ࡱ> )+$%&'( bjbjв 4к_к_`````tttt$ttttttttt      $w-~.`ttttt.``ttCt`t`tt` PY0`(ttttttt..ttttttttttttttttX &: 154 814 Cyp1a1 ---------- ---------- ---------M PSMYGLPAFV SATELLLAVT Cyp1a2 ---------- ---------- ---------- --MAFSQYIS LAPELLLATA Cyp1b1 ---------- ---------- --MATSLSAD SPQQLSSLST QQTTLLLLFS Cyp2a4 ---------- ---------- ---------- ----MLTSGL LLVAAVAFLS Cyp2a5 ---------- ---------- ---------- ----MLTSGL LLVAAVAFLS Cyp2a12 ---------- ---------- ---------- ----MLGSGL LLLAILAFLS Cyp2b9 ---------- ---------- ---------- ------MDPS VLLLLAVLLS Cyp2b10 ---------- ---------- ---------- ------MEPS VLLLLALLVG Cyp2b13 ---------- ---------- ---------- ------MDPS VLLLLAVLLS Cyp2b19 ---------- ---------- ---------- ------MEFS VLLLLALTTG Cyp2b23 ---------- ---------- ---------- ------MEPS VLLLLALLTG Cyp2c29 ---------- ---------- ---------- --------MD LVVFLALTLS Cyp2c37 ---------- ---------- ---------- --------MD PILVLVLTLS Cyp2c38 ---------- ---------- ---------- ---------D LVTFLVLTLS Cyp2c39 ---------- ---------- ---------- ---------D LVTFLVLTLS Cyp2c40 ---------- ---------- ---------- --------MD PFVVLVLCLS Cyp2c44 ---------- ---------- ---------- ----MELLGL PTLALLVLVM Cyp2c50 ---------- ---------- ---------- --------MD PILVLVFTLS Cyp2c54 ---------- ---------- ---------- --------MD PILVLVLTLS Cyp2c55 ---------- ---------- ---------- --------MD PVLVLVLTLS Cyp2c65 ---------- ---------- ---------- --------MV LGVFLGLLLT Cyp2c66 ---------- ---------- ---------- --------MV LGVFLGLLLT Cyp2c67 ---------- ---------- ---------- --------MD PFVVLVLCLS Cyp2c68 ---------- ---------- ---------- --------MD PFVVLVLCLS Cyp2c69 ---------- ---------- ---------- --------MD PFVVLVLCLS Cyp2c70 ---------- ---------- ---------- -----SESMA LFIFLGIWLS Cyp2d9 ---------- ---------- ---------- ------MELL TGTDLWPVA- Cyp2d10 ---------- ---------- ---------- ------MELL TGAGLWSVA- Cyp2d11 ---------- ---------- ---------- ------MELL TGAGLWSVA- Cyp2d12 ---------- ---------- ---------- ------MELL TGTDLWSVA- Cyp2d13 ---------- ---------- ---------- ------MELL TGTGLWPVA- Cyp2d22 ---------- ---------- ---------- ------MRLP TGAELWPIA- Cyp2d26 ---------- ---------- ---------- ------MGLL VGDDLWAVV- Cyp2e1 ---------- ---------- ---------- -----MAVLG ITVALLVWIA Cyp2f2 ---------- ---------- ---------- -------MDG VSTAILLLLL Cyp2g1 ---------- ---------- ---------- ----MMLGGA FSIFMALCLS Cyp2j5 ---------- ---------- ---------- ---MIMFLSS LVTTFWEALH Cyp2j6 ---------- ---------- ---------- ---MLAATGS LLATIWAALH Cyp2j7 ---------- ---------- ---------- ---MLSTVGS LVARIWSAIH Cyp2j8 ---------- ---------- ---------- ---MFATIGC LVSNICSEIH Cyp2j9 ---------- ---------- ---------- ---MLAAAGS LVAAIWAALH Cyp2j13 ---------- ---------- ---------- ---MLEAADS LAAAFWAALH Cyp2j12 ---------- ---------- ---------- ---MLATEDT FETAIWALLH cyp2j11 ---------- ---------- ---------- ---MLAIATC LVANICSATH Cyp2r1 ---------- ---------- ---------- -------MLE LPGARACAGA Cyp2s1 ---------- ---------- ---------- ------MEAA STWALLLALL Cyp2t4 ---------- ---------- ---------- --------MV TCLALLLLLL Cyp2U1 ---------- ---------- ---------- ---MSSLGDQ RPAAGEQPG- Cyp2w1 ---------- ---------- ---------- --MALLLLGV WGILLLLGLW CYP2W1h ---------- ---------- ---------- --MALLLL-- -LFLGLLGLW Cyp3a11 ---------- ---------- --------MD LVSALSLETW VLLAISLVLL Cyp3a13 ---------- ---------- --------MD LIPNFSMETW MLLATSLVLL Cyp3a16 ---------- ---------- --------MN LFSALSLDTL VLLAIILVLL Cyp3a25 ---------- ---------- --------ME LIPNLSIETW VLLVTSLVLF Cyp3a57 ---------- ---------- --------ME LIPNLSIQTW VLLVTSLVFF Cyp3a41 ---------- ---------- --------MN LFSALSLDTW VLLAIILVLL Cyp3a44 ---------- ---------- --------MN LFSALSLDTL VLLAIILVLL Cyp4a10 ---------- --------MS VSALSPTRFA DSLSGFLQVA SVLGLLLLLV Cyp4a12 ---------- --------MS ASALSSIRFP GSISEYLQVA SVLSLLLLLF Cyp4a14 ---------- --------MG FFLFSPTRYL DGISGFFQWA FLLSLFLVLF Cyp4a30 ---------- --------MS IFELSHITNV FGIFGLLQVV SLLGLLLLLL Cyp4a29 ---------- --------MS ISALSPIRFL ECVSGFLQVI FLIGLLLLLF Cyp4b1 ---------- ---------- ---MALSFLS PSLSRLGLWA SVVILMVTVL Cyp4f13 ---------- --------ML QLCLSWLGMG SLTASPWHLL LLGGASWILA Cyp4f14 ---------- --------MS QLSLSWLGLG PEVAFPWKTL LLLGASWILA Cyp4f15 ---------- ---MGFFRMP QLDLSWLGLR LEASSPWLLL LLIGASWLLA Cyp4f16 ---------- --------ML RLSVSGLDLG SVVTSSWHLL LLGVASWILA Cyp4f17 ---------- --------ML QLGLSWLGLG PGAAFPWQLL QLVGASLFLA Cyp4f18 ---------- --------MS QLSLSWMGLG HTAASPWLLL LLAGASCLLA Cyp4f37 ---------- --------ML RLSVSGLDLG SVVTLSWHLL LLGAASWILA Cyp4f39 ---------- MLPLTDYLLQ LLGLEKTAFR VYVVSALLLL VLFFFFRLLV Cyp4f40 ---------- --------MR YLDLSWLGLG PMSASPWLLF FLVGISWFLA Cyp4v3 ---------- --------ML WLWLGLSGQK LLLWGAASAV SLAGATILIS Cyp4x1 ---------- ---------- ---MEASWLE TRWARPLHLA LVFCLALVLM Cyp5a1 ---------- ---------- --MEVLGLLK FEVSGTIVTV TLLVALLALL Cyp7a1 ---------- ---------- ---------- ---MMSISLI WGIAVVVSCC Cyp7b1 ---------- ---------- ---MQGATTL DAASPGPLAL LGLLFAATLL Cyp8a1 ---------- ---------- ---------- ----MSWAAL LGLLAVLLL- Cyp8b1 ---------- ---------- ---------- ---MTLWCTV LGALLTVVG- Cyp11a1 ---------- ---------- -----MLAKG LSLRSVLVKG CQPFLSPTWQ Cyp11b1 ---------- ---------- ---------- ----MALRVT TDVWLARPWQ Cyp11b2 ---------- ---------- ---------- ----MALRVT ADVWLARPWQ Cyp17 ---------- ---------- ---------- ---MWELVGL LLLILAYFFW Cyp19 ---------- ---------- ---------- --MFLEMLNP MQYNVTIMVP Cyp20 ---------- ---------- -------MLD FAIFAVTFLL ALVGAVLYLY Cyp21 ---------- ---------- ---------- -------MLL PGLLLLLLLL Cyp24 ---------- ---------- ---------- ----MSCPID KRRPLIAFLR Cyp26a1 ---------- ---------- ---MGLPALL ASALCTFVLP LLLFLAALKL Cyp26b1 ---------- --------ML FEGLELVSAL ATLAACLVSV TLLLAVSQQL Cyp26c1 ---------- --------MI SWGLSCLSVL GAAGTTLLCA GLLLGLAQQL Cyp27a1 ---------- ---------- ---------- ------MAAW SRTRLRWTLL Cyp27b1 ---------- ---------- --------LE ADSPNTDMTQ AVKLASRVFH Cyp39 ---------- ---------- ---------- ----MGIMEL FSPIAIAVLG Cyp46 ---------- ---------- ------MSPG LLLLGSAVLL AFGLCCTFVH Cyp51 ---------- ---------- ---MEQVTGG NLLSTLLIAC AFTLSLVYLF CYP1A1h ---------- ---------- ---------- ---MLFPISM SATEFLLASV CYP1A2h ---------- ---------- ---------- -MALSQSVPF SATELLLASA CYP1B1h ---------- ---------- --MGTSLSPN DPWPLNPLSI QQTTLLLLLS CYP2A6 ---------- ---------- ---------- ----MLASGM LLVALLVCLT CYP2A7 ---------- ---------- ---------- ----MLASGL LLVALLACLT CYP2A13 ---------- ---------- ---------- ----MLASGL LLVTLLACLT CYP2B6 ---------- ---------- ---------- ------MELS VLLFLALLTG CYP2C8 ---------- ---------- ---------- --------ME PFVVLVLCLS CYP2C9 ---------- ---------- ---------- --------MD SLVVLVLCLS CYP2C18 ---------- ---------- ---------- --------MD PAVALVLCLS CYP2C19 ---------- ---------- ---------- --------MD PFVVLVLCLS CYP2D6 ---------- ---------- ---------- ---------M GLEALVPLA- CYP2E1h ---------- ---------- ---------- -----MSALG VTVALLVWAA CYP2F1 ---------- ---------- ---------- -------MDS ISTAILLLLL CYP2G2P ---------- ---------- ---------- ----MEMGGA VTIFLALCLS CYP2J2 ---------- ---------- ---------- ---MLAAMGS LAAALWAVVH CYP2R1h ---------- ---------- ---------- -------MWK LWRAEEGAAA CYP2S1h ---------- ---------- ---------- ------MEAT GTWALLLALA CYP2T2P ---------- ---------- ---------- ---------- ---------- CYP2U1h ---------- ---------- ---------- ---MSSPGPS QPPAEDPPWP CYP3A4 ---------- ---------- --------MA VIPDLAMETW LLLAVSLVLL CYP3A5 ---------- ---------- --------MD LIPNLAVETW LLLAVSLVLL CYP3A7 ---------- ---------- --------MD LIPNLAVETW LLLAVSLILL CYP3A43 ---------- ---------- --------MD LIPNFAMETW VLVATSLVLL CYP4A11 ---------- --------MS VSVLSPSRLL GDVSGILQAA SLLILLLLLI CYP4A22 ---------- --------MS VSVLSPSRRL GGVSGILQVT SLLILLLLLI CYP4B1h ---------- ---------- ---MVPSFLS LSFSSLGLWA SGLILVLGFL CYP4F2 ---------- --------MS QLSLSWLGLW PVAASPWLLL LLVGASWLLA CYP4F3 ---------- --------MP QLSLSSLGLW PMAASPWLLL LLVGASWLLA CYP4F8 ---------- --------MS LLSLSWLGLR PVAASPWLLL LVVGASWLLA CYP4F11 ---------- --------MP QLSLSWLGLG PVAASPWLLL LLVGGSWLLA CYP4F12 ---------- --------MS LLSLPWLGLR PVAMSPWLLL LLVVGSWLLA CYP4F22 ---------- MLPITDRLLH LLGLEKTAFR IYAVSTLLLF LLFFLFRLLL CYP4F23P ---------- --------MS LLSLSWLGLG PVAASPWLLL LLVGASWLLA CYP4V2 ---------- --------MA GLWLGLVWQK LLLWGAASAV SLAGASLVLS CYP4X1h ---------- ---------- ---MEFSWLE TRWARPFYLA FVFCLALGLL CYP4Z1 ---------- ---------- ---MEPSWLQ ELMAHPFLLL ILLCMSLLLF CYP5A1h ---------- ---------- -MMEALGFLK LEVNGPMVTV ALSVALLALL CYP7A1h ---------- ---------- ---------- ---MMTTSLI WGIAIAACCC CYP7B1h ---------- ---------- -MAGEVSAAT GRFSLERLGL PGLALAAALL CYP8A1h ---------- ---------- ---------- ----MAWAAL LGLLVALLL- CYP8B1h ---------- ---------- ---------- ---MVLWGPV LGALLVVIAG CYP11A1h ---------- ---------- -----MLAKG LPPRSVLVKG YQTFLSAPRE CYP11B1h ---------- ---------- ---------- ----MALRAK AEVCMAVPWL CYP11B2h ---------- ---------- ---------- ----MALRAK AEVCVAAPWL CYP17h ---------- ---------- ---------- ---MWELVAL LLLTLAYLFW CYP19h ---------- ---------- ---------- --MVLEMLNP IHYNITSIVP CYP20h ---------- ---------- -------MLD FAIFAVTFLL ALVGAVLYLY CYP21A2h ---------- ---------- ---------- -------MLL LGLLLLLPLL CYP24h ---------- ---------- ---------- ----MSSPIS KSRSLAAFLQ CYP26A1h ---------- ---------- ---MGLPALL ASALCTFVLP LLLFLAAIKL CYP26B1h ---------- --------ML FEGLDLVSAL ATLAACLVSV TLLLAVSQQL CYP26C1h ---------- --------MF PWGLSCLSVL GAAGTALLCA GLLLSLAQHL CYP27A1h ---------- ---------- ---------- ------MAAL GCARLRWALR CYP27B1h ---------- ---------- ---------- -------MTQ TLKYASRVFH CYP27C1h ---------- ---------- ---------- ------MQTS AMALLARILR CYP39A1h ---------- ---------- ---------- -------MEL ISPTVIIILG CYP46h ---------- ---------- ------MSPG LLLLGSAVLL AFGLCCTFVH CYP51h MAAAAGMLLL GLLQAGGSVL GQAMEKVTGG NLLSMLLIAC AFTLSLVYLI Cyp1a1 ---------- ---------- VFCLGFWVVR A--------- ---------- Cyp1a2 ---------- ---------- IFCLVFWMVR A--------- ---------- Cyp1b1 ---------- ---------- VLAAVHLGQW L--------- ---------- Cyp2a4 ---------- ---------- VLVLMSVW-- ---------- ---------- Cyp2a5 ---------- ---------- VLVLMSVW-- ---------- ---------- Cyp2a12 ---------- ---------- VMVLVSVW-- ---------- ---------- Cyp2b9 ---------- ---------- LFLLLVR--- ---------- ---------- Cyp2b10 ---------- ---------- FLLLLAR--- ---------- ---------- Cyp2b13 ---------- ---------- LFLLLVR--- ---------- ---------- Cyp2b19 ---------- ---------- FLIFLVSQ-- ---------- ---------- Cyp2b23 ---------- ---------- FLLLLIR--- ---------- ---------- Cyp2c29 ---------- ---------- CLILLSLW-- ---------- ---------- Cyp2c37 ---------- ---------- CLFLLSLW-- ---------- ---------- Cyp2c38 ---------- ---------- SLILLSLW-- ---------- ---------- Cyp2c39 ---------- ---------- SLILLSLW-- ---------- ---------- Cyp2c40 ---------- ---------- FLLVLSLW-- ---------- ---------- Cyp2c44 ---------- ---------- SLSLLSVW-- ---------- ---------- Cyp2c50 ---------- ---------- CLFLLSLW-- ---------- ---------- Cyp2c54 ---------- ---------- CLFLLSLW-- ---------- ---------- Cyp2c55 ---------- ---------- CLLLLSLW-- ---------- ---------- Cyp2c65 ---------- ---------- CLLLLSLW-- ---------- ---------- Cyp2c66 ---------- ---------- CLLLLSLW-- ---------- ---------- Cyp2c67 ---------- ---------- FLLVLSLW-- ---------- ---------- Cyp2c68 ---------- ---------- FLLLLSLW-- ---------- ---------- Cyp2c69 ---------- ---------- FMLLLSLW-- ---------- ---------- Cyp2c70 ---------- ---------- CFLFLFLW-- ---------- ---------- Cyp2d9 ---------- --------IF TVIFILLVDL T--------- ---------- Cyp2d10 ---------- --------IF TVIFILLVDL M--------- ---------- Cyp2d11 ---------- --------IF TVIFILLVDL M--------- ---------- Cyp2d12 ---------- --------IF TVIFILLVDL M--------- ---------- Cyp2d13 ---------- --------IF TVIFILLVDL M--------- ---------- Cyp2d22 ---------- --------IF TVIFLILVNL M--------- ---------- Cyp2d26 ---------- --------IF TAIFLLLVDL V--------- ---------- Cyp2e1 ---------- ---------- TLLLVSIW-- ---------- ---------- Cyp2f2 ---------- ---------- AVISLSLT-- ---------- ---------- Cyp2g1 ---------- ---------- CLLILIAW-- ---------- ---------- Cyp2j5 LK-------- --------TL VLAVVTFLFL I--------- ---------- Cyp2j6 PR-------- --------TL LVAAVTFLLL A--------- ---------- Cyp2j7 LW-------- --------TL LLTLLVFRLL A--------- ---------- Cyp2j8 LW-------- --------TL LLAALTLLLL V--------- ---------- Cyp2j9 LR-------- --------IL LLSAVTFLFL A--------- ---------- Cyp2j13 LR-------- --------TL LLAAVTFLFL A--------- ---------- Cyp2j12 FK-------- --------TL VLAAVTFMLL A--------- ---------- cyp2j11 LW-------- --------TL LLTLLTLLLL A--------- ---------- Cyp2r1 LA-------- --------GA LLLLLFVLVV R--------- ---------- Cyp2s1 ---------- ---------- LLLLLLS--- L--------- ---------- Cyp2t4 ---------- ---------- ILMLLLWWGG V--------- ---------- Cyp2U1 --------AR LHVRATGGAL LLCLLAVLLG W--------- ---------- Cyp2w1 ---------- ---------- GLLQGCTR-- ---------- ---------- CYP2W1h ---------- ---------- GLLCACAQ-- ---------- ---------- Cyp3a11 Y--------- ---------- RYGTRKHEL- ---------- ---------- Cyp3a13 Y--------- ---------- LYGTHSHGI- ---------- ---------- Cyp3a16 Y--------- ---------- RYGTYTHGL- ---------- ---------- Cyp3a25 Y--------- ---------- IYGTYSHGL- ---------- ---------- Cyp3a57 Y--------- ---------- IYGTYSHGL- ---------- ---------- Cyp3a41 Y--------- ---------- RYGTRTHGL- ---------- ---------- Cyp3a44 Y--------- ---------- RYGTRTHGL- ---------- ---------- Cyp4a10 K--------- ---------- AVQFYLHRQ- ---------- ---------- Cyp4a12 K--------- ---------- TAQLYLHRQ- ---------- ---------- Cyp4a14 K--------- ---------- AVQFYLRRQ- ---------- ---------- Cyp4a30 K--------- ---------- SAQYYLHRQ- ---------- ---------- Cyp4a29 K--------- ---------- AAQHYLRRQ- ---------- ---------- Cyp4b1 K--------- ---------- LLSLLFRRQ- ---------- ---------- Cyp4f13 R--------- ---------- ILAWIYAFY- ---------- ---------- Cyp4f14 R--------- ---------- ILIQIYAAY- ---------- ---------- Cyp4f15 R--------- ---------- VLTQTYIFY- ---------- ---------- Cyp4f16 R--------- ---------- ILAWTYSFY- ---------- ---------- Cyp4f17 R--------- ---------- ILTWICAFY- ---------- ---------- Cyp4f18 Y--------- ---------- ILTQIYGVF- ---------- ---------- Cyp4f37 R--------- ---------- ILAWTYSFC- ---------- ---------- Cyp4f39 R--------- ---------- AFKLFSDFR- ---------- ---------- Cyp4f40 R--------- ---------- FLTQLYTLY- ---------- ---------- Cyp4v3 ---------- ---------- IFPMLVSYA- ---------- ---------- Cyp4x1 Q--------- ---------- AMKLYLRRQ- ---------- ---------- Cyp5a1 K--------- ---------- WYSMSAFSR- ---------- ---------- Cyp7a1 ---------- ---------- IWFIIGIRR- ---------- ---------- Cyp7b1 ---------- ---------- LSALFLLTRR ---------- ---------- Cyp8a1 ---------- ---------- LLLLLSRRR- ---------- ---------- Cyp8b1 ---------- ---------- CLCLSLLLR- ---------- ---------- Cyp11a1 GP-------- --------VL STGKGAGTST S--------- ---------- Cyp11b1 CLHR------ --------TR ALGTTATLAP K--------- ---------- Cyp11b2 CLHR------ --------TR ALGTTATLAP K--------- ---------- Cyp17 P--------- ---------- ---------- ---------- ---------- Cyp19 ---------- -------ETV TVSAMPLLLI MG-------- ---------- Cyp20 P--------- ---------- ASRQASGIP- ---------- ---------- Cyp21 A--------- ---------- ---------- ---------- ---------- Cyp24 R--------- --------LR DLGQPPRSVT SKAHVKRAPK E--------- Cyp26a1 ---------- ---------- WDLYCVSSRD ---------- ---------- Cyp26b1 ---------- ---------- WQLRWAATRD ---------- ---------- Cyp26c1 ---------- ---------- WTLRWTLSRD ---------- ---------- Cyp27a1 DPRVVG---- -RGLCPQGAR AKATIPAALQ AQESTEGPGT G--------- Cyp27b1 R--------- --------IH LPLQLDASLG S--------- ---------- Cyp39 ---------- ---------- SCVLFLFSR- ---------- ---------- Cyp46 R--------- ---------- ARSRYEHIP- ---------- ---------- Cyp51 ---------- ---------- RLAVGHMVQL ---------- ---------- CYP1A1h ---------- ---------- IFCLVFWVIR A--------- ---------- CYP1A2h ---------- ---------- IFCLVFWVLK G--------- ---------- CYP1B1h ---------- ---------- VLATVHVGQR L--------- ---------- CYP2A6 ---------- ---------- VMVLMSVW-- ---------- ---------- CYP2A7 ---------- ---------- VMVLMSVW-- ---------- ---------- CYP2A13 ---------- ---------- VMVLMSVW-- ---------- ---------- CYP2B6 ---------- ---------- LLLLLVQ--- ---------- ---------- CYP2C8 ---------- ---------- FMLLFSLW-- ---------- ---------- CYP2C9 ---------- ---------- CLLLLSLW-- ---------- ---------- CYP2C18 ---------- ---------- CLFLLSLW-- ---------- ---------- CYP2C19 ---------- ---------- CLLLLSIW-- ---------- ---------- CYP2D6 ---------- --------VI VAIFLLLVDL M--------- ---------- CYP2E1h ---------- ---------- FLLLVSMW-- ---------- ---------- CYP2F1 ---------- ---------- ALVCLLLT-- ---------- ---------- CYP2G2P ---------- ---------- CLLILIAW-- ---------- ---------- CYP2J2 PR-------- --------TL LLGTVAFLLA A--------- ---------- CYP2R1h LG-------- --------GA LFLLLFALGV R--------- ---------- CYP2S1h ---------- ---------- LLLLLT---- L--------- ---------- CYP2T2P ---------- ---------- ---------- ---------- ---------- CYP2U1h ARLLRAPLGL LRLDPSGGAL LLCGLVALLG W--------- ---------- CYP3A4 Y--------- ---------- LYGTHSHGL- ---------- ---------- CYP3A5 Y--------- ---------- LYGTRTHGL- ---------- ---------- CYP3A7 Y--------- ---------- LYGTRTHGL- ---------- ---------- CYP3A43 Y--------- ---------- IYGTHSHKL- ---------- ---------- CYP4A11 K--------- ---------- AVQLYLHRQ- ---------- ---------- CYP4A22 K--------- ---------- AAQLYLHRQ- ---------- ---------- CYP4B1h K--------- ---------- LIHLLLRRR- ---------- ---------- CYP4F2 H--------- ---------- VLAWTYAFY- ---------- ---------- CYP4F3 R--------- ---------- ILAWTYTFY- ---------- ---------- CYP4F8 R--------- ---------- ILAWTYAFY- ---------- ---------- CYP4F11 R--------- ---------- VLAWTYTFY- ---------- ---------- CYP4F12 R--------- ---------- ILAWTYAFY- ---------- ---------- CYP4F22 R--------- ---------- FLRLCRSFY- ---------- ---------- CYP4F23P R--------- ---------- VLAWTYAFY- ---------- ---------- CYP4V2 ---------- ---------- LLQRVASYA- ---------- ---------- CYP4X1h Q--------- ---------- AIKLYLRRQ- ---------- ---------- CYP4Z1 Q--------- ---------- VIRLYQRRR- ---------- ---------- CYP5A1h K--------- ---------- WYSTSAFSR- ---------- ---------- CYP7A1h ---------- ---------- LWLILGIRR- ---------- ---------- CYP7B1h ---------- ---------- LLALCLLVRR ---------- ---------- CYP8A1h ---------- ---------- LLLLS-RRR- ---------- ---------- CYP8B1h ---------- ---------- YLCLPGMLR- ---------- ---------- CYP11A1h GLGRL----- --------RV PTGEGAGIST R--------- ---------- CYP11B1h SLQR------ --------AQ ALGTRAARVP R--------- ---------- CYP11B2h SLQR------ --------AR ALGTRAARAP R--------- ---------- CYP17h P--------- ---------- ---------- ---------- ---------- CYP19h ---------- -------EAM PAATMPVLLL TG-------- ---------- CYP20h P--------- ---------- ASRQAAGIP- ---------- ---------- CYP21A2h A--------- ---------- ---------- ---------- ---------- CYP24h Q--------- --------LR SPRQPPRLVT STAYTSPQPR E--------- CYP26A1h ---------- ---------- WDLYCVSGRD ---------- ---------- CYP26B1h ---------- ---------- WQLRWAATRD ---------- ---------- CYP26C1h ---------- ---------- WTLRWMLSRD ---------- ---------- CYP27A1h G--AG----- -RGLCPHGAR AKAAIPAALP SDKATGAPGA G--------- CYP27B1h R--------- --------VR WAPELGASLG Y--------- ---------- CYP27C1h AG-------- --------LR PAPERGGLLG GGAPRRPQPA GARLPAGARA CYP39A1h ---------- ---------- CLALFLLLQ- ---------- ---------- CYP46h R--------- ---------- ARSRYEHIP- ---------- ---------- CYP51h ---------- ---------- RLAAGHLVQL ---------- ---------- Cyp1a1 ---------- ----TRTWVP KGLKTPPGPW GLPFIGHMLT VGKNPH---- Cyp1a2 ---------- ----SRTQVP KGLKNPPGPW GLPFIGHMLT VGKNPH---- Cyp1b1 ---------- ----LRQWQR KPWSSPPGPF PWPLIGNAAA VGQASH---- Cyp2a4 ---------- ------KQRK LSGKLPPGPT PLPFVGNFLQ LNTEQMY--- Cyp2a5 ---------- ------KQRK LSGKLPPGPT PLPFIGNFLQ LNTEQMY--- Cyp2a12 ---------- ------QQKI R-GKLPPGPI PLPFIGNYLQ LNRKDVY--- Cyp2b9 ---------- ------GHAK