ࡱ> 9;678 bjbjв 4*к_к_`````tttt|t$&&&&&&$I~J`J``_.``$$P:MiPu0`(JJX &: This alignment contains 122 sequences and is 746 characters long Numbers after CYP names refer to Fugu Scaffold numbers There are 60 human 54 Fugu and 8 other fish sequences included. 2C9 -------------------------MDS------------ 2C19 -------------------------MDP------------ 2C18 -------------------------MVP------------ 2C8 -------------------------MEP------------ 2E1 -------------------------MFALGV--------- 2F1 -------------------------MDSI----------- 2W1 -------------------------MALL----------- 2B6 -------------------------MELS----------- 2A6 -------------------------MLASGML-------- 2A7 -------------------------MLASGLL-------- 2A13 -------------------------MLASGLL-------- 2G1P -------------------------MELGGAV-------- 2G2P -------------------------MEMGGAV-------- 2M1 trout-------------------------MDVLHILQTN----- 2J2 -----------------------MLAAMGSLAAALWAVVH 2X2 4007-------------------------MV------------- 2X3 -------------------------ML------------- 2X1catfish-------------------------ML------------- 2V1 Danio---------------------MALENILLHLNSKVWTDAG 2Z2 2993b-------------------------MHWIFDLIGSFLAGD 2P3 killi-------------------------MEAIRSVLGLEWID- 2P4 -------------------------MEAILSTLGLEWMD- 2N2 killi-------------------------MWFYNLLLSLD---- 2N11 3261c-------------------------MWPLQLLLDFD---- 2N10 3261b-------------------------MWLYSVLSWD----- 2N12 3261d-------------------------MILQKIFAYMD---- 2N9 3261a-------------------------MWLWDLVLWLRL--- 2Y2 39b -------------------------ME------------- 2R1 7138 --------------------MVPAQSPPLVPPSRDQALLG 2U1 8899 -------------------------MMSLSWLQSLSSS-- 2U1 -------MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPS 2Z1 2993a-------------------------MGLIVSVFGSHADWS 2K9 12487-------------------------MIEDLFESSTSG--- 2K6 Danio------------------------MALIEAFLLQGSPTGA 2Y1 39a -------------------------MDLT----------- 2K10 19693-------------------------MSLQDFLLSLGPS-- 2K11 ----------------------MGIVDLFLQASSSVSLLL 2R1 -------------------------MWKLWRAEEGAAA-- 2S1 -------------------------MEATGT--------- 2T2P ---------------------------------------- 2D6 ----------------------------MGLEALV----- 1A1 ----------------------MLFPISMSATEFL----- 1A2 --------------------MALSQSVPFSATELL----- 1B1 -----------MGTSLSPNDPWPLNPLSIQQTTLL----- 1B3 3008a-----------MG-DFGLKSSSITREWSGHV--------- 1B2 3008b---------MALDTEFGVKSSSITREWSGQV--------- 1B1 1553 -----------MKVIQEEVSPE------------------ 17 ---------------------------------------- 17A1 4175 -------------------------MDWV----------- 17A2 8086 ---------------------------------------- 21 ---------------------------------------- 21 15 -------------------------MCSFLFCSS------ 3A4 -------------------------MAVIPDLAME----- 3A5 -------------------------MDLIPNLAVE----- 3A7 -------------------------MDLIPNLAVE----- 3A43 -------------------------MDLIPNFAME----- 3A47 600 -------------------------MNYLPLFALE----- 3B1 2213a-------------------------MFEFVLFSGT----- 3B2 2213b-------------------------MFVFMCFSAT----- 3A48 -------------------------MDLLPNFSIE----- 3A49 ---------------------------------------- 3A50P -------------------------MNFLPDFFLN----- 3A27 trout-------------------------MMSFLPYFSAE---- 5A1 -------------------MEALGFLKLEVNGPMV----- 5A1 1244 -------------------MSQLIFNIKFLE--------- 4A11 -------------------------MSVSVLSPSRLLGD- 4A22 -------------------------MSVSVLSPSRRLGG- 4A20 -------------------------MEPSWLQEL------ 4B1 -------------------------MVPSFLSLS------ 4F2 -----------------------MSQLSLSWLGLCDVAAS 4F3 -----------------------MPQLSLSSLGLWPMAAS 4F8 -----------------------MSLLSLSWLGLRPVAAS 4F11 -----------------------MPQLSLSWLGLGPVAAS 4F12 -----------------------MSLLSLPWLGLRPVAMS 4F22 ---------------------MLPITDRLLHLLGLEKTAF 4F28 2425 -------------------------MSVLQLALS------ 4X1 -------------------------MEFSWLETRWAR--- 4V2 -------------------------MAGLWLGLVWQK--- 4V5 485 -------------------------MADLL---------- 4T5 8637 -------------------------MEITRALVV------ 4T2seabass-------------------------MELTEAFLTLH---- 46 ---------------------------------------- 46 4537 -------------------------MGVFNLIFGW----- 20 ---------------------------------------- 20 486 ---------------------------------------- 26A1 -------------------------MGLPALLA------- 26A1 12575-------------------------MAVSALLA------- 26B1 4267 --------------------MLFDSFDLVSALA------- 26C1 11741------------------------MLGLVSALA------- 26B1 -------------------------MLFEGLDLVSA---- 26C1 -------------------------MFPWGLSCLSV---- 11A1 --------------------------MLAKGLPPRSVLVK 11A1 1630 --------------------------MARWSVWRSPVVLP 11B1 --------------------------MALRA--------- 11B2 --------------------------MALRA--------- 11B1 fugu ----------------------MWLPAGAGVRARSARGFR 27A1 ---------------MAALGCARLRWAL---RGAGRGLCP 27A1 FUGU ---------------MSACLCVNSCGRK---EAGCCGLWP 27A2 697 --------------------------MASFTALR------ 27A3 ----------------------MFRNRLLTVGLRASVPHR 27B1 --------------------------MT------------ 27B1 470 --------------------------MLQQALRV------ 27C1 ----MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQ 27C1 1410 --------MSVMNKLTTTCWTNFYGDRRNKQMLFVLRCLH 24 ---------------MSSPISKSRSLAAFLQQLRSPRQPP 24 1804 ---------------------------------------- 19 --------------------------MVLE---------- 19ov 7098 --------------------------MAAVGLDAEVLV-- 19br 4200 --------------------------MKPKE--------- 8A1 -------------------------MAW------------ 8A2 5061 ---------------------------------------- 8A1 4451 ---------------------------------------- 8B1 -------------------------MVLWGP--------- 8B1 7782 -------------------------MASVLL--------- 8B2 21917-------------------------MASLLL--------- 7B1 ------------------------MAGEVSAATGRFSLER 7A1 --------------------------MMTTSLI---WGIA 7A1 5172 --------------------------MILSIA--LIWAVV 7C1 16085---------------------------------------- 39A1 --------------------------MELISPT---VIII 51 -------------MAAAAGMLLLGLLQAG-GSVLGQ---- 51 437 -------------MSAHLYEMSSKL--------------- 2C9 ---LVV-LVLCLSCLL--L-LSLWR-------------QSSGRGKLPPGPTPL-PVIGNI--LQIGIKDI 2C19 ---FVV-LVLCLSCLL--L-LSIWR-------------QSSGRGKLPPGPTPL-PVIGNI--LQIDIKDV 2C18 ---AVA-LVLCLSCLF--L-LSLWR-------------QSSGRGRLPSGPTPL-PIIGNI--LQLDVKDM 2C8 ---FVV-LVLCLSFML--L-FSLWR-------------QSCRRRKLPPGPTPL-PIIGNM--LQIDVKDI 2E1 ---TVA-LLVWAAFLL--L-VSMWR-------------QVHSSWNLPPGPFPL-PIIGNL--FQLELKNI 2F1 ---STA-ILLLLLALV--C-LLLTL-------------SSRDKGKLPPGPRPL-SILGNL--LLLCSQDM 2W1 ---LLL-FLGLLGLWG--L-LCACA------------QDPSPAARWAPGLRPL-PLVGNL--HLLRLSQQ 2B6 ---VLL-FLALLTGLL--L-LLVQR-------------HPNTHDRLPPGPRPL-PLLGNL--LQMDRRGL 2A6 ---LVA-LLVCLTVMV--L-MSVWQ-------------QRKSKGKLPPGPTPL-PFIGNY--LQLNTEQM 2A7 ---LVA-LLACLTVMV--L-MSVWQ-------------QRKSKGKLPPGPTPL-PFIGNY--LQLNTEHI 2A13 ---LVT-LLACLTVMV--L-MSVWR-------------QRKSRGKLPPGPTPL-PFIGNY--LQLNTEQM 2G1P ---TIF-LALRLSCLL--I-LIAWK-------------RMDKAGKLPPGPTPI-LFLGHL--LQVRTDAT 2G2P ---TIF-LALCLSCLL--I-LIAWK-------------*MNKAGKLPPGPTPI-PFLGNL--LQVRTDAT 2M1 trout---FVS-IIIGFVVII--L-LWMNR-------------GKQSNSRLPPGPAPI-PLLGNL--LRMDVKAP 2J2 ---PRT-LLLGTVAFL--L-AADFL-------------KRRRPKNYPPGPWRL-PFLGNF--FLVDFEQS 2X2 4007---TSV-ILLCLGVVV--L-VL-LL-------------RSQRPKNFPPGPPVL-PLLGSI--LELALDNP 2X3 ---VSL-ALLLAAAFG--L-WV-FF-------------QIQRPKNFPPGPPPI-PLFGNL--LEIQLDNP 2X1catfish---GSW-LLVVFCVCL--L-FL-FI-------------RIQRPKNFPPGPRPI-PIFGNL--FQFNIKNP 2V1 Danio---TIL-LLFILFLLV--S-VKLRN-------------RNKPTKTFLLGPTPL-PFIGNV--FNLDTSQP 2Z2 2993b---FKS-LLFFLLIFI--L-TADYL-------------RNRRSGSFPPGPMAI-PIIGNM--LSLDRSRT 2P3 killi---ARG-VLLFFFVFL--L-LSDVL-------------RNRKPKNFPPGPLAL-PFIRDL--HRIRPARL 2P4 ---GRT-ILIFLLVFV--L-LADYI-------------KNRVPSNFPPGPWPL-PLIGDL--HRINPSRL 2N2 killi---VKG-LFLFIFLFL--L-IADFY-------------KSRKPANFPPGPKAL-PFVGNF--FSLDSKHP 2N11 3261c---IRA-LLLFISVLL--L-IGDYF-------------RYKNPPNFPPGPMSL-PFVGSF--FSVDSKHP 2N10 3261b---FTS-LLLFFFVLI--L-FANYL-------------KNRDPPNFPPGPFAF-PIVGNF--FTMDSKNL 2N12 3261d---FSS-WVLLIFLVL--L-ITDVI-------------RNWTPHNFPPGPWAM-PFVGNI--FTGVD--- 2N9 3261a---TGF-LLPVLIVLL--I-IMYSL-------------RQKDPPNFPPGPPAL-PLLGNI--FNIEAKQP 2Y2 39b ---FSV-TLILAGLVL--A-FFWFI-------------LQKRKYNLPPGPTTL-PLVGNL--PQLDKKQP 2R1 7138 ---LAC-LTVAFLAVL--L-VRQLV-------------KQRRPPGFPPGPSPI-PIIGNI--MSLAT-EP 2U1 8899 ---ILT-LVIMIILHH--L-FKCYQ-------------KRHGFANIPPGPKPW-PVVGNF---GGFL-NA 2U1 ---GGA-LLLCGLVAL--L-GWSWL-------------RRRRARGIPPGPTPW-PLVGNF---GHVLLPP 2Z1 2993a---IST-LLLFTAVFI--L-MVNWI-------------RNRRPPSFPPGPWTL-PVVGNM--HNLAHHRM 2K9 12487---FLM-VAIVSLLLL--Q-LCFSF-------------ISREKRKDLPGPEAL-PLLGNL--HQLDLKRL 2K6 Danio---ILG-ALLLFLVIY--L-FSSSS-------------SSQDKEKYPPGPKPL-PLLGNL--HILDLKKT 2Y1 39a ---VML-LTATLLLVV--L-WILNA-------------HTRKHTRLPPGPRGI-PVLGNL--LQLDKKAP 2K10 19693---TLM-GSVALLLLL--C-LVSRS-------------FGRATRREPPGPRAL-PLLGNL--LQLDLSRP 2K11 ---LGA-LALLLFVYF--I-SSVSF-------------SSKKDRKCPPGPKPL-PILGNL--LQFDLKRP 2R1 ---LGG-ALFLLLFAL--G-VRQLL-------------KQRRPMGFPPGPPGL-PFIGNI--YSLAASSE 2S1 ---WAL-LLALALLLL--L-TLALS-------------GTRARGHLPPGPTPL-PLLGNL--LQLRPGAL 2T2P --------------------------------------RAQMRGSLPPRPRPL-PLLGNL---QLQSGGL 2D6 ---PLA-VIVAIFLLL--V-DLMHR-------------RQRWAARYPPGPLPL-PGLGNL--LHVDFQNT 1A1 ---LAS-VIFCLVFWV--I-RASRP-------------QVPKGLKNPPGPWGW-PLIGHM--LTLG-KNP 1A2 ---LAS-AIFCLVFWV--L-KGLRP-------------RVPKGLKSPPEPWGW-PLLGHV--LTLG-KNP 1B1 ---LLL-SVLATVHVG--Q-RLLRQ-------------RRRQLRSAPPGPFAW-PLIGNA--AAVG-QAA 1B2 3008a---QPA-LVAFFVFLF--C-VEACL-------------WAKNLKRRLPGPFAW-PVVGNA--MQLG-QMP 1B3 3008b---QPA-LVASFLFLF--C-LEACL-------------WVRNLKRRLPGPFAW-PVVGNA--MQLG-QMP 1B1 1553 ---AGA-LLLACATLLV-S-LQLWR-------------WRRRRPGCPPGPRAW-PIIGNA--AQLG-HAP 17 --MWEL-VALLLLTLA--Y-LFWPK-------------RRCPGAKYPKSLLSL-PLVGSL-PFLPRHGHM 17A1 4175 LFVYAF-SAVNLALLA--L-HLKFR-------------TPASGPRGPPRLPAL-PLIGSL-LSLRSPHPP 17A2 8086 MVTVGS-FLIFRRPVR--G-SEPGS-------------EAGPPRVKVPCISWV-PVLGSL-PWLRGGRPL 21 -------MLLLGLLLL--P-LLAGA-------------RLLWNWWKLRSLHLPPLAPGFL--HLLQPDL- 21 15 ---FSA-PPAVKRNLP--L-SLWQL-------------PLRPSSPPIPGPPCR-FLIGNM--TELMHDHL 3A4 --TWLL-LAVSLVLLY--L-YGTHS-------------HGLFKKLGIPGPTPL-PFLGNI--LSY-HKGF 3A5 --TWLL-LAVSLVLLY--L-YGTRT-------------HGLFKRLGIPGPTPL-PLLGNV--LSY-RQGL 3A7 --TWLL-LAVSLILLY--L-YGTRT-------------HGLFKKLGIPGPTPL-PFLGNA--LSF-RKGY 3A43 --TWVL-VATSLVLLY--I-YGTHS-------------HKLFKKLGIPGPTPL-PFLGTI--LFY-LRGL 3A47 600 --TWIL-LITFTCLFV--M-YGKRT-------------FGIFEKLGISGPKPT-MYFGSI--CKY-NN-V 3B1 2213a--TWAL-LALFFALLL--L-YGVWP-------------YHHFKKLGIRGPRPL-PFMGST--FYY-RKGI 3B2 2213b--TWTI-LVLFSTLLL--L-YGHWP-------------YRLFRKNGIPGPMPL-PFIGTM--WNL-LKGN 3A48 --TWTL-LTLIFTLII--V-YGYAP-------------YGFFKKVGIPGPKPW-PFIGTF--LNY-RRGI 3A49 --------------------YGYAP-------------YGFFKKVGISGPKPW-PFIGTF--LNY-KKGV 3A50P --TWTF-LILVIVLST--T----------------------IKRVGIRGPTPWAPLIGD---IFY----- 3A27 trout--TWTL-LALLITLIV--V-YGYWP-------------YGVFTKMGIPGPKPL-PYFGTM--LEY-KKGF 5A1 --TVAL-SVALLALLK--W-YSTSA-------------FSRLFKLGLRHPKPS-PFIGNL--TFF-RQGF 5A1 1244 --VTIR-LSVNTVLSF--R-YSVRP-------------FSVLSRNGIKHPKPL-PFFGNL--FMF-RQGF 4A11 VSGILQ-AASLLILLLLL----IKAVQLYLHRQ-----WLLKALQQFPCPPSH-WLFGHIQELQQD-QEL 4A22 VSGILQ-VTSLLILLLLL----IKAAQLYLHRQ-----WLLKALQQFPCPPSH-WLFGHIQEFQHD-QEL 4A20 MAHPFL-LLILLCMSLLL----FQVIRLYQRRR-----WMIRALHLFPAPPAH-WFYGHKEFYPVK-EFE 4B1 FSSLGL-WASGLILVLGF----LKLIHLLLRRR-----TLAKAMDKFPGPPTH-WLFGHALEIQET-GSL 4F2 --PWLL-LLLVGASWLLA----HVLAWTYAFYD-----NCRRLRCFPQPPRRN-WFWGHQGMVNPTEEGM 4F3 --PWLL-LLLVGASWLLA----RILAWTYTFYD-----NCCRLRCFPQPPKRN-WFLGHLGLIHSSEEGL 4F8 --PWLL-LLVVGASWLLA----RILAWTYAFYH-----NGRRLRCFPQPRKQN-WFLGHLGLVTPTEEGL 4F11 --PWLL-LLLVGGSWLLA----RVLAWTYTFYD-----NCRRLQCFPQPPKQN-WFWGHQGLVTPTEEGM 4F12 --PWLL-LLLVVGSWLLA----RILAWTYAFYN-----NCRRLQCFPQPPKRN-WFWGHLGLITPTEEGL 4F22 -RIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYI-----TCRRLRCFPQPPRRN-WLLGHLGMVSPNEAGL 4F28 2425 -WTSVCPLLAVLAAAPVALLTFWTAKLLVRHAW-----YTHRMACFSKPHARS-WLLGHLGQMQSTEEGL 4X1 --------PFYLAFVFCLALGLLQAIKLYLRRQ-----RLLRDLRPFPAPPTH-WFLGHQKFIQDDNMEK 4V2 ---LLLWGAASAVSLAGASLVLSLLQRVASYAR-----KWQQMRPIPTVARAY-PLVGHA--LLMKPDGR 4V5 485 ---GGFTLPLLGASVFVAALTCFTYRMLSDYLH-----KWFQMKPIPELEGTY-PLIGNA--LQFKPNAG 4T5 8637 ---LGWSHFYQLLALFCLAIVLYKLTVLLMLKR-----ALIRNFESFPGPPGH-WLFGNI--LEFKQDGN 4T2seabass---WGLPRLHHLLALLCLVAVVYKLATLLAKRR-----DVFRSYEDFPGPPTH-WLFGHV--LEFKQDGT 46 ---------MSPGLLLLGSAVLLAFGLCCTFVH-----RARSRYEHIPGPPRPSFLLGHLPCFWKKDEVG 46 4537 ---------ISQASIFLLLLLFIALLGYCMYIK-----YTHMKYDHIPGPPRDSFFSGHSSKLLDIMKDD 20 ----------MLDFAIFAVTFLLALVGAVLYLY-----PASRQAAGIPGITPTEEKDGNLP-DIVNSGSL 20 486 ----------MLDFAIFAVTFVIVLVGAVLYLY-----PSSRRASGIPGLNPTDEKDGNLQ-DIVGRGSL 26A1 SALCTF-VLPLLLFLAAL----KLWDLYCVSSR-----DRSCALPLPPGTMGF-PFFGET--LQM-VLQR 26A1 12575TFLCTI-VLPLLLFLVTV----KLWEVYVIRER-----DSACPSPLPPGTMGL-PFIGET--LQL-ILQR 26B1 4267 TLAACL-VSMALLLAVSQ----QLWQLRWTATR-----DRNCKLPMPKGSMGF-PFIGET--CHW-LLQG 26C1 11741TALTTL-LLLLLLLALTR----QLWSFRWSLTR-----DRRCELPLPKGSMGW-PLVGET--FQW-LFQG 26B1 LATLAACLVSVTLLLAVS---QQLWQLRWAATR-----DKSCKLPIPKGSMGF-PLIGET--GHW-LLQG 26C1 LGAAGTALLCAGLLLSLA---QHLWTLRWMLSR-----DRASTLPLPKGSMGW-PFFGET--LHW-LVQG 11A1 GYQTFL-SAPREGLGRLRVPTGEGAGIS-TRSP-----RPFNEIPS-PGDNGW-LNLYHF-WRETGTHKV 11A1 1630 LSRMEV-PMTGARHSSTMPVARQTYSDS-SSFV-----RSFNDIPG-LWKNGV-ANLYNF-WKLDGFRNL 11B1 KAEVCM-AVPWLSLQRAQALGTRAARV--PRTV-----LPFEAMPR-RPGNRW-LRLLQI-WREQGYEDL 11B2 KAEVCV-AAPWLSLQRARALGTRAARA--PRTV-----LPFEAMPQ-HPGNRW-LRLLQI-WREQGYEHL 11B1 fugu TAAGAV-VDGKVGACKGAEVPESKKGV--DGQV-----RSFEEIPH-TGRNSW-VNLLRF-WREDRFRHL 27A1 HGARAK-AAIPAALPSDKATGAPGAGPGVRRRQ-----RSLEEIPR-LGQ----LRFFFQ-LFVQGYAL- 27A1 3437 --------GLAPAPGAQGGSPQSQRLPPISASN-----HGRWRTFH-ASA----SGSCLQ-INVSGFHS- 27A2 697 CAAIGA-RNSALRPATLPSRNLNLQATSEAANL-----KGIADLPG-PNT----YKILYW-LFVKGYGE- 27A3 EGLHRT-AVNYAGARRRHASSAATEITEHNVRQ-----KTMEDLGG-PSF----LTTLNW-LFLKGYLP- 27B1 QTLKYA-SRVFHRVRWAPELGASLGYREYHSAR-----RSLADIPG-PST----PSFLAE-LFCKGGLS- 27B1 470 SCRSAS-PLVKWMERWAECASARPQAV-----------KPLGDMPG-PSV----ASFAWD-LFAKRGLS- 27C1 PAGARL-PAGARAEDKGAGRPGSPPGGGRAEGP-----RSLAAMPG-PRT----LANLAE-FFCRDGFS- 27C1 1410 KSATSG-TFGVAREEPLPERLITSTDATKKRLP-----KTLAEMPG-PGT----ISNLFE-FFWRDGFS- 24 RLVTST-AY-TSPQPREVPVCPLTAG-GETQN------AAALPGPT-SWPLLA-SLLQIL-WKGGLK--- 24 1804 --------------MLWRLRGALTLP-PELTV------LDAIPGPT-NWPLVG-SLFELL-RKGGLT--- 19 ---MLN-PIHYNITSIVPEAMPAATMSVLLLTGLFLLLWNYEGTSSIPGPGYC-MGIGPL--ISH-GRFL 19ov 7098 ---SVS-PNATEAESPGSSAGTRALIILTCLLLLVWSHTEKKSVPSLLGPSFC-LGFGPL--LTY-VRFI 19br 4200 ---TLN-ITASGPFTPLPLPLMMMMMMLLLMMMMLFLTWNRPQRQHVPGPLFL-AGLGPL--LSY-CRFM 8A1 --AALL-GLLAALLLLL----------LLSRRR-------TRRPGEPPLDLGSIPWLGYA--LDF-GKDA 8A2 5061 --MIWA-ALLGGLLTLV----------LLYFSR-------RRQDNEPPLDKGALPWLGHA--LEF-GRDA 8A1 4451 --MIWT-VLLLVHALL-----------LYFILR-------HRSRNEPPLDKGLIPWLGHA--LEF-GKDA 8B1 --VLGA-LLVVIAGYLC----------LPGMLR-------QRRPWEPPLDKGTVPWLGHA--MAF-RKNM 8B1 7782 --ILLT-FLVALLGGLY----------LLGVFR-------QRRPGEPPLDKGLIPWLGHV--LEF-RRNT 8B2 21917--ILLT-FLVALLGALY----------LLGVFR-------QRRPGEPPLDKGLIPWLGHV--LEF-CRNT 7B1 --LGLP-GLALAAALLLLALC------LLVRR--------TRRPGEPPLIKGWLPYLGVV--LNL-RKDP 7A1 IAACCC-LWL-----------------ILGIR--------RRQTGEPPLENGLIPYLGCA--LQF-GANP 7A1 5172 VGFCCL-LWL-----------------AVGIR--------HRHSSEPPVENGLIPYLGCA--LQF-GANP 7C1 16085---------------------------------------------------------------------- 39A1 ---LGC-LAL-----------------FLLLQ--------RKNLRRPPCIKGWIPWIGVG--FEF-GKAP 51 --AMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHA--IAF-GKSP 51 437 --IGDTVGRVHDNLTTVVLAASFITLSLGYVSKLLLRQSFVTDAKHPPYIPSCIPFLGHA--ISF-GKSP 2C9 ----SKSLTNLSK--VYG------PVFTLYFGL-KPIVVLHGYEAVKEAL-IDLGEEFSG----------- 2C19 ----SKSLTNLSK--IYG------PVFTLYFGL-ERMVVLHGYEVVKEAL-IDLGEEFSG----------- 2C18 ----SKSLTNFSK--VYG------PVFTVYFGL-KPIVVLHGYEAVKEAL-IDHGEEFSG----------- 2C8 ----CKSFTNFSK--VYG------PVFTVYFGM-NPIVVFHGYEAVKEAL-IDNGEEFSG----------- 2E1 ----PKSFTRLAQ--RFG------PVFTLYVGS-QRMVVMHGYKAVKEAL-LDYKDEFSG----------- 2F1 ----LTSLTKLSK--EYG------SMYTVHLGP-RRVVVLSGYQAVKEAL-VDQGEEFSG----------- 2W1 ----DRSLMELSE--RYG------PVFTVHLGR-QKTVVLTGFEAVKEAL-AGPGQELAD----------- 2B6 ----LKSFLRFRE--KYG------DVFTVHLGP-RPVVMLCGVEAIREAL-VDKAEAFSG----------- 2A6 ----YNSLMKISE--RYG------PVFTIHLGP-RRVVVLCGHDAVREAL-VDQAEEFSG----------- 2A7 ----CNSIMKFSE--CYG------PVFTIHLGP-RRVVVLCGHDAVREAL-VDQAEEFSG----------- 2A13 ----YNSLMKISE--RYG------PVFTIHLGP-RRVVVLCGHDAVKEAL-VDQAEEFSG----------- 2G1P ----FQSFMKLRE--KYS------PVFTVYMGP-RPVVVLCGHEAVKEAL-IDQADEFSG----------- 2G2P ----FQSFMKLRE--KYS------PVFTVYMGP-RPVVVLCGHEAVKEAL-VDQADEFSG----------- 2M1 trout----YKLYMELSK--KYG------SVFTVWLGS-KPVVVISGYQAIKDAF-VTQGEEFSG----------- 2J2 ----HLEVELFVK--KYG------NLFSLELGD-ISAVLITGLPLIKEAL-IHMDQNFGN----------- 2X2 4007----LQDFERLRK--KYG------NVYSLFLGT-RPAVVISGLKNIKEAL-VTKGSDFSG----------- 2X3 ----IADLERLAK--RYG------NVYGLFLGS-RPAVVINGVSAL------------------------- 2X1catfish----LKDFEKLAE--QYG------NICSLYIGT-KPAVVLNGLKVIREAL-VTKSADFSG----------- 2V1 Danio----HICLTKMSD--HYG------NIFSLRLGS-LNTVVVNTYSMVKKVL-NDQGNSFMY----------- 2Z2 2993b----HESLTQLAE--TYG------NVYSLRTGQ-TWMVVVNSFKVVREAL-VTHGESVSD----------- 2P3 killi----HLQLTEFAE--TYG------DIYSLHLFG-GRAVIINGYKHVKEAL-VQKGEDFMD----------- 2P4 ----HLQFAEFAG--KYG------NIFSLRLFG-GRVVVLNGYKTVREAL-VEKGENFVD----------- 2N2 killi----HVYFQKLAE--IYG------NVFSFRLGR-DSIVFLNGYKAVREAL-VTQAENFVD----------- 2N11 3261c----HNYFIQMAE--LYG------KLFSIRLGS-GKIVFACGYKMVKEAI-VTQADNFVD----------- 2N10 3261b----HLYFNKLAD--VHG------NVFSFRLGG-DKMVCVSGHKMVKEAI-VTQADNFVD----------- 2N12 3261d----FRTIEKLSQ--KYG------PVFSLRRGN-TRTVFINGYKMVKEAL-VSQLDSFED----------- 2N9 3261a----HLYLTKLAD--VYG------SVFCIRLGR-HKTVFVSGWKMVKEAI-VTQADSFVD----------- 2Y2 39b ----FKSFTELSK--SYG------PVMTLYLGW-QRTVVLTGYEVVKEAL-VDQAEDFTG----------- 2R1 7138 ----HVFLKKQSE--VHG------QIFSIDLGG-ILTVVLNGYDCIRECL-YNQSEVFAD----------- 2U1 8899 ----AAVLTELAK--VYG------NVYSIYVGS-QLVVVLNGYKVVRDAL-SNHPDVFSD----------- 2U1 ----QVLLAHLAR--VYG------SIFSFFIGH-YLVVVLSDFHSVREAL-VQQAEVFSD----------- 2Z1 2993a----HLNLMELAE--TYG------NVFSIQLGQ-EWMVVLNGPTILKEAL-VNQGDSVAD----------- 2K9 12487----DCHLVQLSQ--KYG------PIFRVYLAS-KKVVVLAGYTAVKQAL-VNQAEDFGE----------- 2K6 Danio----YLSLLELSK--KYG------PIYTVYLGP-KKVVILSGYKIVKEAL-VNLSEEFGD----------- 2Y1 39a ----FKSLLKLSE--NYG------PVLTVALGP-QRTVVLVGYEAVKDAL-VDHADDFTG----------- 2K10 19693----HQTLYQLSK--KYG------PVFKVHFGP-RKVVVLAGHKTVKEAL-VGNAEQFGD----------- 2K11 ----YNTLMKLSK--TYG------SVFTVYLGP-KKVVVLAGYKTVKEAL-IDHAEEFGE----------- 2R1 --LPHVYMRKQSQ--VYG------EIFSLDLGG-ISTVVLNGYDVVKECL-VHQSEIFAD----------- 2S1 ----YSGLMRLSK--KYG------PVFTIYLGPWRPVVVLVGQEAVREAL-GGQAEEFSG----------- 2T2P ----DRALHSLSG--RWG------RVFTVRLGP-RPAVGLCGYAALRDAL-VLQADAVSG----------- 2D6 ----PYCFDQLRR--RFG------DVFSLQLAW-TPVVVLNGLAAVREAL-VTHGEDTAD----------- 1A1 ----HLALSRMSQ--QYG------DVLQIRIGS-TPVVVLSGLDTIRQAL-VRQGDDFKG----------- 1A2 ----HLALSRMSQ--RYG------DVLQIRIGS-TPVLVLSRLDTIRQAL-VRQGDDFKG----------- 1B1 ----HLSFARLAR--RYG------DVFQIRLGS-CPIVVLNGERAIHQAL-VQQGSAFAD----------- 1B2 3008a----HITFSKLAK--KYG------NVYQIRLGC-SDIVVLNGARVIRQAL-IEHSTEFAG----------- 1B3 3008b----HITFAKLAK--KYG------NVYQIRLGC-SNIVVLNGDQAIHQAL-IEHSTEFAG----------- 1B1 1553 ----HLYFTRMAQ--RFG------NVFQIKLGS-RTVVVLNGD-AIKQAL-VRKGLEFAG----------- 17 ----HNNFFKLQK--KYG------PIYSVRMGT-KTTVIVGHHQLAKEVL-IKKGKDFSG----------- 17A1 4175 ----HVLFKELQG--KYG------QTYSLMMGS-HRVIIVNHHAHAKEVL-LKKGKIFAG----------- 17A2 8086 ----HLIFTQLSY--RYG------PLFALYLGP-HLTVVVNNHQHAREVL-LLRGKDFAG----------- 21 ----PIYLLGLTQ--KFG------PIYRLHLGL-QDVVVLNSKRTIEEAM-VKKWADFAG----------- 21 15 ----PIHLTNLAK--RYG------NIYRLKCGNTTAMIVLNSSDIIREAL-VKKWSDFAG----------- 3A4 ----CMFDMECHK--KYG------KVCGFYDGQ-QPVLAITDPDMIKTVL-VK--ECYSV----------- 3A5 ----WKFDTECYK--KYG------KMWGTYEGQ-LPVLAITDPDVIRTVL-VK--ECYSV----------- 3A7 ----WTFDMECYK--KYR------KVWGIYDCQ-QPMLAITDPDMIKTVL-VK--ECYSV----------- 3A43 ----WNFDRECNE--KYG------EMWGLYEGQ-QPMLVIMDPDMIKTVL-VK--ECYSV----------- 3A47 600 ----YYLDQECAQ--KYG------KIWGTYELR-KPMLVVMDPDLLKTIL-VK--ECFTH----------- 3B1 2213a----IPFESWCQA--EYG------DVWGMFEGR-TPVLMVSDPEILKTVL-VK--ECYSV----------- 3B2 2213b----MVFDRECQS--KYG------DVWGVFEGR-TPVLMVSDPGMIKTIL-VK--ECYSV----------- 3A48 ----HHFDEECYK--KYG------KVWGLYDGR-QPLMCIMDTGMIKTVL-VK--ECYSN----------- 3A49 ----HHFDEECYK--KYG------KVWGLYDGR-QPLMCIMDTGIIKTIL-VK--ECYSN----------- 3A50P ----STRRGKCCK--RYG------KVWGLYEGR-IPVMFIVDTAMIKTVF-VK--EGYSV----------- 3A27 trout----TNFDTECFQ--KYG------RIWGIYDGR-QPVLCIMDKSMIKTVL-IK--ECYNI----------- 5A1 ----WESQMELRK--LYG------PLCGYYLGR-RMFIVISEPDMIKQVL-V---ENFSN----------- 5A1 1244 ----FNPLNDLIK--THG------RVCGYYLGR-KPVVVVADPEMLRQVM-V---KDFSS----------- 4A11 ----QRIQKWVET--TFP------SACPHWLWGGKVRVQLYDPDYMKVIL-GR--SDPKS----------- 4A22 ----QRIQERVKT---FP------SACPYWIWGGKVRVQLYDPDYMKVIL-GR--SDPKS----------- 4A20 -----VYHKLME---KYP------CAVPLWVGPFTMFFSVHDPDYAKILL-KR--QDPKS----------- 4B1 ----DKVVSWAH---QFP------YAHPLWFGQFIGFLNIYEPDYAKAVY-SR--GDPKA----------- 4F2 ----RVLTQLVA---TYP------QGFKVWMGPISPLLSLCHPDIIRSVI-NA--SAAIA----------- 4F3 ----LYTQSLAC---TFG------DMCCWWVGPWHAIVRIFHPTYIKPVL-FA--PAAIV----------- 4F8 ----RVLTQLVA---TYP------QGFVRWLGPITPIINLCHPDIVRSVI-NT--SDAIT----------- 4F11 ----KTLTQLVT---TYP------QGFKLWLGPTFPLLILCHPDIIRPIT-SA--SAAVA----------- 4F12 ----KNSTQMSA---TYS------QGFTIWLGPIIPFIVLCHPDTIRSIT-NA--SAAIA----------- 4F22 ----QDEKKVLD---NMH------HVLLVWMGPVLPLLVLVHPDYIKPLL-GA--SAAIA----------- 4F28 2425 ----LQVDELVQ---MFT------YCCSWFIGPFYHLVRVFHPDYVKPLL-MA--PASIV----------- 4X1 ----LEEIIE-----KYP------RAFPFWIGPFQAFFCIYDPDYAKTLL-SR--TDPKS----------- 4V2 EFFQQIIEYTEEY--RHM------PLLKLWVGPVPMVALYNAENVEGILT-SS--KQIDK----------- 4V5 485 DFFNQIVEYTREN--YHR------PLFKIWVGPVPFVVLFHPETVEPVLT-NA--VHMEK----------- 4T5 8637 ---DLDKLVKFGQ--KYP------YCFPLWFGPFVFLNIHHPEYVKTILA-ST------E----------- 4T2seabass---DFDTLMAWTK--QYP------YAFPLWFGPFCVLNIHHPDYVKTILA-ST------E----------- 46 GRVLQDVFLDWAK--KYG------PVVRVNVFHKTSVIVTSPESVKKFLM-ST--KYNKD----------- 46 4537 G-VVHDMFLKWAE--TYG------PVYKIYFLHHVMVFVSCPETTKEMLM-SP--KYTKD----------- 20 ----HEFLVNLHE--RYG------PVVSFWFGRRLVVSLGTVDVLKQHIN-PN--KTSDP----------- 20 486 ----HEFLVSLHQ--EFG------PVASFWFGSRPVVSLGSLQQLRQHIN-PN--HSTDS----------- 26A1 ----RKFLQMKRR--KYG------FIYKTHLFG-RPTVRVMGADNVRRIL-LG--DDRLVS---------- 26A1 12575----RKFLRMKRQ--KYG------YIYRTHLFG-NPTVRVTGANNVRHIL-LG--EHRLVA---------- 26B1 4267 ----SGFHASRRQ--KYG------NVFKTHLLG-RPLIRVTGAENIRKVL-MG--EHTLVT---------- 26C1 11741----SNFHISRRK--RHG------NVFKTHLLG-KPLVRVTGAENIRKIL-LG--EHSLVC---------- 26B1 ----SGFQSSRRE--KYG------NVFKTHLLG-RPLIRVTGAENVRKIL-MG--EHHLVS---------- 26C1 ----SRFHSSRRE--RYG------TVFKTHLLG-RPVIRVSGAENVRTIL-LG--EHRLVR---------- 11A1 ----HLHHVQNFQ--KYG------PIYREKLGN-VESVYVIDPEDVALL--FKSEGP-------------- 11A1 1630 ----HHIMVQNFN--TFG------PIYREKIGY-YESVNIINPEDAAIL--FKAEGH-------------- 11B1 ----HLEVHQTFQ--ELG------PIFRYDLGG-AGMVCVMLPEDVEKL--QQVDSL-------------- 11B2 ----HLEMHQTFQ--ELG------PIFRYNLGG-PRMVCVMLPEDVEKL--QQVDSL-------------- 11B1 fugu ----HKHMERNFN--SLG------PIYREPVGA-PNSVNIMLPSDISEL--SRSEGL-------------- 27A1 --QLHQLQVLYKA--KYG------PMWMSYLGP-QMHVNLASAPLLEQV--MRQEGK-------------- 27A1 3437 --HMHELQILEKG--RYG------PIYR---NG-MNAVSVSTAKLLGEV--LRNDDK-------------- 27A2 697 --RSHLLQGKLKN--IYG------PMWRWKLGP-YDFVSVASPELIARV--IQQEGR-------------- 27A3 --KTQQMQVEHSK--IYG------PLWKSKYGP-MVVVNVASADLIEQV--LRQEGR-------------- 27B1 --RLHELQVQGAA--HFG------PVWLASFGT-VRTVYVAAPALVEEL--LRQEGP-------------- 27B1 470 --RLHELQLEGVR--RYG------PMWKASFGP-ILTVHVADPALIEQV--LRKEGQ-------------- 27C1 --RIHELQQKHTR--EYG------KIFKSHFGP-QFVVSIADRDMVAQV--LRAEGA-------------- 27C1 1410 --RIHEIQIEHSK--MYG------KIFKSRFGP-QLVVSVADRDLVAEV--LRAEGV-------------- 24 --KQHDTLVEYHK--KYG------KIFRMKLGS-FESVHLGSPCLLEAL--YRTESV-------------- 24 1804 --RQHEALVDYHK--KFG------KIFRLKLGS-FESVHIGAPCLLESL--YRTEGS-------------- 19 WMGSRSACNYYNR--VYG-----EFMRVWISGE-ETLIISKSSSMFH-I--MKHNHYSSRFG--------- 19ov 7098 WTGIGTASNYYNK--KYG-----DIVRVWVNGE-ETLVISRASAVHH-V--LKSRQYTSRFG--------- 19br 4200 WTGIGTACNFYNN--KYG-----SLVRVWINGE-ETLILSRSSAVYH-V--LRSAHYTARFG--------- 8A1 ----ASFLTRMKE--KHG-----DIFTILVGG--RYVTVLLDPHSYD-A--VVWEPRTRL----------- 8A2 5061 ----AKFLARMKE--KHG-----DVFTVRVAG--QYITVLLDANSFD-S--VLNDTVSL------------ 8A1 4451 ----SKFLERMKR--KHG-----DIFTVRAAG--RYVTVLLDPHSYD-Q--VIHDQDCL------------ 8B1 ----FEFLKRMRT--KHG-----DVFTVQLGG--QYFTFVMDPLSFGPI--LKDTQRKL------------ 8B1 7782 ----WRFLERMEK--KHG-----DVFTVQLAG--FYITFIQDPMSFGAF--VKESREKL------------ 8B2 21917----WRFLERMEK--KHG-----DVFTVQLAG--FYITFIQDPMSFGAF--VKESREKL------------ 7B1 ----LRFMKTLQK--QHG-----DTFTVLLGG--KYITFILDPFQYQLV--IKNHKQLS------------ 7A1 ----LEFLRANQR--KHG-----HVFTCKLMG--KYVHFITNPLSYHKV--LCHGKYFD------------ 7A1 5172 ----LQFLRSRQK--KYG-----HIFTCKIAG--QYIHFLCDPFSYHSV--IRQGRHLD------------ 7C1 16085--------------------------SCAPAG--KYMTFIMDPLMYPNI--IKHGRQLD------------ 39A1 ----LEFIEKARI--KYG-----PIFTVFAMG--NRMTFVTEEEGINVFL-KSKKVDF------------- 51 ----IEFLENAYE--KYG-----PVFSFTMVG--KTFTYLLGSDAAALLF-NSKNEDLNA----------- 51 437 ----IEFLENAYE--KYG-----PVFSFTMVG--STFTYLLGSDAAALLF-NSKNEDLNA----------- 2C9 -----RGI-FPLAERANR-------GFG-IVFS--NGKKWKEIRRFSLMTLRNFGMGK---------RSIE 2C19 -----RGH-FPLAERANR-------GFG-IVFS--NGKRWKEIRRFSLMTLRNFGMGK---------RSIE 2C18 -----RGS-FPVAEKVNK-------GLG-ILFS--NGKRWKEIRRFCLMTLRNFGMGK---------RSIE 2C8 -----RGN-SPISQRITK-------GLG-IISS--NGKRWKEIRRFSLTTLRNFGMGK---------RSIE 2E1 -----RGD-LPAF-HAHR-------DRG-IIFN--NGPTWKDIRRFSLTTLRNYGMGK---------QGNE 