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Alignment of 60 human sequences including four pseudogenes This alignment is not perfect and could be revised (April 10, 2001) D. Nelson revised to add missing exons of 27C1. Added 26C1, 2W1, 20 2C9 human -------------------------MDS------------ 2C19 human -------------------------MDP------------ 2C18 human -------------------------MVP------------ 2C8 human -------------------------MEP------------ 2E1 human -------------------------MFALGV--------- 2F1 human -------------------------MDSI----------- 2W1 human -------------------------MALL----------- 2B6 human -------------------------MELS----------- 2A6 human -------------------------MLASGML-------- 2A7 human -------------------------MLASGLL-------- 2A13 human -------------------------MLASGLL-------- 2G1P human -------------------------MELGGAV-------- 2G2P human -------------------------MEMGGAV-------- 2J2 human -----------------------MLAAMGSLAAALWAVVH 2R1 human -------------------------MWKLWRAEEGAAA-- 2S1 human -------------------------MEATGT--------- 2T2P human ---------------------------------------- 2T3P human ---------------------------------------- 2U1 human -------MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPS 2D6 human ----------------------------MGLEALV----- 1A1 human ----------------------MLFPISMSATEFL----- 1A2 human --------------------MALSQSVPFSATELL----- 1B1 human -----------MGTSLSPNDPWPLNPLSIQQTTLL----- 17 human ---------------------------------------- 21 human ---------------------------------------- 3A4 human -------------------------MAVIPDLAME----- 3A5 human -------------------------MDLIPNLAVE----- 3A7 human -------------------------MDLIPNLAVE----- 3A43 human -------------------------MDLIPNFAME----- 5A1 human -------------------MEALGFLKLEVNGPMV----- 4A11 human -------------------------MSVSVLSPSRLLGD- 4A20 human -------------------------MEPSWLQEL------ 4B1 human -------------------------MVPSFLSLS------ 4F2 human -----------------------MSQLSLSWLGLCDVAAS 4F3 human -----------------------MPQLSLSSLGLWPMAAS 4F8 human -----------------------MSLLSLSWLGLRPVAAS 4F11 human -----------------------MPQLSLSWLGLGPVAAS 4F12 human -----------------------MSLLSLPWLGLRPVAMS 4F22 human ---------------------MLPITDRLLHLLGLEKTAF 4X1 human -------------------------MEFSWLETRWAR--- 4V2 human -------------------------MAGLWLGLVWQK--- 46 human -------------------------MSPGLLLLGSA---- 20 human ---------------------------------------- 26A1 human -------------------------MGLPALLA------- 26B1 human -------------------------MLFEGLDLVSA---- 26C1 human -------------------------MFPWGLSCLSV---- 11A1 human --------------------------MLAKGLPPRSVLVK 11B1 human --------------------------MALRA--------- 11B2 human --------------------------MALRA--------- 27A1 human ---------------MAALGCARLRWAL---RGAGRGLCP 27B1 human ---------------MTQTLKYASRVF------------- 27C1 human ----MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQ 24 human ---------------MSSPISKSRSLAAFLQQLRSPRQPP 19 human --------------------------MVLE---------- 8A1 human -------------------------MAW------------ 8B1 human ---------------------------------------- 7B1 human ------------------------MAGEVSAATGRFSLER 7A1 human --------------------------MMTTSLI---WGIA 39A1 human --------------------------MELISPT---VIII 51 human -------------MAAAAGMLLLGLLQAG-GSVLGQ---- 2C9 ---LVV-LVLCLSCLL--L-LSLWR-------------QSSGRGKLPPGPTPL-PVIGNI--LQIGIKDI 2C19 ---FVV-LVLCLSCLL--L-LSIWR-------------QSSGRGKLPPGPTPL-PVIGNI--LQIDIKDV 2C18 ---AVA-LVLCLSCLF--L-LSLWR-------------QSSGRGRLPSGPTPL-PIIGNI--LQLDVKDM 2C8 ---FVV-LVLCLSFML--L-FSLWR-------------QSCRRRKLPPGPTPL-PIIGNM--LQIDVKDI 2E1 ---TVA-LLVWAAFLL--L-VSMWR-------------QVHSSWNLPPGPFPL-PIIGNL--FQLELKNI 2F1 ---STA-ILLLLLALV--C-LLLTL-------------SSRDKGKLPPGPRPL-SILGNL--LLLCSQDM 2W1 ---LLL-FLGLLGLWG--L-LCACA------------QDPSPAARWAPGLRPL-PLVGNL--HLLRLSQQ 2B6 ---VLL-FLALLTGLL--L-LLVQR-------------HPNTHDRLPPGPRPL-PLLGNL--LQMDRRGL 2A6 ---LVA-LLVCLTVMV--L-MSVWQ-------------QRKSKGKLPPGPTPL-PFIGNY--LQLNTEQM 2A7 ---LVA-LLACLTVMV--L-MSVWQ-------------QRKSKGKLPPGPTPL-PFIGNY--LQLNTEHI 2A13 ---LVT-LLACLTVMV--L-MSVWR-------------QRKSRGKLPPGPTPL-PFIGNY--LQLNTEQM 2G1P ---TIF-LALRLSCLL--I-LIAWK-------------RMDKAGKLPPGPTPI-LFLGHL--LQVRTDAT 2G2P ---TIF-LALCLSCLL--I-LIAWK-------------*MNKAGKLPPGPTPI-PFLGNL--LQVRTDAT 2J2 ---PRT-LLLGTVAFL--L-AADFL-------------KRRRPKNYPPGPWRL-PFLGNF--FLVDFEQS 2R1 ---LGG-ALFLLLFAL--G-VRQLL-------------KQRRPMGFPPGPPGL-PFIGNI--YSLAASSE 2S1 ---WAL-LLALALLLL--L-TLALS-------------GTRARGHLPPGPTPL-PLLGNL--LQLRPGAL 2T2P --------------------------------------RAQMRGSLPPRPRPL-PLLGNL---QLQSGGL 2T3P --------------------------------------RAQMRGSLPPRPRLL-PLLGNL---QLQSGGL 2U1 ---GGA-LLLCGLVAL--L-GWSWL-------------RRRRARGIPPGPTPW-PLVGNF---GHVLLPP 2D6 ---PLA-VIVAIFLLL--V-DLMHR-------------RQRWAARYPPGPLPL-PGLGNL--LHVDFQNT 1A1 ---LAS-VIFCLVFWV--I-RASRP-------------QVPKGLKNPPGPWGW-PLIGHM--LTLG-KNP 1A2 ---LAS-AIFCLVFWV--L-KGLRP-------------RVPKGLKSPPEPWGW-PLLGHV--LTLG-KNP 1B1 ---LLL-SVLATVHVG--Q-RLLRQ-------------RRRQLRSAPPGPFAW-PLIGNA--AAVG-QAA 17 --MWEL-VALLLLTLA--Y-LFWPK-------------RRCPGAKYPKSLLSL-PLVGSL-PFLPRHGHM 21 -----M-LLLGLLLL---P-LLAGA------------RLLWNWWKLRSLHLP-PLAPGFL--HLLQPDL- 3A4 --TWLL-LAVSLVLLY--L-YGTHS-------------HGLFKKLGIPGPTPL-PFLGNI--LSY-HKGF 3A5 --TWLL-LAVSLVLLY--L-YGTRT-------------HGLFKRLGIPGPTPL-PLLGNV--LSY-RQGL 3A7 --TWLL-LAVSLILLY--L-YGTRT-------------HGLFKKLGIPGPTPL-PFLGNA--LSF-RKGY 3A43 --TWVL-VATSLVLLY--I-YGTHS-------------HKLFKKLGIPGPTPL-PFLGTI--LFY-LRGL 5A1 --TVAL-SVALLALLK--W-YSTSA-------------FSRLFKLGLRHPKPS-PFIGNL--TFF-RQGF 4A11 VSGILQ-AASLLILLLLL----IKAVQLYLHRQ-----WLLKALQQFPCPPSH-WLFGHIQELQQD-QEL 4A20 MAHPFL-LLILLCMSLLL----FQVIRLYQRRR-----WMIRALHLFPAPPAH-WFYGHKEFYPVK-EFE 4B1 FSSLGL-WASGLILVLGF----LKLIHLLLRRR-----TLAKAMDKFPGPPTH-WLFGHALEIQET-GSL 4F2 --PWLL-LLLVGASWLLA----HVLAWTYAFYD-----NCRRLRCFPQPPRRN-WFWGHQGMVNPTEEGM 4F3 --PWLL-LLLVGASWLLA----RILAWTYTFYD-----NCCRLRCFPQPPKRN-WFLGHLGLIHSSEEGL 4F8 --PWLL-LLVVGASWLLA----RILAWTYAFYH-----NGRRLRCFPQPRKQN-WFLGHLGLVTPTEEGL 4F11 --PWLL-LLLVGGSWLLA----RVLAWTYTFYD-----NCRRLQCFPQPPKQN-WFWGHQGLVTPTEEGM 