154    814
Cyp1a1     ---------- ---------- ---------M PSMYGLPAFV SATELLLAVT 
Cyp1a2     ---------- ---------- ---------- --MAFSQYIS LAPELLLATA 
Cyp1b1     ---------- ---------- --MATSLSAD SPQQLSSLST QQTTLLLLFS 
Cyp2a4     ---------- ---------- ---------- ----MLTSGL LLVAAVAFLS 
Cyp2a5     ---------- ---------- ---------- ----MLTSGL LLVAAVAFLS 
Cyp2a12    ---------- ---------- ---------- ----MLGSGL LLLAILAFLS 
Cyp2b9     ---------- ---------- ---------- ------MDPS VLLLLAVLLS 
Cyp2b10    ---------- ---------- ---------- ------MEPS VLLLLALLVG 
Cyp2b13    ---------- ---------- ---------- ------MDPS VLLLLAVLLS 
Cyp2b19    ---------- ---------- ---------- ------MEFS VLLLLALTTG 
Cyp2b23    ---------- ---------- ---------- ------MEPS VLLLLALLTG 
Cyp2c29    ---------- ---------- ---------- --------MD LVVFLALTLS 
Cyp2c37    ---------- ---------- ---------- --------MD PILVLVLTLS 
Cyp2c38    ---------- ---------- ---------- ---------D LVTFLVLTLS 
Cyp2c39    ---------- ---------- ---------- ---------D LVTFLVLTLS 
Cyp2c40    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c44    ---------- ---------- ---------- ----MELLGL PTLALLVLVM 
Cyp2c50    ---------- ---------- ---------- --------MD PILVLVFTLS 
Cyp2c54    ---------- ---------- ---------- --------MD PILVLVLTLS 
Cyp2c55    ---------- ---------- ---------- --------MD PVLVLVLTLS 
Cyp2c65    ---------- ---------- ---------- --------MV LGVFLGLLLT 
Cyp2c66    ---------- ---------- ---------- --------MV LGVFLGLLLT 
Cyp2c67    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c68    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c69    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c70    ---------- ---------- ---------- -----SESMA LFIFLGIWLS 
Cyp2d9     ---------- ---------- ---------- ------MELL TGTDLWPVA- 
Cyp2d10    ---------- ---------- ---------- ------MELL TGAGLWSVA- 
Cyp2d11    ---------- ---------- ---------- ------MELL TGAGLWSVA- 
Cyp2d12    ---------- ---------- ---------- ------MELL TGTDLWSVA- 
Cyp2d13    ---------- ---------- ---------- ------MELL TGTGLWPVA- 
Cyp2d22    ---------- ---------- ---------- ------MRLP TGAELWPIA- 
Cyp2d26    ---------- ---------- ---------- ------MGLL VGDDLWAVV- 
Cyp2e1     ---------- ---------- ---------- -----MAVLG ITVALLVWIA 
Cyp2f2     ---------- ---------- ---------- -------MDG VSTAILLLLL 
Cyp2g1     ---------- ---------- ---------- ----MMLGGA FSIFMALCLS 
Cyp2j5     ---------- ---------- ---------- ---MIMFLSS LVTTFWEALH 
Cyp2j6     ---------- ---------- ---------- ---MLAATGS LLATIWAALH 
Cyp2j7     ---------- ---------- ---------- ---MLSTVGS LVARIWSAIH 
Cyp2j8     ---------- ---------- ---------- ---MFATIGC LVSNICSEIH 
Cyp2j9     ---------- ---------- ---------- ---MLAAAGS LVAAIWAALH 
Cyp2j13    ---------- ---------- ---------- ---MLEAADS LAAAFWAALH 
Cyp2j12    ---------- ---------- ---------- ---MLATEDT FETAIWALLH 
cyp2j11    ---------- ---------- ---------- ---MLAIATC LVANICSATH 
Cyp2r1     ---------- ---------- ---------- -------MLE LPGARACAGA 
Cyp2s1     ---------- ---------- ---------- ------MEAA STWALLLALL 
Cyp2t4     ---------- ---------- ---------- --------MV TCLALLLLLL 
Cyp2U1     ---------- ---------- ---------- ---MSSLGDQ RPAAGEQPG- 
Cyp2w1     ---------- ---------- ---------- --MALLLLGV WGILLLLGLW 
CYP2W1h    ---------- ---------- ---------- --MALLLL-- -LFLGLLGLW 
Cyp3a11    ---------- ---------- --------MD LVSALSLETW VLLAISLVLL 
Cyp3a13    ---------- ---------- --------MD LIPNFSMETW MLLATSLVLL 
Cyp3a16    ---------- ---------- --------MN LFSALSLDTL VLLAIILVLL 
Cyp3a25    ---------- ---------- --------ME LIPNLSIETW VLLVTSLVLF 
Cyp3a57    ---------- ---------- --------ME LIPNLSIQTW VLLVTSLVFF 
Cyp3a41    ---------- ---------- --------MN LFSALSLDTW VLLAIILVLL 
Cyp3a44    ---------- ---------- --------MN LFSALSLDTL VLLAIILVLL 
Cyp4a10    ---------- --------MS VSALSPTRFA DSLSGFLQVA SVLGLLLLLV 
Cyp4a12    ---------- --------MS ASALSSIRFP GSISEYLQVA SVLSLLLLLF 
Cyp4a14    ---------- --------MG FFLFSPTRYL DGISGFFQWA FLLSLFLVLF 
Cyp4a30    ---------- --------MS IFELSHITNV FGIFGLLQVV SLLGLLLLLL 
Cyp4a29    ---------- --------MS ISALSPIRFL ECVSGFLQVI FLIGLLLLLF 
Cyp4b1     ---------- ---------- ---MALSFLS PSLSRLGLWA SVVILMVTVL 
Cyp4f13    ---------- --------ML QLCLSWLGMG SLTASPWHLL LLGGASWILA 
Cyp4f14    ---------- --------MS QLSLSWLGLG PEVAFPWKTL LLLGASWILA 
Cyp4f15    ---------- ---MGFFRMP QLDLSWLGLR LEASSPWLLL LLIGASWLLA 
Cyp4f16    ---------- --------ML RLSVSGLDLG SVVTSSWHLL LLGVASWILA 
Cyp4f17    ---------- --------ML QLGLSWLGLG PGAAFPWQLL QLVGASLFLA 
Cyp4f18    ---------- --------MS QLSLSWMGLG HTAASPWLLL LLAGASCLLA 
Cyp4f37    ---------- --------ML RLSVSGLDLG SVVTLSWHLL LLGAASWILA 
Cyp4f39    ---------- MLPLTDYLLQ LLGLEKTAFR VYVVSALLLL VLFFFFRLLV 
Cyp4f40    ---------- --------MR YLDLSWLGLG PMSASPWLLF FLVGISWFLA 
Cyp4v3     ---------- --------ML WLWLGLSGQK LLLWGAASAV SLAGATILIS 
Cyp4x1     ---------- ---------- ---MEASWLE TRWARPLHLA LVFCLALVLM 
Cyp5a1     ---------- ---------- --MEVLGLLK FEVSGTIVTV TLLVALLALL 
Cyp7a1     ---------- ---------- ---------- ---MMSISLI WGIAVVVSCC 
Cyp7b1     ---------- ---------- ---MQGATTL DAASPGPLAL LGLLFAATLL 
Cyp8a1     ---------- ---------- ---------- ----MSWAAL LGLLAVLLL- 
Cyp8b1     ---------- ---------- ---------- ---MTLWCTV LGALLTVVG- 
Cyp11a1    ---------- ---------- -----MLAKG LSLRSVLVKG CQPFLSPTWQ 
Cyp11b1    ---------- ---------- ---------- ----MALRVT TDVWLARPWQ 
Cyp11b2    ---------- ---------- ---------- ----MALRVT ADVWLARPWQ 
Cyp17      ---------- ---------- ---------- ---MWELVGL LLLILAYFFW 
Cyp19      ---------- ---------- ---------- --MFLEMLNP MQYNVTIMVP 
Cyp20      ---------- ---------- -------MLD FAIFAVTFLL ALVGAVLYLY 
Cyp21      ---------- ---------- ---------- -------MLL PGLLLLLLLL 
Cyp24      ---------- ---------- ---------- ----MSCPID KRRPLIAFLR 
Cyp26a1    ---------- ---------- ---MGLPALL ASALCTFVLP LLLFLAALKL 
Cyp26b1    ---------- --------ML FEGLELVSAL ATLAACLVSV TLLLAVSQQL 
Cyp26c1    ---------- --------MI SWGLSCLSVL GAAGTTLLCA GLLLGLAQQL 
Cyp27a1    ---------- ---------- ---------- ------MAAW SRTRLRWTLL 
Cyp27b1    ---------- ---------- --------LE ADSPNTDMTQ AVKLASRVFH 
Cyp39      ---------- ---------- ---------- ----MGIMEL FSPIAIAVLG 
Cyp46      ---------- ---------- ------MSPG LLLLGSAVLL AFGLCCTFVH 
Cyp51      ---------- ---------- ---MEQVTGG NLLSTLLIAC AFTLSLVYLF 
CYP1A1h    ---------- ---------- ---------- ---MLFPISM SATEFLLASV 
CYP1A2h    ---------- ---------- ---------- -MALSQSVPF SATELLLASA 
CYP1B1h    ---------- ---------- --MGTSLSPN DPWPLNPLSI QQTTLLLLLS 
CYP2A6     ---------- ---------- ---------- ----MLASGM LLVALLVCLT 
CYP2A7     ---------- ---------- ---------- ----MLASGL LLVALLACLT 
CYP2A13    ---------- ---------- ---------- ----MLASGL LLVTLLACLT 
CYP2B6     ---------- ---------- ---------- ------MELS VLLFLALLTG 
CYP2C8     ---------- ---------- ---------- --------ME PFVVLVLCLS 
CYP2C9     ---------- ---------- ---------- --------MD SLVVLVLCLS 
CYP2C18    ---------- ---------- ---------- --------MD PAVALVLCLS 
CYP2C19    ---------- ---------- ---------- --------MD PFVVLVLCLS 
CYP2D6     ---------- ---------- ---------- ---------M GLEALVPLA- 
CYP2E1h    ---------- ---------- ---------- -----MSALG VTVALLVWAA 
CYP2F1     ---------- ---------- ---------- -------MDS ISTAILLLLL 
CYP2G2P    ---------- ---------- ---------- ----MEMGGA VTIFLALCLS 
CYP2J2     ---------- ---------- ---------- ---MLAAMGS LAAALWAVVH 
CYP2R1h    ---------- ---------- ---------- -------MWK LWRAEEGAAA 
CYP2S1h    ---------- ---------- ---------- ------MEAT GTWALLLALA 
CYP2T2P    ---------- ---------- ---------- ---------- ---------- 
CYP2U1h    ---------- ---------- ---------- ---MSSPGPS QPPAEDPPWP 
CYP3A4     ---------- ---------- --------MA VIPDLAMETW LLLAVSLVLL 
CYP3A5     ---------- ---------- --------MD LIPNLAVETW LLLAVSLVLL 
CYP3A7     ---------- ---------- --------MD LIPNLAVETW LLLAVSLILL 
CYP3A43    ---------- ---------- --------MD LIPNFAMETW VLVATSLVLL 
CYP4A11    ---------- --------MS VSVLSPSRLL GDVSGILQAA SLLILLLLLI 
CYP4A22    ---------- --------MS VSVLSPSRRL GGVSGILQVT SLLILLLLLI 
CYP4B1h    ---------- ---------- ---MVPSFLS LSFSSLGLWA SGLILVLGFL 
CYP4F2     ---------- --------MS QLSLSWLGLW PVAASPWLLL LLVGASWLLA 
CYP4F3     ---------- --------MP QLSLSSLGLW PMAASPWLLL LLVGASWLLA 
CYP4F8     ---------- --------MS LLSLSWLGLR PVAASPWLLL LVVGASWLLA 
CYP4F11    ---------- --------MP QLSLSWLGLG PVAASPWLLL LLVGGSWLLA 
CYP4F12    ---------- --------MS LLSLPWLGLR PVAMSPWLLL LLVVGSWLLA 
CYP4F22    ---------- MLPITDRLLH LLGLEKTAFR IYAVSTLLLF LLFFLFRLLL 
CYP4F23P   ---------- --------MS LLSLSWLGLG PVAASPWLLL LLVGASWLLA 
CYP4V2     ---------- --------MA GLWLGLVWQK LLLWGAASAV SLAGASLVLS 
CYP4X1h    ---------- ---------- ---MEFSWLE TRWARPFYLA FVFCLALGLL 
CYP4Z1     ---------- ---------- ---MEPSWLQ ELMAHPFLLL ILLCMSLLLF 
CYP5A1h    ---------- ---------- -MMEALGFLK LEVNGPMVTV ALSVALLALL 
CYP7A1h    ---------- ---------- ---------- ---MMTTSLI WGIAIAACCC 
CYP7B1h    ---------- ---------- -MAGEVSAAT GRFSLERLGL PGLALAAALL 
CYP8A1h    ---------- ---------- ---------- ----MAWAAL LGLLVALLL- 
CYP8B1h    ---------- ---------- ---------- ---MVLWGPV LGALLVVIAG 
CYP11A1h   ---------- ---------- -----MLAKG LPPRSVLVKG YQTFLSAPRE 
CYP11B1h   ---------- ---------- ---------- ----MALRAK AEVCMAVPWL 
CYP11B2h   ---------- ---------- ---------- ----MALRAK AEVCVAAPWL 
CYP17h     ---------- ---------- ---------- ---MWELVAL LLLTLAYLFW 
CYP19h     ---------- ---------- ---------- --MVLEMLNP IHYNITSIVP 
CYP20h     ---------- ---------- -------MLD FAIFAVTFLL ALVGAVLYLY 
CYP21A2h   ---------- ---------- ---------- -------MLL LGLLLLLPLL 
CYP24h     ---------- ---------- ---------- ----MSSPIS KSRSLAAFLQ 
CYP26A1h   ---------- ---------- ---MGLPALL ASALCTFVLP LLLFLAAIKL 
CYP26B1h   ---------- --------ML FEGLDLVSAL ATLAACLVSV TLLLAVSQQL 
CYP26C1h   ---------- --------MF PWGLSCLSVL GAAGTALLCA GLLLSLAQHL 
CYP27A1h   ---------- ---------- ---------- ------MAAL GCARLRWALR 
CYP27B1h   ---------- ---------- ---------- -------MTQ TLKYASRVFH 
CYP27C1h   ---------- ---------- ---------- ------MQTS AMALLARILR 
CYP39A1h   ---------- ---------- ---------- -------MEL ISPTVIIILG 
CYP46h     ---------- ---------- ------MSPG LLLLGSAVLL AFGLCCTFVH 
CYP51h     MAAAAGMLLL GLLQAGGSVL GQAMEKVTGG NLLSMLLIAC AFTLSLVYLI 

Cyp1a1                ---------- ---------- VFCLGFWVVR A--------- ---------- 
Cyp1a2                ---------- ---------- IFCLVFWMVR A--------- ---------- 
Cyp1b1                ---------- ---------- VLAAVHLGQW L--------- ---------- 
Cyp2a4                ---------- ---------- VLVLMSVW-- ---------- ---------- 
Cyp2a5                ---------- ---------- VLVLMSVW-- ---------- ---------- 
Cyp2a12               ---------- ---------- VMVLVSVW-- ---------- ---------- 
Cyp2b9                ---------- ---------- LFLLLVR--- ---------- ---------- 
Cyp2b10               ---------- ---------- FLLLLAR--- ---------- ---------- 
Cyp2b13               ---------- ---------- LFLLLVR--- ---------- ---------- 
Cyp2b19               ---------- ---------- FLIFLVSQ-- ---------- ---------- 
Cyp2b23               ---------- ---------- FLLLLIR--- ---------- ---------- 
Cyp2c29               ---------- ---------- CLILLSLW-- ---------- ---------- 
Cyp2c37               ---------- ---------- CLFLLSLW-- ---------- ---------- 
Cyp2c38               ---------- ---------- SLILLSLW-- ---------- ---------- 
Cyp2c39               ---------- ---------- SLILLSLW-- ---------- ---------- 
Cyp2c40               ---------- ---------- FLLVLSLW-- ---------- ---------- 
Cyp2c44               ---------- ---------- SLSLLSVW-- ---------- ---------- 
Cyp2c50               ---------- ---------- CLFLLSLW-- ---------- ---------- 
Cyp2c54               ---------- ---------- CLFLLSLW-- ---------- ---------- 
Cyp2c55               ---------- ---------- CLLLLSLW-- ---------- ---------- 
Cyp2c65               ---------- ---------- CLLLLSLW-- ---------- ---------- 
Cyp2c66               ---------- ---------- CLLLLSLW-- ---------- ---------- 
Cyp2c67               ---------- ---------- FLLVLSLW-- ---------- ---------- 
Cyp2c68               ---------- ---------- FLLLLSLW-- ---------- ---------- 
Cyp2c69               ---------- ---------- FMLLLSLW-- ---------- ---------- 
Cyp2c70               ---------- ---------- CFLFLFLW-- ---------- ---------- 
Cyp2d9                ---------- --------IF TVIFILLVDL T--------- ---------- 
Cyp2d10               ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d11               ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d12               ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d13               ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d22               ---------- --------IF TVIFLILVNL M--------- ---------- 
Cyp2d26               ---------- --------IF TAIFLLLVDL V--------- ---------- 
Cyp2e1                ---------- ---------- TLLLVSIW-- ---------- ---------- 
Cyp2f2                ---------- ---------- AVISLSLT-- ---------- ---------- 
Cyp2g1                ---------- ---------- CLLILIAW-- ---------- ---------- 
Cyp2j5                LK-------- --------TL VLAVVTFLFL I--------- ---------- 
Cyp2j6                PR-------- --------TL LVAAVTFLLL A--------- ---------- 
Cyp2j7                LW-------- --------TL LLTLLVFRLL A--------- ---------- 
Cyp2j8                LW-------- --------TL LLAALTLLLL V--------- ---------- 
Cyp2j9                LR-------- --------IL LLSAVTFLFL A--------- ---------- 
Cyp2j13               LR-------- --------TL LLAAVTFLFL A--------- ---------- 
Cyp2j12               FK-------- --------TL VLAAVTFMLL A--------- ---------- 
cyp2j11               LW-------- --------TL LLTLLTLLLL A--------- ---------- 
Cyp2r1                LA-------- --------GA LLLLLFVLVV R--------- ---------- 
Cyp2s1                ---------- ---------- LLLLLLS--- L--------- ---------- 
Cyp2t4                ---------- ---------- ILMLLLWWGG V--------- ---------- 
Cyp2U1                --------AR LHVRATGGAL LLCLLAVLLG W--------- ---------- 
Cyp2w1                ---------- ---------- GLLQGCTR-- ---------- ---------- 
CYP2W1h               ---------- ---------- GLLCACAQ-- ---------- ---------- 
Cyp3a11               Y--------- ---------- RYGTRKHEL- ---------- ---------- 
Cyp3a13               Y--------- ---------- LYGTHSHGI- ---------- ---------- 
Cyp3a16               Y--------- ---------- RYGTYTHGL- ---------- ---------- 
Cyp3a25               Y--------- ---------- IYGTYSHGL- ---------- ---------- 
Cyp3a57               Y--------- ---------- IYGTYSHGL- ---------- ---------- 
Cyp3a41               Y--------- ---------- RYGTRTHGL- ---------- ---------- 
Cyp3a44               Y--------- ---------- RYGTRTHGL- ---------- ---------- 
Cyp4a10               K--------- ---------- AVQFYLHRQ- ---------- ---------- 
Cyp4a12               K--------- ---------- TAQLYLHRQ- ---------- ---------- 
Cyp4a14               K--------- ---------- AVQFYLRRQ- ---------- ---------- 
Cyp4a30               K--------- ---------- SAQYYLHRQ- ---------- ---------- 
Cyp4a29               K--------- ---------- AAQHYLRRQ- ---------- ---------- 
Cyp4b1                K--------- ---------- LLSLLFRRQ- ---------- ---------- 
Cyp4f13               R--------- ---------- ILAWIYAFY- ---------- ---------- 
Cyp4f14               R--------- ---------- ILIQIYAAY- ---------- ---------- 
Cyp4f15               R--------- ---------- VLTQTYIFY- ---------- ---------- 
Cyp4f16               R--------- ---------- ILAWTYSFY- ---------- ---------- 
Cyp4f17               R--------- ---------- ILTWICAFY- ---------- ---------- 
Cyp4f18               Y--------- ---------- ILTQIYGVF- ---------- ---------- 
Cyp4f37               R--------- ---------- ILAWTYSFC- ---------- ---------- 
Cyp4f39               R--------- ---------- AFKLFSDFR- ---------- ---------- 
Cyp4f40               R--------- ---------- FLTQLYTLY- ---------- ---------- 
Cyp4v3                ---------- ---------- IFPMLVSYA- ---------- ---------- 
Cyp4x1                Q--------- ---------- AMKLYLRRQ- ---------- ---------- 
Cyp5a1                K--------- ---------- WYSMSAFSR- ---------- ---------- 
Cyp7a1                ---------- ---------- IWFIIGIRR- ---------- ---------- 
Cyp7b1                ---------- ---------- LSALFLLTRR ---------- ---------- 
Cyp8a1                ---------- ---------- LLLLLSRRR- ---------- ---------- 
Cyp8b1                ---------- ---------- CLCLSLLLR- ---------- ---------- 
Cyp11a1               GP-------- --------VL STGKGAGTST S--------- ---------- 
Cyp11b1               CLHR------ --------TR ALGTTATLAP K--------- ---------- 
Cyp11b2               CLHR------ --------TR ALGTTATLAP K--------- ---------- 
Cyp17                 P--------- ---------- ---------- ---------- ---------- 
Cyp19                 ---------- -------ETV TVSAMPLLLI MG-------- ---------- 
Cyp20                 P--------- ---------- ASRQASGIP- ---------- ---------- 
Cyp21                 A--------- ---------- ---------- ---------- ---------- 
Cyp24                 R--------- --------LR DLGQPPRSVT SKAHVKRAPK E--------- 
Cyp26a1               ---------- ---------- WDLYCVSSRD ---------- ---------- 
Cyp26b1               ---------- ---------- WQLRWAATRD ---------- ---------- 
Cyp26c1               ---------- ---------- WTLRWTLSRD ---------- ---------- 
Cyp27a1               DPRVVG---- -RGLCPQGAR AKATIPAALQ AQESTEGPGT G--------- 
Cyp27b1               R--------- --------IH LPLQLDASLG S--------- ---------- 
Cyp39                 ---------- ---------- SCVLFLFSR- ---------- ---------- 
Cyp46                 R--------- ---------- ARSRYEHIP- ---------- ---------- 
Cyp51                 ---------- ---------- RLAVGHMVQL ---------- ---------- 
CYP1A1h               ---------- ---------- IFCLVFWVIR A--------- ---------- 
CYP1A2h               ---------- ---------- IFCLVFWVLK G--------- ---------- 
CYP1B1h               ---------- ---------- VLATVHVGQR L--------- ---------- 
CYP2A6                ---------- ---------- VMVLMSVW-- ---------- ---------- 
CYP2A7                ---------- ---------- VMVLMSVW-- ---------- ---------- 
CYP2A13               ---------- ---------- VMVLMSVW-- ---------- ---------- 
CYP2B6                ---------- ---------- LLLLLVQ--- ---------- ---------- 
CYP2C8                ---------- ---------- FMLLFSLW-- ---------- ---------- 
CYP2C9                ---------- ---------- CLLLLSLW-- ---------- ---------- 
CYP2C18               ---------- ---------- CLFLLSLW-- ---------- ---------- 
CYP2C19               ---------- ---------- CLLLLSIW-- ---------- ---------- 
CYP2D6                ---------- --------VI VAIFLLLVDL M--------- ---------- 
CYP2E1h               ---------- ---------- FLLLVSMW-- ---------- ---------- 
CYP2F1                ---------- ---------- ALVCLLLT-- ---------- ---------- 
CYP2G2P               ---------- ---------- CLLILIAW-- ---------- ---------- 
CYP2J2                PR-------- --------TL LLGTVAFLLA A--------- ---------- 
CYP2R1h               LG-------- --------GA LFLLLFALGV R--------- ---------- 
CYP2S1h               ---------- ---------- LLLLLT---- L--------- ---------- 
CYP2T2P               ---------- ---------- ---------- ---------- ---------- 
CYP2U1h               ARLLRAPLGL LRLDPSGGAL LLCGLVALLG W--------- ---------- 
CYP3A4                Y--------- ---------- LYGTHSHGL- ---------- ---------- 
CYP3A5                Y--------- ---------- LYGTRTHGL- ---------- ---------- 
CYP3A7                Y--------- ---------- LYGTRTHGL- ---------- ---------- 
CYP3A43               Y--------- ---------- IYGTHSHKL- ---------- ---------- 
CYP4A11               K--------- ---------- AVQLYLHRQ- ---------- ---------- 
CYP4A22               K--------- ---------- AAQLYLHRQ- ---------- ---------- 
CYP4B1h               K--------- ---------- LIHLLLRRR- ---------- ---------- 
CYP4F2                H--------- ---------- VLAWTYAFY- ---------- ---------- 
CYP4F3                R--------- ---------- ILAWTYTFY- ---------- ---------- 
CYP4F8                R--------- ---------- ILAWTYAFY- ---------- ---------- 
CYP4F11               R--------- ---------- VLAWTYTFY- ---------- ---------- 
CYP4F12               R--------- ---------- ILAWTYAFY- ---------- ---------- 
CYP4F22               R--------- ---------- FLRLCRSFY- ---------- ---------- 
CYP4F23P              R--------- ---------- VLAWTYAFY- ---------- ---------- 
CYP4V2                ---------- ---------- LLQRVASYA- ---------- ---------- 
CYP4X1h               Q--------- ---------- AIKLYLRRQ- ---------- ---------- 
CYP4Z1                Q--------- ---------- VIRLYQRRR- ---------- ---------- 
CYP5A1h               K--------- ---------- WYSTSAFSR- ---------- ---------- 
CYP7A1h               ---------- ---------- LWLILGIRR- ---------- ---------- 
CYP7B1h               ---------- ---------- LLALCLLVRR ---------- ---------- 
CYP8A1h               ---------- ---------- LLLLS-RRR- ---------- ---------- 
CYP8B1h               ---------- ---------- YLCLPGMLR- ---------- ---------- 
CYP11A1h              GLGRL----- --------RV PTGEGAGIST R--------- ---------- 
CYP11B1h              SLQR------ --------AQ ALGTRAARVP R--------- ---------- 
CYP11B2h              SLQR------ --------AR ALGTRAARAP R--------- ---------- 
CYP17h                P--------- ---------- ---------- ---------- ---------- 
CYP19h                ---------- -------EAM PAATMPVLLL TG-------- ---------- 
CYP20h                P--------- ---------- ASRQAAGIP- ---------- ---------- 
CYP21A2h              A--------- ---------- ---------- ---------- ---------- 
CYP24h                Q--------- --------LR SPRQPPRLVT STAYTSPQPR E--------- 
CYP26A1h              ---------- ---------- WDLYCVSGRD ---------- ---------- 
CYP26B1h              ---------- ---------- WQLRWAATRD ---------- ---------- 
CYP26C1h              ---------- ---------- WTLRWMLSRD ---------- ---------- 
CYP27A1h              G--AG----- -RGLCPHGAR AKAAIPAALP SDKATGAPGA G--------- 
CYP27B1h              R--------- --------VR WAPELGASLG Y--------- ---------- 
CYP27C1h              AG-------- --------LR PAPERGGLLG GGAPRRPQPA GARLPAGARA 
CYP39A1h              ---------- ---------- CLALFLLLQ- ---------- ---------- 
CYP46h                R--------- ---------- ARSRYEHIP- ---------- ---------- 
CYP51h                ---------- ---------- RLAAGHLVQL ---------- ---------- 