IHGHLPPGPH PLPLLGNLLQ MDRGGLL--- Cyp2b10 ---------- ------GHPK SRGNFPPGPR PLPLLGNLLQ MDRGGLL--- Cyp2b13 ---------- ------GHAK IHGHLPPGPR PLPLLGNLLQ MDRGGLL--- Cyp2b19 ---------- ------SQPK THGHFPPGPR PLPFLGNLLQ MDRRGLL--- Cyp2b23 ---------- ------GQPK AYSRLPPGPR PLPFLGNLLQ MDRGGLL--- Cyp2c29 ---------- ------RQSS GRGKLPPGPT PLPIIGNFLQ IDVKNIS--- Cyp2c37 ---------- ------RQSS ERGKLPPGPT PLPIIGNILQ IDVKDIC--- Cyp2c38 ---------- ------RQRS RRGRLPPGPT PFPIIGNFLQ IDVKNFN--- Cyp2c39 ---------- ------RQSC GRGSLPPGPT PFPIIGNFLQ IDMKNFS--- Cyp2c40 ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- Cyp2c44 ---------- ------TKMR TGGRLPPGPT PLPIIGNILQ LDLKDIP--- Cyp2c50 ---------- ------RQSS ERGKLPPGPT PLPIIGNILQ INVKDIC--- Cyp2c54 ---------- ------RQSY ERGKLPPGPT PLPIIGNILQ IDVKDIC--- Cyp2c55 ---------- ------RQNS GRGKLPPGPT PFPIIGNILQ IDIKNIS--- Cyp2c65 ---------- ------RQNS QRRNLPPGPT PLPIIGNILQ LDLKDIS--- Cyp2c66 ---------- ------KQNS QRRNLPPGPT PLPIIGNILQ LDLKDIS--- Cyp2c67 ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- Cyp2c68 ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- Cyp2c69 ---------- ------RQRS ARRNLPPGPT PLPIIGNYHL IDMKDIG--- Cyp2c70 ---------- ------NQHR GRGKLPPGPT PLPIVGNILQ VYVKNIS--- Cyp2d9 ---------- ----HQR-QR WTSRYPPGPV PWPVLGNLLQ VDLGNMP--- Cyp2d10 ---------- ----HRH-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- Cyp2d11 ---------- ----HRH-QH WTSRCPPGPV PWPVLGNLLQ VDLDNMP--- Cyp2d12 ---------- ----YRR-QS WTSCYPPGPV PWPVLGNLLQ VDLNNMP--- Cyp2d13 ---------- ----HRR-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- Cyp2d22 ---------- ----HWR-QR WTAHYPPGPM PWPVLGNLLH MDFQNMP--- Cyp2d26 ---------- ----HRR-QR WTACYPPGPV PFPGLGNLLQ VDFENIP--- Cyp2e1 ---------- ------KQIY RSWNLPPGPF PIPFFGNIFQ LDLKDIP--- Cyp2f2 ---------- ------FSSR GKGQLPPGPK PLPILGNLLQ LRSQDLL--- Cyp2g1 ---------- ------KRTS KGGKLPPGPT PIPFLGNFLQ VRTDATF--- Cyp2j5 ---------- ----NILRSR HPKNYPPGPW RLPFVGNFFQ IDTKQT---- Cyp2j6 ---------- ----DYFKNR RPKNYPPGPW GLPFVGNIFQ LDFGQP---- Cyp2j7 ---------- ----DYLKNR RPKNYPPGPW RLPFVGNLFQ FDLDVSQ--- Cyp2j8 ---------- ----DYIKNR HPKNYPPGPW RLPFVGNLFQ FDLDVSH--- Cyp2j9 ---------- ----DFLKNR RPKNYPPWPM RLPFVGCLFH LDPKQP---- Cyp2j13 ---------- ----DYLKSR RPKNYPPRPP RLPFVGNSFQ MDLTQS---- Cyp2j12 ---------- ----HYLKTQ RPKNYPPGPW RLPFVGNLFQ LDLEQP---- cyp2j11 ---------- ----DYLKNR RPKNYPPGPR RLPFVGNLFQ FDLDVSR--- Cyp2r1 ---------- ----QLLRQR RPAGFPPGPP RLPFVGNICS LALSADL--- Cyp2s1 ---------- ----TLFRTP ARGYLPPGPT PLPLLGNLLQ LRPGALY--- Cyp2t4 ---------- ----VRRQAQ MQKDLPPGPA PLPLLGNLLQ LQSGDLD--- Cyp2U1 ---------- ----VWLRRQ RACGIPPGPK PRPLVGNFGH LLVPRFLRPQ Cyp2w1 ---------- -------SPS LAPRWPPGPR PLPFLGNLHL LGVTQQD--- CYP2W1h ---------- -------DPS PAARWPPGPR PLPLVGNLHL LRLSQQD--- Cyp3a11 ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYKG------ Cyp3a13 ---------- ---------- FKKLGIPGPK PLPFLGTILA YQKG------ Cyp3a16 ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYKG------ Cyp3a25 ---------- ---------- FKKLGIPGPK PLPLLGTIFN YYDG------ Cyp3a57 ---------- ---------- FKKLGIPGPK PLPLFGNIIN YLDG------ Cyp3a41 ---------- ---------- FKKQGIPGPT PLPFLGTVLN YYKG------ Cyp3a44 ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYTG------ Cyp4a10 ---------- ------WLLK AFQQFPSPPF -HWFFGHEQF KG---DH--- Cyp4a12 ---------- ------WLLS STQQFPSPPS -HWLFGHKIL K----DQ--- Cyp4a14 ---------- ------WLLK TLQHFPCMPS -HWLWGHHLK D-----K--- Cyp4a30 ---------- ------WLIK SLQQFPPAPP -PQWLFGNXX FPK--DQ--- Cyp4a29 ---------- ------WLLR ALYQFPSPPS -HWLFGHQFK VD----E--- Cyp4b1 ---------- ------KLAR ALDSFPGPPK -HWLFGHALE IQK--TG--- Cyp4f13 ---------- ------DNCS RLRCFPQPPK PSWFWGHLAL MKNN-EE--- Cyp4f14 ---------- ------RNYR HLHGFPQPPK RNWLMGHVGM VTPT-EQ--- Cyp4f15 ---------- ------RTYH HLCDFPQPPK WNWFLGHLGM ITPT-EH--- Cyp4f16 ---------- ------ENCS RLSCFPQPPK KNWFSGHLGM IQSN-EE--- Cyp4f17 ---------- ------DNYC RLRCFPEPPS RHWFWGHMSM VKNN-EE--- Cyp4f18 ---------- ------ENSL RLRCFPQPPK RNWILGHLGL IQSS-EE--- Cyp4f37 ---------- ------ENCS RLRCFPQPPK RNWFLGHLGM IEHN-EE--- Cyp4f39 ---------- ------ITCR KLSCFPEPPG RHWLLGHMSM VSPN-EK--- Cyp4f40 ---------- ------AKCQ RLCGFPQPPK KNWFWGHLGM VSPT-EE--- Cyp4v3 ---------- ------RKWQ QMRSIPSVAR AYPLVGHALY MKPNNAE--- Cyp4x1 ---------- ------RLLR DLSPFPGPPA -HWLLGHQKF LQ---ED--- Cyp5a1 ---------- ------LEKL GIRHPKPSP- ---FVGNLMF FRQG------ Cyp7a1 ---------- ---------R KVGEPPLDNG LIPYLGCALK FGSNPLE--- Cyp7b1 ---------- --------TR RPREPPLIKG WLPYLGMALK FFKDPLT--- Cyp8a1 ---------- --------AR RPGEPPLDLG SIPWLGHALE FGRDAAS--- Cyp8b1 ---------- --------HR RPWEPPLDKG FVPWLGHSMA FRKNMFE--- Cyp11a1 ---------- ------SPRS FNEIPSPGDN GWLNLYHFWR ESGTQKIH-- Cyp11b1 ---------- ------TLQP FEAIPQYSRN KWLKMIQILR EQGQENLH-- Cyp11b2 ---------- ------TLQP FEAIPQYSRN KWLKMIQILR EQGQENLH-- Cyp17 ---------- ------KSKT PNAKFPRSLP FLPLVGSLPF LPRRGHMH-- Cyp19 ---------- --LLLLIWNC ESSSSIPGPG YCLGIGPLIS HGRFLWMG-- Cyp20 ---------- ------GLTP TEEKDGNLP- -------DIV NSGSLHE--- Cyp21 ---------- ------GTRW LWGQWKLRKL HLPPLAPGFL HFLQPNLP-- Cyp24 -----VPLCP LMTDGETRNV TSLPGPTNWP LLGSLLEIFW KGGLKKQH-- Cyp26a1 ---------- --------RS CALPLPPGTM GFPFFGETLQ MVLQRRK--- Cyp26b1 ---------- --------KS CKLPIPKGSM GFPLIGETGH WLLQGSG--- Cyp26c1 ---------- --------WA STLPLPKGSM GWPFFGETLH WLVQGSR--- Cyp27a1 ---------- ---Q-DRPRL RSPAELPGTG TLQFLFQLFL QGYVLHLP-- Cyp27b1 ---------- ---RGSESVL RSLSDIPGPS TLSFLAELFC KGGLSRLH-- Cyp39 ---------- --------LK NLLGPPCIQG WIPWIGAGLE FGKAPLE--- Cyp46 ---------- ------GPPR PSFLLGHLPY ---FWKKDED CGRVLQD--- Cyp51 ---------- --------PA GAKSPPHIYS PIPFLGHAIA FGKSPIE--- CYP1A1h ---------- ----SRPQVP KGLKNPPGPW GWPLIGHMLT LGKNPH---- CYP1A2h ---------- ----LRPRVP KGLKSPPEPW GWPLLGHVLT LGKNPH---- CYP1B1h ---------- ----LRQRRR QLRSAPPGPF AWPLIGNAAA VGQAAH---- CYP2A6 ---------- ------QQRK SKGKLPPGPT PLPFIGNYLQ LNTEQMY--- CYP2A7 ---------- ------QQRK SRGKLPPGPT PLPFIGNYLQ LNTEHIC--- CYP2A13 ---------- ------RQRK SRGKLPPGPT PLPFIGNYLQ LNTEQMY--- CYP2B6 ---------- ------RHPN THDRLPPGPR PLPLLGNLLQ MDRRGLL--- CYP2C8 ---------- ------RQSC RRRKLPPGPT PLPIIGNMLQ IDVKDIC--- CYP2C9 ---------- ------RQSS GRGKLPPGPT PLPVIGNILQ IGIKDIS--- CYP2C18 ---------- ------RQSS GRGRLPSGPT PLPIIGNILQ LDVKDMS--- CYP2C19 ---------- ------RQSS GRGKLPPGPT PLPVIGNILQ IDIKDVS--- CYP2D6 ---------- ----HRR-QR WAARYPPGPL PLPGLGNLLH VDFQNTP--- CYP2E1h ---------- ------RQVH SSWNLPPGPF PLPIIGNLFQ LELKNIP--- CYP2F1 ---------- ------LSSR DKGKLPPGPR PLSILGNLLL LCSQDML--- CYP2G2P ---------- ------KMN- KAGKLPPGPT PIPFLGNLLQ VRTDATF--- CYP2J2 ---------- ----DFLKRR RPKNYPPGPW RLPFLGNFFL VDFEQS---- CYP2R1h ---------- ----QLLKQR RPMGFPPGPP GLPFIGNIYS LAASSEL--- CYP2S1h ---------- ----ALSGTR ARGHLPPGPT PLPLLGNLLQ LRPGALY--- CYP2T2P ---------- -------RAQ MRGSLPPRPR PLPLLG-NLQ LQSGGLD--- CYP2U1h ---------- ----SWLRRR RARGIPPGPT PWPLVGNFGH VLLPPFLRRR CYP3A4 ---------- ------FKKL GIPGPTPLP- ---FLGNILS YHKG------ CYP3A5 ---------- ------FKRL GIPGPTPLP- ---LLGNVLS YRQG------ CYP3A7 ---------- ------FKKL GIPGPTPLP- ---FLGNALS FRKG------ CYP3A43 ---------- ------FKKL GIPGPTPLP- ---FLGTILF YLRG------ CYP4A11 ---------- ------WLLK ALQQFPCPPS -HWLFGHIQE LQQ--DQ--- CYP4A22 ---------- ------WLLK ALQQFPCPPS -HWLFGHIQE FQH--DQ--- CYP4B1h ---------- ------TLAK AMDKFPGPPT -HWLFGHALE IQE--TG--- CYP4F2 ---------- ------DNCR RLRCFPQPPR RNWFWGHQGM IHSS-EE--- CYP4F3 ---------- ------DNCC RLRCFPQPPK RNWFLGHLGL IHSS-EE--- CYP4F8 ---------- ------HNGR RLRCFPQPRK QNWFLGHLGL VTPT-EE--- CYP4F11 ---------- ------DNCR RLQCFPQPPK QNWFWGHQGL VTPT-EE--- CYP4F12 ---------- ------NNCR RLQCFPQPPK RNWFWGHLGL ITPT-EE--- CYP4F22 ---------- ------ITCR RLRCFPQPPR RNWLLGHLGM VSPN-EA--- CYP4F23P ---------- ------DNCH RLQCFQQPPK RNCFG-HLSL VSGN-EE--- CYP4V2 ---------- ------RKWQ QMRPIPTVAR AYPLVGHALL MKPDGRE--- CYP4X1h ---------- ------RLLR DLRPFPAPPT -HWFLGHQKF IQ---DD--- CYP4Z1 ---------- ------WMIR ALHLFPAPPA -HWFYGHKEF YP---VK--- CYP5A1h ---------- ------LEKL GLRHPKPSP- ---FIGNLTF FRQG------ CYP7A1h ---------- ---------R QTGEPPLENG LIPYLGCALQ FGANPLE--- CYP7B1h ---------- --------TR RPGEPPLIKG WLPYLGVVLN LRKDPLR--- CYP8A1h ---------- --------TR RPGEPPLDLG SIPWLGYALD FGKDAAS--- CYP8B1h ---------- --------QR RPWEPPLDKG TVPWLGHAMA FRKNMFE--- CYP11A1h ---------- ------SPRP FNEIPSPGDN GWLNLYHFWR ETGTHKVH-- CYP11B1h ---------- ------TVLP FEAMPRRPGN RWLRLLQIWR EQGYEDLH-- CYP11B2h ---------- ------TVLP FEAMPQHPGN RWLRLLQIWR EQGYEHLH-- CYP17h ---------- ------KRRC PGAKYPKSLL SLPLVGSLPF LPRHGHMH-- CYP19h ---------- --LFLLVWNY EGTSSIPGPG YCMGIGPLIS HGRFLWMG-- CYP20h ---------- ------GITP TEEKDGNLP- -------DIV NSGSLHE--- CYP21A2h ---------- ------GARL LWNWWKLRSL HLPPLAPGFL HLLQPDLP-- CYP24h -----VPVCP LTAGGETQNA AALPGPTSWP LLASLLQILW KGGLKKQH-- CYP26A1h ---------- --------RS CALPLPPGTM GFPFFGETLQ MVLQRRK--- CYP26B1h ---------- --------KS CKLPIPKGSM GFPLIGETGH WLLQGSG--- CYP26C1h ---------- --------RA STLPLPKGSM GWPFFGETLH WLVQGSR--- CYP27A1h ---------- ---PGVRRRQ RSLEEIPRLG QLRFFFQLFV QGYALQLH-- CYP27B1h ---------- ---REYHSAR RSLADIPGPS TPSFLAELFC KGGLSRLH-- CYP27C1h EDKGAGRPGS PPGGGRAEGP RSLAAMPGPR TLANLAEFFC RDGFSRIH-- CYP39A1h ---------- --------RK NLRRPPCIKG WIPWIGVGFE FGKAPLE--- CYP46h ---------- ------GPPR PSFLLGHLPC ---FWKKDEV GGRVLQD--- CYP51h ---------- --------PA GVKSPPYIFS PIPFLGHAIA FGKSPIE--- Cyp1a1 ---------- ---------- LSLTRLSQQY GDVLQIRIGS T---PVVVLS Cyp1a2 ---------- ---------- LSLTRLSQQY GDVLQIRIGS T---PVVVLS Cyp1b1 ---------- ---------- LYFARLARRY GDVFQIRLGS C---PVVVLN Cyp2a4 ---------- ---------- NSLMKISQRY GPVFTIYLGS R---RIVVLC Cyp2a5 ---------- ---------- NSLMKISQRY GPVFTIYLGP R---RIVVLC Cyp2a12 ---------- ---------- SSITQLQEHY GPVFTIHLGP R---RVVVLY Cyp2b9 ---------- ---------- KCFIQLQEKH GDVFTVHLGP R---PVVVLC Cyp2b10 ---------- ---------- KSFIQLREKY GDVFTVHLGP R---PVVMLC Cyp2b13 ---------- ---------- KCFIHLQEKH GDVFTVHLGP R---PVVVLC Cyp2b19 ---------- ---------- SSFIQLQEKY GDVFTVHLGP R---PVVMLC Cyp2b23 ---------- ---------- KSFIKLRDKH GDVFTVHLGP R---PVVMLY Cyp2c29 ---------- ---------- QSFTNFSKAY GPVFTLYLGS K---PTVILH Cyp2c37 ---------- ---------- QSFTNLSKVY GPVYTLYLGR K---PTVVLH Cyp2c38 ---------- ---------- QSLTNFSKAY GPVFTLYLGS R---PIVVLH Cyp2c39 ---------- ---------- QSLTNFSKAY GPVFTLYLGS R---PTVVLH Cyp2c40 ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH Cyp2c44 ---------- ---------- ASLSKLAKEY GPVYTLYFGS W---PTVVLH Cyp2c50 ---------- ---------- QSFTNLSKVY GPVYTLYLGN K---PTVVLH Cyp2c54 ---------- ---------- QSFTNLSRVY GPVYTLYLGR K---PTVVLH Cyp2c55 ---------- ---------- KSFNYFSKVY GPVFTLYFGS K---PTVVVH Cyp2c65 ---------- ---------- KSLRNFSKVY GPVFTLYLGR N---PAVVLH Cyp2c66 ---------- ---------- KSLRNFSKVY GPVFTLYLGK K---PAVVLH Cyp2c67 ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH Cyp2c68 ---------- ---------- QCLTNFSKIY GPVFTLYFGS Q---PIVILH Cyp2c69 ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH Cyp2c70 ---------- ---------- KSMGMLAKKY GPVFTVYLGM K---PTVVLH Cyp2d9 ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN Cyp2d10 ---------- ---------- YSLYKLQNRY GDVFSLQMGW K---PMVVIN Cyp2d11 ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN Cyp2d12 ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN Cyp2d13 ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PVVVIS Cyp2d22 ---------- ---------- AGFQKLRGRY GDLFSLQLAS E---SVVVLN Cyp2d26 ---------- ---------- YSFYKLQNRY GNVFSLQMAW K---PVVVVN Cyp2e1 ---------- ---------- KSLTKLAKRF GPVFTLHLGQ R---RIVVLH Cyp2f2 ---------- ---------- TSLTKLSKEY GSVFTVYLGS R---PVIVLS Cyp2g1 ---------- ---------- QSFQKLQKKY GSVFTVYFGP R---PVVVLC Cyp2j5 ---------- ---------H LVLQQFVKKY GNVFSLELGQ S---PVVVVS Cyp2j6 ---------- ---------H LSIQPLVKKY GNIFSLNLGD I---TSVVIT Cyp2j7 ---------- --------LH LRIQLFVKKY GNLISIDFGN I---SSVVIT Cyp2j8 ---------- --------LH LGIQPFVKKY GNLISLDFGT I---PSVIIS Cyp2j9 ---------- ---------H LSLQQFVKKY GNVLSLDFAN I---PSVVIT Cyp2j13 ---------- ---------H LAVQKFVKKY GNVISLDFGI K---SAVIIS Cyp2j12 ---------- ---------H VVIQQFVKKY GNLTSLDFGN I---PSVIIT cyp2j11 ---------- --------LH LGIQPFVKKY GNVISVNFGY I---SSVIIS Cyp2r1 ---------- --------PH VYMRKQSRVY GEIFSLDLGG I---STVVLN Cyp2s1 ---------- ---------- SGLLRLSKKY GPVFTVYLGP W--RRVVVLV Cyp2t4 ---------- ---------- RVLMELSSHW GPVFTVWLGP L---PAVVLC Cyp2U1 FWLGS----- GSQTDTVGQH VYLARMARVY GNIFSFFIGH R---LVVVLS Cyp2w1 ---------- ---------- RALMELSERY GPMFTIHLGS Q---KTVVLS CYP2W1h ---------- ---------- RSLMELSERY GPVFTVHLGR Q---KTVVLT Cyp3a11 ---------- --------LW KFDMECYKKY GKTWGLFDGQ --T-PLLAVT Cyp3a13 ---------- --------FW ECDIQCHKKY GKMWGLYDGR --Q-PVLAIT Cyp3a16 ---------- --------LW KFDMECYEKY GKTWGLFDGQ --I-PLFVIT Cyp3a25 ---------- --------MW KFDEDCYKKY GKIWGFYEGP --Q-PILAIM Cyp3a57 ---------- --------MW KFDDDCYKKY GKIWGFYEGP --Q-PILAIM Cyp3a41 ---------- --------LW KFDMECYEKY GKTWGLFDGQ --M-PLFVIT Cyp3a44 ---------- --------IW KFDMECYEKY GKTWGLFDGQ --T-PLLVIT Cyp4a10 ---------- --------EL QEIVSCIENF PSAFPRWFWG -SK-AYLTVY Cyp4a12 ---------- --------DL QDILTRIKNF PSACPQWLWG -SK-VRIQVY Cyp4a14 ---------- --------EL QQILIWVEKF PSACLQCLSG -SN-IRVLLY Cyp4a30 ---------- --------DL QQILLCVEKF PSTYVRWLWG -NH-ARVVIY Cyp4a29 ---------- --------EL RWILRYLEKF PGAFLHWIWG -SH-VFIKVC Cyp4b1 ---------- --------GL DKVVTWTEQF PYAHPLWLGQ -FI-VFLNIY Cyp4f13 ---------- --------SM QFITHLGHDF HDVHLSWVGP -VY-PILRLV Cyp4f14 ---------- --------GL KELTRLVGTY PQGFLMWIGP -MV-PVITLC Cyp4f15 ---------- --------GL KEVTNLVATY PQGFMTWLGP -II-PIITLC Cyp4f16 ---------- --------GM QLVTEMGQAF QDVHLFWLGP -VI-PVLRIV Cyp4f17 ---------- --------GL QLLTERSHQF HDVHLCWIGP -FY-PILRLI Cyp4f18 ---------- --------GL LYIQSLVRTF RDACCWWVGP -LH-PVIRIF Cyp4f37 ---------- --------GM QLMTEAGQTY RDVHLCWLGP -VI-PVLRIV Cyp4f39 ---------- --------GL QNEKKVLDTM HHIILAWVGP -FL-PLLVLV Cyp4f40 ---------- --------GM KQVTELVTTY PQGFMTWLGP -IV-PLITLC Cyp4v3 ---------- --------FF QQLIYYTEEF RHLPIIKLWI GPV-PLVALY Cyp4x1 ---------- --------NM ETLDEIVKKH PCAFPCWVGP -FQ-AFFYIY Cyp5a1 ---------- --------FW ESQLELRERY GPLCGYYLGR --R-MHVVIS Cyp7a1 ---------- ---------- -FLRAKQRKH GHVFTCKLMG K---YVHFIT Cyp7b1 ---------- ---------- -FLKTLQRQH GDTFTVFLVG K---YITFVL Cyp8a1 ---------- ---------- -FLTRMKEKH GDIFTVLVGG R---YVTVLL Cyp8b1 ---------- ---------- -FLKGMRAKH GDVFTVQLGG Q---YFTFVM Cyp11a1 ---------- ---------- YHQMQSFQKY GPIYREKLGT L---ESVYIV Cyp11b1 ---------- ---------- LEMHQVFREL GPIFRHSVGK T---QIVFVT Cyp11b2 ---------- ---------- LEMHQVFREL GPIFRHSVGK T---QIVSVM Cyp17 ---------- ---------- ANFFKLQEKY GPIYSLRLGT T---TAVIVG Cyp19 ---------- --------IG SACNYYNKMY GEFMRVWISG E--ETLIISK Cyp20 ---------- --------FL VNLHERYGPV V---SFWFGR RLV-VSLGTT Cyp21 ---------- ---------- IYLLGLTQKL GPIYRIRLGM Q---DVVVLN Cyp24 ---------- ---------- DTLAEYHKKY GQIFRMKLGS F---DSVHLG Cyp26a1 ---------- ---------- -FLQMKRRKY GFIYKTHLFG R---PTVRVM Cyp26b1 ---------- ---------- -FQSSRREKY GNVFKTHLLG R---PLIRVT Cyp26c1 ---------- ---------- -FHSSRRERY GTVFKTHLLG R---PVIRVS Cyp27a1 ---------- ---------- DLQVLNKTKY GPMWTTSFGT Y---TNVNLA Cyp27b1 ---------- ---------- ELQVHGAARY GPIWSGSFGT L---RTVYVA Cyp39 ---------- ---------- -FIEKARIKY GPVFTIFAMG N---RMTFVS Cyp46 ---------- --------VF LDWAKKYGPV VRVNVFYKTS VIV-TSPESV Cyp51 ---------- ---------- -FLENAYEKY GPVFSLTMVG K---TFTYLL CYP1A1h ---------- ---------- LALSRMSQQY GDVLQIRIGS T---PVVVLS CYP1A2h ---------- ---------- LALSRMSQRY GDVLQIRIGS T---PVLVLS CYP1B1h ---------- ---------- LSFARLARRY GDVFQIRLGS C---PIVVLN CYP2A6 ---------- ---------- NSLMKISERY GPVFTIHLGP R---RVVVLC CYP2A7 ---------- ---------- DSIMKFSECY GPVFTIHLGP R---RVVVLC CYP2A13 ---------- ---------- NSLMKISERY GPVFTIHLGP R---RVVVLC CYP2B6 ---------- ---------- KSFLRFREKY GDVFTVHLGP R---PVVMLC CYP2C8 ---------- ---------- KSFTNFSKVY GPVFTVYFGM N---PIVVFH CYP2C9 ---------- ---------- KSLTNLSKVY GPVFTLYFGL K---PIVVLH CYP2C18 ---------- ---------- KSLTNFSKVY GPVFTVYFGL K---PIVVLH CYP2C19 ---------- ---------- KSLTNLSKIY GPVFTLYFGL E---RMVVLH CYP2D6 ---------- ---------- YCFDQLRRRF GDVFSLQLAW T---PVVVLN CYP2E1h ---------- ---------- KSFTRLAQRF GPVFTLYVGS Q---RMVVMH CYP2F1 ---------- ---------- TSLTKLSKEY GSMYTVHLGP R---RVVVLS CYP2G2P ---------- ---------- QSFMKLREKY SPVFTVYMGP R---PVVVLC CYP2J2 ---------- ---------H LEVQLFVKKY GNLFSLELGD I---SAVLIT CYP2R1h ---------- --------PH VYMRKQSQVY GEIFSLDLGG I---STVVLN CYP2S1h ---------- ---------- SGLMRLSKKY GPVFTIYLGP W--RPVVVLV CYP2T2P ---------- ---------- RALHSLSGRW GRVFTVRLGP R---PAVGLC CYP2U1h SWLSSRTRAA GIDPSVIGPQ VLLAHLARVY GSIFSFFIGH Y---LVVVLS CYP3A4 ---------- --------FC MFDMECHKKY GKVCGFYDGQ --Q-PVLAIT CYP3A5 ---------- --------LW KFDTECYKKY GKMWGTYEGQ --L-PVLAIT CYP3A7 ---------- --------YW TFDMECYKKY RKVWGIYDCQ --Q-PMLAIT CYP3A43 ---------- --------LW NFDRECNEKY GEMWGLYEGQ --Q-PMLVIM CYP4A11 ---------- --------EL QRIQKWVETF PSACPHWLWG -GK-VRVQLY CYP4A22 ---------- --------EL QRIQERVKTF PSACPYWIWG -GK-VRVQLY CYP4B1h ---------- --------SL DKVVSWAHQF PYAHPLWFGQ -FI-GFLNIY CYP4F2 ---------- --------GL LYTQSLACTF GDMGCWWVGP -WQ-AVIHIF CYP4F3 ---------- --------GL LYTQSLACTF GDMCCWWVGP -WH-AIVRIF CYP4F8 ---------- --------GL RVLTQLVATY PQGFVRWLGP -IT-PIINLC CYP4F11 ---------- --------GM KTLTQLVTTY PQGFKLWLGP -TF-PLLILC CYP4F12 ---------- --------GL KDSTQMSATY SQGFTVWLGP -II-PFIVLC CYP4F22 ---------- --------GL QDEKKVLDNM HHVLLVWMGP -VL-PLLVLV CYP4F23P ---------- --------DM RLMEDLGHYF RDVQLWWLGS -FY-PVLHLV CYP4V2 ---------- --------FF QQIIEYTEEY RHMPLLKLWV GPV-PMVALY CYP4X1h ---------- --------NM EKLEEIIEKY PRAFPFWIGP -FQ-AFFCIY CYP4Z1 ---------- --------EF EVYHKLMEKY PCAVPLWVGP -FT-MFFSVH CYP5A1h ---------- --------FW ESQMELRKLY GPLCGYYLGR --R-MFIVIS CYP7A1h ---------- ---------- -FLRANQRKH GHVFTCKLMG K---YVHFIT CYP7B1h ---------- ---------- -FMKTLQKQH GDTFTVLLGG K---YITFIL CYP8A1h ---------- ---------- -FLTRMKEKH GDIFTILVGG R---YVTVLL CYP8B1h ---------- ---------- -FLKRMRTKH GDVFTVQLGG Q---YFTFVM CYP11A1h ---------- ---------- LHHVQNFQKY GPIYREKLGN V---ESVYVI CYP11B1h ---------- ---------- LEVHQTFQEL GPIFRYDLGG A---GMVCVM CYP11B2h ---------- ---------- LEMHQTFQEL GPIFRYNLGG P---RMVCVM CYP17h ---------- ---------- NNFFKLQKKY GPIYSVRMGT K---TTVIVG CYP19h ---------- --------IG SACNYYNRVY GEFMRVWISG E--ETLIISK CYP20h ---------- --------FL VNLHERYGPV V---SFWFGR RLV-VSLGTV CYP21A2h ---------- ---------- IYLLGLTQKF GPIYRLHLGL Q---DVVVLN CYP24h ---------- ---------- DTLVEYHKKY GKIFRMKLGS F---ESVHLG CYP26A1h ---------- ---------- -FLQMKRRKY GFIYKTHLFG R---PTVRVM CYP26B1h ---------- ---------- -FQSSRREKY GNVFKTHLLG R---PLIRVT CYP26C1h ---------- ---------- -FHSSRRERY GTVFKTHLLG R---PVIRVS CYP27A1h ---------- ---------- QLQVLYKAKY GPMWMSYLGP Q---MHVNLA CYP27B1h ---------- ---------- ELQVQGAAHF GPVWLASFGT V---RTVYVA CYP27C1h ---------- ---------- EIQQKHTREY GKIFKSHFGP Q---FVVSIA CYP39A1h ---------- ---------- -FIEKARIKY GPIFTVFAMG N---RMTFVT CYP46h ---------- --------VF LDWAKKYGPV VRVNVFHKTS VIV-TSPESV CYP51h ---------- ---------- -FLENAYEKY GPVFSFTMVG K---TFTYLL Cyp1a1 GLNTIKQALV RQGDDFKGRP D-LYSFTLIT NG---KSMTF NPDSGPVWAA Cyp1a2 GLNTIKQALV RQGDDFKGRP D-LYSFTLIT NG---KSMTF NPDSGPVWAA Cyp1b1 GESAIHQALV QQGSIFADRP P-FASFRVVS GG---RSLAF G-HYSEHWKT Cyp2a4 GQEAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGIAF S--SGERAKQ Cyp2a5 GQEAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGVVF S--SGERAKQ Cyp2a12 GYDAVKEALV DHAEEFSGRG E-QATFNTLF KG---YGVAF S--NGERAKQ Cyp2b9 GTQTIREALV DHAEAFSGRG T-IAAAQLVM QD---YGIFF A--SGQRWKT Cyp2b10 GTDTIREALV GQAEAFSGRG T-VAVVEPTF KE---YGVIF A--NGERWKT Cyp2b13 GTQTIREALV NNAEAFSGRG T-IAAAQLVM QD---YGIFF S--SGERWKT Cyp2b19 GTDTIREALV NQAEAFSGRG T-VAVLDPIV QG---YGVIF S--SGERWKT Cyp2b23 GTETIKEALV DHSDAFSGRG A-IAVIQPIV QD---YGVIF S--SGERWKT Cyp2c29 GYEAVKEALI DRGEEFAGRG S-FPMAEKMI KG---FGVVF S--NGNRWKE Cyp2c37 GYEAVKEALV DHGEEFAGRG R-FPVFDKAT