XX = frameshift, XX = phase 0, X = phase 1, X = phase 2, XX = not checked

XXXX = EST support, XX = bad boundary, XX small deletion in alignment

N-term exon 19-22 aa occasionally dropping to 15aa (in CYP516).

55 592

513F1     -------MILSLLFLFVITLYFLIPSR-----ISKIN-KNIPGP-IGYPIVGNLFQINK---

513G1P    -------MIYFIIIVLIIFLIIKNL----NNRIYQIN-SKIPGPGFSLPILGNLHSMNN---

513E1     -------MNLYISILILIISLIIFFKN--NNRISKIN-SKIPGP-IRLPIFGNLLQINK---

513A1     -------MNYLVGLVLIFT-IFYFFLQ---KNDKNMN-SKIPGP-KGIPILGNLLSMKG---

513A2P    -------MNFLIILINIIIVLTTIIFLK--KIIKKKN-KYIPGP-IGLPILGNLLSLKG---

513A3     -------MTSLTLYLIIFSIILYLFVN----RNKRKN-LKIPGP-NGIPIFGNLLSLSG---

513B1     -------MNLLVLSVILAIIIYLIFKRNYKYSPSKIN-SKIPGP-IGLPIFGNILSLDNK--

513C1     -------MNYLVLILVSLVSIYFLFIKN-QDRKKKIN-SKIPGP-KG-FLFGNLIELARTK-

513E2P    -----------------------------KNRINKIN-SKIPGP-IGLPIIGNLHQLKNNP-

513E3P    --------------------------------------------------------------

513D1     -------MGISSIIIILFIIVLLKKLIKKEDRIHRIN-KNIPGP-KSKLLVGNLFDLKG---

514A1     ----MNTIFTIILTITILVLSLILKDLLFEGRIKKIN-KLIPGP-STIPVFGNLLQINA---

514A2     ----MNLIYTIILTIIILVLIISIKDLFFEDKIKKIN-KSIPSP-PTIPIFGNLLQINS---

514A3P    --------------------------------------------------------------

514A4     ----MNTIFTIILTITILVLSLILKDLLFEGRIKKIN-KLIPGP-STIPVFGNLLQINA---

515A1     ILGIILGLFIYIYLINIKFFNRAVPSSLLVGENKLKC-KFPSGP-LILPIIGSLYKLSL---

515A2P    --------------------------------------------------------------

515B1     -----------MATLLLVIIFMITFIIYKNFDSKRKN-KYPPGP-INLPFIGGLYKLKP---

516A1     --------MIILLLSIIIFILYIVKIFKNKSCCGNEI-ILPPGP-ISLPFIGNLHQLAI---

516A2P    --------------------------------------------------------------

516B1     ---------------MYLILSLIIFLAYVAFHKKRTN-GMPPGP-FPLPIIGNLHQLGK---

516B2P    ---------------MFLILSLIIFWAFVAFHKKRPK-GLPPGP-FPFPILGNLHQWGR---

508A1     ---------MALFEIIISLFVVYIIHNAISKYKKIHV-NELCGP-TPIPILGNLHQFG----

508A2     ----------MIFGIIGYLFLIYILHNAYSKYKRLNE-NQLPGP-FPIPILGNIYQLT----

508A3     ---------MEFLKLILFLIIFYIIHNTYIKFKKINK-NELKGP-IPIPILGNLYQLTS---

508A4     --------MIMLIKVFVLLLVVYILHNSYKKYKKLDK-NELKGP-TPIPVLGNLHQLS----

508C1     -----------------------MGPWGYIKNKRIHK-NEAKGP-IGFPLIGNMIQIGK---

555A1     -------------MIIIVIVVFLFYFSFLNLNLNPKK-KRPPSP-ITLPVIGNLISLLN---

508B1     ----------MLFNIFLYLFIFCIVSSGIKKYKKIHK-NELSGP-FPIPLLGNLHQLGK---

508B2P    -------MIETFVFIFISILMFQFFIKCYILYRPKFK-NELDGPSFPIPFFGNNLQIGK---

508D1     ---------MVYLNNIFIFFIIFFIYSFVKKNKKSTKENDLKGP-IALPIIGNLFGLRN---

508E1     ---------MNIINIVIFLIIFYLFKSNYKKYIKKNK-FEVNGP-FPLPIIG--FTSNY---

554A1     ---------MDLLLFIFFLI-LFYYSVKYYKADNQNS-LSLSGP-TPVPILGNIHQVGK---

517A1     ---------MEIINVFLFLIILFLVKDFVKKNKKIHT-KSPSGP-IAFPILGNVVQIRFWEL

517A4     ---------MEIVNVLLFLIILFLVKDFVKKNKKIHT-KSPSGP-IAFPILGNVVQIRFWEL

517A3P    ---------MEIVNVFIILIILFLVKDFVKKNKKIHT-KSPSGP-IAFPILGNVVQIRFWEL

517A2     ---------MRILIIIILIIIVFLVKDTIKKNKKVNS-KSPCGP-FAFPILGNIIQYFFYQI

518A1     ---------MSILIILIISIIFYLIFDFLYKNFSN---RQFKGP-LALPLVGSLLHLKDDT-

518A2P    --------------------------------------------------------------

518B1     -----------MLTNIIILIILYLFYDFCYKNFKY---RNYGSP-WALPVIGHFIHVIN---

519A1     --------MESIINLIFYIIIFLILIDFLKKNISFRK-NEPPRGGVAFPIFGDLPKLGE---

519E1     ---------MGIGLIILYLLIGLLAYDFTKKNKKISK-NDPKQP-LAIPVLGHLHLFGS---

519B1     ---------MNLINLILYFILFWIVFDFIRKNRRISF-NDPPSP-WALPIIGHLHKLSL---

519D1     ---------MNVFVLTVFICIIYLLFDLIKKNKKLKD-EPPTPK-LALPLIGHLYLLGD---

519C1     ---------MNILLLIFYFLVCFLIFDFIKKNKVKKY-DVPTLS-YALPIIGHLYKLGV---

519C2P    --------------------------------KIKKN-DIPTLP-FALPIIGHLYRPGS---

519F1     --MEILTFIIYLITFFILFDFKKKKFKKNKRYSKSPN-KEANGP-WSLPIIGGLHLIGD---

519G1     --MNYLLIIICIIFFSLFFDF-KIRKNWNLNFKRLFK-KDVNGP-WSLPIIGGIYLIND---

519H1P    --------MFIIYFIFLFLLIISLFIDFIKKNLKKSN-NDPPGP-ISLPLLGNLHNLTKN--

525A1     ----------MEDYSVQSVVSLVVFLLVLQILKYYNK-TNKNNK-YNLP-KGPSFLKCQEEL

521A1     ---------MILLTLLYLIIFYIIIDFIKKNYKTKNQ-LPSPLG-IALPIIGHLHLLRT---

522A1     ---------MILTIVIIILTVIFVNKYLLNNGGKNDL-RKVQGP-FNLPLLGALYAFDKE--

CYP51     --------------MIGTIAVLVIAILVIFAFKKSPS-NIPPIV-ETIPFIGCFYQFAKN--

524A1     ----------------MKTPTKYFIIFILLAALAVFK-GSLPGPSFVPPFFGMLFQLIFT--

556A1     -------------MFLTSILYTIIIILIFYKGLEYLI-EKRSFP-LVHPIKGVMNGTKPYFI

 

