1073 sequences +
21 name change notices
note a few (~8)
are alleles or different gene models
of the same
gene. About 1065 different sequences.
Now 1423 CYP
entries Jan. 22, 2009 (added A. niger)
29 of these are
alleles (v2) or name changes and do not
contribute to
the sequence count, which leaves 1394.
Added 78 from Mycosphaerella graminicola now 1472
On 1/28/09 10AM count is 1680
After much
manual annoation of P450s from the Fungal genome database
I have 2003
named P450 sequences in this set. 2/27/2009 DRN
CURRENTLY
(4/16/2009) THERE ARE 2582 NAMED FUNGAL P450 SEQUENCES
On Aug. 11 2009
after putting all these P450s into a speadsheet
There were 2527
named fungal P450s after excluding variants.
There are 164
pseudogenes.
>CYP51F1 Mgr032 Mycosphaerella graminicola
63% to CYP51F1 Aspergillus fumigatus
MGLLQEVLAQFDAQFGQTSLWKLVGLGFLAFSTLAILLNVLSQLLFRGKLSDPPLVFHWVPFIGSTITYGIDPYKFFFSCREKYGDVFTFILLGKKTTVCLGTKGNDFILNGKLKDVNAEEIYSPLTTPVFGKDVVYDCPNSKLMEQKKFVKYGLTTSALQSYVTLIAAETRQFFDRNNPHKKFASTSGTIDLPPALAELTIYTASRSLQGKEVREGFDSSFADLYHYLDMGFTPINFMLPWAPLPQNRRRDYAQKKMSETYMSIIQKRRESKTGEHEEDMIHNLMQCKYKDGNAIPDKEIAHMMIALLMAGQHSSSATESWITLRLASRPDIQDELLQEQKDMLGVNADGSIKELTYANLSKLTLLNQVVKETLRIHAPIHSILRKVKSPMPIEGTAYVIPTTHTLLAAPGTTSRMDEHFPDCLHWEPHRWDESPSEKYKHLSPTTALGSIAEEKEDYGYGLVSKGAASPYLPFGAGRHRCIGEQFAYVQLQTITATMVRDFKFYNVDGSDNVVGTDYSSLFSRPLSPAVVKWERREEKEEKN
>CYP51F1 Mycosphaerella fijiensis
e_gw1.3.1317.1
81% to CYP51F1 Mycosphaerella
graminicola
MGLLQDAAALFDAQFGQTATWKLVPLGFSIFFAVSVLLNVLRQLLFRNPNEPPLVFHYVPFIGSTISYGIDPYKFFFACR
QKYGDCFTFILLGKKTTVVLGTKGNVFILNGKLKDVNAEEIYSPLTTPVFGTDVVYDCPNSKLMEQKKFVKYGLTSSALQ
SYVKLITKETKDFFSKDNPSKKFASTHGTVDLPPAMAELTIYTASRSLQGKEVREKFDSSFADLYHDLDMGFTPINFMLP
WAPLPQNRARDRAQKKMAEVYTAIIKERREKGEPTSGEKEQDMIWNLMQCQYKNGQAIPDKEIAHMMIALLMAGQHSSSS
TSCWILLRLASRPDIQDELLQEQKDVLGVNADGSIKELTYADISRLPLLNQVVKETLRLHAPIHSILRQVKSPMPLEGTP
YVVPTTHSLLAAPGATSRMDEHFPEAMLWEPHRWDENPSEKYAHLAPKHVKEGVAEETEDYGYGLVSKGAASPYLPFGAG
RHRCIGEQFAYVQLQTITSEVIRDFKLYNVDGSDKVVGTDYSSLFSRPLSPAVVRWERREKK*
>CYP51F1 Erysiphe graminis f. sp. hordei
AF052515
MGISESFMFPYLQPLLQLGFGIALASGILSLLLLLTFLNVLKQL
LFKNPNEPPIVFHWIPIIGSTISYGMNPYKFFHESQAKYGNIFTFILLGKKTTVYLGR
QGNNFILNGKLRDVNAEEIYTVLTTPVFGTDVVYDCPNSKLMEQKKFMKAALTTEAFR
SYVPIIQNEVKSFIEKCDDFRKSKGIINIDAVMAEITIYTASHTLQGKEVRDRFDSSL
AVLYHDLDMGFTPINFMLHWAPLPHNRARDHAQRTVAKIYMEIINSRRTQKETDDSNL
DIMWQLMRSSYKDGTPLPDKEIAHMMIALLMAGQHSSSSSSTWIMLWLAARPDITEEL
YQEQLELLGSELPPLKYEDLSKLSLHQNVLKEVLRLHAPIHSILRKVKNPMPVPGTSY
VIPKTHSLLAAPGWTSRDASYFPNPLKWDPHRWDTGSGGVIGTDMEDEKFDYGYGLIS
TGAASPYLPFGAGRHRCIGEQFATVQLVTIMATMVRSFKHNLDGRNSVAETDYSSMF
SRPMQPATIAWEKR
>CYP51F1 Uncinocarpus reesii
78% to CYP51F1 Ajellomyces capsulatus
UREG_07804.1
MGVLADLFAGARQACSTQPLWTLALLGLGAFITLSVVVNVLNQILFKNPNEPPVVFHWFPVIGSTITYGIDPYNFFFSCR
EKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLKDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKFGLTSEALR
SYVTLITREVEQYLENSPAFKGDSGILSVAKVVAEITIYTASRSLQGKEVRDKFDSSFAELYGDLDMGFAAINFMFPWAP
LPHNRKRDRAQQKMAQIYTDIIRERRAAGGEKDSEDMVWNLMSSVYKDGTPVPDIEVAHMMIALLMAGQHSSSSTGSWIV
LRLASRPDILEELYEEQLRVLGPDLPPLTYESLQRLELHSNVIKETLRIHAPIHSILRAVKSPMPVDGTKYVIPTTHNLL
AAPGVASRLPDYFPDPMLWNPHRWEKGGAVNTTGVLDEGAEEKIDYGYGLVSKGANSPYLPFGSGRHRCIGEQFAYVQLG
TITAALVRALKLKKLDGDKEIPNTDYSVSRKGICH
>CYP51F1 Coccidioides immitis
89% to CYP51F1 Uncinocarpus
reesii
CIMG_07469.2
MGLLANVLTGVSKACSGQSPWTLVLLGICAFLTLSVFVNVLKQVFFKNPNEPPVVFHWFPIIGSTISYGIDPYKFFFSCQ
KKYGDIFTFILLGKKTTVFLGTKGNDFILNGKLKDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKFGLTSEALR
SYVTLITREVESYLENSPAFQGDSGVFNVAKSVAEITIYTASRSLQGKEVRDKFDSSFAELYADLDMGFAAINFMFPWAP
LPHNRKRDRAQQKMTQVYTDIIRERRKAGGKKDSEDMVWNLMSSVYKDGTPVPDVEVAHMMIALLMAGQHSSASTGSWIV
LRLASRPDILEELYQEQLRVLGPDLPPLTYESLQRLELHSNVIKETLRLHAPIHSILRAVKSPMPVDGTKYVVPTSHNLL
AAPGVPSRMADYFPEPMLWDPHRWEKGGGVNATGVQDEAAEEKVDYGYGLVSKGANSPYLPFGSGRHRCIGEQFAYVQLG
TITAALVRALKLRKLDGDKEVPDTDYSSLFSKPLGNPKVAWEKRKPSSKQ
>CYP51F1 Debaryomyces hansenii
75% to CYP51F1 Candida guilliermondii
CAG88416.1
MALADYSIALYNYFTSLAIVQQASIIILFPFIYNLLWQFFYSFRKDRVPLVFHWMPWVGSAVVYGMQPYEFFENCRTKYG
DVFAFVLLGKVMTVYLGPKGHEFVLNSKLQDVSAEEAYTHLTTPVFGKGVIYDCSNSRLMEQKKFAKYALTKDSFRKYVP
KIKEEVLSYFTDSENFNMKGKSSGVVNVMESQPEITIFTASRSLMGDEMRKKFDASFAQLYTDLDKGFTPINFVFPHLPL
PQYRKRDAAQQKISSTYMSLISKRRDTGDIDPSRDLIDSLMTHSTYKDGVRMTDQEIANLLIGVLMGGQHTSASTSAWFL
LHLAENPSLQDEVYEEILSVLKQKNGSFNDLDYDDLQNMPLLNNIIKETLRMHMPLHSIFRKVKNPLLVPNTQYVVPKGH
HVLVSPGYAMTNEKWFPEAAKFKPHRWDETAKATGNEDTVDYGFGAITKGVASPYLPFGGGRHRCIGEQFAYVQLGTILS
TYVYNMKWSLKDGKMPEIDYASMVTLPMEPADICWEKRENCVI
>CYP51F1
Pichia anomala AF019903
EFVKGALTRDAFKSYVPQIREEIIHYFQNSKNFKFGERKHGISN
VMATQPEITIFTASRSLMGKQMRERFDESFAGYYSDLDKGFTPINFVFPNLPLPSYRR
RDYAQQKISSTYMGLIKERRENNDIKDRDLIDTLMKTSTYKDGVKMTDQEIANLLIGV
LMGGQHTSAATSAWFLLHLAEKPELQEEIYQEIMKVTGGEDVTYDDLQEMPLVNNVIK
ETLRMHMPLHSIFRKVKNPLPVPGTSYVVPKGHHVLVSPGFAMTNENYFPQPEVYNPH
RWDEDSTSKAAQDSSTVDYGFGAVSKGVSSPYLP
>CYP51F1 Pichia stipitis
71% TO CYP51F1 Debaryomyces hansenii
JGI model e_gww1.7.1.351.1
MALLDSAIVAYNYFVSLSLTQQVLIIVFAPFIYNIVWQFLYSLRRDRAPLVFHWIPWFGSAIPFGMAPYKFFEDSRQKYG
DVFAFMLLGRTMTVYLGPKGHEFVFNSKLNETNAEDAYKHLTTPVFGKGVIYDCPNHRLMEQKKFAKYALTRDAFKTYVP
KIREEIISYFKNPEGFNMGEKNSGVANIMKTQPELTIFTASRSLLGDDMRKRFDASFAQLFSDLDKGFTPLNFVFTNLPL
PNYRKRDNAQQKISATYKSLIEKRRATGDVDPNRDLIDSLMTYSTYKDGVKMTDQEIANLLIGILMGGQHTSAATSAWFL
LHLGARPDLQDELFEEVSNILKEKGTSNLNDLSYEDLQNMTLTNNVIKETLRLHMPLHSIFRKVSKLLLVPNTNYTVPAG
HYVLVSPGYTQTSDRFFPNASTFDPHRWDSNNLADKNADEGTVDYGFGAVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGT
ILSAFVYNVKWSLKGEKVPANDFTSMVVLPEEPAEIIWEKRKTCTF
>CYP51F1 Aspergillus fumigatus
GenEMBL
AAK73660.1 also XP_749134.1, EAL87096.1
14-alpha
sterol demethylase
79% to 51F1
A. nidulans
MGLIAFILDGICKHCSTQSTWVLVGIGLLSILAVSVIINVLQQLLFKNPHEPPVVFHWFPFIGSTISYGI
DPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPN
AKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEV
RSKFDSTFAELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWN
LMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTY
DNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWN
PHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLP
GVDGIPDTDYSSLFSKPLGRSFVEFEKRESATKA
>CYP51F1 Aspergillus oryzae
GenEMBL BAE60239.1
79% to CYP51F1
Aspergillus nidulans, 60% to CYP51F4
MGILAVILDSVCERCSGSSLWMLSTVALLSILVVSVVINVLRQLLFKNYKEPPLVFHWFPFIGSTISYGM
DPYRFFFNCREKYGDIFTFVLLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPN
AKLMEQKKFVKFGLTSDALRSYVRLITEEVEDFVQKSSALQGPNGVFDVCKTIAEITIYTASRSLQGKEV
RSRFDSTFAELYHDLDMGFAPINFMLPWAPLPHNRKRDAAQKRMTETYMEIIKERRKAGSKKDSEDMVWN
LMSCMYKDGTPVPDEEIAHMMIALLMAGQHSSSSTAAWIVLHLAASPEITEELYQEQLRILGHDMPPLTY
ENLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVEGTPYVIPTSHNVLSSPGVTARSEEHFPDPLEWK
PHRWDEAIAVSSEDEEKVDYGYGLVTKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAALVRLFKFSNLP
GVQTLPDTDYSSLFSKPLGNSKIQFEKREPVTKA
>CYP51F1 Aspergillus flavus
100% to CYP51F1 Aspergillus oryzae
AFL2G_06478
MGILAVILDSVCERCSGSSLWMLSTVALLSILVVSVVINVLRQLLFKNYKEPPLVFHWFPFIGSTISYGMDPYRFFFNCR
EKYGDIFTFVLLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKFGLTSDALR
SYVRLITEEVEDFVQKSSALQGPNGVFDVCKTIAEITIYTASRSLQGKEVRSRFDSTFAELYHDLDMGFAPINFMLPWAP
LPHNRKRDAAQKRMTETYMEIIKERRKAGSKKDSEDMVWNLMSCMYKDGTPVPDEEIAHMMIALLMAGQHSSSSTAAWIV
LHLAASPEITEELYQEQLRILGHDMPPLTYENLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVEGTPYVIPTSHNVL
SSPGVTARSEEHFPDPLEWKPHRWDEAIAVSSEDEEKVDYGYGLVTKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAAL
VRLFKFSNLPGVQTLPDTDYSSLFSKPLGNSKIQFEKREPVTKA*
>CYP51F1 Aspergillus niger
estExt_fgenesh1_pm.C_150008|Aspni1
84% to CYP51F1
MGLLAVVLDSLCERCSNTSVLVVLGFGLLSLLAVSVIFNILRQLFFKNPNEPPLVFHWFPFIGSTISYGMDPYKFFFDCR
AKYGDIFTFILLGKKTTVYLGTRGNDFILNGKLRDVCAEEVYSPLTTPVFGRNVVYDCPNAKLMEQKKFVKFGLTSDALR
SYVRLITGEVENFVEHSAAFKGSSGVFDVCKTIAEITIYTASRSLQGKEVRSRFDSTFAELYHDLDMGFAPINFMLPWAP
LPHNRKRDAAQKKMTETYMEIIKERRNGGNKKDSEDMVWNLMSCIYKDGTPVPDEEIAHMMIALLMAGQHSSSSTASWIV
LHLARNPQIMEELYAEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVDGTPYVIPTSHNVL
SSPGVTARSEEYFPNPLKWDPHRWDETIAASAEEEDQIDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAAL
VRLFKFRNLPNVKDIPETDYSSLFSKPAGKSIIQFEKRATTIKS*
>CYP51F1 Aspergillus clavatus NRRL 1
XM_001273213.1, ACLA_005420
89% to 51F1 S.
fumigatus
61% to 51F2 A.
fumigatus
MGLITDILDGVCKYCSTQSIWMLGGVGLLSLLAVAVVVNVLRQL
LFKNPNEPPLVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGT
KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKFGLTSDALR
SYVHLITDELESFVKSSSAFQGPKGVFDVCKTIAEITIYTASRSLQGKEVRNKFDSTF
AELYHDLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGNEKDSED
MVWNLMSCVYKNGVPVPDEEIAHMMIALLMAGQHSSSSTAAWIVLRLATRPDIMEELY
QEQLRVLGSDLPPLTYDSLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMPVEGTPYV
IPTSHNVLSSPGVTARSEEHFADPLEWNPHRWDEHIVENDEDEEKIDYGYGLVNKGTN
SPYLPFGAGRHRCIGEQFAYVQLGTITAGLARLFKFRNLPDIEGIPDTDYSSLFSKPL
GKSVVQFEKREPALKA
>CYP51F1 Aspergillus terreus NIH2624
XM_001212028.1
ATEG_02850.1
MGVFADIIGTLCEHCSTLSIWALGGAVLLAVFVLSVVINVLRQL
LFKNPHEPPVVFHWVPWIGSTIRYGIDPYKFFFECR AKYGDIFTFVLLGKKTTVYLGT
KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQ KKFVKFGLTSDALR
SYARLITAEVDDFVKNSPTFQQPKGTFDVCKTIAEITIYTASRSLQGKEVRNRFDSTF
AEMYHDLDMGFAPINFVLPWAPLPHNRKRDAAQKKMAETYMEIIKER
RQAGGKKDSED
MVWNLMSCVYKDGTP LPDEEIAHMMIALLMAGQHSSSSTASWIVLRLAENPEITEELY
QEQLRVLGSDLPPLTWDSLQKLDLHAKVIKETLRIHAPIHSIMRAVKNPMPVEGTPYV
IPTSHNVLSSPGVTARSEEYFSEPLKWDPHRWDETAAPSTEEEEETIDYGYGLVTKGT
NSPYLPFGAGRHRCIGEQFAYVQLGAITAALVRLFKFSNPPGANKLPDTDYSSLFSKP
LGKSYVQFEKRETNTKA
>CYP51F1P Aspergillus terreus
71% to CYP51F1
Aspergillus terreus
ATEG_10302.1 revised
MGLFAAALDKICKQCSTQAIYMLSGVGVITTLVLSVVINVLIQLSFKNPNEPPVVFHWFPLIGSTISYGTDPYKFFFECRRK
(0)
YGDIFTFILLGKKTTVFLGTKGNDFVLNAKLHDLCAE*VYSSLTTPVFGNHVVYDCPNFKPMKQKK
(0)
FVKFGLASDALRSYVELITKEVDEYITNANAFKQPRGTIDVGKVIADITIYTASRLLQGKEVREKFDSTFAELYHDLD
MGFAPINFILPWAPLPHNCKRDAAQKKMAQTYMEIIQKRR
*SGGEKNSEDMVWNLMSCVY
KDGTPVPDIEVAHIMIALLMAGQHSSSSTISWIILRLASQPEITEQ
LYQEQIRVLGADLPPLTYENLQKLELQTNVIKETLRLHAPIHSMLRTVKYPLQVEGTSYVIPNSHNVLSSPGFTA*SPE
YFSKPLDWEPHRWNGVNATG
DDEQVDYGYGLVSKGAGSPYLPSGAGRHRCIGEQFAYVQLCAICVALVRELKFKKLPNVEDVPATNYSSLFSRP
WANSVVQYERRDAAAKD
>CYP51F1 Neosartorya fischeri NRRL 181
XM_001261294.1, NFIA_024690
98% to CYP51F1 A.
fumigatus = ortholog
63% to CYP51F2 A.
fumigatus
MGLIAFILDGICKHCSTQSTWVLVGVGLLSILAVSVIANVLQQL
LFKNPHEPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGT
KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALR
SYVPLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTF
AELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQTGSKKDSED
MVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELY
QEQIRVLGSDLPPLTFDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYV
IPTSHNVLSSPGVTARSEEHFPNPLEWDPHRWDEDIAASAEDDEKVDYGYGLVNKGTN
SPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFKFRNLPGVDGVPDTDYSSLFSKPL
GRSFVEFEKRESATKA
>CYP51F1 Ajellomyces capsulatus NAm1
XM_001540158.1
63% to CYP51F2 A.
fumigatus
74% to CYP51F1 A.
