ࡱ>   bjbjҬҬ 2Ɯ_Ɯ_ 8\F"((((" Tv!j"l"l"l"l"l"l"$%Y(""""""""((h"""""""""((j"""""j"""""""0E""""V""0"""(""(""""(6" """""""""""""""""""""""""""""""""""("""""""""""""""""" X d: Revised Oct. 18, 2007 D. Nelson Some names not previously assigned are now assigned. Some revisions to sequences are made, while some are known but remain confidential. Revised Feb. 9, 2007 D. Nelson Some sequences are given placeholder names like CYP6AEaa until official names can be assigned. There are 51 complete sequences, 9 more are nearly complete, missing only N- or C-terminals or a small internal piece. This is 60 genes with strong, intact or nearly intact assemblies. There are another 12 in closely related gene subfamilies that have all or nearly all exons accounted for, but the exon connections cannot be made from the small contigs that do not overlap. This is at least 72 genes. There are 7 more partials that are less than half a gene at the present time. If these can be completed, that would make 79 P450s in silkworm. This is comparable to Drosophila. Parts of some genes were assembled from confidential sequences. The Beijing Genomics Institute has now set up a database with a BLAST server to make this data public, so I have included it here. SilkDB: a knowledgebase for silkworm biology and genomics Nucleic Acids Research 33, 399-402 (2005)  HYPERLINK "http://silkworm.genomics.org.cn/" http://silkworm.genomics.org.cn/ July 20, 2004 Note: trees have been built and naming is being done, but some sequences are still uncertain. The old CYP301B sequence has had its C-terminal exon changed based on an Apis sequence and it is now CYP49A1, the old CYP49A1 is now CYP49A2 CYP4G subfamily sequences. >CYP4G22 old CYP4Gxx 64% to 4G19 AV404689 Bombyx mori prothoracic gland EST spans two contigs AV405174 Bombyx mori prothoracic gland EST AV404871 Bombyx mori prothoracic gland EST BP183989 P5PG Bombyx mori cDNA clone BP182770 cDNA clone NRPG1026 BP182055 NRPG Bombyx mori cDNA clone BP183011 cDNA clone NRPG1327 BP183771 P5PG Bombyx mori cDNA clone AU004478 EST BP183321 NRPG Bombyx mori cDNA clone BAAB01118673.1 BAAB01085960.1 84% to 4G20 MSYTNAENVVPTSTFSAINLFYVLLVPAVILWYAYWRMSRRRLYELADKLNGPPGLPLLGNALEFVGGSA () DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLIST (1?) GQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFDCHDYMSECTVEILL (1) 234 ETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 431 (0) 988 VIKRKKEEFASGKKPSNLNETATTSEPSTGKLTSVEGLSFGQSSGLKDDLDVDDDVGQK 1164 1165 KRLAFLDLLLESSQSGVAISDEEIKEQVDTIMFE 1266 () 1340 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMET 1516 1517 LRLYPPVPIIARQVNQEITL 1576 () 1680 SNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCV 1862 (1) 1960 GRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPRKRMAKA* 2136 >CYP4G23 old CYP4Gyy 58% to 4G19 59% to CYP4Gxx CK508129 rswdd0_001928.y1 swd Bombyx mori cDNA CK505752 rswcc0_009305.y1 swc Bombyx mori cDNA AV401408 BP122820 BP123076 BP183420 CK509955 CK505752 CK505553 BAAB01050777.1 BAAB01096227.1 BAAB01156775.1 BAAB01003438.1 BAAB01073763.1 BAAB01110168.1 BAAB01050777.1 MTSLVDETEGYHVNSRVIFYPLLGLTTAIWILYRWQQNSHMHKLAELLPGPASIPIFGNALTLMRKNPHE () LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISS (1?) GPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGTTVDILL () ETAMGISRKTQDESGFDYAMAVMK () MCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK () VIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDV () GEKKRLAFWDLMIESSQNGTNKISDHEIKEEVDTIMFE () GHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYL ERVILESLRLYPPVPVIARKLNRDVTI () STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1) GRKYALLKLKILLSTILRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPRKRVPTNVAR* >CYP4G24 old CYP4Gzz 71% TO CYP4Gyy FIRST TWO EXONS ARE JOINED WITHOUT OVERLAPPING EVIDENCE BUT THEY ARE THE ONLY OTHER 4G N-TERM SEQUENCES WITHOUT A PARTNER BAAB01149226.1 BAAB01135847.1 BAAB01073803.1 BAAB01199362.1 MSSLLNYNFEFDVPPIFHTLLLAIMIMWM LHRWQQSSRLFRLGNKLPGPMALPLVGNSLLILGKKAEGW = BAAB01031491.1 VKYALDYSEKYG TVVRAWAGPKLVVFLTDANDVEVILNSQIHIDKSPEYRFFKPWLGEGLLISSG = BAAB01016193.1 XKWRSHRKMIAPTFHINILKSFMGVFNENSKSVVKKLRSEVGKTFDVHDYMSCVTVDILL ETAMGITKTTQDAASFDYAMAVMK MCNIIHQRHYKVWLHFDAIFKLTSLFKKQRELLKTIHGLTNK (0) VIKKKKFMYLQNKEKGIIPPTIEELTKIKDTNDSIMEDSAKTLSDTVFKGYRDDLDFNDEQDV () GEKKRLAFLDLMIESAQNHTCNISDHEIKEEVDTIMFE () GHDTTAAGSSFVLCLLGIHQEIQSKV YDELFEIFGDSDRLVTFADTLQMKYLERVILESLRLYPPVPAIARKLTRDVQI () VTNNYIIPAGSTVVIGTFKIHRDPKYHKNPNVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1) GRKYALLKLKVLLSTILRNYKTTSEISEDQFVLQADIILKRYDGFKIRIEPRNKNHSNTV* CYP4L subfamily sequence >CYP4L6 67% to 4L4 CK535040 EST 5aa diffs BP182824 EST BAAB01121615.1 BAAB01097697.1 BAAB01093085.1 BAAB01107041.1 MYLILLICLLVLVLTVSWWSMLNRICKSNVPGPFPLPIIGNAHQFVVRST (1) EFLGLLKSFTDKYGDVFRVHFFSYPYVLISHPKYAE (0) 932 ALVSSADLITKGRSYSFLKAWLGEGLLTAS 1018 (1) 1506 GPRWRLHRKFLTPAFHFNILQNFLPVFCKKSEILRDKIRRLADGQPIDLFPITALAALDNVAESIM 1688 (1) GVSVNAQQNSESEYVRAIEX () LSQITTLRMQIPLLGEDFIFNLTSYKKKQNIALEVVHGQTKKVIEARRCELEKNNKTNISGTNE () IGIKNKHAFLDLLLLAEIDGKL () 12 MDEQSVREEVDTFMLEGHDTTTSGI 86 85 LVYTLFGLSKHPDIQEKWYEEQLTIFGEEMDRTPAY () NELAQMKVLEWVIKESLRMYPSVP 264 265 LIERWITKDAE VGGLKLSKGTSVVLNIFQMHRNPEVFEKPLEFIPERFDSLEHKNPFSWLAFSAGPRNCI () GQKFAMMEMKVTLSTLVRNFKLVPVDIEPILCADLILRSQNGVKVGFLPRTQSNSKT CYP4M subfamily sequences >CYP4M5 EST BP125511 BAAB01099467.1 BAAB01097680.1 BAAB01039373.1 MFVYLIFIASFFLLIHLAFNY NSKAVMMNKVPGPKLSFILGNAPEIMMLSSVELMKLARKFASRWDGIYRIWAFPLSIINIYNPDDVEVIVSTTKHN EKSSVYKFLKPWLGDGLLISK GEKWQQRRKILTPAFHFNILRQFSVIIEENSQRLVESLEKCIGKPIDIVPVVSEYTLNSIC ETSMGTQLSDKTEDAWKAYKDAIYELGPYFFQRFTRVYLYFDIIFYLTSLWRKMKKPLKSLHG FTSTVIKERKIYVEQNGVKF GEDVNDDDLYIYKKRRKTAMLDLLIAAQKDGEIDDHGIQEEVDTFMFE EHDTTASGLTFCFMLLANHRAVQDKIVEEINYIMGDSTRRANLEDLSKMKYLECCIKESLRLYPPVHFISRNLNEPV VLSNYEIPAGSFCHIHIFDLHRRADIYEDPLVYDPDRFSQENSKGRHPYAYIPFSAGPRNCI GQKFAMIEMKSAVAEVLRKYELVPVTRPSEIELIADIILRNSGPVEITFNKRTK >CYP4M9 BAAB01103156.1 BAAB01142776.1 BAAB01178932.1 57% to 4M5 BY921981.1 EST N-term MWMYFILILLLLLTIHFLLNYNYRARLLRRIPGPRGYFIVGNALDVILSPAELFASTRK NAAQWPNLNRFWSFGIGALNIYGPDEIEAIISSTQHITKSPVYNFLSDWLRDGLLLST GTKWQKRRKILTPAFHFNILKQFCVILEENSQRFTENLKDTEGKSINVVPAISEYTLHSII () 675 ETAMRTQLGSETSEAGRSYKNAICELGNQFVHRLARLPLHNNFIYNLYTLGKQNKH LNIVHSFTKKVIKDRRQYIRGNGGNNFDDEKDTQADEHSIYFNKKKTAMLDLLLKAERDGL IDEIGVQEEIDTFMFE () 1150 GHDTTATGLTYCIMLIANHKSIQVGALRKYID 1245 () 295 GESTRAADIEDLSKMRYLERCIKESLRLYPPVPSMGRILSEEI 423 () 1467 VLDGYTVPAGTYCHIQIFDLHRREDLFKDPLVFDPDRFLPHNTEGRHPYAYIPFSAGPRNCI 1282 () GQKFAILEMKSLLSAVLRRYNLYPITKPEDLKFVLDLVLRTTEPVHVRFVKRNKV* CYP4S subfamily sequences >CYP4S5 66% to CYP4S4 from the moth Mamestra brassicae BAAB01177041.1 BAAB01181662.1 BAAB01048279.1 BAAB01025317.1 AADK01013707.1 MIWAVVLLIIFIFLIWKALEDEENPLDSLPGPERKPIIGATMRFVNLNT () 3009 GEMFIKLREYHAMYGTRYVVKIFKRRILHLSNERDVE (0) 365 VVLSHSKNIKKSKPYTFLSPWLGSDLLLST 454 GFKWHSRRKILTPTFHFNILKSFLEIIKDKSCDLVKRLEEYRGEEVDLMPVISDFTLFTIC ETAMGTQLDSDKSAETSEYKMAILQIGSLLLDRLTKVWLHNDFIFRQFTVGRKFQKCLKQVHSFAHN VIVERKRQRASGRDPTVVAEDVFG RKKRLAMLDLLLEAEEKNEIDFEGIMDEVNTFMFE (1?) GHDTTAVALTFSLMLVAEDDQVQ (0?) DRIYKELQGIFGDSDRRPTISDVAEMKYLEAVVKETLRLYPSVPFIAREITEDFML () DDLKIKKGSEVAVHIYDLHRRKELFSDPEKFLPDRFLNGELKHPYSFVPFSAGPRNCI (1) GQRFATLEMKCVLSEICRSFRLEPRTKGWRPTLVAEMLLRPNEPIHVKFIKRKQS* >CYP4S6 94% to CYP4S5 BAAB01121123.1 BAAB01054179.1 BAAB01073078.1 BAAB01008096.1 BAAB01081659.1 AADK01014846.1 164 MIWTVVVLIIFIFLIWKALEDEENPLDSLPGPERKPIIGAALRFVNLNT 18 () REMFIKLREYHAMYGTRFVVKIFKRRVLHLSNEKDAE (0) VVLSHSKNIKKSKGYTFLSPWLGSGLLLST (1) 1053 GFKWHSRRKILTPTFHFNILKSFLEIIKDKSCDLVKRLEEYRGEEVDLMPVISDFTLYTIC 1235 1966 ETAMGTQLDSDKSAETKEYKMAILQIASLLLNRLTKVWLHNDLIFDQLTVGRKFQK 2133 2134 CLKQVHSFAHNVIVERKRQRASGRDYSVVAEDVFGRKKRLAMLDLLLEAEEKNEIDFEGI 2313 2314 MDEVNTFMFE 2343 () 2862 GHDTTAVALTFSLMLVAEDDQVQ 2930 () 3158 DRIYKELQGIFGDSDRRPTISDVAEMKYLEAVVKETLRLYPSVPFIAREITEDFML 3325 () 578 DDLNIKKGSEVVVHIYDLHRRKELFADPEKFQPDRFLNGELKHPYSFVPFSAGPRNCI 751 () GQRFAMLEMKCVLSEICRSFRLEPRTKGWRPTLVAEMLLRPNEPIHVKFIKRKQS* CYP4AU sequences >CYP4AU2 BAAB01192732.1 CYP325 like N-term AADK01032226.1 1927 MIILLLLFFVASLYWLYWTNKSKRMNKMTASLPVPPTLPILGNATLFIG >CYP4AU2 35% to 4C3 aa 112-276 37% to 4G19 BAAB01022101.1 exons 2,3,4 AADK01025934.1 (1) AIGDPEDAQVVLENCLDKDVVYRFLRPWLGHGLFVAP (1) VCLWKSHRKVLLPVFHNKVVEQYLQMISVQADILVERLNEKANKGEFDVLKYITACTLDIVF (1) ETAMGERMDVQRSPDTPYLRARHTVMTILNMRFFKVWLQPDCIFNLTSYSKQQKDNIDLTHKFTDE (0) >CYP4AU2 62% to CYP4AU1 I-helix to end BAAB01055413.1 AADK01029434.1 Note N-terminal is known but confidential (10/18/2007) Only missing 23-24 aa in the middle between the two segments (1) GKVRPVLDMLFGREIEFTDEQLREHIDSITIAGNDTTALVMAYTLVRLGIHQNVQEKVYLE () QRTIFGDSKRGADKVDVAQMQYLERVLKESMRLYTVVPIIARNVHKDTYL () PRCGVTLPAGIGAVVGPFAIHRSKSVWGPDADEFDPDRFLPERSLNRHPAAFLPFSHGSRNCI () GRNFGMLIMKSIVSTISRSYRIEADELGPLKIEMLLFPIRGHQIRISRRETLA* >CYP4AU-like BAAB01077742.1 Length = 3282 68% to BAAB01022101.1 exon 2 AADK01002646.1 69% to CYP4AU2 2223 