163    814
Cyp1a1     ---------- ---------- ---------M PSMYGLPAFV SATELLLAVT 
Cyp1a2     ---------- ---------- ---------- --MAFSQYIS LAPELLLATA 
Cyp1b1     ---------- ---------- --MATSLSAD SPQQLSSLST QQTTLLLLFS 
Cyp2a4     ---------- ---------- ---------- ----MLTSGL LLVAAVAFLS 
Cyp2a5     ---------- ---------- ---------- ----MLTSGL LLVAAVAFLS 
Cyp2a12    ---------- ---------- ---------- ----MLGSGL LLLAILAFLS 
Cyp2a22    ---------- ---------- ---------- ----MLGSGL LLVAILVFLS 
Cyp2b9     ---------- ---------- ---------- ------MDPS VLLLLAVLLS 
Cyp2b10    ---------- ---------- ---------- ------MEPS VLLLLALLVG 
Cyp2b13    ---------- ---------- ---------- ------MDPS VLLLLAVLLS 
Cyp2b19    ---------- ---------- ---------- ------MEFS VLLLLALTTG 
Cyp2b23    ---------- ---------- ---------- ------MEPS VLLLLALLTG 
Cyp2c29    ---------- ---------- ---------- --------MD LVVFLALTLS 
Cyp2c37    ---------- ---------- ---------- --------MD PILVLVLTLS 
Cyp2c38    ---------- ---------- ---------- ---------D LVTFLVLTLS 
Cyp2c39    ---------- ---------- ---------- ---------D LVTFLVLTLS 
Cyp2c40    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c44    ---------- ---------- ---------- ----MELLGL PTLALLVLVM 
Cyp2c50    ---------- ---------- ---------- --------MD PILVLVFTLS 
Cyp2c54    ---------- ---------- ---------- --------MD PILVLVLTLS 
Cyp2c55    ---------- ---------- ---------- --------MD PVLVLVLTLS 
Cyp2c65    ---------- ---------- ---------- --------MV LGVFLGLLLT 
Cyp2c66    ---------- ---------- ---------- --------MV LGVFLGLLLT 
Cyp2c67    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c68    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c69    ---------- ---------- ---------- --------MD PFVVLVLCLS 
Cyp2c70    ---------- ---------- ---------- -----SESMA LFIFLGIWLS 
Cyp2ac1    ---------- ---------- ---------- ----MSGFDF SAMLALLGLS 
Cyp2ab1    ---------- ---------- ---------- ------MFSL FSGMAFLAGS 
Cyp2d9     ---------- ---------- ---------- ------MELL TGTDLWPVA- 
Cyp2d10    ---------- ---------- ---------- ------MELL TGAGLWSVA- 
Cyp2d34    ---------- ---------- ---------- ------MELL TGTGLWSVA- 
Cyp2d11    ---------- ---------- ---------- ------MELL TGAGLWSVA- 
Cyp2d12    ---------- ---------- ---------- ------MELL TGTDLWSVA- 
Cyp2d13    ---------- ---------- ---------- ------MELL TGTGLWPVA- 
Cyp2d40    ---------- ---------- ---------- ------MELL TGTDLWPVA- 
Cyp2d22    ---------- ---------- ---------- ------MRLP TGAELWPIA- 
Cyp2d26    ---------- ---------- ---------- ------MGLL VGDDLWAVV- 
Cyp2e1     ---------- ---------- ---------- -----MAVLG ITVALLVWIA 
Cyp2f2     ---------- ---------- ---------- -------MDG VSTAILLLLL 
Cyp2g1     ---------- ---------- ---------- ----MMLGGA FSIFMALCLS 
Cyp2j5     ---------- ---------- ---------- ---MIMFLSS LVTTFWEALH 
Cyp2j6     ---------- ---------- ---------- ---MLAATGS LLATIWAALH 
Cyp2j7     ---------- ---------- ---------- ---MLSTVGS LVARIWSAIH 
Cyp2j8     ---------- ---------- ---------- ---MFATIGC LVSNICSEIH 
Cyp2j9     ---------- ---------- ---------- ---MLAAAGS LVAAIWAALH 
Cyp2j13    ---------- ---------- ---------- ---MLEAADS LAAAFWAALH 
Cyp2j12    ---------- ---------- ---------- ---MLATEDT FETAIWALLH 
cyp2j11    ---------- ---------- ---------- ---MLAIATC LVANICSATH 
Cyp2r1     ---------- ---------- ---------- -------MLE LPGARACAGA 
Cyp2s1     ---------- ---------- ---------- ------MEAA STWALLLALL 
Cyp2t4     ---------- ---------- ---------- --------MV TCLALLLLLL 
Cyp2U1     ---------- ---------- ---------- ---MSSLGDQ RPAAGEQPG- 
Cyp2w1     ---------- ---------- ---------- --MALLLLGV WGILLLLGLW 
CYP2W1h    ---------- ---------- ---------- --MALLLL-- -LFLGLLGLW 
Cyp3a11    ---------- ---------- --------MD LVSALSLETW VLLAISLVLL 
Cyp3a13    ---------- ---------- --------MD LIPNFSMETW MLLATSLVLL 
Cyp3a16    ---------- ---------- --------MN LFSALSLDTL VLLAIILVLL 
Cyp3a25    ---------- ---------- --------ME LIPNLSIETW VLLVTSLVLF 
Cyp3a59    ---------- ---------- ---------- ---------- -------LLL 
Cyp3a57    ---------- ---------- --------ME LIPNLSIQTW VLLVTSLVFF 
Cyp3a41    ---------- ---------- --------MN LFSALSLDTW VLLAIILVLL 
Cyp3a44    ---------- ---------- --------MN LFSALSLDTL VLLAIILVLL 
Cyp4a10    ---------- --------MS VSALSPTRFA DSLSGFLQVA SVLGLLLLLV 
Cyp4a31    ---------- --------MS VSALSLTRFA GSLSGFLQVA SVFCLLLLLV 
Cyp4a32    ---------- --------MS VSALSPTRFA DSLSGFLQVA SVLGLLLLLV 
Cyp4a12a   ---------- --------MS ASALSSIRFP GSISEYLQVA SVLSLLLLLF 
Cyp4a12b   ---------- --------MS ASALSSIRFP GSISEYLQVA SVLSLLLLLF 
Cyp4a14    ---------- --------MG FFLFSPTRYL DGISGFFQWA FLLSLFLVLF 
Cyp4a30b   ---------- --------MS IFELSHITNV FGIFGLLQVV SLLGLLLLLL 
Cyp4a29    ---------- --------MS ISALSPIRFL ECVSGFLQVI FLIGLLLLLF 
Cyp4b1     ---------- --------MA LSFLSP---- -SLSRLGLWA SVVILMVTVL 
Cyp4f13    ---------- --------ML QLCLSWLGMG SLTASPWHLL LLGGASWILA 
Cyp4f14    ---------- --------MS QLSLSWLGLG PEVAFPWKTL LLLGASWILA 
Cyp4f15    ---------- ---MGFFRMP QLDLSWLGLR LEASSPWLLL LLIGASWLLA 
Cyp4f16    ---------- --------ML RLSVSGLDLG SVVTSSWHLL LLGVASWILA 
Cyp4f17    ---------- --------ML QLGLSWLGLG PGAAFPWQLL QLVGASLFLA 
Cyp4f18    ---------- --------MS QLSLSWMGLG HTAASPWLLL LLAGASCLLA 
Cyp4f37    ---------- --------ML RLSVSGLDLG SVVTLSWHLL LLGAASWILA 
Cyp4f39    ---------- MLPLTDYLLQ LLGLEKTAFR VYVVSALLLL VLFFFFRLLV 
Cyp4f40    ---------- --------MR YLDLSWLGLG PMSASPWLLF FLVGISWFLA 
Cyp4v3     ---------- --------ML WLWLGLSGQK LLLWGAASAV SLAGATILIS 
Cyp4x1     ---------- ---------- ---MEASWLE TRWARPLHLA LVFCLALVLM 
Cyp5a1     ---------- ---------- --MEVLGLLK FEVSGTIVTV TLLVALLALL 
Cyp7a1     ---------- ---------- ---------- ---MMSISLI WGIAVVVSCC 
Cyp7b1     ---------- ---------- ---MQGATTL DAASPGPLAL LGLLFAATLL 
Cyp8a1     ---------- ---------- ---------- ----MSWAAL LGLLAVLLL- 
Cyp8b1     ---------- ---------- ---------- ---MTLWCTV LGALLTVVG- 
Cyp11a1    ---------- ---------- -----MLAKG LSLRSVLVKG CQPFLSPTWQ 
Cyp11b1    ---------- ---------- ---------- ----MALRVT TDVWLARPWQ 
Cyp11b2    ---------- ---------- ---------- ----MALRVT ADVWLARPWQ 
Cyp17      ---------- ---------- ---------- ---MWELVGL LLLILAYFFW 
Cyp19      ---------- ---------- ---------- --MFLEMLNP MQYNVTIMVP 
Cyp20      ---------- ---------- -------MLD FAIFAVTFLL ALVGAVLYLY 
Cyp21      ---------- ---------- ---------- -------MLL PGLLLLLLLL 
Cyp24      ---------- ---------- ---------- ----MSCPID KRRPLIAFLR 
Cyp26a1    ---------- ---------- ---MGLPALL ASALCTFVLP LLLFLAALKL 
Cyp26b1    ---------- --------ML FEGLELVSAL ATLAACLVSV TLLLAVSQQL 
Cyp26c1    ---------- --------MI SWGLSCLSVL GAAGTTLLCA GLLLGLAQQL 
Cyp27a1    ---------- ---------- ---------- ------MAAW SRTRLRWTLL 
Cyp27b1    ---------- ---------- --------LE ADSPNTDMTQ AVKLASRVFH 
Cyp39      ---------- ---------- ---------- ----MGIMEL FSPIAIAVLG 
Cyp46      ---------- ---------- ------MSPG LLLLGSAVLL AFGLCCTFVH 
Cyp51      ---------- ---------- ---MEQVTGG NLLSTLLIAC AFTLSLVYLF 
CYP1A1h    ---------- ---------- ---------- ---MLFPISM SATEFLLASV 
CYP1A2h    ---------- ---------- ---------- -MALSQSVPF SATELLLASA 
CYP1B1h    ---------- ---------- --MGTSLSPN DPWPLNPLSI QQTTLLLLLS 
CYP2A6     ---------- ---------- ---------- ----MLASGM LLVALLVCLT 
CYP2A7     ---------- ---------- ---------- ----MLASGL LLVALLACLT 
CYP2A13    ---------- ---------- ---------- ----MLASGL LLVTLLACLT 
CYP2B6     ---------- ---------- ---------- ------MELS VLLFLALLTG 
CYP2C8     ---------- ---------- ---------- --------ME PFVVLVLCLS 
CYP2C9     ---------- ---------- ---------- --------MD SLVVLVLCLS 
CYP2C18    ---------- ---------- ---------- --------MD PAVALVLCLS 
CYP2C19    ---------- ---------- ---------- --------MD PFVVLVLCLS 
CYP2D6     ---------- ---------- ---------- ---------M GLEALVPLA- 
CYP2E1h    ---------- ---------- ---------- -----MSALG VTVALLVWAA 
CYP2F1     ---------- ---------- ---------- -------MDS ISTAILLLLL 
CYP2G2P    ---------- ---------- ---------- ----MEMGGA VTIFLALCLS 
CYP2J2     ---------- ---------- ---------- ---MLAAMGS LAAALWAVVH 
CYP2R1h    ---------- ---------- ---------- -------MWK LWRAEEGAAA 
CYP2S1h    ---------- ---------- ---------- ------MEAT GTWALLLALA 
CYP2T2P    ---------- ---------- ---------- ---------- ---------- 
CYP2U1h    ---------- ---------- ---------- ---MSSPGPS QPPAEDPPWP 
CYP3A4     ---------- ---------- --------MA VIPDLAMETW LLLAVSLVLL 
CYP3A5     ---------- ---------- --------MD LIPNLAVETW LLLAVSLVLL 
CYP3A7     ---------- ---------- --------MD LIPNLAVETW LLLAVSLILL 
CYP3A43    ---------- ---------- --------MD LIPNFAMETW VLVATSLVLL 
CYP4A11    ---------- --------MS VSVLSPSRLL GDVSGILQAA SLLILLLLLI 
CYP4A22    ---------- --------MS VSVLSPSRRL GGVSGILQVT SLLILLLLLI 
CYP4B1h    ---------- ---------- ---MVPSFLS LSFSSLGLWA SGLILVLGFL 
CYP4F2     ---------- --------MS QLSLSWLGLW PVAASPWLLL LLVGASWLLA 
CYP4F3     ---------- --------MP QLSLSSLGLW PMAASPWLLL LLVGASWLLA 
CYP4F8     ---------- --------MS LLSLSWLGLR PVAASPWLLL LVVGASWLLA 
CYP4F11    ---------- --------MP QLSLSWLGLG PVAASPWLLL LLVGGSWLLA 
CYP4F12    ---------- --------MS LLSLPWLGLR PVAMSPWLLL LLVVGSWLLA 
CYP4F22    ---------- MLPITDRLLH LLGLEKTAFR IYAVSTLLLF LLFFLFRLLL 
CYP4F23P   ---------- --------MS LLSLSWLGLG PVAASPWLLL LLVGASWLLA 
CYP4V2     ---------- --------MA GLWLGLVWQK LLLWGAASAV SLAGASLVLS 
CYP4X1h    ---------- ---------- ---MEFSWLE TRWARPFYLA FVFCLALGLL 
CYP4Z1     ---------- ---------- ---MEPSWLQ ELMAHPFLLL ILLCMSLLLF 
CYP5A1h    ---------- ---------- -MMEALGFLK LEVNGPMVTV ALSVALLALL 
CYP7A1h    ---------- ---------- ---------- ---MMTTSLI WGIAIAACCC 
CYP7B1h    ---------- ---------- -MAGEVSAAT GRFSLERLGL PGLALAAALL 
CYP8A1h    ---------- ---------- ---------- ----MAWAAL LGLLVALLL- 
CYP8B1h    ---------- ---------- ---------- ---MVLWGPV LGALLVVIAG 
CYP11A1h   ---------- ---------- -----MLAKG LPPRSVLVKG YQTFLSAPRE 
CYP11B1h   ---------- ---------- ---------- ----MALRAK AEVCMAVPWL 
CYP11B2h   ---------- ---------- ---------- ----MALRAK AEVCVAAPWL 
CYP17h     ---------- ---------- ---------- ---MWELVAL LLLTLAYLFW 
CYP19h     ---------- ---------- ---------- --MVLEMLNP IHYNITSIVP 
CYP20h     ---------- ---------- -------MLD FAIFAVTFLL ALVGAVLYLY 
CYP21A2h   ---------- ---------- ---------- -------MLL LGLLLLLPLL 
CYP24h     ---------- ---------- ---------- ----MSSPIS KSRSLAAFLQ 
CYP26A1h   ---------- ---------- ---MGLPALL ASALCTFVLP LLLFLAAIKL 
CYP26B1h   ---------- --------ML FEGLDLVSAL ATLAACLVSV TLLLAVSQQL 
CYP26C1h   ---------- --------MF PWGLSCLSVL GAAGTALLCA GLLLSLAQHL 
CYP27A1h   ---------- ---------- ---------- ------MAAL GCARLRWALR 
CYP27B1h   ---------- ---------- ---------- -------MTQ TLKYASRVFH 
CYP27C1h   ---------- ---------- ---------- ------MQTS AMALLARILR 
CYP39A1h   ---------- ---------- ---------- -------MEL ISPTVIIILG 
CYP46h     ---------- ---------- ------MSPG LLLLGSAVLL AFGLCCTFVH 
CYP51h     MAAAAGMLLL GLLQAGGSVL GQAMEKVTGG NLLSMLLIAC AFTLSLVYLI 

Cyp1a1     ---------- ---------- VFCLGFWVVR A--------- ---------- 
Cyp1a2     ---------- ---------- IFCLVFWMVR A--------- ---------- 
Cyp1b1     ---------- ---------- VLAAVHLGQW L--------- ---------- 
Cyp2a4     ---------- ---------- VLVLMSVW-- ---------- ---------- 
Cyp2a5     ---------- ---------- VLVLMSVW-- ---------- ---------- 
Cyp2a12    ---------- ---------- VMVLVSVW-- ---------- ---------- 
Cyp2a22    ---------- ---------- VMVLVSVW-- ---------- ---------- 
Cyp2b9     ---------- ---------- LFLLLVR--- ---------- ---------- 
Cyp2b10    ---------- ---------- FLLLLAR--- ---------- ---------- 
Cyp2b13    ---------- ---------- LFLLLVR--- ---------- ---------- 
Cyp2b19    ---------- ---------- FLIFLVSQ-- ---------- ---------- 
Cyp2b23    ---------- ---------- FLLLLIR--- ---------- ---------- 
Cyp2c29    ---------- ---------- CLILLSLW-- ---------- ---------- 
Cyp2c37    ---------- ---------- CLFLLSLW-- ---------- ---------- 
Cyp2c38    ---------- ---------- SLILLSLW-- ---------- ---------- 
Cyp2c39    ---------- ---------- SLILLSLW-- ---------- ---------- 
Cyp2c40    ---------- ---------- FLLVLSLW-- ---------- ---------- 
Cyp2c44    ---------- ---------- SLSLLSVW-- ---------- ---------- 
Cyp2c50    ---------- ---------- CLFLLSLW-- ---------- ---------- 
Cyp2c54    ---------- ---------- CLFLLSLW-- ---------- ---------- 
Cyp2c55    ---------- ---------- CLLLLSLW-- ---------- ---------- 
Cyp2c65    ---------- ---------- CLLLLSLW-- ---------- ---------- 
Cyp2c66    ---------- ---------- CLLLLSLW-- ---------- ---------- 
Cyp2c67    ---------- ---------- FLLVLSLW-- ---------- ---------- 
Cyp2c68    ---------- ---------- FLLLLSLW-- ---------- ---------- 
Cyp2c69    ---------- ---------- FMLLLSLW-- ---------- ---------- 
Cyp2c70    ---------- ---------- CFLFLFLW-- ---------- ---------- 
Cyp2ac1    ---------- --------LI LILHINVF-- ---------- ---------- 
Cyp2ab1    ---------- ---------- CLLLKLA--- ---------- ---------- 
Cyp2d9     ---------- --------IF TVIFILLVDL T--------- ---------- 
Cyp2d10    ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d34    ---------- --------IF TVIFLILVDL M--------- ---------- 
Cyp2d11    ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d12    ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d13    ---------- --------IF TVIFILLVDL M--------- ---------- 
Cyp2d40    ---------- --------IF TVIFILLVDL L--------- ---------- 
Cyp2d22    ---------- --------IF TVIFLILVNL M--------- ---------- 
Cyp2d26    ---------- --------IF TAIFLLLVDL V--------- ---------- 
Cyp2e1     ---------- ---------- TLLLVSIW-- ---------- ---------- 
Cyp2f2     ---------- ---------- AVISLSLT-- ---------- ---------- 
Cyp2g1     ---------- ---------- CLLILIAW-- ---------- ---------- 
Cyp2j5     LK-------- --------TL VLAVVTFLFL I--------- ---------- 
Cyp2j6     PR-------- --------TL LVAAVTFLLL A--------- ---------- 
Cyp2j7     LW-------- --------TL LLTLLVFRLL A--------- ---------- 
Cyp2j8     LW-------- --------TL LLAALTLLLL V--------- ---------- 
Cyp2j9     LR-------- --------IL LLSAVTFLFL A--------- ---------- 
Cyp2j13    LR-------- --------TL LLAAVTFLFL A--------- ---------- 
Cyp2j12    FK-------- --------TL VLAAVTFMLL A--------- ---------- 
cyp2j11    LW-------- --------TL LLTLLTLLLL A--------- ---------- 
Cyp2r1     LA-------- --------GA LLLLLFVLVV R--------- ---------- 
Cyp2s1     ---------- ---------- LLLLLLS--- L--------- ---------- 
Cyp2t4     ---------- ---------- ILMLLLWWGG V--------- ---------- 
Cyp2U1     --------AR LHVRATGGAL LLCLLAVLLG W--------- ---------- 
Cyp2w1     ---------- ---------- GLLQGCTR-- ---------- ---------- 
CYP2W1h    ---------- ---------- GLLCACAQ-- ---------- ---------- 
Cyp3a11    Y--------- ---------- RYGTRKHEL- ---------- ---------- 
Cyp3a13    Y--------- ---------- LYGTHSHGI- ---------- ---------- 
Cyp3a16    Y--------- ---------- RYGTYTHGL- ---------- ---------- 
Cyp3a25    Y--------- ---------- IYGTYSHGL- ---------- ---------- 
Cyp3a59    Y--------- ---------- RYGTYSHGL- ---------- ---------- 
Cyp3a57    Y--------- ---------- IYGTYSHGL- ---------- ---------- 
Cyp3a41    Y--------- ---------- RYGTRTHGL- ---------- ---------- 
Cyp3a44    Y--------- ---------- RYGTRTHGL- ---------- ---------- 
Cyp4a10    K--------- ---------- AVQFYLHRQ- ---------- ---------- 
Cyp4a31    K--------- ---------- AVQVYLHRK- ---------- ---------- 
Cyp4a32    K--------- ---------- AVQFYLHRK- ---------- ---------- 
Cyp4a12a   K--------- ---------- TAQLYLHRQ- ---------- ---------- 
Cyp4a12b   K--------- ---------- TAQLYLHRQ- ---------- ---------- 
Cyp4a14    K--------- ---------- AVQFYLRRQ- ---------- ---------- 
Cyp4a30b   K--------- ---------- SAQYYLHRQ- ---------- ---------- 
Cyp4a29    K--------- ---------- AAQHYLRRQ- ---------- ---------- 
Cyp4b1     K--------- ---------- LLSLLFRRQ- ---------- ---------- 
Cyp4f13    R--------- ---------- ILAWIYAFY- ---------- ---------- 
Cyp4f14    R--------- ---------- ILIQIYAAY- ---------- ---------- 
Cyp4f15    R--------- ---------- VLTQTYIFY- ---------- ---------- 
Cyp4f16    R--------- ---------- ILAWTYSFY- ---------- ---------- 
Cyp4f17    R--------- ---------- ILTWICAFY- ---------- ---------- 
Cyp4f18    Y--------- ---------- ILTQIYGVF- ---------- ---------- 
Cyp4f37    R--------- ---------- ILAWTYSFC- ---------- ---------- 
Cyp4f39    R--------- ---------- AFKLFSDFR- ---------- ---------- 
Cyp4f40    R--------- ---------- FLTQLYTLY- ---------- ---------- 
Cyp4v3     ---------- ---------- IFPMLVSYA- ---------- ---------- 
Cyp4x1     Q--------- ---------- AMKLYLRRQ- ---------- ---------- 
Cyp5a1     K--------- ---------- WYSMSAFSR- ---------- ---------- 
Cyp7a1     ---------- ---------- IWFIIGIRR- ---------- ---------- 
Cyp7b1     ---------- ---------- LSALFLLTRR ---------- ---------- 
Cyp8a1     ---------- ---------- LLLLLSRRR- ---------- ---------- 
Cyp8b1     ---------- ---------- CLCLSLLLR- ---------- ---------- 
Cyp11a1    GP-------- --------VL STGKGAGTST S--------- ---------- 
Cyp11b1    CLHR------ --------TR ALGTTATLAP K--------- ---------- 
Cyp11b2    CLHR------ --------TR ALGTTATLAP K--------- ---------- 
Cyp17      P--------- ---------- ---------- ---------- ---------- 
Cyp19      ---------- -------ETV TVSAMPLLLI MG-------- ---------- 
Cyp20      P--------- ---------- ASRQASGIP- ---------- ---------- 
Cyp21      A--------- ---------- ---------- ---------- ---------- 
Cyp24      R--------- --------LR DLGQPPRSVT SKAHVKRAPK E--------- 
Cyp26a1    ---------- ---------- WDLYCVSSRD ---------- ---------- 
Cyp26b1    ---------- ---------- WQLRWAATRD ---------- ---------- 
Cyp26c1    ---------- ---------- WTLRWTLSRD ---------- ---------- 
Cyp27a1    DPRVVG---- -RGLCPQGAR AKATIPAALQ AQESTEGPGT G--------- 
Cyp27b1    R--------- --------IH LPLQLDASLG S--------- ---------- 
Cyp39      ---------- ---------- SCVLFLFSR- ---------- ---------- 
Cyp46      R--------- ---------- ARSRYEHIP- ---------- ---------- 
Cyp51      ---------- ---------- RLAVGHMVQL ---------- ---------- 
CYP1A1h    ---------- ---------- IFCLVFWVIR A--------- ---------- 
CYP1A2h    ---------- ---------- IFCLVFWVLK G--------- ---------- 
CYP1B1h    ---------- ---------- VLATVHVGQR L--------- ---------- 
CYP2A6     ---------- ---------- VMVLMSVW-- ---------- ---------- 
CYP2A7     ---------- ---------- VMVLMSVW-- ---------- ---------- 
CYP2A13    ---------- ---------- VMVLMSVW-- ---------- ---------- 
CYP2B6     ---------- ---------- LLLLLVQ--- ---------- ---------- 
CYP2C8     ---------- ---------- FMLLFSLW-- ---------- ---------- 
CYP2C9     ---------- ---------- CLLLLSLW-- ---------- ---------- 
CYP2C18    ---------- ---------- CLFLLSLW-- ---------- ---------- 
CYP2C19    ---------- ---------- CLLLLSIW-- ---------- ---------- 
CYP2D6     ---------- --------VI VAIFLLLVDL M--------- ---------- 
CYP2E1h    ---------- ---------- FLLLVSMW-- ---------- ---------- 
CYP2F1     ---------- ---------- ALVCLLLT-- ---------- ---------- 
CYP2G2P    ---------- ---------- CLLILIAW-- ---------- ---------- 
CYP2J2     PR-------- --------TL LLGTVAFLLA A--------- ---------- 
CYP2R1h    LG-------- --------GA LFLLLFALGV R--------- ---------- 
CYP2S1h    ---------- ---------- LLLLLT---- L--------- ---------- 
CYP2T2P    ---------- ---------- ---------- ---------- ---------- 
CYP2U1h    ARLLRAPLGL LRLDPSGGAL LLCGLVALLG W--------- ---------- 
CYP3A4     Y--------- ---------- LYGTHSHGL- ---------- ---------- 
CYP3A5     Y--------- ---------- LYGTRTHGL- ---------- ---------- 
CYP3A7     Y--------- ---------- LYGTRTHGL- ---------- ---------- 
CYP3A43    Y--------- ---------- IYGTHSHKL- ---------- ---------- 
CYP4A11    K--------- ---------- AVQLYLHRQ- ---------- ---------- 
CYP4A22    K--------- ---------- AAQLYLHRQ- ---------- ---------- 
CYP4B1h    K--------- ---------- LIHLLLRRR- ---------- ---------- 
CYP4F2     H--------- ---------- VLAWTYAFY- ---------- ---------- 
CYP4F3     R--------- ---------- ILAWTYTFY- ---------- ---------- 
CYP4F8     R--------- ---------- ILAWTYAFY- ---------- ---------- 
CYP4F11    R--------- ---------- VLAWTYTFY- ---------- ---------- 
CYP4F12    R--------- ---------- ILAWTYAFY- ---------- ---------- 
CYP4F22    R--------- ---------- FLRLCRSFY- ---------- ---------- 
CYP4F23P   R--------- ---------- VLAWTYAFY- ---------- ---------- 
CYP4V2     ---------- ---------- LLQRVASYA- ---------- ---------- 
CYP4X1h    Q--------- ---------- AIKLYLRRQ- ---------- ---------- 
CYP4Z1     Q--------- ---------- VIRLYQRRR- ---------- ---------- 
CYP5A1h    K--------- ---------- WYSTSAFSR- ---------- ---------- 
CYP7A1h    ---------- ---------- LWLILGIRR- ---------- ---------- 
CYP7B1h    ---------- ---------- LLALCLLVRR ---------- ---------- 
CYP8A1h    ---------- ---------- LLLLS-RRR- ---------- ---------- 
CYP8B1h    ---------- ---------- YLCLPGMLR- ---------- ---------- 
CYP11A1h   GLGRL----- --------RV PTGEGAGIST R--------- ---------- 
CYP11B1h   SLQR------ --------AQ ALGTRAARVP R--------- ---------- 
CYP11B2h   SLQR------ --------AR ALGTRAARAP R--------- ---------- 
CYP17h     P--------- ---------- ---------- ---------- ---------- 
CYP19h     ---------- -------EAM PAATMPVLLL TG-------- ---------- 
CYP20h     P--------- ---------- ASRQAAGIP- ---------- ---------- 
CYP21A2h   A--------- ---------- ---------- ---------- ---------- 
CYP24h     Q--------- --------LR SPRQPPRLVT STAYTSPQPR E--------- 
CYP26A1h   ---------- ---------- WDLYCVSGRD ---------- ---------- 
CYP26B1h   ---------- ---------- WQLRWAATRD ---------- ---------- 
CYP26C1h   ---------- ---------- WTLRWMLSRD ---------- ---------- 
CYP27A1h   G--AG----- -RGLCPHGAR AKAAIPAALP SDKATGAPGA G--------- 
CYP27B1h   R--------- --------VR WAPELGASLG Y--------- ---------- 
CYP27C1h   AG-------- --------LR PAPERGGLLG GGAPRRPQPA GARLPAGARA 
CYP39A1h   ---------- ---------- CLALFLLLQ- ---------- ---------- 
CYP46h     R--------- ---------- ARSRYEHIP- ---------- ---------- 
CYP51h     ---------- ---------- RLAAGHLVQL ---------- ---------- 

