CYP4 clan (54 sequences in 11 bins)

 

$$$$$$$$$$

 

>fgenesh2_pg.scaffold_195000012|Brafl1 45% to CYP4F2

MGVGPAVVAVLAVLLTPVLYLLISFLRVVAWSRRTGKVLEQFPGPTKHWLYGNLHQEDSKEAGKEEITESRRKLDFLDIL

LHAQDEDGNTLSDVEIRNQANTFMFA

(gap)

ATHPEHQERVYQEVKGILGGREPAHLEWEDLSNLKYLTLCIKEAMRLHCPVPII

GRQISAPIEVEGKVLEVGTITDVNIWNIHHNPTVWGDDHMEYDPSRFLPENMKDKDPYAFIPFSAGPRNCIGQNFAMNEE

KVLISRIIHKFKLEVVPDHPVEKVAEIVMKAKDGILLKVIPRT*

>fgenesh2_pm.scaffold_332000005|Brafl1 41% to CYP4T

89% to fgenesh2_pg.scaffold_195000012|Brafl1

MAVGPAVVAVLAVLLTPVVYLLVSFLRVVAWSRRTGRVLEQFPGPTKHWLYGNLHQYNLPKEEGLLQALEFAEKYGKVFR

LWWGPVRPCLTVVHPDTAKQILRKSDPKPGGAGYDLIIPWLGDGLILSKGAQWSRDRRLLTPAFHFEVLKPYVAVYNEGA

DILLKKLDTCSKSGESFETFSALSLCTLDIILRCAFSYQDDIQTKG

(gap)

KDFIFYLTKEGRDFKKLCAYVHQLADDIIAKRRQ

TLEDSKEAGKEDMTGSRRKLDFLDILLHAQDEDGNTLSDVEIRNQANTFMFAGHDTTASTTSWVLYSLATHNKHQERVYQ

EVQGILGERDHLEWEDLSNLKYLTLCIKEAMRLHCPVPIIGRQISAPIEVEGKMLEVGTITDVNIWNIHHNPTVWGDNHM

EYDPSRFLPENMKDKDPYAFIPFSAGPRNCIGQNFAMNEEKVLISRIIHKFKLEVVPDHPVEKVAEIVMKAKDGILLKVI

PRT*

 

$$$$$$$$$

 

>fgenesh2_pg.scaffold_18000173|Brafl1

MVFLGDVQRFTALIVDVVSWGVLTVTVVLLCQAAAAVWRSLQRVKLQEKVLPVPPGAHWLFGHTVIEKWEELGSGSSVDV

FHHLSLMTLDNMLKCALGQNTDCQTRKSNEYIAAVHELAQLTEKRGAHLSQYFLNDFLYINCLPAGKRYKKARDSAHRYS

EAIIQERRKTLDHPGSQDIHHGRKYLDFLDILLKAKDEDGNGLTDAEIRDEVDTFVFEGHDTTASGLAWTLYCLARHPGH

QEKCRKEAQEEFNPLRFAPENSKNRSPYAFLPFAAGPRNCIGQHFAMNELKTAVALILQRFSLTPDDTLPEPVPEISLVT

RVKPPGLFLQITAIN*

>e_gw.1011.10.1|Brafl1

95% to fgenesh2_pg.scaffold_18000173|Brafl1

LVGDGLLNSNGAKWFRNRRLLTPAFHFEVLKPYIRLFSESTNVMLEKWERLGSGSSVDVFHHVSLMTLDNMLKCALGQNT

DCQTRKSNEYIAAVHELAQLTEKRGARLSQYFLNDFLYIHCLPAGKRYKKARDSAHRYSEAIIQERKKTLDHPGSQDIHH

GRKYLDFLDILLKAKDEDGNGLTDAEIRDEVDTFVFEGHDTTASGLAWTLYCLARHPGHQEKCRKEAQEMLQGRTEVTWD

NLSSLKYITLCIKESLRMYPPVQRLFRQLEKPMTFFDGRTLPQGSNVYIGVRNLHYNPHVWDDPQEFNPLRFAPENSKNR

SPYAFLPFAAGPRNCIGQHFAMNELKTAVALILQRFSLTTDDTLPEPVPEISLVTRAKPPGLFLQITAIN*

>e_gw.1011.13.1|Brafl1

72% to fgenesh2_pg.scaffold_18000173|Brafl1

MAKEFPVPPGSHWLLGHMVLLGDEGRGLMLKAMEWSKIYKYAHVIRMGPLLQHCTVYHHDYVKAVMSRAGTKDDYAYSFL

RPWLGDGLLTSAGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNVMMKNWEELSGSSIDVFHHTSLMTLDSMLKCALSQH

TDCQTRKTNDYIAAVYDLADLTMKRGRSLLLRSDLIYALSADGKKYRKACNLVHEYAKRIIAERREALKQRLTEDDEETN

KKKYLDFLDILLKARDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLARHPGHQEKCRREAQEVLQGRTEVTWD

LLPSLKYITLCVKEVLRLFPPVPMIFRHLESPLTFPDGRTLPEGSRVGISTNTLHHNPHVWENPMEFDPLRFSPENAKKR

HPYAFIPFAAGPRNCIGQHFAMNELKTAVALILQRFRLTPDDTIPEPIPVPKLIMRAKKPGLFLKIKPLAA*

>fgenesh2_pg.scaffold_18000170|Brafl1 44% to CYP4F22

81% to e_gw.1011.13.1|Brafl1

MSLYQLGDEGEGLMLKFMEWSKIYKYAHVTRMGPLLQHCTVYHHDYVKAVMSRAVLSISYLQNNQNIQHWDTSSGDGLLT

SAGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNVMLNNWEELKSGSSIDVFHHTSLMTLDSMLKCALSQHTDCQTRKTN

DYIAAVFELTDLTMKRARTLLLRSDLIYALSADGKRYRKACNMVHEYAKRIIAERREALNHEDATNKKKNIDFLDILLKA

RDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLARHPGHQEKCRKEAQEVLQGETEVTWNCIGQHFAMNELKTA

VALILQRFSLTPDDTLPEPIPVPKLIMRAKKPGLFLKIKPITA*

>fgenesh2_pg.scaffold_18000171|Brafl1 44% to CYP4A11

87% to e_gw.1011.13.1|Brafl1

MAVTDALLSSGGNTVVTLTCCCAVVVLVVTLLKATVDLWRTVRCNRKMAVDFPVPPGGHWLLGHLVMLGPEGGELMLKGP

GWAEDYKYAHLMHSGPLLTHCSVYHPDYVKTVMARAGDGLLTSAGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNAMLT

NWEELKSGSSIDVFHHTSLMTLDSMLKCALSQHTDCQTSFLCYFYHIIRLKYLQDEDGNGLTDAEIRDEVDTFMFEGHDT

TASGLAWTLYCLARHPGHQDKCRREAQEVLQGGTEVTWDLLPSLRYITMCVKEAMRMFSPVPMIFRQLESPLTFPDGRTL

PEGAEYDPLRFSPENSKDRHPYAFIPFAAGPRKTNDYIAAVHDLTDLTMKRGRTIYHRVDLIYALSSDGRNFLCYFYHII

RLKYLQDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLARHPGHQEKCRREAQEVLQGGTEVTWDLLPSLKYIT

MCVKEAMRMFSPVPMIFRQLESPLTFPDGRTLPEGARVVIGINTLHHNSHVWENHMEYDPLRFSPENSKDRHPYAFIPFA

AGPRNCIGQHFAMNELKTAVALILQRFSLTTDDTLTEPIPVPKIIMRARKPGLFLKIKPLTA*

>fgenesh2_pm.scaffold_18000019|Brafl1 50% to CYP4F2

94% to e_gw.1011.13.1|Brafl1

MEWSKIYKYAHVIRMGPLLQHCSVYHPDYVKAVMSRADRKDDYVYSFLRPWLGDGLLTSAGPKWFRNRRLLTPGFHFEIL

KPYVRLFSESTNVMLKNWEELKSGSSIDVFHHTSLMTLDSMLKCALSQHTDCQTRKTNDYIAAVYDLADLTMKRGRTLLL

RSDLIYALSADGKKYRKACNLVHEYAKRIITERREALKQRHTQDDEEATNKKKYLDFLDILLKARDEDGNGLTDAEIRDE

VDTFMFEGHDTTASGLAWTLYCLARHPGHQEKCRKEAQEMLQGRTEVTWDLLPSLKYITMCVKEAIRLFPPVPMIFRHLE

SPLTFPDGRTLPEGSRVGISTNTLHHNPHVWENPMEFDPLRFSTENSKGRHPFAFIPFAAGPRNCIGQHFAMNELKTAVA

LILQRFSLTPDNTLPEPIPVPKLIMRAKKPGLFLKIKSLTA*

 

$$$$$$$

 

