Human P450 sequence collection in FASTA format.  This can be used for blast 
searches at the Do-It-Yourself Blast server.  Just copy and paste this file in 
the second window (without this header) at
http://www.proweb.org/proweb/Tools/WU-blast.html
and seach against all human P450s with a 
BLASTP search.  There are 57 genes and 19 pseudogenes counted here.  There are a 
few pseudogenes that are not counted as separate genes (3A5P1 and 3A5P2 are 
alternative splice variants of 3A5).  There are probably more pseudogenes than
are shown here.  26C1 is now complete. It has highly similar ortholog fragment in Bovine (91% over 68 N-term aa), so it is a real gene and not a pseudogene.
27C1 is also complete. A new 4A22 sequence has been named (95% identical to 
4A11)

Last modified May 23, 2001

>1. CYP1A1 NM_000499
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPW
GWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDD
FKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLE
EHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLV
NLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKG
HIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLV
MNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTR
DTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIF
GMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQM
QLRS

>2. CYP1A2 NM_000761
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPE
PWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQG
DDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCY
LEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLS
LVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFD
KNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLV
TKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTR
DTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMML
FGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQ
ARRFSIN

>3. CYP1B1 NM_000104
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRR
RQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERA
IHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQP
RSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDD
PEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKF
LRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDT
LSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFS
SFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPVKWPNPENFDPARFLDKDG
LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYG
LTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ

>4. CYP2A6 NM_000762
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIG
NYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRG
EQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDAL
RGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQ
LYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQ
EEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
IGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVY
PMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELF
LFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR

>5. CYP2A7 NM_000764
MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIG
NYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRG
EQATFEWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAI
RSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQ
LYEMFSSLMKHLPGPQQQAFKLLLGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ
EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
IGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVF
PMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSIRKRNCFGEGLARMELF
LFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR

Minus Strand HSPs: AC008537.3
Exon 8 is different from 2A7 sequence
Query:     1 MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
             MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK
Sbjct: 73476 MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 73297

Query:    60 KFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFEWVFKGYG 115
             +FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATF+WVFKGYG
Sbjct: 73020 QFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYG 72853

Query:   115 GVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHG 165
             GVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHG
Sbjct: 71895 GVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHG 71743

Query:   165 GANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQL 219
             GANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQ+
Sbjct: 71511 GANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQV 71347

Query:   218 QLYEMFSSLMKHLPGPQQQAFKLLLGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQE 277
             QLYEMFSS+MKHLPGPQQQAFKLL GLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQE
Sbjct: 70205 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQE 70026

Query:   277 EEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAK 326
             +EEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVE K
Sbjct: 69262 QEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEGK 69113

Query:   312 YGFLL----LMKH--PEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 365
             Y FLL    + KH  P   AKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV
Sbjct: 68701 YHFLL*DSQIPKHIPPPPPAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 68522

Query:   366 IPMSLARRVKKDTKFRDFFLPK 387
             IPMSLARRVKKDTKFRDFFLPK
Sbjct: 68521 IPMSLARRVKKDTKFRDFFLPK 68456

Query:   387 KGTEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSIRKRNCF 440
             +GTEVFPMLGSVLRD  FFSNP+DFNPQHFL +KGQFKK DAFVPFSI KR  F
Sbjct: 67937 QGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRPLF 67776

Query:   436 KRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR 494
             KRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR
Sbjct: 67138 KRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR 66962

>1P. CYP2A18PC = CYP2A7PT U22030 and 2A7PC U22044 
364 MLASGLLLVALLASLTVMVLMSVWQQRKSRGKLPLGPTPLLFIGNYLQLNTEHICDSIMK 543
544 ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVTCRT 723
724 WERTKPLRRFSIATLRDFGVGKRGIKE 804
    IQEKAGFLIKAV*GTRGSSIYPTFFLSRTTSNVISSIV 920
921 FGDRFDYEDK 950
950 KFLSLLCMMLESFQFTAPSTGELYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHN 1126
1127 QCTLDPNSPRDFIDSFLIRMQ 1189

>6. CYP2A13 U22028
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIG
NYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRG
EQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDAL
RGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGRFQFTGTSTGQ
LYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQ
EEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRV
IGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVF
PMLGSELRDPRFFSNPQDCSPQHFLDEKGQFKKSDAFVPFSIGKRYCFGEGLARMELF
LFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR

>CYP2A new gene AC058798.1   6 diffs with 2A13 
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYG
VAFNNGERAKHLPRFSIATLRGFGVGKRGIEEHIQEEAGFLIHSLRGTHG

>2P. CYP2A18PN new gene AC008537.2 
QEEKNPNTEFYLKNLVLTTLNLFVGGTETVSTTLHYGFLLLMKHPEVE
AKVHEIDRVIGKNQQPKFEDRAKTLYTEAVIHEIQRFGDLLPMGVSRRVKKDTKFRDFFLSK
GIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSI
GRRNCFREGLARMELFLYLTTIMQNFRFKSRQSPKDIVVSPKHVGFVTIPRNYTKCYLP

This exon is 2G1
Query:    277 QEEKNPNTEFYLKNLVLTTLNLFVGGTETVSTTLHYGFLLLMKHPEVEAK 326
              QEEKNPNTEFYLKNLVLTTLNLFVGGTETVSTTLHYGFLLLMKHPEVE K
Sbjct: 101956 QEEKNPNTEFYLKNLVLTTLNLFVGGTETVSTTLHYGFLLLMKHPEVEGK 101807

Query:    325 AKVHEIDRVIGKNQQPKFEDRAKTLYTEAVIHEIQRFGDLLPMGVSRRVKKDTKFRDFFL 384
              AKVHEIDRVIGKNQQPKFEDRAKTLYTEAVIHEIQRFGDLLPMGVSRRVKKDTKFRDFFL
Sbjct: 101344 AKVHEIDRVIGKNQQPKFEDRAKTLYTEAVIHEIQRFGDLLPMGVSRRVKKDTKFRDFFL 101165

Query:    385 SKGIEVFP 392
              SK + V P
Sbjct: 101164 SKVLHVPP 101141

Query:    385 SKGIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSIGRRNCF 439
              S+GIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSI +R  F
Sbjct: 100644 SQGIEVFPMLGSVLRDLRFFSNPRDFNPQHFLGEKGQFKKRDAFVPFSISKRPLF 100480

Query:   432 SIGRRNCFREGLARMELFLYLTTIMQNFRFKSRQSPKDIVVSPKHVGFVTIPRNYTKCYL 491
             S GRRNCFREGLARMELFLYLTTIMQNFRFKSRQSPKDIVVSPKHVGFVTIPRNYTKCYL
Sbjct: 99926 SSGRRNCFREGLARMELFLYLTTIMQNFRFKSRQSPKDIVVSPKHVGFVTIPRNYTKCYL 99747

Query:   492 P 492
             P
Sbjct: 99746 P 99744

Separate C-term on AC008537.3 minus strand
Query:     1 MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
             MLASGLLLV LLACLTVMVLMSVW+QRKSRGKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 73476 MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 73297

Query:    61 ISE 63
             +S+
Sbjct: 73296 VSQ 73288

Query:    58 LMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYG 115
             L + SE YGPVFTIHLGPRRVVVLCGHDAV+EALVDQAEEFSGRGEQATFDW+FKGYG
Sbjct: 73026 LHQFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYG 72853

gap

Query:   165 GANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGRFQFTGTSTGQL 219
             GANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLL MMLG FQFT TSTGQ+
Sbjct: 71511 GANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQV 71347

Query:   218 QLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQQ 277
             QLYEMFSSVMKHLPGPQQQAFK LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQ 
Sbjct: 70205 QLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQ- 70029

Query:   278 EEKNPNTE 285
              E +P+++
Sbjct: 70028 -EVHPSSQ 70008

gap

Query:   312 YGFLL----LMKH--PEVEAKVHE-IDRVIGKNQQPKFEDRAKTLYTEAVIHEIQRFGDL 364
             Y FLL    + KH  P   AKVHE IDRVIGKN+QPKFEDR K  Y EAVIHEIQRFGD+
Sbjct: 68701 YHFLL*DSQIPKHIPPPPPAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDV 68522

Query:   365 LPMGVSRRVKKDTKFRDFFLSK 386
             +PM ++RRVKKDTKFRDFFL K
Sbjct: 68521 IPMSLARRVKKDTKFRDFFLPK 68456

Query:   432 SIGRRNCFREGLARMELFLYLTTIMQNFRFKSRQSPKDIVVSPKHVGFVTIPRNYTKCYL 491
             S G+RNCF EGLARMELFL+ TT+MQNFR KS QSPKDI VSPKHV F TIPRNYT  +L
Sbjct: 67147 SSGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFL 66968

Query:   492 P 492
             P
Sbjct: 66967 P 66965


>7. CYP2B6 AC023172.1 CDS (hIIB1) join(4116..4286,16811..16973,17107..17256,19715..19875,
22029..22205,22804..22945,25108..25295,25484..25625,
29456..29637) cryptic exon 3A = 18813-18856 (hIIB2)
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFL
RFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA
MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKS
KGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE
LFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEK
SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP
HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL
STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLG KRICLGEGIARAELFLFF
TTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR

AF182277 2B6 related 5 amino acid differences Nov 29 1999 mRNA top seq
Query:     1 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
             MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE
Sbjct:     1 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60

Query:    61 KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120
             KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR
Sbjct:    61 KYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNR 120

Query:   121 WKVLRRFSVTTMRDFGMGKRSVEERTQEEAQCLIEELRKSKGALMDATFLFHSITANIIC 180
             WKVLRRFSVTTMRDFGMGKRSVEER QEEAQCLIEELRKSKGALMD TFLF SITANIIC
Sbjct:   121 WKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIIC 180

Query:   181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNPQE 240
             SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKN QE
Sbjct:   181 SIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQE 240

Query:   241 INAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300
             INAYIGHSVEKHRETLDPSAP+DLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT
Sbjct:   241 INAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGT 300

Query:   301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360
             ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS
Sbjct:   301 ETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFS 360

Query:   361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420
             DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL
Sbjct:   361 DLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGAL 420

Query:   421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480
             KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI
Sbjct:   421 KKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKI 480

Query:   481 PPTYQIRFLPR 491
             PPTYQIRFLPR
Sbjct:   481 PPTYQIRFLPR 491

MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLL
QMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIA
MVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERTQEEAQCLIEELRKS
KGALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE
LFSGFLKYFPGAHRQVYKNPQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEKEK
SNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP
HRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLIL
STALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFF
TTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR

2B7P1 AC008537.2 on two contigs missing last exon There are several ESTs
one in frame stop but this might be an error. Last exon of 2B6 is about 4000bp downstream
fro mthe rest of the 2B6 gene 

Query: 1      MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFRE 60
              MELSVLLFLALLTGLLLLLVQRHPN+H  LPPGPRPLPLLGNLLQMDRRGLLKSFLR R 
Sbjct: 159364 MELSVLLFLALLTGLLLLLVQRHPNSHGTLPPGPRPLPLLGNLLQMDRRGLLKSFLRVRH 159543

Query: 61     K 61
              +
Sbjct: 159544 R 159546

Query: 57     RFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGY----- 111
              +FREKYGDVFTVHLGPRPVVMLCGVEAIREALVD AEAFSGRGKI ++DP ++GY     
Sbjct: 145951 QFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDNAEAFSGRGKIVIMDPVYQGYGEGFR 145772

Query: 112    ---------------------------------------GVIFANGNRWKVLRRFSVTTM 132
                                                     G++FANGNRWKVLRRFSVTTM
Sbjct: 145771 GTGRGQVGVHQGREYMGGRRTQSLLPTSSATNSHLPCTAGMLFANGNRWKVLRRFSVTTM 145592

Query: 133    RDFGMGKRSVEERTQEEAQCLIEELRKSKG 162
              RDFGMGKRSVEER Q+EAQCLIEELRKSKG
Sbjct: 145591 RDFGMGKRSVEERIQDEAQCLIEELRKSKG 145502

Query: 162    GALMDATFLFHSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFE 218
              GAL+D TFLFHSITANIICSI+FGKRFHYQDQEFLK LNLF Q+F LISS+  Q+ E
Sbjct: 143077 GALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFCQSFLLISSISSQVQE 142907

Query: 193    QEFLKMLNLFYQT-FSLISSVFGQLFELFSGFLKYFPGAHRQVYKNPQEINAYIGHSVEK 251
              QE L   +L  Q   +L +  F QLFELFSGFLKYFPGAHRQVYKN QEINAYIGHSVEK
Sbjct: 140821 QEALSPCDLLAQP*ANLTTPSFLQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEK 140642

Query: 252    HRETLDPSAPRDLIDTYLLHMEK 274
              HRETLDPSAPRDLIDTYLLHMEK
Sbjct: 140641 HRETLDPSAPRDLIDTYLLHMEK 140573

Query: 274    KEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVA 321
              +EKSN HSEFSHQNL +NTLSLFFAGTETTSTTLRYGFLLMLKYPHVA
Sbjct: 139983 QEKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVA 139840

Query: 312  LLMLKYPHV---AERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVP 368
            L  +++ H+   AERVY+EIEQV+GPHRPP L DRAKMPYTEAVI EIQRF+DLLPMGVP
Sbjct: 5773 LFKMRFIHLLLCAERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVP 5952

Query: 369  HIVTQHTSFRGYIIPK 384
            HIVTQHTSF GY IPK
Sbjct: 5953 HIVTQHTSF*GYTIPK 6000

Query: 376  SFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGK 433
            SF   I+P+DTEVFLILSTAL DPHYFEKPDAFNPDHFLDANGALKK EAFIPFSLGK
Sbjct: 6166 SFDLVILPQDTEVFLILSTALRDPHYFEKPDAFNPDHFLDANGALKKNEAFIPFSLGK 6339

>3P. CYP2B7P1 = M29873 (hIIB3) 91% to 2B6 One in frame stop, missing last exon
MELSVLLFLALLTGLLLLLVQRHPNSHGTLPPGPRPLPLLGNLLQMDRRGLLKSFLR
FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDNAEAFSGRGKIVIMDPVYQGY
GMLFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQDEAQCLIEELRKSKG
ALVDPTFLFHSITANIICSIIFGKRFHYQDQEFLKTLNLFCQSFLLISSISSQ
LFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPRDLIDTYLLHMEK
EKSNPHSEFSHQNLIINTLSLFFAGTETTSTTLRYGFLLMLKYPHVA
ERVYKEIEQVVGPHRPPALDDRAKMPYTEAVIREIQRFADLLPMGVPHIVTQHTSF*GYTIPK
DTEVFLILSTALRDPHYFEKPDAFNPDHFLDANGALKKNEAFIPFSLGK

>CYP2B7P2 AC011541.5 on chr 19 exon 1 of CYP2B nearly identical to 2B7P
2265 MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 2095

>CYP2B7P3 AC008539.2 on chr 5 lone exon 1 very similar to >CYP2B7 with 3 frame shifts
3359 MELSVLLLLALLTGLLLLLVQRHPNSHGTLPPGPRPLPLLGNLLQMDRRGLLKSFLR 3526

>8. CYP2C8 M17397
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQ
IDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPI
SQRITKGLGIISSNGKRWKEIRRFSLTNLRNFGMGKRSIEDRVQEEAHCLVEELRKTK
ASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNN
FPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFMDCFLIKMEQEKD
NQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRH
RSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLT
SVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLT
TILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV

>9. CYP2C9 M61857
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEA
LIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGC
APCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMN
NPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSH
MPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSA
GKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV

>10. CYP2C18 M61856
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQ
LDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPV
AEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTN
ASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNN
FPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKH
NQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRN
RSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLT
SVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLT
TILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV

>11. CYP2C19 M61854
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQ
IDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPL
AERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTK
ASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNN
FPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQ
NQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRN
RSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLT
SVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT
FILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV

AL138921 Homo sapiens chromosome 10 50% to 2C8
LAMCVTCLIFFLVWKKSPSPTPLPTIGNRLQRNPKD
CISFQLAKEYSSVYTLYFGSWPTMVFHGYKAVKEALIDQGDKSLGRGHIPIIDDAQKRY
TSAQPFDSTFILASAPCNL
CSFLFKECFQYKNETFLSLMGLLNENVK
TTVLPLLSLVLFSYKQFP
GHFLDKNGCFNKTDYFLPFSLGK

AC022650 41% to 2C9 possible pseudogene 2 in frame stops 
note last line may be different gene it is more like 2D6 than 2C9
GIAFSHGETWKTMRRFSLTTLRNFGMGEWIIEDTIIEECQNLIQ
NMFLVLGFLLKSHKTILRNRDELFSFIRMAFLDHHHKLDKNDPRNFTDVFLVTQQE
ENDTFADYFSDKKLVTLVNNLFTTGTETTASTLHWGILLVMRYPEVQS
KVHNEITKVVVSAQS*LAHRTQMTHTDAVI*EVQRFANILPTSLSHATTTNIFKNYCIPK
GTEVIILLASVARDQAQWEKPDTFNPEHFLNSKEKFIKREAFLPF

>12. CYP2D6 NM_000106
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLG
NLLHVDFQNTPYCFDQ LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRP
PVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACL
CAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESG
FLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFL
AEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQE
IDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGMTHMTSRDIEVQGFRIPKG
TTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLAR
MELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR

>4P. CYP2D7AP X58467 assembled to best match 2D6 AL021878 comp(46171-50354)
MGLEALVPLAMIVAIFLLLVDLMHRHQRWAARYPPGPLPLPGLGNLAACGLPEHTILLRP
GLRRRFGDVFSLQLAWTPVVVLNGLAAVREAMVTRGEDTADRPPAPIYQVLGFGPRSQGV
ILSRYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFADQAGRPFRPNGLLD
KAVSNVIASLTCGRRFEYDDPRFLRLLDLAQGGIKEESGFLREVLNAVPVLPHIPALAGK
VLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAKKEKAKGSPESSFNDENLRIVV
GNLFLAGMVTTLTTLAWGLLLMILHLDVQLRVQQEIDDVIGQVRRPEMGDQAHMPYTTAV
IHEVQHFGDLVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWKKPFRFHPEH
FLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVAAGQPRPSHSR
VVSFLVTPSPYELCAVPR*