513F1     ---NVVKSIDGFYKEFGP-VYRLRMGNIETVVLTGIDTLEESFLFNKHSFVDRFVKKSRK

513G1P    --NEPHLKIHEWYNKYGN-IFRIKMANIETVVLTEKPLLKKAFIDNSNLFKKRYLYLNKN

513E1     ---DPHIQFQKWYEKYGV-IYSIRLGNIETVVFTGYPIFKKAFIENSQIFAPRFQHLSRF

513A1     ---DLHLKLQEWYKQYGV-IYRIKMGNVETVVLTEYPIIREAFIGNSNSFVNRFQRKSRL

513A2P    ------ISFQEFYKQYGP-IYRIRMGSIETIVLTESSTLKEAFIGNSYIFENRFQKERNN

513A3     ---EMHLTLQEWYKTYGS-VFSIRMGNIDTVVLTEYPTIRKAFVDNSLAFASRYQLKSRV

513B1     --NGIHTTFQKWFKIYGP-IYSVNMGNKSAVVLTGFPIIKKAFIDNSEAFAPHYTFESRY

513C1     --KNLHLKYLEWFEKYGP-VFRVSIGSLETVVLTGYPILREAFIDNSDTFTSRFQRENAR

513E2P    -----NKVFKKWYKKYGP-IYRIRMGNIETIILTGYPIIKKSFIDNSNVFQKRYEYRSKI

513E3P    ------------------------------------------------------------

513D1     ---QVHEKLKEWYEQYGS-VYRIEFGSVSTVVLTEYATLKEAFVDNGEIFQSRFQRKSRT

514A1     --KDFPKSVNDFYERYGK-VFRLRLGSVEIVVLTGPEVIDECFNKKHREIFKERYIKFSR

514A2     --KDVATCFNDFYKQYGK-VYRLRLGSVETVVLTGGDIIDECFNKKYRDFLKARYVKFSR

514A3P    ------------------------------------------------------------

514A4     --KDFPKSVNDFYERYGK-VFRLRLGSVEIVVLTGPEVIDECFNKKHREIFKERYIKFSR

515A1     --KYPHLSFKQLSDKYGK-VFSLKMGSIDTIVINDINFLQKSFRDNPTFFSQRFHLPSFY

515A2P    ------------------------------------------------------------

515B1     --GKQHLSLNELYQKYGK-VFSMKFGSYDTVILNEPDVIVEAFHLNSTSFMDRILLPSFE

516A1     ---DPHLAIQKLMFKYGN-VMTVYFANIKTVVISDPNYLKEVFVNQSHKTSDRYLMGTSR

516A2P    ------------------------------------------------------------

516B1     ---SPYKSLKSFSDKYGG-LTTIFLGSVPTVLISEPNILREIIIKNNDSIIDRYISDSGL

516B2P    ---SPFKSLKSFSAKFGG-WPPIFWGGVPPVLIGDPNFLREIFIKN--------------

508A1     --ELPHRVLTKMTKKYGH-ILRVYMADMYTVVVSDPLLIREMYVDNSDIFTDRVKKPS-V

508A2     --NLPHFDLTKMSEKYGK-IFRIYLADLYTVIVCDPIIARELFVDKFDNFIDRPKIPS-V

508A3     --GLPHRDLTKISEKYGG-IYRFWFADLYTVVLSDPILIREMFVNNGDYFLDRPKIPS-I

508A4     --SLPHRDLSKMTKDYGD-IFRVWFADLYTVVISDPVLIRKIYVENHESFRDRPKIPS-M

508C1     --TKPHIELMKLEKIYNQRILKIWLGDYYSVFLSDIDLIKDIFINKFENFSSRPKSPLTR

555A1     --NQPQNILFNYYKKYGK-IYQLQYGIVNTVVLSEFDILKEAFIENGEVFIERYNKITKK

508B1     ---EPHYTLTKMHNVYGE-IFRLHFGDVYTVVVSDPILIREMFVDNHENFKYRPLLPT-F

508B2P    -NKILYFHKLENYFKKG--IFRVWIGEVFTVIISDPLIEKEMKKTIKEKPKYIKRDIF-I

508D1     ---DTYSIMDFYHKMYGG-IYRLWFGDYFVVSLNDPEIIREIFIKNYSNFSSRPFLPTIT

508E1     --IKPHIKCHELVKQYGD-IFRVYLGDNKTIMVSDYKIIEELFIKNHNSFLERPITPS-F

554A1     ---DAHLTIPIISKKYHG-LFRMWFGGTYYVVVSDYKLIREMYIENFENFKNRIATFK-T

517A1     FKIQEHELFGGYSKKYNG-VVRAWFGERLFFFVSNYDVVKYFQKDENFHNRPSVLVPGWR

517A4     FKIQEHELIGNYSKKYNG-VVRAWIGERLFLFVSNYDVVKYFQKDENFLYRPSLLVPGWR

517A3P    FKIQEHEL-----------IVRAWIGERLFLFVSNYDV-KYFQKDENFLYKPSLLVPGWR

517A2     LNIKEHSIIERYSRKYDG-ITRIWFGDIFILYVSNYEIVKCFQKEENFFDRPSTFVPTWR

518A1     HLVFQNDSKLYKDGDNNGKIIKYWFCDQLTLAIYDTNTMKEIYLKNPESLNTRVKSPSTN

518A2P    ------------------------------------------------------------

518B1     ---QPHLVVHNDRMKY-GRFVNYWFGDYLSIAITDPILYKKIYLNFPKQINSRLKSPTVL

519A1     ---NPHRYLTNLAMKKGG-IYSVWLGDEKVFILTDPEAVRDAWVKQFRNFSDHPKTKSVR

519E1     ---QPHRSLTELAKKFGG-IFTLWMGDERSMVITDPNILRELYVKNHLNFYNRASSESIR

519B1     ---NPHRSLTELAKVYGG-VYSLHIGDSKTVVITDVSAFKDVTIKQFKNFANRPQPKSIR

519D1     ---RPNRSFLELSKRYGG-IFKIWMGEYPTVVLTDPDHVNEVWCKQFLNFTNRPHFNSLD

519C1     ---NPHRNLTKLVEKNGG-IFSLWLGDIKTVIVTDPSINKEIMVKQFTNFSDRPRLKSFE

519C2P    ---NPHRDLTKLVEKNGG-IISLCLGDIKTVIFTDPSITKEL------------------

519F1     ---RPNRSFSELSKIYGG-IYKIWLAERMLMIVTDPEIIQDIWIKQHDKFVNRPHNITSQ

519G1     ---NPNRALTKLSKKYGG-IYKIWLGESFSMVVSDPEIVNEIWVKQHDNFINRPKNITHK

519H1P    ----PHRGLKNLSDKYGG-IFRCYLGDHYSIVVSDPVIINEIYIKKFEKVCTRPNNDTFK

525A1     -DTSENTVLKWFNQLNSD-NYSVSFFGRPMIFTRDTTISKYILSSNNIDNYTKPPDSSGV

521A1     -DPYKTLAKASKKTEHG--ILKCWNGEHLMVVVDNPSIIKQMYVN-TNNFTDRPQTKVFE

522A1     ---RFHKSFDKFYDKYKD-FYFIKFGQHDCIVLNSPKLIKQVVIEQSDSVFERFHTPSIK

CYP51     ----PLQLVRNSYDRLGE-IFTLHLMGFKMTFVLGPEAQALFFRGTDEELSPKEAYRFVT

524A1     -----PFSFYEKQEKYGP-ISWTSIMNKFVLFVTDAEINRQVFKEENAKLYLSLGAKKIL

556A1     -PFQRLLNLKPKLKELGS-IYFRWFFWYPIVEIKDINAIQYVYNEKSNNYSLYWNLNKSS

 