>fgenesh2_pg.scaffold_176000064|Brafl1 47% to CYP4F12

MATWMILPLAVIASVLLVQFVVSQVRQRRVTNQFVSPPSHWLYGHLMQLLPDESSWPVLKQMMRDYSSHVLQLWVGPFLP

LFIFCHPETSRAILSTSGDGLLLSHGSKWHRNRRLLTPAFHFEILKPYVTLFSQSTNVLIDKWTKLGSGCSVEMFEHVSL

MTLDSILKCSLSYHSNCQTDSQSSAYIRAVYDITRLFVERIRFPPYYSDFIYSLSPSGRRFYKACDLIHNFSENVIRERK

AQLAEVKKLGLPRRGKGKCLDFLDILLEARDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRG

EAEGLLQGRTEMSWEDMSKLPFTTMCIKESLRLRPPVPGIGRTLTQTLALPDGKKIPAGFQVLTGIMTAHRNPLIWPDPE

VYDPLRFSPENSKDRHSHAFIPFSAGPRNCIGQHFAMNEMKVAVALILQSFQLEPHGPPPFYEERIVLRARNGIWLKLHK

RE*

>fgenesh2_pg.scaffold_141000059|Brafl1

97% to fgenesh2_pg.scaffold_176000064

MATWMVLPLAVIVSVLLVQFVVSQVRQRRVTNQFVSPPSHWLYGHLMQLLPDESSWPVLKQMMRDYSSRVLQLWVGPFLP

LFIFCHPETSRAILSTSGDGLLLSHGSKWHRNRRLLTPAFHFEILKPYVTLFSQSTNVLIDKWTKLGSGCSVEMFEHVSL

MTLDSILKCSLSYHSNCQTDSQSSSYIRAVYDITRLFVERIRFPPYYSDFIYSLSPSGRRLYKACEVIHNFSENVIRERK

AQLAEVKKLGLPRRGKGKCLDFLDILLEARDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRR

EAEGLLQGRTEMSWEDMSKLPFTTMCIKESLRLRPPVPGIGRTLTQTLVLPDGEKIPPGFQVLTGIMTAHRNPLIWQDPE

VYDPLRFSPENSKDRHSHAFIPFSAGPRNCIGQHFAMNEMRVAVALILQSFQLEPHGPPPFYEERIVLRARNGIWLKLHK

RE*

 

$$$$$$$$

 

>e_gw.318.45.1|Brafl1 47% TO CYP4F2

MATEITVFSGGTVTASLWVFLVLIAVKLVTLVRKQREDALVLEKFPGPPRHWLLGHVHKVRMQLPGLQWADDMAAEYVYG

YPVWFGPVGYLNVTHPEYAKTILATTEPKDEFVYRFIKPWIGDGLLVSHGQKWFRNRRLLTPAFHFGVLQPYTHLFSDST

NIMMAKWRQLGAGASIDVFEHVSLMTLDSMLKCALTVESNCQVDRKQNSYIAAVFSLTKLALQRFHLFPLHSDLIYYLTP

MGYRFWKLCKVVHQHSESVIRDRREALKKEQVQDSGQRRKYLDFLDILLKTKDEDGNGLSDVEIRDEVDTFMFEGHDTTA

SGLSWTLYNLARHPEHQERCRQEARSVLQGRSVVTGTDLSHLPYITVCIKESLRLHTAVPSIARKLTKSVTFPDGKSLPP

GSLVGISVWNIHHNPHVWRDPKVYDPSRFLPENCKGRHSHAFIPFSAGPRNCIGQHFAMNELKTAVALIVQSFRLSVDEN

HVAKGVMSLVLKAADPGLFLKVTPLD*

>e_gw.28.111.1|Brafl1

97% TO e_gw.318.45.1|Brafl1

MATEITLFSGGAVTASLWVFLVLIAVKLVTLVRKQREDARVLEKFPGPPRHWLLGHVHKVRMQLMSLQWADDMAAEYVYG

YPVWFGPVGYLNVTHPEYTKTILATTEPKDEFVYRFIKPWIGDGLLVSHGQKWFRNRRLLTPAFHFGVLQPYTRLFSDST

NIMMAKWRQLGAGASIDMFEHVSLMTLDSMLKCALTVESNCQVDRKQNSYIAAVFSLTKLALQRFHLFPLHSDLIYYLTP

MGYRFWKLCKVVHQHSESVIRDRREALKKEQVQDSGQRRKYLDFLDILLKTKDEDGNGLSDVEIRDEVDTFMFEGHDTTA

SGLSWTLYNLAKHPEHQERCRQEARSVLQGRSVVNSTDLSHLPYITVCIKESLRIHTAVPSIARKLTKSITFPDGKSLPP

GSLVGISVWNIHHNPHVWRDPKVYDPSRFLPENCKGRHSHAFIPFSAGPRNCIGQHFAMNELKTAVALIVQSFRLSVDEN

HVAKGVMSLVLKAAEPGLFLKVTPLD*

 

$$$$$$$

 

