P450s that have appeared since the 1993 P450 nomenclature update.

      This is Part B of the P450 bibiographic files.  
      Sequences covered are CYP3 to CYP9.

      This list now includes all Drosophila P450s

      This includes references that were incomplete and duplications
      of sequences that were already in the update.  If a sequence 
      is assigned an accession number that was not in the old update
      it is included in this list.  
      Added 4A23-4A25, 6X1 9J1, 9J2, 
      4F19 N-term (Jan 2002 added Fugu 3As and minipig 3A29v5)
      Added 6P2, 6P3, 6Y1, 6Z1, 9K1 added 6Z2, 6AA1, 6P4 and 9L1
      Added 4C31, 4C32, 4C33, 4C34, 4AN1, 4AN2, 4AN3, 4AP1, 4AP2

      Added all human genes and pseudogenes
      Added CYP8B1 pig
      Added 6AB3, 6AE1, 9A6 and 9A7, 4G19
      Added 25 Aedes and 104 Anopheles sequences
      Added CYP9G2
      This list was last revised on April 7, 2003. 
      Added Cyp3a58-ps to CYP3A62, wallaby 4B1, 4B3
      July 2, 2003 added 4F42, 3A64, 4T6, 4T7
      Last revised Aug 19 2003, added 9A12
      Last revised Sept 26, 2003 added accessions for some old seqs.
      Last revised July 8, 2004 added Anopheles funestus CYP9s
      Last revised Jan. 31, 2005 added Anopheles funestus CYP6s and 4C25
      Last revised March 17, 2005 added Anopheles funestus CYP9L4 and 9K1
      Last revised June 24, 2005
      Last revised Jan. 4, 2006
      Last revised Dec. 31, 2007
      Last revised June 22, 2010

3A Subfamily

3B Subfamily

3C Subfamily

3D Subfamily

4A Subfamily

4B Subfamily

4C Subfamily

4D Subfamily

4E Subfamily

4F Subfamily

4G Subfamily

4H Subfamily

4J Subfamily

4K Subfamily

4L Subfamily

4M Subfamily

4N Subfamily

4P Subfamily

4Q Subfamily

4R Subfamily

4S Subfamily

4T Subfamily

4U Subfamily

4V Subfamily

4W Subfamily

4X Subfamily

4Y Subfamily

4Z Subfamily

4AA Subfamily more CYP4 subfamilies follow

5A Subfamily

6A Subfamily

6B Subfamily

6C Subfamily

6D Subfamily

6E Subfamily

6F Subfamily more CYP6 subfamilies follow

7A Subfamily

7B Subfamily

8A Subfamily

8B Subfamily

9A Subfamily

9B Subfamily

9C Subfamily more CYP9 subfamilies follow


3A Subfamily

CYP3A1      rat
            GenEMBL D13912 (2023bp)
            Kirita,S. and Matsubara,T.
            cDNA cloning and characterization of a novel member of steroid-
            induced cytochrome P450 3A in rats
            Arch. Biochem. Biophys. 307, 253-258 (1993)
            Note: only 11 differences and two missing amino acids with 
            3A1.  All changes are limited to a 113 amino
            acid region, M10161 probably represents a hybrid seq. with Cyp3a2.
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            PIR S30378 (25 amino acids)
            Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
            M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
            Thomas, P.E.
            Regulation of two members of the steroid-inducible cytochrome
            P450 subfamily (3A) in rats.
            Arch. Biochem. Biophys. 301, 345-354 (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            GenEMBL L24207 (2015bp)
            Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
            Nucleotide and deduced amino acid sequences of a new rat CYP3A form.
            Unpublished (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            GenEMBL D29967 (2026bp) PIR S39797 (502 amino acids)
            Kirita,S. and Matsubara,T.
            cDNA cloning and characterization of a novel member of
            steroid-induced cytochrome P450 3A1 in rats.
            Arch. Biochem. Biophys. 307, 253-258 (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            GenEMBL M28452 (897bp)
            Wrighton,S.A., Schuetz,E.G., Watkins,P.B., Maurel,P., Barwick,J.,
            Bailey,B.S., Hartle,H.T., Young,B. and Guzelian,P.
            Demonstration in multiple species of inducible hepatic cytochromes
            P-450 and their mRNAs related to the glucocorticoid-inducible
            cytochrome P-450 of the rat
            Mol. Pharmacol. 28, 312-321 (1985)

            Komori,M. and Oda,Y.
            PIR JX0334 (502 amino acids)
            A major glucocorticoid-inducible P450 in rat liver is not 3A1.
            J. Biochem. 116, 114-120 (1994)
            Note 12 amino acid diferences and 1 two amino acid deletion vs 3A1
            Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.

CYP3A1      rat
            PIR S36137 (30 amino acids)
            Ribeiro, V. and Lechner, M.C.
            Cloning and characterization of a novel CYP3A1 allelic
            variant: Analysis of CYP3A1 and CYP3A2
            sex-hormone-dependent expression reveals that the CYP3A2
            gene is regulated by testosterone.
            Arch. Biochem. Biophys. 293, 147-152 (1992)
            This sequence agrees exactly with PIR JX0334, a 3A1 variant
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A1      rat
            PIR S27107 (24 amino acids)
            PIR S21697 (504 amino acids)
            Telhada,M.B., Pereira,T.M. and Lechner,M.C.
            Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
            Arch. Biochem. Biophys. 298, 715-725 (1992)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A2      rat
            GenEMBL M74443 (4230bp) U09725 to U09734 13 exons 
            Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
            A gene structure of testosterone 6-beta-hydroxylase (P450IIIA)
            Biochem. Biophys. Res. Commun. 177, 68-73 (1991)
            U09725-U09734 report corrections to M74443

CYP3A2      rat
            Gen EMBL X79319 (8014bp)
            Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
            Structure of a gene and cDNA of a major constitutive form of       
            testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
            unpublished (1994)

CYP3A2      rat
            GenEMBL X79320 (1936bp) PIR S46938 (504 amino acids)
            Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
            Structure of a gene and cDNA of a major constitutive form of
            testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
            unpublished (1994)

CYP3A2      rat
            GenEMBL U09742 (1936bp)
            Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
            Structure of a gene and cDNA of a major constitutive form of
            testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2: 
            Comparison of the cDNA with P450PCN2.
            unpublished (1994)

CYP3A2      rat
            Yamazoe,Y. et al. 
            Transcriptional elements directing a liver-specific expression of   
            P450/6bA(CYP3A2) gene encoding testosterone 6b-hydroxylase.
            Arch Biochem Biophys. 318, 71-79 (1995)

CYP3A2      rat
            PIR S30379 (25 amino acids)
            Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
            M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
            Thomas, P.E.
            Regulation of two members of the steroid-inducible cytochrome
            P450 subfamily (3A) in rats.
            Arch. Biochem. Biophys. 301, 345-354 (1993)

CYP3A2      rat
            GenEMBL S45634 (1572bp)
            PIR S27108 (36 amino acids)
            Telhada,M.B., Pereira,T.M. and Lechner,M.C.
            Effect of dexamethasone and phenobarbital on run-on transcription
            rate and CYP3A mRNA concentration in rat liver: changes during
            development
            Arch. Biochem. Biophys. 298, 715-725 (1992)

CYP3A2      rat
            UCSC Browser chromosome 12
9570862 MDLLSALTLETWVLLAVILVL 9570800
9570429 LYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK 9570328
9566707 GLGRFDMECYKKYGKIWG 9566654
9564529 LFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRR 9564431
9559660 DFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKE 9559547
9559467 MFPIIEQYGDILVKYLKQEAETGKPVTMKK 9559378
9559082 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSV 9558936
9556537 VLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHK 9556409
9555511 HRVDFLQLMLNAHNNSKDEVSHK 9555443
        ALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSK in a seq gap
9551883 APPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKG 
        SVVTIPTYALHHDPQHWPKPEEFHPE 9551659
9550394 RFSKENKGSIHPYVYLPFGNGPRNCIDMRFALMNMKLALTKVLQNFSFQPCKETQ 9550230
9547469 IPLKLSRQAILEPEKPIVLKVLPRDAVINGA 9547377

CYP3A3X     human
            PIR A25450 (504 amino acids) PIR A29410 (504 amino acids)
            Molowa, D.T., Schuetz, E.G., Wrighton, S.A., Watkins, P.B.,
            Kremers, P., Mendez-Picon, G., Parker, G.A. and Guzelian, P.S.
            Complete cDNA sequence of a cytochrome P-450 inducible by
            glucocorticoids in human liver.
            Proc. Natl. Acad. Sci. U.S.A. 83, 5311-5315 (1986)
            This number is discontinued the seq = CYP3A4

CYP3A4      human
            GenEMBL D11131 (1345bp)
            Hashimoto,H. Toide,K., Kitamura,R., Fujita,M., Tagawa,S.,
            Kamataki,T. and Itoh, S.
            Gene structure of CYP3A4 an adult-specific form of cytochrome
            P450 in human 
            livers and its transcriptional control.
            Eur. J. Biochem. 218, 585-595 (1993)

CYP3A4      human
            GenEMBL J04449 (2849bp)
            Bork,P., Muto,T., Beaune,P.H., Srivastava,P.K., Lloyd,R.S. and 
            Guengerich,F.P.
            Characterization of mRNA species related to human liver cytochrome 
            P-450 nifedipine oxidase and the regulation of catalytic activity.
            J. Biol. Chem. 264, 910-919 (1989)
            nf-10 nifedipine oxidase (IIIA3)

CYP3A4      Pan troglodytes (chimp)
            NM_001122775.1
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPL
PFLGNILSYRKGFCMFDMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREADTGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSIIVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI
DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLALIRVLQNFSFKPCKETQIPLKLRLGGLLQPEKPIVLKVESRDGTVSGA

CYP3A4      Macaca fasicularis (monkey)
            Formerly CYP3A8 but
            Renamed CYP3A4 to reflect orthology with human CYP3A4
            GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
            PIR S28168 (503 amino acids)
            Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
            and Kamataki,T.
            Molecular cloning of monkey liver cytochrome P-450 cDNAs:
            similarity of the primary sequences to human cytochromes P-450.
            Biochim. Biophys. Acta 1171, 141-146 (1992)
MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL
PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI
DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV
VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA

CYP3A4      Macaca fasicularis (monkey)
            Formerly CYP3A8 but
            Renamed CYP3A4 to reflect orthology with human CYP3A4
            Swiss P25231 (22 amino acids)
            Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and   
            Kamataki,T.
            Biochim. Biophys. Acta 996, 142-145 (1989)

CYP3A4      Macaca fasicularis (monkey)
            Formerly CYP3A8 but
            Renamed CYP3A4 to reflect orthology with human CYP3A4
            PIR S36875 (13 amino acids)
            Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
            Purification and characterization of two forms of hepatic microsomal
            cytochrome P450 from untreated cynomolgus monkeys.
            Arch. Biochem. Biophys. 305, 405-413 (1993)

CYP3A4      Macaca mulatta (rhesus monkey)
            Formerly named CYP3A64
            Analysis of the genomic DNA shows this gene is syntenic with 
            human CYP3A4 so it has been renamed CYP3A4
            NM_001040414
            Tom Rushmore, Merck & Co. Inc.
            Submitted to nomenclature committee 6/30/2003
            92% to CYP3A4
MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL
PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV
VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA

CYP3A4      Macaca mulatta (rhesus monkey)
            NP_001035504 
            UCSC Browser chr3:47026931-47056683 (-) strand
            syntenic with CYP3A4 human

CYP3A4      Pongo pygmaeus (orangutan)
            EF589794.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a4
            93% to 3A4 human
LAMETWILLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNV
FSYRKGFWRFDMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRPF
GPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIARYGDVLVRNLRREAET
GKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSII
VFPFLTPILEILNISVFPREVTSFLRKSVKRMKESRLKDTQKHRVDFLQLMIDSQNSK
ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQRKLQEEIDAVLP
NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPS
YALHHDPKYWTEPGKFLPERFSKKNKDNIEPYVYTPFGTGPRNCIGMRFALMNMKLAV
IRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKVESRDG

CYP3A4      Papio anubis (baboon)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            baboon3a4
            93% to 3A4 human

CYP3A4      Callithrix jacchus (marmoset)
            GenEMBL D31921
            Igarishi, T. 
            Unpublished
            Renamed CYP3A4 based on synteny and placement on phylogenetic trees
            Formerly CYP3A21

CYP3A4-ie1b human = CYP3A4P1
            GenEMBL NT_007933.10|Hs7_8090
            alt exon 1 (partial)
            24614522   LIPNLAVETWLLL 24614484 

CYP3A4-ie1b Macaca mulatta (rhesus monkey)
            UCSC browser chr3: 47055991-47055947 (-) strand
            Ortholog of human CYP3A4-ie1b internal duplicate exon 1
            47055991 MDLIPNLAMET*LLL 47055947

CYP3A4v1    Cercopithecus aethiops (African green monkey)
            No accession number 
            Catherine Booth-Genthe
            Merck Research laboratories
            92% to human CYP3A4, 88% to human CYP3A7

CYP3A4v2    Cercopithecus aethiops (African green monkey)
            No accession number 
            Catherine Booth-Genthe
            Merck Research laboratories
            92% to human CYP3A4, 88% to human CYP3A7
            1 aa diff to 3A4v1, 4 nuc. diffs

CYP3A4frag  Tupaia belangeri (northern tree shrew)
            AY699817
LMINSQNSKEMESHKALTDLELVAQSIIFIFAGYETTSSILSFI
MYTLAIHPDVQKKLQEEVDATFPNKAPPTYDALMQMEYLDMVVNEVLRLYPVAGRLER
VCKKDV

CYP3A4P1    human = CYP3A4-ie1b
            GenEMBL NT_007933.10|Hs7_8090
            alt exon 1 (partial)
            24614522   LIPNLAVETWLLL 24614484 

CYP3A5_v1   human
            PIR A60558 (29 amino acids)
            Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M.
            Identification of a polymorphically expressed member of the
            human cytochrome P-450III family.
            Mol. Pharmacol. 36, 97-105 (1989)

CYP3A5_v1   human
            GenEMBL S74699 (1526bp) S74700 (1667bp)
            Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
            Sequence of the 5'-flanking region of CYP3A5: comparative analysis
            with CYP3A4 and CYP3A7.
            Biochem. Biophys. Res. Commun. 205, 1741-1747 (1994)

CYP3A5_v1   human
            GenEMBL AC005020 genomic sequence 13 exons
            Same intron exon structure as CYP3A43 from human

CYP3A5-de1b2b human
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 
            alt exon 1 and 2 upstream of 3A5
            239409 MDLIPNLAVETWLLLAVSLVLLYL
            243605 YGAHSHGLFKKLGIPGPTPLLFLGTTLSYHQ 243697

CYP3A5-de13c human = CYP3A51P
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 detritus exon 13 upstream of 3A5
            old name = 3A51P, note: this name is being used by the HGNC
            254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
            because the HGNC has strict rules for gene names,
            The old names (CYP3A51P, etc.) are being used by the HGNC
            These will be synonyms. 

CYP3A5_v2   human
            GenEMBL L26985 (1599bp)
            Schuetz,J.D.
            unpublished (1994)
            formerly CYP3A5P1, new name = CYP3A5_v2 short for: 
            CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
            14n, 15n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5-de1b2b3b14n4b15n  Macaca mulatta (rhesus monkey)
            between CYP3A7 and CYP3A5 there is a pseudogene 
            containing 6 exons, including the cryptic exons 14n and 15n
            found in the human alt. splice form CYP3A5_v2
            This pseudogene is syntenic with human CYP3A5_v2
            But in humans the cryptic exons exist inside the 3A5 gene 
            not outside it.  This suggests a deletion event happened in humans.
            Loss of the first 4 exons in the ancestral 3A5 gene would make
            The current human gene possible. 
            82% to CYP3A5_v2 alt splice from the CYP3A5 gene
MDLIPNLAVETWLLLAVSLVLLYL (2)  exon 1
YGAHSHGLFKKLGIPGPTPLPFLGTTLSYRQ (0) exon 2
GLWKFDTECYKKYGKMWR (2) exon 3
SSLFGPHYPSSYEDLNDSYVRLLLCVTP**TRT*DCYALHNWG ()    cryptic exon 14n
YKGQQPVLAITDPNMTKTVLVKEYYSVFTNQR (0) exon 4
ICATTSMIKMQTHSITMWLPPAILQSQ     cryptic exon 15n

CYP3A5_v3   human
            GenEMBL X90579 (?bp)
            Maurel,P. and Jounaidi,Y.
            unpublished (1995)
            note: a second pseudogene similar to CYP3A5P1
            formerly CYP3A5P2, new name = CYP3A5_v3 short for: 
            CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
            14n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5P1X   human
            GenEMBL L26985 (1599bp)
            Schuetz,J.D.
            unpublished (1994)
            new name = CYP3A5_v2 short for: 
            CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
            14n, 15n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5P2X   human
            GenEMBL X90579 (?bp)
            Maurel,P. and Jounaidi,Y.
            unpublished (1995)
            note: a second pseudogene similar to CYP3A5P1
            new name = CYP3A5_v3 short for: 
            CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
            14n and 16n are cryptic exons, delta = deleted
            exon 10ax means exon 10 is extended downstream
            this is an alternative transcript not a pseudogene

CYP3A5      Pan troglodytes (chimp)
            NM_001093777
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL
PLLGNVLSYRQGLWKFDTECYKKYGKMWGMYDGQLPVLAITDPDMIRTVLVKECYSVF
TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL
RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP
LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI
DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE
IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS
MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN
MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE

CYP3A5    Pan troglodytes (chimpanzee)
          EF589798.1
          99% (3 aa diffs) to human
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL                      PLLGNVLSYRQGLWKFDTECYKKYGKMWGMYDGQLPVLAITDPDMIRTVLVKECYSVF                      TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL                      RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP                      LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI                      DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE                      IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS                      MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN                      MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSG

CYP3A5      Macaca mulatta (rhesus monkey)
            No accession number
            Brian A. Carr, Merck & Co. Inc.
            Submitted to nomenclature committee 4/22/2004
            91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
            name has been changed to indicate orthology formerly CYP3A66

CYP3A5      Macaca mulatta (rhesus monkey)
            NM_001040219
MDLIPNLAMETWLLLAVSLVLLYLYGTRSYGLFKRQGIPGPTPL
PFLGNILSYRQGLWKFDTECYKKYGKMWRTQDGQLPVLTITDPEMIKTVLVKECYSVF
TNRRPLGPVGLMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDMLVRNL
RREAEKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPKDPFVESVKKFLKFDFLDP
LFLLTILFPFLTPAFEALNVSLFPKDAINFLNKSVNSMKKSRLNDKQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQKE
IDAVLPNKAPATYDAMVQMEYLDMVVNETLRLFPIAIRLERACKKDVEINGVFIPKGA
MVVIPTYALHHDPKYWTEPEEFRPERFSKKNKDSIDPYIYTPFGTGPRNCIGMRFALM
NMKLAIIKVLQNFSFKPCKETQIPLKLGNQGLLQSEKPIVLKVESRDGTLSGE

CYP3A5      Macaca fasicularis (cynomolgus monkey)
            DQ074795
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP3A5_2-F5
            3 aa diffs to 3A5 Macaca mulatta
MDLIPNLAMETWLLLAVSLVLLYLYGTRSYGLFKRQGIPGPTPL
PFLGNILSYRQGLWKFDTECYKKYGKMWRTQDGQLPVLTITDPDMIKTVLVKECYSVF
TNRRPLGPVGLMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDMLVRNL
RREAEKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPKDPFVESVKKFLKFDFLDP
LFLLTILFPFLIPAFEALNVSLFPKDAINFLNKSVNSMKKSRLNDKQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQKE
IDAVLPNKAPATYDAMVQMEYLDMVVNETLRLFPIAIRLERACKKDVEINGVFIPKGA
MVVIPTYALHHDPKYWTEPEEFRPERFSKKNKDSIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIKVLQNFSFKPCKETQIPLKLGNQGLLQSEKPIVLKVESRDGTLSGE

CYP3A5      Macaca fasicularis (cynomolgus monkey)
            No accession number
            Wu Zhicong
            Submitted to nomenclature committee 10/30/2006
            91% to 3A5 human, 84% to 3A4, 80% to 3A7, 75% to 3A43
            100% identical to Unos seq.

CYP3A5      Callithrix jacchus (marmoset)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Cja3a5b
            89% to 3A5 human, probable ortholog of CYP3A5
            note: there is a second gene CYP3A90 that is 95% identical to this
            it is a paralog of the CYP3A5 gene

CYP3A5      Pongo pygmaeus (orangutan)
            EF589795.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a5
            98% to 3A5 human
WLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQ
GLWKFDTECYKKYGKMWGTYDGQLPVLAITDPDMIKTVLVKECYSVFTNRRSLGPVGF
MKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFSFLDPLFLSIILFPFL
TPVFEALNVSLFPKDTINFLNKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH
KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP
TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGAMVVIPTYALHH
DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN
FSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGE

CYP3A6      rabbit 
            GenEMBL J05034, M19139

CYP3A7      human
            NM_000765
MDLIPNLAVETWLLLAVSLILLYL
YGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

CYP3A7-de1b2b human
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 alt exon 1 and 2 upstream of 3A7
            186958 xxLIPNLAVETWLLLAVSLVLHYL + ex 1
            191087 VSLCRYETHSHGLFKNLGIPGPRPLLFLGTTLSYHQ 191194 + ex 2

CYP3A7      Pan troglodytes (chimp)
            UCSC genome browser chr7:100320611-100350193
            3 aa diffs to human
MDLIPNLAVETWLLLAVSLILLYL YGTRTHGLFKKLGIPGPTPL PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF TNRRPFGPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL RREAETGKPVTLKHVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNPLDP FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI DSQNSEDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

CYP3A7      Cercopithecus aethiops (African green monkey)
            No accession number 
            Catherine Booth-Genthe
            Merck Research laboratories
            89% to human CYP3A7, 89% to human CYP3A4
            82% to human 3A5 and 73% to 3A43
            note: this seq is equally similar to 3A7 and 3A4
            but there is another seq with a better match to 
            3A4 in African green monkey, so this must be
            the 3A7 ortholog

CYP3A7      Pongo pygmaeus (orangutan)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a7
            96% to 3A7 human

CYP3A7      Papio anubis (baboon)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            baboon3a7-like
            92% to 3A7 human

CYP3A7      Macaca mulatta (rhesus monkey)
            AANU01101873.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            mmul3a7-like
            UCSC browser chr3:46903541-46929928 (-) syntenic with CYP3A7
            91% to CYP3A7 human, 88% to CYP3A4, 82% to CYP3A5
24981 MDLIPDLAVETWLPLAVSLILLYL
      YGTHSHGLFKKLGIPGPTPLPFFGNVLSFRK  29288
34310 GFWTFDMECYKKYRKVWG  34363
35908 FYDCRQPVLAITDPNMIKTVLVKECYSVFTNRR  36006
38516 PLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKE  38629
38894 MVPIIAQYGDVLVRNLRREAETGKPVTLKD  38983
40270 VFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDPFFLSIK 40416
41507 IFPFLTPIFEALNITVFPRKVTRFLRKSVKRMKEGRLKETQK  41632
42652 RRVDFLQLMIDSQNSKDTESHK  42717
45311 VLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKEIDTVLPNK 45472
46900 APPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGVVVMIP 
47094
47095 SYVLHHDPKYWTEPEKFLPER
48220 RFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ  48384
51270 IPLKLSFGGLLKTEKPIVLTAESRDGTVSGA*  51371

CYP3A7     Macaca fascicularis (cynomolgus monkey)
           AB206123
MDLIPDLAVETWLPLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFFGNVLSFRKGFWTFDMECYKKYRKVWGFYDCRQPVLAITDPNMIKTVLVKECYSVF
TNRRPLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDP
FFLSIKIFPFLTPIFEALNITVFPRKVTSFLRKSVKRIKEGRLKETQKRRVDFLQLMI
DSQNSKDTASHKVLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKE
IDTVLPNKAPPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKLALIRVLQNFSFKPCKETQIPLKLSFGGLLKTEKPIVLTAESRDGTVSGA

CYP3A8X     Macaca fasicularis (monkey)
            Renamed CYP3A4 to reflect orthology with human CYP3A4
            GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
            PIR S28168 (503 amino acids)
            Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
            and Kamataki,T.
            Molecular cloning of monkey liver cytochrome P-450 cDNAs:
            similarity of the primary sequences to human cytochromes P-450.
            Biochim. Biophys. Acta 1171, 141-146 (1992)

CYP3A8X     Macaca fasicularis (monkey)
            Renamed CYP3A4 to reflect orthology with human CYP3A4
            Swiss P25231 (22 amino acids)
            Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and   
            Kamataki,T.
            Biochim. Biophys. Acta 996, 142-145 (1989)

CYP3A8X     Macaca fasicularis (monkey)
            Renamed CYP3A4 to reflect orthology with human CYP3A4
            PIR S36875 (13 amino acids)
            Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
            Purification and characterization of two forms of hepatic microsomal
            cytochrome P450 from untreated cynomolgus monkeys.
            Arch. Biochem. Biophys. 305, 405-413 (1993)

CYP3A9      rat
            GenEMBL U46118(2101bp)
            Wang,H., Kawashima,H. and Strobel,H.W.
            cDNA cloning of a novel CYP3A from rat brain
            Biochem. Biophys. Res. Commun. 221 (1), 157-162 (1996)

CYP3A9      rat
            GenEMBL U60085(1882bp)
            Nef,P.
            Hepatic expression and inducibilty of CYP3A9 and other members of
            the rat CYP3A subfamily.
            unpublished (1996)

CYP3A9      rat
            UCSC Browser chromosome 12
some frameshifts in genome seq of exon 8
17153442 MDLIPNFSMETWLLLVISLVLLYL 17153513
17155488 YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK 17155580
17156990 GFWEFDKYCHKKYGKLWG 17157043
17159222 LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17159320
17163193 NFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKE 17163306
17163523 MFPIINQYTDMLVRNMRQGSEEGKPTSMKD 17163606
17165013 IFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSV 17165159
17168128 TLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKE 17168226 NRMKEKEK
17170690 QRMDFLQLMINSQNSKVKDSHK 17170755
17177660 ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK 17177821
17179040 AHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGT
         VVMIPTFALHKDPHYWPEPEEFRPE 17179264
17191573 RFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKET 17191734
17192800 QIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA 17192895

CYP3A9-se1[4]X rat
              UCSC Browser chromosome 12
              Note: the revised genome probably has this as part of Cyp3a62
              Discontinued name
17387311 LYEGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17387213 exon 4 

CYP3A9-se1[1:2:4] rat
          193 kb downstream of Cyp3a9 on opposite strand
          100% match to Cyp3a9
MDLIPNFSMETWLLLVISLVLLYL
YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK
LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR

CYP3A10     hamster
            GenEMBL M73992 (2015bp)
            Miyata,M., Nagata, K., Yamazoe,Y. and Kato,R.
            Nucleotide and deduced amino acid sequence of a new rat CYP3A form
            unpublished (1993)

Cyp3a11     mouse
            PIR A60564 (24 amino acids)
            Bornheim, L.M. and Correia, M.A.
            Purification and characterization of a mouse liver cytochrome
            P-450 induced by cannabidiol.
            Mol. Pharmacol. 36, 377-383 (1989)

Cyp3a11     mouse
            GenEMBL X60452, AC111090.20 genomic clone (seq shown)
104114 MDLVSALSLETWVLLAISLVLLYR 104185
106160 YGTRKHELFKKQGIPGPKPLPFLGTVLNYYK 106252
108416 GLWKFDMECYKKYGKTWG 108469
110360 LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR 110458
114653 DFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKE 114766
114846 MFPVIEQYGDILVKYLRQKAKKGKPVTMKD 114935
115207 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSV 115353
117878 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQK 118006
118896 HRVDFLQLMMNSHNNSKDKVSHK 118964
121382 ALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNK 121543
123352 APPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALH
       HDPQHWSEPEEFQPER 123579
125008 FSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQ 125169
128728 IPLKLSRQGLLQPEKPIVLKVVPRDAVITGA 128820

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Cyp3a11-de12bX mouse
           old name Cyp3a-se11[12] also = Cyp3a-se6[12]
           this fragment has joined with Cyp3a44-de9b10b11b
           to make Cyp3a44-de9b10b11b12b (see below)
137165 RFSMENKGSIDPY 137127
137122 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 136997

CYP3A12     dog
            PIR S04341 (28 amino acids)
            Ciaccio, P.J. and Halpert, J.R.
            Characterization of a phenobarbital-inducible dog liver
            cytochrome P450 structurally related to rat and human
            enzymes of the P450IIIA (steroid-inducible) gene subfamily.
            Arch. Biochem. Biophys. 271, 284-299 (1989)

Cyp3a13     mouse
            GenEMBL X63023(1881bp) also NT_039315.1
            Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
            Molecular cloning and functional expression of a mouse cytochrome
            P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
            aflatoxin B1 (AFB1).
            Biochim. Biophys. Acta 1201 (3), 405-410 (1994)

CYP3A14     Cavia cobaya (guinea pig)
            GenEMBL D16363 (1827bp)
            Mori,T., Itoh,S. and Kamataki,T.
            cDNA and deduced amino acid sequence of a novel cytochrome
            P450 from male guinea pig liver mRNA with high homology to 
            CYP3a family
            unpublished (1993)

CYP3A14     Cavia porcellus (guinea pig)
            GenEMBL D49731 (2321bp)
            Mori,T., Itoh,S. and Kamataki,T.
            Differential effects of ascorbic acid deficiency on the expression
            of the forms of cytochrome P450.
            Unpublished (1995)

CYP3A15     Cavia cobaya (guinea pig)
            GenEMBL D26487 (2163bp)
            Mori,T., Itoh,S. and Kamataki,T.
            Differential effects of ascorbic acid deficiency on the expression
            of the forms of cytochrome P450.
            Unpublished (1995)

Cyp3a16     mouse
            GenEMBL D26137 (1701bp) also NT_039318 
            Itoh,K., Satoh,M., Abe,Y., Hashimoto,H., Ynagimoto,T. and Kamataki T.
            A novel form of mouse cytochrome P450 3A (Cyp3a16). Its cDNA cloning 
            and expression in fetal liver.
            Eur. J. Biochem. 226, 877-882 (1994)

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Cyp3a16-de12b mouse 
           GenEMBL NT_039318 - strand 
           detritus exon 12
           z in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1616751 GPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1616647

CYP3A17     guinea pig 
            GenEMBL D28515 
            Mori,T.
            submitted to Nomenclature Committee 
            Not in Genbank as of 6/26/95

CYP3A18     rat
            no accession number
            Kiyoshi Nagata
            6-beta-C
            submitted to Nomenclature Committee 

CYP3A18     rat
            GenEMBL X79991 (2005bp)
            Strotkamp,D., Roos,P.H. and Hanstein,W.G.
            A novel CYP3 from female rats.
            Biochim. Biophys. Acta 1260, 341-344 (1994)

CYP3A18     rat
            GenEMBL D38381 (?bp) (not in GenBank yet,1/30/97)
            Yamazoe,Y. et al. 
            Isolation and characterization of of a new rat P450 (CYP3A18) cDNA 
            encoding P4506b-2 catalyzing testosterone 6b- and 16a-hydroxylations.
            Pharmacogenetics in press (1995)

CYP3A18     rat
            UCSC Browser chromosome 12
9166475 MEIIPNLSIETWVLLATSLMLFYI 9166404
9156355 YGTYSHGLFKKLGIPGPKPVPLFGTIFNYGD 9156263
9143764 GMWKFDDDCYKKYGKIWG 9143711
9141173 FYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRR 9141075
9137566 CFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKE 9137453
9136038 MFPLMRQYGDTLLKNLRREEAKGEPINMKD 9135949
9135719 IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSV 9135573
9133657 VLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQK 9133529
9132027 NRVDFLQLMMNTQNSKGQESQK 9131965
9129047 ALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNK 9128886
9126077 APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT
        VVTIPIYPLHRNPEYWLEPEEFNPE 9125853
9120566 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT 9120405
9117192 QIPLKISRQPIFQPEGPIILKLVSRD 9117115

CYP3A18-se1[5:6:7:8]   rat
            UCSC Browser chromosome 12
64% to 3A18
9216052 FGPVGFMKKAVTISEDDEGKRLRPLLSPVFTSGK 9216153
9216386 LWLLHFGLMCSPSSGSVMSVKHLRQEEKGEPIHMKE 9216493
9216722 FSGAYSMNGIAGASFGVNVDSLNN 9216781
XXXXXXXXXXXXXXXXXXXXXXXX
VVLFPFLTQI

CYP3A19     Capra hircus (goat)
            GenEMBL X76503 (1084bp)
            Zeilmaker,W.M., Van 't Klooster,G.A.E., Gremmels-Gehrmann,F.J.,
            Van Miert,A.S.J.P.A. and Horbach,G.J.M.J.
            cDNA and deduced amino acid sequence of a dwarf goat liver
            cytochrome P450-fragment belonging to the CYP2C gene subfamily
            Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
            C-terminal fragment from I-helix to end

CYP3A20     Guinea pig 
            GenEMBL 
            T. Mori
            unpublished

CYP3A21X    Callithrix jacchus (marmoset)
            GenEMBL D31921
            Igarishi, T. 
            Unpublished
            Renamed CYP3A4 based on synteny and placement on phylogenetic trees

CYP3A22v1   Miniature pig
            GenEMBL AB006010
            Sakuma,T., Shimojima,T., Miwa,K. and Kamataki,T.
            Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
            Drug Metab. Disp. 32, 376-378 (2004)

CYP3A22v2   Sus scrofa (pig)
            AK233355 
            Uenishi,H., Eguchi,T., Suzuki,K., Sawazaki,T., Toki,D., Shinkai,H.,
            Okumura,N., Hamasima,N. and Awata,T.
            PEDE (Pig EST Data Explorer): construction of a database for ESTs
            derived from porcine full-length cDNA libraries
            Nucleic Acids Res. 32 (DATABASE ISSUE), D484-D488 (2004)
            This seq has 8 aa diffs to CYP3A22 and is an exact match to the
            hybrid seq CYP3A46v2 last 61 aa
MDLIPSFSVETWL
LLATSLVLLYLYGTYSHGLFKKLGIPGPKPLPYFGSVLEYRKGMWHFDNKCFKKYGKMWG
FYDGRQPVLAMRDPEMIKAVLVKECYSAFTNRRNFGPAGVMKNAISVAKDEQWKRVRTLL
SPTFTSGKLKEMFPIIAQYGDMLVRNLRKEAEKGNSINTKEIFGAYSMDVITSTAFGVNV
DSLNNPRGPFVQYARKLLRFDFLDPFILSIILFPFLSPFFEVLDITLFPRSSAKFFTQSV
KRMKESRLKDQQMRRVDLLQLMINSQNSKETDAHKALSDQELVAQSIIFIFAGYETTSSS
LSFLAYILATHPDVQQKLQEEIDATFPSKALPSYDSLAQMEYLDMVVNEILRLYPIAARL
ERVCKKDVEIHGVSVPKGTVMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDTINPYTYL
PFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKV
VPRDGTVSGA

CYP3A23     rat 
            GenEMBL D13912
            Kirita,S. and Matsubara,T.
            Cloning and characterization of a novel member of steroid induced 
            cytochrome P450 3A in rats.
            Arch. Biochem. Biophys. 307, 253-258 (1993)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A23     rat 
            GenEMBL D29967
            Komori,M. and Oda,Y.
            A major glucocorticoid inducible P450 in rat liver is not P4503A1
            J. Biochem. 116, 114-120 (1994)
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.

CYP3A23     rat 
            UCSC Browser chromosome 12
            Note: 3A1 and 3A23 are the same gene.  3A23 is the accurate seq.
9625823 MDLLSALTLETWVLLAVVLVLLY 9625755
9623782 GFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM 9623687
9621110 GLWKFDVECHKKYGKIWG 9621057
9617991 LFDGQMPLFAITDTEMIKNVLVKECFSVFTNRR 9617893
9616272 DFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKE 9616159
9616079 MFPVIEQYGDILVKYLRQEKGKPVPVKE 9615996
9615715 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSV 9615569
9614012 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDS 9613893
9613004 VQKHRVDFLQLMMNAHNDSKDKESHT 9612936
9607896 ALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNK 9607735
9605981 APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKG
        SVVMIPSYALHRDPQHWPEPEEFRPE 9605757
9604349 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET 9604188
9597247 QIPLKLSRQGLLQPTKPIILKVVPRDEIITGS 9597152

CYP3A24     sheep
            GenEMBL U59378(1653bp)
            Ching,M.S., Chun-Jing,J., Ghabrial,H., Wookey,P.J., Smallwood,R.A.
            and Morgan,D.J.
            Ovine foetal liver CYP3A24
            unpublished (1996)

Cyp3a25     mouse
            GenEMBL AF204959
            Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
            submitted to Nomenclature Committee 10/18/96
            Cloning, sequencing, heterologous expression and characterization
            of murine Cytochrome P450 3A25, a 6B-Testosterone hydroxylase
            Unpublished
MELIPNLSIETWVLLVTSLVLFYI
YGTYSHGLFKKLGIPGPKPLPLLGTIFNYYD
GMWKFDEDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
FFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPISMKD
IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKVFDPFLLS
IILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQK 
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ
IPLKISREPIFQPEKPIILKVVSRDKPRTGS

Cyp3a25     mouse
            GenEMBL Y11995
            Mahnke,A., Roos,P. and Hanstein,W.G.
            one amino acid difference with Roses sequence at amino acid 215
            unpublished

Cyp3a25     mouse
            GenEMBL AC111090.20 genomic clone
            Last two exons.  This clone also contains CYP3a11, Cyp3a44 and the 
            region between them.  This helps to close the gap in the 3a cluster
            shown in Fig 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
2345 FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 2506
6188 IPLKISREPIFQPEKPIILKVVSRDKPRTGS 6280

Cyp3a25-de8b9b12b mouse
            GenEMBL AC111090.20 genomic clone
            r in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
27841 PVFFSFLIPI*EMLNISVFQKGSIAFFKKFVDRMNESRPDSKQK 27710
18903 DLVGFLQPMINAHNNPKDKESHNG 18832
15460 XXXXXXGSID-YVYLSFGNGPRIYIGVRFTLMNMKVLTLTKVLHNFSFHPCKET* 15317

Cyp3a25-de11c mouse
           GenEMBL NT_039324.1 - strand 
           detritus exon 11
           q in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
168333 XPVTLGTLVEIEYPDMVVT*ILILYPIGNRPESVCKEGFEVFIPKGTRVTVPTFALH*DPQYWPELEKXXXXX 168133

CYP3A26     dog
            no accession number
            David Fraser
            submitted to Nomenclature Committee 
            95.6% identical to 3A12 from dog

CYP3A27     Oncorhynchus mykiss (rainbow trout)
            GenEMBL U96077
            Don R. Buhler
            Arch. Biochem. Biophys. 360, 000-000 (1998) in press
            56% identical to 3A12

CYP3A28     Bos taurus (cow)
            GenEMBL Y10214(1870bp)
            Natsuhori,M., van Raak,M., Ligtenberg,M., Kleij,L., ten Berge,D.,
            Zweers-Zeilmaker,W.M., de Groene,E.M., Van Miert,A.S.J.P.A.,
            Witkamp,R.F. and Horbach,G.J.
            Isolation of a full length cytochrome P450 (CYP3A) cDNA sequence
            and its functional expression in V79 cells.
            unpublished (1997)

CYP3A28     Bos taurus (cow)
            See cattle page for details
MELIPSFSMETWVLLATSLVLLYI (2)
YGTYSYGLFKKLGIPGPRPVPYFGSTMAYHK (0)
GIPEFDNQCFKKYGKMWG (2)
FYEGRQPMLAITDPDIIKTVLVKECYSVFTNRR (0)
IFGPMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKE (0)
MFPIIGQYGDMLVRNLRKEAEKGNPVNMKD (2)
MFGAYSMDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSI (1)
ILFPFLNPVFEILNITLFPKSTVDFFTKSVKKIKESRLTDKQM (0)
NRVDLLQLMINSQNSKEIDNHK (1)
ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNK (0)
APPTYDALVQMEYLDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPER (2)
FSKNNKDSINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQ (0)
IPLKLYTQGLTQPEQPVILKVVPRGLGPQVEPDFL*

CYP3A29v1   pig
            GenEMBL Z93099 (2015bp)
            Nissen,P.H., Winteroe,A.K. and Fredholm,M.
            Characterization and mapping of three porcine genes belonging to
            the cytochrome P450 superfamily
            Unpublished
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVF
TNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDP
FLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI
NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEE
IEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGT
VVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGTVSGA

CYP3A29v2   Sus scrofa (pig)
            GenEMBL AB052260 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            2 amino acid diffs with 3A29v1
              clone name 3Ac9

CYP3A29v3   Sus scrofa (pig)
            GenEMBL AB052261
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            1 amino acid diff with 3A29v1
              clone name 3Ac16

CYP3A29v4   Sus scrofa (pig)
            GenEMBL AB052262
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            1 amino acid diff with 3A29v1, 2 aa diffs with 3A29v3
              clone name 3Ac25

CYP3A29v5  Sus scrofa (mini pig)
     GenEMBL AF424780
     Soucek,P., Zuber,R., Anzenbacherova,E., Linka,M. and Anzenbacher,P.
     cDNA of minipig cytochrome P450 3A
     Unpublished
     75% to 3A4 human 98% to 3A29v1 8 diffs.  
     3 diffs with 3A29v3 and v4 (Partial seqs from 99-328)
     4 diffs with 329v2 (Partial seq from 99-328)
     
CYP3A30     Fundulus heteroclitus
            Genbank AF105068
            Malin Celander and John J. Stegeman
            Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the 
            marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A 
            genes. 
            Biochem. Biophys. Res. Commun. 236, 306-312 (1997)
MGYFYLTAETWTLLVAFVTLLLVYAYWPYGTFKRLGISGPKPVP
FFGTMLHYRRGFFTFDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFT
NRRNFRLNGPLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMK
KKADKDEPLDLKEFFGSYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPL
FLAVAFFPFLGPILEKFELSFFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMID
SQKNSGAQQDKSLTDHEILSQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEI
DATFPNKAPVHYQPLMEMEYLDCVINESLRLFPIAARLERVAKAAVEINGVVIPKDMV
VMIPTWPLHRDPEIWPEPEAFKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVL
IKLAVVEILQQYSFSVCKETEVPFEMDIQGLLAPKRPIQLKLVPRS

CYP3A31     Syrian hamster
            GenEMBL D86951
            Alabouch,S., Kurose,K., Tohkin,M., Bani,M.H., Fukuhara,M.,
            Nagata,K. and Yamazoe,Y.
            cDNA cloning and expression of a novel CYP3A from the Syrian
            hamster, CYP3A31
            Biochim. Biophys. Acta 1397, 9-13 (1998)
            clone name P450SH3A-1

CYP3A32     Balaenoptera acutorostrata  (Minke whale)
            AB014349
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98
VITGIAFGVNIDSLNNPQDPFVEYSKKILKFNLLSPLLLSIVLF
PFLTPVFEALNITLFPKSSLNFLTKSVKRIKESRLKDKQTHRVDFLQLMINSQNSKET
DTHKVLSDTELMAQSIIFIFAGYETTSNSLSFIIYELATHPDVQQKLQEEIDATFPNK
APPTYEALVQ

CYP3A33     Phocoenoides dalli (Dall's porpoise)
            no accession number
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98

CYP3A34     Eumetopias jubatus (Steller sea lion)
            AB014351
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98
VITSTSFGVNIDSLNNPQDPFVENTKKLLKFDFLNPFLFSLLLF
PFLAPVFEMLNIWLFPKRVTDFFTKSVQRMKESRLKDKQKHRVDFLQLMINSQNSKEV
NTHKTLSDLELVAQSIIFIFAGYETTSTSLSFLVYELATHPDVQQKLQEEIDATFPNK
ALPTYDALLQ

CYP3A35     Phoca largha (Spotted seal)
            AB014352
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98
VITSTSFGVNIDSLNNPQDPFVENIKNFLKFDFLDPLFFSMLLF
PFLIPVFEKLNISLFPKSVTDFFMKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEI
DTYKALSDLELVAQSIIFIIAGYETTSTSLSFLVYELATHPDVQQKLQEEIDVTFPNK
ALPTYDALLQ

CYP3A36     Phoca fasciata (Ribbon seal)
            AB014353
            Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
            submitted to nomenclature committee 5/15/98
VITSTSFGVNIDSLNNPQDPFVENIKNFLKFDFLDPLFFSMLLF
PFLIPVFEKLNISLFPKSVTDFFMKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEI
DTYKALSDLELVAQSIIFIIAGYETTSTSLSFLVYELATHPDVQQKLQEEIDATFPNK
ALPTYDALLQ

CYP3A37     Gallus gallus (chicken)
            no accession number
            Manuel Baader and Urs Meyer
            submitted to nomencalture committee
            60% identical to mammalian CYP3A sequences

CYP3A37     Gallus gallus (chicken)
            GenEMBL NM_001001751.1
            Note: chicken has two CYP3As about 25kb apart on chr 14
            These two genes are in the same location as human
            Pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
            See CYP3A80
MNFLPFFSIETWIILLIFVVLLIIYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLDFDTECFQKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRTDLAGVLRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKYFGEMLVKNI
QKRVEKNSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
VFILSFVCPFLTPLMAKMNISFFPSDAVDFFMRSIDKIKKDRERETHTGRVDFLQMMI
ESQKSDSNGSSDAKHSYKALSDIEVLSQAFIFIFAGYEPTSNTLGYLAYQLALHPDVQ
QKVVNEIDTILPNKAPLTYEAIMQLEYLDMAVNETLRLYPLGGRLERTCKRDVEINGV
TIPKGTIVIIPPYTLHRSPEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIG
MRFALLTLKVAITAVLQHFTFQVCKETQIPLKLQSLGLTTPEKPIVLKLVPRTNTAKA

CYP3A37     Meleagris gallopavo (turkey) 
            DQ450083
            Shirley Yip, Roger Coulombe, Jr.
            Submitted to nomenclature committee Jan. 20, 2006
            Clone name CYP3A-F4
            92% to chicken 3A37 probable ortholog
MNLLPFFSIETWILLLIFVALLIAYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLEFDTECFKKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRVDLAGELRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKHFGEMLVKNV
QKRVEKDSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
LFILAFVCPFLTPLMAKMNVSFFPSDAVDFFLRSIDKIKKDREKETHKGRVDFLQMMI
ESQKSDSDGKNSHKALSDIEVLSQAFIFIFAGYEPTSNTLCYLAYLLALHPDVQQKVV
NEIDTILPNKAPLTYEAIMQLDYLDMAVNETLRLYPLGGRIERTCKKDVEINGVTIPK
ETIVVIPPYTLHRNSEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIGMRFA
LLTLKVAITSILQHFTFQVCKETQIPLKLLSMGLMTPEKPIILKLVPRTNNAKA

CYP3A37     Struthio camelus (ostrich)
            No accesion number
            Yusuke Kawai
            Submitted to nomenclature committee May 2, 2013
            79% to CYP3A37 chicken
            79% to CYP2AF1 Meleagris gallopavo (turkey)

CYP3A37     Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_1137:6582-24650, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca4.
            69% to CYP3A37 chick (ortholog), 64% to CYP3A113, 
            63% to CYP3A98 dog, 63% to 3A80 chicken
MELLPSFSIETWSFLVVLLGLLLLYGIWPFGVFGKLGIPGPRPWPFLGTLLQYRKGFVKFDSWCFQKYGRIWGIYDGRQPVM
AILDPAIIKTVLVKECYTTFTNRRNFGATGVLKSAISLAEDEHWKRVRTVLSPTFTSGKLKEMFPIIKHYGEALMRNVQKKV
DMDEPLVVKDVFGAYAMDVVTSTSFGVNIDSMNNPKDPFVKEIQKLTKFRSFDPRIILLFTFPILRTVFEALNIQIFSAEAV
DFFTRSFAKMKAGRAGETKEGRVDFLQLMIDSQTSNGHHQSNGIDHTYKGLTDDEILAQAFIFVFAGYEPTSNSLGYMAYML
ATHPDVQQKLQDEIDSVLPNKAPLTYDAIMQLEYLDMVLNETQRLYPLGGRIERVCKKDVEINGVTIPKGVVVMIPPYNLHR
DQEYWPEPEEFRPERFSKENKESVDPYTYLPFGAGPRNCIGMRFALVTMKVAITILLQHFSFRVCKETPIPLELSSQAFLVP
EKPIVLKLVRRNNLQ

CYP3A38     Medaka (fish)
            no accession number
            Seth Kullman
            submitted to nomenclature committee 11/6/98
            72% identical to CYP3A27 trout

CYP3A39v1   Sus scrofa (pig)
            GenEMBL AF109068, NM_214422
            Schuetz,E., Andag,R., Wieland,E. and Oellerich,M.
            Porcine Cytochrome-P450 with high protein homology to human CYP3A4
            (Nifedipine oxidase J04449)
            Unpublished
            88% identical to 3A29
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQDPFVENSKKLLKFSFFSP
LFLSIIFFPFLTPILEVLNVTLFPKSVVNFFMRSIKRMKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKGLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHGVSVPKGT
VMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGTVGGA

CYP3A39v2   Sus scrofa (pig)
            GenEMBL AB052263 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            3 amino acid diffs with 3A39v1, 1 aa diff with 3A39v3
            clone name 3Ac13

CYP3A39v2   Sus scrofa (pig)
            Be aware that there is a sequence in Genbank called CYP3A39v2
            With accession number EF625354
            This sequence is really CYP3A46v3 
            with one amino acid difference to CYP3A46

CYP3A39v3   Sus scrofa (pig)
            GenEMBL AB052264 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            1 amino acid diff with 3A39v2, 2 aa diffs with 3A39v1
            clone name 3Ac19

CYP3A39v4   Sus scrofa (pig)
            GenEMBL AB052265 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            4 aa diffs with 3A39v3, 6 aa diffs with 3A39v1
            clone name 3Ac32

CYP3A39v5  Sus scrofa (miniature pig) 
           no accession number
           Haitao Shang
           Submitted to nomenclature committee May 23, 2007
           partial sequence with frameshifts before I-helix
           95% to CYP39A1v1 NM_214422 
           only 2 aa diffs in first 193 aa

CYP3A40     medaka
            no accession number
            Seth Kullman
            submitted to nomenclature committee 1/12/99
            90% identical to CYP3A38 trout

Cyp3a41     mouse 
            GenEMBL NM_017396 AB033414
            Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
            Honma,R. and Nemoto,N.A novel female-specific member of the CYP3A gene 
            subfamily in the mouse liver
            Arch. Biochem. Biophys. 377 (1), 153-162 (2000)            
            91% identical to 3a11 87% identical to 3a16 69% to 3a25 and 
            68% to 3a13 90% to 3a44
            submitted to nomenclature committee 6/1/99
MNLFSALSLDTWVLLAIILVLLYR
YGTRTHGLFKKQGIPGPTPLPFLGTVLNYYK
GLWKFDMECYEKYGKTWG
LFDGQMPLFVITDPEMIKNVLVKECFSVFTNRR
EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKE
MFPVIEQYGDILVKYLMQEAEKGKPVTMKD
VLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFS
VVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQK
HRVDFLQLMMNAHNNSKDKDSHK
ALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNK
APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPER
FSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQ
IPLKLSRQGLLQPEKPIVLKVVPRDVVITGA

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Cyp3a41-de1b2b mouse
           GenEMBL NT_039318 
           exon 1,2 - strand 
           y in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
           possible alternative exons for 3a41
1729618 MNLFSALSLDTLVLLAIILVLLYR 1729547
1727537 YGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK 1727445

Note: These two exons are identical to 3A16 exons 1 and 2
This sequence is at the edge of the genome sequence gap between 3a41 and 3a44
The NT_039318 sequence has been removed in the new mouse genome assembly,
So these sequences could be due to errors in assembly.

Cyp3a41-de12c mouse
           GenEMBL NT_039318 - strand
           detritus exon 12 
           x in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1739825 SNGPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1739715

note this seq is nearly identical to Cyp3a16-de12b
it is in a region of some uncertainty, and may be due to errors in assembly.

CYP3A42     Python regius (ball python or royal python, African snake) 
            GenEMBL AF319041
            Mette Liljenberg, Tove Hegelund-Myrback and Malin Celander
            Submitted to nomenclature committee Oct 22, 1999
            59% to mouse 3a

CYP3A43     human
            GenEMBL AC011904 8902-46787 13 exons
            Gene assembled from genomic sequence by Henry Strobel 
            and David Nelson on Dec 11, 1999
            intron exon boundaries defined by comparison to rat 3A9
            and human 3A sequences.  GT AG pairs found for all introns
            ESTs AA417369 zu08d03.s1 AA416822 zu08d03.r1 Soares testis
            Opposite ends of same clone
            67% identical to rat 3A9

Assembled gene * = intron exon boundary ** = EST support for this boundary

MDLIPNFAMETWVLVATSLVLLYI*
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR*
GLWNFDRECNEKYGEMWG*
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM*
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE*
MVPIISQCGDMLVRSLRQEAENSKSINLKE*
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI* 
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK*
HRVDFFQQMIDSQNSKETKSHK*
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK**
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE**
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ**
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP*

coding region 504 amino acids

exon 1 8902-8972
exon 2 17239-17332
exon 3 19906-19958
exon 4 24929-25028
exon 5 28274-28387
exon 6 28952-29040
exon 7 30332-30480
exon 8 36377-36504
exon 9 37619-37685
exon 10 40616-40776
exon 11 42399-42625
exon 12 44323-44485
exon 13 46692-46787

CYP3A43-de1b human = CYP3A137P (name conflict with carp)
            GenEMBL NT_007933.10|Hs7_8090  + strand alternate exon 1
            24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214

CYP3A43-de4c6c  human = CYP3A52P
            GenEMBL NT_007933.12|Hs7_8090 
            chromosome 7 genomic contig
            Length = 64383103
            Last exon of 3A43 in build 33 of human genome
            24697113 IPLKLDNLPILQPEKPIVLKVHLRDGITSGP* 24697208
            CYP3A43-de4c6c = s in Fig. 3A, 
            old names = 3A52P, 3A53P 
            Exon 4 pseudogene fragment
            24701048 MIKTVLVKECYSVFPNWR 24701101
            exon 6 pseudogene fragment
            24703375 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 24703464

CYP3A43     Pan troglodytes (chimp)
            XM_527830.2
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWNFDRECNEKYGEMWELYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRLPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPQNCIGMRFALT
NIKLGVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP

CYP3A43     Macaca fasicularis (cynomolgus monkey)
            DQ074796
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP3A43
            96% to human CYP3A43 only 75% to 3A4, 3A5
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKVGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKATVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQIPLKLNNLPILQPEKPIVLKVHLRDGITSGP

CYP3A43     Macaca mulatta (rhesus monkey)
            XM_001098213.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            mmul3a43
            96% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETSLHHSLSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQLPLKLNNLPILQPENPIVLKVHLRDGITSGP

CYP3A43     Macaca mulatta (rhesus monkey)
            NP_001121102
            UCSC Browser chr3:47099079-47140713 (+) strand

CYP3A43-de1b     Macaca mulatta (rhesus monkey)
            UCSC Browser chr3: 47090970-47091041 (+) strand
            Ortholog to human CYP3A43-de1b, 4 aa diffs
            pseudogene exon 1 between 3A4 and 3A43 (+)
            8 kb upstream of CYP3A43
47090970 MDLIPNFAMDMWVLPATRLVLLYL (2) 47091041

CYP3A43-de4c6c    Macaca mulatta (rhesus monkey)
            UCSC Browser chr3: 47144523-47146892 (+) strand
            ortholog to the human pseuddogene, 1 amino acid difference
47144523 MIKTVLVKECFSVFPNWR 47144576
47146803 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 47146892

CYP3A43     Pongo pygmaeus (orangutan)
            EF589793.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a43
            98% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RQEAENSKSINLKDFFGAYAMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLLISLFPFLTPVFEALNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVLIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP

Cyp3a44     mouse
            GenEMBL AB039380
            Tsutomu Sakuma
            Submitted to nomenclature committee 2/29/2000
            This sequence differs from 3a11, 3a13, 3a16, 3a25 and 3a41 (90%)

Cyp3a44     mouse
            GenEMBL AC111090.20 genomic clone
            This clone contains part of 3a25, Cyp3a25-de8b9b12b, 3a11, 
            A pseudogene between 3a11 and 3a44, and most of 3a44
178101 MNLFSALSLDTLVLLAIILVLLYR 178172
180134 YGTRTHGLFKKQGIPGPKPLPFLGTVLNYYT 180226
182562 GIWKFDMECYEKYGKTWG 182615
184471 LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRR 184569
188874 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 188987
189067 MFPVIEQYGDILVKYLRQEAEKGMPVAMKD 189156
189424 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSV 189570
192147 VLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQK 192275
193171 HRVDFLQLMMNSHNNSKDKDSHK 193239
195368 AFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNK 195529
204141 ATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPS 204308
204309 YALHHDPQHWPDPEEF 204356 (runs off end, last section from AB039380)
       QPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLA
       VTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITGA

Cyp3a44-de9b10b11b12b     mouse
           GenEMBL AC111090.20 genomic clone
           This seq is between 3a11 and 3a44. It is 13kb from 3a44, 20kb from 3a11
           The exon 12 part used to be called Cyp3a11-de12b
           The exon 9 part is identical to w in Figure 3B Nelson et al.     
           Pharmacogenetics 14, 1-18 2004.
165130 HQVDFLHLMINAHDKTKDKETHK 165062
160280 ALSNMEITTQSIMFIFASYKPTSSTLSFALCSLVTHHAS*KKLQENDKTLTNK 160122
156349 VELESLDMVLNETLRLYPTADRLVKVYKKDVELNDAFILKWSLEIVSCYSLCHDPQNWPEHKEFCPE 156149
148858 RFSMENKGSIDPYG 148817
148815 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 148690

Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled.  The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11.  It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].

Note: the following sequences (4 exons) lie between 3a41b and 3a44
Cyp3a41b-de12b
(-)15459 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQ 15298
3 aa diffs to Cyp3a-se5[12]

Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]

CYP3A45     Oncorhynchus mykiss (rainbow trout)
            No accession number
            Su-Jun Lee, Don R. Buhler 
            96% to 3A27 but different 3 prime and 5 prime ends

CYP3A46   Sus scrofa (miniature pig) 
          EF625347
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007 (partial)
          Complete sequence in Genbank 03-SEP-2008
          92% to 3A39v1, 76% to human 3A4 and 3A5
          formerly CYP3A88. Name changed to CYP3A46 after whole sequence known
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRSAVSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNVDSLNNPQDPFVENSRKLLKFSFFSP
FFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSIKRMKESRLKDTQKHRVDLLQLMI
NSQNSKEMDAHKGLSNEELVAQGVIFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPNKAPPTYDGLAQMEYLDMVVNESLRIFPVTPRLERSCKKDVEIHGVFVPKGT
VMMVPIFALHRAPELWPEPEEFRPERFSKKNKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCRETQIPLKISSQGLIQPEKPIVLMVVPRDGTTSGA

CYP3A46   Sus scrofa (miniature pig) 
          3 aa diffs to CB479861.1 EST, probably the same seq.
          F22946.1 extends seq toward N-term.
          AJ959509.1 overlaps F22946 with 1 aa diff in 42
          Be aware this may be a hybrid of two or more gene sequences.
          BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
          DB799225.1
          92% to 3A39v1
          Formerly CYP3A88. Name changed to CYP3A46
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*

CYP3A46v1   Sus scrofa (pig)
            GenEMBL AB052266 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            13 diffs with 3A39v1, 9 diffs with 3A46v2 all in the last 43 aa
            clone name 3Ac4
            two amino acid differences with full length CYP3A46

CYP3A46v2x  Sus scrofa (pig)
            GenEMBL AB052267 
            Misaki Kojima
            Submitted to nomenclature committee Oct. 27, 2000
            9 diffs with 3A46v1 all in the last 43 aa, 20 diffs with 3A39v1
            clone name 3Ac28
            the last 61 amino acids are identical to CYP3A22v2
            this sequence appears to be a hybrid of CYP3A46 and CYP3A22v2

CYP3A46v3   Sus scrofa (pig)
            EF625354
            Partial sequence with 1 amino acid diff to CYP3A46

CYP3A47X    Fugu rubripes (pufferfish)
            No accession number
            Scaffold 600
            Renamed CYP3D1
      MNYLPLFALETWILLITFTCLFVM (2)
      YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
      NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
      IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
      FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQ (1)
      GCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
      EFDFLQHMISTQKNDGIYAVTS
  (1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
      LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
      FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
      IPFKMDPNTFVGPINPIKLRVVRR*

CYP3A48     Fugu rubripes (pufferfish)
            No accession number
            Scaffold 1124a
44660 MDLLLNFSIETWTLLTLVFTLIIV 44589 (2)
44089 YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR 43997 (0)
43888 GVHHFDEECYKKYGKVWG 43835 (2)
43728 LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR 43630 (0)
43549 DLGLNGPLRDAVSVAEDEQWKRIRGILSPSFTSGRLKE 43436 (0)
43350 MYTIMLQHSKNLLNFLHKKVEADEVIDVKD 43261 (2)
42808 VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV 42662 (1)
42612 VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK 42452 (0)
42378 SRVDFMQLMVNAQMQEGNEEGSSQK 42310 (1)
42109 GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK 41948 (0)
41869 VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEI 41747
41746 NGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER 41648 (2)
41162 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD 41001 (0)
40889 IPMVLNTEGLVAPKNPIKLKLKPRAVSS* 40803

CYP3A48     Fugu rubripes (pufferfish) 
            UCSC browser chrUn:165976318-165979993 (+) strand
            Two genes separated by a seq gap
            89% to CYP3A49 fugu, 82% to CYP3A49 Tetraodon
MDLLLNFSIETWTLLTLIFTLIIV (2)
YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR (0)
GIHHFDEECYKKYGKVWG (2)
LYDGRQPLMCIMDTGMIKTVLVKECYSNFTNRR (0)
DLGVNGPLSDAVSVAEDEQWKRIRGILSPSFTSGRLKE (0)
MYTIMLQHSKNLLNFLNKKVEADEVIDVKD (2)
VFGPYSMDVVTSTAFSVDIDSINNPSDPFVANIKEMTQFSFLNPLVVLT (1)
VLFPFLVPIFKKMNVSTFPAHVIDFFFNFLRQIKSDRNKDKKK (0)
SRVDFMQLMVNAQMQEGNEEGSSQK (1)
GLTDNEILAQAMIFIFGGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK (0)
VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEINGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER (2)
FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD (0)
IPMVLNTEGLVAPKNPIKLKLKPRAVSS*

Note: CYP3A48 is missing in the Tetraodon genome assembly but it is found in GenPept

CYP3A48     Tetraodon nigroviridis (freshwater puffer)
            CAF91666 GenPept
            85% to 3A48 full (probable ortholog), 87% to 3A49 C-term fragment,
MDLLPDFSIETWTLIVLVFTLITVYGYAPYGFFKNLGIHGPKPWPFIGTFLNYRKGVHHFDQECYKKYGKVWSLFDGRQPLM
CIMDTLMIKTILIKECYSNFTNRRDLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKEMYTIMLQHPQNLINLLQKKV
KADDVIDVKDVFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILVVLFPFTQTIFDKMDVSLFPGHVL
DFFYNFLRQIKSDRSKEKKKSRVDFMQLMVNAHMTEDNEKDSSLKGLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNP
DIQKKLQEEIDKTFPGKVRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPAL
WPEPEAFKPERFSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETEIPMVLGSEGFVTPKTPI
KLKLKPRTSS

CYP3A48     Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrXII:12771920-12775348, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            gac2628
            70% to 3A48 Fugu, 72% to tetraodon 3A48,
MGFLPELSIQTWTLIVFLVTLITVYGYAPYGFFKKLGIPGPRPLPFIGTFLEYRKGIHNFDTECYEKYGKVWGIYDGRVPIL
VTMDTAMIKSILVKECYSNFTNRRDFGLNGALRDAITVVEDEEWKRIRSILSPSFTSGRLKEMYSIMLQHSGNLIKSLHKKA
EAGEVVDVKDIFGPYSMDVVASTAFSVDIDSINNPSDPFVANIRKLVKFTFLTPLFLLLVLFPFLEPMLDKMNVTLFPAELL
DFFYSFLKTIKSDRSKNEHKNRVDIMQLMVDSQMSETTKEDPSAHKGLSDSEILSQAMIFIFAGYETSSGTLGFLAYNLATN
PDIQKTLQEEIDETFPNKARPTYDALMQMEYLDMVLNESMRLYPSGNRLDRVSKSSVEIEGVTIPKGTVVMIPVYTLHREPT
LWPEPDDFKPERFSKENKDSIDPYSYLPFGAGPRNCIGMRFALLMMKLSVVEILQNFSFVTCKETQIPLELSTDGFTTPKDS
INLKLEPRGAHC

CYP3A49     Fugu rubripes (pufferfish)
            UCSC browser chrUn:165961462-165963240 (+) strand, 
            exons 1-6 followed by a gap
            at 204-207K on scaffold 35 95% to 3A48
            FS:S000035 Scaffold_35
            SLC6A8 PCTK1 DDX20 KCND2 CYP3A50P CYP3A49 CYP3A48 CAPZA1 APEH WNT5A
            CAAB01000035.1 has this sequence from 204598-207532 (-) strand
MDLLPNFSIETWTLIALVITLITV (2)
YGYAPYGFFKKVGISGPKPWPFIGTFLNYKK (0)
GVHHFDEECYKKYGKVWG (2)
LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR (0)
DLGLNGPLRDAVSVTEDEQWKRIRGILSPSFTSGRLKE (0)
MYTIMLQHSKNLLNFLHKKVEADEVIDVKD (2)
VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV (1?)
VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK (0)
SRVDFMQLMVNAQMQEGNEEGSSQK (1)
GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK (0)
VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMTKTSVEINGLTIPKGTVVAIPVYALQRDPVLWPEPEAFKPER (2)
FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVTCPETD (0)
IPMVLGNEGFVTPKNPIKLKLKLRDVSN

CYP3A49     Tetraodon nigroviridis (freshwater puffer)
            87% to fugu CYP3A49, 82% to adjacent CYP3Axx gene
            SLC6A8 PCTK1 DDX20 CYP3A50P CYP3A49 APEH TLR9
MDLLPDFSIETWTLIVLVFTLITV (2)
YGYAPYGFFKNLGIHGPKPWPFIGTFLNYRK (0)
GVHHFDQECYKKYGKVWS (2)
LFDGRQPLMCIMDTLMIKTILIKECYSNFTNRR (0)
DLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKE (0)
MYTIMLQHPQNLINLLQKKVKADDVIDVKD (2)
VFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILV (1)
VLFPFTQTIFDKMDVSLFPGHVLDFFYNFLRQIKSDRSKEKKK (0)
SRVDFMQLMVNAHMTEDNEKDSSLK (1)
GLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNPDIQKKLQEEIDKTFPGK (0)
VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPALWPEPEAFKPER (2)
FSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETE (0)
IPMVLGSEGFVTPKTPIKLKLKPRTSS*

CYP3A50     Fugu rubripes (pufferfish)
            chrUn:165954227-165957711 (+) strand
            at 212-211K on scaffold 35
            the improved version of this seq does not look like a pseudogene
MNFLPDFFLNTWTFLILVIVLSTT (2)
IKRVGIRGPTPWAPLIGDIFYSTRRG (1)
KCCKRYGKVWG (2)
LYEGRIPVMFIVDTAMIKTVFVKEGYSVFLNRK (0)
SIGPNGILSTGLPFLRDDNWKRVHKIVSPAFSSGRMKD (0)
MFSIMLQHSNILM 
FSIDIESLNNPSSPFLHYLQEVSKYNYMNLWRLLG (1)
AIFPFLTPLMDKMNITVNSSEALQFFISVIKKIKEERKNNPK (0)
DRVDFMQLMLNAQAPDGSNKDCDSA (1)
GLSDEEIMVQALIFALVGNGNMAYLVAFTAYNLAVHPQTQTRLQAEIDRTFPGKVSPN (1)
SYEELLQLKYLDMVVTETSRLYPLGNRIERVAKSTVEVSG
VIIPEGVAVAVPIYTLHRDPTVWPDPDSFKPER (2)
FSKDNRDNIDPYGLL 
GPRSCTGTRMSMLVVKLTLVEILQHFSFVACKETM (0)
IPMVLDDNGFVHPKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN*

CYP3A50P   Tetraodon nigroviridis (freshwater puffer)
           ortholog of fugu CYP3A50P pseudogene upstream of CYP3A49
           58% to CYP3A49 Tetraodon, 69% to CYP3A50P fugu
MGFFPDLCTETWTLLALVFVL
YTLFKRLGIKGPMPWPFIG
VGNNNMATSVAFAAYNLALHPEVQKKLRAEIDRTFSGK (0)
CRPTYEKLVQMKYLEMVIKETLRLYPIGNRIERVAKSNVEVSGVIIPKGMVVATPIHTLQRDPDVWPDPDSFKPER (2)
FNNDSIDPYGFLTFGTGPRACIGMRLSILIMKLALVEILQHFSFASCKETD (0)
IPLELARNGFVLPKKPIML &
KLEPREPAA*

CYP3A51P    human = CYP3A5-de13c
            GenEMBL NT_033964.1|Hs7_34119 
            chromosome 7 detritus exon 13 upstream of 3A5
            old name = 3A51P, note: this name is being used by the HGNC
            254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
            because the HGNC has strict rules for gene names,
            The old names (CYP3A51P, etc.) are being used by the HGNC
            These will be synonyms. 

CYP3A52P   human = CYP3A43-de4c6c
           AC011904 part of exon 4 downstream of CYP3A43, 88% to 3A4 
           MIKTVLVKECYSVFPNWR
           67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6

CYP3A53PX  human merged with CYP3A52P
           NT_033964.1|Hs7_34119 Homo sapiens chromosome 7 
           detritus exon 6 downstream of 3A43
           new name = CYP3A43-de4c6c
           67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6

CYP3A54P   human = 3A-se1[2]
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 2
           2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548

CYP3A55P   human = 3A-se2[5]
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 5
           2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579

CYP3A56    Fundulus heteroclitus (killifish)
           AY143428
           Tove Hegelund and Malin Celander
           64% to 3A48 Fugu 99% to 3A30
           submitted to nomenclature committee 6/20/02
MGYFYLTAETWTLLVAFVTLLLIYAYWPYGTFKRLGISGPKPVP
FFGTMLHYRRGFFTFDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFT
NRRNFHLNGPLYDALSVAEDDQWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMK
KKADKDEPLDLKEFFGSYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPL
FLAVAFFPFLGPILEKFELSFFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMID
SQKNSGAQQDKSLTDHEILSQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEI
DATFPNKAPVHYQPLMEMEYLDCVINESLRLFPIAARLERVAKAAVEINGIVIPKDMV
VMIPTWPLHRDPEIWPEPEAFKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVL
IKLAVVEILQQYSFSVCKETEVPFEMDIQGLLAPKRPIQLKLVPRS

Cyp3a57    mouse 
           GenEMBl AC115895.3, XM_144630 XP_144630 Genbank assembly incorrect
           AC115895.4 13 exons, exon 9 is backwards
           NT_039318
MELIPNLSIQTWVLLVTSLVFFYI
YGTYSHGLFKKLGIPGPKPLPLFGNIINYLD
GMWKFDDDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
PFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKE
MFPIMRQYGDILVRNLRREEEKEEPINMK
DIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLS 
VVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQK
NRVDFLQLMMNTQNSKGQESLK
ALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK
APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQ
IPVKISRQPIFRPEKPIILKFVSRDKPRTGP

Cyp3a58-ps mouse
           GenEMBL NT_039318 + strand 
           Between 3a16 and 3a41
           Note this seq is 86% identical to Cyp3a44-de9b10b11b12b
           [3a16, 3a58-ps, 3a41] is probably a tandem duplication of 
           [3a44, 3a44-de9b10b11b12b, 3a11]
           exon 8
1629527 PVFFSFLNPI*EMLKISVFPKDSIAFFKKKLWTEQRKTSWILSKR 1629661
exon 9 new fron UCSC Browser
26701 HQVDFLHLMINAHDNTKDNESHK 26769
           exon 10
1651425 ALSNIEITTQSIMFIFASYEPTSSTLSFVLYLLVTHHDIWKKLQENDRALPNK 1651583
           exon 11
1660734 VEMEYLDMVLNETLRLYPTADRFVKVYKKDVELNDAFILKWS 1660859
           exon 12
1669382 FSMENKGSIDPYX 1669417
1669422 YMPFGNGPRNCISMRFAVMSMKFALTKVLQNCYLHPCKETQ 1669544


Cyp3a59    mouse
           GenEMBL NW_000248.1|Mm5_WIFeb01_96 gene interrupted by gaps 
           AC113316.2
           old temp name = cyp3agg 
           93% to Cyp3a25
LLLYRYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFD
GMWKFDEDCYKKYGKIWG 
FYVGPKPILAIMDPEIIKIVLVKECYSVFTNR 
RLLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPINMKE
IFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLS
VVLFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKERLASKQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLH
RNPEYWPEPQEFCPG
RFSKENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQ
IPLKISREPVFQPEKPIILKVVSRDKPRT

Cyp3a59-de11b mouse
           GenEMBL NT_039324.1 - strand 
           detritus exon 11
           p in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
191646 VSFLLVTLVEIEYLDILVT*ILRLNPIGNRLESVSKK 191536
191539 EMFEVFIPKGTRVTVLTFALH*DEQYWPEXXXXXXXX 191453

Cyp3a60-ps  mouse
           GenEMBL NT_039324.1 + strand 
           Cyp3a ps about 60% to 3A25
exon 2
331420 PVRLPVIGLLLSLYN 331464
exon 5
338061 KKVITISEEDERKRL*TLLSPTFIS 338135
exon 6
338410 MFPIIGQYGETLVK  338451
338451 KKRKGEPINMKE 338486
exon 7
338734 SMDVVTGTLFGVNVDSLTNSSDPCAESQGDLNKFEFS*PTSLG 338862
exon 8
341951 VAMLPFLTTIYKILSISIFP 342010
342409 KYMKQSRLDTNQK 342447

Cyp3a61-ps  mouse
           GenEMBL NT_039315.1, also on NW_000239.1
           Old temp name = Cyp3ayyp 
           Exons 10,11,12,13 
1115767 ALSDLEIVAQSISFIFAGYETTSNTLSYIMYTLATHPDVQKKLQQEIDAILPNK 1115606
1113252 APATYNDLEKIEYLDMVINETLRLYPIGARISRLSKKDAEINGVFIPQNTEVAVPVF 1113082
1109396 FSQENKDRINPYVYMPFGNGPRNCLGMRFALINMKLAVVKILQNFSVQPCEDTE (0) 1109235
1108058 IPLKLSKKLILSPEKPIVLKVTARDGAINEG* 7963

Cyp3a61-de11b mouse
           GenEMBL NT_039315.1, also on NW_000239.1
           Old temp name = Cyp3azzp 
           detritus exon 11 next to Cyp3a61-ps
           n in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1136553 APATYNGLVKIRYLDMVINETLRLYPVGVRISRLSKKDAEINGVLTPQNTK
        VDVALFVLH*DPEYWPXXXXXXXXX 1136353

CYP3A62     rat
            GenEMBL AB084894 
            Matsubara T, Kim H. J, Miyata M, Shimada M, Nagata K and Yamazoe Y.
            Isolation and characterization of a novel rat CYP3A, CYP3AL1, 
            predominantly expressed in intestinal tract  Unpublished 2003
            80% to CYP3A9, 78% to Cyp3a13
MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD

Cyp3a62-de11b     rat
        GenEMBL NW_001084671.1 11932479-11932637
11932637  KKNQDSISPYVYLPFGFRPRNCIGMRFALMNMKVALVRVLQNFSFQPCKEIQL  11932479

Cyp3a63-ps  mouse
The following seqs are part of one pseudogene 3a63-ps
           GenEMBL NT_045749.1|MmUn_45789_30 
           3a exon 2 same as 3a63-ps
396 YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK 304
           NT_071156.1|MmUn_71196_30 
           exons 5,6,7 same as 3a63-ps
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
           old name = Cyp3a44-se3[10] NW_037585.1|MmUn_WIFeb01_5425 
           3 diffs to 3a44
           same as CYP3A63-ps
649 AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK 
           old temp name = Cyp3attp 
           80% to 3a11 NW_008810.1|MmUn_WIFeb01_17679 
           one frameshift and small deletion same as CYP3a63-ps exon 11
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPS
YALHHHWPESEEFQPER
           Old name = CYP3A44-se1[12] NW_005077.1|MmUn_WIFeb01_14285 
           2 diffs with CYP3a44
1231 RFSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ 1067

Cyp3a63-ps AC114427.2 
This sequence is between 3a41a and 3a41b
Note: Cyp3a44-de12c has only one aa diff to this seq
63090 MNLFSALSLDTWILLAIILVLLYR 63019  probable beginning of pseudogene
YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK
GFWKFDMECYEKYGKTWG
LFDGQMPLFVITDP*MIKNVLVKECFSVFTNRR 
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
HRVDFLQLMMNAHNNSKDKDSHK 
AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPSYALHH(fs)HWPESEEFQPER
FSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ
IPLKLSRQGILQPEKPIVLKVVPRDAVITGA

The following sequences are bewtween 3a41a and 3a63-ps
(-)11231 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQV 11067
two sites have exact matches 145849323- 145849487 between 3a41a and 3a63-ps and 
146039664- 146039828 between 3a41b and 3a44
3 aa diffs (94%) to Cyp3a-se5[12] probably a poor quality seq match

Cyp3a-se12[8:9:10]
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
IVERTKENCLDSKQK
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10] 
(+)31398 SPVQMEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10

The following sequences are bewtween 3a63-ps and 3a41b
Cyp3a-se13[9]
76087 HQVDFLHLMINAHDKTKDKETHK 
identical to exon 9 of Cyp3a44-de9b10b11b12b includes old frag w from map

128725 RFSMENKGSIDPY 128763
128769 GPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQV 128876 = Cyp3a-se10[12]

CYP3A64X    Macaca mulatta (rhesus monkey)
            Analysis of the genomic DNA shows this gene is syntenic with 
            human CYP3A4 so it has been renamed CYP3A4
            No accession number
            Tom Rushmore, Merck & Co. Inc.
            Submitted to nomenclature committee 6/30/2003
            92% to CYP3A4

CYP3A65     Danio rerio (zebrafish)
            No accession number
            Hua-Bin Tseng, Hou-Chu Yin, Chin-Hwa Hu, 
            Jun-Lan Wang-Buhler, and Donald R. Buhler
            Submitted to nomenclature committee 10/10/2003
            71% to 3A27 trout, 71% to 3A45 trout, 69% to 3A40 Oryzias, 
            69% to 3A30 Fundulus, 69% to 3A56 fundulus,
            56% to 3A37 chicken, 58% to 3A48 fugu  59% to 3A49 fugu, 45% to 3B2

CYP3A66X    Macaca mulatta (rhesus monkey)
            No accession number
            Brian A. Carr, Merck & Co. Inc.
            Submitted to nomenclature committee 4/22/2004
            91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
            name has been changed to indicate orthology = CYP3A5

CYP3A67     Pan troglodytes (chimpanzee)
            EF507836
            Eric Williams, Henry Strobel
            Recent gene duplication of CYP3A7

CYP3A67     Pan troglodytes (chimpanzee)
            NM_001093774
MDLIPNLAVETWLLLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFVGNVWSFRKGFWTFDMECYKKYRKVWGFYDGLQPVLAITDPDMIKTVLVKECYSVF
TNRRPLGPVGFMKSAISRAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREADTGMPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNSLDP
FILSIKIFPFLTPILEALNITVFPRKVTSFLTKSVKRIKEGRLKETQKHRVDFLQLMI
DSQNSKDMESHKALSDLELVAQSIVFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKFALVRVLQNFSFKPCKETQIPLKLRFGGLLRTEKPIVLMAESRDETVSGA

CYP3A67     Pongo pygmaeus (orangutan)
            EF589796.1
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ppy3a67
            96% to 3A67 chimp
MDLIPNLAVETWLLLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFVGNALSFHKGFWTFDMECYKKYRKVWGFYDGLQPVLAITDPDMIKTVLVKECYSVF
TNRRPLGPVGFMKSAISRAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYADVLVRNL
RREAETGKPVTLKDFFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNSLDP
LTLSIKIFPFLIPILEALNVTVFPREVTSFLTKSVKRIKEGRLKETQKHRVDFLQLMI
DSQNLKDTESHKALSDLELVAQSIVFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWIEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKFALVRVLQNFSFKPCKETQIPLKLRFGGLLRTEKPIVLMAESRDETVSGA

CYP3A68  Large mouth bass
         DQ786406
         David Barber
         Submitted to nomenclature committee 5/21/04
         Clone name CYP3A-a
         74% to CYP3A27 trout
MGYFFFFSAETWTLLVALITLIFVYVCWPFGTFKKMGVPGPRPI
PFFGTMLAYKKGFMHFDSECFKKYGKTWGIFDGRQPVLCITDPAMIKTVLIKECYSLF
TNRRNFRLNGELYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLISSM
KKTADKDEPLELKEFFGPYGMDVVTSTAFSVDIDSLNNPTDPFVANIKKMLKFDLFNP
IFLFIAFFPFMAPILEKLEFSFFPKSVLDFFYAALKKIKANRETTKLKNRVDFLQLMI
NSQKNNDLSKVENDKGLNDHEILSQAMIFLFAGYETTSSSLTFLAYNLARNPHVMKRL
QEEVDATFPNKAPVEYQALMQMEYLDSVVNESLRLYPIAPRLERVAKATVEINGLVIP
KGMVVMVPTWPLHRDPDLWPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRF
ALVLMKLAVVEILQTYSFSVCKETEIPIELDIQGLISPKRPIKLKLVPRSEPSN

CYP3A69X  Large mouth bass
         DQ786407
         David Barber
         Submitted to nomenclature committee 5/21/04
         Clone name CYP3A-b
         64% to CYP3A47 Fugu
         note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR

CYP3A70  Macropus giganteus (Eastern grey kangaroo)
         DQ888646
         Ross McKinnon
         Submitted to nomenclature committee Oct. 25, 2004
         65% to CYP3A4
         NOTE: THIS SEQ IS MOST LIKE RAT 3A9 compared to other rat 3As
         Therefore the 3A9 seq may be the oldest of the cluster in rats
         3A9 is orthologous to 3a13 in mouse.  Both sequences are on the 
         outside edge of the cluster.  
MNIIPSLSAGTWALLVLFLTLLFLYGTWTHKLFKDLGIPGPAPL
PFFGTVLSYRKGFTDFDMTCFKKYGKTWGFFDGRKPVLSIMDPETIKLVLVKECFSVF
TNRRSFGPAGIMESAISIAEDDQWKRIRTILSPTFTSGKLKEMFPIIKQYGDVLVKNM
GKEAEKSKPVSLKDIFGAYSMDVITSTSFGVKTDSLNNQDDPFVREIRKLIKFNFLDP
LLLTVSIFPFVIPLLKKMDVTIFPKETLDFLTKSIKKIKEDRKKNSQKNRVDFLQLMM
DSQTSKNSEMHSQKDLSDDEILAQSVIFIFAGYETTSSVLCFLFYHLATHPEIQQKLQ
GEIDAVLPNKEAVTYDALVQMEYLDMVIHEILRLYPIAGRIERVAKKTVEINGVKIPK
GTVVMVSPFVLHRDPDYWPEPEEFRPERFSKENRESMNPYVYLPFGAGPRNCIGRRFA
LMSMKVATSLVLQEFSFRTCKETQIPVKLNNQPLISPTIPIVLQAVPRSKKGNQH

CYP3A71P  rat
          UCSC Browser chromosome 12
pseudogene 78% to 3A2 
9497641 LFEWHTPVFAITDREMIKNVLVKECFSVFTNWR 9497543 exon 4
9468424 DLGPMGIMNKSIAF*KDEEWKRYRALLSPMFTSGKLKV 9468311
9468234 MFPIIKLYGDILVKYLRQEAEKGKPVSVKE 9468145
9467886 IFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKFLRLDYFDPLFISV 9467737
9464756 GLFPFLKPIYDMLNISVFPKDSIAFFKNFVYSMKESHLDSKQK 9464631
9453844 YQVDFFQLMMNAHNNSSESHK 9453782
9451670 FPALSDIEIIAQSIIFTFGGYDTTSSTLSFVLYSLATHSDVQKKLQEEIDHALPNK 9451503
9449744 ASPTYDIVMEMEYLDMVFNETLRLYPVTGRLHRMCKKDIELDGVFIPKG
        SMVMIPLYPLQHDPQHWPEPEEFRPE 9449520
9447351 RFSKENKCRTGHYVYLPFGNGPRNCLGMRFALMSMKLAVTKVLQNFSFHPCKET 9447190
9444444 QIPLKLSKQVILKPEKPIVLKVVPRDGVING 9444352

CYP3A72    Balaenoptera acutorostrata (Minke whale)
           AB290009
           Iwata Hisato
           submitted to nomenclature committee 1/6/05 
           83% to CYP3A28 cow, 78% to 3A5 human, 75% to 3A5, 
           74% to 3A4, 71% to 3A43
MDLIPSFSVETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILSYRKGLWEFDNRCFKKYGKMWGCYEGQQPLLVITDPDIIKTVLVKECYSVF
TNRRAFGPVGIMKNAISLSEDEQWKRIRTLLSPAFTSGKLKEMFPIISQIGDVLVRNL
KKEAEKGKPISMKDFFGAYSMDVITGIAFGVNIDSLNNPQDPFVEYSKKILKFNLLSP
LLLSIVLFPFLTPVFEALNITLFPKSSLNFLTKSVKRIKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKVLSDTELMAQSIIFIFAGYETTSNSLSFIIYELATHPDVQQKLQEE
IDATFPNKAPPTYEALVQMEYLDMVLNETLRIFPIAGRLERVCKKDVEVNGVFIPKGT
TVVVPLFVLHNDPELWPEPQEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFVIM
NMKLALVRILQNFSFKPCKETQIPLKLLTQGLTQVEKPVVLKVVSRDATISGA

CYP3A73    rat 
           chr12_random_1.5 (from UCSC browser)
           80% to 3A44 81% to 3A41 80% to 3A16 83% to 3A11 
           86% to 3A2 rat 
           this gene lies between Cyp3a85-ps and Cyp3a18
MDLVSALSLETWLLLAIILVLFYR (2)
FGTRTHGIFKKQGIPGPKPLPFLGTVLNYYR (0)
GLWKFDMECYKKCGKIWG (2)
LFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRR (0)
NIGPVGIMSKSISVAKDEEWKRYRAFLSPTFTSGRLKE (0)
MFPIIEHYGDILVKYLKQKVEKGKPLAMKE (2) 
VFGAYSMDVITSTSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSV (1)
VLFPFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQTRLDSKHK (0)
HRVDFLQLMMNAHNNSKDKVSHK (1)
ALSDIEIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNK (0)
APPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDIKLDGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPER (2)
FSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQ (0)
IPLKLSRQRLFGPEKPIVLKVVPRDAVITGA*

CYP3A74     Bos taurus (cow)
            See cattle page for details
MELILSFSTETWVLLATGLVLLYL (2)
YGTYSYGLFKKLGVPGPRPLPYFGNILSYRK (0)
GVCEFNEECFKKYGKIWG (2)
IFEGKQPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDIKD (2)
IFGAYSMDVITSTSFGVNIDSLGNPQDPFVENVKKLLRFSILDPFLLAV(1)
VLFPFLVPILDVLNITIFPKSAVNFFTKSVKRIKESRLKDNQK(0)
PRVDFLQLMINSQNSKETDNHK  (1)
ALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPEPEEFRPER (2)
FSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0)
IPLKISSQGVLRPEKPVVLKVVLRDGTISGA*

CYP3A75     Bos taurus (cow)
            See cattle page for details
MELIPSFSMETWVLLSISLVLLYL
YGTYSHGLFKKLGVPGPRPLPYFGNVLSYRK

VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSV
VLFPFLVPIFEVLNITMFPKSAVNFLAKSVKRIKESRLKDNQK
PRVDFLQLMINSQNSKETDNHK
ALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDVTFPNK
APPTYDVLAQMEYLDMVVNETLRMFPITVRLDRLCKKDVKIHGVSIPKGTTVTVPISVLHRDPQLWPEPEEFRPER
FSKKNKDTISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKSCKETQ
IPLKINSQGLIRPEKPIFLKVVLRDETISGA*

CYP3A76     Bos taurus (cow)
            See cattle page for details
MELIPNFSVETWVLLAISLVLLYL(2)
YGTYSHGLFKKLGVPGPRPLPLFGNVLSYRK (0)
GVCEFDEECFKKYGKMWG (2)
IFEGKHPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPMGVMKNAVSVAEDEQWKRIRTLLSPTITSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDMKE (2)
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILDPFLLSV (1)
VLFPFLIPIFEVLNISIFPKSAVNFLTTSVKKIKESRLKDTQK (0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELMAQSIIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAVRLERFCKKDVEIHGVSIPKGTTVTVPISVLHRDPQLWPELEEFRLER (2)
FSKKNKDSISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKPCKETQ (0)
IPLKIKSQGLLRPEKPIFLKVVLRDETISGA*

CYP3A76-ie6b     Bos taurus (cow)
            See cattle page for details
            extra exon 6 SCAFFOLD300381 other exon 6 at 7654
9898 MFPIIGKYGDVLVRNLRKEAEKGKSVNMKE

CYP3A77    Alligator mississippiensis (alligator)
           GenEMBL AB186129
           Satomi Kohno
           Submitted to nomenclature committee Aug. 18, 2005
           54% to 3A48 Fugu, 57% to 3A27 trout, 61% to 3A5 human
           62% to ball python CYP3A42
           clone name CYP3A_AA

CYP3A78    Phascolarctos cinereus (koala, marsupial)
           No accession number
           Ross McKinnon
           Submitted to nomenclature committee July 29, 2005
           56% TO 3A4 AND 3A5, 77% TO OPOSSUM 3A (UNNAMED)

CYP3A79    Mediterranean sea bass 
           GenEMBL DQ268535 not yet available on Jan 4, 2006
           Pier Giovanni Gervasi
           Submitted to nomenclature committee Dec. 14, 2005

CYP3A80     Gallus gallus (chicken)
            GenEMBL XM_414782
            Note: chicken has two CYP3As about 25kb apart on chr 14
            See CYP3A37
MGLLPDLPPITWLLLAAFLGLLVLYGIWPYQTFKKLGIPGPRPL
PFLGTFLRYRQGLLNFDQMCFEKYGKIWGIYDGRQPVMAILDPVLIKTILVKECYSTF
TNRRVFGLSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKLVKNI
EKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPSDPFVTNIRKFLKFSFLNP
LLIFIVLFPFMIPVLEKMNVTLLPTKVMDFFDAVFMKMKKEREEGYHVDRVDFLQLMI
DSQSSQDSSKSAREKDSYKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKRLQDEIDANLPNKAAPTYNVVMQMEYLDMVVNESLRLHPPGGRIERICKKTVEFNG
VTIPKDMVVMIPAYVLHRDPAYWPKPEEFRPERFSKENGENIDPYTFLPFGAGPRNCI
GMRFALLIVKVAMVVLLQNFSFKPCKDTPIPLVLDTKGFMQPKKPIILKMVPRAHSDP
QN

CYP3A80     Meleagris gallopavo (turkey) 
            DQ450082
            Shirley Yip, Roger Coulombe, Jr.
            Submitted to nomenclature committee Jan. 20, 2006
            Clone name CYP3A-F2
            90% to chicken 3A80 probable ortholog
MGFLPDLSPITWLLLVAFLSLLVLYGIWPYQTFKKLGIPGPQPV
PFLGTFLGYQQGILNFDQMCFEKYGKIWGIFDGRQPIMAILDPALIKTILVKECYSTF
TNRRVFGLSGRLESAVSMAVDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGEKLVKNI
EKKVANEELLDMKNIFGAYSMDVVASTSFSVDVDSMSKPSDPFVTNIRKFLKFSFLNP
LLMFIVLFPFMIPVLEKMNVTLLSNEVMDFFDVFFMKMKKEREKGYHMNRVDFLQLMI
DSQSSQDGSKTAEEKDSHKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKQLQDEIDANLPNKAAPTYNAVMQMEYLDMVVNESLRLYPAGGRIDRVCKKTVEFNG
VTIPKDMVVMIPIYVLHHDPEYWPKPEEFRPERFSKENRENIDPYTYLPFGAGPRNCI
GMRFALLVVKVAVVALLQNFSFRPCKDTPIPLVLDTKGFMQPKKPIVLKMIPRAHGDL
QN

CYP3A80     Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80049345-80104701
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            mdo1
            63% to CYP3A80 chicken (ortholog)
MTSYSGLSTETWTLLVAFVTLLILYGIWPYGIFKKLGIPGPRPLPFFGTFLEYRKGILEFDKQCFQKYGKMWGFYDGRLPIL
AILDPDIIKIVLVKEFYTLFTNRRNFGLNGILDSGITVAEGEKWKRIRSIISPTFTTGKLKEMFPIIKHHIDVLVNNIEKKV
AQDESVNMKDIFGAYSLDVITSTSFGVDIDSINKPNDPLLVHIKKLLSFSFMSPLLILILVFPSLVPILEKMNLSLLSKENI
DFLVNASRRIIADRKKSNSRDRVDFLQLMIDSQVMNGSRSEKRNNSPKALTEMEIVAQAVTFIFAGYETTSTTLNFITYNLA
THPEIQKKLLEEIDSTLPNKAVPTYDTIFQMEYLDMVVNETLRLFPLGGRIERICQKTAEINGITIPKGTVMLIPVYVLHHD
PEYWPEPEEFRPERFDQEGRKSIDPYVFLPFGAGPRNCVGMRFALLTLKTALVTLLQNFTMEPCKETPIPLELETKGFMQPK
KPIILKLVPRPRPDVED

CYP3A81     Xenopus tropicalis (Western clawed frog)
            See Xenopus pages for seq
            UCSC Browser scaffold_76:65898-87839 Aug. 2005 (xenTro2) assembly
            NM_001015786.1 59% to 3A5 from refseq database
            94% to CYP3A81a, 92% to CYP3A82v1, 91% to 3A82, 88% to CYP3A81b
MNLIPHLSTGTWILLAALLVLILLYGIWPYGYFKKMGIPGPTPL
PFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNF
TNRRNFGLNGPFESAITIAEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNI
QGYVEKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLKTGLLSP
LLILVVIFPFLRPILEGLNLNFVPKDFTEFFMNAVTSFREKRKKGDHSGRVDLLQLMM
DSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYETTSTALSYLFYNLATHPDVQQRL
HEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSKQNVEINGVSIP
KGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFLPFGDGPRNCIGLRF
ALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVLKFLSRAAAHE

CYP3A81a    Xenopus laevis
            AAI29607.1 GenPept
            94% to CYP3A81 (possible ortholog), 
            90% to CYP3A81b, 90% to CYP3A82v1, 89% to 3A82
            formerly CYP3A125
            renamed CYP3A81a, presumed ohnolog to CYP3A81b (90%)
            CYP3A81a and CYP3A81b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE

CYP3A81b    Xenopus laevis
            AAH60496.1 GenPept  
            90% to CYP3A82v1, 90% to CYP3A81a, 89% to 3A82, 88% to CYP3A81
            formerly CYP3A123
            renamed CYP3A81b, presumed ohnolog to CYP3A81a (90%)
            CYP3A81a and CYP3A81b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE

CYP3A82v1   Xenopus tropicalis (Western clawed frog)
            UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
            98% to 3A82 (different scaffold, but possible allele)
            92% to 3A81, 90% to CYP3A81b, 90% to CYP3A81a
            renamed CYP3A82v1, adjacent to CYP3A81
            formerly CYP3A122
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE

CYP3A82v2   Xenopus tropicalis (Western clawed frog)
            UCSC Browser scaffold_1918:6381-20049 Aug. 2005 (xenTro2) assembly
            BX779027 CX415432.1 93% to 3A81 N. Abdletawab
            CX415433 = mate pair
            Trace archive 243619963 419527443 418746304
            476067541 (exon 1)
            416306382 joint before I-helix
            98% to 3A82v1 (different scaffold, possible allele), 
            91% to 3A81, 
            89% to CYP3A81b, 89% to CYP3A81a
MNLIPHLSTGTWILLAVLLVLILL (2)
YGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDIECFKKYGR
MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPLESAITVAEDEQWKRIR
SVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDVIGAYSMDVITSTSFS
VNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQFFM
NAVTSFREKRKKGDHS (0)
GRVDLLQLMVDSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGYETTSTALSYLF
YNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSK
QNVEINGVIIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTFLPFGDG
PRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVLKFLSRAAAHE*

CYP3A83     Xenopus tropicalis (Western clawed frog)
            CX982440.1 DT453227 
            UCSC Browser scaffold_320:299565-317579 Aug. 2005 (xenTro2) assembly
            60% to 3A80 chicken, 56% to 3A81 57% to 3A82
            96% to 3A120, 91% to 3A121, 89% to CYP3A83a
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYKLFKRYGIPGPTPIPFIGTFL
GNRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLS
GPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNKEPLD
MKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVP
LLDKMNFCFLSLKILNFFKDAVASIKKKRQKGTH
EDRVDFLQLMVDAQSNEGKSVPEEEKHGYKE
LSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDA
LMKMEYMDMVINESLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHLNPEIWP
EPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCK
DTPVPLKICTKGYLKPTKPIILNLIPKVGQTVEE*

CYP3A83a    Xenopus laevis
            AAH84827.1 GenPept
            89% to 3A83, 89% to 3A120, 88% to 3A121
            formerly CYP3A124
            renamed CYP3A83a, presumed ohnolog to CYP3A83b (91%)
            CYP3A83a and CYP3A83b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A83, CYP3A120 and CYP3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE

CYP3A83b    Xenopus laevis
            EST EG565461.1
            91% to CYP3A83a
            CYP3A83a and CYP3A83b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A83, CYP3A120 and CYP3A121
GIMKFDMECFKKYGKVWGFYDGPQPVLAIVDPVIIKSIMVKECYNNFTNRRDFGLSGPLK
SSVFLSKDDHWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIQKKIDNNEPLDMKDI
FGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLLT

CYP3A84P   dog pseudogene between SDK1 and FOXK1 
           UCSC browser chr 6 
           The human pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
           are in a syntenic location with this pseudogene
16005702-16005782 (+) strand aa 47-73 exon 1
ISNTCCFLQGFCDFDEKCFRKYARTWG
16125771-16125865 (-) strand aa 74-105 exon 2
IIYRGRQPVLVILGSLLFMRVLVKEFYILFTNR
16124466-16124555 (-) strand 112-141 exon 5
XXXXXXGSLESSLIFAKGDKWNWLRTVISWTFASGK 
16119415-16119480 (-) strand 177-198 exon 7
GAFSRDVIISISFGVEADPISN
16044198-16044386 (+) strand 219-277
LFLSTIVFTFPALLLKLLNVIQLPKEGQEFFIGSISKMERKASERNLHSKQGLLVEKRQMFLN 
16113643-16113882 (-) strand aa 332-419 exon 11
IQEPLHKCLSLQQAAPTCEVLLQVEYLVTV*MTPSGSTSRGMSGRVWKKT
PEGMLVMITIYRLLRHPMHWLEPEESCPER

Cyp3a85-ps    rat
           GenEMBL NW_001084671.1 4655562-4666355 (-) strand
           86% to 3A2 new gene 
           (numbering is relative, taken from a larger sequence)
           missing first four exons on two different contigs
67133  DLGPLGIMSKAITFSKVEEWKRYRAFLSPTFTSGKLKE  67020
66942  MFPIVEQHGDILVKYLRREDEKGKPAPVKQ  66853
       VFGAYSMDEITSTSFGVSVD  66373
66372  FLTNPKDTFVEKTKKLLRFDFFDPLFLSVG
63877  LFPFLTPIYEMLNICMFPKDSIAFLQKFVYRMKETRLDSKHK
62887  HRVDFLQLMLNAHNNSKDEVSHK  62819
60567  ALSDVEIIAQSVTFIFAGYEITSSTLSFVLYSLATYPDIQKKLQEEIDGALPNK  60406
58571  APPTYDIVMEMEYLDMVLNETLRLYPVGNRLERVCKKDIELGGVFIPKGSVV  58416
58415  MIPTYPLQRDPQHWTEPEEFHPER  58344
56749  FSKENKGSIDPYVFLPFGHGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQ  56588
53720  IPLKLSIQAILEPEKAIVLKVVPWDAVITGA  53628

CYP3A86    catfish
           No accession number
           David S. Barber, Margaret O. James
           76% to CYP3A65, 93% to CYP3A87
           intestine

CYP3A87    catfish
           No accession number
           David S. Barber, Margaret O. James
           76% to CYP3A65, 93% to CYP3A86
           liver

CYP3A88X   Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          86% TO 3A22 AND 3A39v1, 76% to human 3A4 and 3A5
          partial seq.
          name changed to CYP3A46 after whole sequence known

CYP3A88X   Sus scrofa (miniature pig) 
          3 aa diffs to CB479861.1 EST, probably the same seq.
          F22946.1 extends seq toward N-term.
          AJ959509.1 overlaps F22946 with 1 aa diff in 42
          Be aware this may be a hybrid of two or more gene sequences.
          BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
          DB799225.1
          92% to 3A39v1
          name changed to CYP3A46 
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*

CYP3A89   horse
          EU014892
          Heather Knych
          Submitted to nomenclature committee June 22, 2007
          79% to 3A74 cow, 80% to CYP3A4 and CYP3A5 human
          80% to CYP3A39v1 pig

CYP3A89   horse
          UCSC Browser chrUn:228948991-228982779, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca2 
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYHKGIWDFDKKCFEKYGKMWGTYHGTKPVL
AITDPDMIKTVLVKECYSVFTNRRPFGPFGFMKSAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPILGQYGDVLVRNLKKEA
EKGKPITLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLFSFDFLDPLLLSITLFPFLNAVFEVLNVFVFPKSVT
DFFIKSVKRMKESRLKDKEKHRVDFLQLMINSQNSKELDTHKALSDLELVAQSIIFIFAGYETTSSSLSFLMYFLATHPDVQ
QKLQEEIDVTFPNKAPPTYDALVQMEYLDMVLNESLRLFPIAVRLERVCKKDVEINGVFIPKGTVVMVPTFALHKHPEFWPE
PEEFRPERFSKENKDSINPYIYLPFGAGPRNCIGMRFALMNMKLALVRMLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVSGA

CYP3A90     Callithrix jacchus (marmoset)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Cja3a5a
            87% to 3A5 human, paralog of CYP3A5

CYP3A91     Otolemur garnettii (galago)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oga1
            82% to 3A92, 79% to 3A98 dog, 79% to 3A4 human, 78% to 3A5 human

CYP3A92     Otolemur garnettii (galago)
            No accession number
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oga2
            82% to 3A5 human, 83% to 3A4 human, 
            82% to 3A91, 80% to 3A98 dog

CYP3A93   horse
          UCSC Browser chrUn:228891415-228923288, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca1 
MDLIPSFSTETWVLLATSLVLIYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYRKGIWNFDRKCFKKYGKMWGVYDGRRPVL
AVTDPDMIKTVLVKECYSVFTNRRPFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLMVLFPFLQPIFEVLNISLFPKSAI
DFFTKSVKRMKESRLKDKDKHRVDFLQLMINSQNSKELDTHKGLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQ
QKLQEEIDAIFPNKAPPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFSLHRASEFWPE
PEEFRPERFSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVNGA

CYP3A93   horse 
          AAWR02042202.1 (+) strand
          WGS section of NCBI
          79% to CYP3A5
23223 MDLIPSFSTETWVLLATSLVLIYL (2) 23294
27388 YGTYTHGLFKKLGIPGPTPLPFFGNVLSYRK (0) 27480
29587 GIWNFDRKCFKKYGKMWG (2) 29640
30212 VYDGRRPVLAITDPDMIKTVLVKECYSVFTNRR (0) 30310
35597 PFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKE (0) 35710
35974 MFPIIGQYGDVLVRNLRKEAEKGKPVTLKD (1) 36063
37396 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLM 37542
40831 IVLFPFLQPIFEVLNISLFPKSAIDFFAKSVKRMKESRLKDKDK 40962
42047 HRVDFLQLMINSQNSKELDTHK 42112
45520 GLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQQKLQEEIDAIFPNK 45681
46292 APPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFS 46465
46466 LHRASEFWPEPEEFRPER 46519
52681 FSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQ 52842
54999 IPLKLGNQGLLQPQKPIVLKVESRDGTVNGA* 55094

CYP3A94   horse
          UCSC Browser chrUn:229025212-229061564, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca3 
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYLKGFWDFDKKCFKKYGSMWGIYDGPQPVL
AITDPDMIKTVLVKECYSVFTNRRSLGPVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKET
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSITLFPFLKAVFEVIHIYMFPKRVT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQDEIDVTFPNKALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFILHRASEFWPE
PEEFCPERFSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKIGNQGLIQPQKPIVLK
VESRDGTWNGA

CYP3A94   horse 
          AAWR02042203.1 78309-114672 (+) strand
          WGS section of NCBI
78309 MDLIPSFSMETWVLLATSLVLLYL (2)
82015 YGTYTHGLFKKLGIPGPTPLPFLGTVLGYLK (0) 82107
84003 GFWDFDKKCFKKYGSMWG (2) 84056
84650 IYDGPQPVLAITDPDMIKTVLVKECYSVFTNRR (0) 84745
88583 PVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKE (0) 88687
88948 MFPIIGQYGDVLVRNLRKETEKGKPVTLKN (2) 89037
90379 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSI (1) 90525
95603 TLFPFLKAVFEVIHIYMFPKRVTDFFTKSVKRMKESRLKDKQK (0) 95731
96393 HRVDFLQLMINSQNSKEMDTHK (1) 96458
99613 ALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQQKLQDEIDVTFPNK (0) 99774
109466 ALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFI 109639
109640 LHRASEFWPEPEEFCPER 109683 (2)
112163 FSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0) 112324
114577 IPLKIGNQGLIQPQKPIVLKVESRDGTWNGA* 114672 

CYP3A95   horse
          UCSC Browser chrUn:229104699-229137172, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca4
MDLIPSLSMETWVLLATSLVLLYLYGTYSHGHFKKLGIPGPTPLPFFGTVLGYIKGVLAFDKKCFKKYGKMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKPITMKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSILFFPFLIPVYEALNIFVFPKCVT
DFFIKSVKKMKESRLKDKAKQRVDFLQLMINSQNSKEIDNLKVLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQ
QKLQEEIDATFPNKAPPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVLHQHPEFWSE
PEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQIPLKLVSQGLIRPEKPIVLK
VESRDGTMSGA

CYP3A95   horse
          AAWR02042203.1 157804-190276 (+) strand
          WGS section of NCBI
157804 MDLIPSLSMETWVLLATSLVLLYL 157875 (2)
161963 YGTYSHGHFKKLGIPGPTPLPFFGTVLGYIK 162055 (0)
163958 GVLAFDKKCFKKYGKMWG 164011 (2)
168704 FYDGRQPVLAITDPDMIKTVLVKECYSVFTNRR 168802 (0)
172355 SFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKE 172468 (0)
172730 MFPIIGQYGDMLVRNLRKEAEKGKPITMKE 172819 (2)
174148 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSI 174294 (1)
178624 LFFPFLIPVYEALNIFVFPKCVTDFFIKSVKKMKESRLKDKAK 178752 (0)
179820 QRVDFLQLMINSQNSKEIDNLK 179885 (1)
183504 VLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQQKLQEEIDATFPNK 183665 (0)
186095 APPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVL 186271
186272 HQHPEFWSEPEEFRPER 186322 (2)
187860 FSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQ 188021 (0)
190184 IPLKLVSQGLIRPEKPIVLKVESRDGTMSGA* 190279 

CYP3A96   horse
          UCSC Browser chrUn:229197172-229225636, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca5
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGFDTECLKKYRKMWGFYDGRQPVL
AITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEA
EKGKPIALKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFLFPKSVT
DFFTKSVKRIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQ
QKLQEEIDATFPNMAPPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFALHRDTELWPQ
PEEFHPERFSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQIPLKLVTYGFLQPEKPIVLK
VESRAGTVSGA

CYP3A96   horse 
          FJ755695
          Heather Knych
          Submitted to nomenclature committee Jan. 30, 2009
          Equine CYP450 Proposed Sequence 47
          72% to CYP3A4, lower case region out of frame
          77% to CYP3A4, 84% TO CYP3A89 if frame restored
          note: this seq has 12 diffs to the genomic sequence
          5 diffs are in the frameshifted region 
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGF
DTECLKKYRKMWGFYDGRQPVLAITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISI
SEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEAEKGKPIALKDIFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFL
FPKSVTDFFTKSVKGIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSI
IFIFAGYEpsavlfflfcifwpltlmssrscrrrlmqlppiwhlPTYDALVQMEYLDMVL
NESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFVLHRDTELWPQPEEFHPERFS
KENKDSINLYIYMPFGNGPRNCIGMRFVLMNMKVAVVRVLQNFSFNPCKETQIPLKLVTY
GFFHPEKPIVLKVESRAGTVSGA* 

More P450-like translation of the lower case region
XSSSLLSFLYLLATHPDVQQKLQEEIDATSPNMAP

CYP3A96   horse
          AAWR02042203.1 250268-278726 (+) strand
          WGS section of NCBI
250268 MDLIPSFSVETWVLLATSLALLYL (2) 250339
253991 YGIYTHGLFKKLGIPGPKPLPFLGTLLGYRK (0) 254083
256253 GFGGFDTECLKKYRKMWG (2) 256306
256882 FYDGRQPVLAITDPDLIKTVLVKECYSVFTNRR (0) 256980
260533 SFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKE (0)
260908 MFPIIGQYGDVLVRNLKKEAEKGKPIALKD (2) 260997
262303 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSI (1) 262449
267216 TIFPFLNPVFELLNIFLFPKSVTDFFTKSVKRIKESRLKDKEK (0) 267344
268416 QRVDFLQLMINSQNSKEMDTHK (1) 268481
271703 ALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQQKLQEEIDATFPNM (0) 271864
274219 APPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFA 274392
274393 LHRDTELWPQPEEFHPER (2) 274446
275949 FSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQ (0) 276114
278634 IPLKLVTYGFLQPEKPIVLKVESRAGTVSGA* 278729 

CYP3A97   horse
          UCSC Browser chrUn:229268263-229304613, Jan. 2007 (equCab1) assembly
          Huan Qiu
          Submitted to nomenclature committee May 30, 2007
          eca6
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDFDKKCFKKYGKTWGFYEGRLPVL
AITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAIIRSEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEA
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISVFPKSVT
DFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIVFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQKEIDVTFPNKVPPTYDALLQMDYLDMVLNESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPE
PEEFRPERFSKENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTEAIVKPQKPIVLK
VEPRDGTMTGA

CYP3A97   horse 
          FJ755696
          Heather Knych
          Submitted to nomenclature committee Feb. 16, 2009
          Equine CYP450 Proposed Sequence 43
          85% TO CYP3A89, 76% to seq 47, 75% to CYP3A5
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDF
DKKCFKKYGKTWGFYEGRLPVLAITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAITR
SEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEAEKGKPVTLKNIFGAYS
MDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISV
FPKSVTDFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSI
VFIFAGYETTSTSLSFLMYLLATHPDVQQKLQKEIDVTFPNKVPPTYDALLQMDYLDMVL
NESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPEPEEFRPERFS
KENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTE
AIVKPQKPIVLKVEPRDGTVTGA*

CYP3A98   Canis familiaris (dog)
          XP_536868.2 GenPept
          95% to CYP3A12, 91% to 3A26 
MDLIPSFSMETWLLLATSLVLLYLYGTYTHGVFKKLGIPGPTPLPFVGTALGYRKGFSVFDENCFRKYGRMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKSINLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENIKKLLKFDFLDPFFFSILLFPFLTPVFEVLNIWLFPKSVT
DFFTKSVKRMKENRLKDKQKHRVDFLQLMINSQNSKETDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQ
QKLQEEIDATFPNKALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE
PEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLK
VEPRDGSVNGA

CYP3A99   Canis familiaris (dog)
          XP_546969.2 GenPept
          95% to seq a + f from dog page, (exons 10, 11 do not match) 
          87% to 3A12, 85% to 3A26
MDLIPSFSTETWLLLATSLVLFYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYRNGFCDFDEKCFRKYGRMWGFYDGRQPVL
AIMDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKAISLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSIILFPFLTPLYEMLNIWLFPKKIT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMNTHKALSDLELVAQSIIFVVAGYETTSTSLCLLMYELATHPDVQ
QKLQKEIDATFPNKAAPTYDTLVQMEYLDMVLNESLRLYPITGRLVRVCKKDVEISGVFIPKGTVVMVPTFTLHQDPDIWPE
PEKFQPERFSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQIPLKLSSQGLIRPEEPIILN
VEPRDGSVRGA

CYP3A100   Bos taurus (cattle)
           XP_584699.3 GenPept 
           95% to 3A74, 91% to 3A76, 80% to 3A28 
MELIPSFSMETWVLLSISLVLLYLYGTYSHGLFKKLGVPGPRPLPYFGNVLSYRKGVCEFDEECFKKYGKMWGIFEGKHPLL
VITDPDVIKTVLVKECYSVFTNRKVFGPRGIMKNAVSVAEDEQWKRIRTLLSPAFTSGKLKEMFPIIGKYGDVLVRNLRKEA
EKGKSVNMKEVFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSVVLFPFLVPILDVLNITIFPKSAV
NFFTKSVKRIKESRLKDNQKPRVDFLQLMINSQNSKETDNHKALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQ
QKLQEEIDATFPNKAPPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE
PEEFRPERFSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLK
VVLRDGTISGA

CYP3A101    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80414036-80431004
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo2
            89% to CYP3A102, 89% to 3A104, 89% to 3A103, 88% to 3A105, 69% to 3A89
IFTLPYRYGTRTHKLFKNLGIPGPTPLPFIGTVLSYHKGIEGFDYGCFKKYGKTWGFFDGTKPVLAIMDPETIKTVMVKECY
SVFTNRRMLGLSGILEKAISIAEDEQWKRMRTVLSPAFTGGKLKEMFPIIKQYGDVLVKNMKKEAEKSKPVTLKDILGAYSM
DVITSTSFGIHVDSLNNPNDPFVRKIRKLIRFSFRDPLILSIVIFPFLIPLFKKLDITIFSKDVTDFLAKSILKIKEERKKT
EKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYESTSSVLCFLFYQLATNPGIQEKLQKEIDAFLPNKEA
VTYDALVQMEYLDMVINENLRLYPITGRIERIAKKPVELNGLMIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKES
INPYVYLPFGVGPRNCLGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSYRPLLAPSVPIVLQAVLRNKKGNQH

CYP3A102    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80549861-80580975
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo3
            90% to 3A104, 89% to 3A103, 89% to 3A105, 89% to 3A101, 80% to 3A106
MNIIPNLSAGTWTLIILFLTILYLYGTRTHKLFKNIGIPGPTPFPFIGTILYYRKGIVGFDYGCYKKYGKTWGFFDGTKPVL
AIMDPETIKTVLVKECYSVFTNRRMLGLSGILEKAISIAEDEEWKRIRTVLSPAFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDIIISTSFGIHVDSLNNPNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFSKDAT
DFLGKSILRIKEERKKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIVFIFAGYESTSSVLSFLFYHLATNLE
IQEKLQKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLYPISGRIERIAKKTVQLNGLTIPQGTVVMTPPYVLHRDPEYW
PEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIAMRFALMGMKVAVSRLLQEFSFIPCKETPIPLKLNNQPLLTPSVPIV
LQAVLRNKKGNQH

CYP3A103    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80611887-80640626
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo4
            99% to 3A105, 99% to 3A104, 89% to 3A102, 84% tpo 3A106
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH

CYP3A104    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80672879-80701151
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo5
            99% to 3A103, 98% to 3A105, 90% to 3A102, 89% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGILEKAISIAEDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERKKSTGKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH

CYP3A105    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80734341-80768989
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo6
            99% to 3A103, 98% to 3A104, 89% to 3A102, 88% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIKKLIRFSFLDPLILSTTIFPFLIPLFNKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH

CYP3A106    Monodelphis domestica (opussum)
            UCSC Browser Opossum, chr6:80783381-80814644
            Jan 2006 (monDom4) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Mdo7 note: this seq has an assembly defect in the middle
            85% to 3A105, 84% to 3A103
MNIIPSLSAGTWTLIVVFLTLLYLYGTRTHKLFKNLGIPGPKPLPFFGTVFSYRKGLVNFDYDCFKKYGKTWGFYDGRQPVL
ATMDPETIKTVMVKECYSVFTNRRSFGPVGSLESAITVAKDDQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKNKPVTMKDILGAYSMDVITSTSFGIHVDSLNNPNDPFVREIKKLIRFNFLDPLILSVAIFPFLTPLFNKLDITVFPKDAI
NFLAKSLISMFSTIFSALVFILHYFFQHRVDLLQLMMDSQSSKNSEPHSHKDLSDQEILAQSIIFLFAGYETTSSVLSFLFY
HLATNPEIQEKLHKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLFPIAGRVERVAKKTVELNGLTIPKGTVVMTPPYVL
HREPEYWPEPEKFHPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMNMKVAVSRLLQEFSFRTCKETQVPLKLGNQPIL
TPTIPIVLQAELRNKKTN

CYP3A107    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25769723-25784944, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan1
            78% to CYP3A108, 75% to CYP3A109, 71% to CYP3A110, 57% to CYP3A113
MSSILNFSIETWILLGTFLALMILYGIWPFRVFTKSGIPGPRPVPFFGNILEYSQGIIEFDKKCFQKYGKIWRLFEGRQAMV
AVLDLEIIKTVLVKEVFSSFTNRRRIGIEGIMEESIIGAEDEQWKELRILISPTFSSGKLKEMLRIMIHYGEILVKTIWKKA
EKNQNVIVKDYYGAYSLDVITSTSFGVDVNSLNKMNDTYFKEVKKLSSVDFFSPLLALTSIFPFITPLLNLLDISLFPSDSV
EYIKRFVHKIRESRHQDNQQHRADLLKLLLDSQNPKEGLKGKKGLSDTGILAQAVAFVFAGYETTSSALSFISYNLATHPDV
QQKLQEEIDKVLPNKSPLTYDAIVQMEYLDMVINETLRLYPIGPRLERMCKKTLEINGLTIHKGTCVVIPIAVLQHDPNYWT
EPDEFRPERFSKEMREKRDPYTFIPFGVGPRNCIGMRFALLNMKVAIIGLLQNFSLRTCQETQIPLELNSMGFLTPKKPIVL
QFIPRADTKSQD

CYP3A108    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25741772-25760791, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan2
            79% to 3A109, 78% to 3A107, 75% to CYP3A110, 56% to 3A37 chicken
MSSIFSFSIETWILLGTFLTLMILYGIWPYGVFTKRNIPGPWPVPFLGNIQEYSQGLMVFDKKCSEKYGKIWGLYEGRQAII
AVLDLDIIKKVLVKEVFSSFTNRRNTGIEGILELAVSSAEDEHWKELRTLMSRTFTSGKLKEMLPIMTHYGEVLVRNIWRKA
EKNENVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDTFVKEIKKISSIDFFSPLFALISTFPFMIPLLKLLNINLFPNDSV
EYFKRFLHKVKERRHQDNQQHRVDFLQLMLDSQNPKEGSKGKGGLSDAELLAQAFAFIFAGYETSSNTLSFISYNLATHPDV
QEKLQAEIDTVLPNKSPLTYDALVRMEYLDMVINESLRLYPISSRLERMCKKTTEINGLTIPKGTCVVIPLFILQKDPNYWL
EPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLSIKVAMIGLLKNFSLRTCQETQIPPEINSFGLLTAKKPIVL
RYIPRADTKIKD

