Dog P450s




Modified Jan. 8, 2010

See the newest collection of dog P450 sequences
Dog FASTA file

The data below is old but it has some annotation and some accession numbers. Last modified Oct. 6, 2003 A 1.5X coverage of the dog genome (78% sequence coverage) has been assembled against the mouse and human genome. GENOMICS: A Dog's Breakfast? Stephen J. O'Brien and William J. Murphy Science 301, Issue of 26 Sep 2003, pp. 1854-1855. The Dog Genome: Survey Sequencing and Comparative Analysis Ewen F. Kirkness,1 Vineet Bafna, Aaron L. Halpern, Samuel Levy, Karin Remington, Douglas B. Rusch, Arthur L. Delcher,1 Mihai Pop,1 Wei Wang,1 Claire M. Fraser,1 J. Craig Venter Science 301, Issue of 26 Sep 2003, pp. 1898-1903. The AACN01 contigs have been deposited in the wgs section of Genbank (about 1.1 million sequences with accessions AACN010000001 and higher. The Canis familiaris whole genome shotgun (WGS) project has the project accession AACN000000000. This version of the project (01) has the accession number AACN010000000, and consists of sequences AACN010000001-AACN011089636. There are about 853,000 singleton reads CE000001 to CE853796 placed in the GSS section. Some additional dog sequences are in the nr and HTGS sections of Genbank. There are 27,010 ESTs from dog. Please note the NIH is doing a 6X sequence of a boxer named Tasha. That will be in addition to the 1.5X coverage of Craig Venter's poodle Shadow. NHGRI news release on chimp, honeybee and dog genomes As of Sept 30, 2003 the new genome shotgun sequences in WGS are Blast searchable at Genbank. The 853796 accessions in GSS are now blast searchable (Oct. 2, 2003).

Below are dog P450s found in Genbank by keyword search or by blast searches of the 1.9 million shotgun reads from the genome project. This is nearly finished, but some genes in subfamilies cannot be assembled without long range assembly data. This affects the 2C and 4A subfamilies especially. There is HTGS data for the 3A subfamily, so these genes could be assembled. Right now there is no way to distinguish between 11B1 and 11B2, since these are nearly identical in human and mouse. Current results suggest that dog may only have 54 P450 genes. There seem to be very few expanded subfamilies. Note on privately held dog sequences. Incyte Corporation has a large collection of ESTs from dog in its ZooSeq database. The Sept. 2003 datasheet lists 554,766 Incyte ESTs These fall into 50,793 gene bins with more than one EST and an additional 75,147 gene bins with only one EST. The distinction is made because singletons are not as reliable to be real genes. This number is twice the number of predicted human genes, so these bins may represent some large genes split into separate bins, or alternative splice variants of single genes. Alpha list of 275 WGS(247), GSS(20), HTGS(1), dbEST(6), and dbSTS(1) accessions 10/6/03 (in progress) AACN010001547 11A1 exons 7,8,9 77% to 11A1 AACN010002469 CYP3A new exon 1 AACN010003495 4B pseudogene exon 2 72 % to 4B1 may be a pseudogene AACN010004324 1A2 AACN010004769 4A exon 1 73% to 4A22 AACN010005020 2C not 2C21 or 2C41, exons 1,2 47% to 2C9 55% to 2C44 AACN010009337 4X1 exon 9 75% to 4X1 AACN010011564 5A1 exon 1 AACN010011846 CYP3A new exons 7,8,9 87% to 3a12 86% to 3a26 AACN010013846 2F exons 1, 2 92% to 2F1 AACN010015736 24A1 AACN010017119 39A1 exon 2 AACN010018024 2A exons 5, 6, 7 85% to 2A13 AACN010022403 4X1 exons 11, 12 82% to 4X1 AACN010022579 8A1 exon 4 AACN010024457 4A exons 10, 11 AACN010025457 4A exon 1 75% to 4A22 AACN010025457 4B pseudogene exon 1, 2 pseudogene fragment like 4B1 AACN010027010 8A1 Exons 8,9 AACN010027413 39A1 exon 8 AACN010030717 2AC1 exons 6,7,8 AACN010047271 7B1 exon 2 AACN010049021 4X1 Exons 5, 6 68% to 4X1 AACN010050790 3A26 exon 10, 11 AACN010053444 3A12 exon 11 AACN010053733 11A1 exon 2 86% to 11A1 AACN010055666 CYP3A new exon 1 AACN010060907 2U1 exons 4,5 93% to 2U1 AACN010061832 CYP3A new exons 5,6 86% to 3A26, 85% to 3A12 AACN010063288 4X1 exon 2 73% to 4X1 AACN010064928 4X1 Exons 7, 8 69% to 4X1 AACN010067442 1A1 AACN010076390 39A1 exons 3, 4 part of exon 5, runs off end AACN010078512 46A1 exon 9 AACN010078951 8A1 exon 6 partial runs off end 88% to 8A1 AACN010081846 2C exon 6 73% to 2C18 AACN010085847 2B11 exons 2,3 79% to 2B6 AACN010089968 1A1 AACN010092086 27B1 AACN010094237 2J exon 4 80% to 2J2 AACN010095657 4V exon 1 CYP4V AACN010097049 2G1 exons 8,9 partial, only 2 diffs with 2G1P runs off both ends AACN010102290 4V exon 8 87% to 4V2 AACN010103563 1A2 AACN010114089 2B exons 7,8 80% to 2B6 AACN010121970 46A1 exon 3 AACN010124695 4F22 ortholog exons 6,7,8 91% to 4F22 AACN010126951 46A1 part of exon 5, exon 6 AACN010128919 24A1 AACN010130281 4B1 exon 2, 3 AACN010134828 4V exon 7 67% to 4V2 AACN010137865 51A1 exon 2 AACN010152085 20A1 exon 9 AACN010159249 5A1 exon 9 AACN010161991 2B pseudogene 62% to 2B6 AACN010168096 8A1 exon 2 AACN010169255 7A1 exons 2,3 AACN010174454 21A exon 5 81% to 21A2 AACN010174600 3A26 exon 9 AACN010186119 CYP3A new exon 2 87% to CYP3A12 and 3A26 AACN010188536 4A exon 12 AACN010189575 24A1 AACN010191886 3A26 exons 5, 6 AACN010192013 4A EXON 12 AACN010195735 exons 8,9 75% to Cyp2ab1 mouse AACN010195862 CYP3A new exon 5 89% to 3a26 87% to 3a12 AACN010197444 11A1 exon 6 81% to 11A1 AACN010197522 51A1 exons 6, 7 AACN010201865 51A1 exon 4 AACN010204642 26B1 exon 6 AACN010208625 2G exons 6, 7 87% to 2G2P AACN010210799 5A1 exon 2 AACN010211165 4X1 exon 1 89% to 4X1 AACN010213676 CYP3A new exon 12 AACN010220406 CYP3A new exon 12 AACN010226278 20A1 exon 11 AACN010230693 5A1 exon 4 AACN010231889 2C21 exon 1 67% to 2C19 AACN010232554 CYP3A new exon 3 AACN010239142 51A1 exon 5 AACN010239150 27C1 exon 7 AACN010241790 4F22 ortholog Exons 11, 12 93% to 4F22 AACN010243007 2C exon 2 75% to 2C9 AACN010243485 CYP3A new exon 13 61% to 3A4 last exon 77% to 3a12 72% to 3a26 AACN010244558 24A1 AACN010247777 2AC1 exon 9 AACN010249334 2C exon 3 70% to 2C9 AACN010250179 20A1 exon 8 AACN010252256 3A26 exon 4 AACN010252699 2A exons 1, 2 81% to 2A13 AACN010254090 39A1 exon 10 AACN010254948 4A exon 12 AACN010260817 5A1 exon 3 AACN010266987 3A12 exon 12 AACN010269590 20A1 exon 1 AACN010273103 2G1 exon 3 84% to 2G1 mouse AACN010277385 20A1 exon 4 AACN010277497 4B pseudogene exon 2 77% to 4B1 pseudogene fragment AACN010282153 2S1 exons 4,5 AACN010287562 3A26 exon 8 AACN010289085 4V exon 11 CYP4V AACN010289085 4V exons 9, 10 85% to 4V2 AACN010292487 2J exon 6 90% to 2J2 AACN010295104 20A1 exon 10 AACN010304672 4F2,3,8 ortholog exons 5, 6 75% to 4F11 (not the 4F22 ortholog) AACN010305079 5A1 exon 5 AACN010314449 2W1 exon 2 85% to 2W1 AACN010319098 4A exon 1 67% to 4A11 AACN010319956 26A1 AACN010323944 4A exon 4 90% to 4A11 AACN010330145 CYP3A new exon 2 93% to 3A12 and 3a26 AACN010331905 26A1 AACN010333576 26C1 AACN010339993 2R1 C-term 95% to 2R1 AACN010344851 2A exon 2 95% to 2A13 AACN010347037 4V exon 12 84% to 4V2 AACN010353628 4A exon 6,7,8,9 83% to 4A11 AACN010353889 17A1 AACN010355109 4A exons 2,3 AACN010361281 5A1 exon 8 AACN010373352 4A exon 12 AACN010374456 CYP3A new exon 8 86% to 3a12 and 3a26 AACN010387783 26B1 exon 3 partial runs off end AACN010393088 27C1 exon 4 AACN010393942 19A1 AACN010397206 4F22 ortholog exon 4 95% to 4F22 AACN010397206 4F22 ortholog Exons 3,4,5 87% to 4F22 AACN010399536 3A26 exon 7 AACN010405105 4A exon 5 76% to 4A11 AACN010407010 19A1 AACN010411687 2J exon 7 81% to 2J2 AACN010415404 4F22 ortholog Exon 2 91% to 4F22 AACN010416264 39A1 exon 6 AACN010420800 11B C-term AACN010438403 27A1 AACN010451212 2E1 exon 1 64% to 2e1 AACN010455688 2D exons 1,2 76% to 2D AACN010455794 4F2,3,8 ortholog exon 1 partial (not the 4F22 ortholog) AACN010459300 2U1 exon 2 AACN010471757 2S1 exons 8,9 83% to 2S1 AACN010473034 11B mid to I-helix AACN010473930 11A1 exon 1 74% to 11A1 AACN010475988 24A1 AACN010480974 4B pseudogene exon 2 77% to 4B1 partial may be a pseudogene AACN010485402 19A1 AACN010487676 46A1 exons 12,13 AACN010494378 4B1 exon 4 83% to 4B1 AACN010505917 27C1 exon 9 AACN010517076 1A2 AACN010517201 2W1 exon 1 77% to 2W1 AACN010525666 51A1 exon 3 AACN010530471 4F2,3,8 ortholog Exons 3,4 78% to 4F2 (not the 4F22 ortholog) AACN010532410 2J exon 5 77% to 2J2 AACN010533299 20A1 exon 3 AACN010540042 7B1 exon 3 partial AACN010540669 4A exons 10,11 AACN010542530 19A1 AACN010551605 2R1 mid region AACN010553294 4A exon 9 AACN010556807 4F2,3,8 ortholog Exons 7,8 91% to 4F2 (not the 4F22 ortholog) AACN010562079 46A1 exons 10,11 AACN010562135 4A exons 6,7 77% to 4A11 AACN010571055 2E1 exon 6 AACN010571884 4A exon 12 AACN010574925 2C? exon 5 56% to 2C19 AACN010593213 4V exon 3 CYP4V AACN010596498 4A exons 6,7,8 80% to 4A11 AACN010604838 2C? exon 5 58% to 2C44 AACN010608941 2E1 exon 3 76% to 2E1 AACN010621190 4B1 exons 5, 6, 7 86% to 4B1 AACN010628019 5A1 exon 12 AACN010629095 39A1 exon 9 AACN010634041 4B1 exon 8 92% to 4B1 AACN010637808 4F22 ortholog exon 10 AACN010641940 2A exon 5 83% to 2A13 runs off end probable 2A6 ortholog AACN010644044 4F2,3,8 ortholog Exons 5,6 89% to 4F3 (not the 4F22 ortholog) AACN010654075 CYP3A new exon 3 AACN010655492 20A1 exon 6 AACN010667637 27C1 exon 3 AACN010681921 2G1 exon 1 86% to 2G1 mouse AACN010686725 2C exon 3 76% to 2C19 AACN010702410 2B11 exon 9 86% to 2B6 AACN010705299 1B1 AACN010708847 4V exon 5 CYP4V AACN010716778 2W1 exons 6,7,8 87% to 2W1 AACN010724666 27C1 exon 5 duplicate AACN010725049 39A1 exon 1 AACN010746253 4F2,3,8 ortholog Exons 9, 10 86% to 4F3 (not the 4F22 ortholog) AACN010751339 3A26 exon 12 partial AACN010759102 20A1 exon 13 AACN010760976 2C exon 7 74% to 2C19 AACN010774717 26B1 exon 4 runs off end AACN010792582 5A1 exon 11 AACN010807017 2F exon 8 93% to 2F1 AACN010822105 26B1 exon 2 AACN010825222 2S1 exon 6 80% to 2S1 AACN010825609 26C1 exon 2 part is 100% identical to human AACN010830399 26A1 AACN010840222 4F2,3,8 ortholog Exon 8 90% to 4F8 (not the 4F22 ortholog) AACN010845392 27A1 AACN010849796 8B1 AACN010852794 19A1 AACN010864510 4A exon 5 76% to 4A11 AACN010867864 27C1 exon 10 AACN010869183 11B exon 1 AACN010874668 51A1P AACN010876926 11A1 exon 5 AACN010877904 1B1 C-term AACN010891180 26C1 AACN010901744 11B exon 3 runs off end AACN010901969 4A exons 10, 11 AACN010902297 3A12 exon 13 AACN010902592 2F exon 3 90% to 2F1 AACN010903862 7B1 exon 5 AACN010905536 27B1 AACN010912139 46A1 exon 4 AACN010925329 4F2,3,8 ortholog exon 8 90% to 4F8 (not the 4F22 ortholog) AACN010929795 19A1 AACN010931414 39A1 exon 7 with frameshifts AACN010935863 4F22 ortholog Exon 1 82% to 4F22 AACN010936951 27A1 AACN010944904 17A1 AACN010949834 2G1 exons 4, 5 