AICDTEHAQIILDCLNKDMVYRFLRLWLEHGLFVAS 2330 CYP4AX sequences 50% identical to CYP4S4 >CYP4AX1 CYP4qq 50% to CYP4S4 53% to CYP4Sxx lower case is from CYP4rr BAAB01092965.1 BAAB01135526.1 BAAB01183645.1, AADK01005955.1 AADK01030377.1 (frameshift after GQKF in last exon) MWFSLVVVAVIYALWKLFYKEDDPIDSLPGPTKLPIIGNMLDMFNMTP () GEKFKYERQLSKTYKQRYMQKIFYRRIVYVHHPDDVE () VVLSHSKNITKNVNYDFLKPWLGTGLLLST () GSKWFKRRKILTSAFHFDILKDFASLFEEKSRRLVDQLRANNGEPISLLPVMSNYTLFTLC (1) ETALGTKLDTDRSVAAAEYKDAISKTAQISIYRLPRIWLYIDAIFNRTSAGREFAKNVDIIHSFADN VIVQRKEQRLNSLDKGLVERDEFNRKKRTALLDLLLEAEAKREIDLEGIREEVNTFMFA () GHDTTGTALTFSLMLLSDHEEAQ () ERILEEYNEVMRGKETPTLSEFAEMKYLDAVIKETLRLYPNPHRVGRVLTEDITL (1) GGVPIKAGTEIGVQIIDLHHREDFFPEPEKFRPERFLRGEIQHPYSFVPFSAGPRNCL () GQKF AMLEIKSVLTHICNNFKLVPMKRNWRVETVSDIVLKPAEPIYIKFVPR* >CYP4AX2 CYP4rr 94% identical to CYP4qq lower case is from CYP4qq BAAB01152933.1 BAAB01194854.1 BAAB01058563.1 BAAB01102208.1 BAAB01008375.1 MWFSLLVVAVIYALWKLFYKEDDPIDSLPGPAKLPIIGNMLDMFNMTP () GEKFKYERQLSKTYKQRYMQKVFYRRIVYLHHPDDVE (0) VVLSHSKNITKNVIYDFLKPWLGTGLLLST () GSKWYKRRKILTSAFHFDILKDFASLFEERSRRLVDQLRANNGEAISILPVMNNFTLLTIC (1) ETALGTKLDTDRSVNTAAYKDAISKIGQICIYRLSRIWLYIDAIFNRTSAGREFAKNVDIIHSFADN VIVQRKEQRLNSLDKGLVERDEFNRKKRTVLLDLLLEAEAKREIDLEGIREEVNTFMFA () ghdttgtaltfslmllsdheeaq () ERILEEYNEVMRGKETPTLSEFAEMKYLDAVIKETLRLYPNPHRIGRVLTEDITL (1?) GGVPMRAGTEVCVLTIDLHYREDFFPEPEKFRPERFLRGEIQHPYSFVPFSAGPRNCL (1) GQKFAMLEIKSVLTHICNNFKLVPMKRNWRVETVSDIVLKPAEPIYIKFVPR* &&&&&&&&&&&&&&&&& >AM106362 Lutzomyia longipalpis Jacobina = best EST to these genes MWGKFFFICDGLFWAVFFSPPLRGGLGSFFRGGGRKFPGPFYGS PSLGRLPAQMGFSQKGFLGLPKVILSKITQSNENFGWAEAVC () AYFPPEECQYVFNANECLSRDDIYDYIKPFTGDGLVTLP () AETWKDHRKFLNPCFNLKILQSYMPIFNTEVKTLIGRLGQRIGKGSFDMYDYMDACALDVVC () QTTLGTQMNIQKNENMDYLDAANSLLATMTTRIFNPLYHSDFIFNLSKWAKMEQKNSDITFGFVDNILQR KKAAYKKFQPSDEQNNLDEGTSFKSPQLFIDQLLKLSMEGKYFTDTDVKNEANTIVA CYP6B sequence >CYP6B29 51% TO 6B1 CK494244 EST 57% to 6B27 aa 144-500 BAAB01105883.1 BAAB01064450.1 2461 MAIIYILSASVVLPLLLYLYFTRHFNYWKKRNVPGPKPVPLFGNLMELALRKKNIGIVFKELYENFPNEK 2670 2671 VVGIYRMTTPCLLIRDLDVIKNIMIKDFDVFVDRGVELS*SGLGANLFHADGDTWRV 2841 2842 LRNRFTPLFTSGKLKN MLHLMIERANKYIEHVEMLCDHQPEQDIHTLVQKYTMATIAACAFGLDIDTTDPNKDQLK TLEEIDRLSLTANFAFELDMMYPGVLKKLNSTLFPGFVSRFFKDVVKTIIEQRNGKPTDR NDFMDLILALRQLGDIQATKRNSEDKEYSIELTDELIEAQAFVFYIAGYETSATTMTFML YQLALNPDIQDKVIAEIDQGLKESKGEVTYEMLQNLTYFEKAFNETLRMYSIVEPLQRNA KIDYKIPDTDIVIEKGTTVLFSPLGIHHDEKYYPNPSKFDPERFSPANISARHPCAHIPF GTGPRNCI () 661 GMRFAKIQSRVCMVKMFSKFRFELAKNTPRNLDIDPTRLLLGPKGGIPLKIVRR* 825 CYP6AB subfamily sequences >CYP6AB4 64% TO 6AB1 OVER WHOLE SEQ BAAB01081811.1 BAAB01162324.1 BAAB01031011.1, AADK01009517.1 MLTAAIFVIIVALVYLYSTRTFRYWEKRGIKHDKPVPFFGTDSEGYLLRKSMTQTAVDAY LKYPNEKVIGFFRSSRPELIIRDPDIIKRILTTDFAYFYPRGLNPHKKVIEPLMRNLFFA DGDLWRLLRQRMTPAFTSGKLRAMFPLVVERAERLQSRTLEIASQPLDARELMARYTTDF IGACGFGLDADSLNDEDSAFRKLGAAIFNITVQQAIVAALKEIFPGIFKHFKYSSKYETD FMSLVSSILKQRNYKPSGRNDFIDLLLECRMKGEIVVESIEKMKPDGTSEVVRMELTEQL LAAQVFIFFAAGFETSSSATSFTLHQLAFHPEIQEKVQKELDQVLAKYNNKLCYDAIKEM RYLESAFKEAMRMFPSLGFLIRECARQYTFPELNLTIDEGVGIIIPLQALHNDPEYFDSP NEFRPERFMPSEYNHNKTKFVYLPFGDGPRGCI () GARLGLMQSLAGLAAVLSKFTVKPAPSTKRHPVVEPKSSVVQSIKDGLPLLFIERTKS* >CYP6AB5 BAAB01021567.1 BAAB01206787.1 58% to 6AB3 72% to 6AB2 56% TO CYP6ABxx MISSING C-TERM BEYOND A REPEAT SEQ. possible C-term = BAAB01196051.1 66% to 6AB2 Bmb030331 from Li Bin MFFYLLIVILITLYYYGVR TFDYWKKKGVNHDPPLPFFGNNLRQFMQKASMAMMATETYKKYPEEKVVGFYRGTSPELV VRDPELIKRILVTDFSSFYARGFNPHKKVIEPLLKNLFFADGDLWRLIRQRFTPAFSTAK LKAMFHIITERAEKLQMIAENEAYENFCDVRELMARYTTDFIGACGFGLNIDSLSDENSQ FRKLGKRIFKRDLSDAVRAALKLMFPELCKHLTFLTPELEKSMTYLVQNVIREKNYKPSG RNDFIDLMLELKQKGKLLGESIEAKNANGTPKQVELEFDDLLMTAQVFVFFGAGFETSST ASSYTLHQLAFNPECQEKTQKEIDEVLSKHNNKITYDAIKEMTYLEMAFNEAMRLYPSVG YLVRMCTVPEYTFPEINLTINEDVKLMIPIQAIQKDEKYFKDPERFHPERFSSGAKANLK PYTFLPFGEGPRACV () 923 GERLGQMLSMAGLVAVLQKYTVEPVEISLRDPIPDPTTTVSEGFVHGLPLKLRRRERRI* 1102 >CYP6AB8 96% identical to CYP6AB4 20 aa diffs whole seq known but confidential CYP6AE sequences. >CYP6AE2 Bombyx mori (silkworm) old CYP6AEcc BAAB01091139.1 contig444108, frameshift at 1529 whole gene in one contig No accession number Junwen Ai submitted to nomenclature committee Jan. 31, 2007 nearly identical to sequence CYP6AEcc on Bombyx page except one region from amino acids 106-256 does not match. The EST BY914225 agrees with the Ai sequence so the old CYP6AEcc sequence appears to be a hybrid assembled from two genes. 663 MSVSALVFAAFVLLVTYIYYWSTRKFDYWKRKNVPYAKPVPFFGNYMRYITLQSFLGDVM 842 843 QKLCQQFPDRPYFGSFYGTEPALVLQNPEIIKQVFTKDFYYFNSRENRDYNHKEVFTQNL 1022 1023 FFANGDRWKVIRQNLTPLFSSSKMKNMFYLVEKCNHSLEDMLDKETKDLQSIEIRSAMIR 1202 1203 YTLDSICSSAFGIETNTLSEGAENSPFPSMGSTIFSSSITRGLKLIGRSMWPGIFYKLGL 1382 1383 RCFPTEIDDFFERLLTEVFENRGYKPTNRNDFVDLILSLKQNDYLTGDG 1529 1529 LVPKNVDAKKVTVKVDDALLIAQCVVFFGAGFETSATTLSAALYELAKNPEAQRRAQEEV 1708 1709 DELLLKHNNKLNYDCLAELPYLEACMNEAMRLYPVLPNITREAVTDYTFPDGLRIDKGMR 1888 1889 VHVPVYAIHRNPDNFPDPEEFRPERHLGDAKNDIKQFTYFPFGEGPRICI 2038 (1) 2917 GMRFGKMQTIAGMVTCLKKYNFELADGMSKTVPFRSTTVLTQPSTGLFLKATPRDGWKQRIFAR* 3111 >CK526561 a related EST rswfa0_003045.y1 swf Bombyx mori cDNA. 2aa diffs with BAAB01091139.1, 6aa diffs with CYP6AEbb GFETSASTLSAALYELAKNPEAQRRAQEEVDELLLK 414 HDNKLNYDCLAELPYLEACMNEAMRLYPVLPNITREAVTDYTFPDGLRIDKGMRVHVPVY 235 234 AIHRNPDNFPDPEEFRPERHLGDAKNDIKQFTYFPFGEGPRICIG >CYP6AE3P (old CYP6AEbb) BAAB01174895.1 95% to BAAB01091139.1 54% to 6AE1 there are probably two very similar genes BAAB01172535.1 fills in missing sequence for this contig Bmb026776 from Li Bin MSVSALVFSAFVLLVTYIYYWSTRKFDYWKRKNVPYAKPVPFFGNYMRYITLQSFLGDVM QKLCQQFPDRPYFGSFYGTEPALVLQNPEIIKQVFTKDFYYFNSRENRDYNHKEVFTQNL FFANGDRWKVIRQNLTPLFSSSKMKNMFYLVEKCNHSLEDMLDKETKDLQSIEIRSAMIR 34 YTLDSICSSAFGIESNTLREGGENSPFANMGSIVFSSSITRGLKWISRSMWPGIFYKLGL 213 214 QCFPAEIDGFFER 252 LLTEVFENRGYKPTNRNDFVDLILSLKQNDYLTGDGLVPKNVDAKKVTVKVDDALLIAQC VVFFGAGFETSATTLSAALYELAKNPEAQRRAQEEVDELLLKHNNKLNYDCLAELPYLEA CMNEAMRLYPXXXXXTRETVADYTFPDGLRIDKGMRVHVPVYAIHRNPDNFPDPEEFRPE RHLGDAKNDIKQFTFFPFGEGPRICI (1) GMRFGKMQTIAGLITCLKKFNFELADGMPRTLAFRSTTLLTQPSTGLFLKATPRDGWEQRIFAR* >CYP6AE4 (old CYP6AEaa) BAAB01211364.1 84% to CYP6AEff 53% to 6AE1 missing C-term MLFLTLLFILSVCVYFIY (frameshift) YRVCNRRFDYWRKKNVSFVPPVPILGNYSGYILLKESISKVVHNLCKLFP 2567 2568 NDPYIGAFFGTEPTLIVKDPEFIKLVLTKDFYHFNGREGSKYTHNEVVTQNIFFTYGDRW 2747 2748 KVIRQNLTPLFSSLKMRNMFHIIEKCSGIFENLLDEESLAPEVEMKSLMSRFTMDCIGGC 2927 2928 AFGVDTKAMQEPKDNIFTTMGYLFFESTTYRGIKNVLRAIWPGIFYGLGLKVFPTDLNEF 3107 3108 FSKLLVGIFEARDYKPSSRNDFVDLLLNLKKNRHIVGDRLQKTTTGDEGADSKFELEVDD 3287 3288 GLLVGQCLAFFSAGFETTSTISNFTLYELAKNPDVQKRAQKEVDEYIKKHNNKLDYDCVK 3467 3468 ELPFVEACIDEALRLYPVLGVLTREVMEQYTFPTGLTLDKGDRVHIPVYHLQRDPEYFPE 3647 3648 PELFKPERFYGEEKKNIRPFTYLPFGDGPRICI 3746 (1) >CYP6AE5 (old CYP6AEff) BAAB01096775.1 91% TO CYP6AEee BAAB01211363.1 51% to CYP6AE1 Depressaria pastinacella 86% TO CYP6AEdd AADK01005027.1 MILTIIFILSLCVYILYRISTRKFDYWQKKNVNYVQPTPFLGNYSGYILLKENLL DVVYNLSKLFPNDPYVGAFFGTKPTLIVKDPEFIKLVLTKDFFYFTGKECFEYTHKEVIT QGIIFTYGDRWKVIRQNVTPLFSSSKMRSMFRIIEHCSGVFENLLD EESLAPEVEMKSLM SRFTMDCIGGCVFGVDINAMQEPKDNIFTTMGCLFLETTTSRGIKNVVKAIWPEIFYGLG FKVFPTDIHKFFSKLLVRIFEARDYKPSERTDFVDLLLNLKKNRHIVGDRLQKIKTGDEG ADSKFELEVDDGLLVGQCLAFFSTGFETSSTISNFTLYELAKNPDVQKRAQKEVDEYIKK HNNKLDYDCVKELPFVEACIDEALRLYPLFGVISRQTGERYTFPTGLTLDKGDRVHIPVY HLQRDPEYFPEPELFKPERFYGEEKKNIRPFTYLPFGDGPRICI (1) 11263 GMRFAKMQILAGLVTILKKYTVQLADGMPETIDIEPKAIVTQPAISLRLKFVPRNDLQKRIFA* 11069 >CYP6AE6P (old CYP6AEee) BAAB01091974.1 93% to CYP6AEff BAAB01178163.1 = C-term exon 50% TO BAAB01091139.1 BAAB01149335.1 = N-TERMINAL (MOST PROBABLE SEQUENCE TO COMPLETE GENE) 1055 MILTIIFILSLCVYILYRISTRKFDYWQKKNVSYVEPAPFLGNYSGYILLKENLLDVVHN 1234 1235 LSKLFPNDPYVGAFFGTKPTLIVKDPEFIKLVLIKDFYYFHGREGSKYTHNEVITQGIFF 1414 1415 TYGDRWKVIRQNLTPLFSSSKIRNMFRTIEKCSGVFENLLD 1537 EESLAPEVEMRSVMSRFT MDCIGGCVFGVDINAMQEPKDNIFTTMGCLFLETTTSRGIKNVVKAIWPEIFYGLGFKVF PTDIHKFFSKLLVRIFEARDYKPSERTDFVDLLLNLKKNRHIVGDRLQKIKTGDEGADSK LELEVNDDLLVAQCVSFFIAGFETSSNSLTFTLYELAKNPDVQKRAQKEVDEYIKKHNNK LDYDCVKELPFVEACIDEALRLYPLFGVISR (frameshift) DKRERYTFPTGLTLDKGDRVHIPVYHLHHDPEYFPEPELFN PERFYGEEKKNIRPFTYLPFGAGPRVCI GERFAKMQMLAGLVPILKRYTVRLAEGMPETINFEPKAIASQPNIGVRLNLLPRNN >CYP6AE7 (old CYP6AEdd) 53% to 6AE1 BAAB01210600.1 BAAB01149335.1 87% to CYP6Aeaa Bmb021626 from Li Bin MILTIIFILSLCVYILYRISTRKFDYWQKKNVSYVEPAPFLGNYSGYILLKENLLDVVHN LSKLFPNDPYVGAFFGTKPTLIVKDPEFIKLVLIKDFYYFHGREGSKYTHNEVITQGIFF TYGDRWKVIRQNLTPLFSSSKIRNMFRTIEKCSGVFENLLDEESLAPEVEMRSVMSRFTM DCIGGCAFGVDTNAMQEPKDNIFKTMGYLFFESTTHRGIKNVFKAIWPEIFYGLGFKVFP TDLNEFFSKLLVGIFEARDYKPSSQNVFINLLLNLKKNRHIVGDRLLKIKTGNVRAESKI KLEVDDELLVSQCVAFFIAGFETSSTISSFTLYELAKNPDVQKRAQKEVDEYIKKHNNKL DYDCVKELPFVEACIDEALRLYPVLGVLTREVMEQYTFPTGLTLDKGDRVHIPVYHLQRD PEYFPEPELFKPERFYGEEKRNIRPFTYLPFGAGPRTCI (1) GQRFAKMQMLAGLVTILKRYTVRLAEGMPETINFEQRAIVTQPNIGIRLNLLPRNN* >CYP6AE8 (old CYP6AEgg) 53% to 6AE1 BAAB01205437.1 BAAB01169820.1 (52% to BAAB01211364.1) BAAB01196919.1 contig74655, 50% to 6AE1 might