ࡱ>  bjbjв 2к_к_oy 88888LLL8L   hjjjjjj$8     88T    88h  h   :G  T0 = =  = 84                =          X : Cytochrome P450s from duck-billed platypus 55 sequences were retrieved from Entrez protein by a search for anatinus AND P450. Two were false positives. Many are partials and incomplete sequences. There is some error in assembly. 79 sequences were retrieved from the nucleotide section of Genbank by a search for anatinus AND P450. These matched the 53 sequences found in Entrez protein. Many of these genes need additional work. D. Nelson Jan. 22, 2008 >CYP1A1 gi|149639131|ref|XP_001511800.1| PREDICTED: similar to cytochrome 1A1, partial [Ornithorhynchus anatinus] 71% to CYP1A1 XM_001511750 ETRGLLQASSPGLVSVTEILLASAIFFLAFWIIGSLSEKVPHGMKSPPGPWAWPLIGNILELRKDPHLAL TRMSQVYGDVMQVQIGTTPVLVLSGLETLRQALVKQGEDFMGRPDLYTFQHIGDGESLSFSTDSGEVWVA RRKLAQNALKTFSLASSPSSSCTYLEEHVSKEAVSLIGKFQELMKKRGSFDPYRYVMVSVANVICAMCFG KRYDHNDQELLSVVSLSDKFGEFAASGNPADFIPILRYLPNHALRNFKDLNQKMVAFLQKMLMEHYRTYE KNQVRDITDSLIEHCQDKKLDENANVQLSDKKIVNVVLDLFGAGFDTITTSLSWSLMYLVKYPEVQKKIQ EELDMVIGRGRMPRLSDRSLLPYTEAFILESFRHSSFIPFTIPHSTTRATTLNGYYIPKGRCVFVNQWQI NHDPELWEDPSAFRPERFLTQEGTKINKALSERVTMFGLGKRKCIGETIARWEVFLFLTILLQQIEFSVQ SGGKLDMSRIYGLAMKHPRCEHFQVHPRF >CYP1B1 gi|149408684|ref|XP_001510708.1| PREDICTED: similar to cytochrome P450 1B1 [Ornithorhynchus anatinus] 73% to CYP1B1 XM_001510658, NW_001594475 complement 1323261-1346148 EST EH001533, EH001420, EH000829 Cyan does not match MAGQKRDRCSRPLAAGWFSDLLGHHSIARHDRPVHWNQSCGVKFSCAAYRSASECPFSGDEYIKHDEMKL QFSDDRFAETTEDRRAHVMPVKLRQVYQRQTPTGQNKMFLLLKTSFTPVNQQQTYLLGHLVSREIKEKED IAKGLKVWFLGFFFF LIVFRFPKVQAEVQEELDRVVGRERLPCMADQPTLPYLMAFLYEAMRFSSFVPLT IPHATTSDTSILGFHIPKDTVVLINQWSVNHDPVTWRNPEDFCPARFLDKNGFVDKDLASSVMIFSLGKR RCIGEELSKLQLFLFTAILAHQCNFIADPDEIAKVKFSYGLTIKPKPFKINVTLRESMELLDKAVQRLQE EEDSQ >CYP1D1 gi|149633525|ref|XP_001506106.1| PREDICTED: hypothetical protein [Ornithorhynchus anatinus] 70% to CYP1D1/CYP1A8P XM_001506056 MAKTKALLPTHFQRVKKGADPHANFFAEVEYSLYKGESLQFVVISPHLIYLGRNIARVGGNVSCRGYAPQ NCAVHRLHSVVKNNYQLAKFSPALAVLHVTVVMDLMAEAGRTAVDLTGIRGQVSQPFGTFFPGLGRAEDL VIQLFVQNPRGSFGGNEGRSLRGRRTEVARGRRKLQCPVISPCLLASYFEGQKPPSPPGPWALPVIGNLL QLGEHPYLSFIEMRKKYGDVFLIKLGMVPVVVVNGMEPVKRVLFQDGENYAGRPNMHTFSFFANGKSLSF STNYGDSWKHHKKMAINALKSFSKAEAKSSTCSCLLEEHVCGEVSELVKIFTELTATQGNFDPRGSLTCA VANVVCALCFGKRYEHTDEKFLKVIKINDDLLKASSAVNPADFIPCFRYLPLRVVNAPREYYHMLNQFIM QHVQEHYVTYDEGYLRDITDALISICYDKNSTGKTPILPDDTIISTVNDIFGAGFDTVSTCLNWSFLYLI NYPEIQTKIQAEIDGNIGLKPPRFEDRKNLPYTEAFINEIFRHTTFLPFTIPHCTTADTILNGYFIPQKT CVFVNIYQVNHDETLWEKPDLFRPERFLNENGELNKGLVEKVLIFGLGIRKCLGEDVARNEIFIFITNVL QHLKLEKCSGAQLDLTPVYGLSMKPKPYHIKAEPRF >CYP2A.a gi|149632665|ref|XP_001511572.1| PREDICTED: similar to LOC494798 protein [Ornithorhynchus anatinus] XM_001511522 46% to CYP2A6 MAVVKVLLHSLSASFLFYGVIVGLVVIYILTSSKRSRGKLPPGPPPLPIIGNLNLVDLNKLYQSLMELSE NYGSMFTVHLGPRKVVVLAGYDAIKDALFNNSEAFGDRPEIPIFQKVTGGHGIGFSNGDTWKAMRRFALS TLRDFGMGKKSIEAKIQEELNSLVKYFQSHQGKPFDTKIILNNAVSNIICSILFGDRFEYDDPEFLHLLQ LLSDNTKLMGSSMVQLYNFYPFFGFLIGAHKTVVRNIQEITSFIQKLFKEHILNFSPNHLTGFVDAFLLK QQQESKNPQTEFHNKNLLFSTLDLFAAGTETTSTTLRWGLLLMMKYPEIQRRVHEEIDKVIVLGQVPSVE DRKKMPFTDAVIHEMQRFADIVPMGLSRSPTKDIHFRGFVIPKGTEVIPLLSSVFCDPSHWATPYQFNPS HFLDAAGNFVRKDAFIPFGLGRRACAGEGLARMELFLLFTGLLQKFTFQAAPEVDKADLDLTASVGFTLT PKPHLVCALPREEAKSQG >CYP2A.a AAPN01409126.1 MAVVKVLLHSLSASFLFYGVIVGLVVIYILTSSKRSRGKLPPGPPPLPIIGNLNLVDLNKLYQSLME 27985 LSENYGSMFTVHLGPRKVVVLAGYDAIKDALFNNSEAFGDRPEIPIFQKVTGGH 27818 GIGFSNGDTWKAMRRFALSTLRDFGMGKKSIEAKIQEELNSLVKYFQSHQ GKPFDTKIILNNAVSNIICSILFGDRFEYDDPEFLHLLQLLSDNTKLMGS (gap) QESKNPQTEFHNKNLLFSTLDLFAAGTETTSTTLRWGLLLMMKYPEIQSK >CYP2A.b gi|149553936|ref|XP_001507121.1| PREDICTED: similar to cytochrome P450 CYP2A23, partial [Ornithorhynchus anatinus] 67% to CYP2A13 cattle XM_001507071, NW_001725301 <785-4347 MIIASVSLLTSLSVLNAWESTSNRVGRLIPXXXPLPFFGNYLHLDINQMSNSLIKVSRKYGPVFTVHLGP RRVVVLCGYQAVKEALVDQGEEFSGRGEQATFNWLFQDFGVTFSQGERAKLLRRFSIMTLRDFGMGKRGI EERIQEEARFLNESLRETKGSPIDPTFFLSRAVSNVISSIVFGDRFDYQDQQFLSLLQMINTSFQFSASS AGQ >CYP2A.d gi|149553938|ref|XP_001507160.1| PREDICTED: similar to cOR9K3 olfactory receptor family 9 subfamily K-like, partial [Ornithorhynchus anatinus] 71% to CYP2A6 XM_001507110 NW_001725301 6944 >11616 KVHEEIGRIIGRNRPPRLEDRAQMPYTEAVIHEIQRFSDIIPMSIAHCVMKDTKFRGYLIPKGTEVFPML GSVLRDPQFFSAPKAFDPGHFLDAKGQFKKSDAFMAFSVGKRYCFGEKLARTELFLFLTTILQNFHFKPL