Cyp1a1                ---------- ----TRTWVP KGLKTPPGPW GLPFIGHMLT VGKNPH---- 
Cyp1a2                ---------- ----SRTQVP KGLKNPPGPW GLPFIGHMLT VGKNPH---- 
Cyp1b1                ---------- ----LRQWQR KPWSSPPGPF PWPLIGNAAA VGQASH---- 
Cyp2a4                ---------- ------KQRK LSGKLPPGPT PLPFVGNFLQ LNTEQMY--- 
Cyp2a5                ---------- ------KQRK LSGKLPPGPT PLPFIGNFLQ LNTEQMY--- 
Cyp2a12               ---------- ------QQKI R-GKLPPGPI PLPFIGNYLQ LNRKDVY--- 
Cyp2b9                ---------- ------GHAK IHGHLPPGPH PLPLLGNLLQ MDRGGLL--- 
Cyp2b10               ---------- ------GHPK SRGNFPPGPR PLPLLGNLLQ MDRGGLL--- 
Cyp2b13               ---------- ------GHAK IHGHLPPGPR PLPLLGNLLQ MDRGGLL--- 
Cyp2b19               ---------- ------SQPK THGHFPPGPR PLPFLGNLLQ MDRRGLL--- 
Cyp2b23               ---------- ------GQPK AYSRLPPGPR PLPFLGNLLQ MDRGGLL--- 
Cyp2c29               ---------- ------RQSS GRGKLPPGPT PLPIIGNFLQ IDVKNIS--- 
Cyp2c37               ---------- ------RQSS ERGKLPPGPT PLPIIGNILQ IDVKDIC--- 
Cyp2c38               ---------- ------RQRS RRGRLPPGPT PFPIIGNFLQ IDVKNFN--- 
Cyp2c39               ---------- ------RQSC GRGSLPPGPT PFPIIGNFLQ IDMKNFS--- 
Cyp2c40               ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c44               ---------- ------TKMR TGGRLPPGPT PLPIIGNILQ LDLKDIP--- 
Cyp2c50               ---------- ------RQSS ERGKLPPGPT PLPIIGNILQ INVKDIC--- 
Cyp2c54               ---------- ------RQSY ERGKLPPGPT PLPIIGNILQ IDVKDIC--- 
Cyp2c55               ---------- ------RQNS GRGKLPPGPT PFPIIGNILQ IDIKNIS--- 
Cyp2c65               ---------- ------RQNS QRRNLPPGPT PLPIIGNILQ LDLKDIS--- 
Cyp2c66               ---------- ------KQNS QRRNLPPGPT PLPIIGNILQ LDLKDIS--- 
Cyp2c67               ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c68               ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c69               ---------- ------RQRS ARRNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c70               ---------- ------NQHR GRGKLPPGPT PLPIVGNILQ VYVKNIS--- 
Cyp2d9                ---------- ----HQR-QR WTSRYPPGPV PWPVLGNLLQ VDLGNMP--- 
Cyp2d10               ---------- ----HRH-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d11               ---------- ----HRH-QH WTSRCPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d12               ---------- ----YRR-QS WTSCYPPGPV PWPVLGNLLQ VDLNNMP--- 
Cyp2d13               ---------- ----HRR-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d22               ---------- ----HWR-QR WTAHYPPGPM PWPVLGNLLH MDFQNMP--- 
Cyp2d26               ---------- ----HRR-QR WTACYPPGPV PFPGLGNLLQ VDFENIP--- 
Cyp2e1                ---------- ------KQIY RSWNLPPGPF PIPFFGNIFQ LDLKDIP--- 
Cyp2f2                ---------- ------FSSR GKGQLPPGPK PLPILGNLLQ LRSQDLL--- 
Cyp2g1                ---------- ------KRTS KGGKLPPGPT PIPFLGNFLQ VRTDATF--- 
Cyp2j5                ---------- ----NILRSR HPKNYPPGPW RLPFVGNFFQ IDTKQT---- 
Cyp2j6                ---------- ----DYFKNR RPKNYPPGPW GLPFVGNIFQ LDFGQP---- 
Cyp2j7                ---------- ----DYLKNR RPKNYPPGPW RLPFVGNLFQ FDLDVSQ--- 
Cyp2j8                ---------- ----DYIKNR HPKNYPPGPW RLPFVGNLFQ FDLDVSH--- 
Cyp2j9                ---------- ----DFLKNR RPKNYPPWPM RLPFVGCLFH LDPKQP---- 
Cyp2j13               ---------- ----DYLKSR RPKNYPPRPP RLPFVGNSFQ MDLTQS---- 
Cyp2j12               ---------- ----HYLKTQ RPKNYPPGPW RLPFVGNLFQ LDLEQP---- 
cyp2j11               ---------- ----DYLKNR RPKNYPPGPR RLPFVGNLFQ FDLDVSR--- 
Cyp2r1                ---------- ----QLLRQR RPAGFPPGPP RLPFVGNICS LALSADL--- 
Cyp2s1                ---------- ----TLFRTP ARGYLPPGPT PLPLLGNLLQ LRPGALY--- 
Cyp2t4                ---------- ----VRRQAQ MQKDLPPGPA PLPLLGNLLQ LQSGDLD--- 
Cyp2U1                ---------- ----VWLRRQ RACGIPPGPK PRPLVGNFGH LLVPRFLRPQ 
Cyp2w1                ---------- -------SPS LAPRWPPGPR PLPFLGNLHL LGVTQQD--- 
CYP2W1h               ---------- -------DPS PAARWPPGPR PLPLVGNLHL LRLSQQD--- 
Cyp3a11               ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYKG------ 
Cyp3a13               ---------- ---------- FKKLGIPGPK PLPFLGTILA YQKG------ 
Cyp3a16               ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYKG------ 
Cyp3a25               ---------- ---------- FKKLGIPGPK PLPLLGTIFN YYDG------ 
Cyp3a57               ---------- ---------- FKKLGIPGPK PLPLFGNIIN YLDG------ 
Cyp3a41               ---------- ---------- FKKQGIPGPT PLPFLGTVLN YYKG------ 
Cyp3a44               ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYTG------ 
Cyp4a10               ---------- ------WLLK AFQQFPSPPF -HWFFGHEQF KG---DH--- 
Cyp4a12               ---------- ------WLLS STQQFPSPPS -HWLFGHKIL K----DQ--- 
Cyp4a14               ---------- ------WLLK TLQHFPCMPS -HWLWGHHLK D-----K--- 
Cyp4a30               ---------- ------WLIK SLQQFPPAPP -PQWLFGNXX FPK--DQ--- 
Cyp4a29               ---------- ------WLLR ALYQFPSPPS -HWLFGHQFK VD----E--- 
Cyp4b1                ---------- ------KLAR ALDSFPGPPK -HWLFGHALE IQK--TG--- 
Cyp4f13               ---------- ------DNCS RLRCFPQPPK PSWFWGHLAL MKNN-EE--- 
Cyp4f14               ---------- ------RNYR HLHGFPQPPK RNWLMGHVGM VTPT-EQ--- 
Cyp4f15               ---------- ------RTYH HLCDFPQPPK WNWFLGHLGM ITPT-EH--- 
Cyp4f16               ---------- ------ENCS RLSCFPQPPK KNWFSGHLGM IQSN-EE--- 
Cyp4f17               ---------- ------DNYC RLRCFPEPPS RHWFWGHMSM VKNN-EE--- 
Cyp4f18               ---------- ------ENSL RLRCFPQPPK RNWILGHLGL IQSS-EE--- 
Cyp4f37               ---------- ------ENCS RLRCFPQPPK RNWFLGHLGM IEHN-EE--- 
Cyp4f39               ---------- ------ITCR KLSCFPEPPG RHWLLGHMSM VSPN-EK--- 
Cyp4f40               ---------- ------AKCQ RLCGFPQPPK KNWFWGHLGM VSPT-EE--- 
Cyp4v3                ---------- ------RKWQ QMRSIPSVAR AYPLVGHALY MKPNNAE--- 
Cyp4x1                ---------- ------RLLR DLSPFPGPPA -HWLLGHQKF LQ---ED--- 
Cyp5a1                ---------- ------LEKL GIRHPKPSP- ---FVGNLMF FRQG------ 
Cyp7a1                ---------- ---------R KVGEPPLDNG LIPYLGCALK FGSNPLE--- 
Cyp7b1                ---------- --------TR RPREPPLIKG WLPYLGMALK FFKDPLT--- 
Cyp8a1                ---------- --------AR RPGEPPLDLG SIPWLGHALE FGRDAAS--- 
Cyp8b1                ---------- --------HR RPWEPPLDKG FVPWLGHSMA FRKNMFE--- 
Cyp11a1               ---------- ------SPRS FNEIPSPGDN GWLNLYHFWR ESGTQKIH-- 
Cyp11b1               ---------- ------TLQP FEAIPQYSRN KWLKMIQILR EQGQENLH-- 
Cyp11b2               ---------- ------TLQP FEAIPQYSRN KWLKMIQILR EQGQENLH-- 
Cyp17                 ---------- ------KSKT PNAKFPRSLP FLPLVGSLPF LPRRGHMH-- 
Cyp19                 ---------- --LLLLIWNC ESSSSIPGPG YCLGIGPLIS HGRFLWMG-- 
Cyp20                 ---------- ------GLTP TEEKDGNLP- -------DIV NSGSLHE--- 
Cyp21                 ---------- ------GTRW LWGQWKLRKL HLPPLAPGFL HFLQPNLP-- 
Cyp24                 -----VPLCP LMTDGETRNV TSLPGPTNWP LLGSLLEIFW KGGLKKQH-- 
Cyp26a1               ---------- --------RS CALPLPPGTM GFPFFGETLQ MVLQRRK--- 
Cyp26b1               ---------- --------KS CKLPIPKGSM GFPLIGETGH WLLQGSG--- 
Cyp26c1               ---------- --------WA STLPLPKGSM GWPFFGETLH WLVQGSR--- 
Cyp27a1               ---------- ---Q-DRPRL RSPAELPGTG TLQFLFQLFL QGYVLHLP-- 
Cyp27b1               ---------- ---RGSESVL RSLSDIPGPS TLSFLAELFC KGGLSRLH-- 
Cyp39                 ---------- --------LK NLLGPPCIQG WIPWIGAGLE FGKAPLE--- 
Cyp46                 ---------- ------GPPR PSFLLGHLPY ---FWKKDED CGRVLQD--- 
Cyp51                 ---------- --------PA GAKSPPHIYS PIPFLGHAIA FGKSPIE--- 
CYP1A1h               ---------- ----SRPQVP KGLKNPPGPW GWPLIGHMLT LGKNPH---- 
CYP1A2h               ---------- ----LRPRVP KGLKSPPEPW GWPLLGHVLT LGKNPH---- 
CYP1B1h               ---------- ----LRQRRR QLRSAPPGPF AWPLIGNAAA VGQAAH---- 
CYP2A6                ---------- ------QQRK SKGKLPPGPT PLPFIGNYLQ LNTEQMY--- 
CYP2A7                ---------- ------QQRK SRGKLPPGPT PLPFIGNYLQ LNTEHIC--- 
CYP2A13               ---------- ------RQRK SRGKLPPGPT PLPFIGNYLQ LNTEQMY--- 
CYP2B6                ---------- ------RHPN THDRLPPGPR PLPLLGNLLQ MDRRGLL--- 
CYP2C8                ---------- ------RQSC RRRKLPPGPT PLPIIGNMLQ IDVKDIC--- 
CYP2C9                ---------- ------RQSS GRGKLPPGPT PLPVIGNILQ IGIKDIS--- 
CYP2C18               ---------- ------RQSS GRGRLPSGPT PLPIIGNILQ LDVKDMS--- 
CYP2C19               ---------- ------RQSS GRGKLPPGPT PLPVIGNILQ IDIKDVS--- 
CYP2D6                ---------- ----HRR-QR WAARYPPGPL PLPGLGNLLH VDFQNTP--- 
CYP2E1h               ---------- ------RQVH SSWNLPPGPF PLPIIGNLFQ LELKNIP--- 
CYP2F1                ---------- ------LSSR DKGKLPPGPR PLSILGNLLL LCSQDML--- 
CYP2G2P               ---------- ------KMN- KAGKLPPGPT PIPFLGNLLQ VRTDATF--- 
CYP2J2                ---------- ----DFLKRR RPKNYPPGPW RLPFLGNFFL VDFEQS---- 
CYP2R1h               ---------- ----QLLKQR RPMGFPPGPP GLPFIGNIYS LAASSEL--- 
CYP2S1h               ---------- ----ALSGTR ARGHLPPGPT PLPLLGNLLQ LRPGALY--- 
CYP2T2P               ---------- -------RAQ MRGSLPPRPR PLPLLG-NLQ LQSGGLD--- 
CYP2U1h               ---------- ----SWLRRR RARGIPPGPT PWPLVGNFGH VLLPPFLRRR 
CYP3A4                ---------- ------FKKL GIPGPTPLP- ---FLGNILS YHKG------ 
CYP3A5                ---------- ------FKRL GIPGPTPLP- ---LLGNVLS YRQG------ 
CYP3A7                ---------- ------FKKL GIPGPTPLP- ---FLGNALS FRKG------ 
CYP3A43               ---------- ------FKKL GIPGPTPLP- ---FLGTILF YLRG------ 
CYP4A11               ---------- ------WLLK ALQQFPCPPS -HWLFGHIQE LQQ--DQ--- 
CYP4A22               ---------- ------WLLK ALQQFPCPPS -HWLFGHIQE FQH--DQ--- 
CYP4B1h               ---------- ------TLAK AMDKFPGPPT -HWLFGHALE IQE--TG--- 
CYP4F2                ---------- ------DNCR RLRCFPQPPR RNWFWGHQGM IHSS-EE--- 
CYP4F3                ---------- ------DNCC RLRCFPQPPK RNWFLGHLGL IHSS-EE--- 
CYP4F8                ---------- ------HNGR RLRCFPQPRK QNWFLGHLGL VTPT-EE--- 
CYP4F11               ---------- ------DNCR RLQCFPQPPK QNWFWGHQGL VTPT-EE--- 
CYP4F12               ---------- ------NNCR RLQCFPQPPK RNWFWGHLGL ITPT-EE--- 
CYP4F22               ---------- ------ITCR RLRCFPQPPR RNWLLGHLGM VSPN-EA--- 
CYP4F23P              ---------- ------DNCH RLQCFQQPPK RNCFG-HLSL VSGN-EE--- 
CYP4V2                ---------- ------RKWQ QMRPIPTVAR AYPLVGHALL MKPDGRE--- 
CYP4X1h               ---------- ------RLLR DLRPFPAPPT -HWFLGHQKF IQ---DD--- 
CYP4Z1                ---------- ------WMIR ALHLFPAPPA -HWFYGHKEF YP---VK--- 
CYP5A1h               ---------- ------LEKL GLRHPKPSP- ---FIGNLTF FRQG------ 
CYP7A1h               ---------- ---------R QTGEPPLENG LIPYLGCALQ FGANPLE--- 
CYP7B1h               ---------- --------TR RPGEPPLIKG WLPYLGVVLN LRKDPLR--- 
CYP8A1h               ---------- --------TR RPGEPPLDLG SIPWLGYALD FGKDAAS--- 
CYP8B1h               ---------- --------QR RPWEPPLDKG TVPWLGHAMA FRKNMFE--- 
CYP11A1h              ---------- ------SPRP FNEIPSPGDN GWLNLYHFWR ETGTHKVH-- 
CYP11B1h              ---------- ------TVLP FEAMPRRPGN RWLRLLQIWR EQGYEDLH-- 
CYP11B2h              ---------- ------TVLP FEAMPQHPGN RWLRLLQIWR EQGYEHLH-- 
CYP17h                ---------- ------KRRC PGAKYPKSLL SLPLVGSLPF LPRHGHMH-- 
CYP19h                ---------- --LFLLVWNY EGTSSIPGPG YCMGIGPLIS HGRFLWMG-- 
CYP20h                ---------- ------GITP TEEKDGNLP- -------DIV NSGSLHE--- 
CYP21A2h              ---------- ------GARL LWNWWKLRSL HLPPLAPGFL HLLQPDLP-- 
CYP24h                -----VPVCP LTAGGETQNA AALPGPTSWP LLASLLQILW KGGLKKQH-- 
CYP26A1h              ---------- --------RS CALPLPPGTM GFPFFGETLQ MVLQRRK--- 
CYP26B1h              ---------- --------KS CKLPIPKGSM GFPLIGETGH WLLQGSG--- 
CYP26C1h              ---------- --------RA STLPLPKGSM GWPFFGETLH WLVQGSR--- 
CYP27A1h              ---------- ---PGVRRRQ RSLEEIPRLG QLRFFFQLFV QGYALQLH-- 
CYP27B1h              ---------- ---REYHSAR RSLADIPGPS TPSFLAELFC KGGLSRLH-- 
CYP27C1h              EDKGAGRPGS PPGGGRAEGP RSLAAMPGPR TLANLAEFFC RDGFSRIH-- 
CYP39A1h              ---------- --------RK NLRRPPCIKG WIPWIGVGFE FGKAPLE--- 
CYP46h                ---------- ------GPPR PSFLLGHLPC ---FWKKDEV GGRVLQD--- 
CYP51h                ---------- --------PA GVKSPPYIFS PIPFLGHAIA FGKSPIE--- 

Cyp1a1                ---------- ---------- LSLTRLSQQY GDVLQIRIGS T---PVVVLS 
Cyp1a2                ---------- ---------- LSLTRLSQQY GDVLQIRIGS T---PVVVLS 
Cyp1b1                ---------- ---------- LYFARLARRY GDVFQIRLGS C---PVVVLN 
Cyp2a4                ---------- ---------- NSLMKISQRY GPVFTIYLGS R---RIVVLC 
Cyp2a5                ---------- ---------- NSLMKISQRY GPVFTIYLGP R---RIVVLC 
Cyp2a12               ---------- ---------- SSITQLQEHY GPVFTIHLGP R---RVVVLY 
Cyp2b9                ---------- ---------- KCFIQLQEKH GDVFTVHLGP R---PVVVLC 
Cyp2b10               ---------- ---------- KSFIQLREKY GDVFTVHLGP R---PVVMLC 
Cyp2b13               ---------- ---------- KCFIHLQEKH GDVFTVHLGP R---PVVVLC 
Cyp2b19               ---------- ---------- SSFIQLQEKY GDVFTVHLGP R---PVVMLC 
Cyp2b23               ---------- ---------- KSFIKLRDKH GDVFTVHLGP R---PVVMLY 
Cyp2c29               ---------- ---------- QSFTNFSKAY GPVFTLYLGS K---PTVILH 
Cyp2c37               ---------- ---------- QSFTNLSKVY GPVYTLYLGR K---PTVVLH 
Cyp2c38               ---------- ---------- QSLTNFSKAY GPVFTLYLGS R---PIVVLH 
Cyp2c39               ---------- ---------- QSLTNFSKAY GPVFTLYLGS R---PTVVLH 
Cyp2c40               ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH 
Cyp2c44               ---------- ---------- ASLSKLAKEY GPVYTLYFGS W---PTVVLH 
Cyp2c50               ---------- ---------- QSFTNLSKVY GPVYTLYLGN K---PTVVLH 
Cyp2c54               ---------- ---------- QSFTNLSRVY GPVYTLYLGR K---PTVVLH 
Cyp2c55               ---------- ---------- KSFNYFSKVY GPVFTLYFGS K---PTVVVH 
Cyp2c65               ---------- ---------- KSLRNFSKVY GPVFTLYLGR N---PAVVLH 
Cyp2c66               ---------- ---------- KSLRNFSKVY GPVFTLYLGK K---PAVVLH 
Cyp2c67               ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH 
Cyp2c68               ---------- ---------- QCLTNFSKIY GPVFTLYFGS Q---PIVILH 
Cyp2c69               ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH 
Cyp2c70               ---------- ---------- KSMGMLAKKY GPVFTVYLGM K---PTVVLH 
Cyp2d9                ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN 
Cyp2d10               ---------- ---------- YSLYKLQNRY GDVFSLQMGW K---PMVVIN 
Cyp2d11               ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN 
Cyp2d12               ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN 
Cyp2d13               ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PVVVIS 
Cyp2d22               ---------- ---------- AGFQKLRGRY GDLFSLQLAS E---SVVVLN 
Cyp2d26               ---------- ---------- YSFYKLQNRY GNVFSLQMAW K---PVVVVN 
Cyp2e1                ---------- ---------- KSLTKLAKRF GPVFTLHLGQ R---RIVVLH 
Cyp2f2                ---------- ---------- TSLTKLSKEY GSVFTVYLGS R---PVIVLS 
Cyp2g1                ---------- ---------- QSFQKLQKKY GSVFTVYFGP R---PVVVLC 
Cyp2j5                ---------- ---------H LVLQQFVKKY GNVFSLELGQ S---PVVVVS 
Cyp2j6                ---------- ---------H LSIQPLVKKY GNIFSLNLGD I---TSVVIT 
Cyp2j7                ---------- --------LH LRIQLFVKKY GNLISIDFGN I---SSVVIT 
Cyp2j8                ---------- --------LH LGIQPFVKKY GNLISLDFGT I---PSVIIS 
Cyp2j9                ---------- ---------H LSLQQFVKKY GNVLSLDFAN I---PSVVIT 
Cyp2j13               ---------- ---------H LAVQKFVKKY GNVISLDFGI K---SAVIIS 
Cyp2j12               ---------- ---------H VVIQQFVKKY GNLTSLDFGN I---PSVIIT 
cyp2j11               ---------- --------LH LGIQPFVKKY GNVISVNFGY I---SSVIIS 
Cyp2r1                ---------- --------PH VYMRKQSRVY GEIFSLDLGG I---STVVLN 
Cyp2s1                ---------- ---------- SGLLRLSKKY GPVFTVYLGP W--RRVVVLV 
Cyp2t4                ---------- ---------- RVLMELSSHW GPVFTVWLGP L---PAVVLC 
Cyp2U1                FWLGS----- GSQTDTVGQH VYLARMARVY GNIFSFFIGH R---LVVVLS 
Cyp2w1                ---------- ---------- RALMELSERY GPMFTIHLGS Q---KTVVLS 
CYP2W1h               ---------- ---------- RSLMELSERY GPVFTVHLGR Q---KTVVLT 
Cyp3a11               ---------- --------LW KFDMECYKKY GKTWGLFDGQ --T-PLLAVT 
Cyp3a13               ---------- --------FW ECDIQCHKKY GKMWGLYDGR --Q-PVLAIT 
Cyp3a16               ---------- --------LW KFDMECYEKY GKTWGLFDGQ --I-PLFVIT 
Cyp3a25               ---------- --------MW KFDEDCYKKY GKIWGFYEGP --Q-PILAIM 
Cyp3a57               ---------- --------MW KFDDDCYKKY GKIWGFYEGP --Q-PILAIM 
Cyp3a41               ---------- --------LW KFDMECYEKY GKTWGLFDGQ --M-PLFVIT 
Cyp3a44               ---------- --------IW KFDMECYEKY GKTWGLFDGQ --T-PLLVIT 
Cyp4a10               ---------- --------EL QEIVSCIENF PSAFPRWFWG -SK-AYLTVY 
Cyp4a12               ---------- --------DL QDILTRIKNF PSACPQWLWG -SK-VRIQVY 
Cyp4a14               ---------- --------EL QQILIWVEKF PSACLQCLSG -SN-IRVLLY 
Cyp4a30               ---------- --------DL QQILLCVEKF PSTYVRWLWG -NH-ARVVIY 
Cyp4a29               ---------- --------EL RWILRYLEKF PGAFLHWIWG -SH-VFIKVC 
Cyp4b1                ---------- --------GL DKVVTWTEQF PYAHPLWLGQ -FI-VFLNIY 
Cyp4f13               ---------- --------SM QFITHLGHDF HDVHLSWVGP -VY-PILRLV 
Cyp4f14               ---------- --------GL KELTRLVGTY PQGFLMWIGP -MV-PVITLC 
Cyp4f15               ---------- --------GL KEVTNLVATY PQGFMTWLGP -II-PIITLC 
Cyp4f16               ---------- --------GM QLVTEMGQAF QDVHLFWLGP -VI-PVLRIV 
Cyp4f17               ---------- --------GL QLLTERSHQF HDVHLCWIGP -FY-PILRLI 
Cyp4f18               ---------- --------GL LYIQSLVRTF RDACCWWVGP -LH-PVIRIF 
Cyp4f37               ---------- --------GM QLMTEAGQTY RDVHLCWLGP -VI-PVLRIV 
Cyp4f39               ---------- --------GL QNEKKVLDTM HHIILAWVGP -FL-PLLVLV 
Cyp4f40               ---------- --------GM KQVTELVTTY PQGFMTWLGP -IV-PLITLC 
Cyp4v3                ---------- --------FF QQLIYYTEEF RHLPIIKLWI GPV-PLVALY 
Cyp4x1                ---------- --------NM ETLDEIVKKH PCAFPCWVGP -FQ-AFFYIY 
Cyp5a1                ---------- --------FW ESQLELRERY GPLCGYYLGR --R-MHVVIS 
Cyp7a1                ---------- ---------- -FLRAKQRKH GHVFTCKLMG K---YVHFIT 
Cyp7b1                ---------- ---------- -FLKTLQRQH GDTFTVFLVG K---YITFVL 
Cyp8a1                ---------- ---------- -FLTRMKEKH GDIFTVLVGG R---YVTVLL 
Cyp8b1                ---------- ---------- -FLKGMRAKH GDVFTVQLGG Q---YFTFVM 
Cyp11a1               ---------- ---------- YHQMQSFQKY GPIYREKLGT L---ESVYIV 
Cyp11b1               ---------- ---------- LEMHQVFREL GPIFRHSVGK T---QIVFVT 
Cyp11b2               ---------- ---------- LEMHQVFREL GPIFRHSVGK T---QIVSVM 
Cyp17                 ---------- ---------- ANFFKLQEKY GPIYSLRLGT T---TAVIVG 
Cyp19                 ---------- --------IG SACNYYNKMY GEFMRVWISG E--ETLIISK 
Cyp20                 ---------- --------FL VNLHERYGPV V---SFWFGR RLV-VSLGTT 
Cyp21                 ---------- ---------- IYLLGLTQKL GPIYRIRLGM Q---DVVVLN 
Cyp24                 ---------- ---------- DTLAEYHKKY GQIFRMKLGS F---DSVHLG 
Cyp26a1               ---------- ---------- -FLQMKRRKY GFIYKTHLFG R---PTVRVM 
Cyp26b1               ---------- ---------- -FQSSRREKY GNVFKTHLLG R---PLIRVT 
Cyp26c1               ---------- ---------- -FHSSRRERY GTVFKTHLLG R---PVIRVS 
Cyp27a1               ---------- ---------- DLQVLNKTKY GPMWTTSFGT Y---TNVNLA 
Cyp27b1               ---------- ---------- ELQVHGAARY GPIWSGSFGT L---RTVYVA 
Cyp39                 ---------- ---------- -FIEKARIKY GPVFTIFAMG N---RMTFVS 
Cyp46                 ---------- --------VF LDWAKKYGPV VRVNVFYKTS VIV-TSPESV 
Cyp51                 ---------- ---------- -FLENAYEKY GPVFSLTMVG K---TFTYLL 
CYP1A1h               ---------- ---------- LALSRMSQQY GDVLQIRIGS T---PVVVLS 
CYP1A2h               ---------- ---------- LALSRMSQRY GDVLQIRIGS T---PVLVLS 
CYP1B1h               ---------- ---------- LSFARLARRY GDVFQIRLGS C---PIVVLN 
CYP2A6                ---------- ---------- NSLMKISERY GPVFTIHLGP R---RVVVLC 
CYP2A7                ---------- ---------- DSIMKFSECY GPVFTIHLGP R---RVVVLC 
CYP2A13               ---------- ---------- NSLMKISERY GPVFTIHLGP R---RVVVLC 
CYP2B6                ---------- ---------- KSFLRFREKY GDVFTVHLGP R---PVVMLC 
CYP2C8                ---------- ---------- KSFTNFSKVY GPVFTVYFGM N---PIVVFH 
CYP2C9                ---------- ---------- KSLTNLSKVY GPVFTLYFGL K---PIVVLH 
CYP2C18               ---------- ---------- KSLTNFSKVY GPVFTVYFGL K---PIVVLH 
CYP2C19               ---------- ---------- KSLTNLSKIY GPVFTLYFGL E---RMVVLH 
CYP2D6                ---------- ---------- YCFDQLRRRF GDVFSLQLAW T---PVVVLN 
CYP2E1h               ---------- ---------- KSFTRLAQRF GPVFTLYVGS Q---RMVVMH 
CYP2F1                ---------- ---------- TSLTKLSKEY GSMYTVHLGP R---RVVVLS 
CYP2G2P               ---------- ---------- QSFMKLREKY SPVFTVYMGP R---PVVVLC 
CYP2J2                ---------- ---------H LEVQLFVKKY GNLFSLELGD I---SAVLIT 
CYP2R1h               ---------- --------PH VYMRKQSQVY GEIFSLDLGG I---STVVLN 
CYP2S1h               ---------- ---------- SGLMRLSKKY GPVFTIYLGP W--RPVVVLV 
CYP2T2P               ---------- ---------- RALHSLSGRW GRVFTVRLGP R---PAVGLC 
CYP2U1h               SWLSSRTRAA GIDPSVIGPQ VLLAHLARVY GSIFSFFIGH Y---LVVVLS 
CYP3A4                ---------- --------FC MFDMECHKKY GKVCGFYDGQ --Q-PVLAIT 
CYP3A5                ---------- --------LW KFDTECYKKY GKMWGTYEGQ --L-PVLAIT 
CYP3A7                ---------- --------YW TFDMECYKKY RKVWGIYDCQ --Q-PMLAIT 
CYP3A43               ---------- --------LW NFDRECNEKY GEMWGLYEGQ --Q-PMLVIM 
CYP4A11               ---------- --------EL QRIQKWVETF PSACPHWLWG -GK-VRVQLY 
CYP4A22               ---------- --------EL QRIQERVKTF PSACPYWIWG -GK-VRVQLY 
CYP4B1h               ---------- --------SL DKVVSWAHQF PYAHPLWFGQ -FI-GFLNIY 
CYP4F2                ---------- --------GL LYTQSLACTF GDMGCWWVGP -WQ-AVIHIF 
CYP4F3                ---------- --------GL LYTQSLACTF GDMCCWWVGP -WH-AIVRIF 
CYP4F8                ---------- --------GL RVLTQLVATY PQGFVRWLGP -IT-PIINLC 
CYP4F11               ---------- --------GM KTLTQLVTTY PQGFKLWLGP -TF-PLLILC 
CYP4F12               ---------- --------GL KDSTQMSATY SQGFTVWLGP -II-PFIVLC 
CYP4F22               ---------- --------GL QDEKKVLDNM HHVLLVWMGP -VL-PLLVLV 
CYP4F23P              ---------- --------DM RLMEDLGHYF RDVQLWWLGS -FY-PVLHLV 
CYP4V2                ---------- --------FF QQIIEYTEEY RHMPLLKLWV GPV-PMVALY 
CYP4X1h               ---------- --------NM EKLEEIIEKY PRAFPFWIGP -FQ-AFFCIY 
CYP4Z1                ---------- --------EF EVYHKLMEKY PCAVPLWVGP -FT-MFFSVH 
CYP5A1h               ---------- --------FW ESQMELRKLY GPLCGYYLGR --R-MFIVIS 
CYP7A1h               ---------- ---------- -FLRANQRKH GHVFTCKLMG K---YVHFIT 
CYP7B1h               ---------- ---------- -FMKTLQKQH GDTFTVLLGG K---YITFIL 
CYP8A1h               ---------- ---------- -FLTRMKEKH GDIFTILVGG R---YVTVLL 
CYP8B1h               ---------- ---------- -FLKRMRTKH GDVFTVQLGG Q---YFTFVM 
CYP11A1h              ---------- ---------- LHHVQNFQKY GPIYREKLGN V---ESVYVI 
CYP11B1h              ---------- ---------- LEVHQTFQEL GPIFRYDLGG A---GMVCVM 
CYP11B2h              ---------- ---------- LEMHQTFQEL GPIFRYNLGG P---RMVCVM 
CYP17h                ---------- ---------- NNFFKLQKKY GPIYSVRMGT K---TTVIVG 
CYP19h                ---------- --------IG SACNYYNRVY GEFMRVWISG E--ETLIISK 
CYP20h                ---------- --------FL VNLHERYGPV V---SFWFGR RLV-VSLGTV 
CYP21A2h              ---------- ---------- IYLLGLTQKF GPIYRLHLGL Q---DVVVLN 
CYP24h                ---------- ---------- DTLVEYHKKY GKIFRMKLGS F---ESVHLG 
CYP26A1h              ---------- ---------- -FLQMKRRKY GFIYKTHLFG R---PTVRVM 
CYP26B1h              ---------- ---------- -FQSSRREKY GNVFKTHLLG R---PLIRVT 
CYP26C1h              ---------- ---------- -FHSSRRERY GTVFKTHLLG R---PVIRVS 
CYP27A1h              ---------- ---------- QLQVLYKAKY GPMWMSYLGP Q---MHVNLA 
CYP27B1h              ---------- ---------- ELQVQGAAHF GPVWLASFGT V---RTVYVA 
CYP27C1h              ---------- ---------- EIQQKHTREY GKIFKSHFGP Q---FVVSIA 
CYP39A1h              ---------- ---------- -FIEKARIKY GPIFTVFAMG N---RMTFVT 
CYP46h                ---------- --------VF LDWAKKYGPV VRVNVFHKTS VIV-TSPESV 
CYP51h                ---------- ---------- -FLENAYEKY GPVFSFTMVG K---TFTYLL 

