Candida dublinensis P450s

 

D. Nelson

 

August 9, 2009

 

10 sequences

 

>CYP51F1 Candida dublinensis

93% to CYP51F1  Candida albicans, cdub_2-g61.1, GenEMBL AJ012573

MAIVETAIDGINYFLSLSVTQQITILLGVPFVYNLIWQYLYSLRKDRAPLVFYWIPWFGSAASFGQKPYEFFESCRQKHG

DIFSFMLLGKIMTVYLGPKGHEFIFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTESFKRYVP

KIREEILDYFVNDESFKLKEKNHGVANIMKTQPEITIFTASRSLFGDDVRKLFDRSFAQLYSDLDKGFTPINFVFPNLPL

PHYWRRDAAQKKISATYMKEIKLRRERGDIDPSRDLIDSLLTHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL

LHLGEKPHLQDAIYQEVVELLKEKGGDLNDLTYEDLQKLPSVTNTIKETLRMHMPLHSIFRKVKNPLRIPETNYVVPRGH

YVLVSPGYAHTSERYFDNPNNFDPTRWDTAAAKANSVSFNSSDEVDYGFGKISKGVSSPYLPFGGGRHRCIGEQFAYVQL

GTILTTFVYNLRWTVEGNRVPDPDYSSMVVLPTEPARIIWEKRETCMF

 

>CYP52A25 Candida dublinensis

79% to CYP52A3   Candida maltosa

cdub_593-g99.1

MSSATTSSNIIDSVLPYLTKWYTILIGAGLIFILSTNLKNAYYSYKLGCKNPVYLKRAGWTGIPALIDAIKAKNSGKLAE

FGDDTFEELNTKTFYLNVAGVLKIIFTIDPENIKAVLATQFNDFSLGTRHAHFYPLLGDGIFTLDGEGWKHSRAMLRPQF

AREQIAHVKSLEPHIQILAKQIKLNKGETFDLQELFFRFTVDTATEFLFGESVHSLYDDKLGIPPPNDIPGRDNFATAFN

ISQHYLATRSYSQTFYWLTNNKEFRDCNAKVHYLAKYFVDKALNSTEEEIEEKSQGGYVFLYELVKQTKNPKVLQDQLLN

IMVAGRDTTAGLLSFAMFELARNPKVWNKLREEIETNFGVGEESRVEDITFENLKKCEYLKAILNETLRLYPSVPINFRT

STKDTTLPTGGGRDGTSPIFVPKGSTVAYTVYKTHRLEEYYGKDSYEFRPERWFEPLTKKLGWAYLPFNGGPRICLGQQF

ALTEASYVITRLAQLFPVLETREKQYPPNKCIHLTMNHDEGVFVSMN

 

>CYP52A26 Candida dublinensis

89% to CYP52A21   Candida albicans

cdub_14-g136.1

MLEEISFESWYIYLFICGVLYFGSKYFYTQYLNNKFGAKLPGSFRSDGLFGFKNGFEMLKAKKVGRQVDLVHSRFNDLSK

THVNDTFKEYNFGIPVIVTKDPENIKALLATQFNDFSLGRRSDFFYPLLGKGIFTLDGEGWKHSRAMLRPQFAREQIAHV

KALEPHFQLLKKHITKNKGKGFDIQELFFRFTVDSATEFLFGESVSSLKDESIGYNQDEFDFDGRKDFPEAFNKAQIYLA

TRAILKDLYWLVNPKDFQNCNAIVHKFSDYYVNKALNATPEELEKNSGYVFLYELVKQTRDPQVLRDQALNILLAGRDTT

AGLLSFAMFELARNPQIWQKLREEVIEKYADEVTEIAFETLKQCEYLKAVINETLRLYPSVPRNGRFANKNTTLPRGGGP

DGMSPILIKQGQGVLYSIYSTQRDTKFYGKDADVFRPERWFEPETRKLGWAFLPFNGGPRICLGQQFALTEASYVLVRLA

QSYENLQLTENIEYPPPKLTHLTMCMFDGVPIKIA

 

