CYP2 clan (304 sequences, in 46 bins) no CYP21 found

 

$$$$$$$$$$

 

>estExt_fgenesh2_pm.C_1150001|Brafl1 39% to CYP1A1

MAAVATAALFGLSYLQVVLIAVLLVLVAAVVASSLRQNTPSLPPGPWGFPVVGIFPALGSRPHHAFSRMAEKYGDVFRVK

FGSRTVIILNGIDMVKDAFVKQSACFAGRPALYSFKQVKNGITFKTYSPSWVARKKVTVGALKGFVNGRVGALTASAETM

ITEEAQELARVFLSKSGQPSNPEEYAHTAVANVVCALCFGKRYEHGDQEFRQLLRNTEKFRQAIGAGNPADFMPWLRFFP

NKNMKLFKEAMESSTQLFDKHINAHLQTYDPSVIRDIADALIYNMRENKEAGLTDEFVLECVIDIFGAGQDTTSQMLHWA

FLYMLVFPDVQARVQREIDGVVGRERAPTLADEASLPYTVAVIQEIVRHTGVVPMSIPHLTTKDTQLHGYTLPKDTIVFA

NLFSVGHDRRIWGDPSSFRPERFLDPSGTTLDPAAVEKNLPFSAGKRRCPGEHLAKQEMFLFFSILLQQCSFERVNGTAS

PTLEGTFGLVMRPQPYSMIVRPR*

>estExt_fgenesh2_pm.C_30022|Brafl1

99% to estExt_fgenesh2_pm.C_1150001|Brafl1

MAAVATAALFGLSYLQVVLIAVLLVLVAAVVASSLRQNTPSLPPGPWGFPVVGIFPALGSRPHHAFSRMAEKYGDVFRVK

FGSRTVIILNGIDMVKDAFVKQSACFAGRPALYSFKQVKNGITFKTYSQSWVARKKVTVGALKGFVNGRVGALTASAETM

ITEEAQELARVLLSKSGQPSNPEEYAHTAVANVVCALCFGKRYEHGDQEFRQLLRNTEKFRQAIGAGNPADFMPWLRFFP

NKNMKLFKEAMESSTQLFDKHINAHLQTYDPSVIRDIADALIYNMRENKEAGLTDEFVLECVIDIFGAGQDTTSQMLHWA

FLYMLVFPDVQARVQREIDGVVGRERAPTLADEASLPYTVAVIQEIVRHTGVVPMSIPHLTTKDTQLHGYTLPKDTIVFA

NLFSVGHDRRIWGDPSSFRPERFLDPSGTTLDPAAVEKNLPFSAGKRRCPGEHLAKQEMFLFFSILLQQCSFERVNGSAA

PTLEGTFGLVMRPQPYSMIVRPR*

 

$$$$$$$$

 

>e_gw.391.44.1|Brafl1 35% to CYP1B1 (no allele)

PGPVAFPVIGSLVSLGDTPHETFSAMGRTYGNICSFWLGTRLVVVLNGYETMREAFLDKAGCFSHRPSYFLPKLASGGIS

GGK*

 

$$$$$$$$

 

>e_gw.391.25.1|Brafl1 49% to CYP2U1 (no allele)

QVQDEIDRVVGKDRLPSLIDRSNLPYTEATMMEVSRLRLTGPLSLTHVTQQDTELSGFNIPKGTVIIPNVCSVSTNPEVW

KNPLEFDPAGFLDSDGRLMKEGVFLPFSSGNISF*

 

$$$$$$$$

 

>fgenesh2_pm.scaffold_430000009|Brafl1 35% to CYP2U1 (no allele)

MVAYLSPFTWGLIVAVLVPLSVYFYLNRRRGNFPPSPPGSWPILGHLFALGREPHLQLTEWSKQHGDVFSIRLGMEDVVV

LNGGRTIKDALVEARHAFSSRPDVYVLDAITGFGQSIATARWTDEFVLRRKLSYNILKSLGMRLSPGHAEDVVLEEADCL

CQKIQSYNGEPFDIVEVSNAAFSNVVCSMVFGRRFDYDDSKLSQLRRNVKDIARAISSCQILSLFPILRFLPLENQSGRK

AIRLAEMLQAFIREEVENHRATLDLANPRDFIDYCLLELAKPNPAGGFTEEHLVYFVANLFTAGTEGGSMTLAWGVLYMI

LNPDIQTKVQEELDRVVGSDGGLPSIRHRLQLPYVEATVLEIQRIRQVIPLNLPHATTTAVNFRGYDIPAGTQVLTNLWS

AHMDPEVWTDPERFRPERFLDREGRVISSTESFMPFSAGDRLCLGEKLAKVELFLLFSSLMLRFKFMLPEGEPKPSTKGR

CGFTLTPPPFKLCVLPR*

 

$$$$$$$$

 

>estExt_fgenesh2_pg.C_3910009|Brafl1 36% to CYP2U1 (no allele)

MGTLLMTTSLLLSVQWLLRPRNFPPGPWGLPVLGNLHQIAVDPMKSLTEFGKKYGDVYSIRIGMDNVVILCGWDAFKEAI

VNKADEFRMRPSHLYIYKEYADSKGIGFVNDATTHRLNRKFVLKTLKEFGLGKQTLEEDIAQEARYLCHQIYKHDGKPIG

KMGSMLTRSSAGIILRLVFGKHYEWEDPEFKLFVGNITRGFELMTMYGAIFNVYPWLRYIPYVKSLGQAVMDNMSDFKKL

ILDKIEQHRSSRVPGKPRDLVDAFFDELEDNSGVNDFSHLLPMVADLLTAGMETTATTLHWTALYMALYPDVQRKVQDEL

EAAVGKGKAPTLADVSKLPFTEATIKEIQRICNVAPLAVPRMTTTDVELRGYHIPKGTQVCMNLYTVHMDPKYFSEPEVF

NPNRFLGDDGKVQKMEAFAPFSAGRRVCIGEQMARNELLIFFTTMMTHFTFKLPEGAPTPDLSKGKLGITLSPPDFEVLA

VRRTSGDILESI*

 

$$$$$$$$$

 

>estExt_gwp.C_2520124|Brafl1 40% to CYP2U1

MSYCLAGIGFAGYNDEYKSRRRAMVSILRRFGMGKGFMEGKIHEEVLELKKNFAEQAASGEAFDPSRLLGCSVLNVICSM

ILGARFEQDDPLFHRLVALMDRTVAAMGPSQILNVFPWLRFLPGLGETGSDVFSCAEEIRDFLSGVIREQRSQLNNNNDV

SDDVSFVRSLEAALQDDDQVTMIMQDLFIGGAETTTTTLRWALLYLALHPEVQENVQTELDREVGRERRPSLTDKPRLPY

TEASILEIQRVRTIAPLSIPHAASQDVELRGYHIPAGTQVLVNLWSVHMDPAHWPDPERFDPSRFLDEQGKVVRPDQFLP

FSIGRRQCPGEQLARTELFLFLTTLLQHFTFELPEGAPPSTEGVMGISLSPSPYKICVRPRE*

>gw.83.123.1|Brafl1 40% to CYP2U1

95% to estExt_gwp.C_2520124|Brafl1 (allele)

KKKKPLAGPPGYPLIGNLPSLGANPHLQLTEWRREYGDIYRIRMGLQDAVILNGYDVIREALLKKADRLSDRPYMYVLHE

LSCGGKGIGFAGYNDEYKNRRRAMVSILRRFGMGKGFMEGKIHEEVLELRKNFAEQAASGEAFDPSRLLGCSVLNVICSM

ILGARFEQDDPLFHRLVALMDRTVAAMGPSQILNVFPWLRFLPGLGQTGSDVFRCAEEIRDFLSGVIRKQRSQLNNNDDV

SDDVSFVRSLEAALQEDDQVTMIMQGASDLFIGGAETTTTTLRWALLYLALHPEVQENMQIELDREVGRERRPSLTDKPR

LPYTEASILEIQRVRTIAPLSIPHAASQDVELRGHHIPAGTQVLVNLWSVHMDPAHWPDPERFDPSRFLNEQGKVVRPEQ

FLPFSIGRRQCPGEQLAKTELFLFLTTLLQHFTFELPEGAPPSTEGVMGISLSPSPYKIRVRPR

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_8000022|Brafl1 38% to CYP2U1

MRSDSISVKNRNGIIIIFIIIINFSIGIIIITIITVIIIIIIIIIIIVKCGIPPGLPLLGNLLSLTREPHLQLTAWRRRY

GDVFSLRMGPQDVVVVNGCAAIKEALVMKGAHFSDRPALFLTETSQSQKGIIMKKYGADWKSFRRFGLSSLRYFGVGKKT

LEPSIQQECRRLCQSFEGMDGEPFNPCRFLQIATGNVINAIALGRRFEPNDPDYQEQLERTDVAFKLFLQAQILNFYPTL

RYVPGLRGMLKKWKEVYILSVQWFQKIINDHKTTFDPSEIRDVTDVCLLELKESNTFLKEENTWHIVGDFLAAGTETTAT

TLSWALLYLALNPAWQRKVQEELGIVVGSDEIPPYSRREELPYTEATILESQRIRTTVPLSVPHCTSSPTSLQGYDIPAH

TQVWVNLWSVHMDPAYWSQPDTFDPGRFLDDNGRVQVPESFMPFSTGRRICLGEQLAKMELFLFLTSLLQKFTFKLPEGA

PVPDMSGEIGVTLLPKPYKLQAISRKTSM*

>fgenesh2_pm.scaffold_120000019|Brafl1

83% to fgenesh2_pg.scaffold_8000022|Brafl1

MESIDLTTGLVLVCSFMLSLLCLRTWVGHRGRPDKFPPSPPGLPLLGNLLSLIREPHLQLTAWRRRYGDVFSLRMGPQDV

VVVNGCAAIKEALVMKGAHFSDRPALSGSDFIKESCVSHGCISPGIIMRKDGDDCQSIRRFGLSSLRYFGVGKKTLEPSI

QQECRRLCQSFKQMEGELFDATCFLRMATGNVINAIALGTRFESDDPDYQEQLKRIDIIFKLFLQAQILNFYPTLRYVPG

LRGLTKKWKEVNSLSKQWLQKIIEDHKKTFDPSETRDVIDMCLLEVYQCKGSKALLKEDNIKNTIADFLAAGTETSATTL

SWALLYLALNPAWLRNVQEELDAVVGSDEIPPYSRREELPYTEATILDLESQRIRNTVPLSVPHCTSSPTSLQGYDIPAH

TQVWVNLWSVHMDPAYWSQPDTFDPGRFLDDNGRVQVPESFMPFSTGRRICLGEQLAKMELFLFLTSLLQKFTFKLPEGA

PVPDMSGEIGSTLLPKPYKIQAISRKI*

>fgenesh2_pg.scaffold_120000122|Brafl1 42% to CYP1A1

99% to fgenesh2_pm.scaffold_120000019|Brafl1

MESIDLTTGLVLVCSFLLSLLCLRTWVGHRGRPDKFPPSPPGLPLLGNLLSLIREPHLQLTAWRRRYGDVFSLRMGPQDV

VVVNGCAAIKEALVMKGAHFSDRPALFLTETSQSQKVI*

 

$$$$$$$

 

>fgenesh2_pg.scaffold_4000070|Brafl1 35% to CYP2U1

MAVFKEQSPFKTYTGDFTGFLVVVLAVLVVCVSRGKRRRTGTFPPGPPAWPLLGHLPLLDRRPHVKFSEWSREYGPVLGV

RLGPHRVVVLNDYESAREALVVRADVFSSRPDLYLMRLFSNGGKVCWKAQRRFTDRTLRRLGIGKVTFEGKVMREVDDLV

SKISDCHGAAFDPKYHVGVGVVNIVCSLVFGEHFKHDDPLFLKLFNALEDISRYGGSTKHLNIFPALRHVPVLNRGAVRT

MAAVSNGRDFISAMIGQHKATFDPSNIRDFIDAYLLAISSEEIEEKRDRFLNEEELRQDIFDLFIAGTESTTATILWALL

LLSAHPEIQTKLQDELDSALGPHQDVSVLDRPYLPYTEATILEVLRFRPTPFGLPHATTEDTTLGGFEIPAKTQVLINRW

ALNMDDRKWSHPDKFDPGRFLDPEGHLDVPVYFRPFLMGRRACIGSHLAKMELLLFLATILRRFTIKPPEGAPAQSLEGH

LGVILQPPSFRICAVPRSTTEN*

>fgenesh2_pm.scaffold_271000007|Brafl1

95% to fgenesh2_pg.scaffold_4000070|Brafl1 (allele)

MAVFKEQSPFKTYTGDFTGFLVVVLAVLVVCVSRGKRRRTGTFPPGPPGWPLLGHLPLLGRRPHVKFSEWSREYGPVLGV

RLGPRRVVVLNDYESAREALVVRADVFSSRPDLYLMRLFSNGGKGIGLAPYTAKWKAQRRFTDRTLRRLGIGKVTFEGKV

MREVDDLVSKISDCHGAAFDPKYHVGVGVVNIVCSLVFGEHFKHDDPLFLKLFNALEDISRYGGSTKHLNIFPALRHVPV

LNRGAVRTMAAVSNGRDFISAMIGQHKATFDPSNIRDFIDAYLLAISSEEIEEKRDRFLNEEELRQDIFDLFIAGTESTT

ATILWSLLLLSVHPEIQRKLQDELDSALGPHQDVSVLDRPYLPYTEATILEVLRFRPTPFGLPHATTADVTLGGFEIPAK

TQVLINRWALNMDDRKWSHPDKFDPGRFVDPEGHLDVPVYFRPFLMGRRACIGSHLAKMELLLFLSTILRRFTIKPPEGT

PAQSLEGHLGVILQPPSFRICAVPRSTTEN*

 

$$$$$$$

 

>estExt_fgenesh2_pg.C_2090026|Brafl1 33% to CYP2D6

MIQPKTLTARITERVFMTPEPASLVLFLATFLLMVRYLTGRPIGKLPPCLPNAWPILGHLPSIGLRADLAFTKLGKKYGD

IFQAQLGTWNVVVLNSYQALKEGYIDGGDAYNDRPHFYSYQLFSDGGKGTAFADDSPAFRKKRQFMVKVFHHFGSGKAYQ

QLDTNIAEEARKLVDVSKGLEGKPFDMQPYVTVTTLNIICSMVFGKLHDYHDEGFARVMKNLDNVTMNMINVGVLNVFPF

LRHIPAINSSAREILENKRKIMSFVNDIIEEHRATYDPDHTRDLVDAYLKTQSGDGRSEFLTDEELAHMAVELMVSGNDA

SSYALQWGILFMALHPEIQEKVQREIDDVIDPNTNVSISLRQHLPYTHATTLEILRYRPLAPINGRKTKRPVKLRNYELP

ADTIVLTNVWNILHDPETWSEPETFNPARFLDSEGQVFVPPQFKPFGAGRRICTGQQVAKQMLFTIFTTLMQHFTFKLPE

GAPAPDTEGTVGMMLGPKPFQVCAIPRH*

>estExt_fgenesh2_pg.C_6100007|Brafl1

98% to estExt_fgenesh2_pg.C_2090026|Brafl1 (allele)

MIQPKTLTARITERVFMTPEPASLVLFLATFLLMVRYLTGRSIGKMPPCLPNAWPILGHLPSIGLRADLAFTKLGKKYGD

IFQAQLGTWNVVVLNSYQALKEGYIDGGDAYNDRPHFYSYQLFSDGGKGTAFADDSPAFRKKRQFMVKVFHHFGSGKAYQ

QLDTNIAEEARKLVEVSKGLEGKPFDLQPYVTVTTLNIICSMVFGKLHDYHDEGFARVMKNLDNVTMNMINVGVLNVFPF

LRHIPAINSSAREIVENKRKIMSFVNDIIEEHRATYDPDHTRDLVDAYLKTQSGEGRSEFLTDEELAHMAVELMVSGNDA

SSYALQWGILFMALHPEIQEKVQREIDDVIDPNTNVSISLRQHLPYTHATTLEILRYRPLAPINGRKTKRPVKLRNYELP

ADTIVLTNVWNILHDPETWSEPETFNPARFLDSEGQVFVPPQFKPFGAGRRICTGQQVAKQMLFTIFTTLMQHFTFKLPE

GAPAPDTEGTVGMMLGPKPFQVCAIPRH*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_453000019|Brafl1 34% to CYP2U1

MATSWISPMLASIILSFSPVQILTIVLCTILFGFYAFLGRKKNFPPSPSGSWPVVGHLPLLGREAPYQKLTEWRQEYGDV

YSIRMGMSDVVVLNGHRAIKEALVDKREIFADRPDNFIVDGIATTKWSQSYRERRRFATTALKTLGMKAGSDSVEKSVLE

EVHSLKDRISQSKGQPIHLSGDLGIATANVIASMVFGRRFEYGDSYFRGLTDALLLAYIKIAESQAINVFPALRFVPIVN

RAGWEALDCGRKVDDFIREEIQRHRETASPGGEPRDFIDMCLLEMAKNKAEVTSGAGITEEHMVFMVHDLFFAGIETIHS

TLLWGFLYLAMHRDIQEKVQAELDSVMGKDPSNDVTLAHRAQLPYTEATLMEAQRVRYVVPLSIPHAATAPVTFRGYQLP

AGTSVIANLWSVHMDPEYWPDPERFDPERFLDAEGKVINNPDSFLPFSAGRRVCLGALLAKMELFLLFASLLRHFTFQLP

EGAEEPSTLGCYGITMSPRPFQLCVRSR*

>e_gw.57.165.1|Brafl1

93% to fgenesh2_pg.scaffold_453000019|Brafl1

MATSWISPVVDFIILSLSPVQIFTIVLCTILFGFYALLGRKKNFPPSPSGSWPVVGHLPLLGREAPYQKLTEWRQEYGDV

YSIRMGMSDVIVLNGHRAIKEALVDKREIFADRPDNFIVDGMSGWGQGIATTKWSQSYRERRRFATTALKTLGMKAGSDS

VEKSVLEEVHGLEDRILQSKGQPIHLSGDLGIATANVIASMVFGRRFEYDDSYFRGLTDALLLAYIKIAESQAINVFPAL

RFVPIGEDVGWEALDCGRKVDDFIREEIQRHRETAPPGGEPRDFIDMCLQEIVKNKAEVTSGAGITEEHTVFMVHDLFFA

GIETIHSTLLWGFLYLAMHRDIQEKVQAELDSVMGKDPSNDVTLAHRAQLPYTEAALMEVQRVRYVVPLSIPHATTAPVT

FRGYQLPAGTAVIANLWSVHMDPEYWPDPERFDPERFLDAEGKVINNPDSFLPFSAGRRVCLGGLLAKMELFLLFASLLR

HFTFQLPEGAAEPSTLGCYGITMSPRPFQLCVRSR*

 

$$$$$$$

 

>e_gw.515.2.1|Brafl1 40% to CYP2U1

no allele next best match is 67%

GIVTARWGHGFKQKKKFSISVLKILGMKVGKNSIEDKIQEEAMYCIFLAQIAEYRGKRFDAEEEIRTTIANVLCSMIFGN

RFDYGDEKFRELAEAMVVTLVSIASGQPISIFPFLRFVPYVNKPCNDAIKYNEKILKFIRDEISRHRRDLDCENPRDFLD

FCLIEVDRHDKVDNLTEENVMHVVQELLFGGIDTTTNTLRWGLMYMVLYPDVQKKVQSELDAVVGGTLPTISHRSQLPYT

EATVMEVQRLRSVVPLGLPHATTQQVKLAGFDIPAGTQVLMNLHSVHADPVYWPDPDRFDPGRFLDTEGRVVSKLDSFMP

FSGGRRVCPGEQLGKMELFLLFSSLLQNFTFKLPEGAPPLSTEGILAITLMPHSFKLCAIPR*

>fgenesh2_pg.scaffold_182000031|Brafl1

67% to e_gw.515.2.1|Brafl1

MAAGVLFSEIFQLSCLNLQTFLVFFVAFLLACLYLRRPRNLPPYPAGCWPVLGHLIALGRAPHLKLTAWRRQYGDVFTVR

MGMEDVVVLNGYTAVKDALVDRSELFASRPQNYLFDFVTSFGKGQPFDPEGDLQVTIANVICSTAFGSRFDYGDERFKKL

GEAVLIIVDRLGAGQIINVFPFLRFVPGVNKSLRDVSKYNAKIHAFLWDEISRHRHNLDRENPRDFLDFCLVELEKREKV

EDFTEEQAMCLTYEFFIAGVDTLTNTMQWCLLYMVLYPDVQKKVQSELDAVVGGAQPALSHRAQLPYTEATLMEVQRMRP

VGPLGLPHATTQDVTVGVFDLPAGVKILTNLHSLHMDPAYWPDPDRFDPERFLDTEGKVISKPKSFMPFSGGRRVCLGEQ

LAKMELFLLFSSLLQNFTFKSPEGAPVLSAEGILRITLAPPSYKICAIPR*

>fgenesh2_pm.scaffold_140000004|Brafl1 40% to CYP2AA7

66% to e_gw.515.2.1

MKVGKGSIEEKIQEEGRSLCERFAAYQGRPFDAERDLQVTIANVICAMAFGHRFAYGDERFAEMAEAIVSVQMNLASLSG

QLISVFPFLRFVPGVNKVVNNTILYAEKIDAFLWEEISRHRRDLDRENPRDFLDFALIEVEQQGRVNDLTEENVMYMAQN

LFVAGTDTVSTTLRWALLYMALNPDIQEKVQQELDDVIGDTVPSLSHRAQLPYTEATVMEVQRVRTTVPMGLPHATTQHV

KLGQFDLPAGTQVLTNLYSLHTDPAYWPDPDRFDPDRFLDGEGHVIGKPHSFMPFSGGRRVCLGEQLAKMELILLFCGLM

QNFTFKLPEGALPVSTDGILRISLTPHPHKICAIPR*

 

$$$$$$$

 

>e_gw.774.2.1|Brafl1 42% to CYP2U1

YRVIREALVDCRDVFSSRPDLYLPNAISGCGKDIVIAKWGQPYRERRRFASSVLKTLGMKEGTGSAEDIIRQEARKLCSK

ISAKASQPFDVLGDLNNAVSNVICALVFGQQFGYDDETFRALREGVVQGAARVSTAQAFNVFPFLRFVPGSCKEVLADIR

KVEDFIWVQIEEHRQRLDPDNPQDFLDMCLLEVRGHGRVEGLTEENVMYIVSNLFLAGTETTTTTLRWALLYMILHPHIQ

QRVQEELESVVGKSGDPPTLAQRSRLPYTEAVLMETQRIRHITPLSIPHATAVDTVFRGYHIPAGTQVVPNMWSAHMDPE

FWPDPERFDPRRHLDWEGNLVKNPESFMPFSVGRRMCLGERLAKMELFLFFTAMLQQFSFVLPEGAATPSTDGVFGITMS

PQPYQLCAIDRS*

>e_gw.496.32.1|Brafl1

97% to e_gw.774.2.1|Brafl1 (allele)

LTEWRGGYGDVFSIRMGMERVVVLNGYRVIREALVDCRDVFSSRPDLYLPNAISGCGKDIVIAKWGQPYRERRRFASSVL

KTLGMKEGTGSAEDIIRQEARKLCSKISAKDSQPFDVLSDLNNAVSNVICALVFGQQFGYDDETFRALREGVLQGAARVS

TAQAFNVFPFLRFVPGSCKEVLADIGKVEDFIWEQIEEHRQRLDPDNPQDFLDMCLLEVRGHGRVEGLTEENVMYIVSNL

FLAGTETTTTTLRWALLYMILHPHIQQRVQEELESVVGKSGDPPTLAQRSRLPYTEAVLMETQRIRHITPLSIPHATAVD

TVFRGYRIPAGTQVVPNMWSAHMDPEFWPDPERFDPGRHLDWEGNLVKNPESFMPFSVGRRMCLGERLAKMVLFLFFTAM

LQQFSFVLPEGAATPSTDGVFGITMSPQPYELCAMDRS*

 

$$$$$$$$$$$$

 

>fgenesh2_pg.scaffold_4000065|Brafl1 30% to CYP2U1

MTPDVGLVSLPPADSGALTAALVLVLVSMLVALSRRRPRDFPPAPPGVRAWPLLGHLPALGPEPHRTLAAWTDSCGDVLG

LRFGMSDVVVLNSLEAMREALVAQGDAFSSRPRMFMMDIFSDGGKGLVFRAFGKSLMEQRKFAMVVFRDILSRPRTESMM

IREAQTLASTLAQKAGRPTRVHDNIGLSLLNVTCSLCFGRRFETSDPRVPKINTPAVRVQTGIREVKEFVRSETEGHKVK

FDRENIRDIIDAFVLEMESRRRSGRDLGSFTEREMEQVIFDLFFTGAETSSTCLRWAVFLMAVYPDVQVIFDLFFTGAET

SSTCLRWAVFLMAVYPDVQARIHRELDTVLGPDGEVTLDKRAALPFLDATISEVLRFRPAAPFMYRCATKDSKLRDYFIP

ADTQVLVNLWSIHMDPKHWQNPDQFNPDRFLNSEGTVKIPEAFKAFGLGRRLCFGEQMARMEMFLFFAILMQHFTFKLPE

GAPVPNTIGVFALTLSPPPHELCIFKRH*

>fgenesh2_pg.scaffold_2709000001|Brafl1 57% to CYP2D6

96% to fgenesh2_pg.scaffold_4000065|Brafl1

VKEFVRSETEGHKVKFDRENIRDIIDAFLLEMESRRRSGRDLGSFTEREMEQLSFVQQRGRRLCFGEQMARMEMFLFFAI

LMQHFTFKLPEGAPVPNTMGVFALTLSPPPHELCIFKRQ*

>fgenesh2_pg.scaffold_271000048|Brafl1 31% to CYP2K16

82% to >fgenesh2_pg.scaffold_4000065|Brafl1

MTPDVGLVSLPPADSGALTAALVLVLVSMLVALSRRRPRDFPPAPPGVRAWPLLGHLPALGPEPHRTLAAWTDCCGDVIG

LRFGMSDVVVLNSLEAMREALVAQGDAFSSRPRMFMMDIFSDGGKGLVFRAFFFGKSLMEQRKFAMVVFRDILSRPRTESMM

IREAQTLASTLAQKAGRPTRVHENIGLSLLNVTCSLCFGRRFETSDPRFDFLQDYTLKTLKL KLDKWSKFISAEENRILI

QEFLDKAENINLVISANSAGALSVAPEFPTSLKNKAVYFVKKDKATVTKDGIKTLLSYGDLSYAPLDQLSALVDDLVLQP

TIVCPAHESVVLPPRSHLNFVPIHSAEIVVPLLSNFRNHDAWPTVVSQDVLRHVHNLKNSVYVVAGQVKGKTLLPLPVGT

ERVEQAIDVDEKCTIMMVP*

 

$$$$$$$$$$

 

>fgenesh2_pg.scaffold_62000049|Brafl1 34% to CYP2U1

MATGTLSLEIFEPFRLNIQTFLVFCLVFLLTYLYLRRPRNLPPYPAGWVPVLGHLPALGRAPHLKLTAWRRQYGDVFTVR

MGMEDVVVVNGYKAVKDVIVDRSELFADRAPSYIFDACTGFGKDIGGGRWGNEMKQKRKFISASLKALGMKVGTGSVEEN

IREEAGLLCDKVAKYRGRPFDIERDLHVAIGNVICSMIFGNRFDHADETPSTMQGTDRTCISSLLSNDILLHYSVFSANK

SIKDALHHAAKMQKFIRDEIVRHQQDTDPDNPRDFIDFGLKEVENQGKVKNFTKENVMYIAHDFLLAGIDTSASTLRWAL

LYLAMDTNIQERVQAEIDAVVGGALPALSHRPQLPYTDVCIMEAQRIRTVVPLGLPHATTRQVTINGFDLPAGTQVLNDL

WSVHMDPEYWPDPERFDPSKFLDAEGRIINKPDAFMPFSGGRRGCPGDQLAKMELFLFFTTLLQNFTFRLPEGVTSYPTE

GEFGIVLRPPGSHVLCATPR*

>fgenesh2_pg.scaffold_108000002|Brafl1

97% to fgenesh2_pg.scaffold_62000049|Brafl1

MATGTLSREIFEPFRLNIQTFLVFCLVFLLTYLYLRRPRNLPPYPPGWVPVLGHLPALGRAPHLKLTAWRRQYGDVFTVR

MGMEDVVVVNGYKTVKDVTVDRSELFADRAPPYIFDACTGFGKDIGGGRWGNEMKQKRKFISASLKALGMKVGTGSVEEN

IREEAGLLCDKVAKYRGKPFDIERDLHVAIGNVICSMIFGNRFDHADETFKDLTRSAMTVNSKIGPAQLVSVFPVLRFVP

GGSYHFYVACMPACIPNKSIKDALHHATKLQKFIRDEIVRHQQYSTDPDNPRDFIDFGLKEVENQGKVKNFTKENVMYIA

HDFLLAGIDTSASTLRWALLYLAMDTNIQERVQAEIDAVVGGALPALSHRPQLPYTDACIMEAQRIRTVVPLGLPHATTR

QVTINGFDLPAGTQVLSNLWSVHMDPEYWPDPERFDPSKFLDAEGRIINKPDAFMPFSGGRRGCPGDQLAKMELFLFFTT

LLQNFTFRLPEGVTSYPTEGEFGIVLRPPGSHVLCATPR*

 

$$$$$$$$$$

 

>fgenesh2_pg.scaffold_730000007|Brafl1 39% to CYP2U1

MNVVKVVAGVLDISTVLVLLVSFLATAVLLGRLKRPRLPPGPRAWPVIGNLPSLTKQPHLKFTEWRQQYGDVYTVRMGSD

DVVIVNGWEAVREALVKQADEFADRPRLFVFDRIGHGGKGVIFGHYNSAWKANRKFLTTTLRDFGLGKKSMELRIQEEAN

ELCNWLASYNGRPIETGNLLSNAASNIICSVVFGSRFAYDDQDFRRMLDLLERGTRLSMVGQIFNFFPWARFVPFLSRLG

NEVMDNCDKIDDFLKKIVQKHQDSFDPEVKRDVIDAYLHQMWRGMDLNSNDLAGNFSEECLVALIFDLFIAGTDTSMNTQ

RWALLYLATHPDIQREVQEEVDRVVGRDAPVSLAHRPEMPYTDAFLHEVLRIRPPGPLSVPHMAGPGATLNGYEIPQNTQ

VYANLWSLHMDPEYWPEPERFDPARFIGPDGKVLTNPPSYAPFSLGRRACPGKQLAKSEAFLFLVTMVQRFSFKLPEGAP

VPPMDGVMGFSLAAQPHSLCAISRN*

>estExt_fgenesh2_pg.C_5500013|Brafl1

98% to fgenesh2_pg.scaffold_730000007|Brafl1

MFLAFAMNVVKAVAGVLDISTVLVLLVSFLATAVLLGRWKRPRLPPGPRAWPVIGNLPSLTKQPHLKFTEWRQQYGDVYT

VRMGSDDVIIVNGWEAVREALVKQADEFADRPRLFVFDRIGHGGKGVIFGHYNSAWKANRKFLTTTLRDFGLGKKSMELR

IQEEANELCNWLASYNGRPIETGNLLSNAASNIICSVVFGSRFAYDDQDFRRMLDLLERGTRLSMVGQIFNFFPWVRFVP

FLSRLGNEVIDNCDKIDDFLKKIVQKHKDTFDPEVKRDVIDAYLHQMWRGMDLNSNDLAGNFSEECLVALIFDLFIAGTD

TSMNTQRWALLYLATHPDIQREVQEEVDRVVGRDAPVSLAHRPEMPYTDAFLHEVLRIRPPGPLSVPHMAGPGATLNGYE

IPQNTQVYANLWSLHMDPEYWPEPERFDPARFIGPDRKVLPNPPSYAPFSLGRRACPGKQLAKSEAFLFLVTMVQRFSFK

LPEGAPVPPMDGVMGFSLAAQPHSLCAISRD*

 

$$$$$$$

 

>e_gw.33.119.1|Brafl1 41% to CYP2U1

PHLMWTQLAETYGPVLYLQLGSQRIVVLSSYSAIHEALVKKGEDFSCRPHWYTFQKMGFMDYGIIMLPYGPFWKQQRKYT

IMGLRDFGFGKRSLEGKILEESQGLQEEILKKGENPFNIRLMLQNAVGNVICSIVLGKRFEYNDEKFEKITKAFDQNLGA

EQQLSAVANFFPWARHIPAIKSAVTKVTENVENCVATMREDIAAHKETFDPNDIRDFIDTYLLEIRNKEGQDGNDFSDRQ

LEYLIGDLFLAGTETTSSTLTWALLYMLRHPDIQDKVHQEIDNTIGQNVTPSLTHRSQLPYTEAVIAEVMRINPIAAVGA

MHSTSNDTTLFGYDIPKDTVVFPNIWAVLHNPAVYPEPDVFKPERFLDDSGQFKKGDNFIPFSLGRRACLGEQLARMELF

LFFTSLMQRFAFKLPEGADQPSTIGKPGITNVAEDFDLHAIPRE*

>estExt_gwp.C_490141|Brafl1

99% to e_gw.33.119.1|Brafl1  2 aa diffs

MVVSALFSYLNLQTCVILGVVFLLAYWYLRTRAPTNLPPGPWAWPGLGNVLQMFTKVPHLTWTQLAETYGPVLYLQLGSQ

RIVVLSSYSAIHEALVKKGEDFSCRPHWYTFQKMGFMDYGIIMLPYGPFWKQQRKYTIMGLRDFGFGKRSLEGKILEESQ

GLQEEILKKGESPFNIRLMLQNAVGNVICSIVLGKRFEYNDEKFEKITKAFDQNLGAEQQLSAVANFFPWARHIPAIKSA

VTKVTENVENCVATMREDIAAHKETFDPNDIRDFIDTYLLEIRNKEGQDGNDFSDRQLEYLIGDLFLAGTETTSSTLTWA

LLYMLRHPDIQDKVHQEIDNTIGQNVTPSLTHRSQLPYTEAVIAEVMRINPIAAVGAMHSTSNDTTLFGYDIPKDTVVFP

NIWAVLHNPAVYPEPDVFKPERFLDDSGQFKKGDNFIPFSLGRRACLGEQLARMELFLFFTSLMQRFAFKLPEGADQPST

IGKPGITNVAEDFDLHAIPRE*

>fgenesh2_pg.scaffold_180000055|Brafl1

77% to e_gw.33.119.1|Brafl1  2 aa diffs

MGTAFAGERGPNFHQGQKYGPVLHLQLGSRHVVVLNSYSAIHEALVKKAEDFSDRPVFYSFKQTGFLDNGIILLPYGPFW

KHQRKFTIMGLRDFGFGKRSLEGKIVEESHGLREEILKKGQKPFNIRLMLQNAVGNVICSIVLGKRFEYDDEKFEKIMEA

FDQNVGDQRLSGMADLFPWARHIPAIKRAVAKQVAYAEISVGAVREEIEEHKKTFDANDIRDFIDTFILEMKNKEGDDDS

DFTDRQLEYLIADLFLAGTETTSSTLYWGLLYLLRHPDIQEKVHQEIDGTIGQDVTPSLTHRDQLPYTQAVITEVMRSNP

IAPVGVPHSASNATTLFGYDIPKDCLVFPNLWAALRDPEFYPEPDAFKPERFLDDKGQFNKGDTFIPFSLGRRACLGEQL

ARMELFLFFTSLMQHFTFKLPEGAPLPSTRGKVGLANTAEDFDLYAIPRE*

>estExt_fgenesh2_pg.C_1800074|Brafl1

75% to e_gw.33.119.1|Brafl1  2 aa diffs

MSVWTLSAYLNLQTCLMLGLVFLLAYWYLTRTRGKLNLPPGPWALPLLGNVAQIFTKAPYKLWMELVKEYGPVIYLWLGS

QQIVVLNSYAAIHEALVKKGEDFSNRPALHTFKLMGLTNNGIILLPYGPFWKHQRKFTIMGLRDFGFGKRSLEGKVLEES

HGLREEILKKGQKPFNIRRMLQNAVGNVICSIVLGKRFEYDDEKFEKIMEAFDQNVGDQRLSGMADLFPWARHIPAVKRA

VAKQVSNVEISVGAVREDIAEHKKTFDPNDIRDFIDTFILEMKNKEGDNDSDFTDRQLEYLIADLFLAGTETTSSTLHWA

LLYMLRHPDVQDKVHREIDSTIGQDVTPSLTHRDYLPYTQAVVAEACLVFTNLWAVLRDPEFYPDPDAFKPERFLDNKGQ

FNKGDTFIPFSLGRRACLGEQLARMELFLFFTSLMQHFTFKLPEGAALPSTRGKVGLANTAEDFDLYAIPRE*

 

$$$$$$$$

 

>e_gw.37.226.1|Brafl1 42% to CYP2U1

MLLITTNVIWNISGVVQEPYGTTWKEHRKFTLMSLRDFGVGKRSLEGKILEETRALSDEILKKENQGFCISNMMQVTVSN

VICSIVFGSRYEYDDPKFIRLIEAIDHFFSIPRSGSALLPSLIPILRYIPAVNRNFLKVRAYIGTHILEQIQEHEATFDP

NDIRDLIDAFLLEKRRRQEDENTTFTEQQNILVVMDLFLAGTETTSTTLRWALLYMILHPDMQEKVQQEIDSVIGQSQDP

SMAHRTQMPYTEATLTEVSRLASIAPLSVPHAASNDVTFRGYHIPKGTVVQANLWAVHHDPQLWPDPHRFDPARFLDDAG

KFVKRDEVIPFSIGRRVCLGEQLARMELFLFFTSLLQRFSFKLPEGAPVPSEEGVFGATHSPVPFKLVAVARD*

>fgenesh2_pm.scaffold_442000002|Brafl1

94% to e_gw.37.226.1|Brafl1

MRRPPNFPPGPRGWPLFGVSKAGQLAVTEWIPKYGDIIGYYRGPVRVVSLGSYDVIREAFVKNAEHFSSRPRPLNPTLAT

YKTKGVVQEPYGTTWKEHRKFTLMSLRDFGVGKRSLEGKILEEVRALSDEILKKENKGFCISNMMQVTVSNVICSIVFGS

RYEYDDPKFIRLIEAIDHFFSIPRSGSALLPSLIPILRYIPAVNQKFLKLREVEAYIGTHILEQIQDHEATFDPNDIRDL

IDAFLLEKRRRQGDENTTFTEQQNILVVMDLFLAGTETTSTTLRWALLYMILHPDMQEKVQQEIDSVIGQNQDPSMAHRT

QMPYTEATLTEVSRLASIAPLSVPHATSNDVTFRGYNIPKDTVVQANLWAVHHDPQLWPDPHRFDPARFLDDAGKFVKRD

EVIPFSIGRRVCLGEQLARMELFLFFTSLLQRFSFKLPDGAPVPSEEGVFGATHSPVPFKLVAVARN*

 

$$$$$$

 