PRTADIDISPKIVGFATIPHNYDISFLPR >CYP2A.c gi|149510764|ref|XP_001518574.1| PREDICTED: similar to cytochrome P450 CYP2A23, partial [Ornithorhynchus anatinus] 69% to CYP2A6 XM_001518524, NW_001684624 12334>14763 MLAAGLVTELLLACVSILVLLSIWQQWKDRSKMPPGPPPLPFIGNLLHLDPRQMSDSLI KMSRKYGPVFT MHLGPRPVVVLCGYQAVKEALVDQGEEFSGRGEQALFNWLFKDFGVIFSQGERAKQLRSFSITTLRDFSV GKRGIEERIQEEAQFLI ESLRDTKGAPIDPSFFLSRAVSNVISSIVFGDRFDYEDEQFLSLLQMISRGFQ FIASPIGQLFDSYHCVMKYLPGPQHQAMKQLQGLEQFIAEKVRENQRTLDPNSPRNFIDSFLIKMQEDEE NE >CYP2A.e gi|149505993|ref|XP_001513381.1| PREDICTED: similar to cytochrome P450 2A13, partial [Ornithorhynchus anatinus] 74% to CYP2A6 XM_001513331, NW_001680185 <4268-11644 TALNLFFAGTETVSTTLRYGFLLLMKYPEVEAKVREEIERVIGHNRPPRFEDRAQMPYTEAVIHEIQRVS DIIPMSLAHRVMKDTKFRGYLIPKGTEVFPLLSSVLRDPQFFPNPEAFDPGHFLDVNGQFKKSNAFMAFS VGKRYCFGERLARTELFLFLTTILQNFRFKSPLRTEDIDISPKLVGFATIPRNYEISFLPR >CYP2B gi|149515309|ref|XP_001520133.1| PREDICTED: hypothetical protein, partial [Ornithorhynchus anatinus] 66% to CYP2B6 XM_001520083 KVQEEIDQVIGQDRPPGLEDRTRMPYTDAVIHEIQRFSDLLPLGVPHIVTQDTHFRGYFLPKGTDVYPLL SSVLHDPRHFKRPDSFDPGHFLDARGNFKKSEAFLPFST >CYP2C.a gi|149570722|ref|XP_001505917.1| PREDICTED: similar to Cytochrome P450, family 2, subfamily c, polypeptide 70, partial [Ornithorhynchus anatinus] 42% to Cyp2c65 mouse XM_001505867, NW_001740623 7954 >11421 ERQQPESEFTLENLKMCVYDLFLAGTETVSITLRYALLTLLKYPKIDPQSHRESETTPRHLMIDHNKGGE HRTELWDRALHSSPADRASVSFSALPAPTSCSCPPDTRAGPDQTPSLPPPNSTPALFQGTTVYPVLGSVL NDPQQFPEPERFAPEHFLDAKGAFKKSGAFMVFSAGKRNCVGEGIARMELFLFLTTLLQNLRLSPPPGVR AVDVQPGISGVANLPPPFQICVTPH >CYP2C.b gi|149505995|ref|XP_001513402.1| PREDICTED: similar to transmembrane protein 132B, partial [Ornithorhynchus anatinus] Cyan does not match XM_001513352, NW_001680185 11679 >19947 MGREEVGFPDATTAFGSEPRVSGWTVGRGLRRDPGTSSGHSAGRGEGGPVKTEKGRRGWGGYTGHGPERR PAWGAPFSGPLEVSGFGRATEPGPYRPESCSSSPSGTDSFTPIPRDGRMARMTLQ 52% to CYP2C19 TPVPLEGSRRLLDGR VPCRQLRARYGPVFSVHFGEERAVMVLGYEEVREVLLERGDEFLDRGSFPSADRTNRGLGVIMSNGKRWR DLRRFSLSALRDLGMGKRSLEERVQDEAQCLLEEFRKTQ >CYP2D gi|149416604|ref|XP_001516872.1| PREDICTED: similar to cytochrome P450, family 2, subfamily D, polypeptide 6 [Ornithorhynchus anatinus] XM_001516822, NW_001597728 208653-217626 MAGQGEHREEEEGLGGPVHGPGAPAAPRPAPFLR 69% to 2D8P2 QLREKFGDVFSLQFSWTNVVVLNGLAAVKEALVQRSEETAGRPPLVTYDHLGFGPNSEG RSPRGRRAVVPERARGSSARQGGAAAFI 68% to 2D6 LNAVPWLVTIPGLPQRIFR AQKAFITLLDTFIEEHKKTRDPALPRDLTDAYLEQVDQAKDDPGSSFNDRNIRIVVTDLFTAGTETTSTT LKWALLFMLLHPDVQSRVQVEIDQVIGRDRRPTMADQAKMPFTNAVIHECQRLGDIIPIGLPHLTLRDTQ VQGFFIPEGTYLILNLSSVLKDDTVWEKPHQFYPEHFLDRDGRFVKPEAFLPFSAGRRVCLGEPLARXEL FLFFTCAPAALHLG >CYP2E1.a gi|149570232|ref|XP_001517616.1| PREDICTED: similar to cytochrome P450, partial [Ornithorhynchus anatinus] 64% to CYP2E1 XM_001517566, NW_001740221 <3802..3961,6655..>6804 LAKEYGPVFTLYLGSKRAVVLHGYEVVKEVLLDHKEEFVGRADVPGFEVHKNLGIIFNNGNLWKQTRRFS LTTLRDWGMGKKGNEERIQEEAQRLVKELRNTN >CYP2E1.b gi|149435890|ref|XP_001520913.1| PREDICTED: similar to Cytochrome P450 2E1 (CYPIIE1) (P450-J), partial [Ornithorhynchus anatinus] 63% to CYP2E1 XM_001520863, NW_001615134 <9770>22579 YRKALVGQESSVSGHWRPILVFFLSGSGIPSQIQISCHRAERNGGYTASQIDFRILYNYLLFHVSINALP LDPTSILSSAPCNVISRILFQKHFDYKDKEFLRLMQIIREIFYLLSSPWIQIFQAFPSFLRYVPGTHHKL INNIAKMKKFVSEQVKEHQESLDPNHPRDFTDCLLIEAEKQKQDPQLGFSMENTTITVADLLFAGTETTS TTLRYGLLILLKYPEVE >CYP2G.a gi|149524993|ref|XP_001516537.1| PREDICTED: similar to Cytochrome P450 2B11 (CYPIIB11) (P450 PBD-2), partial [Ornithorhynchus anatinus] 56% to 2G2P XM_001516487, NW_001698049 3260>10856 MAWAVSPPWLPSSAGPFLLILVLFLLLLLLLFRRGHPPARLPPGPRALPILGCLPQMWGVPLLDFLLKVN GISFSQGERWRTLRRFSVATLRDLGMGRRGIEERVQEEVRCLLEEFRKTRGHPFDPTFPLRRSISNVICS VVFGRRFDYADPEFGTLLRLLNDNLRRVDSVSVRLYSLFPGLLRHLPGPHNLLFEVFEEQKRFVARIVKE HEASLDPAEPRDFMDAFLIRMQQDRKNPLSEFHLENLLVTALDLFFAGTETTSTTLKYGLLLLLKHPQIT ERVQEEVDSVIGQNRRPALEDRARMPYTDAVIHEIQRFIDIMPLGVPHAVTRDTCFQGYTIPKGTMVFPL LHSVLHDPDHFPDPAVFEPKRFLTEDGRFQRNAAFLPFSAGEHGVGAGAGGGVVHR >CYP2G.b gi|149613548|ref|XP_001521133.1| PREDICTED: similar to MGC82323 protein, partial [Ornithorhynchus anatinus] 69% to 2G2P XM_001521083 LYDMYSSIMRYLPGPHNQIYNLIEELKNFVAEQVRGNRESLDSSNPRDFIDCFLIKMEQ SVWHLIAVLRYPSPS 69% to 2G2P AKVHEEIDRVIGRERIPGIEDRMGMPYTDAVIHEIQRVTDIVPMGVPRAVTRDTHFRGYILPK >CYP2R1 gi|149621252|ref|XP_001518489.1| PREDICTED: similar to