Ciona C-terminal alignment
 83 275
142       KKFNKVQIEQLHAIRRQQIKAFTEFPVDQKLIESLQFYICSSEIEVLIIDLLSGGVDTTS
136       --------------------------------------IC-SEKVILMTEFLVAGIDTTS
182       --------------------------------------VCYREIASLVSDMLGGGVDTTS
192       --------------------------------------VSQMEATTICLELLAGGIDTTA
40        ---------------------------------NRQLTDQQRRIAYGASDAFGAGFDTIS
25        -------KEHRLTYKHGVIRDIVDSFIAESIDHPEQSALNDDVIMALTTDVFGAGQDTMS
67        VDGVLKTFDNDDVTNVVASMTSEVLEKKSAGESREITESETKTIAALSADILGAGQHTTS
15        VEEVIQHFQPNKL-NDLASVMVSDLTNDPTENISNITEKDRNSIAAIINDLVQGGYHSLY
17A1fugu  ------------------------------GINAESVGLTDDHLLMTVGDIFGAGVETTT
91        ------------------------------------------------------------
36        ----------------------------------NTKLFENDQLKVYVRDLFIAGVETTS
53        ----------------------------------------EEELIVIVRDLFSAGSETSS
103       ----------------------------------------EDELVVIVRDLFTAGSGETS
157       ----------------------------------------EDELNVLFRDFFLAGSETTS
132       ----------------------------------------ELQLCVIVRELLLAGNETTG
66        ----------------------------------------ETQLLHCLGDMFIAGTETTT
32        ----------------------------------------ETELRHCLVDFFIAGTETST
57        ----------------------------------------EESLIVCVVDLFFAGTDTST
64        ----------------------------------------EESLILCVIDLFFGGTETST
24        ----------------------------------------EKQLQHAVVDLFIAGTETST
43        ----------------------------------------DESLMVCVADLFLAGQTTST
231       ----------------------------------------EEALLICVADLFVAGIETST
33        ----------------------------------------EESLRVCVADLFYAGTETST
16        ----------------------------------------EENLVNCLVDIYTAGTDAPT
21        ----------------------------------------HQNIIGFFSDMFLAGTKTIT
39        ----------------------------------------VQDIVGFFSDLFIAGTETLS
7         ----------------------------------------KPQLRYFLKDLFAAGTETSS
31        KRTLLGFINIHEKTYDSTNIRDFIDAFLLLKHRQLDESFNDKQLIHYIYDLFLGGTETTT
230       -------VKEHKATFDREDVRDFIDAFLKEAELSKEPSFNDTQLLHYLHDLFLGGTETTT
13        ----------------------------------DSLICKDRQLVHYVRELFKAGTETST
209       ----------------------------------------DGQLVQYVREMFEAGTETMT
2         ----------------------------------------DLQLLQYVRDLFVAGTETTT
20        ----------------------------------------DLQLLQYVRDLFVAGTETTT
4         ----------------------------------------DSQLLHYVVDLFEAGTETTT
11        ----------------------------------------DRQLVQYLREIFEAGTQTTT
27        ----------------------------------------YIQLLNYIRDLFDGGTETTV
18        ----------------------------------------DLQLIQYVRDLYVAGTETTT
86        ----------------------------------------EFQLLVFLRDLFIAGTETTT
23        ----------------------------------------DLQLIQYVRDLYVAGTETTT
208       ----------------------------------------DKELLGNVRDLFVGGTDTTV
5         ----------------------------------------DEQLHHYTRDLLVAAINTTT
69        ----------------------------------------ELQLLHLVRDLFVGAIDTTT
58        ----------------------------------------KIQLYHLIRDIFVGGIDTTT
61        ---------------------------NYILAGPTPSLENKTLVAGLIQDMLFAGSITTS
62        ---------------------------------------NKEQLFHYVKELFLAGTDTTA
41        --------------------------------------FTEKQLLYFMNDLFIAGTETSS
223       --------------KMTGSKKLIEGMLQNLQDWETGEVYNNQQLSCYLTDLFMAGTDTMA
68        ----------------------------------------YEQLVAMCRDLFMAGTDTTS
