41 CHICKEN SEQS. 21 are full length

NOT FOUND 2B, 2E, 2F, 2S (probably mammal specific subfamilies)

8A, 21, 27B (probably rare transcripts)

The yellow regions were found by students in a bioinformatcs class MSCI814 at UT

 

>CYP1A5 Gga.617 found by Leslie Hunt, Michael Mohler, Wei Liu

MGPEEVMVQASSPGLISATEVLVAAATFCLLLLLTQTRRQHAPK

GLRSPPGPRGLPMLGSVLELRKDPHLVLTRLSRKYGDVMEVTIGSRPVVVLSGLETIK

QALVRQAEDFMGRPDLYSFRHITDGQSLTFSTDTGEMWKARRKLAQNALKNFSIAASP

TASSSCLLEEHVSTEASYLVTKFLQLMEEKQSFDPYRYMVVSVANVICAICFGKRYDH

DDQELLSVVNVVDEFVDVTAAGNPADFIPLLRYLPSRNMDSFLDFNKRFMKLLQTAVE

EHYQTFDKNNIRDVTDSLIEQCVEKKAEANGATQIPNEKIINLVNDIFGAGFDTVTTA

LSWSLMYLVTYPHMQKKIQAELDQTIGRERRPRLSDRGMLPYTEAFILEMFRHSSFMP

FTIPHSTTRDTVLNGYYIPKDRCVFINQWQVNHDEKLWKDPQAFNPERFLNAEGTEVN

KVDAEKVMTFGLGKRRCIGENIGKWEVFLFLSTLLQQLEFSIQDGKKADMTPIYGLSM

KHKRCEHFQVKKRFSMKSSN

 

>CYP1A4 Gga.618

MAAGPQAAMEQASSPGLISATEVLVAAATFCLLLLLTQTRRQHA

PKGLRSPPGPRGLPMLGNVLELRKDPHLVLTRLSRKYGDVMEVTIGSRPVVVLSGLET

IKQALVRQAEDFMGRPDLPSWQYVSNGHSLAFSYECGDAWKARRKLAQNALKTFSIAA

SPTASSSCLLEEHVSTEASYLVTKFLQLMEEKQSFNPNSYLMVSVANVICAICFGKRY

DHDDQELLSVVNMNTEFGDVAAAGNPADFIPLLRYLPNRAMAAFKDVNARFSAFVQKI

VQNHYSTFDKEHIRDVTDSLIGHCQEKRTGEDVRVQPSDESIISIVNDLFGAGFDTVT

TALSWCMMYAALYPHIQKKIQAELDQTIGRERRPRLSDRGMLPYTEAFILEAFRHSSL

LPFTIPHCTTKDTVLNGYYIPKDTCVFINQWQANHDEKIWKDPPSFKPERFLNAAGTE

LSRTEADKVLIFGLGKRRCIGESIGRWEVFLFLTTILQQLEISLAPGQRVDITPQYGL

TMKYKQCECFQMKKRFPSKGSA

 

>CYP1B1 72% to human found by Ajit Narang BU113337 BU290505 BU315485

SRDMMDAFIRLQREQPRLQLEHVPATVTDIFGASQDTLSTALLWLLIFLIRY

PKVQAKMQEEVDRIVGRDRLPCAEDQPHLPYIVAFLYESMRFSSFVPVTIPHATTTNTFI

MGYLIPKDTVIFVNQWSVNHDPAKWSNPEDFDPTRFLDENGFINKDLTSSVMIFSMGKRR

CIGEELSKVQLFLFTSILVHQCHFTANPNEDPKMDYTYGLTIKPKPFTLNVTLRDTMELL

DKAVQRLQAEKTANEN*

 

>CYP1B LIKE CC285424 Gallus gallus genomic clone Length = 1161

C-TERM EXON 86% TO CYP1B1 CHICKEN

TMGNRWCIERELYKVQLFVFTSILVHQCHFTANPNE

DLKMDYTYGLTIKRKPFTLNVTLRDSMELLDKAVQRLQAEKTGNEN*

 

>BU263491 59% to 1C2

RNDRFGQTVGAGSLVDVLPWLLRFPNPVRHVYRDFQALNRELHGFVQAKVAQHRQTFDWR

AVRDISDVMIASVERGGGSPDGLGPEDVEGAMTDIFGAGQDTTSTALSWIILLLLKHPQV

QQDLQAELDRVVGRSRLPTAEDRPHLPLLEAFIYETLRYSSFVPITIPHATTADVELEGF

RIPKGTVVFVNQWSVNHDCSKWPEPQRFDPTRFLDKQQRLDRERAGSVMIFSAGQRRCIG

DQLSKLQIFLFTXILLHQCSFHANPAEHLTMDCIHGAGAEATAFHRQRAAEGSPG

 

>M64537.1 Gallus gallus cytochrome P450 (CYPIA-2) mRNA, partial cds.

66% to 1A5 PIY to end 100% match PNE to LVT 100% match

53% to 1A4

KFLQIAVEEHYQSFDKNNIRDVTDSLWRSKKTKPRGAAD

PNEKIINLVNDIFGAGFDTVTTALSWSLMYLVTQPHSQKKIQESELDTAIGRERRSWLSERSM

LPYKEAFILETVPTWQFVPFTIPHSTTRDTTLNGFHIPKECCVFVNQWQVNHEAELWE

DPFVFRTERFLTDDSTAIDKTLSEKVMGKQVGLAWKSALGTRQWEVSFYLSTLTPNWS

SAPGGESKKDRVRPIYGLSMKHKRCEHFQVKKRFSMKSSN*

 

>CYP2G like BU386444 BX260862 BG711105 BI391656 BX273337 BU249330

57% to 2G1 rat and 57% to 2G2P human found by M. Nooh

MEVTAALLLFLGLSLVVLLAVRGRGGSGGGGRLPPGPTPLPLIGNLLQISPSQTLK

SLLKLRDKYGPVFTVYLGTRRVVVLCGHEAVHEALVGHAEEFAGRGRMPTV

ERTFHGHGVVFANGERWKQLRRFSLTVLRDFGMGRHSLEGPIQEEAQCLVQEMRNTQGKP

FDPTYMLSRAVSNIICAMVFGKRFDYNDAELLELLQMMNESFREISTPAAQLYEMSETLL

QYFPGPQDKIYALLESMRSFIARRVRCNAQSLEPSNPRDFIDCFLLQME

KEKNNPNSEFTMENLELTALNLFFAGTETISSTLRYAFVLLMKNPSVLEKVHAEIDAVIG

 

>CYP2C45    gallus gallus (chicken) AJ430584 AJ430583

found by Fei Cao, Jie Shen, Lei Yang, Senhua Yu, Stephanie Nance, Y. Zhuang, Yi Jin

MLLLGAASVVLLVCVACLLSIVQWRKRTGKGKMPEGPTPLPIVG

NILEVKPKNLAKTLEKLAEKYGPVFSVQLGSTPVVVLSGYEAVKEALIDRADEFAARG

HMPIGDRANKGLGIIFSNNEGWLHVRRFALSTLRNFGMGKRSIEERIQEEAEHLLEEI

TKTKRLPFDPTFKLSCAVSNVICSIVFGKRYDYKDKKFLSLMNNMNNTFEMMNSRWGQ

LYQMFSYVLDYLPGPHNNIFKEIDAVKAFVAEEVKLHQASLDPSAPQDFIDCFLSKMQ

EEKDNPKSHFHMTNLITSTFDLFIAGTETTSTTTRYGLLLLLKYPKIQEKVQEEIDRV

VGRSRRPCVADRTQMPYTDAVVHEIQRFITLIPTSLPHAVTKDIHFRDYIIPKGTTVM

PLLSTALYDSKEFPNPTEFNPGHFLNQNGTFRKSDFFIPFSAGKRICPGEGLARMEIF

LLLTAILQNFTLKPVISPEELSITPTLSGTGNVPPYYQLCAIPR

 

