>CYP1A NM_131879 AF210727 AY398333 AB078927 AF057713

MALTILPILGPISVSESLVAIITICLVYLLMRLNRTKIPDGLQK LPGPKPLPIIGNVLEIGNNPHLSLTAMSKCYGPVFQIQIGMRPVVVLSGNDVIRQALL KQGEEFSGRPELYSTKFISDGKSLAFSTDQVGVWRARRKLALNALRTFSTVQGKSPKY SCALEEHISNEGLYLVQRLHSVMKADGSFDPFRHIVVSVANVICGICFGRRHSHDDDE LVRLVNMSDEFGKIVGSGNPADFIPFLRILPSTTMKKFLDINERFSKFMKRLVMEHYD TFDKDNIRDITDSLINHCEDRKLDENSNLQVSDEKIVGIVNDLFGAGFDTISTALSWA VVYLVHYPEVQERLQRELDEKIGKDRTPLLSDRANLPLLESFILEIFRHSSFLPFTIP HCTSKDTSLNGYFIPKDTCVFVNQWQVNHDPELWKDPSSFIPDRFLTADGTELNKLEG EKVLVFGLGKRRCIGESIGRAEVFLFLAILLQRLKFTGMPGEMLDMTPEYGLTMKHKR

CLLRVTPQPGF

 

>CYP1B AJ249074

MMDVLLALRDLLQLSTRSVLLSLMVCLMLMFRRRQLVPGPFSWPVIGNAAQLGNTP HFYLSRMAQKYGDVFQIKLGSRNVVVLNGDAIKEALVKKATDFAGRPDFASFRFVSNGKS MAFGNYTPWWKLHRKVAQSTVRNFSTANIQTKQTFEKHIVSEIGELIRLFLNKSREQQFF QPHRYLVVSVANTMSAVCFGNRYAYDDAEFQQVVGRNDQFTKTVGAGSMVDVMPWMQYFP NPIRTLFDQFKELNKEFCAFIELKVSEHRKTISPSHVRDMTDAFIVALDKGLSGGSGVSL DKEFVPPTISDIF

GASQDTLSTALQWIILLLVR YPEIQKRLQEDVDRVVDRSRLPTIADQPHLPYLMAFIYEVMRFTSFTPLTIPHS TTKDTSINGYPIPKDTVIFVNQWSLNHDPTKWDQPEVFNPQRFLDEDGSLNKDLTTNVLI FSLGKRRCIGEDVSKIQLFLFTSVLVHQCSFKAESTPNMDYEYGLTLKPKPFKVSVTARD SSDLLDSLVGTSQTPTEKR

 

>CYP1C1 NA17619 79% to CYP1C2

MEAEFGLKSSSIMREWSGQ VQPALIASFIILFFLEACLWVRNLTFKKRLPGPFAWPLVGNAMQLGQMPHITFSKLAKKY GNVYQIRLGCSDIVVLNGDAAIRKALVQHSTEFAGRPNFVSFQMISGGRSLTFTNYSKQW KTHRKVAQSTLRAFSMANSQTRKTFEQHVVGEAMDLVQKFLRLSADGRHFNPAHEATVA AANVICALCFGKRYGHDDPEFRTLLGRVNKFGETVGAGSLVDVMPWLQS FPNPVRSVYQNFKTINKEFFNYVKDKVLQHRDTYDPDVTRDMSDAIIGVIEHGKESTLT KDFVESTVTDLIGAGQDTVSTAMQWMLLLLVKYPSIQSKLQEQIDKVVGRDRLPSIED

RCNLAYLDAF

IYETMRFTSFVPVTIPHSTTSDVTIEGLHIPKDTVVFINQWSVNHDPQKWSDPHIFNPSR FLDENGALNKDLTSSVMIFSTGKRRCIGEQIAKVEVFLFSAILLHQCKFERDPSQDLSMD CSYGLALKPLHYTISAKLRGKLFGLVSPA

 

>CYP1C2 NA4026

MAQSDSEFSILKEWSGQIQPALIASFIILCCLEACFWVRNITLKKKRL PGPFAWPLVGNAMQLGQMPHITFSKLAKKYGNVYQIRLGSSDIVVLNGESAIRSALLQHS TEFAGRPNFVSFQYVSGGTSMTFASYSKQWKMHRKIAQSTIRAFSSANSQTKKSFEKHIV AEAVDLVETFLKIQHFNPSHELTVAAANIICALCFGKRYGHDDLEFRTLLGNVNKF SETVGAGSLVDVMPWLQTFPNPIRSIFQSFKDLNSDFFSFVKGKVVEHRLSYDPEVIRDM SDAFIGVMDHADEETGLTEAHTEGTVSDLIGAGLDTVSTALNWMLLLLVKYPSIQSKL QEQIDKVVGRDRLPSIEDRCNLAYLDAFIYETMRFTSFVPVTIPHSTTSDVTIEGLHIPK DTVVFINQWSVNHDPQKWSDPHIFNPSRFLDENGALDKDLTNSVMIFSIGRRRCIGDQIA KVEVFLISAILIHQLTFESDPSQDLTLNCSYGLTLKPFDYKISAKPRGSIVN*

 

>CYP1D1 Danio rerio (zebrafish) GenEMBL NM_001007310 5 introns

MNLENISHTATSEVTLILCAFALLLLALHGRRRAPGVPVPPGPRPWPIVG NFLQMEEQVHLSLTNLRVQYGDVFQVKMGSLVVVVLSGYTTIKEALVRQGDA FAGRPDLYTFSAVANGTSMTFSEKYGEAWVLHKKICKNALRTFSQTEPKDSNASCLLE ERICVEAIDMVETLKAQGEEFGDSGIDPVQLLVTSVANVVCTLCFGKRYSHNDKEFLT IVHINNEVLRLFAAGNLADFFPIFRYLPSPSLRKMVEFINRMNNFMERNIMEHLVNFDT

NCIRDITDALIAMCEDRQEDKESAVLSNSQIVHSVIDIFGA GFDTIITGLQWSLLYLIKFPNIQDKIVQEI DNQVGMDRLPQFKDRPNMPYTEAFINEVFRHASYMPFTIPHC TTENITLNGYFIPKDTCVFINQYQVNHDI EIWDDPESFRPERFLTLSGHLNKSLTEKVMIFGMGIRRCLGDNIARLEM FVFLTTLLHRLHIENVPGQELDLSSTFGLTMKPRPYRIKIIPRN*

 

>CYP2K6 AF283813

MALIEAFLLQGSPTGTILGALLLFLVIYLFSSSSSSQDKEKYPPGPKPLPLLGNLHILDLKKTYLSLLE LSKKYGPIYTVYLGPKKVVILSGYKIVKEALVNLSEEFGDRDISPIFHDFNRGY GIAFSNGENWREMRRFALSTLRDFGMGRKRSEELIIEEIKYVKEEFEKFX GNPFETKLPLALAISNIIASIVFSVRFEYSNTKLHRMVGRAYENMKLTGSPSVQ IYNMFPWLRPIVANRNQIVKNLRDTFKQNEELINGVMKTLDPFNPRGIVDSFLIRQQKDE ESGKTDSLYNSNNLYCTVNNLFGAGTDTTVTTLRWGLLLMAKYPEIQ

AKVQDEIERVIGGRQPVVEDRKNLPYTDAVIHEIQRFADISPIGAPRQTTCDVHLNGYFIKK GTPVFPLLVSVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGA GRRVCIGESLARMELFLFFTSLLQYFRFTPPPGVSEDDLDLTPVVGFTLNPKPHQLCAVKRS

 

>CYP2K7 AF487990

MALVGALLPGLSFTVGMVVAFLLLFLVISYFSSSKDQGKYPPGPKPLPLLGNLHILDLKNTYMSLWK LSKQYGPVYTVHMGPRTVVVLSGYKAVKEALVNLSEEFGERDISPIFQDFNEGY GIVFSNGENWKEMRRFALSNLRDFGMGKKRSEELITEEIKYLKEEIERFR GKPFETKLPLAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQ LYNMFPWLRLFVINQKRVVDNVQESFKQIGEIVNGLKKTLNPQSPRGIADKFLIQQQK DKESGKTDSLYNSNNFLTTINNLFGAGIDTTVTTLRWGLLLIAKYPEIQ AKVHDEIDSVIGERQPVPDDRKNLPYTDAVIHEIQRFADILPIGLLRQTSCDVHLNGYLIKK GTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGA GRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKLCAVKRF

 

>CYP2K8

MAVMETLLMPVSITGVLLSAVLLFLVVYLISISSSSPEDPPGPKPLPLLGNLHTLDLKNLHVSLWE LSKKYGPVFKVHLGRKKVVVLAGYKTVKQALVNQAEEFGERDITPIFQDCNQGQ GIVFANGERWRTMRRFALSTLRDFGMGKKLSEEKIVDETRYLREVFMKFE GQPFDTTQPVNYAVSNIISAIVYGKRFEYEDPAFQDMVNKANMNIRMIGSAVIQ IYNMCPFLGPWIKTWRQLMKNMESTRRQIQTLADVLQETLNPLDCRGLIDSFLIRKQNIQ

ETGEKDSSFNDQNLLITVSNLFAAGTDTTGTTLRWGLMLMAKYPQIQ DRVQEEIDQVLGGREPVAEDRKNLPYTDAVIHETQRLANILPLNLPHKTSCDVTFNGYFIKK GTCVLPLLTSVLRDETEWETPDTFNPQHFLDEKGQLIKRDAFMPFSA GRRACLGESLARMELFLFFTSLLQYFRFSPPPGASEDELDLTPVVGLTLNPSPHKLCAVIR

 

>CYP2K16

MAFLDALLHVSSTGTLICFLLLLLVAYLLFLRSQSDENEPPGPKPLPLLGNLLMLDVNKPHLSLCE MAKQFGPVFKVYFGPKKVVVLAGYKAVKQALVNYAEAFGDREIMPLFHDFTKGH GIIFANGESWREMRRFALTNLRDFGMGKKKIEEKIIEETCHLREEFEKFX GKPFETAQLMNYAASSVISSIVYGRRFEYTDPQLRTMVDRANESVRLSGSASVQ LYNMFPFLGPLLKNWRQLMKNLHLDIEEISELVNGLHQTLNHQDLRGFVDSFLVRKQX DQDSGEKDSHFHEQNLIYTVGNLFVAGTDTTSTTLRWSLLLMAKYPHIQ DRVQEEIDQVIGGRQPVSEDRKNLPYTDAVIHETQRLANIVPMSIPHMTSSDITFNGYFIKK GTCIFPLLTSVLWDEDEWETPHIFNPNHFLDEQGRFVKRDAFMPFSA GRRICLGESLARMELFLFFTSLLQYFRFTPPPGVSEDELELTPAVGFTLNPIAHKLCAVKR

 

>CYP2K17

MAVVESLLHFSSAGTLLGTLLLLLVFYRLSRDSEFQKKRKDPPGPKPIPLLGNLLTLDLSRPFDSLCE LSKTYGNVYQVFLGPKKVVVLIGHKTVKEALVNYADEFGERDITPIFRXXXXXX GILFSNGESWKEMRRFAISNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPRFTEMVDRANENIRVSGSVSMX LYNIFPWLGLFLNSKRTVVRNMLKNRAEFMKLITGLQETLNIHDRRGFVDSFLIRKQX XXXXGKKDSYFHAENLLMTVGNLFAAGTDTTGTTLRWGLMLMAKYPQIQ XRVQEEIDRVIGGRQPVVEDRKKLPYTDAVIHEIQRLANIVPMNLPHVTSCDVTFNGYFIKK GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSA GRRVCLGESLARMELFLFFASLLQSYRFTTPPGVSEDELDLKGTVGVTLNPSPHKLCAIKRF

 

>CYP2K18

MAVVESLLQFASTGTLLGALLLFLVLYLVSSGSESQKEGKEPPGPKPLPLVGNLLTLDLTRPFDT FFKLSKTYGNVFQVYLGPEKAVVLVGYKTVKEALVNYAEEFGDREIGPGFSIMNDEH GILFSNGENWKEMRRFALSNLADFGMGKRRSEEK GILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKF GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMX LYDIFPWLGPFLKNKRIIVENIIQSRVQMTKLITALLETLNPNDPRGFVDSFLIRKXX XQKSGKKDSYFHEENLMMTVTNLFIAGTDTTGTTLRWGLMLMAKYPHIQ XRVQEEIDRVIGGRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVRRDAFMPFSA GRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR

 

>CYP2K19

MAVVESLLQFASTGTLLAALLLFLVLYLVSSGSQKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFE LSKTYGNVFQVFLGPRKTVVLVGYKTVKEALVNYAEQFGDREIGPGFRIMNDXX GILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX GKPFDTTQPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSVSMX XHEMFPWVGPFLKSKRIIVENIIQSRAQMTKLITALLETLNPNDPRGFVDSFLTRKXX XQKSGKKDSYFHEENLIMTVTNLFVAGTDTTGTTLRWGLMLMAKYPQIQ XRVQEEIDRVIGGRQPVVEDRKKLPYTDAVIHEIQRLANIVPLSLPHKTTSDITFNGYFIKK GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFIPFSA GRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR

 

>CYP2K20

MAVVESLLQFASTSALLGALLLLLVLYLASSGSTSQKEGKEPPGPKPLPLVGNLLTLDLTRSFDTFFE LSKTYGNIFQVFLGHRKTVVLVGYKTVKEALVNYAEVFGDREIGPGFKXXXXX GILFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX GKPFDTTQPVNYAVSNIISSIVYGSRFEYIDPRFTEMVARANENVRVGGSFSMX IYNIFPWLGPFLKNRAVVVKNITQNRAEKKKLITALLETLNPHDPRGFVDSFLIHKXX XQKSGKKDSYFHEENLMLTVANLFAAGTDTTGTTLRWGLMLMAKYPHIQ DRVQEEIDRVIGGRQPVVDDRKKLPYTDAVIHEIQRLANIVPLSLPHRTTSDITFNGYFIKK GTTVVPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSA GRRVCLGESLARMELFLFFTSLLQSYRFTTPPGVSEDALDLKGIVGITLNPSPHKLCAIRR

 

>CYP2K21

MAVVESLLQFASTGTLLGALLLFLVLYLVSSGSGSQKEGKEPPGPKPLPLLGNLLTLDLTRAFDTFFE LSKTYGNIFQVYLGPKKTVVLVGYKTVKEALVNHAEAFGDREIGPSFRIMNDXX GIVFSNGENWKEMRRFALSNLRDFGMGKRGSEEKIIEEIHHLKGEFDKFX GKPFDTTEPVNYAVSNIISSIVYGSRFEYTDPQFTEMVDRANENVRVGGSISMX LYNMFPWLGPFLKNKRIVVRNIIQSRAQMTKLITALLETLNPNDPRGFVDSFLIHKXX XQKSGKKNSYFHNENLMMNVANLFVAGTDTTGTTLRWGLMLMAKYPQIQ XRVQEEIDRVIGGRQPAVEDRKKLPYTDAVIHEIQRFANIVPLNLPHTTSCDITFNGYFIKK GTTVIPLLTSVLKDESEWEKPNSFYPEHFLDEKGQFVKRDAFMPFSA GRRICLGESLARMELFLFFTSLLQSYRFTTPPGVSEDELDLKGIVGITLNPSPHKLCAIRR