fumigatus
MGLLADVVARVCAHCSTLSPWAFLLTGSATLIVLSVIINVLHQL
LWKNPNEPPVVFHWFPIIGSTISYGIDPYKFFLNCREKYGDIFTFVLLGKKTTVFLGT
KGNDFILNGKLKDVCAEEVYSPLTTPVFGSHVVYDCPNSKLMEQKKFVKYGLTSESLR
SYVTLITDEFNQYIKTSPAFQGDKGVLDVCKSIAEITIYTASRSLQGKEVRSKFDSSF
AQLYHDLDMGFTPINFMLPWAPLPHNRKRDAAQQKMTKIYTDIIRQRREAGGKKDSED
MVWNLMSCVYKDGTPLPDIEIAHMMIALLMAGQHSSSSTFSWIILRLASCPHIIEELY
EEQKQVLGEDLPPLTYETLQKLNLNSHVIRETLRIHAPIHSILRAVKSPMPVDGTRYT
IPTTHNLLAAPGVTSRLPEHFPNPMTWDPHRWENPAMAPEGDQSDEKLDYGYGLVSKG
ANSPYLPFGSGRHRCIGEQFAYVQLGTLLVAIVRQLKLKKLDGETGVPATDYSSLFSK
PLGKPLVAWERRNPTQK
>CYP51F1 Histoplasma capsulatum G217B,
teleomorph: Ajellomyces capsulatus
96% to CYP51F1 Ajellomyces capsulatus NAm1
HCB02684.1 model is a fushion protein, top
part deleted
MGLLADVVARVCAHCSTLSLWALLLAGSASFIVLSVIINVLHQLLWKNPNEPPVVFHWFPIIGSTISYGIDPYKFFLNCR
EKYGDIFTFVLLGKKTTVFLGTKGNDFILNGKLKDVCAEEVYSPLTTPVFGRHVVYDCPNSKLMEQKKFVKYGLTSESLR
SYVTLITDEFNQYIKTSPAFQGDKGVLDVCKSISEITIYTASRSLQGKEVRSKFDSSFAQLYHDLDMGFSPINFMLPWAP
LPHNRKRDAAQQKMTKIYTDIIRQRREAGGKKDSEDMVWNLMSCVYKDGTPLPDVEIAHMMIALLMAGQHSSSSTLSWII
LRLASCPHIIEELYEEQKQVLGEDLPPLTYETLQKLNLNSHVIRETLRIHAPIHSILRAVKSPMPVDGTRYTIPTTHNLL
AAPGVTSRLPEHFPNPMTWDPHRWENPAMAQEEDQSGEKLDYGYGLVSKGANSPYLPFGSGRHRCIGEQFAYVQLGTLLA
AIVRQLKLKKLDGETGVPATDYSPLGKPLVAWERRNPTQK
>CYP51F1 Venturia inaequalis strain Ent27
GenEMBL AF227920
14
alpha-demethylase
MGLLSPLLAXLPGSDRSWLFYTLASFGFTVAIVAANLVKQLLFS
NPNEPPVVFHWFPFFGNTVVYGIDPIKFFAECKEKHGDIFTFILLGRKTTVYIGTKGN
EFILNGKQSHVNAEEIYSPLTTPVFGSDVVYDCPNSKLMEQKKFVKYGLTTE
ALKSYV
TLIQQEVEDYTKRYPQFKGEKGSFDVCASMAEITIFTASRSLQGKEVRDKFDASFADL
FHDLDMGFSPINFMLPWAPLPHNRRRDAANKKMTETYLEIIQSRKAEGVKKDSEDMIW
NLMQCVYKNGTPIPDKEIAHMMIALLMAGQHSSSSTSSWILLRLATRPDIQEELYQEQ
IRVCGADLPPLQYEDLARMPLHNQIIKETLRMHSPIHSILRAVKQPMPVEGTPYTIPT
SHVLLAAPIASGGSPMYFPAPEKWEPHRWDEGSGGTNISGGENGGEEKEDYGYGLITK
GASSPYLPFGAGRHRCIGEQFAYMQLNTVLATQVREFKFSLREGESFPKTDFSSLFSG
PLRPAWLNWERREKSS
>CYP51F1
Issatchenkia orientalis S75391
MPWVGSAVVYGMQPYEFFENCRKQHGDVFSFLLLGKVMTVYLGP
KGHEFVLNAKLSDVSAEDAYTHLTTPVFGKGVIYDCPNWKLMEQKKFAKVALTKESFI
RYVPLIKDEMLKYFNANFRGDSGKTDVLKSQSEMTLFTASRSLFGDALRNRLDASYAE
MYSDLDKGFTPLNFVFSYLPLPNYWKRDAAHKNISNTYLDLINTKRAGGEIKNEDLVD
ALLKNSVYKDGTRMTDEELAHLMIGVLMGGQHTSSATSAWFLLHLGEKPQLQEEIYRE
IQSVLGENFERELTYDDLQKLDLVNATIKETLRLHMPLHSIFRKVTRDLPVPNTSYIV
PKGHYVLISPGYTMLSERYFPNASEFQPHRWDEIKSIDGGISFGAEGENAKETVDYGF
GKISKGVASPYLPFGGGRHRCT
>CYP51F1
Uncinula necator U72657
MYIADILSDLLTQQTTRYGWIFMVTSIAFSIILLAVGLNVLSQL
LFRRPYEPPVVFHWFPIIGSTISYGIDPYKFYFDCRAKYGDIFTFILLGKKVTVYLGL
QGNNFILNGKLKDVNAEEIYTNLTTPVFGRDVVYDCPNSKLMEQKKFMKTALTIEAFH
SYVTIIQNEVEAYINNCVSFQGESGTVNISKVMAEITIYTASHALQGEEVRENFDSSF
AALYHDLDMGFTPINFTFYWAPLPWNRARDHAQRTVARTYMNIIQARREEKRSGENKH
DIMWELMRSTYKDGTPVPDREIAHMMIALLMAGQHSSSSTSSWIMLWLAARPDIMEEL
YEEQLRIFGSEKPFPPLQYEDLSKLQLHQNVLKEVLRLHAPIHSIMRKVKNPMIVPGT
KYVIPTSHVLISSPGCTSQDATFFPDPLKWDPHRWDIGSGKVLGNDAVDEKYDYGYGL
TSTGASSPYLPFGAGRHRCIGEQFATLQLVTIMATMVRFFRFRNIDGKQGVVKTDYSS
LFSMPLGTPLIGWEKR
>CYP51F1 Lodderomyces elongisporus
77% to CYP51F1 Candida parapsilosis
LELG_03738
MALVDLAIQGYTFFMSLTTFQQVFILIVVPFVYNIAWQLLYSLRKDRVPLVFYWIPWFGSAVGYGQQPYEFFEQCRQKYG
DVFAFVLLGKVMTVYLGPKGHEFILNAKLSEVSAEEAYKHLTTPVFGKGVVYDCPNQRLMEQKKFAKFALTTDSFRKYVP
LIREEVLNYFTSNSNFNMKNQKSGVADVMKTQPEITIFTASRSLMGKEMRSRFDESFAELYSDLDKGFTPVNFVFPNLPL
PHYWKRDAAQQKISSTYMKEITKRRQAGAIDGDEDLISSLMVHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL
LHLGDKPELQEQLYEEIQQALQSKGGNLSDLSYEDLQKMTLVNNTIKETLRMHMPLHSIFRKVMSPMVVPGTTYVVPKGH
HVLVSPGYAHTNERYYKNANQFDPHRWDNANMSNKDSDEVDYGFGKVSKGVASSYLPFGGGRHRCIGEQFAYVQLGTLLT
TFIYNIKWKLKGGHVPHVDYASMVTLPELPAEIVWEKRDTCVV
>CYP51F1
Candida lusitaniae
72% to CYP51F1 Candida tropicalis
CLUG_04932.1
MALAEYVAWGYAQFCSLGLLSKIALLVFTPIVFNVLWQFVYSLRKDRVPMVFHWIPWFGSAIPYGMQPYEFFESCREKYG
DVFAFMLLGRVMTVYLGPKGHEFVLNSKLADVSAEEAYSHLTTPVFGKGVIYDCPNHRLMEQKKFAKFALTKDSFQKYVP
RIQEEILDYFKSCSDFSMTERNSGVANVMKTQPELTILTASKSLMGDDMRARFDTSFAQLYSDLDKGFTPINFVFPHLPL
PAYRRRDEAQRKISATYMSLINDRRKSGDIVPDRDLIDSLMLNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWFL
LHLAEKPELQEELYNEVLSVLTKKGGKITDLSYEDLQEMHLVNQTIKETLRLHMPLHSIFRKVKHNLVVPNTSYVVPKGH
HVLVSPGYAQTSERWFPKADTFDPHRWDNDWASSVSEGDAVDYGFGKITKGVSSPYLPFGGGRHRCIGEQFAYVQLGTIL
ATYVYNIKWHYAKGHSLPDVDYQSMVTLPMAPAEIVWEKRETCVI
>CYP51F1
Candida dublinensis
93% to CYP51F1 Candida
albicans, cdub_2-g61.1, GenEMBL AJ012573
MAIVETAIDGINYFLSLSVTQQITILLGVPFVYNLIWQYLYSLRKDRAPLVFYWIPWFGSAASFGQKPYEFFESCRQKHG
DIFSFMLLGKIMTVYLGPKGHEFIFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTESFKRYVP
KIREEILDYFVNDESFKLKEKNHGVANIMKTQPEITIFTASRSLFGDDVRKLFDRSFAQLYSDLDKGFTPINFVFPNLPL
PHYWRRDAAQKKISATYMKEIKLRRERGDIDPSRDLIDSLLTHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFL
LHLGEKPHLQDAIYQEVVELLKEKGGDLNDLTYEDLQKLPSVTNTIKETLRMHMPLHSIFRKVKNPLRIPETNYVVPRGH
YVLVSPGYAHTSERYFDNPNNFDPTRWDTAAAKANSVSFNSSDEVDYGFGKISKGVSSPYLPFGGGRHRCIGEQFAYVQL
GTILTTFVYNLRWTVEGNRVPDPDYSSMVVLPTEPARIIWEKRETCMF
>CYP51F1
Candida glabrata S75389
CAG58795.1
MSTENTSLVVELLEYVKLGLSYFQALPLAQRVSIMVALPFVYTITWQLLYSLRKDRPPL
VFYWIPWVGSAIPYGTKPYEFFEDCQKKYGDIFSFMLLGRIMTV
YLGPKGHEFIFNAKLADVSAEAAYSHLTTPVFGKGVIYDCPNHRLMEQKKFVKGALTK
EAFVRYVPLIAEEIYKYFRNSKNFKINENNSGIVDVMVSQPEMTIFTASRSLLGKEMR
DKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQQAISGTYMSLIKERREKN
DIQNRDLIDELMKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWCLLHLAERP
DVQEELYQEQMRVLNNDTKELTYDDLQNMPLLNQMIKETLRLHHPLHSLFRKVMRDVA
IPNTSYVVPRDYHVLVSPGYTHLQEEFFPKPNEFNIHRWDGDAASSSAAGGDEVDYGF
GAISKGVSSPYLPFGGGRHRCT
>CYP51F1
Candida parapsilosis
75% to CYP51F1 Candida
tropicalis
AF019902, CPAG_03310
MALVDLALHGYNYFMTLSTLQQFGLLVFAPFIYNIIWQLLYSLRKDRVPLVFYWIPWVGSAVSYGQDPYGFFEQCREKYG
DLFSFVMLGRVMTVYLGPKGHEFVFNAKLSDVSAEDAYQHLTTPVFGKGVIFDCPNARLMEQKKFAKTALTTDSFRRYVP
LIRGEILDYFTKSKVFNMKKQKSGVVDVLQSQPEITIFTASRSLLGEAMRKRFDASFAQLYADLDKGFTPINFVFPHLPL
PHYWKRDAAQQKISETYMTEIARRRETGDIDENRDLIDSLLVNSTYKDGVKMTDQEIANLLIGVLMGGQHTSATTSAWFL
LHLAEKPQLQDELYQEVLNALSGKGGNLDDLSYEDLQQMPLVNNTIKETLRLHMPLHSIFRKVVSPLVVPNTKYIVPRGH
HVLVSPGYAHTNERFYKDASDFNPHRWDESASTNDAGEVDYGFGKVSKGVSSSYLPFGGGRHRCIGEQFAYVQLGTILTT
FVYNLKWKLANGKVPDVDYTSMVTLPQHPAEIVWEKRDTCVI
>CYP51F1
Candida albicans X13296, orf19_922
MAIVETVIDGINYFLSLSVTQQISILLGVPFVYNLVWQYLYSLR
KDRAPLVFYWIPWFGSAASYGQQPYEFFESCRQKYGDVFSFMLLGKIMTVYLGPKGHE
FVFNAKLSDVSAEDAYKHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKRYVP
KIREEILNYFVTDESFKLKEKTHGVANVMKTQPEITIFTASRSLFGDEMRRIFDRSFA
QLYSDLDKGFTPINFVFPNLPLPHYWRRDAAQKKISATYMKEIKSRRERGDIDPNRDL
IDSLLIHSTYKDGVKMTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDVIY
QEVVELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSIFRKVTNPLRIPET
NYIVPKGHYVLVSPGYAHTSERYFDNPEDFDPTRWDTAAAKANSVSFNSSDEVDYGFG
KVSKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTFVYNLRWTIDGYKVPDPDYSSM
VVLPTEPAEIIWEKRETCMF
>CYP51F frag.
Candida guilliermondii X97680
this seq is 94% to
Candida albicans but only 66% to
full length
CYP51A1 for C. guilliermondii
This is a
different gene
MTDQEIANLLIVILMGGQHTS--TSAWFLLHLGEKPHLQDVIYQEV
VELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSTFRKVTNPLRSPNKYMS
SHTVYMFKFL
>CYP51F1
Candida guilliermondii
71% to CYP51F1 Candida
lusitaniae
PGUG_03415.1
MAIADIATWVYSEFRGLPVSAQISIVVLFPFVYNLLCQFWYSLQKDRAPLVFHWVPWLGSSVVYSMQPYEFFESCRQKYG
DVFSFVMVGRVMTVYLGPKGHEFVFNSKATDVSAEDAYTHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTKDSFIKYVP
KIQDEVLSYFVEHDFKMKEKDSGVVNVMKTQPEITIFTASRSLMGDEMRKRFDTSFAQLYSDLDKGFHPIHFAFPHLPLP
MSRNRDRAQQKISATYKGLIDTRRSSGNIDPTRDLIDSLMATSTYKDGVKMTDQEIANLLIGILMGGQHTSAATSAWFLL
HLGERPDLQEEMYKEICGVFEKKNKSFKDLSYDDLQEMPLVNNVIKETLRMHMPLHSIFRKVKKPLLVPGTKYTVPKGHY
VMVSPGYAMVNDRWFPDAASFNPRRWDEQPLPTDGQDETVDYGFGNISKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILA
SYVYNVTWELKDKLPGVDYASMVTLPLEPADIVWKKRRTCVF
>CYP51F1 S.
pombe Z54096
MAFSLVSILLSIALAWYVGYIINQLTSRNSKRPPIVFHWIPFVG
SAVAYGMDPYVFFRECRAKYGDVFTFVCMGRKMTAFLGVQGNDFLFNGKLADLNAEEA
YSHLTTPVFGKDVVYDIPNHVFMEHKKFIKSGLGFSQFRSYVPLILNEMDAFLSTSPD
FGPGKEGVADLLKTMPVMTIYTASRTLQGAEVRKGFDAGFADLYHDLDQGFSPVNFVF
PWLPLPRNRRRDRAHKIMQKTYLKIIKDRRSSTENPGTDMIWTLMSCKYRDGRPLKEH
EIAGMMIALLMAGQHTSAATIVWVLALLGSKPEIIEMLWEEQKRVVGENLELKFDQYK
DMPLLNYVIQETLRLHPPIHSHMRKVKRDLPVPGSKIVIPANNYLLAAPGLTATEEEY
FTHATDFDPKRWNDRVNEDENAEQIDYGYGLVTKGAASPYLPFGAGRHRCIGEQFAYM
HLSTIISKFVHDYTWTLIGKVPNVDYSSMVALPLGPVKIAWKRRN
>CYP51F1
Schizosachharomyces japonicus
78% to Schizosachharomyces pombe CYP51A1 SJAG_03750
MVVSMVSILLSVGLAWYVGYIANQIFNRDPKRPPVVFHWFPFIGSAVTYGIDPYVFFRQCRAKYGDVFTFVLMGRKITAY
LGVKGNDFLFNGKLADLSAEEAYSHLTTPVFGKDVVYDVPNHVLMEHKKFIKSGLGFDQFRAYVPLIVNEMHDFLAKAPT
WGPGKSGVADLLATMPVMTIYTASRTLQGEEVRAGFNAGFADLYHDLDQGFTPINFIFPWLPLPRNKRRDRAHNIMAETY
LNIIKKRRAAHENPGTDMIWTLMGSRYRDGRPLKDHEIANMMIALLMAGQHTSAATIMWILSLLGSKPEVIEMLYEEQKR
VFGKELRPLDFDSYKDLHLVNYVIREALRLHPPIHSIMRKVKRNLAVPGTKIVIPAGHHLLAAPGVTATDEEFFAHAKDF
DPERWNSRVNEDEGDVERVDYGYGLVTKGAASPFLPFGAGRHRCIGEQFATMHLCTLVSTFVREYKWTTVGGVPKVDYSS
MVALPLGPVKIAWERRE
>CYP51F1 Schizosachharomyces octosporus
SOCG_01956
MAISLLPLVLSGILAWYVGYILNQITNRNPKRPPIVFHWVPFFGSAIPYGIDPYAFFHECREKYGDVFTFVCMGRKMTAY
LGVKGNDFLFNGKLADLSAEEAYSHLTTPVFGKDVVYDVPNHVLMEHKKFIKSGLGFPQFRSYVPLILNEMDAFLNTSPE
FGPGKEGIADLLKTMPVMTIFTASRTLQGAEVREGFDAGFADLYHDLDQGFSPINFVFPWLPLPRNRRRDRAHNIMQQTY
LNIIKQRRSSPENPGSDMIWTLMNSKYRDGRNLKEHEIAGIMIALLMAGQHTSAATIMWALTLLGSKPEVIEMLYEEQKR
VLGEGENFHVDFDKYKDLPLLNYVIRETLRLHPPIHSIMRKVKRDLPVPDSKMVIPAGSHLLAAPGYSATHEDFFTHAKE
FCPERWGERPDDEENAEQIDYGYGLVSKGGSSPYLPFGAGRHRCIGEQFAYMHLTTIICKFVHDYTWTTVGKVPDVDYSS
MVALPLAPVKIAWKRRD
>CYP51F1 Pneumocystis carinii
AY228706 58% to CYP51F1 S. pombe
contig_349-snap.1 from Fungal Genome DB
contig_349-snap.2 from Fungal Genome DB
MGFLKTILKVLGIENFTLSFVIIILTFFFLLHIFPQLYQKDSSK
PPVVFHWLPFIGSTIQYGMDPYKFFQKQKKKHGNIFTFILLGKKMTVALGPKGNDILF
NGKLSSLSAEEAYTHLTTPVFGTDVVYDVPNHVLMEQKKFVKTGFTIETFRAYVPLII
EEVKTYLETSPIFGKDKLSGVSSLMKALPEITIFTASRTLQGKEVRSNFDASFAKLYH
DLDGGFTPINFLAPWLPLPKNRLRDAAQKKMAQIYMNIIKQRRKTCQHEEKDMIWNLM
NQHYKDGRKLTDKEIAHLMIAILMAGQHTSAATGCWALLHLAEKPEYIKLLLEEQKRV
FGDNLDDLTYDNLKDMELLSYVIKETLRLHPPLHSIIRKVKSPILIENSPYIVPKNHY
LLAAPGVSSVDEEYFENALEFIPERWKCEKNTEDSDKIDYGYGLVTKGAFSPYLPFGA
GRHRCIGEQFAYMQLGTIITIFVHELEWTLPKNQITIPKPDYTSMVVLPERPSNIEWR
RRQKR
>CYP51F1 Yarrowia lipolytica
63% to CYP51F1
S. cerevisiae
CAG82748.1
MIILTTLNNMGIPVEGWHILAGLAILAVITEIYVIGSQLLARRNKTLAPMAFYWIPWVGSSIPYGIDPYEFFEDCRNRYG
DVFSFYMLGRVMTVSLGTKGHEFVFNSKLADVSAEEAYTHLTTPVFGTGVIYDCPNSRLMEQKKFCKGALTRDAFRSYVP
KIVEEVTNFFAVNFEGKTGKADVMTTQPQMTIFTASRCLLGDEIRSKLNGDFAKLYSDLDNGFTPINFVFPNLPLPSYRK
RDLAQQKIRDTYMSVIQRRRMEKDVQDRDLIDALLKNHTYKDGKRMTPQEIAHLLIGVLMGGQHTSASTSAWMLLRLGLD
PAIQDELYQEQVDILGEADGSFRQPTYEDILTMTKLQNTIKETLRLHMPIHSIFRQVMRDLPVPGTSFVVPKGHFVMASP
GYSQQAERYFPNAKKFDPRRWMTPTEKMAESETDAEAGETVDYGFGAISKGVSSPYLPFGGGRHRCIGEQFANCQLTTLM
SCYIQNFKWTVPEGSKLPAVDTTSMITLPVHPSYIVWSKRERN
>CYP51F1 S.
cerevisiae yeast M15663 U10555
MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIIIPFIYNIV
WQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFFEECQKKYGDIFSFVLLGRVMTV
YLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTK
EAFKSYVPLIAEEVYKYFRDSKNFRLNERTTGTIDVMVTQPEMTIFTASRSLLGKEMR
AKLDTDFAYLYSDLDKGFTPINFVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNN
DIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSAATSAWILLHLAERP
DVQQELYEEQMRVLDGGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSLFRKVMKDMH
VPNTSYVIPAGYHVLVSPGYTHLRDEYFPNAHQFNIHRWNNDSASSYSVGEEVDYGFG
AISKGVSSPYLPFGGGRHRCIGEHFAYCQLGVLMSIFIRTLKWHYPEGKTVPPPDFTS
MVTLPTGPAKIIWEKRNPEQKI
>CYP51F1 Saccharomyces paradoxus
98% to 51F1 S. cerevisiae Spar_10379
MSATKSIVGEALEYVNIGLSHFLALPLAQRISLIIITPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVVYGMKPYEFF
EECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALTK
EAFKSYVPLIAEEVYKYFRDSKNFRLNERSTGTIDVMVTQPEMTIFTASRSLLGKEMRQKLDTDFAYLYSDLDKGFTPIN
FVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSA
ATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLEEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVI
PAGYHVLVSPGYTHLRDEYFPHAHQFNIHRWNNDSASSYSVGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQL
GVLMSIFIRTLKWHYPEGKSVPPPDFTSMVTLPTGPAKIIWEKRNPEQKV
>CYP51F1 Saccharomyces mikatae
96% to CYP51F1 S. cerevisiae Smik_9639
MSATKSIVGEALEYVNIGLSYFLALPLAQRISLIIITPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAIAYGMKPYEFF
EECQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALSK
EAFKSYVPLIAEEVYKYFRDSKNFRLNERSTGTIDVMVTQPEMTIFTASRSLLGKEMRQKLDTDFAYLYSDLDKGFTPIN
FVFPNLPLEHYRKRDHAQKAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSA
ATSAWILLHLAERPDVQQELYEEQMRVLDGGKKELTYDLLEEMPLLNQAIKETLRMHHPLHSLFRKVMKDMHVPNTSYVI
PEGYHVLVSPGYTHLRDEYFPHAHQFNIHRWNNDAASSYSVGEEIDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQL
GVLMSIFVRTLKWHFPEGKTVPSPDFTSMVTLPTGPAKIIWEKRDPEQKI
>CYP51F1 Saccharomyces kudriavzevii
96% to CYP51F1 S. cerevisiae Skud_Contig2067.14
MSASKSIVGEALEYVSIGLSYFLALPLAQRISLIIIAPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAIPYGTKPYGFF
EQCQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSTEAAYSHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALSK
EAFKSYVPLIAEEVYKYFRDSKNFRLNERSTGTIDVMVTQPEMTIFTASRSLLGKEMREKLNTDFAYLYSDLDKGFTPIN
FVFPNLPLEHYRKRDHAQKTISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSA
ATSAWILLHLAERPDVQQELYDEQMRVLDGGKKELTYDLLEEMPLLNQTIKETLRMHHPLHSLFRKVMKDMHVPNTSYVI
PAGYHVLVSPGYTHLRDEYFPQAHQFNIHRWNNDAASSYSVGEEIDYGFGAISKGVSSPYLPFGGGRHRCIGEHFAYCQL
GVLMSIFVRTLKWHFPEGKSVPPPDFASMVTLPTGPAKVIWEKRNPEQKI
>CYP51F1 Saccharomyces bayanus
93% to CYP51F1 S. cerevisiae Sbay_23211
MSATKSIVAEALEYVNIGLSHFMGLPLAQRISLVIIAPFIYNIVWQLLYSLRKDRPPLVFYWIPWVGSAVTYGMKPYEFF
EQCQKKYGDIFSFVLLGRVMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNSRLMEQKKFVKGALSK
EAFKSYVPLIAEEVYKYFRDSKNFRMNEKSSGTIDVMITQPEMTIFTASRSLLGKEMRQKLDTDFAYLFSDLDKGFTPIN
FVFPNLPLEHYRKRDHAQRAISGTYMSLIKERRKNNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTSA
ATSAWILLHLAERPDVQEELYEEQMRVLDGGKKELTYDLLEQMPFLNQTIKETLRLHHPLHSLFRKVMKDMHVPNSSYVI
PEGYHVLVSPGYTHLRDEYFPHAHEFNIHRWNNDASSSYSVGEEVDYGFGAISKGVTSPYLPFGGGRHRCIGEHFAYCQL
GVLMSIFVRTMKWHFPEGKSVPSPDFTSMVTLPIGPAKIIWEKRNPEQKI
>CYP51F1 Saccharomyces castellii
78% to CYP51F1 S. cerevisiae Scas_Contig699.20
MSDSITEAGNSSLIGQVFQYLQLAFQIFQSLPLAQRISLIVLAPFLYSITWQFIYSFRKDRPPLVFYWIPWVGSAVPYGH
KPYVFFENCQKKYGNIFSFMLLGRIMTVYLGPKGHEFIFNAKLADVSAEDAYSHLTTPVFGKGVIYDCSNSRLMDQKKFV
KGALSKEAFKRYVPLFKEEILKYFKDSNNFKFNQREKGEIDVMVTQPEMTIFTASRTLLGKEMRDKLDTDFAYLYSDLDK
GFTPINFVFPNLPFLEHYKKRDNAQRTIASTYLSLIKKRRANNDIQDRDLIDTLMKNSTYKDGVKMTDPEIANLLIGVLM
GGQHTSAATSAWCLLHLAERPDVQEELYQEQMRVLDNGKKEITYDLLEQMPLLNQMIKETLRLHHPLHSLFRKVIRDMQV
PNTSYVIPKDYFVLVSPGYTHLQEHYFPQAHSFNIHRWDNDAESSYVVGEEVDYGFGAITKGVTSPYLPFGGGRHRCIGE
HYAYCQLGVIMAEFIREMKWHFPSKDQTVPVSDFTSMVTLPTGPAKIVWEKRVPHETV
>CYP51F1 Saccharomyces kluyveri
79% to CYP51F1 S. cerevisiae Sklu_Contig2436.11
MSSNKVSIVQTAFEYVQLGFSHFLNLSLAQQISLVVLFPFFYSIVWQLLYSLRKDRVPMVFYWIPWVGSAVGYGTRPYEF
FAECQKKYGDVFSFMLLGRVMTVCLGPKGHEFVLNAKLADVSAEAAYTHLTTPVFGKGVIYDCPNNRLMDQKKFAKGSLT
RDSFKVYVPKIIDETYKYFRNSKNFLLNQNKSGVANVMETQPEMTIFTASRSLLGEEMRAKLDTDFAYLYSDLDKGFTPI
NFVFSHLPLESYRKRDRAQQLISSTYMSLIRKRRENNDIQDRDLIDALMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTS
AATSAWLLLHLAEKPELQEELYAEQMRVLDNGKKELTYDLLQEMPLLNQTIKETLRMHHPLHSIFRKVMRDLPVPNTSYV
VPKGHHVLVSPGYAHLRDEYFPHAATFDPHRWDNDAASSYSSSEQVDYGFGSVSKGVSSPYLPFGGGRHRCVGEHFAYCQ
LGTIMSVYIRTLKWSFPPEMKGVPSPDFQSMVTLPCEPAKIKWEKREPAQTI
>CYP51F1 Kluyveromyces waltii
77% to CYP51F1 S. cerevisiae kwal_154-g13.1
MDSTNSSVVGKIFSKGIEIGSALLSRFLALSIAQQASLIIAAPFVYVIVWQFLYSMRKDRVPLAFYWIPWVGSAVTYGMR
PYEFFAECQEKYGDVFSFVLLGRVMTVCLGPKGHEFVLNAKLADVSAEAAYTHLTTPVFGKGVIYDCPNARLMEQKKFVK
GALSTESFRGYVPLIAEEVYQYFRNSKNFDMNHKKSGVANVMVTQPEMTIFTASRSLLGKEMRNLLNTDFAYLYSDLDKG
FQPINFVFSHLPLEHYRKRDHAQQTISSTYMKLIKQRRENNDIQDRDLIDTLMKNSTYKDGTKMTDQEIANLLIGVLMGG
QHTSAATSAWMLLHLAERPDLQEELYAEQMEVLDNGKKELTYELLQQMPLLNQTIKETLRMHHPLHSIFRRVERDLPVPK
TQYVVPRGHFVLVSPGYCHLQDEYFPKANTFDPHRWNNDYKSSYATGEEVDYGFGAISKGVSSPYLPFGGGRHRCIGEHF
AYCQLGVLMSVYIRTVKWKFTPKMHGVPKPDFASMVTLPLCPAEIEWEKRDPQQAL
>CYP51F1 Ashbya gossypii ATCC 10895
71% to CYP51F1 S. cerevisiae, NP_984259.1
MSESLLQTVVAYVELVLHHFMALSWTQQLSIVIVAPFIYSLVWQTLYSFRKDRVPLVPFMVPWVGSALAYGRAPYEFFGK
CQQKYGDVFAFMLLGRVMTVYLGTKGHEFILNAKLAEVSAEEAYTKLTTPVFGEGVVYDCPNHRLMEQKKFCKNALSTEA
FRRYVPMVMDEVRKYLRTSKHFMMNERSSGVVNVMETQPEMTIFTASRSLLGAEMHSMLDADFAYLYADLDKGFTPLNFV
FRDLPLDNYRRRDNAQRTISSTYMKVIERRRKNNDVQDRDLIDALMTSAQYKDGVKMTDQQIANLLIGVLMGGQHTSAAT
SAWVLLHLAERPDIQEELYEEQMRVLDGGAKELTYELLQEMPLLNQVIKETLRMHHPLHSLFRKVTRDMPVPNTSYVIPK
DHYVLASPGFCHLSEEYFPNAKEFNPHRWDNDAASSVSTGEKVDYGFGAISKGVSSPYLPFGGGRHRCIGEGFAYMQLGT
IFSVVVRSMKWHFPADMKGVPNPDFTSMVTLPSEPCRIAWERRVPDQII
>CYP51F1 Kluyveromyces polysporus
Kpol_1004p61
81% to CYP51F1 S. cerevisiae
MSDQSIVASLAEYVTIGLSYFMSLPLSQRISIVFIAPFIYSITWQLLYSLRKDRPPLVFYWIPWVGSAVTYGSKPYQFFG
DCQKKYGDCFSFMLLGRIMTVYLGPKGHEFVFNAKLADVSAEAAYAHLTTPVFGKGVIYDCPNHRLMDQKKFVKGALTKE
AFARYVPLMVEEMVKYLRSSPFFKINEKSEGTVNVLATQSEMTIFTASRSLLGKEMRDKLDTDFAYLYSDLDKGFTPINF
VFPNLPLEHYRKRDNAQRVISSTYLSLIKKRRDENDIQDRDLVDTLMKNSTYKDGVKMTDKEIANLLIGVLMGGQHTSAA
TSAWALLHLAERPDVQKELYEEQMRVLDNGKKELTYDLIQEMPLLNQCIKETLRLHHPLHSIFRKVMKDMKVPNTSYVVP
KDYYVMVSPGYTHLQDEYFPNAKQFNMHRWDNDATSSYSVGEEIDYGFGVVTKGVSSPYLPFGGGRHRCIGEHFAYCQLG
VLMSIFIRTMTWKFPEGRTVPNSDFQSMVTLPLNPADIIWTKRDAAQVI
>CYP51F1 Kluyveromyces lactis
76% to CYP51F1 Saccharomyces kluyveri
KLLA0E03553g
MSTKSESVVVKVFEAAQAVLGQFLAFSIAQQISIVILLPFVYTIVWQLLYSMRKDRVPLVFYWIPWVGSAVSYGMRPYEF
FEECREKYGDIFAFVLLGKVMTVYLGPKGHEFILNAKLADVSAEAAYTHLTTPVFGNGVIYDCPNHRLMDQKKFVKGALT
TDAFRKYVPLIAEEVQKYFLTSKNFSIGEKDHGKINVMVTQPEMTIFTASRSLLGSEMREKLNTDFAYLYSDLDKGFTPL
NFVFSHLPLDNYRKRDNAQRVISSTYLSLIKKRRDTNDIQDRDLIDSLMKNSTYKDGVKMTDQEIANLLIGVLMGGQHTS
AATSAWVILHLAERPDIQEKLYEEQMKVLDNGTKELTFDLLQEMPLLNQTIKETLRLHHPLHSLFRKVMNDMPVPNSSYV
VPKGHHVLVSPGYCHLQDKYFPNASEFNPNRWDNDAASSYASNEKVDYGFGSISKGVSSPYLPFGGGRHRCIGEHFAYMQ
LGTILSNYIRTLTWKFADPSATVPTPDFQSMVTLPLEPSEIEWTLRK
>CYP51F1 Kluyveromyces marxianus X97682
88% to CYP51F1
Kluyveromyces lactis
MTDQEIANLLSILMGGQHTSAATSAWAILHLAERPDVQQELYEE
QMRVLDNGKKELTYDLLQEMPFLNQTIKETLRLHHPLHSLFRKVMNDMPVPNTSYVVP
KGDHVLVSPG
>CYP51F1 Fusarium graminearum FG01000.1
AACM01000048 FGcontig1.48_scaffold1
MGLLQELAGHPLAQQFQELPLGQQVGIGFAVFLVLSVVLNVLNQLLFRNP
NEPPMVFHWFPFVGSTITYGMDPPTFFRENRAKHGDVFTFILLGKKTTVA
VGPAGNDFILNGKLKDVCAEEIYTVLTTPVFGKDVVYDCPNAKLMEQKKF
MKIALTTEAFRSYVPIISSEVRDYFKRSPDFKGKSGIADIPKKMAEITIF
TASHALQGSAIRSKFDESLAALYHDLDMGFTPINFMLHWAPLPWNRKRDH
AQRTVAKIYMDTIKERRAKGNNESEHDMMKHLMNSTYKNGIRVPDHEVAH
MMIALLMAGQHSSSSTSSWIMLRLAQYPHIMEELYQEQVKNLGADLPPLT
YEDLAKLPLNQAIVKETLRLHAPIHSIMRAVKSPMPVPGTKYVIPTSHTL
LAAPGVSATDSAFFPNPDEWDPHRWEADSPNFPRMASKGEDEEKIDYGYG
LVSKGSASPYLPFGAGRHRCIGEHFANAQLQTIVAEVVREFKFRNVDGGH
TLIDTDYASLFSRPLEPANIHWERRQ*
>CYP51F1 Aspergillus nidulans AN8283.1 51
clan
MGLVSLVLDNVCERCSALSVWALSGLGLLSVIIIAVVLNVLRQILFKNPN
EPPVVFHWFPFIGSTISYGIDPYKFFFNCRAQYGDIFTFVLLGKKTTVYL
GTKGNDFILNGKLKDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFV
KYGLTSDALRSYVQLITAEVEDFAQKSSVFQNAKGVFDVSRTIAEITIYT
ASRSLQGKEVRDKFDSTFAELYHDLDMGFAPINFMLPYAPLPHNRKRDAA
QRKMAETYMEIIKERRKSGEKKDSEDMVWNLMSCVYKNGTPLSDEEIAHM
MIALLMAGQHSSSSTLSWILLHLARHPEIVEELYQEQLKVLGSDMHMTYD
DLQKLELHSKIIKETLRIHAPIHSIIRAVKSPMPVPGTSYVIPTSHNVLS
SPGVTARSDEFFPNPLKWDPHRWDSNPIANSTEDEEKIDYGYGLVSKGTN
SPYLPFGAGRHRCIGEQFAYVQLITVTAALVRLFKFDTVSESDKSSVPET
DYSSLFSRPAGKCFVQYEKRNVTTKA*
>CYP51F1 Nectria haematococca fgenesh1_pg.scaffold_2000426
89% to CYP51F1 F. gram.
Necha1/scaffold_2:1348428-1350174
89% to Fusarium graminearum CYP51F1
FG01000.1 AACM01000048 FGcontig1.48_scaffold1
This gene model seems correct DRN 2/4/06
MGLLHEIAGHPLAQQFQELPLGQQVGIGFGAIVVLSVILNILSQILFVNPNEPPMVFHWFPFIGSTVTYG
MDPPRFFKENRAK (0)
FGDVFTFVLLGKKTTVAVGPSGNDFILNGKLKDVCAEEIYTVLTTPVFGKDVVYDCPNAKLMEQKK
(0)
FMKIALTTEAFRSYVPIISGEVRDYFKKSADFKGKTGIVDIPKKMAEITIFTASHALQGSV
IRSKFDESLAALYHDLDMGFTPINFMLHWAPLPWNRKRDHAQRTVAKIYMDTIRERRIKDNDDSEHDMMK
HLMNSTYKNGTPVPDHEIAHMMIALLMAGQHSSSSTSSWIMLRLAQYPQIMEELYQEQVKALGADLPPLK
FEDLAKLPLNQAIIKETLRLHAPIHSIMRAVKSPMPVPGTKYVIPTSHTLLAAPGVSASDPAYFPNPDEW
DPHRWEAGSPNAPTIARNNAEEEEKIDYGYGLVSKGSASPYLPFGAGRHRCIGEHFANVQLQTIVAEVVR
EFKFSNVDGGNTLIGTDYASLFSRPLEPANIRWERRQ*
>CYP51F1 Magnaporthe grisea MG04432.4 75% to CYP51 AACU01001110 cont2.837
MGLLQDTTGPLVDAFYQLGTGAQVGVAFVSFIFLSVFFHVAQQIFFKNPH
EPPVVFSWFPVVGSTVTYGKDPPQFFRDMAKKYGNIFTFILLGKKTTVYI
GTEGNEFILNGKLRDVNAEEIYGPMTTPVFGKDVVYDCPNAKLMEQKKFM
KIALTTEAFRSYVPIIADEVSSYLKRTPAFKGPSGVVNIPPKMAEITIFT
ASHALQGKEIRDQFDETLADLYHDLDMGFHPVNFKLHWLPLPRNIRRDKA
QKTIAKIYMDTIQRRRAKGKDSEAKDMMYHLMNSTYKNGTPVPDHEIAHM
MIALLMAGQHSSSSTSSWIMLRLASRPDIMEELYQEQVRALGADLPPLRY
EDLANLPLHLAVIKETLRLHAPINSILRAVKQDLPVPGTNYVIAKDTTVL
AAPGYSAGDPNHFPEPELWEPHRWEADSRLAPRISMSNDNDEEEKIDYGY
GLVSKGTTSPYLPFGAGRHRCIGEHFANVQLQTIVAMIVREFKFRNVDGS
GKVVGTNYASLFSRPEEPAKIYWERR*
>CYP51F1
Ustilago maydis Z48164
MVASSSSATASLLDQLFALTPLADSSAWIKTITVLVLLPLLAVV
LNVASQLLLATPKNHPPVVFHFVPVIGSAIYYGIDPYKFFFECREKYGDVFTFVLLGR
KITVALGPKGSNLVFNAKHQQVTAEDAYTHLTTPVFGKEVVYDVPNAVFMEQKKFVKV
GLSIENFRVYVPQIVDEVREYIKSDARFSALKTRKTITVDIFQAMSELIILTASRTLQ
GKEVRQGLDKSFAQLYHDLDSGFTPINFVIPNLPLPSNFKRDRAQKKMSQFYQDIVAK
RRAAGASTSADDASGENDMIAALIEQKYKNGRALSGVEIAHMMIALLMAGQHTSSATS
SWAFLRLASRPEIIEELYEEQLNVYSDGHGGLRELDYETQKTSVPLLDAVVKETLRLH
PPLHSIMRYVKSDLAVPPTLSSPTSTKSEPDAHYVIPKGHYIMAAPGVSQVDPQIWKS
SDQFDPHRWLDATTAAAMQDSGEDKQDFGFGMISTGANSPYLPFGAGRHRCIGEQFAY
LQIGVILATFVRIFKWHLDSKFPDPDYQSMVVLPSKNGCAIVLTPRAESLHLD
>CYP51F1 Puccinia graminis f. sp. tritici
55% to CYP51F1 Malassezia globosa with a short seq gap.
PGTG_07202 revised
MSSLIDPLIEFIGSFSTFNQILIYFLLSITSIISINIFNQLAIPKDPTTPPVVFHLFPFIGSAVSYGIDPYAFLESCRKK
YGNVFTFVLLNKKVTVALGLEGNALILNGKLSQVNAEEAYTAL
(1)
TATPVFGTKMVYDVPNAILMXXXXXXXXXXXXX
NFRKYVTLIADETISYLEDHVFE (1)
KPKTQQAVKDCFKVASEITICTAS
ATLQGPEVREGLNKSFANLYHDLDGGFTPLHFAFPNLPLPSYRRRDRAQVAMRNFYMNIIQKRREDNREGQLGDMIDSLQ
GQTYKDGRPLTDKEIAHIMIALLMAGQHTSAATGSWLLLHLASRPDIVAELRQEQIEVFGKPGQTDDKELDPLDLERVQS
PLMLACIKEVLRLHPPIHSIMRKVKSPITVPRTLASHNEDTPYIIPSSNFVLAAPGASQIDPAIWSSPHEFEPSRWLKLT
SPFKAGGGETQEEMVDYGFGMISSGANSPFLPFGAGRHRCIGEQFAYLQLSTLGATVIRNCELELVSNQFPKPDYTTMLV
CPIKPRDVKFTRRNTHS
>CYP51F1 Sporobolomyces roseus
55% to CYP51F1 Ustilago maydis, e_gw1.1.480.1
MGLATLALTAVLYFAGASLSIVALNVLHQLLAPRDPTKPPLVFHYVPVIGCAVSYGMDPLGFLDDCKQKYGPVFTYPLLG
RRITATLGPLGSNFVLNGKLAHVNAEEAYTHLTTPVFGTEVVYDVPNHVLMEQKKFVKFGLTTDNFRRYVGLIRQEVLGY
VSTHVFDQDVLANGVDAFTTSSEITILTASATLQGREVRQAMDKSFAELYHDLDGGFTPLNFVFPNLPLPSYRRRDRAQL
KMREFYISILEKRRASTDEPDLDMLTALQNQSYRNGEPLTDKQIAHIMIALLMAGQHTSAATGAWAILRLGENQDLQRRL
WEEQVEYHMDKETNTLNELTYENFQTPLLVATIKELLRMHPPLHSLMRKVISDCPVPSSVGSPSAEPRASHAFKKSNESK
EYVIPKGEFVLAAPGYSQVDESIWGKDAKEFRVERWLESEGGNKVPGDEDEGEEDYGWGKISRGGKSAYLPFGAGRHRCI
GEQFAQVQLGTIIATLVRELTWTLDQPFPGNDYTVRPSLFLLEAHESACTDCAPFV
>CYP51F1 Malassezia globosa
67% to CYP51F1 Ustilago maydis, MGL_2415
MLQEIGAWPVWQQALTFLVGGLALIVGINVLVQVLVPRNKSLPPMVFHWVPVVGSAITYGMDPYRFFFNCREKYGDVFTF
KLFGRNVTVALGPKGSNLVFNGRLTQVSAEEAYTSLTTPVFGKGVVYDVPNAVLMEQKRFVKSGLSMENFRMYVTQIESE
VKDFINNDAAFLPLQKGATSVTVDIFNVFSEITILTASRTLQGKEVRESLDKTFAKLYHDLDSGFTPINFVIPNLPLPNN
FRRDRAQRLMSDFYLGIIKKRREGNTEGTEHDMISALMEQSYKNGRNINDREIAHMMIALLMAGQHTSSATGSWAMLRLA
SRPEIIEELYEEQKRVYSDGTGGFAPLDYDIQKSSVPVLDAVIRETLRLHPPIHSIMRKVKSDMVVPPTLAAPISSKGSR
DETYVIPKGHYVIAAPGVSQVDPKIWEDASRFDPHRWLGDKANVMNQTDDAQEDFGWGMVSTGANSPYLPFGAGRHRCIG
EQFAYLQLGTIISTFVRAFDWRLETKLPAPDYTSMVVLPTQPANLVFTPRKNKA
>CYP51F1
Penicillium italicum Z49750
MDLVPLVTGQILGIAYYTTGLFLVSIVLNVIKQLIFYNRKEPPV
VFHWIPFIGSTIAYGMDPYQFFFASRAKYGDIFTFILLGKKTTVYLGVEGNEFILNGK
LKDVNAEEVYGKLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLSQEALESYVPLIADET
NAYIKSSPNFKGQSGTIDLAAAMAEITIFTAARTLQGEEVRSKLTSEFADLFHDLDLG
FSPINFMLPWAPLPHNASAIKHTTYARDLSGNYPSATGSWRRRQRRRQDKSKGTDMIS
NLMRCVYRDGTPIPDKEIAHMMITLLMAGQHSSSAISCWILLRLASQPEMAEKLHAEQ
IKNLGADLPPLQYKDMDKLPLLRNVIKETLRLHSSIHTLMRKVKNPMPVPGTDFVVPP
SHTLLSSPGVTARDERHFRDPLRWDPHRWESRVEVEDSSDTVDYGYGAVSKGTRSPYL
PFGAGRHRCIGEKFAYLNLEVIVATLVREFRFFNPEGMEGVPDTDYSSLFSRPVQPAT
VRWEVRS
>CYP51F1
Candida tropicalis M23673
MAIVDTAIDGINYFLSLSLTQQITILVVFPFIYNIAWQLLYSLR
KDRVPMVFYWIPWFGSAASYGMQPYEFFEKCRLKYGDVFSFMLLGKVMTVYLGPKGHE
FIYNAKLSDVSAEEAYTHLTTPVFGKGVIYDCPNSRLMEQKKFAKFALTTDSFKTYVP
KIREEVLNYFVNDVSFKTKERDHGVASVMKTQPEITIFTASRCLFGDEMRKSFDRSFA
QLYADLDKGFTPINFVFPNLPLPHYWRRDAAQRKISAHYMKEIKRRRESGDIDPKRDL
IDSLLVNSTYKDGVKMTDQEIANLLIGVLMGGQHTSASTSAWFLLHLAEQPQLQDDLY
EELTNLLKEKGGDLNDLTYEDLQKLPLVNNTIKETLRMHMPLHSIFRKVMNPLRVPNT
KYVIPKGHYVLVSAGYAHTSDRWFEHPEHFNPRRWESDDTKASAVSFNSEDTVDYGFG
KISKGVSSPYLPFGGGRHRCIGEQFAYVQLGTILTTYIYNFKWRLNGDKVPDVDYQSM
VTLPLEPAEIVWEKRDTCMV
>CYP51F1 N.
crassa AABX01000052.1 cont3.136 NCU02624.1 (version3)
2384
MGILQVVAGPLSQQFSQLGTVSQIGVAIASFLFVAVVLNVLQQFLFKKPN
EPPLVFHWFPLIGSTITYGMDPPRFFKENREK
(0) 2139
2066
YGDCFTFILLGKKTTVYVGPKGNDFILNGKIRDVNAEEIYTVLT
TPVFGKDVVYDCPNSKLMEQKK
(0) 1869
1806
FMKIALTTEAFRQYVPIISDEVTSYLKR
TADFKGKSGIVDIPPKMAQITIFTASHALQGKEIRDKFDETLADLYHDLD
MGFSPINFMLHWAPLPWNNRRDYAQRTVAKIYMDTIKERRARGETGAQDI
MWHLMNSTYKGDVPVPDHEIAHMMIALLMAGQHSSSSTSSWIMLRLASRP
DIMEDLYNEQVKNLGADLPPLTYEDLAKLPLHAAIVKETLRLHAPIHSIM
RAVKTPMPVPGTKYVIPTDHVLLAAPGVSATDESYFPQPDLWEPHRWEKD
SPLAPTIVRNVPSEEDDEKIDYGYGLVSKGANSPYLPFGAGRHRCIGEQF
ANVQLQTILAIIVRNFKFRNVDGSDKVIGTDYASLFSRPLEPAKIYWERR
EGCQL* 655
>CYP51F1 ug.2.6.1(CYP51) Phanerochaete chrysosporium
MSLSQYGPIAGLVGQAYDALASMSTSRLVLFLLINIPILSVVCNVIYQLLPKDKSLPPVVWHWFPWFGSAAAYGEDPIKFFFDCKEKYGNVFTFILMGRKVTVALTPAGNNFIMGGKHTTFSAEEVYGGLTTPVFGKDVVYDCPNELLMEQKKFVKFGLSTENFRQYVGMIEEEVLQFMRNDASFKIYQMNDINEWGAFDVLKVMSEITILTASRTLQGKEVRANITKDYAQVYNDLDGGFTPLHFMFPNLPLESYRKRDAAHKKISDFYISIIRKRRENPGQEEHDMIAALMNQKYRVGRPLKDHEIAHIMIALLMAGQHTSSATGSWALLHIADRPDVAEALYEEQVKHFRQSDGSWRTPEYEELKELPVLDSVIRETLRIHPPIHSIMRAVREDVVVPPTLAAPSEDGRYVIPKGHVVLSSAAISQVDPMLWKNANDWDPSRWSDPEGVAAQAYKQYDDAEGAKVDFGFGLVSKGTDSPYQPFGAGRHRCIGEQFAYLQLGTIISTFVRHVEMRLPETGVPPPNYHAMITLPKAPRNILYRRRNFD
>CYP51F1 Cryptococcus neoformans var.
