Debaryomyces hansenii P450s

 

D. Nelson

 

August 9, 2009

 

9 sequences

 

>CYP51F1  Debaryomyces hansenii

75% to CYP51F1   Candida guilliermondii

CAG88416.1

MALADYSIALYNYFTSLAIVQQASIIILFPFIYNLLWQFFYSFRKDRVPLVFHWMPWVGSAVVYGMQPYEFFENCRTKYG

DVFAFVLLGKVMTVYLGPKGHEFVLNSKLQDVSAEEAYTHLTTPVFGKGVIYDCSNSRLMEQKKFAKYALTKDSFRKYVP

KIKEEVLSYFTDSENFNMKGKSSGVVNVMESQPEITIFTASRSLMGDEMRKKFDASFAQLYTDLDKGFTPINFVFPHLPL

PQYRKRDAAQQKISSTYMSLISKRRDTGDIDPSRDLIDSLMTHSTYKDGVRMTDQEIANLLIGVLMGGQHTSASTSAWFL

LHLAENPSLQDEVYEEILSVLKQKNGSFNDLDYDDLQNMPLLNNIIKETLRMHMPLHSIFRKVKNPLLVPNTQYVVPKGH

HVLVSPGYAMTNEKWFPEAAKFKPHRWDETAKATGNEDTVDYGFGAITKGVASPYLPFGGGRHRCIGEQFAYVQLGTILS

TYVYNMKWSLKDGKMPEIDYASMVTLPMEPADICWEKRENCVI

 

>CYP52A43 Debaryomyces hansenii

54% to CYP52A3   Candida maltosa

CAG85755.1

MNWYIIIFIAYFVRRLIILCKNYWLARQWGCEPMQEFGGRFGIISLINVIKARREGFLVDYQKQTYIETDTDTIKSRLFH

KQLIHTKNAENVKAVVATQYDDFSIGKRHKFFKPLLGNGIFASEGERWQHSRTMLRPQFARERVAHVQALEPHLQVFAKH

VRKSEGGVFNIQILFHKLTIDAATEFLFGESVDSLRDASIGYESLPTDIDGKAGFDDAFNISQNYMMLRALAQDLYFLFD

SKEFREANRKIHKFTGHYVHKALETTQEELDAKSRDGYIFLYELVKQTRDPIILQDELLSIMLAGRNTTASLLSFLFFEL

ARNPEIWSKLKREVYEHFGNGDDVKLEKITFESMKKCTYLKWVINETLRMYPSVPQNFRVAKKDTTLPRGGGKDQQSPIF

VPKGQFVLYTTYSMHRLEAYYGKDADVYRPERWENLRNIGWAYMPFSSGPRVCLGQQFALTEASYITIRLAQMFPNLESH

DSKYPPPKLTNSTMRHLDGVFISLH

 

>CYP52A44 Debaryomyces hansenii

63% to CYP52A25   Candida dublinensis

CAG85832.1

MSTDKLKSYVEEISPYLTQWYVIALGGILVWYIGTSIKAYQFKQKYGCKEPPLVPGGFLSIKLLLDLLKTKSEGTMLEYA

EHFFSLVKSQTFKLKLATVPIIFTQDPENIKAVLATQFNDFALGTRHAHFKPLLGDGIFTLDGDGWKNSRLLLRPQFARE

QVAHVQTLEPHLQTLAEHISNKKGETFDIQELFFRLTVDAATEFLFGESVYSLRDGTVKDVAPLDFDGKSSFADSFNLSQ

SYLASRAYSQMFYFLINNKEFRNSNTKVHKFCKHYVEQALATSQDELDKKSKDGYIFLYELVKQTRNPKILQDQLLNILL

AGRDTTAGLLSFTFFELARNPDVFEKLKNEIYTHFGDGANPRIETITFESLKRCEYLKFVLNEVLRLYPSVPINFRVSTK

DTTIPRGGGPDKQDPVYVAKGTTVAYSVYTTHRLEQYYGKDSREFRPERWAENKKVGWAYVPFNGGPRICLGQQFALTEA

SYVVVRLIQMFPNLVSRDDRPYPPRKNVQLTMCHQDGVFISLNK

 