 

>CYP2K21-de1

MAAVETLLQFASTGSLLSALLLLLVWYLVSSESTYQKKGKEPPGPKPLPLLGNLLT

 

>CYP2K22

MALVAALLPGLGFTVSTILAFLLLFLVISYFFSSKDKGKYPPGPKPLPVLGNLHILDLKNTYMSLWK LSKQYGPVYTVHMGPRTVVVLSGYKVVKEALVNLSEEFGERDISPIFQDFNEGY GIVFSNGENWKEMRRFALSNLRDFGMGKKRSEELITEEIKYLKEEIERFX GKPFETKLPLAMAISNVIALIVYSIRFEYNSPKFHRAIVRANENAKLVGSPSVQ LYNMFPWLRLFVANQKRVVDNVQESFKQIGEIVNGLKKTLNPQSPRGIVDKFLIQQQK AKVHDEIDSVIGERQPVPDDRKNLPYTDAVIHEIQRFADILPIGLLRQTSCDVHLNGYLIKK GTSVFPLIASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGA GRRLCIGESLARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLSPMPHKLCAVKRF

 

>CYP2K31 XM_001334054.1 86% to 2K7 Zv8:3:6891380-6890715

MALVGALLPGLSFTVGMVVAVLLLFLFISFFSSSQDEGKYPPGP KPLPLLGNLHILDLKNTYMSLWKLSKTYGPIYTVHMGPRKVVVLSGYKTVKEALVNLS EEFGDRDISPIFHDFNQGYGIVFSNGENWKEMRRFALSNLRDFGMGRKRSEELIIEEI KQLKEEFEKFRGKPFETKMPIAMAIANIIALIVYSIRFEYTNTKLHCMIGRAYENARL TGSPSVQLYNMFPWLRPFVANQKRIINNVKEAFKQSGEIMNGLKNTLNPQDPRGIADK FLIRQQMDEDSGKTDTYYNSNNLLSTINNLFGAGTDTTVTTLRWGLLIMAKNPEIQAK VQDEIKRVIGDRQPVPDDRKNLPYTDAVIHEVQRFADVLPIGSPHQTTCDVHLNGYLI KKGTSVCPLLASVLRDENEWETPDSFNPKHFLNKQGQFVKKDAFMPFGAGRRLCIGES LARMELFLFFTSLLQHFCFTPPPGVSEDELDLTPVVGFTLNPIPHKLCAVKRS

 

>CYP2N13 ctg24224.a Z35723-a834b06.q1c zfishC-a2756d10.q1c 55% to 2N2

MAYTAILETLDVKGILLFMVAFLLVADYLKNRNPPKYPPSPFSVPLLGNIFNVDSKEPHLYLTK LGHAYNNIFSLRLGSDKTVFITGYKMVKEALVTQAENFVDRPNSPVLARVYSGNA GLFFSNGEMWKKQRRFALSTLRNFGLGKKTMELAICEESRFLLEEIDEQK GAAFDPTILLYNAVSNIICQMVFGQRFDYADHQFKTMLKYISKSIQLEGSVWGQ IYEAFPAIMKHLPGPHNDIFSNYDLLKSFVHEVIVKHKAKLDPSEPRDYIDTFLIEMKE KPHERVNGFEEPNLVACVLDLFLAGTESTSNTLCWGLIYLIMYPDVQ EKVQEEIDRVIGNSREPSIADKPNMPYTEAVIHEIMRFGDVIPLNGLRVAARDTTLGECFIPK GTTVLPILHSVLFDENEWETPYKFNPGHFLDKEGKFVRRDAFMPFSA GKRVCLGEQIARIELFLFFVSLFRKFRFSATEGEKLNMDGVIGITRTPHPFKICATAR

 

>CYP2P6 ctg24224.g 77% TO 2p9

MDLLHIYEWIDIKAVLFFACVFLLLSNYIQNKTPKNFPPGPWPLPIIGNLYHIDFNKIHLEVEK LSEKYGSVVSVHLFGQRTVILNGYKQVKEVYIQQGDNVADRPELPMIHDIAGDN GLVAPSGYKWKQQRRFALSTLRNFGLGKKSLEPSINLECHYLNEAISNEN GRPFDPHLLLNNAISNVICVLVFGNRFDYSDHHFQTLLNNINEAMYLDGTIWAQ LYNSHPRIMRLLPGPHKKNITLWNKVIDFARERVKEHRVDYDPSNPRDYVDCFLAEMEK LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLSWSLLYMIKYPEIQ AKVQEEIDRVIGSSRQPSVSDRDNMPYTNAVIHEIQRFGNIAALNLPRAAVKDIQVGKYLIPK GTIVIGNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS GKRVCLGEQLARMELFLFFTSLLQHFTFSSPAGVEPSFNYKLGTTRAPKPFKLCAVSR

 

>CYP2P7 ctg24224.h 81% to 2p9

MDVLQFYKWLDIKTVLVFLVVFLFLSDYIRNKSPKNFPPGPWSLPFIGHIHHIEHKKVHLQFLK FAEKYGKIFSIRLFGPRIVVLDGYKLVKEVYLQQGDNLADRPILPMFYDITEDK GLIGSNGYKWKHQRRFALSTFRTFGLGKKSLEPSILLECSCLNDAFSNEQ XPFDPRLLLNNAVSNVICALVFSNRFDYSDHHFQTLLKHINEVLYLEGTVWAQ LYNFFPWLMRRLPGPHQKIFVLLNKVIDFVREKVNEHRVDYDPSNPRDYIDCFLAEMEK LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYIIKYPEIQ AKVQQEIDAVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIVPLNVFRITVEDTQIGEYSIPK GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGGTHSPQPYKLCAVPR

 

>CYP2P8 ctg24224.i 90% TO 2p9

MDLWYLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHLQFTK FAERYGNIFSFRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEIIGDK GLILSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINVECGFLNEAISNEQ GRPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKNISEAVYLEGSICNQ LYNMFPWLMERLPGPHKTIITLWRKVTDFVREKVNEHRVDYDPSNPRDYIDCFLTEMEK LKDDTAAGFDVENLCICSLDLFVAGTETTSTTLYWGLLYMIKYPEIQ AKVQEEIDAVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIAPINLARSTSEDTQIGNYSIPK GTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKMGGTHCPKPFKLCAVPR

 

>CYP2P8-de7,8 ctg24224.j EXONS 7,8

PSVSDRDNMPYTNSVIHEIQSIGNIGPLNVFGITVK

GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS

 

>CYP2P9_ctg24224.k 98% (7 AA DIFFS) TO 2p9

MDLWYLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHLQFTK FAERYGNIFSLRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEIIGDK GIVLSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINLECGFLNEAISNEQ GQPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKHINEAIYLEGGICAQ LYNMFPWLMQRLPGSHKKVITLWKKVIDFIRQKVNEHKVDHDPLNPRDYIDCFLAEMEK LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPVIQ

AKVQEEIDRVVGGSRHPSVSDRDNMPYTNAVIHEIQRMGNIIPINVTRTTSEDIRIGKYSVPK GTMVTSNLTSVLFDESEWETPHSFNPGHFLNAEGKFRRRDAFLPFSL

GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGATHCPQPYKLCAVPR

 

>CYP2P9_BC056816, NM_200620 61% to CYP2P3

MDLWDLYEWIDIKSILIFLCVFLLLGDYIKNKAPKNFPPGPWSLPIIGDLHHIDNSKIHLQFTK FAERYGNIFSLRLFGPRIVVLNGYNLVKEVYIKQGDNLADRPVLPLFYEIIGDK GIVLSSGYKWKHQRRFALSTLRNFGLGKKSLEPSINLECGFLNEAISNEQ GQPFDPRLLLNNAVSNVICVLVFGNRFDYSDHHFQTLLKHINEAIYLEGGICAQ LYNMFPWLMQRLPGSHKKVITLWKKVIDFIRQKVNEHRVDHDPLNPRDYIDCFLAEMDK LKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPGIQ AKVQEEIDRVVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIIPINVTRTTSEDIRIGKYSVPK GTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSL GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYKLGATHCPQPYQLCAVPR

 

>CYP2P10_BC049521, NM_201511 84% to CYP2p9 zfishG-a2632g08.q1c

MDMFYFYEWVDIKSILIFLCVFLLLSDYIKNKAPKNFPPGPWSL PFIGDLHHIDPNKIHLQFTEFAEKYGKIFSFRLFGSRIVVLNGYNLVKEVYTQQGDNL ADRPTLPITSAIIGDNRGLVASSGYKWKHQRRFALTTLRNFGLGKKNLELSINFECGF LNEAISNEQGRPFNPRLLLNNAVSNVICVLVFGNRFEYSDHHFQNLLNKINESVYLEG SIFVHLYNMFPWLMQLLPGPHKKLITLWQRVTDFVREKVNEHRVDYDPSSLRDYIDCF LAEMEKHKDDTAAGFDVENLCMCTLDLFVAGTETTSTTLYWGLLYMIKYPEIQAKVQQ EIDAVVGSSRQPSGSDRDNMPYTNAVIHEIQRMGNIIPLNVVRTTSEDTRIEKYSIPK GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSL GKRVCLGEQLA RMELFLFFSSVLQRFTFSPPAGVEPSLDFKMGFTRCPKPYKLCAVPR

 

>CYP2P10_ctg24224.l 3 AA DIFFS TO 2P10

MDMFYFYEWVDIKSILIFLCVFLLLSDYIKNKAPKNFPPGPWSLPFIGDLHHIDPNKIHLQFTE FAEKYGKIFSFRLFGSRIVVLNGYNLVKEVYTQQGDNLADRPTLPITSAIIGDNR GLVASSGYKWKHQRRFALTTLRNFGLGKKNLELSINFECGFLNEAISNEQ GRPFNPRLLLNNAVSNVICVLVFGNRFEYSDHHFQNLLNKINESVYLEGSIFVH LYNMFPWLMQLLPGPHKKLITLWQRVTDFVREKVNEHRADYDQSSLRDYIDCFLAEMEK HKDDTAAGFDVENLCMCTLDLFVAGTETTSTTLYWGLLYMIKYPEIQ

AKVQQEIDAVVGSSRQPSGSDRDNMPYTNAVIHEIQRMGNIIPLNVVRTTSEDTRIEKYSIPK GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSL

GKRVCLGEQLARMELFLFFTSVLQRFTFSPPAGVEPSLDFKMGFTRCPKPYKLCAVPR

 

>CYP2P10-de9 ctg24224.m 3 AA DIFFS TO 2P10

MELFLFFSSLLYF

FTFSLPADVKPSLGYKMGAHTVP

 

>CYP2P14

MDMLHFYEWIDIKSILIFVCVFLLLSDFIKNKTPKNFPPGPWSLPIIGDIHHIDPSKLHLQLSE FAEKYGKIFSLRLFGPRIVVLNGYNLVKEVYTQEGDNLADRAILPLFHDIIGDKG GLVASSGYKWKQQRRFALSTLRNFGLGKKNLEPSINLESGFLNEAISNEQ GQPFDPRLLLNNAVSNVICALVFGNRFDYSDHKFQTLLKNINETVHLEGGICAQ

LYNMLPWLMRLLPGPHKRIIALWGKLIEFVGEKVNEHKVDHDPLNPRDYIDCFLDEMEK

XKDDTAAGFDVENLCICTLDLFVAGTETTSTTLYWGLLYMMKYPEIQ

AKVQQEIDVIVGGSRQPSVSDRDNMPYTNAVIHEIQRMGNIIPINLARTTSEDTQIEKYSIPK GTMVTSNLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFSL GKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEPSLDYNLGATHCPQPYKLCAVP

 

>CYP2P15P PSEUDOGENE ctg24224.f 67% to 2P7 chr20 25198264-25201490

MDLLHLYEWIDIKTILLFTLVFLLLGDYIKNKLPKTFHP

PGPWSLPIIGDVHINHKKIPLQLEK FAEKYGNVLSIQILGIRFVVLIGYKTVKEFYAQGDSLTDRPILPIFYDIFGDK

ANVQEEIDGVVGGSLSDRDNMPHTIAAIHKLHKL*VIRMGNIVPLNLACVTSKETQTGKYSIPK GTLVIGSLTSVLFDESEWETPHSFNPGHFLDAEGKFRRRDAFLPFS

GKRRCPGEQLAFSLHVGVEPSFDYKVG

TTGCPLPHNLCAVPQ

 

>CYP2R1 AL954331.8 zfishG-a628h11.q1cz 77% to 2R1

MISIKRLTSPLSLSW

EQTLICLLGLFTTLLILLVIRQLVKQRRPRGFPPGPTPLPIIGNM

LSLATEPHVYMKRQSDIHGQ

IFSLDLGGIPTVILNGYDAIKECLYHQSEVFADRPSLPLFQKMTK

KLAVNCFRYFGTGQRMFERISEECLYFLDAIDQHQGKPFNPKHLVTNAVSNITNLIIFG QRFTYDDGDFQHMIEIFSENVELAASSWAFLYNAFPWMEYLPFGKHQRLFRNANEVYKFL LQIIRRFSQGRVPQSPQHYIDAYLDEMEQSTPDKATSFSQDNLIFSVGELIIAGTETTTN CLRWAMLYMALYPRIQ

EKVQMEIDSVLNGRQPAFED

RQRMPYVEAVLHEVLRLCNIVPLGIFRATSQDAVVRGYTIPKGTMVITNLYSVHFDEKYW SDPSIFCPERFLDCNGKFIRHEAFLPFSI

GKRHCLGEQLARLEMFLFFTTLLQRFHLQFSEGFIPSLSAKLGMTLQPQPYSICAIRRQQ*

 

>CYP2U1 ctg13442 63% to 2U1 fugu 57% to 2U1 human zfishG-a1404f04.q1c

MDVSAGLLLEYVFSP ANIAGLTALVLVFYVLQEYQWHQTYANIPPGPKPWPIVGNFGGFLVPPLIIKRFXKNSQE

FAKVVSNPLSPQAGLIEMSKLYGNIFSIFVGPQLMVVLTGYDAVRDAMLNHTETFSDRPH

IPLVTIITKRK

GIVFAPYGPLWRTNRRFCHSTLRSFGFGRMSLEPCIHEGLAIIKTELQSLIETAGPSGID

LTPLISNAVSNIISLMSLGQRFHHEDKEFRNMRDLMSHGLEISVNTSILLVNVFPWLYYL

PFGVFKELRRAELDITAFLKRIIARHRATLDPENPRDFIDMYLVEMLAKQKEGSSEENLF

SEDDLFYIIGDLFIAGTDTTTNSMLWSILYMSLYPDVQ

EKVQKEIDAVVGSERVPSLTDKSSLPYTEATIMEVIRMTVVVPLSIPHMASETT

EFRGFTIPKGTVIIPNLWSVHRDPTVWENPDDFNPSRFLDDQGKILRKDCFIPFGL GRRVCMGEQLAKMELFLMFTSLMQTFTFRFPEGATAPSMHGRFGLTLAPCPFTVCVKTR*

 

