ࡱ> UWT :bjbjв 2fк_к_1rr8PDlTTT$ TTTTTTTTTTTTTTT |PTT0TTTTh TTTTTTTTTTTTTTTTTTTTTTTTTrX : 64 sequence fragments from purple sea urchin + 3 complete sequences Strongylocentrotus purpuratus No mito clan seqs found yet. Only 3 different CYP3 clan seqs. Mostly CYP2 clan as in C. elegans. The CYP4 like sequences are most like 4V5. D. Nelson August 11, 2004 CYP51 clan >AY496941 BG786122 CYP51 MANSVNIFESVGGVFGEMTLATMILVSTIFVLGIAWAFKSLLGP QNKDVKLPPRLPTGIPFLGQAVAFNQSPIDFLEDAYEKYGDVFSFTMVGKTFTYLIGS EASALLFNSKNENLNAEEVYSNLTVPVFGKGVAYDVPNPVFVEQKKMLKTGLNIQQFK RHIPLIEEETREYFNRWGDSGEKNLFVALSELIILTASRCLHGKEIRSMLDEEVAQLY ADLDGGFTHLAWLAPSWIPFPSFLRRDRAHRKIKQIFYKAIAKRRETGVENDMLQTLI DSKYKSGRPLSDDEIAGMCIGLLLAGQHTSSTTSAWLGFFLARDKEVQDRCNAEQIKV CGDASTEVSYDQLKDMQLLDHCVKEALRLRPPIMTMMRVAKSPLTYKDMTIPAGHQVC VSPTVNQRLKDNWMPGPKEFNPDRFLDESKSNSEKFSYVPFGAGRHRCIGENFAYVQI KTIWSVMLRIFEFELVDGYFPGINYQTMIHTPLNPIIRYKRRTESL* CYP2 clan >CD310809 32% to CYP1B1 CYP1 like seq in the CYP2 clan GVVTATLALWTIVRPKRF 67 PPGPRGLPIVGSIFSMNDSPEIVFGEWAKRYGDIFGFKAGERWMVVLNRQALIKEA 234 235 VLKQGVDFAGRPDFYSLEIFTDGFKDIAFSPYSETWKLHRKLAHTALRHFATGKPLQD 408 409 LISSVYPKVDKKLAMTEGQPIDPKVLINLIMYNVLAQMCFGRSYELEDPTVAQWMDT 579 580 NDDLNEKFGLGLAADMFSXARYIPTSGPRMIXELTXKLXGFLRLQVDETREHYD 741 >CD319179 CD290182 CD312632 42% to CD310809 51% to 1C1 505 KSSGDEAKPLPGPWGIPVLGNMLSLGRSAPHLSLTALAKKFGSIFQIRLGSRPVL 341 340 VLNGYEAIQKALIKQAVVFSGRPDLYTFELIKSGVKSGTSLSFGNYGESWKLHRKLAESS 161 160 LRHFTAGSQVKFVESVVSTEASELVQYFKSI 68 >CD306283 CD306762 4 aa diffs to CD310809 (alleles?) CYP1 like MIDLIGAGESGFGQFNALTITATL GVVTATLVLWTIVRPKRFPPGPRGLPIVGSIFSMNDSPEVVFG 234 235 EWAKRYGDIFGFKAGERWMVVLNRQALIKEAVLKQGVDFAGRPDFYSLEIFTDGFKDIA 411 412 FSPYSETWKLHRXLAHTALRHFATGKPLQDLISSVYPKVDKKVAMTEGQPIDPKVLINL 588 589 IMYNVLAQ 612 >AZ185855 34% to 1C1 ILQEANNLVNHFEAQNEKPFDPQCDLHIASLNILCNFVFGERYEHDNPEMREILDFSAEISKLLSPMHPVNAMPWLRHFP >AZ186969 42% to CYP17 DLITWSKRYCTSLRLKPSTFFIPSSQVTSVMANFCQVHHNEDAWDQPEEFLPERFLNRPR 135 