ࡱ>   YbjbjҬҬ 2Ɯ_Ɯ_?  8_"!!!!!!!$S% (z""T"!!!J!!!!!!`YELJ!!/"0_"!(!(!!(! !""!_"( X `:  Ixodes scapularis JCVI PROTEINS 0.5 (first in list, 133 entries) Ixodes scapularis VB PROTEINS 0.5 From Fungal P450 Database (second in list, 195 entries) Wikel strain joint effort by the Broad Institute and the J. Craig Venter Institute (JCVI) Assembly was performed at JCVI and consists of 369,492 scaffolds built from 570,637 contigs with an estimated 3.8x coverage of the assembly. From the combined JCVI and VectorBase sets of sequences. There are 331 sequence pieces, 223 different non-overlapping sequences. Blocks of yellow sequences are adjacent on the same contigs D. Nelson Nov. 2, 2009 CYP2 clan (99 sequence pieces, 63 different non-overlapping sequences, some will join) >&P450_Is127, VBpre_P001765 77% to P450_Is307 MSFLSEKVLFFWDWRWLTTALVFLLSYLVVRFDHKVSKYPKGPFPLPVVGNLLELRNTKELYKAANNWSQKFGDPITLWM GEKPMVVLNTHKLVKEAFIERRHEFAGRFSTKMAELQRQGNHNIMFEDYNSTWKTLRKLALTAVR >EW883500 EST G894P549RJ1 3 aa diffs to P450_Is127 & = frameshift MSFLSEKALFFWDWRWLTTALVFL LSYLVVRFYHKVSKYPKGPFPLPVVGNLLELRNTKELYKAANNWSQKFGDPITLWMGEKP MVVLNTHKLVKEAFIERRHEFAGRFSTKMAELQRQGNHNIMFEDYNPTWKTLRKLALTAVR KYAVSDSLENLCCEVVDAYVDSLK & EGPNIVDSRAPFMYMLYNIIGMSVYGAKFDKESP >&P450_Is154, VBpre_P002090 82% to P450_Is307 WLTTALVFLLSYVVVRFYRKVSKYPKGPLPFPVVGNLLALRNTNQLYKMAENWARQYGDPITFWMGEKPMVVLNTQKVVK EAFVEKRHEFAGRFSTKMAELQRQGNNNIVMEDYNPTWKALRKVALTAVRKYAVSDSLENLCCEVVDAYVDSLKEGSNVV DSKAPFLYMLYNIIGMSVYGAKFDKESPELA >EW835101 EST 4 aa diffs to P450_Is307 (first seq) MSFLSEKALLLWDWRWLTTALVFLFSYVAV RFYYKVSKYPKGPFPLPVVGNLLGLRNTSELYKATVEWSTKYGDPITLWMGERPMVILNT QKLVKEAFVERRHEFAGRFPSKMGDLQTQGNHNIIMEDYTPTWKALRKVALTAVRKYAVS ESLETLCCEVVDAYVDSLKEGPNVVDSKVPFEYTLYNIIGMSVYGAKFDKESPELTKLQA INR >EW958639 EST 1 aa diffs and two frameshifts to P450_Is307 (first sequence) MSFLSEKALLLWDWRWLTTALVFLFSYVAVRFYYKVSKYPKGPIPLPVVGNLLGLRNTSELYKATVEWSTKYGDPITLWM GERPMVIINTQKLVKEAFVERRHEFAGRFPSKMGDLQTQGNHNIIMEDYTPTWKALRKVALTAVRKYAVSESLETLCCEV VDAYVDSLKEGPNVVDSKVPFEYMLY & XIIGMSVYGAKFDKESPELTKLQXXX & REFLRIAPNGLPSDIVPWLGLLYRNRER >EW951039 EST 1 aa diff to P450_Is307 (first seq) MSFLSEKALLLWDWRWLTTALVFLFSYVAVRFYYKVSKYPKGPIPLPVVGNLLG LRNTSELYKATVEWSTKYGDPITLWMGERPMVIINTQKLVKEAFVERRHEFAGRFPSKMG DLQTQGNHNIIMEDYTPTWKALRKVALTAVRKYAVSESLETLCCEVVDAYVDSLKEGPNV VDSKVPFEYMLYNIIGMSVYGAKFDKESPELTKLQAINREFLRIAPNGLPSDIVPWLGLL YRNRERKVELLFKEFLEIVDTLYKRAAKSY >&P450_Is132, VBpre_P002091 Same as P450_Is307 (first sequence) GTGTSMAQLQWLSLIMTRKPEIRERMMTEIETNLGQDRPRLQDREKLPYTQACIMESLRRFPNVPLGLPHNTTCDTEVGG KFVPKDTGILYNIYAI >&P450_Is177, VBpre_P013577 Same as P450_Is307 (second sequence) MTPEPHVGEHSSGRIVRNISPRPLFYKAVDRIRRQ SVIGQKESLEFRCAAYALKQFVAGTGDQTNIMSFMSEKVLLFWDW RWVTTAVVFLLSYVVVRFYHKVFKYPKGPFPLPIVGNLL TLRNINELYEATEAWARKYGDPITLWMGEKPMVVLNTQTLV KEAFIERRHDFAGRLPTKMGELQTLGNHDIIFEDYNPRWKALRNVALTAVR KYAVSESLDTLCCQVVDAYVDSLKEGPNV VDSKVPFEYMLYNIIGMSVYGAKFDGESPELAELQAINREFFKVAPNGLPSDIVPWLGLLYRARERKIELLFKKGWKILD DLYKRASKSYVPG QDRPKLQDREKLPYTQACILESLRMYPNAPLGIPHSTSCDTEV GGKFVPKDTGILYNIYAINHDPNL WDDPEAFRPERFLDPVTGKVKQELLPQLMTFGLGPRTCPGEKLAHVDMFYVLVRFMQRVEISAPEGKANTAIAPL GSSLF LIPGEQDVVLTRKD >&P450_Is133, VBpre_P002092 Same as P450_Is307 (third sequence) FENEGPELARIRRINESVTELAPNGLPSDIVPWLGILLRNREKKIESLYTEFFELIEALYKKAVHCHVPGSIQNFTHSML AAREEALLQKKCDSQYLTEANMVQILLDVFGASTDTTIGELRWLCLTMTRKPEIQAKIQREIQDYL >&P450_Is134, VBpre_P002093 Same as P450_Is307 (fourth sequence) LVFLLSFHLVRFYRKVSKYPKGPFPLPLVGNLLSLRGETPLHLKAEQWHRRYGDPFTMWMGEKPMVMLNSYQVLREAFVD KRHEFAGRFPTKIVALIIKQNTPVNEEAALNISRQTPPTLQDKEKLPFTVACLYETLRFYPILPMGFPHNTACDTHA >P450_Is307, 35669.m000078 at least 4 genes MSFLSEKALLLWDWRWLTTALVFLFSYVAVRFYYKVSKYPKGPIPLPVVGNLLGLRNTSELYKATVEWSMKYGDPITLWM GERPMVIINTQKLVKEAFVERRHEFAGRFPSKMGDLQTQGNHNIIMEDYTPTWKALRKVALTAVRKYAVSESLETLCCEV VDAYVDSLKEGPNVVDSKVPFEYMLYNIIGMSVYGAKFDKESPELTKLQAINREFLRIAPNGLPSDIVPWLGLLYRNRER KVELLFKEFLEIVDTLYKRAAKSYVPGKIDNFTHSMLAARDEAIEQAKNDAEHLTEANMVQIIIDIFGA GTGTSMAQLQW LSLIMTRKPEIRERMMTEIETNLGQDRPRLQDREKLPYTQACIMESLRRFPNVPLGLPHNTTCDTEVGGKFVPKDTGILY NIYAI NHDPNLWDDPEVFRPERFLDPVTGKIKQELLPQLMTFGLGPRTCPGEKLAHVDMFYVFVRFMQRVDISAPEGKAD AAIKPSVIGQKESLEFRCAAYALKQFVAGTGDQTNI MSFMSEKVLLFWDWRWVTTAVVFLLSYVVVRFYHKVFKYPKGPF PLPIVGNLLSEYLNPQFNAKLILTEI KYAVSESLDTLCCQVVDAYVDSLKEGPNVVDSKVPFEYMLYNIIGMSVYGAKFD GESPELAELQAINREFFKVAPNGLPSDIVPWLGLLYRARERKIELLFKKGWKILDDLYKRASKSYVPG GKFVPKDTGILY NIYAINHDPNLWDDPEAFRPERFLDPVTGKVKQELLPQLMTFGLGPRTCPGEKLAHVDMFYVLVRFMQRVEISAPEGK ANTAIAPL VVDAYVDSLEKGPNTVDSKDPFQFIILNIVGTYVFATR FENEGPELARIRRINESVTELAPNGLPSDIVPWLGI LLRNREKKIESLYTEFFELIEALYKKAVHCHVPGSIQNFTHSMLAAREEALLQKKCDSQYLTEANMVQILLDVFGASTDT TIGELRWLCLTMTRKPEIQAKIQREIQDYL GQTPPTLQARDKLPYTVACIYDLLTVNDQLPYVWPHLTHLRGKFIPKNTG LLYNIHAVNHDPALWTDPEVFRPERFLEPRTGKLKLEGQPPLLTFGLGPRTCPGEKLAHLKMFYVLVRLMQRVTFG LRGE TPLHLKAEQWHRRYGDPFTMWMGEKPMVMLNSYQVLREAFVDKRHEFAGRFPTKI GALQTRSNHGILFEDYNPSFKALKK VTLTAVRFDKESPEVVRLRQITDRFSEVAPNGLPSDIMPWLGILYRKTEKTIECLFSEFIELIEVLYERAVDSYIPGKFD KESPEVVRLRQITDRFSEVAPNGLPSDIMPWLGILYRKTEKTIECLFSEFIELIEVLYERAVDSYIPGKRQVIPKNTGIL YNIHAVNHDPSLWKDPEVFRPERFLDHATGKLNLEGQPPLLTFGLGPRTCPGEKLGHVKMFYVLVRLMQRLSCLRNETKL YKKAQEWSRQYGDPFTLWMGEKPTVILNSYQVLREAFVDKRHEFAGRFPIKLGALQTQGNHDILFEDYNPTWKALRKVAL TAVRKYAISESLETLCTEVVDAYVDSLEKGPNTVDSKYPFMFILFNIVGTSVFGTKYGTIH >&P450_Is308, 35669.m000079 MLAAREEALQQEKSDAQYLTEANMVQILIDIFGGATESSIGTMRWLCLTLAQRTDIQTKIQQEIEDNIGSSPPTLKDRER LPYTVACIYETLRVYPVGPLGFPHNTCCDTQAGGKFIPKDTGVLYNIHAVNHDPALWKDPEVFRPERFLDPVTGKLNLEG QPQLLSFGLGPRTCPGEKLGQMDMFYVLVRLLQRVSFGVPDGASCTDIKQLASSVFLMPAVQETVLTRMY >&P450_Is309, 35669.m000080 MNLLSEKAFFWDWRWLTTGLVFLLSYHVVRFYRKVSKYPEGPFPLPLVGNILSLRSETQLFKKVGEWSRKHGDPFTLWMG EKPMVMLSSYPVIKEAFIDKRHDFSGRIQLKLAALRLRGNHGIVFEDYNATWKALRKFALIAVRKYAMNESLETLCTGVV DAYVESLKKGDNTVDCKESFMFIIFNIIGTSVFGTKYD VVAWSLLFDFFNQMGML SMLVAREEAIGQEKGDAQYLTEGNM IQVLFDIFAGGTETTIGTLQWLCLKMTREPEIQLKIQKEIEDNLGEAPPTMKDRDKLPYTVACIYETLRFYPVAPVGLPH KTSCDTEAGGRFIPKDTALLFNVYGANHDPALWEDPDAFKPERFLDPSTGKLNLEGLPPILTFGLGPRTCPGEKLAHMDI FYVLVRLMQRVSCSVPAATMNKDIKKMDSNLFLVPAAQDIIFTRRD >P450_Is136, VBpre_P002095 Same as P450_Is309, 31% to CYP2B6 human CYP2 clan member WRWLTTGLVFLLSYHVVRFYRKVSKYPEGPFPLPLVGNILSDETQLFKKVGEWSRKHGDPFTLWMGEKPMVMLSSYPVIK EAFIDKRHDFSGRIQLKLAALRLRGNHGIVFEDYNATWKALRKFALIAVRKYAMNESLETLCTGVVDAYVESLKKGDNTV DCKESFMFIIFNIIGTSVFGTKYD KEGPELARLKEINEAFSEEAPNGLPSDVVPWLGILYRKREKKIERLFAEFIDILEG LYTRALESYVPGTIQNFAQ SMLVAREEAIGQEKGDAQYLTEGNMIQVLFDIFAGGTETTIGTLQWLCLKMTREPEIQLKI QKEIEDNLGEAPPTMKDRDKLPYTVACIYETLRFYPVAPVGLPHKTSCDTEAGGRFIPKDTALLFNVYGANHDPALWEDP DAFKPERFLDPSTGKLNLEGLPPILTFGLGPRTCPGEKLAHMDIFYVLVRLMQRVSCSVPAATMNKDIKKMDSNLFLVPA AQDIIFTRRD >P450_Is135, VBpre_P002094 Same as P450_Is308 TTGNFTHS MLAAREEALQQEKSDAQYLTEANMVQILIDIFGGATESSIGTMRWLCLTLAQRTDIQTKIQQEIEDNIGSSP PTLKDRERLPYTVACIYETLRVYPVGPLGFPHNTCCDTQAGGKFIPKDTGVLYNIHAVNHDPALWKDPEVFRPERFLDPV TGKLNLEGQPQLLSFGLGPRTCPGEKLGQMDMFYVLVRLLQRVSFGVPDGASCTDIKQLASSVFLMPAVQETVLTRMY >&P450_Is296, 35231.m000073 MQDRGKLPYTVACLLETLRMYPIVPLGLPHNTTCNTEVGGQFIPMDTGIFYNIYAMNRDPQLWAEPEVFRPERFLDPVTG KVNQELLPQLMSFGLGPRTCPGEKLAHVDMFYVLVRFMQRVSCSAPAGKSGSAIAAVNSNLFLCPAEQDIVLTRVY >P450_Is129, VBpre_P001770 Same as P450_Is296 MTRKPEIQERIKEEIERNLGQARPG MQDRGKLPYTVACLLETLRMYPIVPLGLPHNTTCNTEVGGQFIPMDTGIFYNIYA MNRDPQLWAEPEVFRPERFLDPVTGKVNQELLPQLMSFGLGPRTCPGEKLAHVDMFYVLVRFMQRVSCSAPAGKSGSAIA AVNSNLFLCPAEQDIVLTRVY >&P450_Is128, VBpre_P001769 94% to P450_Is296 VRGSIFISQPSETGQVRPG MQDRGKLPYTVACLLETLRMYPIVPLGLPHNTTCNTEVGGQFIPKDTGIFYNIYTMNRDPQ LWPEPEVFRPERFLDPVTGKVNQELLPQLMSFGLGPRTCPGEKLAHVDMFYVLVRFMQRVSCSAPAGKSDTPIAAINSNL FLTPAEQDIVLTRVY >&P450_Is227, 34558.m000012 31% to CYP2J2 human VKIGTANVVILSDVDHIKKFYSSKSGVVRPSNAILEELRPSTKIVP GISNLNGEAWTQNRTFILRVFGDLGFGEPSMEDH IMEELQELVSRISNTTGCLINIKDYITASVSNIIAAVMFGSRFKTGDAEHDYLVKLVRSVLDGSESGLMVDKKPNWLSRV ATSLQTKAQVNQKSRLMMQDFVKEQITEHK NTLNPDFNRDFIDGYLKKIKESDYKSASHFNENNLLGNAAEFLLTGTGPS STRIFWFLHICAQNPNSVQNRIQREIDDVVGPHRQPTWEDRKKMPFTMASLKEGLRWKTIGPIGGSRGTLKDTFIGEYLI PKGTIVLLNLRAVHRNPAYWDNPDEFDATRFMTSDGKLLEKNEDYFIPFGVGRRNCPGQVLGNAQMFLYTTTLLQKFNIF PEYQDQLESIGSPDLATADPRVQKLRFVPR >P450_Is058, VBpre_P003813 Same as P450_Is227 GISNLNGEAWTQNRTFILRVFGDLGFGEPSMEDHIMEELQELVSRISNTTGCLINIKDYITASVSNIIAAVMFGSRFKTG DAEHDYLVKLVRSVLDGSESGLMVDKKPNWLSRVATSLQTKAQVNQKSRLMMQDFVKEQITEHKNTLNPDFNRDFIDGYL KKIKESDYKSASHFNENNLLGNAAEFLLTGTGPSSTRIFWFLHICAQNPNSVQNRIQREIDDVVGPHRQPTWEDRKKMPF TMASLKEGLRWKTIGPIGGSRGTLKDTFIGEYLIPKGTIVLLNLRAVHRNPAYWDNPDEFDATRFMTSDGKLLEKNEDYF IPFGVGKRNCPGQVLGNAQMFLYTTTLLQKFNIFPEYQDQLESIGSPDLATADPRVQKLRFVPR >&P450_Is139, VBpre_P013148 66% to P450_Is227 MDDKFTLKKKAQNIGTSKFNGKAWKQNRNFLLTVFEDLGFGKPSIEDHIMEELQELISQLSNTAGCLINVKDYITASVSN IIAAVMFGSRFETGETTHKCLVKHLKNILDGGEFGLPVETKPKWLSRVMASLRLNKPEGKRESWLAIRELVREKITEHKN TLNPDWNRDFIDGYLQKMREHHADPTSPFSEENLQEHTAEFLLSGTGPLSMRISWVLHICAHNPNSVQFKIQKEIDDVVG RHRPPTWEDRKEMPFTLAALKEALRWISVGTIGCSR >&P450_Is089, VBpre_P010580 66% to P450_Is227 GTSKFNGKAWKQNRKFLLSVFEDLGFGKPSIEDHIMAELQELVCQLSNTAGCLINVKDYITASVSNIIAAVMFGSRFDAG ETKHKCLVKHLKNILDGSEFGLTVETKPKWLSKVMSSLPLNKPEVKRESWLAIRELVREKITEHKNTLNPDFNRDFIDGY LQKMREHHADPSSPFSEENLQEHTAEFLLSGTGPLSMRIFWVLHICAQNPNSVQSKIQKEIDDVVGRHRPPTWEDRKEMP FTLASLKEALRWISVGTIGCSRSVPEDTVIGDYFIPRGSIALINVRAVLRNPAYWSNPDDFDPTRFLTNDGDKLVKKGDA FIPFGVGKRSCPSQSLAIVEMFLYIATLLQKFNVFPEYGDQLVNIGSANATADTFVQRLRFVLR >&P450_Is017, VBpre_P009003 85% to P450_Is227 QNTLNPDFNRDFIDGYIKKIKESDSESASHFNENNLLGSTAEFLLTGTGPPSSQIFWFLPICAQNPNSVQNKIQKEIDDI VGPHRQPTWKDRKSMPFTMASLKEGLRWKTIGIISGSRGILKDTFIGEYFIPKGTIVFLNLRAVHKNPAYWNNPDEFDPT RFMTSDGKLLEKNEDCFVPFGVGKRNCPGQVLGNAQLFLYTTTLLQKLNVFPEYQDQLDIIGSVDLAEIDPRVQRLRFVP R >&P450_Is266, 27977.m000023 MGNDVLCDWKNFIREAAADELASRPPLGGVSEVVQVDESLFRASGSTTVDGFWRGNNVPGCSSDHYRGTKDKGPWIVGLI WESSGELHLFEVKKRDRRTLHTIKVKNVHPGTTVILNKWKGHNGLWTVHNELGHMVLNHLTVNRSENFVDPETGAHTQMI KSAWTALKQDFLKRGKGTSNTLHPSHLTWYWWNSINGRTMYRGPFLRLLEVIGQRWLLNRAAEFVADPSVADVAPDMYDV RALESLLCDTPSALQQRLEYAIMKSMQICTQHCQAVLEGLGKKNSHLASSQIAAATR GIVNSAGALWREQRAFLHRVFRD FVPRHGRPGSVALEQKMQVHIGEFLASVDSFEGSSSQVRHSIARAVSSILGSFLMSVTYSSRDSKFEQLLALFEEGFRLL TLAVPVNFIPALRYVPGSNWAYRRIKRNRRKTADYFRRIADAHRLSYVEGTVRDIVDAYLVQLAHDKARGPPDRDGSSYF SEEQLVQVLMDIFSAGLETVTSTL D DVELAGYHIPADTHVISNLWAIHMDTELWHEPELFNPGRFLVNGRVHKPDFFMPF SVGRRMCLGNHLTQTEVFLFLSNLVQRYSLELPPGENLPSMDGHVAVSHTPTPFKLKVTPRAPLCKAVA >P450_Is160, VBpre_P007817 Same as P450_Is266 RSSSRCPPGPRGLPLVGFLPFLGKDFHRTLQTLAAVYGPVYQIFLGSKRVVVISDHKLVRRAFSQAAFSGRPDTELTKLL QGY GIVNSAGALWREQRAFLHRVFRDFVPRHGRPGSVALEQKMQVHIGEFLASVDSFEGSSSQVRHSIARAVSSILGSFL MSVTYSSRDSKFEQLLALFEEGFRLLTLAVPVNFIPALRYVPGSNWAYRRIKRNRRKTADYFRRIADAHRLSYVEGTVRD IVDAYLVQLAHDKARGPPDRDGSSYFSEEQLVQVLMDIFSAGLETVTSTL EWAILFLVRHPDVQERLLFPGKLSRTREPKSLQKKLIHSTFREPMVRPFFRKHMLLKESQDHPLPRS DVELAGYHIPADTHVISNLWAIHMDTELWHEPELFNPGRFLVNGR VHKPDFFMPFSVGRRMCLGNHLTQTEVFLFLSNLVQRYSLELPPGENLPSMDGHVAVSHTPTPFKLKVTPRAPLCKAVA >&P450_Is320, 34890.m000109 VRMGSTDVLVLHDVQSIKEGLNKDEVLARPPYFLLRRMGMDGVITMNGQPWLDNRRFCLHVLRDLGFGRKSMEQHIKEEV AQLCDVLQSWDGQPKAITDIITSSISNNITALVFGERFHYDDPRRHFLDTRLVQFALNASFVSTLDFLPILRKLVSYVPS SKIRIAQEQLKDVHDFISEQMRERSNALNANVNKDLMSAYWNKINENNGGNASFNP QTLTGNALNFFGA GTHSVRASMLW HLLNCARDPEGVQRKLQQEVDEVVGRVRAPEWEDRKNMPYTMAVIWEMLRWRTVAPLGIIREAERDTTIGGFHVPAGTVV MSNVWALHHDPDVWEHPMDFDPTRFLSTDQTKLLPKPAALLPFSTGRRMCPGETLSMMELFIYLATLMQRFTVLPKEGDT ISMDIFDGFITLPLHTQEIRFVPR >P450_Is021, VBpre_P000673 Same as P450_Is320 MDIILALVAILILSVLLFKNKSKATDKNKILAPGPKGLPILGYMPFIGPTPHVKYKELSKTYGPIVR VRMGSTDVLVLHD VQSIKEGLNKDEVLARPPYFLLRRMGMDGVITMNGQPWLDNRRFCLHVLRDLGFGRKSMEQHIKEEVAQLCDVLQSWDGQ PKAITDIITSSISNNITALVFGERFHYDDPRRHFLDTRLVQFALNASFVSTLDFLPILRKLVSYVPSSKIRIAQEQLKDV HDFIRQQMRERSNALNANVNKDLMSAYWNKINENNGGNASFNP LSYFDHETYFCSTWADYMSS GTHSVRASMLWHLLNCA RDPEGVQRKLQQEVDEVVGRVRAPEWEDRKNMPYTMAVIWEMLRWRTVAPLGIIREAERDTTIGGFHVPAGTVVMSNVWA LHHDPDVWEHPMDFDPTRFLSTDQTKLLPKPAALLPFSTGRRMCPGETLSMMELFIYLATLMQRFTVLPKEGDTISMDIF DGFITLPLHTQEIRFVPR >&P450_Is328, 33939.m000014 35% to CYP392C1 MESEALAPGGIAWEWA SFVPLFAITAAIIWYIYQSQDNSKLPPGPKGVPLLGYIPFLGKNHHLKFAELAKVYGPIVRFKY GMVNVVVLNDYASVKKWLTHTAFHSRLRNVFCTNTGLLG-----IGTLNGEAWRTNRRLCLGILRDNGWKQAVMEEQTKEELQYF CGKLSQYREKPVPIKQLAMTSIANGIMKILMSVSYPFGDPRRVLLDRHMSQVGRAISSCSLIVWAPLWLYSLVGRLPYTS LHSMRSGFQGIVAFIKERVREHQELLDENSSLDFTDAFLKETCEYRKGPDSHISVKYAAGHVLALLSAGTNPVSSSIVWH LLNCADKPGLQNKIREEIDRVIGQQRMPAWGDRYNMPFTMACIWETYRWRTMNPIGIPRGCEEDVSID NYVIPKGTIVLP NLWAVHMDPTLWKDPEAFDPSRFLTADGSGLIAKPEHLVPFSVGKRMCPGEAASNMQIFLYLTGILQKFIVMPEDGVPVD LSVDCVTFNSPMMQNLRFIPRS >P450_Is165, VBpre_P002963 Same as P450_Is328 SFVPLFAITAAIIWYIYQSQDNSKLPPGPKGVPLLGYIPFLGKNHHLKFAELAKVYGPIVRFKYGMVNVVVLNDYASVKK WLTHTAFHSRLRNVFCTNTGLLGTTFAGIGTLNGEAWRTNRRLCLGILRDNGWKQAVMEEQTKEELQYFCGKLSQYREKP VPIKQLAMTSIANGIMKILMSVSYPFGDPRRVLLDRHMSQVGRAISSCSLIVWAPLWLYSLVGRLPYTSLHSMRSGFQGI