>CYP2U1-de1 ctg13442 Duplicate exon 1 partial

QLMVVLTGYDAVRDAMLNHTETFSDRPHIPLVTIITKRKG

 

>CYP2V1 AB026158 zfishC-a1007a08.p1c zfishK-a1019e01.q1c

MALENILLHLNSKVWTDAGTILLLFILFLLVSVKLRNRNKPTKT FLLGPTPLPFIGNVFNLDTSQPHICLTKMSDHYGNIFSLRLGSLNTVVVNTYSMVKKV LNDQGNSFMYRPSNDITERILSKCQGLTFNNGYSWKQHRRFTLSTLKFFGVGKRSLEF IIMEEYKFLHQSILDTNGLPFNPHYIINNGVSNIICSMVFGRRFEYTDQRFLNMLSLI SKALKLQTSVFIQLYAAFPRLMDLLPGPHKELFSCFHQVRAFIKEEVDKHRADWDPSS PRDFIDCYLTEIEKMKDDLEAGFHDEGLQYAVLDLFVAGTETTSTTLLWAFVYMMKYQ KSKKVQAEIDKVVGRYRRPSMDDRPCMPYTDAVIHEIQRMGNVVPLSVPRMTNEDTLL EGLFHSLRVLQIIPNLTSVLFDQTKWKTQHSFDPQNFLNAQGKLKSLKLLSPFSLGKR SCPGESLARMELFLFFTSFLQSFSLSAPDETQTSLDFKCGMTLSPKPFKICFTPR

 

>CYP2V1 ctg24224.e SOME DIFFERENCES WITH AB026158 AT INTRON BOUNDARIES

MALENILLHLNSKVWTDAGTILLLFILFLLVSVKLRNRNKPHKNLPPGPTPLPFIGNVFNLDTSQPHIDLTK

MSDHYGNIFSLRLGSLNTVVVNTYSMVKKVLNDQGNSFMYRPVNDITERISKCQ GLTFNNGYSWKQHRRFTLSTLKFFGVGKRSLEFIIMEEYKFL GLPFNPHYIINNGVSNIICSMVFGRRFEYTDQRFLNMLSLISKALKLQTSVFIQ LYAAFPRLMDLLPGPHKELFSCFHQVRAFIKEEVDKHRADWDPSSPRDFIDCYLTEIEK KKDDLEAGFHDEGLQYAVLDLFVAGTETTSTTLLWAFVYMMKYPEIQ EKVQAEIDKVVGRYRRPSMDDRPCMPYTDAVIHEIQRMGNVVPLSVPRMTNEDTILEGYFIPK 1203555 GTQIIPNLTSVLFDQTKWKTQHSFDPQNFLNAQGKFEKPEAFIPFSL GKRSCPGESLARMELFLFFTSFLQSFSLSAPDETQTSLDFKFGMTLSPKPFKICFTPR

 

>CYP2X6 ctg22265.a 66% to CYP2X1

MLGSSLLVVICILLIFFLIRVKKPKNFPPGPPPVPIFGNLLQLNLANPLKDFEK FAEKYGEIFSLYTGSRPAVILNSFAVIKEALVTKAQDFSGRPQDFMISHATENKGN IVLADYGPVLKGHRRFALMTMRNFGLGKQSMEERILGEISHVVDYLDKNA GKRVDPHIMFHNVASNVISLLLFGCRFDYNSEFLQCYIQLINEISKIINGPWNM IYDTFPLLRILPLPFKKAFDHVKVIKSMNLKLIDEHKSTRVPGEPRDFIDCYLDELDK GKNCVSTFSEDKLLMSIMDLHFAGTDTISNTLLTAFLYLMNHPEVQ VKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANTVPLSVFHCTTRDTELMGYSIPK GTIIIPNLTRVLKEEGQWKFPYEFNPANFLNEQGQFEKPEAFIPFST GLRMCLGEGLARMELFLIFVTLLRRFQFVWPEDAGKPDYTPVFGLTLTPKPYRMHIRRRETVKQ*

 

>CYP2X7 ctg22265.b CYP2X1 Missing C-term CK030199 AI959373 BC053412

MLEVSVLILICIFLVFFLIRIKRPKNFPPGPPPVPIFGNLLQINMVDPLKEFER LAEKYGNIFSLYTGSKPAVFLNNFEVIKEALVTKAQDFSGRPQDLMISHL

TGNKG

VVLADYGPLWKDHRRFALMTLRNFGLGKQSMEERILGEISHIVDFLDKNT GKTVDPQIMFHNIASNVINLVLFGCRFDYNNEFLRGYIQRIAENLRILNGPWNM IYDTFPLLRILPLPFKKAFDNVKIIKSMNRKLIDEHKSTRVPGQPRDFIDCYLDELDK

VKNCVST

FSEDQLIMNIMDMSFAGTDTTSNTLLAAFLYLMNHPDVQ VKCQQEIDDVLEGKDQVTYEDRHNMPYTLAVIHEVQRVANIVPLSVLHCTTRDTELMGYSIPK

GTVIIPNLTVVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFST

GPRVCLGEGLARMELFLIFVTLLRRF

QFVWPEDAGKPDYTPVFGLTMTPKPYRMHIRRRNTVKQ

 

>CYP2X7-de9a ctg22265.c

LGEGLARMELFLVFVTLLRRFQFVWLEDAGKPDYTPVFRHTMTPKPYRMHIRRR

 

>CYP2X7-de9b ctg22265.d CYP2X1 pseudogene? C-term 87% to 2X.b

GPRVCLGEGLARMELFLVFVTLLRRYKFVWPRDAGKPDYTPVFGITMTPKPYRMLIRRRDTVQ

 

>CYP2X8 ctg21275 87% to 2X.a (revised exon 9 chr25:13898064-13898258)

MLGSSVLVLICILLVFLLIRIQRPKNFPPGPSPLPIFGNLLHFNLANPLKDFER FAEKYGNIFSLYTGSRPAVFLNSFAVIKEALVNKAQDFSGRPQDFMISHLTECKGN VVLADYGPLWKDHRRFALMTLRNFGLGKQSMEERILGEISHVVCYLDKNI GKTVDPQVMFHNVASNVISLVLFGRRFDYNSETLQCYIQLITEISKILNGPWNM IYDTLPFLRILPLPFKKGFDHVKVLKGMNLKLIDEHKSTRVPGKPRDFIDCYLDELDK RKNEVSTFSEDQLLMYILDLYFAGTDTTSNTLLTAFLYLMNHPEVQ VKCQQEIDDVLEGKDQVSYEDRDNMPYTLAVIHEVQRVANTVPLSVFHCTTRDTELMGYSIPK GTLIIPNLTIVLKEEGQWKFPHEFNPANFLNEQGQFEKPEAFIPFST

GPRVCLGEGLARMELFLVFVTLLRRYKFVWPRDAGKPDYTPVFGITMTPKPYRMHIRW

RNTVKQ*

 

>CYP2X9 revised BC124413.1 exon 9 chr25:13881559:13888216 (+)

MLGFLILVWICIVLLFLFIQIPRPKNFPPGPRPLPLFGNLLE

LNINNPLKDFERLANRYGNIYSLYFGSKPWVVLNGFEALKEALVTKAVDFAGRPQDLMVN RVTKGGGVILSDYGPSWKEHRRFALMTLRNFGLGKQSMEERILGEVSHIIDKLEKRVG TAFDPQTMFHNAASNIICIVLFGSRYDYDDEFLKLFIHLYTENAKIANGPWAMIYDTF PMFRYLPLPFRKAFANASKARELSTQLVKEHKKTWVPGEPRDFIDCYLDELDKRGNDG SSFSEAQLILYVLDLHFAGTDTTSNTLLTGFLYLMTHPEVQAKCQQEIDDVLEDKDQA SYEDRHSMPYTQAVTHEVQRVANTVPLSVFHCTTKDTELMGYNIPKGTFVIPNLGSAL KEEGQWKFPHEFNPANFLNEQGEFEKPEAFVPFSA

GPRVCLGEGLARMELFLVMVTLLRRFQFVWPNDAGKPDYTPVYGVTLTPQPYRMHIKRRETVRI

 

>CYP2X10 ctg24117.a

MLTALVLLCLGAFLLYLQLRIRRPKNFPPGPAPVPIFGNLLQLNRISPLKDFDK FAQHYGSIYGIYIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGGKGK VIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESA GKSIDPQHLYHQAASNIIASIIFGSRFNYKDAYFQTLITSVEDLTKITIGPWAM LYEIAPVLRIFPLPFQKAFQYFEQITKHVLKVVEEHKTSRVAGEPRDLIDCYLEEME KSDTHRTSFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQ EQCQREIDEVLGARDHVTYEDRNAMHFVQAVIHEGQRVADIAPLSMFHSAKTDTQLRGYSIPK GTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSA GPRVCLGENLARMELFLILVTVLRRFRLVWPKDAGEPDFTYIYGGTQSVKPYRVIVEPR

 

>CYP2X11 ctg24117.b zfishI-a36g12.q1c EXONS 1-7

MLTALVLLCLGAFLLYLQVRIRRPKDFPPGPAPVPFFGNLLQLNRINPIKDLDK FAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQAAEFAGRPNHMMISHITRSKGS VIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESA GKSIDPQHLYHQAASNIIASVIFGSRFNYKDEYFQTLIQTMEKLTKIAIGTWAM LYEIAPVLRIFPLPFWKAFHYFEKITRHSLKVVEEHKKSFVAGEPKDLIDCYLEEMKK RADQRTTFDEAQMVTLLFDLYLAGTETTSNTLRTLTLF EQCQREIDEVLGARDHVTYEDRNDMHFVQAVIHEGQRVADIVPLNVFHTARTDTQLRGYSIPK GTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSA GPRVCLGENLARMELFLILVTVLRKFRLVWPKDAGEPDFTYIYGGTQSLKPYPMIVKLRTPGETHEYAK

 

>CYP2X11-de1 ctg24117.c EXON 1

MLTALVLLCLGAFLLYLQLRIRRPRNFPPGPAPVPIFGNLLQLNHINPIKDLDK

 

>CYP2X12 Danio rerio GenEMBL AY825257 EST partial

MLTALVLLCLGAFLLYLQLRIRRPRNFPPGPAPVPIFGNLLQLN HINPIKDLDKFAQHYGSIYGIYIGSKPAVVLTGQKMIKEALITQGAEFAGRSNKMMVS HVTRSKGVIMADYGESWREHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAG KPIDPQHLYHQAASNIIASIIFRSRFDYQDEYFQTLITTMEKLTKIAIGPWAMLYEIA PVLRIFPLPFHKAFQYFEQITNHVLKVVEEHKTSRVAGEPRDLIDCYLEEMNRRSDKH TTFDESQMVTLLFDLFIAGTETTSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARDHV TYEDRNAMHFVQAVIHEGQRVADIVPLSMFHTARTDTQLRGYSIPK

GTIIIPYLSSSLREEGQWKFPHEFNPQNFLNEKGEFVKNDAFMPFSA

GPRVCLGENLARMELFLILVTVLRKFRLVWPKDAEEPDFTYIYGGTQSLKPYPMIVKLRTPGETHEYAK

 

>CYP2Y3 ESTs CK016257, CK869788, CK706387, CB891035 NA1608

MELSSSLLLVLVLTVLMLIRWRRKENGLSLPPGPLALPLIGNLLTLDKSAPFKSFMK WRKTYGSVMTVHLGPQRMVVLVGYETVKEALVDQAEDFAPRAPIAFMNRIVKGY GLAISNGERWRQLRRFTLTTLRDFGMGRKQMEQWIQEESRYLLKSFEETK SKPVDPTFFFSRTVSNVICSLVFGQRFDYEDKNFLQLLQIISKLLRFLSSPWGQ LYNIFPQVMERFSSRHHAILKDVENIRTFIRNKVKEHEQRLDFSDPSDFIDCFLIRLTQ EKDKLDTEFHKDNLMATVLNLFVAGTETTSTTLRYALMLLIKHPQIQ EQMQREIDRVIGQNRIPTMEDRKSLPFTDAVIHEVQRYMDIVPLSLPHYAMKDITFRGYKIPK DTVIIPMLHSVLRDEGQWETPWTFNPEHFLDSNGNFKKNPAFMPFSA GKRSCVGESLARMELFLFTVSLLQKFTFSSPNGPDGIDLSPELSSFANMPRFYELIASPR*

 

>CYP2Y4 EST AL916779 Zv3 NA1608, zfishC-a2916d05.p1c,

MELSSSLLLVLVLTVLMLIRWRRKENGLSLPPGPLALPLIGNLLTVETSAPFKSFMK WSKSYGPVMTVHIGTQRMVVLVGYETVKEALVDQAEDFASRAPIPFTNRVLRGY GLIISNGERWRQLRRFTLTTLRDFGMGRKRMEQWIQEESRYLLKSFEETK

SKPVDPLFFMSRAVSNVICSLVFGQRFDYEDKNFLQLLQIISNLMRFASSPWG QLYNIFPKVMEILPGRHHTMFGEIDDLKSSIMTII

KEHEENLDPSDPKDFIDCFLIRLNQ

LQQEKHNPDT

EFHKENMFATSLNLFTAGTETTSTTLRYALMLLIKHPHIQ EQMQREIDCVIGQNRIPTMEDRKSLPFTDAVIHEVQRCLDIAPLNVPHYALKDITFRGYKIPK DTVIIPMLHSVLRD

EGHWETPWTFNPEHFLDSNGNFKKNPAFMPFSA GKRVCVGESLARMEIFLFIVSLLQKFSFSSPNGPDSIDPSPELSSFGNMPRLYELIASPR

 

>CYP2AA1_AF497969 74% to 2AA2

MLVGLVKLDLASVGLTLFLGLIFLVLFEIFRINSYKFRFPPGPT PLPFVGNLPHFLKSPMEFIRSMPQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQDAFSG RPAIPLFDWITNGLGIVMVTFNNSWRQQRRFALHTLRNFGLGKKTVEDRVLEESRYLI AEMLKEEGKSMNPQHALQNAISNIICSIVFGDRFEYDNKRFEYLLKTLNENIMLAGSA AGQIFNLVPFIKHFPGPHQKIKQNADELLGFIRDEAKEHKQTLDPDSPRDFIDAYLLE IEKQKSSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQERCHEEIV RVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTRLHGYDIPQGTII LTNLAAIFSNKDHWKHPDAFNPENFLDENGHFSKPESFIPFSLGPRVCLGETLARTEL FLFITALLQRIRFSWPPDAKPIDMDGIMGLVRSPQTFNVVCHSRDNVK