CYP3A109    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25693551-25724066, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan3
            79% to 3A108, 75% to 3A107, 77% to 3A110, 55% to CYP3A37 chicken
MSSILSFSIETWILLGTFLALMILYGIWPYGVFTKLRIPGPRPIPFLGNILDYSQGMDEFDKKCFQKYGKIWGLYEGRKAKI
AVLDLDIIKSVLVKEVFTNFTNRQMAGIEGIMSESIFSAKDERWKELRTLVSPTFTSGKLKEMVPMMIQYGEVLVKNLQNKV
EKNQNVTIKDYFGAYNLDVITSTSFGVDIDNLNKMNNTFVKEIKKLTSINFFSPLFALISVLPFMIPLLKLLNINTFPNDSV
EYFKRFMDKIKERTQQGNPQQRMNFLQLMLDTQNPKEGLKNKGGLSDAEILAQAFSFIFAGYETSSTTLSFISYNLATHLDV
QKKLQEEIDEVLPNKAPLTYDALVQMEYLDMIINETLRLYTVGSRLERICKKTMKINGLTIPKGMTVVIPVSCLHSDPNYWV
NPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLNIKVAIIGLLQNFSLRTCQETQIPLEVNSFGLLTTKKPIVL
RFIPRAEIKSKD

CYP3A110    Ornithorhynchus anatinus (platupus)
            UCSC Browser, chr2:25660643-25688288, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan4
            77% to CYP3A109, 75% to 3A108, 71% to 3A107, 56% to 3A37 chicken
MRGILNFSIETWILLGSFLTLVILYGIWPFGVFTKLGIPGPRPIPFFGNILEYAQGTMHFDKKCFQKYGKIWGFYEGWKAKI
AVLDLDIIKRVLVKEVFTNFTNRQNSGIEGILKHSVFAAKDKHWKKLRTLISSTFTSGKLKEMVPTIIHYGEILVKNIWYKA
EKNQNVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDRFVKEIRKLSSVDFFPPIFVLISVLPFITPLLKLLNINIFPNDSV
EYFKRFMDNIKGTHHQGNQQQQVNFLQMMLDTQNPKEGSKAKGVLSDAEILTQAFAFIFAGYESSSSVLSFIAYNLAIHPDV
QQKLQEEIDTVLPNKLPLTYEALVQMEYLDMVINETLRLYSVGPRLQRVSKKTTVINGLTIPKGMTVMIPLTCLHREPKYWL
EPDEFHPEIPLELTARGFLIPQKPIVLQFIPRAEIKKG

CYP3A111    Ornithorhynchus anatinus (platupus)
            UCSC Browser, Contig7638:3143-20297, Mar. 2007 (ornAna1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            oan5
            66% to CYP3A80 opossum (possible ortholog), 
            63% to 3A113, 60% to 3A80 chicken
GGLDSSLTIAEYHTWKRIRTIVSPAFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIFGSYSLDVVTSTSFGVDI
DSMNNPNDPFVKQINKLLSFTFLSPLILLTVVCPFLVPVFEKMNLSLFPREFLEFFVGVTRNFKEKRQKGVHTGRVDFLQLM
VDSQSSDSNSEPKMTDTEISTQAIIFIFAGFETTSSTLNFVSYNLATHPEVQKKLQEEIDSILPNKASPTYESISQMDYLDM
VVQETLRLFPPGGRIERVCKETIQIKGLTIPKGTVVIIPAFVLHRDPEHWPEPEKFLPERFSKEEKASHNPYVFLPFGAGPR
NCIGMRFALLNMKAALIHLLQNFSVEPCKETPMPLELDSTGFMKPKKPIILKLVPRSGVDSED

CYP3A112    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:62196-70979, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca1
            84% to CYP3A113, 69% to CYP3A114, 66% to 3A80 chicken
            62% to CYP3A80 Monodelphis domestica, 60% to 3A37 chick
MDFFSFFSIQTWSLLGIFLLLLMLYGIWPYNFFKKLGIPGPRPLPFIGTFLEYNKGVLDFDERCRQKYGKIWGFFDGRQPVM
AIMDPVIIKTILVKECYTHFTNRRDFGLNGDFDASVLVAQDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGEMLVKNVQKKG
ENGEYIDTKDIFGAYSMDVITSTSFSIDIDSINNPKDPFVVSMKKIIKTNFVNPLLLLIVIFPFLRPVLEALNISLAPTSAT
GFLRGALRKIKSDRQKNVHQDRVDFLQLMVDSQISGDVFDGTNSYKALNDREILAQAFTFVFGGYETTSSTLGYMAYCLATH
PDVQKKLQDEIDEVLPDQATPVYDALLQMEYLDMVINETLRLYPPGGRIERVCKNTVEINGVTIPKGTVAMIPAFVLHRDPE
FWPEPEEFRPERFSKENKEFLNPYVFLPFGIGPRNCIGMRFALLSLKVATVVLMQRFSFRTCKETPIPLELESKGFMRPKNP
IRLKFVPRVMAESNE

CYP3A113    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:49268-57033, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca2 Browser is missing first exon in a seq gap
            84% to CYP3A112, 68% to 3A80 chicken, 72% to 3A114
            61% to 3A37 chick
GIWPYNFFKKLGIPGPRPLPFIGTFLEYRKGVLDFDEMCHKKYGKIWGFFDGREPVMAILDPVIIKTILVKECYTHFTNRRD
FGLNGDFDSSILTVQDEQWKRIRTVLSPNFTSGRLKEMFPIINHYGEMLVKNIQKKVENGEYIDTKDIFGAYSMDVITSTSF
SIDIDSINNPNDPFVTNIKKIVKFNFVNPLLVLIVIFPFLTPVLEALNFSLTPTSVTNFIKESIKKLKKDRQKNLHKDRVDF
LQLMVDSQISGEILDDSKSYKALNDKEILTQAIIFVFAGYETTSSTLSYMAYCLATHPDVQQKLQEEIDEALPNQATPVYEV
LLQMEYLDMVINETLRLYPPGGRIERVCKTTVEINGVTIPKGTVTMIPAFVLHRDPEFWPEPEEFRPERFSKENKETLDPYT
FLPFGAGPRNCIGMRFALLSLKVAMIVLLQRFSFRTCEETPIPLELQSQGFMTPKKPIRLKFVPRVMAESKE

CYP3A114    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:33297-45513, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca3
            72% to CYP3A113, 69% to 3A112, 61% to 3A80 chicken
            58% to 3A37 chick
YGIWPYNFFKKLGIPGPRPLPFIGTLHKHRIGVNNFDQKSHEKYGKIWGLFDGRQPVIAILDPAIIKIILVKHFYTHFTNRR
DFGLNGELDTSIAITRDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGKILVESAQKKVENGEAIDLKSFFGGYSMDVTTSTS
FSINVDSINNPNDPFVMHIKTFLKFDTFDPVILLVVIFPFLRPLFERLNFNMVAPSSFTTFFIDVLKKVKKDRQKNDHKNRV
DFLQLMVDSQISGNIPEEAKMYKALTDKEILTQAIVFIFAGFETTSTTLSFLSHCLATNPDVQQKLQEEIDATLPDQATPTY
NAIQQMEYLDMVVNETLRLYPVGGRIERDCKNTVEINGVTIPKGTVIVIPTFPLHRDPEYWPEPEEFRPERFSKENKETQNP
YVYLPFGAGPRNCIGMRFALLVVKVAIVVLLQKHTLRPCKETQIPLEVHGQVLLEPKKTIKLKLVRRAGLEE

CYP3A115    Anolis carolinensis (green anole lizard)
            UCSC Browser scaffold_533:424-21366, 
            Lizard Feb. 2007 (anoCar1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            aca5 partial seq
            54% to 3A37 chicken 
YGIWPYGVFKKLGVPGPTPLPFIGTALAYRNGILQFDKACFKKYGKVWGFYDGRTPVLAVTDPAVIKAVLVKECYTVFTNRR
KFGPTGKLEKAVSLAEDDTWKRIRTVLSPTFTSGKLKEMLPIIQHYAEILIKNFSEKADKGETVDIKDVLGPYSMDVVASSS
FGVNINSMNNPQDPFVKQAKKLVKFNFFSPLFVLMYMVPWLTPVLNKMNITLFSAEAVDFFAKAIGKIKEQRKQEMDKGRVD
FLALMIESQKAEAKTQINGMNQTYKFSKENKGRIDPYVYLPFGAGPRNCIGMRFAFLILKAGAVSLLQNFTFKPCKETQIPM
ELSTTGLMIPKKPIILKAIPRASSSH

CYP3A116    Dicentrarchus labrax (European sea bass)
            ABB90404.1 GenPept
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Dla3aX
            Possible Ortholog of CYP3A68
            87% to 3A68 bass
MGYFFYFSAETWTLLVTLITLFFVYVYWPYGTFKKMGIPGPKPIPFFGTMLAYRKGFMNFDSECFQKYGKTWGIYDGRQPVL
CITDVSMIKTVLIKECYSLFTNRRNFRLNGPLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFGIMKQHSANLISSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDLDSLNNPSDPFVTNIKKMLKFDLFSPLFLIVAFFPFMGPVFEKMEFSFFPTYVT
DFFYAALQKIKSNRETSKQKSRVDFLQLMIDSQKNNDLSGVEQDKGLNDHEILSQAMIFIFAGYETSSSSLTFLAYNLATNP
AVMKRLQQEIDSTFPNKAPIEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVELNGIVIPKDMVVMIPTWPLHRDPDL
WPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRFALVMMKLAIVEVLQRYSFSVCKETEVPFEMDIQGLLMPKRPI
KLKLEPRSEPSS

CYP3A117    Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4870920-4874088, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33062
            Paralog of CYP3A68
            93% to 3A119, 93% to 3A118, 81% to 3A68 bass, 
            81% to 3A68 Dicentrarchus
MGFSLFLSAETWTLLVALVTLLFMYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFEGRQPVL
CITDPAMIKTILIKECYSLFTNRRNTRLNGQLHDALTVAENHQWRRIRSVLSPSFTSGKLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKLLNIDFFSPVFLIVAFFPFLGPIMEKMEFSLFPKSVT
DFFYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIVPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSL
WPEPEAFKPERFSKENKDSIDHYTYMPFGAGPRNCIGMRFALMMMKLAMVEILQRFSLSVCKETEIPLEMDTQAVVMPKRPI
KLKLVSR

CYP3A118    Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4859354-4863677, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33063
            Paralog of CYP3A68
            95% to 3A119, 93% to 3A117, 83% to 3A68 bass
MGFSLFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGIPGPQPIPFFGTMLAYRKGITTFDEDCSKKYGKVWGIFDGRQPVL
CITDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDILSPLFLIVAFFPFLGPIMEKMEFSFFPKSVT
DFFYSALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIILRLERVAKATVEINGIVIPKDMVVAVPTWPLHRDPSL
WPDPEAFKPERFSKENKESIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVENLQRFSFSVCKETEIPLEMDVQDLLMPKRPI
KLKLVSR

CYP3A119    Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4853058-4857963, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33064
            Paralog of CYP3A68
            95% to 3A118, 93% to 3A117, 87% to 3A68 bass, 
            86% to 3A68 Dicentrarchus
MGFFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFDGRQPVLCI
TDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKADK
DEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDFFSPVFLIVAFFPFMAPILEKMEFSFFPKSVTDF
FYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSSLSFLAYNLARNPHI
MKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSLWP
EPEAFKPERFSKENKDSIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVEILQRFSFSVCKETEIPLEMDVQGLLMPKRPIKL
KLVPR

CYP3A120    Xenopus tropicalis (Western clawed frog)
            UCSC Browser scaffold_320:325056-341660, Aug. 2005 (xenTro2) assembly
            Huan Qiu
            Submitted to nomenclature committee May 30, 2007
            Xt3202
            96% identical to CYP3A83, adjacent on chr, 90% to 3A121
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRKGLMEFDMECFKKYGKVWGIYEGQKPLL
AIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVLVSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEKHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNI
ATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKP
TKPIILNLIPKAGQTVEE

CYP3A121    Xenopus tropicalis (Western clawed frog)
            UCSC Browser scaffold_320:348830-370189 Aug. 2005 (xenTro2) assembly
            Huan Qiu
            Submitted to nomenclature committee May 30, 2007
            Xt3203 adjacent to CYP3A120, 91% to 3A83, 90% to 3A120, 
            88% to CYP3A83a
MTFLPDFSKETWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRHGLMEFDMKCFKKYGNVWGFYDGPQPVL
AILDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVLMSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLITILCPFLVPLLDKMNFCFLSSKFL
KFFKDAVASIKKKRQKGAHMDRVDFLQLMVDAQSNEGESVPEEEKHRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNI
ARYPDVQRKLEEEINTLLPNKAPPTYDALMKMEYMDMVINETLRLLPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKP
TKPIILNLVPKGAQTTEEQI

CYP3A122X   Xenopus tropicalis (Western clawed frog)
            UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
            98% to 3A82 (different scaffold, but possible allele)
            92% to 3A81, 90% to CYP3A81b, 90% to CYP3A81a
            renamed CYP3A82v1, adjacent to CYP3A81
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE

CYP3A123X   Xenopus laevis
            AAH60496.1 GenPept  
            90% to CYP3A82v1, 90% to CYP3A81a, 89% to 3A82, 88% to CYP3A81
            renamed CYP3A81b, presumed ohnolog to CYP3A81a (90%)
            CYP3A81a and CYP3A81b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE

CYP3A124X   Xenopus laevis
            AAH84827.1 GenPept
            89% to 3A83, 89% to 3A120, 88% to 3A121
            renamed CYP3A83a, presumed ohnolog to CYP3A83b (91%)
            CYP3A83a and CYP3A83b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A83, CYP3A120 and CYP3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE

CYP3A125X   Xenopus laevis
            AAI29607.1 GenPept
            94% to CYP3A81 (possible ortholog), 
            90% to CYP3A81b, 90% to CYP3A82v1, 89% to 3A82
            renamed CYP3A81a, presumed ohnolog to CYP3A81b (90%)
            CYP3A81a and CYP3A81b are probable co-orthologs to the
            Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE

CYP3A126    Pimephales promelas (Fathead minnow)
            No accession number
            Roger Meier
            Submitted to nomenclature committee Dec. 29, 2007
            81% to CYP3A65 Danio

CYP3A127   Gobiocypris rarus (a rare minnow)
           GenEMBL EU106659
           Jiayin Dai
           Submitted to nomenclature committee 4/19/2008
           70% to trout CYP3A27

CYP3A128P   horse
            AAWR02042203.1 386095-397052 (+)
            Pseudogene beginning with exon 8, & = frameshift
386095 AVFPFLKPVFEA*NIFLFPKSVLDFFTKSIKx & xKESRHKDKQK (0) 386222
387533 Q*VDFLQMIT & SQNSKDMDTHK (1) 387597
390790 ALSDLELVAQSIIFIFGGYEPTSSNFSFLMYALATHPDVQQKMQEEIDVTFPNK (0) 390951
395473 APPTYEVLIQMKYLDMVINESLRLFPVTFRLERVGKKDV*ISGVFITKGTVVMVPT 395640
395641 FILHRDLELWQEPEEFHPER (2) 395700 
396957 MPMKFGIQGLLQPQKPTVVKVESRDGTACGL* 397052

CYP3A129   horse 
           AAWR02042203.1 (-) strand
           WGS section of NCBI
453729 MNLIPSFSTDTWVLLATILGLLYL (2)
YGTYTHGLFKKLGIPGPTPLPFLGNVLSYRK (0)
GFWDFDKTCFKKYGKIWG (2)
445287 FYDGRQPVLAITDPEMIKTVLVKECYSLFTNRR (0)
PVGPVGILKSSITLSEDEQWKRMRTLLSPTFTSGKLKE (0)
MFPTISQYGDVLVRNLRKEAEKGMPITLKE (2)
440191 FFGAYSMDVITGISFGVNIDSLNNPQHRFVENCKNILKFHFFDPLTILL (1) 440045
ALLPFLSPVLEVLNILVFPVSAIKFFTKSIKTIKESRLKDKQK (0)
QQVDFLQLMINSQNSKEMSRYK (1)
ALSDLELVVQSISFIFAGYETTSSSLSFLTYALATHPEVQEKLQEEIDLAFPNK (0)
APPTYDALLQMDYLDMVLNENLRLFPIAVRLERVCKKNVKINGVFIPKGTVV
MVPNFLLHRDPEFWPEPEEFHPER (2)
FSKKNKDRINPYVYLPFGTGPRNCIAMRFAIMNMKLAVVKLLQNFSFKPCEETQ (0)
IPLKLCNQGLMEPQKPIVLKVEFRDRTVSGP* 420572

CYP3A130P   horse
            AAWR02045041.1
            4 aa diffs to CYP3A93, partial sequence
            this seq is on a small contig and it may continue
            in the downstream region
 7949 MDLIPTFSMETWVLLATSLVLVYL 8020
12115 YGTYTHGLFKKLGIPGPTPLPFFGNVLSYRK 12207
14312 GISNFDRKCFKKYGKMWG 14365

CYP3A131   Felis cattus (cat)
           no accession number
           Hiroki Teraoka
           Submitted to nomenclature committee April 11, 2010
           Sequence 1
           90% to CYP3A132, 77% to CYP3A4 and CYP3A5 human
           90% to CYP3A98 dog

CYP3A132   Felis cattus (cat)
           no accession number
           Hiroki Teraoka
           Submitted to nomenclature committee April 11, 2010
           Sequence 2
           90% to CYP3A131, 77% to CYP3A4 and CYP3A5 human
           90% to CYP3A98 dog

CYP3A133P  Callithrix jacchus (marmoset)
           chr13:38423087-38424514 (-) strand UCSC Browser
           intronless pseudogene
           83% to CYP3A4, 79% to CYP3A7, 76% to CYP3A5, 69% to CYP3A43
           NUCB2 on left, SAP25 on right (human chr7:100,169,913-100,170,791)
           Human CYP3A pseudogene is chr7:99463529-99469880, 700kb away
           CYP3A43 is chr7:99425739-99463621
YGTNSHGLFKKLGILGPTPLPFLGTVLSYRQDFWKFDMECYKKYGEVWGIYDGRQPVLAI
ADPNIIKTVLVKECYSVFANRRSFGPVGFMKSAISIATDDKWKKI*SLLSPIFTSGKLKE &
VPIFAQYGEVLVKNLRREAEKGK &
INMKDIFGAYSMDVITDTSFGVNNNSLNNPQDPFVESTKKLLRFDVSDPFFLSITIFPFL
TPILEALNISVFPRDSTSFLRKSIKRIKESRLKDTHKHRVDFLQLMIDSQNSKETESHKA
LSDLELMAQSIIFIFTGYETTSSSLFFVMYELATHPDVQQKPQEEIDAVLPNKAPATYDT
VLQMEYLDMVVNETLRLFPLAMRLERICKKDVEINGMLIPKGVVVMNPSYALHYDPKYWT
ETEKFLPERFSKNNKDNTDST &
YTSFRTGPRNCIGMRFALMNMVLALIRVLQNLSFKPCKEIQIPLKLCLGGLLQTEKPI
VLKVESRDGTVSG

CYP3A134P   Macaca mulatta (rhesus monkey)
            chr3:46953658-47019448 (-) strand UCSC browser
            Pseudogene between 3A7 and 3A4 syntenic with CYP3A7-de1b2b of human
            Note: the first exon is 65 kb away from the last three and it may
            be an independent pseudogene fragment, but we have kept them together.
LISVSLCRYETHSHGLLKKLRIPGPTPLPFLGTTVSYHQ
APPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKGVEINGMFIPKGVVVMIPT
YVLHHDPKHWTEPEKFLPER (2)
FSKKNKDNIDPYIYTPFGGGPRNCIGMRFALLNMKLALTRVLQNFSFKPCKETQ (0)
IPLKLRFGGIFQPEKPIVLMAESRNGTVSGA

CYP3A135    Ctenopharyngodon idella (grass carp, white amur)
            HQ191278.1
            92% to CYP3A136 Carassius gibelo

CYP3A136    Carassius gibelo (Prussian carp, wild ancestor of goldfish)
            GU998964.1
            92% to CYP3A135, 81% to CYP3A126 Pimephales promelas, 
            78% to CYP3A65 Danio

CYP3A137P   human = CYP3A43-de1b (name conflict with carp)
            GenEMBL NT_007933.10|Hs7_8090  + strand alternate exon 1
            24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214

CYP3A137    Hypophthalmichthys molotrix (silver carp)
            No accession number
            Xiao-Yu Li
            Submitted to nomenclature committee May 18, 2012
            94% to CYP3A135 Ctenopharyngodon idella (grass carp)
            92% to CYP3A127 Gobiocypris rarus (a rare minnow)
            89% to CYP3A126 Pimephales promelas (fathead minnow)
            84% to CYP3A136 Carassius gibelo (Prussian carp)
            82% to CYP3A65 zebrafish

CYP3A138    Cyprinus carpio (common carp)
            No accession number
            Xiao-Yu Li
            Submitted to nomenclature committee March 28, 2013
            94% to CYP3A136 Carassius gibelo (Prussian carp)
            84% to CYP3A137 Hypophthalmichthys molotrix (silver carp)
            83% to CYP3A135 Ctenopharyngodon idella (grass carp)

CYP3A-se1[2]  human = CYP3A54P
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 2
           2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548

CYP3A-se2[5]  human = CYP3A55P
           NT_033967.1|Hs7_34122 chromosome 7 
           3A psuedogene Exon 5
           2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579

mouse Cyp3a fragments of uncertain location

Cyp3a-se3[1] mouse
           NT_039319.1 
           new 3a frag from 1-24 exon 1 + strand
           v in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
           The true location of this fragment is uncertain
14293 MEPV (frameshift) FSSLTGYEWILLAIILVLLYR 14358

Cyp3a-se4[5:6]X mouse
           NT_071157.1|MmUn_71197_30 
           3a exons 5,6, only 3 aa diffs with 3a63-ps
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
           95% to 3a63-ps
549 EFGSVAIMSKAISISKDEECKRYRALLSPTFTSGRLKE 436
356 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 267

Cyp3a-se5[12]X mouse
           NT_071987.1|MmUn_72027_30 3a exon 12
           2kb genomic sequence near exon 12 has best match to 3a41a-de12b
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a41a-de12b
12194 FIKESKGNIHPYIYLPFGNGPRN*IGMRFALLNMKLTLTKVLQNFTFQPCKETQ 12033

Cyp3a-se6[12] mouse
           NT_055698.1|MmUn_55738_30 3a exon 12
           5 aa diffs with 3a58-ps
           identical to 3a11-de9b10b11b12b
           may be the same sequence between 3a44 and 3a11
1226 FSMENKGSIDPYX 1191
1186 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQ 1064

Cyp3a-se7[8:9:10]X mouse
           NT_067897.1|MmUn_67937_30 3a exon 8
           NT_059425.1|MmUn_59465_30 3a exon 10
5160 bp of the genomic sequence was 98.9% to 3a-se12[8:9:10] pseudogene region
The fragment was removed from Genbank. This was probably a poor quality version of 
3a-se12[8:9:10]
5042 FATFFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 4935
4933 IVERTKENCLDSKQK 4889
HQVDFLHLMINAHDNTKDNESHK
979 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLTHHDS*KNLRENDRALPNK 821

Cyp3a-se8[3]X mouse
           NT_070793.1|MmUn_70833_30 
           1 diff to 3a11 exon 3 or 3a63-ps
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
671 GFWKFDMECYKKYGKTWG 618

Cyp3a-se9[8]X mouse
           NT_050947.1|MmUn_50987_30 
           2 diffs to 3a41 exon 9
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
174 HRVDFLQLMMNAHNNSKDKNSHQ 106

Cyp3a-se10[12] mouse
           NT_050917.1|MmUn_50957_30 
           3a exon 12, 3aa diffs to 3a58-ps
521 FSMENKGSIDPYXXXXXX 486
483 NGPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQ 377

Cyp3a-se11[2]X mouse
           NT_074310.1|MmUn_74350_30 3a exon 12 
           2 diffs to 3a16, 3a41 3a44, 3a63
           whole genomic sequence has best match to 3a63-ps pseudogene
           The fragment was removed from Genbank
           This was probably a poor quality version of 3a63-ps
1107 YGTLTQGLFKKQGIPGPKPLPFLGTVLNYYK 1199

Cyp3a-se12[8:9:10] mouse
           NT_056284.1|MmUn_56324_30 
           3a exon 10
           revised to add two more exons 8 and 9
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10] 
(+)31410 MEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10

Cyp3a-se13[9] mouse 
           Between 3a63-ps and 3a41b in UCSC browser
76087 HQVDFLHLMINAHDKTKDKETHK 
identical to exon 9 of Cyp3a44-de9b10b11b and old frag w from map

Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]

CYP3A       sheep
            PIR A60728 (20 amino acids)
            Pineau, T., Galtier, P., Bonfils, C., Derancourt, J. and Maurel,P.
            Purification of a sheep liver cytochrome P-450 from the
            P450IIIA gene subfamily. Its contribution to the
            N-dealkylation of veterinary drugs.
            Biochem. Pharmacol. 39, 901-909 (1990)
            only one amino acid difference with CYP3A24   (L9K)

CYP3A       baboon (Papio sp.)
            Swiss P80056 (20 amino acids) PIR S21176 (20 amino acids)
            Purification of two cytochrome P450 isozymes related to CYP2A
            and CYP3A gene families from monkey (baboon, Papio papio)
            liver microsomes. Cross reactivity with human forms.
            Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
            Eur. J. Biochem. 204, 641-648 (1992)

3B Subfamily

CYP3B1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2213a
6382   MFEFVLFSGTTWALLALFFALLLL 6311 (2)
6232   YGVWPYHHFKKLGIRGPRPLPFMGSTFYYRK 6134 (0)
6052   GIIPFESWCQAEYGDVWG 5999 (2)
       Exon 3 not detected may be in small seq. gap
5469   XFAGPLEDSVSAVKDERWKRIRSTISPCFTSGRLKN 5368 (0)
5259   AFPIVARYADRITKKLEQSNLDEPINVKE 5173 (2)
5069  FLAPYSLDAVTSVSFSVEADSINNPNDPLIVNLKKVFKFNFVVFFLV 4929 (1)
4846   AFFPFCARLFQFLGIDPIPRSSVNYFYNVIKNFKDQHHAD 4727 (bad boundary, 0 expected)
4124 TRGDFLQVLIQSEIPQSEIKSEQDQPPK 4041 (1)
4011  GLTEHEILSQAFIFIFGGYETTTTTLTNVLYGLAINPDVLQVLHKEIDTNIPSD 3850 (0)
3780   APISYEDLMGLQYLDQVLNESQRLYPTAPRLERACKKTVQIHG 3652
3651  LTILEGTIVGIPVHLLHKDPRFWSSPEEFRPER 3553 (2)
3416  FSKDSTEEVNPYAFMPFGLGPRNCVGMRYAILVMKMLIVRLLQSYTVETCKDTM 3252 (0)
3171   IPLEFDWKSQPLKPIKLSFIPRQK* 3097

CYP3B1    Tetraodon nigroviridis (freshwater puffer) 
          82% to CYP3B1 fugu
MLDLWGLSGTTWTLLALFFALFFL (2)
YGIWPYNHFKKLGIPGPGSLPFIGSLFYYRK (0)
GLVPFERWCQEQYGDIWG (2)
LFSGPLDDGVTVVKDERWKRIRSTMSPCFTSGRLKQ (0)
AFPIVARYADRVTKKLEQSDLDKPIDVKE (2)
FLAPYSLDTVTSASFSVEADAINNPNDPIIVNIKKVLKFNFVVLFLI (1)
AFFPFCSRLLSFLGIDPLPRASVNYFYNLIKKLKDEHHADES (0)
VRGDFLQVLIQSEIPQSEIKSEEDQPPK (1)
GLTEHEILSQAFIFIFGGYETTTTTLTNLLYCLAVNPDALETLHREIDANTSGD (0)
APISYEDLMGLQYLDQVLNEAQRLYPTAPRLERMCKKTVQVQGVTIPEGTVVGIPSHLLHKDPRYWSSPEEFRPER (2)
FSKENAEEVNPYAFVPFGLGPRNCVGMRYALLVMKMVIVRLLQSYTVKTCKDTM (0)
IPLEMDWKYQPLKPIKLSFVPRQK*

CYP3B2      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2213b
12175 MFVFMCFSATTWTILVLFSTLLLL (2)
11998 YGHWPYRLFRKNGIPGPMPLPFIGTMWNLLK 11906 (0)
11778 GNMVFDRECQSKYGDVWG 11725 (2)
11412 VFEGRTPVLMVSDPGMIKTILVKECYSVFTNHRVR (0)
11044 IFSGPLETSVFSAKDETWKRMRTSISPCFTSGRLRQ (0)
10847 AFPIIARYADRFIAKLEQTKLEDSTDIKK 10731 (2)
10640 LFGPYSLDVIASSSFSVDADSINNPDDPFIINIKKVLNLNFWLLLIK 10500 (1)
10422 NVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQS 10309 (0)
 9911 IKGDFLHVMIQNEIPQSEIKSDQDQPPK (1)
 8638 GLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKD 8483 (0)
 8391 TPFSYEDLVGFQYLDQVLNESQRLIPTAPALERFCKKTVQIHGLTIPEGTVVAVPVHLL 8215
 8214 HKDPRFWSSPEEFRPER 8164 (2)
      XXXXXXXXX in sequence gap 
      IELGTFMX frameshift
 8001 FGLGPRNCIGMRYAILVMKMILVRVLQSYTVETCKDTM 7888 (0)
 7808 IPLEFDWKLQPTKQIKLRLVPRQK* 7734

CYP3B2    Tetraodon nigroviridis (freshwater puffer) 
          73% to CYP3B2 fugu
MPLPFIGTMLYSINK
NLIFDRECQAKYGDVWG (2)
TFEARMPVLMVTNPEMIKTIMVKECYSAFTNHTD (0)
FFSGPLENSVFVAKDEKWKRMRASISPCFSSGRIKQ (0)
AFPIIARYADRFIAKLSQNLEEATDIKQ (2)
LFGPYSLDVVTSSSFSVDADSINNPDDPFILNVKKILQFKFWVLLIK (1)
SMFPFSSYLFKLLGMELTPRPHCGLFYERHQEIQGDFLHVMIQNEIPESQIKSRQDQPSK (1)
GLTEHEILSQSILFIFGGYDTTSVSITNALYNLAINPDALQTLHKEIDTCLPKD (0)
APISYEDLMGLQYLDQVLNESQRLMPTAIRLERVCKKTVQVEGVTIPKGATVVIPLLLLHKDPRFWSSPEEFRPER (2)
FSKEEVNPYAFMPFGLGPRNCVGMRYALLVMKMVIARVLQIYTVETCKDTM (0)
IPMELDWKFQPVKPIKLSLVPRQK*

CYP3B3      Oryzias latipes (medaka)
            UCSC Browser, chr15:14900678-14906425, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola1
            70% to 3B4, 67% to 3B7, 66% to 3B6, 67% to 3B1
MFFTLLSPTTWTLLALLFALLWLYGTWPHSVFKNLNIPGPKPLPFVGTIFGVRKGLFAFDSECQAKYGDVWGLYDGRSPVLM
VADPEMIKTIMVKECYSVFTNRRETLIPGPFEDGITVVKDDRWKRIRSTISPCFTSGRLKQVFPIVASYADRLLKKLEQTNL
DEPIHVKQFVAPYSLDTVASASFSVEMDSINNSEDPVNVHIQKLFNINFWPFILLMICPFAGRLLNSLNIGMLPKAESDFFL
NIIKKFKDQHKAGESTRQDFLQVMVQSEIPENEIKNEQEQPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHA
MHTLQKEIDANLQKNASFSYEELNDLHYLDQVILESMRVLPTAPRLERGCKKTVEIQGFTIPEGTVVGIPVMNLHKDPRYWS
SPELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLETCKDTLIPLQFDWKFQPLKPIKLKF
VPRKQ

CYP3B4      Oryzias latipes (medaka)
            UCSC Browser, chr15:14910843-14918605, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola2
            69% to 3B6, 70% to 3B3, 68% to 3B5, 66% to 3B7, 64% to 3B1
MFWSWFPGATWTLLALLLTILIFYGLWPYRVFKNLGISGPMPLPFVGTVPQQMKGLFAFNRECQAKYGDVWGLYEGRSPLLM
IADPKIIKTVLVKECYSTFTNRRNVFDDDGPLGNGVAAVKDERWKRIRSTISPCFTSGRLKQVFPFVARYADRLVNKLQKMN
LNEPIDIKQFVAPYSLDVVTSASFSVETDCINNPNDPVNVQAIKATNFNLWPMIIRMIFPLGARLLKHFKFEIIPRSSVDFF
CDVIKKIKDQHNAGKLTRPDFLQVMIESEIPESEVKNKKDEPSKGLTEQEILFQAFSFILGGYETTSTTLSHIFYNLAINPD
AMHTLQEEIDANLQKDVPVSYDKLNGLEYLDQVLCESLRLIPPAPLLDRVCKKTMQINGLTIPEGTVVGIPVHLLHRDPRFW
DSPDLFRPDRFSKENEGALNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLESCKDTLIPIQFNWKFQPLKPIKLK
FVPRKR

CYP3B5      Oryzias latipes (medaka)
            UCSC Browser, chr15:14921023-14926010, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola3
            71% to 3B6, 68% to 3B4, 66% to 3B3, 62% to 3B7, 59% to 3B1
MLFLFSATTWTLLALIFTILLLFGIWPFRIFQNMGISGPMPMPYVGNLLQQGKGFFEFDHECQTKYGDVWGVFEGRQPILMV
ADPEIIKTVMVKECYSAFTNRRNFFEGDGPLTEAVASAKDEKWKRIRSSLSPCFTSGRLKQVFSIVSRYADRLVEKLGETYL
NKAIDIRQFVAPYTLDVVASASFSVDPDCINNPDDPINVQAQKATRFNFLPTILQSIIPFGGRLLKLFKIETLPSANVEFFI
DIIRNLKDQHKTENRPDFLQVLIESEMPDAEIKNSQQQPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMH
TLQKEIDSNLQKNSSISYEDLNGLEYLDQVINESLRLYPVAPRLDRECKMTVETQGFTVPEGMIVGIPVYLLHKDPRFWSSP
ELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRFAVLMMKMIIVRLLQRYSVETCKYTLIPMQFNWMFQPIKPVKLKFVP
K

CYP3B6      Oryzias latipes (medaka)
            UCSC Browser, chr15:14927785-14936321, Apr. 2006 (oryLat1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            ola4
            69% to 3B4, 71% to 3B5, 66 to 3B3, 65^ to 3B7, 61% to 3B1
MFSATTWTLLALFFTVLLLYGVWPYRVFRKLGISGPMPLPFVGNVLQMGRDILSFDRQCLDKYGDVWGVFEGRQPMLMVANP
ELVKAVMVKECYSAFTNRRNFFPEDGPLADGVAVVKDEKWKRIRSSLTPCFTSGRLKQVYPLVARYAENLVKKLGRMNSDEP
IDVRQFVAPYSMDVVASTSFSVDTDCINNPDDPVNVQAQKATNFNFWPVILQTMIPFGDLLLKLLKFETLPRSNVDFFYDLI
KRLRDQHKAGKLTRPDFLQVLIDSEIPQEHVKNEQPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQ
KEIDSNLQNDGSFSYEELSGLEYLDQVLCESMRFFSPTPRLDRECKKTIEIHGVTIPKGTLVAIPVSLLHMDPRFWSSPEIF
RPERFSKENASELNPYAYMPFGLGPRNCVGMRFAVLVMKMVIVRLLQSYSLETCKDTLIPMQYDWQFQPIKPIKLKFVPRKQ

CYP3B7      Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrVI:13967807-13971259, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac49971
            68% to 3B1, 66% to 3B4
MFLFDWFPATSWTLLALFFTLLILYGIWPYRFFKNLGIKGPRPLPFIGTFLHFRKGWLSFDRECQAKYGDVWGNFDARLPVL
MVADPEIIKTVMVKECYSVFTNRRENAVPGPMGDAITAVKDERWKRIRTSLSPCFTSGRMKQVFPIVARYADRLTEKLGGMH
SVPIDVKQFMAPYSLDVVTSASFSVEANSINNPDDPLNVHLKNILNFKLWPVFILMVFPFGARLLRLLKLEMLDRVSVDYFY
DVIKHFKHQHGEDESTRADFLQVMIQNEIPDTDIKSEEDQPSKGLTEHEILSQALIFIFGGYETTSTTLTFLLYNLATNPDA
MRTLQEEIDANIPRDAPIRYEDLLGLQYLDQVLLESQRLIPTAPRLERVCKKTTQVHGLTIPKDTLVGIPVQLLHMDPRFWS
SPELFRPERFSKESGEEVNPYAYMPFGLGPRNCVGMRYAVLTMKTVLVRLLQSYNVETCKDTMIPLEFDWKAQPVQPVKLQF
VPREQ

3C Subfamily

CYP3C1      Danio rerio (zebrafish)
            GenEMBL BC052130.1 dated 10/7/2003
            Also submitted by Don Buhler 10/2/2003
            Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, 
            Chung WG, Buhler DR. CYP3C1, the first member of a new cytochrome 
            P450 subfamily found in zebrafish (Danio rerio).
            Biochem Biophys Res Commun. 2006 Feb 24;340(4):1039-46.
            52% to 3A48, 53% to 3B1 fugu, 51% to 3B2 fugu 52% to 3A49 
            53% to 3A27 trout, 54% to 3A40 Oryzias, 53% to 3A45 trout, 
            54% to 3A56 fundulus, 54% to 3A30 fundulus, 49% to 3A37 chicken, 
            48% to 3A29 pig (47% to 50% to many mammal 3As)

3D Subfamily

CYP3D1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold 600
            Formerly CYP3A47, seq revised 6/18/2010
      MNYLPLFALETWILLITFTCLFVM (2)
      YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
      NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
      IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
      FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQ (1)
      GCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
      EFDFLQHMISTQKNDGIYAVTS
  (1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
      LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
      FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
      IPFKMDPNTFVGPINPIKLRVVRR*

CYP3D1     Tetraodon nigroviridis (freshwater puffer)
           chrUn_random:50263388-50265036
           first 3 exons and last 2 exons in sequence gaps
           68% to CYP3D1 fugu, probable ortholog
MYEFSKPILVVKDPDMLKTILVKECFTHFTNRR (0)
NVGLNGDFYDAVHFAEDDDWRRIRNNVSPFFTTGRIRQ (0)
WFGLMKRQSSRLTSRLQPRAQNEDVVSVKD (2)
FFGPYSINTFTGCLLGVEVDSQLFLKRASNPFKVSIPLFILQ (1)
ACFPVLLPLLKMLGFSVFSGDSFKFVKKVVEKMRADRDGSSHQ (0)
ELDFLQHMTSTQMKAKKDTGNK (1)
GLTDHEIVTQMTVLLAGGHEAVTLVLTLCAYSLATHPQSLRLLQQEVDSTFPDQ (0)
AAVTLEALLQMEYLDGVVSECLR (2)
LYPSNPRLERTAKSTVKISGITIPKDMTVMVPVYALHRDPEHWPQPEEFQPDR (2)

CYP3D1   Large mouth bass
         DQ786407
         David Barber
         Submitted to nomenclature committee 5/21/04
         Clone name CYP3A-b
         Formerly CYP3A69 
         64% to CYP3A47 Fugu
         note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR

CYP3D1      Gasterosteus aculeatus (stickleback)
            UCSC Browser, chrIX:4874663-4879489, Feb. 2006 (gasAcu1) assembly
            Huan Qiu 
            Submitted to nomenclature committee May 30, 2007
            Gac33061
            76% to 3D1 bass (ortholog), 61% to 3D1 Fugu, 
            58% to CYP3A119, 57% to 3A68 bass
MGCLPFFSVETWILLITFICIFVIYGNWTHGIFENLGIPGPKPYTYWGTIGRHNKVYYKDDQQCAEKYGKVWGMYEFRSPML
AVMDPDMLKTILVKQCFTYFTNRRNIRLNGDLYDSVSTVEDDHWRRIRNVLTPSFTSGHIKEMFKIMKHLSSKLTASLQSKA
QNNEVVTIKDYFGAYSVDVMASCAFSVDMDSINNHSSPIIFHASRFFKFPQFVLILQGIFPVLIPLFELLGISFFSPTSTAF
FKTILAKIKAEREGSTHKNSGDFLQSMINSRTANDPSKGEKNKGSLTDHEILTQATMFMVAGYETSATTLAFLAYNLARNPE
VMKRLQEEIDSTFPNKGAVRYEELLQMEYLDSVVNESMRLYPPAGRLDRVAKKTVEIRGITIPKDMIVMIPVYALHRDPDLW
PEPEEFKPDRFSKQNKRSINPYTYLPFGTGPRNCLGMRFALVLVKLALVEVLQNYSFSVCGETEIPLTMDPGGLVGPLNPIK
LKVTTR

CYP3E1      Hypsibius dujardini (water bear, Tardigrade)
            GenEMBL CK326870.1, CF075781
            David Drane
            3clan 38% CYP3A22 pig
            N-term only 
MWLAWLIGIVTALS
AYYIIAARRKFEYWQKKGVPGPRPWPLVGVFVQTVRMGQGFYDVWATKQFGRMFGYFDGS
QPVIAVSDPEMLRSIMVKDFPQFINRRDVDINGPLLEQAVSVLHGQKWKDVRSTLVPTFT
SGRLKQMNGLINECCDNLVSNLEKKADADEEFECQSLFRSVTMDVIASTFFG

CYP3F1    Asterina pectinifera starfish 
          EST DB408526.1 mate = DB394794 (N-term)
          C-term part is 51% to CYP3A4 human
          N-term part is 39% to CYP3A4 human
MELLGFDLSVTWLLIIGFVLIAVWYDWWCHQYFQ
RRGIPVADYIPFFGNILRWRHGVQTTFTEYVKKHGRVVGMYDFRRPVLIITDPDILKNVL
VKNFSSFYNRRKLPLGQKPLNRGLNQLLNEEWKEIRNVITPSFSASKMRLM

VIAKMEYLDMVINESLRMYPPAVIFDRMCNETITYEGLTIEKGVNVFASLWTLHYDEEFW
PNPTKFDPERFSPENKDSIKPCTYMPFGFGPRNCIGMRFALLEAKMALVRVLQQYRFDVC
SETEIPPKLGKTSFLAPKSMKLSAVPRN*

4A Subfamily

CYP4A1      rat
            PIR S21711 (22 amino acids)
            Okita, R.T. and Okita, J.R.
            Characterization of a cytochrome P450 from Di(2-ethylhexyl)
            phthalate-treated rats which hydroxylates fatty acids.
            Arch. Biochem. Biophys. 294, 475-481 (1992)

CYP4A1      rat 
            Aldridge et al. 
            Biochem. J. 306, 473-479 (1995)
            note: identification of far upstream PPAR response element.

CYP4A1      rat
            GenEMBL M14972
            Hardwick,J.P., Song,B.-J., Huberman,E. and Gonzalez,F.J.
            Isolation, complementary DNA sequence, and regulation of rat
            hepatic lauric acid omega-hydroxylase (cytochrome P-450-LA-omega):
            Identification of a new cytochrome P-450 gene family
            J. Biol. Chem. 262, 801-810 (1987)

CYP4A1      rat
            GenEMBL X07259
            Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
            Differential splicing in the 3' non-coding region of rat cytochrome
            P-452 (P450 IVA1) mRNA
            FEBS Lett. 236 (2), 357-361 (1988)

CYP4A1      rat
            GenEMBL M33937 M57718
            Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
            The rat clofibrate-inducible CYP4A gene subfamily I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
            DNA 8, 503-516 (1989)

CYP4A2      rat
            GenEMBL M33938 M57719
            Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
            The rat clofibrate-inducible CYP4A gene subfamily I. Complete
            intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
            exon organization, and identification of a conserved 19-bp upstream
            element
            DNA 8, 503-516 (1989)

CYP4A3      rat
            GenEMBL M33936
            Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
            The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of
            IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
            coordinate and tissue-specific regulation of the CYP4A genes
            DNA 8, 517-525 (1989)

CYP4A4      rabbit
            GenEMBL L04758 (1378bp) PIR S32315 (510 amino acids)
            PIR S32423 (64 amino acids)
            Palmer,C.N., Griffin,K.J. and Johnson,E.F.
            Rabbit prostaglandin omega-hydroxylase (CYP4A4):
            Gene structure and expression.
            Arch. Biochem. Biophys. 300, 670-676 (1993)
            Note: The translation is different from the 4A4 sequence
            in the alignment after AALLG. A frameshift occurs between
            nucleotides 1201 and 1203, with an extra "G" added.  After 1320
            P450 similarity stops.  1320-1378 is an intron sequence.

CYP4A4      rabbit
            PIR JN0089 (20 amino acids)
            Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
            Kubota, I. and Kusunose, M.
            Purification and characterization of two forms of fatty acid
            omega-hydroxylase cytochrome P-450 from rabbit kidney
            cortex microsomes.
            J. Biochem. 108, 544-548 (1990)

CYP4A4      rabbit 
            GenEMBL J02818
            Matsubara,S., Yamamoto,S., Sogawa,K., Yokotani,N.,
            Fujii-Kuriyama,Y., Haniu,M., Shively,J.E., Gotoh,O., Kusunose,E.
            and Kusunose,M.
            cDNA cloning and inducible expression during pregnancy of the mRNA
            for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome
            P-450p-2)
            J. Biol. Chem. 262, 13366-13371 (1987)

CYP4A5      rabbit
            GenEMBL M28655
            Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
            Muerhoff,A.S. and Masters,B.S.
            Cloning and expression of three rabbit kidney cDNAs encoding lauric
            acid omega-hydroxylases
            Biochemistry 29, 873-879 (1990)

CYP4A5      rabbit
            GenEMBL X57209
            Yokotani,N., Kusunose,E., Sogawa,K., Kawashima,H., Kinosaki,M.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            cDNA cloning and expression of the mRNA for cytochrome P-450kd
            which shows a fatty acid omega-hydroxylating activity
            Eur. J. Biochem. 196 (3), 531-536 (1991)

CYP4A6      rabbit
            PIR S23949 (510 amino acids)
            Muerhoff, A.S., Griffin, K.J. and Johnson, E.F.
            Characterization of a rabbit gene encoding a
            clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
            Arch. Biochem. Biophys. 296, 66-72 (1992)

CYP4A6      rabbit
            PIR PQ0047 (20 amino acids)
            Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
            Purification and characterization of two forms of cytochrome
            P-450 with omega-hydroxylase activities toward
            prostaglandin A and fatty acids from rabbit liver
            microsomes.
            J. Biochem. 107, 280-286 (1990)

CYP4A6      rabbit 
            GenEMBL M29531 J05150
            Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            Two forms of omega-hydroxylase toward prostaglandin A and laurate:
            cDNA cloning and their expression
            J. Biol. Chem. 264, 21665-21669 (1989)

CYP4A6      rabbit
            GenEMBL M28656
            Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
            Muerhoff,A.S. and Masters,B.S.
            Cloning and expression of three rabbit kidney cDNAs encoding lauric
            acid omega-hydroxylases
            Biochemistry 29, 873-879 (1990)

CYP4A6      rabbit
            GenEMBL L04755
            Muerhoff,A.S., Griffin,K.J. and Johnson,E.F.
            Characterization of a rabbit gene encoding a clofibrate-inducible
            fatty acid omega-hydroxylase: CYP4A6
            Arch. Biochem. Biophys. 296, 66-72 (1992)

CYP4A7      rabbit
            PIR JN0090 (20 amino acids)
            Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
            Kubota, I. and Kusunose, M.
            Purification and characterization of two forms of fatty acid
            omega-hydroxylase cytochrome P-450 from rabbit kidney
            cortex microsomes.
            J. Biochem. 108, 544-548 (1990)

CYP4A7      rabbit
            GenEMBL M29530 J05150
            Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            Two forms of omega-hydroxylase toward prostaglandin A and laurate:
            cDNA cloning and their expression
            J. Biol. Chem. 264, 21665-21669 (1989)

CYP4A7      rabbit
            GenEMBL M28657
            Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
            Muerhoff,A.S. and Masters,B.S.
            Cloning and expression of three rabbit kidney cDNAs encoding lauric
            acid omega-hydroxylases
            Biochemistry 29, 873-879 (1990)

CYP4A8      rat
            PIR S08300 (15 amino acids)
            Imaoka, S., Nagashima, K. and Funae, Y.
            Characterization of three cytochrome P450s purified from
            renal microsomes of untreated male rats and comparison with
            human renal cytochrome P450.
            Arch. Biochem. Biophys. 276, 473-480 (1990)

CYP4A8v1    rat
            GenEMBL M37828
            Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
            Cloning and characterization of a novel member of the cytochrome
            P450 subfamily IVA in rat prostate
            DNA Cell Biol. 9 (8), 569-577 (1990)

CYP4A8v2    rat
            UCSC browser 
            This is the best match to M37828, but there are some differences
            especially in exon 6 (9aa diffs)
97% TO 4A8v1 M37828 chr5:135553023-135583411 (- strand) BC081771
CK483390.1 AGENCOURT EST matches
135583411 MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHK 135583223 (0)
135581811 IPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRS 135581671 (1)
135581054 DPKSHHSYRFLAPWI 135581010 (1)
135580577 GYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIML 135580449 (0)
135558913 DKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDR 135558788 (2)
135558475 KYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 135558323 (1)
135557899 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135557792 (0)
135557703 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135557512 (2)
135557411 DDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPK 135557280 (1)
135556361 GITVMLSFYGLHHNPTVWPNPE 135556296 (0)
135556143 VFDPYRFAPESSRHSHSFLPFSGGAR 135556066 (2)
135553187 NCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ 135553023

CYP4A8v2-de1b  rat
            UCSC browser
CYP4A exon 1 pseudogene chr5:135545150-135545338 (- strand)
Frag a in fig. below
135545338 MSIFELSHITTGFGISGLLQMVSWLGLLLLLLFKAAQYYLHRQWIIKSVQHFPSPPSHWFFGN 135545150
human, mouse and rat 4ABXZ clusters

CYP4A8v2-de5c6c12c  rat
            UCSC browser (upper line is the new sequence)
135596695-135596537 (- strand) C exon 5
Frag b in fig. below
Query: 37481 SVLLPQNKWE*TISDS---LEIFQCASLITLATILMCVFSY*DNVHLNRSVTSQSF 37639
             SV +  +KWE  + D    LEIF   SL+TL T++ C FS+  +V L+  V S+S+
Sbjct:   159 SVSIMLDKWE-KLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 211

135596212-135596066 (- strand) D exon 6
Query: 37964 HSQTYTQVVGILNNL-----RNAFPQSDIFYRMTADGHRTKNAFLIAHKHSDFV 38110
             +S++YT+ V  LNNL     R+AF  + I Y M++DG  ++ A  IAH+H+D V
Sbjct:   207 NSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGV 260

135594009-135593884 (- strand) E exon 12
Query: 40167 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 40292
             KQF MNE+KV + LTLL FE L DPTR+ V +   +L  + G
Sbjct:   454 KQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNG 495
human, mouse and rat 4ABXZ clusters

CYP4A8v2-de4d12d  rat
            UCSC browser (upper line is the new sequence)
135628319-135628215 (- strand) A exon 4
51% to 4A8 
Frag c in fig. below
Query:  5857 LSNDQTWFQHY*HI*TPLLHCDILKSNVRIVADCI 5961
             L N + WFQH   + TP  H DILK  V+I+AD +
Sbjct:   127 LLNGKKWFQHR-RMLTPAFHYDILKPYVKIMADSV 160

135617441-135617274 (- strand) B exon 12
75% to 4A2 76% to 4A8 
Query: 16735 RICIGKQLAMNAQKLAVALTLLQFELLPDPTRVPIPTEKLVLKSKNGIHLHLRKLQ 16902
             R CIGKQ AMN  K+AVALTLL+FELLPDPTR+P+P  +LVLKSKNGIHL L+KL+
Sbjct:   449 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR 504
human, mouse and rat 4ABXZ clusters

Cyp4a10     mouse
            GenEMBL X69296 (1887bp)
            Colin J. Henderson, Theo Bammler & C. Roland Wolf
            Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a 
            protein: developmental and hormonal regulation in liver and kidney
            Biochim. Biophys. Acta (1994) 1200, 182-190

Cyp4a10     mouse
            GenEMBL X71478 (129bp) PIR S35608 (43 amino acids)
            Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
            Species-specific induction of cytochrome P-450 4A RNAs: PCR 
            cloning of partial guinea-pig, human and mouse cDNAs.
            Biochem. J. 294, 173-180 (1993)

            GenEMBL Y10221 (exons 10-12)
            Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
            Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
            A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans.
            Biochem. J. 325, 741-749 (1997)
            Chromosomal assignment of this gene is given.

Cyp4a10     mouse
            GenEMBL AB018421
            Yasumura,N. and Ikeda,T.
            Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse
            Unpublished (1998)

Cyp4a10     mouse
            GenEMBL NT_039264.1 + strand
15663999 MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHE 15664187
15665307 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS 15665450
15665928 DPKANGAYRLLAPWI 15665972
15666744 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLML 15666872
15669925 DKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVD 15670047
15670403 NYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHT 15670555
15670978 DGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFAR 15671085
15671175 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITW 15671366
15671463 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPK 15671594
15674911 GVQVTLSIYGLHHNPKVWPNPE 15674976
15675119 VFDPSRFAPDSPRHSHSFLPFSGGA 15675193
15678206 RNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH* 15678376

CYP4A11     human
            GenEMBL L04751 (2576bp)
            PIR S29845 (519 amino acids)
            Palmer,C.N., Richardson,T.H., Griffin,K.J., Hsu,M.-H.,
            Muerhoff,A.S., Clark,J.E. and Johnson,E.F.
            Characterization of a cDNA encoding a human kidney,
            cytochome P450 4A fatty acid omega-hydroxylase and the
            cognate enzyme expressed in Escherichia coli.
            Biochim. Biophys. Acta 1172, 161-166 (1993)

CYP4A11     human
            GenEMBL X71480 (423bp) PIR S35609 (141 amino acids)
            Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A., 
            Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
            Species-specific induction of cytochrome P-450 4A RNAs: PCR 
            cloning of partial guinea-pig, human and mouse cDNAs.
            Biochem. J. 294, 173-180 (1993)

CYP4A11     human
            GenEMBL S67580 (2470bp) and S67581 (2469bp)
            Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
            Complete cDNA sequence and cDNA-directed expression of
            CYP4A11, a fatty acid omega-hydroxylase expressed in human
            kidney.
            DNA Cell Biol. 12, 893-899 (1993)

            GenEMBL NM_000778
            Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
            Complete cDNA sequence and cDNA-directed expression of CYP4A11, a
            fatty acid omega-hydroxylase expressed in human kidney
            DNA Cell Biol. 12, 893-899 (1993)

CYP4A11     human
            GenEMBL D26481 (2382bp) PIR JX0331, PC2194 (519 amino acids)
            Kawashima,H., Kusunose,E., Kikuta,Y., Kinoshita,H., Tanaka,S.,
            Yamamoto,S., Kishimoto,T. and Kusunose,M.
            Purification and cDNA cloning of human liver CYP4A fatty acid
            omega hydroxylase.
            J. Biochem. 116, 74-80 (1994)

CYP4A11     human kidney
            GenEMBL D13705 (1809bp)
            Kikuta,Y.
            unpublished (1994)
            P-450 HVK, fatty acid omega hydroxylase

CYP4A11     Pan troglodytes (chimp)
            missing some internal seq. and the N-term
            DQ037004.1
MKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMAD SVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDL NNLVFXXXRNAFXXNDTIYSLTSAXXWTHRACQLAHXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ ERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALXXYPXXPGXXXXXXXXXXXXXXXX XXXXIMVFLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSXXXXXXXXAM NELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

CYP4A11     Macaca fasicularis (cynomolgus monkey)
            DQ074797
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP4A11_24C2
            95% to CYP4A11 human 92% to 4A22
MSVSVLSPSRLLGSVSGILQVTSLLILLLLLIKAAQLYLHRQWL
LKALQQFPCPPSHWFFGHFQKFQQDQELQRIRKWVEMFPSACPLWLWGGKVRVQLHDP
DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVA
LMADSVRVMLDKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRDSQSYI
QAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHTDQVIQLRKAQLQK
EGELEKVKRKKHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL
YALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGISRE
LSTPVTFPDGRSLPKGIAVMLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF
SGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRR
LPNPCEDKDQL

CYP4A11     Macaca mulatta (rhesus monkey)
            94% to human 4A11 
MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLFGHKQE (0)
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS (1)
DPKSQDPYRFLAPWI (1)
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML (0)
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR (2)
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT (1)
DQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK (0)
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW (2)
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK (1)
GITVMLSIYGLHHNPKVWPNPE (0)
VFDPSRFAPGSAQHSHAFLPFSGGSR (2)
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

Cyp4a12a    mouse
            no accession number
            Jorge Capdevila
            submitted to nomenclature committee 12/4/96 fax
            complete sequence 4aVJ2 
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
MKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIM
ADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
VEDLNDLVFSRVRNIFHLNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEE
ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
LATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKELQ

Cyp4a12a    mouse
            GenEMBL Y10222 (exon 12)
            Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
            Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
            A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans.
            Biochem. J. 325, 741-749 (1997)
            Chromosomal assignment of this gene is given.

Cyp4a12a    mouse
            GenEMBL X71479, Y10222 EST AA882070 vx36a01.r1 no UNIGENE entry
            NT_039264.1
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHK
ILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRS
DPKANGSYRFLAPWIG
RGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVML
DKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRK
YKSYIQAVEDLNDLVFSRVRNIFH(Q)NDIIYRVSSNGCKANSACKLAHDHT
DQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFAR
MENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITW
NDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKG
IHVMLSFYGLHHNPTVWPNPE
VFDPSRFAPGSSRHSHSFLPFSGGA
RNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ*

Cyp4a12a-de5b mouse
           GenEMBL NT_039264.1 + strand, exon 5 
           x in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15432755 NKWE*NISDSLEIFQCASLITLATIIMCAFSYQDNVHLNRSVTYIKWVRKL 15432907

cyp4a12b    mouse
            GenEMBL X71479 (423bp) PIR S35610 (141 amino acids) NM_172306
            Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
            Species-specific induction of cytochrome P-450 4A RNAs: PCR 
            cloning of partial guinea-pig, human and mouse cDNAs.
            Biochem. J. 294, 173-180 (1993)
            PCR fragment
NM_172306 97% identical to Cyp4a12a 11 diffs
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
MKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIM
ADSVRVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
VEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEE
ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
LATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ

Cyp4a12b-de2b5b mouse
           GenEMBL NT_039264.1 + strand
           exons 2,5 
           w in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15541025 LLVYDPD*VTLILGRA 15541072
15544976 NKWE*NISDSLEIFQCASLITLATIIMCAFSYQDNVHLNRSVTYIKWVRKL 15545128

CYP4A13     Cavia cobaya (guinea pig)
            GenEMBL X71481 (423bp)
            PIR S32714 (141 amino acids) PIR S35611 (141 amino acids)
            Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
            Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
            Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
            Species-specific induction of cytochrome P-450 4A RNAs: PCR 
            cloning of partial guinea-pig, human and mouse cDNAs.
            Biochem. J. 294, 173-180 (1993)

Cyp4a14     mouse
            GenEMBL Y11639 to Y11642 exons 1-12
            Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
            Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
            A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
            and Cyp4b, but not of CYP4F, genes in mouse and humans.
            Biochem. J. 325, 741-749 (1997)

Cyp4a14     mouse
            no accession number
            Jorge Capdevila
            submitted to nomenclature committee
            complete sequence

Cyp4a14     mouse
            GenEMBL NT_039264.1 - strand also Y11638 NM_007822
15641790 MGFFLFSPTRYLDGISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGH 15641605
15640707 LFPKDKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRS 15640564
15639891 DPKASGIYQFFAPWI 15639847
15639380 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIML 15639252
15638411 DKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLD 15638289
15637911 NSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHT 15637759
15637345 DGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFAR 15637238
15637154 MEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVT 15636966
15636875 DHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPK 15636744
15635704 GITATISIYGLHHNPRFWPNK 15635639
15635542 VFDPSRFAPDSSHHSHAYLPFSGGS 15635468
15632990 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKKLR* 15632820

CYP4A15     Phascolarctos cinereus (koala) 
            AF463456
            Ieva Stupans
            Submitted to nomenclature committee Oct. 20, 1999
            69% identical to human 4A11
MNSPLSFAWFQGNVSGLLQVSFLLGLGLLVLKVAQMYVRRQRLL
RDFQNFPGPPSHWLYGNTLEFPVEEELPKMASLAEKFPCAFPRWLTGSWNLLQVYDPE
YMKLILSKRDPKSHDVYKFLIPWIGKGLLVLNGSDWFRHRRLLTPAFHSDILKPYVGL
MADSARVMLDKWEKLSYQPLSLEISEHVSLMTLDSLMKCAFSHQSNCQMDRHSNLYIQ
AVHDLSYLLSSRMRNAFYHNDVLYWFSSAGRRTREAAQRAHQYTDQVIQRRRQQLEQE
GGLEAISRKRHLDFLDILLCARTEGGDSLLDEELRAEVDTFMFEGHDTTASGISWLLY
ALATHPEHQQKCREEIRGVLGDGTSITWDHLGQLPYTTMCIKEALRLYPPVPSIGRDI
KETITFPDGRILRAGNSVSLHIYALHHNPRVWENPEVFNPFRFSPENLTLQHSHAFLP
FSAGSRNCIGQKFAMNEMKVVLALTLLLFELKPDTMKPPLPISKLVLKSK

CYP4A16     Felis cattus (domestic cat)
            GenEMBL U91787
            Gebremedhin,D.G., Lange,A.R., Narayanan,J., Aebly,M., Jacobs,E. and
            Harder,D.R.
            Cerebral vascular smooth muscle cells express cytochrome P450 4A2
            enzyme and produces 20-HETE which enhances L-type calcium current
            Unpublished

CYP4A17     hamster
            No accession number
            David Bell
            Submitted to nomenclature committee 12/1/99
            170 amino acid C-terminal fragment from I-helix to heme
            Clone name 4ai 90% to mouse Cyp4a10 95% to 4A19

CYP4A18     hamster
            No accession number
            David Bell
            Submitted to nomenclature committee 12/1/99
            170 amino acid C-terminal fragment from I-helix to heme
            Clone name 4aii 88% to rat CYP4A1 88% to 4A19

CYP4A19     hamster
            No accession number
            David Bell
            Submitted to nomenclature committee 12/1/99
            170 amino acid C-terminal fragment from I-helix to heme
            Clone name 4aiii 92% to rat CYP4A1 95% to 4A17

CYP4A20X    human 
            GenEMBL AJ131016 AC026935 161971-176942 
            Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
            Full length seq now available on genomic DNA
            52% to 4A11 52% to 4X1 
            because the sequence is the same percent identity to
            4A11 and 4X1 and this is less than 55% 
            and the sequence does not cluster with CYP4As on a tree
            the earlier name of CYP4Z1 is being resurrected.
            This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDRS
SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
HLEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV

CYP4A21     pig 
            GenEMBL AJ278474 
            Lundell K, Hansson R, Wikvall K.
            Cloning and expression of a pig liver taurochenodeoxycholic acid 
            6 alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily.
            J Biol Chem. 276, 9606-12 (2001)
            77% to rabbit 4A6
            submitted to nomenclature committee July 3, 2000
            This enzyme catalyzes a 6alpha-hydroxylation of chenodeoxycholic acid

CYP4A21     pig 
            NM_214425, AJ586859
MTVPALASVSGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSEPKAPVLYRLLIPWIGCGLLLLNGQMWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSQSYIQAIWDL
KNLIFSRLRSAFLQNDIIYRLSPEGRQCQRACQKVHQHTDRVIQLRKTHLQKEGEMEN
VKKKRHLDFLDILLFARMENGNSLSDTDVRAEVDTFMAAGHDSTASGISWVLYALASN
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPSVGRELSKPIT
FPDGRSLPAGIILSLSIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVVVALTLLRFELAPDPSRIPVPIQGIVLKSKNGIHLNLRKIP

CYP4A22       human
              GenEMBL AL390073.5, AF208532 AL135960 all genomic sequences
              new 4A11 like genomic sequence 95% identical to 4A11 
              three different gene sequences agree 
              so this gene is different from 4A11
MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQE
FQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYKFLAPRI
GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDR
NSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG
IMVLLSIYGLHHNPKVWPNLE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL*

Also AF208532
Homo sapiens fatty acid omega-hydroxylase CYP4A11 like gene, complete cds
CDS             join(2564..2758,5858..5999,6649..6693,7186..7313,
                     8347..8471,8840..8994,9435..9541,9628..9818,9915..10048,
                     10944..11008,11155..11231,13680..13875)

also AL135960 matches new 4A gene not 4A11 gene
Human DNA sequence from clone RP1-18D14 on chromosome 1 Contains genes for SIL (TAL1
 (SCL) interrupting locus ), TAL1 (T-cell acute lymphocytic leukemia 1), 17 KD membrane associated protein (DD96 protein), CYP4A11 -like gene
gi|6635875|emb|AL135960.1|AL135960[6635875]
CDS             complement(join(129154..129349,131798..131874,
                     132021..132085,132981..133147,133211..133401,
                     133488..133594,134035..134189,134558..134682,
                     135716..135843,136336..136380,137030..137171,
                     140271..140465))

CYP4A22    Pan troglodytes (chimpanzee)
           XM_513388.3
           98% to human
MSVSVLSPSRLLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWL                      LKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDP                      DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVG                      LMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYI                      QAISDLNSLVFCRMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQK                      EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL                      YALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE                      LSTPVTFPDGRSLPKGIMVFLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF                      SGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRR                      
LPNPCEDKDQL

CYP4A22   Macaca mulatta (rhesus monkey)
          AC203029.4
          ortholog (first two exons then a seq gap in genome assembly) 
          AC203029.4 has all of it with a perfect match to the first two exons.
          97% to 4A11 rhesus, 94% to human 4A11, 92% to human 4A22 
          syntenic with 4A22 human
MSVSVLSPSRLLGSVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWFFGHFQK
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS
SDPKSHGSYRFLAPWIG
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT
TDQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK
GITVMLSIYGLHHNPKVWPNPE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL

CYP4A23     pig
            GenEMBL AF384031
            Van Es,A., Calleja,C. and Galtier,P.
            Cloning of a new member of the cyp4a subfamily in the pig renal
            cell line LLC-PK1
            Unpublished
            Note: CYP4A23, 24 and 25 are all on the border of being alleles of the same gene

CYP4A23     pig 
            NM_214424.1
MTVPALASVSGPLQVASLLGLLLLLLKAAQLYLHRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELPPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSDPKTSVVYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSVQTDGDSHSYIQAIWDL
KNLFSTRTKSAFLQNDIIYRLSPEGHKNHRAARIAHQHTDRVIQLRKAQLQKQGEMEN
VRKKRHLDFLDILLLAQMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASH
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPIT
FPDGRSLPAGIILSLFIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVAVALTLLRFELAPDPSRKPIATPEVVLNSKNGIHLKLRKLP

CYP4A24     pig 
            GenEMBL AJ318096
            Kerstin Lundell 
            97% to pig 4A25, 97% to pig 4A23 AF384031, 90% to pig 4A21 AJ278474 
            77% to rabbit 4A6, 75% to human 4A11
            submitted to nomenclature committee June 12, 2001
            Note: CYP4A23, 24 and 25 are all on the border of being 
            alleles of the same gene

CYP4A24     pig  
            AJ586619, NM_214424
MTVPALASASGLLQVASLLGLLLLLLKAAQLYLHRQWLLKALQQFPSPPSHWLYGHSREFQEESELPPLLKRVEKYPSACALWRWGTRAMVLVYDPDYMKVVLARSDPKNSVVYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDLKNLFSIRTKSAFLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMENVRKKRHLDFLDILLLARMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPITFPDGRSLPAGITLSLSIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRNCIGKQFAMNEMKVAVALTLLRFELAPD

CYP4A25     pig 
            GenEMBL AJ318097
            Kerstin Lundell 
            97% to pig 4A24, 96% to pig 4A23, 91% to pig 4A21, 78 % to rabbit 4a6, 
            75% to human 4A11
            submitted to nomenclature committee June 12, 2001
            Note: CYP4A23, 24 and 25 are all on the border of being 
            alleles of the same gene
MTVPALASASGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSEPKAPVLYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDL
KNLFSIRTKSAFLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMEN
VRKKRHLDFLDILLLARMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASH
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPIT
FPDGRSLPAGIILSLSVYSLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVAVALTLLRFELAPDPSRKPTVIPEVVLHSKNGIHLKLRKLP

CYP4A26P    human = CYP4A-se1[12]
            AL731892.5 
            76% to 4A11 C-term upstream of 4A11
            TCIGKKFAMNEL 135092
            135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
            NT_04852.13 - strand
7968299 TCIGKKFAMNELKVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRVPNHCGDKDQL* 7968105

CYP4A27P    human = CYP4A-se3[12]
            AL731892.5 
            67% to 4A11 C-term
           168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
            NT_04852.13 - strand exon 12
8001510 NCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRLPNTCEDKNQI* 8001322

Cyp4a28p    mouse
            AJ297131 also on NT_039264.1, NT_039685.1
            lower case = 4a10, same contig as 4x1
4.112000001-113000000 from Ensembl mouse version 3 chr 4 add 112 million to numbers
943832 MSISALSPTRFLECVSGFLQVVSLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 943647 
939707 QFKEDEELRWVLRYVEKFPSAFLHWIWGN 939621 frameshift
939621 *VFIKIYDPDYMKVILGRA 939565                                   
939009 SDPKAGLYRFLTPWL 938965                                          
938111 GHGLFILNGHKWFQHRRMLTSAFHYDILKPYVGTMADSVQVIL 937983               
930960 DKWEQIACQDITLEIFHPISLMMLETIMKCAFSYQGSVQLDRS 930832               
930514 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 930359      
929925 DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 929809        
       DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 929542 
       EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 929424
(missing exon 10)
927997 VFDPSRFAMNSVQHSHAFLPFSGGS 927923                               
926387 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHL 926238        

exact duplicate of exons 6-12
925899 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT
       DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 925195
       DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 924927 
       EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 924809
923831 IESTVSCFIFSSAWKAFDKPE
923372 VFDPSRFAMNSVQHSHAFLPFSGGS 923298                               
922002 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHLHLRKL 921838   

Cyp4a29    mouse
4.113000001-114000000 chr 4 from mouse Ensembl version 3 add 113 million to numbers
91% to 4A28p
47095 MSISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 47280 
53123 QFKVDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRA 53266          
53824 SDPKASLYRFLTPWL 53868                                           
54675 GHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVML 54803
55849 EKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRS 55977                 
56295 RSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 56450        
56880 DRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRVSS 56996
57075 DDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITW 57263 
57362 DHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKG 57378
58567 IESTVSCFIFFSAWKAFDKPE
59045 VFDPSRFAMNSVQHSHAFLPFSGGS 59119                                 
60585 RNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHLRKL 60749     

Cyp4a29-de5b6b7b9b  mouse
           GenEMBL NT_039264.1 + strand
           old temp name = Cyp4azzp 
           y in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15364293 QWEKII**DTTLEIFHHVSLMMLNTIIKCAFCYQGSVPLDRS 15364418
15364782 RNFQSYLQAVSYLNSIKSFCMLNLFQQNSYKLSSDGHRANCACQTVRKY 15364928
15365362 TD*VIKMRKAQQSKGSMEKLRGKR 15365433
15365704 FVGSSLLRNCIEKQLAMNVLKMDAALTLLGFD 15365799

Cyp4a29-de12b mouse
           GenEMBL NT_039264.1 Cyp4axxp + strand 
           78% to 4a29
           old temp name = Cyp4axxp
           z in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15321475 KNCIVKQIAMNTLKVAVALTLLQFERLPDPTRVPIPTLQLVLI 15321603
15322479 SKNAIHLHLRKLQ* 15322520

Cyp4a30a-ps mouse
           GenEMBL NT_039264.1 + strand
           old temp name = Cyp4aaab 
           missing exons 1-4
15489465 DKWEQLVGQDCPLEIYQDISLMTMETIMKCAFSYQGSVQLE 15489587
15489953 NSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHT 15490105
15497986 ERVICMRKAQLQNEAELEKVRKKKHLDFLDILLFAQ 15498093
15498179 TEDGKSLSDEDVRAEVDTFRFEGHDTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVTW 15498370
15498472 NYLDQMPYTTMCIKEALRLYPPIPGVSREFSSPVTFPDRRSLPK 15498603
15500524 GFLVTLSFYGLHHNPRLWPNAE 15500589
15500709 VFDPSRFAPGAPWHTHAFLPFSAGTR 15500786
15508625 RNCIGKQFTMNELKVAVALTLLRFELLPDPTSVPILVLRIVLKSKNGIYLHIKKL 15508789

Cyp4a30b   mouse
           NT_039264.1 + strand 94% to Cyp4a30a-ps
           old temp name = Cyp4aaa, also old 4ayy frags belong to this gene
           LOC230640 from mouse genome 
           68% to 4a10
   1 MSIFELSHITNVFGIFGLLQVVSLLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWLFGN 189
1729 XFPKDQDLQQILLCVEKFPSTYVRWLWGNHARVVIYDPDYMKVILGRS 1869
2385 DPKVVRSYSFFAPWI 2429 
4002 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVML 4130
5130 DKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSVQLE 5252
5617 NSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSS 5721 
5723 NGRSFYHACQIAHKHT 5770
6175 ERVIRMRKAQLQNEAELEKFRKKKRLDFLDILLFAQ 6288
6374 TEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVT 6562
6666 NHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDGCSLPK 6797
8724 GFLVTLSFYGLHHNPRLRPNAE 8789
8903 VFDPSRFAPGAPRQTHAFLPFSAGTR 8986
18305 NCIGKQFTMNELKVAVALTLLRFELLPDPTRVPILVSKIVLKSKNGIYLHTKKL 18472

Cyp4a31    mouse
           GenEMBL NT_039264.1 + strand
           old temp name = Cyp4abb 
15709394 MSVSALSLTRFAGSLSGFLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHE 15709582
15710687 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS 15710830
15711347 DPKANGAYRLLAPWI 15711391
15712156 GYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLML 15712284
15715386 DKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDx 15715508 (g)
15715864 NYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQACQLAHDHT 15716016
15716439 DGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFAR 15716546
15716635 MENEDSMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITX 15716823
15716923 DHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPK 15717054
15720376 GVQVTLSIYGLHHNPKVWPNPE 15720441
15720567 VFDPSRFAPDSPRHSHSFLPFSGGA 15720641
15723611 RNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMSLARFVLKSKNGIYLHLKKVH* 15723781

Cyp4a32    mouse
           GenEMBL NT_039264.1 + strand
15746652 MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRKWLLKALQQFPSPPFHWFFGHE 15746840
15747937 QFKGEQELKEVVSCIEHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRS 15748080
15748604 DPKANGIYRLLAPWI 15748648
15752321 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLML 15752449
15755304 DKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDX 15755426
15756131 NYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHT 15756283
15756698 DGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFAR 15756805
15756894 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITW 15757085
15757182 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPK 15757313
15760289 GVQVTLSIYGLHHNPKVWPNPE 15760354
15760497 VFDPSRFAPDSPRHSHSFLPFSGGA 15760571
15767109 RNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHLKKLH* 15767279

CYP4A33P  rat
          UCSC browser exons 5-12
135689623 DKWEQIVGQDSTLEIVQHNTLMTLDTIMKCAFSQEGSVQLDR 135689766
135690074 KYKSYIKAVGDLNNLSFFRIWNIFHQNDIIYSLSSNGCQANSAC*LAHEHT 135690238
135690647 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135690760
135690855 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135691046
135691147 DDLDKMPYTTMCIKEALSIYPPVPSVSRMLSTPVTFPDGCSLPK 135691278
135692145 PKGITAVLSFYGHHHNPTL*PNPE 135692213
          VFDPYRVFPXSSQHSHLFLPFSGGAR 135692425
135700661 NCIGKQFAMNELKVAIALTLLCLRLLPDPTRIPIPIPRLVLKSKNGIYLHLKKLQ 135700825

CYP4A33P-de4b5b12b  rat
            UCSC browser (upper line is the new sequence)
            frag d in fig. below
135662099-135662209 (+ strand) F exon 4
Query:  9457 LSNDQTWFQH*HILTPLFHYGILKTNVRIIVDSVHEM 9347
             L N + WFQH  +LTP FHYGILK  V+I+ DSV+ M
Sbjct:   130 LLNGKKWFQHRRMLTPAFHYGILKPYVKIMADSVNIM 166

135671387-135671512 (+ strand) G exon 5
Query:   169 DISDSLEIFQCASLIALATIMMCAFSYQDNVHLNRSVTSQSF 44
             D    LEIF   SL+ L T+M CAFS+Q +V L+  V S+S+
Sbjct:   175 DQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 214

135676914-135677039 (+ strand) S exon 12
Query: 93402 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 93277
             KQF MNE+KV + LTLL FE L DPTR+ + I   +L  + G
Sbjct:   458 KQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNG 499
human, mouse and rat 4ABXZ clusters

CYP4A33P-de10c11c  rat
            UCSC browser (upper line is the new sequence)
            frag e in fig. below
135712750-135712827 (+ strand) exon 10
Query: 57566 GVLISFSICGLHHNPRLWPNAEV*NP 57489
             G+ +  S  GLHHNP +WPN EV +P
Sbjct:   406 GITVMLSFYGLHHNPTVWPNPEVFDP 431

135713048-135713125 (+ strand) R exon 11
Query: 57271 QVFDPFRFAPDVLRHTHAFLPFSAGAR 57191
             +VFDP+RFAP+  RH+H+FLPFS GAR
Sbjct:   427 EVFDPYRFAPESSRHSHSFLPFSGGAR 453
human, mouse and rat 4ABXZ clusters

CYP4A34P rat
            UCSC browser 
new pseudogene seq between 4A3 and 4A2 T
65% to 4A2 135837702-135845966 (+ strand)
MGIFELSHITTVFGISRLLQMVFWLGLLLLLFKAAQYYLRRQWIIKSFQQFPFPPSHWLFGNFLK
135838759 KDQDLQQIRLWVEKFPTACVRWFWGNHACVLIYDPD*MKVILG*S 135838887 aa 65-107
(exon 3 in a seq gap)
GYSLLLLNGKKWFQHRQMLTPAFHSDILKPYVGIMA
FSIFLLQDKWEELVGQDCPLEIYQDISLMTMETLINCAFSYQGSVQLE
NSRS*IKAVEDLTHLIHFRVRNGFH*SNIIYNLSSNGGSFHCACQIAHKHKG
DRVIRRRKVQLQSGVELEKIWKKWHLDLLDILLFAQ
EDGKSLSDEDLHAEVDTFMFEGHDTAARGISWIFYALPTHPEHQERCKEEVQSILGDGTSVTW
DHLDQMPYTTMCIKKALRLYPPGPAVSRELSTPVTFPDGCSSPKNSRISVV
IFGLHHNPRL*PNPE
VLDPFRFAPDVPQHTHAFLPFSAGAR
NCIRKLFAMNELKVAVTLTLL*LELLPDPTRVPFLVARTVLKSKIRIYLHLKKLK

CYP4A34P-de12b  rat
            UCSC browser 
C-term aa 453-508 with one frameshift
frag f in fig. below
This may be the C-term of a full gene with the rest in a seq gap
135831318 RNCIGEHFAMNELKVAMALTLL 135831383 
135831383 QFELLPDPTRIPIPIPRLVLKSKNGIYLHLKKLQ 135831484
human, mouse and rat 4ABXZ clusters

CYP4A35    Balaenoptera acutorostrata (Minke whale)
           AB290011
           Iwata Hisato
           submitted to nomenclature committee 1/6/05 
           81% to CYP4A11 human
MSVSVLSPTRALGGVSGLLQVASLLGLVLLLLKAAQLYLHRQWL
LKALQQFPSPPSHWLYGHMQEFQEETELRPLLKRVEKYPSACARWLWGTKALVLVYDP
DYMKVVLGRSDPKSHDSYRLLIPWIGNGLLLLERQTWFQHRRMLTPAFHYDILKPYVG
LMADSVRVMLDKWEELVSLDSHLEVLGHVSLMTLETIMKCAFSHQGSIQTDRNIQSYI
QAIRDLGNLTFSRIRNAFHQNDFIYRLTPEGRWSHRACQLAHQHTDAVIKLRKAHLQK
EGELEKVRSKRHLDFLDILLFARMENGSSLSDVDLRAEVDTFMFEGHDTTASGISWIL
YALASHPEHQQRCREEIQSLLRDGASITWDHLDKMPYTTMCIKEALRLYPPVPVISRD
MSKPITFPDGRSLPAGIPLSLSFYGLHHNPKVWPNPEVFDPSRFAPGSDRHSHAFLPF
SGGSRNCIGKQFAMNEMKVAVALTLLRFELAPDPSRVPVPIPRVVLKSKNGIHLQLRK
LL

CYP4A36    Canis familiaris (dog)
           UCSC Genome browser June 13, 2005
           This gene has a sequence gap that includes exons 5-9
           75% to CYP4A11 human, 73% to CYP4A22 human
16550556-16550750 exon 1
16553600-16553740 exon 2
16554459-16554503 exon 3
16554973-16555101 exon 4
16574267-16574332 exon 10
16574473-16574550 exon 11
16577168-16577332 exon 12 
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKTAQLYQRRQWMLKAIQQFPSPPSHWFFGHKQE
FQTGLELQELKKRTEKYRCASPLWLWGSRVSLIVYDPDYMKMIPGRS
DPKSEGAYRFMAPWI
GYGLLLLNGEIWFQHRRMLTPAFHYDILKPYVRLMVDSVQVML
DKWEELLSQNSHLEIFEHVSLMTLDTIMKCAFRYQGNH*ADR
NFQSYIQAIKDLNYLVFSRMRNVFYQKDIFYWLTSEGRRNHKACQLAHEHT
DRVIKLRKAQLQDEGELEK
VRNKRHLDFLDISFFAK
MENGRGLSDKDLRAEVDTFKFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASIT*
EHLDQMPYTTMCIKEALRLYLPVPTVGRELSKPITFPDGRSLPR
GFLVLLSFYALHHNSNVWPNPE
VFDPSRFAPDASRHSHAFLPFSGGSR
NCIGQHFAMKEMKVAVALTLLRFELAPDPFRIPVPTPKIVLMSKNGIHLHLRKLL*

CYP4A36-de10b11b12b    Canis familiaris (dog, boxer)
           UCSC Genome browser June 13, 2005
           Chromosome 15 adjacent to CYP4X1
16531225-16531290 exon 10 
16531430-16531507 exon 11 
16533933-16534070 exon 12
GFLVLLSFYALHHNPNVWPNPE
VFDPSHFAPDASRHSHAVLPFSGGAR
XXXXXXXXXNELKVAVALTLLRFELAPDPFRIPVSTPKIVLMSKNGIHLHLRKLL*

CYP4A37    Canis familiaris (dog, boxer)
           UCSC Genome browser June 13, 2005
           chr15 16582305-16601179
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQHRQWLLKAVQQFPSPPSHWFFGHKQE (0)
FQTGQELQVFQKWTEKYPCACPRWLWGSRVSLVVYDPDYMKMILGRS (1)
DPKAGGSYTFITPWI (1)
GYGLLLLHGEAWFQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDMNNLVFARVRNVFYQKDIFYGLTSEGRRNHKARQIAHQHT (1)
DRVIKLRKAQLQDEGELEKVRNKRHLDFLDILLFAK (0)
MENGKGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPK (1)
GFLVSLSFYALHHNPNVWPNPE (0)
VFDPSRFAPDASRHSHAFLPFSGGSR (2)
NCIGKHFAMNELKVAVALTLLRFELAPDPFKIPVPTPRIVLMSKNGIHLHLRKLL

CYP4A37    Canis familiaris (dog, beagle)
           No accession number
           Richard Graham
           submitted to nomenclature committee 6/9/05 
           mRNA 99% identical to boxer 4aa diffs
           clone name: group 1

CYP4A38    Canis familiaris (dog, boxer)
           UCSC Genome browser June 13, 2005
           Chromosome 15
16616983-16617177 exon 1 
16620038-16620178 exon 2 
16627267-16627311 exon 3 
16627767-16627895 exon 4 
16629076-16629201 exon 5 
16629573-16629725 exon 6 
16630161-16630268 exon 7 
16630360-16630551 exon 8 
16630646-16630777 exon 9 
16632476-16632541 exon 10
16632700-16632759 exon 11 frameshift extra "A" base
16634726-16634891 exon 12
MSVSLLSLTRPLDTVSGFLQVASLLGLALLLLKAAQFYWHRQWLLKAIQQFPSPPSHWFFGHRQE (0)
FQKGRELQELKKRTEKYPCASPRWLWGSRVSLVVYDPDYMRMILGRS (1)
DPKSDGSYRLMAPWI (1)
GYGLLLLNGEIWFQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDLNNLVFARVRNVFYQKDIFYGLTSEGRRNHKACQLAHEHT (1)
DRVIKLRKAQLQDEGELEKIRNKRHLDFLDILLFAK (0)
MENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPR (1)
GFLVLLSFYALHHNPNVWPNPE (0)
VFDPSRFAPDASRHSHAFLPFSGGSR (2)
NCIGQHFAMNELKVAVALTLLRFELAPDPFRIPVPTPRIVLMSKNGIHLHLRKLL*

CYP4A38    Canis familiaris (dog, beagle)
           No accession number
           Richard Graham
           submitted to nomenclature committee 6/9/05 
           mRNA 100% identical to boxer except for frameshift
           clone name: group 2

CYP4A38    Canis familiaris (dog, beagle)
           No accession number
           Richard Graham
           submitted to nomenclature committee 6/9/05 
           mRNA 99% identical to boxer, 4 aa diffs
           clone name: group 3

CYP4A39    Canis familiaris (dog, boxer)
           UCSC Genome browser June 13, 2005
           Chr 15 16641912-16651675 
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQRRQWLLKAVQQFPSPPSHWLFGHKRE (0)
LQKGDELQLLLKWIEDFPCAFSRWIWGTEAEIMIYDPDYMKLILGRS (1)
DPKPDGSYKLMAPWI (1)
GYGLLLLNGETWSQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLSQNSHLEIFDHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDLNNLVFARMRNVFYQKDIFYGLTSEGRRNHKACQLAHQHT (1)
DRVIKLRKAQLQDKGELEKVRNKRHLDFLDILLFAK (0)
VENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPNVGRELSKPITFSDGRSLPK (1)
GFLVLLSFYALHHNPNVWPNPE (0)
VFDPSRFAPGVSRHSHAFLPFSGGSR (2)
NCIGQHFAMNEMKVAVALTLLRFELAPDPFRIPVPTPKIVLMSKNGIHLHLRKLL*

CYP4A39-de12b    Canis familiaris (dog, boxer)
           UCSC Genome browser June 13, 2005
           Chromosome 15
16655566-16655718 exon 12 (-) strand)
NCIGQQFAMNEMKVVTALCLLRFEFALDPLQLPVKMPQLILRSKNGIHLHL

CYP4A39-de9b     Canis familiaris (dog, boxer)
           UCSC Genome browser June 13, 2005
           Chromosome 15
16657179-16657292 exon 9
XXXXXMTYLTMCIKESFRLYPPVPQVYRQLSKPVNFVDGRSLPX

CYP4A40     Bos taurus (cow)
            See cattle page for details
MSVSALSPSRALGGVSGLLQVVSLLGLVLLLIKAAQLYLRRQWLLKALHHFPSPPSHWFCGHKWE
FQEEGELPHLLKRVEKYPRACVRWMWGTRALLLVYDPDYMKMVLGRS
DPKAQIIHRFVKPWI
GTGLLLLEGQTWFQHRRMLTPAFHYDILKPYVGIMADSVRVML
DKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSQQGSVQTDR 369
SSQSYIQAIKDVSHLIISRLRNAFHQNDLIYRLTPEGHWNHRACQLAHQHT 895
DAVIKERKVRLQKEGELEKVRSRRHLDFLDILLFAR 1445
MENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQS 1690
LLADGASITW 
DHLDQMPYTTMCIKEAMRLYPPVPVISRELSKPITFPDGHSLPA 1952
GILVSLSIYGLHHNPKVWPNPE
VFDPTRFAPGSTRHSHAFLPFSGGSR 3927
NCIGKQFAMNELKVAVALTLLRFELSPDSSRVPVPMPVIVLRSKNGIHLQLRKLSDPGGDK 

CYP4A41     Bos taurus (cow)
            See cattle page for details
MSVSVLSPTRALGGVSGLLQVVSLLGLVLLLLKAAQLYLRRQWLLKALHQFPSPPSHWFYGHKKE
FQKESELPPLLERVEKYPKACVRWLWGTKALVLVYDPDYMKVFLGRS
DPKPHRTYKYLAPWI
GTGLLLLEGQKWFQHRRMLTPAFRYDILKAYVGIMADSVRVML
DKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSHQGSVQMDR
SSQSYIQAIRDLSHLIVSRLRNAFHQNDLIYRLTPEGRWNHRACQLTHQHT
DAVIKERKAHLQKEGELEKVRSRRHLDFLDILLLAR
MENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITW
DHLDQMRYTTMCIKEAMRL
YPPVPFIGRELRKPITFPDGRSLPA
GILVSLSFYGLHHNPNVWPNPE
VFDPTRFSPGSTQHSYAFLPFSGGSR
NCIGKQFAMNELKVAVALTLLRFELSPDPSRVPVPTPIMVLRSKNGIHLQLRKLSDPGGDKDKL

CYP4A42P    Bos taurus (cow)
            See cattle page for details
KEKELEELLKRVEEFPYAYPCWMWG
DNVHLVVYDPDYMKVVLRRS
NPKSEDIYRFLAPWI
GLLLLEEQTWFQHRQMLTPAFHYDILKPYLGLMADSVQGML
DKWEELVSQDSHLEILGDISLMTLDTIMKCVFSH*GSIRNDR
XXXXXXXXXXXXXXXXXXXLRNVFYQNDLIYRLTPEGQWSY
XXXXXXXXX
TDAVIEERKTCLRKEGELEKVRSRRHLDFLDILLFSRV
NGSSLSDEDLRAEVDTFIFGGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITW

CYP4A43P    human = CYP4A-se2[1]
            GenEMBL NT_04852.13 - strand exon 1
            7994933 MSVSVLNPNRLPDGVSGLLQGASLLSLLLLLLKAAQP*LHR 7994811

CYP4A44P    human = CYP4A-se4[2]
            GenEMBL NT_04852.13 exon 2 - strand
            8003576 XXXDQELKQFQKWVDF*IYPKRDFCDPVLTCCGGRKVHFLLYDPDKMEVILGRS 8003424

CYP4A-se1[12] human = CYP4A26P
            AL731892.5 
            76% to 4A11 C-term upstream of 4A11
            TCIGKKFAMNEL 135092
            135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
            NT_04852.13 - strand
7968299 TCIGKKFAMNELKVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRVPNHCGDKDQL* 7968105

CYP4A-se2[1] human = CYP4A43P
            GenEMBL NT_04852.13 - strand exon 1
            7994933 MSVSVLNPNRLPDGVSGLLQGASLLSLLLLLLKAAQP*LHR 7994811

CYP4A-se3[12] human = CYP4A27P
            AL731892.5 
            67% to 4A11 C-term
           168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
            NT_04852.13 - strand exon 12
8001510 NCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRLPNTCEDKNQI* 8001322

CYP4A-se4[2] human  = CYP4A44P
            GenEMBL NT_04852.13 exon 2 - strand
            8003576 XXXDQELKQFQKWVDF*IYPKRDFCDPVLTCCGGRKVHFLLYDPDKMEVILGRS 8003424

CYP4A       rabbit
            PIR PQ0048 (25 amino acids)
            Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
            Purification and characterization of two forms of cytochrome
            P-450 with omega-hydroxylase activities toward
            prostaglandin A and fatty acids from rabbit liver
            microsomes.
            J. Biochem. 107, 280-286 (1990)
            This fragment has 2 differences with 4A7

4B Subfamily

CYP4B1      human
            GenEMBL NM_000779 J02871
            Nhamburo,P.T., Gonzalez,F.J., McBride,O.W., Gelboin,H.V. and
            Kimura,S.
            Identification of a new P450 expressed in human lung: Complete cDNA
            sequence, cDNA-directed expression and chromosome mapping
            Biochemistry 28, 8060-8066 (1989)

CYP4B1      human
            GenEMBL X16699
            Yokotani,N., Sogawa,K., Matsubara,S., Gotoh,O., Kusunose,E.,
            Kusunose,M. and Fujii-Kuriyama,Y.
            cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA
            library of human placenta. Gene structure and expression
            Eur. J. Biochem. 187 (1), 23-29 (1990)

CYP4B1      Pan troglodytes (chimp)
            XM_513140.3 5 aa diffs to CYP4B1 human
            Missing the N-term
GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVA                      VFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYL  AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDE  KVQKKIQNRRHLDFLDILLGAWDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY  CMALYPEHQHRCREEVREILGDQDSFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQL  SKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDPLRFSTENASKRHPFAFMP  FSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLCSKNGFHLHLK  
PLGPGSGK

CYP4B1      Macaca mulatta (rhesus monkey)
            NM_000779
            95% to human 4B1
MVPSFLSLRLSCLGLWASGLILVLGFLKLIRLLLRRQRLAKAMGNFPGPPTHWLFGHALE (0)
IQQTGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG (1)
DPKAPDVYDFFLQWI (1)
GRGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML (0)
DKWEEKAQEGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHR (2)
DSSYYLAVSDLTLLMQQRLVSFHYHNDFIYWLTPHGRRFLRACQVAHDHT (1)
DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR (0)
DEDDSKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDSFQW (2)
DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA (1)
GSLISMHIYALHRNSAVWPDPE (0)
VFDPLRFSTENASKRHPFAFMPFSAGPR (2)
NCIGQQFAMSEMKVVTAMCLLHFEFSLDPSRLPIKMLQLVLRSKNGIHLHLKPLGPGSGK

CYP4B1      rat 
            GenEMBL M29853
            Gasser,R. and Philpot,R.M.
            Primary structures of cytochrome P-450 isozyme 5 from rabbit and
            rat and regulation of species-dependent expression and induction in
            lung and liver: Identification of a new cytochrome P-450 gene
            subfamily IVB
            Mol. Pharmacol. 35, 617-625 (1989)

CYP4B1      rabbit 
            GenEMBL M29852
            Gasser,R. and Philpot,R.M.
            Primary structures of cytochrome P-450 isozyme 5 from rabbit and
            rat and regulation of species-dependent expression and induction in
            lung and liver: Identification of a new cytochrome P-450 gene
            subfamily IVB
            Mol. Pharmacol. 35, 617-625 (1989)

CYP4B1      rabbit
            GenEMBL AF176914
            Mastyugin,V., Aversa,E., Bonazzi,A., Vafaes,C., Mieyal,P. and
            Schwartzman,M.L.
            Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal
            epithelium: involvement of a cytochrome P-4504B1 isoform
            J. Pharmacol. Exp. Ther. 289 (3), 1611-1619 (1999)

CYP4B1      Canis familaris (dog)
            XM_845151.1 
            86% to CYP4B1 human
MVSTLLSLSVSHLVLWATGLILVLGFLKLIRLLLRRQMLARAMD
SFPGPPTHWLFGHAQEIQQTGSLDKVVTWAHQYDYAHPLWLGPFLGFLNIYEPDYAKA
VYSRGDPKAADVYDFFLQWIGKGLLVLQGPKWYQHRKLLTPGFHYDVLKSYVAVFTNS
THAMLDKWEEKAREDKSFDIFCDVGYMALDSLMKCTFGKGDSSLGHRDSSYYSAVRDL
TLLMQQRIESFQYHNDFIYWLTPHGRRFLRACQAAHDHTDQVIRERKAALQDEKEQEK
IQNRRHLDFLDILLGARDENGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY
PQHQHRCREEVCEILGDRDSFQWDDLVKMTYLTMCIKESFRLYPPVPQVYRQLSKPVN
FVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSSENVARRHPFAFMPFSAGP
RNCIGQQFAMNEMKVVTALCLLRFEFALDPLQLPVKMPQLILRSKNGIHLHLKSLRLG
SGK

Cyp4b1      mouse
            GenEMBL D50834 (1871bp)
            Imaoka,S., Hiroi,T., Tamura,Y., Yamazaki,H., Shimada,T., Komori,M.,
            Degawa,M. and Funae,Y.
            Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal
            cytochrome P450, CYP4B1: Cloning and characterization of mouse
            Cyp4b1.
            Arch. Biochem. Biophys. 321, 255-262 (1995)

Cyp4b1      mouse
            GenEMBL NT_039264.1 - strand
15793364 MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALE 15793185
15787670 IQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRG 15787524
15787339 DPKAAYVYDFFLQWIGK 15787289
15786110 GKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVML 15785982
15782099 DKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSH 15781943
15781704 SDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHT 15781552
15781416 DHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGAR 15781309
15774536 DESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQW 15774345
15772616 DDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPA 15772485
15771566 GSLISLHIYALHRNSAVWPDPE 15771501
15771405 VFDPLRFSPENMTGRHPFAFMPFSAGP 15771325
15770907 RNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKPLGPGSGK 15770725

Cyp4b1-de2b4b mouse
            GenEMBL NT_039264.1 - strand 
            v in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15690726 DLDKVGTWTEQFPYAHPLWLGQFVVFLNIYEPDYSKAVYSQA 15690601
15689190 GKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVML 15689062

Cyp4b1-de10c11c12c mouse
             GenEMBL NT_039264.1 - strand
             u in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15728822 GSLISLHIYALHRNSAVWPDPE 15728757
15728661 VFDPLRFSPENMTGRHPFAFMPFSAGP 15728581
15728149 RNCIGQQFAMNKMKVV 15728102
15728100 TALCLLCFEISQDPLKIPIKVPQLILGSKNGIHLYLKPLGPGSGK 15727966

CYP4B1      wallaby
            No accession number
            Ross McKinnon
            Submitted to nomenclature committee Dec. 2, 2002
            Clone name W4B2
            73% to mouse Cyp4b1

CYP4B1      Sus scrofa (pig)
            AK231936.1
            CJ022616.1 BP435822.1 CF179484.1 AW480803.1 CJ026219.1
            BP440482.1 
            80% to human 4B1, 81% to cow 4B2
MVPALLSLSLSHLSLWALGLILALGVLKLTSLLLRRQMLARAMDK
FPGPPTHWIFGHALEIQQTGSLDKMVSWAHQFPHAHPLWLGPFLGFLNIYEPEYAKAVYS
RGDPKASDLYDFFLQWIGKGLLVLHGPKWFQHRKLLTPGFHHDVLKPYVAVMANSARVML
DKWEEKAREDKSFDIYHDVGHMALELLMKC
TFGKGTSGLNYSDNAYHLAVRDLTLLMQQRLSSFQYHNDFIYWLTPHGRRFLRACRVAHD
HTDQVIRERKAALQDKEEQERIQSRRHLDFLDILLGAQDEDRVKLPDADLRAEVDTFMFG
GHDTTTRGISWFLYCMSLNPEHQHRCRDEIREILGDRDSIQGEDLGKMTYLTMCIRESFRLYPP
GPQVYRQLSEPVSFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRH
PFAFLPFSAGPRNCIGQQFAMNEMKVVAALSLLRFEFAPDPSRPPIPMPQLTLCSKTGIH
LRLTSLGQGSGK*

CYP4B1      Bos taurus cattle
            GenEMBL AW347853
            Differs from 4B2 shown below
            This seq is 100% match to pig 4B1 (possible contamination?)
            Efforts to extend this sequence in genomic DNA have failed
3 DGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRHPFAFLPFSAGPRNC 179

CYP4B2      Bos taurus (cow)
            See cattle page for details
            94% to goat 4B2 only 82% to human 4B1
            note: there was some evidence for two CYP4B genes in cow,
            but only one can be found in the genomic data so far.
            This may be the CYP4B1 ortholog and 4B1 may be a pig sequence.
MVPVLLSLSLSHLSLWAFALVSVLVFLKLTRLLLRRQMLARAMDRFSGPPTHWLFGHALE
IQQTGSLDKVVSWTHEFPYAHQLWVGQFLGFLNIYDPDYAKAVYSR
GDPKAPDFYDFFLQWI
GKGLLVLQGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML
DKWEKKAREQKSFDIYSDVGHMALDSLMKCTFGKGTSGLNDR
DNNYYLSVKELTLLMQQRIDSFQYHNDFIYFLTPHGRRFLRACQVAHDHT
DQVIRERKAALQDEKERERIQSKRHLDFLDILLGAW
DEEGIKLSDEDLRAEVDTFMFEGHDTTTSAISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKW
DDLAEMTYLTMCIKESFRL
YPPVPQVYRQLSQPVNFVDGRSLPE
GSLISLHIYALHRNSTVWPDPE
VFDPLRFSPENVAGRHSFAFIPFSAGPR
NCIGQQFAMAEVKVVTALCLLRFEFSPDPSRLPIKMPQLVLRSKNGIHLHLKPLGPGSEK*

CYP4B2      Capra hircus (goat)
            AY151046
            Garold Yost
            Submitted to nomenclature committee August 2002
            82% to human 4B1, 94% to bovine 4B2
MVPVLLSLSLSHLSLWAFGLVSVLVFLKLTRLLLRRQMLARAMD
RFSGPPTHWLFGHALEIQQTGGLDKVVYWTHQFPYAHQLWLGRFLGFLNIYDPEYAKA
VYSRGDPKAPDVYDFFLQWIGKGLLVLQGPKWFQHRKLLTPGFHYDVLKPYVAVFAES
ARVMLDKWEKKAREQKSFDIFSDVGHMALDSLMKCTFGKGTSGLNDRDNNYYLAVSEL
TLLMQQRIDSFQYHNDFIYFLTPHGRRFLRACQVAHDHTDQVIRERKAALQDKKEREK
IQSKRHLDFLDILLGARDEEGIKLSDEDLRAEVNTFMFAGHDTTTSAISWVLYCMSLY
PEHQRRCREEIQEILGDRDSLKWEDLAEMTYLTMCIKESFRLYPPVPQVYRQLSKPVN
FVDGRSLPAGSLISLHIYALHRNSTVWTDPEVFDPLRFSPENVAGRHSFAFIPFSAGP
RNCIGQQFAMNEVKVVTALCLLRFEFSPDPSKLPIQMPQLVLRSKNGIHLHLKPVGPG
SEK

CYP4B2      Bos taurus cattle
            GenEMBL BF602740
            94% to goat 4B2 only 82% to human 4B1
3   AISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKWDDLAEMTYLTMCIKESFRLYPPVPQ 182
183 VYRQLSQPVNFVDGRSLPEGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENVARRHSFA 362
363 FIPFSAGPRNCIGQQFAMAEVKVVTALCLLRFEFAPDP 476

CYP4B3      wallaby
            No accession number
            Ross McKinnon
            Submitted to nomenclature committee Dec. 2, 2002
            Clone name W4B1
            69% to mouse Cyp4b1

4C Subfamily

CYP4C1      Blaberus discoidalis (cockroach)
            GenEMBL M63798 Swiss P29981 (511 amino acids)
            Bradfield,J.Y., Lee,Y.-H. and Keeley,L.L.
            Cytochrome P450 family 4 in a cockroach: Molecular cloning and
            regulation by hypertrehalosemic hormone
            Proc. Natl. Acad. Sci. U.S.A. 88, 4558-4562 (1991)

CYP4C2      Anopheles albimanus (mosquito)
            GenEMBL L38678 (379bp) PIR PC2257 (126 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

Cyp4c3      Drosophila melanogaster
            GenEMBL U34323(379bp)
            Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
            ffrench-Constant,R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genet. 251, 290-297 (1996)

Cyp4c3      Drosophila melanogaster
            AC014779 73845-80196 also AC008219

Cyp4c3      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4C4      Diploptera punctata (Pacific beetle roach)
            GenEMBL AF071073
            Andersen,J.F. and Feyereisen,R.
            Cockroach fat body CYP4C4
            Unpublished

CYP4C5      Diploptera punctata (Pacific beetle roach)
            GenEMBL AF071074
            Andersen,J.F. and Feyereisen,R.
            Cockroach fat body CYP4C5
            Unpublished

CYP4C6      Diploptera punctata (Pacific beetle roach)
            GenEMBL AF071075
            Andersen,J.F. and Feyereisen,R.
            Cockroach fat body CYP4C6
            Unpublished

CYP4C7      Diploptera punctata (Pacific beetle roach)
            GenEMBL AF071072
            Andersen,J.F. and Feyereisen,R.
            CYP4C7, a P450 from cockroach corpora allata
            Unpublished

CYP4C8      Mastotermes darwiniensis (Australian termite)
            GenEMBL U77126(432bp)
            Falckh,P.H.J., Balcombe,W.M., Haritos,V.S. and Ahokas,J.T.
            Isolation, identification and sequence of a cytochrome P450 in an
            Australian termite, Mastotermes darwiniensis.
            unpublished (1996)
            note: 92 amino acid C-terminal fragment

CYP4C9      Coptotermes acinaciformis (termite)
            GenEMBL AF046008
            Patrick Falckh
            C4-8_9-A 

CYP4C10     Coptotermes acinaciformis (termite)
            GenEMBL AF046009
            Patrick Falckh
            C4-8_9-I 

CYP4C11     Mastotermes darwiniensis (Australian termite)
            GenEMBL AF067631
            Quoc Wu
            M4-150.4

CYP4C12     Mastotermes darwiniensis (Australian termite)
            GenEMBL AF067632
            Quoc Wu
            M4-100-8

CYP4C13     Mastotermes darwiniensis (Australian termite)
            GenEMBL AF067633
            Quoc Wu
            M4-240-2

CYP4C14     Coptotermes acinaciformis (termite)
            GenEMBL AF067634
            Quoc Wu
            4F-22_24

CYP4C15X    Orconectes limosus (crayfish)
            GenEMBL AF091117
            Chantal Dauphin-Villemant
            submitted to nomenclature committee
            this is a tentative assignment, this sequence may require its own  
            subfamily
            50% identical to 4C1 over full length, 58% identical over C-terminal
            renamed CYP4V11

CYP4C16X    Penaeus setiferus (shrimp)
            GenEMBL AF072854
            Mark Snyder
            submitted to nomenclature committee
            renamed CYP4V12

CYP4C17X    Haliotis rufescens (red abalone)
            GenEMBL AF072853
            Mark Snyder
            submitted to nomenclature committee
            renamed CYP4V13

CYP4C18X    Homarus americanus (lobster)
            GenEMBL AF072852
            Mark Snyder
            submitted to nomenclature committee
            renamed CYP4V14

CYP4C19     Lytechinus anamesis (sea urchin)
            GenEMBL AF072850
            Mark Snyder
            submitted to nomenclature committee
            first sequence from sea urchin

CYP4C20     Lytechinus anamesis (sea urchin)
            GenEMBL AF072851
            Mark Snyder
            submitted to nomenclature committee
            second sequence from sea urchin

CYP4C21     Blattella germanica (German cockroach)
            no accession number
            Jeff Scott
            submitted to nomenclature committee Dec. 30, 1998

CYP4C22v1   Culex pipiens pallens (mosquito)
            GenEMBL AF157093
            Zhu Changliang, Dept. of Parasitology, Nanjing University
            submitted to nomenclature committee 5/20/99
            PCR C-terminal fragment 150 amino acids
            clone name NYDR2 81% identical to 4C2 
            this sequence has one frameshift
EVDTFMFEGHDTTSAAISWILLLLGAEPAIQDRIVEEIDEIMGG
DRDRFPTMKELNDMKYLECCIKEGLRLYPSVPLIARKLVEDCVVQDYTIPAGTTAMIV
VYQLHRDPAVFPNPDKFNPDHFAPENCRGRHPYAYIPFMAGPRNCIGH

CYP4C22v2  Culex pipiens
           AF208659
           Changliang Zhu
           Clone NYDS6 PCR fragment 97% identical to 4C22v1
           Submitted to nomenclature committee 9/30/99
TSAAISWILLLLGAEPAIQDRIVEEIDQIMGGDRDRFPTMKELN
DMKYLECCIKEGLRLYPSVPLIARQLVEDCVVQDYSIPAGTTAMIVVYQPHRDPAVFP
NPDKFNPDHFAPENCRGRHPYAYI

CYP4C23    Culex pipiens pallens (mosquito)
           GenEMBL AF157090
           Zhu Changliang, Dept. of Parasitology, Nanjing University
           submitted to nomenclature committee 5/20/99
           PCR C-terminal fragment 167 amino acids
           clone name NYDS1 84% identical to AF117650 at C-terminal 44 amino acids 
           this sequence has numerous frameshifts and insertions/deletions it may
           be a pseudogene
MFEGHDTTAAGIILTIMLPANEQDAQRRVYEDLSKARRLKPEHE
AFTIADYTNLKYLDRFVKEALRLYPPVSFISRSLTGRLDVGRYSKLPVNQILVHIELL
NRSHHHLAARNYRQHSHLRSAPYPEQFPDPERFDPDRFLPEVSAKRNPYAYVPFCAGP
RNCIGH

CYP4C24X   Orconectes limosus (crayfish)
           no accession number
           C. Dauphin-Villemant, M. Tom, M. Waterman and D. Bšcking
           submited to nomenclature committee 6/15/99
           name changed to CYP4V21, 86% to CYP4V18

CYP4C25    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450Q 
           CYPb1x3 on chromosome 1
           91% identical to 4C2

CYP4C25     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPb1x3

CYP4C25     Anopheles funestus (mosquito)
            no accession number
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            submitted to nomenclature committee 11/17/04
            submitted name sequence 5
            98% identical to CYP4C25 Anopheles gambiae probable ortholog
            only 2 amino acid differences

CYP4C26    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450S
           CYPb1x1 on chromosome 1
           73% identical to 4C2

CYP4C26     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPb1x1

CYP4C27    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450I
           CYPo3r3 on chromosome 3
           58% identical to 4C6

CYP4C27     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPo3r3

CYP4C28    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450R
           CYPs3l1 on chromosome 3
           61% identical to 4C2

CYP4C28     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs3l1

CYP4C29X   Cherax quadricarinatus (crayfish)
           No accession number 
           Moshe Tom
           Submitted to nomenclature committee May 4, 2000
           Clusters with the other crayfish sequence 4C24 on trees
           Reanmed CYP4V15

CYP4C30    Coscinasterias muricata Australian sea star (11 armed starfish)
           No accession number
           Karl Herron
           Submitted to nomenclature committee Oct. 9, 2001
           63% to 4C19 partial seq. from I-helix to heme

CYP4C31    Daphnia pulex (Daphnia, water flea)
           No accession number
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.5 203 aa
           65% to 4C24 crayfish 65% to 4C16 shrimp 69% to 4C18 lobster 
           68% to 4C17 abalone 82% to 4C33

CYP4C32    Daphnia pulex (Daphnia, water flea)
           No accession number
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.6 149 aa
           95% to 4C34

CYP4C33    Daphnia pulex (Daphnia, water flea)
           No accession number
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.14 200 aa
           62% to 4C24 crayfish 61% to 4C16 shrimp 66% to 4C18 lobster 
           66% to 4C17 abalone 82% to 4C31

CYP4C34    Daphnia pulex (Daphnia, water flea)
           No accession number
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.16 206 aa
           61% to 4C24 crayfish 63% to 4C16 shrimp 64% to 4C18 lobster 
           65% to 4C17 abalone 95% to 4C32

CYP4C35     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPo3r1

CYP4C36     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPo3r2

CYP4C37     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPb1x2

CYP4C38    Aedes aegypti (yellow fever mosquito)

CYP4C38    Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T1.4

CYP4C38    Culex pipiens

CYP4C39X   Carcinus maenas (shore crab) 
           GenEMBL AY328467
           Kim Rewitz
           submitted to nomenclature committee 6/18/2003
           59.5% to 4C15
           renamed CYP4V16

CYP4C40    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 3 same as contig2
           88% to 4C36
           probable ortholog of 4C35
           note 4C35 is only 84% to 4C36 and less to all other gambiae CYP4Cs

CYP4C41    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 9 
           93% to 4C27
           probable ortholog of 4C27

CYP4C42     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4C 
            83% to 4C3 (106 aa)

CYP4C43v1   Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #2v1
            72% to 4C8 I-helix to heme, 99.5% identical to CYP4C43v2

CYP4C43v2   Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #2v2
            71% to 4C8 I-helix to heme, 99.5% identical to CYP4C43v1

CYP4C44v1   Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #3v1
            88% to 4C14 I-helix to heme, 99.5% identical to CYP4C44v2

CYP4C44v2   Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #3v2
            88% to 4C14 I-helix to heme, 99.5% identical to CYP4C44v1

CYP4C45v1   Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #4v1
            66% to 4C13 I-helix to heme, 99.7% identical to CYP4C45v2

CYP4C45v2   Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #4v2
            66% to 4C12 I-helix to heme, 99.7% identical to CYP4C45v1

CYP4C46     Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #5
            86% to 4C14 I-helix to heme

CYP4C47     Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #6
            61% to 4C13 I-helix to heme
            note name may change when full seq is known

CYP4C48     Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #7
            90% to 4C9 I-helix to heme

CYP4C49X    Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Mark Hahn,  Kristen Whalen
            Submitted to nomenclature committee Oct. 24, 2005
            Clone name 58_23_ext
            63% identical to CYP4C17 Haliotis rufescens (red abalone) partial seq.
            renamed CYP4V10, one aa difference to CYP4V10v1

CYP4C50    Aedes aegypti (yellow fever mosquito)

CYP4C50v1  Culex pipiens

CYP4C50v2  Culex pipiens

CYP4C51    Aedes aegypti (yellow fever mosquito)

CYP4C51v1  Culex pipiens

CYP4C51v2  Culex pipiens

CYP4C52    Aedes aegypti (yellow fever mosquito)

CYP4C52v1  Culex pipiens

CYP4C52v2  Culex pipiens

CYP4C53    Daphnia magna (water flea)
           GenEMBL AB257772
           Yoshinori Ikenaka
           Submitted to nomenclature committee 8/28/06
           CYP family-2, full length sequence
           70% to CYP4C31, amino acids 88 to end 55% to 4V2 human
           The CYP4C subfamily in invertebrates may be the orthologous
           group to the chordate CYP4V sequences

CYP4C53    Daphnia pulex (water flea)

CYP4C54X  Litopenaeus vannamei (Pacific white shrimp)
          No accession number
          Shirley Chan
          Submitted to nomenclature committee August 29, 2006
          58% to 4C39 shore crab, 64% to 4C32 Daphnia, 62% to 4C31 Daphnia, 
          49% to 4C25 Anopheles, 48% to 4C53 Daphnia, 47% to 4C3 Drosophila
          Clone name Lv03
          Renamed CYP4V17

CYP4C55    Daphnia pulex (water flea)

CYP4C56    Daphnia pulex (water flea)

CYP4C57    Daphnia pulex (water flea)

CYP4C58    Daphnia pulex (water flea)

CYP4C59    Daphnia pulex (water flea)

CYP4C60    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4C61    Nilaparvata lugens (Homoptera: Delphacidae) brown planthopper
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee 5/23/08
           Clone CYP4-2
           55% to CYP4C62, 47% to CYP4C27

CYP4C62    Nilaparvata lugens (Homoptera: Delphacidae) brown planthopper
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee 5/23/08
           Clone CYP4-6
           55% to CYP4C1

CYP4C62    Laodelphax striatellus (small brown planthopper)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee May, 15, 2011
           96% to CYP4C62 Nilaparvata lugens (brown planthopper)
           presumed ortholog, missing C-term

CYP4C62    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           96% to CYP4C62 Nilaparvata lugens (brown planthopper)
           presumed ortholog, complete seq. 2 aa diffs to Jia Shuangs seq.