neoformans B-3501A chromosome 1
56% to CYP51F1 Phanerochaete chrysosporium
AAEY01000001
CNBA0300"
ESTs gb|CF192489.1|CF192489,
gb|CF192488.1|CF192488,
gb|CF191439.1|CF191439;
EAL23379.1"
MSAIIPQVQQLLGQVAQFFPPWFAALPTSLKVAIAVVGIPALII
GLNVFQQLCLPRRKDLPPVVFHYIPWFGSAAYYGEDPYKFLFECRDKYGDLFTFILMG
RRITVALGPKGNNLSLGGKISQVSAEEAYTHLTTPVFGKGVVYDCPNEMLMQQKKFIK
SGLTTESLQSYPPMITSECEDFFTKEVGISPQKPSATLDLLKAMSELIILTASRTLQG
KEVRESLNGQFAKYYEDLDGGFTPLNFMFPNLPLPSYKRRDEAQKAMSDFYLKIMENR
RKGESDHEHDMIENLQSCKYRNGVPLSDRDIAHIMIALLMAGQHTSSATSSWTLLHLA
DRPDVVEALYQEQKQKLGNPDGTFRDYRYEDLKELPIMDSIIRETLRMHAPIHSIYRK
VLSDIPVPPSLSAPSENGQYIIPKGHYIMAAPGVSQMDPRIWQDAKVWNPARWHDEKG
FAAAAMVQYTKAEQVDYGFGSVSKGTESPYQPFGAGRHRCVGEQFAYTQLSTIFTYVV
RNFTLKLAVPKFPETNYRTMIVQPNNPLVTFTLRNAEVKQEV
>CYP51F1 P450-40 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
46% to CYP51F1 Aspergillus fumigatus = CYP51F1
RO3G_11790.1
MAVISTLLPTLESIPLYAVLALGVFVIINILSQWFGPKNPKEPPVVFSWIPFMGNAIEFGINPIAFLQKCQKKYGDVFTFYMVGKRVTVFLNADGNQFVFNAKQNLTSAADAYNHMTKHVFGPEVVYDAPHSVFMEQKRFIKAGLNSESFRQHVPMIVEEVEGFFKNYKKPTGAFDAYHTLGELIICTASRCLMGKEIRASLDDSVAGLYYDLDQGFKPINFIFPNLPLPSYRKRDVARQKMTDLYSSIIARRKAENDFSNADLLQALMDANYKDGSNVPDHHIAGMMIAVLFGGQHTSATTSAWTLLELAARPDLIRDLREEQITKLGSLKADLTFDNLKELTLLDSCVRETLRLHPPIFQMMRRVTANKVVFEKTGHEIPKGNFLCAVPGVTQVDSQYFNEPLKYDPLRWINLTDPVHSMEAGDDSNIDYGFGAVGISSKNPFLPFGAGRHRCIGEQFGYLQIKTIIATIIRLFDIELEDGKGVPKSDYTSMVVVPERPSNIKYTWRE
>CYP51F1P Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
60% TO CYP51F1 Rhizopus oryzae
RO3G_08504.1 revised
NSIALYKNAKKKKSNVFTFHLVGKRVTLFLKAEDNQFVFNAKQNLISAANTHNYMTKHVFGPENVYSVPQCVFMEQK
()
XXXXXXXXXXNYSQHVL
MIVEEVESFFKDFKKPTSASDAYHILEKLIICTASRCLTDKETRVYLDDSAASLYYVLGQRFKSISFIFPNLPSHSYGKH
DVVRQKMADFYSNIIACRKVENDF
(0)
SNADLLQSLMDAIYKNRIHISDHDITSMVIAILL &
E*YTFTTTSAWTLLELANRTSL &
IHGLRKEQITRLGSLKSSLTLDKFKKSTSLDDCIHKTLRLHPSIF*IRATADKIIYEK
TGHEISKDNLLCAVSSVTQINDQYYNSPLKYSRL**INLINPFHLREVGDDNDVDDNFDAVSVFSSNLFLPVGVVR
&
HKCAGEQFGYQLLPL*PRLFDTKLEASRGVPKTNYTLMVVAPKRSSTIKYMERE
>CYP51F1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
73% to CYP51F1
Rhizopus oryzae
estExt_fgeneshPB_pg.C_10567
MAILSLITQVVPSITSVFLYGTLSLVVVFSIHILSQLVVPRDPNQPKLVFSWVPFLGNGVEFGMNPIGFIQKCQKLYGDV
FTFKLVGKSVTVCLGADGNQFVFNNKQNLSSAAEAYNDMTKHVFGFDVVYDAPHSVFMEQKRFIKAGLTLESFRAHVPLI
VKETTEFFKDFKKPTGYMDAYSTFSKLIICTASRCLMGKEIRSALHEGVADLYYDLDQGFQPINFMFPNLPLPSYRRRDV
AREKMAELYSKIIRRRKEENDTSNNDLLQALIESTYKDGTPIPDHHIAGMMIAVLFGGQHTSATTSAWTTLELANRPDLV
QALREEQIAKLGSLKADLTFENLKELTLMEACIKETLRLHPPIFQMMRKVIADKVVFEKTGHEIPKNDFLCAVPGATQVD
EQYFNEPLTYNPYRWIEKSDPVHQMEVGEDANADYGFGIVGISSRSPFLPFGAGRHRCIGEQFGYLQLKAVMATVIRLYD
LSLEEGKGVPESDYTSMVVVPKHPANVVYTCRE*
>CYP51F1 Batrachochytrium dendrobatidis
JEL423 (chytrid)
43% to CYP51F1 Rhizopus oryzae
note this species has no obvious CYP61
sequence
BDEG_01891
MGLFFEAYESVRNVSGLPPDQFHTVVAITSLVFVLTVWLLSYALNQPLKSKDTGSEPPRVPVSIPFIGAAIAYGVDPIKF
LIECRQKYGDCFTFVMLGRKMTFCLGPDGNHYVFNVPVADATAEGAYKKLTVPVFGAGVVYDVHNAMFMEQKKFVKDAFN
SNSFNAYMLNIWNETNAFFNDWEDHYDANMIFDEMSELTIRTASHCLLGKEIRQQLHSTVAQLYHDLDSGLAPINVFFRW
LPLPVYFKRDRANKIMSKTFVDIIKKRRATNSTDNADLMQTLMFARYRDGTSMTDDEIAHLLIATLMGGQHTSSTTLCWM
LFELARRQDIVDKLLHEQSMVLTGKPDTPPEDLPEFTHEQIRQLTFLDCVMKETLRLHPPIHTVMRKVEKSMTYRGMTIP
AGHFICGSAAVSHLDPTRFPDPLKFEPSRFLNNDEGSGEWSINTIDIAQKSARSHFLPFGAGRHRCIGEAFAYIQNKTIL
SAFIRRYTHKLYVDPNTGKEHFPSSDYTSLITIPEKPARLSITRRSVKA
>CYP51F1 Fusarium oxysporum
92% to CYP51F1 Fusarium graminearum
FOXG_00394
MGLLQELASHPLAQQYQELPLGQQIGIGFGAFIILSVVLNVLNQLLFKNRNEPPLVFHWFPFVGSTITYGMDPPKFFKEN
RAKHGDVFTFVLLGKKTTVAVGPTGNDFILNGKLKDVSAEEIYTVLTTPVFGKDVVYDCPNAKLMEQKKFMKIALTTEAF
RSYVPIISAEVRDYFKKSPDFKGKSGIVDIPKKMAEITIFTASHALQGSVIRNKFDESLAALYHDLDMGFTPINFMLHWA
PLPWNRKRDHAQRTVAKIYMDTIKERRAKDNDDTEHDMMKHLMNSTYKNGTPVPDHEVAHMMIALLMAGQHSSSSTSSWI
MLRLAQYPHIMEELYQEQVRELGADLPPLTYDNLAKLPLNQAIIKETLRLHAPIHSIMRAVKSPMPVPGTKYTIPTSHTL
LAAPGVSATDSAYFPNPDEWDPHRWEVDSPNFPRMATRGDDEEKIDYGYGLVSKGSASPYLPFGAGRHRCIGEHFANAQL
QTIVAEVVREFKFRNVDGGNTLIDTDYASLFSRPLEPANIHWERRQQ*
>CYP51F1 Fusarium verticillioides
98% to CYP51F1 Fusarium oxysporum
FVEG_01123
MGLLQELASHPLAQQYQELPLAQQIGIGFGAFVVLSVVLNVLNQLLFKNRNEPPLVFH
WFPFVGSTITYGMDPPKFFRENRAKHGDVFTFVLLGKKTTVA
VGPTGNDFILNGKLKDVSAEEIYTVLTTPVFGKDVVYDCPNAKLME
QKKFMKIALTTEAFRSYVPIISSEVRDYFKKSPDFKGKSGIVDIPKKMAEITIF
TASHALQGSVIRNKFDESLAALYHDLDMGFTPINFMLHWAPLPWNRKR
DHAQRTVAKIYMDTIKERRAKDNDDTEHDMMKHLMNSTYKNGTPVPDHEVAH
MMIALLMAGQHSSSSTSSWIMLRLAQYPHIMEELYQEQVRELGADLPPL
TYDDLAKLPLNQAIIKETLRLHAPIHSIMRAVKSPMPVPGTKYTIPTSHTL
LAAPGVSATDSAYFPNPDEWDPHRWEADSPNFPRMANRGDDEEKIDYGYG
LVSKGSASPYLPFGAGRHRCIGEHFANAQLQTIVAEVVREFKFRNVDGGN
TLIDTDYASLFSRPLEPANIHWERRQQ*
>CYP51F2 Fusarium graminearum FG04092.1
AACM01000179 FGcontig1.179_scaffold2
MFHLLIYPLWVLVALFAVIIANLLYQQLPRRPDEPPLVFHWFPFFGNAVA
YGLDPCGFFEKCREKHGDVFTFILFGRKIVACLGVDGNDFVLNSRLQDAN
AEEVYGPLTIPVFGSDVVYDCPNSKLMEQKKFVKFGLTQKALESHVQLIE
REVLDYVETDPSFSGRTSTIDVPKAMAEITIFTASRSLQGEEVRRKLTAE
FAALYHDLDLGFRPVNFLFPWLPLPHNRKRDAAHIKMREVYMDIINDRRK
GGIRTEDGTDMIANLMGCTYKNGQPVPDKEIAHMMITLLMAGQHSSSSAS
SWIVLHLASSPDITEELYQEQLVNLSVNGALPPLQYSDLDKLPLLQNVVK
ETLRVHSSIHSILRKVKRPMQVPNSPYTITTDKVIMASPTVTAMSEEYFE
NAKTWNPHRWDNRAKEEVDTEDVIDYGYGAVSKGTKSPYLPFGAGRHRCI
GEKFAYVNLGVIVATLVRNFRLSTIDGRPGVPETDYTSLFSRPAQPAFIR
WERRKKI*
>CYP51F2 Aspergillus nidulans AN1901.1 64%
to 51F2, 60% to 51F1
MLSPTLFSAYVLVGAIVAVLVNVIRQIFFRNKNEPPMVFHWVPFVGSTIS
YGMNPYKFFFSCREKYGDIYTFVMLGKKMTVYMGVKGNDFILNGKLKDLN
AEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKFGLSQSALESHVPLIE
KEVLDYIKTSPRFKGDSGVLDAPAAMAELTIYTAGSALQGKEVRKKLTAE
FADLFHDLEMGFTPINFILPWAPLPQNRKRDIAHARMRETYMEIINQRRK
NPDAQDHDMIWNLMHSTYKNGNPVPDKEIAHIMITLLMAGQHSSSSISAW
ILLRLASEPQILEELYQEQLANLKRDPRTGAFEPLQYKDLDLLPLHQNVI
KETLRVHLSIHSILRKVKNPIPVPDTPYIIPTSHTLLASPGATALSDEYF
PNANMWDPHRWENQRPDKEDEEGELIDYGYGAVSKRMSSPYLPFGGGRHR
CIGEKFAYVNLGVIVATIVRNLKLYNVDGKTGVPATDYSSMFMGPMKPAV
VGWERRFPARS*
>CYP51F2 Aspergillus niger CBS 513.88
XM_001394187.1,
CAK40582.1
80% to CYP51F2
Aspergillus fumigatus
MALLAVAGVYAFAALLVAIVLNVTRQLLFRNEKEPPVVFHWIPF
LGSTISYGMDPYTFFFSCRKKYGDIFTFVLLGQKTTVYLGVQGNDFILNGKLKDVSAE
EVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKFGLTQAALESHVQLIEKETLDYLRDS
PRFNGASGVIDIPAAMAEITIYTAARALQGEEVRKKLTAEFAELYHDLDKGFSPINFM
LPWAPLPHNQKRDAAHARMREIYTDIINERRKNPDEEKSDMIWNLMHCTYKSGQPVPD
KEIAHMMITLLMAGQHSSSSISSWIMLRLASEPQVLEELYQEQLASLSNRNGVFEPLQ
YQDLDKLPFLQSVIKETLRIHSSIHSIMRKVKNPLPVPGTSYIIPEDHVLLASPGVTA
LSDEYFPNATRWDPHRWENQPDKEEDGEMVDYGYGSVSKGTASPYLPFGAGRHRCIGE
KFAYVNLGVIIATIVRHLKLFNVDGRKGVPGTDYSTLFSGPMKPAIVGWERRFPDHSK
GSLN
>CYP51F2 Aspergillus terreus NIH2624
XM_001215095.1
78% to CYP51F2
Aspergillus fumigatus
ATEG_05917.1
MSLLTITSYAAVGILALIAWNVIRQLLFQNKSEPPVVFHWIPFL
GSTISYGIDPYAFFASCRQKYGDIFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEE
VYSPLTTPVFGSDVVYDCPNAKLMEQKKFIKYGLTQAALESHVQLIEREVLDYLRTSP
NFHGASGVVDISAAMAELTIFTAGRALQGEEVRRKLTAEFADLYHDLDKGFTPINFML
PWAPLPHNRKRDAAHARMRAIYMDIIRERRAHKNPDQVEAGSDSDMIWNLMRCTYKDG
QPVPDKEIAHMMITLLMAGQHSSSSISAWIFLRLASEPRVLEELYQEQVASLGKPDAD
GVFPPLQFRDLDRLPLHQNVVKETLRLHSSIHSIMRKVKNPLPVPGTPYVVPTSHVLL
ASPGVTATSDEYFPNASRWDPHRWENQAEPDDDGEMVDYGYGRVSKGTASPYLPFGGG
RHRCIGEKFAYINLGVIVATVVRHLKLANVDGRKGVPQTDYSSLFSGPVKPAIIGWER
RFPTA
>CYP51F2 Aspergillus clavatus NRRL 1
XM_001271578.1
ACLA_046180
81% to CYP51F2
Aspergillus fumigatus
MLSLTLFGLYLVSATAVVILVNVVYQHLFRLRNRTEPPMVFHWI
PFIGSTITYGIDPCKFFFACREKYGNIFTFILLGQKVTVYLGVEGNEFILNGKLKDVN
AEEVYSPLTTPVFGSDVVYDCPNSKFMEQKKFIKFGLTQSALEAHVPLIEKEVLDYLE
TSPRFQGTSGLVDIAAAMAEITIFTAARALQGEEVRSKLTAEFADLYHDLDRCFTPVN
FMFPWAPLPRNKKRDAAHVRMRAIYVDIINQRRRDGGEDTQKSDMIWNLMNCSYKNGQ
QVPDKEIAHMMITLLMAGQHSSSSIGSWIMLRLASQPEVLEKLYQEQLDKLAQGGPGS
NLRPLQYKDLELLPYHQHVIRETLRLHSSIHSILRKVKNTLSVPGTSYVIPPGRVLLA
SPGVTALSDEHFPNASRWDPQRWENQTTKEDSGEMVDYGYGAVSKGTASPYLPFGAGR
HRCIGEKFAYVNIGVILATLVRHLRLSNMDGKEGVPATDYSSLFSGPMKPSIIQWGKR
SNDLSK
>CYP51F2 Ajellomyces capsulatus NAm1
XM_001540591.1
70% to CYP51F2
Aspergillus fumigatus
MSWFTIGTFGVLAFVAAVTLNLVYQLLFRFLNKTRPPLVFHWIP
FLGSTIRYRTDPYKFFFSCRQKEASRLFQHGDIFTFVLLGRPTTVYLGIKGNEFILNG
KLKDVNAEEVYGPLTTPVFGPDVVYDCPNSKLIEQKKFIKYGLTQAALESHVPLIEKE
VMDYLDSSPNFLGASGEVDISAVMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLDK
GFSPINFMLPWAPLPHNKKRDAAHTLMHAIYLDIIEKRRRAARNANGSQTQDMIENLM
QCTYKNGQKLPDKEIANIMISLLMAGQHSSSTTSSWIMLHLASEPAVVEQLYQEQLDN
LPRTGPNGSLGPLQYGDLNRLPLHRNVIRETLRLHTSIHSLLRKVMNPMPVAGTPYVI
PPSHVVLSAPGVTALSDEYFPNPTMWDPNRWETQEPKVDEKEDMVDYGYGTISKGTSS
PYLPFGAGRHRCIGEKFAYVNLTVIVAIMVRHLQFSNIGGKTGVPRTDYSSMFSAPMK
PARINWKRRTAKSG
>CYP51F2 Histoplasma capsulatum G217B
94% to CYP51F2 Ajellomyces capsulatus NAm1
two identical sequences
ABBT01000205.1 Ajellomyces capsulatus G217B
481620-479996 (-)
ABBT01000207.1 Ajellomyces capsulatus G217B
78633-77009 (-)
HCB05685.1 identical to HCB06140.1
MSWSTIGTFGVLAFVAAVAFNLVYQLLFHFLNKTRPPLVFHWIPFLGSTIRYGTDPYKFFFSCRQKHGDIFTFVLLGRPT
TVYLGIKGNEFILNGKLKDVNAEEVYSTLTTPMFGPDVVYDCPNSKFIEQKKFIKYGLTQEALESHVPLIEKEVMDYLDS
SPNFLGASGEVDISAVMAEITIFTAGSALQGEEVRSKLTAEFAVLYHDLDKGFSPINFMLPWAPLPHNKKRDAARALMHA
IYLDIIEKRRRAARNANGSQTQDMIENLMQCTYKNGQKLPDKEIANIMITLLMAGQHSSSTTSSWIMLHLASEPAVAEQL
YQEQLDNLPRTGPNGSLAPLQYGDLDRLPLHRNVIKETLRLHTSIHSLLRKVMNPMPVAGTPYVIPPSHIVLSAPGVTAL
SDEYFPNPTMWDPNRWETQEPKVDEKEDMVDYGYGAISKGTSSPYLPFGAGRHRCIGEKFAYVNLTVIVAIMVRHLQFSS
IGGKTGVPRTDYSSMFSGPMKPARINWKRRTAKSG
>CYP51F2 Penicillium digitatum strain GL-01
DQ355161.1,
also AJ439081 (5 aa diffs)
67% to
CYP51F2 Aspergillus fumigatus
MDLVPLVTGQIKCIAYYTTGLVLASIVLNVIKQLVFYNRKEPPV
VFHWIPFIGSTVAYGMDPYQFFFASRAKYGNIFTFILLGKKTTVYLGVEGNEFILNGK
LKDVNAEEIYGKLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLSQEALESYVPLIADEI
SSYIKSSPSFKGQSGTIDLVPAMAEITTFTAARTLQGEEVRSKLTTEFAKLFHDLDLG
FTPINFMLPWAPLPQNRKRDRAHRRMREIYVDIIQARREAGEEANDNGRDKTKGTDMI
SNLMRCVYRDGTPIPDKEIAHLMITLLMAGQHSSASISCWILLRLASQPEMTEKLFAE
QVNNLGADLPLLQYKDLDKLPLHRNVIKETLRLHSSIHTLMRKVKNPMPVPGTDFVIP
PSHTLLSSPGVTARDERHFRDPLRWDPHRWGSRVEAEDSSDTVDYRYGAVSKGTRSPY
LPFGAGRHRCIGEKFAYLNLGVIIATLLREFRFFNPEGMEGVPDTDYSSLFSRPMQPA
TVRWEVRS
>CYP51F2 Nectria haematococca fgenesh1_pg.scaffold_7000156
57% to CYP51F1 like seq fgenesh1_pg.scaffold_2000426,
Necha1/scaffold_7:419968-421550
80%
to Fusarium graminearum CYP51F2
FG04092.1
AACM01000179 FGcontig1.179_scaffold2
Note
only one intron, not two as seen in CYP51F1
This gene model seems correct DRN 2/4/06
MLLLVWYPVLAIGAFLGIILIHALRQKLFRKAGEPPLIFHWLPFIGNAVSYGLDPCNFFMKCREK
(0)
HGDVFTFVLFGRKIVCCLGVEGNDFVLNSRLQDANAEEIYGPLTIPVFGSDVVYDCPNSKFMEQKKFVKFGLTQK
ALESHVQLIEREVLDYIHAVPAFSGSEGTVDISNAMAEITIFTAARSLQGEEVRRKLTAEFAALYHDLDL
GFKPVNFLFPWAPLPHNRKRDAAHAKMRDIYMDIINKRRAEGGDLGEYSDMIANLMGCTYKNGQPVPDKE
IAHMMITLLMAGQHSSSSASSWIMFRLASRPDIAEELYQEQLTHLSVDGYLPPLQHSDLDKLTLLQNVVK
ETLRVHSSIHSILRKVKTPMQAPGTQYTITTDKVILASPTVTALSEEYFSNARTWDPHRWDNKEKEEVAG
DDVVDYGYGKVSKGTKSPYLPFGAGRHRCIGEKFAYVNLGVIVATMVRNFKLSTMDGKSGVPATDYNSLF
SRPVQPAYIRWERRKA*
>CYP51F2v1 Aspergillus fumigatus
GenEMBL
AAF32372.1 also AAK73659.1
cytochrome
P450 sterol 14 alpha-demethylase variant
MVPMLWLTAYMAVAVLTAILLNVVYQLFFRLWNRTEPPMVFHWVPFLGSTISYGIDPYKFFFACREKYGD
IFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLT
QSALESHVPLIEKEVLDYLRDSPNFQGSSGRMDISAAMAEITIFTAARALQGQEVRSKLTAEFADLYHDL
DKGFTPINFMLPWAPLPHNKKRDAAHARMRSIYVDIINQRRLDGDKDSQKSDMIWNLMNCTYKNGQQVPD
KEIAHMMITLLMAGQHSSSSISAWIMLRLASQPKVLEELYQEQLANLGPAGPDGSLPPLQYKDLDKLPFH
QHVIRETLRIHSSIHSIMRKVKSPLPVPGTPYMIPPGRVLLASPGVTALSDEHFPNAGCWDPHRWENQAT
KEQENDEVVDYGYGAVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVILATIVRHLRLFNVDGKKGVPETD
YSSLFSGPMKPSIIGWEKRSKNTSK
>CYP51F2v2 Aspergillus fumigatus Af293
GenEMBL
XP_752137.1 also EAL90099.1
14-alpha
sterol demethylase variant
74% to 51F2 A.