cytochrome P450, family 2, subfamily R, polypeptide 1 [Ornithorhynchus anatinus] 74% to CYP2R1 XM_001518439.1 NW_001784500 10815-23103 MPLLLLWYLQIVIITILVLLSAYYVPAGLSRLKWEEYGPVFTFLGSANSVLLLRLLNSRYGLGWTEHRRL AVNSFRSFGWGQKSFQTKMATEVKYFLSAVATYKGTPFDPKQLVTGAVSNVSNVILFGGRFSYEDAGFRR MMEMFSENVELAASPTAFLYNAFPAMGLLPFGKHRRLFENAARVYDFLSGIIERVSGNRWPRSPKHFIDA YLDEMDREGKDPDSTLSRENLIFALGELIIAGTETTTNVLRWAVLLMALYPNIQGQVQKEIDQRVGPDRA PTLEDKPQMPYTEAVLHEVLRFCNIVPLGIFHATSKDTVIRGYSIPQGTMVITNLYSVHFDEKYWRNPEV FYPERFLDSRGQFVKNEALIPFSLGKRHCLGEQLARMEMFLFFTGLLQQFHLRFPNEPVSPLKPKLGMTL QPRPYLICAEKR >CYP2U1 gi|149614989|ref|XP_001517862.1| PREDICTED: similar to cytochrome P450 [Ornithorhynchus anatinus] 79% to CYP2U1, N-term does not match XM_001517812.1 NW_001778999 3518-18727 GIVFAPYGPVWKQQRKFSHSTLRHFGLGKLSLEPKIIEEFRNV KEEMQKHGAAPFDPLPVIGNAVSNVICSLCFGRRFDYTNGEFKKMLSLMSRGLEISTSNPILLINVCPWL YYLPFGPFKELRQIERDITAFLKRLIREHRESLDRTAPRDFIDMYLLHMEEEQKRDGDSSFNEDYLFYIV GDLFIAGTDTTTNTVLWCLLYMSLNPDVQ (1) EKVHQEIDRVIGRDRAPSLTDKVHMPYTEATIMEVQRMTVVVPFSIPRMTTEET (1) VLLGYTIPKGTVILPNLWSVHRDPAIWEEPDNFLPERFLDEQGQLVKKETFIPFGL (1) GKRVCMGEQLAKMELFLMFTCLMQSFTFAWPEGSGKPFLYGRFGLTLAPHPFNLIISKR* >CYP2W1 gi|149632667|ref|XP_001511639.1| PREDICTED: similar to cytochrome P450, family 2, subfamily W, polypeptide 1 [Ornithorhynchus anatinus] 58% to CYP2W1 XM_001511589.1, NW_001794053 202015-222490 MRNSYRTISSLLLPVLPLLVLLCVCRLSVVWWKEPGCIQCPCSVLALTNISSIQPLIHPHTTFETLNPFA PGCILQTAYSTFSEVSKEGGVLLAFSKNKYKPCSQGQLERQPLWLLGSHLSVQNMNLFIRLLSDPVVVFL LGVLAFWVLRHFSTQSGRSIFKLPPGPQPLPLIGNLHLLDWRRQDKSLMKISEKYGPVFTVQFGLKKMVV LTGYEAVKEALVNFADEFADRPPIPIFYQIQHGHGIFFSSGELWKTTRKFTISSMHKLGMGKHSMEEKII EEFHCLVELLESFKGEPFRLKLFNKAPTNVTFTLLFGERFDYQDPTFVTLLRLIDEIMVLLGSPILQLFN FYPFLGFLLKSPKMILVKIEEVRVILRHYMKMSRQQTDRGNVQSYIDALIQKQEAMNKETLFHDANIVAS VLDLVMAGTETTSTTLQWAILLMMKYPKIQAKVQEEIGQVLSSGRLPRYEDHKDLPFTNAVIHEIQRFVT LLPHVPHCLSVDIHFRDFFLPKGTPVIPLLTSVLLDKSQWETPNVFNPNHFLDAEGNFVKKEAFLPFSTG RRVCVGESLAKMELFLFFTSLLQRFTFQPPPGTRHSDLDITPEATFTMRPQPQLAHAVPRA >CYP3A.a gi|149409184|ref|XP_001512936.1| PREDICTED: similar to post-synaptic density protein 95 [Ornithorhynchus anatinus] 55% to CYP3A5 XM_001512886 NW_001594494.d 3666753-3681977 MSSILNFSIETWILLGTFLALMILYGIWPFRVFTKSGIPGPRPVPFFGNILEYSQGIIEFDKKCFQKYGK IWRLFEGRQAMVAVLDLEIIKTVLVKEVFSSFTNRRRIGIEGIMEESIIGAEDEQWKELRILISPTFSSG KLKEMLRIMIHYGEILVKTIWKKAEKNQNVIVKDYYGAYSLDVITSTSFGVDVNSLNKMNDTYFKEVKKL SSVDFFSPLLALTSIFPFITPLLNLLDISLFPSDSVEYIKRFVHKIRESRHQDNQQHRADLLKLLLDSQN PKEGLKGKKGLSDTGILAQAVAFVFAGYETTSSALSFISYNLATHPDVQQKLQEEIDKVLPNKSPLTYDA IVQMEYLDMVINETLRLYPIGPRLERMCKKTLEINGLTIHKGTCVVIPIAVLQHDPNYWTEPDEFRPERF SKEMREKRDPYTFIPFGVGPRNCIGMRFALLNMKVAIIGLLQNFSLRTCQETQIPLELNSMGFLTPKKPI VLQFIPRADTKSQD >CYP3A.b gi|149409182|ref|XP_001512909.1| PREDICTED: similar to apoptosis inhibitor survivin [Ornithorhynchus anatinus] 57% to CYP3A4 XM_001512859 NW_001594494.c 3638802-3657824 MSSIFSFSIETWILLGTFLTLMILYGIWPYGVFTKRNIPGPWPVPFLGNIQEYSQGLMVFDKKCSEKYGK IWGLYEGRQAIIAVLDLDIIKKVLVKEVFSSFTNRRNTGIEGILELAVSSAEDEHWKELRTLMSRTFTSG KLKEMLPIMTHYGEVLVRNIWRKAEKNENVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDTFVKEIKKI SSIDFFSPLFALISTFPFMIPLLKLLNINLFPNDSVEYFKRFLHKVKERRHQDNQQHRVDFLQLMLDSQN PKEGSKGKGGLSDAELLAQAFAFIFAGYETSSNTLSFISYNLATHPDVQEKLQAEIDTVLPNKSPLTYDA LVRMEYLDMVINESLRLYPISSRLERMCKKTTEINGLTIPKGTCVVIPLFILQKDPNYWLEPDEFHPERF SKEMRDKRDPYTFMPFGAGPRNCIGMRFALLSIKVAMIGLLKNFSLRTCQETQIPPEINSFGLLTAKKPI VLRYIPRADTKIKD >CYP3A.c gi|149613390|ref|XP_001520705.1| PREDICTED: similar to cytochrome P450 3A80, partial [Ornithorhynchus anatinus] 56% to CYP3A4 XM_001520655, NW_001777588 3140 >20312 NLRLNGGLDSSLTIAEYHTWKRIRTIVSPAFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIF GSYSLDVVTSTSFGVDIDSMNNPNDPFVKQINKLLSFTFLSPLILLTVVCPFLVPVFEKMNLSLFPREFL EFFVGVTRNFKEKRQKGVHTGRVDFLQLMVDSQSSDSNSEPSEKNHSYKEMTDTEISTQAIIFIFAGFET TSSTLNFVSYNLATHPEVQKKLQEEIDSILPNKASPTYESISQMDYLDMVVQETLRLFPPGGRIERVCKE TIQIKGLTIPKGTVVIIPAFVLHRDPEHWPEPEKFLPERFSKEEKASHNPYVFLPFGAGPRNCIGMRFAL LNMKAALIHLLQNFSVEPCKETPMPLELDSTGFMKPKKPIILKLVPRSGVDSED >CYP3A.d gi|149409180|ref|XP_001512885.1| PREDICTED: similar to Cytochrome P450, partial [Ornithorhynchus anatinus] XM_001512835 NW_001594494.b <3597721-3635650 55% to CYP3A4 SMILFILMILTYGIWPYGVFTKLRIPGPRPIPFLGNILDYSQGMDEFDKKCFQKYGKIWGLYEGRKAKIA VLDLDIIKSVLVKEVFTNFTNRQMAGIEGIMSESIFSAKDERWKELRTLVSPTFTSGKLKEMVPMMIQYG