AT*RNLPSCASCPSVGKRRCLGANVAKADL >BG785062 46% to 2X2 65% to CD306283 67% to CD310809 MIDLLGDSSLVQVNGLTITATLGVVAISLALWTMVRPRNFPPGPRGLPIVGSLFSLNDNLEKDFTGWIKQYGDIFGFKLGDTGWSS >AZ193119 45% to 2Y2, 39% to AC149996.1 SKGIGFSNGEVWKEQRKFTHSVFRSLGVGKKSYEDTVSAEMKQLSSVIKEKKSSPFDPS TLFMQAVSNIICSIIFGTQYTYDDDAFKKV >AC149996.1 CD312541, CD303995 AZ193978 CD306524 32% TO CYP2Z2 AND CYP2P seqs. 100399 MSTDFLTHNLSTLLTTGLTIILVVLFSLRRKNDSSKKLTH PPGPSGIPVLGNLLTVAFSKLPQHELINGWSKKYGDVFWFKIFGTGVVIINDKEVMQKTFQNTD VCDRAPFFASDYVLGRENN 100031 () 98599 GIAFANGGSWKEQRKFFVSIFRKVDIGVSRLEDIVGGQVKNIVTQVKNLK 98450 (1) 97795 GEKFDPAIMVNMSIANIITRIITGVTYDWEDKAFQDIVAYSGK LFDISGPAGLFSLNPVFARLPLPVNFEIRRLCRT 97565 97564 IMDFIQVSIDEHRKNFDPNAPVKDFIGSYLKEMASADA 97451 (0) 96732 NNLKSFDDTNMIVSCFDALLGGWETVASTLRWTIYLLSKHPEAQGRMRQEIHDLVGD 96592 96591 ERFPTIADRQYLPLVEATIAECMRFIPAVPIHLPHVTSQDCNIGGFDVPKGSAVAANL 96418 96417 LHFAKSPMFWEDPEVFRPERFLDDAGNFMRGLEPVPFGYG 96298 () 95966 KRQCPGELLARMEMFIFTTFLVQNFELKLP 95877 95875 AGIKDDLQGVLGLTWRPNHYFIEGHPTNANEE* 95777 >AC149996.1 second gene on same contig 34% to 2N10 Fugu 118097 MITELITTSYLTTTVLTCIVGYLVVQLLRRKRYKLPPGPKGWPIIGSYLTLTS 117939 117938 GKYELRDLLNMWAKEYGDLYMFSMFGSRFVILNSYDLVHEAFQSPDFNDRAPILPCNKAL 117759 117758 NRSNT 117744 () 114398 GLISANEGHLWKEQRSFVTQYLRNVKQHNSNFEDLVAAEAAKLIKNFASQEGTFFN 114231 114230 PITDIDVTVSNVITGILTGKTYDYNDEEFVELTKRAQQVFEWMGPGSFFYHVPVLAYMPM 114051 114050 EINKMGDAAAKGMFDFLEKILKRHRQAYNPEDEPKDLIEAFLHEEANKKA 113901 () NVDVGSFTHQCLKQVVWDLMLGGIDSVSTSLSWYFLFMAQYPDVQ 109823 AKVQAELDKVIGRDRLPSLSDRQNLPFTESTSVECYRFCRLINVQIPHRTRCDVKLGGYDI 109641 109640 PKGTNVGTNASWLSSSPSLWENSEEFVPDRFIDKETGLYNSKLEAGLVEFGV () 109116 GRRVCPGEQLARTELFVIFTHILHRFTLRLPEGTPITRDGINGLTHHPKPYKITAAPRR* 108937 >AZ145256 92% to AC149996.1 second gene KVQAELDKVIGRDRLPSLSDRQNLPFTESTSVECYRLCRLINVQIPHRTRCDVKLGGYDIPKGSNVGRNASWLSSSPSLWEXSKNSVPDRFIDKE >AZ209557 8 aa diffs to AZ145256 90% KVQAELDKVIGRDRLPSLSDRHNLPFKKSTSVECYRFCRLINVQIPHRTRCDVKLGGYDI 146 