>5P. CYP2D8P AL021878 comp(55779-60892)
MGLDALVPLAVTVAIFLLLVDLMQQHQRWTARYPPGPLPLPGLGNLLHVDFQNIYTFNQ
LRHRFGDVFSLQLAWMPVVVLNGLAAVREALVTCGEDTADRPPAPIYQVLGIGPRSQ
GVFLAHYGHAWREQRRFSVSTLRNLGLGKKSLERWVTEEAACLCAAFADQA
GRPFHPNGLLNKAASNVIASLTCGCRFEYDDPRFLRL
LDLAQKGLKEELGFL*E
MLNVVPLLLRIPGLAGKVLRSQKAFLTQLDELLTEHRMIWDPA*PPRDLTEAFLAEKEK
AKGNPESSFNDENLRMVVADLFFAGMVTTSITLAWGLLLMILRPDVQ
XXXQQIDNVIGQVW*PEMGDQARMPCTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPK
GMMLFTNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKLEAFLPFSAG
RRACLGEPLARIELFLFFTSLLQHFSFSVPTGQPRPSHSRVVGFLVTPSPYELCAVPR

>13. CYP2E1 J02843
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGN
LFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGD
LPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRK
TQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLY
NNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKE
KHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIG
PSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPT
LDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLL
LCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS

>14. CYP2F1 J02906
MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLL
LLCSQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYP
AFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLADVRKT
EGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYD
ILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASSPRDFIQCFLTKMAEEK
EDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGR
ARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLL
NTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGELLARMELFLYL
TAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRPR

AC008537.3 93% identical to 2F1
Query:   162 GEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGEL 216
             GEPFDPTFVLSRS SNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGE+
Sbjct: 49919 GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGEV 49755

Query:   209 MSSPWGELYDILDPRFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQAS----SPRDF 264
             +S P  +LYDI    FPSLL+WVPGPHQRIFQNFKCLRDLIAHSVHDHQAS    SPRDF
Sbjct: 49434 LSGP--QLYDI----FPSLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDF 49273

Query:   265 IQCFLTKMAE 274
             I CFLTKMAE
Sbjct: 49272 IHCFLTKMAE 49243

Query:   274 EEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQ 321
             ++KEDPLSHFHMDTLLMTTHNLLFGGT+TV TTL HAFLA MKYPKVQ
Sbjct: 48411 QKKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLAFMKYPKVQ 48268

Query:   318 PKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAF 377
             P   A VQEEI+LVVG  RLPALKDRAAMPYTD VIHEVQRFADIIPMNLPHR+TRDTAF
Sbjct: 45559 PSPPAHVQEEINLVVGHVRLPALKDRAAMPYTDMVIHEVQRFADIIPMNLPHRITRDTAF 45380

Query:   378 RGFLIPK 384
              GFLIPK
Sbjct: 45379 HGFLIPK 45359

Query:   384 KGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAG 432
             +GTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAG
Sbjct: 44775 QGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAG 44629

Query:   431 AGRRLCLGELLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRP 490
             AG RLCLGE LARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCL P
Sbjct: 42050 AGHRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLHP 41871

Query:   491 R 491
             R
Sbjct: 41870 R 41868

GEPFDPTFVLSRSRSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGE
LYDIFPSLLNWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIHCFLTKMAE
KKEDPLSHFHMDTLLMTTHNLLFGGTETVGTTLRHAFLAFMKYPKVQ
AHVQEEINLVVGHVRLPALKDRAAMPYTDMVIHEVQRFADIIPMNLPHRITRDTAFHGFLIPK
GTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAG
HRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLHPR


>6P. CYP2G1P AC008537 missing exons 4, 5 and 6 
MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK
LREKYSPVFTVYMGPRPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG
VALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK
AKIHEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGRGK
RICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR


Query:     1 MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK 60
             MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK
Sbjct: 82485 MELGGAVTIFLALRLSCLLILIAWKRMDKAGKLPPGPTPILFLGHLLQVRTDATFQSFMK 82664

Query:    60 KLREKYSPVFTVYMGP 75
             KLREKYSPVFTVYMGP
Sbjct: 83254 KLREKYSPVFTVYMGP 83301

Query:    74 GPRPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG 115
             G RPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG
Sbjct: 83295 GSRPVVVLCGHEAVKEALIDQADEFSGRGELASIKQNFQGHG 83420

Query:   115 GVALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK 164
             GVALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK
Sbjct: 85109 GVALANGERWRILRRFSLTILRDFGMGKQSIKERIQEEASYLLEEFQKTK 85258

Query:   216 HEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK 275
             HEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK
Sbjct: 89412 HEEINQVIGPHRLPRVDDRVKMPYTDVVIHEIQRLVDIVPMGVPHNIIQDTQFRGYLLPK 89591

Query:   274 PKGTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGR 324
             P+GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGR
Sbjct: 89697 PQGTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGR 89849

Query:   325 GKRICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR 384
             GKRICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR
Sbjct: 91239 GKRICLGEAMARMELFLYFTSTLQNFSLCSLVPLVDIDITPKLSGFGNITPTYELCLVAR 91418


>7P. CYP2G2P AC008962 comp(28700-40696) seq of gene has two in frame stop codons
MEMGGAVTIFLALCLSCLLILIAWK*MNKAGKLPPGPTPIPFLGNLLQVRTDATFQSFMK
LREKYSPVFTVYMGPRPVVVLCGHEAVKEALVDQADEFSGRGELASIKQNFQGHG
VALANGERWRIL*RFPLTILRDFGMGKRSIEERIQEEASYLLEEFRKTK
GAPIDPIFLLSRTVSNVISSVVFRSRFDYEDKQFLNLLRLINESFIEMSTPWAQ
LYDMYSGIMQYLPGRHNLIYYLVEELKDFIASRVKINEASFDPQNPRDFIDCFLIKMH
QDKNNPRTEFNLKNLVLTTLNLFFAGTETVSSTLRYGFLLLMKHPEVE
AKIHEEINQVIGPHRLPRVDDRVKMPYTDAVIHEIQRLVDIVPMGVPHNLIRDTQFRGYLLPK
GTDVFPLLGSVLKDPKYFRYPDAFYPQHFLDEQGRFKKNEAFVPFSSGR
GKRICLGEAMDRMELFLYFTSTLQNFSLHSLVPPVDIDITPKLSGFGNIPPTYELCLVAR*

>15. CYP2J2 NM_000775
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYP
PGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALI
HMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQ
EEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEV
TYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRD
FIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQ
EKVQVEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPQNVPREVTVDTTLAG
YHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLG
EQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLC

>16. CYP2R1 Mikael Oscarson AC018795.4 also AC025730 AC025748 EST AA663042
108124 MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIY
       SLAASSELPHVYMRKQSQVYGE 107900
 96334 IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSR
YGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVS
NITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFR
NAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELI
IAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEV
LRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDS
SGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMT
LQPQPYLICAERR 104126

>17. CYP2S1 AC011510 one exon per line 78% to mouse 2s1 49% to 2B6 47% to 2A13
MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMR
LSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGH
GVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTE
GRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQ
TYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQ
EEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQ
KWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQ
GTEVFPLLGSILHEPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSL
GKRVCLGEGLAKAEVFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR

>8P. CYP2T2P AC008537
RAQMRGSLPPRPRPLPLLGNL
QLQSGGLDRALHSLSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADA 
VSGRGSMAVFERFTRGNGILFSNRPCWWTLRNFALGALKKFGLGTRTVEA 
RVLEEAACLLDEFQATIGAPFDPVRLLDNAVSNVICSLVFGNRYRYGDPE 
FLRLLNLFSDNFCIISSRWGESLMDWLPGPHHRIFRNFSE 
LRVISEQIQRHWQMRQPAEPRDFIDCLTRWVRHGQQDPESHFQE*TSVM 
TTHFFFGVTETTSTTLCYGLLILLKYLEVAAKVQELDPVVGWRPAPSL 
DYRVCLPYANAVLLEIQCFISVVPLGLPRTLTLDTHLHSHCLPKGTFVIP 
LLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAFMPFAPAKQMCLG 
TGLAHSGIFLFLTATLQRFCLLPVVRPGTINLTQCTGLGSVPPDFQLQPVAC 

Query:     1 RAQMRGSLPPRPRPLPLLGNLQLQSGGLDRALHSLSGRWG 40
             RAQMRGSLPPRPRPLPLLGNLQLQSGGLDRALHS    WG
Sbjct: 35169 RAQMRGSLPPRPRPLPLLGNLQLQSGGLDRALHSRQ-EWG 35053

Query:    35 LSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADAVSGRGSMAVFERFTRGN 88
             LSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADAVSGRGSMAVFERFTRGN
Sbjct: 34537 LSGRWGRVFTVRLGPRPAVGLCGYAALRDALVLQADAVSGRGSMAVFERFTRGN 34376

Query:    89 GILFSNRPCWWTLRNFALGALKKFGLGTRTVEARVLEEAACLLDEFQATIGA 140
             GILFSNRPCWWTLRNFALGALKKFGLGTRTVEARVLEEAACLLDEFQATI +
Sbjct: 33958 GILFSNRPCWWTLRNFALGALKKFGLGTRTVEARVLEEAACLLDEFQATIAS 33803