EVLVKNLQNKVEKNQNVTIKDYFGAYNLDVITSTSFGVDIDNLNKMNNTFVKEIKKLTSINFFSPLFALI SVLPFMIPLLKLLNINTFPNDSVEYFKRFMDKIKERTQQGNPQQRMNFLQLMLDTQNPKEGLKNKGGIIS QKGLSDAEILAQAFSFIFAGYETSSTTLSFISYNLATHLDVQKKLQEEIDEVLPNKAPLTYDALVQMEYL DMIINETLRLYTVGSRLERICKKTMKINGLTIPKGMTVVIPVSCLHSDPNYWVNPDEFHPERFSKEMRDK RDPYTFMPFGAGPRNCIGMRFALLNIKVAIIGLLQNFSLRTCQETQIPLEVNSFGLLTTKKPIVLR FIPRAEIKRFLRFKSHHPRPNLDQCRIPKP 46% to CYP3A5 aa 255-301 SYFGVYSLDVITSTSLGMDVDWNKMNDTFVKEIKKISSVNLFSPLF AWKMILWNTLKDLCLKYRRHRDDQQVRTLLKDENHTQPGEKRPRLSKALPTPHLLSIVQREGGEPDTL IPSFLHQCAEDLGLHEERMANPPLCTLGPRPPPKKDSDSLRRYRVNSQPSTTKNLVTLDHTLRPDPLMTC >CYP3A.e gi|149409178|ref|XP_001512860.1| PREDICTED: similar to Cytochrome P450 [Ornithorhynchus anatinus] 53% to CYP3A4, C-term is wrong XM_001512810, NW_001594494.a 3561573-3585321 MRGERAYRPHGTGTSIELASTTFRDVFVIIIIIYGIWPFGVFTKLGIPGPRPIPFFGNILEYAQGTMHFD KKCFQKYGKIWGFYEGWKAKIAVLDLDIIKRVLVKEVFTNFTNRQNSGIEGILKHSVFAAKDKHWKKLRT LISSTFTSGKLKEMVPTIIHYGEILVKNIWYKAEKNQNVTVKDYFGAYSLDVITSTSFGVDVDSLNKMND RFVKEIRKLSSVDFFPPIFVLISVLPFITPLLKLLNINIFPNDSVEYFKRFMDNIKGTHHQGNQQQQVNF LQMMLDTQNPKEGSKAKGGVSFGKVMLSDAEILTQAFAFIFAGYESSSSVLSFIAYNLAIHPDVQQKLQE EIDTVLPNKLPLTYEALVQMEYLDMVINETLRLYSVGPRLQRVSKKTTVINGLTIPKGMTVMIPLTCLHR EPKYWLEPDEFHPE SDHFNAWHIIPLELTARGFLIPQKPIVLQFIPRAEIKKG >CYP3A.f gi|149570683|ref|XP_001520305.1| PREDICTED: similar to cytochrome P450 3A80, partial [Ornithorhynchus anatinus] 61% to CYP3A4 XM_001520255, NW_001740596 complement 2969>5783 ASPTYESIFQMDYLDMVVLETLRLFPPGGRIQRVCKETTQIKGLTIPKGTVVIIPTFVLHRDSEHWPEPE KFLPESRFSKEEKASHNPYVFLPFGAGPRNCIGMRFALLNMKAALIHLLQNFSVEPCKETPIPLELDSTG FMKPKKPIILKLVPRSGVDSED >CYP3A.g gi|149623166|ref|XP_001517912.1| PREDICTED: similar to MGC108372 protein, partial [Ornithorhynchus anatinus] 62% to CYP3A4 C-term XM_001517862 ASPTYECISQMDYLDMVVQETLRLFPPGGRIERVCKETIQIKGLTIPKGTAVIIPAFVLHRDPEHWPEPE KFLPESRFSKEEKASHNPYVFLPFGAGPRNCIGMRFALLNMKAALIHLLQNFSVEPCKETPIPLELDSTG FMKPKKPIILKLVPRSGMDSED >CYP3A.h gi|149556782|ref|XP_001519166.1| PREDICTED: hypothetical protein, partial [Ornithorhynchus anatinus] 53% to CYP3A5 XM_001519116 MSVNSAVSSQALNVLHMFPIIKHYGKLLVQNIDKKVKKNEPVNMKRIFGSYSLDVVTSTSFGVDIDSMNN PNDPFVKQITKLLSFTFLSPLFLLTVVFPFLMPVFKKMNLSLFPRDTVEFFVGVTRNFKEKRQKGVHTGR VDFLQLMVDSQSSDSNPEPSEKNHSYKEMTDTEISTQAIIFMFAGFETTSSTLNFVSYNLATHPEVQKKL QEEIDSILPNK >CYP3A.i gi|149409186|ref|XP_001512956.1| PREDICTED: similar to acyl-Coenzyme A dehydrogenase, very long chain [Ornithorhynchus anatinus] 55% to CYP3A4 XM_001512906 NW_001594494.e 3721961-3746811 MGRKRGQRAQRAPIFDGRQPILAILDPDIIKTVLVKEFHDSFPNRRNFGLNGGLDSSLTIAEYHTWKRIR TIVSPTFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIFGSYSLDVVTSTSFGVDIDSMNNPN DPFVKQINKLLSFTFLSPLLLLTVVFPFLVPVFEKMNLSLFPREFLEFFVGVTRNFKEKRQKGVHTGRVD FLQLMVDSQSSDSNPEPSEKDHSYKEMTDMEISTQAIIFIFAGFETTSSTLNFVSYNLATHPEVQKKLQE EIDSILPNK Cyan does not match GSGFWMGRLGYSERQERSPSGNRSGELTADPAGAAKSQVREGGDEGGRAAGEEEETENRVK PKVRSEGV >CYP4A gi|149577062|ref|XP_001520882.1| PREDICTED: hypothetical protein [Ornithorhynchus anatinus] 58% to CYP4A11 XM_001520832 MVSRMDGEMDKGPSAWPALLFLALALALIKGTQLFLRRQKLLKTTAQFPGPPPHWLFGHLFQVKGLSQSN SWIKYCPFGTPLWIGSFAVIFNIYHPDYLKVLLKRGDPKNKAAYRFAVPWIGHGLLILNGEKWFQHRKML TPGFHYSILRPYVKIMADSTNVMLDKWEKLTAQGETLELFQHVSLMTLDTLMKCSFSNNSSGQKDSDSKA YIQAVNNLTSMISQRIFKFYQHNNFIYWLSPLGRCFRQACKTAHQHSEQVIAERKKTLQNVFELETIQAK RHLDFLDILLCAKTKEGKGLSDEELRAEVDTFMFEGHDTTASAISWILYALALYPEHQQRCREEAQEILG ERDTVQWEDLAQLTFTTMFIKESLRLYPPVPAISRELSSPITFFDGRSLPKGSFIRIHIYSLHRNPLVWK DPEVFDPQRFTPENISQRHPYAFLPFSAGPRNCIGQQFAMNEIKVSVVQTLLRFQLEPDHSRPPEPISQL ILKSKTGIHLHLRKLP >CYP4B1 gi|149609226|ref|XP_001519517.1| PREDICTED: similar to Cytochrome P450 4B1 (CYPIVB1) (P450-isozyme 5) [Ornithorhynchus anatinus] 72% to CYP4B1 XM_001519467, NW_001773910 2638-14949 MALWKVVDLPGLSMNLSGLFPWLAGLFLTLLLLKLSKLCVRRKLFVQAFGSFPGPPAHWLFGHALEIQRG GLDKVMVWAQDYPHAFPLWLGKFIGYLNIHEPDYAKAVFSRGDPKAPDVYDFFLQWIGKGLLVLEGSKWF QHRKLLTPGFHYDILKPYIRVFVDSSKVMLDKWEKKITAGSSLEIVHDVGLMALDSLMKCTFGKGNSSQL ESENAYYLAVHDLTFLMQERIDRFQYHNDFIYWLTPHGRRFLRACKATHDHTDQVIRERKEALQNERELA VLQKKRHLDFLDILLCAKDESGEGLSDADLRAEVDTFMFEGHDTTTSGISWFLYCLALHPEHQRRCREEV QEILGNRDAFQWEDLGKMTYLTQCIKESFRLYPPVPQVYRQLNKPVQFVDGRSLPEGALVSLHIYALHRN PKVWSDPEVFDPLRFSPENSVGRHPYAFLPFSAGPRNCIGQQFAMSEMKVVSAQCLLRFEFLPDPSRPPE PIPQLVLKSKTGIHLRLRKLQ >CYP4F.a gi|149638109|ref|XP_001506150.1| PREDICTED: similar to Cytochrome P450, family 2, subfamily