VAFIKERVREHQELLDENSSLDFTDAFLKETCEYRKGPDSHISVKYAAGHVLALLSAGTNPVSSSIVWHLLNCADKPGLQ NKIREEIDRVIGQQRMPAWGDRYNMPFTMACIWETYRWRTMNPIGIPRGCEEDVSID >&P450_Is164, VBpre_P002959 91% to P450_Is328 LQNKIWEEIDRVIGQQRMPAWGDRYNMPFTMACIWETYRWRTLSPIGIPRNCEEDVSIDNYVIPKGTIVLPNLWAVHMNP KLWKDPEAFDPSRFLNADGSGLIAKPEHLVPFSVGKRMCPAEAASNIQIFLYLTGILQKFIVMPEDGVAVDLSVDCVVFN IPKTQNLRFIPRS >&P450_Is176, VBpre_P013575 70% to P450_Is328 VKYGMVNVVVLNDYASVKKWLSHSAFQSRLRNVFCRNTGVLGIATLNGEAWRENRRVCLNILRDNGWKLANMEEQIQEEL QYLCSKLTKHNGIPVHINQHLKASIEKCIMKMLIGEYYRIGDPRRRLLDKCMSQVGRGLSSCSLVVWAPSWLYTIAGYLP FSSVHMLRSGYRGVVEFVSEKIREHQEVLDEHTILDFTDAYLKETCEYRKDSNPHISVKYAAGHVVGLMGAGVDPVSNSI VWHLLNCADKPSLQNRIRQEVDGVIGQRRAPTWQDRYSMPFTMACIWETHRWRTMSPIGIPRG >&P450_Is185, VBpre_P011203 54% to P450_Is328 VQSRIHAEIDRTVGRNRQPAWKDRFEMPFTTASMWEILRWRTEGSLGMPRGVKEDIILGGFIIPKGTVVLPNSRGIKRSP ELWKRPDDFDPTRFLTPDGAALIKKPEYHLPFSVGKQTISLRSILRLVWRYMHLINGHTFRQMT >&P450_Is218, 23011.m000014 38% to CYP392A20 mite MEWLSVLYLAVASVLAAYLLAILPRKRTLPRGAKLAPGPSGLPILGHLPFIARSIHEVKCRDWAKTYGPIVRINMCYLDV VVLNDLESIRDYFCKQEVLNRPSNWLFKLSGIQ GLGLLNGHQWRDNRRFSMHVMRDLGYGKTHMEQHVMEESQYLADKIA EAKGEPVVLEKYLNPSASNIMSALLFGARYPYEDPRRTLLDNNMARIVSILSSGSVVAFPPAWFHKVAGMVPFLVNGVVR SITQNLVDFVRREIKQHLDTLEEHTNRDFIDGYLKKITKHKHEPETNYTTDFLVGNIMSFFIAGSNTVAVSIQWHLLNFA KNPDTLQARVHREIDEVIGRERRPAWDDRHLMPFTIATIWEMYRWRTNSPFGLPRGAEEDTYFGEYFVPKGTVVLSNLWA VHMDPDVWKNPEEFNPSRFFTEDGSRLAPKPDHLIPFALGKRMCPGETLSTMEIFLFLTTILQRYRVDAEEGREVELACD GAMSHPIPGQRLRFIAR >P450_Is010, VBpre_P003539 same as P450_Is218, 34% to CYP2U1 human FVDNHA GLGLLNGHQWRDNRRFSMHVMRDLGYGKTHMEQHVMEESQYLADKIAEAKGEPVVLEKYLNPSASNIMSALLFG ARYPYEDPRRTLLDNNMARIVSILSSGSVVAFPPAWFHKVAGMVPFLVNGVVRSITQNLVDFVRREIKQHLDTLEEHTNR DFIDGYLKKITKHKHEPETNYTTDFLVGNIMSFFIAGSNTVAVSIQWHLLNFAKNPDTLQARVHREIDEVIGRERRPAWD DRHLMPFTIATIWEMYRWRTNSPFGLPRGAEEDTYFGEYFVPKGTVVLSNLWAVHMDPDVWKNPEEFNPSRFFTEDGSRL APKPDHLIPFALGKRMCPGETLSTMEIFLFLTTILQRYRVDAEEGREVELACDGAMSHPIPGQRLRFIAR >&P450_Is271, 34517.m000009 41% to CYP392A12, 46% to CYP5147A2 Phanerochaete chrysosporium AYVPGNIQTFLGAGTNAIQRSLAWILVTCADKPSTVQAKIQQEIDRVVGQERQPIWEDRYQMPFTMATIWEMQRWRPILP LTLPRATDKDMELGGYVIPKGTIMLANIWAVNMNADLWDDPEKFRPERFIEQGGSKLRPKLDYFIPFSVG >P450_Is078, VBpre_P009077 Same as P450_Is271 MDTFCFFFTGAILILIAYIAWLRFGDFKRPKLSPGPAGCPILGYLPFLGRNHHAMFRDLARTYGPVVRISIGTVSIVAIN DYQLIKSAFTNSAVQSRIRSLFLELTGFPGVGTLNGQAWRENRQLSMNILRNLGFGKTTLEEVIKDEVSRLTERLAAMNG KPIIARMEIVTSTSNVFTSLFFGTRHPHDHPTRAALNKLLLLADRVVCTGSLVVFLPNWMFEIAGLMPFTRIYCFKKAFG GLLGFIRKQVQKHEKMELSDRNQDYIDCYLEHAQQRLENPGSHIQS AYVPGNIQTFLGAGTNAIQRSLAWILVTCADKPS TVQAKIQQEIDRVVGQERQPIWEDRYQMPFTMATIWEMQRWRPILPLTLPRATDKDMELGGYVIPKGTIMLANIWAVNMN ADLWDDPEKFRPERFIEQGGSKLRPKLDYFIPFSVG KRMCPGEALAPVEIFLFTTGILQKFTVLPEDGKTIDLTVDSGAF SSPKYQKLRFVPR >&P450_Is243, 25458.m000013 37% to CYP392E6 mite TAEYTALLYATGVTALASFLLLFWYQHEGGRPSKVKLPPGPRGLPLLGNVTVSSYDFHYRKCTEWAQKYGPIFRFCIGKV NVVVLNDFASIKKYLSMEATLIRSQRSIFEGVTMGMTTLSGPAWVENRRFCLRVLKDLGFGKKSMEEHIKEELRYLIARL VDAKGSP VPIREHLIPSTSNVITALLFGTTYSFDDPKRKYLDKLLARLFKIIMSGSAVDFQPYWLRKIADRIPYTRSYAL RKASLDLHAFIRERVKEHQETIDPNFHRDFIDGYLNKVTEHQDNPNSHFREAYILGNAIDFFVAGTGTVAASIQWHLFNC AKNPDTVQAVIQREIDGVIGREREPAWEDRSQMHFTMACIWEMLRWRTVVPLGLPRGTREDTFFDDYFIPKDTVVLANLL AVHRDPELWERPDEFDPTRFLKKDGTGLVKKPEHLIAFSVGKRMCPAEALTTVEIFLYLTTFLQKFRVLPAEGQQLPNLS SPALTVAHPSLQRLRFLPR >P450_Is030, VBpre_P005786 Same as P450_Is243 VPIREHLIPSTSNVITALLFGTTYSFDDPKRKYLDKLLARLFKIIMSGSAVDFQPYWLRKIADRIPYTRSYALRKASLDL HAFIRERVKEHQETIDPNFHRDFIDGYLNKVTEHQDNPNSHFREAYILGNAIDFFVAGTGTVAASIQWHLFNCAKNPDTV QAVIQREIDGVIGREREPAWEDRSQMHFTMACIWEMLRWRTVVPLGLPRGTREDTFFDDYFIPKDTVVLANLLAVHRDPE LWERPDEFDPTRFLKKDGTGLVKKPEHLIAFSVGKRMCPAEALTTVEIFLYLTTFLQKFRVLPAEGQQLPNLSSPALTVA HPSLQRLRFLPR >&P450_Is015, VBpre_P005174 40% to P450_Is243 KKGGATLPPGPWGIPLLGNLAILRKDFHRKQGIEWAKKYGPVFRIRIGVRNIVLVSDFELIKEILCKKECLFRPQRWVFK HIGGVGSLNGKAWQENRRYCVKSLRELSSGKKSMLEHVREEFQCLRDKVADARGQPLRMRPLLLPAVANTIAALVLGSRY ASSDPRLDQLEQHLETFVRIFFSVPPVNPLPSWLDWMSPYIPILGEYKGSKFARDILKFVG >&P450_Is312, 35065.m000009 NEINDRLETVDSDINPHFIKGYLALVTQHNENPKSNINARALHGNMVDILVAGSASVAASILYILLYCAEKPDTVQAKIQ EEIDRVVGSGRTPTWEDHRFMPYSMAVVWEMSRWKTLTTLDLPREVDEDVFLSGYVIPKGTIVVANFWAAHFDPKYWKNP EEFDPSRFMTPDGSALLPRPEFLIPFSI GKRMCPGGALATIQIFLCVTTLLQAFRVLPVEGASYSVGSDLFADLLMQGLCFVPRMPE >P450_Is130, VBpre_P004854 Same as P450_Is312 VKLGVQSMVIVNDFELIKEILCKKECLFRPRTWVFKDVGGIASLNGKAWQENRRYCVKTLRELSSGRKSMLEQVREEFQY LREKVTETKGHPIMVRPFLLPCVTNNIAALLLGSRYDFNDPRLNRLDTLLEAFLRIFSGVSPVDPLPKCLKWIAPYIHCL GGGNGLELQQKFFKFIR NEINDRLETVDSDINPHFIKGYLALVTQHNENPKSNINARALHGNMVDILVAGSASVAASILY ILLYCAEKPDTVQAKIQEEIDRVVGSGRTPTWEDHRFMPYSMAVVWEMICCANISGTYLTSFRVDEDVFLSGYVIPKGTI VVANFWAAHFDPKYWKNPEEFDPSRFMTPDGSALLPRPEFLIPFSI >&P450_Is279, 34759.m000141 34% to CYP392D4, 32% to CYP2C8 human MDIILVLVATLILSALLFKIKSKATDKKRALAPGPTGLPILGYMPFLGPRPHVKYKKLSEVYGPIVRVKMGSVDVLVLHT VQSIKEGLNKDEVLARPPYFRLRSLGMDGIVTMNGQPWLDNRRFCLHVLRDLGFGRKSMEEHIKEEILQLCDVLRSWDGK PKAVTDVLTSSVSNNITALLFGERFHYDDPRRHFLDTKAVKFALNASFVSALDFLPSVRNLVSYIPSSKFGISKDVLKSV HDFISEQVREHSKTLEAVVNTDFIGAYLKKINENNGGNASFNPQTLTGNALNFFGAGTNTVRASMLWHLLNCARDPEGVQ RKLQQEVDKVVGRVRAPEWEDRHKMPYTMAAVWEMLRWRTVAPLGVIR V >P450_Is047, VBpre_P008490 Same as P450_Is279 MDGIVTMNGQPWLDNRRFCLHVLRDLGFGRKSMEEHIKEEILQLCDVLRSWDGKPKAVTDVLTSSVSNNITALLFGERFH YDDPRRHFLDTKAVKFALNASFVSALDFLPSVRNLVSYIPSSKFGISKDVLKSVHDFISEQVREHSKTLEAVVNTDFIGA YLKKINENNGGNASFNPQTLTGNALNFFGAGTNTVRASMLWHLLNCARDPEGVQRKLQQEVDKVVGRVRAPEWEDRHKMP YTMAAVWEMLRWRTVAPLGVIR >&P450_Is209, 24992.m000015 best match to CYP307A1 mite ESEAGIVYEERHRGYARGANGAEDHRFVMTFLFGLDGSEGLYITLVSMLVATFCAVLHLRERYYDRRRAPGPKGFPVIGS SHIIGRYPNVWDAFGDLRRQYGDVFALTLGSKRCLVVSSVEALREVLVAKAADFADRR TRCATTPSSRATGTFVSRCFTTPLAHPCAWVRESV EVQDKIRVEAIRAAGAEGASERVLTLADKPKLSFTESSVYEVIRIVNSPIIPHVCAKDTTVQGFYVP KGTMVMFNTNDINYSAELWEEPWSFRPERFLNEDGTVSKPRHFFPFGTGKRSCMGDGIVRATLVLGLSTLLRHFRI TLAEDQKPANFASFRCKV IFDKDPKLLFDPIS >P450_Is049, VBpre_P004973 Same as P450_Is209 MPWLKIVQNRELCLLKEKSLEIFHFTNAILDARDDEPKAADGPRDLLDVLLISLDAPGSLLNRLDVSIIIEDLIGGHSVI ANLWVWCLYILASHG EVQDKIRVEAIRAAGAEGASERVLTLADKPKLSFTESSVYEVIRIVNSPIIPHVCAKDTTVQGFY VPKGTMVMFNTNDINYSAELWEEPWSFRPERFLNEDGTVSKPRHFFPFGTGKRSCMGDGIVRATLVLGLSTLLRHFRITL AEDQKPANFASFRCKV SST >&P450_Is293, 34824.m000012 QYLLGNIAELLLGSASNSPSLIHWLLLVCAQNPDRIQAKIQKEVDDVVGRQRQPTWEDRKAMPFTMASVIEITRWKVILA IGLPRGVQKDTSIGGHHIPKGTMVLVNVMGVHRNPELWENPNEFDPTRFLVAEGTELSKKPEHHIAFSLG NAQIFA >P450_Is142, VBpre_P003005 Same as P450_Is293 IPVLHFIFPSILNVSSALLFGTRYALGDPKREHLTKHVEAYVQLFHSGTLIESKPRWLSRLEASLPFTRTGAMRRLRNVL LDFISGCGRRKNGFRYLSLSYVIKVLLNTVHIYEPKLNYPRT QYLLGNIAELLLGSASNSPSLIHWLLLVCAQNPDRIQA KIQKEVDDVVGRQRQPTWEDRKAMPFTMASVIEITRWKVILAIGLPRGVQKDTSIGGHHIPKGTMVLVNVMGVHRNPELW ENPNEFDPTRFLVAEGTELSKKPEHHIAFSLG RRKCPGEMLGNVELFLYLATLLQNFSVFPEEGTQLPDLGSLATTCCHPSVKKLRFVPRR >&P450_Is090, VBpre_P010581 81% to P450_Is293 GMANLNGEAWTENRNFSLRVLRDLGFGKTPMEENIKEELLNLINKIEGAKERAVPVFEFILSSTLNVTSLLLFGNKCVLD DPKRGNLVKHVEKFSELLHFDSIIECKPQWLSRLEASLPFTRTGAMRRTRQVLLDFISFRIERIESSWLRHFKCPPTVAI RATESASQVSLFICTE RHLLGNTAELFLGAASNAPSLIHWLLLVCAQNPDRLQVRIQKEVDDVVGRHRQPTWEDRKAMPF TMASVLEITRWKVMIPIGMPRGVQEDTSIGKYFIPKGTMVLANVMGVHRDPELWANPDDFDPTRFLTADRTELSKKPEYH IAFSLG KRNCPGEMLGNVQMFLYLATLLQKFSVLPVEGRPLPDLGCLTTTCSHPSVKELRFVSRQ >&P450_Is247, 25607.m000009 MSSVSNNITALVFGERYSHDDPRRQFLNPQLKMIARNASFAAAGDFLPAVWKLLSYSSLSKSRLFRQYMDGLVHFIR KE VNEHSKTLSANVNRDFIDVYLKKISENKGRNSSFNLHTLIGNVQNLFGAGSNTVSTSIEWILLLCARDPKGVQRRLQQEVD NVLGRERAPGWEDRHRMPYTMAVIWETLRWRTITPLGLIREAERDTSIGSFHVPAHTAVIFNFWAIHHDPEIWRHPFDFD PTRFLNADRTRLLPKPAALMPFTAGRRMCPAETLAMMEIFMYLSTLMQTFTVLPKEGETISLEIHQGISTIPLHTQELRF LPR >P450_Is057, VBpre_P003769 Same as P450_Is247 GIASISGQAWVENRSFMQVLRDLEFGRKSMEDHIKGTTAFCIAELCDVLKSWNSRPAPTADVI MSSVSNNITALVFGERY SHDDPRRQFLNPQLKMIARNASFAAAGDFLPAVWKLLSYSSLSKSRLFRQYMDGLVHFIR Q VNEHSKTLSANVNRDFIDV YLKKISENKGRNSSFNLHTLIGNVQNLFGAGSNTVSTSIEWILLLCARDPKGVQRRLQQEVDNVLGRERAPGWEDRHRMP YTMAVIWETLRWRTITPLGLIREAERDTSIGSFHVPAHTAVIFNFWAIHHDPEIWRHPFDFDPTRFLNADRTRLLPKPAA LMPFTAGRRMCPAETLAMMEIFMYLSTLMQTFTVLPKEGETISLEIHQGISTIPLHTQELRFLPR >&P450_Is048, VBpre_P008496 75% to P450_Is247 MLDFIRKEADQRSKTLSPDENRDFIDAYLKKINESNGTNESFNLRTLMGNALNLFGAGTNTVRASIEWNLLYCARDPEGV QRKLQQEVDNIVGRERAPEWEDRHRMPYTMAFIWEMLRWRTPTPLGLIRTAERDTTMGGFHVPAGTVVLSNFWAVHHDPE VWEHPFDFDPTRFLNADHTVLLPKPAAFIPFSTGRRMCPGETLAIMEIFIYLTTLMQKFTVLPKEGETISMDIHEGITNI PLYSQELRFLPR >&P450_Is229, 31645.m000008 EDIFLDGYFIPKGTVVLSNVMAMSMNPGHWTRPFQFDPTKFLSPDGSGLIKKPEYLIPFASG >P450_Is189, VBpre_P013319 Same as P450_Is229 YVFRPGRGYESALALAVHTISENLNSGATWEHVQLDFRQAFDNREMQSLVNKIGEAKGSTISVREHLLSISFDVITTVLF GSTFKLNDHKHRELEKLLCGILQELHVDSFVDFKPVWLSNIMASVPFTKMAAMRNTMRLLREFIRERIKEHRNTPKDATF DFVDYYLNQIKEHKDDPDSYFRENHLIGCAMDFLVGGVASPPYFANWLLLVCAKSPDTVQSRIQAEIDRVVGSERQPKWS DRLEMPFTMACTVK EDIFLDGYFIPKGTVVLSNVMAMSMNPGHWTRPFQFDPTKFLSPDGSGLIKKPEYLIPFASG KRMCPGEALASVQLFLYTTCLLQKYSVLPEEGQELPCLDSVVT >&P450_Is045, VBpre_P005467 gray = same as P450_Is287 MPSIKQFYCSEDEQGRPVESIFYEVSRGTLGMFNLGGDASTKQRSFSLRVLRDLGFGKTSMEEHIKEELLDFVNGIDGTK ERGVPVLELILQSLMNVTSALLFGTRYPLGDPKRKYLAKLATDYMQRVHCAPIIQFKPQWLCRFEAKLPFTRTGAMRKCR LAMIDFIRDQVKQHEDTIQADVTRDFIDGFLKQVEKHRHETNSAFE VCHLVFNTVELFFGSSSNVPVLMHWLLLVCAQNPERVQARIQKEVDDVVGRDRQPTWEDRK >P450_Is287, 26650.m000013 MVS VCHLVFNTVELFFGSSSNVPVLMHWLLLVCAQNPERVQARIQKEVDDVVGRDRQPTWEDRK AMPFTMASVLEITRWKVTEPIGLPRG >&P450_Is087, VBpre_P008294 73% to P450_Is287 GMFTLNGEVWNENRNFTVRVLRNLGYGKTAMEEHIKEELLSLVKQIEEARGRAIPVFELVLSSVLNVTSGILFGIRYPPG DLKREYLTKHAAGYVEGIHCDPIIEWKPCWLSRLEASLPFTRTGAMRRHRKALADFIRDQVKEHEDTMEADVTRDFIDGY LKQVEKHQHDPNSAFR VSHLLGNSLELISGSATNTPALIHWLLVVCAHNPDRVQARIQKEVDDVVGRQRQPTWDDRKAMP FTMASVLEITRWKATTLFPMPRG VQEDTTIGKYVIPKGTMVLINLMGVHKNPDLWENPDRFDPTRFLTADGSELEKKPEH LIPFSLGKRKCPAEKLGYVEMFLYLSTLLQRFSVFPDKGTVLPDLESPTAPCRDTSLKKLRFVTRP >&P450_Is061, VBpre_P011639 89% to P450_Is287 IPVFELLLQSLLNNISALLLGTRYRLGDPKCKYLAKLAGDFIERIHCAPIIQFKPQWLCRVEARLPFTRTGAMRRCRLAM IDFIGDQVKQHEDTIQADVTRDFIDAFLKKVEKHRHDPNSAFQ VCHLVGNTVELFFSSSSNLPVMIHWLLLVCAQNPDKV QARIQKEVDDVVGRDRQPTWEDRKVMPFTMASVLEITRWKVTEPIGMPRG VQEGTSVGKYLIPKGTAVVANVMAVHRDPE LWENPDQFDPERFLTADGSELSKKPEHYIAFSLGKRICPAENLANIEMFLYLATILQKFSVFPDDGAQLPDLGCISTSWR HPSVTKLRFVRRR >P450_Is107, VBpre_P005300 Same as P450_Is294 IPVQEFLLPSTSNVITALLFGTTYALDDPRRKRLVQLVSTFVLRAISGPIV NWMPDWLTEICSALPFSRMGAIRGARQALVAFV TDRVQEHNLTLQKDINRDFIDGYLKKIKEHHNESNSPFQEKHLLGNAVDFYIAGTSTSASFIHWLLAVCAQKPDTV QSRIQREIDDHVGRGRQPAWEDSKKMHFTMASVFEILRWKNPLPVTNARGTQEDTILNGYIIPKGTMVISNIMAVHRDPT LWERPDDFDPTRFLSADGSCPAKRPEEIMTFSVGKRMCPADKLATVEIFLYVASLLQKFTVFPEEGKRLPCLDSLDVMKT HPAVRNMRFVSR >&P450_Is294, 35737.m000048 MCTTQEELRYLIQHISTASGTA IPVQEFLLPSTSNVITALLFGTTYALDDPRRKRLVQLVSTFVLRAISGPIVNWMPDWL TEICSALPFSRMGAIRGARQALVAFVR >&P450_Is295, 35737.m000049 MCTTQEELRYLIQHISMACGTAIPVQEFLLPSTSNVITALLFGTTLALDDPKRKRLIQLVTTYTSLVTSGPIVNWMPDWL SAIVSALPFSRMGAIRGARQELFQFVRNDDEDGRDTASDVSVTGVEMGLVVKRLRDPVPFPEDPGAEGTEGHLLGNAFDF YIGGTHTPASFIHWLLAVCAQKQDTVQSRIQREIDDHIGCERQPTWEDSKKMHFTMATPSGQPAMCVHDSWDEGEGRRHL RSSDGTFGVDRKMQQREGWRAGLKGLWDSTRAVTQGLGL >P450_Is108, VBpre_P005301 Same as P450_Is295 VQSRIQREIDDHIGCERQPTWEDSKKMHFTMA SVFEILRWKNPIPVTNPRGPQENTILNGYVIPKGTLVMSNIVAVHRDP TLWERPDDFDPTRFLSADGSCLAKRPEQIITFSV >&P450_Is326, 30852.m000013 MQ DEVRCLLSQILELKGEPVFVSKYTTPSISNNITGLLFGRGYDFDDPRRVYLDENMDGAGKALSSGSLVMFLPTWVYTI GAHLPFTRIYAIRRCFANIMNFTRAEEDTEIEGYFIPKGTVVIGNIWAVHMDPNLWKNPEEFDPTRFLDETGTKILPKPD YLIAFSVGKRMCPSEALSSSQIFVYVTSILQKFSVHPEDDTTKINLITDCVTFNTPKPQKLRFIRR >P450_Is120, VBpre_P013886 Same as P450_Is326 HFPAIACLEPRYLLEYPVAVAAILATIAAAAVWLQTRPQRKGILPPGPRGTPLLGFLPFLGKNLHVMFRDLAEIYGPVVR QVSNPFTHTIRVGTANIVALNSYDSIKKGLSNSAIQGRSRSVFLDQSKSPGVATLNGKVWLENRQMCLKLLRELGMGKTC LDEKIR DEVRCLLSQILELKGEPVFVSKYTTPSISNNITGLLFGRGYDFDDPRRVYLDENMDGAGKALSSGSLVMFLPTW VYTIGAHLPFTRIYAIRRCFANIMNFTRAEEDTEIEGYFIPKGTVVIGNIWAVHMDPNLWKNPEEFDPTRFLDETGTKIL PKPDYLIAFSVGKRMCPSEALSSSQIFVYVTSILQKFSVHPEDDTTKINLITDCVTFNTPKPQKLRFIRR >&P450_Is060, VBpre_P011603 62% to P450_Is326 LSSRATEDTHIRGFSIPKGTVVIANLWAVHMDPKLWTKPDEFDPTRFMDEEGRGILAKPEYLIPFSIGKRMCPGETLATV EIFVYLTSLLQKFRVLPEEGQNVCLDTETTSFNIPRPQKLRFLPRH >&P450_Is316, 20966.m000023 RFLFGN VLNFFGAGSNTVMVTIMWHLLTYAKYPDTVQAKIQREIDDVVGRERQPKWEDRNKMPFTMAAIWEMYRWRTIAP LGIPRAASEDVFYGEYFIPKGSMVLANLWTVHMDPKLWKDPQNFDPSRFLTKDGTELGPKPESLMPFSVGKRMCPGETLA TVEVFLNITTLLQKYNV LPEEGQVIDLSTKGAAVIVPETQKLRFIPR >P450_Is076, VBpre_P004015 Same as P450_Is316 insert in heme region VLNFFGAGSNTVMVTIMWHLLTYAKYPDTVQAKIQREIDDVVGRERQPKWEDRNKMPFTMAAIWEMYRWRTIAPLGIPRA ASEDVFYGEYFIPKGSMVLANLWTVHMDPKLWKDPQNFDPSRFLTKDGTELGPKPESLMPFSLWKIILLTHFHFARTPGK RMCPGETLATVEVFLNITTLLQKYNV >&P450_Is083, VBpre_P006726 56% to P450_Is316 NTSRGNLLNLFGAGTNSLNRSLAWHLLVCAANPDTSQRKIQKEIDDVVGQDRQPSWQDSHDMPFTVASIREMQRWKTVMP LAIPRRQAENIVIGGYVIPKGTAVMANLWAVHMDPNLWESPETFNPYRFLVLDDQTLKITPKPDYLIPFSIGA >&P450_Is217, 