2F1 -----RGD-YPAFFNFTK-------GNG-IAFS--SGDRWKVLRQFSIQILRNFGMGK---------RSIE 2W1 -----RPP-IAIFQLIQR-------GGG-IFFS--SGARWRAARQFTVRALHSLGVGR---------EPVA 2B6 -----RGK-IAMVDPFFR-------GYG-VIFA--NGNRWKVLRRFSVTTMRDFGMGK---------RSVE 2A6 -----RGE-QATFDWVFK-------GYG-VVFS--NGERAKQLRRFSIATLRDFGVGK---------RGIE 2A7 -----RGE-QATFDWVFK-------GYG-VAFS--NGERAKQLLRFAIATLRDFGVGK---------RGIE 2A13 -----RGE-QATFDWLFK-------GYG-VAFS--NGERAKQLRRFSIATLRGFGVGK---------RGIE 2G1P -----RGE-LASIKQNFQ-------GHGGVALA--NGERWRILRRFSLTILRDFGMGK---------QSIK 2G2P -----RGE-LASIKQNFQ-------GHG-VALA--NGERWRIL*RFPLTILRDFGMGK---------RSIE 2M1 trout-----RAN-YPVIMTVSK-------GYG-VLVS--SGKRSKDLRRFSLMTLKTFGMGR---------RSIE 2J2 -----RPV-TPMREHIFK-------KNG-LIMS--SGQAWKEQRRFTLTALRNFGLGK---------KSLE 2X2 4007-----RPQDMILSIDAIK-------TNV-IMQD--YNLVWKEHRRFALTTMRNFGMGK---------TSME 2X3 ----------------------------LLLSP--YNSGWREHRRFTLMTLRNFGLGK---------QSME 2X1catfish-----RPQNMLKDVTEGK-------GIV-IA-D--YGRQWKEHRRFALMTLRNFGLGK---------QSME 2V1 Danio-----RPSNDITERILSK-------CQG-LTFN--NGYSWKQHRRFTLSTLKFFGVGK---------RSLE 2Z2 2993b-----RPD-LPLQDEIAH-------GKG-VISS--NGHLWKQQRRFALSTLRLFGFGK---------KSLE 2P3 killi-----RPN-IPLFADFFN-------NKG-LVMS--NGYQWKVQRRFALHTLRNFGLGK---------KAME 2P4 -----RPL-IPLFEAFAG-------NRG-LVIS--NGNPWKHQRRFALHTLRNFGIGK---------KSLE 2N2 killi-----RPFNAITDRFYTEP------SAG-IFMS--NGEKWKKQRRFALSTLRNFGLGK---------NSLE 2N11 3261c-----RPF-NAFGDRIYMGQ-----RDG-LFQN--NGEVWKRQQHFALSTLRNFGLGK---------NILE 2N10 3261b-----RPY-DPISARVYGGQ-----TDG-LFQS--NGEVWKRQRRFALSTLRNFGLGK---------NILE 2N12 3261d-----RPV-VPLFHVVFKGI-------G-IALS--NGYMWKKQRKFAHTHLRYFGEGQ---------KLLE 2N9 3261a-----RPY-SPMATRIYSGN-----SAG-LFFS--NGHVWRKQRRFAMATLRSFGLAN---------GSME 2Y2 39b -----RGP-LPFLLKATN-------GYG-LGIS--NGERWRQLRRFTLSTLRDFGMGR---------KGME 2R1 7138 -----RPS-LPLFKKMTKM------GGL-LNCK--YSKGWIEHRKLACNSFRYFGSGQ---------RLFE 2U1 8899 -----RPD-IPAISIMTKI------SGI-VFAP--YGPLWQKHRRFCLSTLRNFGLGR---------LGLE 2U1 -----RPR-VPLISIVTKE------KGV-VFAH--YGPVWRQQRKFSHSTLRHFGLGK---------LSLE 2Z1 2993a-----RPN-LQLIIDSCH-------GLG-LGFS--SGHLWKQQRQFAISTLRYFGSGS---------KSLE 2K9 12487-----REI-FPIFHDFNK-------GNG-ILFT--NGDQWKEMRRFALMTLKDFGMGK---------RTIE 2K6 Danio-----RDI-SPIFHDFNR-------GYG-IAFS--NGENWREMRRFALSTLRDFGMGR---------KRSE 2Y1 39a -----RGP-VPFLMKVTR-------GYG-LAIS--NGERWRQLRRFTLTTLRDFGMGR---------KGME 2K10 19693-----RDI-SPIFYDMNQ-------GHG-ILFS--NGETWKEMRRFALSTLRDFGMGK---------RMIE 2K11 -----RDP-IMLVQNANH-------EHG-VLWS--NGESWKEMRRFALTNLRDFGMGK---------KACE 2R1 -----RPC-LPLFMKMTK-------MGG-LLNS-RYGRGWVDHRRLAVNSFRYFGYGQ---------KSFE 2S1 -----RGT-VAMLEGTFD-------GHG-VFFS--NGERWRQLRKFTMLALRDLGMGK---------REGE 2T2P -----RGS-MAVFERFTR-------GNG-ILFS--NRPCWWTLRNFALGALKKFGLGT---------RTVE 2D6 -----RPP-VPITQILGFGPR----SQG-VFLAR-YGPAWREQRRFSVSTLRNLGLGK---------KSLE 1A1 -----RPD-LYTFTLISN-------GQS-MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS--CYLE 1A2 -----RPD-LYTSTLITD-------GQS-LTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS--CYLE 1B1 -----RPA-FASFRVVSG-------GRS-MAFG-HYSEHWKVQRRAAHSMMRNFFTRQPRSR-----QVLE 1B2 3008a-----RPN-FVSFQNVSG-------GKS-MAFT-SYSKQWRMHRKIAQSTIRAFSSANSQTK-----KVFE 1B3 3008b-----RPN-FVSFQMISG-------GRS-LTFT-NYSKQWKVHRKLAQSSLRAFSSANKQTK-----IAFE 1B1 1553 -----RPD-FTSFKYISN-------GHS-LAFG-TVTDWWKSHRRVAQSTVRMFSTGNLQTK-----KTFE 17 -----RPQ-MATLDIASNN------RKG-IAFA-DSGAHWQLHRRLAMATFALFKDGD---------QKLE 17A1 4175 -----RPR-SVTTDVLSRD------GKD-IAFG-DYSATWRFHRKIVHGALCMFGEGS---------ASIE 17A2 8086 -----RPR-MVTTDLLTRG------GKD-IAFS-DYCPLWKSHRRLVQNSFTLFGEGT---------SRLQ 21 -----RPE-PLTYKLVSKN------YPD-LSLG-DYSLLWKAHKKLTRSALLLGIRDS-----------ME 21 15 -----RAV-SYTADIVSGG------GRN-ISLG-DYTEEWKALRRLVHGALQRCCKHS-----------LH 3A4 -----FTN-RRPFGPVGFM------KSA-ISIA--EDEEWKRLRSLLSPTFTSGKLKE-----------MV 3A5 -----FTN-RRSLGPVGFM------KSA-ISLA--EDEEWKRIRSLLSPTFTSGKLKE-----------MF 3A7 -----FTN-RRPFGPVGFM------KNA-ISIA--EDEEWKRIRSLLSPTFTSGKLKE-----------MV 3A43 -----FTN-QMPLGPMGFL------KSA-LSFA--EDEEWKRIRTLLSPAFTSVKFKE-----------MV 3A47 600 -----FTN-RRNFCLNGDL------YDA-VNIA--EDDDWRRIRNVLSPLFTTGRIKQ---------IFSL 3B1 2213a-----FTN-RR-DSFAGPL------EDS-VSAV--KDERWKRIRSTISPCFTSGRLKN---------AFPI 3B2 2213b-----FTN-HRVRIFSGPL------ETS-VFSA--KDETWKRMRTSISPCFTSGRLRQ---------AFPI 3A48 -----FTN-RRDLGVNGPL------SDA-VSVA--EDEQWKRIRGILSPSFTSGRLKE---------MYTI 3A49 -----FTN-RRDLGLNGPL------RDA-VSVA--EDEQWKRIRGILSPSFTSGRLKE---------MYTI 3A50P -----FLN-RKSIGPNGIL------STG-LPFL--RDDNWKRVHKIVSPAFSSGRMKD---------MFSI 3A27 trout-----FTN-RRNFHLNGEL------FDA-LSVA--EDDTWRRIRSVLSPSFTSGRLKE---------MFGI 5A1 -----FTN-RMASGLEFKSV-----ADS-VLFL--RDKRWEEVRGALMSAFSPEKLNE-----------MV 5A1 1244 -----FPN-RMSLRFITKPM-----SDC-LLML--RNERWKRVRSILTPAFSASKMKE-----------MV 4A11 -----HGS-YRFLAPWI--------GYG-LLLL--NGQTWFQHRRMLTPAFHYDILKP-----------YV 4A22 -----HGS-YKFLAPRI--------GYG-LLLL--NGQTWFQHRRMLTPAFHNDILKP-----------YV 4A20 -----AVS-HKILESWV--------GRG-LVTL--DGSKWKKHRQIVKPGFNISILKI-----------FI 4B1 -----PDV-YDFFLQWI--------GRG-LLVL--EGPKWLQHRKLLTPGFHYDVLKP-----------YV 4F2 --PKDKFF-YSFLEPWL--------GDG-LLLS--AGDKWSRHRRMLTPAFHFNILKP-----------YM 4F3 --PKDKVF-YSFLKPWL--------GDG-LLLS--AGEKWSRHRRMLTPAFHFNILKP-----------YM 4F8 --DKDIVF-YKTLKPWL--------GDG-LLLS--VGDKWRHHRRLLTPAFHFNILKP-----------YI 4F11 --PKDMIF-YGFLKPWL--------GDG-LLLS--GGDKWSRHRRMLTPAFHFN-LKP-----------YM 4F12 --PKDNLF-IRFLKPWL--------GEG-ILLS--GGDKWSRHRRMLTPAFHFNILKS-----------YI 4F22 --PKDDLF-YGFLKPWL--------GDG-LLLS--KGDKWSRHRRLLTPAFHFDILKP-----------YM 4F28 2425 --VKDELI-YDHLRPWL--------GNS-LLLS--NGEAWSRRRRLLTPAFHFDILKN-----------YV 4X1 -----QYL-QKFSPPLL--------GKG-LAAL--DGPKWFQHRRLLTPGFHFNILKA-----------YI 4V2 -----SSM-YKFLEPWL--------GLG-LLTS--TGNKWRSRRKMLTPTFHFTILED-----------FL 4V5 485 -----SYS-YSFLHPWL--------GTG-LLTS--TGPKWRRRRKMLTPTFHFSILAD-----------FL 4T5 8637 --PKDDLA-YSFIQNWI--------GNG-LLVS--QGQKWFRHRRLLTPGFHYDVLKP-----------YV 4T2seabass--PKDDVS-YRFILSWI--------GEG-LLVS--SGQKWFRHRRFLTPGFHYDVLKP-----------YV 46 -----SKM-YRALQTVFGERLF---GQG-LVSE-CNYERWHKQRRVIDLAFSRSSLVS-----------LM 46 4537 -----KFL-HNRIGSLFGQRFL---GNG-LVTV-RDHEKWYKQRRIMDPAFSSLYLRS-----------LM 20 -----FET-MLKSLLRYQS------GGG-SVSE------NHMRKKLYENGVTDSLKSN-----------FA 20 486 -----FET-MLKSLLGYHS------GGG-GAST------DSIIRKKVYQGAIDTT-KN------------- 26A1 -----VHW-PASVRTIL--------GSG-CLSN-LHDSSHKQRKKVIMRAFSREALEC-----------YV 26A1 12575-----VQW-PASVRTIL--------GSD-TLSN-VHGAQHKTKKKAIMQAFSREALEF-----------YI 26B1 4267 -----VDW-PQSTSTLL--------GPN-SLAN-SIGDIHRKKRKVFAKVFSHEALES-----------YL 26C1 11741-----TQW-PQSTRIIL--------GPN-ALVN-SIGELHKRKRKILAKVFSRKALES-----------YL 26B1 -----TEW-PRSTRMLL--------GPN-TVSN-SIGDIHRNKRKVFSKIFSHEALES-----------YL 26C1 -----SQW-PQSAHILL--------GSH-TLLG-AVGEPHRRRRKVLARVFSRAALER-----------YV 11A1 -----NPE-RFLIPPWVAYHQYYQRPIG-VLLK--KSAAWKKDRVALNQEVMAPEATK-------NFLPLL 11A1 1630 -----YPK-RLKVEAWTSYRDYRNRKYG-VLLK--NGEEWRCNRVLLNKEVISPKVLE-------NFVPLL 11B1 -----HPH-RMSLEPWVAYRQHRGHKCG-VFLL--NGPEWRFNRLRLNPEVLSPNAVQ-------RFLPMV 11B2 -----HPC-RMILEPWVAYRQHRGHKCG-VFLL--NGPEWRFNRLRLNPDVLSPKAVQ-------RFLPMV 11B1 fugu -----HPR-RMTLQPWATHRETRKHGKG-GFHK--NGEEWRADRLLLNKEVMMSEAVR-------RFIPLL 27A1 -----YPV-RNDMELWKEHRDQHDLTYG-PFTT--EGHHWYQLRQALNQRLLKPAEAA-------LYTDAF 27A1 3437 -----FPN-RGDMSIWKEYRDLRGYGYG-PFTE--KDERWYNLRAVLNKRMLRPKDAL------QYGDTIG 27A2 697 -----YPV-RVQLPHWKEYRDLRGQAYG-LHVE--TGPEWSRLRSALKPRMLKLREVV-------ALSPDE 27A3 -----HPV-RTDMPHWRRYRALRNQAHG-PLTE--XXXXXXXIRSILNPRMLKPQHVS-------SYGITI 27B1 -----RPE-RCSFSPWTEHRRCRQRACG-LLTA--EGEEWQRLRSLLAPLLLRPQAAA-------RYAGTL 27B1 470 -----HPM-RSDLSSWKDYRRLRGHHYG-LLTS--EGEEWQSIRSLLGKHMLRPKAVE----------AYD 27C1 -----APQ-RANMESWREYRDLRGRATG-LISA--EGEQWLKMRSVLRQRILKPKDVA---IYSGEV---- 27C1 1410 -----APQ-RANMESWHEYRDMRRRSTG-LISA--EGEDWLRMRSVLRQLIMRPRDVA---VFSDDVSEVV 24 ------PQ-RLEIKPWKAYRDYRKEGYG-LLIL--EGEDWQRVRSAFQKKLMKPGEVM-------KLDNKI 24 1804 -----YPQ-RLEIKPWTAYRDMRDEAYG-LLIL--EGKDWQRVRRAFQQKLMKPTEVV-------KLDRKI 19 -----SKL-GLQ--CIGMH------EKG-IIFN-NNPELWKTTRPFFMKALSGPGLVR-----------MV 19ov 7098 -----SKQ-GLS--CIGMN------ERG-IIFN-NNVTEWRKIRGYFTKALTGPAVQN-----------TV 19br 4200 -----SRA-GLE--CIGME------GQG-VIFN-SDVQLWRRARVYFSKALTGPGLQR-----------TV 8A1 -------D-FHAYAIFLMERIF---DVQ------LPHYSPSDEKARMKLTLLHRELQA-----------LT 8A2 5061 -------D-FVKSKNQLLERIF---FLK------LPGLQPAAEREWMEQHFHGFRLSN-----------LS 8A1 4451 -------D-FHSYAKVLMERIF---QLR------LPNHEPAKEKAVMTQHFLGMNLCG-----------LN 8B1 -------D-FGQYAKKLVLKVF---GYR------SVQGDHEMIHSASTKHLRGDGLKD-----------LN 8B1 7782 -------D-FRKFASHLVRRVF---GYS------SIQNDHDILNASSNRHLKGDGLEV-----------MT 8B2 21917-------D-FRKFASHLVRRVF---GYI------ATKADHEMLNASSNRHLKGDGLEV-----------MT 7B1 -----FRV-FSNKLLEKAFSIS-----Q-LQKN--HDMNDELHLCYQF--LQGKSLDI-----------LL 7A1 -----WKK-FHFATSAKAFGHR-----S-IDPM--DGNTTENINDTFIKTLQGHALNS-----------LT 7A1 5172 -----WRK-FHFATSVKAFGHD-----S-FDPR--HGHTTENLHQTFLKTLQGEALPS-----------LI 7C1 16085-----FHS-FSDSMAPVVFGYP-----P-VRSW--KTPSLHEDIQRAFKLLQGDHLCA-----------LT 39A1 -----ELA-VQNIVYRTASIPK-----N-VFLA-LHEKLYIMLKGKMGTVNLHQFTGQ-----------LT 51 -----EDV-YSRLTTPVF-------GKG-VAYDV-PNPVFLEQKKMLKSGLNI-----------AHFKQHV 51 437 -----EDV-YSRLTTPVF-------GKG-VAYDV-PNPIFLEQKKMLKTGLNI-----------AHFKEHV 2C9 DRVQEEARCLVEELRKTKASPCD---------PTFIL-GCAPCNVICSIIF-------HKRF--DYKDQQF 2C19 DRVQEEARCLVEELRKTKASTCD---------PTFIL-GCAPCNVICSIIF-------QKRF--DYKDQQF 2C18 DRVQEEARCLVEELRKTNASPCD---------PTFIL-GCAPCNVICSVIF-------HDRF--DYKDQRF 2C8 DRVQEEAHCLVEELRKTKASPCD---------PTFIL-GCAPCNVICSVVF-------QKRF--DYKDQNF 2E1 SRIQREAHFLLEALRKTQGQPFD---------PTFLI-GCAPCNVIADILF-------RKHF--DYNDEKF 2F1 ERILEEGSFLLADVRKTEGEPFD---------PTFVL-SRSVSNIICSVLF-------GSRF--DYDDERL 2W1 DKILQELKCLSGQLDGYRGRPF----------PLALL-GWAPSNITFALLF-------GRRF--DYRDPVF 2B6 ERIQEEAQCLIEELRKSKGALMD---------PTFLF-QSITANIICSIVF-------GKRF--HYQDQEF 2A6 ERIQEEAGFLIDALRGTGGANID---------PTFFL-SRTVSNVISSIVF-------GDRF--DYKDKEF 2A7 ERIQEESGFLIEAIRSSHGANID---------PTFFL-SRTVSNVISSIVF-------GDRF--DYEDKEF 2A13 ERIQEEAGFLIDALRGTHGANID---------PTFFL-SRTVSNVISSIVF-------GDRF--DYEDKEF 2G1P ERIQEEASYLLEEFQKTK----------------------------------------------------- 2G2P ERIQEEASYLLEEFRKTKGAPID---------PIFLL-SRTVSNVISSVVF-------RSRF--DYEDKQF 2M1 troutERVQEEAKMLVKAFGEYRDSVVN---------PKELL-CNCVGNVICSIVF-------GHRF--ENDDPMF 2J2 ERIQEEAQHLTEAIKEENGQPFD---------PHFKI-NNAVSNIICSITF-------GERF--EYQDSWF 2X2 4007DRIHGEIEYIVNTLEKNNGKTLS---------PHLMF-HNAASNIICQVLF-------GTRY--EYDDHFI 2X3 DRILGEMRRVMEFLEQSDGEPIN---------PETLF-HKAASNIIFQVLF-------AKRF--DNEDDSM 2X1catfishNRILGEIEHLVAKLEKYAGSSMY---------PQTLF-HDAASNIIYLVLF-------GTRY--DYGDETL 2V1 DanioFIIMEEYKFLHQSILDTNGLPFN---------PHYII-NNGVSNIICSMVF-------GRRF--EYTDQRF 2Z2 2993bPFITDEFTHCANIFRSYKGKPLP---------PHLIL-NNVVSNIICSLVF-------GHRF--EYGDKNF 2P3 killiRYIQQECQYLNEAFSEQQGKPFN---------GQALI-NNAVSNIICCLVF-------GNRY--EYNDKQY 2P4 PSIQQECHYLAEAFAQHKG---------------------------------------------------- 2N2 killiQSVSEEIQHLQEEMEIEKGKPFN---------PSGLF-TNAVSNIICQLVM-------GKRY--DYTDHRF 2N11 3261cQSICEEAQHLLEEMRSHGGKPFD---------PASLF-TRAVSNIICQLVM-------GKRF--EYSDHKF 2N10 3261bQSICEEAQHLLEEMRSHGGKPFN---------PARLF-NNTVSNIICQLVM-------GKRF--EYSDHKF 2N12 3261dNHIQMESKFMCEAFKDEQGKPFD---------PQYTI-TNAVGNIISALVF-------GHRF--EYSDASF 2N9 3261aLSICEESRHLQEAMESQKGEPFD---------PVPLL-NNAVANIICQIVF-------GRRF--DYTDHMF 2Y2 39b EWIQEESKHLTARIKTLKVKPFD---------PTFLL-GCTVSNVICCMVF-------GERF--SYDDKQF 2R1 7138 RKISEECMFLVDAIDQHKGKAFN---------PKHLV-TNAVSNITNLIIF-------GQRF--TYDDHNF 2U1 8899 PCIVEGLTNIKTELLRLEEESGGAGVD-----PAPVI-SNAVSNVICSLVL-------GHRF--NHDDQEF 2U1 PKIIEEFKYVKAEMQKHGEDPFC---------PFSII-SNAVSNIICSLCF-------GQRF--DYTNSEF 2Z1 2993aPVVLEEFAHCAKQFSEFKGKPFA---------PQLMF-YNIVTNIICSLVF-------GHRF--EYGDKNF 2K9 12487EKIIKECQYLIEAFEQHQGEAFS---------NAQVI-SYATSNIISAIMY-------GRRF--DYKDPTF 2K6 DanioELIIEEIKYVKEEFEKFGGNPFE---------TKLPL-ALAISNIIASIVF-------SVRF--EYSNTKL 2Y1 39a EWIQEESKHLVTRIKSTEGAPFD---------PTFFL-SCTVSNVICCLVF-------GQRF--SYDDEHF 2K10 19693DKIAEECQyliqkfeeheektfd---------tsrla-nYATSNIISSIVY-------GSRF--DYDDPRF 2K11 NKIIEECSYLMEELKKWKGEPFD---------TTHPI-NYAVSNIICSMVY-------GNRF--EYDDPEF 2R1 SKILEETKFFNDAIETYKGRPFD---------FKQLI-TNAVSNITNLIIF-------GERF--TYEDTDF 2S1 ELIQAEARCLVETFQGTEGRPFD---------PSLLL-AQATSNVVCSLLF-------GLRF--SYEDKEF 2T2P ARVLEEAACLLDEFQATIGAPFD---------PVRLL-DNAVSNVICSLVF-------GNRY--RYGDPEF 2D6 QWVTEEAACLCAAFANHSGRPFR---------PNGLL-DKAVSNVIASLTC-------GRRF--EYDDPRF 1A1 EHVSKEAEVLISTLQELMAGPGHFN-------PYRYV-VVSVTNVICAICF-------GRRY--DHNHQEL 1A2 EHVSKEAKALISRLQELMAGPGHFD-------PYNQV-VVSVANVIGAMCF-------GQHF--PESSDEM 1B1 GHVLSEARELVALLVRGSADGAFLD-------PRPLT-VVAVANVMSAVCF-------GCRY--SHDDPEF 1B2 3008aQQIVAEATELVEVFLKLGARGQHFN-------PAHEL-TVAAANVICALCF-------GRRY--GHDDQEF 