CYP4C63v1  Trialeurodes vaporariorum (whitefly)

CYP4C63v2  Trialeurodes vaporariorum (whitefly)

CYP4C64    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           52% to CYP4CS1 Trialeurodes vaporariorum (whitefly)

CYP4C65    Sogatella frucifera (white-backed plant hopper)
           No accession number
           Shi Xiaoqin
           Submitted to nomenclature committee March 25, 2011
           Clone name sf52
           87% to CYP4C61 Nilaparvata lugens

CYP4C66    Sogatella frucifera (white-backed plant hopper)
           No accession number
           Shi Xiaoqin
           Submitted to nomenclature committee March 25, 2011
           Clone name sf46
           73% to CYP4C1 cockroach

CYP4C67    Diaphorina citri Kuwayama (Asian citrus psyllid)
           No accession number 
           Siddharth Tiwari
           Submitted to nomenclature committee April 7, 2011
           75% to CYP4C63v1 whitefly

CYP4C68    Diaphorina citri Kuwayama (Asian citrus psyllid)
           No accession number 
           Siddharth Tiwari
           Submitted to nomenclature committee April 7, 2011
           65% to CYP4C1 cockroach

CYP4C69    Locusta migratoria manilensis
           No accession number
           Xiaoyu Ren 
           Submitted to nomenclature committee Nov. 8, 2011
           54% to CYP4C62 Laodelphax striatellus

CYP4C70    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           63% to CYP4C62, incomplete

CYP4C71    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           55% to CYP4C62, 82% to CYP4C61 Nilaparvata lugens, complete

CYP4C72    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           70% to CYP4C52 Aedes aegypti, EXXR to heme

CYP4C73    Locusta migratoria manilensis
           No accession number
           Xiaoyu Ren 
           Submitted to nomenclature committee Sept. 13, 2012
           60% to CYP4C64 Bemisia tabaci, 58% to CYP4C1 cockroach
           55% to CYP4C69 Locusta migratoria

4D Subfamily

Cyp4d1      Drosophila melanogaster
            GenEMBL X67645 (1675bp) Swiss P33269 (511 amino acids)
            PIR S25707 (511 amino acids)
            Gandhi,R., Varak,E. and Goldberg,M.L. 
            Molecular analysis of a cytochrome P450 gene of family 4 on the
            Drosophia X chromosome.
            DNA Cell Biol. 11, 397-404 (1992)
            note: X67645 has a probable frameshifts at the C-terminal
            see Z98269 and AF016992 to AF017004 for correct end

Cyp4d1      Drosophila melanogaster
            GenEMBL AC017770 49988-51720
            Alternative splice AC017770 48817-51720

Cyp4d1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4d1_v1b  Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser
            (alt splice, exon 1)

Cyp4d2      Drosophila melanogaster
            GenEMBL Z23005 (1481bp) X75955 (1883bp) PIR S41192 (496 amino acids)
            Frolov,M.V. and Alatortsev,V.E.
            Cluster of cytochrome P450 genes on the X-chromosome of
            Drosophila melanogaster
            DNA Cell Biol. 13, 663-668 (1994)
            probable frameshift at C-terminal
            see Al009194 and AF017006 to AF017019 for correct end

Cyp4d2      Drosophila melanogaster
            GenEMBL AC017770 comp(32267-34028)

Cyp4d2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4D3v1    Musca domestica (house fly)
            Rene Feyereisen
            submitted to nomenclature committee

CYP4d3v2    Musca domestica (house fly)
            No accession number 
            Nannan Liu
            submitted to nomenclature committee 7/20/06
            68% to 4d1 D. pseudoobscura 
            3 aa diffs to 4D3v1

CYP4D4v1    Musca domestica (house fly)
            Rene Feyereisen
            submitted to nomenclature committee

CYP4d4v2    Musca domestica (house fly)
            No accession number 
            Nannan Liu
            submitted to nomenclature committee 7/20/06
            57% to 4d14 D melano., 
            100% to 4D4v2 (PCR fragment), 4 aa diffs to 4D4v1

CYP4D5      Anopheles albimanus (mosquito)
            GenEMBL L38679 (382bp) PIR PC2270 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4D6      Anopheles albimanus (mosquito)
            GenEMBL L38680 (446bp) PIR PC2271 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4D7      Anopheles albimanus (mosquito)
            GenEMBL L38681 (447bp) PIR PC2272 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

Cyp4d8      Drosophila melanogaster
            GenEMBL U34329(385bp)
            Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
            ffrench-Constant,R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genet. 251, 290-297 (1996)
            Dro-G453 (formerly called 4N3)

Cyp4d8      Drosophila melanogaster
            GenEMBL AC017388 comp(37292-39859) 
            also AC010557 AC010112 AC010113

Cyp4d8      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4D9      Musca domestica
            Rene Feyereisen
            no accession number
            6-full
            submitted to nomenclature committee

CYP4D10     Drosophila mettleri
            GenEMBL U91634
            Jim Fogleman
            full length sequence  288mt
            submitted to nomenclature committee (one of 109 sequences)

CYP4D11     Ceratitis capitata (Mediterranean fruit fly)
            Phil Danielson
            Submitted to nomenclature committee
            MD60 PCR of C-terminal

CYP4D12     Ceratitis capitata (Mediterranean fruit fly)
            Phil Danielson
            Submitted to nomenclature committee
            MD5 PCR of C-terminal

CYP4D13     Ceratitis capitata (Mediterranean fruit fly)
            Phil Danielson
            Submitted to nomenclature committee
            MD84 PCR of C-terminal

Cyp4d14     Drosophila melanogaster
            GenEMBL AL009194 comp(10685-12421)
            also submitted by Michael Goldberg
            55% identical to Cyp4d2

Cyp4d14     Drosophila melanogaster
            GenEMBL AC017770 35699-37438

Cyp4d14     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4D15     Anopheles gambiae
            no accession number
            Hilary Ranson
            Submitted to nomenclature committee 8/9/99
            clone name P450E
            77% identical to 4D6

CYP4D15     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPe2r3

CYP4D16    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450F
           84% identical to 4D6

CYP4D16     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPe2r5

CYP4D17    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450H
           79% identical to 4D5

CYP4D17     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPe2r4

CYP4D18v1  Culex pipiens
           GenEMBL AF190775
           Changliang Zhu
           Clone NYDS2 PCR fragment 95% identical to 4D18v2, 66% to 4D6
           Submitted to nomenclature committee 9/30/99
TTSAMSFILGILAKHPEVQKKAYDEVRNVFGDDPSKPATLAMLN
ELNYLDMVIKETLRLYPSVPMFGRKMLENHDIGKFWQRNAVLLVKLNAPKPLPYGTIF
PAGSNVIVMPYIMGRDPEYFDDPLEFRPERFAVETSAEKSNPYRYV

CYP4D18v2  Culex pipiens
           AF191728
           Changliang Zhu
           Clone NYDR16 PCR fragment 95% identical to 4D18v1
           Submitted to nomenclature committee 9/30/99
TTSAMSFLLGVLAKHPEVQKKAYDEVRNVFGDDPSKPATLAMLN
ELNYLDMVIKETLRLYPSVPIFGRKMLENHDIGKFWHRNAVLLVKLNAPKPLPDGTIF
PAGSNVIIMPYIMGRDPDYFDDPLEFRPERFAVETSAEKSNPYRYV

CYP4D19    Culex pipiens
           CPIJ009477

CYP4D19v1  Culex pipiens
           AF190786
           Changliang Zhu
           Clone NYDR11 PCR fragment 3 diffs with 4D19v2
           Submitted to nomenclature committee 9/30/99
TSGVSFTLYNLAKYPTIQQKVHDEIIAVLGTDPHKPVTMATLNE
LTYLEMVIKETLRLFPSVPIIGRKCVEEVTIEGKTVPAGTNIIIGIYYMGRDANYYDN
PLEFIPERFEGEKSVEKFNPYKYV

CYP4D19v2  Culex pipiens
           AF190789
           Changliang Zhu
           Clone NYDR14 PCR fragment 3 diffs with 4D19v1
           Submitted to nomenclature committee 9/30/99
TTSGVSFTLYNLAKYPAIQQKVHDEIIAVLGTDPHKPVTMATLN
ELTYLEMVIKETLRLFPSVPIIGRKCVEEVTIEGKTVPAGTNIITGIYYMGRDANYYD
NPLEFIPERFEGEKSVGKFNPYKYV

CYP4D19v3  Culex pipiens
           GenEMBL AF190777
           Changliang Zhu
           Clone NYDS4 PCR fragment 95% identical to 4D19v2, 54% to 4D5
           Submitted to nomenclature committee 9/30/99
TTSGVSFTLYNLAKYPTIQQKVHDEIIAVLGTDPHKPVTMATLN
ELTYLEMVIKETLRLFPSLPIIGRKCVEEVTIEGKTVPAGTNIIIGIYYMGRDANYYD
NPPELIPERFEGEKSVEKFNPYKYV

Cyp4d20    Drosophila melanogaster
           GenEMBL AC019509 comp(19731-21636)

Cyp4d20     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4d21    Drosophila melanogaster
           GenEMBL AC020004 55466-57280

CYP4D22    Anopheles gambiae (malaria mosquito)
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450O
           50% identical to 4H5, 4H7 
           note the 4H subfamily might really be considered two differernt 
           subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.  
           4H20 falls between these. Revised seq now groups with CYP4Ds
           formerly CYP4H20

CYP4D22     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPe2r6

CYP4D23    Aedes aegypti (yellow fever mosquito)

CYP4D23v1  Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T2.8

CYP4D23v2  Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T1.3

CYP4D23v3  Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T1.1

CYP4D24    Aedes aegypti (yellow fever mosquito)

CYP4D24    Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T2.6

CYP4D25    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 5 
           94% to 4D22
           probable ortholog of 4D22

CYP4D26    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 8 
           85% to 4D15, 78% to 4D27

CYP4D27    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 10 
           86% to 4D17 78% to contig 10 possible ortholog of 4D17
           79% to 4D16 and 80% to 4D15

CYP4D28     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D1 
            55% to 4D2 (276 aa)

CYP4D29v1   Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D2 
            56% to 4D2 (278 aa)

CYP4D29v2   Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee Dec. 18, 2007
            clone name Luce0103K16 
            57% identical to Drosoph. CYP4d2 only 5 aa diffs to 4D29v1 98%

CYP4D30     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D3 
            82% to 4D3 (150 aa)

CYP4D31     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D4 
            72% to 4D4 (149 aa)

CYP4D32     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D5 
            72% to 4D2 (149 aa)

CYP4D33     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D6 
            63% to 4D2 81% to 4D29 (149 aa)

CYP4D34     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4D7 
            61% to 4D20 81% to 4D33 (150 aa)

CYP4D35     Musca domestica (house fly)
            No accession number
            Nannan Liu
            50% identical to 4d8, 79% to 4D36
            clone #12
            submitted to nomenclature committee 4/10/06

CYP4D36     Musca domestica (house fly)
            No accession number
            Nannan Liu
            61% identical to 4d4 fragment, 79% to 4D35
            clone #12prime 
            Missing C-term after EXXR motif
            submitted to nomenclature committee 4/10/06

CYP4D37    Aedes aegypti (yellow fever mosquito)

CYP4D38    Aedes aegypti (yellow fever mosquito)

CYP4D39    Aedes aegypti (yellow fever mosquito)

CYP4D40    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/19/07
           sequence 2
           84% to 03, 67% to 4D24 Aedes
           96% (5 aa diffs out of 127) to CYP4D18v2 AF191728 Culex pipiens
           CYP40 and CYP41 may be paralogs of CYP4D18

CYP4D40    Culex pipiens

CYP4D41    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/19/07
           sequence 3
           60% to CYP4D16 Anoph. 66% to 4D24 Aedes
           96% (5 aa diffs out of 127) to CYP4D18v2 AF191728 Culex pipiens
           CYP40 and CYP41 may be paralogs of CYP4D18

CYP4D41    Culex pipiens

CYP4D42    Culex pipiens pallens
           CB074945.1
           NJS1618(2) 488bp, NJ008 in Genbank entry
           58% to CYP4H12v5, 77% to 4D22, 84% to 4D23
GRGNSIEVDTFMFEGHDTTTIAITFTLMLLAKHPDIQEKVYQEVTEIIGKDLNAPTTYRN
LQDMKYLELVIKESLRLYPPVPIIGRKFTEKTEIDGKVVPEDSNFNVGIILMHRDPTQFE
DPERFDPERFSPERTTELSSPYAYIPFSAGPRNCIGQNH

CYP4D42v1  Culex pipiens

CYP4D42v2  Culex pipiens

CYP4D43    Culex pipiens pallens
           CB074951.1
           NJS1618(4) 488bp, NJ008 in Genbank entry 
           57% to CYP4D42 70% to 4D16
GRGNSIEVDTFMFEGHDTTTSAISFLMYRLARHPEVQRKVYEEIVAVIGADRDRPVTLAM
LNELHYLELVVKETLRLYPSVPFYGRKILENCEIEGRTFPAGANVIIMPFFMGRDSEYFE
DPQKFRPERFAVGTSAEKTNPYRYIPFSAGPRNCIGQNH

CYP4D43    Culex pipiens

CYP4D44    Culex pipiens

CYP4D45P   Culex pipiens

CYP4D46    Bactrocera dorsalis (Oriental fruit fly) 
           GU292422 (not released yet 2/1/2010)
           Jiang Hongbo 
           submitted to nomenclature committee 1/28/2010
           55% to CYP4d8 Drosophila melanogaster

CYP4D47     Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            66% to Cyp4d1 Drosophila melanogaster

CYP4D48     Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            56% to CYP4D4v2 housefly

CYP4D or 4AR   Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4I1.3

CYP4D or 4AR   Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T1.6

4E Subfamily

Cyp4e1      Drosophila melanogaster
            GenEMBL AC020402 44580-46698
            CYP4E1 HAS INSERT AT C-TERM VSKDGYISTTLGLQPAEKKSRDAHNHK

Cyp4e2      Drosophila melanogaster
            no accession number 
            Amichot, M., Brun, A., Cuany, A., Helvig, C., Salaun, J. P., Durst, F.
            and Berge, J. B.
            Expression study of CYP genes in drosophila strains
            resistant or sensitive to insecticides. In: Cytochrome P450 
            Lechner M.C. ed. John Libbey Eurotext, Paris.pp. 689-692 (1994)
            (PCR fragment) 144 amino acid region 

Cyp4e1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4e2      Drosophila melanogaster
            GenEMBL X86076(1408bp)
            Amichot,M., Brun,A., Cuany,A., LeMouel,T. and Berge,J.
            Cloning and expression study of CYP4E2 a novel P450 gene in
            drosophila.
            unpublished (1995)

Cyp4e2      Drosophila melanogaster
            GenEMBL U56957(1458bp) U34332(373bp)
            Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
            ffrench-Constant,R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genet. 251, 290-297 (1996)

Cyp4e2      Drosophila melanogaster
            GenEMBL AC020402 41848-44099

Cyp4e2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4e3      Drosophila melanogaster
            GenEMBL U34330(370bp)
            Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B., 
            ffrench-Constant, R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genetics 251, 290-297 (1996)
            DroG4-2

Cyp4e3      Drosophila melanogaster
            GenEMBL AC020324 73117-75125

Cyp4e3      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4e4x     Drosophila melanogaster
            GenEMBL U34331(379bp)
            Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
            ffrench-Constant,R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genet. 251, 290-297 (1996)
            formerly called 4N4
            note: this sequence is pretty far out in the 4E subfamily 
            it has been reassigned as Cyp4ae1

CYP4E5      Drosophila mettleri
            GenEMBL U78486
            Phil Danielson
            Mt1

CYP4E6      Ceratitis capitata (Mediterranean fruit fly)
            Phil Danielson
            Submitted to nomenclature committee
            MD21 PCR of C-terminal

CYP4E7     Musca domestica (house fly)
           no accession number (530 amino acids)
           Claus Tittiger and Gary Blomquist
           submitted to nomenclature committee

CYP4E8      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4E 
            70% to 4E2 (150 aa)

CYP4E9      Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            61% to Cyp4e2 Drosophila melanogaster

4F Subfamily

CYP4F1      rat
            GenEMBL S53039 M94548 (1977bp) Swiss P33274 (524 amino acids)
            PIR S29723 (524 amino acids) 
            Chen,L. and Hardwick,J.P.
            Identification of a new P450 subfamily, CYP4F1, expressed
            in rat hepatic tumors.
            Arch. Biochem. Biophys. 300, 18-23 (1993)
            Note: rat 4F1 has an alternatively spliced 3 prime untranslated exon

CYP4F2      human
            GenEMBL U02388 (2368bp)
            Chen,L. and Hardwick,J.P. 
            The human liver CYP4F2 cDNA sequence and expression in
            baculovirus-infected cells.
            unpublished (1993)

CYP4F2      human
            GenEMBL D26480 (2227bp)
            Kikuta,Y., Kusunose,E., Kondo,T., Yamamoto,S., Kinoshita,H. and
            Kusunose,M.
            Cloning and expression of a novel form of leukotriene B4
            omega-hydroxylase from human liver
            FEBS Lett. 348, 70-74 (1994)

CYP4F2-ie2b human = CYP4F63P

CYP4F2-de12b human CYP4F36P
            NT_011281.4|Hs19_11438 
            chromosome 19 detritus exon 12 75% TO 4F11
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448

CYP4F2      Pan troglodytes (chimpanzee)
            XM_001172535.2
            98% to human 
MSQLSLSWLGLGPVAASPWPLLLLVGASWLLAHVLAWTYAFYDN                      CRRLRCFPQPPRRNWFWGHQGMIHSSEEGLLYAQSLACTFGDMGCWWVGPWQAIVRIF                      HPTYIKPVLFAPAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL                      KPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP                      SEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR                      TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA                      SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLH                      PPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENI                      KERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA                      
EGGLWLRVEPLS

CYP4F3      human
            GenEMBL D12620 (2073bp) D12621 (1185bp) S63604 (2073bp)
            Swiss Q08477 (520 amino acids)
            Kikuta,Y., Kusunose,E., Endo,K., Yamamoto,S., Sogawa,K,
            Fujii-Kuriyama,Y. and Kusunose,M.
            A novel form of cytochrome P-450 family 4 in human
            polymorphonuclear leukocytes. cDNA cloning and expression of
            leukotriene B4 omega-hydroxylase.
            J. Biol. Chem. 268, 9376-9380 (1993)
            Note: three overlapping clones F-22, A-4 and M-6 are identical.
            Clone S-8 is different at 4 nucleotides and one amino acid.

CYP4F3      human
            GenEMBL AD000685 12 exons from 26660-44629

CYP4F3-ie2b human = CYP4F64P

CYP4F3      Pan troglodytes (chimp)
            7 aa diffs to CYP4F3 human
            UCSC genome browser chr19:15933453-15951437 (+) strand
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCRRLRCFPQPLKRNWFLGHLGL
IHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAP
AAIVPKDKVFYSFLKPWL
GDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMH
AKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQE
KPSEYIAAILELSALVTKRHQQILLYIDFLYYLTHDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVDDFLQAKAKSKTLDFIDVLLLSK
DEDGKKLSDEDIRAEADTFMFE
GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW
DDLAHLPFLTMCMKESLRLHPPVPAVSRCCTQDIVLPDGRVIPK
GIICLISVFGTHHNPAVWPDPE
VYDPFRFDPKNIKERSPLAFIPFSAGPR
NCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE

CYP4F3v2    human
            GenEMBL AF054821
            Kanga Morgan
            alternative splice variant of 4F3 with a cryptic exon at amino acids 
            67-114 this exon resembles the region in 4F2.

CYP4F3v2    Macaca fasicularis (cynomolgus monkey)
            DQ074799
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP4F2#2
            88% to 4F3v1, 94% to AF054821
            one exon may be alternate splice this is the case in humans
MPQLSLSSLGLGPVAVSPWLLLLLIGVSWLLARVLAWTYTFYDN
CRRLRCFPQPPKRNWFWGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIIPVIRFC
HPNLIRSVINASAAIVPKDKLFYSFLKPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL
KPYMKIFNESVNIMHAKWQLRASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
SEYIAAILELSALVAKRHQQFFLYIDFLYYLTHDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVEDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA
SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFVTMCIKESLRLH
PPVPAISRCCTQDIVLPDGRVIPKGVICHISVLGTHHNPAVWPDPEVYDPFRFDPENI
KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA
EGGLWLRVEPLS

CYP4F4      rat
            GenEMBL U39206
            Kawashima, H. and Strobel, H.W. (1995)
            BBRC 217, 1137-1144

CYP4F5      rat
            GenEMBL U39207
            Kawashima, H. and Strobel, H.W. (1995)
            BBRC 217, 1137-1144

CYP4F6      rat
            GenEMBL U39208
            Kawashima, H. and Strobel, H.W. (1995)
            BBRC 217, 1137-1144

CYP4F7      Dicentrarchus labrax (European sea bass)
            GenEMBL AF045925
            Sabourault C, Amichot M, Pauron D, Berge JB, Lafaurie M, Girard JP
            Cloning of CYP4F7, a kidney-specific P450 in the sea bass Dicentrarchus  
            labrax.
            Biochem Biophys Res Commun 258, 155-61 1999
            62% identical to human 4F3
            authors name CYP4Dl2

Query:     1 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKES 60
             GHDTTAS + W LY+LA+H +YQE+CRQEV EL++ R+  EIEW+DL+ LPF TMCI+ES
Sbjct:     1 GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES 180

Query:    61 LRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPK 120
             LRLH PV AV+R  TQD+ LP    +PKG ICL+S++GTHHNP VW +P  + P RFDP 
Sbjct:   181 LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT 360

Query:   121 NIKERSPLAFIPFSAGPRNCIGQAFAMAE 149
             N +  +  AFIPFS+GPRNCIGQ FA+AE
Sbjct:   361 NKEGLAAHAFIPFSSGPRNCIGQKFALAE 447

Sequence of reported protein may have 2 frameshifts at the end 
See alignment below to human 4F3 as query

Possible corrected sequence

GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES
LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT
NKEGLAAHAFIPFSSGPRNCIGQKFALAELRVVVALTLLRFRLTLGVNPEVGPSSGEVRR
LPQLVLRAEGGMWLQVEPL

 Score = 85 (29.9 bits), Expect = 6.3e-62, Sum P(2) = 6.3e-62
 Identities = 23/59 (38%), Positives = 31/59 (52%), Frame = +2

Query:   132 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVL--------PDHTEPRRKPELVLRAEG 182
             PF   P   + ++     ++VV+ LTLL FR+         P   E RR P+LVLRAEG
Sbjct:   395 PFPQAPGTALVRSSPWQRLRVVVALTLLRFRLTLGVNPEVGPSSGEVRRLPQLVLRAEG 571

 Score = 54 (19.0 bits), Expect = 1.2e-58, Sum P(2) = 1.2e-58
 Identities = 10/18 (55%), Positives = 12/18 (66%), Frame = +3

Query:   174 PELVLRAEGGLWLRVEPL 191
             P L     GG+WL+VEPL
Sbjct:   546 PSLSCVQRGGMWLQVEPL 599

CYP4F8      human
            GenEMBL AD000685 13 exons from 862-14599
            GenEMBL AF133298
            Bylund, J., Finnstršm, N. and Oliw, E. H. (1999) Gene Expression of a 
            Novel Cytochrome P450 of the CYP4F subfamily in Human Seminal Vesicles. 
            Biochem. Biophys. Res. Commun. 261, 169-174.
            submitted to nomenclature committee 10/30/98
            81.2% identity with CYP4F2 and 76.7% with CYP4F3.
            EST AI401776, AI349730

CYP4F8      Pan troglodytes (chimpanzee)
            XM_001172317.2
            98% to human 
MSLLSLSWLGLRPVAASPWLLLLVVGASWLLAHILAWTYAFYHN                      CRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLC                      HPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNIL                      KPYIKIFSKSANIMHAKWQHLAMEGSTCLDVFEHISLMTLDSLQKCIFSFESNCQEKP                      SEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDTVIQERRR                      TLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTA                      SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLH                      PPIPIFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENA                      QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRA                      
EDGLWLRVEPLG

CYP4F9P     HUMAN
            GenEMBL AC004609 complement(13903-33104 region)
            pseudogene N-terminal not on this cosmid, may be on adjacent cosmid
            missing 71 amino acids at N-terminal
            69% identical to 4F3 67% identical to 4F8
EGMRVLTQLVATYPQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKD
EAFYKFLKPWLGDGLLVNASDKWSCHRQMLMPAFHFNMLKPYMKFFTDSV
NIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQKCVFSFDSHCQEKPSQYIATI
LELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVHDFTEAIIQEQRH
TLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXXXXXX
GHNTTASGLSWVLYYLARHPEYQEHCWQEVQKLLKDHEPKEIEX
DDLAQLPFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLF
SNFETHHNPTVWLDPEVYDPFRFDPENSKERSPLAFIPFSAGSX
NCIGQAFAMAEMKVVLALTLLCFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS

CYP4F10P   human
           GenEMBL AD000685 exons 3-6 (cosmid ends in middle of exon 6) 
           49350 to end of cosmid.  Cannot recognize exons 1 and 2 after 4F3 gene 
           ends at 44623 and before exon 3 starts at 49350.  May be a pseudogene 
           (No ESTs)
SATIAPKDKVFYSFLKPWLG
DGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNIMH
AKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQE
KPSEYIASVLELSSLVAKRNQQ

CYP4F11    human
           GenEMBL AC005336 cosmid F20129 end of cosmid
           ESTs T56269 and T56204 opposite ends of clone yb89b03
           ESTs T69576 and T69645 opposite ends of clone yc44c03
           EST AA991369 and EST W23003
           N-terminal up though C helix and C-terminal from I helix to end is 
           Present middle region is not present.  The rest of this gene should be 
           on cosmid R28342 this is not in the database yet. About 22 amino acids 
           missing at N-terminal
N-terminal is on AC011517 rest is on AC020950
MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQC
FPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLI
LCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRML
TPAFHFNLKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDS
LQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQR
FRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD
EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEV
QELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG
RVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGP
RNCIGQAFAMAEMKVVLALTLLHFRILPTHIEPRRKPELILRAEGGLWLRVEPLGANSQ

CYP4F11    Pan troglodytes (chimpanzee)
           XM_003339308
           98% to human 
MPQLCLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYTFYDN                      CRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILC                      HPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNIL                      KPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP                      SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRR                      TLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTA                      SGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLH                      PPVPVISRCCTQDIVLPDGRVIPKGIVCLINIIGLHYNPTVWPDPEVYDPFRFDQENI                      KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRA                      
EGGLWLRVEPLGANSQ

CYP4F11     Macaca fasicularis (cynomolgus monkey)
            DQ074800
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP4F11_2-E5
            91% to 4F11 human 80% to 4F12 human
MLQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDN
CRHLQCFPQPPKQNWFWGHQGLVTPTEEGMKKVTQLVATYPQGFKFWMGPTFPLLTLC
HPDTIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNIL
KPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHLSLMTLDSVQKCVFNFESNCQEKP
SEYIAAILELSALIEKRNQHILVYPDFLYHLTPDGQRFRRACRLVHDFTDAVIQERRQ
TLRTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFGGHDTTA
SGLSWVLYHLAQHPEYQERCRQEARELLKDCEPVEIEWDDLAQLPFLTMCIKESLRLH
PPVPAVSRCCTQDIVLPDGRIIPKGIICIISIFGIHHNPTVWPDPEVYDPFRFYQENI
KERSPLAFIPFSAGPRNCIGQVFAMAEMKVVLALTLLRFRILPTHPEPCRKPELVLRT
EGGLWLRVEPLGVNSQ

CYP4F12    human
           GenEMBL AC004523  missing N-terminal
           UNIGENE entry Hs.110130 (12 ESTs)
           UNIGENE Hs.168862 R08175 and R08229 (opposite end)
           Complete cDNA sequence submitted by Johan Bylund June 16, 2000
mRNA for cytochrome P450, complete cds. AB035130
MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNN
CRRLQCFPQPPKRNWFWGHLGL
ITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLC
HPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNIL
KSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP
SEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR
TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTA
SGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENS
KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRA
EGGLWLRVEPLNVGLQ

CYP4F12    Pan troglodytes (chimp)
           XM_524141.3 96% to CYP4F12
MSLLSLPWLGLRQVAISPWLLLLLVVGSWLLTRILAWTYAFYNN              CRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMSATYSQGFTIWLGPIIPFIVL
CHPDTIRSITNASAAIALKDDLSIRFLKPWLGDGLLLSGVDKWSRHRRMLTPAFHFN
ILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQ
ERPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIR
ERRRTLPTQGIDDFLKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGG
HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVK
ESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCVINIIGVHHNPTVWPDPEVYDPF
RFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRR
KPELIMRAEGGLWLRVEHLNVGLQ

CYP4F12     Macaca fasicularis (cynomolgus monkey)
            DQ074801
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP4F12_2-G6
            91% to 4F12 human 82% to 4F11 human
MSLLSLPWLGLGPVATSPGLLLMLVVGSWLLARVLAWTYASYDN
RRRLQCFPQPPKQNWFWGHLGLITPTEEGLKNLTQISATYSQGFMIWMGPIIPFIVLC
HPDTIRSITNASAAIAPKDALSIRFLKPWLGEGILLSGGDKWSHHRRMLTPAFHFNIL
KPYIKIFNKSATIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSRCQERP
SEYIATILELSALVEKRSQHILQYMDFLYYLTQDGRRFRRACRLVHDFTDAVIQERRR
TLPTQGIDDFLKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFAGHDTTA
SGLSWILYNLVRHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRHCTQDIVLPDGRVIPKGIICVINITGVHHNPTVWPDPEVYDPYRFDPENS
KERSPLAFIPFSAGPRNCIGQAFAMAEMETVLALMLLHFRFLPDHTEPRRKPELILRA
EGGLWLRVEPLSAGLQ

Cyp4f13    mouse
           GenEMBL ESTs AI304244 ui64h08.y1, AA277579 va77c04.r1
           AA238458 my34d11.r1, AA277631 va81d08.r1
           AI265156 uj03h07.y1, AI120320 ub69c04.r1
           AI327511 mb31b06.y1, AA245188 mx09e08.r1
           AA799238 vx69h12.r1, AA797204 vw22d08.r1
           AI196488 ui64h08.x1, AI196852 ui67e09.x1
           AA511038 vh55g04.r1,AI323999 mb31b06.x1
           W64560   md70f05.r1, AI121221 ud70e01.x1
           Unigene Mm.22045 
           89% identical to rat CYP4F6 probable ortholog
CONSENSUS
MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWF
WGHLALMKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKP 
WLGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLD 
MFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQP 
FLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLD 
FIDVLLMAEDEHGKGLSNEDIRAEADTFMFGGHDTTTSALSWILYNXXXXXXXXXXXXX 
EVQELLRDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAI
PKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFA
MSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ* 

Cyp4f13    mouse
           GenEMBL NT_039649.1|Mm17_39689_30 - strand. 
           seq gap at exon 7,8
           Mm.22045 15 ESTs follow AI323999 BF533850 BC003954 AF233643
9512124 MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWFWGHLAL 9511927
9506326 MKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQA 9506186
9497701 SAAVAPKEMTLYGFLKPWL 9497645
9497556 GDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMH 9497428
9495574 AKWQCLASKGTSRLDMFEHISLMTLDSLQKCIFSVDSNCQE 9495452
9495033 SDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFT
        DAVIKERRSTLNTQGVEFLKAKAKTKTLDFI 9494788
        DVLLMAE
        DEHGKGLSNEDIRAEADTFMFGG
        HDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEW
9490318 DDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAIPK 9490187
9490098 GNICVISIFGVHHNPSVWPDPE 9490033
9489902 VYNPFRFDPENPQKRSPLAFIPFSAGT 9489822
9489452 RNCIGQTFAMSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ* 9489273

Cyp4f14    mouse
           GenEMBL ESTs 
AI098768 ue38c01.y1 
AI047403 ud65h03.y1 
AI099192 ue40b11.y1
AA237519 mx10h12.r1 
AA793220 vl85g08.r1 
AA869706 vq44d03.r1
AI118365 ue40b11.x1 chimeric clone contains a-L-Fucosidase
AA880205 vx39b01.r1 

consensus N-terminal to 370
MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWL 
MGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALK 
DVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQR 
VISDGSAPLDMFEHVSLMTLDSLQKCVVFSFDSNCQEKSSEYIAAILELSALVAK 
KDQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLD 
FIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQE 
VQELLRGREPEE 

gap of 69 amino acids

Cyp4f14 Cterminal 439-524
AI046446 ud65h03.x1 C-term 
AA274495 vb07d01.r1 C-term
AI121221 ud70e01.x1 C-term
consensus
VYDXFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVE
PLSAGAH*

UNIGENE entry Mm.10976 (C-terminal part only)
92% identical to rat CYP4F1 probable ortholog

Cyp4f14    mouse
           GenEMBL NT_039649.1|Mm17_39689_30 - strand 
           80% to 4f15 
           Mm.10976 C-term only. AF233644 AK018676 AC073720 91k-108k 
9480783 MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGM 9480586
9478580 VTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNA 9478440
9475637 SAAVALKDVIFYSILKPWL 9475581
9475492 GDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMH 9475364
9475203 AKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQE 9475081
9473316 KSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSK 9473047
9471961 DEDGKELSDEDIRAEADTFMFEG 9471893
9471699 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEW 9471571
9470493 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPK 9470362
9470279 GIICLISIFGIHHNPSVWPDPE 9470214
9470056 VYDPFRFDPENIKDSSPLAFIPFSAGP 9469976
9469605 RNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLSAGAH* 9469426



Cyp4f15     mouse
           GenEMBL ESTs
AI315840 uj47c01.y1
AI046615 ud70e01.y1 
AI048594 ud61g02.y1 this clone skips over exons
MPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWF
LGHLGMITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALK
EVVFYSFLKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQH
LALGGSARLDVFENISLMTLD

AI048594 ud61g02.y1 407-480
AI121221 ud70e01.x1 C-term this fragment also is an exact match to 4f13 and 4f14
There may have been gene conversion at the C-terminal of these three genes.
LLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPR 
NCIGQTFAMNEMXVXXXXXXXXXXXXPDDKEPRRKPELILRAEGGLWLRVEPLSTQ

No UNIGENE entry for these ESTs
92% identical to rat CYP4F4 probable ortholog

Cyp4f15    mouse
           GenEMBL NT_039649.1|Mm17_39689_30 + strand
           Mm.26539 AF233645 1EST AI121221 AK018904
MGFF
9250760 RMPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGM 9250960
9255347 ITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNA 9255487
9257115 SASVALKEVVFYSFLKPWL 9257171
9257260 GDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMH 9257388
9259977 AKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFDSNCQE 9260099
9262477 NPSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHSFTDAVIQDRRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSK 9262746
9264634 DEDGKELSDEDIRAEADTFMFEG 9264702
9264910 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIEW 9265038
9266608 DDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPK 9266739
9266828 GVICIINIFATHHNPTVWPDPE 9266893
9267035 VYDPFRFDPENIKDRSPLAFIPFSAGP 9267115
9267490 RNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ* 9267663

Cyp4f16  mouse
         GenEMBL ESTs AA059667 mj77a08.r1 
         AA863889 vx15d11.r1, AA673923 vo83a09.r1
         AA798644 vw34b12.r1, AA896484 vx63d12.r1
MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWF
SGHLGMIQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWL 
GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMF 
EHISLMTLDSLQKCLFGFDSNCQESPSEYISAILELSSXXXXXXXXXXXXXXX 

Cyp4f fragment a 93% identical to 4F5 88% to 4F6, 86% to 4F1 83% to 4F4
This fragment belongs to Cyp4f16
AA671839 vl02c09.r1
AA755081 vu02b08.r1 
LYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVL
LLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQRVQE
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHSPVIDXXXXXXX

Cyp4f fragment c 91% identical to 4F6, 86% to 4F1 and 4F5, 85% to 4F4
This fragment is part of Cyp4f16
AA688499 vq53e04.r1
AA791143 vv91d10.r1
AI036012 vz68a09.r1
AA794692 vu63c06.r1
DIVLXXXXXXPKGNICVISIFGIHHNPSVWPDPEXXX
PFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEM
KVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ*

92% identical to rat CYP4F5 probable ortholog

Cyp4f16    mouse
           GenEMBL NT_039649.1|Mm17_39689_30 + strand
           AF233646 AK009445 no UNIGENE entry ESTs AA059667 mj77a08.r1
9097626 MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWFSGHLGM 9097823
9100841 IQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQA 9100981
9103307 ALVAPKDMTFLRFLKPWL 9103360
9103446 GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH 9103574
9104679 AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE 9104801
9105455 SPSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR 9105622
9105623 ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK 9105724
9106943 DEHGKELSDEDIRAEADTFMFGG 9107011
9107206 HDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEW 9107334
9110828 DDLAQLPFLTMCIKESLRLHSPVIDLLRRCTRDIVLPDGRVIPK 9110959
9111076 GNICVISIFGIHHNPSVWPDPE 9111141
9111306 VYDPFRFDPENPQKRSPLAFIPFSAGP 9111386
9111628 RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ* 9111807

Cyp4f17   mouse
          GenEMBL ESTs AA387122 vc22e06.r1, AA386914 vc23b12.r1
          AA387149 vc22f06.r1
MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWF 
WGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQASAAVAPK 
EMIFYGFLKPWLGDGLLVSAGEKWSRH 
66% to CYP4F6 but 81% identical to a rat EST AI030199
The rat homolog to this gene has not been cloned yet.

Cyp4f17    mouse
           GenEMBL NT_039649.1|Mm17_39689_30 + strand
AC073754 (5 exon 9s) no UNIGENE entry 
9067942 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWFWGHMSM 9068139
9078921 VKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGPILQAS 9079064
9081387 AAVAPKEMIFYGFLKPWLG 9081443
9081530 DGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMH 9081655
9083143 AKWQRLTTKGTACLDMLEHISLMTLDSLQNCVFSFDSNCQE 9083265
9085028 SPSEYIAAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACDLVH 9085171
9085172 NFTDAVIRERRRTLSSQNLDEFLKSKTKSKTLDFIDVLLLAK 9085297
9085604 DEHGKELSDEDIRAEADTFMFG 9085669
9085859 GHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW 9085990
9088714 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPK 9088845
9088918 GTDCVISIFGVHHNPEVWPDPE 9088983
9089148 VYDPFRFDPENPQKRSPLAFIPFSAGPR 9089231
9089587 RNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRKPELILRAEGGLWLRVEPLSKGTQ* 9089766

Cyp4f17  rat 

Cyp4f18   frag.b      mouse
          GenEMBL ESTs AA716998 vu61b04.r1 AI006742 ua82h10.r1
frag. d AI006742 ua82h10.r1
PKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKXVVLA
frag. b AA716998 vu61b04.r1
LLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRD 
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVIS 
RISIFGTHHNPAVWPDPEV 
Cyp4f18 fragments b and d 90% identical to 4F6, 89% to 4F4, 88% to 4F5, 87% to 4F1
complete sequence known but confidential (Henry Strobel)

Cyp4f18    mouse
           GenEMBL NT_039466.1|Mm8_39506_30 - strand Chr 8
           Note: not in the 4f gene cluster on chr 19
           AF233647 AK007863 frag.b no UNIGENE entry EST AA716998 vu61b04.r1
138896 MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGL 138699
131761 IQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLA 131621
130374 PALVAPKDTVFYRFLKPWL 130318
130232 GDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMH 130104
127524 AKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQE 127402
125384 KPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDA
       VIRERRRTLLDQGGVDVLKAKAKAKTLDFIDVLLLSK 125115
122460 DEHGKALSDEDIRAEADTFMFG 122395
122191 GHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEW 122060
119223 DDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPK 119092
119002 GVISRISIFGTHHNPAVWPDPE 118937
118372 VYDPFRFDADNVKGRSPLAFIPFSAGP 118292
117969 RNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLKVEPLSAGAQ 117793

Cyp4f18  rat 

CYP4F19     rat
            GenEMBL AI030199 
            probable rat ortholog to 4f17 81% identical
            opposite end of this clone = BF554573 N-terminal
4f17     1 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPS 56
           MLQL LS LG GP    PWQLL +VG SL LARIL WI AFYDNYCRLRCFP+PPS
4f19     1 MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS 56

4f17 53 EPPSRHWFWGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQA 113
        +P SRHWFWGH+++VKNNEEGLQLL E SHQF D+HLCWIG FYPILRLIHPKFIG ILQA
4F19 53 QPLSRHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA 113
          * one amino acid difference in overlap

sequence = MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS
           RHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA

Cacgaggcattaacagagaagagcggaagtctctgggactcctgagaaaagg  (start met)
atgctacagctgagcctg tcctgcctgg gccgggggcc agtgactgtc tccccatggc agcttctgct
ggtggttggg acctccttgc ttctggctcg aattctgggc tggatcagtg ctttctatga
caactactgc cgtctccgct gcttccctca gcccccttca
CGG CAC TGG TTT TGG GGT CAC TTG AAC TTG GTC AAG AAC AAT GAA GAA GGC CTG CAG TTG TTG GCT GAA ATG AGC CAC CAG TTC CAG GAT ATC CAC CTC TGT TGG ATT GGG ATC TTC TAC CCC ATC CTG AGG CTT ATC CAC CCC AAG TTT ATT GGC CCC ATA CTC CAG GCC

CYP4F20X starfish
         Quoc Wu
         Given its own subfamily renamed CYP4FA1

CYP4F21  sheep
         AF246236
         Johan Bylund
         submitted to nomenclature committee 8/3/99
MLELSVSRLGFGLVAASPWLLLLVVGASWLLARVLAWTYTFYNN
CRLLQCFPQPPKQNWFFAHLYLVPPTEQGLRKSTQLAANYSHGYLIWFGPITPMIVFC
HPDMLRSIANASAAVAPKNMDFYKFLKPWLGDGLLLSAGDKWSRHRHLLTPTFHFNIL
KPYMKIFTKSTDIMHTKWERLITQGHTRLDMFEHLSLLTLDSLQKCVFSFDSNCQELS
SCRKPSKYITAILELSELVAKRNRQIFLHADFLYFLTLDGWRFLRACRLVHDFTDAVI
QERCRTLPENVDDFLKAKAKTKTLDFIDVLLLTKDEDGKRLSDEDIRAEADTFMFEGH
DTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRESKEIEWDNLAQLPFLTMCIKES
LRLHPPVTIISRCCTQDIVLPNGWVIPKGVICIIDIFGTHHNQSVWPDPEVYDPFRFD
QENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRFLPDKEEPRRKREL
ILRAEGGLWLQVEPLSASPQ

CYP4F22  human
         GenEMBL AC011492
assembled gene 13 exons 114537-140651 66% to 4F3, 65% to 4F11, 63% to 4F2,
59% to 4F8, 64% to 4F12, 57% to AC011537 exact intron boundaries need checking no ESTs
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMVS
PNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGAS
AAIAPKDDLFYGFLKPWLG
DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMH
AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQE
KMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRR
ALRQQGAEAWLKAKQGKTLDFIDVLLLAR
DEDGKELSDEDIRAEADTFMFEG
HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW
DDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPK
GIICLVSIYGTHHNPTVWPDSK
VYNPYRFDPDNPQQRSPLAYVPFSAGPR
NCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRPELILRTENGLWLKVEPLPPRA*

CYP4F22    Pan troglodytes (chimpanzee)
           XM_512456.3
           98% to human 
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLR                      LCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHNVLLVWMGP                      VLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLT                      PAFHFDILKPYMKIFNQCTDIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSH                      NSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT                      EVIQERRWALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMF                      EGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCI                      KESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPY                      RFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRR                      
KPELILRTENGLWLKVEPLPPRA

CYP4F22     Bos taurus (cow)
            See cattle page for details
MLPITEQLLHLLGLEKTAFRLYAVSGLLLTLLFFLFRLLLQFLRLCWGFYITCRRLRCFPQPPRRNWLLGHLGM (0)
YLPNERGLQDEKKVLDDMHHVILVWLGPVLPLVVLVHPDYIKPLVGAS (1)
AAVAPKDDLFYGFLKPWL (1)
GDGLLLSRGDKWSRHRRLLTPAFHFDILKPYMKIFNQCADTMH (0)
AKWRGLAEGSEVSLDMFEHVSLMTLDCLQKCVFSYNSNCQE (2)
KMSDYISAIIELSALVVRRQYRLHHYLDFIYYRTADGRRFRQACDTVHGFTTEVIQERRR ALRQQGAEAWFKAKQGKTLDFIDVLLLAK (0)
DEDGKELSDEDIRAEADTFMFE (1)
GHDTTSSGLSWVLFNLAKYPEYQEKCREEIQEVMKGRELEELEWSGQ (2)
DDLTQLPFTTMCIKESLRQFPPVTLVSRRCTEDIKLPDGRIIPK (1)
GIICLVSIYGTHYNPAVWPDSK (0)
VYNPYRFDPDNPQQRSPLAYVPFSAGPR (2)
NCIGQSFAMAEMRVAVALTLLRFRLFLDRTRKVRRKPELILRTENGIWLKVEPLPPRA*

CYP4F23P human
GenEMBL AC011492 
assembled gene 76% to 4F3, 76% to 4F8, 76% to 4F11, 73% to 4F2, 75% to 4F12, 
77% to 4F11, 60% to other 4F on this accession no ESTs also on AD000091
MSLLSLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYAFYDNCHRLQCFQQPPKRNCF*GHLSLVS
GNEEDMRLMEDLGHYFRDVQLWWLGSFYPVLHLVHPTFTAPVLQAS AAVALKDMSFYGFLKPWLG
DGLLISAGDKWRWHRHLLTPAFHFKILKPYVKIFNESTNIMH
AKWQRLALEGSVRLEMFEHISLMTLDSLQKCIFSFDSNCQE
KPSEYIDAILELSALSLKRHQHIFLLTDFLYFLTPNGRRFCRACDIVHNFTDAVIQERRR
TLTSQGVDDFLQAKAKSKTLDFIDVLLLAK DENGKKLSDENIRAEADTFMSG
GHDTTASGLSWVLYNLARYPEYQEHCRQEVQELLKNGDPKEIEW
DDLAQLPFLTMCLKESLRLHSPVSRIHRCCPQDGVLPDGRVIPK GNTCTISIFGIHHNPSVWPDPEV
YDPFRFDPENLQKTSPLAFIPFSAVPR
NCIGQTFAMAEMKVVLALTLLRFRVLPDHAEPRRKLELIVRAEDGLWLRVEPLSADLQ* 

CYP4F24P   human
GenEMBL AC011537.4 
77% to 4F11 missing last exon two in frame stops and a gap.
24346 MPQLSLSWLGLGQVAAFPWLLLLLAGASRLLAGFLAWTYAFYDNCRRLQYFPQPPKQKWF 24167
24166 WGQPGX 24152
6633 IIATEEGLKNLTQMSATYPQGFRIWLGPIFPFIVLCHPDIVRSITNAS 6788
8837 AAIAPKDDLSIRFLKPWLGEGILLSGGDK 9016
9017 WSRHRRMLTPAFHFNILKPYIKIFNRSVNIMH 9112
11018 DKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 11140
11921 RPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGWRFRRACRLVHDFTDAVIQERRH 12100
12101 TLPTQGI 12121
12115 CDFLKNKAKS*TLDFIDVLLLSKXXXXXXXXXXXXXXXXXXXXXX 12189
13460 GHDTTASGLSWVLYNLARHPEYQEHCRQEVQELLKDRDPKEIEWX 13591
21804 DLAQLPFLTMCVKESLRLHPPVPYTSRHRIWDIVLPDGRVIPK 21932
22019 GIICIINIIGIHHNPTV*PDPEV 22165
22263 YNPFRFNSENSKERSPLAFIPFSAGPR 22361

CYP4F25P   human = CYP4F-se1[6:8]
           GenEMBL AC018949 
           62% to 4F3 pseudogene
95242 LWRCFLSPTSPCRNPSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDL 95066
95065 VHNF 95054
95052 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 94936
           GenEMBL NT_078056.1|Hs9_78125 chromosome 
Query: 1     PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
             PSEYIAT+ ELSALIV* HQQICLC DFLYY  PEG CFCRACDLVHNF
Sbjct: 65960 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 66106

Query: 50    DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
             DTIILE+ CTLTSQGV DFL  KATFK +DFSDA VL K
Sbjct: 66108 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 66224

Query: 111   GYDSTATGLY*ILCNLRRHP 130
             GYDSTA+GLY IL  LRRHP
Sbjct: 66811 GYDSTASGLYWILVPLRRHP 66870

Query: 131   GVMPSCGARVLRDHNPEDIEW 151
             GV+P  GARVLRD N EDIEW
Sbjct: 66878 GVLPPRGARVLRDGNSEDIEW 66940

CYP4F26P   Human = CYP4F-se2[6]
           GenEMBL AL139008 
           Homo sapiens chromosome 9 clone RP11-255A11 81% TO CYP4F-se1[6:8]
           NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 
           Length = 39435727
Query: 2        SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
                S+Y+AT+ EL ALIV*WHQQICLCMDFLYY  PEG CFCRA DLVHNF
Sbjct: 33593291 SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF 33593434

Query: 50       DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
                DTIILEQ CTLTSQ V D LK +ATFKT DF DALVL K
Sbjct: 33593436 DTIILEQHCTLTSQSV-DILKARATFKTLDFIDALVLSK 33593549

CYP4F27P   human = CYP4F-se3[6:7:8]
           GenEMBL AC018804.2 
           Chr2:130805998-130806965 (-) strand
           Homo sapiens clone RP11-397H17 62% TO CYPF25P
           New name/synonym = CYP4F-se3[6:7:8]
           because the HGNC has strict rules for gene names,
           The old names (CYP3A51P, etc.) are being used by the HGNC
           These will be synonyms. 
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171

CYP4F28     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_2425
            76% to 4F7 
8381 MSVLQLALSWTSVCPLLAVLAAAPVALLTFWTAKLLVRHAWYTHRMACFSKPHARSWLLGHLGQ 8190 (0)
7561 MQSTEEGLLQVDELVQMFTYCCSWFIGPFYHLVRVFHPDYVKPLLMAP 7418 (1)
7238 ASITVKDELIYDHLRPWL 7185 (1)
7049 GNSLLLSNGEAWSRRRRLLTPAFHFDILKNYVTKFNTSTNTLH 6921 (0)
6727 DKWHRLLVEGTTNIEVFEHFTLMTLDSLLKCAFSYDSDCQQ 6605 (2)
6527 SSSEYASAIIELSDLIIERRQRILHHWDWIYWRTQQGKRFKKALSIVHK 6381 (2)
6307 FTRDVVQKRLALISQKGVAELAAHRKRDFVDIILLTK 6197 (0)
6115 DEDGKGLTDEELQAEANTFMFA 6050 (1)
5813 GHDTTASAICWSLYNLAHHNHYQEQCRQEVMDLMEGRDVDEIKW 5682 (2)
5607 EDLSSLPFTTMCIRESLRLHSPVQAVTRRYIQDVKLPGERTVPK 5476 (1)
5248 GAICLVSIYGTHHNPAVWTNPH 5183 (0) 
5101 DFDPLRFDPKNQEGLSSHAFIPFSSGPR 5018 (2)
4948 NCIGQKFALAELRVVVALTLLRFRLLPGNDPKRETPFEKVRRLPQLVLRAEGGLWLQIKPVTQTQ* 4751

CYP4F28     Tetraodon nigroviridis (freshwater puffer) 
            84% to fugu CYP4F28 (ortholog)
MTVLQLLAALGAGLCAGLCALLAFWTAKLLVRHAWYTHRMSCFSRPHARSWLLGHLGQ (0)
MQSTEEGLLQVEELVQMFTYCCSWFIGPFYHLLRVFHPDYVKPLLTAS (1)
ASITVKDELIYGHLRPWL (1)
GRSLLLSNGEVWLRKRRLLTPAFHFDILKNYVAKFNTSTNTMH (0)
DKWRRLAAEGPTHVEAFEDVTLMTLDSLLKCAFSYDSDCQQ (2)
SSSEYASAIVQLSDLIIERRQRILHHWDWIYWRTRQGKRFQQALSIVHK (2)
FTRDVVQERRTLIGQKGEMAAQGKKDFVDIILLSK (0)
DEDGKGLTDEEIQAEANTFMFA (1)
GHDTTASAICWSLYNLARHDHYQEKCRKEVMDLMEGRDVHEINW (2)
EDLSSLPFTTMCIRESLRLHSPVQAVTRRYLQDVELPGGHTVPE (1) 
GAICLVSIYGTHHNPAVWTNPH (0)
DFDPLRFDPTNQKGLSSHAFIPFSSGPR (2)
NCIGQKFALAELRVVVALTLLRFRLSPGRDPRLGTTSGKVRRLPQLVLRAEGGLWLQVEPVTPAQ*

CYP4F29P    human = CYP4F-se4[6:7:8]
            AL109748 chr 21 
            designated CYP4F3LP pseudogene Nature 405, 311-319 2000 
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW

CYP4F30P    human = CYP4F-se9[6:7:8]
            NT_022140.9|Hs2_22296 Homo sapiens chromosome 2 
270169 RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLTSQGVDDFLKAKATFKA 269990
269989 SDFIDALVLSK 269957

CYP4F31P    human = CYP4F-se10[6:7:8]
            NT_019306.9|Hs2_19462 Homo sapiens chromosome 2 
2940797 PEG*CFYKACDLVHNF 2940844

CYP4F32P    human = CYP4F-se5[6:8]
            NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to CYP4F-se1[6:8]
            New name = CYP4F-se5[6:8]
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
            NT_022300.8|Hs2_22456 chromosome 2 88% to 4F25P
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845

CYP4F33P    human = CYP4F-se6[6]
            NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
            NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 genomic contig
            Length = 39435727
Query: 2        SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTLT 61
                S+Y+AT+ EL ALIV*WHQQICLC DFLYY  PEG CFC         DTIILE+ CTLT
Sbjct: 38532567 SDYVATILELHALIV*WHQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLT 38532388

Query: 62       SQGVHDFLKTKATFKTWDFSDALVLGK 88
                SQGV D LK KATFKT DF DALV  K
Sbjct: 38532387 SQGV-DVLKAKATFKTLDFIDALVPSK 38532310

CYP4F34P     human = CYP4F-se7[6:7:8]
             NT_009799.9|Hs13_9956 Homo sapiens chromosome 13 
343178 DTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
             NT_009799.9|Hs13_9956 chromosome 13 4F pseudogene 78% to 4F27P
             Old name = 4F34P
343270 HQQICLCMDFLYYXX 343232
343226 PDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
             NT_009799.12|Hs13_9956 Homo sapiens chromosome 13 genomic contig
             Length = 12392145
Query: 1      PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 33
              PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
Sbjct: 296823 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 296725

Query: 32     PFPEG*CFCRACDLVHNFDTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
              P P+G             DTIILEQ CTLTSQGVHDFLK KATFKT DFSDAL+LGK
Sbjct: 296731 PIPDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 296561

Query: 88     KDENGKELSDEDI*MEAGIFMST 110
              +DENGKELSDEDI*MEA IFMST
Sbjct: 296237 QDENGKELSDEDI*MEADIFMST 296169

Query: 111    GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
              GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRD NPEDIEW
Sbjct: 295991 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDRNPEDIEW 295869

CYP4F35P    human = CYP4F-se8[6:7:8]
            NT_010859.8|Hs18_11016 chromosome 18 4F pseudogene 84% to 4F12
            chr18p11.21 14328070-14328279 + strand build 33
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
            NT_010859.12|Hs18_11016 Homo sapiens chromosome 18 Length = 14719514
Query: 1        PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTL 60
                PSEYIATLFELSALIV*WHQQICLCMDFLYYPF  G             DTIILEQ CTL
Sbjct: 14328016 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTL 14328195

Query: 61       TSQGVHDFLKTKATFKTWDFSDALVLGK 88
                TSQGVHDFLK KATFKTWDFSDALVLGK
Sbjct: 14328196 TSQGVHDFLKAKATFKTWDFSDALVLGK 14328279

Query: 88       KDENGKELSDEDI*MEAGIFMST 110
                +DENGKELS+EDI*MEAGIFMST
Sbjct: 14328531 QDENGKELSEEDI*MEAGIFMST 14328599

Query: 111      GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
                GY+STATGLY*ILCNLRRHPGVMPS GARVLRD NPEDIEW
Sbjct: 14328777 GYESTATGLY*ILCNLRRHPGVMPSRGARVLRDRNPEDIEW 14328899

CYP4F36P    human = CYP4F2-de12b
            NT_011281.4|Hs19_11438 chromosome lone last exon 75% TO 4F11
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448

Cyp4f37     mouse
            AC073754 comp(28012-47256) also NT_039649.1
            93% identical to 4f16, duplicate exon 6, fs in exon 7 
MLRLSVSGLDLGSVVTLSWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQPPKRNWFLGHLGM
IEHNEEGMQLMTEAGQTYRDVHLCWLGPVIPVLRIVDPAFVAPLLLA TALVAPKDTTFHTFVKPWL
GDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH
AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE
SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR
ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK
DEHGKELSDEDIRAEADTFMFGG
HDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW
DDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VYDPFRFDPENAHKRPPLAFIPFSAGP
RNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLS

Cyp4f37-ie6b mouse
           GenEMBL NT_039649.1 duplicate exon 6, incomplete
           x in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
9192951 SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHPADGR 9193064
9193067 FRKACD 9193084

>Cyp4f37-de1b mouse
           GenEMBL NT_039649.1|Mm17_39689_30 + strand 
           exon 1 22-60
           z in Figure 4D Nelson et al. Pharmacogenetics 14, 1-18 2004.
9142319 LLPFMAS*PLGRILAWTHFFYEVCACLICFPQAPKQNWF 9142435

>Cyp4f37-de7b8b mouse
           GenEMBL NT_039649.1|Mm17_39689_30 + strand 
           exons 7, 8
           y in Figure 4D Nelson et al. Pharmacogenetics 14, 1-18 2004.
9166323 DERGKELSDEDIWAEAYTFVFGR 9166391
9168358 XXXXXXALSWILYNLVRHPEYPECCLWEVQELLRDLNHEEIEX 9168465

Cyp4f37  rat 

Cyp4f38-ps   mouse
             AC073754 comp(9555-20475) also NT_039649.1
             partial pseudogene 52% to 4f14
AHILIQVYAAYGNYPHIPKWNWLMGHVSM
PQRRARRMLLNW*GNYP*GFIL*MIPLVSILKPCHPGIAKSV
VSAGDKWSHHCHMLTPAFHFNILKLYVKIFNDSTNIVH
LNISDHVILMTLGNFQKCIFSFDSNCQD
AIMELSMLISRRNKEPLLHMDLLGHLTPDGMCCCKACSMMHGLDDAVI
QERGHILSRQGLDGFFKDKVKFKPLNFIAVLLLTK
DDMSQLPFLTMCISLWLHPPDLLISYYCI*DVVLPDGWIIPKG

Cyp4f39      mouse
             AC073754 range 185296-209241, also NT_039649.1
             minus strand 62% to 4F14
MLPLTDYLLQLLGLEKTAFRVYV
VSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMVS
PNEKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGAS
AAIAPKDEFFYSFLKPWLG
DGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMH
AKWRRHLAEGSVTSFDMFEHISLMTLDSLQKCVFSYNSDCQE
SMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQACDTVHNFTTEVI
QERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAK
DEEGKELSDEDIRAEADTFMFEG
HDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDW
DDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRVIPK
GIICLVSIYGTHHNPIVWPDSK
VYNPYRFDPDTPQQRSPLAFVPFSAGP
RNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENGLWLNVEPLPSRA*

Cyp4f39  rat 

Cyp4f40      mouse
             AC073754 range <1-3688, also NT_039649.1 
             minus strand two N-terminal exons no ESTs
             continues on AC073720 comp(118300-137027) 79% to 4F14
MRYLDLSWLGLGPMSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMVS
PTEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSAS
SAAVAPKDDIFYSFLKPWL
GDGLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMH
AKWLRLASGGSTRLNMFENISLMTLDTLQKCVFSFNSNCQE
KPSQYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRLVHDF
TDAVIQERRRTLLKHGGDDIIKAKAKSKTLDFIDVLLLTK
DEDGKELSDEDIRAEADTFMFRG
HDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEW
DDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRIIPK
GVICIINIFGTHHNPTVWRDPE
VYDPFRFDPENIQARSPLSFIPFSAGP
RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSTQA

Cyp4f40  rat 

Cyp4f41-ps mouse
           GenEMBL NT_039649.1|Mm17_39689_30  - strand
           Pseudogene exons 5,6,9,10,12 189-216 
9523155 NKWQCLTFESSASL 9523114 
9523111 ALFEHMNLTTVDSLQKCVFSFHSNCQE 9523031
9521583 SNSKYIAAILELISFNSTSPSWMWTSCTNYLSVDG*CFHKACNLVDSFTDVVIT 9521422
9521421 TEGPCNLNTQGVDEFLKAKAKAKTLDFIDVLLKTR 9521317
9518053 NDLTQLPFLTMSMKESLRLHPPGSMISLCCIQDILLLDDLVISS 9517922
9517838 GHVC 9517827
9517828 VTSIFRSHHNPSVWPDPE 9517775
9517097 RNCIGLTFGHECNEDDDGADADAARFCVLPGDKGPRRLSALMLRTEGGLWLQVELLT 9516927

CYP4F42a   Xenopus laevis (African clawed frog)
           NM_001172179
           Yoshiaki Fujita and Hiroaki Ohi
           Submitted to nomenclature committee 7/1/2003
           64% to 4F22 in humans (full length)
MLPFLDHFLDSLNLSHSTFRVYIFYAVILFFSLIMFRTILKMVT
YIYAYIINARRLRCFPEPPRRSWLLGHLGLFMPTEEGLTEVSDAISSFRKTFLTWMGP
ISLVSVFHPDTVKPIVAASAAIAPKDDLFYGFLRPWLGDGLLLSHGEKWGRHRRLLTP
AFHFDILKSYVKIFNQSTDIMLAKWRRMTVEGPVSLDMFEHISLMTLDTLLKCTFSYD
SDCQEKPSDYIAAIYELSSLMVKREHYLPHHLDFIYNLSSNGRNFRQACKKVHEFTAG
VVQQRQKALKEKGMEEWIKSKQGKTKDFIDILLLSKVEDGNQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLARHPEYQEKCRKEIIELLEGKILKHLEWDELSQLPFTTMCIK
ESLRLHPPVTAVSRRCTEDIKLPDGKVIPKGNTCLISIYGTHHNPEIWPNPQVYDPYR
FDPENVQERSSHAFVPFSAGPRNCIGQNFAMAEMKIVLALILYKFHVRLDETKAVRRK
PELILRAENGLWLQVEELKR

CYP4F42b   Xenopus laevis (African clawed frog) 
           SwissProt A0AUU0 
           86% to CYP4F42a presumed ohnolog due to genome duplication
MLQFLDHFLDSLNPSHTTFRVYIFAAIILIFSLIIFRTILKMVKFIYAYIINARRLRCF
PEPPRRSWLLGHMGLIKNTEEGLLVVDSLVKTYIYACSWWFSLCYPIVRLFHPSSIKPI
LQVSAAIAQKDELFYGFLRPWLGDGLLLSHGEKWGRHRRLLTPAFHFDILKNYVKIFNQ
STDIMLAKWRRLAVEGPVSLDMFEHVSLMTLDTLLKCTFSYDSDCQEKPSDYITAIYEL
SSLVVKREHYLPHHFDFIYNLSSNGRKFRLACKKVHKFTAGVVQQRKKALQETGAEEWI
KSKQGKTKDFIDILLLSKDEDGNQLSDEDMRAEVDTFMFEGHDTTASGLSWILYNLARH
PEYQEKCRKEITELLEGKDTKHLEWDELSQLPFTTMCIKESLRLYPPVTAISRRCTEDI
KLPDGKVIPKGNSCLISIYGTHHNPEVWPNPQVYDPYRFDPEKLQERSAHAFVPFSAGP
RNCIGQNFAMAEMKIVLALTLYNFHVRLDETKPVRRKPELILRAENGLWLQVEELKS

CYP4F43P   rat
pseudogene chr7 (+) strand exons 4, 5, 9, 10, 11, 12
between 4F37 and 4F40
13179984 RDGVFLISFDKWNHHHCLLTPAFHFDNLVL 13180073
         *VKIFNQSVNIIH
13181413 VSFLKAKWKCLFSEGSACLEIFENLTTLDSLQKCLFSLDSNCQE 13181544

13207589 NDLAQLPFLTMCIKASLQLYPQDTNLICSCT 13207681
         *DILLPDG*VIPK
         XXXXXXXXXGVHHSPSVWTDPX
13208327 VYYPFPFDSKNPQKISPLAFMPFSVGP 13208407
13208782 RNCKRQTYPMSERKVALVLKLLHFHTIPGEIDPPRQPELILSLEGRLWLLKESLSVG 13208952

CYP4F44P human = CYP4F-se12[6:8] name conflict with rat
           NT_008251.13|Hs8_8408 Homo sapiens chromosome 8 genomic contig
           Length = 5847381 
           chr8P11.1 43132635-43132941 + STRAND BUILD 33
Query: 1       PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
               PS+YIAT+ ELSALI+*  QQI L  DFLYY   EG CFCRAC +VHNF
Sbjct: 5439042 PSDYIATILELSALIM*RQQQIFLHRDFLYYVTAEGWCFCRACVVVHNF 5439188

Query: 50      DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
               DTIILEQ CTLTSQGV++FLK  ATFKT DF D LVL K
Sbjct: 5439190 DTIILEQHCTLTSQGVNNFLKVTATFKTLDFIDVLVLDK 5439306

Query: 111     GYDSTATGLY*IL 123
               GYDSTA+GL+ +L
Sbjct: 5439892 GYDSTASGLFWVL 5439930

Query: 131     GVMPSCGARVLRDHNPEDIEW 151
               GV+P+ GA VLRDH+PEDIEW
Sbjct: 5439959 GVLPALGAGVLRDHSPEDIEW 5440021

CYP4F44P   rat (name conflict with human CYP4F44P)
pseudogene MISSING EXON 1 AND HALF OF EXON 2 90% to 4f16
between 4F37 and 4F40
13215861 LGPVIPVLRLVDPAFVAPLLQAP 13215929
13219942 ALVAPKDMNFYGFLKPWL 13219995
13220082 GDGLLLSSGDKWNRHRXLTPAFHFDILKPYVKIFNQSVNIMH 13220206
13227610 VKWKHLCVEGSAHLEMFENISLMTLDSLQKCLFGFDSNCQE 13227732
13228571 SPSEYISAILELSSLTIKRSYQLFLYLDFLYYRTADGRRFRKAC
         DLVHSFTDAVIRERRRLLSSQGVDEFLESKTKSKSKTLDFIDVLLLAK 13228846
13230087 DEHGKELSDEDIRAEADTFMFG 13230152
13230344 GHDTTASTLSWILYNLARHPEYQESCLQEVWELLRDREPEEIEW 13230475
13239583 DDLAQLPFLTMCIKESLRLHPPAVDLLRRCTQDIVLPDGRVIPK 13239714
13239826 GNICVISIFGIHHNPSVWPDPE 13239891
13240051 VYDPFRFDPESRQKRSPLSFIPFSAGP 13240131
13240378 RNCIGQTFAMNEMKVAVALTLLRFRLLPDDKEPRRKPEIILRAEGGLRLLVEPLSGGA* 13240554

CYP4F45P human = CYP4F-se13[6:8] (name conflict with macaque) 
            AC018949 62% to 4F3 pseudogene
            found in two places 100% match
            CYP4F-se1[6:8]  chr9p11.2 43742181-43742487 (4F25P) + strand build 33
            CYP4F-se13[6:8] chr9q13   63753376-63753682 (4F45P) + strand build 33
            NT_078070.1|Hs9_78139 Homo sapiens chromosome 9 genomic contig
            Length = 423701 
Query: 1     PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
             PSEYIAT+ ELSALIV* HQQICLC DFLYY  PEG CFCRACDLVHNF
Sbjct: 34719 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 34865

Query: 50    DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
             DTIILE+ CTLTSQGV DFL  KATFK +DFSDA VL K
Sbjct: 34867 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 34983

Query: 111   GYDSTATGLY*ILCNLRRHP 130
             GYDSTA+GLY IL  LRRHP
Sbjct: 35569 GYDSTASGLYWILVPLRRHP 35628

Query: 131   GVMPSCGARVLRDHNPEDIEW 151
             GV+P  GARVLRD N EDIEW
Sbjct: 35636 GVLPPRGARVLRDGNSEDIEW 35698

CYP4F45/4F2 Macaca fasicularis (cynomolgus monkey)
            DQ074798
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP4F2#1
            87% to 4F11 human, 88% to 4F2 and 87% to 4F3 
            needs a separate name. Cannot identify the ortholog without map data
            based on the rhesus genome this is probably the CYP4F2 ortholog
MSQLSLSWLGLGPVAVSPWLLLLLVGTSWLLARVLAWTYTFYDN
SRRLRGFPQPPKRNWFWGHQGMVKSTEEGMRVLTQLVATYPQGFRVWMGPVFPLLSLC
HPDIIRSVINASAAIVPKDKLFYRFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL
KPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
SEYIAAILELSALVSKRHQQFLLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVEDFLQAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTA
SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLH
PPVPVISRRVTQDIVLPDGRVIPKGITCLLSVFGTHHNPTVWPDPEVYDPFRFDPENI
KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA
EGGLWLRVEPLS

CYP4F46     Bos taurus (cow)
            See cattle page for details
MLELSMSRLGLGLVAASPWLLLLVVGASWLLAHILAWTYTFFNNCRLLQCFPQPPKLNWFFAHLYL (0)
VPMTEQGLRKLTQLAANYSHGYMIWFGPITLMIVFCHPDMLRSITNAS
AAVAPKDMDFYNFLKPWLG
DGLLLSAGDKWSRHRCMLTPTFHFNILKPYMKIFTKSTDIMH
TNWECLVTQGHTRLDMFEHVSLLTLDSLQKCVFSFDSNCQE
KPSEYITTIFELCELAAKRNKQICLHTDFLYFLTLDGWHFRRACRLVHNFTDSIIQEQRCTLPSENI
DDFFKAKVKTKTLDFIDVLLLSK
DEDGKGLSDEE
IRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCGQEVKELLRDCESKEIEW
DDLAHLPFLTMCIKESPRLHPPVTFIFRYCTQDIVLPDGRVIPK
GVVCLIDIFGTHHNPSVWPDPE
VYDPFRFDPENIKGRSPLAFIPFSAGSR
NCIGQTFAMTEMNVVLALTLLRFRFRPDKEEPRRKPELILRAEGGLWLQVELLSAGPQ*

CYP4F47     Bos taurus (cow)
            See cattle page for details
MLELSLSWLGLRPVAASPWLLLVLVGASWILAHVLAWTYTFYNNSRHLQCFPQPPKRNWFLGHMGQYPP
TEKGLRDFTQLVANYPQGFRICLGPAIPIIIFCHPDMIRIVANAS
AAAAPKDVIFYDFLKPWLG
DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFTKSADIMH
AKWQRLITEGHTHLDMFEHISLMTLDSLQKCVFSYDSNCQE
KPNEYIASILELSALVAKRNQQIFLHMDFLYFLTPDWRRFRRACRLVHDFTDAVIQERRHTLPSEGT
DDFLKAKVKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWVLYNLAKHPEYQERCRQEVQDLLRDRESKEIEW
DDLAQLPFLTMCIKESLRLHPPVSVISRRYAQDTLLPDGRVIPK
GVICLINIIGTHHNPSVWPDPE
VYDPFRFEPENIKGRSPLAFIPFSVGPR
NCIGQTFAMTEMKVVLALTLLRFRVLPGEEPRRKPELILRAEGGLWLRVEPLSADQ

CYP4F48     Bos taurus (cow)
            See cattle page for details
MLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNL
VPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNAS
AAIAPKDMQFYGTLKPWLG
DGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMH
AKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQE
KPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENI
DDFLKAKAKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEW
DDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPK
GVVCLIDIFGTHHNPSVWQDPE
VYDPFRFDPENIKGRSPLAFIPFSAGPR
NCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ*

CYP4F49     Bos taurus (cow)
            See cattle page for details
MLELSLSWLGLGPVAASPWLLLLFTGASWLLARILAWTYTFYNNSRRLQCFPQPPKRNWFLGHLGL
VPPTEQGMSKLTELVAKYSQGFRIWMGPITPIIVFCHPDLIRIVANAS
AAVAPKDVIFYEVLKPWLG
DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFTKSTDIMH
AKWQHLIKEGHTHLDMFEHISLMTLDSLQKCIFSYDSNCQE
KPSEYIAAILELSALVAKRHQEIFLHMDFLYYLTPDGRRFRRACRLVHDFTDAVIQERHRTLPSESI
DDFLKAKAKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHKEYQERCRQEVQELLKDREPKNIEW
DDLAQLPFLTMCIKESLRLHPPVSVISRRCTQDTVLPDGRVIPK
GVICLISIFGTHHNPSVWPDPE
VFDPFRFDPENIKGRSPVAFVPFSVGPR
NCIGQTFAMTEMKVVLALTLLRFRVLPDKEEPRRKPELILRAEGGLWLRVEPLSTGQQ*

CYP4F50     Bos taurus (cow)
            See cattle page for details
MLELSLSWLGLGPVAASPWLLLLLVGASWILARILAWIYAFYDNCCRLRCFPQPPKRSWFWGHLGL
AQSNEESMRLVEELGHYFRDVHLWWMGPFFPILRLVHPNFVAPLLQAS
ATIIPKDMFFYSFLKPWLG
DGLLLSAGDKWSSHRRLLTPAFHFEILKPYMKIFNKSADIMH
AKWQRLALEGSTRLDMFEHISLMTLDSLQKCVFSYDSNCQE
KPSEYIAAILELSALVMKRIKHIFLHVDFLYYLTRDGQRFYRACRLVHDFTDAIIQKRRRTLISQGS
QEFLKTKTKAKTLDFIDVLLLAK
DEDGKGLPDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDREPKEIEW
EDLAQLPFLTMCIKESLRLHPPVAVISRLCTHDVVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VFNPFRFDPEAPKRSPLAFIPFSAGPR
NCIGQTFAMNEMKVALALTLLRFRILPDEEEPRRKPELILRAEGGLWLQVEPLNTGQ*

CYP4F51   Danio rerio (zebrafish)
          See zebrafish page for seq

CYP4F52   Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          77% to human 4F11, 81% to 4F49 cow
          only 1 aa diff to AK233364 complete seq.
          partial seq.

CYP4F52   Sus scrofa (pig) 
          AK233364
          2 aa diffs to AK233483
MLQLSLSWLGLGPVEASPWLLLLLVGASWLLARVLVWTCTSLDNV
RRLRGFPQPPKPNWLLGHMGQVPPTEEGMTKLTQMMNTYPNGFMIWMGPITPIIVLCHPD
LIRTMANASAAVAPKDVVFYDFLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYMK
IFNDSVNVMHAKWQRLVTEGHNRLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYIAAI
LELSALVAKRHQQIFLHLDFLYYLTPDGWRFHKACRLVHDFTDAVIQERRNTLPTEGIDD
FLKAKAKAKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWVLYNLA
KHPEYQERCRQEVHELLRDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQD
IVLPDGRIIPKGVICLISIFGTHHNPLVWQDPEVYDPFRFDPENIKERSPLAFIPFSAGP
RNCIGQTFAMTEMKVVLALTLLRFRVLPVEEEPRRKPELILRAEGGLWLRVEPLSASPQ*

CYP4F53    pig
           AK230568 
           85% to AK233364
MLQLSLSKMGLWLMAASPWLLLLLVGASWLLVQVLVW
TYTSYDNARRLRGFPQPPKRNWFLGHLGLIQSSEEGLLYTQDLASTYGDVCCWWVGPWHA
VIRIFHPTYIKPVLFAPAAIAPKASVFYDFLKPWLGDGLLLSAGDKWSSHHRMLTPAFHF
NILKLYMKNFNDSVNVMHAKWQHLVTEGHNRLDMFEHISLMTLDSLLKCVFSFHSNCQEK
PSQYIAAIVELSALVAKRHQQIFLHLDFLYYLTPDGWRFHKACRLVHDFTDAVIQERRNT
LPTEGIDDFLKAKDKAKTLDFIDVLLLTKDEDGKRLSDEDIRAEADTIMFGDHDTTASGL
SWVLYNLAKHPEYQECCRQEVHELLRDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVTV
ISRRCAQDIVLPDGRIIPKGVICLISIFGTHHNPSVWPDPEVYDPFRFDPENIKGRSPLA
FIPFSAGPRNCIGQTFAMTEMKVVLALTLLHFRVLPDKEEPRRKPELILRAEGGLWLQLE
PLSAGQQ*

CYP4F54    pig
           AK238099 
           95% to AK233210 22 diffs
MLQLSLSWLGPGPVSASPWLLLQLVGATWLLSRILS
WIYDFYDNCCRLRCFPQPPKRNWFWGHWDLAKSNEEGLQLIEDMGRLFCDVYLWWLGPFY
PILRLVHPNFVAPLLQAPATIIPKDMLFYSFLKPWLGVGLLLSAGEKWSHQRRLLTPAFH
FDILKSYVKIFNRSADIMHAKWQRLASEGHTRLDMFEHISLMTLDSLQKCVFSFDSNCQE
KPSEYITAILALSALVIKRCEQIFLHKDFLYYLTPEGRRFRKACRLVHDFTDAVIQERRC
TLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIRAEADTFMFAGHDTTASG
LSWVLYNLAKHPEYQERCRKEVQELLRDREPKEIEWDELAQLPFLTMCIKESLRLHPPVP
GISRCCAQDVVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYNPFRFDPESPQKRSPL
AFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPRRKPEIVLRAEGGLWLRV
EPLRGGQQ*

CYP4F55   Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          Three partial sequences called CYP4F6v1a,
          CYP4F6v1b and CYP4F6v2 each have only 1 or 2
          Amino acid diffs to the complete seq AK233210
          These all appear to be from a single gene

CYP4F55v1 Sus scrofa (pig)
          AK233210 
          5 aa diffs to AK239242 allele?
MLQLSLSWLGLGPVSASPWLLLQLVGATWLLSQ
ILSWIYDFYDNCCRLRCFPQPPKRNWFWGHRDLAKSNEECLQLMEDVGHYFHDVYLWWLG
PFYPILRLVHPNFVAPLLQAPATIIHKDMFLYIFLKPWLGVGLLLSAGEKWSHQRRLLTP
AFHFDILKSYVKIFNRSADIMHAKWQRLASEGHTRLDMFEHISLMTLDSLQKCVFSFDSN
CQEKPSEYIAAISELSALVTKRNEQIFLHKDFLYYLTPEGRRFRKACRLVHDFTDAVIQE
RRRTLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIRAEADTFMFAGHDTT
ASGLSWVLYNLAKHPEYQERCRQEVQELLRDREPKEIEWDELAQLPFLTMCIKESLRLHP
PVTGISRCCTQDVVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYNPFRFDPESPQKR
SPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPRRKPEIVLRAEGGLW
LRVEPLRGGQQ*

CYP4F55v2 Sus scrofa (pig)
          AK239242, AK232426 
          5 aa diffs to AK233210
MLQLSLSWLGLGPVSASPW
LLLQLVGATWLLSRILSWIYDFYDNCCRLRCFPQPPKRNWFWGHQDLAKSNEECLQLMED
VGHYFHDVYLWWLGPFYPILRLVHPNFVAPLLQAPATIIHKDMFLYIFLKPWLGVGLLLS
AGEKWSHQRRLLTPAFHFDILKSYVKIFNRSADIMHAKWQHLASEGHTRLDMFEHISLMT
LDSLQKCVFSFDSNCQEKPSEYIAAISELSALVTKRNEQIFLHKDFLYYLTPEGRRFRKA
CRLVHDFTDAVIQERRRTLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIQ
AEADTFMFAGHDTTASGLSWVLYNLAKHPEYQERCRQEVQELLRDREPKEIEWDELAQLP
FLTMCIKESLRLHPPVTGISRCCTQDVVLPDGRIIPKGNICVISIFGIHHNPSVWPDPEV
YNPFRFDPESPQKRSPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPR
RKPEIVLRAEGGLWLRVEPLRGGQQ*

CYP4F56   Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          84% to 4F3 human, 88% to 4F49 cow, 94% to CYP4F52
          15 aa diff to AK233364 CYP4F52 complete seq.
          partial seq.

CYP4F57v1   Xenopus tropicalis (Western clawed frog)
            AL648475.2, CF786466.1, AL896688.2 
            NM_001016020.2 
            62% to 4F22, 1aa different to NM_001015770
            90% to NM_001015810, same as DT404766.1
            87% to CYP4F42 X. laevis
            CYP4F57 and CYP4F58 are adjacent and seem to be co-orthologs 
            of CYP4F42 Xenopus laevis
MLPFLDHFLDSLNMSRTSFRVYIFAAVILMFCLIMCRTIFKMAI
YIYAYIINARRLRCFPEPPRRSWLLGHLGMFMPTEEGLTEISSAICNLRRTLLTWLGP
IPEVSLVHPDTVKPVVAASAAIAPKDELFYGFLRPWLGDGLLLSRGEKWGQHRRLLTP
AFHFDILKNYVKIFNQSTDIMLAKWRRLTAEGPVSLDMFEHVSLMTLDTLLKCTFSYD
SDCQEKPSDYISAIYELSSLVVKREHYLPHHFDFIYNLSSNGRKFRQACKTVHEFTAG
VVQQRKKALQEKGMEEWIKSKQGKTKDFIDILLLSKNEDGSQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLACHPEYQEKCRKEITELLEGKDIKHLEWDELSKLPFTTMCIK
ESLRLHPPVVAVIRRCTEDIKLPKGDILPKGNCCIINIFGIHHNPDVWPNPQVYDPYR
FDPENLQERSSYAFVPFSAGPRNCIGQNFAMAEMKIVLALILYNFQVRLDETKTVRRK
PELILRAENGLWLQVEELKR

CYP4F57v2   Xenopus tropicalis (Western clawed frog)
            CX980073.1, CX968437.1, CF589328.1
            NM_001015770.1 
            62% to 4F22
            note there are two seqs that differ at only 2 nucleotides
            but there are three ESTs that support each sequence so these
            are probably alleles.
            88% to CYP4F42 X. laevis
            scaffold 403 669820-690787 (-) strand
            CYP4F57 and CYP4F58 are adjacent and seem to be co-orthologs 
            of CYP4F42 Xenopus laevis
MLPFLDHFLDSLNMSRTSFRVYIFAAVILMFCLIMCRTIFKMAT
YIYAYIINARRLRCFPEPPRRSWLLGHLGMFMPTEEGLTEISSAICNLRRTLLTWLGP
IPEVSLVHPDTVKPVVAASAAIAPKDELFYGFLRPWLGDGLLLSRGEKWGQHRRLLTP
AFHFDILKNYVKIFNQSTDIMLAKWRRLTAEGPVSLDMFEHVSLMTLDTLLKCTFSYD
SDCQEKPSDYISAIYELSSLVVKREHYLPHHFDFIYNLSSNGRKFRQACKTVHEFTAG
VVQQRKKALQEKGMEEWIKSKQGKTKDFIDILLLSKNEDGSQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLACHPEYQEKCRKEITELLEGKDIKHLEWDELSKLPFTTMCIK
ESLRLHPPVVAVIRRCTEDIKLPKGDILPKGNCCIINIFGIHHNPDVWPNPQVYDPYR
FDPENLQERSSYAFVPFSAGPRNCIGQNFAMAEMKIVLALILYNFQVRLDETKTVRRK
PELILRAENGLWLQVEELKR

CYP4F58    Xenopus tropicalis (Western clawed frog)
           NM_001015810.1 
           64% to 4F22
           90% to CYP4F42 X. laevis, 
           90% to CYP4F57v1 and CYP4F57v2
           scaffold 403 641462-661033 (-) strand
           CYP4F57 and CYP4F58 are adjacent and seem to be co-orthologs 
           of CYP4F42 Xenopus laevis
MLPSLDHFLDSLNMSRSSFRVYIFAAVILLFCLIMFRTILKMAI
YIYAYIINARRLRCFPEPPRRSWLLGHLGLFMPTEEGLTEVSNTISNFRKSFLTWMGP
ISLVSMVHPDTIKPMVAASAAIAPKDELFYGFLRPWLGDGLLLSRGEKWGRQRRLLTP
AFHFDILKNYVKIFNQSTDIMLAKWRRLAAVGPVSLDMFEHVSLMTLDTLLKCTFSYD
SDCQEKPSDYIAAIYELSSLVVKREHYLPHHFDFIYNLSSNGRKFHQACKTVHEFTAG
VVQQRKKALQEKGIEEWIKSKQGKTKDFIDILLLSKDEDGNQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLACHPEYQEKCRKEITELLEGKDTKHLEWDELSQLPFTTMCIK
ESLRLHPPVTAVSRRCTEDIKLPDGKVIPKGNSCLISIYGTHHNPDVWPNPQVYDPYR
FDPEKLQERSSHAFVPFSAGPRNCIGQNFAMAEMKIVLALTLYNFYMRLDETKTVRRK
PELILRAENGLWLQVEELKQ

CYP4F59P     human = CYP4F-se14[6:8]
             Chr9:43030439-43031461 (-) strand
             
CYP4F60P     human = CYP4F-se15[6:7:8]
             Chr9:44019570-44020591 (-) strand
             
CYP4F61P     human = CYP4F-se16[6:7:8]
             Chr9:66367007-66368028 (-) strand
             
CYP4F62P   human CYP4F-se11[6;7:8]
           NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
           Length = 18291257 
           chr2q21.1 131461272 131461568 5 DIFFS TO 27P 1 DIFF TO 4F32P
      CFLSLASPCRNA
47879 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLT 48058
48059 SQGVDDFLKAKATFKASDFIDALVLSK 48139
48462 QDENGKELSDEDI*MEAGIFMSAG 48533
48727 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 48846

CYP4F63P     human = CYP4F2-ie2b

CYP4F64P     human = CYP4F3-ie2b

CYP4F65P     human 
             1 kb downstream of CYP4F44P

CYP4F-se1[6:8] human = CYP4F25P
           GenEMBL NT_078056.1|Hs9_78125 chromosome 9
           Length = 79560 

Query: 1     PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
             PSEYIAT+ ELSALIV* HQQICLC DFLYY  PEG CFCRACDLVHNF
Sbjct: 65960 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 66106

Query: 50    DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
             DTIILE+ CTLTSQGV DFL  KATFK +DFSDA VL K
Sbjct: 66108 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 66224

Query: 111   GYDSTATGLY*ILCNLRRHP 130
             GYDSTA+GLY IL  LRRHP
Sbjct: 66811 GYDSTASGLYWILVPLRRHP 66870

Query: 131   GVMPSCGARVLRDHNPEDIEW 151
             GV+P  GARVLRD N EDIEW
Sbjct: 66878 GVLPPRGARVLRDGNSEDIEW 66940

CYP4F-se2[6] human = CYP4F26P
           GenEMBL NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 
           Length = 39435727
Query: 2        SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
                S+Y+AT+ EL ALIV*WHQQICLCMDFLYY  PEG CFCRA DLVHNF
Sbjct: 33593291 SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF 33593434

Query: 50       DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
                DTIILEQ CTLTSQ V D LK +ATFKT DF DALVL K
Sbjct: 33593436 DTIILEQHCTLTSQSV-DILKARATFKTLDFIDALVLSK 33593549

CYP4F-se3[6:7:8] human = CYP4F27P
           AC018804.2 Homo sapiens clone RP11-397H17 62% TO CYP4F-se1[6:8]
           chr2q21.1 Chr2:130805998-130806965 (-) strand
           because the HGNC has strict rules for gene names,
           The old names (CYP4F27P, etc.) are being used by the HGNC
           These will be synonyms. 
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171
           NT_005079.12|Hs2_5236 Homo sapiens chromosome 2 genomic contig
           Length = 4419942
3868414 SEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 3868235
3868234 SQGVDDFLKAKATFKASDFIDALVLSK 3868154
3867831 QDENGKELSDEDI*MEAGIFMSAG 3867760
3867566 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 3867447
           chr2q21.1 130711641-130711937
           4 DIFFS TO CYP4F-se3[6:7:8] 
Query:     1 CFLSLASPCRNASELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTS 180
             CFLSLASPCRNASE  ADILELSTLIV*RRQ ICLC DFLYYPFLRGDASAGPVTWCTTS
Sbjct:     4 CFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTWCTTS 63

Query:   181 DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 297
             DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK
Sbjct:    64 DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 102

CYP4F-se4[6:7:8] human = CYP4F29P
         AL109748 designated CYP4F3LP pseudogene 
         Nature 405, 311-319 2000 chr21q11.2 14140950-14141905 + strand build 33
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW

CYP4F-se5[6:8] human CYP4F32P
          NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to CYP4F-se1[6:8]
          chr2q11.1 94893656-94893866 + strand build 33
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
          NT_022300.8|Hs2_22456 chromosome 2 88% to CYP4F-se1[6:8]
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845
          NT_026970.9|Hs2_27130 Homo sapiens chromosome 2 genomic contig
          Length = 2594449
Query: 1     PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
             PSEYIAT+ ELSAL+V*WHQQICLC DFLYY  PEG CFCRA DLVHNF
Sbjct: 99822 PSEYIATILELSALLV*WHQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 99676

Query: 50    DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
             DTIILEQ  TLT +GV DFLK KATFK  DFSDA +L K
Sbjct: 99674 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 99558

Query: 110   TGYDSTATGLY*ILCNLRRH 129
             +GYDSTA+GLY IL NLRRH
Sbjct: 98986 SGYDSTASGLYWILYNLRRH 98927

Query: 131   GVMPSCGARVLRDHNPEDIEW 151
             GV+P  GARVLRD N EDIEW
Sbjct: 98916 GVLPPRGARVLRDRNSEDIEW 98854

CYP4F-se6[6] human = CYP4F33P
          NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
          chr9p13.1 38532310-38532516 + strand build 33
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
          NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 genomic contig
          Length = 39435727
Query: 2        SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTLT 61
                S+Y+AT+ EL ALIV*WHQQICLC DFLYY  PEG CFC         DTIILE+ CTLT
Sbjct: 38532567 SDYVATILELHALIV*WHQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLT 38532388

Query: 62       SQGVHDFLKTKATFKTWDFSDALVLGK 88
                SQGV D LK KATFKT DF DALV  K
Sbjct: 38532387 SQGV-DVLKAKATFKTLDFIDALVPSK 38532310

CYP4F-se7[6:7:8] human = CYP4F34P
             NT_009799.9|Hs13_9956 chromosome 13 4F pseudogene 78% to 4F27P
343270 HQQICLCMDFLYYXX 343232
343226 PDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
             NT_009799.12|Hs13_9956 Homo sapiens chromosome 13 genomic contig
             Length = 12392145
Query: 1      PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 33
              PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
Sbjct: 296823 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 296725

Query: 32     PFPEG*CFCRACDLVHNFDTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
              P P+G             DTIILEQ CTLTSQGVHDFLK KATFKT DFSDAL+LGK
Sbjct: 296731 PIPDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 296561

Query: 88     KDENGKELSDEDI*MEAGIFMST 110
              +DENGKELSDEDI*MEA IFMST
Sbjct: 296237 QDENGKELSDEDI*MEADIFMST 296169

Query: 111    GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
              GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRD NPEDIEW
Sbjct: 295991 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDRNPEDIEW 295869

CYP4F-se8[6:7:8] human = CYP4F35P
             NT_010859.8|Hs18_11016 chromosome 18 
             84% to 4F12 chr18p11.21 14328070-14328279 + strand build 33
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
             NT_010859.12|Hs18_11016 Homo sapiens chromosome 18 Length = 14719514
Query: 1        PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTL 60
                PSEYIATLFELSALIV*WHQQICLCMDFLYYPF  G             DTIILEQ CTL
Sbjct: 14328016 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTL 14328195

Query: 61       TSQGVHDFLKTKATFKTWDFSDALVLGK 88
                TSQGVHDFLK KATFKTWDFSDALVLGK
Sbjct: 14328196 TSQGVHDFLKAKATFKTWDFSDALVLGK 14328279

Query: 88       KDENGKELSDEDI*MEAGIFMST 110
                +DENGKELS+EDI*MEAGIFMST
Sbjct: 14328531 QDENGKELSEEDI*MEAGIFMST 14328599

Query: 111      GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
                GY+STATGLY*ILCNLRRHPGVMPS GARVLRD NPEDIEW
Sbjct: 14328777 GYESTATGLY*ILCNLRRHPGVMPSRGARVLRDRNPEDIEW 14328899


CYP4F-se9[6:7:8] human = CYP4F30P
           NT_005079.12|Hs2_5236 Homo sapiens chromosome 2 genomic contig
           Length = 4419942 = 
           chr2q21.1 131102500-131102796 
           2 diffs with 4F31P
4259273 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 4259094
4259093 SQGVDDFLKAKATFKASDFIDALVLSK 4259013
4258690 QDENGKELSDEDI*MEAGIFMSAG 4258619
4258425 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 4258306
Query:     1 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 60
             SE IADILELSTLIV*RRQ ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT
Sbjct:     1 SEHIADILELSTLIV*RRQ*ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 60

Query:    61 SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL 120
             SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL
Sbjct:    61 SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL 120

Query:   121 Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 151
             Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW
Sbjct:   121 Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 151

CYP4F-se10[6:7:8] human = CYP4F31P
           NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
           Length = 18291257 
           chr2q21.1 132067957-132068253 
           2 diffs with CYP4F30P
654564 SEHIADILELSTLIV*RRQ*ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 654743
654744 SQGVDDFLKAKATFKASDFIDALVLSK 654824
655147 QDENGKELSDEDI*MEAGIFMSAG 655218
655412 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 655531

CYP4F-se11[6:7:8] human = CYP4F62P formerly CYP4F43P but this is a rat seq.
           NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
           Length = 18291257 
           chr2q21.1 131461272 131461568 5 DIFFS TO 27P 1 DIFF TO 4F32P
      CFLSLASPCRNA
47879 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLT 48058
48059 SQGVDDFLKAKATFKASDFIDALVLSK 48139
48462 QDENGKELSDEDI*MEAGIFMSAG 48533
48727 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 48846

CYP4F-se12[6:8] human = CYP4F44P
           NT_008251.13|Hs8_8408 Homo sapiens chromosome 8 genomic contig
           Length = 5847381 
           chr8P11.1 43132635-43132941 + STRAND BUILD 33
Query: 1       PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
               PS+YIAT+ ELSALI+*  QQI L  DFLYY   EG CFCRAC +VHNF
Sbjct: 5439042 PSDYIATILELSALIM*RQQQIFLHRDFLYYVTAEGWCFCRACVVVHNF 5439188

Query: 50      DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
               DTIILEQ CTLTSQGV++FLK  ATFKT DF D LVL K
Sbjct: 5439190 DTIILEQHCTLTSQGVNNFLKVTATFKTLDFIDVLVLDK 5439306

Query: 111     GYDSTATGLY*IL 123
               GYDSTA+GL+ +L
Sbjct: 5439892 GYDSTASGLFWVL 5439930

Query: 131     GVMPSCGARVLRDHNPEDIEW 151
               GV+P+ GA VLRDH+PEDIEW
Sbjct: 5439959 GVLPALGAGVLRDHSPEDIEW 5440021

CYP4F-se13[6:8] human = CYP4F45P (name conflict with macaque) 
            AC018949 62% to 4F3 pseudogene
            found in two places 100% match
            CYP4F-se1[6:8]  chr9p11.2 43742181-43742487 (4F25P) + strand build 33
            CYP4F-se13[6:8] chr9q13   63753376-63753682 (4F45P) + strand build 33
            NT_078070.1|Hs9_78139 Homo sapiens chromosome 9 genomic contig
            Length = 423701 
Query: 1     PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
             PSEYIAT+ ELSALIV* HQQICLC DFLYY  PEG CFCRACDLVHNF
Sbjct: 34719 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 34865

Query: 50    DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
             DTIILE+ CTLTSQGV DFL  KATFK +DFSDA VL K
Sbjct: 34867 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 34983

Query: 111   GYDSTATGLY*ILCNLRRHP 130
             GYDSTA+GLY IL  LRRHP
Sbjct: 35569 GYDSTASGLYWILVPLRRHP 35628

Query: 131   GVMPSCGARVLRDHNPEDIEW 151
             GV+P  GARVLRD N EDIEW
Sbjct: 35636 GVLPPRGARVLRDGNSEDIEW 35698

CYP4F-se14[6:8] human = CYP4F59P
             Chr9:43030439-43031461 (-) strand
             
CYP4F-se15[6:7:8] human = CYP4F60P
             Chr9:44019570-44020591 (-) strand
             
CYP4F-se16[6:7:8] human = CYP4F61P
             Chr9:66367007-66368028 (-) strand
             
CYP4FA1    see bottom of Cyp4 family entries

4G Subfamily

Cyp4g1      Drosophila melanogaster
            no accession number
            Waters,L.C. personal communication (1993)
            Note: called P450-A1 starts at amino acid 192 and goes to 
            the end.  

Cyp4g1      Drosophila melanogaster
            GenEMBL U34328(385bp)
            Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
            ffrench-Constant,R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genet. 251, 290-297 (1996)

Cyp4g1      Drosophila melanogaster
            GenEMBL AL009188 comp (26402-24747) region genomic

Cyp4g1      Drosophila melanogaster
            GenEMBL AC020093 comp(33262-34932) no introns

Cyp4g1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4G2v1    Musca domestica (house fly)
            Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh, 
            R. H. ffrench-Constant and R. Feyereisen.
            1996. Cytochrome P450 gene clusters in Drosophila
            melanogaster. Mol. Gen. Genetics 251: 290-297.
            Dta1
            corrected from error, previously listed as 4G6

CYP4G2v1    Musca domestica (house fly)
            no accession number (559 amino acids)
            Claus Tittiger and Gary Blomquist
            submitted to nomenclature committee 1/5/98

CYP4G2v1    Musca domestica (house fly)
            No accession number
            Nannan Liu
            submitted to nomenclature committee 7/20/06
            clone #20-3
            71% to Cyp4g1 65% to 4g13v2
            1 aa diff to 4G2v1 Blomquist and Tittiger 1/5/98

CYP4G2v2    Musca domestica (house fly)
            No accession number
            Nannan Liu
            submitted to nomenclature committee 7/20/06
            clone #20-1
            65% to 4g1 60% to 4g13
            99% (4 aa diffs) to 4G2v1 plus 4 frameshifts

CYP4G3      Musca domestica (house fly)
            Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh, 
            R. H. ffrench-Constant and R. Feyereisen. 1996. 
            Cytochrome P450 gene clusters in Drosophila melanogaster. 
            Mol. Gen. Genetics 251: 290-297.
            Dt6-139
            corrected from error, previously listed as 4G5

CYP4G4      Manduca sexta (tobacco hornworm)
            GenEMBL AY635178.1
            Snyder,M.J., Guzov,V.M., Stevens,J.L. and Feyereisen,R.
            A CYP4G-like transcript expressed in the prothoracic glands of
            Manduca sexta
            Unpublished

CYP4G4     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4G5      Heliothis virescens(tobacco budworm)
            no accession number (382bp)
            Richard ffrench-Constant
            submitted to nomenclature committee
            corrected from error, previously listed as 4G2
            Hv-13a

CYP4G6      Heliothis virescens(tobacco budworm)
            no accession number (386bp)
            Richard ffrench-Constant
            submitted to nomenclature committee
            corrected from error, previously listed as 4G3
            Hv-1

CYP4G7     Tribolium castaneum (red flour beetle)
           GenEMBL AF265300
           Jeff Stuart
           R39
           submitted to nomenclature committee
           TAAASSFFICILGVYPEIQEKVYQELRDIFQDSDRPITFNDTLQ
           MKYLERVLLETLRMYPPVPIITRVINEEVKLASGDYTLPVGTTVGIGQFLVHRNPKYF
           PNPDKFDPDNFLPERCQQRHYYSY

CYP4G7     Tribolium castaneum (red flour beetle)
           GenEMBL XP_975951
MVVVEESLNHSLNLGNSVLISLGVVAVILAVYHFWLQSLRYTKLGNKIPGYDPLPIIGNAHMVMNKNPTQ
VMELALRVASEKGSVVRFWFGSKLGVALLDPRDIELILGSNVHLEKSSEYRFFEPWLGDGLLISKGDKWR
SHRKMIAPTFHQSILKTFVPVFNKNAMDLVEQLRNEALDQICDVHDYLSGATVDVLLETVMGVKKTKEAR
TSYKYAKAVMDMCTILHFRHVKLWLRSDWIFSFTKLFKEQTSLLRIIHNLTDRVIKQKKKETEEENLKIK
NEQTFNFGSGLRDDLDENDENLGEKKRLAFLDFMVEASQTEGNKLNDEEIREEVNTIMFEGHDTTAAASS
FFICILGVYPEIQEKVYQELRDIFQDSDRPITFNDTLQMKYLERVLLETLRMYPPVPIITRVINEEVKLA
SGDYTLPVGTTVGIGQFLVHRNPKYFPNPDKFDPDNFLPERCQQRHYYSFIPFSAGPRSCVGRKYAMLKL
KILLASIVRNFKIKSVVKEKDFQLQADIILKRADGFRVILTSRT

CYP4G8v1   Helicoverpa armigera (Australian cotton bollworm) 
           GenEMBL U86002
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp24
           submitted to nomenclature committee

CYP4G8v1   Helicoverpa armigera (cotton bollworm)
           No accession number
           Vladimir Grubor
           submitted to nomenclature committee Dec. 30, 2003
           86% to 4G15 C-term frag. 98 aa seq #3 HaCypZ006a-v2Pep
           note old 4G8, 4G9 and 4G10 were all PCR fragments
           the Heme region AGPRNCIGQ is the same in all 3
           and it may be a primer used for the PCR that was not
           trimmed. only 1 aa diff outside the primer region

CYP4G8v1   Helicoverpa armigera (cotton bollworm)
           No accession number
           Heiko Vogel 
           submitted to nomenclature committee Feb. 6, 2008
           Contig_179 has 3 aa diffs to HAH002281 
           74% to CYP4G36 Aedes
           100% to partial CYP4G8 HaCypZ006a-v2Pep 
           HAH002281 has 3 aa diffs to Contig_179

CYP4G8v2   Helicoverpa armigera (Australian cotton bollworm) 
           no accesssion number
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp443
           submitted to nomenclature committee

CYP4G8v3   Helicoverpa armigera (Australian cotton bollworm) 
           no accesssion number
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp477g
           submitted to nomenclature committee

CYP4G8v4   Helicoverpa armigera (Australian cotton bollworm) 
           no accesssion number
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp73g
           submitted to nomenclature committee

CYP4G9     Helicoverpa armigera (Australian cotton bollworm) 
           GenEMBL U86003
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp60
           submitted to nomenclature committee

CYP4G9      Helicoverpa armigera (cotton bollworm)
            No accession number
            Vladimir Grubor
            submitted to nomenclature committee Dec. 30, 2003
            78% to 4G17 C-term frag. 261 aa seq #5 HaCypZ008a-v1Pep
            note old 4G8, 4G9 and 4G10 were all PCR fragments
            the Heme region AGPRNCIGQ is the same in all 3
            and it may be a primer used for the PCR that was not
            trimmed. only 1 aa diff outside the primer region.

CYP4G9     Helicoverpa armigera (cotton bollworm)
           No accession number
           Heiko Vogel 
           submitted to nomenclature committee Feb. 6, 2008
           correct version 60% to CYP4G17, 3 aa diffs to CYP4G9 
           Contig_165 is missassembled, 1 aa diff to CYP4G9 of Grubor
           Contig_166 1 aa diff to Contig_165 1 aa diff to CYP4G9 of Grubor

CYP4G10    Helicoverpa armigera (Australian cotton bollworm) 
           GenEMBL U86004
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp5g
           submitted to nomenclature committee

CYP4G10X    Helicoverpa armigera (cotton bollworm)
            No accession number
            Vladimir Grubor
            submitted to nomenclature committee Dec. 30, 2003
            78% to 4G17 C-term frag. 100 aa seq #13
            note old 4G8, 4G9 and 4G10 were all PCR fragments
            the Heme region AGPRNCIGQ is the same in all 3
            and it may be a primer used for the PCR that was not
            trimmed. only 3 aa diffs outside the primer region to 4G10
            revised longer sequence is diffferent from 4G10 renamed CYP4G26

CYP4G11    Apis cerana cerana (Asian Honeybee)
           No accession number
           Han Li
           Submitted to nomenclature committee July 14, 2013
           96% identical to CYP4G11 Apis mellifera (honey bee)

CYP4G11    Apis mellifera (honey bee)
           GenEMBL AF207948
           S. Tares, J.B. BergŽ and M. Amichot.           
           Cloning and expression of cytochrome P450 genes belonging to the 
           CYP4 family and to a novel family, CYP48, in two hymenopteran insects, 
           Trichogramma cacĪciae and Apis mellifera  
           BBRC 268, 677-682 (2000) 
           clone 18Am

CYP4G11v2  Apis mellifera mellifera (honeybee)
           No accession number 
           S. Tares, J.B. BergŽ and M. Amichot.           
           Cloning and expression of cytochrome P450 genes belonging to the 
           CYP4 family and to a novel family, CYP48, in two hymenopteran insects, 
           Trichogramma cacĪciae and Apis mellifera  
           BBRC 268, 677-682 (2000) 
           clone 9Am only 2 amino acid differences, one in EXXR motif, possible PCR 
           errors

CYP4G12    Trichogramma cacĪciae  (a parasitoid wasp)
           GenEMBL AF207949
           S. Tares, J.B. BergŽ and M. Amichot.           
           Cloning and expression of cytochrome P450 genes belonging to the 
           CYP4 family and to a novel family, CYP48, in two hymenopteran insects, 
           Trichogramma cacĪciae and Apis mellifera  
           BBRC 268, 677-682 (2000) 
           clone 3Tc 76% identical to CYP4G8
           clone 6Tc is identical to 3Tc in the coding region but not in a short 
           intron this probably represents a recent gene duplication rather than an 
           allele

CYP4G13     Musca domestica (house fly)
            no accession number
            Xiaohua Shen, Gary Blomquist
            68% identical to 4G1 full length, but different from 4G2 fragment (75%) 
            and 4G3 fragment (71%)
            submitted to nomenclature committee 10/9/98

CYP4G13v2   Musca domestica (house fly)
            GenEMBL AF355145.1
            Nannan Liu
            98% identical to 4G13, may be same gene with some errors between the 
            two
            submitted to nomenclature committee 7/29/99

CYP4G14     Tribolium castaneum (red flour beetle)
            GenEMBL AF263514
            Jeff Stuart
            S19
            submitted to nomenclature committee
            TAAGSSFFLSMMGVHQDIQDKVVQELYDIFGDSDRPATFADTLE
            MKYLERCLMETLRMFPPVPIIARQLNQDLKLASGDYTVPAGCTVVIGTFKVHRLEEYY
            PNPDKFDPDNFLPERTANRHYYSFI

CYP4G14    Tribolium castaneum (red flour beetle)
           GenEMBL XP_973423, AF263514, AAJJ01000136
           82% to 4G29 (shortened N-term in gene model)
MSTTVPTPDISTPSGILSASNVFYFLLIPALLLWYAYWRISKRHMLELAAKIPGPPGLPILGNALDLVGKPH  99617
99569  VFSHVYQKSFEYKKVVKMWAGPKLLVFLTDPSDIELILSSYVHIDKSSEYRFFKPWLGDG  99390
99389  LLISTGQKWKAHRKLIAPTFHLNVLKSFIDLFNANSRDVIRKLQKEIGKEFDCHDYMSEATVEMLL  99192
ETAMGVSKKTQDQSGYDYAMAVMKMCDILHLRHTKFWLRPDIIFNQTKYAEYQKSLINTIHSLTRKV
IKRKRADFDKGIRGSTAEVPPELQTKNYDKTESKTVVEGLSYGQSAGLKDDLDVDDNDIGEKKRMAFLDL
MIEASQNGVVINDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGVHQDIQDKVVQELYDIFGDSDRPATFA
DTLEMKYLERCLMETLRMFPPVPIIARQLNQDLKLASGDYTVPAGCTVVIGTFKVHRLEEYYPNPDKFDP
DNFLPERTANRHYYSFIPFSAGPRSCVGRKYAMLKLKILLSTILRNYRIYSDLKEKDFQLQGDIILKRAE
GFKVRLEPRKMAKA

Cyp4g15     Drosophila melanogaster
            GenEMBL AF159624
            M. Ma•bche, D. Bšcking, S. Aragon and C. Dauphin-Villemant.
            submitted to nomenclature committee 6/15/99
            ESTs AI134510, AI388987, AI403684

Cyp4g15     Drosophila melanogaster
            GenEMBL AC013897 comp(8972-10574 and 5306-6643) two pieces

Cyp4g15     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4G16     Anopheles gambiae
            GenEMBL AY062189
            Hilary Ranson
            Submitted to nomenclature committee 8/9/99
            clone name P450A
            79% identical to 4G8

CYP4G16     Anopheles gambiae (malaria mosquito)
            GenEMBL AY062189
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs1x5

CYP4G17     Anopheles gambiae
            GenEMBL AY062200
            Hilary Ranson
            Submitted to nomenclature committee 8/9/99
            clone name P450L
            69% identical to 4G9

CYP4G17     Anopheles gambiae (malaria mosquito)
            GenEMBL AY062200
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs1x3

CYP4G18     Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
            GenEMBL AF243507
            Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
            Insecticide Resistance Associated Cytochrome P450 Gene Fragments
            from D. v. virgifera
            Unpublished
            DvP450-2 

CYP4G19     Blattella germanica (German cockroach)
            GenEMBL AY176056.1 
            Nannan Liu
            Submitted to nomenclature committee 9/24/02
            About 65% identical to Cyp4g15

CYP4G20     Mamestra brassicae (moth)
            GenEMBL AY390259
            Martine Maibeche 
            73% to 4G16 
            submitted to nomenclature committee Sept. 12, 2003

CYP4G21    Anopheles funestus 
           GenEMBL AY648704
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 4 
           94% to 4G17 probable ortholog of 4G17

CYP4G22  Bombyx mori (silkworm)
         AV404689 prothoracic gland EST spans two contigs
         AV405174 prothoracic gland EST
         AV404871 prothoracic gland EST
         BP183989 P5PG cDNA clone
         BP182770 cDNA clone NRPG1026
         BP182055 NRPG cDNA clone
         BP183011 cDNA clone NRPG1327
         BP183771 P5PG cDNA clone
         AU004478 EST
         BP183321 NRPG cDNA clone
         BAAB01118673.1 BAAB01085960.1 84% to 4G20
         64% to 4G19
         Temp name 4Gxx
MSYTNAENVVPTSTFSAINLFYVLLVPAVILWYAYWRMSRRRLYELADKLNGPPGLPLLGNALEFVGGSA ()
DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLIST (1?)
GQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFDCHDYMSECTVEILL (1)
 234 ETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 431 (0)
 988 VIKRKKEEFASGKKPSNLNETATTSEPSTGKLTSVEGLSFGQSSGLKDDLDVDDDVGQK 1164
1165 KRLAFLDLLLESSQSGVAISDEEIKEQVDTIMFE 1266 ()
1340 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMET 1516
1517 LRLYPPVPIIARQVNQEITL 1576 ()
1680 SNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCV 1862 (1)
1960 GRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPRKRMAKA* 2136

CYP4G23  Bombyx mori (silkworm)
         CK508129 rswdd0_001928.y1 swd cDNA
         CK505752 rswcc0_009305.y1 swc cDNA
         AV401408 BP122820 BP123076 BP183420 CK509955 CK505752 CK505553
         BAAB01050777.1 BAAB01096227.1 BAAB01156775.1 BAAB01003438.1
         BAAB01073763.1 BAAB01110168.1 BAAB01050777.1
         58% to 4G19 59% to CYP4G22
         Temp name 4Gyy
MTSLVDETEGYHVNSRVIFYPLLGLTTAIWILYRWQQNSHMHKLAELLPGPASIPIFGNALTLMRKNPHE ()
LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISS (1?)
GPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGTTVDILL ()
ETAMGISRKTQDESGFDYAMAVMK ()
MCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK ()
VIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDV ()
GEKKRLAFWDLMIESSQNGTNKISDHEIKEEVDTIMFE ()
GHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYL
ERVILESLRLYPPVPVIARKLNRDVTI ()
STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1)
GRKYALLKLKILLSTILRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPRKRVPTNVAR*

CYP4G24  Bombyx mori (silkworm)
         BAAB01149226.1 BAAB01135847.1 BAAB01073803.1 BAAB01199362.1
         FIRST TWO EXONS ARE JOINED WITHOUT OVERLAPPING EVIDENCE
         BUT THEY ARE THE ONLY OTHER 4G N-TERM SEQUENCES WITHOUT A PARTNER
         71% TO CYP4G23
         Temp name CYP4Gzz
MSSLLNYNFEFDVPPIFHTLLLAIMIMWM
LHRWQQSSRLFRLGNKLPGPMALPLVGNSLLILGKKAEGW = BAAB01031491.1
VKYALDYSEKYG
TVVRAWAGPKLVVFLTDANDVEVILNSQIHIDKSPEYRFFKPWLGEGLLISSG = BAAB01016193.1
XKWRSHRKMIAPTFHINILKSFMGVFNENSKSVVKKLRSEVGKTFDVHDYMSCVTVDILL
ETAMGITKTTQDAASFDYAMAVMK
MCNIIHQRHYKVWLHFDAIFKLTSLFKKQRELLKTIHGLTNK (0)
VIKKKKFMYLQNKEKGIIPPTIEELTKIKDTNDSIMEDSAKTLSDTVFKGYRDDLDFNDEQDV ()
GEKKRLAFLDLMIESAQNHTCNISDHEIKEEVDTIMFE ()
GHDTTAAGSSFVLCLLGIHQEIQSKV
YDELFEIFGDSDRLVTFADTLQMKYLERVILESLRLYPPVPAIARKLTRDVQI ()
VTNNYIIPAGSTVVIGTFKIHRDPKYHKNPNVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1)
GRKYALLKLKVLLSTILRNYKTTSEISEDQFVLQADIILKRYDGFKIRIEPRNKNHSNTV*

CYP4G25    Antheraea yamamai (Japanese oak silkmoth)
           GenEMBL AB196795 
           Yang,P., Onodera,C., Abe,S., Saito,N., Tanaka,H. and Suzuki,K.
           Molecular cloning and nucleotide sequence of a cytochrome P450 cDNA
           from the wild silkmoth, Antheraea yamamai.
           Unpublished
           87% to the silkworm seq temporarily named CYP4Gxx (see silkworm seqs)

CYP4G25    Antheraea pernyi (Chinese oak moth, Chinese Tussah moth)
           GU205081 not released as of Nov. 24, 2009
           Qiuning Liu
           submitted to nomenclature committee Nov. 23, 2009
           97% to CYP4G25 Antheraea yamamai

CYP4G26     Helicoverpa armigera (cotton bollworm)
            No accession number
            David G. Heckel 
            submitted to nomenclature committee Feb. 21, 2005
            HaCypZ013a-v2Pep
            Previously assigned to CYP4G10, but the longer sequence is not 4G10
            478aa almost complete, 79% to 4Gyy silkworm 80% to 4G10

CYP4G26    Helicoverpa armigera (cotton bollworm)
           No accession number
           Heiko Vogel 
           submitted to nomenclature committee Feb. 6, 2008
           Contig_174 has 1 aa diff to HAH004055 61% to CYP4G17, 
           6 aa diffs to CYP4G26 HaCypZ013a-v2Pep partial seq
           HAH004055 has 1 aa diff to Contig_174
           Contig_215 100% to HAH004055 C-term, 2 aa diffs to CYP4G26 of Heckel

CYP4G27     Ips paraconfusus (California fivespined ips, bark beetle)
            GenEMBL DQ471883
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            65% to 4G22, full length

CYP4G28     Papilio polyxenes (black swallowtail butterfly)
            No accession number
            Zhimou Wen, Mary Schuler, May Berebaum
            Submitted to nomenclature committee June 17, 2005
            85% to 4G22 of silkworm

CYP4G29     Leptinotarsa decemlineata (Colorado potato beetle)
            GenEMBL DQ117464
            Jianhua Zhang
            Submitted to nomenclature committee June 29, 2005
            65% to 4G15, 74% to 4G28

CYP4G29     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4G294419
            65 amino acids from heme to end

CYP4G30     Spodoptera litura (common cutworm)
            GenEMBL DQ350811
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name RAG3 81% to 4G23

CYP4G31     Spodoptera litura (common cutworm)
            GenEMBL DQ350813
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SC2: 80% to 4G23

CYP4G32     Spodoptera litura (common cutworm)
            GenEMBL DQ350812
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SD2: 78% to 4G23

CYP4G33     Chironomus tentans (aquatic midge)
            GenEMBL AY880065
            Londono,D.K., Siegfried,B.D. and Sarath,G.
            Induction of cytochrome P450 family 4 by atrazine in Chironomus
            tentans
            Unpublished
            62% to 4G17

CYP4G34     Leptinotarsa decemlineata (Colorado potato beetle)
            GenEMBL DQ631644
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4G2535138
            61 amino acids from heme to end
            67% to 4G17, 62% to 4G7, 60% to 4G29

CYP4G34    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Shi Xiaoqin 
           Submitted to nomenclature committee Dec. 10, 2010 
           CYP4 clan
           Clone name seq 5
           100% to CYP4G34 C-term

CYP4G35    Aedes aegypti (yellow fever mosquito)

CYP4G35    Culex pipiens

CYP4G36    Aedes aegypti (yellow fever mosquito)

CYP4G36    Culex pipiens

CYP4G37     Spodoptera exigua Hubner (beet armyworm)
            GenEMBL EF113593
            Mo Jianchu
            Submitted to nomenclature committee Oct. 30, 2006
            98% to 4G31
            151 aa fragment

CYP4G38     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-9, 70% to 4G29 Leptinotarsa decemlineata (Colorado potato beetle), 
            68% to 4G28 Papilio polyxenes
            Pediculus genome site

CYP4G39     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-1, 54% to 4g15 Drosophila, 56% to 4G16 Anopheles, 
            56% to 4G11 Apis, 57% to 4G29 Leptinotarsa decemlineata
            Pediculus genome site

CYP4G40     Apocrypta bakeri (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 17, 2007
            88% to 4G11 Apis

CYP4G41     Ceratosolen solmsi martchali (Hymenoptera) fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 17, 2007
            84% to 4G11 Apis

CYP4G42     Philotrypesis sp (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 17, 2007
            85% to 4G11 Apis

CYP4G43    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4G44    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4G45X   Bombyx mori (silkworm)
           This name does not match any known silkworm sequence
           Is is probably an error

CYP4G46    Lucilia cuprina (Australian blowfly)
           No accession number 
           Zhenzhong Chen
           Submitted to nomenclature committee Dec. 18, 2007
           clone name Luce0090J16 (531 aa, missing N-term)
           82% identical to Drosoph. Cyp4g15

CYP4G47    Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_c636 
           86% to 4G28 Papilio polyxenes

CYP4G48    Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_2363 
           74% to 4G23 Bombyx mori

CYP4G49    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4G50    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4G51    Acyrthosiphon pisum (pea aphid)
           LOC100164072 
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           64% to CYP4G16
           CYP4 clan
MVTNVQGVNPLFALSAFNLFFYLLTPAIVLWYIYFRMSRKQLYDLASKIPGSEGLPLLGNALDFMQDPHTIFEKIYERSFEFEKNSPIKMWIGPRLLVFLTDPRDVEVILSSNVYIDKSPEYRLFEPWLGNGLLISTGDKWRAHRKLIAPTFHLNVLKSFVTLFNVNSRDTVSKLRKMGSSTFDIHDFMSECTVEILLETAMGVSKKTQKKSGFEYAAAVMKMCDILHMRHTNLWLKPDFIFNFTKYAKEQVGLLDLIHGLTNNVLAKKKEEFLKKKSLMKEVSDIPAASEEIVETSSTLEVEEVPYGNSFGQSAGLKDDLDVEDDGIGEKKRVAFLDLLIECSENGVVLSDEEVREQVDTIMFEGHDTTAAGSSFFLCLMGAHQDVQQKVVDELYSIFGDSDRPVTFQDTLQMKYMERCIMETLRMYPPVPIISRQIKEKVKLGEDITLPVGATIVIATFKIHRNEDVFPNPEVFNPDNFLPEKSASRHYYAYVPFSAGPRSCVGRKYAMLKLKIILSTILRNFKINSNLTEKDWKLQADIILKRTDGFKLSLEPRKSLAKTAA 

CYP4G52    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig04379 540aa 
           57% TO CYP4G36 Aedes, in the CYP4 clan

CYP4G53    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig8045 523aa 
           62% TO CYP4G14 Tribiolium, in the CYP4 clan

CYP4G54    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig11924 541aa 
           55% TO CYP4G14 Tribolium, in the CYP4 clan

CYP4G55     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            82% to CYP4G27 Ips paraconfusus (California fivespined ips, bark beetle)
            clone name DPO0818_D23

CYP4G55v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH4-1
            95% to CYP4G55 Dendroctonus ponderosae (probable ortholog), 
            98% to CYP4G55v2

CYP4G55v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH4-2
            95% to CYP4G55 Dendroctonus ponderosae (probable ortholog), 
            98% to CYP4G55v1

CYP4G55v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4E-1
            100% to CYP4G55v4
            99% to CYP4G55v2 
            96% to CYP4G55 DPO0818_D23

CYP4G55v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4E-2
            100% to CYP4G55v3
            99% to CYP4G55v2 
            96% to CYP4G55 DPO0818_D23

CYP4G56     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            56% to CYP4G44 Nasonia vitripennis (jewel wasp)
            clone name DPO1118_C02

CYP4G56v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH5-1
            96% to CYP4G56 Dendroctonus ponderosae (probable ortholog), 
            100% to CYP4G56v2 at thje amino acid sequence level

CYP4G56v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH5-2
            96% to CYP4G56 Dendroctonus ponderosae (probable ortholog), 
            100% to CYP4G56v1 at thje amino acid sequence level

CYP4G56v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4C-1
            97% to CYP4G56 DPO1118_C02
            97% to CYP4G56v1 
            small insertion compared to CYP4G56v4

CYP4G56v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4C-2
            100% to CYP4G56v1 
            97% to CYP4G56v3

CYP4G57    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-13
           59% to CYP4G7 Tribolium castaneum (aa 64-261)
           68% to CYP4G56

CYP4G58    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-4
           52% to CYP4G47 Zygaena filipendulae (aa 116-169) C-helix region
           52% to CYP4G28 Papilio polyxenes

CYP4G59    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4G60    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4G61    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4G62     Locusta migratoria manilensis
            No accession number
            Rongrong Yu
            Submitted to nomenclature committee Dec. 12, 2010
            64% to CYP4G35 Aedes aegypti

CYP4G63    Linepithema humile (argentine ant)
           No accession number

CYP4G64    Linepithema humile (argentine ant)
           No accession number

CYP4G65    Linepithema humile (argentine ant)
           No accession number

CYP4G66    Linepithema humile (argentine ant)
           No accession number

CYP4G67    Linepithema humile (ant)
           No accession number

CYP4G68    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           Formerly CYP4G63 but changed due to name conflict
           77% to CYP4G60 Trialeurodes vaporariorum (whitefly)

CYP4G69    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           Formerly CYP4G64 but changed due to name conflict
           66% to CYP4G60 Trialeurodes vaporariorum (whitefly)

CYP4G70    Diaphorina citri Kuwayama (Asian citrus psyllid)
           No accession number 
           Siddharth Tiwari
           Submitted to nomenclature committee April 7, 2011
           78% to CYP4G43 Nasonia

CYP4G71     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            90% to CYP4G4 Manduca sexta

CYP4G72    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           90% to CYP4G65 Linepithema humile
           Formerly CYP4G71, but name conflict 

CYP4G73     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            64% to CYP4G71 Heliconius melpomene

CYP4G74     Spodoptera frugiperda (a moth)
            No accession number
            Rene Feyereisen
            Submitted to nomenclature committee Aug. 1, 2011
            88% to CYP4G26 Heliothis virescens

CYP4G75     Spodoptera frugiperda (a moth)
            No accession number
            Rene Feyereisen
            Submitted to nomenclature committee Aug. 1, 2011
            91% to CYP4G8 Helicoverpa armigera

CYP4G75     Spodoptera littoralis
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            98% to CYP4G75 Spodoptera frugiperda (ortholog)

CYP4G76    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           63% to CYP4G29 Leptinotarsa decemlineata, 
           64% to CYP4G4 Manduca sexta
           N-term half

CYP4G77    Plutella xylostella 
           Gene number CCG008026.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           87% to CYP4G8 Helicoverpa armigera
           complete

CYP4G78    Plutella xylostella 
           Gene number CCG007099.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           79% to CYP4G49   Manduca sexta
           complete

CYP4G79    Harmonia axyridis (ladybug)
   
CYP4G80    Lucilia sericata (sheep blowfly)

CYP4G81    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP4G82    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012


4H Subfamily

CYP4H1      Anopheles albimanus (mosquito)
            GenEMBL L38682 (382bp) PIR PC2261 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H2      Anopheles albimanus (mosquito)
            GenEMBL L38683 (382bp) PIR PC2262 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H3      Anopheles albimanus (mosquito)
            GenEMBL L38684 (382bp) PIR PC2263 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H4      Anopheles albimanus (mosquito)
            GenEMBL L38685 (382bp) PIR PC2264 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H5      Anopheles albimanus (mosquito)
            GenEMBL L38686 (382bp) PIR PC2265 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H6      Anopheles albimanus (mosquito)
            GenEMBL L38687 (452bp) PIR PC2266 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H7      Anopheles albimanus (mosquito)
            GenEMBL L38688 (382bp) PIR PC2267 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H8      Anopheles albimanus (mosquito)
            GenEMBL L38689 (461bp) PIR PC2268 (127 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H9      Anopheles albimanus (mosquito)
            GenEMBL L38690 (406bp) PIR PC2269 (135 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4H10X   Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           R26
           submitted to nomenclature committee
           note this short sequence has been renamed as CYP4BR1
           after the full sequence became known.