27380.m000014 MPATLASLTHKSSTLVIGFFRFQYAPVIACPAA GSLPGYQAVAVAAILVAITAAVWLRCRPERRRTLPPGPRGFPLIGFL PFLGRNHHVMFRDLAKIYGPVVRIRIGTANIVALNSYESIKRGLSNNAVQARYRSVFLEQTKSP EGQMRPQASDPSSSGLSRRSSLTAASVLTWGDSVFSRSCCKASG LDEAQYLVNRISELDGAPVLIRKYTVPSISNIITGLLFGSRYDYDDPRRTYL DENMAGAGRALSSGSLVIFLPTWMYTFWAHLPFTRIHDMRHAFQNILDYI R >P450_Is149, VBpre_P013779 same as P450_Is217 GSLPGYQAVAVAAILVAITAAVWLRCRPERRRTLPPGPRGFPLIGFLPFLGRNHHVMFRDLAKIYGPVVRIRIGTANIVA LNSYESIKRGLSNNAVQARYRSVFLEQTKSP GLGSEQFGPVSSEQLNCGLCVDMGRQRLQQILLQSLRPCESLTVRGGCSTASSYSQGPEGA SRGGSVCPQKDDGMVSRDCAVSGQWSLLVFLLPSRDEVVCTQLLGRRPHGHHVAGGGGG RGGSELNFPPRIGLTTSAEGSLRRGQIDLLLLCSVGGSFGTDRLHYSASCGVAAS LDEAQYLVNRISELDGAPVLIRKYTVPSISNIIT GLLFGSRYDYDDPRRTYLDENMAGAGRALSSGSLVIFLPTWMYTFWAHLPFTRIHDMRHAFQNILDYI >&P450_Is254, 21174.m000018 MSGIWRPSGNLLKGNVASFFGAGSETVRAAIDWLLLMSAVYPERQKKIQAEIDEVVGGTDRQVAWSDRNKMPYTQAFMWE VMRCKPVNPLSLMRY ASKDVTVGRFVIPEGSIVIGSIWSVFYDAQSWGDPECFRPERFLVDGGARAVKPDRFIPFSYGKR SCPGEVIANMEVFIYFTTILQHFNVEAPPNGPDLVFDEVLGISLRPKPQELIVRPR >P450_Is074, VBpre_P010554 Same as P450_Is254 this one has an insert in the heme region that is not correct VASFFGAGSETVRAAIDWLLLMSAVYPERQKKIQAEIDEVVGGTDRQVAWSDRNKMPYTQAFMWEVMRCKPVNPLSLMRY ASKDVTVGRFVIPEGSIVIGSIWSVFYDAQSWGDPECFRPERFLVDGGARAVKPDRFIPAEPTQVTARTSPRYLRLLAGK RSCPGEVIANMEVFIYFTTILQHFNVEAPPNGPDLVFDEVLGISLRPKPQELIVRPR >&P450_Is065, VBpre_P011850 86% to P450_Is254 ASKDVTVGGFVIPEGSIVIASFWSVFYDAKFWGDPECFRPERFLVDGGTRAVKPDCFIPFSYGKRSCPGEVIANLEVFIY FTTLLQHFNVEPPPNGPKLVFDEVLGLSLRAKPQELVFRQR >&P450_Is041, VBpre_P002441 38% to P450_Is254 AVHRLKTICLDLLLSGTAPTTALLCWALKLVARHPEAQVRAQGEMDAVLASPDQLGSLFSRDNLPFTEAMVLEVHRLASV CMLAPLRTNSEETTVGGFRIRAGSRVLANLWRAHRDPDFWSEPERFDPKRFLGDDGRPDKKDAFMPFSLGKRL >P450_Is282, 25338.m000014 FIDGYLQLMSEHKTDPNTSFNMPNLIGNALAVFAAGSQTTCTTLLWSLLSLADKVDTVQRKVQEEIDRVTEGRRAPAWSD RHDMPYTMATVWETQRWRTLSVMGIPRE LLQKFTVLPEEGRTVDFNYDTEGFCMPRSQNLRFMPR >P450_Is042, VBpre_P002559 Same as P450_Is282 KGPWEPHVNS FIDGYLQLMSEHKTDPNTSFNMPNLIGNALAVFAAGSQTTCTTLLWSLLSLADKVDTVQRKVQEEIDRVT EGRRAPAWSDRHDMPYTMATVWETQRWRTLSVMGIPRE SNNEFGDFHNELPDIDYFYYHPVTVIDKIERMVYTKRLSYDY TKTSLTFLFFVGKRMCPAENFANLEVFLYLAR LLQKFTVLPEEGRTVDFNYDTEGFCMPRSQNLRFMPR >&P450_Is310, 35684.m000065 MFFRINMGPGNVVILNDFNSIKKYFCKPEVLYRPSDWILTHSGVVGVATINGKAWVDNRRFCMQVLRDLGVGKKSMEKHI QEESQYLVEKIAETKGRATDAQEFLTPSVSNNITALVFGRRYPYENESRKYMDDRLERVIKVLSRGSIVGILPAWVFSIL VRIPSTTSNVIKTIADDLLGYASQKVKEHMESSELRTERDFIDRYLSKIKESDWNPDSSFTSK >&P450_Is205, 24905.m000012 MVFCDNEITGLATLNGQAWLDNRRICIRVLRDMGFGKKPMEEHIKEESRHLVKRLEGTDGSAVLVQGHVAASTSNNVSAL VFGSLYDFEDPRRKAMVENLEEFMKALGTGTMIEFFPEWIRAVVMALPFARVVAIKNVIRNLIELTSVDRVQYRIQEEID KIVGRDRQPTWEDRHRMPYTVAAIWEMYRCKPTLTLPRA >&P450_Is277, 26417.m000009 QPPGPWALPLVGNLGISDTVALYRRCVEWGKVYGPIFRIKIGVTNVVILSDVKIWKEFVAMEASLIRPHQSVVYQACRGY LGIATLNGEAWADNRRFCLRVLRDHGFGKTAVEDHIKQQLQSLANQIEDSKGTA IPIKECLFSISFNVISAVLFGSTYKDSDQKHRDVKTHIMNFMRVLAVNSLVDFYPVWLRTVMAC >P450_Is085, VBpre_P010987 Same as P450_Is277 IPIKECLFSISFNVISAVLFGSTYKDSDQKHRDVKTHIMNFMRVLAVNSLVDFYPVWLRTVMAC VPFTEVAKIRKKLAFA RKFISARVMEHRDTLEEDTTRDFIDGYLKQMMDQKDNPNSHYRECHLIGCALDFFAAGVAGVPLAIHWLLLICAQNPYKV QSRIHAEIDRVVGRERQPAWKDRLEMPFTMASIWELLRWRKEGLLGFPRGVKEDILLEGFLIPKGTVVLPNTTAMNRNPY YWKRPEEYDPTRFLTPDGTELLEKPEYFIPFSFGKRMCPGESLATVQLFLYATCLMQKYCVQPEE >&P450_Is274, 23487.m000018 FWVAGTNAINRSVIWHMLNCADKPGTVQKAIQDEIDEVVGRERQPAWNDRYRMVYTMAAIWEMLRWRPISPMGLPRGTSE DVIIGGFTIPEGTIVMANLWAVNMDSSLWVHPEKFDPYRFIEEGRAKLKPKPEYFIPFSLG >P450_Is003, VBpre_P000883 Same as P450_Is274 SVRYLPGNILS FWVAGTNAINRSVIWHMLNCADKPGTVQKAIQDEIDEVVGRERQPAWNDRYRMVYTMAAIWEMLRWRPI SPMGLPRGTSEDVIIGGFTIPEGTIVMANLWAVNMDSSLWVHPEKFDPYRFIEEGRAKLKPKPEYFIPFSLG WLFFYTYSLES >&P450_Is264 27926.m000028 DFVGAYLKRSEEQQNRSESNLNKNYLIGNAVSLYMAVSHSVPSFVHWHMLNCAQSKDTVQAGIHEEIDRVIGRDRPPAWE DRLAMPYTMAVLWEMYRCKPNSTLPRSVGEDILLNDYIIPKGTVVMPNFWAVLMNDSLWENPGKFDPSRFLSEDGSRLLD RPEHLISFSLG RRMCPGEPLATMEIFMYLTTLLQKFVVLAEEGRPLSIDFKNATMDDYVEQKLRFVLR >P450_Is157, VBpre_P013242 Same as P450_Is264 IKVGVVDVVVLNDFESIKNFLCKKEGLYRPENMVFSNVGVNGVATLNGPAWLENRRISMRILRDLGFGKKGMEGLVREET RQLVEKLVKTNGLPIVTLKQFTPSASNVISRVLFGERDASTSPRGMAMVENLDKFSKALGAGSLIEVLPQWARHLVLLLP FTRSVALRRFVQNLIELGSQYVTDHEDAKKSHPANE DFVGAYLKRSEEQQNRSESNLNKNYLIGNAVSLYMAVSHSVPSF VHWHMLNCAQSKDTVQAGIHEEIDRVIGRDRPPAWEDRLAMPYTMAVLWEMYRCKPNSTLPRSVGEDILLNDYIIPKGTV VMPNFWAVLMNDSLWENPGKFDPSRFLSEDGSRLLDRPEHLISFSLG WYPFK >&P450_Is248, 24138.m000012 DQIREHKNTLPQDFNRDFIDGYLKKTMEQQSKTESYFDERHLLGNISEFLVTGTGPASMRIFWMLHICAQNPDSVQSRIQ KEIDDVIGLQRQPKWEDRQAMPFTMATLKETMRWKTLRPIGGSRGIQENTFIGDYFIPKGTIVLLNSRTVHRNPDYWNNP DEFDPTRFLTSDGTELVKNEESFLAFGAGRRNCLGQNLGYVQLFLYITTLLQKFSVFPEDGHQAPDIGSLDTTTDDPRLQ KLRFVLR >P450_Is018, VBpre_P009005 Same as P450_Is248 GVSNLNGKAWTQNRNFSLRVFGDLGFGHPSMEDHIMEELQDLVSQISDNAGGFINLKGYVIASVANVIAALLFGRRFNWG DDKHDFLVKHLRNVLDGFESGLVVENKPNWLSTITASLPISKPGVMRRSRILLQEFVR DQIREHKNTLPQDFNRDFIDGY LKKTMEQQSKTESYFDERHLLGNISEFLVTGTGPASMRIFWMLHICAQNPDSVQSRIQKEIDDVIGLQRQPKWEDRQAMP FTMATLKETMRWKTLRPIGGSRGIQENTFIGDYFIPKGTIVLLNSRTVHRNPDYWNNPDEFDPTRFLTSDGTELVKNEES FLAFGAGKRNCLGQNLGYVQLFLYITTLLQKFSVFPEDGHQAPDIGSLDTTTDDPRLQKLRFVLR >&P450_Is233, 24324.m000014 DTLHGSVV DLLIAGSSTVAATILYILLHCAANPDAVQARIHEEIDAVVESCRSPKWEDHNGMPYTMAVIWEMYRWKTVSTLNLPR >P450_Is044, VBpre_P005417 same as P450_Is233 73% to P450_Is312 DLLIAGSSTVAATILYILLHCAANPDAVQARIHEEIDAVVESCRSPKWEDHNGMPYTMAVIWEMYRWKTVSTLNLPR EVAEDVVLNGYLIPKGTIVVANNWATHNDPRYWKNPERFDPSRFLTPDESQLLPRPEYLMPFSIG >&P450_Is220, 31142.m000009 AEEDVSLNGYRIPKGTVVLANFWAVHFDPKYWKNPEEFDPYRFLTHDESALLSKPEYLLTFSIGKRMCPGELLATVDVFL CVTTLLQKFRVLPEEGTSFSVATDHYTDLLAKRLCFLSRLPE >P450_Is084, VBpre_P006785 Same as P450_Is220 MLHFLLAGVGSLNAKAWQENRRYCVKALRELSTGRKSMMNHIREEIRCLRDKVAEAKGGPMTIRSLLISCVVNVIAEMVL GSRFEFNDPKLAELEQHLDTFAKLISGVTPVNPLPKCLKWISAYIPVLGGNKGLELARDLTNFFRYRSLRDFDNACNILT FLACAVTLYCLLSHTVDTLHGNMLDFFVAGTASSAATISCIIYHCANQPDTLQAKIYGEIDRVVGSCNTPTWEDHQAMLL YTMAVIWEMQRWKTLNPFNLPRL AEEDVSLNGYRIPKGTVVLANFWAVHFDPKYWKNPEEFDPYRFLTHDESALLSKPEY LLTFSIGKRMCPGELLATVDVFLCVTTLLQKFRVLPEEGTSFSVATDHYTDLLAKRLCFLSRLPE >&P450_Is211, 19705.m000018 KLYSSVYLSNQKFSLSLSLPSTEENLLGNTAEFLLSATGPSSTRIFWCLHICAQNPNSVQTKIQKEIDDVVGRHRPPTWE DRKQMPFTMASLKETLRWMSLGSIGCSRGLLEDTFIGDYLIPKGTIVLLNLRAVLRNPVHWNNPDEFDPARFMTNDSTEV GKNENAFVPFGVG >&P450_Is208, 24966.m000014 DHLLGNVL SFFVAGSTTVRSAIQWNVLYLASQPDNLQLMIQREIDEVVGKDRSPSWEDHENMPLTVATIWEMFRWRTDST FGGPREIIEDIVVGEYSIPKGTMLLPNVRAVHSDPRLWKNPEDFDPFRFLSEDGTCLIPKPEYLIPFSLGT >P450_Is066, VBpre_P011853 Same as P450_Is208 SFFVAGSTTVRSAIQWNVLYLASQPDNLQLMIQREIDEVVGKDRSPSWEDHENMPLTVATIWEMFRWRTDSTFGGPREII EDIVVGEYSIPKGTMLLPNVRAVHSDPRLWKNPEDFDPFRFLSEDGTCLIPKPEYLIPFSLGT >&P450_Is313, 34498.m000012 HITK SINIASTNSCFRYSNVNSWLSRPFVCKDKCSFSRTAHALRGHVIDL LLAGSSSVAITMLCILLHCADNPSTIQARIQREIDNVVGVDRSPTWEDHLLMPYTMAVIWEMTRWKTLNRLNLPR >P450_Is028 VBpre_P005777 Same as P450_Is313 IVLRRTLLHSVSNNIATLLLGSRYQLNDPKQKQLEKLLMTFEILFTKVPQVEPLPKKISGKLASTKHEIHKTSRETRDYS KDAV SINIASTNSCFRYSNVNSWLSRPFVCKDKCSFSRTAHALRGHVIDLLLAGSSSVAITMLCILLHCADNPSTIQARI QREIDNVVGVDRSPTWEDHLLMPYTMAVIWEMTRWKTLNRLNLPR EAEEDFILNGFLIPKGTIVIANLWAAHMDPKYWKN PEKFDPSRFLTQDGSALLPKPECLIPFSTGKRMCPGEFVATAQIFLCITTLLQEFRVKSEDGSSFCVAS >&P450_Is291, 34809.m000003 AEAKGQPVLMRSLLLPSVSNNIAAFVLGSRYDFNDPRLKKLHKYMEDFVRIFSDVSPVDPLP >&P450_Is290, 34916.m000005 AGPAEWLALLLTTAALVLAYFAATDWFSRFTSPVGKVLVPGPRGLPFVGNLFSMDNKFHFDKCVTWAKKYGPVFR >&P450_Is265, 27941.m000011 LGVLLVQYVWDQLKRNFKKGLPPGPYGLPFVGYLPFMPKDGHRGVEALKDKYGTVFG >&P450_Is263, 19508.m000016 EEIEYLIGKISDVKGRPIPVEQYLLPSVSNNVSALVFGHRYDFDDPKRKMLDGILDTGMRCLAAGAVITFMPRGFRTLTT MCFTRFGALRPLVQKLTEFI >P450_Is075, VBpre_P003976 same as P450_Is263 MTLNGTSWMDNRKYCVRLISSPAYGHKDMETQVQ EEIEYLIGKISDVKGRPIPVEQYLLPSVSNNVSALVFGHRYDFDDP KRKMLDGILDTGMRCLAAGAVITFMPRGFRTLTTMCFTRFGALRPLVQKLTEFI CQEEGLGGKEHRKLRENNFVDGYLQLISEHNEDPNTSFN >&P450_Is249, 24165.m000009 EHESTLHPDINRDYIDGYLKKMKERHSEPFSSFQENYLLGNTVESLVGGSGPSSFRVFWLLHVCAQNPITVQSRIQKEID DVVGHRRRPTWQDREAMPFTMACLQEILRWKSLTPVGNQRG >P450_Is191, VBpre_P006471 Same as P450_Is249 LFRDQIR EHESTLHPDINRDYIDGYLKKMKERHSEPFSSFQENYLLGNTVESLVGGSGPSSFRVFWLLHVCAQNPITVQS RIQKEIDDVVGHRRRPTWQDREAMPFTMACLQEILRWKSLTPVGNQRG VLEDTFIGGYLIPKGSTVLLNSMGVHRNQEHW ETPDEFDPSRFLTNADTNLAKKYDHFVPFGLGRRNCPGKTLAYVQMFLYVATLLQRFRVFPEDEDRLPCLDSLDVTPAHP SVQKLRFVLR >&P450_Is239, 30404.m000007 NNLLGNAAEFLLSGTGPTSSQIFWFLHICAQNPNSVQNKIQKEIDDVVGPHRQPTWEDRKKMPYTMASLKEGLRWKAIGP IG >&P450_Is231, 21054.m000016 MVLIKDLDAIKQIQISKFKDCSARGMSHLLEHCTDEFLEVLDTACTQDVPINTIAVCRTFAANTMLRTGLSFRMDERDKT GRDVRDSVKKLTLANIRVFQGGLLHLLSS CYP3 clan (162 sequence pieces, 115 different non-overlapping sequences, some will join) >&P450_Is238, 24553.m000207 32% to CYP3A4 human KRRQHFNYFKKLEIPGPEPSIFFGNMMELYKKTPTVAYREWIDKYGKVVGYFNGYRPVLLVADLELLKNVQVKDFQDFID RSLLFQSKRPPSPQNKSLIQLTGKRWKEVRSVLTPSFTSNKLKMMSAGVIETIQELMTKIDQKAKTGSEFEIGDMYQALT LDVICRSAMGINYNLQQHPNHSFLVSSRMLFSSTFSIIAVLLTAFPELEFFLRYLNDFRMKSLNNGVHPFREVQEKCKSI VMQRQMNNVQVHQKDLLQHMIEAKQSRVDVGSVTSDQLTAADDNDLEQKPASQLANGFTHSSKAVLDDDDITQNAFLVLI AGYETTSNTLTLVTHMLVNYPDVQEKVRRELLSVIEQDEEITYSTVQKLPYLNCVVSETMRLYPPIFAFVTREAVVDKQY GKLKIPVGTAVMAAIEYIHRDPDNWKDPNIFDPDRFLPQNKHFDPLAWQPFGAGPRNCIGMRFAHMELRLTLANVLRKYR LEATENSDVDPPQIDMNPLVLRIKKGVNVRAVRL >P450_Is026, VBpre_P011063 Same as P450_Is238 MDPTKVMWELVAACSIVFVVRWFV KRRQHFNYFKKLEIPGPEPSIFFGNMMELYKKTPTVAYREWIDKYGKVVGYFNGYR PVLLVADLELLKNVQVKDFQDFIDRSLLFQSKRPPSPQNKSLIQLTGKRWKEVRSVLTPSFTSNKLKMMSAGVIETIQEL MTKIDQKAKTGSEFEIGDMYQALTLDVICRSAMGINYNLQQHPNHSFLVSSRMLFSSTFSIIAVLLTAFPELEFFLRYLN DFRMKSLNNGVHPFREVQEKCKSIVMQRQMNNVVHQKDLLQHMIEAKQSRVDVGSVTSDQLTAADDNDLEQKPASQLANG FTHSSKAVLDDDDITQNAFLVLIAGYETTSNTLTLVTHMLVNYPDVQEKVRRELLSVIEQDEEITYSTVQKLPYLNCVVS ETMRLYPPIFAFVTREAVVDKQYGKLKIPVGTAVMAAIEYIHRDPDNWKDPNIFDPDRFLPQNKHFDPLAWQPFGAGPRN CIGMRFAHMELRLTLANVLRKYRLEATENSDVDPPQIDMNPLVLRIKKGVNVRAVRL >&P450_Is235, 31391.m000006 MSGSVISTVEELVGRVGQMAEKDEDFEIGPMYQALTLDVICRSALGINYNLQQNPKHPFLLSSCMLFGSTFSFIAVLL >P450_Is104, VBpre_P010618 same as P450_Is235 MVQIKDFQDFLDRALLFQTKRPSSPHNKSLMQLMGARWKEVRSVLTPSYTSTKLKM MSGSVISTVEELVGRVGQMAEKDEDFEIGPMYQALTLDVICRSALGINYNLQQNPKHPFLLSSCMLFGSTFSFIAVLL ASFPGLEGPLRVLNGWRLRRMNNGVH PFLDVQEKCKSIVTQRQKVSVELPLQKDLLQLMIEAKQSRVDVGSVTSDQLTAADENEHELKTHIQGSNGL >&P450_Is216, 27341.m000009 FETTSNSMAFITHMLVNYPEVQEKVRQELLSVLGPDEEITYNTIQKLPYLHCVVCETMRMYPPIFGFVTREAAVDKQYGK LKIPAGTAV MSAVEYIHNDPDNWDNPHVFDPDRFLPENKQKFNPLAWQPFGAGPRNCIGMRFAQMEIRFTFAHILRKYRLVPTENTEK VRSHL >P450_Is153, VBpre_P002014 Same as P450_Is216 LLRPPPQLTFVLLQR FETTSNSMAFITHMLVNYPEVQEKVRQELLSVLGPDEEITYNTIQKLPYLHCVVCETMRMYPPIF GFVTREAAVDKQYGKLKIPAGTAVMSAVEYIHNDPDNWDNPHVFDPDRFLPENKQKFNPLAWQPFGAGPRNCIGMRFAQM EIRFTFAHILRKYRLVPTENTEK >&P450_Is077, VBpre_P004038 89% to P450_Is216 MSAVDYIHHDPDNWEDPYTFDPDRFLPENKHKFNPLAWQPFGAGPRNCIGMRFAQMEIRFTFAHILRKYRLVATENTEKD PPKIDMNPLVLRIKNGVNVKAVPL >&P450_Is280, 25181.m000016 (note: two P450s fused) GRNRRILTNAEIQANAIVFLIAGFETTSTAMTFTTYLLAKFQDVQDRLRKEITAVLERDGKFTYDNVFGMRYLDQVISES LRFYPPVTGFTTRTCQHDYEQNGLKIPAGMNVVIPPYQLQHDPALWSEPEKFDPERFSAKNKGSFDPMAFQPFGNGPRNC VGMRFAQLEMKLTLAKMLAKYKFLLDKRHVE GKFNYDNVFSMQFLDQVITESLRFYPPVVGFVTRTCQHDYHYKDLKIPA GLSIVIPQYQLQHDPNLWSDPETFDPE RFSAENKGSFDPMAFQAFGNGPRNCVGMRFAQLEMKLTLAKMLAKYKFLLDDR HLEEPAGPKFRHLARFDSTTIVSYLANSNFSDKVQHRTCPGTRTTC >P450_Is131, VBpre_P004885 Same as P450_Is280 MKAPSDNIKFGIMPIIDMRRSNPEARREDLLQLLLNAEAEEGAAVDVHQLTVGYEGETSQSAESKSS GRNRRILTNAEIQ ANAIVFLIAGFETTSTAMTFTTYLLAKFQDVQDRLRKEITAVLERDGKFTYDNVFGMRYLDQVISESLRFYPPVTGFTTR TCQHDYEQNGLKIPAGMNVVIPPYQLQHDPALWSEPEKFDPERFSAKNKGSFDPMAFQPFGNGPRNCVGMRFAQLEMKLT LAKMLAKYKFLLDKRHVE EDHLKLGSSFALCYPLDGAWLKVKKL >P450_Is033, VBpre_P013452 Same as P450_Is280 MSCSNDQLSQANTTRRRRKHFSFFKDIGIPGPMPSLFSGNLSELIEKGSRLSFEEWVKKYGDLVGFYNGAEPMLIVKDLE LIKRIQIKDFSNFRGRGISSLMDICTDEFLEVLDSLHDQDEAFEIRQVFQKLSMD GKFNYDNVFSMQFLDQVITESLRFY PPVVGFVTRTCQHDYHYKDLKIPAGLSIVIPQYQLQHDPNLWSDPETFDPE >&P450_Is043, VBpre_P002360 67% to P450_Is280 I LMFQGKFSYDNVFSMRYLDQVISESLRFYPPVTGFITRTCQHDYEYNGLKIPAGISVLIPPYQLHHDPNLWTEPEKFDPE SSASNKVNDGDTLQTRTAWRGPAHAPAHVPLNV DMKLTLAKMLAKYRFLLDERHVKEDSLKIGSTFIFCYPQEGAWLKVEKI >&P450_Is184, VBpre_P011199 85% to P450_Is043 RRRSDFLRN LMFQGSFNYDNVFRIRYLDQVISESLRLYPPVTGFTTRTCQHDYEYNGLKIPAGMSILIPPYHLHRDPNLWSEPEKFDPD RLTCRCSVQLHTDPSVIIVPVIKVYDRSKSLNFSRR NMKLTLAKMLSKYKLLLDERHVKEDCLKLGSTLIFCYPQDGVWLKLEKIGMSS >&P450_Is081, VBpre_P009105 60% to P450_Is043 AVLTFTAYLLAKHQRIQDRLRAEIASVMERDCHFTYDNVFAMRYLDQVISESMRIYTPFVGFITRTCQREYNYNGLKIPA GLSILIPAYQLHHDRDLWNEPNKFDPDRIERYSHTMKRGLHWNVHQLPKFQLRQLTLAKLLAKFRIKLDERHIKEDHLKL GSTFIFSYPQDGVWLEFEEI >&P450_Is144, VBpre_P003015 Gray regions same N-terms different This N-term 55% to Is244 MWVLNRRRQHSLFARLGIPGPAPDLFSGNWVQLKKDPLEVMEHWIEKHGKMFGYYVGEIPYVAITDLEMIKQCFVKEDNV VCNRPSLIVSIEPFGSSLVGLSGDEWKRVRTVLNPIFTSVKLKAVTEIIRRCADEMLEILDDYAERGCVVDMTKVSKGLS LDVITKSAFAWQ VDCQRNPSDPLLLAVQRIFNDSDNFLILSAVRFPALRKAMERIFLYSSYFKMITHISDKILKVLELRQ SGQSPRANDMLQLMLDAQTGSEDANVDFKKRAKAIEDRHLLANCFIFLAAGFDTTASSLSFVMHLLAKYPEEQELVFDEI QKTFPGDAELTYDGLQQLKYLDMVICETLRMYPPVVMFTSRHCKEDTMVMGQLFPAGVNVLVPVWHIHHDPELWPDPQRF DPKRFDGEKSRNSAAYLPFGIGPRMCIGKRFALLELKLAICKIVRKYKVFPCEQTQDPLKFSVPTVVLHPKSPICVKLQQ R >P450_Is144, VBpre_P003015 same as P450_Is144 MWVLNRRRQHSLFARLGIPGPAPDLFSGNWVQLKKDPLEVMEHWIEKHGKMFGYYVGEIPYVAITDLEMIKQCFVKEDNV VCNRPSLIVSIEPFGSSLVGLSGDEWKRVRTVLNPIFTSVKLKAVTEIIRRCADEMLEILDDYAERGCVVDMTKVSKGLS LDVITKSAFAWQVDCQRNPSDPLLLAVQRIFNDSDNFLILSAVRFPALRKAMERIFLYSSYFKMITHISDKILKVLELRQ SGQSPRANDMLQLMLDAQTGSEDANVDFKKRAKAIEDRHLLANCFIFLAAGFDTTASSLSFVMHLLAKYPEEQELVFDEI QKTFPGDAELTYDGLQQLKYLDMVICETLRMYPPVVMFTSRHCKEDTMVMGQLFPAGVNVLVPVWHIHHDPELWPDPQRF DPKRFDGEKSRNSAAYLPFGIGPRMCIGKRFALLELKLAICKIVRKYKVFPCEQTQDPLKFSVPTVVLHPKSPICVKLQQ R >&P450_Is181, VBpre_P005166 49% to P450_Is144, 32% to CYP3A4 human MESALWMLWMSIFAFLATCVAVWLRERRHRHGFFKRMGIPGPEPDLLFGNWQQLRKDRINVMEDWIAKYGKTFGYFKGAA PFFIISDLEMIKQCFVKEAHIFYDRPDPSILVEPYNQTLLFLKGDEWKNVRTLMNPSFTSAKMKLMTGIIDACVDEMVRV LDKKAKDGAPVDVSKVSCGLSLDVVAKCALAWQVDCQKSPDDPFVLKLRNIVQNSETPVTNTFVAFASLRKLAALIYPFT SHAKDTFSIVENLRRIVELRRRDSKNRRVDMLQLLLDGQAGKLTEGNTVNAEKKGGKSRLLMSDDRLLANSLLMLLAGFE TTAMSLTFMIYLLSQHLDEQETLYNELVATSAINDLNYEKLMRLRRLDMVVRECFRLYPPVVLFLSRACNADTNIMGQFF PKGSHVMVPVWHIHHDPEIWPDPFKFDPGRFGPEAPPHHPAAYLPFGVGPRICLGMRFALLELKSALCKIIRKYRIVPCE DANAPPELTVPIYIINPKHPIKVMLQRR >&P450_Is305, 35813.m000019 44% to CYP41, 38% to CYP3A5 human YVARHKNYWKNQNVPHEKYSIFGHTRRMMSKTFHELDQERYIKYGKVYGMFEGGKPSLFVADPELIKQILVKDFLKLPNR RSVKFHNPLLDNLMSVVSYKRWKVIRSVSTPAFSSAKLNKMFSLIESCIDVTKRHLIDAAEKEQDLELGHFYGNYTLDVI ARCAFGTTMDSHSDQTNDFVRMSKIISGGKKNLALVLTFVFPALAKLLKLKLFNEESVMYYKDLSSAT METRRKTKTKQD DFLQIMIDAQERNRTLDVSQGGEEDAVKLFDIDSKLTDEAPLSSKTLSEEEALSQCMMFILAGHGTTSSVIAFSLYLLAL NPEAQNKLRKEVDVCVKENGPKPSMDAIDKLQYLHGVVSEALRIFPPASRLERETTEDYVLGNTGIKVPKGCVVAVPVWA LHHDPQYFPDPHSFKPERFSKENVDSIPPYVYLPFGAGPRNCIGVRLGLRAVKMALFHSICNVEFVRTAKTKVPLELFKG FGVISSSDITVGVRKRTS >P450_Is169, VBpre_P003856 Same as P450_Is305 METRRKTKTKQDDFLQIMIDAQERNRTLDVSQGGEEDAVKLFDIDSKLTDEAPLSSKTLSEEEALSQCMMFILAGHGTTS SVIAFSLYLLALNPEAQNKLRKEVDVCVKENGPKPSMDAIDKLQYLHGVVSEALRIFPPASRLERETTEDYVLGNTGIKV PKGCVVAVPVWALHHDPQYFPDPHSFKPERFSKENVDSIPPYVYLPFGAGPRNCIGVRLGLRAVKMALFHSICNVEFVRT AKTKVPLELFKGFGVISSSDITVGVRKRTS >&P450_Is168, VBpre_P003855 55% to P450_Is305 FTMVFRYLARFRNHWKDQHVPHESYALLFGPMLKMLYQPFHDIDIERYRKYGKVFGIFESGRPSLFVADPKLVKQVLVKD FLLLPNRRTTKFLHPLLDNMLFVVPFDRWKVIRRISTPAFSSGKLRKVMVHVESCTRSTIKHLREAAERCEDLNLSQFYG NFTLDLVARCAFGTMLESHSDQSNEFVSYGTKAFGEGISFASVIFFLWPGLAKLLRLKFFNQKTLIYFKKLSLSVMNNRR RERT >&P450_Is009, VBpre_P012339 58% to P450_Is305 LIVLGNRIDRSTTEDYALGDTGITLPKGCTITVPIYAMHRDPLNFIDPDSFIPERFTEDNAASVLPYTYLPFGAGPKGCL GMNLALLAVKLCLMYSLRAIEFVRTSKTKVGQPCCNFL >&P450_Is114, VBpre_P006307 72% to P450_Is223, MLYPAVILVFTVLILLVVKVLRWRRRTFCYFKDLGIPGPSPNLIWGNLREYHEKGLFQALDKWCKQYGDVFGFYNGDVPM LVVKDLEFLHYIFVKSSSNFTARG >&P450_Is124, VBpre_P006873 61% to P450_Is223, MAYQPFGDGPRNCIGKRLALLEIIYTGARMVQKFKLTLGESQKGTMKMEFHGMVSSPGLGPWIKFERL >&P450_Is119, VBpre_P006312 56% to P450_Is223 MMPHVSEQAEVLIDILGEVSDLGRELSTFETFQALAMDNVGRTFFGLNSTFQHNVQDAFIAKALNVIPQMMTGPFHFIAH CTTSFGRIVKPLAWLNKLLGTFALENFSRDIAKIVEQRRKNPSLRRNDVLQCLIDAEERPDDKTNEKSAKNFTDDRLSLL IYCSFQTISISLCYATFLLAKHPDIQDKVRKEVSEAVAKSGSLSYETVMHKLWYLGQVLNETLRMYPPSLTFMTRAAKND FEYNGTKFKAGLSIMSPVLHVHMDSRYWPEPHKFNPDR >&P450_Is117, VBpre_P006310 64% to P450_Is223 GSLDYETVNQKLKYLGQVINETMRIWPAALTTERGPCKTLVNPLVQYPAG >&P450_Is138, VBpre_P002172 45% to P450_Is223 RKKTFGYFKDLGIPGPEPSIIWGNLAEYQRNVSYVRLYIVSDLLNHFAAVKTKQKTATLKVVYIIIFLFQVTMRTDQVHP SLGESLIHAKGSQWRFLRSCPSPEFTSHKLKQMMPYLVEQGDIFINQLDKLADERREESMLDAFQALSMDFICRAAFGID TDFHHNKKNPFYVQAEGVIP >P450_Is116, VBpre_P006309 same as P450_Is223 MLAHCTTSFGVLAAPIFWLNWTFGSFSFVRVSEEVAKVIELRKKNPELRRTDILQNLID AEYEEQATTRTSSDKTTNTNQKD VCNEFWLVTHR FETTATTLCYLMFVLGKYPDVQEKVREEVKRAVDDSVSFASI >&P450_Is223, 34549.m000042 29% to CYP41 tick, 31% to CYP3A4 human MIVTVVLSTLLVLLAINLLRWRRKTFSYFKDLGIPGPKPSLIWGNLWEYHQNGLFRALDKWCKEYGDIFGFYNGDVPMLV VKDLEFLKHVFIKNFSNFTDRGITMRTDEMHPFVGNAVAHAKGSHWKSIRQSISPWFTKLKLKLMMDHITQVGDVFMEVL GKKADQGQEVCMFEATQALTMDYIGRAALGIDNSFQNDQKNPFLVTAQRAFREIMTGPFHMLAHCTTSFGVLAAPIFWLN WTFGSFSFVRVSEEVAKVIELRKKNPELRRTDILQNLIDAEYEEQATTRTSSDKTTNTNQKDISKTRTLSSEEVIINTTV LFTAGFETTATTLCYLMFVLGKYPDVQEKVREEVKRAVDDSGPLDYETVTQKLKYLGQVINETMRIWPAGLTFTTRQAKE DFEYQGIKYKAGTCIMSPTLQIQRDERFFPDPMKFDPDRFSEENEDSFPKIAFQPFGIGPRNCLGMKLALIELAYTVARM TQHFRWELGESQKGEMPIDQYGMVSSPASGPWVLFHRL >&P450_Is224, 34549.m000043 MKYVGQVVNEALRIWPPALTFTTRQAKEDFEYKGIKYKAGTCIMSPTLQIHRDERFFPDPMKFDPDRFSEENESSVMKIA FQPFGLGPRNCVGMRLALFEIAYTVVKMTQHFRWELGDSQLASSISKELPITITKSASSLSSPSLCAYHHHCS >&P450_Is225, 34549.m000044 MMGHIAQMCDVFMDVLGEDADNGREVHMVSKFQGLTMDYLGRAAFGIDTSFQRDLNHPFLITAKEAAHGLMTGPVHMLAQ CTTSFGNLATPLLWLNWIFGSFPVRKFAEHAAKVIRLRKNNPELRRNDILQNLIDAEYEELPTTPKTVSEQTKITGTLGT DKIRRLRFEEVVMNTTLLFLAGFETTATALCYVTYALAKYPGVQERVRNEVNEALHGSGCLDYEAVTQKLKYLGQVVNEA LRLWPPILTFSTRQATEDFEYKGIKYRAGTCIMSPTLQIHRDARFFADPTKFDPDR FSAENDGSFPKIAYQPFGLGPRNC VGSMLALLEITYTVAMMTHRYRWELGQSQKGEMPLDQYAMVSIPGRGPWIVFHRI >&P450_Is226, 34549.m000045 MYLLAIFCTLIVVPVVILVRWRKKTFEYFKNIGIPGPEPNIFWGNLLEYHRNGRDNALKRWYDKYGKVFGFYNGDVPTLV VSDIDFLNYVFVENFKNFVDRGITMRSDQEHSFLGQAIVHAKEPQWRILRSITSKEFTPYKLRRMMPHLVEQGDIFMDVL DKLADEGRAGVNE >P450_Is118, VBpre_P006311 Same as P450_Is225 RHMGQNIQYLAFSCRVAFRRW FSAENDGSFPKIAYQPFGLGPRNCVGSMLALLEITYTVAMMTHRYRWELGQSQKGEMPLDQYAMVSIPGRGPWIVFHRI >&P450_Is161, VBpre_P009154 75% to P450_Is226 MMPYLVEQGDIFINDLGKLADERREESMLDAFQALSMDFICRAAFGIDTDFQHNIKNPFYVQAEGVIPGMMKGPFHAVAQ CTTTFGRLIKPLSWLNRILGSFTMEIFAREMKKVVRLRTQNHGMQRNDMLQNFLEAEVINKYPFNKIASMNAKNSEGKI >&P450_Is288, 35117.m000009 RQEDFLQLMMDAQDGSIATTVETVQSTEEKLFNLDSEIKTDTSFLGGVKGLFCLRSLTEDEAMAQCLLFFIGGQDTTSFV ISYTVYLLALHPEIQAKLREEADECFKQHGPDPSLDVVSKLKYLHGVVSESLRMFPPQVRIERSALNDYVLGDTGIKVPK GCVVVVPVYSMHHDPEYFPDPTTFDPNRFSDENIDSIRPYTYLPFGAGPRNCIGMRFALEAVKLSLLHSVHSVEFVPTKN TK >P450_Is023, VBpre_P001238 Same as P450_Is288 FFFFFACFLGWFLVSFGSLLFLRYAARYRNYWKDQNVIHEEFSLIFAAARRLIFKPFHQMDQDRYRKFGKLFGVYEGAQP VLFVADPELVKRVLVKDFPSLPNRRAISFNDSLLDNMMSIVPVEKWRRIRPAASPAFSTGKLRKMNFLIADCARKTAEHL KVAAEKEGELDIKQRPIPFFLFLLYPHNLFHSLAFPSFLFRALTASPFGFFFQKQTFPRTYTMILFPGVFKLFKLKVFNA DIFLYFKNVCLRIIESRKEKKS RQEDFLQLMMDAQDGSIATTVETVQSTEEKLFNLDSEIKTDTSFLGGVKALTEDEAMA QCLLFFIGGQDTTSFVISYTVYLLALHPEIQAKLREEADECFKQHGPDPSLDVVSKLKYLHGVVSESLRMFPPQVRIERS ALNDYVLGDTGIKVPKGCVVVVPVYSMHHDPEYFPDPTTFDPNRFVDENIDSIRPYTYLPFGAGPRNCIGMRFALEAVKL SLLHSVHSVEFVPTKNTK VPLEFVRGSAVLSAKHITIGIRKRTA >&P450_Is219, 23013.m000009 CFPELTFLWKCVFWFKRHFMKLPINKINELLMPIINIRRSQPLSVDQDFLQLLLNAEAEDDRATNTHTKKGDNDNTRYLE NKTSLRKTRLLTNVEIQCNVISFLVDGVETASTAMTFMAYLLAKHPDIQDKVRSEASATLEKDGEFNSGNITSLRYMDQV ISEALRVYPPITGFVTRTCEKDYDWNGLKIPAGMSIKIPVYQLHHDRNLWHEPEKFDPERFSDDNKGNIVPMAYQAYGNG PHNCIGMRFAQLELKLMLAKLLANYKLLLDEKRMKENPFELDSSSIFCYPRKGVWLKLQKISSVL >P450_Is031, VBpre_P010176 Same as P450_Is219 MMGVNLIATELINHLNFLVNGWESYLVE CFPELTFLWKCVFWFKRHFMKLPINKINELLMPIINIRRSQPLSVDQDFLQL LLNAEAEDDRATNTHTKKGDNDNTRYLENKTSLRKTRLLTNVEIQCNVISFLVDGVETASTAMTFMAYLLAKHPDIQDKV RSEASATLEKDGEFNSGNITSLRYMDQVISEALRVYPPITGFVTRTCEKDYDWNGLKIPAGMSIKIPVYQLHHDRNLWHE PEKFDPERFSDDNKGNIVPMAYQAYGNGPHNCIGMRFAQLELKLMLAKLLANYKLLLDEKRMKENPFELDSSSIFCYPRK GVWLKLQKISSVL >&P450_Is006, VBpre_P012112 40% to P450_Is219 TLSFCFFRVAKHQEIQENVREEVISVLAKHGALNYEAISELQYTSQVLNETLRVHGPVTAFTSRMTNQDYKYQDVLLRRG FSVIACSHLVHKDPNLWPEPDKFDPERFSPEQSSSRDPLCFQGYGMGPRICVGSKLAQLEMALVLAKVLLHFRLELGQRG ISEGRLETAGYSIMEAPRDGVWLKLHELEQPFSKCSG >&P450_Is285, 33104.m000013 AE WKKTRRVLNPIFTAAKIKMMSQIMTGCSEEMLGIVDRKFDGGEAVDMLQIAQGLSLDVISKCALAWKVNCQTNTTDPL LRAMHSVVDDAENTLIQYAIALPILRKIAEWIYPYASYYKITTKILDNVREVIEYRRSGQGSRTTDMLQLMLDAQAGKEA KATTSSKGDMLIEDRHLLSNSFLFLAAGFDTTALTLAFGAFLLAKYPEEQERVFNEIVSVFSEPDTELTYDGIQKLKRLD MLIAETMRLYPPVVLFVSRCCRQDTTIMGQFIPAGVNVLVPTWHVHHDPNLWPDPYRFDPERFADGRNTHHPAAYLPFGL GPRGCIGKRFALLEIKMAM >P450_Is016, VBpre_P008946 Same as P450_Is285 MAKSVLRALFLLPLTVHRSLKVFENWIQKYGKVFGYYQGEIPFIVLTDVDMIRDCFIKETNTFHDRPTLVLNVEPYISSL LGVEGKA WKKTRRVLNPIFTAAKIKMMSQIMTGCSEEMLGIVDRKFDGGEAVDMLQIAQGLSLDVISKCALAWKVNCQTN TTDPLLRAMHSVVDDAENTLIQYAIALPILRKIAEWIYPYASYYKITTKILDNVREVIEYRRSGQGSRTTDMLQLMLDAQ AGKEAKATTSSKGDMLIEDRHLLSNSFLFLAAGFDTTALTLAFGAFLLAKYPEEQERVFNEIVSVFSEPDTELTYDGIQK LKRLDMLIAETMRLYPPVVLFVSRCCRQDTTIMGQFIPAGVNVLVPTWHVHHDPNLWPDPYRFDPERFADGRNTHHPAAY LPFGLGPRGCIGKRFALLEIKMAM CKIIRKYTFIPCDGTPEDVELVVNNIMISPKGGLKVRLQRR >&P450_Is322, 18622.m000014 MAASALSTSLPPPPPCPTIVQIF RKVLLDLESVLVDGLVCFPPLRQAIEWVYPYSSYHDVTKQITDNLSKVIDLRRKKQG SRPTDMLQLMLNAQEDHENVTSADLGENTFSIKDRHLMANSFIFLVAGFETTATALAFVMHTLAKYSDEQDRVFRELTKV FPKKNQTLTYDGVQQLKRLDMVIREVLRLYPPVVLFVSRVCREDRSVMGQFLPAGVNVLVPTWHIHHNPDFWQDPNTFNP ERFSEGKSAHHPAAYLPFGMGPRMCIGERFALLELKLVTCHVLRRYRVTTSNRTHDLMKITVSSVVIRPKECIEVNLELR >P450_Is069, VBpre_P002809 Same as P450_Is322 KISAMVFPLWITVTSLILVVATGIFLSLLHRRRQHGFFRKYGIPGPEPDLLSGNYMQLKKDRIEVMEGWIKRYGKVFGFY LGERPYMVVTDLDVIKECFIKETNNFYNRPNIFLDFEPFRSSLIGLSGFEWKKVRSALNPSFSASKMKMMTHTMSQCVEE MLEVLREHADRGEAVNMLDVSQGLTLDVIAKCGLAWQVECQRNVTDPMLQAV RKVLLDLESVLVDGLVCFPPLRQAIEWV YPYSSYHDVTKQITDNLSKVIDLRRKKQGSRPTDMLQLMLNAQEDHENVTSADLGENTFSIKDRHLMANSFIFLVAGFET TATALAFVMHTLAKYSDEQDRVFRELTKVFPKKNQTLTYDGVQQLKRLDMVIREVLRLYPPVVLFVSRVCREDRSVMGQF LPAGVNVLVPTWHIHHNPDFWQDPNTFNPERFSEGKSAHHPAAYLPFGMGPRMCIGERFALLELKLVTCHVLRRYRVTTS NRTHDLMKITVSSVVIRPKECIEVNLELR >&P450_Is330, 34947.m000048 SYQGFVPTLVVGDPLLVRDICVKNFKSFTHKIKPNV MGNSMWDKVMLNTPDEEWKAARSIMSTALTTSRLKAMITEIISA ADKFCTRLLLEGENKSAVEVSKMFEGCAINAMAALVYSVDLDPHETPDHPLVKCGNEFSASLNGWKMILLSSMPTVYKLL PMKFSSNKGTEYFKEFTRHMAQQRCASNQRFDDVLQLCLDDLAHGRSHDNFKISEPTIEDLAAQCMQFLVAGSDIVALTL MWTAYSLASHPECQEKVLREIDIAVKQNGVTYEALKEMPYLEAVINEALRMYTPDSFLIRRCTQEISVAGIEVRPGMCIE IPIEGIHHDPEFFPEPECFKPERFLPENKDALVPYTFLAFGAGPRNCVAQRMGIIQTKATLACLLRNIKFQRCTETPVPL KLQTASWLLQSLKPVKLGCISRIQ >P450_Is034, VBpre_P005958 Same as P450_Is330 MGNSMWDKVMLNTPDEEWKAARSIMSTALTTSRLKAMITEIISAADKFCTRLLLEGENKSAVEVSKMFEGCAINAMAALV YSVDLDPHETPDHPLVKCGNEFSASLNGWKMILLSSMPTVYKLLPMKFSSNKGTEYFKEFTRHMAQQRCASNQRFDDVLQ LCLDDLAHGRSHDNFKISEPTIEDLAAQCMQFLVAGSDIVALTLMWTAYSLASHPECQEKVLREIDIAVKQNGVTYEALK EMPYLEAVINEALRMYTPDSFLIRRCTQEISVAGIEVRPGMCIEIPIEGIHHDPEFFPEPECFKPERFLPENKDALVPYT FLAFGAGPRNCVAQRMGIIQTKATLACLLRNIKFQRCTETPVPLKLQTASWLLQSLKPVKLGCISRIQ >&P450_Is194, VBpre_P001089 49% to P450_Is330 MLFAMPKVLKILKRIVEFPSRKSTDYMIQFTRFLVDQRIEEKKKFDDVLQILLEATLEAKDKDSVEITDAEIDEIASQCM LCIVAGTDAVKHTLTCAVYNLVMHPQYQERLIQEVDDTLKETDVTYDALKAMPFLEAVIYETLRMYTPDSFLTRVCTKET VVSGIRLKPGMGIEFPLRGVHYDSEFFPDPYLFNPERFLPENKPNMIPYTFLAFGEGPRNCVGTRMATVVIKAMLATIYR VMKFERCSDTPDQLKFVPRSLLLEFQEPIKVQIIPRSTKKAQRAAANDKPQ >&P450_Is035, VBpre_P005959 75% to P450_Is330 C-term MSIEIPIHGMHHDPEFFPEPDCFKPERFLPENKHALVPYTYQAFGVGPRNCVGQRMGMLQTKATLACLLRKIKFQRCSET QVPFKLQARSLILQPTETVKLRCVPRA >&P450_Is192, VBpre_P001087 42% to P450_Is330 MNAMTVVVVAFLALVGFFVWKLQQIFTFWSDKGVPYLTLWQYLRVVYDMYTKPLHEVIRKNYERYGRLYGSYQGIVPTLV VGDPDILADVFVKNFKSFSDRTEAQTIGTDIWKKSILNLSGEEWKHARGILSPAFTANQLRKAVVKIHKISERMTTRLAE YAKDKKPVAINE >&P450_Is193, VBpre_P001088 74% to P450_Is330 MHLFVQRSTHDIDESTCEACLLICRWTIRTFTYWNDKGVPHLSFMEYMRTAYDIFTKPLYEVVQRNYERHGRVYGTYQGF VPTLVVGDPNLLRDICVRDFKSFADRSVSLN >&P450_Is276, 20903.m000027 LTEDEAMAQCIVFFVAGQDTTSSVISQTLYLLALHPEIQVKLREEVDDCFERHGPEPSLDVVSKLKYLHGVVSESMRMFP PGPRLERSALNDYVLGETGITVPKGCLVALPVYSMHHDPDNFPNPATFDPNRFSDENMGSIRPYTYLPFGAGPRNCIGMR FALQAVKLSLLHSVHNVQFVRTENTQVSI TSRSF >P450_Is126, VBpre_P006894 Same as P450_Is276 TTVG LTEDEAMAQCIVFFVAGQDTTSSVISQTLYLLALHPEIQVKLREEVDDCFERHGPEPSLDVVSKLKYLHGVVSESM RMFPPGPRLERSALNDYVLGETGITVPKGCLVALPVYSMHHDPDNFPNPATFDPNRPVDENMGSIRPYTYLPFGAGPRNC IGMRFALQAVKLSLLHSVHNVQFVRTENTQVSI >&P450_Is038, VBpre_P007210 58% to P450_Is276 IKFGDPVLDNMMTAASLDRWRVIRAVASPAFSASRLSSIIADCARITAEHLRTCEGDLEVKTFYANFGLDVIARCSFGIK LKPHSDVTNKFVIEAKRAFSRNMTLPLIAIYLFPGLIQWFNIKLLNFDIIRCFKDLAGKAIRERDKGGHKSEDYLKLLMD AREERHDTNGYPNRRETPERSGEVLHRVKRTMATFFSALSEVEVLAQCVVMFLGGQDSISSLIAHTVYLLALHPDKQTKL RGEVDRCFSSHGEEISPKVISKLDYLHGVVSEALRLFPPATRIDRSTTEDYALGDTGITLPKGCTITVPIYAMHRDPLNF IDPDSFIPERFSEDNASTISPYTYLPFGAGPKGCLGTHLALLAVKLCLLYSLRDVEFFRTSKTKVPLKFYNGFGLLHSAP FSVGIKKRSTAPMSTSTHNAN >&P450_Is267, 26818.m000011 MYPRINDSIGATVTFLKEAAEKDTEVDIRTLFSNYALDAIARCAFGTKMESHLKEVDDFAAKNKSFFAAPQALSGVIS P LTKSEALAQCIMFFLAGRDTSATLLAHAIYMLALHPEAQAKLRKEADECFEKHGEELTMDVVAKLKYVRGVVSETLRMLPP ATRLERLAAEDYVLGDTGIRVPKGCIIAIPIYSMHHDPE YFPDPFTFKPER FIGENIESIRPYTYLPFGAGPRNCIGDRFALEAIKIALLHVVRSVEFY >P450_Is106, VBpre_P008230 Same as P450_Is267 VFEGSQPVLVVADPELVKLVLVKDFTSLPDRRPIPFVQPLLEEMMAFVTLKKWRKLRPSASPAFASGKLRK MYPRINDSIGATVTFLKEAAEKDTEVDIRTLFSNYALDAIARCAFGTKMESHLKEVDDFAAKNKSFFAAPQALSGVIS LLLPSLAKLLRLDALKSDRLPYFMALSESIIRERKHQENRQ EDFLQLMMDVQEETSSSGADSQTDDRLFNPESGSKAFSMGRRRA