>fgenesh2_pg.scaffold_567000020|Brafl1

MFEPLLTGHNITALLVGVLTFLIFVTCRVRKPAGYPPGPPGWPVLGNLPSLAQNAHLQLTAWRGTYGDIFSVKMGLQDAV

VVSGKDAIREALVRKAEHFSSRPDLFLMRRNNHRNGLVMRPYGDQWKVLRRFSMSTLRSCGMGTGIMEDKITLECQHFCT

ALKEKADQPFDLTHLLHNAVANIICSMAIGKRFEYGDPTFLRLMEMVERAMVLFVTAHVINIYPVLRFFPVVGRPYKEWM

DLSASVHKCIEDIIAQQEKSQDVSDEANTIIDAFTKSVELNSDSLPDQSLIYLLIDLLGAGTDTAGNTLRWGLLYLVANS

DVQTKVQAELDEVVGRDRPPAVSDKPNLPYTEATIMEMQRIRTVVPLSVPHCTTSDTALLGYDIPAGTDVLINLWSLHMD

PGSWDNPDKFDPSRFLDGNGQLQTNDSFMPFSTGRRVCLGEQLAKMELFLFLTNMLQQFTFTLPEGARPNFDGVLGVTLR

PHPYELLAVKRG*

>fgenesh2_pg.scaffold_18000177|Brafl1

80% to fgenesh2_pg.scaffold_567000020|Brafl1

VRKPAGYPPGPPGWPVLGNLPSLAQNAHLQLTAWRGTYGDVFSVKMGLQDAVVVSGKDAIREALVRKAEHFSSRPELFLM

RRNNHRNGLVMRPYGDQWKVLRRFSTSTLRSCGMGTGIMEDKIILECQHFCTALKEKADQPFDLTHLLHNAVANIICSMA

IGKRFEYGDPTFLRLMEMVERAMVLFITAHVINIYPVLRFFPVVGRPYKEWMDLSASVHKCIEDIIPQQQKSQDVSDEAN

TIVDAFAKSVELNSDSLPDQSLIYLLIDLLGAGTDTAGNTLRWGLLYLVTHPDVQTKVQAELDEVVGRDRPPAVSDKPNL

PYTEATIMEMQRIRTVVPLSVPHCTTSDTALLGYDIPAGTDVLINLWSLHMDPGSWDNPDKFDPSRFLDGNGQLQTNDSF

MPFSTGRRVCLGEQLAKMELFLFLTNMLQQFTFTLPEGARPNFDGVLGVTLRPHPYELLAVKRG*

>fgenesh2_pm.scaffold_567000008|Brafl1 40% to CYP2U1

98% to fgenesh2_pg.scaffold_18000177|Brafl1

MGTGIMEDKITLECQHFCTALKEKADQPFDLTHLLHNAVANIICSMAIGKRFEYGDPTFLRLMEMVERAMVLFITAHVIN

IYPVLRFFPVVGRPYKEWMDLSASVHKCIENIITQQEKSQDVSDEANTIIDAFTKSVELNSDSLPDQSLIYLLIDLLGAG

TDTAGNTLRWGLLYLVTHPDVQTKVQAELDEVVGRDRPPAVSDKPNLPYTEATIMEMQRIRTVVPLSVPHCTTSDTALLG

YDIPAGTDVLINLWSLHMDPGSWDNPDKFDPSRFLDGNGQLQTNDSFMPFSTGRRVCLGEQLAKMELFLFLTNMLQQFTF

TLPEGARPNFDGVLGVTLRPHPYELLAVKRG*

>fgenesh2_pg.scaffold_18000201|Brafl1

87% to fgenesh2_pg.scaffold_567000020|Brafl1

MFESLVTGHNTTAVLVGVVTFLVFVKLVFRFRVRKPAGYPPGPPGWPVLGNLPSLAQNAHLQLTAWRGTYGDVFSVKMGL

QDAVVVSGKDAIREALVRKAEHFSSRPDLFLMHCNNQRNGIIMRQYGPQWKVLRRFSTSTLRSCGMGTGIMEDKITLECQ

HFCTALKENADRPFDLTHLLHNAVANIICSMAIGKRFESGDPTFLRLMAIVERAMVLFITAHVINIYPVLRFFPVVGRPY

EEWMDLTVKCHDCMTDVIAQQQKSQKASGEPNNIIDAFTKSVELNPDSLPDQSLMYLLIDLFAAGTETTANTLRWGLLYL

MTHPDVQTKVQAELDEVVGRDRPPAVSDKPNLPYTEATIMEMQRIRTVAPLSVPHCTTSDTALLGYDIPAGTDVLINLWS

LHMDPGSWDNPDKFDPSRFLDGNGQLQTNDSFMPFSTGRRVCLGEQLAKMELFLFLTNMLQQFTFTLPEGARPNFDGILG

ATLRPESFKLIAVRRV*

>fgenesh2_pg.scaffold_18000214|Brafl1 39% to CYP1A1

99% to fgenesh2_pg.scaffold_18000201|Brafl1

MFESLVTGHNTTAVLVGAVTFLVFVKLVFRFRVRKPAGYPPGPPGWPVLGNLPSLAQNAHLQLTAWRGTYGDVFSVKMGL

QDAVVVSGKDAIREALVRKAEHFSSRPDLFLMHCNNQRN

>fgenesh2_pg.scaffold_1619000001|Brafl1

98% to fgenesh2_pg.scaffold_567000020|Brafl1

MFEPLLIGHNITAVLVGVITFLIFVTCRVRKPAGYPPGPPGWPVLGNLPSLAQNAHLQLTAWRGTYGDVFSVKMGLQDAV

VVSGKDAIREALVRKAEHFSSRPDLFLMRRNNHRNGLVMRPYGDQWKVLRRFSMSTLRSCGMGTGIMEDKITLECQHFCT

ALKEKADQPFDLTHLLHNAVANIICSMAIGKRFEYGDPTFLRLMEMVERAMVLFVTAHVINIYPVLRFFPVVGRPYKEWM

DLSASVHKCIEDIIAQQEKSQDVSDEANTIIDAFTKSVELNSDSLPDQSLIYLLIDLLGAGTDTAGNTLRWGLLYLVANS

DVQTKVQAELDEVVGRDRPPAVSDKPNLPYTEATIMEMQRIRTVVPLSVPHCTTSDTALLGYDIPAGTDVLINLWSLHMD

PGSWDNPDKFDPSRFLDGNGQLQTNDSFMPFSTGKANNFVVVFS*

>fgenesh2_pm.scaffold_18000023|Brafl1

88% to fgenesh2_pg.scaffold_567000020|Brafl1

MRQYGPQWKILRRFSTSTLRSCGMGTGIMEDKITLECQYFCTALKEKADQPFDLTHLLHNAVANIICSMAIGKRFESGDR

TFLRLMEIVERAMVLFITAHVINIYPVLRFFPVVGRPYKEWMELTVKCHDCMTDVIAQQQKSQKASGEPNNIIDAFTKSV

ELNPDSLPDQSLMYLLIDLFAAGTETTANTLRWGLLYLVTHPDVQTKVQAELDEVVGRDRPPAVSDKPNLPYTEATIMEM

QRIRTVAPLSVPHCTTSDTALLGYDIPAGTDVLINLWSLHMDPGSWDNPDKFDPSRFLDGNGQLQTNDSFMPFSTGRRVC

LGEQLAKMELFLFLTNMLQQFTFTLPEGARPNFDGILGATLRPESFKRIAVRRA*

>estExt_fgenesh2_pg.C_180177|Brafl1 39% to CYP2U1

80% to fgenesh2_pg.scaffold_567000020|Brafl1

MAFLVSIAQAVLTGHNITAVLIAVVAFLTSITLFSWFKTTVRRGRGNLPPGPPGWPVLGNLPSLAQNAHLQLTAWRGTYG

DVFSVKMGLQDAVVVSGKDAIREALVRKAEHFSSRPDLFLLRRNQQHNGLVMSPYGDQWKVLRRFSMSTLRSFGMGTGTM

EEKIDMECRHFCTELETMSGQPFDLMHLLHNAVSNIMCSMALGKRFEYGDPMFLRLMEISERGVELFLTAHVFNIYPVLR

FFPIVGRQYQEWMDLSEESLKYFMDFIAQHEQSDGQEKARDVIEAFRAKLEEDPGSLPSHSLPHLLGDLFVAGMETTANT

LRWGLLYLVTHPDVQTKVQAELDEVVGRDRPPAVSDKPNLPYTEATIMEMQRIRTVVPLSVPHCTTSDTALLGYDIPAGT

DVLINLWSLHMDPGSWDNPDKFDPSRFLDGNGQLQTNDSFMPFSTGRRVCLGEQLAKMELFLFLTNMLQQFTFTLPEGAR

PNFDGVLGVTLRPHPYELLAVKRG*

 

$$$$$$$$

 

>estExt_fgenesh2_pg.C_550002|Brafl1 38% to CYP2U1

MYLLHGLLQSPWDLYGCLKLAMIVFCLWWLRKRRNLPPGPFNWPILGNFLSLTQDEPMLLMTWARQYGDVFMYHVGSRAV

VVLNGYRTIHQALVKQADDFSSRPYMPITAENSQKKGVIHVPYGPFWKQHRKLTLLKMREIGVDKPILDQKIAEEGKSLI

QEILKKEGQPFDMTKLIQTAVSNIISTMLCGRRYAYDHPGFQRFISNVALNFKFSRLSMLPNHYPWTKWVPGLNTTFNRT

LECNQEIREHIRETLVDHEKLFDPDNIRDFMDAFLNEIRHQDDEDTTASKEQLVQVIRDMFVAGIENIATALRWALLYSA

LYPDIQEKVQEEIDQVLGRDGTPTMAERKKMPYTEATIEEVLRYATVAPLTVDHATSRDTSLNGYFIPKDTLVQVNLWSV

HHDPETWPDPEMFDPTRFLNDQGQFQKKAENIPFSLGRRICLGERLARAELLLFFMLLLQHFHFKLPEGVARPSEKGIFG

ITYNPVDFDIVAVPRFSDM*

>estExt_fgenesh2_pm.C_3850001|Brafl1

95% to estExt_fgenesh2_pg.C_550002|Brafl1 probable allele

MYLVHGLLQSPWDLYGCLKLAVIVFCLWWLRKPRNLPPGPFNWPILGNFLSLSQDEPMLLMTWARQYGDVFMYHVGSRAV

VVLNGYRTIHQALVKQADHFSSRPYMPITAENSQKKGVIHVPYGPFWKQHRKLTLLKMREIGVDKPILDQKIAEEGKSLI

QEILKKEGRSFDMTKLIQTAVSNIISTMLCGTRYEYDHPGFQRFISNVALNFKFSRLSMLPNHYPWTRWVPGLNTTFNRT

LECNQEIREHIRETLVEHENSFDPDNMRDFMDAFLNEIRHQDDEDTTASKEQLVQVIRDMFVAGIENIATALRWALLYCV

LYPDIQEKVQEEIDQVLGRDGTPTMAERKKMPFTEATIEEVLRYATVAPLTVDHATSRDTSLNGYFIPKDTLVQVNLWSV

HHDPETWPDPETFDPTRFLNDQGQFQKKAENIPFSLGRRICLGERLARAELLLFFMLLLQHFHFKLPEGVARPSEKGVFG

ITYNPVDFDIVVAVPRFRDM*

 

$$$$$$$

 

>estExt_fgenesh2_pg.C_1960095|Brafl1 33% to CYP2U1

MVQCSMVEEGANFLLLCAIFAMSIYLLWQHFNPPGLPPGPAGFPGIGVLPSLGPTPYKTLMELSKTYGDVMSLRLGPSLV

VVLTGRRAMTEALVKKADVFSDRPPMGLLNLVHKGRGLMVAKYGPKVHGFRTLLLGTFRRLGVSTPRVDGLLRPELAALV

AAMDQQAGQPTDPKALLSVSASNMICTLAFGKRFDYDDVNFQKFLGKLHNIFEISSSPLGFLILHIPAIVNLPISAIKDT

ISDCNFMLYFLRAIVDERWLALEARRRNDPNIAEWEEPSDLLDGYLRKIGGEDAVGMSVSKEDIAHHFLDLFTAGTESVS

HFLQWELLYLTTHPEVQAKAREELDRVVGRARLPSVSDRANLPYMRALIDEVHRMSSFSPLGIPRMTAHIVDIDGYIIPK

ETMVLTSVWDLHKDPDKWQNPDSFDPSRFLLSNGQVNESKLRQLQAFGLGYRSCVGRQFAESSVFLYTAFLLQRFFFKSP

EGVPPPSLAEDPGVFLTPKPFKVCAIRRNSE*

>fgenesh2_pg.scaffold_236000065|Brafl1 37% to CYP1A1

100% to estExt_fgenesh2_pg.C_1960095|Brafl1

MVQCSMVEEGANFLLLCAIFAMSIYLLWQHFNPPGLPPGPAGFPGIGVLPSLGPTPYKTLMELSKTYGDVMSLRLGPSLV

VVLTGRRAMTEALVKKADVFSDRPPMGLLNLVHKGR

>estExt_fgenesh2_pm.C_2360008|Brafl1 35% to CYP2U1

97% to estExt_fgenesh2_pg.C_1960095|Brafl1

MDQQAGQPTDPKALLSVSASNMICTLAFGKRFDYDDVNFQKFLGKLHNIFEISSSPLGFLILHIPAIVNLPISAIKDTIS

DCNFMLDFLRAIVDERWLALEARRRSEPNISEWEEPSDLLDGYLRKIGGEDAVGMSVSKEDIAHHFLDLFTAGTESVSHF

LQWELLYLTTHPEVQAKVREELDRVVGRARLPSVSDRANLPYMRALIDEVHRMSSFSPLGIPRMTAHIVDIDGYIIPKET

MVLTSVWDLHKDPDKWQNPDSFDPSRFLLSNGQVNESKLRQLQAFGLGHRSCVGRQFAESSVFLYTAFLLQRFFFKSPEG

APPPSLAEDPGVFLTPKPFKVCAVRCNSE*

 

$$$$$$$$$$$

 

>fgenesh2_pm.scaffold_226000008|Brafl1 39% to CYP2U1

MGGGLSFFNNNNNNNGLFKSGRQKNLPPGPRGLPLLGNLLSFRPSRLLSNLAAWRQQYGDVFCVRIANRLAVVLNGHKAI

QDALVKQPEVFSNRPPAVVDSANDQGVVMAQYGEGWKVKRRLGLTALRQFGMGKRSLEGKITEEARAVCDILAEKDGAAT

DISLLLSNGVSNVICSMSFGERFEYNDTEFQRLMRLMSELVGGSAISRFNPYVRKLPFIRKGVESRVKMSMEIVEFIKLK

IKEHKETFDPADIRDIIDVYLMETQQQTPDDGDRTITEMGMINTMRDLFIAGAETTATTLKWGLLYLARHLEVQRKVQDE

IDREFGSSPPTLSQRGKLPYTEATILEIQRIRPIVPLSVPHTTSTATVLHGFDIPANTFVIPNLWSAMMDPTVAPDPETF

NPDRFLDEDGTLVRPEWFIPFSLGRRQCLGEQLAKMELFIFLTTLLQHFTFKLPDGAPAPSMDGSLGVVLAPNPYQICAV

PRDN*

>fgenesh2_pg.scaffold_29000116|Brafl1 37% to CYP2U1 35% to CYP2R1

96% to fgenesh2_pm.scaffold_226000008|Brafl1

MESAVPFVSGLLANLTLQSTLVLVLAFLTTYWLLGAGGRQKNLPPGPRGLPLLGNLLSFRPSRLLSNLAAWRQQYGDVFC

VRIANRLAVVLNGHKAIQDALVKQPEVFSNRPPAVVDSANDQGVVMAQYGEGWKVKRRLGLTALRQFGMGKRSLEGKITE

EARAVCDILAEKDGAATDISLLLSNGVSNVICSMSFGERFEYNDTEFQRLMRLMSELVTGSAISRFNPYVRKLPFIKKGV

ESRMKMAKEITEFIKAKIKEHKDTFDPADIRDIIDVYLMETQQQIPDDGDRTITEMGMINTMRDLFIAGAETTATTLKWG

LLYLARHLEVQRKVQDEIDQEFGSSPPTLSQRGKLPYTEATILEIQRIRPIVPLSVPHTTSAATVLHGFDIPANTFVIPN

LWSAMMDPTVAPDPETFNPDRFLDEDGTHVRPEWFIPFSLGRRQCLGEQLAKMELFIFLTTLLQHFTFKLPDGAPAPSMD

GSLGVVLAPDPYQICAIQRDN*

>e_gw.29.152.1|Brafl1

92% to fgenesh2_pm.scaffold_226000008|Brafl1

MESAVAFASGLLANLTLQSTLVLVLAFLTTYWLLGAGGRQKNLPPGPRGLPLLGNLLSFRPSRLLSNLAAWRQQYGDVFC

VRIANRLTVVLNGHKAIQDALVKQPEVFSDRPSPFRFSDKDQGVVMAQYGESWKVKRRLGLTALRQFGMGKRSLEGKITE

EARAVCDILAEKDGTATDISLLLSNGVSNVICSMSFGERFEYNDAEFQRLMRLMSELVSAGGISRFIPLVRKLPFFNEGS

KNRAKMSMEIVEFIKAKIKEHKETFDPADIRDIIDVYLMETQQQTPDDVDRTITEMGMIGTVRDLFIAGAETTATTLKWG

LLYLARHLEVQRKVQDEIDREFGSSPPTLSQRGKLPYTEATILEIQRIRPIVPLSVPHTTSAATVLHDFDIPANTFVIPN

LWSAMMDPTVAPDPETFNPDRFLDEDGTLVRPEWFIPFSLGRRQCLGEQLAKMELFTFLTTLLQHFTFKLPDGAPAPSMD

GSLGVVLAPKPYQICAVPRDN*

>fgenesh2_pg.scaffold_226000036|Brafl1

92% to fgenesh2_pm.scaffold_226000008|Brafl1

MESVVPFASGLLANLTLQSTLVLVLAFLTTYWLLGAGGRQKKPPPGPRGLPLLGNLLSFRPSRLLSNLAAWRQQYGDVFC

VRIANRLAVVLNGHKAIQDALVKQPEVFSDRPSPFRFSDKDQGVVMAQYGESWKVKRRLGLTALRQFGMGKRSLEGKITE

EARAVCDILAEKDGAAMDVSLLLSNGVSNVICSMSFGERFEYNDEEFQRLMRLMSELVSAGGISRFIPLVRKLPFLNEGS

KNRAKMSMEIVEFIKVKIKEHKETFDPADIRDIIDVYLMETQQQTPDDVDRTITEMGMIGTVRDLFIAGAETTATTLKWG

LLYLARHLEVQRKVQDEIDREFGSSPPTLSQRGKLPYTEATILEIQRIRPIVPLSVPHTTSAATVLHGFDIPANTFVIPN

LWSAMMDSAVAPDPETFNPDRFLDEDGTLVRPEWFIPFSLGRRQCLGEQLAKMELFIFLTTLLQHFTFKLPEGAPAPSMD

GSLGVVLAPKPYQICGVPRDN*

>estExt_gwp.C_300162|Brafl1

88% to fgenesh2_pm.scaffold_226000008|Brafl1

MESAVSFVSGLLANLTLQSILVLVLAFLVTYWLLGTGDRQKNLPPGPRGLPLLGNLLSFRPSYLLSNLAAWRDKYGDVFC

VRIANRLAVVLNGHKAIQDALVKQPEVFSNRPPPFIDSAKDQGVAMSEYGEDWKVKRRIGLTALRQFGMGKRSLEGKITE

EARILCDVLAEKNGTATDMSLLLSNAVSNVICAMSFGERFEHNDMEFQRLMRLMSEMVGGSGGNAGSSISRFIPLVRKLP

FFKKGLERRVKMSLEVVDFIKSKIKEHKETFDPADIRDIIDVYLMETQQQTPDDADRTITEMGMINTMRDLFIAGAETTA

TTLKWGLLYLARHLEVQRKVQDEIDREFGASPPTLSQRGKLPYTEATILEIQRIRPIAPLAVPHTTSTATVLHGFDIPAD

TFVIPNLWSAMMDPAVAPDPETFNPDRFLDEDGTVVRPEWLIPFSLGRRQCLGEQLAKMELFLFLATLLQHFTFKLPYGA

PAPSMEGSMGIVLAPKAYQICAVPRDN*

>estExt_fgenesh2_pg.C_6280014|Brafl1

85% to fgenesh2_pm.scaffold_226000008|Brafl1

MESAVSFVSGLLANLTLQSTLVLVLAFLVTYWLLGAGDRQKNLPPGPRGLPLLGNLLSFRPSHLLSNLAAWRQQYGDVFC

VRIANRLAVVLNGHKAIQDALVKQPEVFSNRPPPMLDSAKDQGVAMSEYGEDWKAKRRIGLTALRQFGMGKRSLEGKITE

EARILCDVLAEKNGTATDMSLLLSNAVSNVICAMSFGERFEHNDMEFQRLMRLMSEMVGGSGGNAGSSISRFIPLVRKLP

FFKKGLERRVKMSLEVVDFIKSKIKEHKETFDPADIRDIIDWGLLYLARHLEVQRKVQDEIDREFGASPPTLSQRGKLPY

TEATILEIQRIRPIAPLAVPHTTSTATVLHGFDIPADTFVIPNLWSAMMDPAVAPDPETFNPDRFLDEDGTVVRPEWLIP

FSLGRRQCLGEQLAKMELFLFLTTLLQHFTFKLPDGAPALSMEGSLGIVLAPKAYQICAVPRDN*

>fgenesh2_pm.scaffold_5000010|Brafl1

61% to fgenesh2_pm.scaffold_226000008|Brafl1

MDLQTLLFLLLFVMVIVLVVRQRRRRLNLPPGPRGFPIVGNLFSMRPSKLLANMAAWRQQYGDVYSLRLLNRVVVVLYGH

KPIHDALVKQADIFSDRPPMRILRRDPGLVMARYGEHWAERRRFALSALRQFGMGRRSAEGRIREEAAALCTAIRSLNGA

QRDISHLLGNAVSNIICSMSFGNRFEYDDAEFKRLSHAFAYLVGSNNRSILALVRQFIMPYLRKLPMMGNWRSYGVKMND

YVIDFIMKSAKEHKETFDKSDIRDIIDVFLSEGDGSEKGNGVNEEALGTIIRDLFIAGSETTATTLRWGLLFTALNPDVQ

TKVQEEIDREFASHAPPWSERGRLPYTEATIMEIQRIRPIVPLNIFHGNTSATTLYGYDIPAGTYIIPSLWSAMMDPKVT

PEPEEFRPERFLDDEGKVVKPEWFLPFSAGRRRCLGEQLAKMELFLFYTSLLQHFTFKLPDGAPAPPMDGSLGFVLSPPA

YDICAVPRHSS*

>e_gw.5.303.1|Brafl1

58% to fgenesh2_pm.scaffold_226000008|Brafl1

MVGVGLFSFVTMDLQTLLFLLLLVMVIVLVVRQRRRRLNLPPGPRGFPIVGNLFSMRPSKLLANMAAWRQQYGDVYSLRL

LNRIVVVLYGHKPIHDALVKQADIFSDRPPIRILRRLVMARYGEHWAERRRFALSALRQFGMGRRSAEGRIREEAAALCT

AIRSLDGAQRDISHLLGNAVSNIICSMSFGNRFEYDDAEFKRLSHAFAYLVGSNNRSILALVRQFIMPYLRKLPMMGNWR

SYGIKQNDYVIDFIMKSAKEHKETFDKSDIRDIIDVFLSEGDGSEKGNGVNEEALGTIIRDLFIAGSETTATTLRWGLLY

TALNPDVQTKVQEEIDREFASHAPPWSERGRLPYTEATIMEIQRIRPIVPLNIFHGNTSATTLYGYDIPAGTYIIPSLWS

AMMDPKVTPEPEEFRPERFLDDEGKVVKPEWFLP

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_776000008|Brafl1 39% to CYP2U1

MSIFKLIATVIHDYTNFTTVLLAVFVFLLTNKLFRRPSNLPPGPRPWPLVGNLYVLSRDAAHIQLTEWTKQYGNVFTIYY

GPKPVVVLNGYDTIQEALINKGEDFSDRQRTNKSLGVAFAPYGPIWREQRKLTMMGLRDFGFGKRSLEGRILEEAAALRN

EIIKTDGKPFNIFPMLRKAVTNVICSIVFGARHEYEDDAFKTFLEDINFRFRNSTANRFPWYLRYVPILGRSSQILHEAT

ERMREFVKAKVNEHHRDFDSDNIRDFVDTYIKEMRKGQNENSTDPQLVHVVIDLIMAGTDTTSQTLYWILLYMIIYPETQ

EQAQDEIYRTFGDSALPTAAKRKEVPFTEAVVAEVQRINSVAPLTIPRCTSNDTVMHGYDIPRGTMVHVNLWSVLRDPSL

WDEPDQFKPERFLDNQGQFMKKDAFIPFSIGRRFCLGTQLAKMELFMFTTYLLQHFTFKLPEGVPVPSTVGKLGLSNGAP

PYELCAIPK*

>fgenesh2_pg.scaffold_114000012|Brafl1

86% to fgenesh2_pg.scaffold_776000008|Brafl1

MSIFKLIVTVIHDYTNFTTVLLAVFVFLLINKLFMRSSNLPPGPRPWPLVGNLFILSQFTEWTRQYGNVFTIYYGPKPVV

VLNGYNTIQEALINKGDDFSDRPGVAFAPYGPIWKEQRKFTMMGLRDFGFGKRSLEGRILEEAEALRREIIKTDGKPFNI

FPLLRKAITNVICSIVFGARHEYEDAAFGTFLEDVDIRFRTSTVINRVYRVLRRVPILGRSSQRLHQATERMRQFVKTKV

DKHHRDFDSDDIRDFVDVYIKEMRKGQNENFTDPQLVHLVIDLIMAGTDTTSQSLYWILLYMIVYPGTQQQAQDEIYRTF

GDSALPTTAKHKEVPFTEAVIAEVQRINSVAPLTIPRCTSNDTVMYGYDIPRGTMVHVNLWSVLRDPSLWEEPDQFKPER

FLDNQGQFMKKDAFIPFSIGRRFCLGTQLAKMELFMFTTYLLQHFTFKLPEGAPVPSTVGKLGMSNGPRPYELCAIPK*

>e_gw.24.51.1|Brafl1 36% to CYP2AE1

66% to fgenesh2_pg.scaffold_114000012|Brafl1

MSALKLFVTVIHDYTNFTTVVLAVFVFLLLYKLFQKPSNLPPGPRPWPLVGNLLTLSHDSAHLQYVEWARQYGDVFTLYY

GPVPTVVINGVHTIQETLFNKPDIFSDRPRFTDGKGIIFAYYGPFWKEQRIFTMSGLRDFGFGKRSLEGKILEEAEALRK

DIIKTEGRPFNIKNMLTKAVINVICSIIFGVRHSYEDSAFQTFLEDIEVRFSTPFLINQFSPVLRHLPVLGQSAQRFHLS

QKRGEQFLKMKADEHQRDFDPSDIRDFVDIFIKEMRSGQKENFTEAQLLCIINDLISAGTDTTSHSLY

>fgenesh2_pg.scaffold_435000044|Brafl1

88% to fgenesh2_pg.scaffold_776000008|Brafl1

MSIFKLIATVIHDYTNITTALLAVFVFLLINKLFRRPSNLPPGPRPWPLVGNLFILSQDAAHIQFTEWTKQYGNVFTIYY

GPKPVVVLNGYNTIQEALINKGDDFSDRPGLNKSLGVAFAPYGPIWKEQRKFTMMGLRDFGFGRRSLEGRILEEAEALRR

EIIKTDGKPFNIFPLLRKAVTNVICSIVFGARHEYEDAAFGTFLEDVDIRLHQATERMRQFVKTKVDKHYRDFDSDDIRD

FVDVYIKEMRKGQNENFTDPQLVHLVIDLIMAGTDTTSQSLYWILLYMIVYPDTQEQARDEIYRTFGDSALPTTAKRKEV

PFTEAVIAEVQRINSVAPLTIPRCTSNDTVMYGYDIPRGTMVHVNLWSVLKDPSLWEEPDQFKPERFLDNQGQYMKKDAF

IPFSIGRRFCLGTQLAKMELFMFTTYLLQHFTFKLPEGAPVLSTVGKLGMSNGPRPYELCAIPK*

>fgenesh2_pg.scaffold_24000192|Brafl1

71% to fgenesh2_pg.scaffold_776000008|Brafl1

MSGLRDFGFGKRSLEGKILEEAEALRKDIIKMDGKPFNIKSMLTKAVINVICSIVFGVRHSYEDSAFQTFLEDIEVRFST

PFLINQFSPVLRHLPVLGRSAQRFHLSQERGEQFLKMNADEHQRDFDPSDIRDFVDIYIKEMRSGQKENFTEGQLLCIIN

DLISAGTDTTSHSLYWILLYMVIYPDIQERAQREISLMFGDSGQPTTAKRMELPFTDAVISEVMRINPVTPLTVPHCTSS

DTAIHGYDIPRGTMVHVNLWSVLRDPSLWEEPDQFNPERFLDDHGQYVKKDAFIPFSIGRRSCLGAQLAKMELFVFTTYL

LQHFTFKLPEGAPPPSTVGRLGLTNGPRPYKLCAIPK*

 

$$$$$$$

 

>fgenesh2_pm.scaffold_78000019|Brafl1 40% to CYP2U1

MRKKYGDVFSIRLGPKDVVVLCSYDAIHEAFVKKGEDFSSRPSLYVFDEMGETRNGLVFTPYGLFWKQQRKFALKSLRDF

GFGKRSLEGKILEEAERLKEEILQTANTPFNVRPLLQNAVGNVICSIVFGARFDYSDPKFNYLMERINQNFGEQDLAGMT

NFFPLLRHIPAVRKAVDKVLKNAEEVKDTLHELMIEHKNTFDPSNIRDFIDSYLLEMNRQDEEGPQEGFDENQLSHAISD

LFVAGSETTSTTLTWALLYMVLYPEVQQKVQEEIDSVVGPDKALSITQRNQLPYTEAVIAEVMRISPITAMGAIHATSND

ANLFGYEIPEGTMIFPLTWSVFYDPVHYPEPEIFKPQRFLGEHGQFVKDQTFIPFSI

VLASHLLGRKFGQDGAVPVLHPPAAALHFQATR*

>fgenesh2_pm.scaffold_421000005|Brafl1

97% to fgenesh2_pm.scaffold_78000019|Brafl1

MRKKYGDVFSIRLGPKDVVVLCSYDAIHEAFVKKGEDFSSRPSLYVFDEMGETRNGLVFTPYGSFWKQQRKFALKSLRDF

GFGKRSLEGKILEEAERLKEEILQTANTPFNVRPLLQNAVGNVICSIVFGARFDYNDPKFNYLMERINQNFGEQDLAGVT

NFFPWLRHIPAVRKAVDKVLKNAEEVKDTLHELMIEHKNTFDPSNIRDFIDSYLLEMNRQDEEGPQEGFDENQLSHAISD

LFVAGSETTSTTLRWALLYMVLYPEVQQKVQEEIDSVVGPDTALSITQRSQLPYTEAVIAEVMRISPIAAMGAIHATSND

ANLFGYEIPEGTMIFPLTWSVFYDPVHYPEPEIFKPQRFLGEHGQFVKDQTFIPFSIGRRICLGENLAKMELFLFFTHLL

QHFTFKLPDGAAKPSTVGIQGFATYSPVYYELCAIKRE*

>fgenesh2_pg.scaffold_421000045|Brafl1

82% to fgenesh2_pm.scaffold_78000019|Brafl1

MRKKYGDVFSIRMGPKDVVVLCGYEAIHEALVRKGEDFSSRPSMYLFDKTTGMKSGIAFLPYGSLWKQQRKFTLRSLRDF

GFGKRSLEGKILEEAEGLKEEILKTANTPFNVRPLLQNAVSNVICSIVFGARFDYSDPKFNYLMDRVNQNFGEQDLAGVT

NFFPLLRHIPAVRKAVDKVLKNAEEVIGSLREDLIEHKNTFDPSNIRDFIDSYLLEMSQEDEAGDRENFTEDQLNYVISD

LFVAGSETTSTTLTWALLYMVLYPEVQQKVQEEIDSVVGPDTALSITQRSQLPYTEAVITEVMRIKPVAPMSLPHATSKN

ANLFGYDIPEGTMIWPVLWSVFYDPVHYHEPEVFKPQRFLGENGQFVKDPTFIPFSTGRRMCLGENLAKMELFLFFTHLL

QHFTFKLPDGAAKPSTVGIVGIITYSPVSFDLCAIPRE*

>fgenesh2_pm.scaffold_78000020|Brafl1

81% to fgenesh2_pm.scaffold_78000019|Brafl1

MRKKYGDVFSIRMGPKDVVVLCGYEAIHEALVRKGEDFSSRPSMYLFDKTTGIKSGIAFLPYGSLWKQQRKFTLRSLRDF

GFGKRSLEGKILEEAEGLKEEILKTANTPLNVRPLLQNAVSNVICSIVFGARFDYSDPKFNYLMERINQNFGEQDLAGVT

NFFPWLRHIPAVRKAVDKVLKNAEEVVGSLREDLIEHKNTFDPSNIRDFIDSYLLEMSQEGEAGDRENFTEDQLNYVISD

LFVAGSETTSTTLTWALLYMVLYPEVQQKVQEEIDSVVGCDTVLSITQRSQLPYTEAVITEVMRIKPVAPMSLPHATSKN

ANLFGYDIPEGTMIWPVLWSVFYDPVHYHEPEVFKPQRFLGENGQFVKDPTFIPFSTGRRMCLGENLAKMELFLFFTHLL

QHFTFKLPDGAAKPSTVGIVGIITYSPVSFDLCAIPRE*

 

$$$$$$$$$

 

>fgenesh2_pg.scaffold_61000118|Brafl1 38% to CYP2U1

MMSSTLQVLDLLDIRVTLVLLLLLLFTYSYSRRPRNLPPGPWGWPVIGSLPSLAWSKNLHLDFMDWQRKYGPVTYFRMGM

LDAVVLGGYDTIRQALVKQSEVFSGRPTHLAVVNKISNNKGIVLLPSGPLWKEQRKFALTTLRSFGFGKRSLEVQITEES

AELFEQIRNMGGEPFNITRLLQKAATNIISSLVFARRFEYDDPHFLQLMRDFDAIVETNFLAMPENILPFLACVLDSGKK

VIEIFQGPENFVRAEINEHQLTFDPNDVRDFIDSYLLEMQAQDQSDTTFTEDQLLHTVLDLFVGGTETTTTTLRWASLLM

IVHPDIQRKVHEEIDSVLGHGQTPSMSHRDQLPYTQAVLTEVSRFATIAPLSVAHTTTEDTTLNGYHIPKQTIVIPSIWS

VHHDEKLFPQHDKFDPTRFLDEKGQYKKDEHVIPFSAGPRVCLGEQLARMELFLFFTALMQHFTFKTPEGAPAPSTEGRM

ATTHFPEPFDMIALVRE*

>fgenesh2_pg.scaffold_492000010|Brafl1

96% to fgenesh2_pg.scaffold_61000118|Brafl1

MMSSALQVLDLVDARVILVLPLLLLFTYMYSRRPRNLPPGPWGWPVIGSLPSLAWSKNLHLDFMDWQRKYGPVTYFRMGM

LDAVVLGGYDTIRQALVKQSEVFSGRPTHLAVVNKISNNKGIVLLPSGPLWKEQRKFALTTLRSFGFGKRSLEVQISEES

AELCEQIRNLGGEPFNITRLLQKAATNIISSLVFARRFEYDDPRFLQLMRDFDAIVETNFLAMPENILPFLGCVLDSGKK

VIEIFQGPENFVRAEINEHQLTFDPNDVRDFIDSYLLEMQAQDQSDTTFTEDQLLHTVLDLFVGGTETTTTTLRWASLLM

IVHPDIQRKVHEEIDGVLGQGQTPSMSHRDQLPYTQAVLTEVSRFATIAPLSVAHTTSEDTVLNGYHIPKQTIVIPSIWS

VHHDEKLFPQHDKFDPTRFLDEKGQYKKDEHVIPFSAGPRVCLGEQLARMELFLFFTALMQHFTFKTPEGAPAPSMKGRM

ATTHFPEPFDMIALVRE*

>fgenesh2_pm.scaffold_22000007|Brafl1

83% to fgenesh2_pg.scaffold_61000118|Brafl1

MTSAADQVLDLLDTRVTLVLLFLLLVTYFYSRRPRNLPPGPWSWPVVGSLPSLAWSQNLHLDFMDWQKKYGPVTYFRMGM

LDAVVLGGYDTIRQAIVKQSEVFSSRPAHLVVLNKMSKKKGIVMAPSGPLWKEQRKFALTTLRSFGFGKRSLEVQISEET

SALLEQIQNIGDKPFNITRPLQKATTNIISSMVFAHRFEYDNPQFLQFMQDFDDIAGTNFLAMPENILPFLQYVLDSGSK

VIKISQRLINFAQAKIKEHQQTFDPNDIRDFIDSYLLEMQAQDQSDTTFTEEQLVMTVLDLFVAGTETTTTTLRWASLLM

LVYPDIQQKVHEEIDSVLGQGQTPSMSHRDQLPYTQAVLTEVSRFATIVPLNVPHTTSEDTTLNGYHIPKQTIVIPSIWS

VHHDEKLFPQHDKFDPTRFLDEKGQYKKDDHVMPFSAGPRICLGEQLARMELFLFFTSLMQHFTFKIPEGAPTPSLKGRI

AATHFPEPFDIVAVVRD*

>fgenesh2_pm.scaffold_22000005|Brafl1

83% to fgenesh2_pg.scaffold_61000118|Brafl1

MTSAADQVLDLLDTRVTLVLLFLLLVTYFYSRRPRNLPPGPWSWPVVGSLPSLAWSQNLHLDFMDWQKKYGPVTYFRMGM

LDAVVLGGYDTIRQAIVKQSEVFSSRPAHLVVLNKMSKKKGIVMAPSGPLWKEQRKFALTTLRSFGFGKRSLEVQISEET

SALLEQIQNIGDKPFNITRPLQKATTNIISSMVFAHRFEYDNPQFLQFMQDFDDIAGTNFLAMPENILPFLQYVLDSGSK

VIKISQRLINFAQAKIKEHQQTFDPNDIRDFIDSYLLEMQAQDQSDTTFTEEQLVMTVLDLFVAGTETTTTTLRWASLLM

LVYPDIQQKVHEEIDSVLGQGQTPSMSHRDQLPYTQAVLTEVSRFATIVPLNVPHTTSEDTTLNGYHIPKQTIVIPSIWS

VHHDEKLFPQHDKFDPSRFLDENGQYKKDDHVMPFSAGPRICLGEQLARMELFLFFTSLMQHFTFKIPEGAPTPSLKGRI

AATHFPEPFDIVAVVRD*

>fgenesh2_pg.scaffold_17000026|Brafl1

63% to fgenesh2_pg.scaffold_61000118|Brafl1

MSAVHHVLELLDSRASLVLLFVSLLTYLYFRRPKNLPPGPTCWPVIGSLPSIAKVHNRCSFHELLQTFDTVVLGGYDVIY

QALVKQAEAFSSRPVHLAVVSKITKNKGIVMIPSGPHWKEQRKFALITLRSFGFGRRSMEAKILEEAAALCEEINNFGGK

PFKLPRLVQKATTNVICSLVFSHRLDYDDPNFLRLMEDFNTVSGTAFLNMPENVFPFLRHVLSSGDNLIKASKFPVDYIM

SQIRVHEDTFDKNDIRDFIDAFLLEMETQDQGTSSFTEEQLVYTVFDLFVGGTESTSDALRWASLLMMVNPDIQQKVQEE

IDGVLGPDQPPSMAHRPQLPYTQAVLAEVFRFSCIVPLIVPHTTTEDTTLNGYHIPRQTIVIPNLWSVHYDEKLFPDPYK

FDPTRFLDDKGQYKKDEHVMPFSAGPRICLGEQLARMEFFLFFTSLMQHFTFKLPEGVTVSPHEGITGGVRSPKPHDMIA

VARN*

>gw.289.34.1|Brafl1

69% to fgenesh2_pg.scaffold_61000118|Brafl1

RNLPPGPTCWPVIGSLPSIAKADELHLKFLEWQKEYGPVIYFRVGMLDTVVLGGYDVIYQALVKQAEAFSSRPVHLAVVS

KITKNKGIVMIPSGPHWKEQRKFALITLRSFGFGRRSMEAKILEEAAALCEEINNFGAKPFKLPRLVQKATTNVICSLVF

SHRLDYDDPNFLRLMEDFNTVSGTAFLNMPENVFPFLRHVLSSGDNVRQLIKASKFPVDYIMTQIKEHEDTFDKNDIRDF

IDAFLLEMETQDQGTSSFTEEQLVYTVFDLFVGGTESTSDALRWASLLMMVNPDIQQKVQEEIDSVLGPDQPPSMAHRPQ

LPYTQAVLAEVFRFSCIVPLIVPHTTTEDTTLNGYHIPRQTIVIPNLWSVHYDEKLFPNPYKFDPTRFLDDKGQYKKDEH

VMPFSAGPRICLGEQLARMEFFLFFTSLMQHFTFK

 

$$$$$$$$

 