Query:   139 GAPFDPVRLLDNAVSNVICS 158
             GAPFDPVRLLDNAVSNVICS
Sbjct: 33643 GAPFDPVRLLDNAVSNVICS 33584

Query:   159 LVFGNRYRYGDPEFLRLLNLFSDNFCIISSRWGE 192
             LVFGNRYRYGDPEFLRLLNLFSDNFCIISSRWGE
Sbjct: 33585 LVFGNRYRYGDPEFLRLLNLFSDNFCIISSRWGE 33484

Query:   193 SLMDWLPGPHHRIFRNFSELRVISEQIQRHWQMRQPAEPRDFIDCLTRWVRHGQQ 247
             SLMDWLPGPHHRIFRNFSELRVISEQIQRHWQMRQPAEPRDFIDCLTRWVRHG Q
Sbjct: 33251 SLMDWLPGPHHRIFRNFSELRVISEQIQRHWQMRQPAEPRDFIDCLTRWVRHGSQ 33087

Query:   246 QQDPESHFQE*TSVMTTHFFFGVTETTSTTLCYGLLILLKYLEVA 290
             QQDPESHFQE*TSVMTTHFFFGVTETTSTTLCYGLLILLKYLEVA
Sbjct: 33011 QQDPESHFQE*TSVMTTHFFFGVTETTSTTLCYGLLILLKYLEVA 32877

Query:   291 AKVQELDPVVGWRPAPSLDYRVCLPYANAVLLEIQCFISVVPLGLPRTLTLDTHLHSHCL 350
             AKVQELDPVVGWRPAPSLDYRVCLPYANAVLLEIQCFISVVPLGLPRTLTLDTHLHSHCL
Sbjct: 32780 AKVQELDPVVGWRPAPSLDYRVCLPYANAVLLEIQCFISVVPLGLPRTLTLDTHLHSHCL 32601

Query:   351 PKGT 354
             PKGT
Sbjct: 32600 PKGT 32589

Query:   349 CL-PKGTFVIPLLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAFMPFA 397
             C+ P+GTFVIPLLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAFMPFA
Sbjct: 32086 CMYPQGTFVIPLLVTAHRDPTQFKDPDCFNPTNFLDKGKFQGNDAFMPFA 31937

Query:   395 PFAPAKQMCLGTGLAHSGIFLFLTATLQRFCLLPVVRPGTINLTQCTGLG-SVPP 448
             P  PAKQMCLGTGLAHSGIFLFLTATLQRFCLLPVVRPGTINLT C+ L  +V P
Sbjct: 31867 PVYPAKQMCLGTGLAHSGIFLFLTATLQRFCLLPVVRPGTINLT-CSALAWAVSP 31706

Query:   439 QCTGLGSVPPDFQLQPVAC 457
             QCTGLGSVPPDFQLQPVAC
Sbjct: 31733 QCTGLGSVPPDFQLQPVAC 31677


>9P. CYP2T3P AC008962 C-terminal missing
RAQMRGSLPPRPRLLPLLGNLQLQSGGLDRALHS
LSGRWGRVFTVRLGPRPAVVLCGYAALRDALVLQADAVSGRGSMAVFERFTRGN
GILFSNRPCWWTLRNFALGAPKKFGLDTRTIEARVLDEAACLLDEFQATI
GAPFDPVRLLGNAVSSVTCSCLREPLWLRGPGVPEVLNLLSDNFRIMSSKWGE probable frameshift here
SLMDWLPGPHHQIFQNFSELQVFISEQIQQHWHMRQPAEPRDFIDCLARWVRHG
QQDPESHFQEETLVMTMQLFFFFFFGGTETTSTTLC
AKGQELDPVVGQRPVPSPD
DHVQWPYTNAVLLEIQRFISVVPRTLTLDTHLHSHCLAKG

>18. CYP2U1 AC025090, (AC000016 has C-term) 41% to 2N1 new >CYP2 subfamily
intron joints not yet defined
MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGI
77036 PPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSI 76863
76862 FSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVT 76734
105008 GPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPF 105160
105161 SIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPF 105340
105341 GPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEE 105517
105518 YLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQ 105622
107396 KVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENT 107554
109370 LQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIG 109540
KRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR

>19. CYP2W1 AC073957.3 chromosome 7 clone RP11-449P15 40% to 2F1
MALLLLLFLGLLGLWGLLCACAQDPSPAARWAPGLRPLPLVGNLHLLRLSQQDRSLME 
LSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRP
PIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQL
DGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL
FNVHPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQG
DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGP
GRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLT
SVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSA
GRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRPRALCAVPRP*

The following cDNA has been reported from Japan in a project to identify 
Full length cDNAs.  This is a part of the 2W1 gene.  The reported 
sequence shown below is not full length.  It is missing the N-terminal 
exon and the C-terminal exon. If one translates the sequence upstream of 
the ATG shown below, one finds the N-terminal exon sequence as shown 
above, however, there are only about 7 amino acids worth before the 
sequence runs out and stops. Similarly, if the genomic clone is searched 
downstream of the end of the cDNA, a clear heme binding sequence is 
found and another exon is identified.  The last exon has a problem.  It 
is too long if allowed to run until it hits a natural stop codon.  
However, in another frame there is a sequence LCAVPRP* that is identical 
to the end of CYP2D6 and this sequence is at the right location for this 
to be the end of the 2W1 gene.  I suspect there is a frameshift between 
the heme binding region and the LCAVPRP* sequence.  I have shown the 2W1 
gene with this frameshift, though the exact location is uncertain.

AK000366.1 Homo sapiens cDNA FLJ20359 fis, clone HEP16626
MELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRP
PIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQL
DGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQL
FNVHPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQG
DDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGP
GRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLT
SVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGQQPSGPGWGGTSRAPGVGR
PQLRLPPLHPPPDLRF"

>20. CYP3A4 J04449
MAVIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPL
PFLGNILSYHKGFCMFDMECHKKYGKVCGFYDGQQPVLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSIIFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMID
SQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI
DAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGWV
VMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYTYTPFGSGPRNCIGMRFALMN
MKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA

>21. CYP3A5 NM_000777
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL
PLLGNVLSYRQGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVF
TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL
RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP
LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI
DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE
IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS
MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN
MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE

>CYP3A5P1 L26985 cDNA these seem to be derived from the 3A5 gene
by incomplete processing not from a separate gene location
  72 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 251
 252 DTECYKKYGKMWGT 293
 414 YEGQLPVLAITDPDVIRTVLVKECYSVFTNRR 521
 630 SLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEKRHHKIHYKMSLTAPCWRKPY 806
 807 PSGT*VCTFNYSIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLS 986
 987 IILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSK 1166
1167 ETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 1346

>CYP3A5P2 X90579 these seem to be derived from the 3A5 gene
by incomplete processing not from a separate gene location
  79 MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF 258
 259 DTECYKKYGKMWG 297
 430 TYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSL 606
 607 LSPTFTSGKLKEKRHHKIHYKMSLTAPCWRKPYPSGT*VCTFNYSIFGAYSMDVITGTSF 786
 787 GVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFL 966
 967 SKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYET 1146
1147 TSSVLSFTLYELATHPDVQQKLQKEIDAVLPNK 1245

NSQPSKQQHSAKRKTHRTQLKKESGDGPHPKFGGGNLASPGCQPGAPLSIWDPYTWTF*ETGNSRAHTSAFVGKCFVLSSGSLEI*HRVL*KVWKNVGY
LFPVWTTLPFII*SLGWLLCETLAVCHTLMN*NLRLLCVVQLGN
V*RSTPCAGHHRSRRDQNSASERMLFCLHKSKVFRPSGIYEKCHLFS*G*RMEENTVIAVSNLHQRKTQGEKTSQNSLQNVTYCSMLEKAISFWDLSLHI*LQHLWGLQHGCDYWHIIWSEHRLSQQSTRPLCGEH*EVPKIWFLRSIISLNNTLSIPYPSF*SIKCLSVSKRYHKFFK*ICKQNEEKSPQRQTKAPTRFPSADD*LPEFERN*VPQSSV*SGARSPVNNLHFCWL*NHQQCSFLHFI*TGHSP*CPAETAKGD*CSFAQ*GEGMTPGDEGKR*SLSKNASSPLPRRIFIKSIITDSFTDIM*EASEEKNKGRNIENGCYWQKHKIFVQYCWPWFTCLLLSQ*C*V

EFPAQQTAALS*KEDSQNTAEEGKWRWTSSQIWRWKPGFSWLSAWCSSIYMGPVHMDFLRDWEFQGPHLCLCWEMFCPIVRVSGNLTQSAIKSMEKCGV
SLPCLDHITLHHMKPWVAPV*DSCCVSHPNELEPKVAVCRTTRE
RMKVNSLCWPSQIPT*SEQC**KNVILSSQIEGL*AQWDL*KVPSL*LRMKNGREYGHCCLQPSPAENSRRKDITKFITKCHLLLHAGESHILLGLESAHLTTASLGPTAWM*LLAHHLE*TSTLSTIHKTPLWRALRSS*NLVS*IHYFSQ*YSFHSLPQFLKH*MSLCFQKIP*IF*VNL*TE*RKVASTTNKSTD*ISFS**LTPRIRKKLSPTKLCLIWSSQPSQ*SSFLLAMKPPAVFFPSLYMNWPLTLMSSRNCKRRLMQFCPIR*GDDPWR*REEVKP*QKCLLTTPQENFYKKHNH*FLH*HNVGSL*GEKQREKHRERLLLAEA*DLCTILLALVHLFTVITIMLS