>CYP52A45 Debaryomyces hansenii

62% to CYP52A14   Candida tropicalis

CAG88380.1

MSSDTFHEFGVLFDRIQPYLTSLWAICIGAYILFSISTRINDRILMKKLGAKPMQMNAPNSFWGIPLMFRLLKAKREGTM

VDVTKERYKELGVDTFNVNIAGTHAVVTRDPENIKAILATQFNDFALGKRHTHFKPLLGDGIFTLDGAGWKHSRTMLRPQ

FAREKVAHVKALEPHLQTLAKHIINSKGERFDIQPLFFRLTIDSATEFLFGESVENLHDESVGLTRDPVDFDGKSGFADA

FNTSQTWLASRAVTQNLYFLVDGRSFRSSNAKVHKFADYYVRKALEASSEDLEKASRDGYIFLYELVKQTRDPVILRDQL

LNILLAGRDTTAGLLSFTFFELARNQDVYDKLKEEIYEKFGEGEDSRVDEITFESLKKCEFLKCVLNEILRMYPSVPQNF

RFAIRNTTLPKGGGPDGKSPIFVSKGKNLFYSMYSAHRNPKYYGKDAEEFRPSRWLEPEIRKVGWAFLPFNGGPRICLGQ

QFALTGASYIVVRLIQMFPNLSSFCEEYPPRKNTQLTMSHQNGVYIGMF

 

>CYP52A46 Debaryomyces hansenii

63% to CYP52A14   Candida tropicalis

CAG88381.1

MSSSAHELFRSIEPYLTNWWIICIGTYVLFSILTWINERILMKKLGAKPIQFIAPDPFWGIPLMFRLLRKKKDGTMVDMT

KERFEEFGIETFSFRVGGTPVITTKDPENIKAMLATQFNDFALGKRHTYFKPLLGDGIFTLDGAGWKHSRAMLRPQFSRE

QVAHVRALEPHLQTLAKHIINSKGERFDIQPLFFRLTIDSATEFLFGESVENLHDESVGLTRDPVDFDGKSGFADAFNTS

QAWLASRAVSKNLSLFVDGKEFRNSNAKVHKFADYYVRKALEASPEDLEKASRDGYIFLYELVKQTRDPVILRDQLLNIL

LAGRDTTAGLLSFTFFELARNQDVYDKLKEEIYEKFGEGEDSRVNEITFESLKKCEFLKCVLNEILRLYPSVPLNTRCAT

KNTTLPRGGGPDGQSSIFIPKGKSVLYSVYATHRNPKYYGKGAEEFRPSRWLEPEIRKVGWAFLPFNGGPRICLGQQFAL

TEASYIIVRLIQMFPNLNSFCEKYPPRKSSHLTMCHQDGVSIGMF

 

>CYP52A47 Debaryomyces hansenii

65% to CYP52A14   Candida tropicalis

CAG88382.1

MSSNFHEVVESIEPYVTNWWFICIGAYVLFSILTWINKRILMKRLSAKPMQVTARDAFVGIPLVFNLLKAKREGTMVDMT

KERYEEFGVDTFDFRIAGTHAIATRDPENIKAVLATQFNDFVLGKRHAHFKPLLGDGIFTLDGAGWKHSRAMLRPQFARE

QVAHVKALEPHLQTLAKHIINSKGERFDIQPLFFRLTIDSATEFLFGESVESLHDESVGLTRDPVDFDGKSGFADAFNNS

QAWLASRAVSQNFYFLLNGKDFKDSNANVHKFADYYVNKALETSPEDLEKASRDGYIFLYELVKQTRDPVILRDQLLNIL

LAGRDTTAGLLSFTFFELARNQDVYDKLKEEIYKKFGEGEDSRVDEITFESLKKCEFLKCVLNEILRMYPSVPQNFRFSI

KNTTLPRGGGPDGKSPILIPKGQNLLYSVYATHRNPKFYGKDADEFRPSRWLEPEIRKVGWAFLPFNGGPRICLGQQFAL

TEASYIIVRLIQMFPNLGSFCEEYPPRKSSHLTMCHQDGVFIGMS

 