Cyp1a1                GLNTIKQALV RQGDDFKGRP D-LYSFTLIT NG---KSMTF NPDSGPVWAA 
Cyp1a2                GLNTIKQALV RQGDDFKGRP D-LYSFTLIT NG---KSMTF NPDSGPVWAA 
Cyp1b1                GESAIHQALV QQGSIFADRP P-FASFRVVS GG---RSLAF G-HYSEHWKT 
Cyp2a4                GQEAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGIAF S--SGERAKQ 
Cyp2a5                GQEAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGVVF S--SGERAKQ 
Cyp2a12               GYDAVKEALV DHAEEFSGRG E-QATFNTLF KG---YGVAF S--NGERAKQ 
Cyp2b9                GTQTIREALV DHAEAFSGRG T-IAAAQLVM QD---YGIFF A--SGQRWKT 
Cyp2b10               GTDTIREALV GQAEAFSGRG T-VAVVEPTF KE---YGVIF A--NGERWKT 
Cyp2b13               GTQTIREALV NNAEAFSGRG T-IAAAQLVM QD---YGIFF S--SGERWKT 
Cyp2b19               GTDTIREALV NQAEAFSGRG T-VAVLDPIV QG---YGVIF S--SGERWKT 
Cyp2b23               GTETIKEALV DHSDAFSGRG A-IAVIQPIV QD---YGVIF S--SGERWKT 
Cyp2c29               GYEAVKEALI DRGEEFAGRG S-FPMAEKMI KG---FGVVF S--NGNRWKE 
Cyp2c37               GYEAVKEALV DHGEEFAGRG R-FPVFDKAT NG---MGLAF S--KGNVWKN 
Cyp2c38               GYEAVKEALI DHGEEFSGRG N-IPMSEKIN NG---LGITF S--NGNSWKE 
Cyp2c39               GYEAVKEALI DHGEEFSDRG S-IPMVEKIN NG---LGIVF S--NGNRWKE 
Cyp2c40               GYEAIKEALI DHGEEFSGRG R-IPVFDKVS TG---KGIGF S--HGNVWKA 
Cyp2c44               GYDVVKEALL NQGDEFLGRG P-LPIIEDSQ KG---HGIVF S--EGERWKL 
Cyp2c50               GYEAVKEALV DHGEEFAGRG R-LPVFDKAT NG---MGIIF S--KGNVWKN 
Cyp2c54               GYEAVKEALV DHGDVFAGRG R-LPVFDKAT NG---MGIGF S--NGSVWKN 
Cyp2c55               GYEAVKEALD DLGEEFSGRG S-FQIFERIN ND---LGVIF S--NGTKWKE 
Cyp2c65               GYEAVKEAFT DHGEEFAGRG V-FPVFDKFK KN---CGVVF S--SGRTWKE 
Cyp2c66               GYKAVKEALI DHGEEFAGRG T-FPVADKFI RV---LGVVF S--SGRTWKE 
Cyp2c67               GYEAMKEAFI DHGEEFSGRG R-FPFFDKVT KG---KGIGF S--HGNVWKA 
Cyp2c68               GYEAMKEAFI DYGEEFSGRG R-IPVFDKVS KG---KGIGF S--HGNVWKA 
Cyp2c69               GYEAIKEALI DHGEVFSGRG R-FPFFDKVS KG---KGIGF S--HGNVWKA 
Cyp2c70               GYKAMKEALI DQGDEFSDKT D-SSLLSRTS QG---LGIVF S--NGETWKQ 
Cyp2d9                GLKAMKEMLL TCGEDTADRP P-VPIFEYLG VKPGSQGVVL AP-YGPEWRE 
Cyp2d10               GLKAMKEVLL TCGEDTADRP Q-VPIFEYLG VKPGSQGVVL AP-YGPEWRE 
Cyp2d11               GLKAMKEMLL TCGEDTADRP P-VPIFEYLG VKPGSQGVVL AP-YGPEWRE 
Cyp2d12               RMKAMKEVLL TCGEDTADRP P-VPIFEHLG FKPRSQGMIF AP-YGPEWRE 
Cyp2d13               GLKAVREVLV TCGEDTADRP E-MPIFQHLG YGEKAKGVVF AP-YGPEWRE 
Cyp2d22               GLTALREALV KHSEDTADRP P-LHFNDLLG FGPRSQGIVL AR-YGPAWRQ 
Cyp2d26               GLKAVRELLV TYGEDTSDRP L-MPIYNHIG YGHKSKGVIL AP-YGPEWRE 
Cyp2e1                GYKAVKEVLL NHKNEFSGRG D-IPVFQEYK N----KGIIF N--NGPTWKD 
Cyp2f2                GYQTVKEALV DKGEEFSGRG A-YPVFFNFT RG---NGIAF S--DGERWKI 
Cyp2g1                GHEAVKEALV DQADDFSGRG E-MPTLEKNF QG---YGLAL S--NGERWKI 
Cyp2j5                GLPLIKEMFT HLDQNFVNRF M-TPVRERIT GK---NGLVV S--NGQTWKE 
Cyp2j6                GLPLIKEALT QMEQNIMNRP L-SVMQERIS NK---NGLIF S--SGQIWKE 
Cyp2j7                GLPLIKEAFT DMEQNLLKRP I-IPSRKHVF KD---NGIIF S--SGQKWKE 
Cyp2j8                GEPLIKEALT CMGQNFLKRP I-LAARQHIF KN---NGIIS S--SGQTWKE 
Cyp2j9                GMPLIKEIFT QMEHNFMNRP V-TLLRKHLF NK---NGLIF S--SDQTWKE 
Cyp2j13               SLPLIKEAFS HLDENFINRR I-FPLQRQIF NG---NGLIF S--SGQTWKE 
Cyp2j12               GLPLIKEVFT NMEQNFLNRP I-TPIRKRVF NN---NGLII S--NGQTWKE 
cyp2j11               GLPLIKEAIT GMEQNFLKRP S-LAARQHVF KN---NGIVF S--SGQTWKE 
Cyp2r1                GYDVVKECLV HQSEIFADRP C-LPLFMKMT KM---GGLLN SR-YGRGWID 
Cyp2s1                GHDAVREALG GQAEEFSGRG T-LATLDKTF DG---HGVFF A--NGERWKQ 
Cyp2t4                GYEALRDALV LQADAFSGRG A-MAVFDRFT CG---NGIVF S--NGPRWHS 
Cyp2U1                DFHSVREALV QQAEVFSDRP R-MPLISIMT KE---KGIVF AH-YGPIWKQ 
Cyp2w1                GYEVVREALV GTGHELADRP P-IPIFQHIQ RG---GGIFF S--SGARWRA 
CYP2W1h               GFEAVKEALA GPGQELADRP P-IAIFQLIQ RG---GGIFF S--SGARWRA 
Cyp3a11               DPETIKNVLV KECFS---VF TNRRDFGPVG IM---SKAIS IS-KDDEWKR 
Cyp3a13               DPDIIKTVLV KECYS---TF TNRRRFGPVG IL---KKAIS IS-ENEEWKR 
Cyp3a16               DPETIKNVLV KECFS---VF TNRQDFFPVG IM---SKSIS LA-KDEEWKR 
Cyp3a25               DPEIIKIVLV KECYS---VF TNRRFFGPVG FM---KKAIT IS-EDEEWKR 
Cyp3a57               DPEIIKIVLV KECYS---VF TNRRPFGPVG FL---KKSIT IS-EDEEWKR 
Cyp3a41               DPEMIKNVLV KECFS---VF TNRREFGPVG IM---SKAIS IS-KDEEWKR 
Cyp3a44               DPETIKNVLV KDCLS---VF TNRREFGPVG IM---SKAIS IS-KDEEWKR 
Cyp4a10               DPDYMKVILG RS----DPKA NGAYRLLAPW IG---YGLLL LN-G-QPWFQ 
Cyp4a12               DPDYMKLILG RS----DPKA NGSYRFLAPW IG---RGLLL LD-G-QTWFQ 
Cyp4a14               DPDYVKVVLG RS----DPKA SGIYQFFAPW IG---YGLLL LN-G-KKWFQ 
Cyp4a30               DPDYMKVILG RS----DPKV VRSYSFFAPW IG---YGLLL LN-G-KKWFQ 
Cyp4a29               DPDYMKVILG RA----SDPK ASLYRFLTPW LG---HGLFF LN-G-DEWFQ 
Cyp4b1                EPDYAKAVYS RG----DPKA AYVYDFFLQW IG---KGLLV LE-G-PKWFQ 
Cyp4f13               HPNFIAPLLQ AS-AAVAPKE MTLYGFLKPW LG---DGLLM SA-G-DKWSH 
Cyp4f14               HSDIVRSILN AS-AAVALKD VIFYSILKPW LG---DGLLV SA-G-DKWSR 
Cyp4f15               HPDIIRSVLN AS-ASVALKE VVFYSFLKPW LG---DGLLL SD-G-DKWSS 
Cyp4f16               DPAFVAPLLQ AP-ALVAPKD MTFLRFLKPW LG---DGLFL SS-G-DKWSR 
Cyp4f17               HPKFIGSILQ AS-AAVAPKE MIFYGFLKPW LG---DGLLV SA-G-EKWSR 
Cyp4f18               HPAFIKPVVL AP-ALVAPKD TVFYRFLKPW LG---DGLLM ST-G-DKWSR 
Cyp4f37               DPAFVAPLLL AT-ALVAPKD TTFHTFVKPW LG---DGLFL NS-G-DKWSR 
Cyp4f39               HPDYIKPVLG AS-AAIAPKD EFFYSFLKPW LG---DGLLI SK-G-NKWSR 
Cyp4f40               HPDIIRSVLS ASSAAVAPKD DIFYSFLKPW LG---DGLLV SA-G-DKWNR 
Cyp4v3                KAENVEVILT SS--K-QIDK SFLYKFLQPW LG---LGLLT ST-G-SKWRT 
Cyp4x1                DPDYAKIFLS RT----G--- ---------- -----RGLLN LD-G-PRWFQ 
Cyp5a1                EPDMIKQVLV ENFSN---FS NRMASGLEPK MV---ADSVL LL-RDRRWEE 
Cyp7a1                NSLSYHKVLC HGK-YFDWKK F-HYTTSAKA FG---HRSID PS-DGNTTEN 
Cyp7b1                NPFQYQYVTK NPK-QLSFQK F-SSRLSAKA FS---VKKLL TD-DDLNED- 
Cyp8a1                DPHSYDTVVW ELRTRLDFHP Y-AIFLMERI FD---LQLPN FN-PSEEKA- 
Cyp8b1                DPLSFGPIIK NTEKALDFQS Y-AKELVLKV FG---YQSVD GD-HRMIHL- 
Cyp11a1               DPKDASILFS CEGPNPERFL V-PPWVAYHQ YYQRPIGVLF K--SSDAWKK 
Cyp11b1               LPEDVEKLYQ VESTHPCRMP L-ESWIVHRE LRGLGRGVFL L--NGPEWYF 
Cyp11b2               LPEDAEKLHQ VESMLPRRMH L-EPWVAHRE LRGLRRGVFL L--NGPEWRL 
Cyp17                 HYQLAREVLV KKGKEFSGRP Q-MVTLGLLS DQG--KGVAF AD-SSSSWQL 
Cyp19                 SSSMFHVMKH SHYISRFGSK R-GLQCIGMH EN----GIIF NN-NPSLWRT 
Cyp20                 DVLKQHFNPN KT---SDPFE TMLKSLLGYQ SG---GGSAG ED------HV 
Cyp21                 SNRTIEEALI QKWVDFAGRP -----HMLNG KMD--LDLSL GD-YSLMWKA 
Cyp24                 SPSLLEALYR TESAHPQRLE I-KPWKAYRD HRNEAYGLMI L--EGQEWQR 
Cyp26a1               GADNVRRILL GEH--RLVSV H-WPASVRTI LG---AGCLS NL-HDSSHKQ 
Cyp26b1               GAENVRKILL GEH--QLVST E-WPRSARVL LG---PNTVA NS-IGDIHRN 
Cyp26c1               GAENVRTILL GEH--RLVRS Q-WPQSAHIL LG---SHTLL GA-VGEPHRQ 
Cyp27a1               SAPLLEQVMR QEGKYPIRDH M-DQWKDHRD HKGLTYGIFI A--QGEQWYH 
Cyp27b1               DPTLVEQLLR QESHCPERCS F-SSWAEHRR RHQRACGLLT A--DGEEWQR 
Cyp39                 EEEGINVLLK SEHVDFESAV Q-SPVYHTAW IP---KNVFS AL-HERLYAL 
Cyp46                 KKFLMSTKYN KD---SKMYR ALQTVFGERL FG---QGLVS EC-DYGRWYK 
Cyp51                 GSDAAALLFN SKNEDLNAEE V-YGRLTTPV FG---KGVAY DV-PNAIFLE 
CYP1A1h               GLDTIRQALV RQGDDFKGRP D-LYTFTLIS NG---QSMSF SPDSGPVWAA 
CYP1A2h               RLDTIRQALV RQGDDFKGRP D-LYTSTLIT DG---QSLTF STDSGPVWAA 
CYP1B1h               GERAIHQALV QQGSAFADRP A-FASFRVVS GG---RSMAF G-HYSEHWKV 
CYP2A6                GHDAVREALV DQAEEFSGRG E-QATFDWVF KG---YGVVF S--NGERAKQ 
CYP2A7                GHDAVREALV DQAEEFSGRG E-QATFEWVF KG---YGVAF S--NGERAKQ 
CYP2A13               GHDAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGVAF S--NGERAKQ 
CYP2B6                GVEAIREALV DKAEAFSGRG K-IAMVDPFF RG---YGVIF A--NGNRWKV 
CYP2C8                GYEAVKEALI DNGEEFSGRG N-SPISQRIT KG---LGIIS S--NGKRWKE 
CYP2C9                GYEAVKEALI DLGEEFSGRG I-FPLAERAN RG---FGIVF S--NGKKWKE 
CYP2C18               GYEAVKEALI DHGEEFSGRG S-FPVAEKVN KG---LGILF S--NGKRWKE 
CYP2C19               GYEVVKEALI DLGEEFSGRG H-FPLAERAN RG---FGIVF S--NGKRWKE 
CYP2D6                GLAAVREALV THGEDTADRP P-VPITQILG FGPRSQGVFL AR-YGPAWRE 
CYP2E1h               GYKAVKEALL DYKDEFSGRG D-LPAFHAHR D----RGIIF N--NGPTWKD 
CYP2F1                GYQAVKEALV DQGEEFSGRG D-YPAFFNFT KG---NGIAF S--SGDRWKV 
CYP2G2P               GHEAVKEALV DQADEFSGRG E-LASIKQNF QG---HGVAL A--NGERWRI 
CYP2J2                GLPLIKEALI HMDQNFGNRP V-TPMREHIF KK---NGLIM S--SGQAWKE 
CYP2R1h               GYDVVKECLV HQSEIFADRP C-LPLFMKMT KM---GGLLN SR-YGRGWVD 
CYP2S1h               GQEAVREALG GQAEEFSGRG T-VAMLEGTF DG---HGVFF S--NGERWRQ 
CYP2T2P               GYAALRDALV LQADAVSGRG S-MAVFERFT RG---NGILF S--NRPCWWT 
CYP2U1h               DFHSVREALV QQAEVFSDRP R-VPLISIVT KE---KGVVF AH-YGPVWRQ 
CYP3A4                DPDMIKTVLV KECYS---VF TNRRPFGPVG FM---KSAIS IA-EDEEWKR 
CYP3A5                DPDVIRTVLV KECYS---VF TNRRSLGPVG FM---KSAIS LA-EDEEWKR 
CYP3A7                DPDMIKTVLV KECYS---VF TNRRPFGPVG FM---KNAIS IA-EDEEWKR 
CYP3A43               DPDMIKTVLV KECYS---VF TNQMPLGPMG FL---KSALS FA-EDEEWKR 
CYP4A11               DPDYMKVILG RS----DPKS HGSYRFLAPW IG---YGLLL LN-G-QTWFQ 
CYP4A22               DPDYMKVILG RS----DPKS HGSYKFLAPR IG---YGLLL LN-G-QTWFQ 
CYP4B1h               EPDYAKAVYS RG----DPKA PDVYDFFLQW IG---RGLLV LE-G-PKWLQ 
CYP4F2                LPTCIKPVLF AS-AAIAPKD KFFYSFLEPW LG---DGLLL SA-G-DKWSR 
CYP4F3                HPTYIKPVLF AP-AAIVPKD KVFYSFLKPW LG---DGLLL SA-G-EKWSR 
CYP4F8                HPDIVRSVIN TS-DAITDKD IVFYKTLKPW LG---DGLLL SV-G-DKWRH 
CYP4F11               HPDIIRPITS AS-AAVAPKD MIFYGFLKPW LG---DGLLL SG-G-DKWSR 
CYP4F12               HPDTIRSITN AS-AAIAPKD NLFIRFLKPW LG---EGILL SG-G-DKWSR 
CYP4F22               HPDYIKPLLG AS-AAIAPKD DLFYGFLKPW LG---DGLLL SK-G-DKWSR 
CYP4F23P              HPTFTAPVLQ AS-AAVALKD MSFYGFLKPW LG---DGLLI SA-G-DKWRW 
CYP4V2                NAENVEGILT SS--K-QIDK SSMYKFLEPW LG---LGLLT ST-G-NKWRS 
CYP4X1h               DPDYAKTLLS RT----DPKS QYLQKFSPPL LG---KGLAA LD-G-PKWFQ 
CYP4Z1                DPDYAKILLK RQ----DPKS AVSHKILESW VG---RGLVT LD-G-SKWKK 
CYP5A1h               EPDMIKQVLV ENFSN---FT NRMASGLEFK SV---ADSVL FL-RDKRWEE 
CYP7A1h               NPLSYHKVLC HGK-YFDWKK F-HFATSAKA FG---HRSID PM-DGNTTEN 
CYP7B1h               DPFQYQLVIK NHK-QLSFRV F-SNKLLEKA FS---ISQLQ KN-HDMNDE- 
CYP8A1h               DPHSYDAVVW EPRTRLDFHA Y-AIFLMERI FD---VQLPH YS-PSDEKA- 
CYP8B1h               DPLSFGPILK DTQRKLDFGQ Y-AKKLVLKV FG---YRSVQ GD-HEMIHS- 
CYP11A1h              DPEDVALLFK SEGPNPERFL I-PPWVAYHQ YYQRPIGVLL K--KSAAWKK 
CYP11B1h              LPEDVEKLQQ VDSLHPHRMS L-EPWVAYRQ HRGHKCGVFL L--NGPEWRF 
CYP11B2h              LPEDVEKLQQ VDSLHPCRMI L-EPWVAYRQ HRGHKCGVFL L--NGPEWRF 
CYP17h                HHQLAKEVLI KKGKDFSGRP Q-MATLDIAS NNR--KGIAF AD-SGAHWQL 
CYP19h                SSSMFHIMKH NHYSSRFGSK L-GLQCIGMH EK----GIIF NN-NPELWKT 
CYP20h                DVLKQHINPN KT---SDPFE TMLKSLLRYQ SG---GGSVS EN------HM 
CYP21A2h              SKRTIEEAMV KKWADFAGRP E-PLTYKLVS RNY--PDLSL GD-YSLLWKA 
CYP24h                SPCLLEALYR TESVP-QRLE I-KPWKAYRD YRKEGYGLLI L--EGEDWQR 
CYP26A1h              GADNVRRILL GDD--RLVSV H-WPASVRTI LG---SGCLS NL-HDSSHKQ 
CYP26B1h              GAENVRKILM GEH--HLVST E-WPRSTRML LG---PNTVS NS-IGDIHRN 
CYP26C1h              GAENVRTILL GEH--RLVRS Q-WPQSAHIL LG---SHTLL GA-VGEPHRR 
CYP27A1h              SAPLLEQVMR QEGKYPVRND M-ELWKEHRD QHDLTYGPFT T--EGHHWYQ 
CYP27B1h              APALVEELLR QEGPRPERCS F-SPWTEHRR CRQRACGLLT A--EGEEWQR 
CYP27C1h              DRDMVAQVLR AEGAAPQRAN M-ESWREYRD LRGRATGLIS A--EGEQWLK 
CYP39A1h              EEEGINVFLK SKKVDFELAV Q-NIVYRTAS IP---KNVFL AL-HEKLYIM 
CYP46h                KKFLMSTKYN KD---SKMYR ALQTVFGERL FG---QGLVS EC-NYERWHK 
CYP51h                GSDAAALLFN SKNEDLNAED V-YSRLTTPV FG---KGVAY DV-PNPVFLE 

Cyp1a1                RRRLAQNALK SFSIASDPTS ASSCYLEEHV SKEANYLVSK LQKVMAEVG- 
Cyp1a2                RRRLAQDALK SFSIASDPTS ASSCYLEEHV SKEANHLVSK LQKAMAEVG- 
Cyp1b1                QRRSAYSTMR AFSTRHPRSR G---LLEGHA LAEARELVAV LVRRCAGGA- 
Cyp2a4                LRSFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDS FRKTNGAF-- 
Cyp2a5                LRRFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDS FRKTNGAF-- 
Cyp2a12               LRRFSIATLR DFGMGKRG-- -----VEEHI QEEAGCLIKM LQGTCGAP-- 
Cyp2b9                LRRFSLATMK EFGMGKRS-- -----VEERI KEEAQCLVEE LKKYQGVP-- 
Cyp2b10               LRRFSLATMR DFGMGKRS-- -----VEERI QEEAQCLVEE LRKSQGAP-- 
Cyp2b13               LRRFSLATMK EFGMGKRS-- -----VEERI KEEAQCLVEE LKKYQGAP-- 
Cyp2b19               LRRFSLATMR DFGMGKRS-- -----VEERI KEEAQCLVEE LKKYKGAP-- 
Cyp2b23               LRRFSLATMR DFGMGKRS-- -----VEERI KEEAQCLVEE LKKYEGAP-- 
Cyp2c29               MRRFTLMTLR NLGMGKRN-- -----IEDRV QEEAQCLVEE LRKTKGSP-- 
Cyp2c37               TRRFSLMTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- 
Cyp2c38               TRHFTLMTLR NLGMGKRN-- -----IEDRV REEAQCLVEE LRKTKGSP-- 
Cyp2c39               IRRFTLTTLR NLGMGKRN-- -----IEDRV QEEAQCLVEE LRKTKGSP-- 
Cyp2c40               TRVFTVNTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGSP-- 
Cyp2c44               LRRFSLMTLK NFGMGKRS-- -----LEERV QEEARCLVEE LHKTEAQP-- 
Cyp2c50               TRRFSLTTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- 
Cyp2c54               TRHFSLMTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- 
Cyp2c55               LRRFSIMTLR SFGMGKRS-- -----IEDRI QEEASCLVEE LRKANGSL-- 
Cyp2c65               MRRFSLMTLR NFGMGRRS-- -----IEDRI QEEARCLVDE LRKTKGEP-- 
Cyp2c66               MRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVDE LRKTKGVP-- 
Cyp2c67               TRVFTINTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGLP-- 
Cyp2c68               TRVFTVNTLR NLGMGKRT-- -----IETKV QEEAQWLMKE LKKTNGSP-- 
Cyp2c69               TRVFTVNTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGSP-- 
Cyp2c70               TRRFSLMVLR SMGMGKKT-- -----IEDRI QEEILYMLDA LRKTNGSP-- 
Cyp2d9                QRRFSVSTLR NFGLGKKS-- -----LEDWV TKEANHLCDA FTAQAGQP-- 
Cyp2d10               QRRFSVSTLR NFGLGKKS-- -----LEDWV TKEARHLCDA FTAQAGQP-- 
Cyp2d11               QRRFSVSTLR NFGLGKKS-- -----LEEWV TKEARHLCDA FTAQAGQP-- 
Cyp2d12               QRRFSLSSLR NFGLGRKS-- -----LEEWV IKEAGHLCDA FTTQAGQY-- 
Cyp2d13               LRRFSVSTLR NLGLGKKS-- -----LEQWV TEEAGHLCDA FTAQAGSP-- 
Cyp2d22               QRRFSVSTMH HFGLGKKS-- -----LEQWV TEEARCLCAA FADHTGHP-- 
Cyp2d26               QRRFSVSTLR DFGLSKKS-- -----LEQWV TEEAGHLCDA FTKEAEHP-- 
Cyp2e1                VRRFSLSILR DWGMGKQG-- -----NEARI QREAHFLVEE LKKTKGQP-- 
Cyp2f2                LRRFSVQILR NFGMGKRS-- -----IEERI LEEGSFLLEV LRKMEGKP-- 
Cyp2g1                LRRFSLTVLR NFGMGKRS-- -----IEERI QEEAGYLLEE LHKVKGAP-- 
Cyp2j5                QRRLALMALR NFGLGKKS-- -----LEERI QEETHHLVEA IREEGGQP-- 
Cyp2j6                QRRFALMTLR NFGLGKKS-- -----LEERM QEEASHLVEA IREEEGKP-- 
Cyp2j7                QRRFALMILK SFGLGKKS-- -----LEQRI QEEAYHLVKA MEEEKGQP-- 
Cyp2j8                QRRFTLMILK NFGLGKKS-- -----LEQRI QDEAHHLVEA IAEEKGRP-- 
Cyp2j9                QRRFALMTLR NFGLGKRS-- -----LEERI QEEAHYLVEA IRDEGGQP-- 
Cyp2j13               QRRFALMTLR NFGLGKKS-- -----LEHRI QEEASHLVEA IGEEEGQP-- 
Cyp2j12               QRRFALMTLK NFGLGKKS-- -----LEQRI QKEADCLVEA IGEEKGKP-- 
cyp2j11               QRKFALTILK NFGLGKKS-- -----LEQCI QEEAYHLVKA IGEEKGQP-- 
Cyp2r1                HRRLAVNSFH YFGSGQKS-- -----FESKI LEETWSLIDA IETYKGGP-- 
Cyp2s1                LRKFTLLALR DLGMGKRE-- -----GEELI QAEVQSLVEA FQKTEGRP-- 
Cyp2t4                LRNFALGVLR ELGVGRST-- -----IEDRI LEEAACVLDE FQATMGAP-- 
Cyp2U1                QRRFSHSTLR HFGLGKLS-- -----LEPRI IEEFAYVKEA MQKHGEAP-- 
Cyp2w1                GRQFTVRTLQ SLGVQQPS-- -----MVGKV LQELACLKGQ LDSYGGQP-- 
CYP2W1h               ARQFTVRALH SLGVGREP-- -----VADKI LQELKCLSGQ LDGYRGRP-- 
Cyp3a11               YRALLSPTFT SGKLKE---- -----MFPVI EQYGDILVKY LRQKAKKGKP 
Cyp3a13               IRALLSPTFT SGRLKE---- -----MFPII NQFTDVLVRN MRQGLGEGKP 
Cyp3a16               YRALLSPTFT SGNLKE---- -----MFPVI EQYGDILVKY LRQEAEKGKP 
Cyp3a25               LRTLLSPTFT SGKLKE---- -----MFPIM RQYGDILVRN LRREEEKGEP 
Cyp3a57               LRTLLSPTFT SSKLKE---- -----MFPIM RQYGDILVRN LRREEEKEEP 
Cyp3a41               YRALLSPTFT SGKLKE---- -----MFPVI EQYGDILVKY LMQEAEKGKP 
Cyp3a44               YRALLSPTFT SGRLKE---- -----MFPVI EQYGDILVKY LRQEAEKGMP 
Cyp4a10               HRRMLTPAFH YDILKP---- -----YVKNM ADSIRLMLDK WERLADQDSS 
Cyp4a12               HRRMLTPAFH YDILKP---- -----YTEIM ADSVRVMLDK WEQIVGQDST 
Cyp4a14               HRRMLTPAFH YDILKP---- -----YVKIM ADSVNIMLDK WEKLDGQDHP 
Cyp4a30               HRRMLTPAFH YDILKP---- -----YVGIM VDSVHVMLDK WEQLVDQDCP 
Cyp4a29               HRRLLTPAFH YDILKP---- -----YVGIM ADSVQVMLEK WEQIACQDIT 
Cyp4b1                HRKLLTPGFH YDVLKP---- -----YVAIF AESTRVMLDK WEKKASENKS 
Cyp4f13               HRRLLTPAFH FDILKS---- -----YVKIF NKSVNIMHAK WQ-CLASKGT 
Cyp4f14               HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WQ-RLISDGS 
Cyp4f15               HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WQ-HLASGGS 
Cyp4f16               HRRLLTPAFH FDILKP---- -----YVKIF NQSVNIMHAK WK-HLSSEGS 
Cyp4f17               HRHLLTPAFH FDILKP---- -----YMKNF NKSVNIMHAK WQ-RLTTKGT 
Cyp4f18               HRRMLTPAFH FNILKP---- -----YVKVF NDSTNIMHAK WQ-RLASKGS 
Cyp4f37               HRRLLTPAFH FDILKP---- -----YVKIF NQSVNIMHAK WK-HLSSEGS 
Cyp4f39               HRRLLTPAFH FDILKP---- -----YMKIF NQCTNIMHAK WRRHLAEGSV 
Cyp4f40               HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WL-RLASGGS 
Cyp4v3                RRKMLTPTFH FTILEN---- -----FLDVM NEQANILVNK LEKHVNQEAF 
Cyp4x1                HRCLLTPAFH QDILKP---- -----CVDTM AHSVKVMLDK WEKMWTTQET 
Cyp5a1                VRGALMSSFS PEKLDE---- -----MTPLI SQACELLVAH LKRYAASRDA 
Cyp7a1                INKTFNKTLQ GDALCS---- -----LSEAM MQNLQSVMRP PGLPKSKSAV 
Cyp7b1                -VHRAYLLLQ GKPLDA---- -----LLETM IQEVKELFES ---QLLKITD 
Cyp8a1                -R--MKPTLM HRDLQA---- -----LTEAM YTNLRTVLLG --DSTEAGSG 
Cyp8b1                -A--STKHLM GQGLEE---- -----LNQAM LDSLSLVMLG PKGSSLGASS 
Cyp11a1               DRIVLNQEVM APGAIKNFVP ----LLEGVA QDFIKVLHRR IKQQN-SGNF 
Cyp11b1               NRLQLNPNVL SPKAVQKFVP ----LVDGIA RDFVDNLKKK MLESV-HGSF 
Cyp11b2               NRLRLNRNVL SPKAVQKFVP ----MVDMVA RDFLETLKEK VLQNA-RGSL 
Cyp17                 HRKLVFSTFS LFRD-DQK-- -----LEKMI CQEANSLCDL ILTYDGES-- 
Cyp19                 IRPFFMKALT GPGLVR---- -----MVEVC VESIKQHLDR LGEVTDTS-- 
Cyp20                 RRKLYGDAVT ASLHSN---- -----FPLLL QLSEELLDKW LSYPETQHIP 
Cyp21                 HKKLSRSALM LGMR--DS-- -----MEPLI EQLTQEFCER MRAQAGTP-- 
Cyp24                 VRSAFQKKLM KPVEIMKLDK ----KINEVL ADFMGQIDEL RDERG---R- 
Cyp26a1               RKKVIMQAFS REALQC---- -----YVLVI AEEVSSCLEQ WLSCGER--- 
Cyp26b1               KRKVFSKIFS HEALES---- -----YLPKI QLVIQDTLRA WSSQPE---- 
Cyp26c1               RRKVLARVFS RSSLEQ---- -----FVPRL QGALRREVRS WCAAQR---- 
Cyp27a1               LRQALKQRLL KPDEAALYTD ----ALNEVI SDFITRLDQV RAESE-SGDQ 
Cyp27b1               LRSLLAPLLL RPQAAAGYAG ----TLDNVV RDLVRRLRRQ RGRGSGLPGL 
Cyp39                 MKGKMGTFNT HHFTGP---- -----LTEEL HEQLEGLGTH G--------- 
Cyp46                 QRKVMDLAFS RSSLVS---- -----LMETF NEKAEQLVEI LEAKADGQTP 
Cyp51                 QKKIIKSGLN IAHFKQ---- -----YVPII EKEAKEYFQS -------WGE 
CYP1A1h               RRRLAQNGLK SFSIASDPAS STSCYLEEHV SKEAEVLIST LQELMAGPG- 
CYP1A2h               RRRLAQNALN TFSIASDPAS SSSCYLEEHV SKEAKALISR LQELMAGPG- 
CYP1B1h               QRRAAHSMMR NFFTRQPRSR Q---VLEGHV LSEARELVAL LVRGSADGA- 
CYP2A6                LRRFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDA LRGTGGAN-- 
CYP2A7                LLRFAIATLR DFGVGKRG-- -----IEERI QEESGFLIEA IRSTHGAN-- 
CYP2A13               LRRFSIATLR GFGVGKRG-- -----IEERI QEEAGFLIDA LRGTHGAN-- 
CYP2B6                LRRFSVTTMR DFGMGKRS-- -----VEERI QEEAQCLIEE LRKSKGAL-- 
CYP2C8                IRRFSLTNLR NFGMGKRS-- -----IEDRV QEEAHCLVEE LRKTKASP-- 
CYP2C9                IRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTKASP-- 
CYP2C18               IRRFCLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTNASP-- 
CYP2C19               IRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTKASP-- 
CYP2D6                QRRFSVSTLR NLGLGKKS-- -----LEQWV TEEAACLCAA FANHSGRP-- 
CYP2E1h               IRRFSLTTLR NYGMGKQG-- -----NESRI QREAHFLLEA LRKTQGQP-- 
CYP2F1                LRQFSIQILR NFGMGKRS-- -----IEERI LEEGSFLLAD VRKTEGEP-- 
CYP2G2P               LR-FPLTILR DFGMGKRS-- -----IEERI QEEASYLLEE FRKTKGAP-- 
CYP2J2                QRRFTLTALR NFGLGKKS-- -----LEERI QEEAQHLTEA IKEENGQP-- 
CYP2R1h               HRRLAVNSFR YFGYGQKS-- -----FESKI LEETKFFNDA IETYKGRP-- 
CYP2S1h               LRKFTMLALR DLGMGKRE-- -----GEELI QAEARCLVET FQGTEGRP-- 
CYP2T2P               LRNFALGALK KFGLGTRT-- -----VEARV LEEAACLLDE FQATIGAP-- 
CYP2U1h               QRKFSHSTLR HFGLGKLS-- -----LEPKI IEEFKYVKAE MQKHGEDP-- 
CYP3A4                LRSLLSPTFT SGKLKE---- -----MVPII AQYGDVLVRN LRREAETGKP 
CYP3A5                IRSLLSPTFT SGKLKE---- -----MFPII AQYGDVLVRN LRREAEKGKP 
CYP3A7                IRSLLSPTFT SGKLKE---- -----MVPII AQYGDVLVRN LRREAETGKP 
CYP3A43               IRTLLSPAFT SVKFKE---- -----MVPII SQCGDMLVRS LRQEAENSKS 
CYP4A11               HRRMLTPAFH YDILKP---- -----YVGLM ADSVRVMLDK WEELLGQDSP 
CYP4A22               HRRMLTPAFH NDILKP---- -----YVGLM ADSVRVMLDK WEELLGQDSP 
CYP4B1h               HRKLLTPGFH YDVLKP---- -----YVAVF TESTRIMLDK WEEKAREGKS 
CYP4F2                HRRMLTPAFH FNILKP---- -----YMKIF NESVNIMHAK WQ-LLASEGS 
CYP4F3                HRRMLTPAFH FNILKP---- -----YMKIF NESVNIMHAK WQ-LLASEGS 
CYP4F8                HRRLLTPAFH FNILKP---- -----YIKIF SKSANIMHAK WQ-RLAMEGS 
CYP4F11               HRRMLTPAFH FN-LKP---- -----YMKIF NKSVNIMHDK WQ-RLASEGS 
CYP4F12               HRRMLTPAFH FNILKS---- -----YITIF NKSANIMLDK WQ-HLASEGS 
CYP4F22               HRRLLTPAFH FDILKP---- -----YMKIF NQSADIMHAK WR-HLAEGSA 
CYP4F23P              HRHLLTPAFH FKILKP---- -----YVKIF NESTNIMHAK WQ-RLALEGS 
CYP4V2                RRKMLTPTFH FTILED---- -----FLDIM NEQANILVKK LEKHINQEAF 
CYP4X1h               HRRLLTPGFH FNILKA---- -----YIEVM AHSVKMMLDK WEKICSTQDT 
CYP4Z1                HRQIVKPGFN ISILKI---- -----FITMM SESVRMMLNK WEEHIAQNSR 
CYP5A1h               VRGALMSAFS PEKLNE---- -----MVPLI SQACDLLLAH LKRYAESGDA 
CYP7A1h               INDTFIKTLQ GHALNS---- -----LTESM MENLQRIMRP PVSSNSKTAA 
CYP7B1h               -LHLCYQFLQ GKSLDI---- -----LLESM MQNLKQVFEP ---QLLKTTS 
CYP8A1h               -R--MKLTLL HRELQA---- -----LTEAM YTNLHAVLLG --DATEAGSG 
CYP8B1h               -A--STKHLR GDGLKD---- -----LNETM LDSLSFVMLT SKGWSLDASC 
CYP11A1h              DRVALNQEVM APEATKNFLP ----LLDAVS RDFVSVLHRR IKKAG-SGNY 
CYP11B1h              NRLRLNPEVL SPNAVQRFLP ----MVDAVA RDFSQALKKK VLQNA-RGSL 
CYP11B2h              NRLRLNPDVL SPKAVQRFLP ----MVDAVA RDFSQALKKK VLQNA-RGSL 
CYP17h                HRRLAMATFA LFKDGDQK-- -----LEKII CQEISTLCDM LATHNGQS-- 
CYP19h                TRPFFMKALS GPGLVR---- -----MVTVC AESLKTHLDR LEEVTNES-- 
CYP20h                RKKLYENGVT DSLKSN---- -----FALLL KLSEELLDKW LSYPETQHVP 
CYP21A2h              HKKLTRSALL LGIR--DS-- -----MEPVV EQLTQEFCER MRAQPGTP-- 
CYP24h                VRSAFQKKLM KPGEVMKLDN ----KINEVL ADFMGRIDEL CDERG---H- 
CYP26A1h              RKKVIMRAFS REALEC---- -----YVPVI TEEVGSSLEQ WLSCGER--- 
CYP26B1h              KRKVFSKIFS HEALES---- -----YLPKI QLVIQDTLRA WSSHPE---- 
CYP26C1h              RRKVLARVFS RAALER---- -----YVPRL QGALRHEVRS WCAAGG---- 
CYP27A1h              LRQALNQRLL KPAEAALYTD ----AFNEVI DDFMTRLDQL RAESA-SGNQ 
CYP27B1h              LRSLLAPLLL RPQAAARYAG ----TLNNVV CDLVRRLRRQ RGRGTGPPAL 
CYP27C1h              MRSVLRQRIL KPKDVAIYSG ----EVNQVI ADLIKRIYLL RSQAE-DGET 
CYP39A1h              LKGKMGTVNL HQFTGQ---- -----LTEEL HEQLENLGTH G--------- 
CYP46h                QRRVIDLAFS RSSLVS---- -----LMETF NEKAEQLVEI LEAKADGQTP 
CYP51h                QKKMLKSGLN IAHFKQ---- -----HVSII EKETKEYFES -------WGE 