NG---MGLAF S--KGNVWKN Cyp2c38 GYEAVKEALI DHGEEFSGRG N-IPMSEKIN NG---LGITF S--NGNSWKE Cyp2c39 GYEAVKEALI DHGEEFSDRG S-IPMVEKIN NG---LGIVF S--NGNRWKE Cyp2c40 GYEAIKEALI DHGEEFSGRG R-IPVFDKVS TG---KGIGF S--HGNVWKA Cyp2c44 GYDVVKEALL NQGDEFLGRG P-LPIIEDSQ KG---HGIVF S--EGERWKL Cyp2c50 GYEAVKEALV DHGEEFAGRG R-LPVFDKAT NG---MGIIF S--KGNVWKN Cyp2c54 GYEAVKEALV DHGDVFAGRG R-LPVFDKAT NG---MGIGF S--NGSVWKN Cyp2c55 GYEAVKEALD DLGEEFSGRG S-FQIFERIN ND---LGVIF S--NGTKWKE Cyp2c65 GYEAVKEAFT DHGEEFAGRG V-FPVFDKFK KN---CGVVF S--SGRTWKE Cyp2c66 GYKAVKEALI DHGEEFAGRG T-FPVADKFI RV---LGVVF S--SGRTWKE Cyp2c67 GYEAMKEAFI DHGEEFSGRG R-FPFFDKVT KG---KGIGF S--HGNVWKA Cyp2c68 GYEAMKEAFI DYGEEFSGRG R-IPVFDKVS KG---KGIGF S--HGNVWKA Cyp2c69 GYEAIKEALI DHGEVFSGRG R-FPFFDKVS KG---KGIGF S--HGNVWKA Cyp2c70 GYKAMKEALI DQGDEFSDKT D-SSLLSRTS QG---LGIVF S--NGETWKQ Cyp2d9 GLKAMKEMLL TCGEDTADRP P-VPIFEYLG VKPGSQGVVL AP-YGPEWRE Cyp2d10 GLKAMKEVLL TCGEDTADRP Q-VPIFEYLG VKPGSQGVVL AP-YGPEWRE Cyp2d11 GLKAMKEMLL TCGEDTADRP P-VPIFEYLG VKPGSQGVVL AP-YGPEWRE Cyp2d12 RMKAMKEVLL TCGEDTADRP P-VPIFEHLG FKPRSQGMIF AP-YGPEWRE Cyp2d13 GLKAVREVLV TCGEDTADRP E-MPIFQHLG YGEKAKGVVF AP-YGPEWRE Cyp2d22 GLTALREALV KHSEDTADRP P-LHFNDLLG FGPRSQGIVL AR-YGPAWRQ Cyp2d26 GLKAVRELLV TYGEDTSDRP L-MPIYNHIG YGHKSKGVIL AP-YGPEWRE Cyp2e1 GYKAVKEVLL NHKNEFSGRG D-IPVFQEYK N----KGIIF N--NGPTWKD Cyp2f2 GYQTVKEALV DKGEEFSGRG A-YPVFFNFT RG---NGIAF S--DGERWKI Cyp2g1 GHEAVKEALV DQADDFSGRG E-MPTLEKNF QG---YGLAL S--NGERWKI Cyp2j5 GLPLIKEMFT HLDQNFVNRF M-TPVRERIT GK---NGLVV S--NGQTWKE Cyp2j6 GLPLIKEALT QMEQNIMNRP L-SVMQERIS NK---NGLIF S--SGQIWKE Cyp2j7 GLPLIKEAFT DMEQNLLKRP I-IPSRKHVF KD---NGIIF S--SGQKWKE Cyp2j8 GEPLIKEALT CMGQNFLKRP I-LAARQHIF KN---NGIIS S--SGQTWKE Cyp2j9 GMPLIKEIFT QMEHNFMNRP V-TLLRKHLF NK---NGLIF S--SDQTWKE Cyp2j13 SLPLIKEAFS HLDENFINRR I-FPLQRQIF NG---NGLIF S--SGQTWKE Cyp2j12 GLPLIKEVFT NMEQNFLNRP I-TPIRKRVF NN---NGLII S--NGQTWKE cyp2j11 GLPLIKEAIT GMEQNFLKRP S-LAARQHVF KN---NGIVF S--SGQTWKE Cyp2r1 GYDVVKECLV HQSEIFADRP C-LPLFMKMT KM---GGLLN SR-YGRGWID Cyp2s1 GHDAVREALG GQAEEFSGRG T-LATLDKTF DG---HGVFF A--NGERWKQ Cyp2t4 GYEALRDALV LQADAFSGRG A-MAVFDRFT CG---NGIVF S--NGPRWHS Cyp2U1 DFHSVREALV QQAEVFSDRP R-MPLISIMT KE---KGIVF AH-YGPIWKQ Cyp2w1 GYEVVREALV GTGHELADRP P-IPIFQHIQ RG---GGIFF S--SGARWRA CYP2W1h GFEAVKEALA GPGQELADRP P-IAIFQLIQ RG---GGIFF S--SGARWRA Cyp3a11 DPETIKNVLV KECFS---VF TNRRDFGPVG IM---SKAIS IS-KDDEWKR Cyp3a13 DPDIIKTVLV KECYS---TF TNRRRFGPVG IL---KKAIS IS-ENEEWKR Cyp3a16 DPETIKNVLV KECFS---VF TNRQDFFPVG IM---SKSIS LA-KDEEWKR Cyp3a25 DPEIIKIVLV KECYS---VF TNRRFFGPVG FM---KKAIT IS-EDEEWKR Cyp3a57 DPEIIKIVLV KECYS---VF TNRRPFGPVG FL---KKSIT IS-EDEEWKR Cyp3a41 DPEMIKNVLV KECFS---VF TNRREFGPVG IM---SKAIS IS-KDEEWKR Cyp3a44 DPETIKNVLV KDCLS---VF TNRREFGPVG IM---SKAIS IS-KDEEWKR Cyp4a10 DPDYMKVILG RS----DPKA NGAYRLLAPW IG---YGLLL LN-G-QPWFQ Cyp4a12 DPDYMKLILG RS----DPKA NGSYRFLAPW IG---RGLLL LD-G-QTWFQ Cyp4a14 DPDYVKVVLG RS----DPKA SGIYQFFAPW IG---YGLLL LN-G-KKWFQ Cyp4a30 DPDYMKVILG RS----DPKV VRSYSFFAPW IG---YGLLL LN-G-KKWFQ Cyp4a29 DPDYMKVILG RA----SDPK ASLYRFLTPW LG---HGLFF LN-G-DEWFQ Cyp4b1 EPDYAKAVYS RG----DPKA AYVYDFFLQW IG---KGLLV LE-G-PKWFQ Cyp4f13 HPNFIAPLLQ AS-AAVAPKE MTLYGFLKPW LG---DGLLM SA-G-DKWSH Cyp4f14 HSDIVRSILN AS-AAVALKD VIFYSILKPW LG---DGLLV SA-G-DKWSR Cyp4f15 HPDIIRSVLN AS-ASVALKE VVFYSFLKPW LG---DGLLL SD-G-DKWSS Cyp4f16 DPAFVAPLLQ AP-ALVAPKD MTFLRFLKPW LG---DGLFL SS-G-DKWSR Cyp4f17 HPKFIGSILQ AS-AAVAPKE MIFYGFLKPW LG---DGLLV SA-G-EKWSR Cyp4f18 HPAFIKPVVL AP-ALVAPKD TVFYRFLKPW LG---DGLLM ST-G-DKWSR Cyp4f37 DPAFVAPLLL AT-ALVAPKD TTFHTFVKPW LG---DGLFL NS-G-DKWSR Cyp4f39 HPDYIKPVLG AS-AAIAPKD EFFYSFLKPW LG---DGLLI SK-G-NKWSR Cyp4f40 HPDIIRSVLS ASSAAVAPKD DIFYSFLKPW LG---DGLLV SA-G-DKWNR Cyp4v3 KAENVEVILT SS--K-QIDK SFLYKFLQPW LG---LGLLT ST-G-SKWRT Cyp4x1 DPDYAKIFLS RT----G--- ---------- -----RGLLN LD-G-PRWFQ Cyp5a1 EPDMIKQVLV ENFSN---FS NRMASGLEPK MV---ADSVL LL-RDRRWEE Cyp7a1 NSLSYHKVLC HGK-YFDWKK F-HYTTSAKA FG---HRSID PS-DGNTTEN Cyp7b1 NPFQYQYVTK NPK-QLSFQK F-SSRLSAKA FS---VKKLL TD-DDLNED- Cyp8a1 DPHSYDTVVW ELRTRLDFHP Y-AIFLMERI FD---LQLPN FN-PSEEKA- Cyp8b1 DPLSFGPIIK NTEKALDFQS Y-AKELVLKV FG---YQSVD GD-HRMIHL- Cyp11a1 DPKDASILFS CEGPNPERFL V-PPWVAYHQ YYQRPIGVLF K--SSDAWKK Cyp11b1 LPEDVEKLYQ VESTHPCRMP L-ESWIVHRE LRGLGRGVFL L--NGPEWYF Cyp11b2 LPEDAEKLHQ VESMLPRRMH L-EPWVAHRE LRGLRRGVFL L--NGPEWRL Cyp17 HYQLAREVLV KKGKEFSGRP Q-MVTLGLLS DQG--KGVAF AD-SSSSWQL Cyp19 SSSMFHVMKH SHYISRFGSK R-GLQCIGMH EN----GIIF NN-NPSLWRT Cyp20 DVLKQHFNPN KT---SDPFE TMLKSLLGYQ SG---GGSAG ED------HV Cyp21 SNRTIEEALI QKWVDFAGRP -----HMLNG KMD--LDLSL GD-YSLMWKA Cyp24 SPSLLEALYR TESAHPQRLE I-KPWKAYRD HRNEAYGLMI L--EGQEWQR Cyp26a1 GADNVRRILL GEH--RLVSV H-WPASVRTI LG---AGCLS NL-HDSSHKQ Cyp26b1 GAENVRKILL GEH--QLVST E-WPRSARVL LG---PNTVA NS-IGDIHRN Cyp26c1 GAENVRTILL GEH--RLVRS Q-WPQSAHIL LG---SHTLL GA-VGEPHRQ Cyp27a1 SAPLLEQVMR QEGKYPIRDH M-DQWKDHRD HKGLTYGIFI A--QGEQWYH Cyp27b1 DPTLVEQLLR QESHCPERCS F-SSWAEHRR RHQRACGLLT A--DGEEWQR Cyp39 EEEGINVLLK SEHVDFESAV Q-SPVYHTAW IP---KNVFS AL-HERLYAL Cyp46 KKFLMSTKYN KD---SKMYR ALQTVFGERL FG---QGLVS EC-DYGRWYK Cyp51 GSDAAALLFN SKNEDLNAEE V-YGRLTTPV FG---KGVAY DV-PNAIFLE CYP1A1h GLDTIRQALV RQGDDFKGRP D-LYTFTLIS NG---QSMSF SPDSGPVWAA CYP1A2h RLDTIRQALV RQGDDFKGRP D-LYTSTLIT DG---QSLTF STDSGPVWAA CYP1B1h GERAIHQALV QQGSAFADRP A-FASFRVVS GG---RSMAF G-HYSEHWKV CYP2A6 GHDAVREALV DQAEEFSGRG E-QATFDWVF KG---YGVVF S--NGERAKQ CYP2A7 GHDAVREALV DQAEEFSGRG E-QATFEWVF KG---YGVAF S--NGERAKQ CYP2A13 GHDAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGVAF S--NGERAKQ CYP2B6 GVEAIREALV DKAEAFSGRG K-IAMVDPFF RG---YGVIF A--NGNRWKV CYP2C8 GYEAVKEALI DNGEEFSGRG N-SPISQRIT KG---LGIIS S--NGKRWKE CYP2C9 GYEAVKEALI DLGEEFSGRG I-FPLAERAN RG---FGIVF S--NGKKWKE CYP2C18 GYEAVKEALI DHGEEFSGRG S-FPVAEKVN KG---LGILF S--NGKRWKE CYP2C19 GYEVVKEALI DLGEEFSGRG H-FPLAERAN RG---FGIVF S--NGKRWKE CYP2D6 GLAAVREALV THGEDTADRP P-VPITQILG FGPRSQGVFL AR-YGPAWRE CYP2E1h GYKAVKEALL DYKDEFSGRG D-LPAFHAHR D----RGIIF N--NGPTWKD CYP2F1 GYQAVKEALV DQGEEFSGRG D-YPAFFNFT KG---NGIAF S--SGDRWKV CYP2G2P GHEAVKEALV DQADEFSGRG E-LASIKQNF QG---HGVAL A--NGERWRI CYP2J2 GLPLIKEALI HMDQNFGNRP V-TPMREHIF KK---NGLIM S--SGQAWKE CYP2R1h GYDVVKECLV HQSEIFADRP C-LPLFMKMT KM---GGLLN SR-YGRGWVD CYP2S1h GQEAVREALG GQAEEFSGRG T-VAMLEGTF DG---HGVFF S--NGERWRQ CYP2T2P GYAALRDALV LQADAVSGRG S-MAVFERFT RG---NGILF S--NRPCWWT CYP2U1h DFHSVREALV QQAEVFSDRP R-VPLISIVT KE---KGVVF AH-YGPVWRQ CYP3A4 DPDMIKTVLV KECYS---VF TNRRPFGPVG FM---KSAIS IA-EDEEWKR CYP3A5 DPDVIRTVLV KECYS---VF TNRRSLGPVG FM---KSAIS LA-EDEEWKR CYP3A7 DPDMIKTVLV KECYS---VF TNRRPFGPVG FM---KNAIS IA-EDEEWKR CYP3A43 DPDMIKTVLV KECYS---VF TNQMPLGPMG FL---KSALS FA-EDEEWKR CYP4A11 DPDYMKVILG RS----DPKS HGSYRFLAPW IG---YGLLL LN-G-QTWFQ CYP4A22 DPDYMKVILG RS----DPKS HGSYKFLAPR IG---YGLLL LN-G-QTWFQ CYP4B1h EPDYAKAVYS RG----DPKA PDVYDFFLQW IG---RGLLV LE-G-PKWLQ CYP4F2 LPTCIKPVLF AS-AAIAPKD KFFYSFLEPW LG---DGLLL SA-G-DKWSR CYP4F3 HPTYIKPVLF AP-AAIVPKD KVFYSFLKPW LG---DGLLL SA-G-EKWSR CYP4F8 HPDIVRSVIN TS-DAITDKD IVFYKTLKPW LG---DGLLL SV-G-DKWRH CYP4F11 HPDIIRPITS AS-AAVAPKD MIFYGFLKPW LG---DGLLL SG-G-DKWSR CYP4F12 HPDTIRSITN AS-AAIAPKD NLFIRFLKPW LG---EGILL SG-G-DKWSR CYP4F22 HPDYIKPLLG AS-AAIAPKD DLFYGFLKPW LG---DGLLL SK-G-DKWSR CYP4F23P HPTFTAPVLQ AS-AAVALKD MSFYGFLKPW LG---DGLLI SA-G-DKWRW CYP4V2 NAENVEGILT SS--K-QIDK SSMYKFLEPW LG---LGLLT ST-G-NKWRS CYP4X1h DPDYAKTLLS RT----DPKS QYLQKFSPPL LG---KGLAA LD-G-PKWFQ CYP4Z1 DPDYAKILLK RQ----DPKS AVSHKILESW VG---RGLVT LD-G-SKWKK CYP5A1h EPDMIKQVLV ENFSN---FT NRMASGLEFK SV---ADSVL FL-RDKRWEE CYP7A1h NPLSYHKVLC HGK-YFDWKK F-HFATSAKA FG---HRSID PM-DGNTTEN CYP7B1h DPFQYQLVIK NHK-QLSFRV F-SNKLLEKA FS---ISQLQ KN-HDMNDE- CYP8A1h DPHSYDAVVW EPRTRLDFHA Y-AIFLMERI FD---VQLPH YS-PSDEKA- CYP8B1h DPLSFGPILK DTQRKLDFGQ Y-AKKLVLKV FG---YRSVQ GD-HEMIHS- CYP11A1h DPEDVALLFK SEGPNPERFL I-PPWVAYHQ YYQRPIGVLL K--KSAAWKK CYP11B1h LPEDVEKLQQ VDSLHPHRMS L-EPWVAYRQ HRGHKCGVFL L--NGPEWRF CYP11B2h LPEDVEKLQQ VDSLHPCRMI L-EPWVAYRQ HRGHKCGVFL L--NGPEWRF CYP17h HHQLAKEVLI KKGKDFSGRP Q-MATLDIAS NNR--KGIAF AD-SGAHWQL CYP19h SSSMFHIMKH NHYSSRFGSK L-GLQCIGMH EK----GIIF NN-NPELWKT CYP20h DVLKQHINPN KT---SDPFE TMLKSLLRYQ SG---GGSVS EN------HM CYP21A2h SKRTIEEAMV KKWADFAGRP E-PLTYKLVS RNY--PDLSL GD-YSLLWKA CYP24h SPCLLEALYR TESVP-QRLE I-KPWKAYRD YRKEGYGLLI L--EGEDWQR CYP26A1h GADNVRRILL GDD--RLVSV H-WPASVRTI LG---SGCLS NL-HDSSHKQ CYP26B1h GAENVRKILM GEH--HLVST E-WPRSTRML LG---PNTVS NS-IGDIHRN CYP26C1h GAENVRTILL GEH--RLVRS Q-WPQSAHIL LG---SHTLL GA-VGEPHRR CYP27A1h SAPLLEQVMR QEGKYPVRND M-ELWKEHRD QHDLTYGPFT T--EGHHWYQ CYP27B1h APALVEELLR QEGPRPERCS F-SPWTEHRR CRQRACGLLT A--EGEEWQR CYP27C1h DRDMVAQVLR AEGAAPQRAN M-ESWREYRD LRGRATGLIS A--EGEQWLK CYP39A1h EEEGINVFLK SKKVDFELAV Q-NIVYRTAS IP---KNVFL AL-HEKLYIM CYP46h KKFLMSTKYN KD---SKMYR ALQTVFGERL FG---QGLVS EC-NYERWHK CYP51h GSDAAALLFN SKNEDLNAED V-YSRLTTPV FG---KGVAY DV-PNPVFLE Cyp1a1 RRRLAQNALK SFSIASDPTS ASSCYLEEHV SKEANYLVSK LQKVMAEVG- Cyp1a2 RRRLAQDALK SFSIASDPTS ASSCYLEEHV SKEANHLVSK LQKAMAEVG- Cyp1b1 QRRSAYSTMR AFSTRHPRSR G---LLEGHA LAEARELVAV LVRRCAGGA- Cyp2a4 LRSFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDS FRKTNGAF-- Cyp2a5 LRRFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDS FRKTNGAF-- Cyp2a12 LRRFSIATLR DFGMGKRG-- -----VEEHI QEEAGCLIKM LQGTCGAP-- Cyp2b9 LRRFSLATMK EFGMGKRS-- -----VEERI KEEAQCLVEE LKKYQGVP-- Cyp2b10 LRRFSLATMR DFGMGKRS-- -----VEERI QEEAQCLVEE LRKSQGAP-- Cyp2b13 LRRFSLATMK EFGMGKRS-- -----VEERI KEEAQCLVEE LKKYQGAP-- Cyp2b19 LRRFSLATMR DFGMGKRS-- -----VEERI KEEAQCLVEE LKKYKGAP-- Cyp2b23 LRRFSLATMR DFGMGKRS-- -----VEERI KEEAQCLVEE LKKYEGAP-- Cyp2c29 MRRFTLMTLR NLGMGKRN-- -----IEDRV QEEAQCLVEE LRKTKGSP-- Cyp2c37 TRRFSLMTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- Cyp2c38 TRHFTLMTLR NLGMGKRN-- -----IEDRV REEAQCLVEE LRKTKGSP-- Cyp2c39 IRRFTLTTLR NLGMGKRN-- -----IEDRV QEEAQCLVEE LRKTKGSP-- Cyp2c40 TRVFTVNTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGSP-- Cyp2c44 LRRFSLMTLK NFGMGKRS-- -----LEERV QEEARCLVEE LHKTEAQP-- Cyp2c50 TRRFSLTTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- Cyp2c54 TRHFSLMTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- Cyp2c55 LRRFSIMTLR SFGMGKRS-- -----IEDRI QEEASCLVEE LRKANGSL-- Cyp2c65 MRRFSLMTLR NFGMGRRS-- -----IEDRI QEEARCLVDE LRKTKGEP-- Cyp2c66 MRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVDE LRKTKGVP-- Cyp2c67 TRVFTINTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGLP-- Cyp2c68 TRVFTVNTLR NLGMGKRT-- -----IETKV QEEAQWLMKE LKKTNGSP-- Cyp2c69 TRVFTVNTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGSP-- Cyp2c70 TRRFSLMVLR SMGMGKKT-- -----IEDRI QEEILYMLDA LRKTNGSP-- Cyp2d9 QRRFSVSTLR NFGLGKKS-- -----LEDWV TKEANHLCDA FTAQAGQP-- Cyp2d10 QRRFSVSTLR NFGLGKKS-- -----LEDWV TKEARHLCDA FTAQAGQP-- Cyp2d11 QRRFSVSTLR NFGLGKKS-- -----LEEWV TKEARHLCDA FTAQAGQP-- Cyp2d12 QRRFSLSSLR NFGLGRKS-- -----LEEWV IKEAGHLCDA FTTQAGQY-- Cyp2d13 LRRFSVSTLR NLGLGKKS-- -----LEQWV TEEAGHLCDA FTAQAGSP-- Cyp2d22 QRRFSVSTMH HFGLGKKS-- -----LEQWV TEEARCLCAA FADHTGHP-- Cyp2d26 QRRFSVSTLR DFGLSKKS-- -----LEQWV TEEAGHLCDA FTKEAEHP-- Cyp2e1 VRRFSLSILR DWGMGKQG-- -----NEARI QREAHFLVEE LKKTKGQP-- Cyp2f2 LRRFSVQILR NFGMGKRS-- -----IEERI LEEGSFLLEV LRKMEGKP-- Cyp2g1 LRRFSLTVLR NFGMGKRS-- -----IEERI QEEAGYLLEE LHKVKGAP-- Cyp2j5 QRRLALMALR NFGLGKKS-- -----LEERI QEETHHLVEA IREEGGQP-- Cyp2j6 QRRFALMTLR NFGLGKKS-- -----LEERM QEEASHLVEA IREEEGKP-- Cyp2j7 QRRFALMILK SFGLGKKS-- -----LEQRI QEEAYHLVKA MEEEKGQP-- Cyp2j8 QRRFTLMILK NFGLGKKS-- -----LEQRI QDEAHHLVEA IAEEKGRP-- Cyp2j9 QRRFALMTLR NFGLGKRS-- -----LEERI QEEAHYLVEA IRDEGGQP-- Cyp2j13 QRRFALMTLR NFGLGKKS-- -----LEHRI QEEASHLVEA IGEEEGQP-- Cyp2j12 QRRFALMTLK NFGLGKKS-- -----LEQRI QKEADCLVEA IGEEKGKP-- cyp2j11 QRKFALTILK NFGLGKKS-- -----LEQCI QEEAYHLVKA IGEEKGQP-- Cyp2r1 HRRLAVNSFH YFGSGQKS-- -----FESKI LEETWSLIDA IETYKGGP-- Cyp2s1 LRKFTLLALR DLGMGKRE-- -----GEELI QAEVQSLVEA FQKTEGRP-- Cyp2t4 LRNFALGVLR ELGVGRST-- -----IEDRI LEEAACVLDE FQATMGAP-- Cyp2U1 QRRFSHSTLR HFGLGKLS-- -----LEPRI IEEFAYVKEA MQKHGEAP-- Cyp2w1 GRQFTVRTLQ SLGVQQPS-- -----MVGKV LQELACLKGQ LDSYGGQP-- CYP2W1h ARQFTVRALH SLGVGREP-- -----VADKI LQELKCLSGQ LDGYRGRP-- Cyp3a11 YRALLSPTFT SGKLKE---- -----MFPVI EQYGDILVKY LRQKAKKGKP Cyp3a13 IRALLSPTFT SGRLKE---- -----MFPII NQFTDVLVRN MRQGLGEGKP Cyp3a16 YRALLSPTFT SGNLKE---- -----MFPVI EQYGDILVKY LRQEAEKGKP Cyp3a25 LRTLLSPTFT SGKLKE---- -----MFPIM RQYGDILVRN LRREEEKGEP Cyp3a57 LRTLLSPTFT SSKLKE---- -----MFPIM RQYGDILVRN LRREEEKEEP Cyp3a41 YRALLSPTFT SGKLKE---- -----MFPVI EQYGDILVKY LMQEAEKGKP Cyp3a44 YRALLSPTFT SGRLKE---- -----MFPVI EQYGDILVKY LRQEAEKGMP Cyp4a10 HRRMLTPAFH YDILKP---- -----YVKNM ADSIRLMLDK WERLADQDSS Cyp4a12 HRRMLTPAFH YDILKP---- -----YTEIM ADSVRVMLDK WEQIVGQDST Cyp4a14 HRRMLTPAFH YDILKP---- -----YVKIM ADSVNIMLDK WEKLDGQDHP Cyp4a30 HRRMLTPAFH YDILKP---- -----YVGIM VDSVHVMLDK WEQLVDQDCP Cyp4a29 HRRLLTPAFH YDILKP---- -----YVGIM ADSVQVMLEK WEQIACQDIT Cyp4b1 HRKLLTPGFH YDVLKP---- -----YVAIF AESTRVMLDK WEKKASENKS Cyp4f13 HRRLLTPAFH FDILKS---- -----YVKIF NKSVNIMHAK WQ-CLASKGT Cyp4f14 HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WQ-RLISDGS Cyp4f15 HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WQ-HLASGGS Cyp4f16 HRRLLTPAFH FDILKP---- -----YVKIF NQSVNIMHAK WK-HLSSEGS Cyp4f17 HRHLLTPAFH FDILKP---- -----YMKNF NKSVNIMHAK WQ-RLTTKGT Cyp4f18 HRRMLTPAFH FNILKP---- -----YVKVF NDSTNIMHAK WQ-RLASKGS Cyp4f37 HRRLLTPAFH FDILKP---- -----YVKIF NQSVNIMHAK WK-HLSSEGS Cyp4f39 HRRLLTPAFH FDILKP---- -----YMKIF NQCTNIMHAK WRRHLAEGSV Cyp4f40 HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WL-RLASGGS Cyp4v3 RRKMLTPTFH FTILEN---- -----FLDVM NEQANILVNK LEKHVNQEAF Cyp4x1 HRCLLTPAFH QDILKP---- -----CVDTM AHSVKVMLDK WEKMWTTQET Cyp5a1 VRGALMSSFS PEKLDE---- -----MTPLI SQACELLVAH LKRYAASRDA Cyp7a1 INKTFNKTLQ GDALCS---- -----LSEAM MQNLQSVMRP PGLPKSKSAV Cyp7b1 -VHRAYLLLQ GKPLDA---- -----LLETM IQEVKELFES ---QLLKITD Cyp8a1 -R--MKPTLM HRDLQA---- -----LTEAM YTNLRTVLLG --DSTEAGSG Cyp8b1 -A--STKHLM GQGLEE---- -----LNQAM LDSLSLVMLG PKGSSLGASS Cyp11a1 DRIVLNQEVM APGAIKNFVP ----LLEGVA QDFIKVLHRR IKQQN-SGNF Cyp11b1 NRLQLNPNVL SPKAVQKFVP ----LVDGIA RDFVDNLKKK MLESV-HGSF Cyp11b2 NRLRLNRNVL SPKAVQKFVP ----MVDMVA RDFLETLKEK VLQNA-RGSL Cyp17 HRKLVFSTFS LFRD-DQK-- -----LEKMI CQEANSLCDL ILTYDGES-- Cyp19 IRPFFMKALT GPGLVR---- -----MVEVC VESIKQHLDR LGEVTDTS-- Cyp20 RRKLYGDAVT ASLHSN---- -----FPLLL QLSEELLDKW LSYPETQHIP Cyp21 HKKLSRSALM LGMR--DS-- -----MEPLI EQLTQEFCER MRAQAGTP-- Cyp24 VRSAFQKKLM KPVEIMKLDK ----KINEVL ADFMGQIDEL RDERG---R- Cyp26a1 RKKVIMQAFS REALQC---- -----YVLVI AEEVSSCLEQ WLSCGER--- Cyp26b1 KRKVFSKIFS HEALES---- -----YLPKI QLVIQDTLRA WSSQPE---- Cyp26c1 RRKVLARVFS RSSLEQ---- -----FVPRL QGALRREVRS WCAAQR---- Cyp27a1 LRQALKQRLL KPDEAALYTD ----ALNEVI SDFITRLDQV RAESE-SGDQ Cyp27b1 LRSLLAPLLL RPQAAAGYAG ----TLDNVV RDLVRRLRRQ RGRGSGLPGL Cyp39 MKGKMGTFNT HHFTGP---- -----LTEEL HEQLEGLGTH G--------- Cyp46 QRKVMDLAFS RSSLVS---- -----LMETF NEKAEQLVEI LEAKADGQTP Cyp51 QKKIIKSGLN IAHFKQ---- -----YVPII EKEAKEYFQS -------WGE CYP1A1h RRRLAQNGLK SFSIASDPAS STSCYLEEHV SKEAEVLIST LQELMAGPG- CYP1A2h RRRLAQNALN TFSIASDPAS SSSCYLEEHV SKEAKALISR LQELMAGPG- CYP1B1h QRRAAHSMMR NFFTRQPRSR Q---VLEGHV LSEARELVAL LVRGSADGA- CYP2A6 LRRFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDA LRGTGGAN-- CYP2A7 LLRFAIATLR DFGVGKRG-- -----IEERI QEESGFLIEA IRSTHGAN-- CYP2A13 LRRFSIATLR GFGVGKRG-- -----IEERI QEEAGFLIDA LRGTHGAN-- CYP2B6 LRRFSVTTMR DFGMGKRS-- -----VEERI QEEAQCLIEE LRKSKGAL-- CYP2C8 IRRFSLTNLR NFGMGKRS-- -----IEDRV QEEAHCLVEE LRKTKASP-- CYP2C9 IRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTKASP-- CYP2C18 IRRFCLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTNASP-- CYP2C19 IRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTKASP-- CYP2D6 QRRFSVSTLR NLGLGKKS-- -----LEQWV TEEAACLCAA FANHSGRP-- CYP2E1h IRRFSLTTLR NYGMGKQG-- -----NESRI QREAHFLLEA LRKTQGQP-- CYP2F1 LRQFSIQILR NFGMGKRS-- -----IEERI LEEGSFLLAD VRKTEGEP-- CYP2G2P LR-FPLTILR DFGMGKRS-- -----IEERI QEEASYLLEE FRKTKGAP-- CYP2J2 QRRFTLTALR NFGLGKKS-- -----LEERI QEEAQHLTEA IKEENGQP-- CYP2R1h HRRLAVNSFR YFGYGQKS-- -----FESKI LEETKFFNDA IETYKGRP-- CYP2S1h LRKFTMLALR DLGMGKRE-- -----GEELI QAEARCLVET FQGTEGRP-- CYP2T2P LRNFALGALK KFGLGTRT-- -----VEARV LEEAACLLDE FQATIGAP-- CYP2U1h QRKFSHSTLR HFGLGKLS-- -----LEPKI IEEFKYVKAE MQKHGEDP-- CYP3A4 LRSLLSPTFT SGKLKE---- -----MVPII AQYGDVLVRN LRREAETGKP CYP3A5 IRSLLSPTFT SGKLKE---- -----MFPII AQYGDVLVRN LRREAEKGKP CYP3A7 IRSLLSPTFT SGKLKE---- -----MVPII AQYGDVLVRN LRREAETGKP CYP3A43 IRTLLSPAFT SVKFKE---- -----MVPII SQCGDMLVRS LRQEAENSKS CYP4A11 HRRMLTPAFH YDILKP---- -----YVGLM ADSVRVMLDK WEELLGQDSP CYP4A22 HRRMLTPAFH NDILKP---- -----YVGLM ADSVRVMLDK WEELLGQDSP CYP4B1h HRKLLTPGFH YDVLKP---- -----YVAVF TESTRIMLDK WEEKAREGKS CYP4F2 HRRMLTPAFH FNILKP---- -----YMKIF NESVNIMHAK WQ-LLASEGS CYP4F3 HRRMLTPAFH FNILKP---- -----YMKIF NESVNIMHAK WQ-LLASEGS CYP4F8 HRRLLTPAFH FNILKP---- -----YIKIF SKSANIMHAK WQ-RLAMEGS CYP4F11 HRRMLTPAFH FN-LKP---- -----YMKIF NKSVNIMHDK WQ-RLASEGS CYP4F12 HRRMLTPAFH FNILKS---- -----YITIF NKSANIMLDK WQ-HLASEGS CYP4F22 HRRLLTPAFH FDILKP---- -----YMKIF NQSADIMHAK WR-HLAEGSA CYP4F23P HRHLLTPAFH FKILKP---- -----YVKIF NESTNIMHAK WQ-RLALEGS CYP4V2 RRKMLTPTFH FTILED---- -----FLDIM NEQANILVKK LEKHINQEAF CYP4X1h HRRLLTPGFH FNILKA---- -----YIEVM AHSVKMMLDK WEKICSTQDT CYP4Z1 HRQIVKPGFN ISILKI---- -----FITMM SESVRMMLNK WEEHIAQNSR CYP5A1h VRGALMSAFS PEKLNE---- -----MVPLI SQACDLLLAH LKRYAESGDA CYP7A1h INDTFIKTLQ GHALNS---- -----LTESM MENLQRIMRP PVSSNSKTAA CYP7B1h -LHLCYQFLQ GKSLDI---- -----LLESM MQNLKQVFEP ---QLLKTTS CYP8A1h -R--MKLTLL HRELQA---- -----LTEAM YTNLHAVLLG --DATEAGSG CYP8B1h -A--STKHLR GDGLKD---- -----LNETM LDSLSFVMLT SKGWSLDASC CYP11A1h DRVALNQEVM APEATKNFLP ----LLDAVS RDFVSVLHRR IKKAG-SGNY CYP11B1h NRLRLNPEVL SPNAVQRFLP ----MVDAVA RDFSQALKKK VLQNA-RGSL CYP11B2h NRLRLNPDVL SPKAVQRFLP ----MVDAVA RDFSQALKKK VLQNA-RGSL CYP17h HRRLAMATFA LFKDGDQK-- -----LEKII CQEISTLCDM LATHNGQS-- CYP19h TRPFFMKALS GPGLVR---- -----MVTVC AESLKTHLDR LEEVTNES-- CYP20h RKKLYENGVT DSLKSN---- -----FALLL KLSEELLDKW LSYPETQHVP CYP21A2h HKKLTRSALL LGIR--DS-- -----MEPVV EQLTQEFCER MRAQPGTP-- CYP24h VRSAFQKKLM KPGEVMKLDN ----KINEVL ADFMGRIDEL CDERG---H- CYP26A1h RKKVIMRAFS REALEC---- -----YVPVI TEEVGSSLEQ WLSCGER--- CYP26B1h KRKVFSKIFS HEALES---- -----YLPKI QLVIQDTLRA WSSHPE---- CYP26C1h RRKVLARVFS RAALER---- -----YVPRL QGALRHEVRS WCAAGG---- CYP27A1h LRQALNQRLL KPAEAALYTD ----AFNEVI DDFMTRLDQL RAESA-SGNQ CYP27B1h LRSLLAPLLL RPQAAARYAG ----TLNNVV CDLVRRLRRQ RGRGTGPPAL CYP27C1h MRSVLRQRIL KPKDVAIYSG ----EVNQVI ADLIKRIYLL RSQAE-DGET CYP39A1h LKGKMGTVNL HQFTGQ---- -----LTEEL HEQLENLGTH G--------- CYP46h QRRVIDLAFS RSSLVS---- -----LMETF NEKAEQLVEI LEAKADGQTP CYP51h QKKMLKSGLN IAHFKQ---- -----HVSII EKETKEYFES -------WGE Cyp1a1 H--FDPYKYL VVSVANVICA ICFGQRYDHD DQE---LLSI VNLSNEFGEV Cyp1a2 H--FEPVSQV VESVANVIGA MCFGKNFPRK SEE---MLNI VNNSKDFVEN Cyp1b1 F--LDPTQPV IVAVANVMSA VCFGCRYNHD DAE---FLEL LSHNEEFGRT Cyp2a4 ---IDPTFYL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGSLQF Cyp2a5 ---IDPTFYL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGSFQF Cyp2a12 ---IDPTIYL SKTASNVISS IVFGDRFNYE DKE---FLSL LQMMGQVNKF Cyp2b9 ---LDPTFLF QCITANIICS IVFGERFDYT DDQ---FLHL LNLMYKIFSL Cyp2b10 ---LDPTFLF QCITANIICS IVFGERFEYT DRQ---FLRL LELFYQTFSL Cyp2b13 ---LDPTFFF QCVTANIICS IVFGERFDYT DEQ---FLRL LNLMYQIYSL Cyp2b19 ---LNPTFYF QCIVANIICS IVFGERFDYK DHQ---FLHL LNLIYQTFSL Cyp2b23 ---LDPTFLF QCITANIICS IVFGERFDYT DHQ---FLHL LDLFYQTLSL Cyp2c29 ---CDPTFIL SCAPCNVICS IIFQNRFDYK DKE---FLIL MDKINENVKI Cyp2c37 ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL MEKLNEITKI Cyp2c38 ---CDPTFIL SCAPCNVICS IIFQDRFHYK DKD---FLML MKKLNENVKI Cyp2c39 ---CDPTFIL SCAPCNVICS IIFQDRFDYK DKD---FLML MEKLNENVKI Cyp2c40 ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI Cyp2c44 ---FDPTFIL ACAPCNVICS ILFNERFPYN DKT---FLNL MDLLNKNFYQ Cyp2c50 ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL MEKLNEITKI Cyp2c54 ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL LEKLDEISKI Cyp2c55 ---CDPTFIL SCAPSNVICS VIFHNRFDYK DEK---FLNL MERLNENFKI Cyp2c65 ---CDPTFIL GCAPCNVICS IVFQNRFDYK DQE---FLTF LDILNENVEI Cyp2c66 ---CDPTFIL GCAPCNVICS IVFQNRFDYK DQE---FLTF IDILNENVEI Cyp2c67 ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI Cyp2c68 ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI Cyp2c69 ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI Cyp2c70 ---CDPSFLL ACVPCNVIST VIFQHRFDYN DQT---FQDF MENFHRKIEI Cyp2d9 ---INPNPML NKSTCNVIAS LIFARRFEYE DPF---LIRM LKVLEQSLTE Cyp2d10 ---INPNTML NNAVCNVIAS LIFARRFEYE DPY---LIRM QKVLEDSLTE Cyp2d11 ---INPNPML NKSTCNVIAS LIFARRFEYE DPF---LIRM LKMLKECFTE Cyp2d12 ---INPNTML KKATCNVIAS LIFARRFEYE DPY---LIRM LKVLEDSLTE Cyp2d13 ---LDPYTLL NKAVCNVIAS LIYARRFEYG DPD---FIKM LKILKENMGE Cyp2d22 ---FSPNTLL DKAVCNVIAS LLYACRFEYD DPR---FIRL LGLLKETLKE Cyp2d26 ---FNPSPLL SKAVSNVIAS LIYARRFEYE DPF---FNRM LKTLKESLGE Cyp2e1 ---FDPTFLI GCAPCNVIAD ILFNKRFDYD DKK---CLEL MSLFNENFYL Cyp2f2 ---FDPVFIL SRSVSNIICS VVFGSRFDYD DER---LLTI XHFINDNFKI Cyp2g1 ---IDPTLYL SRTVSNVICS VVFGKRFDYQ DQR---FQSL MRMINESFVE Cyp2j5 ---FNPHLKL INAVSNIICS VTFGERFDYE DCQ---FQEL LQLLDETMHL Cyp2j6 ---FNPHFSI NNAVSNIICS VTFGERFDYH DSR---FQEM LRLLDEVMYL Cyp2j7 ---FDPHFRI NSAVSNIICS INFGERFEYG DNK---FQEL LKITNETLSA Cyp2j8 ---FDPHFMI NNAVSNIICS ITIGERFEYE DNQ---FQEL LKLADETLCL Cyp2j9 ---FDPHFNI SNAVSNIICS ITFGERFDYH DSQ---FQEM LRLLDEAMCL Cyp2j13 ---FDPHFKI YSAVSNIICS ITFGERFEYH DSQ---FQEL LQLLDKAMYL Cyp2j12 ---FDPHFKI NSAVSNIICT FAFGERFEYE DSH---FHEL LRLLDEATCL cyp2j11 ---FDPHFRI NNAVGNIICS IIFGERFEYD DNQ---FQEL LKLADEIICS Cyp2r1 ---FDLKQLI TNAVSNITNL ILFGERFTYE DTD---FQHM IELFSENVEL Cyp2s1 ---FNPSMLL AQATSNVVCS LVFGIRLPYD DKE---FQAV IQAASGTLLG Cyp2t4 ---FDPQQLL DSAVSNVICT VVFGKRYDYG DPE---FRRL LNLFSDNFCI Cyp2U1 ---FSPFPII SNAVSNIICS LCFGQRFDYT NKE---FKKV LDFMSRGLEI Cyp2w1 ---LP-LALL GWAPCNITFT LLFGQRFDYQ DPV---FVSL LSLIDQVMVL CYP2W1h ---FP-LALL GWAPSNITFA LLFGRRFDYR DPV---FVSL LGLIDEVMVL Cyp3a11 ---VTMKDVL GAYSMDVITS TSFGVNVDSL NNP------- ----EDPFVE Cyp3a13 ---TSMKDIF GAYSMDVITA TSFGVNIDSL NNP------- ----QDPFVE Cyp3a16 ---VAVKDVL GAYSMDVIIS TTFGVNIDSL NNP------- ----EDPFVE Cyp3a25 ---ISMKDIF GAYSMDVITG TSFGVNVDSL NNP------- ----QDPFVQ Cyp3a57 ---INMKDIF GAYSMDVITG TSCGVNIDSL NNP------- ----QDPFVQ Cyp3a41 ---VTMKDVL GAYSIDVITS TSFGVNVDSL NNP------- ----EDPFVE Cyp3a44 ---VAMKDVL GAYSMDVITS TSFGVNVDSL NNP------- ----EDPFVE Cyp4a10 ---IEIFQHI SLMTLDTVMK CAFSHKGSVQ VDG--NYRTY LQAIGDLNNL Cyp4a12 ---LEIFRHI TLMTLDTIMK CAFSHEGSVQ LDR--KYKSY IQAVEDLNDL Cyp4a14 ---LEIFHCV SLMTLDTVMK CAFSYQGSVQ LDE--NSKLY TKAVEDLNNL Cyp4a30 ---LEIYQDI SLMTMETMMK CAFSYQGSVQ LE---NSKSY IKAVEDLTHL Cyp4a29 ---LEIFHPI SLMMLDTIMK YAFSYQGSVQ LDRSRSSQAY LQAVSDLNNL Cyp4b1 ---FDIFCDV GHMALDTLMK CTFGKGDSGL SHS---DNSY YLAVSDLTLL Cyp4f13 S-RLDMFEHI SLMTLDSLQK CIFSVDSNCQ ESD----SKY IAAILELSSL Cyp4f14 A-RLDMFEHV SLMTLDSLQK CVFSFDSNCQ EKS----SEY IAAILELSAL Cyp4f15 A-RLDVFENI SLMTLDSLQK CVFSFDSNCQ ENP----SEY ISAILELSAL Cyp4f16 A-RLEMFEHI SLMTLDSLQK CLFGFDSNCQ ESP----SEY ISAILELSSL Cyp4f17 A-CLDMLEHI SLMTLDSLQN CVFSFDSNCQ ESP----SEY IAAIQELSSL Cyp4f18 A-YLNMFEHI SLMTLDSLQK CVFSFDSNCQ EKP----SEY ITAILELSAL Cyp4f37 A-RLEMFEHI SLMTLDSLQK CLFGFDSNCQ ESP----SEY ISAILELSSL Cyp4f39 T-SFDMFEHI SLMTLDSLQK CVFSYNSDCQ ESM----SDY ISSIIELSAL Cyp4f40 T-RLNMFENI SLMTLDTLQK CVFSFNSNCQ EKP----SQY IAAILELSTL Cyp4v3 N----CFFYI TLCALDIICE TAMGKNIGAQ SNN---DSEY VRTVYRMSDM Cyp4x1 T--IEVFEHI NLMTLDIIMK CAFGQETNCQ INS--TYESY VKATFELGEI Cyp5a1 F-NIQRCYC- -CYTIDVVAS VAFGTQVDSQ NSP------- ----EDPFVQ Cyp7a1 WVTEGMYAFC YRVMFEAGYL TLFGKDISK- ---------- --TDTQRAFI Cyp7b1 WNTERIFAFC GSLVFEITFA TLYGKILAG- ---------- --NKKQ--II Cyp8a1 WQETGLLEFS YNALLSAGYL TLYGVEASPR THE------- S-QAQDRVHS Cyp8b1 WCEDGLFHFC YRILFKAGFL SLFGYTKD-- ---------- --KQQDLDEA Cyp11a1 S--GVISDDL FRFSFESISS VIFGERMGML EEI---VDPE AQRFINAVY- Cyp11b1 S--MDFQSSV FNYTIEASHF VLFGERLGLI GRD---LSPD SLKFLHTLH- Cyp11b2 T--MDVQQSL FNYTIEASNF ALFGERLGLL GHD---LSPG SLKFIHALH- Cyp17 ---RDLSTLI FKSVINIICT ICFNISFENK DPI---LTTI QTFTEGIVDV Cyp19 ---GYVDVLT LMRHIMLDTS NMLFLGIPLD ESA---IVKK IQGYFNAWQA Cyp20 ---LS-QHML GFALKFVTRM VLG----STF EDE----QEV IRFQKIHGTV Cyp21 ---VAIHKEF SFLTCSIISC LTFGD---KD STL---VQTL HDCVQDLLQA Cyp24 I--QDLYSEL NKWSFESICL VLYEKRFGLL QKD---TEEE ALTFIAAIK- Cyp26a1 --GLLVYPEV KRLMFRIAMR ILLGCEPGPA G--------- --GGEDEQQL Cyp26b1 --AINVYQEA QRLTFRMAVR VLLGFSIPEE ---------- -----DLGHL Cyp26c1 --PVAVYQAA KALTFRMAAR ILLGLQLDEA ---------- -----RCTEL Cyp27a1 V--PDMAHLL YHLALEAITY ILFEKRIGCL KPS---IPED TAAFIRSVA- Cyp27b1 V--LDVAGEF YKFGLESIGA VLLGSRLGCL EAE---VPPD TETFIHAVG- Cyp39 --TMDLNDFV RYLLYPATLN TLFKKGLFLT ---------- --DKRTIKEF Cyp46 ---VSMQDML TCATIDILAK AAFGMETSML LGA----QKP LSQAVKVMLE Cyp51 SGERNVFEAL SELIILTASH CLHGKEIRS- --Q------- L-NEKVAQLY CYP1A1h H--FNPYRYV VVSVTNVICA ICFGRRYDHN HQE---LLSL VNLNNNFGEV CYP1A2h H--FDPYNQV VVSVANVIGA MCFGQHFPES SDE---MLSL VKNTHEFVET CYP1B1h F--LDPRPLT VVAVANVMSA VCFGCRYSHD DPE---FREL LSHNEEFGRT CYP2A6 ---IDPTFFL SRTVSNVISS IVFGDRFDYK DKE---FLSL LRMMLGIFQF CYP2A7 ---IDPTFFL SRTVSNVISS IVFGDRFDYE DKE---FLSL LSMMLGIFQF CYP2A13 ---IDPTFFL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGRFQF CYP2B6 ---MDPTFLF QSITANIICS IVFGKRFHYQ DQE---FLKM LNLFYQTFSL CYP2C8 ---CDPTFIL GCAPCNVICS VVFQKRFDYK DQN---FLTL MKRFNENFRI CYP2C9 ---CDPTFIL GCAPCNVICS IIFHKRFDYK DQQ---FLNL MEKLNENIKI CYP2C18 ---CDPTFIL GCAPCNVICS VIFHDRFDYK DQR---FLNL MEKFNENLRI CYP2C19 ---CDPTFIL GCAPCNVICS IIFQKRFDYK DQQ---FLNL MEKLNENIRI CYP2D6 ---FRPNGLL DKAVSNVIAS LTCGRRFEYD DPR---FLRL LDLAQEGLKE CYP2E1h ---FDPTFLI GCAPCNVIAD ILFRKHFDYN DEK---FLRL MYLFNENFHL CYP2F1 ---FDPTFVL SRSVSNIICS VLFGSRFDYD DER---LLTI IRLINDNFQI CYP2G2P ---IDPIFLL SRTVSNVISS VVFRSRFDYE DKQ---FLNL LRLINESFIE CYP2J2 ---FDPHFKI NNAVSNIICS ITFGERFEYQ DSW---FQQL LKLLDEVTYL CYP2R1h ---FDFKQLI TNAVSNITNL IIFGERFTYE DTD---FQHM IELFSENVEL CYP2S1h ---FDPSLLL AQATSNVVCS LLFGLRFSYE DKE---FQAV VRAAGGTLLG CYP2T2P ---FDPVRLL DNAVSNVICS LVFGNRYRYG DPE---FLRL LNLFSDNFCI CYP2U1h ---FCPFSII SNAVSNIICS LCFGQRFDYT NSE---FKKM LGFMSRGLEI CYP3A4 V-TLKDVFG- -AYSMDVITS TSFGVNIDSL NNP------- ----QDPFVE CYP3A5 V-TLKDIFG- -AYSMDVITG TSFGVNIDSL NNP------- ----QDPFVE CYP3A7 V-TLKHVFG- -AYSMDVITS TSFGVSIDSL NNP------- ----QDPFVE CYP3A43 I-NLKEDFFG -AYTMDVITG TLFGVNLDSL NNP------- ----QDPFLK CYP4A11 ---LEVFQHV SLMTLDTIMK CAFSHQGSIQ VDR--NSQSY IQAISDLNNL CYP4A22 ---LEVFQHV SLMTLDTIMK SAFSHQGSIQ VDR--NSQSY IQAISDLNSL CYP4B1h ---FDIFCDV GHMALNTLMK CTFGRGDTGL GHR---DSSY YLAVSDLTLL CYP4F2 A-CLDMFEHI SLMTLDSLQK CVFSFDSHCQ EKP----SEY IAAILELSAL CYP4F3 A-RLDMFEHI SLMTLDSLQK CVFSFDSHCQ EKP----SEY IAAILELSAL CYP4F8 T-CLDVFEHI SLMTLDSLQK CIFSFDSNCQ EKP----SEY ITAIMELSAL CYP4F11 A-RLDMFEHI SLMTLDSLQK CVFSFESNCQ EKP----SEY IAAILELSAF CYP4F12 S-RLDMFEHI SLMTLDSLQK CIFSFDSHCQ ERP----SEY IATILELSAL CYP4F22 V-SLDMFEHI SLMTLDSLQK CVFSYNSNCQ EKM----SDY ISAIIELSAL CYP4F23P V-RLEMFEHI SLMTLDSLQK CIFSFDSNCQ EKP----SEY IDAILELSAL CYP4V2 N----CFFYI TLCALDIICE TAMGKNIGAQ SND---DSEY VRAVYRMSEM CYP4X1h S--VEVYEHI NSMSLDIIMK CAFSKETNCQ TNS--THDPY AKAIFELSKI CYP4Z1 ---LELFQHV SLMTLDSIMK CAFSHQGSIQ LD----RSSY LKAVFNLSKI CYP5A1h F-DIQRCYC- -NYTTDVVAS VPFGTPVDSW QAP------- ----EDPFVK CYP7A1h WVTEGMYSFC YRVMFEAGYL TIFGRDLTR- ---------- --RDTQKAHI CYP7B1h WDTAELYPFC SSIIFEITFT TIYGKVIVC- ---------- --DNNK--FI CYP8A1h WHEMGLLDFS YSFLLRAGYL TLYGIEALPR THE------- S-QAQDRVHS CYP8B1h WHEDSLFRFC YYILFTAGYL SLFGYTKD-- ---------- --KEQDLLQA CYP11A1h S--GDISDDL FRFAFESITN VIFGERQGML EEV---VNPE AQRFIDAIY- CYP11B1h T--LDVQPSI FHYTIEASNL ALFGERLGLV GHS---PSSA SLNFLHALE- CYP11B2h T--LDVQPSI FHYTIEASNL ALFGERLGLV GHS---PSSA SLNFLHALE- CYP17h ---IDISFPV FVAVTNVISL ICFNTSYKNG DPE---LNVI QNYNEGIIDN CYP19h ---GYVDVLT LLRRVMLDTS NTLFLRIPLD ESA---IVVK IQGYFDAWQA CYP20h ---LS-QHML GFAMKSVTQM VMG----STF EDD----QEV IRFQKNHGTV CYP21A2h ---VAIEEEF SLLTCSIICY LTFGDKI-KD DNL---MPAY YKCIQEVLKT CYP24h V--EDLYSEL NKWSFESICL VLYEKRFGLL QKN---AGDE AVNFIMAIK- CYP26A1h --GLLVYPEV KRLMFRIAMR ILLGCEPQLA G--------- --DGDSEQQL CYP26B1h --AINVYQEA QKLTFRMAIR VLLGFSIPEE ---------- -----DLGHL CYP26C1h --PVSVYDAS KALTFRMAAR ILLGLRLDEA ---------- -----QCATL CYP27A1h V--SDMAQLF YYFALEAICY ILFEKRIGCL QRS---IPED TVTFVRSIG- CYP27B1h V--RDVAGEF YKFGLEGIAA VLLGSRLGCL EAQ---VPPD TETFIRAVG- CYP27C1h V--TNVNDLF FKYSMEGVAT ILYESRLGCL ENS---IPQL TVEYIEALEL CYP39A1h --TMDLNNLV RHLLYPVTVN MLFNKSLFST ---------- --NKKKIKEF CYP46h ---VSMQDML TYTAMDILAK AAFGMETSML LGA----QKP LSQAVKLMLE CYP51h SGEKNVFEAL SELIILTASH CLHGKEIRS- --Q------- L-NEKVAQLY Cyp1a1 T-GS---GYP ADFIP----- VLRYLPNSS- ---------- -----LDAFK Cyp1a2 V-TS---GNA VDFFP----- VLRYLPNPA- ---------- -----LKRFK Cyp1b1 V-GA---GSL VDVLP----- WLQLFPNPVR TT-------- -----FRKFE Cyp2a4 T-AT-SMGQV YEMFS----S VMKHLPGP-- ---------- -----QQQAF Cyp2a5 T-AT-SMGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF Cyp2a12 A-AS-PTGQL YDMFH----S VMKYLPGP-- ---------- -----QQQII Cyp2b9 L-SS-FSGQM FELFS----G FLKYFPGV-- ---------- -----HRQIV Cyp2b10 I-SS-FSSQM FELFS----G FLKYFPGA-- ---------- -----HRQIS Cyp2b13 L-RS-FSCQM FELFS----G LLKYFPGV-- ---------- -----HRQIA Cyp2b19 M-SS-LSSQV FELFS----A ILKYFPGA-- ---------- -----HRQIS Cyp2b23 I-SS-FSSQL FELFS----A VMKYFPGT-- ---------- -----HRQIS Cyp2c29 L-SS-PWLQV CNSFPS---- LIDYCPGS-- ---------- -----HHKIV Cyp2c37 L-SS-PWLQI CNTYPA---- LLDYCPGS-- ---------- -----HKQFF Cyp2c38 L-SS-PWLQV CNNFPL---- LIDYCPGS-- ---------- -----HHKVL Cyp2c39 L-SS-PWLQV CNNFPL---- LIDYCPGS-- ---------- -----HHKVL Cyp2c40 L-SS-PGCQI FNAVPI---- LIDYCPGS-- ---------- -----HNKLF Cyp2c44 L-NS-IWIQM YNLWPT---- IMKYIPGK-- ---------- -----HREFS Cyp2c50 M-ST-PWLQV CNTFPV---- LLDYCPGS-- ---------- -----HNKVF Cyp2c54 L-ST-PWLQV CNTFPA---- LLDYCPGS-- ---------- -----HNQFF Cyp2c55 L-NS-PWMQV YNALPT---- LINYLPGS-- ---------- -----HNKVI Cyp2c65 L-SS-PWIQI CNNFPA---- VIDYLPGR-- ---------- -----HRKLH Cyp2c66 L-SS-PWIQV CNNFPA---- IIDYLPGR-- ---------- -----HRKLL Cyp2c67 L-SS-PGCQI FNAVPI---- LIDYCPGR-- ---------- -----HNKFF Cyp2c68 L-SS-PECQI FNAVPI---- LIDYCPGS-- ---------- -----HNKFL Cyp2c69 L-SS-PGCQI FNAVPI---- LIDYCPGR-- ---------- -----HNKFF Cyp2c70 L-AS-PWSQL CSAYP----- ILYYLPGI-- ---------- -----HNRFL Cyp2d9 V-SG-LIPEV LNAFP----I LLRIP-RL-- ---------- -----ADKAL Cyp2d10 I-SL-AYSEV LNMFP----I LLRIP-GL-- ---------- -----PGKVF Cyp2d11 I-SG-FIPGV LNEFP----I FLRIP-GL-- ---------- -----ADMVF Cyp2d12 L-SG-LIPEV INTFP----I LLHIP-RL-- ---------- -----ADKFL Cyp2d13 N-TG-LFPEV LNTFP----I LLHIP-GL-- ---------- -----ADKVF Cyp2d22 E-AG-FLPMF LNVFP----M LLRIP-GL-- ---------- -----VGKVF Cyp2d26 D-TG-FVGEV LNAIP----M LLHIP-GL-- ---------- -----PDKAF Cyp2e1 L-ST-PWIQA YNYFS----D YLQYLPGS-- ---------- -----HRKVM Cyp2f2 M-SS-PWGEM YNIFP----S VLDWIPGP-- ---------- -----HKRLF Cyp2g1 M-SK-PWAQL YDMYW----K VMQYFPGR-- ---------- -----HNYLY Cyp2j5 M-GS-SAGQL YNGFP----C IMKYLPGP-- ---------- -----HQKIF Cyp2j6 E-TT-MISQL YNIFP----W IMKYIPGS-- ---------- -----HQKVF Cyp2j7 E-TS-MMLVL YNALP----S IMKYLPGP-- ---------- -----HQTVF Cyp2j8 E-AS-KVLML YNVFP----S IFKYLPGP-- ---------- -----HQKLF Cyp2j9 E-SS-MMCQL YNIFP----R ILQYLPGS-- ---------- -----HQTLF Cyp2j13 G-TTSLMVHL YNIFP----W ITKHLPGQ-- ---------- -----HQTLL Cyp2j12 E-AS-MMCQL YNVFP----S IIQYVPGS-- ---------- -----HQTVL cyp2j11 E-AS-MMSVL YNVFP----S IFKYLPGP-- ---------- -----QQKLF Cyp2r1 A-AS-APVFL YNAFP----W IGILPFGK-- ---------- -----HQRLF Cyp2s1 I-SS-PWGQA YEMFS----W LLQPLPGP-- ---------- -----HTQLQ Cyp2t4 M-SS-RWAEI YNMFP----S FMDWIPGP-- ---------- -----HNRIF Cyp2U1 C-LH-SQLFL INICP----W FYYLPFGP-- ---------- -----FKELR Cyp2w1 L-GS-PGIQL FNTFP----R LGAFLRL--- ---------- -----HRPVL CYP2W1h L-GS-PGLQL FNVYP----W LGALLQL--- ---------- -----HRPVL Cyp3a11 KAKKLLRFDF FDPL----LF SVVLFP---- ---------- -------FLT Cyp3a13 KIKKLLKFDI FDPL----FL SVTLFP---- ---------- -------FLT Cyp3a16 NAKKVLRFDY FDPL----SL SVALFP---- ---------- -------FLT Cyp3a25 KAKKILKFKV FDPF----LL SIILFP---- ---------- -------FLT Cyp3a57 KIKKILKFKF FDPF----LL SVVLFP---- ---------- -------FLT Cyp3a41 KAKGILRVDF FDPL----VF SVVLFP---- ---------- -------FLT Cyp3a44 EAKKFLRVDF FDPL----LF SVVLFP---- ---------- -------LLT Cyp4a10 FHSRVRNIFH QNDT----IY KLS------- ---------- ---SNGRLAK Cyp4a12 VFSRVRNIFH QNDI----IY RVS------- ---------- ---SNGCKAN Cyp4a14 TFFRLRNAFY KYNI----IY NMS------- ---------- ---SDGRLSH Cyp4a30 IYLRVRNGFH QNNT----IY SLSSFRA--M ES-------- HIFTNGRSFY Cyp4a29 VTSRMKNVFL HNDI----IY NLT------- ---------- ---SHSRRTN Cyp4b1 MQQRIDSFQY HNDF----IY WLTP------ ---------- ----HGRRFL Cyp4f13 VVKRHRQPFL YLDL----LY YLTA------ ---------- ----DGRRFR Cyp4f14 VAKRHQQPLM FMDL----LY NLTP------ ---------- ----DGMRFR Cyp4f15 VTKRYHQLLL HIDS----LY QLTC------ ---------- ----SGRRFH Cyp4f16 IIKRSLQLFL FVDF----LY YHTA------ ---------- ----DGRRFR Cyp4f17 IVKRHHQPFL YLDF----LY YCTA------ ---------- ----DGRRFR Cyp4f18 VARRHQRLLL HVDL----FY YLTH------ ---------- ----DGMRFR Cyp4f37 VIKRSHQLFL FVDF----LY YHTA------ ---------- ----DGRRFR Cyp4f39 VVRRQYRLHH YLDF----MY YLTA------ ---------- ----DGRRFR Cyp4f40 AVKRNEQLLM HVDL----LY RLTP------ ---------- ----DGMRFY Cyp4v3 IYRRMKMPWL WFDL----WY LVFK------ ---------- ----EGRDHK Cyp4x1 ISSRLYNFWH HHDI----IF KLS------- ---------- ---PKGHCFQ Cyp5a1 HCRRASTFCI PRPL----LV LILSFP---- ---------- -------SIM Cyp7a1 QNNLDSFKQF DQVFP----- ---------- ---------- -----ALVAG Cyp7b1 SELRDDFFKF DDMFP----- ---------- ---------- -----YLVSD Cyp8a1 ADVFHTFRQL DLLLP----- ---------- ---------- -----KLARG Cyp8b1 DELFRKFRRF DFLFP----- ---------- ---------- -----RFVYS Cyp11a1 --QMFHTSVP MLNLP---PD FFRLLRTK-- ---------- ----TWKDHA Cyp11b1 --SMFKTTTQ LLYLP---RS LTRWTSTR-- ---------- ----VWKENL Cyp11b2 --SMFKSTSQ LLFLP---KS LTRWTSTR-- ---------- ----VWKEHF Cyp17 L-GHS---DL VDIFP----- WLKIFPNKN- ---------- -----LEMIK Cyp19 LLIK---PNI FFKIS----W LYRKYERS-- ---------- -----VKDLK Cyp20 WSEIGKGFLD GSLD----KN TTR------- ---------- ----K-KQYQ Cyp21 W-NHWS-IQI LTIIP----- LLRFLPNPG- ---------- -----LQKLK Cyp24 --TMMSTFGK MMVTP---VE LHKRLNTK-- ---------- ----VWQAHT Cyp26a1 VEAFEEMTRN LFSLPI---- ---------- ---------- -----DVPFS Cyp26b1 FEVYQQFVEN VFSLPV---- ---------- ---------- -----DLPFS Cyp26c1 AHTFEQLVEN LFSLPL---- ---------- ---------- -----DVPFS Cyp27a1 --IMFQNSVY ITFLP---KW TRPLLP---- ---------- ----FWKRYL Cyp27b1 --SVFVSTLL TMAMP---NW LHHLIPG--- ---------- ----PWARLC Cyp39 YQQFKTYDEG FEYGS----- ---------- ---------- -----QLPEW Cyp46 GISASRNTLA KFMP----GK RKQ------- ---------- ----L-REIR Cyp51 ADLDGGFTHA AWLLPA---- ---------- ---------- -----WLPLP CYP1A1h V-GS---GNP ADFIP----- ILRYLPNPS- ---------- -----LNAFK CYP1A2h A-SS---GNP LDFFP----- ILRYLPNPA- ---------- -----LQRFK CYP1B1h V-GA---GSL VDVMP----- WLQYFPNPVR TV-------- -----FREFE CYP2A6 T-ST-STGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF CYP2A7 T-ST-STGQL YEMFS----S LMKHLPGP-- ---------- -----QQQAF CYP2A13 T-GT-STGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF CYP2B6 I-SS-VFGQL FELFS----G FLKYFPGA-- ---------- -----HRQVY CYP2C8 L-NS-PWIQV CNNFPL---- LIDCFPGT-- ---------- -----HNKVL CYP2C9 L-SS-PWIQI CNNFSP---- IIDYFPGT-- ---------- -----HNKLL CYP2C18 L-SS-PWIQV CNNFPA---- LIDYLPGS-- ---------- -----HNKIA CYP2C19 V-ST-PWIQI CNNFPT---- IIDYFPGT-- ---------- -----HNKLL CYP2D6 E-SG-FLREV LNAVP----V LLHIP-AL-- ---------- -----AGKVL CYP2E1h L-ST-PWLQL YNNFPS---- FLHYLPGS-- ---------- -----HRKVI CYP2F1 M-SS-PWGEL YDILDPRFPS LLDWVPGP-- ---------- -----HQRIF CYP2G2P M-ST-PWAQL YDMYS----G IMQYLPGR-- ---------- -----HNLIY CYP2J2 E-AS-KTCQL YNVFP----W IMKFLPGP-- ---------- -----HQTLF CYP2R1h A-AS-ASVFL YNAFP----W IGILPFGK-- ---------- -----HQQLF CYP2S1h V-SS-QGGQT YEMFS----W FLRPLPGP-- ---------- -----HKQLL CYP2T2P I-SS-RWGES ---------- LMDWLPGP-- ---------- -----HHRIF CYP2U1h C-LN-SQVLL VNICP----W LYYLPFGP-- ---------- -----FKELR CYP3A4 NTKKLLRFDF LDPF----FL SIIFP----- ---------- -------FLI CYP3A5 STKKFLKFGF LDPL----FL SIILFP---- ---------- -------FLT CYP3A7 NTKKLLRFNP LDPF----VL SIKVFP---- ---------- -------FLT CYP3A43 NMKKLLKLDF LDPF----LL LISLFP---- ---------- -------FLT CYP4A11 VFSRVRNAFH QNDT----IY SLT------- ---------- ---SAGRWTH CYP4A22 VFCCMRNAFH ENDT----IY SLT------- ---------- ---SAGRWTH CYP4B1h MQQRLVSFQY HNDF----IY WLTP------ ---------- ----HGRRFL CYP4F2 VSKRHHEILL HIDF----LY YLTP------ ---------- ----DGQRFR CYP4F3 VTKRHQQILL YIDF----LY YLTP------ ---------- ----DGQRFR CYP4F8 VVKRNNQFFR YKDF----LY FLTP------ ---------- ----CGRRFH CYP4F11 VEKRNQQILL HTDF----LY YLTP------ ---------- ----DGQRFR CYP4F12 VEKRSQHILQ HMDF----LY YLSH------ ---------- ----DGRRFH CYP4F22 SVRRQYRLHH YLDF----IY YRSA------ ---------- ----DGRRFR CYP4F23P SLKRHQHIFL LTDF----LY FLTP------ ---------- ----NGRRFC CYP4V2 IFRRIKMPWL WLDL----WY LMFK------ ---------- ----EGWEHK CYP4X1h IFHRLYSLLY HSDI----IF KLS------- ---------- ---PQGYRFQ CYP4Z1 SNQRMNNFLH HNDL----VF KFS------- ---------- ---SQGQIFS CYP5A1h HCKRFFEFCI PRPI----LV LLLSFP---- ---------- -------SIM CYP7A1h LNNLDNFKQF DKVFP----- ---------- ---------- -----ALVAG CYP7B1h SELRDDFLKF DDKFA----- ---------- ---------- -----YLVSN CYP8A1h ADVFHTFRQL DRLLP----- ---------- ---------- -----KLARG CYP8B1h GELFMEFRKF DLLFP----- ---------- ---------- -----RFVYS CYP11A1h --QMFHTSVP MLNLP---PD LFRLFRTK-- ---------- ----TWKDHV CYP11B1h --VMFKSTVQ LMFMP---RS LSRWTSPK-- ---------- ----VWKEHF CYP11B2h --VMFKSTVQ LMFMP---RS LSRWISPK-- ---------- ----VWKEHF CYP17h L-SKD---SL VDLVP----- WLKIFPNKT- ---------- -----LEKLK CYP19h LLIK---PDI FFKIS----W LYKKYEKS-- ---------- -----VKDLK CYP20h WSEIGKGFLD GSLD----KN MTR------- ---------- ----K-KQYE CYP21A2h W-SHWS-IQI VDVIP----- FLRFFPNPG- ---------- -----LRRLK CYP24h --TMMSTFGR MMVTP---VE LHKSLNTK-- ---------- ----VWQGHT CYP26A1h VEAFEEMTRN LFSLPI---- ---------- ---------- -----DVPFS CYP26B1h FEVYQQFVDN VFSLPV---- ---------- ---------- -----DLPFS CYP26C1h ARTFEQLVEN LFSLPL---- ---------- ---------- -----DVPFS CYP27A1h --LMFQNSLY ATFLP---KW TRPVLP---- ---------- ----FWKRYL CYP27B1h --SVFVSTLL TMAMP---HW LRHLVPG--- ---------- ----PWGRLC CYP27C1h MFSMFKTSMY AGAIP---RW LRPFIPK--- ---------- ----PWREFC CYP39A1h HQYFQVYDED FEYGS----- ---------- ---------- -----QLPEC CYP46h GITASRNTLA KFLP----GK RKQ------- ---------- ----L-REVR CYP51h ADLDGGFSHA AWLLPG---- ---------- ---------- -----WLPLP Cyp1a1 DLNDKFYSFM K--KLIKEHY RTFEK-GH-- ---------- --IRDITDSL Cyp1a2 TFNDNFVLFL Q--KTVQEHY QDFNK-NS-- ---------- --IQDITSAL Cyp1b1 QLNRNFSNFV L--DKFLRHR ESLVPGAA-- ---------- --PRDMTDAF Cyp2a4 KELQGLEDFI T--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF Cyp2a5 KELQGLEDFI T--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF Cyp2a12 KDSHKLEDFM I--QKVKQNQ STLDPN-S-- ---------- --PRDFIDSF Cyp2b9 KKQQELLDYI A--HSVEKHK ATLDPS-A-- ---------- --PRDYIDTY Cyp2b10 KNLQELLDYI G--HSVEKHR ATLDPS-V-- ---------- --PRDFIDIY Cyp2b13 KNQQEILNFI T--HRVEKHR ASLDPS-E-- ---------- --PRDFIDTY Cyp2b19 KNLQEILDYI G--HSVEKHR ATLDPS-A-- ---------- --PRDFIDTY Cyp2b23 KNIQEILNYI G--HSVEQHK ATLDPS-A-- ---------- --PRDFIDTY Cyp2c29 KNFNYLKSYL L--EKIKEHK ESLDVT-N-- ---------- --PRDFIDYY Cyp2c37 KNYACIKNFL L--EKIKEHE ESLDVT-I-- ---------- --PRDFIDYF Cyp2c38 KNFKYIRSYL L--EKVKEHQ ASLDFT-N-- ---------- --PRDFIDYF Cyp2c39 KNVKYIRSYL L--EKIKEHQ ESLDVT-N-- ---------- --PRDFIDYY Cyp2c40 KNHTWIKSYL L--GKIKEHE ESLDVT-N-- ---------- --PRDFIDYF Cyp2c44 KRLGGVKNFI L--EKVKEHQ EFLDPA-N-- ---------- --PRDYIDCF Cyp2c50 KNYACIKNFL L--EKIKEHE ESLDVT-I-- ---------- --PRDFIDYF Cyp2c54 KNYAYIKNFL L--EKIREHK ESLDVT-I-- ---------- --PRDFIDYF Cyp2c55 KNFTEIKSYI L--GRVKEHQ ETLDMD-N-- ---------- --PRDFIDCF Cyp2c65 KNFAFAEHYF L--SKVKQHQ ESLDIN-N-- ---------- --PRDFIDCF Cyp2c66 KNFDFAKHYF L--AKVIQHK ESLDIN-N-- ---------- --PRDFIDCF Cyp2c67 KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFIDYF Cyp2c68 KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFVDYF Cyp2c69 KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFIDYF Cyp2c70 KDVTQQKKFI L--EEINRHQ KSLDLS-N-- ---------- --PQDFIDYF Cyp2d9 QGQKSFIAIL D--NLLTENR TTWDPVQA-- ---------- --PRNLTDAF Cyp2d10 QGQKSLLAIV E--NLLTENR NTWDPDQP-- ---------- --PRNLTDAF Cyp2d11 QGQKSFMAIL D--NLLTENR TTWDPDQP-- ---------- --PRNLTDAF Cyp2d12 QSQKSFIAIV D--NLLTENR TTWDPAQS-- ---------- --PRNLTDAF Cyp2d13 PGQKTFLTLV N--KLVTEHK RTWDPDQP-- ---------- --PRDLTDAF Cyp2d22 PGKRAFVTML D--ELLAEHK TTWDPTQP-- ---------- --PRDLTDAF Cyp2d26 PKLNSFIALV N--KMLIEHD LTWDPAQP-- ---------- --PRDLTDAF Cyp2e1 KNVSEIRQYT L--GKAKEHL KSLDIN-C-- ---------- --PRDVTDCL Cyp2f2 RNFGGMKDLI A--RSVREHQ DSLDPN-S-- ---------- --PRDFIDCF Cyp2g1 NLIEDLKDFI A--SRVKINE ASFDPS-N-- ---------- --PRDFIDCF Cyp2j5 RNWGKLKLFV S--HIVKKHE KDWNPDE--- ---------- --PRDFIDAF Cyp2j6 RNWEKLKLFV S--CMIDDHR KDWNPDE--- ---------- --PRDFIDAF Cyp2j7 RNWERLKMIV Y--HMMESHR KDWNPDE--- ---------- --PRDFIDAF Cyp2j8 SNWEKLKLFF S---VMDSHR KDWNPSA--- ---------- --PRDFIDAF Cyp2j9 RNWRKLQLFV S--DIVNNHR RDWDPDE--- ---------- --PRDFIDAF Cyp2j13 ATWRKLKSYI A--DIIDNHR KDWNPDE--- ---------- --PRDFIDAF Cyp2j12 RNWEKLKLFI Y--QMMESHR KDWNPDE--- ---------- --PRDFIDAF cyp2j11 SNWEKLKLFV S--RMMDSHR EDWNPSA--- ---------- --PRDFIDAF Cyp2r1 RNADVVYDFL S--RLIEKAA VNRKPHL--- ---------- --PHHFVDAY Cyp2s1 HHLGTLAAFT I--QQVQKHQ GRFQTSGP-- ---------- --ARDVVDAF Cyp2t4 KNFQELRLFI S--EQIQWHW QSRQTG-E-- ---------- --PRDFIDCF Cyp2U1 QIERDISCFL K--NIIREHQ ESLDASN--- ---------- --PQDFIDMY Cyp2w1 SKIEEVRTIL R--TLLETRR PPLPTGGP-- ---------- --AQSYVEAL CYP2W1h RKIEEVRAIL R--TLLEARR PHVCPGDP-- ---------- --VCSYVDAL Cyp3a11 PVYEMLNICM FPKDSIEFFK KFVDRMKESR -LDSKQKH-- --RVDFLQLM Cyp3a13 PVFDALNVSL FPRDVISFFT TSVERMKENR -MKEKEKQ-- --RVDFLQLM Cyp3a16 PIYEMLNICM FPKDSIEFFK KFVDRMTENR -LDSKQKH-- --RVDFIYLM Cyp3a25 PIYEMLNFSI FPRDSMNFFK KFVKRMKKER -LASNQKN-- --RVDFLQLM Cyp3a57 PIYEMLNLSI FPRQSMNFFK KFVKKMKKDR -LDYNQKN-- --RVDFLQLM Cyp3a41 PVYEMLNICM FPKDSIEFFK KFVNRMKESR -LDSKQKH-- --RVDFLQLM Cyp3a44 PVYEMLNICM FPNDSIEFFK KFVDRMQESR -LDSNQKH-- --RVDFLQLM Cyp4a10 QACQLAHDHT --DGVIKLRK DQLQDEGELE KIKKKRR--- ---LDFLDIL Cyp4a12 SACKLAHDHT --DQVIKSRR IQLQDEEELE KLKKKRR--- ---LDFLDIL Cyp4a14 HACQIAHEHT --DGVIKMRK SQLQNEEELQ KARKKRH--- ---LDFLDIL Cyp4a30 HACQIAHKHT --ERVIRMRK AQLQNEAELE KFRKKKR--- ---LDFLDIL Cyp4a29 SACQIAHEHT --DRVVKLRK AQLQDNKSMK KLRGKRC--- ---LDFLDIL Cyp4b1 RACQIAHDHT --DHVIRQRK AALQDEKEQK KLQERRH--- ---LDFLDIL Cyp4f13 KACDLVHNFT --DAVIKERR STLN-TQGVE FLKAKAKT-- -KTLDFIDVL Cyp4f14 KACNVVHEFT --DAVIRERH RTLPDQGLDD FLKSKAKS-- -KTLDFIDVL Cyp4f15 KACHLVHSFT --DAVIQDRR RTLPSKHEDD VLKAKAKS-- -KTLDFIDVL Cyp4f16 KACDLVHNFT --DAVIRERR HTLSSQNHDE FLKSKTKS-- -KTLDFIDVL Cyp4f17 KACDLVHNFT --DAVIRERR RTLSSQNLDE FLKSKTKS-- -KTLDFIDVL Cyp4f18 KACRLVHDFT --DAVIRERR RTLLDQGGDD VLKAKAKA-- -KTLDFIDVL Cyp4f37 KACDLVHNFT --DAVIRERR HTLSSQNHDE FLKSKTKS-- -KTLDFIDVL Cyp4f39 QACDTVHNFT --TEVIQERR QALRQQGAEA WLKAKQG--- -KTLDFIDVL Cyp4f40 KACRLVHDFT --DAVIQERR RTLLKHGGDD IIKAKAKS-- -KTLDFIDVL Cyp4v3 RGLKCLHTFT --NNVIAERV KERKAEEDWT GAGRGPIPSK NKRKAFLDLL Cyp4x1 ELGKVIHQYT --EKIIQDRK KILKNQVKQD DTQTS----- ---QIFLDIV Cyp5a1 VPLARILPNK NRDELNGFFN TLIRNVIALR DQQAAEER-- --RRDFLQMV Cyp7a1 VPIHLLKTAH KARERLAESL KHKNLYMRDQ V--------- ----SELIRL Cyp7b1 IPIQLLRNEE SMQKKIIKCL TSEKVAQMQG Q--------- ----SKIVQE Cyp8a1 SLSAGDKDHA CSVKNRLWKL LSPARLASRA D--------- ----RSSWLE Cyp8b1 LLGPREWVEV SQLQRLFHQR LSVEQNLEKD G--------- ----ISCWLG Cyp11a1 AAWDVIFNKA D--EYTQNFY WDLRQK-R-- ---------- --DFSQYPGV Cyp11b1 ESWDFISEYG T--KCIKNVY RELAEG---- ---------- --RPQSWS-V Cyp11b2 DAWDVISEYG N--RCIWKVH QELRLG---- ---------- --SSQTYSGI Cyp17 EHTKIREKTL V--EMFEKCK EKFNSE-S-- ---------- --LSSLTDIL Cyp19 DEIAVLVEKK R--HKVSTAE KLEDC----- ---------- ---MDFATDL Cyp20 EALMQLESTL --KKIIKERK GGNFR----- ---------- -----QHTFI Cyp21 QIQESRDHIV K--QQLKRHK DSLVAG-Q-- ---------- --WKDMIDYM Cyp24 LAWDTIFKSV K--PCIDHRL ERYSQQPG-- ---------- -------ADF Cyp26a1 GLYRGVKARN LIHARIEENI RAKIRRLQAT EPDGGCK--- ----DALQLL Cyp26b1 GYRRGIQARQ ILQKGLEKAI REKLQCTQGK DYS------- ----DALDIL Cyp26c1 GLRKGIRARD QLYEHLDEAV AEKLQEKQTA EPG------- ----DALLLI Cyp27a1 NGWDNIFSFG K--KLIDEKV QELKAQLQET ---------- GPDGVRVSGY Cyp27b1 RDWDQMFAFA Q--RHVELRE GEAAMRNQGK ---------- PEEDMPSGHH Cyp39 LLRNWSKSKR WLLALFEKNI GNIKAHGSAG ---------- ----HSGTLL Cyp46 ESIRLLRQVG --KDWVQRRR EALKRGED-- ---MPA---- ----DILTQI Cyp51 SFRRRDRAHR EIKNIFYKAI QKRRLSKEPA E--------- ----DILQTL CYP1A1h DLNEKFYSFM Q--KMVKEHY KTFEK-GH-- ---------- --IRDITDSL CYP1A2h AFNQRFLWFL Q--KTVQEHY QDFDK-NS-- ---------- --VRDITGAL CYP1B1h QLNRNFSNFI L--DKFLRHC ESLRPGAA-- ---------- --PRDMMDAF CYP2A6 QLLQGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF CYP2A7 KLLLGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PQDFIDSF CYP2A13 KELQGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF CYP2B6 KNLQEINAYI G--HSVEKHR ETLDPS-A-- ---------- --PKDLIDTY CYP2C8 KNVALTRSYI R--EKVKEHQ ASLDVN-N-- ---------- --PRDFMDCF CYP2C9 KNVAFMKSYI L--EKVKEHQ ESMDMN-N-- ---------- --PQDFIDCF CYP2C18 ENFAYIKSYV L--ERIKEHQ ESLDMN-S-- ---------- --ARDFIDCF CYP2C19 KNLAFMESDI L--EKVKEHQ ESMDIN-N-- ---------- --PRDFIDCF CYP2D6 RFQKAFLTQL D--ELLTEHR MTWDPAQP-- ---------- --PRDLTEAF CYP2E1h KNVAEVKEYV S--ERVKEHH QSLDPN-C-- ---------- --PRDLTDCL CYP2F1 QNFKCLRDLI A--HSVHDHQ ASS------- ---------- --PRDFIQCF CYP2G2P YLVEELKDFI A--SRVKINE ASFDPQ-N-- ---------- --PRDFIDCF CYP2J2 SNWKKLKLFV S--HMIDKHR KDWNPAE--- ---------- --TRDFIDAY CYP2R1h RNAAVVYDFL S--RLIEKAS VNRKPQL--- ---------- --PQHFVDAY CYP2S1h HHVSTLAAFT V--RQVQQHQ GNLDASGP-- ---------- --ARDLVDAF CYP2T2P RNFSELRVIS ---EQIQRHW QMRQPA-E-- ---------- --PRDFIDCL CYP2U1h QIEKDITSFL K--KIIKDHQ ESLDREN--- ---------- --PQDFIDMY CYP3A4 PILEVLNICV FPREVTNFLR KSVKRMKESR -LEDTQKH-- --RVDFLQLM CYP3A5 PVFEALNVSL FPKDTINFLS KSVNRMKKSR -LNDKQKH-- --RLDFLQLM CYP3A7 PILEALNITV FPRKVISFLT KSVKQIKEGR -LKETQKH-- --RVDFLQLM CYP3A43 PVFEALNIGL FPKDVTHFLK NSIERMKESR -LKDKQKH-- --RVDFFQQM CYP4A11 RACQLAHQHT --DQVIQLRK AQLQKEGELE KIKRKRH--- ---LDFLDIL CYP4A22 RACQLAHQHT --DQVIQLRK AQLQKEGELE KIKRKRH--- ---LDFLDIL CYP4B1h RACQVAHDHT --DQVIRERK AALQDEKVRK KIQNRRH--- ---LDFLDIL CYP4F2 RACRLVHDFT --DAVIQERR RTLPSQGVDD FLQAKAKS-- -KTLDFIDVL CYP4F3 RACRLVHDFT --DDVIQERR RTLPSQGVDD FLQAKAKS-- -KTLDFIDVL CYP4F8 RACRLVHDFT --DAVIQERR RTLTSQGVDD FLQAKAKS-- -KTLDFIDVL CYP4F11 RACHLVHDFT --DAVIQERR RTLPTQGIDD FLKNKAKS-- -KTLDFIDVL CYP4F12 RACRLVHDFT --DAVIRERR RTLPTQGIDD FFKDKAKS-- -KTLDFIDVL CYP4F22 QACDMVHHFT --TEVIQERR RALRQQGAEA WLKAKQG--- -KTLDFIDVL CYP4F23P RACDIVHNFT --DAVIQERR RTLTSQGVDD FLQAKAKS-- -KTLDFIDVL CYP4V2 KSLQILHTFT --NSVIAERA NEMNANEDCR GDGRGSAPSK NKRRAFLDLL CYP4X1h KLSRVLNQYT --DTIIQERK KSLQAGVKQD NTPKRKY--- ---QDFLDIV CYP4Z1 KFNQELHQFT HLEKVIQDRK ESLKDKLKQD TTQKRR---- ---WDFLDIL CYP5A1h VPLARILPNK NRDELNGFFN KLIRNVIALR DQQAAEER-- --RRDFLQMV CYP7A1h LPIHMFRTAH NAREKLAESL RHENLQKRES I--------- ----SELISL CYP7B1h IPIELLGNVK SIREKIIKCF SSEKLAKMQG W--------- ----SEVFQS CYP8A1h SLSVGDKDHM CSVKSRLWKL LSPARLARRA H--------- ----RSKWLE CYP8B1h LLWPREWLEV GRLQHLFHKM LSVSHSQEKE G--------- ----ISNWLG CYP11A1h AAWDVIFSKA D--IYTQNFY WELRQKGS-- ---------- --VHHDYRGM CYP11B1h EAWDCIFQYG D--NCIQKIY QELAFS---- ---------- --RPQQYTSI CYP11B2h EAWDCIFQYG D--NCIQKIY QELAFN---- ---------- --RPQHYTGI CYP17h SHVKIRNDLL N--KILENYK EKFRSD-S-- ---------- --ITNMLDTL CYP19h DAIEVLIAEK R--CRISTEE KLEEC----- ---------- ---MDFATEL CYP20h DALMQLESVL --RNIIKERK GRNFS----- ---------- -----QHIFI CYP21A2h QAIEKRDHIV E--MQLRQHK ESLVAG-Q-- ---------- --WRDMMDYM CYP24h LAWDTIFKSV K--ACIDNRL EKYSQQPS-- ---------- -------ADF CYP26A1h GLYRGMKARN LIHARIEQNI RAKICGLRAS EAGQGCK--- ----DALQLL CYP26B1h GYRRGIQARQ ILQKGLEKAI REKLQCTQGK DYL------- ----DALDLL CYP26C1h GLRKGIRARD QLHRHLEGAI SEKLHEDKAA EPG------- ----DALDLI CYP27A1h DGWNAIFSFG K--KLIDEKL EDMEAQLQAA ---------- GPDGIQVSGY CYP27B1h RDWDQMFAFA Q--RHVERRE AEAAMRNGGQ ---------- PEKDLESGAH CYP27C1h RSWDGLFKFS Q--IHVDNKL RDIQYQMD-- ---------- RGR-RVSGGL CYP39A1h LLRNWSKSKK WFLELFEKNI PDIKACKSAK D--------- ----NSMTLL CYP46h ESIRFLRQVG --RDWVQRRR EALKRGEE-- ---VPA---- ----DILTQI CYP51h SFRRRDRAHR EIKDIFYKAI QKRRQSQEKI D--------- ----DILQTL Cyp1a1 IEHCQDRKL- ---------- ---------- ------DENA NVQLSDDKVI Cyp1a2 FKHSEN---- ---------- ---------- ------YKDN GGLIPEEKIV Cyp1b1 ILSAEKKASG ---------- ---------- -----APGDD SSGLDLEDVP Cyp2a4 LIRMLEEK-- ---------- ---------- ------KNPN TE-FYMKNLV Cyp2a5 LIRMLEEK-- ---------- ---------- ------KNPN TE-FYMKNLV Cyp2a12 LIHMQKE--- ---------- ---------- ------KYVN SE-FHMKNLV Cyp2b9 LLRMEKEK-- ---------- ---------- ------SNHN TE-FHHQNLM Cyp2b10 LLRMEKEK-- ---------- ---------- ------SNQH TE-FHHQNLM Cyp2b13 LLRMEKEK-- ---------- ---------- ------SNHN TE-FHHQNLM Cyp2b19 LLRMEKEK-- ---------- ---------- ------SNHH TE-FHHQNLV Cyp2b23 LLRMEKEK-- ---------- ---------- ------SNHH TE-FHHQNLL Cyp2c29 LIKQKQVN-- ---------- ---------- ------HIEQ SE-FSLENLA Cyp2c37 LINGGQED-- ---------- ---------- ------GNQP LQ-NRLEHLA Cyp2c38 LIKQKQAN-- ---------- ---------- ------HIEQ AE-YSLENLV Cyp2c39 LIKQKQAN-- ---------- ---------- ------HIQQ AE-FSLENLA Cyp2c40 LIQRRQKN-- ---------- ---------- ------GIEH MD-YTIEHLA Cyp2c44 LSKIEEEK-- ---------- ---------- ------HSLK SD-FNLENLA Cyp2c50 LINGGQED-- ---------- ---------- ------GNYP LK-NRLEHLA Cyp2c54 LIKGAQED-- ---------- ---------- ------DNHP LK-NNFEHLA Cyp2c55 LIKMEQEK-- ---------- ---------- ------HNPH SE-FTIESLM Cyp2c65 LIKMEQEK-- ---------- ---------- ------HNPK TE-FTCENLV Cyp2c66 LIKMEQEK-- ---------- ---------- ------HNPK TE-FTCENLI Cyp2c67 LIQRCQKK-- ---------- ---------- ------GIEH ME-YTIEHLA Cyp2c68 LIQRRQKN-- ---------- ---------- ------GIEH MD-YTIEHLA Cyp2c69 LIQRRQKN-- ---------- ---------- ------GIEH ME-YTIEHLA Cyp2c70 LIKMEKEK-- ---------- ---------- ------HNQK SE-FTMDNLV Cyp2d9 LAQIEKAK-- ---------- ---------- ------GNPE SS-FNDENLL Cyp2d10 LAEIEKVK-- ---------- ---------- ------GNAE SS-FNDENLR Cyp2d11 LAEIEKAK-- ---------- ---------- ------GNAE SS-FNDENLR Cyp2d12 LAEIEKAK-- ---------- ---------- ------GNPE SS-FNDENLR Cyp2d13 LAEMEKAK-- ---------- ---------- ------GNPK SS-FNEANLR Cyp2d22 LAEVEKAK-- ---------- ---------- ------GNPE SS-FNDENLR Cyp2d26 LAEVEKAK-- ---------- ---------- ------GNPE SS-FNDKNLR Cyp2e1 LIEMEKEK-- ---------- ---------- ------HSQE PM-YTMENIS Cyp2f2 LTKMAQEK-- ---------- ---------- ------QDPL SH-FNMDTLL Cyp2g1 LIKMHQDK-- ---------- ---------- ------SDPH TE-FNLKNLV Cyp2j5 LIEMQKDP-- ---------- ---------- ------DRTT S--FNEENLI Cyp2j6 LKEMTKYP-- ---------- ---------- ------EKTT S--FNEENLI Cyp2j7 LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI Cyp2j8 LTEMAKYS-- ---------- ---------- ------DKTT TS-FNEENLI Cyp2j9 LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI Cyp2j13 LNEMAKYP-- ---------- ---------- ------GKTT TS-FNEENLI Cyp2j12 LTEMSKYG-- ---------- ---------- ------DKTT TS-FNEENLI cyp2j11 LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI Cyp2r1 LDEMDQGQ-- ---------- ---------- ------NDPL ST-FSKENLI Cyp2s1 LLKMAQEK-- ---------- ---------- ------QDPG TE-FTEKNLL Cyp2t4 LDQMDKEQ-- ---------- ---------- ------QDLE SH-FQDETLV Cyp2U1 LLHMEEEQ-- ---------- ---------- ------GASR RSSFDEDYLF Cyp2w1 LQQGQEDD-- ---------- ---------- --------PE DM-FGEANVL CYP2W1h IQQGQGDD-- ---------- ---------- --------PE GL-FAEANAV Cyp3a11 MNSHNNS--- ---------- ---------- -----KDKVS HKALSDMEIT Cyp3a13 INSQN-Y--- ---------- ---------- -----KTKES HKALSDVEIV Cyp3a16 MEAYNKS--- ---------- ---------- -----KDKDS HKALSEIEIT Cyp3a25 MNTQN-S--- ---------- ---------- -----KGQES QKALSDLEMA Cyp3a57 MNTQN-S--- ---------- ---------- -----KGQES LKALSDLEMA Cyp3a41 MNAHNNS--- ---------- ---------- -----KDKDS HKALSDMEIT Cyp3a44 MNSHNNS--- ---------- ---------- -----KDKDS HKAFSNMEIT Cyp4a10 LFARME---- ---------- ---------- ---------N GDSMSDKDLR Cyp4a12 LFARME---- ---------- ---------- ---------N GKSLSDKDLR Cyp4a14 LFARME---- ---------- ---------- ---------D RNSLSDEDLR Cyp4a30 LFAQTE---- ---------- ---------- ---------D GKSLSDEDVR Cyp4a29 LLSRVSS--- ---------- ---------- --------DD GSSLSDKALR Cyp4b1 LGARDE---- ---------- ---------- ---------S GIKLSDADLR Cyp4f13 LMAEDE---- ---------- ---------- ---------H GKGLSNEDIR Cyp4f14 LLSKDE---- ---------- ---------- ---------D GKELSDEDIR Cyp4f15 LLSKDE---- ---------- ---------- ---------D GKELSDEDIR Cyp4f16 LLAKDE---- ---------- ---------- ---------H GKELSDEDIR Cyp4f17 LLAKDE---- ---------- ---------- ---------H GKELSDEDIR Cyp4f18 LLSKDE---- ---------- ---------- ---------H GKALSDEDIR Cyp4f37 LLAKDE---- ---------- ---------- ---------H GKELSDEDIR Cyp4f39 LLAKDE---- ---------- ---------- ---------E GKELSDEDIR Cyp4f40 LLTKDE---- ---------- ---------- ---------D GKELSDEDIR Cyp4v3 LSVTDE---- ---------- ---------- ---------E GNRLSQEDIR Cyp4x1 LSAQGK---- ---------- ---------- --------ED ERAFSDADLR Cyp5a1 LDAQHSMNSV GVEGFDMVPE SLSSSECTKE PPQRCHPTST SKPFTVDEIV Cyp7a1 RMFLND---- ---------- ---------- ---------T LSTFDDMEKA Cyp7b1 SQDLLK---- ---------- ---------- ---------R YYRHDDSEIG Cyp8a1 SYLRHL---- ---------- ---------- ---------E EMGVSEEMQA Cyp8b1 YMLQFL---- ---------- ---------- ---------R EQGIASSMQD Cyp11a1 LYSLLGGNK- ---------- ---------- ---------- ---LPFKNIQ Cyp11b1 TAELVAERT- ---------- ---------- ---------- ---LSMDAIQ Cyp11b2 VAELISQGS- ---------- ---------- ---------- ---LPLDAIK Cyp17 IQAKMNAENN NT-------- ---------- -----GEGQD PSVFSDKHIL Cyp19 IFAERRGD-- ---------- ---------- ---------- ---LTKENVN Cyp20 DSLTQG---- ---------- ---------- ---------- --KLNEQQIL Cyp21 LQGVEK-QRD ---------- ---------- -----G--KD EERLHEGHVH Cyp24 LCDIYQQDH- ---------- ---------- ---------- ---LSKKELY Cyp26a1 IEHSWE---- ---------- ---------- ---------R GERLDMQALK Cyp26b1 IESSKE---- ---------- ---------- ---------H GKEMTMQELK Cyp26c1 INSARE---- ---------- ---------- ---------L GHEPSVQELK Cyp27a1 LHFLLTNEL- ---------- ---------- ---------- ---LSTQETI Cyp27b1 LTHFLFREK- ---------- ---------- ---------- ---VSVQSIV Cyp39 QAILEV---- ---------- ---------- ---------V ETETR-QYSP Cyp46 LKAEEG---- ---------- ---------- ---------- --AQDDEVLL Cyp51 LDSTYK---- ---------- ---------- ---------D GRPLTDEEIS CYP1A1h IEHCQEKQL- ---------- ---------- ------DENA NVQLSDEKII CYP1A2h FKHSKKG--- ---------- ---------- ------PRAS GNLIPQEKIV CYP1B1h ILSAEKKAAG ---------- ---------- -----DSHGG GARLDLENVP CYP2A6 LIRMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLV CYP2A7 LIHMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLM CYP2A13 LIRMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLV CYP2B6 LLHMEKEK-- ---------- ---------- ------SNAH SE-FSHQNLN CYP2C8 LIKMEQEK-- ---------- ---------- ------DNQK SE-FNIENLV CYP2C9 LMKMEKEK-- ---------- ---------- ------HNQP SE-FTIESLE CYP2C18 LIKMEQEK-- ---------- ---------- ------HNQQ SE-FTVESLI CYP2C19 LIKMEKEK-- ---------- ---------- ------QNQQ SE-FTIENLV CYP2D6 LAEMEKAK-- ---------- ---------- ------GNPE SS-FNDENLR CYP2E1h LVEMEKEK-- ---------- ---------- ------HSAE RL-YTMDGIT CYP2F1 LTKMAEEK-- ---------- ---------- ------EDPL SH-FHMDTLL CYP2G2P LIKMHQDK-- ---------- ---------- ------NNPR TE-FNLKNLV CYP2J2 LKEMSKHT-- ---------- ---------- ------GNPT SS-FHEENLI CYP2R1h LDEMDQGK-- ---------- ---------- ------NDPS ST-FSKENLI CYP2S1h LLKMAQEE-- ---------- ---------- ------QNPG TE-FTNKNML CYP2T2P TRWVRHGQ-- ---------- ---------- ------QDPE SH-FQETSVM CYP2U1h LLHMEEER-- ---------- ---------- ------KNNS NSSFDEEYLF CYP3A4 IDSQN-S--- ---------- ---------- -----KETES HKALSDLELV CYP3A5 IDSQN-S--- ---------- ---------- -----KETES HKALSDLELA CYP3A7 IDSQN-S--- ---------- ---------- -----KDSET HKALSDLELM CYP3A43 IDSQN-S--- ---------- ---------- -----KETKS HKALSDLELV CYP4A11 LLAKME---- ---------- ---------- ---------N GSILSDKDLR CYP4A22 LLAKME---- ---------- ---------- ---------N GSILSDKDLR CYP4B1h LGARDE---- ---------- ---------- ---------D DIKLSDADLR CYP4F2 LLSKDE---- ---------- ---------- ---------D GKKLSDEDIR CYP4F3 LLSKDE---- ---------- ---------- ---------D GKKLSDEDIR CYP4F8 LLSEDK---- ---------- ---------- ---------N GKELSDEDIR CYP4F11 LLSKDE---- ---------- ---------- ---------D GKELSDEDIR CYP4F12 LLSKDE---- ---------- ---------- ---------D GKALSDEDIR CYP4F22 LLARDE---- ---------- ---------- ---------D GKELSDEDIR CYP4F23P LLAKDE---- ---------- ---------- ---------N GKKLSDENIR CYP4V2 LSVTDD---- ---------- ---------- ---------E GNRLSHEDIR CYP4X1h LSAKD----- ---------- ---------- --------ES GSSFSDIDVH CYP4Z1 LSAKV----- ---------- ---------- --------EN TKDFSEADLQ CYP5A1h LDARHSASPM GVQDFDIVRD VFSSTGCKPN PSRQHQPSPM ARPLTVDEIV CYP7A1h RMFLND---- ---------- ---------- ---------T LSTFDDLEKA CYP7B1h RQDVLE---- ---------- ---------- ---------K YYVHEDLEIG CYP8A1h SYLLHL---- ---------- ---------- ---------E EMGVSEEMQA CYP8B1h NMLQFL---- ---------- ---------- ---------R EQGVPSAMQD CYP11A1h LYRLLGDSK- ---------- ---------- ---------- ---MSFEDIK CYP11B1h VAELLLNAE- ---------- ---------- ---------- ---LSPDAIK CYP11B2h VAELLLKAE- ---------- ---------- ---------- ---LSLEAIK CYP17h MQAKMNSDNG NA-------- ---------- -----GPDQD SELLSDNHIL CYP19h ILAEKRGD-- ---------- ---------- ---------- ---LTRENVN CYP20h DSLVQG---- ---------- ---------- ---------- --NLNDQQIL CYP21A2h LQGVAQ-PSM ---------- ---------- -----E--EG SGQLLEGHVH CYP24h LCDIYHQNR- ---------- ---------- ---------- ---LSKKELY CYP26A1h IEHSWE---- ---------- ---------- ---------R GERLDMQALK CYP26B1h IESSKE---- ---------- ---------- ---------H GKEMTMQELK CYP26C1h IHSARE---- ---------- ---------- ---------L GHEPSMQELK CYP27A1h LHFLLASGQ- ---------- ---------- ---------- ---LSPREAM CYP27B1h LTHFLFREE- ---------- ---------- ---------- ---LPAQSIL CYP27C1h LTYLFLSQA- ---------- ---------- ---------- ---LTLQEIY CYP39A1h QATLDI---- ---------- ---------- ---------V ETETSKENSP CYP46h LKAEEG---- ---------- ---------- ---------- --AQDDEGLL CYP51h LDATYK---- ---------- ---------- ---------D GRPLTDDEVA Cyp1a1 TIVLDLFGAG FDTVTTAISW SLMYLVTNPR VQRKIQEELD TVIG--RDR- Cyp1a2 NIVNDIFGAG FDTVTTAITW SILLLVTWPN VQRKIHEELD TVVG--RDR- Cyp1b1 ATITDIFGAS QDTLSTALLW LLILFTRYPD VQARVQAELD QVVG--RDR- Cyp2a4 LTTQNLFFAG TETGSTTLRY GFLLLMKYPD IEAKVHEEID RVIG--RNR- Cyp2a5 LTTLNLFFAG TETVSTTLRY GFLLLMKHPD IEAKVHEEID RVIG--RNR- Cyp2a12 MTSLNLFFAG SETVSSTLRY GFLLLMKHPD VEAKVHEEID RVIG--RNR- Cyp2b9 MSVLSLFFAG TETTSATLHY GVLLMLKYPH VTEKVQKEID QVIG--SHR- Cyp2b10 MSVLSLFFAG TETSSTTLRY GFLLMLKYPH VAEKVQKEID QVIG--SHR- Cyp2b13 MSVLSLFFAG TETTSTTLCC GFLLMLMYPH VAGKVQKEID QVIG--SHR- Cyp2b19 ISVLSLFFAG TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIG--SHR- Cyp2b23 ISVLSLFFAG TETTSTTLRY GFLLMLKYPH VAEKVQKEID QVIS--AHH- Cyp2c29 STINDLFGAG TETTSTTLRY ALLLLLKYPD VTAKVQEEID RVVG--RHR- Cyp2c37 ITVTDLFSAG TETTSTTLRY ALLLLLKYPH VTAKVQKEIE HVIG--KHR- Cyp2c38 CTINNLFAAG TETTSTTLRY ALLLLMKYPD VTAKVQEEID HVVG--RHR- Cyp2c39 CTINNLFAAG TETTSTTLRY ALLLLMKYPD VTAKVQEEID HVIG--RHR- Cyp2c40 TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- Cyp2c44 ICGSNLFTAG TETTSTTLRF GLLLLVKHPE VQAKVHEELD RVIG--RHQ- Cyp2c50 ITVTDLFSAG TETTSTTLRY ALLLLLKYPH VTAKVQEEIE HVIG--KHR- Cyp2c54 ITVTDLFIGG TESMSTTLRY ALLLLLKYPH VTAKVQEEIE HVIG--KHR- Cyp2c55 ATVTDIFVAG TETTNITLRY GLLLLLKHTE VTAKVQAEID HVIG--RHR- Cyp2c65 FTASDLFAAG TETTSTTLRY SLLLLLKYPE VTAKVQEEID CVIG--RHR- Cyp2c66 FTASDLFAAG TETTSTTLRY SLLLLLKYPE VTAKVQAEID CVIG--RHR- Cyp2c67 TLVTDLVFGG TESLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- Cyp2c68 TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- Cyp2c69 TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- Cyp2c70 VSIGDLFGAG TETTSSTVKY GLLLLLKYPE VTAKIQEEIA HVIG--RHR- Cyp2d9 MVVRDLFGAG MLTTSTTLSW ALMLMILHPD VQRRVQQEID EVIG--QVR- Cyp2d10 MVVLDLFTAG MVTTSTTLSW ALLLMILHPD VQRRVQQEID AVIG--QVR- Cyp2d11 MVVLDLFTAG MVTTSTTLSW ALLLMILHPD VQRRVQQEID AVIG--QVQ- Cyp2d12 MVVIDLFTAG ILTTSTTLSW ALLLMILHPD VQRRVQQEID EVIG--QVR- Cyp2d13 