4F12 --PWLL-LLLVVGSWLLA----RILAWTYAFYN-----NCRRLQCFPQPPKRN-WFWGHLGLITPTEEGL 4F22 -RIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYI-----TCRRLRCFPQPPRRN-WLLGHLGMVSPNEAGL 4X1 --------PFYLAFVFCLALGLLQAIKLYLRRQ-----RLLRDLRPFPAPPTH-WFLGHQKFIQDDNMEK 4V2 ---LLLWGAASAVSLAGASLVLSLLQRVASYAR-----KWQQMRPIPTVARAY-PLVGHA--LLMKPDGR 46 --------------------VLLAFGLCCTFVH-----RARSRYEHIPGPPRPSFLLGHLPCFWKKDEVG 20 ----------MLDFAIFAVTFLLALVGAVLYLY-----PASRQAAGIPGITPTEEKDGNLP-DIVNSGSL 26A1 SALCTF-VLPLLLFLAAL----KLWDLYCVSSR-----DRSCALPLPPGTMGF-PFFGET--LQM-VLQR 26B1 LATLAACLVSVTLLLAVS---QQLWQLRWAATR-----DKSCKLPIPKGSMGF-PLIGET--GHW-LLQG 26C1 LGAAGTALLCAGLLLSLA---QHLWTLRWMLSR-----DRASTLPLPKGSMGW-PFFGET--LHW-LVQ- 11A1 GYQTFL-SAPREGLGRLRVPTGEGAGIS-TRSP-----RPFNEIPS-PGDNGW-LNLYHF-WRETGTHKV 11B1 KAEVCM-AVPWLSLQRAQALGTRAARV--PRTV-----LPFEAMPR-RPGNRW-LRLLQI-WREQGYEDL 11B2 KAEVCV-AAPWLSLQRARALGTRAARA--PRTV-----LPFEAMPQ-HPGNRW-LRLLQI-WREQGYEHL 27A1 HGARAK-AAIPAALPSDKATGAPGAGPGVRRRQ-----RSLEEIPR-LGQ----LRFFFQ-LFVQGYAL- 27B1 -----------HRVRWAPELGASLGYREYHSAR-----RSLADIPG-PST----PSFLAE-LFCKGGLS- 27C1 -PAGARLPAGARAEDKGAGRPGSPPGGGRAEGP-----RSLAAMPG-PRT----LANLAE-FFCRDGFS- 24 RLVTST-AY-TSPQPREVPVCPLTAG-GETQN------AAALPGPT-SWPLLA-SLLQIL-WKGGLK--- 19 ---MLN-PIHYNITSIVPEAMPAATMSVLLLTGLFLLLWNYEGTSSIPGPGYC-MGIGPL--ISH-GRFL 8A1 --AALL-GLLAALLLLL----------LLSRRR-------TRRPGEPPLDLGSIPWLGYA--LDF-GKDA 8B1 -----------------------------------------------------VPWLGHA--MAF-RKNM 7B1 --LGLP-GLALAAALLLLALC------LLVRR--------TRRPGEPPLIKGWLPYLGVV--LNL-RKDP 7A1 IAACCC-LWL-----------------ILGIR--------RRQTGEPPLENGLIPYLGCA--LQF-GANP 39 ---LGC-LAL-----------------FLLLQ--------RKNLRRPPCIKGWIPWIGVG--FEF-GKAP 51 --AMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHA--IAF-GKSP 2C9 ----SKSLTNLSK--VYG------PVFTLYFGL-KPIVVLHGYEAVKEAL-IDLGEEFSG----------- 2C19 ----SKSLTNLSK--IYG------PVFTLYFGL-ERMVVLHGYEVVKEAL-IDLGEEFSG----------- 2C18 ----SKSLTNFSK--VYG------PVFTVYFGL-KPIVVLHGYEAVKEAL-IDHGEEFSG----------- 2C8 ----CKSFTNFSK--VYG------PVFTVYFGM-NPIVVFHGYEAVKEAL-IDNGEEFSG----------- 2E1 ----PKSFTRLAQ--RFG------PVFTLYVGS-QRMVVMHGYKAVKEAL-LDYKDEFSG----------- 2F1 ----LTSLTKLSK--EYG------SMYTVHLGP-RRVVVLSGYQAVKEAL-VDQGEEFSG----------- 2W1 ----DRSLMELSE--RYG------PVFTVHLGR-QKTVVLTGFEAVKEAL-AGPGQELAD----------- 2B6 ----LKSFLRFRE--KYG------DVFTVHLGP-RPVVMLCGVEAIREAL-VDKAEAFSG----------- 2A6 ----YNSLMKISE--RYG------PVFTIHLGP-RRVVVLCGHDAVREAL-VDQAEEFSG----------- 2A7 ----CNSIMKFSE--CYG------PVFTIHLGP-RRVVVLCGHDAVREAL-VDQAEEFSG----------- 2A13 ----YNSLMKISE--RYG------PVFTIHLGP-RRVVVLCGHDAVKEAL-VDQAEEFSG----------- 2G1P ----FQSFMKLRE--KYS------PVFTVYMGP-RPVVVLCGHEAVKEAL-IDQADEFSG----------- 2G2P ----FQSFMKLRE--KYS------PVFTVYMGP-RPVVVLCGHEAVKEAL-VDQADEFSG----------- 2J2 ----HLEVELFVK--KYG------NLFSLELGD-ISAVLITGLPLIKEAL-IHMDQNFGN----------- 2R1 --LPHVYMRKQSQ--VYG------EIFSLDLGG-ISTVVLNGYDVVKECL-VHQSEIFAD----------- 2S1 ----YSGLMRLSK--KYG------PVFTIYLGPWRPVVVLVGQEAVREAL-GGQAEEFSG----------- 2T2P ----DRALHSLSG--RWG------RVFTVRLGP-RPAVGLCGYAALRDAL-VLQADAVSG----------- 2T3P ----DRALHSLSG--RWG------RVFTVRLGP-RPAVVLCGYAALRDAL-VLQADAVSG----------- 2U1 ----QVLLAHLAR--VYG------SIFSFFIGH-YLVVVLSDFHSVREAL-VQQAEVFSD----------- 2D6 ----PYCFDQLRR--RFG------DVFSLQLAW-TPVVVLNGLAAVREAL-VTHGEDTAD----------- 1A1 ----HLALSRMSQ--QYG------DVLQIRIGS-TPVVVLSGLDTIRQAL-VRQGDDFKG----------- 1A2 ----HLALSRMSQ--RYG------DVLQIRIGS-TPVLVLSRLDTIRQAL-VRQGDDFKG----------- 1B1 ----HLSFARLAR--RYG------DVFQIRLGS-CPIVVLNGERAIHQAL-VQQGSAFAD----------- 17 ----HNNFFKLQK--KYG------PIYSVRMGT-KTTVIVGHHQLAKEVL-IKKGKDFSG----------- 21 ----PIYLLGLTQ--KFG------PIYRLHLGL-QDVVVLNSKRTIEEAM-VKKWADFAG----------- 3A4 ----CMFDMECHK--KYG------KVCGFYDGQ-QPVLAITDPDMIKTVL-VK--ECYSV----------- 3A5 ----WKFDTECYK--KYG------KMWGTYEGQ-LPVLAITDPDVIRTVL-VK--ECYSV----------- 3A7 ----WTFDMECYK--KYR------KVWGIYDCQ-QPMLAITDPDMIKTVL-VK--ECYSV----------- 3A43 ----WNFDRECNE--KYG------EMWGLYEGQ-QPMLVIMDPDMIKTVL-VK--ECYSV----------- 5A1 ----WESQMELRK--LYG------PLCGYYLGR-RMFIVISEPDMIKQVL-V---ENFSN----------- 4A11 ----QRIQKWVET--TFP------SACPHWLWGGKVRVQLYDPDYMKVIL-GR--SDPKS----------- 4A20 -----VYHKLME---KYP------CAVPLWVGPFTMFFSVHDPDYAKILL-KR--QDPKS----------- 4B1 ----DKVVSWAH---QFP------YAHPLWFGQFIGFLNIYEPDYAKAVY-SR--GDPKA----------- 4F2 ----RVLTQLVA---TYP------QGFKVWMGPISPLLSLCHPDIIRSVI-NA--SAAIA----------- 4F3 ----LYTQSLAC---TFG------DMCCWWVGPWHAIVRIFHPTYIKPVL-FA--PAAIV----------- 4F8 ----RVLTQLVA---TYP------QGFVRWLGPITPIINLCHPDIVRSVI-NT--SDAIT----------- 4F11 ----KTLTQLVT---TYP------QGFKLWLGPTFPLLILCHPDIIRPIT-SA--SAAVA----------- 4F12 ----KNSTQMSA---TYS------QGFTIWLGPIIPFIVLCHPDTIRSIT-NA--SAAIA----------- 4F22 ----QDEKKVLD---NMH------HVLLVWMGPVLPLLVLVHPDYIKPLL-GA--SAAIA----------- 4X1 ----LEEIIE-----KYP------RAFPFWIGPFQAFFCIYDPDYAKTLL-SR--TDPKS----------- 4V2 EFFQQIIEYTEEY--RHM------PLLKLWVGPVPMVALYNAENVEGILT-SS--KQIDK----------- 46 GRVLQDVFLDWAK--KYG------PVVRVNVFHKTSVIVTSPESVKKFLM-ST--KYNKD----------- 20 ----HEFLVNLHE--RYG------PVVSFWFGRRLVVSLGTVDVLKQHIN-PN--KTSDP----------- 26A1 ----RKFLQMKRR--KYG------FIYKTHLFG-RPTVRVMGADNVRRIL-LG--DDRLVS---------- 26B1 ----SGFQSSRRE--KYG------NVFKTHLLG-RPLIRVTGAENVRKIL-MG--EHHLVS---------- 26C1 ----------------------------------------------------------------------- 11A1 ----HLHHVQNFQ--KYG------PIYREKLGN-VESVYVIDPEDVAL-L-FKSEGP-------------- 11B1 ----HLEVHQTFQ--ELG------PIFRYDLGG-AGMVCVMLPEDVEK-L-QQVDSL-------------- 11B2 ----HLEMHQTFQ--ELG------PIFRYNLGG-PRMVCVMLPEDVEK-L-QQVDSL-------------- 27A1 --QLHQLQVLYKA--KYG------PMWMSYLGP-QMHVNLASAPLLEQ-V-MRQEGK-------------- 27B1 --RLHELQVQGAA--HFG------PVWLASFGT-VRTVYVAAPALVEE-L-LRQEGP-------------- 27C1 --RIHELQQKHTR--EYG------KIFKSHFGP-QFVVSIADRDMVAQ-V-LRAEGA-------------- 24 --KQHDTLVEYHK--KYG------KIFRMKLGS-FESVHLGSPCLLEA-L-YRTESV-------------- 19 --WMGSRSACNYYNRVYGE-----FMRVWISGE-ETLIISKSSSMFHIMK-HNHYSSRFG----------- 8A1 ----ASFLTRMKE--KHG------DIFTILVGG-RYVTVLLDPHSYDAVV-WEPRTRL------------- 8B1 ----FEFLKRMRT--KHG------DVFTVQLGG-QYFTFVMDPLSFGP-I-LK--DTQRKL---------- 7B1 ----LRFMKTLQK--QHG------DTFTVLLGG-KYITFILDPFQYQL-V-IK--NHKQLS---------- 7A1 ----LEFLRANQR--KHG------HVFTCKLMG-KYVHFITNPLSYHK-V-LC--HGKYFD---------- 39 ----LEFIEKARI--KYG------PIFTVFAMG-NRMTFVTEEEGINVFL-KSKKVDF------------- 51 ----IEFLENAYE--KYG------PVFSFTMVG-KTFTYLLGSDAAALLF-NSKNEDLNA----------- 2C9 -----RGI-FPLAERANR-------GFG-IVFS--NGKKWKEIRRFSLMTLRNFGMGK---------RSIE 2C19 -----RGH-FPLAERANR-------GFG-IVFS--NGKRWKEIRRFSLMTLRNFGMGK---------RSIE 2C18 -----RGS-FPVAEKVNK-------GLG-ILFS--NGKRWKEIRRFCLMTLRNFGMGK---------RSIE 2C8 -----RGN-SPISQRITK-------GLG-IISS--NGKRWKEIRRFSLTTLRNFGMGK---------RSIE 2E1 -----RGD-LPAF-HAHR-------DRG-IIFN--NGPTWKDIRRFSLTTLRNYGMGK---------QGNE 2F1 -----RGD-YPAFFNFTK-------GNG-IAFS--SGDRWKVLRQFSIQILRNFGMGK---------RSIE 2W1 -----RPP-IAIFQLIQR-------GGG-IFFS--SGARWRAARQFTVRALHSLGVGR---------EPVA 2B6 -----RGK-IAMVDPFFR-------GYG-VIFA--NGNRWKVLRRFSVTTMRDFGMGK---------RSVE 2A6 -----RGE-QATFDWVFK-------GYG-VVFS--NGERAKQLRRFSIATLRDFGVGK---------RGIE 2A7 -----RGE-QATFDWVFK-------GYG-VAFS--NGERAKQLLRFAIATLRDFGVGK---------RGIE 2A13 -----RGE-QATFDWLFK-------GYG-VAFS--NGERAKQLRRFSIATLRGFGVGK---------RGIE 2G1P -----RGE-LASIKQNFQ-------GHGGVALA--NGERWRILRRFSLTILRDFGMGK---------QSIK 2G2P -----RGE-LASIKQNFQ-------GHG-VALA--NGERWRIL*RFPLTILRDFGMGK---------RSIE 2J2 -----RPV-TPMREHIFK-------KNG-LIMS--SGQAWKEQRRFTLTALRNFGLGK---------KSLE 2R1 -----RPC-LPLFMKMTK-------MGG-LLNS-RYGRGWVDHRRLAVNSFRYFGYGQ---------KSFE 2S1 -----RGT-VAMLEGTFD-------GHG-VFFS--NGERWRQLRKFTMLALRDLGMGK---------REGE 2T2P -----RGS-MAVFERFTR-------GNG-ILFS--NRPCWWTLRNFALGALKKFGLGT---------RTVE 2T3P -----RGS-MAVFERFTR-------GNG-ILFS--NRPCWWTLRNFALGAPKKFGLDT---------RTIE 2U1 -----RPR-VPLISIVT-------------------GPVWRQQRKFSHSTLRHFGLGK---------LSLE 2D6 -----RPP-VPITQILGFGPR----SQG-VFLAR-YGPAWREQRRFSVSTLRNLGLGK---------KSLE 1A1 -----RPD-LYTFTLISN-------GQS-MSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTS--CYLE 1A2 -----RPD-LYTSTLITD-------GQS-LTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSS--CYLE 1B1 -----RPA-FASFRVVSG-------GRS-MAFG-HYSEHWKVQRRAAHSMMRNFFTRQPRSR-----QVLE 17 -----RPQ-MATLDIASNN------RKG-IAFA-DSGAHWQLHRRLAMATFALFKDGD---------QKLE 21 -----RPE-PLTYKLVSKN------YPD-LSLG-DYSLLWKAHKKLTRSALLLGIRDS-----------ME 3A4 -----FTN-RRPFGPVGFM------KSA-ISIA--EDEEWKRLRSLLSPTFTSGKLKE-----------MV 3A5 -----FTN-RRSLGPVGFM------KSA-ISLA--EDEEWKRIRSLLSPTFTSGKLKE-----------MF 3A7 -----FTN-RRPFGPVGFM------KNA-ISIA--EDEEWKRIRSLLSPTFTSGKLKE-----------MV 3A43 -----FTN-QMPLGPMGFL------KSA-LSFA--EDEEWKRIRTLLSPAFTSVKFKE-----------MV 5A1 -----FTN-RMASGLEFKSV-----ADS-VLFL--RDKRWEEVRGALMSAFSPEKLNE-----------MV 4A11 -----HGS-YRFLAPWI--------GYG-LLLL--NGQTWFQHRRMLTPAFHYDILKP-----------YV 4A20 -----AVS-HKILESWV--------GRG-LVTL--DGSKWKKHRQIVKPGFNISILKI-----------FI 4B1 -----PDV-YDFFLQWI--------GRG-LLVL--EGPKWLQHRKLLTPGFHYDVLKP-----------YV 4F2 --PKDKFF-YSFLEPWL--------GDG-LLLS--AGDKWSRHRRMLTPAFHFNILKP-----------YM 4F3 --PKDKVF-YSFLKPWL--------GDG-LLLS--AGEKWSRHRRMLTPAFHFNILKP-----------YM 4F8 --DKDIVF-YKTLKPWL--------GDG-LLLS--VGDKWRHHRRLLTPAFHFNILKP-----------YI 4F11 --PKDMIF-YGFLKPWL--------GDG-LLLS--GGDKWSRHRRMLTPAFHFN-LKP-----------YM 4F12 --PKDNLF-IRFLKPWL--------GEG-ILLS--GGDKWSRHRRMLTPAFHFNILKS-----------YI 4F22 --PKDDLF-YGFLKPWL--------GDG-LLLS--KGDKWSRHRRLLTPAFHFDILKP-----------YM 4X1 -----QYL-QKFSPPLL--------GKG-LAAL--DGPKWFQHRRLLTPGFHFNILKA-----------YI 4V2 -----SSM-YKFLEPWL--------GLG-LLTS--TGNKWRSRRKMLTPTFHFTILED-----------FL 46 -----SKM-YRALQTVFGERLF---GQG-LVSE-CNYERWHKQRRVIDLAFSRSSLVS-----------LM 20 -----FET-MLKSLLRYQS------GGG-SVSE------NHMRKKLYENGVTDSLKSN-----------FA 26A1 -----VHW-PASVRTIL--------GSG-CLSN-LHDSSHKQRKKVIMRAFSREALEC-----------YV 26B1 -----TEW-PRSTRMLL--------GPN-TVSN-SIGDIHRNKRKVFSKIFSHEALES-----------YL 26C1 ----------------------------------------------------------------------- 11A1 -----NPE-RFLIPPWVAYHQYYQRPIG-VLLK--KSAAWKKDRVALNQEVMAPEATK-------NFLPLL 11B1 -----HPH-RMSLEPWVAYRQHRGHKCG-VFLL--NGPEWRFNRLRLNPEVLSPNAVQ-------RFLPMV 11B2 -----HPC-RMILEPWVAYRQHRGHKCG-VFLL--NGPEWRFNRLRLNPDVLSPKAVQ-------RFLPMV 27A1 -----YPV-RNDMELWKEHRDQHDLTYG-PFTT--EGHHWYQLRQALNQRLLKPAEAA-------LYTDAF 27B1 -----RPE-RCSFSPWTEHRRCRQRACG-LLTA--EGEEWQRLRSLLAPLLLRPQAAA-------RYAGTL 27C1 -----APQ-RANMESWREYRDLRGRATG-LISA--EGEQWLKMRSVLRQRILKPKDVA-------IYSGEV 24 ------PQ-RLEIKPWKAYRDYRKEGYG-LLIL--EGEDWQRVRSAFQKKLMKPGEVM-------KLDNKI 19 -----SKL-GLQ--CIGMH------EKG-IIFN-NNPELWKTTRPFFMKALSGPGLVR-----------MV 8A1 -------D-FHAYAIFLMERIF---DVQ------LPHYSPSDEKARMKLTLLHRELQA-----------LT 8B1 -------D-FGQYAKKLVLKVF---GYR------SVQGDHEMIHSASTKHLRGDGLKD-----------LN 7B1 -----FRV-FSNKLLEKAFSIS-----Q-LQKN--HDMNDELHLCYQF--LQGKSLDI-----------LL 7A1 -----WKK-FHFATSAKAFGHR-----S-IDPM--DGNTTENINDTFIKTLQGHALNS-----------LT 39 -----ELA-VQNIVYRTASIPK-----N-VFLA-LHEKLYIMLKGKMGTVNLHQFTGQ-----------LT 51 -----EDV-YSRLTTPVF-------GKG-VAYDV-PNPVFLEQKKMLKSGLNI-----------AHFKQHV 2C9 DRVQEEARCLVEELRKTKASPCD---------PTFIL-GCAPCNVICSIIF-------HKRF--DYKDQQF 2C19 DRVQEEARCLVEELRKTKASTCD---------PTFIL-GCAPCNVICSIIF-------QKRF--DYKDQQF 2C18 DRVQEEARCLVEELRKTNASPCD---------PTFIL-GCAPCNVICSVIF-------HDRF--DYKDQRF 2C8 DRVQEEAHCLVEELRKTKASPCD---------PTFIL-GCAPCNVICSVVF-------QKRF--DYKDQNF 2E1 SRIQREAHFLLEALRKTQGQPFD---------PTFLI-GCAPCNVIADILF-------RKHF--DYNDEKF 2F1 ERILEEGSFLLADVRKTEGEPFD---------PTFVL-SRSVSNIICSVLF-------GSRF--DYDDERL 2W1 DKILQELKCLSGQLDGYRGRPF----------PLALL-GWAPSNITFALLF-------GRRF--DYRDPVF 2B6 ERIQEEAQCLIEELRKSKGALMD---------PTFLF-QSITANIICSIVF-------GKRF--HYQDQEF 2A6 ERIQEEAGFLIDALRGTGGANID---------PTFFL-SRTVSNVISSIVF-------GDRF--DYKDKEF 2A7 ERIQEESGFLIEAIRSSHGANID---------PTFFL-SRTVSNVISSIVF-------GDRF--DYEDKEF 2A13 ERIQEEAGFLIDALRGTHGANID---------PTFFL-SRTVSNVISSIVF-------GDRF--DYEDKEF 2G1P ERIQEEASYLLEEFQKTK----------------------------------------------------- 2G2P ERIQEEASYLLEEFRKTKGAPID---------PIFLL-SRTVSNVISSVVF-------RSRF--DYEDKQF 2J2 ERIQEEAQHLTEAIKEENGQPFD---------PHFKI-NNAVSNIICSITF-------GERF--EYQDSWF 2R1 SKILEETKFFNDAIETYKGRPFD---------FKQLI-TNAVSNITNLIIF-------GERF--TYEDTDF 2S1 ELIQAEARCLVETFQGTEGRPFD---------PSLLL-AQATSNVVCSLLF-------GLRF--SYEDKEF 2T2P ARVLEEAACLLDEFQATIGAPFD---------PVRLL-DNAVSNVICSLVF-------GNRY--RYGDPEF 2T3P