>CYP52A27 Candida dublinensis

94% to CYP52A23   Candida albicans

cdub_14-g720.1

MTVSTLEIQDIIQQYITKWYVIIPTLFVVYQVVDFLYVRSLRSRFGAKAPTNNESDGYWGFHLPFLLVSKKAEGTIIDFA

GERFKNITHPEVPTFQFPIFTVKVISTVDPENIKAVLATQFNDFSLGTRHNQFAPLLGDGIFTLDGAGWKHSRSMLRPQF

AREQVAHVKALEPHMQVFFKHVRKSGGRTFDIQELFFRLTVDSATEFLFGESVESLRDESIGMALEAVDFDGKKEFAQAF

NFSQNYLASRAVMQQMYWLLNSSEFQSCNTKVHKFAEYYVNKALELSPESLEKQQGYVFLYELVKQTRDTKVLRDQLLNI

LVAGRDTTAGLLSFVFFELARNPRVFAKLREEIEQKFGVGEDSRVEEISFESLKLCEYLKAVLNECLRLYPSVPQNFRVA

TKNTTLPRGGGPDGLSPILVRQGQTVMYSVYVTHRDTKVYGKDANEFRPERWFEPETRKLGWSFVPFNGGPRICLGQQFA

LTEASYVTVRLLQEFGHLTMDPNTQYPPKKMSHLTMSLFDGTNVEMY

 

>CYP52A28 Candida dublinensis

93% to CYP52A22   Candida albicans

cdub_14-g719.1

MSPSLVHQILAIAHPYVEYLQANFTKWYILVPGILIALNVLTFLYTKYLEYKFNAKPVTNFIQDYTFGVLTPLILIYYKS

QGTVMEFANNLWGNRFFIKNADVGTGELRIFGMHLIETKDPENIKAILATQFNDFSLGTRHGFLYSLLGDGIFTLDGAGW

KHSRSMLRPQFAREQVSHVKILEPHMQVFFKHVRKNKGKAFDIQELFFRLTVDSSTEFLFGSSVESLRDETIGMSPSVKN

LAGRDEFAEAFNYSQTINAYRFLLQQFYWLCNGSKFRKSIATVHKFSDFYVQRALSLSKAELDDQKGYVFLYELAKQTRD

PKVLRDQLLNILVAGRDTTAGLLSFVFFELARNPTVYAKLKEEIYNKFGSGEDARIDEITFESLKQCEYLKAVINESLRL

YPSVPHNFRTATRNTTLPRGGGPDGMSPIVVKKGQSVMYTVLATHRDTKTYGADANDFRPERWFEPETRKLGWAYVPFNG

GPRICLGQQFALTEASYVTVRLLQEFGHLTMDPETCYPPKLMNSLTLSLLEGANVEMY

 

>CYP52C4 Candida dublinensis

94% to CYP52C3   Candida albicans (ortholog)

cdub_588-g100.1

MLILLPVAVLAAIIYYIAEYWRKESIKRKYDCQPVKQAPLVTWYDIFGIKALIDNSNLTKSGYFYQDIQRKLDSLDTTTL

KTTALGKNQIITIEPENFRTMCSSADLNNWTIGTRPIALKPLLGNGIFSSEGESWKHSRIMLRPIFAKEHIKQITAMESY

IQLLIKVIKIQQQQQEEFDLQHLFHCFTIDYATDFLFGESCDCLKLILGETSISTMSEKEKSKFAPNFDIMQYHMTKRLV

FGYFSFLINPPEFQNAVKHLHEFVFHFVDRAINFTDEELNDPSKNYVFLYQLAKQTKDRKVILDELLSVLLAGRNTTASL

LSFMFFELAQNKPVWNKLKQEINQHFPDVESITFDTINNCEYLRWCIHESLRINPPVPINTRTANKDTVLPKGGGKGNNY

PIFVRKGEQVIFPLFSSNRQERFFGPEPEKYIPERWANLPRNGGIAFGPFGTGPRLCLGQQLALVEASYVTIRLLQTFSE

LDSNHTECRRLVGATMRLMDGCQVTLK

 

>CYP56E3 Candida dublinensis

96% CYP56E2   Candida albicans (ortholog)

cdub_14-g334.1

MLQLLKYIFIGGFTYLLYLILEIVFPPFNFPRNIPTIPFYVSFLGACTSLDQEDIYKLYLREKLEKYGAVKMYFASRWNI

LITKPDFLLEMFKNEDVFAKSGNHVKIPNSVLATYTGDNIISAHGELWKLYRDVVAQSIQFPDLKPIFKNTHKLLRFINN

EMGSANQTTISVTDILQKYSLANVCESVLGVNFNVLDDKQSLMHEKIKYVKLQIFNPIFLNFPYFDNFPIPSRLKARREV

IGFRKWYGQSLVEKYNLQLPNSAATKLVDSLIKEKLTEKQFLDNAIILMIAGHENPLLLMLSLLYVVSKYPQVQELIRNE

TEPTKPYFHSVIYETLRMYPPLGLIINRCTTRITKLGNIVIPKNVYCGYNNFGTGRDRNVWGSDADTFKPERWGVEIDEI

NKKFTLAKRSAELPAFHGRKRACLGEKYALFEVKQFLLAILGDYKVSLDPTWKEQLTAAGPISPLQLKIKFEKLTVS

 