>CYP2D49   Gallus gallus (chicken)

           chr1:46131304-46140141

           ENSGALT00000019412.2

MTLLLWLSSWSNISVLGVFLTVFTILVDFMKRRKKWSRYPPGPMPLPFVG

TMPYVNYYNPHLSFEKFRKKFGNIFSLQNCWTNVVVLNGYKTVKEALVNK

SEDFADRPYMPVYEHLGYGHKSEGLVLARYGHLWKELRKFTLTTLRNFGM

GKKSLEERVTEEAGFLCSAISSEGGHPFDPRFLVNNAVCNVICTITYGER

FDYGDKTFKKLLTLFENSLNEEAGFLPQLLNVAPVLLRIPGLPQKIFPCQ

KAYVDFTQMLIDKHKETWNPAYIRDFTDAFLKEMAKGKEAEENGFNKSNL

TLVTADLLVAGSETTATTLRWAFLFMLLYPEIQSKVHKEIDKVIGRNRPP

TMADQVNMPYTNAVIHEVQRFGDVVPMGLPHMTYRDTELQGFFIPKGTTI

ITNLTSVLKDETAWKKPNEFYPEHFLNENGQFVRPEAFLPFSAGRRACLG

EQLTRMELFIFFTTLMQKFTFVFPEDQPRPREDSHFAFTNSPHPYQLRAV

PSITQDQGK

 

>CYP2H1      chicken PIR P05180 55% to 2C8 found by Senhua Yu

  1 MDFLGLPTIL LLVCISCLLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP WDLMGSFKEL

 61 SKKYGPIFTI HLGPKKIVVL YGYDIVKEAL IDNGEAFSGR GILPLIEKLF KGTGIVTSNG

121 ETWRQLRRFA LTTLRDFGMG KKGIEERIQE EAHFLVERIR KTHEEPFNPG KFLIHAVANI

181 ICSIVFGDRF DYEDKKFLDL IEMLEENNKY QNRIQTLLYN FFPTILDSLP GPHKTLIKNT

241 ETVDDFIKEI VIAHQESFDA SCPRDFIDAF INKMEQEKEN SYFTVESLTR TTLDLFLAGT

301 GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD AVIHEIQRFI

361 DFLPLNVPHA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK EFPNPEKFDP GHFLNANGTF

421 RRSDYFMPFS AGKRICAGEG LARMEIFLFL TSILQNFSLK PVKDRKDIDI SPIITSLANM

481 PRPYEVSFIP R

 

>CYP2H2 chicken PIR P20678 57% to 2C18 Gga.802 Links M25469.1 phenobarbital-inducible

found by Senhua Yu

  1 MDFLGLPTIL LLVCISCFLI AAWRSTSQRG KEPPGPTPIP IIGNVFQLNP WDLMESFKEL

 61 SKKYGPIFTI HLGPKKVVVL YGYDVVKEAL IDNGEAFSGR GNLPLFEKVF KGTGIVTSNG

121 ESWRQMRRFA LTTLRDFGMG KKSIEERIQE EARFLVERIR NTHEKPFNPT VFLMHAVSNI

181 ICSTVFGDRF DYEDKKFLDL IEMLDENERY QNRIQTQLYN FFPTILDYLP GPHKTLIKSI

241 ETVDDFITEI IRAHQESFDA SCPRDFIDAF INKMQQEKEN SYFTVESLTR TTLDLFLAGT

301 GTTSTTLRYG LLILLKHPEI EEKMHKEIDR VVGRDRSPCM ADRSQLPYTD AVIHEIQRFI

361 DFLPVNLPRA VIKDTKLRDY FIPKDTMIFP LLSPILQDCK EFPNPEKFDP GHFLNANGTF

421 RKSNYFMPFS AGKRICAGEG LARMELFLFL TSILQNFSLK PVKDRKDIDI SPIVTSAANI

481 PRPYEVSFIP R

 

chicken NW_060416.1|Gga8_WGA225_1 five CYP2J sequences chromosome 8

 

>CYP2J24P

15504220    DSMKRQWLNFFKSIVGQQQLHCADYMKRRKPKDFPPSPFSFPFLGNV*FMFAKDPVVATQK  15504038

15503534  IIEEHGDIFSMQVGTQSFVIVNGLPLIKEALVTQGENFMDRPEIPMNAEVFSKL  15503385

15503168  GLLSSNGHL*KQQRRFTLTTL*NLGLGKRSLEERIQKECQFLTDAFRDEQ  15503019

15501515  GNPFNPHLKVNNAVSNVICSITFGNWFEYHDKDFQNLLQLMDETATFYGKIMNQ  15501354

gap

15501024  PNGSDFCGDNLVLCTLDLFFAGTETTSTTIRWALLFMAIYPEIQ  15500893

gap

15498733  GKRACLGELLARVEIFLFFTSLLQKFTFQAPPDTILDVKFTMGITLAPQPYKICAVPR  15498560

 

>CYP2J23

15510424  MLRFLWDSISLQMLFVFLLVFLLVSDYMKRRKPKDFPPSPFSFPFLGNVQFMFAKDPVVATQK  15510236

15509668  XXEKLGDIFSMQAGSQSFVIVNGLPLIKEALVTQGENFMDRPEIPLDTDIFSKL  15509519

15509300  GLISSSGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTEAFRDEQ  15509151

15508915  GNPFNPHLKINNAVSNIICSVTFGNRFEYHDENFQTLLRLMDETVTLHEKIMSQ  15508754

15508232  LYNAFPSIVKYLPGSHQTIFKNWRLMKDFVNEKISKHKEDLNPSESRDFIDSYLQEMAK  15508056

15507812  PSGSEFHEENLVACALDLLFAGTETTSTTIRWALLFMAVYPEIQ  15507681

15507221  AHVQAEIDAVIGQARQPALEDRNNMPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFRVPK  15507033

15506561  GTILIPNLSSVMYDKKEWETPHSFNPGHFLKDGQFWKREAFMPFSI  15506424

15505718  GKRACLGELLARAELFLFFTSLLQKFTFQAPPDTILDFKFTMGITLAPRPYKICAVPR  15505545

 

>CYP2J22

15518269  MLRFLWDSISLQMLFVFLLVFLLVSDYMKKRKPKDFPPGPFALPFLGNVQLMVAKDPVSTVQK  15518081

15517552  XXEKHGDIFSMQVGSMSFVIVNGLQMIKEALVTQGENFMDRPEFPMNAEVFNKF  15517403

15517205  GLLSSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ  15517056

15515960  GNPFNPHLKINNAVSNVICSITFGNRFEYHDEDFQNLLRLMDETVTLHGKIMSQ  15515799

15514587  LYTFFPSIVKYLPGSHQTVIKNGKLMKDFVCNVISKHKEDLNPSESRDFIDSYLQEMAK  15514411

15514166  PDSSDFCEDNLVSCTLDLFFAGTETTSTTIRWALLFMAMYPEIQ  15514035

15513576  ARVQAEIDAVIGQARQPSLEDRNNMPYTNAVIHEVQRKGNIIPFNALRLTVKDTVLAGFRVSK  15513388

15512873  GTILIPNLSSVMYDKKEWETPHSFNPGHFLKDGQFWKREAFMPFSI  15512736

15512011  GKRACLGELLARAELFLFFTSLLQKFTFQAPPDTILDFKFTMGITLAPRPYKICAVPR  15511838

 