65        ----------------------------------------YEQLVAMCRDLFMAGTDTTS
34        ----------------------------------------DQQLVSMVRDLFLAGTDTTS
42        ---------------------------------------SEDQLIPLVRDLFMAGTDTSS
26        MRNYIKSHKETLDKNNPRDFIDAFLIASEEDKSEDTSF-DDEQLLYYIQDLFFGGTDTTS
140       SLIDQRKHSTVKPRVDLMQLMLNDQISVEDVAKGKSKGLTQLEITSNSVLMVLAGYDTSA
119       -------------------------------------GVTRTEMKGNALITLIAAYETTS
112       -------------------------------------GVTKTEMKGNSIIMLLAGYETTS
125       --------------------------------------LTEIEVTANSLLMMFGGFETTA
145       --------------------------------DESGEGLTDQEIREQVDTFLFAGHDTTA
184       -------------------------------------SNDISSLPDVIQDLIVAGAHSTG
141       --------------------RMAFLDVLLHAETEDGKTLSLNDIQEEVDTFMFEGHDTTA
115       --------------------RLAFLDVLLNAETEDGKSLSLNDIQEEVDTFMFEGHDTTA
149       --------------------------------DENGNGLTLKEIRDEVDTFLFEGHDTTA
121       --------------------------------DSDGKGLSDSEIRAEVDTFMFEGHDTTA
155       SVIDRRKCDIGQPAHNGTRKHFDFLDTLLKARDSDGKGLSDSEIRAEVDTFMFEGHDTTA
151       --------------------------------DENGIGLSDVEIENEVDTFLNEGHDTTA
148       ------------------------------------------------------------
158       --------------------------------DDDGKGLTEREIRDEVDTFLFEGHDTTA
130       --------------------------------DDDGKGLTEREIRDEVDTFLFEGHDTTA
129       TTVKDDVTGTSFNFNRRKGKMVDFLDILIQTKDQDGVGLTNDEINDEVITFFSAGHETVS
109       --------------------------------DQDGVGLKNDEINDEVITFFSAGHETVS
154       --------------------------------DENGEGLSDIEIRDEVDTFLFAGHDTTS
173       RSREYRQDLWNSLTKSKVTKRKEIFPIIDEIVTLHEQNGENKLLPKRLLPVLVASQVNTN
172       GVKESRANMWKFFTMDEIHKREMVYEMVEQYAKKLEEDQELEQLKKELYCVNWAAMSNTL
169       ATKKSRGRLFELLSRFDFENRDNVSELIKKVAAV----GSSEEKVRHLLIILWSAQANTL
164       --------------------------------------EFLKQRARHLMVVLWAAQANTT
96        --------------------------------------LGDLEIKEIAIELMFAGYYTSA
26B1fugu  --------------------------------------SKRKVLLESTIELIFAAFATTA
162       LKSKFNATDDELFGDSGGEFESVLLNILKFARREGETEIKLRNLQNLSLEFIFAGTQSLQ
111       KINKFVKAEIEQHRQNFDRKNPRDYIDCYLKELDQMNDQSELS-XMSIMDLFQAGTETTS
84        KINKFVKAEIKQHRQNLDPRNPRDYIDCYLNELNHMNDQSELS-KMSIMDLFQAGTETTS
228       KIHKFVKAEIKHHRQNLDPQNPRDYIDCYLNELNQTSDQSELS-XNVIMDLFQAGTETTA
1B1fugu   -----------------------------------------DYVIPTVGDVFGASQDTLS
46        ---------------------------------KNDPQYEESRVMKVVADLFGARVDTMT
180       ----------------------------------GQNGQGDASVAAKLRHADFSNSKSLE

142       NSAVFVLYLLSMNPDKQEVLRKEILEALKTG------KTDGKDLMRMSYLHACVLESQRL
136       NSAAFLLYALASNQEAQERLREEVREVNRMD------TIDGKLLHNMKYLQACLRETQRM
182       NAAAFMLYIMAVNPDKQEILREEIKTAL------QSGKVDGKSLQRMKYLHACALEAQRM
192       TAAVFTLFELSRNKEHQSKLRELANQE---------TDEGKNNSQFSRYLKSCIWESMRL
40        AMITWSIFYMAVFPEHQRKIREEIDRLET------SMFSLRHHGDVCPYTQAWLYEVLRH
25        TTMQWVFVYMMHFKECQRKIHAELDSVIGP-----GELPHISDRRRLPYLEAVMHEIFRH
67        TTFFWVINLLLCFPKVLNKLTEEVRSKLG------NRLPTLEDRTSLPYMDAVLTEVLRF
15        SMALWVVTYMIKYPEEVKKIENELNEVLD------DYLPTLHDQESLPHTMAFINEVLRC
17A1fugu  TVMKWAITYLIHHPQIQSRIQEELDSRVGM-----DRSPQLSDRGSLPYLEATIREVLRI
91        ------------------------------------------------------------
36        NTIQWSILALLYNPKYMDLMYNEVYEALG-----SDGVPCMKDREKMPVTCAFIQEIMRF
53        NSILWILIVLLHHPHHAKKCIQEIDDVMG-----PNGAPSSQHREKMPFTCAVIQETFRY
103       LMISWVLIMLLHHPEHAKKVIEEIDDVMG-----PNGAPSTKHRDRMPFTCAVIQETFRC