Cyp1a1                H--FDPYKYL VVSVANVICA ICFGQRYDHD DQE---LLSI VNLSNEFGEV 
Cyp1a2                H--FEPVSQV VESVANVIGA MCFGKNFPRK SEE---MLNI VNNSKDFVEN 
Cyp1b1                F--LDPTQPV IVAVANVMSA VCFGCRYNHD DAE---FLEL LSHNEEFGRT 
Cyp2a4                ---IDPTFYL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGSLQF 
Cyp2a5                ---IDPTFYL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGSFQF 
Cyp2a12               ---IDPTIYL SKTASNVISS IVFGDRFNYE DKE---FLSL LQMMGQVNKF 
Cyp2b9                ---LDPTFLF QCITANIICS IVFGERFDYT DDQ---FLHL LNLMYKIFSL 
Cyp2b10               ---LDPTFLF QCITANIICS IVFGERFEYT DRQ---FLRL LELFYQTFSL 
Cyp2b13               ---LDPTFFF QCVTANIICS IVFGERFDYT DEQ---FLRL LNLMYQIYSL 
Cyp2b19               ---LNPTFYF QCIVANIICS IVFGERFDYK DHQ---FLHL LNLIYQTFSL 
Cyp2b23               ---LDPTFLF QCITANIICS IVFGERFDYT DHQ---FLHL LDLFYQTLSL 
Cyp2c29               ---CDPTFIL SCAPCNVICS IIFQNRFDYK DKE---FLIL MDKINENVKI 
Cyp2c37               ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL MEKLNEITKI 
Cyp2c38               ---CDPTFIL SCAPCNVICS IIFQDRFHYK DKD---FLML MKKLNENVKI 
Cyp2c39               ---CDPTFIL SCAPCNVICS IIFQDRFDYK DKD---FLML MEKLNENVKI 
Cyp2c40               ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c44               ---FDPTFIL ACAPCNVICS ILFNERFPYN DKT---FLNL MDLLNKNFYQ 
Cyp2c50               ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL MEKLNEITKI 
Cyp2c54               ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL LEKLDEISKI 
Cyp2c55               ---CDPTFIL SCAPSNVICS VIFHNRFDYK DEK---FLNL MERLNENFKI 
Cyp2c65               ---CDPTFIL GCAPCNVICS IVFQNRFDYK DQE---FLTF LDILNENVEI 
Cyp2c66               ---CDPTFIL GCAPCNVICS IVFQNRFDYK DQE---FLTF IDILNENVEI 
Cyp2c67               ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c68               ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c69               ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c70               ---CDPSFLL ACVPCNVIST VIFQHRFDYN DQT---FQDF MENFHRKIEI 
Cyp2d9                ---INPNPML NKSTCNVIAS LIFARRFEYE DPF---LIRM LKVLEQSLTE 
Cyp2d10               ---INPNTML NNAVCNVIAS LIFARRFEYE DPY---LIRM QKVLEDSLTE 
Cyp2d11               ---INPNPML NKSTCNVIAS LIFARRFEYE DPF---LIRM LKMLKECFTE 
Cyp2d12               ---INPNTML KKATCNVIAS LIFARRFEYE DPY---LIRM LKVLEDSLTE 
Cyp2d13               ---LDPYTLL NKAVCNVIAS LIYARRFEYG DPD---FIKM LKILKENMGE 
Cyp2d22               ---FSPNTLL DKAVCNVIAS LLYACRFEYD DPR---FIRL LGLLKETLKE 
Cyp2d26               ---FNPSPLL SKAVSNVIAS LIYARRFEYE DPF---FNRM LKTLKESLGE 
Cyp2e1                ---FDPTFLI GCAPCNVIAD ILFNKRFDYD DKK---CLEL MSLFNENFYL 
Cyp2f2                ---FDPVFIL SRSVSNIICS VVFGSRFDYD DER---LLTI XHFINDNFKI 
Cyp2g1                ---IDPTLYL SRTVSNVICS VVFGKRFDYQ DQR---FQSL MRMINESFVE 
Cyp2j5                ---FNPHLKL INAVSNIICS VTFGERFDYE DCQ---FQEL LQLLDETMHL 
Cyp2j6                ---FNPHFSI NNAVSNIICS VTFGERFDYH DSR---FQEM LRLLDEVMYL 
Cyp2j7                ---FDPHFRI NSAVSNIICS INFGERFEYG DNK---FQEL LKITNETLSA 
Cyp2j8                ---FDPHFMI NNAVSNIICS ITIGERFEYE DNQ---FQEL LKLADETLCL 
Cyp2j9                ---FDPHFNI SNAVSNIICS ITFGERFDYH DSQ---FQEM LRLLDEAMCL 
Cyp2j13               ---FDPHFKI YSAVSNIICS ITFGERFEYH DSQ---FQEL LQLLDKAMYL 
Cyp2j12               ---FDPHFKI NSAVSNIICT FAFGERFEYE DSH---FHEL LRLLDEATCL 
cyp2j11               ---FDPHFRI NNAVGNIICS IIFGERFEYD DNQ---FQEL LKLADEIICS 
Cyp2r1                ---FDLKQLI TNAVSNITNL ILFGERFTYE DTD---FQHM IELFSENVEL 
Cyp2s1                ---FNPSMLL AQATSNVVCS LVFGIRLPYD DKE---FQAV IQAASGTLLG 
Cyp2t4                ---FDPQQLL DSAVSNVICT VVFGKRYDYG DPE---FRRL LNLFSDNFCI 
Cyp2U1                ---FSPFPII SNAVSNIICS LCFGQRFDYT NKE---FKKV LDFMSRGLEI 
Cyp2w1                ---LP-LALL GWAPCNITFT LLFGQRFDYQ DPV---FVSL LSLIDQVMVL 
CYP2W1h               ---FP-LALL GWAPSNITFA LLFGRRFDYR DPV---FVSL LGLIDEVMVL 
Cyp3a11               ---VTMKDVL GAYSMDVITS TSFGVNVDSL NNP------- ----EDPFVE 
Cyp3a13               ---TSMKDIF GAYSMDVITA TSFGVNIDSL NNP------- ----QDPFVE 
Cyp3a16               ---VAVKDVL GAYSMDVIIS TTFGVNIDSL NNP------- ----EDPFVE 
Cyp3a25               ---ISMKDIF GAYSMDVITG TSFGVNVDSL NNP------- ----QDPFVQ 
Cyp3a57               ---INMKDIF GAYSMDVITG TSCGVNIDSL NNP------- ----QDPFVQ 
Cyp3a41               ---VTMKDVL GAYSIDVITS TSFGVNVDSL NNP------- ----EDPFVE 
Cyp3a44               ---VAMKDVL GAYSMDVITS TSFGVNVDSL NNP------- ----EDPFVE 
Cyp4a10               ---IEIFQHI SLMTLDTVMK CAFSHKGSVQ VDG--NYRTY LQAIGDLNNL 
Cyp4a12               ---LEIFRHI TLMTLDTIMK CAFSHEGSVQ LDR--KYKSY IQAVEDLNDL 
Cyp4a14               ---LEIFHCV SLMTLDTVMK CAFSYQGSVQ LDE--NSKLY TKAVEDLNNL 
Cyp4a30               ---LEIYQDI SLMTMETMMK CAFSYQGSVQ LE---NSKSY IKAVEDLTHL 
Cyp4a29               ---LEIFHPI SLMMLDTIMK YAFSYQGSVQ LDRSRSSQAY LQAVSDLNNL 
Cyp4b1                ---FDIFCDV GHMALDTLMK CTFGKGDSGL SHS---DNSY YLAVSDLTLL 
Cyp4f13               S-RLDMFEHI SLMTLDSLQK CIFSVDSNCQ ESD----SKY IAAILELSSL 
Cyp4f14               A-RLDMFEHV SLMTLDSLQK CVFSFDSNCQ EKS----SEY IAAILELSAL 
Cyp4f15               A-RLDVFENI SLMTLDSLQK CVFSFDSNCQ ENP----SEY ISAILELSAL 
Cyp4f16               A-RLEMFEHI SLMTLDSLQK CLFGFDSNCQ ESP----SEY ISAILELSSL 
Cyp4f17               A-CLDMLEHI SLMTLDSLQN CVFSFDSNCQ ESP----SEY IAAIQELSSL 
Cyp4f18               A-YLNMFEHI SLMTLDSLQK CVFSFDSNCQ EKP----SEY ITAILELSAL 
Cyp4f37               A-RLEMFEHI SLMTLDSLQK CLFGFDSNCQ ESP----SEY ISAILELSSL 
Cyp4f39               T-SFDMFEHI SLMTLDSLQK CVFSYNSDCQ ESM----SDY ISSIIELSAL 
Cyp4f40               T-RLNMFENI SLMTLDTLQK CVFSFNSNCQ EKP----SQY IAAILELSTL 
Cyp4v3                N----CFFYI TLCALDIICE TAMGKNIGAQ SNN---DSEY VRTVYRMSDM 
Cyp4x1                T--IEVFEHI NLMTLDIIMK CAFGQETNCQ INS--TYESY VKATFELGEI 
Cyp5a1                F-NIQRCYC- -CYTIDVVAS VAFGTQVDSQ NSP------- ----EDPFVQ 
Cyp7a1                WVTEGMYAFC YRVMFEAGYL TLFGKDISK- ---------- --TDTQRAFI 
Cyp7b1                WNTERIFAFC GSLVFEITFA TLYGKILAG- ---------- --NKKQ--II 
Cyp8a1                WQETGLLEFS YNALLSAGYL TLYGVEASPR THE------- S-QAQDRVHS 
Cyp8b1                WCEDGLFHFC YRILFKAGFL SLFGYTKD-- ---------- --KQQDLDEA 
Cyp11a1               S--GVISDDL FRFSFESISS VIFGERMGML EEI---VDPE AQRFINAVY- 
Cyp11b1               S--MDFQSSV FNYTIEASHF VLFGERLGLI GRD---LSPD SLKFLHTLH- 
Cyp11b2               T--MDVQQSL FNYTIEASNF ALFGERLGLL GHD---LSPG SLKFIHALH- 
Cyp17                 ---RDLSTLI FKSVINIICT ICFNISFENK DPI---LTTI QTFTEGIVDV 
Cyp19                 ---GYVDVLT LMRHIMLDTS NMLFLGIPLD ESA---IVKK IQGYFNAWQA 
Cyp20                 ---LS-QHML GFALKFVTRM VLG----STF EDE----QEV IRFQKIHGTV 
Cyp21                 ---VAIHKEF SFLTCSIISC LTFGD---KD STL---VQTL HDCVQDLLQA 
Cyp24                 I--QDLYSEL NKWSFESICL VLYEKRFGLL QKD---TEEE ALTFIAAIK- 
Cyp26a1               --GLLVYPEV KRLMFRIAMR ILLGCEPGPA G--------- --GGEDEQQL 
Cyp26b1               --AINVYQEA QRLTFRMAVR VLLGFSIPEE ---------- -----DLGHL 
Cyp26c1               --PVAVYQAA KALTFRMAAR ILLGLQLDEA ---------- -----RCTEL 
Cyp27a1               V--PDMAHLL YHLALEAITY ILFEKRIGCL KPS---IPED TAAFIRSVA- 
Cyp27b1               V--LDVAGEF YKFGLESIGA VLLGSRLGCL EAE---VPPD TETFIHAVG- 
Cyp39                 --TMDLNDFV RYLLYPATLN TLFKKGLFLT ---------- --DKRTIKEF 
Cyp46                 ---VSMQDML TCATIDILAK AAFGMETSML LGA----QKP LSQAVKVMLE 
Cyp51                 SGERNVFEAL SELIILTASH CLHGKEIRS- --Q------- L-NEKVAQLY 
CYP1A1h               H--FNPYRYV VVSVTNVICA ICFGRRYDHN HQE---LLSL VNLNNNFGEV 
CYP1A2h               H--FDPYNQV VVSVANVIGA MCFGQHFPES SDE---MLSL VKNTHEFVET 
CYP1B1h               F--LDPRPLT VVAVANVMSA VCFGCRYSHD DPE---FREL LSHNEEFGRT 
CYP2A6                ---IDPTFFL SRTVSNVISS IVFGDRFDYK DKE---FLSL LRMMLGIFQF 
CYP2A7                ---IDPTFFL SRTVSNVISS IVFGDRFDYE DKE---FLSL LSMMLGIFQF 
CYP2A13               ---IDPTFFL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGRFQF 
CYP2B6                ---MDPTFLF QSITANIICS IVFGKRFHYQ DQE---FLKM LNLFYQTFSL 
CYP2C8                ---CDPTFIL GCAPCNVICS VVFQKRFDYK DQN---FLTL MKRFNENFRI 
CYP2C9                ---CDPTFIL GCAPCNVICS IIFHKRFDYK DQQ---FLNL MEKLNENIKI 
CYP2C18               ---CDPTFIL GCAPCNVICS VIFHDRFDYK DQR---FLNL MEKFNENLRI 
CYP2C19               ---CDPTFIL GCAPCNVICS IIFQKRFDYK DQQ---FLNL MEKLNENIRI 
CYP2D6                ---FRPNGLL DKAVSNVIAS LTCGRRFEYD DPR---FLRL LDLAQEGLKE 
CYP2E1h               ---FDPTFLI GCAPCNVIAD ILFRKHFDYN DEK---FLRL MYLFNENFHL 
CYP2F1                ---FDPTFVL SRSVSNIICS VLFGSRFDYD DER---LLTI IRLINDNFQI 
CYP2G2P               ---IDPIFLL SRTVSNVISS VVFRSRFDYE DKQ---FLNL LRLINESFIE 
CYP2J2                ---FDPHFKI NNAVSNIICS ITFGERFEYQ DSW---FQQL LKLLDEVTYL 
CYP2R1h               ---FDFKQLI TNAVSNITNL IIFGERFTYE DTD---FQHM IELFSENVEL 
CYP2S1h               ---FDPSLLL AQATSNVVCS LLFGLRFSYE DKE---FQAV VRAAGGTLLG 
CYP2T2P               ---FDPVRLL DNAVSNVICS LVFGNRYRYG DPE---FLRL LNLFSDNFCI 
CYP2U1h               ---FCPFSII SNAVSNIICS LCFGQRFDYT NSE---FKKM LGFMSRGLEI 
CYP3A4                V-TLKDVFG- -AYSMDVITS TSFGVNIDSL NNP------- ----QDPFVE 
CYP3A5                V-TLKDIFG- -AYSMDVITG TSFGVNIDSL NNP------- ----QDPFVE 
CYP3A7                V-TLKHVFG- -AYSMDVITS TSFGVSIDSL NNP------- ----QDPFVE 
CYP3A43               I-NLKEDFFG -AYTMDVITG TLFGVNLDSL NNP------- ----QDPFLK 
CYP4A11               ---LEVFQHV SLMTLDTIMK CAFSHQGSIQ VDR--NSQSY IQAISDLNNL 
CYP4A22               ---LEVFQHV SLMTLDTIMK SAFSHQGSIQ VDR--NSQSY IQAISDLNSL 
CYP4B1h               ---FDIFCDV GHMALNTLMK CTFGRGDTGL GHR---DSSY YLAVSDLTLL 
CYP4F2                A-CLDMFEHI SLMTLDSLQK CVFSFDSHCQ EKP----SEY IAAILELSAL 
CYP4F3                A-RLDMFEHI SLMTLDSLQK CVFSFDSHCQ EKP----SEY IAAILELSAL 
CYP4F8                T-CLDVFEHI SLMTLDSLQK CIFSFDSNCQ EKP----SEY ITAIMELSAL 
CYP4F11               A-RLDMFEHI SLMTLDSLQK CVFSFESNCQ EKP----SEY IAAILELSAF 
CYP4F12               S-RLDMFEHI SLMTLDSLQK CIFSFDSHCQ ERP----SEY IATILELSAL 
CYP4F22               V-SLDMFEHI SLMTLDSLQK CVFSYNSNCQ EKM----SDY ISAIIELSAL 
CYP4F23P              V-RLEMFEHI SLMTLDSLQK CIFSFDSNCQ EKP----SEY IDAILELSAL 
CYP4V2                N----CFFYI TLCALDIICE TAMGKNIGAQ SND---DSEY VRAVYRMSEM 
CYP4X1h               S--VEVYEHI NSMSLDIIMK CAFSKETNCQ TNS--THDPY AKAIFELSKI 
CYP4Z1                ---LELFQHV SLMTLDSIMK CAFSHQGSIQ LD----RSSY LKAVFNLSKI 
CYP5A1h               F-DIQRCYC- -NYTTDVVAS VPFGTPVDSW QAP------- ----EDPFVK 
CYP7A1h               WVTEGMYSFC YRVMFEAGYL TIFGRDLTR- ---------- --RDTQKAHI 
CYP7B1h               WDTAELYPFC SSIIFEITFT TIYGKVIVC- ---------- --DNNK--FI 
CYP8A1h               WHEMGLLDFS YSFLLRAGYL TLYGIEALPR THE------- S-QAQDRVHS 
CYP8B1h               WHEDSLFRFC YYILFTAGYL SLFGYTKD-- ---------- --KEQDLLQA 
CYP11A1h              S--GDISDDL FRFAFESITN VIFGERQGML EEV---VNPE AQRFIDAIY- 
CYP11B1h              T--LDVQPSI FHYTIEASNL ALFGERLGLV GHS---PSSA SLNFLHALE- 
CYP11B2h              T--LDVQPSI FHYTIEASNL ALFGERLGLV GHS---PSSA SLNFLHALE- 
CYP17h                ---IDISFPV FVAVTNVISL ICFNTSYKNG DPE---LNVI QNYNEGIIDN 
CYP19h                ---GYVDVLT LLRRVMLDTS NTLFLRIPLD ESA---IVVK IQGYFDAWQA 
CYP20h                ---LS-QHML GFAMKSVTQM VMG----STF EDD----QEV IRFQKNHGTV 
CYP21A2h              ---VAIEEEF SLLTCSIICY LTFGDKI-KD DNL---MPAY YKCIQEVLKT 
CYP24h                V--EDLYSEL NKWSFESICL VLYEKRFGLL QKN---AGDE AVNFIMAIK- 
CYP26A1h              --GLLVYPEV KRLMFRIAMR ILLGCEPQLA G--------- --DGDSEQQL 
CYP26B1h              --AINVYQEA QKLTFRMAIR VLLGFSIPEE ---------- -----DLGHL 
CYP26C1h              --PVSVYDAS KALTFRMAAR ILLGLRLDEA ---------- -----QCATL 
CYP27A1h              V--SDMAQLF YYFALEAICY ILFEKRIGCL QRS---IPED TVTFVRSIG- 
CYP27B1h              V--RDVAGEF YKFGLEGIAA VLLGSRLGCL EAQ---VPPD TETFIRAVG- 
CYP27C1h              V--TNVNDLF FKYSMEGVAT ILYESRLGCL ENS---IPQL TVEYIEALEL 
CYP39A1h              --TMDLNNLV RHLLYPVTVN MLFNKSLFST ---------- --NKKKIKEF 
CYP46h                ---VSMQDML TYTAMDILAK AAFGMETSML LGA----QKP LSQAVKLMLE 
CYP51h                SGEKNVFEAL SELIILTASH CLHGKEIRS- --Q------- L-NEKVAQLY 

Cyp1a1                T-GS---GYP ADFIP----- VLRYLPNSS- ---------- -----LDAFK 
Cyp1a2                V-TS---GNA VDFFP----- VLRYLPNPA- ---------- -----LKRFK 
Cyp1b1                V-GA---GSL VDVLP----- WLQLFPNPVR TT-------- -----FRKFE 
Cyp2a4                T-AT-SMGQV YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
Cyp2a5                T-AT-SMGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
Cyp2a12               A-AS-PTGQL YDMFH----S VMKYLPGP-- ---------- -----QQQII 
Cyp2b9                L-SS-FSGQM FELFS----G FLKYFPGV-- ---------- -----HRQIV 
Cyp2b10               I-SS-FSSQM FELFS----G FLKYFPGA-- ---------- -----HRQIS 
Cyp2b13               L-RS-FSCQM FELFS----G LLKYFPGV-- ---------- -----HRQIA 
Cyp2b19               M-SS-LSSQV FELFS----A ILKYFPGA-- ---------- -----HRQIS 
Cyp2b23               I-SS-FSSQL FELFS----A VMKYFPGT-- ---------- -----HRQIS 
Cyp2c29               L-SS-PWLQV CNSFPS---- LIDYCPGS-- ---------- -----HHKIV 
Cyp2c37               L-SS-PWLQI CNTYPA---- LLDYCPGS-- ---------- -----HKQFF 
Cyp2c38               L-SS-PWLQV CNNFPL---- LIDYCPGS-- ---------- -----HHKVL 
Cyp2c39               L-SS-PWLQV CNNFPL---- LIDYCPGS-- ---------- -----HHKVL 
Cyp2c40               L-SS-PGCQI FNAVPI---- LIDYCPGS-- ---------- -----HNKLF 
Cyp2c44               L-NS-IWIQM YNLWPT---- IMKYIPGK-- ---------- -----HREFS 
Cyp2c50               M-ST-PWLQV CNTFPV---- LLDYCPGS-- ---------- -----HNKVF 
Cyp2c54               L-ST-PWLQV CNTFPA---- LLDYCPGS-- ---------- -----HNQFF 
Cyp2c55               L-NS-PWMQV YNALPT---- LINYLPGS-- ---------- -----HNKVI 
Cyp2c65               L-SS-PWIQI CNNFPA---- VIDYLPGR-- ---------- -----HRKLH 
Cyp2c66               L-SS-PWIQV CNNFPA---- IIDYLPGR-- ---------- -----HRKLL 
Cyp2c67               L-SS-PGCQI FNAVPI---- LIDYCPGR-- ---------- -----HNKFF 
Cyp2c68               L-SS-PECQI FNAVPI---- LIDYCPGS-- ---------- -----HNKFL 
Cyp2c69               L-SS-PGCQI FNAVPI---- LIDYCPGR-- ---------- -----HNKFF 
Cyp2c70               L-AS-PWSQL CSAYP----- ILYYLPGI-- ---------- -----HNRFL 
Cyp2d9                V-SG-LIPEV LNAFP----I LLRIP-RL-- ---------- -----ADKAL 
Cyp2d10               I-SL-AYSEV LNMFP----I LLRIP-GL-- ---------- -----PGKVF 
Cyp2d11               I-SG-FIPGV LNEFP----I FLRIP-GL-- ---------- -----ADMVF 
Cyp2d12               L-SG-LIPEV INTFP----I LLHIP-RL-- ---------- -----ADKFL 
Cyp2d13               N-TG-LFPEV LNTFP----I LLHIP-GL-- ---------- -----ADKVF 
Cyp2d22               E-AG-FLPMF LNVFP----M LLRIP-GL-- ---------- -----VGKVF 
Cyp2d26               D-TG-FVGEV LNAIP----M LLHIP-GL-- ---------- -----PDKAF 
Cyp2e1                L-ST-PWIQA YNYFS----D YLQYLPGS-- ---------- -----HRKVM 
Cyp2f2                M-SS-PWGEM YNIFP----S VLDWIPGP-- ---------- -----HKRLF 
Cyp2g1                M-SK-PWAQL YDMYW----K VMQYFPGR-- ---------- -----HNYLY 
Cyp2j5                M-GS-SAGQL YNGFP----C IMKYLPGP-- ---------- -----HQKIF 
Cyp2j6                E-TT-MISQL YNIFP----W IMKYIPGS-- ---------- -----HQKVF 
Cyp2j7                E-TS-MMLVL YNALP----S IMKYLPGP-- ---------- -----HQTVF 
Cyp2j8                E-AS-KVLML YNVFP----S IFKYLPGP-- ---------- -----HQKLF 
Cyp2j9                E-SS-MMCQL YNIFP----R ILQYLPGS-- ---------- -----HQTLF 
Cyp2j13               G-TTSLMVHL YNIFP----W ITKHLPGQ-- ---------- -----HQTLL 
Cyp2j12               E-AS-MMCQL YNVFP----S IIQYVPGS-- ---------- -----HQTVL 
cyp2j11               E-AS-MMSVL YNVFP----S IFKYLPGP-- ---------- -----QQKLF 
Cyp2r1                A-AS-APVFL YNAFP----W IGILPFGK-- ---------- -----HQRLF 
Cyp2s1                I-SS-PWGQA YEMFS----W LLQPLPGP-- ---------- -----HTQLQ 
Cyp2t4                M-SS-RWAEI YNMFP----S FMDWIPGP-- ---------- -----HNRIF 
Cyp2U1                C-LH-SQLFL INICP----W FYYLPFGP-- ---------- -----FKELR 
Cyp2w1                L-GS-PGIQL FNTFP----R LGAFLRL--- ---------- -----HRPVL 
CYP2W1h               L-GS-PGLQL FNVYP----W LGALLQL--- ---------- -----HRPVL 
Cyp3a11               KAKKLLRFDF FDPL----LF SVVLFP---- ---------- -------FLT 
Cyp3a13               KIKKLLKFDI FDPL----FL SVTLFP---- ---------- -------FLT 
Cyp3a16               NAKKVLRFDY FDPL----SL SVALFP---- ---------- -------FLT 
Cyp3a25               KAKKILKFKV FDPF----LL SIILFP---- ---------- -------FLT 
Cyp3a57               KIKKILKFKF FDPF----LL SVVLFP---- ---------- -------FLT 
Cyp3a41               KAKGILRVDF FDPL----VF SVVLFP---- ---------- -------FLT 
Cyp3a44               EAKKFLRVDF FDPL----LF SVVLFP---- ---------- -------LLT 
Cyp4a10               FHSRVRNIFH QNDT----IY KLS------- ---------- ---SNGRLAK 
Cyp4a12               VFSRVRNIFH QNDI----IY RVS------- ---------- ---SNGCKAN 
Cyp4a14               TFFRLRNAFY KYNI----IY NMS------- ---------- ---SDGRLSH 
Cyp4a30               IYLRVRNGFH QNNT----IY SLSSFRA--M ES-------- HIFTNGRSFY 
Cyp4a29               VTSRMKNVFL HNDI----IY NLT------- ---------- ---SHSRRTN 
Cyp4b1                MQQRIDSFQY HNDF----IY WLTP------ ---------- ----HGRRFL 
Cyp4f13               VVKRHRQPFL YLDL----LY YLTA------ ---------- ----DGRRFR 
Cyp4f14               VAKRHQQPLM FMDL----LY NLTP------ ---------- ----DGMRFR 
Cyp4f15               VTKRYHQLLL HIDS----LY QLTC------ ---------- ----SGRRFH 
Cyp4f16               IIKRSLQLFL FVDF----LY YHTA------ ---------- ----DGRRFR 
Cyp4f17               IVKRHHQPFL YLDF----LY YCTA------ ---------- ----DGRRFR 
Cyp4f18               VARRHQRLLL HVDL----FY YLTH------ ---------- ----DGMRFR 
Cyp4f37               VIKRSHQLFL FVDF----LY YHTA------ ---------- ----DGRRFR 
Cyp4f39               VVRRQYRLHH YLDF----MY YLTA------ ---------- ----DGRRFR 
Cyp4f40               AVKRNEQLLM HVDL----LY RLTP------ ---------- ----DGMRFY 
Cyp4v3                IYRRMKMPWL WFDL----WY LVFK------ ---------- ----EGRDHK 
Cyp4x1                ISSRLYNFWH HHDI----IF KLS------- ---------- ---PKGHCFQ 
Cyp5a1                HCRRASTFCI PRPL----LV LILSFP---- ---------- -------SIM 
Cyp7a1                QNNLDSFKQF DQVFP----- ---------- ---------- -----ALVAG 
Cyp7b1                SELRDDFFKF DDMFP----- ---------- ---------- -----YLVSD 
Cyp8a1                ADVFHTFRQL DLLLP----- ---------- ---------- -----KLARG 
Cyp8b1                DELFRKFRRF DFLFP----- ---------- ---------- -----RFVYS 
Cyp11a1               --QMFHTSVP MLNLP---PD FFRLLRTK-- ---------- ----TWKDHA 
Cyp11b1               --SMFKTTTQ LLYLP---RS LTRWTSTR-- ---------- ----VWKENL 
Cyp11b2               --SMFKSTSQ LLFLP---KS LTRWTSTR-- ---------- ----VWKEHF 
Cyp17                 L-GHS---DL VDIFP----- WLKIFPNKN- ---------- -----LEMIK 
Cyp19                 LLIK---PNI FFKIS----W LYRKYERS-- ---------- -----VKDLK 
Cyp20                 WSEIGKGFLD GSLD----KN TTR------- ---------- ----K-KQYQ 
Cyp21                 W-NHWS-IQI LTIIP----- LLRFLPNPG- ---------- -----LQKLK 
Cyp24                 --TMMSTFGK MMVTP---VE LHKRLNTK-- ---------- ----VWQAHT 
Cyp26a1               VEAFEEMTRN LFSLPI---- ---------- ---------- -----DVPFS 
Cyp26b1               FEVYQQFVEN VFSLPV---- ---------- ---------- -----DLPFS 
Cyp26c1               AHTFEQLVEN LFSLPL---- ---------- ---------- -----DVPFS 
Cyp27a1               --IMFQNSVY ITFLP---KW TRPLLP---- ---------- ----FWKRYL 
Cyp27b1               --SVFVSTLL TMAMP---NW LHHLIPG--- ---------- ----PWARLC 
Cyp39                 YQQFKTYDEG FEYGS----- ---------- ---------- -----QLPEW 
Cyp46                 GISASRNTLA KFMP----GK RKQ------- ---------- ----L-REIR 
Cyp51                 ADLDGGFTHA AWLLPA---- ---------- ---------- -----WLPLP 
CYP1A1h               V-GS---GNP ADFIP----- ILRYLPNPS- ---------- -----LNAFK 
CYP1A2h               A-SS---GNP LDFFP----- ILRYLPNPA- ---------- -----LQRFK 
CYP1B1h               V-GA---GSL VDVMP----- WLQYFPNPVR TV-------- -----FREFE 
CYP2A6                T-ST-STGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
CYP2A7                T-ST-STGQL YEMFS----S LMKHLPGP-- ---------- -----QQQAF 
CYP2A13               T-GT-STGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
CYP2B6                I-SS-VFGQL FELFS----G FLKYFPGA-- ---------- -----HRQVY 
CYP2C8                L-NS-PWIQV CNNFPL---- LIDCFPGT-- ---------- -----HNKVL 
CYP2C9                L-SS-PWIQI CNNFSP---- IIDYFPGT-- ---------- -----HNKLL 
CYP2C18               L-SS-PWIQV CNNFPA---- LIDYLPGS-- ---------- -----HNKIA 
CYP2C19               V-ST-PWIQI CNNFPT---- IIDYFPGT-- ---------- -----HNKLL 
CYP2D6                E-SG-FLREV LNAVP----V LLHIP-AL-- ---------- -----AGKVL 
CYP2E1h               L-ST-PWLQL YNNFPS---- FLHYLPGS-- ---------- -----HRKVI 
CYP2F1                M-SS-PWGEL YDILDPRFPS LLDWVPGP-- ---------- -----HQRIF 
CYP2G2P               M-ST-PWAQL YDMYS----G IMQYLPGR-- ---------- -----HNLIY 
CYP2J2                E-AS-KTCQL YNVFP----W IMKFLPGP-- ---------- -----HQTLF 
CYP2R1h               A-AS-ASVFL YNAFP----W IGILPFGK-- ---------- -----HQQLF 
CYP2S1h               V-SS-QGGQT YEMFS----W FLRPLPGP-- ---------- -----HKQLL 
CYP2T2P               I-SS-RWGES ---------- LMDWLPGP-- ---------- -----HHRIF 
CYP2U1h               C-LN-SQVLL VNICP----W LYYLPFGP-- ---------- -----FKELR 
CYP3A4                NTKKLLRFDF LDPF----FL SIIFP----- ---------- -------FLI 
CYP3A5                STKKFLKFGF LDPL----FL SIILFP---- ---------- -------FLT 
CYP3A7                NTKKLLRFNP LDPF----VL SIKVFP---- ---------- -------FLT 
CYP3A43               NMKKLLKLDF LDPF----LL LISLFP---- ---------- -------FLT 
CYP4A11               VFSRVRNAFH QNDT----IY SLT------- ---------- ---SAGRWTH 
CYP4A22               VFCCMRNAFH ENDT----IY SLT------- ---------- ---SAGRWTH 
CYP4B1h               MQQRLVSFQY HNDF----IY WLTP------ ---------- ----HGRRFL 
CYP4F2                VSKRHHEILL HIDF----LY YLTP------ ---------- ----DGQRFR 
CYP4F3                VTKRHQQILL YIDF----LY YLTP------ ---------- ----DGQRFR 
CYP4F8                VVKRNNQFFR YKDF----LY FLTP------ ---------- ----CGRRFH 
CYP4F11               VEKRNQQILL HTDF----LY YLTP------ ---------- ----DGQRFR 
CYP4F12               VEKRSQHILQ HMDF----LY YLSH------ ---------- ----DGRRFH 
CYP4F22               SVRRQYRLHH YLDF----IY YRSA------ ---------- ----DGRRFR 
CYP4F23P              SLKRHQHIFL LTDF----LY FLTP------ ---------- ----NGRRFC 
CYP4V2                IFRRIKMPWL WLDL----WY LMFK------ ---------- ----EGWEHK 
CYP4X1h               IFHRLYSLLY HSDI----IF KLS------- ---------- ---PQGYRFQ 
CYP4Z1                SNQRMNNFLH HNDL----VF KFS------- ---------- ---SQGQIFS 
CYP5A1h               HCKRFFEFCI PRPI----LV LLLSFP---- ---------- -------SIM 
CYP7A1h               LNNLDNFKQF DKVFP----- ---------- ---------- -----ALVAG 
CYP7B1h               SELRDDFLKF DDKFA----- ---------- ---------- -----YLVSN 
CYP8A1h               ADVFHTFRQL DRLLP----- ---------- ---------- -----KLARG 
CYP8B1h               GELFMEFRKF DLLFP----- ---------- ---------- -----RFVYS 
CYP11A1h              --QMFHTSVP MLNLP---PD LFRLFRTK-- ---------- ----TWKDHV 
CYP11B1h              --VMFKSTVQ LMFMP---RS LSRWTSPK-- ---------- ----VWKEHF 
CYP11B2h              --VMFKSTVQ LMFMP---RS LSRWISPK-- ---------- ----VWKEHF 
CYP17h                L-SKD---SL VDLVP----- WLKIFPNKT- ---------- -----LEKLK 
CYP19h                LLIK---PDI FFKIS----W LYKKYEKS-- ---------- -----VKDLK 
CYP20h                WSEIGKGFLD GSLD----KN MTR------- ---------- ----K-KQYE 
CYP21A2h              W-SHWS-IQI VDVIP----- FLRFFPNPG- ---------- -----LRRLK 
CYP24h                --TMMSTFGR MMVTP---VE LHKSLNTK-- ---------- ----VWQGHT 
CYP26A1h              VEAFEEMTRN LFSLPI---- ---------- ---------- -----DVPFS 
CYP26B1h              FEVYQQFVDN VFSLPV---- ---------- ---------- -----DLPFS 
CYP26C1h              ARTFEQLVEN LFSLPL---- ---------- ---------- -----DVPFS 
CYP27A1h              --LMFQNSLY ATFLP---KW TRPVLP---- ---------- ----FWKRYL 
CYP27B1h              --SVFVSTLL TMAMP---HW LRHLVPG--- ---------- ----PWGRLC 
CYP27C1h              MFSMFKTSMY AGAIP---RW LRPFIPK--- ---------- ----PWREFC 
CYP39A1h              HQYFQVYDED FEYGS----- ---------- ---------- -----QLPEC 
CYP46h                GITASRNTLA KFLP----GK RKQ------- ---------- ----L-REVR 
CYP51h                ADLDGGFSHA AWLLPG---- ---------- ---------- -----WLPLP 