>e_gw.41.29.1|Brafl1 51% to CYP4V2

WKIINKIPGPPAYPLVGNVLEFKTDPATFFPQLTGWLQDYTNANAPMMYLWLGPHPMVWLLQTETFEVLFNSSKHITKSR

EYDFLHPWLGTGVLTSTGDKWKTRRRLITPTFHFKILNDYLQEFNDQSEIMVRKLEKMAGTGKEFDVHPFITFCALDIIC

GTAMGKSLNAQDNPETDYVRAIKKMTDFIQLRQKSPWYWSDVVFKNFGPGREFDETLQILHGFTGSSQSQAASDIVEDPD

KPVAIGGRKRLAFLDMLLYASVGETKLTNEDIQEEVDTFMFEGHDTGSAAACWSIFLIGSHPDVQKKVQEEMDRVLSDTD

QKPTMDDLRQMKYLECCMKEALRLYPPIPLFGRTLSEDCVIGGYEVPKGVTASISCYNVHRNPKHWPDPEKFDPERFFPE

NCDGRHPYAFIPFSAGIRNCIGQKFAFVEEKALLSSIFRRFRIETVQKREELKPMGDVVLRPENGVWIKLHHRE*

>fgenesh2_pm.scaffold_41000001|Brafl1

76% to e_gw.41.29.1|Brafl1

MAAVLWTAAVAVAVSVTIWAIFAFARWWKLWKTINKIPGPPAYPLVGNALEFKPGAVEFFAQLFGWGKAYASAPVLRWWI

GPHPMVALHHPEMLQVLFSSSKHIEKSFVYDFLHPWLGTGLLTSAGDKWKTRRRLITPTFHFKILGDFLHEFNDQSEIMV

RKLEEMAGTGEEFDVFPFITLCALDIICGTAMGQSLNAQENTDSDYVRAIYRISDLIQVRQKSPWYWSDPIYKGFGPGRE

FEETLRILHDFTRSVIKERSEQFQKQLESQSQDAFDIVEDPDKPIAIGGRKRLAFLDMLLYASVGETKLTNEDIQEEVDT

FMFEGHDTTAAAANWAIFLIGSHPDVQRKVHEEMDRVMSDPDEKPTMDDLREMKYLECCIKEALRLYPSVPFFARTLSED

CVIGGYEVPKGVTAIVPTYNVHRDPNHWPDAEKFDPERFFPENCAGRHPYAYIPFSAGSRNCIGQRFALMEEKAILSSIF

RRFRIETMQNREDLKPLGELILRPESGVRIKLFRRE*

>e_gw.59.33.1|Brafl1

77% to e_gw.41.29.1|Brafl1

WKTINKIPGPPAYPLVGNALEFKPGAVDFFDQLCVVGHELFKQYILVRVWLGPVPVIGLNRPETVEVLFSSSKHIEKSFV

YDFLHPWLGTGLLTSAGDKWKTRRRLITPTFHFKILGDFLHEFNDQSEIMVRKLEEMAGTGEEFDVFPFITLCALDIICG

TAMGQSLNAQENTDSDYVRAIYRISDLIQVRQKSPWYWSDPIYKGFGPGREFEETLRILHDFTRSSQSQDAFDIVEDPDK

PIAIGGRKRLAFLDMLLYASVGETKLSNEDIQEEVDTFMFEGHDTTAAAANWAIFLIGSHPDVQKRVHEEMDRVMSMSQY

KPTMDDLREMKYLECCIKEALRLYPSVPFFARTLSEDCVIGGYEVPKGVTAIVPTYNVHRDPNHWPDAEKFDPERFFPEN

CAGRHPYAYIPFSAGSRNCIGEKIYHDSV*

 

$$$$$$$

 

>fgenesh2_pg.scaffold_422000011|Brafl1 47% to CYP4F12

MLLSLPQDRLLSLEEKDRCSVWRLGPFLPVLSCSHPDTVRPILGGKTQKTSWVYGFFRPWLGDGLLISEGQKWQRNRRLL

TPAFHFDILKHYVTLFSESTQVLLEKWLSRGPGASVELFDQIGLMTLDNILKCSLGYHSNCQTDGQSAPYIQAVHDLTSL

IDERVDRPLQHIDFIYYLTAKGRRFRQACKVVHSFSEQVIMTRKEERKKEELKEEDFTSPGYKSGKCLDFVDILLQAKDE

DGTGLSVSEIRDEVNTFLFAGHHTTASGVSWTLFYLAQHQDYQDECRREAEGVLEGRTEITWHDVGKLPFLTMCIKESLR

CVPPVARSARTLQLDLTFADGKWLPKGTSAVADFPGLHRNSEIWENPTVYDPYRFSPENSERRPPHAFLPFSAGPRNCIG

QNFAMNEMKVTLALTLQRFRLEPDVTKPPVIPCDGITLQARGGIWVKVHPLKTNT*

>e_gw.499.34.1|Brafl1

95% to fgenesh2_pg.scaffold_422000011|Brafl1

VWRLGPFISVLSCSHPDTVRPILGGKTQKTSWVYGFFRPWLGDGLLISEGQKWQRNRRLLTPAFHFDILKHYVTLFAEST

QVLLEKWLSRGPGASVELFDQVGLMTLDNILKCSLGYHSNCQTDGQSAPYIQAVHDLTSLIDERVDHPLQHIDFIYYLTS

KGRRFRQACKVVHSFSEQVIMTRKEERKKKELKEEDFTSPGYKSGKCLDFVDILLQAKDEDGTGLSVSEIRDEVNTFLFA

GHHTTASGISWTLFYLAQHQDYQDKCRREAEGVLEGRTEMTWRDVGKLPFLTMCIKESLRCVPPVARSARTLQQDLAFAD

GKWLPKGQLDFPDFPGLHRNSEIWENPTVYDPYRFSPENSDRRPPHAFLPFSAGPRNCIGQNFAMNEMKVTLALTLQRFR

LEPDVTKPPVIPCDGITLQARGGIWVKVHPLKTNT*

>e_gw.110.96.1|Brafl1 50% to CYP4T

74% to fgenesh2_pg.scaffold_422000011|Brafl1

AQKTEWMYRFFRPWLGDGLLLSDGPKWQRNRRLLTPAFHFDILKHYVQLFSESTAVLLDKWMSRGPGASVELFDHIGLMT

LDNILKCSLGYNSRCQTDGQSAPYVLAVHDLTKLIEDRPDKLSNHIDFIYYLSKDGRRFRRACKIVHSFSAQVIKERNEE

LKKKDSSFKSGKCLDLLDILLKAKDEDGTGLSVSEIQDEVNTFLFGGHHTTASGISWTLYHLAKHKDYQDKCRREVEGVL

HGRAEMTWHDVGQLSFITMCIKESMRCVPPVPRVARSLKQDLTFVGGKWLPMGSPTMTDIAGTHRNRDIWPNPTVYDPYR

FSPENSANRHPYAFLPFSAGPRNCIGQNFAMNEMKVSVALILQRFQLELDETKPPAVPFDSLTVQAKDGIWVKLHPVKTD

T*

>e_gw.267.107.1|Brafl1

69% to fgenesh2_pg.scaffold_422000011|Brafl1

MDHNDRYRVFWVTPFLPITYGIHPSTARSILSSKSDIIPSTPCFCTLYVGDGLLLSDGYKWQRNRRLLTPAFHFDILKHY

VQLFSESTAVLLDKWMSRGPDASVELLDDIGLMTLDNILKCSLGYNSRCQTDGKSAPYILAVNDLTRLFAERGDQPLHYF

DFIYYLSSDGRRFRKACKVVHSFAEQVIKARKEELKKGGGTLPKPRGGKCMDLLDVLLQAKDKDGTGLSVSEIQDEVNTF

LFAGHHTTASGISWTLHHLAKHKDYQDKCRREVEEVLRGRAEVTWHDIGKLPFITMCIKESMRCVPPVRRLARTLKQDLI

FSDGKSLPKGSTTFVDFGDLHRNRDVWPNPKVYDPYRFSPENSENRHPHAFLPFSAGPRNCIGQNFAMNEMKVSVALILQ

RFQLELDGTKPPAVPCTRVTNQAEDGIWVKFHPAKTNT*

>fgenesh2_pg.scaffold_208000076|Brafl1 59% to CYP4F8

94% to e_gw.267.107.1|Brafl1

MLTARAHEYRQFEMVASAEDEQSHASNFLRLLSARLPAGVTGTTLVMWTVVLVLAVRLSVYMANFIAWQDGLLSMDHNDR

YRVFWVTPFLPITYGIHPSTARSILSSKTQKPSYGYAYFRPWLGDGLLLSDGPKWQRNRRLLTPAFHFDILKHYVQLFYE

STAVLLVYDPYRFSPENSENRHPHAFLPFSAGPRNCIGQNFAMNEMKVAVALILQRFQLELDHTKPPAVPCTRVTNQAED

GIWVKVHPLKTKT*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_203000045|Brafl1 38% to CYP4F12