>e_gw.1022.9.1|Brafl1 40% to CYP2U1

MFTLAEVAATVRDYVDLPTILVAMSTCLLSYLYLQRHRNLPPGPWAWPVLGNIPYLASKAVHVLYELSQKHGDVMSLWIA

RELHIVVSGYQTIRDVLVRRAEDFSSRKVPAVVVDARGDGTSTKATKGVLFAEYGPDWRQQRRFALKTLRDFGVGKRSLE

GKICEEAAAISQELVAKDGQPFYIKHLMQDSVSNIICSIVFGKRFEFGDPEFLWLIEVLNDNVDVRPAEDLLANIHPVLR

HLPFGSPEQRKLAKSTSKLQTYCRGQIETHRETFDPNDIRDFIDAFLLEQRHAGGDQTQNGFTDKQLQEIIMDLFLAGTE

TTATTMCWALLYMLLYPDIQEKAKIDSVLGQAVPSYSHRDKMPYTTATLAEVQRINSAVPLGVPHSPSRKATLKGYTIPA

DVSILSNIWSVHMDPQLFPEPRTFNPDRFLDQDGNFVKHEALIPFSVGPRVCLGEQLARMELFLLYVSLMQRFTFQLPEG

APTPSSVGNMTALINMPHPFDLCAVSRG*

>fgenesh2_pm.scaffold_110000009|Brafl1

73% to e_gw.1022.9.1|Brafl1

MCFRIASKLHVVISGHDAIRHALVTRADDFSSRKVPPTTAYIRGDGTSSKAAKGVLFAEYGPDWRQQRRFALKTLRDFGV

GKRSLEGKICEEAAALSQKLVAKDGEPFNIKPLLQNSVSNIICSIVFGKRFEYGDPEFLRIITLLNKVVETKPDRDILVN

IHPVFRHIPFVSQEEKKLTKNTLEMQEFCIHQIQQHRATFDPNDIRDFIDAFLLEQRHAGGDQTQNGFTDKQLQEVLLDL

FLAGTETTSTAIGWALFDMLLYPNVQEKASCYFLVHQEIDSVLGQAVPSYSLRDKMPYTTATLAEVQRINTILPYSVPHA

TSTDTTLNGYTIPEDAIILVNLWSVHMDPQLFPVPDKFNPGRFLDQDGNFSKHPALISFSIGPRVCLGEQLARMELFVLF

VSLMQRFTFQLPEGAPALSTPGKMTSLINMPHPHELCAVPRG*

>e_gw.110.57.1|Brafl1

96% to e_gw.1022.9.1|Brafl1

PFYIKHLMQDSVSNIICSIVFGKRFEYGDPEFLWLIEVLNDNVDVRPAEDLLANIHPVLRHLPFGSPEQRKLAKSTSKLQ

TYCRGQVETHRETFDPNDIRDFIDAFLLEQRHAGGDQAQNGFTDKQLQEIIMDLFLAGTETTATTMCWALLYMLLYPDVQ

EKAKVHREIDSVLGQAVPSYSLREKMPYTTATLAEVQRINSAVPIGVPHSPSRKATLNGYTIPADVSILSNIWSVHMNPQ

LFPEPRTFNPDRFLDQDGNFVKHEALIPFSVGPRVCLGEQLARMELFLLYVSLMQRFTFQLPEGAPTPSSVGNMTALINM

PHPFDLCAVSRG*

>e_gw.1022.6.1|Brafl1

72% to e_gw.1022.9.1|Brafl1

LTDLSKTYGDVMCFRIASKLHVVISGHDAIRHALVTRAEDFSSRKIILYLGVLFAEYGPDWRQQRRFALKTLRDFGVGKR

SLEGKIYEEAAALSQELVAKDGQPFNIKPLLQNSVSNIICSIVFGKRFEYGDPEFLRIITLLNNLVDSKPGRDILVNIHP

VFRHIPFVSQEEKKLTKNTLEMQEFCSQQVQQHRETFDHNDIRDFIDAFLLEQRHAGGDQARNGFTDKQLQEVLLDLFLA

GTETTSTAIGWALFDMLLYPDIQEKAKIDSVLGQAVPSYALRDKMPYTTATLAEVQRINTILPYSVPHATSTDTTLNGYS

IPEDAIILVNLWSVHMDPQLFPEPDKFNPDRFLDQDGNFTKHPALISFSIGPRVCLGEQLARMELFVLFVSLMQRFTFQL

PEGAPALSTPGKMTSLINMPQPYELCAVSRG*

>e_gw.110.103.1|Brafl1 39% to CYP2U1

68% to e_gw.1022.9.1|Brafl1

MDTFPFLVAACVCLMTYWYLQTPRNLPPGPWAWPVLGNIPLFMTSKFDFFPDTITDLARQYGDVMTFWNARDLNVVISGY

RTIRTVLVKRAEDFSSRKAPPVLRSILIHQCIVFADFGSDWKNQRKFAMKTLRDFGVGKRSLEGKICEEAAALSQELVAK

DGEPFNIKHLLQNTVSNIICSIVFGKRFEYGDPEFLRLSHLISEVIDATPGKDILINIHPVFRHLPFGSQEHQKLARNFP

KLQAFCGEQIKKHRATFDPNDIRDFIDAFLLEQQHAGREHAQYSFTDEQLQELVLDLFMAGAETTATSLHWALLYMLLYP

GIQEKVQGEIDSVLGQAVPSYPLRDKMPYTTATLAEVQRINTVAPFSVPHSLSTGASLNGYTIPAGANILVNLWSVHMDP

QLFPEPGKFNPDRFLDQDGNFVKHEALIPFSVGPRVCLGEQLARMEIFLLFVSLLQRFTFKPPEGVTNLSTVGTMTGIVN

APRPYDLCAFLRQ*

>e_gw.303.4.1|Brafl1 40% to CYP2U1

93% to e_gw.110.103.1|Brafl1

MECLTEILTTVYRYLDMSTLLLAACVCLMTYWYLQTPRNLPPGPWAWPVLGNIPLFMKSKFDFFPDTITDLAWQYGDVMT

FWNARDLNVVISGYRTIRSVLVKRAEDFSSRKAPPVLFYFVKDKSIIFADFGSDWKHQRKFAMKTLRDFGVGKRSLEGKI

CEEAAALSQELVAKDGEPFNTKPLLQNSVSNIICSIVFGKRFEYGDPEFLWLSHLISEVVNATPGKDILINIHPVFRHLP

FGSQEHQKLARNFPKLQAFCGEQIKKHRATFDPNDIRDFIDAFLLEHQHAGREHAQYSFTVEQLQELVLDLFMAGAETTA

TSLHWALLYMLLNPGVQEKVQGEIDSVLGQAVPSYSLRDKMPYTTATLAEVQRINTVAPFSVPHSLSTGASLNGYTIPAG

ANILVNLWSVHMDPQLFPEPDKFNPDRFLDQDGNFVKHEALIPFSVGPRVCLGEQLARMEIFLLFVSLLQRFTFKPPEGV

TNLSTIGTMTGIVNAPRPYDLCALPRQ*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_182000030|Brafl1 36% to CYP2J2

MVDGAFSEIFQLSGLNLQTFLVFFLAFLLACLYLRRPRNLPPYPAGCWPVLGHLLALGRAPHLQLTAWRRQYGDVFTVRM

GMEDVVVLNGYTAVKDALVDRSELFASRPQNYIFDLINGFGKAIVSTQWGKAFKQKRKFASTILRTLGVKEGMGSIEEKI

REETGFLCAKVAKYGGQPFDPESDLHFTIANVICSIVFGNRFDYGDGRFRDLSDAVLVTMDRLGAGQIINVFPFLRFVPG

VNMSLHDVKKYNEKIHAFLWDEISCHRQKLDRENPRDFLDCCLVELEKGEKIEYFTEEHVMYMTFELLFGGLDTLTSTVR

WCLLYMVLYPDVQKKVQSELDAVVGGAQPALSHRAQLPYTEATLMEVQRMRAVAPLGLPHSTTQDVTFGEFDLPAG

VMVYRLYVNTLH*

>fgenesh2_pg.scaffold_182000033|Brafl1 green = 40% to CYP2D7P1

90% to fgenesh2_pg.scaffold_182000030|Brafl1

MSSTGTGRDVTVLIPLCKANPDKEADLRKCPTVRVKHVIFDCIDEKETLMDYVQRLKKVVKENDVSVVLPTTDLSTFAHA

ALARDFPHIPGPSVESCYLAFHKPYTRKHLDFAEMPTPYDVLDLDSPTLLQDAAKALETVGLPAFVKSGTATLAYGLKKI

ESYDDLKDALIDFKTMRDEHPDFMFAPSAAFYRDYFTEYLDVKKYPLALCDVVLVEPFLDAETLCTMDGCVVNGKLVHWT

ITDELQYEGHEAKFTSMLGPTNEPQDVQTRMWKIYDDIMAKMIECGFNDGYTNIEIFKMKDGKLRLCEVNARGSRLVQGI

YRQVYENANQDYVYLAAGTGLVPATPPPTGRHGVAYMAKFLGHQERPGDFLDFDKIAQLKSDPDVYISPYYKRDDELADI

PGCWPILGHLLALGRAHHLQLTAWRRQYGDVFTVRMGMEDVVVLNGYAAVKDALVDRSELFASRPQNYIFDLINGFGKAI

VSTQWGKAFKQKKRFVSTTLRTLGVKEGMGSIEEKIREEMGCLCAKAQAEGGGAAGGESSSAPRQRHPSLQDQMNKVLTP

VEKFHLPSVSPIPTHSSRVKQLHVDEDDYQEAPRSPLPLIRDCPTPSPRPSRRFDWDSPETHRNVHLHVHHPLKTHIHRR

YSSPSIEDTDVSKPRKGSKRHRKEKPKDAKKPCDVEMVMIDVDNGSEDVKEKEEEKAETSDSTKASIVRTDSYEAAVRGF

PDLGATAESEESLTSKLCKEPSNASIKAPSKTSSKESIQDTASSEVSGSDALQEKTPGESVEEPETVTSAITEARASPEP

SSSKESATSLGSAKAALAKVLARKDSGRESNSDADPNVRPSPSQVALLRGDISRENSSKELKSILKNSSSFKTREDSQKS

LVDGADAVAAGDNTGDVDVTASQKKATFIIGGDVEEDDHEEAVFTLVTTAEEDAKNSEADDRLNEMPHFREGEKDAYKRK

SHRHHHGHHHSHHHGHHHHHHHHHKKVPTPMDRLRIGSMTKMDAEIYHKMPTEQEEAQKLLTPDLNEMISHRLEDVPGRR

RHRIKKPNVSSMVYIGKQSKPQKKISVQAKKSLDRSPHEVFVELDTLHATGEEGELVWNESARWIKFEEDVQQGAERWGK

PHVSSLSFHSLLELRKGLEQGSVLLDLNETELPNIMHHVVENMIITDQVRPEDRGDIMRALLLKHSHLYQKKRHKVIPYN

FSSGSLLGFLGHREDSMASTSQYSGGCPSATSLDAMEAGLKVALPDNNNQFTVPVAVTPTLHKSPTAKSTLSTKSTQMDI

KAKVPILKKIPEDAEATTVLVGAVDFLDKPTMAFVRLARGVEIGTLTAVPLPVRFLFVLLGPTSGATDYNDIGRSISTLM

ANETFHEMAYRADDRSDLLRGINEFLGDSIVLPPGDFDRRLLEPIARLQRKRLRRRRQKLQDEDGVLKKSVSHEPEDDPL

RRTGECFGGLKRDIQRRFPYYVSDFVDGLNFQCLMAFFFIFFTCVTPVITFGGLLSDKTHNHIGVSEMIIATAISGGLFS

LLAGQPIIIIAATGPFLVYDQSLYEFCESNGIEFMTWRLWIGLWILVICIITVAFEGGVFVRYVTRFTEEVFAFLISFIF

IYEVFKFLSKVYTKNPLCSDCYYYDESIGPPVFNRNGSLLVNTTIPSIESLMNSQSNNSRRMPMPAAVGPAYLNPYADPD

GYEAKETKNQPNTALMSTILCFGTFFIAYFLRKFKNSKFLSRGKLEVPDGFTPTDPKLRGWIINPMGKDKTIQVWAIFAA

VIPAFLVYILLFIEIQITEMIINKKENNLKKGSGYHLDLLLICGTVAISGFFGLPWMCAATVRSVSHFESLTVYSKTHAP

GEKPKLLSVKEQRLTNLLVHIMMGITMTLQPVLRRIPLAVLFGVFLYLGITSLAATQIFERIGLMFMPPKHHPSSVRYVR

KIFERIGLMFMPPKHHPSSVRYVRKVKTRKIHIFTVIQLVFITLLWIVKSTQAAMMFIDCLFFCILSPVIQLVFITLLWI

VKSTQAALAFPFLLILLIPFRNHVMKKFYTETEMEALDAESDGDDDDEDVDAYDTARLPF*

>fgenesh2_pg.scaffold_182000032|Brafl1

85% to fgenesh2_pg.scaffold_182000030|Brafl1

MSSTGTGRDVTVLIPLCKANPDKEADLRKCPTVRVKHVIFDCIDEKETLMNYVQRLKKVVKENDVSVVLPTTDLSTFAHA

ALARDFPHIPGPSVESCYLAFHKPYTRKHLDFAEMPTPYDVLDLDSPTLLQDAEKALETVGLPAFVKSGTATLAYGLKKI

ESYDDLKGALIDFKTMRDEHPDFMFAPSAAFYRDYFTEYLDVKKYPLALCDVVLVEPFLDAETLCTMDGCVVNGKLVHWT

ITDELQYDGHEAKFTSMLGPTNEPQDVQTRMWKIYDDIMAKMIECGFNDGYTNIEIFKMKDGKLRLCEVNARGSRLVQGI

YRQVYENANQDYVYLAAGTGLVPATPPPTGRHGVAYMAKFLGHQERPGDFLDFDKIAQLKSDPDVYISPYYKRDDELADI

PACLYL

RRPRNLPLYPAGCWPVLGHLLALGRAPHLQLTAW

(gap) 39% to CYP2U1

RRQYGDVFTVRMGMEDVVVLNGYTAVKDALVDRSELFASR

PQNYIFDLINGFGKAIVSTQWGKAFKQKKRFVSTTLRTLGVKEGMGSIEEKVREEMSCLCAKVAEYGGQPFDPESDLHFT

IANDICSVAFGSRFDYGAERFKNLSDAALVTMDRVGSGQIINVFPFLRFVPGVNKSLRDVSKYNAKIHAFLWDEISRHRQ

NLNRENPRDFLDFCLVELERREKVEDFTDEHVMYMTYELLFAGLDTVANAMRWCLLYMVLYPDVQKKVQSELDEAVGGAQ

PALSHRAQLPYTEATLMEVQRMRAVAPLGLPHATTQDVTVGEFDLPAGVMVLTNLHSLHMDPAYWPDPDRFDPERFLDAE

GKVINKPKSFMPFSGGRRGCLGEQLAKMELFLLFSSLLQNFTFKSPEGAPALSVEGDMRLTLTPPSYKIRAIPR*

>e_gw.91.310.1|Brafl1 45% to CYP2U1

96% to fgenesh2_pg.scaffold_182000032|Brafl1

KSLRDVSKYNAKIHAFLWDEISRHRQNLNRENPRDFLDFCLLELERREKVEDFTDEHVMYMTYELLFAGLDTVANAMRWC

LLYMVLYQDVQKKVQSELDTVVGGAQPALSHRAELPYTEATLMEVQRMRAVAPLGLPHATTQDVTLGEFDLPAGVMVLTN

LHSLHMDPAYWPDPDRFDPERFLDTEGKVISKPKSFMPFSGGRRGCLGEQLAKMELFLLFSSLLQNFTFKSPEGAPALSV

EGSMRLTLTPPSYKICAIPR*

>fgenesh2_pg.scaffold_182000029|Brafl1 green = 32% to CYP2U1

67% to fgenesh2_pg.scaffold_182000030|Brafl1

MAATTTIAKKTTTPMRADTALLLVAEGGIFWNVEVTFLVFCLALFLAYLFLKGTKNLPPYPAGCWPVLGHLLALGRAPHL

QLTAWRRQYGDVFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPNYIFDVVTGFGKDMTGERWGNLFTQKKYFTTIA

LKTLGRDDFDDGPDAIEEKIREEAGCLCNKEDVDVTIANVICSMLCGERFEYGDRRFRELSEAVANTMDKLGCGQPISVF

PFLRFIPGVNKPISGSKLHAGKIQKFLWDEISRHRQDLDHENPRDFLDVCLIEADTHDKVDNLTEENIVYIAQDLFLAGI

DTITHTLRWSLLYMAMNPDIQEKVQSELDAVVGGAQPALSHRAQLPYAEATLMEVQRMRAVVPLGLPHATTQHVKVGQFD

VPAGTQVVTNLHSLHMDPAYWPDPDRFDPERFPDAEGKVINNPKSYMPFSG AVVTANIDYVYHNYTELTRVLGETAFQCP

GIMQVYTVGTSVQGRELWVMEISDNLGDHEPGEPEFKYVGNMHGNEVVGREILVYLIQYICQQYQAGDSRIRSLVHETRI

HIMPSMNPDGFEYAEAYTPPTNPNETDWTYLAGRYSFFDNGERYDGFNGTDLNRNFPELNSVVYRYENTSGPNHHLSVPD

DFWTGNTVSLRPAPETKLVMDWILRYPFVLSANLHGGEVLANYPYDLSRTYPNNPTAYTRCPDDEVFRELSKAYSLAHGT

MAKCGVTQPCYTDDFACQDGITNGAAWYSTTGCMQDFNYLASNCFEITLELSCNKFPPEAELVQFWEDNREALLQYMEKV

HSGIKGFVRDTNNNGIADAVISVRGINHDVTTARDGDYWRLLVPGTYRVTASWGGWTQEKTCTAANRAGVCDFVLGAPPT

QPPSTSAASPAMPLMWSSVLAIAALVFSWLRP*

>fgenesh2_pg.scaffold_399000001|Brafl1 42% to CYP1A1

78% to fgenesh2_pg.scaffold_182000029|Brafl1

MEMGRNVVRVIRKTLGMDEFSELEIMKVCGILTRWWPVFGHLFSLGRAPHLKFTEWRRQYGDVFTVRFGLNDVVVLNGYT

VVKDALVSRSELFASRPPSYVFDIITGVGK

 

$$$$$$$$

 

>estExt_fgenesh2_pg.C_610015|Brafl1 34% to CYP1A1, 34% to CYP2U1

MWLMTITVGLVTLVLATWLRDYVKRWRMPPGPFFWPIIGNIYFFSGRMYTTCTDLAKKYGDVFSLKMGMTDVVVLNSLDT

VKEAFVKKGVDFAGRPKILSMDIFSEGGKDIAFTDYSPTWKLHRKLFHGAIRGYALGENLQTRVHESLEDTIAEFTKMEG

QAVNIEDYIYQLVYNVICSAAFGVRYTMDDEEFNTLMKINKDTEEIVGQGLLADVYPSLRFLPSPTLTNIRKMTKQYVGI

MQRHLEEHRETFDPSNLRDITDHMIKAQKDAEEEGIQDINSLTDTHLRQTISDIFGGGTDTTIFTLRWAILYLAVHPEIQ

EKVAAELDSVVGRDRLPELSDREATPYTEATILEVMRMGSIAPLSLPHATTVDTTLRGYQIPKGTWVVPNLWALHRDPDT

WGDPDVFRPERFLDENGKPVPKPAALMPFSAGRRACPGEAVGKADTFLLLGGLVQNFSFSIPEGEGPPDLTPDDKAGGET

LNTPSARTTVSPDVVKHLR*

>estExt_GenewiseH_1.C_6820014|Brafl1 35% to CYP1A1

97% to estExt_fgenesh2_pg.C_610015|Brafl1

MWLMTITVGLVTLVLVTWLRDYVKRWRMPPGPFFWPIIGNIYFFSGRMYTTCTDLAKKYGDVFSLKMGMTDVVVLNSLDA

VKEAFVKKGVDFAGRPYILSMDIFSEGGKDIAFTDYSPTWKLHRKLFHGAIRGYALGENLQTKVHESLEDTIAEFTKMEG

QAVNIEDYIYQLVYNVICSAAFGVRYTMDDEEFNTLMKINKDTEEIVGQGLLADVYPSLRFLPSPTLTTIRKMTKQYMGI

MQRHLEEHRETFDPSNLRDITDHMIKAQKDAEEEGIQDINSLTDTHLRQTISDIFGGGTDTTIFTLRWAILYLAVYPEIQ

EKVAAELDSVVGRDRLPELSDREATPYTEATILEVMRMGSIAPLSLPHATTVDTTLRGYQIPKGTWVMPNLWALHRDPDT

WGDPDVFRPERFLDENGKPVPKPAALMPFSAGRRACPGEAVGKADTFLLLGGLVQNFRFSIPEGEGPPDLTPDDKTGGDT

CIPYPYKVVMTCR

>e_gw.682.1.1|Brafl1

95% to estExt_fgenesh2_pg.C_610015|Brafl1

MWLMTITVGLVTLVLATWLRDYVKRWRMPPGPFFWPIIGNIYFFRVLEHLNYAQLPRKYGDVFSLKMGMTDVVILNSLDA

VKEAFVKKGVDFAGRPMILSMDIFSEGGKDIAFTDYSPTWKLHRKLFHGAIRGYALGENLQTRVHESLEDTIAEFTKMEG

QAVNIEDYIYQLVYNVICSAAFGVRYTMDDEEFNTLMKINKDTEEIVGQGLLADVYPSLRFLPSPSESLTNIRKMTKQYV

GIMQRHLEEHRETFDPSNLRDITDHMIKAQKDAEEEGIQDINSLTDTHLRQTISDIFGGGTDTTIFTLRWAILYLAVHPE

IQEKVAAELASVVGRDRLPELSDREATPYTEATILEVMRMGSIAPLSLPHATTVDTTLRGYQIPKGTWVVPNLWALHRDP

DTWGDPDNFRPERFLDENGKPVPKPAALMPFSAGRRACPGEAVGKADTFLLLGALVQNFRFSIPEGEGPPDLTPDDKAGG

TTCIPYPYKVVMTCRK*

>e_gw.44.179.1|Brafl1

84% to estExt_fgenesh2_pg.C_610015|Brafl1

MTIAAGIVTLLLLTWLRDYMKRWRMPPGPFFWPIIGNIYCNGRMYITFIDLAQKYGDVFSLKMGMTDVVVLNSLDAVKEA

FVKKGVDFAGRPKILSNEILTEGGKDIAFTDYSPTWKLHRKLFHGVTHWGQNLQTKVHESLEDTIAEFSKMEGQAVDLEG

YIYKLVYNVICSTAFGVRYNMDDEDFITLMKISKDMTETLGQGLLADVYPSLRFLPSPGESLTAFRKMTEQSLTILQRHL

EEHRETFDPSNLRDITDHMIKAQKDAEEEGIQDINSLTDTHLRQTMNDVFAGGTDTTIWTLRWANLYLAAHPEIQEKVAA

ELDSVVGRDRLPEMSDREAMPYTEATIHEIMRMGSIAPLSLPHATTVDTTLSGYQIPKGTWIMPNLWALHHDPDTWGDPD

VFRPERFLDEDGKPIPKPAALMPFSAGRRACPGDAVAKAVTYLLLGGLVQNFRF

>fgenesh2_pg.scaffold_44000076|Brafl1

84% to estExt_fgenesh2_pg.C_610015|Brafl1

MMEGYVSSQTVCAKARNETSRRHRGGTSEADAGPGRVFSGRMYLTFIDLAKTYGDVFSLKLGMTDVVVLNSLDAVKEAFM

KKGADFAGRPKMLSMDISSEGGKDIVFTDYNPTWKLHRKLFHGAIRGYASGQNLQSKVHESLKDTIAEFTKMEGQGVNLD

DYLYQLVYNVICSAAFGVRYNMDDENFKTLMKVSKDAAERFGQGFLADVYPLLRFLPSPTVTACRKMMDQILGIMQCHLE

QHKETFDPSNRRDITDHMIKAQKDAEEEGIQDINSLTDTHLRQTISDIFFGGTFSSIFSLRWALLYLAVHPEIQEKVAAE

LDSVVGRDRLPELSDREATPYMEATIHEVMRMASMDPLSLPHATTVDTTLRGYQIPKGTMVMPNLWALHHDPDTWGDPDV

FRPERFLDENGKPVKPAALMPFSAGRRACPGETLGKANNFLLLGGLVQNFRFSISKGEGPPDLTPDEKGGGASCIPSPYK

VVMTCRK*

>gw.736.1.1|Brafl1

84% to estExt_fgenesh2_pg.C_610015|Brafl1

YLTFIDLAKTYGDVFSLKMGMTDVVVLNSLDAVKEAFVKKGEDFAGRPKMLSTDISSEGGKDIAFADYSPTWKLHRKLFH

SAIRGYASAQNLQSKVHESLEDTIAVFSKMEGQAVDLEDYIYQLVYNVICSAAFGTRYNMDDEDFNTLMKISKDTTETFG

QGLLADVYPLLRFLPSSSVTANRKMTHQLMEIMQRHLEQHRESFDPNNLRDITDHMIKAQKDAEEEGIQDIDSLTDTHLR

QLIGDIFFAGTISTILTLRWAILYLAVHPEIQEKVAAELDSVVGRDRLPELSDREATPYTEAIFHEVMRMASMDPVSLPH

ATTVDTTLRGYQIPKGTWILPNLWALHHDPDTWGDPDVFRPERFLDESGKPIPKPAALMPFGVGRRACPGEALGKADTFL

LLGGLVQNFRFSIPEGEGPPDL

>estExt_fgenesh2_pg.C_440080|Brafl1

70% to estExt_fgenesh2_pg.C_610015|Brafl1

MLMVTIFLGLLTLIFATWLLGYIRRWRMPPGPFYWPIIGNITMFGGRTYLTFIDLAQKYGDVFSLKLGMTDVVVLNSLDA

VKEALVKKSADFGGRPKTLTSDIVTEGGQDIAFTGNSPTWKLQRKLFVSAVRTYASGRNLETIVHESLEDIIADFTNMEG

EPVDLEDYIYKVVYNIICAASFGVRHKMDDSDFQHLLQTNKEGVEILSKGLLADIYPSLAFLPTPAKRACHEMSCNFLKY

FKRQVDQHQETFDPDNLRDITDHLIKAQKEAEEEGIQDINSLTDTHLRQTVGDIFGGGTNTTIHTLRWAILYLAAHPEIQ

EKVAAELDSVVGRDRLPELSDREATPYTEATMHEVMRMGSVTPTSLPHATTVDTTLRGYHIPKGTWIFPNLWALHYDPDI

WGDPDTFRPERFLDDNGRPIPKPAALMPFRNPPQAECWTSCLPRRGCGKADMFLLLAGLVQNFRFSIPEGGGPPDLTPDV

RGGGFVSMPVPSKIVITCRK*

>e_gw.44.180.1|Brafl1

73% to estExt_fgenesh2_pg.C_610015|Brafl1

MTITVGLVTLILIKWLKDYVQRWRMPPGPFFWPIIGNLSLFGGKSYLTFIDLAKTYGDVFSLKLGMTDVVVLNSLDAVKE

AFVKKGEDFAGRPKMLTTDISSEGGKDIAFSDYSPTWKLHRKLFHSAIRGYASGQNLQSKVHESLEDTIAVFSKMEGQAV

DLEDYIYQLVYNVICSAAFGIRYNMDDEDFNTLMKISKDTTETFGQGLLADVYPLLRFLPSSIYERVDGCCHDFWHVNSL

SKDLYNVILMQINSLFAKLIRKTQEEFLLLKSVTLVGLTGVILDLLGPVAILSSAGTISTILTLRWAILYLAVHPEIQEK

VAAELDSVVGRDRLPEMSDREAMPYTEAIFHEVMRMASMDPVSLPHATTVDTTLRGYQIPKGTWIMPNLWALHHDPDTWG

DPDVFRPERFLDENGKPIPKPAALMPFGVGRRACPGEALAKADTFLLLGGLVQNFRFS

>estExt_fgenesh2_pg.C_1010038|Brafl1

63% to estExt_fgenesh2_pg.C_610015|Brafl1

MASWTTWLMTVLVGLATLVLVSWVLDIIKRRRMPPGPFFWPIIGNIFMFGGQFYLTFVELGKKYGEVFSLKLGMIDVVVL

NSLEVIREALVKKGADFAGRTQTATGDLVSEGGKDIVMGDFNPTWKLQRKLFHGAVRAYATGRTLEEKVQGSLNEVIEEF

SSLEGKPVDVEDHVFKMVCNVVCSATFGHRYKMEDEDFQLLIKITHEFLDIGTQGMLADIYPSLAFLPTPTKTTMTKLLN

EFLEYFKRELDQHIQTFDPDNLRDITDHFIKLQKEAEEEGDADINSLTDTHIRQTIVDIFGAALDTTVQSMRWALLLLAA

HPEVQEKLATELNGVVEPDRQPALADRPALPYMDATINEVLRFGIVVPLSLPHATTVDTTLRGYEIPKGTWVMPNLWNAV

RDPEIWGDPNVFRPERFLDDDGKVLPKPSALMPFSAGRRACPGEPMARADIFLMLAGLVQKFKFSLPEGEGSPDLTPDPK

GAGLFCIACPYKVVMTYRK*

>e_gw.438.6.1|Brafl1

60% to estExt_fgenesh2_pg.C_610015|Brafl1

MTVLVSLTTLVLVSWVLDIIKRWRMPPGPFFWPIIGNLFLFGGQFYLTFIELGKKYGDVFSLKLGMRDVVVLNSLEVIRE

ALVKKGADFAGRTQTVTGDLMSEGRKNIAQGDFTPTWKLQRKLFTETAVPLSRAYATGHALEDHVQGALNDIIAEFSSLE

GKPVDVEGHIFKLVCNVSCSASFGYRYKMEDPDFQNLLKISQDFLEIGSQGMLADIYPSLSFIPTPTKTTLTKMFGTFLE

YFKRQLDQHLQTFDPENLRDITDHFIKLQKEAEEGGDKDISSLTDTHIRQTVVDILAGAIDTLVQTMRWSLLLLAAHPEV

QEKLAAELDSIVEQHRQPALSDRTALPYMDATINEILRFGIVAPIAVPHTTTVDTSLRGYKIPKGTWVMPNLWNVVRNPV

IWGDPEVFRPERFLDDDGKVLPKPSALLPFSAGRRACPGEPMARADMFLMLGGLVQKFKFSLPEGEGPPDLTPDPKGAGL

FSLASPYKVVMTRRK*

>estExt_fgenesh2_pg.C_440079|Brafl1

63% to estExt_fgenesh2_pg.C_610015|Brafl1

MSVLHCLSSRDGPYVYCKYRSSLTSFILRKMWLTTISASLLVVLFVTWFMEYIKRWRMPPGPFPWPIIGNLPMFAGKSHL

TFIDLAKKYGDVFSLKQGMTDVVVLNSVDAVREALVEKSVQFAGRPHLQSLDIRTEGRRNMAFADYSPAWKQHRKLVKSA

LREYASDTKLETKAHEALRDIIDELAKVEGQAVDLNVHIFNLVYNVVCPVVFGVRFRMEDEDFQNLMKFSDDLLKKDPPL

GDIYPSIGFLPNRADNLRDVTDHMIKAQKEAEEDGAHDITALTDTHLRQIVADVFLGGTETTTQVLRWAILYLAAHLEIQ

EKVTAELDRVVGRDRLPELSDRQNTPYTEATVNEVLRMGLIDPLSLPHATTVDTSLRGYHIPKGTVVLPNLWALHHDPAI

WGDPHTFRPERFLDETGKLIPKPFALMPFSVGRRACPGDKMGMADTYLLLGGLVQNFHFSFPKGERPTDFSSDETGGGNV

CQPAPYKVVLTYRK*

>estExt_fgenesh2_pg.C_1800040|Brafl1

61% to estExt_fgenesh2_pg.C_610015|Brafl1

MWLITLSVSLLVVMFVNWLMDYIKRWRMPPGPFPWPIIGNLSMFSGKSHLTFIDLAKKYGDVFSLKRGMTDVVVLNSVDA

VREALVEKSVAFAGRPHLQSTEIMSEGRRDMAYTDYSPAWKQHRKLIKSALRECASDKKLETQAHAALRDIIDELVSVES

QAVDLHMHINNLVYNVVCPIAFGVRFDLENEDFQHLAGTEEDTYSNSPVGDIYPSLRFLPNRAKTNLQKLTGPFVEYFKH

QVDRHRQEFNPDNPRDVTDHMIKAQKEAEEDGAHDITALTDTHLRQIVVDVFSGGTETTTHALRWAIQFFAAHPEIQEKV

AAELDSVVGRDRLPGLGDRQNTPYTEATVNEVLRMGIPDPLSLPRATTQDTSLRGYHIPKGTMVLPNLWALHHDPDIWGD

PHTFRPERFLDESGKLMPKPFAWMPFCVGRRACPGEKMGMADTYLLLGGLVQNFHFSFPGGERPDDADAPYKVVVTCRK*

>fgenesh2_pg.scaffold_3000254|Brafl1 36% to CYP1C2

81% to estExt_fgenesh2_pg.C_1800040|Brafl1

MANAPGPFPWPVIGNLSMFSGKSHLTFIDLAKKYGDVFSLKKGMTDVVVLNSVDAVREALVEKSVAFAGRPHLQSYAIES

EGRKNMAFTDYNPTWKQHSKLMKSALREYASDRNLETQAHEAFRYIVGELEKVEGQAVDLNAHISNLIYNIVCPVAFGVS

VG RRACPAQKMGLADTYLLLGGLVQNFHFSFPGGERSPDADALAKVIVTCRK*

>e_gw.3.222.1|Brafl1 43% to CYP2U1

89% to estExt_fgenesh2_pg.C_1800040|Brafl1

IQEKVAAELHTVVGRDRLPGLGDRHDTPYTEATVNEVLRMGIPDPLSLPRATTKDTSLRGYHIPKGTVVVPNLWALHHDP

DIWGDPHTFRPERFLDETGKLIPKPSAWMPFCVGRRACPAQKMGLADTYLLLGGLVQNFHFSFPGGERSPDADALAKVIV

TCRK*

>fgenesh2_pg.scaffold_180000036|Brafl1 31% to CYP1A1

96% to estExt_fgenesh2_pg.C_1800040|Brafl1

MTDVVVLNSVDALREALVEKSVAFAGRPHLQSSEIMSEGRRDMAYTDYSPAWKQHRKLVKSALRECASDKNLETQAHVAL

RDIIDELVSVESQAVDLHMHINNLVYNVVCPIAFGVRFDLENEDFQHLAGTEEDTYSNSPVGDIYPSLRFLPNRAKTNLQ

KLTGPFVEYFKHQVDRHRQEFNPDNPRDVTDHMIKAQKEAEEDGAHDITALTDTHLRQIVVDVFSGGTETTTHALRWAIQ

FFAAHPEIQEKVAAELDSVVGRDRLPGLGDRQNTPYTEATVNEVLRMGIPDPLSLPRATTQDTSLPDSWVPSG

DLPVDFT

VTFTAPETVYNVCNRNFTQRCNFEVANFMSTNNLTTVGYVTMVAGVDGYSRWSYENNPALGQNEASACQGFDGYDPCPTA

PPGSGSVNVMMSLSTAMASAWCLVLSIFVLN*

>fgenesh2_pg.scaffold_115000064|Brafl1 32% to CYP2U1

80% to estExt_fgenesh2_pg.C_1800040

MANAPGPFPWPVIGNLSMFSGKSHLTFIDLAKKYGDVFSLKKGMTDVVVLNSVDAVREALVEKSVAFAGRPHLQSYEIES

EGRKNMAFTDYNPAWKQHSKLMKSALREYASDRNLETQAHEAFRYIIGELEKVEGQAVDLNAHISNLIYNIVCPVAFGVR

FDLKSEDFKNMTKRSEELNKKRPLGDIYPSLGFLPHRDEIESEGRKNMAFTDYNPAWKQHSKLMKSALREYASDRNLETQ

AHEAFRYIIGELEKVEGQAVDLNAHISNLIYNIVCPVAFGVRFDLKSEDFKNMTKRSEELNKKRPLGDIYPSLGFLPHRD

DMRDVTDHMIKAQKEAEEDGAYDISALTDTHLRQIVYDVFMGGTETTKLALLWAIPSLAAHPEIQEKVAAELHTVVGRDR

LPGLGDRHDTPYTEATVNEVLRMGIPDPLSLPRATTKDTSLREYNLPL*

>fgenesh2_pg.scaffold_438000023|Brafl1

59% to estExt_fgenesh2_pg.C_610015|Brafl1

MASWTMWLMTVLVSLTTLVLVSWVLDIIKRWRMPPGPFFWPIIGNLFLFGGQFYLTFIELGKKYGDVFSLKLGMRDVVVL

NSLDVIREALVKKGADFAGRTQTVTGDLMSEGRKNIAQGDFTPTWKLQRKLFTGAIRAYATGHALEDHVQGALNDVIAEF

SSLEGKPVDVEGHIFKLVCNVSCSASFGYRYNMEDPDFQNLLKISQDFMEVGSQGMLADIYPSLSFIPTPTKTALTKMFG

KFLEYFKRQLDQHLQTFDPENLRDITDHFIKLQKEAEEGGDRDIRSLTDTHIRQTVVDILAGAIDTLVQTMRWSLLLLAA

HPEVQEKLAAELDSIVEQHRQPALSDRTALPYMDATINEILRFGIVAPIAVPHTTTVDTSLRGYEIPKGTWIMPNLWNVV

RNPVIWGDPEVFRPERFLDGDGKVLPKPSALLPFRADLFLMLGGLVQKFKFNLPKGEGPPVLTPDPKGAGLFSLASSYKV

VMTRRK*

>fgenesh2_pg.scaffold_1142000003|Brafl1

76% to estExt_fgenesh2_pg.C_610015|Brafl1

MKSPLPYVVWFLTMFSGKSYLTFIDLAKTYGDVFSLKMGMTDVVVLNSLDAVKEAFVKKGEDFAGRPKMLTTDISSEGGK

DIAFSDYSPTWKLHRKLFHSAIRGYASGQNLQGKVHKSLEDTIAEFSKMEGQAVDLEDYIYQLVYNVICSAAFGIRYNMD

DEDFNNLMKISKDTTETFGQAGTISTILTLRWAILYLAVHPEIQEKVAAELDRVVGRDRLPELSDREATPYTEAIFHEVM

RMASMDPVSLPHATTVDTTLSGYQIPKGTMVMPNLWALHHDPDTWGDPDVFRPERFLDENGKPIPKPAALMPFGVGRRAC

PGEALAKADTFLLLGGLVQNFRFSIPEGEGPPDLTPDEIGEGGISIPYPYNVVMTCRK*

>e_gw.61.232.1|Brafl1 35% to CYP17A1

89% to estExt_fgenesh2_pg.C_610015|Brafl1

MYTTCT DLAKKYGDVFSLKMGMTDVVVLNSLDTVKEAFVKKGVDFAGRPMILSMDIFSEGGKDIAFTDYSPTWKLHRKLF

HGAIRGYALGENLQTKVHESLEDTIAEFTKMEGQAVDLEVYIYKLVYNVICSAAFGVRYTMDDEEFNTLMKINKDTEEIV

GQGLLADVYPSLRFLPSPSECILRTLYSTIDSSSHGLFQKIVFFTVGNLRDITDHMIKAQKDAEEEGIQDINSLTDTHLR

QTISDIFGGGTDTTIFTLRWAILYLAVHPEIQEKVAAELDSVVGRDRLPELSDREAMPYTEATILEVMRMGSIAPLSLPH

ATTVDTTLSKL*

>estExt_gwp.C_1010048|Brafl1

60% to estExt_fgenesh2_pg.C_610015|Brafl1

MPVFGGQFYLTFVELGKKYGDVFSLKLGMRDVVVLNSLDVIREALVKKGADFAGRTQTATGDLISEGGKDIVMGDFNPTW

KLQRKLFHGAVRAYATGRTLEDKVQGALNDVIDEFSSLEGKAVDVEAHVFKLVLNVVCSATFGHRYKMEDEDFQFLMRMS

QKFFELGAQGMLADIYPSLAFLPTPSESSFMKLSAARENLSHPQVLCGKNNLRDITDHFIKLQKEAEEEGDADINSLTDT

HIRQTIVDIFGAALDTTVQSMRWSIVLLAAHPEVQEKLAAELDSVVERNRQPSLADRSALPYMDSTINEVLRFGIVVPLS

VPHATTVDTTLMGYEIPKGTWIMPNLWNAVRDPEIWGDPNVFRPERFLDDDGKVLPKPSALMPFSAGRRACPGEPMARAD

IFLLLAGLVQKFKFSLPEGEGPPDLAPDPKGAGLFCIACPYKVVMTHRK*

 

$$$$$$$

 