157       TNILWILLLLVHYPEHTAKVIKEIDTIIG------------THSSQMPFTCAFIQESMRY
132       SQLAWLLLALMHFPKWQDRIHQEIVDNIG-----ENGVLKLDDRKKLPCTCAFIQETLRL
66        NTILWALLALIHHPEIQEKLYQELLDNIG-----EQVLPSTDHRDKIPLFRAFTQEVYRF
32        NAILWSLLALIHYPNIQEEIHQELIDNIG-----EQVVPSIDHRDKLPLFRAFVQEIFRF
57        STVMWAMVALLNFPEIQEKLHKEIANATQ-----GEALPSLDHRDELPLLNAFIQELYRH
64        STVMWAMVVLINFPQIQEKLHKEIVTATG------EALPNLDHRNELPLFQAFIQELYRC
24        NTILWALLALIHYPETQEKLYQELLENIG-----EQVLPSIDQRDKLPLFRAFIQEIFRF
43        STIMWG-WWLILYPEI-------------------EALPSLNHRDDLPLLQAFIQEVYRC
231       GTVMWGMTVLINYPEIQEKLHKEIVNATG------ETPPNLDQMDELPLIQAFIQELYRY
33        STILWGMIALINYPEIQEKLHKEIVNATG------EEFPRLGHKDELPLLQAFIQELYRC
16        NVILWAIVTLLHKPNLQHLLFHEINNKTN---------SNEDLSNRWPLLKAFIQENFRF
21        SQLRWGFLIMVKHQDCQNKVRREIDDVIG---TVKLKHRKLKHRSIMPYTCAVVHELFRF
39        SQLRWGFLIMMLNPECQENVRNEIHAVIG------NGRARLSDRYRMPYTCAVIQEIFRF
7         STIRWALFYLIVNPDIQDKVHKEIDDVIG-------HNGVVRYDTKLPYTKAVLQETYRI
31        GTLRWAILCLLHYPEKQAKLRKEIIQVLG------DQEVTILKKHEMPYASAFIHEVYRF
230       STLRWALLCLLHYPQTQTKLREEINEVIG------DGKVSYSCKVDIPYTCAFIQELYRY
13        GTLRWAMLCLIHYPGAQEKIRKEIFDVLG-----NSTFPSMSDRNAMPYTSAFIQEVFRF
209       GTVRWAMLCLIHYPDAQKKLREEIFEAIG-----NNNRPSISDRKAMPFTSAFIQEVFRF
2         STLRWSILCMIHNPEKQEKLRKEICDVIG-----QDRVPAMNDKAQMPYTCAFMQEVFRY
20        STLRWSILCLIHNPEKQEKLRKEIYKVTG-----QDRVPAMSDKAQMPYTCAFMQEVFRY
4         STLMWSILCMIHNPEKQEKLRKEICSVVG-----QDRVPAMNDKAQMPYTCAFMQEVFRY
11        GTLNWAILCLIHYPQAQKKLRNEILDVIG-----NNNRPSISDRKSMPFTSAFIQEVFRF
27        STSRWAILCMLHYPETQKKLRNEIMTIIG-----PNTPASMSHKSDMPYTCAFIQEVLRF
18        VTLRWAVRCLIHYPEKQNKLRKEIFDVIG-----REKTPSMKDKAQMPYTCAFMQELFRF
86        STLRWALLVLLHNPGVQDKLRNEIHKVLG-----QSTTVSMAHRESMPYTRAFIEEIYRY
23        GTLRWAVLCLVHHPEKQNKLRKEIFDVIG-----REKTPSMKDKAQMPYTCAFMQELFRF
208       NTLRWTIIYLINRPEVQVQKKKEIDRVIG-----PDARPKMSHLDDMHYTNAFMHEMLRI
5         AAFGWCVVSLLRHPECQDKIWQEVDKVIG------DETPSCKHQENMPYMRSFIQEIHRH
69        ATLGWGIICLLHYPECQVRIQEEIDDVIG------CAEPDMSHHESMPYLRAFIQEVHRF
58        ATLGWGIICLLHYPECQMRIQEEIEDVIG------NSEPDMTHQEHMPYLRAFVQEVHRY
61        SQLLWVILFVLKNPACMHKMQNELDAVLG-DCENPTKSAISDKYDELNYTRAVVQEAMRL
62        TTLRWAILLIHYHTDVHEKIHEEIDREAS-------NPVKFEDMPNMPYTQAVIQEVFRS
41        NTNSWALLLLLKNPEVMKRLRDEIDSLGR--------EPTLEDEYKMPYTRAVMQEIFRY
223       TTVHWSLVFLAQNPQVQEKMAAEVKSVAG------NDVITTSMMDSMPYTRAVMHESSRL
68        STTSWIILFLCRYPEVQRKMQEEADQVLGS-----NGEPKMALAEKMPYTRFFFQEINRI
65        STTCWIILFLCRYPEVQRKMQEEVDQVLGS-----NGVPKMALAEKMPYTRAVIQEIARM
34        ATTCWIILFLCKYPDVQRRMQKEIDDVIGE-----NGIPKLALAERLPFTRAVIQEMGRI
42        TTITWVVIFLASFPDVQTRLHEELDSVLGQ-----NRTPSVSMEDKMPYMRAVIQETFRM
26        FTLTWTFLYLAMYPDKQEQLHAEIDEVLGS-----NGIVSMSCLDKMPYAQAVMQEIFRL
140       NALTLLAYNLATHKHVHKKVHEEIDQMLEK-----YGSLTYEALTSMKYLGMCLNETLRL
119       NAMVFLAYNLAVYKDAQHKCREEIEQVIAK-----HGGLTYEAVQDLKYMTQCLNESMRL
112       NAMVFLAYNLAVYKDAQHKCREEIEQVIAE-----HGGLTYEAVQDLKYMTQCLNESMRL
125       SAMVFLAYNLAVYKDAQHKCREEIEQVIAK-----HGGLTYEAMNDLKYIMQCLNESLRL
145       SAICWFLYNLACNPEYQDKCREEVKEVMEG-----RKDVQMFDIGNMTYLTMCMKESMRL
184       IVFNWAVLLLVLNKEEQDLCYREIMDNVGP-----TREISMSDRSKLRRVDAVMHECMRI
141       AAMTWAIYVIGRHPDIQKKIHEELDAVFGED---RGGTITNNQLQKLSYLERVIKECLRL
115       AAMTWTVYLIGRYPDIQEKLHEEIDSVFHDD---KEGVISNSQLQKLSYLERVIKESLRL
149       SGIAWCLYNLAKHPEYQQRCREEVLEEVGEKEKIEW-----EDLSKLTYLAMCIKESLRL