LTKSEALAQCIMFFLAGRDTSATLLAHAIYMLALHPEAQAKLRKEADECFEKHGEELTMD VVAKLKYVRGVVSETLRMLPPATRLERLAAEDYVLGDTGIRVPKGCIIAIPIYSMHHDPE FIGENIESIRPYTYLPFGAGPRNCIGDRFALEAIKIALLHVVRSVEFY RSQNTR >&P450_Is002, VBpre_P000827 91% to P450_Is267 SFCRIERLAAEDYVLGDTGIKVRKGCLIAIPVYSMHHDPEYFPDPFSFKPERFIGENIESIRPYTYLPFGAGPRNCIGNR FALEAVKIALLHVVRSVEFYRTQNTAVRKNIFL >&P450_Is056, VBpre_P003764 92% to P450_Is267 LSLSFCRLERLAAEDYVLGDTGIKVRKGCLIAIPVYSMHQDPEYFPDPFTFKPERFIGENIESIRPYTYLPFGAGPRNCI GNRFALEAIKIALLHGVRSVEFYRTQTRGA >&IS039, VBpre_P007066 MLLVSVTSNAQNTQKKNAVYVILQTYALMFQGNLNIIEEWSSIYGDIFGYFHGFRPILVIRDPELIKQIFIRNFDSFPKR QLIQEASGVVPVNTVKLSRISGDKWRLIRALISTAFKSNKLKQAFPMIEECTDEFLRIMEKDKAAQERGGIDISPAFCRL SLEILLRFTMGARLNVQAASKETEAILNAGRNAARRFPLGLLMVCNLIPTWDIVKTVMVFLQGCLREAPTEMFNKYLFEL VRQRRERGWTETEDLFQLLFNAEEKCGPDRKPDGTTQSTEKGHSGNSDTTRTERTITPFETAANVEFFVIAG >&P450_Is315, 21960.m000014 DEWKKMRTLLNPAFSAAKMRLMMQTINKSADVFVDILTESSQKGAVLEMYKVAQGLSLDVIAKCALAWQVDCQRNPDDPL LKELQNIFRNTSNVGARISFWFPALKHVIEILHKKWQFMVTQENIIANLRNVISLRRRGQAPSVPDLLQLMLNCQSDASN AKDHTDQKNLLLEDRMLIANCFIFILGGLETTSLALAYTLFLLAKHPEEQDRLFQELTDMFPGNQELSSDDLRKLKRLDI VFKESLRLYPPTVAFVSRTCRRDITVMGQFIPSGTSVTVPVWHLHHDADYWPDPFKFDPERFSEGQERHPPEAYAPFGLG PRACIGSRLAMLELKATLVKVVRRFKILLCEETQDPPKIRIPLSLTLPENGIRLKLERRVP >P450_Is046, VBpre_P008473 same as P450_Is315 IKKKTLSEYQGSTHTDSSAGSKLQTIMLAG DEWKKMRTLLNPAFSAAKMRLMMQTINKSADVFVDILTESSQKGAVLEMY KVAQGLSLDVIAKCALAWQVDCQRNPDDPLLKELQNIFRNTSNVGARISFWFPALKHVIEILHKKWQFMVTQENIIANLR NVISLRRRGQAPSVPDLLQLMLNCQSDASNAKDHTDQKNLLLEDRMLIANCFIFILGGLETTSLALAYTLFLLAKHPEEQ DRLFQELTDMFPGNQELSSDDLRKLKRLDIVFKESLRLYPPTVAFVSRTCRRDITVMGQFIPSGTSVTVPVWHLHHDADY WPDPFKFDPERFSEGQERHPPEAYAPFGLGPRACIGSRLAMLELKATLVKVVRRFKILLCEETQDPPKIRIPLSLTLPEN GIRLKLERRVP >&P450_Is036, VBpre_P006026 73% to P450_Is315 C-term DRAVLANCFNLMFAGFDMTSLALAYTMFLLPKHPEEQERLLQELTDAYPNNQELSSDDLQNLKRLDMAKESLRMYPPNVG FISRACQRDITVMGQFIPSGTTVTVPVWQHHHDADYWPDPFKFDPERFCEGKGHIPEAFVPFGLGPRACIGSRFATLELK ATLCKVVRGFKIVLCEEAQDLPNMYVPNLVVLPENGIRLKLERRDL >&P450_Is297, 35255.m000038 QRGVVGCKMNFLGVPDWVILVVTALVLLYLYAARYRNYWKEQNVVHENFSLIFAAGKRMLFKPFHR MDQDRYLQFGKLFG VYEGGNPMLFVGDPELVKLVLVKDFPSLPNRRMINFFDPLLDNMMSMVPAEKWRRIRPAASPAFSTGKLRK MNNLIADCA RKTAQHLEETAEKEGELDLKQ FYGNYALDVIAGCAFGTRLDSHTEETNEFVAKARQAFSGKITPRLVFFFLLPGLAKLLR MKSFDSDSFLYFKNLSLQIIENRKKSQS RQDDFLQLMMDARDGSIAATDEISTSTDEKLFNLDSEMKTDTSFVGGVKA LTEDEAMAQCVLFFLAGQDTTSSVISFTLYLLAIHPEIQAKLREEVDDCFKKH GPEPS LDVVSKLRYLHGVVSESLR MFPPATRLERSALSDYVLGDTGIKVPKGCVVAVPVYSMHYDPDNFPDPTTFDPE >P450_Is190 VBpre_P006457 Same as P450_Is297 MDQDRYLQFGKLFGVYEGGNPMLFVGDPELVKLVLVKDFPSLPNRRMINFFDPLLDNMMSMVPAEKWRRIRPAASPAFST GKLRK VCAVTQYTLYKINTISKKMNDLLLGVKSKNRQTTLWPSVYYFCSLLTVNNFQVKDCDFK FYGNYALDVIAGCAFG TRLDSHTEETNEFVAKARQAFSGKITPRLVFFFLLPGLAKLLRMKSFDSDSFLYFKNLSLQIIENRKKSQS VSISSSFT LTEDEAMAQCVLFFLAGQDTTSSVISFTLYLLAIHPEIQAKLREEVDDCFKKH VRRLMHLQNKD LDVVSKLRYLHGVVSES LRMFPPATRLERSALSDYVLGDTGIKVPKGCVVAVPVYSMHYDPDNFPDPTTFDPE SMSKLLLYSFAIFGPRNCIGMRFA LEAVKLSILHSLHSVEFVRTKNTKVS >&P450_Is166, VBpre_P003853 75% to P450_Is297 C-term MFPPAPRLERSPMEDYVLGETGIKVPKDCVIAIPVYSMHHDPEFFPDPHTFNPE RFIGENASSIRPYTYLPFGAGPRNCI GMRFALQTVKTCILHAVHNIEFIRTPRTKVPLEFHPGFGILNPKDLTVGLRLRKL >&P450_Is167, VBpre_P003854 41% to P450_Is297 MMTVVPPKEWKKIRSATTPAFTTGKLRKMHDLMEQSAQHLSCKLKNAAEKELDVDMKRFYGHFTLDVTASCAFGSKLGND SEDTSNFVSSAKNAFFAKITFFVAIQVFFQRFMKTLRRNIFNMDAFEFYKDATISIIQERKKGKQVHDDFLQMMLNAQDE AASTASEITESSNQEIF >&P450_Is001, VBpre_P000543 60% to P450_Is297 MNALIEDCAKVTAEHLKKAAKNNEDVDIKQFYGHYSLDVIARCAFGTRLDSHTDVTNEFVTRARKAFSGVITLPMILLVL FPALFNWLKIKPINSDTFVYFKNVCQNIIKNRQQESNRQEDFLQLMMDAQQNGIATAAAENVQETNTQIFNLDSEVKPDS SFSAKALTEDEAMAQCVLFFLAGQETTSSVIAHAMYMLALNPKIQAKLREERMSVLLHM >&P450_Is284, 26269.m000016 38% to CYP3A7 human EEWKRIRATLNPIFTSAKMKMVTQIIQNCADEMVEVLADLVQKGEIVDMATVTRGFSMDVITKSALAWQ VDCQKNPTDPL LMGVQKVFEDVDNAVIVNAIRFPVLRKILEWLYPYASYYKIINKITENVLNVVKLRRSGQSPRTTDMLQLMLDAQTSGEE SSVGSGSNATIFEDRHLLSNCF LFLIAGFDTTASSLAFIMHVLAKYPEEQERVFNEISKAFPDGAELTYDGVQHLKRLDM VVCETLRLYPPVVLFVSRHCTQDTTVSGQFFPAGVNVLVPTWHVHHDPEFWPEPLKFDPERFSEGEKVQSAYFPFGLGPR VCIGKRFALLEVKLATCNIIRRYRVSKCEQTQDPLRFVVPSVVLNPENGIRLRLQKR >P450_Is182, VBpre_P005167 Same as P450_Is284 VDCQKNPTDPLLMGVQKVFEDVDNAVIVNAIRFPVLRKILEWLYPYASYYKIINKITENVLNVVKLRRSGQSPRTTDMLQ LMLDAQTSGEESSVGSGSNATIFEDRHLLSNCFLFLIAGFDTTASSLAFIMHVLAKYPEEQERVFNEISKAFPDGAELTY DGVQHLKRLDMVVCETLRLYPPVVLFVSRHCTQDTTVSGQFFPAGVNVLVPTWHVHHDPEFWPEPLKFDPERFSEGEKVQ SAYFPFGLGPRVCIGKRFALLEVKLATCNIIRRYRVSKCEQTQDPLRFVVPSVVLNPENGIRLRLQKR >&P450_Is143, VBpre_P003012 66% to P450_Is284 MRIEDRHILASSFSFLVAGFDTTASALAFIIHLLAKYPEEQDRIFSEMQQTFSEEAELTYDGVQQLKRLDMVISETLRLY PPVVFFISRLCRATTTLMGHLIPAGVNVVVPTWHIHHDPELWHEPFKFLPERFAEGEKHHPAAYLPFGLGPRQCIGRRFA LLELKFAVCRIVGKYKIYQCERTQDPLKLVVPSVNINPEQGVYVRLKER >&P450_Is174, VBpre_P004812 58% to P450_Is284 LITEKHLLANSFVFLAGGFETTATSLAFLLYELAKNQEEQEKVYKELKRIQRLKEELAYEDIQELKRLDMVISECLRMYP PLVLFTTRVCTQDITLMGEFFPAGVNVLVPTWNIHHDPELWPEPSQFNPERFGEGEAKHLHHPAAYLPFGMGPRECIGRR FALLELKIAVCKILAKYRIVPCIETEDPVKLVVPSVVLNPAQGIITQV >&P450_Is123, VBpre_P001957 58% to P450_Is284 VFLAGGFETTATSLAFLLYELAKNQEEQEKVYKELKRIQRLKEELAYEDIQELKRLDMVISECLRMYPPLVLFTTRVCTQ DITLMGEFFPARVNVLVPTWNIHHDPELWPEPSQFNPERFGEGEAKHLHHPAAYLPFGLGPRECIGRRFALLELKIAVCK ILAKYRIVPCSETEDPVKLVVPSVVMNPAQGIKLRFKYR >&P450_Is203, 17600.m000007 GPEPTLDVVSKLDYLNCVISESLRLYPPAIRLERSPVEDYVMTDTGIKLPKNCVIVIPIYAMHYDPSNFEDPYKFDPERY PTTCSHFTLGNHMF >P450_Is137, VBpre_P002111 same as P450_Is203 91% to P450_Is197 MDAQKEALSDGSDPGDAENDVYSLGLDEKSSVAIQRKTLTEMEAMAQCVIFLLAGQDTTSWVIAYTVYLLALHPDVQEKL RREVDECFEQY GPEPTLDVVSKLDYLNCVISESLRLYPPAVRLERSPVEDYVMTDTGIKLPKNCVIVIPIYAMHYDPSNF EDPYKFDPER FSEENRGCIRPYSYLPFGAGPRNCVGMRFALQTIKLCLLHAIHSVQFVRTPRTKVPLEFSRNLGLLTAKE IIVGVKPR >&P450_Is197, 17917.m000019 GPEPTLDVVSKLEYLNCVISESMRLYPPVNRLERSPVEDYVMTDTGIKLPKNHVIAIPVYAMHHDPSNFEDPYKFDPERF SEENRGCIRPYSYLPFGAGPRNCVGMRFALQTIKLCLLHAIHSVEFVRTPRTKVPLEFSRKFGLLAAKEIVVGVKPR >P450_Is196, VBpre_P007727 same as P450_Is197 FIFQ GPEPTLDVVSKLEYLNCVISESMRLYPPVNRLERSPVEDYVMTDTGIKLPKNHVIAIPVYAMHHDPSNFEDPYKFDPERF SEENRGCIRPYSYLPFGAGPRNCVGMRFALQTIKLCLLHAIHSVEFVRTPRTKVPLEFSRKFGLLAAKEIVVGVKPR >&P450_Is032, VBpre_P010192 53% to P450_Is203 YASRYRNYWKSQGVPYEKLSLFFGLTLQRYIKPFHLVDQELYRKHGRLFGVFEDGRPALYVSDPDLLKLVLVANYEDSER KTGVSCDDSLFDNMVAIAPSEKWRRIRAAITPLFTASKLRKMHNLVQELVIVPTEALINAAREGADVDPTRLYFPTASNV LSRCTLGKETDCGNDASIDIIHALYVPISFSLIGMYSISVSVRTFMKKVRSKFIRNKAFYFYKELCLNIVKKKQLDTTVS YHFTLNVGAMYCIVDIALSKHAMNLNFQKALDILKPPFNIKEDSASHKEKSITPQYILFHVAGVEAISGIAALVSYYLAV HPDVQAKLRDEADDCFAKH GRFPSYDVVSKLEYLDAVVLETLRICPPFTRLERTFNKDYVIGNTDIKVPKDCVITVPIYA MHHDSDFYPNPESFMPERF LEGNASEINPYTYFPFGYGPRNCVAQTFGLQVIKTILLHAVHEIQFVKTQRTKV >&P450_Is329, 33952.m000042 MMDHIAEGGDVFMGVLGEIADQGKEINMLKPFQGLTMDYIGRAAFGIDTSFQKDLNNPFLIAAQRTLREIMIGPFHMLAH WLSSSPNGETMAYCKVCKTELRPHIQDLKLHKSRLKHQNNVLLLSKPAAERMDSFVTARPRDTDPVIMYAKEIKAAELRL AAHVAVHGSFFAADYLAPLQAPYSEVYFQFTSFSKCATVGFDTSATALSFITYALGKYPDVQEKVRQEVNEVLNEGARED FEYQGIKYKAGTCIMSPVAVIHMDERFFPDPTKFDPDRYY >&P450_Is242, 25404.m000016 WRQKTFSYFKDIGIPGPKPNLLWGNLWEYHEKDLYQAVKKWCKQYGDIFGFYNGDVPMLVVRDLEFLKYVFVKNFSNFTD RGVTIRTDE MHPVVGRGLIHVKGSEWKNMRACITSGFSALKLKLMMDHFAKVGDVFMDVLGEIADQGKEVNMLEPFQGLT MDYIGRAAFGIDNSFQRDLKNPFLITAQRAIREIMTGPFHVLAQCTTSFGVLAAPIFWLSRIFGTFSYKDFGEETAKVIE LRKKHPELRRNDMLQNLIDAEYEELASTRASSGVSKTRALSSEEVIMNTTILFLGGFETSATALSFITYALGKHPDVQER VRQEVKEALNEG GSLDYETVTKRLKYVTQVIDEAMRIWPPGLT FTTRQAKEDFEYQGIKYKAGTCIMSPVFVIHMDERFFPDPTKFDPD >P450_Is111, VBpre_P006290 Same as P450_Is242 MHPVVGRGLIHVKGSEWKNMRACITSGFSALKLKLMMDHFAKVGDVFMDVLGEIADQGKEVNMLEPFQGLTMDYIGRAAF GIDNSFQRDLKNPFLITAQRAIREIMTGPFHVLAQCTTSFGVLAAPIFWLSRIFGTFSYKDFGEETAKVIELRKKHPELR RNDMLQNLIDAEYEELASTRASSGVSKTRALSSEEVIMNTTILFLGGFETSATALSFITYALGKHPDVQERVRQEVKEAL NEG VSFI >P450_Is112, VBpre_P006291 Same as P450_Is242 VSARACLFRFGTWANVIFIHR FTTRQAKEDFEYQGIKYKAGTCIMSPVFVIHMDERFFPDPTKFDPD RFSEGERRSYPEVCFP >&P450_Is221, 31822.m000008 cyan region does not match ESTs FETSATALSFITYALGKHPDVQEKVRQEVKEALNEGVSFINTEFTKKLKYVTQVIDEAMRIWPPALT >EW850156 same as P450_Is221 92% to P450_Is242 SFGVLAAPNFRLSQIFGSFSHQDFGEETAKVIELRKKHPELRRNDILQNLIDAEYEELAS TQTSSGVSKTRALSSKEVIMNTNILFLGGFETSATALSFITYALGKHPDVQEKVRQEVKE ALNEGGSLDYETVTKKLKYVTQVIDEAMRIWPPALTFTTRQAKEDFEYQGIKYKAGTSIM SPPFVIHMDERFFPDPTKFDPDRFSEENEGRIPKLAFQPFGMGPRNCVGTRLAYVELAYT VARMTQHFYWELGESQKGEMPLGTVRHGIDAGKKDLG >&P450_Is067, VBpre_P001528 60% to P450_Is242 FISDCTTSFGPLAAPILWLSRIFGNFSFKTFGEQTAKVIEIRKKHPELRRNDLLQNLIDAEYEDLAPTQTSSGEATSGII MNSTVLFVGGFDTSATALSFITYALGKYPDVQEKVRQEVNEVLNEGVSLIYSECVCALVFYENIVALDYRVRPLYVQLRY RAGTSSMHYNFLCTLSMFSLRHLTDCTLGHRAVSYIRVLSLSAFSEENEGSIPKLAFQPFGMGPRNCLGLRLAYLDLAYT VARMAQNFRWELGESQKAKMPLGQYGMVATPGRGPWIVFHRL >P450_Is171, VBpre_P004272 Same as P450_Is299 MYEAVRKHYKRHGRFYGSYQGLAPSLYVAEPEVLADVFVKKFKSFADRTIGQKLGNSLRQKSIFNLSGDEWKHARYILSP AFTGNKLKAVXRIVKVTERLTARLIEHAKNGTPAAANE LLHSCARDTTAAVVFSFDMDSHVDKKHPLMVCFEKLFAEVVPSWKVLLL FTMPTIFRHLRPKIEAKGDTDDLIHFVGLMADDRRSKQKREDDILQMFLDSGYVDSNGNVVPAVKPPPDGEKP LTIVDITAQCRLFFVAGTDTVMAAMMALAYLLALNPECQEKAIREIDAAVE >&P450_Is299, 35776.m000023 MPR LLHSCARDTTAAVVFSFDMDSHVDKKHPLMVCFEKLFAEVVPSWKVLLL S LTIVDITAQCRLFFVAGTDTVMAAMMALAYLLALNPECQEKLINEIDAAV KKDGVTYESIQSMVYLEACAKEAMRMYPAAMFLMRTCTEETTLAGINFKPGMNVDIP IAGIHYDPEFYPDPESFKPERFLPENKDSHTPYTYLPFGSGPRNCVGIRMGYLIVKVVFACLLQHVKFGTCPETMIPLKL KPRCLLPLPRRSVMLQVYSRT >&P450_Is300, 35776.m000024 MDSHVDKKHPLMVCFEKLFAEVVPSWKVLLLSLTIVDITAQCRLFFVAGTDTVMAAMMALAYLLALNPECQEKAIREIDA AVEKDGVTYESIQSMVYLEACAKEAMRMYPAAML >P450_Is172, VBpre_P004273 Same as P450_Is299 MAAMMALAYLLALNPECQEKLINEIDAAVKKDGVTYESIQSMVYLEACAKEAMRMYPAAMFLMRTCTEETTLAGINFKPG MNVDIPIAGIHYDPEFYPDPESFKPERFLPENKDSHTPYTYLPFGSGPRNCVGIRMGYLIVKVVFACLLQHVKFGTCPET MIPLKLKPRCLLPLPRRSVMLQVYSRT >&P450_Is187, VBpre_P012044 85% to P450_Is299 LTIVDIAAQCRLFFAAGTDTAMAAMMAMAHLLALHPECQEKLISEIDATVEKDGVTYESIQSMHYLHACVKETMRLYPGA MFLMRTCTQETTLAGINFKPGMNVDIPVVGIHYDPEFYPDPESFKPERFLPENKDSHTPYTFLPFGSGPRSCVGMRLGYL TVKVVMVCLLQHVKFGTCPETMV >&P450_Is306, 35326.m000027 MADLIWKVLASPLLLLVPSILLFWAFRRRRAHGLFRRNGIPGPEPELFWGNWKQLKKNRIQVLQQWIEEYGQVFGFFMAE KPWMVVTDLDLVRQIFVTEANTFTDRPQYVIDVEPFTSALPFLPGDEWKKVRPVLNTSLTAGKMNLLSGIVSECAREFLE VLRKHHERKDVVNFVEAAEGYALDVITRVGLTWNTKCQQKSDDPLLLGLRWIFEDLDKTAVENTLAQPGIRTILRHLYPL TSFSKVLSRIAKNVRDTAHKRRQGQAPREKDILQAMLDAQDGVEDKECDS CLPLEHGAWRKNGIHKNGLLIED RHLTSNS IMVLIANFETTSATIGFTLHLLATHPEEQDKLFLEIDAMLPQTSETSLNNLQNMTRLDMVVKESLRLYPPIPILVTRVCP RDTTVMKQFIPAGTMVVAPAWHIHRSPQFWNNPSRFLPDRFAQDQPERHPFAYFPFGLGPRSCFGKRLAVLQVKTAIVEI LRNYRVLPCGETVDPIRVTVPNVLLRPVGGIKLRLASRR >P450_Is064, VBpre_P011804 Same as P450_Is306 MADLIWKVLASPLLLLVPSILLFWAFRRRRAHGLFRRNGIPGPEPELFWGNWKQLKKNRIQVLQQWIEEYGQVFGFFMAE KPWMVVTDLDLVRQIFVTEANTFTDRPQYVIDVEPFTSALPFLPGDEWKKVRPVLNTSLTAGKMNLLSGIVSECAREFLE VLRKHHERKDVVNFVEAAEGYALDVITRVGLTWNVSACQQKSDDPLLLGLRWIFEDLDKTAVENTLAQPGIRTILRHLYP LTSFSKVLSRIAKNVRDTAHKRRQGQAPREKDILQAMLDAQDGVEDKECDS Y RHLTSNSIMVLIANFETTSATIGFTLHL LATHPEEQDKLFLEIDAMLPQTSETSLNNLQNMTRLDMVVKESLRLYPPIPILVTRVCPRDTTVMKQFIPAGTMVVAPAW HIHRSPQFWNNPSRFLPDRFAQDQPERHPFAYFPFGLGPRSCFGKRLAVLQVKTAIVEILRNYRVLPCGETVDPIRVTVP NVLLRPVGGIKLRLASRR >&P450_Is159, VBpre_P007985 57% to P450_Is306 VMGQFIPAGTTLIAPAWHIHRNPEYWPEPSRFPPERFAEGHPERHPMAYFPFGIGPRTCIGRRLALIELKMSICKILRDF KLVPCEESQYPVPLVVPNLTLRPGVGLRVRLEMR >&P450_Is070, VBpre_P008383 58% to P450_Is306 TLRLYPPVPLLVARTCLLDKTVMGQFIPAGTTLIAPAWHIHRNPEYWPEPSRFLPERFAEGHPERHPMAYFPFGIGPRTC IGRRLALIELKMSICKILRDFKLVPCEESQYPVPLVVPNLTLRPGVGLRVRLEMRRKCKD >&P450_Is050, VBpre_P005615 64% to P450_Is306 LIEDRHVIANSIVLLIAGFETTAMVIGFTLYLLATYPEEQEKVHSEIDTVLPYDDEISLDSIQNLKRLDMVINETLRLYP VLPIMIARLCPRDMTVRDQFIPAGTSVFAPAWHIHRDPESWPEPSRFLPDRFAEEHPERHSLAFIPFGLVPRYCFGKRLA LLEVKMALCAILRKYRVIPSEETVNPISVTVPSVTLRPVGDIKLKFENKAER >&P450_Is145, VBpre_P003017 45% to P450_Is306 MRVKAVAKFSLCSSFQFGMETALWMIWIFASTLLATCGVIWVLKRRYRHGFFKRLGIPGPEPELLFGNWQQLRKDRINVM EDWIQKYGKTFGYFKGAVPFFIISDVEMIKQCVVKEAQTFYDRPEPSISIQPYIQTLLFLK >&P450_Is251, 28718.m000008 NLSKYLCWMLYLLAKHQDVQKKVKAEVQKILVTEGAINYGTVTKMQYLEQALKEGLRMHSSPS GFVTRLAEKDIDTGSVVIPKGVSILIPTYILHKDSELWEDPERFDPE RFAPGNNKPVEVDSIAFQPFGAGPRNCFAMMFSKVILMLLLAKVLSEYRL VLNDDHHKVSA >P450_Is148, VBpre_P013768 Same as P450_Is251 MMTMLSSNHPVRKLHMFNATGRKWKTIRSVCTRAYNSVYIKKMSHLLELCTDEFLEALEATADKGEQFDTVSMCRAFAAS AMLRTAFSFKMDEQDKTGRDISKCVDKLTLRNIALFDGGLLHWLSNCFPEFTRLIQLALRIAEYIKPPGMCEVLDAIAPI IYTRKLNQSEIRSTDLLQFMVDAAAPNSGCPGPSDPLTTSSRDKTTGDSMEGNAELPSEWLLSDAEILSNASLVLSV GFVTRLAEKDIDTGSVVIPKGVSILIPTYILHKDSELWEDPERFDPE >&P450_Is158, VBpre_P013243 47% to P450_Is251 MDNWRLIFGVEDALWRRRASIHLEHLDYVFRHNPPKHKRFSATRGERRVQVGGESGNGPIAAFKDWTDKYGDIVGFYNGA VPTLLVRNLDLIKEIQISKFKSCNPRGMSTVIEKSADSYLKVLESVVAPGKAIDVFPIHRLMAADVILRTMFSFNVDGQG RSLKCLQDAVIKPVANIRVFKDGWLHWLSSTSVSRFVEEDIEWKGLTIPKGISVAIPSHMLHHDLDLWQEPDVFDPDRFS