nidulans 62% to 51F1 A. nidulans
only 5 aa
diffs to CYP51F2v1, may be another gene or an allele
MVPMLWLTAYMAVAVLTAILLNVVYQLFFRLWNRTEPPMVFHWVPYLGSTISYGIDPYKFFFACREKYGD
IFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLT
QSALESHVPLIEKEVLDYLRDSPNFQGSSGRVDISAAMAEITIFTAARALQGQEVRSKLTAEFADLYHDL
DKGFTPINFMLPWAPLPHNKKRDAAHARMRSIYVDIITQRRLDGEKDSQKSDMIWNLMNCTYKNGQQVPD
KEIAHMMITLLMAGQHSSSSISAWIMLRLASQPKVLEELYQEQLANLGPAGPDGSLPPLQYKDLDKLPFH
QHVIRETLRIHSSIHSIMRKVKSPLPVPGTPYMIPPGRVLLASPGVTALSDEHFPNAGCWDPHRWENQAT
KEQENDKVVDYGYGAVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVILATIVRHLRLFNVDGKKGVPETD
YSSLFSGPMKPSIIGWEKRSKNTSK
>CYP51F2 Aspergillus oryzae
GenEMBL BAE57417.1
77% to CYP51F4,
75% to CYP51F2 Aspergillus nidulans
MASFTLVSAYAAAGLLAIIVLNLLRQLLFRNKTDPPLVFHWIPFLGSTVTYGMDPYAFFFSCRQKYGDIF
TFILLGRKITVYLGIQGNEFILNGKLKDVNAEEIYSPLTTPVFGSDIVYDCPNSKLMEQKKFIKFGLTQA
ALESHVPLIEKEVLDYLKTSPNFKGTSGRVEITDAMAEITIFTAGRALQGEEVRKKLTTEFADLYHDLDR
GFTPINFMLPWAPLPRNRKRDAAHARMREIYMDIINERRKNPDRETSDMIWNLMHCTYKNGQPLPDKEIA
HMMITLLMAGQHSSSSISSWIMLRLASEPAVMEELYQEQITKLSPDGRTLPPLQYRDLDLLPLHQNLIKE
TLRLHLSIHSLMRKVKNPMPVPGTPYVVPADHVLLASPGVTALSDEYFPNASRWDPHRWENRVEKEDEED
IVDYGYGTVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVIVATMARHMKLFNVDGKKGVPATDYSSMFSG
PSKPAIIGWERRFPEKS
>CYP51F2 Aspergillus flavus
99% to CYP51F2 Aspergillus oryzae, 1 aa diff
AFL2G_02771
MASFTLVSAYAAAGLLAIIVLNLLRQLLFRNKTDPPLVFHWIPFLGSTVTYGMDPYAFFFSCRQKYGDIFTFILLGRKIT
VYLGIQGNEFILNGKLKDVNAEEIYSPLTTPVFGSDIVYDCPNSKLMEQKKFIKFGLTQAALESHVPLIEKEVLDYLKTS
PNFKGTSGRVEITDAMAEITIFTAGRALQGEEVRKKLTAEFADLYHDLDRGFTPINFMLPWAPLPRNRKRDAAHARMREI
YMDIINERRKNPDRETSDMIWNLMHCTYKNGQPLPDKEIAHMMITLLMAGQHSSSSISSWIMLRLASEPAVMEELYQEQI
TKLSPDGRTLPPLQYRDLDLLPLHQNLIKETLRLHLSIHSLMRKVKNPMPVPGTPYVVPADHVLLASPGVTALSDEYFPN
ASRWDPHRWENRVEKEDEEDIVDYGYGTVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVIVATMARHMKLFNVDGKKGVP
ATDYSSMFSGPSKPAIIGWERRFPEKS*
>CYP51F2 Neosartorya fischeri NRRL 181
XM_001267337.1, NFIA_109350
97% to CYP51F2
Aspergillus fumigatus
MVPMLLLTAYMAVAMLTAILLNVVYQLFFRLWNRTEPPMVFHWV
PFLGSTISYGIDPYKFFFACREKYGDIFTFILLGQKTTVYLGVQGNEFILNGKLKDVN
AEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLTQSALESHVPLIEKEVLDYLR
NSPNFQGSSGQVDISAAMAEITIFTAARALQGQEVRSKLTAEFADLYHDLDKGFTPIN
FMLPWAPLPHNKKRDAAHARMRSIYIDIINQRRLDGEKDSQKSDMIWNLMNSTYKNGQ
QVPDKEIAHMMITLLMAGQHSSSSISAWIMLRLASQPKVLEELYQEQLANLGPVGPDG
SLPPLQYKDLDKLPFHQHVVRETLRLHSSIHSLMRKVKSPLPVPGTPYMIPPGRVLLA
SPGVTALSDEHFPNAGCWDPHRWENQAAKEQENDEVVDYGYGAVSKGTSSPYLPFGAG
RHRCIGEKFAYVNIGVILATIVRHLRLFNVDGKKGVPETDYSSLFSGPMKPSIIGWEK
RSKDTSK
>CYP51F2 Magnaporthe grisea MG04628.4 62% to CYP51 Penicillium AACU01001139
cont2.870
MAFFFPSAPVWVYSAGAALLFIIGSIILNFIWQQLPRPKSEPPLVFHWLP
FIGNAVSYGMDPYRFYSQCREKHGDVFTFVLFGRRMTVFLGVQGNDFILN
GKLQDLNAEEIYSPLTTPVFGSDIIYDCPNSKLMEQKKFVKFGLTQKALD
SYVPLIEREVLDYIESSPVFQAGNHGIVDIPSMMAEITIFTASRTLQGPE
VRKKLTGEFARLYHDLDLGFRPINFLAPWAPLPQNRRRDVAHARMRDVYM
DLINKRRRQKDDQEEEEEAEPDMIRHLMGSCVYKNGQALPDKEIAHMMIT
LLMAGQHSSSSSSAWIMLRLASRPDIAEEVYQEVQRLGHASLQHSDLDKL
PLLANVVKETLRVHSSIHSIMRKVKRPMRIPGSDYVVTPGKVLVSAPIMT
HLDEEHFRDARAWEPHRWDDAVDAQDDEIVDYGYGATSKGTKSPYLPFGA
GRHRCIGEKFAYLNLAAIVSTLVRNFKFSTLDGKATVPPTDYTSMFSRPM
QPATVRWERRSPKTA*
>CYP51F2 Fusarium oxysporum
83% to CYP51F2 Fusarium graminearum
FOXG_11545
MFSLLYYPLWAFASCLVIITLNVLYQKLPRNANEPPLVFHWLPFVGNAVAYGLDPYGFFVKCREK
HGDVFTFILFGRKIV
ACLGVDGNDFVLNSRIQDANAEEIYSPLTTPVFGSDVVYDCPNSKLMEQKKFVKFGLTQKALESHVQLIEREVLEYIQAV
PSFSGKSGTVDVSKAMAEITIFTAARSLQGEEVRRKLTAEFAALYHDLDLGFTPVNFLFPWLPLPHNRRRDAAHAKMREI
YMDIINGRRRGVGDLEKGTDMIANLMNCEYKNGQPIPDKEIAHMMITLLMAGQHSSSSASSWIILHLASSTDIAEELYQE
QLINLSADGVLPPLQYTDLDKLPLLQNVVKETLRVHSSIHSILRKVKRPMQAPGSPYTITTDKVLLASPTVTALSEEHFT
DAQRWNPHRWDNKPQEEAVTDDVIDYGYGAVSKGTKSPYLPFGAGRHRCIGEKFAYVNLGVIVATLVRNFRLSTLDGKPG
IPATDYTSLFSRPAQPAYINWERRRA*
>CYP51F2 Fusarium verticillioides
94% to CYP51F2 Fusarium oxysporum
FVEG_10277
MFSLLYYPLWAFASCLAIITLNVLYQKLPRNANEPPLVFHWLPFFGNAVAYGLDPYGFFVKCREK
(0)
HGDVFTFVLFGRKIVACLGVDGNDFVLNSRIQDANAEEIYGPLTTP
VFGSDVVYDCPNSKLMEQKKFVKFGLTQKALESHVQLIEREVLEYIQAVP
SFSEKSGTVDVSKAMAEITIFTAARSLQGEEVRRKLTAEFAALYHDLDLGFT
PVNFLFPWLPLPHNRRRDAAHSKMREIYMGIINERRRGGGDLEKRTDM
IANLMSCAYKNRQPIPDKEIAHMMITLLMAGQHSSSSASSWIVLHLASSPDI
TEELYQEQVINLSASGALPPLQYSDLDKLPLLQNVVKETLRVHSSIHS
ILRKVKRPMQAPGPPYTITTDKVILASPTVTALSEEHFPDAQRWNPHRWDNKP
QEEAVTDEVIDYGYGAVSKGTKSPYLPFGAGRHRCIGEKYAYVNLGV
IVATLVRNFRLSTLDGKPGVPATDFTSLFSRPAQPAYIKWERRKA
>CYP51F3 Fusarium graminearum FG11024.1
AACM01000457 FGcontig1.457_scaffold8
MESLYETLRTLPLSVSIPLTTSIIIILSIVTNVVKQLWFPNPHRPPVVFH
IFPFIGSTVQYGIDPYAFFFDCRDKYGDCFTFILLGKSTTVFLGPKGNDF
ILNGKHADLNAEDVYGKLTTPVFGEEVVYDCSNARFMDQKRLLKLGLTTD
SLRCYIPKFVKEVEDYVKNSPYFKGDTGIVNITEVMAEITIYTASGSLLG
NEVRSMFDSTFATLYRHLDDGFQPINFVMPGLPLPQNFRRNHARKVMEKL
FSDIISKRRETGNQGDETDMIWMLMNAQYKDGEPLPDHHAARMLIAILMG
GQHNTAVSGAWLLLNLAHKPHLVQELYEEQTQVLGSPQEPLTWENLQKLT
LNGQVIKETLRLHSPIHSILRQVKSPMRVPGTEWVVPPSHTLLSSPGTMA
RSEEFFPRPSEWDPHRWDKIEPLVKTAEDGQTVDYGFGVMSKSVSSPYLP
FGAGRHRCVGENYAYAQLGAIVATFIRLVHIEQPDPKAPLPAPDYSSMFS
RPMNPAEIRWRRRETVE*
>CYP51F3 Nectria haematococca fgenesh1_pg.scaffold_6000765
52% to fgenesh1_pg.scaffold_2000426,
Necha1/scaffold_6:2267196-2268844
81% to Fusarium graminearum CYP51F3
FG11024.1 AACM01000457 FGcontig1.457_scaffold8
Note two exons, but the second exon is not seen
in CYP51F1 or CYP51F2
This gene model seems correct DRN 2/4/06
MESLYGSFRALPLSISIPFTVGLVVVIAIARNVIGQLYFPDRNRPPVVFHVFPFIGSSVQYGIDPYKFFF
DCKAKYGDCFTFILLGKPTTVFLGQKGNEFILNGKHADLNAEEVYGKLTTPVFGKEVVYDCSNARFMDQKR
(0)
LLKLGLTTEALRAYIPKFVKEVEDYVNTSPYFKGETGQVNITEVMAEITIYTASGSLLGNEVRSMFDST
FALLYRHLDDGFQPINFVMPWLPLPQNRRRDHARNVMEGLFANIIRQRREQGNQGDETDMIWTLMDAQYK
DGTVLPDIHVARLLIAILMGGQHNTAASGAWLFLNLAHKPHLVEEMYQEQLEVLGSPPAPLTWENVQKLT
LNGQVIKETLRLHSPIHSIMREVKSPMPVPGTEWVVPPSHTLLASPGTLARSEDFFPRPLEWDPHRWDKA
DPVEGPVDDSQKVDYGFGMMSKAVSSPYLPFGAGRHRCVGEHYAYAQLGAIVATFVRLCHMEQVDPKAPI
PATDYS (1)
SMFSRPMNPAVIKWRRRKPE*
>CYP51F3 Fusarium oxysporum
87% to CYP51F3 Fusarium graminearum
FOXG_13138, note: gc boundary at DQKR
MEALYSNWRSFPLSLSVPITAFLIIAIATITNVIKQLWFPNPHRPPVVFHIFPLIGSTVQ
YGIDPYKFFFDCQAKYGDCFTFILLGKSTTVFLGPKGNDFILNGKHADLNAEDVYGKLTT
PVFGKEVVYDCSNARF MDQKR (0)
LLKLGLTTDSLRCYIPKFVKEVEEYIATSPYFKGSTGIVNITEVMAEITIYTAAGSLLGNEVRSMFDSTFATLYR
HLDDGFQPINFVMPGLPLPQNFRRDHARKVMEELFSDIIRKRREIGNQGGETDMVWTLMNAKYKDGEDLPDHHAARMLIA
ILMGGQHNTAASGAWLLLNLAHKPHLVQELYDEQLEVLGSPQEPLTWENLQKLTLNGQVIKETLRLHSPIHSILRQVKSP
MRVPGTDWVVPPSHTLLASPGTQARSEEFFPRPMEWDPHRWDKIESLEDSKGNGETVDYGFGVMNKSVSSPYLPFGAGRH
RCVGENYAYAQLGAIIATFVRLLHIEQPDPNAPLPAPDYSSMFSRPMNPAVIRWTRRNTEAN*
>CYP51F3 Fusarium verticillioides
95% to CYP51F3 Fusarium oxysporum
FVEG_12391
MDALYTNWRSLPLSLSIPITAFLIIVIATITNVIKQLWFPNPHRPPVVFHIFPLIGSTVQ
YGIDPYKFFFDCQAKYGDCFTFILLGKSTTVFLGPKGNDFILNGKHADLNAEDVYGKLTT
PVFGREVVYDCSNARF
MDQKRLLKLGLTTESLRCYIPKFVKEVEDYIATSPYFKGNTGIVNITEVMA
EITIYTAAGSLLGNEVRSMFDSTFATLYRHLDDGFQPINFVMPGLPLPQ
NFRRDHARKVMEELFSDIIRKRREMGNQGDETDMVWTLMNAKYKDGEDLPN
HHAARMLIAILMGGQHNTAASGAWLLLNLAHKPHLVKELYDEQVEVLGS
PQEPLTWENLQKLTLNGQVIKETLRLHSPIHSILRQVKSPMRVPGTDWVV
PPSHTLLASPGTQARSEEFFPRPMEWDPHRWDKIESLDDAKNGETVDYGF
GMMSKSVSSPYLPFGAGRHRCVGENYAYAQLGAIIASFVRLLHIEQPDPK
APLPAPDYSSMFSRPMNPAVIRWTRRNAETG
>CYP51F4 Aspergillus oryzae
GenEMBL BAE63554.1
72% to 51F2
Aspergillus nidulans, 77% to 51F2 Aspergillus oryzae
60% to 51F1
Aspergillus oryzae
MSWPRIGAYALLAFVAIMALNVTYQFLFRMLNKTRPPLVFHWIPFIGSTIHYGTDPYGFFFSCREKYGDI
FTFILLGRPTTVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQ
AALEAHVPLIEKEVEDYLAMSPNFHGTSGEVDIPAAMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLD
KGFTPINFMLPWAPLPHNKKRDAAHARMRAIYIDIINKRRNAGDNVPEKLDMIGNLMQCTYKNGQPLPDK
EIAHIMITLLMAGQHSSSSISSWIMLRLASQPAVVEELYQEQLANLERTGPNGSLAPLQYKDFDNLPLHQ
NVIRETLRLHSSIHSLLRKVKNPLPVPGTPYVIPTSHVLLAAPGVTALSDEYFPNAMAWDPHRWETQAPQ
ENNKDDIVDYGYGAMSKGTSSPYLPFGAGRHRCIGEKFAYLNLAVIVATMVRHLRFSNLDGQTGVPDTDY
SSLFSGPMKPARIRWERRAAKSG
>CYP51F4 Aspergillus flavus
99% to CYP51F4 Aspergillus oryzae
AFL2G_10953
MSWPRIGAYALLAFVAIMALNVTYQFLFRMLNKTRPPLVFHWIPFIGSTIHYGMDPYGFFFSCREKYGDIFTFILLGRPT
TVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQAALEAHVPLIEKEVEDYLAM
SPNFHGTSGEVDIPAAMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLDKGFTPINFMLPWAPLPHNKKRDAAHARMRS
IYIDIINKRRNAGDNVPEKLDMIGNLMQCTYKNGQPLPDKEIAHIMITLLMAGQHSSSSISSWIMLRLASQPAVVEELYQ
EQLANLERTGPNGSLAPLQYKDFDNLPLHQNVIRETLRLHSSIHSLLRKVKNPLPVPGTPYVIPTSHVLLAAPGVTALSD
EYFPNAMAWDPHRWETQAPQENNKDDIVDYGYGAMSKGTSSPYLPFGAGRHRCIGEKFAYLNLAVIVATMVRHLRFSNLD
GQTGVPDTDYSSLFSGPMKPARIRWERRAAKSG*
>CYP51F5 P450-46 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
62% to P450-40
42% to CYP51F1 Ustilago maydis in the CYP51
family
45% to CYP51F1 S. pombe
RO3G_16595.1
MAIISTLLSETSLSSLLYKAIVFLATYYVIHLLSQFQPKDPKAVPLVPSWIPFFGNAIEFGKNPIEFLQTCQKKYGDVFTFRLLNKRVTACLGPDGNQFVFNAKQEVASAAAAYNHMTKYVFGNDIVFDTAHSVFMEQKRMIKSGLNIEAFRKDVPLIIEECDAFFDGLEPQGEMDLYKMFGTLIIYTASRTLLGPEIRQALDSGVSELYYDLDQGFRPINFMFPNLPLPSYRRRDEAREKLAKIYAGIIQKRRQSEHGESDLLQTLIEARYKDGSAVPDAQICGILTAALFGGQHTSSTTAAWTILELAQRPDIIQALRQEMITQCGSLEVDFTYDHLERLTLLEHVVKETLRLHPPIFNMMRRVVAPKCVFSGREIPQGDYLLAAPGVTQLDPHYFHQPTVWDPYRWSQLKDPVHQLEQGEDANADYGFGVVGISSKSPFLPFGAGRHRCIGEKFGYLQLKTIIGTFVKRFDVEPLSHTVPKPDYTSMVVVPENSHIRYRARKQ
>CYP51F6 Kluyveromyces polysporus
Kpol_1023p61
65% to CYP51F1 S. cerevisiae
MELVKSLLLFIISFSFWQIVTIIIVTPLAYNIFWQVYESFRTDRPPLVMHWVPWVGNYASYNLKPYKFLQDCQKKHGDIF
SFVMLGQIITVYLGPNGNDFIFNANVDEVSAKDVYSRMTTPVFGKGVIYDCDHDKLIEQKRFVKKALTIESLKKYVPLIQ
DEIQKYFTNSKFFRLGKYNSGITNVMATQPEMTIFTSSRTLLGEQLRKKLDTDFAYLYSDLDKGFTPINFVFKNLPLEHF
RSRDNAHKLISTTYLSLIKERRATNDIKDRDLIDSLLKNSTYKDGTKMTDQEIANLLIGVLMGGQHTSAATSAWFLLHLA
EKPQIQEELYKEVMEVLDNGRLPLTYESLQKMKLVNQTIRETLRLHHPLHSLFRKVRKNIPIPRTNYIIPKHRLLLVSPG
YTHLQDKYFPNAKEFDIHRWSDNQINESVEHIDYGFGKISKGTSSPYLPFGGGRHRCIGEDFAYCQLGTLLVTFVTKIKW
SLPENKAIPETDYQSMVTLPLGSAHILWEKR
>CYP51F7 Uncinocarpus reesii
58% to CYP51F
Uncinocarpus reesii from PPVV on
62% to Aspergillus terreus CYP51F1
UREG_00593.1, model is short. Seq. runs into a
gap, missing last exon
MESFLVFSPTTQLLPAVLIVGVLTVFIGNLLLQFSSRGGAK
PPVVFHWVPFVGSAISYGLDPYRFFASCREK ()
YGDIFTFVLLGRKITVYLGVKGNDFILNGKLQDVNAEEVYSPLTTPVFGSDVIYDCPNQKLMEQKK
FIKFGLSSEALASYVPLIQHEVEQYIATSPHFRGESGTVNIAQ
IMAEITILTAARTLQGEEVRSKLDSSFANYYHDLDAGFTPINFLLPWAPLPHNRKRDAAH
KKMRDVYMGIIKQRRASGQTRGHDMLWNLMDNCVYKDGSALPDKEIAHIMITLLMAGQHT
SSAVSSWAMLQLAAHPEIGEDLYQEQIRVLESSQALTLRDIDRLTLNQMVLKETLRLHSP
IHSIMRKAKNTMSIPGTDLVVPESHILLSAPGFTARSEDHFRDAVEWNPRRWLSAPEPSE
DDDEKIDYGYGVTMKGTKGPYLSFGGGRHRCIGEKFAYLNLG (1)
>CYP51F7 CIMG_00573.2 Coccidioides immitis
84% to CYP51F7 Uncinocarpus reesii (ortholog to second CYP51 in this
species)
CIMG_00573.2
MESLPFPSPTVQLLPTVVIIGVLSIFIGNLLRQFAPHRGAKPPVVFHWVPFIGSAISYGLDPYRFFTSCREKYGDIFTFV
LLGRKVTVYLGVKGNEFILNGKLQDVNAEEVYSPLTTPVFGSDVIYDCPNQKLMEQKKFIKFGLSSEALASYVPLIQHEV
EQYIASSPHFKGESGTMNVLQVMAEITILTAARTLQGEEVRSKLDSSFANYYHDLDSGFTPINFLLPWAPLPHNRKRDAA
HKKMRDVYMDIIKKRRISGQERGHDMLWNLMDNCVYKDGTALPDKEIAHLMITLLMAGQHTSSAISAWAILQLAAHPEVM
EGLYQEQVQVFGPSKSITLGDIDRLSFSQMVIKETLRLHAPIHSIMRKAKNTMAVPGTNLVIPESHILLSAPGFTARSED
HFKDAAKWNPHRWLSVIERSEADEKIDYGYGVTIKGTKSPYLPFGAGRHRCIGEKFAYVNLGVILAVMVRHFKLRNPDNR
VGVPATDYRSLLSRPMEPSSVHWEKRNFVSE
>CYP52A1
Candida tropicalis M24894
MSSSPSIAQEFLATITPYVEYCQENYTKWYYFIPLVILSLNLIS
MLHTKYLERKFKAKPLAVYVQDYTFCLITPLVLIYYKSKGTVMQFACDLWDKNLIVSD
PKAKTIGLKILGIPLIETKDPENVKAILATQFNDFSLGTRHDFLYSLLGDGIFTLDGA
GWKHSRTMLRPQFAREQVSHVKLLEPHMQVLFKHIRKHHGQTFDIQELFFRLTVDSAT
EFLLGESAESLRDESVGLTPTTKDFDGRNEFADAFNYSQTNQAYRFLLQQMYWILNGS
EFRKSIAIVHKFADHYVQKALELTDEDLEKKEGYVFLFELAKQTRDPKVLRDQLLNIL
VAGRDTTAGLLSFLFFELSRNPEIFAKLREEIENKFGLGQDARVEEISFETLKSCEYL
KAVINETLRIYPSVPHNFRVATRNTTLPRGGGEGGLSPIAIKKGQVVMYTILATHRDK
DIYGEDAYVFRPERWFEPETRKLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEF
GNLKQDPNTEYPPKLQNTLTLSLFEGAEVQMYLIL
>CYP52A2 C.