GIPSPANSSTQLKGRLTEHS*RRKVAMDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKFDTECYKKYGKMWG ISSLFGPHYPSSYEALGGSCVRLLLCVTP**TRT*GCCVSYN*G
TYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEKRHHKIHYKMSLTAPCWRKPYPSGT*VCTFNYSIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKVRG*PLEMKGRGEALAKMPPHHSPGEFL*KA*SLIPSLT*CRKPLRRKTKGET*RTVATGRSIRSLYNIAGPGSPVYCYHNNAK*

>22. CYP3A7 NM_000765
MDLIPNLAVETWLLLAVSLILLYLYGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA

>23. CYP3A43 AC011904 one exon per line
MDLIPNFAMETWVLVATSLVLLYI
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR
GLWNFDRECNEKYGEMWG
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE
MVPIISQCGDMLVRSLRQEAENSKSINLKE
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK
HRVDFFQQMIDSQNSKETKSHK
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP

>24. CYP4A11 NM_000778 12 exons BG533264 BF594611 W84867 W84868 
T83194 T83178 R10514 all 100% 4A11
MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQE(0)
LQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRS (1)
DPKSHGSYRFLAPWI (1)
GYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVML (0)
DKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR (2)
NSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHT (1)
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK (0)
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITW (2)
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG (1)
IMVLLSIYGLHHNPKVWPNPEV (0)
FDPSRFAPGSAQHSHAFLPFSGGSR (2)
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL*

>CYP4A22 new 4A11 like sequence AL390073.5 95% identical to 4A11 see alignment below
MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQE
FQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYKFLAPRI
GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDR
NSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG
IMVLLSIYGLHHNPKVWPNLE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL*

>gi|13638032|ref|XM_010591.2| Homo sapiens cytochrome P450, subfamily IVA, polypeptide 11
           (CYP4A11), mRNA
          Length = 2816
This mRNA matches the new 4A11 like sequence but it was assembled from genomic DNA
This is not an mRNA sequence but a computer based assembly
 Score =  972 bits (2513), Expect = 0.0
 Identities = 479/519 (92%), Positives = 488/519 (93%)
 Frame = +1

Query: 1   MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60
           MSVSVLSPSR LG VSGILQ  SLLILLLLLIKA QLYLHRQWLLKALQQFPCPPSHWLF
Sbjct: 313 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 492

Query: 61  GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120
           GHIQE Q DQELQRIQ+ V+TFPSACP+W+WGGKVRVQLYDPDYMKVILGRS        
Sbjct: 493 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSXXXXXXXX 672

Query: 121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180
                   YGLLLLNGQTWFQHRRMLTPAFH DILKPYVGLMADSVRVMLDKWEELLGQD
Sbjct: 673 XXXXXXXXYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 852

Query: 181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240
           SPLEVFQHVSLMTLDTIMK AFSHQGSIQVDRNSQSYIQAISDLN+LVF  +RNAFH+ND
Sbjct: 853 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 1032

Query: 241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300
           TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
Sbjct: 1033TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 1212

Query: 301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360
           ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGAS
Sbjct: 1213ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 1392

Query: 361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420
           ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
Sbjct: 1393ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 1572

Query: 421 NPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480
           NPKVWPN EVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMN+LKVA ALTLLRFEL
Sbjct: 1573NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 1752

Query: 481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL 519
           LPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL
Sbjct: 1753LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL 1869

>CYP4A new seq (top) vs CYP4A11 NM_000778 (bottom) 12 exons
       Length = 520

 Score = 2607 (917.7 bits), Expect = 1.1e-276, P = 1.1e-276
 Identities = 494/520 (95%), Positives = 504/520 (96%)

Query:     1 MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLF 60
             MSVSVLSPSR LG VSGILQ  SLLILLLLLIKA QLYLHRQWLLKALQQFPCPPSHWLF
Sbjct:     1 MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLF 60

Query:    61 GHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120
             GHIQE Q DQELQRIQ+ V+TFPSACP+W+WGGKVRVQLYDPDYMKVILGRSDPKSHGSY
Sbjct:    61 GHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSY 120

Query:   121 KFLAPRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQD 180
             +FLAP IGYGLLLLNGQTWFQHRRMLTPAFH DILKPYVGLMADSVRVMLDKWEELLGQD
Sbjct:   121 RFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQD 180

Query:   181 SPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHEND 240
             SPLEVFQHVSLMTLDTIMK AFSHQGSIQVDRNSQSYIQAISDLN+LVF  +RNAFH+ND
Sbjct:   181 SPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQND 240

Query:   241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300
             TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM
Sbjct:   241 TIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKM 300

Query:   301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGAS 360
             ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIH LLGDGAS
Sbjct:   301 ENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGAS 360

Query:   361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420
             ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH
Sbjct:   361 ITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHH 420

Query:   421 NPKVWPNLEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL 480
             NPKVWPN EVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMN+LKVA ALTLLRFEL
Sbjct:   421 NPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFEL 480

Query:   481 LPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL* 520
             LPDPTRIPIP+ARLVLKSKNGIHLRLRRLPNPCEDKDQL*
Sbjct:   481 LPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL* 520

>25. CYP4A20 AJ131016 AC026935 161971-176942 52% to 4A11 52% to 4X1
45% to 4B1 39% to 4F2
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDRS
SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
HLEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV

>26. CYP4B1 NM_000779
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRRTLAKAMD
KFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKA
VYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTES
TRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDL
TLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKK
IQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY
PEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVT
FVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGP
RNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPG
SGK

>27. CYP4F2 NM_001082 alternative 2nd exon
MSQLSLSWLGLCDVAASPWLLLLLVGASWLLAHVLAWTYAFYDN
CRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLC
HPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL
KPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
SEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA
SVSPGSCTTLQSTQNTRSVCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRCI
PPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENI
KERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLAFRVLPDHTEPRRSRSWSCAQ
RADFGCGWSP

>28. CYP4F3 NM_000896
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDN
CCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIF
HPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNIL
KPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
SEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDDVIQERRR
TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA
SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLH
PPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNI
KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVLPDHTEPRRKPELVLRA
EGGLWLRVEPLS

>29. CYP4F8 NM_007253
MSLLSLSWLGLRPVAASPWLLLLVVGASWLLARILAWTYAFYHN
GRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLC
HPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNIL
KPYIKIFSKSANIMHAKWQRLAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKP
SEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRR
TLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTA
SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLH
PPIPTFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENA
QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRA
EDGLWLRVEPLG

>10P. CYP4F9P     HUMAN AC004609 complement(13903-33104 region)
            pseudogene N-terminal not on this cosmid, may be on adjacent cosmid
            missing 71 amino acids at N-terminal
            69% identical to 4F3 67% identical to 4F8
            sequence overlaps AC004790 but is missing N-term
EGMRVLTQLVATYPQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKD
EAFYKFLKPWLGDGLLVNASDKWSCHRQMLMPAFHFNMLKPYMKFFTDSV
NIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQKCVFSFDSHCQEKPSQYIATI
LELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVHDFTEAIIQEQRH
TLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXXXXXX
GHNTTASGLSWVLYYLARHPEYQEHCWQEVQKLLKDHEPKEIEX
DDLAQLPFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLF
SNFETHHNPTVWLDPEVYDPFRFDPENSKERSPLAFIPFSAGSX
NCIGQAFAMAEMKVVLALTLLCFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS

>11P. CYP4F10P   human AD000685 exons 3-6 (cosmid ends in middle of exon 6) 
           49350 to end of cosmid.  Cannot recognize exons 1 and 2 after 4F3 gene 
           ends at 44623 and before exon 3 starts at 49350.  May be a pseudogene (No ESTs)
SATIAPKDKVFYSFLKPWLG
DGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNIMH
AKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQE
KPSEYIASVLELSSLVAKRNQQ

>30. CYP4F11 N-terminal is on AC011517 rest is on AC020950
MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQC
FPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLI
LCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRML
TPAFHFNLKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDS
LQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQR
FRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD
EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEV
QELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG
RVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGP
RNCIGQAFAMAEMKVVLALTLLHFRILPTHIEPRRKPELILRAEGGLWLRVEPLGANSQ

>31. CYP4F12 GenEMBL AC004523  missing N-terminal
ITPTEEGLKNSTQMSATYSQGFTIWLGPIIPFIVLCHPDTIRSI
TNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFN
KSANIMLDKWQHLASEGSSCLDMFEHISLMTLDSLQKCIFSFDSHCQERPSEYIATIL
ELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGID
DFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLY
NLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISR
CCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAF
IPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRAEGGLWLRV
EPLNVSLQ

LOCUS       AB035130     1694 bp    mRNA            PRI       21-NOV-2000
DEFINITION  Homo sapiens CYP4F12 mRNA for cytochrome P450, complete cds.
ACCESSION   AB035130
AUTHORS     Hashizume,T., Imaoka,S., Funae,Y., Miyazaki,H., Mise,M.,
            Terauchi,Y., Fujii,T. and Sekine,Y.
  TITLE     A novel human cytochrome P450 involved in the metabolism of
            ebastine in small intestine

MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNN
CRRLQCFPQPPKRNWFWGHLGL
ITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLC
HPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNIL
KSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP
SEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR
TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTA
SGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENS
KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRA
EGGLWLRVEPLNVGLQ

>32. CYP4F22 AC011492 assembled gene 13 exons 114537-140651 66% to 4F3, 65% to 4F11, 63% to 4F2,
59% to 4F8, 64% to 4F12, 57% to AC011537 exact intron boundaries need checking no ESTs
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMVS
PNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGAS
AAIAPKDDLFYGFLKPWLG
DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMH
AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQE
KMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRR
ALRQQGAEAWLKAKQGKTLDFIDVLLLAR
DEDGKELSDEDIRAEADTFMFEG
HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW
DDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPK
GIICLVSIYGTHHNPTVWPDSK
VYNPYRFDPDNPQQRSPLAYVPFSAGPR
NCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRRKPELILRTENGLWLKVEPLPPRA*

>12P. CYP4F23P AC011492 assembled gene 76% to 4F3, 76% to 4F8, 76% to 4F11, 73% to 4F2, 75% to 4F12, 77% to
4F11, 60% to other 4F on this accession no ESTs also on AD000091
MSLLSLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYAFYDNCHRLQCFQQPPKRNCF*GHLSLVS
GNEEDMRLMEDLGHYFRDVQLWWLGSFYPVLHLVHPTFTAPVLQAS AAVALKDMSFYGFLKPWLG
DGLLISAGDKWRWHRHLLTPAFHFKILKPYVKIFNESTNIMH
AKWQRLALEGSVRLEMFEHISLMTLDSLQKCIFSFDSNCQE
KPSEYIDAILELSALSLKRHQHIFLLTDFLYFLTPNGRRFCRACDIVHNFTDAVIQERRR
TLTSQGVDDFLQAKAKSKTLDFIDVLLLAK DENGKKLSDENIRAEADTFMSG
GHDTTASGLSWVLYNLARYPEYQEHCRQEVQELLKNGDPKEIEW
DDLAQLPFLTMCLKESLRLHSPVSRIHRCCPQDGVLPDGRVIPK GNTCTISIFGIHHNPSVWPDPEV
YDPFRFDPENLQKTSPLAFIPFSAVPR
NCIGQTFAMAEMKVVLALTLLRFRVLPDHAEPRRKLELIVRAEDGLWLRVEPLSADLQ* 

>13P. CYP4F24P AC011537 77% to 4F11
24346 MPQLSLSWLGLGQVAAFPWLLLLLAGASRLLAGFLAWTYAFYDNCRRLQYFPQPPKQKWF 24167
24166 WGQPGX 24152
6633 IIATEEGLKNLTQMSATYPQGFRIWLGPIFPFIVLCHPDIVRSITNAS 6788
8837 AAIAPKDDLSIRFLKPWLGEGILLSGGDK 9016
9017 WSRHRRMLTPAFHFNILKPYIKIFNRSVNIMH 9112
11018 DKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 11140
11921 RPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGWRFRRACRLVHDFTDAVIQERRH 12100
12101 TLPTQGI 12121
12115 CDFLKNKAKS*TLDFIDVLLLSK 12189
      DEDGKVLSDEDVRAEADTFMAG
13460 GHDTTASGLSWVLYNLARHPEYQEHCRQEVQELLKDRDPKEIEWX 13591
21804 DLAQLPFLTMCVKESLRLHPPVPYTSRHRIWDIVLPDGRVIPK 21932
22019 GIICIINIIGIHHNPTV*PDPEV 22165
22263 YNPFRFNSENSKERSPLAFIPFSAGPR 22361

>14P. CYP4F25P AC018949 62% to 4F3 pseudogene
95242 LWRCFLSPTSPCRNPSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDL 95066
95065 VHNF 95054
95052 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 94936

>15P. CYP4F26P AL139008 Homo sapiens chromosome 9 clone RP11-255A11 81% TO 4F25P
SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF FRAME SHIFT
DTIILEQHCTLTSQSVDILKARATFKTLDFIDALVLSK

>16P. CYP4F27P AC018804.2 Homo sapiens clone RP11-397H17 62% TO >CYPF25P
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171

>17P. CYP4F28P chr 21 AL109748 designated >CYP4F3LP pseudogene in Nature 405, 311-319 2000 (May 18) 81% to 4F25P 80% to 4F26P
3607 (218)PSEYIATLFELSALIV*WHQQICLCMDFLYYPF (250) 3705
3705 (251)PEG*CFCRACDLVHNF(266) 3752
3754 (268)DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK (306) 3870
4197 (307)DENGKELSDEDI*MEAGIFMST(330) 4265
4440 (329)GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW(372) 4562

>33. CYP4X1 R56515, R53456, AA652746, AC026935
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQK
FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP
LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE
VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK
LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDES
GSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSIT
WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP
AVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV
TPDPTRPLTFPNHFILKPKNGMYLHLKKL

>34. CYP4V2 formerly CYP4AH1 AC012525 Homo sapiens chromosome 4
69% identical to 4V1 of rainbow trout 64% to AW019701 zebrafish EST
223491 MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGR 223279
220816 EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEG 220700
219309 ILTSSKQIDKSSMYKFLEPWLGLGLLT 219232
218377 STGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIIC 218186 
217783 ETAMGKNIGAQSNDDSEYVRAVYR 217712
216357 MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSV 216229
214155 IAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE 213973
210091 GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV 209993
206422 KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSED
206248 YFLTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQG 206069
206068 RHPYAYVPFSAGPRNCIG 206015
204818 QKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER* 204648

>35. CYP5A1 NM_001061 this gene is 197000 bases long
MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLG
LRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLV
ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQAC
DLLLAHLKRYAESGDAFDIQRCYCNYTTDVVASVPFGTPVDSWQAPEDPFVKHCKRFF
EFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERR
RDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVG
QAFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLP
YLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE
TFNPERFTAEARQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPE
TQVPLQLESKSALGPKNGVYIKIVSR

>36. CYP7A1 NM_000780
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGC
ALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF
ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN
SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA
LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKA
KTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPIC
LSQAELNDLPVLNSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQ
LMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA
IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL

>37. CYP7B1 NM_004820
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPG
EPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLV
IKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN
LKQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLK
FDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYV
HEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKG
SGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDL
VAIFPPVLHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCP
GRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRYKVKS

>38. CYP8A1 D83402
MAWAALLGLLVALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYAL
DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIF
LMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH
EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLA
RGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARA
LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV
LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ
RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS
IKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP

>39. CYP8B1 AF090318 AC010192
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGT
VPWLGHAMAFRKNMFEFLKRMRTKHGDVFTVQLGGQYFTFVMDP
LSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQGDHEMIHSASTKHLRGDGLKDLNE
TMLDSLSFVMLTSKGWSLDASCWHEDSLFRFCYYILFTAGYLSLFGYTKDKEQDLLQA
GELFMEFRKFDLLFPRFVYSLLWPREWLEVGRLQHLFHKMLSVSHSQEKEGISNWLGN
MLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLYLLKHPEAIRAVREEATQV
LGEARLETKQSFAFKLGALQHTPVLDSVVEETLRLRAAPTLLRLVHEDYTLKMSSGQE
YLFRHGDILALFPYLSVHMDPDIHPEPTVFKYDRFLNPNGSRKVDFFKTGKKIHHYTM
PWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQRWGFGTMQPSH
DVRFRYRLHPTE

>40. CYP11A1 NM_000781
MLAKGLPPRSVLVKGYQTFLSAPREGLGRLRVPTGEGAGISTRS
PRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI
DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA
PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER
QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK
ADIYTQNFYWELRQKGSVHHDYRGMLYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT
LQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISV
TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYF
RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS
FTFWPFNQEATQQ

>41. CYP11B1 NM_000497
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRR
PGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQ
VDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPM
VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS
ASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQ
ELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP
NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL
QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC
LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMCPLLTFRAIN

>42. CYP11B2 NM_000498
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQH
PGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQ
VDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPM
VDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS
ASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ
ELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNP
DVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL
QNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQC
LGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN

>43. CYP17 NM_000102
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL
DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV
PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST

>44. CYP19 NM_000103
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGT
SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSS
MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRM
VTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQ
GYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRCRISTEEKLEECM
DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIK
EIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAI
LVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH

>45. CYP21A2 M26856
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPD
LPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVS
RNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVA
IEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRF
FPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQ
LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSR
VPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGA
HLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF
TLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ

>46. CYP20 AC011737.8 chromosome 2 (missing exons 12, 13)
also AC080075.2  (missing exons 1,7,8)
MLDFAIFAVTFLLALVGAVLYLYP (0)
ASRQAAGIPGITPTEEK (2)
DGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTS (1)
DPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLLK (0)
LSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGT (0)
VWSEIGKGFLDGSLDKNMTRKKQYED (1) 
ALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQ(0) 
ILEDSMIFSLASCIITAK (1) 
LCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLR (2)
YCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRE (0) 
TLVLYALGVVLQDPNTWPSPHK (2) 
FDPDRFDDELVMKTFSSLGFSGTQECPELR (2) based on AC080075.2 and fish genomic DNA
FAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY

>47. CYP24 NM_000782
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVC
PLTAGGETQNAAALPGPTSWPLLASLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLG
SFESVHLGSPCLLEALYRTESVPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSA
FQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVL
YEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQGHTLAWDT
IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSL
MWILYNLSRNPQVQQKLLKEIQSVLPENQRPREEDLRNMPYLKACLKESMRLTPGVPF
TTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFA
HLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPI
AFCQR

>48. CYP26A1 NM_000783 
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPL
PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
GDDRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEV
GSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT
RNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIE
HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKG
LLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
NVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKI
LLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI

>49. CYP26B1 AC007002
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQ
GSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNS
IGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQ
KLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRR
GIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIF
AAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLD
CVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDP
DRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRI
TLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV

>50. CYP26C1 AL358613.11 May 2, 2001 522 amino acids, 6 exons, 
MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQ (0)
GSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRK (0)
VLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGLRL
DEAQCATLARTFEQLVENLFSLPLDVPFSGLRK (0)
GIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELK (0)
ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPD
CGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELD (0)
GYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRLHYIPFGGGARSCLG
QELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL*

BE749195.1 199034 MARC 4BOV Bos taurus cDNA 5'. Length = 465
This is a Bovine EST that is the ortholog of human 26C1. 95% over 133aa
MLPWGLSCLSALGAVGTALLGAGLLLSLAQHLWTLRWTLSRDRASALPLPKGSMGWPFFGETLHWLVQ
GSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTVLLGEHRLVRSQWPQSAHILLGSHTLLGA

>51. CYP27A1 NM_000784
MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAP
GAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGP
QMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQA
LNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAIC
YILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWN
AIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLM
AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKE
TLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL
RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGEL
KSVARIVLVPNKKVGLQFLQRQC

>52. CYP27B1 NM_000785
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPS
TPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEG
PRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNN
VVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDT
ETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVE RREAEAA
MRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVD TVSNTLSWALYELS
RHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPD
KDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGF
GKRSCMGRRLAELELQMALAQ (0)
ILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR

>53. CYP27C1 AC027142 43% identical to 27A1 assembled gene
intron starting with QIH ending in VDT is from Celera's data
CRA_Gene|hCG42613 /len=10487.  This Celera sequence is still missing the C-terminal. Probable last exon is now found in AC027142.  AG Intron boundary is in the same location as CYP26B1.  Stop codon is one codon away from 26B1s stop codon.  Length is preserved from cys to intron. (n) = intron phase, 9 exons

  1  85452 MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQPAGARLPAGARAEDKGAGRPGSPPG 85634 61
 62  85635 GGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQ (0) 85748 99
100  39574 QKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISA (2) 39371 163
164  43984 EGEQWLKMRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSME (1) 43787 229 
230  41743 GVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC 41564 290
291  41563 RSWDGLFKFS 41534 300 (1)
301        QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDT (0) 354 (Celera sequence)
355 110201 TSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR (2) 110034 410
411 108566 LFPVLPGNGRVTQEDLVIGGYLIPKG (0) 108489 436
437 108006 TQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQ (0) 107794 504
505 102503 LLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK* 102619 542

>54. CYP39A1 AC008104 AL035670 note heme region exon corrected 1/18/02
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIK
YGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRT
ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVR
HLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLR 
NWSKSKKWFLELFEKNIPDIKACKSAKDNSM 
TLLQATLDIVETETSKENSPNYGLLLLWASLSNAVP
VAFWTLAYVLSHPDIHKAIMEGISSVFGKAG
KDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEIL
NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERW
KKANLEKHSFLDCFMAFGSGKFQCPARW
FALLEVQMCIILILYKYDCSLLDPLPKQ
SYLHLVGVPQPEGQCRIEYKQRI

>55. CYP46 NM_006668
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPS (phase 2)
FLLGHLPCFWKKDEVGGRVLQDVFLDW (phase 2)
AKKYGPVVRVNVFHKTSVIVTSPESVK (phase 0)
KFLMSTKYNKDSKMYRALQTVFGER (phase 2)
LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAK 
(phase 0) 
AAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK (phase 0)
FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK (phase 1)
AEEGAQDDEGLLDNFVTFFIA (phase 1)
GHETSANHLAFTVMELSRQPEIVAR (phase 2)
LQAEVDEVIGSKRYLDFEDLGRLQYLSQ (phase 0)
VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL (phase 0)
FSTYVMGRMDTYFEDPLTFNPDRFGPGAPK (phase 2)
PRFTYFPFSLGHRSCIGQQFAQ (phase 0)
MEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC

>56. CYP51 NM_000786
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTL
SLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVF
SFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLE
QKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHG
KEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQK
RRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLA
RDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMART
PQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGA
GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRS
K

>18P. CYP51P1 processed pseudogene U36926 5 in frame stops
    72 MAAAAGMMLLGLLQAGG*VLGQAMEEVAGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQL 251
   252 TAGAKSPPYIFSPVPFLGHAIAFGKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAA 431
   432 ALLFNSKNEVLNAEDVYSRLTTPVFG*GVAYDVPNPVFLEQKKTLKSGLNIAHFK*HVSI 611
   612 IEKETKEYFESWGESGEKNVFAALSELIILTASHYLHGKEIRSQHNEKVAQLYADLDGGF 791
   792 SHAAWLLPGWLPLPCFRRRDRAHQEIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR 971
   972 PLTDDEVAGMLTGLLLAEQHTSSTSA*MGFFLARDKTLQEKCYLEQKTVCGENLPPLTY  1148
  1149 DQLKDLNLLDRCIKETLRLRHPVMIMMRMARIPKTVAGYTIPPGHQVCVSPTVNQRLKDS 1328
  1329 WVEHLDFNPDRYL*DNPASREKFAYVPFGAGHHGCTGENFAYVQIKTIWSTMLRLYEFDL 1508
  1509 IDGYFPTVNYTTMIHTPENPVIHYK*RSK 1595 

>19P. CYP51P2 processed pseudogene U40053 one in frame stop and several frame shifts
  72 MAAAAGMMLLGLLQAG
 121 GSVLGQAMEEVTGGNLLSMLLIACTFTLSLVYLFRLAAGHLVQLPAGAKSPPYVFSPVP 297
 298 FPGHAIAFGKSPVEFLE 348
     NAYEKYGPVFSFTMVGKTFTYL 413
 414 LGSDAAALLFNSKNEDQNAEDVYSHLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNKAHF 593
 594 KQHVSL 611
 742 EKETKEYFQSWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFS 921
 922 HAAWLLPGWLPLPSFRCRDRAHWEIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRP 1101
1102 LTDDEVAGMLIGLLLAGQHSSSTTSAWMDFFLARDKTLQEKCYLEQKTVCGENLPPLTYD 1281
1282 QLKGLNLLDRCIKETLRLRPPIMIMMRMARTPQTVVGYTIPPGHQVCVSPTVNQRPKDSW 1461
1462 VERLDFNPDCYLQDNPASGEKFAYVPFGAGCHR*IGENFAYVQIKTIWSTMLRLYEFDLI 1641
1642 DGYFPIVNYTTMIHTPENPLIHYKRRSK 1725

AC010383 Homo sapiens chromosome 5 clone CTD-2071F4 41% to 27B1

1497 ILHDEALYPEPHLFKPERFLDEDGSLHAHARYPIEAFGYGRRICPGRHFAHDALWLAI 1324
1323 AHILAVFKIERALDEDGNESRGILRV 1246

gb|AC010383.2|AC010383 Homo sapiens chromosome 5 clone CTD-2071F4, WORKING DRAFT SEQUENCE, 4
            unordered pieces
          Length = 45527

Query: 74   MKHIPSWFPGAGWKRQALFWR-DVNREVRVRPFNLVKDQV 112
            +K+IPSWFPGAG+KR A  W+ DVN+   V P+   KD +
Sbjct: 2352 VKYIPSWFPGAGFKRIAAKWKTDVNKMFDV-PYAKFKDSM 2236

Query: 175  EVQKKGQAELDKVLNG-RLPEPNDGPNLPYISAMVKETLRWQL----------------- 219
            E Q+     LD VL   RLP   D   LP+I+A+  E LR+                   
Sbjct: 1885 EKQRAAHEALDCVLERKRLPGVEDRDALPHITALAYEVLRYVSSCF*LIFPRLTVRLGKM 1706

Query: 220  --------------------VLPLAVPHVAIEADEYNGYYIPKGTIVFGNSW 248
                                   LA+PH       Y GYYIP G+ +F NSW
Sbjct: 1705 ASCCPSMYVSKLPLCGWLLRVSLLAIPHRTTADSYYKGYYIPAGSTIFPNSW 1550

Query: 251  MHDPEVYKDPESYMPERFL-KDGKLDSSIRDPSTAVFGYGRRICPGRYFALNALYLMIAH 309
            +HD  +Y +P  + PERFL +DG L +  R P  A FGYGRRICPGR+FA +AL+L IAH
Sbjct: 1494 LHDEALYPEPHLFKPERFLDEDGSLHAHARYPIEA-FGYGRRICPGRHFAHDALWLAIAH 1318