>CYP2J21

15526022  MLRFLWDSISLQMLFVFLLVFLLVSDYMKKRKPKDFPPGPFSFPFLGNMEFIIAKDPVAVTEK  15525834

15525310  FIEKHGDIFSTQVGSMSFVIVNGLPLIKEALVTQGENFMDRPEFPINTEFLNKF

15524941  GLVFSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ  15524792

15523650  GNPFNPHLKVNNAVSNIICSVTFGNRFEYHDEDFQNLLRLMDETVTLQGEPMSQ  15523489

15522627  LYAFFPSIIKYFPGSHQTVLKNEKLMKRFVCKKISKHKEDLSPSESRDFIDSYLQEMAK  15522451

15522209  KPNGSDFCEDNMVSCTLDLFFAGTETTSTTIRWALLYMAIYPEIQ  15522075

15521605  ARVQAEIDAVIGQARQPSLEDRSNMPYTNAVIHEVQRKGNIIPFNXXXXXXXXXXXXXXXXXX  15521471

15521289  XXLLIPNLSSVMSYKKQWETPHSFNPGHFLKDGQFWNREAFMPFSI  15521158

15520424  GKRACLGELLARAELFLFFTSLLQKFTFQAPPDTILDLKFTVGITLAPQPYKICAVPR  15520251

 

>CYP2J20 continued joined by EST BI064782.1| first 3 exons from NW_060417.1

   1641   MLRFLWDSISLQMLFIFLLVFLLVSDYMKRRKPKDFPPGPFSFPFLGNVQFMFAKDPVVAIQK  1453

    943   FIEKHGDIFRTQVGSMSFVIVNGLPLIKEALVTQGENFMDRPEFPTNTEFFNKF  782

    574   GLVSSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ  425

          GNPFNPHLKVNNAVSNIICSVTFGNRFEYHDEDFQNLLRLMNETAILQGKIMSQ

15531671  LYNFFPSVIKYFPGSHQTVIKNGRLMKRFVCKKISKHKEDLSPSESRDFIDSYLQEMAK  15531495

15531239  PNGRDFCEDNLVACTLDLFFAGTETTSTTIRWALLYMAIYPEIQ  15531108

15530636  ARVQAEIDAVIGQARQPSLEDRSNMPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFRVPK  15530448

15529975  GTILIPNLSSVMFDMKEWETPHSFNPGHFLKDGQFWKREAFMPFSI  15529838

15529096  GKRACLGELLARAELFLFFTALLQKFTFQAPPDTILDLKFTHGMTLAPQPYMICAVPR  15528923

 

>CYP2J20 NW_060417.1|Gga8_WGA226_1  Gallus gallus chromosome 8 genomic contig,

may jojn with last seq on upper contig

1641  MLRFLWDSISLQMLFIFLLVFLLVSDYMKRRKPKDFPPGPFSFPFLGNVQFMFAKDPVVAIQK  1453

943   FIEKHGDIFRTQVGSMSFVIVNGLPLIKEALVTQGENFMDRPEFPTNTEFFNKF  782

574   GLVSSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQ  425

 

>CYP2J19 Gallus gallus NW_060417.1weakly like a CYP2J, 52% to 2J2 human 

BI390850.1 EST all the best hits are CYP2Js

12644 MDFRFWPISQLGKLNVSMLLVVLVMFLLIIDFVRKRRPRNFPPGPQLFPLVGTIVDLRQPLHLEMQK  12444

10910 LTARYGNIFSVQFGGLTFVVVSGYQMVREALVHQAEIFADRPHIPLLQEIFRGF  10749

10125 GLISSNGHIWRQQRKFVSATLKSIAVSFESKVQEESRYLVEAMEEEK  9985

8514  GQPFDPHYKINSAVSNIICSITFGNRFNYHDSNFQELLHLLAETLLLIGSFWGQ  8299

7615  LYNAFPLIMRWLPGPFRKIFRHWEKLQRFVRGVIAKHKEDLDQSDLGDYIDCYLKEIEK  7439

7077  CKGDTNSYFHEENLLCSTLDLFLTGTETTATAIRWALLYMAAYPHIQ  6937

6401  EKVQLEIDAVIGQCRQPTMEDKEHMPYTSAVLSEVLRMGNIVPLGVPRMSTNDTTLAGFHVPK  6213

5285  GTTLMTSLTSIMFDKNVWETPDTFNPEHFLENGQYRRREAFLPFSA  5148

4669  GKRACPGEQLARTELFIFFTALLQKFTFQAPSATVLSFAFTLSLTRCPKPFQLCALPR  4496

 

>CYP2J-like BU143341 found by Kun Cheng, A. Nico West

CD728904 BU118162 BG710067 CC311047 (GENOMIC)

57% to 2J2 42% to 2H2

MLRFLWDSISLQMLFVFLLVFLLVSDYMKKRK

PKDFPPGPFSFPFLGNMEFIIAKDPVAVTEKFIEKHGDIFSTQVGSMSFVIVNGLPLIKE

ALVTQGENFMDRPEFPINTEFLNKF

GLVFSNGHLWKQQRRFTLTTLRNFGLGKRSLEERIQEECRFLTDAFRDEQGNPFNPHLKVNNAVSNIICSVT

FGNRFEYHDEDFQNLLRLMDETVTLQGEPMSQL YAFFPSIIKYFPGSHQTVLKNEKLMKRFVCKKIS

KHKEDLSPSESRDFIDSYLQEMAKPNGSDFCEDN

MVSCTLDLFFAGTETTSTTIRWALLYMAIYPEIQARVQAEIDAVIGQARQPSLEDRSN

MPYTNAVIHEVQRKGNIIPFNVPRQAVKDTVLAGFRVPKGTILIPNLSSVMYDKKEWETP

HSFNPGHFLKDGQFWKREAFMPFSIGKRACLGELLARAELFLFFTALLQKFTFQAPPDTI

LDLKFTHGMTLAPQPYKICAVPR*

 

>CD218206 cDNA clone pgr1n.pk006.b19 5' AJ454171 86% to 2J-like

    MLRFLWDSI

2   SLQMLFVFLLVFLLVSDYMKRRKPKDFPPSPFSFPFLGNVQFMFAKDPVVATQKLTEKLG 181

182 DIFSMQAGTQSFVIVNGLPLIKEALVTQGENFMDRPEIPLDTDIFSKLGLISSSGHLWKQ 361

362 QRRFTLTTLRNFGLGKRSLEERIQEECRFLTEAFRDEQGNPFNPHLKINNAVSNIICSVT 541

542 FGNRFEYHDENFQNLLRLMDETVTLQGEPMSQL 640

 

>CC229946 Gallus gallus genomic clone BU457300 BU364406

          Length = 1029

57% to 2J2 52% to 2N10 might be the bottom of CD218206

EDIQALGETAAFVRGVMQNTRRTGP

DQSDLGDYSDCYLKEIEKCKGDTNSYFHEENLLCSTLDLFLTGTETTATAIRWALLYMAAYPHIQ

EKVQLEIDAVIGQ

CRQPTMEDKEHMPYTSAVLSEVLRMGNIVPLGVPRM

STNDTTLAGFHVPKGTTLMTSLTSIMF DKNVWETPDTFNPEHFLENGQYRRREAFLPFSA

GKRACPGEQVARTELFIFFTALLQKFAFQAPSXXXXXXXXXXXXXXX

PKPFQLCALTRC*

 