tropicalis X17560
ISLLNILVAGRDTTAGLLSFVFFELARTPRVANKLREEIEDKFG
LGQDARVEEISFESLKSCEYLKAVLNECLRLYPSVPQNFRVATRNTTLPRGGGKDGLS
PVLVRKGQTVMYSVYAAHRNKQIYGEDALEFRPERWFEPETKKLGWAFLPFNGGPRIC
LGQQFALTEASYVTVRLLQEFSHLTMDPNTEYSPKKMSHLTMSLFDGANIQMY
>CYP52A3
Candida maltosa P450cm1. X51931
MAIEQIIEEVLPYLTKWYTIIFGAAVTYFLSIALRNKFYEYKLK
CENPVYFQDAGLFGIPALIDIIKVRKAGQLADYTDTTFDKYPNLSSYMTVAGVLKIVF
TVDPENIKAVLATQFNDFALGARHAHFDPLLGDGIFTLDGEGWKHSRAMLRPQFAREQ
IAHVKALEPHVQILAKQIKLNKGKTFDLQELFFRFTVDTATEFLFGESVHSLYDEKLG
IPAPNDIPGRENFAEAFNTSQHYLATRTYSQIFYWLTNPKEFRDCNAKVHKLAQYFVN
TALNATEKEVEEKSKGGYVFLYELVKQTRDPKVLQDQLLNIMVAGRDTTAGLLSFAMF
ELARNPKIWNKLREEVEVNFGLGDEARVDEISFETLKKCEYLKAVLNETLRMYPSVPI
NFRTATRDTTLPRGGGKDGNSPIFVPKGSSVVYSVYKTHRLKQFYGEDAYEFRPERWF
EPSTRKLGWAYLPFNGGPRICLGQQFALTEASYVIARLAQMFEHLESKDETYPPNKCI
HLTMNHNEGVFISAK
>CYP52A4
Candida maltosa ALK3-A X55281
MPVSFVHNVLEVVTPYVEYYQENLTKWYILIPTILLTLNFLSIL
HTKYLEYKFNAKPLTNFAQDYSFGVITPLMLMYFKWHGTVMEFACNVWNNKFLVLNGN
VRTVGLRIMGLNIIETTDPENVKAILATQFNDFSLGTRHDFLYSLLGDGIFTLDGAGW
KHSRAMLRPQFAREQVAHVKLLEPHVQVLFKHVRKSQGKTFDIQELFFRLTVDSSTEF
LFGGSVESLRDASIGMTPSTKNIAGREEFADAFNYSQTYNAYRFLLQQFYWILNGSKF
NKSIKTVHKFADFYVQKALSLTEADLEKQEGYVFLYELAKQTRDPKVLRDQLLNILVA
GRDTTAGLLSFLFFELSRNPTVFEKLKEEIHNRFGAKEDARVEEITFESLKLCEYLKA
CVNEALRVYPSVPHNFRVATRNTTLPRGGGKDGMSPIAIKKGQNVMYTILATHRDPNI
YGEDANVFRPERWFEPETRKLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEFHT
LTQDADTRYPPRLQNSLTLSLCDGANIQMY
>CYP52A5
Candida maltosa ALK2-A X55281
MTSDSTIHELIQSYITKWYVIVPLAIIIYKVFDYFYVLSLRKRL
GAAVPTNEETDGYFGFHLPFVLMSKKKDGTIIDFSIERYPELKHPETPTFEFPIFTVK
LISTIDPENIKAILATQFSDFSLGTRHAHFAPLIGDGIFTLDGAGWKHSRAMLRPQFA
REQVGHVKLLEPHVQVLFKHIRKNKGREFDLQELFFRFTVDSATEFLFGESVESLRDA
SIGMTSKSKDVDGIEDFTGAFNYSQNYLASRSIMQQFYWILNGKKFRECNAIVHKFAD
HYVQKALNLTEADLEKQAGYVFLYELVKQTRDPQVLRDQLLNILVAGRDTTAGLLSFV
FFELARNPDVVAKLKDEIDTKFGLGEDARIEEITFESLKQCEYLKAVLNECLRLYPSV
PQNFRVATKNTTLPRGGGKDGLSPILVRKGQTVMYSVYATHRMESVYGKDATTFRPER
WFEPETRKLGWAFVPFNGGPRICLGQQFALTEASYVTVRLLQEFSTLTLDPNLEYPPK
KMSHLTMSLFDGTNVQMY
>CYP52A6
C.tropicalis alk3 Z13010
MATQEIIDSALPYLTKWYTVITLAALVFLISSNIKNYVKAKKLK
CRDPPYFKGAGWTGISPLIEIIKVKGNGRLARFWPIKTFDDYPNHTFYMSIIGALKIV
LTVIQENIKAVLATQFTDFSLGTRHAHFYPLLGDGIFTLDGEGWKHSRAMLRPQFARD
QIGHVKALEPHIQILAKQIKLNKGKTFDIQELFFRFTVDTATEFLFGESVHSLYDEKL
GIPTPNEIPGRDNFATAFNTSQHYLATRTYSQTFYFLTNPKEFRDCNAKVHYLAKYFV
NKALNFTPEEIEEKSKSGYVFLYELVKQTRDPKVLQDQLLNIMVAGRDTTAGLLSFAM
FELARHPEIWSKLREEIEVNFGVGEESRVEEITFESLKRCEYLKAILNETLRMYPSVP
VNSRTATRDTTLPRGGGPNGTDPIFIPKGSTVAYIVYKTHRLEEYYGKDADDFRPERW
FEPSTKKLGWAYVPFNGGPRICLGQQFALTEASYVITRLVQMFETVSSPPDVEYPPPK
CIHLTMSHDDGVFVKM
>CYP52A7
C.tropicalis alk4 Z13011
MIEQVLHYWYYVLPAFIIFHWIVSAIHTNSLRRKLGAKPFTHTQ
LDGFYGFKFGRDFLKAKRIGRQVDLINSRFPDDIDTFSSYTFGNHVIFTRDPENIKAL
LATQFNDFSLGGRIKFFKPLLGYGIFTLDGEGWKHSRAMLRPQFAREQLPMSPSLEPH
FNVKAYPQEQRWVFDIQELFFRFTVDSATEFLFGESVNSLKSASIGCDEETELEERKK
FAEAFNKAQEYISTRVALQQLYWFVNNSEFKECNEIVHKFTNYYVQKALDATPEELEK
QSGYVFLYELVKQTRDPNVLRDHHSISLLAGRDTTAGLLSFAVFELARNPHIWAKLRE
DVESQFGLGEESRIEEITFESLKRCEYLKAVMNETLRLHPSVPRNARFALKDTTLPRG
GGPDGKDPILVRKMSCSIFISGTQIDPKHYGKDAKLFRPERWFESSTRNLGWAYLPFN
GGPRICLGQQFALTEAGYILVRLAQSFDTLELKPDTEYLTKISHLTMCLFGAFVKMD
>CYP52A8
C.tropicalis alk5 Z13012
MYEQVVEYWYVVLPLVFILHKVFDMWHTRRLMKQLGAAPVTNQL
HDNFFGIINGWKHLSSRKKVELKNIMIINLPIRKFQVWVHMLVPSLEQSSSSQKIRRN
IKALLATQFSDFSLGKRHTLFKPLLGDGIFTLDGQGWKHSRAMLRPQFAREQVAHVTS
LEPHFQLLKKHMVKNKGGFFDIQELFFRFTVDSATEFLFGESVHSLKDETIGSYQDDI
DFVGRKDFAESFNKAQEYLAIRTLVQDFYYLVNNQEFRDCNKLVHKFTNYYVQRALDA
TPEELEKQSGYVFLYELVKQTRGPNVLRDQSLNILLAGRDTSAGLLSFAVFELARNPH
IWAKLREDVESQFGLGEQSRIEEITFESLKRCGYLKAFLNETLRVYPSVPRNFRIATK
NTTLPRGGGSDGNSPVLVKKGEAVSYGINSTHLDPVYYGDDAAEFRPERWNEPSTRKL
GWAYLPFNGGPRICLGQQFALTEAGYVLVRLAQSFDTLELKPPVVYPPKRLTNLTMSL
QDGTIVKID
>CYP52A9
Candida maltosa D12717
MIDEILPKLVQYWYIVLPTLLIIKHVVSYINTQRLMRKFRAKPV
TNVLNDGFFGIPNGIKAIKEKNKGRAQEYNDEKFAAGPKPKVGTYLFKLFTKDVLVTK
DPENIKAILATQFEDFSLGKRLDFFKPLLGYGIFTLDGEGWKHSRAMLRPQFAREQVG
HVKLIEPHFQSLKKHIIKNKGQFFDIQELFFRFTVDSATEFLFGESVESLKDESIGYD
QQDFDFDGRKNFAEAFNKAQEYLGTRAILQLFYWLVNGADFKKSVAEVHKFTDYYVQK
ALDATPEELEKHSGYIFLYELVQQTRDPKVLRDQSLNILLAGRDTTAGLLSFALFELA
RNPEVWSRLREEIGDKFGLDEDATIEGISFESLKQCEYLKAVVNECLRMYPSVPRNFR
IATKHTTLPRGGGPDGKDPIFIKKGAVVSYGINSTHLDPMYYGPDARLFNPDRWSKPE
TKKLGWAFLPFNGGPRICLGQQFALTEASYVLVRMIQNFKELELTPNTVYPPRRLTNL
TMSLYDGAYIKVN
>CYP52A10
Candida maltosa D12719
MIFTAFILDYWYFTLLFLIAAYFIGKHVYTNYLMRKHHAEPILD
VVDDGAFGFKFGFQSLKAKKIGNQIDLLFLKFNEAKHPSIGTFVTRSFGMQFIATKDP
ENIKAMLATQFNEYTLGQRLNFLAPLLGKGIFTLDGNGWKHSRAMLRPQFSRDQIGHV
KMLEPHFQLLKKHIIKNKGTFFDIQELFFRFTVDSATEFLFGESVSSLKDESIGYDQE
EIDFAGRKDFAEAFNKSQVYLSTRTLLQLLYWLVNSADFKRCNKIVHKFSDYYIKKAL
TATPEELEKHSSYIFLYELAKQTRDPIVLRDQSLNILLAGRDTTAGLLSFAVFELGRN
PEVWSKLRQEIGHKFGLDSYSRVEDISFELLKLCEYLKAVLNETLRLYPSVPRNARFA
AKNTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYYGKDANEFRPERWFEPEVR
KLGWAFLPFNGGPRICLGQQFALTEASYVLARLIQSFETLELSPEAAYPPAKLSHLTM
CLFDGTPVRFE
>CYP52A11
Candida maltosa D12719
MVFTAFILEYWYFTLLSLAAGHFIGKHVYTNYLMRKHHAEPILD
VVDDGAFGFKFGFQALKAKKIGKQIDLLFKKFNEAKHPSIGTFVTRSFGMQFIATKDP
ENIKAMLATQFNDFTLGQRLSYFAPLLGKGIFTLDGEGWKHSRAMLRPQFSRDQVGHV
KMLEPHFQLLKKHIIKNKGSFFDIQELFFRFTVDSATEFLFGESVSSLKDESIGYDQE
EIDFAGRKDFAEAFNKSQVYLSTRSLLQLLYWLVNSSDFKRCNKIVHKFSDYYIKKAL
TATPEELEKHSSYIFLYELAKQTRDPIVLRDQSLNILLAGRDTTAGLLSFAVFELGRN
PEVWSKLREEIGDKFGLDPDSRIEDISFELLKLCEYLKAVINETLRLYPSVPRNGRFA
AANTTLPHGGGPDGMSPILVRKGQTVMYSVYALQRDEKYYGKDANEFRPERWFEPEVR
KLGWAFLPFNGGPRICLGQQFALTEASYVLVRLIQSFETLELSPDAPYPPAKLTHLTM
CLFDGAPVRIE
>CYP52A12 Candida tropicalis
AY230498
MATQEIIDSVLPYLTKWYTVITAAVLVFLISTNIKNYVKAKKLK
CVDPPYLKDAGLTGISSLIAAIKAKNDGRLANFADEVFDEYPNHTFYLSVAGALKIVM
TVDPENIKAVLATQFTDFSLGTRHAHFAPLLGDGIFTLDGEGWKHSRAMLRPQFARDQ
IGHVKALEPHIQIMAKQIKLNQGKTFDIQELFFRFTVDTATEFLFGESVHSLYDEKLG
IPTPNEIPGRENFAAAFNVSQHYLATRSYSQTFYFLTNPKEFRDCNAKVHHLAKYFVN
KALNFTPEELEEKSKSGYVFLYELVKQTRDPKVLQDQLLNIMVAGRDTTAGLLSFALF
ELARHPEMWSKLREEIEVNFGVGEDSRVEEITFEALKRCEYLKAILNETLRMYPSVPV
NFRTATRDTTLPRGGGANGTDPIYIPKGSTVAYVVYKTHRLEEYYGKDANDFRPERWF
EPSTKKLGWAYVPFNGGPRVCLGQQFALTEASYVITRLAQMFETVSSDPGLEYPPPKC
IHLTMSHNDGVFVKM
>CYP52A13 Candida tropicalis
AY230499
MTVHDIIATYFTKWYVIVPLALIAYRVLDYFYGRYLMYKLGAKP
FFQKQTDGCFGFKAPLELLKKKSDGTLIDFTLQRIHDLDRPDIPTFTFPVFSINLVNT
LEPENIKAILATQFNDFSLGTRHSHFAPLLGDGIFTLDGAGWKHSRSMLRPQFAREQI
SHVKLLEPHVQVFFKHVRKAQGKTFDIQELFFRLTVDSATEFLFGESVESLRDESIGM
SINALDFDGKAGFADAFNYSQNYLASRAVMQQLYWVLNGKKFKECNAKVHKFADYYVN
KALDLTPEQLEKQDGYVFLYELVKQTRDKQVLRDQLLNIMVAGRDTTAGLLSFVFFEL
ARNPEVTNKLREEIEDKFGLGENASVEDISFESLKSCEYLKAVLNETLRLYPSVPQNF
RVATKNTTLPRGGGKDGLSPVLVRKGQTVIYGVYAAHRNPAVYGKDALEFRPERWFEP
ETKKLGWAFLPFNGGPRICLGQQFALTEASYVTVRLLQEFAHLSMDPDTEYPPKKMSH
LTMSLFDGANIEMY
>CYP52A14 Candida tropicalis
AY230500
MTAQDIIATYITKWYVIVPLALIAYRVLDYFYGRYLMYKLGAKP
FFQKQTDGYFGFKAPLELLKKKSDGTLIDFTLERIQALNRPDIPTFTFPIFSINLIST
LEPENIKAILATQFNDFSLGTRHSHFAPLLGDGIFTLDGAGWKHSRSMLRPQFAREQI
SHVKLLEPHMQVFFKHVRKAQGKTFDIQELFFRLTVDSATEFLFGESVESLRDESIGM
SINALDFDGKAGFADAFNYSQNYLASRAVMQQLYWVLNGKKFKECNAKVHKFADYYVS
KALDLTPEQLEKQDGYVFLYELVKQTRDRQVLRDQLLNIMVAGRDTTAGLLSFVFFEL
ARNPEVTNKLREEIEDKFGLGENARVEDISFESLKSCEYLKAVLNETLRLYPSVPQNF
RVATKNTTLPRGGGKDGLSPVLVRKGQTVMYGVYAAHRNPAVYGKDALEFRPERWFEP
ETKKLGWAFLPFNGGPRICLGQQFALTEASYVTVRLLQEFGHLSMDPNTEYPPRKMSH
LTMSLFDGANIEMY
>CYP52A15 Candida tropicalis
AY230501
MSSSPSFAQEVLATTSPYIEYFLDNYTRWYYFIPLVLLSLNFIS
LLHTRYLERRFHAKPLGNFVRDPTFGIATPLLLIYLKSKGTVMKFAWGLWNNKYIVRD
PKYKTTGLRIVGLPLIETMDPENIKAVLATQFNDFSLGTRHDFLYSLLGDGIFTLDGA
GWKHSRTMLRPQFAREQVSHVKLLEPHVQVFFKHVRKHRGQTFDIQELFFRLTVDSAT
EFLFGESAESLRDESIGLTPTTKDFDGRRDFADAFNYSQTYQAYRFLLQQMYWILNGS
EFRKSIAVVHKFADHYVQKALELTDDDLQKQDGYVFLYELAKQTRDPKVLRDQLLNIL
VAGRDTTAGLLSFVFYELSRNPEVFAKLREEVENRFGLGEEARVEEISFESLKSCEYL
KAVINETLRLYPSVPHNFRVATRNTTLPRGGGEDGYSPIVVKKGQVVMYTVIATHRDP
SIYGADADVFRPERWFEPETRKLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEF
AHLSMDPDTEYPPKLQNTLTLSLFDGADVRMY
>CYP52A16 Candida tropicalis
AY230502
MSSSPSFAQEVLATTSPYIEYFLDNYTRWYYFIPLVLLSLNFIS
LLHTKYLERRFHAKPLGNVVLDPTFGIATPLILIYLKSKGTVMKFAWSFWNNKYIVKD
PKYKTTGLRIVGLPLIETIDPENIKAVLATQFNDFSLGTRHDFLYSLLGDGIFTLDGA
GWKHSRTMLRPQFAREQVSHVKLLEPHVQVFFKHVRKHRGQTFDIQELFFRLTVDSAT
EFLFGESAESLRDDSVGLTPTTKDFEGRGDFADAFNYSQTYQAYRFLLQQMYWILNGA
EFRKSIAIVHKFADHYVQKALELTDDDLQKQDGYVFLYELAKQTRDPKVLRDQLLNIL
VAGRDTTAGLLSFVFYELSRNPEVFAKLREEVENRFGLGEEARVEEISFESLKSCEYL
KAVINEALRLYPSVPHNFRVATRNTTLPRGGGKDGCSPIVVKKGQVVMYTVIGTHRDP
SIYGADADVFRPERWFEPETRKLGWAYVPFNGGPRICLGQQFALTEASYVTVRLLQEF
GNLSSDPNAEYPPKLQNTLTLSLFDGADVRMF
>CYP52A17 Candida tropicalis
AY230504
MIEQLLEYWYVVVPVLYIIKQLLAYTKTRVLMKKLGAAPVTNKL
YDNAFGIVNGWKALQFKKEGRAQEYNDYKFDHSKNPSVGTYVSILFGTRIVVTKDPEN
IKAILATQFGDFSLGKRHTLFKPLLGDGIFTLDGEGWKHSRAMLRPQFAREQVAHVTS
LEPHFQLLKKHILKHKGEYFDIQELFFRFTVDSATEFLFGESVHSLKDESIGINQDDI
DFAGRKDFAESFNKAQEYLAIRTLVQTFYWLVNNKEFRDCTKSVHKFTNYYVQKALDA
SPEELEKQSGYVFLYELVKQTRDPNVLRDQSLNILLAGRDTTAGLLSFAVFELARHPE
IWAKLREEIEQQFGLGEDSRVEEITFESLKRCEYLKAFLNETLRIYPSVPRNFRIATK
NTTLPRGGGSDGTSPILIQKGEAVSYGINSTHLDPVYYGPDAAEFRPERWFEPSTKKL
GWAYLPFNGGPRICLGQQFALTEAGYVLVRLVQEFSHVRSDPDEVYPPKRLTNLTMCL
QDGAIVKFD
>CYP52A18 Candida tropicalis
AY230505
MIEQILEYWYIVVPVLYIIKQLIAYSKTRVLMKQLGAAPITNQL
YDNVFGIVNGWKALQFKKEGRAQEYNDHKFDSSKNPSVGTYVSILFGTKIVVTKDPEN
IKAILATQFGDFSLGKRHALFKPLLGDGIFTLDGEGWKHSRSMLRPQFAREQVAHVTS
LEPHFQLLKKHILKHKGEYFDIQELFFRFTVDSATEFLFGESVHSLKDETIGINQDDI
DFAGRKDFAESFNKAQEYLSIRILVQTFYWLINNKEFRDCTKSVHKFTNYYVQKALDA
TPEELEKQGGYVFLYELVKQTRDPKVLRDQSLNILLAGRDTTAGLLSFAVFELARNPH
IWAKLREEIEQQFGLGEDSRVEEITFESLKRCEYLKAFLNETLRVYPSVPRNFRIATK
NTTLPRGGGPDGTQPILIQKGEGVSYGINSTHLDPVYYGPDAAEFRPERWFEPSTRKL
GWAYLPFNGGPRICLGQQFALTEAGYVLVRLVQEFSHIRSDPDEVYPPKRLTNLTMCL
QDGAIVKFD
>CYP52A19 Candida tropicalis
AY230506
MLDQILHYWYIVLPLLAIINQIVAHVRTNYLMKKLGAKPFTHVQ
RDGWLGFKFGREFLKAKSAGRSVDLIISRFHDNEDTFSSYAFGNHVVFTRDPENIKAL
LATQFGDFSLGSRVKFFKPLLGYGIFTLDAEGWKHSRAMLRPQFAREQVAHVTSLEPH
FQLLKKHILKHKGEYFDIQELFFRFTVDSATEFLFGESVHSLKDEEIGYDTKDMSEER
RRFADAFNKSQVYVATRVALQNLYWLVNNKEFKECNDIVHKFTNYYVQKALDATPEEL
EKQGGYVFLYELVKQTRDPKVLRDQSLNILLAGRDTTAGLLSFAVFELARNPHIWAKL
REEIEQQFGLGEDSRVEEITFESLKRCEYLKAVLNETLRLHPSVPRNARFAIKDTTLP
RGGGPNGKDPILIRKDEVVQYSISATQTNPAYYGADAADFRPERWFEPSTRNLGWAFL
PFNGGPRICLGQQFALTEAGYVLVRLVQEFPNLSQDPETKYPPPRLAHLTMCLFDGAH
VKMS
>CYP52A20 Candida tropicalis
AY230507
MLDQIFHYWYIVLPLLVIIKQIVAHARTNYLMKKLGAKPFTHVQ
LDGWFGFKFGREFLKAKSAGRQVDLIISRFHDNEDTFSSYAFGNHVVFTRDPENIKAL
LATQFGDFSLGSRVKFFKPLLGYGIFTLDGEGWKHSRAMLRPQFAREQVAHVTSLEPH
FQLLKKHILKHKGEYFDIQELFFRFTVDSATEFLFGESVHSLRDEEIGYDTKDMAEER
RKFADAFNKSQVYLSTRVALQTLYWLVNNKEFKECNDIVHKFTNYYVQKALDATPEEL
EKQGGYVFLYELAKQTKDPNVLRDQSLNILLAGRDTTAGLLSFAVFELARNPHIWAKL
REEIESHFGSGEDSRVEEITFESLKRCEYLKAVLNETLRLHPSVPRNARFAIKDTTLP
RGGGPNGKDPILIRKNEVVQYSISATQTNPAYYGADAADFRPERWFEPSTRNLGWAYL
PFNGGPRICLGQQFALTEAGYVLVRLVQEFPSLSQDPETEYPPPRLAHLTMCLFDGAY
VKMQ
>CYP52A21 Candida albicans SC5314
putative P450 drug resistance protein
XM_705082, orf19_10
MLEEISFESWYLYLIICGVLYFCTNYLYIQYLNKKLGAKSPGSC
KSDGCFGFRSGFEMLKAKKIGRQVDLLHERFNDLSNPEVNDTFTSYNFGFPMIITKDP
ENIKALLATQFNDFSLGRRYDFFKPLLGKGIFTLDGEGWKHSRSMLRPQFAREQIAHV
KALEPHFQLLKKHITKNKGQFFDIQELFFRFTVDSATEFLFGESVSSLKDESIGYNQD
EFDFAGRKDFPEAFNKSQIYLSTRSLLQNLYWLVNPKDFQNCNAIVHKFSDYYVNKAL
NATPEELEKNSGYVFLYELVKQTRDPQVLRDQALNILLAGRDTTAGLLSFAVFELARN
PQVWKKLREEIIERYADGATEISFETLKQCEYLKAVINETLRLYPSVPRNGRFANKNT
TLPRGGGPDGMSPILIKQGQAVMYSIYSTQRDPKYYGKDADVFRPERWFEPETRKLGW
AFLPFNGGPRICLGQQFALTEASYVLVRLAQCCENLQLTEGIEYPPAKLTHLTMCMFD
GVPIKVD
>CYP52A22 Candida albicans SC5314
79% to CYP52A4 orf19_7512
MSPSLVHQILAITHPYVEYLEENITKWYILVPGILIVLNVLTTLHTKYLEYKFNAKPVTNFIQDYTFGVITPLILIYYKS
QGTVMEFANNFWNFKFLIKNPDVGTGELRIFGMHLIETKDPENIKAVLATQFNDFSLGTRHGFLYSLLGDGIFTLDGAGW
KHSRSMLRPQFAREQIAHVKILEPHMQVFFKHIRKNKGKTFDIQELFFRLTVDSSTEFLFGSSVESLRDETIGMSPSVKN
LAGRDEFADAFNYSQTINAYRFLLQQFYWLCNGTKFRKSIAAVHKFSDFYVQKALSLSQDELDEQKGYVFLYELAKQTRD
PKVLRDQLLNILVAGRDTTAGLLSFVFFELARNPEVYAKLKEEIYNKFGSGEDARIDEITFESLKQCEYLKAVINESLRL
YPSVPHNFRTATRNTTLPRGGGPDGMSPIVVKKGQSVMYTVLVTHRDTKTYGADANEFRPERWFEPETRKLGWAYVPFNG
GPRICLGQQFALTEASYVTVRLLQEFEHLTMDAETRYPPKLMNSLTLSLLDGANVEMY