Cyp1a1     ---------- ----TRTWVP KGLKTPPGPW GLPFIGHMLT VGKNPH---- 
Cyp1a2     ---------- ----SRTQVP KGLKNPPGPW GLPFIGHMLT VGKNPH---- 
Cyp1b1     ---------- ----LRQWQR KPWSSPPGPF PWPLIGNAAA VGQASH---- 
Cyp2a4     ---------- ------KQRK LSGKLPPGPT PLPFVGNFLQ LNTEQMY--- 
Cyp2a5     ---------- ------KQRK LSGKLPPGPT PLPFIGNFLQ LNTEQMY--- 
Cyp2a12    ---------- ------QQKI R-GKLPPGPI PLPFIGNYLQ LNRKDVY--- 
Cyp2a22    ---------- ------QQKI R-GKLPPGPI PLPFIGNYLQ LNRKDVY--- 
Cyp2b9     ---------- ------GHAK IHGHLPPGPH PLPLLGNLLQ MDRGGLL--- 
Cyp2b10    ---------- ------GHPK SRGNFPPGPR PLPLLGNLLQ MDRGGLL--- 
Cyp2b13    ---------- ------GHAK IHGHLPPGPR PLPLLGNLLQ MDRGGLL--- 
Cyp2b19    ---------- ------SQPK THGHFPPGPR PLPFLGNLLQ MDRRGLL--- 
Cyp2b23    ---------- ------GQPK AYSRLPPGPR PLPFLGNLLQ MDRGGLL--- 
Cyp2c29    ---------- ------RQSS GRGKLPPGPT PLPIIGNFLQ IDVKNIS--- 
Cyp2c37    ---------- ------RQSS ERGKLPPGPT PLPIIGNILQ IDVKDIC--- 
Cyp2c38    ---------- ------RQRS RRGRLPPGPT PFPIIGNFLQ IDVKNFN--- 
Cyp2c39    ---------- ------RQSC GRGSLPPGPT PFPIIGNFLQ IDMKNFS--- 
Cyp2c40    ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c44    ---------- ------TKMR TGGRLPPGPT PLPIIGNILQ LDLKDIP--- 
Cyp2c50    ---------- ------RQSS ERGKLPPGPT PLPIIGNILQ INVKDIC--- 
Cyp2c54    ---------- ------RQSY ERGKLPPGPT PLPIIGNILQ IDVKDIC--- 
Cyp2c55    ---------- ------RQNS GRGKLPPGPT PFPIIGNILQ IDIKNIS--- 
Cyp2c65    ---------- ------RQNS QRRNLPPGPT PLPIIGNILQ LDLKDIS--- 
Cyp2c66    ---------- ------KQNS QRRNLPPGPT PLPIIGNILQ LDLKDIS--- 
Cyp2c67    ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c68    ---------- ------RQRS ARGNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c69    ---------- ------RQRS ARRNLPPGPT PLPIIGNYHL IDMKDIG--- 
Cyp2c70    ---------- ------NQHR GRGKLPPGPT PLPIVGNILQ VYVKNIS--- 
Cyp2ac1    ---------- ------MAKA SKHQSPPGRK SWPVIGNLHI ---------- 
Cyp2ab1    ---------- ------TLCW RRSHLPPGPF PFPLLGNLWQ LNFQLHP--- 
Cyp2d9     ---------- ----HQR-QR WTSRYPPGPV PWPVLGNLLQ VDLGNMP--- 
Cyp2d10    ---------- ----HRH-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d34    ---------- ----HRR-QH WTSRYPPGPV PWPVLGNLLQ VDLDNIP--- 
Cyp2d11    ---------- ----HRH-QH WTSRCPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d12    ---------- ----YRR-QS WTSCYPPGPV PWPVLGNLLQ VDLNNMP--- 
Cyp2d13    ---------- ----HRR-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d40    ---------- ----HRR-QR WTSRYPPGPV PWPVLGNLLQ VDLDNMP--- 
Cyp2d22    ---------- ----HWR-QR WTAHYPPGPM PWPVLGNLLH MDFQNMP--- 
Cyp2d26    ---------- ----HRR-QR WTACYPPGPV PFPGLGNLLQ VDFENIP--- 
Cyp2e1     ---------- ------KQIY RSWNLPPGPF PIPFFGNIFQ LDLKDIP--- 
Cyp2f2     ---------- ------FSSR GKGQLPPGPK PLPILGNLLQ LRSQDLL--- 
Cyp2g1     ---------- ------KRTS KGGKLPPGPT PIPFLGNFLQ VRTDATF--- 
Cyp2j5     ---------- ----NILRSR HPKNYPPGPW RLPFVGNFFQ IDTKQT---- 
Cyp2j6     ---------- ----DYFKNR RPKNYPPGPW GLPFVGNIFQ LDFGQP---- 
Cyp2j7     ---------- ----DYLKNR RPKNYPPGPW RLPFVGNLFQ FDLDVSQ--- 
Cyp2j8     ---------- ----DYIKNR HPKNYPPGPW RLPFVGNLFQ FDLDVSH--- 
Cyp2j9     ---------- ----DFLKNR RPKNYPPWPM RLPFVGCLFH LDPKQP---- 
Cyp2j13    ---------- ----DYLKSR RPKNYPPRPP RLPFVGNSFQ MDLTQS---- 
Cyp2j12    ---------- ----HYLKTQ RPKNYPPGPW RLPFVGNLFQ LDLEQP---- 
cyp2j11    ---------- ----DYLKNR RPKNYPPGPR RLPFVGNLFQ FDLDVSR--- 
Cyp2r1     ---------- ----QLLRQR RPAGFPPGPP RLPFVGNICS LALSADL--- 
Cyp2s1     ---------- ----TLFRTP ARGYLPPGPT PLPLLGNLLQ LRPGALY--- 
Cyp2t4     ---------- ----VRRQAQ MQKDLPPGPA PLPLLGNLLQ LQSGDLD--- 
Cyp2U1     ---------- ----VWLRRQ RACGIPPGPK PRPLVGNFGH LLVPRFLRPQ 
Cyp2w1     ---------- -------SPS LAPRWPPGPR PLPFLGNLHL LGVTQQD--- 
CYP2W1h    ---------- -------DPS PAARWPPGPR PLPLVGNLHL LRLSQQD--- 
Cyp3a11    ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYKG------ 
Cyp3a13    ---------- ---------- FKKLGIPGPK PLPFLGTILA YQKG------ 
Cyp3a16    ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYKG------ 
Cyp3a25    ---------- ---------- FKKLGIPGPK PLPLLGTIFN YYDG------ 
Cyp3a59    ---------- ---------- FKKLGIPGPK PLPLFGTIFN YFDG------ 
Cyp3a57    ---------- ---------- FKKLGIPGPK PLPLFGNIIN YLDG------ 
Cyp3a41    ---------- ---------- FKKQGIPGPT PLPFLGTVLN YYKG------ 
Cyp3a44    ---------- ---------- FKKQGIPGPK PLPFLGTVLN YYTG------ 
Cyp4a10    ---------- ------WLLK AFQQFPSPPF -HWFFGHEQF KG---DH--- 
Cyp4a31    ---------- ------WLLK ALQQFPSPPF -HWFFGHEQF KG---DQ--- 
Cyp4a32    ---------- ------WLLK ALQQFPSPPF -HWFFGHEQF KG---EQ--- 
Cyp4a12a   ---------- ------WLLS STQQFPSPPS -HWLFGHKIL KD----Q--- 
Cyp4a12b   ---------- ------WLLS STQQFPSPPS -HWLFGHKIL KD----Q--- 
Cyp4a14    ---------- ------WLLK TLQHFPCMPS -HWLWGHH-L KD----K--- 
Cyp4a30b   ---------- ------WLIK SLQQFPPAPP PQWLFGNIFP KD----Q--- 
Cyp4a29    ---------- ------WLLR ALYQFPSPPS -HWLFGHQFK VD----E--- 
Cyp4b1     ---------- ------KLAR ALDSFPGPPK -HWLFGHALE IQK--TG--- 
Cyp4f13    ---------- ------DNCS RLRCFPQPPK PSWFWGHLAL MKNN-EE--- 
Cyp4f14    ---------- ------RNYR HLHGFPQPPK RNWLMGHVGM VTPT-EQ--- 
Cyp4f15    ---------- ------RTYH HLCDFPQPPK WNWFLGHLGM ITPT-EH--- 
Cyp4f16    ---------- ------ENCS RLSCFPQPPK KNWFSGHLGM IQSN-EE--- 
Cyp4f17    ---------- ------DNYC RLRCFPEPPS RHWFWGHMSM VKNN-EE--- 
Cyp4f18    ---------- ------ENSL RLRCFPQPPK RNWILGHLGL IQSS-EE--- 
Cyp4f37    ---------- ------ENCS RLRCFPQPPK RNWFLGHLGM IEHN-EE--- 
Cyp4f39    ---------- ------ITCR KLSCFPEPPG RHWLLGHMSM VSPN-EK--- 
Cyp4f40    ---------- ------AKCQ RLCGFPQPPK KNWFWGHLGM VSPT-EE--- 
Cyp4v3     ---------- ------RKWQ QMRSIPSVAR AYPLVGHALY MKPNNAE--- 
Cyp4x1     ---------- ------RLLR DLSPFPGPPA -HWLLGHQKF LQ---ED--- 
Cyp5a1     ---------- ------LEKL GIRHPKPSP- ---FVGNLMF FRQG------ 
Cyp7a1     ---------- ---------R KVGEPPLDNG LIPYLGCALK FGSNPLE--- 
Cyp7b1     ---------- --------TR RPREPPLIKG WLPYLGMALK FFKDPLT--- 
Cyp8a1     ---------- --------AR RPGEPPLDLG SIPWLGHALE FGRDAAS--- 
Cyp8b1     ---------- --------HR RPWEPPLDKG FVPWLGHSMA FRKNMFE--- 
Cyp11a1    ---------- ------SPRS FNEIPSPGDN GWLNLYHFWR ESGTQKIH-- 
Cyp11b1    ---------- ------TLQP FEAIPQYSRN KWLKMIQILR EQGQENLH-- 
Cyp11b2    ---------- ------TLQP FEAIPQYSRN KWLKMIQILR EQGQENLH-- 
Cyp17      ---------- ------KSKT PNAKFPRSLP FLPLVGSLPF LPRRGHMH-- 
Cyp19      ---------- --LLLLIWNC ESSSSIPGPG YCLGIGPLIS HGRFLWMG-- 
Cyp20      ---------- ------GLTP TEEKDGNLP- -------DIV NSGSLHE--- 
Cyp21      ---------- ------GTRW LWGQWKLRKL HLPPLAPGFL HFLQPNLP-- 
Cyp24      -----VPLCP LMTDGETRNV TSLPGPTNWP LLGSLLEIFW KGGLKKQH-- 
Cyp26a1    ---------- --------RS CALPLPPGTM GFPFFGETLQ MVLQRRK--- 
Cyp26b1    ---------- --------KS CKLPIPKGSM GFPLIGETGH WLLQGSG--- 
Cyp26c1    ---------- --------WA STLPLPKGSM GWPFFGETLH WLVQGSR--- 
Cyp27a1    ---------- ---Q-DRPRL RSPAELPGTG TLQFLFQLFL QGYVLHLP-- 
Cyp27b1    ---------- ---RGSESVL RSLSDIPGPS TLSFLAELFC KGGLSRLH-- 
Cyp39      ---------- --------LK NLLGPPCIQG WIPWIGAGLE FGKAPLE--- 
Cyp46      ---------- ------GPPR PSFLLGHLPY ---FWKKDED CGRVLQD--- 
Cyp51      ---------- --------PA GAKSPPHIYS PIPFLGHAIA FGKSPIE--- 
CYP1A1h    ---------- ----SRPQVP KGLKNPPGPW GWPLIGHMLT LGKNPH---- 
CYP1A2h    ---------- ----LRPRVP KGLKSPPEPW GWPLLGHVLT LGKNPH---- 
CYP1B1h    ---------- ----LRQRRR QLRSAPPGPF AWPLIGNAAA VGQAAH---- 
CYP2A6     ---------- ------QQRK SKGKLPPGPT PLPFIGNYLQ LNTEQMY--- 
CYP2A7     ---------- ------QQRK SRGKLPPGPT PLPFIGNYLQ LNTEHIC--- 
CYP2A13    ---------- ------RQRK SRGKLPPGPT PLPFIGNYLQ LNTEQMY--- 
CYP2B6     ---------- ------RHPN THDRLPPGPR PLPLLGNLLQ MDRRGLL--- 
CYP2C8     ---------- ------RQSC RRRKLPPGPT PLPIIGNMLQ IDVKDIC--- 
CYP2C9     ---------- ------RQSS GRGKLPPGPT PLPVIGNILQ IGIKDIS--- 
CYP2C18    ---------- ------RQSS GRGRLPSGPT PLPIIGNILQ LDVKDMS--- 
CYP2C19    ---------- ------RQSS GRGKLPPGPT PLPVIGNILQ IDIKDVS--- 
CYP2D6     ---------- ----HRR-QR WAARYPPGPL PLPGLGNLLH VDFQNTP--- 
CYP2E1h    ---------- ------RQVH SSWNLPPGPF PLPIIGNLFQ LELKNIP--- 
CYP2F1     ---------- ------LSSR DKGKLPPGPR PLSILGNLLL LCSQDML--- 
CYP2G2P    ---------- ------KMN- KAGKLPPGPT PIPFLGNLLQ VRTDATF--- 
CYP2J2     ---------- ----DFLKRR RPKNYPPGPW RLPFLGNFFL VDFEQS---- 
CYP2R1h    ---------- ----QLLKQR RPMGFPPGPP GLPFIGNIYS LAASSEL--- 
CYP2S1h    ---------- ----ALSGTR ARGHLPPGPT PLPLLGNLLQ LRPGALY--- 
CYP2T2P    ---------- -------RAQ MRGSLPPRPR PLPLLG-NLQ LQSGGLD--- 
CYP2U1h    ---------- ----SWLRRR RARGIPPGPT PWPLVGNFGH VLLPPFLRRR 
CYP3A4     ---------- ------FKKL GIPGPTPLP- ---FLGNILS YHKG------ 
CYP3A5     ---------- ------FKRL GIPGPTPLP- ---LLGNVLS YRQG------ 
CYP3A7     ---------- ------FKKL GIPGPTPLP- ---FLGNALS FRKG------ 
CYP3A43    ---------- ------FKKL GIPGPTPLP- ---FLGTILF YLRG------ 
CYP4A11    ---------- ------WLLK ALQQFPCPPS -HWLFGHIQE LQQ--DQ--- 
CYP4A22    ---------- ------WLLK ALQQFPCPPS -HWLFGHIQE FQH--DQ--- 
CYP4B1h    ---------- ------TLAK AMDKFPGPPT -HWLFGHALE IQE--TG--- 
CYP4F2     ---------- ------DNCR RLRCFPQPPR RNWFWGHQGM IHSS-EE--- 
CYP4F3     ---------- ------DNCC RLRCFPQPPK RNWFLGHLGL IHSS-EE--- 
CYP4F8     ---------- ------HNGR RLRCFPQPRK QNWFLGHLGL VTPT-EE--- 
CYP4F11    ---------- ------DNCR RLQCFPQPPK QNWFWGHQGL VTPT-EE--- 
CYP4F12    ---------- ------NNCR RLQCFPQPPK RNWFWGHLGL ITPT-EE--- 
CYP4F22    ---------- ------ITCR RLRCFPQPPR RNWLLGHLGM VSPN-EA--- 
CYP4F23P   ---------- ------DNCH RLQCFQQPPK RNCFG-HLSL VSGN-EE--- 
CYP4V2     ---------- ------RKWQ QMRPIPTVAR AYPLVGHALL MKPDGRE--- 
CYP4X1h    ---------- ------RLLR DLRPFPAPPT -HWFLGHQKF IQ---DD--- 
CYP4Z1     ---------- ------WMIR ALHLFPAPPA -HWFYGHKEF YP---VK--- 
CYP5A1h    ---------- ------LEKL GLRHPKPSP- ---FIGNLTF FRQG------ 
CYP7A1h    ---------- ---------R QTGEPPLENG LIPYLGCALQ FGANPLE--- 
CYP7B1h    ---------- --------TR RPGEPPLIKG WLPYLGVVLN LRKDPLR--- 
CYP8A1h    ---------- --------TR RPGEPPLDLG SIPWLGYALD FGKDAAS--- 
CYP8B1h    ---------- --------QR RPWEPPLDKG TVPWLGHAMA FRKNMFE--- 
CYP11A1h   ---------- ------SPRP FNEIPSPGDN GWLNLYHFWR ETGTHKVH-- 
CYP11B1h   ---------- ------TVLP FEAMPRRPGN RWLRLLQIWR EQGYEDLH-- 
CYP11B2h   ---------- ------TVLP FEAMPQHPGN RWLRLLQIWR EQGYEHLH-- 
CYP17h     ---------- ------KRRC PGAKYPKSLL SLPLVGSLPF LPRHGHMH-- 
CYP19h     ---------- --LFLLVWNY EGTSSIPGPG YCMGIGPLIS HGRFLWMG-- 
CYP20h     ---------- ------GITP TEEKDGNLP- -------DIV NSGSLHE--- 
CYP21A2h   ---------- ------GARL LWNWWKLRSL HLPPLAPGFL HLLQPDLP-- 
CYP24h     -----VPVCP LTAGGETQNA AALPGPTSWP LLASLLQILW KGGLKKQH-- 
CYP26A1h   ---------- --------RS CALPLPPGTM GFPFFGETLQ MVLQRRK--- 
CYP26B1h   ---------- --------KS CKLPIPKGSM GFPLIGETGH WLLQGSG--- 
CYP26C1h   ---------- --------RA STLPLPKGSM GWPFFGETLH WLVQGSR--- 
CYP27A1h   ---------- ---PGVRRRQ RSLEEIPRLG QLRFFFQLFV QGYALQLH-- 
CYP27B1h   ---------- ---REYHSAR RSLADIPGPS TPSFLAELFC KGGLSRLH-- 
CYP27C1h   EDKGAGRPGS PPGGGRAEGP RSLAAMPGPR TLANLAEFFC RDGFSRIH-- 
CYP39A1h   ---------- --------RK NLRRPPCIKG WIPWIGVGFE FGKAPLE--- 
CYP46h     ---------- ------GPPR PSFLLGHLPC ---FWKKDEV GGRVLQD--- 
CYP51h     ---------- --------PA GVKSPPYIFS PIPFLGHAIA FGKSPIE--- 

Cyp1a1     ---------- ---------- LSLTRLSQQY GDVLQIRIGS T---PVVVLS 
Cyp1a2     ---------- ---------- LSLTRLSQQY GDVLQIRIGS T---PVVVLS 
Cyp1b1     ---------- ---------- LYFARLARRY GDVFQIRLGS C---PVVVLN 
Cyp2a4     ---------- ---------- NSLMKISQRY GPVFTIYLGS R---RIVVLC 
Cyp2a5     ---------- ---------- NSLMKISQRY GPVFTIYLGP R---RIVVLC 
Cyp2a12    ---------- ---------- SSITQLQEHY GPVFTIHLGP R---RVVVLY 
Cyp2a22    ---------- ---------- SSITQLQEHY GPVFTIHLGP R---RVVVLY 
Cyp2b9     ---------- ---------- KCFIQLQEKH GDVFTVHLGP R---PVVVLC 
Cyp2b10    ---------- ---------- KSFIQLREKY GDVFTVHLGP R---PVVMLC 
Cyp2b13    ---------- ---------- KCFIHLQEKH GDVFTVHLGP R---PVVVLC 
Cyp2b19    ---------- ---------- SSFIQLQEKY GDVFTVHLGP R---PVVMLC 
Cyp2b23    ---------- ---------- KSFIKLRDKH GDVFTVHLGP R---PVVMLY 
Cyp2c29    ---------- ---------- QSFTNFSKAY GPVFTLYLGS K---PTVILH 
Cyp2c37    ---------- ---------- QSFTNLSKVY GPVYTLYLGR K---PTVVLH 
Cyp2c38    ---------- ---------- QSLTNFSKAY GPVFTLYLGS R---PIVVLH 
Cyp2c39    ---------- ---------- QSLTNFSKAY GPVFTLYLGS R---PTVVLH 
Cyp2c40    ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH 
Cyp2c44    ---------- ---------- ASLSKLAKEY GPVYTLYFGS W---PTVVLH 
Cyp2c50    ---------- ---------- QSFTNLSKVY GPVYTLYLGN K---PTVVLH 
Cyp2c54    ---------- ---------- QSFTNLSRVY GPVYTLYLGR K---PTVVLH 
Cyp2c55    ---------- ---------- KSFNYFSKVY GPVFTLYFGS K---PTVVVH 
Cyp2c65    ---------- ---------- KSLRNFSKVY GPVFTLYLGR N---PAVVLH 
Cyp2c66    ---------- ---------- KSLRNFSKVY GPVFTLYLGK K---PAVVLH 
Cyp2c67    ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH 
Cyp2c68    ---------- ---------- QCLTNFSKIY GPVFTLYFGS Q---PIVILH 
Cyp2c69    ---------- ---------- QCLTNFSKTY GPVFTLYFGS Q---PIVVLH 
Cyp2c70    ---------- ---------- KSMGMLAKKY GPVFTVYLGM K---PTVVLH 
Cyp2ac1    ---------- ---------- ---------- ---------- ---------- 
Cyp2ab1    ---------- ---------- NMLFQLAQTH GSVFTVWLGS T---PIVVLS 
Cyp2d9     ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN 
Cyp2d10    ---------- ---------- YSLYKLQNRY GDVFSLQMGW K---PMVVIN 
Cyp2d34    ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PVVVIN 
Cyp2d11    ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN 
Cyp2d12    ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PMVVIN 
Cyp2d13    ---------- ---------- YSLYKLQNRY GDVFSLQMAW K---PVVVIS 
Cyp2d40    ---------- ---------- YSFYKLQNHY GDMFSLQMGW N---AMVIVN 
Cyp2d22    ---------- ---------- AGFQKLRGRY GDLFSLQLAS E---SVVVLN 
Cyp2d26    ---------- ---------- YSFYKLQNRY GNVFSLQMAW K---PVVVVN 
Cyp2e1     ---------- ---------- KSLTKLAKRF GPVFTLHLGQ R---RIVVLH 
Cyp2f2     ---------- ---------- TSLTKLSKEY GSVFTVYLGS R---PVIVLS 
Cyp2g1     ---------- ---------- QSFQKLQKKY GSVFTVYFGP R---PVVVLC 
Cyp2j5     ---------- ---------H LVLQQFVKKY GNVFSLELGQ S---PVVVVS 
Cyp2j6     ---------- ---------H LSIQPLVKKY GNIFSLNLGD I---TSVVIT 
Cyp2j7     ---------- --------LH LRIQLFVKKY GNLISIDFGN I---SSVVIT 
Cyp2j8     ---------- --------LH LGIQPFVKKY GNLISLDFGT I---PSVIIS 
Cyp2j9     ---------- ---------H LSLQQFVKKY GNVLSLDFAN I---PSVVIT 
Cyp2j13    ---------- ---------H LAVQKFVKKY GNVISLDFGI K---SAVIIS 
Cyp2j12    ---------- ---------H VVIQQFVKKY GNLTSLDFGN I---PSVIIT 
cyp2j11    ---------- --------LH LGIQPFVKKY GNVISVNFGY I---SSVIIS 
Cyp2r1     ---------- --------PH VYMRKQSRVY GEIFSLDLGG I---STVVLN 
Cyp2s1     ---------- ---------- SGLLRLSKKY GPVFTVYLGP W--RRVVVLV 
Cyp2t4     ---------- ---------- RVLMELSSHW GPVFTVWLGP L---PAVVLC 
Cyp2U1     FWLGS----- GSQTDTVGQH VYLARMARVY GNIFSFFIGH R---LVVVLS 
Cyp2w1     ---------- ---------- RALMELSERY GPMFTIHLGS Q---KTVVLS 
CYP2W1h    ---------- ---------- RSLMELSERY GPVFTVHLGR Q---KTVVLT 
Cyp3a11    ---------- --------LW KFDMECYKKY GKTWGLFDGQ --T-PLLAVT 
Cyp3a13    ---------- --------FW ECDIQCHKKY GKMWGLYDGR --Q-PVLAIT 
Cyp3a16    ---------- --------LW KFDMECYEKY GKTWGLFDGQ --I-PLFVIT 
Cyp3a25    ---------- --------MW KFDEDCYKKY GKIWGFYEGP --Q-PILAIM 
Cyp3a59    ---------- --------MW KFDEDCYKKY GKIWGFYVGP --K-PILAIM 
Cyp3a57    ---------- --------MW KFDDDCYKKY GKIWGFYEGP --Q-PILAIM 
Cyp3a41    ---------- --------LW KFDMECYEKY GKTWGLFDGQ --M-PLFVIT 
Cyp3a44    ---------- --------IW KFDMECYEKY GKTWGLFDGQ --T-PLLVIT 
Cyp4a10    ---------- --------EL QEIVSCIENF PSAFPRWFWG -SK-AYLTVY 
Cyp4a31    ---------- --------EL QEIVSCIENF PSAFPRWFWG -SK-AYLTVY 
Cyp4a32    ---------- --------EL KEVVSCIEHF PSAFPCWFWG -SN-AYLTVY 
Cyp4a12a   ---------- --------DL QDILTRIKNF PSACPQWLWG -SK-VRIQVY 
Cyp4a12b   ---------- --------DL QDILTRIKNF PSACPQWLWG -SK-VRIQVY 
Cyp4a14    ---------- --------EL QQILIWVEKF PSACLQCLSG -SN-IRVLLY 
Cyp4a30b   ---------- --------DL QQILLCVEKF PSTYVRWLWG -NH-ARVVIY 
Cyp4a29    ---------- --------EL RWILRYLEKF PGAFLHWIWG -SH-VFIKVC 
Cyp4b1     ---------- --------GL DKVVTWTEQF PYAHPLWLGQ -FI-VFLNIY 
Cyp4f13    ---------- --------SM QFITHLGHDF HDVHLSWVGP -VY-PILRLV 
Cyp4f14    ---------- --------GL KELTRLVGTY PQGFLMWIGP -MV-PVITLC 
Cyp4f15    ---------- --------GL KEVTNLVATY PQGFMTWLGP -II-PIITLC 
Cyp4f16    ---------- --------GM QLVTEMGQAF QDVHLFWLGP -VI-PVLRIV 
Cyp4f17    ---------- --------GL QLLTERSHQF HDVHLCWIGP -FY-PILRLI 
Cyp4f18    ---------- --------GL LYIQSLVRTF RDACCWWVGP -LH-PVIRIF 
Cyp4f37    ---------- --------GM QLMTEAGQTY RDVHLCWLGP -VI-PVLRIV 
Cyp4f39    ---------- --------GL QNEKKVLDTM HHIILAWVGP -FL-PLLVLV 
Cyp4f40    ---------- --------GM KQVTELVTTY PQGFMTWLGP -IV-PLITLC 
Cyp4v3     ---------- --------FF QQLIYYTEEF RHLPIIKLWI GPV-PLVALY 
Cyp4x1     ---------- --------NM ETLDEIVKKH PCAFPCWVGP -FQ-AFFYIY 
Cyp5a1     ---------- --------FW ESQLELRERY GPLCGYYLGR --R-MHVVIS 
Cyp7a1     ---------- ---------- -FLRAKQRKH GHVFTCKLMG K---YVHFIT 
Cyp7b1     ---------- ---------- -FLKTLQRQH GDTFTVFLVG K---YITFVL 
Cyp8a1     ---------- ---------- -FLTRMKEKH GDIFTVLVGG R---YVTVLL 
Cyp8b1     ---------- ---------- -FLKGMRAKH GDVFTVQLGG Q---YFTFVM 
Cyp11a1    ---------- ---------- YHQMQSFQKY GPIYREKLGT L---ESVYIV 
Cyp11b1    ---------- ---------- LEMHQVFREL GPIFRHSVGK T---QIVFVT 
Cyp11b2    ---------- ---------- LEMHQVFREL GPIFRHSVGK T---QIVSVM 
Cyp17      ---------- ---------- ANFFKLQEKY GPIYSLRLGT T---TAVIVG 
Cyp19      ---------- --------IG SACNYYNKMY GEFMRVWISG E--ETLIISK 
Cyp20      ---------- --------FL VNLHERYGPV V---SFWFGR RLV-VSLGTT 
Cyp21      ---------- ---------- IYLLGLTQKL GPIYRIRLGM Q---DVVVLN 
Cyp24      ---------- ---------- DTLAEYHKKY GQIFRMKLGS F---DSVHLG 
Cyp26a1    ---------- ---------- -FLQMKRRKY GFIYKTHLFG R---PTVRVM 
Cyp26b1    ---------- ---------- -FQSSRREKY GNVFKTHLLG R---PLIRVT 
Cyp26c1    ---------- ---------- -FHSSRRERY GTVFKTHLLG R---PVIRVS 
Cyp27a1    ---------- ---------- DLQVLNKTKY GPMWTTSFGT Y---TNVNLA 
Cyp27b1    ---------- ---------- ELQVHGAARY GPIWSGSFGT L---RTVYVA 
Cyp39      ---------- ---------- -FIEKARIKY GPVFTIFAMG N---RMTFVS 
Cyp46      ---------- --------VF LDWAKKYGPV VRVNVFYKTS VIV-TSPESV 
Cyp51      ---------- ---------- -FLENAYEKY GPVFSLTMVG K---TFTYLL 
CYP1A1h    ---------- ---------- LALSRMSQQY GDVLQIRIGS T---PVVVLS 
CYP1A2h    ---------- ---------- LALSRMSQRY GDVLQIRIGS T---PVLVLS 
CYP1B1h    ---------- ---------- LSFARLARRY GDVFQIRLGS C---PIVVLN 
CYP2A6     ---------- ---------- NSLMKISERY GPVFTIHLGP R---RVVVLC 
CYP2A7     ---------- ---------- DSIMKFSECY GPVFTIHLGP R---RVVVLC 
CYP2A13    ---------- ---------- NSLMKISERY GPVFTIHLGP R---RVVVLC 
CYP2B6     ---------- ---------- KSFLRFREKY GDVFTVHLGP R---PVVMLC 
CYP2C8     ---------- ---------- KSFTNFSKVY GPVFTVYFGM N---PIVVFH 
CYP2C9     ---------- ---------- KSLTNLSKVY GPVFTLYFGL K---PIVVLH 
CYP2C18    ---------- ---------- KSLTNFSKVY GPVFTVYFGL K---PIVVLH 
CYP2C19    ---------- ---------- KSLTNLSKIY GPVFTLYFGL E---RMVVLH 
CYP2D6     ---------- ---------- YCFDQLRRRF GDVFSLQLAW T---PVVVLN 
CYP2E1h    ---------- ---------- KSFTRLAQRF GPVFTLYVGS Q---RMVVMH 
CYP2F1     ---------- ---------- TSLTKLSKEY GSMYTVHLGP R---RVVVLS 
CYP2G2P    ---------- ---------- QSFMKLREKY SPVFTVYMGP R---PVVVLC 
CYP2J2     ---------- ---------H LEVQLFVKKY GNLFSLELGD I---SAVLIT 
CYP2R1h    ---------- --------PH VYMRKQSQVY GEIFSLDLGG I---STVVLN 
CYP2S1h    ---------- ---------- SGLMRLSKKY GPVFTIYLGP W--RPVVVLV 
CYP2T2P    ---------- ---------- RALHSLSGRW GRVFTVRLGP R---PAVGLC 
CYP2U1h    SWLSSRTRAA GIDPSVIGPQ VLLAHLARVY GSIFSFFIGH Y---LVVVLS 
CYP3A4     ---------- --------FC MFDMECHKKY GKVCGFYDGQ --Q-PVLAIT 
CYP3A5     ---------- --------LW KFDTECYKKY GKMWGTYEGQ --L-PVLAIT 
CYP3A7     ---------- --------YW TFDMECYKKY RKVWGIYDCQ --Q-PMLAIT 
CYP3A43    ---------- --------LW NFDRECNEKY GEMWGLYEGQ --Q-PMLVIM 
CYP4A11    ---------- --------EL QRIQKWVETF PSACPHWLWG -GK-VRVQLY 
CYP4A22    ---------- --------EL QRIQERVKTF PSACPYWIWG -GK-VRVQLY 
CYP4B1h    ---------- --------SL DKVVSWAHQF PYAHPLWFGQ -FI-GFLNIY 
CYP4F2     ---------- --------GL LYTQSLACTF GDMGCWWVGP -WQ-AVIHIF 
CYP4F3     ---------- --------GL LYTQSLACTF GDMCCWWVGP -WH-AIVRIF 
CYP4F8     ---------- --------GL RVLTQLVATY PQGFVRWLGP -IT-PIINLC 
CYP4F11    ---------- --------GM KTLTQLVTTY PQGFKLWLGP -TF-PLLILC 
CYP4F12    ---------- --------GL KDSTQMSATY SQGFTVWLGP -II-PFIVLC 
CYP4F22    ---------- --------GL QDEKKVLDNM HHVLLVWMGP -VL-PLLVLV 
CYP4F23P   ---------- --------DM RLMEDLGHYF RDVQLWWLGS -FY-PVLHLV 
CYP4V2     ---------- --------FF QQIIEYTEEY RHMPLLKLWV GPV-PMVALY 
CYP4X1h    ---------- --------NM EKLEEIIEKY PRAFPFWIGP -FQ-AFFCIY 
CYP4Z1     ---------- --------EF EVYHKLMEKY PCAVPLWVGP -FT-MFFSVH 
CYP5A1h    ---------- --------FW ESQMELRKLY GPLCGYYLGR --R-MFIVIS 
CYP7A1h    ---------- ---------- -FLRANQRKH GHVFTCKLMG K---YVHFIT 
CYP7B1h    ---------- ---------- -FMKTLQKQH GDTFTVLLGG K---YITFIL 
CYP8A1h    ---------- ---------- -FLTRMKEKH GDIFTILVGG R---YVTVLL 
CYP8B1h    ---------- ---------- -FLKRMRTKH GDVFTVQLGG Q---YFTFVM 
CYP11A1h   ---------- ---------- LHHVQNFQKY GPIYREKLGN V---ESVYVI 
CYP11B1h   ---------- ---------- LEVHQTFQEL GPIFRYDLGG A---GMVCVM 
CYP11B2h   ---------- ---------- LEMHQTFQEL GPIFRYNLGG P---RMVCVM 
CYP17h     ---------- ---------- NNFFKLQKKY GPIYSVRMGT K---TTVIVG 
CYP19h     ---------- --------IG SACNYYNRVY GEFMRVWISG E--ETLIISK 
CYP20h     ---------- --------FL VNLHERYGPV V---SFWFGR RLV-VSLGTV 
CYP21A2h   ---------- ---------- IYLLGLTQKF GPIYRLHLGL Q---DVVVLN 
CYP24h     ---------- ---------- DTLVEYHKKY GKIFRMKLGS F---ESVHLG 
CYP26A1h   ---------- ---------- -FLQMKRRKY GFIYKTHLFG R---PTVRVM 
CYP26B1h   ---------- ---------- -FQSSRREKY GNVFKTHLLG R---PLIRVT 
CYP26C1h   ---------- ---------- -FHSSRRERY GTVFKTHLLG R---PVIRVS 
CYP27A1h   ---------- ---------- QLQVLYKAKY GPMWMSYLGP Q---MHVNLA 
CYP27B1h   ---------- ---------- ELQVQGAAHF GPVWLASFGT V---RTVYVA 
CYP27C1h   ---------- ---------- EIQQKHTREY GKIFKSHFGP Q---FVVSIA 
CYP39A1h   ---------- ---------- -FIEKARIKY GPIFTVFAMG N---RMTFVT 
CYP46h     ---------- --------VF LDWAKKYGPV VRVNVFHKTS VIV-TSPESV 
CYP51h     ---------- ---------- -FLENAYEKY GPVFSFTMVG K---TFTYLL 