RRGTNVGTNASWLSSSPSLWE >CD340707 52% to AC149996.1 second gene 452 PDRFLTEDGQXDRKREPIFFGTGRRVCPGEQLARTEIFLFITSILQRFTLSLAEGVPKDL 273 272 PCYHSITNRPDPYQIHAEKIV* >CD309158 54% to CD311749 36% to CYP2K and CYP2P MSLLTDYYGVALAILSLVLTLIWYLKNSSSWRYRNLPPGPLGLPILGILPYLDEKNPSVDVLRMSKRYGPI GGFLGSHRAVFLNDYDTIKKTFAR QNDVFSDRPRIAIFELYSDG >CD311749 34% to 2AA1 ands CYP2Ks 54% to CD309158 MGNRRHTTYILALISLVLATISLRIGGQGRRRRRGKL 180 PPGPMGWPIVGMLPYMDPENPAQSVWDMSKQYGSVFCGRLGSHLAVFINDYETIKE 347 348 AFSRKDDAFSDRPRITMFEVYTNGHGVATCYFDNHWKEQRRFAMKAFRHFGVG 506 KPDSVFEEYLMRESKHLLHAYSRXHVAFNLKPFLDMGSLHIISSMTFGNRFSYTE >CD289804 39% to CYP17A2 in CYP2 clan ILADRDSVHSLVGIFSKVHTAEYEDGSERDILDHLVTSGRRYNENNNKKAGINDVMLRET CFDYFGAGFETVSTTLEWCLLYVAAHPDTQP >CD296461 55% to CD338576 41% to CYP2Y1 TVCDILEKGLFTKECEEHQKVFDPNRSPRDLIEAFLLELHKKQQEKVENNGEDMAPTGFN HQQMLHFIADVFAAGTDTTAST LKWSLIHLMKFEDEQRKIQEELDHVIGRDRMPSLEDKP NLPYTQAFLAESLRYGCAGPL VPHGAXEDTKLRGYDIPKGT RGPVIVANLYAVLYDPXVFP EQXQFNPSRFID >CD338576 51% to 2N11 337 TFTKENMYHAVADLFAAGTETTATTLKWALMYMLLHQDVQEKIHKELDDVVGRNRLPSLT 158 157 DRPNLPYTEATLLEIQRFATITPLGVPHAPVQDTVLNGYDIPEGTVILPNL 5 >CD330464 56% to CD306667 39% to CYP2Z2 75 LPTPGVKMVHRMRDELHRFVWDELDSHKKNFDPDNVRDVFDMLLLAQKEAADSGNQDAE 251 252 KLSDTHLVLTVSNMFAAGIQTTTETLYWALAFMVEHRDIQSRCQAEIDKAIGRKRVPVVD 431 432 DRGSLPYTEATLYEVMRY 485 >CD306667 45% to 2U1 89% to CD322241 DTHVFQTIADIFGAGIQTTVETLYWAMALLATYPEIQAKIRTEIDDVIGRDRLPTINDRG KLAYTEASLYEVLRYSSIAPTALPHATTRDTEFGGYHIPKGT VVMINTHSMHYDPQEWDQPDKFMPEHFMMGSGTIRDHPPSFLPX GAGRRGCLGETRAKADLFLIFTW >CD322241 CD337488 50% to 2U1 fugu 90% to CD318421 LVTYPESQAKIRAEIDDVIGRDRLPAINDRGKLPYTEATLYEVLRYSSILPIALP HNTTRDTEFGGYHIPKGTVVMINTHSMHYDPQEWDQPDKFLPEHFMDGSGTVRDHPPSFL PFGAGRRGCLGEAVAKADLFLIFTWFMQNYTFSRAPGXESEDILKMIPQTASGRILLSYE IMINXRD* >CD318421 51% to 2AD1 zebrafish 90% to CD322241 FGGYHIPKGTTVMINTHSMHYDPQEWDQPDKFLPEHFLDDGGTIREHPPSFLPFGA GRRGCLGEAVAKADLFLIFTWFLQNYTFSKAPGKESEDILKMIPKTASGRLLLSYEIMIN KRD* >CD322083 CYP2 clan 