Cyp1a1                DLNDKFYSFM K--KLIKEHY RTFEK-GH-- ---------- --IRDITDSL 
Cyp1a2                TFNDNFVLFL Q--KTVQEHY QDFNK-NS-- ---------- --IQDITSAL 
Cyp1b1                QLNRNFSNFV L--DKFLRHR ESLVPGAA-- ---------- --PRDMTDAF 
Cyp2a4                KELQGLEDFI T--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
Cyp2a5                KELQGLEDFI T--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
Cyp2a12               KDSHKLEDFM I--QKVKQNQ STLDPN-S-- ---------- --PRDFIDSF 
Cyp2b9                KKQQELLDYI A--HSVEKHK ATLDPS-A-- ---------- --PRDYIDTY 
Cyp2b10               KNLQELLDYI G--HSVEKHR ATLDPS-V-- ---------- --PRDFIDIY 
Cyp2b13               KNQQEILNFI T--HRVEKHR ASLDPS-E-- ---------- --PRDFIDTY 
Cyp2b19               KNLQEILDYI G--HSVEKHR ATLDPS-A-- ---------- --PRDFIDTY 
Cyp2b23               KNIQEILNYI G--HSVEQHK ATLDPS-A-- ---------- --PRDFIDTY 
Cyp2c29               KNFNYLKSYL L--EKIKEHK ESLDVT-N-- ---------- --PRDFIDYY 
Cyp2c37               KNYACIKNFL L--EKIKEHE ESLDVT-I-- ---------- --PRDFIDYF 
Cyp2c38               KNFKYIRSYL L--EKVKEHQ ASLDFT-N-- ---------- --PRDFIDYF 
Cyp2c39               KNVKYIRSYL L--EKIKEHQ ESLDVT-N-- ---------- --PRDFIDYY 
Cyp2c40               KNHTWIKSYL L--GKIKEHE ESLDVT-N-- ---------- --PRDFIDYF 
Cyp2c44               KRLGGVKNFI L--EKVKEHQ EFLDPA-N-- ---------- --PRDYIDCF 
Cyp2c50               KNYACIKNFL L--EKIKEHE ESLDVT-I-- ---------- --PRDFIDYF 
Cyp2c54               KNYAYIKNFL L--EKIREHK ESLDVT-I-- ---------- --PRDFIDYF 
Cyp2c55               KNFTEIKSYI L--GRVKEHQ ETLDMD-N-- ---------- --PRDFIDCF 
Cyp2c65               KNFAFAEHYF L--SKVKQHQ ESLDIN-N-- ---------- --PRDFIDCF 
Cyp2c66               KNFDFAKHYF L--AKVIQHK ESLDIN-N-- ---------- --PRDFIDCF 
Cyp2c67               KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFIDYF 
Cyp2c68               KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFVDYF 
Cyp2c69               KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFIDYF 
Cyp2c70               KDVTQQKKFI L--EEINRHQ KSLDLS-N-- ---------- --PQDFIDYF 
Cyp2d9                QGQKSFIAIL D--NLLTENR TTWDPVQA-- ---------- --PRNLTDAF 
Cyp2d10               QGQKSLLAIV E--NLLTENR NTWDPDQP-- ---------- --PRNLTDAF 
Cyp2d11               QGQKSFMAIL D--NLLTENR TTWDPDQP-- ---------- --PRNLTDAF 
Cyp2d12               QSQKSFIAIV D--NLLTENR TTWDPAQS-- ---------- --PRNLTDAF 
Cyp2d13               PGQKTFLTLV N--KLVTEHK RTWDPDQP-- ---------- --PRDLTDAF 
Cyp2d22               PGKRAFVTML D--ELLAEHK TTWDPTQP-- ---------- --PRDLTDAF 
Cyp2d26               PKLNSFIALV N--KMLIEHD LTWDPAQP-- ---------- --PRDLTDAF 
Cyp2e1                KNVSEIRQYT L--GKAKEHL KSLDIN-C-- ---------- --PRDVTDCL 
Cyp2f2                RNFGGMKDLI A--RSVREHQ DSLDPN-S-- ---------- --PRDFIDCF 
Cyp2g1                NLIEDLKDFI A--SRVKINE ASFDPS-N-- ---------- --PRDFIDCF 
Cyp2j5                RNWGKLKLFV S--HIVKKHE KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j6                RNWEKLKLFV S--CMIDDHR KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j7                RNWERLKMIV Y--HMMESHR KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j8                SNWEKLKLFF S---VMDSHR KDWNPSA--- ---------- --PRDFIDAF 
Cyp2j9                RNWRKLQLFV S--DIVNNHR RDWDPDE--- ---------- --PRDFIDAF 
Cyp2j13               ATWRKLKSYI A--DIIDNHR KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j12               RNWEKLKLFI Y--QMMESHR KDWNPDE--- ---------- --PRDFIDAF 
cyp2j11               SNWEKLKLFV S--RMMDSHR EDWNPSA--- ---------- --PRDFIDAF 
Cyp2r1                RNADVVYDFL S--RLIEKAA VNRKPHL--- ---------- --PHHFVDAY 
Cyp2s1                HHLGTLAAFT I--QQVQKHQ GRFQTSGP-- ---------- --ARDVVDAF 
Cyp2t4                KNFQELRLFI S--EQIQWHW QSRQTG-E-- ---------- --PRDFIDCF 
Cyp2U1                QIERDISCFL K--NIIREHQ ESLDASN--- ---------- --PQDFIDMY 
Cyp2w1                SKIEEVRTIL R--TLLETRR PPLPTGGP-- ---------- --AQSYVEAL 
CYP2W1h               RKIEEVRAIL R--TLLEARR PHVCPGDP-- ---------- --VCSYVDAL 
Cyp3a11               PVYEMLNICM FPKDSIEFFK KFVDRMKESR -LDSKQKH-- --RVDFLQLM 
Cyp3a13               PVFDALNVSL FPRDVISFFT TSVERMKENR -MKEKEKQ-- --RVDFLQLM 
Cyp3a16               PIYEMLNICM FPKDSIEFFK KFVDRMTENR -LDSKQKH-- --RVDFIYLM 
Cyp3a25               PIYEMLNFSI FPRDSMNFFK KFVKRMKKER -LASNQKN-- --RVDFLQLM 
Cyp3a57               PIYEMLNLSI FPRQSMNFFK KFVKKMKKDR -LDYNQKN-- --RVDFLQLM 
Cyp3a41               PVYEMLNICM FPKDSIEFFK KFVNRMKESR -LDSKQKH-- --RVDFLQLM 
Cyp3a44               PVYEMLNICM FPNDSIEFFK KFVDRMQESR -LDSNQKH-- --RVDFLQLM 
Cyp4a10               QACQLAHDHT --DGVIKLRK DQLQDEGELE KIKKKRR--- ---LDFLDIL 
Cyp4a12               SACKLAHDHT --DQVIKSRR IQLQDEEELE KLKKKRR--- ---LDFLDIL 
Cyp4a14               HACQIAHEHT --DGVIKMRK SQLQNEEELQ KARKKRH--- ---LDFLDIL 
Cyp4a30               HACQIAHKHT --ERVIRMRK AQLQNEAELE KFRKKKR--- ---LDFLDIL 
Cyp4a29               SACQIAHEHT --DRVVKLRK AQLQDNKSMK KLRGKRC--- ---LDFLDIL 
Cyp4b1                RACQIAHDHT --DHVIRQRK AALQDEKEQK KLQERRH--- ---LDFLDIL 
Cyp4f13               KACDLVHNFT --DAVIKERR STLN-TQGVE FLKAKAKT-- -KTLDFIDVL 
Cyp4f14               KACNVVHEFT --DAVIRERH RTLPDQGLDD FLKSKAKS-- -KTLDFIDVL 
Cyp4f15               KACHLVHSFT --DAVIQDRR RTLPSKHEDD VLKAKAKS-- -KTLDFIDVL 
Cyp4f16               KACDLVHNFT --DAVIRERR HTLSSQNHDE FLKSKTKS-- -KTLDFIDVL 
Cyp4f17               KACDLVHNFT --DAVIRERR RTLSSQNLDE FLKSKTKS-- -KTLDFIDVL 
Cyp4f18               KACRLVHDFT --DAVIRERR RTLLDQGGDD VLKAKAKA-- -KTLDFIDVL 
Cyp4f37               KACDLVHNFT --DAVIRERR HTLSSQNHDE FLKSKTKS-- -KTLDFIDVL 
Cyp4f39               QACDTVHNFT --TEVIQERR QALRQQGAEA WLKAKQG--- -KTLDFIDVL 
Cyp4f40               KACRLVHDFT --DAVIQERR RTLLKHGGDD IIKAKAKS-- -KTLDFIDVL 
Cyp4v3                RGLKCLHTFT --NNVIAERV KERKAEEDWT GAGRGPIPSK NKRKAFLDLL 
Cyp4x1                ELGKVIHQYT --EKIIQDRK KILKNQVKQD DTQTS----- ---QIFLDIV 
Cyp5a1                VPLARILPNK NRDELNGFFN TLIRNVIALR DQQAAEER-- --RRDFLQMV 
Cyp7a1                VPIHLLKTAH KARERLAESL KHKNLYMRDQ V--------- ----SELIRL 
Cyp7b1                IPIQLLRNEE SMQKKIIKCL TSEKVAQMQG Q--------- ----SKIVQE 
Cyp8a1                SLSAGDKDHA CSVKNRLWKL LSPARLASRA D--------- ----RSSWLE 
Cyp8b1                LLGPREWVEV SQLQRLFHQR LSVEQNLEKD G--------- ----ISCWLG 
Cyp11a1               AAWDVIFNKA D--EYTQNFY WDLRQK-R-- ---------- --DFSQYPGV 
Cyp11b1               ESWDFISEYG T--KCIKNVY RELAEG---- ---------- --RPQSWS-V 
Cyp11b2               DAWDVISEYG N--RCIWKVH QELRLG---- ---------- --SSQTYSGI 
Cyp17                 EHTKIREKTL V--EMFEKCK EKFNSE-S-- ---------- --LSSLTDIL 
Cyp19                 DEIAVLVEKK R--HKVSTAE KLEDC----- ---------- ---MDFATDL 
Cyp20                 EALMQLESTL --KKIIKERK GGNFR----- ---------- -----QHTFI 
Cyp21                 QIQESRDHIV K--QQLKRHK DSLVAG-Q-- ---------- --WKDMIDYM 
Cyp24                 LAWDTIFKSV K--PCIDHRL ERYSQQPG-- ---------- -------ADF 
Cyp26a1               GLYRGVKARN LIHARIEENI RAKIRRLQAT EPDGGCK--- ----DALQLL 
Cyp26b1               GYRRGIQARQ ILQKGLEKAI REKLQCTQGK DYS------- ----DALDIL 
Cyp26c1               GLRKGIRARD QLYEHLDEAV AEKLQEKQTA EPG------- ----DALLLI 
Cyp27a1               NGWDNIFSFG K--KLIDEKV QELKAQLQET ---------- GPDGVRVSGY 
Cyp27b1               RDWDQMFAFA Q--RHVELRE GEAAMRNQGK ---------- PEEDMPSGHH 
Cyp39                 LLRNWSKSKR WLLALFEKNI GNIKAHGSAG ---------- ----HSGTLL 
Cyp46                 ESIRLLRQVG --KDWVQRRR EALKRGED-- ---MPA---- ----DILTQI 
Cyp51                 SFRRRDRAHR EIKNIFYKAI QKRRLSKEPA E--------- ----DILQTL 
CYP1A1h               DLNEKFYSFM Q--KMVKEHY KTFEK-GH-- ---------- --IRDITDSL 
CYP1A2h               AFNQRFLWFL Q--KTVQEHY QDFDK-NS-- ---------- --VRDITGAL 
CYP1B1h               QLNRNFSNFI L--DKFLRHC ESLRPGAA-- ---------- --PRDMMDAF 
CYP2A6                QLLQGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
CYP2A7                KLLLGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PQDFIDSF 
CYP2A13               KELQGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
CYP2B6                KNLQEINAYI G--HSVEKHR ETLDPS-A-- ---------- --PKDLIDTY 
CYP2C8                KNVALTRSYI R--EKVKEHQ ASLDVN-N-- ---------- --PRDFMDCF 
CYP2C9                KNVAFMKSYI L--EKVKEHQ ESMDMN-N-- ---------- --PQDFIDCF 
CYP2C18               ENFAYIKSYV L--ERIKEHQ ESLDMN-S-- ---------- --ARDFIDCF 
CYP2C19               KNLAFMESDI L--EKVKEHQ ESMDIN-N-- ---------- --PRDFIDCF 
CYP2D6                RFQKAFLTQL D--ELLTEHR MTWDPAQP-- ---------- --PRDLTEAF 
CYP2E1h               KNVAEVKEYV S--ERVKEHH QSLDPN-C-- ---------- --PRDLTDCL 
CYP2F1                QNFKCLRDLI A--HSVHDHQ ASS------- ---------- --PRDFIQCF 
CYP2G2P               YLVEELKDFI A--SRVKINE ASFDPQ-N-- ---------- --PRDFIDCF 
CYP2J2                SNWKKLKLFV S--HMIDKHR KDWNPAE--- ---------- --TRDFIDAY 
CYP2R1h               RNAAVVYDFL S--RLIEKAS VNRKPQL--- ---------- --PQHFVDAY 
CYP2S1h               HHVSTLAAFT V--RQVQQHQ GNLDASGP-- ---------- --ARDLVDAF 
CYP2T2P               RNFSELRVIS ---EQIQRHW QMRQPA-E-- ---------- --PRDFIDCL 
CYP2U1h               QIEKDITSFL K--KIIKDHQ ESLDREN--- ---------- --PQDFIDMY 
CYP3A4                PILEVLNICV FPREVTNFLR KSVKRMKESR -LEDTQKH-- --RVDFLQLM 
CYP3A5                PVFEALNVSL FPKDTINFLS KSVNRMKKSR -LNDKQKH-- --RLDFLQLM 
CYP3A7                PILEALNITV FPRKVISFLT KSVKQIKEGR -LKETQKH-- --RVDFLQLM 
CYP3A43               PVFEALNIGL FPKDVTHFLK NSIERMKESR -LKDKQKH-- --RVDFFQQM 
CYP4A11               RACQLAHQHT --DQVIQLRK AQLQKEGELE KIKRKRH--- ---LDFLDIL 
CYP4A22               RACQLAHQHT --DQVIQLRK AQLQKEGELE KIKRKRH--- ---LDFLDIL 
CYP4B1h               RACQVAHDHT --DQVIRERK AALQDEKVRK KIQNRRH--- ---LDFLDIL 
CYP4F2                RACRLVHDFT --DAVIQERR RTLPSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4F3                RACRLVHDFT --DDVIQERR RTLPSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4F8                RACRLVHDFT --DAVIQERR RTLTSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4F11               RACHLVHDFT --DAVIQERR RTLPTQGIDD FLKNKAKS-- -KTLDFIDVL 
CYP4F12               RACRLVHDFT --DAVIRERR RTLPTQGIDD FFKDKAKS-- -KTLDFIDVL 
CYP4F22               QACDMVHHFT --TEVIQERR RALRQQGAEA WLKAKQG--- -KTLDFIDVL 
CYP4F23P              RACDIVHNFT --DAVIQERR RTLTSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4V2                KSLQILHTFT --NSVIAERA NEMNANEDCR GDGRGSAPSK NKRRAFLDLL 
CYP4X1h               KLSRVLNQYT --DTIIQERK KSLQAGVKQD NTPKRKY--- ---QDFLDIV 
CYP4Z1                KFNQELHQFT HLEKVIQDRK ESLKDKLKQD TTQKRR---- ---WDFLDIL 
CYP5A1h               VPLARILPNK NRDELNGFFN KLIRNVIALR DQQAAEER-- --RRDFLQMV 
CYP7A1h               LPIHMFRTAH NAREKLAESL RHENLQKRES I--------- ----SELISL 
CYP7B1h               IPIELLGNVK SIREKIIKCF SSEKLAKMQG W--------- ----SEVFQS 
CYP8A1h               SLSVGDKDHM CSVKSRLWKL LSPARLARRA H--------- ----RSKWLE 
CYP8B1h               LLWPREWLEV GRLQHLFHKM LSVSHSQEKE G--------- ----ISNWLG 
CYP11A1h              AAWDVIFSKA D--IYTQNFY WELRQKGS-- ---------- --VHHDYRGM 
CYP11B1h              EAWDCIFQYG D--NCIQKIY QELAFS---- ---------- --RPQQYTSI 
CYP11B2h              EAWDCIFQYG D--NCIQKIY QELAFN---- ---------- --RPQHYTGI 
CYP17h                SHVKIRNDLL N--KILENYK EKFRSD-S-- ---------- --ITNMLDTL 
CYP19h                DAIEVLIAEK R--CRISTEE KLEEC----- ---------- ---MDFATEL 
CYP20h                DALMQLESVL --RNIIKERK GRNFS----- ---------- -----QHIFI 
CYP21A2h              QAIEKRDHIV E--MQLRQHK ESLVAG-Q-- ---------- --WRDMMDYM 
CYP24h                LAWDTIFKSV K--ACIDNRL EKYSQQPS-- ---------- -------ADF 
CYP26A1h              GLYRGMKARN LIHARIEQNI RAKICGLRAS EAGQGCK--- ----DALQLL 
CYP26B1h              GYRRGIQARQ ILQKGLEKAI REKLQCTQGK DYL------- ----DALDLL 
CYP26C1h              GLRKGIRARD QLHRHLEGAI SEKLHEDKAA EPG------- ----DALDLI 
CYP27A1h              DGWNAIFSFG K--KLIDEKL EDMEAQLQAA ---------- GPDGIQVSGY 
CYP27B1h              RDWDQMFAFA Q--RHVERRE AEAAMRNGGQ ---------- PEKDLESGAH 
CYP27C1h              RSWDGLFKFS Q--IHVDNKL RDIQYQMD-- ---------- RGR-RVSGGL 
CYP39A1h              LLRNWSKSKK WFLELFEKNI PDIKACKSAK D--------- ----NSMTLL 
CYP46h                ESIRFLRQVG --RDWVQRRR EALKRGEE-- ---VPA---- ----DILTQI 
CYP51h                SFRRRDRAHR EIKDIFYKAI QKRRQSQEKI D--------- ----DILQTL 

Cyp1a1                IEHCQDRKL- ---------- ---------- ------DENA NVQLSDDKVI 
Cyp1a2                FKHSEN---- ---------- ---------- ------YKDN GGLIPEEKIV 
Cyp1b1                ILSAEKKASG ---------- ---------- -----APGDD SSGLDLEDVP 
Cyp2a4                LIRMLEEK-- ---------- ---------- ------KNPN TE-FYMKNLV 
Cyp2a5                LIRMLEEK-- ---------- ---------- ------KNPN TE-FYMKNLV 
Cyp2a12               LIHMQKE--- ---------- ---------- ------KYVN SE-FHMKNLV 
Cyp2b9                LLRMEKEK-- ---------- ---------- ------SNHN TE-FHHQNLM 
Cyp2b10               LLRMEKEK-- ---------- ---------- ------SNQH TE-FHHQNLM 
Cyp2b13               LLRMEKEK-- ---------- ---------- ------SNHN TE-FHHQNLM 
Cyp2b19               LLRMEKEK-- ---------- ---------- ------SNHH TE-FHHQNLV 
Cyp2b23               LLRMEKEK-- ---------- ---------- ------SNHH TE-FHHQNLL 
Cyp2c29               LIKQKQVN-- ---------- ---------- ------HIEQ SE-FSLENLA 
Cyp2c37               LINGGQED-- ---------- ---------- ------GNQP LQ-NRLEHLA 
Cyp2c38               LIKQKQAN-- ---------- ---------- ------HIEQ AE-YSLENLV 
Cyp2c39               LIKQKQAN-- ---------- ---------- ------HIQQ AE-FSLENLA 
Cyp2c40               LIQRRQKN-- ---------- ---------- ------GIEH MD-YTIEHLA 
Cyp2c44               LSKIEEEK-- ---------- ---------- ------HSLK SD-FNLENLA 
Cyp2c50               LINGGQED-- ---------- ---------- ------GNYP LK-NRLEHLA 
Cyp2c54               LIKGAQED-- ---------- ---------- ------DNHP LK-NNFEHLA 
Cyp2c55               LIKMEQEK-- ---------- ---------- ------HNPH SE-FTIESLM 
Cyp2c65               LIKMEQEK-- ---------- ---------- ------HNPK TE-FTCENLV 
Cyp2c66               LIKMEQEK-- ---------- ---------- ------HNPK TE-FTCENLI 
Cyp2c67               LIQRCQKK-- ---------- ---------- ------GIEH ME-YTIEHLA 
Cyp2c68               LIQRRQKN-- ---------- ---------- ------GIEH MD-YTIEHLA 
Cyp2c69               LIQRRQKN-- ---------- ---------- ------GIEH ME-YTIEHLA 
Cyp2c70               LIKMEKEK-- ---------- ---------- ------HNQK SE-FTMDNLV 
Cyp2d9                LAQIEKAK-- ---------- ---------- ------GNPE SS-FNDENLL 
Cyp2d10               LAEIEKVK-- ---------- ---------- ------GNAE SS-FNDENLR 
Cyp2d11               LAEIEKAK-- ---------- ---------- ------GNAE SS-FNDENLR 
Cyp2d12               LAEIEKAK-- ---------- ---------- ------GNPE SS-FNDENLR 
Cyp2d13               LAEMEKAK-- ---------- ---------- ------GNPK SS-FNEANLR 
Cyp2d22               LAEVEKAK-- ---------- ---------- ------GNPE SS-FNDENLR 
Cyp2d26               LAEVEKAK-- ---------- ---------- ------GNPE SS-FNDKNLR 
Cyp2e1                LIEMEKEK-- ---------- ---------- ------HSQE PM-YTMENIS 
Cyp2f2                LTKMAQEK-- ---------- ---------- ------QDPL SH-FNMDTLL 
Cyp2g1                LIKMHQDK-- ---------- ---------- ------SDPH TE-FNLKNLV 
Cyp2j5                LIEMQKDP-- ---------- ---------- ------DRTT S--FNEENLI 
Cyp2j6                LKEMTKYP-- ---------- ---------- ------EKTT S--FNEENLI 
Cyp2j7                LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2j8                LTEMAKYS-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2j9                LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2j13               LNEMAKYP-- ---------- ---------- ------GKTT TS-FNEENLI 
Cyp2j12               LTEMSKYG-- ---------- ---------- ------DKTT TS-FNEENLI 
cyp2j11               LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2r1                LDEMDQGQ-- ---------- ---------- ------NDPL ST-FSKENLI 
Cyp2s1                LLKMAQEK-- ---------- ---------- ------QDPG TE-FTEKNLL 
Cyp2t4                LDQMDKEQ-- ---------- ---------- ------QDLE SH-FQDETLV 
Cyp2U1                LLHMEEEQ-- ---------- ---------- ------GASR RSSFDEDYLF 
Cyp2w1                LQQGQEDD-- ---------- ---------- --------PE DM-FGEANVL
CYP2W1h               IQQGQGDD-- ---------- ---------- --------PE GL-FAEANAV
Cyp3a11               MNSHNNS--- ---------- ---------- -----KDKVS HKALSDMEIT 
Cyp3a13               INSQN-Y--- ---------- ---------- -----KTKES HKALSDVEIV 
Cyp3a16               MEAYNKS--- ---------- ---------- -----KDKDS HKALSEIEIT 
Cyp3a25               MNTQN-S--- ---------- ---------- -----KGQES QKALSDLEMA 
Cyp3a57               MNTQN-S--- ---------- ---------- -----KGQES LKALSDLEMA 
Cyp3a41               MNAHNNS--- ---------- ---------- -----KDKDS HKALSDMEIT 
Cyp3a44               MNSHNNS--- ---------- ---------- -----KDKDS HKAFSNMEIT 
Cyp4a10               LFARME---- ---------- ---------- ---------N GDSMSDKDLR 
Cyp4a12               LFARME---- ---------- ---------- ---------N GKSLSDKDLR 
Cyp4a14               LFARME---- ---------- ---------- ---------D RNSLSDEDLR 
Cyp4a30               LFAQTE---- ---------- ---------- ---------D GKSLSDEDVR 
Cyp4a29               LLSRVSS--- ---------- ---------- --------DD GSSLSDKALR 
Cyp4b1                LGARDE---- ---------- ---------- ---------S GIKLSDADLR 
Cyp4f13               LMAEDE---- ---------- ---------- ---------H GKGLSNEDIR 
Cyp4f14               LLSKDE---- ---------- ---------- ---------D GKELSDEDIR 
Cyp4f15               LLSKDE---- ---------- ---------- ---------D GKELSDEDIR 
Cyp4f16               LLAKDE---- ---------- ---------- ---------H GKELSDEDIR 
Cyp4f17               LLAKDE---- ---------- ---------- ---------H GKELSDEDIR 
Cyp4f18               LLSKDE---- ---------- ---------- ---------H GKALSDEDIR 
Cyp4f37               LLAKDE---- ---------- ---------- ---------H GKELSDEDIR 
Cyp4f39               LLAKDE---- ---------- ---------- ---------E GKELSDEDIR 
Cyp4f40               LLTKDE---- ---------- ---------- ---------D GKELSDEDIR 
Cyp4v3                LSVTDE---- ---------- ---------- ---------E GNRLSQEDIR 
Cyp4x1                LSAQGK---- ---------- ---------- --------ED ERAFSDADLR 
Cyp5a1                LDAQHSMNSV GVEGFDMVPE SLSSSECTKE PPQRCHPTST SKPFTVDEIV 
Cyp7a1                RMFLND---- ---------- ---------- ---------T LSTFDDMEKA 
Cyp7b1                SQDLLK---- ---------- ---------- ---------R YYRHDDSEIG 
Cyp8a1                SYLRHL---- ---------- ---------- ---------E EMGVSEEMQA 
Cyp8b1                YMLQFL---- ---------- ---------- ---------R EQGIASSMQD 
Cyp11a1               LYSLLGGNK- ---------- ---------- ---------- ---LPFKNIQ 
Cyp11b1               TAELVAERT- ---------- ---------- ---------- ---LSMDAIQ 
Cyp11b2               VAELISQGS- ---------- ---------- ---------- ---LPLDAIK 
Cyp17                 IQAKMNAENN NT-------- ---------- -----GEGQD PSVFSDKHIL 
Cyp19                 IFAERRGD-- ---------- ---------- ---------- ---LTKENVN 
Cyp20                 DSLTQG---- ---------- ---------- ---------- --KLNEQQIL 
Cyp21                 LQGVEK-QRD ---------- ---------- -----G--KD EERLHEGHVH 
Cyp24                 LCDIYQQDH- ---------- ---------- ---------- ---LSKKELY 
Cyp26a1               IEHSWE---- ---------- ---------- ---------R GERLDMQALK 
Cyp26b1               IESSKE---- ---------- ---------- ---------H GKEMTMQELK 
Cyp26c1               INSARE---- ---------- ---------- ---------L GHEPSVQELK 
Cyp27a1               LHFLLTNEL- ---------- ---------- ---------- ---LSTQETI 
Cyp27b1               LTHFLFREK- ---------- ---------- ---------- ---VSVQSIV 
Cyp39                 QAILEV---- ---------- ---------- ---------V ETETR-QYSP 
Cyp46                 LKAEEG---- ---------- ---------- ---------- --AQDDEVLL 
Cyp51                 LDSTYK---- ---------- ---------- ---------D GRPLTDEEIS 
CYP1A1h               IEHCQEKQL- ---------- ---------- ------DENA NVQLSDEKII 
CYP1A2h               FKHSKKG--- ---------- ---------- ------PRAS GNLIPQEKIV 
CYP1B1h               ILSAEKKAAG ---------- ---------- -----DSHGG GARLDLENVP 
CYP2A6                LIRMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLV 
CYP2A7                LIHMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLM 
CYP2A13               LIRMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLV 
CYP2B6                LLHMEKEK-- ---------- ---------- ------SNAH SE-FSHQNLN 
CYP2C8                LIKMEQEK-- ---------- ---------- ------DNQK SE-FNIENLV 
CYP2C9                LMKMEKEK-- ---------- ---------- ------HNQP SE-FTIESLE 
CYP2C18               LIKMEQEK-- ---------- ---------- ------HNQQ SE-FTVESLI 
CYP2C19               LIKMEKEK-- ---------- ---------- ------QNQQ SE-FTIENLV 
CYP2D6                LAEMEKAK-- ---------- ---------- ------GNPE SS-FNDENLR 
CYP2E1h               LVEMEKEK-- ---------- ---------- ------HSAE RL-YTMDGIT 
CYP2F1                LTKMAEEK-- ---------- ---------- ------EDPL SH-FHMDTLL 
CYP2G2P               LIKMHQDK-- ---------- ---------- ------NNPR TE-FNLKNLV 
CYP2J2                LKEMSKHT-- ---------- ---------- ------GNPT SS-FHEENLI 
CYP2R1h               LDEMDQGK-- ---------- ---------- ------NDPS ST-FSKENLI 
CYP2S1h               LLKMAQEE-- ---------- ---------- ------QNPG TE-FTNKNML 
CYP2T2P               TRWVRHGQ-- ---------- ---------- ------QDPE SH-FQETSVM 
CYP2U1h               LLHMEEER-- ---------- ---------- ------KNNS NSSFDEEYLF 
CYP3A4                IDSQN-S--- ---------- ---------- -----KETES HKALSDLELV 
CYP3A5                IDSQN-S--- ---------- ---------- -----KETES HKALSDLELA 
CYP3A7                IDSQN-S--- ---------- ---------- -----KDSET HKALSDLELM 
CYP3A43               IDSQN-S--- ---------- ---------- -----KETKS HKALSDLELV 
CYP4A11               LLAKME---- ---------- ---------- ---------N GSILSDKDLR 
CYP4A22               LLAKME---- ---------- ---------- ---------N GSILSDKDLR 
CYP4B1h               LGARDE---- ---------- ---------- ---------D DIKLSDADLR 
CYP4F2                LLSKDE---- ---------- ---------- ---------D GKKLSDEDIR 
CYP4F3                LLSKDE---- ---------- ---------- ---------D GKKLSDEDIR 
CYP4F8                LLSEDK---- ---------- ---------- ---------N GKELSDEDIR 
CYP4F11               LLSKDE---- ---------- ---------- ---------D GKELSDEDIR 
CYP4F12               LLSKDE---- ---------- ---------- ---------D GKALSDEDIR 
CYP4F22               LLARDE---- ---------- ---------- ---------D GKELSDEDIR 
CYP4F23P              LLAKDE---- ---------- ---------- ---------N GKKLSDENIR 
CYP4V2                LSVTDD---- ---------- ---------- ---------E GNRLSHEDIR 
CYP4X1h               LSAKD----- ---------- ---------- --------ES GSSFSDIDVH 
CYP4Z1                LSAKV----- ---------- ---------- --------EN TKDFSEADLQ 
CYP5A1h               LDARHSASPM GVQDFDIVRD VFSSTGCKPN PSRQHQPSPM ARPLTVDEIV 
CYP7A1h               RMFLND---- ---------- ---------- ---------T LSTFDDLEKA 
CYP7B1h               RQDVLE---- ---------- ---------- ---------K YYVHEDLEIG 
CYP8A1h               SYLLHL---- ---------- ---------- ---------E EMGVSEEMQA 
CYP8B1h               NMLQFL---- ---------- ---------- ---------R EQGVPSAMQD 
CYP11A1h              LYRLLGDSK- ---------- ---------- ---------- ---MSFEDIK 
CYP11B1h              VAELLLNAE- ---------- ---------- ---------- ---LSPDAIK 
CYP11B2h              VAELLLKAE- ---------- ---------- ---------- ---LSLEAIK 
CYP17h                MQAKMNSDNG NA-------- ---------- -----GPDQD SELLSDNHIL 
CYP19h                ILAEKRGD-- ---------- ---------- ---------- ---LTRENVN 
CYP20h                DSLVQG---- ---------- ---------- ---------- --NLNDQQIL 
CYP21A2h              LQGVAQ-PSM ---------- ---------- -----E--EG SGQLLEGHVH 
CYP24h                LCDIYHQNR- ---------- ---------- ---------- ---LSKKELY 
CYP26A1h              IEHSWE---- ---------- ---------- ---------R GERLDMQALK 
CYP26B1h              IESSKE---- ---------- ---------- ---------H GKEMTMQELK 
CYP26C1h              IHSARE---- ---------- ---------- ---------L GHEPSMQELK 
CYP27A1h              LHFLLASGQ- ---------- ---------- ---------- ---LSPREAM 
CYP27B1h              LTHFLFREE- ---------- ---------- ---------- ---LPAQSIL 
CYP27C1h              LTYLFLSQA- ---------- ---------- ---------- ---LTLQEIY 
CYP39A1h              QATLDI---- ---------- ---------- ---------V ETETSKENSP 
CYP46h                LKAEEG---- ---------- ---------- ---------- --AQDDEGLL 
CYP51h                LDATYK---- ---------- ---------- ---------D GRPLTDDEVA 