>BU357519 cDNA clone ChEST362n3 5' Length = 821 54% to 2J2 BU313454 BU302565

CD727856  BU131508 BU491829 BU490535

51% to 2D6, 45% to 2J-like chicken

    MTLLLWLSSWSNISVLGVFLTVFTILVDFMKRRKKWSRYPPGPMPLPFVGTMPYVNYYNPHL

    SFEKFRKKFGNIFSLQNCWTNVVVLNGYKTVK

    EALVNKSEDFADRPYMPVYEHLGYGHKSEGLCLARY

2   GHLWKELRKFTLTTLRNFGMGKKSLEERVTEEAGFLCSAISSEGGHPFDPRFLVNNAVCN 181

182 VICTITYGERFDYGDKTFKKLLTLFENSLNEEAGFLPQLLNVAPVLLRIPGLPQKIFPC 358

359 QKAYVDFTQMLIDKHKETWNPAYIRDFTDAFLKEMAKGKEAEENGFNKSNLTLVTADLLV 538

539 AGSETTATTLRWAFLFMLLYPEIQSKVHKEIDKVIGRNRPPTMADQVNMPYTNAVIHEVQRFGDVVPM 741

    GLPHMTYRDTELQGFFIPK

 

>BX269834 cDNA CC255621 genomic clone 54% to Gga.7041

18aa in a row with 2W1 (50%) BU233174 BG711234 AJ445737

MAFLISFISDPVLMGLLCAAVLLAVLYF

STGSKNAAFKLPPGPTPLPIIGNLHLVDIRRQDKSLMK

LAEEYGPVFTLHFGFQKVVVLTGYEVVREALVN

YTEEFVDRPSIPIFDQIQNGNGVFFSIGDLWRTTRRFTVSSM

RNLGMGKQMMEGKVCEELHFLIEKIKSFKGEPFSLRSFSIAPINITFLMLFGDRFDYKDP

TFLTLLRLIDEVMVLL

GSPYLNYFNFYPFLGFLFKTHKILLKKIEDVRVIIRQYMKASREDISENSVRSYTDA

LVFKQHEEKNKKDSLFHDDNLIASILDLVMAGTETTATTLQWAILLMMKYPEIQKKVQEE

IGRTVKAGSWVTYEDRKNMPFTNAVIHEVQRFITLLPHVPRCTAVDTHFRGYFLPKGIIV

IP

 

>CYP2U1 related BU329140 found by Payal.Khandelwal

EGSVIVPNLISRWTEILIFEENPDDFQPTRFLDENGQIIKKEAFIPFGMGKRVCMGEQLAK

MELFLIFTSLMQSFTFLYPENATKPSMEGRFGLTLAPCPFKIIALER*

 

>Gga.7041 Links 58% TO 2K11 FUGU 57% to 2AC1P human 56% to 2AC1 mouse

LENVKEVNDFIKVTFTKYLQVLDKNDQRSFIDAFLVKQQEQNEKANKFFDDENLTEVVRN

LFTAGMDTTATTLRWGLLLMMKYPEIQKKVQ

REEIDRVIGSNPPRTEHRTKMPYTDAVIHEIQRFANILPLNLPHETTMDVTIKGYFIPKG 186

TYIIPLLNSVLQDKTQWEKPCSFHPEHFLNSEGKFVKKDA

FIPFSAGRRICAGETLAKMELFLFFTSLLQRFTFQPPPGISSSDLDLSAPPRFVIAP

VTHEVCAVSRS*

 

>CYP2AC1 chicken NW_060338.1|Gga3_WGA147_1 chr 3 XM_420052.1

BG641890.1 EST

3967773 MDWASVVPVGLLMILILLLILKTQDFWRSQGKFPPGPQPLPIIGNLHIMDLKKIGQTMLQ (0) 3967952

3968877 LSETYGPVFTVQMGMRKVVVLSGYDTVKEALVNHADAFVGRPKIPIVEKAGKGK  3969038

3969203 GVVFSSGENWKVMRRFTLTTLRDFGMGKKAIEDYVVEEYGYLADVIESQK  3969352

3970285 GKPLEMTHLMNSAVANVIVSILLGKRFEYEDPTFKRLVSLINENMRLFGSPSVS  3970446

3971108 LYNMFPILGPFLKDNKSFLENVKEVNDFIKVTFTKYLQVLDK  3971233

3971234 NDQRSFIDAFLVKQQE  3971281

3971703 QNEKANKFFDDENLTEVVRNLFTAGMDTTATTLRWGLLLMMKYPEIQ  3971843

3971973 KKVQEEIDRVIGSNPPRTE  3972029

        HRTKMPY

3972269        TDAVIHEIQRFANILPLNLPHETTMDVTIKGYFIPK  3972376

3972609 GTYIIPLLNSVLQDKTQWEKPCSFHPEHFLNSEGKFVKKDAFIPFSA  3972749

3973027 GRRICAGETLAKMELFLFFTSLLQRFTFQPPPGISSSDLDLSAPPRFVIAPVTHEVCAVSRS  3973212

 

>CYP2AC2 chicken NW_060338.1|Gga3_WGA147_1, chr 3 BG710846.1 EST, XM_420053.1

3974997 MALVFILTFLFIMKIGGLWSNHWRKNFPPGPRALPIIGNLHLFDLKRPYRTYLQ  3975158

3976589 LSKEYGPVFSVQMGQRKIVVISGYETVKEALINQADAFAERPKIPIFEDLTRGN  3976750

3977081 GIVFAHGENWKVMRRFTLTTLRDFGMGKRAIEDRIVEEYGYLIDNVGSQE  3977230

3977626 GKPFDASKIINAAVANIIVSILLGKRFDYKDSRFIRLQHLTNESMRLAGKPLVT  3977787

3978987 MYNIFPYLGFLLRANKTLLKNRDEFHAYVKATFLENLKTLDKNDQRSFIDAFLVKQQE  3979160

3979765 EKSITNGYFHNGNLLSLVSNLFTAGVETISTTLNWSFLLMLKYPEIQSKVQ  3979917

3980773 EEIEQVIGSNPPRIEHRTQMPYTDAVIHEVQRFANILPLDLPHETAEDVTLKDYFIPK  3980946

3981123 GTYIIPLLTSVLRDKSQWEKPDMFYPEHFLDSKGKFVKKDAFMPFSA  3981263

3982308 GRRICAGETLAKMELFLFFTSLLQRFTFQPPPGVSSSDLDLSPAISFNVVPKPYKICAVARS  3982493

 

>CC322700 genomic clone TAM32-2H22. 38% to 2W1 CYP2 PSEUDOGENE?

237 DIVLSGTETTSTTLEWVGARLLQHPEAMNRVQEELDEGVRLDNCIELESQLSKL*CLEP 413

414 VLKETLWLAPPLPFQIPRGPDPTNTVGGYTIPK 512

 

>CC194181 Gallus gallus genomic clone CH261-182H7. BI390850

          Length = 1047 48% to 2P4 41% to 2J2

MDFRFWPISQLGKLNVSMLLVVLV

MFLLIIDFVRKRRPRNFPPGPQLFPLVGTIVDLRQPLHLEMQKLTARYGNIFSVQFGGLT

FVVVSGYQMVREALVHQAEIFADRPHIPLKQEIFRGFG

 

>2R1 BM489821 FOUND BY Salar Khan Nawazi CB017803 BU107789 BU395606

HVYMRRQSQIHGQ IFSLDLGGISAIVLNGYDAVKECLVHQSEIFADRPSLPLFKKLTNMGGLLNSKYGRGWT

EHRKLAVNTFRTFGYGQRSFEHKISEESVFF LDAIDTYKGRPFDLKHLITNAVSNITNLI

IFGERFTYEDTEFQHMIEIFSENIELAASASVFLYNAFPWIGILPF

GKHQQLFKNAAEVY DFLHKLIER

VSENRKSQSPRHFIDAYLDEMDCNKNDPESTYSRENLIFSVGELIIAGTETTTNVLRWAV

LFMALYPNIQGHVQKEIDLVIGPNKMPALEEKCKMPYTEAVLHEVLRFCNIVPLGIFHAT

SKDTVVRGYSIPEGTTVITNLYSVHFDEKYWNNPEVSFPERF

LDSNGQFVKKDALXX

FSLGRRHCLG

EQLARMDWFXXXXXXXX

RFHLRF

 