513F1     --INNGLDIIHSNG-EYWKILKTIFQTQMTPRKIKSYQFEIQSQVDLMAEQLYKSKNNDN

513G1P    ------AGIILSNG-EVHNKIKTAVLSTITNSKIKSIKDHHFNRELLKLIEILDEIANQG

513E1     -EANGCKNLIGSND-EIHSTLKKLILTEITSNKIKKMENHIVL-ECENLCKQLDKHCQDG

513A1     -KLNNGENLVIVNG-DIHNKLKTLVLSEMTNQRIKKYETSFIDNEIKKLFKVLDEHADTG

513A2P    -CENVLLANGEMF-------------------------------KLFKELDNLAEIGEPI

513A3     -VLTGAKDLAIQNG-EIHSLLKKVVLSEMTTTKIKRMEIHIIK-ETEKILKILDKHAERG

513B1     -KLNKCSDITQENG-KNQSALKRIFLSELTVTRIKKQESHIQN-EIVKLMKVLDKHSEDG

513C1     -SINGYKGLINSNG-DYHKNLKSVILSEMTATKIKKMESHINQ-ESKRLCELLDQHAKQG

513E2P    -NLIHCSDFPFTNG-ETHSNLKKIILSEMTLTKLKKQENYIIL-ECEKLCKHLDNHCESG

513E3P    ------------------------------------------------------------

513D1     -TCNKGLNLANSNG-EYFNHLKKTLSNEITNQKMKKNE-KIIKIQVGLLSEFFNEISGGG

514A1     -FFGKDYNIISSNG-DYHYVLRGILTSEITTRKLNNGRLESNK----FILEMFSNLCKDN

514A2     -YLGKDTNILHSNG-DYHFLLKGVLSSQVTVRKLNNGRLEFNK----YILQMFNNLNNND

514A3P    ------------------------------------------------------------

514A4     -FLGKDYNIFSSNG-DYHYVLRGILTSEITTRKLNNGRLESNK----FILEMFSNLCKDN

515A1     -YMGKYQGIIFGNG-SHWRKLKDILSSSITKSKSRQMEELFYNEYFKAEEYLLKKINQDN

515A2P    ------------------------------------------------------------

515B1     VVGKNQNIGFTQTE--YWKKIRGILNISLTKSKTRLLEGLFNQEYFRFDQFIKKQLKSKS

516A1     IIGNEKDILFSNGQ--YWKNYRQILAQSFLKLRDHKGITEKISLESVKLSQAFEWYATSG

516A2P    ------------------------------------------------------------

516B1     IIGGERNLLFSKGS--FWIKYRKIFSSAMTNARKFN-IASRIEQQAISLNNYFGTYANSK

516B2P    ------------------------------------------------------------

508A1     EHGTFYHGTVTSYG-EHWKNNREIVGKAMRKTNLKHIYELLDK-QVDVLIRSMKSIETSG

508A2     KHGTFYHGTVASMG-DNWKNNKEIVGKAMRKTNLKHIYQLLDD-QVDVLIESMRTIESSG

508A3     RHATHYHGIATSSG-EYWLKIRDIINKAMRKTNLKLIYDSLDQ-QVDNLIESMNKIESDG

508A4     KYGTYYHGTAASMG-EDWVRNRGIVSSAMRKSNIKHIYEVINN-QVDVLMSTMKKYEKRS

508C1     LGTNDFRGINGSSG-ETWFKNKNIIVNAMKRANTKTIYTLLDN-QVNDLIKEISKFESQN

555A1     FKS-SEN-IVNSNG-LIWKKLQSISIQELSPNIKIKKYEPMII-NETNKLIDSFNEHIKS

508B1     KFGAGGDHGLSLSN-ERWERTRELVQNAMKRTSIKKIYDMLDS-QVYELIKSMKQYQVTG

508B2P    ---------------------------LNLKSNLINLVFNEST---INLIQSMNCSIKNN

508D1     FGSFNYRGISGSNG-DYWKRNRNLLLNAMKKSNLKQTYDNLSD-SVNSLINLMKEFQSSN

508E1     SHCSDNQNGILLSN-EKWVNNREMIQKAMKKGIVKSVYELLNK-QINDLIQSVKPFSESG

554A1     MTGDDSRGIIGCNG-DIWDSNKELIMKSYKKVLNKDMNDFILL-KSKELFNFFEKNGIKN

517A1     YASSNGLGVMSSSD-DKWKRAKSSVSQSLR---VRTTKKLMEE-KAIEFIDSLEKISNNN

517A4     YASSNGLGVMSSSD-DEWKRAKSSVSQSLR---VHTSKKLMEE-KAIEFIDSLEKISNNN

517A3P    YASSNGLGVMSSSD-DEWKRAKSSVS**LR---VHTSKKLMEE-KAIEFIDSLEKISNNN

517A2     YMSSNGGGIMSSND-EKWKRAKTTFLKSLK---IHGKKYLIEK-KSIEFVNSIEKFSNSN

518A1     VIGNRFRGIVTADE-NYWQFHRDILMKSFTGRKVKS-LSSSIEKETIDLITYMKFIEKSG

518A2P    ------------------------------------------------------------

518B1     NISERFRGIISSNE-NNWDFHHGILSKLFNGHKAKI-NNFLFEKETKFIIEYMKKISKSG

519A1     IFSGNFNDMAFAEY-SQWKINSKWVSSAFTKTKLKT-IGDLIEKESNYFIEHLKAYSNSG

519E1     IYSGNLVDISFSVG-ESWKNRRRYVSAALTKTKVLN-VITLIEEQANFLINSMQYYAKSG

519B1     VITN-FKGLAFADY-DQWQKTRKLVSSALTKTKIKT-FNNLIEKQTENLIESMNEFSNKN

519D1     QFSSGFRNLSFSDY-PLWSELRKLVSSSFTKSKVKG-ISNLLETQTNYLINTMNNYSINN

519C1     SFTGGGVNLIFIDYNEKWPVIRKIVSSSITKTKIISNYKEVIENQTKILINSMRTHSKIN

519C2P    ------------------------------------------------------------

519F1     IFSLNHKSLVFGDV-DEWNKVRPKMTCHFTKIKLNSTK-QIVNDQLKKMLKIMTTHSLDS

519G1     MFSSNYRSLNFGDN-PNWKFNRSMASSHFTKTKLLSSK-TVVEKKLNKLIETMEYHSINK

519H1P    MFSSGFKDLAFSDNYNIWSKIRTIVNSNFTKTKLTKTIYNYLEDQTNQLIENMGNYSKSG

525A1     LIRLAQNSILMSEG-DQWRYHRSIINQPFSSKNVKLMIPTIIT-TINKLINHL-IIDIHS

521A1     IISRNYKNSGFANG-EKWKHLRGLYAPSFTKIKSRPHENIILK-YVNFEIKSLKNHAITN

522A1     RYAQGKSILGCSPD--EWKKLRSFIVISFSKNKMGQQVLDKIFHTQYLKFENHIKKLIKS

CYP51     PVFGKGVVYDSETE-IMYEQLRFVKNGLVLSQLKKAVGIIQEETEKYFETKW---GDSGE

524A1     TEKAIPFIEGAP-----HRQLRKQLLPLFTIRALSSYLPIQESIVDEHIAMWIKNGKADI

556A1     NFILTGSEIKRFFR-IYYWAFNCKDSLQRIMPVIKSQVFDFIHSHKFQNSTL--STNDDV

 