CYP4H11X   Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           R18
           submitted to nomenclature committee
           note this short sequence has been renamed as CYP4BN6
           after the full sequence became known.

CYP4H12v1  Culex pipiens pallens (mosquito)
           GenEMBL AF157091
           Zhu Changliang, Dept. of Parasitology, Nanjing University
           submitted to nomenclature committee 5/20/99
           PCR C-terminal fragment 125 amino acids
           clone name NYDR1 73% identical to 4H7 
           this sequence has three frameshifts and some poor quality sequence at    
           the 5 prime end
MFEGHDTTTSGIAFTILQLAKHQHLRQKVYDEIVAILGQGGSKT
TPLTYNNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYF
VHRNPDVYPDPERFDPERFAEGSEQQQRRGPYDYIPFWAGPRNCIGH

CYP4H12v2  Culex pipiens
           AF191731
           Changliang Zhu
           Clone NYDR19 PCR fragment 100% aa identical to NYDR18
           98% identical to 4H12v1
           1 aa diff to 4H12v4
           Submitted to nomenclature committee 9/30/99
           This seq was accidentally named CYP4H23v1
TTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKT
TPLTYNNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYI
VHRNPDVYPDPERFDPERFAEGSEQQQRRGPYDYI

CYP4H12v4  Culex pipiens pallens
           CB074950.1
           NJS1618(7) 497bp, NJ007 in Genbank entry
           96% to CYP4H12v5, 6 diffs, 73% to 4H24 
           99% to 4H12v3 97% to 4H12v1
NSLVIEVDTFMFEGHDTTTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKTTPLTYN
NLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYIVHRNPDVY
PDPERFDPERFAEGSEQQQRREPYDYIPFSAGPRNCIGQNRIPAA

CYP4H12v5  Culex pipiens pallens
           CB074949.1
           NJS1618(9) 496bp, NJ006 in Genbank entry
           96% to NJS1618(7) 6 diffs 71% to 4H24 96% to 4H12v3 95% to 4H12v1
GRGNSIEVDTFMFEGHDTTTSGIALTILQLAKHQDLQQKVYDEIVAILGQEGSKTTPLTY
NNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGRDVTVPIYIVHRNPDV
YPDPERFDPERFAEGSEQQQRRGPYDYIPFTAGPRNCIGQNH

CYP4H13    Culex pipiens pallens (mosquito)
           GenEMBL AF160259
           Zhu Changliang, Dept. of Parasitology, Nanjing University
           submitted to nomenclature committee 5/20/99
           PCR C-terminal fragment 151 amino acids
           clone name NYDR3 74% identical to 4H5 
           This sequence has a retained intron
EVDTFMFEGHDTTTSRISFTIWHLAKYQDVQQRLYEEIDRILGE
DKKHAELTNLKVQESEYLDMVVKESLRLIPPVPIIGRCLLEDMEM 
DGVTIPAGTNISIKICNIHTNPKIRPNPEKFDPERFSKTNEDKRGPYDYIPFW
AGPRNCIG

CYP4H14    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450P
           94% identical to 4H8

CYP4H14     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPc2r1

CYP4H14     Anopheles funestus
            No accession number 
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            Submitted to nomenclature committee 1/5/05
            92% to 4H14 A. gambiae probable ortholog, 58% to 4H24
            also 92% to 4H8 A. albimanus, probable ortholog

CYP4H15    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450B
           77% identical to 4H3

CYP4H15     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPc2r2

CYP4H15v2  Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450Y
           one amino acid difference with 4H15, DNA is 95% identical

CYP4H16    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450C
           78% identical to 4H6

CYP4H16     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPn3r1

CYP4H17    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450D
           83% identical to 4H16

CYP4H17     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPn3r3

CYP4H18    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450G
           77% identical to 4H16

CYP4H18     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPn3r2

CYP4H19    Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450K
           78% identical to 4H7

CYP4H19     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPa1x1

CYP4H20X   Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450O
           50% identical to 4H5, 4H7 
           note the 4H subfamily might really be considered two differernt 
           subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.  
           4H20 falls between these.
           Renamed CYP4D22

CYP4H21v1  Culex pipiens
           AF208660
           Changliang Zhu
           Clone NYDR15 PCR fragment 79% identical to 4H13
           Submitted to nomenclature committee 9/30/99
TTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNVKI
QEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMDGTTIPAGTQINIKIYNIHRNPKIW
PDPERFDPDRFSKTNEDKRGPYDFI

CYP4H21v2  Culex pipiens pallens
           CB074948.1
           NJS1618(10) 487bp, NJ005 in Genbank entry
           98% to CYP4H21v3, 3 diffs, 72% to 4H18, 97% to 4H21
GRGNSIEVDTFMFEGHDTTTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNV
KIQEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMNGTTIPAGTQINIKIYNIHRNPKIW
PDPERFDPDRFSKTNEDRRGPYDYIPFTAGPRNCIGQNH

CYP4H21v3  Culex pipiens pallens
           CB270837.1
           NJS1618(11) 487bp, NJ009 in Genbank entry
           98% to CYP4H21v2, 3 diffs, 71% to 4H18, 96% to 4H21
GRGNSIEVDTFMFEGHDTTTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNV
KIQEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMNGTTIPAGTQINTKIYDIHRNPKIW
PDPERFDPDRFSKTNEDKRGPYDYIPFTAGPRNCIGQNH

CYP4H22v1  Culex pipiens
           GenEMBL AF190782
           Changliang Zhu
           Clone NYDR7 PCR fragment 96% identical to 4H22v2, 57% to 4H3
           Submitted to nomenclature committee 9/30/99
TTSCISFAAYHIARNTAVQHKLYDEMVQVLGPDFKNAQLTYSNL
QELKYLEMTIKEVLRIHPSVPVIGHKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVF
PEPTRFDPERFNEENSSKRHPYAYV

CYP4H22v2  Culex pipiens
           AF190784
           Changliang Zhu
           Clone NYDR9 PCR fragment 96% identical to 4H22v1
           Submitted to nomenclature committee 9/30/99
TTSCISFAAYHIARNPAVQQKLYDEMVQVLGPDFKNAQLTYSNL
QELKYLEMTIKEVLRIHPSVPVIGRKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVF
PEPTRFDPERFNEESSSKRHPYAYV

CYP4H22v3  Culex pipiens pallens
           CB074946.1
           NJS1618(3) 483bp, NJ003 in Genbank entry
           56% to CYP4H12v4, 64% to 4H15, 96% to 4H22v2
NSLVIEVDTFMFEGHDTTTSCISFAAYHIARNPAVQQKLYDKMVQVLGPDFENAQLTYSN
LQELKYLEMTIKEVLRIHPSVPVIGRKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVFP
EPTRFDPERFNEENSSKRHPYASVPFTAGPRNCIGQNRIPAA

CYP4H23v1X  Culex pipiens
           AF191731
           Changliang Zhu
           Clone NYDR18 PCR fragment 100% amino acid identical to 4H23v2
           Submitted to nomenclature committee 9/30/99
           Note: these sequences are 50% to 4D14 and 47% to 4H7,
           But they sort to the 4H cluster on a tree.
           1 aa div to 4h12v4, 2 aa diffs to 4H12v1
           This seq is 100% identical to CYP4H12v2 not a 4H23 seq
TTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKTTPLTYNN
LNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYIVHRNPDV
YPDPERFDPERFAEGSEQQQRRGPYDYI

CYP4H23v2  Culex pipiens
           AF190787
           Changliang Zhu
           Clone NYDR12 PCR fragment 100% amino acid identical to 4H23v1
           Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNTSKQVSLAGLTVPPNTNISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV

CYP4H23v3  Culex pipiens
           AF191729
           Changliang Zhu
           Clone NYDR17 PCR fragment 1 diff to 4H23v1
           Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNTSKQVTLAGLTVPPNTNISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV

CYP4H23v4  Culex pipiens
           GenEMBL AF190783
           Changliang Zhu
           Clone NYDR8 PCR fragment 2 diffs with 4H23v1
           Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNISKQVSLAGLTVPPNTSISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV

CYP4H24    Anopheles Gambiae (mosquito)
           No accession number
           Hilary Ranson
           Submitted to nomenclature committee 10/15/2001
           82% to CYP4H7
           clone name Cyp43_3

CYP4H24     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPa1x2

CYP4H25     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPc2r3

CYP4H26     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPc2r4

CYP4H27     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs3r1

CYP4H28    Aedes aegypti (yellow fever mosquito)

CYP4H28    Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4T2.2

CYP4H29    Aedes aegypti (yellow fever mosquito)

CYP4H29    Aedes aegypti (mosquito)
           No accession number
           David, J-P  and Dauphin-Villemant, C.
           I-helix to heme fragment
           Clone name 4I1.8

CYP4H30    Aedes aegypti (yellow fever mosquito)

CYP4H30    Culex pipiens

CYP4H31    Aedes aegypti (yellow fever mosquito)

CYP4H31    Culex pipiens

CYP4H32    Aedes aegypti (yellow fever mosquito)

CYP4H33    Aedes aegypti (yellow fever mosquito)

CYP4H34    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/19/07
           sequence 4
           58% to CYP4H31 Aedes, 66% to 4H12v5 and 4H12v4

CYP4H34    Culex pipiens

CYP4H35    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 8
           74% to 4H29 Aedes, 59% to 4H15 Anoph., 59% to 4H25 Anoph., 
           40% to 4D1, 44% to 4H34, 45% to 4D40
           The 4H subfamily seems to need to be split

CYP4H35    Culex pipiens

CYP4H36    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 9
           72% to 4H29 Aedes, 60% to 4H15 Anoph., 44% to 4H34

CYP4H36    Culex pipiens

CYP4H37    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 10
           62% to 4H19 Anoph., 62% to 4H31 Aedes, 59% to 4H34

CYP4H37v1  Culex pipiens

CYP4H37v2  Culex pipiens

CYP4H38    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 16
           70% to 4H18 Anoph., 79% to 4H33 Aedes, 53% to 4H34

CYP4H38    Culex pipiens

CYP4H39    Culex pipiens

CYP4H40    Culex pipiens

CYP4H41    Culex pipiens

CYP4H42v1  Aedes albopictus
           No accession number
           Silas Avicor
           submitted to nomenclature committee 3/27/13
           73% to CYP4H30 Aedes aegypti
           100% to CYP4H42v2 in protein seq
           8 nucleotide diffs in coding region
           97% to CYP4H43 Aeded albopictus

CYP4H42v2  Aedes albopictus
           No accession number
           Silas Avicor
           submitted to nomenclature committee 3/27/13
           73% to CYP4H30 Aedes aegypti
           100% to CYP4H42v1 in protein seq
           8 nucleotide diffs in coding region
           97% to CYP4H43 Aeded albopictus

CYP4H43    Aedes albopictus
           No accession number
           Silas Avicor
           submitted to nomenclature committee 3/27/13
           72% to CYP4H30 Aedes aegypti
           97% to CYP4H42v1 in protein seq

CYP4I      I and O are not used in this nomenclature

4J Subfamily

CYP4J1      Anopheles albimanus (mosquito)
            GenEMBL L38691 (433bp) PIR PC2258 (124 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4J2      Anopheles albimanus (mosquito)
            GenEMBL L38692 (397bp) PIR PC2259 (132 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4J3      Anopheles albimanus (mosquito)
            GenEMBL L38693 (385bp) PIR PC2260 (128 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4J4    Culex pipiens
          CPIJ016284

CYP4J4v1   Culex pipiens pallens (mosquito)
           AF157092
           Zhu Changliang, Dept. of Parasitology, Nanjing University
           submitted to nomenclature committee 5/20/99
           PCR C-terminal fragment 149 amino acids
           clone name NYDR4 63% identical to 4J2 
EVDTFMFEGHDTTASALVFIFFQLAREQTVQEHIFNEIHALYDR
KPQADKSFRPQDYAELKFMDRALKECLRLWPPVTFISRAITDDIILADGALLPAGCVG
NVQIFDLHRDPEQFPDPERFDPDRFLPESVDKRNPYAYVPFTAGPRNCIG

CYP4J4v2   Culex pipiens
           No accession number
           Changliang Zhu
           Clone NYDS5 PCR fragment 96% identical to 4J4v1
           Submitted to nomenclature committee 9/30/99
TASALVFIFFQLAREQTVQERIFNEIHALYDRKPQADKSFRPQD
YAELKFMDRALKECLRLWPPVTFISRAITDDIVLADGALLPAGCVANVQIFDLHRDPE
QFPDPERFDPDGFLPESVDKRNPYAYV

CYP4J5     Anopheles gambiae
           no accession number
           Hilary Ranson
           Submitted to nomenclature committee 8/9/99
           clone name P450J
           66% identical to 4J2

CYP4J5      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPk2l2

CYP4J6    Culex pipiens
          CPIJ001754

CYP4J6v1   Culex pipiens
           GenEMBL AF190776
           Changliang Zhu
           Clone NYDS3 PCR fragment 95% identical to 4J6v2, 59% to 4J3
           Submitted to nomenclature committee 9/30/99
TASAVTFIFFVVAEHPDVQQKLCDEIEASSPHSQYTVKDYNELR
YMDRVIKECLRLYPPVPFIGRTVSEDSWFADHFVPKGSMANVHIWDLYRDPEQFPDPE
RFDPDRFLPENVEKRNPYAYV

CYP4J6v2   Culex pipiens
           AF190781
           Changliang Zhu
           Clone NYDR6 PCR fragment 95% identical to 4J6v1
           Submitted to nomenclature committee 9/30/99
TASAVTFIFFVVAEHPDVQQKLYDEIEASRPHSQYTVKDYNELR
YMDRVIKECLRLYPPVPFIGRTVSEDSWFADRFVPKGSMANVHIWDLHRDPDQFPDPE
RFDPDRFLPESVEKRNPYAYV

CYP4J7v1   Culex pipiens
           GenEMBL AF190780
           Changliang Zhu
           Clone NYDR5 PCR fragment 96% identical to 4J7v2, 60% to 4J3
           Submitted to nomenclature committee 9/30/99
TASAFTFIFLLVAEHSDVQQALVDEILTVNSSRLDPLAQFTVKD
YNELRYMDRVIKECLRLYPPVPFIGRMINEDSWFGDRFIPKDSMANVLIWDLHRDPKQ
FLDPERFDPDRFLPENVGQRNPYAYV

CYP4J7v2   Culex pipiens
           AF190785
           Changliang Zhu
           Clone NYDR10 PCR fragment 96% identical to 4J7v1
           Submitted to nomenclature committee 9/30/99
TASAFTFIFLLVAEHSDVQQALVDEILTVNSSRLDPLAQFTVKD
YNEFRYMDRVIKECLRLYPPVPFIGRMINEDSWFGYRFIPKDSMANVLIWDLHRDPRQ
FLDPERFDPDRFLPENVEQRNPYAYV

CYP4J8v1   Culex pipiens
           GenEMBL AF190788
           Changliang Zhu
           Clone NYDR13 PCR fragment 61% identical to 4J6v2
           Submitted to nomenclature committee 9/30/99
TGSAFVFIFLSIANHQDVQERVYQEVHATLHDRSGPAEPLTIQD
YNNLKYMERVLKECMRVYPPVPFISRFVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQ
FPDPERFDPDRFLPEHVEKRNPYAYV

CYP4J8v2   Culex pipiens pallens
           CB074944.1
           NJS16171(1) 490bp, NJ001 in Genbank entry
           98% to 4J8v3, 3 diffs, 61% to 4J10 97% to 4J8v1
NSLVIEVDTFMFEGHDTTGSAFVFIFLSIANHQDVQERVYQEIHATLHDRSDPAEPLTIQ
DYNNLKYMERVLKECMRVYPPVPFISRYVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQF
PDPERFDPDRFLPEHVEKRNPYAYVPFSAGPRNCIGQNRIPAA

CYP4J8v3  Culex pipiens pallens
          CB074947.1 
          NJS1618(8) 490bp, NJ004 in Genbank entry
          98% to CYP4J8v2, 3 diffs, 59% to 4J10 97% to 4J8v1
NSLVIEVDTFMFEGHDTTGSAFVFIFLSIANHQDDQERVYQEIHATLHDRSDPAEPLTIQ
DYNNLKYMERVLKECMRVYPPVPFISRFVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQF
PDPERFDPDRFLPEHVEKRNPYAYVPFTAGPRNCIGQNRIPAA

CYP4J9      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPk2l1

CYP4J9      Anopheles funestus
            No accession number 
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            Submitted to nomenclature committee 1/5/05
            88% to 4J9 A. gambiae probable ortholog, 56% to 4J5

CYP4J10     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPk2l3

CYP4J11    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 1 
           79% TO 4J5 57% TO CONTIG 7 probable ortholog of 4J5
           60% to 4J9 and 58% to 4J10

CYP4J12    Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 5/13/04
           Contig 6 and contig 7 (1 aa diff)
           83% TO 4J10 54% to 4J9 and 53% to 4J5
           probable ortholog of 4J10

CYP4J13    Aedes aegypti (yellow fever mosquito)

CYP4J13   Culex pipiens

CYP4J14    Aedes aegypti (yellow fever mosquito)

CYP4J15v1  Aedes aegypti (yellow fever mosquito)

CYP4J15v2  Aedes aegypti (yellow fever mosquito)

CYP4J16    Aedes aegypti (yellow fever mosquito)

CYP4J17    Aedes aegypti (yellow fever mosquito)

CYP4J18    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 14
           68% to 4J16 Aedes, 54% to 4J9 Anoph.

CYP4J18   Culex pipiens

CYP4J19    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 12
           59% to 4J9 Anoph., 71% to 4J19 Aedes

CYP4J19   Culex pipiens

CYP4J20    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 13
           54% to 4J5 Anoph., 50% to 4J13 Aedes

CYP4J20   Culex pipiens

4K Subfamily

CYP4K1      Anopheles albimanus (mosquito)
            GenEMBL L38694 (379bp) PIR PC2273 (126 amino acids)
            Scott, J.A., Collins,F.H. and Feyereisen, R.
            Diversity of cytochrome P450 genes in the mosquito, Anopheles 
            albimanus.
            Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)

CYP4K2      Anopheles gambiae (mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            73% to 4K1 fragment
            SLRAICLH sequence not seen in 4K1 probably bad      
            joint

CYP4K2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPe2r1
            Note very similar to CYP4AR1 (almost in the same subfamily)

CYP4K3      Aedes aegypti (yellow fever mosquito)

CYP4K3    Culex pipiens

4L Subfamily

CYP4L1      Manduca sexta (tobacco hornworm)
            GenEMBL L38668 (391bp)
            Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R. 
            Expression of cytochrome P450 genes of the CYP4 family in midgut and 
            fat body of the tobacco hornworm, Manduca sexta.
            Arch. Biochem. Biophys. 321, 13-20 (1995)

CYP4L2      Manduca sexta (tobacco hornworm)
            GenEMBL L38669 (394bp)
            Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R. 
            Expression of cytochrome P450 genes of the CYP4 family in midgut and 
            fat body of the tobacco hornworm, Manduca sexta.
            Arch. Biochem. Biophys. 321, 13-20 (1995)

CYP4L2     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4L3      Helicoverpa armigera (Australian cotton bollworm) 
            no accesssion number
            Kate Aronstein and Richard ffrench-Constant
            submitted to nomenclature committee
            called evacyp4

CYP4L4      Mamestra brassicae (moth)
            GenEMBL AY063501
            Martine Maibeche 
            59% to 4L1 (partial seq)
            clone name MbraC5 full length
            submitted to nomenclature committee Oct. 5 2001

CYP4L5      Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            100% identical to Grubors seq

CYP4L5      Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            Sequence #9 HaCypZ012a-v1Pep
            85% to 4L4

CYP4L5     Helicoverpa armigera (cotton bollworm)
           No accession number
           Heiko Vogel 
           submitted to nomenclature committee Feb. 6, 2008
           Contig_173 100% to CYP4L5
           HAH001637 100% to Contig_173, 1 aa diff to Contig_172
           Contig_172 1 aa diff to Contig_173
           HAH001562_2 1 aa diff to Contig_173
           Contig_186 1 aa diff to Contig_173

CYP4L5      Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            93% to CYP4L5 Helicoverpa armigera

CYP4L6      Bombyx mori (silkworm)
            CK535040 BP182824 ESTs
            BAAB01121615.1 BAAB01097697.1 BAAB01093085.1 BAAB01107041.1
            See silkworm page for sequence

CYP4L7      Spodoptera exigua (beet armyworm)
            No accession
            Katsuya Natsuhara
            Submitted to nomenclature committee July 26, 2004
            75% to 4L4

CYP4L8      Spodoptera littoralis (cotton leafworm)
            No accession number
            Lyndsay Davies
            Submitted to nomenclature committee July 7, 2005
            Clone A4
            78% to CYP4L4, 91% to CYP4L7

CYP4L9v1    Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SA3 97% to 4L9v2, 3 aa diffs,  
            87% to 4L4, 91% to 4L7, 88% to 4L8

CYP4L9v2    Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name RAG1 97% to 4L9v1, 3 aa diffs,  
            87% to 4L4 89% to 4L7 86% to 4L8 

CYP4L9      Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            86% to CYP4L13, 80% to CYP4L12, 77% to 4L5
            86% to 4L7, 78% to 4L4, 97% to 4L9v1 (4 aa diffs, 
            probable ortholog), 95% to 4L9v2 (6 aa diffs)
            89% to 4L8, 88% to 4L10

CYP4L10     Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name RT5 98% to 4L8 2 aa diffs, 
            78% to 4L4 possible ortholog of 4L8

CYP4L10     Spodoptera litura (common cutworm)
            No accession number
            Gangfeng Shao
            Submitted to nomenclature committee 12/17/2008
            Partial sequence I-helix to heme
            100% to CYP4L10 of Huang

CYP4L11     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            86% to CYP4L5 Helicoverpa armigera 80% TO 4L3 Helicoverpa armigera
            83% to 4L9v1, 80% to 4L10, 80% to 4L8

CYP4L11     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_158 3 aa diffs to CYP4L11 of Rene Feyereisen
            HAH001562 100% to Contig_158

CYP4L12     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            86% to 4L5, 80% to CYP4L9, 77% to 4L11,  76% to CYP4L13
            89% to 4L4, 87% to 4L9, 78% to 4L8, 77% to 4L10

CYP4L12     Spodoptera littoralis
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            95% to CYP4L12 Spodoptera frugiperda (ortholog)

CYP4L13     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            86% to CYP4L9, 76% to CYP4L12, 72% to 4L5, 69% to 4L11
            86% to 4L7, 74% to 4L4, 89% to 4L9v1, 89% to 4L8, 
            88% to 4L10, 87% to 4L9v2

CYP4L14     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_218 94% to Contig_173 CYP4L5

CYP4L15     Spodoptera exigua (beet armyworm)
            No accession number
            Gangfeng Shao
            Submitted to nomenclature committee 12/17/2008
            Partial sequence I-helix to heme
            94% to CYP4L4, 97% to CYP4L16

CYP4L16     Spodoptera exigua (beet armyworm)
            No accession number
            Gangfeng Shao
            Submitted to nomenclature committee 12/17/2008
            Partial sequence I-helix to heme
            93% to CYP4L4, 97% to CYP4L15

CYP4L17    Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_P450-12 
           49% to CYP4L4, 48% to CYP4L7, 
           probable ortholog of other CYP4Ls in moths

CYP4L18    Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee April 13, 2009
           clone name: CM4-2
           58% to CYP4L4 Mamestra brassicae
           55% to CYP4L7 Spodoptera exigua

CYP4L19    Spodoptera litura
           No accession number
           Gangfeng Shao
           Submitted to nomenclature committee May 22, 2009
           94% to CYP4L4 Mamestra brassicae, 97% to CYP4L15 Spodoptera litura
           97% to CYP4L21, 97% to CYP4L20

CYP4L20    Spodoptera litura
           No accession number
           Gangfeng Shao
           Submitted to nomenclature committee May 22, 2009
           92% to CYP4L4, 95% to CYP4L15 Spodoptera litura, 97% TO CYP4L19,
           97% to CYP4L21

CYP4L21    Spodoptera litura
           No accession number
           Gangfeng Shao
           Submitted to nomenclature committee May 22, 2009
           92% to CYP4L4, 96% to CYP4L15 Spodoptera litura, 
           97% TO CYP4L19, 97% TO CYP4L20

CYP4L22     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            56% to CYP4L4 Mamestra brassicae

CYP4L23    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP4L24    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP4L25    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

4M Subfamily

CYP4M1      Manduca sexta (tobacco hornworm)
            GenEMBL L38670 (397bp)
            Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R. 
            Expression of cytochrome P450 genes of the CYP4 family in midgut and 
            fat body of the tobacco hornworm, Manduca sexta.
            Arch. Biochem. Biophys. 321, 13-20 (1995)

CYP4M1     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4M2      Manduca sexta (tobacco hornworm)
            GenEMBL L38671 (1512bp)
            Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R. 
            Expression of cytochrome P450 genes of the CYP4 family in midgut and 
            fat body of the tobacco hornworm, Manduca sexta.
            Arch. Biochem. Biophys. 321, 13-20 (1995)

CYP4M2     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4M3X     Manduca sexta (tobacco hornworm)
            GenEMBL L38672 (397bp)
            Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R. 
            Expression of cytochrome P450 genes of the CYP4 family in midgut and 
            fat body of the tobacco hornworm, Manduca sexta.
            Arch. Biochem. Biophys. 321, 13-20 (1995)
            Name changed to CYP4CG1

CYP4M4v1    Helicoverpa armigera (Australian cotton bollworm) 
            GenEMBL U86005
            Pittendrigh,B., Aronstein,K., Zinkovsky,E., Andreev,O.,
            Campbell,B., Daly,J., Trowell,S. and ffrench-Constant,R.H.
            Cytochrome P450 genes from Helicoverpa armigera: expression in a
            pyrethroid-susceptible and -resistant strain
            Insect Biochem. Mol. Biol. 27 (6), 507-512 (1997)
            hacyp63

CYP4M4v2    Helicoverpa armigera (Australian cotton bollworm)
            GenEMBL AF182171
            99% to 4M6 in H. zea = ortholog
            98% to 4M4v1 (2 aa diffs)

CYP4M4?     Helicoverpa armigera (Australian cotton bollworm)
            No accession number 
            Vladimir Grubor 
            submitted to nomenclature committee Dec. 30, 2003
            100% overlap with CYP4M4v2 (14aa) C-term frag. 70 aa 
            seq #16 HaCypZ019a-v1Pep
            this seq may be the C-terminal of CYP4M4

CYP4M5      Bombyx mori (silkworm)
            No accession number
            Kyoko Kikuchi
            54% to 4M2 71% to partial 4M1 sequence 74% to 4M4 partial seq.
            submitted to nomenclature committee Jan. 16, 2001

CYP4M6      Helicoverpa zea (corn earworm)
            GenEMBL AY113687
            Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
            submitted to nomenclature committee June 15, 2001
            Clone name x32 
            501 aa 54% to 4M2

CYP4M6v1    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            98% (9 aa diffs) to CYP4M6 AY113687 Helicoverpa zea 
            (corn earworm) ortholog

CYP4M6v2    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH005656 97% to CYP4M6v1

CYP4M7      Helicoverpa zea (corn earworm)
            GenEMBL AY113688
            Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
            submitted to nomenclature committee June 15, 2001
            Clone name x39 
            502 aa 53% to 4M2 77% to 4M4 I-helix to heme

CYP4M7v1    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            99% 6 aa diffs to CYP4M7 AY113688 Helicoverpa zea 
            (corn earworm) ortholog

CYP4M7v2    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_194 97% to CYP4M7
            HAH003557 100% to Contig_194

CYP4M8      Trichoplusia ni Family: Noctuidae (caterpillar) 
            No accession number
            Ping Wang
            54% to 4M2 70% to 4M1 I-helix to heme (sequence 2)
            submitted to nomenclature committee 5/20/02

CYP4M9      Bombyx mori (silkworm)
            BAAB01103156.1 BAAB01142776.1 BAAB01178932.1 
            57% to 4M5
            See silkworm page for sequence

CYP4M10v1   Helicoverpa armigera (cotton bollworm)
            No accession number
            David G. Heckel 
            submitted to nomenclature committee Feb. 21, 2005
            HaCypZ020a-v1Pep 
            67% to 4M7

CYP4M10v1   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            1 aa diff to Heckels seq

CYP4M10v2   Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH001186 has 4 aa diffs to CYP4M10v1
            Contig_155 has 1 aa diff to HAH001186
            Contig_225 2 aa diffs to Contig_155

CYP4M11     Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee June 12, 2005
            Clone name sequence 2
            70% to CYP4M6 but only I-helix to heme fragment

CYP4M12v1   Spodoptera littoralis (cotton leafworm)
            No accession number
            Lyndsay Davies
            Submitted to nomenclature committee July 7, 2005
            Clone A1
            76% to CYP4S2 

CYP4M12v2   Spodoptera littoralis (cotton leafworm)
            No accession number
            Lyndsay Davies
            Submitted to nomenclature committee July 7, 2005
            Clone A11
            2 aa diffs to CYP4M12v1

CYP4M13v1   Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name RT4 83% to 4M6, 
            98% or 2 aa diffs to CYP4M12v1 possible ortholog 

CYP4M13v2   Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SC4 97% to 4M13v1, 
            possible allele, 96% to 4M12v1, 81% to 4M6

CYP4M14v1   Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name R35 79% to 4M6

CYP4M14v2   Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SB2 99% (1 aa diff) to CYP4M14v1, 
            78% to 4M6, 89% to CYP4M15

CYP4M14     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            86% to 4M15, 77% to 4M10, 69% to 4M6, 67% to 4M7,
            65% to 4M17, 64% to 4M18, 69% to 4M6, 91% to 4M14v1 
            and v2, 89% to 4M15, 79% to 4M4v2, 75% to 4M13v1, 
            75% to 4M12v1, 61% to 4M16, 63% TO 4M11, 65% TO 4M8
            possible ortholog of CYP4M14 Spodoptera litura (common cutworm)

CYP4M15     Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name R31 89% to 4M14v2, 81% to 4M6

CYP4M15     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            86% to 4M14, 79% to 4M10, 71% to 4M7, 70% to 4M6, 67% to 4M17, 
            66% to 4M18, 71% TO 4M7, 65% to 4M8, 62% to 4M16, 
            96% to 4M15 (5 aa diffs),
            90% to 4M14v1, 76% to 4M13v1, 77% to 4M12v1, 68% to 4M11
            possible ortholog of CYP4M15 Spodoptera litura (common cutworm)

CYP4M16     Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SD1 65% to CYP4M14v1, 63% to 4M7

CYP4M17     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            74% to 4M7, 78% to 4M14v1, 73% to 4M13v1, 75% to 4M15, 
            73% to 4M12v1, 69% to 4M11, 65% to 4M16

CYP4M18     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            95% to 4M13v1 (6 aa diffs in 149aa), 96% to 4M12v1 (5 aa diffs in 
            149aa), 77% to 4M15, 73% to 4M14v1, 65% to 4M16, possible ortholog of
            CYP4M12 or 4M13.

CYP4M19     Plutella xylostella (L.) (diamondback moth, Lepidoptera)
            GenEMBL EU189047.1, GenPept ABW34434
            Jihyeong Baek
            submitted to nomenclature committee Dec. 3, 2007
            5 aa diffs to 4M11 this might be a CYP4M11 allele
MFEGHDTTATGLVYLLMSLACDKMIQDKVVEELKEIFGDSTRPA
TMQDLGKMKYLDCCIKESLRLYPPVPFIARILNEEVVLSGYKVPAGTQCNIHIYDLHR
RADLFENPSKFDPDRFLPKNSAGRHPYAYIPFSAGPRNCIGQK

CYP4M20     Plutella xylostella (L.) (diamondback moth, Lepidoptera)
            GenEMBL EU189048.1, GenPept ABW34435
            Jihyeong Baek
            submitted to nomenclature committee Dec. 3, 2007
            75% to 4M15 Spodoptera litura
MFEGHDTTASGLVYFLMLLANHRDIQKKVTAELDSIFGSSDRPA
SMADLARMRYLDCCVKESLRLYPPVPFISRELQEPVVLSNYTIPSGMFVHIHIFDLHR
REDLFPDADRFDPDRFLPENSAGRHPYAYIPFSAGPRNCIGQK

CYP4M21     Plutella xylostella (L.) (diamondback moth, Lepidoptera)
            GenEMBL EU189049.1, GenPept ABW34436
            Jihyeong Baek
            submitted to nomenclature committee Dec. 3, 2007
            61% to 4M19 Plutella xylostella
MFEGHDTTARALCFLLMSIANEPIVQDTISSELQDIFQGSDRPP
TVEDLHEMKYLECCIREGLRLYPSVPYIARLLKEDTVLSGYVVPAGTIVNIHVFDVHR
RAELFPEPEAFRPERWLAPPPHKYAYVPFSAGPRNCIGQK

CYP4M22     Plutella xylostella (L.) (diamondback moth, Lepidoptera)
            GenEMBL EU189050.1, GenPept ABW34437
            Jihyeong Baek
            submitted to nomenclature committee Dec. 3, 2007
            65% to 4M19, 65% to 4M5
MFEGHDTTAMGLTFILMELANNPSVQDKVVQELREIFGQSARPG
SMQDMSQMKYLECCIKETLRLYPPVPFISRYITDTVTLSGHVIPRGKTLCHIHIFDLH
RRADLYPSPLVFNPEQFTAGNCASRHPYAYIPFSGGPRNCIGQK

CYP4M22    Plutella xylostella 
           Gene number CCG006053.1b
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           95% to CYP4M22 short fragment (I-helix to heme) 
           with 7 aa diffs (one on the end)
           two genes fused

CYP4M23     Plutella xylostella (L.) (diamondback moth, Lepidoptera)
            GenEMBL EU189051.1, GenPept ABW34438
            Jihyeong Baek
            submitted to nomenclature committee Dec. 3, 2007
            62% to 4M6 Helicoverpa zea
MFEGHDTTSTALQMIFMLLANNVDSQDKIVEECDRIFGSSDRSA
TMDDLTQMKYLECCIKEGLRLFPPVFFIQRMLTEPMKFREHEVPAGTDCTVFILDLHR
RADQFDEPHSFRPERFLAESPSWHPYSYIPFSAGPRNCIGQKI

CYP4M23    Plutella xylostella 
           Gene number CCG006053.1a
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           96% to CYP4M23 (I-helix to heme) 3 aa diffs (two on the end)
           Two genes fused

CYP4M24     Ostrinia furnacalis (Asian corn borer)
            No accession number
            Zhang Yuliang
            submitted to nomenclature committee Feb. 17, 2009
            77% to CYP4M6, partial sequence

CYP4M25    Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee April 13, 2009
           clone name: CM4-1
           59% to CYP4M7 Helicoverpa zea

CYP4M26    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4M27     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            53% to CYP4M10v1 Helicoverpa armigera

CYP4M28     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee May 20, 2011

CYP4M29     Ostrinia nubilalis (European corn borer)
            GH996933
            
CYP4M30     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            90% to CYP4M7 Helicoverpa zea

CYP4M31     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            95% to CYP4M6 Helicoverpa zea

CYP4M31     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            98% to CYP4M31 Heliothis subflexa

CYP4M32     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            83% to CYP4M16 Spodoptera litura

CYP4M33    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP4M34    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

4N Subfamily

CYP4N1      Musca domestica
            Rene Feyereisen
            submitted to nomenclature committee

CYP4N2      Musca domestica (house fly)
            Rene Feyereisen
            submitted to nomenclature committee

CYP4N3X see CYP4D8

CYP4N4X see CYP4E4

CYP4O1      I and O not used in this nomenclature

4P Subfamily

Cyp4p1      Drosophila melanogaster
            GenEMBL U34327(379bp)
            Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
            ffrench-Constant,R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genet. 251, 290-297 (1996)

Cyp4p1      Drosophila melanogaster
            GenEMBL AC018129 comp(67703-69662)
            ESTs AI405947 AI109737 AI293255 
            GSS AL063060 722-913

Cyp4p1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4p2      Drosophila melanogaster
            GenEMBL AC018129 comp(70087-72192)
            EST AI389883 
            GSS AL055774 comp(4-805) AL063060 28-294

Cyp4p2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4p3      Drosophila melanogaster
            GenEMBL AC018129 comp(65426-67385)
            No ESTs no GSSs

Cyp4p3      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4P4      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4P 
            63% to 4P1  (140 aa)

CYP4P5      Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            56% to CYP4p1 Drosophila melanogaster

CYP4P6      Bactrocera orientalis (oriental fruit fly)
            No accession number
            Yong Huang
            Submitted to nomenclature committee March 16, 2012
            66% to CYP4P5 Bactrocera dorsalis

4Q Subfamily

CYP4Q1     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           S2
           submitted to nomenclature committee

CYP4Q1     Tribolium castaneum (red flour beetle)
           GenEMBL XP_971238
           69% to CYP4Q2, 63% to 4Q7
MLLSTTLVCAIGLLGVFHLLAWIKFHASNYMKMCVIPGPPQKGILIGNMTYLQTTPEKIFLRLREATKNF
YPIYKLNALHKCAANILNPEDCELIMSNSAHNQKGQIYDLLRNWLKDGLLTSFGAKWQTRRKILTPAFHF
SILQQFVQIFNEEAEILVEDLKKDCSKSYISISSHITKFTLKTIAETAMGSKLKFETQKEIDYYQAVYDV
GKILLYRLTHPWFIFHYVNFFSPWYLQEVKVTKTLHNFTREVIKHREENFKDIELPTEEHEVYKGKKRLA
MLDLLLSAKHKEGIVENDGIQEEVDTFMFKGHDTTSAALCFALMLIASHSEVQESIVAEMREVLGDLSKK
PSYNDLQNLKYLERCIKETLRLYPSVHFISRTLGQDLITTGGYTLPKESNAIIHIYDVHHNADIYPDPEK
FDPDRFLPENVQKRHPYAYLPFSAGPRNCIGQRFAMLELKTAICAILANFTLQPIDTPETIILVVDIILR
TKEPIKIKFVPRS

CYP4Q2     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           S35
           submitted to nomenclature committee

CYP4Q2     Tribolium castaneum (red flour beetle)
           GenEMBL XP_971175
           69% to CYP4Q1
MFASTLILTTIFAIVSVLAFKRIKYHVKNYILLNKLPGPPPDGLFVGNMPYLQTTPEDIFNRLREANKKF
YPIYKLFAVHRMGANILSPEDSEIVLSNPIHNEKGYIYKLLHHWLKEGLLTSKGEKWQLRRKILTPAFHF
NILQQFIMILNEEAEKLVEGLRKECHKPYINITPHISQFTLKSITETAMGTKLDFTTKKEIRYKEAVYKI
GKILTYRITHPWFIEPLLNIFSPCFIQERRVTSTLHKFTKEVIEDREKNFKDFELPTEEHDVYKGKKRLA
MLDLLLSAKKKDGIIDNKGIQEEVDTFMFEGHDTTAVALNFALMLIACHKDVQETILQEMRDVLGDIHAK
PTYSDLQNLKYLERCIKESLRLYPSVHLISRALGEDVRTQKGYLIPKDTITIIHIYDLHHNPDIYPDPEK
FDPDRFLPENCQNRHPFAYLPFSAGPRNCIGQRFAMLELKAAICAILANFVLEPIDTPETIVVVVDIVLR
TKEGIKIRFVPREQ

CYP4Q3     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           R15
           submitted to nomenclature committee

CYP4Q3     Tribolium castaneum (red flour beetle)
           GenEMBL XP_971112
           66% to 4Q7
MLLSSSVLFVISFFLVLYFFKKLKCVSAKLYNLGKLDGPSNHNIIIGNVLRLH
AAPEVIFKKLRQWARDYYPVYQLRAIHIPAACILAPEDFEAILSNPRHIEKSMVYLLLHDWLGTGLLTSG
GQKWATRRKILTPAFHFSILQQFITIFNEETDKLVDTFKQQCDQPIEITSHITQFTLKTIGETAMGTKFE
FTTRKQIEYKQAILEIGEILLYRLLNSWLISDYLNFFSPHRLREKRLVKTLHTFTRDVITEREKTFEKFQ
LPTEEHDVYIGKKRLAMLDLLLTAKNEERTIDEDGIREEVDTFMFEGHDTTSAALSFALMLLANHKNVQD
QIVDEMVTVLGDLHQKPTYNNLQEMKYLERAIKESLRLYPSVHFISRKLGEDFVTCNGLKLPKSTITHLH
IYDLHHNPDIYPDPEKFDPERFRPENSQKRHPFAYLPFSAGPRNCIGQKFAMLELKAAICGILANFILEP
VDTPESIVLVVDLVLRTKNGIKIGFIPRVK

CYP4Q4     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           S1
           submitted to nomenclature committee

CYP4Q4     Tribolium castaneum (red flour beetle)
           GenEMBL AAP94193, 98% to AF251548_1 (7 aa diffs)
           57% to 4Q5
MFLAPIILCLVLLALLVSSLRKKGRFWECLAPIPQPPAYPIIGNLFDIMRTPEQMFLADRERGLKYYPIY
KLDVCGTGGVNLLNPEDVELVLTDTKQNTKSFIYHFLHSWLGTGLLTSRGPKWQNRRKILTPAFHFNILQ
EFIQIFNEETKRLVEDLEAESHKPYIDVVVPITQFTLLSIGETAMGIKLNASDNDKDGYKRAVYKIGQLL
TYRAPRPWIHNETIYSLTPQGRKEQKVLKSLHSFSNNVIAERKKHFSSSSYSSRKRLAMLDLLLKYKSEG
ANIDDEGIREEVDTFMFEGHDTTSVSICYTLMLLANHREVQEEILKEMEAVLDEEPPTYAKLQELKFMDR
VIKESLRLYPSVPFISRVSGSEIQTKTGYTIPKDCMVNLQIYDMHHNPNVFPDPEKFDPDRFLPENIQKR
HPFAYIPFSAGSRNCIGQKFAMLEIKTVLCGILKKFILEAVDTRKDMAFVSDLVLRPKGSIKVKFVPRRAN

CYP4Q5     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           S58
           submitted to nomenclature committee

CYP4Q5     Tribolium castaneum (red flour beetle)
           GenEMBL XP_971423
           57% to 4Q4
MIQSTLLLIFIVILSVIIYIWWYQNFSRFFSLLNKVPGPPGYPIIGNIIQFLATPEELFKIDRELGRRFY
PIYKEWTLTYGAVNLLHPDDIELVLSNSKYNDKSAIYDFLHCWLGTGLLTSSGTKWQTRRKVLTPAFHFN
ILQQFLPIFNEETVKLIKNIKNDQPIDVIPPVTQFTLLSIAETSMGVKLDASPKSCDDYKNAIHVFGYAL
TYRLGRPWLHNPFVFFNLTRLGHLTKKSIKILHDFSRNVIEQKKRTFEGEKRGKRLAMLDLLLLAKHQGA
DIDDEGIAEEVDTFMFEGHDTTSIAICYTLLLLANHPDIQDELYSELKSVLSDPTQTPSYSDLKQLNLME
RCIKESLRIFPSVPFISRLLTEDLTTASGYVIPRGSMAHIHIYDLHNNPEIYPDPKKFDPDRFLPENCQK
RHPFAYLPFSAGPRNCIGQKFAMLELKVVLSGILGNFVLEAVDKPKDVTMITDLVLRCKGPIRVKFVPRYKIN

CYP4Q6     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           R4
           submitted to nomenclature committee

CYP4Q6     Tribolium castaneum (red flour beetle)
           GenEMBL XP_970404, AAJJ01002630.1
           54% to 4Q4
MLSFYLLLTGVGLILLLQTWRFFRKYFKNKTILKKIRGPPETPIFGHMYIFTQDP (1)
DLLFSRIRKYSREYYPIFRFSALYVDIVNFLEPNDIELILSTTKHLSKSKIYTFLNNWLGTG
LLTSTGAKWHQRRKILTPAFHFNILQQFLNIFNDETEKLVLRLGEDCGRTIDVVPPVTNFTLQSIAETAM
GLSNINELTQKEYKKAIYKIGHIFLKRLSKPWYRLDAIYNYSKLAEEENATVKILHDFSNGIISEREKER
TTNLSQNLASYSKKKRMAMLDLLLAAKNEGADIDYEGIREEVDTFMFEGHDTTSMAISFILLTLANLQDV
QTKVREEILSVVGKEKIPTYNDLQELKYTERCIKETLRLFPSVPFISRYASEDFVTKTGYTIPEGTVLHI
HIFDLHRNAEIYPDPLKFDPDRFLPEKVNERHPFAYIPFSAGPRNCIGQKFAFLELKTVLCGILRKFKLE
KVDDMYEIEFRPDLVLRPKNDVKVRIEKL

CYP4Q7     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           formerly CYP4R1 (sequence revised 1/29/99)
           submitted to nomenclature committee

CYP4Q7     Tribolium castaneum (red flour beetle)
           GenEMBL AF254755_1
           66% to 4Q3
MLVLTTVLTAAAVFLLFYLFYCYKTIKQHIYSLISLSYLPGPPVNDIISGNILPLYTSAENIFKQLREWG
RLYYPIYKLNAAHLAAANILSPEDCELVLSNPTHMEKSAIYNLLHDWLGTGLLTSTGLKWQTRRKILTPA
FHFSILQQFVAIFNEETDKLVEVLKEECYKPFINVNAHVAQFTLKTIAETAMGTKLRFTTRKETIYKQSI
VDMGEFLLYRLLRCWLISKCIYVFNPRYYLEKKVTRRLHRFTKSVIAERQENFKEIVVPETDEVYTGKRR
LAMLDLLLTAKNKEGLIDDEGIREEVDTFMFEGHDTTAAALGFALMVLAGHKEVQDKIVEEMNEVLGDIK
KKPTYQDLQEMKYLERCVKEVLRLYPSVHFISRKLGEDLVTHSGHKLAKGSIVNLHIYDLHHNPAIYPDP
EKFDPDRFLPENCQKRHPFAYLPFSAGPRNCIGKKFAMLELKAAICGILANFTLEPIDIPETIVLVVDIV
LRTKEGIKVRFIPRV

CYP4Q8     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           R22
           submitted to nomenclature committee 1/29/99

CYP4Q8     Tribolium castaneum (red flour beetle)
           GenEMBL XP_970987
           68% to 4Q7
           this seq is short
           AAJJ01001877.1 N-term only runs off this contig
           AAJJ01002307.1 C-term part, missing ETAM exon
MVLENIIIGLAAATAICYLFKQLIEMALVIFFVQKMPGPRKFNLFYGNMRPLHSSPAEIFNVLRKWGLEY
YPIYKLWLFFVSVANIMSPEDLALILPDMKHSKKSIAYDLIHRWLGSGLLTSYGTHWQVRRKILTPAFHF
SILQDFILTFNESTEELVELLKKEVEKPFVEITPLITXXXXXXXX
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
PKFYEERKLIKLLHNFTNDIIAKRRKDFHQGIVASQ
KKKRLAMLDLLLTVQKEEGIIDDEGIREEVDTFMFEGHDTVSSAINFALMVLANHPTVQEEIVQEMKDVL
GDTKKKPVYNDLQELKYMERVIKEVLRLYPSVHYISRELGEDMVTTTGYKLRKGTILQLHIYDLHYNPVI
YPEPEKFDPDRFLPENCDKRHPYAYIPFSAGPRNCIGQRFAMLELKAVLCGILSNFTLQPVDTPESIVMV
EDIVLRTKENIKVKFVPREM

CYP4Q9     Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           S25
           submitted to nomenclature committee 1/29/99

CYP4Q9P    Tribolium castaneum (red flour beetle)
           GenEMBL AF265297_2, AAJJ01002307.1,  6 P450s on this contig
           66% to 4Q7
           Some frameshifts and a bad boundary, probable pseudogene
MIILLIIVALVLALFLKPLGHYISIIKYVQQLPGPPCENFLHGNITHLYGPP (1)
EKMFKTVRKWGLEYYPIYQNWIAHVAVANVMNPYDFEV (1?)
ILSNMKH TSKSMIYDMLHCWLGTGLLTSDGIKWQTRRKILTPAFHFNILQEFIKIFNEETETLVQQL
KKHSNSSVDVTEYISAFTLNTIG (1)
ETAMGTSFGTETSTGREYKKSIQEIGEILKYKLLRPWLLSKFVYVCDPNYWKEIKLVKIL
HNFTNNVIANRQSNFKPVEQKSDEFSYSRRKRMAMLDLLLTAKNEDNLIDDEGIREEVD
TFMFEGHDT
2269 TAVAICFALMCIACHPDIQ (0)
ERIFEEIEETFSDDTKPDYKSLQELKYMERCIKEVLRLYPSVPFIARSLGE
DIVTYSGHKLKAGSMVHLHIYDMHHNPQVYPDPEKFDPDRFLPENCLKRHNFAYVFP 2694
SAGPRNCIGQKFAILEMKAVLVGILKEFTLEPVD
VDTPETLVMKTDLVLRAMNGVRVKFVPRICAK*

CYP4Q10     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4Q53c63
            64 amino acids from heme to end
            49% to 4C3, 51% to 4C25, 66% to CYP4Q3 = XP_971112, 
            67% to 4Q11

CYP4Q11     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4G758106
            64 amino acids from heme to end
            53% to 4J9, 52% to 4C3, 68% to CYP4Q8 = XP_970987

CYP4Q11?   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-6
           67% to CYP4Q5 Tribolium castaneum
           62% to CYP4CV1, 63% to CYP4BG2v2
           identical to CYP4Q11 in 18 aa overlap at heme region
           identical to CYP4BN14v1 in 18 aa overlap at heme region

CYP4Q12    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee Dec. 26, 2011
           51% to CYP4Q7v1 Tribolium, best hits are all CYP4Qs
           nearly complete seq.

CYP4Q13    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee Dec. 26, 2011
           49% to CYP4Q12 N-term
           half complete seq.

4R Subfamily

CYP4R1X    Tribolium castaneum (red flour beetle)
           no accession number
           Jeff Stuart
           S11
           submitted to nomenclature committee
           sequence revised now it is CYP4Q7

4S Subfamily

CYP4S1     Helicoverpa armigera (Australian cotton bollworm) 
           no accesssion number
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp59a
           submitted to nomenclature committee

CYP4S1v2   Helicoverpa armigera (cotton bollworm)
           No accession number
           David G. Heckel 
           submitted to nomenclature committee Feb. 21, 2005
           HaCypZ021a-v2Pep
           73% to 4S4 95% to 4S1 only 4 aa diffs not on the extreme ends 
           of the original 4S1 PCR fragment. Probably the same gene.

CYP4S2     Helicoverpa armigera (Australian cotton bollworm) 
           no accesssion number
           Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
           Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
           Cytochrome P450 genes from Helicoverpa armigera: expression in a 
           Pyrethroid susceptible and resistant strain. Submitted
           hacyp58
           submitted to nomenclature committee

Cyp4s3      Drosophila melanogaster
            GenEMBL AC018488 comp(98620-101060) also AC015418 AC018487

Cyp4s3      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4S4      Mamestra brassicae (moth)
            GenEMBL AY063500
            Martine Maibeche 
            86% to 4S1 (partial seq)
            clone name MbraB1 full length
            submitted to nomenclature committee Oct. 5 2001

CYP4S5      Bombyx mori (silkworm)
            BAAB01177041.1 BAAB01181662.1 BAAB01048279.1 BAAB01025317.1
            64% to CYP4S4
            See silkworm page for sequence

CYP4S6      Bombyx mori (silkworm)
            BAAB01121123.1 BAAB01054179.1 BAAB01073078.1 BAAB01008096.1 
            BAAB01081659.1
            94% to 4S5
            See silkworm page for sequence

CYP4S7      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4S 
            71% to 4S3 (266 aa)

CYP4S8v1    Spodoptera littoralis (cotton leafworm)
            No accession number
            Lyndsay Davies
            Submitted to nomenclature committee July 7, 2005
            Clone A2
            76% to 4S2

CYP4S8v1    Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            98% to CYP4S8v4 Spodoptera frugiperda partial seq. (ortholog)

CYP4S8 fragment 1  Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            79% to CYP4S12 Helicoverpa armigera
            (may be the N-term of CYP4S8v1 or an allele
            2 aa diffs in 24 aa overlap)

CYP4S8v2    Spodoptera littoralis (cotton leafworm)
            No accession number
            Lyndsay Davies
            Submitted to nomenclature committee July 7, 2005
            Clone A6
            1 aa diff to CYP4S8v1

CYP4S8v3    Spodoptera littoralis (cotton leafworm)
            No accession number
            Lyndsay Davies
            Submitted to nomenclature committee July 7, 2005
            Clone A9
            1 aa diff to CYP4S8v1

CYP4S8v4    Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SB1 84% to 4S2, identical to 4S8v1 
            except for a short frameshifted region.
            The CYP4S8v1 sequence is probably wrong in this region.

CYP4S9v1    Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name RTH17 78% to 4S4, 97% to 4S9v2

CYP4S9v2    Spodoptera litura (common cutworm)
            No accession number
            Shuijin Huang
            Submitted to nomenclature committee 10/28/2005
            PCR fragment from I-helix to heme
            Clone name SA4 78% to 4S4, 97% to 4S9v1

CYP4S10v1   Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee Dec. 10, 2005
            Clone name Sequence 4  NB5 fragment (C-terminal)
            76% to 4S9v2 73% to 4S4

CYP4S10v2   Plutella xylostella (L.) (diamondback moth, Lepidoptera)
            GenEMBL EU189052.1, GenPept ABW34439
            Jihyeong Baek
            submitted to nomenclature committee Dec. 3, 2007
            1 aa diff to 4S10v1, 75% to 4S9v1

CYP4S10    Plutella xylostella 
           Gene number CCG002092.2
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           98% to CYP4S10v1, nearly complete

CYP4S11     Spodoptera exigua Hubner (beet armyworm)
            No accession number
            Mo Jianchu
            Submitted to nomenclature committee Oct. 30, 2006
            95% to 4S8v4
            146 aa fragment

CYP4S12     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_149 59% to CYP4S5, 44% to CYP4M7
            HAH002398 has 1 aa diff to Contig_149

CYP4S13     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH006401 67% TO CYP4S5, 45% to CYP4M15, 45% to CYP4J9

CYP4S14     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_232 64% to CYP4S13
            HAH001808 100% to Contig_232 95% TO CYP4S12 N-term, 
            56% TO CYP4S5,  54% TO CYP4AX1, 42% to CYP4M10

CYP4S15    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4S16     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            59% to CYP4S13 Helicoverpa armigera

CYP4S17     Heliothis subflexa
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            95% to CYP4S17 Heliothis virescens

CYP4S17     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            90% to CYP4S1v2 Helicoverpa armigera

CYP4S18     Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            66% to Cyp4s3 D. pseudoobscura
            clone name 1141

CYP4S19    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP4S20    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

4T Subfamily

CYP4T1     Oncorhynchus mykiss (rainbow trout)
           GenEMBL U82983
           Patrick Falckh
           closest resemblance to CYP4B

CYP4T2     Dicentrarchus labrax (European sea bass)
           GenBank AF045468
           Sabourault,C., Berge,J., Lafaurie,M., Girard,J.P. and Amichot,M.
           Molecular cloning of a phthalate-inducible CYP4 gene (CYP4T2) in
           kidney from the sea bass, Dicentrarchus labrax.
           Biochem. Biophys. Res. Commun. 251, 213-219 (1998)
           69% identical to 4T1 fragment
           authors name CYP4DL1

CYP4T3v1   Xenopus laevis (African clawed frog)
           GenEMBL AB022671, SwissProt Q9PVV8
           Satoru Yamamoto
           Clone XL-304
           58% identical to CYP4T2 62% to 4T1
           submitted to nomenclature committee Oct 19, 1999
MWNALVWQQVAALLCLLAVLLKATQIYLSKKRQERILEQFPGPP
RHWLLGNVDQIRRDGKDLDLLVNWTQSHGGAYPVWFGNFSSFLFLTHPDYAKVIFGRE
EPKRQLSYNFLVPWIGNGLLVLTGPKWFQHRRLLTPGFHYDVLKPYVKLISKCTTDML
DNWEKLITKQKTVELFQHVSLMTLDSIMKCAFSYESNCQKDSDNAYIKAVFDLSYLAN
LRLRCFPYHNDTIFYLSPpwvsispslqnnsEHTDKVIQQRKESMKHEKELEKIQQKR
HLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQTMEWKDLGKIPYTNMCIKESLRIYPPVPGVARMLRNPVTFFDGR
SIPAGTLVGLSIYAIHKNPAVWEDPEVFNPLRFTPENSANRHSHAFVPFAAGPRNCIG
QNFAMNEMKIAVALTLNRFHLAADLENPPILIPQLVLKSKNGIHVHLNKVQ

CYP4T3v2   Xenopus laevis (African clawed frog)
           SwissProt Q766Z0 100% to Q5XG47
           Yoshiaki Fujita and Hiroaki Ohi
           Submitted to nomenclature committee 7/1/2003
           99% to 4T3 1 aa diff (PCR from I-helix to heme)
TASGISWILYCMAKYPEHQQKCREEIKEVLGDRQTMEWEDLGKIPYTNMCIKESLRIYPP
VPGVARMLRNPVTFFDGRSIPAGTLVGLSIYAIHKNPAVWEDPEVFNPLRFTPENSANRH
SHAFVPFA

CYP4T3v2   Xenopus laevis (African clawed frog)
           SwissProt Q5XG47 
           lower case possibly frameshifted in 4T3v1, 4 other aa diffs
MANEAVLGSMWNALVWQQVAALLCLLAVLLKATQIYLSKKRQERILEQFPGPPRHWLLG
NVDQIRRDGKDLDLLVNWTQSHGGAYPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSLS
YNFLVPWIGNGLLVLTGPKWFQHRRLLTPGFHYDVLKPYVKLISKCTTDMLDNWEKRIT
KQKTVELFQHVSLMTLDSIMKCAFSYESNCQKDSDNAYIKAVFDLSYLANLRLRCFPYH
NDTIFYLSPhgyrfrqackithEHTDKVIQQRKESMKHEKELEKIQQKRHLDFLDILLF
ARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIKEVLG
DRQTMEWEDLGKIPYTNMCIKESLRIYPPVPGVARMLRNPVTFFDGRSIPAGTLVGLSI
YAIHKNPAVWEDPEVFNPLRFTPENSANRHSHAFVPFAAGPRNCIGQNFAMNEMKIAVA
LTLNRFHLAADLENPPILIPQLVLKSKNGIHVHLNKVQ

CYP4T3     Xenopus tropicalis (Western clawed frog)
           DR860523.1 CX967683.1 DT412234.1 DR834559.1
           93% to CYP4T3v2 of Xenopus laevis (ortholog)
           best match in human = CYP4B1 55%
           note: macrosynteny between Danio and human shows CYP4T
           is related to the CYP4ABXZ locus. CYP4B may be the parent 
           gene in this cluster since it is most similar to CYP4T.
MWNTLVWQQVA
ALLCLLAVLLKATQLYLSQKRQENIFKQFPGPPRHWLLGNVDQIRRDGKDLDLLVNWTHK
NGGAFPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSISYDFLVPWIGKGLLVLTGPKWFQ
HRRLLTPGFHYDVLKPYVNLISKCTTDMLDNWEKLITKQKTVELFQHLSLMTLDSIMKCA
FSYDSNCQKDSNNAYIKAVFDLS
YVANLRLRCFPYHNDTVFYLSPhgyrfrkacrithEHTDKVIQQRKESMKLEKELEKIQQ
KRHLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQIMEWEDLGKIPYTNMCIKESLRMYPPVPGVARQLRNPVTFFDGRSV
PAGTVIGLSIYAIHKNPAVWEDPEVFNPLRFSPENSANRHSHAFLPFAAGPRNCIGQNFA
MNEMKVAVALTLNRFHLAPDLENPPIRIPQLVLKSKNGIHVHLTKVQ*

CYP4T4v1   Xenopus laevis (African clawed frog)
           SwissProt A2VD77 
           79% to CYP4T6 X. tropicalis
           78% to CYP4T6 Q6AZQ1 X. laevis
MASNLWEVLSSPGLFGNIYQFGQFAAQLCLVLLLLKAWGLFIRWKSLKDALQNFPGPPK
HWLYGHANQFRGDGTDMDRVLAWADKYPKAFPMWVGQFFANLIITNPEYAKAVFARSDP
KTPTGYNFLIPWIGKGLLVLSGDKWFQHRKLLTPGFHYDVLKPYVRLISDSTNVMLDKW
VSFSNKGETVELFHHVSLMTLDSIMKCAFSYHSNCQTDKDNSYTKAVYDLSFLAHHRAR
TFPYHNNLIYYLSPHGFLFRKACRIAHQHTGKVIKQRKTLLQNKGEFEKVKQKRHPDFL
DILLCARDENGKGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEI
REVLGEKDSFEWEHLSKIPYTTMCIKESLRLYPPVPGVSRELNKPITFYDGRSLPAGSV
IFINIFCIHRNPSVWKDPEVFDPLRFSSENSSKRHSHAFVPFAAGPRNCIGQNFAMNEL
KVAVALTLNRYELSPHLSKPPLKSPQLVLRSKNGIHVYLKKAS

CYP4T4v2   Xenopus laevis (African clawed frog)
           GenEMBL AB022672
           Satoru Yamamoto
           Clone XL-301
           98% to CYP4T4v1 (4 aa diffs)
           93% to CYP4T4 X. tropicalis, 70% identical to CYP4T3 
           submitted to nomenclature committee Oct 19, 1999
KQCAGLFCVFASHSNLCIAYEMQKPLIVTQILAGKGLLVLSGDK
WFQHRKLLTPGFHYDVLKPYVRLISDSTNVMLDKWVSFSNKGETVELFHHVSLMTLDS
IMKCAFSFHSNCQTDKDNSYTKAVYDLSFLAHHRARTFPYHNNLIYYLSPHGFLFRKA
CRIAHQHTGKVIKQRKTLLQNKGEFEKVKQKRHPDFLDILLCARDENGKGLSDEDLRA
EVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIREVLGEKDSYEWEHLSKIPY
TTMCIKESLRLYPPVPGVSRELNKPITFYDGRSLPAGSVIFINIFCIHRNPSVWKVPE
VFDPLRFSSENSSKRHSHAFVPFAAGPRNCIGQNFAMNELKVAVALTLNRYELSPDLS
KPPLKSPQLVLRSKNGIHVYLKKAS

CYP4T4    Xenopus tropicalis (Western clawed frog)
          scaffold_1:2677138-2694187
          93% to CYP4T4 X. laevis (ortholog)
MASNLWEVLSSPGLPGNIYQFGQFAALLCLILLLLKACGLFIRWKSLKDALQNFPGPPKHWLYGNANQ (0)
FRNDGTDMDRILLWANKYPKAFPLWVGQFFASLVITNPEYAKAAFARS (1)
DPKTPTGYDFLIPWI (1)
GKGLLVLSGDTWFQHRRLLTPGFHYDVLKPYAKLISDSTKVML (0)
DKWVPFSNKGEPVELFHHVSLMTLDSIMKCAFSYHSNCQTDN (2)
DNSYTKAVYDLSYLTHHRARTFPYHNNLIYYLSPHGFLFRKACRIAHQHT (1)
DKVIKQRKTLLQNKEEFEKVKQKRHPDFLDILLCAR (0)
DENGKGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIRDVLGEKESFEW (2)
EDLNKIPYTTMCIKESLRLYPPVPAVSRELNKPITFSDGRSLPA (1)
GSVIFINIFCIHRNPTVWKDPE (0)
VFDPLRFSSENSSKRHSHAFVPFAAGPR (2)
NCIGQNFAMNELKVAVALTLNRYELSPDLSKAPLKSPQLVLRSKNGIHVYLKKASY*

CYP4T5      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_8637
            78% to 4T2
508  MEITRALVVLGWSHFYQLLALFCLAIVLYKLTVLLMLKRALIRNFESFPGPPGHWLFGNILE 693 (0)
902  FKQDGNDLDKLVKFGQKYPYCFPLWFGPFVCFLNIHHPEYVKTILAST 1045 (1)
1142 EPKDDLAYSFIQNWI 1186 (1)
1291 GNGLLVSQGQKWFRHRRLLTPGFHYDVLKPYVKLMAHSTKTML 1419 (0)
1673 DKWESYAKTNKPLEVFEYVSLMTLDTILNCAFSYDSNCQTER 1798 (2)
2267 KNTYIKAVYELSNLINLRFRIFPYHNDLIFYLSPHGFRYRKACMVAHSHT 2416 (1)
2521 EEVIKKRREALKKEKELERIQAKRNLDFLDILLFAK 2638 (0)
3171 DENQQGLLDEDIRAEVDTFMFEGHDTTASGISFLLYNLACHPKHQKLCRKEIMQVLHGKDTMDW 3362 (2)
3457 EDLNKIPYTTMCIKESLRMHPPVPGISRKTTKPITFFDGRTLPA 3588 (1)
392  ESRIGTSVFGIHRNASLWENPNV 457 (1) this exon from Fugu LPC.11421.x1
     fdhwrflpenvskrsphafvpfsagpr this exon from 4T2 Dicentrarchus labrax
     NCIGQNFAMNEMKVVIAMTLLKYELLEEPTLKPKIIPRLVLRSLNGIHIKIKNANQN* 

CYP4T5     Tetraodon nigroviridis (freshwater puffer) 
           ~84% to CYP4T5 fugu (ortholog)
           lower case is from fugu
MEKTKALIELGWSQAHQLFVLFCVFVVLYKLTVLLVQKRALIQNFELFPGPPGHWLFGNVXX (0)
FKQDGNDLDKMVKFGQQYPYAFPLWFGPFVGFLNIHHPEYVKTILGST (1)
EPKDDLAYRFLQDWI (1)
GKGLLVTEGQKWFRHRRLLTPGFHYDVLKPYIKLIADSTKTML (0)
DKWENYAKTNKPFELFEYVSLMTLDSILKCAFSYDSDCQTKR (2)
kntyikavyelsnlinlrfrifpyhndlifylsphgfryrkacmvahsht (1)
eevikkrrealkkekeleriQAKRNLDFLDILLFAK (0)
DENQQGLSDEDIRAEVDTFMFEGHDTTASGISFILYNLACHPEHQKxCREEILQVLNGKDTMDW (2)
EDLSKIPYTTMCIKESLRLHPPVPGISRKTTKPITFFDGRTLPA (1)
GTRIGTSVFGIHRNATVWENPTV (2?)
NCIGQTFAMNEIKVVIAMTLKKYELMEEPTMKPKIIPRVVLRSLNGIHIRIKDVK*

CYP4T6   Xenopus laevis (African clawed frog)
         SwissProt Q6AZQ1 (revised, added lower case seq)
         91% to CYP4T6 X. tropicalis (ortholog)
MASGLWKVLSSSWLPVNVAQIGQFAILLCVVLLVLKACALYSRGRKFTAALTPFPGPPS
HWLYGHVNQFRRDGKDLDRLMVWAKKYPNAFPLWIGKFFGTLIITHPEYAKLVFGRPDP
KTSTGYSFLIPWIGKGLLVLSGDTWFQHRRLITPGFHYDVLKPYVGLISDSTKIMLDKL
DAFSNKDEPVELFQHVSLMTLDSIMKCAFSYQSNCQTDIDNDYIQAVYDLSWLTQQRIR
TFPYHSNLIYYLSPHGFRFRKACRIAHLHTDKVIGQRKKLLESKEELEKVQKKRHLDFL
DILLCAKDENGQRLSDEDIRAEVDTFMFEGHDTTSSGISWILHCMATHPEHQQKCQEEI
NEVLGERQTMEWDDLNRIPYTTMCIKESLRLYPPVPSVSRELAKPITFHDGKSLPAGIL
vslqiyaihrnpnvwkdpe
IFDPLRFSPENSSKRHSHAFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELLPDLSK
PPLKLPQLVLRSKNGIHVYLKKAS

CYP4T6     Xenopus laevis (African clawed frog)
           AB114056 SwissProt Q766Y9
           Yoshiaki Fujita and Hiroaki Ohi
           Submitted to nomenclature committee 7/1/2003
           Second of three sequences submitted
           76% to 4T3, 77% to 4T4, 72% TO 4T7 (PCR from I-helix to heme)
           94% to CYP4T6 Xenopus tropicalis, ortholog
           2 aa diffs to SwissProt Q6AZQ1 CYP4T6
TSSGISWILYCMATHPEHQQKCQEEINEVLGERQTMEWDDLGRI
PYTTMCIKESLRLYPPVPSVSRELAKPITFHDGKSLPAGILVSLQIYAIHRNPNVWKD
PEIFDPLRFSPENSSKRHSHAFVPFA

CYP4T6     Xenopus tropicalis (Western clawed frog)
           NM_001017348.2 
           55% to 4B1 human, 73% to DR860523.1 
           79% to CYP4T3 of Xenopus laevis
           Called CYP4T9 on Xenopus pages
MASTLWKALSSPWLSVNIYQIGQFVALLCVVLLLLKAYALYSRG
RRFAAALVPFPGPPAHWLYGHVNQFRRDGKDLDRLMVWVNKYPNAFPLWIGKFFGTLI
ITDPDYAKVVFGRSDPKTSTGYNFLVPWIGKGLLILSGNTWFQHRRLITPGFHYDVLK
PYVSLISDSTKIMLDELDVYSNKDESVELFQHVSLMTLDSIMKCAFSYHSNCQTDKDN
DYIQAVYDLSWLTQQRIRTFPYHSNLIYFLSPHGFRFRKACRIVHLHTDKVIGQRKKL
LESKEELEKVQKKRHLDFLDILLCSKDENGQGLSHEDLRAEVDTFMFEGHDTTSSGIS
WILYCMATHPEHQQKCREEISEALGERQTMEWDDLNRMPYTTMCIKESLRLYPPVPSV
SRELAKPITFHDGRSLPAGMLVSLQIYAIHRNPNVWKDPEIFDPLRFSPENSSKRHSH
AFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELSPDLSKPPLKQPQLVLRSKNGIH
VYLKKAS

CYP4T7    Xenopus laevis (African clawed frog)
          SwissProt A1L2K6
MASNVLFGLFPTQLYSWAASLCLLLVLYKATQLYLRRRFLLTAFSSFPGPKCHWLYGNA
LQFLQVGKELDLILKWAQVYPYGVSMWLGNFHAALFLTHPDYAKAILARQDPKDETAYK
YIVPWIGEGLLVLSGPKWFQHRRLLTPGFHYDVLKPYVTLMSNCTRVMLDKWDKLMPNE
KTVELFHHVSLMTLDTIMKCAFSYNSSCQNNRDNSYIKAVYELSYLLDQRSRFFLYHND
VIFYLSPLGFRFRRALTVAHQHTDKVIKHRKQSLMNETELDKIKQKRHLDFLDILLCAK
DENGKGLSDKDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQHKCREEIRELLGDR
ETMEWGDLGQMPYTTLCIKESIRLYPPVPTIGRRLSKPITFCDGRSLPEGTEVLTSIYA
INRSPSVWNDPEVFDPLRFSPENSDNRHSHAFVPFSAGARNCIGQNFAMNEMKVAVALT
LQRYELFPDPDNEPQVIPQVVLRSLNGIHIKIRRVEKEKNKKGM

CYP4T7     Xenopus laevis (African clawed frog)
           AB114057, SwissProt Q766Y8 
           Yoshiaki Fujita and Hiroaki Ohi
           Submitted to nomenclature committee 7/1/2003
           Third of three sequences submitted
           74% to 4T3, 71% to 4T4, 72% to 4T6 (PCR from I-helix to heme)
           1 aa diff to CYP4T7 A1L2K6
TASGISWILYCMAKYPEHQKKCREEIRELLGDRETMEWGDLGQM
PYTTLCIKESIRLYPPVPTIGRRLSKPITFCDGRSLPEGTEVLTSIYAINRSPSVWND
PEVFDPLRFSPENSDNRHSHAFVPFS

CYP4T7    Xenopus tropicalis (Western clawed frog)
          scaffold_1:2712980-2727232, 
          83% to CYP4T7 X. laevis
MASNILFGLFPAQLYSWAASLCLLLVLYKATQLYLKRRFLVAALSPFPGPKSHWLYGNAHE (0)
FFQVGKELDLILRWAQVYPYGVSMWLGNFHAALFVTHPDYAKAILGRQ (1)
EPKDDTAYKYLVPWI (1)
GKGLLVLSGPKWFQHRRLLTPGFHYDVLKQYVSLMSDCTRDML (0)
DKWDKLMPNEKSIELFHHVSLMTLDTIMKCAFSYNSSCQNNR
DNEYIKAVYELSYLVYERSSFFPYHNDVIFSLSPLGFRFRKALSIAHQHT (1)
DKVIKHRKESLINETELDKISQKRHLDFLDILLFAK (0)
KDENGKGLSDEDLRAEVDTFMFAGHDTTASGISWILYCIAKYPEHQQKCREEITELLGDRETMEW (2)
GDLGQIPYTTSCIKESLRLYPPVPIIGRRLSKSITFSDGRSLPE (1)
GSVIFINIFCIHRNPTVWKDPE (0)
VFDPLRFSSENSSKRHSHAFVPFAAGPR (2)
NCIGQNFAMNELKVAVALTLNRYELSPDLSKAPLKSPQLVLRSKNGIHVYLKKASY*

CYP4T8    Danio rerio (zebrafish)
          BC056734, NM_199216, CF943677 
          AI959112 fd24f08.y1 AI558878 fb67e05.y1
          64% to 4T5 fugu
MLLYGISPFVLSVNHVFALIFLACLLTVVKLLIVRRKGVKTMER
FPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQFAFPLWFGPSLAVLNIHHPSYAKT
ILTTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKLISDS
TKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFD
LCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQG
IVKNRRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLAC
NPEHQEKCRQEIQQALDGKDTLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPL
TFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENAANRSPHAFVPFSAG
PRFVTRSV

CYP4T9X     Xenopus tropicalis (Western clawed frog)
            DR860523.1 CX967683.1 DT412234.1 DR834559.1
            Called CYP4T8 on Xenopus pages
            93% to CYP4T3v2 of Xenopus laevis
            best match in human = 4B1 55%, possibly a 4B1 ortholog
            note: this sequence is identical to CYP4T3 X. tropicalis
MWNTLVWQQVA
ALLCLLAVLLKATQLYLSQKRQENIFKQFPGPPRHWLLGNVDQIRRDGKDLDLLVNWTHK
NGGAFPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSISYDFLVPWIGKGLLVLTGPKWFQ
HRRLLTPGFHYDVLKPYVNLISKCTTDMLDNWEKLITKQKTVELFQHLSLMTLDSIMKCA
FSYDSNCQKDSNNAYIKAVFDLS
YVANLRLRCFPYHNDTVFYLSPHGYRFRKACRITHEHTDKVIQQRKESMKLEKELEKIQQ
KRHLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQIMEWEDLGKIPYTNMCIKESLRMYPPVPGVARQLRNPVTFFDGRSV
PAGTVIGLSIYAIHKNPAVWEDPEVFNPLRFSPENSANRHSHAFLPFAAGPRNCIGQNFA
MNEMKVAVALTLNRFHLAPDLENPPIRIPQLVLKSKNGIHVHLTKVQ*

CYP4T10X    Xenopus tropicalis (Western clawed frog)
            NM_001017348.2 from refseq database
            Called CYP4T9 on Xenopus pages
            55% to 4B1 human, 73% to DR860523.1
            79% to CYP4T3 of Xenopus laevis
            this sequence is identical to CYP4T6
MASTLWKALSSPWLSVNIYQIGQFVALLCVVLLLLKAYALYSRG
RRFAAALVPFPGPPAHWLYGHVNQFRRDGKDLDRLMVWVNKYPNAFPLWIGKFFGTLI
ITDPDYAKVVFGRSDPKTSTGYNFLVPWIGKGLLILSGNTWFQHRRLITPGFHYDVLK
PYVSLISDSTKIMLDELDVYSNKDESVELFQHVSLMTLDSIMKCAFSYHSNCQTDKDN
DYIQAVYDLSWLTQQRIRTFPYHSNLIYFLSPHGFRFRKACRIVHLHTDKVIGQRKKL
LESKEELEKVQKKRHLDFLDILLCSKDENGQGLSHEDLRAEVDTFMFEGHDTTSSGIS
WILYCMATHPEHQQKCREEISEALGERQTMEWDDLNRMPYTTMCIKESLRLYPPVPSV
SRELAKPITFHDGRSLPAGMLVSLQIYAIHRNPNVWKDPEIFDPLRFSPENSSKRHSH
AFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELSPDLSKPPLKQPQLVLRSKNGIH
VYLKKAS

CYP4T11    Gobiocypris rarus (a rare minnow)
           GenEMBL EU593896 (not available yet on May 16, 2008)
           Jiayin Dai
           Submitted to nomenclature committee 4/2/2008
           87% to zebrafish CYP4T8
MQLYEIFPLNLEALSINHAFPLALLVCLVIVDRLMTMKRRGMRTMEPFPGPPAHWLFGHVKEFHQDGHDLEKIIMWCEQYPFAFPLWFGPSLSILNIHHPSYVKTILTTTEPKDDYAYKFFIPWLGDGLLVSAGQKWFRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWELYAKSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYKFRKAAGMAHNHTAEVIRKRKEVLKMEKEQGIVKNKRYLDFLDILLSARDENQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCREEILRALDGKDTLEWEDLNKIPYTTMCIKESLRLCPPVPGISRKLTKPLTFFDGRTVPEGCTIGVSIYGIHLNATVWENPYVFDPLRFLPENTAKRSPHAFVPFSAGPRKGKFFKELFPVQS

CYP4T12    medaka 
           UCSC Browser chr16:19969746-19976887  (+) strand, Oct. 2005 assembly
           68% to 4T1 zebrafish, 52% to CYP4B1 human,
           51% to CYP4A11
MFAAGLTEALFG
FQLTWLHIHVAFGALCIIVIVHKLTLLTATRKSLLRDVEAFPGPPGNWLFGH (0)
LAQDGTDLERGLKWGEQYPYAFPMWFGPSVCFLNIHHPDYAKTILTTT (1)
EPKDDLAYRFIESWI (1)
GNGLLVSKGQKWFRHRRLLTPGFHYDVLKHYVNLMSESAQVML (0)
DKWESYANTSETFELFEHVSLMTLDSILKCAFSHNSNCQREG (2)
ETNKYIKAVYELSDLISFRMRTFPYHSDLIFYLSPHGFRHRRACKVAHSHT (1)
QVIRKRKEALKEETESSRKRNLDFLDILLFAK (0)
DENQQGLSDEDIRAEVDTFMFEGHDTTASGISFILYCLASHPEHQKICRNEVMEA
LDGKDTIEW (2)
EDLNKIPYTTMCIKESLRLYPPVPGISRKLTKPITFFDGRTLPA (1)
GFKVGTSVFGIHRNATVWENPE (0)
VFDPLRFLPENVSKRSPHAFVPFSAGAR (2)
NCIGQNFAMNEMKVVIAMTLKKYQLIEEPSLKPRIIPRLVLRSLNGIHIKIKPVEAQK*

CYP4T13P    medaka 
            UCSC Browser  chr16:19947384-19950469 (+) strand, Oct. 2005 assembly
            missing some parts, 95% to CYP4T12 medaka, upstream by 19 kb
MFAAGLTEALFG
FQLTWLHIHVAFGALCLIVIVHKLTLLTATRKSLLRDVEAFPGPPGNWLFGH (0)
PTQDTTNLERGLKWGEQYPYAFPMWFGPSVCFLNIHHPDYAKTILTTT (1)
EPKDDFGYMFIESWI (1)
GNGLLVSKGQKWFRHRRLLTPGFHYDVLKHYVNLMSESAQVML (0)
(missing 5 exons)
GFKVRTSVFGIHRNATVWENPE (0)
FDPLRFLPENVSKRSPHAFVPFSAGAR (2)
(seq gap)

CYP4T14    Lancelet (Branchiostoma floridae)
           UCSC Browser chrUn: 340141881-340149534 March 2006 assembly
           55% to 4T1 zebrafish, 54% to 4T12 medaka
           gene order: KIF2A CYP4T14 PTCH1 MKNK1
MTPFMNFCLLILSTTTMGSIPAQWLPHWEA
GYLRTACLTVLVAVAVQLVFRFLRALLWKRYIQKVLAPFPGQPAHWLFGHMRE (0)
VRPDETGFTIVPQWAAKFKFAFPLWIGPFRVVLSLVHPDYIKEINSP (1)
VNDLHTILSIFFTEPKDRVSYAWLKPWI (1)
GDGLLVSEGQKWFRNRRLLTPGFHFDVLKPYVKVFSECTNIML (0)
DRWADLAPGTPVEMFHYASAMTLDSLMRCALSVRSDCQRDSDGSPYIRA
VYDLTKC
VVERGRFPPFHIPLIFHLSPTGFR ()
FRKACKTAHDFSDEVIRKRRTELQQQGCHQNDTANSSE
DGGKKRYLDFLDILLQAR (2)
DEDGKGLSEREIRDEVDTFMFEGHDTTASGVSWILY
NLAKHPACQDRCRAEVDAVLQGRAEVKW (2)
EDLSKLPYTTMCIKESLRMHSPVPGVTRLTTQPHTFPDGRSIPA (1)
GVSVSIGVHSLHHNIHVWGDN (0)
EFDPERFSPENSKGRSSHAFIPFSAGSR (2)
NCIGQHFAMNELKVTVALTLQRYRLELDETRPPYR
VARLITRTRDGLWLKVYPRGADN*

CYP4T15    Xenopus laevis (African clawed frog)
           EST BG018182 de66c08.x1 
           64% to CYP4T6 Xenopus laevis (African clawed frog)
           no X. tropicalis ortholog is found
IYHLVPLDRREVAIPILSMIGTSSAAGILVSLKTYAIHENPDVSKDPEIFDHLRWSPESS
CKRHSHAFVPSAAGPRKCIVQNFAMN
DMKVDGTVSLTRY

4U Subfamily

CYP4U1     Coptotermes acinaciformis (termite)
           GenEMBL AF046010
           Patrick Falckh
           C4-8_9-D

CYP4U2     Coptotermes acinaciformis (termite)
           GenEMBL AF046011
           Patrick Falckh
           C4-8_9-F 

CYP4U3     Reticulitermes flavipes (termite)
           No accession number
           Michael Scharf
           Submitted to nomenclature committee Feb. 19, 2009
           Clone name RfP4501V1 (full length)
          99% to CYP4U3v1 (only 1 aa diff)
          98% to 4U3v2 (only 2 aa diffs)
          52% to CYP4U1 Coptotermes acinaciformis (termite), 
          69% to CYP4U2 partial seq
          47% to CYP4BN6 Tribolium

CYP4U3v1    Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #1v1
            67% to 4U2 I-helix to heme, 98.1% identical to CYP4U3v2

CYP4U3v2    Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #1v2
            68% to 4U2 I-helix to heme, 98.1% identical to CYP4U3v1

CYP4U4P     Reticulitermes flavipes (termite)
            No accession number
            Michael E. Scharf 
            Submitted to nomenclature committee 10/7/05
            Clone name #8 (pseudogene)
            78% to 4U1 I-helix to heme, one stop, 2 frameshifts

4V Subfamily

CYP4V1     Oncorhynchus mykiss (rainbow trout)
           GenEMBL AF046012
           Patrick Falckh
           OM4-8_9 

CYP4V2     human
           GenEMBL AC012525 
           formerly CYP4AH1 AC012525 Homo sapiens chromosome 4
MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGR 
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEG 
ILTSSKQIDKSSMYKFLEPWLGLGLLT 
STGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIIC 
ETAMGKNIGAQSNDDSEYVRAVYR 
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSV 
IAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE 
GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV 
KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSED
YFLTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQG 
RHPYAYVPFSAGPRNCIG 
QKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER* 

CYP4V2     Pan troglodytes (chimpanzee)
           XM_001165629.2
           97% to human two short regions do not match
MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVATYARKW                      QQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVAL                      YNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILE                      DFLDIMNEQANTLVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSE                      YVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEM                      NANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTT                      AAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLF                      PSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPKNAQ                      GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILR                      
PSNGIWIKLKRRNADER

CYP4V2    Macaca mulatta (rhesus monkey)
          95% to human 4V2
MAGIWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYVRKWQQMRPIPTVARAYPLV 
GHALLMKRDGR (1)
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE (0)
VILTSSKQIDKSSMYKFLEPWLGLGLLTS (2)
TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHVNQEAFNCFVYITLCALDIIC (1)
ETAMGKNIGAQSNDDSEYVRAVYR (2)
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHAFTNN (0)
VIAERANEMNVDEDCRGDGRDSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE (0)
GHDTTAAAMNWSLYLLGSNPEVQKKVDHELDDVF (1)
GRTDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV (1)
AGYRVLKGTEAV
IIPYALHRDPRYFPNPEEFRPERFFPENAQGRHPYAYVPFSAGPRNCI (1)
GQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPTNGIWIKLKRRNADE 1551

CYP4V2      Bos taurus (cow)
            See cattle page for details
MLAPWLLSVGPKLLLWSGLC
AVSLAGATLTLNLLKMVASYARKWRQMRPVPTIGDPYPLVGHALMMKSDARDFFQQIIDFTEECR
HLPLLKLWLGPVPLVALYNAETVEVILSSSKHIEKSYMYKFLEPWLGLGLLTSTGNKW
RSRRKMLTPTFHFTILEDFLDV
MNEQANILVTKLEKHVNQEAFNCFFYVTLCTLDIICETAMGKNIGAQRNDDSEYVRAVYR
MSDSIHQRMKMPWLWLDLIFYMFKNGREHRRSLKIVHDFTNNVITERANEMKRHEEGTSN
DKEKDFPPRKTKCRAFLDLLLNVT
DDQGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGWYPEVQQKVDTELEEVFGKS
DRPVTLEDLKKLKYLDCVIKESLRLFPSVPFFARNLTEDCEVAGHKMVQGCQVIIVPYAL
GSSRDPKYFPDPE
EFKPERVFPENLKGRHTYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKRE
ELGLAGELILRPSNGIWIKLKRRNTDES*

CYP4V2    Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          Two partial sequences called CYP4V2_1 and CYP4V2_2
          Are different parts of the same gene
          Ortholog of human CYP4V2

CYP4V2    Sus scrofa (pig) 
          CB473254.1, DB791600.1 
          lower case = cow seq
    mlapwllsvgpklllwsglc
    avslagatltlnllkmvasyarkwrqmrpvptigdpyplvghalmmksdardffqqiidfteecr
    hlpllklwlgpvplvalynaetvevilssskhieksymyk FLEPWLGLGLLTST
1   GNKWRSRRKMLTPTFHFTILEDFLDVMNEQATILVTKLEKHVNQEAFNCFF 153
153 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRVSDSIHRRMKAPWLWFDFLYFMFK 329
330 DGQEYRKSLKILHNFTSNVITERASEMKRDEERSHDDKDIPPHKNKCKAFLDLLLNVTDD 509
510 KGNKLSHEDIREEVDTFMFE 557
    ghdttaaainwslyllg 
    FYPEVQKKVDNELDEVFGKSDRPATLEDLKKLKYLECVIKESLRLFPS
3   VPFFARSINEDCEIAGHKIVKDSQVIIVPYALHRDPRYFPNPEEFRPERFFPENSKGRH 179
180 SYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKREELGLAGEPILRPTNG 356
    IWIKLKRRNTDES*

CYP4V3     mouse 
           No accession number
           Yoshiaki Fujita, Hiroaki Ohi, Katsuya Kase
           Submitted to nomenclature committee July 5, 2000
           Clone name KK-1
           80% identical to 4V2 human

Cyp4v3     mouse 
           GenEMBL AB056457 28 feb 2001 81% to 4v2
MLWLWLGLSGQKLLLWGAASAVSLAGATILISIFPMLVSYARKW
QQMRSIPSVARAYPLVGHALYMKPNNAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVAL
YKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILE
NFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSNNDSE
YVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAERVKER
KAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTT
AAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVF
PSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQ
GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILR
PNNGIWIKLKRRHEDDP

Cyp4v3  rat 

CYP4V4a    Xenopus laevis (African clawed frog) 
           87% to CYP4V4 X. tropicalis, 83% to CYP4V4b X. laevis
           presumed ohnolog to CYP4V4b
MEFKGDVQPLVWMAAAVVLLTLLAFSALPPLLDYFRKWKLMRPIPGPGPNYPLVGDALF
LKPNGGDFFLQMCEFTELFRVEPLIKLWIGPIPFVIVYHADTVEPILSTSKHMDKSYAY
KFLHPWLGQGLLTSTGEKWRSRRKMITPTFHFAILSEFLEVMNEQSKVCVEKLQKHVDG
ESFNCFMDVTLCALDIISETAMGRKIQAQNNRDSEYVQAIYKMSDIIQRRQKMPWLWLD
FIYAHLKDGKEHNKNLKNLHAFTDKAILERAEELKKTEAKKGHFDSEPESEKPKKRSAF
LDMLLMATDDAGNKLSYKDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKE
LDEVFGKSDRPVTMDDLKKLRYLEAVIKEALRIYPSVPFFARTITEDCIIRGFHVPKGV
NVVIIPYALHRDPEYFPEPEVFRPERFFSENASGRNPYAYIPFSAGLRNCIGQRFALME
EKVVLSSILRNYWVEATQKREELCLLGELILRPQDGMWIKLKNRKTASSA

CYP4V4b    Xenopus laevis (African clawed frog) 
           NM_001172180
           Yoshiaki Fujita, Hiroaki Ohi, Katsuya Kase
           Submitted to nomenclature committee July 5, 2000
           Clone name XL-4
           58% identical to 4V2 human
           82% to CYP4V4 X. tropicalis
           CYP4V4b is a presumed ohnolog to CYP4V4a
MELKGDVNVLLWTAVIVVLLTLLVFSALPVLLDYVRKCKVMRLI
PGPGPNYPLVGDALLLKSDAREFFLQMCEFAEDFRSEPLLKLWIGPIPFLIVYHADTL
EPFLSTSKHVDKAYLYKFLHPWLGKGLLTSTGEKWRIRRKMITPTFHFAILSEFLEVM
NEQSNVLVEKLQKHADGESFDCFIDVTLCVLDIISETAMGRKIEAQSNKDSEYVQAIY
KMADFIQNRQTKPWLWSDSLYAYLKEGKEHNKTLNILHTFTDKAILERAEELKKMEVK
KGDSDPESEKPKKRSAFLDMLLMATDDAGNKMSYKDIREEVDTFMFEGHDTTASALNW
TLFLLGSHPEAQRQVHKELDEVFGKSDRPVTMDDLKKLRYLEAVIKESLRIFPPVPMF
GRTVTEDCTVRGFKVPKGVNIIVITYSLHRDPEYFPEPEEFRPERFFPENASGRNPYA
YIPFSAGLRNCIGQRFALMEEKVVLSSILRKYWVEATQKRDECLLVGELILRPQDGMW
IKLKNRETASSA

CYP4V4   Xenopus tropicalis (Western clawed frog)
         CX972921.1 AL876066.2 CR409635.1 DT527908.1
         scaffold_95:1665309-182117 (+) strand adjacent to CYP4V9
         best hit to CYP4V2 in ESTdb X.tropicalis
         best match in human = 4V2 62%, a 4V ortholog
         82% to CYP4V4b X. laevis, 87% to CYP4V4a X. laevis
MELGGEVHLLVWVAAAVVLLTLLALSILPALQDYVRKRRILKPIPGPGPNYPLIGDALFLKN
NGGDFFLQICEYTESYRLQPLLKVWIGTIPFIVVYHADTVEPVLSSSKHMDKAFLYKFLHPW
LGKGLLTSTGEKWRSRRKMITPTFHFAILSEFLEVMNEQSKILVEKLQTHVDGESFDCFM
DVTLCALDIISETAMGRKIQAQSNRDSEYVQAIYKMSDIIQRRQKMPWLWLDFLYAHLRD
GKEHDKNLKILHSFTDKAILERAEELKKMGEQKKEHCDSDPESDKPKKRSAFLDMLLMAT
DDAGNKMSYMDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKELDEVFGKSD
RPVTMDDLKKLRYLEAVIKESLRIYPSVPLFGRTVTEDCSIRGFHVPKGVN
VVIIPYALHRDPEYFPEPEEFRPERFFPENASGRNPYAYIPFSAGLRNCIGQRFALMEEK
VVLSSILRNYWVEASQKREELCLLGELILRPQDGMWIKLKNRETAPTA*

CYP4V5      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_485
            60% to 4V3 over 513 aa
exon 5 starts with ETAM seen in many Drosophila 4 fam. and C. elegans sequences
36037 MADLLGGFTLPLLGASVFVAALTCFTYRMLSDYLHKWFQMKPIPELEGTYPLIGNALQFKPNAG 36222 (1)
36309 DFFNQIVEYTRENYHRPLFKIWVGPVPFVVLFHPETVE (0)
36504 PVLTNAVHMEKSYSYSFLHPWLGTGLLT 36587 (2)
37012 STGPKWRRRRKMLTPTFHFSILADFLEVMNEQAEILVEKLDQQAGKGPFNCFSYVTLCALDIIC 37203 (1)
      ETAMGKKIYAQSNSESEYVKCVSK 37380 (2)
37458 MSDIISRRQRTPWFWPNFAYYSIGDGREHDSTLKVLHSFTYK (0)
37661 VITERAENVSSVESDSDSDHGRKKRQAFLDMLLKTTDEDGNKMSHRDIQEEVDTFMFR (0)
37906 GHDTTAASMNWVLHLMGSHPEAQSKVHQELQEVF (1)
38199 GESNRPITTEDLKKLKYLESVIKEALRLFPSVPFFARSLGEDCHI 38321 (1)
38530 NGFKVPKGANAVIITYALHRDPRYFPEPEEFRPERFLPENSVGRPPYAYLPFSAGLRNCI 38724 (1)
38802 GQRFALIEEKVVLASILRKFNVEACQKREELRPVGELILRPEKGIWIKLEKRKPLIPPS* 38981

CYP4V5-like fragment    Fugu rubripes (pufferfish)
                        FS:S000209 Scaffold_209 52% to 4V5
102980 DSTIAGFKVPKGHGAIYVSHAVHRDPDVFQQPDSFLPERW 103099

CYP4V5     Tetraodon nigroviridis (freshwater puffer) 
           90% TO FUGU CYP4V5 (ortholog)
MADLPGSLTLPLLGASVFVAALTCLTYWMLGEYLHKWFTMKPIPQLQGTYPLIGNALLFKPNAG (1)
DFFNQIVEYTREFSNYPLFKIWVGPVPFVVLFHPETVE (0)
PVLNNAVHMEKSYSYSFLHPWLGTGLLTS (2)
TGPKWRHRRKMLTPTFHFSILTDFLEVMNEQAEILVEKLELQAGKGPFNCFSHITLCALDIIC (1)
ETAMGKKIYAQSNSESEYVKCVYK (2)
MSDIISRRQRTPWFWPDFVYYSFGDGREHDSTLKVLHSFTYK (0)
VITERSENISCVESDRDSDHGRRKRQAFLDMLLKTTDEDGNKMSHGDIQEEVDTFMFR (0)
GHDTTAASMNWVMHLLGSHPKAQSKVHQELQEVF (1)
GESDRPTNIEDLKKLKYLECVIREALRLFPSVPFFARSLGEDCHI (1)
NGFKVPKGANAIIITYGLHRDPRYFPDPEEFRPERFLPENSVGRPPYAYLPFSAGLRNCI (1)
GQRFALMEEKVVLASILRRFTVEACQTREELRPVGELILRPEKGIWIKLEKRKPLVLSS*

CYP4V6     Balaenoptera acutorostrata (Minke whale)
           AB290012
           Iwata Hisato
           submitted to nomenclature committee 1/6/05 
           82% to CYP4V ortholog of cow and 76% to 4V2 human
MLALWLLSVGQKLLLWGGLCAVSLAGAILTLNLLRMAASYAWTW
QRMRAVPTLEGAYPFLGHALLLKPDARDFFQQMIQYTEEHRHLPLLKLWLGPIPVVFL
YNAENVEVILTSSKHIDKSYMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILE
DFLDVMNEQANILVNKLEKYVNQEAFNCFSYITLCALDIICETAMGKNIGAQSNNDSE
YVQAVYRMSDSIHQRMKMPWLWLDLLFFIFKDGWEHKRSLKILHNFTKNVITERANEM
KRHEEGRSNDKDFPPHNNKRRGFLDLLLNVTDDQGNKLSYEEIREEVDTFMFEGHDTT
AAAINLSLYLLGSYPEVQQKVDNELEEVFGRSDRPATLDDLKKLKYLECVVKESLRLF
PSVPFFARNLNEDCEVAGYKIVKGSQVIIMPYALHRDQRYFPNPEEFKPERFFPENSK
GRHSYAYVPFSAGPRNCIGQKFAMMEEKTILSCILRHFWVESNQKREELGLAGELILR
PSNGIWIKLKRRNTNES

CYP4V7    Danio rerio (zebrafish)
          See zebrafish page for seq

CYP4V7-ie6b  Danio rerio (zebrafish)
          See zebrafish page for seq

CYP4V8    Danio rerio (zebrafish)
          See zebrafish page for seq

CYP4V9      Xenopus tropicalis (Western clawed frog)
            scaffold_95:133361-146085 (+) strand adjacent to CYP4V4
            93% to CYP4V4 X. tropicalis, 90% to CYP4V4a X. laevis
            82% to CYP4V4b X. laevis
MELRGEVHLLVWVAAAVVLLTLLALSILPALQDYVRKWKLMKPIPGPGPNYPIVGDALFL
KPNGGDFFLQMCEFTESFRSEPLIKIWIGPIPFIIVYHADTVEPILSYSKHMDKAYSYKF
LHPWLGKGLLTSTGEKWRSRRKMITPTFHFAILSEFLEVMNEQSKILVEKLQKHVDGESF
NCFMDVTLCALDIISETAMGRKIQAQSNRDSEYVHAIYKMSDIIQRRQKMPWLWLDFFYA
YLKDGKEHDKNLKILHAFTDKAILERAEELKKMGEQKKEHCDSDPESDKPKKRSAFLDML
LMATDDAGNKMSYMDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKELDEVF
GKSDRPVTMDDLKKLRYLEAVIKEALRIYPSVPFFARTVTEDCSIRGFHVPKGVNVVIIP
YALHRDPEYFPEPEEFRPERFFPENASGRNPYAYIPFSAGLRNCIGQRFALMEEKVVLSS
ILRNYWVEASQKREDLCLLGDLILRPQDGMWIKLKNRETAPTA

CYP4V10v1   Cyphoma gibbosum (cowrie, gastropod mollusc)
            EU546250.1
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-1v1, formerly CYP4C49

CYP4V10v2   Cyphoma gibbosum (cowrie, gastropod mollusc)
            EU546251.1
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-1v2, one small deletion  and 
            1 aa diff compared to CYP4V10v1

CYP4V11     Orconectes limosus (crayfish)
            GenEMBL AF091117
            Chantal Dauphin-Villemant
            submitted to nomenclature committee
            this is a tentative assignment, this sequence may require its own  
            subfamily
            50% identical to 4C1 over full length, 58% identical over C-terminal
            formerly CYP4C15

CYP4V12     Penaeus setiferus (shrimp)
            GenEMBL AF072854
            Mark Snyder
            submitted to nomenclature committee
            formerly CYP4C16

CYP4V13     Haliotis rufescens (red abalone)
            GenEMBL AF072853
            Mark Snyder
            submitted to nomenclature committee
            formerly CYP4C17

CYP4V14     Homarus americanus (lobster)
            GenEMBL AF072852
            Mark Snyder
            submitted to nomenclature committee
            formerly CYP4C18

CYP4V15    Cherax quadricarinatus (crayfish)
           No accession number 
           Moshe Tom
           Submitted to nomenclature committee May 4, 2000
           Clusters with the other crayfish sequence 4C24 on trees
           formerly CYP4C29

CYP4V16    Carcinus maenas (shore crab) 
           GenEMBL AY328467
           Kim Rewitz
           submitted to nomenclature committee 6/18/2003
           59.5% to 4C15
           formerly CYP4C39

CYP4V17   Litopenaeus vannamei (Pacific white shrimp)
          No accession number
          Shirley Chan
          Submitted to nomenclature committee August 29, 2006
          58% to 4C39 shore crab, 64% to 4C32 Daphnia, 62% to 4C31 Daphnia, 
          49% to 4C25 Anopheles, 48% to 4C53 Daphnia, 47% to 4C3 Drosophila
          Clone name Lv03
          formerly CYP4C54

CYP4V18   Litopenaeus vannamei (Pacific white shrimp)
          GU969106
          Xichao Xia
          Submitted to nomenclature committee June 10, 2010
          71% to CYP4V16 Carcinus maenas (shore crab)
          62% to CYP4V17 Litopenaeus vannamei (Pacific white shrimp)
          This seq is not named correctly in Genbank. It is called CYP4C39.
          This was due to the strong similarity to the old CYP4C39 that is now
          named CYP4V16.

CYP4V19   Fenneropenaeus chinensis (fleshy prawn)
          GenEMBL ACZ48687
          Zhe Zhang
          Submitted to nomenclature committee Oct. 28, 2010
          58% to CYP4V16, 58% to CYP4V11

CYP4V20   Macrobrachium nipponense (fresh water shrimp)
          GenEMBL JN704302
          Wenfeng Wang
          Submitted to nomenclature committee July 4, 2011
          65% to CYP4V16 crab

CYP4V21    Orconectes limosus (crayfish)
           no accession number
           C. Dauphin-Villemant, M. Tom, M. Waterman and D. Bšcking
           submited to nomenclature committee 6/15/99
           formerly CYP4C24, 86% to CYP4V18

4W Subfamily

CYP4W1     Boophilus microplus (cattle tick)
           no accession number
           Crampton AL, Baxter GD, Barker SC
           Identification and characterisation of a cytochrome P450 gene and
           processed pseudogene from an arachnid: the cattle tick, Boophilus 
           microplus.
           Insect Biochem Mol Biol 29, 377-84 1999

CYP4W2           Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W2-de10b11b  Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W3           Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W4           Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W5           Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W6           Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W7           Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)

4X Subfamily

CYP4X1     human
           GenEMBL BC028102
           David Bell
           submitted to nomenclature committee 12/30/97 revised 4/12/00
           about 50% identical to CYP4A members
           R56515, R53456, AA652746, AC026935
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQK
FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP
LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE
VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK
LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDES
GSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSIT
WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP
AVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV
TPDPTRPLTFPNHFILKPKNGMYLHLKKL

CYP4X1     Pan troglodytes (chimpanzee)
           XM_001162991.2
           99% (2 aa diffs) to human
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLR                      PFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTL                      LSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYVEVMAHSV                      KMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFE                      LSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQD                      NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLAL                      NPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPL                      TFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAG                      SRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLSEC

CYP4X1      Bos taurus (cow)
            See cattle page for details
24776 MESSWLETHWARPFYLTLVFCLALGLLQAIKLYLQRQRLLRDLRLFPSPPTHWLYGHSK 24600
4386 LFKDGKMEILEKIVEKYPCAFPRWIGPFQAFLYIYDPDYAKTFLSRT (1)
DPKSNFLYKFMTASV
1563 GKGLVNLSGPKWSQHRRLLTPGFHFNTLKSFVEVMAQSVNIML 1435
NKWEKICGSQNTLLDIYEHINLMTLDVLMKCIFSWETNCQTDSSHDNYVKATSEGSNILMQR
LFNYFYHYDLIFKLSPLGHRLREVNKILHHHTDKIVKNRRNSLKDENKQTNTQKRKYRDF
LDIVLSAQAENDSFTDADLWSEVNTFMVAGHD 
SVSAGISWLLYHLALYPEHQEKCREEIRAILGDGSSITWDQLSEM
SYTTMCIKESLRLAPPAVSISRQLSKPITFPDGRSLPAGMTVVLSIWGLHHNPAVWENPE
VFDPLRFSQECNKRHSHAYLPFSSGPRNCIGQNFAIAEIKVIVALI
LLRFQMRVEPTKPV
VFVPYIFIKPKKGIYLHLKKLP*

CYP4X1    Sus scrofa (pig)
          DB802053.1 DB802658.1 
MESSWLETHWARPLHLALVFCLALGLLQAVKLYLQRQRLLRDLRPFPSPPSHWFYGHQKI
IQNGGMETLGEITDKYPRAFPFWLGPFQAFFFIYDPDYAKTLLSRPDPKSNFLYKFMDPV
VGKGLLNLNGPKWFQHRRLLTPGLHLNALKSHVEIMAHSVNTMLGKWERICGTEDTLLEI
SAHVTLLTLDIIMKCVFGLETNCQINSTYDHYVKAVNEGSNLIFYRVYNFLYHHDIIFKF
SPKGHRFLELRKILHPYTAKIIQAGKNSLMNENQQGNTQKRKY
RNIFDIALSAQAENGDSFSDTDLRSEVNTFLLAGHETMTGGLT
WLLYHLALYPEHQERCREEIRSILGDGSSITWGQLGEMSYTTMCIKESLRLAPPVLSFSR
ELSKPITFSDGRSLPAGITVVCSIWGLHHNPAIWENPQVFDPLRFSQENNDKRHCYAYLP
FSAGPRNCVGQQFAMAELKAAVALILLRFSLTAEATRPLVSRPNIFLKPKNGLYLHLKKLP*

CYP4X1    Canis familaris (dog)
          XM_539622.2 
          74% to CYP4X1 human
MESSWLETRWARPLYLAFAFCLALGLLQAIKLYLRRLRLLRDLC
PFPAPPTHWFYGHQKLLQDGKIEKLEELVEKYPCAFPYWVGPFQAFFYIYDPDYAKTF
LGRTDPKSKYLYKFLIPCLGNGLVNLEGSKWFQHRCLLTPGFNVNILKSYIKVMAHSV
NTMLGKWEKICGTQDTVVEVFEHINLMTLDVLMKCAFSQETNCQISSNHDLYVKTTFE
ASKINFYRLYSFLHHHDIIFKFSPQGHRLQELVKILHQYTEKVIQDRKKLLKDEKKHG
NTQKRKDQDYLDIILSAQAENGNSFSDTDLRSEVNTFILAGHDTMAGSISWLLYHLAL
NPEHQERCRQEIRGILRDRSSITWDQLGEMSYTTMCIKESLRLAPPIPSISRELSKPI
TFPDGRSLPAGITVVLSIWGLHHNSAIWENPKVFDPLRFSQENSDQRHTHSFLPFSAG
PRNCIGQHFAMVKLKVAIALILLHFKVSPDPTRPLVFLHQIVLKPKNGVHLHLKKLP

Cyp4x1     mouse 
           No accession number
           Berthold Gottgens
           Approx. 410 amino acids covered with some missing parts
           66% identical to 4X1 human

Cyp4x1     mouse
           GenEMBL AJ297131 runs from 112000 to 138000 on the minus strand
           NT_039264.1, NT_039685.1
MEASWLETRWARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQK
FLQEDNMETLDEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLSRT
GRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVML
DKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQIN 
STYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYT 
EKIIQDRKKILKNQVKQDDTQTSQIFLDIVLSAQ 
GKEDERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITW
EQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTLPDGHSLPAG 
MTVVLSIWGLHHNPAVWNDPK 
VFDPLRFTKENSDQRHPCAFLPFSSGP 
RNCIGQQFAMLELKVAIALILLHFQVAPDLTRPPAFSSHTVLRPKHGIYLHLKKL

CYP4X1     rat
           no accession number
           Johan Bylund and David R. Harder
           submitted to nomenclature committee 9/26/01 
           91% identical to CYP4X1 mouse, 69% to 4X1 human

4Y Subfamily

CYP4Y1     Mytilus galloprovincialis (blue mussel)
           no accession number 
           Mark Snyder
           submitted to nomenclature committee

4Z Subfamily

CYP4Z1      human
            GenEMBL AY262056 AJ131016 AC026935 161971-176942 
            ESTs H21976, H21977, H25577, H25624
            Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
            Full length seq now available on genomic DNA
            52% to 4A11 52% to 4X1 
            because the sequence is the same percent identity to
            4A11 and 4X1 and this is less than 55% 
            and the sequence does not cluster with CYP4As on a tree
            the earlier name of CYP4Z1 is being resurrected.
            This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD
STLDYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
EKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV

CYP4Z1     Pan troglodytes (chimp)
           XR_023310 10 aa diffs to CYP4Z1
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLHQRRRWMIRALRLFPA PPAHWFYGHKEFYPVKEFEVYPELMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD
(gap)
EKVIQDRKESLKDKLKQDTTQKRCR DFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPGHQKRCRD EIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGI TVFINIWALHHNPDFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIEC KVAVALTLLRFELAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC

CYP4Z2P     human
            NT_004386.11|Hs1_4543 92% to 4Z1 add full length version
652145 TKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDG 651978

CYP4Z2P     human
            AL731892.5 94% to 4Z1 1 stop codon in exon 8
67693 MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPAHWFYGHKES 67514
66240 YPVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQ 66103
54555 DPKSAVSHKILESWV 54511
52843 GRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMML 52715
50555 NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD 50433 
50353 STLDYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 50198
40609 EKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKV 40502
35393 ENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSSITW 35205
27034 EHLSQMPYATMCIKECLRLYAPVVNISQLLDKPITFPDGRSLPA 26903
12988 GITVFINIWALHHNPYFWENPQ 12923
11873 VFNPLRFSRESSEKMHPYAFIPFSAG 11796
10762 PRNCIGQHFAIIGCKVAVALTLLCFELAPDYSRPPQPVRQMLLKSKNGIHVFAKKV 10595

CYP4Z2P     human
            AK097373 mRNA 15-JUL-2002
            breast, tumor tissue cDNA to mRNA
42  MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYRRRRWTIRAMHLFPAPPAHWFYGHKES 221
222 YPVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQDPKSAVSHKILESW 401
402 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAQNSRLELF 581
582 QHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS 761
762 SQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKSENTKD 935
936 FSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSSITWEH 1115
1116LSQMPYATMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGL 1247

4AA Subfamily

Cyp4aa1    Drosophila melanogaster
           AC004516, AC004304, AC005556, AC004426
           This sequence was called CYP47 initially, but trees with the C-terminal 
           Sequence clearly place it in the 4 family.  Since all the letters of the 
           alphabet have been used, I have had to start using double letters to 
           indicate the subfamily.  This will permit naming 576 subfamilies with 
           double letters and 24 with single letters for a total of 600 subfamiles.  
           I don't think we will ever need that many.
           35% to 4D2 35% to 4C1

Cyp4aa1    Drosophila melanogaster
           GenEMBL AC020355 comp(15477-16779) and AC007579 comp(38212-38842)

MHLRLLSPPQLERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPF
LGNCMLVTDKDLMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVF
FYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV
GTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLL
DGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRD
FTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMT
DLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIY
PDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPV
TGKTTIAATFRITLRASGGLWVRLKERDHPLIAH

Cyp4aa1     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4AA1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPi2r2

CYP4AA1-de7b8b  Anopheles gambiae (malaria mosquito)

CYP4AA1     Lutzomyia longipalpis Jacobina (phlebotomine sandfly)
            GenEMBL AM096652 AM096653 AM096654 AM096655
            63% to anoph. 4AA1, 62% to Drosophila 4AA1
4    FLKLLHNFLGNGLITSSGDKWNVHRKLIQPSFHLNILEKFIGTFNDSSQCLLDKFKSVEG  183
184  EVNITDFVNNCVLDILNEAVLGVPVFREDKEKEKSPFRQGKVVMPYRVTRPWLLLNWVY  360
361  KLTDTAASELNQKKQLDNFTRKMIHIRREAKRTGNLGERKCLLDYLIDISDQVPDFTEDD  540
541  IINEACTFMLAGQDSVGAAVAFSFFMLAQNPDCQKKCIEEIDNIFDGDTRAPTMRDLRE  717
718  MRYLEQCIKETLRLYPSVPLLARRLGEDIRVGEHTLIAGSHIFIVPYAIHRLPYIYPDPE  897
     KFDPDRFLPEEVEKRNPYAFLPFSAGPRNCIGHKFAILEMKTVISKILR  379
378  HFTLHPVEGKEDLHPSFRVTLRATVGLWIKLQRRDKV  268

CYP4AA1    Apis mellifera (honeybee) 
           48% to Drosophila Cyp4aa1 (ortholog)
MGKVSSSLTSIYILYILRTYIRSIIYISQLNGPKTIPIIGNANSILKEN (1)
FLYRLAYESQMYGRIVRIWLTIFPYVMFLEPEDIQLILNNAKHTQKVFFYKLLDNFLGKGL
ITRDIKSWRIHRRLLQPAFHLHVLEKFTNTFAKHADHLMNKILEKNNQEINITTFINDSVYNILS (1)
ETVLGINRINRINEMDDLPFRK (2)
GQIMLLYRMIRPWLLIEWIYRLTKYGREEEKQRKNLFDTCFKMVKEKRDLLQSKDRISNNDIKKNK
NISLLEYMVEINEKNPCFSDEDIVEECCTFMLAGQDSVGTATAMTIFLLANHPEWQNKCIEEIDEI
FNGDTRFPTISDLKEMKCLEMCIKESLRLYPSVPIIGRTLGEDIKI (1)
GKHIIPAGCSVLISPYSTHHLPHHFPDPDTFKPERFNSENSEKRHPYAYIPFSAGPRNCI (1)
GYKFAMLEMKSIISAILRKCRLQSIPGKKEIRPKFRMTIRAQGGLWVKIIERDQILKSIAA*

CYP4AA1    Linepithema humile (argentine ant)
           No accession number

CYP4AA1    Atta cephalotes (leafcutter ant)
           See Atta cephalotes page
           79% to CYP4AA1 Linepithema humile

CYP4AA1    Tribolium castaneum (red flour beetle)
           GenEMBL XP_973810 AAJJ01000447.1
           44% to CYP4aa1 Drosophila, 37% to CYP4BN8
           41% to 4aa1 bee, 43% to 4aa1 Anopheles
MWTDICTYLVILAVMLMSIYFKNYIRSVYLAFQLSGPPAVPLIGNVL
LMKNDRSKYQFFRGHILS (1?)
EMYSPFMRCWLSIFPVFFIYEPKALQLIMGTNRYTSKNIFYNCLHNVVGDGLITSS (1)
GEIWKQHRKLIQPYFHISVLKVYFDIFYKWS 
41760 MAMVQDLENETEVNITKYANKFVFD (0)
SQYWAFLGKDQSRLLIGGNLVQHIHQ (1)
CQFLMLHRITRPWLLFNTIFKRTDFSKVEENQKNILQQYTKS (0)
41348 ILDGKKQNSHGTAMNNLMEMMMEISNMNPEFTDDDIVNETCTFMLA (0)
41162 GQDSVGAALSFALYSLAAHQDIQEKVVQELNGIFKDGNQAATFEDVAEMKYLEQCIKETLRLYPSVPM
ITRKITEDVPL 40926 (1)
GKYTLPTGTNIVISPFVTHRLPHVFPDPLKFDPDRFS
PENKAKIHPYGFIPFSAGPRNCI (1)
GYKFAIIELKTVLSQILRKYHVSLVPGREKLILSYRMTLKAKKGIWLRLKKRSV*

CYP4AA1     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            40% to CYP4AA1 D. pseudoobscura
            39% to CYP4AA1 Anopheles gambiae
            38% to CYP4AA1 Tribolium

CYP4AA1     Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 17, 2007
            50% to 4AA1 Apis, 45% to 4aa1 Drosophila probable ortholog

CYP4AA1    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AA1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-1 and P-4-9 
           65% to CYP4AA1 Tribolium castaneum (aa 260-317 with intron)
           This piece and P-4-1 are missing about 9 amino acids between them.
           63% to CYP4AA1 Tribolium castaneum (aa 327-482), C-terminal

CYP4AB1     Solenopsis invicta (fire ant)
            GenEMBL AY345970
            Nannan Liu
            submitted to nomenclature committee 8/16/99
            51% to 4Q2 and 4M4
MPRQHLINLLFSLCDKYYPIFRTWAFFEGFVSIRHPDDLEVILN
SSTNIEKSRIYSVLHPWFGLGLLTSGGSKWHSRRKILTPTFHFNILQQFVEILIEEGE
SMTNSLKNAGSTITKDLVPLISEHTLNAICETAMGTSLQGMNSVQQEYRKAVHRMGEL
FIYRLVRHWLISDWIFALTSQGREQVKILKILHGFTNKIIAERKDYHKRTNGQYLKNF
NQSIITDNEEIVGSKKKRLAMLDFLIYASQEGHLTDVDIREEVDTFMFEGHDTTSTSL
CYTLALLAENKDIQDRVRQEVDLVMQENEGKLTIKSLQNLQYLERCIKESLRLYPSVY
FISRITTEEAQLKSHLIPVGTIMHLHIYGVHRDPNFWPNPDVFDPDRFLPENSRNRHP
YSYIPFSAGPRNCIGQRFAMLEMKAMIAPLIHNFCLEPVDLLKNLRVGPDLVLRPLGG
HRIKFIPIATKCI

CYP4AB2     Solenopsis invicta (red imported fireant)
            GenEMBL AY345971
            Nannan Liu
            submitted to nomenclature committee 9/24/02
            43% to 4C1 and 43% to 4M7 71% to CYP4AB1
            Note: formerly named CYP4AS1 by mistake
MFIALLLIIIVVYLMCHCYAQYGPNGRLINKIPGPPGYPIIGNL
FNLLESREQFWETLSILNEQYYPIYKLRAFFNSLVFIRHPDDLEIILNNTKHISKSNL
YDALRPWLGMGLLTSGGSKWHLRRKILTPTFHFNILQQFVEILIEEGESMTRSLKNAG
GTITKDLVPFISEYTLNAICETAMGTSLQEMGSFQQQYRKAVHRMGELLVYRAMRPWL
KYDWIFSLTSKGREQKKLLKILHGFTEKVIAKRKDYHKRTKGQYLKNLNKDVVPNETE
TIGIKKKRFAMLDLLIQASQEGLLTDFDIREEVDTFMFEGFDTTGMAMCFILSLLAEH
KDIQDCVRKEIDAVMQENQGKLNMKSLQDLQYLERCIKEALRLYPSVYFISRITSEET
ELKTYLIPAGTLVILNFYITHRDSNFWPNPEVFDPDRFLPDNIRNRHPYSYLPFSAGP
RNCIGQRFALLELKAMLVPLIYNFYLEPVDYLENQRFGIDMILRSLDPCRLKFVPIAT
EGI

CYP4AB3     Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.5748 (1270-4633)
            50% to CYP4AB2 fire ant
            formerly CYP4AZ1
            renamed to recognize a large hymenopteran clade
            N-term extended to match other CYP4AB seqs.
MISAILFFIFLLATLHYFLLHHRKFGKMINLIPGPEPLPILGNIPTFHNISP (1)
SELWKFLTQLSKQYYPIYRMWTFLEAYVHICHPDDIE (0)
TILGNIKFTKKGFGYKYLKPWFNTGLLTSS (1)
GHKWHVRRKILTSAFHFNVLRQFVDIFIEDAERLIKTLESEEGIFVENLLQLTSEHTLNVIC (1)
ETAMGTSLKNKEKFQYEYRKAVYNMGCIFANR(2)
IVKPWFYYDFFFNLSPEGWQQSKLLKILHNFTRK(0)
IIQERKEYHDKTNGRYLNDFHENINENDNNNDYND(1)
FRRKRLAMLDLLIEAHRNNKIDDEGIREEVDTFMFR(0)
GHDTTAISFCFSIMLLAEHKEIQ(0)
DRARAEIKAAIEENGGKLNITVLQNLPYLERCIKESLRLFPSVPRISRKLETSVKL (1)
SNYEIPSNTIINVNIFDTHRDPKFWPNPNKFDPDRFLPENSKKRHPYAYVPFSAGPRNCI (1)
GQRFAMLELKTYLGLLLYNYYFEPIDYLKDVTFVSGIVLRLENPVRMKFIPVKKIC*

CYP4AB4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB6    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB7    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB8    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB9    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB10   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB11   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB11-de7b8b10b11b Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB12   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB13   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB14   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB15   Nasonia vitripennis (jewel wasp)
           GE363597 EST
           See wasp page

CYP4AB16   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB16-de1b2b   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB16-de1c2c11c12c   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB17P  Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB18   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB19   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB20   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB21   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB22   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB23   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AB24     Solenopsis invicta (Lausanne fire ant)
             EE131689 EST
             N-term region of CYP4AB 
             65% to CYP4AB2
YPIIGNTIKLINLGVLRIWKYIICTSSDKYYPIWKLRSFFESLVIIRHPDDMETILN
NTKHINKSKLYDILHPWLGTGLLTSTDSKWHTRRKILTPTFHFNI

CYP4AB25     Solenopsis invicta (Lausanne fire ant)
             EE142405 EST
             46% to CYP4AB2
MFVTLLILCVSIILLYFITYYGRFRRLIGKVPSKPDLPFIGNALEFFMYS
QEKIWEAERLANKTHTIYTFWCGPIAFIATRDPDDIEKILSNTTQHLSKGYIYNLLHPWL
GTGLLTSEGAKWRKRRKILTPTFHFTILKEFVDIFTEESNRMIKYLKNIEGSNIDNLMNF
ISHHTLNAICG

CYP4AB26     Solenopsis invicta (Lausanne fire ant)
             EE148664.1 EE147029.1 
             MAY JOIN WITH 4AB24 82% TO 4AB2, 72% TO 4AB1
TLNAICETAMGI
SLQGLGSFQQQYRKAVHQMGEFIVYRLLRQWLKNDWIFSLTPRGREQAKL
LKILHGFTEKIIKERKDYHKLTNGQYLKNLNKDAVADEEIIGIRRKRLAMLDLLIQASQE
GLLTDKDIREEVDTFTFEGHDTTSSGICFTLALLAEHKDIQERVRKEIDVIMKENQEKLT
MKSLQDLQYLERCIKEALRLYPGVFFISRNTSEKVQLKSYLIPAGTLLHLNIFGVHRDPK
FWPNPEVFDPDRFLPDNIRNRHPYSYLPFSAGPRNCIGQRFALLELKAMLVPLIYNFYL
EPVDYLENQRFGIDMILRSLDPCRLKFAPIATEGI*

CYP4AB27     Solenopsis invicta (Lausanne fire ant)
             EE134101 EST
             70% to CYP4AB2
DGDHSTGSKWQSRRRLLTPIFHFNALQQFTEILIEEGESMANSLKNAADTITKDLV
PFISEHTLNAICEAVVGISPQKMGSFQHQYWTAVYRINEFIIYR

CYP4AB28    Linepithema humile (argentine ant)
            No accession number

CYP4AB29    Linepithema humile (argentine ant)
            No accession number

CYP4AB30    Linepithema humile (argentine ant)
            No accession number

CYP4AB31    Linepithema humile (argentine ant)
            No accession number

CYP4AB32    Linepithema humile (argentine ant)
            No accession number

CYP4AB33    Linepithema humile (argentine ant)
            No accession number

CYP4AB34Pv1 Linepithema humile (argentine ant)
            No accession number

CYP4AB34Pv2 Linepithema humile (argentine ant)
            No accession number

CYP4AB35P   Linepithema humile (argentine ant)
            No accession number

CYP4AB36    Linepithema humile (argentine ant)
            No accession number

CYP4AB37P   Linepithema humile (argentine ant)
            No accession number

CYP4AB38    Linepithema humile (argentine ant)
            No accession number

CYP4AB39P   Linepithema humile (argentine ant)
            No accession number

CYP4AB40    Linepithema humile (argentine ant)
            No accession number

CYP4AB41P   Linepithema humile (argentine ant)
            No accession number

CYP4AB42    Linepithema humile (argentine ant)
            No accession number

CYP4AB43P   Linepithema humile (argentine ant)
            No accession number

CYP4AB44   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           61% to CYP4AB2 Solenopsis invicta

CYP4AB45   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           55% to CYP4AB1 Solenopsis invicta

CYP4AB46   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           61% to CYP4AB1 Solenopsis invicta

CYP4AB47   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

CYP4AB48   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           56% to CYP4AB1 Solenopsis invicta

CYP4AB49   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

CYP4AB50   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           61% to CYP4AB1 Solenopsis invicta

CYP4AB51   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           46% to CYP4AB25 Solenopsis invicta (N-term only)

CYP4AB52   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           58% to CYP4AB1 Solenopsis invicta

CYP4AB53   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           65% to CYP4AB30 Linepithema humile

CYP4AB54P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           63% to CYP4AB32 Linepithema humile

CYP4AB55P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           71% to CYP4AB1 Solenopsis invicta

CYP4AB56   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           56% to CYP4AB1 Solenopsis invicta

CYP4AB57   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

CYP4AB58P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           53% to CYP4AB36 Linepithema humile

CYP4AB59P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           34% to CYP340F1 Bombyx mori (may be a false positive)
           upstream from CYP4AB60

CYP4AB60   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

CYP4AB61   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

CYP4AB61-ie4b Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           53% to CYP4AB27 Solenopsis invicta

CYP4AB62P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           60% to CYP4AB26 Solenopsis invicta

CYP4AB63P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

CYP4AB64P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           56% to CYP4AB1 Solenopsis invicta

CYP4AB65P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           42% to CYP4AB32 Linepithema humile

CYP4AB66P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           51% to CYP4AB2 Solenopsis invicta

CYP4AB67P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           50% to CYP4AB2 Solenopsis invicta

CYP4AB67-ie6b  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           68% to CYP4AB26 Solenopsis invicta

CYP4AB68   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           62% to CYP4AB1 Solenopsis invicta

CYP4AB69   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           60% to CYP4AB1 Solenopsis invicta

CYP4AB70   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP4AB1 Solenopsis invicta

Cyp4ac1     Drosophila melanogaster
            GenEMBL AC017771 comp(24745-26507)

Cyp4ac1     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4ac2     Drosophila melanogaster
            GenEMBL AC017771 comp(22220-24109)

Cyp4ac2     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp4ac3     Drosophila melanogaster
            GenEMBL AC017771 comp(20241-21996)

CYP4AC4     Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            54% to Cyp4ac1 Drosophila melanogaster

Cyp4ad1     Drosophila melanogaster
            AC020402 comp(36565-39829)

Cyp4ad1     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4AD1     Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            67% to CYP4AD1 D. pseudoobscura
            clone name 1196

Cyp4ae1     Drosophila melanogaster
            GenEMBL AL009194 16210-17867
            Old Cyp4e4 renamed

Cyp4ae1     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP4AE2     Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP4AE 
            59% to 4AE1 (148 aa)

Cyp4af1x    discontinued name see Cyp4ad1

CYP4AG1X    discontinued number assigned to sea bass 4F7 seq due to 
            An error at the C-terminal of this sequence (see 4F7 above)

CYP4AH1X    discontinued name see CYP4V2 human

CYP4AJ1     Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
            GenEMBL AF243506
            Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
            Insecticide Resistance Associated Cytochrome P450 Gene Fragments
            from D. v. virgifera
            Unpublished
            DvP450-1 

CYP4AK1     Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
            GenEMBL AF257100
            Isolation of family 4 cytochrome P450 gene fragments from
            insecticide-resistant and -susceptible western corn rootworms
            Unpublished 
            DvP450-3

CYP4AL1     Mytilus edulis planulatus (Australasian version of common mussel)
            No accession number
            Karl Herron
            46% to 4T4 from Xenopus, 38% to 4Y1 from blue mussel, 
            39% to abalone 4C17
            submitted to nomenclature committee Jan. 30, 2001
            I-helix to heme region

CYP4AM1     Plebidonax deltoides (Pipi or Goolwa cockle, a type of clam)
            No accession number
            Karl Herron
            48% to 4T4 Xenopus 48% to 4A20 
            partial seq. from I-helix to heme
            submitted to nomenclature committee Oct. 9, 2001

CYP4AN1    Daphnia pulex (Daphnia, water flea)
           BQ703378 EST
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.3 205 aa
           53% to 4B1 52% to 4V2 54% to 4v3 53% to 4W1 93% to 4AN2

CYP4AN2    Daphnia pulex (Daphnia, water flea)
           BQ703379 EST
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.3 prime 209 aa
           57% to 4C17 55% to 4C18 93% to 4AN1

CYP4AN3X   Daphnia pulex (Daphnia, water flea)
           BQ703375 EST
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.1 149 aa
           58% to 4v3 mouse 59% to 4c24 66% to 4AN2
           renamed CYP4BY5v2 based on genomic full seq

CYP4AN4    Daphnia pulex (Daphnia, water flea)

CYP4AN5    Daphnia pulex (Daphnia, water flea)

CYP4AN6    Daphnia pulex (Daphnia, water flea)

CYP4AN7    Daphnia pulex (Daphnia, water flea)

CYP4AN8    Daphnia pulex (Daphnia, water flea)

CYP4AN9    Daphnia pulex (Daphnia, water flea)

CYP4AN10   Daphnia pulex (Daphnia, water flea)

CYP4AN11   Daphnia pulex (Daphnia, water flea)

CYP4AP1    Daphnia pulex (Daphnia, water flea)
           BQ703376 EST
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.2 197 aa
           49% to 4V2 50% to 37A1 51% to 4C21 74% to 4AP2

CYP4AP2    Daphnia pulex (Daphnia, water flea)
           BQ703377 EST
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.2 prime 187 aa
           49% to 4V2 47% to 4C1 51% to 4C21 74% to 4AP1

CYP4AP3    Daphnia pulex (Daphnia, water flea)

CYP4AP4    Daphnia pulex (Daphnia, water flea)

CYP4AP5    Daphnia pulex (Daphnia, water flea)

CYP4AP6    Daphnia pulex (Daphnia, water flea)

CYP4AP7    Daphnia pulex (Daphnia, water flea)

CYP4AP8    Daphnia pulex (Daphnia, water flea)

CYP4AQ1X    Anopheles gambiae (mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            57% to 4H9 fragment (from Anopheles albimanus) 
            but 44% to 4H24 so new 4 subfamily related to 4H
            same seq as CYP4H26 above

CYP4AR1     Anopheles gambiae (mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            41% to 4D2 lower to other 4Ds

CYP4AR1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPe2r2
            Note very similar to CYP4K2 (almost in the same subfamily)

CYP4AR2     Aedes aegypti (yellow fever mosquito)

CYP4AR3    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 11
           70% to CYP4AR2 Aedes, 45% to 4AR1 Anoph.