LVVFDLFGAG IVTSSITLTW ALLLMILHPD VQRRVQEEID EVIG--QVR- Cyp2d22 TVVGDLFSAG MVTTSTTLSW ALMLMILHPD VQRRVQQEID EVIG--QVQ- Cyp2d26 IVVIDLFMAG MVTTSTTLSW ALLLMILHPD VQRRVHQEID EVIG--HVR- Cyp2e1 VTLADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIG--PSR- Cyp2f2 MTTHNLLFGG TETVGTTLRH AFLILMKYPK VQARVQEEID RVVG--RSR- Cyp2g1 LTTLNLFFAG TETVSSTLRY GFLLLLKYPE VEAKIHEEIN QVIG--THR- Cyp2j5 STTLDLFLGG TETTSSTLRW ALLYMSSYPE IQENVQAEID RVIG--HKR- Cyp2j6 CSTLDLFFAG TETTSTTLRW ALLYMALYPE VQEKVQAEID RVIG--QKR- Cyp2j7 CSCLDLFIAG TETSSTALRW ALLYMTLNPE VQERVHSEID GVIG--QWR- Cyp2j8 CTTLDLFFAG TETTSTALRW ALLYITVNPE VQEKVHSEID RVIG--QGR- Cyp2j9 CSTLDLFFAG TETTSTTLRW ALLCMALYPE VQEKMQAEID RVIG--QAR- Cyp2j13 CSTLDLFLAG TETTSSTLRW ALLYMALYPE VQENVQAEID RVIG--QSK- Cyp2j12 NSTLDLFFAG SETTTNTLRW ALLYITTNPE VQEKVHSEID RVIG--HGR- cyp2j11 CTALDLFFAG TETTSNTLRW ALLYITVNPE VQEKVHSEID RVIG--HGR- Cyp2r1 FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVHKEID LIVG--HNR- Cyp2s1 MTVTYLLFAG TMTIGATIRY ALLLLLRYPQ VQQRVREELI QELG--PGR- Cyp2t4 MTTHDLFFGG TETTSTTLRY GLLIMLKYPE VAAKVQEELD ATVG--RTW- Cyp2U1 YIIGDLFIAG TDTTTNSLLW CLLYMSLNPD VQKKVHEEIE RVIG--CDR- Cyp2w1 ACTLDMVMAG TETTAATLQW AVFLMVKHPH VQGRVQEELD RVLG--PGQ- CYP2W1h ACTLDMVMAG TETTSATLQW AALLMGRHPD VQGRVQEELD RVLG--PGR- Cyp3a11 AQSIIFIFAG YETTSSTLSF TLHSLATHPD IQKKLQDEID EALP---NKA Cyp3a13 AQSVIFIFAG YETTSSALSF ALYLLAIHPD VQKKLQDEID AALP---NKA Cyp3a16 AQSIIFIFAG YETTSSILSF TVYSLATHPD IQKKLQEEID EALP---NKA Cyp3a25 AQAVIFIFGG YDATSTSISL IMYELATHPD VQKKLQDEID RTLP---NKA Cyp3a57 AQTLIFIFGG YDGTSTSISF IMYELATHPD VQKKLQDEID RALP---NKA Cyp3a41 AQSIVFIFAG YETTSSTLSF TLYCLATHPD IQKKLQEEID ETLP---NKA Cyp3a44 VQSIIFISAG YETTSSTLSF TLYCLATHPD IQKKLQAEID KALP---NKA Cyp4a10 AEVDTFMFEG HDTTASGVSW IFYALATHPD HQQRCREEVQ SLLG---DGS Cyp4a12 AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ SLLG---DGT Cyp4a14 AEVDTFMFEG HDTTASGISW IFYALATHPE HQQRCREEVQ SILG---DGT Cyp4a30 AEMDTFMFEG HNTTASGISW IFYALATHPE HQQRCREEVK SILG---NGT Cyp4a29 AEVDSLMFGG HDTPASGISW VFYALATHPD HQQRCREEVQ SLLG---DGS Cyp4b1 AEVDTFMFEG HDTTTSGISW FLYCMALYPM HQQRCREEVR EILG---DRD Cyp4f13 AEADTFMFGG HDTTTSALSW ILYNLARHPE YQERCRQEVQ ELLR---DRD Cyp4f14 AEADTFMFEG HDTTASGLSW ILYNLARHPE YQERCRQEVQ ELLR---GRE Cyp4f15 AEADTFMFEG HDTTASGLSW ILYNLARHPE YQERCRQEVQ ELLR---DRE Cyp4f16 AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---DRE Cyp4f17 AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---GRE Cyp4f18 AEADTFMFGG HDTTASGLSW ILYNLARHPE YQERCRQEVR ELLR---DRE Cyp4f37 AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---GRE Cyp4f39 AEADTFMFEG HDTTSSGLSW ALFNLAKYPE YQEKCREEIQ EVMK---GRE Cyp4f40 AEADTFMFRG HDTTASGLSW ILYNLARHPE HQERCRQEVQ ELLR---DRD Cyp4v3 EEVDTFMFEG HDTTAAAINW SLYLLGTNPE VQRKVDQELD EVFG---RSH Cyp4x1 AEVNTFMWAG HDASAASISW LLYCLALNPE HQDRCRTEIR SILG---DGS Cyp5a1 GQAFLFLIAG HEVITNTLSF ITYLLATHPD CQERLLKEVD LFMG---KHP Cyp7a1 KTHLVILWAS QANTIPATFW SLFQMIRSPE AMKAASEEVN GSLQSAGQEL Cyp7b1 AHHLGFLWAS LANTIPAMFW AMYYILRHPE AMEALRDEID SFLQSTGQKK Cyp8a1 RALVLQLWAT QGNMGPTAFW LLLFLLKNPE ALAAVRAELK HTVWQAEQPV Cyp8b1 KFNFMMLWAS QGNTGPTCFW VLLFLLKHQD AMKAVREEAT RVMGKARLEA Cyp11a1 ANITEMLAGG VDTTSMTLQW NLYEMAHNLK VQEMLRAEVL AARR--QAQ- Cyp11b1 ANSMELIAGS TDTTSTPLVM TFFELARNPD VQQALRQESL AAEA--SIA- Cyp11b2 ANSMELTAGS VDTTAIPLVM TLFELARNPD VQKALRQESL AAEA--SIA- Cyp17 VTVGDIFGAG IETTSSVLNW ILAFLVHNPE VKRKIQKEID QYVG--FSR- Cyp19 QCILEMLIAA PDTMSVTLYF MLLLVAEYPE VEAAILKEIH TVVG---DR- Cyp20 EDCVVFSLAS CIITARLCTW TIHFLTTTGE VQKKLCKEID QVLG---EG- Cyp21 MSVVDLFIGG TETTATTLSW AVAFLLHHPE IQKRLQEELD LKLG--PGS- Cyp24 AAVTELQLAA VETTANSLMW ILYNLSRNPQ VQQRLLREIQ SVLP--DNQ- Cyp26a1 QSSTELLFGG HETTASAATS LITYLGLYPH VLQKVREEIK SKGLLCKSNQ Cyp26b1 DGTLELIFAA YATTASASTS LIMQLLKHPA VLEKLREELR AQGLLHGGGC Cyp26c1 ELAVELLFAA FFTTASASTS LILLLLQHPA AITKIQQELS AQGLGRACTC Cyp27a1 GTFPELLLAG VDTTSNTLTW ALYHLSKSPE IQEALHKEVT GVVP--FGK- Cyp27b1 GNVTELLLAG VDTVSNTLSW TLYELSRHPD VQTALHSEIT AGTR-GSCA- Cyp39 NYGLVVLWAA LANAPPIAFW TLGYILSHPD IHRTVLESIS SVFGTAGKDK Cyp46 DNFVTFFIAG HETSANHLAF TVMELSRQPE IVARLQAEVD EVVG---SKR Cyp51 GMLIGLLLAG QHTSSTTSAW MGFFLAKDKP LQEKCYLEQK AVCGEDLPP- CYP1A1h NIVLDLFGAG FDTVTTAISW SLMYLVMNPR VQRKIQEELD TVIG--RSR- CYP1A2h NLVNDIFGAG FDTVTTAISW SLMYLVTKPE IQRKIQKELD TVIG--RER- CYP1B1h ATITDIFGAS QDTLSTALQW LLLLFTRYPD VQTRVQAELD QVVG--RDR- CYP2A6 MTTLNLFIGG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- CYP2A7 MSTLNLFIAG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- CYP2A13 MTTLNLFFAG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- CYP2B6 LNTLSLFFAG TETTSTTLRY GFLLMLKYPH VAERVYREIE QVIG--PHR- CYP2C8 GTVADLFVAG TETTSTTLRY GLLLLLKHPE VTAKVQEEID HVIG--RHR- CYP2C9 NTAVDLFGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVIG--RNR- CYP2C18 ATVTDMFGAG TETTSTTLRY GLLLLLKYPE VTAKVQEEIE CVVG--RNR- CYP2C19 ITAADLLGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVIG--RNR- CYP2D6 IVVADLFSAG MVTTSTTLAW GLLLMILHPD VQRRVQQEID DVIG--QVR- CYP2E1h VTVADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIG--PSR- CYP2F1 MTTHNLLFGG TKTVSTTLHH AFLALMKYPK VQARVQEEID LVVG--RAR- CYP2G2P LTTLNLFFAG TETVSSTLRY GFLLLMKHPE VEAKIHEEIN QVIG--PHR- CYP2J2 CSTLDLFFAG TETTSTTLRW ALLYMALYPE IQEKVQVEID RVIG--QGQ- CYP2R1h FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVQKEID LIMG--PNG- CYP2S1h MTVIYLLFAG TMTVSTTVGY TLLLLMKYPH VQKWVREELN RELG--AGQ- CYP2T2P TT--HFFFGV TETTSTTLCY GLLILLKYLE VAAKVQELDP VVG---WRP- CYP2U1h YIIGDLFIAG TDTTTNSLLW CLLYMSLNPD VQEKVHEEIE RVIG--ANR- CYP3A4 AQSIIFIFAG YETTSSVLSF IMYELATHPD VQQKLQEEID AVLP---NKA CYP3A5 AQSIIFIFAG YETTSSVLSF TLYELATHPD VQQKLQKEID AVLP---NKA CYP3A7 AQSIIFIFAG YETTSSVLSF IIYELATHPD VQQKVQKEID TVLP---NKA CYP3A43 AQSIIIIFAA YDTTSTTLPF IMYELATHPD VQQKLQEEID AVLP---NKA CYP4A11 AEVDTFMFEG HDTTASGISW ILYALATHPK HQERCREEIH SLLG---DGA CYP4A22 AEVDTFMFEG HDTTASGISW ILYALATHPK HQERCREEIH GLLG---DGA CYP4B1h AEVDTFMFEG HDTTTSGISW FLYCMALYPE HQHRCREEVR EILG---DQD CYP4F2 AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQERCRQEVQ ELLK---DRE CYP4F3 AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQERCRQEVQ ELLK---DRE CYP4F8 AEADTFMFGG HDTTASGLSW VLYNLARHPE YQERCRQEVQ ELLK---DRE CYP4F11 AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQEQCRQEVQ ELLK---DRE CYP4F12 AEADTFMFGG HDTTASGLSW VLYNLARHPE YQERCRQEVQ ELLK---DRD CYP4F22 AEADTFMFEG HDTTSSGISW MLFNLAKYPE YQEKCREEIQ EVMK---GRE CYP4F23P AEADTFMSGG HDTTASGLSW VLYNLARYPE YQEHCRQEVQ ELLK---NGD CYP4V2 EEVDTFMFEG HDTTAAAINW SLYLLGSNPE VQKKVDHELD DVK-----SD CYP4X1h SEVSTFLLAG HDTLAASISW ILYCLALNPE HQERCREEVR GILG---DGS CYP4Z1 AEVKTFMFAG HDTTSSAISW ILYCLAKYPE HQQRCRDEIR ELLG---DGS CYP5A1h GQAFIFLIAG YEIITNTLSF ATYLLATNPD CQEKLLREVD VFKE---KHM CYP7A1h KTHLVVLWAS QANTIPATFW SLFQMIRNPE AMKAATEEVK RTLENAGQKV CYP7B1h AHHLGFLWAS VANTIPTMFW AMYYLLRHPE AMAAVRDEID RLLQSTGQKK CYP8A1h RALVLQLWAT QGNMGPAAFW LLLFLLKNPE ALAAVRGELE SILWQAEQPV CYP8B1h KFNFMMLWAS QGNTGPTSFW ALLYLLKHPE AIRAVREEAT QVLGEARLET CYP11A1h ANVTEMLAGG VDTTSMTLQW HLYEMARNLK VQDMLRAEVL AARH--QAQ- CYP11B1h ANSMELTAGS VDTTVFPLLM TLFELARNPN VQQALRQESL AAAA--SIS- CYP11B2h ANSMELTAGS VDTTAFPLLM TLFELARNPD VQQILRQESL AAAA--SIS- CYP17h TTIGDIFGAG VETTTSVVKW TLAFLLHNPQ VKKKLYEEID QNVG--FSR- CYP19h QCILEMLIAA PDTMSVSLFF MLFLIAKHPN VEEAIIKEIQ TVIG---ER- CYP20h EDSMIFSLAS CIITAKLCTW AICFLTTSEE VQKKLYEEIN QVFG---NG- CYP21A2h MAAVDLLIGG TETTANTLSW AVVFLLHHPE IQQRLQEELD HELG--PGAS CYP24h AAVTELQLAA VETTANSLMW ILYNLSRNPQ VQQKLLKEIQ SVLP--ENQ- CYP26A1h QSSTELLFGG HETTASAATS LITYLGLYPH VLQKVREELK SKGLLCKSNQ CYP26B1h DGTLELIFAA YATTASASTS LIMQLLKHPT VLEKLRDELR AHGILHSGGC CYP26C1h ESAVELLFAA FFTTASASTS LVLLLLQHPA AIAKIREELV AQGLGRACGC CYP27A1h GSLPELLMAG VDTTSNTLTW ALYHLSKDPE IQEALHEEVV GVVP--AGQ- CYP27B1h GNVTELLLAG VDTVSNTLSW ALYELSRHPE VQTALHSEIT AALSPGSSA- CYP27C1h ANVTEMLLAG VDTTSFTLSW TVYLLARHPE VQQTVYREIV KNLG--ERH- CYP39A1h NYGLLLLWAS LSNAVPVAFW TLAYVLSHPD IHKAIMEGIS SVFGKAGKDK CYP46h DNFVTFFIAG HETSANHLAF TVMELSRQPE IVARLQAEVD EVIG---SKR CYP51h GMLIGLLLAG QHTSSTTSAW MGFFLARDKT LQKKCYLEQK TVCGENLPP- Cyp1a1 ---------- --------QP RLS------- DRPQLPYLEA FILETFRHS- Cyp1a2 ---------- --------QP RLS------- DRPQLPYLEA FILEIYRYT- Cyp1b1 ---------- --------LP CMS------- DQPNLPYVMA FLYESMRFS- Cyp2a4 ---------- --------QP KYE------- DRMKMPYTEA VIHEIQRFA- Cyp2a5 ---------- --------QP KYE------- DRMKMPYTEA VIHEIQRFA- Cyp2a12 ---------- --------QP QYE------- DHMKMPYTQA VINEIQRFS- Cyp2b9 ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- Cyp2b10 ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- Cyp2b13 ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- Cyp2b19 ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFT- Cyp2b23 ---------- --------VP TLE------- DRIKMPYTEA VIHEIQRFS- Cyp2c29 ---------- --------SP CMQ------- DRSHMPYTDA MIHEVQRFI- Cyp2c37 ---------- --------SP CMQ------- DRSRMPYTDA MIHEVQRFI- Cyp2c38 ---------- --------SP CMQ------- DRSHMPYTDA MIHEVQRFI- Cyp2c39 ---------- --------SP CMQ------- DRNHMPYTDA MIHEVQRFI- Cyp2c40 ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYI- Cyp2c44 ---------- --------PP SMK------- DKMKLPYTDA VLHEIQRYI- Cyp2c50 ---------- --------SP CMQ------- DRSRMPYTDA MIHEVQRFI- Cyp2c54 ---------- --------RP CMQ------- DRSHMPYTNA MIHEVQRFI- Cyp2c55 ---------- --------SP CMQ------- DRTRMPYTDA MVHEIQRYI- Cyp2c65 ---------- --------SP CMQ------- DRHSMPYTDA VLHEIQRYI- Cyp2c66 ---------- --------SP CMQ------- DRHSMPYTDA VLHEIQRYI- Cyp2c67 ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYV- Cyp2c68 ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYI- Cyp2c69 ---------- --------SP CMQ------- DRKHMPYTNA MVHEVQRYV- Cyp2c70 ---------- --------RP TMQ------- DRNHMPYTDA VLHEIQRYI- Cyp2d9 ---------- --------HP EMA------- DQAHMPYTNA VIHEVQRFG- Cyp2d10 ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFG- Cyp2d11 ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFGT Cyp2d12 ---------- --------HP EMA------- DQAHMPYTNA VIHEVQRFG- Cyp2d13 ---------- --------CP EMA------- DQAHMPYTNA VIHEVQRFA- Cyp2d22 ---------- --------CP EMA------- DQARMPYTNA VIHEVQRFA- Cyp2d26 ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFA- Cyp2e1 ---------- --------AP AVR------- DRMNMPYMDA VVHEIQRFI- Cyp2f2 ---------- --------MP TLE------- DRTSMPYTDA VIHEVQRFA- Cyp2g1 ---------- --------TP RVD------- DRAKMPYTDA VIHEIQRLT- Cyp2j5 ---------- --------QV SLS------- DRESMPYTNA VIHEVQRMG- Cyp2j6 ---------- --------AA RLA------- DRESMPYTNA VIHEVRRMG- Cyp2j7 ---------- --------QP STG------- DRDSMPYTNA VIHEVLRMG- Cyp2j8 ---------- --------HP TID------- DRDSMPYTNA VIHEVLRMG- Cyp2j9 ---------- --------QP NLA------- DRDSMPYTNA VIHEVQRMG- Cyp2j13 ---------- --------HP SLA------- DRDSMPYTNA VVHEILRMG- Cyp2j12 ---------- --------QP STD------- DRDSMPYTNA VIHEVLRMG- cyp2j11 ---------- --------HP TLD------- DQDSMPYTNA VIHEVLRMG- Cyp2r1 ---------- --------RP SWE------- YKCKMPYTEA VLHEVLRFC- Cyp2s1 ---------- --------AP SLS------- DRVRLPYTDA VLHEAQRLL- Cyp2t4 ---------- --------AP RIE------- DRARLPYTNA VLHEIQRFI- Cyp2U1 ---------- --------AP SLT------- DKAQMPYTEA TIMEVQRLS- Cyp2w1 ---------- --------LP QPE------- HQRALPYTSA VLHEVQRYI- CYP2W1h ---------- --------TP RLE------- DQQALPYTSA VLHEVQRFI- Cyp3a11 PP-------- --------TY DTVME----- ----MEYLDM VLNETLRLYP Cyp3a13 PA-------- --------TY DTLLQ----- ----MEYLDM VVNETLRLYP Cyp3a16 PP-------- --------TY DTVMA----- ----MEYLDM VLNETLRLYP Cyp3a25 PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP Cyp3a57 PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP Cyp3a41 PP-------- --------TY DTVME----- ----MEYLDM VLNETLRLYP Cyp3a44 TP-------- --------TC DTVME----- ----MEYLDM VLNETLRLYP Cyp4a10 S--------- ---------I TWD------- HLDQIPYTTM CIKEALRLYP Cyp4a12 S--------- ---------I TWN------- DLDKMPYTTM CIKEALRIYP Cyp4a14 S--------- ---------V TWD------- HLGQMPYTTM CIKEALRLYP Cyp4a30 S--------- ---------V TN-------- HLDQMPYTTM CIKEALRLYP Cyp4a29 P--------- ---------I TWD------- HLHQMPYTTM CIKEALRLYP Cyp4b1 S--------- ---------F QWD------- DLAQMTYLTM CMKECFRLYP Cyp4f13 SE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP Cyp4f14 PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP Cyp4f15 ST-------- --------EI ECSCAVFLRD DLAQLPFLTM CIKESLRLHP Cyp4f16 PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHS Cyp4f17 PQ-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP Cyp4f18 PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP Cyp4f37 PQ-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP Cyp4f39 LE-------- --------EL DWD------- DLTQLPFTTM CIKESLRQFP Cyp4f40 PK-------- --------EI EW-------D DLAQLPFLTM CIKESLRLHP Cyp4v3 RP-------- --------VT LED------- -LKKLKYLDC VIKETLRVFP Cyp4x1 S--------- ---------I TWE------- QLDEMSYTTM CIKETLRLIP Cyp5a1 AP-------- --------EY HSLQEG---- ----LPYLDM VISETLRMYP Cyp7a1 SS-------- ----GGNAIY LDQE------ QLNNLPVLDS IIKEALRLSS Cyp7b1 G--------- ----PGISVH FTRE------ QLDSLVCLES TILEVLRLCS Cyp8a1 S--------- ------QMTT LPQK------ ILDSMPVLDS VLNETLRLTA Cyp8b1 K--------- ------KSFT FTPS------ ALKHTPVLDS VMEESLRLCA Cyp11a1 ---------- --------GD MAK------- MVQLVPLLKA SIKETLRLH- Cyp11b1 ---------- --------AN PQK------- AMSDLPLLRA ALKETLRLY- Cyp11b2 ---------- --------AN PQK------- AMSDLPLLRA ALKETLRLY- Cyp17 ---------- --------TP SFN------- DRTHLLMLEA TIREVLRIR- Cyp19 ---------- --------DI KIE------- DIQNLKVVEN FINESMRYQ- Cyp20 PI-------- --------TS EK-------- -IEQLSYCQQ VLFETVRTAK Cyp21 ---------- --------QL LYR------- NRMQLPLLMA TIAEVLRLR- Cyp24 ---------- --------TP RAE------- DVRNMPYLKA CLKESMRLT- Cyp26a1 D--------- --------NK LDME------ TLEQLKYIGC VIKETLRLNP Cyp26b1 P--------- ------CEGT LRLD------ TLSSLRYLDC VIKEVMRLFT Cyp26c1 TPRASGS--- -PPDCGCEPD LSLA------ MLGRLRYVDC VVKEVLRLLP Cyp27a1 ---------- --------VP QHK------- DFAHMPLLKA VIKETLRLY- Cyp27b1 ---------- --------HP HGT------- ALSQLPLLKA VIKEVLRLY- Cyp39 ---------- --------IK VSED------ DLKKLLIIKW CILESVRLRA Cyp46 HL-------- --------DY ED-------- -LGRLQYLSQ VLKESLRLYP Cyp51 ---------- ---------- LTYD------ QLKDLNLLDR CIKETLRLRP CYP1A1h ---------- --------RP RLS------- DRSHLPYMEA FILETFRHS- CYP1A2h ---------- --------RP RLS------- DRPQLPYLEA FILETFRHS- CYP1B1h ---------- --------LP CMG------- DQPNLPYVLA FLYEAMRFS- CYP2A6 ---------- --------QP KFE------- DRAKMPYMEA VIHEIQRFG- CYP2A7 ---------- --------QP KFE------- DRTKMPYMEA VIHEIQRFG- CYP2A13 ---------- --------QP KFE------- DRAKMPYTEA VIHEIQRFG- CYP2B6 ---------- --------PP ELH------- DRAKMPYTEA VIYEIQRFS- CYP2C8 ---------- --------SP CMQ------- DRSHMPYTDA VVHEIQRYS- CYP2C9 ---------- --------SP CMQ------- DRSHMPYTDA VVHEVQRYI- CYP2C18 ---------- --------SP CMQ------- DRSHMPYTDA VVHEIQRYI- CYP2C19 ---------- --------SP CMQ------- DRGHMPYTDA VVHEVQRYI- CYP2D6 ---------- --------RP EMG------- DQAHMPYTTA VIHEVQRFG- CYP2E1h ---------- --------IP AIK------- DRQEMPYMDA VVHEIQRFI- CYP2F1 ---------- --------LP ALK------- DRAAMPYTDA VIHEVQRFA- CYP2G2P ---------- --------LP RVD------- DRVKMPYTDA VIHEIQRLV- CYP2J2 ---------- --------QP STA------- ARESMPYTNA VIHEVQRMG- CYP2R1h ---------- --------KP SWD------- DKCKMPYTEA VLHEVLRFC- CYP2S1h ---------- --------AP SLG------- DRTRLPYTDA VLHEAQRLL- CYP2T2P ---------- --------AP SLD------- YRVCLPYANA VLLEIQCFI- CYP2U1h ---------- --------AP SLT------- DKAQMPYTEA TIMEVQRLT- CYP3A4 PP-------- --------TY DTVLQ----- ----MEYLDM VVNETLRLFP CYP3A5 PP-------- --------TY DAVVQ----- ----MEYLDM VVNETLRLFP CYP3A7 PP-------- --------TY DTVLQ----- ----LEYLDM VVNETLRLFP CYP3A43 PV-------- --------TY DALVQ----- ----MEYLDM VVNETLRLFP CYP4A11 S--------- ---------I TWN------- HLDQMPYTTM CIKEALRLYP CYP4A22 S--------- ---------I TWN------- HLDQMPYTTM CIKEALRLYP CYP4B1h F--------- ---------F QWD------- DLGKMTYLTM CIKESFRLYP CYP4F2 PK-------- --------EI EWD------- DLAHLPFLTM CMKESLRLHP CYP4F3 PK-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP CYP4F8 PK-------- --------EI EWD------- DLAQLPFLTM CLKESLRLHP CYP4F11 PI-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP CYP4F12 PK-------- --------EI EWD------- DLAQLPFLTM CVKESLRLHP CYP4F22 LE-------- --------EL EWD------- DLTQLPFTTM CIKESLRQYP CYP4F23P PK-------- --------EI EWD------- DLAQLPFLTM CLKESLRLHS CYP4V2 RP-------- --------AT VED------- -LKKLRYLEC VIKETLRLFP CYP4X1h S--------- ---------I TWD------- QLGEMSYTTM CIKETCRLIP CYP4Z1 S--------- ---------I TWE------- HLSQMPYTTM CIKECLRLYA CYP5A1h AP-------- --------EF CSLEEG---- ----LPYLDM VIAETLRMYP CYP7A1h SL-------- ----EGNPIC LSQA------ ELNDLPVLDS IIKESLRLSS CYP7B1h G--------- ----SGFPIH LTRE------ QLDSLICLES SIFEALRLSS CYP8A1h S--------- ------QTTT LPQK------ VLDSTPVLDS VLSESLRLTA CYP8B1h K--------- ------QSFA FKLG------ ALQHTPVLDS VVEETLRLRA CYP11A1h ---------- --------GD MAT------- MLQLVPLLKA SIKETLRLH- CYP11B1h ---------- --------EH PQK------- ATTELPLLRA ALKETLRLY- CYP11B2h ---------- --------EH PQK------- ATTELPLLRA ALKETLRLY- CYP17h ---------- --------TP TIS------- DRNRLLLLEA TIREVLRLR- CYP19h ---------- --------DI KID------- DIQKLKVMEN FIYESMRYQ- CYP20h PV-------- --------TP EK-------- -IEQLRYCQH VLCETVRTAK CYP21A2h SS-------- --------RV PYK------- DRARLPLLNA TIAEVLRLR- CYP24h ---------- --------RP REE------- DLRNMPYLKA CLKESMRLT- CYP26A1h D--------- --------NK LDME------ ILEQLKYIGC VIKETLRLNP CYP26B1h P--------- ------CEGT LRLD------ TLSGLRYLDC VIKEVMRLFT CYP26C1h APGAAGGSEG PPPDCGCEPD LSLA------ ALGRLRYVDC VVKEVLRLLP CYP27A1h ---------- --------VP QHK------- DFAHMPLLKA VLKETLRLY- CYP27B1h ---------- --------YP SAT------- VLSQLPLLKA VVKEVLRLY- CYP27C1h ---------- --------VP TAA------- DVPKVPLVRA LLKETLRLF- CYP39A1h ---------- --------IK VSED------ DLENLLLIKW CVLETIRLKA CYP46h YL-------- --------DF ED-------- -LGRLQYLSQ VLKESLRLYP CYP51h ---------- ---------- LTYD------ QLKDLNLLDR CIKETLRLRP Cyp1a1 SFVPFTIPHS TTRDT----- ----SLNGFY IPKGCCVFVN QWQ-VNHDRE Cyp1a2 SFVPFTIPHS TTRDT----- ----SLNGFH IPKERCIYIN QWQ-VNHDEK Cyp1b1 SFLPVTIPHA TTANT----- ----FVLGYY IPKNTVVFVN QWS-VNHDPA Cyp2a4 DLIPMGLARR VTKDT----- ----KFRDFL LPKGTEVFPM LGS-VLKDPK Cyp2a5 DMIPMGLARR VTKDT----- ----KFRDFL LPKGTEVFPM LGS-VLKDPK Cyp2a12 NFAPLGIPRR ITKNT----- ----SFRGFF LPKATEVFPI LGS-LMTDPK Cyp2b9 DLVPIGLPHK VIKDT----- ----LFRGYL LPKNTEVYPV LSS-ALHDPQ Cyp2b10 DLIPIGVPHR VTKDT----- ----MFRGYL LPKNTEVYPI LSS-ALHDPQ Cyp2b13 DIVPTGAPHR VTKDT----- ----MFRGYL LPKNTEVYPI LSS-ALHDPQ Cyp2b19 DLAPIGLPHK VTKDT----- ----LFRGYL IPKNTEVYPI LSS-ALHDPR Cyp2b23 DLAPIGLPHT VTKDT----- ----VFRGYL LPKNTEVYPI LSS-ALHDPQ Cyp2c29 DLLPTSLPHA VTCDI----- ----KFRKYL IPKGTTVITS LSS-VLHDSK Cyp2c37 DLIPNSLPHE VTCDI----- ----KFRNYF IPKGTTVITS LSS-VLHDST Cyp2c38 NLVPNNLPHA VTCDI----- ----KFRNYI IPKGTTVVTS LTS-VLHDSK Cyp2c39 NLVPNNIPRA VTCDI----- ----KFRNYL IPKGTTVVTS LTS-VLHDSK Cyp2c40 DLGPNGVVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST Cyp2c44 TLLPSSLPHA VVQDT----- ----KFRHYV IPKGTAVFPF LSS-ILLDQK Cyp2c50 DLVPNSLPHE VTCDI----- ----KFRNYF IPKGTNVITS LSS-VLRDSK Cyp2c54 DLVPNNLPHE VTCDI----- ----KFRNYF IPKGTTVITS LSS-VLRDSK Cyp2c55 DLIPNNVPHA ATCNV----- ----RFRSYF IPKGTELVTS LTS-VLHDDK Cyp2c65 DLLPTSLPHA VTRDV----- ----KFREYL IPKGTTVIAS LTS-VLYDDK Cyp2c66 DLLPTSLPHA VTRDV----- ----KFREYL IPKGTTVIAS LTS-VLYDDK Cyp2c67 DLGPISLVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST Cyp2c68 DLGPNGVVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST Cyp2c69 DLGPTSLVHE VTCDT----- ----KFRNYF IPKGTQVMTS LSS-VLHDST Cyp2c70 DFVPIPSPRK TTQDV----- ----EFRGYH IPKGTSVMAC LTS-VLNDDK Cyp2d9 DIVPVNLPRI TSHDI----- ----EVQDFL IPKGTILLPN MSS-MLKDES Cyp2d10 DIAPLNLPRI TSRDI----- ----EVQDFL IPKGSILIPN MSS-VLKDET Cyp2d11 LLHCLCHASQ VVTFT----- ----QVQDFL VTKGSTLIPN LSS-VLKGET Cyp2d12 DIVPLHLPRI TSRDI----- ----EVQDFL IPKGTILLPN MSS-VHMDDT Cyp2d13 DIVPMNLPHK TSHDI----- ----EVQGFL IPKGTTLIPN LSS-ALKDET Cyp2d22 DILPLGVPHK TSRDI----- ----ELQGFL IPKGTTLITN LSS-ALKDET Cyp2d26 DIVPTNLPHM TSRDI----- ----KFQDFF IPKGTTLIPN LSS-VLKDET Cyp2e1 NLVPSNLPHE ATRDT----- ----VFRGYV IPKGTVVIPT LDS-LLFDNY