MTRDVVEKHARAHTYWAGLFNVVVVTHPETIRQLLRSQSEKGSVYGSLRPWLGNGLFLSDGDQWRVHRRLLTPAFHFDIL

KQYVSVYNKEATEMISKLSETAKIRHAFEMFQEASMCTLEIILQCAFSGGQMSDETKNEYVAAIRKLKLLFVEMQFNPIY

WLSVSAYNRLPSGREYIRLCKSIQDKAGSIITKRRQQQNRNGRPGQNTRLDFIDILLSARHEDGTGLTDLEIREEDKVRE

EVNHLLSGREDDTIQWADLHKLPYLTMCLKEAMRLHTPVPMITRATLEDTVIDGVTVPKGFDIGIHLYGLHHNPAVWGPD

HMEFDPSRFRPERMKDRDSHAFLPFSAGQRNCIGQNFAMNEAKVLLARLIHKFVFEVDPTRPAQKEMLIVMCAKGGMWME

VTPA*

>fgenesh2_pg.scaffold_200000054|Brafl1 375 to CYP4F43

75% to fgenesh2_pg.scaffold_203000045|Brafl1

MTSLLGLHDTTSLLVGLLLPVVLYGLVVVVRYLLKRWKSIRLGSSFPSPPYHWLYGNNHLTDYTWGEKYLSMIRDAVEKH

PQAHSYWMTGYSKIIHLTHPETIRQMLKSQSNGLFLSDGDQWKVHRRLLTPAFHFDVLKQYVSVYNREATEMISKLSGTT

GNGQVFEMFQEASMCTLEIILQCAFSGGQMPDETKNEYVAAIRKLKLMFLKMLFNPLFLLSASAYRRLPNGREYTRLCTF

IHDTAESIVTKRRQQLMRDGRPQQKARPDFMDILLSARYEDGTGLTDLEIREEVDTFLFAGHETTASALSWTLYSLAQHP

HHQDKVREEVNHLLARREDDAIQWEDLSKLPFLTMCLREAMRLHSPVPLVMRTMLEDTVIDGVTVPQGFSVAIHLYGLHH

NPAVWGPDHMEFDPSRFRPERMKDRDSHAFLPFSAGQRNCIGQNFAMNEAKVLLA

RLIHNKDDDENTSRNEGCTSQCFHR

FTQWTSGCLSRLSRGALRCPKTCGQWVWGNRWIQWFGTNVFTLIGAAAFMLYIVTYLVCLGNWLEIRNYQHPTNVSSNDT

HLVLCNPEEAQIMLPYMLINFMVYALPWVAIVHWQKYGNAGKLKSWEAKFKELSRNSVDFREGIRDSRHFSMCLHFFVCF

ILSEVNGSLKCATCHGQKGLKWTISYFAHSIDYDLYFSGCFFVQLTYFTALFIPYILYCKYATDLMYAIDCRIWYLRYVK

HEWFGKKTSPSEILQNVNPNLRKDGWHAEIGSIANFFMTMMICVAYILVVVYCHIYFSANPPLLDWTHNVTQVLHNAAMP

IIPFLFILSSASRHQEENENLVSEAASAYADARLQALCQIENYTDAAKYTLKQWKEIVKVLNDSKAYVVHSNLLSSHVFF

AVVMSERDPLLSAGTGGSVNNDQSENLPSLPSRNENCFHRFTQRMKEKVGNVILWLREKVGNVILWLKEKVGNVILRLIE

NVKKVFLWLLTYVVTAVGLVAFLFYIGTYLYCLGNWLDIRNRPHPTNVSSNDTHVVLCNPEEAQIMLPYMLISFMVYALP

WVAIVHWKINGNADKLKKWADEFEKKFHDSGDFRESEKIRDSRHFSMCLHFFICFILSSVNGSMKCATCDGQKGLKWTIS

YIAHRVDTDFYVYFSLCFFVQLTYFTFLFIPYILYCQYATDLMYAIDCRIWYLRYLQHKWIDKRTPPGEILQNIKPNLRK

DGWHAEIGSIASFFMTMMICVAYILVVIYCHIYFSANPSSVRLDPQCHSDSSQRPPCPIIPVLVHPVQGFQASRAERRLNF*

>e_gw.335.24.1|Brafl1 49% to CYP4F43

97% to fgenesh2_pg.scaffold_200000054|Brafl1

EDLQKLPYLTMCLREAMRLHSPVPLVMRTMLEDTVIDGVTVPQGFSVAIHLYGLHHNPAVWGPDHMFDPSRFRPERMKDR

DSHAFLPFSAGQRNCIGQNFAMNEAKVLLARLIHK*

>fgenesh2_pg.scaffold_112000079|Brafl1 42% to CYP4T

92% to fgenesh2_pg.scaffold_203000045|Brafl1

MFQEVNMCTLEVILQCAFSGGQMSD EHVLPFDNVKSWTSQQCFSACSCVC

SNPIYQLSSSAYNWFPSGREYTRLCKFIHD

TAESIIAKRRQQLKRNGRSQRNTRLDFIDNLLSARYEDGTGLTDLEIREEVDTFLFAGHETTASALSWTLYSLAQHPHHQ

DKVREEVNHLLSGMEDDTIQWEDLHKLPYLTMCLKEAMRLHTPVPIIVRSMLEDTVIDGVTVPKGFEIYISLYGLHHNPA

VWGPDHMEFDPSRFCPERMKDRDSHAFLPFSAGQRNCIGQNFAMNEAKVLLARLIHK*

>fgenesh2_pm.scaffold_17000025|Brafl1 44% to CYP4F2

94% to fgenesh2_pg.scaffold_112000079|Brafl1

MFQEVNMCTLEVILQCAFSGGQMSD

(gap)

DNPIYQLSSSAYNWLPSGREYTRLCKFIHDTAESIIAKRRQQLKRNGRSQRNTRL

DFIDILLSSRYEDGTGLTDMEIREEVDTFLFAGHETTASALSWTLYSLAQHPHHQDKVREEVNHLLSGMEDDTIQWEDLH

KLPYLTMCLKESMRLHTPVPIIVRSMLEDTVIDGVTVPKGFEIYISLYGLHHNPAVWGPDHMEFDPSRFCPERMKDRDPH

AFLPFSAGQRNCIGQNFAMNEAKVLLARLIHKFVFEVDPTRPAQKEVLIVMCAKGGMWMKVTPA*

 

$$$$$$$$

 