>BG712952  BG710205  46% TO 2Y2 45% TO 2F1 44% TO 2C8 46% TO 2H1

found by Wenhua Jiang

LIRELEKGGDAVQDPTELLSAAVGNVGLRLLCGRRFPYEDMGYRDALRRNAENLRIESSA

AGKLYNALPALLDLLPGPHQRFFRNSAIVRRFLDGISVGGSEKGGQTSRDFISAFRRKME

EEKDVPGSPFTAANLRVTTYDLFLAGTETTSMALRYGLMALLGNPHIMERLQEELDVVVGSDRLPSLRDRLALPYTDA

VIHEVQRHLDLIPLGFVRTVTRDTPFRGYVIPKGSTIYPVLSSALKDPHYFPDPERFDPQ

HFLDSEGKFRRCEAFIPFSAGRRMCIGEPLARTQLFIFTTALLQR

 

>CYP3A37     Gallus gallus (chicken) found by Kelly Earhart

MNFLPFFSIETWIILLIFVVLLIIYGTWPFGLFKKLGIPGPRPL

PFFGTCLEYRKGFLDFDTECFQKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF

TNRRRTDLAGVLRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKYFGEMLVKNI

QKRVEKNSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP

VFILSFVCPFLTPLMAKMNISFFPSDAVDFFMRSIDKIKKDRERETHTGRVDFLQMMI

ESQKSDSNGSSDAKHSYKALSDIEVLSQAFIFIFAGYEPTSNTLGYLAYQLALHPDVQ

QKVVNEIDTILPNKAPLTYEAIMQLEY LDMAVNETLRLYPLGGRLERTCKRDVEINGV

TIPKGTIVIIPPYTLHRSPEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIG

MRFALLTLKVAITAVLQHFTFQVCKETQIPLKLQSLGLTTPEKPIVLKLVPR TNTAKA

 

>60% to 3A4 61% to 3A37 new seq in CYP3A

found by Fei Cao, Lai Wei, Michael Mohler, Ioana Moisini, Wei Liu, Yang Zong

BU250947 BU246013 CD735929 BU472711

MGLLPDLPPITWLLLAAFLGLLVLYGIWPYQTFKKLGIPGPRPLPF

LGTFLRYRQGLLNFDQMCFEKYGKIWGIYDGRQPVMAILDPVLIKTILVK

ECYSTFTNRRVFGLSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKL

VKNIEKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPSDPFVTNIRKFLKFSFLNPLLIFIVLFPF

MIPVLEKMNVTLLPTKVMDFFDAVFMKMKKEREEGYHVDRVDFLQLMIDSQSSQDSSKSAR EKDSY

KSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDVQKRLQDEIDANLPNKAAPTY
NVVMQMEYLDMVVNESLRLHPPGGRIERICKKTVEFNGVTIPKDMVVMIPAYVLHRDP
AYWPKPEEFRPERFSKENGENIDPYTFLPFGAGPRNCIGMRFALLIVKVAMVVLLQNFSF
KPCKDTPIPLVLDTKGFMQPKKPIILKMVPR AHSDPEN*

 

>Gga.7197 59% to 4B1 and 57% to 4A11 52% to 4X1 50% to 4Z1

found by Ajit Narang, M. Nooh, Leslie Hunt, Stephanie Nance

MKATWFGVDVARVLHL

AAVFCLTCVLLKAIQLYHRRRELLRALSAFPGHPTHWLLGHVQEFLKEEDVLEKAEAWAL

KYQHAHPIWFGGFSAVLVINDPEYAKALFARGDPKDNLSYKHLIPWIGNGLLILHGPKWH

QHRKLLTPGFHYDVLKPYVALMAESTNVMLDKWEKLITN

GKSVELFEHVSLMTLDSIMKCAFSYHSNCQTDRQNTYIQAVYDLCRMVHERLRIFPYHND

FIYWLSPHGYQFRKVCQLAHDHTDKVIQERKESLKDEREFEKIKKKRHLDFLDILLCA

KDETGAGLSDEDLRA

EVDTFMFEGHDTTASGLSWVLYCLASHPEHQARCREEIKDILGSRDTIQWEDLGKMTYST

MCIKESLRLYPPVPGVSRQLSKPITFHDGRTLPEGTITAISIYLIHRNPLVWKDPL

VFDPLRFSPENVSGRHSHAFLPFAAGMRNCIGQ

QFAMIEMKVALALILLRFELSPDLTNPPHKIPRLILRSKNGIHLYLKKIH*

 

>related to 4B1/4A11 seqs 56% to 4A11 56% to 4B1 49% to 4X1 49% to 4Z1

found by G. Van Alstine

MVSLLDNIARPS

AVILQLSVVLGVIFVLLKVVRFYQGRKKILKALEAFPGPPAHWLYGHNHLITGDKVLNL

LVSLGEEYPYAFPRWFGPVLPSLIVHHPEYAKTILGRGDPKPPVPYQFLVPWIGKGLLVL

SGTKWFQHRKLLTPAFHYDVLKSYVSLMSDSVKVMLDKWEKKKSVELFEDVSLMALDSIMKCAFSYNANCQ

TQSNSDTYIKAVFDLGYLINKRIQNFSYQDAF

YDLTHSSREFQDACRRAHAHTDKVIQERKILLSNDKELDKIRKKRHLDFLDILLCTKDEN

GVGLSDEDLRAEVDTFMFEGHDTTASGISWLLYCMALHPKHQALCREEIQG

IMGNRDTIEWEDLGKMTYST

MCIKESLRLFPPVPAVSRRLSKPVTFSDGRSLPEGSQVSLNIFGIHRNRDVWEDPEVFDP

LRFSPENSAHRHSHAFLPFSAGSRNCIGQQFAMNEMKVALALTLLRFELFPNASKPPMLT

QQLILKSRSGIHLHLKKIC*

 

>New CYP4F family member 63% to 4F22 CD735260 BU124422 CD731342 CD737432
found by Jie Shen, Lei Yang
MVLSWLLVALLVALLVAWLRDAVVTVTRFRATCQQLRHFPLPPWRNWLLGHTGMARNTEE
GLQDVDKVVAQYRHGCLWWLSPWLPILRLFHPDTLRPVLMASAFTAPKDKLFYGFLKPWL
GDGLLLSRGDKWARHRRLLTPAFHFDIL
KSYVSIFNSSTHIMHTKWRAAAKAVGGPVGRNMMEDLSLLTLDTLQKCIFSHDSHCQEQR
SEYIEAILELSTLVVRRQQRLLHHTSWLYRLSADGRRFARACATVHSFTANVVQRRRQEL
NHLGHQAWLKGRQGRSTDFIDLLLLTKDE
DGNTLSDEDISAEADTFMFEGHDTTASGLAWLLYNLAHHPHYQEQCRQEVRELLKGRNVE
EIEWEDLSLLPFTTMCIKESLRLHPPVTAVSRRCTEDIAMRDGRVIPKEVICLMSIYGTH
HNPDIWPEPQVYDPLRFSPENSQGRSPLAFIPFSAGPRNCIGQSFAMAEMKVVAALTLARFAV
RPDPARPVRRKSELILRAEDGLWLQLEPLSAMP*

 