1B3 3008bQHVTAEANELVQAFLRYSTDGRYFD-------PAHEF-TVAAANVMCALCF-------GKRY--GHDDHEF 1B1 1553 RHLTCEVRELLHLFLGKTKELQYFQ-------PMNYL-VVSTANVISAVCF-------GKRY--SYEDEEF 17 KIICQEISTLCDMLATHNGQSID---------ISFPV-FVAVTNVISLICF-------NTSY--KNGDPEL 17A1 4175 KIICAEAASLCSILSEAWTAGLALD-------LSPEL-TRAVTNVICSLCF-------SSSY--RRGDAEF 17A2 8086 DMVLAAVDSLCEELLSME--GRGFD-------PAPAV-TRAVTNVVCMLVF-------SATY--RHGDSEL 21 PVVEQLTQEFCERMRAQPGTPVA---------IEEEF-SLLTCSIICYLTF-------GDKI---KDDNLM 21 15 NVIERQALQLRKVLVDYRGGAVD---------LSEDF-TVAASNVIITLVF-------GKEY--DKSSSEL 3A4 PIIAQYGDVLVRNLRRE-AETGKPVT------LKDVF-GAYSMDVITSTSF-------GVNI--DSLNNPQ 3A5 PIIAQYGDVLVRNLRRE-AEKGKPVT------LKDIF-GAYSMDVITGTSF-------GVNI--DSLNNPQ 3A7 PIIAQYGDVLVRNLRRE-AETGKPVT------LKHVF-GAYSMDVITSTSF-------GVSI--DSLNNPQ 3A43 PIISQCGDMLVRSLRQE-AENSKSINL-----KEDFF-GAYTMDVITGTLF-------GVNL--DSLNNPQ 3A47 600 MKRQSSKLTSSLEPK---AENEEIIS------IKDFF-GAYNMNVATGVLF-------GMEM--E---P-- 3B1 2213aVARYADRITKKLEQ----SNLDEPIN------VKEFL-APYSLDAVTSVSF-------SVEA--DSIN--- 3B2 2213bIARYADRFIAKLEQ----TKLEDSTD------IKKLF-GPYSLDVIASSSF-------SVDA--DSIN--- 3A48 MLQHSKNLLNFLNKKVE-ADEVID--------VKDVF-GPYSMDVVTSTAF-------SVDI--DSIN--- 3A49 MLQHSKNLLNFLHKKVE-ADEVID--------VKDVF-GPYSMDVVTSTAF-------SADI--DSIN--- 3A50P MLQHSNILM-----------------------------------------F-------SIDI--ESLN--- 3A27 troutMKQHSSTLLSGMKKQAD-KDQTIE--------VKEFF-GPYSMDVVTSTAF-------SVDI--DSLNNPS 5A1 PLISQACDLLLAHLKRY-AESGDAFD------IQRCY-CNYTTDVVASVPF-------GTPV--DSWQAPE 5A1 1244 PLINTATDALIKNLDAF-AESAEAFN------IHKCF-GCFTMDVVASVAF-------GTQV--DSQN--- 4A11 GLMADSVRVMLDKWEELLGQDSP-------LEVFQHV-SLMTLDTIMKCAFSHQ----GSIQV-DRNSQSY 4A22 GLMADSVRVMLDKWEELLGQDSP-------LEVFQHV-SLMTLDTIMKSAFSHQ----GSIQV-DRNSQSY 4A20 TMMSESVRMMLNKWEEHIAQNSR-------LELFQHV-SLMTLDSIMKCAFSHQ----GSIQL-DRSSYLK 4B1 AVFTESTRIMLDKWEEKAREGKS-------FDIFCDV-GHMALNTLMKCTFGRG----DTGLG-HRDSSYY 4F2 KIFNESVNIMHAKWQLLASEGSA------CLDMFEHI-SLMTLDSLQKCVFSFD----SHCQE-KPSEYIA 4F3 KIFNESVNIMHAKWQLLASEGSA------RLDMFEHI-SLMTLDSLQKCVFSFD----SHCQE-KPSEYIA 4F8 KIFSKSANIMHAKWQRLAMEGST------CLDVFEHI-SLMTLDSLQKCIFSFD----SNCQE-KPSEYIT 4F11 KIFNKSVNIMHDKWQRLASEGSA------RLDMFEHI-SLMTLDSLQKCVFSFE----SNCQE-KPSEYIA 4F12 TIFNKSANIMLDKWQHLASEGSS------CLDMFEHI-SLMTLDSLQKCIFSFD----SHCQE-RPSEYIA 4F22 KIFNQSADIMHAKWRHLAEGSAV------SLDMFEHI-SLMTLDSLQKCVFSYN----SNCQE-KMSDYIS 4F28 2425 TKFNTSTNTLHDKWHRLLVEGTT------NIEVFEHF-TLMTLDSLLKCAFSYD----SDCQQ-SSSEYAS 4X1 EVMAHSVKMMLDKWEKICSTQDT------SVEVYEHI-NSMSLDIIMKCAFSKE----TNCQT-NSTHDPY 4V2 DIMNEQANILVKKLEKHINQEAF--------NCFFYI-TLCALDIICETAMGKN----IGAQS-NDDSEYV 4V5 485 EVMNEQAEILVEKLDQQAGKGPF--------NCFSYV-TLCALDIICETAMGKK----IYAQS-NSESEYV 4T5 8637 KLMAHSTKTMLDKWESYAKTNKP-------LEVFEYV-SLMTLDTILNCAFSYD----SNCQT-ERKNTYI 4T2seabassKLMSDSTKTMLDKWGSYANSNES-------FELFQHV-SLMTLDSILKCAFSYN----SNCQTESGTNVYI 46 ETFNEKAEQLVEILEAK---------------ADGQT-PVSMQDMLTYTAMDIL----AKAAF-GMETSML 46 4537 GNFNETADKLMDKLSEI---------------ADNKT-TANMLHLVNCVTMEVL----AKVAF-GVDLDLL 20 LLLKLSEELLDKWLSYPE------------TQHVPLS-QHMLGFAMKSVTQMVM----GSTF---EDDQEV 20 486 NFPLLVDELVGKWKSFPE------------DQHTPLC-AHQLVLAMKTITQLAL----GESF---SEDARV 26A1 PVITEEVGSSLEQWLSCGERG---------LLVYPEV-KRLM-FRIAMRILL------GCEP---QLAGDG 26A1 12575PAMQHEVQAAVQEWLAKDSC----------VLVYPEM-KRLM-FRIAMQILL------GFQL---EQIKTD 26B1 4267 PKIQQVIQESLRVWSSNPEP----------INVYRES-QRLS-FTMAVRVLL------GFRV---SEEEMK 26C1 11741PRLQEVIKCEIAKWCAEPGS----------VDVYAAT-RSLT-FRIAIGVLL------GLHL---EEERID 26B1 PKIQLVIQDTLRAWSSHPEA----------INVYQEA-QKLT-FRMAIRVLL------GFSI---PEEDLG 26C1 PRLQGALRHEVRSWCAAGGP----------VSVYDAS-KALT-FRMAARILL------GLRL---DEAQCA 11A1 DAVSRDFVSVLHRRIKKAGSGNYS------GDISDDL-FRFA-FESITNVIF------GERQ---GMLEEV 11A1 1630 DEVGNDFVVRVHKKIARSGQNKWT------TDLSQEL-FKYA-LESVSSVLY------GERL---GLFLDY 11B1 DAVARDFSQALKKKVLQN----ARGSLT--LDVQPSI-FHYT-IEASNLALF------GERL---GLVGHS 11B2 DAVARDFSQALKKKVLQN----ARGSLT--LDVQPSI-FHYT-IEASNLALF------GERL---GLVGHS 11B1 fugu DEVAQDCHMMQTKVEREGRGERGKRSLT--INPSPDL-FRFALEFASCHVLY------GERI---GLFSSS 27A1 NEVIDDFMTRLDQLRAESASGNQV------SDMAQLF-YYFA-LEAICYILF------EKRI---GCLQRS 27A1 3437 GEVVTDFIRRIYFLRQRSPTGDVV------TDLNNEL-YHFS-LEAIASILF------ETRL---GCLEEE 27A2 697 ------------------------------SREVDGD------LLGISAILF------ETRL---GCLGEK 27A3 NDVVTDFLEKLVWLRAKDGGGVMV------NDVAGEL-YKFA-FEGISSVLF------ESRM---GCLNDE 27B1 NNVVCDLVRRLRRQRGRGTGPPAL------VRDVAGE-FYKFGLEGIAAVLL------GSRL---GCLEAQ 27B1 470 QTLNSVVDDLITKLRLRRSSQGL-------VTDIASE-FYRFGLEGVSSVLF------ESRI---GCLDKI 27C1 NQVIADLIKRIYLLRSQAEDGETV------TNVNDLF-FKYS-MEGVATILY------ESRL---GCLENS 27C1 1410 DEVVDDLIKRIVCLRSQSSDGTTI------CNINDLF-FKYA-MEGIAAILY------ECRL---GCLSQK 24 NEVLADFMGRIDELCDERGHV---------EDLYSEL-NKWS-FESICLVLY------EKRF---GLLQKN 24 1804 NEVLEDFVSRIGKTNIG-GKI---------EDLYFEL-NKWS-FESICLVLY------DKRF---GLLQDK 19 TV----------CAESL-KTHLDRLE-------EVTN-ESGYVDVLTLLRRVMLD---TSNT--LFLRIPL 19ov 7098 EV----------CNSST-QAHLDRLE-------DLAQ-----VDVLSLLRCTVVD---ISNR--LFLDIPI 19br 4200 GV----------CVTST-AKHLDCLV-------DMTD-ASGHVDALNLLRAIVVD---ISNR--LFLRVPL 8A1 EAM--YTNLHAVLLGDATEAGS----------GWHEM-GLL-DFSYSFLL----------RA--GYLTLYG 8A2 5061 GTM--KANIESLLLSDVKGGSAS---------GWRQD-GLF-NFCYSLLF----------RA--GYLTLFD 8A1 4451 SSM--SRHMLEVAKAEMPQNQK----------DWKED-GLF-NLSYSLLF----------KV--GYLTLFG 8B1 ETM--LDSLSFVMLTSKGWSLDA--------SCWHED-SLF-RFCYYILF----------TA--GYLSLFG 8B1 7782 QAMMVNLQNLMLHNVDSSSDQVT----------WREE-KLF-AYCYNIVF----------RA--GYLSLYG 8B2 21917QAMMINLQNLMLHNVDSSSDRVT----------WREE-KLF-AYCYNIVF----------RA--GYLSLYG 7B1 ESMMQNLKQVFEPQLL---KTT----------SWDTA-ELY-PFCSSIIF----------EI--TFTTIYG 7A1 ESMMENLQRIMRPPVSSNSKTA----------AWVTE-GMY-SFCYRVMF----------EA--GYLTIFG 7A1 5172 KTMMGHLQDVMLKSDTLRRSKD----------HWEVD-GIF-AFCYKVMF----------ES--GYLTLFG 7C1 16085EGMMGNLMMLLRQDHLGRRPGAGP--------GWKSG-DMY-EFCSRVMF----------EA--TFLTLYG 39A1 EELHEQLENLGTHGTMDLNNLV----------RHLLY-PVT-VNMLFNKS----------LF-STNKKKIK 51 SIIEKETKEYFESW--GESGE---------KNVFEAL-SELIILTASHCLH-------GKEI--------- 51 437 KIIEAETREYFQRW--GDSGE---------RDLFEAL-SELIILTASSCLH-------GKEI--------- 2C9 LNLMEKLNENIK----------ILSSPWIQI-CNNFSPIIDY----FPGTH------------------- 2C19 LNLMEKLNENIR----------IVSTPWIQI-CNNFPTIIDY----FPGTH------------------- 2C18 LNLMEKFNENLR----------ILSSPWIQV-CNNFPALIDY----LPGSH------------------- 2C8 LTLMKRFNENFR----------ILNSPWIQV-CNNFPLLIDC----FPGTH------------------- 2E1 LRLMYLFNENFH----------LLSTPWLQL-YNNFPSFLHY----LPGSH------------------- 2F1 LTIIRLINDNFQ----------IMSSPWGEL-YDIFPSLLDW----VPGPH------------------- 2W1 VSLLGLIDEVMV----------LLGSPGLQL-FNVHPWLGAL----LQLHR------------------- 2B6 LKMLNLFYQTFS----------LISSVFGQL-FELFSGFLKY----FPGAH------------------- 2A6 LSLLRMMLGIFQ----------FTSTSTGQL-YEMFSSVMKH----LPGPQ------------------- 2A7 LSLLSMMLGIFQ----------FTSTSTGQL-YEMFSSVMKH----LPGPQ------------------- 2A13 LSLLRMMLGRFQ----------FTGTSTGQL-YEMFSSVMKH----LPGPQ------------------- 2G1P ---------------------------------------------------------------------- 2G2P LNLLRLINESFI----------EMSTPWAQL-YDMYSGIMQY----LPGRH------------------- 2M1 troutQLIQKAVDAYFN----------VLSSPIGAM-YNMFPRIVWC----FPGNH------------------- 2J2 QQLLKLLDEVTY----------LEASKTCQL-YNVFPWIMKF----LPGPH------------------- 2X2 4007REIVRCFTENAK----------ISNGPWAML-YDSIP-LVRY----LPLPF------------------- 2X3 KFFTNFFRETSQ----------IINGPWSLL-YDSFP-AVRY----LPLPF------------------- 2X1catfishKVYVRLYSENAK----------LANGTWSII-YDALP-ILRS----LPLPF------------------- 2V1 DanioLNMLSLISKALK----------LQTSVFIQL-YAAFPRLMDL----LPGPH------------------- 2Z2 2993bKNLIKLFDQSLQ----------IEASVWAEL-YNSFPLLMKH----VPGPH------------------- 2P3 killiQTILQYFNEAVR----------LQGDLSVQI-YNSIPGLMRW----LPGSH------------------- 2P4 ------------------------------V-YNTFPWLLKW----LPGTH------------------- 2N2 killiQMMLRCMSEAVL----------LEGNVWGQL-YMAFPSVMRY----MPGPH------------------- 2N11 3261cQMLLKYLSELLV----------LEGSFWGQL-YQAFPSVMKH----LPGPH------------------- 2N10 3261bQMLLKYLSEVLV----------LEGSFWGQL-YEAFPSVMKH----LPGPH------------------- 2N12 3261dRRILELDNEAVV----------LAGSARTQL-YDSFPSLMKH----LPGPH------------------- 2N9 3261aQRMLHHLTEMAY----------LEGSIWALL-YDSFPALMKH----LPGPH------------------- 2Y2 39b LELLRVIAEVLR----------FNSSFLGQM-YNVFPWILEH----LPGPQ------------------- 2R1 7138 QHMIELFSENVE----------LAVSGWALL-YNAFPWIEYL----PFGKH------------------- 2U1 8899 RSMLRLMDRGLE----------ICVNSPAVL-INVFPLLYHL----PFGVF------------------- 2U1 KKMLGFMSRGLE----------ICLNSQVLL-VNICPWLYYL----PFGPF------------------- 2Z1 2993aEKLMNSFGRCLQ----------IEASVCAQL-YNSFPRLMGC----LPGPH------------------- 2K9 12487QAMIERDHEVIH----------LTGSPSIQI-YNIFPWLGPF----LKTWR------------------- 2K6 DanioHRMVGRAYENMK----------LTGSPSVQI-YNMFPWLRPI----VANRN------------------- 2Y1 39a LSLLHIISETIQ----------FGSSASGLM-YNLFPRLMEW----LPGRH------------------- 2K10 19693INMVNRVNEVIR----------LTGSAPIQL-YNIFPGLANW----IKNRQ------------------- 2K11 TSLVDRTNTLIQ----------ISGSPSVLV-YDLFPWIGPL----VNNKK------------------- 2R1 QHMIELFSENVE----------LAASASVFL-YNAFPWIGIL----PFGKH------------------- 2S1 QAVVRAAGGTLL----------GVSSQGGQT-YEMFSWFLRP----LPGPH------------------- 2T2P LRLLNLFSDNFC----------------IIS-SRWGESLMDW----LPGPH------------------- 2D6 LRLLDLAQEGLK----------EESGFLREV-LNAVPVLLH-----IPALA------------------- 1A1 LSLVNL-NNNFG----------EVVG-SGNP-ADFIPILRY-----LPNPS------------------- 1A2 LSLVKN-THEFV----------ETAS-SGNP-LDFFPILRY-----LPNPA------------------- 1B1 RELLSH-NEEFG----------RTVG-AGSL-VDVMPWLQY-----FPNPVRTV---------------- 1B2 3008aRDVLRR-IDKFG----------QTVG-AGSL-VDVMPWLQS-----FPNPVRSM---------------- 1B3 3008bRCLLKK-LNKFG----------ETVG-AGSL-VDVMPWLQS-----FPNPVRSL---------------- 1B1 1553 QQVVGR-NDQFT----------RTVG-AGSI-VDVMPWLQY-----FPNPVKSI---------------- 17 NVIQNY-NEGII----------DNLS-KDSL-VDLVPWLKI-----FPNKT------------------- 17A1 4175 EAMLHY-SQGIV----------DTVA-KDSL-VDIFPCLQI-----FPNAD------------------- 17A2 8086 QEVLRY-NDGIV----------QTIA-GGGL-VDIYPWMKV-----FPNKT------------------- 21 PAYYKCIQEVLK----------TWSH-WSIQIVDVIPFLRF-----FPNPG------------------- 21 15 QQLHRCLNEIVA----------LWGS-TWISALDTFPLLRK-----FPNPVF------------------ 3A4 DPFVENTKKLLR----------FDFLDPFFLSI-IFPFL-------IPILE------------------- 3A5 DPFVESTKKFLK----------FGFLDPLFLSIILFPFL-------TPVFE------------------- 3A7 DPFVENTKKLLR----------FNPLDPFVLSIKVFPFL-------TPILE------------------- 3A43 DPFLKNMKKLLK----------LDFLDPFLLLISLFPFL-------TPVFE------------------- 3A47 600 SLPIKHASKLFKFP--------IPLFMIQGASPRCFPIL-------LPLLQ------------------- 3B1 NPNDPLIVNLKKV---------FKFNFVVFFLVAFFPFC----------AR------------------- 3B2 NPDDPFIINIKKV---------LNLNFWLLLIKNVLPFS----------SY------------------- 3A48 NPSDPFVANIKEM---------TQFSFLNPLVVLFPFLV--------PIFK------------------- 3A49 HPSDPFVANIKKM---------VKFNFLNPLLIFVVLFPFT-----QPIFD------------------- 3A50P NPSSPFLHYLQEV---------SKYNYMNLWRLLGAIFPFL-----TPLMD------------------- 3A27 troutHPSDPFVANIKKMVK-------FNFLNPLLIFVVLFPFT-------QPIFD------------------- 5A1 DPFVKHCKRFFE----------FCIPRPILVLLLSFPSI-------MVPLA------------------- 5A1 1244 NCDDPFVRHAQLFFS-------FNFFRPIMLFFAAFPSL-------AAPLV------------------- 4A11 IQAISDLNNLVFSRV-------RNAFHQNDTIYSLTSA-GRW----THRA-------------------- 4A22 IQAISDLNSLVFCCM-------RNAFHENDTIYSLTSA-GRW----THRA-------------------- 4A20 --AVFNLSKISNQRM-------NNFLHHNDLVFKFSSQ-GQI----FSKF-------------------- 4B1 -LAVSDLTLLMQQRL-------VSFQYHNDFIYWLTPH-GRR----FLRA-------------------- 4F2 --AILELSALVSKRH-------HEILLHIDFLYYLTPD-GQR----FRRA-------------------- 4F3 --AILELSALVTKRH-------QQILLYIDFLYYLTPD-GQR----FRRA-------------------- 4F8 --AIMELSALVVKRN-------NQFFRYKDFLYFLTPC-GRR----FHRA-------------------- 4F11 --AILELSAFVEKRN-------QQILLHTDFLYYLTPD-GQR----FRRA-------------------- 4F12 --TILELSALVEKRS-------QHILQHMDFLYYLSHD-GRR----FHRA-------------------- 4F22 --AIIELSALSVRRQ-------YRLHHYLDFIYYRSAD-GRR----FRQA-------------------- 4F28 2425 --AIIELSDLIIERR-------QRILHHWDWIYWRTQQ-GKR----FKKA-------------------- 4X1 AKAIFELSKIIFHRL-------YSLLYHSDIIFKLSPQ-GYR----FQKL-------------------- 4V2 -RAVYRMSEMIFRRI-------KMPWLWLDLWYLMFKE-GWE----HKKS-------------------- 4V5 485 -KCVSKMSDIISRRQ-------RTPWFWPNFAYYSIGD-GRE----HDST-------------------- 4T5 8637 -KAVYELSNLINLRF-------RIFPYHNDLIFYLSPH-GFR----YRKA-------------------- 4T2seabass-KAVYELSDLINLRL-------RTFPYHSDLIFYLSPH-GYR----YRKA-------------------- 46 -LGAQKPLSQAVKLM-------LEGITASRNTLAKFLP-GKR----KQLREVRES--------------- 46 4537 -RKSSPFPRAVELCL-------KGMVFSIRDTFFMLNP-KNW----SFIREVRGA--------------- 20 -IIRFQKNHGTVWSE-------IGKGFLDGSLDKNMTR-KKQ----YEDA-------------------- 20 486 -DAFRKNHDVVIWSE-------IGKGYMDGSLEKSTSR-KGH----YEKGA------------------- 26A1 --SEQQLVEA------------FEEMTRNLFSLPIDVP-FSG----LYRGMKARNL-------------- 26A1 12575---EQKLVEA------------FEEMIKNLFSLPIDMP-FSG----LYRG-------------------- 