CYP4AR3    Culex pipiens

CYP4AR4    Culex pipiens

CYP4AS1X    Solenopsis invicta (red imported fireant) renamed CYP4AB2
            No accession number
            Nannan Liu
            submitted to nomenclature committee 9/24/02
            43% to 4C1 and 43% to 4M7 71% to CYP4AB1

CYP4AT1     Capitella capitata (polychaete worm)
            No accession number 
            Bo Li
            submitted to nomenclature committee 2/3/2004
            Most similar to CYP4T and CYP4F

CYP4AU1     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            Sequence #14 HaCypZ014a-v3Pep revised from earlier seq.
            51% to 4M4 235aa fragment from C-term

CYP4AU1     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH000052 4 aa diffs to CYP4AU1 of Grubor in the C-term part
            53% TO CYP4AU2, 38% to CYP341A3, 36% to CYP4G25

CYP4AU2    Bombyx mori (silkworm)
           No accession number
           See silkworm page for details

CYP4AU3    Heliconius erato (red postman or red passion flower butterfly)
           GenEMBL EST EL596754.1
           N-term 51% to CYP4AU2
MFVAVLICLFCCLYYLHFRRKRKQLYEFSKSI
PSVGNLPVVGHSHWFIGGPEKILKNIQTLAQMIEDSGGISSIWLGPTLYVVTMNPEDVQK
ILENSLQKDFSYKFLQEWLGNGLFVAPVDLWKVHRRLLLPVFHNRIIEDYIDVFGEQGSV
LVKRMGEKVGKSEFDVFPYITSCMLDIVFETAMGEKMDVQHNPDTPYLRARNTVISI

CYP4AU3     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            74% to CYP4AU1 Helicoverpa armigera

CYP4AU4    Heliothis virescens
           GR960305
LSHKEGRKDILQLLLERKLAFSNIELREHIDSITIAGNDTTTLVISYALVLLGDHQDAQD
KVYKELQEIFGDSKRTPTKEDLTKMEYLERVIKETMRLYAVVPIIARTTQKELKLSTCTI
PAGVGCVVVPMVLHRSKKLWGPDADCFDPDRFLPENSVDRHPCAYIPFSHGTRNCIGRHF
GMLAMKSILATFLRTYKVSSKIPDRLKIEILLFPVDGHQITIEKRL*

CYP4AU5     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            74% to CYP4AU2 Bombyx mori

CYP4AU6    Plutella xylostella 
           Gene number CCG0015762.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           69% to CYP4AU1 Helicoverpa armigera
           missing the correct C-term

CYP4AV1     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.2000
            41% to CYP4C3 Drosophila.

CYP4AV2     Apocrypta bakeri (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 25, 2007
            65% to CYP4AV1 Apis, 82% to CYP4AV3, 81% to CYP4AV4

CYP4AV3     Philotrypesis sp (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 25, 2007
            Philotrypesis sp4
            68% to CYP4AV1 Apis, 97% to CYP4AV4, 82% to CYP4AV2

CYP4AV4     Philotrypesis sp (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 25, 2007
            Philotrypesis sp5
            66% to CYP4AV1 Apis, 97% to CYP4AV3, 81% to CYP4AV2

CYP4AV5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4AV6    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4AV7     Linepithema humile (argentine ant)
            No accession number

CYP4AV8    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           80% to CYP4AV7 Linepithema humile

CYP4AW1    Phyllopertha diversa (scarab beetle)
           GenEMBL AY605086.1
           Maibeche-Coisne,M., Nikonov,A.A., Ishida,Y., Jacquin-Joly,E. and
           Leal,W.S.
           Pheromone anosmia in a scarab beetle induced by in vivo inhibition
           of a pheromone-degrading enzyme
           Proc. Natl. Acad. Sci. U.S.A. 101 (31), 11459-11464 (2004)
           Submitted to nomenclature committee Nov. 4, 2003
           Clone name Cyp4Pd1
           41% to CYP4C1 40% to CYP4D2
           61% to CYP4W2

CYP4AW2    Phyllopertha diversa (scarab beetle)
           GenEMBL AY605087.1
           Maibeche-Coisne,M., Nikonov,A.A., Ishida,Y., Jacquin-Joly,E. and
           Leal,W.S.
           Pheromone anosmia in a scarab beetle induced by in vivo inhibition
           of a pheromone-degrading enzyme
           Proc. Natl. Acad. Sci. U.S.A. 101 (31), 11459-11464 (2004)
           Submitted to nomenclature committee Nov. 4, 2003
           Clone name Cyp4Pd2
           42% to CYP4C1 42% to CYP4D2
           61% to CYP4W2

CYP4AX1    Bombyx mori (silkworm)
           BAAB01092965.1 BAAB01135526.1 BAAB01183645.1
           50% to CYP4S4
           See silkworm page for sequence

CYP4AX2    Bombyx mori (silkworm)
           BAAB01152933.1 BAAB01194854.1 BAAB01058563.1 
           BAAB01102208.1 BAAB01008375.1
           94% to CYP4AX1
           See silkworm page for sequence

CYP4AY1    Ips paraconfusus (a bark beetle, California fivespined ips) 
           No accession number 
           Dezene Huber
           Submitted to nomenclature committee Nov. 10, 2004
           38% to CYP4AW1 from scarab beetle p= e-88
           40% to CYP4S3 p= e-77, better percent match but poorer p value.

CYP4AY2     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            56% to 4AY1, full length

CYP4AZ1X    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.5748 (1270-4633)
            50% to CYP4AB2 fire ant
            renamed CYP4AB3 to recognize a large hymenopteran clade

CYP4BA1X    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_49183273 (824-692) partial seq. 
            52% to CYP4AA1
            name changed to CYP4AA1 (ortholog)

CYP4BB1     Nereis virens (annelid polychaete worm, clamworm, sandworm)
            GenEMBL AY453407.1 (partial seq)
            Rewitz KF, Kjellerup C, Jorgensen A, Petersen C, Andersen O. 
            Identification of two Nereis virens (Annelida: Polychaeta)
            cytochromes P450 and induction by xenobiotics.
            Comp Biochem Physiol C Toxicol Pharmacol. 138, 89-96 2004.
            Clone name CYP4(1), CYP41 in abstract
            Submitted to nomenclature committee April 29, 2005 (full seq)
            41% to 4f15 mouse, most similar to vertebrate 4F seqs.

CYP4BB2     Perinereis nuntia (polychaete worm)
            No accession number
            Senlin Zheng
            Submitted to nomenclature committee Feb. 22, 2011
            68% to CYP4BB1

CYP4BB3     Perinereis nuntia (polychaete worm)
            No accession number
            Senlin Zheng
            Submitted to nomenclature committee Feb. 22, 2011
            69% to CYP4BB1

CYP4BB4     Perinereis aibuhitensis (polychaete worm)
            HM126463
            88% to CYP4BB3

CYP4BC1     Hypsibius dujardini (water bear, Tardigrade)
            GenEMBL CD449348, CF075894.1, CO741868.1
            David Drane
            4clan 52% to 4C3(bottom half only)
            N-term and C-term
            These ESTs are missing the middle region between
            The C-HELIX and the I-helix.  
            The ESTs are continuous across the gap region
            Like several exons have been skipped.
MFFLNVVIYFLIGFLVTRLVKIFLKYRRIASHIDK
IAGPPRLWLPVGNALQLSGNHFKFFQQIRQLAKDYREQSPTGALRLWIGPYPYVIMVKGK
AAEAVLSSYKFLEKGPDYDLVHPWLGTGLLTSTGDKWRSRRKFLTPAFLDLL

LSAKTEDGKVLDNASIREEVDTFMFEGHDTTSVAAAFAVFLLGNHQDVQQKAYEELRQIF
GDSDRAPTTEDLKNMRYLDCVLKESLRLYPSVPMITRKCNEDYKLPDSDIIIPEGSIVSI
FIFALGRDPDMFPEPDRFDPERFSDTKSARHRPFDYVPFSAGPRNCIGQKFAVMEEKTIL
STILRSYTIQSVEDPETLRIAGELITRPIDGISVKLFR

CYP4BD1     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            43% to 4AW1, full length

CYP4BD2     Ips pini (pine engraver, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            79% to 4BD1 Ips paraconfusus, 54% to CYP4BN4
            clone name EST 25A04

CYP4BD3     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Formerly CYP4BP1
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            46% to CYP4BM1 Tribolium castaneum 
            clone name EST MPB4B04
            note 79% to CYP4BD1 so the name was changed to CYP4BD3

CYP4BD4v1   Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            58% to CYP4BD2 Ips pini (pine engraver, bark beetle)
            clone name DPO1124_K13

CYP4BD4v2   Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            58% to CYP4BD2 Ips pini (pine engraver, bark beetle)
            insertion relative to other P450s
            clone name DPO1414_C01

CYP4BD5v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH2-1
            80% to CYP4BD4v1 Dendroctonus ponderosae, 
            100% to clone CYP4BD5v2 at the amino acid sequence level

CYP4BD5v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH2-2
            80% to CYP4BD4v1 Dendroctonus ponderosae, 
            100% to clone CYP4BD5v1 at the amino acid sequence level

CYP4BD5v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4A-1
            1 aa diff to CYP4BD5v4
            97% to CYP4BD5v1

CYP4BD5v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4A-2
            1 aa diff to CYP4BD5v3
            97% to CYP4BD5v1

CYP4BD6     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            78% to CYP4BD4v1 Dendroctonus ponderosae

CYP4BE1     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            45% to 4V2, 44% to 4C1 55% to 4C18 lobster 
            missing about 88 aa at N-term

CYP4BE2     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            65% to 4BE1 

CYP4BF1     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            50% to 4BE1, full length sequence
            53% to 4AN3 Daphnia from I-helix to heme

CYP4BF2     Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee Aug. 15, 2007
            59% to 4BF1 Ips paraconfusus
            I-helix to heme region

CYP4BF2     Ceratosolen solmsi martchali (Hymenoptera) fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 17, 2007
            Only two amino acid differences to Philotrypesis pilosa CYP4BF2
            In the overlapping region
            This is a clear ortholog so it has the same name
            I-helix to heme region, with some missing sequence

CYP4BG1     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            43% to 4J9 full length sequence
            52% to 4C21 from I-helix to heme

CYP4BG2v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH3-1
            60% to CYP4BG1 Ips paraconfusus
            98% to CYP4BG2v2

CYP4BG2v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH3-2
            60% to CYP4BG1 Ips paraconfusus
            98% to CYP4BG2v1

CYP4BG2v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4B-1
            97% to CYP4BG2v2
            98% to CYP4BG2v4

CYP4BG2v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4B-2
            99% to CYP4BG2v2

CYP4BG3     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            94% to CYP4BG2v4 Dendroctonus valens

CYP4BH1     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            43% to 4AW1 full length sequence

CYP4BJ1     Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            41% to 4BF1, missing sequence after heme signature

CYP4BJ2     Ceratosolen solmsi martchali (Hymenoptera) fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee July 17, 2007
            57% to CYP4BJ1
            This seq will be less than 55% identical to 4BJ1 in full length, 
            so the name may not be correct. However, the next closest match 
            is 46% so this looks like it may be an ortholog.  

CYP4BJ2     Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp, 
            No accession number
            Dong-Guang Wan
            Submitted to nomenclature committee Aug. 15, 2007
            57% to 4BJ1 Ips paraconfusus
            Only 3 amino acid differences to Ceratosolen solmsi martchali CYP4BJ2
            This is a clear ortholog so it has the same name
            I-helix to heme region

CYP4BK1     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Mark Hahn,  Kristen Whalen
            Submitted to nomenclature committee Oct. 24, 2005
            Clone name 60_1_ext
            41% to 4F11, 43% to 4F6
            57% to part of CYP342A1 Nereis AY453408, but not to whole seq
            same region is 57% to CYP4F11

CYP4BK1     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-2a

CYP4BK2     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-2b

CYP4BK3    Ruditapes philippinarum (Japanese littleneck clam, mollusc)
           GenPept FJ516740.2
           55% to CYP4BK1

CYP4BK4    Meretrix meretrix (hard clam, mollusc)
           No accession number
           Hongjun Li
           Submitted to nomenclature committee April 30, 2012
           86% to CYP4BK3 Ruditapes philippinarum (Japanese littleneck clam)
           55% to CYP4BK1 

CYP4BK5    Capitella teleta (polychaeate worm, annelid)

CYP4BK6     Perinereis nuntia (polychaete worm)
            No accession number
            Eun-Ji Won
            Submitted to nomenclature committee Feb. 16, 2012
            54% to CYP4BK3, 50% to CYP4BK1
            60% to CYP4BK5 Capitella teleta
            formerly CYP4DU1

CYP4BL1v1X  Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Mark Hahn,  Kristen Whalen
            Submitted to nomenclature committee Oct. 24, 2005
            Clone name 54_4_F_ext
            52% to part of seq CYP4FA1 AF163824.1 Coscinasterias muricata 
            47% to CYP4Y1 Mytilus galloprovincialis (blue mussel) AF072855 partial 
            seq 
            Note: these old sequences have been replaced by newer versions below

CYP4BL1v2X  Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Mark Hahn,  Kristen Whalen
            Submitted to nomenclature committee Oct. 24, 2005
            Clone name 54_9_F_ext
            97% to CYP4BL1v1X probable allele
            Note: these old sequences have been replaced by newer versions below

CYP4BL1v1   Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3a1v1

CYP4BL1v2   Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3a1v2 (old CYP4BL1v1X above)

CYP4BL1v3   Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3a2

CYP4BL2     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3c possible hybrid of CYP4BL1 (N-term) 
            and 4BL3 (C-term) genes.

CYP4BL3     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b3

CYP4BL4     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b1

CYP4BL5     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b2 #1

CYP4BL6     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b2 #2

CYP4BL7     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b2 #3

CYP4BL8     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b2 #4

CYP4BL9     Cyphoma gibbosum (cowrie, gastropod mollusc)
            No accession number
            Kristen Whalen
            Submitted to nomenclature committee Feb. 4, 2008
            Clone name CYP4-3b2 #5
            possible hybrid of CYP4BL3 or CYP4BL8 (N-term) with CYP4BL1 (C-term)

CYP4BM1    Tribolium castaneum (red flour beetle)
           GenEMBL XP_966563
           poor match 42% to 4C3
MDFTYLLLFTFFTIGFVNFCKWLKDRKRIWDAIEPIGGEKWYPLIGTCLELIKTKRKDFYDVYCARNMKY
GPFFRTWMGFIPAVHVMKPDHVERILSSTVNLTKGDNYRFVVPWLGEGLITGSNHKKWRVHRKLITPTFH
FSILDNMMEVMAEKGQFLAEQLVPKANGQFFNIYPFLTLCELDIICETAMGVEVNAMKHSQSEYVRSVYG
ISDIMLYRMFHPYLHPDFVFNLSSKGRQHKKYLSILHGFTRKVIQERKEKLTSGRDVVQELSEEDKLLGK
KKRLAFLDLLLEANKNSEGGLTDEDIREEVDTFMFAGHDTSTVTVGWTLFTLSNYPEYQEKVHQELDEIF
QGEERPITPQDVLKMQYLDKVIKETQRLIPVVPVIARTLDQDLEIVASSRTIPAGVMVVIHLARLHKDPD
QFPEPDRFDPERFLPENVSKRHPYSFVPFSAGPRNCLGQKFALRNTKVLLASILRKYKVRAEKKIDEMKY
NIEIVLRPQGGLSVALEPRRR

CYP4BN1    Tribolium castaneum (red flour beetle)
           GenEMBL XP_971854
           66% to 4BN4, 48% to 4AW1, 48% to 4BH1
MGALALVVFAVTTLLFLIWFIRLVRKNNDYYKDIPGPRPLFFFGNVFEVSTTRDILNVMHKYALQFNGLY
KIHLGPVRKLIIASDYKFLECVLSSMKILNKSEDYLYLRPWLGTGLLTSDGPKWKKHRKIITPAFHFQIL
EQFVEVFESGGNRFVQQLQKEVGKKSVDIYPYVTLCTLDIICESAMGISINAQFDDNSDYVRSVKAMCRI
TMERLFHLLEMNDVTYPLTKNYYTQKKSLNVLHNQTNSVINRRRKELENKTEAINVTNEDKADNNDTLFG
RNKKAFLDLLLQATVDGRPLTQEEIREEVDTFMFEGHDTTASAISFAIYCLANNADVQAKAYEEQIALFG
GNKSPAVTYSDLQSMKYLELVIKETLRLYPSVPMFARKTSEPVQYENIFIPEGVTVNIFAYGIHRDPKYF
KDPEKFDPSRFETVDGKLPYAYIPFSAGPRNCIGQKFAMLEMKSTISKVLRNFELQPATPTHTVQLAAES
VLKSANGVKIALKNRN

CYP4BN2    Tribolium castaneum (red flour beetle)
           GenEMBL XP_971905
           72% to 4BN5 
MILPILLCLIFSFLIWSLYQTCKKNSFYKNIPGPSGVPIFGIAFEFKSTQ (1)
DVLINLTSYIKTYGDIVTAKIGPFR
86921 RYLLVSDYNFLECVLSSTKLIKKSHHYTFFQGWLGTGLLTAD (1)
GAKWKTHRRILTPAFHFQILEQ 86682
FIEVFEKCGDVLVKKFENEVGRKSFDIYPYVTLHTLDVICESIMGISVNAQNNSTSEYVNSVKNICKIFV
ERSVSPLQMCRFMYPFTKNYWAEQKALKILHQHTNSVIDARRKELHKAENGHNTNPKKSKKPFLDLLLET
KIDGIPLTQEEIREEVDTFMFEGHDTTASAISFTLYSLANNLHVQEKAVDEQKKIFGERKDVTAAYADLQ
NMKYLENIIKESLRLYPSVPFYNREITDDIMFDNKLLPKGDTIMVFAFAIHRNAKYFDNPEQFNPDRFND
LENKLPYAYIPFSAGPRNCIGQKFAMLEMKSTISKILRKYKLLPADPQHELNLVSELILKSSNGIKISIE
PRC

CYP4BN3    Tribolium castaneum (red flour beetle)
           GenEMBL XP_966858, XP_975914
           56% to 4BN1
MALLTDVFLPLVIILLIFWYWYRSQKNKKYYQNVATPPTVPILGNALDFTTTTELLGTFMRYRKDYGGLV
KVHIGPLRHFLLVSDYKMLEYLLSSPKIVDKSEDYKFLSSWLGTGLLLADGGPKWKKHRKILTPAFHFQI
LEQFVDVFDSCSNVLIQKLDKEVGNTSVDVYPFVTLFTLDVICESTMGTKINAQDDVTSDYVQSVKHMCR
IIIERSISPVQMYDFLFVFTRNYFIQRRALRILHDKADGVISQRLRELQAQTKTDSEGDSEGIKKKKAFL
DLILEAKVDGKPLSQDDIRQEVETFMFAGHDTTASAISFTLYCLANYPEVQKMAYEEQLSIFEDNNEPDV
TYANLQSMKYLELVIKETLRLYPSVPIIGRQSGEDFQF
DNSWIPKGDTMLLFLYGIHRDPKYFKDPEVFD
PNRFENPDNKMPYSYIPFSAGPRNCIGQKFAMLEMKCVLSKILRKFELQPAVPQHNLLLTAETVLKSANG
IKIGIKLRK

CYP4BN4    Tribolium castaneum (red flour beetle)
           GenEMBL XP_971963
           66% to 4BN1, 52% to 4AW1, 51% to 4BD1
MCCCFPLALAALHWPRDARVDDCRLCYPMPMRDAGQQLLQHQKLSGTLRMDTQAAAKTPTLALRHDAMQS
FNRPTFYLVLDIMMKYMKIYGGVVKFHGGPIDKTLLVSDYNFLENVLSSTKILNKTDDYKFLHSWLGTGL
LTSAGPKWKKHRRILTPAFHFKILEQFIDVFESAGNKLVKKLEKVVGKDSVDIYPFVTLCTLDIICETAM
GIKINAQDNGESEYVRSVKQMCKIIIERSFSLLQMINLTYPLTKNFYIEKNALKILHQQTNSVINQRRQE
LKNQSKNIEQENDLGTKTRKAFLDLILEATVDGRPLTDTEIREEVDTFMFEGHDTTASAISFALFCLATH
PEVQARALEEQKALFGDTKNPTPTYTDLQNMKYLEQVIKEALRLYPSVPFHGRKTNEAVEFNNGTVVPKD
VTITVFTYGIHRNPEYFKDPEKFDPSRFDTIDGKLPYSFIPFSAGPRNCIGQKFAMLELKSTLSKVVRKF
ELRPATPEHKLQLTAETVLKSVNGIKISLKLRQ

CYP4BN5    Tribolium castaneum (red flour beetle)
           GenEMBL XP_967939
           72% to 4BN2 
MITIVIILIFILVSINFITKYLKKLKQNKDFYQNIRGPRGLPILGSALDFKTTK (1)
DVLQNLINYTRDYGEVVTAQIGPFHRYILVSNYDFLECVLSSTKLSSKSHNYNFLRPWLGTGLLTSD (1)
GAKWKTHRRILTPAFHFQILEQFIEVFEKCGNTLLEKLRNEVDKETCDIYPYVTMCTLDIICESIM
GISINAQEDSTSDYVQSVKNVCRIMVERSISPLQMCPFMYPLTKNYWTEKKSLKILHKQTNDVINARRKE
LESSKEVSSYEENFTKKKKPFLDLLLETKIDNRLLTQEEIREEVDTFMFEGHDTTASAVSFTLFCLANNL
ESQQKAFEEQQAIFGNIQNVTASYTDLQNMKYLEQVIKEALRLYPSVPFYGREITENVEYDGKLLPKGDI
LLIFAFGIHRNEKYFPNPEKFDPDRFHNMDNKTPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKVLRQYKL
LPTTPQHELELVGETILKSTNGIKIRVTLRN

CYP4BN6    Tribolium castaneum (red flour beetle)
           GenEMBL AAJJ01000217.1, DT795816 = EST
           76% to 4BN1, 46% to 4d2, 50% to 4D24, 
           51% to 4AW1, 43% to 4H8
       MNIILEFFSALAVIIVLSWWYLFLKNYKVGKFFKNFSGPPGVPLLGNALDFKNKTK (1)
41530  GVLPAFLNYNKNFGGLVKVQIGPFRKLLLVSDYKFLEFVLSSTKIINKSQNYRTMLPWLGTGLLTS  41727
41728  EGIKWKKHRRIITPTFHFKILEQFINSFDAAGDVMINKLRKKVGIESVDIYPFVTLCALD  41907
41908  IIC (1) 41916
41969  ETAMGTTINAQNNEESEYVTSVKEMGRIIIERAIAPQKNNEFLFRFTKDY  42118
42119  QLQKSALKVLHNYTNNVISKRREELLKDQASKVSENVIDMGIKKKMAFLDLLLQATVDGR  42298
42299  PLTNEEIREEVDTFMFE (0)
       GHDTTASGISFALYCLANNPEAQEKAYEEQVALFGKEKKPIVSYSDLQEMKYLELVIKEALRLYP
       SVPFYARETNQEVEFGDI  42696
42697  KIPKGVNITIFAYGIHRDPKYFPEPDKFDPGRFETIDGKLPYAYIPFSAGPRNCI  (1) 42861
42915  GQKFAMLEMKSTISKVLRNFKLCPATPHHTLDLVAETVLKSDNGVRLSLMERQ*  43076

CYP4BN7     Tribolium castaneum (red flour beetle)
            GenEMBL XP_972577
            66% to CYP4BN8
MYLIAIVIVLISLYLIVKPVKKTGNIDDFPEPPSKVFFGHALDAKSTTEILNVTTNYVKKYGKIVKLRLG
PFFKALVVTDYKLVEFFLSSNSLLTKSQNYAFARSWLGNGLILANGTHWKQHRKILTPAFHLEILREYLE
TFDSVGRIFIEKLKSLDNVQSVDLDALVPLCTLDVICETAMGTKINAQKGENSEYVSSVKEMCRIIVARF
LSPLKILKCTYWMTHDFYTERKVVNILHSFTSKVIDGRKTNRNETEKSGKKKAFLDLLLKFSDIEKLSDR
DIREEVDTFMFAGHDTTATGVCFALYLLANNPEVQEKVLSEQKELFGDEKNPCVTYQELQNMKYLEYVIK
ETLRLYPSVPVIGRYLKEDTTFGDRVISAKTNVAIFIYGIHRNPDYFPEPEKFIPERFENMTNLPPYAYI
PFSAGPRNCIGQKFAMLEMKSLISKVIRHFELTPANPHHELVLAAETVLKSANGIKIGLRARSENKM

CYP4BN8     Tribolium castaneum (red flour beetle)
            GenEMBL XP_972624, AAJJ01005264.1
            66% to CYP4BN7, 55% to 4BN4
MFIFAALFFLIIFYLYHQNVKLNRILCTFPEPPKKFLLGHVLDITSTT (1)
DVLNVFSK YINNYGPTIKLRAATLFAGLGTTDYKLCELLLSNNRILSKSLNYQYAR
NWLGNGLLISDGDYWRRHRKILTPAFHFEILKQFVETFESVGKVFVEKLDISQGPSVDLPPLVTLCTLDV
ICETAMGTQINAQKGQNAKYVQSVREMCRILIDRGLSPLKILNNTYWMTKDYYIEKKSLKVLHSFTSSVI
EKRKAERNERNCTKLAFLDLLLKFSNEGELLTDQELREEVDTFMFEGHDTTASSISFVLFCLANHPEVQE
KVLREQNELFGDDKDPSVTYHELQKMKYLEQVIKETLRLYPAVPIIGRCTSEDITFGEHFIPKDTNIAIY
IYGIHRNPEHFPEPETFNPDRFKNSNSLPPYAYIPFSAGPRNCIGQKFAMLEIKSIVSRVVRCFELRPAE
PYHSLVLSAETVLKSANGIKIGIRKRI

CYP4BN9     Tribolium castaneum (red flour beetle)
            GenEMBL XP_971513, AAJJ01000614.1 also has 4BN10
            66% to CYP4BN10
MIVFTGYLIAIVLILFPLYYYYAKCYALEKFYHQFPSPPKTPFFGNALDLKTTK (1)
DLFQSFHRYVKAYGT
17128 MVHLKIGPFDHMLLCSNPKFLEFLLTSNTLLKKSPNLRYLVPWIGTGVATAY (1) 16970
16925 GPKWKLHRKLVTPAFHYS
VLSQFVNTFESSGNILVEKISKLCDGQKVDNFDLYPHITRCTFDIICETAMGTKSNVQTNETSVYFESIK
EMCRIFMSRTMAVFQRYDFIFRFSKDFHLQKKALDIIHNYSNEVIATKRKELDENVKQKESVDDLGRKEK
MVFLDMILNKAIDGHIFSQEAIRGEVDTFMFAGHDTTATAISFILLCIANHNEVQDKIIEEQERLFGCEK
NPKVTFAHLQEMQFLENVIKEGLRLYTPVPLYGRQIDKNVEFEGMLIPKGVNVVIFNHGVHMNPEFYPNP
EKFDPNRFESMEDKHPFAFIPFSAGPRVCIGKKFAILEIKSILSKIVRNFELFPASPSYELDLAAETVLK
SLNGIRIGIKRRETF

CYP4BN10    Tribolium castaneum (red flour beetle)
            GenEMBL XP_971570
            66% to CYP4BN9
MSVLTEFFIALVALILLPFYFYYTKIRRIENFFKHFPSPAGVPILGVAPEFKTTSSVLDNFHKYAKAHGT
MVHLKFGPFKHALLCTDTKFLEFLLSSNKLLKKSVNLRFLEPWIGTGLVTADGGPKWKTHRKLITPAFHF
KILEQFVDIFESGGDILVKKLSEVSGSKSCDIYPYITKCTLDIICETAMGTKVDVQNTENSAYFESIKEM
CRIFTVRTVGAFLSNDFIFRFSKDYKIQTKAVKVLHNHSNEVIVNKRKELKEKNNENTSDIDELGRKKKK
VFLDLILSATTDGQSLSPEEIREEVDTFMFGGHDTTGTATSFILYCIANNKEAQEKILEEQKQLFGDERS
PKVTYSTLQEMKYLENAIKEGLRLYSPVPIYGRLIDQDTEYNGTMIPKGVGVIIFAHGIHMNPKYYPNPE
KFDPSRFENTTGKDPFTFIPFSAGPRNCIGQKYAMLEIKSLVSKVVRNFELFPASPTHEMHLAPETVLKS
LNGVKIGLKMR

CYP4BN11    Tribolium castaneum (red flour beetle)
            GenEMBL AAJJ01000275 
            53% to CYP4BN4, 49% to CYP4BN6
73454 MEILFTLFILLLCLLLYFYNKYVYIFDKNLKDYPAPPQVPILGHTLDF (0) 73597
73690 LIFLGFLDVLLSYTHKYGDIVRIRPGPIRQLLLTSNYKLFEAVLSNAKITKKSADYKFFHRWLGTG 73887
73888 LLTSDGAKWKKHRQIITPTFHFQILENFVDVFEKNGKILTKQLEKHLNEDSVNVYGFVNL 74067
74068 CALDIIC (1) 74088
74133 EAAMGTSVKAQENMNSEYVRSVKDLLDTLMGRIFSPYKMIDFIYFFTEDYKKEMKALQ 74306
74307 VIHSYTRNVIKSRQAAINSGEFEQKTKKNFLDLLLAANEQQMTLEEIREE 74456
74457 VDTFMFA (0) 74477
74527 GHDTTASTISFALFCLANHPDEQ (0) 74595
74648 ARVYREQKDIFGDDFKRAVTFQDLKKMKYLEYVIKETLRLYPVGPFFSRELDKDVPFAG 74824
74825 KVLPKGLTITLFIYAMHRNPEYFPDPEKFNPSRFETFDGKMPFAFVPFGAGPRNCL (1) 74996
75039 GQKFAMLEMLSVVSRVVRTYKILPSIPRHEINVAAQVVLISTNGMRMRFEKR 75194

CYP4BN12v1  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4D262110
            65 amino acids from heme to end
            71% to 4E2 (very short match), 64% to 4D2, 
            96% to CYP4BN12v2, 2 aa diffs
            72% to CYP4BN1, 45% to 4D22, 51% to XM_967484
            70% to XM_967484.1 PREDICTED: Tribolium castaneum 42% to 4D14

CYP4BN12v2  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4PD1553
            62 amino acids from heme to end
            68% to 4E2 short match, 61% to 4D2, 
            69% to 4BN1, 67% to CYP4BN13v1

CYP4BN12v3 Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           2 aa diffs to CYP4BN12v1

CYP4BN13v1  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4PD25180
            64 amino acids from heme to end
            57% to 4D2, 71% to 4BN3
            71% to XM_961765.1 PREDICTED: Tribolium castaneum, 
            44% to 4D22, 47% to 4D23
            56% to XM_966761.1, 52% to XM_967484

CYP4BN13v2  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4PD24810
            61 amino acids from heme to end
            54% to 4D2, 95% to CYP4BN13v1 (3 aa diffs), 68% to 4BN3

CYP4BN13v3  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4PD29346
            60 amino acids from heme to end
            56% to 4D2, 95% to CYP4BN13v1 (3 aa diffs), 71% to 4BN3

CYP4BN13v4  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4PD61109
            53 amino acids from heme to end
            52% to 4D2, 96% to CYP4BN13v1, 69% to 4BN3 
            same aa seq as CYP4BN13v3, different nucleotide seq

CYP4BN14v1  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4D215Ic4
            61 amino acids from heme to end
            63% to 4D2, 64% to 4BN1 98% to CYP4BN14v2, 1 aa diff

CYP4BN14v2  Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P4PD273ic4
            61 amino acids from heme to end
            61% to 4D2, 62% to 4BN1

CYP4BN15   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-12 
           58% to CYP4BN4 Tribolium castaneum, N-term half

CYP4BN fragment   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-5 
           56% to CYP4BN4 Tribolium castaneum C-term
           59% to CYP4BN12v1 Leptinotarsa decemlineata
           too short to name yet

CYP4BP1X    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            46% to CYP4BM1 Tribolium castaneum 
            clone name EST MPB4B04
            note 79% to CYP4BD1 so name changed to CYP4BD3

CYP4BQ1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            50% to 4AY1 full seq Ips paraconfusus
            clone name EST DPG20G05

CYP4BQ1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            1 aa diff to CYP4BQ1 of Sandstrom
            clone name DPO1017_M20

CYP4BQ1v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH1-1
            89% to CYP4BQ1 Dendroctonus ponderosae (probable ortholog)
            98% to CYP4BQ1v2

CYP4BQ1v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP4RH1-2
            89% to CYP4BQ1 Dendroctonus ponderosae (probable ortholog)
            98% to CYP4BQ1v1

CYP4BQ1v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4D-1
            100% to CYP4BQ1v4
            97% to CYP4BQ1v2 
            90% to CYP4BQ1 DPO1017_M20

CYP4BQ1v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP4D-2
            100% to CYP4BQ1v3
            97% to CYP4BQ1v2 
            90% to CYP4BQ1 DPO1017_M20

CYP4BQ2     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            54% to CYP4BQ1v3 Dendroctonus valens

CYP4BR1    Tribolium castaneum (red flour beetle)
           GenEMBL XP_966411, XP_975718 (missing an exon)
           AAJJ01002884.1
           53% to 4BR3, 45% to 4H11, 43% to 4D23,
6659 MILAIVIALISAPFIWWMLILSKYRSLSNVPGPKPSPVIGNSLHIGYRPQDLFNNIVKWAKEYGTVYKIF
VANDVRVLITNPELTELVLSSNVHITKSNAYDLLKPWLGIGLLIST GKKWKSRRKLITPTFHFKILDQFL
DVFNSCGNVLVQRLSSQVGKDSFDVYPFINLCSLDIIC ETSMGVKIKAQQGNNTEYVEAVRRFLDIFIIR
TFSVWKGIDALFKFSSAYSVYKRLLKILHQFTINIIVQRRGEKAQQKTQNVTSDDGIKRKVALLEMLLES
EDNNMLSNEDIREEIDTFMFEGHDT TTSGIAFAILCLAENPKVQEKLYEEVVAVIDNIENITMQQLQEMK
YLEMVLKEAQRLYPSV PVIERRLEVDCNIGGYDFPKDTFLSLFIYGMHHNEKYFPEPEKFDPNRYLPENQ
AKRHNYAYVPFSAGPRNCIGQKFAMLEMKTTIAKIVKHFKILPVPDYKPDLGIAAILKSYNGVCVRLQHR
HGN 8527

CYP4BR2P   Tribolium castaneum (red flour beetle)
           GenEMBL AAJJ01002884 pseudogene between 4BR1 and 4BR3
 9437 SGKKWKTRRKMITPTFHFKILDQFIEVFNSCGNVLVEKLSSHVGKESVDVYPFINLCS 9610
 9699 TKRNGIKRKVAXXX
 9737 MLLESEHNNVLSNEDIREEIDNFMIRG
 9823 HDTTAFGIAFAILALADN
 9876 PKVQDKVYGEILSVIGDYEDVTMQ*LQDSRYLEMVIKEA 9992
      GGYDFPKDTAFSTFXXXXXXXXXX 10083
10082 FPNPEKFDPNIFLPENQS 10135

CYP4BR3    Tribolium castaneum (red flour beetle)
           GenEMBL XP_967724
           53% to CYP4BR1
MFVVAFFVTLTVILCTPLIWWYLTLAKYSSLKKVPGPPPLPVIGNSNVIGKTTVDLLHSFMNLQDKYGTV
VKVWLGPRLHLLITKPEMVEFFLNSTVHLNKSDGYDLFKPWLGDGLLVSTGSKWKTRRKLITPTFHFKIL
ENFLETSFNKQINILLDVLLKEASQTDKSIEIHSLINLCSLDIICETAFGTELNAQAKCNPKYVEAVTGF
LEIFTLRFFSAWLRHPLIFRLSDKYAKYMEYLKILHDFTNTIIKRRKEEFKLLQDNAKISEEGIKRRAAL
LDMLLEVSDNGKNLTDEDIREEVDTFMFEGHDTTTTSICFVLYAIAQNPDVQKKIYDELVSVLGPDCKKE
ITFSDIQELKYLDVVIKEAHRLYPPVPLIERSLEEDCTIDGLTIPKNTNISIFLYGMNYNKDVYPEPHVF
DPDRFLPEKQGERHTFAYVPFSAGPRNCIGQKFALLELKTTIAKLLRCFEISPDPKNPPQVGMCSVLKSR
NGIHMFLKKKN

CYP4BR4     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            56% to CYP4BR3 Tribolium castaneum

CYP4BS1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-2, 49% to 4C1 cockroach, 79% to CYP4BS2
            Pediculus genome site

CYP4BS2     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-3, 48% to 4C1 cockroach, 79% to CYP4BS1
            Pediculus genome site

CYP4BS3     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-4i, 71% to CYP4BS1
            Pediculus genome site

CYP4BT1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-5, 42% to CYP4C3
            Pediculus genome site

CYP4BU1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-6, 42% to 4C1 cockroach, 52% to CYP4BU2
            Pediculus genome site

CYP4BU2     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-7, 52% to CYP4BU1, 38% to CYP4C1, 39% to 4AZ1 Apis
            Pediculus genome site

CYP4BV1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph4-8, 41% to CYP4C3
            Pediculus genome site

CYP4BW1     Ceratosolen solmsi martchali (fig wasp)
            No accesion number
            Dong-Guang Wan
            Submitted to nomenclature committee July 9, 2007
            54% to CYP4C25, 56% to CYP4C24 Orconectes limosus (crayfish)
            partial seq from I-helix to heme

CYP4BW2     Ceratosolen solmsi martchali (fig wasp)
            No accesion number
            Dong-Guang Wan
            Submitted to nomenclature committee July 9, 2007
            95% to CYP4BW1, 55% to CYP4C24 Orconectes limosus (crayfish)

CYP4BW3    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4BW4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4BW5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4BW6    Linepithema humile (argentine ant)
           No accession number

CYP4BW7    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           72% to CYP4BW6 Linepithema humile

CYP4BW8    Solenopsis invicta (fire ant)
           EH413513 EST
           81% to CYP4BW6 Linepithema humile

CYP4BX1    Daphnia pulex (Daphnia, water flea)

CYP4BX2    Daphnia pulex (Daphnia, water flea)

CYP4BX3    Daphnia pulex (Daphnia, water flea)

CYP4BX4    Daphnia pulex (Daphnia, water flea)

CYP4BY1    Daphnia pulex (Daphnia, water flea)

CYP4BY2    Daphnia pulex (Daphnia, water flea)

CYP4BY3    Daphnia pulex (Daphnia, water flea)

CYP4BY4    Daphnia pulex (Daphnia, water flea)

CYP4BY5v1  Daphnia pulex (Daphnia, water flea)

CYP4BY5v2  Daphnia pulex (Daphnia, water flea)
           BQ703375 EST
           Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
           Submitted to nomenclature committee Feb. 27, 2002
           Clone name 2.1 149 aa
           58% to 4v3 mouse 59% to 4c24 66% to 4AN2
           formerly CYP4AN3
           renamed based on genomic full seq

CYP4BY6    Daphnia pulex (Daphnia, water flea)

CYP4BZ1    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4BZ2    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4CA1    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP4CB1    Liposcelis bostrychophila (psocid)
           EU979550 
           Jiang Hongbo
           Submitted to nomenclature committee Feb. 20, 2009
           36% to CYP4C3 Droso., 37% to CYP4C37, 38% TO 4C61, 37% TO 4C62
           40% TO EU979551, 41% TO EU979549, 37% TO 4BM1 Tribolium
MLGLLILLVIIFALVIGLDYYNHYKDPRRIIDRIFPGPFRIPIVGNALIAACSREAFYRVYLNLSKSYDYKPFRLWFLKQPYVFISDYENTKKILSSNDLLDKAEDYRYFEPWLGQGLLTSKGDKWRRDRKIITPAFHFQILHRFFQIFYDNGEIFCEKLTAHDGGDVFDVFEYIEMLTLDNLCNAALKLDIQAQLNPFSALVCAIQNMGVVIYNRIFTLWLRYDAMFRLSSTARLQKKCLEIIHGNDVKIIRERKEEMKTKQPKLKTMEFDEKEKVAFLDLLLEMQDDVGYTDEDIREQLDTFMFAGHDTVTATLGFLIYSLAEHPDVQEKVYRELLDIYGESERCPNFSDLQDMKYTEQVIKETLRLYTVVTAVARRVEEDFELSEHQVVPKGVEIVLLLSALHRNPEIFPNPDIFDPDRFSPEVNQERDSFAFVPFSAGSRNCIGQKFAMHEMKITVYKIVKKFKLSISDKPEDKVRTRTGVVLSSTNGIRIKVQSRKKKTPSKLADQ

CYP4CC1    Liposcelis bostrychophila (psocid)
           EU979549 
           Jiang Hongbo
           Submitted to nomenclature committee Feb. 20, 2009
           39% to CYP4D22, 43% to CYP4D2, 40% TO 4C62, 39% TO CYP4C61
           44% TO CYP4CD1, 41% TO CYP4CB1, 41% TO CYP4BN1 TRIBOLIUM
MIFYVIVTTILLLLYIKYRLTIRHLVVVDTMFPGPTCLPIIGNALMLRGTSEDFYKRFTETCFYYRRSFRVWIAHRLFIACLYPEDAEVILGNNFEITKADVYEFLLPWIGDGLITSTGKKWRTHRKMLTPAFHFRILEEFTKVFNKNGKIFCEVLSKIPENKIFDVYEYVKMYAMDNICETAMSVSINAQKNPNSAYIRAVKDMCTVAFKRMRTLWLRSDFLFRMSPWAKVHDDALSLIHSQTRDVIKKRKQELERNPDLRLTMENDNFSIKGKLAFLDILLHAAQEYRLTDEDIREEVDTFMFEGHDTITSAISFAMYYISRDQEVQKKILQETESIFRGEDREPTVKDFGAMKYLETVIKETLRLHPSVPFIARKISQDFQIDMKAYAPRGAEVLVVIAALHRNPYQWEKWDQFYPEHFLPEATQKRHPYSFVPFSAGPRNCIGQKFAMIEMKSVLSKVVKEFELIPSPHPEHAIREVPDLILTSGTGMHVGLRKRISGAA

CYP4CD1    Liposcelis bostrychophila (psocid)
           EU979551 
           Jiang Hongbo
           Submitted to nomenclature committee Feb. 20, 2009
           47% TO CYP4BN6 TRIBOLIUM, 
           42% to 4D17, 43% to 4D2, 41% to CYP4C62, 39% to 4C61 
           44% TO CYP4CC1, 40% TO CYP4CB1
MVLHGLFVTFVCATLIYVLERIIHRRVYKAEKQFDGPPGYWFFGNSFDFINKSSKEIFDQVVENLKTYGNGRFYKIRIMHRLGIACSDHRDMEVILGSNTLIDKGVHYHFILPWIGFGPLTSNGSRWRKHRKIITPTFHFKILEQFIDVFNKNGAIMCEKMEKEVNGEPFNVYNYVNLAALDNIFESAMGINMNVQKNSETTYVRAIKEMCNVVNKRVFWWILRIYPIFRLSKYYKMQTDALNVLHSTTVNIIEQRKKELAVRKKLEKDDEKDEEIEFYQKKRMAFLDLLLESAEASNISDEDIRQEVDTFMFEGHDTISSGLSFALWALANNPDVQQKVYEEQMEIFGDSNRPPTFNDLQNMKYLERTLKESQRLFPSVPMITRKLNEDVDLPGGYHLPKGTNVGMIIYSLHRDPKVWPNPEKFDPDNFTPDAIQGRNPYSYVPFSAGPRNCIGQKFAMLEMKSTVSKVVRQYKLLPSPYEKHKLQLTSELVLMSLSGVHVKIQRRSNSFS

CYP4CE1    Nilaparvata lugens (Homoptera: Delphacidae)
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee April 13, 2009
           clone name: BPH4-8
           38% to CYP4AZ1 honeybee, 42% to Cyp4c3 Drosophila
           43% to Nilaparvata lugens CYP4C61, 41% to Nilaparvata lugens CYP4C62

CYP4CE2    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           87% to CYP4CE1 Nilaparvata lugens

CYP4CF1    Panonychus citri (citrus red mite) 
           FJ480404
           47% to CYP4V2 human

CYP4CF2    Tetranychus urticae (two-spotted spider mite, arachnid)

CYP4CG1    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           Confidential, formerly CYP4M3 (fragment)

CYP4CG2    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4CG3    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP4CG4     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            54% to CYP4CG1 Manduca sexta

CYP4CG5     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            55% to CYP4CG1 Manduca sexta

CYP4CG6     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            49% to CYP4CG1 Manduca sexta

CYP4CG7     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            49% to CYP4CG1 Manduca sexta

CYP4CG8     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            74% to CYP4CG6 Heliconius melpomene

CYP4CG9     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            74% to CYP4CG11 Heliconius melpomene

CYP4CG10    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            74% to CYP4CG9 Heliconius melpomene

CYP4CG11    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            74% to CYP4CG9 Heliconius melpomene

CYP4CG12    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            84% to CYP4CG11 Heliconius melpomene

CYP4CG13    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            47% to CYP4CG1 Manduca sexta

CYP4CH1    Acyrthosiphon pisum (pea aphid)
           LOC100167623p SCAFFOLD15279:22883..50385 (- strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           70% to LOC100163721
           small duplication near C-term
           CYP4 clan
MWYLTVITPIAILVVIIMILRLEGRRKRVLANKIPGPDGSIFIGMLPLFLQGPEQLILKGLKVYQKYEKSLFKVWVLNNLYIVLTRPEDIEMVLTNPKLQKKSKEYLVLQESIMGQGIFSIDDIKKWKSNRKMVSGGFNFTIIKSFIPIFYEESNVLNDILKQKCDLKSNECDISVPVSMATMEMIGKTALGVKFNAQNGGRHRFVENLQTAMHAWEYRISHP
WYLSKTLFQLSSVKKKHDQSQKIINEFTDEIINKKLDELNQNANN
KNKVETDDEDVCRKTKTVIEILLGNYHEMSHEQIRDELVTIMI
GGQETTAMANACAIFMLAHHPDVQNKVFEELQSIFSTGDHNRPPTYEDLQQMEYLERVIKETLRIFPPLPVFGRSLEEEMKIGEHLCPAGSTLMVSPLFVHSSGQYYTDPEKFNPDNFLPDTCRGRHPYSFIPFSAGYRNCIGIKYG
ILQMKTVISTLVRK
NTFSPSERCPTPKHLRVMFLSTLKFVDGCYVKIVPRTS*

CYP4CH2    Acyrthosiphon pisum (pea aphid)
           LOC100167777p   SCAFFOLD9588:3006..11080 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           30% to CYP4G7
           missing N-term, might be a pseudogene
           CYP4 clan
YEKSMFKAWLFNKLYIVLTRPEDIEFVLASPKFLRKAKEYMVLQQSIMGQGIFTIEDINKWKINR (2?)
XXXXXXXXXXXXXXXXXXXXXXXXVLAEILGD NSDSTSKECDISVPVSMATMEMIGKTALGVTFNAQKGGCNRFVENLLTAMHAWEYRITHPWYLSSTLFQFSSIKQKHDHSQKIINEFTDEIIKSKIVEINNSGSENGVNADDDDIGRNTKTLTKIFLENPHENMTLEQIRDELVTVMIGGQETTAMANACVVFMLAHHQDVQDKVFKEQESIFSIGDRNRPITYNDLLQMEYLERVIKETLRLFPPLPVFGRDLNEDTTIGDHLCPAGSTLIICPLFLHSSPQHYGSTAHGPDAFDPDNFLPEACHERHAYAYIPFSTGPRNCIGIKYAMLQMKTVASTLVRHHRFLPSDRCPTPDQLRLVFLTTLKLADGCYVKVEPRRPQ

CYP4CH3    Acyrthosiphon pisum (pea aphid)
           LOC100163721  SCAFFOLD9588:25696..30352 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           revised middle
           70% to LOC100167623p, downstream of LOC100167777p
           CYP4 clan
MXXXXXXXXXXXXXXXXXILVITIVILILKGRKNRILANRIPGPNGWFLVGMLPLFLQGPEKLIKNILREYRIYEKHIVKFWLFNNLYIVLTRHQDIELVLGNPKFLRKSKDYMVLQESIMGQGIFSIDDIEKWKNNR
KMVMKGFNFTPTKSFIPIFYQEAN
VLAEILQEKCVLKSNECNISGPVSMATMEMIGKTALGVTFNAQTGGCNQFVEHLQTAMHAWEYRVTHP
PWYLNNTLFRFSSVKREHDRSQKIINKLTDEIIKQKIIELSQNINNS
EKKIESDNEECCQKSKTVLEILLGSSHKMDHEQIRDEIVTVMI (1)
GGQETTAMAITCTIFMLAHHQDVQNKVFEELQSIFVNGDRNVPPTYKDFQQMKYVEMVIKETLRLFPPLPFLGRRLDEDMKIGEYMCPAGAALIICPIFVQSSPLYYTDSEKFNPDNFLPDACGSRHSYAYIPFGAGLRNCIGIKYAMLQIKTVISTLVRK IKFSPSERCPTPEDLRLMFLMTLKLVDGCYIKMEPRT 

CYP4CJ1    Acyrthosiphon pisum (pea aphid)
           LOC100166760.pro   SCAFFOLD7010:99236..111631 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP4 clan
MIFSNVIGALTSDSNTQWMALLSLVVLGVYFLFSDRFSENRGRQISLLPSITRSQWTSLILSLKLASFGPRDILPYFDNVIKKYGSLIHLKIIARHYIIINDPDDIKVLLSSVQHITKGPDYEMLEPWLNKGLLTSTDQKWHSRRKLLTNTFHFKILETYVPSLNKHSRSLVKNLINASDNGKSIADIDSHVTLCALDIVCETIMGVNLRTQEGKSMNYVKAIKNVSQILIKRIFTFWYWNEIVFNLSSIGREFRKSLKLLHDFTENVIRERRKILENVEQKKVDENGKKRIYSFLDLLVGVSKENPGAMTDKDIREEVDTFLFEGHDTSSIAITMAIIHLGLDQNIQNLVRDELYEIFGDSDRDATMEDLKAMTNLERVIKETMRLYPSVTGITRTLKQPLHLDKYTIPSKSVMVVVPHLLHRDKNIYPNPEKFDPDRFLPEQCNGRHPYAYIPFSAGPRNCIGQKFAMYQMKTVLSTILRYTNVETLGTQKSIVISTQLILRADYLPSGVRDFPVKSFSLV 

CYP4CJ2    Acyrthosiphon pisum (pea aphid)
           LOC100164743.pro    SCAFFOLD7010:120446..129462 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           adjacent to LOC100166760.pro
           CYP4 clan
MLETNVYNFVLIPLAILISYAIWSRLRKPLEYRQISSHVPSVTKNLWSELLFSCSIAMKHPRDLLPFFMEIFLNNGPVVHCNITGRSYVLLNDPDDIKILLSSTQYINKGPEYKMLKPWLNDGLLLSSGLKWQNRRKLLTNTFHFKTLDMYNPAVNKHAKVFTKKLLEACEDDKEISVMEYVTLCSLDIICETIMGTEMNAQKGKSIQYVYSIKSACRSVIDRVFKFWLWNDLIYRISESGRSFFKSIRVLHDFTDSVIKRKQSLLKTSGNTIVQPESKPAEKRKTKSFLDLLLDVLKDNPDQMTIKDIREEVDTFLFEGHDTSSISMTMTLLLLGMHQDIQDRAREELHSIFGDSDRDATMEDLNAMRYLDAVIKESLRLYPSVPSFTRELETTLQLENYKIPPMTTMVIFPYILHRNENIFPKPEDFIPERFLDEDNKSKFLFGYIPFSAGARNCIGQKYAMNQMKTVVSTVLRNAKIVSSGCKEDIKISMQLLIRIESLPKVIFRPL 

CYP4CJ3    Acyrthosiphon pisum (pea aphid)
           LOC100162661.pro  SCAFFOLD7010:131616..139794 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           41% to CYP4C3 adjacent to LOC100164743.pro
           CYP4 clan
MIEVNFYSVVLVPLAGLISYAIWSRLRMPVEYRQISSHVPSVTKSFWSEMVLSWKLAMLQPK
DILPFVTDLFKENGPVVHFNLSGRSYVLLNDPDDLKVLLSNTQYIKKGPEYEMLKPWLNEGLLLSSGQKWHNRRKLLTNTFHFKTLDMYNPSINKHSRILVDKLFEASANDDKEISIAEYVTLCSLDIICETIMGTEMNAQKGKSAEYVHSIKSACKSVIERIFKFWLWNDLVFRMSGSGQSFFKSIKILHEYTDNVIKSKRASLNNSGIEKIRSDSKFEKTKKKSFLDLLLNVLNDTPDQMSDRDIREEVDTFLFEGHDTSSIAMTMILVLLGMHPEIQDRARDELRSIFGYSTRDATMEDLNAMKYLEAVIKESLRMYPSVPAFTRELDKPLQLNKYIIPPMTTITVYPFILHRNEDIYPDAEEFIPERFLDEENKAKFIFGYLPFSAGARNCIGQKYAMNQMKIVVSTILRNAKFESLGRKEDIQISTQLIIRIESLPKMKFYKL

CYP4CJ4    Acyrthosiphon pisum (pea aphid)
           LOC100160629  SCAFFOLD7010:141476..155172 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           adjacent to LOC100162661.pro
           CYP4 clan
MIEVNFYSVVLMPLAGLISYAIWSRLRMPVEYRQISSHVPSATKTFWSEMVLSWKLAMMQPK
DILPFLTDLIRNNGPVVHFNLSGRSYVLLNDPDDLKILLSNTQNIKKGPEYEMLKPWLNEGLLLSSGQKWHNRRKLLTNTFHFKTLDMYNHSINKHSRILVDKLLDASANSNKEISIADYVTLCSLDIICETIMGTEMNAQEGKSVQYVHSIKCACKSVIERIFKFWLWNDLIYKISGSGQSFFKSIKALHEFTDNVIKSKRALLNNSGIEEMQSDKKTKKKSFLDLLLNVLNDTPDQMNDRDIREEVDTFLFEGHDTSSISMTMTLVLLGMYPDIQDRARDELHSIFGDSDRNATMEDLNAMKYVEAVIKESLRLYPSVPGITRELQTPLQLKNYIIPPMTTIAVYPFILHRSENIYPNAEEFIPERFLDEENKAKFQFGYLPFSAGARNCIGQKYAMNQMKIVVSTILRNAKFESLGSKEDIQISTQLVLRIESLPKMKFFNL*

CYP4CJ5    Acyrthosiphon pisum (pea aphid)
           AUG5s3079g1t1    SCAFFOLD3079:13926..21110 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           64% to LOC100166760.pro
           43% to CYP4CE1, 43% to 4V16, 42% to 4C1
           missing the N-term
           CYP4 clan
DVLPFLSSILKQHGSLVHIHLLGHSYVLLNDPNDIKVLLSSPQHINKGPEYGLLKPWLNKGLLTSGSQKWQMRRKLLTYTFHFKILETYISSFNKHAQCLTKKLENMASNNQRVSIYTHMTLCALDLVCDTIMGTELRSQEGKSLEYVEAINTVTDITIKRIFKFWLWNGSIFNLSQIGRDFNKSLKILHTFTENVIKEKRAKLESVNCLETEELSFGKKRVESFLDLLIGISKQNPEKMTDMDIREEVDTFLFEGHDTSSTAMTMAFIQLGLNQDIQNSVREELYSIFGDSDREATMADLKSMTYLDRVIKETIRLYPSVPSVTRMLRQHLHIKEYDIPPQTVVVVVPYLLHREEKHFPNPLTFDPDRFLPEHSINRHPYAFIPFSAGPRNCIGQKFAMYQMKTIISTVIRKMKIETLGSQDDIKISAQLILRPESLPDIKLTKIK 

CYP4CK1    Acyrthosiphon pisum (pea aphid)
           LOC100161405.pro   SCAFFOLD15733:160611..183325 (- strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           47% to CYP4BT1 Pediculus humanus
           CYP4 clan
MNYHDHLTTRSRHCTTTVEEINDVERDDYNRSPLPLSTSGILIRTVEPILATVSLVFDKSFILFACFSKFSLQYFNELYLFLCQLLVDLHFFRLLLEWHSKFGDTYQLWIGLRPFIAMANADHIQQILKSTVHIDKNLEYNLLLPFIGTGLVTSSGSKWHTRRKLLSPTFHQNILEGFLPLIEKQMKTLVKVLRKEVNNVNGFDIKPYAKLAALDTIGNTAMGCEINSQENSQLDYVKALDELTAIMQKRFITPWLKPNLLFNLTSLSKRQKACIDVIHTFTRKVIKERKDNFKLFNNQTSDANKNEIHYEKKPNRALLDLLIEVSEDGKVLSDEDIQEEVDTFMFAGVDTTSVTLSWVMYVLGKHPHVQDKIVEELNQKIPNFGDGNLTLNILSSLDYLGRTIKEVLRLYPSVPFIGRQIYQPLTIGDHTILPGTSIFINVFALHRNEKHFENPEKFDPDRFLKEKKNDRHRFAFVPFSAGSRNCIGQKFAMIVLKIAVATVIKTYRVKSIDPEEKLGLVGEIVLNALNGIHVTLEERT 

CYP4CL1    Tetranychus urticae (two-spotted spider mite, arachnid)

CYP4CL2    Panonychus citri (citrus red mite)
           JQ690089
           Tian-bo Ding
           Submitted to nomenclature committee Feb. 26, 2012
           94% to CYP4CL1

CYP4CM1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig11893 491aa 
           47% TO CYP4CJ1 aphid, in the CYP4 clan

CYP4CN1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig6889 501aa 
           40% TO CYP4BR1 Tribolium, in the CYP4 clan

CYP4CP1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig7689 509aa 
           43% TO CYP4D23, in the CYP4 clan

CYP4CQ1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig3337 502aa 
           40% TO CYP4D24, in the CYP4 clan

CYP4CR1    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4CS1    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4CS2    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           52% to CYP4CS1 Trialeurodes vaporariorum (whitefly)

CYP4CS3    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           58% to CYP4CS1 Trialeurodes vaporariorum (whitefly)

CYP4CS4    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           60% to CYP4CS1 Trialeurodes vaporariorum (whitefly)

CYP4CS5    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           54% to CYP4CS1 Trialeurodes vaporariorum (whitefly)

CYP4CT1    Trialeurodes vaporariorum (whitefly)
           confidential

CYP4CU1    Ummeliata insecticeps (spider)
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee March 27, 2010
           45% to CYP4C55 Daphnia pulex
           first spider P450
           confidential

CYP4CV1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            46% to CYP4BM1 Tribolium castaneum (red flour beetle)
            clone name DPO0110_J19

CYP4CV2     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            76% to CYP4CV1 Dendroctonus ponderosae

CYP4CW1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP4 clan
           Clone name P-4-2 
           41% to CYP4BR1 Tribolium castaneum (new CYP4 subfamily)

CYP4CX1    Linepithema humile (argentine ant)
           No accession number

CYP4CX2    Linepithema humile (argentine ant)
           No accession number

CYP4CX3    Linepithema humile (argentine ant)
           No accession number

CYP4CX4    Linepithema humile (argentine ant)
           No accession number

CYP4CX5    Linepithema humile (argentine ant)
           No accession number

CYP4CX6P   Linepithema humile (argentine ant)
           No accession number

CYP4CX7    Linepithema humile (argentine ant)
           No accession number

CYP4CX8    Linepithema humile (argentine ant)
           No accession number

CYP4CX9    Linepithema humile (argentine ant)
           No accession number

CYP4CX10   Linepithema humile (argentine ant)
           No accession number

CYP4CY1    Linepithema humile (argentine ant)
           No accession number

CYP4CY2    Linepithema humile (argentine ant)
           No accession number

CYP4CY3    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           64% to CYP4CY2 Linepithema humile

CYP4CZ1    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           Formerly CYP4CX1 but name conflict required a change
           46% to CYP4C7 Diploptera punctata

CYP4DA1    Diaphorina citri Kuwayama (Asian citrus psyllid)
           No accession number 
           Siddharth Tiwari
           Submitted to nomenclature committee April 7, 2011
           50% to CYP4C10 Coptotermes acinaciformis

CYP4DB1    Diaphorina citri Kuwayama (Asian citrus psyllid)
           No accession number 
           Siddharth Tiwari
           Submitted to nomenclature committee April 7, 2011
           49% to CYP4G60 whitefly

CYP4DC1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee May, 15, 2011
           40% to CYP4U3 Reticulitermes flavipes (termite)

CYP4DC1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           40% to CYP4U3 Reticulitermes flavipes
           gene 11 plus P22 make a complete sequence

CYP4DD1v1  Laodelphax striatellus (small brown planthopper)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee May, 15, 2011
           44% to CYP4C61 Nilaparvata lugens (brown planthopper)

CYP4DD1v2  Laodelphax striatellus (small brown planthopper)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee May, 15, 2011
           45% to CYP4C61 Nilaparvata lugens (brown planthopper)
           2 amino acid diffs to CYP4DD1v1

CYP4DD1v2  Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           More complete but still missing the N-term

CYP4DE1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee May, 15, 2011
           45% to CYP4C61 Nilaparvata lugens (brown planthopper)

CYP4DE1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           complete

CYP4DF1     Pogonomyrmex barbatus (seed-harvester ant)
            See Pogonomyrmex page
            Reed Johnson 
            Submitted to nomenclature committee June 3, 2010
            43% to CYP4CX9 Linepithema humile
            Formerly CYP4DC1, but name conflict

CYP4DF2     Pogonomyrmex barbatus (seed-harvester ant)
            See Pogonomyrmex page
            Reed Johnson 
            Submitted to nomenclature committee June 3, 2010
            47% to CYP4CA1 Nasonia, 77% to CYP4DF1
            Formerly CYP4DC2, but name conflict

CYP4DF3     Pogonomyrmex barbatus (seed-harvester ant)
            See Pogonomyrmex page
            Reed Johnson 
            Submitted to nomenclature committee June 3, 2010
            48% to CYP4CA1 Nasonia, 77% to CYP4DF1
            Formerly CYP4DC3, but name conflict

CYP4DG1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           47% to CYP4J18 Culex pipiens, 61% To CYP4DG2

CYP4DG2    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           44% to CYP4J18 Culex pipiens, 61% To CYP4DG2

CYP4DH1    Locusta migratoria manilensis
           No accession number
           Ren Xiaoyu
           Submitted to nomenclature committee Nov. 8, 2011
           49% to CYP4U3 Reticulitermes flavipes (termite)

CYP4DJ1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 39% to CYP4U3 Reticulitermes flavipes, 
           38% to CYP4C1 cockroach

CYP4DK1v1  Plutella xylostella 
           Gene number CCG004951.2
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           98% to CCG005621.2, 6 aa diffs in overlap
           38% to CYP4BN1 Tribolium castaneum

CYP4DK1v2  Plutella xylostella 
           Gene number CCG005621.2
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Missing N-term 89 aa

CYP4DL1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL2       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL3P      Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL4       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL4-de3b  Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL5       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DM1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DN1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DN2       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DP1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DP2       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DQ1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DR1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS2       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS3       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS4       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS5       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS6       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS7       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS8       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS9       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS10      Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DT1       Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)

CYP4DU1X    Perinereis nuntia (polychaete worm)
            No accession number
            Eun-Ji Won
            Submitted to nomenclature committee Feb. 16, 2012
            54% to CYP4BK3, 50% to CYP4BK1
            60% to CYP4BK4 Capitella teleta
            renamed CYP4BK5

CYP4DV1    Rhynchophorus ferrugineus (red palm weevil)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Jan. 26, 2012
           50% to CYP4BH1 Ips paraconfusus, 51% t0 CYP4BN6 Tribolium
           missing N-term

CYP4 fragment    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Shi Xiaoqin 
           Submitted to nomenclature committee Dec. 10, 2010 
           CYP4 clan
           Clone name seq 2
           60% to CYP4AK1 Diabrotica virgifera
           too short to name EXXR to PKG fragment

CYP4FA1  Coscinasterias muricata Australian sea star (11 armed starfish)
         GenEMBL AF163824
         Georgiades,E., Holdway,D., Wu,Q.K., Brennan,S., Butty,J. and
         Temara,A.
         The impact of oil-derived products on the biology of the
         eleven-armed asteroid Coscinasterias muricata
         Aquatic Toxicol. (1999) In press 
         partial seq. from I-helix to heme
         Given its own subfamily renamed CYP4FA1
         Old name CYP4F20

CYP4FA1  Coscinasterias muricata Australian sea star (11 armed starfish)
         No accession number
         Karl Herron
         Submitted to nomenclature committee Oct. 9, 2001
         3 aa differences with AF163824 from I-helix to heme region
         partial seq. from I-helix to heme

CYP4        Caenorhabditis elegans (nematode worm) 
            CEMSH91R
            C-terminal fragment with coding region identical to wEST00713
            CYP4 fragment. Region before translated "AGPRNCIG" may be an 
            intron sequence.
            The complete gene of this fragment is CYP29A2, probably a 4 family 
            equivalent in C. elegans.

5A Subfamily

CYP5A1      rat
            GenEMBL D28773
            Tone,Y. et al. 
            unpublished
            submitted to Nomenclature Committee

CYP5A1      rat
            GenEMBL S69335 (1849bp)
            Tone,Y., Miyata,A., Hara,S., Yukawa,S. and Tanabe,T.
            Abundant expression of thromboxane synthase in rat macrophages
            FEBS Lett. 340, 241-244 (1994)

Cyp5a1      mouse
            GenEMBL L18868 (1856bp) Swiss P36423 (533 amino acids) AC073390.1
            PIR JN0683 (533 amino acids)
            Zhang,L., Chase,M.B. and Shen,R.-F.
            Molecular cloning and expression of murine thromboxane synthase.
            Biochem. Biophys. Res. Commun. 194, 741-748 (1993)
            Note: ExxR sequence in K-helix is ETLS.  The S deviates from an 
            extremely highly conserved R at this position.
MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGI
RHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVE
NFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACE
LLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRAST
FCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRR
DFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQ
AFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPY
LDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPET
FDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPET
QVPLQLESKSALGPKNGVYIKIVSR

Cyp5a1      mouse
            GenEMBL U41326 to U41337 and U41397 (genomic sequences)
            Zhang,L. and Shen,R.-F.
            unpublished (1996)

CYP5A1      Cavia porcellus (guinea pig)
            AAD20319
  1 DMIKQVLVEN FSNFTNRMAS GLEPKPVANS ILLLRDKRWE EVRGVLTSVF SPEKLNEMIP
 61 LISQACDLLL AHLRRCAESG NACDMQRYYR AFATDVVASV AFGTRVDSQK DPEDPFVLHC
121 RRFFAFSMAR PLLVLILSFP SIMVPLARIL PNKNRDELNH FFTELXRNVI A

CYP5A1      Sus scrofa (pig)
            GenEMBL L13128 (1789bp)
            Shen,R.-F., Zhang,L., Baek,S.-J., Tai,H.-H. and Lee,K.-d.
            Porcine thromboxane synthase complementary DNA: cloning,
            expression, and sequence comparison.
            Gene 140, 261-265 (1994)

CYP5A1      human
            GenEMBL M74055 (687bp) PIR JN0074 (245 amino acids)
            Wang,L.-H., Oshashi,K. and Wu,K.K.
            Isolation of partial complementary DNA encoding human thromboxane
            synthase
            Biochem. Biophys. Res. Commun. 177, 286-291 (1991)

CYP5A1      human
            GenEMBL M80646 (1719bp) M80647 (1882bp)
            PIR A41766 (534 amino acids)
            Ohashi,K., Ruan,K.-H., Kulmacz,R.J., Wu,K.K. and Wang,L.-H.
            Primary structure of human thromboxane synthase determined from 
            the cDNA sequence.
            J. Biol. Chem. 267, 789-793 (1992)
            M08646 is truncated M08647 is functional.

CYP5A1      human
            GenEMBL S70152 (1753bp)
            Lee,K.-d., Baek,S.-J. and Shen,R.-F.
            Cloning and characterization of the human thromboxane synthase
            gene promoter.
            Biochem. Biophys. Res. Commun.  201, 379-387.
            exon 1 and promoter 

CYP5A1      human
            GenEMBL S51388 (1910bp)
            Yokoyama,C., Miyata,A., Ihara,H., Ullrich,V. and Tanabe,T.
            Molecular cloning of human platelet thromboxane A synthase.
            Biochem. Biophys. Res. Commun. 178, 1479-1484 (1991)

CYP5A1      human
            GenEMBL D34614 to D34625
            Miyata,A., Yokoyama,C., Ihara,H., Bandoh,S., Takeda,O.,
            Takahashi,E.-I. and Tanabe,T.
            Characterization of the human gene (TBXAS1) encoding thromboxane
            synthase
            Eur. J. Biochem. 224, 273-279 (1994)

CYP5A1      Pan troglodytes (chimpanzee)
            XM_003318833
            TBXAS1 
            EXTRA EXON REMOVED FROM TRANSLATION
            98% (6 AA DIFFS) TO HUMAN
MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLG                      LRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLV                      ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNE
MVPLISQACNLLLAHLKRYAE                      
SGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLL                      LSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARH                      SASPMGVQDFDIVREVFSSTGCKPNPSRQHQPSSMARPLTVDEIVGQAFIFLIAGYEI                      VTNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLKEGLPYLDMVIAETLRM                      YPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEAR                      QQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSA                      
LGPKNGVYIKIVSR

CYP5A1      Macaca fascicularis (cynomolgus monkey)
            AB220392
MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLG
LRHPKPSPFIGNLMFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLV
ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMTPLISQAC
DLLLAHLKRYAESGDAFDIQRCYRNYTTDVVASVAFGTPVDSQQAPEDPFVKHCKRFF
EFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERR
RDFLQMVLDARHSASPVGVQDFDMVGDVFSSTRCKPNPSRQHQAGPMARPLTVDEIVG
QAFIFLIAGYEIVTNTLSFATYLLATNPDCQEKLLREVDLFKEKHMVPEFCSLEEGLP
YLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE
TFNPERFTAEAQQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFQFQACPE
TQVPLQLESKSALGPKNGVYIKIVSR

CYP5A1      Bos taurus (cow)
            See cattle page for details
  94 MEVLGLFRLEVSGPMVTVALSVVFLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLAFFRQ 276
 277 GFWESHMELRKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEKFSNFTNRMAT 432
 433 GLEPKPVADSVLFLRDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERH 600
 601 AQSGEAFDIQKTYCCYTTDVVASVAFGTEVNSQEAPEHPF 720
     VEHCRRFFASSIPKPLLVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQ
     AAEERRRDFLQMVQDVRHSAATVGVENFDIVRQVFSATKCPANPPRRHSPRPLSKP
1069 LSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPECQEKLLEEVDCFSKEHLAPEYCS 1248
1249 LQEGLPYLDMVIKETLRMYPPAFRFTRVAAQDCEVLGQRIPAGAVLETAVGALHYDPE 1422
1423 HWPNPENFNPERFTAEAQQRRRPYTYLPFGAGPRSCLGVRLGLLELKLTLLHILRKFR 1596
1597 FEACPETQVPLQLESKSALGPKNGVYIRIVSR*

CYP5A1    Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          partial sequence
          82% to human 5A1, one aa diff to NM_214046.1
          Ortholog of human CYP5A1

CYP5A1    Sus scrofa (pig) 
          NM_214046.1
          82% to human 5A1
MEVLGFLSPELNGPMVTMALAVVLLALLKWYSTSAFSRLEKLGI
RHPKPSPFIGNLTFFRQGFWESHMELRKQYGPLSGYYLGRRMIVVISDPDMIKQVLAE
KFSNFTNRMATGLESKPVADSILFLRDKRWEEVRSVLTSAFSPKKLNKLTPLISQACD
LLLAHLERYAESGDAFDIQRCYCCYTTDVVASVAFGTQVNSSEEPEHPFVKHCRRFFA
FSVPRLILVLILSFPSIMVPLARILPNKKRDEVNGFFNKLIRNVIALRDQQAAEERRQ
DFLQMVLDLRHSAPSVGVENFDIVRQAFSSAKGCPADPSQPHLPRPLSKPLTVDEVVG
QAFLFLIAGYEIITNTLSFVTYLLATNPDCQEKLLREVDDFSKKHPSPEHCSLQQGLP
YLDMVLSETLRMYPPAFRFTREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHWPHPE
TFDPERFTAEAQRLQQPFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPE
TQVPLQLESKSALSPKNGVYIRIVPR

CYP5A1      Canis familaris (dog)
            XM_539887.2
MEVLSFLKLEVNGPMVTVALSVVLLALLKWYSTAAFSRLEKLGI
RHPKPSPFIGNLPFFCQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVE
NFHNFTNRMVSGLESKPVMDSVLFLRDKRWEEVRSVLTSAFSPEKLNEMTPLISQACD
LLLAHLKHYAESGDAFDIQRCYSCYTTDVVASVAFGTQVDSRRAPGDPFVKHCRRFFA
YSIPRPILVLILSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRR
DFLQLILDARHLATSLGVDSFDMVRQVFSSTDCTVGPSRPHQPRHLSQPLTLDEIVGQ
AFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLAEVDSFKEKYTALDYCSLQEGLPY
LDMVIAETLRIYPPAFRFTREAARDCEVRGQRIPAGAVVEVAVGALHRDPEYWPQPET
FNPERFKAEAQRRQQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLQVLHQFRFEACPET
QVPLQLDSKSALGPKNGIYIKIVSR

CYP5A1     chicken
           XP_416334, 63% to human CYP5A1
  1 MAAQPSAAAL TLTLSSAAEG WPMLQRGDAG RWQEDGGLVS FQGGNYIPCD KYSTSAFSKL
 61 SKVGIRHPPP LPFIGNLLFF REGFWENHTK LITEYGPVCG YYIGRQMFVV ISTPEVIKQI
121 LVTDFGNFTN RTKPNLISKP MLDSILCLRD ERWKYVRSLL TPAFSDAKLK EMIPLINQAC
181 DVLLSNLKVY ADSGRAFDIQ RCYNCFTLDV VGSVAFGTEV DSQKNPDDPF VKNCRTFFEM
241 SLFKPLLFLI LSFPFIMIPL LRILPNKKQK ELNGFFIQTI KNAIAFRDQQ DAAERRRDFL
301 QWMLDSRNSA DALAGGYFDQ ICPATTSSHN EVPLVDKTPS EKAQKMLTED EIAGQAFLFL
361 IAGYETTTST LSFATYLLAT NPECQEKLLQ EIDEFSAKHM AQDLCALEEN LPYLDMVIAE
421 TLRMFPPAFR FTREAAKDCV VLGQRIPAGA VIETAVGHLH HNPEFWPEPE KFIPERFTEE
481 AKKERHPFAY LPFGAGPRGC IGRKMGLLAT KMTLLRILQM FRFKTCPETE IPLQLKSKAT
541 LGPKNGVYII LESR

CYP5A1a     Xenopus laevis (African clawed frog)
            BC060001.1 
            92% to X. tropicalis CYP5A1
MEEPTLWGLDGCTVTFALVAGFLGLLYWYSVSAFSQLDKVGIKH
PKPLPFIGNVMLFKKGFWEGDRHLIKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDF
VNFTNRMKLNLVTKPMSDSLLCLRDDKWKRVRSVMTPSFSAIRMKEMCPLINQCCDVL
VDNLLEYASSGEACNVQRCYACYTMDVVASVAFGTQVDSQRDPDHPLVQNCKRFLELF
TPFKPLILLCLAFPSIMIPIARRLPNKQRDRINSFFLKVIRDIIAFRENQPPNERRRD
FLQLMLDAQDSVSHVTVDHFDIVNQADLSVPQNSPSEKQDRGQDPPRKSSKKLNKEEI
LGQAFIFLIAGYETTCSLLSFTSYLLATHPDCQEKLLKEVDEFSQEHKEADYNTVHDL
PYMDMVINETLRMYPPAYRFAREAARDCTVMGQNIPAGAVVEIPIGCLQNDPRFWHEP
EKFNPERFTAEEKQKRHPFLFLPFGAGPRSCIGMRLALLEAKITLYRVLQKFRFQTCD
LTQIPLQLSAMSTLRPKDGVYVTVVAR*

CYP5A1b     Xenopus laevis (African clawed frog)
            SwissProt Q6PCI4 
            93% to CYP5A1a X. laevis, 90% to CYP5A1 X. tropicalis
            ohnolog due to genome duplication in X. laevis
MEMLRLWGLDGCTVTFALVAGFLGLVYWYSVSAFSQLEKVGIKHPKPLPFIGNVMLFQK
GFWEGDRHLLKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDFVNFTNRMKFNLATKPM
SDSLLCLRDDKWKRVRSVLTPSFSAIRMKEMCPLINQCCDVLVDNLQEYASSGEACNVQ
RCYACFTMDVVASVAFGTQVDSQKDPEHPLVQNCKRFLEQFTPFKPLVLLCLAFPSIMI
PIARRLPNKQRDRINSFFLKVIRDIIAFRENQPPNERRRDFLQLMLDARDSAGHVTVDH
FDIVNQADLSVPRNSPSEKQDRGQDSPRKSTKKLNEEEILGQAFIFLIAGYETTCSLLS
FASYLLATHPECQKKLLREVDEFGREHKEADYNTVHELPYMEMVINETLRMYPPAYRFA
REAARDCTVMGLNIPAGAVVEIPIGCLQNDPRFWHEPEKFNPERFTAEEKQKRHPFLFL
PFGAGPRSCIGMRLALLEAKITLYRILKNFRFQTCDLTQIPLQLSAMSTLRPKDGVYVR
VVAR

CYP5A1      Xenopus tropicalis (Western clawed frog)
            CX843268.1 CX920105.1 CX846214.1 
            BC159143 cDNA
            scaffold_1778:46661-92162 UCSC Browser
            54% to CYP5A1 human
            missing last exon in seq gap, not in ESTdb or UCSC genome browser
            Trace archive 414884422, 418775930
MGESWLWGLDGCTVTLTLVAGFLGLLYWYSVSAFWQLEKAGIKHPKPLPFIGNI
MLFQKGFWEGDRHLLKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDFVNFTNRMRLNLV
TKPMSDSLLCLRDDKWKRVRSVLTPSFSAARMKEMCPLINQCCDVLVENLMEYASSGEAC
NVQRCYACFTMDVVASVAFGTQVDSQRDSDHPLVQNCKRFLELFTPFKPVVLLCLAFPSI
MIPIARRLPNKHRDRINSFFLKVIRDIIAFRENQPPNERRRDFLQLMLDAR
DSAGHVSVDHFDIVNQADLSVPQNQDRGQDPPRKSTQKTLNEEEILGQAFIFLIAGYETT
CSLLSFASYLLATHPDCQEKLLKEVDEFSQEHEEADYNTVHDLPYMEMVINETLRMYPPA
YRFAREAARDCTVMGLGIPAGAVVEIPIGCLQNDPRFWHEPEKFNPER (2)
FTAEEKQKRHPFLFLPFGAGPRSCIGMRLALLEAKITLYRVLRKFRFQTCDLTQ (0)
IPLQLSAMTTLRPKDGVYVRVVAR*

CYP5A1      Danio rerio (zebrafish)
            See zebrafish pages for seq

CYP5A1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_1244
            49% to 5A1 human
            N-terminal revised June 18, 2010
     MMALWEFQYIFHNTSGLSVTLGLLLLGLLYW (2)
     YSVRPFSVLSRNGIKHPKPLPFFGNLFMFRQ 7316 (0)
7158 GFFNPLNDLIKTHGRVCG 7105 (2)
7021 YYLGRKPVVVVADPEMLRQVMVKDFSSFPNRM 6926 (0)
6848 SLRFITKPMSDCLLMLRNERWKRVRSILTPAFSASKMKE 6732 (0)
6519 MVPLINTATDALIKNLDAFAESAEAFNIHK 6430 (2)
6355 CFGCFTMDVVASVAFGTQVDSQNNCDDPFVRHAQLFFSFNFFRPIMLFF 6209 (1)
6046 AAFPSLAAPLVGIIPNKKRDDMNHFFIRTIQKIIKQREEQPPEQ 5915 (0)
5794 RRRDFLQLMLDARTSDESVSIEHFDTAHPVGEAHNRSEQNQDNQVGPQERPQMKM 5630
5629 ITEDEIVGQAFVFLVAGYETSSNTLAFACYLLAINPECQRELQKEVDHFFTRH 5471 (0)
5395 ESPDYTNVQELKYLDMVISETLRLYPPGFR 5306 (2)
5229 FAREIERDCVVNGQSFPKGATFEIPAGFLHRDPEHWPDPDKFIPER (2)
4998 FTPEAKASRHPFVYIPFGAGPRNCVGMRLAQLEMKMALVRLFRRFNLLACTETK 4837 (0)
4699 VPLELKSSSTLGPKNGVFVKIERRHWDESQVNSPSED* 4586

CYP5A1     Tetraodon nigroviridis (freshwater puffer) 
MMAVWDFLNIFHNTSGLSVTLGLLLLGLIYW (2)
YSVYPFSVLSRHGIKHPKPLPFFGNLFMFHQ (0)
LTLFCLTPFSYYLGRKPVVVVADPDMLRQVMVRDFSSFPNRMV (2)
KPMSDCLLMLKNERWKRVRSILTPAFSASKMKE (0)
MVPLINTATDALMKNLDAYAESGEAFNIHK (2)
CFGCFTMDVIASVAFATQVDSQNNTDDPFVRHAQLFFSFSLFRPIALLF (1)
AAFPSIATLLVRIPNKRRDDMNHFFIGTIQKIIQQREEQPPEQ (0)
RRRDFLQLMLDARSSDASVSLEHFDTAEPAGELDTTNEQILNQDRPQRKMITEDEIVGQAFVFLVAGYETSSNTLA FACYLLAINPECQRKLQEEVDHFFTRH (0)
ELPDYTNVQELKYLDMVISETLRLYPPGFR (2)
FARNVERDCVVNGQSFPKGASLEIPAGFLHRDPEHWPDPDKFIPER (2)
FTPEAKASRHPFVYIPFGAGPRNCVGMRLAQLEMKMALVRLFRRFSLVACPETK (0)
VPLELKSSSTLGPKNGVFVKIERRQG*

6A Subfamily

CYP6A1      Musca domestica (house fly)
            GenEMBL L27241 (1982bp) L27242 (3888bp) 
            Cohen,M.B., Koener,J.F. and Feyereisen,R.
            Structure and chromosomal localization of CYP6A1, a cytochrome
            P450-encoding gene from the house fly.
            Gene 146, 267-272 (1994)

Cyp6a2      Drosophila  melanogaster (fruit fly)
            GenEMBL S51248 (1689bp) M88009 (2848bp) 
            GenEMBL S36482 S36608 (cross-reference numbers from SwissProt
            but they do not match any sequences in Genbank)
            Swiss P33270 (507 amino acids) PIR A45378 A47198 (507 amino acids)
            Waters,L.C., Zelhof,A.C., Shaw,B.J. and Ch'ang,L.-Y.
            Possible involvement of the LTR of transposable element
            17.6 in regulating expression of an insecticide resistance
            associated P450 gene in Drosophila.
            Proc. Natl. Acad. Sci. USA 89, 4855-4859 (1992)
            correction: PNAS 89, 12209, (1992)
            Note: This is P450-B1, the sister sequence P450-A1 is CYP4G1.

Cyp6a2      Drosophila melanogaster (fruit fly)
            GenEMBL U78088(5737bp)
            Dunkov, B.C., Guzov, V.M., Mocelin, F., Shotkoski, F., Brun, A., 
            Amichot, R., ffrench-Constant, R.H. and Feyereisen,R.
            The Drosophila melanogaster gene Cyp6a2: Structure, localization, 
            heterologous expression and induction by phenobarbital.
            submitted (1996)

Cyp6a2      Drosophila melanogaster (fruit fly)
            GenEMBL AC007549 comp(100072-101661)

Cyp6a2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP6A3      Musca domestica (housefly)
            GenEMBL U09231 (2142bp)
            Cohen,M.B. and Feyereisen,R.
            A cluster of P450 genes of the CYP6 family in the house fly.
            DNA and Cell Biol. 14, 73-82 (1995)

CYP6A4      Musca domestica (housefly)
            GenEMBL U09232 (2089bp)
            Cohen,M.B. and Feyereisen,R.
            A cluster of P450 genes of the CYP6 family in the house fly.
            DNA and Cell Biol. 14, 73-82 (1995)

CYP6A5v1    Musca domestica (housefly)
            GenEMBL U09343 (2110bp)
            Cohen,M.B. and Feyereisen,R.
            A cluster of P450 genes of the CYP6 family in the house fly.
            DNA and Cell Biol. 14, 73-82 (1995)

CYP6A5v2    Musca domestica (house fly)
            No accession number 
            Nannan Liu
            submitted to nomenclature committee 7/20/06
            clone #10-3
            7 aa diffs to 6A5v1

CYP6A6      Musca domestica (housefly)
            GenEMBL U09344 (718bp)
            Cohen,M.B. and Feyereisen,R.
            A cluster of P450 genes of the CYP6 family in the house fly.
            DNA and Cell Biol. 14, 73-82 (1995)

CYP6A7      Musca domestica (housefly)
            Rene Feyereisen
            Submitted to nomenclature committee

Cyp6a8      Drosophila melanogaster
            GenEMBL L46859(1595bp) AC020447 comp(122688-124264)
            Maitra,S., Dombrowski,S.M., Waters,L.C. and Ganguly,R.
            Organization and expression of new cytochrome P450 (Cyp) genes of
            Drosophila melanogaster.
            Unpublished (1995)

Cyp6a8      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a9      Drosophila melanogaster
            GenEMBL L46860(1591bp) AC020447 comp(115043-116610)
            Maitra,S., Dombrowski,S.M., Waters,L.C. and Ganguly,R.
            Organization and expression of new cytochrome P450 (Cyp) genes of
            Drosophila melanogaster.
            Unpublished (1995)

CYP6A10     Ceratitis capitata (Mediterranean fruit fly)
            GenEMBL U78795(1720bp)
            Danielson,P.B., Foster,J.L.M., Cole,S.K. and Fogleman,J.C.
            unpublished (1996)

CYP6A11     Ceratitis capitata (Mediterranean fruit fly)
            Phil Danielson
            Submitted to nomenclature committee
            MD154 PCR of C-terminal

CYP6A12     Ceratitis capitata (Mediterranean fruit fly)
            Phil Danielson
            Submitted to nomenclature committee
            MD47 PCR of C-terminal

Cyp6a13     Drosophila melanogaster
            GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, region 44D1-
            44D2, DS08616, complete sequence [Drosophila melanogaster]
            4-474 comp(7564-8986) 52% identical to CYP6A5

Cyp6a13     Drosophila melanogaster
            GenEMBL AC020451 3757-5238 also AC007085 126189-124714 no introns
MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIY
RKFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFL
DGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFTTDVI
GSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVS
EFFLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTS
STTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPI
LPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKAR
HPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQ
EGVHLRMEGLERP

Cyp6a13     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a14     Drosophila melanogaster
            GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, 
            region 44D1-44D2, 2-474 13565-15095 57% identical to CYP6A5

Cyp6a14     Drosophila melanogaster
            GenEMBL AC007085 33266-34850
MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIY
KKFKGQGPIAGMYTFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFAL
EGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCA
RFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIK
VLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTL
EQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVL
AQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIY
PEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVS
NRTDVPLIFSKKSFLLTTNDGIYLKVERV

Cyp6a14     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a15p    Drosophila melanogaster
            GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, region 
            44D1-44D2, mid to heme comp(10139-9361) POSSIBLE PSEUDOGENE 
            (MISSING N-TERMINAL)

Cyp6a15p    Drosophila melanogaster
            GenEMBL AC020451 2595-3373 with in frame stops and frame shifts
AFTVTNSKLAKKLKMKILRDDLTDFFLSVVKPALSGMTLWTSPPSGGRSSRQGGSKFDLS
HNWTLEQMAAQAIVFFLAGFETSSSTMSSCKYELALQPEI*NQIRDEIERVLEGNAITYD
ALAKINYPEQVLSETLRKHPIQLIKFLLETQESFRVRNTELIVEKGTSLLIPVHSVHYDP
HLYPHPKLFDSSRLKAYKSNSRHPFAYLPFGTFGPRSCIGLRFGKMQAKIGIVSLCQRFK
FGDSDLTDIPL

Cyp6a16p    Drosophila melanogaster
            GenEMBL AC004721 comp(2956-5070) 
            47% to 6a8
            1 exta A nucleotide after MDLLLDLRR causes a frameshift

Cyp6a16     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a17     Drosophila melanogaster
            GenEMBL AC020447 109264-110826 complete
            AL052842 assembled from fragments only 
            AL074108 AA699131 AI135898 AI260230 AI258456
            AI534145 AI114010 AI533952 AI402220
            49% with 6a2

Cyp6a17     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a18     Drosophila melanogaster
            GenEMBL AC008285 85740-87319 AI403838

Cyp6a19     Drosophila melanogaster
            GenEMBL AC020447 113084-114646

Cyp6a20     Drosophila melanogaster
            GenEMBL AC020447 117416-119045

Cyp6a20     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a21     Drosophila melanogaster
            GenEMBL AC020447 comp(120585-122149)

Cyp6a21     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a22     Drosophila melanogaster
            GenEMBL L46858 AC020447 106987-108653
            Ranjan Ganguly

Cyp6a22     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6a23     Drosophila melanogaster
            GenEMBL AC020447 111145-112718

Cyp6a23     Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP6A24     Musca domestica (housefly)
            No accession number
            Eriko Kamiya
            Submitted to nomenclature committee 1/8/2000
            62% to CYP6A1

CYP6A25    Musca domestica (housefly)
           No accession number
           Rene Feyereisen
           Submitted to nomenclature committee Feb. 20, 2000
           Clone name TA14-1

Cyp6a26   Drosophila simulans
          No accession number
          Sophie Tares-Amichot
          Submitted to nomenclature committee Sept. 29, 2000
          96% to Cyp6a2, probable ortholog to 6a2

CYP6A27   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          revised June 27, 2005 to full length 
          Clone name Lc_CYP6A8 
          61% to 6A9 64% to 6A32

CYP6A28   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          revised June 27, 2005 to full length 
          Clone name Lc_CYP6A2 
          52% to 6A9 63% to 6A1 and 6A24

CYP6A29   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A7 
          50% to 6A9 63% to 6A28 (307 aa)

CYP6A30   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A1 
          59% to 6A16 (308 aa)

CYP6A31   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A3 
          60% to 6A14 (355 aa)

CYP6A32   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A4 
          58% to 6A9 64% to 6A27 (347 aa)

CYP6A33   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A5 
          51% to 6A16 78% to 6A34 60% to 6A30 (309 aa)

CYP6A34   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A6 
          49% to 6A16 78% to 6A33 (309 aa)

CYP6A35   Lucilia cuprina (Australian blowfly)
          No accession number 
          Zhenzhong Chen
          Submitted to nomenclature committee March 17, 2005
          Clone name Lc_CYP6A9 
          60% to 6A9 (262 aa)

CYP6A36   Musca domestica (house fly)
          No accession number
          Nannan Liu
          59% identical to 6a21, 61% to 6A27, 58% to 6A37
          clone #15
          submitted to nomenclature committee 4/10/06

CYP6A37   Musca domestica (house fly)
          No accession number
          Nannan Liu
          66% to 6A9, 67% to 6A7 first 334 aa
          clone #15prime
          submitted to nomenclature committee 4/10/06

CYP6A38v1 Musca domestica (house fly)
          No accession number
          Nannan Liu
          submitted to nomenclature committee 7/20/06
          clone #17
          ONLY 4 AA DIFFS PLUS 2 FRAMESHIFTS  TO 6A38v2
          98% to AB050019.1  Musca domestica CYP6A24 (7 aa  diffs)
          12 aa diffs to 6A39
          could be an allele of 6A24, or in a gene cluster with 6A genes

CYP6A38v2 Musca domestica (house fly)
          No accession number
          Nannan Liu
          submitted to nomenclature committee 7/20/06
          clone #16-2
          ONLY 4 AA DIFFS PLUS 2 FRAMESHIFTS  TO 6A38v1
          96% (16 aa diffs to 6A39)
          could be an allele of 6A24, or in a gene cluster with 6A genes

CYP6A39   Musca domestica (house fly)
          No accession number
          Nannan Liu
          submitted to nomenclature committee 7/20/06
          clone #16-8
          49% to 6A2, 12 aa diffs to 6A38v1
          16 diffs plus two frameshifts to 6A38v2
          97% to AB050019.1  13 aa diffs TO 6A24
          could be an allele of 6A24, or in a gene cluster with 6A genes

CYP6A40   Musca domestica (housefly) insecticide-susceptible strain TJS
          No accession number
          Qi Gao
          Submitted to nomenclature committee April 2, 2009
          top 19 BLAST hits are all CYP6A sequences
          52% to Cyp6a9 D. melanogaster
          47% to CYP6A1 Musca domestica
          47% to Cyp6a2 D. melanogaster
          43% to CYP6A3 Musca domestica
          44% to CYP6A4 Musca domestica
          44% to CYP6A5 Musca domestica
          46% to CYP6A6 Musca domestica (partial seq)
          49% to CYP6A7 Musca domestica (partial seq)
          45% to CYP6A24 Musca domestica
          50% to CYP6A25 Musca domestica (partial seq)
          49% to CYP6A36 Musca domestica
          51% to CYP6A37 Musca domestica
          45% to CYP6A38v1 Musca domestica
          45% to CYP6A39 Musca domestica
          sequence # 1 

CYP6A41     Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            65% to CYP4A10 Ceratitis capitata (Mediterranean fruit fly)

CYP6A41     Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Hu-liming 
            submitted to nomenclature committee 9/26/2011
            99% to CYP6A41 from Jiang Hongbo, 4 amino acid differences

CYP6A42     Lucilia sericata
CYP6A43     Lucilia sericata
CYP6A44     Lucilia sericata
CYP6A45     Lucilia sericata
CYP6A46     Lucilia sericata
CYP6A47     Lucilia sericata

CYP6A48     Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            54% to Cyp6a23 D. melanogaster
            clone name 926

CYP6A49     Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            55% to CYP6A50 Bactrocera dorsalis, 50% to CYP6A28 Lucilia cuprina
            top 21 hits are all CYP6A
            clone name 1204

CYP6A50     Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            53% to Cyp6a9 D. melanogaster, 55% to CYP6A49 Bactrocera dorsalis
            top 28 hits are all CYP6A
            clone name 1400

CYP6A51     Ceratitis capitata (Mediterranean fruit fly)
            No accession number
            Rene Feyereisen and Pedro Hernandez
            submitted to nomenclature committee Oct. 8, 2012
            58% to CYP6A48 Bactrocera dorsalis

6B Subfamily

CYP6B1      Papilio polyxenes (black swallowtail butterfly)
            GenEMBL S48952 M80828 (1623bp) M83117 (1608bp)
            Swiss Q04552 Q04553 (498 amino acids) PIR A46367 (498 amino acids)
            Cohen,M.B., Schuler,M.A. and Berenbaum,M.R.
            A host-inducible cytochrome P450 from a host specific
            caterpillar: molecular cloning and evolution.
            Proc. Natl. Acad. Sci. USA 89, 10920-10924 (1992)
            Note: have not been able to download S48952 from GCG or NCBI.

CYP6B1      Papilio polyxenes (black swallowtail butterfly)
            GenEMBL Z29624 (3191bp)
            Prapaipong,H.H., Berenbaum,M.M. and Schuler,M.M.
            Transcriptional regulation of the Papilio polyxenes CYP6B1 gene.
            Nuc. Acids Res. 22, 3210-3217 (1994)

CYP6B1v3    Papilio polyxenes (black swallowtail butterfly)
            GenEMBL U05037 (3191BP)
            Prapaipong,H. Berenbaum,M.R., Schuler,M.A.
            Transcriptional regulation of the Papilio polyxenes CYP6B1 gene.
            unpublished (1994)

CYP6B1v1/v2Papilio polyxenes (black swallowtail butterfly)
            no accession number 
            Ma, R., Cohen,M.B., Berenbaum,M.R. and Schuler,M.A.
            Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that 
            selectively metabolize linear furanocoumarins.
            Arch. Biochem. Biophys. 310, 332-340 (1994)

CYP6B2/CYP6B6 chimera  Helicoverpa armigera (Australian cotton bollworm) 
            GenEMBL U18085 (1995bp)
            Wang,X. and Hobbs,A.A.
            Isolation and Sequence Analysis of a cDNA clone for a Pyrethroid
            Inducible Cytochrome P450 from Helicoverpa armigera.
            Unpublished (1995)
            Note: this sequence is reported to be a chimera of 6B2 and 6B6
            The first 90 aa do not seem to belong to 6B2
            Pers. Comm. David G. Heckel
            The N-term seq of U18085 is very similar to 6B6, 6B9 and 6B27
            With 3-4 amino acid differences.

CYP6B2v1    Helicoverpa armigera (cotton bollworm)
            No accession number
            David G. Heckel 
            submitted to nomenclature committee Feb. 21, 2005
            HaCypZ017a-v1Pep
            59% to 6B29 96% to 6B2 18 aa diffs in first 90aa 
            only 2 aa diffs after that. (alternative splicing?)

CYP6B2v2    Helicoverpa armigera (cotton bollworm)
            No accession number
            David G. Heckel 
            submitted to nomenclature committee Feb. 21, 2005
            HaCypZ017b-v2Pep
            58% to 6B29 2aa diffs to CYP6B2v2

CYP6B2v3    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH000107 4 aa diffs to Ha-12E11-C (R. Feyereisen) 
            in a CYP6B gene cluster
            11 aa diffs to CYP6B2v1
            The related sequence HAH013651 has 4 aa diffs to HAH000107
            The genes in this cluster are complicated by
            Polymorphism and sequencing of different haplotypes
            and different strains.  There is potential for name changes.

CYP6B6v1    Helicoverpa armigera (Australian cotton bollworm)
            U64800
            Note: this gene cluster has at least 5 genes
            CYP6B7, 6B6, 6B2 and two more
            There is high polymorphism and the 
            haplotypes are being examined in more detail

CYP6B6v2    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_187 99% to 6B6v1 U64800, 4 aa diffs
            in a CYP6B gene cluster
            The related sequence Contig_271 has 3 aa diffs to Contig_187
            The genes in this cluster are complicated by
            Polymorphism and sequencing of different haplotypes
            and different strains.  There is potential for name changes.

CYP6B3      Papilio polyxenes (black swallowtail butterfly)
            GenEMBL U25819 (1599bp)
            Hung,C.-F., Harrison,T.L., Berenbaum,M.R. and Schuler,M.A.
            CYP6B3-A Second Furanocoumarin-inducible Cytochrome P450 Expressed
            in Papilio polyxenes
            Insect Biochem. and Mol. Biol. (1995) In press

CYP6B3v2    Papilio polyxenes (black swallowtail butterfly)
            GenEMBL U65488(2978bp)
            Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
            Conserved promoter elements in the CYP6B gene family suggest common
            ancestry for cytochrome P450 monooxygenases mediating
            furanocoumarin detoxification
            unpublished (1996)

CYP6B4      Papilio glaucus (butterfly)
            GenEMBL U47059(1619bp)
            Hung,C.F., Berenbaum,M.R. and Schuler,M.A.
            Isolation and characterization of a furanocoumarin-inducible
            cytochrome P450 cDNA from a polyphagous lepidopteran.
            unpublished (1996)
            cDNA slight difference with both genomic sequences

CYP6B4v1    Papilio glaucus (butterfly)
            GenEMBL U65490(2957bp)
            Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
            Conserved promoter elements in the CYP6B gene family suggest common
            ancestry for cytochrome P450 monooxygenases mediating
            furanocoumarin detoxification.
            unpublished (1996)

CYP6B4v2    Papilio glaucus (butterfly)
            GenEMBL U65489(4279bp)
            Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
            Conserved promoter elements in the CYP6B gene family suggest common
            ancestry for cytochrome P450 monooxygenases mediating
            furanocoumarin detoxification.
            unpublished (1996)

CYP6B5      Papilio glaucus (butterfly)
            Hung,C.-F. and Schuler,M.
            no accession number
            genomic DNA missing last 24 amino acids
            1 aa difference from B4v2, both B4v2 and B5 on one piece of DNA 
            submitted to Nomenclature Committee

CYP6B6      Helicoverpa armigera (Australian cotton bollworm) 
            GenEMBL U64800(1936bp)
            Ranasinghe,C. and Hobbs,A.A.
            A member of the cytochrome P450 family CYP6B from Helicoverpa
            armigera.
            unpublished (1996)

CYP6B6      Helicoverpa armigera (Australian cotton bollworm)
            Note: this gene cluster has at least 5 genes
            CYP6B7, 6B6, 6B2 and two more
            There is high polymorphism and the 
            haplotypes are being examined in more detail

CYP6B7      Helicoverpa armigera (Australian cotton bollworm) 
            GenEMBL AF031468 (2411bp)
            Ranasinghe,C. and Hobbs,A.A.
            Complete cDNA sequence for Cytochrome P450 CYP6B7 from Helicoverpa
            armigera (Cotton Bollworm)
            Unpublished

CYP6B7      Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            1 aa diff.

CYP6B8v1    Helicoverpa zea
            GemEMBL AF102263
            Li,X.C., Berenbaum,M.R. and Schuler,M.A.
            Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible
            cytochrome P450 cDNA from Helicoverpa zea
            Insect Biochem. Mol. Biol. 30, 75-84 2000
            submitted to nomenclature committee 10/27/98
            99% identical to 6B7 (this is the orthologous gene to 6B7)

CYP6B8v2    Helicoverpa Zea
            GenEMBL AF285828
            Xianchun Li
            Clone name: P6
            very similar to 6B8
            Submitted to nomenclature committee June 14, 2000

CYP6B8v3    Helicoverpa Zea
            GenEMBL AF285829
            Xianchun Li
            Clone name: P12
            very similar to 6B8
            Submitted to nomenclature committee June 14, 2000

CYP6B8v4    Helicoverpa Zea
            GenEMBL AF285830
            Xianchun Li
            Clone name: P15
            very similar to 6B8
            Submitted to nomenclature committee June 14, 2000

CYP6B8v5   Helicoverpa Zea
           GenEMBL AF285186
           Xianchun Li
           Clone name: P23
           Intron sequence differs from 6B8 by 229 bp insertion otherwise very 
           similar to 6B8
           Submitted to nomenclature committee June 14, 2000
           formerly CYP6B28 but now an allele of CYP6B8

CYP6B8v6    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_208 99% to 6B8v1 (2 aa diffs)
            in a CYP6B gene cluster
            The genes in this cluster are complicated by
            Polymorphism and sequencing of different haplotypes
            and different strains.  There is potential for name changes.

CYP6B9      Helicoverpa zea
            no accession number
            Satish Pimprale
            submitted to nomenclature committee 10/6/98
            most like CYP6B6 (95% identity) 90% with 6B2, 86% with 6B7 
            and 87% with 6B8

CYP6B10v1   Heliothis virescens (tobacco budworm)
            no accession number
            Satish Pimprale
            submitted to nomenclature committee 10/6/98
            most like CYP6B6 (92% identity) 86% with 6B2, 6B7 and 6B8

CYP6B10v2   Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            96% to CYP6B10v1 Heliothis virescens

CYP6B11     Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-F2
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B12    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            SF-F47
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B13    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-C1
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B14    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-P46
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B15    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-P47
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B16    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            SF-F28
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B17    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            IN-G1
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B18    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-F54
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B19    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-F17
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B20    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            SF-F61
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B21    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            SF-F46
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B22    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-F8
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B23    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            SF-X9
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B24    Papilio glaucus
            No accession number
            Weimin Li and May Berenbaum
            SF-X43
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B25    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-X21
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B26    Papilio canadensis
            No accession number
            Weimin Li and May Berenbaum
            CAN-X22
            Note: all 6b11-6b26 sequences are very similar at the protein level
            They have been given different gene names because they have insertions/
            deletions in their intron and 5 prime flanking regions that suggest they are different genes

CYP6B27    Helicoverpa Zea
           GenEMBL AF285831
           Xianchun Li
           Clone name: 6B6G13R4
           Intron sequence differs from 6B9
           Submitted to nomenclature committee June 14, 2000

CYP6B28X   Helicoverpa Zea
           GenEMBL AF285186
           Xianchun Li
           Clone name: P23
           Intron sequence differs from 6B8 by 229 bp insertion otherwise very 
           similar to 6B8
           Submitted to nomenclature committee June 14, 2000
           Renamed CYP6B8v5 an allele of CYP6B8

CYP6B29     Bombyx mori (silkworm)
            BAAB01105883.1 BAAB01064450.1
            51% TO 6B1
            See silkworm page for sequence

CYP6B29     Bombyx mori (silkworm)
            GenEMBL DQ252324
            Wang,D., Xu,Y.X., Wei,Z.G., Zhao,H.Q., Chen,Y.H., 
            Li,B., Gong,C.L. and Shen,W.D.
            Only 8 differences to 6B29 Bombyx mori genomic seqs
            Since one of the genomic diffs is a stop codon
            This mRNA seq is probably the more accurate seq

CYP6B29     Bombyx mandarina (wild silkworm)
            GenEMBL DQ252325
            Wang,D., Xu,Y.X., Wei,Z.G., Zhao,H.Q., Chen,Y.H., 
            Li,B., Gong,C.L. and Shen,W.D.
            Only 4 differences to 6B29 Bombyx mori genomic seqs

CYP6B30     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            Submitted to nomenclature committee Jan. 13, 2004
            94% to CYP6B25

CYP6B31     Spodoptera exigua (beet armyworm)
            No accession
            Katsuya Natsuhara
            Submitted to nomenclature committee Jan. 27, 2005
            74% to 6B2

CYP6B32     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            2 aa diffs to PMC5-8, 3 aa diffs to PMC7-13,  
            3 aa diffs to PMC5-15, 6 aa diffs to PMC6-15, 7 aa diffs to PMC6-13
            91% to 6B30
            clone name PMC5-4
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva.  Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.

CYP6B33     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            1 aa diff to PMC5-15 , 2 aa diffs to PMC5-4, 91% to 6B30
            clone name PMC5-8
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva.  Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.

CYP6B34     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            1 aa  diff to PMC5-8, 91% to 6B30
            clone name PMC5-15
note: 6B32-6B37 came from a single larvae, so there cannot be six alleles of a
single gene in one larvae.  Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.

CYP6B35     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            6 aa diffs to PMC7-13, 90% to CYP6B30
            clone name PMC6-13
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva.  Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.

CYP6B36     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            6 aa diffs to PMC5-4, 91% to CYP6B30
            clone name PMC6-15
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva.  Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.

CYP6B37     Papilio multicaudatus
            No accession number
            Wenfu Mao and May Berenbaum
            3 aa diffs to PMC5-4, 91% to CYP6B30
            clone name PMC7-13
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva.  Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.

CYP6B38     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            95% to 6B39, 79% to 6B40, 75% to 6B42,
            74% to CYP6B6 Helicoverpa armigera, 73% to CYP6B2v1, 73% to 6B27

CYP6B39     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            95% to 6B38, 79% to 6B40, 76% to 6B42,
            74% to CYP6B6 Helicoverpa armigera

CYP6B40     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            79% to 6B38, 79% to 6B39,
            74% to CYP6B6 Helicoverpa armigera, 73% to 6B2 Helicoverpa armigera

CYP6B41     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            73% to 6B39, 71% to 6B6

CYP6B42     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            76% to 6B6, 77% to 6B7

CYP6B42     Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            93% to CYP6B42 Spodoptera frugiperda (probable ortholog)

CYP6B43.a   Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_157 54% to CYP6B2 N-term aa 1-164, might join with Contig_259
            HAH005783 is 100% to Contig_157
            in a CYP6B gene cluster
            The genes in this cluster are complicated by
            Polymorphism and sequencing of different haplotypes
            and different strains.  There is potential for name changes.

CYP6B43.b   Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_259 37% to 6B27 aa 174-340 mid region, 
            HAH005621 is 100% to Contig_259
            might join with Contig_157
            in a CYP6B gene cluster
            The genes in this cluster are complicated by
            Polymorphism and sequencing of different haplotypes
            and different strains.  There is potential for name changes.

CYP6B43     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            90% to CYP6B43.a Helicoverpa armigera
            85% to CYP6B43.b Helicoverpa armigera

CYP6B44     Amyelois transitella (Navel orangeworm)
            No accession number 
            Guodong Niu
            submitted to nomenclature committee May 27, 2008
            clone AL55-2
            55% to CYP6B29

CYP6B45    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6B46    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6B47    Spodoptera litura (common cutworm)
           No accession number
           Jialiang Zhou
           submitted to nomenclature committee July 28, 2009
           84% to CYP6B39

CYP6B48    Spodoptera litura (common cutworm)
           No accession number
           Jialiang Zhou
           submitted to nomenclature committee July 28, 2009
           85% to CYP6B39, 94% to CYP6B47

CYP6B48     Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            95% to CYP6B48 Spodoptera litura (probable ortholog)
            93% to CYP6B47 Spodoptera litura 

CYP6B49     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            94% to CYP6B27 Helicoverpa zea

CYP6B49     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            93% to CYP6B6v2 Helicoverpa armigera

CYP6B50     Spodoptera frugiperda (a moth)
            No accession number
            Rene Feyereisen
            Submitted to nomenclature committee Aug. 1, 2011
            64% to CYP6B43 Heliothis virescens

CYP6B51    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6B52    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6B53    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

6C Subfamily

CYP6C1      Musca domestica (housefly)
            GenEMBL U09233 (2310bp)
            Cohen,M.B. and Feyereisen,R.
            A cluster of P450 genes of the CYP6 family in the house fly.
            DNA and Cell Biol. 14, 73-82 (1995)

CYP6C2      Musca domestica (housefly)
            GenEMBL U09345 (1801bp)
            Cohen,M.B. and Feyereisen,R.
            A cluster of P450 genes of the CYP6 family in the house fly.
            DNA and Cell Biol. 14, 73-82 (1995)

6D Subfamily

CYP6D1      Musca domestica (housefly)
            GenEMBL U15168 (1551bp)
            Tomita,T. and Scott,J.G.
            cDNA and deduced protein sequence of CYP6D1: the putative gene for
            a cytochrome P450 responsible for pyrethroid resistance in the
            house fly.
            Insect Biochem. Molec. Biol. 25, 275-283 (1995)
            Liu,N., Tomita,T. and Scott,J.G.
            Allele-specific PCR reveals the CYP6D1 is on chromosome 1 in the
            house fly, Musca domestica.
            Unpublished (1995)

CYP6D1      Musca domestica (housefly)
            GenEMBL U22362(1551bp)
            Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
            Molecular mechanisms involved in increased expression of a
            cytochrome P450 responsible for pyrethroid resistance in the
            housefly, Musca domestica
            Insect Mol. Biol. 4 (3), 135-140 (1995)

CYP6D1      Musca domestica (housefly)
            GenEMBL U22366(1548bp)
            Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
            Molecular mechanisms involved in increased expression of a
            cytochrome P450 responsible for pyrethroid resistance in the
            housefly, Musca domestica
            Insect Mol. Biol. 4 (3), 135-140 (1995)

CYP6D1      Musca domestica (housefly)
            GenEMBL U22367(1551bp)
            Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
            Molecular mechanisms involved in increased expression of a
            cytochrome P450 responsible for pyrethroid resistance in the
            housefly, Musca domestica
            Insect Mol. Biol. 4 (3), 135-140 (1995)

CYP6D1      Musca domestica strain LPR (house fly)
            GenEMBL AF064794
            Scott,J.G., Liu,N., Wen,Z., Smith,F.F. and Horak,C.E.
            House fly cytochrome P450 CYP6D1: 5' flanking sequences and
            comparison of two alleles
            Unpublished
            CYP6D1v1 allele, complete cds.

CYP6D1v2    Musca domestica (housefly)
            Scott,J.
            submitted to Nomenclature Committee

CYP6D1v3    Musca domestica strain LPR (house fly)
            GenEMBL AF064795
            Scott,J.G., Liu,N., Wen,Z., Smith,F.F. and Horak,C.E.
            House fly cytochrome P450 CYP6D1: 5' flanking sequences and
            comparison of two alleles
            Unpublished
            CYP6D1v3 allele, complete cds.

CYP6D1v4    Musca domestica (housefly)
            Scott,J.
            submitted to Nomenclature Committee

CYP6D1v5    Musca domestica (housefly)
            Scott,J.
            submitted to Nomenclature Committee

Cyp6d2      Drosophila melanogaster
            Berkeley Drosophila Genome Project P1 clone DS00837 subclone 2a10 (-) 
            strand
            complete genomic sequence, 4 exons

Cyp6d2variant        Drosophila melanogaster
            Andrew Hobbs
            exon 4    48/53 amino acids identical
            submitted to Nomenclature Committee

Cyp6d2      Drosophila melanogaster
            GenEMBL AC020206 comp(66328-68065) also AC008350

Cyp6d2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP6D3v1      Musca domestica (housefly)
            Scott,J.
            submitted to Nomenclature Committee 10/28/99
            79% identical to 6D1

CYP6D3v2  Musca domestica (housefly)
           Eriko Kamiya
           Submitted to nomenclature committee Sept. 17, 2000
           98% identical to CYP6D3v1

Cyp6d4      Drosophila melanogaster
            GenEMBL AC017250 37993-39657 also AC008197 AC009846

Cyp6d4      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6d5      Drosophila melanogaster
            GenEMBL AC018176 comp(132649-134791)

Cyp6d5      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP6D6      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP6D1 
            62% to 6D2 70% to 6D3 (366 aa)

CYP6D7      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Sequence revised on Dec. 18, 2007
            Original Clone name Lc_CYP6D2 
            New clone name Luce0098H18 (full length)
            61% identical to Drosoph. CYP6d5

CYP6D8      Musca domestica (housefly) insecticide-susceptible strain TJS
            No accession number
            Qi Gao
            Submitted to nomenclature committee April 2, 2009
            56% to Cyp6d5 D. melanogaster
            sequence # 3 

CYP6D9      Bactrocera orientalis (oriental fruit fly)
            No accession number
            Yong Huang
            Submitted to nomenclature committee March 16, 2012
            60% to CYP6D7 Lucilia cuprina

6E Subfamily

CYP6E1      Culex quinquefasciatus Say (mosquito)
            GenEMBL AB001323
            Shinji Kasai
            Culex-1

CYP6E1     Culex pipiens

6F Subfamily

CYP6F1      Culex quinquefasciatus Say (mosquito)
            Shinji Kasai
            Culex-2
            submitted to Nomenclature Committee

CYP6F1      Culex pipiens

CYP6F2      Aedes aegypti (yellow fever mosquito)

CYP6F3      Aedes aegypti (yellow fever mosquito)

CYP6F4      Culex pipiens

CYP6F5P     Culex pipiens

CYP6F6      Culex pipiens

Cyp6g1      Drosophila melanogaster
            no accession number
            Phil Danielson
            Submitted to nomenclature committee 6/13/98
            CS39

Cyp6g1      Drosophila melanogaster
            GenEMBL AC015208 comp(21239-22935) also AC007440

Cyp6g1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6g2      Drosophila melanogaster
            GenEMBL AC015208 19014-20624

Cyp6g2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP6G3      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            revised to full length June 27, 2005
            Clone name Lc_CYP6G 
            60% to 6G1

CYP6G4      Musca domestica (housefly) insecticide-susceptible strain TJS
            No accession number
            Qi Gao
            Submitted to nomenclature committee April 2, 2009
            60% to Cyp6g1 D. melanogaster
            sequence # 2 

CYP6G5a     Lucilia sericata (sheep Blowfly)
CYP6G5b     Lucilia sericata (sheep Blowfly)

CYP6G6      Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            50% to Cyp6g2 D. pseudoobscura, 48% to CYP6G4 Musca domestica
            43% to CYP6AQ17 Pogonomyrmex barabatus
            clone name 736

CYP6H1      Locusta migratoria migratorioides
            GenEMBL AF115777
            Jochen Winter, Graeme Bilbe, Hanny Richener, Bernd Sehringer, Hartmut 
            Kayser
            Cloning of a cDNA Encoding a Novel Cytochrome P450 from the Insect 
            Locusta migratoria: CYP6H1, a Putative Ecdysone 20-Hydroxylase
            BBRC 259, 305-310 (1999)
            Submitted to nomenclature committee 12/2/98

CYP6J1      Blattella germanica (German cockroach)
            no accession number
            Jeff Scott
            submitted to nomenclature committee 1/20/99
            41% identical to 6H1

CYP6J2      Blattella germanica (German cockroach)
            No accession number
            Ameya D. Gondhalekar and Mike Scharf
            submitted to nomenclature committee Nov. 21, 2010
            49% to CYP6J1 in the N-terminal only

CYP6K1      Blatella germanica (German cockroach)
            no accession number
            Jeff Scott
            submitted to nomenclature committee 3/9/99

CYP6L1      Blatella germanica (German cockroach)
            GenEMBL AF227531
            Wen, Z. and Scott, J.G.
            Cytochrome P450 CYP6L1 is specifically expressed in the
            reproductive tissues of adult male German cockroaches, Blattella
            germanica (L.)
            Insect Biochem. Molec. Biol. 31: 179-187 (2001)
            submitted to nomenclature committee 2/11/99
            41% to CYP6H1, 35% to 6J1

CYP6M1      Anopheles gambiae
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 04I gene D 
            CYPm3r7 on chromosome 3
            47% identical to CYP6A5

CYP6M1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r7

CYP6M1      Anopheles funestus
            No accession number 
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            Submitted to nomenclature committee 1/5/05
            81% to 6M1v2 probable ortholog, 66% to 6M2

CYP6M1a    Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           Tandem duplication with CYP6M1b and CYP6M1c (88-90% identical)
           82% to CYP6M1 An. gambiae

CYP6M1b    Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           Tandem duplication with CYP6M1a and CYP6M1c (88-90% identical)
           79% to CYP6M1 An. gambiae

CYP6M1c    Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           Tandem duplication with CYP6M1a and CYP6M1b (88-90% identical)
           83% to CYP6M1 An. gambiae

CYP6M2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r9

CYP6M3      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r10

CYP6M4      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r11

CYP6M4     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           79% to CYP6M4 An. gambiae

CYP6M5      Aedes aegypti (yellow fever mosquito)

CYP6M5v1    Aedes aegypti (mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I1.4

CYP6M5v2    Aedes aegypti (mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I1.1

CYP6M6      Aedes aegypti (yellow fever mosquito)

CYP6M6      Aedes aegypti (mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T1-1

CYP6M7     Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 6/14/04
           CYP6 Contig 3, aa 316-440
           89% to 6M3, 76% to 6M2
           probable ortholog of 6M3

CYP6M8     Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 6/14/04
           CYP6 Contig 4, aa 317-441
           91% to 6M2, 80% to 6M3
           probable ortholog of 6M2

CYP6M9      Aedes aegypti (yellow fever mosquito)

CYP6M10     Aedes aegypti (yellow fever mosquito)

CYP6M11     Aedes aegypti (yellow fever mosquito)

CYP6M12    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/19/07
           sequence 6
           83% to CYP6M6 Aedes

CYP6M12    Culex pipiens

CYP6M13    Culex pipiens

CYP6M14    Culex pipiens

CYP6M15    Culex pipiens

CYP6M16    Culex pipiens

CYP6N1      Anopheles gambiae
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 12D2
            46% identical to CYP6E1

CYP6N1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r8

CYP6N1     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           82% to CYP6N1 An. gambiae

CYP6N2      Anopheles gambiae (formerly CYP6Q1)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 04I gene A
            46% identical to CYP6A1 and 6E1 52% to 6N1
            renamed CYP6N2 based on close sequence similarity to 6N3 and 6N4 sequences

CYP6N2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r4

CYP6N2      Anopheles funestus (mosquito)
            no accession number
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            submitted to nomenclature committee 11/17/04
            submitted name sequence 4
            89% identical to CYP6N2 Anopheles gambiae probable ortholog

CYP6N2     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           92% to CYP6N2 An. gambiae

CYP6N3v1     Aedes albopictus
            GenEMBL AF283836 (still confidential on July 31 2000)
            Zhou Guo-li
            62% identical to CYP6N1 over the full length sequence
            submitted to nomenclature committee July 31, 2000

CYP6N3v2     Aedes albopictus
            GenEMBL AF283837 (still confidential on July 31 2000)
            Zhou Guo-li
            3 diffs with CYP6N3v1 over the full length sequence
            submitted to nomenclature committee July 31, 2000

CYP6N3v3     Aedes albopictus
            GenEMBL AF283838 (still confidential on July 31 2000)
            Zhou Guo-li
            4 diffs with CYP6N3v1 over the full length sequence
            submitted to nomenclature committee July 31, 2000

CYP6N3v4     Aedes albopictus
            GenEMBL AF284783 (still confidential on July 31 2000)
            Zhou Guo-li
            2 diffs with CYP6N3v1 over partial sequence
            submitted to nomenclature committee July 31, 2000

CYP6N4v1     Aedes albopictus
            GenEMBL AF284782 (still confidential on July 31 2000)
            Zhou Guo-li
            83% to CYP6N3v1 over partial sequence (missing heme-end)
            60% to 6N1 and 60% to 6N2 
            submitted to nomenclature committee July 31, 2000

CYP6N4v2     Aedes albopictus
            GenEMBL AF284784 (still confidential on July 31 2000)
            Zhou Guo-li
            3 diffs with CYP6N4v1 over partial sequence
            submitted to nomenclature committee July 31, 2000

CYP6N4v3     Aedes albopictus
            GenEMBL AF284785 (still confidential on July 31 2000)
            Zhou Guo-li
            1 diff with CYP6N4v2 over partial sequence
            submitted to nomenclature committee July 31, 2000

CYP6N4v4     Aedes albopictus
            GenEMBL AF284786 (still confidential on July 31 2000)
            Zhou Guo-li
            5 diffs with CYP6N4v2 over partial sequence
            submitted to nomenclature committee July 31, 2000

CYP6N4v5     Aedes albopictus
            GenEMBL AF284787 (still confidential on July 31 2000)
            Zhou Guo-li
            4 diffs with CYP6N4v2 over partial sequence
            submitted to nomenclature committee July 31, 2000

CYP6N4v6    Aedes albopictus 
            GenEMBL AF284788 (still confidential on July 31 2000)
            Zhou Guo-li
            6 diffs with CYP6N4v2 over partial sequence
            submitted to nomenclature committee July 31, 2000

CYP6N5X     Aedes aegypti (yellow fever mosquito)
            Note: 6N5 is the same seq as CYP6N1

CYP6N6      Aedes aegypti (yellow fever mosquito)

CYP6N6v1    Aedes aegypti (mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T1.4

CYP6N6v2    Aedes aegypti (mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I2.2

CYP6N7      Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427077.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 14
            66% to CYP6N4v6, 65% to CYP6N3v1
            partial seq, 84 aa EXXR to heme

CYP6N8      Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427073.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone1-5
            61% to CYP6N7
            partial seq, 84 aa EXXR to heme

CYP6N9      Aedes aegypti (yellow fever mosquito)

CYP6N10P    Aedes aegypti (yellow fever mosquito)

CYP6N11     Aedes aegypti (yellow fever mosquito)

CYP6N12     Aedes aegypti (yellow fever mosquito)

CYP6N13     Aedes aegypti (yellow fever mosquito)

CYP6N14     Aedes aegypti (yellow fever mosquito)

CYP6N15     Aedes aegypti (yellow fever mosquito)

CYP6N16     Aedes aegypti (yellow fever mosquito)

CYP6N17     Aedes aegypti (yellow fever mosquito)

CYP6N18    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 33
           75% to 6N16 Aedes, 74% to 6N2 Anoph.

CYP6N18    Culex pipiens

CYP6N19    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 31
           68% to 6N11 Aedes, 57% to 6N1v2 Anoph.

CYP6N19    Culex pipiens

CYP6N20    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 28
           55% to 6N1v2 Anoph., 67% to 6N9 Aedes

CYP6N20v1  Culex pipiens

CYP6N20v2  Culex pipiens

CYP6N21P   Culex pipiens

CYP6N22    Culex pipiens

CYP6N23    Culex pipiens

CYP6N24    Culex pipiens

CYP6N25    Culex pipiens

CYP6N26P   Culex pipiens

CYP6N27P   Culex pipiens

CYP6P1      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 7G05
            44% identical to CYP6A5

CYP6P1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r7

CYP6P1      Anopheles funestus
            No accession number
            Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson, 
            Lizette Koekemoer, on Sept. 9, 2004
            82% identical to A. gambiae CYP6P1 I-helix to heme
            this is the presumed ortholog to CYP6P1
            other 6P sequences are much less similar

CYP6P1      Anopheles funestus
            No accession number
            Charles Wondji
            submitted to nomenclature committee 6/25/12
            81% to CYP6P1 An. gambiae, 
            88% to CYP6P8 An. minimus probable ortholog

CYP6P2      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 1/31/02
            clone name P2
            61% identical to CYP6P1

CYP6P2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r8

CYP6P2      Anopheles funestus
            No accession number
            Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson, 
            Lizette Koekemoer, on Sept. 9, 2004
            84% identical to A. gambiae CYP6P2 I-helix to heme
            this is the presumed ortholog to CYP6P2 A. gambiae
            other 6P sequences are much less similar

CYP6P2      Anopheles funestus
            No accession number
            Charles Wondji
            submitted to nomenclature committee 6/25/12
            82% to CYP6P1 An. gambiae, 
            89% to CYP6P7 An. minimus probable ortholog

CYP6P3      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 1/31/02
            clone name 17d17
            55% identical to CYP6P1

CYP6P3      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r4

CYP6P4      Anopheles gambiae (mosquito)
            no accession number
            Dimitra Nikou
            submitted to nomenclature committee 2/25/02
            clone name 18M16 
            64% to 6P3 missing C-term

CYP6P4      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r6

CYP6P4      Anopheles funestus (mosquito)
            no accession number
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            submitted to nomenclature committee 11/17/04
            submitted name sequence 3, 126 aa fragment
            89% identical to CYP6P4 Anopheles gambiae probable ortholog
            1 aa diff to CYP6P4b Anopheles funestus
            4 aa diffs to CYP6P4a Anopheles funestus

CYP6P4a     Anopheles funestus
            No accession number
            Charles Wondji
            submitted to nomenclature committee 6/25/12
            85% to CYP6P1 An. gambiae
            CYP6P4a and CYP6P4b are tandem duplicates 95% identical

CYP6P4b     Anopheles funestus
            No accession number
            Charles Wondji
            submitted to nomenclature committee 6/25/12
            85% to CYP6P1 An. gambiae
            CYP6P4a and CYP6P4b are tandem duplicates 95% identical

CYP6P5      Anopheles gambiae (mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            77% to 6P3

CYP6P5      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r5

CYP6P5      Anopheles funestus (mosquito)
            no accession number
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            submitted to nomenclature committee 11/17/04
            submitted name sequence 2
            88% identical to CYP6P5 Anopheles gambiae probable ortholog

CYP6P5      Anopheles funestus
            No accession number
            Charles Wondji
            submitted to nomenclature committee 6/25/12
            90% to CYP6P5 An. gambiae (complete seq)

CYP6P6      Anopheles minimus
            GenEMBL AY128947
            This sequence was named incorrectly by the author as CYP6P5
            but that was not an official name, so it has been changed.
            84% to CYP6P3

CYP6P7      Anopheles minimus
            No accession number
            Rongnoparut, P. 
            Submitted to nomenclature committee October 17, 2003
            Clone name minimus 1
            81% to CYP6P2
            note this is the ortholog of CYP6P2 An. Gambiae and An. Funestus
            It may be best to rename this seq CYP6P2 to indicate that.

CYP6P8      Anopheles minimus
            No accession number
            Rongnoparut, P. 
            Submitted to nomenclature committee October 17, 2003
            Clone name minimus 2
            79% to CYP6P1

CYP6P9a    Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           Tandem duplication with CYP6P9bv1 (94% identical)
           95% to CYP6P9bv3 Anopheles funestus
           93% to CYP6P9bv2 (old CYP6P13) Anopheles funestus
           89% to CYP6P6 An. minimus probable co-ortholog

CYP6P9bv1  Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           98% to CYP6P9bv2 (old CYP6P13) Anopheles funestus
           97% to CYP6P9bv3 Anopheles funestus
           94% to CYP6P9a   Anopheles funestus (adjacent gene)
           92% to CYP6P6    An. minimus probable co-ortholog

CYP6P9bv2  Anopheles funestus 
           Formerly CYP6P13
           No accession number
           Tonderayi Matambo, Lizette Koekemoer 
           submitted to nomenclature committee 12/13/07
           complete seq
           98% to CYP6P9bv1 Anopheles funestus
           97% to CYP6P9bv3 Anopheles funestus EU852650
           93% to CYP6P9a full seq., 90% to 6P6
           name changed from CYP6P13 to CYP6P9bv2

CYP6P9bv3  Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 6/14/04
           CYP6 Contig 1, aa 327-451 (only 125 aa long)
           86% to 6P3, 83% to 6P5
           note: there are two 6P9 genes 94% identical by tandem duplication
           This seq is CYP6P9bv3 and the other is CYP6P9a
           These are co-orthologs to An. gambiae CYP6P3 and An. minimus CYP6P6

CYP6P9bv3  Anopheles funestus 
           EU852650
           Tonderayi Matambo, Lizette Koekemoer 
           submitted to nomenclature committee 12/13/07
           nearly complete seq, one aa diff to partial seq of 125 aa
           97% to to CYP6P9bv1 Anopheles funestus
           97% to to CYP6P9bv2 (old CYP6P13) Anopheles funestus
           95% to CYP6P9a Anopheles funestus
           84% to 6P3

CYP6P10v1  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY948075
           Shaoming Huang
           Submitted to nomenclature committee Feb. 21, 2005
           Clone name sample 1
           65% to CYP6P4

CYP6P10v2  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY948076
           Shaoming Huang
           Submitted to nomenclature committee Feb. 21, 2005
           Clone name sample 2
           98.6% to CYP6P10v1

CYP6P10v3  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY948077
           Shaoming Huang
           Submitted to nomenclature committee Feb. 21, 2005
           Clone name sample 3
           98.4% to CYP6P10v2

CYP6P10v4  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY948078
           Shaoming Huang
           Submitted to nomenclature committee Feb. 21, 2005
           Clone name sample 5
           99% to CYP6P10v3

CYP6P10v5  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY948079
           Shaoming Huang
           Submitted to nomenclature committee Feb. 21, 2005
           Clone name sample 6
           99% to CYP6P10v4

CYP6P10v6   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427074.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 9
            77% to CYP6P4, 1aa diff to CYP6P10v5
            partial seq, 84 aa EXXR to heme

CYP6P10v7   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427078.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 17
            1aa diff to CYP6P10v6
            partial seq, 84 aa EXXR to heme

CYP6P10v8   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427079.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 18
            3aa diffs to CYP6P10v6
            partial seq, 84 aa EXXR to heme

CYP6P10v9   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427080.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 19
            3aa diffs to CYP6P10v6
            partial seq, 84 aa EXXR to heme

CYP6P10v10  Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427081.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 21
            1aa diff to CYP6P10v6
            partial seq, 84 aa EXXR to heme

CYP6P11     Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427084.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 26
            66% to CYP6P3, 63% to 6P6
            partial seq, 84 aa EXXR to heme

CYP6P12v1   Aedes aegypti (yellow fever mosquito)

CYP6P12v2   Aedes aegypti (yellow fever mosquito)

CYP6P13X   Anopheles funestus 
           No accession number
           Tonderayi Matambo, Lizette Koekemoer 
           submitted to nomenclature committee 12/13/07
           complete seq
           93% to CYP6P9a full seq., 90% to 6P6
           name changed to CYP6P9bv2

CYP6P14    Culex pipiens

CYP6P15P    Anopheles funestus
            No accession number
            Charles Wondji
            submitted to nomenclature committee 6/25/12
            between CYP6AA2 and CYP6P9a
            the most conserved region (before the PERF motif)
            is 70% to CYP6P2 so this is probably a CYP6P pseudogene

CYP6P16     Anopheles sinensis
            No accession number
            Yanfei 
            Submitted to nomenclature committee 7/4/2013
            80% to CYP6P5 A. funestus
            78% to CYP6P5 A. gambiae
            76% to CYP6P9bv1 A. funestus

CYP6Q1X     Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 04I gene A
            46% identical to CYP6A1 and 6E1 52% to 6N1
            renamed CYP6N2 based on close sequence similarity to 6N3 and 6N4 sequences

CYP6R1      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 04I gene B
            43% identical to CYP6Q1

CYP6R1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r3

CYP6R1     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           68% to CYP6R1 An. gambiae

CYP6S1      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 8/9/99
            clone name 04I gene C
            45% identical to CYP6A1

CYP6S1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r2

CYP6S1     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           83% to CYP6S1 An. gambiae

CYP6S2      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 10/15/2001
            clone name 24H06
            72% identical to CYP6S1

CYP6S2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r1

CYP6S2     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           82% to CYP6S2 An. gambiae

CYP6S3      Aedes aegypti (yellow fever mosquito)

CYP6S4      Culex_quinquefasciatus (southern house mosquito)
            No accession number
            Osamu Komagata
            submitted to nomenclature committee 7/25/07
            sequence 27
            77% to 6S3 Aedes, 66% to 6S1 Anopheles

CYP6S4     Culex pipiens

Cyp6t1      Drosophila melanogaster
            GenEMBL AC012831 comp(42975-44564) no introns

Cyp6t1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6t2p     Drosophila melanogaster
            GenEMBL AC014742 1042-2504

Cyp6t3      Drosophila melanogaster
            GenEMBL AC015208 comp(17123-18689)

Cyp6t3      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6u1      Drosophila melanogaster
            GenEMBL AC017706 15959-17471 also AC008288

Cyp6u1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6v1      Drosophila melanogaster
            GenEMBL AC011761 comp(54926-57766) also AC015002

Cyp6v1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp6w1      Drosophila melanogaster
            GenEMBL AC014226 comp(15025-16689) also AC008257

Cyp6w1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP6X1v1    Lygus lineolaris (Heteroptera:  Miridae) Lygus bug
            GenEMBL AY054411.1|
            Yu Cheng Zhu
            Submitted to nomenclature committee 8/17/01
            CYP42% to CYP6N sequences, 41% to CYP6S, 40% to CYP6P sequences
            40% to some CYP6A sequences, 40% to CYP6F 
            Pyrethroid susceptible strain

CYP6X1v2    Lygus lineolaris (Heteroptera:  Miridae) Lygus bug
            GenEMBL AY054412.1|
            Yu Cheng Zhu
            Submitted to nomenclature committee 8/17/01
            CYP42% to CYP6N sequences, 41% to CYP6S, 40% to CYP6P sequences
            40% to some CYP6A sequences, 40% to CYP6F 
            Pyrethroid resistant strain (0ne amino acid difference to 6X1v1)

CYP6X1v3    Lygus lineolaris (Heteroptera:  Miridae) Lygus bug
            GenEMBL AY125086
            Yu Cheng Zhu
            Submitted to nomenclature committee 6/17/02
            Clone name LRR118 99% to 6X1 v1 (2 aa differences)
            Note: clone names were reversed. Corrected on 2/9/2010

CYP6X1v4    Lygus lineolaris (Heteroptera:  Miridae) Lygus bug
            No accession number
            Yu Cheng Zhu
            Submitted to nomenclature committee 6/17/02
            Clone name LRR117 98% to 6X1v1 (6 aa differences)
            Note: clone names were reversed. Corrected on 2/9/2010

CYP6Y1      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 1/21/02
            clone name M1b
            45% identical to CYP6M1

CYP6Y1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r6

CYP6Y1      Anopheles funestus (mosquito)
            no accession number
            John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya, 
            Lizette Koekemoer
            submitted to nomenclature committee 11/17/04
            submitted name sequence 1
            85% identical to CYP6Y1 Anopheles gambiae probable ortholog

CYP6Y1     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           85% to CYP6Y1 An. gambiae

CYP6Y2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r5

CYP6Y2     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           88% to CYP6Y2 An. gambiae

CYP6Y3      Aedes aegypti (yellow fever mosquito)

CYP6Y4     Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 29
           57% to 6Y3 Aedes, 64% to 6Y2 Anoph.

CYP6Y4     Culex pipiens

CYP6Y5     Culex pipiens

CYP6Y6     Culex pipiens

CYP6Z1      Anopheles gambiae (mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 1/21/02
            clone name 18L09
            40% identical to CYP6F1 41% to CYP6D3v2

CYP6Z1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r14

CYP6Z1     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           85% to CYP6Z1 An. gambiae

CYP6Z2      Anopheles gambiae (mosquito)
            no accession number
            Dimitra Nikou
            submitted to nomenclature committee 2/25/02
            clone name 18LB 
            69% to CYP6Z1

CYP6Z2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r13

CYP6Z3      Anopheles gambiae (mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            40% to 6d5 70% to 6Z1 67% to 6Z2

CYP6Z3      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r10

CYP6Z3     Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           85% to CYP6Z3 An. gambiae

CYP6Z4      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPm3r12

CYP6Z5v1    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427067.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            CloneE1
            64% to CYP6Z2, 3aa diffs to CYP6Z5v4
            partial seq, 130 aa at C-term

CYP6Z5v2    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427068.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            CloneE2
            1aa diff to CYP6Z5v4
            partial seq, 130 aa at C-term

CYP6Z5v3    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427069.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            CloneE3
            4aa diffs to CYP6Z5v4
            partial seq, 130 aa at C-term

CYP6Z5v4    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427070.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            CloneE4
            64% to CYP6Z2
            partial seq, 130 aa at C-term

CYP6Z5v5    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427071.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            CloneE5
            2aa diffs to CYP6Z5v4
            partial seq, 130 aa at C-term

CYP6Z5v6    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427075.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 10
            3aa diffs to CYP6Z5v1
            partial seq, 83 aa EXXR to heme

CYP6Z5v7    Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427075.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 24
            2aa diffs to CYP6Z5v1
            partial seq, 83 aa EXXR to heme

CYP6Z6      Aedes aegypti (yellow fever mosquito)

CYP6Z7      Aedes aegypti (yellow fever mosquito)

CYP6Z8      Aedes aegypti (yellow fever mosquito)

CYP6Z9      Aedes aegypti (yellow fever mosquito)

CYP6Z10     Culex_quinquefasciatus (southern house mosquito)
            No accession number
            Osamu Komagata
            submitted to nomenclature committee 7/19/07
            sequence 5
            58% to CYP6Z4 Anopheles gambiae

CYP6Z10    Culex pipiens

CYP6Z11    Culex pipiens

CYP6Z12    Culex pipiens

CYP6Z13P   Culex pipiens

CYP6Z14    Culex pipiens

CYP6Z15    Culex pipiens

CYP6Z16    Culex pipiens

CYP6Z17    Culex pipiens

CYP6AA1     Anopheles gambiae (mosquito)
            no accession number
            Dimitra Nikou
            submitted to nomenclature committee 2/25/02
            clone name 29006 
            45% to 6P1 44% to 6A2 missing about 25aa at C-term

CYP6AA1     Anopheles gambiae (mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            47% to 6A2 100% to 6AA1

CYP6AA1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r1

CYP6AA1     Anopheles minimus
            GenEMBL AY129952
            This sequence was named incorrectly by the author as CYP6AA2
            but that was not an official name, so it has been changed.
            85% to CYP6AA1
            name changed from CYP6AA3
            note: recent work has shown this seq is the ortholog of CYP6AA1
            We are renaming the sequence to CYP6AA1 for this reason.

CYP6AA1     Anopheles funestus 
            No accession number
            Lizette Koekemoer 
            submitted to nomenclature committee 6/14/04
            CYP6 Contig 2, aa 323-447
            84% to 6AA1, 68% to 6AA2
            probable ortholog of 6AA1
            name changed from CYP6AA4
            note: recent work has shown this seq is the ortholog of CYP6AA1
            We are renaming the sequence to CYP6AA1 for this reason.

CYP6AA2     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r2

CYP6AA2    Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           80% to CYP6AA2 A. gambiae

CYP6AA3X    Anopheles minimus
            GenEMBL AY129952
            This sequence was named incorrectly by the author as CYP6AA2
            but that was not an official name, so it has been changed.
            85% to CYP6AA1
            note: recent work has shown this seq is the ortholog of CYP6AA1
            We are renaming the sequence to CYP6AA1 for this reason.

CYP6AA4X   Anopheles funestus 
           No accession number
           Lizette Koekemoer 
           submitted to nomenclature committee 6/14/04
           CYP6 Contig 2, aa 323-447
           84% to 6AA1, 68% to 6AA2
           probable ortholog of 6AA1
           note: recent work has shown this seq is the ortholog of CYP6AA1
           We are renaming the sequence to CYP6AA1 for this reason.

CYP6AA5v1   Aedes aegypti (yellow fever mosquito)

CYP6AA5v2   Aedes aegypti (yellow fever mosquito)

CYP6AA6     Aedes aegypti (yellow fever mosquito)

CYP6AA7     Culex pipiens

CYP6AA8     Culex pipiens

CYP6AA9     Culex pipiens

CYP6AB1     Trichoplusia ni Family: Noctuidae (caterpillar) 
            No accession number
            Ping Wang
            38% to 6F1 39% to 6a2 (sequence 1)
            submitted to nomenclature committee 5/20/02
            54% to 6AB2 58% to 6AB3

CYP6AB2     Trichoplusia ni Family: Noctuidae (caterpillar) 
            No accession number
            Ping Wang
            38% to 6B9, 38% to 6a2 (sequence 4)
            submitted to nomenclature committee 5/20/02
            formerly 6AC1 renamed CYP6AB2 54% identical to 6AB1 56% to 6AB3

CYP6AB3v1  Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
            AY295773.1
            Weimin Li and May Berenbaum
            submitted to nomenclature committee 10/15/02
            58% to 6AB1, 56% to 6AB2 
            clone name heme1

CYP6AB3v2  Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
           EF111024.1

CYP6AB4    Bombyx mori (silkworm)
           BAAB01081811.1 BAAB01162324.1 BAAB01031011.1
           EF017798 (4 aa diffs to BAAB accessions), EF415299
           64% TO 6AB1
           See silkworm page for sequence

CYP6AB4    Bombyx mandarina
           DQ993198
           8 aa diffs to CYP6AB4 Bombyx mori

CYP6AB5    Bombyx mori (silkworm)
           BAAB01021567.1 BAAB01206787.1
           56% TO 6AB4
           See silkworm page for sequence

CYP6AB5    Bombyx mandarina
           FJ795021
           95% to CYP6AB5 B. mori

CYP6AB6    Papilio multicaudatus
           No accession number
           Wenfu Mao and May Berenbaum
           submitted to nomenclature committee 11/1/05
           62% to 6AB4

CYP6AB7     Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
            EF111023.1
            Wenfu Mao and May Berenbaum
            submitted to nomenclature committee 12/28/05
            88% to 6AB3, 57% to 6AB1 
            clone name C-1

CYP6AB8     Bombyx mori (silkworm)
            AADK01010774.1
            See silkworm page for details

CYP6AB9     Helicoverpa armigera (cotton bollworm)
            JN176570 (3 aa diffs)
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_217 64% to CYP6AB4 Bombyx
            Contig_161 has 1 aa diff to Contig_217

CYP6AB10.a  Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_164 N-terminal half
            87% to CYP6AB2, 53% to CYP6AB9, 50% to CYP6AN1
            HAH006987_2 is 100% to Contig_164

CYP6AB10.b  Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_196 C-terminal half
            opp end of 6AB10.a? Whole seq is 54% to CYP6AB9
            Contig_195 has 4 aa diffs to Contig_196 
            85% to CYP6AB2, 54% to 6AB9, 56% to 6AN1

CYP6AB11    Amyelois transitella (Navel orangeworm)
            No accession number 
            Guodong Niu
            submitted to nomenclature committee May 22, 2008
            65% to CYP6AB4

CYP6AB12    Spodoptera frugiperda (a moth)
            KC789747
            Rene Feyereisen
            Submitted to nomenclature committee Nov. 21, 2008
            60% to CYP6AB1 Trichoplusia ni, 
            75% to CYP6AB9 Helicoverpa armigera

CYP6AB13   Manduca sexta 
           GU731534
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6AB14   Spodoptera litura
           JF829002
           Zihbin Xu, Sichun Zheng, Qili Feng
           submitted to nomenclature committee April 17, 2011
           70% to CYP6AB4 Bombyx mori

CYP6AB14    Spodoptera littoralis (cotton leafworm)
            JX310081
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            98% to CYP6AB14 Spodoptera litura (probable ortholog)

CYP6AB15    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            61% to CYP6AB7 Depressaria pastinacella

CYP6AB16    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            63% to CYP6AB13 Manduca sexta

CYP6AB17    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            66% to CYP6AB13 Manduca sexta

CYP6AB18    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            54% to CYP6AB7 Depressaria pastinacella

CYP6AB19v1  Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            89% to CYP6AB9 Helicoverpa armigera

CYP6AB19v2  Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            99% to CYP6AB19v1 Heliothis subflexa

CYP6AB19    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            98% to CYP6AB19v2 Heliothis subflexa

CYP6AB20    Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011

CYP6AB20    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            98% to CYP6AB20 Heliothis subflexa

CYP6AB21    Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            85% to CYP6AB2 Trichoplusia ni

CYP6AB21    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            97% to CYP6AB21 Heliothis subflexa

CYP6AB22    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            79% to CYP6AB14 Spodoptera litura

CYP6AB23    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            84% to CYP6AB19v1 Heliothis subflexa

CYP6AB24    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            95% to CYP6AB17 Heliconius melpomene

CYP6AB25    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            69% to CYP6AB14 Spodoptera litura

CYP6AB26    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            65% to CYP6AB14 Spodoptera litura

CYP6AB27    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            56% to CYP6AB14 Spodoptera litura

CYP6AB28   Plutella xylostella 
           Gene number CCG004643.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           61% TO CYP6AB7 Depressaria pastinacella
           MISSING 4 AA AT HEME SIGNATURE

CYP6AB29    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 14, 2012
            90% to CYP6AB15 Heliconius melpomene

CYP6AB30    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 14, 2012
            82% to CYP6AB27 Heliconius melpomene

CYP6AB31    Spodoptera littoralis (cotton leafworm)
            JX310080
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            81% to CYP6AB23 Heliothis virescens

CYP6AB32   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AB33   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AB34   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AB35   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AB36   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AB37   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AB38   Helicoverpa armigera (cotton bollworm)

CYP6AB39   Amyelois transitella (Navel orangeworm)
CYP6AB40   Amyelois transitella (Navel orangeworm)
CYP6AB41   Amyelois transitella (Navel orangeworm)
CYP6AB42   Amyelois transitella (Navel orangeworm)
CYP6AB43   Amyelois transitella (Navel orangeworm)
CYP6AB44   Amyelois transitella (Navel orangeworm)

CYP6AB45   Chilo suppressalis (striped rice stem borer)
CYP6AB46   Chilo suppressalis (striped rice stem borer)
CYP6AB47   Chilo suppressalis (striped rice stem borer)
CYP6AB48   Chilo suppressalis (striped rice stem borer)
CYP6AB49   Chilo suppressalis (striped rice stem borer)
CYP6AB50   Chilo suppressalis (striped rice stem borer)
CYP6AB51   Chilo suppressalis (striped rice stem borer)
CYP6AB52   Chilo suppressalis (striped rice stem borer)
CYP6AB53   Chilo suppressalis (striped rice stem borer)

CYP6AB54   Manduca sexta (tobacco hornworm)
CYP6AB55   Agrotis ipsilon 
           JQ901386
           85% to CYP6AB10

CYP6AB56   Mamestra brassicae 
           JQ901385
           88% to CYP6AB2

CYP6AC1X    Trichoplusia ni Family: Noctuidae (caterpillar) name discontinued
            No accession number
            Ping Wang
            38% to 6B9, 38% to 6a2 (sequence 4)
            submitted to nomenclature committee 5/20/02
            renamed CYP6AB2 54% identical to 6AB1 56% to 6AB3

CYP6AD1     Anopheles gambiae (malaria mosquito)
            no accession number
            Rene Feyereisen
            submitted to nomenclature committee 7/5/02
            42% to 6P1

CYP6AD1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPf2r9

CYP6AD1    Anopheles funestus
           No accession number
           Charles Wondji
           submitted to nomenclature committee 6/25/12
           80% to CYP6AD1 A. gambiae

CYP6AE1     Depressaria pastinacella (Lepidoptera: Oecophoridae)  (parsnip webworm)
            No accession number
            Weimin Li and May Berenbaum
            submitted to nomenclature committee 10/15/02
            38% to 6AB2
            clone name C4-31

CYP6AE2     Bombyx mori (silkworm)
            No accession number
            Junwen Ai
            submitted to nomenclature committee Jan. 31, 2007
            nearly identical to sequence CYP6AEcc on Bombyx page except
            one region from amino acids 106-256 does not match.
            The EST BY914225 agrees with this sequence so the CYP6AEcc sequence 
            appears to be a hybrid assembled from two genes.

CYP6AE3P    Bombyx mori (silkworm)
            Matches CYP6AEbb except for a short middle region
            This part of 6AEbb matches 6AE2
            96% to CYP6AE2
            See silkworm page for sequences

CYP6AE4     Bombyx mori (silkworm)
            Matches CYP6AEaa
            See silkworm page for sequences

CYP6AE5     Bombyx mori (silkworm)
            Matches CYP6AEff
            See silkworm page for sequences

CYP6AE6P    Bombyx mori (silkworm)
            Matches CYP6AEee
            See silkworm page for sequences

CYP6AE7     Bombyx mori (silkworm)
            Matches CYP6AEdd
            See silkworm page for sequences

CYP6AE7     Bombyx mori strain Laos
            GenEMBL EF432656
            Dong Wang
            submitted to nomenclature committee Oct. 2, 2007
MILTIIFILSLCVYILYRISTRKFDYWQKKNVSYVEPAPFLGNY
SGYILLKENLLDVVHNLSKLFPNDPYVGAFFGTKPTLIVKDPEFIKLVLIKDFYYFHG
REGSKYTHNEVITQGIFFTYGDRWKVIRQNLTPLFSSSKIRNMFRTIEKCSGVFENLL
DEESLAPEVEMRSVMSRFTMDCIGGCAFGVDTNAMQEPKDNIFKTMGYLFFESTTRRG
IKNVFKAIWPEIFYGLGFKVFPTDLNEFFSKLLVGIFEARDYKPSSQNVFINLLLNLK
KNRHIVGDRLLKIKTGNVRAESKIKLEVDDELLVSQCVAFFIAGFETSSTISRFTLYE
LAKNPDVQKRAQKEVDEYIKKHNNKLDYDCVKELPFVEACIDEALRLYPVLGVLTREV
MEQYTFPTGLTLDKGDRVHIPVYHLHRDPEYFPEPELFKPERFCGEEKRNIRPFTYLP
FGAGPRTCIGQRFAKMQMLAGLVTILKRYTVCLAEGMPETINFEQRAIVTQPNIGIRL
NLLPRNN

CYP6AE8X    Bombyx mori (silkworm)
            Matches CYP6AEgg
            See silkworm page for sequence
            Note: this sequence has had a name change from CYP6AE8 to CYP6AE9v2

CYP6AE8     Bombyx mori strain Laos
            GenEMBL EF528486
            Dong Wang
            submitted to nomenclature committee Oct. 2, 2007
MSVSAVVFAAFVLLVTYIYYWSTRKFDYWKRKNVPYAKPVPFFG
NYMRYITLQSYIGDVTQKLCQQFPDRPYFGSFYGTEPALVLQNPEIIKQVFTKDFYYF
NSRENSDYNHKEIVTQNLFFANGDKWKVVRQNLTPLFSSLKMKNMFYLVEKCNHSLED
MLDKEIKDLQIIEIRSAMIRYTLDSICSSAFGIESNTLSEGGENSPFANMGSIVFSSS
ITRGLKWISRSMWPGIFYKLGLQCFPAEIDGFFERVLTEVFENRGYKPTNRNDFVDLI
LSLKQNDYLTGDGLVPKNMDAKKVTVKVDDALLIAQCVVFFGAGFETSASTLSAALYE
PAKNPEAQRRAQEEVDELLLKHNNKLNYDCLAELPYLEACMNEAMRLYPVLPNITREA
VADYTFPDGLRIEKGMRVHVPVYAIHRNPDNFPDPEEFRPERHLGDAKNDIKQFTFFP
FGEGPRICIGMRFGKMQTIAGMVTCLKKYNFELADGMSKTVPFRSTTVLTQPSTGLFL
KATPRDGWKQRIFAR

CYP6AE9X    Bombyx mori (silkworm)
            Matches Cyp6AEhh
            See silkworm page for sequences
            Note: this sequence has had a name change from CYP6AE9 to CYP6AE22v2

CYP6AE9v1   Bombyx mori strain Laos
            GenEMBL EF535809
            Dong Wang
            submitted to nomenclature committee Oct. 2, 2007
MFLLINICVILFVIYYLVTKKYSYWRNRNVSHEKPVLLLGNYGD
LILQKKNFGEMARAICQKFPGEPVVGAFFGTEPVLIPQDPEVIKTILTKDFYYFNGRE
ISEHVHKELLSYNLFATYRDEWKILRQNLTPIFSTAKLKSMFTLIEKCSKSFQNLLED
ETKISKELEVRTLMQRFTIECIGSCIFGVDTDTLGNDKMNPFKAAGSQLSDFSRLVFV
KGIVRAIWPTLFYALGFKTFTTELDIFKKLVNAVFAQRKHKPTTRNDFVDLILTWKNN
NTITGDSIGSFKNSDKTKFSIDVNDDLLLAQCLVFFAAGFETSAMTSSYTLHELAKNQ
RALKKACDEVDAYLLRHGNKINYDCVTELPYLEACIEETLRLYPVLGIITREVMEDYV
LLDKIHLKKGDRIHVPVFHLHHNPEHFPNPEEYRPERFYGEEKRKVKPYTYLPFGEGP
RICIGMRFAKMQSIAGLITILKKFRLELPEGAPTKIEFKPEAFVTTPKDLIKIKFLER
EGWQQRVFV

CYP6AE9v2   Bombyx mori (silkworm)
            Matches CYP6AEgg
            See silkworm page for sequence
            Note: this sequence has had a name change from CYP6AE8 to CYP6AE9v2

CYP6AE10    Spodoptera exigua (beet armyworm)
            No accession
            Katsuya Natsuhara
            Submitted to nomenclature committee July 26, 2004
            56% to 6AE1

CYP6AE11    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            100% identical to Heckels seq.

CYP6AE11    Helicoverpa armigera (cotton bollworm)
            No accession number
            David G. Heckel 
            submitted to nomenclature committee Feb. 21, 2005
            HaCypZ018a-v1Pep 
            58% to 6AE1 66% to 6AE10

CYP6AE11    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH003743 100% to CYP6AE11
            Contig_207 has 4 aa diffs to HAH003743

CYP6AE12v1  Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            98% (9 aa diffs) to 6AE12v2

CYP6AE12v1  Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_150 100% to CYP6AE12v1 from Rene Feyereisen

CYP6AE12v2  Helicoverpa armigera (cotton bollworm)
            GenEMBL DQ256407
            Yidong Wu and Lina Yue
            submitted to nomenclature committee Aug. 13, 2005
            clone name YS-6a
            67% to CYP6AE11

CYP6AE13    Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee Dec. 10, 2005
            Clone name sequence 3 NR3 fragment (C-terminal)
            63% to 6AE12

CYP6AE14    Helicoverpa armigera (cotton bollworm)
            No accession number
            Ying-Bo Mao
            Submitted to nomenclature committee Sept. 15, 2006
            Clone name GIP (Gossypol Inducible P450)
            90% to CYP6AE11

CYP6AE14    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_206, 2 aa diffs to CYP6AE14 from Ying-Bo Mao
            90% to contig _207 (6AE11)

CYP6AE15v1  Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            74% to CYP6AE12 

CYP6AE15v1  Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH002367 has 4 aa diffs to Contig_184 CYP6AE15v2
            100% to CYP6AE15v1 from Rene Feyereisen

CYP6AE15v2  Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_184 4 aa diffs to CYP6AE15v1

CYP6AE16    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            83% to CYP6AE11 

CYP6AE17    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            73% to CYP6AE11 

CYP6AE17    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_175 has 3 aa diffs to CYP6AE17 from Rene Feyereisen
            HAH001433 is 100% to Contig_175
            Contig_223 has 4 aa diffs to Contig_175

CYP6AE18    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            72% to CYP6AE11 

CYP6AE19    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            56% to CYP6AE11 

CYP6AE19    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_224 100% to CYP6AE19 from Rene Feyereisen
            89% to Contig_160 CYP6AE20v2, 90% to HAH000205 CYP6AE23

CYP6AE20v1  Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            56% to CYP6AE11 

CYP6AE20v2  Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_160 has 3 aa diffs to CYP6AE20v1 
            including an internal stop codon (not in HAH012568)
            HAH012568 has 1 aa diff to Contig_160 at an internal stop codon

CYP6AE21    Bombyx mori strain Laos
            GenEMBL EF432657
            Dong Wang
            submitted to nomenclature committee Oct. 2, 2007
            94% to CYP9AE3P 
MSVSALVFAAFVLLVTYIYYWSTRKFEYWKRKNVPYAKPVPFFG
NYMRYITLQSYIGDVMQKLCQQFPDRPYFGSFYGTEPALVLQNPEIIKQVFTKDFYYF
NSRDNSDYNHKEVVTQNLFFANGDKWKVVRQNLTPLFSSSKMKNMFYLVEKCNHSLED
MLDRETKDLQIIEIRAAMIRYTLDSICSSAFGIETNTLSEGGEYSPFANMASIIFSPS
IARGLKWISRSMWPGIFYKLGLQCFPAEIDDFFERLLTEVFENRGCKPTNRNDFVDLI
LSLKQNDYLTGDGLVPKNVDAKKVTVKVDDALLIAQCVVFFGAGFETSATTLSAALYE
LAKNPEAQRRAQEEVDELLLKHNNKLNYDCLAELPYLEACMNEAMRLYPVFPNITRET
VADYTFPDGLRIDKGMRVHVPVYAIHRNPDNFPDPEEFRPERYLGDAKNDIKQFTFFP
FGEGPRICIGMRFGKMQTIAGLITCLKKFNFELADGMPRTLAFRSTTLLTQLSTGLFL
KATPRDGWEQRIFAR

CYP6AE22v1  Bombyx mori strain Laos
            GenEMBL EF528485
            Dong Wang
            submitted to nomenclature committee Oct. 2, 2007
            4 amino acid differences to CYP6AE22v2
MYVLTFLLHFILFLVLVVYYITKRNHDYWKNKKVPFEKPYPILG
NYGDYILLKIFFGNVTKRLCEKFPESPYVGTFYGTEPALVVQDPDLIRLILVKDFFYF
HGREVCIYVDREITTQSIFFTYGDDWRVLRHSLTPLFTTSKMKNMFHLIKNCCRVFEN
VLEEKATVKSFEINSIIKYFIMDCVGACLFGVEINAMEKHSQNPIVKISKEIFPKSTT
RGIINVLRGIWPSLFYALRLKLFPEVITMFFTDLLECAFKDRQRNLSQRQDFIDLFMK
LRQNKYLVGDSIPDIKNGRVQKVNLEVTDELLIAQCVSFFGAAFETSSTTLSLTFYEL
AKNPKYQKRAIEEVDDYFAKHNNEIEFDIVSETPYLNACIDETLRLYPSLANLTREVM
EDYTFPTGLKVEKGTRIHIPVYHLQRNPKYFPEPNKFDPRRFLPEAKQTIYPFTYMPF
GEGHRICIAMRFAKMQMLAGFATLLKKYEVAVDDTTPQELTIDPRIIVTTPIENIQLK
LIARQHAL

CYP6AE22v2  Bombyx mori (silkworm)
            Matches Cyp6AEhh
            See silkworm page for sequences
            Note: this sequence has had a name change from CYP6AE9 to CYP6AE22v2

CYP6AE23    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH000205 
            95% to Contig_160 CYP6AE20v2
            96% to CYP6AE20

CYP6AE24    Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_169 57% to CYP6AE8 Bombyx, 
            56% to CYP6AE12 Helicoverpa armigera
            HAH003329 has 3 aa diffs to Contig_169

CYP6AE25    Ostrinia furnacalis (Asian corn borer)
            No accession number
            Fengshan Yang 
            The same seq. was also submitted on Jan 5, 2009 by Yuliang Zhang
            submitted to nomenclature committee Feb. 16, 2009
            59% to Cyp6ae12

CYP6AE26    Epiphyas postvittana (Light brown apple moth)
            EV813520 EST from male antennae
            56% to CYP6AE12v1
MVLVASCRLILGTLVALAVAIGYLIL
SHKYSFWKRYGLPTPKHLPLLGNYADFILMRKNLGDTFTEICKQLPNEPIIGTYYGTEPA
VVVKDPELLKLIITKDFYYFSSRELRDHVHKETSTKNVFSAEGDYWRVIRQNLTPVFSSA
KMKKMFHLIQKRTAEYEKVLAKEIRENPIHDARSFNTRFTMDCIGSCMFGVDTNAMSSAA
NENPFRIISDKILDFSPLKLSKVIFRSIFPTIFYALKMEAFPKEANVFFEDLVKNVFKDR
NYKPGSRNDFVDFMLSFKQNDYLEGDEIKSLKIKDGSTGKIKLSVDDEMLVAQCLVFFAA
GFETSTATMSFTLYELAKKPEVLQKVLDEVDEHMKKHDGKITYDCVTELPYLEACIDESL
RLYPVLGGLTREVIEDYTLPSGVVLKKGVRVHIPVYYLQKHPDYFPEPEDYRPERFLGEN
KQDIKPFTYYPFGEGPRICIGMRFARMQMMAGLVTLLKDYTVELPPSTPRQVTFTPHAFT
TQTKEELKLKFLPRRVLAA*

CYP6AE27   Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_ c6669 
           51% to 6AE8 Bombyx, 52% to CYP6AE11 Helocoverpa armigera, 
           a probable ortholog to the CYP6AE subfamily of moths

CYP6AE28   Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
           No accession number
           Zhifan Yang
           Submitted to nomenclature committee April 13, 2009
           clone name: CM6-1
           56% to 6AE12 Helicoverpa armigera
           55% to CYP6AE1 AY295774 Depressaria pastinacella parsnip webworm

CYP6AE29   Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6AE30   Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
           No accession number
           Zhifan Yang
           submitted to nomenclature committee Aug. 13, 2009
           52% to CYP6AE28 

CYP6AE31   Manduca sexta
           No accession number
           Yannick Pauchet

CYP6AE32   Manduca sexta
           No accession number
           Yannick Pauchet

CYP6AE33    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            47% to CYP6AE12v1 Helicoverpa armigera

CYP6AE34    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            48% to CYP6AE32 Manduca sexta

CYP6AE35    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            49% to CYP6AE32 Manduca sexta

CYP6AE36    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            56% to CYP6AE9v1 Bombyx mori

CYP6AE37    Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            78% to CYP6AE17 Helicoverpa armigera

CYP6AE38    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011

CYP6AE39    Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            85% to CYP6AE17 Helicoverpa armigera

CYP6AE40    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            55% to CYP6AE33 Heliconius melpomene

CYP6AE41    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            54% to CYP6AE33 Heliconius melpomene

CYP6AE42    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            53% to CYP6AE33 Heliconius melpomene

CYP6AE43    Spodoptera frugiperda (a moth)
            No accession number
            Rene Feyereisen
            Submitted to nomenclature committee Aug. 1, 2011
            63% to CYP6AE23 Helicoverpa armigera

CYP6AE44    Spodoptera frugiperda (a moth)
            No accession number
            Rene Feyereisen
            Submitted to nomenclature committee Aug. 1, 2011
            87% to CYP6AE10 Spodoptera exigua

CYP6AE45   Plutella xylostella 
           Gene number CCG003246.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Complete, 86% to CCG017253.1
           55% to CYP6AE12v1 Helicoverpa armigera

CYP6AE46   Plutella xylostella 
           Gene number CCG017253.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Probably missing first 23 aa 

CYP6AE47    Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            75% to CYP6AE24 Helicoverpa armigera

CYP6AE48    Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            88% to CYP6AE10 Spodoptera exigua

CYP6AE49    Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            80% to CYP6AE43 Spodoptera frugiperda

CYP6AE50    Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            62% to CYP6AE24 Helicoverpa armigera

CYP6AE51   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AE52   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AF1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPq3l1
            Note: CYP6AF1 and CYP6AF2 are nearly identical duplicate genes

CYP6AF2     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPq3l2
            Note: CYP6AF1 and CYP6AF2 are nearly identical duplicate genes

CYP6AF frag. Anopheles funestus
            No accession number
            Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson, 
            Lizette Koekemoer, on Sept. 9, 2004
            78% identical to both CYP6AF1 and CYP6AF2 I-helix to heme
            it is not known if A. funestus has the same gene duplication
            as A. gambiae, so this sequence cannot be named yet.

CYP6AG1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPh2r1

CYP6AG2     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPh2r3

CYP6AG3     Aedes aegypti (yellow fever mosquito)

CYP6AG4     Aedes aegypti (yellow fever mosquito)

CYP6AG5     Aedes aegypti (yellow fever mosquito)

CYP6AG6     Aedes aegypti (yellow fever mosquito)

CYP6AG7     Aedes aegypti (yellow fever mosquito)

CYP6AG8     Aedes aegypti (yellow fever mosquito)

CYP6AG9     Culex pipiens

CYP6AG10    Culex pipiens

CYP6AG11    Culex pipiens

CYP6AG12    Culex pipiens

CYP6AG13    Culex pipiens

CYP6AG14    Culex pipiens

CYP6AG15    Culex pipiens

CYP6AG16    Culex pipiens

CYP6AH1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs2l4

CYP6AH1     Aedes aegypti (yellow fever mosquito)

CYP6AH2     Culex pipiens

CYP6AH3     Culex pipiens

CYP6AJ1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs3l3

CYP6AK1     Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs3l2

CYP6AK1     Aedes aegypti (yellow fever mosquito)

CYP6AK1     Culex pipiens

CYP6AK1-de1b  Culex pipiens
              Pseudogene

CYP6AL1     Aedes aegypti (yellow fever mosquito)

CYP6AL1     Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I1.2

CYP6AL2v1   Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T1.2

CYP6AL2v2   Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I2.3

CYP6AL3     Aedes aegypti (yellow fever mosquito)

CYP6AM1     Homotermopsis sjostedti (termite)
            No accession number
            Richard Cornette
            Submitted to nomenclature committee Jan. 20, 2004

CYP6AM2     Blattella germanica (German cockroach)
            No accession number
            Ameya D. Gondhalekar and Mike Scharf
            submitted to nomenclature committee Nov. 21, 2010
            53% to CYP6AM1 in the N-terminal only

CYP6AN1     Helicoverpa armigera (cotton bollworm)
            No accession number
            Vladimir Grubor
            submitted to nomenclature committee Dec. 30, 2003
            54% to 6AB1, 6AB2, 6AB3 C-term frag. 197 aa 
            seq #2 HaCypZ005a-v2Pep

CYP6AN1     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_171 100% to CYP6AN1 from Vladimir Grubor, 
            60% to CYP6AN2 Bombyx, 
            55% to CYP6AB4, 53% to CYP6AB9
            the CYP6AN and CYP6AB subfamilies overlap

CYP6AN2     Bombyx mori (silkworm)
            no accession number
            see silkworm page for details

CYP6AN3     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_241 89% to CYP6AN1, 61% to CYP6AN2 Bombyx, 54% to CYP6AB4
            the CYP6AN and CYP6AB subfamilies overlap

CYP6AN4     Spodoptera frugiperda (a moth)
            No accession number
            Rene Feyereisen
            Submitted to nomenclature committee Nov. 21, 2008
            77% to CYP6AN1 Helicoverpa amigera
            81% to CYP6AN3 partial seq, 62% to CYP6AN2 Bombyx

CYP6AN4     Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            94% to CYP6AN4 Spodoptera frugiperda (ortholog)

CYP6AN5    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6AN6     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            85% to CYP6AN1 Helicoverpa armigera

CYP6AN7     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            87% to CYP6AN1 Helicoverpa armigera

CYP6AN8     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            85% to CYP6AN1 Helicoverpa armigera

CYP6AN9     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            56% to CYP6AN5 Manduca sexta

CYP6AN10    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            83% to CYP6AN9 Heliconius melpomene

CYP6AN11    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            56% to CYP6AN5 Manduca sexta

CYP6AN12    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            59% to CYP6AN4 Spodotera frigiperda

CYP6AN13    Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            92% to CYP6AN12 Heliconius melpomene

CYP6AN14   Plutella xylostella (L.) (diamondback moth)

CYP6AN15v1 Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AN15v2 Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AN16   Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP6AP1X    Helicoverpa armigera (cotton bollworm)
            No accession number
            Vladimir Grubor
            submitted to nomenclature committee Dec. 30, 2003
            51% to 6P5 (58/113aa), C-term frag. 144 aa seq #8
            renamed CYP337B1 54% (76/140aa) to 337A1 over a longer range
            this partial sequence clusters with CYP337A1 and A2 on trees.

CYP6AQ1     Apis mellifera (honeybee)
            WGS section genbank
            ESTs = BE844578, BE844462, BE844394, BE844353, BE844352,
            BE844331, all ESTs from antennae
            Submitted by May Berenbaum 2/11/04
            AmGroup12.14
            Am2_12.16 (1067523-1070348),
            45% to CYP6K1, 42% to Cyp6g2

CYP6AQ2     Philotrypesis sp5 (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            sequence 2
            50% to Philotrypesis sp. 6AS21, 51% to Philotrypesis sp1 6AS22, 
            49% to Philotrypesis pilosa 6AS20, 
            51% to CYP6AQ1 Apis, 49% to 6A5 housefly
            this seq missing 5aa at heme signature compared to 6AQ3
            CYP6AQ is one of 5 clear subdivisions in the CYP6 family in wasps
            These clades are deeper than typical subfamilies.

CYP6AQ3     Philotrypesis sp5 (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            sequence 3
            52% to Philotrypesis sp. 6AS21, 53% to Philotrypesis sp1 6AS22,
            51% to Philotrypesis pilosa ^AS20, 46% to CYP6CK1
            only diff with CYP6AQ2 is a 5 aa insert
            51% to CYP6AQ1 Apis, 51% to 6A5 housefly
            68% TO Nasonia Nv6-22i and 53% to Tribolium 345A1
            68% to Nasonia Nv6-23, 65% to Nv6-P2 and CYP6AQ1 Apis

CYP6AQ4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AQ5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AQ6P   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AQ7    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AQ8    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AQ9    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AQ10   Linepithema humile (argentine ant)
           No accession number

CYP6AQ11   Linepithema humile (argentine ant)
           No accession number

CYP6AQ12   Linepithema humile (argentine ant)
           No accession number

CYP6AQ13   Linepithema humile (argentine ant)
           No accession number

CYP6AQ14   Linepithema humile (argentine ant)
           No accession number

CYP6AQ15   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           69% to CYP6AQ10 Linepithema humile

CYP6AQ16   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           69% to CYP6AQ10 Linepithema humile

CYP6AQ17   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           76% to CYP6AQ14 Linepithema humile

CYP6AQ18   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           61% to CYP6AQ10 Linepithema humile

CYP6AR1X    Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.19
            Am2_5.8 (434944-432195),
            50% to CYP6AS1
            renamed CYP6AS19 as part of a larger clade
            that became obvious with inclusion of wasp P450s from Nasonia

CYP6AS1     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.5496
            Am2_Un.5363 (3492-1105),
            44% to CYP6A14, 64% to 6AS3

CYP6AS2     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.792a
            Am2_Un.476 (25830-23485)
            86% to 6AS1

CYP6AS2P1   Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.5353 (3026-2045)
            92% to last 3 exons of CYP6AS2

CYP6AS3     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.792b
            Am2_Un.476 (20769-18418)
            64% to 6AS1

CYP6AS4     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.1753
            Am2_Un.476 (1718-4379)
            80% to 6AS6

CYP6AS5     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.42a
            Am2_Un.4238 (9913-6869)
            56% to 6AS1

CYP6AS6X    Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.42b
            Am2_13.15 (124021-121751)
            80% to 6AS4
            renamed CYP6AS17 and CYP6AS18
            two very similar genes, not alleles

CYP6AS7     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.42c
            Am2_13.15 (119129-116557)
            66% to 6AS4

CYP6AS8     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.4533
            Am2_13.16 (153493-156158)
            65% to 6AS9

CYP6AS9P     Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.2792
            Am2_13.17 (7981-5161)
            65% to 6AS8, frameshift at RNHL and bad boundary at EXXR

CYP6AS10    Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.2631
            Am2_13.17 (13740-10480)
            53% to 6AS8

CYP6AS11    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_13.16 (147797-150778)
            Looked like a pseudogene in ver 1.2 now looks whole
            83% to 6AS8

CYP6AS11-de1b   Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_13.16 (152312-152647) 
            only 6 amino acid differences to 6AS11 in an 11 amino acid window
            alternative exon 1

CYP6AS12    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.476 (9611-6794)
            Looked like a pseudogene in ver 1.2 now looks whole
            64% to 6AS9

CYP6AS13    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.5370 (9442-11518),
            63% to 6AS2

CYP6AS14    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_13.16 (142794-146154),
            73% to 6AS8

CYP6AS15    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.210 (2742-6273)
            68% to 6AS8

CYP6AS16    Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.5370 (792-4695),
            64% to 6AS9

CYP6AS17    Apis mellifera (honeybee)
            Am3_13.15 (12051-14321), 
            497 aa, 5 exons, 5 aa differences between CYP6AS6v1 and CYP6ASv2 
            version 2 = CYP6AS6 Am2_13.15 (124021-121751), 497 aa, 5 exons
            version 1.2 = CYP6AS6 Am1.2_13.15c (120924-123194) minus
            version 1.1 = CYP6AS6 Am1.1_Un.42b (121844-124324) minus,
            41% to 6a17, best matches all CYP6As 80% to 6AS4
            name changed from CYP6AS6v1, two genes, not alleles
MFDYFQILIAFVASFLALYYYLTSNFDFWKNRNVVAPKPIPFFGNTKDVVLKKIEISNFIA
ELYKKYENEAMFGIFFGGSPNLILRDLDLIKDVLIKDFSTFDERGFKISER (0)
ADPLNANLFNMDVTRWRPLRIKLSPVFTSGKLKEMFPLILKCAERLEQCLEDAVKRGGPVD
CFEISARYTTDVIGSCAFGINMNALSDERSEFRRIGKRIFDLDKNILRSFLRQFFPRFYNL
LGFVIPYSETSKFVTKFISEMIKYREENNVVKADFVNLLMELKKHPEKLQNI (1)
KITDNLLAAQAFVFFAAGFETSSTTMAHALYEMALNPNIQDKLRKEIKEFYANNNFTYEEV
KKMKYLDKVFK (1)
ETLRKYPPGVFLKRKCNSNYTFKGTKVSIPAGTSVIIPVYSIQTDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRKCI (1)
GIRFGVYQTKVGLIKMLKNFKVNVCEKTMIPYIKKINSFTLAPKDGIFLKIEKNN*

CYP6AS18    Apis mellifera (honeybee)
            Am3_13.15 (6830-9094), 497 aa, 5 exons
            version 2 = CYP6AS6v2 Am2_Un.4238 (4309-2045), 497 aa, 5 exons, 
            completes on N-term what appeared to be a single exon fragment 
            in version 1.2
            version 1.2 = CYP6AS6-se1[5] Am1.2_13.15a solo exon pseudogene 
            (132407-132573) minus, 54 aa, 1 exon
            the two sequences are on AADG03005752.1 11483 bp apart
            name changed from CYP6AS6v2, two genes, not alleles
MFDYFQILIAFVASFLALYYYLTSNFDFWKNRNVVAPKPIPFFGNTKDVVLKKIEISNFIA
ELYKKYENEAMFGIFFGGSPNLILRDLDLIKDVLIKDFSTFDERGFKISER (0)
ADPLNANLFNLDVTRWRSLRIKLSPVFTSGKLKEIFPLILKCAERLEQCLEDAVKRGGSVD
CFEISARYTTDVIGSCAFGINMNALSDERSEFRRIGKRIFDLDKNILRSFLRQFFPRFYNL
LGFVIPYSETSKFVTKFISEMIKYREENNVVKADFVNLLMELKKHPEKLQNI (1)
KITDNLLAAQAFVFFAAGFETSSTTMAHALYEMALNPNIQDKLRKEIKEFYANNNFTYEEV
KKMKYLDKVFK (1)
ETLRKYPPGVFLKRKCNSNYTFKGTKVSIPAGTSVIIPVYSIQTDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRKCI (1)
GIRFGVYQTKVGLIKMLKNFKVNVCEKTMIPYIKKINSFTLAPKDGIFLKVEKNN*

CYP6AS19    Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroupUn.19
            Am2_5.8 (434944-432195),
            50% to CYP6AS1
            formerly CYP6AR1
            renamed CYP6AS19 as part of a larger clade
            that became obvious with inclusion of wasp P450s from Nasonia

CYP6AS20    Philotrypesis pilosa (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            95% to Philotrypesis sp. 6AS21, 91% to Philotryp. sp4 sequence 1 6AS23
            90% to Philotrypesis sp1 6AS22, 61% to CYP6AS4 Apis
            probable ortholog of CYP6A21
            78% to Nv6-8, 68% to Nv6-7i, 60% to Nv6-9, 63% to Nv6-27
            note: on Feb. 18, 2008 Ying Liu sent a possible extension
            of this gene into the middle region of the gene.

CYP6AS21    Philotrypesis sp. (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            95% to Philotrypesis pilosa 6AS20, 91% to Philotrypesis sp1 6AS22,
            90% to Philotrypesis sp4 sequence 1 6AS23, 63% to CYP6AS4 Apis
            probable ortholog of CYP6A20
            80% to Nv6-8, 68% to Nv6-7i, 63% to Nv6-9, 63% to Nv6-27
            note: on Feb. 18, 2008 Ying Liu sent a possible extension
            of this gene into the middle region of the gene.

CYP6AS22    Philotrypesis sp1 (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            92% to Philotrypesis sp4 sequence 1 6AS23, 90% to Philot. pilosa 6AS20
            91% to Philotrypesis sp. 6AS21, 64% to CYP6AS4 Apis
            80% to Nv6-8, 68% to Nv6-7i, 64% to Nv6-9, 64% to Nv6-27

CYP6AS23    Philotrypesis sp4     sequence 1 (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            91% to Philotrypesis pilosa 6AS20, 92% to Philotrypesis sp1 6AS22,
            90% to Philotrypesis sp. 6AS21, 64% to CYP6AS4 Apis
            78% to Nv6-8, 68% to Nv6-7i, 65% to Nv6-9, 61% to Nv6-27

CYP6AS24    Philotrypesis sp4     sequence 2 (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            65% to Philotrypesis sp5 sequence 1 6AS25, 57% to CYP6AS4 Apis
            57% to Philotrypesis sp1 6AS21
            55% to fire ant EST EE143495.1 Lausanne fire ant
            66% to Nv6-5, 63% to Nv6-6

CYP6AS25    Philotrypesis sp5    sequence 1 (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 28, 2007
            65% to Philotrypesis sp4 sequence 2 6AS24, 52% to Philot. sp1 6AS22,
            51% to Philotrypesis sp4 sequence 1 6AS23, 51% to Philot. pilosa 6AS20
            52% to Philotrypesis sp. 6AS21, 50% to CYP6AS4 Apis
            58% to Nv6-6, 56% to Nv6-5

CYP6AS26    Solenopsis invicta (Lausanne fire ant) 
            EST EE143495.1 
            63% to Nv6-28, 62% to 6AS2 Apis

CYP6AS27   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS28P  Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS29   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS30   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS31   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS32   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS33   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS34   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS35   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS36P  Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS37P  Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6AS38    Apocrypta bakeri (fig wasp)
            No accession number
            Liu Ying
            Submitted to nomenclature committee Feb. 18, 2008
            Probable ortholog of CYP6AS20 (71% identical)

CYP6AS39   Linepithema humile (argentine ant)
           No accession number

CYP6AS40   Linepithema humile (argentine ant)
           No accession number

CYP6AS41P  Linepithema humile (argentine ant)
           No accession number

CYP6AS42   Linepithema humile (argentine ant)
           No accession number

CYP6AS43   Linepithema humile (argentine ant)
           No accession number

CYP6AS44   Linepithema humile (argentine ant)
           No accession number

CYP6AS45P  Linepithema humile (argentine ant)
           No accession number

CYP6AS46   Linepithema humile (argentine ant)
           No accession number

CYP6AS47   Linepithema humile (argentine ant)
           No accession number

CYP6AS48   Linepithema humile (argentine ant)
           No accession number

CYP6AS49   Linepithema humile (argentine ant)
           No accession number

CYP6AS50P  Linepithema humile (argentine ant)
           No accession number

CYP6AS51   Linepithema humile (argentine ant)
           No accession number

CYP6AS52   Linepithema humile (argentine ant)
           No accession number

CYP6AS52-de5b  Linepithema humile (argentine ant)
           No accession number

CYP6AS53   Linepithema humile (argentine ant)
           No accession number

CYP6AS54   Linepithema humile (argentine ant)
           No accession number

CYP6AS55   Linepithema humile (argentine ant)
           No accession number

CYP6AS56   Linepithema humile (argentine ant)
           No accession number

CYP6AS57   Linepithema humile (argentine ant)
           No accession number

CYP6AS58   Linepithema humile (argentine ant)
           No accession number

CYP6AS58v2  Linepithema humile (argentine ant)
           No accession number

CYP6AS59   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           71% to CYP6AS55 Linepithema humile

CYP6AS60   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           62% to CYP6AS52 Linepithema humile

CYP6AS61   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP6AS55 Linepithema humile

CYP6AS62   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP6AS52 Linepithema humile

CYP6AS63   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           73% to CYP6AS52 Linepithema humile

CYP6AS64   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           76% to CYP6AS52 Linepithema humile

CYP6AS65   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           71% to CYP6AS42 Linepithema humile

CYP6AT1    Phyllopertha diversa (scarab beetle)
           No accession number
           Walter Leal
           Submitted to nomenclature committee Nov. 4, 2003
           Clone name Cyp6Pd
           43% to CYP6K1 

CYP6AU1    Bombyx mori (silkworm)
           BAAB01129923.1
           40% TO 6B1
           See silkworm page for sequence

CYP6AV1    Bombyx mori (silkworm)
           BAAB01020563.1  BAAB01140967.1
           44% TO 6AB1
           See silkworm page for sequence

CYP6AW1    Bombyx mori (silkworm)
           BAAB01195862.1 BAAB01153386.1 CK496233 EST
           39% to CYP6P5
           See silkworm page for sequence

CYP6AW1     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            68% to CYP6AW1 Bombyx mori
            formerly CYP6AW2

CYP6AW1     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            74% to CYP6AW1 Bombyx mori
            formerly CYP6AW3

CYP6AW1     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            98% to CYP6AW3 Heliothis subflexa
            formerly CYP6AW3

CYP6AX1    Nilaparvata lugens biotype II (brown planthopper)
           GenEMBL AJ852422, AJ629021 partial EST
           Zhifan Yang and Guangcun He
           Submitted to nomenclature committee Sept. 21, 2004
           39% to CYP6A20 Drosophila pseudoobscura
           full length sequence known but confidential
           falls inside the CYP6 family on trees with all CYP6 subfams
           clone sequence 1
           
CYP6AX2    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 85% to 6AX1 Nilaparvata lugens

CYP6AY1    Nilaparvata lugens biotype II (brown planthopper)
           GenEMBL AJ852423
           Zhifan Yang and Guangcun He
           Submitted to nomenclature committee Sept. 21, 2004
           41% to CYP6M1, 40% to Cyp6a2
           full length sequence known but confidential
           falls inside the CYP6 family on trees with all CYP6 subfams
           clone sequence 2

CYP6AY2    Sogatella frucifera (white-backed plant hopper)
           No accession number
           Shi Xiaoqin
           Submitted to nomenclature committee March 25, 2011
           Clone name sf27 and sf28 two pieces probably from the same gene
           88% to CYP6AY1 Nilaparvata lugens

CYP6AY3    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 83% to 6AY1 Nilaparvata lugens

CYP6AZ1    Mayetiola destructor (Hessian fly)
           No accession number 
           Omprakash Mittapalli Richard Shukle
           Submitted to nomenclature committee Nov. 22, 2004
           43% to CYP6F1 from Culex mosquito, only 36% to 6BA1
           clone name HFP450-1

CYP6BA1    Mayetiola destructor (Hessian fly)
           No accession number 
           Omprakash Mittapalli Richard Shukle
           Submitted to nomenclature committee Nov. 22, 2004
           45% to CYP6Z3 from Anopheles, only 36% to 6AZ1
           clone name HFP450-2

CYP6BB1v1  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY896792
           Shaoming Huang
           Submitted to nomenclature committee Jan. 7, 2005
           Very close to CYP6P subfamily.
           One CYP6P is above 55% identical but the rest are below 55%
           Clone name G2-5-2
           99.2% to CYP6BB1v2

CYP6BB1v2  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY896793
           Shaoming Huang
           Submitted to nomenclature committee Jan. 7, 2005
           Very close to CYP6P subfamily.
           One CYP6P is above 55% identical but the rest are below 55%
           Clone name G2-5-3
           98.8% to CYP6BB1v3

CYP6BB1v3  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY896794
           Shaoming Huang
           Submitted to nomenclature committee Jan. 7, 2005
           Very close to CYP6P subfamily.
           One CYP6P is above 55% identical but the rest are below 55%
           Clone name G2-5-4
           98.4% to CYP6BB1v4

CYP6BB1v4  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY896795
           Shaoming Huang
           Submitted to nomenclature committee Jan. 7, 2005
           Very close to CYP6P subfamily.
           One CYP6P is above 55% identical but the rest are below 55%
           Clone name S7
           98.2% to CYP6BB1v5

CYP6BB1v5  Ochlerotatus sollicitans (salt marsh mosquito)
           GenEMBL AY896796
           Shaoming Huang
           Submitted to nomenclature committee Jan. 7, 2005
           Very close to CYP6P subfamily.
           One CYP6P is above 55% identical but the rest are below 55%
           Clone name S9
           98.2% to CYP6BB1v4

CYP6BB1v6   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ059299.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone6BB1
            Identical aa seq to 6BB1v3 and 6BB1v4, but nucleotide seq is different
            partial seq, 420 aa

CYP6BB1v7   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427072.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 1-1
            65% to CYP6P3, 1aa diff to CYP6BB1v5
            partial seq, 84 aa EXXR to heme

CYP6BB1v8   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427076.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 13
            65% to CYP6P3, 2aa diff to CYP6BB1v7
            partial seq, 84 aa EXXR to heme

CYP6BB1v9   Ochlerotatus sollicitans (salt marsh mosquito)
            GenEMBL DQ427083.1
            Shaoming Huang
            Submitted to nomenclature committee Feb. 5, 2006
            Clone 25
            65% to CYP6P3, 1aa diff to CYP6BB1v7
            partial seq, 84 aa EXXR to heme

CYP6BB2     Aedes aegypti (yellow fever mosquito)

CYP6BB3    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/19/07
           sequence 7
           66% to CYP6BB1 salt marsh mosquito Ochlerotatus sollicitans

CYP6BB3     Culex pipiens

CYP6BB4     Culex pipiens

CYP6BC1     Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_1.19 (858065-862228)
            46% to 6AS7

CYP6BC2    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6BC3    Linepithema humile (argentine ant)
           No accession number

CYP6BC4    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           81% to CYP6BC3 Linepithema humile

CYP6BD1     Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_11.13 (431584-428990)
            41% to 6AQ1

CYP6BD2    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6BD2-de4b    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6BD3    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6BD4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6BD5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6BD6    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6BD7    Linepithema humile (argentine ant)
           No accession number

CYP6BD8    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           73% to CYP6BD7 Linepithema humile

CYP6BD9    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP6BD5 Nasonia vitripennis

CYP6BD10   Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 55% to CYP6DB2 whitefly Trialeurodes vaporariorum
           92% to CYP6DB5 Sogatella furcifera

CYP6BD11   Plutella xylostella 
           Gene number CCG003086.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           66% to CYP6BD5 Nasonia vitripennis

CYP6BE1     Apis mellifera (honeybee)
            Version 2 Baylor College of Medicine
            Submitted by Reed Johnson 2/9/05
            Am2_Un.1086 (577-5116)
            42% to 6AS2

CYP6BE2    Linepithema humile (argentine ant)
           No accession number

CYP6BE2-de2b  Linepithema humile (argentine ant)
           No accession number

CYP6BE3    Linepithema humile (argentine ant)
           No accession number

CYP6BE4P   Linepithema humile (argentine ant)
           No accession number

CYP6BE5P   Linepithema humile (argentine ant)
           No accession number

CYP6BE6    Linepithema humile (argentine ant)
           No accession number

CYP6BE7    Linepithema humile (argentine ant)
           No accession number

CYP6BE7-de6b  Linepithema humile (argentine ant)
           No accession number

CYP6BE8    Linepithema humile (argentine ant)
           No accession number

CYP6BE9P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           66% to CYP6BE6 Linepithema humile

CYP6BE10P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           62% to CYP6BE1 Apis mellifera

CYP6BE11P  Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           75% to CYP6BE6 Linepithema humile

CYP6BF1v1   Plutella xylostella (L.) (diamondback moth)
            GenEMBL AY971374
            Hongshan Li
            Submitted to nomenclature committee June 8, 2005
            Clone name msword
            3 nuc diffs and 1 aa diff to CYP6BF1v2

CYP6BF1v2   Plutella xylostella (L.) (diamondback moth)
            No accession number
            Hongshan Li
            Submitted to nomenclature committee June 8, 2005
            Clone name A3b3
            3 nuc diffs and 1 aa diff to CYP6BF1v1

CYP6BF1v3   Plutella xylostella (L.) (diamondback moth)
            No accession number
            Hongshan Li
            Submitted to nomenclature committee June 8, 2005
            Clone name A1
            96% at the nucleotide level and 1 aa diff to CYP6BF1v1

CYP6BF1v4   Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee Nov. 17, 2005
            Clone name Sequence 1. 6XYr21 (Full cDNA sequence)
            98% identical to 6BF1v1, 6BFv2 and 6BFv3

CYP6BF1    Plutella xylostella 
           Gene number CCG013145.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           complete

CYP6BG1     Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee June 12, 2005
            Clone name sequence 1
            62% to CYP6AE1 but only I-helix to heme fragment
            69% to CYP6BG2

CYP6BG2     Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee June 12, 2005
            Clone name sequence 2
            55% to CYP6AE1 but only I-helix to heme fragment
            69% to CYP6BG2

CYP6BG3    Plutella xylostella 
           Gene number CCG014217.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           incomplete

CYP6BG4    Plutella xylostella 
           Gene number CCG005902.4
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Complete, 96% to CYP6BG5

CYP6BG5    Plutella xylostella 
           Gene number CCG014216.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           complete

CYP6BH1v1   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee June 29, 2005
            39% to 6N3

CYP6BH1v1   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P6BH203 r1e10
            64 amino acids from heme to end
            100% to CYP6BH1v1

CYP6BH1v2   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee June 29, 2005
            39% to 6N3, 100% to CYP6BH1v1 at amino acid level
            4 nucleotide differences

CYP6BH1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Shi Xiaoqin 
           Submitted to nomenclature committee Dec. 10, 2010 
           CYP3 clan
           Clone name seqs. 10 and 26
           100% to CYP6BH1 Leptinotarsa decemlineata
           two partial sequences
           
CYP6BH2    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-13
           87% to CYP6BH1v2 Leptinotarsa decemlineata
           53% to CYP6ED1 (P-6-1), C-helix region

CYP6BJ1v1   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee June 29, 2005
            46% to 6M1

CYP6BJ1v1   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P6BJ7946
            64 amino acids from heme to end
            100% to CYP6BJ1v1

CYP6BJ1v2   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P6BJ146c61
            61 amino acids from heme to end
            98% to CYP6BJ1v1, 1 aa diff

CYP6BJ2     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P6BJ42c63
            64 amino acids from heme to end
            92% to CYP6BJ1v1, 5 aa diff

CYP6BJ3    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-9
           87% to CYP6BJ1v1 Leptinotarsa decemlineata (aa 166-251)

CYP6BK1     Tribolium castaneum 
            GenEMBL XP_970556
            67% to CYP6BK2
MFSVLVFLIIVVVFLYYKWAFTYWHRRNIPYLEPSFPFGNLPNLFQRKENIGLTVEKFYNEMKRRKWKHG
GVYFLVSPVYCVIDLEYVKNIMNRDFEYFTNRSIYYNEKDDPLSAHLFAIGGQKWRNLRTKLTATFTSGK
MKAMFQTLLECETNLLKQIEDCNNPINIKEILSCFTTDVIGSVGFGLECKTFEEKNSPFRIYGKKVFKDS
VLRSLKRAFLTSNFPELARKLGILAFPSEITDFFLKVVADTVKYREENNRSRNDFLQLLIDLKNSGTLSL
EEIAAQCFLFFLAGFETSSTTMTFALYELAQHQDIQDKVREEIDAVLKKYGGKITYEAIHDMKYMNQVID
ETLRKYPAASIITRTCVKDYKIPDQDIVIEKGTSVIIPVLGIHHDEKFYPNPEKFDPERFTEENKAARHH
YAHLPFGEGPRICIGMRFGLVQSKVGLTSLLKNYIFKVNKKTIEPLKMQARSLILAAEGEIWLDVYKL

CYP6BK2     Tribolium castaneum 
            GenEMBL XP_970481
            65% to 6BK4, 67% to 6BK1
MLFSDSLTKDLFGCVLTFAILIIAYFKWSYQYWKRKNLPYLKPTFPFGNITGLLTRKETFGVIIQKVYQE
MKNCNWNHGGIYLTLNPAYCAIDLEYVKNIMTKDFQHFVDRGSYYNEKDDPLSAHLFAIGGQKWRNLRTK
LTPTFTSGKMKQMFQTLVDCESNLAKKIDMEYEKKHPIDIKEVLGCFTTDIIGSCAFGLDCKTFEHENSP
FRVYGKKLFKGSTLRNIKRSLLTQNFPDLAQKLGVLALPEDISNFFMKVVKDTVRYREKNGFTRSDFLQL
LINLKNSKVAEEEGYKHDGNTLTLEEIAAQSFVFFIAGFETSSTTMTFALYELAKNQEIQSQVREEIDAV
LKKHDGKITYDSIQDMKFMNQVIDETLRKYPPIPFVTRKCVNNYQIPGENIVIEKGTTVIIPILGIHYDK
DYYPNPEKFDPERFTEKNKNARHHYAHIPFGEGPRICIGARFGLMQTKVGLISLLRNYKFTVNNMTREPL
RMQVDSFVLAAEGEIWLDAHKL

CYP6BK3     Tribolium castaneum 
            GenEMBL XP_966437 or XP_975753
            changed C-term seq on XP_975753
            this end is a better match to 
            CYP6BK4 and is probably the correct C-term
MFVSNSLLGDLIALFVTLGVLLTFYFKWTYQYWTRRNVPQIDPHIPFGNISESIKGREIVGVTFKKIYQQ
LKSQGCRHGGIYIFTQPSYFPIDLDYIRNILTKDFQYFVDRPFYVNEKDPLQAHLLNLSGTRWRNMRSKL
TPTFTSGKMKLMFHIMAESQSDLLKRMDKEAESLEPINIKEVLACFTTNIIGSCAFGLDCKALEDENSPF
RQFGKKLFKISVLHRLKRTFAATFPDFAKFLRMSNSRKEIVKFIMDMVEGTIEYREKNNYSRNDFMQLLI
DMKNNKPKGDHDGKPLTLDEVASQAIVFFAAGFETSSTLMTFAFYELAKNPHIQDKLREEINLILAEHNN
EISYDAIQEMKYLSQVIDETLRLHPPAAQTSRKCIKDYKIPDQDITIEKGTSVTVSILGIHHDPDYYPDP
EKFDPERFTEENKSLRHNYAFLPFGEGPRNCIGMRFGLLQSKMGLVSLIKNYKFTVNEKTK
EPITYQPAHVVLAAQGEIWLNAQKV

CYP6BK4     Tribolium castaneum 
            GenEMBL XP_970415
            65% to 6BK2
MLITTSLTGDLLAVFLTLVLIIVTYCKWSYQYWERKHLPYLEPQIPFGNVGDSIKGKTNFGITIKKIYEE
MKHNGWKHGGLYVFTEPNYMVLDLEYVKNIMTKDFQYFVDRSTYYNKKEDPLNAHLLNLGGTKWRNLRTK
LTPTFTSGKMKMMFQTLADCQTGLLKRMEKERLTRQPIDIKEVLACFTTEIIGSCAFGLNCKAFEDENSP
FRVYGRKVFATSKLQRLKRTIATIFPTLGYLFNISITPKDITNFYLNVVKDTVEYREKNNYNRNDFMQLL
IDLKNNKLEGGTSNGGFTLKEVAAQSFVFFLAGFETSSTLMTFALYELARHQEIQDIVREEINEVLRKHN
GNVTYDSINDMKYLSQVIDETLRLYPPASLVNRKCIKDYQVPDCDLVIEKGTTVLIPIMGIHYDKDYYPD
PEKFDPERFTEENKNARHNYAHIPFGEGPRICIGMRFGLMQTKVGLSCLLKHYKFTVNKRTQEPLKMQPS
PLILSAEGEIWLDAEKL

CYP6BK5     Tribolium castaneum 
            GenEMBL XP_970347, AAJJ01005400.1 has exact match, runs off the end
            73% to 6BK2
   1 IGDFFLKVVKDTVNYREKNNFTRKDFMQLLIDLK
 105 NNKLVGEEGKSERGLTIEEVAAQSFVFFLAGFETSSTTMTFALYEMAKHQDIQAKVREEIDT
     VLKKHDGKITYEAIQEMKYMGQVID (1) 365
2242 ETLRKYPPVPFLTRQCVKDYKIPNEDVTIEKGTTVIIPVLGIHYD
     KDIYPDPEKFDPERFTEENKNARHNYSHIPFGEGPRICIGMRFGLMQSKVGLTSLLKKYKFTVNKKTQEP
     IKFQVNPFILAAEGEIWLSAEKI* 2658

CYP6BK6     Tribolium castaneum 
            GenEMBL XP_970282
            76% to 6BK12
MFRFLDLVGVFIALFAILFAYFKWTYQYWSQKNVPFIQPTIPFGNSNLFRQKESGGIRMKNFYDEMKAQG
WKHGGLYSILKPSYMVIDLDYLKNIMTKDFDYFSDRGFYYNEKDDPLSAHLFAIGGEKWRNLRIKLTPTF
TSGKMKMMFQTLVDCAPGLVKQIDRKMESIDIKEVLGCFTTDIIGSCAFGLDFNTSNDNNSPFREYGRKA
FVPTKFDIVKIIFAMSFPRLAQLFRLTLTRKDVSEFFLKVVRETVEYREKNNYRRKDFIQLLIDLKGEDG
KTLTINEIAAQSFVFFIAGFETSSTTMAFVLYELSRRPDLQQKLRDEINTVLSRYEGSITYEATQEMKYM
DQVINEALRMYPPVPMLGRKCVKDYKIPDQDVIIEKGTSILIPVLGIHYDQEYYPDPKTFDPERFNEENR
KARHHYAHLPFGEGPRICIGMRFGLMQTKVGLATLLKNYKFKVGERTQEPLKFKVASFVLAAEGEIWLDAEKL

CYP6BK7     Tribolium castaneum 
            GenEMBL XP_970215
            67% to 6BK6
MFTFVGVAIALLATLFAYFKWTYKYWERRNLQYLEPKIPYGNGTGPFKRTENAGFRFKRQYEELKSRGWK
HGGLYSILNPIYLVADLDYIKNIMTKDFHYFTDRGIYYNEKNDPLSAHLFALGGPKWRHLRTKLSPTFTS
GKMKQMFQTLVDCVPQLLQQIDKNVPVDIKEVLGCFTTDIIGSCAFGLECKTFEDENSPFREYGRKFFQV
SNLKIAKFLFSGNFPNVARTLGVTITSKDVSDFFISVVEDTVKYREKHNLVRKDFMQLLIDLKNTEKEQM
LTIEELAAQCFVFFIAGFETSSTTMTFALFELAKRPDLQQQVRDEIETVLAKHGNITYDAIQDLKFMDQV
IDETLRMYPPVPVLTRKCVKDYKIPDQDVIIQKGTRVFIPVLGIHYDSDLYPNPSQFDPDRFSEEKKKSR
HGYAHLPFGEGPRICIGMRFGLMQTKVGLTALLKNYKFSVNSKTQTPLKMKPNSFILAAEGDVWLNAQKV

CYP6BK8P    Tribolium castaneum 
            GenEMBL AAJJ01004329 Pseudogene
            61% to 6BK11
3214 MFFDSISLNVLSVFIALTAVIFAYYKWTYHYWERQKLPFLTPTIPYGNILSPLSKTENFA 3035
3034 ITCKHLYNKIKQREWKHGGIYAILAPIYFVVNLDYVKNIMTKDFQYLDRGFYHKEKVDP 2858
2857 VSAHFFXXXXXX 2840
2823 QNKLTPTFTSGKMKMMFKTIADCEVNL*EKMLEEHE*KEPIDIKDILSCFTTDIIGSCAF 2644
2643 GLNCNSFKEENSAFRIYGRKVFTPTKTRVLRDTFSFNFPDLARRLNVRAFPKHIGDFFV 2467
2466 NMVKDTVNYREKNNFIRKDFMQLLIDLKNNKL 2371
2365 EEGKSERGLTIEEVAAQSFVFFLAGFETFSTTMTFALYELAKHQDIQDKVREEIDAVL 2192
2191 KKHDGK 2174
2172 AIQEMKYMGQVID (1)
     EILRKYPPIPFLTRQCVKDYRIPEE 2012
2011 DVIIEKGTTVLIPVLAIHHDKDIYPNPEKFDPERFTEERKNARHNYAHIPFGEGPKICIG 1832
1831 TRFGLMQSKVGLTSLLKKYKFTVDN*TQEPIKFQVDSFILAAEGQVWLNAERV 1673

CYP6BK9     Tribolium castaneum 
            GenEMBL AAJJ01000871.1, one stop codon, possible pseudogene
            65% to 6BK4, 67% to 6BK1
            note this seq has P450s from 3760-6622, 22800-21300 (-) = CYP6BR1,
            29500-31000 = CYP6BR2, 33000-38500 = CYP6BR3
            46% to 6BE1 bee, similar to 6A and 6N subfamilies
3760  MMCILGVF
3784  IALLAVILTSYYKWSFQYWERKNLPYLKPTIPYGNITSPFNRKENIAVTIQNIYEEMKTR  3963
3964  GWRHGGIYTVTSPAYFLVNLDYVKNIMTKDFQHFVNRGFYHNENDDPVSAHLFAIGGSKW  4143
4144  RFLRTKLTPTFTSGKMKMMF*TLADCEINLQEKMQDEFEKNQPIDIKEILACFTTDIIDS  4323
4324  CVFGLDCNSFKEENLPFRQYGRKVFAATKFRVVRSTFAANFPDLARFLKVRTFPKDIGD  4500
4501  FFLKVVKDTVNYREKNNFTRKDFMQLLIDLKNNKLVGEEGKSERGLTIEEVAAQSFV  4671
4672  FFLAGFETSSTTMTFALYEMVKHQHIQAKVREEINTVLQKHDGKITYEAIQEMKYMGKVVD (1) 4854
6206  ETLRKYPPVPFLTRQCVKDYKISDEDVIIEKGTTVIIPVLGIHYDKDIYPDPEKFDPERF  6385
6386  TEENKNDRHNYAHVPFGEGPRICIGMRFGLMQSKVGLTSLLKKYIFTVNKKSKEPIKFQV  6565
6566  NSLILAAQGEIWLNAERI*  6622

CYP6BK10    Tribolium castaneum 
            GenEMBL XP_969948
            55% to 6BK13
MSLLLSFLLRLGSVIISLIVVVLSVIKWKHQYWANRNIPFFPPSVPFGNLQNPRRKKHSIGYHIKNFYDQ
AKRKGWKHCGLYFFASPVYLVIDVNYVKHIMNTDFHHFVDRGMYSNEKIDPISAHLFALGGTRWKNLRNK
LSPTFTSSKMKMMFPTIVECVSLLLDAMTEKSEQIDIKELLGRFTTDIIGSCAFGLDCNTIKEENSPFRL
YGKKVFFSTKMRTFKLTFASSFPTLGRLLRIRQVSSDVSDFFRKIVKDTIEYRAQNQFSRPDFLQMLIDL
RRDGAEITLDEIIAQCFIFFLAGFETSSTTMTFTLYELAKNHQIQDKLRQEIMTILTKYHGEITYDAISE
MKYLDQVIEESLRKYPPLPFVTRTCVMDYKVPNTDLVIEKGRRVILPILALHHDPEFWPEPQNFDPERFN
DQNRNLRHQFSYIPFGEGPRFCIGKKFGLTQTKVGLVALIQNYKFSVNSRTLDPLKMAPNTFILSAAGGI
WLDSEKL

CYP6BK11    Tribolium castaneum 
            GenEMBL XP_968370
            63% to 6BK4
MLLTNSICGDLVTIFLTLVTVLTLYFKWCHQYWEKLNLPSLPPSIPFGTSLGPKGHFGLRMKHIYDKMRQ
KGWKHGGIYLMQRPFYVVVDLDYVKNIMTKDFHHFSDRGIFHNEKADPLSAHLFNISGPKWRNLRSKLTP
TFTSGKMKLMFQTLLDCEVNLRKQVEQHYEAKKPIDIKEVLGCFTTDIIGSCAFGLDCNSFKEENSPFRV
YGRRVFDRSGFIRTLKRTFASNFPNLAKLVNIALVPRDISDFFINIVKDTVEYREKNKIVRNDFLQLLLD
LKTEESGNDGTALTFEEIAAQSFVFFIAGFETSSTTMAFALYELARHQDIQDQVRDEIESVLKKYDGKIT
YEAIQEMSFLGQVIDEALRMYPPGPLVPRRCVKDYKVPNTDVVIEKGVMVLIPILGIHYDEKYYPDPEKF
DPERFSEENKALRHSYAHIPFGEGPRICIGLRFGLMQSKVGLVSLLRNFKFTVNEKTQEPLKMKTNSLVL
AVEGEIWLNVHRL

CYP6BK12    Tribolium castaneum 
            GenEMBL XP_969107
            94% to 6BK12
MPTLFDILGVSVALLVITYAYFKWRFQYWRQKNVPFLPPTVPFGNFNMLRQRDNGGILLKKFYDEMKSHG
WKHGGFYSLFQPGYLVIDLDYLKNIMTKDFDHFTDRGFYYNEKDDPLSAHLFALGGEKWRNLR TKITPTF
TSGKMKQ MFQILVDCTPDLIERIDSFCREKKPIDIKELLGCFTTDIIGSCAFGLQFNTSKDKNSPFREYG
RKAFTPTYFDIVKMTFAMAFPRLALALKLRMTRKDVSDFFLQLVRDTVKYRVENNYSRKDFIQLLIDLKS
LTIEEIAAQCFVFFIAGFETSSTTMTFVLYELSRRHDLQQKLRNEINTVLAKYDGHMTYEAIQDMKYMDQ
VINEALRMYPPVPLLSRKCVKDYKIPDQEIIIDKGTTVCIPIWGIHYDKDYYPEPEIFDPERFNEDNKKS
RHHYAHLPFGEGPRICIGLRFGLMQ TKVGLATLLQNYNFRVAGRTQEPLKYKVASFVLAAEGEIWLDAEKL

CYP6BK13    Tribolium castaneum 
            GenEMBL XP_969633
            65% to 6BK14
MFSCFLTNIIGIFVAFFAVIIAFYKWSFGYWKQKNVPYLPPKIPFGNLANPLRPAENMGVQVQHFYAQMR
AKKWKHGGLFFLANPTYMVVDLEYVKNILTKDFQHFVDRGVYYNEDVDPIGAHLFALGGTKWRNLRTKLT
PTFTSGKMKMMFQTLIDCESNLHKKIQAQKNKPIDIKDVLGCFTTDIIGSCAFGLDCNTFEDEDSPFRKY
GKKVFVATPLERLKIAIFMNFPKVGRFFKMRQVSKDISDFYSKVVKDTVEYREKHNYSRKDFMQLLIDLK
NDGNALTLDEITAQSFIFFLAGFETSSTTMTFALYELAKNSEVQEKVREEVLAVLGKHGGKITYEAIQDM
KYMNQVLNETLRKYPPVPFITRQCIKEYKIPDQEIIIETGTRVIIPILGIHYDPEYYPDPQKFDPERFSE
ENVNKRHHYAHLPFGEGPRICIGLRFGLMQSKVGLASLLSKYRFKLNERTKQPMKFQVKSFVLAAEGEVW
LDAESL

CYP6BK14    Tribolium castaneum 
            GenEMBL XP_969713
            65% to 6BK13
MEMLFSAIILILALNYFYYKWKFTYWQCKKIPTLAPKIPFGDLPNPLKQAEATGVHIKRLYDQIKGKGWK
HAGLYFLARPVYMVVDLEYVKNILTKDFHHFVDRGFYFNEKDDPISAHVFAVGGQKWRNLRTKLTPTFTS
GKMKMMFQTLLECEANLLKRFEKEHKSAIDIKDILGCFTTDIIGSCGFGLDFNTFEDENSPFRKYGKKVF
ASNLTRRLQIFFFTHFPSMARALKVRHFSKDVADFFTKVVKDTVEFRERNNYKRKDFMQLLIDLKNCNSG
LTLNEITAQSLIFFLAGFETSSTTMTFALYELAKNEKIQERVRDEIFSILGEEKITYEALQKMKYLALVI
NETLRKYPPLSFLTRECVQDYKIPDQDVIIEKGTKVVISILGMHRDQEFYPDPETFDPGRFSEGNVVSRH
QYAYIPFGEGPRICMGLRFGMMQTKVGLVSLLRKFKFTVNGRTKEPIKFDVRGFILAAEGDIWLNAQKVC

CYP6BK15P   Tribolium castaneum 
            GenEMBL XP_969180 AAJJ01005841.1
            76% to 6BK6
            N-term 133 aa not found, 
            this is probably a pseudogene, since the most 
            similar seq does not have an intron here.
1415 TEVTPSFTLGKIKQ
MFKILVDCTPDLIERIDSFCREKKPIDIKEVLGCFTTDIIGSCAIGLQFNTSKDKNSLFREYGRKAFTPT
YFDLIKMSFAMAFPRLALAFKLRMTRKDVSDFFLQLVRDTVKYRVENNYSRKDFIQLLIDLQNLTNEEIA
AQCFVFFIAGFETSSTTMTFVLYELSRRQDLQQKLRNEINTVLAKYDGHMTYEAIQDMKYMDQVINEALR
MYPPVPLLSRKCVKDYKIPDQEIIIDKGTTVCIPIWGIHYDKDYYPEPEIFDPERFNEDNKKSRHHYAHL
PFGEGPRICI (1) 504
GLRFGLMQTKVGLATLLQNYNFWVAGRTQEPLKYKVASFILAAEGEIWLDAEKL* 294

CYP6BK16P   Tribolium castaneum 
            GenEMBL XP_969554 AAJJ01002474.1
            65% to 6BK13
            three P450s on this contig 6BK13 11kb region,
            6BK14 7kb region and this one in the 15kb region
            short missing EXXR to end, pseudogene, this seq is not present before
            the end of 6BK13 is found
MGMFFTQSLLTDVTTLVVTLTVILVTYYKWSYTYWRRRGVPSLTPKIPWGNLSNPLNRKDTIGVDVKKMY
DSMRRQNWKHGGVFFMASPVYLVTDLEYVKDILTKNFQNFVDRGLYYNEKDDPISAHLFAIGGPKWRNLR
TKLTPTFTSGKMKAMFQTLLDCESNLQEKVAAELGKNQAIDIKDVFGCFTTDVIGSCAFGLDCNTFKEAD
SPFRKYGKKVFTNTPIRQLKSSFSNSFPKLAQQFGISVMPKDVSDFFTKVVKDTVEYRQKNNYTRKDFMQ
LLIDLKGEGKQDGKSLTMDEITAQSFLFFAAGFETSSTTVTFALYELAKHQDIQQKVREEIETVLAKFDG
KVTYEAIQEMHYMNQVLNVTIIK 14679

CYP6BK17    Tribolium castaneum
            No accession number
            Jiang Hongbo
            Submitted to nomenclature committee on Nov. 16, 2007
            78% to 6BK10 (not found in genome assembly)

CYP6BK18    Dastarcus helophorides (parasitoid beetle)
            KC683905
            Haidong Wang
            Submitted to nomenclature committee on Dec. 13, 2012
            58% to CYP6BK2 Tribolium

CYP6BL1     Tribolium castaneum 
            GenEMBL XP_968293
            49% to CYP6BK11
MLTSCLATLFITLLSIFAYFYKRFYFSYWERKKIPNLQQHVPRTKPHLGIQLQQLYKIMKEKKWKHGGFY
QQLSPVYVICDLNYVKNIMTRDFNYFPYRGLYYNETSDPLSAHIFNTSGAKWKRMRRKLDQIFTSSKLKT
IFPLLPNCGEKLAGKCEPVDIKKVLDDFISDVIELCVFGSECKVFKQLGRKILNRSRLRRLKGIIINNFP
KLAKILDIVLIPRDASTFFKKVVAEIVEERKKGQTGRNDFLQVLVEMEKKFEITIDEIAAQCFIFLIAGM
STSPTAMTFALYELARHQDIQEKVRQDIAKFGKVTYDSLQEMKYLGQVFDETLRMYPPAAYLNRKCERNY
EIPDGSGIIVEKGTIVAIPVLGIHYDRDYYPDPEKFDPEHFSEENKRLRPNFAFLPFGEGPRICIGMRFG
LMQSKLGLVSLLKRYKFTVSEKTREPLKMKPNSLVLSAEGEIWLDVTEIKI

CYP6BM1     Tribolium castaneum 
            GenEMBL XP_970825.1 
            52% to CYP6BK1
MAFISLTILAILLLLAVTLFYKWKFQYWKTRQVPFLPPKIPFGNIPNPFTLKEKPGIFIKQFYQEMKRNG
WKHGGFYFFACPVYMVVDPDYIKQVLIKDFQYFIDRGIYSNEKDDPISHNLFSANETKWKYLRTLLNPSF
TSKKIKAMFTILLACEKFLTQNVENNQVIDANHIFANFTIDVITTCAFGLDCNGNQNLALKHFGEKTINY
SKLKMFVLMLASIFPKLAKKFGCVIMHKNTQEFFVQFVADIIKFREENNYTRDDFMQFLIKLKNKSAKQV
FTLEEVASQCVLFFIAGFETSHATMSFALYELAKHQDIQQKVREEFWAVVDSQESEITYEAVQKLKYLDQ
VLNETLRKYPVVMYLTRRCIKDYKVPEDGAVIEKGTTVIIPTVALNYDENYYPNPKKFDPQRFSEENKKL
RHPCIHLPFGLGPRFCIGRRFALIQVKVGLVLLLKNYSFTVNPNTREPIKLKIHSFISAPEDKILLDVHKL

CYP6BN1     Tribolium castaneum 
            GenEMBL XP_969048
            50% to CYP6BK1
MNTTIEILTIIILTIFCFYKWKFSYWKSRKIPYLDPKFPFGNVSNPFFMKEKVGMTLARFYNDMKQRGWK
YGGFYFGVSPICLIVDPDLIKNIVTRDFEHFVDRGVYFNEKDDPLSGHLANLDGQKWKNMRRKLNPTFSA
SKTKNMFPIVKFCVENMMEKVKSCYENAHKCCNINEVFPAFSINVICSCAFGLQEENALFKAYADECVSW
TKYKYLVQILATFFDKTAKRMGITTVPRNAAKFFMKVVTDSVKYREENDYVRSDFMQLLIEMKKQNQLTI
EEIAAQCFVFFIAGFETSSATLTFALYELAKNQNLQNVARDEILANCPNEITYDSLADLKFLDQVVDETL
RKYPPLLYVTRQCVKNYKIPDEDVVIEKGTLVAIPISALHSDEEFYPKPETFEPERFSKTEKSLRHPYTF
LPFGEGPRMCIGKRFGLLEVKLALTCLLKNYKFSVNCKTKEPLAMRVDTVVLAPKDEIWLDLEKI

CYP6BP1     Tribolium castaneum 
            GenEMBL XP_970699
            49% to CYP6BN1
MILLVLSVVLLVALRIFFFWRFQYWEKLQIPYLRPYCPFGCLPNPLINKEKGGIILKRLYRNVRDKGWKH
AGIFVFVTPVYLPTNLDYIKNILTKDFEHFDDRGLYYNEKDDPLSGHLINLGGPKGVTMRKKLNSLFTPS
SLKMMFQTLNTSIEDLLQQIHSRNTIDIHKLFTCFTIHVIASCTLGLECNIFKEEHLLFESYANKFLVWS
RGKWCLQLLAAMYIDTARKLKVRTVPKETEDFFVKIVTKNIKYREENDYFRQDMMQFFIEQKNANTMSIN
EIIAQCFIFFIAAYETSTTTLTFALYELAQNLDIQDRVRREITSVLLKHQKYSYEAIAEMKYLNQIVDET
MRKYPPFLYVVRRCTKDYTIPGEDVTIKKGIFALISILGIHHDEEIYPNPQKFDPDRFSKENKKMRHPYA
YLPFGEGPRICIGKRFALMQIKFGLAALLEKYKFTLNEKTKVPLEIRTDTLVVAPKGDVLLDIQKIN

CYP6BP2P    Tribolium castaneum 
            GenEMBL AAJJ01000994 pseudogene
            between 6BM1 and 6BP1
14792 GSGYRGFYVFVTPVYLPTDLNYVKNILTNDFNYFNRRGIYYNEKDDPLGAHLINLSGKKK 14971
14972 HILRK 14986
15032 MIKAHKVAATFTIDIIFSCTLGLDCKTFKDKHSLLQYFLNKCLFWSKFRWFVQVLAAMN 15208
15209 GSVKQNKQNFFLEIVSILNIARK*LRE
15276 NNYVRKDLQMLINQKKSNAFSVSEITAQCLPFFDAGFDTSAATLTFALT 15422
      EIAKNLEVQEIIRAEIGEINYEILLETRYLDQVID 15526
15571 KTLRKYPPVLFVPRRCCDDYRTP 15639
      SSIVIEKGTFVLISIFGI 15709
15710 HHDQESAKFDPERFCRENKKLRHPYAYIPFGEGPRS*IG 15826
15871 KRFGLMQIKFFVASISKNYKLTKNPRTPEPLTIEVDRMVLLP*NDIFLDLVKVD 16032

CYP6BQ1     Tribolium castaneum 
            GenEMBL XP_975578
            60% to CYP6BQ11
            gene model too long at N-term shorten it
MNYTFLA
LFVTFLLGVISYLKWKLRYWDKKGLPTIPPKLPFGNLTDVIFGRKSFGEQFVEFYQILKAKGYRHGGIYF
GASPLYVPTDPEIVKHIMLVDFAHFSSHGGYVDEESDPLSGHLFNLDDIKWRNLRVKLTPTFTSGKMKMM
FQTLAEVSYNLKNVLDESVINKTPVDARDVLSRFGVDVISSVAFGLECDSLKDPNVSFRKYGKKAVDFDI
WVRIKLFMQVLLPHCVLRAIGHKFTKTEVEEFFMKSIRDVVEYREKNNIFRKDFMHLLIQLKNLGTVTDD
GQILDETSGSKEVGLTMNQVAAQAFVFFMAGYETSSSTITFALYELAMNPPLQDKLRDEINTILAKHDNK
LTYAAMMEMTYMEKVIQETLRKYPPLPIIMRLCTKDYVVPGTDIEIKKGVGVMIPVLGLQTDPEYFPDPD
VFDPDRFSEEKKKERPGFTWLPFGDGPRICIGMRFGMLQSKVALTTFIRNYRVKLNEKTKIPLKIDKGSF
TTRAEGGVWLNLEKLN

CYP6BQ2     Tribolium castaneum 
            GenEMBL XP_975576
            95% to CYP6BQ4
MLLVNGSLTYDLVAILVTVLAGLVVYYKWAFTYWKKRGLEYLEPSIPFGNCASLFKAKYNFGEQFAEFYK
QFREKNLRHGGVFMFARPFYIPVDPAIMKDIMQKDFQHFVDRGFYVNEEIDPLSGHLFSLEGNKWKNLRA
KLTATFTSGKMKMMFETMSRCAEELDNYVNEASKRKETIDIKETLARFTTDIISSCAFGLESNCLKNPDT
KFRYYGKRTFQNTTWENLKNLIQFMTPMYLLNLVKFKTTKQDVEDYMLNLVKKTVDYREKNNVYRKDFLH
LLLQLKNKGKITDDETFLDNNNKSKEVALTINELAAQVFVFFAAGYETSSTAMTFTLYELCLNQKIQDKM
REEIKTVLAKHNNKISYEALMEMTYMEQALNETLRKYPPVPFLNRKCTKAYDVAGTNLHLDEGTMVVLPI
LGLQHDPEYYPDPSKYDPDRFSEENKNSRPPFTWMPFGEGPRICIGLRFGMLQAKVGLATLLENYKVTLS
QKTKTPLEMDCKTFITTTKEGIWLDFTRLN

CYP6BQ3P    Tribolium castaneum 
            GenEMBL XP_975574, AAJJ01000063.1
            87% to CYP6BQ5
            12 P450s on this contig
            14kb region XP_975572
NFHHFMNHGNYFDSENDPLTGHLFNLEDNK*KNLRVKLTPTFILGKIK
12032 MMFQTLADCASGPNTIMDEAAKNQTSLDIKDILARFTTDVIGSVAFGLECNSLKDPDVEFRKFGKRIFQI
DVLDRIKILLQLIFPRNVLQTMKMKTTKSEVKAFFMKAIRDTVNYREKNNIYRKDFMHLLIQLTNRGVVT
DDGNITSDQSKTDKALSLNELAAQVFVFFIDRFETSLTTMI 12574 
YEIASNPQVQEKL*EEIVTTLSKYNGELSYNAIMEMTYME
LRKYPPLPLLTRQCTKDY
DPEYHP
RFNPERFSEENKKKRPNFT*ILFGE
GLRFEILQSKVGLTTLLRNLKLL*TKKNKVPLEMDKKAFVSSAEGG
VWIDVEKL

CYP6BQ4     Tribolium castaneum 
            GenEMBL XP_975572
            95% to CYP6BQ2
MLLVNGSLTYDLVAILATVLAGLVVYYKWAFTYWKRRGLEYLEPSIPFGNCASLLKLKYSFGEQFAEFYK
QFREKNLRHGGVFMFARPFYIPVDPAIMKDIMQKDFQHFVDRGFYVNEEHDPLSGHLFSLEGNKWKNLRA
KLTATFTSGKMKMMFETMSKCAEELDNYVNEAAKREETIDIKETLARFTTDIISSCAFGLESNCLKNPDT
QFRYYGKRTFQNTTWENFKDVIQFITPTYLLDLVKFKITKPDVEDYMLNLVKKTVDYREKNNVYRKDFLH
LLLQLKNKGKITDDETFLDHNNKSKEVALTINELAAQVFVFFAAGYETSSTAMTFTLYELCLNQKIQDKL
REEIKTVLAKHNNKISYEAIMEMTYMDQALNETLRKYPPVPVLNRKCTKAYDVAGTNLHLDEGTMVVLPI
LGLQHDPEYYPDPSKYDPDRFSEENKNSRPPFTWMPFGEGPRICIGLRFGMLQAKVGLATLLGNYKVTLS
QKTQTPLEMDCKAFITTTKEGIWLDFTRLN

CYP6BQ5     Tribolium castaneum 
            GenEMBL XP_975570
            65% to CYP6BQ11
            added lower case seq to gene model
MNTLLHNFVYDFVALFATVLIGVLLYYKWKFTYWAKVGLPTLAPTFPFGDAKEVMLGRLTFGEQFLEFYK
KFRANGFKHGGVYFCLQQFYVPVDPEIIKHIMQKDFHHFMNHGNYFDSENDPLSGHLFNLEDNKWKNMRV
KLTPTFTSGKIK MMFQTLADCASGLNTIMDEAAKNQTSLDIKDILARFTTDVIGSVAFGLECNSLKDPDA
EFRKFGKRIFQIDVLDRIKILLQLIFPRNVLQTMKMKTTKSEVEEFFMKAIRDTVNYREKNNVYRKDFMH
LLIQLKNRGAVTDD gnitsdqsktdk
ALSLNELAAQAFVFFIAGFETSSTTMT FALYEIASNPQVQEKLREEIVTTLSKYNG
ELNYNAMMEMTYMEKVIFETLRKYPPLPLLTRQCTKDYLIPNTTIRLKKGDMVGIAAQALHYDPEYHPDP
EKFDPERFSEENKSKRPDFTWIPFGEGPRLCIGLRFGMLQSKVGLTTLLRNYKIALNKKTKVPLEMDKKA
FVSSPEGGVWLDVEKLE

CYP6BQ6     Tribolium castaneum 
            GenEMBL XP_975569
            75% to CYP6BQ7
MTFMTESLIFDIVTIISTIVVLTIAFWKWKLSYWDRVGLPTLSPILFFGDTKDVLLGRLTFGEQFQELYK
KLKAKGLKHGGVYLGTRPFYLPTDPEIIKHIWQKDFQHFVNHGNYFDEEADPLSGHLFNLEDAKWKNMRV
KLTPTFTSRKMKMMFQTLADCTHGLKDIMDEGASSGSPVDIKEILGRFTTDIIGSVAFGLECNSLKDPNT
LFRMYGKKIFELSTGRRLHLFLQFILPERVLHAMKFKVTPSDVETFFMKVIRDTVGYREKNNVYRKDFLH
MLIQLKNRGTVTDDEKITEDNGKTGEKALTMNELAAQSFVFFAAGFETSSTTVTFALLELALNQDIQQKL
REEINTCLAKSNGELTYQAIMEMTYMDKVLQETLRKYPPVPFLTRRCTKDYTIPETSIKLRKGDHVGISV
VGIQNDPEYYPDPEKFVPERFNEENKNSRHPFTWMPFGEGPRICIGLRFGMLQSKVGLAALLKNYKITLN
SKTKMPIEMEKSSFITSVNGGVWLNVEKLS

CYP6BQ7     Tribolium castaneum 
            GenEMBL XP_975568
            75% to CYP6BQ6
MLFSDSLIVDLVTIIST IVVVSIAYCKWKLSYWNNTGLPTLSPVFPFGDTKELLLGQKSFGEQFQDLYKE
IRAKGWKHAGVYLAIQPFYLPVDPKIIKHIWQVDFQHFVNHGNYINEEVDPLSGHLFNLEDAKWKEMRVK
LTPTFTSGKMKMMFQTLADCTHGLKTIMNECATSGTPIEIKDVLGRFTTDIIGSAAFGLECNSLKDPDST
FRKYGKKVFELQGWERIKVLAQFALPHSFLRAIKFKQTQSDVEKFFMKVVRDTADYREKNKIYRKDFMHL
LLQLKNRGKVSDDEKVTQENGKTGEKALTMNEVAAQAFVFFLAGFETSSTLMTFTLYELATNPDIQGKLR
EEINTVLAKHDGQMTYEAMMEMTYMEKVLNETLRKHPPIPFLFRRCTKDYTIPETSVKLRKGDDVGISIV
GIHNDPEYYPNPEKFIPERFNEENKNARPPFTWIPFGEGPRICIGLRFGMLQSKVGLTALLKNYKISLSS
KTKMPLEMEKSGLVTTVEGGMWLNVEKIN

CYP6BQ8     Tribolium castaneum 
            GenEMBL XP_975567
            75% to CYP6BQ11
MLLNNFTLNILAVFITVLVGVIVYFKWHLSYWDRLGVPSLSPVLFFGDTKNLILSKCTIGEQFRVFYNKF
KSKGYKHGGIFFGPIPFYIAIDPEIIKHILQKDFQHFMNHGYYINEEDDPLTGHLLNLENVKWKNMRAKL
TPTFTSGKMKIMFQTLADCTTGLKKVMDDSALNHTPVDIKDIFGRFTTDIIGSVAFGIECNSLENPDAEF
RKYGKKVFEIDFFGRIKTLCTFAIPHPILRLFRFKFYNSDVATFFMDAIRETVNYREKNNIYRKDFMHLL
LQLKNRGLVTDDEKITGDKDIVTEALTMNELAAQAFVFFLAGFETSSTAMTWALYELAINPDVQQKLRAE
INDVLRKHNKLTYEAMMDMTYMEKVICETLRKYPPIPVLTRKCTKDYTIPNTSIQLQRGVSVSVPVLALH
TDPEYYPNPEKFDPDRFNDENVKARPGFTWLPFGEGPRICIGLRFGLLQSKVGLTAVLKHYRIKLNHKTQ
LPVTLNPRSFITSAKGGVWLDVEKID

CYP6BQ9     Tribolium castaneum
            No accession number
            Dr. Reddy Palli
            Submitted to nomenclature committee Feb. 5, 2008
            97% to CYP6BQ9P except it is not a pseudogene

CYP6BQ9P    Tribolium castaneum 
            GenEMBL AAJJ01000063 
            between CYP6BQ8 and CYP6BQ10
            78% to CYP6BQ11
            lower case = possible duplication or intron seq, one stop codon
            possible pseudogene
25815 MTLITNNLMFDLIAILATVLVCVIAYLKWHLTYWNRLGVPSLNPVLFFGDATDYLFGKCGVG
EQFAKFYGKFKSKGYKHGGVFLGPKCYYVPVDPDLVKHIMQKDFQHFMNHGFYINEEVDP
LTGNLFSLEDAKWRNMRVKLTPTFTSGKMKMMFQTLADCTRGLKEIMDNLALNHAPADIK
EILGRFTTDIIGSVAFGIECNSLKNPDAEFRKYGRKIVETGFIDRIKVFLVLSIPHALLR
FLRFKFTNTEVETFFMGAIQDTVNYREKNSVYRKDFMHLLLQLKNRGLVADDEKITDDKG
NIKENDFITINQLAAQAFVFFLGGFETSSTTMSWAL*ELATNQDIQEKLRKEINDVLSRH
NNKLSYDAMMEMTYMDK virhnnklsydammemtymdk VIN (1)
ETLRKYPPLPIIPRVCNKDYTI
PNTSTKLSRGTSVAIPVLAIHTDPEYYPNPEKFDPEHFSEENIKSRPGFTWLPFGDGPRICI (1) 27220
27307 GMRFGMMQSKVGLATILKNYKIKLNNKTEFPIKVDPKNFITTAKGGVWLDVEKLD* 27480

CYP6BQ10    Tribolium castaneum 
            GenEMBL XP_975564
            87% to CYP6BQ11
MTLITNNITLDLVAIIATFLVGIIVYFKWQLSYWDRLGVPSLNPTLVFGDFKNYIFAKCSLGEQFKELYD
QFKSKGYKHGGVFVGPKPFYVPIDPEIVQHIMQKDFHHFMNHGNYFDENADPLSGHLFNLEDSKWKNMRV
KLTPTFTSGKIKMMFQTLADCTRGLDEIMYNSALNHAPADIKDILGRFTTDIIGSIAFGIECNSLKNPDA
EFRKYGRRVFEVGIIDRIKIICILALPDSVLRLLKLKFTKSDVENFFMNAIRDTVNYREKNNIYRKDFMH
LLLQLKNRGSVTDDEKVTDDKDNVKEKALTLNELSAQAFVFFLAGFETSSTTMTWALYELATNQDVQEKL
RNEINNVLSRHDNKLTYEAMMEMTYMEKVIHETLRKYPPLPILTRKCNKDYTIPNTCIKLRRGTTVAIPV
LGLHTDPEYYSNPEKFDPEHFSEENVKSRPGFTWLPFGDGPRICIGLRFGMLQSKVGLTAILKNYKVTLS
NKTKFPVTLDPKSFITTAKDGIWLDVKKLD

CYP6BQ11    Tribolium castaneum 
            GenEMBL XP_975563
            87% to CYP6BQ10
MSLITDNLTFDLVAILATILVGIIVYFKWQLSYWDRLGVPSLNPVLFFGDIKDFILAKCTLGEQFKEFYG
KFKSKGYKHGGIFLGPKPFYVPIDPELVKHIMQKDFQHFVNHGNYFDEDADPLSGHLFNLEDAKWKNMRI
KLTPTFTSGKIKMMFQTLADCTRGLKEIMDHSALNHAPADIKDILGRFTTDIIGSVAFGIECNSLKDPDA
EFRKYGRKVFEVGFIDRLKTICILSLPHPVLRFFKLKFTKSDVEKFFMSAIRDTVNYREKNNIYRKDFMH
LLLQLKNRGFVADDGKVTDEKENVKEKALTLNELSAQAFVFFLAGFETSSTTMTWALYELATNQDVQEKL
RNEINNVLSRHDNKLTYEAMMEMTYMEKVIHETLRKYPPLPILTRKCNKDYTIPNTSIKLSRGTAVGIPV
LALHTDPEYYSNPEKFDPEHFSEENVKTRPGFTWLPFGDGPRVCIGLRFGMLQSKVGLTALLKNYKIKLS
KKTELPIKLDPKSFITTAKGGIWLDVEKLD

CYP6BQ12    Tribolium castaneum 
            GenEMBL XP_975562
            65% to CYP6BQ6
MAIFTSSIFIDIITIITTVLALTIAFFKWKLTFWEKLGVPTLNPVLFFGDAKNILLGKRQVGVEFIDYYK
QFKPRGLKHGGVYLGPRPFWVITDPGLIKHILQIDFPHFINHGTYADEENDPLSAHLFSLEGTKWKNMRT
KMTPTFTSGKMKMMFQTLVDCTPGLKDIMDEHASKKKAVNIKNILERFTTDIIGSVGFGIECNSLKDPDS
LFPKYGKKVFDLTPAEQLKQSLLFFLPNPVLKAMKFRITNKDVEDFFMKTVRETVLYREKNNIYRKDFMH
LLLQLKNRGTVTDDEKIIDHSNQKQEPALTMNELTAQAFVFFLAGFETSSTTMTFALYELATNPDIQEKL
RNEICTVLEKHNNELTYNAIAEMTYMDQVLHETLRKYPPLPILQRQCNKDYIVPETNIRIPKGVDVAITI
LALHRDPEFYPNPEVFDPERFNEENKNARTPFTWLPFGDGPRVCIGLRFGMMQSKVGLTALLKDYRVTLN
KKTKVPLEMSKNSFIIAAEGGIWLDIEKINT

CYP6BQ13v1  Tribolium castaneum 
            GenEMBL XP_967146
            54% to CYP6BQ4
MAILTYSWLLDIFGILTALIAVFIAWAQWSHTYWSRRNLIAPKTTFFLGNSKGIVTQKQSFGDFTVEMYE
YIRKHNKPHGGFYLTLMPNYMPVDPEIIKHIMLNDFDHFVDRGIYYNEEVDPLSAHLFSLDGAKWRNLRI
KLTPTFTSGKMKMMFDTLVKCSDQLLVEMNQTAGKAPVDAKNILARFTTDIIGSCAFGIECNSLKNPNDE
FTQYLKLFFVEGFWQNLNGIITFVAPELAKKLNMKVVNPVLSNFFMKVVEDTVNMRERNNIYRKDFMHLL
LQLKNRGELVDDDSILQNNTDAENKEVTLTLNELAAQAFVFFLAGYETSSTTMTFCLYELASNPEIQDKL
RAEINEVLQKHGKLTYDAIMEMRYMDKVVNETLRKYPPLPGLNRVCNKEYKVPGTDFVIEKGTKIWIPVL
GLHRDPEYFPNPEKFDPERFTEENKRQRHPYTYLPFGEGPRICIGLRFGMMQTKVGLSVLLKNYKFSINS
KTKLPLQLDPKSFIMSTEGGIWLDYTRV

CYP6BQ13v2  Tribolium castaneum (red flour beetle)
            No accession number
            Xu Yongqiang
            Submitted to nomenclature committee Sept. 14, 2008
            98% to CYP6BQ13v1, 9 aa diffs, 53% to CYP6BQ4

CYP6BQ14P   Tribolium castaneum 
            GenEMBL AAJJ01000098 
            70% to 6BQ11
            Frameshift in last exon, 
            one stop codon, no start, possible pseudogene
ISLGTTAYLVVLELGIALLVIVISYLKWRMTYWQKLGVPTLNPAMLFGDTKKMFLGECTF
GEQFLDIYNKFKARGVKHGGVYLGIKPFYLPLEPELVKHIMQNDFEHFVNHGLYMDKEND
PLSGHLFNLEDEKWKNMRNKLTPTFTSGKLKMMFQTLANCTVGLQTIMDDADTNHTPLDI
KDILGRFTTDIIGSVAFGLECNSLKDPDALFRKYGRKVFEMDIWERLKMFTQFVLSHRVL
RAIKFKV*KNDVERFFMKVIKDTVEYREKNNVSRKDFMHLLLQLKNRGSVTDDDKVTDDH
GKAQEKALTLNELSAQAFVFFIAGFETSSTTMTFALFELSTNPHIQDKLREEINQVLEKY
DDKLTYDAMMELTYMEKVIN (1)
ETLRKYPPAPVLFRRCNKDYKVPNTSIIIQKGIDVAIPVLGLHTDP
DYYPNPEDFDPERFSEDNKNKRPGFTWLPFGEGPRVCI (1)
GLRFGVLQTKVGLTALLKNYRVKLSPKTKMPLKMDKT
LLTSAEGGIWLDMEKLN

CYP6BQ15   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-8
           56% to CYP6BQ6 Tribolium castaneum
           48% to CYP6BW2
           65% to short fragment CYP6BU1 Leptinotarsa decemlineata DQ631653

CYP6BQ16   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-18
           50% to CYP6BQ10 Tribolium castaneum, 81% to CYP6BQ17

CYP6BQ17   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-19
           47% to CY6BQ11 Tribolium castaneum, 81% to CYP6BQ16
           68% to CYP6BQ18, 56% to CYP6BQ15

CYP6BQ18v1   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           96% to CYP6BQ18v2 possible variant of CYP6BQ18v2
           2 aa diffs in 51 aa overlap

CYP6BQ18v2   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-17
           51% to CY6BQ11 Tribolium castaneum
           93% to CYP6BQ19
           70% to CYP6BQ16, 68% to CYP6BQ17, 58% to CYP6BQ15

CYP6BQ19   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-20
           62% to CYP6BQ2 Tribolium castaneum, 93% to CYP6BQ18

CYP6BQ20   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-11
           55% to CYP6BQ10 Tribolium castaneum
           57% to CYP6BQ15

CYP6BQ21    Dastarcus helophorides (parasitoid beetle)
            KC683903
            Haidong Wang
            Submitted to nomenclature committee on Dec. 13, 2012
            53% to CYP6BQ5 Tribolium. Top 14 hits are all CYP6BQ

CYP6BQ22    Dastarcus helophorides (parasitoid beetle)
            KC683904
            Haidong Wang
            Submitted to nomenclature committee on Dec. 13, 2012
            61% to CYP6BQ13v1 Tribolium

CYP6BQ23   Meligethes aeneus (pollen beetle)
           No accession number
           Christoph Zimmer
           Submitted to nomenclature committee Nov. 27, 2011
           61% to CYP6BQ19

CYP6BQ24   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           96% to CYP6BQ17 possible variant of CYP6BQ17

CYP6BQ25   Meligethes aeneus (pollen beetle)
           No accession number
           Christoph Zimmer
           Submitted to nomenclature committee July 13, 2012
           86% to CYP6BQ23 Meligethes aeneus (pollen beetle)

CYP6BQ? Or CYP6BU?  Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-3
           72% to CYP6BU1 Leptinotarsa decemlineata C-term
           69% to CYP6BQ15
           too short to name yet.