>CYP4V BU122915 BU456889 BU382948 BG710225 BU250926 58% TO 4V5

found by Y. Zhuang

MAMEITLGSMEGTQLLPW

VAGAITLLLTVVTVHFLPSLLNYWWWWWVMKPIPGIRPCYPFVGNALLLERNGEGFFKQL

QQYADEFRKMPMFKLWLGPLPVTVLFHPDSVEVILSSSKHIKKSFLYTFLHPWLGTGLLT

STGDKWRSRRKMITPTFHFAILNDFLEVMTEQGGVRSEKLEKHVDKEPFNIFTDITLCAL

DIICETAMGKNLGAQDNKDSEYVRAVYRMSDLIQQRQKSPWLWHDLMYLLFKEGREHERNLKIL

HGFTDTVIAEQVAELENTKLTKHDTDVNTEEESGSK

KREAFLDMLLNATDDEGKKLSYKD

IREEVDTFMFEGHDTTAAAMNWVLYLLGHHPEAQKKVHQELDEV

FGNAERPVTVDDLKKLRYLECVVKEALRLFPSVPMFARSLQEDCYISGYKL

PKGTNVLVLTYVLHRDPEIFPEPDEFRPERFFPENSKGRHPYAYVPFSAGPRNCIGQRFA

QMEEKTLLA LILRRFWVDCSQKPEELGLSGELILRPNNGIWVQLKRR

 

>CYP5A1    chicken

           XP_416334, 63% to human CYP5A1

  1 MAAQPSAAAL TLTLSSAAEG WPMLQRGDAG RWQEDGGLVS FQGGNYIPCD KYSTSAFSKL

 61 SKVGIRHPPP LPFIGNLLFF REGFWENHTK LITEYGPVCG YYIGRQMFVV ISTPEVIKQI

121 LVTDFGNFTN RTKPNLISKP MLDSILCLRD ERWKYVRSLL TPAFSDAKLK EMIPLINQAC

181 DVLLSNLKVY ADSGRAFDIQ RCYNCFTLDV VGSVAFGTEV DSQKNPDDPF VKNCRTFFEM

241 SLFKPLLFLI LSFPFIMIPL LRILPNKKQK ELNGFFIQTI KNAIAFRDQQ DAAERRRDFL

301 QWMLDSRNSA DALAGGYFDQ ICPATTSSHN EVPLVDKTPS EKAQKMLTED EIAGQAFLFL

361 IAGYETTTST LSFATYLLAT NPECQEKLLQ EIDEFSAKHM AQDLCALEEN LPYLDMVIAE

421 TLRMFPPAFR FTREAAKDCV VLGQRIPAGA VIETAVGHLH HNPEFWPEPE KFIPERFTEE

481 AKKERHPFAY LPFGAGPRGC IGRKMGLLAT KMTLLRILQM FRFKTCPETE IPLQLKSKAT

541 LGPKNGVYII LESR

 

>CYP7A1      Gallus gallus (chicken) FOUND BY K. CHENG

MFIAPWIWGTVIIVCCSFWFLFGRRRRRRQGEPPLENGFLPYLG

CALQFGANPLKFLREKQKKHGHIFTCQVAGKYIHFLTDPFSYHSLIRQGKHLDWKKFH

FATSAKAFGHGSIDPAEGNTTENFHHTFIRTLQGNALDALIKAMMENLQYVMLQSRAS

KFQPNTWVTEGLYTFCCQVMFESGFLTLFGKEFNSNHDKNLSKRETERARILNALENF

KEFDKIFPALVAGLPIHLFKSAHSAREKLGEALLHKNLLKRDNLSELVMLRMFLNDTL

STFDDMEKAKTHVAVLWASQANTIPATFWSLFYLL KNPEAMRAATKEVQSVLESAGEK

ISLDGNYISLNRKQLDNMPVLDSIIKEAMRLSSASMTFRVAKEDFTLHLENSFYNIRK

DDIVALYPQLLHFDPEIYADPLTLKYDRYLNENKEEKTDFYRNGRKLKYYYMPFGAGI

AKCPGRLFAVHEIKQFLVLIFSYFEIDLVDSNVQCPSLDQSRAGLGILQPSNDIDFRY

RLKCL

 

>CYP7B 58% to human 7B1 found by G. Van Alstine BU288555

AY700579 mRNA partial

PWRRSAGGAAAAALLLWVVCVLCRRKRKTGEPPLINGWIPYLGK

ALPFRKDAFKFLLDQQKKLGDIFTVHIAGRYITFIMDPFQYVYVIRNSKQLEFHEFAD

KMASKTFDYPALSNVKFPDLKENLHRIYQYLQGKPLEIISDHMMKNLQDIFEWKCSQA

TDWETEKMYKFCCSVMFEASFVTLYGRVPAADGRKVISEIRDKFIKFDASFPYLAANI

PIELLGATKKVRKELIHHFLLQNMTKWLGGSKVVQARQDIFEKYELLGDYDKAAHHFA

FLWASVGNTIPATFWAMYYLLRHPEALAAVRDEITHLLQSTGQKRGPTYNIHLTREQL

DNLVYLESALNESLRMCSSSMNIRISQEDFVLKLEGDQEVSLRKGDWIALYPQILHMD

PEVYEDPKKYKFDRYIENGKKKTTFYKAGRKLKYFLMPFGSGISMCPGRFLAMNEMKM

FLFLLLAHFDVELGENKAVRLDNSRM

 

>CYP8B 58% to 8B1 Fugu 53% to 8B1 human BU126059 BU434350 BU433331 BU242835 
found by Yi Jin, Salar Khan Nawazi, Payal.Khandelwal

MTFWAVFLCTLAVSLLGGLYVLGTFRRRRPNEPPLDKGIIPWLGYALDFRQDSSGFLS

KMQRKHGDIFTVLIGGHYFTFVMDP

LLLGAIVKESRSKLDFLTFAAKXVLRVLGYKSNKD

NNSALHSFNTKHLMGEGLSLLTQATMDNF
QKLMLFKLSSGEEKQPWQEAGLFHYCYNIVFRAGYLALYGTESYQGTGNKEKAHEQDLIH
SNQLFTEFRKYDRLFPRLAYAVLPPKDKVEAERLKRFFWDALSVSKDSQKENVSRWISEQ
DQYLAESGVPDYMRDRFKFMMLWAS
QGNTGPTAFWLLLYLMKDPEAMKAVKGEVEKVLREHGQEVKPGSPPVNITRDMLDQTPFL
DSAVEETLRLVAAPILIRAVLQDVNLKMSSGREYTLRKGDRVALFPHLSVQMNPEIHPEP
HKFKYDRFVNPDGTKKDFYKNGKRLKYFNMPWGAGVSTCPGRFFATAEMKLFVFLMLT

HYDLELVNDKEEIPAIDSSRWGFGTMQPVHDVRFRYRPRV*

 

>CYP11A1 PIR JC6200 cytochrome P450scc" 53% to 11A1 human 62% to 11A1 Fugu

found by Lai Wei, Ioana Moisini

  1 MLSRAAPIAG SFQACRCAGG IPALAGVHYP LPSSSGARPF DQVPGEWRAG WLNLYHFWKE

 61 GGFHNVHNIM ASKFQRFGPI YREKLGVYES VNIISPRDAA TLFKSEGMLP ERFSVPPWVA

121 YRDYRNKPYG VLLKTGEAWR SDRLTLNKEV LSPQVVDSFV PLLDQVSQDF LRRARAQVQQ

181 SGRERWTADF SHELFRFALE SVCHVLYGER LGLLQDFVDP EAQQFIDAVT LMFHTTSPML

241 YVPPALLRHL NTKTWRDHVH AWDAIFTQAD KCIQNVYRDI RLQRKSTEEH TGILFSLLVQ

301 DKLPLDDIKA SVTEMMAGGV DTTSMTLQWA MLELARSPGI QERLRAEVLA AKQEAQGDRV

361 KMLKSIRLLK AAIKETLRLH PVAVTLQRYT TQEVILQDYR IPPKTLVQVG LYAMGRDPEV

421 FPKPEQFNPE RWLVMGSKHF KGLSFGFGPR QCLGRRIAEL EMQLFLMHIL ENFKIETKRA

481 VEVGTKFDLI LVPEKPIYLR LRPLQPQE

 