Cyp1a1                TIVLDLFGAG FDTVTTAISW SLMYLVTNPR VQRKIQEELD TVIG--RDR- 
Cyp1a2                NIVNDIFGAG FDTVTTAITW SILLLVTWPN VQRKIHEELD TVVG--RDR- 
Cyp1b1                ATITDIFGAS QDTLSTALLW LLILFTRYPD VQARVQAELD QVVG--RDR- 
Cyp2a4                LTTQNLFFAG TETGSTTLRY GFLLLMKYPD IEAKVHEEID RVIG--RNR- 
Cyp2a5                LTTLNLFFAG TETVSTTLRY GFLLLMKHPD IEAKVHEEID RVIG--RNR- 
Cyp2a12               MTSLNLFFAG SETVSSTLRY GFLLLMKHPD VEAKVHEEID RVIG--RNR- 
Cyp2b9                MSVLSLFFAG TETTSATLHY GVLLMLKYPH VTEKVQKEID QVIG--SHR- 
Cyp2b10               MSVLSLFFAG TETSSTTLRY GFLLMLKYPH VAEKVQKEID QVIG--SHR- 
Cyp2b13               MSVLSLFFAG TETTSTTLCC GFLLMLMYPH VAGKVQKEID QVIG--SHR- 
Cyp2b19               ISVLSLFFAG TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIG--SHR- 
Cyp2b23               ISVLSLFFAG TETTSTTLRY GFLLMLKYPH VAEKVQKEID QVIS--AHH- 
Cyp2c29               STINDLFGAG TETTSTTLRY ALLLLLKYPD VTAKVQEEID RVVG--RHR- 
Cyp2c37               ITVTDLFSAG TETTSTTLRY ALLLLLKYPH VTAKVQKEIE HVIG--KHR- 
Cyp2c38               CTINNLFAAG TETTSTTLRY ALLLLMKYPD VTAKVQEEID HVVG--RHR- 
Cyp2c39               CTINNLFAAG TETTSTTLRY ALLLLMKYPD VTAKVQEEID HVIG--RHR- 
Cyp2c40               TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c44               ICGSNLFTAG TETTSTTLRF GLLLLVKHPE VQAKVHEELD RVIG--RHQ- 
Cyp2c50               ITVTDLFSAG TETTSTTLRY ALLLLLKYPH VTAKVQEEIE HVIG--KHR- 
Cyp2c54               ITVTDLFIGG TESMSTTLRY ALLLLLKYPH VTAKVQEEIE HVIG--KHR- 
Cyp2c55               ATVTDIFVAG TETTNITLRY GLLLLLKHTE VTAKVQAEID HVIG--RHR- 
Cyp2c65               FTASDLFAAG TETTSTTLRY SLLLLLKYPE VTAKVQEEID CVIG--RHR- 
Cyp2c66               FTASDLFAAG TETTSTTLRY SLLLLLKYPE VTAKVQAEID CVIG--RHR- 
Cyp2c67               TLVTDLVFGG TESLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c68               TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c69               TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c70               VSIGDLFGAG TETTSSTVKY GLLLLLKYPE VTAKIQEEIA HVIG--RHR- 
Cyp2d9                MVVRDLFGAG MLTTSTTLSW ALMLMILHPD VQRRVQQEID EVIG--QVR- 
Cyp2d10               MVVLDLFTAG MVTTSTTLSW ALLLMILHPD VQRRVQQEID AVIG--QVR- 
Cyp2d11               MVVLDLFTAG MVTTSTTLSW ALLLMILHPD VQRRVQQEID AVIG--QVQ- 
Cyp2d12               MVVIDLFTAG ILTTSTTLSW ALLLMILHPD VQRRVQQEID EVIG--QVR- 
Cyp2d13               LVVFDLFGAG IVTSSITLTW ALLLMILHPD VQRRVQEEID EVIG--QVR- 
Cyp2d22               TVVGDLFSAG MVTTSTTLSW ALMLMILHPD VQRRVQQEID EVIG--QVQ- 
Cyp2d26               IVVIDLFMAG MVTTSTTLSW ALLLMILHPD VQRRVHQEID EVIG--HVR- 
Cyp2e1                VTLADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIG--PSR- 
Cyp2f2                MTTHNLLFGG TETVGTTLRH AFLILMKYPK VQARVQEEID RVVG--RSR- 
Cyp2g1                LTTLNLFFAG TETVSSTLRY GFLLLLKYPE VEAKIHEEIN QVIG--THR- 
Cyp2j5                STTLDLFLGG TETTSSTLRW ALLYMSSYPE IQENVQAEID RVIG--HKR- 
Cyp2j6                CSTLDLFFAG TETTSTTLRW ALLYMALYPE VQEKVQAEID RVIG--QKR- 
Cyp2j7                CSCLDLFIAG TETSSTALRW ALLYMTLNPE VQERVHSEID GVIG--QWR- 
Cyp2j8                CTTLDLFFAG TETTSTALRW ALLYITVNPE VQEKVHSEID RVIG--QGR- 
Cyp2j9                CSTLDLFFAG TETTSTTLRW ALLCMALYPE VQEKMQAEID RVIG--QAR- 
Cyp2j13               CSTLDLFLAG TETTSSTLRW ALLYMALYPE VQENVQAEID RVIG--QSK- 
Cyp2j12               NSTLDLFFAG SETTTNTLRW ALLYITTNPE VQEKVHSEID RVIG--HGR- 
cyp2j11               CTALDLFFAG TETTSNTLRW ALLYITVNPE VQEKVHSEID RVIG--HGR- 
Cyp2r1                FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVHKEID LIVG--HNR- 
Cyp2s1                MTVTYLLFAG TMTIGATIRY ALLLLLRYPQ VQQRVREELI QELG--PGR- 
Cyp2t4                MTTHDLFFGG TETTSTTLRY GLLIMLKYPE VAAKVQEELD ATVG--RTW- 
Cyp2U1                YIIGDLFIAG TDTTTNSLLW CLLYMSLNPD VQKKVHEEIE RVIG--CDR- 
Cyp2w1                ACTLDMVMAG TETTAATLQW AVFLMVKHPH VQGRVQEELD RVLG--PGQ- 
CYP2W1h               ACTLDMVMAG TETTSATLQW AALLMGRHPD VQGRVQEELD RVLG--PGR- 
Cyp3a11               AQSIIFIFAG YETTSSTLSF TLHSLATHPD IQKKLQDEID EALP---NKA 
Cyp3a13               AQSVIFIFAG YETTSSALSF ALYLLAIHPD VQKKLQDEID AALP---NKA 
Cyp3a16               AQSIIFIFAG YETTSSILSF TVYSLATHPD IQKKLQEEID EALP---NKA 
Cyp3a25               AQAVIFIFGG YDATSTSISL IMYELATHPD VQKKLQDEID RTLP---NKA 
Cyp3a57               AQTLIFIFGG YDGTSTSISF IMYELATHPD VQKKLQDEID RALP---NKA 
Cyp3a41               AQSIVFIFAG YETTSSTLSF TLYCLATHPD IQKKLQEEID ETLP---NKA 
Cyp3a44               VQSIIFISAG YETTSSTLSF TLYCLATHPD IQKKLQAEID KALP---NKA 
Cyp4a10               AEVDTFMFEG HDTTASGVSW IFYALATHPD HQQRCREEVQ SLLG---DGS 
Cyp4a12               AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ SLLG---DGT 
Cyp4a14               AEVDTFMFEG HDTTASGISW IFYALATHPE HQQRCREEVQ SILG---DGT 
Cyp4a30               AEMDTFMFEG HNTTASGISW IFYALATHPE HQQRCREEVK SILG---NGT 
Cyp4a29               AEVDSLMFGG HDTPASGISW VFYALATHPD HQQRCREEVQ SLLG---DGS 
Cyp4b1                AEVDTFMFEG HDTTTSGISW FLYCMALYPM HQQRCREEVR EILG---DRD 
Cyp4f13               AEADTFMFGG HDTTTSALSW ILYNLARHPE YQERCRQEVQ ELLR---DRD 
Cyp4f14               AEADTFMFEG HDTTASGLSW ILYNLARHPE YQERCRQEVQ ELLR---GRE 
Cyp4f15               AEADTFMFEG HDTTASGLSW ILYNLARHPE YQERCRQEVQ ELLR---DRE 
Cyp4f16               AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---DRE 
Cyp4f17               AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---GRE 
Cyp4f18               AEADTFMFGG HDTTASGLSW ILYNLARHPE YQERCRQEVR ELLR---DRE 
Cyp4f37               AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---GRE 
Cyp4f39               AEADTFMFEG HDTTSSGLSW ALFNLAKYPE YQEKCREEIQ EVMK---GRE 
Cyp4f40               AEADTFMFRG HDTTASGLSW ILYNLARHPE HQERCRQEVQ ELLR---DRD 
Cyp4v3                EEVDTFMFEG HDTTAAAINW SLYLLGTNPE VQRKVDQELD EVFG---RSH 
Cyp4x1                AEVNTFMWAG HDASAASISW LLYCLALNPE HQDRCRTEIR SILG---DGS 
Cyp5a1                GQAFLFLIAG HEVITNTLSF ITYLLATHPD CQERLLKEVD LFMG---KHP 
Cyp7a1                KTHLVILWAS QANTIPATFW SLFQMIRSPE AMKAASEEVN GSLQSAGQEL 
Cyp7b1                AHHLGFLWAS LANTIPAMFW AMYYILRHPE AMEALRDEID SFLQSTGQKK 
Cyp8a1                RALVLQLWAT QGNMGPTAFW LLLFLLKNPE ALAAVRAELK HTVWQAEQPV 
Cyp8b1                KFNFMMLWAS QGNTGPTCFW VLLFLLKHQD AMKAVREEAT RVMGKARLEA 
Cyp11a1               ANITEMLAGG VDTTSMTLQW NLYEMAHNLK VQEMLRAEVL AARR--QAQ- 
Cyp11b1               ANSMELIAGS TDTTSTPLVM TFFELARNPD VQQALRQESL AAEA--SIA- 
Cyp11b2               ANSMELTAGS VDTTAIPLVM TLFELARNPD VQKALRQESL AAEA--SIA- 
Cyp17                 VTVGDIFGAG IETTSSVLNW ILAFLVHNPE VKRKIQKEID QYVG--FSR- 
Cyp19                 QCILEMLIAA PDTMSVTLYF MLLLVAEYPE VEAAILKEIH TVVG---DR- 
Cyp20                 EDCVVFSLAS CIITARLCTW TIHFLTTTGE VQKKLCKEID QVLG---EG- 
Cyp21                 MSVVDLFIGG TETTATTLSW AVAFLLHHPE IQKRLQEELD LKLG--PGS- 
Cyp24                 AAVTELQLAA VETTANSLMW ILYNLSRNPQ VQQRLLREIQ SVLP--DNQ- 
Cyp26a1               QSSTELLFGG HETTASAATS LITYLGLYPH VLQKVREEIK SKGLLCKSNQ 
Cyp26b1               DGTLELIFAA YATTASASTS LIMQLLKHPA VLEKLREELR AQGLLHGGGC 
Cyp26c1               ELAVELLFAA FFTTASASTS LILLLLQHPA AITKIQQELS AQGLGRACTC 
Cyp27a1               GTFPELLLAG VDTTSNTLTW ALYHLSKSPE IQEALHKEVT GVVP--FGK- 
Cyp27b1               GNVTELLLAG VDTVSNTLSW TLYELSRHPD VQTALHSEIT AGTR-GSCA- 
Cyp39                 NYGLVVLWAA LANAPPIAFW TLGYILSHPD IHRTVLESIS SVFGTAGKDK 
Cyp46                 DNFVTFFIAG HETSANHLAF TVMELSRQPE IVARLQAEVD EVVG---SKR 
Cyp51                 GMLIGLLLAG QHTSSTTSAW MGFFLAKDKP LQEKCYLEQK AVCGEDLPP- 
CYP1A1h               NIVLDLFGAG FDTVTTAISW SLMYLVMNPR VQRKIQEELD TVIG--RSR- 
CYP1A2h               NLVNDIFGAG FDTVTTAISW SLMYLVTKPE IQRKIQKELD TVIG--RER- 
CYP1B1h               ATITDIFGAS QDTLSTALQW LLLLFTRYPD VQTRVQAELD QVVG--RDR- 
CYP2A6                MTTLNLFIGG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- 
CYP2A7                MSTLNLFIAG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- 
CYP2A13               MTTLNLFFAG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- 
CYP2B6                LNTLSLFFAG TETTSTTLRY GFLLMLKYPH VAERVYREIE QVIG--PHR- 
CYP2C8                GTVADLFVAG TETTSTTLRY GLLLLLKHPE VTAKVQEEID HVIG--RHR- 
CYP2C9                NTAVDLFGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVIG--RNR- 
CYP2C18               ATVTDMFGAG TETTSTTLRY GLLLLLKYPE VTAKVQEEIE CVVG--RNR- 
CYP2C19               ITAADLLGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVIG--RNR- 
CYP2D6                IVVADLFSAG MVTTSTTLAW GLLLMILHPD VQRRVQQEID DVIG--QVR- 
CYP2E1h               VTVADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIG--PSR- 
CYP2F1                MTTHNLLFGG TKTVSTTLHH AFLALMKYPK VQARVQEEID LVVG--RAR- 
CYP2G2P               LTTLNLFFAG TETVSSTLRY GFLLLMKHPE VEAKIHEEIN QVIG--PHR- 
CYP2J2                CSTLDLFFAG TETTSTTLRW ALLYMALYPE IQEKVQVEID RVIG--QGQ- 
CYP2R1h               FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVQKEID LIMG--PNG- 
CYP2S1h               MTVIYLLFAG TMTVSTTVGY TLLLLMKYPH VQKWVREELN RELG--AGQ- 
CYP2T2P               TT--HFFFGV TETTSTTLCY GLLILLKYLE VAAKVQELDP VVG---WRP- 
CYP2U1h               YIIGDLFIAG TDTTTNSLLW CLLYMSLNPD VQEKVHEEIE RVIG--ANR- 
CYP3A4                AQSIIFIFAG YETTSSVLSF IMYELATHPD VQQKLQEEID AVLP---NKA 
CYP3A5                AQSIIFIFAG YETTSSVLSF TLYELATHPD VQQKLQKEID AVLP---NKA 
CYP3A7                AQSIIFIFAG YETTSSVLSF IIYELATHPD VQQKVQKEID TVLP---NKA 
CYP3A43               AQSIIIIFAA YDTTSTTLPF IMYELATHPD VQQKLQEEID AVLP---NKA 
CYP4A11               AEVDTFMFEG HDTTASGISW ILYALATHPK HQERCREEIH SLLG---DGA 
CYP4A22               AEVDTFMFEG HDTTASGISW ILYALATHPK HQERCREEIH GLLG---DGA 
CYP4B1h               AEVDTFMFEG HDTTTSGISW FLYCMALYPE HQHRCREEVR EILG---DQD 
CYP4F2                AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQERCRQEVQ ELLK---DRE 
CYP4F3                AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQERCRQEVQ ELLK---DRE 
CYP4F8                AEADTFMFGG HDTTASGLSW VLYNLARHPE YQERCRQEVQ ELLK---DRE 
CYP4F11               AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQEQCRQEVQ ELLK---DRE 
CYP4F12               AEADTFMFGG HDTTASGLSW VLYNLARHPE YQERCRQEVQ ELLK---DRD 
CYP4F22               AEADTFMFEG HDTTSSGISW MLFNLAKYPE YQEKCREEIQ EVMK---GRE 
CYP4F23P              AEADTFMSGG HDTTASGLSW VLYNLARYPE YQEHCRQEVQ ELLK---NGD 
CYP4V2                EEVDTFMFEG HDTTAAAINW SLYLLGSNPE VQKKVDHELD DVK-----SD 
CYP4X1h               SEVSTFLLAG HDTLAASISW ILYCLALNPE HQERCREEVR GILG---DGS 
CYP4Z1                AEVKTFMFAG HDTTSSAISW ILYCLAKYPE HQQRCRDEIR ELLG---DGS 
CYP5A1h               GQAFIFLIAG YEIITNTLSF ATYLLATNPD CQEKLLREVD VFKE---KHM 
CYP7A1h               KTHLVVLWAS QANTIPATFW SLFQMIRNPE AMKAATEEVK RTLENAGQKV 
CYP7B1h               AHHLGFLWAS VANTIPTMFW AMYYLLRHPE AMAAVRDEID RLLQSTGQKK 
CYP8A1h               RALVLQLWAT QGNMGPAAFW LLLFLLKNPE ALAAVRGELE SILWQAEQPV 
CYP8B1h               KFNFMMLWAS QGNTGPTSFW ALLYLLKHPE AIRAVREEAT QVLGEARLET 
CYP11A1h              ANVTEMLAGG VDTTSMTLQW HLYEMARNLK VQDMLRAEVL AARH--QAQ- 
CYP11B1h              ANSMELTAGS VDTTVFPLLM TLFELARNPN VQQALRQESL AAAA--SIS- 
CYP11B2h              ANSMELTAGS VDTTAFPLLM TLFELARNPD VQQILRQESL AAAA--SIS- 
CYP17h                TTIGDIFGAG VETTTSVVKW TLAFLLHNPQ VKKKLYEEID QNVG--FSR- 
CYP19h                QCILEMLIAA PDTMSVSLFF MLFLIAKHPN VEEAIIKEIQ TVIG---ER- 
CYP20h                EDSMIFSLAS CIITAKLCTW AICFLTTSEE VQKKLYEEIN QVFG---NG- 
CYP21A2h              MAAVDLLIGG TETTANTLSW AVVFLLHHPE IQQRLQEELD HELG--PGAS 
CYP24h                AAVTELQLAA VETTANSLMW ILYNLSRNPQ VQQKLLKEIQ SVLP--ENQ- 
CYP26A1h              QSSTELLFGG HETTASAATS LITYLGLYPH VLQKVREELK SKGLLCKSNQ 
CYP26B1h              DGTLELIFAA YATTASASTS LIMQLLKHPT VLEKLRDELR AHGILHSGGC 
CYP26C1h              ESAVELLFAA FFTTASASTS LVLLLLQHPA AIAKIREELV AQGLGRACGC 
CYP27A1h              GSLPELLMAG VDTTSNTLTW ALYHLSKDPE IQEALHEEVV GVVP--AGQ- 
CYP27B1h              GNVTELLLAG VDTVSNTLSW ALYELSRHPE VQTALHSEIT AALSPGSSA- 
CYP27C1h              ANVTEMLLAG VDTTSFTLSW TVYLLARHPE VQQTVYREIV KNLG--ERH- 
CYP39A1h              NYGLLLLWAS LSNAVPVAFW TLAYVLSHPD IHKAIMEGIS SVFGKAGKDK 
CYP46h                DNFVTFFIAG HETSANHLAF TVMELSRQPE IVARLQAEVD EVIG---SKR 
CYP51h                GMLIGLLLAG QHTSSTTSAW MGFFLARDKT LQKKCYLEQK TVCGENLPP- 

Cyp1a1                ---------- --------QP RLS------- DRPQLPYLEA FILETFRHS- 
Cyp1a2                ---------- --------QP RLS------- DRPQLPYLEA FILEIYRYT- 
Cyp1b1                ---------- --------LP CMS------- DQPNLPYVMA FLYESMRFS- 
Cyp2a4                ---------- --------QP KYE------- DRMKMPYTEA VIHEIQRFA- 
Cyp2a5                ---------- --------QP KYE------- DRMKMPYTEA VIHEIQRFA- 
Cyp2a12               ---------- --------QP QYE------- DHMKMPYTQA VINEIQRFS- 
Cyp2b9                ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- 
Cyp2b10               ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- 
Cyp2b13               ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- 
Cyp2b19               ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFT- 
Cyp2b23               ---------- --------VP TLE------- DRIKMPYTEA VIHEIQRFS- 
Cyp2c29               ---------- --------SP CMQ------- DRSHMPYTDA MIHEVQRFI- 
Cyp2c37               ---------- --------SP CMQ------- DRSRMPYTDA MIHEVQRFI- 
Cyp2c38               ---------- --------SP CMQ------- DRSHMPYTDA MIHEVQRFI- 
Cyp2c39               ---------- --------SP CMQ------- DRNHMPYTDA MIHEVQRFI- 
Cyp2c40               ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYI- 
Cyp2c44               ---------- --------PP SMK------- DKMKLPYTDA VLHEIQRYI- 
Cyp2c50               ---------- --------SP CMQ------- DRSRMPYTDA MIHEVQRFI- 
Cyp2c54               ---------- --------RP CMQ------- DRSHMPYTNA MIHEVQRFI- 
Cyp2c55               ---------- --------SP CMQ------- DRTRMPYTDA MVHEIQRYI- 
Cyp2c65               ---------- --------SP CMQ------- DRHSMPYTDA VLHEIQRYI- 
Cyp2c66               ---------- --------SP CMQ------- DRHSMPYTDA VLHEIQRYI- 
Cyp2c67               ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYV- 
Cyp2c68               ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYI- 
Cyp2c69               ---------- --------SP CMQ------- DRKHMPYTNA MVHEVQRYV- 
Cyp2c70               ---------- --------RP TMQ------- DRNHMPYTDA VLHEIQRYI- 
Cyp2d9                ---------- --------HP EMA------- DQAHMPYTNA VIHEVQRFG- 
Cyp2d10               ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFG- 
Cyp2d11               ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFGT 
Cyp2d12               ---------- --------HP EMA------- DQAHMPYTNA VIHEVQRFG- 
Cyp2d13               ---------- --------CP EMA------- DQAHMPYTNA VIHEVQRFA- 
Cyp2d22               ---------- --------CP EMA------- DQARMPYTNA VIHEVQRFA- 
Cyp2d26               ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFA- 
Cyp2e1                ---------- --------AP AVR------- DRMNMPYMDA VVHEIQRFI- 
Cyp2f2                ---------- --------MP TLE------- DRTSMPYTDA VIHEVQRFA- 
Cyp2g1                ---------- --------TP RVD------- DRAKMPYTDA VIHEIQRLT- 
Cyp2j5                ---------- --------QV SLS------- DRESMPYTNA VIHEVQRMG- 
Cyp2j6                ---------- --------AA RLA------- DRESMPYTNA VIHEVRRMG- 
Cyp2j7                ---------- --------QP STG------- DRDSMPYTNA VIHEVLRMG- 
Cyp2j8                ---------- --------HP TID------- DRDSMPYTNA VIHEVLRMG- 
Cyp2j9                ---------- --------QP NLA------- DRDSMPYTNA VIHEVQRMG- 
Cyp2j13               ---------- --------HP SLA------- DRDSMPYTNA VVHEILRMG- 
Cyp2j12               ---------- --------QP STD------- DRDSMPYTNA VIHEVLRMG- 
cyp2j11               ---------- --------HP TLD------- DQDSMPYTNA VIHEVLRMG- 
Cyp2r1                ---------- --------RP SWE------- YKCKMPYTEA VLHEVLRFC- 
Cyp2s1                ---------- --------AP SLS------- DRVRLPYTDA VLHEAQRLL- 
Cyp2t4                ---------- --------AP RIE------- DRARLPYTNA VLHEIQRFI- 
Cyp2U1                ---------- --------AP SLT------- DKAQMPYTEA TIMEVQRLS- 
Cyp2w1                ---------- --------LP QPE------- HQRALPYTSA VLHEVQRYI- 
CYP2W1h               ---------- --------TP RLE------- DQQALPYTSA VLHEVQRFI- 
Cyp3a11               PP-------- --------TY DTVME----- ----MEYLDM VLNETLRLYP 
Cyp3a13               PA-------- --------TY DTLLQ----- ----MEYLDM VVNETLRLYP 
Cyp3a16               PP-------- --------TY DTVMA----- ----MEYLDM VLNETLRLYP 
Cyp3a25               PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP 
Cyp3a57               PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP 
Cyp3a41               PP-------- --------TY DTVME----- ----MEYLDM VLNETLRLYP 
Cyp3a44               TP-------- --------TC DTVME----- ----MEYLDM VLNETLRLYP 
Cyp4a10               S--------- ---------I TWD------- HLDQIPYTTM CIKEALRLYP 
Cyp4a12               S--------- ---------I TWN------- DLDKMPYTTM CIKEALRIYP 
Cyp4a14               S--------- ---------V TWD------- HLGQMPYTTM CIKEALRLYP 
Cyp4a30               S--------- ---------V TN-------- HLDQMPYTTM CIKEALRLYP 
Cyp4a29               P--------- ---------I TWD------- HLHQMPYTTM CIKEALRLYP 
Cyp4b1                S--------- ---------F QWD------- DLAQMTYLTM CMKECFRLYP 
Cyp4f13               SE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f14               PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f15               ST-------- --------EI ECSCAVFLRD DLAQLPFLTM CIKESLRLHP 
Cyp4f16               PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHS 
Cyp4f17               PQ-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f18               PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f37               PQ-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f39               LE-------- --------EL DWD------- DLTQLPFTTM CIKESLRQFP 
Cyp4f40               PK-------- --------EI EW-------D DLAQLPFLTM CIKESLRLHP 
Cyp4v3                RP-------- --------VT LED------- -LKKLKYLDC VIKETLRVFP 
Cyp4x1                S--------- ---------I TWE------- QLDEMSYTTM CIKETLRLIP 
Cyp5a1                AP-------- --------EY HSLQEG---- ----LPYLDM VISETLRMYP 
Cyp7a1                SS-------- ----GGNAIY LDQE------ QLNNLPVLDS IIKEALRLSS 
Cyp7b1                G--------- ----PGISVH FTRE------ QLDSLVCLES TILEVLRLCS 
Cyp8a1                S--------- ------QMTT LPQK------ ILDSMPVLDS VLNETLRLTA 
Cyp8b1                K--------- ------KSFT FTPS------ ALKHTPVLDS VMEESLRLCA 
Cyp11a1               ---------- --------GD MAK------- MVQLVPLLKA SIKETLRLH- 
Cyp11b1               ---------- --------AN PQK------- AMSDLPLLRA ALKETLRLY- 
Cyp11b2               ---------- --------AN PQK------- AMSDLPLLRA ALKETLRLY- 
Cyp17                 ---------- --------TP SFN------- DRTHLLMLEA TIREVLRIR- 
Cyp19                 ---------- --------DI KIE------- DIQNLKVVEN FINESMRYQ- 
Cyp20                 PI-------- --------TS EK-------- -IEQLSYCQQ VLFETVRTAK 
Cyp21                 ---------- --------QL LYR------- NRMQLPLLMA TIAEVLRLR- 
Cyp24                 ---------- --------TP RAE------- DVRNMPYLKA CLKESMRLT- 
Cyp26a1               D--------- --------NK LDME------ TLEQLKYIGC VIKETLRLNP 
Cyp26b1               P--------- ------CEGT LRLD------ TLSSLRYLDC VIKEVMRLFT 
Cyp26c1               TPRASGS--- -PPDCGCEPD LSLA------ MLGRLRYVDC VVKEVLRLLP 
Cyp27a1               ---------- --------VP QHK------- DFAHMPLLKA VIKETLRLY- 
Cyp27b1               ---------- --------HP HGT------- ALSQLPLLKA VIKEVLRLY- 
Cyp39                 ---------- --------IK VSED------ DLKKLLIIKW CILESVRLRA 
Cyp46                 HL-------- --------DY ED-------- -LGRLQYLSQ VLKESLRLYP 
Cyp51                 ---------- ---------- LTYD------ QLKDLNLLDR CIKETLRLRP 
CYP1A1h               ---------- --------RP RLS------- DRSHLPYMEA FILETFRHS- 
CYP1A2h               ---------- --------RP RLS------- DRPQLPYLEA FILETFRHS- 
CYP1B1h               ---------- --------LP CMG------- DQPNLPYVLA FLYEAMRFS- 
CYP2A6                ---------- --------QP KFE------- DRAKMPYMEA VIHEIQRFG- 
CYP2A7                ---------- --------QP KFE------- DRTKMPYMEA VIHEIQRFG- 
CYP2A13               ---------- --------QP KFE------- DRAKMPYTEA VIHEIQRFG- 
CYP2B6                ---------- --------PP ELH------- DRAKMPYTEA VIYEIQRFS- 
CYP2C8                ---------- --------SP CMQ------- DRSHMPYTDA VVHEIQRYS- 
CYP2C9                ---------- --------SP CMQ------- DRSHMPYTDA VVHEVQRYI- 
CYP2C18               ---------- --------SP CMQ------- DRSHMPYTDA VVHEIQRYI- 
CYP2C19               ---------- --------SP CMQ------- DRGHMPYTDA VVHEVQRYI- 
CYP2D6                ---------- --------RP EMG------- DQAHMPYTTA VIHEVQRFG- 
CYP2E1h               ---------- --------IP AIK------- DRQEMPYMDA VVHEIQRFI- 
CYP2F1                ---------- --------LP ALK------- DRAAMPYTDA VIHEVQRFA- 
CYP2G2P               ---------- --------LP RVD------- DRVKMPYTDA VIHEIQRLV- 
CYP2J2                ---------- --------QP STA------- ARESMPYTNA VIHEVQRMG- 
CYP2R1h               ---------- --------KP SWD------- DKCKMPYTEA VLHEVLRFC- 
CYP2S1h               ---------- --------AP SLG------- DRTRLPYTDA VLHEAQRLL- 
CYP2T2P               ---------- --------AP SLD------- YRVCLPYANA VLLEIQCFI- 
CYP2U1h               ---------- --------AP SLT------- DKAQMPYTEA TIMEVQRLT- 
CYP3A4                PP-------- --------TY DTVLQ----- ----MEYLDM VVNETLRLFP 
CYP3A5                PP-------- --------TY DAVVQ----- ----MEYLDM VVNETLRLFP 
CYP3A7                PP-------- --------TY DTVLQ----- ----LEYLDM VVNETLRLFP 
CYP3A43               PV-------- --------TY DALVQ----- ----MEYLDM VVNETLRLFP 
CYP4A11               S--------- ---------I TWN------- HLDQMPYTTM CIKEALRLYP 
CYP4A22               S--------- ---------I TWN------- HLDQMPYTTM CIKEALRLYP 
CYP4B1h               F--------- ---------F QWD------- DLGKMTYLTM CIKESFRLYP 
CYP4F2                PK-------- --------EI EWD------- DLAHLPFLTM CMKESLRLHP 
CYP4F3                PK-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
CYP4F8                PK-------- --------EI EWD------- DLAQLPFLTM CLKESLRLHP 
CYP4F11               PI-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
CYP4F12               PK-------- --------EI EWD------- DLAQLPFLTM CVKESLRLHP 
CYP4F22               LE-------- --------EL EWD------- DLTQLPFTTM CIKESLRQYP 
CYP4F23P              PK-------- --------EI EWD------- DLAQLPFLTM CLKESLRLHS 
CYP4V2                RP-------- --------AT VED------- -LKKLRYLEC VIKETLRLFP 
CYP4X1h               S--------- ---------I TWD------- QLGEMSYTTM CIKETCRLIP 
CYP4Z1                S--------- ---------I TWE------- HLSQMPYTTM CIKECLRLYA 
CYP5A1h               AP-------- --------EF CSLEEG---- ----LPYLDM VIAETLRMYP 
CYP7A1h               SL-------- ----EGNPIC LSQA------ ELNDLPVLDS IIKESLRLSS 
CYP7B1h               G--------- ----SGFPIH LTRE------ QLDSLICLES SIFEALRLSS 
CYP8A1h               S--------- ------QTTT LPQK------ VLDSTPVLDS VLSESLRLTA 
CYP8B1h               K--------- ------QSFA FKLG------ ALQHTPVLDS VVEETLRLRA 
CYP11A1h              ---------- --------GD MAT------- MLQLVPLLKA SIKETLRLH- 
CYP11B1h              ---------- --------EH PQK------- ATTELPLLRA ALKETLRLY- 
CYP11B2h              ---------- --------EH PQK------- ATTELPLLRA ALKETLRLY- 
CYP17h                ---------- --------TP TIS------- DRNRLLLLEA TIREVLRLR- 
CYP19h                ---------- --------DI KID------- DIQKLKVMEN FIYESMRYQ- 
CYP20h                PV-------- --------TP EK-------- -IEQLRYCQH VLCETVRTAK 
CYP21A2h              SS-------- --------RV PYK------- DRARLPLLNA TIAEVLRLR- 
CYP24h                ---------- --------RP REE------- DLRNMPYLKA CLKESMRLT- 
CYP26A1h              D--------- --------NK LDME------ ILEQLKYIGC VIKETLRLNP 
CYP26B1h              P--------- ------CEGT LRLD------ TLSGLRYLDC VIKEVMRLFT 
CYP26C1h              APGAAGGSEG PPPDCGCEPD LSLA------ ALGRLRYVDC VVKEVLRLLP 
CYP27A1h              ---------- --------VP QHK------- DFAHMPLLKA VLKETLRLY- 
CYP27B1h              ---------- --------YP SAT------- VLSQLPLLKA VVKEVLRLY- 
CYP27C1h              ---------- --------VP TAA------- DVPKVPLVRA LLKETLRLF- 
CYP39A1h              ---------- --------IK VSED------ DLENLLLIKW CVLETIRLKA 
CYP46h                YL-------- --------DF ED-------- -LGRLQYLSQ VLKESLRLYP 
CYP51h                ---------- ---------- LTYD------ QLKDLNLLDR CIKETLRLRP 