121       SGISWTFYCLAMHPEHQEKCFQEIEKVMADRTDIEW-----NDLSNLPHLTLCIKESLRQ
155       SGISWTFYCLAMHPEHQEKCFQEIEKVMADRTDIEW-----NDLSNLPHLTLCIKESLRQ
151       SGISWSLYMLAQHPEYQQKCRDELEEVLKDKEDIDW-----SNLTKLQYLTMCIKETLRI
148       -GIAWALYNLAVNVDCQDKCREELKSVVGDKENIEW-----EDLSKLSYLTLCIKESLRL
158       SGIAWSLYCLAANEEYQEKCREEIEQVVGSKDALEW-----QDLSKLPFVTMFIKEVLRL
130       SGIAWSLYCLAANEEYQEKCREEIEQVVGSKDALEW-----QDLSKLPFVTMFIKEVLRL
129       NAITWSLYTLASNLDCQTRCREEIKSAVGDKETLEW-----TDLSKLPYMTQCIKEAMRL
109       NAISWGLYTLASNLDCQTRCREEIKSAVGDKETLEW-----ADLSKLPYLTQCIKEAMRL
154       SGIAWAMFHLAKYPQFQTKCREELKEVLGNKDEIEW-----SDLPQLVYLTMFLKESMRL
173       PSSFWILYYLLKNSEALAAVKDEMEKVLQERSKNPGNNFTKEEMETMMTLESAINESLRL
172       LSAFWALYYILKHPEAMEAANVEIQRMLKETSQCVDGNFTRDDMAKMTVLDSIINETLRL
169       PALFWTLFYILNDKTARIDVLEEFEKHLRWPNLSDIQRMRKGDVDKLVLLDSCTKETMRM
164       PALFWTLFYLIANPDAKRAVLEEYEQL-RWPTMKDILQIERKDLDKLVILDGCLRETMRL
96        SALTSAILELARHPEVFSKLENELLQHGILREDSHMPELNLQNIHKLTYLDQVLKETLRI
26B1fugu  SASTSLIMQLLRHPPVLERLREELRARGLLHNGCLCPEGERLDTIVLKYLDCVIKEVLRL
162       CSCSLVTFHLSQNPQVNFECREEIKAAGLW--DTPLTEINVERIQSLRFIELVAKETLRV
111       TTLRWAILYMVNNPNIQSKVQQEIDDVLG-----FDRLPQYEDRMRMPYCEATVLEVQRM
84        TTLRWAILYLANNPHIQEKVQQEIDEVLG-----FDQLPQYEDRMRMPYCEATVLEVQRM
228       TTLRWAVLYMVNNPHIQGRVQSEIDNVLG-----FDQLPKYEDRSRMPYCEATVLEVQRM
1B1fugu   TALQWIFLVLVRYPDMQQRLQEEVDLVVG-----RQRLPCIEDQQQLPWVMAFIYEVMRF
46        VALAWMIVYWSTYQAAQERAQKEIDHFVK----NEKRLPRYSERNQLPYTMALIMEVERH
180       QHLLLFVSAVIPKAFASLITSFIIVMAGD-----DKEALRARARTDSKFLDRVLLEVERM


142       -LPFSIGTNRRYSKDIVLSG--------YKIPAGTV---VTMTSNIINNCSEEYFD-DPN
136       -FPFVNSSPRRFRKDLVLSG--------YLIPAGHP---HSDTSNTVNSRNPEYYD-DPN
182       -FPLTPGTSRRLPVDVVLSG--------YNVPAGTRL---LLLSNVAHHKNAEYFD-QPE
192       -HPLTYANMRKTETDLVLSG--------YKVPAGTTV---RYTSHLMNLKDEKYFP-QAD
40        ISVSPLLVPHYTVKQVEVNG--------TMIPAGVV----YNLLLIQADRDTRVWE-NPE
25        STFTSTTIPHVTTQDTVLDG--------HFIPKGIL----VFINQFGANHDPNHWV-DPD
67        SSPLSSTIPHSTLKDVKLAG--------HTIKRGTM----VIISQYAVNHDPQNWK-NPE
15        RPSLPLAVPHSATEDTKLGG--------YDISKDTM----VVASLYSANRDPKVWA-NPD
17A1fugu  RPVAPLFIPHVALSDTSIGD--------FAVKKGTR----VVINLWSLHHDEKEWE-NPE
91        ------------------------------------------------------WP-QPD
36        RTITPGAAPHSAMEDIKLNG--------YDIPSGTM----VVANLWALHNDPDTWP-EPE
53        RTVAPIGLQHYAQATVELGG--------LRIPQGQG----VYSNIWGVHNDPVAWP-NPS
103       KIVAPIGIQHYAQATVELGG--------YIIPQGTM----VYSNIWGVHNDPVAWP-NPS
157       RTSVPLGAQHYCQKTFQLNG--------YTIPKGTL----IYPNIWGVHNDPKSWP-NPS
132       HSIGSLNAPHKVSRDTEVKG--------YKIPAGTM----VMSNVFAIHTDPKVWT-DPE
66        KTIVPLALQHRANKDVEIGG--------YVIPKGTK----VFPNLHAVHHDPNIWK-NPS
32        KTLLPLSIQHRASHDVEIGG--------YVIPKGTK----VFPNLHAVHHDPNTWE-NPS
57        MTLGPFGVPHETTTDAYIGG--------YCIPKNTR----VITNIWAVHYDPNTWE-NPS
64        MTLAPLGVQHQTTKDADIGG--------YCIPKDTV----VLTNIHAVHHDPKIWK-NPS
24        KTLVPLSVTHRASDDVEIGG--------YVIPKGTK----VFPNIHAVHHDPNIWK-NPS
43        MTLVPLGVQHQTTKDVEISG--------YCIPKDTV----VFTNIDAVHHDPNIWK-NPS
231       MTLAPLSLQHETTKDADIGG--------YCIPKETL----VLTNIYAVHHDSNIWK-NPS
33        MTLIPLGIQHQTTKNVDICG--------YCIPKDTV----VFTNIHAVHHDPNIWK-NPS
16        NPPAPLSIPHQTNQGVKLDK--------YFIPKDTM----IISNIYAVNHDPKIWK-NPY
21        RTVVPLSLPRMNVADVTVGG--------YRIPKGTN----VIMNIWALHNDDCRWR-EPE
39        RTLGALSLPRTNVVDVEIEG--------CKIPKGSK----VILNTWAIHNDERNWE-NPQ
7         RTATPLGVPRRNTEDVTLMG--------YFIPKNTQ----IIPNLWWVHNDPEYWN-EPD