26B1 4267 -----HLFST------------FQDFVDNLFSLPIDLP-FSG----YRKG-------------------- 26C1 11741-----YLAQI------------FGQLMSNLFSLPIDAP-FSG----LRKG-------------------- 26B1 -----HLFEV------------YQQFVDNVFSLPVDLP-FSG----YRRG-------------------- 26C1 -----TLART------------FEQLVENLFSLPLDVP-FSG----LRKG-------------------- 11A1 VNPEAQRFIDAI----------YQMFHTSVPMLNLPPDLFRL----FR---------------------- 11A1 1630 IDPEAQHFIDCI----------SLMFKTTSPMLYIPPALLRK----VG---------------------- 11B1 PSSASLNFLHAL----------EVMFKSTVQLMFMPRSLSRW----TS---------------------- 11B2 PSSASLNFLHAL----------EVMFKSTVQLMFMPRSLSRW----IS---------------------- 11B1 fugu PSLESQKFIWAV----------ERMLATTPPLLYLPHRLLLH----LG---------------------- 27A1 IPEDTVTFVRSI----------GLMFQNSLYATFLPKWTRPV---------------------------- 27A1 3437 IPTGTQDFINAI----------SQMFSNNFQVFLMPKWSRGV---------------------------- 27A2 697 VDPNVQRFISGV----------NDMLSLSDITYLFPRWTRSF---------------------------- 27A3 VPEETQKFIYSV----------GEMFRLSAVVVLFPQSVWPY---------------------------- 27B1 VPPDTETFIRAV----------GSVFVSTLLTMAMPHWLRHL----V----------------------- 27B1 470 VPEETERFIQCI----------NTMFVMTLLTMAMPSWMHQL----F----------------------- 27C1 IPQLTVEYIEAL-------ELMFSMFKTSMYAGAIPRWLRPF----I----------------------- 27C1 1410 IPQETEDYIDAL-------HLMFSSFKTTMYAGAIPKWLRPV----F----------------------- 24 AGDEAVNFIMAI----------KTMMSTFGRMMVTPVELHKS----LN---------------------- 24 1804 VNEEAMNFITAV----------KTMMSTFGLMMVTPVELHKS----LN---------------------- 19 DESAIVVKIQGY----------FDAWQALLIKPDIF---FKI---------------------------- 19ov 7098 NEKELLLKIHKY----------FDTWQTVLIKPDIY---FKF---------------------------- 19br 4200 NEKDLLTKIHNY----------FETWQAVLIKPDIF---FKI---------------------------- 8A1 IEALPRTHESQAQDRVH-----SADVFHTFRQLDRL---LPK----LARGSLSV---------------- 8A2 5061 SADN------------------VTAIYKEFRKFDKL---LSK----LVRGSLKK---------------- 8A1 4451 GEQNNNCSD-------------LASIYEEYKKFDGL---LTK----MARGTLKS---------------- 8B1 YTKDKEQDLLQAGELFM-----EFRKFDLLFPRFVY---SLL----WPREWLEV---------------- 8B1 7782 QEKAKEKDRAESEALYH-----EFRKYDQLFPRLAY---GVL----PPKKQREA---------------- 8B2 21917QEKAKEKDRAESEALYH-----EFRKYDQLFPRLAY---GVL----PPKKRREA---------------- 7B1 KVIVCDNNKFI-----------SELRDDFLK-FDDK---FAY----LVSNIP------------------ 7A1 RDLTRRDTQKAH----------ILNNLDNFKQFDKV---FPA----LVAGLP------------------ 7A1 5172 KELARQAAQKAL----------VLNALENFKEFDKI---FPA----LVAGLP------------------ 7C1 16085IPQEGGRHDG------------MDELRKDLFQFDGW---FPW----LVAGVP------------------ 39A1 EFHQYFQVYDED----------FEYGSQLPECLLR----------------------------------- 51 RSQLNEKVAQLY----------ADLDGGFSHAAWLLPGW-------LP---------------------- 51 437 RSMLDERVAQLY----------ADLDGGFTHAAWLLPGW-------LP---------------------- 2C9 ---NKLLKNVAFMKSYILEKVKEHQESMDMNNPQD------FIDCFLM-KMEKEK--HNQPSE----FTIESL 2C19 ---NKLLKNLAFMESDILEKVKEHQESMDINNPQD------FIDCFLI-KMEKEK--QNQQSE----FTIESL 2C18 ---NKIAENFAYIKSYVLERIKEHQESLDMNSARD------FIDCFLI-KMEQEK--HNQQSE----FTVESL 2C8 ---NKVLKNVALTRSYIREKVKEHQASLDVNNPRD------FIDCFLI-KMEQEK--DNQKSE----FNIENL 2E1 ---RKVIKNVAEVKEYVSERVKEHHQSLDPNCPRD------LTDCLLV-EMEKEK--HSAERL----YTMDGI 2F1 ---QRIFQNFKCLRDLIAHSVHDHQASLDPRSPRD------FIQCFLT-KMAEEK--EDPLSH----FHMDTL 2W1 ---PVLRKIEEVRAILRTLLEARRPHVCPGDPVCS------YVDALIQ-QGQGDD--PEGL------FAEANA 2B6 ---RQVYKNLQEINAYIGHSVEKHRETLDPSAPKD------LIDTYLL-HMEKEK--SNAHSE----FSHQNL 2A6 ---QQAFQLLQGLENFIAKKVEHNQRTLDPNSPRD------FIDSFLI-RMQEEE--KNPNTE----FYLKNL 2A7 ---QQAFKLLQGLENFIAKKVEHNQRTLDPNSPQD------FIDSFLI-HMQEEE--KNPNTE----FYLKNL 2A13 ---QQAFKELQGLEDFIAKKVEHNQRTLDPNSPRD------FIDSFLI-RMQEEE--KNPNTE----FYLKNL 2G1P ------------------------------------------------------------------------- 2G2P ---NLIYYLVEELKDFIASRVKINEASFDPQNPRD------FIDCFLI-KMHQDK--NNPRTE----FNLKNL 2M1 trout---HEMFAIVNKAKVYIQEQAEIRLKTLNISEPQD------FIEAFLV-KMLEEK--DDPNTE----FNNGNM 2J2 ---QTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD------FIDAYLK-EMSKHT--GNPTSS----FHEENL 2X2 4007---KNAFKNVETAENLVKDLFVEHKKTRMSGDPRD------FVDCYFD-ELDKR---GKDRSS----FSENML 2X3 ---KRGFEMFKMSHERYLEMFVETKKTRVPGKPRH------FVDAYMD-ELEKR---GDEAF-----FSEDQL 2X1catfish---KKAFDNYSTLKILTANMINKHRTTRVPGKPRD------LVDCYLD-EIDKK---DNEST-----FSEEQL 2V1 Danio---KELFSCFHQVRAFIKEEVDKHRADWDPSSPRD------FIDCYLT-EIEKMK--DDLEAG----FHDEGL 2Z2 2993b---QTVKKIWNEVKDFVRNELKEHRKNWDPSDPRD------YIDCYLR-EIQAS---GQSDST----FDEENL 2P3 killi---KKIFMILQKLVDFVEIRIKEHRENLDPSSPRD------YIDSFLI-EMGEK---EDKDSG----FELSNL 2P4 ---QTIFSEIKTVINFVDLKIQEHKRNFDPSSLRD------YIDCFLA-EMGEK---EDVESG----FDMKNL 2N2 killi---NKIFSHFSSVEQFLYEEVEQHKKDLDRDNPRD------YIDTFLI-EMENH---KESDLG----FTEANL 2N11 3261c---NKVFSHYNHLKDFMNEEIQNHKKNLNHNNPRD------YIDAFII-EMEKNK---DTNLG----FTETNL 2N10 3261b---NKVFSHFNHLKDFMNEEIQNHKKDLDHNNPRD------YIDAFII-EMEKNK---DTNLG----FTETNL 2N12 3261d---QTVHANYGKITDFLKKEVDKHMEEWNPEDPRD------YVDTYLS-EMEKMN--QDPQGG----FNVETL 2N9 3261a---NGIFSSSSSLQGFIWREIQRHKSDLDPSNPRD------YIDAFLI-EEGNG----NNQLG----FEERNL 2Y2 39b ---HTMFSHVNFLREFIKKKIQEHKESLDPSSPRD------YIDTFLI-RMEQEK--NLPNTE----FHYENL 2R1 7138 ---QKLFFNAAEVYDFLLRVTKEFSQGRVPHMPRH------YVDAYLD-ELERNA--GDPNSS----FSYENL 2U1 8899 ---RELRQVERDITAFLKRFIANHQETLDPNNPRD------LTDMYLK-EISARREAGDVDSG----FTEDYL 2U1 ---KELRQIEKDITSFLKKIIKDHQESLDRENPQD------FIDMYLL-HMEEER-KNNSNSS----FDEEYL 2Z1 2993a---QTVKRIYQNIRDFIREEMKEHKKGLDPSTPRD------YIDCYLN-KIKKS----GAPHT----FHEENL 2K9 12487---YIMKKVEINIES-TRRIIGEMKETRNPGTCRC------FVDAFLI-HKENQEESDVNAHY----YHEDNL 2K6 Danio---QIVKNLRDTFKQ-NEELINGVMKTLDPFNPRG------IVDSFLI-RQQKDEESGKTDSL----YNSNNL 2Y1 39a ---REMFGKIEKVRAFTMEKIEEHQDTLDPSSPRD------YIDCFLM-RLQQEKP--QPNTE----FNYDNL 2K10 19693---LLLKQVAMNLRD-MTDLIQQLKDTLNPGVCRG------FVDCFLL-RKQKAVDSGVIDSL----YNEKNL 2K11 ---LFQSLFAANKKQ-NLQLFAAAKEMLNPQMCRS------FVDSFLA-RQQILEKSGTNVH-----FHDENL 2R1 ---QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH------FVDAYLD-EMDQGK--NDPSST----FSKENL 2S1 ---KQLLHHVSTLAAFTVRQVQQHQGNLDASGPARD-----LVDAFLL-KMAQEE--QNPGTE----FTNKNM 2T2P ---HRIFRNFSELRV-ISEQIQRHWQMRQPAEPRD------FIDCLTR-WVRHGQ--QDPESH----FQE*TS 2D6 ---GKVLRFQKAFLTQLDELLTEHRMTWDPQPPRD------LTEAFLA-EMEKAK--GNPESS----FNDENL 1A1 --LNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD------ITDSLIE-HCQEKQLDENANVQ----LSDEKI 1A2 --LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRD------ITGALFK-HSKKGP-RASGNL-----IPQEKI 1B1 --FREFEQLNRNFSNFILDKFLRHCESLRPGAPRD------MMDAFIL-SAEKKAAGDSHGGGAR--LDLENV 1B2 3008a--FRSFEALNREFFGFVQLKVEQHRETFDPEVTRD------MSDAIIS-VLEKSD--GETA------LTKDYT 1B3 3008b--YENFKSLNEEFFNFVKNKVQEHRESFDPNVTRD------MSDAMIN-VIEERK--DGT-------LSKEFA 1B1 1553 --FDNFKRLNKEFSDFIRDKVTEHRKSIRPSSVRD------MTDAFIV-SLDKLS--EKTGVP----LWKDYV 17 --LEKLKSHVKIRNDLLNKILENYKEKFRSDSITN------MLDTLMQ-AKMNSDNGNAGPDQDSELLSDNHI 17A1 4175 --LRLLKRCVSVRDKLLQKEYDKHKAAYSDHVQRD------LLDALLR-AKCSAENNNTTGINAESVLTDDHL 17A2 8086 --LSKLKACIAVRDRLLTHKLEEHKATLTDNQPRD------LLDALLM-GQVGRGRRKGSGRVEEDIITEDHV 21 --LRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRD------MMDYMLQ-GVAQPSMEEGSGQ-----LLEGHV 21 15 --SRLLREVSRRDEIIRKHLNQFKCVLCCAQSEGH------RRTDVIT-GSLLEGV-----------LTDMHV 3A4 --VLNICVFPREVTNFLRKSVKRMKESRLEDTQKH------RVD-FLQLMIDSQN-SKETESHKA--LSDLEL 3A5 --ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKH------RLD-FLQLMIDSQN-SKETESHKA--LSDLEL 3A7 --ALNITVFPRKVISFLTKSVKQIKEGRLKETQKH------RVD-FLQLMIDSQN-SKDSETHKA--LSDLEL 3A43 --ALNIGLFPKDVTHFLKNSIERMKESRLKDKQKH------RVD-FFQQMIDSQN-SKETKSHKA--LSDLEL 3A47 600 --LMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ-------EFD-FLQHMISTQKNDGIYAVTSG--LTDHEI 3B1 2213a--LFQFLGIDPIPRSSVNYFYNVIKNFKDQHHADT------RGD-FLQVLIQSEIPQSEIKSPKG--LTEHEI 3B2 2213b--LFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQSI------KGD-FLHVMIQNEIPQSEIKSPKG--LTEQEI 3A48 --KMNVSTFPAHVIDFFFNFLRQIKSDRNKDKKKS------RVD-FMQLMVNAQMQEGNEEGSSQKGLTDNEI 3A49 --KVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKKS------RVD-FMQLMVNAQMQEGNEEGSSQKGLTDNEI 3A50P --KMNITVNSSEALQFFISVIKKIKEERKNNPKD-------RVD-FMQLMLNAQAPDGSNKDCDSAGLSDEEI 3A27 trout--KMKFSFFPTAVTDFFYASLAKIKSGRDTGNSTN------RVD-FLQLMIDSQKGSDGEEQTKG--LTDHEI 5A1 --RILPNKNRDELNGFFNKLIRNVIALRDQQAAEE------RRD-FLQMVLDARHSASPMGVQDFD-LTVDEI 5A1 1244 --GIIPNRRRDFLQLMLDARTSDESVSIEHFDTAH-----PVGEAHNRSEQNQDNQVGPQERPQMKMITEDEI 4A11 --CQLAHQHTDQ--VIQLRKAQLQKEGELEKIKRKR-----HLD-FLDILLL--AKMENGSI-----LSDKDL 4A22 --CQLAHQHTDQ--VIQLRKAQLQKEGELEKIKRKR-----HLD-FLDILLL--AKMENGSI-----LSDKDL 4A20 --NQELHQFTHLEKVIQDRKESLKDKLKQDTTQKR------RWD-FLDILLS--AKVENTKD-----FSEADL 4B1 --CQVAHDHTDQ--VIRERKAALQDEKVRKKIQNRR-----HLD-FLDILLG--ARDEDDIK-----LSDADL 4F2 --CRLVHDFTDA--VIQERRRTLPSQGVDDFLQAKAKSK--TLD-FIDVLLL--SKDEDGKK-----LSDEDI 4F3 --CRLVHDFTDD--VIQERRRTLPSQGVDDFLQAKAKSK--TLD-FIDVLLL--SKDEDGKK-----LSDEDI 4F8 --CRLVHDFTDA--VIQERRRTLTSQGVDDFLQAKAKSK--TLD-FIDVLLL--SEDKNGKE-----LSDEDI 4F11 --CHLVHDFTDA--VIQERRRTLPTQGIDDFLKNKAKSK--TLD-FIDVLLL--SKDEDGKE-----LSDEDI 4F12 --CRLVHDFTDA--VIRERRRTLPTQGIDDFFKDKAKSK--TLD-FIDVLLL--SKDEDGKA-----LSDEDI 4F22 --CDMVHHFTTE--VIQERRRALRQQGAEAWLKAK-QGK--TLD-FIDVLLL--ARDEDGKE-----LSDEDI 4F28 2425 --LSIVHKFTRD--VVQKRLALISQKGVAELAAHR------KRD-FVDIILL--TKDEDGKG-----LTDEEL 4X1 --SRVLNQYTDT--IIQERKKSLQAGVKQDNTPKRK-----YQD-FLDIVLS--AKDESGSS-----FSDIDV 4V2 --LQILHTFTNS--VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLS--VTDDEGNR-----LSHEDI 4V5 485 --LKVLHSFTYK--VITERAENVSSVESDSDSDHGR----KKRQAFLDMLLK--TTDEDGNK-----MSHRDI 4T5 8637 --CMVAHSHTEE--VIKKRREALKKEKELERIQAKR-----NLD-FLDILLF--AKDENQQG-----LLDEDI 4T2seabass--IKVAQSHTEE--VIKKRKEALKEEKELDRIQAKK-----NLD-FLNILLL--ARDEKQQG-----LSDEDI 46 --IRFLRQVGRD--WVQRRREALKRGEEV----------------PADILTQ--ILKAEEGA-----QDDEGL 46 4537 --CRLLRQTGAQ--WIQQRKTAMRNGEV-----------------PKDILTQ--IIKSAGKE-----EDEEFM 20 --LMQLESVLRN--IIKERKGRNFSQHI-----------------FIDSLVQ--GN-----------LNDQQI 20 486 --LSEMESTLLS--VVKERKSQRNKSV------------------FVDSLIQ--ST-----------LTERQI 26A1 --IHARIEQNIR--AKICGLRASEAGQG-------------CKD-ALQLLIE--HSWERGER-----LDMQAL 26A1 12575--LKARNFIHAK--IEENIKRKLRESNSDSK----------CRD-ALQQLID--SSKKSGQV-----LSMQVL 26B1 4267 --IRARDTLQKS--IEKAIREKPLCSQGKD-----------YSD-ALDVLME--SAKENGSE-----LTMQEL 26C1 11741--IKARKILHAN--MEKIIEKKMERQQEEEE----------YRD-AFDYMLS--TSKEQGQQ-----ISIQEL 26B1 --IQARQILQKG--LEKAIREKLQCTQGKD-----------YLD-ALDLLIE--SSKEHGKE-----MTMQEL 26C1 --IRARDQLHRH--LEGAISEKLHEDKAAE-----------PGD-ALDLIIH--SARELGHE-----PSMQEL 11A1 --TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHD----YRGMLYRL--LGDSK--------MSFEDI 11A1 1630 --AKVWRDHVEAWDGIFNQADRCIQNIYRRLRQETGPSKK----YPGVLASL--LLRDK--------LSIEDI 11B1 --PKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-SRPQQ-----YTSIVAEL--LLNAE--------LSPDAI 11B2 --PKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-NRPQH-----YTGIVAEL--LLKAE--------LSLEAI 11B1 fugu --APLWWDHIFTHAEERIQRGYQRLSHSQSRGP-EGGGR-----YKGVLGQL--MAKGQ--------LSLELI 27A1 --LPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPD----GIQVSGY--LHFLLASGQ----LSPREA 27A1 3437 --LPYWRRYVAGWDGIFSFATRLIDRKMEFIQQHLDN-------NQNVEGEY--LTYLLSNTQ----MSIKDV 27A2 697 --VPVWKRFAQAWDDISDVASSLIDRRIAEIDARVAN-------GQSVEGLY--LTYLLSSDK----MSRAEI 27A3 --LPLWKKFVAAWDYLFKVAEQMVQKKMEEIQNKVDL-------HQDVEGAY--LTHLLLSEK----MTVTEI 27B1 --PGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEK---DLESGAHL--THFLFREE-----LPAQSI 27B1 470 --PKPWNVFCQCWDYMFDFAKGHIDQRMAAEAEKIARG------EEVEGRYL--TYFLSRTS-----LPMKTV 27C1 --PKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRG------RRVSGGLL--TYLFLSQA-----LTLQEI 27C1 1410 --PKPWEEFCDSWDGLFRFS-VHVDKRLKQIESQLQRG------EKVTGGLL--TYMLVAKE-----MSVEEI 24 --TKVWQGHTLAWDTIFKSVKACIDNRLE---------KYS----QQPSADF--LCDIYHQNR----LSKKEL 24 1804 --TKTWQDHTAAWDRIFSTAKVYIDKKLK---------RNS----VIAPDDL--IGDILHQSR----LSKKEL 19 --SWLYKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMD---FATELIL--AEKRGD-------LTRENV 19ov 7098 --GWIHQKHKTAARELQEAIEGLVEQKRRDLEQADKLENIN----FTAELLF--AQNHGE-------LSAENV 19br 4200 --GWLFDKHRRAAQELQDTMAALLKVKRKLVHEAEKLDDVLD---FATELIL--AQEAGE-------FSADNV 8A1 ---GDKDHMCSVKSRLWKLLSPARLARRAHRSKW----LESY---LLHLEEMG--------------VSEEMQ 8A2 5061 ---GETHTVNSSRKRLWELLSADWLSRASGSISW----QQSY---NRFLEKEG--------------VDMEMQ 8A1 4451 ---YEKKTAQSARQRLWELLAPARLAKGSGSTPW----LHAY---RRLLREEG--------------VDNEMQ 8B1 ---GRLQHLFHKMLSVSHSQEKEGISNWLGNMLQ-----------FLREQG----------------VPSAMQ 8B1 7782 ---TKLLEYFWNVLSVQKLKGRDNISRWIWDVQE-----------GKDNAG----------------VKEDMI 8B2 21917---TKLLEYFWNVLSVQKLKGRDNISRWIWDVQE-----------GKDNAG----------------VKEDMI 7B1 --IELLGNVKSIREKIIKCFSSEKLAKMQGWSEV----FQSR---QDVLEKYYV-------------HEDLEI 7A1 --IHMFRTAHNAREKLAESLRHENLQKRESISEL----ISLR---MFLNDTLST-------------FDDLEK 7A1 5172 --IHVFKSAYSARENLAKTMHAEKLSKRENVSDL----ISMR---MILNDSLST-------------FNDVSK 7C1 16085--IGLLRQAKTSRNKLTRSLLPMRISSWSNRSQF----IRRR---QELVEKVDA-------------LKDVDR 39A1 --NWSKSKKWFLELFEKNIPDIKACKSAKDNSMT-----------LLQATL--DIVETE--------TSKENS 