Cyp1a1     GLNTIKQALV RQGDDFKGRP D-LYSFTLIT NG---KSMTF NPDSGPVWAA 
Cyp1a2     GLNTIKQALV RQGDDFKGRP D-LYSFTLIT NG---KSMTF NPDSGPVWAA 
Cyp1b1     GESAIHQALV QQGSIFADRP P-FASFRVVS GG---RSLAF G-HYSEHWKT 
Cyp2a4     GQEAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGIAF S--SGERAKQ 
Cyp2a5     GQEAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGVVF S--SGERAKQ 
Cyp2a12    GYDAVKEALV DHAEEFSGRG E-QATFNTLF KG---YGVAF S--NGERAKQ 
Cyp2a22    GYDAVKEALE DNAEEFSGRG E-QATFNTLF KG---YGVTF S--NGERAKQ 
Cyp2b9     GTQTIREALV DHAEAFSGRG T-IAAAQLVM QD---YGIFF A--SGQRWKT 
Cyp2b10    GTDTIREALV GQAEAFSGRG T-VAVVEPTF KE---YGVIF A--NGERWKT 
Cyp2b13    GTQTIREALV NNAEAFSGRG T-IAAAQLVM QD---YGIFF S--SGERWKT 
Cyp2b19    GTDTIREALV NQAEAFSGRG T-VAVLDPIV QG---YGVIF S--SGERWKT 
Cyp2b23    GTETIKEALV DHSDAFSGRG A-IAVIQPIV QD---YGVIF S--SGERWKT 
Cyp2c29    GYEAVKEALI DRGEEFAGRG S-FPMAEKMI KG---FGVVF S--NGNRWKE 
Cyp2c37    GYEAVKEALV DHGEEFAGRG R-FPVFDKAT NG---MGLAF S--KGNVWKN 
Cyp2c38    GYEAVKEALI DHGEEFSGRG N-IPMSEKIN NG---LGITF S--NGNSWKE 
Cyp2c39    GYEAVKEALI DHGEEFSDRG S-IPMVEKIN NG---LGIVF S--NGNRWKE 
Cyp2c40    GYEAIKEALI DHGEEFSGRG R-IPVFDKVS TG---KGIGF S--HGNVWKA 
Cyp2c44    GYDVVKEALL NQGDEFLGRG P-LPIIEDSQ KG---HGIVF S--EGERWKL 
Cyp2c50    GYEAVKEALV DHGEEFAGRG R-LPVFDKAT NG---MGIIF S--KGNVWKN 
Cyp2c54    GYEAVKEALV DHGDVFAGRG R-LPVFDKAT NG---MGIGF S--NGSVWKN 
Cyp2c55    GYEAVKEALD DLGEEFSGRG S-FQIFERIN ND---LGVIF S--NGTKWKE 
Cyp2c65    GYEAVKEAFT DHGEEFAGRG V-FPVFDKFK KN---CGVVF S--SGRTWKE 
Cyp2c66    GYKAVKEALI DHGEEFAGRG T-FPVADKFI RV---LGVVF S--SGRTWKE 
Cyp2c67    GYEAMKEAFI DHGEEFSGRG R-FPFFDKVT KG---KGIGF S--HGNVWKA 
Cyp2c68    GYEAMKEAFI DYGEEFSGRG R-IPVFDKVS KG---KGIGF S--HGNVWKA 
Cyp2c69    GYEAIKEALI DHGEVFSGRG R-FPFFDKVS KG---KGIGF S--HGNVWKA 
Cyp2c70    GYKAMKEALI DQGDEFSDKT D-SSLLSRTS QG---LGIVF S--NGETWKQ 
Cyp2ac1    ---------- ---------- ---------- ------GIAY A--HGKCWKT 
Cyp2ab1    GFRAVKEALV SNSEQFSGRP L-TPFFRDLF GE---KGVIC S--NGLTWRQ 
Cyp2d9     GLKAMKEMLL TCGEDTADRP P-VPIFEYLG VKPGSQGVVL AP-YGPEWRE 
Cyp2d10    GLKAMKEVLL TCGEDTADRP Q-VPIFEYLG VKPGSQGVVL AP-YGPEWRE 
Cyp2d34    GLKAMQEVLL TCGKDTADHP P-VPIFEYLG FKSKSQGVVL AS-YGPEWRE 
Cyp2d11    GLKAMKEMLL TCGEDTADRP P-VPIFEYLG VKPGSQGVVL AP-YGPEWRE 
Cyp2d12    RMKAMKEVLL TCGEDTADRP P-VPIFEHLG FKPRSQGMIF AP-YGPEWRE 
Cyp2d13    GLKAVREVLV TCGEDTADRP E-MPIFQHLG YGEKAKGVVF AP-YGPEWRE 
Cyp2d40    GLKAVQEALV TCGEYTADRP E-MPIFPHLG YGQKDKGLVL AP-YGPEWQE 
Cyp2d22    GLTALREALV KHSEDTADRP P-LHFNDLLG FGPRSQGIVL AR-YGPAWRQ 
Cyp2d26    GLKAVRELLV TYGEDTSDRP L-MPIYNHIG YGHKSKGVIL AP-YGPEWRE 
Cyp2e1     GYKAVKEVLL NHKNEFSGRG D-IPVFQEYK N----KGIIF N--NGPTWKD 
Cyp2f2     GYQTVKEALV DKGEEFSGRG A-YPVFFNFT RG---NGIAF S--DGERWKI 
Cyp2g1     GHEAVKEALV DQADDFSGRG E-MPTLEKNF QG---YGLAL S--NGERWKI 
Cyp2j5     GLPLIKEMFT HLDQNFVNRF M-TPVRERIT GK---NGLVV S--NGQTWKE 
Cyp2j6     GLPLIKEALT QMEQNIMNRP L-SVMQERIS NK---NGLIF S--SGQIWKE 
Cyp2j7     GLPLIKEAFT DMEQNLLKRP I-IPSRKHVF KD---NGIIF S--SGQKWKE 
Cyp2j8     GEPLIKEALT CMGQNFLKRP I-LAARQHIF KN---NGIIS S--SGQTWKE 
Cyp2j9     GMPLIKEIFT QMEHNFMNRP V-TLLRKHLF NK---NGLIF S--SDQTWKE 
Cyp2j13    SLPLIKEAFS HLDENFINRR I-FPLQRQIF NG---NGLIF S--SGQTWKE 
Cyp2j12    GLPLIKEVFT NMEQNFLNRP I-TPIRKRVF NN---NGLII S--NGQTWKE 
cyp2j11    GLPLIKEAIT GMEQNFLKRP S-LAARQHVF KN---NGIVF S--SGQTWKE 
Cyp2r1     GYDVVKECLV HQSEIFADRP C-LPLFMKMT KM---GGLLN SR-YGRGWID 
Cyp2s1     GHDAVREALG GQAEEFSGRG T-LATLDKTF DG---HGVFF A--NGERWKQ 
Cyp2t4     GYEALRDALV LQADAFSGRG A-MAVFDRFT CG---NGIVF S--NGPRWHS 
Cyp2U1     DFHSVREALV QQAEVFSDRP R-MPLISIMT KE---KGIVF AH-YGPIWKQ 
Cyp2w1     GYEVVREALV GTGHELADRP P-IPIFQHIQ RG---GGIFF S--SGARWRA 
CYP2W1h    GFEAVKEALA GPGQELADRP P-IAIFQLIQ RG---GGIFF S--SGARWRA 
Cyp3a11    DPETIKNVLV KECFS---VF TNRRDFGPVG IM---SKAIS IS-KDDEWKR 
Cyp3a13    DPDIIKTVLV KECYS---TF TNRRRFGPVG IL---KKAIS IS-ENEEWKR 
Cyp3a16    DPETIKNVLV KECFS---VF TNRQDFFPVG IM---SKSIS LA-KDEEWKR 
Cyp3a25    DPEIIKIVLV KECYS---VF TNRRFFGPVG FM---KKAIT IS-EDEEWKR 
Cyp3a59    DPEIIKIVLV KECYS---VF TNRRLLGPVG FL---KKSIT IS-EDEEWKR 
Cyp3a57    DPEIIKIVLV KECYS---VF TNRRPFGPVG FL---KKSIT IS-EDEEWKR 
Cyp3a41    DPEMIKNVLV KECFS---VF TNRREFGPVG IM---SKAIS IS-KDEEWKR 
Cyp3a44    DPETIKNVLV KDCLS---VF TNRREFGPVG IM---SKAIS IS-KDEEWKR 
Cyp4a10    DPDYMKVILG RS----DPKA NGAYRLLAPW IG---YGLLL LN-G-QPWFQ 
Cyp4a31    DPDYMKVILG RS----DPKA NGAYRLLAPW IG---YGLLL LN-G-QSWFQ 
Cyp4a32    DPDYMKVILG RS----DPKA NGIYRLLAPW IG---YGLLL LN-G-QPWFQ 
Cyp4a12a   DPDYMKLILG RS----DPKA NGSYRFLAPW IG---RGLLM LD-G-QTWFQ 
Cyp4a12b   DPDYMKLILG RS----DPKA HGSYRFLAPW IG---RGLLL LD-G-QTWFQ 
Cyp4a14    DPDYVKVVLG RS----DPKA SGIYQFFAPW IG---YGLLL LN-G-KKWFQ 
Cyp4a30b   DPDYMKVILG RS----DPKV VRSYSFFAPW IG---YGLLL LN-G-KKWFQ 
Cyp4a29    DPDYMKVILG RA----SDPK ASLYRFLTPW LG---HGLFF LN-G-DEWFQ 
Cyp4b1     EPDYAKAVYS RG----DPKA AYVYDFFLQW IG---KGLLV LE-G-PKWFQ 
Cyp4f13    HPNFIAPLLQ AS-AAVAPKE MTLYGFLKPW LG---DGLLM SA-G-DKWSH 
Cyp4f14    HSDIVRSILN AS-AAVALKD VIFYSILKPW LG---DGLLV SA-G-DKWSR 
Cyp4f15    HPDIIRSVLN AS-ASVALKE VVFYSFLKPW LG---DGLLL SD-G-DKWSS 
Cyp4f16    DPAFVAPLLQ AP-ALVAPKD MTFLRFLKPW LG---DGLFL SS-G-DKWSR 
Cyp4f17    HPKFIGSILQ AS-AAVAPKE MIFYGFLKPW LG---DGLLV SA-G-EKWSR 
Cyp4f18    HPAFIKPVVL AP-ALVAPKD TVFYRFLKPW LG---DGLLM ST-G-DKWSR 
Cyp4f37    DPAFVAPLLL AT-ALVAPKD TTFHTFVKPW LG---DGLFL NS-G-DKWSR 
Cyp4f39    HPDYIKPVLG AS-AAIAPKD EFFYSFLKPW LG---DGLLI SK-G-NKWSR 
Cyp4f40    HPDIIRSVLS ASSAAVAPKD DIFYSFLKPW LG---DGLLV SA-G-DKWNR 
Cyp4v3     KAENVEVILT SS--K-QIDK SFLYKFLQPW LG---LGLLT ST-G-SKWRT 
Cyp4x1     DPDYAKIFLS RT----G--- ---------- -----RGLLN LD-G-PRWFQ 
Cyp5a1     EPDMIKQVLV ENFSN---FS NRMASGLEPK MV---ADSVL LL-RDRRWEE 
Cyp7a1     NSLSYHKVLC HGK-YFDWKK F-HYTTSAKA FG---HRSID PS-DGNTTEN 
Cyp7b1     NPFQYQYVTK NPK-QLSFQK F-SSRLSAKA FS---VKKLL TD-DDLNED- 
Cyp8a1     DPHSYDTVVW ELRTRLDFHP Y-AIFLMERI FD---LQLPN FN-PSEEKA- 
Cyp8b1     DPLSFGPIIK NTEKALDFQS Y-AKELVLKV FG---YQSVD GD-HRMIHL- 
Cyp11a1    DPKDASILFS CEGPNPERFL V-PPWVAYHQ YYQRPIGVLF K--SSDAWKK 
Cyp11b1    LPEDVEKLYQ VESTHPCRMP L-ESWIVHRE LRGLGRGVFL L--NGPEWYF 
Cyp11b2    LPEDAEKLHQ VESMLPRRMH L-EPWVAHRE LRGLRRGVFL L--NGPEWRL 
Cyp17      HYQLAREVLV KKGKEFSGRP Q-MVTLGLLS DQG--KGVAF AD-SSSSWQL 
Cyp19      SSSMFHVMKH SHYISRFGSK R-GLQCIGMH EN----GIIF NN-NPSLWRT 
Cyp20      DVLKQHFNPN KT---SDPFE TMLKSLLGYQ SG---GGSAG ED------HV 
Cyp21      SNRTIEEALI QKWVDFAGRP -----HMLNG KMD--LDLSL GD-YSLMWKA 
Cyp24      SPSLLEALYR TESAHPQRLE I-KPWKAYRD HRNEAYGLMI L--EGQEWQR 
Cyp26a1    GADNVRRILL GEH--RLVSV H-WPASVRTI LG---AGCLS NL-HDSSHKQ 
Cyp26b1    GAENVRKILL GEH--QLVST E-WPRSARVL LG---PNTVA NS-IGDIHRN 
Cyp26c1    GAENVRTILL GEH--RLVRS Q-WPQSAHIL LG---SHTLL GA-VGEPHRQ 
Cyp27a1    SAPLLEQVMR QEGKYPIRDH M-DQWKDHRD HKGLTYGIFI A--QGEQWYH 
Cyp27b1    DPTLVEQLLR QESHCPERCS F-SSWAEHRR RHQRACGLLT A--DGEEWQR 
Cyp39      EEEGINVLLK SEHVDFESAV Q-SPVYHTAW IP---KNVFS AL-HERLYAL 
Cyp46      KKFLMSTKYN KD---SKMYR ALQTVFGERL FG---QGLVS EC-DYGRWYK 
Cyp51      GSDAAALLFN SKNEDLNAEE V-YGRLTTPV FG---KGVAY DV-PNAIFLE 
CYP1A1h    GLDTIRQALV RQGDDFKGRP D-LYTFTLIS NG---QSMSF SPDSGPVWAA 
CYP1A2h    RLDTIRQALV RQGDDFKGRP D-LYTSTLIT DG---QSLTF STDSGPVWAA 
CYP1B1h    GERAIHQALV QQGSAFADRP A-FASFRVVS GG---RSMAF G-HYSEHWKV 
CYP2A6     GHDAVREALV DQAEEFSGRG E-QATFDWVF KG---YGVVF S--NGERAKQ 
CYP2A7     GHDAVREALV DQAEEFSGRG E-QATFEWVF KG---YGVAF S--NGERAKQ 
CYP2A13    GHDAVKEALV DQAEEFSGRG E-QATFDWLF KG---YGVAF S--NGERAKQ 
CYP2B6     GVEAIREALV DKAEAFSGRG K-IAMVDPFF RG---YGVIF A--NGNRWKV 
CYP2C8     GYEAVKEALI DNGEEFSGRG N-SPISQRIT KG---LGIIS S--NGKRWKE 
CYP2C9     GYEAVKEALI DLGEEFSGRG I-FPLAERAN RG---FGIVF S--NGKKWKE 
CYP2C18    GYEAVKEALI DHGEEFSGRG S-FPVAEKVN KG---LGILF S--NGKRWKE 
CYP2C19    GYEVVKEALI DLGEEFSGRG H-FPLAERAN RG---FGIVF S--NGKRWKE 
CYP2D6     GLAAVREALV THGEDTADRP P-VPITQILG FGPRSQGVFL AR-YGPAWRE 
CYP2E1h    GYKAVKEALL DYKDEFSGRG D-LPAFHAHR D----RGIIF N--NGPTWKD 
CYP2F1     GYQAVKEALV DQGEEFSGRG D-YPAFFNFT KG---NGIAF S--SGDRWKV 
CYP2G2P    GHEAVKEALV DQADEFSGRG E-LASIKQNF QG---HGVAL A--NGERWRI 
CYP2J2     GLPLIKEALI HMDQNFGNRP V-TPMREHIF KK---NGLIM S--SGQAWKE 
CYP2R1h    GYDVVKECLV HQSEIFADRP C-LPLFMKMT KM---GGLLN SR-YGRGWVD 
CYP2S1h    GQEAVREALG GQAEEFSGRG T-VAMLEGTF DG---HGVFF S--NGERWRQ 
CYP2T2P    GYAALRDALV LQADAVSGRG S-MAVFERFT RG---NGILF S--NRPCWWT 
CYP2U1h    DFHSVREALV QQAEVFSDRP R-VPLISIVT KE---KGVVF AH-YGPVWRQ 
CYP3A4     DPDMIKTVLV KECYS---VF TNRRPFGPVG FM---KSAIS IA-EDEEWKR 
CYP3A5     DPDVIRTVLV KECYS---VF TNRRSLGPVG FM---KSAIS LA-EDEEWKR 
CYP3A7     DPDMIKTVLV KECYS---VF TNRRPFGPVG FM---KNAIS IA-EDEEWKR 
CYP3A43    DPDMIKTVLV KECYS---VF TNQMPLGPMG FL---KSALS FA-EDEEWKR 
CYP4A11    DPDYMKVILG RS----DPKS HGSYRFLAPW IG---YGLLL LN-G-QTWFQ 
CYP4A22    DPDYMKVILG RS----DPKS HGSYKFLAPR IG---YGLLL LN-G-QTWFQ 
CYP4B1h    EPDYAKAVYS RG----DPKA PDVYDFFLQW IG---RGLLV LE-G-PKWLQ 
CYP4F2     LPTCIKPVLF AS-AAIAPKD KFFYSFLEPW LG---DGLLL SA-G-DKWSR 
CYP4F3     HPTYIKPVLF AP-AAIVPKD KVFYSFLKPW LG---DGLLL SA-G-EKWSR 
CYP4F8     HPDIVRSVIN TS-DAITDKD IVFYKTLKPW LG---DGLLL SV-G-DKWRH 
CYP4F11    HPDIIRPITS AS-AAVAPKD MIFYGFLKPW LG---DGLLL SG-G-DKWSR 
CYP4F12    HPDTIRSITN AS-AAIAPKD NLFIRFLKPW LG---EGILL SG-G-DKWSR 
CYP4F22    HPDYIKPLLG AS-AAIAPKD DLFYGFLKPW LG---DGLLL SK-G-DKWSR 
CYP4F23P   HPTFTAPVLQ AS-AAVALKD MSFYGFLKPW LG---DGLLI SA-G-DKWRW 
CYP4V2     NAENVEGILT SS--K-QIDK SSMYKFLEPW LG---LGLLT ST-G-NKWRS 
CYP4X1h    DPDYAKTLLS RT----DPKS QYLQKFSPPL LG---KGLAA LD-G-PKWFQ 
CYP4Z1     DPDYAKILLK RQ----DPKS AVSHKILESW VG---RGLVT LD-G-SKWKK 
CYP5A1h    EPDMIKQVLV ENFSN---FT NRMASGLEFK SV---ADSVL FL-RDKRWEE 
CYP7A1h    NPLSYHKVLC HGK-YFDWKK F-HFATSAKA FG---HRSID PM-DGNTTEN 
CYP7B1h    DPFQYQLVIK NHK-QLSFRV F-SNKLLEKA FS---ISQLQ KN-HDMNDE- 
CYP8A1h    DPHSYDAVVW EPRTRLDFHA Y-AIFLMERI FD---VQLPH YS-PSDEKA- 
CYP8B1h    DPLSFGPILK DTQRKLDFGQ Y-AKKLVLKV FG---YRSVQ GD-HEMIHS- 
CYP11A1h   DPEDVALLFK SEGPNPERFL I-PPWVAYHQ YYQRPIGVLL K--KSAAWKK 
CYP11B1h   LPEDVEKLQQ VDSLHPHRMS L-EPWVAYRQ HRGHKCGVFL L--NGPEWRF 
CYP11B2h   LPEDVEKLQQ VDSLHPCRMI L-EPWVAYRQ HRGHKCGVFL L--NGPEWRF 
CYP17h     HHQLAKEVLI KKGKDFSGRP Q-MATLDIAS NNR--KGIAF AD-SGAHWQL 
CYP19h     SSSMFHIMKH NHYSSRFGSK L-GLQCIGMH EK----GIIF NN-NPELWKT 
CYP20h     DVLKQHINPN KT---SDPFE TMLKSLLRYQ SG---GGSVS EN------HM 
CYP21A2h   SKRTIEEAMV KKWADFAGRP E-PLTYKLVS RNY--PDLSL GD-YSLLWKA 
CYP24h     SPCLLEALYR TESVP-QRLE I-KPWKAYRD YRKEGYGLLI L--EGEDWQR 
CYP26A1h   GADNVRRILL GDD--RLVSV H-WPASVRTI LG---SGCLS NL-HDSSHKQ 
CYP26B1h   GAENVRKILM GEH--HLVST E-WPRSTRML LG---PNTVS NS-IGDIHRN 
CYP26C1h   GAENVRTILL GEH--RLVRS Q-WPQSAHIL LG---SHTLL GA-VGEPHRR 
CYP27A1h   SAPLLEQVMR QEGKYPVRND M-ELWKEHRD QHDLTYGPFT T--EGHHWYQ 
CYP27B1h   APALVEELLR QEGPRPERCS F-SPWTEHRR CRQRACGLLT A--EGEEWQR 
CYP27C1h   DRDMVAQVLR AEGAAPQRAN M-ESWREYRD LRGRATGLIS A--EGEQWLK 
CYP39A1h   EEEGINVFLK SKKVDFELAV Q-NIVYRTAS IP---KNVFL AL-HEKLYIM 
CYP46h     KKFLMSTKYN KD---SKMYR ALQTVFGERL FG---QGLVS EC-NYERWHK 
CYP51h     GSDAAALLFN SKNEDLNAED V-YSRLTTPV FG---KGVAY DV-PNPVFLE 

Cyp1a1     RRRLAQNALK SFSIASDPTS ASSCYLEEHV SKEANYLVSK LQKVMAEVG- 
Cyp1a2     RRRLAQDALK SFSIASDPTS ASSCYLEEHV SKEANHLVSK LQKAMAEVG- 
Cyp1b1     QRRSAYSTMR AFSTRHPRSR G---LLEGHA LAEARELVAV LVRRCAGGA- 
Cyp2a4     LRSFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDS FRKTNGAF-- 
Cyp2a5     LRRFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDS FRKTNGAF-- 
Cyp2a12    LRRFSIATLR DFGMGKRG-- -----VEEHI QEEAGCLIKM LQGTCGAP-- 
Cyp2a22    LRRFSIATLK DFGLGKRG-- -----MEERI QEEAGCLIKM LQGTCGAP-- 
Cyp2b9     LRRFSLATMK EFGMGKRS-- -----VEERI KEEAQCLVEE LKKYQGVP-- 
Cyp2b10    LRRFSLATMR DFGMGKRS-- -----VEERI QEEAQCLVEE LRKSQGAP-- 
Cyp2b13    LRRFSLATMK EFGMGKRS-- -----VEERI KEEAQCLVEE LKKYQGAP-- 
Cyp2b19    LRRFSLATMR DFGMGKRS-- -----VEERI KEEAQCLVEE LKKYKGAP-- 
Cyp2b23    LRRFSLATMR DFGMGKRS-- -----VEERI KEEAQCLVEE LKKYEGAP-- 
Cyp2c29    MRRFTLMTLR NLGMGKRN-- -----IEDRV QEEAQCLVEE LRKTKGSP-- 
Cyp2c37    TRRFSLMTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- 
Cyp2c38    TRHFTLMTLR NLGMGKRN-- -----IEDRV REEAQCLVEE LRKTKGSP-- 
Cyp2c39    IRRFTLTTLR NLGMGKRN-- -----IEDRV QEEAQCLVEE LRKTKGSP-- 
Cyp2c40    TRVFTVNTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGSP-- 
Cyp2c44    LRRFSLMTLK NFGMGKRS-- -----LEERV QEEARCLVEE LHKTEAQP-- 
Cyp2c50    TRRFSLTTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- 
Cyp2c54    TRHFSLMTLR NLGMGKRS-- -----IEDRV QEEARCLVEE LRKTNGSP-- 
Cyp2c55    LRRFSIMTLR SFGMGKRS-- -----IEDRI QEEASCLVEE LRKANGSL-- 
Cyp2c65    MRRFSLMTLR NFGMGRRS-- -----IEDRI QEEARCLVDE LRKTKGEP-- 
Cyp2c66    MRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVDE LRKTKGVP-- 
Cyp2c67    TRVFTINTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGLP-- 
Cyp2c68    TRVFTVNTLR NLGMGKRT-- -----IETKV QEEAQWLMKE LKKTNGSP-- 
Cyp2c69    TRVFTVNTLR NLGMGKRT-- -----IENKV QEEAQWLMKE LKKTNGSP-- 
Cyp2c70    TRRFSLMVLR SMGMGKKT-- -----IEDRI QEEILYMLDA LRKTNGSP-- 
Cyp2ac1    MRRFSLTTLR NFLMGKRI-- -----IEDTI VTECQHLIQC FESHKGLV-- 
Cyp2ab1    QRRFCLTTLR ELGLGKQA-- -----LEVQL QHEAAELAKV FLQEEGRA-- 
Cyp2d9     QRRFSVSTLR NFGLGKKS-- -----LEDWV TKEANHLCDA FTAQAGQP-- 
Cyp2d10    QRRFSVSTLR NFGLGKKS-- -----LEDWV TKEARHLCDA FTAQAGQP-- 
Cyp2d34    QRQFSVSTLR NFGLGKKS-- -----LEEWV TKEAKHLCDA FTARAGQS-- 
Cyp2d11    QRRFSVSTLR NFGLGKKS-- -----LEEWV TKEARHLCDA FTAQAGQP-- 
Cyp2d12    QRRFSLSSLR NFGLGRKS-- -----LEEWV IKEAGHLCDA FTTQAGQY-- 
Cyp2d13    LRRFSVSTLR NLGLGKKS-- -----LEQWV TEEAGHLCDA FTAQAGSP-- 
Cyp2d40    QRRFSMSTMR NFGLGKKS-- -----LEQWV TEEAGHLCDA FTDQAGSP-- 
Cyp2d22    QRRFSVSTMH HFGLGKKS-- -----LEQWV TEEARCLCAA FADHTGHP-- 
Cyp2d26    QRRFSVSTLR DFGLSKKS-- -----LEQWV TEEAGHLCDA FTKEAEHP-- 
Cyp2e1     VRRFSLSILR DWGMGKQG-- -----NEARI QREAHFLVEE LKKTKGQP-- 
Cyp2f2     LRRFSVQILR NFGMGKRS-- -----IEERI LEEGSFLLEV LRKMEGKP-- 
Cyp2g1     LRRFSLTVLR NFGMGKRS-- -----IEERI QEEAGYLLEE LHKVKGAP-- 
Cyp2j5     QRRLALMALR NFGLGKKS-- -----LEERI QEETHHLVEA IREEGGQP-- 
Cyp2j6     QRRFALMTLR NFGLGKKS-- -----LEERM QEEASHLVEA IREEEGKP-- 
Cyp2j7     QRRFALMILK SFGLGKKS-- -----LEQRI QEEAYHLVKA MEEEKGQP-- 
Cyp2j8     QRRFTLMILK NFGLGKKS-- -----LEQRI QDEAHHLVEA IAEEKGRP-- 
Cyp2j9     QRRFALMTLR NFGLGKRS-- -----LEERI QEEAHYLVEA IRDEGGQP-- 
Cyp2j13    QRRFALMTLR NFGLGKKS-- -----LEHRI QEEASHLVEA IGEEEGQP-- 
Cyp2j12    QRRFALMTLK NFGLGKKS-- -----LEQRI QKEADCLVEA IGEEKGKP-- 
cyp2j11    QRKFALTILK NFGLGKKS-- -----LEQCI QEEAYHLVKA IGEEKGQP-- 
Cyp2r1     HRRLAVNSFH YFGSGQKS-- -----FESKI LEETWSLIDA IETYKGGP-- 
Cyp2s1     LRKFTLLALR DLGMGKRE-- -----GEELI QAEVQSLVEA FQKTEGRP-- 
Cyp2t4     LRNFALGVLR ELGVGRST-- -----IEDRI LEEAACVLDE FQATMGAP-- 
Cyp2U1     QRRFSHSTLR HFGLGKLS-- -----LEPRI IEEFAYVKEA MQKHGEAP-- 
Cyp2w1     GRQFTVRTLQ SLGVQQPS-- -----MVGKV LQELACLKGQ LDSYGGQP-- 
CYP2W1h    ARQFTVRALH SLGVGREP-- -----VADKI LQELKCLSGQ LDGYRGRP-- 
Cyp3a11    YRALLSPTFT SGKLKE---- -----MFPVI EQYGDILVKY LRQKAKKGKP 
Cyp3a13    IRALLSPTFT SGRLKE---- -----MFPII NQFTDVLVRN MRQGLGEGKP 
Cyp3a16    YRALLSPTFT SGNLKE---- -----MFPVI EQYGDILVKY LRQEAEKGKP 
Cyp3a25    LRTLLSPTFT SGKLKE---- -----MFPIM RQYGDILVRN LRREEEKGEP 
Cyp3a59    LRTLLSPTFT SGKLKE---- -----MFPIM RQYGDILVRN LRREEEKGEP 
Cyp3a57    LRTLLSPTFT SSKLKE---- -----MFPIM RQYGDILVRN LRREEEKEEP 
Cyp3a41    YRALLSPTFT SGKLKE---- -----MFPVI EQYGDILVKY LMQEAEKGKP 
Cyp3a44    YRALLSPTFT SGRLKE---- -----MFPVI EQYGDILVKY LRQEAEKGMP 
Cyp4a10    HRRMLTPAFH YDILKP---- -----YVKNM ADSIRLMLDK WERLADQDSS 
Cyp4a31    HRKMLTPAFH YDILKT---- -----YVKNM ADSIRLMLDK WERLAGQDSS 
Cyp4a32    HRRMLTPAFH YDILKP---- -----YVKNM ADSIRLMLDK WERLAGQDSS 
Cyp4a12a   HRRMLTPAFH YDILKP---- -----YTEIM ADSVRVMLDK WEQIVGQDST 
Cyp4a12b   HRRMLTPAFH YDILKP---- -----YTEIM ADSVHVMLDK WEQIVGQDST 
Cyp4a14    HRRMLTPAFH YDILKP---- -----YVKIM ADSVNIMLDK WEKLDGQDHP 
Cyp4a30b   HRRMLTPAFH YDILKP---- -----YVGIM VDSVHVMLDK WEQLVDQDCP 
Cyp4a29    HRRLLTPAFH YDILKP---- -----YVGIM ADSVQVMLEK WEQIACQDIT 
Cyp4b1     HRKLLTPGFH YDVLKP---- -----YVAIF AESTRVMLDK WEKKASENKS 
Cyp4f13    HRRLLTPAFH FDILKS---- -----YVKIF NKSVNIMHAK WQ-CLASKGT 
Cyp4f14    HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WQ-RLISDGS 
Cyp4f15    HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WQ-HLASGGS 
Cyp4f16    HRRLLTPAFH FDILKP---- -----YVKIF NQSVNIMHAK WK-HLSSEGS 
Cyp4f17    HRHLLTPAFH FDILKP---- -----YMKNF NKSVNIMHAK WQ-RLTTKGT 
Cyp4f18    HRRMLTPAFH FNILKP---- -----YVKVF NDSTNIMHAK WQ-RLASKGS 
Cyp4f37    HRRLLTPAFH FDILKP---- -----YVKIF NQSVNIMHAK WK-HLSSEGS 
Cyp4f39    HRRLLTPAFH FDILKP---- -----YMKIF NQCTNIMHAK WRRHLAEGSV 
Cyp4f40    HRRMLTPAFH FNILKP---- -----YVKIF NDSTNIMHAK WL-RLASGGS 
Cyp4v3     RRKMLTPTFH FTILEN---- -----FLDVM NEQANILVNK LEKHVNQEAF 
Cyp4x1     HRCLLTPAFH QDILKP---- -----CVDTM AHSVKVMLDK WEKMWTTQET 
Cyp5a1     VRGALMSSFS PEKLDE---- -----MTPLI SQACELLVAH LKRYAASRDA 
Cyp7a1     INKTFNKTLQ GDALCS---- -----LSEAM MQNLQSVMRP PGLPKSKSAV 
Cyp7b1     -VHRAYLLLQ GKPLDA---- -----LLETM IQEVKELFES ---QLLKITD 
Cyp8a1     -R--MKPTLM HRDLQA---- -----LTEAM YTNLRTVLLG --DSTEAGSG 
Cyp8b1     -A--STKHLM GQGLEE---- -----LNQAM LDSLSLVMLG PKGSSLGASS 
Cyp11a1    DRIVLNQEVM APGAIKNFVP ----LLEGVA QDFIKVLHRR IKQQN-SGNF 
Cyp11b1    NRLQLNPNVL SPKAVQKFVP ----LVDGIA RDFVDNLKKK MLESV-HGSF 
Cyp11b2    NRLRLNRNVL SPKAVQKFVP ----MVDMVA RDFLETLKEK VLQNA-RGSL 
Cyp17      HRKLVFSTFS LFRD-DQK-- -----LEKMI CQEANSLCDL ILTYDGES-- 
Cyp19      IRPFFMKALT GPGLVR---- -----MVEVC VESIKQHLDR LGEVTDTS-- 
Cyp20      RRKLYGDAVT ASLHSN---- -----FPLLL QLSEELLDKW LSYPETQHIP 
Cyp21      HKKLSRSALM LGMR--DS-- -----MEPLI EQLTQEFCER MRAQAGTP-- 
Cyp24      VRSAFQKKLM KPVEIMKLDK ----KINEVL ADFMGQIDEL RDERG---R- 
Cyp26a1    RKKVIMQAFS REALQC---- -----YVLVI AEEVSSCLEQ WLSCGER--- 
Cyp26b1    KRKVFSKIFS HEALES---- -----YLPKI QLVIQDTLRA WSSQPE---- 
Cyp26c1    RRKVLARVFS RSSLEQ---- -----FVPRL QGALRREVRS WCAAQR---- 
Cyp27a1    LRQALKQRLL KPDEAALYTD ----ALNEVI SDFITRLDQV RAESE-SGDQ 
Cyp27b1    LRSLLAPLLL RPQAAAGYAG ----TLDNVV RDLVRRLRRQ RGRGSGLPGL 
Cyp39      MKGKMGTFNT HHFTGP---- -----LTEEL HEQLEGLGTH G--------- 
Cyp46      QRKVMDLAFS RSSLVS---- -----LMETF NEKAEQLVEI LEAKADGQTP 
Cyp51      QKKIIKSGLN IAHFKQ---- -----YVPII EKEAKEYFQS -------WGE 
CYP1A1h    RRRLAQNGLK SFSIASDPAS STSCYLEEHV SKEAEVLIST LQELMAGPG- 
CYP1A2h    RRRLAQNALN TFSIASDPAS SSSCYLEEHV SKEAKALISR LQELMAGPG- 
CYP1B1h    QRRAAHSMMR NFFTRQPRSR Q---VLEGHV LSEARELVAL LVRGSADGA- 
CYP2A6     LRRFSIATLR DFGVGKRG-- -----IEERI QEEAGFLIDA LRGTGGAN-- 
CYP2A7     LLRFAIATLR DFGVGKRG-- -----IEERI QEESGFLIEA IRSTHGAN-- 
CYP2A13    LRRFSIATLR GFGVGKRG-- -----IEERI QEEAGFLIDA LRGTHGAN-- 
CYP2B6     LRRFSVTTMR DFGMGKRS-- -----VEERI QEEAQCLIEE LRKSKGAL-- 
CYP2C8     IRRFSLTNLR NFGMGKRS-- -----IEDRV QEEAHCLVEE LRKTKASP-- 
CYP2C9     IRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTKASP-- 
CYP2C18    IRRFCLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTNASP-- 
CYP2C19    IRRFSLMTLR NFGMGKRS-- -----IEDRV QEEARCLVEE LRKTKASP-- 
CYP2D6     QRRFSVSTLR NLGLGKKS-- -----LEQWV TEEAACLCAA FANHSGRP-- 
CYP2E1h    IRRFSLTTLR NYGMGKQG-- -----NESRI QREAHFLLEA LRKTQGQP-- 
CYP2F1     LRQFSIQILR NFGMGKRS-- -----IEERI LEEGSFLLAD VRKTEGEP-- 
CYP2G2P    LR-FPLTILR DFGMGKRS-- -----IEERI QEEASYLLEE FRKTKGAP-- 
CYP2J2     QRRFTLTALR NFGLGKKS-- -----LEERI QEEAQHLTEA IKEENGQP-- 
CYP2R1h    HRRLAVNSFR YFGYGQKS-- -----FESKI LEETKFFNDA IETYKGRP-- 
CYP2S1h    LRKFTMLALR DLGMGKRE-- -----GEELI QAEARCLVET FQGTEGRP-- 
CYP2T2P    LRNFALGALK KFGLGTRT-- -----VEARV LEEAACLLDE FQATIGAP-- 
CYP2U1h    QRKFSHSTLR HFGLGKLS-- -----LEPKI IEEFKYVKAE MQKHGEDP-- 
CYP3A4     LRSLLSPTFT SGKLKE---- -----MVPII AQYGDVLVRN LRREAETGKP 
CYP3A5     IRSLLSPTFT SGKLKE---- -----MFPII AQYGDVLVRN LRREAEKGKP 
CYP3A7     IRSLLSPTFT SGKLKE---- -----MVPII AQYGDVLVRN LRREAETGKP 
CYP3A43    IRTLLSPAFT SVKFKE---- -----MVPII SQCGDMLVRS LRQEAENSKS 
CYP4A11    HRRMLTPAFH YDILKP---- -----YVGLM ADSVRVMLDK WEELLGQDSP 
CYP4A22    HRRMLTPAFH NDILKP---- -----YVGLM ADSVRVMLDK WEELLGQDSP 
CYP4B1h    HRKLLTPGFH YDVLKP---- -----YVAVF TESTRIMLDK WEEKAREGKS 
CYP4F2     HRRMLTPAFH FNILKP---- -----YMKIF NESVNIMHAK WQ-LLASEGS 
CYP4F3     HRRMLTPAFH FNILKP---- -----YMKIF NESVNIMHAK WQ-LLASEGS 
CYP4F8     HRRLLTPAFH FNILKP---- -----YIKIF SKSANIMHAK WQ-RLAMEGS 
CYP4F11    HRRMLTPAFH FN-LKP---- -----YMKIF NKSVNIMHDK WQ-RLASEGS 
CYP4F12    HRRMLTPAFH FNILKS---- -----YITIF NKSANIMLDK WQ-HLASEGS 
CYP4F22    HRRLLTPAFH FDILKP---- -----YMKIF NQSADIMHAK WR-HLAEGSA 
CYP4F23P   HRHLLTPAFH FKILKP---- -----YVKIF NESTNIMHAK WQ-RLALEGS 
CYP4V2     RRKMLTPTFH FTILED---- -----FLDIM NEQANILVKK LEKHINQEAF 
CYP4X1h    HRRLLTPGFH FNILKA---- -----YIEVM AHSVKMMLDK WEKICSTQDT 
CYP4Z1     HRQIVKPGFN ISILKI---- -----FITMM SESVRMMLNK WEEHIAQNSR 
CYP5A1h    VRGALMSAFS PEKLNE---- -----MVPLI SQACDLLLAH LKRYAESGDA 
CYP7A1h    INDTFIKTLQ GHALNS---- -----LTESM MENLQRIMRP PVSSNSKTAA 
CYP7B1h    -LHLCYQFLQ GKSLDI---- -----LLESM MQNLKQVFEP ---QLLKTTS 
CYP8A1h    -R--MKLTLL HRELQA---- -----LTEAM YTNLHAVLLG --DATEAGSG 
CYP8B1h    -A--STKHLR GDGLKD---- -----LNETM LDSLSFVMLT SKGWSLDASC 
CYP11A1h   DRVALNQEVM APEATKNFLP ----LLDAVS RDFVSVLHRR IKKAG-SGNY 
CYP11B1h   NRLRLNPEVL SPNAVQRFLP ----MVDAVA RDFSQALKKK VLQNA-RGSL 
CYP11B2h   NRLRLNPDVL SPKAVQRFLP ----MVDAVA RDFSQALKKK VLQNA-RGSL 
CYP17h     HRRLAMATFA LFKDGDQK-- -----LEKII CQEISTLCDM LATHNGQS-- 
CYP19h     TRPFFMKALS GPGLVR---- -----MVTVC AESLKTHLDR LEEVTNES-- 
CYP20h     RKKLYENGVT DSLKSN---- -----FALLL KLSEELLDKW LSYPETQHVP 
CYP21A2h   HKKLTRSALL LGIR--DS-- -----MEPVV EQLTQEFCER MRAQPGTP-- 
CYP24h     VRSAFQKKLM KPGEVMKLDN ----KINEVL ADFMGRIDEL CDERG---H- 
CYP26A1h   RKKVIMRAFS REALEC---- -----YVPVI TEEVGSSLEQ WLSCGER--- 
CYP26B1h   KRKVFSKIFS HEALES---- -----YLPKI QLVIQDTLRA WSSHPE---- 
CYP26C1h   RRKVLARVFS RAALER---- -----YVPRL QGALRHEVRS WCAAGG---- 
CYP27A1h   LRQALNQRLL KPAEAALYTD ----AFNEVI DDFMTRLDQL RAESA-SGNQ 
CYP27B1h   LRSLLAPLLL RPQAAARYAG ----TLNNVV CDLVRRLRRQ RGRGTGPPAL 
CYP27C1h   MRSVLRQRIL KPKDVAIYSG ----EVNQVI ADLIKRIYLL RSQAE-DGET 
CYP39A1h   LKGKMGTVNL HQFTGQ---- -----LTEEL HEQLENLGTH G--------- 
CYP46h     QRRVIDLAFS RSSLVS---- -----LMETF NEKAEQLVEI LEAKADGQTP 
CYP51h     QKKMLKSGLN IAHFKQ---- -----HVSII EKETKEYFES -------WGE 