>CYP52A23 Candida albicans SC5314
78% to CYP52A5 orf19_7513
MSVSDIVQEYITKWYVVIPTLFVVYQVVDFFYVRSLRSRLGAKAPTNNESDGYWGFHLPFLLVSKKAEGTIIDFAGERFK
SIAHPEVPTFQFPIFTVKVISTVDPENIKAVLATQFNDFSLGTRHNQFAPLLGDGIFTLDGAGWKHSRSMLRPQFAREQV
AHVKALEPHMQVLFKHIRKSGGRTFDLQELFFRFTVDSATEFLFGESVESLRDESIGMALEAVDFDGKKEFAEAFNFSQN
YLASRAVMQQMYWLLNSSEFKSCNSKVHKFAEYYVNKALELSHEELEKQQGYVFLYELAKQTRDTKVLRDQLLNILVAGR
DTTAGLLSFVFFELARNPRVFAKLREEVEEKFGVGEDARVEEISFESLKSCEYLKAVLNECLRLYPSVPQNFRVATKNTT
LPRGGGSDGMSPILVRKGQTVMYSVYVTHRDTKVYGKDADEFRPERWFEPETRKLGWSFVPFNGGPRICLGQQFALTEAS
YVTVRLLQEFGHLTMDPNTDYPPKKMSHLTMSLYDGTNVEMY
>CYP52A24 Candida albicans SC5314
78% to CYP52A3 orf19_5728 partial sequence
MSSTTFNDIIDSVLPYLTKWYTILIGAGLIFVLSTNLKNAYYSYKLGCKNPVHLKRAGWTGIPALIDAIKAKNSGKLAEF
GGDTFDELNSKNFYLNVAGVLKIIFTIEPENIKAVLATQFNDFSLGTRHAHFYPLLGDGIFTLDGEGWKHSRAMLRPQFA
REQIAHVKSLEPHIQILAKQIKLNKGETFDLQELFFRFTVDTATEFLFGESVHSLYDDKLGIPPPNDIPGRDNFATAFNT
SQHYLATRSYSQTFYWLTNNKEFRDCNAKVHHLAKYFVDKALNSTEKEIEEKSQGGYVFLYELVKQTKNPKVLQDQLLNI
MVAGRDTTAGLLSFAMFELARNPKVWNKLREELEANYGVGEEARVEDITFENLKKM
>CYP52A25 Candida dublinensis
79% to CYP52A3 Candida maltosa
cdub_593-g99.1
MSSATTSSNIIDSVLPYLTKWYTILIGAGLIFILSTNLKNAYYSYKLGCKNPVYLKRAGWTGIPALIDAIKAKNSGKLAE
FGDDTFEELNTKTFYLNVAGVLKIIFTIDPENIKAVLATQFNDFSLGTRHAHFYPLLGDGIFTLDGEGWKHSRAMLRPQF
AREQIAHVKSLEPHIQILAKQIKLNKGETFDLQELFFRFTVDTATEFLFGESVHSLYDDKLGIPPPNDIPGRDNFATAFN
ISQHYLATRSYSQTFYWLTNNKEFRDCNAKVHYLAKYFVDKALNSTEEEIEEKSQGGYVFLYELVKQTKNPKVLQDQLLN
IMVAGRDTTAGLLSFAMFELARNPKVWNKLREEIETNFGVGEESRVEDITFENLKKCEYLKAILNETLRLYPSVPINFRT
STKDTTLPTGGGRDGTSPIFVPKGSTVAYTVYKTHRLEEYYGKDSYEFRPERWFEPLTKKLGWAYLPFNGGPRICLGQQF
ALTEASYVITRLAQLFPVLETREKQYPPNKCIHLTMNHDEGVFVSMN
>CYP52A26 Candida dublinensis
89% to CYP52A21 Candida albicans
cdub_14-g136.1
MLEEISFESWYIYLFICGVLYFGSKYFYTQYLNNKFGAKLPGSFRSDGLFGFKNGFEMLKAKKVGRQVDLVHSRFNDLSK
THVNDTFKEYNFGIPVIVTKDPENIKALLATQFNDFSLGRRSDFFYPLLGKGIFTLDGEGWKHSRAMLRPQFAREQIAHV
KALEPHFQLLKKHITKNKGKGFDIQELFFRFTVDSATEFLFGESVSSLKDESIGYNQDEFDFDGRKDFPEAFNKAQIYLA
TRAILKDLYWLVNPKDFQNCNAIVHKFSDYYVNKALNATPEELEKNSGYVFLYELVKQTRDPQVLRDQALNILLAGRDTT
AGLLSFAMFELARNPQIWQKLREEVIEKYADEVTEIAFETLKQCEYLKAVINETLRLYPSVPRNGRFANKNTTLPRGGGP
DGMSPILIKQGQGVLYSIYSTQRDTKFYGKDADVFRPERWFEPETRKLGWAFLPFNGGPRICLGQQFALTEASYVLVRLA
QSYENLQLTENIEYPPPKLTHLTMCMFDGVPIKIA
>CYP52A27 Candida dublinensis
94% to CYP52A23 Candida albicans
cdub_14-g720.1
MTVSTLEIQDIIQQYITKWYVIIPTLFVVYQVVDFLYVRSLRSRFGAKAPTNNESDGYWGFHLPFLLVSKKAEGTIIDFA
GERFKNITHPEVPTFQFPIFTVKVISTVDPENIKAVLATQFNDFSLGTRHNQFAPLLGDGIFTLDGAGWKHSRSMLRPQF
AREQVAHVKALEPHMQVFFKHVRKSGGRTFDIQELFFRLTVDSATEFLFGESVESLRDESIGMALEAVDFDGKKEFAQAF
NFSQNYLASRAVMQQMYWLLNSSEFQSCNTKVHKFAEYYVNKALELSPESLEKQQGYVFLYELVKQTRDTKVLRDQLLNI
LVAGRDTTAGLLSFVFFELARNPRVFAKLREEIEQKFGVGEDSRVEEISFESLKLCEYLKAVLNECLRLYPSVPQNFRVA
TKNTTLPRGGGPDGLSPILVRQGQTVMYSVYVTHRDTKVYGKDANEFRPERWFEPETRKLGWSFVPFNGGPRICLGQQFA
LTEASYVTVRLLQEFGHLTMDPNTQYPPKKMSHLTMSLFDGTNVEMY
>CYP52A28 Candida dublinensis
93% to CYP52A22 Candida albicans
cdub_14-g719.1
MSPSLVHQILAIAHPYVEYLQANFTKWYILVPGILIALNVLTFLYTKYLEYKFNAKPVTNFIQDYTFGVLTPLILIYYKS
QGTVMEFANNLWGNRFFIKNADVGTGELRIFGMHLIETKDPENIKAILATQFNDFSLGTRHGFLYSLLGDGIFTLDGAGW
KHSRSMLRPQFAREQVSHVKILEPHMQVFFKHVRKNKGKAFDIQELFFRLTVDSSTEFLFGSSVESLRDETIGMSPSVKN
LAGRDEFAEAFNYSQTINAYRFLLQQFYWLCNGSKFRKSIATVHKFSDFYVQRALSLSKAELDDQKGYVFLYELAKQTRD
PKVLRDQLLNILVAGRDTTAGLLSFVFFELARNPTVYAKLKEEIYNKFGSGEDARIDEITFESLKQCEYLKAVINESLRL
YPSVPHNFRTATRNTTLPRGGGPDGMSPIVVKKGQSVMYTVLATHRDTKTYGADANDFRPERWFEPETRKLGWAYVPFNG
GPRICLGQQFALTEASYVTVRLLQEFGHLTMDPETCYPPKLMNSLTLSLLEGANVEMY
>CYP52A29 Candida lusitaniae
55% to CYP52A13 Candida tropicalis
CLUG_03984.1
MSLHGVFGGMSIWSSVLLFIGIYLAGSYIRRYIAYKRSGAMWPAYGTDKCLGFKVVREMLKMRQIGRAPDFFQSKFEITG
VYTGGLLVGGRYAITTRDPENVKAILATQFNDFNLGNRNQHIKVTLGDGIFTLDGAGWKSSRAMLRPQFAREQIAHVQSL
ERHVQRLAQKVRGTKGERFDIQPLFAKLTIDSGTEFLFGESCESLVDGESESETGLDPALKAVFAEAFNYTQTILFQRLS
LQKLYFLVDGFKFRRQNRIVHQVTDFFVERALHASDKEAHSSSRGGYVFLYELMKQTRDPKVLRDQCLNVLLAARDTTSG
LLSFCFFELARNPAVFARLREEISFHFGLGESADLSAISFESLKKCEYLRAVLHETLRMYPSVPANFRVATRDTTLPHGG
GPDESKPIFVPKGTMCIYQVYSVHRSEVHYGKDYNDFRPERWFEERTKKLGWAFLPFNGGPRICLGQQFALTEASYVIVR
LLQMFEHIESFDSVYPPAKATHLTMSLFDGANIALW
>CYP52A30 Candida lusitaniae
55% to CYP52A23 Candida albicans
CLUG_04851.1
MLLSELKTAWDSFSSHLSDNVFLYYAELLILTLVVYHTYRTSKKWYLRKKLGAESAKWLQTSSAGWINSLPMREILDAKR
EGYLLRELWKYWHDDDENFMVKVAGTEMFVTTDPENYKALLATQFNDFKLGIRHSHFKPLLGDGIFTLDYGGWKHSRALL
RPNFSREKVGHLHSLETHLQVLFKHIRKHNGKPFDLQELFFRLTVDTATEFLFGHSANTLEDESIGIHKEETFEGEKEFY
DCFNISQAICATRAWTQKGYFLTIPFLYKEFTRCNRVVHNFADYYVNMALNMSQDELEKESNDGYIFLYELAKETRDPKV
LRDQLLNIMIAGRDTTAGLMSFIFFELAKRPDVWAKLKAEIYERFGYGDNVRFDEITFETLKKCTYLKNVVNETLRLYPS
VPVNYRQANINTTLPRGGGPDGDKPVLIEKGNAVGYIVSATHRNEKYYGKDAAEFKPERWDDKNLKPGWAYLPFNGGPRI
CLGQQFAITEASYVVTRMIQEFPNIADHDVEPDTYPPRMISQLTNSLAAGCYVSLTK
>CYP52A31 Candida lusitaniae
52% to CYP52A18 Candida tropicalis
CLUG_04098.1
MSLFRELDPVQLVYVVISLFFASFVYNELKGIYLSRKWHTKSPVKTYRGLFSLPQLVRSRKAVDSGHFVDYFRDQYIKYG
ADTLDFTGFGSKIFFTKNPHNVKSLFATNFDDWSIGARKRAFKPFLGVGVFVTDGEVWKHSRTMLKPQFSREQIAHVHSV
ESHYKLFAQHIRSYRGQEFDIQPLFMKLTMDASSEFLFGESIHLLHDDSIEHEKDTSDIKGKKELAEDLSFLQTYLMFRV
MLLDWFWLENSKKFSEAIKRVHAFTSQFVDRVLSLTPEEREANSKDGYTFLYELAKVTNDPIVMRDQILNVMLAGRSTTA
SLLCSVLLELSRNPEVYEKLKNEVYEQFGNGKTKGEEITFETLKKCTYLRWVLNEGLRMYPPVPSNLRQAVRDTTLPKGG
GPDGESPVLVRKGQYVALHIYSMHRSEEFYGKDALSFRPERWADLSKIGWAFMPFGSGPRICLGQQFALTEASYILVRMV
QDFPHIASHNKTYPPRTYSRSTMHYIDGIRISLY
>CYP52A32 Candida parapsilosis
71% to CYP52A5 Candida maltosa
CPAG_03577
MSDLTLFDYATKWYVLAPALIVLYAVYIQVYNAYLIKKLGAAKEANCEGDGLFGFRLPFWLIERKENGTVVDYVAERFDE
VSHPSIPTFSIRIFMVKLWMTKDPENIKALLATQFNDFCLGTRHAQFKPLLGDGIFTLDGQGWKESRQMLRPQFARDQIS
HVKMLEPHIQVLFKQIHKNKGQVFDLQELFFRFTVDSATEFLFGESVDSLKDASIGMQAVSNEVEGKEQFAKSFNFSQNY
LASRTTMQGLYWLLNSKKFRDNNAVVHKFAQYYVKRALSLTPEELEKQNGYVFLYELAKHTRDPKVLQDQLLNILVAGRD
TTAGLLSFVFFELARSPAVLTKLREEIGAKFGLDKEARVDEITFESLKNCEYLKAVLNECLRLYPSVPQNFRVATKNTTL
PRGGGPDGMSPIFVTKGQIVQYCVYATHRMEEFYGKNANEFRPERWFEPQTRKLGWAFVPFNGGPRICLGQQFALTEASY
VTTRLVQEFSSLWMDPNTQYPPHKMSHLTMSLYDGCNVKME
>CYP52A33 Candida parapsilosis
73% to CYP52A5 Candida maltosa
CPAG_04394
MSDFDIMEYSTKWYIIAPALIVFYVVYKKINEAYLMKKLGAVRETNPEGDGYLGFKLPFWLIERKKNGTLVDFSEQRFHE
ISHPEVPTLSMRIFTVKLWATKDPENIKALLATQFNDFSLGTRHPQFKPLLGDGIFTLDNQGWKDSRQMLRPQFAREQIS
HVKMLEPHIQVLFKHVRKNKGQVFDLQELFFRFTVDSATEFLFGESVDSLKDASVGMQADSNEIDGKEQFAESFNFSQNY
LASRAVMQGLYWLLNSKKFRDSNAVVHRFAQHYVKRALSLSPEELEKQNGYVFLYELAKHTRDPKVLQDQLLNILVAGRD
TTAGLLSFVFFELARNPAVLAKLREEIGTKFGLGKEARIEEITFESLKNCEYLKAVLNECLRLYPSVPQNFRVATRNTTL
PRGGGPDGMSPILITKGQTVNYSVYATHRSEEYYGKDANEFRPERWFEPQTRKLGWAFVPFNGGPRICLGQQFALTEASY
VTTRLVQEFSSLWMDPNTQYPPHKMSHLTMSLYDGCNVKME
>CYP52A34 Candida parapsilosis
71% to CYP52A5 Candida maltosa
CPAG_04395
MRGQCGLPFFFRKNTCNSTITLESCNGYLTRATLATDIKRWAILFSCSTSIQTCLFFNYYNEVSMLDFNIMGYTISLFVL
APALIVLYVVYKIITEVYLMKKLGASRETNVVSDGAFSLKLAFTLIASKNNGTLIDYVAEMYRGAPHPEVPTFSSRIFTV
KFYLTKDPENIKALLATQFNDFCLGTRHAQFQALLGDGIFTLDGKGWKDSRQMLRPQFAREQISHVKMLEPHIQVLFKHV
RKNKGQVFDLQELFFRFTVDSATEFLFGESVDSLKDASVGMQADSNEFDGKEQFPQSFNFSQSYLASRVVISFMYWVLNS
KQFRDSNAVVHRFAQHYVKRALSLSPEELEKQNGYVFLYELAKHTRDPKVLQDQLLNILVAGRDTTAGLLSFVFFELARN
PAVLAKLREEIGTKFGLGKEARIEEITFESLKNCEYLKAVLNECLRLYPSVPQNFRVATRNTTLPRGGGPDGMSPILVTK
NQEVHYSVYSTHRMEEYYGKDANEFRPERWFEPQTRKLGWAFVPFNGGPRICLGQQFALTEASYVTTRLVQEFSSLWMDP
NTQYPPHKMSHLTMSLYDGCNVKME
>CYP52A35 Candida parapsilosis
65% to CYP52A21
Candida albicans
CPAG_05481
MIDSAIATYWYITIPSVFLLYIIISYINEQYLMRKFKAKPFTNYISGGFFGFQEGIAALKHKKAGTAIERYRDLYEELPN
PDVPTYKSFVFGTPLVFTKDPENIKAILATQFNDFSLGIRHAHFDPLLGDGIFTLDHQGWKDSRAMLRPQFARDQIAHVK
ALEPHFQFLLRHIEKNNGQFFDIQELFFRFTVDSATEFLFGSSVSSLQDESIGCDTTELDFVGRKEFPEAFNKSQLILST
RALLQKMYWIYNPKEFKKCNAIVHQFSDYYINKVLSCTPEEIEKQSGYVFLYELVKQTRNPKVLRDQALNILVAGRDTTA
GLLSFVLFELARNPDIYKKLRDEILDKFGTSNLEEITFESLKKCEYLKAVLNEALRMYPSVPRNYRVSTRNTTLPRGGGS
DGTSPIFIPKGRSVIYNIAATHMDPRYYGKDVEEFRPERWFEESTKKLGWAYLPFNGGPRICLGQQFALTEASYVVARLA
QTISKLELKDGYTYPPKKMTHLTMCMFDGVYVKMEKDATAAAAKSG
>CYP52A36 Candida parapsilosis
65% to CYP52A21 Candida albicans
CPAG_05482
MIETVSIANIVAYWYITIPAVLLGHFVIGYIHEQVLIRKLGAKPFANNVNGGFFGSALGVKSIVAKGKGRAVEFYQNLYH
VSPHTEVPTIKTYIFGTPIVFTKDPENIKAILATQFQDFCLGNRYHFLKPLLGKGIFTLDHEGWKDSRAILRPQFARDQI
AHVKALEPHFQFLLRHIEKNNGQFFDIQELFFRFTVDSATEFLFGSSVSSLQDESIGCDTSALDFSGRLEFAEAFNVSQV
YLSTRALLQRIYWLCNNQEFKKCNKIVHQFSDYYINKVLNCTPEEIEKQSGYVFLYELVKQTRDPIVLRDQALNILLTGR
DTTAGLLSFVLFELARNPEMYAKLRHEILDKFGTSNLEDITFENLKKCEYLKAILNETLRMYPSVPRNARVATRNTTLPR
GGGSDGTSPVFIPKGKAVIYNIAATHMDPRYYGKDVEEFRPERWFEESTKKLGWAYLPFNGGPRICLGQQFALTEASYVV
ARLAQTISKLELKEGYEYPPKKMTHLTMSMFDGVYVKMEL
>CYP52A37 Candida parapsilosis
58% to CYP52A12 Candida tropicalis
CPAG_05523
MALDLASISSFITIHLFTWYGAIISFALIYATVGKIKREIFIRKHGCKEAYVFPDGGPLGLVLAFILQKYKSDGTILDFA
LSLYEDYGKRTTFTAYLFGVRVVVSGEPENMKAVLATQFNDYSLGSRHAHFAPLLGDGIFTLDNEGWKESRQLLRPQFAR
EQISHVKMLEPHVQVLAEHIRKHKGQTFDIQELFFRLTVDASTEFLFGESVHSLYDESIGRKCDPEVAGFADAFNAAQVA
LGVRTYLQVMYFLYNPPSFWKNTRTVHNFARKFVDKALSLTPEQVEERTQKHGYTFLYELVKHTRDPKVLQDQLLNIMVA
GRDTTAGLLSFTIFELARHPKVWNRLKDEIYHHFGSGEDSDVENISFETLKQCTYLKWVLNEILRLYPSVPVNFRVANKD
TTLPVGGGPDGTSPVFIGKGTTFAYSPYMTHRLEKFYGKDSFEFVPERWENSPKLGWAYLPFNGGPRICLGQQFALTEAS
YVIVRLAQMFPNLSSSYNGPEPCRKLVHLTMSLMDGAEIQMS
>CYP52A38 Candida parapsilosis
74% to CYP52A25 Candida dublinensis
CPAG_02285
MSSILDQASDFGEKLLPYLTKWYSIVFIILLTYIPLLNIRNAYVGWKLGCQDPPKFRKAGFTGVFALIEAVKKKNQGRLV
DWGDEQFDEYPNHSMYLNVTGLLKIVLTVDPENIKAVLATQFNDFSLGTRHAHFAPLLGDGIFTLDGNGWKDSRAMLRPQ
FAREQIAHVKSLEPHLQILAKHIKSTNFQTFDLQELFFKFTVDTATEFLFGESVHSLYDDKLGIAPPNDIPGREHFADAF
NKSQKYLATRTYLQMFYFLINPKEFRDCNKKVQHLAQYFVNKALNFTPEELEEKSKDGYIFLYELVKQTKNPQVLQDQLL
NIMVAGRDTTAGLLSFTMYELARNPQVWQKLRQEIVENFGDGEDARVESITFETLKKCEYLKAVLNETLRLYPSVPVNFR
TATRDTTLPRGGGADGTKPIFVPKGSTVAYTVYKTHRLEEYYGKDSKEFKPERWENIKRLGWAYLPFNGGPRICLGQQFA
LTEASYVVARLVQMFPTLESQDDTYPPKKCVHLTMNLDEGVFVKMK
>CYP52A39 Candida guilliermondii
66% to CYP52A14 Candida tropicalis
PGUG_01238.1
MFDVDTVHNFFTSWYGILLAVLIGYHVFDYIRIQIVMKKLGCVSPPVESDGFFGFKLLYTSLKHKKEGTLVNFIKERFET
VGKDTFSFRIAGTPVISTKNPENIKALLATQFSDFALGTRHAQFKPLLGDGIFTLDGSGWKHSRAMLRPQFAREQVAHVK
SLEPHIQMLAKHVRRAKGGAFDVQSLFFRLTVDSATEFLFGESVESLQDESIGMAKDAVDFDGKAGFAEAFNTAQVYLSI
RSLAQKAYFLVNNKEFRSSNEKVHKFADYYVQKALNSSPEELEKHSQDGYIFLYELVKQTRDPHVLRDQLLNILLAGRDT
TAGLLSFTFYELARNPQVWSKLKEEIYEKFGKGDDARLEDITFESLKKCEYLKALLNEVLRLYPSVPQNFRVAQKDTSLP
RGGGPNRDQPIFIAKGQTVTYTVYAMHRDEQFYGKDSEVFRPERWFEPETRKLGWAFLPFNGGPRICLGQQFALTEASYV
IARLAQLFPNLASHDDEYPPRKASHLTMCHQSEVKISLA
>CYP52A40 Candida guilliermondii
60% to CYP52A25 Candida dublinensis
PGUG_05855.1
MSELLDSIQPYLTKWYVVISALLVSFFIAHKISVARFKATHNCAASPEYYKVNWFSLPLLYRLIQVKREGRLLDFAQKIY
DDVKALTFVIKIVGVPVIITRDPENMKAVLATQFNDFALGTRHAHFKPLLGDGIFTLDGNGWKQSRSMLRPQFSREQVAH
VQALEPHLQRLAKHIRLADGETINIQDLFFKLTVDTATEFLFGQSVYSLKDAAINDPPTEDFDGRSSFANSFNTAQTYLG
TRAYLQMFYFIVNNSDFRKCCNQVHDFTRFYVQKGLDMTPEELEKKSENGYVFLYELVKQTRDPKVLQDQLLNILLAGRD
TTAGLLSFTFFELARHPRVFNKLKEEIYEAFGKGDDARVSEITFESLKKCEYLKWVMNEMLRLYPSVPVNFRVATKRTTL
PRGGGPDGNSPIYVGKGTTVAYSVYSTHRMEEYYGKDADEFKPERWAESRKLGWAYVPFNGGPRICLGQQFALTEASYIV
TRLLQMFDKLELHDDRPYPPAKSVHLTMCHQDGVYVSLS
>CYP52A41 Candida guilliermondii
52% to CYP52A12 Candida tropicalis
PGUG_04005.1
MLSATYVILTLVAFFTVRQVIITIKRRKFAREHGCQNFTKTVGMVSVIDNIKKVYKARREGRLTEQLQESYDLYGVDTFQ
ARAIGTSAVFTRHPENIKAMIATQFDDFDIGKRQQVFRPLLGFGIFAAEGQRWKHSRAMLRPQFAREQVAHVQSLEVHLQ
NFVKLIKEQNGSFFDIQHLFHRLTMDASTEFLFGESVGSLKSPNNEFEAAFNTSQHYLTMRATLRGAYFLVNPKEFRDAN
EVIFKTVRYYVNKALNTSPQELAKQTEEGYTFLYQLVNQTRDPQVLQDEMLSIMLAGRNTTASLLSFLFLELSRNKHIWK
KLREEVHEHFGNGENARLEDITFESMKRCNYLKWVINETLRMYPSVPTNFRHAAKDTTLPRGGGPTGDSPVFIKKNTDVY
YTIYSTHRMKEYYGKDAEEFRPERWADLKNIGWAYMPFSSGPRICLGQQFALTEASYITIRLAQIFTELDTSDHAYPPLK
IANATMRPMNGVNVRFQ
>CYP52A42 Candida guilliermondii
62% to CYP52A23 Candida albicans
PGUG_05670.1
MNGFEEVHNFLTSWYGIVLAAIVAYNVFDYVRVKVVMKKLNCVGPTVESDGFFGFRVIFTLLKHKREGTLVDFRKDMELD
TLRFRVAGTPMVITRNPENIKAILATQFNDFVLGGRHDHLGPLLGDGIFTLDGSGWKHSRAMLRPQFAREQVAHVKSLEP
HIQLLAKHIRKFQGEPFDIQKLFFRLTMDSATEFLFGESVDSLHDETIGFSKSAIDFDGKNEFAEAFNTSQIYLSIRALA