 

>CYP2AA1_ctg10776 98% TO 2AA1 AF497969 probably same gene

MLVGLVKLDLASVGLTLFLGLIFLVLFEIFRIHSYKGRFPPGPTPLPFVGNLPHFLKSPMEFIRS MPQYGEMTTIFFGRKPVIMLNTIQLAKEAYVQDVFSGRPAIPLFDWITNGL GIVMVTFNNSWRQQRRFALHTLRNFGLGKKTVEDRVLEESRHLIAEMLKEE GKSMNPQHALQNAISNIICSIVFGDRFEYDNKRFEYLLKTLNENIMLAGSAAGQ IFNLVPFIKHFPGPHQKIKQNADELLGFIRDEAKEHKQTLDPDSPRDFIDAYLLEIEK QKPSKDSTFHEENLVVSASDLFLAGTDTTETTIRWGLINLIQNPDVQ ERCHEEIVRVLGYDRLPSMDDRDKLPYTLATVYEIQRCANIAPNVMHQTILPTKLHGYNIPQ GTIILTNLAAIFSNKEHWKHPDAFNPENFLDENGHFSKPESFIPFSL GPRVCLGETLARTELFLFITALLQRIRFSWPPDAKPIDMDGIMGLVRSPQTFNVVCHSR

 

>CYP2AA1-de1 ctg10776

MLAALLKLDLASVGLTLFLGLIFLVLFEIFRIYSYKGRFPPGPTPLPFVGSIPHFLNNPMGFIKS LSQYGEMTTVYPGRKPAIILNTLQLMKEALV

 

>CYP2AA2 AI657973 fc19c11.y1, AI958603 fc94a10.y1, AI544967 fb69h12.y1

MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGFNRL MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPAIDWTSNGC GIIMATFNNSWKQQRRFALHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ GTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGV GPRICLGDTLAKTALFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFSIICCSRDTKE*

 

>CYP2AA3v1 BC055136 ctg14330 Zv3 05/2004 zfishC-a1177h12.q1c

MFTALLKLDLASVGLTLFLGLIILVLFEIFRIHSYKRRTPPGPTPLPFVGTIPHFLKNPLGFIR MSQYGDMSTMYLGRKPAIFLNTIQLAKETLVQDTFSGKPYLPVIEWISKGFG GIAMVTFNHSWRQQRRFALHTLKNFGLGKKSVEDRVLEESRYLIAEM LKDEGKPVDPHHPIQNAVSNIICSIVFGDRFEYNNKRFEYLLKMLNETIMLAGSASGR IFNLVPFIKHFPGPHQKIKKNTDDLLIFLGDEVEEHRKTLDPGSPRDFIDAYLLEIEK QKFNKDSTFHEGNLLASAGDLFMAGTDTTETTIRWGLLLLIQNPDVQERCHEEIVRVL GYDRLPSMNDRDRLPYTLATVHEIQRYGNIIPILIHETILPTKLQGYSIPQGTTIVTN IQAIFSSKDHWKHPDTFNPENFLEDGHFIKPESFIMFSLGPRSCLGEMLARTELFLFI TSLLQRIHFSWPPDAKPIDMDGIFGLVHSPQTFNVICRSRDTK

 

>CYP2AA3v2 Danio rerio (zebrafish) ctg14330 (7 aa diffs

MFTALLKLDLASVGLTLFLGLIILVLFEIFRIHSYKRRTPPGPTPLPFVGTIPHFLKNPLGFIRS MSQYGDMSTMYLGRKPAIFLNTIQLAKETLVQDTFSGKPYLPVIEWISKGF GIAMVTFNHSWRQQRRFALHTLKNFGLGKKSVEDRVLEESRYLIAEMLKDE GKPVDPHHPIQNAVSNIICSIVFGDRFEYNNKRFEYLLKMLNETIMLAGSASGR IFNLVPFIKHFPGPHQKIKKNTDDLLIFLGDEVEEHRKTLDPGSPRDFIDAYLLEIEK QKFNKDSTFHEGNLLASAGDLFMAGTDTTETTIRWGLLFLIQNPDVQ ERCHEEIVQVLGYDRLPSMDDRDRLPYTLATVHEIQRYGNIIPILIHETILPTKLQGYSIPQ GTTIVTNIQAIFSSKDHWKHPDSFNPENFLEDRHFIKPESFIMFSL GPRSCLGEILARTELFLFITSLLQRIHFSWPPDAKPIDMDGIFGLVHSPQAFNVICRSRDTK

 

>CYP2AA4 revised exons 4,9 dup exons 3,8 chr23: 39040598-39050579 (+)

MFGALVKLDLSSVGLTLLLGLILLVLFEIFRIHSYKSRFPPGPTPLPFVGNLPHLLRDPMGFNRL MAQYGEMSTMYLGKKPAIVLNTIQVAKEALVQEAFAGRPCLPVIDWTSNGC GIIMATFNNSWKQQRRFALHTLRNFGLGKKSIESRVLEESQYLFAELLKDE GEPVNPHHALQNAVSNIFCSIMFGERFDYDNKRLGYLLKILNENMMLTGSAIGQ

IFNLAPFIKHFPGPHQKIKKNSNELYSFIEDEVEEHRKTLDPVSPRDFIDAYLLEIEK QKSNKDSTFQEENLIGSAIDLFFAGTDSTATSIRWGLLFLIQNPDVQ ERCHEEIVQVLGYDRLPCMDDCDRLPYTHATVHEIQRFAKTVPFGVFHETIWPTKLHGFDIPQ GTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESYIPFSL

GLRACIGESLVRTELFLFATVLLQRIHFSWPPDAKPLDMDGIVGIVRYPQTFSIICCSRDSKK*

 

>CYP2AA4-ie3 ctg14330 dup exon 3

QRRFALHTLRNFGLGKKTVEDRVLEESQYLIAEMLKDEG

 

>CYP2AA4-ie8 ctg14330 dup exon 8

GTMIMTNLAAIFSSKEHWKHPDTFNPENFLDENGHFSKPESY

 

>CYP2AA6 chr23:39008595-39008786 (+) fd54c03.y1 AW019538 = fd54c03.x1

MLAALLKLDLSSVGLSLFLGLIFLVLFEIFRIHSCKGRFPPGPTPLPFVGSIPHFLNNPMGFIKS LSQYGEMTTVYPGRKPAIILNTLQLMKEALVQNGSSFSGRPPVPVFNWVTDGY GIVMATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISEFLKAE GKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENIIQAGSLVGQ VFNLVPIIKHVPGPHQKIYQNGQAFKSFIRESVKEHRQTLDPDSPRDFIDAYLLEMEK QKSTQDSTFHEDNMVMAVGDLFLAGSDTTATTIRWGLIYLTQNPDVQ ERCHEEIVRVLGFDRLPSMDDRDRLPYTLATVHEFQRCANLVPTGVPHETTQATKLRGYDIPQ GTQILINLTEILTNKEHWKHPDTFNPENFLDDKGHFFKPEAFLPFSL GPRACLGETLAKAELFLFVTSLLQRIRFSWPTGEKLPDMNGIFGIVRSPKPFNIICHSRGSKH*

 

>CYP2AA6-ie6 NA16005 Duplicate exon 6 (3 aa diffs)

QKSTQDSTFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQ

 

>CYP2AA7 NA16005 Exons 1-7 83% to 2AA1 96% (6 diffs) to AI964243

MFAALLKLDLASVGLTLFLGLIFLVLFEIFRINSYKGRFPPGPTPLPFVGNLPHSLKNPMEFIRS MPQYGEMTTMYLGRRPAIVLNTIQLAKEAFVQDAFSGRPFLPVMDWVANGL GIIMVTFNHSWRQQRRFALHTLRNFGLGKKSVEDRVLEESRYLIAEILKGE GKPMSPHHPIQNAVSNIICSIVFGDRFDYDNKRFEYLLELLNENFVLTGSAAGQ IFNLAPFIKHFPGPHQKIKQNANELLAFIQGEVKEHKKTLDPDSPRDFIDAYLLEIEK QKSNKDSTFHEGNLAISTADLFLAGTDTTSTTIRWGLLFLTQNPDVQ ERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRCANLVPFGVIHETIQPTKLRGYDIPQ GTVVMTNLAAILSDKEHWKHPDTFNPENFLDENGHFSKPESFIPFSL GPRFCLGETLAKMELFLFITSLLQRIRFSSPPDAKPIDMDGIMGIVRYPQPFSIICCSRDTKE*

 

>CYP2AA8 NA3313 78% to 2AA7 zfishC-a402h10.p1c zfishC-a440h04.p1c

MFSALLKLDLAFAGMTLILSLIFMFLLEIFRIHSFKSRFPPGPSPLPFVGNLPVFLKNPMEFIRS LSQYGEMTTIYLGRKPTIMLNTVQLAKEVLIQDAFAGKPSLPVLDWVSNGL GIVMVTFNHSWRQQRRFALHTLRNFGLGRKSVESRVLEESQYLIAELLKKK GKSVNPHHALQNAFSNVICSIVFGDRFDYDDKRFEHFLEILGKSMILTGSTAGQ IFNFAPIIKHFPGPHQKIKKNADELSGFFQHEVKEHKKTLDPGSPRDYIDAYLLEMEK QKSNKDSTFHDENLIGSTTDLFVAGSDSTATTFRWGLLFLIQNPDVQ ERCHKEIVQVLGYDRLPSMEDRDRLPYTLATVHEIQRCANLAPFGLIHETIQPTKLQGYDLPR GTTIIVNLTAIFSNKENWKHPDTFNPENFLDESGQFSKHESFIPFSL GVRVCLGETLARTELFLFITALLQRIRFSLPPDAKPMDMDGILSVLRYPQNFSFICCSRD

 

>CYP2AA9v1 Danio rerio (zebrafish) GenEMBL AY825258, AL922288

MFTALLKVDLASVGLTLFLGLIFLVVFEIFRIYSYKCRFPPGPT PLPFVGNLPHLLKKPMEFIRSLSQYGEMTTMYLGRKPAIVLNTYQVAKEALVQEAFAG RPHLPIIEWITKGLGIVMVTFNNSWKQQRRFAQHTLRNFGLGKKSLESRVLEESQYLI AEMLKDEGRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSA AGQIFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLE IEKQKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQERCHEEIV QVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETAQPTKLRGYNIPQGTI IMTNYTAIFSNKEHWKHPDTFNPENFLDENGHFSKPKCFIAFGVGPRICLGDTLAKTA LFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFCIICCSRDTKE

 

>CYP2AA9v2 Danio rerio (zebrafish) Chr 23 98% (7 diffs) to 2AA9v1

MFTALLKLDLAFVGLTLFLGLIFLVVFEISRIYSYKCRFPPGPTPLPFVGNLPHLLKKPMEFIRS LSQYGEMTTMYLGRKPAIVLNTYQVAKEALVQEAFAGRPHLPIIEWITKGL GIVMVTFNHSWKQQRRFAQHTLRNFGLGKKSLESRVLEESQYLIAEMLKDE GRPMNPQHAVQNALSNIICSIVFGDRFDYNNKRFEYLLKILNESIILTGSAAGQ IFNFAPIIKHFPGPHQMINENANEVYSFVRHEVEEHRKTLDPGSPRDFIDGYLLEMEK QKSNKDSTFHEDNLITTTVDLFLAGSDSTSSSIRWGLLFLIQNPDVQ ERCHEEIVQVLGYDRLPCMDDRDRLPYTLATVHEIQRCGNIAPFGLFHETVQPTKLRGYNIPQ GTIIMTNYTAIFSNKEHWKHPDTFNPENFLDENGQFSKPKCFIAFGV GPRICLGDTLAKTALFLFITSLLQRIRFSLPPDAKPMDMDGILSIIRYPETFCIICCSRDxx

 

>CYP2AA10 Danio rerio (zebrafish) Chr 23 85% to CYP2AA1

MLAALLKLDLASVGLTLFLGLIFLVLFEIFRIYSYKGRFPPGPTPLPFVGNLPHLLKNPMGFKRS LSEYGGLATVFIGRKPAISINTIQLAKEALVQDVFSGRPALPIFDWISHGL GIIMVTFNHSWRQQRRFALHTLRNFGLGKKTVEDRVLEESQYLIAEMLKDE GKSMNPQHALQNAVSNIICSIVFGDRFEYDNKRFEYLLKILNENIMLTGSAAGQ IYNLVPFIKHFPGPHQKIKQNADDLFNFIRDEAKEHKQTLDPDSPRDFIDAYLLEIEK QKFNKDSTFHEEHLVVSTSDLFLAGTDTTETTIRWGLIYLIQNPDVQ ERCHEEIVQVLGYDRLPSMDDRDKLPYTLATVHEIQRYGNIAPKLLHETIRRTKLHGYDIPQ GTTIIANFTAMFSDKELWKHPDAFNPENFLDENGQFSKPEYFFPFSL GPRACLGETLARTELFLFITSLLQRIRFSWPPNAKPIDMDGIVGIVRSPEPFNIICHSRDxx*

 

>CYP2AA10-de8b9b Danio rerio (zebrafish) Chr 23

GTAIVTNFEAIFSSKDHWKHPDAFNPKNFLEDEHFSKLESFIAFSL xxRSCLGEMLVRTELFLFITSLLQRIHFSWPPDAKPIDMDGIMGLVHSPQTFNVICRSRD

 

>CYP2AA11 Danio rerio (zebrafish) Chr 23 (see below)

MLVGLLKLDLSSVGLSLFLGLFCLALFEICRIRIYKGRYPPGPTPLPFVGTIPHFLKNPMGFIRS LSQYGEMTTVYLGRKPAIILNALQLMKEAFVQNGSSFSGRPPVPVLTWVNQGY GIIMAMDGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLISELLRVE GKPFNPQHAIHNAAANIICSIVFGDRFDYDNKSFTYLLEIIKENLDLAGSFAGQ MVNLVPIIKNLPGPHQKIYQNGEEFKSFIRESVKAHRETLDPDSPRDFIDAYLLEMEK QKSTQDSTFHEDNMVMSVGDLFFAGTDTTATTIRWGLLYLTQNPDVQ ERCHDEIVQVLGFDCFPSMDDRDQLPYTLATVHEIQRCANVAPSGVPHQTTKPIKLRGYDIPQ GTQILINLMGILANKEHWKHPDTFNPENFLDDKGHFFKPEAFLPFSL GPRACLGETLAKTELFLFVTSLLQRIRFSWPTGEKWPDMNRILSVIRSPEPFNIICYSRDS

 

