Malassezia globosa P450s

 

D. Nelson

 

August 9, 2009

 

6 sequences

 

>CYP51F1 Malassezia globosa

67% to CYP51F1   Ustilago maydis, MGL_2415

MLQEIGAWPVWQQALTFLVGGLALIVGINVLVQVLVPRNKSLPPMVFHWVPVVGSAITYGMDPYRFFFNCREKYGDVFTF

KLFGRNVTVALGPKGSNLVFNGRLTQVSAEEAYTSLTTPVFGKGVVYDVPNAVLMEQKRFVKSGLSMENFRMYVTQIESE

VKDFINNDAAFLPLQKGATSVTVDIFNVFSEITILTASRTLQGKEVRESLDKTFAKLYHDLDSGFTPINFVIPNLPLPNN

FRRDRAQRLMSDFYLGIIKKRREGNTEGTEHDMISALMEQSYKNGRNINDREIAHMMIALLMAGQHTSSATGSWAMLRLA

SRPEIIEELYEEQKRVYSDGTGGFAPLDYDIQKSSVPVLDAVIRETLRLHPPIHSIMRKVKSDMVVPPTLAAPISSKGSR

DETYVIPKGHYVIAAPGVSQVDPKIWEDASRFDPHRWLGDKANVMNQTDDAQEDFGWGMVSTGANSPYLPFGAGRHRCIG

EQFAYLQLGTIISTFVRAFDWRLETKLPAPDYTSMVVLPTQPANLVFTPRKNKA

 

>CYP61A1 Malassezia globosa

74% to CYP61A1   Ustilago maydis, MGL_0310

MSHGQSQQVWDTAMTGNETIPQHTLNTATAQEGFTAVQVAFAVLTVIVSLLALEQMVYRMKKGGLPGSKWTIPIIGKFKD

SLNPTLEKYQESWNSGALSVASVFNIFIVIASSTDYTRKILNSPTYAEPCLVASAKKVLCHDNWVFLNGKTHVDYRKGLN

TLFTSRALSIYLNIQENIYKKHFAKWVALGSKDAEAFMLPLRNLNLETSLRVFCGNYISDEGAQQISDEYWLITMALELV

NFPFAFPGTKVYRAIQARKNAMKWFEHTAAESKKRMALGEEVTCLTDAWVKAMLDAREDRQNDDLGAEQRRILVRDFSDR

EIGMVLLSFLFASQDAMSSGLTYLFQHLADHPDVLRKVREEQYAIRNNDIDAPLTIDMIEKMTYTRAVVKESLRLKPPVI

MVPYMARQPFPISETYTAPKGSMVIPSFWNSLHDPTAYPSPDEFRPERWLEGAESPAAKHPKNYLVFGSGPHNCIGKEYA

MQHLIAVMGDASVLLNWEHKRTELSEKVMVIATIYPKDGAYLKFTQRPAPPMDAPAAVAAAM

 

>CYP5218A1 Malassezia globosa

37% to CYP5031A1, MGL_3996

MAASAFISGADVLYLAAGLAGLLVAVPLLFILNQLVQALYRMTIGELINPWKHIPKVKTTDPLSLIFGDFRAIKAADPAQ

QHVIWMNKLGQVYRYRHMFYVQRVLLADPKALIHVLSPAKAYQYPKPEYTSSFLAAVLGDGLVSIEGEKHARQRKIIAPA

FAPSVVKDYQPTIHRHAKLLVEKLRLIVQQEIDRHSGKIPADTHITGQSESDRSVVLKNPGSEAVIDVLFWLSRTTLDII

GEIGFDADFRSLERGNRDPLANSMATLMEAVLNIDLGLAIFLILSEKPGLQWLRKIPTKRTTTIRDAKKTVEKHAEEIVE

RMRNEILSESQGLSKENFDDGSATRSKSLISRMIRANMASDLKPSERMSNAELMGQMTTLIIAGHETTATQNSWALWLLA

MHPEAQDRLRKELQEAVAKERAEMDNLSEEERAIYDTQPVRDINSLPYLDNVVKESVRMLPSIPSTVRVALKDDVVPLSR

GYKRADGKGTYNSIMIPKGHELFIPLNVIQLSKELWGEDAQDFNPSRWDNLPSSVINAKMPPGHLFAFLSGPRSCVGKQT

AILETQVILAHMILNFRFDVVPGWDLVQRQQIVRRAFVEGQWKEGIRMPLIMTPLN

 