513F1     --IVTNI--NENMKFMLFNIMSILIFGKQSIYCNNT-KDDDDVDKEKKHIIFSIGRFFKTSG

513G1P    --KPVQL--ISLIKQFTLNITCSLIFGFSFPI------KVENDGEASKLVNGVNNFLN----

513E1     --LPFSL--NMYFKLFSLNIILRFLFGTINN-------SYQDKSNQ--DIVDVIIEFLHYGG

513A1     --KPIIL--NNHIKMFSMNIVLCFTFGLNYSY------PYDEFEKAS-EFIKLMVEFFNIAG

513A2P    --ILNRY---IKLISSNVMLTFTYGDKLLY--------KYNEIETFE-EYLKNLSNYLKVTG

513A3     --EPFII--NNYLNMFSMNVILRFLLGIDY--------PYENVDETV-GYVKSIKSFFAVAG

513B1     --KPFLL--NNYFSMFSINIISRFLFGIDF--------PYQDFEETS-DLMVGIRDLLIASG

513C1     --TPFTM--NKYLNLFSINIILRFLFGVNY--------PYTELDDGSSSIIQVIQQFLKLVS

513E2P    --LPFKF--KFYGKLFSLNIIFRFLFGLNY--------QYDNEKIIE--IINLILELVEGAG

513E3P    --------------------------------------------------------------

513D1     ---KEPI--NNIIKMYSLNVMLSLLFNIHF--------PYNNNSYQD-ELMSTITRYFKSTG

514A1     --KE-------TLVKNTPNQIRILAVKLILNFTL----GIEENDETILIIVEKIKCIFEAAG

514A2     --EGSTM----FLANDVPSQIKKLILKVVLNFTL----GIEENDDINLSLFQNGSNIFKAAG

514A3P    --------------------------------------------------------------

514A4     --KE-------TLVKNTPNQIRILAVKLILNFTL----GIEENDETILIIVEKIKCIFEAAG

515A1     --NIDMGP---IFKRILLNILYRFLF------------GVSFEYDDNLLSKEFYSFIQSYNK

515A2P    ----DMGP---IFKRILLNILYRFLF------------GVSFEYDDNLLSK*FYSFIQSYNK

515B1     --DTMFIR--PYLKRLSFNIIYSYLF------------SETIPYEDELIPSDILDFIHASEE

516A1     --QVVNP--CSLFKMYTLNVIMQLLYSHRSSY----------DLKGQHPIIDALKMVEESLA

516A2P    --------------------------------------------------------------

516B1     --QAINP--HDYIRRYSLNGVIDYSFSDSVEY----------ESDTHHIVIRAAEIMEEILA

516B2P    --------------------------------------------------------------

508A1     --KTFDT--RYYITKFTMSAMFKFLFNHDIPE------DEDINKGDTQKLMGPMSEVFQNAG

508A2     --ETFDP--RYYLTKFTMSAMFKYIFNEDISK------DEDVHNGQLAQLMKPMQKVFKDFG

508A3     --QVFEP--RIYFKKYTMAAMYKFIFNEEIN-----------FNNEISELIGPIEQVFKDLG

508A4     --EPFEP--RYYMTKYTMAAMFKYIFNEDIGE------DEDIHTGEIQKIMGPMNQVMEDFG

508C1     --KSFNP--KYYFRKFVLSTMFKYIFNEDVPY------DENLENGKLSELTMEMENIFKTLK

555A1     --NESID--PTLNIKICFLNIIISFLFNFRY--------NDYKDEKVIQLVDYIHSIFRMGS

508B1     --NPFEI--HLYAQRFTLSIMFKYIFNEDISY------DEDITKGKIAELVQPMDQIFKSLG

508B2P    --KEFEP--KLLCSIFSFSIIFKLLFNIDLKN------ENYKEIKKIMKLVNEIN-KEKSNS

508D1     --ESFQP--DMYLRKYALTTMFKYVFNETVSF------ENKIVQGEEAELIDNINEAFNFMT

508E1     --EPLNF--RLFATRFTLSTMMTYIFNEPLSY------NENLENG--TVLYMFLENIFVLAD

554A1     --E-INN-TRFYFQSLTLTVMFKMIFNENKSF-----QLYSDSTEFKLIFKTILNLLNSLNV

517A1     --EIFYP--KGHIQGYACSMLFKYMFNQDLS----------VESGMSRTIGNAVEHVFGNLS

517A4     --EIFYP--KGHIQGYACSMLFKYMFNQDLS----------VESGMSRTIGNAVEHVFGNLS

517A3P    --EIFYP--KGHIQGYACSMLFKYMFNQDLS----------VESGLSRTIGNAVEHVFGNLS

517A2     --QVFYP--KQYSQGFTSSIFFKYMFNEDIS----------IDNKFLKEIGTAVGMVFTKNS

518A1     --QSFSP--RSNFMNFYSNIIFDYVFSRRIE-----NIYEGVNEEQGK-VLLAIRELFDYLA

518A2P    --------------------------------------------------------------

518B1     --ENFDT--RSNFLYFYSNILFDYILGKRVE-----NIYENELRKDRKKFMVSIQEVMDSVG

519A1     --QPIFP--KPYISKFGINVISGMMFSQVIS------KDESVDKGAMEKLTVPIQAVFKRLG

519E1     --EPFFP--HKYYNKYTMNIVMSIGFSKTIS------ENESVEEGPISQLIIPFYNILENLG

519B1     --ELFHP--RKYLTKYSLNIILSMLFSKEIG------KNESINKGTMERLTIPFNEAFKKVG

519D1     --KPFNP--KKYIHKLTLNVVCMIAFSKEIK------NDEDVNEGDMARLTKPKEMILKHLG

519C1     --EPFKS--KKYFGKFSISIVLGIMFKQDNDEKQININDNNIDNDPITKLTEPIQQVFLLLG

519C2P    --------------------------------------------------------------

519F1     --KPFNQ--YVYLNTYSMNIILGLMLSIELPHS-----NSNDKDGQFSKVLHSIDEIFKSIG

519G1     --LPFDS--YVGFSEYSLNIILNMLVSMDIDEC----------ENSTQNVIYSINEIFKMLS

519H1P    --EPFLST-ITIYMKISLNVICKLFFSKEILQ------NESFDNGKMRRIAVPIQIVCKELG

525A1     --YCTKLTFDIIGKLSIGYDFNSIESSDNDNDNNDDDDISKQFDFILNEMIRPIRRFSSYLP

521A1     --SIYNPFLIENINSFGTKVITEIIFGREFSE------------NEVYSLIGPMNKLFGILD

522A1     NNNIVTLEPEFKRLTISIIFNFQFGTDLEFTD------------PLIDSLLVCTEKIIASCQ

CYP51     ------IDLLYEMNKLTILTASRCLMGK----------------SINKSLGQSGQLADLYHE

524A1     --NARNN--CRDLNMAISTGVFVGNNTPES-------------------VRDDIAKNFFVMN

556A1     --TNFML--KLLSRVYLGSSDEAYHCFKAN-----------------YKKFNKSYLDFFHYL

 