>CYP2AA12 Danio rerio (zebrafish) Chr 23 (see below) 83% to 2AA6

MFASLLKLDLASVGLTLFLGLIFLVVFEIFRIRSYSGRFPPGPTPLPFVGTIPHFLKDSMGFIRS LSQYGEMTTVYLGRKPAMVLNTLQVIKEAIVQNGTSSSGRPSIPILTWITEGY GIVLATFGHSWRQQRRFALHTLRNFGLGKKSVEERVTEESGYLVPEMLKLE GKPFDPQHAIQNAVSNIICSIVFGDRFEYDNKRFEYLLEIIKENINQAGSLIGQ VFNLIPIIKHFPGPHQKIYQNAEELKSFIRESTKSHRETLDPDSPRDFIDAYLLEMEK QKSSQDSSFHEDNMVMSVADLFLAGSDTTATTIRWGLIYLTQNPDVQ ERCHEEIVRVLGYDRLPCMDDRDRLPYTLATVHELQRCGNIVPSSVPHETTQPMKLRGYDIPQ GTQMLINLSDILANKEHWKHPDTFNPENFLDDKGHFYRPEAFLPFSL GPRVCLGETLAKTELFLFITSLLQRIRFSWPTGEKWPNMDGIVSVVRSPEPFKIICHSR

 

>CYP2AA-se1[4] pseudogene exon 4 62% to CYP2AA12 Chr23:38987902-38988065 (+)

KLFDPQHAAQNA

LSNIICSIVLGDRFSQDNIHFTYLFEVESHSGVVT

QAWSLVGQV

 

>CYP2AD2 ctg24224.c AF248042, BC045948, NM_152954, AI497156 fb62g08.y

MILHLIYDSFDFKSWIIFFVVFLIIAEMIKNRTPSNYPPGPWPLPFLGTVFTKMDFKNINK LAKVYGKVFSLRVGSEKMIIVSGYKMVKEALVTQNDSFVLRPPVPLFHKVYKGI GLTMSNGYIWRSHRRFAASHLRTFGEGKKNLELGIQQECVYLCDAFKAEK EPFNPIFILHGAVSNTVACLTFGQRFDYNDEWYQEILRLDNQCVQLAGSPRVQ LYNAFPKLLDYLPGPHQKVFSNYKKITQSLKDEIIKHREDWDPANPRDFIDNYLTEMEK KKSDPQAGFNIESLIISCLDIVEAGTETGATTLRWGLLFMIKFPEIQ EKVQAEIDRVIGQSRQPCLDDRVNMPYTEAVLHEIQRFGDVVPLGFPKQAAVDTKIGNYFIPK GTSITTNLSSVLHDPNEWETPDTFNPGHFLDKNGQFRKRDAFLPFSA GKRACVGELLARNVLFLFFTSLLQQFTLSKCPGEEPSLEGEIWFTYAPAPFRISVSVR

 

>CYP2AD3 ctg24224.d Zv3 05/2004

MILQFIYENFDFKSWILLGFGLLLLVDLIKYWNPSSFPPGPRPLPFLGNVFTEIQDFRNINK LAQVYGTIFSLRLGSEKLIIVSGYKMAKEALVTQNDSFIDRPNVPLFHKVFKGL GTILSNGYLWRMHRKFAVSHLRNFGVGNESLEVKIQQECIFLCDAFKAEK GPVDPMVTLNSAISNIISSLIFGQRFDYHDEYYQRILRLDTECIQLAGSPRAQ LYNACPWLFEYLPGPHQTIFSNYKKIKDFLRGEIIKHREDWDPANPRDFIDNYLTEMER KKSDPEAGFNIEGLVVTCLDLIEAGTETATTTLRWGLLFMIKFPEIQ EKVQAEIDRVIGQSRQPCLNDRVNMPYTEAVIHEIQRFGDVVPLGFPKRAVKDTQLGKYFIPK GTAITVNLSSVLHDPNEWETPDTFNPGHFLDEIGQFRKRDAFMPFSA GKRACLGENLARQELFLYFTSLLQQFKISKCPGEEPSLEGEIWFTYAPAPFHICVSSR

 

>CYP2AD6 ctg24224.b 54% to 2AD3 zfishC-a250a11.q1c (100%)

MILYSLYDCLDFKGWLFLTCFLLLLIDLIRNKNPANFPPGPWPLPILGNVFTDVNYKTVDQ LIEKYGNIFSVRIGSDKIVYVSGFKMVKDVLITQGENFTDRPVSPLFDTLYKGR GLSFNNGYSWRKHQQFSMSHLKNFGEGRKTLEENNQRECYFLCGAFKEEQ GRPFDPLVKINNAVANVIGFLVFGHRYEYSDVNFQKRLQMSAESVFLTGSVWNQ 1LYDAFPGIMKWVPGPHQTIISNYQKLANFLEEKIEQHKPDWDISNPRDYIDAYLTEAEK KKNDTEAGFTVGSLVWSMVDLFEGGTETTTNTLRWALLFLIKYPDIQ EKVQAEIDEVIGSRLPSMSDKANMHYLNAFIHEVLRRANLVPLNMARVAKKDTTLGGYFITK GTVMITNLTSVLYDKQEWETPDAFNPKHFLDSEGHFCRRNAFFAFSA GKRQCPGEYLAHLELFIFLTILLQTFSFSPPDGEEPSLDSQVGFTQAPLPYKICAHPR

 

>CYP2AE1 chr23:39385089-39398315 (+) exon 9 corrected

MSSVFSQLIGQWLDVQGFLIFLCVLLLVKHFRDVYSKNMPPGPFPLPFVGNLTNIGFSDP

LGSFQR

IAEKYGDVCTLYLGTKPCILMTGYDTLKEAFVEQADIFTDRPYFPIVDKLGN AGLIMSSGHMWRQQRRFALATLKYFGVGKKTLENAILQECRFLCDSLQAER GLPFDPQHLVTNAVSNIICGLVFGHRFEYDDHQFHLMQTYINNILQLPISNWGR LYNEFPTLMSLLPGKHQTAFASMSKLQPFLKEEITKHQQDREPSSPRDYIDCYLEEIEK QCKDSDAEFTEENLMFCVVDLFGAGTETTSNTLRWALAFMVKYPDVQ EKVQSEIDQVIGQTRQPLMDDRTNLPYTYAVIHEIQRFANIVTFTPPRVANKDTTVGGQLIPK GVIVLPMLKPILLDKKEYSTPYDFNPDHFLDQNGKFLKKENFIPFSI

GKRMCPGEQLARMELFLFFISLMQHFTFLPVEGQKLSLKGTTSVSSAPQPFQIRAVPR*

 

>CYP2AE1-de9 extra exon 9 chr23: 39410027 to 39410200

GKRMCPGEQLARMELFLFFISLMQHFTFLPVEGQKLSLKGTTSVSSAPQPFQIRAVPR*

 

>CYP2AE2 73% to CYP2AE1 Z35723-a2390a11.q1c chr23:39438356-39465839 (+)

MASVFSQLIGQWLDVQGFLIFLSVLLLVKHFRDVFTNNMPPGPFPLPFVGNVLSIGFGDPM

VAEKYGDVCTFYIGTKPCILMTGYEVFKEAFVEQADIFTDRPFFPVNDRICKGKG

VGLIFSGGHMCRQQRRFALATLKYFGVGKKTLENSILQECRSVCESVQSER

GLPFNPHYILTYAVGNVICSLVFGYKFDYGNDDFNKLLDYSDDTFKLPINIWGR

LYNAFPSVMPLLPGKHQTAFANLTKLKLFFQEEINKHKENRNPYSPRDYIDCYLEEIEK

QCKDKEAEFTEENLIHCVLDLFGAGTESTAKTLVWALLYMAKYPDVQ

EKVHTEIDQVIGQSRQPLMEDRAHLPYTYAVMHEVQRFANVLAFIPPRVASKDTTVAGFLIPK

GVMVLPMLKPILEDKNEYCTPNEFNPAHFLDENGKFVKRENFIPFSI

GKRMCPGEQLAGMELFLFFISLMQHFTFLPPEGETLSLKRTVAIASAPAPFRIKAVPRQCDNTAS*

 

>CYP3A65 ESTs CF266016 CF999879 CF996069 CD014436

MFFSAETWTLLAFLVALLVI

YGSWPHRYFKKLGIPGPKTIPFFGTMLRYKD

GFHVFDMDCFEKYGRIWG

IYDGRQPVLCIMDQTIIKTVLIKECYSLFTNRR NFRLNGALYDAVSIAEDDDWRRIRSVLSPSFTSGRLKE

MFGIMKKHSHILVDSMGKTAKRGESADIKE FFGAYSMDVVTSTAFSVDIDSLNNPKDPFVTNIKKMLKFDLLNPLFLLI AFFPFMAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTK KRVDFLQLMVDSQTGVKHKSDGETHEK GLSDHEILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETFPNQAPVD YETLMSMDYLDAALSESLRLYPVAARLERVCKKTVEING LLIPKDLVVMVPTYVLHRDPDYWSEPESFKPER YETMMSMDYLDAALSESLRLYPVAARLERVCKKTVEING LLIPKDLVVMVPTYALHRDPDYWSEPESFKPER FTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQRFDVSVCDETQ VPLELGFNGLLSPKDPIKLKLQPRKLSQSPDVCNNNQKS*

 

>CYP3C1 NM_212673 AW076890, BF717373 fd45a03.y1 38092657-38099400 (-)

MFDLSSLSVTWTLVVLVITLLLI YGVWPHGFFKKLGIPGPRPLPFVGTALSYSK GICNFDIECSKKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFT NRRNMNPDLVGPFADGITLVKDERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKN MEKKDPNLPLKIKDVVAPYSLDVVASSSFSVDFDSINNPDDPFVTSIKSFFNINPLSP LFLLLAFCPSAANLLAKMGISVFSRSTTDFYYKALRKIKDEHNESNGRVDFLKLMIQN QIPDDQVKDTASEQPVKGLTDHEILSQSFIFILGGYETTSTTLSYLLYNLATNPDCLE KLVEEIDKNFPLDIPITYDALMRMDYLEMAIHESMRVFPAGPRLERVCKKTVEINGIT IPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPESKTEINQCAFMPFGLGPRNCIGM RFALMMMKLLVVKLLQKYTVETCKETQIPVQLNFFFQPKVPITLKLIPRSHKEKQ

 

>CYP3C2 XM_681689.1 50% to 3B2 77% to 3C1 chr3:38082058-38088716 (-)

MIDLSSLSVTWILVVLVLTLLYM

YGVWPHGFFKKLGIPGPRPWPFFGTFLSYTK

GFFNFDMECAKKYGKVWG

IYDGRLPILMVTDLEMIKTIMVKECYSTFTNRR EINVDLAGPLADGITAVKDERWKRIRGTLSPYFTSGRLKE

IFPIAMTHADRFIKNMQ

KGDHEQPVKIKEV

MASYSLDVVTSSAFSVDIDSINNPDDPFVTNIKNFLKFN

LFGLFVLLLT

VFPSIANLLGKMGLSMFSKPTVDFFYKALRKIKEEHKDSN GRVDFFRLMIQNEIPDDQVKDTTSEQPEK GLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKIDKNFPLDT PISYDALMKIDYLEMSINESMRLLPTAPRLERVCKKTVEMNGITIPKDTMITIPTYVLNQ DPQLWDSPHEFRPER FSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKETQ IPLELNPVFQPKVPITLKLTPRKRNN*

 

>CYP3C3 BC085438.1 CK866601.1 90% to CYP3C.b chr3:38071698-38076958 (-)

MIDLSSLSVTWTLVFLVITLLYM

YGVWPHGFFKK LGIPGPRPWP

FFGTFLSYTK

GFFNFDMECAKKYGKVWG

IYDGRLPILMVTDLEMIKTIMVKECYSTFTNRR EVNVDLAGPLADGISAVKDERWKRIRGTLSPYFTSGRLKE

IFPIAMTHADRFIKNMQKRDHEQPVKIKEV VAPYSLDVVTSSSFSVDIDSINNPDDPFVTNIKNFLKFS

LFSPLILFLT

LFPSIANLLGKMGISVFSRSIMNFFYTALRKIKDEHKDSN

GRVDFLRLMIQNQIPDDQAKDTTSEQPVK

GLTDHEILSQSFIFI LGGYETTSTTLSFLL

HNLATNPDCLEKLVEEIDKNFPLDT PISYDALMKMDYLEMSINESMRLLPTAPRLERVCKKTVELNGITIPKDTLVAIPTYVLNR DPQLWDSPQEFRPER

FSPENK SEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKETQ IPLELTPVFQPKVPITLKLTPRKRNN*

 

>CYP3C4 BC124295.1 79% to CYP3C.c chr3:38059985-38068827 (-)

MIDLSFLSVTWTLVVLVITLLFIYGVWPHRFFIKLGIPGPRPWP FVGTLLSYAKGLCNFDMECAKKYGKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFI NRRKRTTGLAGPFSDGIIMVKDERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKN MQKKDPEQPVKIKEVVAPYSLDVITSSSFSVDIDSINNPEDPFVINVKKFIQFNMFNP LLLLILLFPSLAIPLKKMGVTLFSKSAMDFFYSVLKKIKDDHNKESEGRVDFLKLMLQ NQIPDDQIQDSDTSEQPAKGLTDHEILSQSLVFILGGYETTSTTLTFLLYNLATNPDC LEKLVEEIDKNFPLDTPITYDALMRMDYLEMAINESMRLLPTAPRLERSAKKTVVING LTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFSPENKSEFLQYAFIPFGLGPRNCI GMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMNVTFQPKVPITLKLIPRSCNKKQ

 

>CYP4F43 BG799227 (exons 1-4) NA16252 (exon 2) NA2909 (exons 3-12)

MMLFGLSVTGILALSGAALLCALVTRIIINRRALRCFNQPPLRNWIMGHMGL MGHNEEGLQRVDDLVCKYGHSCSWFLGPFYNMVRLFHPDYIRSLLTAS

ASITLKDRIFYGFMKPWL

GNCLLLQSGQEWSRHRRLLTPAFHFDILKKYVHIFNQSTNIMH DEWRRLLASGEHSVDMFEQISSLTLDSLLKCTFSCDTHSQE

KPRQYISAILDLSRLLVQRQHYLPYHWD WLYWRSAQGRRFQQACAVVHQFTADIVQERRTQLDQQSDPESHPENTGRYRKRKNTDLIDLLLLAK

DDKGEALTNEEIKAHADMFMFA

GHDTTASALSWIFYNLAMNQDYQERCRAEVRDLLADRDTHTIGW EDLSQLTFTTMCIKESLRLHSPVLALTRYYSQNMKTPGDCVIPH

GCLCLISIYGVHRNPQVWPDPL

VFDPTRFDPHNSDSRSPHAFIPFSAGPR NCIGQNFAMAEMKVVVALTLARFKILPGPKPVRRLYQLVLRAEGGMILHFQELNEE*

 