CYP6BR1     Tribolium castaneum 
            GenEMBL XP_969875
            59% to 6BR2
MNIPSPYFEILGTVLALLVAIIFYYHHAFQFWARKNIPFIPPRFPLGNTNVVLPRGLTIGLLSKTFYDYF
KQRGHKIGGVFLVTEPNLMILDPDYIKNILLKDFHHFVDRGFYFNEKTDPISANLFTIDGDQWRNLRTKL
TPTFTSSKMKIMFQTVKNCCNNMLEAIASNTDLDKDLKEFLGRYTVDVVGSCAFGIECNSFKHPDAEFRK
MGLRAFHFSFLRSIRAFFIAYLPKLSRQMGLPSNNKDIREFFYKVVMETIQKREETQIKRNDFLQILMDL
RKTEILSLDEVAAQVFLFFTAGFETSSSTMAMCLYEIAKEPEYQEKLRQEICEITNGEITYENLFEMKYL
DQVFSETLRKYPPGQTLNRRCVKDYTLPGTSTIIEKGTPILISAIGVHRDPEYYPDPEKFDPERFSEENK
KLRHPFVYLPFGDGPRNCIGMRFGTMQSKLGIASVVKNFKVSVSPITKRVELDPNTFLLNTIDKIYFRVE
KIVK

CYP6BR2     Tribolium castaneum 
            GenEMBL XP_969813
            59% to 6BR1
MGLFLEDFWTEVFFLLTTLAILVLSYFHNAYKYWEKRGVPTIKPTFPLGNGDTLLPEGFSVGMLSRKFYE
ELKKRGEKFGGVYLVTQPNLVLVDPEYVKDILATDFQYFVDRGFYFNEKTDPLSAHLFALDGTSWRNLRI
KLSPTFSSGKMKMMFKTVLECCGYMRDYIEDILDKDLDIKEIFSRYTTDVIGSCAFGIECNSFKYPDAEF
RKMGKKVFSFGLWRSICSFCIIYFPNLSYHLGVPTNEKDVQNFFRGIVAESVNTRKEQNIKRNDFLQLLI
DLKDHSALSLNEMAAQVFLFFAAGFESSSTTMTFVLYELAKHPDIQQELRNEIRKTLDKHQGQLTYEAVM
EMKYLQQVIDETLRLYPPLATLNRRCIKDYTLRNTGIKIEKGTSVIIPSLGLHMDPELYPDPEIFNPDNF
SEENKKKRPSFVHLPFGDGPRNCIGLRFALMQSKCGIATVVNNFRFSLSPATKPLRLNPNSFVLNTYDKI
YLRAERLAM

CYP6BR3     Tribolium castaneum 
            GenEMBL XP_969746, AAJJ01000871.1
            59% to 6BR2
            gene model is too long, revised
MSVFTEFWPQILVFLALFLLVLVNYFNYCYRYWSKKGVATIKPRFPLGNTNIILPQGLSIGILSKQFYDE
FKAKGHKFGGVYLVTEPNLLIVDPEYVKDIMSKDFQHFVDRGFYYNKEKDVLSAHLFAIDGSDWRNLRIK
LTPTFTSGKMKMMFEAVVQCSKHMIENLDKNLGSDIEIKEVLGRFTTDVIGTCAFGIECNSFKYPDAEFR
MMGKKIFEYDLWKSVKAFFAVNVPKVALQLGLTSTPDDVIDFFTRIVADAVKMRESNNIRRNDFLQILID
LKNTTSLTLDEMSAQVFLFFVAGFETSSTTMTFALYELARNEKMQEKLRFEICQVLDKTGGQITYESLIE
MKYLQQVID (1)
38219 ETLRMYPPLPTLNRRCTKDYVLRDTNIIIEKDTPILISALGLHMDPEFFPKPEKFDPERFT
EEKKKERHPFVHLPFGDGPRNCI (1) 38470
38524 GLRFGVMQSKIGIITIIKNFKLTVSSNMKPVQFNPYVFLLNINDKVLLQVGKL* 38685

CYP6BS1     Tribolium castaneum 
            GenEMBL XP_974742
            47% to 6BQ13
MESALMEAGIIFLTIVSFVYLYFKHAYTYWKARNVPQLSPTFPFGDMASVIFRRHNMGDKIKEIYDETKA
RGHKYVGLYFFSRKAFLPIDPVLIKKILAPDFQHFHDRGIYYDEENDPISAHLFSLAGPKWKNLRARLTP
AYSPGKLKFMFDTVLACGEEMADILKEIAKREGKVEIKEILARYSTDVIGCCAFGIDCNSMRNPTAEFRL
MGRRAFTQTIGDVLKMIVIRSFPRLAKLLGFGVFSPTVTGFFQRVVNETIRYREENNVTRNDFMQLLIQL
KNKGKLEGDGEEKDGAPAVGTSLTLDEAAAQAFIFFLAGFETTSTTISFALFEMARNESIRTKARTEINK
VLGKHGGKLTYEATMEMEYLDTVISETLRKYPPAPVFLRKCTKTYRVPDTDVIIEEGLSVLIPAYGLHRD
PEYFPDPETFDPDRFNEDNRSKIWDYTYIPFGDGPRICIGMRFAMIQIKIALALILKSFEFPLSEKTILP
MKMENSGIILAPIGGIWLNLIPLE

CYP6BS2   Dendroctonus ponderosae (mountain pine beetle, bark beetle)
          No accession number
          Christopher I. Keeling
          Submitted to nomenclature committee Oct. 21, 2009
          68% to Tribolium CYP6BS1 XM_969649.1
          44% to CYP6AM1 Hodotermopsis sjostedti
          43% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
          clone name DPO024_H01

CYP6BT1     Tribolium castaneum 
            GenEMBL XP_969982, AAJJ01005307.1
            45% to 6BK11
            missing C-term runs off the end of AAJJ01005307.1
MLLLAESLITLVLLLIAYYKFSFQYWKRQNVPFIQPSIPWGNYPSALKRQDNFGELVVRMYHQMKKQGHK
YFGIYLFFQPCFVPTDPKFIKLILAKDFQHFNFRNFYYNEKDDPISAHLLSLNGEKWKRLRSKLTPTFTA
GKIKMVFKIFVECGKIIEHTLEHHAQNRTSFDVKEMFSSYSTDVIVNCAFGVEVDRLKKTEFKNYSQKAL
DFNTRRCIVMYLGAVFPKLCRKLGFRQIAKSAGDFFINIVRNTVEFREKTNTIRNDFLQLLINLKNDESD
DWGQFSIEEVAAQCFIFFLAGFETSATTMSFALYEIAANPHVYEQIMDEMRRVLDKYNGEMCHDAIKEMT
YLGQVVDETLRIHSPAYAVSRTCTQDYHVPETNIVLKKGFQVLIPIRGIHSDPEFYPEPEKFKPERFHPD
NRQNIEPYSYLPFGEGPRICIG 48

CYP6BU1     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P6AA56104
            65 amino acids from heme to end
            48% to 6BJ1, 54% to 6BQ6 = XP_975569

CYP6BV1     Ips pini (pine engraver, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            41% to Cytochrome P450 6BQ1 [Tribolium castaneum]
            clone name EST 24D01

CYP6BW1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            48% to Cytochrome P450 6BQ7 [Tribolium castaneum]
            clone name EST MPB3B10

CYP6BW1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee Oct. 21, 2009
            100% to CYP6BW1 of Sandstrom
            clone name DPO079_G21

CYP6BW2     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on August 28, 2006
            Full length sequence
            65% to 6BW1 
            clone name #2, EST DPG14E01

CYP6BW2     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            100% to the Sandstrom sequence
            clone name DPO1127_B15

CYP6BW3     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee Oct. 21, 2009
            96% to CYP6BW1 Dendroctonus ponderosae 
            clone name DPO049_N22

CYP6BW4     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            96% to CYP6BW2
            clone name DPO0410_N13

CYP6BW5v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH3-1
            92% to CYP6BW3 Dendroctonus ponderosae
            99% to CYP6BW5v2

CYP6BW5v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH3-2
            92% to CYP6BW3 Dendroctonus ponderosae
            99% to CYP6BW5v1

CYP6BW5v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6I-1
            98% to CYP6BW5v2

CYP6BW5v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6I-2
            98% to CYP6BW5v2

CYP6BW6     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            57% to CYP6BW1 Dendroctonus ponderosae

CYP6BX1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Missing some 5' sequence
            47% to Cytochrome P450 6BQ12 [Tribolium castaneum]
            clone name EST MPB1F02

CYP6BX1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee Oct. 21, 2009
            99% to CYP6BX1 Dendroctonus ponderosae  
            only 2 aa diffs at N-term, same gene
            clone name DPO095_N14

CYP6BY1     Aedes aegypti (yellow fever mosquito)

CYP6BY2     Culex pipiens

CYP6BY3     Culex pipiens

CYP6BY4     Culex pipiens

CYP6BY5     Culex pipiens

CYP6BY6     Culex pipiens

CYP6BY7     Culex pipiens

CYP6BZ1     Aedes aegypti (yellow fever mosquito)

CYP6BZ2    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 32
           50% to 6P4 Anoph., 64% to 6BZ1 Aedes

CYP6BZ2     Culex pipiens

CYP6CA1     Aedes aegypti (yellow fever mosquito)

CYP6CB1     Aedes aegypti (yellow fever mosquito)

CYP6CB2     Aedes aegypti (yellow fever mosquito)

CYP6CC1v1   Aedes aegypti (yellow fever mosquito)

CYP6CC1v2   Aedes aegypti (yellow fever mosquito)

CYP6CC2    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 35
           53% to CYP6CC1 Aedes,  44% to 6AD1 Anoph.

CYP6CC2     Culex pipiens

CYP6CD1     Aedes aegypti (yellow fever mosquito)

CYP6CD2     Culex pipiens

CYP6CD3     Culex pipiens

CYP6CE1v1   Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
            EF421245.1
            Jiang Hongbo
            Submitted to nomenclature committee on Jan. 31, 2007
            48% to 6AM1 
            The psocid Liposcelis bostrychophila is often found infesting 
            flour in households.

CYP6CE1v2   Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
            EU266572
            1 aa diff to CYP6CE1v1, DDVP resistant strain

CYP6CE1v3   Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
            EU266573
            6 aa diffs to CYP6CE1v1, phosphine resistant strain

CYP6CE2     Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
            No accession number
            Jiang Hongbo
            Submitted to nomenclature committee on April 7, 2007
            74% to 6CE1 
            The psocid Liposcelis bostrychophila is often found infesting 
            flour in households.

CYP6CF1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-3, 40% to CYP6N5
            Pediculus genome site

CYP6CG1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-6, 44% to 6CE1 psocid, Liposcelis bostrychophila, 
            55% to CYP6CG2
            Pediculus genome site

CYP6CG2     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-9i, 44% to 6CE1 psocid, Liposcelis bostrychophila, 
            55% to CYP6CG1, incomplete, missing N-term and last exon on C-term
            Ph6-4f probably the C-term to CYP6CG2
            54% to 6CE1 psocid, Liposcelis bostrychophila, 91% to 6CG3
            Pediculus genome site

CYP6CG3     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-10i, Ph6-5f these probably join together
            90% to louse EST CB887363,
            Pediculus genome site

CYP6CG4     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-7, 
            53% to 6CE1 psocid, Liposcelis bostrychophila, 54% to 6CG1
            Pediculus genome site

CYP6CH1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-8 
            39% to 6CE1 psocid, Liposcelis bostrychophila, 
            40% to 6BK4 Tc, 60% to 6CH2
            Pediculus genome site

CYP6CH2     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph6-11 
            45% to 6CE1 psocid, Liposcelis bostrychophila, 60% to 6CH1
            Pediculus genome site

CYP6CJ1     Pediculus humanus humanus (body louse)
            No accession number
            Reed Johnson and Barry Pittendrigh
            Submitted to nomenclature committee March 14, 2007
            Ph345
            47% to CYP6K1 Blatella germanica, 45% to 6CG2
            Pediculus genome site

CYP6CK1     Philotrypesis sp1 (Hymenoptera: Chalcidoidea: Agaonidae) 
            non-pollinating fig wasp
            No accession number
            Liu Ying
            Submitted to nomenclature committee Aug. 4, 2007
            48% to CYP6BK5 Tribolium, 49% to CYP345B1 Tribolium
            49% to CYP345A2 Tribolium, 47% to CYP6AS8 Apis
            partial seq from I-helix to heme. Name may need revision later.

CYP6CK2P   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK3    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK6    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK7    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK8    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK9P   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK10   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK11   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK11-de3b6b   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK12   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CK13   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CL1    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP6CM1v1  Bemisia tabaci (whitefly)
           GQ214539
           Shai Morin
           Submitted to nomenclature committee Dec. 3, 2007
           36% to many CYP6 subfamily sequences as in CYP6AM1

CYP4CM1v2  Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           2 aa diffs to CYP6CM1v1

CYP6CM2    Trialeurodes vaporariourum (whitefly)

CYP6CM3    Trialeurodes vaporariourum (whitefly)

CYP6CM4    Trialeurodes vaporariourum (whitefly)

CYP6CN1    Plutella xylostella (L.) (diamondback moth, Lepidoptera)
           GenEMBL EU189053.1 (incorrectly named CYP6B38), 
           GenPept ABW34440 (incorrectly named CYP6B43)
           Jihyeong Baek
           submitted to nomenclature committee Dec. 3, 2007
           48-50% to CYP6Bs, 50% to CYP6B2

CYP6CN1    Plutella xylostella 
           Gene number CCG008489.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Complete, 97% to CYP6CN1, 8 aa diffs, 4 on the ends

CYP6CP1    Culex pipiens

CYP6CQ1    Culex pipiens

CYP6CQ2    Culex pipiens

CYP6CR1    Dendroctonus ponderosae (mountain pine beetle)
           No accession number
           Claus Tittiger
           submitted to nomenclature committee Feb. 17, 2009
           39% to 6BQ2, 41% to CYP6BQ7 Tribolium
           note the names CYP6CR1 and CYP6CS1 have been swapped
           to correct a bookkeeping error on my part

CYP6CR1     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee April 30, 2010
            100% to the Tittiger sequence
            clone name DPO076_J20

CYP6CR2    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           71% to CYP6CR1 Dendroctonus ponderosae (mountain pine beetle)
           40% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
           clone name DPO023_A01

CYP6CR3     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            84% to CYP6CR1 Dendroctonus ponderosae, 93% to CYP6CR4

CYP6CR4     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            82% to CYP6CR1 Dendroctonus ponderosae, 93% to CYP6CR3

CYP6CS1    Nilaparvata lugens, Homoptera: Delphacidae (brown planthopper)
           FM994118
           Zhifan Yang
           submitted to nomenclature committee Jan. 20, 2009
           ~40% to 6F1
           note the names CYP6CR1 and CYP6CS1 have been swapped
           to correct a bookkeeping error on my part

CYP6CS2.a  Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           N-term, 74% to CYP6CS1 Nilaparvata lugens

CYP6CS2.b  Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           mid region, 82% to CYP6CS1 Nilaparvata lugens

CYP6CS2.c  Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           C-term, 87% to CYP6CS1 Nilaparvata lugens

CYP6CT1    Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_P450-6 
           37% to CYP6BK4 Tribolium

CYP6CT1    Heliconius melpomene (common postman butterfly)
           No accession number
           Ritika Chauhan and Richard ffrench-Constant
           Submitted to nomenclature committee Feb. 9, 2011
           64% to CYP6CT1 Zygaena filipendulae
           renamed as an ortholog, formerly CYP6CT2

CYP6CT1    Plutella xylostella 
           Gene number CCG013017.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Complete, 56% to CYP6CT1 Zygaena filipendulae
           renamed as an ortholog, formerly CYP6CT3

CYP6CT1    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012
           renamed as an ortholog, formerly CYP6CT4

CYP6CT1    Helicoverpa armigera (cotton bollworm)

CYP6CT1    Chilo suppressalis (striped rice stem borer)

CYP6CU1    Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP6CV1    Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
           No accession number
           Zhifan Yang
           submitted to nomenclature committee June 13, 2009
           41% to CYP6B8v1 Helicoverpa zea
           37% to CYP6AE28 Cnaphalocrocis medinalis

CYP6CV2    Plutella xylostella (L.) (diamondback moth)
           No accession number
           Selina Zhang
           submitted to nomenclature committee Nov. 10, 2010
           52% to CYP6CV1

CYP6CV2    Plutella xylostella 
           Gene number CCG002723.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Complete, 99% to CYP6CV2 3 aa diffs 

CYP6CW1    Nilaparvata lugens, Homoptera: Delphacidae (brown planthopper)
           No accession number
           Zhifan Yang
           submitted to nomenclature committee June 13, 2009
           35% to CYP6N1

CYP6CW2    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 76% to CYP6CW1 Nilaparvata lugens

CYP6CW3    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           mid region, 71% to CYP6CW1 Nilaparvata lugens mid region

CYP6CX1v1  Bemisia tabaci (whitefly)
           No accession number
           Lin Zheng and Gang Wu
           Submitted to nomenclature committee June 10, 2009
           Resistant strain, 2 amino acid differences to the susceptible strain
           49% to CYP6CM1 Bemisia tabaci

CYP6CX1v2  Bemisia tabaci (whitefly)
           No accession number
           Lin Zheng and Gang Wu
           Submitted to nomenclature committee June 10, 2009
           Susceptible strain
           49% to CYP6CM1 Bemisia tabaci

CYP4CX1v3  Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           3 aa diffs to CYP6CX1v2

CYP4CX2    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011

CYP4CX3    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011

CYP4CX4    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011

CYP4CX5    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011

CYP6CY1    Acyrthosiphon pisum (pea aphid)
           LOC100159226.pro    SCAFFOLD10025:26656..31321 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           82% to LOC100163313.pro (adjacent), 
           77% to LOC100168115.pro (2 genes away)
           CYP3 clan
MFTASWWINVITPCTIIVTITYYFCVSTFKKWEKLNVPYIKPIPLFGNFLNVALGKNHPLEFYNKIYHEFAGQKYAGVFQMRTPYLMVRDPEIINDVMIKNFSSFPDRGIYSDFVAEPLTNNLLLMENPQWKIIRNKLTPAFTAGKLKTMYDQIKECGDELMKNIDIDLNRTSNEIEVKDIMGKYSTDVIGTCAFGLKLNAINDDESPFRKYGKLIFKPSLRVLMRELCVMITPALLKVVRLKKFPTAATDFFHAAFNETMTYRLENNIVRNDFVHYLMQARNDLVLNTDLPKHEKFAESQIVANAFVLFAAGFETVSSAISYCLYELALNKSIQDRVRKEIQLQLSKNNGQINHELLIDLNYLDMVIAETLRKYPPLVALFRKASQTYRVPNSSLIIEKGQKIIIPIYAIHYDNKYYSDPEKFIPERFSAEEKAKRPSGVYLPFGDGPRICIDSEWLRNVLMLQ

CYP6CY2    Acyrthosiphon pisum (pea aphid)
           LOC100163313.pro    SCAFFOLD10025:31376..37086 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MFTANWWINFITPCTIIVTIAYYFCVSTFKKWEKLNVPYIKPIPLFGNLLNVAVGKDHPLDFYNKIYHKFAAHKYAGVFQMRTPYLMVRDPEIINDMLIKDFSSFPDRGIYSDFVAEPFSNHLFFMENPQWKIIRNKLTPAFTSGKLKMMYDQIKECGDELMKTIDIELIKNDDEIEVRDIIGKYSTDVIGTCAFGLKLNAIKDDESPFRKHGKTLFEPSLRALFKELCLMIAPALLKVIKVKDFPTDATDFLHTVFKETITYRQKNKIVRNDIFQCLIQVRNDLVLNADLSKNEKFTETQIVANAFAMFAAGFETVSSAISYCLYELALNKSIQDRVREDIELKLSNNDGQINHELLIDLNYLDMVIAETLRKYPPVVALFRKASQTYRVPNDSLIIEKGQKIIIPIYALHYDSKYYTDPEKFIPERFSAEEKAKRPSGIHLPFGDGPRICIGKRFAEMEMKLAFVEILTKFEVFPCEKTEIPLKYSNKVFTLMPKHGIWLRFKRIN

CYP6CY3    Acyrthosiphon pisum (pea aphid)
           LOC100168115.pro    SCAFFOLD10025:41696..46319 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           37% to CYP6A14, 38% to CYP6Y1, 39% to CYP6AQ1 bee
           42% to CYP6AX1
           CYP3 clan
MAYDLNEIKIKLNYVNIINVIIVVLYHYLFKIRFREKKYAEKYPLIEFDTKRENSVDSCVFCVGTLFNIQNCVNYRKGHMYPSSSSATDWWIYIVTPCLVAVTITYYFCISTFNKWEKLNVPYIKPIPLFGNFLKVALAKDHPLEFYDKIYYKFSGLKYGGLFQMRTPYLMVRDPEIINNMLIKDFSSFPNRGIYSDLAANPLSDNLFFMENPRWKTIRSKLTPAFTSGKLKIMYDQIKECGDKLMKNIDNDLKGKNDEIEVRDIMGKYSTDVIGTCAFGLKLNSISDDESPFRKYGKSIFIPSLRTLFRELCLMVSPALLKVVRVKDFPTDATAFFNAAFKETITYRLENKIVRNDFVNCLMQARNDLTLNTNLPKHERFSESQIVANAFVMFAAGFETTSTTLSYCLYELALNIHIQDKVRQEIQLKLSKSDGQIDNEFLMGLNYLDMVIAETLRKYPPLIALFRKASQTYRLPDNLILEKGQKIVIPIYSIHFDSKYFEDPLKFNPERFSSEERAKRPNCVYLPFGDGPRTCIGKRFAELEMKLALVEMLTKFEVLPCGKTEVPLKYSNKALTLMPKHGIWLRFKKIV

CYP6CY3    Myzus persicae (green peach aphid)
           no accession number
           Chris Bass
           submitted to nomenclature committee March 4, 2010
           88% to CYP6CY3, next best match is 79% to CYP6CY4
           this is the apparent ortholog of CYP6CY3 of pea aphid

CYP6CY4    Acyrthosiphon pisum (pea aphid)
           LOC100164042.pro    SCAFFOLD10025:137606..141395 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           87% to LOC100167264.pro, 85% to LOC100163313.pro
           80% to LOC100168115.pro 90kb downstream of LOC100168115.pro
           CYP3 clan
MFTANWWINVITPCTIIVTIAYYFCVSTFKRWEKLNVPYIKPIPLFGNFLNIALGKDHPLEFYNKIYYEFAGRKYGGLFQMRTPYLMVRDPEIINDVMIKDFSSFPDRGIYSDFTANPLSNNLFFMENPQWKTIRNKLSPAFTSGKLKTMYDQIKKCGDELMKNIDIDLNKNGNEIEVRDILGKYSTDVIGTCAFGLKLNAISDDESPFRKYGKSIFTPSLRMLFRELCLMITPALLKVIRVKDFPTAATDFFHAAFKETMTYRIENKIVRNDFVHCLMQARNDLVLNTDLPKHEKFTETQIVANAFVMFAAGFETVSTTVSYSLYELALDKSIQDRAREEIQLKLSKNDGQINHEFLMDLNYLDMVIAETLRKYPPLVALFRKASQTYRIPNDSLIIEKGQKIIIPIYAIHYDTKYYPEPEKFIPERFSVEEKAKRPSGIYLPFGDGPRMCIGKRFAEMEMKLAFVEILTKFEVFPCEKTEVPLKYSNKVLTLMPKHGIWLRFNRIN

CYP6CY5    Acyrthosiphon pisum (pea aphid)
           LOC100167264.pro    SCAFFOLD13514:28216..31057 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MFTANWWINVITPCTIIVTIAYYFCVSTFKKWEKLNVPYIKPIPLFGNFLDIALGKAHPLEFYGKIYNEFAGRKYGGLYQMRTPYLMVRDPEIINDMLIKDFSSFPDRGIYSDFVANPLSNGLFFMENPQWKIIRNKLTPAFTSGKLKTMYDQIKECGDELMKTIDMDLIKNGKEIEVRDIMGKYSTDVIGTCAFGLKLNAINDDESPFRKHGKSIFTPSLRSLFRELCLMVTPALLKVVRVKDFPTDATDFFHAVFKETITYRLENKIVRNDFVQCLIQARNDLVLNADLPNHDFVLEKFTESQIVANAFGMFAAGFETVSSTISYCLYELALNKSIQDRLRKEIQLKLSKNDGQINPEFLMDLNYLDMVIAETLRKYPPLVALFRKASQKYRLPNDSLIIEKGQKIIIPIYALHYDNKYFTDPENFIPERFSAEEKAKRPNGIYLPFGDGPRICIGKRFAEMEMKLAFVEMLTKFEVFPCDKTDIPLKYSNNVITLVPKHGIWLTFKRIN

CYP6CY6    Acyrthosiphon pisum (pea aphid)
           LOC100165240.pro    SCAFFOLD13514:36706..45131 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           downstream of LOC100167264.pro
           CYP3 clan
MFTDNWWIYVITPCTIIVTIVYYFCVSTFKKWENLNVPYIKPVPLFGNFLNVALGKEHHIDFYNKFYHKFAGHKYAGVFQMRLPILMIIDPEIINDVLIKDFSSFPNRGFSVDFKANPLSNNLFLMENPQWKIIRNKLTPAFTSGKLKVMYDQIKECGEELMKNIDIDLKKSGDEIEVRDIMGKYSTDVIGTCAFGLKLDAINDDESPFRKHGKSIFAPSLRQLFREMCMLISPVLVKVVRVKDFPKDATDFFHAAFKETMKYRHENKIVRNDLVHCLMQARNDLVLNTDLPKHEIVLEKFTESQIVANAFIMFAAGFETVSSAISYCLYELALNKSIQDRVREEIQLKLSKNDGQINHEFLMELHYLDMVLAETLRKYPPLVFLMRKALQTYRLPNDSLTIEKDQKVIIPVYAIHHDSKYYPEPENFIPERFSTEEKAKRPNGTYMPFGDGPRICIGKRFAEVEMKLAMVEMLTKFEVFPCEKTEVPLKYSHKTITLMPKHGIWLKFKKIN

CYP6CY7    Acyrthosiphon pisum (pea aphid)
           LOC100160895.pro    SCAFFOLD17283:187176..190201 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MIDVISCSIIGLLSSVYILYATVFLSIAYYLCTSTHDKWRKLNVPYTKPLPLFGNSMNLVLAREHPMDFFTGLYNRFPDEKLCGFYQMTTPFLMIRDPKLINNIMVRDFSYFTDHGFDTDPSVNILANSLFMLNGDRWRTMRQKLSPGFTSGKLKDTHDQIKECTDQLINIVDDNLKVSDHFEIRELVGNFSTDVIGMSAFGLKLDTIRNGNLDFRKFGKKIFQSDFKQLFVQAMMLFCPKLVTILKLKQFPDDAADFYGSMFRDVLEYRDRNNVIRNDVTQTLIQAKKDLVTNNDGDDSTSKNKWTEMDIVGNAILMFVAGAETVSITICFCLYQLALNKDIQDKLREEIVTTNAKHGGQLNNDFLTNLHYMNMVLEEVSRMYSITMILFRQATKNYEVPGQSLVIEKGQKIIIPAYCIHNDPKYYPNPGTFDPERFSTEEKAKRLNGTYIPFGDGPRLCIGKRFAELEMKLVLSKILLKYEVLPCEKTEVPINIRGAGSIVNPKNGVWLSFKPIVAN

CYP6CY8    Acyrthosiphon pisum (pea aphid)
           LOC100159248 SCAFFOLD5532:14697..15575 (- strand) 
           and SCAFFOLD5532:7975..9925 (- strand) (seq gap in middle of gene
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MLIFANFWMDFIILVTVLFSIIYYYCTSTFNVWKKLNVPYVRPIPLFGNYLKVALGIENPMETYKNIYYELAGFQYGGMFQMRTPYLMIRDPEIVNNILIKDFSYFTDRGIHVDFKAEPLSEVLFLMENPRWKKLRSKLSPAFTSGKLKQMYSQIEKCGQDMIINIFAELKKNPNEIDIRDILAKYSIDVIGSCAFGLALNVASDDTSLFRSYGKTAFSETLRKYPLLFALFRVATKTYRVPNDSLIIEKGQKIIIPTFSLHFDPRYFSDPEVFNPERFSTKEKAMRPNGVYLPFGDGPRLCIGKRFAEMEMKLALVEILSKFEVEPCEKTEIPIQFSKLSVVVIPKDEKILLKLNPLSE

CYP6CY9    Acyrthosiphon pisum (pea aphid)
           LOC100161627 SCAFFOLD1099:1136..6561 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MSASQLLVDLAAGWWTVAVLALLAATVYHFCTSTFGYWRDRGVPYVRPTVPLFGNIGGLALGVEHQARMFGRIYDGFRGQRYGGFFQMRTPHLMVCDPALVNRVLIGDFAHFTDHGMYTAGPDENPLANGLFNMNGAQWKIMRQKLSPVFTAGKLRHMRGQVTECSEQLMRNVAADVPAGGGQMEIRDVLGKYSTDVIGTCAFGLHLNAINDERSSFRKHGKAVFAPSFRVLLKELAWMVTPALRRALRIGDMPPDAAQFFTAAFTDTMKYREEHGIVRDDFMQSLIQARTDLVVNKTEPSVEFLETDIVANAFILFAAGFETVSTAMSFCLYELALKKPIQDKVREEMNTTKKKHNAEIDNDFLKDLHYLEMVLAETLRKYPPLLTLFREATQDYQVPDDTFVIEKGTKVLIPAYAIHHDYRYYPDPETFDPERFSPEEKAKRPNGTYMPFGDGPRLCIGKRFAEMEMKLALTELLTTYEVEPCEKTDIPMRFSKRSLIITPENGIWLKFKPIHTSK

CYP6CY10P  Acyrthosiphon pisum (pea aphid)
           LOC100159387 SCAFFOLD6634 coords:14145-18091 (- strand) pseudogene
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           upstream part not found in region up to next gene
           47% to CYP6A13, 48% to CYP6AQ1 C-term only CYP3 clan
           67% to LOC100168007.pro
           CYP3 clan
MESQILSNAFGFFAAGFDTTSTSISYCLYELALKKNIQDRVREEIKLTKSKYNGVIDNEFLNDLHYLDMVIAESLRKYPLMFALFRVATKTYRVPNDSLIIEKGQKIIIPTFSLHYDPKYFSDPEVFNPERFSPKEKAMRPNGVYLPFGDGPRLCIGKRFAEMEMKLALVEILSKFEVEPSEKTMIPVQFSKLSVVVIPRDEKILLKLNPLSE

CYP6CY11P  Acyrthosiphon pisum (pea aphid)
           SCAFFOLD12002:AUG4_SCAFFOLD12002.g13.t1 pseudogene
           SCAFFOLD12002:309999..313284 (- strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           86% to LOC100163195.pro not in the submitted gene collection
           CYP3 clan
MISCLIDFLLGTPAIAVTVLMAFVYYYTTNTYDKWLKLNLRYDPPWPLVGNTMKMVTLIE HQLATIDGIYKRLAGEKYCGFYQTKTPFLMIRDPELINNILIKDFLNFANRGFHKDPALN IIANGLFFMEGPKWDVMRQKLSSGFTSGKLKLAHNQIAECSDELMRFIAAKMKENDQIEVK
*TMSKYSTDVIGTCAFGLSL

CYP6CY12   Acyrthosiphon pisum (pea aphid)
           LOC100163195.pro 
           SCAFFOLD12002:306085..309474 (- strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           39% to CYP6AX1
           CYP3 clan
MISCLIYVLFGTPAIAAVAVLAAILYYYTTNTYDKWLKLKVPHDPPWPLVGNTAKMMTLIEHQLTTIDGIYKRFSGEKYCGFYQMKTPFLMIRDPELINNILIKDFSNFADRGFHKDPALNIIANGLFFMEGPKWKMMRQKLSPGFTSGKLKLAHNQIAECSDELMRFIAAKMKENDQIEVK ETMSKYSTDVIGTCAFGLKLDTVKNEGSDFRLYGRKILKLSFRFLLAEMVSPKILKLLGVAEFPPDASAFYESAFKEVIRYREENGIVRHDVAQSLIEARKELVLDSTDENGFTEQHIIANAILMFLAGFETVSSTLSFCLYHLALNQDVQEKIRDEMNSKLKQHGKINNDFLVNLHYTDMVLAETERMYVVTNALFREAVKTYHVPGDTLVIEKGTKIMIPIYSIHHDPTYYPEPYIFDPQRFSPEEKAKRQSSTYLPFGDGPRFCIGKRFAELEMKMVLSQIITTFRILPCEKTEVPLKLQNGLPMMVAKNGIWLRFQSISE

CYP6CY13   Acyrthosiphon pisum (pea aphid)
           LOC100167704.pro    SCAFFOLD7563:47979..58025 (- strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           only P450 on this 60 kb contig
           CYP3 clan
MISWMFNCLIDSFTLICTTVIGLLFYYYSTSTYKKWRKANVPHTKPVPFFGNFFRSTLGFETINDTYHNIYKQFPDKKFCGFYQMRTPTLMIRDPELINNVLIKDFSHFTDHGLDMDPSVNFLASSLFFTRGQKWKIMRQKMSAGFTSGKLKLMHSQIKDCSKEMIDYIDRKSKTTDQFDMHDIMNKYATDVIGTCAFGLKLGSMKDEDNEFRKFTKLLFKPSFRLIFTNILSLISPKTSNILKIKTSSPEVMEYFTTSFQNVIEYREKNNMDRNDVAQTLMRARKELKFTEMDIISNAILMYLAGAEPVSDTLGFCLHELAINKHVQDKLRKHINTKRKEHGGEFTNDYLMDLHYADMVLTETLRKCNGTIVLFRKATKAYQVPDSSLVIEKGQQIIIPTYSIHHDPKYYTNPDVFDPERFSPEEKSKRPSSTELLFGDGPRFCIGKRLAELEMKLGLSEIISKFEILPCEKTENPVQLANAGGAIKPKNGIWLI 

CYP6CY14   Acyrthosiphon pisum (pea aphid)
           LOC100161480.pro    SCAFFOLD8603:3827..8475 (- strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MISYLTNLLFDYIFLSLIIVCTFLYYYTTSTYDTWRKLNVPFAKPVPFFGNIFKMFTGLERQVDAFGRIYQQFPDEKFCGFYQMSTPFLMLRDPELINTVIIKDFSYFTDHGIDMNPSVNVMARSLFFATGQKWKTMRQKLSPGFTSGKLKGTHEQIRECSDQLTNCIYEKSQKTDAIEVYELVGNTATDVIGTCAFGMKLDTINNDNSSFRQNVKKVFKPSGKVIFAQILGVLFPKIVKFLKLQTSPVDVDAVNFFHSVFGEVIEYRTKNDVVRNDLTQTLMKARQDLVVSSDYKGEEKYCELDIIANAMLLFTAGSETVTATASFCFYELALNKVIQDRLRDEIISSKIKHGGQLNNEFLEDLHYADMVLDXXIEKGQKILIPIYSIHHDPKYYPNPETFDPERFTAEEKSKRPNGTFLPFGDGPRHCIGKRFAELELKLILSKILTKFEISPCEKTEIPLQMNKERGITSPKNGIWLNFRPIVE

CYP6CY15   Acyrthosiphon pisum (pea aphid)
           LOC100163900.pro SCAFFOLD5222 coords:2410-5346
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MYFLTDWLLDNFTYLSLIAVFTGFYYYSTSTYGKWQKLNIPYIPPVPLFGNAFRMVTKLECPMDMYDRLYKQFPDVKLLGFYQMTEPMLLIRDPELINAILIKDFPYFTDHGFVMDPSTTVMAKSLFFSNGQRWRTMRQKLSPGFTSGKLRDTYLAINECSNQMVSSIVEKLGKTDRLAIRSIISGFSNDVIGMCAFGIQLDSMNNEDSDFRRYSERIFEKTTKQIIVQAVTTIFPFVINLFKIQMFSAEATNFFRKVFADVINYREKNNIVRNDLTQTLLQARKELVLKENSTAEGIVFADQFTDDDIIGNAIVLFADGAETISSIVSFCLYELALNKEIQDKMRAEICSMKAKHDGQFNNDFLMDLRYTNMVLEETGRKYSIASILMREATKTYTLPDESFVIEKGQKLIIPMFSIHRDPKYYPDPLIFDPERFSKEQKSQRPNGIYMPFGDGPRMCMGKRFAELEMKLVLSNVLSKFEVLPCEETEIPLEITDETGVIAPKRDLVLKFRPIIED

CYP6CY16   Acyrthosiphon pisum (pea aphid)
           LOC100162372    SCAFFOLD1019:69426..73624 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MISFMTDWLHDNVTCLSLIAVLASFYYYSTSTYGKWRILNIPYVPPVPLFGNTTRMMLRLEHPIDMFERFYNSFPDVKLFGFYQMRDPVLLVRDPELINAILVKDFSYFTDHGIDLDSSTSVLANSLFFANGQKWRTMRQKLSPGFTSGKLKDTHGQINECSDEMVSGIVESIKKKTDQIDVKTITGGFSTDVIGTCAFGMKLDTIKNDDSDFRRYVKIMFQSTPKQMIVQVLLMICPWVIKVLKINMFSVEATNFFHNVFTDVFKYREEHNVIRNDLTQTLMQARKELVLKENSSIEDKFTDADIIGNAILMFTAGSETISSMLSFCLYELALNIEIQDRLRSEICSMKAKHDGHLNNDYLMDLYYTNMVLEETARKYSIAFNLMRVATKTYTLPDESFVIEKGQKLIIPMFSIHRDPKYYPDPLRFDPERFSTEQKSQRPNGIYMPFGDGPRLCIGKRFAESEMKLVLSNVLSKFEVLPCEKTEIPVNIRSMSGFITPKNGIVLKFRPIVEH

CYP6CY17   Acyrthosiphon pisum (pea aphid)
           LOC100164459mod.pro (N-term trimmed) 
           SCAFFOLD2510:85936..93942 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           CYP3 clan
MNDIKLLNGLVSGAVDSPDLLSRIGFRIPDKYSNRKRPLPLNKPIMISFLIDCLVNNVTCLSLIVIFTGSFYYYSTSTYNKWRKLKIPYVPPVPLFGNTFRMLARLEHPIDTFDKIYNHFPDFKLFGFYQMREPMLLVRDPELINMILVKDFLYFTDHGVDIDPSMSTLAKSLFFANGQKWRTMRQKLSPGFTSGKLKGTYCQINECSDEMVSSIVEAIGKKTDRIELKTITGRFSTDVIATCAFGLKLDSIKNGDSEFRRYVKILFQTTTKQAIILILSLICPRVVKILRLQFFSLEATNFFSKVFADVIKYREDHNVSRNDITQTLIEARKELVLKEISTTEDKFTDDDIIGNAIFLFSAGSETISSLVCFCLYELALNKEIQDKLRAEIYSMKAKHNGKLNNDYLVDLRYTNMVLEETGRKYSIAFNITRVATKTYTLPDESFVIEKGQKLIIPMFNIHRDPKYYPDPLRFDPERFSMEQKSQRPNGTYIPFGDGPRLCIGKRFAEAEMKLVLSKVLSKFEVQPCEQTEIPLDIRSGSGLLSPKNGLVLKFKPIIEH 

CYP6CY18   Acyrthosiphon pisum (pea aphid)
           LOC100168007.pro    SCAFFOLD1502:67256..70800 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           39% to CYP6AX1
           73% to LOC100164042.pro
           CYP3 clan
MHRTTLISLGGLFMHNINLLSNNIIVSVVKMSLYNLYLYCLYGCNVIYKLDKFSGITIYHNENPSSIQYRITNDIFTLYLMKIAEANAVLTLAYVKLVVFCVFLIMFSFIFIWWINIITPCLFIFTITYYFCTLTYSKWEKINVPYIQPIPLFGNFLDVALGMQHPIDFYRKIYYELAGYKYGGLFQMRTPYLMIRDPEIINNVLIKDFSNFPNRGIYSDFSANPLSNQLFFMENPQWKIIRKILSPAFTSGKLKLMYDQIKECGDELMKNIHKNLTKTDNKMEVRDILGKYSTDVIGTCIFGLKLNAVSDDNSTFRKYGKSLFLPSLRTHLRELSLMITPALLNILRFKDFPADATEFFHSAFHETITYREKNNIVRNDFVQTLIQARNDLVLNKNIPQRERFLESQIVANAFVMFAAGFETVSTAISFCLYELSFCLYELSLKKHIQDKVREEINLKLSKNNGLINNDLLIDLNYLDMVLAETLRKYPPTFALFRKASQTYHVPNDSLTIEKDQKVIIPIYSLHYDPKYFADPEVFDPERFSPEEKSKRISGTYLPFGDGPRICIGKRFAELEMKLALVEILTKFETEPCERTEVPIRFSKKALITMPENGIWLTFKKITNQ

CYP6CZ1    Acyrthosiphon pisum (pea aphid)
           LOC100165972.pro   SCAFFOLD1502:79066..88489 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           downstream of LOC100168007.pro, 46% to LOC100168007.pro
           CYP3 clan
MFEFVYELFDLKMLLVTAFLGAIYVYSTWTHSHWSKLGISSPSAPVPLFGHAMPSMLGQMHFMDVLHNLYKELGDQRFGGIYTMRTPQLLVKDPELIGHILIKDFNNFTDRGLYAGTHTNPLNNNIFFTRGERWKTMRQKLSPTFTANKLKYMNEQVKECSDGLLSTIGKNLDDDAGRIEIREMMAKYSTDVIGSCAFGLKLDAINDPDSEFRKHGKTVFQPSLRSKIRVAVIFMQPSLLSIFRVHHYSHRTIRFFHDAFQQTIEYREKHNEDRKDFVQHLMKAREDLVLNPNLKPE
EKFTEMDIVANAYILFIAGFETVSTSMSFCMYELALRKDVQDKVRKEILEVKSKYNGQMNSECLNELHYMGMVIKETLRKYPPLVTLNRVVTKPYVIPGTQIKLKIGTKIVVPVHAIHYDPKYYSDPEAFEPDRFSDENIHNIQPNTYMPFGDGPRFCIGKRFAEFEMKMALSEVLTNYEVMACDKTQIPIKYVIGSFVNIPESVWLKFRKVNT

CYP6DA1    Acyrthosiphon pisum (pea aphid)
           LOC100159636.pro SCAFFOLD17790 coords:18123-22112
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           41% to CYP6AX1
           CYP3 clan
MSGVWSIPFVQLCAAAVLLVTFLGYMYLTYHYGKWTGLGVPHAAPSPPFGSLRDVVMGRVPLVDAIHSLYRRFDGQRYFGIYEGRQPLLVVCDPQLVHTIMVKDFRSFVDRNAGKVSFVHDKLFDHLVNLRGEQWKAIRAKLSPTFSAAKLKSMLGDINVCTARLIDNLNGQITKNSGIVDVSEASAQFTTDTIGSCAFGLDCNALSNPDSEFRRTGRAIFTPSLRSNLLNITRLVGFGRLLDVFRIRGMSGNIYDFFDNLLDTTMEQHKSGENTRNDFIALLVKLKDEEKQKEHGQKLFTDDILAANSFVFFVAGFETTASTISYCLYELAMNPEIQVKLRENIKKTLDANDGKLAYDTLKDMKYLDMVINETFRLHPPVPVLNRVCTQKYTITDSNITLNVGDKLIIPTYSLHHDSKYYSDPEIFDPERFTEENISSRPHGTFLPFGDGPRICIGLRFAMMEAKTGLAEILSKFEVSPCKETQTPIKIKPRSILLTPNESIRLSFKSIDQ

CYP6DA2    Acyrthosiphon pisum (pea aphid)
           LOC100168454.pro  SCAFFOLD17790:22986..29493 (+ strand)
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           downstream of LOC100159636.pro
           39% to CYP6AX1, 39% to CYP6a2
           CYP3 clan
MICFSCWLEIVPIAAIASALLTYVYCTRYYGHWTALGVPHTKPAPLLGHFAGPTMGRESGTITVDTLYRRFVGHRYFGVYQLRHPMLVVRDPVLVHAVLATEFGSFHDRVMSRTSFEHDGLFNSLVNLRGDKWKAVRAKLSPTFTVAKLKAMFASLHVCTGQLTDKLLLLTSGGQGIVNVTDVSSKFTIDTIGRCAFGINCNTLFDSNTEFQRAGQAVFTPTLKSSVLNFMRLIDLGWLVDLFRLRSMPDLVYEFYLNLFQDTLELRKNEKEDRNDFVSILVKLRNDEKINNSRVELFTDDVLASNAFIFFAAGFETTASAMSYCLYELALNQDIQVELRKQIQHTLNENGGILTYDVLKDMKYLDMVLNETLRMHPPGPGLLRVCTKKFKIPDSDITLDTGMKVLIPTYSLHHDPAYYPNPELFDPLRFTEDNKALRPNGTFLPFGDGPRICIGLRFALMEAKTGLAEIISKFEIFPCKYTKIPIKLNPRSILLTPNEPISLLFKQIA

CYP6DB1    Acyrthosiphon pisum (pea aphid)
           AUG5s6612g1t2 XR_045850
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           40% to CYP6K1
           missing about 60 aa at N-term (added)
           CYP3 clan
MISKEIIFVYTTCAIVVLFTAVYLYYRNIYSYWKKLGVYHLEPLFFFGNAKERVLFKKSFHEFHRD 
MYFKFKGHRYAGYYLGRRASLVILDPEIIKCIMIKDFNHFTDRQTMRFRTSEYITEMLINLKGSKWKRMRGQLTPAFTSGKLRTMEHLVDVCCNNMSDFLNENIKSEQGYDLEMKDFFGKFTLDVIATCAFGVESNSLKDVNGGFASRVSKFASLSIMKRLTLYIVLLFMPGIARFVPLSFFNMEVIQFLANVIKEAKKCRKSTGQKRNDFLQLLLDSETDLDKNDKTKSKEDVLTEAQVVAQSVLFLIAGFETSSTLLTFTCYELAINQTIQDKLREEICSVLKRFNGKCTYEAMQEMPLLDMVLMETLRMHPPVAQLERVSTQDYTLPDSNLLLKKGMTVQIPVIGLHYDPEYYPDPYKFEPYRFSPEEKAKRSHYVFLPFGTGPRNCIGLRFALMSTKRGMVHLLKDFSIDLSKEMTVPYEYSKHSMLLKAKDGIRLSFNKLSA 

CYP6DB2    Trialeurodes vaporariourum (whitefly)

CYP6DB3    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           68% to CYP6DB2 Trialeurodes vaporariourum (whitefly)

CYP6DB4    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           77% to CYP6DB2 Trialeurodes vaporariourum (whitefly)

CYP6DB5    Sogatella frucifera (white-backed plant hopper)
           No accession number
           Shi Xiaoqin
           Submitted to nomenclature committee March 25, 2011
           Clone name sf31
           58% to CYP6DB2

CYP6DC1    Acyrthosiphon pisum (pea aphid)
           AUG5s9515g6t1p 
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           41% to CYP6AM1  Hodotermopsis sjostedti
           CYP3 clan
MVFFDSSLLNLVAYGIVISTTFYFYLRYRYTFWQRQGCPVPLKPHIIYGHTKEVTKMKTWVGKHYANIYYNTDGYKFVGFYQFQKPKLMLRDLNIIKDVFTKEFSTFPNRGIVFDDKLEPLTGNLLTLEGHRWKVLRNKLTPAFTIGKIKNMIDLIDGRAQEMVRVLEKSAVIGEQVEFKELLARFSTDVISIVAFGFETNSLTNPDAEFRRVGRMLFSTSLETIIRNALNALAPSLIGLLKVRSIKKEYADFFYNVVNDTVKYREENGIQRNDFLDLLMKIKRGQNLASDEDNFKFTMDVLAAQCFVWFIGGYETSSVTLTFTFFELAQNLDVQMRAQDEIDSVLSKYDGKLTYEILQEMPYLDMIVSEALRKYPPVPNLTRKAVKPYKLPNSDFTLDKGLQVVIPVYGIHNDPEYWPEPEKFIPERFTEEEKRNRPQYAYLPFGAGPRLCIGMRFGMMQVKVALFRILSTYNISLSKSMKLPMKMNPKTIPANPDGGMFLHITKRKN 

CYP6DD1    Acyrthosiphon pisum (pea aphid)
           LOC100162594.pro  SCAFFOLD16233:102870..132505 (- strand) 
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           46% to CYP6AY1, 42% to CYP6M11
           CYP3 clan
MFPAVVIIVACCTTVILFLYKYTTYTYKYWKSKSVTFATPVPLFGNIKDHVTLKMTQGECLKNIYNDFPREKFVGMYQLQTPTLLLRDPETIRLFLVKSFAHFTDRGFSYDGHREPLTKHLVNLEGDTWKILRQKLTPTFSSGKIKSMLGLLQGCGVQLIEYMDATIESGKTEFEIRDLTAKFTTDVIGTCAFGLECNSLKDSQSEFRRMGCAVLNSSASLALAKMVRVFFPKLFKALKLRTFPAEVQQFFMGIVKQTIDFRNTNRVRRNDFIQLLLEIKNQNHNQENAIKSIELTEELIAAQVFVFFLAGFETSSTTLSFCLHEMAVNQDIQNRVYDEINETANMYGLPFSYEAISSMNYLEQCLKETMRKYPPVQALARVCTKQFRVPGTDLDLDVGTAVLIPVYAIHHDPQYYPEPDTFNPDRFAKDGDGGGGDNGRPSGVFLPFGDGPRICIGMRFAMLEMKLALAQFLHRYLVTLSDKSCTRIEFEPASFLSCPKGGIWLNVNKRKA

CYP6DE1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           99% to EZ115020 Dendroctonus ponderosae 16-AUG-2009 Tittiger
           84% to DPO047_M21
           45% to CYP6BV1 Ips pini (pine engraver, bark beetle)
           clone name DPO0814_E19

CYP6DE2    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           84% to CYP6DE1
           44% to CYP6BV1 Ips pini (pine engraver, bark beetle)
           clone name DPO047_M21

CYP6DE3    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           81% to CYP6DE2
           45% to CYP6BV1 Ips pini (pine engraver, bark beetle)
           clone name DPO089_C09

CYP6DE4    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           67% to CYP6DE2
           43% to CYP6BV1 Ips pini (pine engraver, bark beetle)
           clone name DPO0910_C07

CYP6DF1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           45% to CYP6BW1 Dendroctonus ponderosae 
           clone name DPO074_P02

CYP6DG1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           47% to CYP6BR3
           42% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
           clone name DPO0310_A06

CYP6DG1v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH4-1
            89% to CYP6DG1 Dendroctonus ponderosae (probable ortholog) 
            98% to CYP6DG1v2

CYP6DG1v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH4-2
            89% to CYP6DG1 Dendroctonus ponderosae (probable ortholog) 
            98% to CYP6DG1v1

CYP6DG1v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6F-1
            100% to CYP6DG1v4
            99% to CYP6DG1v2

CYP6DG1v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6F-2
            100% to CYP6DG1v3
            99% to CYP6DG1v2

CYP4DG2    Rhynchophorus ferrugineus (red palm weevil)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Jan. 26, 2012
           57% to CYP6DG1 Dendroctonus ponderosae

CYP6DH1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           97% to DPO123_O19
           40% to CYP6BW1 Dendroctonus ponderosae
           clone name DPO011_M04

CYP6DH2    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           40% to CYP6BW1 Dendroctonus ponderosae 
           clone name DPO123_O19

CYP6DH3    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee April 30, 2010
           68% to CYP6DH1 Dendroctonus ponderosae
           Clone name DPO143_B19

CYP6DJ1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           99% to EZ115116.1 1 aa diff EZ115116 16-AUG-2009 Tittiger
           84% to EZ116057.1 16-AUG-2009 Tittiger
           43% to DPO0310_A06
           39% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
           clone name DPO0411_I13

CYP6DJ1v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH1-1
            90% to CYP6DJ1 Dendroctonus ponderosae (probable ortholog)
            97% to CYP6DJ1v2

CYP6DJ1v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH1-2
            90% to CYP6DJ1 Dendroctonus ponderosae (probable ortholog)
            97% to CYP6DJ1v1

CYP6DJ1v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6H-1
            99% to CYP6DJ1v4
            97% to CYP6DJ1v2

CYP6DJ1v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6H-2
            99% to CYP6DJ1v3
            98% to CYP6DJ1v2

CYP6DJ2    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee April 30, 2010
           82% to CYP6DJ1 Dendroctonus ponderosae
           clone name DPO1016_M18

CYP6DJ2v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH2-1
            93% to CYP6DJ2 Dendroctonus ponderosae (probable ortholog)
            99% to CYP6DJ2v2

CYP6DJ2v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP6RH2-2
            93% to CYP6DJ2 Dendroctonus ponderosae (probable ortholog)
            99% to CYP6DJ2v1

CYP6DJ2v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6G-1
            99% to CYP6DJ2v1
            98% to CYP6DJ2v4

CYP6DJ2v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP6G-2
            98% to CYP6DJ2v1
            93% to CYP6DJ2 DPO1016_M18

CYP6DK1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           99% to EZ115020 16-AUG-2009 Tittiger
           39% to CYP6BW1 Dendroctonus ponderosae 
           clone name DPO0814_K02

CYP6DL1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig7818_21018 494aa (formerly 6DE1, but name conflict)
           44% TO CYP6CY3, in the CYP3 clan

CYP6DL2    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig7817 395aa  (formerly 6DE2, but name conflict)
           40% to CYP6AX1, 87% to contig7818, in the CYP3 clan

CYP6DM1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig9338_22180 501aa (formerly 6DF1, but name conflict)
           40% TO CYP6A2, 79% to contig22179, 51% to CYP6X1, in the CYP3 clan

CYP6DM2    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig22179 347aa (formerly 6DF2, but name conflict)
           47% to CYP6X1 Lygus lineolaris, in the CYP3 clan

CYP6DN1    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig20497 560aa  (formerly 6DG1, but name conflict)
           38% TO CYP6CE2 Liposcelis bostrychophila, 90% to contig22672, 
           62% to contig10526, 57% to contig10525, in the CYP3 clan

CYP6DN2    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig22672 511aa (formerly 6DG2, but name conflict)
           35% to CYP6M11, in the CYP3 clan

CYP6DN3    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig10526 515aa (formerly 6DG3, but name conflict)
           35% TO CYP6BQ13 Tribolium, in the CYP3 clan

CYP6DN4    Cimex lectularius (bedbug)
           No accession number
           Zach N. Adelman
           Submitted to nomenclature committee Dec. 1, 2009
           contig10525 477aa (formerly 6DG4, but name conflict)
           37% TO CYP6BQ13 Tribolium, in the CYP3 clan

CYP6DP1    Trialeurodes vaporariourum (whitefly) 

CYP6DP2    Trialeurodes vaporariourum (whitefly) 

CYP6DP3    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           58% to CYP6DP1 Trialeurodes vaporariourum (whitefly)

CYP6DQ1 to CYP6DV3 Trialeurodes vaporariourum (whitefly) 

CYP6DV4    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           59% to CYP6DV1 Trialeurodes vaporariourum (whitefly)

CYP6DV5    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           66% to CYP6DV4 Bemisia tabaci

CYP6DV6    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           58% to CYP6DV4 Bemisia tabaci

CYP6DW1    Trialeurodes vaporariourum (whitefly) 

CYP6DW2    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           60% to CYP6DW1 Trialeurodes vaporariourum (whitefly)

CYP6DW3    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           71% to CYP6DW2 Bemisia tabaci

CYP6DX1    Trialeurodes vaporariourum (whitefly) 

CYP6DX2    Trialeurodes vaporariourum (whitefly) 

CYP6DY1    Trialeurodes vaporariourum (whitefly) 

CYP6DZ1    Trialeurodes vaporariourum (whitefly) 

CYP6DZ2    Trialeurodes vaporariourum (whitefly) 

CYP6DZ3    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           62% to CYP6DZ1 Trialeurodes vaporariourum (whitefly)

CYP6DZ4    Bemisia tabaci (sweet potato whitefly)
           JN165274.1
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           60% to CYP6DZ1 Trialeurodes vaporariourum (whitefly)

CYP6DZ5    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           60% to CYP6DZ4 Bemisia tabaci

CYP6DZ6    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           84% to CYP6DZ4 Bemisia tabaci

CYP6DZ7    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Xin Yang
           Submitted to nomenclature committee May 23, 2012
           96% to CYP6DZ6

CYP6EA1    Trialeurodes vaporariourum (whitefly) 

CYP6EB1    Frankliniella occidentalis (western flower thrips)
           EST part GQ290643
           Dina Cifuentes Romo
           Submitted to nomenclature committee Feb. 17, 2010
           47% to CYP6EC1, 40% to CYP6N6
           whole sequence known but confidential

CYP6EC1    Frankliniella occidentalis (western flower thrips)
           EST part GQ290640
           Dina Cifuentes Romo
           Submitted to nomenclature committee Feb. 17, 2010
           47% to CYP6EB1, 41% to CYP6AA5v1
           whole sequence known but confidential

CYP6ED1v1  Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-1
           40% to CYP6BK6 Tribolium castaneum
           48% to CYP6EE1
           43% to CYP6EF1
           48% to CYP6BH1v1 in 64 aa from heme region to end

CYP6ED1v2  Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           98% to CYP6ED1v1 (4 aa diffs)

CYP6ED2    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-2
           56% to CYP6F1 Culex pipiens  (aa 299-399)
           65% to CYP6ED1, 55% to CYP6EE1

CYP6EE1v1  Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-16
           39% to CYP6BK2 Tribolium castaneum
           48% to CYP6ED1
           44% to CYP6EF1
           43% to CYP6BH1v1 from heme to end

CYP6EE1v1  Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee Dec. 26, 2011
           100% to CYP6EE1v1
           complete seq.

CYP6EE1v2  Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           98% to CYP6EE1v1 (5 aa diffs)

CYP6EF1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-5
           52% to CYP6BR2 Tribolium castaneum
           48% to CYP6DG1 Dendroctonus ponderosae
           51% to CYP6BH1v1 from heme to end

CYP6EG1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-7
           43% to CYP6BK1 Tribolium castaneum, 37% to CYP6BQ15, N-term

CYP6EH1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-15
           41% to CYP6BQ2 Tribolium castaneum
           41% to CYP6CR2 Dendroctonus ponderosae

CYP6EJ1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-21
           42% to CYP6AT1 Phyllopertha diversa scarab beetle

CYP6EK1     Bactrocera dorsalis (Oriental fruit fly)
            No accession number
            Jiang Hongbo 
            submitted to nomenclature committee 9/17/2010
            48% to Cyp6a2 Drosophila melanogaster

CYP6EL1     Locusta migratoria manilensis
            No accession number
            Rongrong Yu
            Submitted to nomenclature committee Dec. 12, 2010
            49% to CYP6BQ13v1 Tribolium castaneum

CYP6EL2    Linepithema humile (argentine ant)
           No accession number

CYP6EL3    Linepithema humile (argentine ant)
           No accession number

CYP6EL4P   Linepithema humile (argentine ant)
           No accession number

CYP6EL5P   Linepithema humile (argentine ant)
           No accession number

CYP6EL6    Linepithema humile (argentine ant)
           No accession number

CYP6EL7    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           83% to CYP6EL2 Linepithema humile

CYP6EM1    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           50% to CYP6DT5v1 Trialeurodes vaporariourum (whitefly)

CYP6EN1    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           52% to CYP6DX1 Trialeurodes vaporariourum (whitefly)

CYP6EP1    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           53% to CYP6CX1v1 Bemisia tabaci

CYP6EQ1    Bemisia tabaci (sweet potato whitefly)
           No accession number
           Yidong Wu
           Submitted to nomenclature committee March 2, 2011
           50% to CYP6CX1v2 Bemisia tabaci

CYP6ER1    Nilaparvata lugens (brown planthopper)
           No accession number
           Chris Bass
           Submitted to nomenclature committee April 18, 2011
           43% to CYP6CS1 Nilaparvata lugens

CYP6ER2    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           62% to CYP6ER1 Nilaparvata lugens
           mid region

CYP6ER3    Laodelphax striatellus (small brown planthopper)
           No accession number
           Xu Lu
           Submitted to nomenclature committee June 11, 2012
           73% to CYP6ER1 Nilaparvata lugens

CYP6ES1    Linepithema humile (argentine ant)
           No accession number
           
CYP6ES2    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           57% to CYP6ES1 Linepithema humile

CYP6ES3    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           68% to CYP6ES1 Linepithema humile

CYP6ES4    Solenopsis invicta (fire ant)
           See Solenopsis page
           78% to CYP6ES3

CYP6ES5    Atta cephalotes (leafcutter ant)
           See Atta cephalotes page
           64% to CYP6ES1 Linepithema humile

CYP6ET1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           51% to CYP6N18 Culex pipiens

CYP6EU1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           47% to CYP6AG6 Aedes aegypti, top 16 hits are CYP6AG

CYP6EV1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           40% to CYP6M2 Anopheles gambiae 
           96% to CYP6EV2 mostly identical with small regions of diffs
           
CYP6EV2    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           41% to CYP6M2 Anopheles gambiae 
           96% to CYP6EV1 mostly identical with small regions of diffs

CYP6EV3    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           41% to CYP6M2 Anopheles gambiae 
           58% to CYP6EV4, 58% to CYP6EV2, 56% to CYP6EV5, 57% to CYP6EV1

CYP6EV4    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           43% to CYP6M3 Anopheles gambiae 

CYP6EV5    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           41% to CYP6M3 Anopheles gambiae 

CYP6EW1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           43% to CYP6AA3 Anopheles minimus 
           61% to CYP6EW2

CYP6EW2    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           43% to CYP6AA9 Culex pipiens 
           61% to CYP6EW1

CYP6EX1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           42% to CYP6M2 Anopheles gambiae

CYP6EY1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           43% to CYP6N2 Anopheles gambiae

CYP6EZ1     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011

CYP6FA1     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            51% to CYP6AE33 Heliconius melpomene

CYP6FA2     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            62% to CYP6FA1 Heliconius melpomene

CYP6FB1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           46% to CYP6BQ7

CYP6FC1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           53% to CYP6CR2 Dendroctonus ponderosae

CYP6FD1    Locusta migratoria manilensis
           No accession number
           Yanqiong Guo
           Submitted to nomenclature committee Aug. 5, 2011
           78% to CYP6FD2, 46% to CYP6AM1

CYP6FD2    Locusta migratoria manilensis
           No accession number
           Yanqiong Guo
           Submitted to nomenclature committee Aug. 5, 2011
           78% to CYP6FD1, 45% to CYP6AM1

CYP6FE1    Locusta migratoria manilensis
           No accession number
           Yanqiong Guo
           Submitted to nomenclature committee Aug. 5, 2011
           47% to CYP6FD1, 45% to CYP6AM1

CYP6FF1    Locusta migratoria manilensis
           No accession number
           Yanqiong Guo
           Submitted to nomenclature committee Aug. 5, 2011
           50% to CYP6FD1, 46% to CYP6AM1

CYP6FG1    Locusta migratoria manilensis
           No accession number
           Yanqiong Guo
           Submitted to nomenclature committee Aug. 5, 2011
           38% to CYP6FD1, 37% to CYP6F4 Culex pipiens

CYP6FH1    Agrilus planinennis (wood boring beetle)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Aug. 23, 2011
           50% to CYP6BQ11
           note: this was attributed to Cimex before.

CYP6FH2    Agrilus (Emerald ash borer)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Nov. 10, 2011
           55% to CYP6FH1 Agrilus planinennis

CYP6FH3    Agrilus planipennis 
           No accession number
           Swapna Priya Rajarapu
           Submitted to nomenclature committee March 20, 2012
           91% to CYP6FH1

CYP6FJ1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 45% to CYP6CW1 Nilaparvata lugens

CYP6FK1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           Complete, 42% to CYP6P10v1 Ochlerotatus sollicitans
           42% to CYP6P12v1 Aedes aegypti

CYP6FL1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Yue-Liang Zhang
           Submitted to nomenclature committee Oct. 19, 2011
           36% to CYP6CW1 Nilaparvata lugens, 35% to CYP6BK6 Tribolium castaneum
           N-term 

CYP6FL2    Laodelphax striatellus (small brown planthopper)
           No accession number
           Xu Lu
           Submitted to nomenclature committee June 11, 2012
           87% to CYP6FL1 Laodelphax striatellus

CYP6FM1    Plutella xylostella 
           Gene number CCG013454.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           Complete 50% to CCG005902.4 (CYP6BG4)
           49% to 6AE12v2   Helicoverpa armigera

CYP6FN1    Harmonia axyridis (ladybug)
CYP6FN2    Harmonia axyridis (ladybug)
CYP6FP1    Harmonia axyridis (ladybug)
CYP6FP2    Harmonia axyridis (ladybug)
CYP6FP3    Harmonia axyridis (ladybug)
CYP6FP4    Harmonia axyridis (ladybug)
CYP6FP5    Harmonia axyridis (ladybug)
CYP6FP6    Harmonia axyridis (ladybug)
CYP6FQ1    Harmonia axyridis (ladybug)
CYP6FR1    Lucilia sericata (sheep blowfly)
CYP6FR2    Lucilia sericata (sheep blowfly)
CYP6FS1    Lucilia sericata (sheep blowfly)
CYP6FT1    Lucilia sericata (sheep blowfly)

CYP6FU1    Laodelphax striatellus (small brown planthopper)
           No accession number
           Xu Lu
           Submitted to nomenclature committee June 11, 2012
           45% to CYP6AX2 Laodelphax striatellus

CYP6 fragment    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-6-4
           50% to CYP6BK11 Tribolium castaneum C-term
           56% to CYP6BQ15
           49% to CYP6BJ1v1
           too short to name yet.

CYP6 fragment    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Shi Xiaoqin 
           Submitted to nomenclature committee Dec. 10, 2010 
           CYP3 clan
           Clone name seq 14
           43% to CYP6EJ1 Leptinotarsa decemlineata
           short seq before the I-helix
           
CYP6-un1   Acyrthosiphon pisum (pea aphid)
           AUG5s17796g1t1p  SCAFFOLD17796:3506..66376 (+ strand) 
           possible pseudogene
           Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
           36% to CYP6BX1 Dendroctonus ponderosae C-term no Cys
           CYP3 clan
MFVPRKNSRFSIIALSFLLRNLVADVNILAVRISFLFIPPSADVADKQVRLDMFEFVTGTIEQTAALVTGALYELARDQNIQNHLREHLDSVLDEHQEQVTIDQWXXXXXXXXXXXXXXXXXXNQTLRKYPLAAVVRRVATKPYVVPGTGGRGTIEPDSLIVVPVYELHHDAEHFTEPEKFQPHRFPGQLSSAYMPHGSGPQSYIGKHFVELEAKLVIAMLMSRYEVHVDSATPGTPPDPLDRKSFEGVRMTVANRSSVRESTMGASLRQFHMSNGVNSGDRKFLFF 

7A Subfamily

CYP7A1      human
            GenEMBL L04629 to L04634 PIR S29818 (504 amino acids)
            Nishimoto,M., Noshiro,M. and Okuda,K.
            Structure of the gene encoding human liver cholesterol 7
            alpha-hydroxylase.
            Biochim. Biophys. Acta 1172, 147-150 (1993)

CYP7A1      human
            GenEMBL L07951 (3880bp)
            Thompson,J.F., Lira,M.E., Lloyd,D.B., Hayes,L.S.,
            Williams,S. and Elsenboss,L.
            Cholesterol 7 alpha hydroxylase promoter separated from 
            cyclophilin psuedogene by alu sequence.
            Biochim. Biophys. Acta 1168, 239-242 (1993)

            Cohen,J.C., Cali,J.J., Jelinek,D.F., Mehrabian,M.,
            Sparkes,R.S., Lusis,A.J., Russell,D.W. and Hobbs,H.H.
            Cloning of the human cholesterol 7 alpha hydroxylase 
            gene (CYP7) and localization to chromosome 8q11-q12.
            Genomics 14, 153-161 (1992)

            PIR A42201 (25 amino acids)
            Molowa,D.T., Chen,W.S., Cimis,G.M. and Tan,C.P.
            Transcriptional regulation of the human cholesterol
            7 alpha hydroxylase gene.
            Biochemistry 31, 2539-2544 (1992)

CYP7A1      human
            GenEMBL L20569 (2575bp upstream region)
            GenEMBL L20570 (2317bp exons 5 and 6)
            Chiang, J.Y.L. and Wang,D.-P.
            Genomic cloning and sequencing of human cholesterol 7a-
            hydroxylase gene (CYP7).
            unpublished (1993)

CYP7A1      human 
            GenEMBL L13460 (4959bp)
            Wang.D.-P. and Chiang,J.Y.L.
            Cloning, sequencing and analysis of human cholesterol 7a-
            hydroxylase gene (CYP7).
            Genomics 20, 320-323 (1994)

CYP7A1      Pan troglodytes (chimp)
            XM_519773.2 3 aa diffs to human
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGC               ALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESVSELISLRMFLNDTLSTFDDLEKA KTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPIC LSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ LMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL

CYP7A1      Macaca fasicularis (cynomolgus monkey)
            DQ074791
            Yasuhiro Uno
            Submitted to nomenclature committee 1/11/2005
            Clone name mfCYP7A1_8F1
            94% to 7A1 human partial sequence
IFGRDLTRQDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRT
AHSAREKLAESLRHENLQKRESVSELIRLRMFLNDTLSTFDDLEKAKTHLVVLWASQA
NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQTQLNDLPVL
ESIIKESLRLSSASLNIRTAKEDFTLHLEEGSYNIRKDDIIALYPQLMHLDPEIYPDP
LIFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRVFAIHEIKQFLVLML
SYFELELVEGQDKCPPLDQSRAGLGILPPLYDIEFKYRFKHL

CYP7A1      Macaca mulatta (rhesus monkey)
            NM_000780
MMTTSLIWGIAIAACCCLWLILGIRRR (2)
QTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSY
HKVLCHGKYFDWKKFHFATSAK (0)
AFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN
SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA
LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKA
KTHLVVLWASQANTIPATFWSLFQMIR (2)
NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL (1)
DSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPL (0)
TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA
IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL*

CYP7A1      Bos taurus (cow)
            See cattle page for details
MMSLSLIWGIVIAVCCCLYLLGMRRR (2) 5259
QMGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCRLMGNYVHFITNPLSYH 3625
KVLCHGKYFDWKKFHFTASAK (0)
AFGHRSIDPSDGNTTDTISKTIIKTLQGDALSSLTEAMMGNLQLVLRPQGPPQPPTPTW 2193
VTEGMYSFCYRVMFEAGYLTLFGRDLAGQDAQKALILNSLDNFKQFDKIFPALVAGFPIH 2013       
VFKTGHYAREKLTEGLRLQKFRERDHISELVRFLNDTFATLDDTERAKSLLAVLWAS 1842
QANTIPATFWSLFQMIR
RNPEAMKAATEEVNKTLENAGQKVSFEDSPIHLNQTQLDNMPVL (1)
60 DSIIKESLRLSSASLNIRTAKEDFTLHLQDGSYNIRKDDIIALYPQLMHLDPEIYP 239
240 DPLTFKYDRYLDENGKTKTTFYSNGLKLKYYYMPFGSGVTICPGRLFAVQEIKQFLILML 419
420 SYFELELVESCVKCPPLDQSRAGLGILPPLYDTEFRYKFKHS* 548

CYP7A1     pig 
           AK230789.1 
           88% to cow 7A1
MMSISLLGGIVTAVCCCLWLLLGMR
RRQTGEPPLENGIIPYLGCALQFGANPLEFLRANQRKHGHIFTCQLMGNYVHFITNPLSY
HKVLCHGKYLDWKKFHFTASAKAFGHRSIDPSDGNTTDNINKTIIKTLQGDALNLLAAAM
MENLQLVLRPQVAPQPEKPAWVTEGMYSFCYRVMFEAGYVTLFGKDPIGHDAQKALILNN
LDNFKQFDKIFPALVAGFPIHVFKTGHYAREKLAEGLRLQKLRKRDHISELVRFLNDTLS
TLDDAEKAKSLLAVLWASQANTIPATFWCLFQTIRSPEAMKAASEEVNKTLEKAGQKISL
DDKPIYLNQIELDSMPVLDSIIKESLRLSSASLNIRTAKEDFTLHLQDGSYNIRKDDIIA
LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYSHGLKLKYYYMPFGSGATICPGRL
FAVQEIKQFLILMLSYFDLELVESHVKCPPLDQSRAGLGILPPSNDIEFRYKLKHL*

CYP7A1      Canis familaris (dog)
            XM_544091.1
MMTISLIWGIVVAVCCCLWLIFGMRRRQMGEPPLENGLIPYLGC
ALKFGANPLEFLRANQRKYGHVFTCRLMGNYVHFITNPLSYQKVLCHGKYLDWKKFHF
TTSAKAFGHRSIDPSDGNTTENINKTFIKTLQGDALNSLTEAMMENLQLVMRCPLVSK
SKTPAWVTEGMYSFCYRVMFEAGYLTLFGKDLTGQDAQKGLILNNLDHFKEFDKIFPA
LVAGLPIHVFKTAHHAREKLAEGLRHENLGKRDHISELVRFLNDMLSTLDDMDKAKTH
LAILWASQANTIPATFWSLFQMIRSPEAMKAATEEVNKTLENAGQKISLDGSPICLNQ
MQLNDMPVLDSLIKESLRLSSASLNIRTATEDFTLHLQDSSYNIRKDDIIAFYPQLVH
LDPEIYPDPLTFKYDRYLDENGKTKTTFYSNGIKLKYYYMPFGSGATMCPGRLFAVQE
IKQFLILMLSYFELELVESQVKCPPLDQSRAGLGILPPLNDIEFKYKFKHL

CYP7A1      rat
            GenEMBL U01962 (7998bp)
            Chiang, J.Y.L. and Stroup,D.
            Identification and characterization of a putative bile acid responsive 
            element in cholesterol 7 alpha-hydroxylase gene promoter.
            J. Biol. Chem. 269, 17502-17507 (1994)

CYP7A1      rat
            PIR S27206 (26 amino acids)
            Chiang, J.Y.L., Yang, T.P. and Wang, D.P.
            Cloning and 5'-flanking sequence of a rat cholesterol 7alpha-
            hydroxylase gene.
            Biochim. Biophys. Acta 1132, 337-339 (1992)

CYP7A1      rat
            PIR A35609 (26 amino acids)
            Jelinek, D.F. and Russell, D.W.
            Structure of the rat gene encoding cholesterol
            7alpha-hydroxylase.
            Biochemistry 29, 7781-7785 (1990)

CYP7A1      rat
            Lee, Y.-H., Alberta,J.A., Gonzalez,F.J. and Waxman,D.J.
            Multiple functional DBP sites on the promoter of the cholesterol 7 
            alpha hydroxylase P450 gene CYP7.   Proposed role in diurnal regulation 
            of liver gene expression.
            J. Biol. Chem. 269, 14681-14689 (1994)

CYP7A1      rat
            GenEMBL Z18860 (?bp)
            Hoekman,M.F.M., Rientjes,J.M.J., Twisk,J., Planta,R.J., Princen,H.M.G. 
            and Mager,W.H. 
            Gene 130, 217-223 (1993)
            note: promoter sequence

CYP7A1      rat
            Ramirez et al. 
            Cholesterol amd bile acids regulate...
            Molec. Cell. Biol. 14, 2809-2821  (1994)

CYP7A1      rabbit
            GenEMBL S67315 (770bp)
            Poorman,J.A., Buck,R.A., Smith,S.A., Overturf,M.L. and
            Loose-Mitchell,D.S.
            Bile acid excretion and cholesterol 7 alpha-hydroxylase expression
            in hypercholesterolemia-resistant rabbits
            J. Lipid Res. 34, 1675-1685 (1993)   

CYP7A1      rabbit
            GenEMBL L10754 (3002bp)
            Kai,M., Eto,T.,Kondo,K.-H., Setoguchi,Y., Maeda,Y., Higashi,S.
            and Setoguchi,T.
            Effects of bile acids feeding on cholesterol 7 alpha-hydroxylase
            mRNA levels in subtotally cecectomized rabbits
            J.Lipid Res. 36, 367-374 (1995)

CYP7A1      Cricetulus griseus (hamster)
            GenEMBL L04690 (10614bp)
            Crestani,M., Galli,G. and Chiang,J.Y.
            Genomic cloning, sequencing, and analysis of the hamster
            cholesterol 7 alpha-hydroxylase gene (CYP7)
            Arch. Biochem. Biophys. 306, 451-460 (1993)  

Cyp7a1      mouse
            GenEMBL L23754 (2939bp) EST AA254999
            Tzung,K.-W., Ishimura-Oka,K., Kihara,S., Oka,K. and Chan,L.
            Structure of the mouse cholesterol 7 alpha-hydroxylase gene. 
            Genomics 21, 244-247 (1994) 
MMSISLIWGIAVVVSCCIWFIIGIRRRKVGEPPLDNGLIPYLGC
ALKFGSNPLEFLRAKQRKHGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHY
TTSAKAFGHRSIDPSDGNTTENINKTFNKTLQGDALCSLSEAMMQNLQSVMRPPGLPK
SKSAVWVTEGMYAFCYRVMFEAGYLTLFGKDISKTDTQRAFIQNNLDSFKQFDQVFPA
LVAGVPIHLLKTAHKARERLAESLKHKNLYMRDQVSELIRLRMFLNDTLSTFDDMEKA
KTHLVILWASQANTIPATFWSLFQMIRSPEAMKAASEEVNGSLQSAGQELSSGGNAIY
LDQEQLNNLPVLDSIIKEALRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ
LMHLDPEIYPDPLTFKYDRYLDESGKAKTTFYRNGNKLKYFYMPFGSGATICPGRLFA
VQEIKQFLILMLSYFELELVESHTKCPPLDQSRAGLGILPPLNDIEFKYKLKH

CYP7A1    Monodelphis domestica (gray short-tailed opossum)
          DQ051398
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN
TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF
EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE
SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ
MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS
LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK
TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD
QSRAGLGILPPLNDIEFKYKFKHL*

CYP7A1      Gallus gallus (chicken)
            NM_001001753
            Christoph Handschin
            Submitted to nomenclature committee 3/27/02
            66% to human 7A1
MFIAPWIWGTVIIVCCSFWFLFGRRRRRRQGEPPLENGFLPYLG
CALQFGANPLKFLREKQKKHGHIFTCQVAGKYIHFLTDPFSYHSLIRQGKHLDWKKFH
FATSAKAFGHGSIDPAEGNTTENFHHTFIRTLQGNALDALIKAMMENLQYVMLQSRAS
KFQPNTWVTEGLYTFCCQVMFESGFLTLFGKEFNSNHDKNLSKRETERARILNALENF
KEFDKIFPALVAGLPIHLFKSAHSAREKLGEALLHKNLLKRDNLSELVMLRMFLNDTL
STFDDMEKAKTHVAVLWASQANTIPATFWSLFYLLKNPEAMRAATKEVQSVLESAGEK
ISLDGNYISLNRKQLDNMPVLDSIIKEAMRLSSASMTFRVAKEDFTLHLENSFYNIRK
DDIVALYPQLLHFDPEIYADPLTLKYDRYLNENKEEKTDFYRNGRKLKYYYMPFGAGI
AKCPGRLFAVHEIKQFLVLIFSYFEIDLVDSNVQCPSLDQSRAGLGILQPSNDIDFRY
RLKCL

CYP7A1      Xenopus tropicalis (Western clawed frog)
            scaffold_8:3335708-3339166 UCSC browser 
            5102_prot 
            64% to human 7A1 
MLTVSLIWGLVVALCCFFWLIVGIRRRQPGEPPLENGLIPYLGCALQFGA
NPLEFLRVRQNKFGNVFTCKIAGQFVHFVTDPFSFNSVMRHGRHFDWQKF
HFATSAKAFGHSNIDSSDSEVTQNVHDSFLKTLQGDALDPLISNMMENLQ
HTMLQNSSYKVNSKDWVTEGLYAFCYRVMFEAGYLTLFGKEFNSPEDKNL
ARQEAQRALILNAIENFKEFDKIFPALVAGLPIHVFKSAYSARENLAKDL
LHENLRKRNNISELISLRMFLNESMTSLNDMEKAKTHLALLWASQANTLP
ATFWSVFYLLRCPHAMKASTEEVQRVLEKASQKVNCDGRYIFLNRHELDD
MPVLDSIIKEAMRLSSASLNIRVAKENFVLHIDDKQAFNIRKDDIVALYP
QMVHLNPDIYEDPNNFKYDRYLGEDGKEKTSFFLNGRKLKYYYMPFGSGK
TKCPGRQFAVHEIKQMLTLIICYFDMELVDKNIRSPPLDQSRAGLGILQP
THDVDFRYKLKAH

CYP7A1    Danio rerio (zebrafish)
          See zebrafish pages for seq

CYP7A1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_5172
            59% to 7A1 human
14694 MILSIALIWAVVVGFCCLLWLAVGIRHR 14777 (2)
15070 HSSEPPVENGLIPYLGCALQFGANPLQFLRSRQKKYGHIFTCKIA 15204 frameshift
15205 GQYIHFLCDPFSYHSVIRQGRHLDWRKFHFATSVK 15310 (0 expected) bad boundary
15425 AFGHDSFDPRHGHTTENLHQ 15484
15485 TFLKTLQGEALPSLIKTMMGHLQDVMLKSDTLRRSKDHWEVDGIFAFCYK 15634 (0)
15757 VMFESGYLTLFGKELGEDTCQARQAAQKALVLNALENFKEFDKIFPALVAGLPIHVFKSAYSARE 15951 (0)
16053 NLAKTMHAEKLSKRENVSDLISMRMILNDSLSTFNDVSKARTHVALLWASQANTLPATFWSLFYMIR 16253 (2) 
16383 SPDAIKAAREEAQKVFETFGVKIDPHNPTLNLTRDVLDNMPVL 16511 (1)
16744 DSIIKEAMRLSSASLNIRVAKEDFLLHLDNQEAYRIRKDDVIALYPPMLHYDPEIFEDPY 16923 (0)
17029 EYKFDRFLDENNQEKTTFTRNGRKL 17103
17104 RYFYMPFGSGVTKCPGRFFAVYEIKQFLTLVLTYFDMELLDPAIQVPPLDQSRAGLGILQ 17283
17284 PTYDVDFRYKLKLAY* 17331

CYP7A1     Tetraodon nigroviridis (freshwater puffer) 
           95% TO FUGU CYP7A1
           EXON 3 FROM CAAE01017512.1
MILSIALIWAVVVGFCCLLWLAVGIRHR (2)
QSSEPPVENGLIPYLGCALQFGANPLQFLRSRQKKYGHIFTCKIA 
GQYIHFLCDPFSYHSVIRQGRHLDWRKFHFATSVK (0) 
AFGHDSFDPRHGHTTENLHQTFLKTLQGEALPSLIKAMMGHLQDAMLKSDTLSRSKDRWEVDGIFAFCYK (0)
vmfeSGYLTLFGKELGEDKCQARQEAQKALVLNALENFKEFDKIFPALVAGLPIHVFKSAYCARE (0)
NLAKTMHAEKLSKRENVSDLISMRMILNDSLSTFNDVSKARTHVALLWASQANTLPATFWSLFYMIR (2)
SPDAMKAAREEVQKVFETFGLKIDPDNPTLNLTRDVLDNMPVL (1)
DSIMKEAMRLSSASLNIRVAKEDFLLHLDNQEAYRIRKDDVIALYPPMLHYDPEIYEDPY (0)
EYKFDRFLDEKGQEKTTFTRKGRKLRYFYMPFGSGVTKCPGR FFAVYEMKQFLSLVLSYFDMELLDPAIQVPPLDQSRAGLGILQPTYDVDFRYKLRSVY*

7B Subfamily

CYP7B1      human
            GenEMBL AF029403
            Setchell,K.D.R., Schwarz,M., O'Connell,N.C., Lund,E.G., Davis,D.L.,
            Lathe,R., Thompson,H.R., Weslie Tyson,R., Sokol,R.J. and
            Russell,D.W.
            Identification of a new inborn error in bile acid synthesis:
            mutation of the oxysterol 7alpha-hydroxylase gene causes severe
            neonatal liver disease.
            J. Clin. Invest. 102, 1690-1703 (1998)

CYP7B1      Pan troglodytes (chimpanzee)
            XM_001159731.1
            99% (3 aa diffs) to human
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPG                      EPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLV                      IKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN                      LKQVFEPQLLKTTSWDMAQLYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLK                      FDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYV                      HEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKG                      SGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDL                      VAIFPPILHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCP                      GRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRYKVKS

CYP7B1      Bos taurus (cow)
            See cattle page for details
MNAGMGGFWPEPWLTRSLGYPGLALAAALLLLVLCLNARRTR (2)
RPGEPPLIKGWLPYFGQALKLQKDPLGFMTSLQKQYGDIFTLLLG (1)
GKYITFILDPFHYTSVAKNQKLSFQIFTNKFLKRVFSIKKMLTDSDLIDEIHSTYQ 56
  3 FLQGKHLDILMESTMQNLKQVFEPQLLKTTSWSTEYLLPFCNSVIFEMTFTTIYGNILAD 182
183 DKKTFITELKDDFLKFDEKFTRLASGIPIELLGNIKSVRTKLIKDLTIESLAKLQGMSEV 362
363 VQRRNDILEKYYTPKDTEIG (1)
AHHLGLLWASVTNTVPTMFWAMYYLLRNPKAMAVLRDEIDHLLQSTGQKKGPGFSIYLTR
EQLDSLVYL (1)
ESTILEVLRLCSFSGIFRFVQEDLTLHLESQDCCLRKGDFVVIFPPILHHDPEIFEAPD
EFRFDRFTENGKKKTTFFKRGKKLKYYHLPFGLGVSKCP
GRFLAMVEIKQLLVVLLTYFDLEIIDNKPLELNYSRFLFGIPYPDSDVLFRYKIKS

CYP7B1      pig 
            AJ956520.1, AJ955923, CK455462.1, CJ000103.1 
MGRFSPEPWLPQLLSPRGLALAAALLLLVLFLRTRRTRRPGEPPLVKSWLPFIGEAL
KLQRDPIGFMTTLQKQYGDIFTVLLGGKYITFILDPFQYQSVIKNQKLSFRGFSNKVLL
RVFSIKKLVEDDAMNDELHTCYQLLQGRHLDMLMENTMQSLKQVFEPQLLKTTSWHTESL
FTFCNSVIFEMTLTTVYGSILLGHRKTFITELKDDFFKFDGKFTQLASGMPIELLGNIKSIRLKLIKL
LTTENLAKFQGWSEVVQRRQDILEKYYLPQDIEIGAHHLGLLWASVANTAPTMSWTMYYL
LRNPEAMAVLRDEIDHLLQSTGQKKGPGFSIHLTREQLDSLVYLESTILESLRLSSFSST
FRFVQEDLTLHLEAQDCCLRKGDFVGVFPPILHYDPEIFEAPEEFRFDRFVENGKKKTTF
FKRGKKLKYYLMPFGFGISKCPG
RFLAVVEIKQLLVILLTYFDLEIIDDKPVKLNFSRSLFGIQHPDSDVSFRYKVKS*

CYP7B1      Canis familaris (dog)
            XM_544102.2
MNGHTSGSLQFSTVPSAWRTLGVLESEWTKKGESAAKRQKVTEL
QVRCEYNVNGDRAEMSAPPPSGGSTWAAIQWMGPSSTKEERGCDEQISPRRPGEPPLI
KGWLPYLGEALKLQKDPLGFLRTLQKQHGDTFTLFAGGKYITFILDPFQYQLIMKTHK
LSFRIFSNKLSRKVFSIKKLETTDDLSNDLHGCYHLLQGKSLDVLTETMMQNLKQVFE
LHLLKTTNWDMAHLLTFCSSIIFEITLKTIYGKSLAGNGEKFITELRDNFLKFDDKFP
YLISDIPIELLGNIKSIRKKLIKHLASEHLGKTQGWSEIVQMRQDVLEKYYTLEDFEV
GAHHLGFLWASVTNTIPTMFWAMYYLLQHPEAMAVLRDEIDHLLQSTGQKKGSGFPMH
LTREQLDNLVYLESTVLEVLRIRSFSSIIRFVQEDLTLHSETQDYCLRKGDLVALFPP
AIHYDPEIFEAPEEFRFDRFVEDGKKKTTFFKKGKRLKYYLLPFGIGTSKCPGRFLAV
VEIKQLLVVLLTYFDLELIDDKPVVANRSRLLLGVQHPASDVFFRYKVKT

CYP7B1      rat
            GenEMBL U36992 (1763bp)
            Stapleton,G., Steel,M., Richardson,M., Mason,J.O., Rose,K.A.,
            Morris,R.G.M. and Lathe,R.
            A novel cytochrome P450 expressed primarily in brain.
            J. Biol. Chem. 270, 29739-29745 (1995)

Cyp7b1      mouse
            GenEMBL U36993 (1880bp)
            Stapleton,G., Steel,M., Richardson,M., Mason,J.O., Rose,K.A.,
            Morris,R.G.M. and Lathe,R.
            A novel cytochrome P450 expressed primarily in brain.
            J. Biol. Chem. 270, 29739-29745 (1995)
            39% identical to CYP7A subfamily

            Ken A. Rose, Genevieve Stapleton, Karin Dott, Marie Paule Kieny, Ruth 
            Best, Margrit Schwarz, David W. Russell, Ingemar Bjšrkhem, Jonathan 
            Seckl, and Richard Lathe 
            Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of 
            neurosteroids 7-
            alpha hydroxy dehydroepiandrosterone and 7-alpha hydroxy pregnenolone 
            Proc. Natl. Acad. Sci. USA  94, 4925-4930 (1997)
MQGATTLDAASPGPLALLGLLFAATLLLSALFLLTRRTRRPREP
PLIKGWLPYLGMALKFFKDPLTFLKTLQRQHGDTFTVFLVGKYITFVLNPFQYQYVTK
NPKQLSFQKFSSRLSAKAFSVKKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQEVK
ELFESQLLKITDWNTERIFAFCGSLVFEITFATLYGKILAGNKKQIISELRDDFFKFD
DMFPYLVSDIPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQESQDLLKRYYRHD
DSEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPG
ISVHFTREQLDSLVCLESTILEVLRLCSYSSIIREVQEDMNLSLESKSFSLRKGDFVA
LFPPLIHNDPEIFDAPKEFRFDRFIEDGKKKSTFFKGGKRLKTYVMPFGLGTSKCPGR
YFAVNEMKLLLIELLTYFDLEIIDRKPIGLNHSRMFLGIQHPDSAVSFRYKAKSWRS

CYP7B1      Monodelphis domestica (gray short-tailed opossum)
            DQ037866
RPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQL
VIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNL
KQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDD
KFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLE
IGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHL
TREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLH
GDPEIFEAPE

CYP7B1      Gallus gallus (chicken)
            AY700579
            Christoph Handschin
            Submitted to nomenclature committee 3/27/02
            54% to human 7B1
PWRRSAGGAAAAALLLWVVCVLCRRKRKTGEPPLINGWIPYLGK
ALPFRKDAFKFLLDQQKKLGDIFTVHIAGRYITFIMDPFQYVYVIRNSKQLEFHEFAD
KMASKTFDYPALSNVKFPDLKENLHRIYQYLQGKPLEIISDHMMKNLQDIFEWKCSQA
TDWETEKMYKFCCSVMFEASFVTLYGRVPAADGRKVISEIRDKFIKFDASFPYLAANI
PIELLGATKKVRKELIHHFLLQNMTKWLGGSKVVQARQDIFEKYELLGDYDKAAHHFA
FLWASVGNTIPATFWAMYYLLRHPEALAAVRDEITHLLQSTGQKRGPTYNIHLTREQL
DNLVYLESALNESLRMCSSSMNIRISQEDFVLKLEGDQEVSLRKGDWIALYPQILHMD
PEVYEDPKKYKFDRYIENGKKKTTFYKAGRKLKYFLMPFGSGISMCPGRFLAMNEMKM
FLFLLLAHFDVELGENKAVRLDNSRM

CYP7B1      Xenopus tropicalis (Western clawed frog)
            CX908537.1 CX805060.1 CX814354.1 BX713865.1 CN080250.1
            52% to 7B1 human
MLDTLLYTVTGLVLGGLLLLLLLPRRQ
RREGEPPLENGWIPFIGLAYEFHKNALEFLISRQQKYGDIFTVHVAGKYITFIMDSTQFQ
YVIKHGKQLDFHEFANSLSSRTFDHPRLTEAKFPHLNDKLHRIYKIMQGRALDKLTDSMM
GNLQRVFKWKFSQATDWKAEKMYQFCCCIMFEASFMTLYGRDPIADGHKVISEIREK
FTKFDAKFPYLVINIPIALLGATKKIREELIHFFFPNKMEKRSEISEVVQERKNVLEQYE
LQDYDRAAHHFAFLWASVGNTIPATFWAMYYLVRHPEALAAVRDEIDHLLQSTGQKKGP
EYDIHITREQLDSMVLLGSAIKESFRLCAASMNIRLVQEDFDLELEGNQTIRLRKDDFIA
LYPPALHMDPEIYEDPERYKYDRFVENGKEKILFYKKGKKLKEYLMPFGSGTSKCPGRFF
AMNEIKQFLAVLLIYVEMELVEHKALGHDNRRSGLGILLPNSDIMFRFKPRTLDL*

CYP7C1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_16085
            N-terminal revised June 18, 2010
     MSGLLLLLVGVLSLLVCVLRRRIR (2)
     RDNEPPLVIGWIPFVGKAVEFGRDAQGFLLQQKKKFGDVFTVLIA (1)
1129 GKYMTFIMDPLMYPNIIKHGRQLDFHSFSDSMAPVVFGYPPVRSWKTPSLHEDIQ 1293
1294 RAFKLLQGDHLCALTEGMMGNLMMLLRQDHLGRRPGAGPGWKSGDMYEFCSRVMFEATFL 1473
1474 TLYGIPQEGGRHDGMDELRKDLFQFDGWFPWLVAGVPIGLLRQAKTSRNKLTRS 1635
1636 LLPMRISSWSNRSQFIRRRQELVEKVDALKDVDRA 1740 (1)
2208 AHHFAMLWASVANTIPACFWSMYNLVSHPDALQVVRQQILDELKLSGVQFSTDTDVTL 2387
2388 SRDLLDKLLYL (1) 
     ESSVNESLRLSSASMNIRVAQEDFSLHLKNERSANVRKGDIIVLYPQSLHMDPEVYEDPQ 2666 (0)
2786 TFQFDRYVQDSKGGFFKGGQRLKYYLMPFGSGSSMCPGRHFAVNEIKQFLCLMLLYF 2956
2957 NLELEPGQTRATVDSSRAGLGILFPSAKVHFRYRLRCV* 3073

CYP7C1     Fugu rubripes (pufferfish)
           ENSTRUT00000025007
           next to ARMC1
           length=498 (last 6 aa do not agree with sequence from Scaffold_16085
MSGLLLLLVGVLSLLVCVLRRRIRRDNEPPLVIGWIPFVGKAVEFGRDAQ
GFLLQQKKKFGDVFTVLIAGKYMTFIMDPLMYPNIIKHGRQLDFHSFSDS
MAPVVFGYPPVRSWKTPSLHEDIQRAFKLLQGDHLCALTEGMMGNLMMLL
RQDHLGRRPGAGPGWKSGDMYEFCSRVMFEATFLTLYGIPQEGGRHDGMD
ELRKDLFQFDGWFPWLVAGVPIGLLRQAKTSRNKLTRSLLPMRISSWSNR
SQFIRRRQELVEKVDALKDVDRAAHHFAMLWASVANTIPACFWSMYNLVS
HPDLQVVRQQILDELKLSGVQFSTDTDVTLSRDLLDKLLYLESSVNESLR
LSSASMNIRVAQEDFSLHLKNERSANVRKGDIIVLYPQSLHMDPEVYEDP
QTFQFDRYVQDSKGGFFKGGQRLKYYLMPFGSGSSMCPGRHFAVNEIKQF
LCLMLLYFNLELEPGQTRATVDSSRAGLGILFPSAKVHFRYRWSSWSS

CYP7C1    Tetraodon nigroviridis (freshwater puffer)
          84% TO FUGU CYP7C1
MSGLLLLFFGVLSLFICFLRRRTR (2)
RVNEPPLDIGWIPYIGKAVEFGKDAHGFLLQQKKKFGDVFTILIA (1)
GKYMTFIMDPLMYPNIIKHGRQLDFHSFSDTMAPLVFGYPPVRSYRSPSLHEDIQR 
AFKLLQGDHLCALTESMMGNLMMLLRQQHLGLKPKVGSGWKTDDMYEFCSRIMFEATFN 
TLYGTPQDGGRHGAVEKLRRELFQFDSWFPLLVAGIPIGLLRQAKTSRNKLLKNLLPNR 
ISSWSNRSQFISRRQELVEKVDVLTDMDRA (1)
AHHFAMLWASVANTIPACFWSMYNLVSHPDALRVVRQQIFDVLKLSGVEFSVDKDVTLSKDFLDKLLYL (1)
ESAINESLRLSSASMNIRVAQEDFSLHLKNERSVKVRKDDIIVLYPQSLHMDPEVYEDPQ (0)
MFQFDRYIQDNSGKSVFFKDGQKLKYYLMPFGSGSSMCPGRHFAINEIK
QFLCLMLLYFDLELDLGQTRATVDSSRAGLGILFPSTNVRFRYRLQ*

CYP7C1    Danio rerio (zebrafish)
          See zebrafish pages for seq

CYP7C1     Gasterosteus aculeatus (stickleback)
           next to ARMC1 in Stickleback
           43% to CYP7B1 human, 42% to CYP7A1 human
           56% to CYP7C1 zebrafish, 41% to CYP7A1 zebrafish, 
           40% to CYP7D1 zebrafish
           60% to CYP7C1 fugu, 39% to CYP7A1 fugu
(seq gap)
VTFGYPPIRGGKFPGLPEQIGRTFQLLQGDGLSALTESMMSNLLLLFRQDHLGGPPPGGA 3355
SGDWRSAGMYEFCNSIMFEATFLTIYGRPASASRHSDTGLLRRDFVRFDNMFPLLIAQIP 3175
IRLLGRTKAVRDKLIDYFLPHRMSRWADTSLFIRTRSELFEQYDALGDVDKA (1) 3019
AQHFAILWASVGNTIPATFWAMYHLARHPEALREARREIQSVLGLGDGVPFSSSRDVRLD 992
REQLEKLVYL (1) 962
ESAISESLRLSSASMNIRVAQEDFSLRLDAGRSVAVRRGDFVALYPQTMHMDPEIYEEPQ (0) 708
SFRADRFLQDGVEKTDFYKDGQRLRYYLMPFGSGSSRCPGRFFAVNEIKQFLCVLLLCV 374
DLQLEDGQAGATLDASRAGLGILLPAADVRFRYRPRNM*

CYP7D1    Danio rerio (zebrafish)
          BG883457 fp29f09.x1 381-502 
          54% to 7A Z35725-a6349d05.p1c
          N-term revised June 18, 2010
MSTFLFTVAAILLTLFIVWICGHTRKR (2)
KPGEPPLVTGWLPFIGVTKDYVSNPLGFLTETQKKHGNVFTCLIA
GKYFTFVTDPFSFSSVVRQGKNLDFQKFAINFSQR (0)
VFGHADFNSPQLSGNYREIHSIFRQTLQGPSLQHLTQSMLCNLQTVLERCLPHEHDWLEEGVQSFTNR
IMFEAGFLTLFGKEDIRFLQDHGMSGNRISMPKATQDFLVFDHAFPLLAAGVPIGLCTKAWRARE
ALAEELLHDELHRRKCISDLIQRRMDIFDRMLLDETGKARTDVCMLWASQANTLPAAFWSLYYTLK (2)
SVDAFTAARTEVNRVLLGQSLNNKDQTVYLSKDQLDSMTVL (1)
ESIIEEALRLSSASMMIRVASDDFTLTLESDQTAAIRKGDYIALYPQLLHLDPEIYPNPT (0)
EFKYNRFLDENDQPKTNFFKSGRRLRNFLMPFGSGASECPGR
FFAVYEIKLFLALTLWHYDLQLRDPDVPVVQDSARAGLGIMPPSQDVLLRFRKKQRTPGNEHKDTK*

CYP7D1    Ictalurus punctatus (channel catfish)
          GenEMBL CB936535.1
          73% to Danio 7D1

CYP7D1    Pimephales promelas
          GenEMBL DT118939.1 
          73% to Danio 7D1

CYP7      Eptatretus burgeri (hagfish)
          GenEMBL BJ652936.1 BJ664927.1 ESTs C-term
          49% to human CYP7B1, 47% to human 7A1, 55% to Xenopus 7B1, 
          44% to xenopus 7A1
2    SARGLPAAFWALYHLLCHPDALTVIRKEVDDVLKSTGQYPKPSSLLKLSPTTLPNLVCLG  181
182  SAISESLRLCSASINIRVAQDDLDLELEPGRTVPLRKNDWVAMYPQTALHLDPEIYPEPE  361
362  IYKYDRFLENGQEKTNFYKGGQKLHHYLMPFGSGVSMCPGRFLALNEIKQFLFLLIAVL  538
539  DLEILPDQPQVKIDNGR  589

CYP7    Branchiostoma floridae (lancelet) 
MVTELLGVCLAVVLVFVLLQVTTRR (2)
RRPGEPPLEPGPLPYLGVALEFSRNPLGFITSRWKKYGDVFTVRLAGHYTTFVLDPHSFTHAIRNSK (2)
VLDFRVFSSKIAHRAFGMPIVYGTHRDWVRADSDALYPKELQGQGLEKVTE (0)
VMMNNLQSAMLAATDVKDKWNKGELWSFVYRIMFS (1)
ASYKTLFGRHKEDEEETARLLHAMEEFQKYDKRFPEIISNVPWWLMGQTKKRYEYLK (0)
SMVSPTELSQRGVSDFIRMRQEIYADGNLSPDEMTGFNFATMWASL (0)
SNTVPAAFWTLFYLLKDPVAMDAVREEVNQ (0)
ILKETGQSLETVKEAGEMLHVTREQLNDMKCL (1)
GSAINEALRMCSASIIIRVATEDAELALESGSTFRIRKGDRVALYPGFLHMDPEVFDDPE (0)
TFKYDRFLENGMEKTTFYKNGRKLRHYLLPFGHGASMCPGRFFALNEIKQFVTIVVCYFN
MELMEKQTPPKDQSRAGLGTLAPLKECLFRYSLK*

CYP7-like    Ciona savignyi 
             one intron shared with human CYP7A1 ortholog 
             seq 166 
MLVSIIYTVLLLLLSSYAIWFIAKRKQKRGEPPIVPFWIPWL (1)
GSGLTYQKDPIAFLKKQTKKYGPIFTVFM (1) 
GGNYFTFVTDPFTHPLVAKEGKILNFRICTLPMIKHLFDYQRPAVEEPTMGGLFVKYLQ (0)
GQRLNVMIEKMMKCLQRIMLAGKYTNTDWSEVGLLHFVESIMCTASFSTL (2)
FGDYPKSSNKDIPAFEHQMFEDFRKFDEAFPYLVKGYPLNSFK (0)
GLEESRKNFWKHLASDELNKREMVSDLIAEYARICDAEKDRTLPKKLFSTAWAAQ (0) 
SNTMVSAFWTIYFVTKHGDAKAAAEVEIQRLLKETSQTLDGKTPINFNRDDMDKMTVL (1)
DSIINESLRLHVSASMLRQALQDYDLKVLSVGKTYRLRKGDRVMSLFELNHKDPEIYS
NPEVFKYDRFLNEDGSLKTDFYKNGKVVRFALQPFGSGL (2)
SKCPGRYWAVTELKQIVILLLLYFDFELINPNEEIKMNKNRVAFGSLPPTNDPKIRFPSTV*

8A Subfamily

CYP8A1      human
            GenEMBL D83402
MAWAALLGLLVALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYAL
DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIF
LMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH
EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLA
RGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARA
LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV
LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ
RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS
IKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

CYP8A1     Pan troglodytes (chimpanzee)
           XM_514713.3
           PTGIS prostacyclin synthase
           98% to human, except at the N-term
           chimp N-term may be in a seq gap and this N-term may 
           be a prediction error
MPAASQSRSRDGLGALLGLWRTVAAAATEPRRTR
RPGEPPLDLG                      
SIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYITVLLDPHSYDAVVWEPRTR                      LDFHAYAIFLMERIFDVQLPHYSPSDEKARMKPTLLHRELQALTEAMYTNLHTVLLGD                      ATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQ                      LDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMG                      VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVS                      QTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRL                      LLFPFLSPQRDPEIYADPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHC                      LGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR P

CYP8A1      bovine
            GenEMBL D30718 (2206bp)
            Hara,S., Miyata,A., Yokoyama,C., Inoue,H., Brugger,R.,
            Lottspeich,F., Ullrich,V. and Tanabe,T.
            Isolation and molecular cloning of prostacyclin synthase from bovine 
            endothilal cells.
            J. Biol. Chem. 269, 19897-19903 (1994)

CYP8A1      bovine
            GenEMBL L34208 (1920bp)
            Pereira,B., Wu,K.K. and Wang,L.-H.
            Molecular cloning and characterization of bovine prostacylin
            synthase.
            Biochem. Biophys. Res. Commun. 203, 59-66 (1994)

CYP8A1      bovine
            GenEMBL S67757 (676bp)
            Pereira,B., Wu,K.K. and Wang,L.-H.
            Bovine prostacyclin synthase: purification and isolation of partial 
            cDNA.
            Biochem. Biophys. Res. Commun. 197, 1041-1048 (1993)

CYP8A1      Bos taurus (cow)
            See cattle page for details
30 MSWAVVFGLLAALLLLLLLTRRRTRRPGEPPLDLGSIPWLGHALEFGKDAAGFLTRMKEK 209
 210 HGDIFTVLVGGRHVTVLLDPHSYDAVVWEPRSRLDFHAYAVFLMERIFDVQLPHYNPGDE 389
 390 KSKMKPTLLHKELQALTDAMYTNLRTVLLGDTVEAGSGWHEMGLLEFSYGFLLRAGYLTQ 569
 570 YGVEAPPHTQESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDRVGKVKGRLWKL 749
 750 LSPTRLASRAHRSRWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 929
 930 KNPEALAAVRGELETVLLGAEQPISQMTTLPQKVLDSMPVLDSVLSESLRLTAAPFITRE 1109
1110 VVADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPEVFKYNRFLNPDGSEKKDF 1289
1290 YKDGKRLKNYSLPWGAGHNQCLGKGYAVNSIKQFVFLVLTQFDLELITPDVDIPEFDLSR 1469
1470 YGFGLMQPEHDVPVRYRIRP* 1532

CYP8A1      human
            GenEMBL D38145 (1977bp) PIR JC2231(500 amino acids)
            Miyata,A., Hara,S., Yokoyama,C., Inoue,H., Ullrich,V. and
            Tanabe,T.
            Molecular cloning and expression of human prostacyclin synthase.
            Biochem Biophys.Res. Commun. 200, 1728-1734 (1994)

CYP8A1    Sus scrofa (miniature pig) 
          no accession number
          Haitao Shang
          Submitted to nomenclature committee May 23, 2007
          partial sequence
          90% to human 8A1, full seq. is not known
          Ortholog of human CYP8A1

CYP8A1    Sus scrofa (pig)
          Pig ESTs BP457025.1, BE013722.1, BE013644.1, AJ666831.1 
          lower case = cow seq
mswavvfgllaallllllltrrrtrrpgeppldlgsipwlghalefgkdaagfltrmkek 
hgdiftvlvggrhvtvlldphsydavvweprsrldfhayavflmerifdvqlphynpgde 
kskmkptllhkelqaltdamytnlrtvllgdtveagsgwhemgllefsygfllragyltq 
ygveapphtqesqaqdrvhsadvfhtfrqldlllpklargslsagdkdrvgkvkgrlwkl 
lsptrlasrahrsrw 
LESYLQHLEEMGVSEQMQARALVLQLW
ATQGNMGPAAFWLLLFLLKNPEALAAVRGELEPILSRAEQPISQMTTLPQKVLDSTPVLD 
SVLSESLRLTAAPFITREVVADLALPMADGREFTLRRGDRLLLFPFLSPQKDPAIYTDPE 
VFKYNRFLNPDGSEKRDFYKDGKRLKNYSLPWGAGHNQCLGRAYAVSSIKQFVFLVL 
AHFDLELSSPDVEMPEFDLSRYGFGLMQPERDVSIRYRLRA*

CYP8A1      Canis familaris (dog)
            XM_543043.2
MVTCFSFTVAGKGVRNRRVLMGAASGVLSGGETGQVVKLAMESE
SEEWALWGGTHMLGIKAPGEDQKRRPGEPPLDLGSIPWLGHALEFGKDAASFLTRMKK
KHGDIFTVLVGGRYVTVLLDPHSYDAVVWEPHSKLDFHAYAVFLMERIFDVQLPHYSP
SDEKAKMKPTLLHKDLQALTDSMYANLRTVLLGDTTEAGSGWHEISLLDFSYSCLLRA
GYLTLYGVEALPRTHESQAQDRAHSADVFHTFRQLDLLLPKLARGSLSAGDKDQACRV
KGRLWKLLSPARLATRAHRSNWLESYLLYLEEMGVSADMQARALVLQLWATQGNMGPA
AFWLLIFLLKNPEALAAVRGEFEQLLSRAEQPISQMTTLPQKLLDNMPVLDSVLSESL
RLTAAPFITREVMVDLAMPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPEVFKYN
RFLNSDGSEKKDFYKDGKRLKNYSMPWGAGHNQCLGKAYAISSIKQFVFLVLVHLDLE
LINPDMEIPEFDLSRYGFGLMQPEHDVPVRYRTRP

CYP8A1      rat
            GenEMBL U53855(1618bp)
            Geraci,M.W., Gao,B., Shepherd,D., Moore,M., Vernon,J., Miller,Y.E.
            and Voelkel,N.F.
            Nucleic acid sequence of rat prostacyclin synthase
            unpublished (1996)

Cyp8a1      mouse
            GenEMBL AB001607 AA032426, AA000011, W76862, W13004, W64189
            overlapping EST fragments that match best to CYP8A1
MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHA
LEFGRDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWELRTRLDFHPYAI
FLMERIFDLQLPNFNPSEEKARMKPTLMHRDLQALTEAMYTNLRTVLLGDSTEAGSGW
QETGLLEFSYNALLSAGYLTLYGVEASPRTHESQAQDRVHSADVFHTFRQLDLLLPKL
ARGSLSAGDKDHACSVKNRLWKLLSPARLASRADRSSWLESYLRHLEEMGVSEEMQAR
ALVLQLWATQGNMGPTAFWLLLFLLKNPEALAAVRAELKHTVWQAEQPVSQMTTLPQK
ILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADGREFSLRRGDRLLLFPFLSP
QKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAIN
SIKQFVVLLLTHFDLELGSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRARL

CYP8A1      Xenopus tropicalis (Western clawed frog)
            DT406915.1 DN063760.1 cannot extend in ESTdb
            29605_prot model missing internal exon(s) UCSC browser
            55% to 8A1 human
MVWAGVFSLLLLILCIGFCYYRFLHRTR (2)
QPNEPPLDRGSIPWLGYALEFGKDAAKFLSDMKEKHGDIFT (0)
IQVAGKFITVLLDPHSYDAVFWAPSNQLDFGKYARMLMDRMFDVRLPPSGGNEEKTLLAS (2)
HFQGSNLTKLTRSMFHNLSTILLKDRRLPNTEWTDQGLFDFIYGVMLR (2)
AGYLTLFGTESEQYTSTYSPMRDLKHSEDVYKEFRKLDWLLMKAARNTLST (1)
GEKEEASLVKNRLQKLISIKSHKGKCCKSSWFEYYQQHLEEIQATEDMQSRALVLQLWATQ (0)
GNAGPATFWLVLYLLKHPEAMAAVQAEFESIFQRNLQEKRHIEEMNQDLLDKMIIL (1)
DNVLNETLRLTAAPFISREVLTDMTLKLADGHQYQLRRGDRLCLFPFVSPQMDPEVHQQPE (0)
VFQHNRFLNADGTEKTEFYKKGKRLKYYNLPWGAGSNVCVGKKHAVNSIKQ (2)
FVCLLLFYFDFELKTPAEKIPEFNRTRYGFGLLQPEHDILFRYRRKA*

CYP8A1    Danio rerio (zebrafish)
          See zebrafish pages for seq

CYP8A1      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_4451
            55% to 8A1 human over 423 aa
      MIWTVLLLVHALLLYFILRHRSR 15761 (2)
      NEPPLDKGLIPWLGHALEFGKDASKFLERMKRKHGDIFT 15636 (0) 
      VRAAGRYVTVLLDPHSYDQVIHDQDCLDFHSYAKVLMERIFQLRLPNHEPAKEKAVMTQ (2)
15682 HFLGMNLCGLNSSMSRHMLEVAKAEMPQNQKDWKEDGLFNLSYSLLFK 15539
      VGYLTLFGGEQNNNCSDLASIYEEYKKFDGLLTKMARGTLKS (1)
      YEKKTAQSARQRLWELLAPARLAKGSGSTPWLHAYRRLLREEGVDNEMQTRALLLQLWATQ (0)
      GNVGPAAFWMLGYLLTHPEALTAVKTEMEALQLSPLDSSVVTPVF (1)
      DSALDEALRLTAAPFITREVLQDKVLHMADGQQYLLRKGDRVCLFPFISPQMDPEIHQEPQ (0)
12256 KYKFNRFLNEDGSVKKDFYKGGRRLKYYSMPWGAGANGCVGKQFAISTMKQ 12107 (2)
      YIYVLLTNYDLELCDPCALMPGVNASRYGFGMLQPEGDLLVRYRPRQKL*

CYP8A1   Tetraodon nigroviridis (freshwater puffer)
         54% to CYP8A1 zebrafish, 80% to CYP8A1 fugu
MI & WAVLLLVHLLLLYFVVTRRSR (2)
SKNDPPLDKGLIPWLGHALEFGQDAAKFLSRMKRKHGDIFTVRAAGRYVTVLLDPHSY DPVIHNQDSLDFHRYAQVLMERIFLLQLPNYQPDKEKAVMKQ (2)
HFLGKNLSALNSTVSKHMHNLLKTEMPQNQKDWKEDGLFNLSYSLLFK (2)
VGYLTLFAGEQSSDSSHLAVVYEEFKKFDGLLTKLARGTLKS (1)
ADEKKTAQSVRQRLWRLLAPAALTGGLGSTPWLDGYRQVLKEEGADDEMQARALLLQLWATQ (0)
GNVGPAAFWLLGYLLTNPEALAAVKTEMEALRLPPLDSSVSTPVL (1)
DSALDETLRLTAAPFITREVLQDTPLHMADGQQFVLRKGDRLCLFPLISPQMDPEIYQEPQ (0)
KYKFNRFLNEDGSVKKDFYKGGKRLKYYNMPWGAGLNGCMGKEVAITTLKQ (2)
FTYMILTQYDLELCNPRAQIPAVDVSRYGYGMVQPEGDLLVRYKPKKTF

CYP8A2      Fugu rubripes (pufferfish)
            No accession number
            Scaffold_5061
            48% to 8A1 human over 491 aa
      MIWAALLGGLLTLVLLYFSRRR (2)
15028 QDNEPPLDKGALPWLGHALEFGRDAAKFLARMKEKHGDVFT 14906 (0)
14562 VRVAGQYITVLLDANSFDSVLNDTVSLDFVKSKNQLLERIFFLKLPGLQPAAEREWMEQ 14389 (2)
14306 HFHGFRLSNLSGTMKANIESLLLSDVKGGSASGWRQDGLFNFCYSLLFR 14163 (2) 
      AGYLTLFDSADNVTAIYKEFRKFDKLLSKLVRGSLKK (1)
      GETHTVNSSRKRLWELLSADWLSRASGSISWQQSYNRFLEKEGVDMEMQRRASLLQLWTTQ 13707 (0)
      CNNGPAAFWLLGFLLTHPEAMEALKSEIRQFNLQDPAVRHRTSGSPDSRRTPVF 12379 (1)
12150 DSILSETLRLTAAVLISRVVVGDKVLRMASGQQYKLRRGDKAILFPFLSPQMDP 11989 (frameshift)
      EIHLEPQ (0)
11610 SFKYDRFLNIDMSMKDTFYKNEGRLKYYTMPWGAGRHACVGKEFAVATIKQ 11458 (2)
10998 FVFFILTHFDLETCDPQAKLPPVNPSRYGLGMLQPEGELQVRYRLKRSQPET* 10840 

CYP8A2   Tetraodon nigroviridis (freshwater puffer)
         chr11 4876258-4880369 (+) strand
         ortholog to CYP8A2 fugu, 79% to CYP8A2 fugu, 
MIWAALLGITGILTLVLLFFSRTR (2)
QENEPPLDKGALPWLGHALEFGRDAAKFLARMKEKHGDVFT (0)
VRVAGQYVTVVLDANSFDSVVNDTVSLDFISSKNQLLERIFHLKLPGLQPAAEREWMER (2)
YFQGCRFAKLCQTMKANIESLLLGEVQGSSASEWKQDSLFSFCYSLLFR (2)
AGYLTMFESTGNANVVYEEFRKFDQLLPKLAQGSLKK (1)
EESQTVNSSRERLWKLGSADWLSQGSGPLSWQQSYLRFLHEEGVGAEMQKRASLLQLWTTQ (0)
CNNGPAVFWLLAFLLTHPEAMEALKSEIRRLNLQDPSGHHLTSNSLELYHTPVF (1)
DSILSETLRLTAAVLIKRVVVEDKVLQMASGQRYKLRRGDKVILFPWLSPQMDPEIHPEPQ (0)
SFKFDRFLNNDRSVKDKFYKNERRLKYYTMPWGAGRHACIGKEFAIATIKQ (2)
FVFFILTHFDVKKLEPQAQLPPVNPSRYGFGMLQPDGDLQVQYRLKRSQSET*

CYP8A3P     Fugu rubripes (pufferfish)
            Scaffold_11168   Length = 7738 60% to CYP8A2
347 (2) RDNEPPLVMGWIPFVGKAVEFGRDAQGFLLQQKKKFGDVFT 225 (0


8B Subfamily

CYP8B1     rabbit
           GenEMBL Y08269
           Eggersten, O., Olin, M., Andersson, U., Ishida, H., Kubota, S., 
           Hellman, U., Okuda, K.-I. and Bjorkhem, I.
           Molecular cloning and expression of rabbit sterol 12 alpha-hydroxylase.
           J. Biol. Chem. 271, 32269-32275 (1996)
           erroneously called CYP12 in this paper.  CYP12 is an insect sequence.