>fgenesh2_pg.scaffold_18000175|Brafl1 37% to CYP4F12

MSSDNASNTLGFLSRHVFTTALWCAAALCVVVLLKGTVAVVRSLRNLWALEKVFPVPPRAHWLLGHMVFLSQGDRHIHEI

TSEWFRQYQRGYIFRHGAAMGRLVVTHPDDVRAVLMRTGDGLLLSSGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNVM

LDNWKDLKPGSSIDVFHYLSLMTLDSMLKCTLSQNTNCQTRHKAACSTVHKYSEEIIRQRKNALKKQSDGDRAKKYLDFL

DILLRAKDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLARHPGHQEKCRKEAQEVLQGRTEVTWEDLPSMKYI

TLCVKESLRLYPAVPEILRTVETPLTFSDGRTVPEGKPYPKEYDPLRFSPENSKGRHAYAFVPFSAGPREDLPSMKYITL

CVKESLRLYPAVPEILRTVETPLTFSDGRTLPEGSQVYINLRLLHRNPHIWEKPEEYDPLRFSPENSKGRHAYAFVPFSA

GPRNCIGQHFAMNELKTAVALILQRFSLTPDDTLPEPVVLDRMVLRADSPGLYLKITPIEME*

>e_gw.567.63.1|Brafl1 47% to CYP4X1

85% to fgenesh2_pg.scaffold_18000175|Brafl1

EDLPSMKYITLCVKESLRLYPAVPEILRTVETPLTFSDGRTLPEGKLNTPVTLRENRSAYNPLRFSPENSKGRHAYAFVP

FSAGPRNCIGQHFAMNELKTAVALILQRFRLTPDDTLPEPVVLDRMVLRADSPGLYLRITPIEME*

>fgenesh2_pg.scaffold_18000176|Brafl1

79% to fgenesh2_pg.scaffold_18000175|Brafl1

MSPDNASNILGFLSRHVLTTALWCAAALCVAVLLKGTAAVVRSLRNLWALEKVFPVPPGAHWLLGHLVLLRQGERHNREI

TSEWFRQYQHGYIFKHGAAMGRLVATHPDDVRAVLMRTGDGLLLSSGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNAM

LNNWKELKPGSSIDVFHHMSLMTLDSMLKCTLSQNTNCQTRHKAACNIVHKYSEEIIRQRKEVLKQQSAGDSTYGKKYLD

FLDILLRAKDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLARYPGHQDKCRKEAQEVLQGRTEVTWEDLPSMK

YITLCVKESLRMYPAVPEILRDVETPLTFSDGRTLPEGSQVYISLRLLHRSPHIWEKPEEYDPLRFSPENSKGRHPYAFL

PFSAGPRNCIGQHFAMNELKTAVALILRRFSLTPDDTLPEPFPVERMILRADSPGLYLRITPIEMD*

>fgenesh2_pg.scaffold_18000174|Brafl1

86% to fgenesh2_pg.scaffold_18000175|Brafl1

MSDNASNTLGFLSRHVFTTALWCVVVLCVAVLLKGTVAVVRSLRNLWALEKVFPVPPGAHWLLGHLVFLRQDARHSYEIT

AEWFRQYQQGYIFKHGAAMGRLVVTHPDDVRAVLMRTGDGLLLSSGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNVML

NNWKELKPGSSIDVFHHMSLMTLDSMLKCTLSQNTNCQTRNRAACNIVHKYSEEIIRQRKEVLKQQSAGDSTHGKKYLDF

LDILLRAKDENGNGLTDAEIRDEVDTFVFEGHHTTASGLAWALYCLARHPGHQEKCRKEAQEVLQGRTEVTWEDLSSMKY

ITLCVKESLRLYPAVPEILRDVETPLTFSDGRTVPKGSQVYISMRFLHRNPRIWEKPEEYDPLRFSSENSKGRHPYAFLP

FSAGPRNCIGQHFAMNELKTAVALILQRFILTPDDTLPEPFPVERMVLRADSPGLYIKITPFEVE*

>e_gw.567.49.1|Brafl1 45% to CYP4F22

82% to fgenesh2_pg.scaffold_18000175|Brafl1

AALCVAVLLKGTVAVVRSLRNMWALEKVFPVPPGAHWLLGHLVFAKQGDRHIQKAMSEWVQQYHQHGFIFKHGAAMGRLV

ATHPDDVRAVLMRTDQKLEIIYGMLRPWLGDGLLLSSGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNVMLSKLYTQNN

WKELKPGSSIDVFHHLSLMTLDSMLKCTLSQNTNCQTRKTNDYLSSIHELTELAMQRGRSIIYLLSDFVYGLSSSGRRHK

AACNIVHKYSEEIILQRKEVLKQQSAGDSTHGKKYLDFLDILLRAKDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWT

LYCLARHPGHQDKCRKEAQEVLQGRTEVTWEDLPSMKYITLCVKESLRLYPAVPEILRDVETSLTFSDGRTLPEGSQVYI

SLRLLHRSPHIWEKPEEYDPLRFSPENSKGRHPYAFLPFSAGPRNCIGQHFAMNELKTAVALILQRFSLTPDDTLPEPFP

VERMILRADSPGFYLRITPIEMD*

>fgenesh2_pg.scaffold_41000050|Brafl1 49% to CYP4A11

72% to e_gw.567.49.1|Brafl1

MKVVQISNHKQYGDGLLTTSGAKWFRNRRLLTPGFHFEVLRPYVKLFSDSTNVMLENWEEFGAGASIDVFQHVSLMTLDS

MLKCALSQNTGCQKRKKFNSYISAIHEISELFMARALSIMAIVSDFVYNNSSAGKRYKKACNEVHQFSEKIIQQRKQDLD

NLSTTETTRRQKYLDFLDILLMAKDEDGNGLTNTEIRDEVDTFMFEGHDTTASGLAWTLYCLARHPGHQEKCRKEAQEVL

QGRTDVTWEDLPSMKYITMCIKESLRIYPPVPKILRELEEPLTFPDGKTVQKGTTVFIGLQLMHLNPNVWERPEEYDPLR

FSPKNSSSRHPYAFLPFSAGQRNCIGQHFAMNELKTAVALILQRFRLTPDDSLQEPVPVHKIVLRADSPGLFLKINPL*

>e_gw.1011.9.1|Brafl1

74% to fgenesh2_pg.scaffold_41000050|Brafl1

MIVLFRLNSTDQKLEIFYGMLRPWLGDGLLLSSGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNVMLNNWKDLKPGSSI

DVFHHTSLMTLDSMLKCTLSQNTNCQTRKTNDYLSSIHELAELAIQRARSIVYLLSDFVYGLSSSGRRHKAACNIVHKYS

EDIIRQRKDALKEHSAGDSVKKYLDFLDILLRAKDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLARHPGHQE

KCRKEAQEVLQGRTEVTWEDLPSMKYITLCVKESLRLYPAVPEILRDVETSLTFSDGRTVPQGRSQVYISLRLLHRNPHI

WEKPEEYDPLRFSPENSKGRHPYAFLPFSAGPRNCIGQHFAMNELKTAVALILQRFSLTPDDTLPEPFPVERMVLRADSP

GLYIKITPFEIE*

>e_gw.1011.3.1|Brafl1 52% to CYP4T

91% to e_gw.1011.9.1|Brafl1

GDGLLLSSGPKWFRNRRLLTPGFHFEILKPYVRLFSESTNAMLNNWKELKPGSSIDVFHHLSLMTLDSMLKCTLRQNTNC

QTRQTNDYLSSIHELAELTVQRAKSIVYLLSDFVYGLSPSGRRYKSACNIVHKHSEEIIRQRKDALKEQSAGDSAKKYLD

FLDILLRAKDEDGNGLTDAEIRDEVDTFMFEGHDTTASGLAWTLYCLACHPGHQEKCRLEAQEVLQGRTEVTWEDLPSMK

YITFCVKESLRLYPAVPEILRTVETPLTFSDGRTLPEGSQVYINLRLLHRNPHIWEKPEEYNPLRFSPE

 

$$$$$$$

 

>fgenesh2_pg.scaffold_148000001|Brafl1 28% to CYP4F43

MTSSVLGLPYQLHSTAFSMLQHLYRQLNAAVDWSTLLVALCTWLIVVLTYKLFLRPLYFSPLRVMPSPKYNPILGQMWEI

IHEEAVVPTLRRARKLGPISRYFFLFGGERVLVAEPDALKHILVTNHANYVRPAFITRAFANLADKGLLAVSGAEHAMQR

KILNPAFKRENLKGTCTNDKRMVKTFQEWTEVLVQYWNDKLEGTTTTDEFVELPVQDDMGRLTLDIIGKCAFSYEFNSIR

EPDNLVSQSVTKLLRGEGTGLLTLITGSRIGTSKEFVKRRALCDQIVDDVIAERKRLYANPEQVDDNVPSDLLSLVMLAR

DRDTGEGLPEEVIRHEVMTFMVAGHETTSTGLSWLLLELSRHPEIQDRLRSEVRAVLPGDDTPITWDLLDQIPYLMWVVK

ETLR

XXXXXXXXXX

QALQDDRLGQYPIPAGTVVNISPAVMHRS

ALSNPTHIIYKDWQISICEGTR*

 