>CYP61A1 Candida dublinensis

96% to CYP61A2   C.albicans

cdub_7-g12.1

MNSTEVDNLPLHEQLTSFVELAIAKATGSPITTLFTIIFLILLYDQLSYQINKGSIAGPRFKFYPIIGPFLESLDPKFEE

YKAKWDSGELSCVSIFHKFVVIASSRDLARKILSSPKYVKPCVVDVAVKILRPSNWVFLDGKQHTDYRRSLNGLFSSKAL

EIYIPVQEKYMDIYLEKFCNYDGPREFFPEFRELLCALSLRTFCGDYITDDQIAVVADNYYRVTAALELVNFPIIIPYTK

TWYGKKIADDSMKVFENCAAMAKKHINENNGTPTCVMDEWIHLMKEAREKHSEDPDSKLLVREFSNREISEVIFTFLFAS

QDASSSLACWLFQIVADRPDVVAKIREEQLRVRNNNPDLRLSLDLINQMTYTNNVVKETLRYRPPVLMVPYVVKKSFPVT

ESYTAPKGAMIIPTLYPALHDPEVYDEPDSFIPERWENASGDMYKRNWLVFGTGPHVCLGKNYVLMLFTGMLGKFVMNSD

MIHHKTDLSEEIKVFATIFPKDDLILEWKKRDPLKSL

 

>CYP501A3   Candida dublinensis

89% to CYP501A1v1     Candida albicans

cdub_11-g248.1

VSNNIKSQFLNYIINNNSNRSNHGRGQ this seq may bw an intron (too long) remove it

MLLSIRWDEALLILLNYLNDYPVTITCFLILLTIVFGIVIDYTITPKEIANIFSIPGELPFIGHLHLILENPALIYLTWS

KLYNQSVFQIRIGNKRVVVVNSFDDVVGLWINHSCQNNSRPLSYTFHDLVSAIQGFTIGSTPASSTFQKKKKTISQYLNK

RQIELKLDIINRQINIMIGELWKRDIEFEDINLLPYFQKFVLQTAIFIGYGIELDCYKEHNQFCQEIIDIENKIIRLRSP

ISNLQDSIPLLRIMPRWFNNSEIARICGEKRNIYMNKLYQQLQQGLADDLPQYKNSILGDLITKTKNRNDNGESGGMNCI

SRNNCLNEQEIQSICLTLISAGLDNTPLSLNYLFGILSHPKLGERLQTRAIKDILENSGGNAILAWEKVLLLQALVTTNQ

KNLMNCQYIEALIMETLRHFTVLPLSLPRLTSKEIRYKNFVIPKETHLFMNAYSANHDCQIFVNPYKFDPDRWLDP

FKSHHNHQHFAFGAGSRMCSGYNLVIKQMYVMVIKMLLIFEIHPPTNTKKLMELNPF

INNLNPKGTSFEPKTNQINLKFRKLPNYKSLHELILQQD

 

>CYP5217A1   Candida dublinensis

93% to CYP5217A1   Candida albicans (ortholog)

cdub_11-g19.1

MLKEIAYTLYSYMVAHPVQTQVIVLIAVLVYYLVVFPVTSPLWKIPGPYIHRISYIPCYNAQRNGTWIARVHELHKKYGN

VIILSPNEVSVNGDPKFINDIYVKNFPKSKFYENFRNHGFKDNIFASLENDRHRKYKKLINNLYNKTAIFSKENHTRSVL

LETADKLVETVGKESPSIEVFTLFGALAMDVVSRFELGRSNGTNLLDSSSDRRIIVSHREVSSMGFWTTLMPTFLWDYAA

TKSILQAADDICNFQLNLYKFAEKNLTSNGKNLTTFETLKKNGFEGEYAYSFLTDNLFAGHETTAVQLTYLCYELSRPAN

YKMQQKLREELHEAFPDGKIDLETVDSLPYLNALFAENGRVHTSIPGAEPRVVDKPYLVDNMVIPQGTIISCLPYSFHRT

ESVFPEPDKFIPERWIINNEEDKWRVKRQEKYMMPFGKGVRMCLGMNLAMIEMKLAIAKLYWHYGSAIDETWCKVLNDAK

PIEMGGGGDGSTDQDKMRMYDWYTTRPLYDECWLKWEKL