E, polypeptide 2 homolog [Ornithorhynchus anatinus] 77% to 4F22, cyan region does not match XM_001506100.1, NW_001794381 complement 86994-118737 MLPITDQVLKLLNLEKTSFRTYTISALLLSLLVVFFRLLLHLFQVCRQFYVTCQRLRCFPQPPRRNWLLG HLGMEKEVLMICRGRVSSELLFRLLVHGQQGHPEVLRTVLSSSSAVAPKDELFYGFLRPWLGDGLLLSRG DKWGRHRRMLTPAFHFDILKPYMKIFNQCTDIMHAKWRRLSAGAVVSLDMFEHVSLMTLDSLQKCVFSYN SDCQEKMSDYISAIIELSALVVKRQYRLHHHLDFIYYRTADGRRFQQACDIVHHFTTEVIQGRRHALNQQ GAEAWLKSKQGKTLDFIDVLLLAKDEEGKYLSDEDIRAEADTFMFEGHDTTSSGLSWILFNLARYPEYQE KCREEIQEIMKGREMDEIEWEDLTQMPFITMCIKESLRLYPPVTLISRRCTEDIKLPDGRVIPKETICLV SIYGTHHNPTVWPEPKVFNPYRFDPENPQQRSPLAYVPFSAGPRNCIGQSFAMSEMKVVVALTLLRFKLV VDRTKKVRRKPELILRTENGIWLNVEPLPARQ >CYP4F.b gi|149575306|ref|XP_001518614.1| PREDICTED: similar to cytochrome P-450LTBV, partial [Ornithorhynchus anatinus] 69% to CYP4F3 aa 217-439 XM_001518564 RPSDYIAAILELSTLVVKRHQKLHLHMDFLYNLTAEGRRFRQACRLVHDFTDDVIQKRRRTLAHQDPESW LQAKKGKTVDFIDVLLLAKVNEGPDNAGEDFPSFRSSYYFEGHDTTASGLSWVLYNLAQHQEYQEKCRAE IRELVKGRETEEIEWEDLSQMPFLTMCIKESLRLHPPVTVISRCCTEDITLLDGRVIPKGNTCMISIFGT HHNPAVWPDPEV >CYP4V gi|149537528|ref|XP_001519540.1| PREDICTED: similar to cytochrome P450, family 4, subfamily V, polypeptide 2, partial [Ornithorhynchus anatinus] 67% to CYP4V2 XM_001519490, NW_001709800 <2189>13167 EST EH000864 DAIPLCPLPASAPSGSRPPRLDPARLSGEGSERGQRDPAALWTARSPDRPPRVPMVPGHGSRPEEVAGGV AGGREGEREDSSSPGEWAFTGCLRHLRGELPGDGKGEIPAKGRLTYGTFSSVDLFQQVIQYTEEFRHMPL WKLWIGPVPMVILYHAESVEVILSSSKQISKSYVYRFLEPWLGLGLLTSTGGKWRSRRKMLTPTFHFSIL EEFVGVMNEHAQTLVEKFEKHVDRDAFDCFMDITLCALDIICETAMGRNIQVQTNGDSEYVRTIYRMSDL IQRRILMPWLWLDPCYLLFQEGREHRQKLRVLHEFTDRVIAERSKELEWSRQMALKGPGSSCARRRAFLD LLLETADDARNGLSLRDVREEVDTFMFEGHDTTAAAMSFVLYLLGSCPDAQRKVNDELDRVF >CYP5A1 gi|149560697|ref|XP_001517603.1| PREDICTED: similar to Thromboxane A synthase 1 (platelet, cytochrome P450, family 5, subfamily A) [Ornithorhynchus anatinus] 60% to CYP5A1 XM_001517553, NW_001731785 20014-50779 MALPGLLCGNLDWTAVTLGSLLLLLFVLLKWYSTSAFSQLEKLGIRHPPPTPFIGNLTLFCQGYWESHRE LIETYGPLCGYYLGRQMYIVVSEPEMIEKILVKDFGNFTNRMVSGLIPKPLSDSVVFLHGKRWSEVRWAL TPAFGPEKLNQMLPLIDRACDTLLTNLRVRAESGAALDIHRSFGCLTLDIVASLAFGLQVDSQRDPGDPF VQHCRRFFEQSVPRPVLFLLHAFPFLAPLARALPSKSRDELSDFFRRAVQDVMARRSRQPAGERRRDFLQ EMLDAHGRIGLPGPEQPDAAGPGAAPGRAPEPLTEDELVGQALVFLIAGYATAANALSFATYLLATHPEV QGKLLREVDEFGESHPPTFSSLQEGLPYLDMVIAETLRMYPPAFRFTRVAAQDCEVMGQRIPAGAVVETA VGHLHHDPAYWPEPEKFLPERFDPETGQRPPPCAYLPFGAGPRACLGTQLGLLQIKLALLRTLRAFRVAR CPGTQVPLRLTSQATLGPRDGVVVQLLPRQGPPPAPGPRQPS >CYP7A1 gi|149411112|ref|XP_001514400.1| PREDICTED: similar to cholesterol 7-alpha hydroxylase [Ornithorhynchus anatinus] 74% to CYP7A1 XM_001514350 MMTMSLIWGVLVAVCCCLWLITGIRRRHPGEPPLDNGPLPYLGCALQFGANPLKFLRAKQKKVGNIFTCK IVGKYVHFLTNPFSFHTVMRHGKHFDWKKFHFTTAAKVFGHRSIDPNDGNTTENMHQTFIKTLQGDALHS LTENMMENLQHVLKPSVPPQENPAPWVTDGLYSFCYRVMFEAGYLTLFGKELNSNKDLQKQKAQRAIYLE NFKEFDKIFPALVAGLPIHVFKSAYNAREKLAEALLHKNLQKRDKISELVTLRMFLNDTQSTFDDMEKAK THLAVLWAAQANTIPATFWSLFQTIRSPEALKAAVEEVHNVLKNAGQKVSFDGKPIVLTQAQLNDMPVLD SIIKESIRLSSASMNVRAAKEDFILHLEDGSYSIRKDDVIALYPPLVHLDPEIYPDPLTFKYNRYLDENG KTKTNFYCNGLKLKYYYLPFGSGLTKCPGRIFAIYEIKEFLILMLSYFELELVDRQPRCPPLDQSRAGLG ILPPTNDIDFRYRLKCL >CYP7B1 gi|149411182|ref|XP_001512397.1| PREDICTED: similar to oxysterol 7alpha-hydroxylase [Ornithorhynchus anatinus] 52% to CYP7B1 XM_001512347 MMSESRSHPNVNTSLFVKNCKSVQREQVFQFKFWRPKEPPLVPSWIPFLGRALQFKNDPYHFLKAQQKIH GDVFTVLFVGKYITFILDPFQFPTITRTSKHFDFKGFANHLGQKIFNYQSLYTIPNLSKDIHESFRYLQG KPLDKLVSQVMHSLQCIFKEKFSRMADWETEQMYTFCHAVIFEATFTTFYGKYPTADGHKVINEIRETFA KFDANFPKLAANIPIELLGSTKKNREFLIRQFTPELMVKRQPLAEIIQFRREFLEKYKLLQDYSKAAHHF GFLWASVGNTIPASFWALYYLLRHPEALAVVRDEIDHLLQSTGQANRPGSFIYLTREQLDNLVYLDSLIL ESFRLNSASTNFRIIQEDFTLQLEDGRDFNLRKGDWLALFPQTMHRDPEIFEDPEVFKFDRFVENGKKKT TFFKRGRKLKYFLMPFGSGVSMCPGRFFAVSEIKQFLILLLVHLEAEIIEEKNLVSNNERLGFGILYPNS DISFRYRWKASLASPRSHSRAPGLYGIFKATLGYVEGFYLWKLPRPTRSFTSAVGRPREPLPPMPLLEVP GTTLPVAGGSG >CYP8A1 gi|149639813|ref|XP_001507523.1| PREDICTED: similar to prostacyclin synthase, partial [Ornithorhynchus anatinus] 65% to CYP8A1, XM_001507473 LLLRSSHPGEPPLDRGLIPWLGHALEFGKDTAHFLSRMKQKHGDIFTVLAAGRFVTVLLDPHSYDSVVWE SSSKLDFHKYAVFLMERIFDVRLPHYDPREEKAKLKPTLLNQNLQTLTKATLLNLRTLLLPELGEGAQVW RETGLLQFSYSTLFRAGYLTLFGNEGARYDDPAGQTQDRAHSAEVYQHFRQLDHLLMKLARSSLSSGEKE EVAGIKVRLWRLLSTQRLRGKANKSCWVESYREHLEALRVGEEMQARAMLLQLWATQGNAGPAAFWLLLF LLKNPKALAAVQGELERVFGQTGQPLTPKESVTQETLDNTPIFDSVLSESLRLTAAPFITREVLDDLDLP