ARVLDEAACLLDEFQATIGAPFD---------PVRLL-GNAVSSVTCSCLR-------EPLW--LRGPGVP 2U1 PKIIEEFKYVKAEMQKHGEDPFC---------PFSII-SNAVSNIICSLCF-------GQRF--DYTNSEF 2D6 QWVTEEAACLCAAFANHSGRPFR---------PNGLL-DKAVSNVIASLTC-------GRRF--EYDDPRF 1A1 EHVSKEAEVLISTLQELMAGPGHFN-------PYRYV-VVSVTNVICAICF-------GRRY--DHNHQEL 1A2 EHVSKEAKALISRLQELMAGPGHFD-------PYNQV-VVSVANVIGAMCF-------GQHF--PESSDEM 1B1 GHVLSEARELVALLVRGSADGAFLD-------PRPLT-VVAVANVMSAVCF-------GCRY--SHDDPEF 17 KIICQEISTLCDMLATHNGQSID---------ISFPV-FVAVTNVISLICF-------NTSY--KNGDPEL 21 PVVEQLTQEFCERMRAQPGTPVA---------IEEEF-SLLTCSIICYLTF-------GDKI---KDDNLM 3A4 PIIAQYGDVLVRNLRRE-AETGKPVT------LKDVF-GAYSMDVITSTSF-------GVNI--DSLNNPQ 3A5 PIIAQYGDVLVRNLRRE-AEKGKPVT------LKDIF-GAYSMDVITGTSF-------GVNI--DSLNNPQ 3A7 PIIAQYGDVLVRNLRRE-AETGKPVT------LKHVF-GAYSMDVITSTSF-------GVSI--DSLNNPQ 3A43 PIISQCGDMLVRSLRQE-AENSKSIN------LKEDFFGAYTMDVITGTLF-------GVNL--DSLNNPQ 5A1 PLISQACDLLLAHLKRY-AESGDAFD------IQRCY-CNYTTDVVASVPF-------GTPV--DSWQAPE 4A11 GLMADSVRVMLDKWEELLGQDSP-------LEVFQHV-SLMTLDTIMKCAFSHQ----GSIQV-DRNSQSY 4A20 TMMSESVRMMLNKWEEHIAQNSR-------LELFQHV-SLMTLDSIMKCAFSHQ----GSIQL-DRSSYLK 4B1 AVFTESTRIMLDKWEEKAREGKS-------FDIFCDV-GHMALNTLMKCTFGRG----DTGLG-HRDSSYY 4F2 KIFNESVNIMHAKWQLLASEGSA------CLDMFEHI-SLMTLDSLQKCVFSFD----SHCQE-KPSEYIA 4F3 KIFNESVNIMHAKWQLLASEGSA------RLDMFEHI-SLMTLDSLQKCVFSFD----SHCQE-KPSEYIA 4F8 KIFSKSANIMHAKWQRLAMEGST------CLDVFEHI-SLMTLDSLQKCIFSFD----SNCQE-KPSEYIT 4F11 KIFNKSVNIMHDKWQRLASEGSA------RLDMFEHI-SLMTLDSLQKCVFSFE----SNCQE-KPSEYIA 4F12 TIFNKSANIMLDKWQHLASEGSS------CLDMFEHI-SLMTLDSLQKCIFSFD----SHCQE-RPSEYIA 4F22 KIFNQSADIMHAKWRHLAEGSAV------SLDMFEHI-SLMTLDSLQKCVFSYN----SNCQE-KMSDYIS 4X1 EVMAHSVKMMLDKWEKICSTQDT------SVEVYEHI-NSMSLDIIMKCAFSKE----TNCQT-NSTHDPY 4V2 DIMNEQANILVKKLEKHINQEAF--------NCFFYI-TLCALDIICETAMGKN----IGAQS-NDDSEYV 46 ETFNEKAEQLVEILEAK---------------ADGQT-PVSMQDMLTYTAMDIL----AKAAF-GMETSML 20 LLLKLSEELLDKWLSYPE------------TQHVPLS-QHMLGFAMKSVTQMVM---GSTF---EDDQEV 26A1 PVITEEVGSSLEQWLSCGERG---------LLVYPEV-KRLMFRIAMRILLGCEP---QLAG---DGDSEQ 26B1 PKIQLVIQDTLRAWSSHPEAI---------NVYQEAQ-KLTFRMAIRVLLGFSIP---EEDL---GHLFEV 26C1 ----------------------------------------------------------------------- 11A1 DAVSRDFVSVLHRRIKKAGSGNYS------GDISDDL-FRFAFESITNVIF-------GERQ---GMLEEV 11B1 DAVARDFSQALKKKVLQNARGSLT------LDVQPSI-FHYTIEASNLALF-------GERL---GLVGHS 11B2 DAVARDFSQALKKKVLQNARGSLT------LDVQPSI-FHYTIEASNLALF-------GERL---GLVGHS 27A1 NEVIDDFMTRLDQLRAESASGNQV------SDMAQLF-YYFALEAICYILF-------EKRI---GCLQRS 27B1 NNVVCDLVRRLRRQRGRGTGPPAL------VRDVAGE-FYKFGLEGIAAVLL------GSRL---GCLEAQ 27C1 NQVIADLIKRIYLLRSQAEDGETV------TNVNDLF-FKYSM-EGVATILY------ESRL---GCLENS 24 NEVLADFMGRIDELCDERGHV---------EDLYSEL-NKWSFESICLVLY-------EKRF---GLLQKN 19 TV----------CAESL-KTHLDRLE-------EVTN-ESGYVDVLTLLRRVMLD---TSNT--LFLRIPL 8A1 EAM--YTNLHAVLLGDATEAGS----------GWHEM-GLL-DFSYSFLL----------RA--GYLTLYG 8B1 ETM--LDSLSFVMLTSKGWSLD--------ASCWHED-SLF-RFCYYILF----------TA--GYLSLFG 7B1 ESMMQNLKQVFEPQLL---KTT----------SWDTA-ELY-PFCSSIIF----------EI--TFTTIYG 7A1 ESMMENLQRIMRPPVSSNSKTA----------AWVTE-GMY-SFCYRVMF----------EA--GYLTIFG 39 EELHEQLENLGTHGTMDLNNLV----------RHLLY-PVT-VNMLFNKS----------LF-STNKKKIK 51 SIIEKETKEYFESW--GESGE---------KNVFEAL-SELIILTASHCLH-------GKEI--------- 2C9 LNLMEKLNENIK----------ILSSPWIQI-CNNFSPIIDY----FPGTH------------------- 2C19 LNLMEKLNENIR----------IVSTPWIQI-CNNFPTIIDY----FPGTH------------------- 2C18 LNLMEKFNENLR----------ILSSPWIQV-CNNFPALIDY----LPGSH------------------- 2C8 LTLMKRFNENFR----------ILNSPWIQV-CNNFPLLIDC----FPGTH------------------- 2E1 LRLMYLFNENFH----------LLSTPWLQL-YNNFPSFLHY----LPGSH------------------- 2F1 LTIIRLINDNFQ----------IMSSPWGEL-YDIFPSLLDW----VPGPH------------------- 2W1 VSLLGLIDEVMV----------LLGSPGLQL-FNVHPWLGAL----LQLHR------------------- 2B6 LKMLNLFYQTFS----------LISSVFGQL-FELFSGFLKY----FPGAH------------------- 2A6 LSLLRMMLGIFQ----------FTSTSTGQL-YEMFSSVMKH----LPGPQ------------------- 2A7 LSLLSMMLGIFQ----------FTSTSTGQL-YEMFSSVMKH----LPGPQ------------------- 2A13 LSLLRMMLGRFQ----------FTGTSTGQL-YEMFSSVMKH----LPGPQ------------------- 2G1P ---------------------------------------------------------------------- 2G2P LNLLRLINESFI----------EMSTPWAQL-YDMYSGIMQY----LPGRH------------------- 2J2 QQLLKLLDEVTY----------LEASKTCQL-YNVFPWIMKF----LPGPH------------------- 2R1 QHMIELFSENVE----------LAASASVFL-YNAFPWIGIL----PFGKH------------------- 2S1 QAVVRAAGGTLL----------GVSSQGGQT-YEMFSWFLRP----LPGPH------------------- 2T2P LRLLNLFSDNFC----------------IIS-SRWGESLMDW----LPGPH------------------- 2T3P -EVLNLLSDNFR----------------IMS-SKWGESLMDW----LPGPH------------------- 2U1 KKMLGFMSRGLE-----------ICLNSQVL-LVNICPWLYY----LPFGP------------------- 2D6 LRLLDLAQEGLK----------EESGFLREV-LNAVPVLLH-----IPALA------------------- 1A1 LSLVNL-NNNFG----------EVVG-SGNP-ADFIPILRY-----LPNPS------------------- 1A2 LSLVKN-THEFV----------ETAS-SGNP-LDFFPILRY-----LPNPA------------------- 1B1 RELLSH-NEEFG----------RTVG-AGSL-VDVMPWLQY-----FPNPVRTV---------------- 17 NVIQNY-NEGII----------DNLS-KDSL-VDLVPWLKI-----FPNKT------------------- 21 PAYYKCIQEVLK----------TWSH-WSIQIVDVIPFLRF-----FPNPG------------------- 3A4 DPFVENTKKLLR----------FDFLDPFFLSI-IFPFL-------IPILE------------------- 3A5 DPFVESTKKFLK----------FGFLDPLFLSIILFPFL-------TPVFE------------------- 3A7 DPFVENTKKLLR----------FNPLDPFVLSIKVFPFL-------TPILE------------------- 3A43 DPFLKNMKKLLK----------LDFLDPFLLLISLFPFL-------TPVFE------------------- 5A1 DPFVKHCKRFFE----------FCIPRPILVLLLSFPSI-------MVPLA------------------- 4A11 IQAISDLNNLVFSRV-------RNAFHQNDTIYSLTSA-GRW----THRA-------------------- 4A20 --AVFNLSKISNQRM-------NNFLHHNDLVFKFSSQ-GQI----FSKF-------------------- 4B1 -LAVSDLTLLMQQRL-------VSFQYHNDFIYWLTPH-GRR----FLRA-------------------- 4F2 --AILELSALVSKRH-------HEILLHIDFLYYLTPD-GQR----FRRA-------------------- 4F3 --AILELSALVTKRH-------QQILLYIDFLYYLTPD-GQR----FRRA-------------------- 4F8 --AIMELSALVVKRN-------NQFFRYKDFLYFLTPC-GRR----FHRA-------------------- 4F11 --AILELSAFVEKRN-------QQILLHTDFLYYLTPD-GQR----FRRA-------------------- 4F12 --TILELSALVEKRS-------QHILQHMDFLYYLSHD-GRR----FHRA-------------------- 4F22 --AIIELSALSVRRQ-------YRLHHYLDFIYYRSAD-GRR----FRQA-------------------- 4X1 AKAIFELSKIIFHRL-------YSLLYHSDIIFKLSPQ-GYR----FQKL-------------------- 4V2 -RAVYRMSEMIFRRI-------KMPWLWLDLWYLMFKE-GWE----HKKS-------------------- 46 -LGAQKPLSQAVKLM-------LEGITASRNTLAKFLP-GKR----KQLR-------------------- 20 -IRFQKNHGTVWSEI--------GKGFLDGSLDKNMTR-KKQ----YEDA-------------------- 26A1 QLVEA-----------------FEEMTRNLFSLPIDVP-FSG----LYRGMKARNL-------------- 26B1 ----------------------YQQFVDNVFSLPVDLP-FSG----YRRGIQARQI-------------- 26C1 -------------------------------------------------GIRARDQ-------------- 11A1 VNPEAQRFIDAI----------YQMFHTSVPMLNLPPDLFRL----FR---------------------- 11B1 PSSASLNFLHAL----------EVMFKSTVQLMFMPRSLSRW----TS---------------------- 11B2 PSSASLNFLHAL----------EVMFKSTVQLMFMPRSLSRW----IS---------------------- 27A1 IPEDTVTFVRSI----------GLMFQNSLYATFLPKWTRPV---------------------------- 27B1 VPPDTETFIRAV----------GSVFVSTLLTMAMPHWLRHL----V----------------------- 27C1 IPQLTVEYIEAL-------ELMFSMFKTSMYAGAIPRWLRPF----I----------------------- 24 AGDEAVNFIMAI----------KTMMSTFGRMMVTPVELHKS----LN---------------------- 19 DESAIVVKIQGY----------FDAWQALLIKPDIF---FKI---------------------------- 8A1 IEALPRTHESQAQDRVH-----SADVFHTFRQLDRL---LPK----LARGSLSV---------------- 8B1 YTKDKEQDLLQAGELFM-----EFRKFDLLFPRFVY---SLL----WPREWLEV---------------- 7B1 KVIVCDNNKFI-----------SELRDDFLK-FDDK---FAY----LVSNIP------------------ 7A1 RDLTRRDTQKAH----------ILNNLDNFKQFDKV---FPA----LVAGLP------------------ 39 EFHQYFQVYDED----------FEYGSQLPECLLR----------------------------------- 51 RSQLNEKVAQLY----------ADLDGGFSHAAWLLPGW-------LP---------------------- 2C9 ---NKLLKNVAFMKSYILEKVKEHQESMDMNNPQD------FIDCFLM-KMEKEK--HNQPSE----FTIESL 2C19 ---NKLLKNLAFMESDILEKVKEHQESMDINNPQD------FIDCFLI-KMEKEK--QNQQSE----FTIESL 2C18 ---NKIAENFAYIKSYVLERIKEHQESLDMNSARD------FIDCFLI-KMEQEK--HNQQSE----FTVESL 2C8 ---NKVLKNVALTRSYIREKVKEHQASLDVNNPRD------FIDCFLI-KMEQEK--DNQKSE----FNIENL 2E1 ---RKVIKNVAEVKEYVSERVKEHHQSLDPNCPRD------LTDCLLV-EMEKEK--HSAERL----YTMDGI 2F1 ---QRIFQNFKCLRDLIAHSVHDHQASLDPRSPRD------FIQCFLT-KMAEEK--EDPLSH----FHMDTL 2W1 ---PVLRKIEEVRAILRTLLEARRPHVCPGDPVCS------YVDALIQ-QGQGDD--PEGL------FAEANA 2B6 ---RQVYKNLQEINAYIGHSVEKHRETLDPSAPKD------LIDTYLL-HMEKEK--SNAHSE----FSHQNL 2A6 ---QQAFQLLQGLENFIAKKVEHNQRTLDPNSPRD------FIDSFLI-RMQEEE--KNPNTE----FYLKNL 2A7 ---QQAFKLLQGLENFIAKKVEHNQRTLDPNSPQD------FIDSFLI-HMQEEE--KNPNTE----FYLKNL 2A13 ---QQAFKELQGLEDFIAKKVEHNQRTLDPNSPRD------FIDSFLI-RMQEEE--KNPNTE----FYLKNL 2G1P ------------------------------------------------------------------------- 2G2P ---NLIYYLVEELKDFIASRVKINEASFDPQNPRD------FIDCFLI-KMHQDK--NNPRTE----FNLKNL 2J2 ---QTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD------FIDAYLK-EMSKHT--GNPTSS----FHEENL 2R1 ---QQLFRNAAVVYDFLSRLIEKASVNRKPQLPQH------FVDAYLD-EMDQGK--NDPSST----FSKENL 2S1 ---KQLLHHVSTLAAFTVRQVQQHQGNLDASGPARD-----LVDAFLL-KMAQEE--QNPGTE----FTNKNM 2T2P ---HRIFRNFSELRV-ISEQIQRHWQMRQPAEPRD------FIDCLTR-WVRHGQ--QDPESH----FQE*TS 2T3P ---HQIFQNFSELQVFISEQIQQHWHMRQPAEPRD------FIDCLAR-WVRHGQ--QDPESH----FQEETL 2U1 --FKELRQIEKDITSFLKKIIKDHQESLDRENPQD------FIDMYLL-HMEEER--KNNSNSS---FDEEYL 2D6 ---GKVLRFQKAFLTQLDELLTEHRMTWDPQPPRD------LTEAFLA-EMEKAK--GNPESS----FNDENL 1A1 --LNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRD------ITDSLIE-HCQEKQLDENANVQ----LSDEKI 1A2 --LQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRD------ITGALFK-HSKKGP-RASGNL-----IPQEKI 1B1 --FREFEQLNRNFSNFILDKFLRHCESLRPGAPRD------MMDAFIL-SAEKKAAGDSHGGGAR--LDLENV 17 --LEKLKSHVKIRNDLLNKILENYKEKFRSDSITN------MLDTLMQ-AKMNSDNGNAGPDQDSELLSDNHI 21 --LRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRD------MMDYMLQ-GVAQPSMEE-GSGQ----LLEGHV 3A4 --VLNICVFPREVTNFLRKSVKRMKESRLEDTQKH------RVD-FLQLMIDSQN-SKETESHKA--LSDLEL 3A5 --ALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKH------RLD-FLQLMIDSQN-SKETESHKA--LSDLEL 3A7 --ALNITVFPRKVISFLTKSVKQIKEGRLKETQKH------RVD-FLQLMIDSQN-SKDSETHKA--LSDLEL 3A43 --ALNIGLFPKDVTHFLKNSIERMKESRLKDKQKH------RVD-FFQQMIDSQN-SKETKSHKA--LSDLEL 5A1 --RILPNKNRDELNGFFNKLIRNVIALRDQQAAEE------RRD-FLQMVLDARH-SASPMGVQDFDLTVDEI 4A11 --CQLAHQHTDQ--VIQLRKAQLQKEGELEKIKRKR-----HLD-FLDILLL--AKMENGSI-----LSDKDL 4A20 --NQELHQFTHLEKVIQDRKESLKDKLKQDTTQKR------RWD-FLDILLS--AKVENTKD-----FSEADL 4B1 --CQVAHDHTDQ--VIRERKAALQDEKVRKKIQNRR-----HLD-FLDILLG--ARDEDDIK-----LSDADL 4F2 --CRLVHDFTDA--VIQERRRTLPSQGVDDFLQAKAKSK--TLD-FIDVLLL--SKDEDGKK-----LSDEDI 4F3 --CRLVHDFTDD--VIQERRRTLPSQGVDDFLQAKAKSK--TLD-FIDVLLL--SKDEDGKK-----LSDEDI 4F8 --CRLVHDFTDA--VIQERRRTLTSQGVDDFLQAKAKSK--TLD-FIDVLLL--SEDKNGKE-----LSDEDI 4F11 --CHLVHDFTDA--VIQERRRTLPTQGIDDFLKNKAKSK--TLD-FIDVLLL--SKDEDGKE-----LSDEDI 4F12 --CRLVHDFTDA--VIRERRRTLPTQGIDDFFKDKAKSK--TLD-FIDVLLL--SKDEDGKA-----LSDEDI 4F22 --CDMVHHFTTE--VIQERRRALRQQGAEAWLKAK-QGK--TLD-FIDVLLL--ARDEDGKE-----LSDEDI 4X1 --SRVLNQYTDT--IIQERKKSLQAGVKQDNTPKRK-----YQD-FLDIVLS--AKDESGSS-----FSDIDV 4V2 --LQILHTFTNS--VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLS--VTDDEGNR-----LSHEDI 46 --EVRESIRFLRQVGRDWVQRRREALKRGEEV-------------PADILTQ--ILKAEEGA-----QDDEGL 20 --LMQLESVLRN--IIKERKGRNFSQHI-----------------FIDSLVQ--GN-----------LNDQQI 26A1 --IHARIEQNIRAKICGLRASEAGQG------------CKD----ALQLLIE--HSWERGER-----LDMQAL 26B1 --LQKGLEKAIREKLQCTQGKDYL----------------D----ALDLLIE--SSKEHGKE-----MTMQEL 26C1 --LHRHLEGAISEKLHEDKAAEPG----------------D----ALDLIIH--SARELGHE-----PSMQEL 11A1 --TKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSV-HHD---YRGMLYRL--LGDSK--------MSFEDI 11B1 --PKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-SRPQQ-Y----TSIVAEL--LLNAE--------LSPDAI 11B2 --PKVWKEHFEAWDCIFQYGDNCIQKIYQELAF-NRPQH-Y----TGIVAEL--LLKAE--------LSLEAI 27A1 --LPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPD----GIQVSGY---LHFLLASGQ---LSPREA 27B1 --PGPWGRLCRDWDQMFAFAQRHVERREAEAAMRNGGQPEK----DLESGAH--LTHFLFREE----LPAQSI 27C1 --PKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRG-------RRVSGGL--LTYLFLSQA----LTLQEI 24 --TKVWQGHTLAWDTIFKSVKACIDNRLE---------KYS----QQPSADF--LCDIYHQNR----LSKKEL 19 --SWLYKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECMD---FATELILAEKRGD---------LTRENV 8A1 ---GDKDHMCSVKSRLWKLLSPARLARRAHRSKW----LESY---LLHLEEMG--------------VSEEMQ 8B1 ---GRLQHLFHKMLSVSHSQEKEGISNWLGNMLQ-----------FLREQG----------------VPSAMQ 7B1 --IELLGNVKSIREKIIKCFSSEKLAKMQGWSEV----FQSR---QDVLEKYYV-------------HEDLEI 7A1 --IHMFRTAHNAREKLAESLRHENLQKRESISEL----ISLR---MFLNDTLST-------------FDDLEK 39 --NWSKSKKWFLELFEKNIPDIKACKSAKDNSMT-----------LLQATL--DIVETE--------TSKENS 51 --LPSFRRRDRAHREIKDIFYKAIQKRRQSQ-EK----IDD----ILQTLL--DATYKDGRP-----LTDDEV 2C9 ENTAVDL---FGAGTETTSTTLRYALLLLLKH-PEVTAKVQEEIERVIG----RNR-------SPCMQDRSHM 2C19 VITAADL---LGAGTESTSTTLRYALLLLLKH-PEVTAKVQEEIERVIG----RNR-------SPCMQDRGHM 2C18 IATVTDM---FGAGTETTSTTLRYGLLLLLKY-PEVTAKVQEEIECVVG----RNR-------SPCMQDRSHM 2C8 VGTVADL---FVAGTETTSTTLRYGLLLLLKH-PEVTAKVQEEIDHVIG----RHR-------SPCMQDRSHM 2E1 TVTVADL---FFAGTETTSTTLRYGLLILMKY-PEIEEKLHEEIDRVIG----PSR-------IPAIKDRQEM 2F1 LMTTHNL---LFGGTKTVSTTLHHAFLALMKY-PKVQARVQEEIDLVVG----RAR-------LPALKDRAAM 2W1 VACTLDM---VMAGTETTSATLQWAALLMGRH-PDVQGRVQEELDRVLG----PGR-------TPRLEDQQAL 2B6 NLNTLSL---FFAGTETTSTTLRYGFLLMLKY-PHVAERVYREIEQVIG----PHR-------PPELHDRAKM 2A6 VMTTLNL---FIGGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRAKM 2A7 MMSTLNL---FIAGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRTKM 2A13 VMTTLNL---FFAGTETVSTTLRYGFLLLMKH-PEVEAKVHEEIDRVIG----KNR-------QPKFEDRAKM 2G1P -------------------------------------AKIHEEINQVIG----PHR-------LPRVDDRVKM 2G2P VLTTLNL---FFAGTETVSSTLRYGFLLLMKH-PEVEAKIHEEINQVIG----PHR-------LPRVDDRVKM 2J2 ICSTLDL---FFAGTETTSTTLRWALLYMALY-PEIQEKVQVEIDRVIG----QGQ-------QPSTAARESM 2R1 IFSVGEL---IIAGTETTTNVLRWAILFMALY-PNIQGQVQKEIDLIMG----PNG-------KPSWDDKCKM 2S1 LMTVIYL---LFAGTMTVSTTVGYTLLLLMKY-PHVQKWVREELNRELG----AGQ-------APSLGDRTRL 2T2P VMT-THF---FFGVTETTSTTLCYGLLILLKY-LEVAAKVQ-ELDPVVG----WRP-------APSLDYRVCL 2T3P VMTMQLFFFFFFGGTETTSTTLC--------------AKGQ-ELDPVVG----QRP-------VPSPDDHVQW 2U1 FYIIGDL---FIAGTDTTTNSLLWCLLYMSLN-PDVQKVHE-EIERVIG----ANR-------APSLTDKAQM 2D6 RIVVADL---FSAGMVTTSTTLAWGLLLMILH-PDVQRRVQQEIDDVIG----QVR-------RPEMGDQAHM 1A1 INIVLDL---FGAGFDTVTTAISWSLMYLVMN-PRVQRKIQEELDTVIG----RSR-------RPRLSDRSHL 1A2 VNLVNDI---FGAGFDTVTTAISWSLMYLVTK-PEIQRKIQKELDTVIG----RER-------RPRLSDRPQL 1B1 PATITDI---FGASQDTLSTALQWLLLLFTRY-PDVQTRVQAELDQVVG----RDR-------LPCMGDQPNL 17 LTTIGDI---FGAGVETTTSVVKWTLAFLLHN-PQVKKKLYEEIDQNVG----FSR-------TPTISDRNRL 21 HMAAVDL---LIGGTETTANTLSWAVVFLLHH-PEIQQRLQEELDHELGPGASSSR-------VP-YKDRARL 3A4 VAQSIIF---IFAGYETTSSVLSFIMYELATH-PDVQQKLQEEIDAVLP----NKA-------PPTYDTVLQM 3A5 AAQSIIF---IFAGYETTSSVLSFTLYELATH-PDVQQKLQKEIDAVLP----NKA-------PPTYDAVVQM 3A7 MAQSIIF---IFAGYETTSSVLSFIIYELATH-PDVQQKVQKEIDTVLP----NKA-------PPTYDTVLQL 3A43 VAQSIII---IFAAYDTTSTTLPFIMYELATH-PDVQQKLQEEIDAVLP----NKA-------PVTYDALVQM 5A1 VGQAFIF---LIAGYEIITNTLSFATYLLATN-PDCQEKLLREVDVFKEK---HMA-------PEFCSLEEGL 4A11 RAEVDTF---MFEGHDTTASGISWILYALATH-PKHQERCREEIHSLLG----DGA-------SITWNHLDQM 4A20 QAEVKTF---MFAGHDTTSSAISWILYCLAKY-PEHQQRCRDEIRELLG----DGS-------SITWEHLSQM 4B1 RAEVDTF---MFEGHDTTTSGISWFLYCMALY-PEHQHRCREEVREILG----DQD-------FFQWDDLGKM 4F2 RAEADTF---MFEGHDTTASVSPGSCTTLQST-QNTRSVCRQEVQELLK----DRE-----PKEIEWDDLAHL 4F3 RAEADTF---MFEGHDTTASGLSWVLYHLAKH-PEYQERCRQEVQELLK----DRE-----PKEIEWDDLAQL 4F8 RAEADTF---MFGGHDTTASGLSWVLYNLARH-PEYQERCRQEVQELLK----DRE-----PKEIEWDDLAQL 4F11 RAEADTF---MFEGHDTTASGLSWVLYHLAKH-PEYQEQCRQEVQELLK----DRE-----PIEIEWDDLAQL 4F12 RAEADTF---MFGGHDTTASGLSWVLYNLARH-PEYQERCRQEVQELLK----DRD-----PKEIEWDDLAQL 4F22 RAEADTF---MFEGHDTTSSGISWMLFNLAKY-PEYQEKCREEIQEVMK----GRE-----LEELEWDDLTQL 4X1 HSEVSTF---LLAGHDTLAASISWILYCLALN-PEHQERCREEVRGILG----DGS-------SITWDQLGEM 4V2 REEVDTF---MFEGHDTTAAAINWSLYLLGSN-PEVQKKVDHELDDVKS----DRP--------ATVEDLKKL 46 LDNFVTF---FIAGHETSANHLAFTVMELSRQ-PEIVARLQAEVDEVIG----SKR-------YLDFEDLGRL 20 LEDSMIF---SLASCIITAKLCTWAICFLTTS-EEVQKKLYEEINQVFG----NGP--------VTPEKIEQL 26A1 KQSSTEL---LFGGHETTASAATSLITYLGLY-PHVLQKVREELKSKGLLCKSNQDN------KLDMEILEQL 26B1 KDGTLEL---IFAAYATTASASTSLIMQLLKH-PTVLEKLRDELRAHGILHSGG----CPCEGTLRLDTLSGL 26C1 KESAVEL---LFAAFFTTASASTSLVLLLLQH-PAAIAKIREELVAQGLGRACGCAPGCGCEPDLSLAALGRL 11A1 KANVTEM---LAGGVDTTSMTLQWHLYEMARN-LKVQDMLRAEVLAARH-----QAQG-----DMATM-LQLV 11B1 KANSMEL---TAGSVDTTVFPLLMTLFELARN-PNVQQALRQESLAAAA-----SISE-----HPQKA-TTEL 11B2 KANSMEL---TAGSVDTTAFPLLMTLFELARN-PDVQQILRQESLAAAA-----SISE-----HPQKA-TTEL 27A1 MGSLPEL---LMAGVDTTSNTLTWALYHLSKN-PEIQEALHEEVVGVVP-----AGQV------PQHKDFAHM 27B1 LGNVTEL---LLAGVDTVSNTLSWALYELSRH-PEVQTALHSEITAALS-----PGSS----AYPSATVLSQL 27C1 YANVTEM---LLAGVDTTSFTLSWTVYLLARH-PEVQQTVYREIVKNLG-----ERHV------PTAADVPKV 24 YAAVTEL---QLAAVETTANSLMWILYNLSRN-PQVQQKLLKEIQSVLP-----ENQR-----PREED-LRNM 19 NQCILEM---LIAAPDTMSVSLFFMLFLIAKH-PNVEEAIIKEIQTVIG-----ER-------DIKIDDIQKL 8A1 ARALVLQ---LWATQGNMGPAAFWLLLFLLKN-PEALAAVRGELESILWQAEQPVSQTT----TLPQKVLDST 8B1 DKFNFMM---LWASQGNTGPTSFWALLYLLKH-PEAIRAVREEATQVLGEARLETKQSFA---FKLGA-LQHT 7B1 GAHHLGF---LWASVANTIPTMFWAMYYLLRH-PEAMAAVRDEIDRLLQSTGQKKGSGFPI--HLTREQLDSL 7A1 AKTHLVV---LWASQANTIPATFWSLFQMIRN-PEAMKAATEEVKRTLENAGQKVSLEGNPI-CLSQAELNDL 39 PNYGLLL---LWASLSNAVPVAFWTLAYVLSH-PDIHKAIMEGISSVFGKAGKDKI-------KVSEDDLENL 51 AGMLIGL---LLAGQHTSSTTSAWMGFFLARD-KTLQKKCYLEQKTVCGE---NLP-------PLTYDQLKDL 2C9 PYTDAVVHEVQRYIDLLPTSL--PHAVTCDIKFRN--------YLIPKGTTILISLTSVLHDNKE-FPNP 2C19 PYTDAVVHEVQRYIDLIPTSL--PHAVTCDVKFRN--------YLIPKGTTILTSLTSVLHDNKE-FPNP 2C18 PYTDAVVHEIQRYIDLLPTNL--PHAVTCDVKFKN--------YLIPKGTTIITSLTSVLHNDKE-FPNP 2C8 PYTDAVVHEIQRYSDLVPTGV--PHAVTTDTKFRN--------YLIPKGTTIMALLTSVLHDDKE-FPNP 2E1 PYMHAVVHEIQRFITLVPSNL--PHEATRDTIFRG--------YIIPKGTVIVPTLDSVLYDNQE-FPDP 2F1 PYTDAVIHEVQRFADIIPMNL--PHRVTRDTAFRG--------FLIPKGTDVITLLNTVHYDPSQ-FLTP 2W1 PYTSAVLHEVQRFITLLPHV---PRCTAADTQLGG--------FLLPKGTPVIPLLTSVLLDETQ-WQTP 2B6 PYTEAVIYEIQRFSDLLPMGV--PHIVTQHTSFRG--------YIIPKDTEVFLILSTALHDPHY-FEKP 2A6 PYMEAVIHEIQRFGDVIPMSL--ARRVKKDTKFRD--------FFLPKGTEVYPMLGSVLRDPSF-FSNP 2A7 PYMEAVIHEIQRFGDVIPMSL--ARRVKKDTKFRD--------FFLPKGTEVFPMLGSVLRDPSF-FSNP 2A13 PYTEAVIHEIQRFGDMLPMGL--AHRVNKDTKFRD--------FFLPKGTEVFPMLGSELRDPRF-FSNP 2G1P PYTDVVIHEIQRLVDIVPMGV--PHNIIQDTQFRG--------YLLPKGTDVFPLLGSVLKDPKY-FRYP 2G2P PYTDAVIHEIQRLVDIVPMGV--PHNLIRDTQFRG--------YLLPKGTDVFPLLGSVLKDPKY-FRYP 2J2 