89% to 2G2P AACN010965485 4A exon 3 82% to 4A11 AACN010968095 27B1 AACN010968133 exon 9 97% to 2F1 runs off end AACN010981930 11A1 exon 1 71% to 11A short dulicate AACN010983002 26B1 exon 5 partial runs off end AACN010993726 5A1 exon 7 AACN010994363 2AC1 exon 1 69% to 2AC1P runs off end AACN010999381 2S1 exon 2 83% to 2S1 AACN011007565 2E1 exon 9 83% to 2E1 AACN011010355 2AC1 exon 3 82% to 2AC1P AACN011037110 8A1 exon 10 partial runs off end AACN011038787 2AC1 exon 2 86% to 2AC1P AACN011043035 46A1 exons 7, 8 AACN011045402 4B1 exons 10, 11 partial runs off end AACN011049752 2S1 exon 7 86% to 2S1 AACN011051454 27C1 exon 5 AACN011052580 CYP3A new exon 11 85% to 3A12 81% to 3A26 AACN011054638 2F exon 5 71% to 2F1P AACN011062291 2D exons 8,9 83% to 2d6 AACN011063676 46A1 exon 1 AACN011064056 3A26 exon 13 3A26 AACN011071482 51A1 exon 1, partial runs off end AACN011088664 2D15 exon 6 one aa diff to 2D15 AACN011088907 11B J-helix to K-helix AC131027.14 CYP3A contig in HTGS section (3 genes) AJ402312 2E1 EST AJ402323 2E1 EST AJ402324 2E1 exons 1-4 EST 68% to 2E1 AJ411545.1 4F22 ortholog exon 9 from dbSTS BM536554 17A1 N-term EST BM537848 17A1 N-term EST BM539980 17A1 EST CE047857 4A exons 8,9 88% to 4A11 CE061184 2R1 exon 1 CE064315 4A Exon 12 partial 75% to 4A11 CE121306 11A1 exon 3 CE132262 26B1 exon 1 CE135061 11B C-helix CE152057 4A exon 8 partial , exon 9 93% to 4A11 CE167218 2F exon 7 partial 92% to 2F1 runs off end CE199997 2T exon 2 90% to 2T3P CE214916 4F2,3,8 ortholog Exon 8 partial 91% to 4F12 (not the 4F22 ortholog) CE234625 4A Exons 10,11 81% to 4A11 CE327517 4A Exon 12 74% to 4A11 CE328062 26A1 CE343572 4B1 exon 1 78% to 4B1 runs off end CE357229 26C1 exon 1 partial CE387110 4F2,3,8 ortholog exon 1 extreme N-term (not the 4F22 ortholog) CE447392 27A1 CE502020 2A exon 4 partial runs off end 93% to 2A13 probable 2A13 ortholog CE624939 2A exon 4 90% to 2A13 runs off end probable 2A13 ortholog >AACN010067442.1 Canis familiaris ctg19866850684014, whole genome shotgun sequence Length = 3045 79% to 1A1 human N-term AACN010089968.1 Canis familiaris ctg19866851895459, whole genome shotgun sequence Length = 2768 84% to 1A1 C-term full length combined seq = 81% to 1A1 1868 MFRLSIPISASELLLASTVFCLVLWVVKAWQPRLPKGLKSPPGPWGWPLLGNVLTLGKSPHLALS 2062 2063 RLSQRYGDVLQIRIGSTPVLVLSGLDTIRQALVRQGDDFKGRPDLYSFSLVTDGQSLTFS 2242 2243 PDSGPVWAARRRLAQNALKSFSIASDPASSCSCYLEEHVSKEAEVLLSRLQEQMAEVGRF 2422 2423 DPYRYIVVSVANVICAMCFSKRYDHDDQELLSLVNLSNEFGEGVASANPLDFFPILRYLP 2602 2603 NPALDFFKDLNKRFYSFMQKMVKEHYKTFEK 2695 133 GQIRDVTDSLIEHCQDKRLDENANIQLSDEKIVNVVLDLFGA 258 347 GFDTVTTAISWSLLYLVTNPNVQKKIQKEL 436 529 DTVIGRARQPRLSDRPQLPYMEAFILETFRHASFVPFTIPH STTRDTSLSGFYIPKGRCVFVNQWQINHDQ 885 1038 KLWGNPSEFQPERFLTLDGTINKALSEKVILFGLGKRKCIGETIARLEVFLFLAILLQQ 1217 1218 VEFSVPEGTKVDMTPIYGLTMKHARCEHFQVRVRTEGAERSAA* 1349 >AF203025 CYP1A1 exon 4 same as AH009261 GFDTVTTAISWSLLYLVTNPNVQKKIQKEL >AF203026 CYP1A1 exon 6 STTRDTSLSGFYIPKGRCV >L77459 STS for CYP1A1 L77458 = opposite primer in non-coding region NQWQIN >CYP1A2 AACN010103563.1 Canis familiaris ctg19866850724666, whole genome shotgun sequence Length = 2627 90% to 1A2 AACN010517076.1 Canis familiaris ctg19866850724664, whole genome shotgun sequence Length = 1130 82% to 1A2 human N-term AACN010004324.1 Canis familiaris ctg19866850196532, whole genome shotgun sequence Length = 5709 86% to 1A2 C-term combined sequence for 1A2 362 MALSQMATELLLASTIFCLILWVVKVWQPRLPKGLKSPPGPWGWPLLGNVLTLGKSPHLALS 177 176 RLSQRYGDVLQIRIGSTPVLVLSSLDTIRQALVRQGDDFKGRPDLYSFSLVT DGQSLTFSPDSGPVWAARRRLAQNALNTFSIASDPASSCSCYLEE 771 770 HVSKEAEALLSRLQEQMAEVGRFDPYNQVLMSVANVIGAMCFGHHFSQRSEEMLPLLMSS 591 590 SDFVETVSSGNPLDFFPILQYMPNSALQRFKNFNQTFVQSLQKIVQEHYQDFDE 429 3 exons missing 628 STTKNTTLKGFYIPKECCVFINQWQVNHDQ 717 1789 QVWGDPFAFRPERFLTADGTAINKTLSEKVMLFGMGKRRCIGEVLAKWEIFLFLAILLQ 1968 1969 RLEFSVPAGVRVDLTPIYGLTMKHTRCEHVQARPRFSIK* 2088 >CYP1A2 dog PIR A60463 (16 amino acids) Ohta, K., Motoya, M., Komori, M., Miura, T., Kitada, M. and Kamataki, T. A novel form of cytochrome P-450 in beagle dogs. P-450-D3 is a low spin form of cytochrome P-450 but with catalytic and structural properties similar to P-450d. Biochem. Pharmacol. 38, 91-96 (1989) >AACN010705299.1 Canis familiaris ctg19866851123367, whole genome shotgun sequence Length = 932 85% to 1B1 aa 82-344 AACN010877904.1 Canis familiaris ctg19866851497256, whole genome shotgun sequence Length = 766 85% to 1B1 human aa 386-end Combined CYP1B1 seq Missing N-term 81 aa 2 GDVFQIRLGSCRVVVLNGERAIRQALVQQGAAFADRPRFASFRVVSGGRSLAFGQYSPRWKVQR 194 195 RAAHSTMRAFSTRQPRSRRVLEGHVLAETRELVALLARGSAGGAFLDPRPLTVVAVA 365 366 NVMSAVCFGCRYSHDDAEFRELLSHNEEFGRTVGAGSLVDVLPWLQRFPNPVRTAFREFE 545 546 QLNRNFSNFVLRKFLRHRESLQPGAAPRDMMDAFILSAGTEAAEGSGDGGARLDMEYVPA 725 726 TVTDIFGASQDTLSIALQWLLI 791 (seq gap 54 aa) 765 IPHATTTSACVLGYHIPKDTVVFVNQWSVNHDPVKWPNPEDFDPVRFLDKDGFIDKDLAS 586 585 SVMIFSVGKRRCIGEELSKMQLFLFISILAHQCNFKANPDEPSKMDFNYGLTIK 424 There seem to be two CYP2A genes in dog. One is a 2A13 ortholog and the other is more like 2A6 and 2A7 >CYP2A13 ortholog AACN010344851.1 Canis familiaris ctg19866851067108, whole genome shotgun sequence Length = 1390 exons 2,3 94% to 2A13 1261 ISERYGPVFTIHLGPRPVVVLCGHEAVKEALVDQAEEFSGRGEQATFDWLFKGY 1100 291 GVAFSNGERAKQLRRFSITTLRDFGVGKRGIEERIQEEAGFLIEALXXXX 154 CE502020 tigr-gss-dog-17000327340429 Dog Library Canis familiaris genomic. Length = 555 exon 4 partial runs off end 93% to 2A13 553 XXXXXXXXXXXRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQ 425 CE624939 tigr-gss-dog-17000328384715 Dog Library Canis familiaris genomic. Length = 539 exon 4 90% to 2A13 runs off end 3 XXXXXXXXXXXXXXXXXXXXXXFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQ 98 >CYP2A AACN010018024.1 Canis familiaris ctg19866850786388, whole genome shotgun sequence Length = 4311 exons 5, 6, 7, 8, 9 89% to 2A13 669 LYEMFYSVMKHLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRMQE 848 1339 EQNNPNTEFHLKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDVE 1479 1882 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDIIPLSLARRVIKDTKFREFLLPK 2070 ALEVFPMLGSVLRDAKFFSNPQDF 2764 2766 HPQHFLDEKGQFKKSDAFVPFSI 2834 3382 GKRYCFGEGLARMELFLFLTTILQNFHFKSPQLPQDIDVSPKHVGFATIPQNYTMSFQPR 3561 missing exon 1 1261 ISERYGPVFTIHLGPRPVVVLCGHEAVKEALVDQAEEFSGRGEQATFDWLFKGY 1100 291 GVAFSNGERAKQLRRFSITTLRDFGVGKRGIEERIQEEAGFLIEALXXXX 154 553 XXXXXXXXXXXRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSMGQ 425 669 LYEMFYSVMKHLPGPQQQAFKELQGLEDFITKKVEQNQRTLDPNSPRDFIDSFLIRMQE 848 1339 EQNNPNTEFHLKNLVLTTLNLFFAGTETVSTTLRYGFLLLMKHPDVE 1479 1882 AKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDIIPLSLARRVIKDTKFREFLLPK 2070 ALEVFPMLGSVLRDAKFFSNPQDF 2764 (frameshift) 2766 HPQHFLDEKGQFKKSDAFVPFSI 2834 3382 GKRYCFGEGLARMELFLFLTTILQNFHFKSPQLPQDIDVSPKHVGFATIPQNYTMSFQPR 3561 >CYP2A6,7 ortholog AACN010252699.1 Canis familiaris ctg19866850356168, whole genome shotgun sequence Length = 1701 exon 1, 2 83% to 2A13 AACN010641940.1 Canis familiaris ctg19866851583170, whole genome shotgun sequence Length = 997 exon 5 83% to 2A13 runs off end 738 MVASGILLVALLTCLTVMVLMSVRRQWKLLEKLPPGPTPLPFIGNYLQLNIQQMSDSFMK 917 1197 ISKRYGPVFTIHLGPRRVVVLCGYEAVKEALVDQAEEFSGRGAQATFDTLFKGY 1358 missing exons 3-4 851 LCEMFHSVIKYLPGPQQQAIKELQGLEDFITKKVEQNQRTXDPNSPRDFXXXXXXXXXX 996 missing exons 6-9 >CYP2B11 AACN010085847.1 Canis familiaris ctg19866850955811, whole genome shotgun sequence Length = 2814 exons 2, 3 81% to 2B6 AACN010114089.1 Canis familiaris ctg19866851882663, whole genome shotgun sequence Length = 2526 exons 7, 8 CYP2B 1927 LQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGY 1766 1619 GVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTE 1470 1325 RIYKEIDQVIGPHRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPK 1510 1678 GTEVFPILHSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSI 1818 2B11 AACN010085847.1 Canis familiaris ctg19866850955811, whole genome shotgun sequence Length = 2814 exons 2,3 79% to 2B6 1930 QLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIAVVEPVFQGY 1766 1619 GVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKTEGE 1464 2B11 AACN010702410.1 Canis familiaris ctg19866851325389, whole genome shotgun sequence Length = 935 exon 9 86% to 2B6 226 GKRICLGEGIARMELFLFFTTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSR 405 new 2B PSEUDOGENE AACN010161991.1 Canis familiaris ctg19866850769592, whole genome shotgun sequence Length = 2145 62% to 2B6 possible 2B pseudogene 2011 LRKKYGDVFTVYLGPRPVIILCGYRAVREALVDQ 1907 (large coding region deletion) 789 KVEVEIDRIIGPH 751 (frameshift with small deletion) 752 TLEDLAKLPYTHAVIQEIQRFSDIIPLGIPHCVTKDTHFHSYHLPK 615 >CYP2B11 dog GenEMBL M92447 M33575 Graves,P.E., Elhag,G.A., Ciaccio,P.J., Bourque,D.P. and Halpert,J.R. cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl Arch. Biochem. Biophys. 281 (1), 106-115 (1990) MELSVLLLLALLTGLLLLMARGHPKAYGHLPPGPRPLPILGNFL QMDRKGLLKSFLRLQEKYGDVFTVYLGPRRTVMLCGIDAIREALVDNAEAFSGRGKIA VVEPVFQGYGVVFANGERWKTLRRFSLATMRDFGMGKRSVEERIQEEAQCLVEELRKT EGVLQDPTFFFHSMTANIICSIVFGKRFGYKDPEFLRLMNLFYVSFALISSFSSQMFE LFHSFLKYFPGTHRQVYNNLQEIKAFIARMVEKHRETLDPSAPRDFIDAYLIRMDKEK AEPSSEFHHRNLIDTALSLFFAGTETTSTTLRYGFLLMLKYPHIAERIYKEIDQVIGP HRLPSLDDRAKMPYTDAVIHEIQRFGDLLPIGVPHMVTKDICFRGYIIPKGTEVFPIL HSALNDPHYFEKPDVFNPDHFLDANGALKKNEAFIPFSIGKRICLGEGIARMELFLFF TTILQNFSVASPMAPEDIDLTPQEIGVGKLPPVYQISFLSRGGC >CYP2C21 AF049909 MDLFIVLVICLSCLISFFLWNQNRAKGKLPPGPTPLPIIGNILQINT KNVSKSLSKLAENYGPVFTVYFGMKPTVVLYGYEAVKEALIDRSEEFSGRGHFPLLDW TIQGLGIVFSNGEKWKQTRRFSLTVLRNMGMGKKTVEDRIQEEALYLVEALKKTNASP CDPTFLLGCAPCNVICSIIFQNRFEYDDKDFLTLLEYFHENLLISSTSWIQLYNAFPL LIHYLPGSHHVLFKNIANQFKFISEKIKEHEESLNFSNPRDFIDYFLIKIEKEKHNKQ SEFTMDNLIITIWDVFSAGTETTSTTLRYGLLVLLKHPDVTAKVQEEIHRVVGRHRSP CMQDRSCMPYTDAVVHEIQRYIDLVPNNLPHSVTQDIKFREYLIPKGTTILTSLTSVL HDEKGFPNPDQFDPGHFLDENGSFKKSDYFMAFSAGKRVCVGEGLARMELFLLLTNIL QHFTLKPLVDPKDIDTTPIANGLGATPPSYKLCFVPV >CYP2C21 AACN010574925.1 Canis familiaris ctg19866850505796, whole genome shotgun sequence Length = 1067 exon 5 56% to 2C19 708 LYNAFPLLIHYLPGSHHVLFKNIANQFKFISEKIKEHEESLNFSNPRDFIDYFLIKIEKVKCDPLS 905 >CYP2C21 dog PIR A60465 (33 amino acids) Komori, M., Shimada, H., Miura, T. and Kamataki, T. Interspecies homology of liver microsomal cytochrome P-450. A form of dog cytochrome P-450 (P-450-D1) crossreactive with antibodies to rat P-450-male. Biochem. Pharmacol. 