>fgenesh2_pg.scaffold_180000082|Brafl1 38% to CYP2U1

95% to fgenesh2_pg.scaffold_180000046|Brafl1

MSFLTDTFPALGSLQVILLAVLCVIATLVLCGRPRNLPPGPRGLPIVGDAISLIKGGPLFVFADWSKQYGDVLTYYFGSK

RIIVLNGYATIHEALVQNAEDFSSRPPELDFLSPDNNSLGIAGEPYGPKWKEHRKFALMGLRDFGVGKRSLEGKILEESR

ALGEEISKTGERPFCISQMMQNTVANVICSMVFGCRYEYDDMAFKCLLTAINRVLSRSLDDFFAKVFPPWKLLPGVRKSY

QDVMEHKVILTDHIEEKLREHEETFDPNDIRDFMDAFLLESKKRQADANSIFTKQDHITVVFQLFLAGTDTTATTLRWAL

LYMILHPDIQEKVQQEIDSVLGLKQEPAMAHRSQMPYSEATLTEVTRLAPVAPLALYHATSNDTVFRGFSIPKGTAFIAN

IWSVHHDPNLWPEPDKFDPKRFINDEXXXXXXXXXXXXXXGRRVCLGEQLARMELFLIFTSLLQRFTFKLPEGAPKPSKK

GIHQGIYQPVPFMLKAVARK*

>fgenesh2_pg.scaffold_180000046|Brafl1 40% to CYP2U1

95% to fgenesh2_pg.scaffold_180000082

MGFDVEGAEAALSNSTFFGGPLFVFADWAKQYGDVFTYYFGSKRIIVLNGYATIHEALVQNAEDFSSRPPELDFLSPDNN

SLGIAGEPYGPKWKEHRKFALMSLRDFGVGKRSLEGKILEESRALGEEISKTGERPFCISQMMQNTVANVICSMVFGCRY

EYDDMTFKCLLTAINRVLSRSLAVFFAKVFPPWKLLPGVRKSYQDVMKHKVMLTDHIEEKLREHEETFDPNDIRDFMDAF

LLESKKRQADANSIFTKQDHITIVYQLFLAGTDTTATTLRWALLYMILHPDIQEKVQQEIDSMLGPNQEPAMAHRSQMPY

TEATLTEVTRLAPVAPLALYHATSNDTVFRGFSIPK

KAQGRPLAV*

>fgenesh2_pm.scaffold_362000002|Brafl1

71% to fgenesh2_pg.scaffold_180000082

MSFWGYMIPSFGSLQVILLAVLCVIATLVLCGRPRNLPPGPRGLPIVGNALSIMKDSSAYAKLSKKYGDVFTVYFGPRRV

VVLNGYAAIHEALVKNAENFSSRPLGQAFFSADGKTLGIADESYGPKWKEHRKFAMMSLRDFGVGKKSLEGKILEEARAL

GDEICKTNGRPFCISQMMQNAVSNVICSIVFGSRYEYDDMVFKSLLKAIQRVFGRKMVEFLAEQLPPLKVLPGVRKNYQD

LMQSQAKIMDHIKERIREHEDTFDPNDIRDFIDAFLLESNKRQTDENNTFTEQELATIVYQLFLAGTDTTATTLRWALLY

MILHPDIQEKVQQEIDSVLGPNQEPAMAHRSQMPYTEATLTEVSRHATVAPHTIQHATSNDTTFRGYNIPKGTVVEVILW

SVHHDPNLWPEPDKFDPNRFIDDAGKYVKREGVIPFSLGRRVCLGEQLARMELFLIFTSLLQRFTFKLPEGAPKPSEKGV

PGPLHQPVPFMLIAEPRE*

>fgenesh2_pg.scaffold_29000156|Brafl1 35% to CYP2X6

77% to fgenesh2_pm.scaffold_362000002|Brafl1

MSIWSYMYPAFGSLQVILLAVLCVIATLVLCGRPRNLPPGPRGLPIVGNAISLLKGALPLVYTDWSKKYGDVFTVYFGPR

LTIVLNGYAAIHEALVKNAENFSSRSPSHAMRTPDGKTLGIAAEPYGPKLKEH

>fgenesh2_pg.scaffold_263000031|Brafl1 44% to CYP2J2

89% to fgenesh2_pm.scaffold_362000002|Brafl1

MTSRSVCHRYTCTVWAAEKYATGNERTADCGKCLEHNEGIAKEPYGAKWKEHRKFAIISLRDFGVGKRSMEGKILEETRA

LDLMQSQAKLMDHIKERIREHEETFDPKDIRDFIDAYLLESKKRQADENNTFDKQELATIVYQLFLAGTYTTATTLRWAL

LYMILHPDIQLQRKYSRR*

>fgenesh2_pg.scaffold_180000048|Brafl1 39% to CYP2F1

80% to fgenesh2_pm.scaffold_362000002|Brafl1

MSYWGYMFQVFSSLQVILLAVLCVIVTLVLCGRPRNLPPGPRGLPIVGNAINLIKLTHVRAYAKWSKQHGDVFTYYFGPR

RVIVLNGYAAIHEALVRNAKDFSSRPLGEAFFSPDGKTLGIAEEPYGPKWKEYRKFAMMSLRDF*

>fgenesh2_pg.scaffold_180000081|Brafl1 39% to CYP2U1

72% to fgenesh2_pm.scaffold_362000002|Brafl1

MMSLRDFGVGKRSLEGKILQEARALGEEISKTGGRPFFIAKMMQNAVSNVICSIVFGRRYEYDDMAFKSLLKAINRVFSK

GLSEYLAHFFPALGILPFVREKEIQQAQDKIMNHIKEMIMEHEETFDPNDIRDFIDAFLLESKRRQVDEDSSFTQQEHAA

IVYQLFLAGTDTTSTTLRWALLYMILHPDIQEKVQQEIDSMLGPNQEPAMAHRSKGTAIEVNIWSVHHDPQMWPEPDKFD

PGRFINEEGKYVKREGVIPFSIGRRVCPGEQLANMEIFLIFTSLLQRFSFKLPEGAPEPSVTGRFATIHQPDPFMLIAEVRG*

>fgenesh2_pg.scaffold_676000017|Brafl1

71% to fgenesh2_pg.scaffold_180000082

MPFLSYIYVFPTLGSLQVALLAALCVIATLLLCGRPRNLPPGPRGLPIVGNALSLIKGNRLLLYADWTKKYGDVFTVHYG

SRRTVLLNSYAAIHEALVKNAEIFSSRPLGSGPSLLNPEENILGIVSATYGPTWKKHRKFAMMSLRDFGLGKKSLEGKIL

EEARVLGDEICKQDGGAFNISQMMQNAVSNVICSIVFGCRYCYDDDTFKELLMAIQRIFSAKLLESFAFVFRETIREHEE

TFDPNDIRDFIDAFLLESKKRETDDNPTFAEQQLATIVYQLFLAGTDTTSTTLRWALLYMILHPDIQEKVQQEIDSVLGP

NQEPEMAHRSQMPYTEATLAEVLRLAPVVPLGLFHSTNNDTTFRGYNIPKNTSVLVNIWSVHHDPKLWPEPDKFDPTRFL

DHTGIYVKRAEVITFSLGRRVCLGEQLARMELFLIFTSLLQRFTFKLPGGVAKTSTEGIHGAVYQPVPFMMTAEPRE*

>e_gw.29.8.1|Brafl1

72% to fgenesh2_pg.scaffold_180000082

AKLSKKYGDVFTMYFGPRRVVVLHGYAAIHEALVKNAENFSSRPLGQAFFSPDGKNLGIAEEPYGPKWKEHRKFAMMSLR

DFGVGKRSLEGKILEEARALGDEICKTNGRPFCISQMMQNAVSNVICSIVFGSRYEYDDMVFKSLLKAIQRVFGRKMVDF

LAEQLPPLKVLPGVRKDYQDLMQSQAKIMDHIKERIREHEDTFDTNDIRDLIDAFLLESKKRQTYENNTFTEQELATIVY

QLFLAGTDTTATTLRWALLYMILHPDIQEKVQQEIDSVLGPNQEPAMAHRNQMPYTEATLTEVSRHATVAPHTIPHATSN

DTTFRGYDIPKGTVLEVILWSVHHDPNLWPEPDKFDPNRFINDAGKYVKREGVIPFSLGRRVCLGEQLARMELFLIFTSL

LQRFTFKLPEGAPKPSENGIPGPLHQPVPFMLIAEPRE*

>fgenesh2_pg.scaffold_399000020|Brafl1 top part not P450 seq

63% to fgenesh2_pg.scaffold_180000082

MKTTDLREGFNVVVTEMSADWRELGHRLGLTHDYIEATDQKHQGKTPQCCREVLEQWRKESGSQATLKMLEEVLRKARHV

RVADMIKCIGDDSESPIAIEVVKTTESWIKIKWAPPTICMIGTLIGYIVEHSFFQTDEWVKAHDQGCLPSSTTEFKVGGL

TKNGQYHFRVKAVYRGRKLSEPSYSGLGIAKIQGQPLQPRNLRVTDLDTKGGIVMLEWLEPEEVNDGDFPITSYIVEKRL

HSDWVLCLKTSKLQCTIKGITDVEDWRFRVSAKNKKGLQSDPSEMVNPEVRIKVDVHNAGQANREAVKKALWKSAFEPHG

LSGKKIEEGSIVFVYSCRDPIGLCNLWMMYCRGEVCQYFQKLLVTENVLRTCSTTDVKLVVTIDPEDFRASGNHLLLTRE

TKHGYRVLSKSLNTDLFCLINNLASFKGKTTMLTQENSIADKIAGTSNTNSALPGTGDERNQTVCEDLNEAGASNSVPVD

NESSSIDGATMAARPTPTSAQLHSAFDTICYWMKDH

37% to CYP2U1

PALVYTEWS

KKYGDVFTAYFGPTRTVVLNGYAAIHEALVKNAEV

FSSRPPAVASFSPDGKTLGIIQEPYGPKWKEHRKFTVMSLRDFGVGKRSQEGKILEEARALGDEIRKTESHAFCISQMMQ

KAVSNIVFSVLFGCRYEYDDKTFEGLLQAINGIQSRDFAVVLAQFFPPAKVLPGIRKPYKQLKQNVTILKDYIKEKIKEH

ENSFDPGDIRDFVDAFLLESERQKGNKKSIFNEQEHAVIVYQLLLGGSDATSLSWALLYMILHPDIQEKVQQEIDSVLGP

NQEPSMTHRSQ

>fgenesh2_pg.scaffold_362000018|Brafl1 43% to CYP2U1

73% to fgenesh2_pg.scaffold_399000020|Brafl1

76% to fgenesh2_pm.scaffold_362000001|Brafl1

67% to fgenesh2_pg.scaffold_180000082

MNCSLLLPWNNARGVFKFADPPALVYTDWA

KKYGDVFTAYFGPTRTVVLNGYATIHEALVKNAEDFSSRPTAQASFTPDG

KTLGIAQEVYGPKLKEHRKFAVMNLRDFGLGKKSLEGKILEESRALCDEISKIDGRPFCISQMMQNAVSNVICSVLFGRR

YEYDDMAFKSLLQSMRGILTRDFAVVLAQFFSPVKVLPGVRKPYQQLRKNMKKLEEHIKEKIKEHEETLDSDNIRDFIDA

FILESKKRQGHGNSIFTEQEHTVIVYQMFLAGTDTTTNTLHWALLYMILHPDIQEKVQQEIDSVLGPNQKPEMVHRSQMP

YTEATLAEVTRISPVTPITIPHGTSNDTVFRGYNIPKDTVVTVNIWSVHHDPKLWPEPDKFDPTRFIDDEGKYVKKIEII

PFSIGRRICPGEQLARMELFLFFTSLLQRFTFKLPEGAPPPFQQRDARTNI*

>fgenesh2_pm.scaffold_362000001|Brafl1 41% to CYP2U1

71% to fgenesh2_pg.scaffold_399000020|Brafl1

76% to fgenesh2_pg.scaffold_362000018|Brafl1

69% to fgenesh2_pg.scaffold_180000082

MADFPRSRPRGLPIVGNAISLI

KKYGDVFTVYFGPSRTVVLNGYAAIHEALVKNAENFSSRSPNQAMRTPDGKTHGIAAE

PYGPKLKEHRKFAMMSLRDFGVGKRSLEGKILEEARGLGDEICKTESRAFCISQMMQNAVSNVICSIVFGRRYEYDDTAF

KDLLKAINGVFSRSFAVIFAQVVRPMRILPGVRKPFQELKRNQAKLINHIRDRIKEHEDTFDPNDIRDFIDAFLLESKKR

QGDENSTFTDQEHAAIVYQLFLGGTDTTAITLRLALLYMILHPDIQEKVQQEIDSVLGPNQEPAMAHRSQMPFTEATLAE

VSRLATVTPMTIPHATSNDTAFRGYNIPKNTSVTVNIWSVHHDPNLWPEPDKFDPTRFINDEGKYFKKNEVIAFSMGRRV

CLGEQLARMELFLFFTSLLQRFTFKLPEGAPKPSEKGIHAALHHPVPFKLIAEPRE*

>e_gw.29.92.1|Brafl1 43% to CYP2U1

94% to fgenesh2_pm.scaffold_362000001|Brafl1

PFCISQMMQNAVSNVICSIVFGRRYEYDDMAFKDLLNAINGVFSRSFAVIFAQVFRPMRILPGVRKPFQKLKRNQAKLIN

HIRDRIKEHEDTFDPKDIRDFIDAFLLESKKRQGDENSTFTEQEHAAIVYQLFVAGTDTTSTTLRWALLYMILHPDIQEK

VQQEIDSVLGPNQEPAMAHRSQMPFTEATLAEVSRLASVTPMTIPHGTSNDTAFRGYNIPKNTSVTVNIWSVHHDPNLWP

EPDKFDPTRFLNDEGKYVKRNEVLAFSIGRRVCLGEQLARMELFLFFTSLLQRFTFKLPEGAPKPSEKGIHAALHHPVPF

KLIAEPRD*

>e_gw.263.24.1|Brafl1 43% to CYP2U1

95% to e_gw.29.92.1|Brafl1

FCISQMMQNAVSNVICSIVFGRRYQYDDMAFKDLLNAINGVFSRSFAVIFAQVFRPMRILPGVRKPFQELKRNEAKLINH

IKDRIKEHEDTFDPKDIRDFIDAFLLESKKRQGDENSTFTKQEHAAIVYQLFLAGTDTTAITLRWALLYMILHPDIQEKV

QQEIDSVLGQNQEPSMAHRSQMPFTEATLAEVSRLASVTPMTIPHGTSNDTAFRGYNIPKNTSVTVNIWSVHHDPNLWPE

PDKFDPTRFLNDEGKYVKRNEVLAFSIGKITLFFLVVVL*

>fgenesh2_pm.scaffold_399000002|Brafl1 52% to CYP2U1

78% to e_gw.29.92.1|Brafl1

MPYTEATLTEVSRVAPVSPLTVPHGTSNDTVFRGYNIPKDTVVTVNVWSVHHDPNLWPEPEKFDPSRFIDDDGKYVKRNE

IISFSIGRRVCPGEQLARMELFLIFTSLLQCFTFKLPDGAPKPSEKGMRGPIYKPVPFMLIAEPRD*

>e_gw.44.5.1|Brafl1 40% to CYP2U1

69% to fgenesh2_pg.scaffold_180000082

RLLLFAEWSKKYGDVFTVHYGPRRTVLLNSYAAIHEALVKNAEIFSSRPVNSSQTVLNPEENILGIIAEPYGPTWKKHRK

FAMMSLRDFGLGKRSLEGTILEEARALGDEICQQDGGAFCISQMMQNAVSNVICSIVFGCRYEYDDKTFKELLKAMQRVV

SAKLVEQLALWYRPVSILPGVRQPCQELKNSLAKLMDHIKERIQEHEETFNPNDIRDFIDAFLLESKQQETDDSPTFAEQ

QHATIVYQLFLAGTDTTSTTLRWALLYMILHPDIQEKVQQEIDSVLGPNQEPSMAHRSQMPYTEATLAEVLRLAPVVPLS

VIHSTSNDTTFRSYNIPKNTSVLVNIWSVHHDPKLWPEPDKFDPTRFLDDAGKYVKRAEVITFSLGRRVCLGEQLARMEL

FLIFTALLQRFSFKLPEGVTKPSEEGIHGAVYQPVPFMMTAEPRE*

>gw.81.152.1|Brafl1 41% to CYP2U1

75% to e_gw.44.5.1|Brafl1

TKQYGDVFTVYYGSMRMVLLNSYAAVHEALVKNAEIFSSRPTIQTILNPDKNILGKKSDVHTLRASFLHHPYGPTWKKHR

KFAMTSLRDFGLGKKSSEGRILEEARTLGDEICKKDGGAFCISQMMQNAVSNIICSIVFDCRYEYDDSTFKDLLN

 

$$$$$$$$$

 

>fgenesh2_pg.scaffold_561000016|Brafl1 38% to CYP2U1

MAQAFKIPESFPFTSMDLSTLLVFIVTFVLAVRFFKVKGHVQGNLPPLVPGGWPLVHHMPAFFTKNLPLQLHKWAKEFGD

VYRVKWFMNKEVHVVSGYTAIKEMLEKDEFCTRRDRYVEIAVGGDQDILMAPYGEVFKKRRRFATSVFRRLGVKMGQGSI

EDQIQEEARFICVKISGYSKQPFDASSDLTTAAGNIICALVFGKRFDYGDTRFQHLQTTMKKLGEEMARWQIPFITFIPY

VQDPAAGLRFYSKKLQQFIREEIDRHRLNLDPENPRDFIDYCLLQLAQQDGNEEWMNDDNVVYILQDLFVAGTDTTAATL

TWALLYMILYPDVQQKVQAELDSVLGASKPSLAHRDQLPFTAATIMESQRIRHIAGLMFIRDTAESTRLRGFDIRKGKKL

VPNLRSVHMDPEVWPNPDDFDPSRFLDVDGKVVKNPPSFLPFSAGRRNCLGEQLAKMELFLLFSTILQHFTLKVPEGAPT

PSTEGINKSLSMGPVPFQLCAVSR*

>fgenesh2_pg.scaffold_129000022|Brafl1

98% to fgenesh2_pg.scaffold_561000016|Brafl1

MAQAFKIPESFPFTSMDLSTLLVFIVTFVLAVRFFKVKGHVQGNLPPLVPGGWPLVHHMPAFFTKNLPLQLHKWAKEFGD

VYRVKWFMNKEVHVVSGYTAIKEMLEKDEFCTRRDRYVEIAVGGDQDILMAPYGEVFKKRRRFATSVFRRLGVKMGQGSI

EYQIQEEARFICVKISGYSEQPFDVSSDLTTAAGNIICALVFGKRFDYGDTRFQHLQTTMKKLGEEMARWQIPFITFIPY

VQDPAAGLRFYSKKLQLFIREEIDRHRLNLDPENPRDFIDYCLLQLAQQDGNEIWMNDDNVVYILQDLFVAGTDTTAATL

TWALLYMILYPDVQQKVQAELDSVLGATKPNLAHRDQLPFTAATIMESQRIRHIAGLMFIRDTAESTRLRGFDIRKGKKL

VPNLRSVHMDPEVWPNPDEFDPSRFLDAEGKVVKNPPSFLPFSAGRRNCLGEQLAKMELFLLFSTILQHFTLKVPEGAPT

PSTEGINKSLSMGPVPFQLCAVSR*

>fgenesh2_pg.scaffold_222000070|Brafl1

76% to fgenesh2_pg.scaffold_561000016|Brafl1

MAQVFMLPHRFPFTILDVSTLLVFIVTFLLAVRLLRKGQMPGNLPPSVPGGWPLLHHLPTLFRADVRLQLDKWARGLGDV

YHVKIFWDEMYVVSGYDALKEMMEAEVFSTRFDACTSAITGDGQDIIMAPYGEIFKKRRRFATSVFRQLGVKMGRGSIQD

QIQEEARSICVRISGYREQPFDVSADLATAAGNITCALVFGKRFDYGDTRFQHLQTTMKNLGAEMAKWKVPFITYFPIVQ

DAAAGQKFYSKKVQQFIREEIDRHRLNLNPEDPRDFIDYCLLQLAQQDGSGTWLKEDNVVYIIQDLFLAGMDTTAATLTW

ALLYMILYPDIQQKVQSELDSVLGATKPSLAHRDQLPFTTATIMETQRIRHISPVLFGRWAAESTRFRGFDIAKGTYLAP

NLRSVHMDPEAWPDPEIFDPNRFLDVESKVVKNPPSFLPFSTGRRSCLGEQLAKMELFLLFSAILQHFTLKVPEGAPTPS

TEGIFKSLSMVPAPFQLCAVSR*

>estExt_fgenesh2_pm.C_1140001|Brafl1

74% to fgenesh2_pg.scaffold_561000016|Brafl1

MAQVYTLLEPFPFTILDVSTLLVFLVTFGLAVRFLRGKRPENLPPLVPGGWPLVHHLPTLFKKDFRLQVDQWAREFGEIY

RVNIFGKEIYVVSGYTALKETMEKDEISTRTDPKLGATLGGHDILMAPYGEVFKERRRFAASVFRRLGVKMGRGSIQDQI

QEEATSICGKICGYNKKPFDISSDLTTATGNVICALVFGKRFDYGDTRFQHLLTTMENLGAEVARWEFPFITYIPGLQDP

IAGTRFYSKKLQQFIREEVDQHRLKLDPENPRDFIDYCLLQLAQQDGEGTWLKEENVVYIIQSLFMAGTDTTAATLTWAL

LYMVLYPDAQQKVQAELDSVLGATKPSLAHRDQLPYTTATIMEVERIRHIGPILFGRLATGTTRLRGYDIAEETFLLLNL

RSVHMDPAAWPNPDVFDPSRFLDADGKVVNNPDSFLPFAAGRRNCLGEQLAKMELFLLFSTILQHFALKLPVGAPTPSTT

GIFKSLSMGPAPFKLCAVSR*

>e_gw.943.6.1|Brafl1

76% to fgenesh2_pg.scaffold_561000016|Brafl1

MSTLLVFIVTFFLAVRFLIKVKRPGNRPPSAPGGWPLLNHAPQLFKQGLHLQLDMWAKELGDVYSFKAMSDEYYAVSGYT

AIKELVENDVFSTRTDGSISPAVGGDQDIILAPYGVFKERRRFATSVLRRLGMKMGRGSIQDQIQEEASYICAKISGYSE

QAFDISADVTTATGNIICTLVFGKRFDYGDTGFQHLQTTMKGLGAEMVKWHLPFFTFIPIDPNAGVLFHAKNLQQFIQEE

IDRHRLNLDPEHPRDFIDYCLLQLAQQDGSGIWMNKDNVVYILQDLFIAGTDTTAATLTWALLYMILYPDVQQKVQAELD

SVLGATKPSLAHRDQLPFTIATIMEAQRIRHIGPVLFVRRAAKPTRFRGYDIAEGAAMVPNLRSVHMDPAVWPNPDLFDP

SRFLDADGKVVNNPPSFLPFSTGRRNCLGEKLAKMELFLLFSTILQHFTLKLPEGAPTPSTEGTFKSLSMGPAPFQVCAV

PR*

>fgenesh2_pg.scaffold_222000071|Brafl1

82% to fgenesh2_pg.scaffold_561000016|Brafl1

MAPYGEIFKKRRRFATSVFRQLGVKMGRGSIQDQIQEEACSICVRISGYREQPFDVSADLATAAGNITCALVFGKRFDYG

DTRFQHLQTTMKNLGAEMAKWKVPFITYFPIVQDAAAGQKFYSKKVQQFIREEIDRHRLNLNPEDPRDFIDYCLLQLAQQ

DGSGTWLKEDNVVYIIQDLFLAGMDTTAATLTWALLYMILYPDIQQKVQSELDSVLGATKPSLAHRDQLPFTTATIMETQ

RIRHISPVLFGRWAAESTRLRGFDIAKGTYLAPNLRSVHMDPEAWPDPEIFDPNRFLDVESKVVKNPPSFLPFSTGRRSC

LGEQLAKMELFLLFSAILQHFTLKVPEGAPTPSTEGIFKSLSMVPAPFQLCAVSR*

>e_gw.80.21.1|Brafl1

81% to fgenesh2_pg.scaffold_561000016|Brafl1

ILLAPYGEVFKERRRFATSVFRRLGVKMGRGSIQDRIQEEACYIFLSLQKISGYGEQPFDVSADLTTAAGNIICALVFGK

RFDYGDTRFQHLQTTMKNLGAEMVKWIYPFVTYIPKDPFKGLRFHAKKLHQFIREEIDRHRLNLDPENPRDFIDYCLLQL

ARQDGSGTWLNEDNMVYIILDLFIAGTDTTAATLTWALLYMILYPDVQQKVQAELDSVLGATKPSLAHRDQLPFTTATIM

EAQRIRHVVPLMFGRKAAKLTSLRGFDIAEGTFLIPNLRSVHMDPAAWPDPEVFDPSRFLDGDGKVVNNPPSFLPFSTGR

RNCLGEQLAKMELFLLFSTILQHFALKLPEGAPTPSTEGTFKSLSMGPAPFQLCAVPR*

>e_gw.110.19.1|Brafl1

80% to fgenesh2_pg.scaffold_561000016|Brafl1

ILLAPYGEVFKERRRFATSVFRRLGVKMGRGSIQDRIQEEACYIFLSLQKISGYGEQPFDVSADLTTAAGNIICALVFGK

RFDHGDTRFQHLQTTMKNLGAEMVKWIYPFVTYIPKDPFKGLRFHAKKLHQFIREEIDQHRLNLDPDDPRDFIDYCLLQL

ARQDGEGTWLNEDNMVYIIQDLFIAGTDTTAATLTWALLYMILYPDVQQKVQAELDSVLGATKPSLAHRDQLPFTTATIM

EAQRIRHVAPLMFGRKAAKSTSLRGFDIAEGTFLIPNLRSVHMDPAAWPDPEVFDPSRFLDGDGKVVNNPPSFLPFSTGR

RNCLGEQLAKMELFLLFSSILQHFALKLPEGAPIPSTEGTFKSLSMGPAPFQLCAVPR*

>fgenesh2_pg.scaffold_122000050|Brafl1

72% to fgenesh2_pg.scaffold_561000016|Brafl1

MEIVKAVTRFSAPGTVPHAFPSVLHLELKVRVGTVCNSAGGRITPSNIISDDNPSRKCDRDYHTNMMTLPVRFPFTTLDM

STLLVFIVTFFLAVRFLIKVKRPGNRPPSAPGGWPLLNHAPQLFKQGLHLQLDMWAKELGDVYSFKAMSDEYYAVSGYTA

IKELVENDVFSTRTDGSISPAVGGDQDIILAPYGVFKERRRFATSVLRRLGMKMGRGSIQDQIQEEASYICAKISGYNEQ

AFDISADVTTATGNIICALVFGKRFDYGDTGFQHLQTTMKGLGAEMVKWHLPFFTFIPIVQDPNAGVLFHAKNLQQFIQE

EIDRHRLNLDPEHPRDFIDYCLLQLAQQDGSGIWMNKDNVVYIIQDLFMAGTDTTAATLTWALLYMILYPDIQQKVQAEL

DSVLGATKPSLAHRDQLPFTIATIMEAQRIRHIGPVLFVRRAAKPTRFRGYDIAEGAAVTLIFLILNFNLYSYRHVSRTA

E*

>estExt_fgenesh2_pg.C_1140004|Brafl1

71% to fgenesh2_pg.scaffold_561000016|Brafl1

MAQVYTLLEPFPFTILDVSTLLVFLVTFGLAVRFLRGKRPENLPPLVPGGWPLVHHLPTLFKKDFRLQVDQWAREFGEIY

RVNIFGKEIYVVSGYTALKETMEKDEISTRTDPKLGATLGGHDIVMAPYGEVFKERRRFAASVFRRLGVKMGRGSIQDQI

QEEASSICGKICGYNKKPFDISSDLTTATGNVICALVFGKRLDYGDTRFQHLLTTMENLGAEVARWEFPFITYIPGLQDP

IAGTRFYSKKLQQFIREEVDQHRLNLDPENPRDFIDYCLLQLAQQDGEGTWLKEENVVYIIQSLFMAGTDTTAATLSWAL

LYMVLYPDAQQKVQAELDSVLGATKPSLAHRDQLPYTTATIMEVERIRHIGPILFGRLATGPTSLRGYDIAEETFVIFVL

QLHNL*

>fgenesh2_pg.scaffold_41000075|Brafl1

73% to fgenesh2_pg.scaffold_561000016|Brafl1

MAQVFTLPEGFPFTILDVSTLLVFLFTFVLAVRFLRGKRSGNLPPLVPGGWPLVHHLPTLISKDFRAQVDQWAREFGEVY

RVKFLGKEIYVVSGYPTLKKMMEKDEFSTRSDPKLGPTLGGQGNIICALVFGKRYDYGDTRFQHLLTTMANLGVEVARWE

FPFITYIPGLQDPIAGTRFHSKKLQQFIREEIDLHRLNLDPEDPRDFIDYCLLQLDQQDGEGTWLKEENVVFIIQSLFMA

GTDTTAATLTWAMLYMVLYPDVQAELDSVLGATKPSLAHRDQLPYTTATIMEVERIRHIGPVLFARQSTGPTRLRGYDIA

EGTLVIVVLIYRRY*

 

$$$$$$$$

 

>estExt_GenewiseH_1.C_4770047|Brafl1 39% to CYP2U1

MSILLEVVTTARHFADLPTFLAATCVCLLTYLYLQRPRNLPPGPRGWPLLGNIPTLAKSAFLPATFTELSKQYGDVMTIW

IGGTIAIVLSGYETIRTALVKRAEDLSSRKIPASVADLRGDGTTKSSVKGILYAAYGPQWKHQRKFALMTLRDFGFGKRS

LEGKVNEEANALVQEVLSQNGQPFDPKIIIQNAVSNVICSIAFGERFEYGDPDFLRLIQLLNATVEENASLVDKIGMIIP

VFRYLKGNSSQERMVKMFQGLQEFCREQIEKHRLTFDPNDIRDFIDAFLLEQQRAPEEKAREHFTDKELQEVLIDLFLGG

TETTATTTRWGLLYMMLNPDIQEKVHQEIDSVLGQSAPSYAQRNQLPYTTATLAEVQRMKPVAPLSVPHAASRDTALNGY

NIPQDAMIFVNLWSVHMDPQLFPDPNTFRPERFLDQDGNFVKHEAVIPFGIGPRVCLGEQLAKMEVFMLFVSLMQRFTFH

LPEGAPEPSMLGKLASAINVPCPFELCAVAR*

>e_gw.106.100.1|Brafl1 52% to CYP2U1

82% to estExt_GenewiseH_1.C_4770047|Brafl1

RMKPVAPLSVGHAPSKETTLNGYNIPQEAIILANLWSVHMDPKLFPEPNTFRPERFLDQDGNFVKHEALVPFSMGPRTCL

GEQLAKMELFLLFVSLMQRFTFHLPEGAPKPSTLGAY

>fgenesh2_pg.scaffold_90000026|Brafl1 30% to CYP2P6

68% to estExt_GenewiseH_1.C_4770047|Brafl1

MASLSEVVTMVRDYVDVPTILVAACACLLTFLYLQRPKNLPPGPWGWPLLGNIPMLAKCAFVPATFTELSKQYGDVMTVW

IGRDVNIIISGYKTIRNALVKRADEFSSRRIFPAVADLRGPGDTSTSTKGDLFCATYNLHLASLRG F*

>estExt_gwp.C_4770042|Brafl1

86% to estExt_GenewiseH_1.C_4770047|Brafl1

MSILLEVVTTARHYGDLPTFLAAACVCLLTYLYLQRPRNLPPGPRGWPLLGNIPMLAKTAFLPATFTELSKQYGDVMSIR

LGGNLAIVLSGYETIRTTLVKRAEDFSSRRVPPVVADIRGDETTKRTAKGVLFAAYGPQWKHQRKFALMTLRDFGVGKRS

LEGKVTEETDALVQEILSQNGQPFDLKIMMQNAVSNIICSIAFGGRFEYGDPDFLRLIELLNATIEEKPSVTDRLGAIHP

VFRYLGTFGKDSRQGRLLKMFQALQEFCREQMEKHRLTFDPNDIRDFIDAFLLEKQRAPEEKAREHFTDKELQEVLIDLF

LAGTETTATTTRWALLYMMLNPDIQEKVHQEIDSVLGQSAPSYAQRNQLPYTAATLAEVQRMKPVAPLSIPHAASRDTTL

NGYNIPQDAMIFINLWSVHMDPQLFPETNTFRPERFLDQDGNFVKHEALVPFGIGHRVCLGEQLAKMELFMLFVSLMQRF

TFNLPEGAPEPSMLGKLGSAINVPFPFELCAVAR*

>fgenesh2_pg.scaffold_41000091|Brafl1 41% to CYP2U1

74% to estExt_gwp.C_4770042|Brafl1

MSHSGKVPIHIKQSLSTFVFQEGRHDNFDLSSDYVYLEMNILLEILRAGRQYADLPTLLVACVCLLTYLYIRGPRNLPPG

PWGWPLLGNGPMLAKLSKQYGDVMTIWIGRVPAIVLTGYETIRTALVKRAEDFSSRKTHSPIAKIRGDGITADGMLNTAI

TNKPTVGDLLCMIHPVFRYIQPSGASLIKTSGKLYEALREFCRERVEKHRLTFDPNNIRDFIDAFLLEQQQRDPDVRARE

KFSDRQLHEVLIDLFIAGTDTTGATSHWALLYMMLNPDIQEKVHQEIDSVLGQSTPSYAQRNLLPYTTATLAEVQRMKPV

APLSVGHAPSRETTLNGYNIPQEAIIMANLWSVHMDPKLFPEPNTFQPERFLDQDGNFVKHEALVPFSMGAWNIFNDFRY

VADELDSTHVGPNTVIVLSLWAHYTAEPLDMIRSRLYAIRCAIHRLMRRSPGTRVLVRTGTTREHTGGELQYYLLGSDWL

AYQITEVIREMFVADSDVFVLDTWDMSVCQPGKDFIHPDQTMVDNQLNILFSHICPN*

>estExt_fgenesh2_pg.C_750139|Brafl1 39% to CYP2P10, 405 to CYP2U1

78% to estExt_GenewiseH_1.C_4770047|Brafl1

MSILLEVVTVSRHFGDLKTFLAATCVCLLTYLYLQRPRNLPPGPRGWPLLGNIPMVAKSAFLPATLAELSKQYGDVMTIW

MGLAPAIVLSGYETIRTALVKRAEDFSSRKIPPVATMAGRDKGVLLAPYGPHWKHQRKFALMTLRDFGFGKRSLEGKITE

ETNALVQEILSYNGQPFDLKIMMQNAVSNIICSIVFGSRFEYGDPDFLRLIRLLNSVVEAKPSAIDRLEMIHPVFRCLRF

IGPSKNGKVMRMIQTLQGFCREQIQKHRLTFDPNDIRDFVDAFLLEQQRAPEEQAREHFTDKQLQEVLMDLFVAGTETTA

TTTRWALLYMMLNPEIQEKVHQEIDSVLGQSAPSYAQRHLLPYTTATLAEVQRINSIVPLVVRGASRDTTFNGYNIPQEG

RILVNLWSVHMDPQLFPEPNTFQPERFLDKSGNFVKHEALIPFSMGHRICLGEQLAKMELFMLFVSLMQHFTFNLPEGAP

EPSMVGKFGGVVNVPFPFELCAVARG*

>fgenesh2_pm.scaffold_497000001|Brafl1

75% to estExt_GenewiseH_1.C_4770047|Brafl1

MTASRHLADLPTLLAATCVCLLAYLYLRRPRNLPPGPKGWPIVGNLPMLANSAFLPATLMELSKQYGDVMTIWMGRFPAI

VLTGHETIRNALVKRAEDFSSRKAPPAQAMAGRDKGVLQAPYGPHWKQQRKFALMTLRDFGFGKRSLEVKISEEADALVQ

EILSHNGQPFDLKIMMQNAVSNIICSIVFGDRFEYGDPDFLRLISLLNTVIEAKPSVIDRLENIHPVFRFLRLFGKSGRD

KATRMLQTVQEFCREQIEKHRLTLDPNDIRDFTDAFLLEQQRAPEEKAREHFTDKQLQEVLMDLFVAGTETTATTTRWAL

LYMMLNPNIQEKASSGNFYMCPQVHQEIDSVLGQSAPSYAQRNLLPYTTATLAEVQRIKSIVPLVGHAASRDTTFNGYNV

PQEGRLLINLWSVHMDPQLFPEPNTFQPERFLDQDGNFVKHEALIPFSMGHRICLGEQLAKMELFMLFVSLMQRFTFNLP

EGAPVPSMLGKLGSVVNVPFPFELCAVARG*

>fgenesh2_pm.scaffold_234000005|Brafl1 35% to CYP2U1

68% to fgenesh2_pm.scaffold_497000001|Brafl1

MTASCHYVDLPTFILAAFVGLLTYLYLQRPRNLPPGPRGWPLFGNILMLAKSEFLPATLTELSKQYGDVMTIWTGRFPAI

VLSGYETIRTALVKRATEDFSSRGFLMAPCGPRWKQHRKFALMTLRDFGVGKRSLEGKINEEAEALAQEVLSQNGQPFDL

QIMMENCVCNIICSIVFGDRFEYGDPEFLRLIHSLNTTIEAKPTAIDTLEVILPVFRHLRLSSETIEAKAVKMFRASQEF

CGRQIVKHRLTFDPNDIRDFIDAFLLEQQRAPDERARANFNDKQLQEVHQEIDSVLGQSMPSYAKRNLLPYTAATLAEVQ

RIKPVAPLSVPHQASRDTTLNGYNIPYEGCVIVINLWSVHMDPRLFPEPNTFQPERFLDNHGNFVPRETLIPFGIGHRMC

LGEQLAKMELFMLFVSLMQRFTFKLPEGAPKPSMYGNFNAASFVNPPIPFELCAFPRE*

>e_gw.95.54.1|Brafl1

82% to estExt_GenewiseH_1.C_4770047|Brafl1

TFTELSKQYGDVMTIWTGQGPAIVLSGYETIRNALVKRAEDFSSRKLPPTMADIRGDETTKNAAKGVLHAAYGPHWKHQR

KFALMTLRDFGFGKRSLEGKVNEEGNALVQEILSHNGQPFDLKIMMQNAVSNIICSIVFGGRFEYGDPEFRRLIHLLNAV

VETKPSFMDRLGNILPVFRYLRFRGNSIQEKGTKMLVTLQEFCREQIEKHRQTFDPNDIRDFIDAFLLEQQRAPEEKARE

NFTDKELQEVLIDLFLAGTETTATTTRWALLYMMLNPDIQEKASSRQLLVHQEIDSVLGQSAPSYAQRNQLPYTAATLAE

VQRIKAIVPLSVPHAASRDTTLNGYNIPQEATIFINLWSVHMDPQLFPDPNTFQPERFLDQDGNFVKHEAVIPFGIGHRV

CLGEQLAKMELFMLFVSLMQRFTFHLPEGAPEPSMVGTYGRTINVPVPFELCAVARG*

>e_gw.377.8.1|Brafl1

77% to estExt_GenewiseH_1.C_4770047|Brafl1

ATLAELSKRYGDVMTIWMGRVPAIVLSGYETIRTALVKRAEDFSSRKIPPVATMAGRDKGVLLAPYGPHWKHQRKFALMT

LRDFGFGKRSLEGKITEETNALVQEILSYNGQPFDLKIMMQNAVSNIICSIVFGGRFEYGDPDFLRLIRLLNSVVEAKPS

AIDRLEMIHPVFRCLRLIGTSKNGKVMRMIQTLQQFCREQIEKHRLTFDPNDIRDFIDAFLLEQQRAPEEQAREHFTDKQ

LQEVLMDLFVAGTETTATTTRWALLYMMLNPDIQEKVHQEIDSVLGQSAPSYAQRDLLPYTTATLAEVQRINSIVPLVVR

GASRDTTFNGYNIPQEGRILINLWSVHMDPQLFPEPNTFQPERFLDKNGNFVKHEALIPFSMGHRICLGEQLAKMELFML

FVSLMQRFTFNLPEGAPEPSMLGKFGGVINVPFPFELCAVARC*

>fgenesh2_pm.scaffold_2000049|Brafl1 39% to CYP2J2

76% to e_gw.377.8.1|Brafl1

MTLRDFGFGKRSLEGKVTEEANALVQEVLSQNGQPFDLKIMMQNAVSNVICSIVFGDRFEYGDPDFMRLIRLLNAFVEAK

PTVHDLLTMIHPLFRHLRHIGASREGKSVKMIRALQEFCGEQIEEHRVSFDANDIRDFIDAFLLEQQRAEDEQAKEKYTD

RELQEILVDLFLAGTETTATTTRWALLYLMLNPDVHQEIDSVLGQSAPSYSQQNLLPYTAATLAEAMRMKPIVPIVVRAP

SRDTTLNGYNIPQEAGIMV*

>e_gw.654.1.1|Brafl1

75% to estExt_GenewiseH_1.C_4770047|Brafl1

MISYFDFFFQSAFLPATLMELSKQYGDVMTVWVGRFPTIVLTGHETIRNALVKRAEDFSSRKAPPAQAMAGRDKGVLQAP

YGPHWKQQRKFALMTLRDFGFGKRSLEGKISEEANALVQEILSQNGQPFDLKIMMQNAVSNIICSIVFGGRFEYGDPDFL

RLISLLNTVIEAKPSAIDRLENIHPVFRYLRLFRTSRNDKATTMLQSVQEFCREQIDKHRLTFDPNDIRDFVDAFLLEQQ

RAPEEKAREHFTDKQLQEVLMDLFVAGTETTATTTRWALLYMMLNPNIQEKVHQEIDSVLGQSAPSYAQRNLLPYTTATL

AEVQRIKAIVPLVGRAASRDSTLNGYSIPQEGRLLINLWSVHMNPQLFPEPNTFQPERFLDQDGNFAKHEALIPFSMGHR

ICLGEQLAKMELFMLFVSLMQRFTFNLPEGAPVPSMLGKLGSVVNVPFPFELCAVARG*

>e_gw.301.57.1|Brafl1

73% to estExt_GenewiseH_1.C_4770047|Brafl1

LLTYLYLQRPRNLPPGPRGWPLLGNLPMLRKSAFLPATLTELSKQYGDVMTTWNGRTPTIVLTGYETIRTALVKRAGDFS

SRRANAVLVKLRGDGITAGGILYSLDGPRLKHLRKFTLKTFRDFGVGKRTLEDKVNEEANILVQEVLSQNGQPFDIKIMM

QNAVCNIIFSIVFGDRLDYDNPDFLRLIRLLNTAIETKPTISDILTFILPVFRHLQSSEASLIAKVEKMYQALREFCSEQ

IQKHRMTFDPNDTRDFLDSFLLEQHRATDERTLETFTDKQLKEVLIDLFLAGTETTATTTRWALLYMMLNPNIQEKGTTM

CPQVHQEIDSVLGQSAPSYAQRNLLPYTTATLAEVQRFKPVAPLSVQHAAPRDTTLNGYNIPQNAPILINLWSVHMDPKL

FPEPNTFQPERFLDQDGNFVKHEALIPFSLGKGHRACLGEQLARMELFLLFVSLMQRFTFHLPEGAP

>gw.106.83.1|Brafl1 34% to CYP2P6

67% to e_gw.301.57.1|Brafl1

NLPPGPWGWPLLGNVLFLIYFQSTFLPATLMDLSKEYGDVMTVWIGRVPTIVLTGYETIRTALVKRAEDFSSRKTHSPSR

LFSGVIFAVYGQRWKQLRKFTLMTLRDFGVGKRSLEGKVNEEANALVHAILSQNGQPFDVKIMLQNTVCNIIFSIAFGDR

LEYDNPDFLRLIGMLNTAITSKPTVGDMLYMIHPVFRYIQPSGASLIETSGKLYEALREFCRERIEKHRLTFDPNNIRDF

IDAFLLEQQQ

>fgenesh2_pg.scaffold_703000009|Brafl1 35% to CYP2J2

96% to e_gw.301.57.1|Brafl1

MDTKNLLDVLTAVRHFADLPTFLVATCVCLLVYIYLQRPRNLPPGPRGWPLLGNLPMLRKSAFLPATLTELSKQYGDVMT

TWNGRTPTIVLTGYETIRTALVKRAGDFSSRRANAVLVKLRGDGITADGILYSLDGPRLKHLRKFTLKTFRDFGVGKRTL

EDKVNEEANILVQEVLSQNGQPFDIKIMMQNAVCNIIFSIVFGDRLDYDNPDFLRLISLLNTAIETKPTISDILTFILPV

FRHLQSSEASLIAKVERMYQALREFCSEQIQKHRLTFDPYDIRDFLDSFLLEQHRATDDRAVETFTDKQLKEVLIDLFLA

GTETTATTTRWALLYMMLNPNIQEKGSA*

>fgenesh2_pg.scaffold_2000358|Brafl1 45% to CYP1A1

74% to fgenesh2_pg.scaffold_703000009|Brafl1

MECLYKPGANTTPGGLEACTSFSPDDNSSRTVASRLRDSKRPRNLPPGPRGWPILGNMPMLAKSDFLPATFTELAAQYGD

VMTIWTGRAPNIVLTGYETIRAALVKRAEDFSSRKAPPAMLDVRGDGTANGTK

>estExt_fgenesh2_pm.C_750019|Brafl1

77% to estExt_GenewiseH_1.C_4770047|Brafl1

MTIWMGRVPAIVISGYETIRTALVKRAEDFSSRKILPVVAMAGRDKGVLMAPYGPHWKHQRKFALMTLRDFGFGKRSLEG

KISEECNALVQEILSYNGQPFDLKIMMQNAVSNIICSIVFGGRFEYGDPEFLRLIRLLNSVVEAKPSVIDRLETIHPVFR

YLRLIGPSKNDKMVRMIQTLQGFCREQIQKHRLTFDPNDIRDFIDAFLLEQQRAPEEQAREHFTDKQLQEVLMDLFVAGT

ETTATTTRWALLYMMLNPDIQEKASSRQLLVTVHQEIDSVLGQSAPSYAKRDLLPYTTATLAEVQRINSIVPLVVRGASR

DTTFNGYNIPQEGSFLVNLWSVHMDPQLFPEPNTFQPERFLDQDGNFVKHEALIPFSMGHRVCLGEQLAKMELFMLFVSL

MQRFTFNLPEGAPEPSMLGKLGGLINVPFPFELCAVARG*

>estExt_fgenesh2_pg.C_3770039|Brafl1

75% to estExt_GenewiseH_1.C_4770047|Brafl1

MTIWMGRVPAIVISGYETIRTALVKRAEDFSSRKIQPVAAMAGRDKGVLMAPYGSHWKHQRKFALMTLRDFGFGKRSLEG

KITEECNALVQEILSHNGQPFDLKIMMQNAVSNIICSIVFGGRFEYGDPDFLRLIRLLNSVVEAKPSFMDRLEMIHPVFR

CLRFIGTSKNDKMTRMFQTLQQFYREQIEKHRVTFDPNDIRDFIDAFLLEQQRAPEEQAWEHFTDKQLQEVLMDLFVAGT

ETTATTTRWALLYMMLNPNIQEKASFRQLLVTVHQEIDSVLGQSAPSYAQRHLLPYTTATLAEVQRINSIVPLLVRGASR

DTTFNGYNIPQEGSLLVNLWSVHMDPQLFPEPNTFQPERFLDQDGNFVKHEALIPFSMGHRICLGEQLAKMELFMLFVSL

MQHFTFNLPEGAPEPSTVGKLGGLINVPLPFESCAVARG*

>e_gw.76.12.1|Brafl1

70% to estExt_GenewiseH_1.C_4770047|Brafl1

LSKQYGDVMTVWIGRDVNIIISGYKTIRNALVKRADEFSSRRIFPAVADLRGPGDTSTSTKGVLFAAYGPDWKHQRKFAL

MTLRDFGVGKRSLEGKIREEADALIQEVESKNGLKFDIKQMLPNAVSNVICSIAFGNRFEYGDPEFLRLIGLMNAAVEAQ

PSRDILPNIHPVFRRLPFGSPHQDKLVDLTLGLQVFCSEQIEKHRETFDPNDIRDFIDAFLLEQRQAQDERARENFTDKQ

LQELLFDLFIAGTETTATTTRWALLYMILNPDIQEKVRQEIDSVLGQAFPSYDQRNNMPYTTATLAEVHRINTIVPLTVP

HAASKDTTLNGYSIPADATLFFNLWSIHMDPQLFPEPDKFNPDRFLDQNGNFVKHEALVPFSIGHRVCLGEQLARMELFL

LFVSLMQRFTFHLPEGAPVPSTVGHFGGIVNVPHPFDMCAIPRE*

>gw.90.104.1|Brafl1 45% to CYP2P10

99% to e_gw.76.12.1|Brafl1

PFDIKQMLPNAVSNVICSIAFGNRFEYGDPEFLRLIGLLNAAVEAQPSRDILPNIHPVFRRLPFGSPHQDKLVDLTLGLQ

VFCSEQIEKHRETFDPNDIRDFIDAFLLEQRQAQDERARENFTDKQLQELLFDLFIAGTETTATTTRWALLYMILNPDIQ

EKVRQEIDSVLGQAFPSYDQRNNMPYTTATLAEVHRINTIVPLTVPHAASKDTTLNGYSIPADATLFFNLWSIHKDPQLF

PEPDKFNPDRFLDQNGNFVKHEALVPFSIGHRVCLGEQLARM

>fgenesh2_pg.scaffold_301000015|Brafl1

69% to estExt_GenewiseH_1.C_4770047|Brafl1

MCVSADISVSPAVQEPTTRTQGVATSREPPHSVFLPAALTELSKQYGDVMTMWNGRTPTIILTGYETIRTALVKRAEDFS

SRRSNAVLVNLRGDGITADGFIYAPDGPRLKQLRKFTLRTLRDFGVGKRSLEDKINEEGNTLVQEVLSQNGQTFDIRIML

QSAVCNIIFSIVFGDRLDYDNPDFLRLISLLNTATETKPTLSDILVFILPVFRYLQPSEASAVAKADKMYQALRKFCSEQ

IQKHRMTFDPKDIRDFLDAFLLEQHRATDERARETFSDKQLKEVLIDLFLAGTDTVAATLHWALLYMMVHQEIDSVLGQS

APSYAQRNLLPYTTATLAEVQRFKPVAPLSVQHTAPRDTTLNGYNIPQNAPILINLWSVHMDPQLFPEPNTFKPERFLDL

DGNFVKHEALIPFSMGHRVCLGEQLAKMELFLLFVSLMQRFTFHMPEGAPKPSMSGIYEVQFIVNLPCPFKLCAVPRG*

>e_gw.104.98.1|Brafl1 53% to CYP2D6

84% to fgenesh2_pg.scaffold_301000015|Brafl1

NLWSVHMDPQLFPEPNTFQPERFLDQDGNFVKHEALIPFSLGKGHRACLGEQLARMELFLLFVSLMQRFTFHLPEGAPEP

SMLGIYDHNTHVNLPFPFDLCAVPRG*

>gw.81.2.1|Brafl1

71% to estExt_GenewiseH_1.C_4770047|Brafl1

LTELSKQYGDVMTIWTGRFPAIVLSGYETIRTALVKRATEDFSSRGCNSPLVPGFLMAPCGPRWKQHRKFALMTLRDFGV

GKRSLEGKINEEAEALAQEVLSQNGQPFDLQIMMENCVCNIICSIVFGVRFEYGDPEFLRLIHSLNTTIEAKPTAIDTLE

VILPVFRHLRLSSETIEAKAVKMFRASQEFCGRQIEKHRLTFDPNDIRDFIDAFLLEQERAPDEGARANFTDKQLQEILI

DLLLAGTETSASAVHWALLYMMLNPEIQEKAKVHQEIDSVLGQSMPSYAKRNLLPYTAATLAEVQRIKPVAPLSVPHQAS

RDTTLNGYNIPYEGFVIVINLWSVHMDPRLFPEPDTFQPERFLDNHGNFLPRETLIPFGIGHRMCLGEQLAKMELFMLFV

SLMQRFTFKLPEGAPKPSMYGNF

 

$$$$$$$$

 