PYTNAVIHEVQRMGNIIPQNV--PREVTVDTTLAG--------YHLPKGTMILTNLTALHRDPTE-WATP 2R1 PYTEAVLHEVLRFCNIVPLGI--FHATSEDAVVRG--------YSIPKGTTVITNLYSVHFDEKY-WRDP 2S1 PYTDAVLHEAQRLLALVPMGI--PRTLMRTTRFRG--------YTLPQGTEVFPLLGSILHEPNI-FKHP 2T2P PYANAVLLEIQCFISVVPLGL--PRTLTLDTHLHS--------HCLPKGTFVIPLLVTAHRDPTQ-FKDP 2T3P PYTNAVLLEIQRFISVV------PRTLTLDTHLHS--------HCLAKG--------------------- 2U1 PYTEATIMEVQRLTVVVPLAI--PHMTSENT-LQG--------YTIPKGTLILPNLWSVHRDPAI-WEKP 2D6 PYTTAVIHEVQRFGDIVPLGM--THMTSRDIEVQG--------FRIPKGTTLITNLSSVLKDEAV-WEKP 1A1 PYMEAFILETFRHSSFVPFTI--PHSTTRDTSLKG--------FYIPKGRCVFVNQWQINHDQKL-WVNP 1A2 PYLEAFILETFRHSSFLPFTI--PHSTTRDTTLNG--------FYIPKKCCVFVNQWQVNHDPEL-WEDP 1B1 PYVLAFLYEAMRFSSFVPVTI--PHATTANTSVLG--------YHIPKDTVVFVNQWSVNHDPVK-WPNP 17 LLLEATIREVLRLRPVAPMLI--PHKANVDSSIGE--------FAVDKGTEVIINLWALHHNEKE-WHQP 21 PLLNATIAEVLRLRPVVPLAL--PHRTTRPSSISG--------YDIPEGTVIIPNLQGAHLDETV-WERP 3A4 EYLDMVVNETLRLFPIAMRLE--RVCK-KDVEING--------MFIPKGWVVMIPSYALHRDPKY-WTEP 3A5 EYLDMVVNETLRLFPVAIRLE--RTCK-KDVEING--------VFIPKGSMVVIPTYALHHDPKY-WTEP 3A7 EYLDMVVNETLRLFPVAMRLE--RVCK-KDVEING--------MFIPKGVVVMIPSYVLHHDPKY-WTEP 3A43 EYLDMVVNETLRLFPVVSRVT--RVCK-KDIEING--------VFIPKGLAVMVPIYALHHDPKY-WTEP 5A1 PYLDMVIAETLRMYPPAFRFT--REAA-QDCEVLG--------QRIPAGAVLEMAVGALHHDPEH-WPSP 4A11 PYTTMCIKEALRLYPPVPGIG--RELSTPVTFPDG--------RSLPKGIMVLLSIYGLHHNPKV-WPNP 4A20 PYTTMCIKECLRLYAPVVNIS--RLLDKPITFPDG--------RSLPAGITVFINIWALHHNPYF-WEDP 4B1 TYLTMCIKESFRLYPPVPQVY--RQLSKPVTFVDG--------RSLPAGSLISMHIYALHRNSAV-WPDP 4F2 PFLTMCMKESLRCIPPVPVIS--RHVTQDIVLPDG--------RVIPKGIICLISVFGTHHNPAV-WPDP 4F3 PFLTMCIKESLRLHPPVPAVS--RCCTQDIVLPDG--------RVIPKGIICLISVFGTHHNPAV-WPDP 4F8 PFLTMCLKESLRLHPPIPTFA--RGCTQDVVLPDS--------RVIPKGNVCNINIFAIHHNPSV-WPDP 4F11 PFLTMCIKESLRLHPPVPVIS--RCCTQDFVLPDG--------RVIPKGIVCLINIIGIHYNPTV-WPDP 4F12 PFLTMCVKESLRLHPPAPFIS--RCCTQDIVLPDG--------RVIPKGITCLIDIIGVHHNPTV-WPDP 4F22 PFTTMCIKESLRQYPPVTLVS--RQCTEDIKLPDG--------RIIPKGIICLVSIYGTHHNPTV-WPDS 4X1 SYTTMCIKETCRLIPAVPSIS--RDLSKPLTFPDG--------CTLPAGITVVLSIWGLHHNPAV-WKNP 4V2 RYLECVIKETLRLFPSVPLFA--RSVSEDYFLTAG--------YRVLKGTEAVIIPYALHRDPRY-FPNP 46 QYLSQVLKESLRLYPPAWGTF--RLLEEET-LIDG--------VRVPGNTPLLFSTYVMGRMDTY-FEDP 20 RYCQHVLCETVRTAKLTPVSA--QLQD-IEGKIDR--------FIIPRETLVLYALGVVLQDPNT-WPSP 26A1 KYIGCVIKETLRLNPPVPGGF--RVAL-KTFELNG--------YQIPKGWNVIYSICDTHDVAEI-FTNK 26B1 RYLDCVIKEVMRLFTPISGGY--RTVL-QTFELDG--------FQIPKGWSVMYSIRDTHDTAPV-FKDV 26C1 RYVDCVVKEVLRLLPPVSGGY--RTAL-RTFELNG--------YQIPKGWSVMYSIRDTHETAAV-YRSP 11A1 PLLKASIKETLRLHPISVTLQ--RYLV-NDLVLRD--------YMIPAKTLVQVAIYALGREPTF-FFDP 11B1 PLLRAALKETLRLYPVGLFLE--RVAS-SDLVLQN--------YHIPAGTLVRVFLYSLGRNPAL-FPRP 11B2 PLLRAALKETLRLYPVGLFLE--RVVS-SDLVLQN--------YHIPAGTLVQVFLYSLGRNAAL-FPRP 27A1 PLLKAVLKETLRLYPVVPTNS--RIIE-KEIEVDG--------FLFPKNTQFVFCHYVVSRDPTA-FSEP 27B1 PLLKAVVKEVLRLYPVVPGNS--RVPD-KDIHVGD--------YIIPKNTLVTLCHYATSRDPAQ-FPEP 27C1 PLVRALLKETLRLFPVLPGNG--RVTQ-EDLVIGG--------YLIPKGTQLALCHYATSYQDEN-FPRA 24 PYLKACLKESMRLTPGVPFTT--RTLD-KATVLGE--------YALPKGTVLMLNTQVLGSSEDN-FEDS 19 KVMENFIYESMRYQPVVDLVM--RKAL-EDDVIDG--------YPVKKGTNIILNIGRMHR-LEF-FPKP 8A1 PVLDSVLSESLRLTAAPFIT---REVV-VDLAMPMADGREF--NLRRGDRLLLFPFLSPQRDPEI-YTDP 8B1 PVLDSVVEETLRLRAAPTLL---RLVH-EDYTLKMSSGQEY--LFRHGDILALFPYLSVHMDPDI-HPEP 7B1 ICLESSIFEALRLSSYSTTI---RFVE-EDLTLSSETGDY---CVRKGDLVAIFPP-VLHGDPEI-FEAP 7A1 PVLNSIIKESLRLSSASLNI---RTAK-EDFTLHLEDGS----YNIRKDSIIALYPQLMHLDPEI-YPDP 39 LLIKWCVLETIRLKAPGVIT---RKVV-KPVEILN--------YIIPSGDLLMLSPFWLHRNPKY-FPEP 51 NLLDRCIKETLRLRPPIMIMM--RMAR-TPQTVAG--------YTIPPGHQVCVSPTVNQRLKDS-WVER 2C9 -EMFDPHHFLDEGG--------------------NFKKSKYFMPFSAGKRICVGEALAGMELFLF-LTSI 2C19 -EMFDPRHFLDEGD--------------------NFKKSNYFMPFSAGKRICVGEGLARMELFLF-LTFI 2C18 -EMFDPGHFLDKSG--------------------NFKKSDYFMPFSAGKRMCMGEGLARMELFLF-LTTI 2C8 -NIFDPGHFLDKNG--------------------NFKKSDYFMPFSAGKRICAGEGLARMELFLF-LTTI 2E1 -EKFKPEHFLNENG--------------------KFKYSDYFKPFSTGKRVCAGEGLARMELFLL-LCAI 2F1 -QEFNPEHFLDANQ--------------------SFKKSPAFMPFSAGRRLCLGELLARMELFLY-LTAI 2W1 -GQFNPGHFLDANG--------------------HFVKREAFLPFSAGRRVCVGERLARTELFLL-FAGL 2B6 -DAFNPDHFLDANG--------------------ALKKTEAFIPFSLGKRICLGEGIARAELFLF-FTTI 2A6 -QDFNPQHFLNEKG--------------------QFKKSDAFVPFSIGKRNCFGEGLARMELFLF-FTTV 2A7 -QDFNPQHFLDDKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-FTTV 2A13 -QDCSPQHFLDEKG--------------------QFKKSDAFVPFSIGKRYCFGEGLARMELFLF-FTTI 2G1P -DAFYPQHFLDEQG--------------------RFKKNEAFVPFSSGKRICLGEAMARMELFLY-FTST 2G2P -DAFYPQHFLDEQG--------------------RFKKNEAFVPFSSGKRICLGEAMDRMELFLY-FTST 2J2 -DTFNPDHFL-ENG--------------------QFKKREAFMPFSIGKRACLGEQLARTELFIF-FTSL 2R1 -EVFHPERFLDSSG--------------------YFAKKEALVPFSLGRRHCLGEHLARMEMFLF-FTAL 2S1 -EEFNPDRFLDADG--------------------RFRKHEAFLPFSLGKRVCLGEGLAKAEVFLF-FTTI 2T2P -DCFNPTNFLD-KG--------------------KFQGNDAFMPFAPAKQMCLGTGLAHSGIFLF-LTAT 2T3P ---------------------------------------------------------------------- 2U1 -EDFYPNRFLDDQG--------------------QLIKKETFIPFGIGKRVCMGEQLAKMELFLM-FVSL 2D6 -FRFHPEHFLDAQG--------------------HFVKPEAFLPFSAGRRACLGEPLARMELFLF-FTSL 1A1 -SEFLPERFLTPDG------------------AIDKVLSEKVIIFGMGKRKCIGETIARWEVFLF-LAIL 1A2 -SEFRPERFLTADG-----------------TAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF-LAIL 1B1 -ENFDPARFLDKDG------------------LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF-ISIL 17 -DQFMPERFLNPAG------------------TQLISPSVSYLPFGAGPRSCIGEILARQELFLI-MAWL 21 -HEFWPDRFLEPGK------------------------NSRALAFGCGARVCLGEPLARLELFVV-LTRL 3A4 -EKFLPERFSKKNK--------------------DNIDPYTYTPFGSGPRNCIGMRFALMNMKLA-LIRV 3A5 -EEFRPERFSKKK---------------------DSIDPYIYTPFGTGPRNCIGMRFALMNMKLA-LIRV 3A7 -EKFLPERFSKKNK--------------------DNIDPYIYTPFGSGPRNCIGMRFALVNMKLA-LVRV 3A43 -EKFCPERFSKKNK--------------------DSIDLYRYIPFGAGPRNCIGMRFALTNIKLA-VIRA 5A1 -ETFNPERFTAEAR--------------------QQHRPFTYLPFGAGPRSCLGVRLGLLEVKLT-LLHV 4A11 -EVFDPFRFAPG----------------------SAQHSHAFLPFSGGSRNCIGKQFAMNELKVA-TALT 4A20 -QVFNPLRFSRENS--------------------EKIHPYAFIPFSAGPRNCIGQHFAIIECKVA-VALT 4B1 -EVFDSLRFSTENA--------------------SKRHPFAFMPFSAGPRNCIGQQFAMSEMKVV-TAMC 4F2 -EVYDPFRFDPENI--------------------KERSPLAFIPFSAGPRNCIGQTFAMAEMKVV-LALT 4F3 -EVYDPFRFDPKNI--------------------KERSPLAFIPFSAGPRNCIGQAFAMAEMKVV-LGLT 4F8 -EVYDPFRFDPENA--------------------QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVV-LALT 4F11 -EVYDPFRFNQENI--------------------KERSPLAFIPFSAGPRNCIGQAFAMAEMKVV-LALT 4F12 -EVYDPFRFDPENS--------------------KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVV-LALM 4F22 -KVYNPYRFDPDNP--------------------QQRSPLAYVPFSAGPRNCIGQSFAMAELRVV-VALT 4X1 -KVFDPLRFSQENS--------------------DQRHPYAYLPFSAGSRNCIGQEFAMIELKVT-IALI 4V2 -EEFQPERFFPENA--------------------QGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI-LSCI 46 -LTFNPDRFGPG----------------------APKPRFTYFPFSLGHRSCIGQQFAQMEVKVV-MAKL 20 -HKFDPDRFDDE----------------------LVMKTFSSLGFS-GTQECPELRFAYMVTTVL-LSVL 26A1 -EEFNPDRFIAPHPED--------------------ASRFSFIPFGGGLRSCVGKEFAKILLKIF-TVEL 26B1 -NVFDPDRFSQARSED-------------------KDGRFHYLPFGGGVRTCLGKHLAKLFLKVL-AVEL 26C1 -PEGFDPERFGAAREDSRG----------------ASSRFHYIPFGGGARSCLGQELAQAVLQLL-AVEL 11A1 -ENFDPTRWLSKDK---------------------NITYFRNLGFGWGVRQCLGRRIAELEMTIF-LINM 11B1 -ERYNPQRWLDIKG---------------------SGRNFYHVPFGFGMRQCLGRRLAEVEMLLL-LHHV 11B2 -ERYNPQRWLDIRG---------------------SGRNFHHVPFGFGMRQCLGRRLAEAEMLLL-LHHV 27A1 -ESFQPHRWLRNSQPATPR----------------IQHPFGSVPFGYGVRACLGRRIAELEMQLL-LARL 27B1 -NSFRPARWLGEGP---------------------TPHPFASLPFGFGKRSCMGRRLAELELQMA-LAQI 27C1 -KEFRPERWLRKGDLD-------------------RVDNFGSIPFGHGVRSCIGRRIAELEIHLV-VIQL 24 -SQFRPERWLQEKE---------------------KINPFAHLPFGVGKRMCIGRRLAELQLHLA-LCWI 19 -NEFTLENFAK------------------------NVPYRYFQPFGFGPRGCAGKYIAMVMMKAI-LVTL 8A1 -EVFKYNRFLNPDGSEKKDFYKDG-----------KRLKNYNMPWGAGHNHCLGRSYAVNSIKQF-VFLV 8B1 -TVFKYDRFLNPNGSRKVDFFKTG-----------KKIHHYTMPWGSGVSICPGRFFALSEVKLF-ILLM 7B1 -EEFRYDRFIED-GKKKTTFFKRG-----------KKLKCYLMPFGTGTSKCPGRFFALMEIKQL-LVIL 7A1 -LTFKYDRYLDENGKTKTTFYCNG-----------LKLKYYYMPFGSGATICPGRLFAIHEIKQF-LILM 39 -ELFKPERWEKGKFRRKH-----------------SFLGTASWAFGAGSSQCPGKVFALLEVQMC-IILI 51 -LDFNPDRYLQDNPA--------------------SGEKFAYVPFGAGRHRCIGENFAYVQIKTI-WSTM 2C9 LQNF-NLKSLVDPKNLDTTPVVNGFASVPPFYQLCFI-PV*------------------- 2C19 LQNF-NLKSLIDPKDLDTTFVVNGFASVPPFYQLCFI-PV*------------------- 2C18 LQNF-NLKSQVDPKDIDITPLPMHLVGVPPLYQLCFI-PV*------------------- 2C8 LQNF-NLKSVDDLKNLNTTAVTKGIVSLPPSYQICFI-PV*------------------- 2E1 LQHF-NLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVI-PRS*------------------ 2F1 LQSF-SLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLR-PR*------------------- 2W1 LQRYRLLPPPGSPASLDTTP-ARAFTMRPRPRALCAV-PRP*------------------ 2B6 LQNF-SMASPVAPEDIDLTPQECGVGKIPPTYQIRFL-PR*------------------- 2A6 MQNF-RLKSSQSPKDIDVSPKHVGFATIPRNYTMSFL-PR*------------------- 2A7 MQNF-RLKSSQSPKDIDVSSKHVGFATIPRNYTMSFL-PR*------------------- 2A13 MQNF-RFKSPQSPKDIDVSPKHVGFATIPRNYTMSFL-PR*------------------- 2G1P LQNF-SLCSLVPLVDIDITPKLSGFGNITPTYELCLV-AR*------------------- 2G2P LQNF-SLHSLVPPVDIDITPKLSGFGNIPPTYELCLV-AR*------------------- 2J2 MQKF-TFRPPNNEKLSLKFRM--GITISPVSHRLCAV-PQV*------------------ 2R1 LQRF-HLHFPHELVPDLKPRL--GMTLQPQPYLICAE-RR*------------------- 2S1 LQAF-SLESPCPPDTLSLKPTVSGLFNIPPAFQLQVR-PTDLHSTTQTR*---------- 2T2P LQRF-CLLPVVRPGTINLTQCT-GLGSVPPDFQLQPV-AC*------------------- 2T3P ----------------------------------------*------------------- 2U1 MQSF-AFALPEDSKKPLLTGRF-GLTLAPHPFNITIS-RR*------------------- 2D6 LQHF-SFSVPTG-QPRPSHHGVFAFLVSPSPYELCAV-PR*------------------- 1A1 LQRV-EFSVPLG-VKVDMTPIYGLTMKHACCEHFQMQ-LRS*------------------ 1A2 LQQL-EFSVPPG-VKVDLTPIYGLTMKHARCEHVQAR-LRFSIN*--------------- 1B1 AHQC-DFRANPN-EPAKMNFSYGLTIKPKSFKVNVTL-RESMELLDSAVQNLQAKETCQ* 17 LQRF-DLEVPDD-GQLPSLEGIPKVVFLIDSFKVKIK-VRQAWREAQAEGST*------- 21 LQAF-TLLPSGD-ALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ*-------- 3A4 LQNF-SFKPCKE-TQIPLKLSLGGLLQ-PEKPVVLKVESRDGTVSGA*------------ 3A5 LQNF-SFKPCKE-TQIPLKLDTQGLLQ-PEKPIVLKVDSRDGTLSGE*------------ 3A7 LQNF-SFKPCKE-TQIPLKLRFGGLLL-TEKPIVLKAESRDETVSGA*------------ 3A43 LQNF-SFKPCKE-TQIPLKLDNLPILQ-PEKPIVLKVHLRDGITSGP*------------ 5A1 LHKF-RFQACPE-TQVPLQLESKSALG-PKNGVYIKIVSR*------------------- 4A11 LLRF-ELLP--DPTRIPI-PIARLVLK-SKNGIHLRLRRLPNPCEDKDQL*--------- 4A20 LLRF-KLAP--DHSRPPQ-PVRQVVLK-SKNGIHVFAKKV*------------------- 4B1 LLRF-EFSL--DPSRLPI-KMPQLVLR-SKNGFHLHLKPLGPGSGK*------------- 4F2 LLAF-RVLP--DHTEPRRSRSWSCAQR-ADFGCGWSP*---------------------- 4F3 LLAF-RVLP--DHTEPRR-K-PELVLR-AEGGLWLRVEPLS*------------------ 4F8 LLRF-RILP--DHREPRR-T-PEIVLR-AEDGLWLRVEPLG*------------------ 4F11 LLHF-RILP--THIEPRR-K-PELILR-AEGGLWLRVEPLGANSQ*-------------- 4F12 LLHF-RFLP--DHTEPRR-K-LELIMR-AEGGLWLRVEPLNVSLQ*-------------- 4F22 LLRF-RLSV--DRTRKVR---PELILR-TENGLWLKVEPLPPRA*--------------- 4X1 LLHF-RVTP--DPTRPLT-FPNHFILK-PKNGMYLHLKKL*------------------- 4V2 LRHF-WIES--NQKREELGLEGQLILR-PSNGIWIKLKRRNADER*-------------- 46 LQRL-EFRL--VPGQRF-GLQEQATLK-PLDPVLCTLRPRGWQPAPPPPPC*-------- 20 VKRL-HLLS--VEGQVI--ETKYELVT-SSREEAWITVSKRY*----------------- 26A1 ARHC-DWQL---LNGPPT-MKTSPTVY-PVDNLPARFTHFHGE*---------------- 26B1 ASTS-RFELA--TRTFPR-ITLVPVLH-PVDGLSVKFFGLDSNQNEILPETEAMLSATV* 26C1 VRTA-RWELA--TPAFR------------------------------*------------ 11A1 LENF-RVEIQ-HLSDVG-TTFNLILM--PEKPISFTFWPFNQEATQQ*------------ 11B1 LKNF-LVETL-EQEDIK-MVYRFILM--PSTLPLFTFRAIQ*------------------ 11B2 LKHF-LVETL-TQEDIK-MVYSFILR--PGTSPLLTFRAIN*------------------ 27A1 IQKY-KVVLAPETGELK-SVARIVLV--PNKKVGLQFLQRQ*------------------ 27B1 LTHF-EVQPEPGAAPVR-PKTRTVLV--PERSINLQFLDR*------------------- 27C1 LQHF-EIKTSSQTNAVH-AKTHGLLT--PGGPIHVRFVNRK*------------------ 24 VRKY-DIQAT-DNEPVE-MLHSGTLV--PSRELPIAFCQR*------------------- 19 LRRF-HVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH*--------- 8A1 LVHL-DLELINAD--VEIPEFDLSRYGFGLMQPEHDVPVRYRIRP*-------------- 8B1 VTHF-DLELVDPD--TPLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE*------------ 7B1 LTYF-DLEIIDDK---PIGLNY-SRLLFGIQYPDSDVLFRYKVKS*-------------- 7A1 LSYF-ELELIEGQ--AKCPPLDQSRAGLGILPPLNDIEFKYKFKHL*------------- 39 LYKY-DCSLLDP-LPKQSYLHLVGVPQPEGQCRIEYKQRI*------------------- 51 LRLY-EFDLIDG-YFPTV-NYTTMIHTPENPVIRYKRRSK*------------------- 2U1 INSERTION BETWEEN PAGE 2 AND 3? 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