Cyp1a1     H--FDPYKYL VVSVANVICA ICFGQRYDHD DQE---LLSI VNLSNEFGEV 
Cyp1a2     H--FEPVSQV VESVANVIGA MCFGKNFPRK SEE---MLNI VNNSKDFVEN 
Cyp1b1     F--LDPTQPV IVAVANVMSA VCFGCRYNHD DAE---FLEL LSHNEEFGRT 
Cyp2a4     ---IDPTFYL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGSLQF 
Cyp2a5     ---IDPTFYL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGSFQF 
Cyp2a12    ---IDPTIYL SKTASNVISS IVFGDRFNYE DKE---FLSL LQMMGQVNKF 
Cyp2a22    ---IDPTMYL SKTVSNVISS IVFGDRFNYE DKE---FLSL LQMMSQMNQF 
Cyp2b9     ---LDPTFLF QCITANIICS IVFGERFDYT DDQ---FLHL LNLMYKIFSL 
Cyp2b10    ---LDPTFLF QCITANIICS IVFGERFEYT DRQ---FLRL LELFYQTFSL 
Cyp2b13    ---LDPTFFF QCVTANIICS IVFGERFDYT DEQ---FLRL LNLMYQIYSL 
Cyp2b19    ---LNPTFYF QCIVANIICS IVFGERFDYK DHQ---FLHL LNLIYQTFSL 
Cyp2b23    ---LDPTFLF QCITANIICS IVFGERFDYT DHQ---FLHL LDLFYQTLSL 
Cyp2c29    ---CDPTFIL SCAPCNVICS IIFQNRFDYK DKE---FLIL MDKINENVKI 
Cyp2c37    ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL MEKLNEITKI 
Cyp2c38    ---CDPTFIL SCAPCNVICS IIFQDRFHYK DKD---FLML MKKLNENVKI 
Cyp2c39    ---CDPTFIL SCAPCNVICS IIFQDRFDYK DKD---FLML MEKLNENVKI 
Cyp2c40    ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c44    ---FDPTFIL ACAPCNVICS ILFNERFPYN DKT---FLNL MDLLNKNFYQ 
Cyp2c50    ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL MEKLNEITKI 
Cyp2c54    ---CDPTFIL GCAPCNVICS IIFQDRFDYK DRD---FLNL LEKLDEISKI 
Cyp2c55    ---CDPTFIL SCAPSNVICS VIFHNRFDYK DEK---FLNL MERLNENFKI 
Cyp2c65    ---CDPTFIL GCAPCNVICS IVFQNRFDYK DQE---FLTF LDILNENVEI 
Cyp2c66    ---CDPTFIL GCAPCNVICS IVFQNRFDYK DQE---FLTF IDILNENVEI 
Cyp2c67    ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c68    ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c69    ---CDPQFII GCAPCNVICS IVFQNRFDYK DKD---FLSL IGKVNECTEI 
Cyp2c70    ---CDPSFLL ACVPCNVIST VIFQHRFDYN DQT---FQDF MENFHRKIEI 
Cyp2ac1    ---LGM-RLL KASIANVIVS VLLGKWFDYQ DSQ---FLRL LTLIGENMKL 
Cyp2ab1    ---FDPQIPI IRSTTRVIGT LVFGHHFLSE EPI---FLEL IQAINLGLAF 
Cyp2d9     ---INPNPML NKSTCNVIAS LIFARRFEYE DPF---LIRM LKVLEQSLTE 
Cyp2d10    ---INPNTML NNAVCNVIAS LIFARRFEYE DPY---LIRM QKVLEDSLTE 
Cyp2d34    ---INPNTML NNAVCNVIAS LIFARRFEYE DPF---LIRM LKMREESLKE 
Cyp2d11    ---INPNPML NKSTCNVIAS LIFARRFEYE DPF---LIRM LKMLKECFTE 
Cyp2d12    ---INPNTML KKATCNVIAS LIFARRFEYE DPY---LIRM LKVLEDSLTE 
Cyp2d13    ---LDPYTLL NKAVCNVIAS LIYARRFEYG DPD---FIKM LKILKENMGE 
Cyp2d40    ---LNPYTLL NKAVCNVIAS LIYAHRFKYK DPD---FIKM LKVLKENTRE 
Cyp2d22    ---FSPNTLL DKAVCNVIAS LLYACRFEYD DPR---FIRL LGLLKETLKE 
Cyp2d26    ---FNPSPLL SKAVSNVIAS LIYARRFEYE DPF---FNRM LKTLKESLGE 
Cyp2e1     ---FDPTFLI GCAPCNVIAD ILFNKRFDYD DKK---CLEL MSLFNENFYL 
Cyp2f2     ---FDPVFIL SRSVSNIICS VVFGSRFDYD DER---LLTI XHFINDNFKI 
Cyp2g1     ---IDPTLYL SRTVSNVICS VVFGKRFDYQ DQR---FQSL MRMINESFVE 
Cyp2j5     ---FNPHLKL INAVSNIICS VTFGERFDYE DCQ---FQEL LQLLDETMHL 
Cyp2j6     ---FNPHFSI NNAVSNIICS VTFGERFDYH DSR---FQEM LRLLDEVMYL 
Cyp2j7     ---FDPHFRI NSAVSNIICS INFGERFEYG DNK---FQEL LKITNETLSA 
Cyp2j8     ---FDPHFMI NNAVSNIICS ITIGERFEYE DNQ---FQEL LKLADETLCL 
Cyp2j9     ---FDPHFNI SNAVSNIICS ITFGERFDYH DSQ---FQEM LRLLDEAMCL 
Cyp2j13    ---FDPHFKI YSAVSNIICS ITFGERFEYH DSQ---FQEL LQLLDKAMYL 
Cyp2j12    ---FDPHFKI NSAVSNIICT FAFGERFEYE DSH---FHEL LRLLDEATCL 
cyp2j11    ---FDPHFRI NNAVGNIICS IIFGERFEYD DNQ---FQEL LKLADEIICS 
Cyp2r1     ---FDLKQLI TNAVSNITNL ILFGERFTYE DTD---FQHM IELFSENVEL 
Cyp2s1     ---FNPSMLL AQATSNVVCS LVFGIRLPYD DKE---FQAV IQAASGTLLG 
Cyp2t4     ---FDPQQLL DSAVSNVICT VVFGKRYDYG DPE---FRRL LNLFSDNFCI 
Cyp2U1     ---FSPFPII SNAVSNIICS LCFGQRFDYT NKE---FKKV LDFMSRGLEI 
Cyp2w1     ---LP-LALL GWAPCNITFT LLFGQRFDYQ DPV---FVSL LSLIDQVMVL 
CYP2W1h    ---FP-LALL GWAPSNITFA LLFGRRFDYR DPV---FVSL LGLIDEVMVL 
Cyp3a11    ---VTMKDVL GAYSMDVITS TSFGVNVDSL NNP------- ----EDPFVE 
Cyp3a13    ---TSMKDIF GAYSMDVITA TSFGVNIDSL NNP------- ----QDPFVE 
Cyp3a16    ---VAVKDVL GAYSMDVIIS TTFGVNIDSL NNP------- ----EDPFVE 
Cyp3a25    ---ISMKDIF GAYSMDVITG TSFGVNVDSL NNP------- ----QDPFVQ 
Cyp3a59    ---INMKEIF GAYSMDVITG TSFGVNIDSL NNP------- ----QNPFVQ 
Cyp3a57    ---INMKDIF GAYSMDVITG TSCGVNIDSL NNP------- ----QDPFVQ 
Cyp3a41    ---VTMKDVL GAYSIDVITS TSFGVNVDSL NNP------- ----EDPFVE 
Cyp3a44    ---VAMKDVL GAYSMDVITS TSFGVNVDSL NNP------- ----EDPFVE 
Cyp4a10    ---IEIFQHI SLMTLDTVMK CAFSHKGSVQ VDG--NYRTY LQAIGDLNNL 
Cyp4a31    ---IEIFQHI SLMTLDTVMK CAFSHKGSVQ VD---NYKTY LQAIGDLNNL 
Cyp4a32    ---IEIFQHI SLMTLDTVMK CAFSHKGSVQ VD---NYKTY LQAIGDLNNL 
Cyp4a12a   ---LEIFRHI TLMTLDTIMK CAFSHEGSVQ LDR--KYKSY IQAVEDLNDL 
Cyp4a12b   ---LEIFQHI TLMTLDTIMK CAFSHEGSVQ LDR--KYKSY IQAVEDLNNL 
Cyp4a14    ---LEIFHCV SLMTLDTVMK CAFSYQGSVQ LDE--NSKLY TKAVEDLNNL 
Cyp4a30b   ---LEIYQDI SLMTMETMMK CAFSYQGSVQ LE---NSKSY IKAVEDLTHL 
Cyp4a29    ---LEIFHPI SLMMLDTIMK YAFSYQGSVQ LDRSRSSQAY LQAVSDLNNL 
Cyp4b1     ---FDIFCDV GHMALDTLMK CTFGKGDSGL SHS---DNSY YLAVSDLTLL 
Cyp4f13    S-RLDMFEHI SLMTLDSLQK CIFSVDSNCQ ESD----SKY IAAILELSSL 
Cyp4f14    A-RLDMFEHV SLMTLDSLQK CVFSFDSNCQ EKS----SEY IAAILELSAL 
Cyp4f15    A-RLDVFENI SLMTLDSLQK CVFSFDSNCQ ENP----SEY ISAILELSAL 
Cyp4f16    A-RLEMFEHI SLMTLDSLQK CLFGFDSNCQ ESP----SEY ISAILELSSL 
Cyp4f17    A-CLDMLEHI SLMTLDSLQN CVFSFDSNCQ ESP----SEY IAAIQELSSL 
Cyp4f18    A-YLNMFEHI SLMTLDSLQK CVFSFDSNCQ EKP----SEY ITAILELSAL 
Cyp4f37    A-RLEMFEHI SLMTLDSLQK CLFGFDSNCQ ESP----SEY ISAILELSSL 
Cyp4f39    T-SFDMFEHI SLMTLDSLQK CVFSYNSDCQ ESM----SDY ISSIIELSAL 
Cyp4f40    T-RLNMFENI SLMTLDTLQK CVFSFNSNCQ EKP----SQY IAAILELSTL 
Cyp4v3     N----CFFYI TLCALDIICE TAMGKNIGAQ SNN---DSEY VRTVYRMSDM 
Cyp4x1     T--IEVFEHI NLMTLDIIMK CAFGQETNCQ INS--TYESY VKATFELGEI 
Cyp5a1     F-NIQRCYC- -CYTIDVVAS VAFGTQVDSQ NSP------- ----EDPFVQ 
Cyp7a1     WVTEGMYAFC YRVMFEAGYL TLFGKDISK- ---------- --TDTQRAFI 
Cyp7b1     WNTERIFAFC GSLVFEITFA TLYGKILAG- ---------- --NKKQ--II 
Cyp8a1     WQETGLLEFS YNALLSAGYL TLYGVEASPR THE------- S-QAQDRVHS 
Cyp8b1     WCEDGLFHFC YRILFKAGFL SLFGYTKD-- ---------- --KQQDLDEA 
Cyp11a1    S--GVISDDL FRFSFESISS VIFGERMGML EEI---VDPE AQRFINAVY- 
Cyp11b1    S--MDFQSSV FNYTIEASHF VLFGERLGLI GRD---LSPD SLKFLHTLH- 
Cyp11b2    T--MDVQQSL FNYTIEASNF ALFGERLGLL GHD---LSPG SLKFIHALH- 
Cyp17      ---RDLSTLI FKSVINIICT ICFNISFENK DPI---LTTI QTFTEGIVDV 
Cyp19      ---GYVDVLT LMRHIMLDTS NMLFLGIPLD ESA---IVKK IQGYFNAWQA 
Cyp20      ---LS-QHML GFALKFVTRM VLG----STF EDE----QEV IRFQKIHGTV 
Cyp21      ---VAIHKEF SFLTCSIISC LTFGD---KD STL---VQTL HDCVQDLLQA 
Cyp24      I--QDLYSEL NKWSFESICL VLYEKRFGLL QKD---TEEE ALTFIAAIK- 
Cyp26a1    --GLLVYPEV KRLMFRIAMR ILLGCEPGPA G--------- --GGEDEQQL 
Cyp26b1    --AINVYQEA QRLTFRMAVR VLLGFSIPEE ---------- -----DLGHL 
Cyp26c1    --PVAVYQAA KALTFRMAAR ILLGLQLDEA ---------- -----RCTEL 
Cyp27a1    V--PDMAHLL YHLALEAITY ILFEKRIGCL KPS---IPED TAAFIRSVA- 
Cyp27b1    V--LDVAGEF YKFGLESIGA VLLGSRLGCL EAE---VPPD TETFIHAVG- 
Cyp39      --TMDLNDFV RYLLYPATLN TLFKKGLFLT ---------- --DKRTIKEF 
Cyp46      ---VSMQDML TCATIDILAK AAFGMETSML LGA----QKP LSQAVKVMLE 
Cyp51      SGERNVFEAL SELIILTASH CLHGKEIRS- --Q------- L-NEKVAQLY 
CYP1A1h    H--FNPYRYV VVSVTNVICA ICFGRRYDHN HQE---LLSL VNLNNNFGEV 
CYP1A2h    H--FDPYNQV VVSVANVIGA MCFGQHFPES SDE---MLSL VKNTHEFVET 
CYP1B1h    F--LDPRPLT VVAVANVMSA VCFGCRYSHD DPE---FREL LSHNEEFGRT 
CYP2A6     ---IDPTFFL SRTVSNVISS IVFGDRFDYK DKE---FLSL LRMMLGIFQF 
CYP2A7     ---IDPTFFL SRTVSNVISS IVFGDRFDYE DKE---FLSL LSMMLGIFQF 
CYP2A13    ---IDPTFFL SRTVSNVISS IVFGDRFDYE DKE---FLSL LRMMLGRFQF 
CYP2B6     ---MDPTFLF QSITANIICS IVFGKRFHYQ DQE---FLKM LNLFYQTFSL 
CYP2C8     ---CDPTFIL GCAPCNVICS VVFQKRFDYK DQN---FLTL MKRFNENFRI 
CYP2C9     ---CDPTFIL GCAPCNVICS IIFHKRFDYK DQQ---FLNL MEKLNENIKI 
CYP2C18    ---CDPTFIL GCAPCNVICS VIFHDRFDYK DQR---FLNL MEKFNENLRI 
CYP2C19    ---CDPTFIL GCAPCNVICS IIFQKRFDYK DQQ---FLNL MEKLNENIRI 
CYP2D6     ---FRPNGLL DKAVSNVIAS LTCGRRFEYD DPR---FLRL LDLAQEGLKE 
CYP2E1h    ---FDPTFLI GCAPCNVIAD ILFRKHFDYN DEK---FLRL MYLFNENFHL 
CYP2F1     ---FDPTFVL SRSVSNIICS VLFGSRFDYD DER---LLTI IRLINDNFQI 
CYP2G2P    ---IDPIFLL SRTVSNVISS VVFRSRFDYE DKQ---FLNL LRLINESFIE 
CYP2J2     ---FDPHFKI NNAVSNIICS ITFGERFEYQ DSW---FQQL LKLLDEVTYL 
CYP2R1h    ---FDFKQLI TNAVSNITNL IIFGERFTYE DTD---FQHM IELFSENVEL 
CYP2S1h    ---FDPSLLL AQATSNVVCS LLFGLRFSYE DKE---FQAV VRAAGGTLLG 
CYP2T2P    ---FDPVRLL DNAVSNVICS LVFGNRYRYG DPE---FLRL LNLFSDNFCI 
CYP2U1h    ---FCPFSII SNAVSNIICS LCFGQRFDYT NSE---FKKM LGFMSRGLEI 
CYP3A4     V-TLKDVFG- -AYSMDVITS TSFGVNIDSL NNP------- ----QDPFVE 
CYP3A5     V-TLKDIFG- -AYSMDVITG TSFGVNIDSL NNP------- ----QDPFVE 
CYP3A7     V-TLKHVFG- -AYSMDVITS TSFGVSIDSL NNP------- ----QDPFVE 
CYP3A43    I-NLKEDFFG -AYTMDVITG TLFGVNLDSL NNP------- ----QDPFLK 
CYP4A11    ---LEVFQHV SLMTLDTIMK CAFSHQGSIQ VDR--NSQSY IQAISDLNNL 
CYP4A22    ---LEVFQHV SLMTLDTIMK SAFSHQGSIQ VDR--NSQSY IQAISDLNSL 
CYP4B1h    ---FDIFCDV GHMALNTLMK CTFGRGDTGL GHR---DSSY YLAVSDLTLL 
CYP4F2     A-CLDMFEHI SLMTLDSLQK CVFSFDSHCQ EKP----SEY IAAILELSAL 
CYP4F3     A-RLDMFEHI SLMTLDSLQK CVFSFDSHCQ EKP----SEY IAAILELSAL 
CYP4F8     T-CLDVFEHI SLMTLDSLQK CIFSFDSNCQ EKP----SEY ITAIMELSAL 
CYP4F11    A-RLDMFEHI SLMTLDSLQK CVFSFESNCQ EKP----SEY IAAILELSAF 
CYP4F12    S-RLDMFEHI SLMTLDSLQK CIFSFDSHCQ ERP----SEY IATILELSAL 
CYP4F22    V-SLDMFEHI SLMTLDSLQK CVFSYNSNCQ EKM----SDY ISAIIELSAL 
CYP4F23P   V-RLEMFEHI SLMTLDSLQK CIFSFDSNCQ EKP----SEY IDAILELSAL 
CYP4V2     N----CFFYI TLCALDIICE TAMGKNIGAQ SND---DSEY VRAVYRMSEM 
CYP4X1h    S--VEVYEHI NSMSLDIIMK CAFSKETNCQ TNS--THDPY AKAIFELSKI 
CYP4Z1     ---LELFQHV SLMTLDSIMK CAFSHQGSIQ LD----RSSY LKAVFNLSKI 
CYP5A1h    F-DIQRCYC- -NYTTDVVAS VPFGTPVDSW QAP------- ----EDPFVK 
CYP7A1h    WVTEGMYSFC YRVMFEAGYL TIFGRDLTR- ---------- --RDTQKAHI 
CYP7B1h    WDTAELYPFC SSIIFEITFT TIYGKVIVC- ---------- --DNNK--FI 
CYP8A1h    WHEMGLLDFS YSFLLRAGYL TLYGIEALPR THE------- S-QAQDRVHS 
CYP8B1h    WHEDSLFRFC YYILFTAGYL SLFGYTKD-- ---------- --KEQDLLQA 
CYP11A1h   S--GDISDDL FRFAFESITN VIFGERQGML EEV---VNPE AQRFIDAIY- 
CYP11B1h   T--LDVQPSI FHYTIEASNL ALFGERLGLV GHS---PSSA SLNFLHALE- 
CYP11B2h   T--LDVQPSI FHYTIEASNL ALFGERLGLV GHS---PSSA SLNFLHALE- 
CYP17h     ---IDISFPV FVAVTNVISL ICFNTSYKNG DPE---LNVI QNYNEGIIDN 
CYP19h     ---GYVDVLT LLRRVMLDTS NTLFLRIPLD ESA---IVVK IQGYFDAWQA 
CYP20h     ---LS-QHML GFAMKSVTQM VMG----STF EDD----QEV IRFQKNHGTV 
CYP21A2h   ---VAIEEEF SLLTCSIICY LTFGDKI-KD DNL---MPAY YKCIQEVLKT 
CYP24h     V--EDLYSEL NKWSFESICL VLYEKRFGLL QKN---AGDE AVNFIMAIK- 
CYP26A1h   --GLLVYPEV KRLMFRIAMR ILLGCEPQLA G--------- --DGDSEQQL 
CYP26B1h   --AINVYQEA QKLTFRMAIR VLLGFSIPEE ---------- -----DLGHL 
CYP26C1h   --PVSVYDAS KALTFRMAAR ILLGLRLDEA ---------- -----QCATL 
CYP27A1h   V--SDMAQLF YYFALEAICY ILFEKRIGCL QRS---IPED TVTFVRSIG- 
CYP27B1h   V--RDVAGEF YKFGLEGIAA VLLGSRLGCL EAQ---VPPD TETFIRAVG- 
CYP27C1h   V--TNVNDLF FKYSMEGVAT ILYESRLGCL ENS---IPQL TVEYIEALEL 
CYP39A1h   --TMDLNNLV RHLLYPVTVN MLFNKSLFST ---------- --NKKKIKEF 
CYP46h     ---VSMQDML TYTAMDILAK AAFGMETSML LGA----QKP LSQAVKLMLE 
CYP51h     SGEKNVFEAL SELIILTASH CLHGKEIRS- --Q------- L-NEKVAQLY 

Cyp1a1     T-GS---GYP ADFIP----- VLRYLPNSS- ---------- -----LDAFK 
Cyp1a2     V-TS---GNA VDFFP----- VLRYLPNPA- ---------- -----LKRFK 
Cyp1b1     V-GA---GSL VDVLP----- WLQLFPNPVR TT-------- -----FRKFE 
Cyp2a4     T-AT-SMGQV YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
Cyp2a5     T-AT-SMGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
Cyp2a12    A-AS-PTGQL YDMFH----S VMKYLPGP-- ---------- -----QQQII 
Cyp2a22    A-AS-PTGQL YDMFH----S VMKYLPGP-- ---------- -----QQQII 
Cyp2b9     L-SS-FSGQM FELFS----G FLKYFPGV-- ---------- -----HRQIV 
Cyp2b10    I-SS-FSSQM FELFS----G FLKYFPGA-- ---------- -----HRQIS 
Cyp2b13    L-RS-FSCQM FELFS----G LLKYFPGV-- ---------- -----HRQIA 
Cyp2b19    M-SS-LSSQV FELFS----A ILKYFPGA-- ---------- -----HRQIS 
Cyp2b23    I-SS-FSSQL FELFS----A VMKYFPGT-- ---------- -----HRQIS 
Cyp2c29    L-SS-PWLQV CNSFPS---- LIDYCPGS-- ---------- -----HHKIV 
Cyp2c37    L-SS-PWLQI CNTYPA---- LLDYCPGS-- ---------- -----HKQFF 
Cyp2c38    L-SS-PWLQV CNNFPL---- LIDYCPGS-- ---------- -----HHKVL 
Cyp2c39    L-SS-PWLQV CNNFPL---- LIDYCPGS-- ---------- -----HHKVL 
Cyp2c40    L-SS-PGCQI FNAVPI---- LIDYCPGS-- ---------- -----HNKLF 
Cyp2c44    L-NS-IWIQM YNLWPT---- IMKYIPGK-- ---------- -----HREFS 
Cyp2c50    M-ST-PWLQV CNTFPV---- LLDYCPGS-- ---------- -----HNKVF 
Cyp2c54    L-ST-PWLQV CNTFPA---- LLDYCPGS-- ---------- -----HNQFF 
Cyp2c55    L-NS-PWMQV YNALPT---- LINYLPGS-- ---------- -----HNKVI 
Cyp2c65    L-SS-PWIQI CNNFPA---- VIDYLPGR-- ---------- -----HRKLH 
Cyp2c66    L-SS-PWIQV CNNFPA---- IIDYLPGR-- ---------- -----HRKLL 
Cyp2c67    L-SS-PGCQI FNAVPI---- LIDYCPGR-- ---------- -----HNKFF 
Cyp2c68    L-SS-PECQI FNAVPI---- LIDYCPGS-- ---------- -----HNKFL 
Cyp2c69    L-SS-PGCQI FNAVPI---- LIDYCPGR-- ---------- -----HNKFF 
Cyp2c70    L-AS-PWSQL CSAYP----- ILYYLPGI-- ---------- -----HNRFL 
Cyp2ac1    I-GN-PSIVL LNMFP----- ILGFLLRS-- ---------- -----KKKVL 
Cyp2ab1    A-ST-IWRRL YDMFP----- WALRHLSG-- ---------- -----PHQKI 
Cyp2d9     V-SG-LIPEV LNAFP----I LLRIP-RL-- ---------- -----ADKAL 
Cyp2d10    I-SL-AYSEV LNMFP----I LLRIP-GL-- ---------- -----PGKVF 
Cyp2d34    V-TG-FIPGV LNTFP----I LLRIP-GL-- ---------- -----ADMVF 
Cyp2d11    I-SG-FIPGV LNEFP----I FLRIP-GL-- ---------- -----ADMVF 
Cyp2d12    L-SG-LIPEV INTFP----I LLHIP-RL-- ---------- -----ADKFL 
Cyp2d13    N-TG-LFPEV LNTFP----I LLHIP-GL-- ---------- -----ADKVF 
Cyp2d40    K-IG-LIPEV VKMFP----I VLRIP-GL-- ---------- -----ADKIF 
Cyp2d22    E-AG-FLPMF LNVFP----M LLRIP-GL-- ---------- -----VGKVF 
Cyp2d26    D-TG-FVGEV LNAIP----M LLHIP-GL-- ---------- -----PDKAF 
Cyp2e1     L-ST-PWIQA YNYFS----D YLQYLPGS-- ---------- -----HRKVM 
Cyp2f2     M-SS-PWGEM YNIFP----S VLDWIPGP-- ---------- -----HKRLF 
Cyp2g1     M-SK-PWAQL YDMYW----K VMQYFPGR-- ---------- -----HNYLY 
Cyp2j5     M-GS-SAGQL YNGFP----C IMKYLPGP-- ---------- -----HQKIF 
Cyp2j6     E-TT-MISQL YNIFP----W IMKYIPGS-- ---------- -----HQKVF 
Cyp2j7     E-TS-MMLVL YNALP----S IMKYLPGP-- ---------- -----HQTVF 
Cyp2j8     E-AS-KVLML YNVFP----S IFKYLPGP-- ---------- -----HQKLF 
Cyp2j9     E-SS-MMCQL YNIFP----R ILQYLPGS-- ---------- -----HQTLF 
Cyp2j13    G-TTSLMVHL YNIFP----W ITKHLPGQ-- ---------- -----HQTLL 
Cyp2j12    E-AS-MMCQL YNVFP----S IIQYVPGS-- ---------- -----HQTVL 
cyp2j11    E-AS-MMSVL YNVFP----S IFKYLPGP-- ---------- -----QQKLF 
Cyp2r1     A-AS-APVFL YNAFP----W IGILPFGK-- ---------- -----HQRLF 
Cyp2s1     I-SS-PWGQA YEMFS----W LLQPLPGP-- ---------- -----HTQLQ 
Cyp2t4     M-SS-RWAEI YNMFP----S FMDWIPGP-- ---------- -----HNRIF 
Cyp2U1     C-LH-SQLFL INICP----W FYYLPFGP-- ---------- -----FKELR 
Cyp2w1     L-GS-PGIQL FNTFP----R LGAFLRL--- ---------- -----HRPVL 
CYP2W1h    L-GS-PGLQL FNVYP----W LGALLQL--- ---------- -----HRPVL 
Cyp3a11    KAKKLLRFDF FDPL----LF SVVLFP---- ---------- -------FLT 
Cyp3a13    KIKKLLKFDI FDPL----FL SVTLFP---- ---------- -------FLT 
Cyp3a16    NAKKVLRFDY FDPL----SL SVALFP---- ---------- -------FLT 
Cyp3a25    KAKKILKFKV FDPF----LL SIILFP---- ---------- -------FLT 
Cyp3a59    KTKKILKFKI FDPF----LL SVVLFP---- ---------- -------FLT 
Cyp3a57    KIKKILKFKF FDPF----LL SVVLFP---- ---------- -------FLT 
Cyp3a41    KAKGILRVDF FDPL----VF SVVLFP---- ---------- -------FLT 
Cyp3a44    EAKKFLRVDF FDPL----LF SVVLFP---- ---------- -------LLT 
Cyp4a10    FHSRVRNIFH QNDT----IY KLS------- ---------- ---SNGRLAK 
Cyp4a31    VHSRVRNMFH QNDT----IY KLS------- ---------- ---SNGRLSN 
Cyp4a32    FHSRVRNIFH QNDT----IY RLS------- ---------- ---SNGRLAK 
Cyp4a12a   VFSRVRNIFH QNDI----IY RVS------- ---------- ---SNGCKAN 
Cyp4a12b   FFLRVRNIFH QNDI----IY RVS------- ---------- ---SNGCLAN 
Cyp4a14    TFFRLRNAFY KYNI----IY NMS------- ---------- ---SDGRLSH 
Cyp4a30b   IYLRVRNGFH QNNT----IY SLSSFRA--M ES-------- HIFTNGRSFY 
Cyp4a29    VTSRMKNVFL HNDI----IY NLT------- ---------- ---SHSRRTN 
Cyp4b1     MQQRIDSFQY HNDF----IY WLTP------ ---------- ----HGRRFL 
Cyp4f13    VVKRHRQPFL YLDL----LY YLTA------ ---------- ----DGRRFR 
Cyp4f14    VAKRHQQPLM FMDL----LY NLTP------ ---------- ----DGMRFR 
Cyp4f15    VTKRYHQLLL HIDS----LY QLTC------ ---------- ----SGRRFH 
Cyp4f16    IIKRSLQLFL FVDF----LY YHTA------ ---------- ----DGRRFR 
Cyp4f17    IVKRHHQPFL YLDF----LY YCTA------ ---------- ----DGRRFR 
Cyp4f18    VARRHQRLLL HVDL----FY YLTH------ ---------- ----DGMRFR 
Cyp4f37    VIKRSHQLFL FVDF----LY YHTA------ ---------- ----DGRRFR 
Cyp4f39    VVRRQYRLHH YLDF----MY YLTA------ ---------- ----DGRRFR 
Cyp4f40    AVKRNEQLLM HVDL----LY RLTP------ ---------- ----DGMRFY 
Cyp4v3     IYRRMKMPWL WFDL----WY LVFK------ ---------- ----EGRDHK 
Cyp4x1     ISSRLYNFWH HHDI----IF KLS------- ---------- ---PKGHCFQ 
Cyp5a1     HCRRASTFCI PRPL----LV LILSFP---- ---------- -------SIM 
Cyp7a1     QNNLDSFKQF DQVFP----- ---------- ---------- -----ALVAG 
Cyp7b1     SELRDDFFKF DDMFP----- ---------- ---------- -----YLVSD 
Cyp8a1     ADVFHTFRQL DLLLP----- ---------- ---------- -----KLARG 
Cyp8b1     DELFRKFRRF DFLFP----- ---------- ---------- -----RFVYS 
Cyp11a1    --QMFHTSVP MLNLP---PD FFRLLRTK-- ---------- ----TWKDHA 
Cyp11b1    --SMFKTTTQ LLYLP---RS LTRWTSTR-- ---------- ----VWKENL 
Cyp11b2    --SMFKSTSQ LLFLP---KS LTRWTSTR-- ---------- ----VWKEHF 
Cyp17      L-GHS---DL VDIFP----- WLKIFPNKN- ---------- -----LEMIK 
Cyp19      LLIK---PNI FFKIS----W LYRKYERS-- ---------- -----VKDLK 
Cyp20      WSEIGKGFLD GSLD----KN TTR------- ---------- ----K-KQYQ 
Cyp21      W-NHWS-IQI LTIIP----- LLRFLPNPG- ---------- -----LQKLK 
Cyp24      --TMMSTFGK MMVTP---VE LHKRLNTK-- ---------- ----VWQAHT 
Cyp26a1    VEAFEEMTRN LFSLPI---- ---------- ---------- -----DVPFS 
Cyp26b1    FEVYQQFVEN VFSLPV---- ---------- ---------- -----DLPFS 
Cyp26c1    AHTFEQLVEN LFSLPL---- ---------- ---------- -----DVPFS 
Cyp27a1    --IMFQNSVY ITFLP---KW TRPLLP---- ---------- ----FWKRYL 
Cyp27b1    --SVFVSTLL TMAMP---NW LHHLIPG--- ---------- ----PWARLC 
Cyp39      YQQFKTYDEG FEYGS----- ---------- ---------- -----QLPEW 
Cyp46      GISASRNTLA KFMP----GK RKQ------- ---------- ----L-REIR 
Cyp51      ADLDGGFTHA AWLLPA---- ---------- ---------- -----WLPLP 
CYP1A1h    V-GS---GNP ADFIP----- ILRYLPNPS- ---------- -----LNAFK 
CYP1A2h    A-SS---GNP LDFFP----- ILRYLPNPA- ---------- -----LQRFK 
CYP1B1h    V-GA---GSL VDVMP----- WLQYFPNPVR TV-------- -----FREFE 
CYP2A6     T-ST-STGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
CYP2A7     T-ST-STGQL YEMFS----S LMKHLPGP-- ---------- -----QQQAF 
CYP2A13    T-GT-STGQL YEMFS----S VMKHLPGP-- ---------- -----QQQAF 
CYP2B6     I-SS-VFGQL FELFS----G FLKYFPGA-- ---------- -----HRQVY 
CYP2C8     L-NS-PWIQV CNNFPL---- LIDCFPGT-- ---------- -----HNKVL 
CYP2C9     L-SS-PWIQI CNNFSP---- IIDYFPGT-- ---------- -----HNKLL 
CYP2C18    L-SS-PWIQV CNNFPA---- LIDYLPGS-- ---------- -----HNKIA 
CYP2C19    V-ST-PWIQI CNNFPT---- IIDYFPGT-- ---------- -----HNKLL 
CYP2D6     E-SG-FLREV LNAVP----V LLHIP-AL-- ---------- -----AGKVL 
CYP2E1h    L-ST-PWLQL YNNFPS---- FLHYLPGS-- ---------- -----HRKVI 
CYP2F1     M-SS-PWGEL YDILDPRFPS LLDWVPGP-- ---------- -----HQRIF 
CYP2G2P    M-ST-PWAQL YDMYS----G IMQYLPGR-- ---------- -----HNLIY 
CYP2J2     E-AS-KTCQL YNVFP----W IMKFLPGP-- ---------- -----HQTLF 
CYP2R1h    A-AS-ASVFL YNAFP----W IGILPFGK-- ---------- -----HQQLF 
CYP2S1h    V-SS-QGGQT YEMFS----W FLRPLPGP-- ---------- -----HKQLL 
CYP2T2P    I-SS-RWGES ---------- LMDWLPGP-- ---------- -----HHRIF 
CYP2U1h    C-LN-SQVLL VNICP----W LYYLPFGP-- ---------- -----FKELR 
CYP3A4     NTKKLLRFDF LDPF----FL SIIFP----- ---------- -------FLI 
CYP3A5     STKKFLKFGF LDPL----FL SIILFP---- ---------- -------FLT 
CYP3A7     NTKKLLRFNP LDPF----VL SIKVFP---- ---------- -------FLT 
CYP3A43    NMKKLLKLDF LDPF----LL LISLFP---- ---------- -------FLT 
CYP4A11    VFSRVRNAFH QNDT----IY SLT------- ---------- ---SAGRWTH 
CYP4A22    VFCCMRNAFH ENDT----IY SLT------- ---------- ---SAGRWTH 
CYP4B1h    MQQRLVSFQY HNDF----IY WLTP------ ---------- ----HGRRFL 
CYP4F2     VSKRHHEILL HIDF----LY YLTP------ ---------- ----DGQRFR 
CYP4F3     VTKRHQQILL YIDF----LY YLTP------ ---------- ----DGQRFR 
CYP4F8     VVKRNNQFFR YKDF----LY FLTP------ ---------- ----CGRRFH 
CYP4F11    VEKRNQQILL HTDF----LY YLTP------ ---------- ----DGQRFR 
CYP4F12    VEKRSQHILQ HMDF----LY YLSH------ ---------- ----DGRRFH 
CYP4F22    SVRRQYRLHH YLDF----IY YRSA------ ---------- ----DGRRFR 
CYP4F23P   SLKRHQHIFL LTDF----LY FLTP------ ---------- ----NGRRFC 
CYP4V2     IFRRIKMPWL WLDL----WY LMFK------ ---------- ----EGWEHK 
CYP4X1h    IFHRLYSLLY HSDI----IF KLS------- ---------- ---PQGYRFQ 
CYP4Z1     SNQRMNNFLH HNDL----VF KFS------- ---------- ---SQGQIFS 
CYP5A1h    HCKRFFEFCI PRPI----LV LLLSFP---- ---------- -------SIM 
CYP7A1h    LNNLDNFKQF DKVFP----- ---------- ---------- -----ALVAG 
CYP7B1h    SELRDDFLKF DDKFA----- ---------- ---------- -----YLVSN 
CYP8A1h    ADVFHTFRQL DRLLP----- ---------- ---------- -----KLARG 
CYP8B1h    GELFMEFRKF DLLFP----- ---------- ---------- -----RFVYS 
CYP11A1h   --QMFHTSVP MLNLP---PD LFRLFRTK-- ---------- ----TWKDHV 
CYP11B1h   --VMFKSTVQ LMFMP---RS LSRWTSPK-- ---------- ----VWKEHF 
CYP11B2h   --VMFKSTVQ LMFMP---RS LSRWISPK-- ---------- ----VWKEHF 
CYP17h     L-SKD---SL VDLVP----- WLKIFPNKT- ---------- -----LEKLK 
CYP19h     LLIK---PDI FFKIS----W LYKKYEKS-- ---------- -----VKDLK 
CYP20h     WSEIGKGFLD GSLD----KN MTR------- ---------- ----K-KQYE 
CYP21A2h   W-SHWS-IQI VDVIP----- FLRFFPNPG- ---------- -----LRRLK 
CYP24h     --TMMSTFGR MMVTP---VE LHKSLNTK-- ---------- ----VWQGHT 
CYP26A1h   VEAFEEMTRN LFSLPI---- ---------- ---------- -----DVPFS 
CYP26B1h   FEVYQQFVDN VFSLPV---- ---------- ---------- -----DLPFS 
CYP26C1h   ARTFEQLVEN LFSLPL---- ---------- ---------- -----DVPFS 
CYP27A1h   --LMFQNSLY ATFLP---KW TRPVLP---- ---------- ----FWKRYL 
CYP27B1h   --SVFVSTLL TMAMP---HW LRHLVPG--- ---------- ----PWGRLC 
CYP27C1h   MFSMFKTSMY AGAIP---RW LRPFIPK--- ---------- ----PWREFC 
CYP39A1h   HQYFQVYDED FEYGS----- ---------- ---------- -----QLPEC 
CYP46h     GITASRNTLA KFLP----GK RKQ------- ---------- ----L-REVR 
CYP51h     ADLDGGFSHA AWLLPG---- ---------- ---------- -----WLPLP 