be the last exon MFLLINICVILFVIYYLVTKKYSYWRNRNVSHEKPVLLLGNYGDLILQKKNFGEMAQAIC 1747 QKFPGEPVVGAFFGTEPVLIPQDPEVIKTILTKDFYYFNGREISEHVHKELLSYNLFA 1574 1573 TYGDEWKILRQNLTPIFSTAKLKSMFTLIEKCSKSFQNLLEDETKISKELEVRTLMQRFT 1394 1393 IECIGSCIFGVDTDTLGNDKMNPFKAAGSQLSDFSRLVFVKGIVRAIWPTLFYALGFKTF 1214 1213 TTELDIFKKLVNAVFAQRKHKPTTRNDFVDLILTWKNNNTITGDSIGSFKNSDKTKFSI 1037 1036 DVNDDLLLAQCLVFFAAGFETSAMTSSYTLHELAKNQRALKKACDEVDAYLLRHGNKV 863 862 NYDCVTELPYLEACIEETLRLYPVLGIITREVMEDYVLLDKIHLKKGDRIHVPVFHLHH 686 685 NPEHFPNPEEYRPERFYGEEKRKVKPYTYLPFGEGPRICI 566 () 2262 GMRFAKMQSIAGLITILKKFRLELPEGAPTKIEFKPEAFVTTPKDLIKIKFLEREGWQQRVF 2077 >CYP6AE9 (old CYP6AEhh) BAAB01207183.1 BAAB01033068.1 50% TO CYP6Aedd Bmb007891 from Li Bin 530 MYLLTFLLHFILFLVLVVYYITKRNHDYWKNKKVPFEKPYPILGNYGDYILLKIF 366 365 FGNVTKRLCEKFPESPYVGTFYGTEPALVVQDPDLIRLILVKDFFYFHGREVCKYVDREI 186 185 TTQSIFFTYGDDWRVLRHSLTPLFTTSKMKN MFHLIKNCCRVFENVLEEKATVKSFEINSIIKYFIMDCVGACLFGVEINAMEKHSQNPIV KISKEIFPKSTTRGIINVLRGIWPSLFYALRLKLFPEVITMFFTDLLECAFKDRQRNLSQ RQDFIDLFMKLRQNKYLVGDSIPDIKNGRVQKVNLEVTDELLIAQCVSFFGAAFETSSTT LSLTFYELAKNPKYQKKAIEEVDDYFAKHNNEIEFDIVSDTPYLNACIDETLRLYPSLAN LTREVMEDYTFPTGLKVEKGTRIHIPVYHLQRNPKYFPEPNKFDPRRFLPEAKQTIYPFT YMPFGEGHRICIAMRFAKMQMLAGFATLLKKYEVAVDDTTPQELTIDPRIIVTTPIENIQ LKLIARQHAL* FOUR NEARLY IDENTICAL C-TERMINAL EXONS FOR CYP6AE SEQUENCES. >BAAB01132789.1 Bombyx mori DNA, contig535134, whole genome shotgun sequence Length = 2056 352 GMRFAKMQILAGLVTILKKYTVQLADGMPETIDIEPKAIVTQPAISLRLKFVPRND 519 >BAAB01134380.1 Bombyx mori DNA, contig538543, whole genome shotgun sequence Length = 2850 218 GMRFAKMQILAGLVTILKKYTVQLADGMPETIDIEPKAIVTQPAISMRLKFVPRND 385 >BAAB01199026.1 Bombyx mori DNA, contig760785, whole genome shotgun sequence Length = 626 460 GMRFAKMQILAGLVTILKKYTVQLADGMPETIDIEPKAIVTQPAISLRLKFVPRN 624 >BAAB01136322.1 Bombyx mori DNA, contig542966, whole genome shotgun sequence Length = 1880 1736 GMRFAKMQILAGLVTILKKYTVQLADGMPETIDIEPKAIVTQPAISLR 1879 Other CYP6 family like sequences >CYP6AN2 65% to 6AN1 join with BAAB01065359.1 C-term exon 67% to 6AN1 Bmb032387 from Li Bin 361-441 65% to 6AN1 AADK01063079.1, AADK01036854.1 Whole sequence known but confidential KEIQCEIDEVLSRHDNKLCYDAILEMPLLT MAFKEALRMFPSLGNLHRVCTRSYTIPELGITIDPGVRIIIPAQAIQNDAKYFDDPSEFR PKRFAKDSEIKKFSFLPFGAGPRNC205 GARLGEMQSLAGLAAILHKFSVEPAPSTVRKLRVKHTQNVVQGVEGGLPLLIKERK* 375 >CYP6AU1 new subfamily 40% to 6B1 43% to 6B27 BAAB01129923.1 AADK01004964.1 MLTAYLLYVFASIVVLIYFYLNNKYKYWKNKNIAGPEPEFLFGNLKESFHRRKHIATVFK EIYDQYPDEKVVGMFRMTSPTLIVRDLDIVKQIMIKDYAKFNERGIKFSKEGLGDNLFHA DADAWKAVRSHLTPMFSSGKLKNMVRVLSQTGDRFVDHVTNEVRLRPEQELVSLFLKYNI ATIMACSFSMETDINDMQVYEMLNVAVFENSYISELDMVFPGILRKTNRSIFGPTVNNFC YEIVEFIKNERNGKPANRNDMMDMLLGVNCDKLKMKNGSEDFVEITEHVMAGQVFVFFAAG YVNNTITLTFSLYHLAKDQSIQ ERLMREIETVLENHNNVLTLEAINEMSYLEMIYLETLRMHPTTNTLQRSALEDYTIP GTDIEIEKGTLVLIPPLAFHHDEKIYPEPEKFDPERFSVENHKSRHACAFLSFGIGPRTCIG >CYP6AV1 new subfamily 44% to 6AB1 BAAB01020563.1 BAAB01140967.1 Bmb035757 from Li Bin MLLLIIVIIILYLYTTRNHSYWAKRGVKHERPIPFFGNHLPNILLQRDNTDLGLQMYNAY ENEKIVGYYIGNIPQLIIRDPEIIKHMLNIDFNSFSERGLNLNPKKESLLNNLFFVSG DNWRRMRNIFSGAFTSVKLKAVFPLIVKCTDKLVKKTTMRHVSDEIKTYELMTGYTMEFIAS CGFGVDVDTISESNMHFVDVARSFFDKTSLQTFMINLDEICSILKIIPGTFEVNSEFNSF ILNITKKVLAERNFKPSERNDFVDHLLQMVYWNGNEKLTTEADLESDSWFVAAQVFLFLV AGFETSAVATSVVLHQLAYNQNLQDEVRKEIDSALKKYDNKLCYEAVCEMSLLDMTLKES LRIQPPAGFIRRRCIKEYKIPGTNIAIDPGVKILIPIKALNHDPKYFDCPSEFRPQRFSP EAEQNIPKFVYMPFGSGPRTCP () GARLASLQSMAGLASLLHHFVVEPTPNTSRHYKIKRSAFLVQIIEGGIPLYFKPRTNK* 3673 >CYP6AW1 new subfamily 39% to CYP6P5 aa 125-502 BAAB01195862.1 BAAB01153386.1 CK496233 EST AADK01000856.1 MWLSVLLVVILLFLILLLTVFHYTTKGRKYWLLRNVPYREPCPLFGNFGATFTMRRSYTK MLQFFYDNYYNEKYVGIFQARRPTLMLIDLELVKNVLSKEFPNFSDRISVTTDTQREPL LRNLANMSGAEWKAMRQIVTPTFSSAKMKAMFPLIAECAQTLKNSLLKESLAEVNVPDFMTRFTTD VIGSCAFGVDPGSLKDPESPFLKMSQKMFKIDRSTVLKRYCRTFFPKLFKFLNLRTYSKD VETFFTTIIKKVLDERRATGVQRHDFLQLMLNVQKTETSFVMTDTLIISNSFIFMLAGLE SSSTTLSFCLYEWAKDKHIQDDLRTEMVDCLERYGGINYEAVCSMRWVN QAVLETLRLHPPTPLTTRLGTSACTLNGTDLSVRVRDPVLIPLYCIQRDAQHFPNPDKFNLERFKETNPPG FLAFGEGPRSCPGARFAQLTVAAALAALLSSFEIEPCSMTTSTIVYDPRSVMLKNKGGIW LKFVPL >CYP354A1 Bombyx mori (silkworm) BAAB01200346.1 BAAB01118814.1 BAAB01157630.1 BAAB01008306.1 Bmb029934, Bmb010351 from Li Bin AV399740.1 EST N-term 203 amino acids BAAB01211873.1 exons 1,2 AADK01025884.1 exons 3,4,5,6 BAAB01157630.1 exon 7 AADK01034838.1 exons 7,8 AADK01018486.1 exons 8,9 This sequence assembled from genomic DNA and ESTs A tree of 155 CYP6 and 9 sequences places it outside CYP6 and CYP9, but It is a CYP3 clan member. The stop codon in exon 4 seems to be a seq error when compared to the CYP354A2 cDNA sequence. MNFSPGTVQILQFIQNDWKL 605 ILILTLLIFIYYYYTNTFDYFEKRGVPFKKPIIFLGNLGPRLKAVKSFHQYQLDIYQYFKGHPYG (1) 799 1277 GTFDGRRPVLHILDPELIKAIMIRDFDHFTDRNTLNSMEPRYLSRSLLNLK (0) 1429 4244 GLEWKGVRSTLTPAFSSSRLKNMIPLIQQCSKQMVEFLKKF (1) 4027 2588 DGKEIEMKQTMGHFTLEVIGACAFGIKCDALSNENSRFVK (0) 1717 VAEKFDYMPKYKRVILLMLLVFMPKMIR*LRLSFLNIEYTG 1598 ELVRMLQAAKAERRSSESK (2) KGDFLQILIDFAAKETAQNDTAKREI (1) LLDDDTIDAQSLLFLIAGY ETSSTLLSFAIHVLATKPDLQETLRAHVQEMTKGKEMSYELLAQMDYLEAFLQ (1) ETLRIYPPVARVDRICTKPYIIPGTTVHVGV GDAVAIPVYGLHMDEDIYPEAREFKPERFMDDQKKDRPSHLYLPFGAGPRNCI (1) GLRFAMISAKIAMVALMKNFKFSVCSKTMDPIDFDKRAVLLKSAKGLWVRIELIDLS* >CYP354A2 AB265182.1 Antheraea yamamai FTLEVIGACAFGIKCDALSHENAYFYKVAENFDYMPKIKRVLIF LCMIFMPKLLTYLNVSFLHLKSTDELVRMLQAAKAERKRLNSRENDFLQILIDFAKKE YTELENTNTAKYLDDDTIDAQCLLFLIAGYETSSTLLSFAIHELAINTQLQSKLRAHI KEVTDGKEISYELLSELTYLDGFLLGDAVAVPVYGIHMDPKYYPEPHELRPERFMHSE KKERPSHLFLAFGSGPRSCIGSRFAMISAKTAMMSLMKNYKFSTCSQTTYPIEFDKRS VLLKSETGLWVRFEPL CYP9A subfamily sequences. >CYP9A19 old CYP9Aqq 66% to 9A13 BAAB01209004.1 BAAB01182505.1 BAAB01064142.1 BAAB01170681.1 BAAB01057984.1 BAAB01037494.1 Bmb022413 and Bmb022414 From Li Bin MIIIIWTLVIGLALLLYLKQTYSYFSKHEIKSVTPLPILGNMGKIVFKFNHLVDDISQLYNNFPEER () FVGRYEFVNPVIYIRDIEIVKRITIKDFEHFLDHRTIVNEDSDPMFGRNLFSLK () GQEWKDMRSTLSPAFTSSKMKLMMPLIVEVGEQMINAIKENIKNS () GVGYVDIDTKDLTTRYANDVIASCAFGLKVDSLTEENNRFYAMGKAATNFSFKQILMLLGFISFPKLMK () MTKFRLFSEETSGFFKELIMGTMKDREMRKIIRPDMIHLLMEAKK () GKLVHDNKSSKDTDAGFATVEESAVGKKQIDR () VWTDDDIIAQAVLFFIAGFETVSSAMTFLLHELALNPEVQEKLVEEIKENKERNNGKFDYNSIQNMAYLDMVVS () ELLRLWPPAVSMDRICVQDYNLGKPNDKAKRDFI (0) LRKGTGVAIPVWAFHRNPEFFPDPQKFDPERFSEENKHNIKPFTYLPFGVGPRNCI (1) GSRFALCEVKVMAYQLLQHMEISPCEKTCIPSKLSKEIFNLRLEGGHWVRLKIRD* >CYP9A20 old CYP9Arr 65% to 9A13 BAAB01013356.1 BAAB01000958.1 BAAB01096964.1 BAAB01123933.1 BAAB01125489.1 BAAB01165057.1 CK511220 EST may be a hybrid sequence 68% to 9A13 joined Bmb025541, Bmb025542, Bmb025543 MILLIWAVVLIAAFVLFYKQAYSLFSKHGVKGFTPLPFFGNMGRIVIKMDHFSDHIQSLYDSFPEER () FVGRYEFLNPMVIIRDIELLKKITVKDFEHFLDHRTIINKDTDPFFGRSLFFLR () DQDWKDMRSTLSPAFTSSKMKLMMPFIVEVGEQMNKALKQRIQEAG () VGYVDIDSKDLTTRYANDVIASCAFGLKVDSITEENNQFYAMGKAASTFNFRQLLIFFGLASVPKLV () KILRITLFQKEIKTFFRELILGTMKNREAQNIIRPDMIHLLMEAKK () 1129 GKLRHDEKSTKDSDAGFATVEESSVGKKDINR 1224 () 1878 VWTDDDLVAQAVLFFVAGFETVSSAMTFL 1964 LHELALNPEVQEKLVEEIRENEKNNNGKFDYNSIQNMVYLDMVV SEVLRLWPPVIALDRMCVKDYNLGKPNDKSKEDFI () IRKDVAVGIPVWGLHRDPEFFPNPLKFDPERFSEENKHNIKPFSYMPFGLGPRNCI () GSRFALCEVKVMTYQLLQHMEISPCEKTCIPSKLSKETFNLRLEGGHWIRLKIRN >CYP9A21 old CYP9Ass BP115106 EST BAAB01063049.1 BAAB01018306.1 BAAB01114672.1 BAAB01001005.1 BAAB01079446.1 joined without overlapping fragment, but = complementary frags could be a hybrid of two genes 66% to 9A13 MIIIIWTLAIGLAFLLYLKQIYCYFSKHEIKSITPLPILGNMGKIVFKINHFVDDISQLYNKFPEER () FVGRYEFVNPVIYIRDIEIVKRITIKDFEHFLDHRTIVNEETDPIFGRNLFSLK () GQEWKDMRSTLSPAFTSSKMKLMMPLIVEVGEQMINALKKNIKNSG () VGYVDIDTKDLTTRYANDVIASCAFGLKVDSLTEENNQFYAMGKAASNFSFKQILLLLGFISFPKMMK () MTKFTLFSEETSGFFKELIMGTMKDREMRKIIRPDMIHLLMEAKK () GKLVHDDKSSKDTDAGFATVEESAVGKKQIDR () VWTDDDIIAQAVLFFVAGFETVSSAMTFLLHELALNPEVQDKLVEEIKENKERNNGKFDYNSIQNMVYLDMVVS () EXXRLWPPGVSLDRLCVQDYYLGNPNEMAIRDFI () LRKGTGVAIPVWAFHRNPEFFPDPLKFDPERFSEENKHNIKPFAYLPFGVGPRNCI () GSRFALCEVKVMAYQLLQHMEISPCEKTCIPSKLSKETFNLRLEGGHWVRLKIRD >CYP9A22 old CYP9Att 75% to 9A14 aa 421-529 BAAB01150296.1 AU002409 BAAB01097088.1 BAAB01211661.1 72% to 9A12 cannot walk upstream any futher join with N-term from BAAB01034175.1 (might be a hybrid seq) MITLIWLGVLLVTLTLHLRKVYSRFKDYGVNHFTPIPVLGNAGPITVRLRHVAEDFDMVYKAFPEDR (2?) FTGRFDLLRPTVIIKDLDLIKQITIKDFEHFLDHRALVDDTADPFFGRNLFSLR () GQEWKDMRSTLSPAFTSSKMRGMVPFMVEVNNQMIDMIKKKIVANA () GYLDCEGKDLTTRYANDVIASCAFGVKVDSHTNEENQFYLMGRDMADFGFRKIMVFLGYSSFPKLMK () KFNAKLLSDETGHFFTDLVLRTMEDREVKEIVRPDMIHLLMEAKQ () GKLSYDEKSTKEADTGFATVEESDVGKKTINRI WSNTDLIAQATLFFVAGFETISSAMSFALHELALNPEIQDRLVQEIKENYAKTGGKFDFN CIQDLTYMDMFVSEVLRLWTPVVGMDRLCVQDYNLGRANKNATKDFI () LRKGEGLSIPTWSIHHNPEYYPEPYKFDPERFSEENKRNIKPFTYLPFGTGPRNCI () GSRFALCEVKVMLYQLLQQIEVLPSDKTKVRAKLAKDTFNVKIEGGHWIRLKLRD CYP9G subfamily sequences >CYP9G1 intact sequence submitted by Manabu Kamimura 3/22/99 BAAB01081406.1 BAAB01087326.1 BAAB01125517.1 first exon (69 amino acids) known but confidential Bmb008984 from Li Bin RYVGFTDGVCPGIFIRDPEIIKHVTVKEFDHFVNNKDLSPEGEESILKNSLIMLK (1) DEKWRKMRAALSPAFTASKMREMVPLITEISHNIVEYLK () EHLTEDIDLDDLMSRYSNDVIASAAFGLQINSLKERDNIFFKAGKDVFNFSLFQSIRMIFSDHFPSLSK () KLGFTVIPKSTSEFFRTLIASTVDYRIKNKVERRDMIQLLMQLST (1) EWTETELAAQLFVFFVAGFETTGNTLINCIHELALNPHIQDILYEELKAFKETKGNLVYENIGELKYLDCVLN () ETMRKWSAAIFVDRICTKPYVLPPPREGGKPCQ () LKPGEVIYNAVNSIHMDPKYYEEPEKFIPERFLDENKHKIKPFTFMPFGVGPRYCI () GSRFALMEMKILLFRLMLNFKVLKCAKTLDPIKMSPVGFNMNIWGGSWVKFQARKA* >CYP9G3 59% to 9G1 C-term corrected by EST CK508550 BAAB01034600.1 N-term corrected by EST BP125176 AU000984 CK510649 (4 aa diffs) BP127468 BAAB01164136.1 BAAB01189844.1 BAAB01100167.1 GTLK exon is extra compared to CYP9G1, but it is seen in ESTs The length of this sequence in other insect species ESTs is highly variable. MLVEVIVFLITTLVAYYLYVYKKIHYFYDARGVKYQPGIPVLGNILKSSLGTGHFWEDIDKIYKAFPGER () YIGYIEGTTPILMIKDPEIIKNITVRDFDHFVNHKEFFPVEIDALFGGSLFMMK () DDKWRDMRTTLSPAFTGSKMRLMLPFMIDISKNIVEYLK () GHQLEDVDVDDLMRRYTNDVIASAGFGLQVNSLVDKDNEFYECGQAMFSTSWPQRFKMILAAQFPTLAK () KIGIKVFPQKVTRFFREIVTSTMDYRLKNNVERPDMIQLLMDAYK () GTLKNESNESDEKNVGFAMTEEMLKPKGNVR () KWTQDELTAQVFIFFLAGFESSANGLTLCIHELALNPEAQEKLYEAIIKFKEEKGPLTYDNIGELKYLDCVLN () ETSRKWSAAIIVDRVCSKPYELPPPREGGKPYK () LQPGDIVYNSVNSIQMDPEHHPDPEKFDPDRFLDENKHKIKPFTFLPFGAGPRNCI () GSRFALLELKVLIYYIVLNFKIIKTEKTLSPIKLQPGEFNIKVWGGTWTQFEARE* >CYP9G3-de9b10b BAAB01034600.1 pseudogene detritus exons downstream of CYP9Gxx 2492 DFLFNVANSIHIDPIYHTEPDTFNPARFLVENEYQMREFTFMPFSIGPRNFF 4065 GKGFALL*IKLILYYLVLNFKVMKFMKTQNPIKLIQHEFNLEV 4193 Other CYP9/CYP6 like sequences >CYP9AJ1 N-term 34% to 9A20 N-term, 76% to EB742536.1 Antheraea mylitta AADK01023492.1, AADK01016060.1, BAAB01077546.1, BAAB01122451.1 Whole seq is known but confidential 3622 MLWYVVLIVTCLFYYSSRRLRYFSSRGIATLPTTPFFGNLTAVTFGRENFVEAIAKGYDAFKD 3458 () 1564 RYFGLYQYLVPTLVPRDPELIRQILVRDFSAFADRGVHIDEECDPLFGRNLIMLR 1400 4355 GSKWRSMRVALSPAFSGARCRNMAPLMVESAKSVTNHLQKRIIDEKVIDINV (0) 4200 3464 ITMSYVNDVIASCAFGFAVDSLKEPDNCIYKLGQKAIIQDTTQVMKFFGYENIKTVMK 3290 VNPRLEYILGILKTQKKASKXXXXXXXXXXXXXX RPDFIQILVDAMQGMLIYE (2) 2694 >CYP9AJ1 BAAB01063629.1 CYP9A like I-helix region (1) 617 FTDDDLVAQAVLFYVAGYDTTANLINYFLYEMAVNPHVQEKLNQEIAEMSDEGDVYEAIQRLKYLEMCVC 408 (1) >CYP9AJ1 C-term BAAB01173477.1 BAAB01146424.1 BAAB01001094.1 41% TO 6G2 374-514 45% to 9E2 Bmb023483 from Li Bin AADK01003334.1 MSPQPNNLSPLDILINVNKIYKTKYIKYIKLVEPHSVNE EVLRLWPLVGSADRRSVIPYDFGPTYPDSKHSLI APTGIHIWIPIYSIHRDEQYWPDPNTCIPERFSPENKGSIVPYTYLPFGTGPRHCI GSRFAILAAKVFLVKFLKTYRTKTHREKTKLSPRAFILRPRDGFELTVERRIEND >CYP9AJ2 Antheraea mylitta (wild silkmoth) from fat body EB742536.1 76% to AADK01023492 seq above RYFGLYQYLVPTLVPRDPELIRQIMVRDFHAFADRGVHISADCDPLFGRNLIMLT GSNWRSMRVSLSPAFSGARCRCMAPLMADTARAVAQHLKHHITHEQLIDINT ITMAYVNDVIASCAFGFAVNSLEDLQ NGIFRLGQRAIVQDTT CYP12 or CYP333 like mito sequences. CYP333 seems to be the lepidopteran (moths and butterflies) equivalent of CYP12 in flies and mosquitos (diptera). These sequences will probably be in CYP333. There are at least four different C-terminals here and some N-terminal fragments, but it is not clear which N-terminals belong to which C-terminals. >CYP333B1 39% to 12B2 mito BAAB01158176.1 BAAB01035519.1 BAAB01083643.1 BAAB01120305.1 39% to 49A1 39% to 12F2 47% to CYP333A1 75% to combined (BAAB01158865.1 + BAAB01136746) N-terminal is upstream of a repeat seq. I cannot identify it. Bmb006234 from Li Bin AADK01000081.1, AADK01010165.1, EST BJ985225.1 MIIALHYSKLRPVLNFSCLQQCVR () TVTVSAATEKLQQTELKSFREIPGPSSLPIMGPFLHFMP GGSLHNINSTELTHKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGI ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSD () HGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERL () RSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQ MFVLSNELDLKPSIG (1?) QLNYTKNIFKTRLIYFSLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDT (0) TSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSYLRACIKEAMRILPVV SGNMRRTTKEYNILGYHIPEN () VDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCI () GRRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIFKDL* &&&&&&&&&&&&&&&&&& >CYP333B2 BAAB01158865.1 AADK01000081.1 BAAB01179470 BAAB01136746.1 BAAB01210389 whole seq 61% to 333B1 MIGLYILFITFFFLFQNLIYCQ (1) ATVSTSENVDVTNLKPFHEIPGPSSLPLIGPLLHFIPG (1) GSLYTPDTKDFSAKLFKLYGPIVKLDPLFARNTLLMVYDPESAAN (0) VLRSENRIPYRGGFNSLAYYRKHIKKHENNHKKLTGLITE () GEEWWDLRSTVNPVLLQPKTIKLYSAAIDEVAQEMMNR (2?) MHRKLDENDRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPEKKLIECVHQI 1459 FNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEE 1358 () 545 LSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDT 390 (0) 176 VANSIAATLYLFAKNPEKQEKLREEVMSKESKRYLKACIKETMRMMPVVSGNLRRTT 4119 KEYNILGYHVPKG 4081 (0) 3451 IDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 3281 () 2571 GRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYFTGPFNFVFNDIKKK* 2410 &&&&&&&&&&&&&&&&&&& >CK494024 EST seq for N-term KYG motif CK493643 CK540020 BAAB01054952.1 BAAB01013929.1 BAAB01206514.1 28% to 49A1 MKMAKSTVVIRQSL (2) LQRQCRRHIAGSSSSRTSTSPQRRNAAATASATATCLKPFNEIPGPMALPMLRHSAHILPKI (1?) GNFHHTVGLDVLENLRKKYGDLVRLSKATRTRPVLYVFHPEMMRE (0?) VYES A middle region fragment >BAAB01019704 Length = 2835 CYP12 like WALES motif (at ETAM site) 42% to CYP49A2 1227 RLEELRCKGNVLNEELETEIYRWALETVGMMLFGIRLGCLDARYVTQSMHTF 1072 &&&&&&&&&&&&&&&&&&&&&& >CYP333A2 BAAB01120524.1 Length = 1355 38% to CYP49A1 C-helix region 126 VYRAEEANPLRPGFQVLDYYRTQLRKSRYGGLHGLINA 239 () 1099 QGPEWREFRTKVNPALLLPKLVKLYAPGIDEIAQDFVQRYLFSFVIKYYNCVCNFLCSSIIPLR 1290 >CYP333A2 mitochondrial P450 CYP333 family I-helix aa 294-337 BAAB01104455.1 61% to CYP333A1 3 DNFELELTKFSLEATALVALGSRLGCLKDSLDSDHPARRLMKSTRDIFELTYKLEIRPSP 182 183WRYIATPAYKMVIEAYDTQWE 245 () VSKYYFRISMMYINHARKKLEQRGYDIPEEEKSVLEKLIAIDEKVAVMMASEMLLAGIDT 753 strongly suspect these two fragments are part of the same gene with one exon missing between them from the AGIDT MOTIF TO THE PKG MOTOIF. >CYP333A2 BAAB01160330.1 Length = 986 also ovS022C05f from KAIKOBLAST aa 262-365 75% to CYP333A1 BY922830.1 482 IDVIAPNEYLSRSEKFYPQPEEFIPERWLVEKSDPLYYGNAHPLVTLPFGFGVRSCIGRR 661 662 IAELEIELLIKRLIEEFKVTWNGPPIKIVNKLTNTFVKPYNFTFTSVK* 808 &&&&&&&&&&&&&&&&&&& A related Ips pini sequence (NOT BOMBYX) >CB407630 JH III-treated male I. pini midguts Ips pini cDNA 40% to 12F4 CYP12 like sequence from Ips pini (North American pine engraver) (N-term) MLCSKSFSPLIVLRNNSTISAAGVNSFKKAEVVDNAKPEGWDQAKPFDQIPGIKP LPLIGNNFRFLPGGEFHKVQGLDITRRLQQKYGRITTLSGLFGVMPIVHLFDPNDFEHVL RNEGPWPIRKNVECVTYYRQRVRPEIFKGVDGVALTQGEEWLRERSVVNKILMQPRTIEM YVGSMNEVANDLLELMKHFAKKDPNSEMPDNFQNELYR >CB408781 JH III-treated male I. pini midguts Ips pini cDNA Length = 464 WALES region to I-helix. These two Ips pini cDANs probably are from the same gene. They overlap by 2 aa and are the right size to cover a CYP12F sequence exactly in this region. 2 YRWTLESVGVVAYNRRIGCLDINMHKDSEGSRFISAVQEFFDLMYALEYRPSMWRIYSTKKW 187 188 KRFVELMDFITEINQRYINECLATIDPNSDIPDHERSALERLFKVDQQIAVVMASDMLVAGVDT 379 Joined sequences 37% to 12F1, 36% to CYP333B2 MLCSKSFSPLIVLRNNSTISAAGVNSFKKAEVVDNAKPEGWDQAKPFDQIPGIKP LPLIGNNFRFLPGGEFHKVQGLDITRRLQQKYGRITTLSGLFGVMPIVHLFDPNDFEHVL RNEGPWPIRKNVECVTYYRQRVRPEIFKGVDGVALTQGEEWLRERSVVNKILMQPRTIEM YVGSMNEVANDLLELMKHFAKKDPNSEMPDNFQNEL 2 YRWTLESVGVVAYNRRIGCLDINMHKDSEGSRFISAVQEFFDLMYALEYRPSMWRIYSTKKW 187 188 KRFVELMDFITEINQRYINECLATIDPNSDIPDHERSALERLFKVDQQIAVVMASDMLVAGVDT 379 CYP15 like sequence >CYP15C1 40% to CYP15 made from non-overlapping pieces, may be hybrid note: CYP15A1, B1 and C1 are all probably orthologs. Each species seems to only have a single CYP15. (not found in Drosophila) BAAB01071346.1 BAAB01157546.1 BAAB01036905.1 BAAB01022841.1 BAAB01157214.1BAAB01068330.1, AADK01010670.1, AADK01007973.1 MLALIALCFILFFYIISRRHRGLCYPP (1) 2393 GPTPLPVVGNLISVLWESRKFKCHHLIWQSWSQKYGNLLGLRLGSINVVVVTGIELIKEV 2214 2213 SNREVFEGRPDGFFYTMRSFGKKL 2142 (1) GLVFSDGPTWHRTRRFVLKYLKNFGYNSRFMNVYIGDECEALVQLRLADAGEPILVNQMFHITIVNILWRLVAGKR () YDLEDQRLKELCSLVMRLFKLVDMSGGFLNFLPFLRHFVPRLIGFTELQEIHNALHQYLR () YQEIIKEHQENLQLGAPKDVIDAFLIDMLESQDDKR () ATLDDLQVVCLDLLEAGMETVTNTAVFMLLHVVRNEDVQRKLHQEIDDIIGRDRNPLLDDRIR () MVYTEAVILETLRISTVASMGIPHMALNDAKLGNYIIPK () one exon not identified 326 GKRRCIGEGLARSELFMFLTHILQKFHLRIPKNEPLPSTEPIDGLSLSAKQFRIIFEPRKTFKSI* 523 CYP18A1 sequence and a related sequence >CYP18A1 60% TO CYP18A1 ORTHOLOG AU005208 EST BAAB01190855.1 BAAB01187772.1 Bmb024372 from Li Bin MITMLTNSKILWALWQVMNYCVSRTSVMLIIVTCTALLLTQFLKLVRDIRKLPP GPWGPPVVGYLPFLGVRHKTFLQLARNYGALFSARLGNQLTIVMSDYKIIREAFRREEFTGRPSTPLMHTLDGL () GIINSEGRLWKNQRRFLHEKLREFGMTYMGNGKKLMEDRIQ () NEIHELIVSLHRAQGAPIDVNPLLALCVSNVICGITMSVRFSNGDVRFERLNHLIEEGMRLFGEVHYGEYIPLYN () YLPGKALAQEKVAKNRDEMFAFYQTLIDEHRETLDINNARDLIDVYLIEIEKAKSEGRAGELFEGRDH () ELQLKQILGDLFSAGMETIKSSLLWMIVFMLRNPDVKRRVQEELDAVI GRERLPSIDDISSLPYTETTILETLRLSSIVPLATTHSPTR () DVQINGYKIPAGSQVIPLINCVHMDPNLWDEPNKFNPSRFIDATGKIRRPEYFMPFGVGRRMCLG DVLARKEMFMFFSCMMHQFDLEMAEGDALPSLEGIVGATIAPKAFRVKFLARSPVPLVPTTLSADSSHLRHVGSH CYP18B1 sequence >39% to