46% to 2K10 57% to CD318421 SVFPSLTTVEALPYTRATLYEVMRYQLHMPIAVPHATTCDVNXRGYRIXKGAVVMFNTYS MHYDPNAWESPTSFKPEHFLEDDGSVQQHPSSFLPFGAGRRSCLGEVAAKTDLIVIFTWL LQNYCFKKVPGTETTSLLRVIENSAVGRNLDNYELIMEMRKMKLFTNWINPQC >AZ204399 46% to CD322241 45% to 2U1 581 PEVRKKVQEELDTVIAPGELPSWRDRDRMPCTEATLMEIQRMANVTALTFPHKTTEDTE 405 404 LAGYSIPKDTHVFINLYSVHVDPTQWKEPEKFMPERFLSDEGGVIHNPALMPFSAG 237 >AZ167954 k-helix to perf 54% to 2U1 45% TO CD322241 21 QQVQNELDAVVGRGRQPDTSDRPNLPYCDATLMEIMRLRPVVPISLPHMTSADASLGPYT 200 201 IPKGTIIVPNLWAVHHDPKEWCDPHLFNPNRFLSADGQ 314 >CD297375 36% to 2P4 MASSGYVASSIFLGLQEISFRECIVFVTTCLFVRLLVSRGSFKKSTPPSNPPPP SPTGLPFFGNLFSFQEDMRHLFRKWTNEIGGIFRLRIGPVMDIVVINDVEAVREAFVEKA DAFSDRMVPPLLGEALXKRGSLIWPAGGGWKKPRKFXHSAF >CD323632 62% to CD305862 MSSSVFYYGFTPFILAGLIAFLLSFILVRSGKKKYKNLPPRGPREWPVLGGLPSL AGTDMPHVTIADMAKKYGPIFGMKMGSFYAVILSDYSLVRQAFAKSNDEFSDRPKITMIE NLVQGKGLIVSYFGQMQTEHRRFSLSALRSLGMGKFKMEETIVDEARQLATIFA >CD305862 38% to 2K10, 91% to CD305902 MDFGISL 166 TTFLLGMVTFLVTLMMVWSRTGRTYANLPPKGPPEWPIIGSLLSLAGEHPPHQILANMA 342 343 KKYGPIFSMQMGSFYAVVLSDYSLIKQAFAKSGDDFSDRPKIAMIEHLAEGKGLISGYN 519 520 SPAQIEQRRFTFSALRSLGMGKFRM 594 >CD305902 91% to CD305862 MDFGISLTTFLLGMRTFLVTLMMVWTRTGRTYANLPPKGPPEWPIIGSLLSLSGYHPPHQ ILAIMAKKYGPIFSMQMGSFYAVVLSDYSLIKQAFAKSGDDFSDRPEIAMIDHLAEGEGL ISVYNILAQIEQRRFTFSALQ >CD304889 CYP2 clan 239 MDFRWHQLTPYHLLVTALVGLVAAWFVKHLMRLPKNLPPGPTGLPLLGVLSKFIGTSD 412 413 PLALLSEWADRYGEITSFKLGPQLVVLLNSYDAVAEAFRHPDLQGKPRSRMTEEASGFG 589 590 PNAXLLIGAGTSWKEQRKFTLSVFR 664 >CD304828 CD339829 in the CYP2 Clan TALPFFGNLFSLKPHDEFLDSLMGWSKEYGCIYSLYLGRKLILIV NGSEAVKELTCKTGLDFADRGESVAFLALNPNRLGLFDTLADEEWKRQRKFAYT TLRGMGFGKVSLEPLIQTEARHVISYFKTKVGSLLDPSVAFGVTSSNIINKLVFDRRVDH GSESGDELVRHVRNLMVGDEVAVLALFPSLWPVMRYADSKWMKLYDSWAHIESFFHQEIK IREDRIDA >CD297583 39% to 2Y2 MSSVVNLLLSVIEYIGIVN 210 LLTTITSCLVTFWYIRMNYGASFHYRLPPGPPVIPYPFDFLMALFPSSNRFGRMIFLSKR 389 390 YGDITCLQLGRRMIIMISSPSLVKELIVKQADVTSNRSAPPFFTSVMDYKGGIIF 554 555 