Query: 310  TLAVFDIKPALDENDNEKEFKADVTGGMI 338
             LAVF I+ ALDE+ NE      V   M+
Sbjct: 1317 ILAVFKIERALDEDGNESRGILRVASSMVL 1228 end of contig at 1227

VKYIPSWFPGAGFKRIAAKWKTDVNKMFDVPYAKFKDSM
gap
EKQRAAHEALDCVLERKRLPGVEDRDALPHITALAYEVLRYVS (intron)
VSLLAIPHRTTADSYYKGYYIPAGSTIFPNSW (intron)
AILHDEALYPEPHLFKPERFLDEDGSLHAHARYPIEA
FGYGRRICPGRHFAHDALWLAIAHILAVFKIERALDEDGNESRGILRVASSMVL

resembles a plant EST 
gb|AW677250.1|AW677250 DG1_6_F07.g1_A002 Dark Grown 1 (DG1) Sorghum bicolor cDNA.
          Length = 501

 Score = 73.0 bits (176), Expect = 2e-12
 Identities = 35/77 (45%), Positives = 50/77 (64%), Gaps = 1/77 (1%)
 Frame = +1

Query: 1   ILHDEALYPEPHLFKPERFLDEDGSLHAHARYPIE-AFGYGRRICPGRHFAHDALWLAIA 59
           +LHD   YP P  F+PER++            P + AFGYGRRICPGR+ A D++++  A
Sbjct: 73  LLHDPETYPNPSAFEPERYIAPRNEPD-----PSDFAFGYGRRICPGRYLAEDSVFMTCA 237

Query: 60  HILAVFKIERALDEDGNE 77
            +LAVF + +A+DE+G E
Sbjct: 238 RLLAVFNMRKAVDENGKE 291

Also a fungal EST
emb|AJ271707.1|ABI271707 Agaricus bisporus partial mRNA for cytochrome P450 (>CYP gene)
          Length = 1098

 Score = 87.0 bits (212), Expect = 2e-16
 Identities = 45/76 (59%), Positives = 56/76 (73%), Gaps = 1/76 (1%)
 Frame = +1

Query: 2   LHDEALYPEPHLFKPERFLDEDGSLHAHARYPIEA-FGYGRRICPGRHFAHDALWLAIAH 60
           +HD  +Y +P  + PERFL +DG L +  R P  A FGYGRRICPGR+FA +AL+L IAH
Sbjct: 751 MHDPEVYKDPESYMPERFL-KDGKLDSSIRDPSTAVFGYGRRICPGRYFALNALYLMIAH 927

Query: 61  ILAVFKIERALDEDGNE 77
            LAVF I+ ALDE+ NE
Sbjct: 928 TLAVFDIKPALDENDNE 978

Genbank entry for this fungal gene
QLKSVRTFIRNVMESPDEFSEWIHFYTSSSIMEIIYGMKAKPED
PYVDNAKKAIEGFNEAAVPGKFLVETFPVMKHIPSWFPGAGWKRQALFWRDVNREVRV
RPFNLVKDQVNEGTATRSVCRTLIGNLPDSTAPDRIVKENIAIDTCAVSFIGAAETSH
SAARVFFMAMLMNPEVQKKGQAELDKVLNGRLPEPNDGPNLPYISAMVKETLRWQLVL
PLAVPHVAIEADEYNGYYIPKGTIVFGNSWTFMHDPEVYKDPESYMPERFLKDGKLDS
SIRDPSTAVFGYGRRICPGRYFALNALYLMIAHTLAVFDIKPALDENDNEKEFKADVT
GGMISQPVPFQCMIVPRSKAAADLIQNSDLME

AC004977 3A frag Homo sapiens clone DJ1152C17
106473 IIL*YGDVFLRNLRQKVEKGKPLTLR 106396

locus link entries for 2D family members on chr 22
1565
Hs
>CYP2D6
cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc., -metabolizing), polypeptide 6 
22q13.1

1566
Hs
>CYP2D7AP
cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc., -metabolising),
polypeptide 7a (pseudogene) 
22
AL021878
CDS complement(join(46168..46346,46445..46586,47042..47229,
47424..47565,47758..47934,48369..48529,48618..48770,
49134..49246,49290..49494,49300..49471,50174..50354))
/gene=">CYP2D7AP"
/note="dJ257I20.1 (cytochrome P450); cytochrome P450,
subfamily IID (debrisoquine, sparteine, etc.,
-metabolizing), polypeptide 8 (pseudogene)"

1567
Hs
>CYP2D7BP
cytochrome P450, subfamily II (debrisoquine,
sparteine, etc., -metabolising), polypeptide 7b
(pseudogene) 
22

1568
Hs
>CYP2D8P
cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc., -metabolizing),
polypeptide 8 (pseudogene) 
22q13.2-q13.31
AL021878
gene complement(55776..60892)
/gene=">CYP2D8P"
CDS complement(join(<55776..55954,55778..55955,
56053..56194,56645..56829,57034..57175,57362..57538,
57986..58148,58237..58389,58919..59090,60716..60892))
/gene=">CYP2D8P"
/note="dJ257I20.2 (cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc., -metabolising),
polypeptide 7a (pseudogene))"

1564
Hs
>CYP2D@
cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc., -metabolizing)cluster 
22q13

1569
Hs
>CYP2DL1
cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc.,
-metabolizing)-like 1 
22q11.2-qter

1570
Hs
>CYP2DP1
cytochrome P450, subfamily IID
(debrisoquine, sparteine, etc., -metabolizing)
pseudogene 1

gb|AC021892.3|AC021892 Homo sapiens chromosome 10 clone 53D03, *** SEQUENCING IN PROGRESS ***,
              28 unordered pieces
          Length = 168810
This is a plant P450 not human probably flavinoid hydroxylase
 Score =  485 bits (1235), Expect = e-135
 Identities = 258/410 (62%), Positives = 308/410 (74%), Gaps = 40/410 (9%)
 Frame = +2

Query: 101    PPNSGAEHMAYNYQDLVFAPYGPRWRMLRKICSVHLFSTKALDDFRHVRQDEVKTLTRAL 160
              PPNSGAEH+AYNYQDLVFAP     R LRK+C++HLFS KALDD R VR+ EV  + R L
Sbjct: 128576 PPNSGAEHVAYNYQDLVFAPTVALAR-LRKLCALHLFSAKALDDLRAVREGEVALMVRNL 128752

Query: 161    ASAGQKPVKLGQLLNVCTTNALARVMLGKRVFADGSGDVDPQAAEFKSMVVEMMVVAGVF 220
              A      V LGQ  NVC TN LAR  +G RVFA   G+    A EFK MVVE+M +AGVF
Sbjct: 128753 ARQQAASVALGQEANVCATNTLARATIGHRVFAVDGGE---GAREFKEMVVELMQLAGVF 128923

Query: 221    NIGDFIPQLNWLDIQGVAAKMKKLHARFDAFLTDILEEHK------GKIFGEM-KDLLST 273
              N+GDF+P L WLD QGV AKMK+LH R+D  +   + E K      G   GE   DLLS 
Sbjct: 128924 NVGDFVPALRWLDPQGVVAKMKRLHRRYDNMMNGFINERKAGAQPDGVAAGEHGNDLLSV 129103

Query: 274    LISLKNDDA--DNDGGKLTDTEIKALLL-------------------------------N 300
              L++   ++   D DG K+T+T+IKALLL                               N
Sbjct: 129104 LLARMQEEQKLDGDGEKITETDIKALLLVSS**PCLFRLSQHHFHVDMIFLLSFCGS**N 129283

Query: 301    LFVAGTDTSSSTVEWAIAELIRNPKILAQAQQEIDKVVGRDRLVGELDLAQLTYLEAIVK 360
              LF AGTDT+SSTVEWA+AELIR+P +L +AQ E+D VVGR RLV E DL +L YL A++K
Sbjct: 129284 LFTAGTDTTSSTVEWALAELIRHPDVLKEAQHELDTVVGRGRLVSESDLPRLPYLTAVIK 129463

Query: 361    ETFRLHPSTPLSLPRIASESCEINGYFIPKGSTLLLNVWAIARDPNAWADPLEFRPERFL 420
              ETFRLHPSTPLSLPR A+E CE++GY IPKG+TLL+NVWAIARDP  W DPL+++P RFL
Sbjct: 129464 ETFRLHPSTPLSLPREAAEECEVDGYRIPKGATLLVNVWAIARDPTQWPDPLQYQPSRFL 129643

Query: 421    PGGEKPKVDVRGNDFEVIPFGAGRRICAGMNLGIRMVQLMIATLIHAFNWDLVSGQLPEM 480
              PG     VDV+G DF +IPFGAGRRICAG++ G+RMV LM ATL+H F+W L +G  P+ 
Sbjct: 129644 PGRMHADVDVKGADFGLIPFGAGRRICAGLSWGLRMVTLMTATLVHGFDWTLANGATPDK 129823

Query: 481    LNMEEAYGLTLQRADPLVVHPRPRLEAQAY 510
              LNMEEAYGLTLQRA PL+V P PRL   AY
Sbjct: 129824 LNMEEAYGLTLQRAVPLMVQPVPRLLPSAY 129913