LADGRKYRLRKGDRLLLFPFLSPQMDPEIYERPEEFKFDRFLNPDGTEKRDFYKGGKRLRNYNMPWGAGN NVCLGKSHAINSIKQFVFFLLNNFNLELKNPEEPIPKFDKSRYGFGLLQPERDVTVRYRAKSSPER >CYP8B1 gi|149538935|ref|XP_001512917.1| PREDICTED: similar to seven transmembrane helix receptor, partial [Ornithorhynchus anatinus] 48% to CYP8B1 aa 104-363 XM_001512867 RELVFHVFGYRGPSEDHSIILNASVKHLMGQGLEHMTQVMMENLAKVLPRRDGPGAAGWRHDELFHFSYS LVFRAGYLSLFGYEEETGVGPQLDSTFYKFRKYDSFFPRLAYSVLTPWEKAQVEQLKHHFWDLLEYQKME KWANKSHWLGDQQRRLTELGTPGSMLGRFNFMLLWASQGNTGPASFWALFYLLKHPEALRAVRAEVDGVL REAGWQGGGSLFQVTHSMLQRTPVLDSVLEETLRLTAGPILIRSVLQDM >CYP11B2 gi|149636551|ref|XP_001512763.1| PREDICTED: similar to cytochrome P-450 (11beta, aldo) [Ornithorhynchus anatinus] 50% to CYP11B2, 49% to CYP11B1 XM_001512713 MLEGLRRSARGGAGWAPALLRGLTTQVLQEGAVREVAGAPQVGALPFDAIPQSPGNSWIKVLKLWRGNGL ETFHYQQEKLFQQLGPIYREKLGKMTSVNVMLPEDALRLFQVEGTHPRRMTVVPWLAHRLTRRHKCGLFL LNGQDWRLSRKMLNQDIISPAGVRQYLPLLDTVAQDFSRLLQSRLQHNPRGSITVSIQQDLFCFTVEAST FALYGERLGLLGPNPQPEGLKFIKALGRMLETTLPLLYLPPVLARLLYPRIWEQHLLSWDYIFEHADKCM QNIYQELCLGRPLRYTGIMAELLIKADLSLESIKANMTELTAGSVDTTAYPLLFLLFELARNPEVQVTLR EEVLAAEEAGIGANGDLLELINALPLVRGAIKETLR GGENYNVPAGTLCNVALYPMGRSPAVFACPERFD PRRWQGKDNNFRSLNFGFGLRQCIGRRFAESEMVLFLRHILKNFQVETVSREDLKTVYHFVLMPDSHPLL TFRTLK >CYP17A1.a gi|149544763|ref|XP_001519415.1| PREDICTED: similar to steroidogenic enzyme cytochrome P450 17a-hydroxylase/17,20 lyase, partial [Ornithorhynchus anatinus] cyan does not match MPTWERRPAFGSGPTLNVQREAAFAWDLDGESNFQRLLSPARGASLQRGSPTGSLCPGNASSLGGPTGPI PSLCFPRPGRRRSGPTPAPPFTSQLNSWGVRGTLRESRARILPSPTRALPRPSKEGPPDAPQRYHYHRLP TKRGTGPSDAAPGWWGRLLTLGGHGHPFVPSIRLEARPLPGHTV 45% to CYP17A1 XM_001519365, NW_001716571 1844>10220 TTNILSQDGKDIAFSNFGPMWKQQRK LVQSAFAMFKDGSLHVEKIVNQQAAFLCKLLAERQGTSFDFSREIFLVVSNVVSHLCFNSCFELGDPELD QLLMNSEHIINTIAKDSLVDIFPWLRVFPNKELRLLKKSVEIRNKLLKKRFKDHQ >CYP17A1.b gi|149634544|ref|XP_001511766.1| PREDICTED: similar to 17-alpha-hydroxylase/17,20 lyase [Ornithorhynchus anatinus] CYP61% to CYP17A1 C-term XM_001511716 (gap in seq) DNNNSRMPQEPSMTDDHVIMTIGDIFGAGVE TTSSVLKWFIAFLLHYPQVKKKIQEEIDRKIGFSRTPALSDRNQLIYLEASIREILRIRPVTPLLIPHIA MKDSSIGEYTIHKGTRIMINIWSLHHDEMEWRNPDRFEPDRFLDKKGEQLISPSSSYLPFGTGPRVCLGE SLARIELFLFLAWILQRFDFEVPENGEKPNLEGKTGVVYQVLPFQVVVKLRKGWMGTEVRE* >CYP17A1 combined from two sequences above TTNILSQDGKDIAFSNFGPMWKQQRK LVQSAFAMFKDGSLHVEKIVNQQAAFLCKLLAERQGTSFDFSREIFLVVSNVVSHLCFNSCFELGDPELD QLLMNSEHIINTIAKDSLVDIFPWLRVFPNKELRLLKKSVEIRNKLLKKRFKDHQ (22 aa gap) DNNNSRMPQEPSMTDDHVIMTIGDIFGAGVE TTSSVLKWFIAFLLHYPQVKKKIQEEIDRKIGFSRTPALSDRNQLIYLEASIREILRIRPVTPLLIPHIA MKDSSIGEYTIHKGTRIMINIWSLHHDEMEWRNPDRFEPDRFLDKKGEQLISPSSSYLPFGTGPRVCLGE SLARIELFLFLAWILQRFDFEVPENGEKPNLEGKTGVVYQVLPFQVVVKLRKGWMGTEVRE* >CYP19 from Brandon Hale Contig15980:2526-10166 UCSC browser 76% to CYP19A1 human, N-term in a seq gap WWILTLLLLLLLLLLAGTPLALWSGRDAAAIP (1) GPGYCLGLGPLVSHGRFLWMGIGSACNYYNRMYGEFMRVWIGGEETLIISK (2) SSSMFHIMKHNHYSCRFGSKLGLQCIGMHEKGIIFNNNPTLWKAIRPFFTK (1) ALSGPGLVHMVAMCVQSTITHLDKLDEVTNELGYISVLTLMRRIMLNTSNALFLGIPMD (1) ESEMVMKIQGYFNAWQALLLKPDIFFKVSWLYKKYAKSI (2) KELQDAVETLLDEKRLRLSAAEKLEDHVDFASQLIFAQ (0) DRGDLTRENVNQCMLEMLIAAPGRE (frameshift one extra G base) SVTIFFMLLLIAKHPNVEQAIVEEIRTEI (1) GDRDIEMEDMQKLKVVESFIFESMRYQPVVDLVMRKALQDDVIDGYPVKKGTNIILNIGRMHRREFFP KPDEFTLENFAKN (0) VPYRYFQPFGFGPRSCAGKYIAMVMMKSILVTLLRRYHVQELEGGIEGVHKRNDLALHP DETGASLDMIFTPRTPGLLRQP* >CYP20.a gi|149634386|ref|XP_001506378.1| PREDICTED: similar to cytochrome P450, family 20, subfamily A, polypeptide 1 [Ornithorhynchus anatinus] 85% to CYP20 N-term XM_001506328.1 CYP20.b gi|149611985|ref|XP_001506190.1| PREDICTED: similar to MGC52842 protein, partial [Ornithorhynchus anatinus] 75% to CYP20 C-term XM_001506140 NW_001794176 complement 215115-262954 13 EXONS MLDFAIFAVTFLLLLVGAVLYLCP (0) ASRQASGIPGMTPTEEK (2) DGNLPDIVTKGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDLLKQHINPNRT (1) SDPFETMLKSLLRYQSGLGGDAGESHIRKKLYENGVSKSLQSNFAVLIK (0) LSEELLAKWLSCPESQHVPLCQHMLGYAVKSVTQVAMGSSFEDDQEVIRFRKNHDV (0) IWSEIGKGFLDGSLDKSATRKKQYE (1) EAVMDMESVLKKVIKDRRGRNFNQHVFIDSLLQGNLNDKQ (0) VLEDSMIFSLAGCVITAN (1) LCTWAIYFLTTSEDVQKKLFKEVDQVLGKGSITQEKIEQLR (2) YCRQVLSETVRTAKLTPIAAKLQDLEGKIDHHVIPRK (0) TLVLYALGVMLQDHSAWPSPYK (2) FDPDRFVDESAEKNLSVLGFSGTQECPELR (2) FAYVVATILLSVLVRKLNLHPVEGQVVETKYELVTSPKEEAWITVSKRS* >CYP21.a