513F1     SLFYSDFIPILLPFDL----INLSRNNFFKDFQVLTNFVSKNVN-QQLSKLNDNNN-NNK

513G1P    ------------------------------------------------------------

513E1     NPIMSDFIPILKPFYK---QNKFFKFYP-ILCDHLNKLIENYKNNK--QLQKQQKQQQNE

513A1     QPIISDFIPSLEPFID----TSNYLNTYKRIFNYTSDLITKFKN----ENEIHNNI-NDN

513A2P    RPILSDFIPFLKPFSK----NVNIEEWDDFFYINSNKYIEKFK----------SGK-NSK

513A3     LPILSDFIP--IPLKK----SGVFFDSYKELEIETDKLIEKFK-----KSRNEKIE-NGT

513B1     EIVLSDFLP--IPHSK----RSKLYTSYQALVVQIETLVKSHK-----------------

513C1     QPSITTYFPILSPFMND--RSKEFYDIHKLLSNHIINLIERYKDSK--QHQQQEQE-PID

513E2P    DPIISDFIP--LVKYF----ENINQNKFLKIYKKLIILIENIINNL--KLKFIENN-YDD

513E3P    ------------------------------------------------------------

513D1     LPYPSDFIPILYPFLKN--KPKEYFEDYESVKKLITRITNEYQLKH--MTEISNKS-TIE

514A1     LLIYSDYLPFLFPLDIKSMSKNDIISSYFFLKDFIGIKLDAIKIKYEKENELKNET-TDE

514A2     LFIYSDYLPFLFPLDIKSMAKSNMISSYVFVRDYLAKKLEEVKKKEYIIN-----G-DDD

514A3P    ------------------------------------------------------------

514A4     LLIYSDYLPFLFPLDIKSMSKNDIISSYFFIKDFIGIKLDAIKIKYEKENELKNET-TDE

515A1     LFEYLAKQPADFIPILKPFNNYKEIEKEYNNCLNFFQPLIDNILKNISDD------DDDG

515A2P    LFEYLAKQPADFIPILKPFNNYKEIEKEYNNCLNFFQPLIDNILKNIIDD------DDDG

515B1     LLVVLSRMPSDYIKVLRPFESHKKIKEICDRMSKFIKPRVDKKVELLDQD-------NPK

516A1     VGNVLDLFPILNIFLKKNKLKLVNNLQQVWSYSQDSIKEHREKLLIN---------PEKI

516A2P    ------------------------------------------------------------

516B1     TGNPHDYLPFLKPFYTKKRNTLAMAVGQVWDYCNDAITVHRKTLDH-----------EKP

516B2P    ------------------------------------------------------------

508A1     RGSLFDVINITQPLYLLYLEMFDQSFKDIMKYHREKYNEHLKTFDPD-----------VE

508A2     TGSLFDVLEITRPLYFLYLEWFTSHYYQVINFGKMKIYKHLETYKPD-----------VQ

508A3     SGSLFDVLLISRPLYYQWIEHTDKNYPKILNFLKKKYHQHLKTYNPE-----------IQ

508A4     TGSLFDVLEISQTFYLKWLELTEKNFPLLLKFFNGRYEQHLETIKPE-----------SP

508C1     VGKLANSIEILETPYYYYLQKTDKVFKNIKKLIIEKYKNHNLSINPE-----------KP

555A1     -----HPIPQDYIPILNKFYINKTTKIHQKIFENIYEYIENQVQKRLEILNKNN-NNNIN

508B1     SGKLGDFISIAQPFYYQWLKFSDKQFNGPFSTVKKFIYKRYLEHINT-------IDHDNP

508B2P    SDLNSITNFIENQFYYHISNIDQRLVDFFFFYNLIINNIIYNLYFNL----------ISL

508D1     LGNAGDFFKILQPLYYQYLLYRGGCFNRIRTLIRNRYIEHRKTIDIE-----------NP

508E1     VGHIGDYISFLKPIYSLFLKLTDSNVPLARDYVYKKFYEHLKTIDNEKE---------EN

554A1     YNVIYDFLGIFQPILLKFTKILDKNSFLSKIATEKFNSRIKEIDFTSDDFKAN-----DL

517A1     KLTAFDCFEIFSPLYDWFFTRRLKGCDIVRQIISSQNENHLKSIDPS-----------KP

517A4     KLTAFDCFEIFSPLYDWFFTRRLKGCDIVRQIISSQNENHLKSIDPS-----------KP

517A3P    KLTAFDCFEIFSPLYDWFFTRRLKGCDIVRQIISSQNENHFKSIDPS-----------KP

517A2     HLTVFDCFGILSPFYDLFFKFRLRPIEILKKTIDKQLTNHLNSMDSKMGDH-------QS

518A1     DTLIVNYLIFTKPFYFLYLKMFGHPADSLKKILTKYYLEHFESIDLN-----------NA

518A2P    ------------PFYFIYSKIFGHPSDPLKNIINKYY*EHCETIYID-----------NP

518B1     LIKFLNYLILSYPFLSIYLRYFTYTTFNLKKILKQYYDEHLETIDLN-----------KP

519A1     ADNLDDFISILQPVFYFQNEKFKRQVQEIYDYLEGIYNQHDTNLDT------------EN

519E1     SGNLGDYVWYTQPFFYFKNKKLEQDTKKVYTFLEEIYNEHIKNLDE------------SN

519B1     --KVDDFLWFLSPFFYFSNKQYKKYIFDIYYFMEEIYDQHLLDLDY------------NE

519D1     SSNFCDFVPLVRPLFYLKNKRFDQTLKQVIEYIKEIYDDHLLNLDLN-----------SS

519C1     TGNISDFIKILRPFFKNEYKKLNNSASKVFKFMEEIYDQHLLKFDK------------SN

519C2P    ------------------------------------------------------------

519F1     TNGPEDIFPTLLPFFKNRISTFTNHLNVIKDFIRSIYKQQIKTFDIN-----------IE

519G1     TNSPQYSFPYLKFFFKKDLNNFKFHLDKIKSFIHSIYLKQLESYDP------------SN

519H1P    AGNFGDFVGILSPLLYFTKKKYQKNSSTSTDFIGEINDEHLKNLDHD------------S

525A1     -LYNDIKLFKFLNELESIIKGAINSRSLITDNNNNKTYKKNFLLDNL-----------LD

521A1     TPFPSESISFLKPFYRRSYKECDKQCEELFKLVEKVYDDHLLNLDKD-----------NP

522A1     KASDLMPIFEIFTSYKDIDGVVKEMYALVKPFLEKYLKQHDRNNPKC-------------

CYP51     LEEGLNPISFFFPNLPLPSFKKRDAARAKVAAIFHSIIQERRRSTDD-----------SV

524A1     EGFLCLPIDLPGTTLRKAINARVRLVEIFTDIIAKSRKRMGDGEKPQ-------------

556A1     ---FPTLLKIPSKFLRKYIKNKNKRALYQVLAMKAYYGVVKQSSDDH------------I

 

513F1     EKEGEERKSIVEAYLENYLNGEIKFESVLSSCTNLLLAGTDSSANT-LSFLLVSLINNP

513G1P    -----------------------------------------------------------

513E1     DDDDDDDGTIIGKLLKEYHNGKISWTSVVSTCVDVFLAGVDSTSNS-TIFTLIALVNNS

513A1     NKSLADKP-ILSKLLQSFENGEISWDSVVSTCIDLQTAGADTSANT-ILYCLLELINNP

513A2P    QSKTENKP-IISKLLSLYENGEISWASVIGSCIDMQASSTDT-----IMFCLIELTNLK

513A3     YNEEEDES-ILSKLLKEYEHGNITWECVSHTCIDIISAGTDTSANT-LVMALIELINNQ

513B1     -YKEDDEC-MLSKLMIEHDKGNIPWDAVISNCNTIITAGSDSTSST-ALFFLIEMMNNP

513C1     GATEPTVT-ILDKLLIEVENNRITQNALISICIDVLIAGTDTVGQT-LSFAIVALVNNA

513E2P    DNDENNIT-IFLKLFKEFKNGKITWDNLVGTCVDLTVGGTDTVSDS-LNFSLIALINNP

513E3P    -----------------------------------------------------------

513D1     EIENYQPTNILESLLKQYRLNKIPYDGVIGCLMDLILAGSDTTGNT-CLFSLVALVNNS

514A1     TSSKLNNIPIIENYYKNYLDGSIHYDSILFSISDIIFAAVDSTSNG-FSLLIGQLINKP

514A2     GGVDTSQTPLIESYYKLYLQGLIGYDSILLSIVDIIIASVDTTSNS-ISFIIARLTNHQ

514A3P    ----LSGIPFVEDCYESYLDGSVRYDSFLFSVSDVVFAAVDSASNG-FSLLIGQLFNRP

514A4     TSSKLNNIPIIENYYKNYLDGSIHYDSILFSISDIIFAAVDSTSNG-FSLLIGQLINKP

515A1     NEPKCFLEYFISEIRKDTS-NLIKITDLPYICFDIIVAGIVTTSTT-MDWMLLYLTNYP

515A2P    IEPKCFLEYFISEIRKDTS-NLIKITDL------------VTTSTT-MDWLLLYLTNYP

515B1     CFIDYLILQI----RSDPSQ-TIKIDAIQYIVLDLLVGGTDSTSSA-LEWMILFLSNHE

516A1     DDLLDLFINEIKLSKNSEFFD---DEGLYRVCSDLLLSGTETSSST-MSWLLLFLINNP

516A2P    -----------------------------------------------------------

516B1     RDLLDLILMEIEKSEEKQFYD---DDSLSKCLTDLIVAGHETVAIT-LGWMILFLSNHQ

516B2P    -----------------------------------------------------------

508A1     RDLLDILIKEYGTDNDDKI-----LSILAT-INDFFLAGVDTSSTA-LESMVLMLTNYP

508A2     RDLMDLLIKEYGTETDDQI-----LSISAT-VSDFFLAGVDTSATS-LELIVMMLINYP

508A3     RDLLDLLIKEYYSGSDDDI-----LTIIAT-INDLFLAGTDTSSAS-LEYMVMMLVNYP

508A4     RDLLDILINEYGTNTHDDY-----LNIAST-VLDFFFAGTDTSSTT-LEYLFLMMANYP

508C1     RDLLDILINEYGT-TDDDV-----LNITQV-TLDMFMAGTDTTANT-LEWIIIKLCNSP

555A1     ECFVDLLLLKFKSNLLTW------NEVIKT-TTDLMIAGSDTNSLF-TIHLIIALTNRE

508B1     RDLMDLLINEFSNDKNLI------PTILQT-SLDMFLAGNDTTAAS-IIWFVLRMQEHP

508B2P    KDFMDIIIYKENSFETKEK---IKKQVVYK-CTDYILNKSESISKV-IENFFVLIAQDQ

508D1     RDLLDLLIIEYGDHSDEN------MISIVQVCFDVILAGVDTLASS-LEWFLVMLCNNQ

508E1     YDLLHTFIKEVGIKDKES------VKSIVSNSLDLLVAGTDTAAKG-IEWIILRIANNQ

554A1     LDSLIMTINEDENGLNEKQ-----IENIKSICIDFLMAGTDTTGST-IEWIILKLVNNP

517A1     RDLMDDLLIEYG-LNEITK---EDTMQINQICFDIFGPAVGTVTIT-MNWVILQLCNRP

517A4     RDLMDDLLIEYG-LNEITK---EDTMQINQICFDIFGPAVGTVTIT-MNWVILQLCNRP

517A3P    RDLMDDLLIEYG-LNEITK---EDTMKINQICFDIFGPAIGTVTIT-MNWVILQLCNRP

517A2     RDIMDDLLIEYGSLNEISN---QDRIQINQICFDVMSTDIGTVATT-IDWVLLQLCNRQ

518A1     RDVLDSLIIEYRKVGGK-----EEQSSIIPMVNELILAGTETNSST-AEWFILTMVNNL

518A2P    RDVLDSIISEYRKVNGK-----EECS---------ILAAVENNSAT-MKWFTL-----

518B1     RDVLDNLIMEYKNQNAI-----ECDKSFVAIAIELLAAGTDTNSST-SEWFLTYLVNNP

519A1     PKDLMDLLIISTEGK--------ERDMIIHIGMDCLLAGSDSTSAT-CEWFCLFMINNP

519E1     PRDLMDQLIISTGGK--------EKDMVIHVSTDFLLAGSDTNAST-LEWFCIFLANNP

519B1     PKDLLDQLIIASQGR--------EKETVILVGMDFLLAGSDTQKAT-QEWFCLYLINNP

519D1     PKDIMDLLIMSTNDS--------KEDIIIHTCIDLLIAGSDTVGVT-FRVFRFIYPNNP

519C1     PRDLMDYFIEYEFTNSPNTTLEEKKISIIKGCMSFVFAGDDTVAAT-LEWVCLYLINNP

519C2P    -----------------------------------------------------------

519F1     PRNIMDCLISEYYEDDDQEDEVAKQELIIQLCIDMLVAATDTSAST-LEWFMLFMINNP

519G1     PRNILDSFISDLQSNDI--------DILLQICIDIVVAGTDTVANL-LQWFVLFCINYP

519H1P    PKDLMDMLIIDST------------KGKDEDKEPIVHIGYDFLMVD--QIRHL-VLWN-

525A1     -----------DNVK--------EKDII-GNINTFLLAGHETSANL-LTFIFYLLSTHN

521A1     KDVMDVMIVETDFKE---------KDHVICICCDLLMGTKDTFNTI-VLWFFVLMINYQ

522A1     --ALDHMINCILDQDEPKL---ITYEHLPHFLMDMFIGGTESTART-MDWFTLMMTNRK

CYP51     DDVLYTLMNSKYKDGSVLE-----DEQIVGLMIGLLFAGQHTSSIT-LTYTIFYLLNNL

524A1     --SLIDLWVEHFLNCPKEERDELSNDTIIFTLLSFMFASQDALTSS-LVWTVQLMAEHP

556A1     EESMINIIAETSYNDKEGL-----SLEEIKMPSYLL------NASS--IKGPMIMVENL

 