Cyp1a1     DLNDKFYSFM K--KLIKEHY RTFEK-GH-- ---------- --IRDITDSL 
Cyp1a2     TFNDNFVLFL Q--KTVQEHY QDFNK-NS-- ---------- --IQDITSAL 
Cyp1b1     QLNRNFSNFV L--DKFLRHR ESLVPGAA-- ---------- --PRDMTDAF 
Cyp2a4     KELQGLEDFI T--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
Cyp2a5     KELQGLEDFI T--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
Cyp2a12    KDSHKLEDFM I--QKVKQNQ STLDPN-S-- ---------- --PRDFIDSF 
Cyp2a22    KDSHKLEDFM I--QKVKHNH STLDPN-S-- ---------- --PRGFIDSF 
Cyp2b9     KKQQELLDYI A--HSVEKHK ATLDPS-A-- ---------- --PRDYIDTY 
Cyp2b10    KNLQELLDYI G--HSVEKHR ATLDPS-V-- ---------- --PRDFIDIY 
Cyp2b13    KNQQEILNFI T--HRVEKHR ASLDPS-E-- ---------- --PRDFIDTY 
Cyp2b19    KNLQEILDYI G--HSVEKHR ATLDPS-A-- ---------- --PRDFIDTY 
Cyp2b23    KNIQEILNYI G--HSVEQHK ATLDPS-A-- ---------- --PRDFIDTY 
Cyp2c29    KNFNYLKSYL L--EKIKEHK ESLDVT-N-- ---------- --PRDFIDYY 
Cyp2c37    KNYACIKNFL L--EKIKEHE ESLDVT-I-- ---------- --PRDFIDYF 
Cyp2c38    KNFKYIRSYL L--EKVKEHQ ASLDFT-N-- ---------- --PRDFIDYF 
Cyp2c39    KNVKYIRSYL L--EKIKEHQ ESLDVT-N-- ---------- --PRDFIDYY 
Cyp2c40    KNHTWIKSYL L--GKIKEHE ESLDVT-N-- ---------- --PRDFIDYF 
Cyp2c44    KRLGGVKNFI L--EKVKEHQ EFLDPA-N-- ---------- --PRDYIDCF 
Cyp2c50    KNYACIKNFL L--EKIKEHE ESLDVT-I-- ---------- --PRDFIDYF 
Cyp2c54    KNYAYIKNFL L--EKIREHK ESLDVT-I-- ---------- --PRDFIDYF 
Cyp2c55    KNFTEIKSYI L--GRVKEHQ ETLDMD-N-- ---------- --PRDFIDCF 
Cyp2c65    KNFAFAEHYF L--SKVKQHQ ESLDIN-N-- ---------- --PRDFIDCF 
Cyp2c66    KNFDFAKHYF L--AKVIQHK ESLDIN-N-- ---------- --PRDFIDCF 
Cyp2c67    KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFIDYF 
Cyp2c68    KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFVDYF 
Cyp2c69    KNHTWIKSYL L--EKIKEHE ESLDVT-N-- ---------- --PRDFIDYF 
Cyp2c70    KDVTQQKKFI L--EEINRHQ KSLDLS-N-- ---------- --PQDFIDYF 
Cyp2ac1    RNRVELFSFI R--MAFLEHC HNRNKS-D-- ---------- --PRSLIDAF 
Cyp2ab1    FQYHEAVRGF I--RHEIIRH KLRTAE-A-- ---------- --PKDFINCY 
Cyp2d9     QGQKSFIAIL D--NLLTENR TTWDPVQA-- ---------- --PRNLTDAF 
Cyp2d10    QGQKSLLAIV E--NLLTENR NTWDPDQP-- ---------- --PRNLTDAF 
Cyp2d34    QSQKTFMAIL D--NLVTENR TTWDPDQP-- ---------- --PRNLADAF 
Cyp2d11    QGQKSFMAIL D--NLLTENR TTWDPDQP-- ---------- --PRNLTDAF 
Cyp2d12    QSQKSFIAIV D--NLLTENR TTWDPAQS-- ---------- --PRNLTDAF 
Cyp2d13    PGQKTFLTLV N--KLVTEHK RTWDPDQP-- ---------- --PRDLTDAF 
Cyp2d40    PGQKTFLTMV D--KLVTEHK RTWDPDQP-- ---------- --PRDLTDAF 
Cyp2d22    PGKRAFVTML D--ELLAEHK TTWDPTQP-- ---------- --PRDLTDAF 
Cyp2d26    PKLNSFIALV N--KMLIEHD LTWDPAQP-- ---------- --PRDLTDAF 
Cyp2e1     KNVSEIRQYT L--GKAKEHL KSLDIN-C-- ---------- --PRDVTDCL 
Cyp2f2     RNFGGMKDLI A--RSVREHQ DSLDPN-S-- ---------- --PRDFIDCF 
Cyp2g1     NLIEDLKDFI A--SRVKINE ASFDPS-N-- ---------- --PRDFIDCF 
Cyp2j5     RNWGKLKLFV S--HIVKKHE KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j6     RNWEKLKLFV S--CMIDDHR KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j7     RNWERLKMIV Y--HMMESHR KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j8     SNWEKLKLFF S---VMDSHR KDWNPSA--- ---------- --PRDFIDAF 
Cyp2j9     RNWRKLQLFV S--DIVNNHR RDWDPDE--- ---------- --PRDFIDAF 
Cyp2j13    ATWRKLKSYI A--DIIDNHR KDWNPDE--- ---------- --PRDFIDAF 
Cyp2j12    RNWEKLKLFI Y--QMMESHR KDWNPDE--- ---------- --PRDFIDAF 
cyp2j11    SNWEKLKLFV S--RMMDSHR EDWNPSA--- ---------- --PRDFIDAF 
Cyp2r1     RNADVVYDFL S--RLIEKAA VNRKPHL--- ---------- --PHHFVDAY 
Cyp2s1     HHLGTLAAFT I--QQVQKHQ GRFQTSGP-- ---------- --ARDVVDAF 
Cyp2t4     KNFQELRLFI S--EQIQWHW QSRQTG-E-- ---------- --PRDFIDCF 
Cyp2U1     QIERDISCFL K--NIIREHQ ESLDASN--- ---------- --PQDFIDMY 
Cyp2w1     SKIEEVRTIL R--TLLETRR PPLPTGGP-- ---------- --AQSYVEAL 
CYP2W1h    RKIEEVRAIL R--TLLEARR PHVCPGDP-- ---------- --VCSYVDAL 
Cyp3a11    PVYEMLNICM FPKDSIEFFK KFVDRMKESR -LDSKQKH-- --RVDFLQLM 
Cyp3a13    PVFDALNVSL FPRDVISFFT TSVERMKENR -MKEKEKQ-- --RVDFLQLM 
Cyp3a16    PIYEMLNICM FPKDSIEFFK KFVDRMTENR -LDSKQKH-- --RVDFIYLM 
Cyp3a25    PIYEMLNFSI FPRDSMNFFK KFVKRMKKER -LASNQKN-- --RVDFLQLM 
Cyp3a59    PIYEMLNLSI FPRDSMNFFK KFVKRMKKER -LASKQKN-- --RVDFLQLM 
Cyp3a57    PIYEMLNLSI FPRQSMNFFK KFVKKMKKDR -LDYNQKN-- --RVDFLQLM 
Cyp3a41    PVYEMLNICM FPKDSIEFFK KFVNRMKESR -LDSKQKH-- --RVDFLQLM 
Cyp3a44    PVYEMLNICM FPNDSIEFFK KFVDRMQESR -LDSNQKH-- --RVDFLQLM 
Cyp4a10    QACQLAHDHT --DGVIKLRK DQLQDEGELE KIKKKRR--- ---LDFLDIL 
Cyp4a31    QACQLAHDHT --DGVIKMRK DQLQDEGELE NIKKKRR--- ---LDFLDIL 
Cyp4a32    QACQLAHDHT --DGVIKMRK DQLQDEGELE NIKKKRR--- ---LDFLDIL 
Cyp4a12a   SACKLAHDHT --DQVIKSRR IQLQDEEELE KLKKKRR--- ---LDFLDIL 
Cyp4a12b   SACQLAHDHT --DQVIKSRR SQLQDEEELE KLKKKRR--- ---LDFLDIL 
Cyp4a14    HACQIAHEHT --DGVIKMRK SQLQNEEELQ KARKKRH--- ---LDFLDIL 
Cyp4a30b   HACQIAHKHT --ERVIRMRK AQLQNEAELE KFRKKKR--- ---LDFLDIL 
Cyp4a29    SACQIAHEHT --DRVVKLRK AQLQDNKSMK KLRGKRC--- ---LDFLDIL 
Cyp4b1     RACQIAHDHT --DHVIRQRK AALQDEKEQK KLQERRH--- ---LDFLDIL 
Cyp4f13    KACDLVHNFT --DAVIKERR STLN-TQGVE FLKAKAKT-- -KTLDFIDVL 
Cyp4f14    KACNVVHEFT --DAVIRERH RTLPDQGLDD FLKSKAKS-- -KTLDFIDVL 
Cyp4f15    KACHLVHSFT --DAVIQDRR RTLPSKHEDD VLKAKAKS-- -KTLDFIDVL 
Cyp4f16    KACDLVHNFT --DAVIRERR HTLSSQNHDE FLKSKTKS-- -KTLDFIDVL 
Cyp4f17    KACDLVHNFT --DAVIRERR RTLSSQNLDE FLKSKTKS-- -KTLDFIDVL 
Cyp4f18    KACRLVHDFT --DAVIRERR RTLLDQGGDD VLKAKAKA-- -KTLDFIDVL 
Cyp4f37    KACDLVHNFT --DAVIRERR HTLSSQNHDE FLKSKTKS-- -KTLDFIDVL 
Cyp4f39    QACDTVHNFT --TEVIQERR QALRQQGAEA WLKAKQG--- -KTLDFIDVL 
Cyp4f40    KACRLVHDFT --DAVIQERR RTLLKHGGDD IIKAKAKS-- -KTLDFIDVL 
Cyp4v3     RGLKCLHTFT --NNVIAERV KERKAEEDWT GAGRGPIPSK NKRKAFLDLL 
Cyp4x1     ELGKVIHQYT --EKIIQDRK KILKNQVKQD DTQTS----- ---QIFLDIV 
Cyp5a1     VPLARILPNK NRDELNGFFN TLIRNVIALR DQQAAEER-- --RRDFLQMV 
Cyp7a1     VPIHLLKTAH KARERLAESL KHKNLYMRDQ V--------- ----SELIRL 
Cyp7b1     IPIQLLRNEE SMQKKIIKCL TSEKVAQMQG Q--------- ----SKIVQE 
Cyp8a1     SLSAGDKDHA CSVKNRLWKL LSPARLASRA D--------- ----RSSWLE 
Cyp8b1     LLGPREWVEV SQLQRLFHQR LSVEQNLEKD G--------- ----ISCWLG 
Cyp11a1    AAWDVIFNKA D--EYTQNFY WDLRQK-R-- ---------- --DFSQYPGV 
Cyp11b1    ESWDFISEYG T--KCIKNVY RELAEG---- ---------- --RPQSWS-V 
Cyp11b2    DAWDVISEYG N--RCIWKVH QELRLG---- ---------- --SSQTYSGI 
Cyp17      EHTKIREKTL V--EMFEKCK EKFNSE-S-- ---------- --LSSLTDIL 
Cyp19      DEIAVLVEKK R--HKVSTAE KLEDC----- ---------- ---MDFATDL 
Cyp20      EALMQLESTL --KKIIKERK GGNFR----- ---------- -----QHTFI 
Cyp21      QIQESRDHIV K--QQLKRHK DSLVAG-Q-- ---------- --WKDMIDYM 
Cyp24      LAWDTIFKSV K--PCIDHRL ERYSQQPG-- ---------- -------ADF 
Cyp26a1    GLYRGVKARN LIHARIEENI RAKIRRLQAT EPDGGCK--- ----DALQLL 
Cyp26b1    GYRRGIQARQ ILQKGLEKAI REKLQCTQGK DYS------- ----DALDIL 
Cyp26c1    GLRKGIRARD QLYEHLDEAV AEKLQEKQTA EPG------- ----DALLLI 
Cyp27a1    NGWDNIFSFG K--KLIDEKV QELKAQLQET ---------- GPDGVRVSGY 
Cyp27b1    RDWDQMFAFA Q--RHVELRE GEAAMRNQGK ---------- PEEDMPSGHH 
Cyp39      LLRNWSKSKR WLLALFEKNI GNIKAHGSAG ---------- ----HSGTLL 
Cyp46      ESIRLLRQVG --KDWVQRRR EALKRGED-- ---MPA---- ----DILTQI 
Cyp51      SFRRRDRAHR EIKNIFYKAI QKRRLSKEPA E--------- ----DILQTL 
CYP1A1h    DLNEKFYSFM Q--KMVKEHY KTFEK-GH-- ---------- --IRDITDSL 
CYP1A2h    AFNQRFLWFL Q--KTVQEHY QDFDK-NS-- ---------- --VRDITGAL 
CYP1B1h    QLNRNFSNFI L--DKFLRHC ESLRPGAA-- ---------- --PRDMMDAF 
CYP2A6     QLLQGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
CYP2A7     KLLLGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PQDFIDSF 
CYP2A13    KELQGLEDFI A--KKVEHNQ RTLDPN-S-- ---------- --PRDFIDSF 
CYP2B6     KNLQEINAYI G--HSVEKHR ETLDPS-A-- ---------- --PKDLIDTY 
CYP2C8     KNVALTRSYI R--EKVKEHQ ASLDVN-N-- ---------- --PRDFMDCF 
CYP2C9     KNVAFMKSYI L--EKVKEHQ ESMDMN-N-- ---------- --PQDFIDCF 
CYP2C18    ENFAYIKSYV L--ERIKEHQ ESLDMN-S-- ---------- --ARDFIDCF 
CYP2C19    KNLAFMESDI L--EKVKEHQ ESMDIN-N-- ---------- --PRDFIDCF 
CYP2D6     RFQKAFLTQL D--ELLTEHR MTWDPAQP-- ---------- --PRDLTEAF 
CYP2E1h    KNVAEVKEYV S--ERVKEHH QSLDPN-C-- ---------- --PRDLTDCL 
CYP2F1     QNFKCLRDLI A--HSVHDHQ ASS------- ---------- --PRDFIQCF 
CYP2G2P    YLVEELKDFI A--SRVKINE ASFDPQ-N-- ---------- --PRDFIDCF 
CYP2J2     SNWKKLKLFV S--HMIDKHR KDWNPAE--- ---------- --TRDFIDAY 
CYP2R1h    RNAAVVYDFL S--RLIEKAS VNRKPQL--- ---------- --PQHFVDAY 
CYP2S1h    HHVSTLAAFT V--RQVQQHQ GNLDASGP-- ---------- --ARDLVDAF 
CYP2T2P    RNFSELRVIS ---EQIQRHW QMRQPA-E-- ---------- --PRDFIDCL 
CYP2U1h    QIEKDITSFL K--KIIKDHQ ESLDREN--- ---------- --PQDFIDMY 
CYP3A4     PILEVLNICV FPREVTNFLR KSVKRMKESR -LEDTQKH-- --RVDFLQLM 
CYP3A5     PVFEALNVSL FPKDTINFLS KSVNRMKKSR -LNDKQKH-- --RLDFLQLM 
CYP3A7     PILEALNITV FPRKVISFLT KSVKQIKEGR -LKETQKH-- --RVDFLQLM 
CYP3A43    PVFEALNIGL FPKDVTHFLK NSIERMKESR -LKDKQKH-- --RVDFFQQM 
CYP4A11    RACQLAHQHT --DQVIQLRK AQLQKEGELE KIKRKRH--- ---LDFLDIL 
CYP4A22    RACQLAHQHT --DQVIQLRK AQLQKEGELE KIKRKRH--- ---LDFLDIL 
CYP4B1h    RACQVAHDHT --DQVIRERK AALQDEKVRK KIQNRRH--- ---LDFLDIL 
CYP4F2     RACRLVHDFT --DAVIQERR RTLPSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4F3     RACRLVHDFT --DDVIQERR RTLPSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4F8     RACRLVHDFT --DAVIQERR RTLTSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4F11    RACHLVHDFT --DAVIQERR RTLPTQGIDD FLKNKAKS-- -KTLDFIDVL 
CYP4F12    RACRLVHDFT --DAVIRERR RTLPTQGIDD FFKDKAKS-- -KTLDFIDVL 
CYP4F22    QACDMVHHFT --TEVIQERR RALRQQGAEA WLKAKQG--- -KTLDFIDVL 
CYP4F23P   RACDIVHNFT --DAVIQERR RTLTSQGVDD FLQAKAKS-- -KTLDFIDVL 
CYP4V2     KSLQILHTFT --NSVIAERA NEMNANEDCR GDGRGSAPSK NKRRAFLDLL 
CYP4X1h    KLSRVLNQYT --DTIIQERK KSLQAGVKQD NTPKRKY--- ---QDFLDIV 
CYP4Z1     KFNQELHQFT HLEKVIQDRK ESLKDKLKQD TTQKRR---- ---WDFLDIL 
CYP5A1h    VPLARILPNK NRDELNGFFN KLIRNVIALR DQQAAEER-- --RRDFLQMV 
CYP7A1h    LPIHMFRTAH NAREKLAESL RHENLQKRES I--------- ----SELISL 
CYP7B1h    IPIELLGNVK SIREKIIKCF SSEKLAKMQG W--------- ----SEVFQS 
CYP8A1h    SLSVGDKDHM CSVKSRLWKL LSPARLARRA H--------- ----RSKWLE 
CYP8B1h    LLWPREWLEV GRLQHLFHKM LSVSHSQEKE G--------- ----ISNWLG 
CYP11A1h   AAWDVIFSKA D--IYTQNFY WELRQKGS-- ---------- --VHHDYRGM 
CYP11B1h   EAWDCIFQYG D--NCIQKIY QELAFS---- ---------- --RPQQYTSI 
CYP11B2h   EAWDCIFQYG D--NCIQKIY QELAFN---- ---------- --RPQHYTGI 
CYP17h     SHVKIRNDLL N--KILENYK EKFRSD-S-- ---------- --ITNMLDTL 
CYP19h     DAIEVLIAEK R--CRISTEE KLEEC----- ---------- ---MDFATEL 
CYP20h     DALMQLESVL --RNIIKERK GRNFS----- ---------- -----QHIFI 
CYP21A2h   QAIEKRDHIV E--MQLRQHK ESLVAG-Q-- ---------- --WRDMMDYM 
CYP24h     LAWDTIFKSV K--ACIDNRL EKYSQQPS-- ---------- -------ADF 
CYP26A1h   GLYRGMKARN LIHARIEQNI RAKICGLRAS EAGQGCK--- ----DALQLL 
CYP26B1h   GYRRGIQARQ ILQKGLEKAI REKLQCTQGK DYL------- ----DALDLL 
CYP26C1h   GLRKGIRARD QLHRHLEGAI SEKLHEDKAA EPG------- ----DALDLI 
CYP27A1h   DGWNAIFSFG K--KLIDEKL EDMEAQLQAA ---------- GPDGIQVSGY 
CYP27B1h   RDWDQMFAFA Q--RHVERRE AEAAMRNGGQ ---------- PEKDLESGAH 
CYP27C1h   RSWDGLFKFS Q--IHVDNKL RDIQYQMD-- ---------- RGR-RVSGGL 
CYP39A1h   LLRNWSKSKK WFLELFEKNI PDIKACKSAK D--------- ----NSMTLL 
CYP46h     ESIRFLRQVG --RDWVQRRR EALKRGEE-- ---VPA---- ----DILTQI 
CYP51h     SFRRRDRAHR EIKDIFYKAI QKRRQSQEKI D--------- ----DILQTL 

Cyp1a1     IEHCQDRKL- ---------- ---------- ------DENA NVQLSDDKVI 
Cyp1a2     FKHSEN---- ---------- ---------- ------YKDN GGLIPEEKIV 
Cyp1b1     ILSAEKKASG ---------- ---------- -----APGDD SSGLDLEDVP 
Cyp2a4     LIRMLEEK-- ---------- ---------- ------KNPN TE-FYMKNLV 
Cyp2a5     LIRMLEEK-- ---------- ---------- ------KNPN TE-FYMKNLV 
Cyp2a12    LIHMQKE--- ---------- ---------- ------KYVN SE-FHMKNLV 
Cyp2a22    LIHMQKE--- ---------- ---------- ------KNFN SE-FHMKNLV 
Cyp2b9     LLRMEKEK-- ---------- ---------- ------SNHN TE-FHHQNLM 
Cyp2b10    LLRMEKEK-- ---------- ---------- ------SNQH TE-FHHQNLM 
Cyp2b13    LLRMEKEK-- ---------- ---------- ------SNHN TE-FHHQNLM 
Cyp2b19    LLRMEKEK-- ---------- ---------- ------SNHH TE-FHHQNLV 
Cyp2b23    LLRMEKEK-- ---------- ---------- ------SNHH TE-FHHQNLL 
Cyp2c29    LIKQKQVN-- ---------- ---------- ------HIEQ SE-FSLENLA 
Cyp2c37    LINGGQED-- ---------- ---------- ------GNQP LQ-NRLEHLA 
Cyp2c38    LIKQKQAN-- ---------- ---------- ------HIEQ AE-YSLENLV 
Cyp2c39    LIKQKQAN-- ---------- ---------- ------HIQQ AE-FSLENLA 
Cyp2c40    LIQRRQKN-- ---------- ---------- ------GIEH MD-YTIEHLA 
Cyp2c44    LSKIEEEK-- ---------- ---------- ------HSLK SD-FNLENLA 
Cyp2c50    LINGGQED-- ---------- ---------- ------GNYP LK-NRLEHLA 
Cyp2c54    LIKGAQED-- ---------- ---------- ------DNHP LK-NNFEHLA 
Cyp2c55    LIKMEQEK-- ---------- ---------- ------HNPH SE-FTIESLM 
Cyp2c65    LIKMEQEK-- ---------- ---------- ------HNPK TE-FTCENLV 
Cyp2c66    LIKMEQEK-- ---------- ---------- ------HNPK TE-FTCENLI 
Cyp2c67    LIQRCQKK-- ---------- ---------- ------GIEH ME-YTIEHLA 
Cyp2c68    LIQRRQKN-- ---------- ---------- ------GIEH MD-YTIEHLA 
Cyp2c69    LIQRRQKN-- ---------- ---------- ------GIEH ME-YTIEHLA 
Cyp2c70    LIKMEKEK-- ---------- ---------- ------HNQK SE-FTMDNLV 
Cyp2ac1    LVRQQGEN-- ---------- ---------- ------NTSA NH-FNEENLL 
Cyp2ab1    LSQITKAI-- ---------- ---------- ------DDPV ST-FSEENLI 
Cyp2d9     LAQIEKAK-- ---------- ---------- ------GNPE SS-FNDENLL 
Cyp2d10    LAEIEKVK-- ---------- ---------- ------GNAE SS-FNDENLR 
Cyp2d34    LAEIQKAK-- ---------- ---------- ------GNPE SS-FNDENLC 
Cyp2d11    LAEIEKAK-- ---------- ---------- ------GNAE SS-FNDENLR 
Cyp2d12    LAEIEKAK-- ---------- ---------- ------GNPE SS-FNDENLR 
Cyp2d13    LAEMEKAK-- ---------- ---------- ------GNPK SS-FNEANLR 
Cyp2d40    MAEMETAK-- ---------- ---------- ------GNPE SS-FNEANLR 
Cyp2d22    LAEVEKAK-- ---------- ---------- ------GNPE SS-FNDENLR 
Cyp2d26    LAEVEKAK-- ---------- ---------- ------GNPE SS-FNDKNLR 
Cyp2e1     LIEMEKEK-- ---------- ---------- ------HSQE PM-YTMENIS 
Cyp2f2     LTKMAQEK-- ---------- ---------- ------QDPL SH-FNMDTLL 
Cyp2g1     LIKMHQDK-- ---------- ---------- ------SDPH TE-FNLKNLV 
Cyp2j5     LIEMQKDP-- ---------- ---------- ------DRTT S--FNEENLI 
Cyp2j6     LKEMTKYP-- ---------- ---------- ------EKTT S--FNEENLI 
Cyp2j7     LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2j8     LTEMAKYS-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2j9     LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2j13    LNEMAKYP-- ---------- ---------- ------GKTT TS-FNEENLI 
Cyp2j12    LTEMSKYG-- ---------- ---------- ------DKTT TS-FNEENLI 
cyp2j11    LTEMTKYP-- ---------- ---------- ------DKTT TS-FNEENLI 
Cyp2r1     LDEMDQGQ-- ---------- ---------- ------NDPL ST-FSKENLI 
Cyp2s1     LLKMAQEK-- ---------- ---------- ------QDPG TE-FTEKNLL 
Cyp2t4     LDQMDKEQ-- ---------- ---------- ------QDLE SH-FQDETLV 
Cyp2U1     LLHMEEEQ-- ---------- ---------- ------GASR RSSFDEDYLF 
Cyp2w1     LQQGQEDD-- ---------- ---------- --------PE DM-FGEANVL 
CYP2W1h    IQQGQGDD-- ---------- ---------- --------PE GL-FAEANAV 
Cyp3a11    MNSHNNS--- ---------- ---------- -----KDKVS HKALSDMEIT 
Cyp3a13    INSQN-Y--- ---------- ---------- -----KTKES HKALSDVEIV 
Cyp3a16    MEAYNKS--- ---------- ---------- -----KDKDS HKALSEIEIT 
Cyp3a25    MNTQN-S--- ---------- ---------- -----KGQES QKALSDLEMA 
Cyp3a59    MNTQN-S--- ---------- ---------- -----KGQES QKALSDLEMA 
Cyp3a57    MNTQN-S--- ---------- ---------- -----KGQES LKALSDLEMA 
Cyp3a41    MNAHNNS--- ---------- ---------- -----KDKDS HKALSDMEIT 
Cyp3a44    MNSHNNS--- ---------- ---------- -----KDKDS HKAFSNMEIT 
Cyp4a10    LFARME---- ---------- ---------- ---------N GDSMSDKDLR 
Cyp4a31    LFARME---- ---------- ---------- ---------N EDSMSDKDLR 
Cyp4a32    LFARME---- ---------- ---------- ---------N GDSMSDKDLR 
Cyp4a12a   LFARME---- ---------- ---------- ---------N GKSLSDKDLR 
Cyp4a12b   LFARME---- ---------- ---------- ---------N GKSLSDKDLR 
Cyp4a14    LFARME---- ---------- ---------- ---------D RNSLSDEDLR 
Cyp4a30b   LFAQTE---- ---------- ---------- ---------D GKSLSDEDVR 
Cyp4a29    LLSRVSS--- ---------- ---------- --------DD GSSLSDKALR 
Cyp4b1     LGARDE---- ---------- ---------- ---------S GIKLSDADLR 
Cyp4f13    LMAEDE---- ---------- ---------- ---------H GKGLSNEDIR 
Cyp4f14    LLSKDE---- ---------- ---------- ---------D GKELSDEDIR 
Cyp4f15    LLSKDE---- ---------- ---------- ---------D GKELSDEDIR 
Cyp4f16    LLAKDE---- ---------- ---------- ---------H GKELSDEDIR 
Cyp4f17    LLAKDE---- ---------- ---------- ---------H GKELSDEDIR 
Cyp4f18    LLSKDE---- ---------- ---------- ---------H GKALSDEDIR 
Cyp4f37    LLAKDE---- ---------- ---------- ---------H GKELSDEDIR 
Cyp4f39    LLAKDE---- ---------- ---------- ---------E GKELSDEDIR 
Cyp4f40    LLTKDE---- ---------- ---------- ---------D GKELSDEDIR 
Cyp4v3     LSVTDE---- ---------- ---------- ---------E GNRLSQEDIR 
Cyp4x1     LSAQGK---- ---------- ---------- --------ED ERAFSDADLR 
Cyp5a1     LDAQHSMNSV GVEGFDMVPE SLSSSECTKE PPQRCHPTST SKPFTVDEIV 
Cyp7a1     RMFLND---- ---------- ---------- ---------T LSTFDDMEKA 
Cyp7b1     SQDLLK---- ---------- ---------- ---------R YYRHDDSEIG 
Cyp8a1     SYLRHL---- ---------- ---------- ---------E EMGVSEEMQA 
Cyp8b1     YMLQFL---- ---------- ---------- ---------R EQGIASSMQD 
Cyp11a1    LYSLLGGNK- ---------- ---------- ---------- ---LPFKNIQ 
Cyp11b1    TAELVAERT- ---------- ---------- ---------- ---LSMDAIQ 
Cyp11b2    VAELISQGS- ---------- ---------- ---------- ---LPLDAIK 
Cyp17      IQAKMNAENN NT-------- ---------- -----GEGQD PSVFSDKHIL 
Cyp19      IFAERRGD-- ---------- ---------- ---------- ---LTKENVN 
Cyp20      DSLTQG---- ---------- ---------- ---------- --KLNEQQIL 
Cyp21      LQGVEK-QRD ---------- ---------- -----G--KD EERLHEGHVH 
Cyp24      LCDIYQQDH- ---------- ---------- ---------- ---LSKKELY 
Cyp26a1    IEHSWE---- ---------- ---------- ---------R GERLDMQALK 
Cyp26b1    IESSKE---- ---------- ---------- ---------H GKEMTMQELK 
Cyp26c1    INSARE---- ---------- ---------- ---------L GHEPSVQELK 
Cyp27a1    LHFLLTNEL- ---------- ---------- ---------- ---LSTQETI 
Cyp27b1    LTHFLFREK- ---------- ---------- ---------- ---VSVQSIV 
Cyp39      QAILEV---- ---------- ---------- ---------V ETETR-QYSP 
Cyp46      LKAEEG---- ---------- ---------- ---------- --AQDDEVLL 
Cyp51      LDSTYK---- ---------- ---------- ---------D GRPLTDEEIS 
CYP1A1h    IEHCQEKQL- ---------- ---------- ------DENA NVQLSDEKII 
CYP1A2h    FKHSKKG--- ---------- ---------- ------PRAS GNLIPQEKIV 
CYP1B1h    ILSAEKKAAG ---------- ---------- -----DSHGG GARLDLENVP 
CYP2A6     LIRMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLV 
CYP2A7     LIHMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLM 
CYP2A13    LIRMQEEE-- ---------- ---------- ------KNPN TE-FYLKNLV 
CYP2B6     LLHMEKEK-- ---------- ---------- ------SNAH SE-FSHQNLN 
CYP2C8     LIKMEQEK-- ---------- ---------- ------DNQK SE-FNIENLV 
CYP2C9     LMKMEKEK-- ---------- ---------- ------HNQP SE-FTIESLE 
CYP2C18    LIKMEQEK-- ---------- ---------- ------HNQQ SE-FTVESLI 
CYP2C19    LIKMEKEK-- ---------- ---------- ------QNQQ SE-FTIENLV 
CYP2D6     LAEMEKAK-- ---------- ---------- ------GNPE SS-FNDENLR 
CYP2E1h    LVEMEKEK-- ---------- ---------- ------HSAE RL-YTMDGIT 
CYP2F1     LTKMAEEK-- ---------- ---------- ------EDPL SH-FHMDTLL 
CYP2G2P    LIKMHQDK-- ---------- ---------- ------NNPR TE-FNLKNLV 
CYP2J2     LKEMSKHT-- ---------- ---------- ------GNPT SS-FHEENLI 
CYP2R1h    LDEMDQGK-- ---------- ---------- ------NDPS ST-FSKENLI 
CYP2S1h    LLKMAQEE-- ---------- ---------- ------QNPG TE-FTNKNML 
CYP2T2P    TRWVRHGQ-- ---------- ---------- ------QDPE SH-FQETSVM 
CYP2U1h    LLHMEEER-- ---------- ---------- ------KNNS NSSFDEEYLF 
CYP3A4     IDSQN-S--- ---------- ---------- -----KETES HKALSDLELV 
CYP3A5     IDSQN-S--- ---------- ---------- -----KETES HKALSDLELA 
CYP3A7     IDSQN-S--- ---------- ---------- -----KDSET HKALSDLELM 
CYP3A43    IDSQN-S--- ---------- ---------- -----KETKS HKALSDLELV 
CYP4A11    LLAKME---- ---------- ---------- ---------N GSILSDKDLR 
CYP4A22    LLAKME---- ---------- ---------- ---------N GSILSDKDLR 
CYP4B1h    LGARDE---- ---------- ---------- ---------D DIKLSDADLR 
CYP4F2     LLSKDE---- ---------- ---------- ---------D GKKLSDEDIR 
CYP4F3     LLSKDE---- ---------- ---------- ---------D GKKLSDEDIR 
CYP4F8     LLSEDK---- ---------- ---------- ---------N GKELSDEDIR 
CYP4F11    LLSKDE---- ---------- ---------- ---------D GKELSDEDIR 
CYP4F12    LLSKDE---- ---------- ---------- ---------D GKALSDEDIR 
CYP4F22    LLARDE---- ---------- ---------- ---------D GKELSDEDIR 
CYP4F23P   LLAKDE---- ---------- ---------- ---------N GKKLSDENIR 
CYP4V2     LSVTDD---- ---------- ---------- ---------E GNRLSHEDIR 
CYP4X1h    LSAKD----- ---------- ---------- --------ES GSSFSDIDVH 
CYP4Z1     LSAKV----- ---------- ---------- --------EN TKDFSEADLQ 
CYP5A1h    LDARHSASPM GVQDFDIVRD VFSSTGCKPN PSRQHQPSPM ARPLTVDEIV 
CYP7A1h    RMFLND---- ---------- ---------- ---------T LSTFDDLEKA 
CYP7B1h    RQDVLE---- ---------- ---------- ---------K YYVHEDLEIG 
CYP8A1h    SYLLHL---- ---------- ---------- ---------E EMGVSEEMQA 
CYP8B1h    NMLQFL---- ---------- ---------- ---------R EQGVPSAMQD 
CYP11A1h   LYRLLGDSK- ---------- ---------- ---------- ---MSFEDIK 
CYP11B1h   VAELLLNAE- ---------- ---------- ---------- ---LSPDAIK 
CYP11B2h   VAELLLKAE- ---------- ---------- ---------- ---LSLEAIK 
CYP17h     MQAKMNSDNG NA-------- ---------- -----GPDQD SELLSDNHIL 
CYP19h     ILAEKRGD-- ---------- ---------- ---------- ---LTRENVN 
CYP20h     DSLVQG---- ---------- ---------- ---------- --NLNDQQIL 
CYP21A2h   LQGVAQ-PSM ---------- ---------- -----E--EG SGQLLEGHVH 
CYP24h     LCDIYHQNR- ---------- ---------- ---------- ---LSKKELY 
CYP26A1h   IEHSWE---- ---------- ---------- ---------R GERLDMQALK 
CYP26B1h   IESSKE---- ---------- ---------- ---------H GKEMTMQELK 
CYP26C1h   IHSARE---- ---------- ---------- ---------L GHEPSMQELK 
CYP27A1h   LHFLLASGQ- ---------- ---------- ---------- ---LSPREAM 
CYP27B1h   LTHFLFREE- ---------- ---------- ---------- ---LPAQSIL 
CYP27C1h   LTYLFLSQA- ---------- ---------- ---------- ---LTLQEIY 
CYP39A1h   QATLDI---- ---------- ---------- ---------V ETETSKENSP 
CYP46h     LKAEEG---- ---------- ---------- ---------- --AQDDEGLL 
CYP51h     LDATYK---- ---------- ---------- ---------D GRPLTDDEVA 