>CYP4T8 BC056734, NM_199216, CF943677 AI959112 fd24f08.y1 AI558878

MLLYGISPFVLSVNHVFALIFLACLLTVVKLLIVRRKGVKTMER FPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQFAFPLWFGPSLAVLNIHHPSYAKT ILTTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKLISDS TKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFD LCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQG IVKNRRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLAC NPEHQEKCRQEIQQALDGKDTLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPL TFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENAANRSPHAFVPFSAG

PRFVTRSV

 

>CYP4V7 ctg12974 69% to CYP4V 70% to 4V5 fugu, 70% to 4V6 396649

MGILFGLYILGILFTAVLLLLLASTAYNPLKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAG DFFNQIIEGTNENRHLPLAKVWVGPVPFLILYHAENIE

VVLSNSRHLDKSYSYRFLHPWLGTGLLT STGEKWRNRRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCALDIIC

ETAMGKKIYAQSNADSEYVQSVYK MSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTAN VIRERAEFMSSEPDSDSDQGGRKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFE GHDTTAASMNWALHLIGSHPEVQKAVQAELQEVF GSSERHVGVEDLKKLRYLECVIKESLRIFPSVPLFARSICEACHI DGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPYAYIPFSAGPRNCI GQRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQRRSK*

 

>CYP4V7-ie6 ctg12974 duplicate exon 6

MSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTA

 

>CYP4V8 ctg26375 Length = 1844770 zfishC-a2539b10.q1c 71% to 4V5

MVAFVGVYTYGFVAASVCVICFAYITYQLLKSYLHKWKELKPIPGIGNTFPFIGNALQFKSNGG DFFLQLVGYTTEFQNSPLLKIWIGPIPFLILFHAETVE

TVLNNPVHIDKAYAYQFLHPWLGTGLLT STGDKWRRRRKMLTPTFHFSILTEFLEVMNEQAEVLIEKLEKQAGKGPFNCFSHITLCALDIIC

ETAMGKRIYAQSNYDSEYVRTVYR MSDIITRRQRMPWYWPDFVYNYVGEGREHNRSLKILHSFTES VINERAEYLSYVESDSESDQGMRKRRAFLDMLLKTKDEDGKMLTHKDIQEEVDTFMFE

GHDTTAAAMNWAIHLLGSHPEVQRKAQQELFEVF GESERPVNTEDLKKLRYLECVIKESLRLFPSVPFFARTICDDTQI DGFKVPKGTNIVVITYALHRDPRFFPDPEEFRPERFLPENCVGRHPYAYIPFSAGLRNCI GQRFAIMEEKVILAYILRYFNIVACQKREELRPLGELVLRPEQGIWITLERRKLTMS*

 

>CYP5A1 AY398422 BG728082 BF718045 AW595283

MQLLVDGLKWFGVEASGLSLTVCLFLLFLSLLYWYSISPFSNLE RCGIKHPKPLPFIGNLMMFRNGFFKSQADLINKYGRICGYYIGRRSTVIIADPDMLRQ VMVKEFNKFPNRMTARGITKPMSDSLIMLKGEQWKRVRSILTPTFSAAKMKEMVPLIN TATETLLRNLKSHAESENSFNIHKCFGCFTMDVIASVAFGTQVDSQNNPDDPFVHQAS KFFAFSFFRPIMIFFMAFPFLLRPLAGLLPNKSRDEMNSFFTQCIQKMIKQRDDLSPE QRRKDFLQLMLDVRTNNKFLSVEHFDVVNDADEEAYDGHENSPANESTKRSQQKRMMT EDEIVGQSFIFLVAGYETSSNTLAFTCYLLAVHPECQKKLQEEVDEFFSRHEMVDYAN VQELKYLDMVICESLRLYPPAFRVARDVEEDTVLNGQFLPKGASLEIPTGFLHYDPEH WTEPTKFIPERFTPEAKARRHPFVYLPFGAGPRSCVGMRLAQLEIKVALVHIFRRFNV LACEDTEIPLELKSHTTLGPKNGVMVKITERENLEDAS

 

>CYP7A1 BC054571 BF718169 fd57d07.y1 BF717505 fd45f11.y1

MILTISFIWAIVVGLCCCLWLITGIRRRHPAEPPLENGWIPFLG CALQFGANPLEFLRSRQKKHGHIFTCKIAGQYVHFLCDPFSYHAVIRQGRHLDWKKFH FDASAKAFGHESMDPSQGYTTENLHQTFLKTLQGDALSSLIETMMENLQGTMLQSGML KATTSEWQSDGIYAFCYKVMFEAGYLTLFGKELDGDQSIARQQAQKALVLNALDNFKE FDKIFPALIAGLPIHVFKSAYSAREKLAKTMLHENLSRRANVSDLISLRMLLNDTLST FNELSKARTHVAILWASQANTLPATFWTLFHMIRCPAAMKAASEEVRQTFESSNQKVD PTNSRLVLTREQLDNMPVLDSIIKEAMRLSSASLNVRMAKSDFLLQLDNKESYHIRKD DVIAMYPPMIHFDPEIYDDPLEFKYDRYIDEKGQEKTAFYRNGRKLRYYYMPFGSGVT KCPGRFFAVHEIKQFLSLLLSYFEMELLDSDVKEPPLDQSRAGLGVLQPTYDVDFRYR LKSL

 

>CYP7C1 51% TO 71C1 FUGU ctg22254 BI473289 fp42a01.y3

MLEYLLTILLGFISVLLLYSFCGRRR

KDGEPPLIKGWIPFLGKALEFRKNSQEFLTRLQKEHGDDFTVL CVSLGRYITFIMNPLQYPSVIKHGKQLDFHTFSDSAASRTFDYPPIRSGHFPGLSDQIQR SYTLLQGPALDPLTFSMMGNLQKVLRQLFLSGDEADDHWQQAELYKFCKSAMFQSTFKT LYGHSPHLDLDQLREDFEKFDDMFPLLMARIPIGLLGKTKEIREKLIHFFYPQRMM EWTAPCEFVQTRTALFQDYDTLQDRDKA AHHFAMLWASVGNTIPAALWCLYHLISCLEALAAVREEITNVLGEKNMQLIFKEDIAITR

QQLEQMVYL

ESSVNESLRLYSVSMNIRVVQEDFCLRLDGQRSINMRKDDIIALYPQSTHLDPEIYKEPK FQFDRFVKDGKEKTDFYKSGQKVRYYRMPFGSGATQCPGRFFAMNELKQFVCVTLLMCEM QLLDGQQEASMDNSRAGLGILPPANPIPFKYKTR

 

>CYP7D1 BG883457 fp29f09.x1 381-502 54% to 7A Z35725-a6349d05.p1c

MLIITVFVCRKPGEPPLVTGWLPFIGVTKDYVSNPLGFLTETQKKHGNVFTCLIAGKYFTFV TDPFSFSSVVRQGKNLDFQKFAINFSQR VFGHADFNSPQLSGNYREIHSIFRQTLQGPSLQHLTQSMLCNLQTVLERCLPHEH DWLEEGVQSFTNRIMFEAGFLTLFGKEDIRFLQDHGMSGNRISMPKATQDFLVFDHAFPL LAAGVPIGLCTKAWRAREALAEELLHDELHRRKCISDLIQRRMDIFDRMLLDETGKART DVCMLWASQANTLPAAFWSLYYTLK

SVDAFTAARTEVNRVLLGQSLNNKDQTVYLSKDQLDSMTVL ESIIEEALRLSSASMMIRVASDDFTLTLESDQTAAIRKGDYIALYPQLLHLDPEIYPNPT EFKYNRFLDENDQPKTNFFKSGRRLRNFLMPFGSG ASECPGRFFAVYEIKLFLALTLWHYDLQLRDPDVPVVQDSARAGLGIMPPSQDVLLRFR KKQRTPGNEHKDTK*

 

>CYP8A1 BX546446.15 02-SEP-2004 clone DKEY-7K24 in linkage group 6

MMWTALLLVGLSILVIVLYGRRTR

RRNEPPLDKGMIPWLGHALEFGKDAAKFLTRMKEKHGDIFT VRAAGLYITVLLDSNCYDAVLSDVASLDQTSYAQVLMKRIFNMILPSHNPESEKKRAEM

HFQGASLTQLSNSMQNNLRLLMTPSEMGLKTSEWKKDGLFNLCYSLLFK TGYLTVFGAENNDSAALTQIYEEFRRFDKLLPKLARTTINK EEKQIASAAREKLWKWLTPSGLDRKPREQSWLGSYVKQLQDEGIDAEMQRRAMLLQLWVTQ GNAGPAAFWVMGYLLTHPEALRAVREEIQGGKHLRLEERQKNTPVF DSVLWETLRLTAAALITRDVTQDKKIRLSNGQEYHLRRGDRLCVFPFISPQMDPQIHQQPE MFQFDRFLNADRTEKKDFFKNGARVKYPSVPWGTEDNLCPGRHFAVHAIKE LVFTILTRFDVELCDKNATVPLVDPSRYGFGILQPAGDLEIRYRIRF*

 

>CYP8B1 68% to 8B1 fugu 91% to CYP8B.b AI558624 chr2:2632344-2633870 (-)

MALVQILLALLISVIGALYLLGSFRRRRTGEPPLEKGPIPWLGHVLEFRKDTAKFLNRMKA KHGDIFTVQLGGFYFTFITDPLSFGAVVKEARAKLDFTKFAEQLVQRVFGYHSIQSEHKV LQASSTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYSYNIVFRAGY LSLFGNESPKGTGKESVEKAKEIDRQESNDLFWEFRKYDQLFPNLAYGVLGPSEKMEAER LKRLFWSTLSVQKMRARDNISGWVSDQQQVRAEHGMQEFMQDRYMFLLLWASQGNTGPSA FWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTPILDSAVEETL RLTAAPILTRAVMQDMTIIMANGQEYKIREGDRVAVFPYVVHVDPEVHPDPLTFKYDRF LNADGSRKTDFYKGGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYFDFELTNP NEQIPGIDIRRWGFGSMQPDRDIQFRYRPRI*

 

>CYP8B2 ctg10820 66% to 8B1 fugu 93% to CYP8B.c chr2:2598912-2600450 (-)

WLGCVLEFRKDTVKFLQRMKAKHGDIFTVQLGGFYFTFITDPQSFGAVVKESRAKLDFTN FADQLVERVFGYGAVEIKHKFFKNLQTTSTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSG NGKVWQESGLFAYSYNIVFRAGYLSLFGNESPKGTGKESVEKAKEIDLQHSNDLFWEFR KYDQLFPNLAYGVLGPRGKMEAERLKRLFWNMLSVQKMKARDNVSGWVSDQQQVRAEHGM QEFMQDRFMFLLLWASQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGG PLIDLSRDMLLKTPILDSAVEETLRLTTAPLLTRGVMEDMTIIMANGQEYKIREGDRVSV FPYLVHIDPEVHPDPLTFKYDRFLNADGSRKTDFYKDGKKLKYYSMPWGAGTTMCPGRF FATNELKQFVFLMLSYFDLELKNPNEEIPSIETRRWGFGSMHPDRDIQFRYRPRI*

 

>CYP8B3 ctg10820 66% to 8B1 fugu (no introns) chr2:2583437-2584966 (-)

MESLVQILLALLLSVIGALYLLGGFRRRRTGEPPLEKGLIPWLGCVLEFRKDTVKFLQKM KAKHGDIFTVQLGGFYFTFITDPLSFGAVVKESRAKLDFTKFSDQLVERVFGYHPMENEH KFLQTASTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYCYNIVFRA GYLSLFGNESPKGTGKESVEKAKEIDLQHSNDLFCEFRKYDQLFPNLAYGVLGPRGKMEA ERLKRLFWSTLSVQKMRVKDNISGWISDQQQVRAELDMQEFMQDRFMFLLLWASQGNTGP SAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTPILDSAVEE TLRLTTVPLLTRGVVQDMTIIMANGQEYKIREGDRVSVFPYLVHIDPEVHPDPLTFKYD RFLNADGSRKTDFYKDGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYFDFELT NPNEQIPDIDIRRWGFGSMHPDRDIQFRYRPRI*

 

>CYP11A1 BC054701

MARWNVTFARLDQSLSSLKNLLQVKVTRSGRAPQNSTVQPFNKI PGRWRNSLLSVLAFTKMGGLRNVHRIMVHNFKTFGPIYREKVGIYDSVYIIKPEDGAI LFKAEGHHPNRINVDAWTAYRDYRNQKYGVLLKEGKAWKTDRMILNKELLLPKLQGTF VPLLEEVGQDFVARVNKQIERSGQKQWTTDLTHDLFKFSLESVSAVLYGERLGLLLDN IDPEFQHFIDCVSVMFKTTSPMLYLPPGLLRSIGSNIWKNHVEAWDGIFNQADRYIQN IFKQWKENPEGNGKYPGVLAILLMQDKLSIEDIKASVTELMAGGVDSVTFTLLWTLYE LARQPDLQDELRAEISAARIAFKGDMVQMVKMIPLLKAALKETLRLHPVAMSLPRFIT EDTVIQNYHIPAGTLVQLGVYAMGRDHQFFPKPEQYCPSRWISSKRQYFKSLGFGFGP RQCLGRRIAETEMQIFLIHMLENFRIEKQKQIEVRSKFELLLMPEKPIMLTIKPLNASR

 

>CYP11A2 zKp91C1 80% to BC054701 CYP11A1 zebrafish

MARWSLSARLDQSVSSLKHLLQVIVTRSGRAPAIGLQDSTVRPFNEIPGQWRNSLKSVF AFAKMGGLRNIHRIMVHNFNTFGPIYR EKVGFYESVNIIKPEDAAILFKAEGHYPKRLTIDAWTAYRDYRNRKYGVLLK DGEDWKSNRIILNKEVISPKVQGNFVPLLDEVGQDFVARVNKKIERSGQNQWTTDLSHELFKFALE AVSAVLYGERLGLLLDYIDPDSQRFIDCITLMFKTTSPMLYLPPGLLRPIRSK IWRNHVEAWDGIFNQ ADRCIQNIYRQLRKNPEGNGKYTGVLASLLMLDKLSIEDIKASVTELMAGGVDT TAITLLWTLYELARNPDLQEEIRAEISAARIASKGDMVQMLKMIPLVKGTLKETLR LHPVAVSLQRYITEDIVIQKYHIPAG TLVQLGLYAMGRDHQVFPNPEQYLPSRWVNSQNHYFKSLSFGFGPRQCLGRRIAETEMQLFLIH MLENFRIEKQRQMEVKSMFELILLPEKPIMLTIKPLNSSR

 