513F1     EIQEKVYNEII--------------------TNLKNDEISINDRFKCPYTCAVIKETHRL

513G1P    ------------------------------------------------------------

513E1     NCQEKLFNEIKNNLKKSDDGHDE------------IVIRHSLYRSSIPYLSLVMKEVYRL

513A1     NIQSKVYDDIKQAIIQSKENENQNDNENQEQTEEIITLSFNKYRTLAPYLSMVVKETFRK

513A2P    NIQNKVYNEIKQEIKKQNINNNNNEDE--------VLIQYNKYRNSLPYFSMVIKETFRK

513A3     EIQSKAFSSIRSSCLNDSNDDDDDDE---------IVITHSKYRSLLPYISMIIKETFRK

513B1     TIQTKVYNDIVVSFEQNQQADDYMNES-------MVILKYSKYRSLIPYLSLALKENYRK

513C1     EIQEKLSRNIIDSMEKGDN-----------------HYSYSKYRNGIPYLALVVKEVFRM

513E2P    NCQEKLYNEIKNELLKNNNNNNIDDL---------IILKHSLYRLSIPYLSMVMKETYRN

513E3P    ----------------------------------------------ITYPSMIMKEVYRL

513D1     NIQEKLFNEISNAFNDDDGDELNGANDISN---SLLKLSYFSDRIKTPYLVAFIKEVKRY

514A1     EIQDKIYEEIMRNDENNNTNN-----------------ISFADHTKYPYIISVMNESYRY

514A2     EIQSKIYEEIMSNDINNNSNN-----------------ISFSDHSKYPYIISIMNETYRY

514A3P    GIQDGIYEGIMRNDEVSNADD-----------------MSFADRAECPCVFSVMDESYRF

514A4     EIQDKIYEEIMRNDENNNTNN-----------------ISFADHTKYPYIISVMNESYRY

515A1     NIQEKLFFEINTPN-----------------------HPLHKDKLQFPYLNSIIKETLRI

515A2P    NIQEKLFFEINTPN-----------------------HPLHKDKLQFPYLNSFIKETLRI

515B1     SIQEKLYNEICKNTNTNTTATTTENDNESY-------FPKLIEKNNYPLFNACVKETLRR

516A1     NFQDKVRTELLEATGGKK-------------------TIGLTEKSKTPFFNACIKEALRI

516A2P    ------------------------------------------------------------

516B1     DVQQKVYDELINVVGKGN-------------------LPALVHRKDTSYLNACIQETMRI

516B2P    ------------------------------------------------------------

508A1     EIQEKAFDEIKTVVNG-------------------RSKVNLSDRQSTPYLVAVIKETLRY

508A2     EYQEKAYNEIKSALSSNGGGGGGGL--------TQRNKVLLSDRQSTPFVVSLFKETLRY

508A3     EIQEKVYDEIKLTVNG-------------------RNKVLLSDRQFTPYTVSFIKETLRY

508A4     EIQDKVHQEVKSYLKQIG-----------------KDKVELNDRQSLPYVVAVIKETLRF

508C1     IHQEIAYNELKKVVSSKVIIDDS-----------IKREITLSDRPNTPYIQAIIKETMRM

555A1     NIQNKVFNEILNFYILN-----------------ENNKITFSNKSKTPYYNSVLKEVERR

508B1     EIQLKAYNEIKDAVGD-------------------RDRVLLSDRPKTPYLNAIIKEILRL

508B2P    DYQYLAFNELKSVINTKLLYNGVG-----------ENIIKLSDKSYTPITNSICKEVLRL

508D1     QIQDTVYNELKETVVG--------------------PVVTLNDRPSTPYTMACIKETIRL

508E1     DVQELIFKELKSIVDSCG---------------RVEDRIYLSDRSSTPYLNATIKESMRI

554A1     EFQELIFQELKKLNKSEI---------------------PAKNKINTPFLNSFIKETNRL

517A1     ELQEIAYQEIKKAVKDDE-------------------YVNLNHKQNAPYIVAFIKETMRL

517A4     ELQEIAYQEIKKAVKDDE-------------------YVNLNHKQNAPYIVAFIKETMRL

517A3P    EPQEIAYLEIKKAVKDDE-------------------YVNFNHKQNAPYIVAFIKETMRL

517A2     DLQEIICNEIQDTIKIKRNNVINDGGGGAD---TDNLFINLCDKQSIPYLIAFIKETMRV

518A1     DYQDKIYNELKSTLET------------------TTAMIKLSNRNQTPLFNAALKEVLRL

518A2P    -------------------------------------LINLSHRPLTPLFNASLKEVLRL

518B1     IYQDKIYDELIGALKINKPLKG------------SDVLINLSHRPLTPLFNATLKEVLRL

519A1     DVQKKAYQELINALKD-------------E---DNKKFIPISKKDNCPYMLSIFKEVLRL

519E1     EIQKKAYEELISVVGK------------------DCKAVTTKYRDDCPYLVGAIKETLRM

519B1     DVQKKAYQELISVVG------------------KDCKFVTSNHIENCPYFISIIKEVFRI

519D1     IIQEKCFNELFNAFSNSNNTDNNNNNST-I---TAAIGFGDEYSSKTPFLNACIKEVLRI

519C1     AIQEKCYNELISVLGDNNNE-------------SKIKFISLKERDNCQYLINVIKEVLRI

519C2P    ------------------------------------------------------------

519F1     NLQEDLYEEVVNVVG------------------KDCPYVTFDDVPKLALIKACYFEILRI

519G1     EIQEKLYNEIIEVVG------------------KDCKVLKYEHISKMPYLYGCFRESLRI

519H1P    DCQEKAYNEIVSVMG------------------EDCNKISYADRPKLPYLVACINECLRM

525A1     NVQNDLYNHLIENQKKKIN-------------KDNKFTEEDEDYQSIEFLDWVIYETLRL

521A1     DVQLKGYQEIIKVLECTG-----------------RDHVTIEDIDKLPYIDGIIKEISRI

522A1     EMQDRIRTELLDVGIRLP---------------------VLVDKQKYPLLNASIKEIHRL

CYP51     EYFDETQKDINDIVQKENQ-----------------GEINFDGLKRMNRLETVIREVLRL

524A1     DILAKVRAEQASLRPNNE-------------------KLDLDTMRQATYTRMVVSEILRF

556A1     MFQLIEKSEIESKIRKEIKLVFE-------KNGKDVNSFDFDDIMEMKYLEATLDEINRL

 