PERKASVNYTAFQPFGAGPRKCFAEEFSKRAVTFLVAKTLEHYRVDLSTDHHKRGVSETHCPRGQGFAVEHASFASLRLT ADDHAYFRITASGISLSRDQFCVLPTAP >&P450_Is272, 34530.m000468 MWVLVCTALTAVTFTLFYLRRRQRFSLFKNTGIPGPAPSLFTGNISELIEKGAVRLFEEWVNKYGDIVGFYNGVTPMLIV KDLDLIMKIQIKDFGNFHGRGVTAKILREHQKSKLKLIYVDGDRWKEMRSLLTPAFTSSNMKKISSVMDTCTDEFMEVVD SLSDQDKAFEMWRVYRKLSMDVIVRSAFGVESTFRKIRALPV >P450_Is183, VBpre_P011188 Same as P450_Is272 MWVLVCTALTAVTFTLFYLRRRQRFSLFKNTGIPGPAPSLFTGNISELIEKGAVRLFEEWVNKYGDIVGFYNGVTPMLIV KDLDLIMKIQIKDFGNFHGRGVTAKILREHQKSKLKLIYVDGDRWKEMRSLLTPAFTSSNMKKISSVMDTCTDEFMEVVD SLSDQDKAFEMWRVYRKLSMDVIVRSAFGVESTFRKIRALPV >&P450_Is080, VBpre_P009104 54% to P450_Is272 MAAPVWVAFLAVLVVWYFFWRKRKLAVFKTLGIPGPAPSFFTGNMSEILKKGSVVTFSEWIKQYGDLVGFFNGGTPVLIV KNVDLLKKIQIKDFGNFTCRGVVSAVSKNHNLSRRALTNVPGERWKEVRSLLKPAFKASNMKQVKPF >&P450_Is331, 18819.m000045 FTTRRALEDYAYGDLVIRKGTSVLASTYQIHHDPMLWPEPDKFDPERF >P450_Is022, VBpre_P001233 same as P450_Is331 42% to P450_Is225 TLFISSRTLLYSSTHAQMMPAMHHAVDCFLNILDGYAERGQELDMSAVSAQLTFDVIGKTAFGIDTKVQDSMDNPLYRAA IDAHPYLMSGAIYNLARKSKALSSSEEPIPWLVFSITPSKMEKMSQQLLTLVTLRRSLFQIKKVDLLQNLLEAVLPSGGE SEVEQNGKTKNNGLYHIVSGVHRYDTTRLTLSYWAFLMGKHPDVQEKMRTEVMQAAQNGPLAYEDITGLVYTQQVLNETM RLHPAVVAFTTRRALEDYAYGDLVIRKGTSVLASTYQIHHDPMLWPEPDKFDPERFSPENKASIPANAFLPFGVGPKHCL GQRLAQLELAFITAMLLRRFRITLGPSQKPDVEYVTYAMLAAPKNGVWIKLQKLEA >&P450_Is275, 20832.m000013 LRRSGISPDVPDMLQL MLDAQTEKGSSADDHDENEPLIEDRLLIANCFIFLLGGFDTTAVALAYIMHNLAKYPEEQDNIL REITEAFPDKKELGYDELHRLKRLEMVISESLRLYPVIVTFVSRNCQQDITVMGQFIPAGANVTLPVWHLHHSAEHWPDP LKFDPERFSEDKGKPHVGAYLPFGLGPRACIGKRFAMLELKATVCKVLRSFRVVQCEETQDPLKVVVPNATAYPKDGVKL KLELRNP >P450_Is173, VBpre_P004745 Same as P450_Is275 MLDAQTEKGSSADDHDENEPLIEDRLLIANCFIFLLGGFDTTAVALAYIMHNLAKYPEEQDNILREITEAFPDKKELGYD ELHRLKRLEMVISESLRLYPVIVTFVSRNCQQDITVMGQFIPAGANVTLPVWHLHHSAEHWPDPLKFDPERFSEDKGKPH VGAYLPFGLGPRACIGKRFAMLELKATVCKVLRSFRVVQCEETQDPLKVVVPNATAYPKDGVKLKLELRNP >&P450_Is258, 30497.m000022 (fusion of two P450s) MLQLLLDAQAGKDSDTVDADKTECDGGFVISDDKLLANSFILLIAGFETTATSLGFIMHLLSQHPDEQETLHAELVAASP NERLDYERLMRLQRLDMVVQECLRLYPPVVLLLSRACRADTTILGQFFPKGVNIMVPVWHIHHDAELWPDPFKFDPESFT TAKMKMMTQIMQKSADEMLEVLDDHVKSGHMVDMVKISQAFALDVIAKCALAWE VDCQRNPSDPLLLAVQRIFNDSDNFL ILSAVRFPALRKAMERIFLYSSYFKMITHISDKILKVLELRQSGQSPRANDMLQLMLDAQTGSEDANVDFKKRAKAIEDR HLLANCFIFLAAGFDTTASSLSFVMHLLAKYPEEQELVFDEIQKTFPGDAELTYDGLQQLKYLDMVICETLRMYPPVVMF TSRHCKEDTMVMGQLFPAGVNVLVPVWHIHHDPELWPDPQRFDPKRFDGEKSRNSAAYLPFGIGPRMCIGKRFALLELKL AICKIVRKYKVFPCEQTQDPLKFSVPTVVLHPKSPICVKLQQR >&P450_Is202, 17643.m000035 MQVTSAVNR QHQVSKFNLINVDGERWKDMRSLLTPAFTSSNMKKMLPLLDICTDEFLEVLDSLHEQEKAFEIREVFQKLS LDVIVRSAFGVQSNVQKNPGTTGMNAIVK VILDGSTNSARAGWSFLLVTRTIFETTSTALTFTTYLLAKFQDVQDRLRSE ISDVLERDGKFNYDNVFSMRYLDQVITESLRFYPPLTG >P450_Is146, VBpre_P013737 Same as P450_Is202 YIDMYPFKSHIGTLFINHEYQFKDGWLMTCKPYYEDAKTYIAVQVDFFPKVATTMNIKSELKDQKLVNIELHDGVHYSKS DIPIEPSPMLLVKDLDLIKKIQIKDFGNFHGRG QHQVSKFNLINVDGERWKDMRSLLTPAFTSSNMKKMLPLLDICTDEF LEVLDSLHEQEKAFEIREVFQKLSLDVIVRSAFGVQSNVQKNPGTTGMNAIVK ARRQDLLHLMLNAEVQEGEAVNVHQFT AGNDGEAPKSAESSMSARKHRCLSNAEVQANAVLFLVAG >&P450_Is186, VBpre_P009505 33% to P450_Is202 C-helix to mid region 47% to P450_Is146 MTSIILRTHKITKMNLQHASGDHWKNMRKVITRQFTPSRLKKQATLMDQCCSEFMEILESLHAQDEAIEVHSAFQRLSLD VMLLSLFGGEGRTAIGREEAGPEIIKRELKNFMASLGNGWQRFIIDCFPEFSLLMRGLLFLRGYFMKYAVDKIQDEMSKM ISQRLSSSTGGQDDLLQLLITAQTDVGAAATNQRLAMSNGTERSDHAQLNRGGERRGTLSVSEVQANVHSELVDR >&P450_Is236, 18704.m000251 MDSTAALMYGIDLDSFGDLDHPLLHCCEKLFSSVASWQLVMLFTMPSVYKLLLPGYPPKESTEALRKFVSLMIEEKQ KKQ SKDDDILQMLLDTDCGEGDRKESGAKGDILGKG AMTLDEITAQALLFFVAGTDTVMSSMTYATYFLALNPQCQERVLAEI DAAVEKRGVMYESLQDMPYLEACIKETMRLYSPDSVTMRMCTNETTVAGVRFKPGMNIDVPIAGVHYDPEFFPDPEKFQP ER >P450_Is179, VBpre_P007692 Same as P450_Is236 LCLFKTSTLIIFRFRCRKIRRTFTFWNDKGVPYQTFWQYLRVVYDLYTKPLHEVVRKNYETYGRVYGSYQGIVPTLVVGD PDLLSDVLVKDFKSFSDRTEAQKVGNEVWKKLIMNLSGEEWRRARNILSPAFTSTKLKTIFFKLYHIAGRAVTRMENAAM GEQPLAVNEVFENCA MDSTAALMYGIDLDSFGDLDHPLLHCCEKLFSSVASWQLVMLFTMPSVYKLLLPGYPPKESTEALRKFVSLMIEEKQ >P450_Is178, VBpre_P007691 Same as P450_Is236 PVSTWFIQPSVSRLNA AMTLDEITAQALLFFVAGTDTVMSSMTYATYFLALNPQCQERVLAEIDAAVEKRGVMYESLQDM PYLEACIKETMRLYSPDSVTMRMCTNETTVAGVRFKPGMNIDVPIAGVHYDPEFFPDPEKFQPER FLPENKGNLKPLTFL AFGAGPRNCVGMRLGILQVKVALACILEHVRFETCKET >&P450_Is244, 25498.m000014 MTDE QVMERWIKQYGKVFGYYLGEIPYIVITDVDLIKEIFLKRASVFCDRPQQLVNVEPFKSCIIGLEGQEWKKVRSVLN PIFTG SKMKLMTQIMASSADVMLEILDNAVSKAESVDMFRVARGYSMDVITKCAFAWQ >P450_Is162, VBpre_P009238 Same as P450_Is244 MTTVLADVSFWTTLGLGALVLIATGLCFWVLHRRRLHDVLRRNGIPGPEPSLLIGNWTELKKDPV QVMERWIKQYGKVFG YYLGEIPYIVITDVDLIKEIFLKRASVFCDRPQQLVNVEPFKSCIIGLEGQEWKKVRSVLNPIFTG >&P450_Is110, VBpre_P005342 61% to P450_Is244 MEHWIKEYGKVFGYYVGGVPHMVLTDVEMIKQCFVRNASTFHDRPPLPICTGPFASCIIALEGDEWKKIRAVLNPCFSAS KMKLMTQIMGSCADAMIEVVEDHVKKGETVEMYRVSQGLSLDVIAKCAFAWQVDCQKNPNDPLLLSIRKMFVEADDGILR HAIRFPILCKIITSLISFTSYIKTLTRIFDTSSVIELREK >&P450_Is324, 33403.m000007 FISRTCKKDYDYNGLTIPAGISVIIPASSLHRDPELWSEPKKFDPERFSSDNKGSLNPITYQAFGNGPRSCMGMRFGQTA LKLALGKILAKYKLHLDDRHLK >&P450_Is198, 17843.m000016 MALTHPLHLQQYVELSSGIPTNDEKLSRLYGARWRELRTLISPAFNSSKLKRVPHTPRRVPKMTPFATVANAELFMISGL ETVSSALSFTAHLLAKHQDVQDKLRAEVKLLLEKDGNFSYDNIFSLQYLKQVIAESSRFYPAQPGNVTRRCVKDFEFNGF RIPKDTHVLVPVHLMHHDPRYWVEPEKFNPDRFSPENKSTIEPMAYIPFGIGTRNCPASRLAEFELSLVIAKTVAKFKLH LCDEPEKASRF >&P450_Is260, 19432.m000017 LDRTTPSEYVLGDTGIKVSKDCVISVPVYAMHYDPEYFPDPTTFDPRRFSDENIDKIRPYTYLPFGAGPRNCVGMRFALE AVKLSLLHSVHSVQFVRTENTQV PLEFVAGFAAFKAKHITIGIRKRIE >P450_Is040, VBpre_P007140 Same as P450_Is260 MWITSVFFAYFMFSFR LDRTTPSEYVLGDTGIKVSKDCVISVPVYAMHYDPEYFPDPTTFDPRRFSDENIDKIRPYTYLP FGAGPRNCVGMRFALEAVKLSLLHSVHSVQFVRTENTQV NLASRYDFSFSTRCPQGEQTTCVF >&P450_Is199, 25876.m000009 EEWKKVRTVLNATITASKVNRCSRIVSRCAEELLRVLKRHHERDELVDIMDMAEGYSLDVITKCALAWKVNCQQKSDDTL LLGLRRIFEDLDSTVIESTLALPGIRSILKLIYPFTSVSKMLRRIAENVREISTSGVKDKAP >&P450_Is246, 25548.m000013 45% to CYP3A7 HUMAN LDAVSKLKYLHGVVSESLRMFPPGARLERTASNDYVLGDTGIKVPKGCVIAVPVYAMHHEPDYFPDPATFDPSRFSDENI DSIRPYTYLPFGAGPRNCLGMRFALEAVKLSLLHSVHSVQFVRTENTQVPLEFVAGFGSLNAKHITLGIRKRTA >P450_Is141, VBpre_P007330 same as P450_Is246 LNYFKNICLKIIENRKENKSRQEDFLQLMMDAQDGKVTATVENASSTDEKLFNLDSEIKTDTSFAAGVKDEHQLARSTFI FLDKIYNANHNSGLHVLLLILFIATEVMCYFTEIISVRSIDLHHPS LDAVSKLKYLHGVVSESLRMFPPGARLERTASND YVLGDTGIKVPKGCVIAVPVYAMHHEPDYFPDPATFDPSRFSDENIDSIRPYTYLPFGAGPRNCLGMRFALEAVKLSLLH SVHSVQFVRTENTQVPLEFVAGFGSLNAKHITLGIRKRTA >&P450_Is086, VBpre_P010989 74% to P450_Is246 MFPPASRIERSAIEDYVLGDTKIKIPKGCKIAVPVFAMHYDPEYFPDPHAFVPERFSAENVTSIRPYTYLPFGAGPRNCI GMRFALQAVKLCLLHSVHSVEFVRTEKTKVPLEFSKGFGILSAKDVTVGIRERPQ >&P450_Is321, 27092.m000009 EEWKKVRTVLNATVTASRVNRCSGIVSGCAKELVRVLEGHHERDELVDIMDVAEGYSLDVITKCALAWKV >P450_Is125, VBpre_P006892 Same as P450_Is321 EEWKKVRTVLNATVTASRVNRCSGIVSGCAKELVRVLEGHHERDELVDIMDVAEGYSLDVITKCALAWKV NCQLKSDDPL LFGLRRIFEDLDSTAIESTLALPGIRGILKLIYPLTSLSKMLHRIAENVRDTVEKRRLGQSPREDDMLQMLLDAQAGVED KTYNVQKSGLLIEDRHVIGNSLVLLVAGFETTATAIGFTLYVLATNPEEQEKVHSEIDAVLPFDDEISLDSI >&P450_Is319, 28303.m000005 FSNENMGSIRPYTYLPFGAGPRNCVGMRFAIQMVKLCLAHAVHNVRFVRTAKTQ >&P450_Is250, 19037.m000009 LKLINVDGDRWKHLRSLLTPAFTSSNMKKISSVMDACTNDVMEVLDSFSNQDKAFEMGEVYRRFSLDVMLRSAFGVESNI QKNQGITG >&P450_Is327, 33924.m000009 FCSRSFQTTSVTLSFMSLLLAMHSEVQEKVRQEVKAAIGSSGCLDYDTTIHKLKYTTQVMNETLRLYPPSLT FHTRIAKESFEYNGTTFKAGTCILAPVSQIHRDPQYWPEPNKFDPDR FSPENKGSYRKNAFQPFGVGPRCCVGYKLALVQALYITARMVADFKIELGEAQK VFFV >P450_Is037, VBpre_P003489 gray = same as P450_Is327 SPSKV FCSRSFQTTSVTLSFMSLLLAMHSEVQEKVRQEVKAAIGSSGCLDYDTTIHKLKYTTQVMNETLRLYPPSLT VSPLRSPSTCIHSSISYPAYCLAFAICTYFITPSYLFLSNSANIFFG FSPENKGSYRKNAFQPFGVGPRCCVGYKLALVQALYITARMVADFKIELGEAQK GVIEMRSSGMMAAPGNGPWIKFTRL >&P450_Is292, 34813.m000011 LETIASALSFTAHLLAKHQDVQEKVRAEVKSLLEKDGSVHYDNISRLQYLSQVISESLRVYPPIPGQVNRKCVKDFEFNG FRIPKDTLIQVPVRLIHHDPRYWANPEDFNPD >&P450_Is286, 33194.m000007 GNLNYDNIFSLQYLKQIIAESARFYPVQPGNITRRCVKDFEFNGFRIPKDTNVVVPVRVMHHDPRYWEDPEKFDPE >&P450_Is270, 18906.m000014 LSEVEVLAQCVVMFLSGQDSTSSVIAHTVYLLALHPDKQMKLREEVDRCFSSHV >&P450_Is268, 26838.m000018 MVPVLNACAWDTVQSFCDVAAKGVPYDVKQ DQILAQAVLFFLAGVDTSANTLAMSAYHLALNQDVQARLVEEIDQVLLTH KDITLDVVMGLPYLDAFVMEVLRISGPVTM FLGDNRKLIQPFTYLPFGEGPRQCVGMKFALFKVKFCLFHVLSKISFQVCPETD IPPTHQPVILVMIPETVTLKVTRRKPAAVHCALLSE >P450_Is073, VBpre_P008435 same as P450_Is268 VLSR DQILAQAVLFFLAGVDTSANTLAMSAYHLALNQDVQARLVEEIDQVLLTH VSARTAHETANLETKNWRIVNVSSAHTLSTSVHRFPER HHARRCHGPAIPGCVRDGSAAHQRACHDYLFFAFYVCR FLGDNRKLIQPFTYLPFGEGPRQCVGMKFALFKVKFCLFHVLSKISFQVCPETD VSYLFDTHLVLSSQNVITYVKKKKSTQK >P450_Is014, VBpre_P006205 same as P450_Is268 LHHDQRYFPDPEVFDPGS MFLGDNRKLIQPFTYLPFGEGPRQCVGMKFALFKVKFCLFHVLSKISFQVCPET EVSYHFATAFQRRIASLITARHIISLS >&P450_Is195, VBpre_P001090 40% to P450_Is330 VSNATGNPLWDRMMLNSPEEEWKATRTMMSPAFTTSRLKAVSNQFEPPSVSNIFTSFHKKKKKKRQKRNRMMFESFAMDT TAALVYSLDLNTHENLDHPLVKCCKGFFGNLGGWKMILL >&P450_Is252, 28873.m000008 IEDIAAQCMLFFVAGSDSVTLALTWTAYSLALHPECQEKVIEEIDNAVKQVSSQLV >P450_Is151, VBpre_P013808 same as P450_Is252 76% to P450_Is330 SYEGFVPTLVVGDPVLLRDIYVKDFKSFSDRIRFEDVLQLCLDAVMSGRSPDNFKISE IEDIAAQCMLFFVAGSDSVTLALTWTAYSLALHPECQEKVIEEIDNAVKQ NGVTYESLKDMPYLEAAINETLRLYTADSL >&P450_Is234, 31356.m000015 FETIS AAMTFMAYILAKHQDVQDKLRTTIIKALDKNMESYVETILRIEYLDQVTLEALRLYPPVAGFITRTCEKDYHYKG LKIPSGMTILIPVHQLHYDLNLWNQPEAFDPDRFSACNKSILNSVQYQAFGNGPRRCMGMRFAQLELKIAFAKILANYSL FLDERHIGEDQLKLKTSFIFANPRDGVWIKLKKVSRQSCDNKAS >P450_Is005, VBpre_P001192 Same as P450_Is234 AAMTFMAYILAKHQDVQDKLRTTIIKALDKNMESYVETILRIEYLDQVTLEALRLYPPVAGFITRTCEKDYHYKGLKIPS GMTILIPVHQLHYDLNLWNQPEAFDPDRFSACNKSILNSVQYQAFGNGPRRCMGMRFAQLELKIAFAKILANYSLFLDER HIGEDQLKLKTSFIFANPRDGVWIKLKKVSRQSCDNKAS >&P450_Is232, 24295.m000013 FVTRLVE NELDVGCVKIPEGVSIIIPTYLLHHDPELWQDPTSFNPERFCPEHFEHEDAGAFQPFGAGPRNCFAMAFSKNV IMLLTAKVIAKYRLVLTQSDHE VSFALF >P450_Is155, VBpre_P013170 Same as P450_Is232 MPVRSQPVTERTLKTSSSSDKWRQSTSDTRDDGTRCRVVPRSGCRTTETGVSRGSASHWPSDGEMVDFDRRYGRRVEQLS HGAAVGCCSLAGMAADGETRAMQKPGLATLRCEVAREKIPKPRSQEKDPEHLWPLRPRNGWTARRREEQRQ NELDVGCVKIPEGVSIII PTYLLHHDPELWQDPTSFNPERFCPEHFEHEDAGAFQPFGAGPRNCFAMAFSKNVIMLLTAKVIAKYRLVLTQSDHE >&P450_Is105, VBpre_P008177 82% to P450_Is232 HGVSSSRHLCIFRFVTRLVEKELDAGCVKIPEGVSIVIPTYLLHHDPELWQDPGSFDPERFRSETFEPGDAGAYQPFGAG PRNCFAMAFSKKAIMLLAAKVVAKYRLLLTRADHEADLTDDDMEDLLVLGHVKRGLYAKFEKY >&P450_Is230, 18866.m000097 AEKSTKINQKRRMTTEEIQANASTFLIAGFETTGTTLAFSAYLLAKHPDIQDKTREEVKSIIEKE NGLTYDGVFSMRLLD QVISEVLRLYPPVVGFITRRCDNEYEYEGLKIPSGITVVVPAYQLHHDPEYWENPEEFDPERFSPENKDKIEPMAYQPFG NGPRNCVAMRFGQLTLKMTLAKLLSKYKFTLDEERHKNGLKIGSSFTLAYPEGGVWIYINEL >P450_Is079, VBpre_P009103 same as P450_Is230 MQ NGLTYDGVFSMRLLDQVISEVLRLYPPVVGFITRRCDNEYEYEGLKIPSGITVVVPAYQLHHDPEYWENPEEFDPERF SPENKDKIEPMAYQPFGNGPRNCVAMRFGQLTLKMTLAKLLSKYKFTLDEERHKNGLKIGSSFTLAYPEGGVWIYINEL >&P450_Is228, 29385.m000008 SWPEPSRFLPDRFAEDHPERHPLAFIPFGLGPRSCFGKRLALLEVKMALCEILRKYRVIPSEETVDPIPVTVPNLLLRPV GGIKLKFESKAER >&P450_Is222, 31953.m000007 LTEDEALAQCVLFFTAGLETTSTTIAFAVYQLAVCPDIQDRLRQEVDDCFAKHGPEPSLDAVSKLKYLHCVVSETLRMYP PAL >&P450_Is012, VBpre_P009903 84% to P450_Is222 MVDAQESGITEVGSDGVQDMENSLYNLGSEQKSETSFITKS LTQDEALSQCVLFFTAGFETTSTTIAFAVYQLALCPDIQ DRLRQEVDDCFEKHVSLPNTS >P450_Is188, VBpre_P012068 Same as P450_Is213 IMLPFSMEISTLTVVVALIVVTAMSALLWVLNRRHRHGLLRRYGIPGPRPDLLDGNYAQLKENRIEVMERWIKEYGKVFG YYVGDIPYIVLTDVEMIKQCFVKEASTFHDRPPFPVVVEPFLSSIVGLEGDEWKKVRTVLNPSFSASKMKLMTQIMSSCA DATLEVVEDHVKKGEVVEMLRVRITMSAEDRTMLPFEDV VDCQKNPNDPLLLSVQTVFHDVENSSFQQVIRFPILSKIIS RLFSFTSFGKMTTRVCDNIRHVIELRRTRQSARTTDMLQMLLDAQAGVEDSTKVTGQVKKLVEDRHLIANCFVFLIAGFE TTASSLAFTIHLLAK YPEEQDRILDELNEVFPEENQELTYDGIQQLKRLDMVLCESLRMYPPVILFVSRVCLEDTTVMGQ FFPAGTNIVVPTWHIHYDPDLWPEPFKFDPERFAEGKNTGHSAAYLPFGLGPRVCIGKKFALLEIKMALCKLIRKYKIRQ CEETQD >&P450_Is213, 22759.m000029 MCKCWIGLNS VDCQKNPNDPLLLSVQTVFHDVENSSFQQVIRFPILSKIISRLFSFTSFGKMTTRVCDNIRHVIELRRTR QSARTTDMLQMLLDAQAGVEDSTKVTGQVKKLVEDRHLIANCFVFLIAGFETTASSLAFTIHLLAK TFQV >&P450_Is214, 22759.m000030 MERWIKEYGKVFGYYVGDIPYIVLTDVEMIKQCFVKEASTFHDRPPFPVVVEPFLSSIVGLEGE >&P450_Is109, VBpre_P005340 75% to P450_Is214 MDISTLAVVMALFAVMVVTAVWWVLKRRHQHGLFRRHGIPGPRPDLLDGNWAQLKEDRIEV MERWIMEYGKVFGCYVGGVPHMILTDVEMIKQCFVRNASTFHDRPPFPICTGPFASSIVALEGD EWKKVRAVLNPCFSASKMKLMTQIMGSCADVMIEV VEDHVEKGETVEMYRVSQGLSLDVIAKCALAWQVDCQKNPNDPLLQSVRKMFQEIDDSVLRQAIRFPILCKIISSFLFFT SYNKTLTGIYDNVRHVVEL >&P450_Is029, VBpre_P005781 73% to P450_Is214 MDISTFTVVAALIAVTAVTAVLWVLNRRHQQGLFKRHGIPGPRPDLLNGNWAQLKEDRIEV MERWIKEYGKVFGYYIGEVPYMVVSDAEMIKQCFVKEAYTFHDRPRFLISVEPFASCIIMLQGEEWKKVRTVLNPSFSA >&P450_Is212, 18444.m000030 GLPEFSVVWKMLHSLVLSLGLHPLARLRKIYRRLMTENDFPADPEKSDLVTLMLHAAAEAKAQPGSQPANDAPNQEKFRY DTE MESNALIILIAGSVPICKALSSCAFFLAKYQDIQKKARAEVEAALAQDGKLTFDNISAMRYLKQVLLESLRYTSSAF GFNTRITGQEHSYKGLTIPKGVTVVVPSFDLHNDPDLFSKPELFDPERFDGKGKSAEDTAALQVFNNGLGTCVGMKLAQV EIVLALASLLAEYRLVLDETRHTGGRQESHMIARNFKNPEIWIKFENIVKPSASSNGTAFN >P450_Is025, VBpre_P011039 