Cyp1a1     TIVLDLFGAG FDTVTTAISW SLMYLVTNPR VQRKIQEELD TVIG--RDR- 
Cyp1a2     NIVNDIFGAG FDTVTTAITW SILLLVTWPN VQRKIHEELD TVVG--RDR- 
Cyp1b1     ATITDIFGAS QDTLSTALLW LLILFTRYPD VQARVQAELD QVVG--RDR- 
Cyp2a4     LTTQNLFFAG TETGSTTLRY GFLLLMKYPD IEAKVHEEID RVIG--RNR- 
Cyp2a5     LTTLNLFFAG TETVSTTLRY GFLLLMKHPD IEAKVHEEID RVIG--RNR- 
Cyp2a12    MTSLNLFFAG SETVSSTLRY GFLLLMKHPD VEAKVHEEID RVIG--RNR- 
Cyp2a22    MTSLNLFFAG SETVSSLLRY GFLLLMKHPD VEAKVHEEID RVIG--RNR- 
Cyp2b9     MSVLSLFFAG TETTSATLHY GVLLMLKYPH VTEKVQKEID QVIG--SHR- 
Cyp2b10    MSVLSLFFAG TETSSTTLRY GFLLMLKYPH VAEKVQKEID QVIG--SHR- 
Cyp2b13    MSVLSLFFAG TETTSTTLCC GFLLMLMYPH VAGKVQKEID QVIG--SHR- 
Cyp2b19    ISVLSLFFAG TETTSTTLRY SFLIMLKYPH VAEKVQKEID QVIG--SHR- 
Cyp2b23    ISVLSLFFAG TETTSTTLRY GFLLMLKYPH VAEKVQKEID QVIS--AHH- 
Cyp2c29    STINDLFGAG TETTSTTLRY ALLLLLKYPD VTAKVQEEID RVVG--RHR- 
Cyp2c37    ITVTDLFSAG TETTSTTLRY ALLLLLKYPH VTAKVQKEIE HVIG--KHR- 
Cyp2c38    CTINNLFAAG TETTSTTLRY ALLLLMKYPD VTAKVQEEID HVVG--RHR- 
Cyp2c39    CTINNLFAAG TETTSTTLRY ALLLLMKYPD VTAKVQEEID HVIG--RHR- 
Cyp2c40    TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c44    ICGSNLFTAG TETTSTTLRF GLLLLVKHPE VQAKVHEELD RVIG--RHQ- 
Cyp2c50    ITVTDLFSAG TETTSTTLRY ALLLLLKYPH VTAKVQEEIE HVIG--KHR- 
Cyp2c54    ITVTDLFIGG TESMSTTLRY ALLLLLKYPH VTAKVQEEIE HVIG--KHR- 
Cyp2c55    ATVTDIFVAG TETTNITLRY GLLLLLKHTE VTAKVQAEID HVIG--RHR- 
Cyp2c65    FTASDLFAAG TETTSTTLRY SLLLLLKYPE VTAKVQEEID CVIG--RHR- 
Cyp2c66    FTASDLFAAG TETTSTTLRY SLLLLLKYPE VTAKVQAEID CVIG--RHR- 
Cyp2c67    TLVTDLVFGG TESLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c68    TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c69    TLVTDLVFGG TETLSSTMRF ALLLLMKHTH ITAKVQEEID NVIG--RHR- 
Cyp2c70    VSIGDLFGAG TETTSSTVKY GLLLLLKYPE VTAKIQEEIA HVIG--RHR- 
Cyp2ac1    ALVSNLFTAR TKTTASTLHW GIILMMLYPE VQSKVRGEII KVVG--SAQ- 
Cyp2ab1    QVVIDLFLGG TDTTATTLHW ALIYLVHHRA IQRRVQQELD EMLG--AAQ- 
Cyp2d9     MVVRDLFGAG MLTTSTTLSW ALMLMILHPD VQRRVQQEID EVIG--QVR- 
Cyp2d10    MVVLDLFTAG MVTTSTTLSW ALLLMILHPD VQRRVQQEID AVIG--QVR- 
Cyp2d34    MVVSDLFTAG MVTTSTTLSC ALLLMILHPD VQRRVQQEID AVIG--QVR- 
Cyp2d11    MVVLDLFTAG MVTTSTTLSW ALLLMILHPD VQRRVQQEID AVIG--QVQ- 
Cyp2d12    MVVIDLFTAG ILTTSTTLSW ALLLMILHPD VQRRVQQEID EVIG--QVR- 
Cyp2d13    LVVFDLFGAG IVTSSITLTW ALLLMILHPD VQRRVQEEID EVIG--QVR- 
Cyp2d40    LVVLDLFGGG IVTTSATLTW ALLLMILHPD VQRRVQEEID EVIG--QAR- 
Cyp2d22    TVVGDLFSAG MVTTSTTLSW ALMLMILHPD VQRRVQQEID EVIG--QVQ- 
Cyp2d26    IVVIDLFMAG MVTTSTTLSW ALLLMILHPD VQRRVHQEID EVIG--HVR- 
Cyp2e1     VTLADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIG--PSR- 
Cyp2f2     MTTHNLLFGG TETVGTTLRH AFLILMKYPK VQARVQEEID RVVG--RSR- 
Cyp2g1     LTTLNLFFAG TETVSSTLRY GFLLLLKYPE VEAKIHEEIN QVIG--THR- 
Cyp2j5     STTLDLFLGG TETTSSTLRW ALLYMSSYPE IQENVQAEID RVIG--HKR- 
Cyp2j6     CSTLDLFFAG TETTSTTLRW ALLYMALYPE VQEKVQAEID RVIG--QKR- 
Cyp2j7     CSCLDLFIAG TETSSTALRW ALLYMTLNPE VQERVHSEID GVIG--QWR- 
Cyp2j8     CTTLDLFFAG TETTSTALRW ALLYITVNPE VQEKVHSEID RVIG--QGR- 
Cyp2j9     CSTLDLFFAG TETTSTTLRW ALLCMALYPE VQEKMQAEID RVIG--QAR- 
Cyp2j13    CSTLDLFLAG TETTSSTLRW ALLYMALYPE VQENVQAEID RVIG--QSK- 
Cyp2j12    NSTLDLFFAG SETTTNTLRW ALLYITTNPE VQEKVHSEID RVIG--HGR- 
cyp2j11    CTALDLFFAG TETTSNTLRW ALLYITVNPE VQEKVHSEID RVIG--HGR- 
Cyp2r1     FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVHKEID LIVG--HNR- 
Cyp2s1     MTVTYLLFAG TMTIGATIRY ALLLLLRYPQ VQQRVREELI QELG--PGR- 
Cyp2t4     MTTHDLFFGG TETTSTTLRY GLLIMLKYPE VAAKVQEELD ATVG--RTW- 
Cyp2U1     YIIGDLFIAG TDTTTNSLLW CLLYMSLNPD VQKKVHEEIE RVIG--CDR- 
Cyp2w1     ACTLDMVMAG TETTAATLQW AVFLMVKHPH VQGRVQEELD RVLG--PGQ- 
CYP2W1h    ACTLDMVMAG TETTSATLQW AALLMGRHPD VQGRVQEELD RVLG--PGR- 
Cyp3a11    AQSIIFIFAG YETTSSTLSF TLHSLATHPD IQKKLQDEID EALP---NKA 
Cyp3a13    AQSVIFIFAG YETTSSALSF ALYLLAIHPD VQKKLQDEID AALP---NKA 
Cyp3a16    AQSIIFIFAG YETTSSILSF TVYSLATHPD IQKKLQEEID EALP---NKA 
Cyp3a25    AQAVIFIFGG YDATSTSISL IMYELATHPD VQKKLQDEID RTLP---NKA 
Cyp3a59    AQAVIFIFGG YDATSTSISL IMYELATHPD VQKKLQDEID RTLP---NKA 
Cyp3a57    AQTLIFIFGG YDGTSTSISF IMYELATHPD VQKKLQDEID RALP---NKA 
Cyp3a41    AQSIVFIFAG YETTSSTLSF TLYCLATHPD IQKKLQEEID ETLP---NKA 
Cyp3a44    VQSIIFISAG YETTSSTLSF TLYCLATHPD IQKKLQAEID KALP---NKA 
Cyp4a10    AEVDTFMFEG HDTTASGVSW IFYALATHPD HQQRCREEVQ SLLG---DGS 
Cyp4a31    AEVDTFMIEG HDTTASGVSW IFYALATHPE HQQRCREEVQ SLLG---DGS 
Cyp4a32    AEVDTFMFEG HDTTASGVSW IFYALATHPE HQQRCREEVQ SLLG---DGS 
Cyp4a12a   AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ SLLG---DGT 
Cyp4a12b   AEVDTFMFEG HDTTASGISW IFYALATNPE HQQRCRKEIQ SLLG---DGA 
Cyp4a14    AEVDTFMFEG HDTTASGISW IFYALATHPE HQQRCREEVQ SILG---DGT 
Cyp4a30b   AEMDTFMFEG HNTTASGISW IFYALATHPE HQQRCREEVK SILG---NGT 
Cyp4a29    AEVDSLMFGG HDTPASGISW VFYALATHPD HQQRCREEVQ SLLG---DGS 
Cyp4b1     AEVDTFMFEG HDTTTSGISW FLYCMALYPM HQQRCREEVR EILG---DRD 
Cyp4f13    AEADTFMFGG HDTTTSALSW ILYNLARHPE YQERCRQEVQ ELLR---DRD 
Cyp4f14    AEADTFMFEG HDTTASGLSW ILYNLARHPE YQERCRQEVQ ELLR---GRE 
Cyp4f15    AEADTFMFEG HDTTASGLSW ILYNLARHPE YQERCRQEVQ ELLR---DRE 
Cyp4f16    AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---DRE 
Cyp4f17    AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---GRE 
Cyp4f18    AEADTFMFGG HDTTASGLSW ILYNLARHPE YQERCRQEVR ELLR---DRE 
Cyp4f37    AEADTFMFGG HDTTASALSW ILYNLARHPE YQERCRQEVQ ELLR---GRE 
Cyp4f39    AEADTFMFEG HDTTSSGLSW ALFNLAKYPE YQEKCREEIQ EVMK---GRE 
Cyp4f40    AEADTFMFRG HDTTASGLSW ILYNLARHPE HQERCRQEVQ ELLR---DRD 
Cyp4v3     EEVDTFMFEG HDTTAAAINW SLYLLGTNPE VQRKVDQELD EVFG---RSH 
Cyp4x1     AEVNTFMWAG HDASAASISW LLYCLALNPE HQDRCRTEIR SILG---DGS 
Cyp5a1     GQAFLFLIAG HEVITNTLSF ITYLLATHPD CQERLLKEVD LFMG---KHP 
Cyp7a1     KTHLVILWAS QANTIPATFW SLFQMIRSPE AMKAASEEVN GSLQSAGQEL 
Cyp7b1     AHHLGFLWAS LANTIPAMFW AMYYILRHPE AMEALRDEID SFLQSTGQKK 
Cyp8a1     RALVLQLWAT QGNMGPTAFW LLLFLLKNPE ALAAVRAELK HTVWQAEQPV 
Cyp8b1     KFNFMMLWAS QGNTGPTCFW VLLFLLKHQD AMKAVREEAT RVMGKARLEA 
Cyp11a1    ANITEMLAGG VDTTSMTLQW NLYEMAHNLK VQEMLRAEVL AARR--QAQ- 
Cyp11b1    ANSMELIAGS TDTTSTPLVM TFFELARNPD VQQALRQESL AAEA--SIA- 
Cyp11b2    ANSMELTAGS VDTTAIPLVM TLFELARNPD VQKALRQESL AAEA--SIA- 
Cyp17      VTVGDIFGAG IETTSSVLNW ILAFLVHNPE VKRKIQKEID QYVG--FSR- 
Cyp19      QCILEMLIAA PDTMSVTLYF MLLLVAEYPE VEAAILKEIH TVVG---DR- 
Cyp20      EDCVVFSLAS CIITARLCTW TIHFLTTTGE VQKKLCKEID QVLG---EG- 
Cyp21      MSVVDLFIGG TETTATTLSW AVAFLLHHPE IQKRLQEELD LKLG--PGS- 
Cyp24      AAVTELQLAA VETTANSLMW ILYNLSRNPQ VQQRLLREIQ SVLP--DNQ- 
Cyp26a1    QSSTELLFGG HETTASAATS LITYLGLYPH VLQKVREEIK SKGLLCKSNQ 
Cyp26b1    DGTLELIFAA YATTASASTS LIMQLLKHPA VLEKLREELR AQGLLHGGGC 
Cyp26c1    ELAVELLFAA FFTTASASTS LILLLLQHPA AITKIQQELS AQGLGRACTC 
Cyp27a1    GTFPELLLAG VDTTSNTLTW ALYHLSKSPE IQEALHKEVT GVVP--FGK- 
Cyp27b1    GNVTELLLAG VDTVSNTLSW TLYELSRHPD VQTALHSEIT AGTR-GSCA- 
Cyp39      NYGLVVLWAA LANAPPIAFW TLGYILSHPD IHRTVLESIS SVFGTAGKDK 
Cyp46      DNFVTFFIAG HETSANHLAF TVMELSRQPE IVARLQAEVD EVVG---SKR 
Cyp51      GMLIGLLLAG QHTSSTTSAW MGFFLAKDKP LQEKCYLEQK AVCGEDLPP- 
CYP1A1h    NIVLDLFGAG FDTVTTAISW SLMYLVMNPR VQRKIQEELD TVIG--RSR- 
CYP1A2h    NLVNDIFGAG FDTVTTAISW SLMYLVTKPE IQRKIQKELD TVIG--RER- 
CYP1B1h    ATITDIFGAS QDTLSTALQW LLLLFTRYPD VQTRVQAELD QVVG--RDR- 
CYP2A6     MTTLNLFIGG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- 
CYP2A7     MSTLNLFIAG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- 
CYP2A13    MTTLNLFFAG TETVSTTLRY GFLLLMKHPE VEAKVHEEID RVIG--KNR- 
CYP2B6     LNTLSLFFAG TETTSTTLRY GFLLMLKYPH VAERVYREIE QVIG--PHR- 
CYP2C8     GTVADLFVAG TETTSTTLRY GLLLLLKHPE VTAKVQEEID HVIG--RHR- 
CYP2C9     NTAVDLFGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVIG--RNR- 
CYP2C18    ATVTDMFGAG TETTSTTLRY GLLLLLKYPE VTAKVQEEIE CVVG--RNR- 
CYP2C19    ITAADLLGAG TETTSTTLRY ALLLLLKHPE VTAKVQEEIE RVIG--RNR- 
CYP2D6     IVVADLFSAG MVTTSTTLAW GLLLMILHPD VQRRVQQEID DVIG--QVR- 
CYP2E1h    VTVADLFFAG TETTSTTLRY GLLILMKYPE IEEKLHEEID RVIG--PSR- 
CYP2F1     MTTHNLLFGG TKTVSTTLHH AFLALMKYPK VQARVQEEID LVVG--RAR- 
CYP2G2P    LTTLNLFFAG TETVSSTLRY GFLLLMKHPE VEAKIHEEIN QVIG--PHR- 
CYP2J2     CSTLDLFFAG TETTSTTLRW ALLYMALYPE IQEKVQVEID RVIG--QGQ- 
CYP2R1h    FSVGELIIAG TETTTNVLRW AILFMALYPN IQGQVQKEID LIMG--PNG- 
CYP2S1h    MTVIYLLFAG TMTVSTTVGY TLLLLMKYPH VQKWVREELN RELG--AGQ- 
CYP2T2P    TT--HFFFGV TETTSTTLCY GLLILLKYLE VAAKVQELDP VVG---WRP- 
CYP2U1h    YIIGDLFIAG TDTTTNSLLW CLLYMSLNPD VQEKVHEEIE RVIG--ANR- 
CYP3A4     AQSIIFIFAG YETTSSVLSF IMYELATHPD VQQKLQEEID AVLP---NKA 
CYP3A5     AQSIIFIFAG YETTSSVLSF TLYELATHPD VQQKLQKEID AVLP---NKA 
CYP3A7     AQSIIFIFAG YETTSSVLSF IIYELATHPD VQQKVQKEID TVLP---NKA 
CYP3A43    AQSIIIIFAA YDTTSTTLPF IMYELATHPD VQQKLQEEID AVLP---NKA 
CYP4A11    AEVDTFMFEG HDTTASGISW ILYALATHPK HQERCREEIH SLLG---DGA 
CYP4A22    AEVDTFMFEG HDTTASGISW ILYALATHPK HQERCREEIH GLLG---DGA 
CYP4B1h    AEVDTFMFEG HDTTTSGISW FLYCMALYPE HQHRCREEVR EILG---DQD 
CYP4F2     AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQERCRQEVQ ELLK---DRE 
CYP4F3     AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQERCRQEVQ ELLK---DRE 
CYP4F8     AEADTFMFGG HDTTASGLSW VLYNLARHPE YQERCRQEVQ ELLK---DRE 
CYP4F11    AEADTFMFEG HDTTASGLSW VLYHLAKHPE YQEQCRQEVQ ELLK---DRE 
CYP4F12    AEADTFMFGG HDTTASGLSW VLYNLARHPE YQERCRQEVQ ELLK---DRD 
CYP4F22    AEADTFMFEG HDTTSSGISW MLFNLAKYPE YQEKCREEIQ EVMK---GRE 
CYP4F23P   AEADTFMSGG HDTTASGLSW VLYNLARYPE YQEHCRQEVQ ELLK---NGD 
CYP4V2     EEVDTFMFEG HDTTAAAINW SLYLLGSNPE VQKKVDHELD DVK-----SD 
CYP4X1h    SEVSTFLLAG HDTLAASISW ILYCLALNPE HQERCREEVR GILG---DGS 
CYP4Z1     AEVKTFMFAG HDTTSSAISW ILYCLAKYPE HQQRCRDEIR ELLG---DGS 
CYP5A1h    GQAFIFLIAG YEIITNTLSF ATYLLATNPD CQEKLLREVD VFKE---KHM 
CYP7A1h    KTHLVVLWAS QANTIPATFW SLFQMIRNPE AMKAATEEVK RTLENAGQKV 
CYP7B1h    AHHLGFLWAS VANTIPTMFW AMYYLLRHPE AMAAVRDEID RLLQSTGQKK 
CYP8A1h    RALVLQLWAT QGNMGPAAFW LLLFLLKNPE ALAAVRGELE SILWQAEQPV 
CYP8B1h    KFNFMMLWAS QGNTGPTSFW ALLYLLKHPE AIRAVREEAT QVLGEARLET 
CYP11A1h   ANVTEMLAGG VDTTSMTLQW HLYEMARNLK VQDMLRAEVL AARH--QAQ- 
CYP11B1h   ANSMELTAGS VDTTVFPLLM TLFELARNPN VQQALRQESL AAAA--SIS- 
CYP11B2h   ANSMELTAGS VDTTAFPLLM TLFELARNPD VQQILRQESL AAAA--SIS- 
CYP17h     TTIGDIFGAG VETTTSVVKW TLAFLLHNPQ VKKKLYEEID QNVG--FSR- 
CYP19h     QCILEMLIAA PDTMSVSLFF MLFLIAKHPN VEEAIIKEIQ TVIG---ER- 
CYP20h     EDSMIFSLAS CIITAKLCTW AICFLTTSEE VQKKLYEEIN QVFG---NG- 
CYP21A2h   MAAVDLLIGG TETTANTLSW AVVFLLHHPE IQQRLQEELD HELG--PGAS 
CYP24h     AAVTELQLAA VETTANSLMW ILYNLSRNPQ VQQKLLKEIQ SVLP--ENQ- 
CYP26A1h   QSSTELLFGG HETTASAATS LITYLGLYPH VLQKVREELK SKGLLCKSNQ 
CYP26B1h   DGTLELIFAA YATTASASTS LIMQLLKHPT VLEKLRDELR AHGILHSGGC 
CYP26C1h   ESAVELLFAA FFTTASASTS LVLLLLQHPA AIAKIREELV AQGLGRACGC 
CYP27A1h   GSLPELLMAG VDTTSNTLTW ALYHLSKDPE IQEALHEEVV GVVP--AGQ- 
CYP27B1h   GNVTELLLAG VDTVSNTLSW ALYELSRHPE VQTALHSEIT AALSPGSSA- 
CYP27C1h   ANVTEMLLAG VDTTSFTLSW TVYLLARHPE VQQTVYREIV KNLG--ERH- 
CYP39A1h   NYGLLLLWAS LSNAVPVAFW TLAYVLSHPD IHKAIMEGIS SVFGKAGKDK 
CYP46h     DNFVTFFIAG HETSANHLAF TVMELSRQPE IVARLQAEVD EVIG---SKR 
CYP51h     GMLIGLLLAG QHTSSTTSAW MGFFLARDKT LQKKCYLEQK TVCGENLPP- 

Cyp1a1     ---------- --------QP RLS------- DRPQLPYLEA FILETFRHS- 
Cyp1a2     ---------- --------QP RLS------- DRPQLPYLEA FILEIYRYT- 
Cyp1b1     ---------- --------LP CMS------- DQPNLPYVMA FLYESMRFS- 
Cyp2a4     ---------- --------QP KYE------- DRMKMPYTEA VIHEIQRFA- 
Cyp2a5     ---------- --------QP KYE------- DRMKMPYTEA VIHEIQRFA- 
Cyp2a12    ---------- --------QP QYE------- DHMKMPYTQA VINEIQRFS- 
Cyp2a22    ---------- --------QP QYE------- DHMKMPYTQA VIHEIQRFS- 
Cyp2b9     ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- 
Cyp2b10    ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- 
Cyp2b13    ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFS- 
Cyp2b19    ---------- --------LP TLD------- DRTKMPYTDA VIHEIQRFT- 
Cyp2b23    ---------- --------VP TLE------- DRIKMPYTEA VIHEIQRFS- 
Cyp2c29    ---------- --------SP CMQ------- DRSHMPYTDA MIHEVQRFI- 
Cyp2c37    ---------- --------SP CMQ------- DRSRMPYTDA MIHEVQRFI- 
Cyp2c38    ---------- --------SP CMQ------- DRSHMPYTDA MIHEVQRFI- 
Cyp2c39    ---------- --------SP CMQ------- DRNHMPYTDA MIHEVQRFI- 
Cyp2c40    ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYI- 
Cyp2c44    ---------- --------PP SMK------- DKMKLPYTDA VLHEIQRYI- 
Cyp2c50    ---------- --------SP CMQ------- DRSRMPYTDA MIHEVQRFI- 
Cyp2c54    ---------- --------RP CMQ------- DRSHMPYTNA MIHEVQRFI- 
Cyp2c55    ---------- --------SP CMQ------- DRTRMPYTDA MVHEIQRYI- 
Cyp2c65    ---------- --------SP CMQ------- DRHSMPYTDA VLHEIQRYI- 
Cyp2c66    ---------- --------SP CMQ------- DRHSMPYTDA VLHEIQRYI- 
Cyp2c67    ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYV- 
Cyp2c68    ---------- --------SP CMQ------- DRNHMPYTNA MVHEVQRYI- 
Cyp2c69    ---------- --------SP CMQ------- DRKHMPYTNA MVHEVQRYV- 
Cyp2c70    ---------- --------RP TMQ------- DRNHMPYTDA VLHEIQRYI- 
Cyp2ac1    ---------- ---------P RIE------- HRIQMPYTDT VIHEIERVA- 
Cyp2ab1    ---------- --------TI CYE------- DRERLPYTRA VLHEVQRLS- 
Cyp2d9     ---------- --------HP EMA------- DQAHMPYTNA VIHEVQRFG- 
Cyp2d10    ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFG- 
Cyp2d34    ---------- --------CP EMA------- DQARMPYTNA VIHEVQRFG- 
Cyp2d11    ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFGT 
Cyp2d12    ---------- --------HP EMA------- DQAHMPYTNA VIHEVQRFG- 
Cyp2d13    ---------- --------CP EMA------- DQAHMPYTNA VIHEVQRFA- 
Cyp2d40    ---------- --------RP EMA------- DQARMPYTNA VIHEVQRFA- 
Cyp2d22    ---------- --------CP EMA------- DQARMPYTNA VIHEVQRFA- 
Cyp2d26    ---------- --------HP EMA------- DQARMPYTNA VIHEVQRFA- 
Cyp2e1     ---------- --------AP AVR------- DRMNMPYMDA VVHEIQRFI- 
Cyp2f2     ---------- --------MP TLE------- DRTSMPYTDA VIHEVQRFA- 
Cyp2g1     ---------- --------TP RVD------- DRAKMPYTDA VIHEIQRLT- 
Cyp2j5     ---------- --------QV SLS------- DRESMPYTNA VIHEVQRMG- 
Cyp2j6     ---------- --------AA RLA------- DRESMPYTNA VIHEVRRMG- 
Cyp2j7     ---------- --------QP STG------- DRDSMPYTNA VIHEVLRMG- 
Cyp2j8     ---------- --------HP TID------- DRDSMPYTNA VIHEVLRMG- 
Cyp2j9     ---------- --------QP NLA------- DRDSMPYTNA VIHEVQRMG- 
Cyp2j13    ---------- --------HP SLA------- DRDSMPYTNA VVHEILRMG- 
Cyp2j12    ---------- --------QP STD------- DRDSMPYTNA VIHEVLRMG- 
cyp2j11    ---------- --------HP TLD------- DQDSMPYTNA VIHEVLRMG- 
Cyp2r1     ---------- --------RP SWE------- YKCKMPYTEA VLHEVLRFC- 
Cyp2s1     ---------- --------AP SLS------- DRVRLPYTDA VLHEAQRLL- 
Cyp2t4     ---------- --------AP RIE------- DRARLPYTNA VLHEIQRFI- 
Cyp2U1     ---------- --------AP SLT------- DKAQMPYTEA TIMEVQRLS- 
Cyp2w1     ---------- --------LP QPE------- HQRALPYTSA VLHEVQRYI- 
CYP2W1h    ---------- --------TP RLE------- DQQALPYTSA VLHEVQRFI- 
Cyp3a11    PP-------- --------TY DTVME----- ----MEYLDM VLNETLRLYP 
Cyp3a13    PA-------- --------TY DTLLQ----- ----MEYLDM VVNETLRLYP 
Cyp3a16    PP-------- --------TY DTVMA----- ----MEYLDM VLNETLRLYP 
Cyp3a25    PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP 
Cyp3a59    PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP 
Cyp3a57    PV-------- --------TY DALMD----- ----MEYLDM VVNESLRLYP 
Cyp3a41    PP-------- --------TY DTVME----- ----MEYLDM VLNETLRLYP 
Cyp3a44    TP-------- --------TC DTVME----- ----MEYLDM VLNETLRLYP 
Cyp4a10    S--------- ---------I TWD------- HLDQIPYTTM CIKEALRLYP 
Cyp4a31    S--------- ---------I T-D------- HLDQIPYTTM CIKEALRLYP 
Cyp4a32    S--------- ---------I TWD------- HLDQIPYTTM CIKEALRLYP 
Cyp4a12a   S--------- ---------I TWN------- DLDKMPYTTM CIKEALRIYP 
Cyp4a12b   S--------- ---------I TWN------- DLDKMPYTTM CIKEALRIYP 
Cyp4a14    S--------- ---------V TWD------- HLGQMPYTTM CIKEALRLYP 
Cyp4a30b   S--------- ---------V TN-------- HLDQMPYTTM CIKEALRLYP 
Cyp4a29    P--------- ---------I TWD------- HLHQMPYTTM CIKEALRLYP 
Cyp4b1     S--------- ---------F QWD------- DLAQMTYLTM CMKECFRLYP 
Cyp4f13    SE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f14    PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f15    ST-------- --------EI ECSCAVFLRD DLAQLPFLTM CIKESLRLHP 
Cyp4f16    PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHS 
Cyp4f17    PQ-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f18    PE-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f37    PQ-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4f39    LE-------- --------EL DWD------- DLTQLPFTTM CIKESLRQFP 
Cyp4f40    PK-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
Cyp4v3     RP-------- --------VT LED------- -LKKLKYLDC VIKETLRVFP 
Cyp4x1     S--------- ---------I TWE------- QLDEMSYTTM CIKETLRLIP 
Cyp5a1     AP-------- --------EY HSLQEG---- ----LPYLDM VISETLRMYP 
Cyp7a1     SS-------- ----GGNAIY LDQE------ QLNNLPVLDS IIKEALRLSS 
Cyp7b1     G--------- ----PGISVH FTRE------ QLDSLVCLES TILEVLRLCS 
Cyp8a1     S--------- ------QMTT LPQK------ ILDSMPVLDS VLNETLRLTA 
Cyp8b1     K--------- ------KSFT FTPS------ ALKHTPVLDS VMEESLRLCA 
Cyp11a1    ---------- --------GD MAK------- MVQLVPLLKA SIKETLRLH- 
Cyp11b1    ---------- --------AN PQK------- AMSDLPLLRA ALKETLRLY- 
Cyp11b2    ---------- --------AN PQK------- AMSDLPLLRA ALKETLRLY- 
Cyp17      ---------- --------TP SFN------- DRTHLLMLEA TIREVLRIR- 
Cyp19      ---------- --------DI KIE------- DIQNLKVVEN FINESMRYQ- 
Cyp20      PI-------- --------TS EK-------- -IEQLSYCQQ VLFETVRTAK 
Cyp21      ---------- --------QL LYR------- NRMQLPLLMA TIAEVLRLR- 
Cyp24      ---------- --------TP RAE------- DVRNMPYLKA CLKESMRLT- 
Cyp26a1    D--------- --------NK LDME------ TLEQLKYIGC VIKETLRLNP 
Cyp26b1    P--------- ------CEGT LRLD------ TLSSLRYLDC VIKEVMRLFT 
Cyp26c1    TPRASGS--- -PPDCGCEPD LSLA------ MLGRLRYVDC VVKEVLRLLP 
Cyp27a1    ---------- --------VP QHK------- DFAHMPLLKA VIKETLRLY- 
Cyp27b1    ---------- --------HP HGT------- ALSQLPLLKA VIKEVLRLY- 
Cyp39      ---------- --------IK VSED------ DLKKLLIIKW CILESVRLRA 
Cyp46      HL-------- --------DY ED-------- -LGRLQYLSQ VLKESLRLYP 
Cyp51      ---------- ---------- LTYD------ QLKDLNLLDR CIKETLRLRP 
CYP1A1h    ---------- --------RP RLS------- DRSHLPYMEA FILETFRHS- 
CYP1A2h    ---------- --------RP RLS------- DRPQLPYLEA FILETFRHS- 
CYP1B1h    ---------- --------LP CMG------- DQPNLPYVLA FLYEAMRFS- 
CYP2A6     ---------- --------QP KFE------- DRAKMPYMEA VIHEIQRFG- 
CYP2A7     ---------- --------QP KFE------- DRTKMPYMEA VIHEIQRFG- 
CYP2A13    ---------- --------QP KFE------- DRAKMPYTEA VIHEIQRFG- 
CYP2B6     ---------- --------PP ELH------- DRAKMPYTEA VIYEIQRFS- 
CYP2C8     ---------- --------SP CMQ------- DRSHMPYTDA VVHEIQRYS- 
CYP2C9     ---------- --------SP CMQ------- DRSHMPYTDA VVHEVQRYI- 
CYP2C18    ---------- --------SP CMQ------- DRSHMPYTDA VVHEIQRYI- 
CYP2C19    ---------- --------SP CMQ------- DRGHMPYTDA VVHEVQRYI- 
CYP2D6     ---------- --------RP EMG------- DQAHMPYTTA VIHEVQRFG- 
CYP2E1h    ---------- --------IP AIK------- DRQEMPYMDA VVHEIQRFI- 
CYP2F1     ---------- --------LP ALK------- DRAAMPYTDA VIHEVQRFA- 
CYP2G2P    ---------- --------LP RVD------- DRVKMPYTDA VIHEIQRLV- 
CYP2J2     ---------- --------QP STA------- ARESMPYTNA VIHEVQRMG- 
CYP2R1h    ---------- --------KP SWD------- DKCKMPYTEA VLHEVLRFC- 
CYP2S1h    ---------- --------AP SLG------- DRTRLPYTDA VLHEAQRLL- 
CYP2T2P    ---------- --------AP SLD------- YRVCLPYANA VLLEIQCFI- 
CYP2U1h    ---------- --------AP SLT------- DKAQMPYTEA TIMEVQRLT- 
CYP3A4     PP-------- --------TY DTVLQ----- ----MEYLDM VVNETLRLFP 
CYP3A5     PP-------- --------TY DAVVQ----- ----MEYLDM VVNETLRLFP 
CYP3A7     PP-------- --------TY DTVLQ----- ----LEYLDM VVNETLRLFP 
CYP3A43    PV-------- --------TY DALVQ----- ----MEYLDM VVNETLRLFP 
CYP4A11    S--------- ---------I TWN------- HLDQMPYTTM CIKEALRLYP 
CYP4A22    S--------- ---------I TWN------- HLDQMPYTTM CIKEALRLYP 
CYP4B1h    F--------- ---------F QWD------- DLGKMTYLTM CIKESFRLYP 
CYP4F2     PK-------- --------EI EWD------- DLAHLPFLTM CMKESLRLHP 
CYP4F3     PK-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
CYP4F8     PK-------- --------EI EWD------- DLAQLPFLTM CLKESLRLHP 
CYP4F11    PI-------- --------EI EWD------- DLAQLPFLTM CIKESLRLHP 
CYP4F12    PK-------- --------EI EWD------- DLAQLPFLTM CVKESLRLHP 
CYP4F22    LE-------- --------EL EWD------- DLTQLPFTTM CIKESLRQYP 
CYP4F23P   PK-------- --------EI EWD------- DLAQLPFLTM CLKESLRLHS 
CYP4V2     RP-------- --------AT VED------- -LKKLRYLEC VIKETLRLFP 
CYP4X1h    S--------- ---------I TWD------- QLGEMSYTTM CIKETCRLIP 
CYP4Z1     S--------- ---------I TWE------- HLSQMPYTTM CIKECLRLYA 
CYP5A1h    AP-------- --------EF CSLEEG---- ----LPYLDM VIAETLRMYP 
CYP7A1h    SL-------- ----EGNPIC LSQA------ ELNDLPVLDS IIKESLRLSS 
CYP7B1h    G--------- ----SGFPIH LTRE------ QLDSLICLES SIFEALRLSS 
CYP8A1h    S--------- ------QTTT LPQK------ VLDSTPVLDS VLSESLRLTA 
CYP8B1h    K--------- ------QSFA FKLG------ ALQHTPVLDS VVEETLRLRA 
CYP11A1h   ---------- --------GD MAT------- MLQLVPLLKA SIKETLRLH- 
CYP11B1h   ---------- --------EH PQK------- ATTELPLLRA ALKETLRLY- 
CYP11B2h   ---------- --------EH PQK------- ATTELPLLRA ALKETLRLY- 
CYP17h     ---------- --------TP TIS------- DRNRLLLLEA TIREVLRLR- 
CYP19h     ---------- --------DI KID------- DIQKLKVMEN FIYESMRYQ- 
CYP20h     PV-------- --------TP EK-------- -IEQLRYCQH VLCETVRTAK 
CYP21A2h   SS-------- --------RV PYK------- DRARLPLLNA TIAEVLRLR- 
CYP24h     ---------- --------RP REE------- DLRNMPYLKA CLKESMRLT- 
CYP26A1h   D--------- --------NK LDME------ ILEQLKYIGC VIKETLRLNP 
CYP26B1h   P--------- ------CEGT LRLD------ TLSGLRYLDC VIKEVMRLFT 
CYP26C1h   APGAAGGSEG PPPDCGCEPD LSLA------ ALGRLRYVDC VVKEVLRLLP 
CYP27A1h   ---------- --------VP QHK------- DFAHMPLLKA VLKETLRLY- 
CYP27B1h   ---------- --------YP SAT------- VLSQLPLLKA VVKEVLRLY- 
CYP27C1h   ---------- --------VP TAA------- DVPKVPLVRA LLKETLRLF- 
CYP39A1h   ---------- --------IK VSED------ DLENLLLIKW CVLETIRLKA 
CYP46h     YL-------- --------DF ED-------- -LGRLQYLSQ VLKESLRLYP 
CYP51h     ---------- ---------- LTYD------ QLKDLNLLDR CIKETLRLRP 