38, 235-240 (1989) Note: probable N-terminal of 2C21 xxlfivlvix lsxlisfflw nqnxakgxlp pgp >CYP2C21 AACN010231889.1 Canis familiaris ctg19866850874016, whole genome shotgun sequence Length = 1799 exon 1 1385 MDLFIVLVICLSCLISFFLWNQNRAK 1462 >CYP2C21 AACN010243007.1 Canis familiaris ctg19866851499128, whole genome shotgun sequence Length = 1748 exon 2 75% to 2C9 788 LAENYGPVFTVYFGMKPTVVLYGYEAVKEALIDRSEEFSGRGHFPLLDWTIQGL >CYP2C21 AACN010249334.1 Canis familiaris ctg19866850218528, whole genome shotgun sequence Length = 1717 exon 3 70% to 2C9 760 GIVFSNGEKWKQTRRFSLTVLRNMGMGKKTVEDRIQEEALYLVEALKK 903 >CYP2C21 AACN010081846.1 Canis familiaris ctg19866851883697, whole genome shotgun sequence Length = 2860 exon 6 73% to 2C18 503 EKHNKQSEFTMDNLIITIWDVFSAGTETTSTTLRYGLLVLLKHPDV 640 >CYP2C21 AACN010231889.1 Canis familiaris ctg19866850874016, whole genome shotgun sequence Length = 1799 exon 1 67% to 2C19 1391 LFIVLVICLSCLISFFLWNQNRAKGKLPPGPTPLPIIGNILQINTKNVSKSLSK 1552 >CYP2C not 21 or 41 AACN010005020.1 Canis familiaris ctg19866850176241, whole genome shotgun sequence Length = 5562 exons 1,2 47% to 2C9 55% to 2C44 3894 MALLGLPTFLVACVAFLLFIFVWRRGGTRGRLLPPGPPPLPIIGNILQVNLWDLPNSLSR 3715 1966 LAEQYGSVYSLRLGAHPVVVLHGYQALKEALCGQAVNFEGRGKFPIMDNALRGYG 1802 >CYP2C CE146812 tigr-gss-dog-17000371294512 Dog Library Canis familiaris genomic. Length = 612 exon 7 78% to 2C9 1 diff to 2C21 probably 2C21 477 AKVQEEIHRVVGRHRSPCMQDRSCMPYTDAGVHEIQRYIDLVP 605 >CYP2C new not 2C21 or 41 AACN010686725.1 Canis familiaris ctg19866851474338, whole genome shotgun sequence Length = 951 exon 3 76% to 2C19 703 GIVFSHGERWKQMRRFTLMTLRNFGMGKRSIEDRIQEEAQHLMQAL 840 >CYP2C? new not 2C21 or 41 may not be in 2C subfamily AACN010604838.1 Canis familiaris ctg19866851656290, whole genome shotgun sequence Length = 1036 exon 5 58% to 2C44 50% to 2C21 and 2C41 972 LYNLWPSFIHYLPGRHQKFFKNIQNIKNFILEKVAQHQETLKPEQPRDYTDCFLDRMEE 796 >CYP2C new not 2C21 or 41 AACN010760976.1 Canis familiaris ctg19866850697245, whole genome shotgun sequence Length = 876 exon 7 74% to 2C19 72% to 2C21 261 KIHEEIDRVVGRDRVPCMNDRAQMPYTDAVVHEVQRYINLIPSNLPHAVTQDTKFRQFYIPK 446 >CYP2C41 dog GenEMBL AF016248 Blaisdell,J., Goldstein,J.A. and Bai,S.A. Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression Drug Metab. Dispos. 26 (3), 278-283 (1998) MDPVVVLVLCLSCCLLLSLWKQSSRKGKLPPGPTPLPFIGNILQ LDKDINKSLSNLSKAYGPVFTLYFGMKPTVVLHGYDAVKETLIDLGEEFSARGRFPIA EKVSGGHGIIFTSGNRWKEMRRFALTTLRNLGMGKSDLESRVQEEACYLVEELRKTNA LPCDPTFVLGCASCNVICSIIFQNRFDYTDQTLIGFLEKLNENFRILSSPWIQAYNSF PALLHYLPGSHNTIFKNFAFIKSYILEKIKEHQESFDVNNPRDFIDYFLIKMEQEKHN QPLEFTFENLKTIATDLFGAGTETTSTTLRYGLLLLLKHPEVTVKVQEEIDRVIGRHQ SPHMQDRSRMPYTNAVLHEIQRYIDLVPNSLPHAVTCDVKFRNYVIPKGTTILISLSS VLSDEKEFPRPEIFDPAHFLDDSGNFKKSDYFMAFSAGKRICVGEGLARMELFLFLTT ILQKFTLKPLVDPKDIDTTPLASGFGHVPPTYQLCFIPV >CYP2C41 dog no accession number Stephen R. Bai and Joyce A. Goldstein clone M2c9h submitted to Nomenclature Committee >CYP2D15 AACN010455688.1 Canis familiaris ctg19866851122450, whole genome shotgun sequence Length = 1204 exons 1,2 76% to 2D AACN011088664.1 Canis familiaris ctg19866851280594, whole genome shotgun sequence Length = 253 exon 6 74% to 2D6 one aa diff to 2D15 AACN011062291.1 Canis familiaris ctg19866851626334, whole genome shotgun sequence Length = 545 exons 8,9 83% to 2d6 959 GPLAVAVAIFLLLVDLMHRRRRWATRYPPGPTPVPMVGNLLQMDFQEPICYFSQVRKVG 147 FGNVFSLELAWTPVVVLNGLEAVREALVHRSEDTADRPPMPIY 19 101 AKGNPKTSFNEENLCMVTSDLFVAGMVSTSITLTWALLLMILHPDVQ 241 460 GTTLITNLSSVLKDEKVWKKPFRFYPEHFLDAQGHFVKHEAFMPFSA 320 225 GRRVCLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSDHGVFTFLKVPAPFQLCVEPR 49 >CYP2D15 dog GenEMBL D17397 Sakamoto,K., Kirita,S., Baba,T., Nakamura,Y., Yamazoe,Y., Kato,R., Takanaka,A. and Matsubara,T. A new cytochrome P450 form belonging to the CYP2D in dog liver microsomes: purification, cDNA cloning, and enzyme characterization Arch. Biochem. Biophys. 319 (2), 372-382 (1995) MGLLTGDTLGPLAVAVAIFLLLVDLMHRRRRWATRYPPGPTPVP MVGNLLQMDFQEPICYFSQLQGRFGNVFSLELAWTPVVVLNGLEAVREALVHRSEDTA DRPPMPIYDHLGLGPESQGLFLARYGRAWREQRRFSLSTLRNFGLGRKSLEQWVTEEA SCLCAAFAEQAGRPFGPGALLNKAVSNVISSLTYGRRFEYDDPRLLQLLELTQQALKQ DSGFLREALNSIPVLLHIPGLASKVFSAQKAIITLTNEMIQEHRKTRDPTQPPRHLID AFVDEIEKAKGNPKTSFNEENLCMVTSDLFIAGMVSTSITLTWALLLMILHPDVQRRV QQEIDEVIGREQLPEMGDQTRMPFTVAVIHEVQRFGDIVPLGVPHMTSRDTEVQGFLI PKGTTLITNLSSVLKDEKVWKKPFRFYPEHFLDAQGHFVKHEAFMPFSAGRRVCLGEP LARMELFLFFTCLLQRFSFSVPAGQPRPSDHGVFTFLKVPAPFQLCVEPR >CYP2D15 dog GenEMBL AB004268 Tasaki,T., Nakamura,A., Itoh,S., Ohashi,k., Yamamoto,Y., Masuda,M., Kazusaka,A., Kamataki,T. and Fujita,S. Expression and Characterization of Dog CYP2D15 Unpublished MGLLTGDTLGPLAVAVAIFLLLVDLMHRRRRWATRYPPGPTPVP MVGNLLQMDFQEPICYFSQLQGRFGNVFSLELAWTPVVVLNGLEAVREALVHRSEDTA DRPPMPIYDHLGLGPESQGLFLARYGRAWREQRRFSLSTLRNFGLGRKSLEQWVTEEA SCLCAAFAEQAGRPFGPGALLNKAVSNVISSLTYGRRFEYDDPRLLQLLELTQQALKQ DSGFLREALNSIPVLLHIPGLASKVFSAQKAIITLTNEMIQEHRKTRDPTQPPRHLID AFVDEIEKAKGNPKTSFNEENLCMVTSDLFIAGMVSTSITLTWALLLMILHPDVQRRV QQEIDEVIGREQLPEMGDQTRMPFTVAVIHEVQRFGDIVPLGVPHMTSRDTEVQGFLI PKGTTLITNLSSVLKDEKVWKKPFRFYPEHFLDAQGHFVKHEAFMPFSAGRRVCLGEP LARMELFLFFTCLLQRFSFSVPAGQPRPSDHGVFTFLKVPAPFQLCVEPR >CYP2D15 dog GenEMBL D17397 (1665bp) Sakamoto,K., Kirita,S., (Aoyama,J., Baba,T. and Matsubara,T.) cDNA cloning and characterization of dog P-450 2D. Arch. Biochem. Biophys. 319, 372-382 (1995) check authors on paper >AF029979 Lankford,S.M., Bai,S.A. and Goldstein,J.A. TITLE Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles JOURNAL Drug Metab. Dispos. 28 (8), 981-986 (2000) MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAK LAEQYGPVFTLYLGSQRTVVLHGYKAVKEVLLDHKNDLSGRGEVFAFQSHKDR GITFNNGPGWKDTRRLSLSTLRDYGMGKRGNEERIQREIPFLLEALRGTR GQPFDPTFLLGFAPFNVIADILFHKHFDYSDQTGLRIQKLFNENFHLLSTGWLQLY NIFPSYLHYLPGSHRKVLRNVAELKDYSLERVKEHQESLDPTCSRDFTDCLLQELQKE RYGTEPWYTLDNIAVTVADLFFAGTETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIG PSRVPAIKDRLEMPYMDAVVHEIQRFIDLLPSNLPHVANQDTMFRGYVIPKGTVVIPT LDSVLFDKQEFPDPEKFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLF LSAILQHFNLKSLVDPKDIDLSPCTIGFAKIPPHYKLCVVPRSG >CYP2E1v1 dog no accession number Susan M. Lankford and Stephen A. Bai submitted to nomenclature committee >AF029978 Lankford,S.M., Bai,S.A. and Goldstein,J.A. TITLE Cloning of canine cytochrome P450 2E1 cDNA: identification and characterization of two variant alleles JOURNAL Drug Metab. Dispos. 28 (8), 981-986 (2000) MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAK LAEQYGPVFTLYLGSQRTVVLHGYKAVKEVLLDHKNDLSGRGEVFAFQSHKDR GITFNNGPGWKDTRRLSLSTLRDYGMGKRGNEERIQREIPFLLEALRGTR GQPFDPTFLLGFAPFNVIADILFHKHFDYSDQTGLRIQKLFNENFHLLSTGWLQ LYNIFPSYLHYLPGSHRKVLRNVAELKDYSLERVKEHQESLDPTCSRDFTDCLLQELQK ERYGTEPWYTLDNIAVTVADLFFAGTETTSTTLRYGLLILMKYPEVE EKLHEEIDRVIGPSRVPAIKDRLEMPYMDAVVHEIQRFIDLLPSNLPHVANQDTMFRGYVIPK GTVVIPTLDSVLFDKQEFPDPEKFKPEHFLNENGKFKYSDYFKAFSA GKRVCVGEGLARMELFLFLSAILQHFNLKSLVDPKDIDLSPCTIGFAKIPPHHKLCVVPRSG >CYP2E1v2 dog no accession number Susan M. Lankford and Stephen A. Bai submitted to nomenclature committee note: only one amino acid difference with 2E1v1 >CYP2E1 AACN010451212.1 Canis familiaris ctg19866851310576, whole genome shotgun sequence Length = 1210 exon 1 64% to 2e1 176 MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAK 352 AJ402312 AJ402312 Canis familiaris liver Canis familiaris cDNA clone LEI122. Length = 490 EST 2E1 exon 1 24 ITVALLVWMATLMLISIWKQIYSRWKLXPGPFPLPIIGNILQVDIKNVPKSLAK 185 AJ402324 AJ402324 Canis familiaris liver Canis familiaris cDNA clone LEI184. Length = 494 exon 1 EST 68% to 2E1 exons 1-4 3 diffs near end 52 WKLPPGPFPLPIIGNILQVDIKNVPKSLAKLAEQYGPVFTLYLGSQRTVVLHGYKAVKEV 231 232 LLDHKNDLSGRGEVFAFQSHKDRGITFNNGPGWKDTRRLSLSTLRDYGMGKRGNEERIQR 411 412 EIPFLLEALKGNRGQPFDPNFLLGFAP 492 AACN010608941.1 Canis familiaris ctg19866850565291, whole genome shotgun sequence Length = 1031 exon 3 76% to 2E1 251 GITFNNGPGWKDTRRLSLSTLRDYGMGKRGNEERIQREIPFLLEALRGTR 102 >CYP2E1 AACN010571055.1 Canis familiaris ctg19866850492295, whole genome shotgun sequence Length = 1071 exon 6 77% to 2e1 475 ERYGTEPWYTLDNIAVTVADLFFAGTETTSTTLRYGLLILMKYPEVE 618 AJ402323 EXONS 8,9 EST Canis familiaris liver Canis familiaris cDNA clone 465 KPEXFLNENGKXKYSDXFKAXSAGKRVCVGEGXARMELFLFLSAILQHFNLKSLVDPKDI 286 285 DLSPCTIGFXKIPPHYKLCVVPRS 214 AACN011007565.1 Canis familiaris ctg19866850797479, whole genome shotgun sequence Length = 655 exon 9 83% to 2E1 418 GKRVCVGEGLARMELFLFLSAILQHFNLKSLVDPKDIDLSPCTIGFAKIPPHYKLCVVPR 239 >CYP2F AACN010013846.1 Canis familiaris ctg19866851879501, whole genome shotgun sequence Length = 4570 exons 1, 2 83% to 2F1 AACN010902592.1 Canis familiaris ctg19866851070117, whole genome shotgun sequence Length = 746 exon 3 90% to 2F1 AACN011054638.1 Canis familiaris ctg19866850632332, whole genome shotgun sequence Length = 571 exon 5 71% to 2F1P CE167218 tigr-gss-dog-17000326576196 Dog Library Canis familiaris genomic.Length = 683 exon 7 partial 92% to 2F1 runs off end AACN010807017.1 Canis familiaris ctg19866850927177, whole genome shotgun sequence Length = 831 Exon 8 93% to 2F1 AACN010968133.1 Canis familiaris ctg19866851744664, whole genome shotgun sequence Length = 694 exon 9 97% to 2F1 runs off end 1808 MDGVSTAILLGLLALAFLFLILNSRGKSQLPPGPRPLPFLGNLLQLRSQDMLTSLTK 1978 2073 LSKEYGSVYTVHLGPRRVVVLSGYQAVKEALVDQGEDFSGRGDYPVFFNFTKGNG 2237 429 GIAFSNGDRWKVLRRFSVQILRNFGMGKRSIEERILEEGSFLLAELRKTE 280 missing exon 4 459 LYNIFPSLLDWIPGPHRRLFQNFGCMKDLIARSVRDHQDSLDPRCPRDFIDCFLNKMAQVSLA 271 missing exon 6 ARVQEEIDXVVGRARLPALEDRAAMPYTDAVIHEVQRLADVIPMNLPHRVXXXXXXXXXXXXX 673 607 GTDIITLLNTVHYDPNQFLTPQEFNPEHFLDANQSFKKSPAFMPFSA 467 555 GRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLXXXXXXXXXXXXX 692 >CYP2G1 AACN010681921.1 Canis familiaris ctg19866851633434, whole genome shotgun sequence Length = 956 exon 1 86% to 2G1 mouse AACN010273103.1 Canis familiaris ctg19866851132553, whole genome shotgun sequence Length = 1611 exon 3 84% to 2G1 mouse AACN010949834.1 Canis familiaris ctg19866851535456, whole genome shotgun sequence Length = 710 exons 4, 5 89% to 2G2P AACN010208625.1 Canis familiaris ctg19866851107285, whole genome shotgun sequence Length = 1899 exon 6, 7 87% to 2G1 AACN010097049.1 Canis familiaris ctg19866850044586, whole genome shotgun sequence Length = 2693 exons 8,9 partial, only 2 diffs with 2G1P runs off both ends 187 MELGGAFTIFLALSLSCLLILIAWKRNSKGGKLPPGPTPIPFLGNVLQVRTDATFQSFMK 366 missing exon 2 1043 GVALANGERWRILRRFSLTILRDFGMGKRSIEERIQEEAGFLLEELRKTK 1192 2 XXXXEPTFFLSRTVSNVISSVVFGSRFDYEDKQFLKLLQMINESFIEMSTPWAQ 151 400 LYDMYSGIMQYLPGRHNRIYYLIEELKDFIASRVKINEASLDPQNPRDFIDCFLIKM 570 1889 TEFNLKNLVLTTLNLFFAGTETVSFTLRYGLLLMMKHPEVE 1767 238 AKIHEEIDQVIGPHRIPSVDDRAKMPYTDAVIHEIQRLTDIVPMGVPHNVIRDTHFRGYLLPK 50 (19 aa gap) 2692 YPDAFYPQHFLDEQGRFKKNEAFVPFSS 2609 100 GKRICLGEAMARMELFLYFTSILQNFSLHSLVP 2 (27 aa missing at C-term) >CYP2J AACN010094237.1 Canis familiaris ctg19866851022315, whole genome