gi|149513488|ref|XP_001516359.1| PREDICTED: similar to 21-hydroxylase, partial [Ornithorhynchus anatinus] 56% to 21A2 aa 1-180 XM_001516309 MLPLALLLLGALAALWVWGVPLLRQSKLHLPPRVPGFLHQFRPNLPNHLLRLAQAHGPLYRIHFGNQDVV ILNSKELIQEAMIKNWLNFAGRPLTFSSKLVSLGGKDLSLGNYSPAWKDLKKLTRSALLFGMRNKMEPLV WQLTHQLCEDFRAQPGSAVDLFQEFSRLTNRIVCTLTFGE 51% to CYP21A2 aa 247-313 METQAAGVVRDLMDYMLRELREKSGVWDVTEENLHMVLLDLVIGGTETTAATLTWVVLYLLHHPE Cyan does not match RADHGAWGGEVRSAGAALARPGSSEGRAALCAAPP GREAEGSGPPRRREREGRGDVVHAGNPSLADYLKPQVPPPRADPLAGPPASCRGVRARSPSGRGWHRLPR GGGRAGRPRGLRAPAPQRALGARRPPAPGGARVSPAGWHPGPSLHALGAAAAHPPRPAR >CYP21.b gi|149464528|ref|XP_001513953.1| PREDICTED: similar to CYP21B protein, partial [Ornithorhynchus anatinus] 59% to 21A2 aa 247-366 XM_001513903 ETQAAGVVRDLMDYMLRELREKSGVWDVTEENLHMVLLDLVIGGTETTAATLTWVVLYLLHHPEIHRRLQ EELDQELGPGRVSGSDPPASPLPYKDRERLPLLNATILPLLRLRPVVALGLPHE >CYP24A1 gi|149639846|ref|XP_001509535.1| PREDICTED: similar to 25-hydroxyvitamin D3-24-hydroxylase [Ornithorhynchus anatinus] 77% to CYP24A1, XM_001509485 MGAGELGLGGSPVRLQAAYHQKFGQMFRLKLGSFESVHVGRPGPLQDLYRREGRAPLRLRIEPWKAYRHL RGEGDGLLLLEGEDWQRVRSAFQKKLMKPKEVMKLDTKINEVLGDFIQRIDELCDENGRIKDLYAELNKW SFESICLVLYEKRFGLLQKNAGDEALDFIMSIKTVMSTFGRMMVTPVELHKLLNTKVWQAHTEAWDTIFK SVKSSINNRLERYSEKPSEDFLCDIYHHNSLSKKELYATVTELQIAAVETTANSLMWILYNLSRNPHVQE TLLKEIQTVLPDKQTPNAKDLQNLPYLKACLKESMRITPSVPFTTRTLDKETTLEEYTLPKGTVVVLNTQ VLGTNEESFKDWSRFRPERWLLEKKKINPFTHLPFGMGKRMCIGRRLAELQIHLALCWIVRKYNIVATDS KPVEILHLGLLMPDRELPIALRRR >CYP26B1 gi|149633228|ref|XP_001507383.1| PREDICTED: similar to cytochrome p450 26B1 [Ornithorhynchus anatinus] XM_001507333.1 NW_001794094 168994-185123 MTFRLPGPGSSHCAVLDEWHDLGSGGTSSKGECSPSTESTGWTGGKSHRDQPGGCRAQTGQADRIRKRSA LAEDGELAPVEPERFGVSPEVSQPAWPLPCPPPPPPRRANHRAVRPPADLARRFEFFSLPQKLRVFALMQ XXXXXXXXXXXXXXXLSQYDSLNAQEPRSLAPLQEES 73% to CYP26B1 VFSKIFSHEALASYLPKIQLVIQDTLRVWGGTP EPINVYQEAQKLTFRMAVRVLLGFSIPEDDLTHLFQVYQQFVENVFSLPVDLPFSGYRRGIQAREKLQKG LEKAIREKLQNSPDKDYSDALDILIESSKEHGREMSMQELKDGTLELIFAAYATTASASTSLIMQLLKHP AVLEKVREELRAHGILHNGCLCEGSLHLGHRRSLHYLDCVIKEAQHALTPCSATSCTVTPHTASHTLRPM HCDPTPYDLTYCGPSRXXXXXXXXRDGRFHYLPFGGGVRACLGKHLAKLFLKVLAVELASTSRFELATRT FPRLTLVPVLHPVDGLSVRFCGLDSNQNEILTETEAMLGATV >CYP26C1 gi|149631901|ref|XP_001506310.1| PREDICTED: similar to cytochrome P450 [Ornithorhynchus anatinus] XM_001506260 71% to CYP26C1 NW_001794005 67848-73801 cyan may be out of frame MSPWELSGPSTALLSLGLLTLGLLVGLAGLAGLARHLWALRWSLSRDPSCPLPLPPGSMGWPFLGETLHWLLQ () GSRYHSSRRQRYGPVFKTHLLGRPVIRVSGAQHVRTILLGEHRLVRSHWPDSARILLGPHTLLGAVGEPHRQRRR () VLSQVFSRSALESYLPPIQAALRRELRGWCGAAGPVAVFAATKALTFRIAARILLGLRLEER RCAELARTFEQLVENLFSLPLDLPFSGLRK () GIRARDRLHEHMEAVIAEKLRAGPGSGPGPNDALDLIIVSAREQGREVTMQELK () ESAVELMFAAFFTTASASTSLVLLLLQHPAAVSRIRQELSAHQLGGRCSC () PCPDPPGDGASAETPAHQAEETA CRCPPDLSLDQLGRLRYLDWVVKEVLRLLPPVSGGYRTALRTFELD () GYQVPQGWSVMYSIRDTHETAAVYRSPPDGFDPERF () GPRAPEGGRGPG RFHYIPFGGGVRSCLGQELARTVLKLLAV ELVRTARWELATPAFPDMHTIPIVHPVDGLRLLFHRLPPDPAADPAAPRS >CYP27C1.a gi|149581564|ref|XP_001509012.1| PREDICTED: hypothetical protein, partial [Ornithorhynchus anatinus] 85% to CYP27C1 XM_001508962 VATILYECRLGCLEDPIPELTSEYIEALELMFSMFKTTMYAGAIPRWLRPLIPKPWREFCRSWDGLFKFS QIHVDKKLRDIQSQLDRGERVRGGLLTHLLLSKELTLEEIYANMTEMLLAGVDT >CYP27C1.b gi|149476406|ref|XP_001519194.1| PREDICTED: similar to FLJ16008 protein, partial [Ornithorhynchus anatinus] 86% to 27C1 aa 411-542 XM_001519144 LFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYATSYEDENFPLATEFRPERWLRKGSMDRVDNFGSIP FGYGIRSCIGRRIAELEFHLVMIRLLQHFEIKTSPQTKTVPAKTHGLLTPGGAINVKFVSRK >CYP39A1 gi|149633473|ref|XP_001511640.1| PREDICTED: hypothetical protein [Ornithorhynchus anatinus] 70% to CYP39A1 XM_001511590 MNSQYGPIFTVFALGNRMTFVTEEEGINTFFKSKEVSFELAVQNPVYHTASISKEIFFLNHDKLYGLMKG KMSTSNMHHFFGKLVEELHEHLEYLGTEGTQDLCNLVRNVLFPSSVNILFGKGLFPTSQRKIKEFEEQFR IYDEGFEFGSQMPECLLRNWSKSKQWFLRLFEKAISDLETSKTSGDESKTLMQNMLDILKQEIKNEHTGP SYAVLLLWASQSNAVPIAFWTLAFLLSHPSIYKNIMEDLTSVFGKAGKRKIQVSEDDLKKLPLIKWCVLE AIRLRAPGVITRKVVKPVKILNYTVPSGDILMLSPFWLHRNPKYFPEPEVFKPERWKKANLEKNAFLDCF VAFGGGKCQCPGRWFALMEIQIFVILILYKYDFTLLDPVPKQSSRHLIGTQQPEGPCRTKYEQRK >CYP46A1 gi|149636926|ref|XP_001512720.1| PREDICTED: hypothetical protein [Ornithorhynchus anatinus] 60% to CYP46 XM_001512670 MKRNLCSSRAKEYGPVVRLNAFHRISIFLTSPEAVKEFLMSPQYQKDPRVYGQLHSLFGERFLGKGIITI QEHERWHKQRKIMDPAFSRSYLVGMMGTFNEKAEQLMEILEEKADGKMEVSLLNMMNRVTLDIIAKVAFG