SDGEPWQEIRRFSLSALRNFGMGRKGIETRIQEEAXHLCNAFAHTPGRASTPCILP 722 >AZ195502 N-term 41% to 2P4 SVFLGVVIFLLCFWVVRRPKNLPPGPWSLPIIGYNFKPGLIHEAYVDLAKKYGPIFSLRRGSFVFVILNDRESITQALVKSGE 16 >AZ195501 C-term of AZ195502 54% to 2Z2 PLNQPNPSMRGANGITMNPQPYKICAIER* >AZ189543 90% to AZ195502 MFELSATSVFLGVVINILCLWVVRRXKNLPPGPWS LPIIGYNFKPGLIHEAYVDLDKKYGPIFSLEXG*IVFVILNDRESITQALXSQCK 31 >AZ175303 3 aa diffs to AZ195502 N-term ELSATSVFLGVVIFLISFWVVRRPKNLPPGPWSLPIIGYNFKPGLIHEAYVDLAK 112 KYGPIFSLRRGSFVFVILNDRESITEALV >AZ197884 75% to AZ195502 N-term VRRPKNLPPGPWSLPIIGYRFDSGLIHEAFVDLARKYGPVSSVRRGPFLFVVLNDRASMKQALVKSGEFFSDR >CD297323 66% to CD294563 50% to 2P4 GKRMCMGDQLAKMELFLFFTMIVQQIKFSLPPGADPLPMDGLLEIARKPKPFQVQV SAWSD* >CD294563 58% to 2U1 52% to CD295323 INILHIHHDPKIWGDPEVFRP*RFLTEDGTALIKHEAYIPFGVGRRVCLGEQLAKMELFL FFTNILQQFKITMPPGVQPNYDFGHRALTTLGS* >AZ179988 67% to 2U1 fugu 59% to CD294563 GTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQ >CD295323 LWDEPEEFNPHRFLSEDGKTVIKPQDAFTVFGAGRRVCLGEQLARMEFFLFATTLMQRFR FRLPEGESGDFGFEHCLGTIAPKNFKILAQER* >AZ207850, AZ190486 AZ194693 4aa diffs to AZ194695, 48% to 2U1 LPLLSGRRDCLGMQLAMMETFLLFTNLFQQFEFKLPPDQPTHSMRGHPGLTMPPESYKICAIER >AZ194695 4 aa diffs to AZ207850, AZ190486 (allele?) LPLLSGRRDCLGMQLAMMETFLLFTNLSLQYECKLPPDQPTHSMRGHPGLTMPPESYKICAIER >AZ211455 42% to 2N1 GEPWVDLRRFSLPALRSFGFGKQSLVPQINLEARYLSEEIRNLRGEPTDLLTTFSKATANIICQLLFSQRYEYSDGEMSRVLERMNETL >AZ206702 93% to AZ159610 PFLLETPLYSEFRNLISSLKTLVADMVDEHGETLDDQHIRDIIDLYILEIRELIKRGDEIVFNETTVWRGIFDMISAGTGTTSTTLLWGILLMAAHPDAMEQV >AZ159610 6 aa diffs to AZ206702 (allele?) SLKTLVAYMVDEHGETLDDQHIRDIIDPYILEIREHKKRGDEIVFNETTVWPGIFDMIS 375 AGTGTTSTTLLWGILLMAAHPDAMEHV >AZ204199 5 aa diffs to AZ206702 EHAKTLDDQHIRDIIDLYILEIREQKKRGDEIVFDETTVWRGIFDMISAGTGTTSTTLL 217 WGILLMAAHPDAMEQV >AZ147012 N-term LVILVLVLWMVKSFVSKRYGKQYRLPPGPSALPIIGNLPVFMTGKAPYRVMKNLADKYGSVFSLKIGTTPFVVLNDVDSIR >AZ179521 39% to 2X2 FGVGKYSMEQRIINEAKVLCETIENNQERSFNPKGCITHSVSSIICGITFGQR 407 >AZ200345 32% to 