>e_gw.103.102.1|Brafl1 37% to CYP2U1

MFAGLLSEVSVRTIAVFLVIFLTLVVFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVV

VLNGYRAIKEALVDYKDAFSSRPNVYVLNVTSGFGKDFAFTPFNQAYKEKRKFAYSALRNLGMRMGPGSMEENIRDEARQ

LCLKVFFVDLSEQGDGHPRDIADNLTVSVANIICSMVFGKRYDYDDVEFVELTKTINNLFARVGSSQLMTVFPFLRFVPL

GRITFCTNEVNTFIRQEITKHREILDNENPRDFIDLILTELQTQEKADGVTEENSSWIIQDLFLAGVETTASSLQWGLLY

MVLCPEEQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATVMEILRIRVIAPLPLPHAPNEGTTFRGYDIPAGTKVLINL

WSATMDPEFWPDPEKFDPRRFLDSDGKVVSRPESFIPFGAGRRVCIGEQLSKMELFLLFSSLLKHFTFKLPEGAAAPSTD

GSLGLTLVPPSVKMCISRR*

>estExt_gwp.C_1030135|Brafl1

77% to e_gw.103.102.1

MRMGPGSVEENIREEARQLCLKLSEQGGAQPRDIADNLTVSVANIICSMVFGKRYDYDDEKFLKLSKIVNKLVASVGSSQ

LMMVFPFLRFVPGGRALLKIAKEVIAFVRQEITKHRETLDSENPRDFINLLLIELQTQNKTDCFTEENIVWIIQDLFVAG

LETTTTTLRWGLLYMVLCPEEQKKVQAELDSVLGTGHDVPTLAHRSQLPYTEATIMEIQRIRTITPLSGPHATTENTTFR

GHAIPAGTQVFPNLWSAQMDPEFWPDPEKFDPRRFLDSDGKVVTRPGSFMPFSTGRRVCLGEQLAKMELFLLFSSLLKHF

TFKLPEGAAAPSTDGITGITLVPPKVNMCITKR*

>estExt_gwp.C_3370069|Brafl1 51% to CYP2U1

100% to estExt_gwp.C_1030135|Brafl1

MVLCPEEQKKVQAELDSVLGTGHDVPTLAHRSQLPYTEATIMEIQRIRTITPLSGPHATTENTTFRGHAIPAGTQVFPNL

WSAQMDPEFWPDPEKFDPRRFLDSDGKVVTRPGSFMPFSTGRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAAAPSTD

GITGITLVPPKVNMCITKR*

>fgenesh2_pg.scaffold_103000083|Brafl1 48% to CYP2U1

83% to e_gw.103.102.1

MFAALLSEVSIRTIAVMLVVFLTLLVFFKRRKNLPPSPSGSWPVVGHLLSL

(gap)

GRAPHLKLTEWRKQYGDVYTVRMGMEDVV

VLNGYRAIKEALVDYKDAFSSRPNIYMTNLLT

GFGKVNSPKRILVEGIN

EVHVFLRQEITKHRETLDNENPRDFIDLLLT

ELQTQDKTDCVTEENIVWIIQDMFFAGIETTTTTLRWGLLYMVLCPEEQQKVQAELDSVLGADHDVPTLAHRSQLPYTKA

TVMEIQRIRAIVPLSTPHAPNENTTFRGYDIPAGTQVVPNLWSANMDPEFWPDPEKFDPRRFLDSDGKVVSRPESFMPFS

TGRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAAAPSTDGIMGATLVPPTINMCMSQR*

>e_gw.337.50.1|Brafl1 45% to CYP2U1

74% to fgenesh2_pg.scaffold_103000083|Brafl1

KILYDLTEMVTTVLRQEINCHRETLDRENPRDFIDLILNSILNKQETQEKTDGFTEENVVFIVLDMFVAGIDSTTITLRW

GLLYMVLHPEEQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATIMERIRAIAPLSVPHATVQDTTFRGYDIPAKTQVIG

NIWSAQMDSEFWPDPERFDPRRFLDSDGKVVTRPESFMPFSMDRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAPAPS

TVGTMGIGLKPQTVKLCLTLR*

>fgenesh2_pg.scaffold_103000077|Brafl1 44% to CYP2U1

95% to e_gw.337.50.1|Brafl1

MVTTVLRQEINCHRETLDRENPRDFIDLILNKQETQETDGFTEENVVFIVLDMFVAGIESTTITLRWGLLYMVLHPEEQQ

KVQAELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRAIAPLSVPHATVQDTTFRGYDIPAKTQVIGNIWSAQMDPEF

WPNPEKFDPRRFLDSDGKVVTRPESFMPFSMGRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAPAPSTYGTMGIGLKP

QTVKLCLTLR*

>fgenesh2_pg.scaffold_285000015|Brafl1

81% to e_gw.103.102.1

MGMEDVVVLNGCRAIKEALVDYKDAFSSRPSVYVLNLFSGFGKTYKEKRKFAYSALRNLGMRMGPGSMEENIREEGRQLC

LLSEQGDANPRDIADNLTVSVANITCSMVFGKRYDYDDVTFVELTKSINKLFAELGSSQLMTVFPFLRFVPGVNSSNRII

VECLNEVQAYLRHEITKHRENLDNENPRDFIDLLLTELQTQEKTDCLTEENIVFIIQDLFTAGVETTATTLRWGLLYMVL

CPEEQQKVQAELDSILGTDHDVPTLAHRSQLPYTEATIMEIQRIRAIGPLGGPHAPNEDTAFRGYDIPSGTQVLPNLWSA

HMDPEFWPDPEKFDPRRFLDSDGNVVRRQESFMPFSTGKFFFSNGRRACIGEQLAKMELFLLFSSLLRHFTFKLPEGAAA

PSTVGCLGLTYVPPTVNMCITKR*

>gw.354.51.1|Brafl1 41% to CYP2U1

78% to fgenesh2_pg.scaffold_285000015|Brafl1

ELDNILGTDHDVPTLAHRSQLPYIEATIMEIQRIRAIASLSGPHTVTEDTTFRGYDIPQEGSSLCILPNLWSAHMDPEFW

PDPDKFDLRRSLDSDGEVVCRPE

>e_gw.354.23.1|Brafl1 42% to CYP2U1

96% to fgenesh2_pg.scaffold_285000015, 2 aa diffs and the indel in yellow (allele)

HPRDIADNLTVSVANITCSMVFGKRYDYDDVTFVELTKSINKLFAELGSSQLMTVFPFLRFVPGVNSSNRIIVECLNEVQ

AYLRHEITKHRENLDNENPRDFIDLLLTELQTQEKTDCLTEENIVFIIQDMFTAGVETTASTLRWGLLYMVLCPEEQQKV

QAELDSILGTDHDVPTLAHRSQLPYTEATIMEIQRIRAIGPLGGPHAPNEDTAFRGYDIPSGTQVLPNLWSAHMDPQFWP

DPEKFDPRRFLDSDGNVVRRQESFMPFSTGRRACIGEQLAKMELFLLFSSLLRHFTFKLPEGAAAPSTVGCLGLTYVPPT

VNMCITKR*

>e_gw.292.28.1|Brafl1 42% to CYP2U1

92% to e_gw.354.23.1|Brafl1

SVANITCSMVFGKRYDYDDVTFVELTKSINKLFAELGSTIVFCTISYWIFFTVNSSNRIIVECLNDVQAYLRHEITKHRE

NLDNENPRDFIDLLLTELQTQEKTDCLTEENIVFIIQDLFTAGVETTASTLRWGLLYMVLCPEEQQKVHHTELDSILGTG

HDVPTLAHRSQLPYTEATIMEIQRIRAIGPLGGPHAPNEDTTFRGYDIPSGTQVLPNLWSAHMDPEFWPDPEKFDPRRFL

DSDGNVVRRQESFMPFSTGRRACIGEQLTKMELFLLFSSLLKHFTFKLPEGTAAPSTVGCLGLTYVPPTVNMCITKR*

>e_gw.354.20.1|Brafl1

96% to fgenesh2_pg.scaffold_285000015|Brafl1

82% to e_gw.103.102.1

KRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVR

MGMEDVVVLNGCRAIKEALVDYKDAFSSRPSVYVL

NLFSGFGKTYKEKRKFAYSALRNLGIKMGPGSMEESIREEGRQLCLKLSEQGDAN PRDIADNLTVSVANITCSMVFGKRY

DYDDVTFVELTKSINKLFAELGSSQLMTVFPFLRFVPGVNSSNRIIVECLNEVQAYLRHEITKHRENLDTENPRDFIDLL

LTELQTQEKTDCFTEENIVFIIQDLFTAGVETTASTLRWGLLYMVLSPEEQQKVQAELDSILGTDHDVPTLAHRSQLPYT

EATIMEIQRIRAIGPLGGPHAPNEDTTFRGYDIPSGTQVLPNLWSAHMDPEFWPDPEKFDPRRFLDSGGNVVRRQESFMP

FSTGRRACIGEQLAKMELFLLFSSLVKHFTFKLPEG

>e_gw.337.80.1|Brafl1

77% to e_gw.103.102.1

LTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPNVYVINLVTGCGKNIAFSKFNQAYKEKRKFAHSAL

RNLGMRMGPGSMEENIREEAQQFDAHPRDITDNDITDNLTVSVANIICSMVFGKRYDYDDEKFLELSNIISKLAAQLGSS

QLMTVYPFLRFIPGGRLLVECTNEILAFLRQEITRHRETLDDENPRDFIDLLLIELQTKEKTNYFTEENYEYIILDPFVA

GTETTVTTLRWGLLYMVLCPEKQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRAILPLNLPHAPNEETTF

RGYDIPAGTQILPNLWSANMDPEFWPDPKKFDPRRFLDSDGKVVTRPESFMPFSTGRRVCLGEQLAKMSLFLLFSSMLKH

FTFKLPEGATVPSTDGILGITLVPPKVNMCITKR*

>e_gw.103.112.1|Brafl1

78% to e_gw.103.102.1

LTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVGYKDAFSSRPNNYVLNLVSGSGKNIAFSKFNQAFKEKRKFAFSAL

RNLGMRMGPGSMEENIRDEAQQGDAQPRDTADNLTVSVANIICSMVFGKRYEYDDEKFLELSKIVNTLAAQLGSSQLMSV

FPFLRFIPGGRILVEFTNEVLAFLRQEITRHRETLDHDNPRDFIDLLLIELQTHGKTDFTEENIEWILQDLFIAGIATTV

TTLQWGLLYMVLCPEEQQKVQAELDSVLGTDHGVPTLAHRSQLPYTEATIREIQRIRAIFPLNLPHAPNEDTTFRGYDIP

AGTQILPHLWSANMDPEFWPDPEKFDPRRFLDSDGKVVTRPESFLPFSTGRRVCLGEQLAKMSLFLLFSSLLKHFTFKLP

EGAPAPSPDGCLGITLVPPKVNMCITKR*

>e_gw.337.39.1|Brafl1

82% to e_gw.103.102.1

PVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPNVYVLNLVSGFGKGTCVLL

SNFRTYLEKRKFAYSALRNLGMRMGPGSMEENIRDEARQLCLKLSEQGDAKPRDITDNLTVSVANIICSMVFGKRYDYDD

EKFLELSKIVNKLVASVGSSQLMTVFPFLRFIPGVNSTNRILLECIEDVHEFLRQEITKHRETLDNENPRDFIDLILTEL

QTQEKTDCFTEENIVWMIQDLFVAGIETTITTLRWGLLYMVLCPEEQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATI

MEIQRIRAIVPLSAPHAPNEDTTFRGYDIPAGTQVFPSLWSANMDPEFWPNPEKFDPRRFLDSDGKVVTRPESFMPFSTG

RRVCLGEQLAKMELFLLFSSLLKHFTFK

 

 

 

>e_gw.103.103.1|Brafl1

79% to e_gw.103.102.1

LTEWRKQYGDVYTVRMGIEDVVVLNGYRAIKEALVDCKDAFSSRPNVYVINLVTGCGKNIAFSKFNQAYKEKRKFAYSAL

RNLAMRMGPGSMEENIRDEARQLCLKVYSEQCDAHPHDITDNDITDNLTVSVANIICSMVFGKRYDYNDEKFLELSNIIS

KLAAQLGSSQLMTVYPFLRFIPGGRLLVECTNEILAFLRQEITRHRETLDDENPRDFIDLLLIELQTKEKTNYFTEENYE

YIILDPFVAGTETTVTTLRWGLLYMVLCPEKQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRAILPLNLP

HAPNEETTFRGYDIPAGTQILPNLWSANMDPEFWPDPEKFDPRRFLDSDGKVVTRPESFMPFSTGRRVCLGEQLAKMSLF

LLFSSMLKHFTFKLPEGATVPSTDGILGITLVPPKVNMCITKR*

>e_gw.337.78.1|Brafl1

80% to e_gw.103.102.1

LTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPNNYVLSLLTGFGKDIVFSPFNQAYKEKRKFAYSAL

RNLGMRMGPGSVEENIREEARQLCLKLSEQGGAQPRDTADNLTVSVANIICSMVFGKRYDYDDEKFLQLSKIVNKLVARV

GSSQLMMVFPFLRFVPGGRALLQIAKEVIAFVRQEITKHRETLDSENPRDFIDLLLIELQTQNKTDCFTEENIVWIIQDL

FVAGLETTTTTLRWGLLYMVLCPEEQQKVQAELDSVLGTGHDVPTLAHRSQLPYTEATIMEIQRIRTITPLSGPHATTEN

TTFRGYAIPAGTQVFPNLWSANMDPEYWPDPEKFDPRRFLDSDVKLVTRPESFMPFSTGRRVCLGEQLAKMELFLLFSSL

LKHFTFKLPEGAAAPSTDGITGITLVPPKVNMCITKC*

>e_gw.337.6.1|Brafl1

78% to e_gw.103.102.1

APHLKLTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSNRPDVYLLNLISGFGKDIAISKFNQAYKEKRKF

AYSALRNLGMRMGPGSMEENIREEARQLCMKLSEQGDAHPRDIADNLTVSVANIICSMVFGKRYDYDDEKFLELSKIVNK

VAAQVGSSQLMAVFPFLRILVECIEETHAFLREEITQHRETMDNENPRDFIDLLLNELQKTDCFTEENIDWIIQDLFFAG

IETTVTSLRWGLLFMVLCPEEQQKVQAELDSILRTDHDVPTLAHRSQLPYTEATIMEIQRIRAILPLGVPRAPNEDTTFR

GYDIPAGTQVLPNLWSAHMDPEYWSDPEKFDPRRFLDSDGKVATRPESYMPFSTGRRVCLGEQLAKMELFLIFSSLLKHF

TFKLPEGAAAPSTDGCMTITLVPPTINMCINRR*

>e_gw.337.79.1|Brafl1

82% to e_gw.103.102.1

LTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPNVYMLNLVSGFGKGIGLTKFDHVYKEKRKFAYSAL

RNLGMRMGPGSMEENIREEARQLWDAQARDIADNLTVSVANIICSMVFGKRYDYDDVKFVELTKIVNKLHAQLKSSQLMT

VFPFLRFIPGGRIVFVILFEYLNEVHTFIRQEITKHRETLDNKNPRDFIDLLLNELQTQEHTDCFTEENIVWIVQGLFLA

GVETTANSLRWGLLYMVLCPEEQHKVQAELDSVLGADHDVPTLAHRSQLPYTEATIMEIQRIRAILPLNLPHATNEDTTF

RGYDIPAGTQVLPNLWSANMDPEFWPDPEKFDPRRFLDSDGKVVTRQESFLPFSAGRRVCIGEQLAKMELFLLFSSLLKH

FTFKLPEGAAAPSTDGSLGITLVPPGVNICITKR*

>e_gw.103.104.1|Brafl1 35% to CYP2U1

95% to e_gw.337.79.1|Brafl1

LTEWRKQYGDVYTVRMGMEYVVVLNGYRAIKEALVDFKDAFSSRPNVYMLNLVSEFGKGMLVGFSPIFAENHSDKTSLRV

RRFLNSCEGEMVPSICVILHTLSPTYRHTTLDSFVCSNSLYISGIGLTKFDHVYKEKRKFAYSALRNLGMRMGPGSMEEN

IREEARQLLNSTNRILVEYLNEVHTFIRREITKHRETMDNKNPRDFIDLLLNELQAQEHTDCFTEENIVWIVQGLFLAGV

ETTANSLRWGLLYIVLCPEEQHKVQAELDSVLGTDHDVPTLAHRFQLPYTEATIMEIQRIRAILPIPLNLPHATNEDTTF

RGYDIPAGTQVLPNLWSANMDPEFWPDPEKFDPRRFLDSDGKVVTRPESFLPFSAGRRVCLGEQLAKMELFLLFSSLLKH

FTFKLPEGAAAPSTDGSLGITLVPPRVNICITKR*

>e_gw.103.16.1|Brafl1

79% to e_gw.103.102.1

APHLKLTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSNRPDVYLLNLISGFGKDIAISKFNQAYKEKRKF

AYSALRNLGMRMGPGSMEENIREEARQLCMKLSEQGDAHPRDITDNLTVSVANIICSMVFGKRYDYDDEKFVELSKIVNK

VAAQVGSSQLMAVFPFLRFIPGGKILILVECIEETHAFLREEITQHHETLDNENPRDFIDLLLNELQKTDCFTEENIDWI

IQDLFFAGIETTVTSLRWGLLFMVLCPEEQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRAILPLGVPRA

PNENTTFRGYDIPAGTQVLPNLWSAHMDPEYWSDPEKFDPRRFLDSDGKVVTRPESFMPFSTGKFFSKSTRSRRVCLGEQ

LAKMELFLIFSSLLKHFTFKLREGAAAPSTDGHMTITLVPPTINMCINRR*

>e_gw.337.25.1|Brafl1

81% to e_gw.103.102.1

APHLKLTEWRKQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPNNYVLNIVSGSGKNIAFSKFNQAYKEKRKF

AYSALRQLGMRMGPGSMEENIRDEARQLCLKVLSEQRDAQPRDIADNLTVSVANIICSMVFGKRYDYDDEKFLELSKIVN

TLVAQVGSSQLMSVFPYLRFIPGGRILVEFTNEVLAFLRQEITRHRETLDHDNPRDFIDLLLIELQTHGKTDFTEENIEW

ILQDLFIAGTETTVTTLQWGLLYMVLCPEEQQKVQAELDSVLGTDHGVPTLAHRSQLPYTEATIMEIQRIRAIFPLNLPH

APNEDTTFRGYDIPAGTQILPNLWSANMDPEFWPDPAKFDPRRFLDSDGKVVTRPESFLPFSTGRRVCLGEQLAKMSLFL

LFNSMLKHFTFKLPEGATIPSTDGILGITLVPPKVNMCITKR*

>e_gw.103.108.1|Brafl1 35% to CYP2U1

80% to e_gw.103.102.1

TMLAALLSEVSIRTIVVVCVVFLTLLVFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDV

VVLNGYRAIKEALVDYKDAFSSRPSVYLLNLVSGFGKDIALSKFNQAYLEKRRFAASALKTLGMRMGPGSVEEHIREEAR

QLCIKLSEQGDGHPRDIADNLTVSVANIICSMVFGKRYGYDDEKFVELTKIIHKLLSQFEHGSSQLMTVFPFLRFVPGAN

RILVECINKVHEFLRQEIIKHRETLDNENPRDFIDLILTELQTQEQTDCFTEENIVWIIQNMFFAGMETTANTLRWGLLY

MVLCPEEQQKVHAELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRLVAPLNAPHAATEDTTFRGYDIPAGMQVLTNL

WSAHMDPEYWPDPETFDPRRFLDSDGKVVSRPDSYLPFSAGRRVCLGEQLAKMELFLLFSSLLKHFTLKLPEGVAAPSAD

DCMGLSPPTVNMCVTRR*

>e_gw.337.95.1|Brafl1 36% to CYP2J2

85% to e_gw.103.108.1|Brafl1

EQYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPSFTSRVSMHDIPHIYLTDIALSKFNQAYLEKRRFAVSALK

TLGMRMGPGSVEEHIREEARQLCIKLSEQGDGHPRDIADNLTVSVANIICSMVFGKRYGYDDEKFVELTKIIHKLLSQFE

HGSSQLMTVFPFLRFVPGVNSSNRILVECMEEVHAFLRQEITKHRETMDKENPRDFIDLLLAELETQEKTDCFKEENIEW

IIQDLFVAGVETTATTLRWGLLYMVLCPEEQQKV

>estExt_fgenesh2_pm.C_530020|Brafl1

88% to e_gw.103.108.1|Brafl1

79% to e_gw.103.102.1

MFPALLSEVSIQIIAVASAVFLTLLVFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVV

VLNGYRAIKEALVDYKDAFSSRPNVYVLNLVSGFGKDIAFTKFNPAYLEKRRFAVSALKNLGMKMGPGSVEEHIREEARQ

LCLKLSEQGDAHPRDIADSLTVSVSNIVCSMVFGKRYDHDDEKFVELMKIVHKVLSQLEHGSSQLMMVFPFLRFIPGVNS

TNRILVECINKVHEFLRQEITKHREILDSENPRDFIDLILTELQTKEKTDCFTEENIVWIIQNMFFAGTETTANTLRWGI

LYMVLCPEEQQKVQSELDSVLGTDHDVPTLAHRSQLPYTEATIMETQRIRLVAPLNAPHAPNEDTTFRGYDIPAGTQVLT

NLWSAHMDPEYWANPEKFDPRRFLDTEGKVVSRPDSYLPFSAGRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAAAPS

ADDCMRVTPPRVNMCITRR*

>estExt_gwp.C_950023|Brafl1

86% to e_gw.103.108.1|Brafl1

78% to e_gw.103.102.1

MFSALLSEVSIQIMAVASAVFLTLLVFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVV

VLNGYRAIKEALVDYKDAFSSRPNVYVLNLVSGFGKDIAFTKFNPAYLEKRRFAVSALKNLGMKMGPVSVEEHIREEARQ

LCLKLSEQGDAHPRDIADSLTVSVSNIVCSMVFGKRYDHDDEKFVELIKIVNKVLSQLEHGSSQLMMVFPFLRFIPGVNS

TNRILVECIDKVHEFLRQEITKHREILDSENPRDFIDLILAELQTKDKTDCFTEENIVWIIQNMFFAGTETTVSTLRWGI

LYMVLCPEEQQKVQSELDSVLGTDHDVPTLAHRSQLPYTEATIMETQRIRLVAPLNAPHAPNEDTTFRGYDIPAGTQVLT

NLWSAHMDPEYWANPEKFDPRRFLDTEGKVVSRPDSYLPFSAGRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAAAPS

ADDCMRVTPPRVNMCITRR*

>e_gw.292.39.1|Brafl1 48% to CYP2U1 short intron in heme region

91% to fgenesh2_pg.scaffold_337000019|Brafl1

VLPILWSAHMDPEFWPDPEKFDPCRFLDADGKLVTRPESFMPFSTGKFFFQRPTKAKVCRRACLGKQLAKMELFLLFSSL

LQHFTFKLPEGTAEPSTDGSLGLTLAPPRVNMCIIQR*

>fgenesh2_pm.scaffold_285000010|Brafl1 41% to CYP2U1

83% to e_gw.292.39.1|Brafl1

MVFGKRYEYDDVKFVELTKIVNKQFAQVGSSQLMTVFPFLRFIPIEITKHRETLDNGNPRDFIDLLFIEIQTQGKTDYFT

EENIVWIIEDLSVAGMETTANTLRWGLLYMVLFPEEQKKVQVELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRAIL

PLSIPHTPNEDTKFRGYDIPAGMQVLPNLWSAQMDPEFWPDPERFEPRRFLDSEGKVFTRPESFMPFCTGRRVCLGEQLA

KMELFLLFSSLLKHFTFKLPEGATVPSTDGCMGITLVPPRVNMCITQR*

>e_gw.97.240.1|Brafl1 44% to CYP2U1

88% to e_gw.292.39.1|Brafl1

SVANIICSMVFGKRYDYDDFEFVELTKTVNKLLAQLNSSQPMTVFPFLRFIPGGRIVFVILTECINEVHAFIRQEITKHR

ETLDNENPRDFIDLLLTELQTQEKTNCFTEENIVWIIQGLFAAGVDTTANTLRWGLLYMVLCPEEQQRVQAELDSVLGTG

HDVPTLAHRLQLPYTEATIMEIQRIRAIVPVTPHAPNEDTTFRGYDIPAGTQVLPNLWSANMDPEFWPDPEKFDPRRFLD

SDGKVVTRPESFMPFSTGRRVCLGEQLAKMELFLLFSSLLKHFTLKLPEGAAAPSTDGIMGFFYVPPKVNMCITKR*

>fgenesh2_pg.scaffold_128000045|Brafl1 495 to CYP2U1

98% to e_gw.97.240.1|Brafl1

MVFGKRYDYDDVKFVELTKIINKQVAKFGSSQLMTVFSFLRFMPGGHDVPTPAHRSQLPYTEATIMEIQRIRAIVPVTPH

APNEDTTFRGYDIPAGTQVLPNLWSAHMDPEFWPDPEKFDPRRFLDSDGKVVTRPESFMPFSTGRRVCLGEQLAKMELFL

LFSSLLKHFTLKLPEGAAAPSTDGIMGFFYVPPKVNMCITKR*

>e_gw.285.81.1|Brafl1 46% to CYP2U1 92% to e_gw.292.39.1|Brafl1 w/o intron

YLRHEITKHRENLDNDNPRDFIDLLLIELQTQEKTDCFTEENILFIIEDLFFGGVETTVTTLRWGLPYMVLCPEEQQKVQ

AELDSILGTDHDVPTLAHRSQLPYTEATIMEIQRIRALVPLGGPHAPNEDTTFLGYDIPSGTQVLPILWSAHMDPEFWPD

PEKFDPCRFLDADGKVVTRPESFMPFSTGKFFSKDQQKQKCRRVCLGKQLAKMELFLLFSSLLKHFNFKLPEGAAAPSTD

GCLGLTLAPPTVNMCIIQR*

>fgenesh2_pg.scaffold_337000019|Brafl1 40% to CYP2U1

87% to fgenesh2_pg.scaffold_103000079|Brafl1

87% to fgenesh2_pg.scaffold_103000086|Brafl1

83% to e_gw.354.22.1|Brafl1

84% to e_gw.103.102.1

MFAALLSEVSIRTIAVMLVVFLTLLVFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVV

VLNGYRAIKEALVDYKDAFSSRPNIYMFNLLTGFGKDIGLAKFNQAYKEKRKFAYSALRNLGMRMGPGSVEENIRDEARQ

LCLKLSEQGPDAQARDIADNLTVSVANIICSMVFGKRYDYDDVKFVELTKIVNKLIAQLGSSQLMTVFPFLRFIPGVNSP

KRILVEGINEVHVFLRQEITKHRETLDNENPRDFIDLLLIELQTQDKTDCVTEENIVWIIQDMFFAGIETTATTLRWGLL

YMVLCPQEQQKVQAELDSVLGTGHDVPTLAHRSQLPYTKATVMEIQRIRAIVPLSSPHAPNEDTTFRGYDIPAGTQVLPN

LWSANMDPEFWPDPEKFDPGRFLESDGKVVTRPESFMPFSTGRRVCLGEQLAKMELFLLFSSLLKHFTFKLPEGAAAPST

DGCMGITLVPPTINMCMSQR*

>fgenesh2_pg.scaffold_285000038|Brafl1 33% to CYP1A1

85% to fgenesh2_pg.scaffold_337000019|Brafl1

MLVEVGRYTCLLSQFETFGVRTMFSALLSQVSIRTIAAFWVIFLTLLVFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLK

LTEWRKRYGDVYTVRMGMEDVVVLNGYRAIKEALVDYKDAFSSRPNNYVLNLVTGSGKVVDIRARIYLTDIALAKFNQAY

KEKRKFAYSALRTLGMRMGPGSMEENIRDEARQLCLK

>e_gw.97.29.1|Brafl1 35% to CYP2U1

78% to fgenesh2_pg.scaffold_337000019|Brafl1

FNQAYKEKRKFAYSALRNLGMRMGEGSMDRREHQIRGSSALSEGDAQSRDIADSLTVSVANIICSMVFGKRYDYDDVKFV

ELTKIINKQVAKFGSSQLMTVFSFLRFMPGVNSSNRILVECIDEVHAFLRQEITKHRETLDNENPRDFIDLLLTELQTQE

HTDCFTEDNIVWIIQDLFVAGMGTTANTLRWGLLYIVLCPEEQQRVQAELDSVLGTGHDVPTPAHRSQPPYTEATIMEIQ

RIRAIAPLSGPHAPNEDTTFRGYDIPAGTQVIMNKSAIHSGLTSHNDIFTIIQLFLDSDGKVVTRPESFIPFSTGRRACL

GEQLAKMELFLLFSSLLKHFTLKLPEGAAAPSTDGCMGITLVPPRVNICITKR*

>fgenesh2_pg.scaffold_103000079|Brafl1 87% to fgenesh2_pg.scaffold_337000019|Brafl1

81% to e_gw.103.102.1

LMFAALLSEVSIRTIAVIWVVFLTILVFFKRRKMDPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDV

VVLNGYRAIKEALVDYKDAFSSRPNVYVLNLVSGFGEDIVMSPFNQAYKEKRKFAYSALRTLGMRMGPGSMEENIRDEAR

QLCLKLSEQGDAQPSDITDNLTVSVANIICSMVFGKRYDYDDENFLELSKVANKLVAQLGSSQLMTVFPILRFVPGVNSS

NRILVECMEEVHAFLRQEITKHRETMDKENPRDFIDLLLAELETQEKTDCFKEENIEWIIQDLFVAGVETTATTLRWGLL

YMVLCPEEQQKVQAELDSVLGADHDVPTLAHRSQLPYTEATIMEIQRIRAIVPLAAPHTPNENTTFRGYDIPAGTQVFPN

LWSANMDPEFWPDPEKFDPRRFLDSDGKVVTRPESYMPFSTGRRVCLGEQLAKMELFLLFSSLLKHVTFKLPEGAAAPST

DGCMGITLVPSRINMCISQR*

>fgenesh2_pg.scaffold_103000086|Brafl1 87% to fgenesh2_pg.scaffold_337000019|Brafl1

84% to e_gw.103.102.1

MFAALLSEVSIRTIAVFLVVFLTLLVFLKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVV

VLNGYRAIKEALVDYKDAFSSRPNVYVLNLVSGSGKSIALSPFNQAYLEKRKFAYSALRNLGMRMGPGSMEENIREEARQ

LCIKLSELGDAHPRDIADNLTVSVANIICSMVFGKRYDYDDVKFVELTKLTNKLFARIGSSQLMTVFPFLRFIPGANSTV

RILVECLNELHSFIRQEIEKHRETLDNENPRDFIDLTLTELQAQEKTDCLTEENIVRIIQDLFVAGIETTVTTLRWGLLY

MVLCPEEQQKVQAELDSVLGTDHDVPTLAHRSQLPYTEATIMEIQRIRTIGPLGGPHAATEDTTFQGYDIPAGTQVFPNL

WSANMDPEFWPDPETFDPRRFLDSDGKVFSRPESFMPFSTGRRVCLGEQLAKMELFLLFTSLLKHFTFKLPEGAAAPSTD

GCLGITLVPSKGLSQSATL*

>estExt_fgenesh2_pg.C_18360001|Brafl1 36% to CYP2X10 N-term

88% to fgenesh2_pg.scaffold_103000086|Brafl1

MSAVWGAALSLFFSGHFIQTVAVCFVVFLTILVFFKRRKNLPPSPNGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVR

MGMEDVVVLNGYRAIKEALVDYKDAFSSRPNNYVLSLLTGFGKDIVFSPFNQAYKEKRKFAYSALRNLGMRMGPGSVEEN

IREEARQLCL KHFTFKLPEGAAAPSTDGITGITLVPPKVNMCITKR*

>e_gw.354.22.1|Brafl1 83% to fgenesh2_pg.scaffold_337000019|Brafl1

possible assembly error in yellow region

79% to e_gw.103.102.1

MFSTLLSEVSIRTIAVFLVVFLTLLFFFKRRKNLPPSPSGSWPVVGHLLSLGRAPHLKLTEWRKRYGDVYTVRMGMEDVV

VLNGCRAIKEALVDYKDAFSSRPSVYVLNLISGFGKNIGVSKFNQAYKEKRKFAYSALRNLGIKMGPGSMEESIREEGRQ

LCLKLSEQGDARPRDITDNLTVSVANIICSMVFGKRYDYDDVTFVELTKSINKLVAQLGSSQLMAVFPFLRFIPGVNSSN

RVLVECLNEVQAYLRHEITKHRENLDNENPRDFIDLLLTELQTQEKTDCLTEENIMFIIQDLFTAGVGTTVTTLRWGLLY

MVLCPEEQQKVQAELDSILGTDHDVPTLAHRSQLPYTEATIMEILRIRSIVPLTPHAPNEDTTFRGYDIPSGTQVLPILW

SAHMDPEFWPDPEKFNPCRFLDADGKVVTRPESIICLFFNFFSLSYSTGRRACLGKQLAKMELFLLFSSLLKHFTFKLPE

GAAAPSTDGCLGLTLAPPIVNMCIIQR*

>e_gw.354.40.1|Brafl1 38% to CYP1A1

96% to e_gw.354.22.1|Brafl1

ASVSSCLVSFLLKHFTFKLPEGALRPVGSWPVVGHLLSLGRAPHLKLTEWRKQYGDVYTVRMGMEDVVVLNGCRAIKEAL

VDYKDAFSSRPSVYVLNLFSGFGKNLGFSKFNQAYKEKRKFAYSALRNL

 

$$$$$$$$

 

>fgenesh2_pm.scaffold_196000021|Brafl1 29% to CYP2U1

MTEAILDTAAAAVASPTENVQTFLVLMLGLLAGYLLWRRVNPPNLPPGPWGLPGLGAIPFLGLAPHETLMTMSKAYGDIM

SVRLGPKLAVVLNGQRAIHQALIKRAGVFSDRPGFELVNMVHKGRGIIAGPSTDFVQRQRRFLMRSFRTLGLNTHNIENC

LQAEVQTLMTTLKQVQGNSGEVYDVINRSVVNAIAV QSQRPEVPPPGLLLGRRVPLLLHR QFLEDGDNFLSIIRDIVKSR

RQVFAEILQKDPTLDDFKPSDILDCYFQETTRGQAWFMSDEDFCHMIMDNYIAGTTTTRLTMQWAMLLLTISPREQTKMH

DEIVSVVGTDRLPSLKDKDNLPYTKAAIFELLRISCVTPLSLPREAADDVIIDGHRIPKGTMVMTNLWSVTNDPDVWEDP

RTFKPERFLNEQGECVLPKEWLPFSTELHIIHCKKCSVSAGLYGTVL*

>e_gw.236.15.1|Brafl1

100% to fgenesh2_pm.scaffold_196000021|Brafl1

LAPHETLMTMSKAYGDIMSVRLGPKLAVVLNGQRAIHQALIKRAGVFSDRPGFELVNMVHKGRGIIAGPSTDFVQRQRRF

LMRSFRTLGLNTHNIENCLQAEVQTLMTTLKQVQGNSGEVYDVINRSVVNAIAV

FSFGNRFNHNDPKFHRLVSCLEGVFRFSSTGVGLMTQAFPVLLKFPRGLPGLS

QFLEDGDNFLSIIRDIVKSRRQVFAEILQKDPTLDDFKPSDILDCYFQETTRG

QAWFMSDEDFCHMIMDNYIAGTTTTRLTMQWAMLLLTISPREQTKMHDEIVSVVGTDRLPSLKDKDNLPYTKAAIFELLR

ISCVTPLSLPREAADDVIIDGHRIPKGTMVMTNLWSVTNDPDVWEDPRTFKPERFLNEQGECVLPKEWLPFSTGV*

 

$$$$$$$$

 