>CYP17A1 PIR P12394 BX274392 found by Kelly Earhart, Teresa Liu

  1 MPPLAVLLLA LALLCAWRLS YSQGPTGTGT GRPRSLPALP LVGSLLQLAG HPQLHLRLWR

 61 LQGRYGSLYG LWMGSHYVVV VNSYQHAREV LLKKGKAFAG RPRTVTTDLL SRGGKDIAFA

121 SYGPLWKFQR KLVHAALSMF GEGSVALEKI ICREAASLCE TLGAAQDMAL DMAPELTRAV

181 TNVVCSLCFN SSYRRGDPEF EAMLEYSQGI VDTVAKESLV DIFPWLQIFP NRDLALLKRC

241 LKVRDQLLQQ KFTEHKEAFC GDTVRDLMDA LLQVRLNAEN NSPLEPGLEL TDDHLLMTVG

301 DIFGAGVETT TTVLKWAVLY LLHYPEVQKK IQEEMDQKIG LARHPHLSDR PLLPYLEATI

361 SEGLRIRPVS PLLIPHVSLA DTSIGEYSIP KGARVVINLW SVHHDEKEWD KPEEFNPGRF

421 LDEQGQHIHS PSPSYLPFGA GIRVCLGEVL AKMELFLFLA WVLQRFTLEC PQDQPLPSLE

481 GKFGVVLQVQ KFRVKARLRE AWRGEMVR

 

>CYP19       chicken (three different strains of chicken) found by C. Lancaster

  1 MIPETLNPLN YFTSLVPDLM PVATVPIIIL ICFLFLIWNH EETSSIPGPG YCMGIGPLIS

 61 HGRFLWMGLG NACNYYNKTY GEFVRVWISG EETFIISKSS SVFHVMKHWN YVSRFGSKLG

121 LQCIGMYENG IIFNNNPAHW KEIRPFFTKA LSGPGLVRMI AICVESTIVH LDKLEEVTTE

181 VGNVNVLNLM RRIMLDTSNK LFLGVPLDES AIVLKIQNYF DAWQALLLKP DIFFKISWLC

241 KKYEEAAKDL KGAMEILIEQ KRQKLSTVEK LDEHMDFASQ LIFAQNRGDL TAENVNQCVL

301 EMMIAAPDTL SVTLFIMLIL IADDPTVEEK MMREIETVMG DREVQSDDMP NLKIVENFIY

361 ESMRYQPVVD LIMRKALQDD VIDGYPVKKG TNIILNIGRM HKLEFFPKPN EFSLENFEKN

421 VPSRYFQPFG FGPRGCVMMK AILVTLLRRC RVQTMKGRGL NNIQKNNDLS MHPIERQPLL

481 EMVFTPRSPN KNQSD

 

>CYP20 Gga.3304    Gallus gallus (chicken)

MLDFAIFAVTFLLILVGAVLYLYP

ASRQASGIPGLAPTDDK

DGNLPDIIASRSLHEFLVNLHEKYGPLVSFWFGRRLVVSLGSIDLLKQHVNPNRSS

DPFEMMLKSFLRYQSSLNGDTGESHLRRKLYESGVSKSLQSNLALIQK

LSEELLAKWLSLPEAQHIPLCQHMLGFAMKSVTQTAMGSSFEDDQEVIRFRRHHDA

IWSEIGKGFLDGSLDKNATRKKLYED

ALKEMESTLRKVITGTPRQIIQQAFIDTLLQGNLSDQQ

ILEDTMIFSLAGCIITAN

LCTWAVYFLTTSEDVQQNLCKEVDHVLGKGPITHEKIEQLR

YCRQVLCETVRTAKLTPIAAQLQELEGRVDQHTVPKE

TLVLYALGVMLQDSSSWPSPYK

FDPERFSEDSAMTNFSLLGFSGSQECPELR

FAYMVATVLLSILVRKLYLHPVKGQVMETKYELVTSPKEEAWITVSKRS*

 

>CYP24 69% to human AF019142 mRNA AF428109 (partial)

found by Teresa Liu

MGGCSILLRSSALTCGRPRSSPPGAEVRCRGRRPLCALRGRGHP

LAALPGPPSWPLMGSLPDVLWKGGLKRQHETLAEYHRRFGKIFRMKLGAFDSVHIGAP

CLLESLYRRESSCPQRLEIKPWKAYRDYRDEGYGLLIL EGKDWQRVRSAFQKKLMKPK

EVVKLDNTINEVLEDFMHRIDEICNHNGQMEDVYSEFNKWSFESICLVLYGKRFGLLQ

QDVEEESLNFIKAVKTMMATFGMMMVTPVELHKGLNTKVWQAHTKAWDDIFKTAKHSI

DSRLQRHSANPQEDFLCDIYSGGQLSKKELYATIAELQIAGVETTANSLLWALYNISR

NPHVQQKLLQEIQSVLAANESPTAESIKNMPYLKACLKESMRLTPSVPFTTRTIDTEM

VLGDYVLPEGTVLMINSYALGCNEEYFNGWTQFKPERWLQKHSINPFSHVPFGIGKR

MCIGRRLAELQLHLALCWIIRKYQLVATDDNPVETLHSGILIPSRELPIAFHRRLQLD

 

>CYP26A PIR Q9PUB4 79% to 26A1 human AF185266 BU321681

found by Jun Shen, Marie van der Merwe

  1 MGFSALVASA LCTFLLPLLL FLAAVRLWDL YCASGRDPSC PLPLPPGTMG LPFFGETLQM

 61 VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGAENVRHI LLGEHRLVSV QWPASVRTIL

121 GSGCLSNLHN GQHKHRKKVI MQAFSRDALQ HYVPVIQEEV SACLAQWLGA GPCLLVYPEV

181 KRLMFRIAMR ILLGFQPRQA SPDGEQQLVE AFEEMIRNLF SLPIDVPFSG LYRGLRARNI

241 IHAKIEENIR AKMARKEPEG GYKDALQLLM EHTQGNGEQL NMQELKESAT ELLFGGHETT

301 ASAATSLIAF LGLHHDVLQK VRKELQLKGL LSGPNQEKQL NMEFLEQLKY TGCVIKETLR

361 LSPPVPGGFR IALKTLELNG YQIPKGWNVI YSICDTHDVA DLFTDKDEFN PDRFMSPSPE

421 DSSRFSFIPF GGGLRSCVGK EFAKVLLKIF TVELARSCDW QLLNGPPTMK TGPIVYPVDN

481 LPAKFIGFSG QI

 

>CYP26B1  chicken

          XM_426366

          missing N-term, 86% to CYP26B1 human

EVFSKI

FSHEALESYLPKIQLVIKDTLRAWSSNPDPINVYHEAQKLTFRMAIRVLLGFHIPDEE

LSRLFEVYQQFVENVFSLPVDLPFSGYRRGIRARETLQRGLEKAIQEKLQNTQGKDYA

DALDILIESGKEHGKELTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPRVLEKL

REELRSKGILHNGCICEGSLRLDNISGLHYLDCVIKEVLRLFTPISGGYRTVLQTFEL

DGFQIPKGWSVMYSIRDTHDTAPVFKDVDVFDPDRFGQGRSEDKEGRFHYLPFGGGVR

TCLGKHLAKLFLKALAIELASSSRFELATRTFPKITLVPVVHPVDGLKVKFFGLDSNQ

NEILTGTDVMLGATV

 