shotgun sequence Length = 2723 exon 4 80% to 2J2 AACN010532410.1 Canis familiaris ctg19866851051883, whole genome shotgun sequence Length = 1113 exon 5 77% to 2J2 AACN010292487.1 Canis familiaris ctg19866851635310, whole genome shotgun sequence Length = 1538 exon 6 90% to 2J2 AACN010411687.1 Canis familiaris ctg19866850575586, whole genome shotgun sequence Length = 1265 exon 7 81% to 2J2 80% to 2J2 1789 GQPFNPHFKINNAVSNIICSITFGKRFEYQDEQFQELLRLLDEVTCLETSMRCQ 1625 992 LYNVFPWIIKFLPGPHQKLFNDWEKLKLFIAHMTENHRRDWNPAEPRDFIDAYLKEMEKXX 816 960 GNATSSFHEENLIYSTLDLFFAGTETTSTTLRWGLLYLALNPEIQ 1094 1016 XXVQAEIDRVIGQSQLPGLAVRESMPYTNAFIHEVQRMGNIVPLNVPREVTGDTTLAGYYLP 837 >CYP2R1 AACN010509095.1 Canis familiaris ctg19866850347691, whole genome shotgun sequence Length = 1139 exon 2 92% to 2R1 AACN010551605.1 Canis familiaris ctg19866850732222, whole genome shotgun sequence Length = 1092 exon 3 runs off end AACN010339993.1 Canis familiaris ctg19866850455967, whole genome shotgun sequence Length = 1401 exons 4,5 C-term 95% to 2R1 runs off end missing exon 1 CE061184 tigr-gss-dog-17000322579837 Dog Library Canis familiaris genomic. Length = 372 exon 1 MAIDPGYQASGSAGRLKGELVPRRQRFPVPVSGPLGAEPGAGVLLGATLFPLLCEPGHR (frameshift) RLPFTSNIYSLAASGELAHVYMRKQSRVYXE 384 IFSLDLGGISAVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMG 524 (17 aa gap) 1090 AVNSFRCFGYGQKSFESKILEETNFFIDAIETYKGRPFDLKQLITNAVSNITNLIIFGERFTYEDTDFQH 881 880 MIELFSENVELAASASVFLYNAFPWIGIIPFGKHQQLFRNAAVVYDFLSRLIEKASINRK 701 700 PQSPQHFVDAYLNEMDQGKNDPSCTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALY 521 520 PNIQ 509 (30 aa gap) 1399 VLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRNPEIFYPE 1220 1219 RFLDSSGYFAKKEALVPFSL 1160 338 GRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR* 502 >CYP2S1 AACN010999381.1 Canis familiaris ctg19866850377732, whole genome shotgun sequence Length = 664 exon 2 83% to 2S1 AACN010282153.1 Canis familiaris ctg19866850672474, whole genome shotgun sequence Length = 1575 exons 3,4,5 2S1 87% to 2S1 AACN010825222.1 Canis familiaris ctg19866851783300, whole genome shotgun sequence Length = 813 exon 6 80% to 2S1 AACN011049752.1 Canis familiaris ctg19866851713998, whole genome shotgun sequence Length = 585 exon 7 86% to 2S1 AACN010471757.1 Canis familiaris ctg19866851432813, whole genome shotgun sequence Length = 1184 exons 8,9 83% to 2S1 missing exon 1 183 LSKKYGPVFTVYLGPWRRVVVLVGHEAVQEALGGQAEEFSGRGMLATLDGTFGGH 19 504 GVFFSNGERWRQLRRLTTLALRDLGMGKREGEELIQAEAQRLVEAFQGT 1071 GHPFDPSLLLAQATSNIICSLTFGLRFPYEDKEFQAVVQAAGGTVLGVSSPW 1226 1370 YEMFSWLLQHLPGPHTQLLSHLSVLATFAVQQVQRHKESLDTSGPPRDVVDAFLLKMAK 1546 644 EEQDPNTELTDKNLLMTVIYLLFAGTVTVSTTVRYTLLLLLKYPQVQ 784 45 VREELSRELGAGRAPGLGDRARLPYTDAVLHEAQRLLALVPMGVPRALARTT 200 GTEVFPLLGSVLHDPEIFDEPE 987 986 EFNPDRFLDADGRFQKQEAFLPFSL 912 756 GKRICLGEGLAHAELFLLLTTILQAFSLESPSPPGALSLQPAVSGLFNIPPAFQLRVRP 580 >CYP2T CE199997 tigr-gss-dog-17000372217101 Dog Library Canis familiaris genomic. Length = 493 exon 2 90% to 2T3P 45 LSGRWGPVFTVRLGPRPAVVLCGYSALRDALVLQADAFSGRGAMAVFERFTHGNG 209 >CYP2U1 dog GenEMBL AACN010459300.1 Canis familiaris ctg19866850044192, whole genome shotgun sequence Length = 1199 Exon 2 90% to 2U1 human aa 164-375 BM540113 EST covers exon 3 AACN010060907.1 Canis familiaris ctg19866851884649, whole genome shotgun sequence Length = 3143 Exons 4,5 93% to 2U1 missing exon 1 780 GIVFAHYGPVWKQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKEEMQKH 631 630 GEDPFNPFPIVNNAVSNIICSLCFGQRFDYTNSEFKKMLRLMSRALEICLNSQLLLVNI 454 453 CSWLYYLPFGPFKELRQIEKDITTFLKKIIKDHKESLNVENPQDFIDMYLLQVEEE 286 285 RKNNSNSSFNEDYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDIQ 145 EKVQEEIERVIGADRVPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSEKT 254 VLQGYTIPKGTVILPNLWSVHRDPAIWEKPDDFYPNRFLDDQGQLIKKETFIPFGI 421 GKRVCMGEQLAKMELFLMFVSLMQSFTFALPKDSKKPILTGRYGLTLAPHPFNIVISKR 2418 >CYP2W1 AACN010517201.1 Canis familiaris ctg19866850957159, whole genome shotgun sequence Length = 1130 exon 1 77% to 2W1 AACN010314449.1 Canis familiaris ctg19866851483397, whole genome shotgun sequence Length = 1469 exon 2 85% to 2W1 AACN010716778.1 Canis familiaris ctg19866850201752, whole genome shotgun sequence Length = 920 exons 6,7,8 87% to 2W1 323 MALLLLGILLLLGLWGLLQTCTRTPSSASRWPPGPRPLPLIGNLHLLRVSQQDQSLME 150 263 LSEQYGPVFTVHLGRQKTVVLAGYEAVREALVGTGPELADRPPIAIFQLIQGGGG missing exons 3-5 88 GKDPQGLFAEANMVACTLDMVMAGTETTSATLQWAALLMGKHPSVQ 341 GRVQEELDRVLGPGRAPQLEDQRSLPYTNAVLHEVQRFITLLPHVPRCMAADTQLGGYLLPK 526 695 GTPVIPLLSSVLLDKTQWETPRQFNPGHFLDAEGRFVKRAAFLPFSA 835 missing exon 9 >CYP2AB1P? AACN010195735.1 Canis familiaris ctg19866851231884, whole genome shotgun sequence Length = 1955 exons 8,9 75% to cyp2ab1 mouse 1543 GTIILPNLASVLLDPECWETPQQFNPGLFLDMGGNFLVNEAFLPFSA 1683 GHQVGPGDHLALMELFLMFANPFRTFWFQLPEGSLG*DLQYIWGTL*PQPQKICAVP 1941 >CYP2AC1 AACN010994363.1 Canis familiaris ctg19866851365239, whole genome shotgun sequence Length = 670 exon 1 69% to 2AC1P runs off end AACN011038787.1 Canis familiaris ctg19866851477972, whole genome shotgun sequence Length = 609 exon 2 86% to 2AC1P AACN011010355.1 Canis familiaris ctg19866851425659, whole genome shotgun sequence Length = 652 exon 3 82% to 2AC1P AACN010030717.1 Canis familiaris ctg19866850594957, whole genome shotgun sequence Length = 3793 exons 6,7,8 AACN010247777.1 Canis familiaris ctg19866850740503, whole genome shotgun sequence Length = 1725 exon 9 75% to 2AC1P human 174 MSGFDSSIILPILSLLLIFLLNIKIFMTKASKQHFPPGPRPLPIIGNLHILNXXXXXXXXXX 19 98 LSQKYGSIYSIQMGPKKVVVLSGYETVKDALVNYGDQFGERSQVPIFERLFEGK 259 277 GIVFSHGETWKTMRRFSLATLRNFGMGKRIIEDTIIEECQHLIWSFESHR 128 missing exons 4, 5 336 EKDTSTTYFSDENLVALVSNLFAAGTETTATTLCWALLLMMRYPEVQS 479 855 KVCDEITKVVGSAQPRITHRTQMPYTDAVIHEVQRFANILPTGLPHATTTNVMFKNYYIPK 1037 2866 GTEVITLLTSVLRDQTQWEKPDTFNPNHFLSSTGKFIKKEAFMPFSL 3006 1018 GRRMCAGESLAKMELFLFFTSLMQKFTFQPPPGVSHLDLDLTPDIGFTTRPMPHKICALLRA* 830 XM_847513 lower case fills in missing seq above. N-term may be too long MTMQAAALGSSIGSAIAGGLITGLILRFIVRGQPSKDNFFDDSVYWEVLDFYYLNNYVYVEI MSGFDSSIILPILSLLLIFLLNIKIFMTKASKQHFPPGPR PLPIIGNLHILNlkrpyqtmleLSQKYGSIYSIQMGPKKVVVLSGYETVKDALVNYGD QFGERSQVPIFERLFEGKGIVFSHGETWKTMRRFSLATLRNFGMGKRIIEDTIIEECQ HLIWSFESHR gkpfevktvmnasvanvivsvllgkrfdyqdtqflrlltligenvkli ggprialfnmfpvlgfllkshktvlrnrdelfafirmtfldhqhkfdkndprsfidaf lvrqqe EKDTSTTYFSDENLVALVSNLFAAGTETTATTLCWALLLMMRYPEVQKKVCD EITKVVGSAQPRITHRTQMPYTDAVIHEVQRFANILPTGLPHATTTNVMFKNYYIPKG TEVITLLTSVLRDQTQWEKPDTFNPNHFLSSTGKFIKKEAFMPFSLGRRMCAGESLAK MELFLFFTSLMQKFTFQPPPGVSHLDLDLTPDIGFTTRPMPHKICALLRA* >CYP3A12 dog GenEMBL X54915 Ciaccio,P.J., Graves,P.E., Bourque,D.P., Glinsmann-Gibson,B. and Halpert,J.R. cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily Biochim. Biophys. Acta 1088 (2), 319-322 (1991) MDLIPSFSTETWLLLAISLVLLYL YGTYTHGIFRKLGIPGPTPLPFVGTALGYRN GFYVFDMKCFSKYGRMWG FYDGRQPVLAITDPDMIKTVLVKECYSVFTNRR TLGPVGFMKSAISLSEDEEWKRMRTLLSPTFTTGKLKE MFPIIGQYGDVLVNNLRKEAEKGKAINLKD VFGAYSMDVITSTSFGVNIDSLNHPQDPFVENTKKLLKFDFLDPFFFSI LLFPFLTPVFEILNIWLFPKKVTDFFRKSVERMKESRLKDKQK HRVDFLQLMINSQNSKEMDTHK ALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQQKLQEEIDATFPNK ALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPEPEEFRPER FSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQ IPLKLNAQGIIQPEKPIVLKVEPRDGSVNGA >CYP3A12 dog PIR S04341 (28 amino acids) Ciaccio, P.J. and Halpert, J.R. Characterization of a phenobarbital-inducible dog liver cytochrome P450 structurally related to rat and human enzymes of the P450IIIA (steroid-inducible) gene subfamily. Arch. Biochem. Biophys. 271, 284-299 (1989) >CYP3A26 AF547269 Fraser,D.J., Feyereisen,R., Harlow,G.R. and Halpert,J.R. TITLE Isolation, heterologous expression and functional characterization of a novel cytochrome P450 3A enzyme from a canine liver cDNA library JOURNAL J. Pharmacol. Exp. Ther. 283 (3), 1425-1432 (1997) MDLIPSFSTETWLLLAISLVLLYL YGTYTHGIFRKLGIPGPTPLPFVGTALGYRN GFYVFDMKCFSKYGRMWG FYDGRQPVLAITDPDMIKTVLVKECYSVFTNRR TLGPVGFMKSAISLSEDEEWKRIRTLLSPTFTTGKLKE MFPIIGQYGDVLVNNLRKEAEKGKAINLKD VFGAYSMDVITSISFGVNIDSLNHPQDPFVENTKNLLKFDFLDPFLFSI LLFPFLTPVFEILNIWLFPKKVTDFFRKSVERMKESRLKDKQK HRVDFLQLMINSQNSKEMDTHK ALSDLELVAQSIVFIFAGYETTSSCLSFLMYELATHRDVQQKLQEEIDATFPNK AAPTYEALVQMEYLDMVLNETLRLYSVAGRLERVCKKDVEISGVFIPKGTVVMVPTFILHRDQNLWPEPEEFRPER FSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKSCKETQ ISLRINTRGIIQPEKPVVLKVEPRDGSVSGA >CYP3A26 dog no accession number David Fraser submitted to Nomenclature Committee 95.6% identical to 3A12 from dog >CYP3A26 AACN010252256.1 Canis familiaris ctg19866851674710, whole genome shotgun sequence Length = 1704 exon 4 AACN010191886.1 Canis familiaris ctg19866850837924, whole genome shotgun sequence Length = 1973 exons 5, 6 AACN010399536.1 Canis familiaris ctg19866850840232, whole genome shotgun sequence Length = 1284 exon 7 AACN010287562.1 Canis familiaris ctg19866850795341, whole genome shotgun sequence Length = 1555 exon 8 AACN010174600.1 Canis familiaris ctg19866850999372, whole genome shotgun sequence Length = 2065 exon 9 AACN010050790.1 Canis familiaris ctg19866850715504, whole genome shotgun sequence Length = 3321 exon 10, 11 AACN010751339.1 Canis familiaris ctg19866851566000, whole genome shotgun sequence Length = 886 exon 12 partial AACN011064056.1 Canis familiaris ctg19866851839659, whole genome shotgun sequence Length = 537 exon 13 3A26 missing exons 1-3 1326 FYDGRQPVLAITDPDMIKTVLVKECYSVFTNRR 1424 525 TLGPVGFMKSAISLSEDEEWKRIRTLLSPTFTTGKLKE 411 166 MFPIIGQYGDVLVNNLRKEAEKGKAINLKE 77 200 VFGAYSMDVITSISFGVNIDSLNHPQDPFVENTKNLLKFDFLDPFLFSI 54 894 VLFPFLTPVFEILNIWLFPKKVTDFFRKSVERMKESRLKDKQK 1022 953 HRVDFLQLMINSQNSKEMDTHK 888 2231 ALSDLELVAQSIVFIFAGYETTSSCLSFLMYELATHRDVQQKLQEEIDATFPNK 2070 274 AAPTYEALVQMEYLDMVLNETLRLYSVAGRLERVCKKDVEISGVFIPKGTVVMVPTFIL 98 97 HRDQNLWPEPEEFRPKG 2 (25 aa gap) GMRFAIMNMKLALVRVLQNFSFKSCKETQ 88 300 ISLRINTRGIIQPEKPVVLKVEPRDGSVSGA 392 >CYP3A12 AACN010053444.1 Canis familiaris ctg19866850669043, whole genome shotgun sequence Length = 3271 exon 11 AACN010266987.1 Canis familiaris ctg19866850931957, whole genome shotgun sequence Length = 1636 exon 12 AACN010902297.1 Canis familiaris ctg19866850587579, whole genome shotgun sequence Length = 746 3A12 exon 13 1216 ALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTL 1392 1393 HRDQSLWPEPEEFRPER 1443 766 FSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQ 930 403 IPLKLNAQGIIQPEKPIVLKVEPRDGSVNGA 311 >CYP3a dog seq a plus Seq f exons 12-13 not 3A12 or 3A26 so add to seq a AC131027.14 MDLIPSFSTETWLLLATSLVLFYL YGTYTHGLFKKLGIPGPTPLPFLGTVLGY QGFCDFDEKCFRKYGRMWG FYDGRQPVLAIMDPDMIKTVLVKECYSVFTNRR XFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKE MFPIIGQYGDMLVRNLRKEAEKGKAISLKE IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSI VLFPFLTPLYEMLNIWLFPKKITDFFTKSVKRMKESRLKDKQK HRVDFLQLMINSQNSKEMNTHK ALSDLELVAQSIIFIFGGYETTSTSLCLLMYELATQPDVQQKLQKEIDATFPNK AAPTYEALVQMEYLDMVLNESLRLYPIAGRLERVCKKDVEISGVFIPKGTLVVVPTFTF HRDLDLWPEPEEFQPER RFSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQ IPLKLSSQGLIRPEEPIVLNVEPRDGSVXXX >CYP3A new matches seq a AACN010002469.1 Canis familiaris ctg19866851879211, whole genome shotgun sequence Length = 6257 exon 1 4008 MDLIPSFSTETWLLLATSLVLFYL 4079 >CYP3A new not 12, 26 or a = 4th gene AACN010055666.1 Canis familiaris ctg19866851088716, whole genome shotgun sequence Length = 3232 exon 1 1082 MDLIPSFSMETWLLLATSLVLLYL 1011 >CYP3A new not 12, 26 or a AACN010330145.1 Canis familiaris ctg19866850928392, whole genome shotgun sequence Length = 1426 exon 2 93% to 3A12 and 3a26 YGTYTHGVFKKLGIPGPTPLPFVGTALGYR 138 >CYP3A new = seq a AACN010186119.1 Canis familiaris ctg19866850051573, whole genome shotgun sequence Length = 2001 exon 2 87% to CYP3A12 and 3A26 YGTYTHGLFKKLGIPGPTPLPFLGTVLGYRN 1175 >CYP3A new not 12, 26 or a AACN010232554.1 Canis familiaris ctg19866850875804, whole genome shotgun sequence Length = 1796 exon 3 269 GFSVFDENCFRKYGRMWG 216 >CYP3A new not 12, 26 or a AACN010654075.1 Canis familiaris ctg19866850838678, whole genome shotgun sequence Length = 984 exon 3 653 GFCDFDEKCFRKYARTWG 600 >CYP3a new not 12, 26 or a AACN010195862.1 Canis familiaris ctg19866850545141, whole genome shotgun sequence Length = 1954 exon 5 89% to 3a26 87% to 3a12 354 SFGPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEV 235 >CYP3A new only 2 diffs with seq a AACN010061832.1 Canis familiaris ctg19866851896773, whole genome shotgun sequence Length = 3129 exons 5,6 86% to 3A26, 85% to 3A12 1171 SFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKE 1284 1542 MFPIIGQYGDVLVRNLRKEAEKDKAISLKE 1631 >CYP3A new matches seq a AACN010011846.1 Canis familiaris ctg19866850279032, whole genome shotgun sequence Length = 4718 exons 7,8,9 87% to 3a12 86% to 3a26 4627 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSI 3487 VLFPFLTPLYEMLNIWLFPKKITDFFTKSVKRMKESRLKDKQK 3364 2265 HRVDFLQLMINSQNSKEMNTHK 2200 >CYP3A new not 12, 26 or a AACN010374456.1 Canis familiaris ctg19866850452873, whole genome shotgun sequence Length = 1328 exon 8 86% to 3a12 and 3a26 VLFPFLTPVFEVLNIWLFPKSVTDFFTKSVKRMKENRLKDKQK 998 >CYP3A new not 12, 26 or a AACN011052580.1 Canis familiaris ctg19866850605075, whole genome shotgun sequence Length = 577 exon 11 85% to 3A12 81% to 3A26 445 AAPTYDTLVQMEYLDMVLNESLRLYPITGRLVRVCKKDVEISGVFIPKGTVVMVPTFTL 269 268 HQDPDIWPEPEKFQPER 218 >CYP3A new = seq a AACN010213676.1 Canis familiaris ctg19866850042623, whole genome shotgun sequence Length = 1877 exon 12 1270 FSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQ 1109 >CYP3A new = seq a AACN010220406.1 Canis familiaris ctg19866850579309, whole genome shotgun sequence Length = 1849 exon 12 175 FSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQ 14 >CYP3A new not 12, 26 or a AACN010243485.1 Canis familiaris ctg19866850390339, whole genome shotgun sequence Length = 1745 exon 13 61% to 3A4 last exon 77% to 3a12 72% to 3a26 21 LRVNST-----EEPIILNVEPRDGSVRGA 92 >CYP4A genes. There are at least 3 genes in the 4A subfamily and maybe more. AACN010025457.1 Canis familiaris ctg19866851895070, whole genome shotgun sequence Length = 3973 exon 1 75% to 4A22 1654 MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQHRQWLLKAVQQFPSPPSHWFFGHKQE 1460 AACN010004769.1 Canis familiaris ctg19866850259111, whole genome shotgun sequence Length = 5615 exon 1 73% to 4A22 4260 MSVSLLSLTRPLDTVSGFLQVASLLGLALLLLKAAQFYWHRQWLLKAIQQFPSPPSHWFFGHRQE 4066 830 ELQVFQKWTEKYPCACPRWLWGSRVSLVVYDPDYMKMILGRS 705 AACN010319098.1 Canis familiaris ctg19866851702217, whole genome shotgun sequence Length = 1456 exon 1 67% to 4A11 1310 MSVSVLSLTRPLDTVSGLLQLASLLSLALLLLKTAQLYQRRQWMLKAIQ 1456 AACN010355109.1 Canis familiaris ctg19866850670552, whole genome shotgun sequence Length = 1367 exons 2,3 291 LQKGDELQLLLKWIQDFPCAFSRWIWGTEAEIVIYDPDYMKLILGR 443 1208 SDPKSDGSYKLMAPWI 1255 AACN010965485.1 Canis familiaris ctg19866851394562, whole genome shotgun sequence Length = 697 exon 3 82% to 4A11 309 SDPKSDGSYRLMAPWI 262 AACN010323944.1 Canis familiaris ctg19866850426197, whole genome shotgun sequence Length = 1442 exon 4 90% to 4A11 Sbjct: 1297 GYGLLLLHGETWFQHRRMLTPAFHYDILKPYVRLMADSVQVM 1422 AACN010864510.1 Canis familiaris ctg19866850426193, whole genome shotgun sequence Length = 777 exon 5 76% to 4A11 132 DKWEELVTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR 257 AACN010405105.1 Canis familiaris ctg19866850426191, whole genome shotgun sequence Length = 1275 exon 5 76% to 4A11 1081 DKWEELVTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR 1206 AACN010353628.1 Canis familiaris ctg19866850542017, whole genome shotgun sequence Length = 1370 exon 6,7,8,9 83% to 4A11 135 NSQAYIQAIRDLNNLVFARVRNVFYQKDIFYGLTSEGRRNHKACQLAHEHT 287 723 DRVIKLRKAQLQDEGELEKIRNKRHLDFLDILLFAK 830 926 MENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW 1114 1209 EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPK 1340 AACN010596498.1 Canis familiaris ctg19866850462770, whole genome shotgun sequence Length = 1044 exons 6,7,8 80% to 4A11 945 NSQAYIQAIRDMNNLVFARVRNVFYQKDIFYGLTSEGRRNHKARQIAHQHT 793 354 DRVIKLRKAQLQDEGELEKVRNKRHLDFLDILLFAK 247 155 MENGKGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREE 3 AACN010562135.1 Canis familiaris ctg19866851080478, whole genome shotgun sequence Length = 1081 exons 6,7 77% to 4A11 223 NFQSYIQAIKDLNYLVFSRMRNVFYQKDIFYWLTSEGRRNHKACQLAHEHT 375 817 D*VIKLRKAQLQEEEEPEKVRNKRHLDFLDILLLAK 924 CE047857 tigr-gss-dog-17000357493730 Dog Library Canis familiaris genomic. Length = 482 exons 8,9 88% to 4A11 467 MENGRGLSDKDLRAEVDTFKFEGHDTTASGISWILYILATHPEHQQRCREEIQSLLGDGASITX 279 165 XHLDQMPYTTMCIKEALRLYLPVPTVGRELSKPITFPDGRSLPR CE152057 tigr-gss-dog-17000371341724 Dog Library Canis familiaris genomic. Length = 693 exon 8 partial , exon 9 93% to 4A11 MENGKGLSDKDLRAEVDT XHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPK AACN010553294.1 Canis familiaris ctg19866850462768, whole genome shotgun sequence Length = 1090 exon 9 9 HLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPK CE234625 tigr-gss-dog-17000333373794 Dog Library Canis familiaris genomic. Length = 704 Exons 10,11 81% to 4A11 GFLVLLSFYALHHNPNVWPNPE VFDPSRFAPDASRHSHAFLPFSGGSR AACN010901969.1 Canis familiaris ctg19866851858928, whole genome shotgun sequence Length = 746 exons 10, 11 586 GFLVSLSFYALHHNPNVWPNPE 515 VFDPSRFAPDASRHSHAFLPFSGGSR 303 AACN010024457.1 Canis familiaris ctg19866851889191, whole genome shotgun sequence Length = 4011 exons 10, 11 2061 GFLVLLSFYALHHNPNVWPNPE 2126 VFDPSHFAPDASRHSHAVLPFSGGAR 2343 AACN010540669.1 Canis familiaris ctg19866851139202, whole genome shotgun sequence Length = 1104 exons 10,11 GFLVLLSFYALHHNSNVWPNPE VFDPSRFAPDASRHSHAFLPFSGGSR 346 4A exons 10,11 CE234625 GFLVLLSFYALHHNPNVWPNPE VFDPSRFAPDASRHSHAFLPFSGGSR AACN010901969.1 GFLVSLSFYALHHNPNVWPNPE VFDPSRFAPDASRHSHAFLPFSGGSR 303 AACN010024457. GFLVLLSFYALHHNPNVWPNPE VFDPSHFAPDASRHSHAVLPFSGGAR 2343 AACN010540669.1 GFLVLLSFYALHHNSNVWPNPE VFDPSRFAPDASRHSHAFLPFSGGSR 346 AACN010254948.1 Canis familiaris ctg19866850191380, whole genome shotgun sequence Length = 1690 exon 12 27 NCIGKHFAMNEMKVAVALTLLRFELAPDPFRIPVPTPRIVLMSKNGIHLHLRKLL* 188 AACN010373352.1 Canis familiaris ctg19866850191378, whole genome shotgun sequence Length = 1330 exon 12 297 NCIGQHFALKEMKVAVALTLLRFELAPDPFRIPVPTPRIVLMSKNGIHLHLRKLL* 458 CE327517 tigr-gss-dog-17000333945651 Dog Library Canis familiaris genomic. Length = 290 Exon 12 74% to 4A11 RNCIGQHFAMN*LKVTVALTLLRFELAPDPFRIPVPTPRIVLM 108 107 SKNGIHLHLRKL 72 AACN010192013.1 Canis familiaris ctg19866850418412, whole genome shotgun sequence Length = 1972 exon 12 1867 GKHFAMNELKVAVALTLLRFELAPDPF 1787 1785 KIPVPTPRIVLMSKNGIHLHLRKL 1714 AACN010188536.1 Canis familiaris ctg19866850191374, whole genome shotgun sequence Length = 1989 exon 12 33 HFALNELKVAVALTLLRFELAPDPFRIPVSTPKIVLMSKNGIHLHLRKL 179 CE064315 tigr-gss-dog-17000322608255 Dog Library Canis familiaris genomic. Length = 547 Exon 12 partial 75% to 4A11 NELKVAVALTLLRFELAPDPFRIPVSTPKIVLMSKNGIHLHLRKL 468 AACN010571884.1 Canis familiaris ctg19866850191376, whole genome shotgun sequence Length = 1070 exon 12 NCIGQHFAMNELKVAVALTLLRFELAPDPFRIPVPTPRI 3 >CYP4B1 CE343572 tigr-gss-dog-17000334109560 Dog Library Canis familiaris genomic. Length = 185 exon 1 78% to 4B1 runs off end AACN010130281.1 Canis familiaris ctg19866850769242, whole genome shotgun sequence Length = 2387 exon 2, 3 AACN010494378.1 Canis familiaris ctg19866851784262, whole genome shotgun sequence Length = 1156 exon 4 83% to 4B1 AACN010621190.1 Canis familiaris ctg19866850553752, whole genome shotgun sequence Length = 1018 exons 5, 6, 7 86% to 4B1 AACN010634041.1 Canis familiaris ctg19866851216077, whole genome shotgun sequence Length = 1005 exon 8 92% to 4B1 AACN011045402.1 Canis familiaris ctg19866851355221, whole genome shotgun sequence Length = 595 exon 10, 11 partial runs off end 173 MVSTLLSLSVSHLVLWATGLILVLGFLKLIRLLLRRQMLARAMDSFPGPPTHWLFGHXXX 3 489 IQQTGSLDKVVTWAHQYDYAHPLWLGPFLGFLNIYEPDYAKAVYSRG 349 172 DPKAADVYDFFLQWIG 125 867 KGLLVLQGPKWYQHRKLLTPGFHYDVLKSYVAVFTNSTHAML 742 115 DKWEEKAREDKSFDIFCDVGYMALDSLMKCTFGKGDSSLGHR 240 544 RDSSYYSAVRDLTLLMQQRIESFQYHNDFIYWLTPHGRRFLRACQAAHDHT 696 847 DQVIRERKAALQDEKEQEKIQNRRHLDFLDILQGAR 954 638 DENGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPQHQHRCREEVCEIXXXXXXXXX 802 missing exon 9 216 GSLISLHIYALHRNSAVWPDPE 151 50 VFAPLRFSSENVARRHXXXXXXXXXXXX 3 missing exon 12 >CYP4B pseudogene AACN010025457.1 Canis familiaris ctg19866851895070, whole genome shotgun sequence Length = 3973 exon 1, 2 pseudogene fragment like 4B1 ASLLGLALLLLKAAQLYQHRQWLLKAVQQFPSPPSHWFFGHKQEV QFPYAHPLWFGPFLGFLNICEPDLSKVWYS*G >CYP4B pseudogene AACN010277497.1 Canis familiaris ctg19866851121684, whole genome shotgun sequence Length = 1593 exon 2 77% to 4B1 pseudogene fragment 1486 Q*TGNLDKVVSWARQFSYA 1542 1542 HPLWFGLFLGFLYICEP 1592 >CYP4B pseudogene AACN010480974.1 Canis familiaris ctg19866850052317, whole genome shotgun sequence Length = 1172 exon 2 77% to 4B1 partial may be a pseudogene HQFPYAHPLWFGPFLGFLNICEPDFSKVWYS*G 345 >CYP4B pseudogene AACN010003495.1 Canis familiaris ctg19866850052316, whole genome shotgun sequence Length = 5930 exon 2 72 % to 4B1 may be a pseudogene 5929 SWAPFPYAHPLWFGPFLGFLNICEPDFSKVWYS*G >CYP4F22 ortholog AACN010935863.1 Canis familiaris