31        RTLFPLGLPHKTSHQVILDS--------YVIPQGTT----VCTNLWAVHNDPKVFD-EPE
230       RTLLPLSLTHKTNEKAMLGE--------YTIPKSTI----VSVNLWAVHNDPNTWE-EPS
13        RTLAPLGVPHKTTDTVNFAN--------YIIPKGTT----ILSNLWAVHNDPTVWN-NPR
209       RTRVPLGVQHMTTETVNFAN--------YVIPKGTT----ILANMWAVHNDPDVWD-EPS
2         RTLVPLSVVHMTNQDVVLNG--------YTIPKGTT----ISPNLWAVHNNPDVWD-EPS
20        RTLVPLSLFHATNDDVSLNG--------YRIPKGTT----VLPNLWAVHNDPDVWD-EPS
4         RTLVPLSLMHMTNEDVVLNG--------YNIPKGTT----VSPNLWAVHNDPDVWD-EPS
11        RTRVRTGVPHKTTETVNFAN--------YVIPKGTT----IVANLWAVHNDPDVWD-EPS
27        RTLVPLSVPHKVNEDATVNG--------YTIPKGVT----VSPNMWAVHNDPDVWD-EPS
18        RTLVPLGVPHKISNDVQVEG--------WSIPKGTW----IIPNLWAVHNDPDVWD-EPS
86        RTLTPLDLFHETSGELNISG--------YKIPKNTV----IIPNLWAVHNDRDVWD-EPS
23        RTLAPLGVPHKISNDVQVQG--------WSIPKGTW----LVCNLWAVHNDPDVWD-EPS
208       RTPGPLGLAHRTTEPTKLMG--------YDIPEV------FITNFWAVHHDPKLWD-QPE
5         RSIATLNLPHRTVRSVRLCG--------YDIPKDTP----VLTNIWRVHNNQNVWK-NPH
69        QTIAPLNIPHCVTEDCVLFG--------YHIPKSTP----VMSNIWRVHNDPKYWE-NPE
58        CTIAPFSIPHCVTEDCVLFG--------YHIPKSTP----VMSNIWRVHNDPKYWK-NPE
61        RCIAPTSMFHKATEDTTIAG--------YFVAKDTV----IMPNLYSVHHDPITWAPDPE
62        RPIANFGTMRKTTAVGKVGG--------YRIPKGSI----VMPNIWAVHHNPQRWK-DPH
41        RPALPCNIIPRKTTTSIELNG-------HSIPAGMP----VIANLWSVHHDPVTWAPDPE
223       RPVFPLSLRHQATSDVTVKD--------YVIPTGTS----VVANLWAIQNDPKWWK-QPS
68        RPNVPLSVPHYSSKDTMVMG--------YKIPKDTI----VLTNIWGIHHDEKLWK-NPY
65        RPTLPLSVPHCTTQDTMVMG--------YKIPKDTI----VLTNIWGIHHDEKLWK-NPY
34        RPNVPLAVPHCASRDSTLMG--------FNIPKDTI----IMTNIWGIHHDEKTWK-DPY
42        RPPLPLSVPHVAQCNTTLMG--------YRVPKDSI----ILTNTWGIQNNPKFWV-DPD
26        RPLVPLSMPRKTLSRITLMG--------YDIPKGTV----FMPNIWSVHHNADRWP-NPE
140       YPPIAVNSRIPNRDITINE---------VFLPKGIQ----VIVPVYGMSRDEEIWE-EPL
119       YSLVPANGRYCERDITING---------VTIPKGTL----VNIPVFGMGRDEEFWD-DPL
112       YSLVPANSRYCERDITING---------VTIPKGTL----VNIPVFGMGRDEEFWN-EPL
125       YPPAPMNSRYCERDITIHG---------LTIKKGIT----VQIPVYGMGRDEEFWE-DPL
145       YAPVPFIGRKIKNKLNVHRPNGASD---VTLDADVT----VIPHLFTLHRNPEIWD-DPE
184       GTVLPLVAHATARDTTIHG---------YNIKAGTE----VIYNNWFINRNEKVFP-DAE
141       YPSVPFYARVLSEDCKVGD---------YMVPKGTQ----TVIFAHTIHHHPYVWE-DPE
115       YPSVPFIGRVTTEECIIAD---------HVIPVGTQ----VALFIESMHRNPAVWP-DAE
149       NPPVFCVGRELNEDLTFNDKYTPCKK--MKVESGNT----VLMQIMSMHRNPHVWE-NPE
121       YPPVPIIFRKLNKDIEVDG---------KTIVKDTN----VVLHIYALHHHEEFWK-DPH
155       YPPVPIIFRKLNKDIEVDG---------KTIVKDTD----VILHIYALHHHEEFWK-DPH
151       RPPVPAISRQLDQPLTFKSKTHNVPP--TTLAKGSF----AGVQIFSLHRNVHVWE-EPE
148       CPPVPFIGRELNEPLKFRSKLKEPNE--TTIDAHSN----IALHIFTLHRNVHVWD-SPE
158       YPPVFAVARRTEQPVKFPRGFGRDQL--NVVXAPLN----IGIPIMTLHRNEQVWE-DAK
130       YPPVFAVARRTKQPVKFPRGFGGDQF--NVVDAPLN----IGIPIMTLHRNEQVWE-DAK
129       FPTLHVVGRQLTEDVTLSHRFNDWKP--VTLPKGSS----IGVNIFAMNRNPHIWD-EPE
109       FPTLHVISRQLSEDVTLSHRFNDYKP--IIIPKGVC----VAVNIFAMSRNPHIWE-EPE
154       RPPVYAVGRYLEHPITIKDKNTKRD---TVIPAGTN----VSMHIFTLHRHPDFWD-EPS
173       SISGGMLRKAATEYRLEIPDYGQT----YTIRENDM----VLVWTQVNQMDPEIFE-EPE
172       DISSSLLRQALQDYNLKVVSADRS----YKIRKGDK----LMTLFQLTHYDPEIYE-QPD
169       TGSSLAARRAHADTTVTLASGQE-----YKIRKGDY----TSYFAPVTHQDADIYD-KPE
164       TGASMSIRKATRDESIKTSDGKQ-----YSVRRGDY----TAFFAPVTHMDEDIFE-KPQ
96        RPPVLGAYRRAKKTFQIGD---------YRIPKGWT----VIYNIRDTHELEFEHMTGKC