Cyp1a1     SFVPFTIPHS TTRDT----- ----SLNGFY IPKGCCVFVN QWQ-VNHDRE 
Cyp1a2     SFVPFTIPHS TTRDT----- ----SLNGFH IPKERCIYIN QWQ-VNHDEK 
Cyp1b1     SFLPVTIPHA TTANT----- ----FVLGYY IPKNTVVFVN QWS-VNHDPA 
Cyp2a4     DLIPMGLARR VTKDT----- ----KFRDFL LPKGTEVFPM LGS-VLKDPK 
Cyp2a5     DMIPMGLARR VTKDT----- ----KFRDFL LPKGTEVFPM LGS-VLKDPK 
Cyp2a12    NFAPLGIPRR ITKNT----- ----SFRGFF LPKATEVFPI LGS-LMTDPK 
Cyp2a22    NFAPLGIPRR ITKDT----- ----SFRGFF LPKGTDVFPI MGS-LMIDPK 
Cyp2b9     DLVPIGLPHK VIKDT----- ----LFRGYL LPKNTEVYPV LSS-ALHDPQ 
Cyp2b10    DLIPIGVPHR VTKDT----- ----MFRGYL LPKNTEVYPI LSS-ALHDPQ 
Cyp2b13    DIVPTGAPHR VTKDT----- ----MFRGYL LPKNTEVYPI LSS-ALHDPQ 
Cyp2b19    DLAPIGLPHK VTKDT----- ----LFRGYL IPKNTEVYPI LSS-ALHDPR 
Cyp2b23    DLAPIGLPHT VTKDT----- ----VFRGYL LPKNTEVYPI LSS-ALHDPQ 
Cyp2c29    DLLPTSLPHA VTCDI----- ----KFRKYL IPKGTTVITS LSS-VLHDSK 
Cyp2c37    DLIPNSLPHE VTCDI----- ----KFRNYF IPKGTTVITS LSS-VLHDST 
Cyp2c38    NLVPNNLPHA VTCDI----- ----KFRNYI IPKGTTVVTS LTS-VLHDSK 
Cyp2c39    NLVPNNIPRA VTCDI----- ----KFRNYL IPKGTTVVTS LTS-VLHDSK 
Cyp2c40    DLGPNGVVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST 
Cyp2c44    TLLPSSLPHA VVQDT----- ----KFRHYV IPKGTAVFPF LSS-ILLDQK 
Cyp2c50    DLVPNSLPHE VTCDI----- ----KFRNYF IPKGTNVITS LSS-VLRDSK 
Cyp2c54    DLVPNNLPHE VTCDI----- ----KFRNYF IPKGTTVITS LSS-VLRDSK 
Cyp2c55    DLIPNNVPHA ATCNV----- ----RFRSYF IPKGTELVTS LTS-VLHDDK 
Cyp2c65    DLLPTSLPHA VTRDV----- ----KFREYL IPKGTTVIAS LTS-VLYDDK 
Cyp2c66    DLLPTSLPHA VTRDV----- ----KFREYL IPKGTTVIAS LTS-VLYDDK 
Cyp2c67    DLGPISLVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST 
Cyp2c68    DLGPNGVVHE VTCDT----- ----KFRNYF IPKGTQVMTS LTS-VLHDST 
Cyp2c69    DLGPTSLVHE VTCDT----- ----KFRNYF IPKGTQVMTS LSS-VLHDST 
Cyp2c70    DFVPIPSPRK TTQDV----- ----EFRGYH IPKGTSVMAC LTS-VLNDDK 
Cyp2ac1    NILPTSLFHE TTTDV----- ----AFKNYY IPKGTEIITL LTS-VLQDQT 
Cyp2ab1    SVVAVGAVRQ CVTST----- ----WMHGYY VPKGTIILPN LAS-VLYDPE 
Cyp2d9     DIVPVNLPRI TSHDI----- ----EVQDFL IPKGTILLPN MSS-MLKDES 
Cyp2d10    DIAPLNLPRI TSRDI----- ----EVQDFL IPKGSILIPN MSS-VLKDET 
Cyp2d34    DIIPLNIPRI TSRDI----- ----EVQDFL IPKGTILIPN MSS-MLKDET 
Cyp2d11    LLHCLCHASQ VVTFT----- ----QVQDFL VTKGSTLIPN LSS-VLKGET 
Cyp2d12    DIVPLHLPRI TSRDI----- ----EVQDFL IPKGTILLPN MSS-VHMDDT 
Cyp2d13    DIVPMNLPHK TSHDI----- ----EVQGFL IPKGTTLIPN LSS-ALKDET 
Cyp2d40    DIAPMTLPHR TSCDI----- ----EVQGFL IPKGTTLICN LSS-VLKDET 
Cyp2d22    DILPLGVPHK TSRDI----- ----ELQGFL IPKGTTLITN LSS-ALKDET 
Cyp2d26    DIVPTNLPHM TSRDI----- ----KFQDFF IPKGTTLIPN LSS-VLKDET 
Cyp2e1     NLVPSNLPHE ATRDT----- ----VFRGYV IPKGTVVIPT LDS-LLFDNY 
Cyp2f2     DVIPMNLPHR VTRDT----- ----PFRGFL IPKGTDVITL LNT-VHYDSD 
Cyp2g1     DIVPLGVPHN VTRDT----- ----HFRGYL LPKGTDVYPL FGS-VLKDPK 
Cyp2j5     NIVPLNSSRE VTVDT----- ----KFNGFH LPKGTMILTN LTA-LHRDPK 
Cyp2j6     NIIPLNVPRE VAMDT----- ----NLNGFH LPKGTMVLTN LTA-LHRDPK 
Cyp2j7     NIVPLNVPRE VTADS----- ----TLAGFH LPKGKMILTN LTA-LHRDPK 
Cyp2j8     NIIPLNVPRE VEADI----- ----TLAGFH LPKGTMVLTN LTA-LHRDPK 
Cyp2j9     NIIPFNVPRE VAVDT----- ----QLAGFN LPKGIMVLSN LTA-LHRDPS 
Cyp2j13    NSVPLNIPRE VAVDT----- ----TLAGFH LPKRSVVMTN LTA-LHMDPK 
Cyp2j12    NILPMNVPRE VTADS----- ----TLAGFH LPKGTMVLTN LTA-LHRDPK 
cyp2j11    NIIPLNVPRE VTADS----- ----TLAGFY LPKGTMVLIN LTD-LHRDPK 
Cyp2r1     NIVPLGIFHA TSEDA----- ----VVRGYS IPKGTTVITN LYS-VHFDEK 
Cyp2s1     ALVPMGMPHT ITRTT----- ----CFRGYT LPKGTEVFPL IGS-ILHDPA 
Cyp2t4     SVLPLGLPRA LTRDV----- ----NLKNHF LHKGTFVIPL LVS-AHRDPT 
Cyp2U1     MVVPLAIPHM TSEKT----- ----VLQGFT IPKGTVVLIN LWS-VHRDPA 
Cyp2w1     TLLP-HVPRC TAADI----- ----QLGGYL LPKGTPVIPL LTS-VLLDKT 
CYP2W1h    TLLP-HVPRC TAADT----- ----QLGGFL LPKGTPVIPL LTS-VLLDET 
Cyp3a11    IANRLERVCK KDVELN---- ------G-VY IPKGSTVMIP SYA-LHHDPQ 
Cyp3a13    IAGRLERVCK TDVEIN---- ------G-LF IPKGTVVMIP TFA-LHKDPK 
Cyp3a16    ITNRLQRVCK KDVEIN---- ------G-IY IPKGSTVIIP SYV-LHHDPQ 
Cyp3a25    IAIRLERVSK KDVEIN---- ------G-VF IPKGTVVMIP IYP-LHRNPE 
Cyp3a59    TAIRLERVSK KDVEIN---- ------G-VF IPKGTVVMIP IYP-LHRNPE 
Cyp3a57    VVSRIDRFSK KDVEIH---- ------G-VF IPKGTIVMIP IYP-LHRDPE 
Cyp3a41    IGNRLERFCK KDVELN---- ------G-VY IPKGSTVMIP SYA-LHHDPQ 
Cyp3a44    IVTRLERVCK KDVELN---- ------G-VY IPKGSMVMIP SYA-LHHDPQ 
Cyp4a10    PVPGIVRELS TSVTFP---- ------DGRS LPKGVQVTLS IYG-LHHNPK 
Cyp4a31    PVPSIGRELS TSVTFP---- ------DGCS LPKGVQVTLS IYG-LHHNPK 
Cyp4a32    PVPGIVRELS TSVTFP---- ------DGRS LPKGVQVTLS IYG-LHHNPK 
Cyp4a12a   PVPSVSRELS SPVTFP---- ------DGRS LPKGIHVMLS FYG-LHHNPT 
Cyp4a12b   PVPSVSRELS SPVTFP---- ------DGRS LPKGIHVMLS FYG-LHHNPT 
Cyp4a14    PVISVSRELS SPVTFP---- ------DGRS IPKGITATIS IYG-LHHNPR 
Cyp4a30b   PIPGASRELS SPVTFP---- ------DGCS LPKGFLVTLS FYG-LHHNPR 
Cyp4a29    PIPSVGRKLS TPVTFP---- ------DGRS LPKGIESTVS CFI-FFSAWK 
Cyp4b1     PVPQVYRQLS KPVTFV---- ------DGRS LPAGSLISLH IYA-LHRNSA 
Cyp4f13    PVLLISRCCT QDVLLP---- ------DGRA IPKGNICVIS IFG-VHHNPS 
Cyp4f14    PVTVISRCCT QDILLP---- ------DGRT IPKGIICLIS IFG-IHHNPS 
Cyp4f15    PVTVISRRCT QDIVLP---- ------DGRV IPKGVICIIN IFA-THHNPT 
Cyp4f16    PVIDLLRRCT RDIVLP---- ------DGRV IPKGNICVIS IFG-IHHNPS 
Cyp4f17    PVTVISRCCT QDVVLP---- ------DGRV IPKGTDCVIS IFG-VHHNPE 
Cyp4f18    PVTAISRCCT QDIVLP---- ------DGRV IPKGVISRIS IFG-THHNPA 
Cyp4f37    PVIDLLRRCT RDIVLP---- ------DGRV IPKGNICVIS IFG-IHHNPS 
Cyp4f39    PVTLISRRCT EDIKLP---- ------DGRV IPKGIICLVS IYG-THHNPI 
Cyp4f40    PVTMVSRCCT QDISLP---- ------DGRI IPKGVICIIN IFG-THHNPT 
Cyp4v3     SVPLFARSLS EDCEVG---- ------G-YK VTKGTEAIII PYA-LHRDPR 
Cyp4x1     PVPSISRELS KPLTLP---- ------DGHS LPAGMTVVLS IWG-LHHNPA 
Cyp5a1     PAFRFTREAA QDCEVL---- ------G-QR IPAGTVLEIA VGA-LHHDPE 
Cyp7a1     ASLNIRTAKE DFTLHLED-- ------GSYN IRKDDIIALY PQL-MHLDPE 
Cyp7b1     YSSIIREVQE DMNLSLES-- ------KSFS LRKGDFVALF PPL-IHNDPE 
Cyp8a1     APFITREVMA DLALPMAD-- -----GREFS LRRGDRLLLF PFLSPQKDPE 
Cyp8b1     TPTLLRVVQE DYVLKMAS-- -----GQEYQ IRRGDKVALF PYLSVHMDPD 
Cyp11a1    PISVTLQ-RY TVNDL----- ----VLRNYK IPAKTLVQVA SFA-MGRDPG 
Cyp11b1    PVGTFLE-RI LSSDL----- ----VLQNYH VPAGTVLNVN LYS-MGRNPA 
Cyp11b2    PVGGFLE-RI LSSDL----- ----VLQNYH VPAGTLVLLY LYS-MGRNPA 
Cyp17      PVAPLLIPHK ANIDS----- ----SIGEFA IPKDTHVIIN LWA-LHHDKN 
Cyp19      PVVDLVMRRA LEDDV----- -----IDGYP VKKGTNIILN IGR-MHRLEY 
Cyp20      LTPVSARLQD IEGKVG---- ------P-FV IPKETLVLYA LGV-VLQDPS 
Cyp21      PVVPLALPHR ATRAS----- ----SISGYD IPKDMVIIPN IQG-ANLDEM 
Cyp24      PSVPFTT-RT LDKPT----- ----VLGEYT LPKGTVLTLN TQV-LGSSED 
Cyp26a1    PVPGGFRVAL KTFELNG--- --------YQ IPKGWNVIYS ICDTHDVADI 
Cyp26b1    PVSGGYRTVL QTFELDG--- --------FQ IPKGWSVMYS IRDTHDTAPV 
Cyp26c1    PVSGGYRTAL RTFELDG--- --------YQ IPKGWSVMYS IRDTHETAAV 
Cyp27a1    PVVPTNSRII TEKET----- ----EINGFL FPKNTQFVLC HYV-VSRDPS 
Cyp27b1    PVVPGNS-RV PDRDI----- ----RVGNYV IPQDTLVSLC HYA-TSRDPT 
Cyp39      PGVITRKVVK PVKILN---- --------HT VPSGDLLMLS PFW-LHRNPK 
Cyp46      PAWGTFRLLE EETLID---- ------G-VR VPGNTPLLFS TYV-MGRMDT 
Cyp51      PIMTMMRMAK TPQTVAG--- --------YT IPPGHQVCVS PTV-NQRLKD 
CYP1A1h    SFVPFTIPHS TTRDT----- ----SLKGFY IPKGRCVFVN QWQ-INHDQK 
CYP1A2h    SFLPFTIPHS TTRDT----- ----TLNGFY IPKKCCVFVN QWQ-VNHDPE 
CYP1B1h    SFVPVTIPHA TTANT----- ----SVLGYH IPKDTVVFVN QWS-VNHDPV 
CYP2A6     DVIPMSLARR VKKDT----- ----KFRDFF LPKGTEVYPM LGS-VLRDPS 
CYP2A7     DVIPMSLARR VKKDT----- ----KFRDFF LPKGTEVFPM LGS-VLRDLR 
CYP2A13    DMLPMGLAHR VNKDT----- ----KFRDFF LPKGTEVFPM LGS-ELRDPR 
CYP2B6     DLLPMGVPHI VTQHT----- ----SFRGYI IPKDTEVFLI LST-ALHDPH 
CYP2C8     DLVPTGVPHA VTTDT----- ----KFRNYL IPKGTTIMAL LTS-VLHDDK 
CYP2C9     DLLPTSLPHA VTCDI----- ----KFRNYL IPKGTTILIS LTS-VLHDNK 
CYP2C18    DLLPTNLPHA VTCDV----- ----KFKNYL IPKGTTIITS LTS-VLHNDK 
CYP2C19    DLIPTSLPHA VTCDV----- ----KFRNYL IPKGTTILTS LTS-VLHDNK 
CYP2D6     DIVPLGMTHM TSRDI----- ----EVQGFR IPKGTTLITN LSS-VLKDEA 
CYP2E1h    TLVPSNLPHE ATRDT----- ----IFRGYL IPKGTVVVPT LDS-VLYDNQ 
CYP2F1     DIIPMNLPHR VTRDT----- ----AFRGFL IPKGTDVITL LNT-VHYDPS 
CYP2G2P    DIVPMGVPHN LIRDT----- ----QFRGYL LPKGTDVFPL LGS-VLKDPK 
CYP2J2     NIIPQNVPRE VTVDT----- ----TLAGYH LPKGTMILTN LTA-LHRDPT 
CYP2R1h    NIVPLGIFHA TSEDA----- ----VVRGYS IPKGTTVITN LYS-VHFDEK 
CYP2S1h    ALVPMGIPRT LMRTT----- ----RFRGYT LPQGTEVFPL LGS-ILHEPN 
CYP2T2P    SVVPLGLPRT LTLDT----- ----HLHSHC LPKGTFVIPL LVT-AHRDPT 
CYP2U1h    VVVPLAIPHM TSENT----- ----VLQGYT IPKGTLILPN LWS-VHRDPA 
CYP3A4     IAMRLERVCK KDVEIN---- ------G-MF IPKGWVVMIP SYA-LHRDPK 
CYP3A5     VAIRLERTCK KDVEIN---- ------G-VF IPKGSMVVIP TYA-LHHDPK 
CYP3A7     VAMRLERVCK KDVEIN---- ------G-MF IPKGVVVMIP SYV-LHHDPK 
CYP3A43    VVSRVTRVCK KDIEIN---- ------G-VF IPKGLAVMVP IYA-LHHDPK 
CYP4A11    PVPGIGRELS TPVTFP---- ------DGRS LPKGIMVLLS IYG-LHHNPK 
CYP4A22    PVPGIGRELS TPVTFP---- ------DGRS LPKGIMVLLS IYG-LHHNPK 
CYP4B1h    PVPQVYRQLS KPVTFV---- ------DGRS LPAGSLISMH IYA-LHRNSA 
CYP4F2     PVPVISRHVT QDIVLP---- ------DGRV IPKGIICLIS VFG-THHNPA 
CYP4F3     PVPAVSRCCT QDIVLP---- ------DGRV IPKGIICLIS VFG-THHNPA 
CYP4F8     PIPTFARGCT QDVVLP---- ------DSRV IPKGNVCNIN IFA-IHHNPS 
CYP4F11    PVPVISRCCT QDFVLP---- ------DGRV IPKGIVCLIN IIG-IHYNPT 
CYP4F12    PAPFISRCCT QDIVLP---- ------DGRV IPKGITCLID IIG-VHHNPT 
CYP4F22    PVTLVSRQCT EDIKLP---- ------DGRI IPKGIICLVS IYG-THHNPT 
CYP4F23P   PVSRIHRCCP QDGVLP---- ------DGRV IPKGNTCTIS IFG-IHHNPS 
CYP4V2     SVPLFARSVS EDYFLT---- ------AGYR VLKGTEAVII PYA-LHRDPR 
CYP4X1h    AVPSISRDLS KPLTFP---- ------DGCT LPAGITVVLS IWG-LHHNPA 
CYP4Z1     PVVNISRLLD KPITFP---- ------DGRS LPAGITVFIN IWA-LHHNPY 
CYP5A1h    PAFRFTREAA QDCEVL---- ------G-QR IPAGAVLEMA VGA-LHHDPE 
CYP7A1h    ASLNIRTAKE DFTLHLED-- -----G-SYN IRKDSIIALY PQL-MHLDPE 
CYP7B1h    YSTTIRFVEE DLTLSSET-- -----G-DYC VRKGDLVAIF PPV-LHGDPE 
CYP8A1h    APFITREVVV DLAMPMAD-- -----GREFN LRRGDRLLLF PFLSPQRDPE 
CYP8B1h    APTLLRLVHE DYTLKMSS-- -----GQEYL FRHGDILALF PYLSVHMDPD 
CYP11A1h   PISVTLQ-RY LVNDL----- ----VLRDYM IPAKTLVQVA IYA-LGREPT 
CYP11B1h   PVGLFLE-RV ASSDL----- ----VLQNYH IPAGTLVRVF LYS-LGRNPA 
CYP11B2h   PVGLFLE-RV VSSDL----- ----VLQNYH IPAGTLVQVF LYS-LGRNAA 
CYP17h     PVAPMLIPHK ANVDS----- ----SIGEFA VDKGTEVIIN LWA-LHHNEK 
CYP19h     PVVDLVMRKA LEDDV----- -----IDGYP VKKGTNIILN IGR-MHRLEF 
CYP20h     LTPVSAQLQD IEGKID---- ------R-FI IPRETLVLYA LGV-VLQDPN 
CYP21A2h   PVVPLALPHR TTRPS----- ----SISGYD IPEGTVIIPN LQG-AHLDET 
CYP24h     PGVPFTT-RT LDKAT----- ----VLGEYA LPKGTVLMLN TQV-LGSSED 
CYP26A1h   PVPGGFRVAL KTFELNG--- --------YQ IPKGWNVIYS ICDTHDVAEI 
CYP26B1h   PISGGYRTVL QTFELDG--- --------FQ IPKGWSVMYS IRDTHDTAPV 
CYP26C1h   PVSGGYRTAL RTFELDG--- --------YQ IPKGWSVMYS IRDTHETAAV 
CYP27A1h   PVVPTNS-RI IEKEI----- ----EVDGFL FPKNTQFVFC HYV-VSRDPT 
CYP27B1h   PVVPGNS-RV PDKDI----- ----HVGDYI IPKNTLVTLC HYA-TSRDPA 
CYP27C1h   PVLPGNG-RV TQEDL----- ----VIGGYL IPKGTQLALC HYA-TSYQDE 
CYP39A1h   PGVITRKVVK PVEILN---- --------YI IPSGDLLMLS PFW-LHRNPK 
CYP46h     PAWGTFRLLE EETLID---- ------G-VR VPGNTPLLFS TYV-MGRMDT 
CYP51h     PIMIMMRMAR TPQTVAG--- --------YT IPPGHQVCVS PTV-NQRLKD 

Cyp1a1     LWGDPNEFRP ERFLTPSG-- -TLDKR---- LSEKVTLFGL G--KRKCIGE 
Cyp1a2     QWKDPFVFRP ERFLTNNNS- -AIDKT---- QSEKVMLFGL G--KRRCIGE 
Cyp1b1     KWPNPEDFDP ARFLDKDG-- -FINKA---- LASSVMIFSV G--KRRCIGE 
Cyp2a4     FFSNPKDFNP KHFLDDKG-- ---QFK---- KSDAFVPFSI G--KRYCFGE 
Cyp2a5     FFSNPKDFNP KHFLDDKG-- ---QFK---- KNDAFVPFSI G--KRYCFGE 
Cyp2a12    FFSSPKDFNP QHFLDDKG-- ---QLK---- KIPAFLPFST G--KRFCLGD 
Cyp2a22    FFSSPKDFNP QHFLDDKG-- ---QLK---- KIPAFLPFSI G--KRSCLGY 
Cyp2b9     YFEQPDKFNP EHFLDANG-- ---ALK---- KCEAFLPFST G--KRICLGE 
Cyp2b10    YFEQPDSFNP DHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE 
Cyp2b13    YFEQPDSFNP DHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE 
Cyp2b19    YFEQPDSFNP EHFLDANG-- ---ALK---- TNEAFMPFST G--KRICLGE 
Cyp2b23    YFEQPDKFNP EHFLDANG-- ---ALK---- KSEAFLPFST G--KRICLGE 
Cyp2c29    EFPNPEMFDP GHFLNGNG-- ---NFK---- KSDYFMPFST G--KRICAGE 
Cyp2c37    EFPNPEVFDP GHFLDGNG-- ---KFK---- KSDYFMPFST G--KRICAGE 
Cyp2c38    EFPNPEMFDP GHFLDANG-- ---NFK---- KSDYFMTFSA G--KRVCAGE 
Cyp2c39    EFPNPELFDP GHFLDANG-- ---NFK---- KSDHFMPFSA G--KRVCAGE 
Cyp2c40    EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFMPFSA G--KRICVGE 
Cyp2c44    EFPNPEKFDP GHFLDKNG-- ---CFK---- KTDYFVPFSL G--KRSCVGE 
Cyp2c50    EFPNPEKFDP GHFLDENG-- ---KFK---- KSDYFMPFST G--KRICAGE 
Cyp2c54    EFPNPEKFDP GHFLDENG-- ---KFK---- KSDYFMPFST G--KRICAGE 
Cyp2c55    EFPNPEVFDP GHFLDENG-- ---NFK---- KSDYFMPFSI G--KRMCVGE 
Cyp2c65    EFPNPEKFDP SHFLDERG-- ---KFK---- KSDYFFPFST G--KRICVGE 
Cyp2c66    EFLNPERFDP SHFLDESG-- ---KFK---- KSDYFFPFST G--KRICVGE 
Cyp2c67    EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA G--KRICVGE 
Cyp2c68    EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA ---------- 
Cyp2c69    EFPNPEVFDP GHFLDDNG-- ---NFK---- KSDYFVPFSA G--KRICVGE 
Cyp2c70    EFPNPEKFDP GHFLDEKG-- ---NFK---- KSDYFVAFSA G--RRACIGE 
Cyp2ac1    QWEASDAFDP AHFLSPKG-- ---TFV---- KKESFVPFSW G--CHMCAGE 
Cyp2ab1    CWESPHQFNP GHFLDKDG-- ---NFV---- ANEAFLPFSA G--HRVCPGE 
Cyp2d9     VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d10    VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d34    VWEKPLRFYP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d11    VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--HRSCLGE 
Cyp2d12    VWEKPLRFHP EHFLDAQG-- ---HFV---- KHEAFITFSA G--RRSCLGE 
Cyp2d13    VWEKPLRFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRACLGE 
Cyp2d40    VWEKPLRFYP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRACLGE 
Cyp2d22    VWEKPLCFHP EHFLDAQG-- ---HFV---- KPEAFMPFSA G--RRSCLGE 
Cyp2d26    VWEKPLRFYP EHFLDAQG-- ---HFV---- KHEAFMPFSA G--RRSCLGE 
Cyp2e1     EFPDPETFKP EHFLNENG-- ---KFK---- YSDYFKAFSA G--KRVCVGE 
Cyp2f2     QFKTPQEFNP EHFLDDNH-- ---SFK---- KSPAFMPFSA G--RRLCLGE 
Cyp2g1     YFRYPDAFYP QHFLDEQG-- ---RFK---- KNDAFVVFSS G--KRICVGE 
Cyp2j5     EWATPEVFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j6     EWATPDVFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j7     EWATPDIFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACPGE 
Cyp2j8     EWATPDVFNP EHFLE-NG-- ---QFK---- KRESFLPFSV G--KRGCPGE 
Cyp2j9     EWTTPDTFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j13    EWATPDIFNP EHFLE-NG-- ---QFK---- KRESFLPFSM G--KRACLGE 
Cyp2j12    EWATPNTFNP EHFLE-NG-- ---QFK---- KRESFLPFSL G--KRACPGE 
cyp2j11    EWDTPNVFNP EHFLE-NG-- ---QFK---- KKESFLPFSM G--KRACPGE 
Cyp2r1     YWKDPDMFYP ERFLDSNG-- ---YFT---- KKEALIPFSL G--RRHCLGE 
Cyp2s1     VFQNPGEFHP GRFLDEDG-- ---RLR---- KHEAFLPYSL G--KRVCLGE 
Cyp2t4     QFKDPDHFNP TNFLDDHG-- ---EFQ---- NNDAFMPFAL G--KRMCLGA 
Cyp2U1     IWEKPDDFCP HRFLDDQG-- ---QLL---- KRETFIPFGI G--------- 
Cyp2w1     QWETPSQFNP NHFLDAKG-- ---RFM---- KRGAFLPFSA G--RRVCVGK 
CYP2W1h    QWQTPGQFNP GHFLDANG-- ---HFV---- KREAFLPFSA G--RRVCVGE 
Cyp3a11    HWSEPEEFQP ERFSKENK-- -------GSI DPYVYLPFGN G--PRNCLGM 
Cyp3a13    YWPEPEEFRP ERFSKKNQ-- -------DSI NPYMYLPFGS G--PRNCIGM 
Cyp3a16    HWPEPEEFQP ERFSKENK-- -------GSI DPYVYLPFGN G--PRNCIGM 
Cyp3a25    YWPEPQEFCP ERFSKENK-- -------GNI DPYIYMPFGN G--PRNCIGM 
Cyp3a59    YWPEPQEFCP GRFSKENE-- -------GNI DPYIYMPFGN G--PRNCLDM 
Cyp3a57    YWPEPEDFCP ERFSKENK-- -------GNI DPYIYMPFGN G--PRNCIGM 
Cyp3a41    HWPEPEEFQP ERFSKENK-- -------GSI DPYLYMPFGI G--PRNCIGM 
Cyp3a44    HWPDPEEFQP ERFSKENK-- -------GSI DPYVYLPFGI G--PRNCIGM 
Cyp4a10    VWPNPEVFDP SRFAPD---- -------SPR HSHSFLPFSG G--ARNCIGK 
Cyp4a31    VWPNPEVFDP SRFAPD---- -------SPR HSHSFLPFSG G--ARNCIGK 
Cyp4a32    VWPNPEVFDP SRFAPD---- -------SPR HSHSFLPFSG G--ARNCIGK 
Cyp4a12a   VWPNPEVFDP SRFAPG---- -------SSR HSHSFLPFSG G--ARNCIGK 
Cyp4a12b   VWPNPEVFDP SRFAPG---- -------SSR HSHSFLPFSG G--ARNCIGK 
Cyp4a14    FWPNPKVFDP SRFAPD---- -------SSH HSHAYLPFSG G--SRNCIGK 
Cyp4a30b   LRPNAEVFDP SRFAPG---- -------APR QTHAFLPFSA G--TRNCIGK 
Cyp4a29    AFDKPEVFDP SRFAMN---- -------SVQ HSHAFLPFSG G--SRNCIGK 
Cyp4b1     VWPDPEVFDP LRFSPENM-- -------TGR HPFAFMPFSA G--PRNCIGQ 
Cyp4f13    VWPDPEVYNP FRFDPENP-- -------QKR SPLAFIPFSA G--TRNCIGQ 
Cyp4f14    VWPDPEVYDP FRFDPENI-- -------KDS SPLAFIPFSA G--PRNCIGQ 
Cyp4f15    VWPDPEVYDP FRFDPENI-- -------KDR SPLAFIPFSA G--PRNCIGQ 
Cyp4f16    VWPDPEVYDP FRFDPENP-- -------QKR SPLAFIPFSA G--PRNCIGQ 
Cyp4f17    VWPDPEVYDP FRFDPENP-- -------QKR SPLAFIPFSA G--PRNCIGQ 
Cyp4f18    VWPDPEVYDP FRFDADNV-- -------KGR SPLAFIPFSA G--PRNCIGQ 
Cyp4f37    VWPDPEVYDP FRFDPENA-- -------HKR PPLAFIPFSA G--PRNCIGQ 
Cyp4f39    VWPDSKVYNP YRFDPDTP-- -------QQR SPLAFVPFSA G--PRNCIGQ 
Cyp4f40    VWRDPEVYDP FRFDPENI-- -------QAR SPLSFIPFSA G--PRNCIGQ 
Cyp4v3     YFPDPEEFRP ERFFPENS-- -------QGR HPYAYVPFSA G--PRNCIGQ 
Cyp4x1     VWNDPKVFDP LRFTKENS-- -------DQR HPCAFLPFSS G--PRNCIGQ 
Cyp5a1     HWPNPETFDP ERFTAEAR-- -------LQR RPFTYLPFGA G--PRSCLGV 
Cyp7a1     IYPDPLTFKY DRYLDESGKA KTTFYRNGNK LKYFYMPFGS G--ATICPGR 
Cyp7b1     IFDAPKEFRF DRFIED-GKK KSTFFKGGKR LKTYVMPFGL G--TSKCPGR 
Cyp8a1     IYTEPEVFKY NRFLNPDGSE KKDFYKDGKR LKNYNMPWGA G--HNQCLGK 
Cyp8b1     IHPEPTAFKY DRFLNPDGTR KVDFYKSGKK IHHYSMPWGS G--VSKCPGR 
Cyp11a1    FFPNPNKFDP TRWLEKSQ-- ---NT----- THFRYLGFGW G--VRQCLGR 
Cyp11b1    VFPRPERYMP QRWLERK--- ---------- RSFKHLAFGF G--VRQCLGR 
Cyp11b2    VFPRPERYMP QRWLERK--- ---------- RSFQHLAFGF G--VRQCLGR 
Cyp17      EWDQPDRFMP ERFLDPTG-- -SHLIT---- PTPSYLPFGA G--PRSCIGE 
Cyp19      -FPKPNEFTL ENFEKNVP-- ---------- -YRYFQPFGF G--PRGCAGK 
Cyp20      TWPLPHRFDP DRFADE---- -------PVM KVFSSLGFSG ---TWECPEL 
Cyp21      VWELPSKFWP DRFLEPG--- ---------- KNPRTPSFGC G--ARVCLGE 
Cyp24      NFEDADKFRP ERWLEKEK-- ---KIN---- -PFAHLPFGV G--KRMCIGR 
Cyp26a1    FTNKE-EFNP DRFIVPHPE- -----DAS-- -RFSFIPFGG G--LRSCVGK 
Cyp26b1    FKDVN-VFDP DRFSQARSE- -----DK--D GRFHYLPFGG G--VRTCLGK 
Cyp26c1    YRSPPEGFDP ERFGVESGD- -----ARGSG GRFHYIPFGG G--ARSCLGQ 
Cyp27a1    VFPEPNSFQP HRWLRKKE-- ---ADNPGIL HPFGSVPFGY G--VRSCLGR 
Cyp27b1    QFPDPNSFNP ARWLGEGP-- ---TP----- HPFASLPFGF G--KRSCIGR 
Cyp39      YFPEPESFKP ERWKEAN--- -----LDKYI FLDYFMAFGG G--KFQCPGR 
Cyp46      YFEDPLTFNP DRFGPG---- -------APK PRFTYFPFSL G--HRSCIGQ 
Cyp51      SWAERLDFNP DRYLQDN--- -----PAS-G EKFAYVPFGA G--RHRCVGE 
CYP1A1h    LWVNPSEFLP ERFLTPDG-- -AIDKV---- LSEKVIIFGM G--KRKCIGE 
CYP1A2h    LWEDPSEFRP ERFLTADGT- -AINKP---- LSEKMMLFGM G--KRRCIGE 
CYP1B1h    KWPNPENFDP ARFLDKDG-- -LINKD---- LTSRVMIFSV G--KRRCIGE 
CYP2A6     FFSNPQDFNP QHFLNEKG-- ---QFK---- KSDAFVPFSI G--KRNCFGE 
CYP2A7     FFSNPRDFNP QHFLGEKG-- ---QFK---- KRDAFVPFSI R--KRNCFGE 
CYP2A13    FFSNPQDCSP QHFLDEKG-- ---QFK---- KSDAFVPFSI G--KRYCFGE 
CYP2B6     YFEKPDAFNP DHFLDANG-- ---ALK---- KTEAFIPFSL G--KRICLGE 
CYP2C8     EFPNPNIFDP GHFLDKNG-- ---NFK---- KSDYFMPFSA G--KRICAGE 
CYP2C9     EFPNPEMFDP HHFLDEGG-- ---NFK---- KSKYFMPFSA G--KRICVGE 
CYP2C18    EFPNPEMFDP GHFLDKSG-- ---NFK---- KSDYFMPFSA G--KRMCMGE 
CYP2C19    EFPNPEMFDP RHFLDEGG-- ---NFK---- KSNYFMPFSA G--KRICVGE 
CYP2D6     VWEKPFRFHP EHFLDAQG-- ---HFV---- KPEAFLPFSA G--RRACLGE 
CYP2E1h    EFPDPEKFKP EHFLNENG-- ---KFK---- YSDYFKPFST G--KRVCAGE 
CYP2F1     QFLTPQEFNP EHFLDANQ-- ---SFK---- KSPAFMPFSA G--RRLCLGE 
CYP2G2P    YFRYPDAFYP QHFLDEQG-- ---RFK---- KNEAFVPFSS GRGKRICLGE 
CYP2J2     EWATPDTFNP DHFLE-NG-- ---QFK---- KREAFMPFSI G--KRACLGE 
CYP2R1h    YWRDPEVFHP ERFLDSSG-- ---YFA---- KKEALVPFSL G--RRHCLGE 
CYP2S1h    IFKHPEEFNP DRFLDADG-- ---RFR---- KHEAFLPFSL G--KRVCLGE 
CYP2T2P    QFKDPDCFNP TNFLDKG--- ---KFQ---- GNDAFMPFAP A--KQMCLGT 
CYP2U1h    IWEKPEDFYP NRFLDDQG-- ---QLI---- KKETFIPFGI G--KRVCMGE 
CYP3A4     YWTEPEKFLP ERFSKKNK-- -------DNI DPYTYTPFGS G--PRNCIGM 
CYP3A5     YWTEPEEFRP ERFSKK-K-- -------DSI DPYIYTPFGT G--PRNCIGM 
CYP3A7     YWTEPEKFLP ERFSKKNK-- -------DNI DPYIYTPFGS G--PRNCIGM 
CYP3A43    YWTEPEKFCP ERFSKKNK-- -------DSI DLYRYIPFGA G--PRNCIGM 
CYP4A11    VWPNPEVFDP SRFAPG---- -------SAQ HSHAFLPFSG G--SRNCIGK 
CYP4A22    VWPNLEVFDP SRFAPG---- -------SAQ HSHAFLPFSG G--SRNCIGK 
CYP4B1h    VWPDPEVFDS LRFSTENA-- -------SKR HPFAFMPFSA G--PRNCIGQ 
CYP4F2     VWPDPEVYDP FRFDPENI-- -------KER SPLAFIPFSA G--PRNCIGQ 
CYP4F3     VWPDPEVYDP FRFDPKNI-- -------KER SPLAFIPFSA G--PRNCIGQ 
CYP4F8     VWPDPEVYDP FRFDPENA-- -------QKR SPMAFIPFSA G--PRNCIGQ 
CYP4F11    VWPDPEVYDP FRFNQENI-- -------KER SPLAFIPFSA G--PRNCIGQ 
CYP4F12    VWPDPEVYDP FRFDPENS-- -------KGR SPLAFIPFSA G--PRNCIGQ 
CYP4F22    VWPDSKVYNP YRFDPDNP-- -------QQR SPLAYVPFSA G--PRNCIGQ 
CYP4F23P   VWPDPEVYDP FRFDPENL-- -------QKT SPLAFIPFSA V--PRNCIGQ 
CYP4V2     YFPNPEEFQP ERFFPENA-- -------QGR HPYAYVPFSA G--PRNCIGQ 
CYP4X1h    VWKNPKVFDP LRFSQENS-- -------DQR HPYAYLPFSA G--SRNCIGQ 
CYP4Z1     FWEDPQVFNP LRFSRENS-- -------EKI HPYAFIPFSA G--PRNCIGQ 
CYP5A1h    HWPSPETFNP ERFTAEAR-- -------QQH RPFTYLPFGA G--PRSCLGV 
CYP7A1h    IYPDPLTFKY DRYLDENGKT KTTFYCNGLK LKYYYMPFGS G--ATICPGR 
CYP7B1h    IFEAPEEFRY DRFIED-GKK KTTFFKRGKK LKCYLMPFGT G--TSKCPGR 
CYP8A1h    IYTDPEVFKY NRFLNPDGSE KKDFYKDGKR LKNYNMPWGA G--HNHCLGR 
CYP8B1h    IHPEPTVFKY DRFLNPNGSR KVDFFKTGKK IHHYTMPWGS G--VSICPGR 
CYP11A1h   FFFDPENFDP TRWLSKDK-- ---NI----- TYFRNLGFGW G--VRQCLGR 
CYP11B1h   LFPRPERYNP QRWLDIRG-- ---SG----- RNFYHVPFGF G--MRQCLGR 
CYP11B2h   LFPRPERYNP QRWLDIRG-- ---SG----- RNFHHVPFGF G--MRQCLGR 
CYP17h     EWHQPDQFMP ERFLNPAG-- -TQLIS---- PSVSYLPFGA G--PRSCIGE 
CYP19h     -FPKPNEFTL ENFAKNVP-- ---------- -YRYFQPFGF G--PRGCAGK 
CYP20h     TWPSPHKFDP DRFDDE---- -------LVM KTFSSLGFSG ---TQECPEL 
CYP21A2h   VWERPHEFWP DRFLEPG--- ---------- KNSRALAFGC G--ARVCLGE 
CYP24h     NFEDSSQFRP ERWLQEKE-- ---KIN---- -PFAHLPFGV G--KRMCIGR 
CYP26A1h   FTNKE-EFNP DRFMLPHPE- -----DAS-- -RFSFIPFGG G--LRSCVGK 
CYP26B1h   FKDVN-VFDP DRFSQARSE- -----DK--D GRFHYLPFGG G--VRTCLGK 
CYP26C1h   YRSPPEGFDP ERFGAARED- -----SRGAS SRLHYIPFGG G--ARSCLGQ 
CYP27A1h   AFSEPESFQP HRWLRNSQ-- ---PATPRIQ HPFGSVPFGY G--VRACLGR 
CYP27B1h   QFPEPNSFRP ARWLGEGP-- ---TP----- HPFASLPFGF G--KRSCMGR 
CYP27C1h   NFPRAKEFRP ERWLRKGD-- ---LDR---V DNFGSIPFGH G--VRSCIGR 
CYP39A1h   YFPEPELFKP ERWKKAN--- -----LEKHS FLDCFMAFGS G--KFQCPAR 
CYP46h     YFEDPLTFNP DRFGPG---- -------APK PRFTYFPFSL G--HRSCIGQ 
CYP51h     SWVERLDFNP DRYLQDN--- -----PAS-G EKFAYVPFGA G--RHRCIGE 