METNTLHDDQTPFPHAVTTAMKGVSMIRNPMLKFLPGKRKVVDEIRSSIRFLRQTGKECIERRREAIQNN EEIPPDILTQILKGEATEGPRDDETMVDNFISFFIAGHETTANQLAFTILELSRHPEILEKLQAEVDEVV GSKRDIEYEDLGKLQYLSQVFKEALRLYPPGPGTSRWLDKELVVDGIRLPAHTSIFLSSYTTGRLETNFK DPLVFNPDRFSPEAPKPYFTYFPFSLGPRSCIGQNFAQMESKVVMAKFLQRLEFQLAPGQNFTILDTGSL RPKDGVFCTLTPRKSHCDFSGGIGGNMISEGL >CYP51A1 gi|149521644|ref|XP_001517490.1| PREDICTED: similar to lanosterol 14-demethylase, partial [Ornithorhynchus anatinus] XM_001517440 some parts of the translation in Genbank are wrong EST EH003064 2 aa diffs AAPN01271409.1 C-term of CYP51 85% to CYP51 KFPPHIFSPIPF LGHAVAFGRSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFG KGVAYDVPNPVFLEQKKMLKTGLNITHFKQHVPLIEKETKEYFASWGESGEKNLFEALSELIILTASHCL HGREIRSQLTEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHRAIKKIFYEAIRRRRETREPVDD ILQTLLDASYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTGTWLGFFLARDRRVQAQCFEEQKRVCGDDLP PLNFDQLKDLTVLDRCLKETLRLRPPIMTMMRMARTTQ TVNYTTMIHTPNNPVVRYRRRVAGEAGGGGRP*     +,-mn ? @ N Z [ / 0 v w   K L i j k l r   = > Q R ()opٯ" *h2B*CJOJQJaJphh2B*CJOJQJaJphh2B*phh2B*CJOJQJaJph%hy8h2B*CJOJQJaJphh2E,-n @ [ 0 w  L j k  > R edzXedzXedzX )p"Ea6}drGcedzXedzX!"8DEp`ap56p|}cdpqrFGpbcpuvwxHI{|12h2B*CJOJQJaJphh2B*phh2h2B*CJOJQJaJphScvwI|2mBFGZ<qedzXedzX2HlmABEFGHOYZ;<JpqGH  (4@A  yz" *h2B*CJOJQJaJphh2B*phh2h2B*CJOJQJaJphh2B*CJOJQJaJphLH A z#jK  edzXedzX "#ijJK_my     % & l m $!%!M!N!p!q!r!~!!!!!!!!!!!ﯯ" *h2B*CJOJQJaJph" *h2B*CJOJQJaJphh2B*phh2h2B*CJOJQJaJphh2B*CJOJQJaJphE  & m %!N!q!r!!!!!!!!@"""""S#####$$edzXedzX!!?"@"N""""""""""N#R#S#a#########$N$$$$$$%%L%M%N%%%%%%%%%7&8&D&i&j&&&&&&>'?''''''((((({(|((((((((((((.)/)0)h2B*CJOJQJaJphh2B*phh2h2B*CJOJQJaJphS$%M%%%%8&j&&&?'''((|(((((((/)0))))=***edzX0)1)7)))))))))<*=******++X+Y+++++++++,,=,K,L,c,d,e,,,,,,--@-A-{-|---------......//M/N//////"0#0i0j000000516171h2B*phh2h2B*CJOJQJaJphh2B*CJOJQJaJphS*+Y++++,L,d,e,,,-A-|----../N///#0j00061edzXedzX61711142{22 3P33333f444.5u556J66667O777$8edzXedzX7181?11111113242z2{22223 3O3P3333333333P4e4f4t44444-5.5P5t5u55566I6J6P66666666677(7N7O777777#8$8j8k888888888h2B*phh2h2CJOJQJaJh2B*CJOJQJaJphh2B*CJOJQJaJphN$8k88889999(:o:::D;;;;;;;;6<}<~<<5=|== >edzXedzX89999999':(:n:o::::::C;D;;;;;;;;;;;;;5<6<|<}<~<<<<<<=4=5={=|==== > >P>Q>>>>>>>>>???? ???????@@\@]@s@t@u@v@}@@@@Ah2B*phh2B*CJOJQJaJphh2B*CJOJQJaJphh2T >Q>>>>>????@]@t@u@@ ATAAAA!Bb?b]bkblbmb|bbbbbcc;ccHc]cccccccc ddTdUd]ddddddddee!e"e]eheieeeeeeh2B*CJOJQJaJph" *h2B*CJOJQJaJphh2B*phh2h2B*CJOJQJaJphLUdddde"eieeeef[ffffg'g_gggh.hfhhhhi3i4iedzXedzXeeffZf[f]ffffffffgg&g'g^g_ggggghh'h-h.hIhdhehfhhhhhhhii2i3i4i5i6666666666666666666666666666666666666666666666666hH66666666666666666666666666666666666666666666666666666666666666666p62&6FVfv2(&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv&6FVfv8XV~ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@ 0@66666_HmH nH sH tH H`H Normal CJOJQJ_HaJmH sH tH L`L  Heading 1$@&5B* CJ\aJphDA D Default Paragraph FontRiR 0 Table Normal4 l4a (k ( 0No List R/R Heading 1 CharCJ OJPJQJ^JaJ ph/TD/D msonormaldd[$\$OJQJHB`H 0 Body TextB*CJOJQJaJphH/!H 0Body Text CharCJOJPJQJaJ4@24 y80Header  H$B/AB y80 Header CharCJOJPJQJaJ4 @R4 y80Footer  H$B/aB y80 Footer CharCJOJPJQJaJPK![Content_Types].xmlN0EH-J@%ǎǢ|ș$زULTB l,3;rØJB+$G]7O٭Vj\{cp/IDg6wZ0s=Dĵw %;r,qlEآyDQ"Q,=c8B,!gxMD&铁M./SAe^QשF½|SˌDإbj|E7C<bʼNpr8fnߧFrI.{1fVԅ$21(t}kJV1/ ÚQL×07#]fVIhcMZ6/Hߏ bW`Gv Ts'BCt!LQ#JxݴyJ] C:= ċ(tRQ;^e1/-/A_Y)^6(p[_&N}njzb\->;nVb*.7p]M|MMM# ud9c47=iV7̪~㦓ødfÕ 5j z'^9J{rJЃ3Ax| FU9…i3Q/B)LʾRPx)04N O'> agYeHj*kblC=hPW!alfpX OAXl:XVZbr Zy4Sw3?WӊhPxzSq]y yX 2!0)718AG)ODW_ekqx ADFHJLOQSUWY\^`bdg c $*61$8 >CJPWT^Ud4ientyBCEGIKMNPRTVXZ[]_acefh@ @H 0(  0(  b S  ?C"zX2y8oyqy@y@UnknownG.[x Times New Roman5^Symbol3. *Cx Arial7Courier?Z PTimesTimesC.,*{$ Calibri Light7.*{$ CalibriA$BCambria Math"1hdgdgPg>Pg>%01y1yB@P $P'y82!xx4$ Normal>gi|149524993|ref|XP_001516537David R. NelsonMooney, Charles P Oh+'0  (4 T ` lx' >gi|149524993|ref|XP_001516537David R. NelsonNormalMooney, Charles P2Microsoft Office Word@F#@ G@ GPg ՜.+,0 hp  'University of Tennessee>1y >gi|149524993|ref|XP_001516537 Title  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghiklmnopqrstuvwxyz|}~Root Entry FaG1Tablej= WordDocument2SummaryInformation({DocumentSummaryInformation8CompObjr  F Microsoft Word 97-2003 Document MSWordDocWord.Document.89q