ctg19866851816712, whole genome shotgun sequence Length = 720 Exon 1 82% to 4F22 MLPITE 679 TLLHLLGMEKTAFRLYAVSMLLLSLLFFSFRLLIQFLRFCWRFYITCRRLSCFPQPPRRNWLLGHLGM 470 AACN010415404.1 Canis familiaris ctg19866850137970, whole genome shotgun sequence Length = 1260 Exon 2 91% to 4F22 YLPNETGLQDEKKVLDNMHHVILVWIGPVLPLLVLVHPDYIKPLVGAS 743 AACN010397206.1 Canis familiaris ctg19866851045152, whole genome shotgun sequence Length = 1288 Exons 3,4,5 87% to 4F22 LPLPPRNDLFYGFLKPWLG DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQCTDIM 812 597 KWRCLAQGSVISLDMFEHVSLMTLDSLQKCVFSYNSNCQE 478 AACN010397206.1 Canis familiaris ctg19866851045152, whole genome shotgun sequence Length = 1288 exon 4 95% to 4F22 934 DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQCTDIM 812 AACN010124695.1 Canis familiaris ctg19866851268927, whole genome shotgun sequence Length = 2435 exons 6,7,8 91% to 4F22 466 KMSDYISAIIELSALVVRRQYRLHHHIDFIYYLTADGRRFRQACDTVHRFTTEVIQERRQ 645 646 ALRQQGAETWLKGKQGKTLDFIDVLLLAR 732 1741 DEDGRELSDEDIRAEADTFMFE 1806 1917 GHDTTSSGLSWVLFNLAKYPEYQEKCREEIQEVMKGRELEELEW 2048 AJ411545.1 CFA411545 Canis familiaris STS REN249H14, sequence tagged site Length = 775 exon 9 from dbSTS 326 DDLTQLPFTTMCIKESLRX 273 270 FPPVTLVSRRCTEDIKLPDGRIIPK 196 AACN010637808.1 Canis familiaris ctg19866851074287, whole genome shotgun sequence Length = 1001 exon 10 209 GIICLVSIYGTHHNPTVWPDSK 144 AACN010241790.1 Canis familiaris ctg19866850845244, whole genome shotgun sequence Length = 1753 Exons 11, 12 93% to 4F22 334 VYNPYRFDPDNPQQRSPLAYVPFSAGPR 417 NCIGQSFAMAEMRVAVALTLMRFRLSVDRTRKVRRKPELILRTESGIWLNVEPLPPRA 960 >CYP4F22 ortholog 89% to 4F22 63% to 4F3 MLPITETLLHLLGMEKTAFRLYAVSMLLLSLLFFSFRLLIQFLRFCWRFYITCRRLSCFPQPPRRNWLLGHLGM 470 YLPNETGLQDEKKVLDNMHHVILVWIGPVLPLLVLVHPDYIKPLVGAS 743 LPLPPRNDLFYGFLKPWLG DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQCTDIM 812 597 KWRCLAQGSVISLDMFEHVSLMTLDSLQKCVFSYNSNCQE 478 466 KMSDYISAIIELSALVVRRQYRLHHHIDFIYYLTADGRRFRQACDTVHRFTTEVIQERRQ 645 646 ALRQQGAETWLKGKQGKTLDFIDVLLLAR 732 1741 DEDGRELSDEDIRAEADTFMFE 1806 1917 GHDTTSSGLSWVLFNLAKYPEYQEKCREEIQEVMKGRELEELEW 2048 326 DDLTQLPFTTMCIKESLRXFPPVTLVSRRCTEDIKLPDGRIIPK 196 209 GIICLVSIYGTHHNPTVWPDSK 144 334 VYNPYRFDPDNPQQRSPLAYVPFSAGPR 417 NCIGQSFAMAEMRVAVALTLMRFRLSVDRTRKVRRKPELILRTESGIWLNVEPLPPRA 960 CE387110 tigr-gss-dog-17000334401226 Dog Library Canis familiaris genomic. Length = 475 exon 1 extreme N-term 81 MLQLSLSWLGLGQLAISPWVLLLRWG 4 AACN010455794.1 Canis familiaris ctg19866851299585, whole genome shotgun sequence Length = 1204 exon 1 partial 1203 VLLLLAGATWLLARVLTWSYSFYDNCCRLRCFPQPPKRNWFWGHLGL 1063 AACN010530471.1 Canis familiaris ctg19866850788149, whole genome shotgun sequence Length = 1115 Exons 3,4 78% to 4F2 (not the 4F22 ortholog) 767 SATIVPKDMFFYNFLKPWLG 614 DGLLLSAGDKWSHHRRLLTPAFHFEILKSYVKIFNRSADIM 492 AACN010304672.1 Canis familiaris ctg19866851394333, whole genome shotgun sequence Length = 1498 exons 5, 6 75% to 4F11 (not the 4F22 ortholog) Note 78% to 4F3 in overlap with other exon 6 261 AKWKRLVSEGSTHLDMFEHISLMTLDSLQKCVFSFDSNCQE 383 1241 XXSEYIAAILELSALVVKRNEQVLLYLDFLYNLSPDGRRFRRACELVHNFTDAIIQERRHTL 1420 1421 ISRGSCDFLKSKTRTSLXXXXXXXXXX 1471 AACN010644044.1 Canis familiaris ctg19866851850186, whole genome shotgun sequence Length = 994 Exons 5,6 89% to 4F3 (not the 4F22 ortholog) Note 89% to 4F3 in overlap of exon 6 994 XXXXRLVSEGSTHLDMFEHISLMTLDSLQKCVFSFDSNCQE 884 117 KPSEYIAAILELSALVAKRHQQILHMDFLYYLTPDGQRF 1 AACN010556807.1 Canis familiaris ctg19866851748017, whole genome shotgun sequence Length = 1086 Exons 7,8 91% to 4F2 (not the 4F22 ortholog) 418 DEDGKQLSDKDIRAEADTFMFE 353 121 GHDTTASGLSWVLFNLAKHPEYQERCRQEVQELLRDRE 8 CE214916 tigr-gss-dog-17000372909364 Dog Library Canis familiaris genomic. Length = 556 Exon 8 partial 91% to 4F12 (not the 4F22 ortholog) 136 GHDTTASGLSWVLFNLAKHPEYQERCRQEVQELLRD 243 AACN010925329.1 Canis familiaris ctg19866851748015, whole genome shotgun sequence Length = 728 exon 8 90% to 4F8 (not the 4F22 ortholog) 641 GHDTTASGLSWVLFNLAKHPEYQERCRQEVQELLRDREPQEIEW 510 AACN010840222.1 Canis familiaris ctg19866850335779, whole genome shotgun sequence Length = 799 Exon 8 90% to 4F8 (not the 4F22 ortholog) 688 GHDTTASGLSWVLFNLAKHPEYQERCRQEVQELLRDREPQEIEW 557 AACN010746253.1 Canis familiaris ctg19866851463212, whole genome shotgun sequence Length = 891 Exons 9, 10 86% to 4F3 (not the 4F22 ortholog) 392 DDLAKLPFLTMCIKESLRLHPPVTVISRCCTQDIVLSDGRVIPK 523 618 GVTCLISIFGTHHNPSVWPDPE 683 CYP4F2,3,8,11,12 ortholog There are two different exons 6 so there may be two genes 77% to 4F3 MLQLSLSWLGLGQLAISPW 1203 VLLLLAGATWLLARVLTWSYSFYDNCCRLRCFPQPPKRNWFWGHLGL 1063 missing exon 2 767 SATIVPKDMFFYNFLKPWLG 614 DGLLLSAGDKWSHHRRLLTPAFHFEILKSYVKIFNRSADIM 492 261 AKWKRLVSEGSTHLDMFEHISLMTLDSLQKCVFSFDSNCQE 383 1241 XXSEYIAAILELSALVVKRNEQVLLYLDFLYNLSPDGRRFRRACELVHNFTDAIIQERRHTL 1420 1421 ISRGSCDFLKSKTRTSLXXXXXXXXXX 1471 418 DEDGKQLSDKDIRAEADTFMFE 353 121 GHDTTASGLSWVLFNLAKHPEYQERCRQEVQELLRDREXXXXX 8 392 DDLAKLPFLTMCIKESLRLHPPVTVISRCCTQDIVLSDGRVIPK 523 618 GVTCLISIFGTHHNPSVWPDPE 683 missing exons 11,12 >CYP4V AACN010095657.1 Canis familiaris ctg19866850163616, whole genome shotgun sequence Length = 2707 exon 1 CYP4V AACN010593213.1 Canis familiaris ctg19866851382751, whole genome shotgun sequence Length = 1048 exon 3 CYP4V AACN010708847.1 Canis familiaris ctg19866850274743, whole genome shotgun sequence Length = 928 exon 5 CYP4V AACN010134828.1 Canis familiaris ctg19866851886518, whole genome shotgun sequence Length = 2349 exon 7 67% to 4V2 AACN010102290.1 Canis familiaris ctg19866851073691, whole genome shotgun sequence Length = 2640 exon 8 87% to 4V2 AACN010289085.1 Canis familiaris ctg19866850314690, whole genome shotgun sequence Length = 1549 exons 9, 10 85% to 4V2 AACN010289085.1 Canis familiaris ctg19866850314690, whole genome shotgun sequence Length = 1549 exon 11 CYP4V AACN010347037.1 Canis familiaris ctg19866850911762, whole genome shotgun sequence Length = 1385 exon 12 84% to 4V2 131 MPALWLVPLGQKLLLWGALGAASLAGATLVVRLLQMLASYAQKWQQMRAVPTLPGAYPLVGHSLLMKPDGR 343 missing exon 2 787 ILTSSRQIDKSYVYKFLEPWLGLGLLT 707 missing exon 4 204 ETAMGKNIGAQNNEDSEYVRAIYR 275 missing exon 6 1105 VITERASELKRDEEHGSADKDCSPSKNKRRAFLDLLLNVTDDEGNKLRHEDVREEVDTFMFE 920 387 GHDTTAAAINWSLYLLGSYPEVQKQVDSELEDV 485 972 KSDRPATLEDLKKLKYLECVIKESLRLFPSVPLFARNLNED 1094 1184 YLLTAGYKVVKGSQAIIIPYALHRDPRYFPNPEEFQPERFFPENLQG 1324 1325 RHPYAYIPFSAGPRNCIG 1378 438 QRFAIMEEKTVLSCVLRHFWVESNQKREELGLAGELILRPTNGIWIKLKRRNADE 274 >CYP4X1 AACN010211165.1 Canis familiaris ctg19866851283898, whole genome shotgun sequence Length = 1888 exon 1 89% to 4X1 AACN010063288.1 Canis familiaris ctg19866850125443, whole genome shotgun sequence Length = 3107 exon 2 73% to 4X1 AACN010049021.1 Canis familiaris ctg19866851888974, whole genome shotgun sequence Length = 3353 Exons 5, 6 68% to 4X1 AACN010064928.1| Canis familiaris ctg19866850361801, whole genome shotgun sequence Length = 3081 Exons 7, 8 69% to 4X1 AACN010009337.1 Canis familiaris ctg19866851879687, whole genome shotgun sequence Length = 4948 exon 9 75% to 4X1 AACN010022403.1 Canis familiaris ctg19866850698800, whole genome shotgun sequence Length = 4097 exons 11, 12 82% to 4X1 1111 MESSWLETRWARPLYLAFAFCLALGLLQAIKLYLRRLRLLRDLCPFPAPPTHWFYGHQK 935 1248 XLQDGKIEKLEELVEKYPCAFPYWVGPFQAFFYIYDPDYAKTFLGRT 1111 missing exons 3,4 1359 KWEKICGTQDTVVEVFEHINLMTLDVLMKCAFSQETNCQIS SNHDLYVKTTFEASKINFYRLYSFLHHHDIIFKFSPQGHRLQELVKILHQYTGT 991 2033 VIQDRKKLLKDEKKHGNTQKRKDQDYLDIILSAQ 2134 2695 XENGNSFSDTDLRSEVNTFILAGHDTMAGSISWLLYHLALNPEHQERCRQEIRGILRDRSSITW 2883 2679 DQLGEMSYTTMCIKESLRLAPPIPSISRELSKPITFPDGRSLPA 2810 missing exon 10 670 VFDPLRFSQENSDQRHTHSFLPFSAGPR 753 1591 NCIGQHFAMVKLKVAIALILLHFKVSPDPTRPLVFLHQIVLKPKNGVHLHLKKL 1752 >CYP5A1 AACN010011564.1 Canis familiaris ctg19866850208464, whole genome shotgun sequence Length = 4743 exon 1 AACN010210799.1 Canis familiaris ctg19866850387809, whole genome shotgun sequence Length = 1889 exon 2 AACN010260817.1 Canis familiaris ctg19866850221618, whole genome shotgun sequence Length = 1663 exon 3 AACN010230693.1 Canis familiaris ctg19866850215839, whole genome shotgun sequence Length = 1804 exon 4 AACN010305079.1 Canis familiaris ctg19866850288844, whole genome shotgun sequence Length = 1496 exon 5 AACN010993726.1 Canis familiaris ctg19866851823782, whole genome shotgun sequence Length = 670 exon 7 AACN010361281.1 Canis familiaris ctg19866850505830, whole genome shotgun sequence Length = 1354 exon 8 AACN010159249.1 Canis familiaris ctg19866850643321, whole genome shotgun sequence Length = 2164 exon 9 AACN010792582.1 Canis familiaris ctg19866850882153, whole genome shotgun sequence Length = 845 exon 11 AACN010628019.1 Canis familiaris ctg19866850796282, whole genome shotgun sequence Length = 1011 exon 12 658 MEVLSFLKLEVNGPMVTVALSVVLLALLKW 747 399 YSTAAFSRLEKLGIRHPKPSPFIGNLPFFCQ 307 593 GFWESQLAYLHRVGPMKG 540 1205 YYLGRRMFIVISEPDMIKQVLVENFHNFTNRM 1300 588 SGLESKPVMDSVLFLRDKRWEEVRSVLTSAFSPEKLNEV 472 missing exon 6 169 RCYSCYTTDVVASVAFGTQVDSRRAPGDPFVKHCRRFFAYSIPRPILVLI 318 679 VSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEE 548 661 RRRDFLQLILDARHLATSLGVDSFDMVRQVFSSTDCTVGPSRPHQPRHLSQPLTDEIVG 482 481 QAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLAEVD missing exon 10 384 RFKAEAQRRQQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLQVLHQFRFEACPETQ 220 843 VPLQLDSKSALGPKNGIYIKIVSR 772 >CYP7A1 AACN010169255.1 Canis familiaris ctg19866850386156, whole genome shotgun sequence Length = 2097 exons 2,3 missing exon 1 231 QMGEPPLENGLIPYLGCALKFGANPLEFLRANQRKYGHVFTCRLMGNYVHFITNPLSYQ 407 408 KVLCHGKYLDWKKFHFTTSAK 470 1286 AFGHRSIDPSDGNTTENINKTFIKTLQGDALNSLTEAMMENLQLVMRCPLVSK 1444 1445 SKTPAWVTEGMYSFCYRVMFEAGYLTLFGKDLTGQDAQKGLILNNLDHFKEFDKIFPALV 1624 1625 AGLPIHVFKTAHHAREKLAEGLRHENLGKRDHISELVRFLNDMLSTLDDMDKAKTHL 1795 1796 AILWASQANTIPATFWSLFQMIR 1864 missing exons 4,5 >CYP7B1 AACN010047271.1 Canis familiaris ctg19866850443252, whole genome shotgun sequence Length = 3387 exon 2 AACN010540042.1 Canis familiaris ctg19866851616560, whole genome shotgun sequence Length = 1105 exon 3 partial AACN010903862.1 Canis familiaris ctg19866850946443, whole genome shotgun sequence Length = 745 exon 5 80% to 7B1 missing exon 1 PGEPPLIKGWLPYLGEALKLQKDPLGFLRTLQKQHGDTFTLFAG 1466 GKYITFILDPFQYQLIMKTHKLSFRIFSNKL Missing exons 4 and part of 3 602 ESTVLEVLRIRSFSSIIRFVQEDLTLHSETQDYCLRKGDLVALFPPAIHYDPEIFEAPE 426 missing exon 6 >CYP8A1 AACN010168096.1 Canis familiaris ctg19866851353130, whole genome shotgun sequence Length = 2105 exon 2 90% to 8A1 AACN010022579.1 Canis familiaris ctg19866850118326, whole