51 --LPSFRRRDRAHREIKDIFYKAIQKRRQSQ-EK----IDD----ILQTLL--DATYKDGRP-----LTDDEV 51 437 --LPSFRKRDRAHREIKKIFFKVIEKRRRSG-EN----TDD----ILQTLV--DATYKDGRP-----LSDDEI 2C9 ENTAVDL---FGAGTETTSTTLRYALLLLLKH-PEVTAKVQEEIERVIG----RNR-------SPCMQDRSHM 2C19 VITAADL---LGAGTESTSTTLRYALLLLLKH-PEVTAKVQEEIERVIG----RNR-------SPCMQDRGHM 2C18 IATVTDM---FGAGTETTSTTLRYGLLLLLKY-PEVTAKVQEEIECVVG----RNR-------SPCMQDRSHM 2C8 VGTVADL---FVAGTETTSTTLRYGLLLLLKH-PEVTAKVQEEIDHVIG----RHR-------SPCMQDRSHM 2E1 TVTVADL---FFAGTETTSTTLRYGLLILMKY-PEIEEKLHEEIDRVIG----PSR-------IPAIKDRQEM 2F1 LMTTHNL---LFGGTKTVSTTLHHAFLALMKY-PKVQARVQEEIDLVVG----RAR-------LPALKDRAAM 2W1 VACTLDM---VMAGTETTSATLQWAALLMGRH-PDVQGRVQEELDRVLG----PGR-------TPRLEDQQAL 2B6 NLNTLSL---FFAGTETTSTTLRYGFLLMLKY-PHVAERVYREIEQVIG----PHR-------PPELHDRAKM 2A6 VMTTLNL---FIGGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRAKM 2A7 MMSTLNL---FIAGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRTKM 2A13 VMTTLNL---FFAGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRAKM 2G1P -------------------------------------AKIHEEINQVIG----PHR-------LPRVDDRVKM 2G2P VLTTLNL---FFAGTETVSSTLRYGFLLLMKH-PEVEAKIHEEINQVIG----PHR-------LPRVDDRVKM 2M1 troutVMTAWSL---FAAGTETTSSTLRQSFLMMIKY-PHIQESVQKEIDEVIG-----SR-------VPTVDDRVKM 2J2 ICSTLDL---FFAGTETTSTTLRWALLYMALY-PEIQEKVQVEIDRVIG----QGQ-------QPSTAARESM 2X2 4007TMYALDL---HFAGTDTTSNTLLTGFLYLMNY-PHIQERCHQEIDKVLQ----DNE-------TVTYDARNQM 2X3 CAIILDL---HFAGTDTTANTLLSGLLYLMKY-PHIQEYCQQEIDKVMQ----GKN-------EVSFEDRVQM 2X1catfishVVYIMNL---HIAGTDTTSNTLLTSILYLMAH-PDIQKRCQKEIDVVLE----GNS-------QPSFEDRHNM 2V1 DanioQYAVLDL---FVAGTETTSTTLLWAFVYMMKY-QKS-KKVQAEIDKVVG----RYR-------RPSMDDRPCM 2Z2 2993bVICVMDL---FVPGSETTSTTLRWAFLYMAKY-PEIQEKVQAEIDRVVG----QSR-------PLTMDDRVNL 2P3 killiCACTLDL---FGAGTETTTTTLHWGLLYMIYY-PQIQERVQAEIDAVIG----PSR-------QPSVADRENM 2P4 SICTMDL---FGAGTETTTTTLQWGLLYMIYY-PHIQEKVYAEISAVIG----SSR-------EPSITDRDNM 2N2 killiVYCAIDL---FLAGTETTATTLLWALVFLVKY-PEVQEKVQAEIDSVIE----QAR-------LPSMADRSSM 2N11 3261cVLCSLDL---FLAGTQTTATTLLWALVYLINN-PDIQEKVQAEIDQVIG----QTR-------QPTMADRPNL 2N10 3261bAMCSLDL---FIAGTETTATTLLWDLVYLINN-PDIQGKVQAEIDQVIG----QNR-------QPTMADRPNL 2N12 3261dLICILDL---IEAGTESAATTLRWGLVFILNY-PDVQEKVQEEIDRVIG----QSR-------QPAMADRPNM 2N9 3261aVLCCLDL---FLAGSETTSKTLQWGLIYLIRK-PHIQEKVQVEIDRPIG----RTR-------QPTMADRPNL 2Y2 39b VSTVLNL---FLAGTETTSSTLRYALGVLIKH-PNVQEEMQREIDNVVR----QDQ-------CPKMEDRKSL 2R1 7138 IYSVGEL---IIAGTETTTNTLRWAMLYMALY-PNIQGRVHREIDSVLA----NGR-------MPTLEDKQKM 2U1 8899 FYIIGDL---FIAGTDTTANSVLWVILYMASY-PDIQ-KVQAEIDGVVG----PLR-------TPSLSDKGKL 2U1 FYIIGDL---FIAGTDTTTNSLLWCLLYMSLN-PDVQ-KVHEEIERVIG----ANR-------APSLTDKAQM 2Z1 2993aVICVWDL---FLAGTDTTTSTLHWLFLFMAKY-PEMQEKVQAEIDEVIG----QSR-------RATMDDCVNM 2K9 12487LHCAMNL---FGAGTDTTATTLQWGLLYITKY-PHIQDGVQEELRRVVG-----NR-------QVRVEDRKNL 2K6 DanioYCTVNNL---FGAGTDTTVTTLRWGLLLMAKY-PEIQAKVQDEIERVIG----GRQ--------PVVEDRKNL 2Y1 39a VSTVLNL---YLAGTETTSSTIRYALNVLIRH-PKIQEKMQEDIDSVIG----QGR-------CPYVEDRKSL 2K10 19693LYSLSNL---FGAGTDTTATTLRWGLLLMAKY-PRIQGQVQQELSMVVG-----NR-------RVCVEDRKNL 2K11 MSTVMNL---FNAGTDTTATTLRWGLLLMAKY-PLIQDQVQEELRRVIG-----SR-------QVQVEDRKSL 2R1 IFSVGEL---IIAGTETTTNVLRWAILFMALY-PNIQGQVQKEIDLIMG----PNG-------KPSWDDKCKM 2S1 LMTVIYL---LFAGTMTVSTTVGYTLLLLMKY-PHVQKWVREELNRELG----AGQ-------APSLGDRTRL 2T2P VMT-THF---FFGVTETTSTTLCYGLLILLKY-LEVAAKVQ-ELDPVVG----WRP-------APSLDYRVCL 2D6 RIVVADL---FSAGMVTTSTTLAWGLLLMILH-PDVQRRVQQEIDDVIG----QVR-------RPEMGDQAHM 1A1 INIVLDL---FGAGFDTVTTAISWSLMYLVMN-PRVQRKIQEELDTVIG----RSR-------RPRLSDRSHL 1A2 VNLVNDI---FGAGFDTVTTAISWSLMYLVTK-PEIQRKIQKELDTVIG----RER-------RPRLSDRPQL 1B1 PATITDI---FGASQDTLSTALQWLLLLFTRY-PDVQTRVQAELDQVVG----RDR-------LPCMGDQPNL 1B2 3008aEVTMADL---IGAGLDTVSTALHWMLLLLVKH-PELQSKLHQLIDRVVG----RNR-------LPSIEDRSSL 1B3 3008bEATITDL---IGAGQDTVSTVLQWIVLLLVKH-PDKQAKLHELMDKVVG----QDR-------LPTTEDRSSL 1B1 1553 IPTVGDV---FGASQDTLSTALQWIFLVLVRY-PDMQQRLQEEVDLVVG----RQR-------LPCIEDQQQL 17 LTTIGDI---FGAGVETTTSVVKWTLAFLLHN-PQVKKKLYEEIDQNVG----FSR-------TPTISDRNRL 17A1 4175 LMTVGDI---FGAGVETTTTVMKWAITYLIHH-PQIQSRIQEELDSRVG----MDR-------SPQLSDRGSL 17A2 8086 LMTAAEA---FGAGVETTSTTLLWILAYLLHH-PQVQERVQKELDDHVG----SER-------PVRVSDRARL 21 HMAAVDL---LIGGTETTANTLSWAVVFLLHH-PEIQQRLQEELDHELGPGASSSR-------VP-YKDRARL 21 15 HMATVDL---LIGGSETTAAWLNWTVAFLLHR-PEFQTKVYEELCTVL-----EGR-------YPKYSDRQRL 3A4 VAQSIIF---IFAGYETTSSVLSFIMYELATH-PDVQQKLQEEIDAVLP----NKA-------PPTYDTVLQM 3A5 AAQSIIF---IFAGYETTSSVLSFTLYELATH-PDVQQKLQKEIDAVLP----NKA-------PPTYDAVVQM 3A7 MAQSIIF---IFAGYETTSSVLSFIIYELATH-PDVQQKVQKEIDTVLP----NKA-------PPTYDTVLQL 3A43 VAQSIII---IFAAYDTTSTTLPFIMYELATH-PDVQQKLQEEIDAVLP----NKA-------PVTYDALVQM 3A47 600 VSQLTVL---LTGGYETSTLALTLSIYSLATN-PGSMNRLQEEIDATFP----DAA-------PVTYEALMQM 3B1 2213aLSQAFIF---IFGGYETTTTTLTNVLYGLAIN-PDVLQVLHKEIDTNIP----SDA-------PISYEDLMGL 3B2 2213bLSQSVLF---IFGGYDTTTITITYLLYNLAIN-PDVLQILHSEIDSNFP----KDT-------PFSYEDLVGF 3A48 LAQAMIF---IFGGYETTSSSLGFLAYNLATN-PKIQKKLQEEIDKTFP----GKV-------RPNYDDLMQL 3A49 LAQAMIF---IFAGYETTSSSLGFLAYNLATN-PKIQKKLQEEIDKTFP----GKV-------RPNYDDLMQL 3A50P MVQALIF---ALVGNGNMAYLVAFTAYNLAVH-PQTQTRLQAEIDRTFP----GKV------SPNSYEELLQL 3A27 troutLSQAMIF---IFAGYETSSSTMSFLAYNLATN-HHVMTKLQEEIDTVFP----NKA-------PIQYEALMQM 5A1 VGQAFIF---LIAGYEIITNTLSFATYLLATN-PDCQEKLLREVDVFKEK---HMA-------PEFCSLEEGL 5A1 1244 VGQAFVF---LVAGYETSSNTLAFACYLLAIN-PECQRELQKEVDHFFT----RHE-------SPDYTNVQEL 4A11 RAEVDTF---MFEGHDTTASGISWILYALATH-PKHQERCREEIHSLLG----DGA-------SITWNHLDQM 4A22 RAEVDTF---MFEGHDTTASGISWILYALATH-PKHQERCREEIHGLLG----DGA-------SITWNHLDQM 4A20 QAEVKTF---MFAGHDTTSSAISWILYCLAKY-PEHQQRCRDEIRELLG----DGS-------SITWEHLSQM 4B1 RAEVDTF---MFEGHDTTTSGISWFLYCMALY-PEHQHRCREEVREILG----DQD-------FFQWDDLGKM 4F2 RAEADTF---MFEGHDTTASVSPGSCTTLQST-QNTRSVCRQEVQELLK----DRE-----PKEIEWDDLAHL 4F3 RAEADTF---MFEGHDTTASGLSWVLYHLAKH-PEYQERCRQEVQELLK----DRE-----PKEIEWDDLAQL 4F8 RAEADTF---MFGGHDTTASGLSWVLYNLARH-PEYQERCRQEVQELLK----DRE-----PKEIEWDDLAQL 4F11 RAEADTF---MFEGHDTTASGLSWVLYHLAKH-PEYQEQCRQEVQELLK----DRE-----PIEIEWDDLAQL 4F12 RAEADTF---MFGGHDTTASGLSWVLYNLARH-PEYQERCRQEVQELLK----DRD-----PKEIEWDDLAQL 4F22 RAEADTF---MFEGHDTTSSGISWMLFNLAKY-PEYQEKCREEIQEVMK----GRE-----LEELEWDDLTQL 4F28 2425 QAEANTF---MFAGHDTTASAICWSLYNLAHH-NHYQEQCRQEVMDLME----GRD-----VDEIKWEDLSSL 4X1 HSEVSTF---LLAGHDTLAASISWILYCLALN-PEHQERCREEVRGILG----DGS-------SITWDQLGEM 4V2 REEVDTF---MFEGHDTTAAAINWSLYLLGSN-PEVQKKVDHELDDVKS----DRP--------ATVEDLKKL 4V5 485 QEEVDTF---MFRGHDTTAASMNWVLHLMGSH-PEAQSKVHQELQEVFG----ESN------RPITTEDLKKL 4T5 8637 RAEVDTF---MFEGHDTTASGISFLLYNLACH-PKHQKLCRKEIMQVLH----GKD-------TMDWEDLNKI 4T2seabassRAEVDTF---MFEGHDTTASGISFILYSLACH-PEHQKICRDEIMQVLD----GKD-------TMDWEDLSKI 46 LDNFVTF---FIAGHETSANHLAFTVMELSRQ-PEIVARLQAEVDEVIG----SKR-------YLDFEDLGRL 46 4537 LDNFLTF---FIAGQETTANQLGFCIMELGRH-PDILERVKKEVDEAIG----MKQ-------DISYDDLGHL 20 LEDSMIF---SLASCIITAKLCTWAICFLTTS-EEVQKKLYEEINQVFG----NGP--------VTPEKIEQL 20 486 MEDCMVF---MLAGCAITANVCIWALHFLSTS-EEVQDRLYKEFEEVLG----SSP--------VSLEKIPQL 26A1 KQSSTEL---LFGGHETTASAATSLITYLGLY-PHVLQKVREELKSKGLLCKSNQDN------KLDMEILEQL 26A1 12575KESATEL---LFGGHETTASTATSLIMFLGLN-PEVLDKLRHELSDKVMHKGFLDLR------SLNLETLEQL 26B1 4267 KESTIEL---IFAAFATTASASTSLIMQLLRH-PPVLERLREELRARGLLHNGCLCPEG----ELRLDTIVSL 26C1 11741KETAVEL---IFAAHSTTASAATSLVLQLLHH-PEVVERVRVELEAQKLCTFPQSQCHAS---NLSLDKLNQL 26B1 KDGTLEL---IFAAYATTASASTSLIMQLLKH-PTVLEKLRDELRAHGILHSGGCPCEG----TLRLDTLSGL 26C1 KESAVEL---LFAAFFTTASASTSLVLLLLQH-PAAIAKIREELVAQGLGRACGCAPGCGCEPDLSLAALGRL 11A1 KANVTEM---LAGGVDTTSMTLQWHLYEMARN-LKVQDMLRAEVLAARH-----QAQG-----DMATM-LQLV 11A1 1630 KASITEL---MAGGVDTTSITLLWTLYELARH-PNLQEELRAEVAAART-----ESQ------GDMLEMLKRI 11B1 KANSMEL---TAGSVDTTVFPLLMTLFELARN-PNVQQALRQESLAAAA-----SISE-----HPQKA-TTEL 11B2 KANSMEL---TAGSVDTTAFPLLMTLFELARN-PDVQQILRQESLAAAA-----SISE-----HPQKA-TTEL 11B1 fugu KANITEL---MAGAVDTTAVPLQFALFELGRN-PEVQQRVRQQVQESWA-----QAGG-----DPQKA-LQEA 27A1 MGSLPEL---LMAGVDTTSNTLTWALYHLSKN-PEIQEALHEEVVGVVP-----AGQV------PQHKDFAHM 27A1 3437 YGSVSEL---LLAGVDTTSNTLTWTLHLLSKY-PQCQEILFKEVSTSVP-----ADRA------PSAEEVTRM 27A2 697 STCITDL---LLGGVDTTSNTLSWALYHLAKD-PVAQDRLYDEVNSVCP-----NHHQ------PTTDDLANM 27A3 LGSITEL---LLAGVDTTSNTISWALYQLAQN-PSIQDQLYHEVRSVCP-----GNKM------PDSDDIAQM 27B1 LGNVTEL---LLAGVDTVSNTLSWALYELSRH-PEVQTALHSEITAALS-----PGSS----AYPSATVLSQL 27B1 470 YSNVTEL---LLAGVDTISSTLSWSLYELSRH-QAVQASLREEVLSVLG-----GRRV------PTAADVAQM 27C1 YANVTEM---LLAGVDTTSFTLSWTVYLLARH-PEVQQTVYREIVKNLG-----ERHV------PTAADVPKV 27C1 1410 YANVTEM---LLAGVDTTSFTLSWASYLLARH-PDVQQQIHAEVMRVLG-----SEKV------ATAEDVQHL 24 YAAVTEL---QLAAVETTANSLMWILYNLSRN-PQVQQKLLKEIQSVLP-----ENQR-----PREED-LRNM 24 1804 YAAITEL---QIGGVETTANSMLWAIFNLSRN-PGAQRRLLEEIRTVVP-----PEQ------DPCGEHIKSM 19 NQCILEM---LIAAPDTMSVSLFFMLFLIAKH-PNVEEAIIKEIQTVIG-----ER-------DIKIDDIQKL 19ov 7098 MQCVLEM---VIAAPDTLSVSLFFMLLLLKQN-PDVELQLLQEIDAVVG-----KR-------QLQNGDLQKL 19br 4200 RQCVLEM---VIAAPDTLSISLFFMLMLLKQH-PDVELRIVEELSTV-------SR-------TEGEENIDYQ 8A1 ARALVLQ---LWATQGNMGPAAFWLLLFLLKN-PEALAAVRGELESILWQAEQPVSQTT----TLPQKVLDST 8A2 5061 RRASLLQ---LWTTQCNNGPAAFWLLGFLLTH-PEAMEALKSEIRQFNLQDPAVRHRTS------GSPDSRRT 8A1 4451 TRALLLQ---LWATQGNVGPAAFWMLGYLLTH-PEALTAVKTEMEALQLSPLDSSVV---------------T 8B1 DKFNFMM---LWASQGNTGPTSFWALLYLLKH-PEAIRAVREEATQVLGEARLETKQSFA---FKLGA-LQHT 8B1 7782 TRYMFVL---LWASQGNTGPSSFWLLLFLMKH-PEAMRSVKEEIDKVVRESGQEVKPGGPLV-NLSREMLMKT 8B2 21917TRYMFVL---LWASQGNTGPSSFWLLLFLMKH-PEAMRSVKEEIDKAVRESGQEVKPGGPLV-KMSREMLMKT 7B1 GAHHLGF---LWASVANTIPTMFWAMYYLLRH-PEAMAAVRDEIDRLLQSTGQKKGSGFPI--HLTREQLDSL 7A1 AKTHLVV---LWASQANTIPATFWSLFQMIRN-PEAMKAATEEVKRTLENAGQKVSLEGNPI-CLSQAELNDL 7A1 5172 ARTHVAL---LWASQANTLPATFWSLFYMIRS-PDAIKAAREEAQKVFETFGVKIDPHNPTL-NLTRDVLDNM 7C1 16085AAHHFAM---LWASVANTIPACFWSMYNLVSH-PDALQVVRQQILDELKLSGVQFSTDTDV--TLSRDLLDKL 39A1 PNYGLLL---LWASLSNAVPVAFWTLAYVLSH-PDIHKAIMEGISSVFGKAGKDKI-------KVSEDDLENL 51 AGMLIGL---LLAGQHTSSTTSAWMGFFLARD-KTLQKKCYLEQKTVCGE---NLP-------PLTYDQLKDL 51 437 GGMLIGL---LLAGQHTSSTTSAWMGFFMARD-RRLQERCYAEQKAACGE---DLP-------PLSFDQLKDL 2C9 PYTDAVVHEVQRYIDLLPTSL--PHAVTCDIKFRN--------YLIPKGTTILISLTSVLHDNKE-FPNP 2C19 PYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRN--------YLIPKGTTILTSLTSVLHDNKE-FPNP 2C18 PYTDAVVHEIQRYIDLLPTNL--PHAVTCDVKFKN--------YLIPKGTTIITSLTSVLHNDKE-FPNP 2C8 PYTDAVVHEIQRYSDLVPTGV--PHAVTTDTKFRN--------YLIPKGTTIMALLTSVLHDDKE-FPNP 2E1 PYMHAVVHEIQRFITLVPSNL--PHEATRDTIFRG--------YIIPKGTVIVPTLDSVLYDNQE-FPDP 2F1 PYTDAVIHEVQRFADIIPMNL--PHRVTRDTAFRG--------FLIPKGTDVITLLNTVHYDPSQ-FLTP 2W1 PYTSAVLHEVQRFITLLPHV---PRCTAADTQLGG--------FLLPKGTPVIPLLTSVLLDETQ-WQTP 2B6 PYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRG--------YIIPKDTEVFLILSTALHDPHY-FEKP 2A6 PYMEAVIHEIQRFGDVIPMSL--ARRVKKDTKFRD--------FFLPKGTEVYPMLGSVLRDPSF-FSNP 2A7 PYMEAVIHEIQRFGDVIPMSL--ARRVKKDTKFRD--------FFLPKGTEVFPMLGSVLRDPSF-FSNP 2A13 PYTEAVIHEIQRFGDMLPMGL--AHRVNKDTKFRD--------FFLPKGTEVFPMLGSELRDPRF-FSNP 2G1P PYTDVVIHEIQRLVDIVPMGV--PHNIIQDTQFRG--------YLLPKGTDVFPLLGSVLKDPKY-FRYP 2G2P PYTDAVIHEIQRLVDIVPMGV--PHNLIRDTQFRG--------YLLPKGTDVFPLLGSVLKDPKY-FRYP 2M1 troutPYTDAVIHEVQRYMDLSPTSV--PHKVMRDTEFYN--------YHIPEGTMVLPLLSSVLVDPKL-FKNP 2J2 PYTNAVIHEVQRMGNIIPQNV--PREVTVDTTLAG--------YHLPKGTMILTNLTALHRDPTE-WATP 2X2 4007PYMQAVIHEVQRVANTVPLSV--FHCTTKDTEFMG--------YSIPKGTLIIPHLASVLKEEGQ-WKFP 2X3 PYVQAVIHEIQRTANTVPLSV--FHCTTRDTELMG--------YSIPKGTLIIPNLSSVLNEKGQ-WKSS 2X1catfishPYTQAVVHECQRIARTVPLSV--FHCTTRDTELMG--------YTIPKGTMIIPNLSSVLSEEGQ-WKFP 2V1 DanioPYTDAVIHEIQRMGNVVPLSV--PRMTNEDTLLEG--------Y-IPKGTQIIPNLTSVLFDQTK-WKTQ 2Z2 2993bPYTDAVLHEIQRFGNIVPLSL--PHVTNKAIQLEG--------YNIPKGIMIIPNLTSALFDKNE-WETP 2P3 killiPYTDAVIHEIQRMGNIIPLNL--PRMANKDTTLDK--------YSIPKGTIIIPTLHSVLQDKSI-WETP 2P4 PYTNAVIHEMQRMANIIPLNV--VHMASSDTTIGN--------YTIPKGTIIMPTLNSVLHDESM-WETP 2N2 killiPYTDAVIHEIQRIGNILPLNG--MRVAAKDTTLGG--------YFIPKGTSLMPVLTSVLFDKAE-WACP 2N11 3261cPYTDAVIHEIQRMGNIVPLNA--SRMAAKDTTLGG--------YFIPKGTSLLPILTSVLFDKNE-WETP 2N10 3261bPYTDAVIHEIQRMGNIVPLNG--PRMAAKDTTLGG--------YFIPKGTSLMPILTSVLFDKNE-WETP 2N12 3261dPYTDAVIHEIQRFANVVPAGF--PKMATKDTTVGG--------YFIPKGLAITTMLSSVLFDKNE-WETP 2N9 3261aPYTDAVIHEIQRMGNIVPLNG-PSNGCQGTRPWRG--------YFIPKGTSVMPNLTSVLFDKNE-WETP 2Y2 39b PFTDAVIHEVQRFLDIVPFGL--PHYALKDITFRG--------YSIPKGTVIIPLLHSVLKG-DQ-WETP 2R1 7138 PYVEAVLHEVLRFCNIVPLGI--FRATSQDANVNG--------YTIPKGTMVITNLYSVHFDEKY-WSDP 2U1 8899 PFTEAAIMEVQRLTTVVPLAI--PHMTS-ETEFMG--------YTIPKGTVVLPNLWSVHRDPTE-WDDP 2U1 PYTEATIMEVQRLTVVVPLAI--PHMTS-ENTLQG--------YTIPKGTLILPNLWSVHRDPAI-WEKP 2Z1 2993aPYTNAVIHESLRMGNVVPLSL--LHATGRDIQLEG--------YTIPKGTTVIANLTSALFDKNE-WETP 2K9 12487PYMEAVIHETQRMANIVPMSL--PHRTS-DT-FQG--------YVIKKGTMVIPLLTSVLYDESQ-WEKP 2K6 DanioPYTDAVIHEIQRFADISPIGA--PRQTTCDVHLNG--------YFIKKGTPVFPLLVSVLRDE-E-WETP 2Y1 39a PFTDAVLHEIQRYLDMIPFSI--PHYALQDISFRG--------YTIPKDTLIIPLLHSVLKDDKM-WETP 2K10 