2Y1 ESVIASQADILVEDIRKRGTFDPLLCLQSNVCSVICGVVFGKQYGLDNPRFTDLLETMYNALRAIEYAAVSSLVPGLHYLPGCSYQKFYACMDKLMRFFREEINAHDETLDPDS 91 CYP3 clan >CD305284 41% to CYP5A1 fugu (N-term) MEVELMGISMSLTWLLAMITLGFSVLYVAYECWSRTYWWRRGVPYEPSLPIIGNP LFTSKIPENFVEWNKKYGKVYGTYSFRDPVLVVGDPEML RHLLVKSFNSFHNRVSFPQIPEELAGMVSLLEGERWKEVRNVLTPSFSGA >CD304823 35% to 5A1 YDIWCRRYWIRHGISSPPSQPVLGNTYEW GERVYNFNRPILVISDLDA ARNILVKDFHHFYNRLNAPLANRPMDKALFFLKDARWKAVRNISSPTFSAS KMKLMSTLV NEKADRLVENIGREQQKHGFVECRELYGSYIMDSTTRCAFGLDVDSQGDPEHPFVAHAKK TFQVXXCLQPSDCACGTFPLAVPHISLL >AZ191886 C-helix 50% to 5A1 GSFDNALFLLRDAQWKRVHDIMTPTFTGKKMKMVF >AZ175862 51% to CYP5A fugu LFGAYIMDTIGLCAFGLNVDSQKNKDDPFVLNAKRFFSSLDFTSPAMIISML 413 >CD291340 CD319443 50% to 3A27 trout (C-term) RGGSKMKDFLQLMLNAAQENKSEKEKPQDEKVEGDLHALIEDQDNKSYFDLKKSKKTTLT KDEIYGQAIIFFLAGYATIHTTLGFVT YCLATNPEVQDKLIEEIDNETPTRDDVGYNSIAKMSYLDNVVCEILRLYPASVLVERQCNETHVCN GITIPKDSQVMFPVFAIHRDPALWPDPEKFDPERFTKE NREGRHPLAWMPFGAGPRNCIGMRFALMEIKMATVRLLQK >CD304734 46% to 3A49 fugu 51% to CD291340 LTFGLHVIPADTLDFFRDVNKKTIALRKSSSSGPN ??? SKRVDFLQLLLDA 161 QKQENIDKESKPEEEEEEDDDDIHADLDKHHDVQYHSRGLGKKATLTDNEVFAQGLIF 334 335 FTAGSETTTTLLGFIAYSLATNPEAQEKLIDEIDRVTPSRDSVGYKSVATMPYLDQVVCE 514 515 TLXIFP 532 >CD295691 70% to CD304734, 43% to CD291340 ARVRSDSSLGRLMANFRISMLIPAEVLDFFNDVTKKTINLRKEAVAGSNFKRVDFLQLLL DAQKQETVDKAVDHVEDDDENDIHDDLDKHHDVHYHTKTLGKRAPLTDEEVFAQVLIFFT AGAETTTTLLGFIFYALSMNPDIQEKLISEVDEVTPSRDSVGYSSIATMPYLDQVVCETL XLYPPAGISNRMXYETFVHXGLMIEKGN CYP4 clan (CYP4V5 like) >CD296197 54% to 4V7 N-term AZ191715 AZ198827 MEYGIVLPIILILVSVVVTFLLAKAIRIFVLISRFDGPPALP LVGNAHEFKSDQREFFVDMTTLMEEYRARSGGLLRMWLGPVPSLTLYKAKHVEVILNNSR HIKKGYLYKFLEPWLGLGLLTSWGQKWFHRRKMLTPTFHFS ILQSFMDVFNEQSMILVKKLEKFAEKSETVNIFPLVAYCVLDIIC >BG786093 57% to 4V5 like frag, 45% to 39 like seq 180 Ciona, like CYP26B DSADLVHDVASLATTHWHGVISVPMNWSVSYWSSSCKRAVEAKDKLLERI RDRLASQTDEGSFLTRAREAGFKNHAELEQHILPFVSALVPKAIASLLASFTLALCSENQ EDMQEKARESSDYLDWCLLETERLWPPVLGGRRLVREDFVLDGYKVPKGYAVIYVSSIAH RDPNVFKNPNSFDPTRWANKRTEKEKLLFCYGDGPRCCVGTFLMKNLIKKVSQYLVGHYN WTLXDQEEDLDYN >CD335085 short piece like CYP2 or CYP4V ETLRGYPGVPANNRGWGKDVTIGGYHIPKGS HDGVSYVRGRD PEIYPEPDTFLPXR >CD311709 56% to Cs4v5b 41% to CD291340 VQTRLHEELDEVFG XXXXXXXXXXX LQKLQYLNCVSKETLRLCPSVPMIGRDLEEDC XXXXXX VPKGTLVVLGIYALHRDPEQFPDPEKFDPDRFLLENSTKRHPYAYVPFSAGPRNCIGQKFAM X EDKVILANLMRKFSV >AZ147906, AZ176297 75% to CD311709 64% to 4V5 PNSERFDPDRFLPVNAEERHPYAYVPFSAGPRNCIGK >CD320455 41% to CYP46 fugu 38% to 4V5 HASEPPVSGASRELASDVQSCGYVIPKGASVLFLSYLTSRLEEYFDDPLLFNPDRFIPTDETPRHFFAYFPFAIGQRNCIGQQLALIESKVILAKLLQSFDFRLEQSQRHIIVSQVTNKP IDGCKNYISLRD* >AZ198877 62% to CD320455 GILVCFFAWFGFPMGPRNCLG >AZ174957 57% to 4V5 56% to CD320455 FPITTRPRHLYAYFPFSMGQRSCIGQQFALVSISIIFALS >AZ199572 37% to 4V5 P*VWSDDHMPFRPSRXDGQNVEGGDPFVSIPFSAGARNCIAQQFALQEIQVAAIRIYDKFGFTLVRDSTPVFRIVSVPEDXILLGIHPRRET* >AZ203676 AZ170842 AZ170778 I-helix 58% to CYP46 FCISGQETTSNLLAFTILQLGRHPDVAKK 262     CDabc    2 3 _ `   K L , - . 7 8 9 o p L M   H I o p q EFZh|#5B*\phh|#B*CJOJQJaJphZDbc   3 `  L - . 8 9 p M ed] #  I p q F[z{0 Sed] #Z[yz{/0  RSwx~RS~BCpqr~89OP~%&Z[~012[\~"#89:abfh|#B*CJOJQJaJph^SxSCqr9P&[12\#9ed] #9:b<Ujk H 2oed] #;<TUfijk  GHf 12fnoUVAB\]^/01cd OPh|#B*CJOJQJaJph^VB]^01d P9ved] #89uv  V W X !!!!!M!N!!!!!!!!!""D"E"{"|"}""""""""9#:#[#\#]#v#w######$$$$$^$_$c$$$$$$$$N%O%c%%%%%%%%%%%&D&E&h|#B*CJOJQJaJph^ W X !!!N!!!!!"E"|"}"""":#\#]#w###$ed] #$$$_$$$$$O%%%%%%&E&&&&&:';'c'''''''%(ed] #E&c&&&&&&&&9':';'b'c'''''''''''$(%(`(a(~(((((((())%)I)J)P)Q)R)v)w))))))**%*I*J*K*T*U********%+4+5+6+j+k++++++,,,,6,7,,,,,, - --h|#CJOJQJaJh|#B*CJOJQJaJphZ%(a(((((()J)Q)R)w))))*J*K*U*****5+6+k++++,ed] #,,7,,,, -'-(-I-------.N.O.d..... /E/m////ed] #-&-'-(-H-I------------...M.N.O.c.d....... / //D/E/l/m//////////00&0'0c0d000000000000111H1I11111111 2 2425262`2a2222h|#5B*\phh|#CJOJQJaJh|#B*CJOJQJaJphU///0'0d000000011I1111 