CYP18A1 BAAB01081335.1 BAAB01007952.1 BAAB01142048.1 BAAB01138082.1 BAAB01045663.1 note: this sequence is made from several non-overlapping contigs. MLIYTRIISTLGMWTKLDTYIELYNGYMQDILDRKHRTMDLLFLVLLGLLFLFLKRTICYYMYLPP (1) GPWGVPFLGYLPFMKSSPHAMYSRMADKYGEISSIKLGNHLVVCLNSPKLVKELFS RSDSIARPRTPLNEIMEGR (1?) GIVLSEGILWQKQRQFLHEKFRALGVKVWPKQRFEKFII (0) 1739 MEIEEFITDLIKLNGAPVDPTLLLGRHVHNIICQLMMSFRFEEDDQEFGIFNEKISRGMKL 1557 1556 YGSIHASEYVRHYL 1515 (0) KLPGKKTILDEMKRSLADISEFHANKIRERIDYRATHPYDEPADLLDYYLDNIEARKSRKRFPDIFPGVDP (1) EKQVVQVMNDLFSAGMETSRTTLSWTLLMMIHEPDVAAKVRAQLTETVHPGELVTLDHRPELPY LEAVLFETLRCVSLVPLGTTHVNTT () SEWKVDKYVIPKGAHIIPLIGKMNNDPKVYPEPDKFKPERFLRDGQFHIPDSYMAFGVGQ RLCLGIQLARMQLFLFFANIMNRFEFSLPEGAEMPPLEGFMAATHTPLPYSLCFHKIDN* CYP49A like sequences >CYP49A1 44% to 301A1, BAAB01133495.1 BAAB01150577.1 BAAB01091102.1 BAAB01198981.1 BAAB01133297.1 BAAB01093561.1 possible N-term note: C-term exon on this gene has been changed 7/20/04 because it matches better to the CYP49A1 Apis mellifera sequence. Bmb020819 from Li Bin MIMINLLGAKNSMLSTCPVHIQRARSTHVVDATAFEVSSPVKPWEDVPGPKPLPLLGNTWRFTPYI (1?) GSYSVEHIDRICVSLRAKYGKCVKMAGLLGRPDMLFVFDANEVERVFRGEDAAPHR () PSMPSLNYYKHTLRKDFFSAEENCAGV () HGDSWSAFRTKVSRVALSAGAAAQYTAPVAEVADCFVER () IRKIRDENMETPEDFLNEIHKWSLE () SLGLIALDTRLGCFEACEGSESQRLIDAV KTFFLCVGELELRAPCGGSTPPPCSDERRCFRHYPQV () SVTLRHVDKALEEIKLNGSSKSLLQDLVTAAGARVAAVAALDMFLVGIDT () TSTAVASILYQLSSRPHVQEKIYEEVTKALQGRPMSPGDLNQMPYLKATVKEVLR () MYPVVIGNGRQLTKDTVICGYNIPKG () TQVIFQHYVMGNSEEYFKDASQFRPERWLKRTAQRHHAFASLPFGYGKRMCLGRRFAELEIHTVICK (0) >BAAB01052936.1 possible C-term for this gene LLQKYKLEYHYGDLEPTRSFIARPKRALKLRFIDRI* >CYP49A2 BAAB01014940.1 BAAB01083735.1 51% to CYP49A1 Drosoph. BAAB01056249.1, AADK01003288.1 first exon is a guess MLSGACTAHYTKHIRCVIIVMKYQTTVAAALESFRNF (1) ARCYTVMPGPRPLPILGNSWRFALGW KPWRTKRLDLTLWCLRSLAGAGGAAKVAKLFGHPDLVFPFCAEETARIYRREDAMPHR AAAPCLKHYKQELRKDFFGDEPGLIGI () HGEPWSRFRSKVSKALIAPEAARAAVPELDYVANDFVIR () LEHLLDLNRELPKDFLTELYKWALE () SVGAWALGTRLGCLNDTKTDAKEMIK CIHGFFHSVPELELSAPLWRIYSTPAYKTYIEALDSFRL () LCLKRLTDKGVCAQVAKNCGQKVATILALDLMLVGVDTTAA () AAASSLYLLANVPRAQRALQKELDTNLPKNRILNDKDLDKLPYLKACIKEALR (2?) MKPVILGNGRCIQSDTTISGYKVPKG (0?) THIVFPHYVLSNEERYFPSPHEYVPERWLRENDIAG (gc boundary?) VCRKQKEIGIHPFASLPFGFGRRMCVGKRFAEVELQLLLAR (0?) IFQKYNVLWRHPELTYSVTPTYIPNESLKFTLNKRNE* CYP301A1 sequence >CYP301A1 65% to Drosophila 301A1, 64% to Apis 301A1 BAAB01030444.1 BP117781 BAAB01134599.1 BAAB01155686.1 BAAB01102862.1 BAAB01093671.1 BAAB01132355.1 BAAB01006099.1 MGRALRSFAAYARPIQLQSTRNSSSCPFSKRQRSQIAPTAELNEEIFA NARPYSEVPGPRPIPILGNTWRMVPVIG QFDISEFAKVTKQFLDTYGRIVRLGGLIGRPDLLFVYDADEIER MYRREGPTPFRPAMPCLVKYKSEVRKDFFGELPGVVGV () HGDQWRRFRSKVQRPILQPQTVKKYVAPIELVTEDFIKYMVDARDENGDLPHEFDNDIHRWSLEC () IGRVALDVRLGCLSPQLNSNSEPQRIIDAAKFALRNVAVLELKA 306 307 PYWRYIPTPLWSK YVNNMNFFVE () 368 ICSRYINEALERLKTKKVTSENDLSLLERVLRSEGDPKIATIMALDLILVGIDT 529 () ISMAVCSILYQAATRLEQQDKMAEEIRRVLPDPSKPLSYSDLDKLHYTKAFVREVFR () MYSTVIGNGRTLQDDDVICGYHIPKG () QVVFPTIVTGNMEQFVSDPLEFKPERWLEGGGKLHPFASLPYGFGARICLGRRFADLEIQVLLAK (0) LLSRYRLEYHHEPLDYAVTFMYAPDGPLRLRMIER* CYP302A1 like sequence >CYP302A1 46% to 302A1 Anoph., BAAB01119552.1 BAAB01040509.1 BAAB01022270.1 CK534186 BAAB01132138.1 missing N-term or N-term not identified AADK01003274.1 MFVRLTVKNNIPYRARKCVYRRASENFVGSEHASKVNEQGDNLM 8340 NFEDIPGPRSYPIIGTLHKYLPLI (1) 8411 GDYDAEALDKNAILNWRRYGSLVREKPIVNLVHVYDPDDIEAVFRQDHRYPARRSHTAMNYYRTNKPNVYNTGGL () LRSNGPDWWRLRSIFQKNFTSPQSVKTHVSDTDNIAKEFVEWIKRDKVSSKNDFLTFLNRLNLE () IIGVVAFNERFNSFALSEQDPESRSSKTIAAAFGSNSGVMKLDKGFLWKMFSTPLYKKLVNSQIYLEK () ISTDILIRKINLFESDDSKNDKSLLKTFLQQPQLDHKDIMGMMVDILMAAIDT (0) 463 TAYTTSFVLYHIARNKRCQDEMFEELHTLLPKKDDEITADVLSKASYVRSSIKE 536 SLRLNPVSIGIGRWLQKDIVLKGYSIPKG (0?) VIVTQNMTSSRLPQFIRDPLTFKPERWMRGSPQYETIHPFLSLPFGHGPRSCIARRLAEQNICIILMR () LIREFEIQWAGEELGVKTLLINKPNKPVSLNFIPRSS CYP303A1 like sequence >CYP303A1 45% to CYP303A1 BAAB01045446.1 BAAB01180906.1 BP126135 BAAB01031702.1 Bmb002871 Bmb015732 from Li Bin MWLAALAVLLAVCLYLFLDTLKPRKFPPGPKWTPILGCAKEVYKLREK () TGYLYKAVRELSLTYCKETPVLGLRIGKDRIVMVNSLEANKEMLFNEDIDGRPKGIFYQTRTWGERRGVLLT DGELWKEQRRFLIKHLKEFGFGRSGMGETAKLEAEHIVIDVMHMIGDRGSAVIQMHN FFYVYILNTLWTMMAGNRYNPSDPQMKILQ SMLFDLFAAVDMVGTAFSHFPILSIVAPTLSGYR NFIKTHKRIWKFLREELARHKDSFQPDKEDKDFMDVYIRALREHGEVNTYSEGQ LVAMCMDMFMAGTETTSKSMSFCFSYLVREQEVQRKAQEEIDRVVGKDRVPSVNDRPN (2) MPYNEAIVHECVRHFMGRTFGVPHRALRDTTLAGCHIPE (0) DTMVVSNYTNILLDENYFPEPYSFKPERFLVNGRVSLPDHYFPFGLAKHRCMGDALAKCNIF VFTTTMLQRFSLVPVPGEGLPSLDHMDGATPSAAPFKALVIPRI* CYP305A sequence There is no 305A sequence. CYP305B1 sequence >Bombyx mori CYP305B1 mRNA AB044900 BAAB01125622.1 Bmb009083 Bmb026475 BY931349.1 EST., AADK01021449.1, BAAB01102353.1, BAAB01149133.1 BY922832.1, BP117067 ESTs, BAAB01028853.1, BAAB01141906.1, AADK01007172.1 MLPVLVCIIVIVLICCNVIRSVIKPEKFPPGPIWYPFFGSSSIV QQMTSKHGSQWKALLELSKQWSTQVLGLKLGRELVVVVYGEKNVRQVFSESEFDGRPN SFFYKLRCLGKRLGVTFVDGPLWREHRQFTVKHLKNVGFGKTSMELEIQNELKLLREY INDNKHKPIKVDSMFSSAVMNVLWKYVAGERIREDKLERLLELFYLRSKAFTLTGGLL SQIPWCRFIIPGLSGYKLIVDLNQQISEIIEEAIKKHLNKEVQQNDFIYSFLDEMNEE NKASFTYDQLKTVCLDLIIAGSQTTGNAVKFALLSVLRNKNIQEKIFNEIENTIGDSM PCWADSSKLVYTSAFLLEVMRIHTIAPLAGPRRVLQDTVIDGYVIPKETTVLISLADI HLDPNLWPDPHEIKPERFIDEKGLSKSNEHIYPFGSGRRRCPGDSLARSFVFIIFVGI LQKYRIDCVNGVLPSNEADIGLLAAPKPFVANFVSRE related to BX561870.1 Glossina morsitans (50%) GTRKGITGVDGPLWYEHRHFSMKQLRNVGFGRTPMEKHIERETDDLLAYIEGLNGLPVCP SSFLAHVVINVLWTMVANKHFAYEDKRLEKLLNLLHRRSQAFDMSGGLLSQY PWLRFIAPKKTGYNIICQLNNELHEFFMETIEKTQAHTDARKC CYP306A1 sequence >CYP306A1 mRNA for cytochrome P450 monooxygenase, complete cds. BAAB01049676.1 BAAB01150476.1 BAAB01016115.1 BAAB01136488.1 BAAB01075467.1 ACCESSION AB162964 Niwa,R., Matsuda,T., Yoshiyama,T., Namiki,T., Mita,K., Fujimoto,Y. and Kataoka,H. TITLE CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid biosynthesis in the prothoracic glands of Bombyx and Drosophila JOURNAL J. Biol. Chem. (2004) In press 41% to Drosophila m. 306A1 AV404609 Bombyx mori prothoracic gland cDNA MDLYFIWLVTFVAGFWIFKKIKEWQNLPPGPWGLPIVGYLPFID RYHPHITLTNLSKTYGAIYGLKMGSIYAVVLSDHKLVGDTFSKDSFSGRAPLYLTHGL MNGNGIICAEGGLWRDQRKLITSWLKSFGMSKHSVSREKLEKRIASGVYEILENIEKT SDAALDLPHMLTNSLGNVVNEIIFGFKFPPEDKTWQWFRQIQEEGCHEMGVAGVVNFL PFIRHVSPSTRKTIEVLVRGQAQTHTLYASMIDRRRKMLGLEKPKGAEYAPHENLLKL YPNGHIKCIKYSKVSPNTEHFFDPNTLIPTEGDCILDNFLLEQKKRFESGDPTALYMR DEQLHFLLADMFGAGLDTTSVTLAWFLLYMALFPEEQEEIRKEILSVYPYDDDVDSSR LPLLMAAICETQRIRSIVPVGIPHGCIEDAYLGNYRIPKNAMVIPLQWAIHMDPNVWE EPEKFKPRRFLAQDGSLLKPQEFIPFQTGKRMCPGDELSRMLSCGLVSRLFRKQRIRL ASKIPTAEEMRGTVGVTLAPPPVKYYCEPI CYP307A1 sequence >CYP307A1 51% to 307A1 probable ortholog BAAB01102325.1 BAAB01020228.1 Bmb008079 from Li Bin MSSLIIVLFVFALAVYKLLRRKTVRWVKTNKYGGVETAILRTAPGPVCWPIIGSLHLLGG HESPFQAFTELSKKYGDIFSVKLGSADCVVVNNLSLIREVLNQNGNVVAGRPDFLRFHKL FAGDRNN () SLALCDWSNLQLRRRNLARRHCGPKQHTDSHARIGTVGTFESVELIQTLKGLT SRSDASIDLKPILMKSAMNMFSNYMCSVRFDDEDLEFQKIVDHFDEIFWEINQGYAVDFL PWLAPFYKKHMEKLSNWSQDIRSFILSRIVEQREINLDTEAPEKDFLDGLLRVLHEDPTM DRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPEVGRKIRQEIDAVTRGKRPVGLTDRS HLPYTEATILECLRYASSPIVPHVATENANISGYGIEKGTVVFINNYVLNNSEQYWSEPE KFDPSRFLEKTRVRTRRNSQCDSGLESDSERAPVGKPDVEREMLSVKKNIPHFIPFSIGK RTCIGQTMVTSMSFTMFANIMQSFEVGVENINDLKQKPACVALPKNTYKMHLIPRK CYP314A1 sequence >hypothetical CYP314A1 ortholog from many non-overlapping fragments 49% to 314A1 BP179750 BP179443 BAAB01069738.1 BAAB01063661.1 BAAB01099804.1 BAAB01099804.1 BAAB01122030.1 BAAB01134118.1 MQSTSPPLLDWSCVPTLVLAVIAVVVAVTALLTRTSDAKHSCR LPGPQPLPFLGTRWLFWSRYKMNKLHEAY () ADMFKRYGPVFMETTPGGVAVVSIAERTALEAVLRSPAKKPYRPPTEIVQMYRRSRPDRYASTGLVNE 1435 QGEKWYHLRRNLTTDLTSPHTMQNFLPQLNTISDDFLELLNTSRQSDGTVYAFEQLT 1265 1264 NRMGLE AVCGLMLGSRLGFLERWMSGRAMALAAAVKNHFRAQRDSYYGAPLWK 783 784 FAPTALYKTFVKSEETIHA 840 2337 VPDRIVSELMEEAKSKTTGMAQDEAIQEIFLKILENPALDMRDKKAAIIDFITAGIET 2510 87 LANSLVFLLYLLSGRPDWQRKINSELPPYAMLCSEDLAGAPSVRAAINEAFR 242 243 LLPTAPFLARLLDSPMTIGGHKIPPGTFVLAHTAAACRREENFWRAEEYLPERWIK 410 411 VQEPHAYSLVAPFGRGRRMCPGKRFVELELHLLLAK (0) IMQKWRVEFDGELDIQFDFLLSAKSPVTLRLVEW* CYP315A1 sequence >CYP315A1 mRNA for homolog of shadow, complete cds. ACCESSION AB167737 BAAB01119643.1 Niwa,R., Matsuda,T., Yoshiyama,T., Namiki,T., Mita,K., Fujimoto,Y. and Kataoka,H. TITLE CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid biosynthesis in the prothoracic glands of Bombyx and Drosophila JOURNAL J. Biol. Chem. (2004) In press MHRFPSMSSIRSAVRSRNSNRCSMSTKPHKSLRTIDEMPHKKSL PIIGTKFDLFSAGGGKNLHKYIDMRHKQLGPIFYERLTGKTKLVFISDPTHMKSLFLN LEGKYPAHILPEPWVLYEKLYGSKRGLFFMDGEDWLINRRIMNKHLLREDSDVWLRAP IRTAVFHFICNWKLRAQSGNFSPNLESEFYRFSTDVILAVLQGNSALLKPTPEYEMLL LLFSEAVKKIFSTTTKLYALPVEFCQRWNLKVWRNFKQSVDDSISIAQKIVYEMLHTK DAGDGLVKRLKDENMSDELITRIVADFVIAAGDTTAYTSLWILFLLSNNTEILTEMND NDQYVKNVVKEAMRLYPVAPFLTRILPKQCVLGPYLLEEGTPVIASIYTSGRDEQNFS KADQFLPYRWDRNDQRKKDLVNHVPSATLPFAFGARSCIGKKMAMLQMTELISQIVKN FDLKSMNNSDVDAVTSQVLVPNKDIKVLILPRSISK CYP324A sequence >CYP324A1 45% to 324A1 Trichoplusia ni BAAB01098782.1 BAAB01016062.1 BAAB01088903.1 BAAB01068119.1 BAAB01136435.1 Bmb031911, Bmb031912 from Li Bin MLFIIIFIFILLLLTWWLIRWQQVKSYWAARNVPHEPPHPVLGSLTFLQKENP () SIWLIKLYKKFPFPYIGIWLFWKPALIINSPELARQILTKDADTFRNRFSNAGKSDPVGALNLFMIN () DPVWSSVRRRLTPVFTKLKLQALYPILIRKSNDLKKRIKEDTEKNIKINLR () SLFVDYSTDILGEAAFGVSSNSITTGESAMREVTKDFMKFDWLRGLQWSCIFFFPELADFFR (2) CKLFPKESLEILRKIYRTMVAERSKSQSISGKSKDLLDALMAMKIEAAAENE () VYNEDLLFAQATLFVQAGFETTSSAITFAIYELAYNPEIQ () ERLYREIVEAKQKMEGNELDGVVLSNLQYLNCVIN () ETLRKYPSLGWLDRVSSQSYKVDDTLTVPAGTAVY VNVAGIQSDPQLFPKPEEFIPERFNTDNNNIKPFTFIPFGEGPRQCI () GIRFGYQAIQFGLSAIILNFKLRPIEGSPLPNNCHIESKGFVYTADHPLHIQFVPRN* CYP341 sequences, weakly similar to CYP325 These sequences are closely related and are weakly similar to CYP325 There appear to be six genes. 