genome shotgun sequence Length = 4089 exon 4 AACN010078951.1 Canis familiaris ctg19866851474080, whole genome shotgun sequence Length = 2895 exon 6 partial runs off end 88% to 8A1 AACN010027010.1 Canis familiaris ctg19866850251639, whole genome shotgun sequence Length = 3916 Exons 8,9 AACN011037110.1 Canis familiaris ctg19866851254717, whole genome shotgun sequence Length = 612 exon 10 partial runs off end missing exon 1 1304 RRPGEPPLDLGSIPWLGHALEFGKDAASFLTRMKKKHGDIFT 1429 missing exon 3 3424 TLLHKDLQALTDSMYANLRTVLLGDTTEAGSGWHEISLLDFSYSCLLR 3281 missing exon 5 3 LSPARLATRAHRSNWLESYLLYLEEMGVSADMQARALVLQLWATQ 137 Missing exon 7 2838 DSVLSESLRLTAAPFITREVMVDLAMPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPE 2656 1466 VFKYNRFLNSDGSEKKDFYKDGKRLKNYSMPWGAGHNQCLGKAYAISSIKQ 1314 480 SLCRFVFLVLVHLDLELINPDMEIPEFDLSRYGFGLMQPEHXXXXXXXXX 602 >CYP8B1 AACN010849796.1 Canis familiaris ctg19866851608294, whole genome shotgun sequence Length = 791 1 HEDGLFHFCYNVLFKAGYLSLFGYTKDQEQDLRQAEELFVQFRKFDRLFPRFVYSLLGPR 180 181 EWREVGRLQRLFHKALSVKRNLEKNGISRWISYMLQYLRERGVAPAMQDKFNFMMLWASQ 360 361 GNTGPTSFWALLFLLKHPEALRAVREEATQVLGEARLKARQSFDFKVSTLHHTPVLDSVM 540 541 EETLRLGAAPTLLRVVHNDHILKMASGQEYLLRSGDIVALFPYLSVHMDPDIHPEPTTFK 720 721 YDRFLNPNGSRKVDFYKAGKKIH 789 >CYP11A AACN010473930.1 Canis familiaris ctg19866850105754, whole genome shotgun sequence Length = 1181 exon 1 74% to 11A1 572 MLAKGLPLRSVLVKGCQPFLSTVWEGPGHPRVPTGDGASISTQIPRPFSEIPTPGNNGWL 393 392 NLYNFWREMGSQKIHYHQVQNFQKYGPIYR 303 AACN010981930.1 Canis familiaris ctg19866850105752, whole genome shotgun sequence Length = 682 exon 1 71% to 11A 4 QPFLSTVWEGPGHPRVPTGDGASISTQIPRPFSEIPTPGNNGWLNLYNFWREMGSQKIHY 183 184HQVQNFQKYGPIYR 225 AACN010053733.1 Canis familiaris ctg19866850408563, whole genome shotgun sequence Length = 3266 exon 2 86% to 11A1 2246 EKLGSVESVYIIDPEDVALLFKFEGPTPERFCIPPWVAYHQYHQRPVGVLLK 2401 CE121306 tigr-gss-dog-17000325911897 Dog Library Canis familiaris genomic. Length = 755 exon 3 598 KSGAWKKDRLALNQEVMAPEAIKNFIPLLDPVSQDFVKVLHRRIKQQGSGKFSGDISDDLFRFAFE 401 AACN010876926.1 Canis familiaris ctg19866851762953, whole genome shotgun sequence Length = 766 exon 5 DVILTK 119 AEIYTQNFYWELRQKRDVDNYPGILHRLLKSNKXXFEDVK 1 AACN010197444.1 Canis familiaris ctg19866850086309, whole genome shotgun sequence Length = 1947 exon 6 81% to 11A1 1789 TSMTLQWHLYEMARSLEVQEVLREEVX 1866 1869 AARRQAQGNVSTMLQLVPLLKASIKE 1946 AACN010001547.1 Canis familiaris ctg19866850644573, whole genome shotgun sequence Length = 6752 exons 7,8,9 77% to 11A1 6545 XXRLHPISVTLQRYLENDLVLRNYMIPAK TLVQVSTYAMGQDPTFFLNPSKFDPTRWLGKDKELIHFRNLGFGWGVRQC 5907 5906 VGRRIAELEMTLFLIH 5859 5427 ILENFRVEMQQLRDVGTTFNLILMPDKPIFLTFRPFNQDPPQ 5302 CYP11A1 assembled seq. 572 MLAKGLPLRSVLVKGCQPFLSTVWEGPGHPRVPTGDGASISTQIPRPFSEIPTPGNNGWL 393 392 NLYNFWREMGSQKIHYHQVQNFQKYGPIYR 303 2246 EKLGSVESVYIIDPEDVALLFKFEGPTPERFCIPPWVAYHQYHQRPVGVLLK 2401 598 KSGAWKKDRLALNQEVMAPEAIKNFIPLLDPVSQDFVKVLHRRIKQQGSGKFSGDISDDL 419 418 FRFAFE 401 (gap of 62 aa) DVILTK 119 AEIYTQNFYWELRQKRDVDNYPGILHRLLKSNKXXFEDVKXXXXXXXXXXXXX 21 1789 TSMTLQWHLYEMARSLEVQEVLREEVXAARRQAQGNVSTMLQLVPLLKASIKEXX 1946 6545 RLHPISVTLQRYLENDLVLRNYMIPAK TLVQVSTYAMGQDPTFFLNPSKFDPTRWLGKDKELIHFRNLGFGWGVRQC 5907 5906 VGRRIAELEMTLFLIH 5859 5427 ILENFRVEMQQLRDVGTTFNLILMPDKPIFLTFRPFNQDPPQ 5302 >CYP11B AACN010869183.1 Canis familiaris ctg19866850072945, whole genome shotgun sequence Length = 773 exon 1 259 MAFRAQARGWRAGPWLALSRAPALGTRAAPAPRAVLPFEAVPRCPGNKWMRVLQIWRQQG 438 439 SESLHLEMHRTFQELGPIFR 498 AACN010901744.1 Canis familiaris ctg19866851631361, whole genome shotgun sequence Length = 747 exon 3 runs off end 746 WLAYRQHRGHKCGVFLL CE135061 tigr-gss-dog-17000326523985 Dog Library Canis familiaris genomic. Length = 491 C-helix 375 NGPEWRLNRLKLNPDVLSLQAVQKYIPMVDGVARDFSQA 491 AACN010473034.1 Canis familiaris ctg19866850846079, whole genome shotgun sequence Length = 1182 mid to I-helix 1181 LALFGERLGLLGPSPSPASLHFLQALEAMLRSTAQLLYLPRGLSRWTSARVWKEHFESWD 1002 1001 YIVQYGED 978 708 AIQRIYQELALGRPQHYSGIVGELLLRADLSPEAVRANCIELTAGSVDT 562 AACN011088907.1 Canis familiaris ctg19866850219938, whole genome shotgun sequence Length = 241 J-helix to K-helix 50 TAYPLWMTLFELARNPDVQHALRQESRGAQAGIAENPQTAVTELPLLRAALKETLR 217 AACN010420800.1 Canis familiaris ctg19866850139565, whole genome shotgun sequence Length = 1252 C-term Sbjct: 195 VLNNFLVETLTHEDVKMVYRFIMMPSTLPLLTFRAIH 305 CYP11B assembled seq. 259 MAFRAQARGWRAGPWLALSRAPALGTRAAPAPRAVLPFEAVPRCPGNKWMRVLQIWRQQG 438 439 SESLHLEMHRTFQELGPIFR 498 (gap of 35 aa) 746 WLAYRQHRGHKCGVFLL 375 NGPEWRLNRLKLNPDVLSLQAVQKYIPMVDGVARDFSQA 491 (gap of 30 aa) 1181 LALFGERLGLLGPSPSPASLHFLQALEAMLRSTAQLLYLPRGLSRWTSARVWKEHFESWDYIVQYGED 978 708 AIQRIYQELALGRPQHYSGIVGELLLRADLSPEAVRANCIELTAGSVDT 562 TAYPLWMTLFELARNPDVQHALRQESRGAQAGIAENPQTAVTELPLLRAALKETLR 217 (gap of 92 aa) 195 VLNNFLVETLTHEDVKMVYRFIMMPSTLPLLTFRAIH 305 >CYP17A1 BM536554 ha71f04.g2 Canis cDNAs from testes cells Canis familiaris cDNA BM537848 ha87c11.g1 Canis cDNAs from testes cells Canis familiaris cDNA AACN010944904.1 Canis familiaris ctg19866851677953, whole genome shotgun sequence Length = 714 BM539980 hb16e12.g1 Canis cDNAs from testes cells Canis familiaris cDNA AACN010353889.1 Canis familiaris ctg19866851381804, whole genome shotgun sequence Length = 1370 35 MWELLVFLLFTLVYFLWPKSKCPNAKYPRSLPSLPLVGSLPFLPRDGHQHVSFFKLQKKY 214 215 GPIYSFRMGTKTTVMVGHHQLAKEVLIKKGKEFSGRPRVVTMDILSDNQKGIAFADHGAS 394 395 WQLHRKLALATFALFKDGNQRLEKI 94 VCQENSLLCDFLATQNGKSIDLSLPLFLAVTNIICLICFNTSYKNGDPALEIIKNYNDGI 273 274 LDTLGRDHMIDIFPGLK 324 169 IFPNKTLEKMRNCVKMRDDLLNEILEKYKQEKFSSDSITNMLDILIQARMNSDDNNAGSD 348 349 RDSKLLSDKHILISIGDIFGAGVETTTSVVKWTVAFLLHNPQLQKKIQEEIDQNVGFGRIPTMS 540 2 DRSKLILLEATIREVLRIRPAAPMLIPHKAIVDS 103 640 SIGEFAVDKGTSVIINLWALHHNEKEWYRPDQFMP 744 1249 ERFLDATKSQLISPSLSYLPFGAGPRSCVGEILARQELFL 1368 missing C-term >CYP19A1 AACN010852794.1 Canis familiaris ctg19866851319222, whole genome shotgun sequence Length = 788 AACN010407010.1 Canis familiaris ctg19866850244415, whole genome shotgun sequence Length = 1272 AACN010485402.1 Canis familiaris ctg19866851105922, whole genome shotgun sequence Length = 1167 AACN010929795.1 Canis familiaris ctg19866850736587, whole genome shotgun sequence Length = 725 AACN010393942.1 Canis familiaris ctg19866850216163, whole genome shotgun sequence Length = 1293 AACN010542530.1 Canis familiaris ctg19866851190705, whole genome shotgun sequence Length = 1102 missing N-term 35 aa 780 LLVWNYEDTSSIP 742 1100 GPGYCMGIGPLISHCRFLWMGIGSACNYYNKMYGEFMRVWICGGEETLIISK 1253 (51 aa gap) 1023 ALSGPGLVRMVTVCVGSIITHLDRLEEVSNELGYX 1124 1130 DVLTLMRRIMLD 1165 (12 aa gap) 713 ESAIVVKIQGYFDAWQALLLKPDIFFKISWLYKKYEKSV 597 520 KDLKDAMEILIEEKRHRISTAEKLEDHMDFATELIFAE 1069 KRGDLTRENVNQCILEMLIAAPDTMSVSVFFMLFLIAKHPKVEESIMKEIQAVVG 1233 (55 aa gap) 1102 NIGRMHRLEFFPK 1064 PNEFTLENFAKNV 1024 missing 81 aa at C-term >CYP20A1 AACN010269590.1 Canis familiaris ctg19866850856128, whole genome shotgun sequence Length = 1625 exon 1 AACN010533299.1 Canis familiaris ctg19866850930306, whole genome shotgun sequence Length = 1112 aa 41-96 exon 3, only 1 aa diff to human AACN010277385.1 Canis familiaris ctg19866850441051, whole genome shotgun sequence Length = 1593 exon 4 AACN010655492.1 Canis familiaris ctg19866851620696, whole genome shotgun sequence Length = 983 exon 6 AACN010250179.1 Canis familiaris ctg19866850048729, whole genome shotgun sequence Length = 1713 exon 8 AACN010152085.1 Canis familiaris ctg19866850668592, whole genome shotgun sequence Length = 2215 exon 9 AACN010295104.1 Canis familiaris ctg19866850994966, whole genome shotgun sequence Length = 1529 exon 10 AACN010226278.1 Canis familiaris ctg19866850927366, whole genome shotgun sequence Length = 1824 exon 11 AACN010759102.1 Canis familiaris ctg19866851085782, whole genome shotgun sequence Length = 878 exon 13 partial runs off end 323 MLDFAIFAVTFLLALVAAVLYLYP 394 missing exon 2 927 DGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVEVLKQHINPNKT 1091 903 ADPFETMLKSLLRYQSGGANVSENHMRKKLYESGVTHSLQSNFALLLK 760 missing exon 5 413 VWSEIGKGFLDGSLDKSTTRKKQYED 336 missing exon 7 319 ILEDSMIFSLASCIITAK 372 VCTWAICFLTTSEEVQKKLYEEIDHVFGKDPITPEKIEQLR 323 503 YCRHVLCETVRTAKLTPVSARLQDIEGKIDKFIIPRE 613 1557 TLVLYALGVILQDPRTWPSPHK 1492 missing exon 12 876 XXXXXXXXLLSVLVRRLHLLSVEGQLIETKYELVTSSKEETWITVSKRY 754 >CYP21A dog GenEMBL AB039881 Takada,K., Kitamura,H., Kanehira,K., Takiguti,M. and Hashimoto,A. Canine P450c21(21-hydroxylase) mRNA Published Only in DataBase (2000) MLLLGVLLLTVLAGARLLWGKWKLRGLHLPPLVPGCLHLLQPDL PLHLLGLTQKLGPIYRLRLGLQDVEVLNSKRTIEEAMVRKWVDFAGRPQTPSYKLVSL HHQDLSLGDYSLLWKAHKKLTRSALLLGIRSSMEPLVEQLTQEFCERMRAQAGTPVAI QKEFSLLTCAIICHLTFGNKEDTLVHTFHDCVQDLMRTWEHWSIQMLDIIPFLRFFPN PGLWRLKRALENRDHIVEKQLRQHKESMVAGQWRDMTDYMLQRVGRLRAEEGCGQLLE GHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQQRLQEELDRELGPGASGSRIPY RDPTRLPLLSATVAEVLRLRPVVPLALPHCTTRPNSISGYDIPEGMVVIPNLQGAHLD ETVWERPQEFRPDRFLVPGASPRVLAFGCGARVCLGEPLARLELLVVLAQLLRAFTLM PAAGTLPSLRPRARCGVNLSMQPFQVQLQPRGAGVLGRGQHP >CYP21A AACN010174454.1 Canis familiaris ctg19866851154053, whole genome shotgun sequence Length = 2066 exon 5 81% to 21A2 1188 VVDLFIGGTETTATTLSWAVAFLLHHPEVR 1099 >CYP24 AACN010189575.1 Canis familiaris ctg19866850397039, whole genome shotgun sequence Length = 1984 AACN010475988.1 Canis familiaris ctg19866850286932, whole genome shotgun sequence Length = 1178 AACN010015736.1 Canis familiaris ctg19866850380953, whole genome shotgun sequence Length = 4443 AACN010128919.1 Canis familiaris ctg19866850387233, whole genome shotgun sequence Length = 2398 AACN010244558.1 Canis familiaris ctg19866850352610, whole genome shotgun sequence Length = 1740 missing N-term 141 aa 1376 EGEDWQRVRSAFQKKLMKPVEIMKLDNKINE 1284 626 VLADFMGRIDELCDERGRIEDLYSELNKWSFES 528 1671 ICLVLYEKRFGLLRKNAGDEALNFIMAIKT 1760 2410 MMSTFGRMMVTPVELHKSLNTKVWQAHTLAWDTIFKS 2520 3961 VKSCIDNRLEKYSEQPSTDFLCDIYHHNQLSKKELYAAVTELQLAAVET 4107 1269 TANSLMWILYNLSRNPHVQQKLLKEIQRVLPENQMPRAEDLRNMPYLKACLKESMR 1436 159 LTPSVPFTTRTLDKETVLGEYALPKG 716 TVLMLNTQVLGSNEENFKDSSQFRPERWLQEKKKINPFAHLPFGIGKRMCIGRRLAELQLHLALCW 913 1008 IIRKYDIVATDHEPVEMLHLGILVPSRELPIAFRQR 1115 >CYP26A1 AACN010319956.1 Canis familiaris ctg19866850653805, whole genome shotgun sequence Length = 1453 AACN010331905.1 Canis familiaris ctg19866850206901, whole genome shotgun sequence Length = 1421 AACN010830399.1 Canis familiaris ctg19866851673669, whole genome shotgun sequence Length = 809 CE328062 tigr-gss-dog-17000333951331 Dog Library Canis familiaris genomic Length = 667 993 MGLSALLASALCTFVLPLLLFLAAIKLWDLYCVSSRDRSCALPLPPGTMGFPFFGETLQMVLQ RRKFLQMKRRKYGFIYKTHLFGRPTVRVM 