Same as P450_Is212 MESNALIILIAGSVPICKALSSCAFFLAKYQDIQKKARAEVEAALAQDGKLTFDNISAMRYLKQVLLESLRYTSSAFGFN TRITGQEHSYKGLTIPKGVTVVVPSFDLHNDPDLFSKPELFDPERFDGKGKSAEDTAALQVFNNGLGTCVGMKLAQVEIV LALASLLAEYRLVLDETRHTGGRQESHMIARNFKNPEIWIKFENIVKPSASSNGTAFN >&P450_Is207, 29693.m000013 IKVQKKLTPTEVYVNTGVLLIAGFGTTSVALSNLSFVLAKYPEVQDKVREEVNAAMRKHGRINYAAVTEDLKYLSNVVDE TLRIYPVVVA FNTRSALNDFEYEGVKYKAGLSIMSPTIEIQKDPRFWPEPEKFDPDR >P450_Is121, VBpre_P013900 Same as P450_Is207 MTGTFYNGDVPTLVVKDLDFLSYVFIKNFSNFMNRGPRSMDILQIMLEAETDESFEETEVKNGE IKVQKKLTPTEVYVNT GVLLIAGFGTTSVALSNLSFVLAKYPEVQDKVREEVNAAMRKHGRINYAAVTEDLKYLSNVVDETLRIYPVVVA >&P450_Is206, 21755.m000024 ENIRRLSEEEVVLLTTVLFLGGFQTTSITLSFMSLLLAMHPEVQEKVRQEVKAAIESS GRLDYDTTMHKLKYTTQVMNETLRLYPPSLT >&P450_Is115, VBpre_P006308 77% to P450_Is206 MNDAFQALSLDFVCRAAFGMDTDFQHNLACPFYVKAKNIVPGMMKGFFHAVAQSSTTLGKVMKPFFWLNRMLGNFSMEIF AREMKKVVKLKTQNEVTRQRDMLQNFLEAEVHAIQPKNGMTLKNNNISETGNKL EDVGHLSEEEVVLLTTVVLVGGFQTTSVTLGFISLLLAMHPNIQEKVRGEVKAAIESS VTIFLFNSKYSAIDNIQAP >&P450_Is318, 28153.m000007 GCLDYDTTIHKLKYTTQVMNETLRLYPPSLTFHTRTAKNSFEYKGTTFKAGTCIMAPVMQLHRDPQYWTDPNKFDPD >&P450_Is323, 32914.m000009 DKKRSLDNAEIQANAIVFLMAGFETTSTALTFTTFLLAKFQGVQNRVRSKITAEVERD >&P450_Is253, 22885.m000008 LERYGPSDYGLGDTGIKIPKDCVIAVPVYAMHHDPDYFPDPSKFDPDRS >&P450_Is245, 25532.m000011 MIPYMSQVADIFVEILGEKADEGKEYPMLCLFQGLTMDYVGRAAFGFDCTFQRDLKHPFLRTAQSVLPGVMTGPFHFLA >&P450_Is241, 27427.m000011 MKFLGVPDWIILVVTALVLLYLVYEGGKPVLFVADPELVKLVLVKDFPSLPNRRVVNLFDPILDNMMLITPVEKWRRIRP AVSPAFSTGKLRKVCVQLYVLFPGIFKLLGMRAFNSDILDYFKNICLKIIENRKENKS >&P450_Is240, 24024.m000011 LIRRCTQETSVAGIKVHPGMSIEIPIRGVHRDPEFFPEPECFKPE >&P450_Is237, 24514.m000011 CTQETSVAGIKVYPGMSIEIPIRGMHRDPEFFPEPECFKPERL >&P450_Is210, 25064.m000003 SHAQIINFFDPLLDNMLTIAPAEKWRRIRPAASPAFSTGKLRKV CYP4 clan (56 sequence pieces, 39 different non-overlaping sequences, some will join) >&P450_Is301, 35785.m000085 heme region MIYFLQRHQKLYDDPNSFVPERFQENNGRHQYAFIPFFGGQRNCIGQRFAVLKAKVLVAQVMRRFKIESKLPESELQLEI GIVLRPSQNLDVKLTRRNRTL >&P450_Is302, 35785.m000087 47% to CYP319 tick, (46% to human CYP4V2), 45% to CYP4W1 tick SVLTSQKTTRKSFNYTFLHSWLGTGLLTSFGAKWKQRRRMLTPAFHFRILEDLVPTINEHARKMVKRLNQCSGNAATDIV SFSTECTMEILLETIMGVTTANHHEDIGSYVEAIKNLTLKFMLRFQNPWLYLDSIFYRTSLGRECAHTLSVVHSFSKKVI KKRREELVKERSTVTAVPTSDNELRGKKLPTFIDILLQHSLDFDALLTDDDIREEVDTFMFEGHDTTAVAIAWCIYLIGL HPEVQKGVHEELDAIVGDEPEKNITLEDLKKLTYLDRVIKECQRLYPSVPLIGRTASEDFEMGGHLIPAGANIGVFIYAL HRDPDVFPKPEEFDPDRFLPENSEKRHPLSYLPFSAGPRNCIGQKFASMEVKIIVGHIMRSFIVQSMDPRDKLLVSLEIV LRVANGLRIKVVPRASSKGTSS >P450_Is093, VBpre_P010592 Same as P450_Is302 MLQPTLFRFRQSVLWKSYW ETIMGVTTANHHEDIGSYVEAIKNLTLKFMLRFQNPWLYLDSIFYRTSLGRECAHTLSVVH SFSKKVIKKRREELVKERSTVTAVPTSDNELRGKKLPTFIDILLQHSLDFDALLTDDDIREEVDTFMFEGHDTTAVAIAW CIYLIGLHPEVQKGVHEELDAIVGDEPEKNITLEDLKKLTYLDRVIKECQRLYPSVPLIGRTASEDFEMGGHLIPAGANI GVFIYALHRDPDVFPKPEEFDPDRFLPENSEKRHPLSYLPFSAGPRNCIGQKFASMEVKIIVGHIMRSFIVQSMDPRDKL LVSLEIVLRVANGLRIKVVPRASSKGTSS >&P450_Is303, 35785.m000088 SGNKWRRRRKMLTPAFHFRILEDFIPVFNEQAVIFVRNLKEHVHKKYIDIVPLVTLCTLDIICETAMGVKVDAQLNSNSH YVRSLYEVGETFMARVMRPWLWPNYVFYMSSFGKKFKDNLAQLHNFTRK GHDTTAMGISWAMYLIGLHADVQQKIHEELD GIFGEDRERPISPDDLKEMKYLECALKESQRLFPSVPFIGRELMEDVVVNGYTVPRGTTCFLFTFMLHRDKEIFPNPEVF DPERFRPENCVGRHPFAYVPFSAGPRNCIGQKFAMMEEKVVLCSVLRNFCIHAVDFRDKIHLVAELVTRSKHGLRIRLKP R >P450_Is101, VBpre_P010603 Same as P450_Is303 LQVILSSNTVLDKSFDYTLLHPWLGTGLLTS SGNKWRRRRKMLTPAFHFRILEDFIPVFNEQAVIFVRNLKEHVHKKYID IVPLVTLCTLDIICETAMGVKVDAQLNSNSHYVRSLYEVGETFMARVMRPWLWPNYVFYMSSFGKKFKDNLAQLHNFTRK VIRERKAELLEQKVIDGLTIGDQVIGQKRRQAFLDLLLSHHIQDSSLTEEDIREEVDTFMFE >&P450_Is096, VBpre_P010596 63% to P450_Is303 GHDTTAVGISWALYMIGLHHHVQERIQTELENIFGTDTERNATMNDIRSMKYLECVLKESQRLFPSVPLIARLLQQDWKY DKYIMPKGTVCLVSIYSLHRDPDAFPNPEEFIPERFLPENCTGRHPFAYVPFSAGPRNCIGQRFAMMEMKTLVSRILRNF TLHSMDQRDKVQLAAELVLRPRDGLRIKLKCRKKT >&P450_Is152, VBpre_P002000 58% to P450_Is303 VPRGCTCIILSQMVHKDPRYFPNPSVFNPDRFLPENCKGRHPYAFIPFSAGPRNCVGQKFAMMEEKVLVSAVLRQFRIKS LDHRDRLILVPLPLLHPRSTQGGIRVRFTPRERRQPPA >P450_Is091, VBpre_P010590 Same as P450_Is301 MDSAKVSDTLKTVLRPTVATTVVAWLVVGTVSLGLLLPVVRLLARWIRMYWILRHMKRPTRVCPGYWFVPELFVVRYWID THLSMAARFFNFLKASTATYRENDLVVFFNGPQAIVVTVTPAAVEALVKSSNNINKPFIYHFMEPAMGTGLIVSEKNVWK PRRKTINPAFHARNLDSYVPIMSRRLERFARKLEEINDSASGYFNIMAPVRAATFGVLMETVFGISDIEDEEFEKKGHIK RMQIFCDGFVSRICNVAYWWDFIYELSSEGKNHHRVSRILRDYCRQVITARKEELMDKGHVRNSMRSFLDILLQMHMQDG TLTESDILDETVTIIGAGFDTTASAAAFCLYLLGNHLEVQEKLREELDRVFGDDVDRPVTLDDLRDLPYLDCVIKETLRL YPSVPVVARYIDEDMKIGEQLIPKGTTVTT MIYFLQRHQKLYDDPNSFVPERFQENNGRHQYAFIPFFGGQRNCIG EL >&P450_Is100, VBpre_P010601 55% to P450_Is302 TLEIRVAHSVEYQSHGLYRFYIGHVPTVVVYRADLIEIVLTNTLSKSIDYSLLHSWLGTGLLTSSGSKWKTRRRMLTPAF HFRILDDFVLPINEHTKHLVTRIRQLSEQDDWVDVVPLAASTTLDVLLETIMGITTSQQQPECQSYVKAANFLADQMVFR AQTPWLLLDFIYYRTEYGHRYKAATNLVHTFSTQVIQKRRKELIKERSTAQAPLADLTKPQRKRLRTFLDILLCYSLDSD DSFTDEDIREEVDTFMFEGHDTTALAIAWALYMIALHPEIQQKIQQELDAVLGNDLEKNISMNDMKEFKYLDCVTKECQR LYPSVPFIGRAVTKELRLGDYLLPEGTTVDIFIYALHRDPKIFPDPEVFDPERFSSENSASRHPFAFIPFSAGSRNCI >&P450_Is098, VBpre_P010599 47% to P450_Is303 LKWSAGISISLALLLGVCVSVARWIQLKTLRQLQHLPGRREVLPFLNDYALFRACSQQESPAAFNTLFFNAISGFHARFQ RYGMHRIYTGLSPLIIVYRADYVEEVLKSNTLLKKGAVYDMLHSWLGTGLLTGTGNKWRTRRRLFTPAFHFRILDDFTPT INAQSMILADILGKMSLEHNGVDVVPRVTLCTLDIVCETIMGRVINAQSNQDSEYVKAVNRLGELFLERILTPFARVERI YKMTSNG >&P450_Is027 VBpre_P005914 70% to P450_Is302 MLPAIQALLSFGCLFLGGAAFLLLSVLGAFHAARRATWKHVKTLPGPDGSIPLLWIVRQHFRIARVKHMVPYNASAMETH LGICSQYRKKGLYRFYVGNQLHVMIFKPELIESVLTSQKTMSKSFNYSLLHSWLGTGLLTSSGAKWKQRRRMLTPAFHFR ILEDFVAPMNEHARNMGKRISQFSESDETDVVPFLATCTLAILL >&P450_Is094, VBpre_P010593 54% to P450_Is302 MYRFYVGPLPNVMIFKAELVEAVLTSQSTMSKSFDYSLLHSWLGEGLLTSSGAKWKQRRRLLTPSFHFRILDEYVAPMNE HARHMVQEIGRHAGTEEINLIPLSTSCTLGILLETIMGVEADKQDVSTRSYVGALKILSDQITLRSQTPWLLVDPIYYRT EYGKLYRRNVEVVHDFTRKVITERRKQLMSEKSASIPTKIENNEFQKKKLLTFIDILIQQSMNSDAHLTDDDIREEVDTF MFEGHDTTQMAISWCLYLLGLHPKVQEKVHEELEEVLQGDLEKDVTM >P450_Is004, VBpre_P000914 same as P450_Is317 LFVCLFFSHSTGNKWRSRRRLFTPAFHFRILEDFSSAINSHSMVLADILGKKSLDHNGVDVVPKVTLCTLDIVCETIMGK VLNAQSNEDLAYVKALLRYSALVMQKFEQEKRSEIKAAQVSKYRSCARVICTVLKLLELCYCVDISFVTNQSTLVSQIPM EEGITPLNTIAASLIFFTICLQ GHDTTAVGISWALFLIGLSPLEQQKIHDELDFIFGDDTERHVTIEDMKEMRYLECVIK ESQRLYPSVPFYSRLCEEPFELGGTMLPKGTVVQVSNYFLHRDPKVFPKPEEFRPDRFLPENSKGRHPFAYVPFSAGSRN CIGQKFAMSEEKIVIANILRRYKLRSLDQRDQVGLIADMVLRPKSGIRIKFIPRTSSKGA >P450_Is011, VBpre_P003620 1 aa diff to P450_Is317 SK GGTMLPKGTVVQVSNYFLHRDPKVFPKPEEFRPDRFLPENSKGRHPFAYVPFSAGPRNCIG KVVTLFRVMSEHFSK >&P450_Is099, VBpre_P010600 79% to P450_Is317 GTSLPKGTAVQVAAYFLHRDPKVFPKPEEFQPERFLPENAKGRHPFAYVPFSAGPRNCIGQKFAMSEEKIVLANILRKYK LKSLSHRDEVGLVAEIVLRPKNGLRITFTPRATP >&P450_Is013, VBpre_P009931 90% to P450_Is317 YVRFQGHDTTAMGISWALFLIGHSPEAQQKIHDELDSIFGDDTERHVSHEDMKEMRYLECVIKESQRIYPSVPFYSRLCE EPFELGELPHDIQAILPLVGRQRSR >&P450_Is008, VBpre_P012203 78% to P450_Is317 MFFSSGSTGEKWRSRRRLFTPAFHFRILEDFTSTINNQSTILASVLGKTSLEQNGVDVVPKVTLCTLDIICETIMGKTLN AQSNEDSVYVKAVHRLSELFMERMATPLARSESLYRMTAKGKEYTHWLNKLHTFTREVVAERKKDMKATISSGSLLDDEE DNGCNYMKRKRPFLDTLLVEHFKDPQNITEEDMREEVDTFMLAASLLIGLNFFWALLLIGLSPVEQQKIHDELDSIFGDD TERHVNHEDMKEMRYLECALKEAQRIYPSVPFYSRLCEEPFELGGTILPKGTVIKIAGYFLHRDPEVFPKPEEFHPERFL PENSKGRHPFAYIPFSAGPRNCIGQKFALPVVKIVVANILRRYKLQSLDHRDQVLFFSEMVLRPKNGLRIKFIPRISSKR A >&P450_Is283, 34698.m000033 51% to CYP4CF2, 58% to CYP4V2 human (probable ortholog) VIRERKEVKLAEQRLIEPSSDIKKRPMFLDVLLDHHITEDSISEEDIREEVDTFMFE GHDTTSAAISWCIYLLGRNPEMQ KKVQDEMDAIFANDVDRYATVADLKEMKFLECCIKETLRLFPSVPIIGREVHKEFSVNGNVVPQGAIVVVFSYMLHRDPQ SFPRPEEFFPERFLPENSLGRHPFAYVPFSAGPRNCIG QRFALMEEKIVLSNLFRRFSVTSLVPRHNLKLAGELVLRNQN GIEVELTPRQPHAPAAIAQDKP >P450_Is051, VBpre_P007473 Same as P450_Is283 ERIGKIYCPTGKANCLFQ GHDTTSAAISWCIYLLGRNPEMQKKVQDEMDAIFANDVDRYATVADLKEMKFLECCIKETLR LFPSVPIIGREVHKEFSVNGNVVPQGAIVVVFSYMLHRDPQSFPRPEEFFPERFLPENSLGRHPFAYVPFSAGPRNCIG EFSNLASFSFVCLFVCSCVRVCLCVLRYQL >&P450_Is281, 25312.m000009 37% to CYP4C3 Drosoph. 39% to CYP4V2 human AVLSSTSNLNKSFIYRMMTPWMGNGILT SDKDVWRTRRKILTPAFHFRILEDYTPIINRRTTELLQKLRKMEGEFFDMLP VLRMAAFGMLFETAMGVQIDEAEVERRGLLRVTDELAASVIGRIINIFHWPDFVFNLTKKGQRFYNNVEYIRSYNEQIVK KRKAEYKVGLEDSNKRKSFLDILLRMHLEDGTLTEDQVRDEVATVFIGGFDTTATAASYTLYLLGHYPEIQAKVHRELDE VFGDDWDRPVTLEDMKNLKYLECVIKESMRLYPPVPVVARNIDEDMKVGEYTIPRGTVAFAVIFALHRHPRVYENPNDFI PERFLEKKERHPYAYVPFSGGSRNCI >P450_Is140, VBpre_P003290 Same as P450_Is281 LPY SDKDVWRTRRKILTPAFHFRILEDYTPIINRRTTELLQKLRKMEGEFFDMLPVLRMAAFGMLFETAMGVQIDEAEVE RRGLLRVTDELAASVIGRIINIFHWPDFVFNLTKKGQRFYNNVEYIRSYNEQIVKKRKAEYKVGLEDSNKRKSFLDILLR MHLEDGTLTEDQVRDEVATVFIGGFDTTATAASYTLYLLGHYPEIQAKVHRELDEVFGDDWDRPVTLEDMKNLKYLECVI KESMRLYPPVPVVARNIDEDMKVGEYTIPRGTVAFAVIFALHRHPRVYENPNDFIPERFLEKKERHPYAYVPFSGGSRNCI GQRFAQIEDKIMLAQILRRFKVESKVPIEELQLQIEIVLRPVEGIELKLTKRERSA >&P450_Is095, VBpre_P010594 60% to P450_Is281 NKYVKKHPQGFDTTATAAAFAVHLLGNHPEAQAKIHDEIDSVFGNDRGRPVTTDDIRNLKYLDCVLKETLRLYPPIPAIA RKIDEDVVIGKHTIPKGTVSIVMLYFLHRHPRFFEKPDAFFPERFLDYADRHPFLYIPFSGGARNCIGQKFAQLEDKILL THIMRHFKVESELSMEQLQMSLELVLRPTQGLHLKVTPRVAGVEKTTN >&P450_Is092, VBpre_P010591 62% to P450_Is281 MYVHVLFKVIKTRKQTYKAGLEDNFKRSSFMDIILRMHIEEGMFTEDEIREEVNTFMIGGFDTTATTAAFAVHLLGNHPE VQAKVHEELDIVFGSDRERPVTDEDMKQLTYLECVIKEALRLYPPTPIIARNIDQDIKAAGYLIPRGSVAVIPLIFLQRH PKYFDRPEDFVPERFMEAQERHPFVYVPFSAGPRNCIGFKFAQLEDKILLAHIMRSFKVVSKIPMEDVQLSL >&P450_Is259, 19547.m000015 no ESTs 55% to P450_Is281 NILLQKSMRVYPAVLLLARMIDKGIKIGEQTIPKGTVALAFIFYMHRHPKHFENPD IFMPERFLETKYSHTFQFLPLSAG PRNCIRKTL >&P450_Is103, VBpre_P010605 40% to P450_Is281 MERLNKPWLWWNVAYSLSHQNRNFKTTALQINQFVREVIQERKKVLCSGEQSNGPNCAKAFLDLLIKHHIEDKSFTEKDI NEEVNTFLFAGHETTAIGMTYVLYLLGLHPDIQEKVARELDSIFMGDTEREITREDISAMKYLECVIKECQRLYTIVPIY GRRIEEDMSI >&P450_Is215, 29063.m000022 (two genes) 35% to CYP4V2 human, 37% to CYP4CF2 mite MTPAFHVRVLDNYMSVFNESADLLVKHMCKVADEAPDEPIRLFKSMQKCAMDIIGEVTMETKFQLQENKNISFMNAFNRV MFLVSVRAFRPWLWIQKLYDNTLEGKSYEADVQEMITLSNSIMYKQKDKLQSTEVLPTTGSEDDELNIKRETILMNILLR RHMQDSSYTLDDVRNDNDTIVSAGTDTITTCMCFTLHYLGLYPEAQARAHQELDEIFGDDTDCEITATHIRQMKYIECCL KESLRLYPSFPVIGRVLDEDVTMEGHVIPKGVMCFISIYSLHRNPKYFKDPEEFIPERFLSEEIKTRHPFSYIPFSGGSK NCLGQKFAMLEMKLLLAKILLKCKIVSAEPLDRLNVA TDEIWRLKRKL MTPAFHFRVLDNYLRIFNENGDRLVRTIGEAI DEAPEDPVRLFKTTQKCAMDIIGEVTMGEKLGLQDDKNLNFMSSFNRVMFLVSVRFFRPWFWNQKIYDSSSEGKLYNRDL EEMMEFIHSIIQRR SQASQSEKSLPKYSPDDQHDDETDCSENKNTLMNLLLKKHREDHRYTLDDVRRDIDTIIAAGNDTL TTSTCWTLNLLAHNRDAQRKVHAELDEIFGGNLDGEITADDLRKMKYLECCLKESLRLYPAFPLIGRVLDEDLILGGYKV PEGVMCFISLYSLHRNPKYFKDPESFIPERFMSEEIKARHPFSYIPFSGGSKNCIGQKFAMMEMKLILAKVLRKYQVECK IPMDQLNVA YEVIVKDKGGNKVWFRRRPELCLTLQ >P450_Is062, VBpre_P011782 Same as P450_Is215 (first gene) MGAPSLSASSYLVSLFVRNATWILGVLLCAGLTVPFIRWFRVWKALRPLPGPSDIVPFWFSLSCIKSFLQERRENKYATT RIFSIIRDLGKQYTGKLFKVYVGMTPIVVLHTPDAVEALLTSNTNQKKPFLYHFIAPWLGNFNILLSTGETWRNRRKL MTPAFHVRVLDNYMSVFNESADLLVKHMCKVADEAPDEPIRLFKSMQKCAMDIIGEVTMETKFQLQENKNISFMNAFNRVMFLVSVRAFRPWLWIQKLYDNTLEGKSYEADVQEMITLSNSIMYKQKDKLQSTEVLPTTGSEDDELNIKRETILMNILLRRH MQDSSYTLDDVRNDNDTIVSAGTDTITTCMCFTLHYLGLYPEAQARAHQELDEIFGDDTDCEITATHIRQMKYIECCLKE SLRLYPSFPVIGRVLDEDVTMEGHVIPKGVMCFISIYSLHRNPKYFKDPEEFIPERFLSEEIKTRHPFSYIPFSGGSKNC LGQKFAMLEMKLLLAKILLKCKIVSAEPLDRLNVA YEVIVKDKRGNRVWIRRRTELDSAER >&P450_Is175, VBpre_P013495 C-term part 92% to P450_Is062, N-term part 72% to P450_Is062, missing the middle MGVHVLSTSSYFVSLFIGNVTWILGLLLCAGFVVPTVRWFRVWKALRPLPGPWDAVPFWFILGCFKSVIQEKKANKHATA WIFSKICSMCQQYTGRLFKVYVGMTPIVVLQTPDAVEALLTSSVNHKKPFLYDFITPWLGPLNILVATGEAWRFKRKLMT PAFHFRVLDNYMRIFNENGDLLVKHLCSVVDKSPDEPIRLFKSTQRCAMDIIGE GHVIPKGVTCFISIYSLHRNPKYFKDPEEFIPERFLSEEIKTRHPFSYIPFSGGSKNCIGTQTLL >&P450_Is122, VBpre_P010314 74% to P450_Is062 DRDGEITASHLAQLKYLECCLKEALRLYPPFPLVGRVLDEELEIEGQVIPKGVNCFIALYSLHRNPEYFKDPEKFMPERF LSDEIRTRHPFSYIPFGGGPKNCIGTETLLSICFVRA >P450_Is063, VBpre_P011783 Same as P450_Is215 SQASQSEKSLPKYSPDDQHDDETDCSENKNTLMNLLLKKHREDHRYTLDDVRRDIDTIIAAGNDTLTTSTCWTLNLLAHN RDAQRKVHAELDEIFGGNLDGEITADDLRKMKYLECCLKESLRLYPAFPLIGRVLDEDLILGGYKVPEGVMCFISLYSLH RNPKYFKDPESFIPERFMSEEIKARHPFSYIPFSGGSKNCIGQKFAMMEMKLILAKVLRKYQVECKIPMDQLNVAYEVIV KDKGGNKVWFRRRPELCLTLQ >&P450_Is020, VBpre_P002206 58% to P450_Is215 MDIIAEVTMGKKLGLQENKNPRLVASFNRAMMLVPVRCLSPWFWVQAIYDITSQGKGYKGAVEEMVNLTRSVMRQHLETS NGTKMTSQFSQHDTEADSSKKASLIDRLMKTQSEDEKYTLDDVVGDINTILGGGNDTAALAVCWALNLLGHNADAQRKAH EELDEIFGSNRDGEITADDLKKMKYLECCLKEALRLYPSFPVIGRTLEEDLVI >P450_Is054, VBpre_P011725 Same as P450_Is256 MAWTLYLLGLYPQKQRKVQRELDEIFKDNPDREVTMDDLRRMKYLEACLKEAMRLFPPIPYIGRVLVEDIELDGVVIPKG VTCWISIFTLHRNEKYFHKPEEYIPERFLTEEFTSRHPFCYIPFSAGSKNCIG RF >&P450_Is256, 34608.m000037 36% to CYP4W1 tick MFKNRTFKAYIAAVPIVVIQTAEHAEVLLSSAVNLNKPFFYTFTIPWLGPRNLLYVAGDIWRAKRKVQTPGFHFKILEKF MDIFNEHADAMSETLHDMSVKNEQVRINDVTKRCSLDVIGEALLGINLNTQKNENGTYGEYIGGITFLMTIRAFRPWMWL TSVYNWSLEGQWFKKMIHGVDTFSLKVMKERKETFHLFKNQSNPDGPEDEDDAKPERRVAIVDILLDKHLKDQSYTLHEI