25262a2222'36373b33ed] #22222&3'3536373a3b3333344546474N4O4P4}4~44444455=5>5?555555555666r6s666666666666667777*7+7K7L7R7S7777777777777"8#8S88h|#5B*\phh|#CJOJQJaJh|#B*CJOJQJaJphU3346474O4P4~4445>5?555566s6666666677+7L7S7ed] #S77777777#88888889*9+9@99999999999gd~mLed] #888888888899)9*9+9?9@9S999999999999999999999::::::::: : : : : ::h~mLjh|#Uh|#h|#B*CJOJQJaJph49999::::::::: : : : : ::ed] #gd~mL01h/R / =!"#$% x666666666vvvvvvvvv666666>6666666666666666666666666666666666666666666666666hH66666666666666666666666666666666666666666666666666666666666666666p62&6FVfv2(&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@66666_HmH nH sH tH H`H Normal CJOJQJ_HaJmH sH tH DA D Default Paragraph FontRiR 0 Table Normal4 l4a (k ( 0No List D/D msonormaldd[$\$OJQJ4@4 ~mL0Header  H$B/B ~mL0 Header CharCJOJPJQJaJ4 @"4 ~mL0Footer  H$B/1B ~mL0 Footer CharCJOJPJQJaJPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vj\{cp/IDg6wZ0s=Dĵw %;r,qlEآyDQ"Q,=c8B,!gxMD&铁M./SAe^QשF½|SˌDإbj|E7C<bʼNpr8fnߧFrI.{1fVԅ$21(t}kJV1/ ÚQL×07#]fVIhcMZ6/Hߏ bW`Gv Ts'BCt!LQ#JxݴyJ] C:= ċ(tRQ;^e1/-/A_Y)^6(p[_&N}njzb\->;nVb*.7p]M|MMM# ud9c47=iV7̪~㦓ødfÕ 5j z'^9J{rJЃ3Ax| FU9…i3Q/B)LʾRPx)04N O'> agYeHj*kblC=hPW!alfpX OAXl:XVZbr Zy4Sw3?WӊhPxzSq]y 28f ZE&-28:!$&),.1 S9$%(,/3S79: "#%'(*+-/02@ @H 0(  0(  b S  ?C"] #~mL|#11@2@UnknownG.[x Times New Roman5^Symbol3. *Cx Arial7Courier?Z PTimesTimesC.,*{$ Calibri Light7.*{$ CalibriA$BCambria Math"1h''t*Zt*Z%011B@P $P'~mL2!xx? NormalC64 sequence fragments from purple sea urchin + 3 complete sequencesStephen NelsonMicrosoft Office User Oh+'0 0 P\ |  'D64 sequence fragments from purple sea urchin + 3 complete sequencesStephen NelsonNormalMicrosoft Office User2Microsoft Office Word@F#@zVP@zVPt* ՜.+,00 hp  'PrivateZ1 D64 sequence fragments from purple sea urchin + 3 complete sequences Title  !"#$%&'()*+,-./012356789:;<=>?@ABCEFGHIJKMNOPQRSVRoot Entry F@}PX1Table4WordDocument2fSummaryInformation(DDocumentSummaryInformation8LCompObjr  F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q