Cyp2f2 DVIPMNLPHR VTRDT----- ----PFRGFL IPKGTDVITL LNT-VHYDSD Cyp2g1 DIVPLGVPHN VTRDT----- ----HFRGYL LPKGTDVYPL FGS-VLKDPK Cyp2j5 NIVPLNSSRE VTVDT----- ----KFNGFH LPKGTMILTN LTA-LHRDPK Cyp2j6 NIIPLNVPRE VAMDT----- ----NLNGFH LPKGTMVLTN LTA-LHRDPK Cyp2j7 NIVPLNVPRE VTADS----- ----TLAGFH LPKGKMILTN LTA-LHRDPK Cyp2j8 NIIPLNVPRE VEADI----- ----TLAGFH LPKGTMVLTN LTA-LHRDPK Cyp2j9 NIIPFNVPRE VAVDT----- ----QLAGFN LPKGIMVLSN LTA-LHRDPS Cyp2j13 NSVPLNIPRE VAVDT----- ----TLAGFH LPKRSVVMTN LTA-LHMDPK Cyp2j12 NILPMNVPRE VTADS----- ----TLAGFH LPKGTMVLTN LTA-LHRDPK cyp2j11 NIIPLNVPRE VTADS----- ----TLAGFY LPKGTMVLIN LTD-LHRDPK Cyp2r1 NIVPLGIFHA TSEDA----- ----VVRGYS IPKGTTVITN LYS-VHFDEK Cyp2s1 ALVPMGMPHT ITRTT----- ----CFRGYT LPKGTEVFPL IGS-ILHDPA Cyp2t4 SVLPLGLPRA LTRDV----- ----NLKNHF LHKGTFVIPL LVS-AHRDPT Cyp2U1 MVVPLAIPHM TSEKT----- ----VLQGFT IPKGTVVLIN LWS-VHRDPA Cyp2w1 TLLP-HVPRC TAADI----- ----QLGGYL LPKGTPVIPL LTS-VLLDKT CYP2W1h TLLP-HVPRC TAADT----- ----QLGGFL LPKGTPVIPL LTS-VLLDET Cyp3a11 IANRLERVCK KDVELN---- ------G-VY IPKGSTVMIP SYA-LHHDPQ Cyp3a13 IAGRLERVCK TDVEIN---- ------G-LF IPKGTVVMIP TFA-LHKDPK Cyp3a16 ITNRLQRVCK KDVEIN---- ------G-IY IPKGSTVIIP SYV-LHHDPQ Cyp3a25 IAIRLERVSK KDVEIN---- ------G-VF IPKGTVVMIP IYP-LHRNPE Cyp3a57 VVSRIDRFSK KDVEIH---- ------G-VF IPKGTIVMIP IYP-LHRDPE Cyp3a41 IGNRLERFCK KDVELN---- ------G-VY IPKGSTVMIP SYA-LHHDPQ Cyp3a44 IVTRLERVCK KDVELN---- ------G-VY IPKGSMVMIP SYA-LHHDPQ Cyp4a10 PVPGIVRELS TSVTFP---- ------DGRS LPKGVQVTLS IYG-LHHNPK Cyp4a12 PVPSVSRELS SPVTFP---- ------DGRS LPKGIHVMLS FYG-LHHNPT Cyp4a14 PVISVSRELS SPVTFP---- ------DGRS IPKGITATIS IYG-LHHNPR Cyp4a30 PIPGASRELS SPVTFP---- ------DGCS LPKGFLVTLS FYG-LHHNPR Cyp4a29 PIPSVGRKLS TPVTFP---- ------DGRS LPKGIESTVS CFI-FFSAWK Cyp4b1 PVPQVYRQLS KPVTFV---- ------DGRS LPAGSLISLH IYA-LHRNSA Cyp4f13 PVLLISRCCT QDVLLP---- ------DGRA IPKGNICVIS IFG-VHHNPS Cyp4f14 PVTVISRCCT QDILLP---- ------DGRT IPKGIICLIS IFG-IHHNPS Cyp4f15 PVTVISRRCT QDIVLP---- ------DGRV IPKGVICIIN IFA-THHNPT Cyp4f16 PVIDLLRRCT RDIVLP---- ------DGRV IPKGNICVIS IFG-IHHNPS Cyp4f17 PVTVISRCCT QDVVLP---- ------DGRV IPKGTDCVIS IFG-VHHNPE Cyp4f18 PVTAISRCCT QDIVLP---- ------DGRV IPKGVISRIS IFG-THHNPA Cyp4f37 PVIDLLRRCT RDIVLP---- ------DGRV IPKGNICVIS IFG-IHHNPS Cyp4f39 PVTLISRRCT EDIKLP---- ------DGRV IPKGIICLVS IYG-THHNPI Cyp4f40 PVTMVSRCCT QDISLP---- ------DGRI IPKGVICIIN IFG-THHNPT Cyp4v3 SVPLFARSLS EDCEVG---- ------G-YK VTKGTEAIII PYA-LHRDPR Cyp4x1 PVPSISRELS KPLTLP---- ------DGHS LPAGMTVVLS IWG-LHHNPA Cyp5a1 PAFRFTREAA QDCEVL---- ------G-QR IPAGTVLEIA VGA-LHHDPE Cyp7a1 ASLNIRTAKE DFTLHLED-- -----G-SYN IRKDDIIALY PQL-MHLDPE Cyp7b1 YSSIIREVQE DMNLSLES-- -----K-SFS LRKGDFVALF PPL-IHNDPE Cyp8a1 APFITREVMA DLALPMAD-- -----GREFS LRRGDRLLLF PFLSPQKDPE Cyp8b1 TPTLLRVVQE DYVLKMAS-- -----GQEYQ IRRGDKVALF PYLSVHMDPD Cyp11a1 PISVTLQ-RY TVNDL----- ----VLRNYK IPAKTLVQVA SFA-MGRDPG Cyp11b1 PVGTFLE-RI LSSDL----- ----VLQNYH VPAGTVLNVN LYS-MGRNPA Cyp11b2 PVGGFLE-RI LSSDL----- ----VLQNYH VPAGTLVLLY LYS-MGRNPA Cyp17 PVAPLLIPHK ANIDS----- ----SIGEFA IPKDTHVIIN LWA-LHHDKN Cyp19 PVVDLVMRRA LEDDV----- -----IDGYP VKKGTNIILN IGR-MHRLEY Cyp20 LTPVSARLQD IEGKVG---- ------P-FV IPKETLVLYA LGV-VLQDPS Cyp21 PVVPLALPHR ATRAS----- ----SISGYD IPKDMVIIPN IQG-ANLDEM Cyp24 PSVPFTT-RT LDKPT----- ----VLGEYT LPKGTVLTLN TQV-LGSSED Cyp26a1 PVPGGFRVAL KTFELNG--- --------YQ IPKGWNVIYS ICDTHDVADI Cyp26b1 PVSGGYRTVL QTFELDG--- --------FQ IPKGWSVMYS IRDTHDTAPV Cyp26c1 PVSGGYRTAL RTFELDG--- --------YQ IPKGWSVMYS IRDTHETAAV Cyp27a1 PVVPTNSRII TEKET----- ----EINGFL FPKNTQFVLC HYV-VSRDPS Cyp27b1 PVVPGNS-RV PDRDI----- ----RVGNYV IPQDTLVSLC HYA-TSRDPT Cyp39 PGVITRKVVK PVKILN---- --------HT VPSGDLLMLS PFW-LHRNPK Cyp46 PAWGTFRLLE EETLID---- ------G-VR VPGNTPLLFS TYV-MGRMDT Cyp51 PIMTMMRMAK TPQTVAG--- --------YT IPPGHQVCVS PTV-NQRLKD CYP1A1h SFVPFTIPHS TTRDT----- ----SLKGFY IPKGRCVFVN QWQ-INHDQK CYP1A2h SFLPFTIPHS TTRDT----- ----TLNGFY IPKKCCVFVN QWQ-VNHDPE CYP1B1h SFVPVTIPHA TTANT----- ----SVLGYH IPKDTVVFVN QWS-VNHDPV CYP2A6 DVIPMSLARR VKKDT----- ----KFRDFF LPKGTEVYPM LGS-VLRDPS CYP2A7 DVIPMSLARR VKKDT----- ----KFRDFF LPKGTEVFPM LGS-VLRDLR CYP2A13 DMLPMGLAHR VNKDT----- ----KFRDFF LPKGTEVFPM LGS-ELRDPR CYP2B6 DLLPMGVPHI VTQHT----- ----SFRGYI IPKDTEVFLI LST-ALHDPH CYP2C8 DLVPTGVPHA VTTDT----- ----KFRNYL IPKGTTIMAL LTS-VLHDDK CYP2C9 DLLPTSLPHA VTCDI----- ----KFRNYL IPKGTTILIS LTS-VLHDNK CYP2C18 DLLPTNLPHA VTCDV----- ----KFKNYL IPKGTTIITS LTS-VLHNDK CYP2C19 DLIPTSLPHA VTCDV----- ----KFRNYL IPKGTTILTS LTS-VLHDNK CYP2D6 DIVPLGMTHM TSRDI----- ----EVQGFR IPKGTTLITN LSS-VLKDEA CYP2E1h TLVPSNLPHE ATRDT----- ----IFRGYL IPKGTVVVPT LDS-VLYDNQ CYP2F1 DIIPMNLPHR VTRDT----- ----AFRGFL IPKGTDVITL LNT-VHYDPS CYP2G2P DIVPMGVPHN LIRDT----- ----QFRGYL LPKGTDVFPL LGS-VLKDPK CYP2J2 NIIPQNVPRE VTVDT----- ----TLAGYH LPKGTMILTN LTA-LHRDPT CYP2R1h NIVPLGIFHA TSEDA----- ----VVRGYS IPKGTTVITN LYS-VHFDEK CYP2S1h ALVPMGIPRT LMRTT----- ----RFRGYT LPQGTEVFPL LGS-ILHEPN CYP2T2P SVVPLGLPRT LTLDT----- ----HLHSHC LPKGTFVIPL LVT-AHRDPT CYP2U1h VVVPLAIPHM TSENT----- ----VLQGYT IPKGTLILPN LWS-VHRDPA CYP3A4 IAMRLERVCK KDVEIN---- ------G-MF IPKGWVVMIP SYA-LHRDPK CYP3A5 VAIRLERTCK KDVEIN---- ------G-VF IPKGSMVVIP TYA-LHHDPK CYP3A7 VAMRLERVCK KDVEIN---- ------G-MF IPKGVVVMIP SYV-LHHDPK CYP3A43 VVSRVTRVCK KDIEIN---- ------G-VF IPKGLAVMVP IYA-LHHDPK CYP4A11 PVPGIGRELS TPVTFP---- ------DGRS LPKGIMVLLS IYG-LHHNPK CYP4A22 PVPGIGRELS TPVTFP---- ------DGRS LPKGIMVLLS IYG-LHHNPK CYP4B1h PVPQVYRQLS KPVTFV---- ------DGRS LPAGSLISMH IYA-LHRNSA CYP4F2 PVPVISRHVT QDIVLP---- ------DGRV IPKGIICLIS VFG-THHNPA CYP4F3 PVPAVSRCCT QDIVLP---- ------DGRV IPKGIICLIS VFG-THHNPA CYP4F8 PIPTFARGCT QDVVLP---- ------DSRV IPKGNVCNIN IFA-IHHNPS CYP4F11 PVPVISRCCT QDFVLP---- ------DGRV IPKGIVCLIN IIG-IHYNPT CYP4F12 PAPFISRCCT QDIVLP---- ------DGRV IPKGITCLID IIG-VHHNPT CYP4F22 PVTLVSRQCT EDIKLP---- ------DGRI IPKGIICLVS IYG-THHNPT CYP4F23P PVSRIHRCCP QDGVLP---- ------DGRV IPKGNTCTIS IFG-IHHNPS CYP4V2 SVPLFARSVS EDYFLT---- ------AGYR VLKGTEAVII PYA-LHRDPR CYP4X1h AVPSISRDLS KPLTFP---- ------DGCT LPAGITVVLS IWG-LHHNPA CYP4Z1 PVVNISRLLD KPITFP---- ------DGRS LPAGITVFIN IWA-LHHNPY CYP5A1h PAFRFTREAA QDCEVL---- ------G-QR IPAGAVLEMA VGA-LHHDPE CYP7A1h ASLNIRTAKE DFTLHLED-- -----G-SYN IRKDSIIALY PQL-MHLDPE CYP7B1h YSTTIRFVEE DLTLSSET-- -----G-DYC VRKGDLVAIF PPV-LHGDPE CYP8A1h APFITREVVV DLAMPMAD-- -----GREFN LRRGDRLLLF PFLSPQRDPE CYP8B1h APTLLRLVHE DYTLKMSS-- -----GQEYL FRHGDILALF PYLSVHMDPD CYP11A1h PISVTLQ-RY LVNDL----- ----VLRDYM IPAKTLVQVA IYA-LGREPT CYP11B1h PVGLFLE-RV ASSDL----- ----VLQNYH IPAGTLVRVF LYS-LGRNPA CYP11B2h PVGLFLE-RV VSSDL----- ----VLQNYH IPAGTLVQVF LYS-LGRNAA CYP17h PVAPMLIPHK ANVDS----- ----SIGEFA VDKGTEVIIN LWA-LHHNEK CYP19h PVVDLVMRKA LEDDV----- -----IDGYP VKKGTNIILN IGR-MHRLEF CYP20h LTPVSAQLQD IEGKID---- ------R-FI IPRETLVLYA LGV-VLQDPN CYP21A2h PVVPLALPHR TTRPS----- ----SISGYD IPEGTVIIPN LQG-AHLDET CYP24h PGVPFTT-RT LDKAT----- ----VLGEYA LPKGTVLMLN TQV-LGSSED CYP26A1h PVPGGFRVAL KTFELNG--- --------YQ IPKGWNVIYS ICDTHDVAEI CYP26B1h PISGGYRTVL QTFELDG--- --------FQ IPKGWSVMYS IRDTHDTAPV CYP26C1h PVSGGYRTAL RTFELDG--- --------YQ IPKGWSVMYS IRDTHETAAV CYP27A1h PVVPTNS-RI IEKEI----- ----EVDGFL FPKNTQFVFC HYV-VSRDPT CYP27B1h PVVPGNS-RV PDKDI----- ----HVGDYI IPKNTLVTLC HYA-TSRDPA CYP27C1h PVLPGNG-RV TQEDL----- ----VIGGYL IPKGTQLALC HYA-TSYQDE CYP39A1h PGVITRKVVK PVEILN---- --------YI IPSGDLLMLS PFW-LHRNPK CYP46h PAWGTFRLLE EETLID---- ------G-VR VPGNTPLLFS TYV-MGRMDT CYP51h PIMIMMRMAR TPQTVAG--- --------YT IPPGHQVCVS PTV-NQRLKD Cyp1a1 LWGDPNEFRP ERFLTPSG-- -TLDKR---- LSEKVTLFGL G--KRKCIGE Cyp1a2 QWKDPFVFRP ERFLTNNNS- -AIDKT---- QSEKVMLFGL G--KRRCIGE Cyp1b1 KWPNPEDFDP ARFLDKDG-- -FINKA---- LASSVMIFSV G--KRRCIGE Cyp2a4 FFSNPKDFNP KHFLDDKG-- ---QFK---- KSDAFVPFSI G--KRYCFGE Cyp2a5 FFSNPKDFNP KHFLDDKG-- ---QFK---- KNDAFVPFSI G--KRYCFGE Cyp2a12 FFSSPKDFNP QHFLDDKG-- ---QLK---- KIPAFLPFST G--KRFCLGD Cyp2b9 YFEQPDKFNP EHFLDANG-- ---ALK---- KCEAFLPFST G--KRICLGE Cyp2b10 YFEQPDSFNP DHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE Cyp2b13 YFEQPDSFNP DHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE Cyp2b19 YFEQPDSFNP EHFLDANG-- ---ALK---- TNEAFMPFST G--KRICLGE Cyp2b23 YFEQPDKFNP EHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE Cyp2c29 EFPNPEMFDP GHFLNGNG-- ---NFK---- KSDYFMPFST G--KRICAGE Cyp2c37 EFPNPEVFDP GHFLDGNG-- ---KFK---- KSDYFMPFST G--KRICAGE Cyp2c38 EFPNPEMFDP GHFLDANG-- ---NFK---- KSDYFMTFSA G--KRVCAGE Cyp2c39 EFPNPELFDP GHFLDANG-- ---NFK---- KSDHFMPFSA G--KRVCAGE Cyp2c40 EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFMPFSA G--KRICVGE Cyp2c44 EFPNPEKFDP GHFLDKNG-- ---CFK---- KTDYFVPFSL G--KRSCVGE Cyp2c50 EFPNPEKFDP GHFLDENG-- ---KFK---- KSDYFMPFST G--KRICAGE Cyp2c54 EFPNPEKFDP GHFLDENG-- ---KFK---- KSDYFMPFST G--KRICAGE Cyp2c55 EFPNPEVFDP GHFLDENG-- ---NFK---- KSDYFMPFSI G--KRMCVGE Cyp2c65 EFPNPEKFDP SHFLDERG-- ---KFK---- KSDYFFPFST G--KRICVGE Cyp2c66 EFLNPERFDP SHFLDESG-- ---KFK---- KSDYFFPFST G--KRICVGE Cyp2c67 EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA G--KRICVGE Cyp2c68 EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA ---------- Cyp2c69 EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA G--KRICVGE Cyp2c70 EFPNPEKFDP GHFLDEKG-- ---NFK---- KSDYFVAFSA G--RRACIGE Cyp2d9 VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE Cyp2d10 VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE Cyp2d11 VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--HRSCLGE Cyp2d12 VWEKPLRFHP EHFLDAQG-- ---HFV---- KHEAFITFSA G--RRSCLGE Cyp2d13 VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRACLGE Cyp2d22 VWEKPLCFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE Cyp2d26 VWEKPLRFYP EHFLDAQG-- ---HFV---- KHEAFMPFSA G--RRSCLGE Cyp2e1 EFPDPETFKP EHFLNENG-- ---KFK---- YSDYFKAFSA G--KRVCVGE Cyp2f2 QFKTPQEFNP EHFLDDNH-- ---SFK---- KSPAFMPFSA G--RRLCLGE Cyp2g1 YFRYPDAFYP QHFLDEQG-- ---RFK---- KNDAFVVFSS G--KRICVGE Cyp2j5 EWATPEVFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE Cyp2j6 EWATPDVFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE Cyp2j7 EWATPDIFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACPGE Cyp2j8 EWATPDVFNP EHFLE-NG-- ---QFK---- KRESFLPFSV G--KRGCPGE Cyp2j9 EWTTPDTFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE Cyp2j13 EWATPDIFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE Cyp2j12 EWATPNTFNP EHFLE-NG-- ---QFK---- KRESFLPFSL G--KRACPGE cyp2j11 EWDTPNVFNP EHFLE-NG-- ---QFK---- KKESFLPFSM G--KRACPGE Cyp2r1 YWKDPDMFYP ERFLDSNG-- ---YFT---- KKEALIPFSL G--RRHCLGE Cyp2s1 VFQNPGEFHP GRFLDEDG-- ---RLR---- KHEAFLPYSL G--KRVCLGE Cyp2t4 QFKDPDHFNP TNFLDDHG-- ---EFQ---- NNDAFMPFAL G--KRMCLGA Cyp2U1 IWEKPDDFCP HRFLDDQG-- ---QLL---- KRETFIPFGI G--------- Cyp2w1 QWETPSQFNP NHFLDAKG-- ---RFM---- KRGAFLPFSA G--RRVCVGK CYP2W1h QWQTPGQFNP GHFLDANG-- ---HFV---- KREAFLPFSA G--RRVCVGE Cyp3a11 HWSEPEEFQP ERFSKENK-- -------GSI DPYVYLPFGN G--PRNCLGM Cyp3a13 YWPEPEEFRP ERFSKKNQ-- -------DSI NPYMYLPFGS G--PRNCIGM Cyp3a16 HWPEPEEFQP ERFSKENK-- -------GSI DPYVYLPFGN G--PRNCIGM Cyp3a25 YWPEPQEFCP ERFSKENK-- -------GNI DPYIYMPFGN G--PRNCIGM Cyp3a57 YWPEPEDFCP ERFSKENK-- -------GNI DPYIYMPFGN G--PRNCIGM Cyp3a41 HWPEPEEFQP ERFSKENK-- -------GSI DPYLYMPFGI G--PRNCIGM Cyp3a44 HWPDPEEFQP ERFSKENK-- -------GSI DPYVYLPFGI G--PRNCIGM Cyp4a10 VWPNPEVFDP SRFAPD---- -------SPR HSHSFLPFSG G--ARNCIGK Cyp4a12 VWPNPEVFDP SRFAPG---- -------SSR HSHSFLPFSG G--ARNCIGK Cyp4a14 FWPNPKVFDP SRFAPD---- -------SSH HSHAYLPFSG G--SRNCIGK Cyp4a30 LRPNAEVFDP SRFAPG---- -------APR QTHAFLPFSA G--TRNCIGK Cyp4a29 AFDKPEVFDP SRFAMN---- -------SVQ HSHAFLPFSG G--SRNCIGK Cyp4b1 VWPDPEVFDP LRFSPENM-- -------TGR HPFAFMPFSA G--PRNCIGQ Cyp4f13 VWPDPEVYNP FRFDPENP-- -------QKR SPLAFIPFSA G--TRNCIGQ Cyp4f14 VWPDPEVYDP FRFDPENI-- -------KDS SPLAFIPFSA G--PRNCIGQ Cyp4f15 VWPDPEVYDP FRFDPENI-- -------KDR SPLAFIPFSA G--PRNCIGQ Cyp4f16 VWPDPEVYDP FRFDPENP-- -------QKR SPLAFIPFSA G--PRNCIGQ Cyp4f17 VWPDPEVYDP FRFDPENP-- -------QKR SPLAFIPFSA G--PRNCIGQ Cyp4f18 VWPDPEVYDP FRFDADNV-- -------KGR SPLAFIPFSA G--PRNCIGQ Cyp4f37 VWPDPEVYDP FRFDPENA-- -------HKR PPLAFIPFSA G--PRNCIGQ Cyp4f39 VWPDSKVYNP YRFDPDTP-- -------QQR SPLAFVPFSA G--PRNCIGQ Cyp4f40 VWRDPEVYDP FRFDPENI-- -------QAR SPLSFIPFSA G--PRNCIGQ Cyp4v3 YFPDPEEFRP ERFFPENS-- -------QGR HPYAYVPFSA G--PRNCIGQ Cyp4x1 VWNDPKVFDP LRFTKENS-- -------DQR HPCAFLPFSS G--PRNCIGQ Cyp5a1 HWPNPETFDP ERFTAEAR-- -------LQR RPFTYLPFGA G--PRSCLGV Cyp7a1 IYPDPLTFKY DRYLDESGKA KTTFYRNGNK LKYFYMPFGS G--ATICPGR Cyp7b1 IFDAPKEFRF DRFIED-GKK KSTFFKGGKR LKTYVMPFGL G--TSKCPGR Cyp8a1 IYTEPEVFKY NRFLNPDGSE KKDFYKDGKR LKNYNMPWGA G--HNQCLGK Cyp8b1 IHPEPTAFKY DRFLNPDGTR KVDFYKSGKK IHHYSMPWGS G--VSKCPGR Cyp11a1 FFPNPNKFDP TRWLEKSQ-- ---NT----- THFRYLGFGW G--VRQCLGR Cyp11b1 VFPRPERYMP QRWLERK--- ---------- RSFKHLAFGF G--VRQCLGR Cyp11b2 VFPRPERYMP QRWLERK--- ---------- RSFQHLAFGF G--VRQCLGR Cyp17 EWDQPDRFMP ERFLDPTG-- -SHLIT---- PTPSYLPFGA G--PRSCIGE Cyp19 -FPKPNEFTL ENFEKNVP-- ---------- -YRYFQPFGF G--PRGCAGK Cyp20 TWPLPHRFDP DRFADE---- -------PVM KVFSSLGFSG ---TWECPEL Cyp21 VWELPSKFWP DRFLEPG--- ---------- KNPRTPSFGC G--ARVCLGE Cyp24 NFEDADKFRP ERWLEKEK-- ---KIN---- -PFAHLPFGV G--KRMCIGR Cyp26a1 FTNKE-EFNP DRFIVPHPE- -----DAS-- -RFSFIPFGG G--LRSCVGK Cyp26b1 FKDVN-VFDP DRFSQARSE- -----DK--D GRFHYLPFGG G--VRTCLGK Cyp26c1 YRSPPEGFDP ERFGVESGD- -----ARGSG GRFHYIPFGG G--ARSCLGQ Cyp27a1 VFPEPNSFQP HRWLRKKE-- ---ADNPGIL HPFGSVPFGY G--VRSCLGR Cyp27b1 QFPDPNSFNP ARWLGEGP-- ---TP----- HPFASLPFGF G--KRSCIGR Cyp39 YFPEPESFKP ERWKEAN--- -----LDKYI FLDYFMAFGG G--KFQCPGR Cyp46 YFEDPLTFNP DRFGPG---- -------APK PRFTYFPFSL G--HRSCIGQ Cyp51 SWAERLDFNP DRYLQDN--- -----PAS-G EKFAYVPFGA G--RHRCVGE CYP1A1h LWVNPSEFLP ERFLTPDG-- -AIDKV---- LSEKVIIFGM G--KRKCIGE CYP1A2h LWEDPSEFRP ERFLTADGT- -AINKP---- LSEKMMLFGM G--KRRCIGE CYP1B1h KWPNPENFDP ARFLDKDG-- -LINKD---- LTSRVMIFSV G--KRRCIGE CYP2A6 FFSNPQDFNP QHFLNEKG-- ---QFK---- KSDAFVPFSI G--KRNCFGE CYP2A7 FFSNPRDFNP QHFLGEKG-- ---QFK---- KRDAFVPFSI R--KRNCFGE CYP2A13 FFSNPQDCSP QHFLDEKG-- ---QFK---- KSDAFVPFSI G--KRYCFGE CYP2B6 YFEKPDAFNP DHFLDANG-- ---ALK---- KTEAFIPFSL G--KRICLGE CYP2C8 EFPNPNIFDP GHFLDKNG-- ---NFK---- KSDYFMPFSA G--KRICAGE CYP2C9 EFPNPEMFDP HHFLDEGG-- ---NFK---- KSKYFMPFSA G--KRICVGE CYP2C18 EFPNPEMFDP GHFLDKSG-- ---NFK---- KSDYFMPFSA G--KRMCMGE CYP2C19 EFPNPEMFDP RHFLDEGG-- ---NFK---- KSNYFMPFSA G--KRICVGE CYP2D6 VWEKPFRFHP EHFLDAQG-- ---HFV---- KPEAFLPFSA G--RRACLGE CYP2E1h EFPDPEKFKP EHFLNENG-- ---KFK---- YSDYFKPFST G--KRVCAGE CYP2F1 QFLTPQEFNP EHFLDANQ-- ---SFK---- KSPAFMPFSA G--RRLCLGE CYP2G2P YFRYPDAFYP QHFLDEQG-- ---RFK---- KNEAFVPFSS GRGKRICLGE CYP2J2 EWATPDTFNP DHFLE-NG-- ---QFK---- KREAFMPFSI G--KRACLGE CYP2R1h YWRDPEVFHP ERFLDSSG-- ---YFA---- KKEALVPFSL G--RRHCLGE CYP2S1h IFKHPEEFNP DRFLDADG-- ---RFR---- KHEAFLPFSL G--KRVCLGE CYP2T2P QFKDPDCFNP TNFLDKG--- ---KFQ---- GNDAFMPFAP A--KQMCLGT CYP2U1h IWEKPEDFYP NRFLDDQG-- ---QLI---- KKETFIPFGI G--KRVCMGE CYP3A4 YWTEPEKFLP ERFSKKNK-- -------DNI DPYTYTPFGS G--PRNCIGM CYP3A5 YWTEPEEFRP ERFSKK-K-- -------DSI DPYIYTPFGT G--PRNCIGM CYP3A7 YWTEPEKFLP ERFSKKNK-- -------DNI DPYIYTPFGS G--PRNCIGM CYP3A43 YWTEPEKFCP ERFSKKNK-- -------DSI DLYRYIPFGA G--PRNCIGM CYP4A11 VWPNPEVFDP SRFAPG---- -------SAQ HSHAFLPFSG G--SRNCIGK CYP4A22 VWPNLEVFDP SRFAPG---- -------SAQ HSHAFLPFSG G--SRNCIGK CYP4B1h VWPDPEVFDS LRFSTENA-- -------SKR HPFAFMPFSA G--PRNCIGQ CYP4F2 VWPDPEVYDP FRFDPENI-- -------KER SPLAFIPFSA G--PRNCIGQ CYP4F3 VWPDPEVYDP FRFDPKNI-- -------KER SPLAFIPFSA G--PRNCIGQ CYP4F8 VWPDPEVYDP FRFDPENA-- -------QKR SPMAFIPFSA G--PRNCIGQ CYP4F11 VWPDPEVYDP FRFNQENI-- -------KER SPLAFIPFSA G--PRNCIGQ CYP4F12 VWPDPEVYDP FRFDPENS-- -------KGR SPLAFIPFSA G--PRNCIGQ CYP4F22 VWPDSKVYNP YRFDPDNP-- -------QQR SPLAYVPFSA G--PRNCIGQ CYP4F23P VWPDPEVYDP FRFDPENL-- -------QKT SPLAFIPFSA V--PRNCIGQ CYP4V2 YFPNPEEFQP ERFFPENA-- -------QGR HPYAYVPFSA G--PRNCIGQ CYP4X1h VWKNPKVFDP LRFSQENS-- -------DQR HPYAYLPFSA G--SRNCIGQ CYP4Z1 FWEDPQVFNP LRFSRENS-- -------EKI HPYAFIPFSA G--PRNCIGQ CYP5A1h HWPSPETFNP ERFTAEAR-- -------QQH RPFTYLPFGA G--PRSCLGV CYP7A1h IYPDPLTFKY DRYLDENGKT KTTFYCNGLK LKYYYMPFGS G--ATICPGR CYP7B1h IFEAPEEFRY DRFIED-GKK KTTFFKRGKK LKCYLMPFGT G--TSKCPGR CYP8A1h IYTDPEVFKY NRFLNPDGSE KKDFYKDGKR LKNYNMPWGA G--HNHCLGR CYP8B1h IHPEPTVFKY DRFLNPNGSR KVDFFKTGKK IHHYTMPWGS G--VSICPGR CYP11A1h FFFDPENFDP TRWLSKDK-- ---NI----- TYFRNLGFGW G--VRQCLGR CYP11B1h LFPRPERYNP QRWLDIRG-- ---SG----- RNFYHVPFGF G--MRQCLGR CYP11B2h LFPRPERYNP QRWLDIRG-- ---SG----- RNFHHVPFGF G--MRQCLGR CYP17h EWHQPDQFMP ERFLNPAG-- -TQLIS---- PSVSYLPFGA G--PRSCIGE CYP19h -FPKPNEFTL ENFAKNVP-- ---------- -YRYFQPFGF G--PRGCAGK CYP20h TWPSPHKFDP DRFDDE---- -------LVM KTFSSLGFSG ---TQECPEL CYP21A2h VWERPHEFWP DRFLEPG--- ---------- KNSRALAFGC G--ARVCLGE CYP24h NFEDSSQFRP ERWLQEKE-- ---KIN---- -PFAHLPFGV G--KRMCIGR CYP26A1h FTNKE-EFNP DRFMLPHPE- -----DAS-- -RFSFIPFGG G--LRSCVGK CYP26B1h FKDVN-VFDP DRFSQARSE- -----DK--D GRFHYLPFGG G--VRTCLGK CYP26C1h YRSPPEGFDP ERFGAARED- -----SRGAS SRLHYIPFGG G--ARSCLGQ CYP27A1h AFSEPESFQP HRWLRNSQ-- ---PATPRIQ HPFGSVPFGY G--VRACLGR CYP27B1h QFPEPNSFRP ARWLGEGP-- ---TP----- HPFASLPFGF G--KRSCMGR CYP27C1h NFPRAKEFRP ERWLRKGD-- ---LDR---V DNFGSIPFGH G--VRSCIGR CYP39A1h YFPEPELFKP ERWKKAN--- -----LEKHS FLDCFMAFGS G--KFQCPAR CYP46h YFEDPLTFNP DRFGPG---- -------APK PRFTYFPFSL G--HRSCIGQ CYP51h SWVERLDFNP DRYLQDN--- -----PAS-G EKFAYVPFGA G--RHRCIGE Cyp1a1 TIGRSEVFLF LAILLQQIEF KVSPG----E KVDMT----- ---------- Cyp1a2 IPAKWEVFLF LAILLQHLEF SVPPG----V KVDLT----- ---------- Cyp1b1 ELSKMLLFLF ISILAHQCNF KANQN----E SSNMS----- ---------- Cyp2a4 GLARMELFLF LTNIMQNFHF KSTQA---PQ DIDVS----- ---------- Cyp2a5 GLARMELFLF LTNIMQNFHF KSTQA---PQ DIDVS----- ---------- Cyp2a12 SLAKMELFFL FTTILQNFRF KFPRK---LE DINES----- ---------- Cyp2b9 SIARNELFIF FTTILQNFSV ASPVA---PK DIDLT----- ---------- Cyp2b10 SIARNELFLF FTSILQNFSV ASHVA---PK DIDLT----- ---------- Cyp2b13 SIARNELFLF FTSILQNFSV ASPVA---SK DIDLT----- ---------- Cyp2b19 GIARNELFLF FTTILQNFSL ASPVA---PE NIDLI----- ---------- Cyp2b23 GIARNELFLF FTALLQNFSL SSPVA---PE DIDLT----- ---------- Cyp2c29 GLARMELFLI LTTILQNFKL KSLVH---PK EIDIT----- ---------- Cyp2c37 GLARMELFLF LTSILQSFNL KPLVH---PK DIDVT----- ---------- Cyp2c38 GLARMELFLI LTTILQNFKL KSLVH---PK DIDMM----- ---------- Cyp2c39 GLARMELFLF LTTILQNFKL KPLVH---PK DIDMI----- ---------- Cyp2c40 SLARMELFLF LTTILQNFKL KPLVD---PK DIDMT----- ---------- Cyp2c44 GLARMELFLF FTTILQKFSL KALVE---PK DLDIK----- ---------- Cyp2c50 GLARMELFLF LTSILQNFNL KPLVH---PK DIDVT----- ---------- Cyp2c54 GLARMELFLF LTSILQNFNL KPLVH---PK DIDIT----- ---------- Cyp2c55 ALARTELFLI LTTILQNFNL KSLVD---TK DIDTT----- ---------- Cyp2c65 GLARAELFLF LTTILQNFNL KSPVD---LK DLDTT----- ---------- Cyp2c66 GLARTELFLF LTTILQNFNL KSPVD---LK DLDTT----- ---------- Cyp2c67 SLARMELFLF LTTILQNFKL KPLVD---PK DIDMT----- ---------- Cyp2c68 ---------- ---------- ---------- ---------- ---------- Cyp2c69 SLARMELFLF LTTILQNFKL KPLVD---PK DIDTT----- ---------- Cyp2c70 GLARMEMFLI LTNILQHFTL KPLVK---PE DIDTK----- ---------- Cyp2d9 ALARMELFLF FTCLLQRFSF SVPDG---QP QPSNS----- ---------- Cyp2d10 PLARMELFLF FTCLLQHFSF SVPNG---QP RPRNL----- ---------- Cyp2d11 ALARMELFLF FTCLLQRFSI SVPDG---QP QPSNY----- ---------- Cyp2d12 PLARMELFLF FTCLLQRFSF SVPDG---QP QPSDH----- ---------- Cyp2d13 PLARMELFLF FTCLLQRFSF LVPAG---QP QPSDY----- ---------- Cyp2d22 PLARMELFLF FTCLLQRFSI SVPDG---QP QPSDH----- ---------- Cyp2d26 PLARMELFLF FTCLLQRFSF SVPDG---QP RPSDY----- ---------- Cyp2e1 GLARMELFLL LSAILQHFNL KSLVD---PK DIDLS----- ---------- Cyp2f2 PLARMELFIY FTSILQNFTL QPLVD---PE DIDLT----- ---------- Cyp2g1 ALARMELFLY FTSILQRFSL RSLVP---PA DIDIA----- ---------- Cyp2j5 QLAKSELFIF FSALMQKFTF KPPIN----E KLSLK----- ---------- Cyp2j6 QLARSELFIF FTSLMQKFTF NPPIN----E KLSPK----- ---------- Cyp2j7 QLARTELFIF FTALMQKFTF KAPVN----E KLSLK----- ---------- Cyp2j8 QLARSELFTF FTALMQKFTF