>CYP11B1 70% to Fugu 11B1 BI880530 AL916948 Z35724-a4708b08.q1c

MFSSCAGSVCARPHLCVRASVCVRPLHQSSRSA GAARLFQEIPDTGSNGWMNLLRFWRDGRFSRMHKHMEESFRRLGPIYR EHLGSQSSVNIMLPMDTGELFRSEGLHPRRMTLQPWATHRETRRHSKGVFLK NGTEWRADRLLLNREVMVSSSVHRFLPLLDEVAQDF CRSLRRRVQADGFEKAGQHTLTLDPSPDLFRFALE ASCHVLYGERIGLFSSCPSDESERFISAVERMLATTP PLLYLPPRLLLRLRASLWTTHATAWDDIFSH AEQRIQRSYQRLQARASAAPDCSFPGVLGKLMEAGQLSLELIQIHITELMAGGVDT TAVPLQFALFELARNPDVQECVRAQVLSSWRQASGDPLNALQGAPLLKGTLKETLR LYPVGITVQRYPVRDIVLQNYHVPAG

TLVQVCLYPLGRSAEVFSRPECFDPSRWSADADAGSAGGFRSLAFGFGSRQCVGRRI

AENEMQLLLMH

ILRTFKLTVSSTEELSTKYTLILQPECPPRITFSTLTHQH*

 

>CYP17A1 NM_212806 NM_201173 AI883222 fd17f05.y1

MAEALILPWLLCLSLFSAVTLAALYLKQKMNGFVPAGNRSPPSL PSLPIIGSLMSLVSDSPPHIFFQDLQKKYGDLYSLMMGSHKLLIVNNHHHAKEILIKK GKIFAGRPRTVTTDLLTRDGKDIAFADYSSTWKFHRKMVHGALCMFGEGSVSIEKIIC REASSMCEVLTESQNSAVDLGPELTRAVTNVVCALCFNSSYKRGDAELESMLQYSRGI VDTVAKDSLVDIFPW LQIFPNKDLRILRQCISIRDKLLQKKYEEHKVTYSDNVQRDLL DALLRAKRSSENNNSSTRDVGLTEDHVLMTVGDIFGAGVETTTTVLKWSIAYLVHNPQ VQRKIQEELDSKIGKERHPQLSDRGNLPYLEATIREVLRIRPVSPLLIPHVALQDSS V GEYTVQKGTRVVINLWSLHHDEKEWKNPELFDPGRFLNEEGDGLCCPSGSYLPFGAGV RVCLGEALAKMELFLFLAWILQRFTLEMPTGQPLPDLQGKFGVVLQPKKFKVVAKVRA

DWEKSPLMQHC

 

>CYP17A2 NA10451 66% to CYP17A2 FUGU 53% to zebrafish 17A1

YGPLFGLYAGPHLTLVVSEIGLVREVLLQRGREFAGRPKM VTTDLLTQGGKDIAFADYSPLWKNHRRLVHSSFTKFGEGSNKLQTI VQEAADSLCEELQACRGQSSDLSVVLMRAVTNVICRLVFSSSYQPSDPELQTVIQYNDGIVQTI

ARGGLVDIFPWLK

IFPNKDLKRLKECVSIRDQLLYKKLLEHK KSLTPGEPRDLLDALLIGQQRGSGGADDITEDHVLMTAAEAFGAGVETTSTTLLWTIAFLLHHPQ

LQERVQAELDECVGVDRPPCLSDRPHLPLLDAVLCEVMRIRPVSPILIPHVAMQDTR LGGHSVPKGTRVLVNMWAIHHDPKHWTQPEQFNPG RFLEPSGKKKTQSSFLPFGAGPRVCVGESLARIELFLFVSRLLQRFSFSCPSEASLPDLQ GRFGVVLQPERYTVTVTPRH*

 

>CYP19A1 = 19a AF183906 AF004521 AF226620 AF183907 (alt splice) ovarian

MAGDLLQPCGMKPVRLGEAVVDLLIQRAHNGTERAQDNACGATA TILLLLLCLLLAIRHHRPHKSHIPGPSFFFGLGPIVSYCRFIWSGIGTASNYYNSKYG DIVRVWINGEETLILNRSSAVYHVLRKSLYTSRFGSKLGLQCIGMHEQGIIFNSNVAL WKKVRAFYAKALTGPGLQRTMEICTTSTNSHLDDLSQLTDAQGQLDILNLLRCIVVDV SNRLFLGVPLNEHDLLQKIHKYFDTWQTVLIKPDVYFRLDWLHKKHKRDAQELQDAIT ALIEQKKVQLAHAEKLDHLDFTAELIFAQSHGELSAENVRQCVLEMVIAAPDTLSISL FFMLLLLKQNPDVELKILQEMDSVLAGQSLQHSHLSKLQILESFINESLRFHPVVDFT MRRALDDDVIEGYNVKKGTNIILNVGRMHRSEFFSKPNQFSLDNFQKNVPSRFFQPFG SGPRSCVGKHIAMVMMKSILVALLSRFSVCPMKACTVENIPQTNNLSQQPVEEPSSLS

VQLILRNTL

 

>CYP19A2 = 19b AF183908 AF226619 AF120031 brain

MMEHVVKDAVNIGAVVQGTLLLLTGTLMLILLHRIFGVKNWRNQ SALPGPGWWLGLGPVLSYSRFLWMGIGTACNYYNEKYGSIARVWINGEETVILSKSSA VYHVLKSNNYTGRFASAKGLQCIGMFKQGIIFNSNIAKWKKVRTYFTRALTGPGLQKS VEVCVSATNRQLDVLQEFTDASGHVDVLNLLRCIVVDVSNRLFLRIPLNEKELLIKIH RYFSTWQTVLIQPDIFFKLDFVYRKYHLAAKELQDEMGKLVEQKRQAINNTEKLDEMD FATELIFAQNHDELSVDDVRQCVLEMVIAAPDTLSISLFFMLLLLKQNSAVEEQIVQE IQSQIGSRDVESADLQKLNVLERFIKESLRYHPVVDFIMRQSLEDDYIDGYRVAKGTN LILNIGRMHKTEFFKKPNEFSLENFENTVPSRYFQPFGCGPRACVGKHIAMVMTKAIL VTMLSRFTVCPRHGCTISTIRQTNNLSMQPVEEDPDCLAMRFIPRAQNSNGETADNRT SKE

 

>CYP20A1 Danio rerio (zebrafish) ctg10765 74% to fugu

MLDFAIFAVTFVIILIGAVLYLYP

SSRRASGVPGLNPTEEK

DGNLQDIVNKGSLPEFLVGLH

DEFGSVASFWFGARPVVSLGAVNQLRQHINPNWT TDSFETMLKSLLGYQSGSGVGLTESMMRKKVYEGAINKTLENNFPLLLQ QVEELVDKWASYPKSQHTPLCAHFL

GLAMKAVTQLAMGSRFRDDAEVIRFRKNHEA

IWSEIGKGYLDGSLEKSSSRKAHYES

ALAEMESVLKSVAKQRPGQGSSQSFVNYLLQANLTERQ

VMEDGMVFTLAGCVITAN

LCIWAVHFLSVSEAVQDRLYHELVEVLGDELVSLEKIPQLR YCQQVLNETVRTAKLTPVAARLQEVEGKVDQHVIPKE

TLVIYALGVVLQDADTWSLPYR

FNPDRFAEESVMKSFSLLGFSGSQACPELR FAYTVATVLLSTLVRRLRMHRVDGQVVEARYELVTTPKDDTWITVSKRN*

 

>CYP21A1 AL953915.4 Zebrafish exon 7 boundaries not certain,

MCFSVVSVVLLLFILWMLVVKFWRQSHRRTDG IVILICVSFYCPIAVFPKLLHSLYKLFFSTVSPTISGPRSL PLLGNMLDLAQDHLPIHLTALA KCYGNIYRLNCGSTS 5738 AMVVLNNSEIIREALVKKWSDFAGRPYSYTG XDIVSGGGRTISLGDFSEEWKAHRRVTHSALQRCTTDSLHSVIEKQAQHLCQ

VLRDYSGKAVDLSEDFTVASSNVITTLTFSKA

YDKSSAELQKLQECLNEIVSLWGSPWISALDSFPLLR KFPNPPFSRLMKEVARRDELIGKHIEEFK

KSEHKEGGTLTSSLLKCLEPQQGAANHT

TLTDTHVHMTTVDLLIGGTETIAALLNWTVAFLLHRPE VQDKVYEELCCVLDVRYPQYSDRHKLPYLCALISEMLRLRPVAPLAVPHRAIRNS SIAGHFIPKNTIIIPNLYGAHHDPEVWDDPYSFKP ERFLEGGGGSLRSLIPFGGGARLCLGEAVAKMEMFLFTAYLLREFKFLPASKEEPLP ELRGVASVVLKVKPYTVIAHPREQ*

 

>CYP24A1 ctg12249 CN507760.1 69% to human CYP24 76% to fugu CYP24

MRAHLQRAPQILELLKKKTAGLQHCKPTSSVCVLDSKDAAGSAPCAHS LDSIPGPTNWPLFGSLIEVIRNGGLKRQHETL IHFHKKFGKIFRMKLGSFESVHIGSPCLLEALYRKEGSYPERLEIKPWKAYRDMRDEAYGLLIL SEVAADLIKRIGKVNGKMDDLYFELNKWSFET

ICYVIYDKRFGLLQDSVSKEGMDFITAVKT MMSTFGTMMVTPVELHKTLNTKTWKDHTEAWDRIFST AKHYIDKNLQKQSNGEADDFLSDIFHNGNLTKKELYAATTELQVGGVET TANSMLWVIFNLSRNPCAQGKLLKEIQDVVPAGQTPRAEHIKNMPYLKACLKESMR VSPSVPFTSRTLDKDTVLGDYTLPKG TVLMLNSQAIGVSEEYFDNGRQFRPERWLEEKSSINPFAH VPFGVGKRMCIGRRLAELQIQLGLCWILRDYK

IVATDLEPVDSLHSGTLVPSRELPVAFVPR

 

>CYP26A1 U68234

MGLYTLMVTFLCTIVLPVLLFLAAVKLWEMLMIRRVDPNCRSPL PPGTMGLPFIGETLQLILQRRKFLRMKRQKYGCIYKTHLFGNPTVRVMGADNVRQILL GEHKLVSVQWPASVRTILGSDTLSNVHGVQHKNKKKAIMRAFSRDALEHYIPVIQQEV KSAIQEWLQKDSCVLVYPEMKKLMFRIAMRILLGFEPEQIKTDEQELVEAFEEMIKNL FSLPIDVPFSGLYRGLRARNFIHSKIEENIRKKIQDDDNENEQKYKDALQLLIENSRR SDEPFSLQAMKEAATELLFGGHETTASTATSLVMFLGLNTEVVQKVREEVQEKVEMGM YTPGKGLSMELLDQLKYTGCVIKETLRINPPVPGGFRVALKTFELNGYQIPKGWNVIY SICDTHDVADVFPNKEEFQPERFMSKGLEDGSRFNYIPFGGGSRMCVGKEFAKVLLKI FLVELTQHCNWILSNGPPTMKTGPTIYPVDNLPTKFTSYVRN

 

>CYP26B1 NM_212666 87% to fugu 26B1 AI721901 fc26h10.y1,

MLFESFDLVSALATLAACLVSMALLLAVSQQLWQLRWTATRDKS CKLPMPKGSMGFPIIGETCHWFFQGAGFHASRRQKYGNVFKTHLLGRPLIRVTGAENV RKVLMGEHSLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRKIFAKVFSHEALESYLPK IQQVIQETLRVWSSNPDPINVYRESQRLSFNMAVRVLLGFRIPEEEMHCLFSTFQEFV ENVFSLPIDLPFSGYRKGIRARDSLQKSIEKAIREKPLHTQGKDYTDALDVLLESAKE NNTELTMQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSCGLLHD GCLCQGELRLDSIISLKYLDCVIKEVLRLFAPVSGGYRIATQTFELDGVQVPKGWSVM YSIRDTHDTSAVFKDVEAFDPDRFSPERSEDREGRFHYLPFGGGVRSCLGKQLATLFL KLLAVELAGGSRFELSTRTFPRMISVPVVHPTDGLRVKFFGLDSNQNQIMAKSDEMLD

ATV

 

>CYP26C1 ctg13279 ZEBRAFISH EXON 5 HIGHLY VARAIBLE IN LENGTH

MFDHGFCLVSALLSVADAVLPTVLLLAVSRLLWEFRWSITRDKTCKLPLPQGSMGWPLVGETFHWLFQ GSSFHISRREKHGKVFKTHLLGKPLIRVTGAENIRKILLGEHTVVCTQWPQSTRIILGP NTLVNSVGDLHKRKRK VLAKVFSRGAQ*APFIRLQDVVEFDIAKWCNKTGFVEVTSAAESLTFRITVGVVLGMHLK DQQITYLSKALEQLMNNLFSLPIDTPVSGLRK GIRAREILHSAMEKIIEEKLKKQQASDYCDAFDYMLSSARENDYELTMQELK SPAVELIFAAHSTTASASTSLIMQLLRHPDVSERARAELESEGL ITDGHGHCRSRCNGNEEGEAAEKSTSDRRSAINKATYFEAGDKEEGR RSRTHVPYLSLEKLSQLSYLDCVVKEVLRFLPPVSGGYRTVLQTFELN GYQIPKGWSVMYSIRDTHETAEAYQNPEFFDPDRFCVGREESKSERFSYVPFGGGVRR CIGRELALIVLKTLAVELLATADCTLATQTYPRMQTVPIVHPVNGLHVFFNYR

TQGIERNRRESTHI*

 

>CYP27A3_ctg11505 EST = CD283382 chr9:22363585-22376631 (+)

MFSNSLLRTGLFLCKQDCSGIKCLTSMFLNARTTSTLIGGDKQKTMDDLDGPS FLTSLYWLFGKGYFQTTHQMQIEHSKIYGPLWKSKYGPLVIVNVASAHLIKQVLRQ EGRHPIRTDMPHWRGYRKLRNHAYGPLTEM GPEWQRIRSILNPRMLKPKHVSNYTNAINGVVSDFIEKMAKLKTTKGNDVMVYDVAGELYKFAFE GISSVLFETRMGCLNDEIPEETQKFIFSVGEMFRLSPIVILFPKFLWPYMPF

WKHFVAVWDHLFKV ADELVQQKMTEIQEKVKTGSPVEGEYLTHLLISEQMSFTEVLGSITELLLAGVDTVSI TISWALYHLAREPEIQQKLHEEVVSVCPGDKTPSSDDITRMPLLKAIVRETLR LYPVVPANARVVAQNEIVVGDHLFPK

QTLFHLCHFAVSYDETVFPDPFAFLPQRWIREQKQLSQH

PFGSVPFGFGIRACLGRRVAELEMYLLLSR

LIKRYEVRPDPSGKTVKPITRTLLVPATSIDLQFIDR*

 