>e_gw.239.63.1|Brafl1 41% to CYP2P10 danio, 40% to CYP2U1 human

MTEWAKTYGPVYRIQLGRRTVVVLSGYAVMHEALVKRGEDFSSRPNDPVTKLINPQRLGIISAPFGTPWKEHRKFTLMSL

REFGFGKRSLEGKILEESVALQAEIMKMGNKPFNIRRMVQNAVTNVICSIVFGSRFEYNDDKFTRLMDALDRGLSFNFFG

QIAVFFPILRRVPGLGKGPQIMLDLIGTVRAYLREEMDSHKKTFDSNDIRDLIDSYVRETKSREKDDETTFTDEYTEMVL

FDMFVAGSETTSTTLYWAFLYMILNPDIQAKVQEEIHSVLGYDKPPSTAHRAQMPYTEAVLTEVARIGTILPTSVTRATS

RDTSFHGYNIPEGTAVLPNLWSVHHDPQHFPNPGKFDPGRFLDAQGRYQRDDHVMPFGLGPRICLGKQLAEMELFVFFTS

LLQHFTFNLPEGAAKPTTTGINGITHSPKNFELVAEPLA*

>estExt_fgenesh2_pg.C_1340003|Brafl1 top part not P450

MPNNYEVDEMIAFKGTTEDKDPVPWFGRVVVSKPLKYHRLRRSTLQEAIMTHRMIRTQDYRIVVAFFIVYDLTRTIIHLM

DIFWELMLSAWLFISRFIVILFSLTLPSFRTRRAARDRFILPSGPAFQIKATELDSVDKIYEKISDVTGMPKTSFKIFTA

GKKVRHPCQGVARSRTTATKPASKNNAHSRQETRDSTLHGEETRDCGGACNCHTSTSNKEENCDLPVGRIKDAI

39% to CYP2J2, 97% to e_gw.239.63.1

RSKRII

SAPFGTPWKEHRKFTLMSLREFGFGKRSLEGKILEESVALQAEIMKMGNKPFNIRRMVQNAVTNVICSIVFGSRFEYNDD

KFTRLMDALDRGLSFNFFGQIAVFFPILRRVPGLGQGPQIMLDLMGTIRAYLREEMDSHKKTFDSNDIRDLIDSYVRETK

SREKDDETTFTDGYTEMVLFDMFVAGAETTSTTLYWAFLYMILNPDIQ

(gap) 52% to CYP2C8

AKPNLWSVHHDPQHFPNPGKFDPGRFLDAQGQYQRDDHVM

(gap) 53% to CYP2D6

PFGLGPRICLGKQLAEMELFVFFTSLLQHFTFNLPQGAAKPTTTGINGITHSPKNFELVAEPLA*

>estExt_fgenesh2_pg.C_1140040|Brafl1

85% to e_gw.239.63.1|Brafl1

MAAQLVTSLVGENVILQTALVLLLVFVVTSWFFKTPKNLPPGPRGWPVAGNIFSLAMGHSFKTMTEWAKTYGPVYRIQLG

KETMVVLSGYDVMHEALVKRGEDFSSRPDLPVVKLVNPKRLGIITAPFGTPWKEHRKFTLMSLREFGFGKRSLEGKIMEE

SVALQSEIMKMGNRPFDISRMVQNAVTNVICSIVFGSRFEYNDVKFTQLMDALDRGFANNLLGQLAIFFPILRRVPGIGR

GAQLIVDVTATVTAYLREEMDSHKKTFDPNDIRDIIDSYVRETKSREHDDETTFTDEYTEIVLFDLFIAGAETTSTTLYW

AFLYMILNPDIQQKVQEEIHSVLGHDKPPSTAHRAQMPYTEAVLTEVGRIGTILPTSVFHATSRDTSFHGYDIPEGTTVL

PNLWSVHHDPEHFPNPGKFDPGRFLDAQGRYQRDDHVMPFGIGPRMCLGKQLAEMELFVFFTSLLQHFTFKLPEGAAKPS

TTGINEGAAAPSTTGINGVTHSPKNFKLVAEPLA*

>fgenesh2_pg.scaffold_114000031|Brafl1 49% to CYP2U1

88% to estExt_fgenesh2_pg.C_1140040

MPVRMLTIRTLTYTKLKMAAQLVTSLVGENVILQSALVLLLVFLVTSWFFKTPKNLPPGPRGWPVAGNIFSLAMVQDEIH

SVLGHDKPPSTSHRAQMPYTEAVLTEVARIGTILPTSVFHATSRDTSFHGYDIPEGTTVLPNLWSVHHDPEHFPNPGKFD

PGRFLDAQGQYQRDDHVMPFGIGPRMCLGKQLAEMELFVFFTSLLQHFTFKLPEGATKPSTMGISGVTHSPKNFELIAEP

LA*

>fgenesh2_pg.scaffold_114000072|Brafl1

86% to e_gw.239.63.1|Brafl1

MTEWAKTYGPVYRIQLGRETMVVLSGYDVMHEAFLKRGEDFSSRPFNPIVALINPKRIGILGAPFGTPWKEHRKFTLMSL

REFGFGKRSLEGKILEESVALQAEIVKMGNKQFDISRMVQNAVTNVICSIVFGCRFEYTDGKFKHLMDALDRAFATNLFG

QLAVFFPILRRVPGLGRGAQIIVDAVGTIKAYIREEMDSHKKTFDSNDIRDIIDTYVRETKSREDDDETTFTDENTERVL

FDLFIAGAETTSTTLYWAFLYMILNPDIQQKVQDEIHSVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTILPTSVFHATS

RDTSFHGYDIPEGTTVMPNLWSVHHDPEHFPNPGKFDPGRFLDAQGRYQRDDHVMPFGIGPRMCLGKQLAEMELFVFFTS

LLQHFTFKLPEGAAKPSTTGINGITHSPKNFKLQAEPLA*

>fgenesh2_pg.scaffold_114000030|Brafl1 green = 41% to CYP2U1 N-term

90% to fgenesh2_pg.scaffold_114000072|Brafl1

MTEWAKTYGPVYRIQLGRETMVVLSGYDVMHEALVKRGEDFSSRPNNPLFKILNPERLGIVTAPFGTPWKEHRKFTLMSL

REFGFGKRSLEGKILEESVALQAEIVKMGNKQFDISRMVQNAVTNVICSIVFGCRRFKMAARAEYFLVAVVLYVIIPTVC

AQQGIPLADRSPGVYQPIGVQDDTIIKDDQMTASSQVSGSEAYRGRLNGDGAWQPSGQGTEFLAVNLQYNRYIFGIQTQG

QGDGYVETYRIVYQVDNGTDLILYSEGSGSAKIFSGNSDNETIVQQNFTSYIYARYILVNPQNFSGAPRLRIELLGVDEL

PTTISPVTTPLVTTLSTPYLTQPQSTTEAETSSGVYQPIGIQDATIIPDALMSASSQVNGSEAYRGRLNGDGAWQPAGQG

TEFLAVNLQYNRYIFGIQTQGQGDGYVETYRIVYQVDNGTDLILYSEGGGSAKIFSGNSDNETIVQQNFTSYIYARYILV

NPQNFSGAPRLRIELLGVDELPTTISPVTTPLVTTLSTPSSTQPQSTTEAETSSGVYQPIGVQDDTIILDDLMHASSQVN

GSEAYRGRLNGDGAWQPSGQGTEFLAVDLQYNRYIFGIQTQGQGDGYVETYRIIYQVDNTSGLVLYSEDGGSAKIFSGNS

DNETIVQQNFTSYIYARYILVNPETFSGAPRLRIELLGVDELPTTISPVTTPLVTTLSTPSSTQPQSTTAKSSGVYQPIG

VEDNSIITNGQMTSSSEVTGSEAYRGRLNGDGAWQPSGQGTNEFLAVNLQYNRYIFGIQTQGHGNGYVETYRILYQVDNT

TDLVLYSEDGGSAKIFSGNIDNETIVQQNFSLYIYARYILVNPQNFSGAPRLRIELLGVDELPTTISPVTTPLVTTLSTP

YLTQPQSTTEAETSSGVYQPIGVQDATIIPDALMSASSQVNGSEAYRGRLNGDGAWQPSGQGTEFLAVNLQYNRYIFGIQ

TQGQGNGYVETYRIVYQMDNGTDLILYSEGGGSAKIFSGNSDNETIIQQNFTSYIYARYILVNPQNFSGAPRLRIELLGV

DELPTTNSPTSPLPLTSTQRTATSVSAQTSRTKNGGPSPSVTTIDPELPTLIFPATTHPRTTTTSKATSVPSQTSKTSTR

GQNPSTTITTTTPVPGQSSNVINVGAAAAAGSGGVIFLLLIVVAVILFIRRRRKKRDRAPSVEETPSNSTGYVNASFVTI

PGGADDACRQDFQQEVDIMRHVGYHPNIVNLLGFCTYQGNGDLLKFLRKSRVQEAASPTYVNRPKFEGVRTLSTLSPVQM

LRIACDVATGMDHLSSKQKAIPFRSTALEALTRRIYTTKSDVWSFGILLWEIVTIGGTPYCGMKSRTILGRLREGYRLPK

PRNCEADLYQLMLLCWKTRPEDRPSFTDLAEQLEIMIEDKHSYVNVDKDDDFEYEMVDTSDSDVA*

>estExt_gwp.C_280275|Brafl1

86% to e_gw.239.63.1|Brafl1

MAAAQLVTSLVGENVILQTALVLLLVFVATSWFFSTPKKLPPGPRGWPVVGNVFSLAMGHRFLTMTEWAKTYGPVYTIKL

GRETTVILSGYDVMHEALVKRGEDFSTRPTDPLTKLLNPQRLGIIAAPFGTPWKEHRKFTLMSLREFGFGKRSMEGKILE

ESVALQAEILKMGNKPSDISRMVQNAVTNVICSIVFGSRFEYNDDKFTRLMDILDRAFSLNVFGQIAVFFPFLRRVQEWE

KAHKAYLREEMDSHKKTFDSNDIRDLIDSYVRETKSRENDEETTFTDEYTERVLFDLFIAGAETTSTTLYWAFLYMILNP

DIQAKVQEEIHTVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTILPTGVTHATSRDTSFHGYDIPEGTLVLPNLWSVHHD

PEHFPNPGKFDPSRFLDAQGQYQRDDHVMPFGIGPRICLGKQLADMELFVFFTSLLQHFTFKLPEGASKPTTTGINGLTH

SPKNFNLVAEPLA*

>estExt_fgenesh2_pg.C_280128|Brafl1 41% to CYP2U1

91% to estExt_gwp.C_280275|Brafl1

MAAAHTPKNLPPGPRGWPVVGNVFSLAMLGRETTVILSGYDVMHEALVKRGEDFSTRPTDPLTKLLNPQRLGIIAAPFGT

PWKEHRKFTLMSLREFGFGKRSMEGKILEESVALQAEIIKMGNKPFDISRMVQNAVTNVICSIVFGSRFEYNDDKFTRLM

DVLDRAFSLNVFGQIAVFFPFLRRVPGMGKGPQVLIDLTFDSNDIRDLIDSYVRETKSRENDEETTFTDEYTERVLFDLF

IAGAETTSTTLYWAFLYMILNPDIQTKVQEEIHSVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTILPTGVTHATSRDTS

FHGYDIPEGTLVLPNLWSVHHDPEHFPNPGMFDPGRFLDAQGQYQRDDHVMPFGIGPRICLGKQLAEMELFXLFTSLLQH

FTFKLPEGAAKPTTTGMNGLTHSPKNFDLVAEPLA*

>fgenesh2_pm.scaffold_457000002|Brafl1

82% to e_gw.239.63.1|Brafl1

MTEWAKTYGPVYRIQLGRETVVVLSGYDVIQEALVKRGEDFSNRPANSIVKLMYPKMLGIIMAPFGTPWKEHRKFTLVSL

REFGFGKRSLEGKIFEESVALQAEIIKMGNKPFDISRMVQNAVTNVICSIVFGSRFEYNDDKFIHLMENLNRLFATNLLS

QLAIFFPFLRRVPGMGRGPQDILDAVGTIQAYIREEIDSHRKTFDSNDIRDLIDSYVRETKSRENDDETTFTEEYTQWVI

FDLFIAGAETTSTTLYWAFLYIILNPDIQEKVQEEIHTVLGHDKPPSTAYRAQMPYTEAVLTEVARIGSVAPTSIVHATS

RDTSFHGYLIPEGTTVMPNLWSVHHDPEHFPNPLKFDPGRFLDAQGQYQRDDHVMPFGIGPRICLGKQLAEMELFVFFTS

LLQHFSFKLPEGAAKPSSTGINGITHSPKNFELVAEALV*

>e_gw.244.97.1|Brafl1

79% to e_gw.239.63.1|Brafl1

MILQTTLVLLAVFVVTRWYLSTPKNLPPGPRGWPVVGNIHSHCIRDILSATFGQDSRWLTETRCLTVTEWAKTYGPVYQM

RVGRQRVVVLNGYDVIYEALVKRAEDFSTRQFGPTTRIINPQQLGIIQAPFGTPWKEHRKFTLMSLREFGFGKRSLEGKI

LDESVALQTEIMKIGNGPFDIGRMIQNAVTNVICSIVFGSRWEYNDEKFTRLMDTLDRGFSFNFASQLAIFFPVLRFVPG

LGKGLDVARNVVDTIKSYIKEEIDDHKKTFVPNDIRDLIDSYIKEMKSRENEDETTFTDDYAEMVLFDLFIAGAETTSTT

LYWAFLHMILNPDIQAKVQEEIHSVLGHDKPPSTLHRAQMPYTEAVLTEVARIGTILPNSVIHATSHDTSFHGYHIPGNT

TVLPNIWSVHHDPQHFPNPGKFDPGRFLDAQGQYQRDDHVIPFSLGPRMCLGKQLAEMELFVFFTSLLQHFTFKLPEGAP

TPSTRGIHGITHSPKKYELIAEPLT*

>fgenesh2_pm.scaffold_106000005|Brafl1

78% to e_gw.239.63.1|Brafl1

MWFWKGREFCMREGNTPKNLPPGPRGWPVVGNMFSLTSETRCLTVTEWAKTYGPVYQMRVGRQRVVVLNGYDVIYEALVK

RAEDFSTRQFGPTTRIINPQQLGIIQAPFGTPWKEHRKFTLMSLREFGFGKRSLEGKILEESVALQTEIMKIGNGPFDIG

RMIQNAVTNVICSIVFGSRWEYNDEKFTRLMDTLDRGFSFNFASQLAIFFPVLRFVPGLGKGLDVARNVVDTIKSYIKEE

IDDHKKTFVPNDIRDLIDSYIKEMKSRENEEETTFTDDYAEMVLFDLFIAGAETTSTTLYWAFLHMILNPDIQAKVQAEI

HSVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTILPNSVIHATSRDTSFRGYHIPGNTTVLPNIWSVHHDPKHFPNPGKF

DPGRFLDAQGQYQRDDHVIPFSLGPRMCLGKQLAEMELFVFFTSLLQHFTFKLPEGAPTPSTRGIHGITHSPKKYELIAE

PLT*

>fgenesh2_pg.scaffold_41000078|Brafl1

82% to e_gw.239.63.1|Brafl1

MTEWAKSYGPVYRIQLGKETMIVLSGYDIIHEALTGIIMAPFGTPWKEHRKFTLVSLREFGFGKRSLEGKIFEESVALQA

EIIKMGNNPFDISRMVRNAVTNVICSLVFGSRFEYNDDKFIHLMENLNRLFATNLLSQLAIFFPFLRRVPGMGRGPQDIV

DAVGTIQAYIREEIDSHRKTFDYNDIRDLIDSYVRETKSRENDDETTFTEEYTQWVIFDLFIAGAETTSTTLYWAFLYII

LHPDIQAKVQEEIHTVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTILPTSVLHATSRDTSFHGYLIPEGTTVMPNLWSV

HHDPEHFPNPGKFDPCRFLDAQGQYQRDDHVMPFGIGPRICLGKQLAEMELFVFFTSLLQHFSFKLPEGAAKPSSTGING

ITHSPKNFELVAEALV*

>fgenesh2_pg.scaffold_106000121|Brafl1

76% to e_gw.239.63.1|Brafl1

MVVLSGYDIIHEALVKTADNFSSRPDNAIFKIINPQRLGIATAPFGTPWKEHRKFTLMSLREFGFGKRSMEGKILEESLA

FQAELMKMGNQPFDISRMIQNAVTNVICSIVFGYRFEYNDDKFIHLMDTFDRGFSFNFFTQLAVFFPILRHVPGLGRGPK

LIKEVLGTFRSFIKEELESHKKTFDPNDIRDLSDSYIKENKSRENDDETTFTDEYTECVLFDMFVAGTETTSTTMYWAFL

YIVLNPDIQRKVQEEIHTVFGHDKPPSTAYRAQMPYTEAVLTEVGRTATIAPTSVYRATTRDTRFHGYHIPEGATVAANL

WSVHYDPEHFPNPGKFDPGRFLDAQGQYRRDDHVIPFGLGPRMCLGKQLAEMELFLLITSLLQHFTFKLPEGADRPSTIG

FNGASHAAKKFKLVAEPLA*

>fgenesh2_pg.scaffold_114000008|Brafl1 green = 41% to CYP2U1 C-term

80% to e_gw.239.63.1|Brafl1

MTAFVLYPYKEVAGTGGTTEKGGDWTLPGINVINKDTVSFSHVFQPWDFDDFDKLATIPVGILARQIPTFSYLLGNRYFF

QPPEQNKNEPVFKLVFIRGQSFEFLPAYYRHLAPAPLCYRCGCRVYHVKTIPFCAGETSTWLPQLFYSVLRSSYHRYPHP

SQTSFACCSADHQTQVSPEHQSSNMKRAVGVGVPLGMILAVSAYLILTASNKNPLSKPGERVIKRSLALPDELQDALQAA

TAENPPAYVKDKRFLPAIANLAGNLLSSGGSFDAGKLTDTINQLGGMENMGPDIMAQSVKQEAEVTAEVEKEVAEETVDK

IFGQTEHDKKEEDGDGDDGGGGGDGQEHEIKAEVDFVAEKGMVEDDMFAPPGMQMKIDVEEDPQKDSEPDQSSQPMAFSY

PMGMGSALMNGCFGTGYKEGDPCWNKKDVIKNCWDMMEGCGYIGVGFDGRGDYSSTSRRKTVVQRNCENQATYHDEDVPD

TMNVHGIFDTEVASYVFESRQAYRHSLQMKAGMSFSGFGFQAAVEAAYGRETSSQKQSFMSLIQCNVIRYEIFLDEITPD

TLSLPFLRDFLSLPKNFIVGQAKLQKFIIRYGTHYIKSAKFGGSFRLFKTQEASKTGSIEDFSVQAQSSYNSLFFNAAGH

AGMGSSSESAQSSKTSNTHVTVEGGDQEVASIVADFYSTGFKDTFAEWLKSIPTYPKPIEMFMGTMSELLDLNYKLLFPF

DIKDAADGCFSEKYCDYTSVDKFQEGMDKKRLALERAIVMYMEEGPVPTTDFRLSGGEPGCTTEVLNVKGGASGTTYPTW

LELINGDTYKIIFDLPENINYDITKTTEAFLVYARGRWNCHKPGSKMHMYNSRNNGGSGDTSKRKVTCFGFVMTYDEATG

AFDVTPEDQEASKQILGNLPRNYANSNVARAEYVSPLEHSQENGRSLAGIVEAPCTVKWSNSYQIKPAEAGGRCLYFVAA

SSGDIFVVFSAIPRDKSTWYHLQISYQGVALYKGLKLVKYEGAKSARSLGDSKLFQPYFICLEEDHANQRTTIRYGIGSD

TSSPLGIRFYSFGSGEKDVEIMDARIIEGGAQGEMECTGGTILKDGKCVEDCHPECDGCIPISSGSKLDTECRRCKHFSY

DRGDGVIQCVAECPNDFEAGDDGKTCVCKGFLFPNDDGSSRCVPTCGTGFVPGPDGKTCAEVPKKWREDSRCGNGFPAPG

ANPAQCNPKSDRPCCSGGGWCGRTSTHCDCNTCKDYRNNVALKKPAYQSSTHESFGASKAVEGFTAGNFWAQTCTHTNTE

ANPTWWVDLGQTVNVASVSIYNRQDCCGERLNPFNVHIGDSSKVTDNPKCGGDHSASGQPTDISCSGMRGRYVGIRLPGN

SRTLTLCEVKVFLE FGFGKRSLEGKILEESVALQSDIMNMGKRPFDIRRMVQNAVTNVICSIVFGSRFEYNDDKLTRLMD

ALDEAFSTSIFNQLAIIFPILRRIPGLERGAQVKLDALCTIKTYIREEMNSHKETFDPNDIRDLIDSYVRETKSRENDDE

TTFTDEYTERVLFDLFIAGVETTSTTLYWAFLYMILNPDIQTKVQDEIHSVLGHDKPPSTAHRAQMPYTEAVLTEVARIS

TMSPTGIFHATSRDTSLHGYHIPEATTVLPNLWSVHHDPEHFPNPGKFDPGRFLDVQGQYRRDDHIMPFGIGPRMCLGKQ

LAEMELFLFFTSLLQHFTFNLPEGAAKPTTTGLNGLTHSPKNFKLVAETLV*

>fgenesh2_pm.scaffold_41000014|Brafl1

81% to e_gw.239.63.1|Brafl1

MHEALVKRGEDFSSRPDNPIVKLTNPNRIGIIWAPFGTPWKEHRKFTLMSLREFGFGKRSLEGKILEESVALQAEILKMR

NKPFDISRMIQNAVVNVICSIVFGCRFEYNDDKFTRLMDALDQVVSSNIFGQLAIFFPILRRVPGMGRGVQVIIDGVGNV

KAFIREEMSSHKKTFDSNDIRDLIDSYVRKTKSRENEDETTFTDEYTERALYDLFLAGSESTSTTLYWAFLHMILNPDIQ

KKAQEEIHSVLGHDKSPSTAHRAQMPYTEAVLTEVARIGTIAPTSFFHATSRDTSFRGYHIPEGMTVVQVDGGHLNTKKK

KNLLQVRACASGSSWQRWSSSCSSLPCFTFKLPEGAAKPTTTGINGITHSPKNFELVAEPLA*

>fgenesh2_pg.scaffold_457000007|Brafl1 36% to CYP2C9

81% to e_gw.239.63.1|Brafl1

MTEWAKTYGPVYRIQLGKETMIVLSEYDIIHEALVKRGEDFSSRSANNPLVKLTNPKRIGIIYAPFGTPWKEHRKFTLMS

LREFGFGKRSLEGNILEESVALQAEIMKMVNKPFDICRMVQNAVTNVICSIVFGSRFEYNDDKFKRLMDALNQVASTNIL

GQLAIFFPILRRFPGLGRGAQVIVDTVRTIKAYIREEMDSHKKTFDSNDIRDFIDSYVRETKSRENDDETTFTDEYTERT

NLWSVHHDPEHFPNPGKFDPGRFLDAQGQYQRDDHAMQFGIGPRMCLGKQLAEMELFVFFTSLLQHFTFKLSEGAANPST

TGINGITHSLKNFELVAGPLV*

>fgenesh2_pg.scaffold_114000062|Brafl1

87% to e_gw.239.63.1|Brafl1

MTEWAKTYGPVYRIQLGKETMVVLSGYDVMHEAFLKRGEDFSSRPFNPIVAIINPERLGILGAPFGTPWKEHRKFTLMSL

REFGFGKRSLEGKIMEESVALQAEIVKMGNKPFDINRMVQNAVTNVQEEIHSVLGHDKPPSTAHRAQMPYTEAVLTEVAR

IGTILPTSIFHATSRDTSLHGYDIPEGTTVMPNLWSVHHDPEHFPNPGKFDPGRFLDAQGQYQRDDHVMPFGIGPRMCLG

KQLAEMELFVFFTSLLQHFTFKLPEGAAKPSTTGINGITHSPKNFKLVAEPLA*

>fgenesh2_pg.scaffold_18000030|Brafl1 52% to CYP2U1

98% to fgenesh2_pg.scaffold_114000062|Brafl1

MPYTEAVLTEVARIGTILPTSIFHATSRDTSLHGYDIPEGTTVMPNLWSVHHDPEHFPNPGKFDPGRFLDAQGQYQRDDH

VMPFGIA

PVGVVLRTRQSVGPFFAPRKPKAGRLSKSVFGGGLEERVNGLARYVSSLNLSVTSLFSLESVVKLVAAPPRHT

HMRTPDPEVLSLRTGDETMRQTSSLIKPNS*

>e_gw.457.49.1|Brafl1

88% to fgenesh2_pg.scaffold_114000072|Brafl1

MSLREFGFGKRSLEGKILEESVALQAEILKMGNKPFDISRMVQNAVTNVICSIVFGSRFEYNDGKFTRLMDALDQAFSTN

IFGQLAIFFPILQRVPGMRRGPQIIVDAVGTIKTYIREEMDSHKETFDSNDIRDLIDSYVRETKSRENDDETTFTDEYTE

MVLFDLFIAGSETTSTTLYWAFMYMILNPDIQRKVQEEIYSVLGHDKPPSTAHRAQMPYTEAVLTEVARIGTIAPTSVFH

ATSRDTSFHGYHIPEGMTVVTNLWSVHHDPEHFPNPEKFAP

 

$$$$$$$$

 

>e_gw.110.123.1|Brafl1 45% to CYP2U1 fugu

SVWLGSRPAVVLSGQDAVKEALLKHGDVFSSRPDLFVWRRTIRTRGKGVATAPYGPEWKETRKVALTWLNTFGAGKQSLE

PTIVQEAQDLVQVFKDKRGQPFDPTVSLGLAVSNVICSVVFGRRFDHDDERFSRLMGLLNRYFQSNASSQALNVYPILRH

LPSFRRKLEEVVTFSEEMRSFVIDVIQEHRETFDPNNIRDVIDGFLLEEHRGNRILSEMPENNIFNVIRNLFLAGTDTTA

STLRWALLYLVMNPDVQQNVQEEIDESLGKQTPSMLLREHLPYTEATIREAQRIRTIVPLSAPHETTAPVTVLGHQIPAG

TFILPNLWSLHMDPKYWPDPERFDPTRFLDSDGQLVQRAESFLPFSTGMEVLTLCLGEQLAKFELFLFFTSLLQQFTFKL

PEGAPPPDTEGVFGLVFSPKPFKICAVPRF*

>e_gw.303.80.1|Brafl1

94% to e_gw.110.123.1|Brafl1

MSSLPSVWLGPRPAVVLSGQDAVKEALQKHGDVFSSRPDLFVWRRTIGTRGKGVVTAPYGPEWKETRKVALTWLNTFGAG

KQSLEPTIVQEAQDLVQVFKDKRGQPFDPTVSLGLSVSNVICSVVFGRRFDHDDDRFSRLMGLINRYLHTNTSSQALNIY

PILRHVPSFRRKLEEVVTCSDEIRSFVIDVIQEHRETFDPNNIRDVIDGFLLEEHQGNRILSELPENNIFNVIRNLFLAG

TDTTASTLRWALLYLVMNPDVQRKVQEEIDESLGKQTPSMLLREHLPYTEATIREAQRIRTIVPLSAPHETTAPATVLGH

QIPAGTFILPNLWSLHMDPKYWPDPERFDPTRFLDSDGQLVQRTESFLPFSTGMAVLTLCLGEQLAKFELFLFFTSLLQQ

FTFKLPEGAPPPDTEGIFGLVFSPKPFKICAVPRF*

>fgenesh2_pg.scaffold_110000031|Brafl1

90% to e_gw.110.123.1|Brafl1

MAVVQLTLENEYEGRSIELARTFGSNMGLFFVVLVLLGVYLYVQNLRLRRKYPPGPRAWPIVGNLRELARGQHRVFAEWR

LKYGDVFTVWLGPRPAVVLSGQDAVKESLLRHGDVFSSRPDLFVWRRTIGTRGKGIGTAPYGPEWKETRKVALTWLNTFG

AGKQSLEPTIVQEAQDLVQVFKDKRGQPFDPTVSLGLSVSNVICSVVFGRRFDHDDERFSRLMGLLNRYLSTNTSSQALN

IYPILRHVPSFRRKLEEVVTCSEEIRSFVIDVIQEHRETFDPNNIRDVIDGFLLEEHQGNRILSELPENNIFNVIRNLFL

AGTDTTATTLRWALLYLVMNPDVQRKVQEEIDVSLGKQAPSMLLREHLPYTEATIREALRIRTILPSSLPHETTAPVTIL

GHQIPAGTFILPNLWSLHMDPKYWLDPERFDPTRFLDSDGHLAQRTESFLPFGTGPRRCLGEQLAKFELFLFFTSLLQQF

TFKLPEGAPSPDTEGIFGLVFSPKPFEICALPRF*

>fgenesh2_pg.scaffold_110000030|Brafl1

88% to e_gw.110.123.1|Brafl1

MGLFFVVLVLLGVYLYVQNLRLRRKYPPGPRAWPIVGNLRDLARGQHRVFAEWRLKYGDVFTVWLGPRPAVVLSGQDAVK

EALQKHGDVFSSRPDLFVWRRTIGTRGKGVVTAPYGPEWKETRKVALTWLNTFGAGKQSLEPTIVQEAQDLVQVFKDKRG

QPFDPTVSLGLSVSNVICSVVFGRRFDHDDDRFSRLMGLINRYLHTNTSSQALNIYPILRHVPSFRRKLEEVVTCSDEIR

SFVIDVIQEHRETFDPNNIRDVIDGFLLEEHQGNRILSELPENNIFNVIRNLFLAGTDTTASTLRWALLYLVMNPDVQRK

VQEEIDESLGKQTPSMLLREHLPYTEATIREAQRIRTIVPLSAPHETTAPVTVLGHQIPAGTFILPNLWSLHMDPKYWPD

PERFDPTRFLDSDGPRRCLGEQLAKFELFLFFTSLLQQFTFKLPEGAPPPDTEGIFGLVLSPKPFKICAVPRF*

>e_gw.303.81.1|Brafl1

87% to e_gw.110.123.1|Brafl1

MELFFVALVLLGVYLYVQNLRLKRKYPPGPRAWPIVGNLRELARGQQRVFAECRLKYGDVFTVWLGPRPAVVLSGQDAVK

EALQKHGDVFSSRPDLFLSPFSLSSGVVTAPYGPEWKETRKVALTWLNTFGAGKQSLEPTIVQEAQDLVQVFKDKRGQPF

DPTVSLGLSVSNVICSVVFGRRFDHDDERFSRLMGLINRYLHTNTSSQALNIYPILRHVPSFRRKLKEVVTCSDDVRSFV

IEVIQEHRETFDPNNIRDVIDGFLLEEHRGNRILSELPENNIFNVIRNLFLAGTDTTATTLRWALLYLVMNPNVQQKVQE

EIDESLGKQAPSMLLREHLPYTEATIREAQRIRTILPSSLPHETTAPVTILGHQIPAGTFILPNLWSLHMDPKYWPDPER

FDPTRFLDSDGQLAQRTESFLPFGTGPRRCLGEQLAKFELFLFFTSMLQQFTFKLPEGAPTPDTEGIFGLVFSPKPFEIC

ALPRF*

>e_gw.303.76.1|Brafl1

88% to e_gw.110.123.1|Brafl1

MSSFCSVWLGSRPAVVLSGQDAVKEALLKHGNVFSSRPDLFVWRRTIPTRGKGVVTAPYGPEWKETRKVALTWLNTFGAG

KQSLEPTIVQEAQDLVQVFKDKCGQPFDPTVSLGLSVSNVICSVVFGRRFDHDDKRFSHLVGLLNRYLGSSASSQALNIY

PKLWHVPSFRRKLGEVVTFSEEIRSFVIEVIREHRETFDPNNIRDVIDGYLLEEHRGNRILSELPQDNIINVIKNLFAAG

TDTTATTLRWALLYLVMNPDVQGKVQEEIDESLGKQTPSILLREHLPYTEATIREAQRIRTIVPSSVPHETTAPATILGH

QIPTGTFILPNLWSLHMDPKYWPDPERFDPTRFLDSDGQLRQGTESFLPFSTGPRRCLGEQLAKFELFLFFTSLMQQFTF

KLPEGVPTPDTEGIFGLVFSPKPFEICAFPRF*

>fgenesh2_pg.scaffold_52000076|Brafl1

88% to e_gw.110.123.1|Brafl1

MELFFVALVLLGVYLYVQNLRLTRKYPPGPRAWPIVGNLRDLARGQHRVFAEWRLKYGDVFTVWLGSRPAVVLSGQNAVK

EALLKHVFSSRPDFTMFLIVMFFFIVRLLNDLTCISGVPKHLHEPYEIRVVTAPYGPEWKETRKVALTWLNTFGAGKQSL

EPTIVQEAQDLVQVLKDKRGQPFDPTVSLGLAVSNVICSVVFGRRFDHDDGRFTRLMGLLNRYFGSSASSQALNIYPILR

HVPSFRRKLEEVVTFSDEIRSFVIEVIQEHRETFDPNNIRDVIDGFLLEEHRGNRILSQLPQDNIINVIKNLFAAGTDTT

ATTLRWALLYMVMNPDVQEKVQKEIDDSLGKQTPSMLLREHLPYTEATIREVQRIRTIVPSSVPHETTAPAIILGHQIPA

GTFIIPNLWSLHVDPKYWPDPERFDPTRFLDSDGHLAQGTESFLPFSTGPRRCLGEQLAKFELFLFFTSLLQQFTFKLPE

GAPPPDTEGIFGLVFSPKPFEICALPRF*

>e_gw.110.18.1|Brafl1

84% to e_gw.110.123.1|Brafl1

MELFFVALVLLGVYLYVQNFRLTRKYPPGPRAWPIVGNLRELARGQHRVFAEWRLKYGDVFTVWLGPRPAVVLSGQDVVK

EALQKHGDVFSSRPDLDLMKCCDRPVKIIRSARAGLTAAAYGPEWKETRKVALTWLNTLGAGKTSLEPTIVQEAQDLVQV

FKDKCGQPFDPTVSLSLAVANVICSVVFGRRFDHSDERFSRLVELQNRRLVLTSQALNVYPILRHVPSFRRKLEEVLTCS

EEIRSFVIDVIQEHRETFDPNNIRDVIDGFLLEEHRGRNRILSDLPQDNIINVIRNLFVAGTDTTATTLRWALLYLVMNP

DVQRKVQEEIDVSLGKQTPSMLLREHLPYTEATIREAQRIRTISPSSVPHETTAPATILGHQIPAGTFILPNLWSLHMDP

KYWPDPERFDPTRFLDSDGHLAQRTESFLPFGTGPRRCLGEQLAKFELFLFFTSLLQQFTFKLPEGAPSPDTEGIFGLVF

SPKPFEICALPRF*

>fgenesh2_pm.scaffold_110000006|Brafl1

80% to e_gw.110.123.1|Brafl1

MGLFFVALVLLGVYLYVQNLQLTRRYPPGPRAWPIVGNLRDLARGQHRVFAEWRLKYGDVFTVWLGPRPAVVLSGQAAVK

EALQKHGDVFSSLKQRFRGYLPIRSTSLTAAAYGPEWKETRKVALTWLNTFGAGKQSLEPTIVQEAQDLVQVFKDKCGQP

FDPTVSLSLAVANVICSVVFGRRFDHSDERFSSLVELQNRYEDFWFLLQALNVYPILRHVPSFRRKLEEVVTCSDEIRSF

VIEVIQEHRETFDPNYIRDVIDGFLLEEHRGNRILSELPQDNIINVIRNLFVAGTDTTATTLRWALLYLVMNPDVQRKVQ

EEIDESVGKQAPSMLLGEHLPYTEATIREAQRIRPIAPSSVPHETTAPATIMAHQIPAGTFIIPNLWSLHMDPKCWPDPE

RFDPTRFLDANGQLKTSVESFLPFCTGPRRCLGEQLAKFELFLFFTSMLQQFTFMLPEGAPTPDTEGIFGLVFSPQPFKI

CAFPRF*

>e_gw.303.46.1|Brafl1

88% to e_gw.110.123.1|Brafl1

PFDPTVSLGLSVSNVICSVVFGRRFDHGDERFSRLMGLLNRYLSTNTSSQVCALNIYPILRHVPSFRRKLEEVVTCSDEI

RSFVIDVIQEHRETFDPNNIRDVIDGFLLEEHQGNRILSELPENNIFNVIRNLFLAGTDTTASTLRWALLYLVMNPDVQR

KVQEEIDVSLGKQTPSILLREHLPYTEATIREAQRIRSIAPSSVPHETTAPATVLGHQIPTGTFILPNLWSLHMDPKYWP

DPERFDPTRFLDSDGQLKQGTESFLPFSTGPRRCLGEQLAKFELFLFFTSLMQQFTFKLPEGAPTPDTEGIFGLVFSPKP

FEICAFPRF*

>fgenesh2_pg.scaffold_303000063|Brafl1

80% to e_gw.110.123.1|Brafl1

LTAAAYGPEWKETRKVALTWLNTFGAGKQSLEPTIVQEAQDLVQVFKDKCGQPFDPTVSLSLAVANVICSVVFGRRFDHS

DERFSSLVELQNRYFRANASAQALNVYPILRHVPSFRRKLEEVVTVL

(gap_

GNRILSELPQDNTINVIRNLFVAGTDTTASTLR

WAMLYLVMHPDVQRKTPSTLLREHLPYTEAAIREAQRIRPIAPSSVPHETTAPATIMGHQIPAGTFIIPNLWSLHMDPKY

WPDPERFDPTRFLDANGQLKTSMESFLPFCTGPRRCLGEQLAKFELFLFFTSMLQQFTFKLPEGAPTPDKEGIFGLVFSP

QPFKIRAFPRF*

 

 

$$$$$$$

 

>fgenesh2_pm.scaffold_67000004|Brafl1

MAGAVQWIAESVHEILQAPGLTLQTFVIFCLAFLLTCTLLRRSQNLPPYPAGRVPVLGHLLALGRAPHLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPRIYMLDSIAGDGKDMVAARWGPGFRQRKRFATIALKNLGMKVGRG

SIEDNIREEANCLRSRVAEYEGQPFDFAHDVTVTVANVICSMVFGKRYDYEDETFQELSKAVTAVVTELPPAKSSASSRP

CVNRAGTDLLQHVSKIHQVMWEEISRRREHLHRENPRDFLDFCLLEIDQQDKVEGLTEENVMYMAMNLFLAGTETTGNTL

LWALLYLTQNPAIQHKVHEELDAVVGASLPTLSHRSRLPYVNACLLETMRIRTLVPLAIPHSTTQDVKVQKFDIPKGTQV

LPNLHSLHTDPAYWPDPDRFDPERFLDAEGNIINKPQSFMPFGGGRRVCLGEQLARMELFLFFSCLLQSFTFNTPEGAPP

PNTDGILGITWTPNPYQLCATPR*

>fgenesh2_pg.scaffold_838000001|Brafl1 36% to CYP2P9

81% to fgenesh2_pm.scaffold_67000004|Brafl1

MTLQTFLVFCAAFLLANVLLKRSRNLPPYPAGCVPVLGHFLALGRAPPLKLAAWRRQYGDVFTVRLGMEDVVVLNGYTAI

KDALVDRSELFASRPQVYFLDLITDMAAVRWGPGFRQRKRFAYTVLKNLGMKVGRGSMEGHIREEANCLCSRMAEYKGQP

FDFAHDVTVTFANVICSMLFGKRYDYGDETFQELKKAIDAVVIGLAAGQVISVFPFLRFVPG

(Gap)

GRNPRDFLDFCLLEVDQQ

DKVDGLTEENVMYMAMNLILAGTETTAGTLLWALLYITQNPAIQQKVHEELDAVIGVSLPTLFHRSQLPYVNACLLETMR

IRTVVPFALPHATTQDVKVREFHIPKGTQVILNLYSLHVDPTYWPDPERFDPERFLDAEGNVINKPESFMPFAGGRRVCL

GEKLARMELFLFFSTLLQSFTFRTPEGTPPPNTDYVLGLTWSPRPFQVCATPR*

>fgenesh2_pg.scaffold_537000017|Brafl1

74% to fgenesh2_pm.scaffold_67000004|Brafl1

MAGTAQWVAESVQEILQISGLTLQTFLVFCATFLLACVIFKRSQNLPPYPAGRVPVLGHLLALGRAPLCKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRLPVYLLDAMSGFGKDNVAASWSPGYRQRKRFATTVLKNLGMKVGRG

SIEDNIREEAICLRSRIAENNGQPFDIGHDVTVAVANVICSMVFGKRYDYEDETFRELSKAIVTLFSALGQGQIIAVLPL

LRLVPVVNKAFNNAWGEYVKLRNVCREEISRHQERLDRENPRDFIDFCLLEVEQQEKVDGLTEENVLYMTGNLFMAGTDT

TINTLLWSLLYMTLNPDIQNKVREQLDAVVGESLPTLSHRSRLPYVNACLLETMRIRTLLQLSMRSLMPLLVRVHPVPPS

PAALRERLPAGDHEDPHPSSIVIGDACPHRSMRSLMPLLVQQELDAAVGESQPALSHRSQLPYVNACLLETMRIRTPAPI

AGHATTQEVKVQGYDIPEGTKVLMNLHSLHMDPAYWPDPDRFDPERLLDVEGNVINKPESFMPFGGGRRGCLGDQLARME

LFLFFTTLLQSFTFKAPEGAPPPNTDGVLGLMLKPHPFQLCAIPR*

>fgenesh2_pg.scaffold_21000014|Brafl1 40% to CYP2Y3

96% to fgenesh2_pg.scaffold_537000017|Brafl1

MAGTAQWVAESVPEILQISGLTLQTFLVFCATFFLACVIFKRSQNLPPYPAGRVPVLGHLLALGRAPLRKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRLPVYLLDAMSGFG KDDYVSPEVASPEVASPEVASPEVVPQEARDTI