5 exon 1 seqs., 6 exon 2 seqs., 6 exon 3 seqs., 6 exon 4 sequences, 7 exon 5 seqs., 6 exon 6 seqs., 5 exon 7 seqs., 6 exon 8 seqs., 6 exon 9 seqs. >CYP341A1 9 exons 39% to 4C3 BAAB01068196.1 BAAB01181661.1 BAAB01053162.1 BAAB01098630.1 BAAB01068157.1 BAAB01166031.1 BAAB01162916.1 Bmb018467 from Li Bin, AADK01007855.1 MIVILLIVLVLGWFSVFRYRRRNMYKLAAAIPDVDKHIPLLGIAHKFTGNTE () VLSNPVDSEVVLKTCLEKDDLHRFIRAIIGYGGIFAP () VSIWRRRRKIMVPAFSPRIVQSFVGIISEQSEKLASNLGKRVGKGMFSSWPFLSAYTLDSVC () ETALGVKINAQGDKDSSFLKSMNRILNIVCMRIFHLWLQPVWLFKLFPVFNEHQSCIEMLHDFVDK (0) VIQNKREEIKRENNSKTEVDYEY (1) NLGSYKCKTFLDLLITLSGAEKGYTNIELREEVLTLTVAGTDTSAVAIGFTLELLSKYPEIQEKVYKE () LREVFCDSERPLIKEDLEKMKYLERVVKESLRLFPPVPFIIRKVLEDMTL (1) PSGSVLPAGSGIVVSIWGIHRDPKYWGPEAEHFDPDRFLPERFNVEHPCCYLPFSSGPRNCL (1) 1097 GYQYAMISIKTSLSAILRRYKVVGEPEKGPVPRIRVKLDIMMKSVEGCQVALERRPTK* 921 >CYP341A2 Papilio xuthus MFLCLLCLSVVLGMVLFKLKRRRLYRLASKIPGSDDELPFIGLA HKFTGTTEDILNSLQKYSYEAMKNNGILRGWLGHILYFIVVDPVDVEVILKTSLEKDD LHRFIRNVIGNGLIFAPVSIWRRRRKITVPAFSPKIVDTFMEVFAEQSEKLVSVLAAC AGNGYIAMEPYLCRYTLDSVCETTMGITTNAQNNPNAPYLKALKNILNLVCERIFHLW LQPDWLYKFFSQSKSHQKYTKEMQGFVDEVIQNKRREIKKEKDLKSEVDRNFGLSNYK TQSFLDLLIEFSGGENGYTDLELREEILTLTIAGTDTTGISIGYTLKLLAMYPKVQDK LYQELLDVFGTSDRRIVKEDLSKLKYLERIVKESLRLYPPGPFIIRKVLEDISLPSGR VFPAGSGAAVSIWGLHRDPKYWGPDAEVFDPDRFLPERFNLKHACSYIPFSSGPRNCI GYQYALMSMKTVLSAIVRRYKIMGEESGPVPHIKSKIDIMMKAVDDYKICLEKRFK >CYP341A3 AADK01027984.1 96% to 341A1 exons 1,2 MIVILLIVLVLGWFSVFRYRRRNMYELAAAIPDVDEHIPLLGIAHKFTGNTE 2243 4155 PRDLELVLKTCLEK 4196 >CYP341A3 AADK01029147.1, BAAB01096639 exons 4,5 1917 ETAMGVKVNAQGDKDSNFLISMNRILNIVCMRIFHLWLQPAWLFKLFPVFHEHQKCKKLLHDFVDE 1720 1030 AIQKKREEIGTENNSAIEVDYKY (1) 962 >CYP341A3 BAAB01031047.1 43% to 4G15 342-572 45% to 4AU1, exons 6-9 AADK01017121.1 4094 LGSYKSKTFLDLLITLSGAEKGYTNIELREEVLTLTVAGTDTSAVAIGFTLELLSKYPEIQEKVYKE 3894 3561 LCEVFGDSERPLVKEDLEKMKYLERVVKESLRLFPPAPFIIRKVLEDITL 3412 (1) 2636 PSGVMVSIWGIHRDPKYWGPEAEHFDPDRFLPERFNVEHPCCYMPFSSGPRNCV 2451 2226 GYQYAMISIKTSLSAILRRYKVVGEPEKGPVPQIRVKLDIMMKSVNGCQVALEKRPTK* 2050 >CYP341A4 35% to 4G1 BAAB01061620.1 (C-term), BAAB01046550.1 BAAB01151967 BAAB01098630, BAAB01016786.1 exon 3 BAAB01023249.1 BAAB01137180.1 BAAB01039204.1 BAAB01138999 42% TO 4G15 341-572 45% to 4AU1 AADK01003016.1 whole gene plus adjacent gene 88% to 341A1 8810 MIVILLIVLVLGWFSVFRYRRRNMYKLAAAIPDVDERIPLLGIAHKFTGNTE 8965 (1) 11577 ALLNPVDMEVVLKTCLEKDDLHRFMRVVIGYGGIFAP 11687 (1) 14661 VSIWRRRRKIMVPAFSPKIVQSFVGIISEQSEKLASNLGKCVGTGKFSSWPFLNAYTLDSIC 14846 (1) 15391 ETAMGVKVNAQGDNDSIFLKSLNRMLNIVCMRIFHLWLQPTWLFKLFPVFHEHQKGKKLLYDFVDE 15588(0) 16204 AIQKKREEIRTENNSGTKVDYKY (1) 17580 DLGSYKSKTFLDLLITLSGAEKGYTNIELREEVLTLTVAGTDTSAVTIGFTLELLSKYPEIQEKVYKE (2) 18316 LCAVFGDSERPLVKEDLEKMKYLERVVKESLRLFPPVPFIIRKVLEDITL (1) 19211 PSGNILPAGSGVVVSIWGIHRDPKYWGPEAEYFDPDRFLPERFNVEHPCCYMPFSSGPRNCL (1) 19622 GYQYAMISIKTSLSAILRRYKVVGEPEKGPVPQIRVKLDIMMKSVNGCQVALERRPTK* 19798 >CYP341A5 BAAB01076430.1 Length = 917 exon 4, AADK01008138.1 only one exon in 13kb 150 ETAMGVNINAQAKADSEFLKSLNRLLNVICERIFHLWLHPDWLFKQLPVYDEHQKCIKVLHEFIDQ 347 (0) >CYP341A5 AADK01003016.1 exon 5,6,7,8,9 BAAB01039204.1 BAAB01036273.1 BAAB01189227.1 BAAB01150672.1 BAAB01106539 note: mariner transposase is upstream Bmb022600 from Li Bin 570 VIQNKREEFQIEKISKIEVDTQY 638 1347 DLGLYKRKTFLDLLITFSGDEKGYTNVELREEMLTLTVAGTDTSAVAIGFTLELLAKYPKIQDKVYQE 1550 2502 LYEIFDGSERALVKEDLEKMEYLDRVVKESLRLFPPVPFIIRKVLEDTRL 2651 3624 PSGNVLPAGSGIMVSIWGIHRDPKYWGPEAEHFDPDRFLPERFNLEHPCCYMPFSSGPRNCL 3809 4037 GYQYAMISIKTSLSAILRRYKVVGEPEKGPVPQIRVKLDIMMKSVNGCQVALERRPTK* 4213 >CYP341A6 AADK01011365.1, 95% to BAAB01046229.1, same as BAAB01090513 same as BAAB01110300.1, Bmb029009 from Li Bin AADK01018246.1 exons 2-7 AADK01015317.1 same as AADK01032246 at aa level 97% at nucl. Level MIALLLILVGLGWVLVFRYRRRNMYKLAAAIPTPDETNLLVGVAHKMMGNTE 2420 VSSNPFDLEVILKTCLEKDDSHRFFRPGIGNGGIFAP 2530 3077 VSIWRRRRKIMVPAFSPKIVHSFVGIISEQSEKLVSSLSKCVGKGMFSSWPFLSAYTLDSVC 3262 3934 ETAMGVNINAQAKAESELLKSMNRFLNVICERMFHVWLHPDWLFKQFPVFNEHQKCIKVWHEFIDQ 4131 6718 VIQNKREEFQMEKISKDLEVDTHY 6789 7230 DLGSHKSKTFLDLLITFSGDEKGYTNVELREEMLTLTVAGTDTSAVGIGFTLELLAKYPK IQE 7418 8335 LYGIFDGSERALVKEDLEKMKYLERVVKESLRLFPPVPFIIRKVLEDTRL 8484 >CYP341A6 BAAB01059505.1 exons 8,9 BAAB01018260.1 exact overlap 15 aa 44% to CYP325F 395-482 2796 SGNVLPAGSGIFVSIWGIHRDPKYWGPEAEHFDPDRFLPERFNVEHPCCYMPFSSGPRNCL 2978 1565 GYQYAMISMKTSLSAILRRYKVVGEPEKGPVPRIRVKLDIMMKSVDGCQVALERRPTKLC* 1383 >CYP341A6? 3 aa diffs AADK01021477.1 = BAAB01167086.1 exons 8,9 only 2 exons in 6kb 4834 ASGNVLPAGSGIVVSIWGIHRDPKYWGPEAEHFDPDRFLPERFNVEHPCCYMPFSSGPRNCL (1) 4649 4404 GYQYAMISMKASLSAILRRYKVVGEPEKGPVPRIRVKVDIMMKSVDGCQVALERRPTKL * 4225 >CYP341A7 AADK01032246.1 = BAAB01046229.1 exons 1-6, BAAB01077822.1 Note exons 1,5,6 same as AADK01011365, this seq might be a hybrid If 5 and 6 are removed ths could join with AADK01003016.1 2328 MIALLLILVGLGWVLVFRYRRRNMYKLAAAIPTPDETNLLVGVAHKMMGNTE 2483 1432 VSSNPFDLEVILKTCLEKDDLHRFFRPAIGYGGIFAP 1542 1804 VSIWRRRRKIMVPAFSPKIVHSFVGIISEQSEKLVSSLSKCVGKGMFGSWPFLSAYTLDSVC 1989 2671 ETAMGVNINAQAKADSEFLKSLNRLLNVICERIFHVWLHPDWLFKQFPVFNEHQKCIRVLHEFIDQ (0) 2868 VIQNKREEFQMEKISKDLEVDTHY (1) DLGSHKSKTFLDLLITFSGDEKGYTNVELREEMLTLTVAGTDTSAVGIGFTLELLAKYPKIQENIFQE &&&&&&&&&&&&&&&&&&&&&& >CYP341B1 AADK01018717.1 exons 1,2, 43% to AADK01032246 BAAB01172821.1, BAAB01064393.1 4511 MLVQLILCIFVALWLLSQRYKKKEMMKVWEQLKNDYTALPLIGHAYMFFGSQE 4353 2836 VISEPVMAEYVLKTCLEKDDILKCSRFLVGNGSVFAP 2726 >CYP341B1 BAAB01092271.1 Length = 1739 25% to 4S4 ETAM exon 4 GC boundary 708 ETTLGVKVNAQGNSEQPFLRAFEIICRLDSSRFCQPWLHNDTVYKMMPQYQQHKDSKDFLCNFIDQ 905 (0) These two sequences probably join with one more exon between >CYP341B1 44% TO 4M8 BAAB01210990.1 47% to 4H23 41% to 4AA1 anoph DAHRNGLKSFLELLIESSGGNKGYTDLELQEETLVLVLAGTDTSAVGVAFTSVMLSRHQDVQEKVYEE () LKEVFGDSDRPIVADDLPKLKYLEAVIKETMRLYPPVPLIVR KVDKDVTLPTGLTLVKNCGIVINIWAVHRNPLYWGDDADIFRPERFIDTPIKHPAAFMAFSHGPRACI GYQYATMSMKTATANLLRHFRLRPAEPTDPTYKHEKNKPLRVKFDVMMKDMDNFTVQLEPRYK* >CYP341B1 joined sequences BAAB01092271.1 BAAB01210990.1 Bmb003145 from Li Bin AADK01012599.1, BAAB01092272 2366 (1) VSIWRPRRKILAPTFSPKNLTHFVDIFSKQSSYMVKYLGKAAKTGNFSIWKYINTYSMDSIC 2184 708 ETTLGVKVNAQGNSEQPFLRAFEIICRLDSSRFCQPWLHNDTVYKMMPQYQQHKDSKDFLCNFIDQ 905 (0) VIKSKRNSLEEQKDSTEADQ(1) NAHRNGLKSFLELLIESSGGNKGYTDLELQEETLVLVLAGTDTSAVGVAFTSVMLSRHQDVQEKVYEE () LKEVFGDSDRPIVADDLPKLKYLEAVIKETMRLYPPVPLIVR KVDKDVTLPTGLTLVKNCGIVINIWAVHRNPLYWGDDADIFRPERFIDTPIKHPAAFMAFSHGPRACI GYQYATMSMKTATANLLRHFRLRPAEPTDPTYKHEKNKPLRVKFDVMMKDMDNFTVQLEPRYK* &&&&&&&&&&&&&&&&&&&&&& >CYP341C1 BAAB01149680.1 36% TO 4H18 AA 111-182 C-HELIX exon 3 594 VNIWHRRRKLLNPHFGTKNQNNFMETFIKQSAVLVNNLRKEADNGTFSVWDYLTAYTLDSVC 409 >CYP341C1 44% to 4d 299-345 I-helix 77% to 4H8 61% to gene 1 above BAAB01135732.1, AADK01005588.1 EATLGVQMNSQAHSNLEFLRSFDVCSSLGAARICQPWLHSDIIYHRLQRYKTYQKNTEYVLDFVKQVSIF tgt (1) 592 PTSDNGMKTVLELLILNKTFNDVELQEEAFVMIIAGTDTSAIGISFTLLMLARYPDVQEKVYQE 783 IQELFGDSERPPEVEDIHRLLYLDAVIKEAMRLYPPAPVIIRKVERETKL (1) cgt &&&&&&&&&&&&&&&&&&&&&& >55% to CYP341B1 BAAB01045792.1 45% to 325J 66% to BAAB01210990.1, AADK01018755.1 (1) PSGLILPRDIGILIPIWSVNRNPKYWGDDADVFRPERFLDGTKKHPTAFMTFSQGPRACL GFKFAMNSAKAALASILRHYRIKPPSELTSMSPGQYPPIRVKFALMTRDVDNFRIQLESRS* >seq not assigned AADK01004743.1 one aa diff to BAAB01133870 exon 5, only one exon in 17kb 10917 AIQNKRQSIKSTNNSYYRVFNLY 10849 >CYP341-un1 pseudogene fragment 42% TO 313A4 aa 398-442 perf to heme BAAB01044466.1, AADK01012171.1 1181 VPRGTVCAVSAMVMGRARRLWGPDAAEYRPERWLAPPHAQPAAFLAFSYGRRACI 1017 () CYP332A sequence >64% to CYP332A1, 37% to 324A1, 32% to 6G and 6d CK502566 Bombyx mori cDNA corrected C-term CK518690 Bombyx mori cDNA CK526599 Bombyx mori cDNA CK522682 Bombyx mori cDNA BAAB01119140.1 BAAB01018054.1 BAAB01100160.1 BAAB01098663.1 BAAB01157576.1 MDVSGPLQLFLIFIIFCLTA IYLLFNRNYQYWEKRGVPYEKPFFLFGSLSFILRKSFWDYFYELSKRHTGDYVGIFLGFK PTLMVQTPEIARRILVKDNAHFNNRYCYSSYGVDPLGSLNLFTVK () NPKWSNIRHELSPMFTSLRLKTICELMNVNAKELVLKIQRDYIDNNEDVNLK () ELFSMYTSDTVGYTVFGLRVSALNDPSSPLWFITNHMVKWDFWRGFEFTAIFFVPALARFLR () LKFFSQPATEYIMRLFRTVVDERKKTNQNTDKDLVNHLLKLKENLKLGADI () KLADEIMMAQAAVFILGSIETSSSTLSYCLHELAYHPEEQQ () KLFEEVDDAIKETGKEILDYENLQELKYLSACILETLRKYPPVPHIDRVC