Cyp1a1     TIGRSEVFLF LAILLQQIEF KVSPG----E KVDMT----- ---------- 
Cyp1a2     IPAKWEVFLF LAILLQHLEF SVPPG----V KVDLT----- ---------- 
Cyp1b1     ELSKMLLFLF ISILAHQCNF KANQN----E SSNMS----- ---------- 
Cyp2a4     GLARMELFLF LTNIMQNFHF KSTQA---PQ DIDVS----- ---------- 
Cyp2a5     GLARMELFLF LTNIMQNFHF KSTQA---PQ DIDVS----- ---------- 
Cyp2a12    SLAKMELFFL FTTILQNFRF KFPRK---LE DINES----- ---------- 
Cyp2a22    SLGKMQLFLF FTTILQNFRF KFPRK---LE DINES----- ---------- 
Cyp2b9     SIARNELFIF FTTILQNFSV ASPVA---PK DIDLT----- ---------- 
Cyp2b10    SIARNELFLF FTSILQNFSV ASHVA---PK DIDLT----- ---------- 
Cyp2b13    SIARNELFLF FTSILQNFSV ASPVA---SK DIDLT----- ---------- 
Cyp2b19    GIARNELFLF FTTILQNFSL ASPVA---PE NIDLI----- ---------- 
Cyp2b23    GIARNELFLF FTALLQNFSL SSPVA---PE DIDLT----- ---------- 
Cyp2c29    GLARMELFLI LTTILQNFKL KSLVH---PK EIDIT----- ---------- 
Cyp2c37    GLARMELFLF LTSILQSFNL KPLVH---PK DIDVT----- ---------- 
Cyp2c38    GLARMELFLI LTTILQNFKL KSLVH---PK DIDMM----- ---------- 
Cyp2c39    GLARMELFLF LTTILQNFKL KPLVH---PK DIDMI----- ---------- 
Cyp2c40    SLARMELFLF LTTILQNFKL KPLVD---PK DIDMT----- ---------- 
Cyp2c44    GLARMELFLF FTTILQKFSL KALVE---PK DLDIK----- ---------- 
Cyp2c50    GLARMELFLF LTSILQNFNL KPLVH---PK DIDVT----- ---------- 
Cyp2c54    GLARMELFLF LTSILQNFNL KPLVH---PK DIDIT----- ---------- 
Cyp2c55    ALARTELFLI LTTILQNFNL KSLVD---TK DIDTT----- ---------- 
Cyp2c65    GLARAELFLF LTTILQNFNL KSPVD---LK DLDTT----- ---------- 
Cyp2c66    GLARTELFLF LTTILQNFNL KSPVD---LK DLDTT----- ---------- 
Cyp2c67    SLARMELFLF LTTILQNFKL KPLVD---PK DIDMT----- ---------- 
Cyp2c68    ---------- ---------- ---------- ---------- ---------- 
Cyp2c69    SLARMELFLF LTTILQNFKL KPLVD---PK DIDTT----- ---------- 
Cyp2c70    GLARMEMFLI LTNILQHFTL KPLVK---PE DIDTK----- ---------- 
Cyp2ac1    PLAKMELFLF FTSLMQKFIF QSPVS---HL DLDLT----- ---------- 
Cyp2ab1    QLARMELFLM FATLLRTFQF QLPEG---SQ DLGLE----- ---------- 
Cyp2d9     ALARMELFLF FTCLLQRFSF SVPDG---QP QPSNS----- ---------- 
Cyp2d10    PLARMELFLF FTCLLQHFSF SVPNG---QP RPRNL----- ---------- 
Cyp2d34    PLARMELFLF FTCLLQRFSF SVPAG---QP QPSDH----- ---------- 
Cyp2d11    ALARMELFLF FTCLLQRFSI SVPDG---QP QPSNY----- ---------- 
Cyp2d12    PLARMELFLF FTCLLQRFSF SVPDG---QP QPSDH----- ---------- 
Cyp2d13    PLARMELFLF FTCLLQRFSF LVPAG---QP QPSDY----- ---------- 
Cyp2d40    PLVRMELFLF FTCLLQRFSF SVPDG---QP LPSDY----- ---------- 
Cyp2d22    PLARMELFLF FTCLLQRFSI SVPDG---QP QPSDH----- ---------- 
Cyp2d26    PLARMELFLF FTCLLQRFSF SVPDG---QP RPSDY----- ---------- 
Cyp2e1     GLARMELFLL LSAILQHFNL KSLVD---PK DIDLS----- ---------- 
Cyp2f2     PLARMELFIY FTSILQNFTL QPLVD---PE DIDLT----- ---------- 
Cyp2g1     ALARMELFLY FTSILQRFSL RSLVP---PA DIDIA----- ---------- 
Cyp2j5     QLAKSELFIF FSALMQKFTF KPPIN----E KLSLK----- ---------- 
Cyp2j6     QLARSELFIF FTSLMQKFTF NPPIN----E KLSPK----- ---------- 
Cyp2j7     QLARTELFIF FTALMQKFTF KAPVN----E KLSLK----- ---------- 
Cyp2j8     QLARSELFTF FTALMQKFTF KPPIN----E KLSLN----- ---------- 
Cyp2j9     QLARSELFIF ITTLFQKFTF KPPVN----E KLSLQ----- ---------- 
Cyp2j13    QLARSELFIF FTALVQKFTF KPPAN----E NLSLK----- ---------- 
Cyp2j12    QLARSELFIF FTALMQKFTF KPPIN----E KLSLK----- ---------- 
cyp2j11    QLASCELFIF FTALMQKFTF KSPIN----E KPSLK----- ---------- 
Cyp2r1     QLARMEMFLF FTSLLQQFHL HFPHE----L VPNLK----- ---------- 
Cyp2s1     GLARAELWLF FTSILQAFSL ETPCP---PG DLSLK----- ---------- 
Cyp2t4     GLARSEIFLF LTAILQKFSL LPVGS---PA NINLN----- ---------- 
Cyp2U1     ---------- ---------- ---------- ---------- ---------- 
Cyp2w1     SLARTELFLL FAGLLQRYRL LPPPG---LS PADLDLR--- ---------- 
CYP2W1h    RLARTELFLL FAGLLQRYRL LPPPG---VS PASLDTT--- ---------- 
Cyp3a11    RFALMNMKLA LTKIMQNFSF QPCKE---TQ IPLKLSR--- ---------- 
Cyp3a13    RFALINMKVA LVRVLQNFTV QPCKE---TE IPLKLSK--- ---------- 
Cyp3a16    RFALMNMKLA LIKVLQNFSF QPCKE---TQ IPLKLSR--- ---------- 
Cyp3a25    RFALISIKLA VIGVLQNFTV QPCEE---TQ IPLKISR--- ---------- 
Cyp3a59    RFALISMKLA VIGVLQNFTV QPCEE---TQ IPLKISR--- ---------- 
Cyp3a57    RFALISVKLA VTGVLQNFTV QPCEE---TQ IPVKISR--- ---------- 
Cyp3a41    RFAFMTMKLA LTKVMQNFSF QPCQE---TQ IPLKLSR--- ---------- 
Cyp3a44    RFALMNMKLA VTKVLQNFSF QPCQE---TQ IPLKLSR--- ---------- 
Cyp4a10    QFAMSELKVI VALTLLRFEL LPDPT---RV PMPLA----- ---------- 
Cyp4a31    QFAMSELKVI VALTLLRFEL LPDPT---RV PMSLA----- ---------- 
Cyp4a32    QFAMSELKVI VALTLLHFEL LPDPT---RV PEPLA----- ---------- 
Cyp4a12a   QFAMNELKVA VALTLLRFEL LPDPT---RV PIPIP----- ---------- 
Cyp4a12b   QFAMNELKVA VALTLLRFEL LPDPT---RV PIPIP----- ---------- 
Cyp4a14    QFAMNELKVA VALTLLRFEL LPDPT---RI PVPIA----- ---------- 
Cyp4a30b   QFTMNELKVA VALTLLRFEL LPDPT---RV PILVS----- ---------- 
Cyp4a29    HLAMNVLKVA VALTLLRFEL LPDPS---RV PIPTQ----- ---------- 
Cyp4b1     QFAMNEMKVV TALCLLRFEF SPDPS---KI PIKVP----- ---------- 
Cyp4f13    TFAMSEIKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4f14    TFAMSEMKVA LALTLLRFRL LPD-D---KE PRRQP----- ---------- 
Cyp4f15    TFAMNEMKVA LALTLLRFRV LPD-D---KE PRRKP----- ---------- 
Cyp4f16    TFAMSEMKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4f17    TFAMREMKVA LALTLLRFRV LPG-D---KE PRRKP----- ---------- 
Cyp4f18    TFAMSEMKVA LALTLLRFRV LPD-D---KE PRRKP----- ---------- 
Cyp4f37    TFAMNEMMVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4f39    SFAMAEMRVV VALTLLRFRL SVDRT---HK VRRKP----- ---------- 
Cyp4f40    TFAMSEMKVA LALTLLRFRI LPD-D---KE PRRKP----- ---------- 
Cyp4v3     KFAVMEEKTI LACILRQFWV ESNQK---RE ELGLAG---- ---------- 
Cyp4x1     QFAMLELKVA IALILLHFQV APDLT---RP PAFSS----- ---------- 
Cyp5a1     RLGLLVVKLT ILQVLHKFRF EASPE---TQ VPLQLES--- ---------- 
Cyp7a1     LFAVQEIKQF LILMLSYFEL ELVESHTKCP PLDQS----- ---------- 
Cyp7b1     YFAVNEMKLL LIELLTYFDL EIID--RKPI GLNHS----- ---------- 
Cyp8a1     SYAINSIKQF VVLLLTHFDL ELGSEDTEVP EFDLS----- ---------- 
Cyp8b1     FFALSEMKTF VLLMIMYFDF KLVDPDIPVP PIDPR----- ---------- 
Cyp11a1    RIAELEMTIL LINLLENFRI EVQN----LR DVGTK----- ---------- 
Cyp11b1    RLAEAEMMLL LHHVLKSFHV ETQE----KE DVRMA----- ---------- 
Cyp11b2    RLAEVEMMLL LHHILKTFQV ETLR----QE DVQMA----- ---------- 
Cyp17      ALARQELFIF MALLLQRFDF DVSDD---KQ LPCLV----- ---------- 
Cyp19      YIAMVMMKVV LVTLLRRFQV KTLQK---RC IENIP----- ---------- 
Cyp20      XFAYMVTAVL VSVLLEKLRL LAVDR---QV VEMKY----- ---------- 
Cyp21      PLARLELFVV LARLLQAFTL LPPPD---GT LPSLQ----- ---------- 
Cyp24      RLAELQLHLA LCWIIQKYNI VATD----SE PVEML----- ---------- 
Cyp26a1    EFAKILLKIF TVELARHCDW QLLN---GPP TMKTS----- ---------- 
Cyp26b1    HLAKLFLKVL AVELASTSRF ELATR--TFP RITLV----- ---------- 
Cyp26c1    ELAQAVLQLL AVELVRTARW ELATP--AFP VMQTV----- ---------- 
Cyp27a1    RIAELEMQLM LSRLVQKYEI ALAPG---MG EVKTV----- ---------- 
Cyp27b1    RLAELELQMA LSQILTHFEV LPEPG---AL PIKPM----- ---------- 
Cyp39      WFALLEIQLC IILVLYKYEC SLLDP--LPK QS--S----- ---------- 
Cyp46      QFAQMEVKVV MAKLLQRIEF RLVPG---QR FGLQE----- ---------- 
Cyp51      NFAYVQIKTI WSTMLRLYEF DLING--YFP TVN------- ---------- 
CYP1A1h    TIARWEVFLF LAILLQRVEF SVPLG----V KVDMT----- ---------- 
CYP1A2h    VLAKWEIFLF LAILLQQLEF SVPPG----V KVDLT----- ---------- 
CYP1B1h    ELSKMQLFLF ISILAHQCDF RANPN----E PAKMN----- ---------- 
CYP2A6     GLARMELFLF FTTVMQNFRL KSSQS---PK DIDVS----- ---------- 
CYP2A7     GLARMELFLF FTTVMQNFRL KSSQS---PK DIDVS----- ---------- 
CYP2A13    GLARMELFLF FTTIMQNFRF KSPQS---PK DIDVS----- ---------- 
CYP2B6     GIARAELFLF FTTILQNFSM ASPVA---PE DIDLT----- ---------- 
CYP2C8     GLARMELFLF LTTILQNFNL KSVDD---LK NLNTT----- ---------- 
CYP2C9     ALAGMELFLF LTSILQNFNL KSLVD---PK NLDTT----- ---------- 
CYP2C18    GLARMELFLF LTTILQNFNL KSQVD---PK DIDIT----- ---------- 
CYP2C19    GLARMELFLF LTFILQNFNL KSLID---PK DLDTT----- ---------- 
CYP2D6     PLARMELFLF FTSLLQHFSF SVPTG---QP RPSHH----- ---------- 
CYP2E1h    GLARMELFLL LCAILQHFNL KPLVD---PK DIDLS----- ---------- 
CYP2F1     LLARMELFLY LTAILQSFSL QPLGA---PE DIDLT----- ---------- 
CYP2G2P    AMDRMELFLY FTSTLQNFSL HSLVP---PV DIDIT----- ---------- 
CYP2J2     QLARTELFIF FTSLMQKFTF RPPNN----E KLSLK----- ---------- 
CYP2R1h    HLARMEMFLF FTALLQRFHL HFPHE----L VPDLK----- ---------- 
CYP2S1h    GLAKAEVFLF FTTILQAFSL ESPCP---PD TLSLK----- ---------- 
CYP2T2P    GLAHSGIFLF LTATLQRFCL LPVVR---PG TINLT----- ---------- 
CYP2U1h    QLAKMELFLM FVSLMQSFAF ALPED---SK KPLLT----- ---------- 
CYP3A4     RFALMNMKLA LIRVLQNFSF KPCKE---TQ IPLKLSL--- ---------- 
CYP3A5     RFALMNMKLA LIRVLQNFSF KPCKE---TQ IPLKLDT--- ---------- 
CYP3A7     RFALVNMKLA LVRVLQNFSF KPCKE---TQ IPLKLRF--- ---------- 
CYP3A43    RFALTNIKLA VIRALQNFSF KPCKE---TQ IPLKLDN--- ---------- 
CYP4A11    QFAMNELKVA TALTLLRFEL LPDPT---RI PIPIA----- ---------- 
CYP4A22    QFAMNQLKVA RALTLLRFEL LPDPT---RI PIPMA----- ---------- 
CYP4B1h    QFAMSEMKVV TAMCLLRFEF SLDPS---RL PIKMP----- ---------- 
CYP4F2     TFAMAEMKVV LALTLLAFRV LPD-H---TE PRRKP----- ---------- 
CYP4F3     AFAMAEMKVV LGLTLLAFRV LPD-H---TE PRRKP----- ---------- 
CYP4F8     KFAMAEMKVV LALTLLRFRI LPD-H---RE PRRTP----- ---------- 
CYP4F11    AFAMAEMKVV LALTLLHFRI LPT-H---IE PRRKP----- ---------- 
CYP4F12    AFAMAEMKVV LALMLLHFRF LPD-H---TE PRRKL----- ---------- 
CYP4F22    SFAMAELRVV VALTLLRFRL SVDRT---RK VRRKP----- ---------- 
CYP4F23P   TFAMAEMKVV LALTLLRFRV LPD-H---AE PRRKL----- ---------- 
CYP4V2     KFAVMEEKTI LSCILRHFWI ESNQK---RE ELGLEG---- ---------- 
CYP4X1h    EFAMIELKVT IALILLHFRV TPDPT---RP LTFPN----- ---------- 
CYP4Z1     HFAIIECKVA VALTLLRFKL APDHS---RP PQPVR----- ---------- 
CYP5A1h    RLGLLEVKLT LLHVLHKFRF QACPE---TQ VPLQLES--- ---------- 
CYP7A1h    LFAIHEIKQF LILMLSYFEL ELIEGQAKCP PLDQS----- ---------- 
CYP7B1h    FFALMEIKQL LVILLTYFDL EIID--DKPI GLNYS----- ---------- 
CYP8A1h    SYAVNSIKQF VFLVLVHLDL ELINADVEIP EFDLS----- ---------- 
CYP8B1h    FFALSEVKLF ILLMVTHFDL ELVDPDTPLP HVDPQ----- ---------- 
CYP11A1h   RIAELEMTIF LINMLENFRV EIQH----LS DVGTT----- ---------- 
CYP11B1h   RLAEAEMLLL LHHVLKHLQV ETLT----QE DIKMV----- ---------- 
CYP11B2h   RLAEAEMLLL LHHVLKHFLV ETLT----QE DIKMV----- ---------- 
CYP17h     ILARQELFLI MAWLLQRFDL EVPDD---GQ LPSLE----- ---------- 
CYP19h     YIAMVMMKAI LVTLLRRFHV KTLQG---QC VESIQ----- ---------- 
CYP20h     RFAYMVTTVL LSVLVKRLHL LSVEG---QV IETKY----- ---------- 
CYP21A2h   PLARLELFVV LTRLLQAFTL LPSGD----A LPSLQ----- ---------- 
CYP24h     RLAELQLHLA LCWIVRKYDI QATD----NE PVEML----- ---------- 
CYP26A1h   EFAKILLKIF TVELARHCDW QLLN---GPP TMKTS----- ---------- 
CYP26B1h   HLAKLFLKVL AVELASTSRF ELATR--TFP RITLV----- ---------- 
CYP26C1h   ELAQAVLQLL AVELVRTARW ELATP--AFP AMQTV----- ---------- 
CYP27A1h   RIAELEMQLL LARLIQKYKV VLAPE---TG ELKSV----- ---------- 
CYP27B1h   RLAELELQMA LAQILTHFEV QPEPG---AA PVRPK----- ---------- 
CYP27C1h   RIAELEIHLV VIQLLQHFEI KTSSQ---TN AVHAK----- ---------- 
CYP39A1h   WFALLEVQMC IILILYKYDC SLLDP--LPK QS--Y----- ---------- 
CYP46h     QFAQMEVKVV MAKLLQRLEF RLVPG---QR FGLQE----- ---------- 
CYP51h     NFAYVQIKTI WSTMLRLYEF DLIDG--YFP TVN------- ---------- 

Cyp1a1     ---------- ---------- -----PTYGL TLKHARCEHF QVQMRSSGPQ 
Cyp1a2     ---------- ---------- -----PNYGL TMKPGTCEHV QAWPRFSK-- 
Cyp1b1     ---------- ---------- -----FSYGL TIKPKSFRIH VSLRESMELL 
Cyp2a4     ---------- ---------- ----PRLVGF VTIPPTYTMS FLSR------ 
Cyp2a5     ---------- ---------- ----PRLVGF ATIPPTYTMS FLSR------ 
Cyp2a12    ---------- ---------- ----PTPEGF TRIIPKYTMS FVPI------ 
Cyp2a22    ---------- ---------- ----PKPEGF TRIIPKYTMS FVPI------ 
Cyp2b9     ---------- ---------- ----PKESGI GKIPPAHQIY FLAR------ 
Cyp2b10    ---------- ---------- ----PKESGI GKIPPTYQIC FLAR------ 
Cyp2b13    ---------- ---------- ----PKESGI GKIPPTYQIC FLAR------ 
Cyp2b19    ---------- ---------- ----PNNSGA TKTPPQYQIH FLSR------ 
Cyp2b23    ---------- ---------- ----PKESGF VKIPPVYRIC FLPR------ 
Cyp2c29    ---------- ---------- ----PVMNGF ASLPPPYQLC FIPL------ 
Cyp2c37    ---------- ---------- ----PMLIGL GSVPPAFQLC FIPS------ 
Cyp2c38    ---------- ---------- ----PFVNGL IALPPHYQLC FIPL------ 
Cyp2c39    ---------- ---------- ----PFVNGL IALPPHYQVC IIPR------ 
Cyp2c40    ---------- ---------- ----PKHSGF SKIPPNFQMC FIPVE----- 
Cyp2c44    ---------- ---------- ----PVTTGL FNLPPPYKLR LVPR------ 
Cyp2c50    ---------- ---------- ----PMLIGL ASVPPAFQLC FIPS------ 
Cyp2c54    ---------- ---------- ----PMLIGL GSVPPAFQLC FIPS------ 
Cyp2c55    ---------- ---------- ----PVANTF GRVPPSYQLY FIPR------ 
Cyp2c65    ---------- ---------- ----PVANGF ASVPPKFQIC FIPI------ 
Cyp2c66    ---------- ---------- ----PVANGF VSVPPKFQIC FISI------ 
Cyp2c67    ---------- ---------- ----PKHSGF SKIPPNFQMC FIPVE----- 
Cyp2c68    ---------- ---------- ---------- ---------- ---------- 
Cyp2c69    ---------- ---------- ----PKYSGF SKIPPKFQMC FIPVE----- 
Cyp2c70    ---------- ---------- ----PVQTGL LHVPPPFELC FIPV------ 
Cyp2ac1    ---------- ---------- ----PDIGFI MQSQPHKICA LVRASAL--- 
Cyp2ab1    ---------- ---------- -----YVFGG TLQPQPQKIC AVLR------ 
Cyp2d9     ---------- ---------- -----GVYGI LVAPSPYQLC AVVRDQGH-- 
Cyp2d10    ---------- ---------- -----GVFPF PVAPYPYQLC AVMREQGH-- 
Cyp2d34    ---------- ---------- -----RIFAI PVAPYPYQVC AIMREQGH-- 
Cyp2d11    ---------- ---------- -----RVHAI PVAPFPYQLC AVMHEQGH-- 
Cyp2d12    ---------- ---------- -----RVFFI MVAPSPYQLC AVIREQGH-- 
Cyp2d13    ---------- ---------- -----GIFTF LVSPSPYQLC AFTRDQATN- 
Cyp2d40    ---------- ---------- -----GIYSM VVSPAPYQLC AVVR------ 
Cyp2d22    ---------- ---------- -----GVFRA LTTPCPYQLC ALPR------ 
Cyp2d26    ---------- ---------- -----GIYTM PVTPEPYQLC AVAR------ 
Cyp2e1     ---------- ---------- ----PVTIGF GSIPREFKLC VIPRS----- 
Cyp2f2     ---------- ---------- ----PLSSGL GNLPRPFQLC MHIR------ 
Cyp2g1     ---------- ---------- ----HKISGF GNIPPVYELC FMAR------ 
Cyp2j5     ---------- ---------- -----FRMGL ILSPASYRIC AIPRV----- 
Cyp2j6     ---------- ---------- -----FRNGL TLSPVSHRIC AVPRQ----- 
Cyp2j7     ---------- ---------- -----FRMSV PISPVSYCIC AVPRQ----- 
Cyp2j8     ---------- ---------- -----FKMGV ALSPVSYCIC AVPR------ 
Cyp2j9     ---------- ---------- -----FRMAA TVSPVSHRLC AIPRL----- 
Cyp2j13    ---------- ---------- -----FRLGI TISPVSYRIG AVPRQ----- 
Cyp2j12    ---------- ---------- -----FRNGL TLSPVSHCIC AVPRH----- 
cyp2j11    ---------- ---------- -----FRMGL TLAPVSYRIC AVPRL----- 
Cyp2r1     ---------- ---------- -----PRLGM TLQPQPYLIC AERR------ 
Cyp2s1     ---------- ---------- ----PAISGL FNIPPDFQLR VWPTGDQSR- 
Cyp2t4     ---------- ---------- ----PQCTGL GNVPPAFQLR LVAR------ 
Cyp2U1     ---------- ---------- ---------- ---------- ---------- 
Cyp2w1     ---------- ---------- -----PAPAF TMRPPAQ--- ---------- 
CYP2W1h    ---------- ---------- -----PARAF TMRPRAQALC AVPRP----- 
Cyp3a11    ---------- ---------- -------QGL LQPEKPIVLK VVPRDAVITG 
Cyp3a13    ---------- ---------- -------QGL LQPENPLLLK VVSRDETVSD 
Cyp3a16    ---------- ---------- -------ELL LQPVKPIVLK VVPRDAVITG 
Cyp3a25    ---------- ---------- -------EPI FQPEKPIILK VVSRDKPRTG 
Cyp3a59    ---------- ---------- -------EPV FQPEKPIILK VVSRDKPRT- 
Cyp3a57    ---------- ---------- -------QPI FRPEKPIILK FVSRDKPRTG 
Cyp3a41    ---------- ---------- -------QGL LQPEKPIVLK VVPRDVVITG 
Cyp3a44    ---------- ---------- -------QGI LQPEKPIVLK VVPRDAVITG 
Cyp4a10    ---------- ---------- -------RLV LKSKNGIYLH LKKLH----- 
Cyp4a31    ---------- ---------- -------RFV LKSKNGIYLH LKKVH----- 
Cyp4a32    ---------- ---------- -------RIV LKSKNGIYLH LKKLH----- 
Cyp4a12a   ---------- ---------- -------RIV LKSKNGIHLH LKKLQ----- 
Cyp4a12b   ---------- ---------- -------RIV LKSKNGIHLH LKKLQ----- 
Cyp4a14    ---------- ---------- -------RLV LKSKNGIHLC LKKLR----- 
Cyp4a30b   ---------- ---------- -------KIV LKSKNGIYLH TKKL------ 
Cyp4a29    ---------- ---------- -------QLV LKSKNGIYLH LRKL------ 
Cyp4b1     ---------- ---------- -------QLI LRSKNGIHLY LKPLGPGSGK 
Cyp4f13    ---------- ---------- -------ELI LRAEGGLWLR VEPLSAGAQ- 
Cyp4f14    ---------- ---------- -------ELI LRAEGGLWLR VEPLSAGAH- 
Cyp4f15    ---------- ---------- -------ELI LRAEGGLWLR VEPLSTQ--- 
Cyp4f16    ---------- ---------- -------EII LRAEGGLWLR VEPLSKGAQ- 
Cyp4f17    ---------- ---------- -------ELI LRAEGGLWLR VEPLSKGTQ- 
Cyp4f18    ---------- ---------- -------ELI LRAEGGLWLK VEPLSAGAQ- 
Cyp4f37    ---------- ---------- -------EII LRAEGGLWLR VEPLS----- 
Cyp4f39    ---------- ---------- -------ELI LRTENGLWLN VEPLPSRA-- 
Cyp4f40    ---------- ---------- -------ELI LRAEGGLWLR VEPLSTQA-- 
Cyp4v3     ---------- ---------- -------DLI LRPNNGIWIK LKRRHEDDP- 
Cyp4x1     ---------- ---------- -------HTV LRPKHGIYLH LKKL------ 
Cyp5a1     ---------- ---------- -------KSA LGPKNGVYIK IVSR------ 
Cyp7a1     ---------- ---------- ----RAGLGI LPPLNDIEFK YKLKH----- 
Cyp7b1     ---------- ---------- ----RMFLGI QHPDSAVSFR YKAKSWRS-- 
Cyp8a1     ---------- ---------- ----RYGFGL MQPEEDVPIR YRARL----- 
Cyp8b1     ---------- ---------- ----RWGFGT SQPSHEVRFL YRLKPVQ--- 
Cyp11a1    ---------- ---------- ------FSLI LMPENPILFN FQPLKQDLGP 
Cyp11b1    ---------- ---------- ------YRFV LMPSSSPLLT FRPVN----- 
Cyp11b2    ---------- ---------- ------YRFV LMPSSSPVLT FRPVS----- 
Cyp17      ----G----- ---------- ----DPKVVF LIDPFKVKIT VRQAWKDAQV 
Cyp19      ---------- ----K-KN-- ----DLSLHP NEDRHLVEII FSPRNSDKYL 
Cyp20      ---------- ---------- -------ELV TSAREEAWIT VSKRH----- 
Cyp21      ----P----- ---------- ----QPYAGI NLPIPPFQVR LQPRNLAPQD 
Cyp24      ---------- ---------- ------HLGI LVPSRELPIA FCPR------ 
Cyp26a1    ---------- ---------- ----PTVYPV DNLPARFTYF QGDI------ 
Cyp26b1    ---------- ---------- ----PVLHPV DGLSVKFFGL DSNQNEILPE 
Cyp26c1    ---------- ---------- ----PIVHPV DGLLLFFHPL PTSGAGDGLP 
Cyp27a1    ---------- ---------- ------SRIV LVPSKKVRLH FLQRQ----- 
Cyp27b1    ---------- ---------- ------TRTV LVPERSINLQ FVDR------ 
Cyp39      ---------- ---------- ----RHLVGV PQPAGKCRIE YKQRA----- 
Cyp46      ---------- ---------- -------QAT LKPLDPVLCT LRPRGWQPAP 
Cyp51      ---------- ---------- -----YTTMI HTPENPVIRY KRRSK----- 
CYP1A1h    ---------- ---------- -----PIYGL TMKHACCEHF QMQLRS---- 
CYP1A2h    ---------- ---------- -----PIYGL TMKHARCEHV QARRFSIN-- 
CYP1B1h    ---------- ---------- -----FSYGL TIKPKSFKVN VTLRESMELL 
CYP2A6     ---------- ---------- ----PKHVGF ATIPRNYTMS FLPR------ 
CYP2A7     ---------- ---------- ----PKHVVF ATIPRNYTMS FLPR------ 
CYP2A13    ---------- ---------- ----PKHVGF ATIPRNYTMS FLPR------ 
CYP2B6     ---------- ---------- ----PQECGV GKIPPTYQIR FLPR------ 
CYP2C8     ---------- ---------- ----AVTKGI VSLPPSYQIC FIPV------ 
CYP2C9     ---------- ---------- ----PVVNGF ASVPPFYQLC FIPV------ 
CYP2C18    ---------- ---------- ----PIANAF GRVPPLYQLC FIPV------ 
CYP2C19    ---------- ---------- ----PVVNGF ASVPPFYQLC FIPV------ 
CYP2D6     ---------- ---------- -----GVFAF LVSPSPYELC AVPR------ 
CYP2E1h    ---------- ---------- ----PIHIGF GCIPPRYKLC VIPRS----- 
CYP2F1     ---------- ---------- ----PLSSGL GNLPRPFQLC LRPR------ 
CYP2G2P    ---------- ---------- ----PKLSGF GNIPPTYELC LVAR------ 
CYP2J2     ---------- ---------- -----FRMGI TISPVSHRLC ---------- 
CYP2R1h    ---------- ---------- -----PRLGM TLQPQPYLIC AERR------ 
CYP2S1h    ---------- ---------- ----PTVSGL FNIPPAFQLQ VRPTDLHSTT 
CYP2T2P    ---------- ---------- -----QCTGL GSVPPDFQLQ PVAC------ 
CYP2U1h    ---------- ---------- -----GRFGL TLAPHPFNIT ISRR------ 
CYP3A4     ---------- ---------- -------GGL LQPEKPVVLK VESRDGTVSG 
CYP3A5     ---------- ---------- -------QGL LQPEKPIVLK VDSRDGTLSG 
CYP3A7     ---------- ---------- -------GGL LLTEKPIVLK AESRDETVSG 
CYP3A43    ---------- ---------- -------LPI LQPEKPIVLK VHLRDGITSG 
CYP4A11    ---------- ---------- -------RLV LKSKNGIHLR LRRLPNPCED 
CYP4A22    ---------- ---------- -------RLV LKSKNGIHLR LRRLPNPCED 
CYP4B1h    ---------- ---------- -------QLV LRSKNGFHLH LKPLGPGSGK 
CYP4F2     ---------- ---------- -------ELV LRAEGGLWLR VEPLS----- 
CYP4F3     ---------- ---------- -------ELV LRAEGGLWLR VEPLS----- 
CYP4F8     ---------- ---------- -------EIV LRAEDGLWLR VEPLG----- 
CYP4F11    ---------- ---------- -------ELI LRAEGGLWLR VEPLGANSQ- 
CYP4F12    ---------- ---------- -------ELI MRAEGGLWLR VEPLNVGLQ- 
CYP4F22    ---------- ---------- -------ELI LRTENGLWLK VEPLPPRA-- 
CYP4F23P   ---------- ---------- -------ELI VRAEDGLWLR VEPLSADLQ- 
CYP4V2     ---------- ---------- -------QLI LRPSNGIWIK LKRRNADER- 
CYP4X1h    ---------- ---------- -------HFI LKPKNGMYLH LKKL------ 
CYP4Z1     ---------- ---------- -------QVV LKSKNGIHVF AKKV------ 
CYP5A1h    ---------- ---------- -------KSA LGPKNGVYIK IVSR------ 
CYP7A1h    ---------- ---------- ----RAGLGI LPPLNDIEFK YKFKHL---- 
CYP7B1h    ---------- ---------- ----RLLFGI QYPDSDVLFR YKVKS----- 
CYP8A1h    ---------- ---------- ----RYGFGL MQPEHDVPVR YRIRP----- 
CYP8B1h    ---------- ---------- ----RWGFGT MQPSHDVRFR YRLHPTE--- 
CYP11A1h   ---------- ---------- ------FNLI LMPEKPISFT FWPFNQEATQ 
CYP11B1h   ---------- ---------- ------YSFI LRPSMCPLLT FRAIN----- 
CYP11B2h   ---------- ---------- ------YSFI LRPGTSPLLT FRAIN----- 
CYP17h     ----G----- ---------- ----IPKVVF LIDSFKVKIK VRQAWREAQA 
CYP19h     ---------- ----K-IH-- ----DLSLHP DETKNMLEMI FTPRNSDRCL 
CYP20h     ---------- ---------- -------ELV TSSREEAWIT VSKRY----- 
CYP21A2h   ----P----- ---------- ----LPHCSV ILKMQPFQVR LQPRGMGAHS 
CYP24h     ---------- ---------- ------HSGT LVPSRELPIA FCQR------ 
CYP26A1h   ---------- ---------- ----PTVYPV DNLPARFTHF HGEI------ 
CYP26B1h   ---------- ---------- ----PVLHPV DGLSVKFFGL DSNQNEILPE 
CYP26C1h   ---------- ---------- ----PIVHPV DGLRLFFHPL TPSVAGNGLC 
CYP27A1h   ---------- ---------- ------ARIV LVPNKKVGLQ FLQRQC---- 
CYP27B1h   ---------- ---------- ------TRTV LVPERSINLQ FLDR------ 
CYP27C1h   ---------- ---------- ------THGL LTPGGPIHVR FVNRK----- 
CYP39A1h   ---------- ---------- ----LHLVGV PQPEGQCRIE YKQRI----- 
CYP46h     ---------- ---------- -------QAT LKPLDPVLCT LRPRGWQPAP 
CYP51h     ---------- ---------- -----YTTMI HTPENPVIRY KRRSK----- 

Cyp1a1     HLQA------ ----
Cyp1a2     ---------- ----
Cyp1b1     DNAVKKLQTE EGCK
Cyp2a4     ---------- ----
Cyp2a5     ---------- ----
Cyp2a12    ---------- ----
Cyp2a22    ---------- ----
Cyp2b9     ---------- ----
Cyp2b10    ---------- ----
Cyp2b13    ---------- ----
Cyp2b19    ---------- ----
Cyp2b23    ---------- ----
Cyp2c29    ---------- ----
Cyp2c37    ---------- ----
Cyp2c38    ---------- ----
Cyp2c39    ---------- ----
Cyp2c40    ---------- ----
Cyp2c44    ---------- ----
Cyp2c50    ---------- ----
Cyp2c54    ---------- ----
Cyp2c55    ---------- ----
Cyp2c65    ---------- ----
Cyp2c66    ---------- ----
Cyp2c67    ---------- ----
Cyp2c68    ---------- ----
Cyp2c69    ---------- ----
Cyp2c70    ---------- ----
Cyp2ac1    ---------- ----
Cyp2ab1    ---------- ----
Cyp2d9     ---------- ----
Cyp2d10    ---------- ----
Cyp2d34    ---------- ----
Cyp2d11    ---------- ----
Cyp2d12    ---------- ----
Cyp2d13    ---------- ----
Cyp2d40    ---------- ----
Cyp2d22    ---------- ----
Cyp2d26    ---------- ----
Cyp2e1     ---------- ----
Cyp2f2     ---------- ----
Cyp2g1     ---------- ----
Cyp2j5     ---------- ----
Cyp2j6     ---------- ----
Cyp2j7     ---------- ----
Cyp2j8     ---------- ----
Cyp2j9     ---------- ----
Cyp2j13    ---------- ----
Cyp2j12    ---------- ----
cyp2j11    ---------- ----
Cyp2r1     ---------- ----
Cyp2s1     ---------- ----
Cyp2t4     ---------- ----
Cyp2U1     ---------- ----
Cyp2w1     ---------- ----
CYP2W1h    ---------- ----
Cyp3a11    A--------- ----
Cyp3a13    E--------- ----
Cyp3a16    A--------- ----
Cyp3a25    S--------- ----
Cyp3a59    ---------- ----
Cyp3a57    P--------- ----
Cyp3a41    A--------- ----
Cyp3a44    A--------- ----
Cyp4a10    ---------- ----
Cyp4a31    ---------- ----
Cyp4a32    ---------- ----
Cyp4a12a   ---------- ----
Cyp4a12b   ---------- ----
Cyp4a14    ---------- ----
Cyp4a30b   ---------- ----
Cyp4a29    ---------- ----
Cyp4b1     ---------- ----
Cyp4f13    ---------- ----
Cyp4f14    ---------- ----
Cyp4f15    ---------- ----
Cyp4f16    ---------- ----
Cyp4f17    ---------- ----
Cyp4f18    ---------- ----
Cyp4f37    ---------- ----
Cyp4f39    ---------- ----
Cyp4f40    ---------- ----
Cyp4v3     ---------- ----
Cyp4x1     ---------- ----
Cyp5a1     ---------- ----
Cyp7a1     ---------- ----
Cyp7b1     ---------- ----
Cyp8a1     ---------- ----
Cyp8b1     ---------- ----
Cyp11a1    AVTRKDNTVN ----
Cyp11b1    ---------- ----
Cyp11b2    ---------- ----
Cyp17      EVST------ ----
Cyp19      QQ-------- ----
Cyp20      ---------- ----
Cyp21      QGERP----- ----
Cyp24      ---------- ----
Cyp26a1    ---------- ----
Cyp26b1    TEAMLSATV- ----
Cyp26c1    F--------- ----
Cyp27a1    ---------- ----
Cyp27b1    ---------- ----
Cyp39      ---------- ----
Cyp46      PPPPC----- ----
Cyp51      ---------- ----
CYP1A1h    ---------- ----
CYP1A2h    ---------- ----
CYP1B1h    DSAVQNLQAK ETCQ
CYP2A6     ---------- ----
CYP2A7     ---------- ----
CYP2A13    ---------- ----
CYP2B6     ---------- ----
CYP2C8     ---------- ----
CYP2C9     ---------- ----
CYP2C18    ---------- ----
CYP2C19    ---------- ----
CYP2D6     ---------- ----
CYP2E1h    ---------- ----
CYP2F1     ---------- ----
CYP2G2P    ---------- ----
CYP2J2     ---------- ----
CYP2R1h    ---------- ----
CYP2S1h    QTR------- ----
CYP2T2P    ---------- ----
CYP2U1h    ---------- ----
CYP3A4     A--------- ----
CYP3A5     E--------- ----
CYP3A7     A--------- ----
CYP3A43    P--------- ----
CYP4A11    KDQL------ ----
CYP4A22    KDQL------ ----
CYP4B1h    ---------- ----
CYP4F2     ---------- ----
CYP4F3     ---------- ----
CYP4F8     ---------- ----
CYP4F11    ---------- ----
CYP4F12    ---------- ----
CYP4F22    ---------- ----
CYP4F23P   ---------- ----
CYP4V2     ---------- ----
CYP4X1h    ---------- ----
CYP4Z1     ---------- ----
CYP5A1h    ---------- ----
CYP7A1h    ---------- ----
CYP7B1h    ---------- ----
CYP8A1h    ---------- ----
CYP8B1h    ---------- ----
CYP11A1h   Q--------- ----
CYP11B1h   ---------- ----
CYP11B2h   ---------- ----
CYP17h     EGST------ ----
CYP19h     EH-------- ----
CYP20h     ---------- ----
CYP21A2h   PGQNQ----- ----
CYP24h     ---------- ----
CYP26A1h   ---------- ----
CYP26B1h   TEAMLSATV- ----
CYP26C1h   L--------- ----
CYP27A1h   ---------- ----
CYP27B1h   ---------- ----
CYP27C1h   ---------- ----
CYP39A1h   ---------- ----
CYP46h     PPPPC----- ----
CYP51h     ---------- ----