ADEVNKLREMLQEMPRIIPVSAAGPATGWTRWYDRDNPSASGDWETLSTLRRENPGKICAAPSGIQARVKGTNRPASLNG

DRFFQFNPQQGIVCRNADQCHGRCHDYEVRFWCP*

>fgenesh2_pg.scaffold_97000131|Brafl1

78% to fgenesh2_pm.scaffold_67000004|Brafl1

MAGAVQWIVQISWLTPQTILVLCTTFLLACAVFKRSRNLPPYPAGRVPVLGHLLALGRAPHLQLTAWRRQHGDVFTVRMG

MEDVVVLNGYTAVKDALVDRSELFASRPSVYLLDTFGKEKDIASGRWGTGFRQRKRFATAVLKNLGMKVGRGSIEEKIAE

EAKFLHNRVAKYEGAPFDFAHDVTVTVANVICSMMFGKRYDYEDDAFRVLSEAVTAVATELAAGQIISVFPSLRFVPGVN

RAGTNLVEHVSKLQRVLWEEISRHREHLDRENPRDFLDFGLLEVEQQEKVDGLTEEIVIYLTQNLFVAGTETTANTLLWG

LLYLTQNPAIQHKVHEELDAVVGASLPALSHRSQLPYVNACLMETMRIRTIVPFAIPHATTQDVKVQQFDIPKGTQVLPN

LYSLHMDPTYWPDPDRFDPERFLDAEGKLINKPESFLPFGGGRRVCPGEQLARMELFLFFSTLLQSFTFKTPEGAPPPNT

DGILGITLTPHPFQLCAIPR*

>e_gw.378.88.1|Brafl1

69% to fgenesh2_pm.scaffold_67000004|Brafl1

FKQRKRFVTATLKNLGMKVGQDSIEEDIREEASFLRNRITEYEARPFDPAHDVTVAIANVICSMVFGRRYDYEDETFREL

TEGIGAVVADHGAGQIISVFPFLRFVPGGQYKSVSAHIAKIQKMEKEEISRHREHLDSENPRDFLDFCLLELEQQDKLEG

LTEEHVLYMAQDIFFAGTDTTSNTLLWSLLYMTLNPDIQNKVHEELDAVVGESLPALSHRSQLPYVNACLQEVMRIRPVG

PLAIPHATTEAVRVGEYDLPKGTQVLLNLYSLHMDPAYWPDPDRFDPERFLDAEGKVINKPESYLPFGGGRRGCLGEQLA

RMELFLFFTALLQSFTFKAPDCAPPPNADGILGLTLTPHPFQLCAIPR*

>e_gw.636.17.1|Brafl1 505 to CYP2U1

95% to e_gw.378.88.1|Brafl1

MEKEEISRHRAHLDRENPRDFLDFCLLELEQQDKLEGLTEEHVLYMAQDIFFAGTDTTSNTLLWSLLYMTLNPDIQHKVH

EELDAVVGESLPTLSHRSQLPYVNACLQEVMRIRPVGPLAIPHATTEAVRVGEYDLPKGTQVLPNLYSLHMDPAYWPYPD

RFDPERFLDAEGKVINKPESYLPFGGGRRGCLGEQLARMELFLFFTTLLQSFTFKPPEGAPSPNADGILGLTLTPHPFQL

CAIPR*

>estExt_fgenesh2_pg.C_1280113|Brafl1 35% to CYP2N13, 33% to CYP2B6

67% to fgenesh2_pm.scaffold_67000004|Brafl1

MAVIVSWIAELVWEIFQISGLTIQTFLVFCVVFLLAYVLLKRHKNLPPYPAGRVPVLGHLLALGREPPLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPNYLLDAIVGCGKEIVSARWGPEFKQRRKFATAALKNLGMKVGTG

SIEESIREEANCLRNRIAEYEGQAFNISSDLGVSVGNITCSMAFGKRYDYGDETFCGLLEAVMNVIAELGAGQIISVFPL

LRFVPGINRAFMEVLKQNSKIHEVLWDEIARHRENFDNENPRDFIDFCLLELEQ

 

QEKVHEVLDTVVGKSLPALSHRSQLP

YVNACLMETMRIRHIAPLIIPHATTDTVRVQEYDIPEGTL

 

THGKSHHVGHMGGHPVAGMGPTNTCPGGRGGTLQIDVNPT

SLPFRDTKTFIAGSLHQNVDVLMNMYSLHMDPVY

 

WPDPDRFDPERFLDAEGNVINKPESFMPFGGGRRVCLGEQLARMEL

FLFFSTLLQSFTFKTPEGAPAPCADGIFRMTLTPHPFELCAIPR

 

STQPTTHPTMASVEGVTIRPAVFEDKDKIIQIDVAE

EDLKNKEFDDIKDDLEDEDDFDDDESYMFVAETETEVIGFAMLGDVDKGGRGGLICDMRVDKAWREAGVYEMMYDYVIDY

AKNETGMKYIRTTVNKFPEGTNVKEIATLKYIAFEGEAETLRESLKSVPAMEELPLDTVVEYKQRHMRLMLRPGVGENVL

TQGLFFADGDSFTLCKDNLYDLDEENDVYVDNNKPIQSISFGTDFECDRATFYDIEVNCKDIRLMKSHILKQMQTACVTA

EGQVVFSVLALDYEDEIREFCKGIEGLEEVEQFNETVVWSKIVLYSD*

>e_gw.97.233.1|Brafl1 92% to estExt_fgenesh2_pg.C_1280113|Brafl1

70% to fgenesh2_pm.scaffold_67000004|Brafl1

IVSARWGPEYKQRRKFATAALKNLGMKVGTGSIEESIREEANCLRNRIAEYEGQPFNISSDLGVSVANITCSMAFGKRYD

YEDETFCGLLEAVMNVIAELGAGQIISVFPLLRFVPGTFMEVLKQNSRVHEVLWDEIARHRETFDSENPRDFIDFCLLEL

EQQEKVDGLTEENVMYMAQDLFFAGTETATNTLLWSLLYMTLNPGVQQKVHEELDTVVGASLPTLSHRSRLPYANACLME

TMRIRHIAPLIIPHATTDTVRVQEYDIPEGTQVLMNMYSLHMDPAYWPDPDRFDPERFLDAEGNVINKPESFMPFGGGRR

VCLGEQLARMELFLFFSTLLQSFSFKTPEGAPAPCADGIFRMTLTPHPFELCAIPR*

>e_gw.24.400.1|Brafl1

71% to fgenesh2_pm.scaffold_67000004|Brafl1

MFFVPVEVVTARWGTGFRQRKRFVTTALKNLGMKVGRGSIEEKIREEANILRNRIAVYNGQPFDIAHDVIVAVANIICSM

VFGKRYDYEDETFRELLEAIVTVTFEIGSAQIISVFPFLRFVPIGRAGNNALEETLKVQNVVREEISRHREHLDRENPRD

FLDYCLLEVEQQEKVDGLTEENVRYMAGNLFFAGTETTTNTLLWSLLYMTLNPDIQLKVHEELDAVIGESLPALSHRSQL

HYVNACLLEVMRIRSLLPVAIPHATTREVKVKEYDIPKGTQVLMNLHSLHTDPLYWPDPDRFDPERFLDTDGSFVNKPES

FLPFSGGRRVCPGEQLARMELFLFFSTLLQSFIFKTPEGASPPDTDGVFGLTLTPPPFQLCAIPR*

>e_gw.24.403.1|Brafl1 46% to CYP2U1

92% to e_gw.24.400.1|Brafl1

PFDIAHDVNVAVANIICSMVFGKRYDYEDETFQQLLEAIITVTFEIGSAQIISVFPFLRFVPIAGVNALEEDLKVQNVLR

EEISRHREHLDRENPRDFLDFCLLEVEQQGKVDGLTEENVLYMAGNLFFAGTDTTTNTLLWSLLYMTLNPDIQHKVQEEL

DAVVGASLPALSHRSQLPYVNACLLEVMRIRSLLPVAIPHATTREVKVQEYDIPKGTQVLVNLHSLHMDPVYWPDPDRFD

PERFLDKDGNVVNKPESFLPFSGGRRVCPGEQLARMELFLFFSTLLQSFIFKTPEDASPPDTDGVFGLTLTPPPFQLCAIPR*

>estExt_gwp.C_2420004|Brafl1

86% to fgenesh2_pm.scaffold_67000004|Brafl1

MCQLFQVAEYEGKPFDFAHDVTVTVANVICSMVFGKRYDYEDETFQELAEAVTAVATELAAGQIISVFPVLRFVPGGKLA

GTDLFQHVSKIHHVMWEEISRRREHLHRENPRDFLDFCLLEIDQRDKVEGLTEENVMYMATNLLLAGTETTGNTLLWALL

YMTQNPTIQHKVHEELDAVVGESLPTLSHRSQLPYVNACLLETMRIRTLVPLAVPHATTQDVKIQEFDIPQGTQVLPNLY

SLHMDPTYWPDPDRFDPERFLDAEGNVINKPQSFMPFGGGRRVCLGEQLARMELFLFFSTLLQSFTFKTPEGAPPPNTDG

VLGITWTPNPFQLCATPR*

>e_gw.3.158.1|Brafl1

70% to fgenesh2_pm.scaffold_67000004|Brafl1

RQYGDVFTLRMGMEDEVFLNGYTAVKDALVDRSELFASTIPGYLLDVLVGFGKGILGAPWGPGYRQRKRFATTVLKNLGM

KVGRGSIEDNIREEASCLRNKIAESNGQPVDIAHDVSVAVSNIICSMTVGKRYDYEDETFRELYKAIAAITFEVGTGRII

GAFPLLRFVPVGRSNSSFEQYFAQLTWIELLISRHREHLDRENPRDFIDFCLLEVEQQEKVDGLTEENVLHVTTELFFAG

TETTTNTLLWSLLFMTLNPDVQNKVQQELDAVVGESLPALSHRSQLSYVNTCLLEVMRIRTLVPIAAHATAEDVKVQGYD

IPKGTQVLVNLHSLHMDPVYWPDPDRFDPERFLDAEGNVVNKPQSFMPFAGGRRVCPGEQLARMELFLFFSTLLQSFTFI

TPEGAPAPNTDGIFRLTLKPHPFQLCAIRR*

>estExt_fgenesh2_pg.C_30188|Brafl1

MAEGGLRYKDKVVIVTGGSKGIGEGAVRAFVKDGGSKVVFCSRGEEAGKKLESEMNTSGPGEALFIPCDVTKEEDIRNVI

DKTVEKYGRIDCLINNAGMHPPEQTIDDTSVEEFRSLLNLNLVSYFIASKFALPHLRKTQGNIINMSSLVGIIGQTHACA

YVTTKGGITSLTRALAVDEAKYGVRVNTVSPGNIWTPMWDGLSKASGNTEAMVKGGEEAQLLGRMGTIEEAGKVCLFLAA

EATFSTGRVPVFGHLRALGGTPL

37% to 2K22

96% to e_gw.3.158.1

LKMAAWRRQYGDVFTLRMGMEDEVVLNGYTAVKDALVDRSELFASTIPGYLLDVLVG

FGKGILGAPWGPGYRQRKRFATTVLKNLGM

(gap) 45% to CYP2K19

KVGQSNGQPVDIAHDVSVAVSNIICSMTVGKRYDYEDETFRELYKAIAAI

TFEVGTGRIIGAFPLLRFVP

(gap) 37% to CYP2K16

VELEQQEKVDGLTVENVLHMTTELFFAGTETTTNTLLWSLLFMTLNPDVQNKVQEELDAV

VGTSLPALSHRSQLTYVNACLLETMKIRTLLQLH

(gap) 61% to CYP2K19

VLFSGRRVCPGEQLARMELFLFFSTLLQSFTFITPEGAPAPNTDGI

FRLTLKPHPFQLCAIRR*

>fgenesh2_pg.scaffold_814000010|Brafl1 38% to CYP2AA6

70% to fgenesh2_pm.scaffold_67000004|Brafl1

MGMKDAVVLNGYTAVKDALVDRSELFASRPPNYLFDLTVDFGKDISAARWGTQFKQRKKFALTALKNLGMKVGNGSIQES

IREEASNLRNRIAEYEGQPFDIAHDVTVTVANVICSMTFGKRYDFEDETFRELSEAIFTVMAEVGAGQIVSVFPLLRFVP

VVNRASVSVSRQIAKIQKVLKEEMARHRQHLDRENPRDFLDFCLLELEQQEKSLTEENVLYIAQNLFLGGTDTTTHTLLW

SLLYMTLNPEVQNKVHEELDAVVGESLPALSHRSQLPYVNACLMEIMRIRYVGPLSVPHATTAPVKVQEYDIPKGTQVIV

NLHSLHVDPAYWPDPDRFDPDRFLDAEGNFINKPESFMPFSAGRRVCLGEQLARMELFLFFSTLLQSFTFKPIEGAPPPS

TKGVFGLTLTPHPFQLCAIPR*

>e_gw.40.110.1|Brafl1 46% to CYP2U1

96% to fgenesh2_pg.scaffold_814000010|Brafl1

EPFDIAHDVTVTVANVICSMTFGKRYDYEDETFRELSEAIFTVMAEVGAGQIVSVFPLLRFVPVGDVSVSRQIAKIQKVL

KEEMARHREHLDRENPRDFLDFCLLELEQQKKSLTEENVLYIAQNLFLGGTDTTTHTLLWSLLYMTLNSEVQNKVHEELD

AVVGESLPALSHRSQMPYVNACLMEVMRIRYVGPLSVPHATTAPVKVQEYDIPKGTQVIVNLHSLHVDPAYWPDPDRFDP

DRFLDAEGNFINKPESFMPFSAGRRVCLGEQLARMELFLFFSTLLQSFTFKPIEGAPPPSTKGVFGLTLTPHPFQLCAIPR*

>e_gw.303.105.1|Brafl1

78% to fgenesh2_pm.scaffold_67000004|Brafl1

MAAVRWGPGFRQRKRFAYTVLKNLGMKVGRGSMEGHIREEANCLCSRMAEYKGQPFDFAHDVTVTFANVICSMLFGKRYD

YGDETFQELKKAIDAVVIGLAAGQVISVFPFLRFVPGGKLVATDMFQHVLKLHHVLWEEISRHREHLDRKNPRDFLDFCL

LEVDQQDKVEGLTEENVMYMAMNLILAGTETTAGTLLWALLYITQNPAIQQKVHEELDAVIGVSLPTLSHRPQLPYVNAC

LLETMRIRTVVPFALPHATTQDVKVREFHIPKGTQVILNLYSLHVDPTYWPDPERFDPERFLDAEGNIINKPESFMPFGG

GRRVCLGEKLARMELFLFFSTLLQSFTFRTPEGTPPPNTDYVLGLTWSPRPFQVCATPR*

>e_gw.636.5.1|Brafl1

71% to fgenesh2_pm.scaffold_67000004|Brafl1

APHLKLTAWRRQYGDVFTVRMGMKDAVVLNGYTAVKDALVDRSELFASRPPNYLPILTFFVPEDIASVSWGTELKQRKRF

ATAALKNLGMKVGTGSIEEDIRQEASFLRNRIAGYKEKPIDTAHDVNVAVANIICSMVFGRRYDYEDETFRELTEAIVTV

LAELGAGQIISVFPFLRFVPGASLCVSAQVAKIQKVVKEEISRHREHLDRENPRDFLDFCLLELEQQEKVDGLTEEHIMY

IAQELFFAATDTTSNTLLWSLLYMTLNPDIQNKVHEELDAVVGESLPTLSHRSLLPYVNACLQEVMRIRPVGPLAIPHAT

TEAVRVRGYDIPKRTQVLLNLYSLHMDPAYWPDPDRCDPERFLDAEGNVINKPESFMPFGGGGRVCLGEQLARIELFLFF

STLLQSFTFKTPEGAPPPNADGILGLTLAPHPFQLCAIPR*

>e_gw.378.34.1|Brafl1 47% to CYP2U1

93% to e_gw.378.34.1

PIDPAHDVTVAVANIICSMVFGRRYDYEDETFRELTEAIVTVLAELGAGQIISVFPFLRFVPGGNLCVSAQVAKIQKVVK

EEISRHREHLDRENPRDFLDFCLLELELQEKLEGLTEEHVLYISQELFFAGTDTTANTLLWSLLYMTLNPDIQNKVHEEL

DAVVGESLPTLSHRSQLPYVNACLQEVMRIRPVGPLAIPHATTEAVKVRGYDIPKRTQVLLNLYSLHMDPAYWPDPDRFD

PERFLDAEGKVINKPESFLPFGGGGRVCLGEQLARMELFLFFTTLLQSFTFKPPEGASPPNADGILGLTLAPHPFQLSAI

PR*

>e_gw.41.8.1|Brafl1 40% to CYP2U1

68% to fgenesh2_pm.scaffold_67000004|Brafl1

MPVLGHLLALDDKAPHLTLTAWRRQYGDVFTIKLGMEDAVVLNGYTAVKDALVDRTELFASRPPRYMFDVLVGFGKDIAA

ARWGPAFRQRKRFATAVLKNLGMKVGRGSMEDGIREEARYLCNRVRGNNGSPFGDIEHDVTVAVANIICSMAFGKRYDYE

DETFKELYGAIATIAFQLSTARLLGVFPFLRFVPIGRAGTNAWEAYDKVKKVLREEISRHRDRLDRENPRDFLEFCLLEL

ERQEKVDGLTEENVLYLTGDLFLAGTETTTNTLLWSLLFMTLYPDVQTKVHDEIDAVVGENMPALSHRSQLPYVNAYLME

VMRFRTLGPVLSHATTQDVKVQGYDIPNGTRVLVNLHSVHVDPAYWPDPDRFDPERFLDAEGNVINHPESFIPFGGGRRV

CLGEQLARMELFLFFSTLLKCFTFKTPEGAPPASTDGVLGLTIAPHESQLCAIQR*

>e_gw.60.9.1|Brafl1

73% to fgenesh2_pm.scaffold_67000004|Brafl1

LAAWRRQYGDVFTVRLGMTDAVVLNGYTAVKDALVDRSELFACRAPPYLLDAMVGFGQDILFARWGPGFRQRKRFATAVL

RKLGMKVGRGSIEDNIREEANCLRNRIAENNGQPFDIAHDVTVGVANIICSMVFGKRYDYEDETFRELSESLPVLSFAFG

TGRIIRAFPLLRFVPVGRPAVNAWEAHSKVVSVITEEISRHRERLDRENPRDFLDFCLLEQQAKLSSLTEENVLHMAGDL

FLAGTETTTNTLQWSLLYMTLNPDIQNKVQEELDAVVAESLPTLSHRSQLPYVNACLLEVMRIRTLIPAVRHVTTQEVKV

QEYHISMGTWVLANLHSLHTDPAYWPDPDRFDPERFLDAEGNVINNPKSFMPFGGGRRACLGEQLARMELFLFFSTLLQS

FTFTTPEGALPPNTDGVFGLTLVPHPFQLCATPR*

>e_gw.88.43.1|Brafl1

71% to fgenesh2_pm.scaffold_67000004|Brafl1

YGDVFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPNYLFDSSVGFGKDIGAARWGTGLKQRRRFATAALKHLGMKV

GTGSVEDNIRQEASCARPTYNLQIAEYHGQPFAISNDMKVAVANVICSMAFGRRYGYEDETFRELSEAIRNLLAEIGSGQ

FISVFPLLRFVPGGEACKEVLKHLSKIHEVLWDEIARHRENFDRENPRDFLDFCLLELEQREKVEGLTEENVLYMAQNLF

LAGTDTTANTLLWSLLYMTLNPDIQNKVHEELDAVLGVPALSHRSQLPYVNACLLETLRIRTILPFAVPHATTKAVRTQG

FDIPRGTQVLPNLYSLHMDPAFWPDPDRFDPGRFLDAEGNLINKPQSFMPFSGGRRVCLGEQLARMELFLFFSTLLQSFN

FKTPEGAPAPNTDGVLGLTLVPHPFQLCAMPR*

>estExt_gwp.C_970192|Brafl1

75% to fgenesh2_pm.scaffold_67000004|Brafl1

MGMKDVVVLNGYTAVKDALVDRSELFASKSPNYLFDAIFGFGKDILAARWGPGFRQRKRFATTVLKNLGIKVGRGSIEDN

IREEANCLRNRIAANNGQAFDIAHDVTVAVANIICSKAFGKRYDYEDETFRELSEAITAVSSEVGTGRIIAVFALLRFVP

VAIIKALEANSKVKSVLREEISRHREHLDRENPQDFLDFCLLELEQQEKVAGLTEENIMYMTSNLFLAGTETTTNTLLWS

LLYMTLNPDVQNKVHEELDAVVGESLPTLSHRSQLPYVNACLMETMRIRTLVPLVAHATAQEVKVQGYDIPQGTQVLFNL

YSLHMDPAYWPDPDRFDPERFLDAEGNVINKPESFMPFGGGRRVCLGEQLARMELFLFFSTLLQSFTFKTPEGAPPPNTD

GIFRLTLKPHPFQLCAIRR*

>fgenesh2_pg.scaffold_3000199|Brafl1 52% to CYP2U1

85% to estExt_gwp.C_970192|Brafl1

MVNLHSLHMDPAYWTDPDWFDLGRFLDAEGNVINKPQSFMPFGGGRRVCLGELVARMELFLFLSTLLQSFTFRTPEGAPP

PNTDGIIRLTVKPHLFQLCAIRR*

>e_gw.94.46.1|Brafl1 49% to CYP2U1

86% to estExt_gwp.C_970192|Brafl1

DNTLLWSLLYMTLNPDIQNKVHEELDAVVGASLPTLSHRPQLPYVNACLLEVMRIRTLLPIVRHATTQEVKVQGYDIPKG

NPVLMNLYSLHMDPAYWPDPDRFDPERFLDAEGNLINKPESFMPFGGGRRMCLAEQLARMELFLFFSTLLQSFTFKTPEG

APPPNTVGVLGTTLTPHHFKLCATQR*

>e_gw.419.24.1|Brafl1

73% to fgenesh2_pm.scaffold_67000004|Brafl1

LTLTTFFVFCVAFLLACTLLKRARNLPPYPAGRVPLLGHLLALGRAPHLKLTAWRRQYGDVFTIKFGTEDVVVLNGYTAV

KDALVDRSELFASRPANYLFDSMVDSGNIAARWGPGFRQRKRFAITVLKNLGMKVGHGSIEDNIREEAICLRSRIADYNG

KPFDMTHDVTVAVANIICSMAFGKRYDYEDETFRELSKAVATTIFEIGAGQIINVFPLLRFVPVGNKNALKEFYKVQNVL

KDEISRHREHLNRENPRDFLDFCLLEVELQEKVEGLTEEQVLYMAQDLFFGGTDTTNNTLQWSLLYMTLNPDIQHKVHHE

LDTVVGASLPTLSHRPQLPYVNACLLETMRIRTLLPFTIPHATTQDVNVQGYDIPRGTQVLPNLYSLHMDPAYWPDPDRF

DPERFLDAEGNVISKPESYLPFGGGNHHIIVGN*

>fgenesh2_pm.scaffold_43000004|Brafl1

67% to fgenesh2_pm.scaffold_67000004|Brafl1

MNCLHPYLYFWHANVLLKRPKKLPPYPAGRVPVLGHLLALGRAPHLQLTVWRRQYGDVFTVRMGMEDVVVLNGYTAVKDA

LVDRSELFASRPQNYLLDTIVGCGKDIMSARWGTAVKQRRRFSITALKSLGMKIGTGSIEEKIKEEASYLRNKIVEYDGQ

AFDISNDVNVAVANIICSMVFGKRYDYGDKTFRELSESVSNVIAAMQGQIVTVFPLLRFVPGVNRSSMKALKLNSKIKAL

LWDEIAHHRENLDRENPRDFIDLLLLQLEQHEKVDNLTEENVMHITHNIFFAGMETTTNTLLWSLLYMTLNPGVQKKVQQ

ELDAVIGESLPALSHRPQLPYVNACLQEVMRIRTLLPLNVPHATTQEVKVQGFDIPKGIKVFPNLYSVHMDPAYWPDPDR

FDPERFLDAEGNVIDKPESFLPFSGGRRVCIGEKLARMELFLFFSTLLQSFTFKAPEGAPPTDGVVGITWGPHPFKLCAI

RR*

>fgenesh2_pg.scaffold_18000119|Brafl1 27% to CYP2G1P, 29% to CYP17A2 danio

86% to fgenesh2_pm.scaffold_43000004|Brafl1

MVYSLSGAPCWLQAGSRIGGQSAGSNIRLTNMAGLLKFGKLHHSQERYSASFRALMAVVETRKDMYQMSYEANIPDCTLC

EPGADLRVLGIGSGSGETDSAILKKLLQRHSSVYNRVVEPSGEMIGRYKTAEEYFQTKDDTKFHLIHAVHVLYYVEDLDA

TLRNLWEQLGDGGYMLVAIQSDKGGWGGLRHKLWEKFGQGDRVMTWCSTSGDVKQCLDTRGISYVTSVDEININVSECFK

DDSEAGKLLLDFLTHTPYVSSEPEIKSTALEYIRGLLKLGKLMHHSPGWYSVNFRAFLAALEMSKDMYQMYGPKVPDLTL

CELGADLRVLGIGSGSERYSESFRALIAAVETSRYQMSYGPKVPDSTLCEPGTDLRVLGIGSGSGKGDWGGLRHKLWEKF

GQGDRDRCSTSDDVKQCLDRRGISYVTSFDTTNINVSECFKENSENGKLLLDFLTHTPYVSSEPEIKSTALQYIRGRV PV

LGHLLALGRAPHLELTAWRRQYGDVFTIRLGMEDIVVLNGYTAVKDALVDRSELFASRPQSYLLDSTVGFEKADVDCLEV

PLDDLSIVHLRATSASLTPAEIVRNLRLFCIRSTHSQAQEELDAVVGESLPTLSHRSQLPYVNACLLEVMRIRTLIPVTI

HATTQDVEVQGYDIPKGS RNMGVCMREGGGYTCDCTRTGYYGQTRTAKYCNSHHIYISSVKSYEMHQADRCMSLSCTAEL

LTALGAALKPSDEMIDHLLFNYKWLWHIINNTQSLRNFLMRLLSKLSVGQVDSPPLYHTGHDYTSWDTYSARSYYTRALP

PVPADCPTPMGTKGPKELPSPEYLAETFLARRTFLPDTRRRTNVLFGFMAQHFTHQFFKTDFKKGPGHTWSDHAVDMSHV

YGETTERQHQLRSFQDGKLKYQLVDGEVFPPSLQDAPVHMIYPPNVPEDKRFALGHEFFGHLPGLFVWATVWLREHNRVC

DVMKKVHPDWDDERLFQTARLILIGETIKIVIEEYVQHLAGNNFQLVWDPELLFEERLQYQNRISVEFNHLYHWHMLMPD

HFDINGTMYTMEDYLFNNDIVLKHGLNATVDAMSRQIAGRVSATYLGHCIYNIIRAPGDAEMAAQLEEAYGDIDAVELYV

GWAMENPMPAGNVLSEMFVRMGSTFSFTGMLSNPICSPGWWKPSTFGGEVGFNLLKTTTLKDLFCRNMNGPCGLVSFSVP

EDVEPTGMPEAVEPAGLPEAEEPTGLPTDEGASQDKHTSQNQEL*

>estExt_fgenesh2_pm.C_1280009|Brafl1

72% to fgenesh2_pm.scaffold_67000004|Brafl1

MNTCVLILHLCCPGRVPILGHLLALGREPPLKLTAWRRQYGDVFTVRMGMEDVVVLNGYTAVKDALVDRSELFASKAPMY

QVDVMLGFGKDIFSASWGSEFRQRKRFATTVLKNLGMRVGRGSIEGNIREEANCLRNRIAENDGQPFDIAHDVTVAVANI

VCSKAFGKRYDYGDETFRELSQAINTVSSELATGQIISFFPWLRFVPVVNRSIVNVLKENSKVQKVLREEISRHREHLDR

ENPRDFIDFCLLEVDQQDKVDGLTEENVMYITKDLFFAGIETTTNTLLWSLLYMVSNPDVQNKVQQELDAVVGASLPALS

HRSQLPYVNACLMETMRIRTLLSVILHATAQEVKVQGYDISKGTRVLMNMHSLHMDPAYWPDPDRFDPERFLDAEGNVIN

KLPAFMPFSGGHRVCLGEQLARMELFLFFSTLLQSFTIKTPEGAPPPNTDGIFGLALKPHPFQLCAIPR*

>e_gw.97.101.1|Brafl1 43% to CYP2U1

96% to estExt_fgenesh2_pm.C_1280009|Brafl1

PFDIAHDVTVAVANIVCSKAFGKRYDYGDETFRELSQAINTVSSELATGQIISFFPWLRFVPVGRSIVNVLKENSKVQKV

LREEISRHREHLDRENPRDFIDFCLLEVDQQEKVDGLTEENVMYITKDLFFAGIETTTNTLLWSLLYMVLNPDVQNKVQQ

ELDAVIGASLPTLSHRSKLPYVNACLMETMRIRTLLSVILHATAQEVKVQGYDIPKGTRVLMNMHSLHMDPAYWPDPDRF

DPERFLDAEGNVINKLPSFMPFSGGHRVCLGEQLARMELFLFFSTLLQSFTIKTPEGAPPPNTDGIFGLALRPHPFQLCA

IPR*

>e_gw.399.27.1|Brafl1 43% to CYP2N2

68% to e_gw.97.101.1|Brafl1

KILKFIREEISRHRRDLDRENPRDFLDFCLIEVDRHDKVDNLTEENVMHVVQELLFGGIDTTTNTLRWGLMYMILYPDVQ

KKV

>e_gw.3.271.1|Brafl1

70% to fgenesh2_pm.scaffold_67000004|Brafl1

LNLQSFLVFCTAFVLACALLKRSRNLPPYPAGRVPVLGHLLALARAPHLQLTAWRRQYGDVFTVRMGMKDAVVLNGYTAV

KDALVDRSELFASRPPNYLFDLTVDFTGKDIAAARWGTQFKQRKKFATTAFKNLGMKMGNGSIQENIREEASYLRNRIAE

YEGEPFDIAHDVTVAVANIVCSMTFGKRYDYEDETFRELSEAIFTVIAEVGTGQIVSVFPLLRFVPVASVSVSRQIAKIQ

NVLKEEMARHREHLDRENPRDFIDFCLLELELQEKVEGLTDENVLYMAQDFFLAGTDTTTNTLLWSLLYMTLKPEVQNKV

HEELDAVVGASLPTLAHRSQLPYVNAFLMEVMRIRYVGPLGVPHATTAAVKVQEYDIPEGTQIILNLHSVHMDPAFWPDP

DRFDPDRFLDAEGNFINKPESFIPFSAGRRVCLGEQLARMELFLFFSTMLQSFTFKTPEGAPPPSTEGVLGLTLAPHPFQ

LCAIPR*

>fgenesh2_pg.scaffold_128000112|Brafl1 39% to CYP2D6, 34% to CYP2U1

95% to fgenesh2_pg.scaffold_97000132 (allele?)

70% to fgenesh2_pm.scaffold_67000004|Brafl1

MAAVARWIAESVQEILQISGLTLQAFLVLCAIFLLTCVIFKRSRNLPPYPAGRVPVLGHLLALGRAPHLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPNCLFDAVTGFGKDLASVPWGAAIRQRRKFTTTALKVLGMKVGSG

GIGEKIREEAGFLRSRVAEYEGKPFDVAYDLNVAVANVICSMVIGRRYDYKDETFRELSEAVVTVAVKLAAGQIISFFPW

LRFVPGVNRARVELLEQNARLQKVLGEELSRHREHLDRENPRDFLDFGLLELEKQEKVEGLTGEIVMHMAQNLFLAGTET

ASNTLRWSLLYMVLHPTVQKKVQEELDAVVGAILPTLSHRSQLPYVNACLMETMRIRTLLPVSLPHATTQDVKVSGYDIP

KGTQVLVNLYSIHKDPAYWPDPDRFDPERFLDAEGNVITKPESFLPFSAGRRVCPGEQLAGMELFLFFSTLLQSFTLSAP

EGAPPANTDGVFGLTLTSPPFKLCATPR*

>fgenesh2_pg.scaffold_97000132|Brafl1 34% to CYP2U1

70% to fgenesh2_pm.scaffold_67000004|Brafl1

MAAVIRWVAETVLEILQIPGLTLQTFLVLCAIFLLTCVVFKRSRNLPPYPAGRVPVLGHLLALGQAPHLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPNCLFDAVTGFGKDLASVPWGAAIRQRRKFTTTALKVLGMKVGSG

GIGEKIREEAGFLRSRVAEYEGKPFDVAYDLNVAVANVICSMVIGRRYDYKDETFRELSEAVVTVAVKLAAGQIISFFPW

LRFVPGVNKARVDLLEQNAKLQKVLGEELSRHREHLDRENPRDFLDFGLLELEKQEKVEGLTGEIVMHMAQNLFLAGTET

ASNTLRWSLLYMVLYPTVQKKVHEELDTVVGESLPTLSQRSQLPYVNACLLETMRIRTLLPVALPHATTQDVKVSGYDIP

KGTQVLVNLYSIHKDPTYWPDPDRFDPERFLDAEGNVINKPESFMPFSAGRRVCPGEQLAGMELFLFFSTLLQSFTLSAP

EGAPPANTDGVFGLTLTSPPFKLCATPR*

>e_gw.587.13.1|Brafl1

71% to fgenesh2_pm.scaffold_67000004|Brafl1

NLQSFLVFCTAFVLACALLKRSRNLPPYPAGRVPVLGHLLALGRAPHLQLTAWRRQYGDVFTVRMGMKDAVVLNGYTAVK

DALVDRSELFASRPPNYLFDLTVDFTGKDIAAARWGTQFKQRKKFATTALKNLGMKVGNGSIQENIREEASYLRNRIAEY

EGEPFDIAHDVTVAVANIICSMTFGKRYDYEDETFRELSEAIFTVIAEVGTGQIVSVFPLLRFVPVVNRASVSVSRQIAK

IQNVLKEEMARHREHLDRENPRDFIDFCLLELEVQEKVEGLTDENVLYMAQDFFLAGTDTTTNTLLWSLLYMTLKPEVQN

KVHEELDAVVGASLPTLSHRSQLPYVNACLMEVMRIRYVGPLGVPHATTAAVKVQEYDIPEGTQVILNLHSVHMDPAFWP

DPDRFDPDRFLDAEGNFINKPESFMPFSAGRRVCLGEQLAKMELFLFFSTMLQSFTFKTPEGAPPPSTEGVFGLTLTPHP

FQLCAIPR*

>e_gw.48.48.1|Brafl1 35% to CYP2U1

63% to e_gw.587.13.1|Brafl1

58% to fgenesh2_pm.scaffold_67000004|Brafl1

FKQRRRFVVRTLKNLGMKVGPGSIEENIRNEASCVQDRIADYEGKPFDIFHYVTVAVANVICSMTFGKRYDYEDEKFREV

SQASATVLAEIGAGQLISIFPFLRFVPGACLNVSEHLPKIHKFVKEEIDRHRGNLDRENPRDFLDFCLLELEQRGKVDGL

TKENVLYMAQDLFMAGTETSANTLRWSLLYLTLNPDIQKKAQEELDAVVGDSLPALPHRSRLPYVNACLMETMRIRTPGP

IPLHATTQEVNVREYTIPEGTRHVKNAPHLYQNYLPGMQNKQTNSYSKSDHTTGYLLFPGRRGCLGEQLGRMELFLFFST

LLQSFTFKTPEGASRPNTDGVFGMTLTPHPFQLRAIPR*

>estExt_fgenesh2_pg.C_180063|Brafl1 35% to CYP2J2 N-term

MAIIVSWIVESVLEILQISGLTLQTILVFCVAFLLACTFWKRPRNLPPYPAGRVPVLGHLLALGRAPHLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVRDALVDRSELFASRPPNYLFDLTVGFGEDIVTARWGSQFTQRRRFATTALRNLGMKVGTG

SIEEKIREEAIRLRNRVAEYEGKPIDIAHGINVAVANVICSMTFGKRYDYEDETFRELSEAVVTIMSELGAGQIISVFPL

LRFVPG GQYLNSRLRIL*

>estExt_fgenesh2_pg.C_3560052|Brafl1 96% to estExt_fgenesh2_pg.C_180063|Brafl1

38% CYP2J2

70% to fgenesh2_pm.scaffold_67000004|Brafl1

 MAVIVSWIVESVLEILQISGLTLQTILVFCVAFLIACTFLLKRPRNLPPYPAGRVPVLGHLLALGRAPHLTLTAWRRQYG

DVFTVRMGMEDVVVLNGYTAVKDALVDMSELFASRPPNYLFDLTVGFGEDIVTARWGSKFRQRRRFATTALRNLGMKVGT

GSIEEKIREEAIRLRNRVAEYEGKPIDIAHGINVAVANVICSMTFGKRYDYEDETFRELSEAVVTIMSELGAGQIISVFP

LLRFVPGVNRASYSVSGQLAKIQKVLREEMSRHREHLDHENPRDFLDFCLLELELQEKVAGLTEENVLYMTQNLFFGGTD

TTTNTLLWSLLYMILNPDIQKKAQEELDAVVGESLPTLSHRSQLHYVNACLLEVMRIRHIGPLAVPHATTDTVKVKEYDI

AKGTQVLPNLHSLHMDPAYWPDPDRFDPVRFLDAEGNVINKPESFMPFSGGRRVCLGEQLARMELFLFFSTLLQSFTFKT

PEGAPPPSTDGIFGITLTPHPFQLCAIPR*

>fgenesh2_pg.scaffold_128000104|Brafl1

73% to fgenesh2_pm.scaffold_67000004|Brafl1

MTGAVQWIADSVQEILQISELTLQTFLVLCSTFLLACVVFNRSRSRNLPPYPAGRVPVLGHLLALGRAPLLKLTAWRRQY

GDVFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRSPFYYLFDAIFGFGKDIISARWGSGFRQKKRFATTVLKNLGMRV

GRGSIEDSIREEASCLRNRIAENNGQPFDIAHDVAVAVANIICSMAFGKRYDYEDETFRELTKAIATISIELGAGHITSV

FPLLRFVPVVNRPIIKALEASSKVKNVMREEISRHREHLDRENPRDFLDLCLLELEQQEKVEGLTEENVFHMAQDLFLGG

TDTTANTLTWSLLYMTLNPDVQNKVHEELDAVVGESLPALSHRSQLPYVNACLLETMRIRTIVPLASHATTQEVKVQGYD

IPKGTQLMLTSPHMDPAYWPDPDRFDPERFLDAEGNVIKKPESFMPFSGGRRVCLGEQLARMELFLFFSTLLQSFTFKTP

VGAPPPNTDGIPGLTFMPHPFQLLAIER*

>fgenesh2_pg.scaffold_97000130|Brafl1

75% to fgenesh2_pm.scaffold_67000004|Brafl1

MAAVVSWIAGSVQEILLISGLTAQTCLVFCAAFLLAYVLLKRPQNLPPYPAGRVPVLGHLLALGRAPHLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPVYLFDAFGKNKDILTGHWDPGFKQRKRFSTTVLKNLGMKVGRGS

IEEKIVEEAKFLHNRVAEYEGKPFDIAHDVTVTVANVICTMTFGRRYDYEDESFQVLSEAVTAVGTELAAGQIISVFPSL

RFVPGVNRTGTNLVEHLSKLQRVLWEELSRHREHLDRENPRDFLDFGLLEVERQEKVDGLTEEIVIYLTQNIFVAGTETT

ADTLLWALLYLTQNPAIQHKVQQELDAVIGTSLPTLSDRSQLPYVNACLLETMRIRTLLQLPCGSALLFPYRPPHATTQD

VKVQQFDIPKGTQVLPNLHSLHTDPAYWPDPDRFDPERFLDAEGNVINKPESFMPFSGGRRVCLGEQLARMELFLFFSTL

LQSFTFKTPEGAPPPNTDGVVGITLTPHPFKLCAIPR*

>fgenesh2_pg.scaffold_128000111|Brafl1

77% to fgenesh2_pm.scaffold_67000004|Brafl1

MAAVVSWIAGSVQEILLISGLTAQTCLVFCAAFLLAYVLLKRPQNLPPYPAGRVPVLGHLLALGRAPHLKLTAWRRQYGD

VFTVRMGMEDVVVLNGYTAVKDALVDRSELFASRPPVYLFDAFGKNKGFKQRKRFSTTVLKNLGMKVGRGSIEEKIVEEA

KFLHNRVAEYEGKPFDIAHDVTVTVANVICTMTFGRRYDYEDESFQVLSEAVTAVGTELAAGQIISVFPSLRFVPGVNRV

GTNLVEHLSKLQRVLWEELSRHREHLDRENPRDFLDFGLLEVERQEKVDGLTEEIVIYLTQNIFVAGTETTADTLLWALL

YLTQNPAIQHKIHEELDAVVGASLPALSHRSQLPYVNACLLETMRIRTLVPLSAPHATTQDVKVQQFDIPKGTQVLPNLH

SLHTDPAYWPDPDRFDPERFLDAEGNVINKPESFMPFSGGRRVCLGEQLARMELFLFFSTLLQSFTFKTPEGAPPPNTDG

VVGITLTPHPFKLCAIPR*

 

$$$$$$

 

>e_gw.565.6.1|Brafl1 28% to CYP2J2

MKQLCNYC

RYGDIVAVRFGSEHVVVLNSYQAFKEAFVDLGPKFAGKASLPLAKLFSDNGKGIIFAPYSEAWREQRKFVLR

AMRLLRNGASNEETIIDQEAGTLVTSLLRYRGEPSNIQSDVALSIFNVTCAVVFGQRFKTDDVAYKEFVSSMNIISTNLG

SLGLSNAFPFLRKIPFLGFKDGNEDLESGFKQMRGFIANQVHQHRQTLDPNDIRGLLDVFLLEIQRRDGEDPGSFTDDQM

MQTVFDLFIAGVETVLSAFMWLVFYAARFPAVQAAVQAELDRVLMRGESVSAAHRRSLPVTEATVMEILRLATPSPLNFR

ATSCDVTLRGYHLPE

 