>CYP27A3_XM_001923888 98% to ctg11505 Danio

MDDLDGPSFLTSLYWLFGKGYFQTTHQMQIEHSKIYGPLWKSKY GPLVIVNVASADLIEQVLRQEGRHPIRTDMPHWRGYRKLRNHAYGPLTEMGPEWQRIR SILNPRMLKPKHVSNYTNAINGVVSDFIEKMAKLKTTKGNDVMVYDVAGELYKFAFEG ISSVLFETRMGCLNDEIPEETQKFIFSVGEMFRLSPIVILFPKFLWPYMPFWKHFVAV WDHLFKVADELVQQKMTEIQEKVKTGSPVEGEYLTHLLISEQMSFTEVLGSITELLLA GVDTTSNTISWALYHLAREPEIQQKLHEEVVSVCPGDKTPSSDDITRMPLLKAIVRET LRLYPVVPGNARVVAENEIVVGDHLFPKNTLFHLCHFAVSYDETVFPDPFAFLPQRWI REQKQLSQHPFGSVPFGFGIRACLGRRVAELEMYLLLSRLIKRYEVRPDPSGKTVKPI TRTLLVPATSIDLQFIDR

 

>CYP27A4v1 BX321915.3 XM_001923045.1 chr9:39232089-39242748 (+)

MAVSFALSSAERLGWCFLRPTTAATGFRRAAGNSAAASVSVQDGHRKLKTEA DLPEIKIFTMLYQMLFKGYLNSVHELQ LYQKQVYGPLWKINAGNLQGISITSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGISYGPFTE EGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLE GIASILFETRIGCLEKEIPAETQEFINSIAQMFTYNMHVALLPNWTRNYLPFWQKYIDGWDGIFKF GTKMINLKMEAIQTRLDTNQEVAGEYLTYLLSSGKMSCKDVYGSVSEVLLAGVDT TSNTMLWALYLLSKDPAAQETLHQEVTKVLKGDRIPTAEEVNSMPFLKAVIKETLR LYPVVPVNSRLIAESEVIIGEYLFPKK TTFNLFHYAISHDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALAR LIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVERQKTET*

 

>CYP27A4v2 BC095716 98% to CYP27A4v1

MAVSFALSSAERLGWCFLRPTAAATGFRSAAGNSAAAS VSVQDGHRKLKTEADLPEIKIFTMLYQMLFKGYLNSVHELQLYQKQVYGPLWKINAGN LQGISITSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGISYGPFTEEGEKWYKLRAV LNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLEGIA SILFETRIGCLEKEIPAETQEFINSIAQMFTYNMHVALLPNWTRNYLPFWQKYIDGWD GIFKFGTKMINLKMEAIQKRVDTNQEVAGEYLTYLLSSGKMSCKDVYGSVSEVLLAGV DTTSNTLLWALYLLSKDPAAQETLHQEVTKVLKDDRIPTAEEVNSMPFLKAVIKETLR LYPVVPVNSRLIAESEVIIGEYLFPKKTTFNLFHYAISHDEKVFPEPQKFKPERWLRD GRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALARLIKLFEMRPDPTVGEVKANFRS VLVPNKKVNLHFVERQKTET

 

>CYP27A5 BC117585.1 BX321915.3 chr9:39213157-39219252 (+)

MAVCFALSSAERLGFGFLRPTAAATGFRRAAGNAAAASVSVQDGHRKLKTEA DLPEIKIFTMLYQMLFKGYLNSIHELQ IYQKQVYGPLSKINSGNLQGISISSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGIGYGPFTE

EGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLE XIASILFETRIGCLEKEIPVETQEFINSIAQMFTYSMHVALLPNWTRNYFPFWQKYIDGWDGIFKF GTKMIDMKMEAIQKRVDTNQEVAGEYLTYLLSSGKMSSKDVYGSVSELLLAGVDT TSNTMLWALYLLSKDPAAQETLYQEVTKVLKDDRIPTAEEVNSMPFLKAVIKETLR LYPVVPVNSRLIAETEVVIGEYFFPKK TTFNLCHYAISHDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALAR LIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVERQKTET*

 

>CYP27A6 BX321915.3 XM_001333968.2 (partial) chr9:39205612-39210826 (+)

MAVCFALSSAERLGWCFLRPTAAATGFRSAAGNAAAASVSVQDGHRKLKTEADLPEI KIFTMLYQMLFKGYLNSVHELQ LYQKQVYGPLWKINAGNLQGISISSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGISYGPFTE EGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLE XIASILFETRIGCLEKEIPAETQKFINFIAQMFTYSMHVALLPNWTRKYFPFWQKYIDGWDGIFKF GTKMIDMKMEAIQKRVDTNQDVAGEYLTYLLSNGKISRKDVYGSVSELLLAGVDS TSNTMLWALYLLSKDPEAQETLYQEVTKVLKDDRIPTAEEVNSMPFLKAVIKETLR LYPVVPVNSRLIAETEVVIGEYFFPKK TTFTLCHYVISRDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALAR LIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVERQKTET* 49254

 

>CYP27A7 BC055637.1 BX321915.3, BC055637 chr9:39194579-39203929 (+)

MAVCFALSSAERLGIGLGFLRPTAAATGFRRAAGNAAAASVSVQDGHRK LKTEADLPEIKIFTMLYRLLFKGYLSRMHELQ LYEKQLYGPLYKINVGNFQSVALNSVDLLEELLRKDEKFPSRGDMTLWTEYRDMKGIGYGPFTE EGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNKLYRFSLE GISSILFETRIGCLEKEIPAETQHFINSIAQMLTYSMPVVFMPNWTRNYLPFWQRYIGGWDGIFK FAGKMIDMKMEALQKRVDANQEVAGEYLTYLLSNGKMSSKDVYGSVSELLLAGVDT TSNTMLFALYHLSKDPETQDILYQEVTNVLKDDRIPTAQEVNTMSYLKAVIKETLR LYPVVPMNARLIAENEVVIGGHLFPKN TTFTLCHYAISRDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRGCVGRRIAELEMYLALAR LIKLFEIRPDPTVGEVRSLNRTVLAPDRKVNLHLVERKKTEA*

 

>CYP27B1 ctg10726 72% TO 27B1 FUGU from multiple contigs

MMMVLHQALKVTGRSALPLLRFAERWADVIRAPPTPQVKTLEQMPGPSPARFIRDLFMKRGFS

RLHQLQ

LEGRQKYGPMWKASFGPILTVHVAEPELIQQVLRQEGQHPMRSELSSWKDYRALRGEG

YGLLT

SEGEEWQCVRSLLSKHMLRPQAVEAYDGALNAVVSDLLQKLKLRSQESSSRIVSDISAEF

YRFGLEG

ISSVLFESRIGCLDAVVPVETERFIQSINTMFVMTLLTMAMPQWLHRLLPKPWDTFC

RCWDVMFEF

AKGHIDQRLQQEKQKLECGEQLEGRYLTYFLSQAGLPLTSVYSNVTELLLAGVDT ISSTLSWSLYELSRHPDVQTALRXEVLSVMKGRRSVPQASDVAAMPLLKAVVKEIL RLYPVIPANARVINKDIEVGGYVIPKN

TLITLCHYATSRDP

QQFRDPDSFRPQRWGDRSDRSHPYATVPFGVGKRSCIGRRIAELEVYLALSR ILMHFTVEPARQDDTVHPMTRTLLVPERQIDLRFTER*

 

>CYP27C1 ctg14633 70% TO FUGU CYP27C1

MARKNLLQESCRQLLIQTHGLHKSVASGSLEIAAHSQADLKEESAVSPAEEVQ KAARVKSLKEMPGPSTVANLLEFFYRDGFSRIHEIQ MEHAKKYGKIFKSRFGPQFVVSIADRDMVAQV

LRSESATPQRGNMESWKEYRDLRGRSTGLISA

EGDEWLKMRSVLRQLIMRPRDVAVFSSDVT

DVVADLVKRVKTLRSQQDDSQTVLNINDLFFKYAME GVATILYETRLGCLENEIPKMSQEYITALHLMFSSFKTTMYAGAIPKW LRPIIPKPWEEFCSSWDGLFKFS IHVDKRLSEIKKQMEKSEEIKGGLLTHMLVTREMNLEEIYANMTEMLLAGVDT TSFTLSWSTYLLARHPTIQQQIFEEVDRVLGGRVPTGEDVPYLPLIRGLVKETLR LFPVLPGNGRVTHDDLIVGGYLIPKG TQLALCHYSTSMDEENFPRPEEFRPDRWIRKDASDRVDNFGSIPFGYGIRSCVGRRIAEL

EMHLALTQ

LLQNFHIEVSPQTTEVHAKTHGLLCPGASINLRFTDRK*

 

>CYP39A1 ctg9833 48% to 39A1 AL929058.4 96727-71438

MEWITLILTVSVVIISFHLLFGKSHPNAPPCIRGWIPWFGAAFEFGKAPLHFIQQARAK YGPVFTVVAAGKRMTFVTLNEDFRVFFTSKDVDFEQAVQEPVHNT ASISKDNFFESHPTCSAIIKGRLTPGNTAMLSPHLCEEFNDHLESLGSEGSGQLNELIK SVMYPSVMSNLLGRCNSPSSALSRQEFLEKFTTYDEGFEYGSQLPEMFLK

EWSNSKHWLLSL LRKMVIKSEETLYSESDRK

TLLQHLAASISEQYLPNYGLLLLWASLANAIP

VTFWAVAFILSNPTAYKIVMDQINSVLGRQG KQKTKVTLDDLQQMPYVKWCIMEAIRLRAPGAITRKVVRPLKLX NYVIPPGDMLMLSPYWAHRNPKYFPDPEDFKP

ERWETADLEKNVLLEGFVAFGGGKNQCPGR

WYAIMELHMFVALILYKFEFAQLDPMPK

 

>CYP46A1 chr20:4947279-4961022 (+) XM_001331518.2 (8 aa DIFFS) BC109436.1

MIFEWVLYIVFSLLAAVFTAFLGYCLYIHHLHQKYDHIPGPPRD

SFLLGHSSSLTKAVYSDNNLIHDLFLYW

AEKYGPVYRINTLHYVTIVVYCPEATK

TIMMSPKYTKDPFVYRRVFNLFGKR

FLGYGLITAVDHDIWYRQRRIMDPAFSSS YLRSLISTFDEMSERLMDKLEEIANNKTPAVMHDLVNCVTLDVICK VAFGVDLNFLTQKDSPFQNAVELCLKGMTFDVRDPLFR IIPKNWKLIQQVREATELLRKTGEKWIQNRKTAVKNGEDVPKDILTQILKSAGM QNVTSTEDFEQMLDNFVTFFMA

GQETTANQLSFAIMELGRNPEIYKR

AKAEVDEVLGTKREISNEDLGKLTYLSQ

VLKETLRLYPTAPGTNRWLHEDMVINGIKIPGGCSVM

FSSYVSQRLEKFFKDPLKFDPERFDVNAPK

PYYTYYPLALGPRTCIGQVFSQ

MEAKLVLAKLLQRFEFSLVPGQSFDIKDNGTLRPKSGVICNIKQCS*

 

>CYP46a-de1b2b3b4b5b chr20:4973129-4977542 (+)

MISEWIFYIILYLLAAVFTAFFAYCLYVHHIHQKYDHIPGPPRD

NFLLGHSPSLTKALYSDDSLIYDLFLQW

AEKYGPVYRINTLHYVTIVVYCPEATK

TIMMSPKYTKDPFVYRRVFNLFGKR

FLGYGLITAVDHDIWYRQRRIMDPAFSSS

 

>CYP46A2 BC055161 cDNA, N-term in seq gap, chr5:73217357-73232610 (-)

MVSEWILYIIFYLLSAVFTAFLAYCLYIHHLHQKYDHIPGPPRDNFLLGHSPSLTKA MYSDDSLIHDLFLQW

AEQYGPVYRINTLHYIAIVVHCPEATK

TILMSPKYAKDPFSYSRLFNLFGKRFLGNGLVTAVDHDIWYRQRRIMDPAFSSSYLRSLI STFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICKVAFGVDLNFLTQKDSPFQ NAIELCLNGMALDARDPLFRIFPKNWKLIQQIRDAAVLLRKTGEKWIQNRKTAVKNGE DVPKDILTQILKIAEEENVNSSEDLEQMMDNFVTFFIAGQETTANQLSFAIMALGRNP EIYKRAKAEVDEVLGTKREISNEDLGKLTYLSQVLKETLRLYPTAPGTNRWLHEDMII NGIKIPGGCSVMFSSFVSQRLEKFFKDPLKFDPERFDENAPKPYYCYYPFALGPRTCL GQVFSQMEAKVVLAKLLQRFEFSLVPGQSFDIKDTGTLRPKSGVICNIKQCS*

 

>CYP46A4P 94% to CYP46A2 missing N-term, chr5:73235997-73241459 (-)

YLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICK

VAFGVDLNFLAQKDSPFQNAVELCLNGMTVDLRDPFFR

LFPKNWKLIHQIRDAAELLRKTGEKWIQNRKTAVKNGEDVPKDILTQILKSAGM

EEENVNNTDDLEQMLDNFVTFFIA

GQETTANQLSFAIMALGRNPEIYKR

AKAEVDEVLGTKREISNEDLGKFTYLSQ

VLKETLRLYPTAPGTNRWLHEDMVINGIKIPGGCSVM

FSSYVSQRLEKFFKDPLKFDPERFDVNAPK

PYYCYFPFALGPRTCLGQVFSQ

MEAKVVLAKLLQRFEFSLVPGQSFDIKDTGTLRPKSGVICNIKQCS*

 

>CYP46-se2[4,15] Danio exons 14,15 chr5:73126154-73127267 (+)

PYYTYYPFALGPRTCIGQVFSQ

MEAKVVLAKLLQRFEFSLVPGQSFDIKDTGTLRPKSGVICNIKQCS*

 

>CYP51A1 AY496939

MTILEVGSQLIESAVLQMSLTSVLLTASVFTLTLGYISKLLFTQ HSSEHTKYPPHIPSSLPFLGQAVAFGRSPIEFLEKAYEQYGPVVSFTMVGKTFTYLLG SDAAALMFNSKNEDLNAEDVYARLTTPVFGKGVAYDVPNPLFLEQKKMLKTGLNIAQF KQHVEIIEEETKDYFRRWGESGERNLFDALSELIILTASRCLHGCEIRSLLDERVAQL YADLDGGFTHAAWLLPGWLPLPSFRRRDRAHLEIKKIFYNVIKKRREDTEKHDDILQT LIDATYKDGRPLSDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLARDRALQERCYSEQK SVCGEELPPLHYDQLKDLSLLDRCLKETLRLRPPIMTMMRMAKTPQKVGEYTIPPGHQ VCVSPTVNHRLQDTWAERLDFDPDRYLHDNPAAGEKFAYIPFGAGRHRCIGENFAYVQ IKTIWSTLLRMFDFELVDGHFPPVNYTTMIHTPHNPIIRYTRRNAQPQQ