>CYP26C1  chicken

          XP_421678, XM_421678.2

          70% to CYP26C1

  1 MRSGRDAVRR RGAAGSRLGS GWVGPGWAVG GEPRGASPQG AVAATPVRPA PLPSIPALRL

 61 QSPHLAALLK YAGETSSAKV DRALSGQYLY KCGRGEKREQ EPCGGISHWL LQGSRFHSSR

121 RERYGNVFKT HLLGRPVVRV TGAENVRKIL LGEHTLVSAQ WPQSTQILLG SHTLLGSTGD

181 LHRQRRKILA RVFCRAALES YLPRIQKVVS WELRGWCMQP GSIAVYSSAK TLTFRIAARI

241 LLGLRLEEKQ FKDLAKTFEQ LVENLFSLPL NVPFSGLRKG IKARDMLHEF MERAIQEKLQ

301 RAISEEHSDA LDFIINSAKE HGKEFTMQEL KESAIELIFA AFFTTASAST SLILLLLKHP

361 SAIEKIRQEL VSHELPQPRG CRCPLDISLE QLSRLRYLDC VVKEVLRVLP PVSGGYRTAL

421 QTFELDGYQI PKGWSVMYSI RDTHETAAIY QSPPGGFDPD RFNVTHLEAA GRFHYIPFGG

481 GARSCIGKEL AQAILKLLAI ELVTTARWEL ATPTFPAMQT VPIVHPVDGL QLYFHPLRPS

541 HGGEA

 

>CYP27A BG712223 BG710276 BG641499 found by A. Nico West

DAWVDPRVRAGPSGGARRLLLPLRLRPPPPIGPEPPCRTGS

SAAAAAAGPARLKGPAELPGPGLLRTFVWLFLRGYLLHTHRLQLMSRRIYGPIWKST 268

FGHYQNINIGSPVVLEQLLRQEGKYPMRSDMALWKEHRDTRRLPYGPFTEEGERWYRLRQ 448

VLNKRLLKPSEAVLYA DAIGEVVSDLMVRLRDERSRSPSGVLVGDVANLLYRFALEGISYILFETRIGCLKQQVPP 183

ETQHFIDSINLMFKNSIFATVLPRWSRKVLPFWDRYLDSWDTIFAFGKRLIDRKMKELEG 363

HVXKGKEVSXXYLSYLLASGHLSLDEVYGSVAELLLAGVDTTSNTLCWALYHLSRD 531

LGIQDTLY XXLKAVV 576

34 aa gap

LAHYAMSHDETYFPEPERFLPQRWLRGHGSPHHPFSSIPFGYGVRACVGRRIAELEMHL 180

ALARIIXAYEVR 216

 

>CYP27C1    Gallus gallus (chicken) Partial seq missing N and C-terminals

found by Yang Zong

PGLSGSQSLEVRSGAENKAARPGELLEPSPQLGRV KSLHEMPGPNTLYNLYEFFWKDGFGRIHE

IQ QKHTQEYGKIFKSHFGPQFVVSIADRDMVAQVLRSEGRAPQRANMESWQEYRDLRGR

ATGLISAEGEQWLKMRSVLRQKILKPKDVAVYSGGVNEVITDLIKRIYTLRSQEEDGETV

TNVNNLFFKYSMEGVATILYECRLGCLENNVPQQTVEYIEALELMFSMFKTTMYAGAIPR

WLRPFIPKPWREFCRSWDGLFKF SQIHVDNKLKSIQS

QLDQGEEVNGGLLTYLLVSKELTLEEIYA

NMTEMLLAGVDTTSFTLSWAIYMLAKHPEVQQRVYEEIINKLGKDQAPVNRDVPKLPLIR

AVLKETLR

 

>CYP39 like  found by Marie van der Merwe, Wenhua Jiang

57% TO 39A1 HUMAN

BG712800 BG710422 BU226060 AI979980 BU247492 BU226060

AAAVLLAALLAVAVVAWVLFPPSEP

RRPPCIGSRVPCLGAAF

RLARAPLEFIERARAEHGPIFTVFALGKRFTFVTEDEGAEVFFTSKDLNFEQAVQRVV

ANAVSVPAEAFYQNHGRLYSMMKGKMGPSNLHMFTGTLCKELHEHMAHLGTAGTGDLMEL

VRHIMYTAVVNTLFGKGACPTSHSELREFEEHFWKYDEDFEYASQMPECFLRNWSKSKKW

LLKLFEKVVSDAERTNPSETTSKTLLQHLLDNLQGKTS

HLAPNYGLLMLWASQANAVPIAFWTLVFILSSP

SVYKKVMEDLTSVFGNAGKDEIEVSEEDLKNLPYIKWCTLEAIRLRSPGAITKKVIKPIR

IQSFTIPAGDMLMLSPYWLHRNPKYFPDPEMFKPDRWKEANLEKNAFLDGFVAFGGG

NHQCPGRWFAIMEIQLLVALFLYKYEFVLLDAVPKESPLHLVGTQQPLTPFRVQYKGWE*

 

>CYP46 like seq found by Jun Shen BG711830 BU455713 BU301503

BU300015

XXXLLLLLALLLLLVAGLYCCYVRRVHAAYDHIPGAPRESFLLGHLPIFWRMMKKQEFLH

DLFLEWTKKYGPIIRVNAFHRVSVLILSPEGVKEFLMSPEYPKDRLVYGRIFN

LFGVRIMGNGLVTDRNYEHWHKQRKVMDPAFSRT*LIGE

METFNEKAEELMEKLEEKADGKTEFSMLTMMSRVTLDVIAKVAFGLELNALRDDRTPFAD

AVTMIMKGMTEMRIPFVKYMPGKQKMIKEVQESVRLLRRVGKECIEKRREAIHSEKEMPTDILTQILKGDAL

EETRDDENILDNFITXXXXXXXXXXXXXIFTVMALSQHPEIMERVQAEVDEVL

GAKRDIEYEDLGKLKYLSQVLKESMRLYPPVPGTVRWTG

KETVIEGVRIPANTTLLFSTYVMGRMERYFTDPLCFNPDRFRKDAPKPYYSYFPFSLGPR

SCIGQVFAQMEAKVVMAKLLQRFEFQLVPGQSFKLLDTGTLRPLDGVMCKLMPRSSPKGF*

 

>CYP51       Gallus gallus (chicken)

MLSLLEVGGSLLERAAVGNPLSLLLAASAFALSLGYLFQLGYRRHVGADRTNH

PPHIPSSIPFLGHAIAFGKSPIEFLENAYDKYGPVFSFTMVGK

TFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNVVFLEQKKMLKTGL

NIAQFKQHVTLIEEETKEYFKAWGESGERNLFEAFSELIILTASHCLHGKEIRSLLNEKV

AQLYADLDGGFTHAAWLLPAWLPLPSFRRRDRAHRAIKNIFYKVIQKRRSSEEKEDDMLQ

TLLDASYKDGRPLTD

DEIAGMLIGLLLAGQHTSSTTSAWLGFFIARDKAIQEQCYAEQKAVCGDDLPPLTYDQLK

DLSLLDRCLKETLRLRPPIMTIMRLAKTPQTVAGYSIPPGHQVCVSPTVNQRLKDSWKDA

LDFKPDRYLRDNPAAGEKFAYIPFGAGRHRCIGENFAYVQIKTIWSTLLRLYEFDLVDGY

FPSINYTTMIHTPNNPVIRYKRRSL*