CYP8B1     human
           GenEMBL AF090318
           Gafvels,M., Olin,M., Chowdhary,B., Raudsepp,T., Andersson,U.,
           Persson,B., Jansson,M., Bjorkhem,I. and Eggertsen,G.
           Structure and chromosomal assignment of the sterol
           12-alpha-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic
           cytochrome P-450 gene devoid of introns.
           Genomics 56, 184-196 (1999)

CYP8B1     Pan troglodytes (chimpanzee)
           XM_001140682.2
           98% to human CYP8B1
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLG                      HAMAFRKNMFEFLKRMRTKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQY                      AKKLVLKVFGYRSVQGDHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGSSLD                      ASCWHEDSLFRFCYYILFTAGYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVY                      SLLWPREWLEVGRLQRLFHKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFN                      FMMLWASQGNTGPTSFWALLFLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGAL                      QHTPVLDSEVEETLRLKAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHM                      DPDIHPEPTVFKYDRFLNPNGSRKVDFFKAGKKIHHYTMPWGSGVSICPGRFFALSEV                      KLFILLMVTHFDLELVDPDTPLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE

CYP8B1     Macaca mulatta (rhesus monkey)
           AC198108.4
           96% to human 8B1
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPREPPLDKGTVPWLGYAMAFRKNMFEFLK
RMRSKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQG
DHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLKSKGWSLDASCWHEDSLFHFCYYILF
TAGYLSLFGYTKDKEQDLLQAGELFVEFRKFDLLFPRFVYSLLWPQEWLEVGRLQRLFHK
MLSVSHSQEKEGISNWLCNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLFL
LKHPEAIRAVRQETTQVLGEARLETKQSFAFKLSALQHTPVLDSVVEETLRLRAAPTLLR
LVHEDYTLKMASGQEYLFRRGDILALFPYLSVHVDPDIHPEPTIFKYDRFLNPNGSRKVD
FFKAGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQ
RWGFGTMQPSHDVRFRYRLRPIV*

CYP8B1     Sus scrofa (pig)
           AJ488932, NM_214426
           Lundell,K. and Wikvall,K.
           Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and
           expression in fetal liver: comparison with expression of
           taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)
           Biochim. Biophys. Acta 1634 (3), 86-96 (2003)           
           Submitted to nomenclature committee August 26, 2002
           81% to CYP8B1 human
MVLWGPVLGVLLVAIVGYLCLQGLLRQRRPEEPPLDKGSVPWLG
HAMTFRKNMLEFLKHMWARHGDIFTVQLGGQYFTFVMDPLSFGPILKDAKRKLDFVEY
AEKLVLKVFGYRSMQGDHRMIHSASTKHLMGDGLEELNKAMLDNLSLVMLGPKGPSPD
ASCWREDGLFHFCYDILFKAGYLSLFGRTEDKEQDLLQAEELFMQFRKFDRMFPRFVY
SLLGPREWLEVGRLQCLFHKMLSVEHSLERHGISSWITDMLQVLREQGVAPAMQDKFN
FMMLWASQGNTGPTTFWALLFLLKHPEAMRAVREEATRVLGEARLEDKQSFDVEVSAL
NHMPVLDSVMEETLRLGAAPTLLRVVNSDQILKMASGQEYRLRHGDILALFPYLSVHM
DPDIHPEPTTFKYDRFLTPSGSRKVNFYKAGKKIHHYTMPWGSGISICPGRFFALTEM
KLFVLLMVTHFDLELVDPDTPVPPVDPQRWGFGTMQPSYEVRFRYRLRPTE

CYP8B1      Bos taurus (cow)
            See cattle page for details
MVLWGPALGALLVAIVGYLCLRGLLRQRRPKEPPLDKGPVPWLGHAMAFRKNMFEFLRHM 
QAKHGDIFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVEYAQKLVLKVFGYRSVQGDY 
RMIHSASTKHLMGEGLEELNKVMLDTLSLVMLGPIGPSLGTHHWREDGLFHFCYNILFKA 
GYLSLFGYTKDKEQDLLQAEELFLEFRKYDRLFPRFVYSLLGPREWLEVGRLQRLFHKEL   
SVEHNLEKYGVSNWITYMLQFLREQGVSPAMQDKFNFMMLWASQGNTGPTSFWALLFLLK 
HPEAMRAVREEATRLLGEVRLEAKQSFKFGALHHMPVLDSVMEETLRLRASPTLLRVV 
NDDQILQMASGQEYMLRNGDILALFPYLSVHMDPDIXXXXXXXXXXXXXXXXXLL 
KAGKKIRHYTMPWGSGVSICPGRFLALNEMKLFILLMVMNFDLELVDPATPVPPVDPQRW 
GFGTTQPSHEVRFRYRLRPAE 

CYP8B1      horse
            XM_001501428.1
            86% to pig 8B1
MVLWVPVLGVLLVAIVGYLCVLGLLRQRRPQEPPLDKGSIPWLG
HAVAFRKNMFEFLKHMWAKHGDVFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVEY
AEKLVLKVFGYHSVQGDHRMIHSASTKHLMGDGLEDLNKVMLDSLSLVILGPTGRSPD
ASCWREDGLFHFCYDILFKAGYLSLFGYTKDKEQDLLQAEELFIHFRKFDCLFPRFVY
SLLWPREWLEVGRLQRLFHKTLSVKHNLEKDGISNWISYMLQFLREQEVAPAMQDKFN
FMMLWASQGNTGPTSFWALLFLLKHPEAMRAVRKEATRVLGEARLEARQSFNFKVSAL
HHTPVLDSVMEETLRLGAAPTLLRVVHGDHTLKMASGQEYRLRSGDIVALFPYLSVHM
DPDIHPDPTAFKYDRFLNPNGSRKVAFYKAGKKIHHYTMPWGSGVSICPGRFLALSEM
KLFILLMVTHFDLELVDPDTPVPPVDPKRWGFGTTQPSHDVRFRYRLQPTE

CYP8A1      Canis familaris (dog)
            XM_542738.1
            84% to pig 8B1
MVFWGLVLGALLVVTTGCLYLLGVLRQRRPQEPPLDKGSIPWLG
HAMAFRKNMFEFLKHMWAKHGDVFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVKY
AEKLVLKVFGYHSGQGDYRMIHSASTKYLMGDGLEDLNKTMLDSLSLVMLGPTGQSLD
SSCWHEDGLFHFCYNVLFKAGYLSLFGYTKDQEQDLRQAEELFVQFRKFDRLFPRFVY
SLLGPREWREVGRLQRLFHKALSVKRNLEKNGISRWISYMLQYLRERGVAPAMQDKFN
FMMLWASQGNTGPTSFWALLFLLKHPEALRAVREEATQVLGEARLKARQSFDFKVSTL
HHTPVLDSVMEETLRLGAAPTLLRVVHNDHILKMASGQEYLLRSGDIVALFPYLSVHM
DPDIHPEPTTFKYDRFLNPNGSRKVDFYKAGKKIHHYTMPWGSGVSICPGRFLATNEM
KLFVLLMVTYFDLELVDPNTPVPPVDPQRWGFGTTQPSHEVRFRYRLRPTS

Cyp8b1     mouse
           GenEMBL AF090317
           Gafvels,M., Olin,M., Chowdhary,B., Raudsepp,T., Andersson,U.,
           Persson,B., Jansson,M., Bjorkhem,I. and Eggertsen,G.
           Structure and chromosomal assignment of the sterol
           12-alpha-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic
           cytochrome P-450 gene devoid of introns.
           Genomics 56, 184-196 (1999)
MTLWCTVLGALLTVVGCLCLSLLLRHRRPWEPPLDKGFVPWLGH
SMAFRKNMFEFLKGMRAKHGDVFTVQLGGQYFTFVMDPLSFGPIIKNTEKALDFQSYA
KELVLKVFGYQSVDGDHRMIHLASTKHLMGQGLEELNQAMLDSLSLVMLGPKGSSLGA
SSWCEDGLFHFCYRILFKAGFLSLFGYTKDKQQDLDEADELFRKFRRFDFLFPRFVYS
LLGPREWVEVSQLQRLFHQRLSVEQNLEKDGISCWLGYMLQFLREQGIASSMQDKFNF
MMLWASQGNTGPTCFWVLLFLLKHQDAMKAVREEATRVMGKARLEAKKSFTFTPSALK
HTPVLDSVMEESLRLCATPTLLRVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMD
PDIHPEPTAFKYDRFLNPDGTRKVDFYKSGKKIHHYSMPWGSGVSKCPGRFFALSEMK
TFVLLMIMYFDFKLVDPDIPVPPIDPRRWGFGTSQPSHEVRFLYRLKPVQ

CYP8B1     rat
           NM_031241.1
           89% to mouse 8b1
MLWGSVLGALLMAVGCLCLSLLPRHRRPWEPPLDKGFVPWLGHT
MAFRKNMFEFLKGMRAKHGDVFTLQLGGQYFTFVMDPLSFGPIIKSTQKVLDFVTYAR
ELVFKVFGYQSMDEDHQMLHVASTKHLMGQGLEDLNRAMLDSLSLVMLGPKGRSLGAR
SWCEDGLFHFCYSILFKAGFLSLFGCTKDKEQDLDEADELFRKFRRFDLLFPRFVYSL
LGPLEWVEVSQLQRLFHQRLSVEQNLEKDGISNWLGFMLRFLRERGMASSMQDKFNFM
MLWASQGNTGPTCFWALLFLLKHQDAMKAVREEATRVLGEARLEAETSFAFTLSALKC
TPVLDSVMEETLRLCATPTLLGVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMDP
DIHPEPTTFKYNRFLNPDGTRKVDFYKSGKKIHHYNMPWGSGVSICPGRFFAPSEMKT
FVLLMVMYFDFELVDPDMPVPPIDPRRWGFGTSQPSHEVRFRYRLKPMQ

CYP8B1     Monodelphis domestica (gray short-tailed opossum)
           XM_001377081.1
           48% to 8B1 human
MALWVFVFIILVSSVLVVLYALGVLRQRRAREPPLDKGPIPWFG
YTWHLSKDASSFLKKMHRRYGNIFTILLGGKYVTFVTDPLSFDAILKENRSKLDFSNF
ASQLVFKIFEFQGPKQYQKVLKSHSTKYLMGSSLAVMTQAMMDNLQVLLLELDADMKP
GLQEWKQDGLLEHCYNIVFRAGYLALFGSLPTSGKSGHIQDLLRSQKVFEEFRKFDRL
FPRAFLSALLPNEKQEMKRLRRFFWDILAPQKILEKDNVSPWIYFSQQQLADSGVSDI
GQSQNNLILLWASQGNTGIVSFWALLFLLKNPGALKAVREEAEGILRKMGKERRPGGV
PIQVEYSMLQQTPVLDSVMEETLRLVVAPFLTRSVMQDMILKMDDGREYALRKGDEVC
VFPYLFLHMDPEIYPDPTTFKYDRFLNLDGSQKVDFYKQGRRIKSYMLPWGAGPSLCP
GRFFALNEMKMFVFLMVTQYDIELVDQEVEIPPINVKRWGIGAMQPIYDVQFRYRIKP
LKSRAKAETSKVEWCWTMETLEN

CYP8B1     chicken
           NM_001005571.1
           59% to 8B1 Fugu
MTFWAVFLCTLAVSLLGGLYVLGTFRRRRPNEPPLDKGIIPWLG
YALDFRQDSSGFLSKMQRKHGDIFTVLIGGHYFTFVMDPFCFGAIVKESRSKLDFLTF
AAKLVLRVFGYKSNKDNNSALHSFNTKHLMGEGLSLLTQATMDNFQKLMLFKLSSGEE
KQPWQEAGLFHYCYNIVFRAGYLALYGTESYQGTGNKEKAHEQDLIHSNQLFTEFRKY
DRLFPRLAYAVLPPKDKVEAERLKRFFWDALSVSKDSQKENVSRWISEQDQYLAESGV
PDYMRDRFKFMMLWASQGNTGPTAFWLLLYLMKDPEAMKAVKGEVEKVLREHGQEVKP
GSPPVNITRDMLDQTPFLDSAVEETLRLVAAPILIRAVLQDVNLKMSSGREYTLRKGD
RVALFPHLSVQMNPEIHPEPHKFKYDRFVNPDGTKKDFYKNGKRLKYFNMPWGAGVST
CPGRFFATAEMKLFVFLMLTHYDLELVNDKEEIPAIDSSRWGFGTMQPVHDVRFRYRP
RV

CYP8B1      Xenopus tropicalis (Western clawed frog)
            CX973251.1 cannot extend in ESTdb
            Trace archive 413359888 234313629 248374609 continues on CF343441.1
            54% to human CYP8B1, an 8B1 ortholog
MALFLPIILALLVSVIGGLYLLGMFRKRRPDEPPLDKGTIPWLGYALDFRKNTSTFLQKMHKK
HGDIFTVQIAGYYFTFVMDPLSFGPIIKESKGNLDFEEFAKDLVLRVFGYQSFTNDHKML
EKSSTKHLMGDGLIVMTQAMMENLQNLMVHNIGSGKGEREWQQDGLFNYSYNIVFRAGYL
ALYGNEPAKNKGSKEKAKEFDRKHSDELFYEFRKYDQLFPRLAYAVLPPKDKIEAERLKR
LFWNMLSVKKTLQKENISGWIGEQHQ
QRAEQGLPEYMQDRFMFLLLWASQGNTGPASFWFLLYLLKHPEALKAVREEVEAVLKETG
QEVKPGGPLINLTRDMLMKTPVMDSAVEETLRLTAAPVLIRAVKQDMKIKMASGKDFSMR
KGDRVALFPYIAVQMDPEIHAEPEKFKYNRFLNEDGTKKTEFFKNGKKVKYYTMPWGAGS
TICPGRFFATNELKQFAFLMLTYFEFELVNPNEEIPSIDPNRWGFGTMQPTRDVQFRYRLRY*

CYP8B1    Xenopus laevis (African clawed frog)
          BU908175.1, EG582632.1 DT064227.1 BX850755.1
          53% to human CYP8B1
MALFFPIILALLASVIGGLYLLGMFRKRRSDEPPLDKGTIPWLGYALDFRKSTSNFLQKMHKKHGDIF
TVQIAGYYFTFVMDPLSFGPIIKESKANLDFEEFARELVSRVFGYQSVTHGHKMLEKSST
KHLMGDGLVVMTQAMMENLQNLMVHNIGSSKGEREWHQDGLFNYSYNVVFRAGYLALYGN
EPAKNKGKEKAKEFDRTHSDELFYEFRKYDQLFPRLAYSVLPPKDKIEAERLKRLFWNML
SVKKTLQKENISGWIGEQHQQRAEQGMPEHMQDRFMF
LLLWASQGNTGPASFWFILYLLKHPEAMRAVREEVEAVLKETGQEVKPGGPLINLTRDML
MKTPVMDSAVEETLRLTAAPVLIRAVKQDMKIKMASGNDFSIRKGDRVALFPYIAVQMDP
SIRKGDRVALFPYIAVQMDP
EPEKYKYNRFLNEDGTKKTDFFKNGKKVKYYTMPWGAGSTICPGRFFATNELKQFVFLML
TYFEFELVNPDEEIPGIDPNRWGFGTMQPTHDVQFRYRLRY*

CYP8B1    Danio rerio (zebrafish)
          CU694226.12 LINKAGE GROUP 2 72852-74384 (+) STRAND
          NO HIT IN UCSC BROWSER BUT CYP8B1, CYP8B2 and CYP8B3 ARE ADJACENT
          On CU694226.12
MALVQILLALLISVIGALYLLGSFRRRRTGEPPLEKGPIPWLGHVLEFRKDTAKFLNRM KAKHGDIFTVQLGGFYFTFITDPLSFGAVVKEARAKLDFTKFAEQLVQRVFGYHSIQSE HKVLQASSTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYSYNIVFR AGYLSLFGNESPKGTGKESVEKAKEIDRQESNDLFWEFRKYDQLFPNLAYGVLGPSEKM EAERLKRLFWSTLSVQKMRARDNISGWVSDQQQVRAEHGMQEFMQDRYMFLLLWASQGN TGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTPILDS AVEETLRLTAAPILTRAVMQDMTIIMANGQEYKIREGDRVAVFPYVVHVDPEVHPDPLT FKYDRFLNADGSRKTDFYKGGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYF DFELTNPNEQIPGIDIRRWGFGSMQSDRDIQFRYRPRI

CYP8B1      Takifugu rubripes (pufferfish)
            No accession number
            Scaffold_7782
            50% to 8B1 human
            this seq is older than the UCSC browser assembly
            Takifugu rubripes v4.0 (Oct. 2004) (JGI 4.0/fr2)
4794 MASVLLILLTFLVALLGGLYLLGVFRQRRPGE
4890 PPLDKGLIPWLGHVLEFRRNTWRFLERMEKKHGDVFTVQLAGFYITFIQDPMSFGAFVKE 5069
5070 SREKLDFRKFASHLVRRVFGYSSIQNDHDILNASSNRHLKGDGLEVMTQAMM 5225
5226 VNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRAGYLSLYGNEPFDSKISQEKAKEKD 5405
5406 RAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATKLLEYFWNVLSVQKLKGRD 5567
5568 NISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSSFWLLLFL
     MKHPEAMRSVKEEIDKVVRESGQEVKPGGPLVNLSREMLMKTPIL
     DSAVEETLRLTAAPLLTRAVLQDMTLKMADGQQYFIRQGDRVALFPYSAIQMDPEIHPDPR
     SFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQ
     FAFLMLLYFEFELINPDEEIPEIDYSRYGFGTMQPDRDLQFRYRLRY* 6329

Note: The UCSC browser has three intact and three partial CYP8B sequences
in Takifugu rubripes v4.0 (Oct. 2004) (JGI 4.0/fr2) assembly

CYP8B1a   Takifugu rubripes (pufferfish)
          UCSC Browser chrUn:138771800-138773332 (+) strand 129kb downstream
          USP14 THOC1 AQP1 CYP8B1b (other) CRHR2 MYL6 PTHR1 CCDC13 HIGD1A
          CYP8B1a (this one) GJA12/CX47.1 JMJD4 WNT9A
          3 aa diffs to our CYP8B1 fugu (old version shown above)
          note human CYP8B1 is next to CCBP2 HIGD1A CCDC13
          this gene is syntenic with Tetraodon CYP8B1a
MASVLLILLTFLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYSSIQNDH
EILNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRA
GYLSLYGNETFDSKISQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSVQKLKGRDNISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSS
FWLLLFLMKHPEAMRSVKEEIDKVVRESGQEVKPGGPLVNLSREMLMKTPILDSAVEETL
RLTAAPLLTRAVLQDMTLKMADGQQYFIRQGDRVALFPYSAIQMDPEIHPDPRSFKYDRF
LNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLYFEFELINP
DEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY*

CYP8B1a-de1b   Takifugu rubripes (pufferfish)
               UCSC browser chrUN 138769130-138769446 (+) strand 
               Scaffold_20802   Length = 2432 9 diffs with Scaffold_7782
               C-term 2.3 kb upstream of CYP8B1a
               Called CYP8B3P in P450 Blast server
DIAGAKEDMINRFISRYMFVLFWASWGNTGPSSFWLLLFL
MPWGSGISMCPGRFFATNELKQFAFLMLLYFEFELINPDLEIPEIDYSRYGFGTTQPD*D
LQFRYRSRY

CYP8B1-se1[1]   Takifugu rubripes (pufferfish)
                chrUn:392992722-392993066 (-) strand UCSC browser
                ZNF511 MED12 (this seq) NOTCH1 CCDC57
                Solo exon, 1 aa diff to CYP8B1c fugu
FXYSAVQMDPEIHPDPHSFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRF
FATNELKQFAFLMLLYFEFELINPDEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY

CYP8B1a   Tetraodon nigroviridis (freshwater puffer)
          UCSC browser chr 15 1216631-1218163 (-) strand
          98.9% to CYP8B1b
          94 kb downstream
MAPLLLILLTLLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWKFLDRM
KQKHGDVFTIQLAGFYITFIQDPMSFGAFVKESRDKLDFRKFAAHLVYRVFGYITVEGDH
ESLNTSSNRHLKGDGLEVMTQAMMSSLQNLMLHNVGPCSDHMTWREDKLFAYCYNIVFRA
GYLSLYGNEPFNSNISEEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSIQKVKSRDNISRWIWDVQESKDNAGVKEDMLSRYMFVLLWASQGNTGPSS
FWLLLFLMKHPEALRAVKEEINKVVRESGQEVKRGGPLVNLSREMLMKTPILDSAVEETL
RLSAAPLLTRAVLQDMTINMADGKKYFIRQGDRVALFPYSAVQMDPEIHPDPHSFKYDRF
LNPDGSEKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLYFELELINP
DEEIPEMDQSRYGFGTMQPDRDVQFRYRLRY*

CYP8B1a-de1b   Tetraodon nigroviridis (freshwater puffer)
               UCSC browser chr 15 1212312-1212371 (-) STRAND
               N-TERM FRAG 4 kb downstream from CYP8B1a
LLILLALLVALLGGLYLLGV

CYP8B1a-de1c   Tetraodon nigroviridis (freshwater puffer)
               UCSC browser chr 15 1206903-1207616 (-) strand
               97.9% to CYP8B1a
               9 kb downstream of CYP8B1a
MAPLLLILLTLLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWKFLDRM
KQKHGDVFTIQLAGFYITFIQDPMSFGAFVKESRDKLDFRKFAAHLVYRVFGYITVEGDH
ESLNTSSNRHLKGDGLEVMTQAMMSSLQNLMLHNVGPCSDHMTWREDKLFAYCYNIVFRA
GYLSLSGNEPFNSNISEEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREA

CYP8B1b   Tetraodon nigroviridis (freshwater puffer)
          UCSC browser chr 15 1311319-1312851 (-) strand
          98.9% (6 aa diffs) to CYP8B1a Tetraodon
          ROCK2 ROCK1 USP14 THOC1 AQP1 CYP8B1c CRHR1 MYL6 PTHR2 CCDC13
          HIGD1A CYP8B1b CYP8B1a GJA12 JMJD4
          The very high percent identity between 8B1a and 8B1b 
          Indicates a very recent duplication.
          Based on synteny CYP8B1a is the ortholog of CYP8B1a in fugu,
          But CYP8B1b is not orthologous to CYP8B1c in fugu.
MAPLLLILLALLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWKFLDR MKQKHGDVFTIQLAGFYITFIQDPMSFGAFVKESRNKLDFRKFSAHLVYRVFGYITVEG DHEGLNTSSNRHLKGDGLEVMTQAMMSSLQNLMLHNVGPCSDHMTWREDKLFAYCYNIV FRAGYLSLYGNEPFNSNISEEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQR EATKLLEYFWNVLSIQKVKSRDNISRWIWDVQESKDNAGVKEDMLSRYMFVLLWASQGN TGPSSFWLLLFLMKHPEALRAVKEEINKVVRKSGQEVKRGGPLVNLSREMLMKTPILDS AVEETLRLSAAPLLTRAVLQDMTINMADGKKYFIRQGDRVALFPYSAVQMDPEIHPDPH SFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLY FELELINPDEEIPEMDQSRYGFGTMQPDRDVQFRYRLRY

CYP8B1c   Takifugu rubripes (pufferfish)
          chrUn:138640517-138642049 (+) strand UCSC browser
          4 aa diffs to CYP8B1a fugu, 
          this is a very recent duplication of fugu CYP8B1a.
          It is not the ortholog of zebrafish CYP8B2 or CYP8B3, 
          or Tetraodon CYP8B1a or CYP8B1b.
          This gene is not syntenic with any Tetraodon seq
MASVLLILLTFLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYSSIQNDH
DILNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRA
GYLSLYGNEPFDSKISQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSVQKLKGRDNISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSS
FWLLLFLMRHPEAMRSVKEEIDKVVRESGQEVKPGGPLVNLSREMLMKTPILDSAVEETL
RLTAAPLLTRAVLQDMTLKMADGRQYFIRQGDRVALFPYSAVQMDPEIHPDPHSFKYDRF
LNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLYFEFELINP
DEEIPEIDYSRYGFGTMQPDRDLQFRYRLRY*

CYP8B1v1   Petromyzon marinus (sea lamprey)
           Assembled from trace files 
           97% identical to ver 2 (alleles)
           note: CYP8B seems to be derived from CYP7A by whole genome duplication
           CYP8A is not found in lamprey and probably arose later from an 8B 
           Duplication.
           Probable role in making petromyzonol and 
           the pheromone petromyzonol 24-sulfate.
MAGLVLFASSCVVGLLVIIGLVLFVTRRSQ (2) 
HPGEPPLDKGLIPWLGHAIEFRRNMYTFLRRMQRKHGDVFT (0)
VCLGGEYITFMLDPHDVAAVAREPRSALDFKAFARQFVLIVFGVNIKVEYPKVTSALNVS (2)
HLQGDGLVAMTDAMMSQLHLLMGPGSFNEGNGRGGCGGHGDAKWHESGLFDFCYGIVFR (2)
AGYLALFGQEPGGPARQTTHSLEVFKEFRKYDQLFPAIATSTLWP (1)
AQRKEADRLKSWFWEHLTVSLLRVREHVSPWILGRDEKLAELQADKETRDRTLFMLLWASQ (0)
GNTGPAAFWTLAYLMKHADAMAAVRAEVQQLLEATGQSDGAETREISLTRDMLVNTPVL (1)
DSVIEEMLRLRSAPILVRAVQQDMTLQVPGASGPGTKLRAGDRLAMFPHLSPHMDPEVHANPE (0)
EFKFDRFLNEDGSKKTDFFKSGRKLRYPTMPWGAGVSICPGRFFATNEIKQ (2)
FIVLMLIHYDVELSDPTTKVPDINVSRFGFGVMHPTHEISFRYRPRF*

CYP8B1v2   Petromyzon marinus (sea lamprey)
           Assembled from trace files 
           97% identical to ver 1 (alleles)
           note: CYP8B seems to be derived from CYP7A by whole genome duplication
           CYP8A is not found in lamprey and probably arose later from an 8B 
           Duplication.
           Probable role in making petromyzonol and 
           the pheromone petromyzonol 24-sulfate.
MAGLVLFASSWVVGLLVIIGLVLFVTRRSR (2)
HPGEPPLDKGLIPWLGHAIEFRRNMYTFLRRMQRKHGDVFT (0)
VCLGGEYITFMLDPHDVAAVAREPRSALDFKAFARQFVLIVFGVNIKVEYPKVTSALNVS (2)
HLQGDGLVALTDAMMSQLHLLMGPGSFNEGNGRGGCGGHGDAKWHESGLFDFCYGIVFR (2)
AGYLALFGQEPGGPARQTTHSPGVFKEFRKYDQLFPAIATSTLWP (1)
AQRKEADRLKSWFWEHLTVSLLRVREHVSPWILGRDEKLAELQADKETRDRTLFMLLWASQ (0)
GNTGPAAFWTLAYLMKHADAMAAVRAEVQQLLEATGQSDGAETQEISLTRDMLVNTPVL (1)
DSVIEEMLRLRSAPILMRAVQQDMTLQVPGASGPGTKLRAGDRLAMFPHLSPHMDPEVHADPE (0)
EFKFDRFLNEDGSKKTDFFKSGRKLRYPTMAWGAGVSICPGRFFAANEIKQ (2)
FIVLMLIHYDIEFSDPTTKVPDINVSRFPFGVMHPTHEICFRYRPRF*

CYP8B2    Danio rerio (zebrafish)
          chr2:2598909-2600450 100%
          CU694226.12 LINKAGE GROUP 2 56515-58059 (-) STRAND 100%
          Note there are two P450s next to each other due to a mirror duplication
          That includes the flanking gene GJC1
          GJC1 8B2 8B3 GJC1 JMJD4
          The UCSC browser is missing CYP8B1 but it present in CU694226.12
          GENE ORDER on CU694226.12:
          CX47.1/GJA12 8B3 41040-42575 (-) STRAND, 8B2 56515-58059 (-) STRAND,
          8B1 72852-74384 (+) STRAND
          GENE ORDER FROM Zv8 browser: WNT3A MMP16 C1QL3 GPT2 SERP1 CX47.1/GJA12,        
          8B3 8B2 (8B1 INFERRED FROM CU694226.12) CX47.1/GJA12 SERP1 JMJD4
          This location is syntenic with CYP8B1a in Tetraodon
          The duplications forming CYP8B2 and CYP8B3 are independent of the 
          duplications in pufferfish.
MESLVQILLALLLSVIGALYLLGGFRRRRTGEPPLEKGLIPWLGCVLEFRKDTVKFLQR MKAKHGDIFTVQLGGFYFTFITDPQSFGAVVKESRAKLDFT
NFADQLVERVFGYGAVEIKHKFFKNLQTTSTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYSYN IVFRAGYLSLFGNESPKGTGKESVEKAKEIDLQHSNDLFWEFRKYDQLFPNLAYGVLGP RGKMEAERLKRLFWNMLSVQKMKARDNVSGWVSDQQQVRAEHGMQEFMQDRFMFLLLWA SQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTP ILDSAVEETLRLTTAPLLTRGVMEDMTIIMANGQEYKIREGDRVSVFPYLVHIDPEVHP DPLTFKYDRFLNADGSRKTDFYKDGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLM LSYFDLELKNPNEEIPSIETRRWGFGSMHPDRDIQFRYRPRI

CYP8B2X     Fugu rubripes (pufferfish)
            No accession number
            Scaffold_21917
            59% to 8B1 human
            renamed CYP8B4
MASLLLILLTFLVALLGALYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFCRNTWRFLERMEKKHGD 
VFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYIATKADHEMLNASSNRH 
LKGDGLEVMTQAMMINLQNLMLHNVDSSSDRVTWREEKLFAYCYNIVFRAGYLSLYGNEA 
FDSKTSQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKRREATKLLEYFWNVLS 
VQKLKGRDNISRWIWDVQEGKDNAGVKEDMITR
YMFVLLWASQGNTGPSSFWLLLFLMKHPEAMRSVKEEIDKAVRESGQEVKPGGPLVKMSR 
EMLMKTPILDSAVEETLRLTAAPLLTRAVLQDMTLKMADGRQYFIRQGDRVALFPYSAVQ 
MDPEIHPDPRSFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGASMCPGRFFATNELKQFAFLM 
LLYFEFELINPDEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY*

CYP8B3    Danio rerio (zebrafish)
          chr2:2583434-2584966 1 aa diff
          CYP8B3 SEEMS TO BE THE ORTHOLOG OF HUMAN CYP8B1
          Revised the N-TERMINAL sequence
          93% TO CYP8B2 Danio, 91% TO CYP8B1 Danio
          CU694226.12 LINKAGE GROUP 2 41040-42575 (-) STRAND 100%
MESLVQILLALLLSVIGALYLLGGFRRRRTGEPPLEKGLIPWLGCVLEFRKDTVKFLQKM
KAKHGDIFTVQLGGFYFTFITDPLSFGAVVKESRAKLDFTK
FSDQLVERVFGYHPMENEHKF LQTASTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYCYNIVFRAGY LSLFGNESPKGTGKESVEKAKEIDLQHSNDLFCEFRKYDQLFPNLAYGVLGPRGKMEAE RLKRLFWSTLSVQKMRVKDNISGWISDQQQVRAELDMQEFMQDRFMFLLLWASQGNTGP SAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTPILDSAVE ETLRLTTVPLLTRGVVQDMTIIMANGQEYKIREGDRVSVFPYLVHIDPEVHPDPLTFKY DRFLNADGSRKTDFYKDGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYFDFE LTNPNEQIPDIDIRRWGFGSMHPDRDIQFRYRPRI

CYP8B4    Takifugu rubripes (pufferfish)
          chrUn:372955311-372956843 (-) strand UCSC browser
          formerly called CYP8B2 
          RIOK1 CDYL CARS SPN CYP8B4-de1b, CYP8B4 (this one) MED12-like SOX2
          5aa diffs to CYP8B2X fugu (older assembly shown above)
          This gene is in a novel location not syntenic to Danio CYP8B1,
          CYP8B2 or CYP8B3.
MASLLLILLTFLVALLGALYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFCRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYIATKADH
EMLNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRA
GYLSLYGNETFDSKISQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSVQKLKGRDNISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSS
FWLLLFLMKHPEAMRSVKEEIDKAVRESGQEVKPGGPLVKMSREMLMKTPILDSAVEETL
RLTAAPLLTRAVLQDMTLKMADGRQYFIRQGDRVALFPYSAVQMDPEIHPDPRSFKYDRF
LNPDGSKKTDFYKAGNKVKYYTMPWGSGASMCPGRFFATNELKQFAFLMLLYFEFELINP
DEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY

CYP8B4-de1b   Takifugu rubripes (pufferfish)
              chrUn:372951772-372952290 (-) strand UCSC browser
              N-term 3kb downstream
              100% to CYP8B1a fugu, 94% to CYP8B4 fugu
              This looks like 8B4 was at one time usptream of CYP8B1a
              It may have been copied taking a piece of CYP8B1a with it.
MASVLLILLTFLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYSSIQNDH
EILNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYC

9A Subfamily

CYP9A1      Heliothis virescens (tobacco budworm)
            GenEMBL U23506 (1763bp)
            Randy L. Rose, Doreen Goh, Deborah M. Thompson, Kuldeep D. Verma, 
            David G. Heckel, Linda J. Gahan, Richard M. Roe, and Ernest Hodgson.  
            Cytochrome P450 (CYP) 9A1 in Heliothis virescens:  The first member of 
            a new CYP family.  
            Insect Biochem. Molec. Biol. 27, 605-615 (1997)

CYP9A1v2    Heliothis virescens
            no accession number
            Satish Pimprale
            submitted to nomenclature committee 10/6/98
            98% identical to 9A1

CYP9A2      Manduca sexta
            GenEMBL AF172278
            Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
            Inducible P450s of the CYP9 family from larval Manduca sexta midgut
            Unpublished
            submitted to Nomenclature Committee
            sequence revised 4/14/99

CYP9A2     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP9A3      Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            99% 3 aa diffs to 9A3v2 all in N-term 22 aa
            83% to CYP9A1 Heliothis virescens, 
            note 9A3 of Pittendrigh et al. was a PCR frag 
            This is the full length sequence

CYP9A3 frag.  Helicoverpa armigera (Australian cotton bollworm) 
            no accession number
            Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O., 
            Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
            Cytochrome P450 genes from Helicoverpa armigera: expression in a 
            Pyrethroid susceptible and resistant strain. Submitted
            hacyp945
            submitted to Nomenclature Committee

CYP9A3      Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HAH000133 has 1 aa diff to CYP9A3 from Rene Feyereisen

CYP9A3v2    Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            Sequence #10 532 aa HaCypZ003a-v2Pep
            Only 4aa diffs in 125aa (not including the ends of 9A3)

CYP9A4      Manduca sexta
            GenEMBL AF172279
            Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
            Inducible P450s of the CYP9 family from larval Manduca sexta midgut
            Unpublished
            submitted to Nomenclature Committee 3/13/99
            sequence (a)
            Note: an older sequence was formerly 9A4, but it was renamed to 9E1
            this sequence was never public, so the number has been reused.

CYP9A4     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP9A4v2    Manduca sexta
            GenEMBL AF172280
            Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
            Inducible P450s of the CYP9 family from larval Manduca sexta midgut
            Unpublished
            submitted to Nomenclature Committee 3/13/99
            sequence (c)

CYP9A5      Manduca sexta
            GenEMBL AF172281
            Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
            Inducible P450s of the CYP9 family from larval Manduca sexta midgut
            Unpublished
            submitted to Nomenclature Committee 3/13/99
            sequence (b)

CYP9A6      Depressaria pastinacella (Lepidoptera: Oecophoridae)  (parsnip webworm)
            No accession number
            Weimin Li and May Berenbaum
            submitted to nomenclature committee 10/15/02
            52% to 9A1 missing from PERF to end

CYP9A7      Depressaria pastinacella (Lepidoptera: Oecophoridae)  (parsnip webworm)
            No accession number
            Weimin Li and May Berenbaum
            submitted to nomenclature committee 10/15/02
            67% to 9A6 N-terminal 134 aa piece only

CYP9A8      Spodoptera litura (common cutworm)
            GenEMBL AF525031.1
            Chang,C.-K., Wu,M.-C. and Lu,K.-H.
            Cloning of cytochrome P450 gene in the larva of common cutworm,
            Spodoptera litura
            Unpublished

CYP9A9      Spodoptera exigua (beet armyworm)
            No accession number
            Kei Shimada
            submitted to nomenclature committee 7/14/03
            89% to CYP9A8, 78% to 9A10, 56% identical to CYP9A4
            clone name sequence #1

CYP9A10     Spodoptera exigua (beet armyworm)
            No accession number
            Kei Shimada
            submitted to nomenclature committee 7/14/03 
            79% to 9A8, 78% to 9A9, 56% identical to CYP9A4 
            clone name sequence #2

CYP9A10     Spodoptera exigua (beet armyworm)
            No accession
            Katsuya Natsuhara
            Submitted to nomenclature committee Jan. 27, 2005
            Clone name S4-1
            80% to 9A13, 79% to 9A8, 64% to 9A23
            2 amino acid diffs compared to Shimadas seq.

CYP9A11     Spodoptera exigua (beet armyworm)
            No accession number
            Kei Shimada
            submitted to nomenclature committee 7/14/03
            65% identical to CYP9A8, 64% to 9A10, 53% to 9A1
            clone name sequence #3

CYP9A11     Spodoptera exigua (beet armyworm)
            No accession
            Katsuya Natsuhara
            Submitted to nomenclature committee Jan. 27, 2005
            Clone name S4-4
            66% to 9A13, 79% to 9A8, 64% to 9A22
            4 amino acid insert compared to Shimadas seq.

CYP9A12v1   Helicoverpa armigera (Australian cotton bollworm) 
            GenEMBL AY371318
            Yidong Wu & Song Chen
            submitted to nomenclature committee 8/19/03
            72% to CYP9A8 57% to partial seq CYP9A3

CYP9A12v2   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Wu Yidong
            Submitted to nomenclature committee Dec. 4, 2004
            Clone name CYP_Ger
            98% to CYP9A12v1

CYP9A12v3   Helicoverpa zea (corn earworm)
            No accession 
            Xianchun Li
            Submitted to nomenclature committee Oct. 3, 2005
            clone name: P12cDNA-2
            probable ortholog to CYP9A12v2 only 13 aa diffs

CYP9A13     Mamestra brassicae (moth)
            GenEMBL AY390260
            Martine Maibeche 
            80% to 9A10 
            submitted to nomenclature committee Sept. 12, 2003

CYP9A14     Helicoverpa armigera
            GenEMBL AY487948
            Yidong Wu & Song Chen

CYP9A14     Helicoverpa zea (corn earworm)
            No accession 
            Xianchun Li
            Submitted to nomenclature committee Oct. 3, 2005
            clone name: P14cDNA-1
            ortholog of Helicoverpa armigera CYP9A14 only 
            6aa diffs

CYP9A14     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_261 99% to CYP9A14 AY487948

CYP9A15     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            Note: this seq has two aa diffs to Grubors seq #12
            outside Grubors frameshifted region.
            The successor to Grubors seq #12 is 
            HaCypZ001a-v7Pep, but this seq has the two aa diffs
            mentioned above and 7 more outside the frameshifted
            region that is now corrected.
            HaCypZ001a-v7Pep may be an allele of the original #12 seq.
            Or it could be a very similar distinct gene.
            12 aa diffs to CYP9A15v2
            10 aa diffs to CYP9A18, one is in the same codon,
            but no mutations are the same.

CYP9A15     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            Sequence #12
            65% to 9A12, 64% to 9A17, 56% to 9A14
            Note: the name CYP9A15 refers to the original seq #12
            And its full length non-frameshifted version from
            Feyereisen. HaCypZ001a-v7Pep must be CYP9A15v2
            unless it is a second very similar gene.

CYP9A15     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_191 has 3 aa diffs to 9A15 from Rene Feyereisen Ha_02A22_C
            Contig_246 has 3 aa diffs to Contig_191, 100% in first 275aa to Rene
            Contig_255 has 1 aa diff to Contig_246

CYP9A15v2   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            HaCypZ001a-v7Pep, successor to Grubors seq #12
            See comments above.
            12 aa diffs to CYP9A15 Feyereisen
            3 aa diffs are in Grubors frameshifted region.

CYP9A16     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            only 1 aa diff to CYP9A16 of Grubor, 
            64% to CYP9A17, 62% to CYP9A12

CYP9A16     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            Sequence #4 132 aa from C-term HaCypZ007a-v1Pep
            70% to 9A13, 70% to 9A14, 67% to 9A12

CYP9A17     Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            Note: 1 aa diff to 9A17v2, 3aa diffs to CYP9A17v1 
            2 of these three diffs are at the extreme C-term in 
            the last 3 aa so these are probably seq errors.  
            This seq. represents the consensus seq between the three versions.

CYP9A17     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_200 has 1 aa diff to CYP9A17 Ha_02A22_B from Rene
            41% to CYP9J5

CYP9A17v1   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Cai-Xia Ma
            Submitted to nomenclature committee Sept. 14, 2004
            This sequence has one aa diff to Vladimir Grubors
            CYP9A12v2 fragment over 162 aa.
            Therefore, these seem to be the same gene.
            This sequence is full length and shows 93% identity to 9A12
            It does not look like an allele, so I am renaming 9A12v2 
            To CYP9A17.

CYP9A17v1   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            95% to 9A12v1, 8aa diffs in 162aa. Seq #11 HaCypZ002x-v3Pep
            from mid region of P450 
            formerly CYP9A12v2, 1 aa diff to 9A17v1 of Cai-Xia Ma

CYP9A17v1   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Vladimir Grubor
            Submitted to nomenclature committee Dec. 30, 2003
            Sequence #17 HaCypZ002y-v2Pep
            100% to 9A17v1 of Ma Seq #17
            from C-term of P450 

CYP9A17v2   Helicoverpa armigera (Australian cotton bollworm)
            GenEMBL DQ003275
            Wu Yidong
            Submitted to nomenclature committee Dec. 4, 2004
            Clone name CYP_Fen
            94% to CYP12, 4 amino acid diffs to 9A17v1

CYP9A18     Helicoverpa armigera (cotton bollworm)
            GenEMBL DQ256408
            Yidong Wu and Lina Yue
            submitted to nomenclature committee Aug. 13, 2005
            clone name YS-QJ-9
            96% to CYP9A15, might be an allele of 9A15
            21 aa diffs to CYP9A15v2

CYP9A19     Bombyx mori (silkworm)
            See Bombyx page

CYP9A19     Bombyx mori (silkworm)
            No accession number
            Junwen Ai
            submitted to nomenclature committee Jan. 31, 2007
            identical to sequence CYP9A19 (qq) on Bombyx page 

CYP9A20     Bombyx mori (silkworm)
            No accession number
            Junwen Ai
            submitted to nomenclature committee Jan. 31, 2007
            identical to sequence CYP9A20 (rr) on Bombyx page 

CYP9A21     Bombyx mori (silkworm)
            No accession number
            Junwen Ai
            submitted to nomenclature committee Jan. 31, 2007
            nearly identical to sequence CYP9A21 (ss) on Bombyx page except
            one short exon does not match.
            This exon matches to an adjacent gene sequence on the 
            genomic sequence AADK01003199.  At present we cannot tell 
            which sequence is accurate and which is chimeric.

CYP9A22     Bombyx mori (silkworm)
            See Bombyx page CYP9A tt

CYP9A23v1   Helicoverpa armigera (Australian cotton bollworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 13, 2007
            73% to CYP9A17, 71% to CYP9A12, 69% to 9A18, 67% to 9A15, 
            65% to CYP9A16, 62% to 9A14, 52% to 9A3

CYP9A23v1   Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_209 = CYP9A23v1 except for a 3 aa FFK insertion
            HAH001047 100% to Contig_209, 1 aa diff to Contig_177
            This seq is missing from Renes seq and it needs to be there.

CYP9A23v2.a Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            N-terminal
            Contig_177 = CYP9A23v1 except for a 3 aa FFK insertion and 1 aa diff
            HAH001985 100% to Contig_177
            HAH006958 100% to Contig_177
            HAH007484 has 2 aa diffs to Contig_177

CYP9A23v2.b Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            C-terminal
            Contig_210 has 1 aa diff to 9A23v1
            HAH005732 has 1 aa diff to Contig_210
            .a and .b may belong to the same gene

CYP9A24     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            64% to CYP9A16
            9A24 may be the ortholog of CYP9A16 of H. armigera

CYP9A25     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            75% to 9A23, 69% to 9A18 
            70% to 9A12v2, 67% to 9A27. 
            Genes 9A25 and 9A26 may be paralogs of CYP9A23 of H. armigera

CYP9A26     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            66% to 9A25, 65% to 9A23, 64% to 9A18

CYP9A27     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            69% to 9A18, 68% to 9A15, 
            9A27 may be an ortholog of CYP9A15 of H. armigera

CYP9A28     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            89% to adjacent 9A29, 78% to 9A30, 75% to 9A17v2 
            This one and The next 3 genes 9A28-9A31 look like 
            paralogs of CYP9A17 of H. armigera

CYP9A29     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            89% to adjacent 9A28, 77% to 9A30,
            75% to 9A31, 71% to 9A17

CYP9A30     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            77% to 9A29, 80% to 9A28, 70% to 9A17

CYP9A31     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            78% to 9A28, 76% to 9A29, 73% to 9A30,
            69% to CYP9A17

CYP9A32     Spodoptera frugiperda (the fall armyworm)
            No accession number
            Rene Feyereisen
            submitted to nomenclature committee June 22, 2007
            69% to 9A1, 66% to 9A3,
            may be an ortholog of CYP9A3 of H. armigera

CYP9A33     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_178 has 5 aa diffs to 9A23 plus two indels (one is FFK)
            HARM_contig_2 100% to Contig_178, 98% to Contig_177

CYP9A33     Helicoverpa armigera (cotton bollworm)
            No accession number
            Ji Jichao
            Submitted to nomenclature committee Aug. 27, 2012
            99% to CYP9A33 Helicoverpa armigera 1 aa diff in 287 aa
            complete seq.

CYP9A34     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_154 95% to HA-RN46_F13_CYP450 
            96% to CYP9A16, 3 aa diffs

CYP9A35     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            HA-RN46_F13_CYP450 95% to Contig_154 9A34
            98% to CYP9A16, 1 aa diff

CYP9A36    Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_c7429 
           63% to CYP9A19 Bombyx mori

CYP9A37    Zygaena filipendulae (zygaenid moth, Lepidoptera)
           No accession number
           Mika Zagrobelny Larsen
           Submitted to nomenclature committee Feb. 4, 2009
           Clone name Zygae_P450-2 
           60% to 9A19, 63% to CYP9A36

CYP9A38    Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
           No accession number
           Zhifan Yang
           submitted to nomenclature committee June 13, 2009
           66% to CYP9A20 Bombyx mori

CYP9A39    Spodoptera litura (common cutworm)
           No accession number
           Jialiang Zhou
           submitted to nomenclature committee July 28, 2009
           75% to CYP9A8, 76% to CYP9A9, 76% to CYP9A10

CYP9A40    Spodoptera litura
           No accesion number
           Zihbin Xu, Sichun Zheng, Qili Feng
           submitted to nomenclature committee April 17, 2011
           87% to CYP9A32 Spodoptera frugiperda

CYP9A41     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            64% to CYP9A38 Cnaphalocrocis medinalis

CYP9A42     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            64% to CYP9A38 Cnaphalocrocis medinalis

CYP9A43     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            66% to CYP9A20 Bombyx mori

CYP9A44     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            64% to CYP9A13 Mamestra brassicae

CYP9A45     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            61% to CYP9A20 Bombyx mori

CYP9A46     Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee June 2, 2011
            77% to CYP9A45 Heliconius melpomene

CYP9A47v1   Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            89% to CYP9A14 Helicoverpa zea

CYP9A47v2   Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            88% to CYP9A14 Helicoverpa zea

CYP9A48     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            83% to CYP9A14 Helicoverpa zea

CYP9A49v1   Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            90% to CYP9A14 Helicoverpa zea

CYP9A49v2   Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            93% to CYP9A14 Helicoverpa zea

CYP9A50     Heliothis subflexa (moth)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            87% to CYP9A17v2 Helicoverpa armigera

CYP9A50     Heliothis virescens (tobacco budworm)
            No accession number
            Hanna Heidel-Fischer
            submitted to nomenclature committee June 30, 2011
            95% to CYP9A50 Heliothis subflexa

CYP9A51     Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            89% to CYP9A25 Spodoptera frugiperda (possible ortholog)

CYP9A52     Spodoptera littoralis (cotton leafworm)
            No accession umber
            Martine Maibeche
            Submitted to nomenclature committee Jan. 20, 2012
            87% to CYP9A10 Spodoptera exigua

CYP9A53    ??

CYP9A54v1  Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP9A54v2  Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP9A54v3  Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP9A55    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP9A56    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP9A57    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

CYP9A58    Spodoptera frugiperda (the fall armyworm)

CYP9A59    Spodoptera frugiperda (the fall armyworm)

CYP9A60    Spodoptera frugiperda (the fall armyworm)

CYP9A61    Cydia pomonella (codling moth)
           No accession number
           Yang Xueqing
           Submitted to nomenclature committee March 28, 2013
           59% to CYP9A20 Bombyx mori

9B Subfamily

Cyp9b1      Drosophila melanogaster
            GenEMBL U34324(358bp)
            Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B., 
            ffrench-Constant, R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genetics 251, 290-297 (1996)

Cyp9b1      Drosophila melanogaster
            GenEMBL AC006469, chromosome 2R, region 43A1-43A2 
75% identical to AC006469 comp(54916-56640) 62% identical to CYP9B3
56640 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFY 56461
56460 NRXX 56455
56384 SKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNERLVNDMLNV 56226
56225 MRDQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVL 56046
56045 CNKLSNDVIATTAFGLKVNSFDDPENEFHTIGKTLAFSRGLPFLKFMMCLLAPKVF 55875
55806 KLTIFDSTNVEYFVRLVVDAMQYREKHNITRPDMIQLLMEAKKESKDNWTD 55654
55653 DEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAA 55474
55473 QEMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWD 55294
55293 ERFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCI 55114
55113 GNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWM 54934
54933 QLVSRK 54916

Cyp9b1      Drosophila melanogaster
            GenEMBL AC019916 10502-12238

Cyp9b2      Drosophila melanogaster
            GenEMBL U34325(358bp)
            Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B., 
            ffrench-Constant, R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genetics 251, 290-297 (1996)

Cyp9b2      Drosophila melanogaster
            GenEMBL AC006469, chromosome 2R, region 43A1-43A2 
            66% identical to CYP9B3 44% to 9C1 over I-helix to heme

Cyp9b2      Drosophila melanogaster
            GenEMBL AC019916 8190-9903
MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLT
EFYERTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLS
VMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKV
MCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLL
KLTIFDSAKVDYFARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDKWTDDEIVAQCFI
FFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMV
ISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRK
FDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIK
DLWGSASGFNFTPRSGFWMHLVPRK

Cyp9b2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP9B3      Drosophila mettleri
            GenEMBL AF083945
            Danielson,P.B., Reeves,S.A. and Fogleman,J.C.
            Isolation of a novel cytochrome P450 (CYP9B3) from Drosophila mettleri.
            Unpublished
            DU544mt

9C Subfamily

Cyp9c1      Drosophila melanogaster
            GenEMBL U34326(358bp)
            Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B., 
            ffrench-Constant, R.H. and Feyereisen,R.
            Cytochrome P450 gene clusters in Drosophila melanogaster.
            Mol. Gen. Genetics 251, 290-297 (1996)

Cyp9c1      Drosophila melanogaster
            GenEMBL AC019937 comp(1757-3443)

Cyp9c1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP9D1      Tribolium castaneum (red flour beetle)
            no accession number
            Jeff Stuart 
            submitted to nomenclature committee 8/14/98
            new1

CYP9D1      Tribolium castaneum (red flour beetle)
            GenEMBL AAX62142, NP_001034541, NM_001039452, AY920544
            Some gene models are short, corrected below
            lower case regions
mltlilgvilgaiiyyklrkpahfwakktsptchhgpllgnMWPFVV
QKKHITEIIADIYRQFPTDRYVGYYHFMTPTLLLRDVELIKQIGVKE
FDSFHDHVSVSNTNTEPLLSEALTNLPGEKWKEMRATLSPAFTSSKIKNM
YSLISECAENFVDFFQGREQDVEIKEVFSRFSNDVIATAAFGI
RVNSVQEPNNEFYAMGRSLTTFSAFQILKIFLAHLVPKIAEFFEYRVL
PRKVTDFFEGLILDNMQKREAEKIVRPDLIHLLMEARKGKLKHDNSNEG
GEGFATVEESEIGKNTKQVELTDEKIVAQALLFFFAGFETVSTGVSFMA
YELATNPHVQKKLQKEIDLTLQENHGKISYNVLQSMKYLDQVVCESLRLW
PPAPQTDRLCNKNFVIEASKPHERTFTVEKDTMVMISMFAIHRDPQYFP
DPEKFDPERFSDENKAKIVPGTYMPFGVGPRNCIgsrfalleiktlfc
hllAKFDIVPNGKTVIPIKISPSTANMVPQEGIHLTFKPRL*

CYP9D2      Tribolium castaneum (red flour beetle)
            no accession number
            Jeff Stuart 
            submitted to nomenclature committee 8/14/98
            new2 9 diff with genomic seq below (98%)

CYP9D2      Tribolium castaneum (red flour beetle)
            GenEMBL AAJJ01000243.1
       MLTTILLTLLSALIYFKLIKPASFWETRNVPHVTSWPLVGSMFPVLTQKKHFVEISQNIYTQFPNAK (2)
       CVGYVLFTKPTLLIRDLDLLKQIGVK
8454   EFDSFHDHLPFVTEATEPLLSKSLLNLLGDEWRKMRATLSPAFTSSKMKHMYQLICECAE  8633
8634   RFTQHFGNRTVDVEIKDVFSRFSNDVIASAAFGIQVDSLKEPGNEFYSMGKAVTSILNGF  8813
8814   QMVKVFLAL (2) 8840
8887   LFHAIFQLIQFRAIPPKVTSFFYDIIIDNIKKRKNEGIVRPDMVHLLMEAQSGKLKHDNN  9066
9067   TEQVDGFATVEESEIGKNSNKIQLTDELIVAQALIFLLAGFDSVSTGLSFIAYELATNPD  9246
9247   VQKKLQEEIDSVLEKNQGKVMYNEIQSMKYLDQVLC (1) 9354
9922   ETLRLWPPAPQTDRYCNKDFPIDANFTIEKGVMIEIPIFAIHRDPQYFADPDKFDPGRFS  10101
10102  DENKSKIVPGTYIPFGVGPRNCI (1) 10170
10212  GSRFALLEIKILFWHLLSKFDILPNEKTVVPFKLCKRSSSLVPNEGIHLRFRPRK*  10379

CYP9D3      Tribolium castaneum (red flour beetle)
            GenEMBL AAJJ01000243.1
      MLTIILSVVLGALIYYKLIKPASFWEERNITHASAWPLIGSMWESVIQKKNFNEISADIYKKYPNDR (2)
      YVGYMQFSNPALLIRDLNLIKQIGVKA
6156  FDHFHDHLAFVGVKAEPLFSKSLAILQGEEWKQMRATLSPVFTSSKMKNMYHLIYECAEN  6335
6336  FAKHFQGRKEDVEVKDIFSKFTNDVIATAAFGIQINSLEEPNNEFYLMGKLLTTFKGWQ  6512
6513  LIN (2) 
      NNTILYRLIFEILFQLTKLNIFNQKVIKYFYDIIIDNIHKREK  6692
6693  EGIIRPDLIHLLMEARKGKLKHDNSNEGGDGFATVEESDIGKNSKQLELTEDLMVAQALI  6872
6873  FFFAGFETISTSFSFTAYELATNPDVQKKLQKEIDSAFQENHGKISYNVLQSMKYLDQVV  7052
7053  S(1)ESLRLWPPAPQTDRFCNTDFVLEPTKPDERRFTIEKGVTTIIPI  7232
7233  YGIHRDPQYFPNPDKFDPERFSDENKAKIVPGTYMPFGVGPRNCI (1)
7413  GSRLALLELKTLFFHLLSKCDIVTNSKTVIPLKISPNNGNITPKEGIHLSFKPRKINGKM*  7595

CYP9D4      Tribolium castaneum (red flour beetle)
            GenEMBL XP_967481
            78% to 9D7, 67% to 9D1

CYP9D5      Tribolium castaneum (red flour beetle)
            GenEMBL AAJJ01000243.1
            87% to 9D3
1081 MLTIILSVVLGALIYYKLIKPASFWDERNITHASAWPLIGSMWESVIQKKNFNEISSDFY 1260
1261 KKYPNDR (2?) 
1333 YVGYMQFSNPVLLIRDLDLIKQIGVKVFDNFHDHLAITGIKTDPLFSKSLIVLRGEEWK 1509
1510 QMRATLSPAFTSSKMKNMYHLIYECAENFAKHFQDEKKNVEVKDIFSKFTNDVIATVAFG 1689
1690 IQINSLKEPNNEFYSMGKLLTTFKGFELMKFFFALALPQIFE (0) 1815
1868 LTKLSLFNQKVTNFFRNIIIDNMHKREKDGIVRPDLIHLLMEARKGKLKHDNSN-EGG 2038
2039 DGFATVEESEIGKNSKKMELTDDLMVAQALLFFFAGFETISTGFSFMAYELATNPDVQKK 2218
2219 LQKEIDLTLQENHGKISYNVLQSMKYLDQVV 2311
2376 ESLRLWPPAPQTDRFCNTDFVLEPTKPHERRFTIERGVTIIIPIYGIHRDPEYFPNPDKF 2555
2556 DPERFSDENKAKIVPGTYMPFGVGPRNCI 
     GSRLALLELKTLFFH 2735
2736 LLSKCDIVTNSKTVIPLKISPNNGNITPKEGIHLTFKPRNVA 2861

CYP9D6      Tribolium castaneum (red flour beetle)
            GenEMBL AAJJ01000243.1 runs off the end
            93% to 9D4 
2 TDRFCNTHFVLEPTKPHERRFTIEKGVTVVFPIYGIHRDPQYFPNPDKFDPERFSDENKA 181
182 KIVPGTYMPFGVGPRNCI (1) 235
283 GSRLALLELKTLVFHLLSKCDIVTNSKTVIPLKISPNNANITPKEGIHLTFKPRNVA 453

CYP9D7      Tribolium castaneum (red flour beetle)
            GenEMBL XP_973677
            Gene model fused to another seq 
            this seq only seen in tribolium, delete the fusion part
            78% to 9D4
MLTIILSVIFCALIYYKL
MKPANFWKKRNITHVPSWPLVGNMLDSIIQKKHILEISTDIYKKYPDDRYVGYMQFTNPTLLIRDIDLIK
QIGVKIFDSFHDHVTAAGIETEPLLNQSLISLHGEDWKRMRATLSPAFTSSKMKNMYHLIYECSENFAQH
FQDGKQNVEVKDIFSKFTNDVIATAAFGIQVNSLKEPDNEFYSMGKALTTFQGFQLIKFFFVQLVPKIAE
ILKVRFLNPKVANFFTSIIINNMQKRERDGIIRPDLIHLLMEARKGKLKYDKGNEFGDGFATVEESEIGK
NTKQVELTDDLIVAQALLFFFAGFDTVSTGASFLAHELATNPDVQKKLQEEIDMVLEENHGKISYTRIQS
MKYLDQVISESLRLWPPAPQTDRFCNTDFVLEPTKPHERRFTIEKGVTTIIPIYGIHRDPQYFPNPDKFD
PERFSDENKAKIVPGTYMPFGVGPRNCIGSRFALLELKTLFFHLLSKCDVIPNEKTVIPLKISPNNASIT
PKEGIHLTFRPRNFVQFKKSF

CYP9D8      Tribolium castaneum (red flour beetle)
            GenEMBL XP_973646, AAJJ01000243.1
            AAJJ01000243.1 around 88kb
            89% to 9D4, runs off the end of the contig
MLTIILSVVLGALIYYKLIKPASFWEERNITHVSAWPLVGN
87975MWSTFIQKKNFNEISNDIYKKYPNDRYVGYMQFTDPVLLIRDLDLIKQIGVKVFDNFRDHHAVAGFKTEP
LFNKSLAFLEGEEWKQMRATLSPAFTSSKMKNMYHLIYECAENFAKHFQGKKQDVEVKDVFSRFTNDIIA
TVAFGIQINSLEERNNEFYLSGKSVTTFSGKQLLKFFAAQVIPQVFEFFKVGVFDQKIVKYFNDIIIDNM
HKREKEGIIRPDLIHLLMEARKGKLKHDNSNEGGDGFATVEESDIGKNSKKMELTDELMVAQALLFFFAG
FETISTGASFLAHELATNPDVQRKLQEEIDSVLEENQEKISYTTIQSMKYLDQVIS

CYP9E1      Diploptera punctata (cockroach)
            no accession number
            Rene Feyereisen
            submitted to Nomenclature Committee
            77% identical to CYP9E2

CYP9E2      Blatella germanica (German cockroach)
            no accession number
            Jeff Scott
            submitted to nomenclature committee 3/8/99
            77% identical to CYP9E1

CYP9F1      Drosophila mettleri
            GenEMBL AF083947
            Danielson,P.B., Al-Zahrani,A. and Fogleman,J.C.
            Isolation of a novel CYP9 cytochrome P450 from Drosophila mettleri 
            Unpublished
            46% identical to CYP9B3 46% to CYP9B4 47% to CYP9B5 38% to CYP9A1
            44% to 9C1 partial seq.

Cyp9f2      Drosophila melanogaster
            GenEMBL AC017132 AC017240 AC009741 AC017170 AC007594 
            ESTs AA735946 AI113499 AI259899
            78% IDENTICAL TO Cyp9f1

Cyp9f2      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

Cyp9f3p     Drosophila melanogaster
            GenEMBL AC017132 AC017240 AC009741 AC017170 AC007594 
            PLUS ESTs

CYP9F4      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP9F1
            65% to 9F2 (364 aa)

CYP9F4      Lucilia sericata (sheep blowfly)
CYP9F5      Lucilia sericata (sheep blowfly)

CYP9F6      Bactrocera dorsalis (Oriental fruit fly) 
            No accession number
            Yong Huang
            submitted to nomenclature committee Sept. 13, 2012
            57% to CYP9F1 D. mettleri
            clone name 639

CYP9G1      Bombyx mori (silkworm)
            no accession number
            Manabu Kamimura
            submitted to nomenclature committee 3/22/99
            42% identical to CYP9E2

CYP9G2      Plutella xylostella (L.) (diamondback moth)
            GenEMBL AB096739
            Ben-Chang,S. and Chuan-Ling,Q.
            Molecular Cloning and Complete cDNA Sequence of Cytochrome P450 in
            Plutella xylostella (L.)
            Published Only in Database (2002)
            49% to 9G1

CYP9G2     Plutella xylostella 
           Gene number CCG014982.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           missing N-term

CYP9G3     Bombyx mori (silkworm)
           ESTs CK508550 BP125176 AU000984 CK510649 BP127468
           BAAB01164136.1 BAAB01189844.1 BAAB01100167.1 BAAB01034600.1
           59% to CYP9G1
           See silkworm page for sequence

CYP9G3-de9b10b   Bombyx mori (silkworm)
           BAAB01034600.1 pseudogene detritus exons downstream of CYP9G3
2492 DFLFNVANSIHIDPIYHTEPDTFNPARFLVENEYQMREFTFMPFSIGPRNFF
4065 GKGFALL*IKLILYYLVLNFKVMKFMKTQNPIKLIQHEFNLEV 4193

CYP9G4      Plutella xylostella (L.) (diamondback moth)
            No accession number
            Anita Bautista
            Submitted to nomenclature committee Dec. 10, 2005
            Clone name Sequence 2. 6XYR 17 fragment (C-terminal)
            63% to CYP9G2 61% to 9G1, 58% to 9G3

CYP9G4      Plutella xylostella (L.) (diamondback moth)
            FJ023535, EST BP937771 (partial seq)
            Ji Hyeong Baek
            Submitted to nomenclature committee Aug. 14, 2008
            99% to 9G4 fragment of Bautista, (1 aa diff in 124 aa)
            70% to 9G2, 55% to 9G3, 54% to 9G5, 50% to 9G1 
            note: 9G1 and 9G5 have 30 missing amino acids in the middle region
            complete sequence

CYP9G4     Plutella xylostella 
           Gene number CCG014981.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011

CYP9G5      Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_167 78% TO CYP9G3, 51% to CYP9G1
            HARM_contig_3 has 3 aa diffs to Contig_167

CYP9G6      Danaus plexippus (monarch butterfly)
            EY269870.1 EY257342.1 EY274447.1 ESTs
            86% to 9G7, 57% to 9G3
MIIEIVVFILTSLIIYFIYIHKSIHKYFDDRGIKYLPGVPIFGNNFRSWFLKRHLLDDLD
SVYKAFPEERYVGYIEGTTKIIIIRDPEITRNITVKDFQHFTDHKTFFSEETEPLFGGSL
FSMKGERWHSMRTTLSPAFTSSKMRLMMPFMSEISSNIVEYLKGHV
NEYVDVQDLMRRYTNDVIASAAFGLQVNSVKDRDNEFFNIGRDLFSFTFFQRF
YMIFVALFPNFTKNLGITIFPKKVMHFFKGLVVNTMQHREKNNIHRPDMIQLLMEASKGT
LKDESDKSQTNEASKQKPEKEWTLEEIASQVFIFFAAGYETSASTLVMCVHELALNPDVQ
EKLYQEIKEYKDKHGEITFEHIHNLKYLDCVLNETSRKWSA
ALIMDRACTIPYELPPPREGLKPVQLQPGDVVYNMVNCIHMDPIYHP
(missing about 89 aa)

CYP9G7      Danaus plexippus (monarch butterfly)
            EY256661.1 EY258344.1 ESTs
            86% to 9G6, 57% to 9G3
XXXXXXVFLLTSLIVYFIYIHKSIHKYFDDRGIKYLPGVPFFGNNLRSSFLKVHVLEDLEAV
YKAFPEERYVGYIEGTTKIIIIRDPEVMRNITVKDFQHFTDHKTFVSEDSEPLFGRSLFF
MKGERWHSMRTTLSPAFTSSKMKLMMPFMSEISTNIVEYLKGHVNEDVDVQ
DLMRRYTNDVIVSAAFGLPVNSVKDRDNE
FFTIGRDLFSFTFFQKIYSILVAFPNFMKKLGITVFPKKVINFFKGILVNTMQNREKNNI
HRPDMIQLLMEASKGILKDESDTNGNKSQNNEASKQKPIKEWSVEELSSQVFIFFAAGYE
SSASTLVMCVHELALNPDVQEKLYQEIKEFXDKHGEITFEHIHNLKYLDCVLSETSRKMVN
(missing about 126 aa)

CYP9G8     Manduca sexta 
           No accession number
           Yannick Pauchet
           Submitted to nomenclature committee April 7, 2009
           confidential

CYP9G9      Heliconius melpomene (common postman butterfly)
            No accession number
            Ritika Chauhan and Richard ffrench-Constant
            Submitted to nomenclature committee Feb. 9, 2011
            65% to CYP9G3 Bombyx mori

CYP9G10    Plutella xylostella 
           Gene number CCG014978.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           73% to CYP9G2 Plutella xylostella AB096739

CYP9G11v1  Plutella xylostella 
           Gene number CCG003485.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           98% to CCG013884.1 (7 aa diffs)
           61% to CYP9G2 Plutella xylostella AB096739

CYP9G11v2  Plutella xylostella 
           Gene number CCG013884.1
           Weiyi He
           Submitted to nomenclature committee Dec. 4, 2011
           missing 73 aa at N-term
           98% to CCG003485.1

CYP9G12    Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012

Cyp9h1      Drosophila melanogaster
            GenEMBL AC017648 8657-10342 also AC005450

Cyp9h1      Drosophila pseudoobscura
            See D. pseudoobscura page on this server for sequence
            Obtained from UC Santa Cruz Browser

CYP9J1      Aedes aegypti strain RED yellow fever mosquito
            GenEMBL AF390099  
            Isabelle Morlais
            Low 40% range to other CYP9 members
            40% to 9A1, 40% to 9F1, 41% to 9D1

CYP9J1/9J2v2 Aedes aegypti (yellow fever mosquito)
             probable allele of 9J2 gene

CYP9J2      Aedes aegypti (yellow fever mosquito)
            GenEMBL AF329892  
            Isabelle Morlais
            96% to 9J1
            Low 40% range to other CYP9 members
            40% to 9A1, 40% to 9F1, 41% to 9D1

CYP9J2      Aedes aegypti (yellow fever mosquito)

CYP9J3      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPr3l1
            This gene cluster includes CYP9L1, L2 and L3

CYP9J4      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPr3l2
            This gene cluster includes CYP9L1, L2 and L3

CYP9J5      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPr3l6
            This gene cluster includes CYP9L1, L2 and L3

CYP9J6      Aedes aegypti (yellow fever mosquito)

CYP9J6      Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I2.1

CYP9J7      Aedes aegypti (yellow fever mosquito)

CYP9J7      Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T1.5

CYP9J8      Aedes aegypti (yellow fever mosquito)

CYP9J8      Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T2.2

CYP9J9      Aedes aegypti (yellow fever mosquito)

CYP9J9v1    Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T2.3

CYP9J9v2    Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T2.1

CYP9J9v3    Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T1.3

CYP9J10     Aedes aegypti (yellow fever mosquito)

CYP9J10-de2b  Aedes aegypti (yellow fever mosquito)

CYP9J10-de1c  Aedes aegypti (yellow fever mosquito)

CYP9J10v1   Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6T2.5

CYP9J10v2   Aedes aegypti (yellow fever mosquito)
            No accession number
            David, J-P  and Dauphin-Villemant, C.
            I-helix to heme fragment
            Clone name 6I1.5

CYP9J11     Anopheles funestus 
            No accession number
            Dolphine Achieng Amenya, Lizette Koekemoer 
            submitted to nomenclature committee 7/6/04
            Contig 1 
            80% to CYP9J5
            probable ortholog of CYP9J5

CYP9J12     Anopheles funestus 
            No accession number
            Dolphine Achieng Amenya, Lizette Koekemoer 
            submitted to nomenclature committee 7/6/04
            Contig 3 
            84% to CYP9J3
            probable ortholog of CYP9J3

CYP9J13     Anopheles funestus 
            No accession number
            Dolphine Achieng Amenya, Lizette Koekemoer 
            submitted to nomenclature committee 7/6/04
            Contig 5 
            84% to CYP9J4
            probable ortholog of CYP9J4

CYP9J14     Anopheles funestus 
            No accession number
            Dolphine Achieng Amenya, Lizette Koekemoer 
            submitted to nomenclature committee 7/6/04
            Contig 7 
            55% to CYP9J5
            not an ortholog of other Anopheles CYP9Js

CYP9J15     Aedes aegypti (yellow fever mosquito)

CYP9J16     Aedes aegypti (yellow fever mosquito)

CYP9J17     Aedes aegypti (yellow fever mosquito)

CYP9J18v1   Aedes aegypti (yellow fever mosquito)

CYP9J18v2   Aedes aegypti (yellow fever mosquito)

CYP9J19     Aedes aegypti (yellow fever mosquito)

CYP9J20v1   Aedes aegypti (yellow fever mosquito)

CYP9J20v2   Aedes aegypti (yellow fever mosquito)

CYP9J20     Aedes aegypti (yellow fever mosquito)

CYP9J21     Aedes aegypti (yellow fever mosquito)

CYP9J22     Aedes aegypti (yellow fever mosquito)

CYP9J23     Aedes aegypti (yellow fever mosquito)

CYP9J24     Aedes aegypti (yellow fever mosquito)

CYP9J25P    Aedes aegypti (yellow fever mosquito)

CYP9J26     Aedes aegypti (yellow fever mosquito)

CYP9J27     Aedes aegypti (yellow fever mosquito)

CYP9J28     Aedes aegypti (yellow fever mosquito)

CYP9J29     Aedes aegypti (yellow fever mosquito)

CYP9J30     Aedes aegypti (yellow fever mosquito)

CYP9J31     Aedes aegypti (yellow fever mosquito)

CYP9J32     Aedes aegypti (yellow fever mosquito)

CYP9J33    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 17
           62% to 9J23 Aedes, 61% to 9J5 Anoph.

CYP9J33    Culex pipiens

CYP9J34    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 18
           59% to 9J5 Anoph., 67% to 9J28 Aedes

CYP9J34    Culex pipiens

CYP9J35    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 19
           76% to 9J9v1 Aedes, 58% to 9J4 Anoph.

CYP9J35    Culex pipiens

CYP9J36    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 20
           57% to 9J4 Anoph., 76% to 9J10 Aedes

CYP9J36    Culex pipiens

CYP9J37    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 21
           63% to 9J16 Aedes, 55% to 9J4

CYP9J37    Culex pipiens

CYP9J38    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 22
           55% to 9J4 Anoph, 69% to 9J8 Aedes

CYP9J38    Culex pipiens

CYP9J39    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 23
           63% to 9J26 Aedes, 57% to 9J5 Anoph.

CYP9J39    Culex pipiens

CYP9J40    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 24
           60% to 9J5 Anoph., 66% to 9J22 Aedes

CYP9J40    Culex pipiens

CYP9J41    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 25
           58% to 9J7 Aedes, 56% to 9J5 Anoph.

CYP9J41    Culex pipiens

CYP9J42    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 30
           53% to 9J5 Anoph., 67% to 9J6 Aedes

CYP9J42    Culex pipiens

CYP9J43    Culex_quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           submitted to nomenclature committee 7/25/07
           sequence 34
           55% to 9J5 Anoph., 68% to 9J6 Aedes

CYP9J43    Culex pipiens

CYP9J44    Culex pipiens

CYP9J45    Culex pipiens

CYP9J46    Culex pipiens

CYP9J47    Culex pipiens

CYP9J48    Culex pipiens

CYP9K1      Anopheles gambiae (malaria mosquito)
            no accession number
            Hilary Ranson
            submitted to nomenclature committee 1/31/02
            clone name 105
            41% identical to CYP9E2

CYP9K1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPs1x2

CYP9K1      Anopheles funestus 
            No accession number
            Ashley Vaughan, Dolphine Achieng Amenya, Hilary Ranson, 
            Lizette Koekemoer 
            submitted to nomenclature committee 3/17 /05
            76% to CYP9K1
            ortholog of Anopheles gambiae CYP9K1 

CYP9L1      Anopheles gambiae (malaria mosquito)
            no accession number
            Dimitra Nikou
            submitted to nomenclature committee 2/25/02
            clone name 18B07 
            41% to 9K1

CYP9L1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPr3l5

CYP9L2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPr3l4

CYP9L3      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPr3l3

CYP9L4      Anopheles funestus 
            No accession number
            Ashley Vaughan, Dolphine Achieng Amenya, Hilary Ranson, 
            Lizette Koekemoer 
            submitted to nomenclature committee 3/17/05
            76% to CYP9L2 and 9L3
            cannot assign ortholog from Anopheles CYP9Ls without map info

CYP9M1      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPp3r1

CYP9M2      Anopheles gambiae (malaria mosquito)
            GenEMBL 
            Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
            See the paper: Evolution of supergene families associated with 
            insecticide resistance.
            Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
            Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
            Science 298, 179-181 (2002)
            Anopheles map name CYPp3r4

CYP9M3     Anopheles funestus 
           No accession number
           Dolphine Achieng Amenya, Lizette Koekemoer 
           submitted to nomenclature committee 7/6/04
           Contig 2 
           84% to CYP9M2
           probable ortholog of CYP9M2

CYP9M4     Aedes aegypti (yellow fever mosquito)

CYP9M5     Aedes aegypti (yellow fever mosquito)

CYP9M6     Aedes aegypti (yellow fever mosquito)

CYP9M7     Aedes aegypti (yellow fever mosquito)

CYP9M8     Aedes aegypti (yellow fever mosquito)

CYP9M9     Aedes aegypti (yellow fever mosquito)

CYP9M10    Culex quinquefasciatus (southern house mosquito)
           No accession number
           Osamu Komagata
           Submitted to nomenclature committee July 10, 2007
           68% to CYP9M6

CYP9M10    Culex pipiens

CYP9M10-de1b   Culex pipiens

CYP9M11P   Culex pipiens

CYP9M12    Culex pipiens

CYP9M13P   Culex pipiens

CYP9M14    Culex pipiens

CYP9N1     Mayetiola destructor (Hessian fly)
           No accession number 
           Omprakash Mittapalli, Richard Shukle
           Submitted to nomenclature committee Nov. 30, 2004
           clone name HfP450-3 and HfP450-4
           Two clones have the same amino acid sequence
           Missing the C-terminal
           40% to CYP9J4 in the first 323 amino acids

CYP9P1      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7a
            40% to Cyp9f2 Drosophila melanogaster. 50% to 9J8 partial seq.
            63% to CYP9P2
            formerly CYP335A1

CYP9P2      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7b
            40% to CYP9K1 Drosophila melanogaster. 54% to 9J7 partial seq.
            63% to CYP9P1
            formerly CYP335A2

CYP9P3     Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9P4     Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9P5     Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9P6     Linepithema humile (argentine ant)
           No accession number
           
CYP9P7     Linepithema humile (argentine ant)
           No accession number
           
CYP9P8     Linepithema humile (argentine ant)
           No accession number
           
CYP9P9     Linepithema humile (argentine ant)
           No accession number
           
CYP9P10    Linepithema humile (argentine ant)
           No accession number
           
CYP9P11    Linepithema humile (argentine ant)
           No accession number
           
CYP9P12    Linepithema humile (argentine ant)
           No accession number
           
CYP9P13    Linepithema humile (argentine ant)
           No accession number
           
CYP9P14    Linepithema humile (argentine ant)
           No accession number
           
CYP9P15    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           68% to CYP9P11 Linepithema humile

CYP9P16    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           66% to CYP9P9 Linepithema humile

CYP9P17    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           68% to CYP9P11 Linepithema humile

CYP9P18    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           66% to CYP9P9 Linepithema humile

CYP9P19    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           67% to CYP9P12 Linepithema humile

CYP9P20P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           59% to CYP9P9 Linepithema humile

CYP9Q1      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7c
            39% to CYP9E 42% to 335A1 
            57% to CYP9Q2
            formerly CYP335B1

CYP9Q2      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7d
            57% to CYP9Q1
            formerly CYP335B2


CYP9Q3      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7e
            58% to CYP9Q2
            formerly CYP335B3


CYP9R1      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7f
            44% to CYP9Q2
            formerly CYP335C1

CYP9R2P    Linepithema humile (argentine ant)
           No accession number
           
CYP9R3     Linepithema humile (argentine ant)
           No accession number
           
CYP9R4     Linepithema humile (argentine ant)
           No accession number
           
CYP9R5     Linepithema humile (argentine ant)
           No accession number
           
CYP9R6     Linepithema humile (argentine ant)
           No accession number
           
CYP9R7     Linepithema humile (argentine ant)
           No accession number
           
CYP9R8     Linepithema humile (argentine ant)
           No accession number
           
CYP9R9     Linepithema humile (argentine ant)
           No accession number
           
CYP9R10    Linepithema humile (argentine ant)
           No accession number
           
CYP9R11    Linepithema humile (argentine ant)
           No accession number
           
CYP9R12    Linepithema humile (argentine ant)
           No accession number
           
CYP9R13    Linepithema humile (argentine ant)
           No accession number
           
CYP9R14    Linepithema humile (argentine ant)
           No accession number
           
CYP9R15    Linepithema humile (argentine ant)
           No accession number
           
CYP9R16    Linepithema humile (argentine ant)
           No accession number
           
CYP9R17    Linepithema humile (argentine ant)
           No accession number
           
CYP9R18    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           75% to CYP9R6 Linepithema humile

CYP9R19    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP9R9 Linepithema humile

CYP9R20    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           73% to CYP9R6 Linepithema humile

CYP9R21    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           73% to CYP9R14 Linepithema humile

CYP9R22P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           76% to CYP9R6 Linepithema humile

CYP9R23P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           64% to CYP9R9 Linepithema humile

CYP9R24P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           50% to CYP9R9 Linepithema humile

CYP9R25P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           43% to CYP9R9 Linepithema humile

CYP9R26    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           73% to CYP9R7 Linepithema humile

CYP9R27    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           76% to CYP9R9 Linepithema humile

CYP9R28P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           58% to CYP9R9 Linepithema humile

CYP9R29    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP9R6 Linepithema humile

CYP9R30    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           72% to CYP9R10 Linepithema humile

CYP9R31    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           79% to CYP9R13 Linepithema humile

CYP9R32    Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           73% to CYP9R10 Linepithema humile

CYP9R33P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           50% to CYP9R8 Linepithema humile

CYP9R34P   Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           48% to CYP9R9 Linepithema humile

CYP9S1      Apis mellifera (honeybee)
            WGS section genbank
            Submitted by May Berenbaum 2/11/04
            AmGroup14.7g
            49% to CYP9R1
            renamed CYP9
            formerly CYP335D1

CYP9T1      Ips paraconfusus (California fivespined ips, bark beetle)
            No accession number
            Dezene Huber
            Submitted to nomenclature committee May 19, 2005
            38% to 9D1

CYP9T1      Ips confusus (Pinyon Ips, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on August 28, 2006
            Full length sequence
            98% to 9T1, only 8 aa diffs
            clone name #1

CYP9T2      Ips pini (pine engraver, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            full length
            94% to CYP9T1
            Clone name EST 2G06

CYP9T3      Ips pini (pine engraver, bark beetle)
            No accession number
            Claus Tittiger
            Submitted to nomenclature committee on Oct. 20, 2010
            93% to CYP9T2, 94% to CYP9T1 Ips paraconfusus

CYP9U1      Lucilia cuprina (Australian blowfly)
            No accession number 
            Zhenzhong Chen
            Submitted to nomenclature committee March 17, 2005
            Clone name Lc_CYP9F2 
            50% to 9F2 52% to 9F4 (352 aa)

CYP9V1v1    Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee June 29, 2005
            44% to 9D1 44% to 9T1

CYP9V1v2   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           98% to CYP9V1v1 (8 aa diffs)

CYP9V2v1    Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V12ic4
            68 amino acids from heme to end
            94% to 9V1, 3 aa diffs to CYP9V2v2

CYP9V2v2    Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V117ic4
            68 amino acids from heme to end
            94% to 9V1, 3 aa diffs to CYP9V2v1

CYP9W1      Tribolium castaneum (red flour beetle)
            GenEMBL XP_972391
            51% to CYP9D7
MWYVYLSIFCGFLALFIYYKIIKPANFWKKRNVPHESTFALLQRKHPATILTQLYQKHKDQRYVGYLQLN
HPFLMIRDLELIKQLTVKDFESFHDHYPFSYAKNDPILGKSLLMLNGQDWKQMRATLSPAYTTNKLKNMH
QLMTECAQNFVGHFKGREKVAVDMKDIFTRFTTDVIASTAFGIKTDSLNQPNNRFFLMAKSLSKFGFIQV
VKILISSFAKVGIFPSSVVNYFGTIIKSNIRERKQSCIVRPDMIHLMLEANKGQANQLTDDDIVAQAMTF
FFAGFETVATACSFMAYELAIHPEIQQKLQAEIDSVGGVTYESLLSMKFLDQVVSESLRLWPPGFQIERM
CTKSYKIEPKNHNEKGIVLEEGVSLIIPVIALHHDPDLFPEPDRFDPERFSEANRSQIVPGSYLPFGVGP
RNCIASRFALLEIKTLFFHMLSKFDIVPIDTTQIPLKLSTKKMHLEPEKGFRLGIRPRKV

CYP9X1      Tribolium castaneum 
            GenEMBL XP_972443
            52% to 9D7
MLLLLVLGVLLSCIWTYYKIIKPVKYWQERDVTHARAWPIVGSLNQVTLKKKHIADAIDEIYQHFPNQRC
VGYMHFTTPFLMVRDLDLIKKITVKDFDHFQDRLASKTIKTDPLLSKSLLSLGGENWKRMRATISPVFTS
SKMKFLFGLMDECAKNFTGHFTQNETKLEMKDVFSKFANDVIASTAFGIRIDSLQDPTNEFYKLGSSFIN
FGWWDIAKVLVMQLSPGLANLLQLRVFSEETSTFFRSLVKDNIRKRQSEGIIRPDLIQLLMQAQNGDEIQ
HSSEKIALTEDHFVSQALTFFIAGFETVSTAACFMAQELALNPHIQKRLQVEIDSVLENHKGDISYETLQ
SMKYLDQVVEETLRLWPPATQTDRLCVKSYVIEPVNPKEKVVFVEKGVSVLVPVMSIQRDSSFWEKPNKF
DPERFSEENRAKIVPGTYLPFGTGPRNCIGSRFALLELKILFFHLLAKFILVPCDNTPIPLKLDPKKLTM
SPENGFQLSLRRRLLSP

CYP9Y1      Tribolium castaneum 
            GenEMBL XP_972348
            49% to 9AB1
            gene model too long 
            delete the fusion part at N-term
MLAVLLLVFVFLAVIYFKLVVPFFYWQKRDIFYVKPWT
RFRKVFLGKESFAEAVRAAYDEHPDKRYYGSYQFLQPSLFVRDLDLIKAITVKDFEHFTDHSAFTSEKTD
PILGLNLFSLKGQKWREMRSTLSPAFTGSKMRAMFTLIAQTAESFTQYLLGLGQGVVEVEMKDTCTKFTN
DVIANCAFGIECNSLLNPENEFYKMGTMVSKPSPWRLFKTLPPTISDFFLRIIKDAIIVREQQGIVRPDM
IHLLLEARKGRLKHDKIESNEPGFATVQESTIGQNEKSLQITDELITAQALVFFIAGFTTSSSLMSFLAY
ELVVNPEIQKKMQKEIDAFLDREFSYEQVLQMKYLDQVVSEALRKYPPGYVLNRICVKDYVIKPKQEGEK
VAVIEKGCLVAIPVIALHYSPEFFPDPEKFNPERFSDENKGKILPGSYIPFGLGPRNCIGSRFALLEIKV
LLVKLLAKFDLVPVDKTVIPLKFAKTLGLDAKGGIWVGLKKRT

CYP9Z1      Tribolium castaneum 
            GenEMBL XP_975381
            66% to 9Z4, 56% to 9Z5
MILLCLIAVIVILSYRFLYRPHKYWLERGVIQGNPKPLLGHFMGTTFHKQSFADCIQMVYNMAPNSRYCG
MYQFTMPTLVVRDPDLIKQITVKDFDYFLNHRTFIPEECDALWGKNLFALTNQKWRDMRSTLSPAFTGSK
MKFMFPLISETAEYFIRHFLSKQEDVVTVEMKDAFTRFTNDVIANTAFGVSCDSLKERENEFYLMGKEAT
DLKGFWKNIKLLLFFLIPQVFKLCKVRFFSKSVANFFTNLIKGNITKREEFGIVRPDMIYLLMEARKNVS
NEPISDEDITAQALIFFFAGFDTVSSAMCFMSYELATNPEIQEKLLQEIDSVEGKPTYDTLMNLKYLDMV
VSETLRKWPISVATDRICNKPYTIEPKSPDKRPLLLEKNLAVWIPVYALHRDPNYFPDPNRFDPERFNEE
NKANIKPYTYLPFGLGPRNCIGSRFALLEMKILFFYILSHFEITPIPRTQIPLKINKTQFALTAEDGFWL
GLKRRQK

CYP9Z2      Tribolium castaneum 
            GenEMBL XP_975385
            69% to 9Z4
MFWILIVIAAIIAISYHQLRRYHKYWSEKGVQQGDPLPLFGHCLGTTLQKQSLSEFIQMSYNVAPDARYC
GIYQFYSPILIVRDPELIKQITVKDFDHFVNRMAFIPEDCDPLWGKNLVALTDQRWRDMRSTLSPAFTSS
KMKYMFSLISESAEQFAQYFANQDQDLITIEMKDIFTRFTNDVIANTAFGVKIDSLEERNNEFYLMGIEA
TDFRGFWRNMKIVIYFIFPTLFKSLGWRFFSKNVADFFVKLVRDNIAKREKHGIVRPDLINLFLEARKNG
LKYEEQEHALDTGFATAEESEIGKNGMVRQTLTDVDIAAQALLFFFGGFDSVSSMMCFMSYELALNPDVQ
AKLLREVDETFESCDGKLTYEALIKMKYLDMVVSETLRLWPTNVSADRVCTKPYTIEPKNPNEKALHLEK
NTNVIVPIFGIHRDAKNFPEPNRFDPERFSDENKANIRPYTYLPFGAGPRNCIGSRFALLETKALFFHLL
SKFEITPVEQTQIPIQLNRKSFNMTAENGFWLGLKRRKNDN

CYP9Z3      Tribolium castaneum 
            GenEMBL XP_975390
            61% to 9Z1
MIWFSTAVITIIALFYWLLIRPFKHWIKKGVAQGNPVPVFGHLLGTILHKQSFSEMIQTVYNIAPDSRYC
GMYQFFQPMLVLRDPELIKQITVKDFDLFMNHKGFIPPDCEPLMGKVLILLTDQKWKDMRNTLSPAFTSS
KMKYMFGLISESAQRFTGHFSKKNDNVITIEMKDIFSRFTNDVIANTAFGVEIDSLEEPNNEFYLMGLEI
TNFQGVVTFLKFLTFVILPRVAKFLKLTFFSKKVGKFFTKVIKENIANREKHGIVRPDMVNLLLEARKNS
DTQKITDEDITSQAIIFFMGGFDPVSSLMSFMSYELAANPDVQTKLLREIDKTYERCDGKLTYEALVEMK
FMDMVVSETLRLWPANGMTDRVCNTSYIIEPKDSTEKPLRLEKGDVVMVPIFGIQRDPKYFPEPNRFDPE
RFNEENKIKIKPYTYLPFGTGPRNCLGTRLALLETKALFFHLLSTFEIIPVEKTEIPLRLTRKSFNMTAE
NGFWLGLKRRSDKL

CYP9Z4      Tribolium castaneum 
            GenEMBL XP_975395
            69% to 9Z2, 68% to 9Z3
MLWILVSIAIIALSYLFLIRPFKYWTNLGVEQGNPVPVFGHSWGTIVHTQSFADLVQMVYNIAPGARYSG
MYQFFTPTLVLKDPDLIKQIAVKEFDSFLNHRSFIPEDVDPLWSKNLFSLTNQKWRDMRSTLSPAFTSSK
MKYMFVLISESAEQFIGHFLKQKEDVITIEMKDTFTRFTNDVIANTAFGVKIDSLEERNNEFYLMGKEAT
DFKGFWRNLKFLILLSCPTLFKYLGINFFPKAVSSFFRRLVKDNINNREKHGIVRPDMINLLLEARKNVE
ESDIGKNGAIKQKITDDDITAQALLFFFGGFDSVSSLMCFMSYELGINPDVQEKLHQEIDETLEACKGKL
TYEALMKMKYMDMVISETLRLWPTAVASDRLCNKPYTIEPKDPTEKPIHLEKNSVVWIPIFAIHRDPQYF
PEPNRFDPERFSDENKNNINPYAYMPFGVGPRNCIGSRFALLETKALFFHILSKFEIVPIEKTEIPLQLN
RKSFSMTAENGFWFGLKRRESNK

CYP9Z5      Tribolium castaneum 
            GenEMBL XP_975402
            57% to 9Z4
MFWALILAAVLLVTYWLLSRPYKYWTERGVKQGKPVFIFGDYWGPMLRKQTNAEVVDMLYNQIDKEARYC
GIYQFLTPVLLIRDPELIKKITVKDFEHFVDHRIVIPEESDPLSGQKWRDMRSTLSPVFTSSKLKYMFSL
ISERGEQFAQSLLKENKDVITLDIKNSFTRYTNDVMASTMFGITCDSLQEPKNEFYSLAQKSQDFSGFWK
NVKLLGYFLFPEFCKSLEISFYSKEVNSFFEKLVTENIGSRQKHGIVRPDLIHLLMEAKNHAKKSTGYQE
SNKMKTEITDQDIATQALIFFFGGFDTVASLMSFMSYELATNPDCQEKLRQEVDEVMQNCNGKVTYEAIV
NMKYMDMVTSETLRKWPNAPAVDRVCTKPYTIEPARPDEKPIHLKENDTVLLPIYALHRDPKYFPNPDRF
EPERFSEENKANIEPYTYMPFGSGPRNCIGQRFALIETKLFFFYILANFELIPVERTQIPLKLTKNPFTM
TAEKGFWLGFKKR

CYP9Z6      Tribolium castaneum 
            GenEMBL XP_972794
            63% to 9Z7
MFWILVGLALVALYWALSRPHSYWKRKGVVQGSPVFLLGDSWPMLFRKYSPPEMTELFYKASPNTRYFGI
YEFLTPGLLLRDPDLIKQITVKDFDHFVDRRPFVPEKADPLFGKSLFSLKGPKWRAMRSTLSPVFTSSKM
KYMFQLMSQTGERFINHFLNQKEEVVTVEMKEITTKFANDVIGNIVFGYECDSVKDPKNEFYVMGADLTN
FRSLRFLLVFSAKSIFQLFKIPLFPKKVSDFFVRVVNDNIESREKHGIVRPDMIHLLLKMKSNNLKHEEV
ETVPDAGFASVEESELGKNAKTVTKITNEDIAAQALLFFFAGFDSVSSLISYMAYELAVNPDVQTKLLQE
VDETRQKSDGKITYEALMSMKYMDMVVSEALRKWPNAIATERVCTKPYTIEPKLPDEKPLRLEIGDVVAI
PMYAIQRDPKYFPEPERFIPERFSDENKSKVQPYTFMSFGTGPRSCIGSRFALLETKLLFYYFLTNFEFV
PVEKTQIPIKFNRKALNMSPENGFWLGLKRRV

CYP9Z7      Tribolium castaneum 
            GenEMBL XP_972840
            63% to 9Z6
MLLVLLAIATLIYFYWKIIYPHKYWTRKGVPQSKPVFLFGDIWPMIIRKYSAPELVDEFYKIDQNARYCG
VYQFLSPGLILRDPELIKEITVKDFDHFVDRRVFVKENVDPVFGRSLLSLDGEKWRNMRAAVSPVFTSSK
MKYMFPSISQCGEDFANYFLKQNKDLLELEMKESITKFTNDVIANTVFGFTCNSLENPNNEFYKMGDEVG
NMTSMRTRIVFLMNALAPKILSFFKIYLFSPRIYTFFRQVVNENISSREKHGVTRPDMIDLLVKAKNNSL
KNEEADDLPEAGFTTVKDTENGKKSRKYQITDEDIVAQALLFFFAGFDSVAGVISYMCYELAVAQDAQEK
LRQEVDETREKCGGKISYEELMKMKYMHMAVSETLRKWPTAIASDRVCVKPYTIQPKLPNEKPLHLKVGD
TVNIPIYAIQRDPQYFPEPDRFIPERFSEENKSKIVPYTYMSFGTGPRSCIGYRFALLEMKILMYHLISN
FEIVPVAKTQIPIRFNPKAVNMTAEKGFWVGLKRRVKV

CYP9Z8      Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9E25017
            63 amino acids from heme to end
            65% to 9V1, 54% to 9E2, 78% to CYP9Z2 = XP_975385

CYP9Z9      Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9E22146
            62 amino acids from heme to end
            66% to 9V1, 58% to 9R1, 77% to CYP9Z2, 93% to 9Z8 (4 aa diffs)

CYP9Z10     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9J12446
            64 amino acids from heme to end
            67% to 9V1, 61% to 9A19, 73% to CYP9Z2, 88% to 9Z9, 87% to 9Z8

CYP9Z11     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V2046
            64 amino acids from heme to end
            64% to 9V1, 60% to 9R1, 85% to 9Z8
            74% to 9Z2 = XP_975385

CYP9Z12v1   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V1433
            66 amino acids from heme to end
            64% to 9A19, 62% to 9V1, 96% to CYP9Z12v2 (1 aa diff)
            69% to CYP9Z2 = XP_975385

CYP9Z12v2   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V1103RRB3
            66 amino acids from heme to end
            62% to 9V1, 62% to 9A19, 77% to 9Z14v1
            67% to CYP9Z2 = XP_975385

CYP9Z13     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V44c61
            66 amino acids from heme to end
            62% to 9V1, 61% to 9A19, 59% to 9E2, 
            69% to CYP9Z3 = XP_975390, 78% to 9Z14v1

CYP9Z14v1   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V1like273r42
            136 amino acids from EXXR to end
            61% to 9V1, 57% to 9D1, 57% to 9E2, 
            69% to 9Z2 = XP_975385
            98% to CYP9Z14v2 (2 aa diffs), 97% to CYP9Z14v3 (3 aa diffs)

CYP9Z14v2   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V1043
            136 amino acids from EXXR to end
            60% to 9V1, 53% to 9A19, 68% to 9Z2 = XP_975385

CYP9Z14v3   Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P9V1153
            136 amino acids from EXXR to end
            61% to 9V1, 58% to 9E2, 68% to 9Z2 = XP_975385

CYP9Z15     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P941121
            64 amino acids from heme to end
            56% to 9V1, 56% to 9a20, 55% to 9G3, 64% to 9Z10
            62% to 9Z1 = XP_975381, 65% to 9Z4

CYP9Z16     Leptinotarsa decemlineata (Colorado potato beetle)
            No accession number
            Jianhua Zhang
            Submitted to nomenclature committee April 2, 2006
            Clone name P945125
            73 amino acids from heme to end
            53% to 9V1, 48% to 9a20, 46% to 9E2 
            56% to 9Z2 = XP_975385, 66% to 9Z8

CYP9Z17     Ips pini (pine engraver, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            61% to 9Z14 Colorado potato beetle (C-term piece), 55% to 9Z18
            clone name EST 9D04

CYP9Z18     Dendroctonus ponderosae (mountain pine beetle, bark beetle)
            No accession number
            Pamela Sandstrom
            Submitted to nomenclature committee on April 26, 2006
            Full length sequence
            55% to 9Z17
            clone name EST MPB1G10

CYP9Z18    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           Clone name DPO1028_G02

CYP9Z18     Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP9J-2
            93% to CYP9Z18 Dendroctonus ponderosae DPO1028_G02 probable ortholog
            57% to CYP9Z20v1

CYP9Z19    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           57% to CYP9Z18
           50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO1029_P08

CYP9Z20    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           57% to CYP9Z18
           59% to DPO1029_P08, 59% to DPO1017_C19
           58% to DPO111_E18, 57%  to DPO1028_G02
           56% to DPO1119_I16, 58% to DPO1021_H21
           54% to CYP9Z2, 53% to CYP9Z4, 
           50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO042_F03

CYP9Z20v1   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP9RH1-1
            94% to CYP9Z20 Dendroctonus ponderosae (probable ortholog) 
            98% to CYP9Z20v2

CYP9Z20v2   Dendroctonus rhizophagus
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee May 20, 2010
            Clone name CYP9RH1-2
            94% to CYP9Z20 Dendroctonus ponderosae (probable ortholog) 
            98% to CYP9Z20v1

CYP9Z20v3   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP9J-1
            99% to CYP9Z20v4
            98% to CYP9Z20v2

CYP9Z20v4   Dendroctonus valens
            No accession number
            Claudia Cano Ramirez
            Submitted to nomenclature committee June 8, 2010
            Clone name CYP9J-2
            97% to CYP9Z20v2

CYP9Z21    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           54% to CYP9Z18
           51% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO1119_I16

CYP9Z22    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           55% to CYP9Z18
           49% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO1021_H21

CYP9Z23    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           54% to CYP9Z18
           50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO111_E18

CYP9Z24    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           54% to CYP9Z18
           50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO1017_C19

CYP9Z25    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z26    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z27    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z28    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z29    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z30    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z31    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011

CYP9Z32    Rhynchophorus ferrugineus (red palm weevil)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Jan. 26, 2012
           55% to CYP9Z25 Leptinotarsa decemlineata
           missing N- and C-terminals

CYP9Z33    Rhynchophorus ferrugineus (red palm weevil)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Jan. 26, 2012
           60% to CYP9Z20 Dendroctonus ponderosae
           missing N- and C-terminals

CYP9Z34     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            95% to CYP9Z23 Dendroctonus ponderosae

CYP9Z35     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            91% to CYP9Z21 Dendroctonus ponderosae

CYP9Z36     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            93% to CYP9Z19 Dendroctonus ponderosae

CYP9Z37     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            79% to CYP9Z19 Dendroctonus ponderosae

CYP9Z38     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            80% to CYP9Z22 Dendroctonus ponderosae

CYP9Z fragment    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Shi Xiaoqin 
           Submitted to nomenclature committee Dec. 10, 2010 
           CYP3 clan
           Clone name seq 46
           60% to CYP9Z4 Tribolium
           short internal seq, probably belongs to CYP9Z8-9Z16 C-terms
           
CYP9AA1     Tribolium castaneum 
            GenEMBL XP_972755
            52% to 9Z5
MWWLLIAAFTLLYALYIRLKKKNEYWIKKGVKQGSPVLIFGDKWRAIAHNESLADMVQKIYNVGPGDRYC
GAYDFMSPALVLKDPELIKDILVKDFDHFVDHKRVIPEGSDPIWDKNLFFLTGQKWRDMRSTLSPVFTGS
KMRFMFNLIAKSADQFVQHFVKQEETLIQIEMKDACARLTNDIIASTVFGFESDSVEDPDSKFYEMARKI
TDFSGLWQGLKILGFFIFPKYFENQNLSTEISNFFYNIVKENIRSRQLQNISRPDMISLLMEARENHKLI
HGVEISDEDVTAQALVFFFAGFDSVSSLMTFMSYELALNPEIQKKLIEEIDTTTKTLDYDVVKSMKYLDM
VVSETLRKWPITPFVNRVCTIPYTVQPKRPDENPIHLKKDAIVFLPIYGLHHDPKYFKDPERFDPERFSD
ENKAKIVPYTYVPFGAGPRKCIGYRFALLEIKILFFFLLSKFEIVTVDRTEIPVKICKKALNMTPEGGLW
LGLKPRK

CYP9AB1     Tribolium castaneum 
            GenEMBL XP_972546
            51% to 9Z4
MWWFFVLLLGAPIVFFIFLYRTQKHWERRGLKQKNMGVTIPDNWAETKYPITFPDYVQKFYEMFPNRRYV
GYYTISNPSLFIRDLDLIKQIIVKDFEYFTDHQHFIWEENDPLWSQNLFSLKGKKWREMRTTLSPTFTSS
KIKYMFTLVQKNGEQFARYFLDKNENFMVFEMKDIFTRFTNDVIASSAFGVECDSLREPQNEFYLMSKAV
TDFTGLWKIVAGTFYFLMPSVAKFLNISLFPKKGSKFFSNLVKSNIKSRLQHGIVRPDMINIMLEARKHG
LKHEETQPSQDTGFATIEESELGKSGKVKKEITDDDITSQALVFIFAGFETVSSMMCFLSYELALNPDIQ
KRLIQEIDQTLDACGGSITYESLMGMKYLDMVLTESLRKWPISAGLDRVCTKEYVIEPKLPGENPVRVDK
GTTILVPVYALLRDPKYFPNPEKFDPERFSDENKGKIVPYTFLPFGAGPRSCIGTRFAIMETKVLFFSIL
RHFEIVRVEKTAVPIRYIPQQITLSSADGFWLGFKRRVKV

CYP9AC1     Tribolium castaneum 
            GenEMBL XP_969007
            50% to 9Z2
MINMNYMITKHNKEQKNHGNKIQQHRKRITGTIYLGIFCAIFGYFYYYVKRQQNVWHQKGIKYCKPKFLL
GSLEIIRSKSLAQIIQELYNAFPEERYHGFYQFLLPTLIIKDPDLIKQITIKDFDHFVNHRRFVNADDDP
FWSRNLRGILVFARRDEKWRDMRATLSPSFTSSKMRIMFELMDECAREFVQHFKSQNSDTVELEMKDTLR
RFTNDVIASTAFGLKINSLKDRKNEFLLMGAAATDFGYIRTMKFLLYTLSPKLCQLLKMKIIPTKVADFF
TVIIKDTIKKRKEKNIIRPDMIHLLLEAQKGRQHPEEHLDIDEGFSSVSESKLTKPNEKLEITTEDIISQ
ALIFFLAGFDTVSTLLNFLFYELAVNPDVQTRLRTEIQSVDEKITYETLLKLKYLDMVMSEALRKWPPAI
ATDREVAKNYTIEPTKPDEKPLLLEEGMLCSIPICAIHRDEKYYPEPEKFDPERFNDENKHKINPLTFIP
FGAGPRNCIGSRFALLESKLLVFHVVKNFEIVPIDKTLIPLVMDKYQINWSVKGGTWLGLKNI

CYP9AD1     Tribolium castaneum 
            GenEMBL XP_973619
            49% to 9Z2, gene model shortened at N-term
MLLLLLGTLIVILVLYLVNLSTKNFDHWEKRRVKYVKPFPFVGNLLPTVLKTKSTA
ELIQHLYKAFPNERFVGIFQFNTPILLIRDPELIKSIAIKNFDNFVDHYGFANDDIDPLWAKNLFASQGE
RWRDLRQTLSPVFTSSKMRTMFVLMDECVKQLTEYFKDQKQDVIDIELKDIFSRYTTDVIATTAFGIKVD
SLRNRNNDFVVSGREFTDFSGLRGLAFFINGSYPRLAKFLNIKIVSDRLGNFFRTIIKETLTLREEKKIV
RPDLIHSLMLARKGKLKYEELMELPEAGFAAVEESNLTKSNNNVNFLTDEDITAQALVFFLGGFDTTSSL
MCFAGYELAINPHIQKRLKDEVLATDRECNGQITYEKLLNMKYLDMVVSETLRKWNQAVWLDRKCTKEIE
IESETSGEPSVTLKVGDIIWMPAYAIHHDPKYYPNPELFDPERFSDENKDKIRTGTYLPFGVGPRNCIGS
RFALLETKLLLYNLLLNFDLVTNHKTENPIKLRRDTPLLMPQNGFQVSLRKNDAFSEK

CYP9AE1     Aedes aegypti

CYP9AF1     Tribolium castaneum 
            GenEMBL XP_972495, AAJJ01001543.1
            56% to 9Z14 (potato beetle C-term fragment)
            46% to 9D4
            deletion in mid region
MLLSLFAVFLSVLIFFKFVSPCTYWKEKGVKHAQAWPFIGSMGRVFFKKQPYVEFLTELYNKFPNER (2)
YVGFMKFTQNHILIRDIELIGKITGKEFNFFTDRTVSSRLRKDKILSQSLISLTGDHWRD
MRATLSPAFTSNRTRNLYTFIETCARNFVNHYKAEVEIEVKEVFAKFANDVIASVAFSTELNSLKEPNDFYTN
ASQLKPDFFKQFI
TTSDKNRQDLISLLKDESLKFETYKRAKGEGFAIGEEPQIDPLSRKIQLTDEQI
LAQALLFFLTGFETISTSASFLAYELAVNLDVQKKLQREIDKVVQITGDRIPYDALLSMKYLDQVISESL
17091 RKWPPKFETDRVCTRDYHIKAQKGEKSLLIRKGMSVVIPIMAIHRDPDYYPNPNRFDPERFSDENRDKVV
PGTYLPFGAGPRNCI (1)
GARLALLEMKTVFGYLLAKFDIVQAKKTQMPIKLSAKCLDMEPEEGFWLGFRPRN 17561

CYP9AG1    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG2    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG3    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG6    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG7    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AG8P   Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH1    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH2    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH3    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH4    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH4-de1b    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH5    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH6    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AH7    Nasonia vitripennis (jewel wasp)
           See wasp page

CYP9AJ1    Bombyx mori (silkworm)
           no accession number
           see silkworm page for details

CYP9AJ1    Antheraea mylitta (wild silkmoth) from fat body
           EB742536.1
           76% to CYP9AJ1
           renamed as an ortholog, formerly CYPCYP9AJ2
RYFGLYQYLVPTLVPRDPELIRQIMVRDFHAFADRGVHISADCDPLFGRNLIMLT
GSNWRSMRVSLSPAFSGARCRCMAPLMADTARAVAQHLKHHITHEQLIDINT
ITMAYVNDVIASCAFGFAVNSLEDLQ
NGIFRLGQRAIVQDTT

CYP9AJ1     Helicoverpa armigera (cotton bollworm)
            No accession number
            Heiko Vogel 
            submitted to nomenclature committee Feb. 6, 2008
            Contig_190 69% to CYP9AJ1, 39% to CYP9P22
            HAH015123 1 aa diff to Contig_190
            renamed as an ortholog, formerly CYPCYP9AJ3

CYP9AJ1v1  Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012
           renamed as an ortholog, formerly CYPCYP9AJ4v1

CYP9AJ1v2  Lymantaria dispar (Asian gypsy moth)
           No accession number
           Chuanwang Cao
           Submitted to nomenclature committee Oct. 17, 2012
           renamed as an ortholog, formerly CYPCYP9AJ4v2

CYP9AK1    Lucilia cuprina (Australian blowfly)
           No accession number
           Zhenzhong Chen
           Submitted to nomenclature committee on Dec. 18, 2007
           Clone name Luce0072E07 
           51% identical to Dm CYP9f2
           153 aa at C-term

CYP9AL1    Culex pipiens

CYP9AM1    Culex pipiens

CYP9AN1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           49% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO0410_B16

CYP9AP1    Dendroctonus ponderosae (mountain pine beetle, bark beetle)
           No accession number
           Christopher I. Keeling
           Submitted to nomenclature committee Oct. 21, 2009
           44% to CYP9Z4
           41% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
           clone name DPO1319_O05

CYP9AQ1     Locusta migratoria manilensis
            No accession number
            Rongrong Yu
            Submitted to nomenclature committee Dec. 12, 2010
            49% to CYP9E1 Diploptera punctata

CYP9AQ2    Locusta migratoria manilensis
           No accession number
           Yanqiong Guo
           Submitted to nomenclature committee Aug. 17, 2011
           61% to CYP9AQ1 Locusta migratoria

CYP9AR1    Pediculus humanus humanus (body louse)

CYP9AR2    Pediculus humanus humanus (body louse)

CYP9AS1    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS2    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS3    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS4    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS5    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS6    Linepithema humile (argentine ant)
           No accession number
           

CYP9AS7P   Linepithema humile (argentine ant)
           No accession number
           
CYP9AS8    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS9    Linepithema humile (argentine ant)
           No accession number
           
CYP9AS10P  Linepithema humile (argentine ant)
           No accession number
           
CYP9AS11v1 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP9AS1 Linepithema humile

CYP9AS11v2 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           70% to CYP9AS1 Linepithema humile

CYP9AS12Pv1 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           50% to CYP9AS6 Linepithema humile

CYP9AS12Pv2 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           49% to CYP9AS4 Linepithema humile

CYP9AS13v1 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           67% to CYP9AS8 Linepithema humile

CYP9AS13v2 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           67% to CYP9AS5 Linepithema humile

CYP9AS14v1 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           69% to CYP9AS5 Linepithema humile

CYP9AS14v2 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           69% to CYP9AS5 Linepithema humile

CYP9AS14v3 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           69% to CYP9AS5 Linepithema humile

CYP9AS15Pv1 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           60% to CYP9AS8 Linepithema humile

CYP9AS15Pv2 Pogonomyrmex barbatus (seed-harvester ant)
           See Pogonomyrmex page
           Reed Johnson 
           Submitted to nomenclature committee June 3, 2010
           64% to CYP9AS8 Linepithema humile

CYP9AT1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           48% to CYP9J16 Aedes aegypti

CYP9AT2    Chironomus riparius(aquatic midge)
           No accession number
           Jinhee Choi
           Submitted to nomenclature committee Dec. 1, 2011
           55% to CYP9AT1 Chironomus tentans

CYP9AU1    Chironomus tentans (aquatic midge)
           No accession number
           Kun Yan Zhu
           Submitted to nomenclature committee May 31, 2011
           42% to CYP9J24 Aedes aegypti

CYP9AV1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Fang Zhu
           Submitted to nomenclature committee May 26, 2011
           46% to CYP9Z17

CYP9AV1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee Dec. 26, 2011
           100% to CYP9AV1
           complete seq.

CYP9AW1    Agrilus (Emerald ash borer)
           No accession number
           Praveen Mamidala
           Submitted to nomenclature committee Nov. 10, 2011
           49% to CYP9Z4 Tribolium

CYP9AX1    Coptotermes formosanus (termite)
           GenEMBL JN969113 (March 2012)
           Qinggang Xu
           Submitted to nomenclature committee Nov. 22, 2011
           51% to CYP9E2 Blatella germanica
  
CYP9AY1    Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Jia Shuang
           Submitted to nomenclature committee Dec. 26, 2011
           46% to CYP9Z2 Tribolium
           nearly complete seq.

CYP9AZ1     Dentroctonus ponderosae (mountain pine beetle)
            No accession number
            Christopher I. Keeling
            Submitted to nomenclature committee March 30, 2012
            50% to CYP9Z19 Dendroctonus ponderosae

CYP9 fragment?   Leptinotarsa decemlineata (Colorado potato beetle)
           No accession number
           Liu Ping 
           Submitted to nomenclature committee June 10, 2010 
           CYP3 clan
           Clone name P-9
           53% to CYP9P5 Nasonia, 53% to 9J7 Aedes aegypti
           52% to CYP6DB2 whitefly Trialeurodes vaporariorum
           Too short to name yet.