>fgenesh2_pg.scaffold_193000039|Brafl1 39% to 4F43

97% to fgenesh2_pg.scaffold_148000001|Brafl1

MAELRPVFILVVFFTCLTGTEQGIRCPLGYNPCGQAYPCILAWKRCDGRADCTDGRDEEGCACLPIPVDLNLGGLLAMLP

NQLGQTTFEEILNSSAVVLLNSSTSHAENRHPEFLEFASAVIFPRCVLSEESNTSCSSSQHGDNSTSCMGTQMLPCRSWC

EEVLHMADDPVKNLFPTCDLFPSPPHACWNPEPETNSDEVCYHGNGMNYRGTWSKTTSGADCVEWSAAQAGFYPTEYPWA

NLKNNYCRNPTGQERPFCLVEDGSQEECDVIPCNLDACLGDPCGILATCTDNPPPALNATCTCNTGYAGDGLVSSIGCTG

CPSGYTAHKDSCFKAYNQGKTYNQARHVCAADRGLLAMPKDEDADDFLNALNPNSPFWFGMSDQSGEGGWMWEDGTPYST

VADWPNGGWQPGEPNNVGEGKVCASHFRTGWNDAPCSTARNFICQLNNAFHCPLRYLQCAHGHACILAWQRCDGRTDCTD

GSDEEGCVCLPIPVDLNLDSRLAMLPNQLGQTTFEEIQNSSAVELLNRSTSHAENRHPEFREFAAVVIFPRCAISEEYNT

SCSSSQHGDNTTSCITQLAPCRSWCEEVLHMADDPVKNRSPTCDLFPSPPHACWNPEPETKNNEVCYHGNGLNYRGTWSK

TTSGADCVEWSAAQAGFYPTEYPWANLKNNYCRNPTGQERPFCLVEDGSQEECDVIPCNVVGCWDLGPPNYGKRIPVKRF

YNVGEKVSYTCDVGYSLENGSDSETWQDSRLKWDPKYYRSLDTLSVSASSIWTPAFTLKANGDPGYAGLPKEVPVLLSTE

GTVTWRVETLTSTICDADPFLFPADTMDCHICFSVSSAIKHTIECGEGSTCDGWFPPQQEGEWDRRDRIFAEGNKTACLA

VHLERIPMFHIATTVAPCAILVVLMIITFIMPIDKGDRIAYGVTIMLSVVVSLVFVTEVLPVKGALPFFECGEGSTCDGW

FPPQQEGEWDRRDRIFAEGNKTACLAVHLERIPMFHIATTVAPCAILVVLMIITFIMPIDKGDRIAYGVTIMLSVVVSLV

FVTEVLPVKGALPFFEKKALLDFQGDAPLGKGMFLPLLGDAPPEMFFSFILKLTILPIT

TLDIIGKCAFSYEFNSIREPDNLVS

QSVTKLLRGEGTGELLFKFFLVDDNIPN

DLLSLVMLARDRDTGEGLPEEVIRHEVMTFMVAGHETTSTGLSWLLLE

LSRHPEIQDRLRSEVRAVLPGDDTPITWDLLDQIPYLMWVVKETLRQALQDDRLGQY

(gap)

PIPAGTVVNISPAVMHRLSQYWE

DPDTFKPERFAGDSNRNPYTFLPFIAGPRTCIGSKFALAEMRAVTAVLVRHFQFDPVPGVEYKNKQRITMRPEPPLCLRV

SKTLL*

 

>estExt_fgenesh2_pg.C_30039|Brafl1 31% to 4F43

78% to fgenesh2_pg.scaffold_148000001|Brafl1

MLQHLYRQLNAAVDASTLLLALCTFLAVFLSYKLFLKPLYFSPLRVMPSAKFIPIVGQIWDINRQQAIVSDLRRARKLGP

ISRYFVTFGEERVMIADPDAMKHILVTNHANYVRPYLLRSAFAALAEKGLLAVSGTEHAMQRKILNPAFKRENLKGMVKT

FQQWTEVVVQYWNDKLEGTTTSDGFAELPVQDDIGRLTLDIIGECAFSYEFNSIREPDRLVNQSVTRLLQDSGASWITVV

TAGSVFVATKEFLKLRGLCERIVDDVIAERKQLQENPEQADDDAPNDLLSLVMMARDRDTGEGLPEEVIRHEVMTFMVAG

HETTSAGLAWLLLELSRHPDIQDRLRSEVRDVLPSDDTPITWDLLDQIPYLMWVVKETLRLHPPAPQTFRQALKDDRVGQ

YPIPAGTIVKMSPAVIHRLSEYWEDPDTFKPERFAGDANNRNPYTFLPFIAGPRTCIGSKFALAEMRAVTAVLVQHFQFH

PVPGVECKNKHGITMRPEPDLCLRVSKAPA*

 

>estExt_gwp.C_5870041|Brafl1 43% to CYP4F12

98% to estExt_fgenesh2_pg.C_30039|Brafl1

MARDRDTGEGLPEEVIRHEVMTFMVAGHETTSAGLAWLLLELSRHPDIQDRLRSEVRDVLPSDDTPITWDLLDQIPYLMW

VVKETLRLHPPAPQTFRQALKDDRVGQYTIPAGTIVKMSPAVIHRLSQYWEDPDTFKPERFAGDANNRNPYTFLPFIAGP

RTCIGSKFALAEMRAVTAVLVQHFQFHPVPGVEYKNKHGITMRPEPDLCLRVSKAPA*

 

>fgenesh2_pg.scaffold_193000042|Brafl1 green = 41% to CYP4F12

83% to estExt_fgenesh2_pg.C_30039|Brafl1

MLARDRDTGEGLPEEVIRHEVMTFMVAGHETTSTGLSWLLLELSRHPEIQDRLRSEVRAVLPGDDTPITWDLLDQIPYLM

WVVKETLRQALQDDRLGQYPIPAGTVVNISPAVMHRLSQYWEDPDTFNPERFAGDANRNPYTFLPFIAGPRTCIGSKFAL

AEMRAVTAVLVRHFQFDPVPGFVSKKLGVDPTTWGYLQTTIAVAQLAGCPIFGRFGDLYGGRAAMTLTFLGMMVESLLVA

MAFSGGIPLLFISRAPMLFIHPMTAFQMVASDLSDEKTRADALAKLNIVSTVGRILGPTIAGWLVEHYGESFTCVAAASL

SAVCVALVLVFIPVSTKQVNEEKVETSSQKKTSLFDYREILRLLRIPAVAELLGIKMFCSVAFFLLNSMMPIIQMEVFNM

SPQEYGYFGTYLGIVYLICFSCVSPLTKRLSDINVMRFSEILVTIGDFGLALSNNYWQAGLAFLPRCFGDGILATMINSG

LSKGVSAQDTGGVMGLSLSAGHVPHMITPPIAAYLFETFGYRSIGIGCFAINSAMTVYLLRRKDAPST*

 

$$$$$$$

 

>fgenesh2_pg.scaffold_152000001|Brafl1 two genes fused

35% to CYP4F8

MKTGVSPVDVAVGLLVPVAAYLLFVVAKFLRKYWRDFNVGRQFPSLPYHWLYGNTHLTDGHFGEKYLSSTLDLMKKHPHA

QTFWLSGFMPLPILTHPVTIKQLLKASSNGLIMSTGDVWKVHRRLLTPAFHFDILKQYVSVYNRAAEHMIHLIFLSRHSS

RTKNEYVEAVKRIGILQVERNFNPLYMVFDTIFYLSPGGREFLRLCDFVHDTGGSIIKRRRQELEHNSEILAEKKRLDFI

DILLMARDEDGRGLTNLEIREEVDTFLFAGHDTTASTLSWALYSLAQHPHHQDKVREEVDQLLASREEDTIQWEDLHKLP

YLTMCLKEAMRLHSPVPFISRTVTEDTVIDGVHIPEGSYIGIHLYALHHNPDIWGDQHMDFDPSRFHPDRMKDMDSHAFM

PFSAGQRNCIGQNFALNEEKVILARLLHKKEVRQGNPQP

DIMMTSVSPVDVAVG

38% to CYP4F8

LLVPVAAYLLFVVAKFLWNYWRLFRV

ERQFPSPPYHWLYGNMHLTDGYLGERYLSMIREVVRKHPHAHSFWLAPFLTAIHITHPVTIKQLLKTSSNGLIVSTGDVW

KVHRRLLTPAFHFDILKQYVSVYNRAAEHMIEKLSKYSGKEDSFEMFHQASLCTMEVILQCAFSGGEMSEQTKNEYVEAV

KRIGILLVERNFNPLYVLFTAIYNLSPGGREFLRLCDFVHDTGGSIIKRRRQELERDPESLAEKKRLDFIDILLMARDED

GRGLTDLEIREEVDTFLFAGHDTTASTLSWALYSLAQHPHHQDKVREEVDQLLADREEDAIQWEDLHKLPYLTMCLKEAM

RLHSPVPFISRTVTEDTLIDGVHIPEGSYIGIHLYALHHNPDVWGDQHMEFDPNRFHPDRMKDMDSHAFMPFSAGQRNCI

GQNFALNEEKVILARLLHKFTFDLDPARPVEKDMTVVMKTRDGMWMKVKSTGQTAD*

 