Cyp1a1                SFVPFTIPHS TTRDT----- ----SLNGFY IPKGCCVFVN QWQ-VNHDRE 
Cyp1a2                SFVPFTIPHS TTRDT----- ----SLNGFH IPKERCIYIN QWQ-VNHDEK 
Cyp1b1                SFLPVTIPHA TTANT----- ----FVLGYY IPKNTVVFVN QWS-VNHDPA 
Cyp2a4                DLIPMGLARR VTKDT----- ----KFRDFL LPKGTEVFPM LGS-VLKDPK 
Cyp2a5                DMIPMGLARR VTKDT----- ----KFRDFL LPKGTEVFPM LGS-VLKDPK 
Cyp2a12               NFAPLGIPRR ITKNT----- ----SFRGFF LPKATEVFPI LGS-LMTDPK 
Cyp2b9                DLVPIGLPHK VIKDT----- ----LFRGYL LPKNTEVYPV LSS-ALHDPQ 
Cyp2b10               DLIPIGVPHR VTKDT----- ----MFRGYL LPKNTEVYPI LSS-ALHDPQ 
Cyp2b13               DIVPTGAPHR VTKDT----- ----MFRGYL LPKNTEVYPI LSS-ALHDPQ 
Cyp2b19               DLAPIGLPHK VTKDT----- ----LFRGYL IPKNTEVYPI LSS-ALHDPR 
Cyp2b23               DLAPIGLPHT VTKDT----- ----VFRGYL LPKNTEVYPI LSS-ALHDPQ 
Cyp2c29               DLLPTSLPHA VTCDI----- ----KFRKYL IPKGTTVITS LSS-VLHDSK 
Cyp2c37               DLIPNSLPHE VTCDI----- ----KFRNYF IPKGTTVITS LSS-VLHDST 
Cyp2c38               NLVPNNLPHA VTCDI----- ----KFRNYI IPKGTTVVTS LTS-VLHDSK 
Cyp2c39               NLVPNNIPRA VTCDI----- ----KFRNYL IPKGTTVVTS LTS-VLHDSK 
Cyp2c40               DLGPNGVVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST 
Cyp2c44               TLLPSSLPHA VVQDT----- ----KFRHYV IPKGTAVFPF LSS-ILLDQK 
Cyp2c50               DLVPNSLPHE VTCDI----- ----KFRNYF IPKGTNVITS LSS-VLRDSK 
Cyp2c54               DLVPNNLPHE VTCDI----- ----KFRNYF IPKGTTVITS LSS-VLRDSK 
Cyp2c55               DLIPNNVPHA ATCNV----- ----RFRSYF IPKGTELVTS LTS-VLHDDK 
Cyp2c65               DLLPTSLPHA VTRDV----- ----KFREYL IPKGTTVIAS LTS-VLYDDK 
Cyp2c66               DLLPTSLPHA VTRDV----- ----KFREYL IPKGTTVIAS LTS-VLYDDK 
Cyp2c67               DLGPISLVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST 
Cyp2c68               DLGPNGVVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST 
Cyp2c69               DLGPTSLVHE VTCDT----- ----KFRNYF IPKGTQVMTS LSS-VLHDST 
Cyp2c70               DFVPIPSPRK TTQDV----- ----EFRGYH IPKGTSVMAC LTS-VLNDDK 
Cyp2d9                DIVPVNLPRI TSHDI----- ----EVQDFL IPKGTILLPN MSS-MLKDES 
Cyp2d10               DIAPLNLPRI TSRDI----- ----EVQDFL IPKGSILIPN MSS-VLKDET 
Cyp2d11               LLHCLCHASQ VVTFT----- ----QVQDFL VTKGSTLIPN LSS-VLKGET 
Cyp2d12               DIVPLHLPRI TSRDI----- ----EVQDFL IPKGTILLPN MSS-VHMDDT 
Cyp2d13               DIVPMNLPHK TSHDI----- ----EVQGFL IPKGTTLIPN LSS-ALKDET 
Cyp2d22               DILPLGVPHK TSRDI----- ----ELQGFL IPKGTTLITN LSS-ALKDET 
Cyp2d26               DIVPTNLPHM TSRDI----- ----KFQDFF IPKGTTLIPN LSS-VLKDET 
Cyp2e1                NLVPSNLPHE ATRDT----- ----VFRGYV IPKGTVVIPT LDS-LLFDNY 
Cyp2f2                DVIPMNLPHR VTRDT----- ----PFRGFL IPKGTDVITL LNT-VHYDSD 
Cyp2g1                DIVPLGVPHN VTRDT----- ----HFRGYL LPKGTDVYPL FGS-VLKDPK 
Cyp2j5                NIVPLNSSRE VTVDT----- ----KFNGFH LPKGTMILTN LTA-LHRDPK 
Cyp2j6                NIIPLNVPRE VAMDT----- ----NLNGFH LPKGTMVLTN LTA-LHRDPK 
Cyp2j7                NIVPLNVPRE VTADS----- ----TLAGFH LPKGKMILTN LTA-LHRDPK 
Cyp2j8                NIIPLNVPRE VEADI----- ----TLAGFH LPKGTMVLTN LTA-LHRDPK 
Cyp2j9                NIIPFNVPRE VAVDT----- ----QLAGFN LPKGIMVLSN LTA-LHRDPS 
Cyp2j13               NSVPLNIPRE VAVDT----- ----TLAGFH LPKRSVVMTN LTA-LHMDPK 
Cyp2j12               NILPMNVPRE VTADS----- ----TLAGFH LPKGTMVLTN LTA-LHRDPK 
cyp2j11               NIIPLNVPRE VTADS----- ----TLAGFY LPKGTMVLIN LTD-LHRDPK 
Cyp2r1                NIVPLGIFHA TSEDA----- ----VVRGYS IPKGTTVITN LYS-VHFDEK 
Cyp2s1                ALVPMGMPHT ITRTT----- ----CFRGYT LPKGTEVFPL IGS-ILHDPA 
Cyp2t4                SVLPLGLPRA LTRDV----- ----NLKNHF LHKGTFVIPL LVS-AHRDPT 
Cyp2U1                MVVPLAIPHM TSEKT----- ----VLQGFT IPKGTVVLIN LWS-VHRDPA 
Cyp2w1                TLLP-HVPRC TAADI----- ----QLGGYL LPKGTPVIPL LTS-VLLDKT 
CYP2W1h               TLLP-HVPRC TAADT----- ----QLGGFL LPKGTPVIPL LTS-VLLDET 
Cyp3a11               IANRLERVCK KDVELN---- ------G-VY IPKGSTVMIP SYA-LHHDPQ 
Cyp3a13               IAGRLERVCK TDVEIN---- ------G-LF IPKGTVVMIP TFA-LHKDPK 
Cyp3a16               ITNRLQRVCK KDVEIN---- ------G-IY IPKGSTVIIP SYV-LHHDPQ 
Cyp3a25               IAIRLERVSK KDVEIN---- ------G-VF IPKGTVVMIP IYP-LHRNPE 
Cyp3a57               VVSRIDRFSK KDVEIH---- ------G-VF IPKGTIVMIP IYP-LHRDPE 
Cyp3a41               IGNRLERFCK KDVELN---- ------G-VY IPKGSTVMIP SYA-LHHDPQ 
Cyp3a44               IVTRLERVCK KDVELN---- ------G-VY IPKGSMVMIP SYA-LHHDPQ 
Cyp4a10               PVPGIVRELS TSVTFP---- ------DGRS LPKGVQVTLS IYG-LHHNPK 
Cyp4a12               PVPSVSRELS SPVTFP---- ------DGRS LPKGIHVMLS FYG-LHHNPT 
Cyp4a14               PVISVSRELS SPVTFP---- ------DGRS IPKGITATIS IYG-LHHNPR 
Cyp4a30               PIPGASRELS SPVTFP---- ------DGCS LPKGFLVTLS FYG-LHHNPR 
Cyp4a29               PIPSVGRKLS TPVTFP---- ------DGRS LPKGIESTVS CFI-FFSAWK 
Cyp4b1                PVPQVYRQLS KPVTFV---- ------DGRS LPAGSLISLH IYA-LHRNSA 
Cyp4f13               PVLLISRCCT QDVLLP---- ------DGRA IPKGNICVIS IFG-VHHNPS 
Cyp4f14               PVTVISRCCT QDILLP---- ------DGRT IPKGIICLIS IFG-IHHNPS 
Cyp4f15               PVTVISRRCT QDIVLP---- ------DGRV IPKGVICIIN IFA-THHNPT 
Cyp4f16               PVIDLLRRCT RDIVLP---- ------DGRV IPKGNICVIS IFG-IHHNPS 
Cyp4f17               PVTVISRCCT QDVVLP---- ------DGRV IPKGTDCVIS IFG-VHHNPE 
Cyp4f18               PVTAISRCCT QDIVLP---- ------DGRV IPKGVISRIS IFG-THHNPA 
Cyp4f37               PVIDLLRRCT RDIVLP---- ------DGRV IPKGNICVIS IFG-IHHNPS 
Cyp4f39               PVTLISRRCT EDIKLP---- ------DGRV IPKGIICLVS IYG-THHNPI 
Cyp4f40               PVTMVSRCCT QDISLP---- ------DGRI IPKGVICIIN IFG-THHNPT 
Cyp4v3                SVPLFARSLS EDCEVG---- ------G-YK VTKGTEAIII PYA-LHRDPR 
Cyp4x1                PVPSISRELS KPLTLP---- ------DGHS LPAGMTVVLS IWG-LHHNPA 
Cyp5a1                PAFRFTREAA QDCEVL---- ------G-QR IPAGTVLEIA VGA-LHHDPE 
Cyp7a1                ASLNIRTAKE DFTLHLED-- -----G-SYN IRKDDIIALY PQL-MHLDPE 
Cyp7b1                YSSIIREVQE DMNLSLES-- -----K-SFS LRKGDFVALF PPL-IHNDPE 
Cyp8a1                APFITREVMA DLALPMAD-- -----GREFS LRRGDRLLLF PFLSPQKDPE 
Cyp8b1                TPTLLRVVQE DYVLKMAS-- -----GQEYQ IRRGDKVALF PYLSVHMDPD 
Cyp11a1               PISVTLQ-RY TVNDL----- ----VLRNYK IPAKTLVQVA SFA-MGRDPG 
Cyp11b1               PVGTFLE-RI LSSDL----- ----VLQNYH VPAGTVLNVN LYS-MGRNPA 
Cyp11b2               PVGGFLE-RI LSSDL----- ----VLQNYH VPAGTLVLLY LYS-MGRNPA 
Cyp17                 PVAPLLIPHK ANIDS----- ----SIGEFA IPKDTHVIIN LWA-LHHDKN 
Cyp19                 PVVDLVMRRA LEDDV----- -----IDGYP VKKGTNIILN IGR-MHRLEY 
Cyp20                 LTPVSARLQD IEGKVG---- ------P-FV IPKETLVLYA LGV-VLQDPS 
Cyp21                 PVVPLALPHR ATRAS----- ----SISGYD IPKDMVIIPN IQG-ANLDEM 
Cyp24                 PSVPFTT-RT LDKPT----- ----VLGEYT LPKGTVLTLN TQV-LGSSED 
Cyp26a1               PVPGGFRVAL KTFELNG--- --------YQ IPKGWNVIYS ICDTHDVADI 
Cyp26b1               PVSGGYRTVL QTFELDG--- --------FQ IPKGWSVMYS IRDTHDTAPV 
Cyp26c1               PVSGGYRTAL RTFELDG--- --------YQ IPKGWSVMYS IRDTHETAAV 
Cyp27a1               PVVPTNSRII TEKET----- ----EINGFL FPKNTQFVLC HYV-VSRDPS 
Cyp27b1               PVVPGNS-RV PDRDI----- ----RVGNYV IPQDTLVSLC HYA-TSRDPT 
Cyp39                 PGVITRKVVK PVKILN---- --------HT VPSGDLLMLS PFW-LHRNPK 
Cyp46                 PAWGTFRLLE EETLID---- ------G-VR VPGNTPLLFS TYV-MGRMDT 
Cyp51                 PIMTMMRMAK TPQTVAG--- --------YT IPPGHQVCVS PTV-NQRLKD 
CYP1A1h               SFVPFTIPHS TTRDT----- ----SLKGFY IPKGRCVFVN QWQ-INHDQK 
CYP1A2h               SFLPFTIPHS TTRDT----- ----TLNGFY IPKKCCVFVN QWQ-VNHDPE 
CYP1B1h               SFVPVTIPHA TTANT----- ----SVLGYH IPKDTVVFVN QWS-VNHDPV 
CYP2A6                DVIPMSLARR VKKDT----- ----KFRDFF LPKGTEVYPM LGS-VLRDPS 
CYP2A7                DVIPMSLARR VKKDT----- ----KFRDFF LPKGTEVFPM LGS-VLRDLR 
CYP2A13               DMLPMGLAHR VNKDT----- ----KFRDFF LPKGTEVFPM LGS-ELRDPR 
CYP2B6                DLLPMGVPHI VTQHT----- ----SFRGYI IPKDTEVFLI LST-ALHDPH 
CYP2C8                DLVPTGVPHA VTTDT----- ----KFRNYL IPKGTTIMAL LTS-VLHDDK 
CYP2C9                DLLPTSLPHA VTCDI----- ----KFRNYL IPKGTTILIS LTS-VLHDNK 
CYP2C18               DLLPTNLPHA VTCDV----- ----KFKNYL IPKGTTIITS LTS-VLHNDK 
CYP2C19               DLIPTSLPHA VTCDV----- ----KFRNYL IPKGTTILTS LTS-VLHDNK 
CYP2D6                DIVPLGMTHM TSRDI----- ----EVQGFR IPKGTTLITN LSS-VLKDEA 
CYP2E1h               TLVPSNLPHE ATRDT----- ----IFRGYL IPKGTVVVPT LDS-VLYDNQ 
CYP2F1                DIIPMNLPHR VTRDT----- ----AFRGFL IPKGTDVITL LNT-VHYDPS 
CYP2G2P               DIVPMGVPHN LIRDT----- ----QFRGYL LPKGTDVFPL LGS-VLKDPK 
CYP2J2                NIIPQNVPRE VTVDT----- ----TLAGYH LPKGTMILTN LTA-LHRDPT 
CYP2R1h               NIVPLGIFHA TSEDA----- ----VVRGYS IPKGTTVITN LYS-VHFDEK 
CYP2S1h               ALVPMGIPRT LMRTT----- ----RFRGYT LPQGTEVFPL LGS-ILHEPN 
CYP2T2P               SVVPLGLPRT LTLDT----- ----HLHSHC LPKGTFVIPL LVT-AHRDPT 
CYP2U1h               VVVPLAIPHM TSENT----- ----VLQGYT IPKGTLILPN LWS-VHRDPA 
CYP3A4                IAMRLERVCK KDVEIN---- ------G-MF IPKGWVVMIP SYA-LHRDPK 
CYP3A5                VAIRLERTCK KDVEIN---- ------G-VF IPKGSMVVIP TYA-LHHDPK 
CYP3A7                VAMRLERVCK KDVEIN---- ------G-MF IPKGVVVMIP SYV-LHHDPK 
CYP3A43               VVSRVTRVCK KDIEIN---- ------G-VF IPKGLAVMVP IYA-LHHDPK 
CYP4A11               PVPGIGRELS TPVTFP---- ------DGRS LPKGIMVLLS IYG-LHHNPK 
CYP4A22               PVPGIGRELS TPVTFP---- ------DGRS LPKGIMVLLS IYG-LHHNPK 
CYP4B1h               PVPQVYRQLS KPVTFV---- ------DGRS LPAGSLISMH IYA-LHRNSA 
CYP4F2                PVPVISRHVT QDIVLP---- ------DGRV IPKGIICLIS VFG-THHNPA 
CYP4F3                PVPAVSRCCT QDIVLP---- ------DGRV IPKGIICLIS VFG-THHNPA 
CYP4F8                PIPTFARGCT QDVVLP---- ------DSRV IPKGNVCNIN IFA-IHHNPS 
CYP4F11               PVPVISRCCT QDFVLP---- ------DGRV IPKGIVCLIN IIG-IHYNPT 
CYP4F12               PAPFISRCCT QDIVLP---- ------DGRV IPKGITCLID IIG-VHHNPT 
CYP4F22               PVTLVSRQCT EDIKLP---- ------DGRI IPKGIICLVS IYG-THHNPT 
CYP4F23P              PVSRIHRCCP QDGVLP---- ------DGRV IPKGNTCTIS IFG-IHHNPS 
CYP4V2                SVPLFARSVS EDYFLT---- ------AGYR VLKGTEAVII PYA-LHRDPR 
CYP4X1h               AVPSISRDLS KPLTFP---- ------DGCT LPAGITVVLS IWG-LHHNPA 
CYP4Z1                PVVNISRLLD KPITFP---- ------DGRS LPAGITVFIN IWA-LHHNPY 
CYP5A1h               PAFRFTREAA QDCEVL---- ------G-QR IPAGAVLEMA VGA-LHHDPE 
CYP7A1h               ASLNIRTAKE DFTLHLED-- -----G-SYN IRKDSIIALY PQL-MHLDPE 
CYP7B1h               YSTTIRFVEE DLTLSSET-- -----G-DYC VRKGDLVAIF PPV-LHGDPE 
CYP8A1h               APFITREVVV DLAMPMAD-- -----GREFN LRRGDRLLLF PFLSPQRDPE 
CYP8B1h               APTLLRLVHE DYTLKMSS-- -----GQEYL FRHGDILALF PYLSVHMDPD 
CYP11A1h              PISVTLQ-RY LVNDL----- ----VLRDYM IPAKTLVQVA IYA-LGREPT 
CYP11B1h              PVGLFLE-RV ASSDL----- ----VLQNYH IPAGTLVRVF LYS-LGRNPA 
CYP11B2h              PVGLFLE-RV VSSDL----- ----VLQNYH IPAGTLVQVF LYS-LGRNAA 
CYP17h                PVAPMLIPHK ANVDS----- ----SIGEFA VDKGTEVIIN LWA-LHHNEK 
CYP19h                PVVDLVMRKA LEDDV----- -----IDGYP VKKGTNIILN IGR-MHRLEF 
CYP20h                LTPVSAQLQD IEGKID---- ------R-FI IPRETLVLYA LGV-VLQDPN 
CYP21A2h              PVVPLALPHR TTRPS----- ----SISGYD IPEGTVIIPN LQG-AHLDET 
CYP24h                PGVPFTT-RT LDKAT----- ----VLGEYA LPKGTVLMLN TQV-LGSSED 
CYP26A1h              PVPGGFRVAL KTFELNG--- --------YQ IPKGWNVIYS ICDTHDVAEI 
CYP26B1h              PISGGYRTVL QTFELDG--- --------FQ IPKGWSVMYS IRDTHDTAPV 
CYP26C1h              PVSGGYRTAL RTFELDG--- --------YQ IPKGWSVMYS IRDTHETAAV 
CYP27A1h              PVVPTNS-RI IEKEI----- ----EVDGFL FPKNTQFVFC HYV-VSRDPT 
CYP27B1h              PVVPGNS-RV PDKDI----- ----HVGDYI IPKNTLVTLC HYA-TSRDPA 
CYP27C1h              PVLPGNG-RV TQEDL----- ----VIGGYL IPKGTQLALC HYA-TSYQDE 
CYP39A1h              PGVITRKVVK PVEILN---- --------YI IPSGDLLMLS PFW-LHRNPK 
CYP46h                PAWGTFRLLE EETLID---- ------G-VR VPGNTPLLFS TYV-MGRMDT 
CYP51h                PIMIMMRMAR TPQTVAG--- --------YT IPPGHQVCVS PTV-NQRLKD 

Cyp1a1                LWGDPNEFRP ERFLTPSG-- -TLDKR---- LSEKVTLFGL G--KRKCIGE 
Cyp1a2                QWKDPFVFRP ERFLTNNNS- -AIDKT---- QSEKVMLFGL G--KRRCIGE 
Cyp1b1                KWPNPEDFDP ARFLDKDG-- -FINKA---- LASSVMIFSV G--KRRCIGE 
Cyp2a4                FFSNPKDFNP KHFLDDKG-- ---QFK---- KSDAFVPFSI G--KRYCFGE 
Cyp2a5                FFSNPKDFNP KHFLDDKG-- ---QFK---- KNDAFVPFSI G--KRYCFGE 
Cyp2a12               FFSSPKDFNP QHFLDDKG-- ---QLK---- KIPAFLPFST G--KRFCLGD 
Cyp2b9                YFEQPDKFNP EHFLDANG-- ---ALK---- KCEAFLPFST G--KRICLGE 
Cyp2b10               YFEQPDSFNP DHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE 
Cyp2b13               YFEQPDSFNP DHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE 
Cyp2b19               YFEQPDSFNP EHFLDANG-- ---ALK---- TNEAFMPFST G--KRICLGE 
Cyp2b23               YFEQPDKFNP EHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE 
Cyp2c29               EFPNPEMFDP GHFLNGNG-- ---NFK---- KSDYFMPFST G--KRICAGE 
Cyp2c37               EFPNPEVFDP GHFLDGNG-- ---KFK---- KSDYFMPFST G--KRICAGE 
Cyp2c38               EFPNPEMFDP GHFLDANG-- ---NFK---- KSDYFMTFSA G--KRVCAGE 
Cyp2c39               EFPNPELFDP GHFLDANG-- ---NFK---- KSDHFMPFSA G--KRVCAGE 
Cyp2c40               EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFMPFSA G--KRICVGE 
Cyp2c44               EFPNPEKFDP GHFLDKNG-- ---CFK---- KTDYFVPFSL G--KRSCVGE 
Cyp2c50               EFPNPEKFDP GHFLDENG-- ---KFK---- KSDYFMPFST G--KRICAGE 
Cyp2c54               EFPNPEKFDP GHFLDENG-- ---KFK---- KSDYFMPFST G--KRICAGE 
Cyp2c55               EFPNPEVFDP GHFLDENG-- ---NFK---- KSDYFMPFSI G--KRMCVGE 
Cyp2c65               EFPNPEKFDP SHFLDERG-- ---KFK---- KSDYFFPFST G--KRICVGE 
Cyp2c66               EFLNPERFDP SHFLDESG-- ---KFK---- KSDYFFPFST G--KRICVGE 
Cyp2c67               EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA G--KRICVGE 
Cyp2c68               EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA ---------- 
Cyp2c69               EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA G--KRICVGE 
Cyp2c70               EFPNPEKFDP GHFLDEKG-- ---NFK---- KSDYFVAFSA G--RRACIGE 
Cyp2d9                VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d10               VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d11               VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--HRSCLGE 
Cyp2d12               VWEKPLRFHP EHFLDAQG-- ---HFV---- KHEAFITFSA G--RRSCLGE 
Cyp2d13               VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRACLGE 
Cyp2d22               VWEKPLCFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d26               VWEKPLRFYP EHFLDAQG-- ---HFV---- KHEAFMPFSA G--RRSCLGE 
Cyp2e1                EFPDPETFKP EHFLNENG-- ---KFK---- YSDYFKAFSA G--KRVCVGE 
Cyp2f2                QFKTPQEFNP EHFLDDNH-- ---SFK---- KSPAFMPFSA G--RRLCLGE 
Cyp2g1                YFRYPDAFYP QHFLDEQG-- ---RFK---- KNDAFVVFSS G--KRICVGE 
Cyp2j5                EWATPEVFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j6                EWATPDVFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j7                EWATPDIFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACPGE 
Cyp2j8                EWATPDVFNP EHFLE-NG-- ---QFK---- KRESFLPFSV G--KRGCPGE 
Cyp2j9                EWTTPDTFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j13               EWATPDIFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j12               EWATPNTFNP EHFLE-NG-- ---QFK---- KRESFLPFSL G--KRACPGE 
cyp2j11               EWDTPNVFNP EHFLE-NG-- ---QFK---- KKESFLPFSM G--KRACPGE 
Cyp2r1                YWKDPDMFYP ERFLDSNG-- ---YFT---- KKEALIPFSL G--RRHCLGE 
Cyp2s1                VFQNPGEFHP GRFLDEDG-- ---RLR---- KHEAFLPYSL G--KRVCLGE 
Cyp2t4                QFKDPDHFNP TNFLDDHG-- ---EFQ---- NNDAFMPFAL G--KRMCLGA 
Cyp2U1                IWEKPDDFCP HRFLDDQG-- ---QLL---- KRETFIPFGI G--------- 
Cyp2w1                QWETPSQFNP NHFLDAKG-- ---RFM---- KRGAFLPFSA G--RRVCVGK 
CYP2W1h               QWQTPGQFNP GHFLDANG-- ---HFV---- KREAFLPFSA G--RRVCVGE 
Cyp3a11               HWSEPEEFQP ERFSKENK-- -------GSI DPYVYLPFGN G--PRNCLGM 
Cyp3a13               YWPEPEEFRP ERFSKKNQ-- -------DSI NPYMYLPFGS G--PRNCIGM 
Cyp3a16               HWPEPEEFQP ERFSKENK-- -------GSI DPYVYLPFGN G--PRNCIGM 
Cyp3a25               YWPEPQEFCP ERFSKENK-- -------GNI DPYIYMPFGN G--PRNCIGM 
Cyp3a57               YWPEPEDFCP ERFSKENK-- -------GNI DPYIYMPFGN G--PRNCIGM 
Cyp3a41               HWPEPEEFQP ERFSKENK-- -------GSI DPYLYMPFGI G--PRNCIGM 
Cyp3a44               HWPDPEEFQP ERFSKENK-- -------GSI DPYVYLPFGI G--PRNCIGM 
Cyp4a10               VWPNPEVFDP SRFAPD---- -------SPR HSHSFLPFSG G--ARNCIGK 
Cyp4a12               VWPNPEVFDP SRFAPG---- -------SSR HSHSFLPFSG G--ARNCIGK 
Cyp4a14               FWPNPKVFDP SRFAPD---- -------SSH HSHAYLPFSG G--SRNCIGK 
Cyp4a30               LRPNAEVFDP SRFAPG---- -------APR QTHAFLPFSA G--TRNCIGK 
Cyp4a29               AFDKPEVFDP SRFAMN---- -------SVQ HSHAFLPFSG G--SRNCIGK 
Cyp4b1                VWPDPEVFDP LRFSPENM-- -------TGR HPFAFMPFSA G--PRNCIGQ 
Cyp4f13               VWPDPEVYNP FRFDPENP-- -------QKR SPLAFIPFSA G--TRNCIGQ 
Cyp4f14               VWPDPEVYDP FRFDPENI-- -------KDS SPLAFIPFSA G--PRNCIGQ 
Cyp4f15               VWPDPEVYDP FRFDPENI-- -------KDR SPLAFIPFSA G--PRNCIGQ 
Cyp4f16               VWPDPEVYDP FRFDPENP-- -------QKR SPLAFIPFSA G--PRNCIGQ 
Cyp4f17               VWPDPEVYDP FRFDPENP-- -------QKR SPLAFIPFSA G--PRNCIGQ 
Cyp4f18               VWPDPEVYDP FRFDADNV-- -------KGR SPLAFIPFSA G--PRNCIGQ 
Cyp4f37               VWPDPEVYDP FRFDPENA-- -------HKR PPLAFIPFSA G--PRNCIGQ 
Cyp4f39               VWPDSKVYNP YRFDPDTP-- -------QQR SPLAFVPFSA G--PRNCIGQ 
Cyp4f40               VWRDPEVYDP FRFDPENI-- -------QAR SPLSFIPFSA G--PRNCIGQ 
Cyp4v3                YFPDPEEFRP ERFFPENS-- -------QGR HPYAYVPFSA G--PRNCIGQ 
Cyp4x1                VWNDPKVFDP LRFTKENS-- -------DQR HPCAFLPFSS G--PRNCIGQ 
Cyp5a1                HWPNPETFDP ERFTAEAR-- -------LQR RPFTYLPFGA G--PRSCLGV 
Cyp7a1                IYPDPLTFKY DRYLDESGKA KTTFYRNGNK LKYFYMPFGS G--ATICPGR 
Cyp7b1                IFDAPKEFRF DRFIED-GKK KSTFFKGGKR LKTYVMPFGL G--TSKCPGR 
Cyp8a1                IYTEPEVFKY NRFLNPDGSE KKDFYKDGKR LKNYNMPWGA G--HNQCLGK 
Cyp8b1                IHPEPTAFKY DRFLNPDGTR KVDFYKSGKK IHHYSMPWGS G--VSKCPGR 
Cyp11a1               FFPNPNKFDP TRWLEKSQ-- ---NT----- THFRYLGFGW G--VRQCLGR 
Cyp11b1               VFPRPERYMP QRWLERK--- ---------- RSFKHLAFGF G--VRQCLGR 
Cyp11b2               VFPRPERYMP QRWLERK--- ---------- RSFQHLAFGF G--VRQCLGR 
Cyp17                 EWDQPDRFMP ERFLDPTG-- -SHLIT---- PTPSYLPFGA G--PRSCIGE 
Cyp19                 -FPKPNEFTL ENFEKNVP-- ---------- -YRYFQPFGF G--PRGCAGK 
Cyp20                 TWPLPHRFDP DRFADE---- -------PVM KVFSSLGFSG ---TWECPEL 
Cyp21                 VWELPSKFWP DRFLEPG--- ---------- KNPRTPSFGC G--ARVCLGE 
Cyp24                 NFEDADKFRP ERWLEKEK-- ---KIN---- -PFAHLPFGV G--KRMCIGR 
Cyp26a1               FTNKE-EFNP DRFIVPHPE- -----DAS-- -RFSFIPFGG G--LRSCVGK 
Cyp26b1               FKDVN-VFDP DRFSQARSE- -----DK--D GRFHYLPFGG G--VRTCLGK 
Cyp26c1               YRSPPEGFDP ERFGVESGD- -----ARGSG GRFHYIPFGG G--ARSCLGQ 
Cyp27a1               VFPEPNSFQP HRWLRKKE-- ---ADNPGIL HPFGSVPFGY G--VRSCLGR 
Cyp27b1               QFPDPNSFNP ARWLGEGP-- ---TP----- HPFASLPFGF G--KRSCIGR 
Cyp39                 YFPEPESFKP ERWKEAN--- -----LDKYI FLDYFMAFGG G--KFQCPGR 
Cyp46                 YFEDPLTFNP DRFGPG---- -------APK PRFTYFPFSL G--HRSCIGQ 
Cyp51                 SWAERLDFNP DRYLQDN--- -----PAS-G EKFAYVPFGA G--RHRCVGE 
CYP1A1h               LWVNPSEFLP ERFLTPDG-- -AIDKV---- LSEKVIIFGM G--KRKCIGE 
CYP1A2h               LWEDPSEFRP ERFLTADGT- -AINKP---- LSEKMMLFGM G--KRRCIGE 
CYP1B1h               KWPNPENFDP ARFLDKDG-- -LINKD---- LTSRVMIFSV G--KRRCIGE 
CYP2A6                FFSNPQDFNP QHFLNEKG-- ---QFK---- KSDAFVPFSI G--KRNCFGE 
CYP2A7                FFSNPRDFNP QHFLGEKG-- ---QFK---- KRDAFVPFSI R--KRNCFGE 
CYP2A13               FFSNPQDCSP QHFLDEKG-- ---QFK---- KSDAFVPFSI G--KRYCFGE 
CYP2B6                YFEKPDAFNP DHFLDANG-- ---ALK---- KTEAFIPFSL G--KRICLGE 
CYP2C8                EFPNPNIFDP GHFLDKNG-- ---NFK---- KSDYFMPFSA G--KRICAGE 
CYP2C9                EFPNPEMFDP HHFLDEGG-- ---NFK---- KSKYFMPFSA G--KRICVGE 
CYP2C18               EFPNPEMFDP GHFLDKSG-- ---NFK---- KSDYFMPFSA G--KRMCMGE 
CYP2C19               EFPNPEMFDP RHFLDEGG-- ---NFK---- KSNYFMPFSA G--KRICVGE 
CYP2D6                VWEKPFRFHP EHFLDAQG-- ---HFV---- KPEAFLPFSA G--RRACLGE 
CYP2E1h               EFPDPEKFKP EHFLNENG-- ---KFK---- YSDYFKPFST G--KRVCAGE 
CYP2F1                QFLTPQEFNP EHFLDANQ-- ---SFK---- KSPAFMPFSA G--RRLCLGE 
CYP2G2P               YFRYPDAFYP QHFLDEQG-- ---RFK---- KNEAFVPFSS GRGKRICLGE 
CYP2J2                EWATPDTFNP DHFLE-NG-- ---QFK---- KREAFMPFSI G--KRACLGE 
CYP2R1h               YWRDPEVFHP ERFLDSSG-- ---YFA---- KKEALVPFSL G--RRHCLGE 
CYP2S1h               IFKHPEEFNP DRFLDADG-- ---RFR---- KHEAFLPFSL G--KRVCLGE 
CYP2T2P               QFKDPDCFNP TNFLDKG--- ---KFQ---- GNDAFMPFAP A--KQMCLGT 
CYP2U1h               IWEKPEDFYP NRFLDDQG-- ---QLI---- KKETFIPFGI G--KRVCMGE 
CYP3A4                YWTEPEKFLP ERFSKKNK-- -------DNI DPYTYTPFGS G--PRNCIGM 
CYP3A5                YWTEPEEFRP ERFSKK-K-- -------DSI DPYIYTPFGT G--PRNCIGM 
CYP3A7                YWTEPEKFLP ERFSKKNK-- -------DNI DPYIYTPFGS G--PRNCIGM 
CYP3A43               YWTEPEKFCP ERFSKKNK-- -------DSI DLYRYIPFGA G--PRNCIGM 
CYP4A11               VWPNPEVFDP SRFAPG---- -------SAQ HSHAFLPFSG G--SRNCIGK 
CYP4A22               VWPNLEVFDP SRFAPG---- -------SAQ HSHAFLPFSG G--SRNCIGK 
CYP4B1h               VWPDPEVFDS LRFSTENA-- -------SKR HPFAFMPFSA G--PRNCIGQ 
CYP4F2                VWPDPEVYDP FRFDPENI-- -------KER SPLAFIPFSA G--PRNCIGQ 
CYP4F3                VWPDPEVYDP FRFDPKNI-- -------KER SPLAFIPFSA G--PRNCIGQ 
CYP4F8                VWPDPEVYDP FRFDPENA-- -------QKR SPMAFIPFSA G--PRNCIGQ 
CYP4F11               VWPDPEVYDP FRFNQENI-- -------KER SPLAFIPFSA G--PRNCIGQ 
CYP4F12               VWPDPEVYDP FRFDPENS-- -------KGR SPLAFIPFSA G--PRNCIGQ 
CYP4F22               VWPDSKVYNP YRFDPDNP-- -------QQR SPLAYVPFSA G--PRNCIGQ 
CYP4F23P              VWPDPEVYDP FRFDPENL-- -------QKT SPLAFIPFSA V--PRNCIGQ 
CYP4V2                YFPNPEEFQP ERFFPENA-- -------QGR HPYAYVPFSA G--PRNCIGQ 
CYP4X1h               VWKNPKVFDP LRFSQENS-- -------DQR HPYAYLPFSA G--SRNCIGQ 
CYP4Z1                FWEDPQVFNP LRFSRENS-- -------EKI HPYAFIPFSA G--PRNCIGQ 
CYP5A1h               HWPSPETFNP ERFTAEAR-- -------QQH RPFTYLPFGA G--PRSCLGV 
CYP7A1h               IYPDPLTFKY DRYLDENGKT KTTFYCNGLK LKYYYMPFGS G--ATICPGR 
CYP7B1h               IFEAPEEFRY DRFIED-GKK KTTFFKRGKK LKCYLMPFGT G--TSKCPGR 
CYP8A1h               IYTDPEVFKY NRFLNPDGSE KKDFYKDGKR LKNYNMPWGA G--HNHCLGR 
CYP8B1h               IHPEPTVFKY DRFLNPNGSR KVDFFKTGKK IHHYTMPWGS G--VSICPGR 
CYP11A1h              FFFDPENFDP TRWLSKDK-- ---NI----- TYFRNLGFGW G--VRQCLGR 
CYP11B1h              LFPRPERYNP QRWLDIRG-- ---SG----- RNFYHVPFGF G--MRQCLGR 
CYP11B2h              LFPRPERYNP QRWLDIRG-- ---SG----- RNFHHVPFGF G--MRQCLGR 
CYP17h                EWHQPDQFMP ERFLNPAG-- -TQLIS---- PSVSYLPFGA G--PRSCIGE 
CYP19h                -FPKPNEFTL ENFAKNVP-- ---------- -YRYFQPFGF G--PRGCAGK 
CYP20h                TWPSPHKFDP DRFDDE---- -------LVM KTFSSLGFSG ---TQECPEL 
CYP21A2h              VWERPHEFWP DRFLEPG--- ---------- KNSRALAFGC G--ARVCLGE 
CYP24h                NFEDSSQFRP ERWLQEKE-- ---KIN---- -PFAHLPFGV G--KRMCIGR 
CYP26A1h              FTNKE-EFNP DRFMLPHPE- -----DAS-- -RFSFIPFGG G--LRSCVGK 
CYP26B1h              FKDVN-VFDP DRFSQARSE- -----DK--D GRFHYLPFGG G--VRTCLGK 
CYP26C1h              YRSPPEGFDP ERFGAARED- -----SRGAS SRLHYIPFGG G--ARSCLGQ 
CYP27A1h              AFSEPESFQP HRWLRNSQ-- ---PATPRIQ HPFGSVPFGY G--VRACLGR 
CYP27B1h              QFPEPNSFRP ARWLGEGP-- ---TP----- HPFASLPFGF G--KRSCMGR 
CYP27C1h              NFPRAKEFRP ERWLRKGD-- ---LDR---V DNFGSIPFGH G--VRSCIGR 
CYP39A1h              YFPEPELFKP ERWKKAN--- -----LEKHS FLDCFMAFGS G--KFQCPAR 
CYP46h                YFEDPLTFNP DRFGPG---- -------APK PRFTYFPFSL G--HRSCIGQ 
CYP51h                SWVERLDFNP DRYLQDN--- -----PAS-G EKFAYVPFGA G--RHRCIGE 