26B1fugu  FTPVSGAYRTAMQTFELDGV--------QIPKGWS-----VMYSIRDTHDTSTVFKDVDV
162       TPTIPGAVRVALKTFELGG---------YQIPKGWQ----IIYSIRLTHEEAAGKVGSKC
111       -ATIAPIGLHCSEEDQMLGG--------YRIPKRTS----IMACYHSIHFDPKFWK-NPN
84        -ATIAPIGLHCSEDDQVLGG--------YHVPKRTS----IVACYHSIHFDPKFWK-NPN
228       -ASITPFGLHCSEEDQKLGG--------YHIPKHTC----IMPSYHTIHFDPKFWK-NPN
1B1fugu   -TSFVPLTIPHSTTTDTTIMG-------YTIPKNTI----IFINQWSINHDPTIWS-HPE
46        CSFVPFTLPHAPAQDTMLNG--------YLIPKGTM----MLISMRSINHDTAVWD-SPA
180       WPPLFAGRRLVRRTTTLES---------YDLPKDYA----IMYVTHAAHRDPEVFP-EPN



142       SFKPERWIQVDNKAKDRMRFAM------AGSFGHGTRACPGRKFALQEMKYLLISVLSRY
136       TFIPERWLETKS-FKPYIRFIM------SGPFGLGMRMCPGRKFSIQELQLLLITLLSNY
182       NFLPERWLERKH----KSKFAM------IGSFGMGARACPGRKFAMQEVHYLLISLLSRY
192       EFLPERWLDRKSENRCKEQFT-------FTPFGHGARQCPGRRIAEQELDLLFRQLIRNF
40        QFEPERFLARDPTTGGARVVAS--ETSKILNWGAGKRRCPGAELSRHELFIYNANLVKLC
25        KFIPERFLDGKGNLISRPH-------DRYLLFSTGARKCPGDELSRMLILHFMATMFALC
67        NFDPERFLTKNEGGEIIFNES---LSEKVLAFSIGERKCPGSQLSRMLLFLATTLLVQVS
15        QFDPSRFLAKDDLGVTVLDET---KVEQVFTFSLGDRKCPGEDIGRSFLFLTTAYLAHTC
17A1fugu  RFDPGRFLNSEGTGLVIPSSS-------YLPFGAGVRVCLGEALAKMELFLFLSWILQRF
91        KFDPHRHLDSAKKFISSSE---------IVPFSVGARYCMGRETAQTEIFVFVVALLQKF
36        QFNPHRHIDSDGKFIHSPK---------ILPFSIGPRYCMGEGIAKAEIFIFLTSLLQKF
53        EFDPYRHINKDGKFVPSNN---------IMTFSIGPRSCPGEALAKLEIFMFVTKILQKF
103       KFDPYRHISKDGKFFTSNN---------IISFSTGPRSCPGEPLAKMEIFLFVTKILQKF
157       KFDPYRHIDEKGNYRNSSN---------VIPFLIGPRTCVGEALARQEIFIFLVKILQKF
132       TFDPSRHLNETGSFINSSK---------MSPFSLGPRQCIGKTIAENKMFLYFGNICQKF
66        EFNIYRHISKDGKFIPSKR---------VVAFGMGARSCLGEKLAITEVFLFLANIIKRF
32        DFNIYRHVDKHGKFIPSKK---------VIPFGIGARSCLGEKLANVEVFLFLANIIKRF
57        EFNIYRHIDEDGKFVPSKK---------VIPFGIGCRSCLGEKLARLEVFHFLANIIKRF
64        EFNIYRHIDQDGKFIPSRK---------MIPFGIGCRSCLGEKLARSEVFLLLANIIKRF
24        EFNIYRHIDKDGKFIPSKK---------VIPFGIGCRSCLGEKLARIEIFLFLANIIKRF
43        EFNIYRHIDKDGKFIPSKK---------VIPFGIGCRSCLGEKLARIEIFLFLANIIKRF
231       EFNIYRHIDKEGKFILSKK---------VIPFGIGCRSCLGDKLARNEVFLLLANIIKGF
33        EFNIYRHIDEEGKFIPSRK---------VIPFGIGCRSCLGEKLARIEIFLFLANIIKRF
16        EFNIYRHIDTDGKFVPSTK---------VIAFGIGCRSCLGEKLGRLEIFYFLANMIKRF
21        RFIPERHLNADGKFMKPKN---------VLPFGVGARSCIAEHLARNKIFLFLVSTLKNF
39        KFIPERHLDKDGNFINSKK---------VLPFSVGVRSCLGEQLARAEIFLFFVATLQQF
7         VFKPERHLDEEGNLIMSNR---------VIPFSIGARHCLGENLARTEIFLFLVSILQKF
31        EFKPERHLYGNGEFGRSPY---------VIPFSVGPRHCLGEQLASMMLFIYLVSLVRSF
230       MFKPERHLDESGHFVQSKH---------VIPFSVGPRHCVGEQLARMEVFIYLVSMVQKF
13        QFKPERHIDDKGKYIQSNH---------VIPFSVGPRHCLGEQLARMEIFIFLVSMVQKF
209       KFKPERHLDDKGNFVQSNH---------VIPFSVGPRHCLGEQLARMEIFIFLVSMVQKF
2         KFKPERHLDDKGNFVQSKH---------VIPFSIGPRHCLGEQLARMEYFIYLVSMVQKF
20        KFKPERHLDEKGNFVQSKH---------VIPFSVGPRQCLGEQLARMEIFIFLVSMVQKF
4         KFKPERHLDDKGNFVQSKH---------VVAFSVGPRHCLGEQLARMEYFIYLVSMVQKF
11        KFKPERHLDDKGNFVQSKH---------VIPFSVGPRHCLGEQLARMKIFIFLVSMVQKF
27        KFKPERHLDDKGNFVQSNH---------VIPFSVGPRHCLGEQLARMEIFIFLVSMVQKF
18        KFKPERHLDEKGNFVQSKH---------VIPFSVGPRHCLGEQLARMEIFIFLVSMVQKF
86        KFKPERHLDEKGNFVQSKH---------VIPFSVGPRHCLGEQLARMEIFIFLVSMVQKF
23        KFKPERHLDEKGNFVQSKY---------VMPFSVGPRHCLGEQLARMEIFIFLVSMVQKF
208       EFIPERFLDKDGKFVKNAN---------LVPFSMGSRYCMGETVARMEFFLFVVTMLQRF