RKDLDLLLFAGHDTISNA MAWTLYLLGLYPQKQRKVQRELDEIFKDNPDREVTMDDLRRMKYLEACLKEAMRLFPPIPYI GRVLVEDIELDGVVIPKGVTCWISIFTLHRNEKYFHKPEEYIPERFLTEEFTSRHPFCYIPFSAGSKNCIG >&P450_Is257, 34608.m000038 MGLKLHERGVSAIADEYEKDVELVLKLYMKRIMQPWMWADFVYAATTSGRQYAKLVKRLHSFTKK GHDTVTQSLTWTLFV LGIYPDVQSKVHEELDLIFAHDMTRGITRADIADLSYLDRVIKV ILNRQSGFAAGRRKLDDDAFHEAETNEKRLAFLDLL SKHYRKEMITIEDVRQEVDTFMFAVRNYQIPKGTTCFVFTYGLHRDPDHYRDPETFDPDRFLPENCS QKFALMELKVTLA KLLRRYQVKSCHQRDDLLLMADMLLRTRNPIKFQLTERLAPQ >P450_Is055, VBpre_P011728 Same as P450_Is257 GHDTVTQSLTWTLFVLGIYPDVQSKVHEELDLIFAHDMTRGITRADIADLSYLDRVIKVSRAFFYHITVSNASRVRIFRN YQIPKGTTCFVFTYGLHRDPDHYRDPETFDPDRFLPENCSGRHPFAFVPFSAGPRNCVG QKFALMELKVTLAKLLRRYQV KSCHQRDDLLLMADMLLRTRNPIKFQLTERLAPQ >&P450_Is273, 23435.m000009 35% to CYP4W1 TLLSSTGNHGKTFEYSFLTSWLGPRNILTA TGDIWRFKRRLLTPAFHFRALENYMQIFNENGDQLTKRIGALLDEAPNEAIPLFQN TMVYFAE VTMGTKLCLQENKNENFMIWFNRLMFLISVRCFRPWTWLQTIYEMTTEGRVFKETLHNMEAFSYS VRTYICLKN DLEVISKLEPEDNINHASERDSILLDALLKRHLQENRYELEEVKKDIDTILFAGNDTTTSAISWNLYMLGLHP EIQAKVHHELDQIFDGDIDRHITTDDLKQMKYLECCLKESMRLFPPFPLIGRILDHELVIDGHTIPTGVRCFVNIFSLHR NPDYYKDPDSFIPERFMSQEIMNRHPFSYIPFSGGPKNCL >P450_Is088, VBpre_P008297 Same as P450_Is273 LRR TGDIWRFKRRLLTPAFHFRALENYMQIFNENGDQLTKRIGALLDEAPNEAIPLFQN VQKCALDIIGQ VTMGTKLCLQENKNENFMIWFNRLMFLISVRCFRPWTWLQTIYEMTTEGRVFKETLHNMEAFSYS AMRNRLDTVK DLEVISKLEPEDNIN HASERDSILLDALLKRHLQENRYELEEVKKDIDTILFAGNDTTTSAISWNLYMLGLHPEIQAKVHHELDQIFDGDIDRHI TTDDLKQMKYLECCLKESMRLFPPFPLIGRILDHELVIDGHTIPTGVRCFVNIFSLHRNPDYYKDPDSFIPERFMSQEIM NRHPFSYIPFSGGPKNCL GQRFAMLEAKLLLAKVLLKYAIEPTWPLEKLKITFEVILKARGGLRTHIRSRRGLNAP >&P450_Is204, 32461.m000036 I-helix 85% to P450_Is317, 64% to Is303, 45% to Is302 MAISWALLLIGLSPVEQQKIHDELDSIFGDDTERHVNHEDMKEMRYLECAAIALKIWF >&P450_Is317, 20997.m000010 63% to CYP4W1 tick I-helix to end 57% to Is302 GHDTTAVGISWALFLIGLSPLEQQKIHDELDFIFGDDTERHVTIEDMKEMRYLECVIKESQRLYPSVPFYSRLCEEPFEL GGTMLPKGTVVQVSNYFLHRDPKVFPKPEEFRPDRFLPENSKGRHPFAYVPFSAGSRNCIG QKFAMSEEKIVIANILRRYKLRSLDQRDQVGLIADMVLRPKSGIRIKFIPRTSSKGA >&P450_Is113, VBpre_P006304 62% to Is302 EVDTFMFAGHDTTAMAIAWNCYLIALHPEVQKKVQEELDMVLGEHKTEDISTENLKDLKYLECVVKESQRLCPSVPVIGR TVTKPFTLGNYVLPEGTSVEIFIYGLHRDPEVFPDPEVFDPDRFLLENCASRHPFAFIPFSAGSRNCIGKYDR >&P450_Is097, VBpre_P010598 43% to Is302 LFQELLTSNVILDKGKEYDIIRPWLASGLLTSAGSKWKLRRKLLTPAFHFRILEDFLPIVNTQSRVFVENLRSQGKERSY NIVPLVTMCTLDIICETIMGYVINAQKNKCSDYVQAIQVVGEAFTLRLESPAFWIEPIFRLSQSGRQFYDSVKELHEFTT KVIQERKKELQNEPREAFDNADDDDVYGMKSSHKRTFLDILLREHLKDPHNFTEEDVREEVDTFMFEGHDTTAMGISWLY LIGLYREQQDLIHQELDSIFGDDKVRQITSNDLKEMKYLECCLKESQRLYPSVPFIARTCSEDLIIGDYIDLPLFT >&P450_Is298, 35258.m000099 32% to CYP4C2 human MYNFIDSWVGQFNILVT TDEVWRFKRKLMTPAFHFRVLKNYMRIFNEHGDGLLKNICAAIDKAPKDPVRLFETTQKCAMD IIGVPSEYIENELYVCYNYRTGSVFRCLFFSAMFLLSTRSFSPWFWNQTIYDNSSDGKHYNGDIREMMEFTHSVSKFDSD LFYNERIISKCLPHDNEFDFSVKNNTLMDLLMKKHRDDKRYTLNDVRMDIDSIIGAGNDSTTTAICWTLNLLGHNTDAQA KVHEELDEIFGSINDGEISADDLRRMKYLECCLKEALRLYPSFCVIGRLLDEDLIMDGHRVPKGVTCFVNIYSLHRNPKY FKDPEQFLPERFLSDENKSRHRFSYIPFSGGPKNCIGQKFAMIEMKLILAKVLRKCEVKSKIPLDRLKVAYEVITKDK GA SAAKRAEGADSKRLVLLAEDSWVPLDRLAAQSSSFRHNYNPFLHMPSYPAYPGRNAALGLEEDLLTEAEAEPTLKVYKAD AEYPPLNLKNRKKLYAVGYIYMLDFLEDTYLRRRRRR >P450_Is082, VBpre_P009117 Same as P450_Is298 TDEVWRFKRKLMTPAFHFRVLKNYMRIFNEHGDGLLKNICAAIDKAPKDPVRLFETTQKCAMDIIGVPSEYIENELYVCY NYRTGSVFRCLFFSAMFLLSTRSFSPWFWNQTIYDNSSDGKHYNGDIREMMEFTHSIMQQNSKLSDERIISKCLPHDNEF DFSVKNNTLMDLLMKKHRDDKRYTLNDVRMDIDSIIGAGNDSTTTAICWTLNLLGHNTDAQAKVHEELDEIFGSINDGEI SADDLRRMKYLECCLKEALRLYPSFCVIGRLLDEDLIMDGHRVPKGVTCFVNIYSLHRNPKYFKDPEQFLPERFLSDENK SRHRFSYIPFSGGPKNCIGQKFAMIEMKLILAKVLRKCEVKSKIPLDRLKVAYEVITKDK GGNKIWIRRRTAFCSTLQ >&P450_Is304, 35433.m000007 ERVISDWMYFCLAGKRMCPGETLTTVEIFLYLTSLLQRFDILPEEGKAINLTPVS >&P450_Is201, 20358.m000017 green = 81% to CYP4D23 YIPFSGGSKNCIGQKFAMLEMK EPRLWLKIPSFANTFLLSPPPLFSFSYAIKIDWWKTSPEVQTGKETQHRVRMADVGLLIYFDSCLL >P450_Is156, VBpre_P013193 Same as P450_Is261 MTPVVVIDTPGAVEVR TGHAWRSKRKLLEQSFHSSRALEHYVHIFNENGDLLVGNICSIIDRSPNEPIRLFKMVQKCALDIIA DGHRIPKGVMVTVDIFSLHRNPTCFEDPEKFIPERFMAEENKTLRPFSYIPFSGGQKFAMLEMKLLMAKVLRECKIV SSEPLENLDVAYEVIVKDIG >&P450_Is261, 19455.m000047 MTPVVVIDTPGAVETLLTSSVNHRKPFIYDFINSWLGQQNILVA TGHAWRSKRKLLEQSFHSSRALEHYVHIFNENGDLLVGNICSIIDRSPNEPIRLFKMVQKCALDIIA ECWIKN >&P450_Is262, 19455.m000048 42% to CYP4V2 human MTPAFHFRILENYMAIFNQNADLLVRRLCSFVDKAPSEPIRLFENTQKCALDIIGDTTLMNLLLRAHLQDNKYTEEDVKK DIDTVFGAGNDTTTSATCWTLYLLGLNSKIQAKVHHELDEILGRDTDREFTTDDLRRMKYLECCLKEGLRLYPSFPYIGR VLDHDLEIDGYKIPKGVSCFVNIYSLHRNPEHFKNPEEFVPDRFMGHETTRRHPFSYIPFSGGPKNCLGQRFATVESKLL LAKVLSKFTIESTRPLEQIKVTFEVIIRARGGHQVWLRRRTQMDSFQQLN >P450_Is059, VBpre_P004563 Same as P450_Is262 for part of seq, rest does not match. Hybrid? WRFKRKL MTPAFHFRILENYMAIFNQNADLLVRRLCSFVDKAPSEPIRLFENTQKCALDIIG EVTMGAKLHVQEGKNLNF MSSFNSASLLVGLRALRPWLWLQFIYDHTSEGKLFKKNMKEIESFTHFVMLERKEKLEKIEAMRESDFQDDEIKMSRT DTTLMNLLLRAHLQDNKYTEEDVKKDIDT SLLQGSDATLSVVTWSIYMLGLHPKTQAKVHRELDAIFGTDTNRCVTSDDLKR MKYLECCLKETMRLYPPVPIVGRVLEHDQVIDNQTVPKGVQFFINVFRLHRNPKYFSDPERYLPERFMREETTFRPPFVY IPFSRGARKCL >&P450_Is170, VBpre_P001425 66% to P450_Is262 TDGHVVPKGVTCMVNIYTLQRNPKAFHKPEEFIPERFGSEEYSNRHPYSYIPFSGGPKNCLGKLMWLVYFSPTYTH >&P450_Is269, 26843.m000012 LFHLLVGMTHYFERERIFKAYLGFQPVVVLFKPESVEAVLNCSTNLKKPILYSLLHAWLGKGLLT >P450_Is147, VBpre_P013765 same as P450_Is269 MFAIVTSTFSAVFSATSALSLRYVMVMTITVATQRLLLCALLAVACAYA VQVVARFYRMWKAVRPMAGPSDWFPPLFNIHCLITGAAMKNVFSTSTG LFHLLVGMTHYFERERIFKAYLGFQPVVVLFKPESVEAVLNCSTNLKKPILYSLLHAWLGKGLLT SSGSKWRSRRKMLTPAFHFRILEDFLPIMNEQGEIFARALQGHTHAVFDITKFVTACTLDIIC >&P450_Is255, 21182.m000018 MLAALAQPEERAQKWAIQYAADTLAQQGLDG AGYQIPPGTTLALFMYTLHRDERWFPEPEEFRPERFFPENSVGRPAYAY VPFSAGPRNCIGQRFAMMEEKVVISTILRHFRLHSPDERDTVLITWELVLKPLNALNVHFMPKMKL >P450_Is007, VBpre_P012142 Same as P450_Is255 ELDAIFGEDRTRPATEEDLKQMKYLECVIKQLLTVSGPQPVSRHSRRQNT AGYQIPPGTTLALFMYTLHRDERWFPEPEE FRPERFFPENSVGRPAYAYVPFSAGPRNCIGQRFAMMEEKVVISTILRHFRLHSPDERDTVLITWELVLKPLNALNVHFM PKMKL >&P450_Is102, VBpre_P010604 N-term 42% to CYP4C3 SLTLLLSCIVPVAVHIARRRRIAELISKIPGPTAAHPILGNLDQNPDGNQLLRKVFFLQLVR >&P450_Is325 33428.m000008 TLQSTETIQKSGSEEEEFHSGGETSLMNRLLQKHIEDSSYTLSDVRNDIDTIIAAGNDTTTTCMCWTLQYLGLYSEVQAK VHRELDEVFGNDRDGEITAIHLAQLKYLECCLKEALRLYPSFPMIGRVLDEELQI Mito clan (12 sequence pieces, 6 different non-overlapping sequences, some will join) >&P450_Is311, 35614.m000014 CYP315A1 ortholog, 54% to CYP315A1 mite, 35% to CYP315A1 Aedes MSTAALAKRLARQLAAGVTSASGGTRRRMRSTEAASACPFHARWAADADKTGGRPVPKAAGGKPYSSIPAPRGLPLLGTA LDVALAGGAPKIHEYCDRRHRELGPIYKETLGSVEAVFVADSALIQQVYASEGKFPMHMVPEAWLIYNEVKGIQRGLFFM DGPEWIERRRSLNNVFLKPKTVTDHVPVFNDVIADLLDRWQETRDHSGVLENLERELYNWSIESLGTMIFGRRLGCIASS SSMENVHEFVHCVQQIFNESAKMSMMSPRVAYKLGLPVWKRFVKAAGRALELARDYVEENVRNIASGTSAGQSHQGILSQ LLLGERISEEELVRIVTDLFLAAADTTSHATQWAFYLLAKNPERQERLLEEVQSVVPHNQHVDEDCLARLPYVKAVIREA LRLYPVAPFLTRILSEDIVLNGYTVPAGKLILMSLYTTGRDERQFTEPNEFRPERWLRHGDRASQSSNSWACLPFGLGAR SCIGRRVAEVQMQSLIARTVQKFHLSPITDRDIPIKMRLITTPEEPVSLRLTPREGTV >P450_Is071, VBpre_P008386 same as P450_Is311 YVLSLKTNR DGPEWIERRRSLNNVFLKPKTVTDHVPVFNDVIADLLDRWQETRDHSGVLENLERELYNWSIESLGTMIFG RRLGCIASSSSMENVHEFVHCVQQIFNESAKMSMMSPRVAYKLGLPVWKRFVKAAGRALELARDYVEENVRNIASGTSAG QSHQGILSQLLLGERISEEELVRIVTDLFLAAADTTSHATQWAFYLLAKNPERQERLLEEVQSVVPHNQHVDEDCLARLP YVKAVIREALRLYPVAPFLTRILSEDIVLNGYTVPAGKLILMSLYTTGRDERQFTEPNEFRPERWLRHGDRASQSSNSWA CLPFGLGARSCIGRRVAEVQMQSLIARTVQKFHLSPITDRDIPIKMRLITTPEEPVSLRLTPREGTV >P450_Is072, VBpre_P008387 same as P450_Is311 ADKTGGRPVPKAAGGKPYSSIPAPRGLPLLGTALDVALAGGAPKIHEYCDRRHRELGPIYKETLGSVEAVFVADSALIQQ VYASEGKFPMHM SRPLLL >&P450_Is024, VBpre_P011038 90% to P450_Is278 33% to CYP301A1 same as EW788012, EW834609, EW808949 1 aa diff to EW801356, EW876128, EW787696, EW944377, EW961440 red seq from EST EW909080 MKAARVLLQGSRRAAHLGPAAAPAADGTHGESRVAAKPFGQMPRVPSFPLVGSSWIYWPLVGKYHPDRRHEAALDMHR QYGPIVAEKLPGRYSLVHLFSADDFHALYQHEGKTPFRMGATAFKKYRSSRPKYYKNIGILNMQGQEWYNVRSKTQPYTL RPRTIMSYVPGMDKIAEDTLQVLARDRDARGETADCYKLLYKWALESVVYASLDTRVGCLSVPLDPHSDGAMILKDMDDV FACLQIFGYRFPYFRYFRTPSWKRFEFAMDDFTIRLFKHIEAAAERLKTRTEDREYTILEYLLAEKKLEFGEILAFMSDF ILGGADTTSATATFCLYHLARNPEAQERARQEVFDVVGNKPRALEPEHLSHLPFLKACVKEALRLNPTLSGVFRKLDHDV TLSGYLVPAGTPLFTENYVASRLEENFTRADQFLPERWLKRDDEGRQDWALHPFASLPFSFGPRMCLGRRMAELEVWIML VKLLLKYRIEYHYEDIGVQGKLANAPDKPARYRFVDLH* >&P450_Is150, VBpre_P013787 100% to P450_Is024 C-term 86% to P450_Is278, C-term with a fusion to another gene RLEENFTRADQFLPERWLKRDDEGRQDWALHPFASLPFSFGPRMCLGRRMAELEVWIMLVK This part is not a P450 sequence DKQPMWKTYIMAAMFISLF AVSAFSAPPCSSASASYPELIPVFRMYQDAAQRMSSKHFLDDTSLSQLNNLHRTPQATSTVMEDRTRSWLNAQPVPMQGR PSCNSSLGILSDTVFSGTASTFTGESLKDNLPAKDKPSEEPGVSFCHPFADKSSFSVGEFYAGKSETAEEASEESLEGQP WKQDVTRPSWLPNAQERVSISSYFKARSAPIEGLPCAVEEKGTEKKWEVASSLTHAASSQLEANKSNAVAAPAAAEPGFE TFTAQSLEEMAVQELGLGTPRVAVPDGSVQGPSTSAIYHVLEDISISESPSAMVRKFIHATRSQKPPPRADLQERNEFSG DATFKQPLTAAPRSKKAAASRDGRAEAEEAPSEPASARQGLAACGPCALRSADGLCRTDPSTSKVWRRMRRRWQTHRRMR SSRRRGRFKGGGLVELGAVRRRRRQRPLLGAFIWLLRASDAIRFQEVPGVPATA >&EW951253.1 83% to P450_Is024 AFKKYRSSRPEYYKNIGILNMQGQEWYNLRSKTQPYTLRLRTIMSYVPGLDKIAEDTLKVLAHNIDARGETPDCYALLYRWAQESVMFASLDTRIGFLSVPLDPLSDGAMILRDMNDAFACLQIFGYRFPYFRYLRTPTWKRFERAMDDFSVRLFRHIEAAAERLQTRTEDREYTILEYLLAEKKLEFGEILAFMSDFVLGGADTTSSTVTFCLYHLGRNPEAQNRARREVFDVVGSESRTLEPEHLNQLPFLK & XCVKESLRSPNLS & GVSKLD & HDVT >&P450_Is278, 26540.m000014 91% to P450_Is024 TPLFTENYVAS RLEENFTRAEEFLPERWLKRDDQGRQDWV LHPFASLPFSFGARMCLGRRLAELEIWIVLVK >P450_Is180, VBpre_P005119 Same as P450_Is278 yellow may be wrong frame GACPFPDGALMPCS LNPTLSGVFRKLDHDVTLSGYLVPAG TPLFTENYVASRLEENFTRAEEFLPERWLKRDDQGRQDWV >&EW902122.1, EW900269.1 2 aa diffs to P450_Is163 37% to CYP302A1 Drosophila melanogaster 40% to CYP302A1 honeybee DMEQVFRNEGRYPARLSHRALLKYRSNRPQQYRGRGLFPSNGEEWSRLRHTFQKPLMQQNSMAVYMPVLQDVT WDVANLIRKTRHRTSLEMRDFLTELYRWALECTGVLALNTRLGCLEGKLSLDSEQQRLVE AASETHRIIMLTENG LPFWKFWDTPAYKRLVKSQDFMAGIVNKYLGQAKEKVRTDIPEEKKTVLEKFLSNPETDIKGVFTMILDMFLAGIDTTAYTTSFILYYLATNPSSQEKLFLELRRLLPEKDSQLDLEQLQNASYLKACIRESLRLSPIAIGVGRILPEDVVLSGYNVPAGTVLITHNQVACRQASNYPEPESFSPERWLKDRSDQGSTAKTHPFCLLPFGYGPRMCIGKRFAETVMCLLVARI VRNFELEYKYEKIDCFTRLINVPDKPLKMVFVDRSN* >P450_Is163, VBpre_P002865 46% to P450_Is024 2 aa diffs to EST EW902122 WSFDVLVLFFFQTAYTTSFILYYLATNPSSQEKLFLELRRLLPEKDSQLNLEQLQNASYLKACIRESLRLSPIAIGVGRI LPEDVVLSGYNVPAGTVLITHNQVACRQASNYPEPESFLPERWLKDRSDQGSTAKTHPFCLLPFGYGPRMCIGKRFAETV MCLLVARIVRNFELEYKYEKIDCFTRLINVPDKPLKMVFVDRSN >&P450_Is289, 35464.m000094 32% to CYP314A1 Apis, 34% to CYP314A1 Aedes, 33% to CYP302A1 mite, best match to mite CYP302 44% to CYP314A1 mite seq gap after AAAKV MKQGARVLARSVGSETPSIIALGHAEATPAAKQAQRRVVTPLADARTYPKPFHQIPGPKPSLPLIGTSWQYFRWGRYSLY QLHEACADKYRRYGDVMKEEYQWQVPIVHAFNPEDFETIFRHQGRCPIRPANEFVRKYRTEHPHKYSNVGLSNALGEEWH TLRTALAPVLLQMRSVPGLAAQQSEICEDFVSYVRFVRNSKSQAVDNIQDSLYRLALESIFMLCLDTRLGCLSRTVNYDS DAAIVITAAKDLFSAYQKLYYGLPLWKFFSTSAYRSYQRAEETLYELTLSYLQKYANHDCKDSAHAPYAKHTSLLHALLN TEGLSEKDVHLTIMDFIAGGVFTTTNALCFLLHHLACNPSIQEKLHGELQASNGDVSGCSYLRACMKESFRLNPTVPGVM RILPEDVVLSGYHVPAGVPVFANSLVTCHLEKYFAEPEAFRPERWLGAERTQIHPFSLLPFGHGARMCAGRRFAELELMT AAAKV VQNFVVETLLAHAQHELRVCGRP >P450_Is019, VBpre_P000039 Same as P450_Is289 MKQGARVLARSVGSETPSIIALGHAEATPAAKQAQRRVVTPLADARTYPKPFHQIPGPKPSLPLIGTSWQYFRWGRYSLY QLHEACADKYRRYGDVMKEEYQWQVPIVHAFNPEDFETIFRHQGRCPIRPANEFVRKYRTEHPHKYSNVGLSNALGEEWH TLRTALAPVLLQMRSVPGLAAQQSEICEDFVSYVRFVRNSKSQAVDNIQDSLYRLALESIFMLCLDTRLGCLSRTVNYDS DAAIVITAAKDLFSAYQKLYYGLPLWKFFSTSAYRSYQRAEETLYELTLSYLQKYANHDCKDSAHAPYAKHTSLLHALLN TEGLSEKDVHLTIMDFIAGGVFTTTNALCFLLHHLACNPSIQEKLHGELQASNGDVSGCSYLRACMKESFRLNPTVPGVM RILPEDVVLSGYHVPAGVPVFANSLVTCHLEKYFAEPEAFRPERWLGAERTQIHPFSLLPFGHGARMCAGRRFAELELMT AAAKV CLHTQI CYP20 clan (3 sequence pieces plus 2 ESTs, 1 gene) >CYP20 P450_Is314, 34501.m000073 33% to CYP20A1 human, N-term from EST MLEFAIFAVCFVVFLLMLVVYLYPGSSKQTTIPGIDPSDPKEGNVGDIVQAGGLKNFLLSLHKDHGPITSFWMGTKLVIS IGDAELFKTQTHIFDKPADLFELYRDLVGADSILFANGAEARQRRRRLDDVLTGDRINDFVGPLQK MCAEVVDRWESLPAEEHVPIYQYMYALCMKTCTRLLFGDYFFDDKHVLEFSRAFELCVKELEEMAGGMVPDPDSPRTKKY EEAAKKLRSLLKQALENSSRSQKGSGPKTLADVLSDGSVSDKVALDDCVTFALKSYSLVSAMTWALYFLATHPDVQDTIA KEADKLMSKEAPLKLQDFMQL SNLQKTIKETLRTATVEPWTARCQDVDVEIAGHVIPKK TPVIQALGVVLHEEDHWKVPH RFDSSRFNEKFPELAYCPFGFAGMRLCPGKDLSVLHMSVFLVTLCHRLKLRLIQDQVVTPTFALITKTDDEVWLTLERRRP >P450_Is053, VBpre_P011696 gray = same as P450_Is314 MLEFAIFAVCFVVFLLMLVVYLYPGSSKQTTIPGIDPSDPKEGNVGDIVQAGGLKNFLLSLHKDHGPITSFWMGTKLVIS IGDAELFKTQTHIFDKPADLFELYRDLVGADSILFANGAEARQRRRRLDDVLTGDRINDFVGPLQK MCAEVVDRWESLPAEEHVPIYQYMYALCMKTCTRLLFGDYFFDDKHVLEFSRAFELCVKELEEMAGGMVPDPDSPRTK KYEE GAQNALYL >P450_Is052, VBpre_P011693 gray = same as P450_Is314 red seq is probably wrong FC SNLQKTIKETLRTATVEPWTARCQDVDVEIAGHVIPKK 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