KPPIN----E KLSLN----- ---------- Cyp2j9 QLARSELFIF ITTLFQKFTF KPPVN----E KLSLQ----- ---------- Cyp2j13 QLARSELFIF FTALVQKFTF KPPAN----E NLSLK----- ---------- Cyp2j12 QLARSELFIF FTALMQKFTF KPPIN----E KLSLK----- ---------- cyp2j11 QLASCELFIF FTALMQKFTF KSPIN----E KPSLK----- ---------- Cyp2r1 QLARMEMFLF FTSLLQQFHL HFPHE----L VPNLK----- ---------- Cyp2s1 GLARAELWLF FTSILQAFSL ETPCP---PG DLSLK----- ---------- Cyp2t4 GLARSEIFLF LTAILQKFSL LPVGS---PA NINLN----- ---------- Cyp2U1 ---------- ---------- ---------- ---------- ---------- Cyp2w1 SLARTELFLL FAGLLQRYRL LPPPG---LS PADLDLR--- ---------- CYP2W1h RLARTELFLL FAGLLQRYRL LPPPG---VS PASLDTT--- ---------- Cyp3a11 RFALMNMKLA LTKIMQNFSF QPCKE---TQ IPLKLSR--- ---------- Cyp3a13 RFALINMKVA LVRVLQNFTV QPCKE---TE IPLKLSK--- ---------- Cyp3a16 RFALMNMKLA LIKVLQNFSF QPCKE---TQ IPLKLSR--- ---------- Cyp3a25 RFALISIKLA VIGVLQNFTV QPCEE---TQ IPLKISR--- ---------- Cyp3a57 RFALISVKLA VTGVLQNFTV QPCEE---TQ IPVKISR--- ---------- Cyp3a41 RFAFMTMKLA LTKVMQNFSF QPCQE---TQ IPLKLSR--- ---------- Cyp3a44 RFALMNMKLA VTKVLQNFSF QPCQE---TQ IPLKLSR--- ---------- Cyp4a10 QFAMSELKVI VALTLLRFEL LPDPT---RV PMPLA----- ---------- Cyp4a12 QFAMNELKVA VALTLLRFEL LPDPT---RV PIPIP----- ---------- Cyp4a14 QFAMNELKVA VALTLLRFEL LPDPT---RI PVPIA----- ---------- Cyp4a30 QFTMNELKVA VALTLLRFEL LPDPT---RV PILVS----- ---------- Cyp4a29 HLAMNVLKVA VALTLLRFEL LPDPS---RV PIPTQ----- ---------- Cyp4b1 QFAMNEMKVV TALCLLRFEF SPDPS---KI PIKVP----- ---------- Cyp4f13 TFAMSEIKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- Cyp4f14 TFAMSEMKVA LALTLLRFRL LPD-D---KE PRRQP----- ---------- Cyp4f15 TFAMNEMKVA LALTLLRFRV LPD-D---KE PRRKP----- ---------- Cyp4f16 TFAMSEMKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- Cyp4f17 TFAMREMKVA LALTLLRFRV LPG-D---KE PRRKP----- ---------- Cyp4f18 TFAMSEMKVA LALTLLRFRV LPD-D---KE PRRKP----- ---------- Cyp4f37 TFAMNEMMVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- Cyp4f39 SFAMAEMRVV VALTLLRFRL SVDRT---HK VRRKP----- ---------- Cyp4f40 TFAMSEMKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- Cyp4v3 KFAVMEEKTI LACILRQFWV ESNQK---RE ELGLAG---- ---------- Cyp4x1 QFAMLELKVA IALILLHFQV APDLT---RP PAFSS----- ---------- Cyp5a1 RLGLLVVKLT ILQVLHKFRF EASPE---TQ VPLQLES--- ---------- Cyp7a1 LFAVQEIKQF LILMLSYFEL ELVESHTKCP PLDQS----- ---------- Cyp7b1 YFAVNEMKLL LIELLTYFDL EIID--RKPI GLNHS----- ---------- Cyp8a1 SYAINSIKQF VVLLLTHFDL ELGSEDTEVP EFDLS----- ---------- Cyp8b1 FFALSEMKTF VLLMIMYFDF KLVDPDIPVP PIDPR----- ---------- Cyp11a1 RIAELEMTIL LINLLENFRI EVQN----LR DVGTK----- ---------- Cyp11b1 RLAEAEMMLL LHHVLKSFHV ETQE----KE DVRMA----- ---------- Cyp11b2 RLAEVEMMLL LHHILKTFQV ETLR----QE DVQMA----- ---------- Cyp17 ALARQELFIF MALLLQRFDF DVSDD---KQ LPCLV----- ---------- Cyp19 YIAMVMMKVV LVTLLRRFQV KTLQK---RC IENIP----- ---------- Cyp20 XFAYMVTAVL VSVLLEKLRL LAVDR---QV VEMKY----- ---------- Cyp21 PLARLELFVV LARLLQAFTL LPPPD---GT LPSLQ----- ---------- Cyp24 RLAELQLHLA LCWIIQKYNI VATD----SE PVEML----- ---------- Cyp26a1 EFAKILLKIF TVELARHCDW QLLN---GPP TMKTS----- ---------- Cyp26b1 HLAKLFLKVL AVELASTSRF ELATR--TFP RITLV----- ---------- Cyp26c1 ELAQAVLQLL AVELVRTARW ELATP--AFP VMQTV----- ---------- Cyp27a1 RIAELEMQLM LSRLVQKYEI ALAPG---MG EVKTV----- ---------- Cyp27b1 RLAELELQMA LSQILTHFEV LPEPG---AL PIKPM----- ---------- Cyp39 WFALLEIQLC IILVLYKYEC SLLDP--LPK QS--S----- ---------- Cyp46 QFAQMEVKVV MAKLLQRIEF RLVPG---QR FGLQE----- ---------- Cyp51 NFAYVQIKTI WSTMLRLYEF DLING--YFP TVN------- ---------- CYP1A1h TIARWEVFLF LAILLQRVEF SVPLG----V KVDMT----- ---------- CYP1A2h VLAKWEIFLF LAILLQQLEF SVPPG----V KVDLT----- ---------- CYP1B1h ELSKMQLFLF ISILAHQCDF RANPN----E PAKMN----- ---------- CYP2A6 GLARMELFLF FTTVMQNFRL KSSQS---PK DIDVS----- ---------- CYP2A7 GLARMELFLF FTTVMQNFRL KSSQS---PK DIDVS----- ---------- CYP2A13 GLARMELFLF FTTIMQNFRF KSPQS---PK DIDVS----- ---------- CYP2B6 GIARAELFLF FTTILQNFSM ASPVA---PE DIDLT----- ---------- CYP2C8 GLARMELFLF LTTILQNFNL KSVDD---LK NLNTT----- ---------- CYP2C9 ALAGMELFLF LTSILQNFNL KSLVD---PK NLDTT----- ---------- CYP2C18 GLARMELFLF LTTILQNFNL KSQVD---PK DIDIT----- ---------- CYP2C19 GLARMELFLF LTFILQNFNL KSLID---PK DLDTT----- ---------- CYP2D6 PLARMELFLF FTSLLQHFSF SVPTG---QP RPSHH----- ---------- CYP2E1h GLARMELFLL LCAILQHFNL KPLVD---PK DIDLS----- ---------- CYP2F1 LLARMELFLY LTAILQSFSL QPLGA---PE DIDLT----- ---------- CYP2G2P AMDRMELFLY FTSTLQNFSL HSLVP---PV DIDIT----- ---------- CYP2J2 QLARTELFIF FTSLMQKFTF RPPNN----E KLSLK----- ---------- CYP2R1h HLARMEMFLF FTALLQRFHL HFPHE----L VPDLK----- ---------- CYP2S1h GLAKAEVFLF FTTILQAFSL ESPCP---PD TLSLK----- ---------- CYP2T2P GLAHSGIFLF LTATLQRFCL LPVVR---PG TINLT----- ---------- CYP2U1h QLAKMELFLM FVSLMQSFAF ALPED---SK KPLLT----- ---------- CYP3A4 RFALMNMKLA LIRVLQNFSF KPCKE---TQ IPLKLSL--- ---------- CYP3A5 RFALMNMKLA LIRVLQNFSF KPCKE---TQ IPLKLDT--- ---------- CYP3A7 RFALVNMKLA LVRVLQNFSF KPCKE---TQ IPLKLRF--- ---------- CYP3A43 RFALTNIKLA VIRALQNFSF KPCKE---TQ IPLKLDN--- ---------- CYP4A11 QFAMNELKVA TALTLLRFEL LPDPT---RI PIPIA----- ---------- CYP4A22 QFAMNQLKVA RALTLLRFEL LPDPT---RI PIPMA----- ---------- CYP4B1h QFAMSEMKVV TAMCLLRFEF SLDPS---RL PIKMP----- ---------- CYP4F2 TFAMAEMKVV LALTLLAFRV LPD-H---TE PRRKP----- ---------- CYP4F3 AFAMAEMKVV LGLTLLAFRV LPD-H---TE PRRKP----- ---------- CYP4F8 KFAMAEMKVV LALTLLRFRI LPD-H---RE PRRTP----- ---------- CYP4F11 AFAMAEMKVV LALTLLHFRI LPT-H---IE PRRKP----- ---------- CYP4F12 AFAMAEMKVV LALMLLHFRF LPD-H---TE PRRKL----- ---------- CYP4F22 SFAMAELRVV VALTLLRFRL SVDRT---RK VRRKP----- ---------- CYP4F23P TFAMAEMKVV LALTLLRFRV LPD-H---AE PRRKL----- ---------- CYP4V2 KFAVMEEKTI LSCILRHFWI ESNQK---RE ELGLEG---- ---------- CYP4X1h EFAMIELKVT IALILLHFRV TPDPT---RP LTFPN----- ---------- CYP4Z1 HFAIIECKVA VALTLLRFKL APDHS---RP PQPVR----- ---------- CYP5A1h RLGLLEVKLT LLHVLHKFRF QACPE---TQ VPLQLES--- ---------- CYP7A1h LFAIHEIKQF LILMLSYFEL ELIEGQAKCP PLDQS----- ---------- CYP7B1h FFALMEIKQL LVILLTYFDL EIID--DKPI GLNYS----- ---------- CYP8A1h SYAVNSIKQF VFLVLVHLDL ELINADVEIP EFDLS----- ---------- CYP8B1h FFALSEVKLF ILLMVTHFDL ELVDPDTPLP HVDPQ----- ---------- CYP11A1h RIAELEMTIF LINMLENFRV EIQH----LS DVGTT----- ---------- CYP11B1h RLAEAEMLLL LHHVLKHLQV ETLT----QE DIKMV----- ---------- CYP11B2h RLAEAEMLLL LHHVLKHFLV ETLT----QE DIKMV----- ---------- CYP17h ILARQELFLI MAWLLQRFDL EVPDD---GQ LPSLE----- ---------- CYP19h YIAMVMMKAI LVTLLRRFHV KTLQG---QC VESIQ----- ---------- CYP20h RFAYMVTTVL LSVLVKRLHL LSVEG---QV IETKY----- ---------- CYP21A2h PLARLELFVV LTRLLQAFTL LPSGD----A LPSLQ----- ---------- CYP24h RLAELQLHLA LCWIVRKYDI QATD----NE PVEML----- ---------- CYP26A1h EFAKILLKIF TVELARHCDW QLLN---GPP TMKTS----- ---------- CYP26B1h HLAKLFLKVL AVELASTSRF ELATR--TFP RITLV----- ---------- CYP26C1h ELAQAVLQLL AVELVRTARW ELATP--AFP AMQTV----- ---------- CYP27A1h RIAELEMQLL LARLIQKYKV VLAPE---TG ELKSV----- ---------- CYP27B1h RLAELELQMA LAQILTHFEV QPEPG---AA PVRPK----- ---------- CYP27C1h RIAELEIHLV VIQLLQHFEI KTSSQ---TN AVHAK----- ---------- CYP39A1h WFALLEVQMC IILILYKYDC SLLDP--LPK QS--Y----- ---------- CYP46h QFAQMEVKVV MAKLLQRLEF RLVPG---QR FGLQE----- ---------- CYP51h NFAYVQIKTI WSTMLRLYEF DLIDG--YFP TVN------- ---------- Cyp1a1 ---------- ---------- -----PTYGL TLKHARCEHF QVQMRSSGPQ Cyp1a2 ---------- ---------- -----PNYGL TMKPGTCEHV QAWPRFSK-- Cyp1b1 ---------- ---------- -----FSYGL TIKPKSFRIH VSLRESMELL Cyp2a4 ---------- ---------- ----PRLVGF VTIPPTYTMS FLSR------ Cyp2a5 ---------- ---------- ----PRLVGF ATIPPTYTMS FLSR------ Cyp2a12 ---------- ---------- ----PTPEGF TRIIPKYTMS FVPI------ Cyp2b9 ---------- ---------- ----PKESGI GKIPPAHQIY FLAR------ Cyp2b10 ---------- ---------- ----PKESGI GKIPPTYQIC FLAR------ Cyp2b13 ---------- ---------- ----PKESGI GKIPPTYQIC FLAR------ Cyp2b19 ---------- ---------- ----PNNSGA TKTPPQYQIH FLSR------ Cyp2b23 ---------- ---------- ----PKESGF VKIPPVYRIC FLPR------ Cyp2c29 ---------- ---------- ----PVMNGF ASLPPPYQLC FIPL------ Cyp2c37 ---------- ---------- ----PMLIGL GSVPPAFQLC FIPS------ Cyp2c38 ---------- ---------- ----PFVNGL IALPPHYQLC FIPL------ Cyp2c39 ---------- ---------- ----PFVNGL IALPPHYQVC IIPR------ Cyp2c40 ---------- ---------- ----PKHSGF SKIPPNFQMC FIPVE----- Cyp2c44 ---------- ---------- ----PVTTGL FNLPPPYKLR LVPR------ Cyp2c50 ---------- ---------- ----PMLIGL ASVPPAFQLC FIPS------ Cyp2c54 ---------- ---------- ----PMLIGL GSVPPAFQLC FIPS------ Cyp2c55 ---------- ---------- ----PVANTF GRVPPSYQLY FIPR------ Cyp2c65 ---------- ---------- ----PVANGF ASVPPKFQIC FIPI------ Cyp2c66 ---------- ---------- ----PVANGF VSVPPKFQIC FISI------ Cyp2c67 ---------- ---------- ----PKHSGF SKIPPNFQMC FIPVE----- Cyp2c68 ---------- ---------- ---------- ---------- ---------- Cyp2c69 ---------- ---------- ----PKYSGF SKIPPKFQMC FIPVE----- Cyp2c70 ---------- ---------- ----PVQTGL LHVPPPFELC FIPV------ Cyp2d9 ---------- ---------- -----GVYGI LVAPSPYQLC AVVRDQGH-- Cyp2d10 ---------- ---------- -----GVFPF PVAPYPYQLC AVMREQGH-- Cyp2d11 ---------- ---------- -----RVHAI PVAPFPYQLC AVMHEQGH-- Cyp2d12 ---------- ---------- -----RVFFI MVAPSPYQLC AVIREQGH-- Cyp2d13 ---------- ---------- -----GIFTF LVSPSPYQLC AFTRDQATN- Cyp2d22 ---------- ---------- -----GVFRA LTTPCPYQLC ALPR------ Cyp2d26 ---------- ---------- -----GIYTM PVTPEPYQLC AVAR------ Cyp2e1 ---------- ---------- ----PVTIGF GSIPREFKLC VIPRS----- Cyp2f2 ---------- ---------- ----PLSSGL GNLPRPFQLC MHIR------ Cyp2g1 ---------- ---------- ----HKISGF GNIPPVYELC FMAR------ Cyp2j5 ---------- ---------- -----FRMGL ILSPASYRIC AIPRV----- Cyp2j6 ---------- ---------- -----FRNGL TLSPVSHRIC AVPRQ----- Cyp2j7 ---------- ---------- -----FRMSV PISPVSYCIC AVPRQ----- Cyp2j8 ---------- ---------- -----FKMGV ALSPVSYCIC AVPR------ Cyp2j9 ---------- ---------- -----FRMAA TVSPVSHRLC AIPRL----- Cyp2j13 ---------- ---------- -----FRLGI TISPVSYRIG AVPRQ----- Cyp2j12 ---------- ---------- -----FRNGL TLSPVSHCIC AVPRH----- cyp2j11 ---------- ---------- -----FRMGL TLAPVSYRIC AVPRL----- Cyp2r1 ---------- ---------- -----PRLGM TLQPQPYLIC AERR------ Cyp2s1 ---------- ---------- ----PAISGL FNIPPDFQLR VWPTGDQSR- Cyp2t4 ---------- ---------- ----PQCTGL GNVPPAFQLR LVAR------ Cyp2U1 ---------- ---------- ---------- ---------- ---------- Cyp2w1 ---------- ---------- -----PAPAF TMRPPAQ--- ---------- CYP2W1h ---------- ---------- -----PARAF TMRPRAQALC AVPRP----- Cyp3a11 ---------- ---------- -------QGL LQPEKPIVLK VVPRDAVITG Cyp3a13 ---------- ---------- -------QGL LQPENPLLLK VVSRDETVSD Cyp3a16 ---------- ---------- -------ELL LQPVKPIVLK VVPRDAVITG Cyp3a25 ---------- ---------- -------EPI FQPEKPIILK VVSRDKPRTG Cyp3a57 ---------- ---------- -------QPI FRPEKPIILK FVSRDKPRTG Cyp3a41 ---------- ---------- -------QGL LQPEKPIVLK VVPRDVVITG Cyp3a44 ---------- ---------- -------QGI LQPEKPIVLK VVPRDAVITG Cyp4a10 ---------- ---------- -------RLV LKSKNGIYLH LKKLH----- Cyp4a12 ---------- ---------- -------RIV LKSKNGIHLH LKKLQ----- Cyp4a14 ---------- ---------- -------RLV LKSKNGIHLC LKKLR----- Cyp4a30 ---------- ---------- -------KIV LKSKNGIYLH TKKL------ Cyp4a29 ---------- ---------- -------QLV LKSKNGIYLH LRKL------ Cyp4b1 ---------- ---------- -------QLI LRSKNGIHLY LKPLGPGSGK Cyp4f13 ---------- ---------- -------ELI LRAEGGLWLR VEPLSAGAQ- Cyp4f14 ---------- ---------- -------ELI LRAEGGLWLR VEPLSAGAH- Cyp4f15 ---------- ---------- -------ELI LRAEGGLWLR VEPLSTQ--- Cyp4f16 ---------- ---------- -------EII LRAEGGLWLR VEPLSKGAQ- Cyp4f17 ---------- ---------- -------ELI LRAEGGLWLR VEPLSKGTQ- Cyp4f18 ---------- ---------- -------ELI LRAEGGLWLK VEPLSAGAQ- Cyp4f37 ---------- ---------- -------EII LRAEGGLWLR VEPLS----- Cyp4f39 ---------- ---------- -------ELI LRTENGLWLN VEPLPSRA-- Cyp4f40 ---------- ---------- -------ELI LRAEGGLWLR VEPLSTQA-- Cyp4v3 ---------- ---------- -------DLI LRPNNGIWIK LKRRHEDDP- Cyp4x1 ---------- ---------- -------HTV LRPKHGIYLH LKKL------ Cyp5a1 ---------- ---------- -------KSA LGPKNGVYIK IVSR------ Cyp7a1 ---------- ---------- ----RAGLGI LPPLNDIEFK YKLKH----- Cyp7b1 ---------- ---------- ----RMFLGI QHPDSAVSFR YKAKSWRS-- Cyp8a1 ---------- ---------- ----RYGFGL MQPEEDVPIR YRARL----- Cyp8b1 ---------- ---------- ----RWGFGT SQPSHEVRFL YRLKPVQ--- Cyp11a1 ---------- ---------- ------FSLI LMPENPILFN FQPLKQDLGP Cyp11b1 ---------- ---------- ------YRFV LMPSSSPLLT FRPVN----- Cyp11b2 ---------- ---------- ------YRFV LMPSSSPVLT FRPVS----- Cyp17 ----G----- ---------- ----DPKVVF LIDPFKVKIT VRQAWKDAQV Cyp19 ---------- ----K-KN-- ----DLSLHP NEDRHLVEII FSPRNSDKYL Cyp20 ---------- ---------- -------ELV TSAREEAWIT VSKRH----- Cyp21 ----P----- ---------- ----QPYAGI NLPIPPFQVR LQPRNLAPQD Cyp24 ---------- ---------- ------HLGI LVPSRELPIA FCPR------ Cyp26a1 ---------- ---------- ----PTVYPV DNLPARFTYF QGDI------ Cyp26b1 ---------- ---------- ----PVLHPV DGLSVKFFGL DSNQNEILPE Cyp26c1 ---------- ---------- ----PIVHPV DGLLLFFHPL PTSGAGDGLP Cyp27a1 ---------- ---------- ------SRIV LVPSKKVRLH FLQRQ----- Cyp27b1 ---------- ---------- ------TRTV LVPERSINLQ FVDR------ Cyp39 ---------- ---------- ----RHLVGV PQPAGKCRIE YKQRA----- Cyp46 ---------- ---------- -------QAT LKPLDPVLCT LRPRGWQPAP Cyp51 ---------- ---------- -----YTTMI HTPENPVIRY KRRSK----- CYP1A1h ---------- ---------- -----PIYGL TMKHACCEHF QMQLRS---- CYP1A2h ---------- ---------- -----PIYGL TMKHARCEHV QARRFSIN-- CYP1B1h ---------- ---------- -----FSYGL TIKPKSFKVN VTLRESMELL CYP2A6 ---------- ---------- ----PKHVGF ATIPRNYTMS FLPR------ CYP2A7 ---------- ---------- ----PKHVVF ATIPRNYTMS FLPR------ CYP2A13 ---------- ---------- ----PKHVGF ATIPRNYTMS FLPR------ CYP2B6 ---------- ---------- ----PQECGV GKIPPTYQIR FLPR------ CYP2C8 ---------- ---------- ----AVTKGI VSLPPSYQIC FIPV------ CYP2C9 ---------- ---------- ----PVVNGF ASVPPFYQLC FIPV------ CYP2C18 ---------- ---------- ----PIANAF GRVPPLYQLC FIPV------ CYP2C19 ---------- ---------- ----PVVNGF ASVPPFYQLC FIPV------ CYP2D6 ---------- ---------- -----GVFAF LVSPSPYELC AVPR------ CYP2E1h ---------- ---------- ----PIHIGF GCIPPRYKLC VIPRS----- CYP2F1 ---------- ---------- ----PLSSGL GNLPRPFQLC LRPR------ CYP2G2P ---------- ---------- ----PKLSGF GNIPPTYELC LVAR------ CYP2J2 ---------- ---------- -----FRMGI TISPVSHRLC ---------- CYP2R1h ---------- ---------- -----PRLGM TLQPQPYLIC AERR------ CYP2S1h ---------- ---------- ----PTVSGL FNIPPAFQLQ VRPTDLHSTT CYP2T2P ---------- ---------- -----QCTGL GSVPPDFQLQ PVAC------ CYP2U1h ---------- ---------- -----GRFGL TLAPHPFNIT ISRR------ CYP3A4 ---------- ---------- -------GGL LQPEKPVVLK VESRDGTVSG CYP3A5 ---------- ---------- -------QGL LQPEKPIVLK VDSRDGTLSG CYP3A7 ---------- ---------- -------GGL LLTEKPIVLK AESRDETVSG CYP3A43 ---------- ---------- -------LPI LQPEKPIVLK VHLRDGITSG CYP4A11 ---------- ---------- -------RLV LKSKNGIHLR LRRLPNPCED CYP4A22 ---------- ---------- -------RLV LKSKNGIHLR LRRLPNPCED CYP4B1h ---------- ---------- -------QLV LRSKNGFHLH LKPLGPGSGK CYP4F2 ---------- ---------- -------ELV LRAEGGLWLR VEPLS----- CYP4F3 ---------- ---------- -------ELV LRAEGGLWLR VEPLS----- CYP4F8 ---------- ---------- -------EIV LRAEDGLWLR VEPLG----- CYP4F11 ---------- ---------- -------ELI LRAEGGLWLR VEPLGANSQ- CYP4F12 ---------- ---------- -------ELI MRAEGGLWLR VEPLNVGLQ- CYP4F22 ---------- ---------- -------ELI LRTENGLWLK VEPLPPRA-- CYP4F23P ---------- ---------- -------ELI VRAEDGLWLR VEPLSADLQ- CYP4V2 ---------- ---------- -------QLI LRPSNGIWIK LKRRNADER- CYP4X1h ---------- ---------- -------HFI LKPKNGMYLH LKKL------ CYP4Z1 ---------- ---------- -------QVV LKSKNGIHVF AKKV------ CYP5A1h ---------- ---------- -------KSA LGPKNGVYIK IVSR------ CYP7A1h ---------- ---------- ----RAGLGI LPPLNDIEFK YKFKHL---- CYP7B1h ---------- ---------- ----RLLFGI QYPDSDVLFR YKVKS----- CYP8A1h ---------- ---------- ----RYGFGL MQPEHDVPVR YRIRP----- CYP8B1h ---------- ---------- ----RWGFGT MQPSHDVRFR YRLHPTE--- CYP11A1h ---------- ---------- ------FNLI LMPEKPISFT FWPFNQEATQ CYP11B1h ---------- ---------- ------YSFI LRPSMCPLLT FRAIN----- CYP11B2h ---------- ---------- ------YSFI LRPGTSPLLT FRAIN----- CYP17h ----G----- ---------- ----IPKVVF LIDSFKVKIK VRQAWREAQA CYP19h ---------- ----K-IH-- ----DLSLHP DETKNMLEMI FTPRNSDRCL CYP20h ---------- ---------- -------ELV TSSREEAWIT VSKRY----- CYP21A2h ----P----- ---------- ----LPHCSV ILKMQPFQVR LQPRGMGAHS CYP24h ---------- ---------- ------HSGT LVPSRELPIA FCQR------ CYP26A1h ---------- ---------- ----PTVYPV DNLPARFTHF HGEI------ CYP26B1h ---------- ---------- ----PVLHPV DGLSVKFFGL DSNQNEILPE CYP26C1h ---------- ---------- ----PIVHPV DGLRLFFHPL TPSVAGNGLC CYP27A1h ---------- ---------- ------ARIV LVPNKKVGLQ FLQRQC---- CYP27B1h ---------- ---------- ------TRTV LVPERSINLQ FLDR------ CYP27C1h ---------- ---------- ------THGL LTPGGPIHVR FVNRK----- CYP39A1h ---------- ---------- ----LHLVGV PQPEGQCRIE YKQRI----- CYP46h ---------- ---------- -------QAT LKPLDPVLCT LRPRGWQPAP CYP51h ---------- ---------- -----YTTMI HTPENPVIRY KRRSK----- Cyp1a1 HLQA------ ---- Cyp1a2 ---------- ---- Cyp1b1 DNAVKKLQTE EGCK Cyp2a4 ---------- ---- Cyp2a5 ---------- ---- Cyp2a12 ---------- ---- Cyp2b9 ---------- ---- Cyp2b10 ---------- ---- Cyp2b13 ---------- ---- Cyp2b19 ---------- ---- Cyp2b23 ---------- ---- Cyp2c29 ---------- ---- Cyp2c37 ---------- ---- Cyp2c38 ---------- ---- Cyp2c39 ---------- ---- Cyp2c40 ---------- ---- Cyp2c44 ---------- ---- Cyp2c50 ---------- ---- Cyp2c54 ---------- ---- Cyp2c55 ---------- ---- Cyp2c65 ---------- ---- Cyp2c66 ---------- ---- Cyp2c67 ---------- ---- Cyp2c68 ---------- ---- Cyp2c69 ---------- ---- Cyp2c70 ---------- ---- Cyp2d9 ---------- ---- Cyp2d10 ---------- ---- Cyp2d11 ---------- ---- Cyp2d12 ---------- ---- Cyp2d13 ---------- ---- Cyp2d22 ---------- ---- Cyp2d26 ---------- ---- Cyp2e1 ---------- ---- Cyp2f2 ---------- ---- Cyp2g1 ---------- ---- Cyp2j5 ---------- ---- Cyp2j6 ---------- ---- Cyp2j7 ---------- ---- Cyp2j8 ---------- ---- Cyp2j9 ---------- ---- Cyp2j13 ---------- ---- Cyp2j12 ---------- ---- cyp2j11 ---------- ---- Cyp2r1 ---------- ---- Cyp2s1 ---------- ---- Cyp2t4 ---------- ---- Cyp2U1 ---------- ---- Cyp2w1 ---------- ---- CYP2W1h ---------- ---- Cyp3a11 A--------- ---- Cyp3a13 E--------- ---- Cyp3a16 A--------- ---- Cyp3a25 S--------- ---- Cyp3a57 P--------- ---- Cyp3a41 A--------- ---- Cyp3a44 A--------- ---- Cyp4a10 ---------- ---- Cyp4a12 ---------- ---- Cyp4a14 ---------- ---- Cyp4a30 ---------- ---- Cyp4a29 ---------- ---- Cyp4b1 ---------- ---- Cyp4f13 ---------- ---- Cyp4f14 ---------- ---- Cyp4f15 ---------- ---- Cyp4f16 ---------- ---- Cyp4f17 ---------- ---- Cyp4f18 ---------- ---- Cyp4f37 ---------- ---- Cyp4f39 ---------- ---- Cyp4f40 ---------- ---- Cyp4v3 ---------- ---- Cyp4x1 ---------- ---- Cyp5a1 ---------- ---- Cyp7a1 ---------- ---- Cyp7b1 ---------- ---- Cyp8a1 ---------- ---- Cyp8b1 ---------- ---- Cyp11a1 AVTRKDNTVN ---- Cyp11b1 ---------- ---- Cyp11b2 ---------- ---- Cyp17 EVST------ ---- Cyp19 QQ-------- ---- Cyp20 ---------- ---- Cyp21 QGERP----- ---- Cyp24 ---------- ---- Cyp26a1 ---------- ---- Cyp26b1 TEAMLSATV- ---- Cyp26c1 F--------- ---- Cyp27a1 ---------- ---- Cyp27b1 ---------- ---- Cyp39 ---------- ---- Cyp46 PPPPC----- ---- Cyp51 ---------- ---- CYP1A1h ---------- ---- CYP1A2h ---------- ---- CYP1B1h DSAVQNLQAK ETCQ CYP2A6 ---------- ---- CYP2A7 ---------- ---- CYP2A13 ---------- ---- CYP2B6 ---------- ---- CYP2C8 ---------- ---- CYP2C9 ---------- ---- CYP2C18 ---------- ---- CYP2C19 ---------- ---- CYP2D6 ---------- ---- CYP2E1h ---------- ---- CYP2F1 ---------- ---- CYP2G2P ---------- ---- CYP2J2 ---------- ---- CYP2R1h ---------- ---- CYP2S1h QTR------- ---- CYP2T2P ---------- ---- CYP2U1h ---------- ---- CYP3A4 A--------- ---- CYP3A5 E--------- ---- CYP3A7 A--------- ---- CYP3A43 P--------- ---- CYP4A11 KDQL------ ---- CYP4A22 KDQL------ ---- CYP4B1h ---------- ---- CYP4F2 ---------- ---- 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