5         EFRPDRHLDSNGNFVSSNN---------VIPFACGYRRCLGEQIAKAEIFLFIVNIVKRF
69        KFSPERHLDSEGRFVPSNR---------VLSFAVGHRSCLGVQLARVELFLFYASTLKKY
58        KFSPERHLDLEGRFVPSNR---------VLPFAVGHRRCVGEQMAKVGLFLFWASFLQKC
61        SFRPERHLDSDGSFVNSDH---------VIPFSVGWRRCVGEKIARTEIFAHLVSIFKHF
62        LFKPDRHIDQNGKFVKSED---------IIPFNVGQRSCLGMQLAKMEIFIFLVRMMQRF
41        TFRPERHLNRDGEFMTSDH---------VMPFSVGLRSCIGRNLARNELFIFLTSILRRF
223       EFRPERHVTEDGGFTKSEK---------IVPFSIGPRYCLGSQIAIYQQFIFLTNLVRGF
68        DFNPERHLDSNGKFIKSSK---------VIQFNIGLRSCLGQQLANMELFLVTVSIFRQF
65        DFNPERHLDSNGNFVKSSN---------IIQFNIGLRSCLGQQLAKMELFLLTTSLCRHF
34        KFNPDRHLDAEGNFVKSNH---------VMQFNIGLRSCLGQQLARMELFLITVTLFRKF
42        TFKPQRHIDDLGKFIKSPN---------VIPFNIGSRNCLGQQLAKMELFITIASLCRRF
26        DFMPERHIDSEGKFVKSKE---------IIPFSLGPRNCLGIRLAEMEHFMFMIGLLQKL
140       KFKPERMEDMRSVDSMI-----------FQPFGGGPRGCIGMRFAVLEIKLAIAKILQDF
119       TFNPDRMLDMNEIDPMI-----------FQPFGAGPRNCIGMRFALLEIKITFAKLLQKF
112       TFNPDRMLDMNEIDPMI-----------FQPFGAGPRNCIGMRFALLEIKITFAKLLQKF
125       VFKPERMLDMNEIDPMI-----------FQPFGAGPRNCIGMRFALLEIKITFAKLLQKF
145       VYDPERFNTKNASRLHPYA---------YIPFSAGPRICIGQNFALVEMKLTVAKLLLNY
184       KFNPDRWIKKDGSFRKELLQH-------FFPFGIGKRSCAGESLARANLFIVVATLLQRV
141       KFDPDRFLAENCVKRHPYA---------YIPFSAGPRNCIGQKFALMEEKVILSKLLHNY
115       KFDPDRFTAENCVGRHPYA---------YIPFSAGPRNCVGQKFAMMEEKVILAQILRRF
149       VYDPERFSAENMKNRHSMS---------FLAFSAGPRNCIGRNFAMNELRVVIGQTLRQY
121       IFDPSRFTQENMKSMNSYA---------YVPFSAGPRNCIGQRFAMNEIKIAVAQVLSKF
155       IFDPSRFTQENMKSMNSYA---------YVPFSAGPRNCIGQRFAMNEIKIAVAQVLRKF
151       VFNPDRFTQDNIKKRSPHA---------FLPFSAGSRNCIGQNFAMNEMKIAVGQIIRKY
148       EFIPERFKPENMKGRSPHA---------YLPFSAGPRNCIGQNFAMNEMKIAIGQTLRRF
158       VFDPYRFSTENCAKRSPYA---------YLPFSAGPRNCIGQNFAMAELKTVLVRTLLRY
130       VFDPYRFSTENCAKRSPYA---------YLPFSAGPRNCIGQNFAMAELKTVLVRTLLKY
129       KFDPERFSPDNTANRSPHA---------FIPFGAGPRNCIGQNFGMQQIRVVLSKVLRKY
109       KFNPDRFTPENTSKRSPHA---------FIPFGAGPRNCIGQNFGMQQIRVVLSKVLRKY
154       KFDPERFTKENIAKRPAFA---------YVPFSAGSRNCIGQNFAMNEMKISLAHVIRNL
173       VFKYDRFLNEDGSLKTNFYKDGKLVKYAFQPFGDGSSKCPGRYWAVLELKQLVVNMLLYY
172       QFKFDRFLNSDGSPKTDFYKKGKVVKFFLQPFGSGVSKCPGRYWAVTELKQLVILLLLYF
169       EYRHKRFL-LKSRTQFSKNGKRISPSTSIMTFGYGAVRCPGRHIALMEIKFLTLVLLRHF
164       DFVHDRFL-LKPRSRFTKNGQRVAVSRAIMTFGYGVTRCPGRHIALIEIKLAVLAMLGHF
96        EFDPEHFAPDANDKKFR-----------FIPFGGGPRVCIGQEYARIIMKVSLIEMIRCN
26B1fugu  FDPDRFSQERGEDKEGRFH---------YLPFGGGVRSCLGKQLATLFLRILAIELASTS
162       EFEPGKHFTSTCKNTDPFA---------FLPFGKGPRMCAGKNYGMLFLKVLIFELVRTA
111       EFDPCNFLDSNKKVCIPDA---------FMPFGGGLRICVGMNIAKQELFLFFVAILQKF
84        KFDPCNFLDSNGKVCIPDA---------FMPFGGGLRICVGMNIAKQELFLFFVAILQKF
228       EFDPCNFLDPDGKVGTRDA---------FMPFGGGLRICVGMNIAKQELFLFFVAILQKF
1B1fugu   TFDPNRFLNPSGSLNKDLT-------SRMLIFSMGKRRCIGEELSKLHLFLFTALIGHQC
46        QFRPERFLLDQSGGFNSALA------EQVMLFGAGRRRCAGEALGRMQIFLYSVLFLRKC
180       SFNPDRWITCNAGQEDL-----------VLCFGSGPRCCVGTDLIRRILRDVASRLLQNY



142       KVEYHYKPMKINFLLVSTPSQPPKFTFKQL-----
136       RVEYHHDPIKVAFRLVSFPSQAPQFKFTKLKN---
182       KVEYHHIPIKPHFRLVTVPSEKPQFTFIPL-----
192       NINYEHEDIKTKVRLFNAADRPARFSFTPISKPIT
40        YIEQAVEGIEPAIPWPCTPGISTKPKAFRVKVTQR
25        EVSSDPQKPATLDAVYNLSMRPKELRTIVRSNKLA
67        DLSADLERPPTAAAEYGLILRPKHLSIKLTLREHW
15        KLKPDPAKPPTFQTKPGSITRPKDFGVQLNVKKCW