513F1     YSIAPLSEPHYC------SNDVEIKG--FKIAKGTQIIQNIYSSSRSEQYWDK-PLSFIP

513G1P    ------------------------------------------------------------

513E1     YSVILIGLPHIT------SEDVEIEG--YKIAKGTQIIQNVFSTHLCEKTFPM-SKSFIP

513A1     YPSGTIGLPHVT------SEDVELNG--YKICAGTQIIQNIWATHRNEKQFSE-PDSFIP

513A2P    HP----VTAHET------SNDVEFRG--YKISKGTQIIKNIWATHRNEKIFQS-PNSFIP

513A3     HPIALLGLPHVT------TEDVEIDG--YKIEAGTYIIQNIFSSHRSDKIFQS-PNEFIP

513B1     HPAAPFGAPHET------TQETVIEG--YTIAKGTMIFQNIYATQRSDTFYSQ-PDEFIP

513C1     YPAGILGLPHMT------SEDCEIQG--HKIAKGTQIIQNIYSTHRSESFWPN-PNNFIP

513E2P    FPVALLGL----------------------------------------------------

513E3P    YPVGVLGLPVLI------DNDIEIDG--FKIKKGTQIIKNFYQSHRHEDFFKL-PNHFIP

513D1     YPCAPLSVPHLL------TEDCEIQG--YKIAKGTQVIQNIYSTHLSQSFCSN-PLEFSP

514A1     NSSVPITEPNKT------TEDVEVNG--YKIAKGTMIIKNLRGTHLSKEFWGEDALEFKP

514A2     YASVPLPEPNMT------TEDIEVDG--YKIAKGTQIYKNIRGTLISKEFWGEDALEFKP

514A3P    YSSVPITEPNVA------TGDVEVNG--YRIAEGAMII-NLRGAHFSRGFWG--------

514A4     NSSVPITEPNKT------TEDVEVNG--YKIAKGTMIIKNLRGTHLSKEFWGEDALEFKP

515A1     SPPAPFALPHIC------TDDIVIDD--IFIPKNTQVIPNIYGCNRSNIESSE-SNVFNP

515A2P    SPPAPFALPHIC------TDDIVIDD--IFIPKNTQVIPNLYGCNRSNIESSE-PNIFNP

515B1     SPPVPLGLPHLC------SEDTEIGG--YLIPKGTQIISNIYSASNCDKVFTD-PLEFNP

516A1     RPVGALSLPRIA------SEDVTCGP--YTIEKGSQIIMNVYGLAMDPTVWED-PETFNP

516A2P    ---------KMA------REDGTWGP--XXXRGGQIKKERVRGLGRGPTVWGG-PETFLP

516B1     RTAAPLALPRIA------SEDIKVGG--YTIPKGTQVMMSVYGMASDERYWKD-PHIFNP

516B2P    ------------------------------------------------------------

508A1     KPMSPFGLPRSS------SKDCMIG--GHFIPKNAQILINYQALGMNEEYYEN-PEQFDP

508A2     KPISPFGLPRST------TSDIILNN-GQFIPKNAQILINYHALSRNEEYFEN-PNQFDP

508A3     KPPSSVGVPRTT------SQDIIIG--DKFIPKDAQIFINYYGLSRNQDYFEN-PEQFEP

508A4     KPVTPFGVPRSC------VNEITIDE-KYFIPKGAQVIINYPSIFENEKYFKN-ANQFDP

508C1     HPVVVFGLPRYC------ENDIFIGDENYFIPKGCKVFINFHSIGYNEKYFKD-PYKFEP

555A1     FTVSPLSQPHRT------NKDIILNG--YFIPSGSQIIQNVYSCHLNDKDWEN-PFQFNP

508B1     NPVGPFGLPHRS------SNDIVIGNGKYFIPKDSQILVNYRGLGFNEKYFEN-PSQFDP

508B2P    NPVDQLSSPITC------KKDSLVNG--YFIPKDSQIIINHKSMNLNEKYFND-PFNFNP

508D1     KAPAPFGLPHTT------DQDIIVKG--HFIPKDSMVLINFYSLGRNPKDFPD-PLKFDP

508E1     TPITPYGIPRVV------GKDLIIKG--HFIPKGSHVVINYRALNHDESIYKN-PNQFNP

554A1     YPIAPLSLPKSN-LNFGIINEMIIGDNKYYIPANTNILMDVKGFSLDENNYKD-PNEFKP

517A1     CSNG-FGLPRTA------KNDQICGD--FFIPKDAIIFINYLEISQNEEIFKN-AKEFNP

517A4     CSNG-FGLPRTA------KNDQICGD--FFIPKDAIIFINYLEISQNEEIFKN-AKEFNP

517A3P    CSNG--------------------------------------------------------

517A2     FSNG-WSLPKTS------KHDQICAN--YFIPKGSILFINYFSIHLNEEFFKN-PREFNP

518A1     YPPVPFGVPRQVN-----QSFEINGGS-LKIPKGTQIIQSLYSIFRDENYWDS-PDQFKP

518A2P    YPPVSIGVSRLVI-----EEFTIDNGK-YTFLKGAQIIQSLYSIFRDEKYWSS-PNEFIP

518B1     IPATP--FSVPRM----SNEGFEVDG--IKIPKGTYLFPSMYSIFRDEKYWGENANKFYP

519A1     RPVGVLGIPRVA------LEETTIMG--YTIPKGSQIFQNVYGMS--HLFVSD-PYKFKP

519E1     RTPAPLSLIRVS------EEDFMTSGG-IFIPKGTQIVPNLYGIG--QNFVDD-PSSYKP

519B1     RSPGPLGLPRIS------IDDTYLSNG-MFIPKGTQILLNIFGMG--NLLVSE-PDQFKP

519D1     KPVTSLGLPRIA------NDDTFVNG--YRIPKGTPIIENIYGLSNSDQLIDD-PTTFNP

519C1     RTPLPLSVPRIA------TQNCEING--FFIEKGTQILSNAFGMS--HLYVDE-PNVFNP

519C2P    ------------------------------------------------------------

519F1     RPVTSLSLPRVS------MEDTTTLN-DIFIPKDTIIIQNIFGMGNSEKFVSN-PTVFNP

519G1     RPVTPLSLPRVA------KCDTYIKD-DIFIPKGATIIQNIFGMGNDEKYISE-PNKFKP

519H1P    RTEDPLGIPRGA------VEDIEING--YFMPKGAKVHHYLYAFGMNETVFEN-VNKFQP

525A1     FPPAPMIGRTSK------NDDILKSG-NISIPSETLILISVYAIHRDPKLWKD-PNIFNP

521A1     HPAGPLSVPRTA------INDIMING--YFIPKGCHVFQNTYGAVYNYMKESDEPCKMKP

522A1     RPIQPIIASRVVNDPIVLKHECSAKGESYTIPVGTLIIPNAHSFNFDPQYHKD-PLTFNP

CYP51     HPPLIFLMRKVMT-------PMEYKG--KTIPAGHILAVSPQVGMRLPTVYKN-PDSFEP

524A1     RPPAVMVPHENI-------EDIVIGDN-VHVPKGTMILPSIWSAHFQEGGYSD-PYKFDP

556A1     YPPFPKLMPRQT-------KESDRILG-YHIPKGTMISCPVADILRDPSNFQD-PLTFKP

 