>e_gw.565.52.1|Brafl1 93% to fgenesh2_pg.scaffold_105000113|Brafl1

GTWTLMNCWAVHRDPLQWAEPDTFDFTRFLDREGKVTTPPTWRPFGIGRRACLGEQLARTELVVFFAALLHNFTL

>fgenesh2_pg.scaffold_105000113|Brafl1 33% to CYP2U1

95% to e_gw.565.6.1|Brafl1

MAFLLVYPREELLPFLLLLVLLLLWLCIRQSGRKSWPPGPPAWPVIGHLPWLGQRSHVNLTNWSKEYGDIVAVRFGSEHV

VVLNSYRAFKEAFVDLGPKFAGKASLPLAKLFSDNGKGIIFAPYSEAWREQRKFVLRAMRLLRNGASNEETIIDQEAGTL

VTSLLRHRGEPSNIQSDVALSIFNVTCSVVFGQRFKPDDVAYKEFVSSMNIISTSLGSLGLSNAFPFLRKIPFLGFKDGN

EDLESGFKQMRGFIANQVHQHRQMLDPNDIRGLLDVFLLEIQRREDDGEDPGSFTDDQMMQTVFDLFIAGVETVLSAFMW

LVFYAAKFPTVQTTVRAELDRVLMRGESVSAAHRRALPVTEATVMEILRLATPSPLNFRATACDVTLRGYRLPEGTWTLM

NCWAVHRDPLQWTEPDTFDFTRFLDREGRVTTPPAWRPFGIGRRTCLGEQLARTELVVFFAALLQNFTLSLHVPVGAPLP

SVEDAVLGVALMPAAFQTRTGVYTRTLPVSED*

 

$$$$$$$$$

 

>estExt_fgenesh2_pm.C_2310015|Brafl1 38% to CYP2U1

MAEWLDLTTVLVGVVVFFGSYVLFQSHREKRRQRLPPGPQGWPLIGHLPSMARDAHLQLTAWQHQYGDVYSIRIGLKKVV

VINGYETIREALVRKAAQFSSRPHLFLTDCTNGPDAVVMAPYGEKWRARRKIMLSALRNFGLGRDRFEQDIQDECRQLCH

AVAERQGRPFDIHRLLHNAVSNIICSISFNRRFEYDDPKFLLQMQMLDRILQLFQSCQIIDIFPVVRHLPILGNNYKEWQ

DLVGDGQHRFIKEIVSEHRTTFDPHNLRDAVDAFLYEMNNDENRGVFSGENVWNLLSDLFTAGSESVASTLQWALLWVMV

HDDVQKKVCEEIDRVVGRDRWPSLSDKPYMPYTEATLMETMRIRTPIPFAIPHENTVPATLQGYDIPANTYILVNLWSVH

MDPANWTDPEKFDPSRFLDDQGQLKSVKTYLPFSTGARVCPGEQLSRTELFLFFTSLLQRFTYRLPDDAPEPNLKGEIGI

TLAPPSYTLHATER*

>fgenesh2_pg.scaffold_231000065|Brafl1 40% to CYp2J2

100% to estExt_fgenesh2_pm.C_2310015|Brafl1

MVHNIKHHSLTGSLARLDPSLLLKLVQATNGSYRAAHLARLMMACPGAGWWCVPRIPVVGGGERQTCMNNT

IGLKKVVVI

NGYETIREALVRKAAQFSSRPHLFLTDCTNGPDAVVMAPYGEKWRARRKIMLSALRNFGLGRDRFEQDIQDECRQLCHAV

AERQGRPFDIHRLLHNAVSNIICSISFN

SCCRRRHRALSGGSMFCSCCRGCRSGRSIGTREGVTSVDAGSPWWAGARGTR

QLYTSRRRKYDYSLIRINVNDVCCAN*

>estExt_fgenesh2_pg.C_2310062|Brafl1

97% to estExt_fgenesh2_pm.C_2310015|Brafl1

MAEWLDLTTVLVGVVVFFGSYVLFQSHREKRQQRLPPGPPGWPLIGHLPSMARDAHLQLTAWQHQYGDVYSIRIGLKKVV

VINGYETIREALVRKAAQFSSRPHLFLTDCTNGPDAVVMAPYGEKWRARRKIMLSALRNFGLGRDRFEQDIQDECRQLCH

AVAERQGRPFDIHRLLHNAVSNIICSISFNRRFEYDDPKFLRQMQMLDRILQLFQSCQIIDIFPAVRHLPILGNNYKEWQ

DLVGDGQHRFIKEIVSEHRTTFDPHNLRDAVDAFLYEMNNDENRGVFSGENVWNLLSDLFTAGSESVASTLQWALLWVMV

HDDVQKKVCEEIDRVVGRDRWPSLSDKPYMPYTEATLMETMRIRTPIPFAIPHENTVPATLQGYDIPANTYILVNLWSVH

MDPANWTDPEKFDPSRFLDDQGQLKSVKMYLPFSTGAEIESGSRQVN*

 

$$$$$$

 

>fgenesh2_pg.scaffold_165000049|Brafl1 36% to CYP2U1

MSIISVLLSALNWSWSLQTLLVGVVVIITTVLWKRSAAAGLPPGPRGLPLVGNLFSMSKDTPVVYQEWSKKYGDVFTVYA

FRRPRVVLNGFSAIREALVTNADVFSSRPPFPVYGSPDQSARGLLLEPYTARFKEHKKFTMSALRDFGVGKRSMEGKILE

EARSLSDVITKKEKQAFCISRLLKNTTCNVICSLVFGSRYY

(Gap)

LKKGSERFLNNQLKLREHIREEIAKHKETFDPNDIRDFL

DTFLLEAKKREGDQNSTFTEEQHVELVRQLFLAGTDTTANTLYWAVLFMILHPDIQQKVQQEIASVLGPNQDPSMEHRSQ

MPYTEATLSEVSRVAATAPMAFGHFTTSDIVFRGYHIPKATSVEVNIWSVLRDPQLWPEPNKFDPTRFLDDTGKFTKREE

MIVFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKPPEGNDMPSAEGVFGLVYAPAPFQLVAELKK*

>fgenesh2_pg.scaffold_165000047|Brafl1 37% to CYP2U1

94% to fgenesh2_pg.scaffold_165000049|Brafl1

MSVLLPALSWSWSLQTLLVGVVVIITTVLWKRSATSGLPPGPRGLPLVGNLFSMSKGNPVVYLEWSKKYGDVFTVYAFRR

PRVVLNGFSAIREALVTNADVFSSRPPFPVYGSPDQSARGLLLEPYTARFKEHKKFTMSALRDFGVGKRSMEGKILEEAR

ALSDVITKKGNQAFCISRLLKNTTCNVICSLVFGSRY EYDDDKGKELLLMIEQTFSVKRHHMLPILFPVARVIPS

LKKGS

ERFLNNQLKLREHIREEIAKHKETFDPNDIRDFLDTFLLEAKKREGDQNSTFTEEQHVELVRQLFLAGTDTTATTLHWAV

LFMILHPDIQQKVQQEIDSVLGPNQDPSMEHRSQMPYTEATLSEVSRVAATAPMAFGHFTTSDIVFRGYHIPKATSVEVN

IWSVLRDPQLWPEPNKFDPTRFLDDTGKFTKREEMIVFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKPPEGNDMPSAE

GVFGLVYAPAPFQLVAELRK*

>fgenesh2_pm.scaffold_165000010|Brafl1

88% to fgenesh2_pg.scaffold_165000047|Brafl1

MSIMSVLLSAVNWPWSLQTLLVGVVVIITTVLWKRSSTAGLPPGPRGLPLVGNLFTMIRSKDSPVVYQEWSKKYGDVFTV

YAFRRPRVVLNGFSAIREALVTNADVFSSRPPFPVPGSPDQSAKGLLLEPYTPRFKEHKKFTMSALRDFGVGKRSMEGKI

LAEARSLSDVITKKEKQAFCISRLLKNTTCNVICSIVFGSRYEYDDVKGKELLQMIEQTFSTKALDLLPIAFPVARVIPS

LKKTSERYVNNQRKLMQHIREEITHHKETFDQNDIRDFVDAFLLEAKKREGDEHSTFTEEQHVTLVRQLFLAGTDTTATT

LHWAVLFMILHPDIQQKVQQEIDSVLGPNQDPSMEHRSQMPYTEATLSEISRMAATAPMTASHFTTSDIVFRGYHIPKAT

RVEVNIWSVLRDPQLWPEPNKFDPTRFLDDTGDFVRREELIMFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKPPEGSA

MPSAEGVFGLVHSPVPFQLVAEPRKK*

>e_gw.717.20.1|Brafl1

86% to fgenesh2_pg.scaffold_165000047|Brafl1

MSVLLSAVNWPWSLQTLLIGVVVIITTVLWKRAATAGLPPGPRGLPLVGNFPVVYQEWSKKYGDVFTVYAFRHPRVVLNG

FSAIREALVTNADVFSSRPHFPVPGSPDQSAKGKRLLLEPYTARFKEHKKFTMSALRDFGVGKRSMEGKILEEARALSDV

ITKKENQSFCISRLLKNTTCNVISSIVFGSRYEYDDVKGKELLQMIEQTFSTKTLGLLPIAFPVARVIPSLKKTSERYVN

NQRKLMQHIREEITHHKETFDPNDIRDFVDAFLLEAKKREGDEHSTFTEEQHVTLVRQVFLAGTDTTATTLHWAVLFMIL

HPDIQQKVQQEIDSVLGPNQDPSMEHRSKMPYTEATLSEISRMAATAPMTALHFTTSDIVFRGYHIPKSTRVEVNIWSVL

RDPQLWPEPNKFDPARFLDDSGNFVRREDLIMFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKPPEGSAVPSAEGVFGF

VHSPVPFQLVAEPRKK*

>fgenesh2_pg.scaffold_126000030|Brafl1

84% to fgenesh2_pg.scaffold_165000047|Brafl1

MSVLLSSLNWPWSLQTLLVGVVVIITTVLWKRSATTGLPPGPRGLPLVGNLFSMTKDIPVVFQKWSKKYGDVFTVYAFRQ

PRVVLNGFSAIREALVTNADVFSSRPVQKVKVQKQVNQKTDHLNPNSSAKCTFLPYTARFKEHKKFTMSALRDFGVGKRS

MEGKILEEAQALSDFILKKEKQAFCISRLLKNTTCNVISSIVFGSRYEYDDVKGQELLLMIEQTFSINRIHMLPIMFPKA

RVIPSLREGSERFLNNQIKLREHFREEVAKHKETFDRNDIRDFIDAFLLEADKREGDEDSTFTEEQLVEILRQLFLAGTD

TTANTLHWAVLFMILHPDIQQKVQQEIDSVLGPNQDPSMEHRSQMPYTEATLSEINRMAATVPMASRHFTTGDIDFRGYH

IPKATAVEVNIWSVLRDPQLWPEPNKFDPTRFLDDTGMFTKREEMIVFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKP

PEGSAVRSAEGVFGLVYAPAPFQLVAEPRK*

>fgenesh2_pg.scaffold_15000018|Brafl1

85% to fgenesh2_pg.scaffold_165000047|Brafl1

MSIMSVLFSALNWPWSLQTLLAGVVVIITTVLWKRSATTGLPPGPRGLPLVGNLFSMTKNIPVVFQKWSKKYGDVFTVYA

FRQPRVVLNGFSAIREALVTNADVFSSRPYVPILGSPDQSAKGLLFEPYTARFKEHKKFTMSALRDFGVGKRSMEGKILE

EAQALSDFILKKEKQAFCISRLLKNTTCNVISSLVFGSRYEYDDVKGQELLLMIEQTFSINRIHMLPILFPKAKEVA

KHK

ETFDRNDIRDFIDAFLLEADKREGDENSTFTEEQLVEILRQLFLAGTDTTANTLHWAVLFMILHPDIQEKVQQEIDSVLG

PNQDPSMEHRSQMPYTEATLSEISRMAATVPMASRHFTTGDVDFRGYHIPKATAVEVNIWSVLRDPQLWPEPKKFDPTRF

LDDTGMFTKREEMIVFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKPPEGSAVRSAEGVFGLVYAPAPFQLVAEPRK*

>fgenesh2_pg.scaffold_306000046|Brafl1

82% to fgenesh2_pg.scaffold_165000047|Brafl1

MSVLLALTWPWSLQALLVGVVVIITTVLCKRSSIPGLPPGPRGLPLVGNLFSMTKDMPLVFQEWSKKYGDVFTVYMFRQP

RVVLNGFRAIRETLVTNADVFSSRPPTSILGPDQNAKGLILEPYTPRFKEQKKFTMSALRDFGVGKRSMEGKILEEVRAL

IDVITKTENQAFSISRLLKNTTSNVICSLVFGSRYEYDDVKGNELLLMIEQTFSTKAFDLLPIAFPAARMIPSLKKATER

YQNNQRKILQHIREEIAKHKETFDRNDIRDFLDAFLLEATKREGDQNSTFTEEQLVSLVRQLFLAGSDTTANTLHWAVLF

MILHPDIQQKVHQEIDSVVGPNQDPSMEHRSKMPYTEATLSEISRMAATVPMAPRHFTTSDIFLRGYHIPKATRVEVNIW

SVLRDPQLWPEPYKFDPTRFLDGSGKFVRREELILFSMGRRLCPGERLAKVELFLIFTSLLQRFTFKPPEGSRMPSADGV

FSVVHSPAPFQMVAEPRKKK*

 

$$$$$$$$

 

>fgenesh2_pm.scaffold_117000003|Brafl1 42% to CYP2U1

MVIWSVFDLLTPWGLSWTLLLVLSCLTAVQYLQRPANLPPGPRGWPVIGNLYSLRKCRIKGQLAFAKYQVSKCFKRKSIL

TEWAKEYGDIVSYHTGSKLRIVLNSYSVVHEAFVKKFDIFSGRPEPLTSFMAQRKAKGIVCGSYGPTLKEHRRFSMKSLR

DFGVGKSSLEGKIIEEARALADKISKHEHQEFRIHRMTRAAVSNVIASIVFGFRYEYDDPEFQALLYSVSESFSISLLSL

LPAIFPTLQYIPGANNGLKRYEKILMKVFKHVQEEIKEHKKDFNPDDVRDFIDAFLLEIKNRENEEDRAFIEEQLVTIVV

DLFFAGFDTTSNTLQWALLYMILHPDIQEKVQQEIDSVIGRNQDPSMVHRNQTPYTAATLAEVERLATVAPLALAHTTTE

ETTFRGYNIPKGTIVEPNIWAIHHEPQLWPHPHKFDPTRFLDNTGKFVKRDKLIPFSIGRRACLGEQLARMELYLFFTYL

LQRFSFKLPEGAPVPSAKGEFGLTHAPITYELVAVPRHLPSETCPTY*

 

>fgenesh2_pg.scaffold_117000051|Brafl1 94% to fgenesh2_pm.scaffold_117000003|Brafl1

MGPVLDAPSRPELPDSGAVSTAPRQPASRSQGLACNREPLQLEKDVSVPHSVLQVFDPKPHITGKLVYETPLVLTEWAKE

YGDIVSYHTGSQLRIVLNSYDVVPEAFVKKFGIFSGRPKPLTSLMAQRKEKGIVCESYGPTLKEHRKFSMKSLRDFGVGK

SSLEGKIVEEARALADKISKHEHQEFRIHRMTRAAVSNVIASIVFGSRYEYDDPEFQALLYSVSESFSISLLSLLPAIFP

TLQYIPGANNGLKRYEKILMKVFKHVHEEINEHKKDFNPHEIRDFIDAFLLEIKNRENEEDTAFTEEQLVTIVVDLFFAG

FDTTSNTLQWALLYMILHPDIQEKVQQEIDSVIGRNQDPSMVHRNQTPYTAATLAEVERLVTVAPLALAHTCTEETTFRG

YNIPKGTVVEPNIWAIHHDPQLWPHPHKFDPTRFLDDTGKFVKREELIPFSIGRRACLGEQLARMELYLFFTYLLQRFSF

KLPEGAPVPSAKGEFGLTHAPITYELVAMPRHLPSETCPTY*

 

>fgenesh2_pg.scaffold_117000059|Brafl1 98% to fgenesh2_pm.scaffold_117000003|Brafl1

MVIWSVFDLLTPWGLSWTLLLVLSCLTAVQYLQRPANLPPGPRCWPVIGNLYSLRK

(gap) 84% to fgenesh2_pm.scaffold_117000003|Brafl1

VVVDLFFAGTDTTSTTLQWALLYM

ILHPDIQEKVQQEIDSVIGRNQDPSMMHRAQTPYTAAVLAEVERLATIAPLSLAHTTTEDTFLRGYYIPKGTVVEPNIWA

IHHDPQIWTNPNKFDPTRFLDDTGKFVKRDELIPFSIGRRACLGEQLARMELYLFFSSLLQRFSFKLPEGTSIPSVKGEF

GLTHAPKSYNLVTVPRNQSFVYLCSDTNE*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_271000044|Brafl1 38% to CYP2D6, 37% to CYP2U1, 39% to CYP2Z2

MNKKSRRTGTFPPGPPAWPLLGHLPLLGRRPHVKFSEWSREYGPVLGVKFGPQQVVVLNGYAAVREALVTKAEVFSSRPD

LYLMRLFSNGKGIGLAPYCAKWKAQRKVTDRALRNLGVGKLSFEPKIMEEVEDFVSAAEGYDGAAFNPKYHIAVGVLNII

CHLVFGRRFQHDDPLFVKLYNALEDISRHGGSAQHLNIFPALRHVPGLNAGAMHTMRAVREGRDFVREMIGQHRATYDPE

NIRDYIDAYLHQLQKEREDGEKSVTYLSDEELEQNVFDLFIAGSESTATTLQWATLLLMVNPEVQEKVQQELDDVLGDRQ

TSVLDRASLPYTQATIQEILRFRPSATFGLPHATTADTTLQGYDVPAGTQVLVNVWGMGMDPALWRRPGTFDPTRFLDTE

GKLSVPEYFKPFLVGRRACIGSQLAKMQLLLYITTILQRFSLRVPEGATPPSLDGNLGVILQCPSFRMCAVPR*

>fgenesh2_pm.scaffold_4000005|Brafl1 99% to fgenesh2_pg.scaffold_271000044|Brafl1

MASPKLQTSPTRLFVGDTTYGLALVLVLLLVFMNKKSRRTGTFPPGPPAWPLLGHLPLLGRRPHVKFSEWSREYGPVLGV

KFGPQQVVVLNGYAAVREALVTKAEVFSSRPDLYLMRLFSNGKGIGLAPYCAKWKAQRKVTDRALRNLGVGKLSFEPKIM

EEVEDFVSAAEGYDGAAFNPKYHIAVGVLNIICHLVFGRRFQHDDPLFVKLYNALEDISRHGGSAQHLNIFPALRHVPGL

NAGALHTMRAVREGRDFVREMIGQHRATYDPENIRDYIDAYLHQLQKEREDGEKSATYLSDEELEQNVFDLFIAGSESTA

TTLQWATLLLMVNPEVQEKVQQELDDVLGDRQTSVLDRASLPYTQATIQEILRFRPSATFGLPHATTADTTLQGYDVPAG

TQVLVNVWGMGMDPALWRRPGTFDPTRFLDTEGKLSVPEYFKPFLVGRRACIGSQLAKMQLLLYITTILQRFSLRVPEGA

TPPSLDGNLGVILQCPSFRMCAVPR*

 

$$$$$

 

>fgenesh2_pm.scaffold_72000008|Brafl1 39% to CYP2J2

MSYLRFLWFYLLMLITVVLICFVAFLVSLTVAAKFSAHGRRNTPPGPPGWPVLGNLPSLTKDIHLQLTKWRYQYGDVFSV

RFGLQDAVIVNGSEAIKEALVQKANHFSNRPDYYLVRCVNMHFGAVFCLYGDRWSALRRFTVSTLRFFGMGTTILEEKIQ

EECRHFCSALRLLVGQPVDLKNRLETSVSNIIVYMAVGKRFEYGDPKFGRLQILAERINVTFYKLYIVNCFPMLRFFPGF

RKMYNELMDRTAELYSYIREYIGQHGNTAPDDIRDFIDAFNKTKQDNPGFLPDMTLTYLIADLFSAGTETSSLTLCWGFL

YLTAYPDVQEKVQAELDRVVGRDRPPAFSDRINLPYTEATIMEIQRIATIIPLLPHRTSDDTTLLGYDIPAGTNVIVNLW

DLHMDPSRWPDPHRFDPARFLGENGRLLTHDAFMPFSTGYRRCWGEQMGKMELFLFLTNTLQQFTLKLPEGTEPDFHGIS

TAFIYPRPFSLIVTKRE*

>gw.85.76.1|Brafl1 35% to CYP2U1

95% to fgenesh2_pm.scaffold_72000008|Brafl1

ITVVLVCFVAFLVSLAVVAKFSVHGRRNIPPGPPGWPVLGNLPSLTKDIHLQLTKWRYQ

(gap)

YGDVFRVRFGLQDAVIVNGSE

AIKEALVQKAKHFSNRPDYYLVRCVNMHFGAVFCPYGDRWRALRRFTVSTLRFFGMGTTILEEKIQEECRHFCSTLRLLV

GQPVDLKNRLETSVSNIIVSMAVGKRFEYGDPKFGRLQLLAERINVTFYRSYIVNCFPVLRFFPGFRKMYNELMDRTAEL

YSYIREYIGQHGNTAPDDIRDFIDAFNKTKRDNPGFLPDMTLTYLIADLFSAGTETSCLTLCWGFLYLTAYPDVQNKVQA

ELDRVVGRDRPPAFSDRINLPYTEATIMEIQRIATIIPLLPHRTSDDTTLLGYDIPAGTNVFVNLWDLHMDPSRWPDPHR

FDPARFLGENGRLLTHDAFMPFSTGYRRCWGEQMGKMELFLFLTNTLQQFTLKLPEGTEPDFHGISTAFIYPRPFSLIVT

KR

>e_gw.85.5.1|Brafl1

95% to fgenesh2_pm.scaffold_72000008|Brafl1

LFACFFRSQVDFTKHCHRWLL

NTPPGPPGWPVLGNLPSLTKDIHLQLTKWRYQYGDVFSVRFGLQDAVIVNGSEAIKEAL

VQKAKHFSNRPDYYLVRCVNMHFGAVFCPYGDRWRALRRFTVSTLRFFGLGTTILEEKIQEECRHFCSTLRLLVGQPVDL

KNRLETSVSNIIVSMAVGKRFEYGDPKFGRLQLLAERINVTFYKLYIVNCFPVLRFFPGFRKMYNELMDRTAELYSYIRE

YISQHGNTAPDDIRDFIDAFNKTKQDNPGFLPDMTLTYLIADLFSAGTETSSLTLCWGFLYLTAYPDVQEKVQAELDRVV

GRDRPPAFSDRVNLPYTEATIMEIQRIATIIPLLPHRTSDDTTLLGYDIPAGTNVFVNLWDLHMDPSRWPDPHRFDPARF

LGENGRLRTHDAFMPFSTGYRRCWGEQMGKMELFLFLANTLQQFTLKLPEGAEPDFHGISTAFIYPRPFSLIVTKRE*

>CYP2C founder fgenesh2_pm.scaffold_164000001|Brafl1 38% to CYP2C19

possible CYP2C founder

92% to fgenesh2_pm.scaffold_72000008|Brafl1

note in humans CYP26C1 and CYP26A1 are adjacent and near CYP2C gene cluster

Brafl1/scaffold_164:301644-308026 (450kb from CYP26 genes)

Human 2C genes and 26 genes are 2.3 million bp apart.

MTVVLICFVASLVSLVVVAKFSAHGRRNTPPGPPGWPVLGNLPSLTKDIHLQLTKWRYQYGDVFSVRFGLQDAVIVNGSE

AIKEALVQKAKHFSNRPDYYLVRCVNMHFGAVFCPYGDRWRALRRFTVSTLRFFGMGTTILEDKIQEECRHFCSTLRLLV

GQPVELRDRLETSVSNIIVSMAVGKRFEYGDPKFGRLQALAERINVTFYKLYIVNCFPVLRFLPGFWKMYNELMNLTAEL

YNYIREHIGQHGNTAPDEIRDFIDAFNKTKQGFLPDMTLTYLIADLFSAGTETSSLTLCWGFLYLTAYPDVQEKIQAELD

RVVGRDRPPAFSDRVNLPYTEATIMEIQRIATIIPLLPHRTSDDTTLLGYDIPAGTNVFVNLWDLHMDPSRWPDPHRFDP

ARFLGENGRLLAHDAFMPFSTGYRRCWGEQMGKMELFLFLANTLQQFTLNPNSSTPKNPPHVQWCGVRFYG*

>gw.984.5.1|Brafl1 38% to CYP2U1

94% to fgenesh2_pm.scaffold_72000008|Brafl1

PPGPPGWPVLGNLPSLTKDMHLQLTKWRYQYGDVFSVRFGLQDAVIVNGSEAIKEALVQKAKHFSNRPDYYLVRCVNMHF

GAVFCPYGDRWRALRRFTVSTLRFFGMGTTILEDKIQEECRHFCSTLRLLVGQPVDLRYRLETSVSNIIVSMAVGKRFEY

GDPKFGRLQALAERINVTFYKLYIVNCFPMLRFFPGFRKMYNELMDLTAELYNYIREHIGQHGNTAPDEIRDFIDAFNKT

KQGFLPDMTLTYLIADLFSAGTETSSLTLCWGFLYLTAYPDVQEKVQAELDRVVGRDRPPTFSDRINLPYTEATIREIQR

IATIIPILPHRTSDDTTLLGYDIPAGTNVFVNLWDLHMDPSRWPDPHRFDPARFLGENGRVLTHDAFMPFSTGYRRCWGE

QMGKMELFLFLANTLQQFTLKLPEG

>fgenesh2_pg.scaffold_143000008|Brafl1 36% to CYP2P3

93% to fgenesh2_pm.scaffold_72000008|Brafl1

MHLQLTKWRYQYGDVFSVRFGLQEAVIVNGSEAIKEALVQKAKHFSNRPDYYLVRCVNMHFGAVFCPYGDRWRALRRFTV

STLRFFGMGTTILEDKIQEECRHFCSTLRLLLGQPVDIKNRLETSVSNIIVSMAVGKRFEYGDPKFGRLQALAERINVTF

YKLYIVNCFPMLRFIPGFRKMYNELMDLTAELYNYIREHIGQHGNTAPDEIRDFIDAFNKTKQGFLPDMTLTYLIADLFS

AGTETSCLTLCWGFLYLTAYPDVQEKVQAELDRVVGRDRPPAFSDRINLP

(gap)

RWPDPHRFDPARFLGENGRVLTHDAFMPFST

VGSDARNFQSTA*

 

$$$$$$$$

 

>e_gw.566.3.1|Brafl1 37% to CYP2J2

MSLIENIAGFVNLQTVLVLLVVLLMTYVYVTRPRNLPPGPWGWPIVGNLYTLSKGNIHLTLSKWRKKYGAIVFFKIGTLG

TVCLNDYDVIKEAYVRRSDMFGNRPTNLRIVNQLINQKGIIFAPLGPHWWEQRQFAVASLGFGSLRINERILEEAATMQA

ELLKTKG

KPFNIRRMLQQASTNVVCYMVFGKRWDYTNQTFQNIMQSLDVVFRTSVFFLPENVFPYVPGFLKRGDKVNVEK

VLQLVRDEVKEHKETFNRDNIRDFIDSFLLEMQNQTDLDGSTFTERQLEMTVFDLFNAGTETVSTTMWWACLLMILNPDV

QNKVQEEIGQVLGRDSRPSMAYRSQMPYTTATVAEIQRYGAVSPIGLPHAVPRDTEFYGYIIPKDTIVFAGQWSVHHDPE

LFPEPDMFDPERFLDDEGNFKNIEYFMPFSMGPRSCMGQPLAEVQLFLLFTNLMQNFKLKLPEGAAKPSSEGVMGITLAP

KPFDLVAIPRD*

>e_gw.274.15.1|Brafl1 10 aa diffs and an insertion vs. e_gw.566.3.1|Brafl1 (allele)

MSLIENIAGFVNLQTVLVLLVVLLMTYVYVTRPRNLPPGPWGWPIVGNLYTLSKGNIHLTLSKWRKKYGAIVFFKIGTLG

TVCLNDYDVIKEAYVRRSDMFGNRPTNLRIVNQVINQKGIIFAPLGPHWWEQRQFAVASLGFGSLRINERILEEAATMQA

ELLKTKG

INRHFFYIG

KPFNIRRMLQQASTNVVCYMVFGKRWDYTNQTFQNIMQSLDVVFRTSVFFLPENVFPYVPGFLK

RGDKVNVEKVLQLVRDEVKEHKETFNRDNIRDFIDSFLLEMQNQTDIDGSTFTERQLEMTVFDLFNAGTETVSTTMWWAC

LLMILNPDVQNKVQEEIEQVLGRDSRPSMAQRSQMPYTAATIAEIQRYGAVSPIGLPHAVPRDTEFYGYIIPKDTIVFAG

QWSVHHDPELFPEPDMFDPGRFLDDEGNFKNIEYFMPFSMGPRSCMGQPLAEVQLFLLFTNLMQHFKLKLPEGAARPSSE

GAMGITLAPKPFDLVAIPRD*

>fgenesh2_pg.scaffold_218000071|Brafl1 36% to CYP2J2

68% to e_gw.566.3.1|Brafl1

MSLIYDIPGLLDFSTLLLGIVVFLMTYAYVTRPKNLPPGPWSLPIVGNLPTLILAKGKIHHTFGEWRKKYGAIVFFKIGT

LNAVCLNDYDVIREAYVRRSDMFGNRPTNLRVVNELFDQKGILSASLSPQWQERRKFVRGGLGFGNRGIEDKVLEEALNM

QTELLKTKSKSFNIRRMLQQAVTNVLCSMLFGKRWDYESQTFQDLMESLDVVFHRSSIFFVQENVFPYVPWFLKRGDKKK

ARLERILEHVRAEIKEHKETFNRDDIRDFIDAFLLEMLNRPDTCTDPDDGAFTDRHLEITVLDLFLAGTETVSTALWWAC

LLLILNPDIQHKVQEEIEEVIGREGRPTMALRTQMPYTTATVTEIQRYRSASTIGIPHAVPRDTDFYGYTIPKDTLVFGG

QWQVHHDPELFPDPEKFNPGRFIDSDGKFKKDEHMMPFSMGPRTCVGKPLADVEVFLLLTFLFQRFNFELPEGARTPSDE

GIMGISQAPAPYELVAIPRD*

>fgenesh2_pg.scaffold_89000006|Brafl1 48% to 2U1 fugu

MHFGRIAE

88% to fgenesh2_pg.scaffold_218000071|Brafl1

YTIPKDTLVFGGQWPVHHDPGLFPDPDRFDPGRFIGSDGKYKKDEHMMPFSMGPRTCVGKPLAEVEVFLLFT

FLFQRFNFELPDGARTPSAEGIMGITLAPAPYELVAIPRD*

 

$$$$$$$$

 

>estExt_gwp.C_9060005|Brafl1 40% to CYP2AA7

MSLLLHVVSGVRTFLDLQTILVLLVSFLGVLWFVRRGRNYPPGHWKWPILGNIPHIYKDPHLVYTRWAQRYGPVLHVQLG

QKDAVVLNGYETVHKAFVGKAEDFSGRPTFIYFVDKISEGGKGVIFAPYGSFWKEQRKFTLMSLRDFGFGKRSIEGKIVE

ESQALQSEIAKFDGQPFSTHRLLQNAVANVICNIVFGDRWEYDDPLFQRMMDALDYMVSTNVFAVPQNFIPFTRYLMSIL

YKLHISHFLSIMGYLREELDKHKASFDPNDLRDFIDAYLLEIQKQKGVEGTRFKEDQLLQIMRDMFFAGAETTATTIRWT

LFYMVIYPDVQRKVYEEIDQLLGKTPPSVSHRSQLPYTDAVLAEVQRIATVVPLGIPRATSNDTTLNGYNIPKDWILFVN

LWSVHHDPQRWPDPERFDPGRFLDENGKFQKPEGFIPFSTGHRVCLGEQLARVEIFIFVITLLQHFELKLPEGAPVPSRK

GTMGVTHAPQPHNIVAIPRD*

>e_gw.67.139.1|Brafl1 39% to CYP2J2

95% to estExt_gwp.C_9060005

MSLLLHVVSGVRTFLDLQTILVMLVSFLGVLWLVRRGRNYPPGHWKWPILGNIPHIYKDPHLVYTRWAQRYGPVLHVQLG

QKDAVVLNGYETVHKAFVGKAEDFSGRPTFIYFVDKISEGGKGVIFAPYGHFWKEQRKFTLMSLRDFGFGKRSIEGKIVE

ESQALQSEIAKFDGQPFSTHRLLQNAVANVICNIVFGDRWEYDDPLFQRMMDALDYMVSTNVFARFVNPLVFLRRYIPGW

EGRLEPWMKKFLSIMGYLREELDKHKASFDPNDLRDFIDAYLLEIQKQKGVEGTRFKEDQLLQIMRDMFFAGAETTATTI

RWTLFYMVIYPDVQRKVYEEIDQLLGKTPPSVSHRSQLPYTDAVLAEVQRIATVVPLGIPRATSNDTTLNGYNIPKDWIL

FVNLWSVHHDPQRWPDPERFDPGRFLDENGKFQKPEGFIPFSTGHRVCLGEQLARVEIFIFVITLLQHFELKLPEGAPVP

SRKGTMGVTHAPQPHNIVAIPRD*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_188000102|Brafl1 43% to CYP2C18

MTIWTGSAPNIVLTGYETIRAALVKRAEDFSSRKAPPAMLDVRGDGTANGTKGVIFATYGPRWKQRRKFALMTLRDFGFG

KRSLEGKVTEEANALVQEVLSQNGQPFDLKIMMQNAVSNVICSIVFGDRFEYGDPDFLRLIRLLNAFVEAKPTVRDLLTM

IHPLFRHLRHIE

(gap) 47% to CYP2U1

ASREGKSVHQEIDSVLGQSAPSYAQQNLLPYTAATLAEAMRMKPIVPIVVRAPSRDTTLKGYNIPQEA

GIMVNLWSVHMDPQLFPEPNTFQPERFLDQDGNFVKHEAVMPFSTGHRVCLGEQLAKMELFMFFVSLMQRFTFHLPEGAP

KPSMVGSIRPGVAINVPFPFELCAVPRG*

>fgenesh2_pg.scaffold_2000356|Brafl1 51% to CYP2U1

97% to fgenesh2_pg.scaffold_188000102|Brafl1

MDLSFLSYHSQVNLWSVHMDPQLFPKPNTFQPERFLDQDGNFVKHEAIMPFSIGHRVCLGEQLAKMELFMFFVSLMQRFT

FHLPEGAPKPSMVGSIRPGVAINVPFPFELCAVPRG*

 

$$$$$$$$$$$

 

>fgenesh2_pg.scaffold_241000019|Brafl1

MAAAGSYLAIFEFSRLNCQTYLVFCIAFLLACLYLRRSRNLPPYPAGRVPVLGHLLALGRAPHLQ

LTAWRRQYGDVFTVR

IGMQDVVVLNGYTAVKDAMVDRSELFASRPPNYIPDLLTGFGKDIVGTRWGQEFKQKKRFATTVLKTLGMKVGKGSIEEK

IQEEGRSLCERFAAYQGRPFDAERDLQVTIANVICAMAFGHRFAYGDERFAEMAEAIVSVQMNLASLSGQLISVFPFLRFVPG

(gap) 50% to CYP2U1

EATVMEVQRVRTTVPMGLPHATTQHVKLGQFDLPAGTQVLTNLYSLHTDPAYWPDPDRFDPDRFLDGEGHVIGKPHS

FMPFSGGRRVCLGEQLAKMELILLFCGLMQNFTFKLPEGAPPVSTGGILRISLTPHPHNICAIPR*

>fgenesh2_pg.scaffold_140000022|Brafl1 39% to CYP1A1

93% to fgenesh2_pg.scaffold_241000019|Brafl1

MAAVVPNLAIFELSRLNFQTYLVFCLAFLLACLYLRRSRNLPPYPAGRVPVLGHLLALGRAPHLQLTAWRRQYGDVFTVR

IGMQDVVVLNGYAAVKDAMVDRSELFASRPPNYIPDLLTGFGK

>fgenesh2_pg.scaffold_191000030|Brafl1 27% to CYP27C1

MGITGVLGRRCDAVMRSGRVLNGQCKCGRSSLWNVGLCILRKSSSTVTNVGMETCVDPTANKTDVAVRPFHEIPGPKGLP

IIGSLWEYTFLGKLDPRRFDEVLWNRYQEYGKIYKEDLGPRGTFVRIADPGDIETVYRNEGRYPHRPSFPLVRESMEAAG

QELLKHRARSESSFNGQGLEWYRTRSAVNRTLLRRSGVALFHPTLNEISDDFLALLKRSLDENNTVPDITWQIRRYNTEV

AGTTIFGRRPGCLEPDFSGSCQTSEMIKSIDDFFASWLKLEIGFPLTKYLLKDTWNGYMNAHRNILRIVKYHMDLDVEYE

DSRPSVLGYLLSESSLSDTDAAMSAVELFVGGMQSSSHADMFQLYELARHPHVQETIRREVTEALPKGEAVTSAHLHKLP

YLKAFVKETFRFHPVGLLHMRILDRDVVLSGYRVPAHTTIEIPMSVLGRLEELYPQADRFLPERWLRRGPNGFRSRMFSH

VTPFGHGPRACIGRRLAEDKFYIQIAKLVQNFDLHCDEEADTVTGCFQELSPTPNIRFTPR*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_248000011|Brafl1 38% to CYP17A1

MSLLQLYPALCVSDVVWVVALFALLYGLVYAGERRDLVLPPGPTPLPIIGNLLNMVGADPHIRMTQMAKKFGDVYQVWIG

MEKVIVINDIDLAKEALVKNGDDFAGRAHLPTTDLLSNSGMGIAFADYGRGWRIHKKLTHNSLKMFGNGMQQLESRISEE

ADWLCSHIAASAGRPLDPYLGLNVVIGNIISSLCLGKRYHPEDPEFRTIVRYNEGLVDTVGKDGLIDVFPLLAKLPNATV

RKMKECLELRNKVLSKNIEEHRATYQDGKIRDLIDTLLKAQAEAVMASGHRALRHLSDQHILITVNDVFGGGMETATTTL

RWILLFLVHYPEVQ DRIQAEMQQVLCANDPVRLSDRERLPYLEATIREVLRMRPVAPLAIPHVTIRDTS VGDFDVPQGTR

VMFNLWAIHHDERHWTDPATFNPDRFLDAKTGQLLRGGSFLPFLAGCRGCLGESMAKAELFLFTARILRDFRLELPDGVS

PPSLQGRYGVVMAPDRYDICFRPREEQL*

>fgenesh2_pg.scaffold_157000072|Brafl1 missing N-term

90% to fgenesh2_pg.scaffold_248000011|Brafl1

MEKVIVINDIDLAKEALVKNGDDFAGRAHLPTTDLLSNSGMGIAFADYGRGWRIHKKLTHNSLKMFGNGMQQLESRISEE

ADWLCTHLAASAGRPLDPYLGLNVVIGNIISSLCLGKRYHPQDPEFRTIVRYNEGLVDTVGKDGLIDVLPLLAKLPNSTV

RKMKQCLKTRDNVLNNNIDEHRGSFKDGHPRDLVDALLKAQAEAAAEGGRKAQRYLSDEHILTTVNDVFGGGMETSTTTL

RWILAFLLHHPEVQ KRIQAEMQQVLCANDPVRLSDRERLPYLEATIREVLRMRPVAPLAIPHVAIRDSS

97% to fgenesh2_pg.scaffold_248000011|Brafl1

97% to fgenesh2_pm.scaffold_248000001|Brafl1

VGDFDVPQGTR

VMFNLWAIHHDERHWTDPATFNPDRFLDAKTGQLLRGGSFLPFLAGCRGCLGESMAKAELFLFTARILRDFRLELPDGVS

PPSLQGRYGVVMAPDRFNICFRPRKA*

>fgenesh2_pm.scaffold_248000001|Brafl1

82% to fgenesh2_pg.scaffold_157000072|Brafl1

70% to fgenesh2_pg.scaffold_248000011|Brafl1 probable hybrid seq

MFAEKKRTQFAPPGPRPLPLIGNLLDMVGADPHIRLTEMAETFGTVFQVRFGREPVVVINDIDLAKEALVKNGDDFAGRA

HLPTTDLLSNSGMGIAFADYGRGWRIHKKLTHNSLKMFGQGMFQLEDKITTEADWLCGYLKTSSGAPLDPYLPLNTVVGN

VISSICFGKRFEPEDDEFRTIIGYNEGLVDTVGKDALIDVFPWLAKLPNSTVTKMKQCLKTRDNVLNNNIEEHRVNIFFK

LIIIFFTIEGSFKDGQPRDLVDALLKAQAEAAAEGGRKAQRYLSDEHILTTVNDVFGGGMETSTTTLRWILAFLLHHPEKQ

(gap)

100% to fgenesh2_pg.scaffold_248000011|Brafl1

VGDFDVPQGTRVMFNLWAIHHDERHWTDPATFNPDRFLDAKTGQLLRGGSFLPFLAGCRGCLGESMAKAELFLFTARIL

RDFRLELPDGVSPPSLQGRYGVVMAPDRYDICFRPRNA*