>e_gw.333.45.1|Brafl1

37% to CYP4F22

EKYLSSSVDLMKKHPHAQTFWLSGFMPLPILTHPVTIKQLLKASSTYFYVSLNKSMFVPLPGNGLIMSTGDVWKVHRRLL

TPAFHFDILKQYVCVYNRAAEHMMEKLSQYTGREDSFEMFHQASLCTMEVILQCAFSGGEMSEQT

KNEYVEAVKRIGILQ

97% to fgenesh2_pg.scaffold_152000001|Brafl1

VERNFNPLYMVFDTIFYLSPGGREFLRLCDFVHDTGGSIIKRRRQELEHNPEILAEKKRLDFIDTLLMARDEDGRGLTDL

EIREEVDTFLFAGHDTTASTLSWALYSLAQHPHHQDKVREEVDQLLAGREEDTIQWEDLHKLPYLTMCLKEAMRLHSPVP

FISRTVTEDTVIDGVHIPEGSYIGIHLYALHHNPDVWGDQHMFDPSRFHPDRMKDMDSHAFMPFSAGQRNCIGQNFALNE

EKVILARLLHK

FTFDLDPARPVEKDMIVVMKTRDGMWMKVKSTGQTDD*

 

>estExt_fgenesh2_pg.C_3330005|Brafl1

MTTSVSPVDVAVGLLVPVAAYLLFVVAKFLWTQWWQFRVGQQFPSPPYHWLYGNMHLTGGYLGERYLSMTREVVRKHPRA

HSFWLAGFIVGVNVAHPATIKQLLKTSTKKSADYDQLRPWLGNGLIMSTGDVWKVHRRLLTPAFHFDILKQYVSVYNRAA

EHM

(gap) 92% to fgenesh2_pg.scaffold_152000001|Brafl1

MEKLSLYTGKEDSFEMFHQASLCTMEVILLCAFSGGEMSEQM

KNEYVEAVKRIGILQVDRNFNPIYVLFPAIYYLSP

GGREFLRLCDFVHDTGGSIIKRRRQELERDPEILAEKKRLDFIDTLLMARDEDGRGLTDLEIREEVDTFLFAGHDTTAST

LSWALYSLAQHPHHQDKVREEVDQLLAGREEDTIQWEDLHKLPYLTMCLKEAMRLHSPVPFISRTVTEDTVIDGVHIPEG

SYIGIHLYALHHNPDIWGDQHMEFDPSRFHPDRMKDMDAHAFMPFSVGQRNCIGQNFALNEEKVILARLLHKFTFDLDPA

RPVEKDMIVVMKTRDGMWMKVKSTGHTAD*

 

>fgenesh2_pm.scaffold_152000003|Brafl1 36% to CYP4F8

81% to fgenesh2_pg.scaffold_152000001|Brafl1

MRTPVSPVDVAVGLLVPLVGYLLFVVAKFLRTQWRLFRVGLQFPSPPYHWLYGNMHLTDGYLGERYLSMIREVVQKHPHA

HSFWLAGFLAGITVAHPVTIKQLLKTSSNGLIMSTGDVWKVHRRLLTPAFHFDILKQYVSVYNRAAEHMIEKLSEYTGRE

NSFEMFHQASLCTMEVILQCAFSGGEMSEHNPVYVLFPAIYYLSPGGREFLRLCDFVHDTAGSIIKRRRQELERNSEILA

EKKRLDFIDILLMARDEDGRGLTDLEIREEVDTFLFAGHDTTASTLSWALYSLAQHPHHQDKVREEVDQILAGREEDTIQ

WEDLHKLPYLTMCLKEAMRLHSPVPFISRTVTEDTVIDGVHIPEGSYIGIHLYALHHNPDIWGDQHMEFDPSRFHPDRKK

DMDSHAFMPFSAGQRNCIGQNFALNEEKVILARLLQKFTFDLDPARPVEKDMIVVMKTRDGMWMKVKSTGQTAD*

 

$$$$$$$ CYP4F related may be in a cluster on scaffold 141

 

>e_gw.44.127.1|Brafl1 48% to CYP4F12

98% to fgenesh2_pg.scaffold_141000110|Brafl1

93% to e_gw.44.1.1|Brafl1

89% to e_gw.44.121.1|Brafl1

83% to fgenesh2_pg.scaffold_141000106|Brafl1

MRDTLKQFTAPPKHWLFGHLKALPNNEEGFQTRLEWMKTYSAYFWPFWVGPFLVANQCTHPETIRTILGTAEPKGMTYRF

FEPWLGDGLLTSKGSKWHRNRRLLTPAFHFEILKPYVTLFSQSTNVLIDKWSRVAAGSSVELFDHVSLLTLDSMLKCSLG

YRSDCQTDGQSAPYIRAVFELSRLIVERVRFFPYHFDFIYYLTSSGRRFRQQCDIVHGVSEHLIRQRKKALQDGDTKEEK

SKKYLDFLDILLQAKDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRREAEGLLQGRTEMTWE

DMSKLPFITMCIKESLRIRPPVPSVSRRLTKTLTFPDGKYMPEGSLVSARIMSTHHNHLIWPDPEVYDPLRFSPERSKDR

HHHAFVPFSAGPRNCIGQNFAMNEMKVAVALILQRFRLELDETKPSPFFLQQLILRAKDGIWVKLTPNNLKDLDQTNTQ*

 

>fgenesh2_pg.scaffold_141000110|Brafl1 98% to e_gw.44.127.1|Brafl1

MVFSIGDGLLTSKGSKWHRNRRLLTPAFHFEILKPYVTLFSQSTNVLIDKWSRVAAGSSVELFDHVSLLTLDSMLKCSLG

YRSDCQTDGQSAPYIRAVFELSRLIVERVRFFPYHFDFIYYLTSSGRRFRQQCDIVHGVSEHLIRQRKKALQDGDTKEEK

SKKYLDFLDILLQAKDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRREAEGLLQGRTEMTWE

DMSKLPFITMCIKESLRIRPPVPSISRSLTKTLTFPDGKTMPEGSLVSARIMSTHHNHLIWPDPEVYDPLRFSPERSKDR

HHHAFVPFSAGPRNCIGQNFAMNEMKVAVALILQRFCLELDETKPSPFFLQQLILRAKDGIWVKLTPNN*

 

>e_gw.44.1.1|Brafl1 93% to e_gw.44.127.1|Brafl1

MRNTLKQFTTPPKHWLFGHLRAVPPNEQGFQTMLEWMKTYSAYFWPFWVGPFLVANQCTHPETIRTILGTAGKIIIPKSL

TYRFFEPWLGDGLLISEGSKWHRNRRLLTPAFHFEILKPYVTLFSQSTNVLIDKWSRVAAGSSVELFDHVSLLTLDSMLK

CSLGYRSDCQTDGSSAPYIRAVFELSRLIVERVRFFPYHFDFIYYLTSSGRRFRQQCDIVHGVSEHLIRQRKKALQDGDT

KEGKSKKYLDFLDILLQAKDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRREAEGLLQGRTE

MTWEDMSKLPFITMCIKESLRIRPPVPAVSRHLTKTLTFTDGKTIPEGSLITAGIISTHHNYLIWPNPEVYDPLRFSPER

SKDRHHHAFVPFSAGPRNCIGQNFAMNEMKVAVALILQRFHLELDETKPSPFFLQQLILRAKDGIWVKLTPNN*

 

>e_gw.44.121.1|Brafl1 89% to e_gw.44.127.1|Brafl1

MRNSVKQFTAPPKHWLFGHVKVAPMNEQGFQTRLEWMKAYSAHYLPFWIGPFTVFNNCNHPDTIRTILGTAEPKSMTYRF

LGPWLGDGLLTSKGSKWHRNRRLLTPAFHFEILKPYVTLFSESTNVLIDKWSRVAAGSSVELFDHVSLLTLDSMLKCSLG

YRSDCQTDGQSTPYIRAVYELSRLVLERIQFFPYHFDFIYNLSPSGRRFREQCDIVHGISEHLIRQRKKALQDGDAREEQ

RRKYLDFLDILLQAKDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRREAEGLLQGRTEMTWE

DLSKLPFITMCIKESLRIRPPVPNISRSLTKTLTFPDGKTLPEGSLVTGRIIVTHHNHLIWQDPEVYDPLRFSPERSKDR

HHHAFVPFSAGPRNCIGQNFAMNEMKVAVALILQRFRLELDETKPSPFFLQQLILRAKDGIWIKLTPNN*

 