17A1fugu  TLTVPSGHSLPSLEGKFGVVLQPTKYKVNATPRPG
91        KITRDPTLKWPIHMEDGIQSALCCPSRYKIILN--
36        TVSRDPNAVYPEEIEQGIVSAMSCPHRYNIILTAR
53        NVRASPNNPPSL-DGVNCLQFTPLSCEVILTER--
103       EVKAPPDKLPSL-VGVNCLLFSPESCEVILTER--
157       EVEPVPGETPSIADGVNSVVFSPHSFNLILQER--
132       RIVSETPTPITLHEGQSGFVFSPKEHKVIAIAYSS
66        EILPDPESKELPILKDGVNSLLYVPYRFKVVVKPR
32        EILPDPESKELPDFKDGINGFIYVPYRYKVVTKPR
57        EILPDPESKELPDYRDGVNGFVYVPYRFKLVAKPR
64        EILPDPESKELPDYKDGINGFLYVPYDYKLVDKPR
24        KVLPDPKSQDLPEFKDGVNSIIYVPYRFKVVAKPR
43        KVLPDPESQDLPPMDDGITGFGFFPFPFKAVVLPR
231       EILPDPESKELPDYKDGVNGFLYVPYDYKLVAKPR
33        EVRPDPDSEPLLPIDDGITGFGFLPFLFKAVVLPR
16        EILPDPGSKDLPPINEGGNSILHLPIHFKVVFKPR
21        --TLSVPNGDSPSLDAGSNGTIFIPSDYNIVAQYR
39        ELKFDPNAQVPSLDDASNGVIFSPNPYTMIAERIN
7         TVLPNPEDPNPPLECSPGIVNSPHKYPLIMKER--
31        EFLPDPKLNGLPDIRSGASGPVFLPKSFNVVAREL
230       EFLPDRNANELPDIEKGSNGPAFVPQMFDIVAKVI
13        EFLPDPNKTDLPELDDGVNGVAFVPYPFKLVAKEI
209       EFLPDPNEPDLPEINDGVKGNGFFPYPFNFVASEI
2         EFFPDPNEPDLPDVEDGSSGVVFVPLRFKQIAKIV
20        EFLPDPNEPNLPEIENGSCGTVFVPFRFKQIAKMK
4         EFLPDPNEPNLPDIEKGSNGAAFVPLPFKQIARVV
11        EFLPDPNEPDLPEIDDGVIGNGFFPYPFNFVANEI
27        EFLPDPNEPDLPEINHGTNGAAFVPLPYKIVANQI
18        EFLPDPNEPNLPEINHGVNATVFVAYPFNIVANQV
86        GFLPDPNEPNLPEINHGVNATAFVAYPFNIVANQV
23        EFLPDPNEPQLSEVQQGVSGFMCVPHPFKQIAKEV
208       HLLLPTDDSEKITEECLRSGQFLIPPSHNMRVKER
5         HLVVDQVTGPPTLEKDPKGAVNTPAPFRFSVRARK
69        EFQIDPEYGLPDWSNDRSGTVKTPKKFSVLLKSR-
58        EIHIDSDFGLPSWKKEPSGTVRSPQEFTVKVRNRL
61        EVALHPDDVGVDMEGVPGPILRPVSYRTQFTSR--
62        NFKLATDKEKLDLNGQYIFLHYPPAFDVSVQLRS-
41        NLEFADGCYVDDMTGESGLLLHPPSYKVKGSLRA-
223       RFRFDQAKVEPDLTGLMTSVLAPVNVHLVAEER--
68        SFSFNPGDKIDMEGESVIALRPYSYRVIDCYVPIF
65        SFSV--VGEVDMEGESMVTLRPCSMEVVATKRA--
34        FIELEPGCDIDMEGESLVSLRPYPFKVLLTKRI--
42        WFTLPTGETPDLKGESTFILRPFPFNVVATKRV--
26        HFSLPEDQPPPDVRGSSFVVLLLPPDFNMKITTR-
140       NLDVCENTPKPPVQLEFKSTTLKPKGDIYLRVTPK
119       YLDVCEDTPAPPLEVTFKSGMRPKEMIHLKVTAVE
112       HLDVCEDTPAPPLKVGFKTSMKPKETLYLKVKALE
125       HLDVCEDTPAAPIDVSFKSGMRTKQDLFLKVTARE
145       EFYVDEDIPKPQPIPNVVLRSQNGLYVKFRKI---
184       ELLPPDETASPEMLPEVKHQFGLLAECKPFLMRVR
141       FVVSHDKKEDLVINGDLILRSSTPLNITLEARK--
115       SLVSHEKEEDLKKQADLILRSSKPLNITLTPRV--
149       KLWCDDDTPEPKMQPNIILRSANGIHIKFKPV---
121       QLKPDLS-KKIQHSVDVIYRATTGLYLKAERRV--
155       QLKPDLS-KKIQHSVDVIYRATTGLYLKAERRV--
151       ELYIDDDTPDTVMETALVLRSTNGIMIKIRKI---
148       KVIPDESSPKPSITPQVVLRPKDGIFIKLMKI---
158       KLYVDNQCPDPKMSPMIVLKSLNGIHIKLKKI---
130       KLYVDNECPDPKMSPMIVLKSLNGIYIKFRKI---
129       EVYVDETLPKPVMVPGVAMQPKNGVYIKVRKLSKE
109       EVYVDETLPKPEMSPGVTVQPKDGVFIKVRKLTTQ
154       RLYIDDETPXPKMQPRLILQSSTGIFVKIEKLERQ
173       DIQLID-SQEIKMDKGRVGLGALNPTKDALMSIRR
172       DFKLINPKQEIKMDQIRVAFGSLPPNIDPQVQFKR
169       DIKLVKNYSRQSEDYPQFDLTHLGFGVMPPSRDVD
171       NVQFVDSNTKP----PSFDLTHLGFGVMPPDTDIE
96        SSWKLANKTLPKMVAIPTLHPKDGLPVHLQPRKTV
26B1fugu  -RFELATRQFPRVITVPVVHPVDGLKVKFYGLDSN
162       DISLEGKCKIIEVPMTRTDKSVKIKFTSIKKLKPE
111       SLHLPDGVDHLDEESGSGITLAPKIYQVKIKRRA-
84        SLHLPDDMDHLDEKPGPGIILAPKIYRVQIKRRA-
228       TLQLPDDVKSLDDEPIPGMTLAPKPFRVKIKIRS-
1B1fugu   HITDDPAKPTTMDYNYGLTLKPRGFYVALTLRGDM
46        TFRRSDKDGHVLPESLAGISLIPQTMCVSISRREA
180       EWSLAPPNQDTSYKYLPVARPAVQPSIAFSSYLTN