>CYP61A1 Debaryomyces hansenii

80% to CYP61A1   Candida lusitaniae

CAG86871.1

MSTNSTSEIVDNLSGSFGDTSFFIKTANDLYMNMSWLQLIITTIVLGLSYDQIMYQIRKGSIVGPRLKVWPIIGPFLESL

DPKFEEYKAKWDSGPLSCVSIFHKFVVIASSRDLARKILGSPKYVKPCVVDVAIKILRPTNWVFLDGKAHSDYRKSLNGL

FSQKALELYIPVQEKYMDLYLEKFVTLDGPTEFFPQFRELLCALSLRTFCGDYITEEQISLITDNYFRITAALELVNFPI

IIPYTKTWYGKKIADETMKIFESCAGMSKKHINEDNGKPGCVMDEWIYLMKDAREKHSDDPESKLLIREFSNREISEVIF

TFLFASQDASSSLACWLFQVVADRPDIVAKIREEQLRVRDQDPSKPLNLELINEMTYTNNVVKESLRYRPPVLMVPYVVK

QSFPVTDTYTAPKGSMIIPTLYPALHDPEVYEDPDSFIPERWENATGDMNKRNWLVFGTGPHICLGKTYVLMLFTSMLGK

FVMNSDIIHYPTPLSEEIKVFATIFPKDDLILEWKRRNPLQV

 

>CYP501D1 Debaryomyces hansenii

45% to CYP501A2     Candida tropicalis

CAG86740.1

MVFATMGSAIFDFIRLLITFWNYKILNLLNIIFAIFLLSIFMDLVLGIGVPLKIKGIFAIPGYPIVGNLFQVLNNPALVY

IQWANKYNASIFQIRLGFKRIIVVNSFEDVNILWTKHSCSNNSRPVQYIFHGIVSATQGFTVGSTPSGPSYKRKKKVISQ

SLNQKSVNNLSSVIDNETKFTIKNIIQNNRELFGPPSCNNYRYTRTIISDIDLLCYAQLYSLRSAIFLTYGLHLDVYDSE

ADLAKEIIEVESNIMKFRAPVSNLQDYIPILRYLPFGKSMQAQHYRNRRDAYMNKLFQQLQEKILEGDVDSSNSLVGVAI

KNMELTLKLTSAELQSICLTMVSAGLDNTSLNFNHLMGQLSQPTTGYIYQRKAFEEMMSRNKNNICTAWDNAAIVMDCSY

VIALIKETLRYFTVLPLGLPRITTKDITYKDAIIPKNSILFMNSYAANHDPNIYKDPMRFIPERWLDLITGLVLSKYEIS

HFSFGAGSRMCSGNHLAFKELYTLTCRMILTFQIRRPTSNKFLMELDPFKNNSNPNAISFEPKLFKVRLEPRIHNRSDDL

YNKILRS

 

>CYP5217A5  Debaryomyces hansenii

51% to CYP5217A1 Candida dublinensis

CAG85742.1

MLREIINKTIYTSIEYHLQIVLGVLFLSVIYFLMVRPFFASPLKNIPGPYWNRVSVFPSLNSQRTHKWIETVYNLHSKYG

TVVVLSPYEISVNGSSQYIKDIYVKNFCKGKFYDNFRNHGHDNPFSELKNDVHLKYKKILMNTYNKTSILSPQNPTRSHL

VSTVLKVLGRVRKEQELNKYRAIDVYSLFSCLAMDVILAFELGKDSGTNLLEHQESEEVVHWYRKKDSMGFWTTLMPRFW

NLAATKEIKQAVNSIEQWHMSLYSHAEKNMNEEKQSYCPSLKVLQLNGFHDKNAYSFITDNIFAGHRTTAIQLTYLCYEI

SRPVNRKWQDILKRELVEHFDEPLNNESIIQDFEIVDKLPVLNALLQENLRVHSSIPGAQPRVVDRKYTVEVQKVDKILK

VLIPEGTIISCLPYAMHRQEEIFPSPDNFKPERWLRYNEENDADFKARISNQQRFMMPFGKGIRLCLGMNLALLEIKFTL

ANLYWHSRSEISDKWCKIENTLGGCPIKLGQISQGMNCTDQEKMVMVDSYTTRPLNDECWLSFYFRNN