>fgenesh2_pg.scaffold_141000106|Brafl1 83% to e_gw.44.127.1|Brafl1

MTRGPCIHLIRLPHDPTRRSALHAEDRTGMCGPQTSQVLQHLSTYLSPAGTWFHLVRFTCLAVLLVHLSIRILRFVSWQI

KMRNSVKQFTAPPKHWLFGHVKVAPMNEHGFQTRLEWMKAYSAHYLPFWIGPFTVFNNCNHPDTIRTILGTAEPKSMTYR

FLGPWLGDGLLTSKGSKWHRNRRLLTPAFHFEILKPYVTLFSQSTNVLIDKWSRVAAGSSVELFDHVSLLTLDSMLKCSL

GYRSDCQTDGAVYELSRLVLERIQFFPYHFDFIYNLSPSGRRFREQCDIVHGISEHLIRQRKKALQDGDAKEEQRRKYLD

FLDILLQAKVESSH*

 

>fgenesh2_pg.scaffold_141000105|Brafl1 62% to CYP4T

87% to e_gw.44.127.1|Brafl1

MCAQDEDGTGLTDAEIRDEVDTFLFEGHDTTASGISWALYHLAKHPEYQDRCRREAEGLLQGRTEMTWEDLSKLPFITMC

IKESLRIRPPVPNISRSLTKTLTFPDGKTLPEG

TALARISSMNAAHPSGKGWDWITPPNNWRDLDQTYAL*

$$$$$$

 

>fgenesh2_pg.scaffold_110000050|Brafl1 44% to 4F22

MAASADDEQSRDVSEFLRLLSARLPAGVTGTTLVMWTLALVLAVRLAVYVVNFIAWQRSQHNTVSSPF

LQDQLLSHDHNY

HYFTCWQTPIIALTFCSHPETVKLILSNKRDGLLLSDGPKWQRNRRLLTPAFHFDILKHYVKLFSESTAVLLNKWLSRGA

AGASVELFDHIGLMTLDNILKCSLGYNSRCQTDGQSAPYVLAVHDLTKLIEDRPDYLSNHIDFIYYLSADGRRFRRACKI

VHSFSAQVIKERKEELKKKDSSFKSGKCLDLLDILLKAKDEDGTGLSISEIQDEVNTFLFGGHHTTASGISWTLYHLAKH

KDYQDKCRREVEGVLQGRAEMTW

(gap)

NCIGKNFAMNEMKVSVALILQHFQLELDETKSPAVPFDSLTVQAKDGIWVKLHPVKNDT*

>fgenesh2_pm.scaffold_74000030|Brafl1 43% to CYP4F8

MDLKKILADQGYLLEFLLEQTQRFPKCFQQWVGPFRGILVVVHPELAKDVLKTIEPKSRVYEYLRPWLGDGLLLSKGEKW

RRNRRLLTPAFHFEILRPYITVYNQATDVFMEKMSSFAMKNEAVEITEHLSLLTLDIILQCAFSHNIDCQRIGAKHPYVA

AVHAMSQLVILRAMNPWMHVWPMYRLTPQGRKFVEMYNLVHQEANSIIKARREVLNSEIREKMGRESRYLDFLDILLTAR

DPDGEGLTDEEIRAEVDTFLFEGHDTTATGISWSLYCLAKHPEHQDRVREEVDAVMADKDELVWEDICKLKYLAMCLKEA

MRLYPPVPIVSRRITRDFDFQGHRLPAGTNVDLNVWCMHRNPAVWGKDVMDYKPFRFSPENMTKMDPYAFIPFSAGPRNC

IGQNFALNEEKVVISRILHRFKVELVPDHPVVPSLQIVSRAANGIKVKFIPRS*

>e_gw.501.36.1|Brafl1 43% to CYP4F11

79% to fgenesh2_pm.scaffold_74000030|Brafl1

EHVLEHMTEMVQRFPRCFQQWIGPFRGGLMVVHPELAKEVLKTIEPKSRSYEYLRPWLGDGLLLSKDEKWRRNRRLLTPA

FHFEILRPYVRIYNQATDVFMEKMSRSFAQKGKAVEITKHVSLLTLDIILQCAFSHNIDCQRHPYVGAVYAMTQLIMSRT

RNPWMMHLWPMYRLTSEGREFVKLYNLVHQQADDIIKARRQVLVSREKEGKEKMGRGSRYLDFLDILLTARDPDGEGLAD

EEIRAEVDTFLFEGHDTTASGISWSLYCLAKHPGHQDRVREEVDMVLAGKDDEELTWQDISKLKYLAMCVKEAMRLYPPV

PIVSRRITRDFVFMGHPLPTGATININAWCVHHNPTVWGEDFMNYKPERFSSENMKNMDPYAFIPFSAGPRNCIGQNFAM

NEEKVVIARILHRYVNIY*

>gw.522.22.1|Brafl1

77% to fgenesh2_pm.scaffold_74000030|Brafl1

LEQMIELVQRYPRCYQQWIGPFRGCLMVVHPELAKEVLKTIEPKSRVYEYLRPWLGDGLLLSKDEKWRRNRRLLTPAFHF

EILRPYVRIYNRATDVFLEKMSSFAEKGEAAEITKHLSLLTLDIILQCAFSHNIDCQRHPYVGAVYALCQLIMSRVGTPW

MHLWPMYRLTAEGRKFVRLYNLVHQQADDIIKERREVLVSEGREKMGRGSRYLDFLDILLTARDPDGEGLTDDEIRAEVD

TFLFEGHDTTASGISWSLYCLAKHPGHQDRVREEEN

VRKLLRAQAQAQVVAFLVTFLKLQ

DISKLKYLAMCMKEAMRLYP

PVPIVSRRTTRDFDLMGHRLPAGATLNINTWCLHHNSTVWGEDFMYKPDRFSSENMKKMDAYAFIPFSAGPRNCIGQNFA

LNEEKVVIARILHRY

>fgenesh2_pg.scaffold_44000110|Brafl1

80% to fgenesh2_pm.scaffold_74000030|Brafl1

MRMDLKLLLLVVLAVAIISDVAQGQGRFGIRDGGREPDDEAVGAGLRAEDHVAGARKPRDLGDVLAAVYLWKETRFQEKA

LAPFPCPERHWLQGTMDLKRIKKHPEHVLEHMTEMVQRFPRCFQQWIGPFRGGLMVVHPELAKEVLKTIEPKSRSYEYLR

PWLGDGLLLSKDEKWRRNRRLLTPAFHFEILRPYVRIYNQATDVFMEK

(gap)

EGKEKMGRGSRYLDFLDILLTARDPDGEGLTD

EEIRAEVDTFLFEGHDTTASGISWSLYCLAKHPGHQDRVREEVDSVLAGKDDEELTWQDISKLKYLAMCVKEAMRLYPPV

PIVSRRITRDFVFMGHPLPTGATININAWCVHHNPTVWGEDFMDYKPERFSSENMKNMDPYAFIPFSAGPRNCIGQNFAL

NEEKVVIARILHRFKVELVTDHYVAPVIELVTRAVNGIKVKFIPRD*

 

>e_gw.5.20.1|Brafl1 44% to CYP4F12

GNGLLLSDGDVWKVHRRLLTPTFHFDALKQFTHVYNKAAEQMIEKLMEFAESSESFEMFQHASLCTMEVILQCAFSAGGI

HDLSVSPPCLVNICCNNKKTVFAFFYSNPIYSFFTSIYNLSAGGREFKRLCDFVHDTADSIIKTRRQQLDSHNEVVEPKK

RLDFIDILLTARDEDGRGLTDVEIRQEVDTFLFAGHDTTASALSWTLYSLAQHPHHQDKVREEVYHLLSGRDDDTIQWND

LSKLPYLTMCLKEAMRLHSPVPHISRATKEKCVIEGVNIPKDTYMGISIYGLHHNPTVW