>CYP5219A1 Malassezia globosa

29% to CYP5218A1 Malassezia globosa,

MGL_1059

MFGEPRLMLTDPVGLDHVLRKRAYAFPKIRLAQRLIGGVMGNGLLVAEGEVHRRQRRAIQPGFHSRAIKRLAPVFQQHAF

NLLAYLRTQTREHDSQLIDVYTPLSAAALDALGDGALGASFGALASLIVHPSGIVHAAHPLTAALDRTLRIASHPSKYAL

LMDTATLYFPILEHIPIGLSSHAFRREARVLFDLAGSIVDDAQARIRCETHDTSPDILASLLRANANAKRARSGEKKHSV

LDHAILTDAELHAQVSTFIFAGHETTATQMAWLLLFLAKDQRRQQTLREAIGAKRAALGLMPHARAEPTEACERALSAEE

LEDIPYLDWCVRECLRLQAAIHTTSRVATDTDWIPLSSGRSIQVHRGMIVLIPLTSIMTSEHHWGADPEEFRPERWAEPT

LKGPRAFPAHNGLSFLMGPRACIGSAFALLEMKVFIATVLSELYFEWDGRPIVPKLWVVARPFDASCQQDACILKIRRIS

S

 

>CYP5220A1 Malassezia globosa

39% to CYP5046A2   Phaeosphaeria nodorum,

38% to CYP530A3   Aspergillus nidulans

MGL_4151 identical sequences are on the same contig 9kb apart

25295 MSMVVLQSENTRWAILNWILLTVPLILGFVLMSRRTNRVKHASLPPGPLKFPLIGNF

LQINSTHPVVQFKRWAEKFGPIVHVRLFSHDIIVLNTDLVAKDLLDNRGSIYSSR

NPPYFAYDLMSKKKRMVFHRYGEDWRKARKIMHQLLAPNATAMSGMVQELESRQMLHELL

ESQNSETENVHFFRYFQRYTSSSIMTLCYGHRFFSPQDPCIEGIFEAMDILSRKSLPGAY

LVDAVPFLRRLPVALQPWIREAENLHQKEWELWGSFVDRCKREIEIGEGRDCFIKELLCK

GAQLGSEEERTKEQLSDMDIGYAACALLEAGSDT (0)

TASTIASCCLAMLL

NPAIQEKAHAEIDTVVGPNRLPGYEDEVHLPLVRAIIKETLRWRPPTVMGVPHAVTVDDE

YYGYKIPKGSTVIGNSTCSPKILDVLIWPVFAMSHDPKRYPNPELFDPEARFYKSHPGSA

AEYATKRNSLERDHFAYGHGRRICAG (1)

IHMAEKSLFQGVARILWGFNIMHAVDEVTGKPIEVKASPHEQAYTDG

FVSFPKNFSARFHVRSSDHESTIRRHYASAQDAWEQQGLEVG* 23496

 

>CYP5220A2 Malassezia globosa

39% to CYP5046A2   Phaeosphaeria nodorum,

38% to CYP530A3   Aspergillus nidulans

MGL_4157  identical sequences are on the same contig 9kb apart

36424  MSMVVLQSENTRWAILNWILLTVPLILGFVLMSRRTNRVKHASLPPGPLKFPLIGNF

LQINSTHPVVQFKRWAEKFGPIVHVRLFSHDIIVLNTDLVAKDLLDNRGSIYSSR

NPPYFAYDLMSKKKRMVFHRYGEDWRKARKIMHQLLAPNATAMSGMVQELESRQMLHELL

ESQNSETENVHFFRYFQRYTSSSIMTLCYGHRFFSPQDPCIEGIFEAMDILSRKSLPGAY

LVDAVPFLRRLPVALQPWIREAENLHQKEWELWGSFVDRCKREIEIGEGRDCFIKELLCK

GAQLGSEEERTKEQLSDMDIGYAACALLEAGSDT (0)

TASTIASCCLAMLL

NPAIQEKAHAEIDTVVGPNRLPGYEDEVHLPLVRAIIKETLRWRPPTVMGVPHAVTVDDE

YYGYKIPKGSTVIGNSTCSPKILDVLIWPVFAMSHDPKRYPNPELFDPEARFYKSHPGSA

AEYATKRNSLERDHFAYGHGRRICAG (1)

IHMAEKSLFQGVARILWGFNIMHAVDEVTGKPIEVKASPHEQAYTDG

FVSFPKNFSARFHVRSSDHESTIRRHYASAQDAWEQQGLEVG* 34625