513F1     ERFIDNANIKEK--------------------NKNIVSFGLGLRGCIGKSFAEYMIFLTV

513G1P    ------------------------------------------------------------

513E1     ERFIETGSNNMFGGG-----------------QTNLVHFGTGVRDCVGKSLADCEIFTVL

513A1     ERFISQQQSA----------------------NSNLIHFGCGVRDCIGKSLADSEIFTML

513A2P    ERFLEELP------------------------NSNLVHFGVGVRDCMGKSLAESQIFTIL

513A3     ERFFESSQ------------------------NQGLIHFGLGVRDCVGKSLAECEIFTLI

513B1     ERWNGDEN------------------------SQTLISFGTGIRDCIGKSLAYNEIFTII

513C1     ERHIQNDVS-------------------------KSVHFAVGTRNCMGMSLSEAEVHTAM

513E2P    ------------------------------------------------------------

513E3P    ERNIESGNKFIYGCG-----------------DTNMVQFGLGNRDCIGKSLATSEIFTLL

513D1     ERFLDSTNE------------------------PKIITFGIGQRKCPGENIFEIEIYIFL

514A1     ERFKNQPLY-----------------------QKGLFHFGAGPRGCPGGRFTESFTFTFL

514A2     ERFKTQTLN-----------------------QKGLLHFGAGPRGCPGARFTECFFFTLM

514A3P    ------------------------------------------------------------

514A4     ERFKNQPLN-----------------------QKGLFHFGAGARACPGGRFTESFTFTFL

515A1     DHFLS-KDE----------------------LNIGQCAFSFGSRQCPGANVADSIMFLVS

515A2P    DRFLS-KDE----------------------SNIGQCAFSSGLRQCPGANVADSIMFLVS

515B1     LRFIENSP-------------------------PQTVTFSTGPRVCPGKNLSEDELFSFG

516A1     YRWLSSDIS---------------------QSTYSFIPFGCGSRVCVGSSLARDEIFLGI

516A2P    XXXXXXXXX---------------------XXXXSVIPCGWGSRGWGGSSLAREEILVGM

516B1     ERWLSSNHSTENGGGGGG-------VVGNSSQSEVFIPFGVGPRMCVGMGVAKDELYYCA

516B2P    ------------------------------------------------------------

508A1     SRFLKV------------------------ESNVAFLPFSIGIRSCVGQSFAQDELYICI

508A2     TRFLNS------------------------DSNPAFMPFSIGPRNCVGSNFAQDEIYIAL

508A3     SRFMNP------------------------DTNIAFLPFSIGTRNCVGQNFALDEMFLAF

508A4     SRFLQTTTTNTASNEE-----------SSFNSNLAFIPFSIGPRNCVGMQFAQDELFLAF

508C1     NRFLENSN----------------------NSMDSFFPFGLGNRVCLGRQLANDQLYLVI

555A1     DRFLNNNQ-----------------------LEKKLITFGMGPRNCLGFQFALMSIWIVN

508B1     SRFLNKNN-------------------------DAYMPFGVGDRKCVGLQLAGDEQYLSF

508B2P    KRFLNYNN--------------------------QSINF--------------DEIYIAI

508D1     NRFIGSTP-------------------------DSFMPFGTGPRNCIGQALGMDQIYLLL

508E1     NRFLDN-------------------------NIESFIPFSIGNRNCVGQQIANHELFLFV

554A1     DRFLNSK-------------------------VSDTLNFGIGPRNCIGQTIAMNQIHIFL

517A1     TRYLDES------------------------LPVPNIHFGVGQRACPGRFVAIDKMFLGI

517A4     TRYLDES------------------------LPVPNKHFGVGQRACPGRFVAIDKMFLGI

517A3P    ------------------------------------------------------------

517A2     ARYLDDS------------------------IPIPDLHFGIGQRGCPGRFVAMDQVFLCI

518A1     ERFLDQDS-----------------------HSNNYFPYGIGVRNCIGMGFSQDELYISL

518A2P    ERFIYQNN-----------------------*SNNWFPYSIGVRNCVGMGFSQDELYLLL

518B1     ERFLTDS------------------------HSNNYFPYGVGKRMCLGSNFSQHELYICL

519A1     ERWIEYKKQKDLLKEKEM-KPNSKTNSIFDDLDKVSIPYSVGNRKCPGASLSELALFSLC

519E1     ERWVEYYKNKTPTREMEATKSNITTEILPNDLDKVVLPFSIGPRNCPGNIISEINLFLAC

519B1     ERWINYKNQQQQKQQQQQ-SSESSNLEFFDDLEKVSNPFSLGPRNCVGMAIAKSSIYSVC

519D1     YRWLEYQKLKSFQNDLKQ-NNSNNKHKYYNDLDKISIPFSTGRRGCVGVQLGEAELYIVC

519C1     DRWINYYNQKQQQQQQQQQPQPIQNNNYFNDLDRVCLPFSTGPRNCVGISIAELNLFSVC

519C2P    ------------------------------------------------------------

519F1     SRWLEYKKMKDLNQFGNR-TLNGTTSKYYNDLERVSIPFGVGKRRCMAPSMADHNVLIAM

519G1     ERWVEYIKNKKVNKNGN----ENSVNKYFNDLDKISIPFGVGKRQCLSPAMAEQESLLSI

519H1P    DRWLTNDQVHLK------------------QMLNHLVPFSVGPRSCFGKNLSELEVFVVC

525A1     YRWKNIENIN---------------------NRSDFIPFSSGGRVCVGQKFSIVEARIII

521A1     ERWIENEKLRKDGKLDPTN-----------DLALISLPFSSGIRNCPGVGFAEYELFLLF

522A1     NRYIGDNPE------------------------ILHMTFDIGIRTCPFMSFAIDELFIIF

CYP51     KRFDVEDKTP-----------------------FSFIAFGGGKHGCPGENFGILQIKTIW

524A1     QRFDSVRKED-------------------VTCAKNSLVFGAGPHFCIGKELAKNQIEVFL

556A1     ERQLIFSNPKFASPSITSI-QEINGLSKRNQRIIKNLPWGIGSKKCLGKELAKLIVKTII

 

513F1     VRLIKNYKFSNPSP-NQPLKEIGEYGLVMNCANYNAKIEKRK-------

513G1P    -------------------------------------------------

513E1     ATLINRYQFINPT--LEPLNDIGSFGIAYQPP-INNFIIKKRL------

513A1     ASLINRYEFTNPNP-STPLNEIGKFGITYSCP-ENKIIIKKRF------

513A2P    ASFINRYEFLNPNP-SIPLNDVGKFGLAFSCP-QNKIIIKKRK------

513A3     ATLLNRYQFINPNN-SKKLNDIGTFGLAQVCP-DTNIILKKRI------

513B1     ASVLNRYEFINPNP-SIPFDDNGIPGLTTQCK-NTVVQIKKR-------

513C1     AELFGNFKFTNPS--NIPLNDQGTFSVALNCP-DFFVKIERRN------

513E2P    -------------------------------------------------

513E3P    ATLINRYEF*NPKP-SIPLNDKGKLS-----------------------

513D1     VYLIKKFKFSHPIDDNLQLNDRGQFGLSLQCP-QLNIKVESR-------

514A1     VIMLKNFKIVNPTD--IPIDVEGEVGLAMQCK-PFDALFIKRN------

514A2     VLLFKNYKLQNPND--NPIDDRGDVGLSMQCK-PYDALFIKRN------

514A3P    -------------------------------------------------

514A4     VIMLKNFKIVNPTD--IPIDVEGEVGLAMQCK-PFDALFIKRN------

515A1     TKLYKTFKFERTTT--QLNDENGHFTRSLSPF-EFKSKLIIRK------

515A2P    TKLYKTFKFERTTT--QLNDENGYLTKTLCPL-EFKSKLIIRK------

515B1     TKLFKTFKFSRPNK-NQLYDEVAILGITLEPK-PFITKVSLRS------

516A1     GNILLNYIFESQNG--KPINEKGHFGIALQTV-DYNVKLTKI-------

516A2P    GNV*LNYIWESQKG--KPIKEKGHLGSALQTG-DYNVKVTKI-------

516B1     SQMFMNFKWSPVND--KPIDDEGVARIALEYK-EYQVVLERRK------

516B2P    -------------------------------------------------

508A1     SNILLNFKLKSIDG--KKIDETEEYGLTLKTKNRFNVTLEKRII-----

508A2     SNMILNFKFKSIDG--KPVDETQTYGLTLKPN-PFKVILEKRK------

508A3     SNIILNFKFSSIDG--KQIDETELYGVTLRCKNKFNVSIKKRI------

508A4     ANIVLNFTIKSVDG--KKIDETISYGVTLKPKTRFKVLLEKRLI-----

508C1     ANLILKYKLKTIDE--NKINEDGIFGLTVSPN-KYKINLESR-------

555A1     LILFKSIKFSSNKL---IEEEIREGGTTLSPF-PFKINLIKR-------

508B1     SNILLNFNLKNI-G--TPVSDYEEFGLTLKPN-KFKVLLESRK------

508B2P    SNILLNFKIT-------AVKNHYNFNVFDDNL-QSSVLIEKR-------

508D1     SNIFLNFKITSENG-KKLDDTDYVSGLNLKPA-KYKVCLEKR-------

508E1     SNFILNYKITPITN--EPIDTTENFGINIRPN-SFKINVYKRN------

554A1     SNLILNYRMFSIDC--LPLPENLILSVSVRPT-EYSLKLIKRV------

517A1     SNLLLKYKLKSQNG--EKIDDTIHFSVSLKAK-DYGIKLEKRI------

517A4     SNLLLKYKLKTQNG--EKIDDSIQFSVSLKAK-DYGIKLEKRI------

517A3P    -------------------------------------------------

517A2     ANTLLKYKIKSIDG--KKIDDTIQFSVYLKPK-DFGILLEKRNKLFVND

518A1     SNLVLNFKLLPLIE-NSKICDKPIFGFSFKPN-EFKINLEKRNN-----

518A2P    TNLVLNFHILPPFE-NTKIDGTPIFGFSFKPK-LR--------------

518B1     TNIVLNFKIKSIDG--KPLNEIPNYGITFRPN-IFEVKLENR-------

519A1     SNILLNFELKSIDG--KPIDDTEVYGLTIHTK-VHPISLTLRP------

519E1     SNILLNFEFSNG-G--KKIDETEVFGITIHPK-DFSIQLKKRE------

519B1     SNILLNFELSSINN--QIIDDNEVFGVSINPK-EFSIKLTKR-------

519D1     ANLVYNFKIESWDG--KKINELEDFGIIIHPS-SHNLKITKRNNK----

519C1     ANIILNFQIKSIDG--MQLKDIEVSGISIHPI-PFSIKLISRN------

519C2P    -------------------------------------------------

519F1     ANIVLNFTMKSSDP--KQMPLSEEEQYAITIKPKYPFKVLFEKRS----

519G1     ATVVLNYKLKS-NG--QKKLNEKEVYSITIKPQPFKLFLEKRV------

519H1P    SNILLNFELSSYNG-----KPVDDFEIFGIHPPEFPVKLIKRK------

525A1     SKLILNFELSFNNL--KSKPFKIYQRATLPPKYPVFLNFKKRENN----

521A1     SNIILNFHLSSPNN--LKLNESGHFGLTMKPF-PFLVDLN---------

522A1     SRLFQSFEFQPIDN--TPISEEAFTINSIRPK-QWSCQVIERDHK----

CYP51     TVLSTKYNLEVGPV-----PPTDFTSLVAGPKGPCMVKYSKKQK-----

524A1     TKLAMSTEWTHNKT---PGGDEIIFGPTIFPKDGCNITIKARN------

556A1     VILYSQYTFDKHLD----ENDEELCDTNNQPKIQITFNPEIKPPLLLK-