Cyp1a1                TIGRSEVFLF LAILLQQIEF KVSPG----E KVDMT----- ---------- 
Cyp1a2                IPAKWEVFLF LAILLQHLEF SVPPG----V KVDLT----- ---------- 
Cyp1b1                ELSKMLLFLF ISILAHQCNF KANQN----E SSNMS----- ---------- 
Cyp2a4                GLARMELFLF LTNIMQNFHF KSTQA---PQ DIDVS----- ---------- 
Cyp2a5                GLARMELFLF LTNIMQNFHF KSTQA---PQ DIDVS----- ---------- 
Cyp2a12               SLAKMELFFL FTTILQNFRF KFPRK---LE DINES----- ---------- 
Cyp2b9                SIARNELFIF FTTILQNFSV ASPVA---PK DIDLT----- ---------- 
Cyp2b10               SIARNELFLF FTSILQNFSV ASHVA---PK DIDLT----- ---------- 
Cyp2b13               SIARNELFLF FTSILQNFSV ASPVA---SK DIDLT----- ---------- 
Cyp2b19               GIARNELFLF FTTILQNFSL ASPVA---PE NIDLI----- ---------- 
Cyp2b23               GIARNELFLF FTALLQNFSL SSPVA---PE DIDLT----- ---------- 
Cyp2c29               GLARMELFLI LTTILQNFKL KSLVH---PK EIDIT----- ---------- 
Cyp2c37               GLARMELFLF LTSILQSFNL KPLVH---PK DIDVT----- ---------- 
Cyp2c38               GLARMELFLI LTTILQNFKL KSLVH---PK DIDMM----- ---------- 
Cyp2c39               GLARMELFLF LTTILQNFKL KPLVH---PK DIDMI----- ---------- 
Cyp2c40               SLARMELFLF LTTILQNFKL KPLVD---PK DIDMT----- ---------- 
Cyp2c44               GLARMELFLF FTTILQKFSL KALVE---PK DLDIK----- ---------- 
Cyp2c50               GLARMELFLF LTSILQNFNL KPLVH---PK DIDVT----- ---------- 
Cyp2c54               GLARMELFLF LTSILQNFNL KPLVH---PK DIDIT----- ---------- 
Cyp2c55               ALARTELFLI LTTILQNFNL KSLVD---TK DIDTT----- ---------- 
Cyp2c65               GLARAELFLF LTTILQNFNL KSPVD---LK DLDTT----- ---------- 
Cyp2c66               GLARTELFLF LTTILQNFNL KSPVD---LK DLDTT----- ---------- 
Cyp2c67               SLARMELFLF LTTILQNFKL KPLVD---PK DIDMT----- ---------- 
Cyp2c68               ---------- ---------- ---------- ---------- ---------- 
Cyp2c69               SLARMELFLF LTTILQNFKL KPLVD---PK DIDTT----- ---------- 
Cyp2c70               GLARMEMFLI LTNILQHFTL KPLVK---PE DIDTK----- ---------- 
Cyp2d9                ALARMELFLF FTCLLQRFSF SVPDG---QP QPSNS----- ---------- 
Cyp2d10               PLARMELFLF FTCLLQHFSF SVPNG---QP RPRNL----- ---------- 
Cyp2d11               ALARMELFLF FTCLLQRFSI SVPDG---QP QPSNY----- ---------- 
Cyp2d12               PLARMELFLF FTCLLQRFSF SVPDG---QP QPSDH----- ---------- 
Cyp2d13               PLARMELFLF FTCLLQRFSF LVPAG---QP QPSDY----- ---------- 
Cyp2d22               PLARMELFLF FTCLLQRFSI SVPDG---QP QPSDH----- ---------- 
Cyp2d26               PLARMELFLF FTCLLQRFSF SVPDG---QP RPSDY----- ---------- 
Cyp2e1                GLARMELFLL LSAILQHFNL KSLVD---PK DIDLS----- ---------- 
Cyp2f2                PLARMELFIY FTSILQNFTL QPLVD---PE DIDLT----- ---------- 
Cyp2g1                ALARMELFLY FTSILQRFSL RSLVP---PA DIDIA----- ---------- 
Cyp2j5                QLAKSELFIF FSALMQKFTF KPPIN----E KLSLK----- ---------- 
Cyp2j6                QLARSELFIF FTSLMQKFTF NPPIN----E KLSPK----- ---------- 
Cyp2j7                QLARTELFIF FTALMQKFTF KAPVN----E KLSLK----- ---------- 
Cyp2j8                QLARSELFTF FTALMQKFTF KPPIN----E KLSLN----- ---------- 
Cyp2j9                QLARSELFIF ITTLFQKFTF KPPVN----E KLSLQ----- ---------- 
Cyp2j13               QLARSELFIF FTALVQKFTF KPPAN----E NLSLK----- ---------- 
Cyp2j12               QLARSELFIF FTALMQKFTF KPPIN----E KLSLK----- ---------- 
cyp2j11               QLASCELFIF FTALMQKFTF KSPIN----E KPSLK----- ---------- 
Cyp2r1                QLARMEMFLF FTSLLQQFHL HFPHE----L VPNLK----- ---------- 
Cyp2s1                GLARAELWLF FTSILQAFSL ETPCP---PG DLSLK----- ---------- 
Cyp2t4                GLARSEIFLF LTAILQKFSL LPVGS---PA NINLN----- ---------- 
Cyp2U1                ---------- ---------- ---------- ---------- ---------- 
Cyp2w1                SLARTELFLL FAGLLQRYRL LPPPG---LS PADLDLR--- ---------- 
CYP2W1h               RLARTELFLL FAGLLQRYRL LPPPG---VS PASLDTT--- ---------- 
Cyp3a11               RFALMNMKLA LTKIMQNFSF QPCKE---TQ IPLKLSR--- ---------- 
Cyp3a13               RFALINMKVA LVRVLQNFTV QPCKE---TE IPLKLSK--- ---------- 
Cyp3a16               RFALMNMKLA LIKVLQNFSF QPCKE---TQ IPLKLSR--- ---------- 
Cyp3a25               RFALISIKLA VIGVLQNFTV QPCEE---TQ IPLKISR--- ---------- 
Cyp3a57               RFALISVKLA VTGVLQNFTV QPCEE---TQ IPVKISR--- ---------- 
Cyp3a41               RFAFMTMKLA LTKVMQNFSF QPCQE---TQ IPLKLSR--- ---------- 
Cyp3a44               RFALMNMKLA VTKVLQNFSF QPCQE---TQ IPLKLSR--- ---------- 
Cyp4a10               QFAMSELKVI VALTLLRFEL LPDPT---RV PMPLA----- ---------- 
Cyp4a12               QFAMNELKVA VALTLLRFEL LPDPT---RV PIPIP----- ---------- 
Cyp4a14               QFAMNELKVA VALTLLRFEL LPDPT---RI PVPIA----- ---------- 
Cyp4a30               QFTMNELKVA VALTLLRFEL LPDPT---RV PILVS----- ---------- 
Cyp4a29               HLAMNVLKVA VALTLLRFEL LPDPS---RV PIPTQ----- ---------- 
Cyp4b1                QFAMNEMKVV TALCLLRFEF SPDPS---KI PIKVP----- ---------- 
Cyp4f13               TFAMSEIKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4f14               TFAMSEMKVA LALTLLRFRL LPD-D---KE PRRQP----- ---------- 
Cyp4f15               TFAMNEMKVA LALTLLRFRV LPD-D---KE PRRKP----- ---------- 
Cyp4f16               TFAMSEMKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4f17               TFAMREMKVA LALTLLRFRV LPG-D---KE PRRKP----- ---------- 
Cyp4f18               TFAMSEMKVA LALTLLRFRV LPD-D---KE PRRKP----- ---------- 
Cyp4f37               TFAMNEMMVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4f39               SFAMAEMRVV VALTLLRFRL SVDRT---HK VRRKP----- ---------- 
Cyp4f40               TFAMSEMKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4v3                KFAVMEEKTI LACILRQFWV ESNQK---RE ELGLAG---- ---------- 
Cyp4x1                QFAMLELKVA IALILLHFQV APDLT---RP PAFSS----- ---------- 
Cyp5a1                RLGLLVVKLT ILQVLHKFRF EASPE---TQ VPLQLES--- ---------- 
Cyp7a1                LFAVQEIKQF LILMLSYFEL ELVESHTKCP PLDQS----- ---------- 
Cyp7b1                YFAVNEMKLL LIELLTYFDL EIID--RKPI GLNHS----- ---------- 
Cyp8a1                SYAINSIKQF VVLLLTHFDL ELGSEDTEVP EFDLS----- ---------- 
Cyp8b1                FFALSEMKTF VLLMIMYFDF KLVDPDIPVP PIDPR----- ---------- 
Cyp11a1               RIAELEMTIL LINLLENFRI EVQN----LR DVGTK----- ---------- 
Cyp11b1               RLAEAEMMLL LHHVLKSFHV ETQE----KE DVRMA----- ---------- 
Cyp11b2               RLAEVEMMLL LHHILKTFQV ETLR----QE DVQMA----- ---------- 
Cyp17                 ALARQELFIF MALLLQRFDF DVSDD---KQ LPCLV----- ---------- 
Cyp19                 YIAMVMMKVV LVTLLRRFQV KTLQK---RC IENIP----- ---------- 
Cyp20                 XFAYMVTAVL VSVLLEKLRL LAVDR---QV VEMKY----- ---------- 
Cyp21                 PLARLELFVV LARLLQAFTL LPPPD---GT LPSLQ----- ---------- 
Cyp24                 RLAELQLHLA LCWIIQKYNI VATD----SE PVEML----- ---------- 
Cyp26a1               EFAKILLKIF TVELARHCDW QLLN---GPP TMKTS----- ---------- 
Cyp26b1               HLAKLFLKVL AVELASTSRF ELATR--TFP RITLV----- ---------- 
Cyp26c1               ELAQAVLQLL AVELVRTARW ELATP--AFP VMQTV----- ---------- 
Cyp27a1               RIAELEMQLM LSRLVQKYEI ALAPG---MG EVKTV----- ---------- 
Cyp27b1               RLAELELQMA LSQILTHFEV LPEPG---AL PIKPM----- ---------- 
Cyp39                 WFALLEIQLC IILVLYKYEC SLLDP--LPK QS--S----- ---------- 
Cyp46                 QFAQMEVKVV MAKLLQRIEF RLVPG---QR FGLQE----- ---------- 
Cyp51                 NFAYVQIKTI WSTMLRLYEF DLING--YFP TVN------- ---------- 
CYP1A1h               TIARWEVFLF LAILLQRVEF SVPLG----V KVDMT----- ---------- 
CYP1A2h               VLAKWEIFLF LAILLQQLEF SVPPG----V KVDLT----- ---------- 
CYP1B1h               ELSKMQLFLF ISILAHQCDF RANPN----E PAKMN----- ---------- 
CYP2A6                GLARMELFLF FTTVMQNFRL KSSQS---PK DIDVS----- ---------- 
CYP2A7                GLARMELFLF FTTVMQNFRL KSSQS---PK DIDVS----- ---------- 
CYP2A13               GLARMELFLF FTTIMQNFRF KSPQS---PK DIDVS----- ---------- 
CYP2B6                GIARAELFLF FTTILQNFSM ASPVA---PE DIDLT----- ---------- 
CYP2C8                GLARMELFLF LTTILQNFNL KSVDD---LK NLNTT----- ---------- 
CYP2C9                ALAGMELFLF LTSILQNFNL KSLVD---PK NLDTT----- ---------- 
CYP2C18               GLARMELFLF LTTILQNFNL KSQVD---PK DIDIT----- ---------- 
CYP2C19               GLARMELFLF LTFILQNFNL KSLID---PK DLDTT----- ---------- 
CYP2D6                PLARMELFLF FTSLLQHFSF SVPTG---QP RPSHH----- ---------- 
CYP2E1h               GLARMELFLL LCAILQHFNL KPLVD---PK DIDLS----- ---------- 
CYP2F1                LLARMELFLY LTAILQSFSL QPLGA---PE DIDLT----- ---------- 
CYP2G2P               AMDRMELFLY FTSTLQNFSL HSLVP---PV DIDIT----- ---------- 
CYP2J2                QLARTELFIF FTSLMQKFTF RPPNN----E KLSLK----- ---------- 
CYP2R1h               HLARMEMFLF FTALLQRFHL HFPHE----L VPDLK----- ---------- 
CYP2S1h               GLAKAEVFLF FTTILQAFSL ESPCP---PD TLSLK----- ---------- 
CYP2T2P               GLAHSGIFLF LTATLQRFCL LPVVR---PG TINLT----- ---------- 
CYP2U1h               QLAKMELFLM FVSLMQSFAF ALPED---SK KPLLT----- ---------- 
CYP3A4                RFALMNMKLA LIRVLQNFSF KPCKE---TQ IPLKLSL--- ---------- 
CYP3A5                RFALMNMKLA LIRVLQNFSF KPCKE---TQ IPLKLDT--- ---------- 
CYP3A7                RFALVNMKLA LVRVLQNFSF KPCKE---TQ IPLKLRF--- ---------- 
CYP3A43               RFALTNIKLA VIRALQNFSF KPCKE---TQ IPLKLDN--- ---------- 
CYP4A11               QFAMNELKVA TALTLLRFEL LPDPT---RI PIPIA----- ---------- 
CYP4A22               QFAMNQLKVA RALTLLRFEL LPDPT---RI PIPMA----- ---------- 
CYP4B1h               QFAMSEMKVV TAMCLLRFEF SLDPS---RL PIKMP----- ---------- 
CYP4F2                TFAMAEMKVV LALTLLAFRV LPD-H---TE PRRKP----- ---------- 
CYP4F3                AFAMAEMKVV LGLTLLAFRV LPD-H---TE PRRKP----- ---------- 
CYP4F8                KFAMAEMKVV LALTLLRFRI LPD-H---RE PRRTP----- ---------- 
CYP4F11               AFAMAEMKVV LALTLLHFRI LPT-H---IE PRRKP----- ---------- 
CYP4F12               AFAMAEMKVV LALMLLHFRF LPD-H---TE PRRKL----- ---------- 
CYP4F22               SFAMAELRVV VALTLLRFRL SVDRT---RK VRRKP----- ---------- 
CYP4F23P              TFAMAEMKVV LALTLLRFRV LPD-H---AE PRRKL----- ---------- 
CYP4V2                KFAVMEEKTI LSCILRHFWI ESNQK---RE ELGLEG---- ---------- 
CYP4X1h               EFAMIELKVT IALILLHFRV TPDPT---RP LTFPN----- ---------- 
CYP4Z1                HFAIIECKVA VALTLLRFKL APDHS---RP PQPVR----- ---------- 
CYP5A1h               RLGLLEVKLT LLHVLHKFRF QACPE---TQ VPLQLES--- ---------- 
CYP7A1h               LFAIHEIKQF LILMLSYFEL ELIEGQAKCP PLDQS----- ---------- 
CYP7B1h               FFALMEIKQL LVILLTYFDL EIID--DKPI GLNYS----- ---------- 
CYP8A1h               SYAVNSIKQF VFLVLVHLDL ELINADVEIP EFDLS----- ---------- 
CYP8B1h               FFALSEVKLF ILLMVTHFDL ELVDPDTPLP HVDPQ----- ---------- 
CYP11A1h              RIAELEMTIF LINMLENFRV EIQH----LS DVGTT----- ---------- 
CYP11B1h              RLAEAEMLLL LHHVLKHLQV ETLT----QE DIKMV----- ---------- 
CYP11B2h              RLAEAEMLLL LHHVLKHFLV ETLT----QE DIKMV----- ---------- 
CYP17h                ILARQELFLI MAWLLQRFDL EVPDD---GQ LPSLE----- ---------- 
CYP19h                YIAMVMMKAI LVTLLRRFHV KTLQG---QC VESIQ----- ---------- 
CYP20h                RFAYMVTTVL LSVLVKRLHL LSVEG---QV IETKY----- ---------- 
CYP21A2h              PLARLELFVV LTRLLQAFTL LPSGD----A LPSLQ----- ---------- 
CYP24h                RLAELQLHLA LCWIVRKYDI QATD----NE PVEML----- ---------- 
CYP26A1h              EFAKILLKIF TVELARHCDW QLLN---GPP TMKTS----- ---------- 
CYP26B1h              HLAKLFLKVL AVELASTSRF ELATR--TFP RITLV----- ---------- 
CYP26C1h              ELAQAVLQLL AVELVRTARW ELATP--AFP AMQTV----- ---------- 
CYP27A1h              RIAELEMQLL LARLIQKYKV VLAPE---TG ELKSV----- ---------- 
CYP27B1h              RLAELELQMA LAQILTHFEV QPEPG---AA PVRPK----- ---------- 
CYP27C1h              RIAELEIHLV VIQLLQHFEI KTSSQ---TN AVHAK----- ---------- 
CYP39A1h              WFALLEVQMC IILILYKYDC SLLDP--LPK QS--Y----- ---------- 
CYP46h                QFAQMEVKVV MAKLLQRLEF RLVPG---QR FGLQE----- ---------- 
CYP51h                NFAYVQIKTI WSTMLRLYEF DLIDG--YFP TVN------- ---------- 

Cyp1a1                ---------- ---------- -----PTYGL TLKHARCEHF QVQMRSSGPQ 
Cyp1a2                ---------- ---------- -----PNYGL TMKPGTCEHV QAWPRFSK-- 
Cyp1b1                ---------- ---------- -----FSYGL TIKPKSFRIH VSLRESMELL 
Cyp2a4                ---------- ---------- ----PRLVGF VTIPPTYTMS FLSR------ 
Cyp2a5                ---------- ---------- ----PRLVGF ATIPPTYTMS FLSR------ 
Cyp2a12               ---------- ---------- ----PTPEGF TRIIPKYTMS FVPI------ 
Cyp2b9                ---------- ---------- ----PKESGI GKIPPAHQIY FLAR------ 
Cyp2b10               ---------- ---------- ----PKESGI GKIPPTYQIC FLAR------ 
Cyp2b13               ---------- ---------- ----PKESGI GKIPPTYQIC FLAR------ 
Cyp2b19               ---------- ---------- ----PNNSGA TKTPPQYQIH FLSR------ 
Cyp2b23               ---------- ---------- ----PKESGF VKIPPVYRIC FLPR------ 
Cyp2c29               ---------- ---------- ----PVMNGF ASLPPPYQLC FIPL------ 
Cyp2c37               ---------- ---------- ----PMLIGL GSVPPAFQLC FIPS------ 
Cyp2c38               ---------- ---------- ----PFVNGL IALPPHYQLC FIPL------ 
Cyp2c39               ---------- ---------- ----PFVNGL IALPPHYQVC IIPR------ 
Cyp2c40               ---------- ---------- ----PKHSGF SKIPPNFQMC FIPVE----- 
Cyp2c44               ---------- ---------- ----PVTTGL FNLPPPYKLR LVPR------ 
Cyp2c50               ---------- ---------- ----PMLIGL ASVPPAFQLC FIPS------ 
Cyp2c54               ---------- ---------- ----PMLIGL GSVPPAFQLC FIPS------ 
Cyp2c55               ---------- ---------- ----PVANTF GRVPPSYQLY FIPR------ 
Cyp2c65               ---------- ---------- ----PVANGF ASVPPKFQIC FIPI------ 
Cyp2c66               ---------- ---------- ----PVANGF VSVPPKFQIC FISI------ 
Cyp2c67               ---------- ---------- ----PKHSGF SKIPPNFQMC FIPVE----- 
Cyp2c68               ---------- ---------- ---------- ---------- ---------- 
Cyp2c69               ---------- ---------- ----PKYSGF SKIPPKFQMC FIPVE----- 
Cyp2c70               ---------- ---------- ----PVQTGL LHVPPPFELC FIPV------ 
Cyp2d9                ---------- ---------- -----GVYGI LVAPSPYQLC AVVRDQGH-- 
Cyp2d10               ---------- ---------- -----GVFPF PVAPYPYQLC AVMREQGH-- 
Cyp2d11               ---------- ---------- -----RVHAI PVAPFPYQLC AVMHEQGH-- 
Cyp2d12               ---------- ---------- -----RVFFI MVAPSPYQLC AVIREQGH-- 
Cyp2d13               ---------- ---------- -----GIFTF LVSPSPYQLC AFTRDQATN- 
Cyp2d22               ---------- ---------- -----GVFRA LTTPCPYQLC ALPR------ 
Cyp2d26               ---------- ---------- -----GIYTM PVTPEPYQLC AVAR------ 
Cyp2e1                ---------- ---------- ----PVTIGF GSIPREFKLC VIPRS----- 
Cyp2f2                ---------- ---------- ----PLSSGL GNLPRPFQLC MHIR------ 
Cyp2g1                ---------- ---------- ----HKISGF GNIPPVYELC FMAR------ 
Cyp2j5                ---------- ---------- -----FRMGL ILSPASYRIC AIPRV----- 
Cyp2j6                ---------- ---------- -----FRNGL TLSPVSHRIC AVPRQ----- 
Cyp2j7                ---------- ---------- -----FRMSV PISPVSYCIC AVPRQ----- 
Cyp2j8                ---------- ---------- -----FKMGV ALSPVSYCIC AVPR------ 
Cyp2j9                ---------- ---------- -----FRMAA TVSPVSHRLC AIPRL----- 
Cyp2j13               ---------- ---------- -----FRLGI TISPVSYRIG AVPRQ----- 
Cyp2j12               ---------- ---------- -----FRNGL TLSPVSHCIC AVPRH----- 
cyp2j11               ---------- ---------- -----FRMGL TLAPVSYRIC AVPRL----- 
Cyp2r1                ---------- ---------- -----PRLGM TLQPQPYLIC AERR------ 
Cyp2s1                ---------- ---------- ----PAISGL FNIPPDFQLR VWPTGDQSR- 
Cyp2t4                ---------- ---------- ----PQCTGL GNVPPAFQLR LVAR------ 
Cyp2U1                ---------- ---------- ---------- ---------- ---------- 
Cyp2w1                ---------- ---------- -----PAPAF TMRPPAQ--- ---------- 
CYP2W1h               ---------- ---------- -----PARAF TMRPRAQALC AVPRP----- 
Cyp3a11               ---------- ---------- -------QGL LQPEKPIVLK VVPRDAVITG 
Cyp3a13               ---------- ---------- -------QGL LQPENPLLLK VVSRDETVSD 
Cyp3a16               ---------- ---------- -------ELL LQPVKPIVLK VVPRDAVITG 
Cyp3a25               ---------- ---------- -------EPI FQPEKPIILK VVSRDKPRTG 
Cyp3a57               ---------- ---------- -------QPI FRPEKPIILK FVSRDKPRTG 
Cyp3a41               ---------- ---------- -------QGL LQPEKPIVLK VVPRDVVITG 
Cyp3a44               ---------- ---------- -------QGI LQPEKPIVLK VVPRDAVITG 
Cyp4a10               ---------- ---------- -------RLV LKSKNGIYLH LKKLH----- 
Cyp4a12               ---------- ---------- -------RIV LKSKNGIHLH LKKLQ----- 
Cyp4a14               ---------- ---------- -------RLV LKSKNGIHLC LKKLR----- 
Cyp4a30               ---------- ---------- -------KIV LKSKNGIYLH TKKL------ 
Cyp4a29               ---------- ---------- -------QLV LKSKNGIYLH LRKL------ 
Cyp4b1                ---------- ---------- -------QLI LRSKNGIHLY LKPLGPGSGK 
Cyp4f13               ---------- ---------- -------ELI LRAEGGLWLR VEPLSAGAQ- 
Cyp4f14               ---------- ---------- -------ELI LRAEGGLWLR VEPLSAGAH- 
Cyp4f15               ---------- ---------- -------ELI LRAEGGLWLR VEPLSTQ--- 
Cyp4f16               ---------- ---------- -------EII LRAEGGLWLR VEPLSKGAQ- 
Cyp4f17               ---------- ---------- -------ELI LRAEGGLWLR VEPLSKGTQ- 
Cyp4f18               ---------- ---------- -------ELI LRAEGGLWLK VEPLSAGAQ- 
Cyp4f37               ---------- ---------- -------EII LRAEGGLWLR VEPLS----- 
Cyp4f39               ---------- ---------- -------ELI LRTENGLWLN VEPLPSRA-- 
Cyp4f40               ---------- ---------- -------ELI LRAEGGLWLR VEPLSTQA-- 
Cyp4v3                ---------- ---------- -------DLI LRPNNGIWIK LKRRHEDDP- 
Cyp4x1                ---------- ---------- -------HTV LRPKHGIYLH LKKL------ 
Cyp5a1                ---------- ---------- -------KSA LGPKNGVYIK IVSR------ 
Cyp7a1                ---------- ---------- ----RAGLGI LPPLNDIEFK YKLKH----- 
Cyp7b1                ---------- ---------- ----RMFLGI QHPDSAVSFR YKAKSWRS-- 
Cyp8a1                ---------- ---------- ----RYGFGL MQPEEDVPIR YRARL----- 
Cyp8b1                ---------- ---------- ----RWGFGT SQPSHEVRFL YRLKPVQ--- 
Cyp11a1               ---------- ---------- ------FSLI LMPENPILFN FQPLKQDLGP 
Cyp11b1               ---------- ---------- ------YRFV LMPSSSPLLT FRPVN----- 
Cyp11b2               ---------- ---------- ------YRFV LMPSSSPVLT FRPVS----- 
Cyp17                 ----G----- ---------- ----DPKVVF LIDPFKVKIT VRQAWKDAQV 
Cyp19                 ---------- ----K-KN-- ----DLSLHP NEDRHLVEII FSPRNSDKYL 
Cyp20                 ---------- ---------- -------ELV TSAREEAWIT VSKRH----- 
Cyp21                 ----P----- ---------- ----QPYAGI NLPIPPFQVR LQPRNLAPQD 
Cyp24                 ---------- ---------- ------HLGI LVPSRELPIA FCPR------ 
Cyp26a1               ---------- ---------- ----PTVYPV DNLPARFTYF QGDI------ 
Cyp26b1               ---------- ---------- ----PVLHPV DGLSVKFFGL DSNQNEILPE 
Cyp26c1               ---------- ---------- ----PIVHPV DGLLLFFHPL PTSGAGDGLP 
Cyp27a1               ---------- ---------- ------SRIV LVPSKKVRLH FLQRQ----- 
Cyp27b1               ---------- ---------- ------TRTV LVPERSINLQ FVDR------ 
Cyp39                 ---------- ---------- ----RHLVGV PQPAGKCRIE YKQRA----- 
Cyp46                 ---------- ---------- -------QAT LKPLDPVLCT LRPRGWQPAP 
Cyp51                 ---------- ---------- -----YTTMI HTPENPVIRY KRRSK----- 
CYP1A1h               ---------- ---------- -----PIYGL TMKHACCEHF QMQLRS---- 
CYP1A2h               ---------- ---------- -----PIYGL TMKHARCEHV QARRFSIN-- 
CYP1B1h               ---------- ---------- -----FSYGL TIKPKSFKVN VTLRESMELL 
CYP2A6                ---------- ---------- ----PKHVGF ATIPRNYTMS FLPR------ 
CYP2A7                ---------- ---------- ----PKHVVF ATIPRNYTMS FLPR------ 
CYP2A13               ---------- ---------- ----PKHVGF ATIPRNYTMS FLPR------ 
CYP2B6                ---------- ---------- ----PQECGV GKIPPTYQIR FLPR------ 
CYP2C8                ---------- ---------- ----AVTKGI VSLPPSYQIC FIPV------ 
CYP2C9                ---------- ---------- ----PVVNGF ASVPPFYQLC FIPV------ 
CYP2C18               ---------- ---------- ----PIANAF GRVPPLYQLC FIPV------ 
CYP2C19               ---------- ---------- ----PVVNGF ASVPPFYQLC FIPV------ 
CYP2D6                ---------- ---------- -----GVFAF LVSPSPYELC AVPR------ 
CYP2E1h               ---------- ---------- ----PIHIGF GCIPPRYKLC VIPRS----- 
CYP2F1                ---------- ---------- ----PLSSGL GNLPRPFQLC LRPR------ 
CYP2G2P               ---------- ---------- ----PKLSGF GNIPPTYELC LVAR------ 
CYP2J2                ---------- ---------- -----FRMGI TISPVSHRLC ---------- 
CYP2R1h               ---------- ---------- -----PRLGM TLQPQPYLIC AERR------ 
CYP2S1h               ---------- ---------- ----PTVSGL FNIPPAFQLQ VRPTDLHSTT 
CYP2T2P               ---------- ---------- -----QCTGL GSVPPDFQLQ PVAC------ 
CYP2U1h               ---------- ---------- -----GRFGL TLAPHPFNIT ISRR------ 
CYP3A4                ---------- ---------- -------GGL LQPEKPVVLK VESRDGTVSG 
CYP3A5                ---------- ---------- -------QGL LQPEKPIVLK VDSRDGTLSG 
CYP3A7                ---------- ---------- -------GGL LLTEKPIVLK AESRDETVSG 
CYP3A43               ---------- ---------- -------LPI LQPEKPIVLK VHLRDGITSG 
CYP4A11               ---------- ---------- -------RLV LKSKNGIHLR LRRLPNPCED 
CYP4A22               ---------- ---------- -------RLV LKSKNGIHLR LRRLPNPCED 
CYP4B1h               ---------- ---------- -------QLV LRSKNGFHLH LKPLGPGSGK 
CYP4F2                ---------- ---------- -------ELV LRAEGGLWLR VEPLS----- 
CYP4F3                ---------- ---------- -------ELV LRAEGGLWLR VEPLS----- 
CYP4F8                ---------- ---------- -------EIV LRAEDGLWLR VEPLG----- 
CYP4F11               ---------- ---------- -------ELI LRAEGGLWLR VEPLGANSQ- 
CYP4F12               ---------- ---------- -------ELI MRAEGGLWLR VEPLNVGLQ- 
CYP4F22               ---------- ---------- -------ELI LRTENGLWLK VEPLPPRA-- 
CYP4F23P              ---------- ---------- -------ELI VRAEDGLWLR VEPLSADLQ- 
CYP4V2                ---------- ---------- -------QLI LRPSNGIWIK LKRRNADER- 
CYP4X1h               ---------- ---------- -------HFI LKPKNGMYLH LKKL------ 
CYP4Z1                ---------- ---------- -------QVV LKSKNGIHVF AKKV------ 
CYP5A1h               ---------- ---------- -------KSA LGPKNGVYIK IVSR------ 
CYP7A1h               ---------- ---------- ----RAGLGI LPPLNDIEFK YKFKHL---- 
CYP7B1h               ---------- ---------- ----RLLFGI QYPDSDVLFR YKVKS----- 
CYP8A1h               ---------- ---------- ----RYGFGL MQPEHDVPVR YRIRP----- 
CYP8B1h               ---------- ---------- ----RWGFGT MQPSHDVRFR YRLHPTE--- 
CYP11A1h              ---------- ---------- ------FNLI LMPEKPISFT FWPFNQEATQ 
CYP11B1h              ---------- ---------- ------YSFI LRPSMCPLLT FRAIN----- 
CYP11B2h              ---------- ---------- ------YSFI LRPGTSPLLT FRAIN----- 
CYP17h                ----G----- ---------- ----IPKVVF LIDSFKVKIK VRQAWREAQA 
CYP19h                ---------- ----K-IH-- ----DLSLHP DETKNMLEMI FTPRNSDRCL 
CYP20h                ---------- ---------- -------ELV TSSREEAWIT VSKRY----- 
CYP21A2h              ----P----- ---------- ----LPHCSV ILKMQPFQVR LQPRGMGAHS 
CYP24h                ---------- ---------- ------HSGT LVPSRELPIA FCQR------ 
CYP26A1h              ---------- ---------- ----PTVYPV DNLPARFTHF HGEI------ 
CYP26B1h              ---------- ---------- ----PVLHPV DGLSVKFFGL DSNQNEILPE 
CYP26C1h              ---------- ---------- ----PIVHPV DGLRLFFHPL TPSVAGNGLC 
CYP27A1h              ---------- ---------- ------ARIV LVPNKKVGLQ FLQRQC---- 
CYP27B1h              ---------- ---------- ------TRTV LVPERSINLQ FLDR------ 
CYP27C1h              ---------- ---------- ------THGL LTPGGPIHVR FVNRK----- 
CYP39A1h              ---------- ---------- ----LHLVGV PQPEGQCRIE YKQRI----- 
CYP46h                ---------- ---------- -------QAT LKPLDPVLCT LRPRGWQPAP 
CYP51h                ---------- ---------- -----YTTMI HTPENPVIRY KRRSK----- 

Cyp1a1                HLQA------ ----
Cyp1a2                ---------- ----
Cyp1b1                DNAVKKLQTE EGCK
Cyp2a4                ---------- ----
Cyp2a5                ---------- ----
Cyp2a12               ---------- ----
Cyp2b9                ---------- ----
Cyp2b10               ---------- ----
Cyp2b13               ---------- ----
Cyp2b19               ---------- ----
Cyp2b23               ---------- ----
Cyp2c29               ---------- ----
Cyp2c37               ---------- ----
Cyp2c38               ---------- ----
Cyp2c39               ---------- ----
Cyp2c40               ---------- ----
Cyp2c44               ---------- ----
Cyp2c50               ---------- ----
Cyp2c54               ---------- ----
Cyp2c55               ---------- ----
Cyp2c65               ---------- ----
Cyp2c66               ---------- ----
Cyp2c67               ---------- ----
Cyp2c68               ---------- ----
Cyp2c69               ---------- ----
Cyp2c70               ---------- ----
Cyp2d9                ---------- ----
Cyp2d10               ---------- ----
Cyp2d11               ---------- ----
Cyp2d12               ---------- ----
Cyp2d13               ---------- ----
Cyp2d22               ---------- ----
Cyp2d26               ---------- ----
Cyp2e1                ---------- ----
Cyp2f2                ---------- ----
Cyp2g1                ---------- ----
Cyp2j5                ---------- ----
Cyp2j6                ---------- ----
Cyp2j7                ---------- ----
Cyp2j8                ---------- ----
Cyp2j9                ---------- ----
Cyp2j13               ---------- ----
Cyp2j12               ---------- ----
cyp2j11               ---------- ----
Cyp2r1                ---------- ----
Cyp2s1                ---------- ----
Cyp2t4                ---------- ----
Cyp2U1                ---------- ----
Cyp2w1                ---------- ----
CYP2W1h               ---------- ----
Cyp3a11               A--------- ----
Cyp3a13               E--------- ----
Cyp3a16               A--------- ----
Cyp3a25               S--------- ----
Cyp3a57               P--------- ----
Cyp3a41               A--------- ----
Cyp3a44               A--------- ----
Cyp4a10               ---------- ----
Cyp4a12               ---------- ----
Cyp4a14               ---------- ----
Cyp4a30               ---------- ----
Cyp4a29               ---------- ----
Cyp4b1                ---------- ----
Cyp4f13               ---------- ----
Cyp4f14               ---------- ----
Cyp4f15               ---------- ----
Cyp4f16               ---------- ----
Cyp4f17               ---------- ----
Cyp4f18               ---------- ----
Cyp4f37               ---------- ----
Cyp4f39               ---------- ----
Cyp4f40               ---------- ----
Cyp4v3                ---------- ----
Cyp4x1                ---------- ----
Cyp5a1                ---------- ----
Cyp7a1                ---------- ----
Cyp7b1                ---------- ----
Cyp8a1                ---------- ----
Cyp8b1                ---------- ----
Cyp11a1               AVTRKDNTVN ----
Cyp11b1               ---------- ----
Cyp11b2               ---------- ----
Cyp17                 EVST------ ----
Cyp19                 QQ-------- ----
Cyp20                 ---------- ----
Cyp21                 QGERP----- ----
Cyp24                 ---------- ----
Cyp26a1               ---------- ----
Cyp26b1               TEAMLSATV- ----
Cyp26c1               F--------- ----
Cyp27a1               ---------- ----
Cyp27b1               ---------- ----
Cyp39                 ---------- ----
Cyp46                 PPPPC----- ----
Cyp51                 ---------- ----
CYP1A1h               ---------- ----
CYP1A2h               ---------- ----
CYP1B1h               DSAVQNLQAK ETCQ
CYP2A6                ---------- ----
CYP2A7                ---------- ----
CYP2A13               ---------- ----
CYP2B6                ---------- ----
CYP2C8                ---------- ----
CYP2C9                ---------- ----
CYP2C18               ---------- ----
CYP2C19               ---------- ----
CYP2D6                ---------- ----
CYP2E1h               ---------- ----
CYP2F1                ---------- ----
CYP2G2P               ---------- ----
CYP2J2                ---------- ----
CYP2R1h               ---------- ----
CYP2S1h               QTR------- ----
CYP2T2P               ---------- ----
CYP2U1h               ---------- ----
CYP3A4                A--------- ----
CYP3A5                E--------- ----
CYP3A7                A--------- ----
CYP3A43               P--------- ----
CYP4A11               KDQL------ ----
CYP4A22               KDQL------ ----
CYP4B1h               ---------- ----
CYP4F2                ---------- ----
CYP4F3                ---------- ----
CYP4F8                ---------- ----
CYP4F11               ---------- ----
CYP4F12               ---------- ----
CYP4F22               ---------- ----
CYP4F23P              ---------- ----
CYP4V2                ---------- ----
CYP4X1h               ---------- ----
CYP4Z1                ---------- ----
CYP5A1h               ---------- ----
CYP7A1h               ---------- ----
CYP7B1h               ---------- ----
CYP8A1h               ---------- ----
CYP8B1h               ---------- ----
CYP11A1h              Q--------- ----
CYP11B1h              ---------- ----
CYP11B2h              ---------- ----
CYP17h                EGST------ ----
CYP19h                EH-------- ----
CYP20h                ---------- ----
CYP21A2h              PGQNQ----- ----
CYP24h                ---------- ----
CYP26A1h              ---------- ----
CYP26B1h              TEAMLSATV- ----
CYP26C1h              L--------- ----
CYP27A1h              ---------- ----
CYP27B1h              ---------- ----
CYP27C1h              ---------- ----
CYP39A1h              ---------- ----
CYP46h                PPPPC----- ----
CYP51h                ---------- ----