NKTYKLNDELTIEEDIPVFVNVLAIHRNEKYYPEPDQWRPERMIGVTDNDNLQYTFLPFGDGPRFCI () GKRYGLLQMRAAIAQMIHKYKFEAAEPHSTPSDPYSVILSPKSGGRIKFVPR* CYP337 new family sequences >CYP337A1 60% to 337A2 29% TO 6A21 30% to 6P3 36% to CYP321A1 BAAB01181176.1 BAAB01007828.1 BAAB01049389.1 Bmb030264 from Li Bin MLLLLLISFTLLLIFFWKQNNYWKSRNVKQVTGTLFKFTFGSRSLPEYYKEIYDKHNESQ IGIYLGRRPAIILKDLRDIQAVLAGDFQSFHSRGIILSEKETLADSILFIDDLPRWKILR QKLSPAFSSLRLKTMFEGIERSARDFVEFIENSGNDQDLEEMPFNAIYKYTTGSIGAAVF GVDVDQNTLDTPALNITRKALEPTLKSIMTFFLAGTFPRLIKWLDMMNFDNYETSFIDAV KKVLENRRAGEKQYDFIDVCLELQNHEVLRDLVTGYEIVPTDELLAAQAFFFFVAGADTT ANVMHFTLLELSSNPSVLKKLHAEIDEVFQDGKKTLNFEDMDKFKYLEMVVNETMRKYPP IGLLQRICTKETNLPSNNLRISKDTIAVVPVLALHRDERFYPKSDAFDPQRFAPENFNEI NKFSFLPFGEGNRVCI () GAKFARLQLRAGLAWLLRKYTLVPQDYKPVKFERSPFAVRDTKAKYRLINRTN >CYP337A2 BAAB01100580.1 BAAB01137171.1 new family 60% to 337A1 31% TO CYP6as 35% to CYP6AB1 BP123442 EST 37% to CYP321A1 MLPVLVIVSLVAILILYWQSSNYWKKRNVREVNGTVLKFTFGNCSLPEYYKQIYDKYNEN QIGFHLGASPALVLRDLQDVQAVLASNFQSFYRRGFAVNDADVLGGNMLFLDDLPRWKIL RQKLSPAFSSLRLKAMYEAIEKTARDFTDYIATDERAIKEPFDAVLKYTTASIGVAVFGL DEKGESLIDLPLSHVAGNALKPSLKANIVFFIGSTFPRLFKWLNMTFFGEYEDVFIGAVK KVLKNRRKLDKRLDIVDVYLDMQSSGRLRDVVTGFEMEPTDEVIAAQSFFFYVAGADTTA NAIHFILLELSANPHVLNKLHAEIDTVLPKGTEVLTFEDIDRLTYMDMVISEAMRKYPPI GFIQRLCTKDAILPSNNLRISKDTVTVVPILAIHRDERFYPNPDVFDPERFTPEKIKERN KFSYLAFGEGNRICIGARFSRLQVKACITWLLRKYTLKPQEYKPERFERSAFSLRDTKSK YEFIRRTN CYP338 new family sequence >CYP338A1 new family LIKE CYP6 BAAB01074380.1 (one exon covers first 408 aa) C-term lies beyond a repeat sequence. No ESTs cover it AADK01008949.1 MFFESFLLNLSVLIVLIVALVFDYVTKFFSYWYVRHVPYKTPIPFFGSDYHRVLGLTNST DEVVKLYNEHPGDKFVGRLKNRIPDLIVKDPDAIKRMLSTDFAYFHSRGLGLDKSRDVCI RNNLFYADAEKWTLLRQGLEAVLNGLCREFDIHACLSEANGDTNVQQLLSVVLDSVFDNL LLGDEGTSIKELRTTLQKRSMIVKLKSYLKNIFPSIYVTFGLSTLPNNVLKNTRKYMESS KLQRLIDDSGYMHQVSLKDKHVYAFENEFASSTLAL FVTEGYIPCLYTLTALFYELAVNP QIQEKARNSIEKDKGVNYLDAIIKETMRLHPSHSIISRQCVKMYQYPDSNLTIDRNVTIN VPVEAIHKDKEHYENPEVFNPERFFDDHGPTKHSYSYLPFGAGPRKCI CYP339 new family sequence in the mito clan >CYP339A1 new family in mito clan, CK534983 CK537464 CK535691 BAAB01021114.1 31% to 301A1 anoph. BAAB01141557 BAAB01170021.1 BAAB01154229 note: C-terminal exon was changed 7/20/04. This is still a guess. (2 agt)NGEEWSRQRSIIYTPLHNAVTYHIQGIDDICEYFSQKIYNMRNHQDEIPKDLYKDLHKWAFDCL (1) PGLQESNSYKDLHKWALDCL GLILFSKKFSMLDTDLVYSQCDMSWMYHSLEKATEAVIKCESGLQWWKILSTPAWYSWVKYCDSWD () SLIGKYVLEAEQAISYKAKEIEEQY PNSNIWINARLLGQEKMNPEDIATVIMDMWLMGVNT ITSSTSFLLYYLAKYQKAQKILYKEIQENFPEQKIMDLTKIREQTPYLQACIKETLR () LTPPIPVLTRILPKNITLDKYN () IPRGTLIIMSTQDASLKESNYDDANTFCPERWLKSDSNEYHLFASIPFGYGARKC LGQNIAETMMSLLTVK (0?) >BAAB01062474.1 Length = 869 C-term exon for CYP49/301 like gene 217 MIQAYKIEYRREPLEYHIHPMYTPNGPIRLRLVER 321 CYP340 new family only 30-31% identical to CYP4s or CYP325s There are at least 8 genes in the following set. Most of the individual exons do not exist on overlapping contigs so they cannot be joined in a single complete gene 5 exon 1 sequences, 5 exon 2 sequences, 7 exon 3 sequences, 8 exon 4 sequences 8 exon 5 sequences, 9 exon 6 sequences, 13 exon 7 sequences 8 exon 8 sequences, 9 exon 9 sequences, 5 exon 10 sequences This first gene is complete >CYP340A1 old CYP340Aaa CYPnew1 new family BAAB01050176.1 BAAB01056719.1 revised to include exon 2 BAAB01160534.1 (exons 3,4,5) BAAB01199634.1 exon 3 BAAB01056719.1 exon 3 BAAB01196580.1 exon 6 BAAB01158445.1 exon 6 BAAB01006148.1 exon 7 with one stop codon BAAB01212205.1 exon 8 BAAB01008628.1 exon 8 BAAB01212925.1 exon 9 BAAB01103225.1 exon 10 BAAB01050816.1 exon 9 1 aa diff BAAB01009268.1 exon 10 1 aa diff and a frameshift BP124291 MFIPIIVVVVCVLLLFYSIAERHSNVPLCDNYLPVIGHTHMIIGG SGLLQTVKYACEETNKKGGVAILKLGLSNYY VITDPEDNLTVANGTLQKHFVYQFASNWLGDGLITSS GETWKRHRKLLNPAFSQQMLNIYTVVFNRKSRNLISAIEIQMKSGPVLIDTVFREMALNTLL STAFGIEEEDSDFNKKYIHAVDVILALLTRRFQNPLLHYPFFYKLSALKKKEEEVIETILTASKK IIKNKREALNKERSNENGYAT ERKFKSMLELLLKDSDGDALTDEEIRDEVDTLILAGSDTSSQLTLVVVMVLGSYPEIQDKVYQE VASVCGVSDTDVEKHQHPRLVYTEAVLKETLRLYPTVAVVLRKPENEIKL KNYTIPANSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPGNPNAFAGFSVGKRNCI GKTYALISTKIILAHLVRRYKVTADISKIEFKMDVIMTPSDNCYVDFELRK >CYP340A1-de9b BAAB01213048.1 Length = 2727 new exon 9 94% to CYPnew1bb 750 NYTIPSDSNCVLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCI 926 >AADK01017983.1 nearly identical to BAAB01213048, one frameshift and 1 aa diff 2 aa diffs to CYP340A1-de9b 231 NYTIPSDSNCVLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFT 386 388 VGKRHCI (1) >CYP340A2 AADK01003526.1 identical to BAAB01106541.1 (2 genes) nearly identical to BAAB01003905.1 (3 diffs in N-term) identical to CYPnew1dd 78% to 340Aaa, 92% to 340Acc, 66% to 340Abb complete old CYPnew1dd 91% to CYPnew1cc BAAB01128878.1 exon 7 BAAB01171305.1 Length = 1430 BAAB01040719. Length = 645 exon 3 BAAB01163949.1 Length = 1132 exons 3,4,5 BAAB01116297 BAAB01160956 64% to 340A3, 78% to 340A1 1679 MFILIVLVVVCVVLLFYSIKKSNSNVPLCDNYLPVIGHTHMLIGGGK (1) 1545 490 KLLRTVKYACEEANKKGGVVILQLGLENYY (1) 401 VITDPEDNLTIANGALQKHSFYQFASNWLGDGLVTSA GETWKRHRKLLNPAFSQQMLNIYTVVFNQESKNLISAIEIQMKSGPVLITAALKEMALKTLL STAFGIEVEECDFNQKYMHAVDEVMAVLTRRIQNILLHNSFVYKLSALKKKEDELIETITTMSNK VINSKRRALKNKQESHENGCAS 120 EKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGSDTSSQIMTVVVMLLGSYPEIQDKVYQE 311 IKSVCGDSDADVDKLQHPR 8576 8575 LVYTEAVLKETLRLYPITPVVLRKTENEIKL 8483 7374 SYTIPANSNCMLGIYGLNRHPVWGPDAHTFRPERWLELGGVPDDPNAFAGFSVGKRNCI 7198 6278 GKTYALISMKTTLVHLLRRYKVTADISKIEFKLDALMVPSDNCYAKFESRK* 6123 >CYP340A3 old CYP340Abb CK503564 CK511251 CK504721 BAAB01089735.1 new family CYP4 like BAAB01006192.1 BAAB01077706.1 BAAB01092224.1 67% to CYPnew1 AADK01020942.1 complete 3080 MLIPVFLIILCVILYYFYWRDKSINNVPLCDKYLPIIGHTHLFIGNTK (1) 3223 3906 ILRTVKSICEDTNDKGGVTVARLALQDYY 3992 VITDPVDNLKIANGTFLKHFAYRFTSHWLGDGLITSS (1) GETWKRHRKLLNPAFNQQILNSFIGVFNDESRKLVSEIGNEMAKGPVEVTTPFRQMAFRLLF () LTAFGIPVEDSDFNQKYIHSVDKLLSMLIYRFQNVLLHNSFIYKISGLKKKEEQMVETVHAMSNM (0) IIKRKREASKNKSPTDEHCYDT (1) TAHRYKSILDLLLKGLDGDALTDKEIRDEVDTIIVAGYDTSSWVLTLVMMALGSYPEIQNKVYQE () VSSMFGDSEADVDKSHYPGLVYVEAVLKETLRLYPIVPIALRQTESDIELK () NYTIPADSNCVLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRTCI (1?) GKVYALMSMKTTLVHLIRRYKVTADISKVEFKMDVLMTPVNNCNVKFELRK* (-) strand second gene on AADK01020942.1, 2 aa diffs to CYP340A2 1237 MFILIVLVVVCVVLLFYSIKKSNSSVPLCDNYLPVIGHTHMLIGDGK (1) 1106 >CYP340A4 old CYP340Acc CYPnew1cc BAAB01206095.1 BAAB01104811.1 BAAB01080812.1 BAAB01021854.1 91% to CYP340A2 AADK01031494.1 identical to exon 9 adds exon 10 VITDPEDNLTVANGELQKHYFYQFTSNWVGDGLVTSA (1) GETWKRHRKLLNPAFSQQMLNIYTAVFNRESRNLISAIEIQMKSGPVLITAAFKEMALKTLL (1) STAFGIEEEECDFNQKYMHAVDELMAVLTRRLQNILLHNSFIYKLSALKKKEDELIETIMAMSNK (0?) AINSKRRALKNKQESHENGCAS (1) EKKTQSLSDLLLKGLDDEAFTDKEIRNEVDTFIAAGSHTSSQLMTVVVMVLGSYPEIQDKVYQE () IKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPIAPVVLRKTENEIKLK NYTIPANSNCLLGIYGLNRHPVWGPDAHTFRPERWLEPGGVPDDPNAFAGFSVGKRNCI 2581 GKTYALISMKTTLVHLVRRYKVTADISKIEFKMDVIMVPSDNCYVKFESRK* 2426 &&&&&&&&&&&&&&&&&&& >CYP340A5P AADK01040486.1 5 aa diffs to CYP340A1 more seq is known, but confidential 1341 VASVCGVSDDDVEKHHHPRLVYTEAVLKETLRLYPTIPLVLRKPENEIKL 1490 &&&&&&&&&&&&&&&&&&& >BAAB01190249.1 exon 6 85% to CYP340A1 144 IIKNKRESLNKERSNENSYTT 206 >BAAB01092011.1 Length = 2603 3 aa diffs with CYP340A1 1939 MFIPIILVVVCVLLLFYSIAERHSNVPLCNNYLPVIGHTHLIIGG 2073 >BAAB01106113.1 Length = 2553 90% to BAAB01003905.1, 1 aa diff to CYP340A2 2098 MFILIVLVVVCVVLLFYSIKKSNSSVPLCDNYLPVIGHTHMLIG 2229 CYP340A3 facing away from each other 60% to BAAB01003905.1 255 MLIPVFLIILCVILYYFYWRDKSINNVPLCDKYLPIIGHTHLFIG 121 &&&&&&&&&&&&&&&&&&&&&&&& >BAAB01199634.1 Length = 696 exon 2, 2 aa diffs to CYP340A1 same? 25 SGLLQTVKYACEESNKKGGVAILRLGLSNYY 117 &&&&&&&&&&&&&&&&&&&&&&&& >BAAB01023413.1 Length = 2453 exon 2, 66% to BAAB01003905.1 this seq not assigned 1235 SELLRSVKYICGETNKKGGVARCKLGLDYY 1146 &&&&&&&&&&&&&&&&& >BAAB01038139.1 Length = 841 exon 4 new 2 aa diffs to CYP340A1 118 GETWKRHRKLLNPAFSQQMLNIYTAVFNRKSRNLISAIEIEMKSGPVLIDTVFREMA 288 &&&&&&&&&&&&&&&&&&&& >CYP340A6 BAAB01162196.1 Length = 1626 exons 3,4 1 aa diff to Bmb020206 Bmb020206 36% to 313B1 80-182 BAAB01162196.1 exons 3,4 1 aa diff to BAAB01162196.1 all on AADK01002164.1 single gene Bmb020204 33% to 312A1 205-384 90% to Bmb035473 BAAB01073561.1 BAAB01209311 4 aa diffs to Bmb037924 95% to CYPnew1dd 1401 VITDPEDNLTVANGALQKHFFYQFASNWLGDGLVTSS 1291 (1) 1 aa diff to 340A6 5391 VITDPEDNLTVANGALHKHFFYQFASNWLGDGLVTSS 5281 CYP340A6 1016 GETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFKEMALKALL 831 CYP340A6 5006 GETWKRHRKLLNPAFSQQMLNIYTVVFNRESRNLISAIEIQMKSGPVLISAAFKEMALKALL 4821 CYP340A6 ATAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNK ()CYP340A6 2997 ATAFGIEVEECDFNQKYMHAVDEVMAVLTRRFQNILLHNSFVYKLSALKKKEDELIETITTMSNK 2803 340A6 1436 VINSKRRALKNKQESHENGCAS 1371 CYP340A6 VINSKRRALKNKQESHENGCAS ()CYP340A6 EKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGYDTSSQIMTVVVMLLGSYREIQDKVYQE () 2 aa diffs to 340A6 514 TEKKTQSMSDLLLKGLDDEAFTDKEIRNEVDTLIFTGYDTSSQIMTVVVMLLGSYREIQDKVYQE 320 2 aa diffs to 340A6 IKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITP CYP340A6 276 IKSVCGDSDADVDKLQHPRLVYTEAVLKETLRLYPITPVVLRKTENEI 103 CYP340A6 &&&&&&&&&&&&&&&&&&&& >CYP340B1 C-helix 45% to CYPnew2aa BAAB01186081.1 VPLWKQQRKALNPAFKQQILNNFMDIFNNQGRRLIMQLAAHGPGSFDHHHPILINNLESSL 32% to 4C3 aa 307-370 49% to CYPnew2aa I-helix exon BAAB01091571.1 SEETISLLDFILDQDKSKQFLTDEEIREQIDIFLIASFDTSATALIYLLTVVGSYPEVQQKIYDE >CYP340B1 AADK01006724.1 larger seq identical to BAAB01024995.1 exon 9 (-) strand 13326 NVGKLKETNIFMFRILAEVGDNKDVTKDVLPKLVYLEAVIKETLRMYSVVPAIARKTDIDLKLSK (2?) 