19693PYVDAVIHEIQRLGNIAPMAV--PHKTARDVEFRG--------YFIEKGTTVFPLLTSVLYDENE-WETP 2K11 PFTDAVIHETQRLANIVPMAL--PHKTSQDVTLQG--------FFIEKGTTVYPLLTSVLYDETE-WEKP 2R1 PYTEAVLHEVLRFCNIVPLGI--FHATSEDAVVRG--------YSIPKGTTVITNLYSVHFDEKY-WRDP 2S1 PYTDAVLHEAQRLLALVPMGI--PRTLMRTTRFRG--------YTLPQGTEVFPLLGSILHEPNI-FKHP 2T2P PYANAVLLEIQCFISVVPLGL--PRTLTLDTHLHS--------HCLPKGTFVIPLLVTAHRDPTQ-FKDP 2D6 PYTTAVIHEVQRFGDIVPLGM--THMTSRDIEVQG--------FRIPKGTTLITNLSSVLKDEAV-WEKP 1A1 PYMEAFILETFRHSSFVPFTI--PHSTTRDTSLKG--------FYIPKGRCVFVNQWQINHDQKL-WVNP 1A2 PYLEAFILETFRHSSFLPFTI--PHSTTRDTTLNG--------FYIPKKCCVFVNQWQVNHDPEL-WEDP 1B1 PYVLAFLYEAMRFSSFVPVTI--PHATTANTSVLG--------YHIPKDTVVFVNQWSVNHDPVK-WPNP 1B2 3008aAYLDAFIYETMRFTSFVPVTI--PHSTTSDVTIEG--------LRIPKDTVVFINQWSVNQDPLM-WKDP 1B3 3008bAYLDAFIYETMRFTSFVPVTI--PHSTTSDVTIEG--------LRIPKDTVVFINQWSVNHDPLK-WKDP 1B1 1553 PWVMAFIYEVMRFTSFVPLTI--PHSTTTDTTIMG--------YTIPKNTIIFINQWSINHDPTI-WSHP 17 LLLEATIREVLRLRPVAPMLI--PHKANVDSSIGE--------FAVDKGTEVIINLWALHHNEKE-WHQP 17A1 4175 PYLEATIREVLRIRPVAPLFI--PHVALSDTSIGD--------FAVKKGTRVVINLWSLHHDEKE-WENP 17A2 8086 TYLDCVINEGMRIRPVSPVLI--PHTAMTDSRIGG--------HHISRGTRVLVNMWSIHHDSAH-WDKP 21 PLLNATIAEVLRLRPVVPLAL--PHRTTRPSSISG--------YDIPEGTVIIPNLQGAHLDETV-WERP 21 15 PILCSLIHEVLRLRPVAPLAV--PHKAIRDSSIAG--------YFIPRNTIIIPNLFGAHHDPEV-WSDP 3A4 EYLDMVVNETLRLFPIAMRLE--RVCK-KDVEING--------MFIPKGWVVMIPSYALHRDPKY-WTEP 3A5 EYLDMVVNETLRLFPVAIRLE--RTCK-KDVEING--------VFIPKGSMVVIPTYALHHDPKY-WTEP 3A7 EYLDMVVNETLRLFPVAMRLE--RVCK-KDVEING--------MFIPKGVVVMIPSYVLHHDPKY-WTEP 3A43 EYLDMVVNETLRLFPVVSRVT--RVCK-KDIEING--------VFIPKGLAVMVPIYALHHDPKY-WTEP 3A47 600 EYVDCVINECLRLYPPAARLE--RTAK-ETVEISG--------ITIPKNMTVTVPIFALHRDPEH-WPEP 3B1 2213aQYLDQVLNESQRLYPTAPRLE--RACK-KTVQIHG--------LTILEGTIVGIPVHLLHKDPRF-WSSP 3B2 2213bQYLDQVLNESQRLIPTAPALE--RFCK-KTVQIHG--------LTIPEGTVVAVPVHLLHKDPRF-WSSP 3A48 EYLDMVVNESMRVFPILSRLE--RMTK-TSVEING--------FTIPKGTVVAIPVYVLQHDKAY-WPEP 3A49 EYLDMVVNESMRLYPIANRLE--RMTK-TSVEING--------LTIPKGTVVAIPVYALQRDPVL-WPEP 3A50P KYLDMVVTETSRLYPLGNRIE--RVAK-STVEVSG--------VIIPEGVAVAVPIYTLHRDPTV-WPDP 3A27 troutDYLDCVLNESLRLYPIAPRLE--RVAK-KTVEING--------IVIPKDCIVLVPTWTLHRDPEI-WSDP 5A1 PYLDMVIAETLRMYPPAFRFT--REAA-QDCEVLG--------QRIPAGAVLEMAVGALHHDPEH-WPSP 5A1 1244 KYLDMVISETLRLYPPGFRFA--REIE-RDCVVNG--------QSFPKGATFEIPAGFLHRDPEH-WPDP 4A11 PYTTMCIKEALRLYPPVPGIG--RELSTPVTFPDG--------RSLPKGIMVLLSIYGLHHNPKV-WPNP 4A22 PYTTMCIKEALRLYPPVPGIG--RELSTPVTFPDG--------RSLPKGIMVLLSIYGLHHNPKV-WPNL 4A20 PYTTMCIKECLRLYAPVVNIS--RLLDKPITFPDG--------RSLPAGITVFINIWALHHNPYF-WEDP 4B1 TYLTMCIKESFRLYPPVPQVY--RQLSKPVTFVDG--------RSLPAGSLISMHIYALHRNSAV-WPDP 4F2 PFLTMCMKESLRCIPPVPVIS--RHVTQDIVLPDG--------RVIPKGIICLISVFGTHHNPAV-WPDP 4F3 PFLTMCIKESLRLHPPVPAVS--RCCTQDIVLPDG--------RVIPKGIICLISVFGTHHNPAV-WPDP 4F8 PFLTMCLKESLRLHPPIPTFA--RGCTQDVVLPDS--------RVIPKGNVCNINIFAIHHNPSV-WPDP 4F11 PFLTMCIKESLRLHPPVPVIS--RCCTQDFVLPDG--------RVIPKGIVCLINIIGIHYNPTV-WPDP 4F12 PFLTMCVKESLRLHPPAPFIS--RCCTQDIVLPDG--------RVIPKGITCLIDIIGVHHNPTV-WPDP 4F22 PFTTMCIKESLRQYPPVTLVS--RQCTEDIKLPDG--------RIIPKGIICLVSIYGTHHNPTV-WPDS 4F28 2425 PFTTMCIRESLRLHSPVQAVT--RRYIQDVKLPGE--------RTVPKGAICLVSIYGTHHNPAV-WTNP 4X1 SYTTMCIKETCRLIPAVPSIS--RDLSKPLTFPDG--------CTLPAGITVVLSIWGLHHNPAV-WKNP 4V2 RYLECVIKETLRLFPSVPLFA--RSVSEDYFLTAG--------YRVLKGTEAVIIPYALHRDPRY-FPNP 4V5 485 KYLESVIKEALRLFPSVPFFA--RSLGEDC-HING--------FKVPKGANAVIITYALHRDPRY-FPEP 4T5 8637 PYTTMCIKESLRMHPPVPGIS--RKTTKPITFFDG--------RTLPAESRIGTSVFGIHRNASL-WENP 4T2seabassPYTTMCIKESLRIYPPVPGMS--RKITKPITFCDG--------RTLPEGSYIGTSVFGIHRNGIV-WENP 46 QYLSQVLKESLRLYPPAWGTF--RLLEEET-LIDG--------VRVPGNTPLLFSTYVMGRMDTY-FEDP 46 4537 GYLSQVLKETLRLYPTAPGTS--RDLKEDM-VIGG--------VHVPGGVVCVFSSYGMGRMETF-FKDP 20 RYCQHVLCETVRTAKLTPVSA--QLQD-IEGKIDR--------FIIPRETLVLYALGVVLQDPNT-WPSP 20 486 RYCQQVLNETLRTAKLTPIAA--RLQE-VEGKVDQ--------HLIPKESLVIYALGVILQDSDT-WNAP 26A1 KYIGCVIKETLRLNPPVPGGF--RVAL-KTFELNG--------YQIPKGWNVIYSICDTHDVAEI-FTNK 26A1 12575KYTSCVIKETLRMNPPVPGGF--RVAL-KTFELGG--------YQIPKGWNVIYSICDTHDVAEI-FPNK 26B1 4267 KYLDCVIKEVLRLFTPVSGAY--RTAM-QTFELDG--------VQIPKGWSVMYSIRDTHDTSTV-FKDV 26C1 11741HYIDCVIKEVLRFLPPVSGGY--RTAL-QTFELDG--------YQIPKGWTVMYSIRDTHETAEI-FQNP 26B1 RYLDCVIKEVMRLFTPISGGY--RTVL-QTFELDG--------FQIPKGWSVMYSIRDTHDTAPV-FKDV 26C1 RYVDCVVKEVLRLLPPVSGGY--RTAL-RTFELDG--------YQIPKGWSVMYSIRDTHETAAV-YRSP 11A1 PLLKASIKETLRLHPISVTLQ--RYLV-NDLVLRD--------YMIPAKTLVQVAIYALGREPTF-FFDP 11A1 1630 PLVKGALKETLRLHPVAVSLQ--RYIA-EDIIIQN--------YHIPAGTLVQLGLYAMGRDPKV-FFRP 11B1 PLLRAALKETLRLYPVGLFLE--RVAS-SDLVLQN--------YHIPAGTLVRVFLYSLGRNPAL-FPRP 11B2 PLLRAALKETLRLYPVGLFLE--RVVS-SDLVLQN--------YHIPAGTLVQVFLYSLGRNAAL-FPRP 11B1 fugu PLLKGTIRETLRLYPVGTTVQ--RYPV-KDIVLQN--------YHIPAGTMVQACLYPLGRSAEV-FEDP 27A1 PLLKAVLKETLRLYPVVPTNS--RIIE-KEIEVDG--------FLFPKNTQFVFCHYVVSRDPTA-FSEP 27A1 3437 PYLRAVVKESLRMFPVIPMNG--RILADKDVMIGG--------YQFSKNTAFNFSHYAIGRDEDT-FPEP 27A2 697 PFLKAVIKEVLRLYPVVHQNA--RFISENDVILND--------YWFPKKTQFHLCHYSVCHDETQ-FKHA 27A3 PYLKAVIRETLRLYPVVPGNA--RVTVDKEIVVGG--------YLFPKQTLFHLCHYCVSHDENI-FPNS 27B1 PLLKAVVKEVLRLYPVVPGNS--RVPD-KDIHVGD--------YIIPKNTLVTLCHYATSRDPAQ-FPEP 27B1 470 PLLKATIKEVLRLYPVIPANA--RVITERDIQVGG--------YLIPKNTLITLCHYATSRDPAV-FPRP 27C1 PLVRALLKETLRLFPVLPGNG--RVTQ-EDLVIGG--------YLIPKGTQLALCHYATSYQDEN-FPRA 27C1 1410 PFIRGLVKETLRLFPVLPGNG--RITQ-DDMVLGG--------YFIPKGTQLALCHYSTSLDDEN-FPSS 24 PYLKACLKESMRLTPGVPFTT--RTLD-KATVLGE--------YALPKGTVLMLNTQVLGSSEDN-FEDS 24 1804 PYLKACLKESMRISPSVPFTS--RTLD-KDTVLGD--------YAIPKGTVLMINSHALGSSEDY-FDDG 19 KVMENFIYESMRYQPVVDLVM--RKAL-EDDVIDG--------YPVKKGTNIILNIGRMHR-LEF-FPKP 19ov 7098 RVLETFINECLRFHPVVDFTM--RRSL-SDDVIEG--------YRVPKGTNIILNTGHMHR-TEF-FLRP 19br 4200 KVMESFINESMRFHPVVDFTM--RKAL-EDDTIEG--------IRIRKGTNIILNIGLMHK-TEF-FPKP 8A1 PVLDSVLSESLRLTAAPFIT---REVV-VDLAMPMADGREF--NLRRGDRLLLFPFLSPQRDPEI-YTDP 8A2 5061 PVFDSILSETLRLTAAVLIS---RVVV-GDKVLRMASGQQY--KLRRGDKAILFPFLSPQMDPEI-HLEP 8A1 4451 PVFDSALDEALRLTAAPFIT---REVL-QDKVLHMADGQQY--LLRKGDRVCLFPFISPQMDPEI-HQEP 8B1 PVLDSVVEETLRLRAAPTLL---RLVH-EDYTLKMSSGQEY--LFRHGDILALFPYLSVHMDPDI-HPEP 8B1 7782 PILDSAVEETLRLTAAPLLT---RAVL-QDMTLKMADGQQY--FIRQGDRVALFPYSAIQMDPEI-HPDP 8B2 21917PILDSAVEETLRLTAAPLLT---RAVL-QDMTLKMADGRQY--FIRQGDRVALFPYSAVQMDPEI-HPDP 7B1 ICLESSIFEALRLSSYSTTI---RFVE-EDLTLSSETGDY---CVRKGDLVAIFPP-VLHGDPEI-FEAP 7A1 PVLNSIIKESLRLSSASLNI---RTAK-EDFTLHLEDGS----YNIRKDSIIALYPQLMHLDPEI-YPDP 7A1 5172 PVLDSIIKEAMRLSSASLNI---RVAK-EDFLLHLDNQEA---YRIRKDDVIALYPPMLHYDPEI-FEDP 7C1 16085LYLESSVNESLRLSSASMNI---RVAQ-EDFSLHLKNERS---ANVRKGDIIVLYPQSLHMDPEV-YEDP 39A1 LLIKWCVLETIRLKAPGVIT---RKVV-KPVEILN--------YIIPSGDLLMLSPFWLHRNPKY-FPEP 51 NLLDRCIKETLRLRPPIMIMM--RMAR-TPQTVAG--------YTIPPGHQVCVSPTVNQRLKDS-WVER 51 437 SLLEGCLKETLRLRPPIMTMM--RMAR-SPQTAAG--------YTIPVGHQVCVSPTVNHRLGDA-WEQR 2C9 -EMFDPHHFLDEGG--------------------NFKKSKYFMPFSAGKRICVGEALAGMELFLF-LTSI 2C19 -EMFDPRHFLDEGD--------------------NFKKSNYFMPFSAGKRICVGEGLARMELFLF-LTFI 2C18 -EMFDPGHFLDKSG--------------------NFKKSDYFMPFSAGKRMCMGEGLARMELFLF-LTTI 2C8 -NIFDPGHFLDKNG--------------------NFKKSDYFMPFSAGKRICAGEGLARMELFLF-LTTI 2E1 -EKFKPEHFLNENG--------------------KFKYSDYFKPFSTGKRVCAGEGLARMELFLL-LCAI 2F1 -QEFNPEHFLDANQ--------------------SFKKSPAFMPFSAGRRLCLGELLARMELFLY-LTAI 2W1 -GQFNPGHFLDANG--------------------HFVKREAFLPFSAGRRVCVGERLARTELFLL-FAGL 2B6 -DAFNPDHFLDANG--------------------ALKKTEAFIPFSLGKRICLGEGIARAELFLF-FTTI 2A6 -QDFNPQHFLNEKG--------------------QFKKSDAFVPFSIGKRNCFGEGLARMELFLF-FTTV 2A7 -QDFNPQHFLDDKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-FTTV 2A13 -QDCSPQHFLDEKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-FTTI 2G1P -DAFYPQHFLDEQG--------------------RFKKNEAFVPFSSGKRICLGEAMARMELFLY-FTST 2G2P -DAFYPQHFLDEQG--------------------RFKKNEAFVPFSSGKRICLGEAMDRMELFLY-FTST 2M1 trout-DEFDPENFLDENG--------------------VFKKNDGFFAFGVGKRACPGEALARVELFLF-FTSV 2J2 -DTFNPDHFL-ENG--------------------QFKKREAFMPFSIGKRACLGEQLARTELFIF-FTSL 2X2 4007-NEFNPDNFLNDDG--------------------EFVKPEAFMP-STGPRVCLGEGLARMELFLI-IVTL 2X3 -HEFNPENFLNENG--------------------EFVQPEAFMPFSTGPRVCLGEGLARMELFII-LVSL 2X1catfish-HDFNPSNFLNEQG--------------------QFEKPEAFIPFSAGPRVCLGEGLARMELFLF-LVTL 2V1 Danio-HSFDPQNFLNAQG--------------------K-EKPEAFIPFSLGKRSCPGESLARMELFLF-FTSF 2Z2 2993b-CTFNPGHFLDNEG--------------------KFRKRAAFIPFSAGKRLCLGENLARMELFLF-FTSF 2P3 killi-QTFNPQHFLDQDG--------------------QFRKRDAFMPFSTGKRVCLGEQLARMELFLF-FTSL 2P4 -HSFNPQHFLDQDG--------------------KFRKREAFLPFSAGKRVCLGEQLARMELFLF-FTSL 2N2 killi-DTFNPGHFLDDNG--------------------KFVKRDAFLPFSAGKRACIGESLAKMELFLF-LVAL 2N11 3261c-DKFNPGHFLDAEG--------------------KFKKREAFLPFSAGKRVCLGEGLVKMELFLF-FVSL 2N10 3261b-DKFNPGHFLDAEG--------------------KFKKREALLPFSAGKRVCLGEGLAKMELFLF-FVSL 2N12 3261d-DVFNPNHFLDSEG--------------------RFRKRDAFIPFSAGKRVCIGENLAKMELFLF-FTSI 2N9 3261a-DTFNPEHFLDAEG--------------------KFVRREAFLPFSAGRRACLGEGLARMELLLF-FVSL 2Y2 39b -WAFNPKHFLDQNG--------------------SFKKNSAFLPFSAGKRSCVGESLARMELFIF-LVTL 2R1 7138 -GVFSPQRFLDANG--------------------NFVRREAFLPFSLGRRQCLGEQLARMEMFLF-FTTL 2U1 8899 -DSFDPTRFLDEDG--------------------TLLRKECFIPFGIGRRVCMGAQLAKMELFLT-VTNL 2U1 -EDFYPNRFLDDQG--------------------QLIKKETFIPFGIGKRVCMGEQLAKMELFLM-FVSL 2Z1 2993a-FAFNPGHFLDEEG--------------------RFRKRTAFLPFSAGRRLCLGENLARMMLFLF-FTSF 2K9 12487-HTFNPAHFLDDEG--------------------RFVRRDAFMPFSAGRRMCLGEGLARMELFLF-FASL 2K6 Danio-DSFNPKHFLNKQG--------------------QFVKKDAFMPFGAGRRVCIGESLARMELFLF-FTSL 2Y1 39a -GSFNPQHFLDGNG--------------------SFKKNPAFLPFSAGKRACVGESLARMEIFLF-VVSL 2K10 19693-HTFNPSHFLDKDG--------------------KFIKRDAFMPFSAGRRLCLGEGLAKMEIFLF-FTSL 2K11 -LNFYPAHFLDKDG--------------------KFVKREAFLPFSAGRRICLGEGLAKMELFIF-FSTL 2R1 -EVFHPERFLDSSG--------------------YFAKKEALVPFSLGRRHCLGEHLARMEMFLF-FTAL 2S1 -EEFNPDRFLDADG--------------------RFRKHEAFLPFSLGKRVCLGEGLAKAEVFLF-FTTI 2T2P -DCFNPTNFLD-KG--------------------KFQGNDAFMPFAPAKQMCLGTGLAHSGIFLF-LTAT 2D6 -FRFHPEHFLDAQG--------------------HFVKPEAFLPFSAGRRACLGEPLARMELFLF-FTSL 1A1 -SEFLPERFLTPDG------------------AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF-LAIL 1A2 -SEFRPERFLTADG-----------------TAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF-LAIL 1B1 -ENFDPARFLDKDG------------------LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF-ISIL 1B2 3008a-HVFDPSRFMDEEG------------------SLDRDLACNVMIFSAGKRRCIGDQIAKVEVFLF-FAVL 1B3 3008b-HVFDPSRFLNENG------------------DLNKDLTSGVMIFSSGKRRCIGSQIAKVEVFLF-AAIL 1B1 1553 -ETFDPNRFLNPSG------------------SLNKDLTSRMLIFSMGKRRCIGEELSKLHLFLF-TALI 17 -DQFMPERFLNPAG------------------TQLISPSVSYLPFGAGPRSCIGEILARQELFLI-MAWL 17A1 4175 -ERFDPGRFLNSEG------------------TGLVIPSSSYLPFGAGVRVCLGEALAKMELFLF-LSWI 17A2 8086 -DLFNPDRFRDHQG-------------------QRVTP-SCFLPFGAGPRVCVGESLARLELFLF-LSSL 21 -HEFWPDRFLEPGK------------------------NSRALAFGCGARVCLGEPLARLELFVV-LTRL 21 15 -YSFKPERFLEGGG----------------------GSTRALIPFGGGARLCLGETVAKMELFLF-TAYL 3A4 -EKFLPERFSKKNK--------------------DNIDPYTYTPFGSGPRNCIGMRFALMNMKLA-LIRV 3A5 -EEFRPERFSKKK---------------------DSIDPYIYTPFGTGPRNCIGMRFALMNMKLA-LIRV 3A7 -EKFLPERFSKKNK--------------------DNIDPYIYTPFGSGPRNCIGMRFALVNMKLA-LVRV 3A43 -EKFCPERFSKKNK--------------------DSIDLYRYIPFGAGPRNCIGMRFALTNIKLA-VIRA 3A47 600 -EEFKPDRFSKQNK--------------------GRINPYTYLPFGIGPRKCLGMRLALVIVKLA-LVET 3B1 2213a-EEFRPERFSKDST--------------------EEVNPYAFMPFGLGPRNCVGMRYAILVMKML-IVRL 3B2 2213b-EEFRPERFSKDNI--------------------EEVNPYAFMPFGLGPRNCIGMRYAILVMKMI-LVRV 3A48 -EAFKPERFSKENK--------------------DNVDPYAYLPFGAGPRNCIGNRFALVLMKLA-IAEI 3A49 -EAFKPERFSKENK--------------------DNVDPYAYLPFGAGPRNCIGNRFALVLMKLA-IAEI 3A50P -DSFKPERFSKDNR--------------------DNIDPYGLL----GPRSCTGTRMSMLVVKLT-LVEI 3A27 trout-EEFKPERFSKENK--------------------ESIDPYTYMPFGAGPRNCIGMRFALIMIKLA-MVEI 5A1 -ETFNPERFTAEAR--------------------QQHRPFTYLPFGAGPRSCLGVRLGLLEVKLT-LLHV 5A1 1244 -DKFIPERFTPEAK--------------------ASRHPFVYIPFGAGPRNCVGMRLAQLEMKMA-LVRL 4A11 -EVFDPFRFAPG----------------------SAQHSHAFLPFSGGSRNCIGKQFAMNELKVA-TALT 4A22 -EVFDPSRFAPG----------------------SAQHSHAFLPFSGGSRNCIGKQFAMNQLKVA-RALT 4A20 -QVFNPLRFSRENS--------------------EKIHPYAFIPFSAGPRNCIGQHFAIIECKVA-VALT 4B1 -EVFDSLRFSTENA--------------------SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV-TAMC 4F2 -EVYDPFRFDPENI--------------------KERSPLAFIPFSAGPRNCIGQTFAMAEMKVV-LALT 4F3 -EVYDPFRFDPKNI--------------------KERSPLAFIPFSAGPRNCIGQAFAMAEMKVV-LGLT 4F8 -EVYDPFRFDPENA--------------------QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVV-LALT 4F11 -EVYDPFRFNQENI--------------------KERSPLAFIPFSAGPRNCIGQAFAMAEMKVV-LALT 4F12 -EVYDPFRFDPENS--------------------KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVV-LALM 4F22 -KVYNPYRFDPDNP--------------------QQRSPLAYVPFSAGPRNCIGQSFAMAELRVV-VALT 4F28 2425 -HDFDPLRFDPKNQ--------------------EGLSSHAFIPFSSGPRNCIGQKFALAELRVV-VALT 4X1 -KVFDPLRFSQENS--------------------DQRHPYAYLPFSAGSRNCIGQEFAMIELKVT-IALI 4V2 -EEFQPERFFPENA--------------------QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI-LSCI 4V5 485 -EEFRPERFLPENS--------------------VGRPPYAYLPFSAGLRNCIGQRFALIEEKVV-LASI 4T5 8637 -NVFDHWRFLPENV--------------------SKRSPHAFVPFSAGPRNCIGQNFAMNEMKVV-IAMT 4T2seabass-DVFDHWRFLPENV--------------------SKRSPHAFVPFSAGPRNCIGQNFAMNEMKVV-IALT 46 -LTFNPDRFGPG----------------------APKPRFTYFPFSLGHRSCIGQQFAQMEVKVV-MAKL 46 4537 -LKFDPDRFDPD----------------------APKPYYCYFPFSLGPRSCLGQNFAQMEAKVV-MAKL 20 -HKFDPDRFDDE----------------------LVMKTFSSLGFS-GTQECPELRFAYMVTTVL-LSVL 20 486 -YRFDPDRFEEE----------------------SVKKSFHLLGFS-GSQTCPELRFAYTVATVL-LSVL 26A1 -EEFNPDRFIAPHPED--------------------ASRFSFIPFGGGLRSCVGKEFAKILLKIF-TVEL 26A1 12575-EDFQPERFMMKNCGD--------------------SSRFQYIPFGGGSRMCVGKEFAKVLLKIF-LVEV 26B1 4267 -DVFDPDRFSQERGED-------------------KEGRFHYLPFGGGVRSCLGKQLATLFLRIL-AIEL 26C1 11741-ELFDPDRFVTAQVES-------------------RSSRFSYVPFGGGVRSCVGKELAQIILKTL-TIEL 26B1 -NVFDPDRFSQARSED-------------------KDGRFHYLPFGGGVRTCLGKHLAKLFLKVL-AVEL 26C1 -PEGFDPERFGAAREDSRG----------------ASSRFHYIPFGGGARSCLGQELAQAVLQLL-AVEL 11A1 -ENFDPTRWLSKDK---------------------NITYFRNLGFGWGVRQCLGRRIAELEMTIF-LINM 11A1 1630 -EQYQPSRWLRS-----------------------ETHYFKSLGFGFGPRQCLGRRIAEAEMQLF-LIHM 11B1 -ERYNPQRWLDIKG---------------------SGRNFYHVPFGFGMRQCLGRRLAEVEMLLL-LHHV 11B2 -ERYNPQRWLDIRG---------------------SGRNFHHVPFGFGMRQCLGRRLAEAEMLLL-LHHV 11B1 fugu -LRFDPGRWGKSREEGQRG----------------GGTGFRSLAFGFGARQCVGRRIAENEMQLL-LMHI 27A1 -ESFQPHRWLRNSQPATPR----------------IQHPFGSVPFGYGVRACLGRRIAELEMQLL-LARL 27A1 3437 -ATFMPERWLQDSHN--------------------RPNAFGAIAFGFGVRGCVGRRIAELEMYSF-LCHL 27A2 697 -ERFLPERWLRHSAPLSGYY---------------QHHPYSFIPFGVGVRACVGKRVAELEMYFA-LTR- 27A3 -RVFQPERWLRGREEKS------------------KQHPFGSVPFGFGVRACLGRRVAELEMYLL-LSR- 27B1 -NSFRPARWLGEGP---------------------TPHPFASLPFGFGKRSCMGRRLAELELQMA-LAQI 27B1 470 -DEFLPQRWLNKEQ---------------------SHHPYASVPFGVGKRSCIGRRIAELELYLA-VARI 27C1 -KEFRPERWLRKGDLD-------------------RVDNFGSIPFGHGVRSCIGRRIAELEIHLV-VIQL 27C1 1410 -LEFRPDRWIRKHSSD-------------------RLDNFGSIPFGYGIRSCIGKRIAELEMHLA-LIRI 24 -SQFRPERWLQEKE---------------------KINPFAHLPFGVGKRMCIGRRLAELQLHLA-LCWI 24 1804 -KKFKPERWLREHG---------------------TINPFAHVPFGIGKRMCIGRRLAELQMSLF-L-QL 19 -NEFTLENFAK------------------------NVPYRYFQPFGFGPRGCAGKYIAMVMMKAI-LVTL 19ov 7098 -TEFCLQNFEK------------------------NAPRRYFQPFGSGPRACVGKHIAMVMMKSI-LVTL 19br 4200 -REFSLTNFEQK-----------------------TVPSRFFQPFGCGPRSCVGKHIAMVMMKAI-LATL 8A1 -EVFKYNRFLNPDGSEKKDFYKDG-----------KRLKNYNMPWGAGHNHCLGRSYAVNSIKQF-VFLV 8A2 5061 -QSFKYDRFLNIDMSMKDTFYKNE-----------GRLKYYTMPWGAGRHACVGKEFAVATIKQF-VFFI 8A1 4451 -QKYKFNRFLNEDGSVKKDFYKGG-----------RRLKYYSMPWGAGANGCVGKQFAISTMKQY-IYVL 8B1 -TVFKYDRFLNPNGSRKVDFFKTG-----------KKIHHYTMPWGSGVSICPGRFFALSEVKLF-ILLM 8B1 7782 -RSFKYDRFLNPDGSKKTDFYKAG-----------NKVKYYTMPWGSGISMCPGRFFATNELKQF-AFLM 8B2 21917-RSFKYDRFLNPDGSKKTDFYKAG-----------NKVKYYTMPWGSGASMCPGRFFATNELKQF-AFLM 7B1 -EEFRYDRFIED-GKKKTTFFKRG-----------KKLKCYLMPFGTGTSKCPGRFFALMEIKQL-LVIL 7A1 -LTFKYDRYLDENGKTKTTFYCNG-----------LKLKYYYMPFGSGATICPGRLFAIHEIKQF-LILM 7A1 5172 -YEYKFDRFLDENNQEKTTFTRNG-----------RKLRYFYMPFGSGVTKCPGRFFAVYEIKQF-LTLV 7C1 16085-QTFQFDRYVQDSKGGFFKGG--------------QRLKYYLMPFGSGSSMCPGRHFAVNEIKQF-LCLM 39A1 -ELFKPERWEKGKFRRKH-----------------SFLGTASWAFGAGSSQCPGKVFALLEVQMC-IILI 51 -LDFNPDRYLQDNPA--------------------SGEKFAYVPFGAGRHRCIGENFAYVQIKTI-WSTM 51 437 -LEFKPDRYLDDNPA--------------------AGEKFAYIPFGAGRHRCIGENFAYVQIKTI-WSTL 2C9 LQNF-NLKSLVDPKNLDTTPVVNGFASVPPFYQLCFI-PV*-------------------------- 2C19 LQNF-NLKSLIDPKDLDTTFVVNGFASVPPFYQLCFI-PV*-------------------------- 2C18 LQNF-NLKSQVDPKDIDITPLPMHLVGVPPLYQLCFI-PV*-------------------------- 2C8 LQNF-NLKSVDDLKNLNTTAVTKGIVSLPPSYQICFI-PV*-------------------------- 2E1 LQHF-NLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVI-PRS*------------------------- 2F1 LQSF-SLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLR-PR*-------------------------- 2W1 LQRYRLLPPPGSPASLDTTP-ARAFTMRPRPRALCAV-PRP*------------------------- 2B6 LQNF-SMASPVAPEDIDLTPQECGVGKIPPTYQIRFL-PR*-------------------------- 2A6 MQNF-RLKSSQSPKDIDVSPKHVGFATIPRNYTMSFL-PR*-------------------------- 2A7 MQNF-RLKSSQSPKDIDVSSKHVGFATIPRNYTMSFL-PR*-------------------------- 2A13 MQNF-RFKSPQSPKDIDVSPKHVGFATIPRNYTMSFL-PR*-------------------------- 2G1P LQNF-SLCSLVPLVDIDITPKLSGFGNITPTYELCLV-AR*-------------------------- 2G2P LQNF-SLHSLVPPVDIDITPKLSGFGNIPPTYELCLV-AR*-------------------------- 2M1 troutLQRF-TFTGTKPPEEINIEPACSSFGRLPRSYDCYIK-LRTEK*----------------------- 2J2 MQKF-TFRPPNNEKLSLKFRM--GITISPVSHRLCAV-PQV*------------------------- 2X2 4007LHKF-QFIWPEDAGEPDYTPIF-GATQTPKPYRMKIQ-LRK*------------------------- 2X3 LRKF-RFIWPEDAEEPDLTPVF-GVTQTPKPYSLKVQ-VRSRC*----------------------- 2X1catfishLRRF-QFIWPEDAGEPDFTPIF-GLTLTPKPYRMGVK-LRQPAREK*-------------------- 2V1 DanioLQSF-SLSAPDETQTSLDFKC--GMTLSPKPFKICFT-PR*-------------------------- 2Z2 2993bMQHF-TFSMPAGVK-PDMSFRF-GVTLAPKPYEICAI-PR*-------------------------- 2P3 killiLQRF-TFSAPAGEE-PSLEFKL-GATRSPKPYRLCAT-PR*-------------------------- 2P4 LQRF-SFSMADGEQPSLDFQLG-GARFPKPYRLRAIL-R*--------------------------- 2N2 killiLQKF-TFSVPEGVE-LSTEGIT-GTTRVPHPYKVSAK-IR*-------------------------- 2N11 3261cFQKF-SYSVSGGAELSTEGIT--GITRVPHPFEIHTR-PRSF*------------------------ 2N10 3261bFQNF-TFFVPGGAELNTEGIT--GTTRVPHPFEILAR-PR*-------------------------- 2N12 3261dLQHF-NLSPVPGQMPSLEGIL--GFTYSPQPFRMIVA-PR*-------------------------- 2N9 3261aCQRF-HFSTLDRVELSTEGIT--GATRTPYPFKIYAQ-VR*-------------------------- 2Y2 39b LKDF-TFSCIEGPDSISLNPQYSGFANLPRNYEIVAT-PR*-------------------------- 2R1 7138 LQRF-HLQFPVGTIPTIAPKL--GMTLQPKPYSICAV-RRHQKSLISVTTPCHK*------------ 2U1 8899 LQTF-HFRLPEGAPRPPLQGRF-GLTLAPCPYTVCIN-PR*-------------------------- 2U1 MQSF-AFALPEDSKKPLLTGRF-GLTLAPHPFNITIS-RR*-------------------------- 2Z1 2993aMQDF-TISFPAGVSP-AMEYHHFGVTLAPHPFDICAV-SR*-------------------------- 2K9 12487LQHF-RFKPAGVSDSLDLTPVV-GITLNPLTHKLRAI-SRF*------------------------- 2K6 DanioLQYF-RFTPPGVSEDDLDLTPVVGFTLNPKPHQLCAV-KRS*------------------------- 2Y1 39a VQHF-TLSCPGGPDSVDLTPEYSSFANVPRKYKIIAT-PRWQ*------------------------ 2K10 19693LQQF-RFTPGVGEDELDLTPVVG-FTLSPSPHKLCAI-PRQ*------------------------- 2K11 10791LQHF-RFRPGVSEDHLDLTPRVG-LTLNPSAHKLCAV-SCL*------------------------- 2R1 LQRF-HLHFPHELVPDLKPRL--GMTLQPQPYLICAE-RR*-------------------------- 2S1 LQAF-SLESPCPPDTLSLKPTVSGLFNIPPAFQLQVR-PTDLHSTTQTR*----------------- 2T2P LQRF-CLLPVVRPGTINLTQCT-GLGSVPPDFQLQPV-AC*-------------------------- 2D6 LQHF-SFSVPTG-QPRPSHHGVFAFLVSPSPYELCAV-PR*-------------------------- 1A1 LQRV-EFSVPLG-VKVDMTPIYGLTMKHACCEHFQMQ-LRS*------------------------- 1A2 LQQL-EFSVPPG-VKVDLTPIYGLTMKHARCEHVQAR-LRFSIN*---------------------- 1B1 AHQC-DFRANPN-EPAKMNFSYGLTIKPKSFKVNVTL-RESMELLDSAVQNLQAKETCQ*------- 1B2 3008aLHQC-SFESSAD-EDLTLNCSYGLTLKPLDFSITAKL-RGKLLKSP*-------------------- 1B3 3008bLHQC-SFESDPS-DPLTLDCSYGLTLKPLRCFVSAKP-RGKLLGLVSPA*----------------- 1B1 1553 GHQC-HITDDPA-KPTTMDYNYGLTLKPRGFYVALTL-RGDMRLLDEAASRPPAEEPGRGPLADP*- 17 LQRF-DLEVPDD-GQLPSLEGIPKVVFLIDSFKVKIK-VRQAWREAQAEGST*-------------- 17A1 4175 LQRF-TLTVPSG-HSLPSLEGKFGVVLQPTKYKVNAT-PRPGWEGKCKACWN*-------------- 17A2 8086 LQRM-SFRLPNG-ASPPDLQGRMGVVLQPVPYKVVVT-PRVG*------------------------ 21 LQAF-TLLPSGD-ALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ*--------------- 21 15 LRDF-CFVLPDS-EAPLPDLRGVASVVLKIKSFTVIARPRTGP*----------------------- 3A4 LQNF-SFKPCKE-TQIPLKLSLGGLLQ-PEKPVVLKVESRDGTVSGA*------------------- 3A5 LQNF-SFKPCKE-TQIPLKLDTQGLLQ-PEKPIVLKVDSRDGTLSGE*------------------- 3A7 LQNF-SFKPCKE-TQIPLKLRFGGLLL-TEKPIVLKAESRDETVSGA*------------------- 3A43 LQNF-SFKPCKE-TQIPLKLDNLPILQ-PEKPIVLKVHLRDGITSGP*------------------- 3A47 600 LQKY-SFSVCKE-TEIPFKMDPNTFVG-PINPIKLRVVRR*-------------------------- 3B1 2213aLQSY-TVETCKD-TMIPLEFDWKS--Q-PLKPIKLSFIPRQK*------------------------ 3B2 2213bLQSY-TVETCKD-TMIPLEFDWKL--Q-PTKQIKLRLVPRQK*------------------------ 3A48 LQHY-SFVPCKE-TDIPMVLNTEGLVA-PKNPIKLKLKPRAV*------------------------ 3A49 LQHY-SFVTCPE-TDIPMVLGNEGFVT-PKNPIKLKLKLRDVSN*---------------------- 3A50P LQHF-SFVACKE-TMIPMVLDDNGFVH-PKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN 3A27 troutLQSF-TFSVCDE-TEIPLEMDNQGLLM-PKRPIKLRLEARRNTPSNTTATTLKSPTT*--------- 5A1 LHKF-RFQACPE-TQVPLQLESKSALG-PKNGVYIKIVSR*-------------------------- 5A1 1244 FRRF-NLLACTE-TKVPLELKSSSTLG-PKNGVFVKIERRHWDESQVNSPSED*------------- 4A11 LLRF-ELLP--DPTRIPI-PIARLVLK-SKNGIHLRLRRLPNPCEDKDQL*---------------- 4A22 LLRF-ELLP--DPTRIPI-PMARLVLK-SKNGIHLRLRRLPNPCEDKDQL*---------------- 4A20 LLRF-KLAP--DHSRPPQ-PVRQVVLK-SKNGIHVFAKKV*-------------------------- 4B1 LLRF-EFSL--DPSRLPI-KMPQLVLR-SKNGFHLHLKPLGPGSGK*-------------------- 4F2 LLAF-RVLP--DHTEPRRSRSWSCAQR-ADFGCGWSP*----------------------------- 4F3 LLAF-RVLP--DHTEPRR-K-PELVLR-AEGGLWLRVEPLS*------------------------- 4F8 LLRF-RILP--DHREPRR-T-PEIVLR-AEDGLWLRVEPLG*------------------------- 4F11 LLHF-RILP--THIEPRR-K-PELILR-AEGGLWLRVEPLGANSQ*--------------------- 4F12 LLHF-RFLP--DHTEPRR-K-LELIMR-AEGGLWLRVEPLNVSLQ*--------------------- 4F22 LLRF-RLSV--DRTRKVR---PELILR-TENGLWLKVEPLPPRA*---------------------- 4F28 2425 LLRF-RLLP--GNDPKRET--PFEKVR-AEGGLWLQIKPVTQTQ*---------------------- 4X1 LLHF-RVTP--DPTRPLT-FPNHFILK-PKNGMYLHLKKL*-------------------------- 4V2 LRHF-WIES--NQKREELGLEGQLILR-PSNGIWIKLKRRNADER*--------------------- 4V5 485 LRKF-NVEA--CQKREELRPVGELILR-PEKGIWIKLEKRKPLIPPS*------------------- 4T5 8637 LLKY-ELLE--EPTLKPKIIPR-LVLR-SLNGIHIKIKNANQN*----------------------- 4T2seabassLKKY-HLIE--DPNWKPKIIPR-LVLR-SLNGIHIKIKPVDPQV*---------------------- 46 LQRL-EFRL--VPGQRF-GLQEQATLK-PLDPVLCTLRPRGWQPAPPPPPC*--------------- 46 4537 IQRF-DFTL--LPGQSF-DILDNGTLR-PKSGVLCSLRHRDHKK*---------------------- 20 VKRL-HLLS--VEGQVI--ETKYELVT-SSREEAWITVSKRY*------------------------ 20 486 VRQL-KLHR--LKDTLM--EVRSELVS-TPRDETWITFNLRN*------------------------ 26A1 ARHC-DWQL---LNGPPT-MKTSPTVY-PVDNLPARFTHFHGE*----------------------- 26A1 12575VTKC-HWSL---LNGPPT-MKTGPTVY-PVDNLPTKFNTYVQN*----------------------- 26B1 4267 ASTS-RFELA--TRQFPR-VITVPVVH-PVDGLKVKFYGLDSNQNEIMAKSEELLGAAV*------- 26C1 11741IRTC-KWTLA--TEKFPK-MQTVPIVH-PVNGLHVNFMYKNLHEIDH*------------------- 26B1 ASTS-RFELA--TRTFPR-ITLVPVLH-PVDGLSVKFFGLDSNQNEILPETEAMLSATV*------- 26C1 VRTA-RWELA--TPAFPA-MQTVPIVH-PVDGLRLFFHPLTPSVAGNGLCL*--------------- 11A1 LENF-RVEIQ-HLSDVG-TTFNLILM--PEKPISFTFWPFNQEATQQ*------------------- 11A1 1630 LENF-RVEKQ-RHMEVQ-STFELILL--PDKPIILTLKPLSS*------------------------ 11B1 LKNF-LVETL-EQEDIK-MVYRFILM--PSTLPLFTFRAIQ*------------------------- 11B2 LKHF-LVETL-TQEDIK-MVYSFILR--PGTSPLLTFRAIN*------------------------- 11B1 fugu LLGF-DLSVP-SSEDIK-TMCTLILM--PETPPKITFTKL*-------------------------- 27A1 IQKY-KVVLAPETGELK-SVARIVLV--PNKKVGLQFLQRQ*------------------------- 27A1 3437 MRHF-EIKPDPKMGELK-SVCRTVLI--PDKPVSLRFLDRGSGHAA*-------------------- 27A2 697 ------------------------------------------------------------------- 27A3 IRRF-EVRPDPNGAEVK-PITRTLLC--PATPINLQFLDRGAQRAPGPAAGASL*------------ 27B1 LTHF-EVQPEPGAAPVR-PKTRTVLV--PERSINLQFLDR*-------------------------- 27B1 470 LLEF-DIKPDPEGISVK-PMTRTLLV--PENVINLQFTER*-------------------------- 27C1 LQHF-EIKTSSQTNAVH-AKTHGLLT--PGGPIHVRFVNRK*------------------------- 27C1 1410 IQKF-HVCVSPLTTDVK-AKTHGLLC--PGAPINLQFIDREI*------------------------ 24 VRKY-DIQAT-DNEPVE-MLHSGTLV--PSRELPIAFCQR*-------------------------- 24 1804 VRDF-EIVAT-DNEPLD-VIHSGLLV--PNRELPVAFIKR*-------------------------- 19 LRRF-HVKTLQGQCVESIQKIHDLSLH-PDETKNMLEMIFTPRNSDRCLEH*--------------- 19ov 7098 LSQY-SVCPHEGLTLDCLPQTNNLSQQ-PVEHQEEAQQLSMRFLPRQRGSWQTV*------------ 19br 4200 LSRY-TVCPRHGCTLTSIRQTNNLSQQ-PVEDEHSLAMRFIPRTIQSPS*----------------- 8A1 LVHL-DLELINAD--VEIPEFDLSRYGFGLMQPEHDVPVRYRIRP*--------------------- 8A2 5061 LTHF-DLETCDPQ--AKLPPVNPSRYGLGMLQPEGELQVRYRLKRSQPET*---------------- 8A1 4451 LTNY-DLELCDPC--ALMPGVNASRYGFGMLQPEGDLLVRYRPRQKL*------------------- 8B1 VTHF-DLELVDPD--TPLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE*------------------- 8B1 7782 LLYF-EFELINPD--EEIPEIDYSRYGFGTMQPDRDLQFRYRLRY*--------------------- 8B2 21917LLYF-EFELINPD--EEIPEIDYSRYGFGTMQPDRDLQFRYRRRY*--------------------- 7B1 LTYF-DLEIIDDK---PIGLNY-SRLLFGIQYPDSDVLFRYKVKS*--------------------- 7A1 LSYF-ELELIEGQ--AKCPPLDQSRAGLGILPPLNDIEFKYKFKHL*-------------------- 7A1 5172 LTYF-DMELLDPA--IQVPPLDQSRAGLGILQPTYDVDFRYKLKLAY*------------------- 7C1 16085LLYF-NLEL-EPG--QTRATVDSSRAGLGILFPSAKVHFRYRLRCV*-------------------- 39A1 LYKY-DCSLLDP-LPKQSYLHLVGVPQPEGQCRIEYKQRI*-------------------------- 51 LRLY-EFDLIDG-YFPTV-NYTTMIHTPENPVIRYKRRSK*-------------------------- 51 437 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