1451 (seq gap missing exon ) 35 VIMRAFSREALQCYVPVIAEEVGTCLQQWLSRGERGLLVYPQVKRLMFRISMRILLGCE 211 212 PRLASGGDAEQQLVEAFEEMTRNLFSLPIDVPFSGLYR GMKARNLIHARIEENIRAKICGLRTAQAGGGCKDALQLLIEHSWERGERLDMQ 571 1083 ALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSK 1217 589 GLLCKSNQDNKLDIEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELN 437 156 GYQIPKGWNVIYSICDTHDVADIFTNKDEFNPDRFMLPHPEDASRFSFIPFG 1 631 GGLRSCVGKEFAKILLKIFTVELARHCDWRLLNGPPTMKTSPTVYPVDDLPARFTHFQGEI 449 >CYP26B1 CE132262 tigr-gss-dog-17000326234445 Dog Library Canis familiaris genomic. Length = 281 exon 1 AACN010822105.1 Canis familiaris ctg19866851851860, whole genome shotgun sequence Length = 816 exon 2 AACN010387783.1 Canis familiaris ctg19866850946138, whole genome shotgun sequence Length = 1304 exon 3 partial runs off end AACN010774717.1 Canis familiaris ctg19866851668727, whole genome shotgun sequence Length = 863 exon 4 runs off end AACN010983002.1 Canis familiaris ctg19866851162065, whole genome shotgun sequence Length = 681 exon 5 partial runs off end AACN010204642.1 Canis familiaris ctg19866850811020, whole genome shotgun sequence Length = 1916 exon 6 188 MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIG 9 8 ETXXXXXX 3 715 GSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRML 548 547 LGPNTVANSIGDIHRNKRK 491 218 VFSKIFSHEALQSYLPKIRLVIQDTLRAWSSHPEAINVYQETQKLTFRMAIRVLLGFSI 42 42 PEEDLGHLFEVYQQ 1 (seq gap of 23 aa) 863 RQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELK 720 139 DGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGILHSGGCPCEGTLRLDT 318 319 LSRLHYLDCVIKEVMRLFTPISGGYRTVLQTFELDXXXXXXX 423 2 WSVMYSIRDTHDTAPVFKDVNVFDPDRFGQARSEDKDGRFHYLPFGGGVRTCLGKHLAKL 181 182 FLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPETEAMLSATV 370 >CYP26C1 CE357229 tigr-gss-dog-17000361410394 Dog Library Canis familiaris genomic. Length = 173 N-term GSS frag exon 1 partial AACN010825609.1 Canis familiaris ctg19866850788373, whole genome shotgun sequence Length = 813 this exon 2 part is 100% identical to human AACN010891180.1 Canis familiaris ctg19866851156114, whole genome shotgun sequence Length = 755 AACN010333576.1 Canis familiaris ctg19866850531516, whole genome shotgun sequence Length = 1417 111 MFPWGPSCLSVLGAAGTALLCAGLLLSLAQHLWTLRW 1 (gap of 31 aa) 726 GSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGS 550 549 HTLLGAVGEPHRRRRK 502 missing exon 3 (gap of 22 aa at start of exon 4) 753 DKVAEPGDALDMIIHSTRELGHELSVQELK 664 1172 ETAVELLFAAFLTTASASTSLVLLLLQHPAAVAKIRQELAAQGLGRACGCAPGAAGGGAG 1417 missing part of exon 5 and exon 6 >CYP27A1 CE447392 tigr-gss-dog-17000319055344 Dog Library Canis familiaris genomic. Length = 640 AACN010936951.1 Canis familiaris ctg19866851630101, whole genome shotgun sequence Length = 720 AACN010845392.1 Canis familiaris ctg19866851643298, whole genome shotgun sequence Length = 795 AACN010438403.1 Canis familiaris ctg19866851146379, whole genome shotgun sequence Length = 1227 missing N-term 85 aa 416 VLNKAKYGPMWVTHAGPQTHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQQGLAYGPFTT 607 568 SEGHHWYQLRHALNQRMLKPSEAALYTDALNEVVDDFMAHLSQLLAESPSGNQVSDMAHQFYYFALE 368 239 AICYILFEKRIGCLERPIPQDTVAFVRSVGLMFQNSVYVTFLPKWTRPLLPFWKRYLDGWNTIFSFG 39 missing exon 212 TSNTMTWALYHLSKNPEIQAALHKEVVGVVPPGQVPQQKDFAHMPLLKAVLKETLR 379 537 LYPVVPINSRVITEKEIEVNGFLFPKN 617 698 TQFVFCHYVVSRDPDIFPEPESFQPYR 778 missing exon 140 LIQQYQVVLAPETGEVKSLARIVLVPNKKVSLHFQPRQC 256 >CYP27B1 AACN010968095.1 Canis familiaris ctg19866851723056, whole genome shotgun sequence Length = 695 AACN010905536.1 Canis familiaris ctg19866851406795, whole genome shotgun sequence Length = 744 AACN010092086.1 Canis familiaris ctg19866851894583, whole genome shotgun sequence Length = 2745 missing N-term 65 aa 201 VQGVARFGPVWLASFGKVRTVYVAAPALVEQLLRQEGPRPERCSFSPWAEHRRHRQRACGLLTA 10 (gap of 106 aa) 20 LAMPGWLHRLVPGPWGRLCRDWDQMFAF 188 AQQHVERREAEVALRSEGKAAEDVGSGAHLTYFLLREELPAPSILGNVTELLLAGVDT 361 565 VSNTLSWALYELARHPDVQTALHSEITAALGPGSSAHPSAAALSQLPLLKAVVKEVLR 738 (gap of 26 aa) 379 TLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPAPHPFASLPFGFGKRSCMGRRLAELELQMALAQ 576 893 ILTHFEVQPEPGAAPIRPMTRTVLVPERSINLQFVDR 1003 >CYP27C1 AACN010667637.1 Canis familiaris ctg19866850827949, whole genome shotgun sequence Length = 970 exon 3 AACN010393088.1 Canis familiaris ctg19866851009116, whole genome shotgun sequence Length = 1295 exon 4 AACN011051454.1 Canis familiaris ctg19866850281851, whole genome shotgun sequence Length = 580 exon 5 AACN010724666.1 Canis familiaris ctg19866850281849, whole genome shotgun sequence Length = 912 exon 5 duplicate 735 GVATILYESRLGCLENSVPQPTVDYIEALGLMFSMFKTSMYAGAIPRWLRPLIPKPWLE 911 AACN010239150.1 Canis familiaris ctg19866850441995, whole genome shotgun sequence Length = 1765 exon 7 AACN010505917.1 Canis familiaris ctg19866850894052, whole genome shotgun sequence Length = 1143 exon 9 AACN010867864.1 Canis familiaris ctg19866850032681, whole genome shotgun sequence Length = 774 exon 10 missing exons 1,2 643 QKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGATPQRANMESWQEYRHLRGRSTGLISA 834 459 EGEQWLKMRRVLRQRILKPRDVAIFSGEINQVIADLIKRIYILKSQAEDGETVTNVNDLFFKYSME 656 174 GVATILYESRLGCLENSVPQPTVDYIEALGLMFSMFKTSMYAGAIPRWLRPLIPKPWLEFCRSWDGLFKFS 386 missing exon 6 1363 TSFTLSWAVYLLARHPQVQQTLYQEIVKNLGERHIPTAADVPKVPLVRALLKETLR 1196 missing exon 8 141 TQLALCHYATSYEDENFPRAKEFWPERWLRKGSLDRVDNFGSIPFGYGVRSCIGRRIAELEIHLAIIQ 344 592 LLQHFEIKPSSWTKAVPAKTHGLLTPGGPIHVRFVNRK 479 >CYP39A1 AACN010725049.1 Canis familiaris ctg19866851012872, whole genome shotgun sequence Length = 912 exon 1 AACN010017119.1 Canis familiaris ctg19866850153718, whole genome shotgun sequence Length = 4361 exon 2 AACN010076390.1 Canis familiaris ctg19866850297002, whole genome shotgun sequence Length = 2926 exons 3, 4 AACN010076390.1 Canis familiaris ctg19866850297002, whole genome shotgun sequence Length = 2926 part of exon 5, runs off end AACN010416264.1 Canis familiaris ctg19866850323147, whole genome shotgun sequence Length = 1258 exon 6 AACN010931414.1 Canis familiaris ctg19866851210864, whole genome shotgun sequence Length = 724 exon 7 with frameshifts AACN010027413.1 Canis familiaris ctg19866851229644, whole genome shotgun sequence Length = 3903 exon 8 AACN010629095.1 Canis familiaris ctg19866851048907, whole genome shotgun sequence Length = 1010 exon 9 AACN010254090.1 Canis familiaris ctg19866850234662, whole genome shotgun sequence Length = 1694 exon 10 CE517620 tigr-gss-dog-17000327422880 Dog Library Canis familiaris genomic. Length = 592 exon 11 80% to human CYP39A1 4 MELISPTVIIILGCVALLLFLQRKNLRGPPCIRGWIPWIGAGFEFGKAPLEFIEKARIK 180 4003 YGPIFTVFVMGNRMTFVTEEEGINVFLKSKEVNFELAVQNPVYRT 4137 278 ASIPKNTFLALHEKLYIMMKGKIGTFNLYQFTGQLTEELHEQLENLGTHGTMELNHLVR 454 1781 NLLYPVTMNMLFKKGLFPRNEGKIREFYQHFQAYDEGFEYGSQMPECLLR 1930 2872 NWSKSKKWLLALFRKXXXXXXXXXXXXXXXX 2916 316 TLMQTMLDIVEMERKEEKSPNYGLLLLWASLSNAVP 423 619 VAFWTLAFVLSHPSIHKTIXEGVSSVLGTAG 3061 KDKMKVSEDDLKKLPLIKWCILEAIRLRAPGIITRKVLKPVKIL 3192 308 NYTVPSGDLLMLSPFWLHRNPEYFPEPELFKP 213 1058 ERWKKANLEKHAFLDWFMAFGSGKYQCPGR 960 WFALLEIQICIILILYKYDCSLLDPLPKQ 210 missing exon 12 >CYP46 AACN011063676.1 Canis familiaris ctg19866851031270, whole genome shotgun sequence Length = 539 exon 1 AACN010121970.1 Canis familiaris ctg19866851248644, whole genome shotgun sequence Length = 2458 exon 3 AACN010912139.1 Canis familiaris ctg19866851522000, whole genome shotgun sequence Length = 739 exon 4 AACN010126951.1 Canis familiaris ctg19866850087798, whole genome shotgun sequence Length = 2415 part of exon 5 AACN010126951.1 Canis familiaris ctg19866850087798, whole genome shotgun sequence Length = 2415 exon 6 AACN011043035.1 Canis familiaris ctg19866850938349, whole genome shotgun sequence Length = 600 exons 7, 8 AACN010078512.1 Canis familiaris ctg19866850924620, whole genome shotgun sequence Length = 2900 exon 9 AACN010562079.1 Canis familiaris ctg19866850995919, whole genome shotgun sequence Length = 1081 exons 10, 11 AACN010487676.1 Canis familiaris ctg19866850532063, whole genome shotgun sequence Length = 1164 exons 12, 13 BI395391 CYP46 EST part of exon 9, exons 11-13, part of exon 14 BQ234100 CYP46 EST for C-term 473 MSPGLLLLLGSAVLVAFGLCCTFVHRARSRYEHIPGPPRP 354 missing exon 2 1987 AKKYGPVVRVNVFHKTSVIVTSPESVK 1907 117 KFLMSTKYNKDSKMYHAIQTVFGER 191 missing C-helix part of exon 5, This exon may be split in dog 1935 SSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCTTMDILAK 1795 1054 AAFGMETGMLLGAQKPLSRKVKLILEGITASRNTLAK 944 23 XXXGKWKQLREIRESIRFLRQVGKDWVQRRREALKRGEDVPADILTQILK 169 378 AEEGAQDDEILLDNFVTFFIAG 443 1121 HETSANHLAFTVMELSRQPEILAR 1192 370 LQAEVDEVIGSKRHLDCDDLGRLQYLSQ 453 968 VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL 1078 962 FSTYVMGRMDTYFEDPLTFNPDRFSPKAPK 873 159 PRFTYFPFSLGPRSCIGQQFAQ 94 MEVKVVMAKLLQRLEFRLVPGQRYGLQEQATLKPLDPVLCTLQPRGWQPAPPPPC 312 >CYP51A1 BM539179 EST covers N-term AACN011071482.1 Canis familiaris ctg19866850325674, whole genome shotgun sequence Length = 499 exon 1, partial runs off end AACN010137865.1 Canis familiaris ctg19866850944358, whole genome shotgun sequence Length = 2325 exon 2 AACN010525666.1 Canis familiaris ctg19866851778774, whole genome shotgun sequence Length = 1120 exon 3 AACN010201865.1 Canis familiaris ctg19866850772619, whole genome shotgun sequence Length = 1928 exon 4 AACN010239142.1 Canis familiaris ctg19866850411235, whole genome shotgun sequence Length = 1765 exon 5 AACN010197522.1 Canis familiaris ctg19866851347944, whole genome shotgun sequence Length = 1947 exons 6, 7 CF411979 = EST of C-term 497 MLLLGLLQAGGSVLGQAMERVTGGNLLSMLLIACAFTLGLVYLIRLAVGHLAPLPAGA 333 747 KSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEK 845 828 YGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNP 649 265 VFLEQKKMLKSGLNIAHFRQHVSIIEKETKEYFQSWGESGEKS 393 1089 DLFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSF 916 365 RRRDRAHREIKNIFYKAIQKRRQSEEKIDDILQTLLDSTYK 487 902 DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQDKCYLEQKTVCGEDLPPLTYDQ 1096 LKDLNLLDRCIKETLRLRPPIMTMMRM 567 566 AKTPQTIAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFG 387 386 AGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK 207 >CYP51 pseudogene most like CYP51P2 AACN010874668.1 Canis familiaris ctg19866851875661, whole genome shotgun sequence Length = 768 KSPPYIFSPVPFLEHGLA FGRSPAECL*NTCEEHGHVFSFTVVGKTCTYLLGSDACCCTAFLKSTDEDQNA 219 220 KEVYSHLTILVFGKRIACDVPNPVFMKQKKI MRSGLNIXXXXXXXXXXXXX KEYFQSWGEXXX 397 KN*LEAPSELVIFTASHYSYRKEIRS*LHKKVAQLCVHLGGGFNSAICLFPVGLP 561 LPSFRXX 575 DRAHQEIKNIFCKAIQKHRLKNKIDYIL*TLLDSTHK 685 IGCPLADDEVAGKPFGLFLAGQPTSS 764