13132 11570 KNYTIPKGSSIGIMLGTLHQHPQWGPDAHQFRPERWFTENLNVFAPFSMGKRNCI (1) 11409 10588 GKVYAMMSMKVLLVHVFRHYKVTGDISNTEHRLGVLLKPATGHHIKLDKRNKT* 10427 &&&&&&&&&&&&&&&&&&&&&&&&&&& >CYP340C1 BAAB01092938.1 exon 5 Length = 2807 a related ETAM exon 1613 ETALGIKMEDHSAVNQQYEQALHDIFAVLTERFQKFWLHYDFVYNRTKLKEREDQIIKVL 1792 1793 HNMSNTV 1813 >CYP340C1 BAAB01203952.1 Length = 3702 new exon 8 52% to CK533198 2542 VRRVLGDAERDVTKEDYLRLEYLEAVLKESMRMYPVAPVIARYSDAEVKL 2691 >CYP340C1 AADK01006724.1 second exon 9 on same contig (+) strand identical to exon 10 BAAB01125095.1 identical to exon 8 BAAB01203952.1 3243 (0) CGVSCPHRVRRVLGDAERDVTKEDYLRLEYLEAVLKESMRMYPVAPVIARYSDAEVKL(1?) 3392 4640 KNYTAPAGSGFILLLWGVHQHRIWGADADQFRPERWLEAATLPDPSFFAGFSTGRRSCI (1) 4816 7545 GKVYAMMSMKTTLSFLLRRYRVSSDVTDLEFKLEAILRPHRGHYIAIERRSKDDK* 7712 &&&&&&&&&&&&&&&&&&&&&&&&&&& >CYP340D1 CYPnew2aa 46% to CYPnew1bb BAAB01026721.1 (1 aa diff) BAAB01035425.1 Length = 1039 BAAB01188536 BAAB01172813 Identical to AADK01004833.1 (adds exon 1) Bmb018392 from Li Bin 9506 MIILTVSLVIIIAVLGSWMLFYRHYKDSPPFHKGLLPIIGHSYLFMGDTT (1) 9360 SIWRNLKNLAQDCTDKGGVLQIIMGFKRHY IITDPKDALTVANACLQKHFVYSFGSRWLGNGLITGS (1) GEIWKRHR KLLSPSNSPQILNTYLGIFNENSRQLVTDLAPMVGEGLKDLSFHIRKMAMNTIF () RTAFGVYTNEDENFTKAYMSAVDEILTIITKRFTRVWLQIDFIYNLTSIKKREDELIRIVNEMSNK () IIARKRSELASGVAAANET DNKYQGLLDLMLKLAKEDALTDQEIREEVDTAIMAGFDTSSWILVYVLVKLGSFPEVQDRAYNE () 2658 IMDVFGDSDRDLEKEDLSKLVYTEAVLKETMRLYTMGPVSLRHIEEDVKL 2807 >CYP340D1 AADK01018708.1 same as BAAB01096550.1 runs off the end (1) kNFTLKAGTDCSISLFGINRHTVWGEDVNEF 6993 KPERWLDPQKIPDNAFAAFSIGKRSCT (1) 6346 GRAYALTLMKINLAHLLRKYKISGDVSKLDFKFNFIIKPISGSDIGLEYRK* 6191 &&&&&&&&&&&&&&&&&&&&&&&&&&& >CYP340E1 AADK01004833 second gene upstream of new2aa = CK533198 BAAB01132907.1 CK533198 rswgb0_001141.y1 BAAB01126021.1 BAAB01203780.1 BAAB01034164.1 exon 10 overlaps EST seq., 45% to CYPnew1bb 17347 VITHPETAVTVADSTTSKHYIYSFFRRWLREGLLTSS (1)17237 16897 GGVWKRHRKLVSPSFNLRVLYSFMGVFNSGSKKLINHFRDEMNKGPLNVLPLIKVVSLESICR 16709 15510 ISENTFGIEESSDLEFKKKFMIAVDKMLFIVIERIRKIWLHNDFLYNYCTSLKKEEDNVV 15331 15330 KVLTDMTNK 15304 14587 VLHKKQALLKMKSPTEQPEQSKKS 14516 160 EKKFKALLDLLLDLSAEDSLTGPEILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEE 683 IKNVFGDSERDVESDDLSKLVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLK 519 520 AGRGCAINVYGINRHAMWGDDADKFRPERRLEPDGVPSVY*RVATFGVGKRACI 12885 GRTYAMMSMKTTLVHILRQFRIAADITKIEFKIEIILVPQTPCYLTLERRS* 12730 >CYP340E1 BAAB01132907.1 Length = 1852 exons 3,4 new 51% to CYPnew1bb 563 VITHPETAVTVADSTTSKHYIYSFFRRWLREGLLTSS 673 (1) 1013 GGVWKRHRKLVSPSFNLRVLYSFMGVFNSGSKKLINHFRDEMNKGPLNV 1159 >CYP340E1 CK533198 rswgb0_001141.y1 BAAB01126021.1 BAAB01203780.1 BAAB01034164.1 exon 10 overlaps EST seq., 45% to CYPnew1bb ENTFGIEESSDLEFKKKFMIAVDKMLFIVIERIRKIWLHNDFLYNYCTSLKKEEDNVVKVLTDMTNK VLHKKQALLKMKSPTEQPEQSKKS 160 EKKFKALLDLLLDLSAEDSLTGPEILEELNTAVFGGYDTTSCTLTYVLMNLGTYQDVQQKMYEE 683 IKNVFGDSERDVESDDLSKLVYTEAVIKESLRLYPIAPIIFRELDQDVKINNYTLK 519 520 AGRGCAINVYGINRHAMWGDDADKFRPERRLEPDGVPSVY*RVATFGVGKRACI 1006 GRTYAMMSMKTTLVHILRQFRIAADITKIEFKIEIILVPQTPCYLTLERRS* 1161 &&&&&&&&&&&&&&&& >CYP340F1 BAAB01090784.1 Length = 3359 new exons 7,8,9,10 45% to CYPnew1bb 2886 SLIDLLLNLSGDQVFSQEDIREEIDTVIVAAFDTTSWSLTYALLVLGSMPEIQEKVXXX 2719 2611 IEEVLGPTDRNLDKDDLQKLVYTEAMIKEVLRLYNVLPAVLRDITEKVQL 2462 1515 NYTMYPGDQCMILINNLNRHKAWGLDVEQFRPERWLGEAELPEHHSAYFATFGIGRRFCI 1336 GRIFAMYSMKTILVHILRRYSVKSDLAKLRLTSDYVTKPVSGHFITITRRINAVN* &&&&&&&&&&&&&&&& >CYP340-un1 pseudogene AADK01025706.1 = like CYP4S3 Bmb021357 I-helix region 277-344 BAAB01059276.1 44% to 4L4 CYP4C like Missing C-term and internal frag, possible pseudogene TWRNNRRLLNQAFKHTILDGFVDVFNNQARSLVDELAAEADLEKIYILNKLSLHSLRLVF TILGVSDQEVTPEKFNSYLETNNILHNIFTKRFQKFWLHSDIVFNRTKLKIEQDYAVAVLHG ELISNCGSQPSTYRPILLSSVMVIYFNSAFIVAGEQ KPFIDLLIEIAEEKGLSDMEVIHELATFIAAGHDTVPYTLLYTLMCVGSHPPVQQRIYEE AADK01040671.1 LQQVLGSDDVTKQNLSSLVYLEATIKETMRLYPIAPVVSRVTDCDVKLSKY missing about 14 aa at PKG motif LHHHPVWGSDVEHFKPERWLDPTTLPENAFAGFSTGKRNCI GKTFAMMSMKTTLAHLLRQTR C-term Perf to heme region 49% to 4S3 396-458 end of this seq is 76% identical to BAAB01034164.1 above &&&&&&&&&&&&&&&&&&&&&& >AADK01029578.1= BAAB01012981.1 Length = 2183 partial exon 7, 77% to CYP340A2 412 MLGLLLKGLDDDALTDREIRNEVDTLITAGSDTSS 308 exon 8 sequences >AADK01065909.1 = BAAB01083548.1 Length = 2923 new exon 8 1 aa diff to BAAB01023742.1, 79% to CYP340A4 286 SVANVDKHQHPRLVYREAVVKETLRLYPIGPILLRKAENEIKL 158 >AADK01030164.1= BAAB01023742.1 Length = 888 new exon 8 1 aa diff to BAAB01083548.1, 79% to CYP340A4 500 SVANVDKHQHPRLVYREAVVKETLRLYPIGPILLRKPENEIKL 628 >BAAB01117890.1 Length = 1882 new exon 8 1 aa diff to BAAB01083548.1 76% to CYP340A4 1814 SVANVDKHQHPRLVYREAVVNETLRLYPIGPILLRKAENEIKL 1686 >BAAB01108434.1 Length = 2407 frameshift, 4 aa diffs to CYP340A4 exon 8 CK536690.1 EST also has frameshift AADK01041079.1 1156 IKSVCGDSDADVDKLQHPRLVYTEAVVKET 1245 LRLYQIYSVVLRKTENEIKL 1303 exon 9 sequences More new families >CYP365A1 N-term 34% TO 9A1 BAAB01029726.1 BAAB01072071.1 AADK01000274.1 Whole sequence known but confidential THQFYQRT LVIRDPELIKRVCVNDFQHFVDRGFFFNKEVDPLAGSVLFLRGNEWKKLRAKISPIFS () PNKLRGMFPLIDNTADEFVIRLRKRIKNKNKDIENVDSNSNIED AYALVDSEELVGGYTADAIVPCAFGLKSLVMDKPDDPFAVALQAFYEKSLYNVFEK () TMRQFWPAFVLFFRMRIIPKKTHDFFHNVVTSVLRARESGKF >CYP365A1 C-term 42% TO 6D4 AA 308-458 BAAB01113890.1 BAAB01206962.1 Bmb040074 From Li Bin AADK01026272.1 Whole sequence known but confidential DIVISANAFIIFLGGFETTSSTLAFLFLELAADQRVQEKMRQEIREVLSRNDGKMTFEILQELIYMEMVIQ () ETLRLYPPFPSIQRMCTKDYLIPGTEKVVEKGTIVLFPTLGIQRDNQ YFERADDFYPERWSGGFVPPPGVYMPFGDGPRYCI >Simlar to CYP6CJ1 Louse P450 EST 40% CB887321 Lice_03_N06_T3 Body louse cDNA library Pediculus humanus cDNA. Length = 704 MDYYYVTLLIIIISALTWFIYALANRNCNY WKNRNVPYVSPVPFFGNLKSLLFLEKNVGEFLGDLYNSEKLPDHGFYGIYLTNNDPA LIIRDPELIRNICIKDFQHFSNRNATSDEKNDPLGYNNLFTLTGSKWKFIRTKLTPTFTSGKM KQMFTLVKETSDELIRYLNENSKEKNYTIMETKRF >and Pea aphid P450 EST 40% CF587676 USDA-FP_120600-031 Acyrthosiphon pisum, Pea Aphid Acyrthosiphon pisum cDNA clone WHAP-003_H03 5'. MLIFANFWIDFIILITVLFSIIYYYCTSTFNVWKK LNVPYIRPIPLFGNYLRVALGIENPMETYRKIYCELAGFKYGGMFQMRTPY LMIRDPEIINNILIKDFSYFTDRGIYVDFKTEPLSEVLFLMNNPRWKKFRSKLSPAFSSGKLKQMFNQI EKCGHDMINNIFAELKKNPHDIDMRDVVAKYSMDVIGSCAFGLTLM >CYP366A1 an--0429 new N-term http://www.ab.a.u-tokyo.ac.jp/silkbase/ BAAB01010488.1 BAAB01018170.1 BAAB01015588.1 BAAB01015589.1 AADK01020747.1, BY914303.1 EST 28% to 4G15 MLIMSEVLWCLLMLCACVWWWCSAPRRTRKLLAALPSFPQLPLLGNIHQIPRNSI NLFQFLEKIAVTCDTTEMPFVFWLGPRPIL FISDPEDVKGVNNAFIEKPHYYSFAKVWLGNGLVVAP PEIWKNSIKKLSGTFTPSIVEGYQEVFAGRAADLV 545 546 QRLKARTTEEPFDIMHDLAYTTLEAICQTAFG 641 >CYP366A1 35% to 4C37 BAAB01132146.1 BAAB01000816.1 ETAM exon Bmb038385 from Li Bin AADK01020849.1 best matches to CYP4C middle region ETAFGFPKISESIVTKEYYDAFHRCLELLIRRGLNPLLHLDFMYRLTPASKELQKCVGILHNVSNT () VITKLIQERECAKQDNRNEI () BAAB01011842.1 VPNRRRFKSFLDLMLEMQVSTPELSVEQIRSEVDTVLFGGHETVATTLFYALLMIGRDKNLQDK LYNEVRDVVGDGGRPVTGADLPRLRYCEATVLETLRLFPPFPAVLRMADKDLQLSSGI >CYP367A1 BAAB01019896.1 BAAB01107379.1 Bmb008200 from Li Bin AADK01004845.1 BAAB01014226 4 fam like 27% to 4C15 MLWPVIYLLALVFAYWPYWRWKNRRLLRLSASMPGPRALPIIGNGLLIVVNTGGKFNKTI (0) 4269 5077 LFRTYGDYCKIWLGPELNICVKNPDDIR (0) LLLTSNKVNQKGPAYEIMKAAIGPGILTG (1) 6651 GPTWRNHRKIVTPSYNKRAVKLYSAVFNREAEVLANLLLKKQSGVTFNVYYDVVEITTQCVC (1) 6836 8492 QTLIGLSKDDSRNVDGMSDLILETQN (2) 8569 9222 LYELLFTKMTVWWLQIPFVYWITGRKATENAYVKKIDRLTSDFLKKRRTALKGGNVDEESMGIVDRYI ASGELTEQEIKWETMTLFTTSQEASAKITSAVLLFLAHLPDWQEKVYKEIVEVIGSGRND VTAEHLKHLHYLDMVYQEALRYLSIAALIQRTVEEEITINNGKFTLPIGT TLVIPIHDLHRDPRYWDEPLKVKPERFLPENVKKRSPNVFIPFSLGAMDCLGRVYAEPLIKTLVVWAVRE VQLEAEGCVEDLKLHVAISVKFANGYNLKVKPRI* >CYP367B1 BAAB01152562 N-term 4 fam like 127 aa more seq known but confidential MISYMILIVIVFALMWSGWKQKNKKFMEMANQFPGPQALPFIGNALRFMCEPE      !  b c : ; 6 7 z { | ? @ A z {    [ \ 56rsh3OB*CJOJQJaJphh3O0JOJQJ^Jh3Ojh3OUh3OB*OJQJ^Jphh3O5B*\phK ! c ; 7 { | @ A {   \ edG2 6s 0Mrb9icdedG2  /0LMqr~ab89hibcd34op-.no"#WXvwUVh3O5B*\phh3OCJOJQJaJh3OB*CJOJQJaJphU4p.o#XwV-:IsedG2,-9:HIrs  GHIabcsvw 67cds*+KLswx89:NOs|h3OB*CJaJphh3OCJaJh3OCJOJQJaJh3O5B*\phh3OB*CJOJQJaJphMs HIbcw7d+Lx9:O}edG2edG2|}45  5IJ5NO   5 L M ! ! !#!$!%!5![!\!!!!!!! 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