QQVYFLINNKEFRDANAKVHKFADYYVQKALSFSTEELDKYSQDGYIFLYELAKQTRDPKVLRDQLLNILLAGRDTTAGL
LSFTFFELARNPDIWSKLKEEIYNRFGSGDDSNLEDITFESLKKCEYLKALLNEALRMYPSVPQNFRVAQKDTTLPTGGG
PNRDLPVFIRKGQTVAYMVYALQRDQRYYGKDSEVFRPERWFEPETRKLGWAFLPFNGGPRICLGQQFALTEASYVIARL
AQLFPNLASFDDEYPPRKASHLTMCHQNGVVISMT
>CYP52A43 Debaryomyces hansenii
54% to CYP52A3 Candida maltosa
CAG85755.1
MNWYIIIFIAYFVRRLIILCKNYWLARQWGCEPMQEFGGRFGIISLINVIKARREGFLVDYQKQTYIETDTDTIKSRLFH
KQLIHTKNAENVKAVVATQYDDFSIGKRHKFFKPLLGNGIFASEGERWQHSRTMLRPQFARERVAHVQALEPHLQVFAKH
VRKSEGGVFNIQILFHKLTIDAATEFLFGESVDSLRDASIGYESLPTDIDGKAGFDDAFNISQNYMMLRALAQDLYFLFD
SKEFREANRKIHKFTGHYVHKALETTQEELDAKSRDGYIFLYELVKQTRDPIILQDELLSIMLAGRNTTASLLSFLFFEL
ARNPEIWSKLKREVYEHFGNGDDVKLEKITFESMKKCTYLKWVINETLRMYPSVPQNFRVAKKDTTLPRGGGKDQQSPIF
VPKGQFVLYTTYSMHRLEAYYGKDADVYRPERWENLRNIGWAYMPFSSGPRVCLGQQFALTEASYITIRLAQMFPNLESH
DSKYPPPKLTNSTMRHLDGVFISLH
>CYP52A44 Debaryomyces hansenii
63% to CYP52A25
Candida dublinensis
CAG85832.1
MSTDKLKSYVEEISPYLTQWYVIALGGILVWYIGTSIKAYQFKQKYGCKEPPLVPGGFLSIKLLLDLLKTKSEGTMLEYA
EHFFSLVKSQTFKLKLATVPIIFTQDPENIKAVLATQFNDFALGTRHAHFKPLLGDGIFTLDGDGWKNSRLLLRPQFARE
QVAHVQTLEPHLQTLAEHISNKKGETFDIQELFFRLTVDAATEFLFGESVYSLRDGTVKDVAPLDFDGKSSFADSFNLSQ
SYLASRAYSQMFYFLINNKEFRNSNTKVHKFCKHYVEQALATSQDELDKKSKDGYIFLYELVKQTRNPKILQDQLLNILL
AGRDTTAGLLSFTFFELARNPDVFEKLKNEIYTHFGDGANPRIETITFESLKRCEYLKFVLNEVLRLYPSVPINFRVSTK
DTTIPRGGGPDKQDPVYVAKGTTVAYSVYTTHRLEQYYGKDSREFRPERWAENKKVGWAYVPFNGGPRICLGQQFALTEA
SYVVVRLIQMFPNLVSRDDRPYPPRKNVQLTMCHQDGVFISLNK
>CYP52A45 Debaryomyces hansenii
62% to CYP52A14
Candida tropicalis
CAG88380.1
MSSDTFHEFGVLFDRIQPYLTSLWAICIGAYILFSISTRINDRILMKKLGAKPMQMNAPNSFWGIPLMFRLLKAKREGTM
VDVTKERYKELGVDTFNVNIAGTHAVVTRDPENIKAILATQFNDFALGKRHTHFKPLLGDGIFTLDGAGWKHSRTMLRPQ
FAREKVAHVKALEPHLQTLAKHIINSKGERFDIQPLFFRLTIDSATEFLFGESVENLHDESVGLTRDPVDFDGKSGFADA
FNTSQTWLASRAVTQNLYFLVDGRSFRSSNAKVHKFADYYVRKALEASSEDLEKASRDGYIFLYELVKQTRDPVILRDQL
LNILLAGRDTTAGLLSFTFFELARNQDVYDKLKEEIYEKFGEGEDSRVDEITFESLKKCEFLKCVLNEILRMYPSVPQNF
RFAIRNTTLPKGGGPDGKSPIFVSKGKNLFYSMYSAHRNPKYYGKDAEEFRPSRWLEPEIRKVGWAFLPFNGGPRICLGQ
QFALTGASYIVVRLIQMFPNLSSFCEEYPPRKNTQLTMSHQNGVYIGMF
>CYP52A46 Debaryomyces hansenii
63% to CYP52A14
Candida tropicalis
CAG88381.1
MSSSAHELFRSIEPYLTNWWIICIGTYVLFSILTWINERILMKKLGAKPIQFIAPDPFWGIPLMFRLLRKKKDGTMVDMT
KERFEEFGIETFSFRVGGTPVITTKDPENIKAMLATQFNDFALGKRHTYFKPLLGDGIFTLDGAGWKHSRAMLRPQFSRE
QVAHVRALEPHLQTLAKHIINSKGERFDIQPLFFRLTIDSATEFLFGESVENLHDESVGLTRDPVDFDGKSGFADAFNTS
QAWLASRAVSKNLSLFVDGKEFRNSNAKVHKFADYYVRKALEASPEDLEKASRDGYIFLYELVKQTRDPVILRDQLLNIL
LAGRDTTAGLLSFTFFELARNQDVYDKLKEEIYEKFGEGEDSRVNEITFESLKKCEFLKCVLNEILRLYPSVPLNTRCAT
KNTTLPRGGGPDGQSSIFIPKGKSVLYSVYATHRNPKYYGKGAEEFRPSRWLEPEIRKVGWAFLPFNGGPRICLGQQFAL
TEASYIIVRLIQMFPNLNSFCEKYPPRKSSHLTMCHQDGVSIGMF
>CYP52A47 Debaryomyces hansenii
65% to CYP52A14 Candida tropicalis
CAG88382.1
MSSNFHEVVESIEPYVTNWWFICIGAYVLFSILTWINKRILMKRLSAKPMQVTARDAFVGIPLVFNLLKAKREGTMVDMT
KERYEEFGVDTFDFRIAGTHAIATRDPENIKAVLATQFNDFVLGKRHAHFKPLLGDGIFTLDGAGWKHSRAMLRPQFARE
QVAHVKALEPHLQTLAKHIINSKGERFDIQPLFFRLTIDSATEFLFGESVESLHDESVGLTRDPVDFDGKSGFADAFNNS
QAWLASRAVSQNFYFLLNGKDFKDSNANVHKFADYYVNKALETSPEDLEKASRDGYIFLYELVKQTRDPVILRDQLLNIL
LAGRDTTAGLLSFTFFELARNQDVYDKLKEEIYKKFGEGEDSRVDEITFESLKKCEFLKCVLNEILRMYPSVPQNFRFSI
KNTTLPRGGGPDGKSPILIPKGQNLLYSVYATHRNPKFYGKDADEFRPSRWLEPEIRKVGWAFLPFNGGPRICLGQQFAL
TEASYIIVRLIQMFPNLGSFCEEYPPRKSSHLTMCHQDGVFIGMS
>CYP52A48 Lodderomyces elongisporus
73% to CYP52A38 Candida parapsilosis
LELG_04957
MSSTFVQQVASLGQEIVPYFTKWYTVLILLVVTYIAAFNIKDAYMTWKLGCKNPLYYKPAGYTGVYSLYEIIQRKNKGEL
AEFAQEAFDEYTTNTVYVKIGGLMKIMFTVDPENIKAVLATQFNDFSLGIRHAHFAPLLGDGIFTLDGDGWKDSRAMLRP
QFAREQIAHVKALEPHVLMLAKQIANTKYETFDLQELFFRFTVDTSTEFLFGESVHTLYDDKIGVAPPNDIPGREAFADA
FNFSQHYLATRTYSQVFHWLFNSKEFRENNAKVHHLAQYFVKKALNFTPEELEEKSQDGYTFLYELVKQTRNPKTLQDQL
LNIMVAGRDTTAGLLSFCMFELARNPEIWQRLRTEVLDNFGDGSTKEQIDSITFENLKKCEFLKSVLNETLRLYPSVPIN
FRTATRDTTLPHGGGSDGSKPIFVPKGSTVAYAIYKTHRLEEYYGKDSQEFKPDRWTDMKRLGWAYLPFNGGPRICLGQQ
FALTEASYVLARLAQLFPTLQSRDETYPPKKCIHLTMNHAEGVFVGMK
>CYP52A49 Lodderomyces elongisporus
72% to CYP52A37 Candida parapsilosis
LELG_03506
MAISLETLPLAIVQHLFTWYGAITLLITTYFTGLYIRREIFRRQRGCMEPFVYPEGGPLGIKLGYDLQDKKKKGEIVDFM
CKLYHKFDRVKTFSAYLFGVRVVVGVEPENLKAVLATQFNDFGLGTRHAHFKPLLGNGVFTLDGEGWKESRQMLRPQFAR
DQIAHVQALEPHIQILAKHIRASKGKSFDIQELFFRFTVDTSTEFLFGESVHSLYDASIGLECDPEVAGFAEAFNETQKD
LAVRTYLQVLYFLYNPPSFWKNTKVVHKFAKRFVNKALNLSKDELEEHCKHHYTFLYELAKHTRDPKVLQDQLLNIMVAG
RDTTAGLLSFTFFELARNPEVWQKLKDEIYQHFGSGEDADVSKITFETLKQCTYLKWVLNEILRLYPSVPINFRTALKDT
TLPTGGGPDGTAPVFIGKGTTFAYSVYLLHRIEEYYGKDANEFRPERWADLKQLGWAYLPFNGGPRICLGQQFALTEASY
TICRLAQMFPNLASNYDQPDPCKKLIHLTMSLMDGAWIEMS
>CYP52A50 Lodderomyces elongisporus
71% to CYP52A37 Candida parapsilosis
LELG_03505
MMETIISNTGHALQPPYSSHTIWFGILFIIFGTYFICIFIKREIFRRAHHCKEPIIFPEGGPLGLRLGYLLQRLKTTGEL
VDFPMVLYEKFGRRTTFSAYLFGVRVVASVNPDNLKAVLATQFNDFGLGTRHAHFKPLLGNGVFTLDGEGWKESRQMLRP
QFAREQVAHVQTIEPHLQTLAKHIKTHNGGTFDIQELFYKLTVDTSTEFLFGESVHSLYDASIGLECDPEVAGFAEAFNE
TQKALAVRTYLQVLYFLYNPPSFKRNTKIVHKFAKRFVNRALCLTPKELEEHCKHNYTFLYQLAKHTRDPQVLQDQLLNI
MVAGRDTTAGLLSFTIFELARHQNVWEKLKKEIYQHFGSGEDALVNKITFETLKQCTYLKWVLNEILRLYPSVPINFRVA
TKDTTLPTGGGLDEKSPVFIGKGTTFAYSPYLLHRMPMHYGEDATVFRPERWADLKQLGWAYLPFNGGPRICLGQQFALT
EASYTICRLAQMFPDLKSMDDSPDPCKKLIHLTMSHMDGVWIQMSE
>CYP52A51 Lodderomyces elongisporus
75% to CYP52A35 Candida parapsilosis
LELG_03309
MLLDEFITYLNHWYVIIPLAFTTYHVFHYIYLNQLAKKFGAKPITNVLSDGWFGFKNGTQAIALKNKGQAVEWAQEKYYE
TKHPEIPTFKERIFGLYLVFTKDPENIKAMLATQFSDFSLGHRLAYFDPLLGKGIFTLDHEGWKDSRAMLRPQFAREQIA
HVKSLEPHIQYLFKHIDKNQNIQSKNKIENADYETSISASYFDIQELFFRFTVDSATEFLFGGSVSSLQDETIGCDTRDI
DFAGRRQFADCFNKAQNYLATRNLLQKLYWLVNPKEFRECNKVVHEFTNYYVNKVLSYSPEELEKISDGYVFLYELAKQT
RDPNVLRDQSLNILLAGRDTTAGLLSFVIFEMAKNPQMWTKLRNEILERFGTTNLEDITFENLKKCEYLKAVLNETLRLY
PSVPRNARVATRNTTLPRGGGPDGLSPIFIAKGSTVGYNISACQRDETHYGKDVDEFRPERWFEESTRKLGWAYLPFNGG
PRICLGQQFALTEASYVITRIAQTYSKLELKPGYGYPPKRMTHLTMCLFDGCWVKMERAQV
>CYP52A52 Lodderomyces elongisporus
70% to CYP52A5
Candida maltosa
LELG_00044
MSDLLPPIIQEYATKWYILLPAIVLVYLTFSFLFEIYLKRKLGAKGFTNTERDGYFGFYTPFLLLRLKKEGNLVDFGTER
YQFLQNPDVPTFKLRMFGIPIVTTKDPENIKAILATQFSDFLLGLRHAQFMPLLGDGIFTLDGQGWKDSRQMLRPQFARE
QISHVKLLEPHMQVFFKHVRKHKGMTFDIQELFFKLTVDSATEFLFGNSVECLKDSSIGMRPNSADFEGKEQFADAFNYS
QTYLSTRVVFQKFYWLLNGKKFKECNKIVHSFAQYYVNKALQLTPDDLQKQENYVFLYELAKNTRDPQVLQDQLLNIMVA
GRDTTAGLLSFVFFELARNQDVLAKLKEEIYGKFGFGADARVDEITFESLKGCEYLKAVLNECLRLYPSVPNNFRTALRD
TTLPRGGGKDGMSPILIRKGQNVIYSVYALHREEKFYGKDAAEFRPERWFEPETRKLGWAFVPFNGGPRICLGQQFALTE
ASYVTTRLIQEFEHLTMDPDTEYPFKKMSHLTMSVYGGVNVQMY
>CYP52A53 Pichia stipitis
65% to CYP52A40 Candida guilliermondii
JGI model e_gww1.3.1.449.1
MSAELAFEYLTKWYSILIGAALIYGIARYIKIQLFIRKHGCEETPFLPDAKWFAIPIMSRVLKAKNEGRLVDLAQSFMTS
DRRTTHVYLGPARIIFTIDPENMKTMLATKFNDYALGFRHTHLAPLLGDGIFTLDGEGWKHSRSMLRPQFAREQVAHVRA
LEPHVQVLMKHIRLNKGKTFDLQELFFKLTLDTSTEFLFGESIYSLYDSSIGLTPPTDIQGRSEFADAFNTSQKYLGTRA
WLQFMYWVVQNREFYQCNAKVHKVAKYYVKRALNFTPDELEKASANGYTFLYELVKQTRDPVVLQDQLLNILVAGRDTTA
GLLSFTFFELARNPDVFEKLKNEIYEHFGKGDESRVEDITFESLKQCEYLKFVLNEALRMYPSVPLNFRVSTKDTVLPNG
GGKDGTKPVFVGKGTTVAYTVYCTHRDEKYYGKDANVFRPERWATLNKLGWAYLPFNGGPRICLGQQFALTEASYVIVRL
LQNFPNLVSKDDRPYPPAKSMHLTMCHQDGIFVELS
>CYP52A54 Pichia stipitis
63% to CYP52A44 Debaryomyces hansenii
JGI model e_gww1.3.1.459.1
MYEKTIIALLYLSKWYVLLGSAVAVLALYRYITVQLIIRKHGCKDPIKFTQGGFLCIPIILELLRRMKTGEMIDEGFRLF
NEYPDTTQYVNLFGVRVLLTGEPEVYKAVLATQFNNFALGFRHSHFAPLLGDGIFTLDGEGWKNSRAMLRPQFARQQVSH
VQMLEPHIQTLAKHIKARKGTTFDLQELFFRLTMDSATEFLFGESVRSLHDEVIGMQRPDIEGISNFSEAFNTSQRYLAV
RAYSQVLYWLTNPKEFRDCNAKVQKVAQYFVNKALSFSDSELEEKSKKGYIFLYELTKQTRDPKVLQDQLLNILIAGRDT
TAGLLSFTFYELARNPAIFEKLKAAIYADFGRGDVSEISFESLKKCEYLKFVLNEALRLYPSVPVNFRVATKDTVLPTGG
GPDGQSPMFVRKYTTVAYGVYFTHRMKQFYGEDAEVFKPERWAENRKLGWAYLPFNGGPRICLGQQFALTEASYVVVRLI
QMFPNIVSKDDGPYPPRKSVQLTMCLQDGVKIQMS
>CYP52A55 Pichia stipitis
63% to CYP52A14 Candida tropicalis
JGI model
fgenesh1_pm.C_chr_3.1000237
MANFIEFVTTNWYIIIPALLVLHKVFDLLYVQYLYRKLGAKPCTNQTDDHAFGIRAGFEMLKKKNEGTVVDFGAERFESR
IDPKIPTFSMRLFLIPIVLTRDPENIKALLATQFNEFVLGSRFEQLAPLLGKGIFTLDGEGWKHSRAMLRPQFAKEQVAH
VQSLEPHIQALAKHVRNAKGKLFDIQELFHRLTVDSATEFLFGQSVESLRDESVGMADEATDFAGKSTFAASFTIAQNWL
ANRAVAQKFYFLINPKEMRDSIKDVHRFVDYYVQVALDTPQDELDKKSKDGYIFLYELVKQTRDPYVLRSQLLNVLLAGR
DTTAGLLSFAFFELARRPDIWSKLKDEIYENFGLGENSKVDEITFESLKRCEYLKAFLNETLRLYPSVPVNFRVATKDTT
LPRGGGKDGSEPILVRKGQSVFYSVYATHRSEAYYGKDRHVFRPERWFEPSARKLGWAYLPFNGGPRICLGQQFALTEAS
YVVARLIQLFPNIENYEPEEVYPPFKNSQLTMNLLNGLHIGLY
>CYP52A56 Pichia stipitis
59% to CYP52A38 Candida parapsilosis
JGI model
fgenesh1_pm.C_chr_8.1000042
MFMTTDPENFKAMLATQFNDFSIGRRYQILSPVIGDSIFTLDGEGWKHSRAMLRPQFVREQVGHVQALEPHLQLLAKHIR
SYKGETVDLQQLFTKFTLDTATEFLFGQSVHTLYDERIGMKTPDDVPYAKDFTDGLFITQKYTSERGYAQQFYWLIDGKE
FRTAIANVHKFARFYVDRALNFSQAELEKKSQESYTFLYELVQQTRDPKVLQDQLLAIMLAGRDTTSSLLSFIFYELSRN
PGIWEKLKKEVYENFGSGTEKDIAKITFESLKKCNYVKWVINETLRMYPTVPVNLRVSNKDTLLPKGGGEDGKSPIFIPR
GTTVGFRVYSTQRNKEYYGEDPDVFRPERWADIGKLGWAYLPFLGGPRTCIGQQFALTEAGYILVRIAQLFPNLKSKNSV
HYPPKKTLNVIFNLFEGCLVEMGE
>CYP52A57 Pichia stipitis
62% to CYP52A39 Candida guilliermondii
JGI model
e_gww1.3.1.1392.1
MTVETIVQYLLCWQVYVLAVLVYHIFNWIHEQILYKKFGASPCINNERGGFLGIRLLRTLLKAKLDGTLSDVVKNRYYEM
EHPEIETFTLRVFSQTVIATRDPANLKAILATQFNDFSLGIRHAQLYPLLGDGIFTLDGEGWKHSRAMLRPQFAKEQIAH
VQSLEPHIQVLAKHIRKSEGKSFEMQELFFRLTLDCATEFLFGESVESLRDASIGMARADVEVEGKDRFAEAFNLAQTQI
ATRSMMNKMYFLYNTEELRNSCDVVHRFTDYYVNLALRTSTAELDKKSKSGYTFLYELVKQTRNPQILRDQLLNILLAGR
DTTAGLLSFAFFELARQPHIWAKLKDEIYSAFGSGENSRIDEITFESLKRCEYLKAVLNETLRMYPSVPNNGRIAVRNTT
LPRGGGPTGTEPMLVRKGQKVVYSVYTTHRSKTHYGEDAEVFRPERWFEPSSRKLGWAYLPFNGGPRICLGQQFALTEAS
YVVTRLIQMFPNISSDPTIEYPPRKASQLTMCLQDGLLISLY
>CYP52B1
C.tropicalis alk6 Z13013
MSLTETTATFIYNYWYIIFHLYFYTTSKIIKYHHTTYLMIKFKA
SPPLNYINKGFFGIQATFTELKHLICHTSIDYAIDQFNNVPFPHVHTFVTKVLGNELI
MTKDPENIKVLLRFPVFDKFDYGTRSSAVQPSLGMGIFTLEGENWKATRSVLRNMFDR
KSIDKVHDFEPHFKTLQKRIDGKVGYFDIQQEFLKLGLELSIEFIFGQVVSEDVPHYD
DFTQAWDRCQDYMMLRLLLGDFYWMANDWRYKQSNQIVQAFCDYLVQKSLENTCNDKF
VFVHQLAKHTTNKTFIRDQALSLIMASRDTTAELMAFTILELSRKSHHLGKLREEIDA
NFGLESPDLLTFDSLRKFKYVQAILNETLRMYPGVPRNMKTAKCTTTLPKGGGPDGQD
PILVKKGQSVGFISIATHLDPVLNFGSDAHVFRPDRWFDSSMKNLGCKYLPFNAGPRT
CLGQQYTLIEASYLLVRLAQTYETVESHPDSVYPPRKKALINMCAADGVDVKFHRL
>CYP52C1
C.tropicalis alk7 Z13014
MYQLFCFLAGIIVVYKAAQYYKRRTLVTKFHCKPARISPNKSWL
EYLGIASVVHADEMIRKGGLYSEIDGRFKSLDVSTFKSITLGKTTYVTKDIENIRHIL
SATEMNSWNLGARPIALRPFIGDGIFASEGQSWKHSRIMLRPVFAKEHVKQITSMEPY
VQLLIKIIKNHEGEPLEFQTLAHLFTIDYSTDFLLGESCDSLKDFLGEESNSTLDTSL
RLAFASQFNKTQQQMTIRFMLGKLAFLMYPKSFQYSIQMQKDFVDVYIDRVVGMSEEE
LNNHPKSYVLLYQLARQTKNRDILQDELMSILLAGRDTTASLLTFLFFELSHHPEVFN
KLKEEIERHFPDVESVTFGTIQRCDYLQWCINETMRLHPSVPFNFRTAANDTVIPRGG
GKSCTDPILVHKGEQVLFSFYSVNREEKYFGTNTDKFAPERWSESLRRTEFIPFSAGP
RACLGQQLPRVEASYVTIRLLQTFHGLHNASKQYPPNRVVAATMRLTDGCNVCFI
>CYP52C2
Candida maltosa D12718
MIDALYILIVALVIYKTAQFVHRKSLEKKHHCQPVKQIPLVSIL
SGLGFDMFFKDTAEMTKNGGLHKKLQQMLESLQTTTFRSRMLTGSQIVTMEPENERTM
CSSAHMKDWTIGYRPFALKPLLGDGIFSSEGESWKHSRIMLRPIFAKEHIKQITAMEP
YMLLLIEIIKSSSANEGPVDLQPLFHAFTIDYASDFLFGESCDVLKENLGGKSTSGMD
AQVKRDFASVFNDVQNYLTKRMMLGPLAFLVSSKDFHDGIKKQHEFVSYFVQKAISMS
DEELNDESKNYVFLYQLAKQTKDAKVLQDELLSILLAGRNTTASLLSFLFFELSHHEN
VWTTLKEVVDQSFPDVESITFETIQNCDYLRWCLFESLRVNPSVPFNSRTANKDTILP
RGGGEDCSHPILVKKGDQVLFPLYASNRQEKYFGRKPEEFIPERWRDLPKTGGPAFMP
FSTGPRMCLGQQFALIEASYVTIRLVQTFSKLKSHSLEYAPKRLVAATIRLIDGCFVS
FE
>CYP52C3 Candida albicans SC5314
60% to CYP52C2 orf19_6574
MLILLPIAVIAASIYYIAEYWKRESIKRKYDCQPVKQAPLVTWYDIFGIKALVDNSNLTKSGYFYQDIQRKLDNLDTTTM
KTTALGKNQIITIEPENFRTMCSSADLNNWTIGTRPIALKPLLGNGIFSSEGESWKHSRIMLRPIFAKEHIKQITAMESY
IQSLIKVIKLQQQGEGEFDLQHLFHCFTIDYATDFLFGESCDCLKSILGETSISTMSEEEKSKFAPNFDVMQYHMTKRLV
FGYFSFLVNPPEFKNAVKHLHEFVFHFVDRAINFTDEELNDPSKNYVFLYQLAKQTKDRKVILDELLSVLLAGRNTTASL
LSFMFFELAQNKPVWNKLKKEITEHFPDVESITFETIHNCEYLRWCIHESLRINPPVPINTRTANRDTVLPKGGGKGNNY
PIFVRKGEQVIFPLFSSNRQERFFGPEPEKYIPERWANLPRNGGVAFGPFGTGPRLCLGQQLALVEASYVTIRLLQTFSQ
LDSNHTECRRSVGATMRLMDGCQVTLK
>CYP52C4 Candida dublinensis
94% to CYP52C3 Candida albicans (ortholog)
cdub_588-g100.1
MLILLPVAVLAAIIYYIAEYWRKESIKRKYDCQPVKQAPLVTWYDIFGIKALIDNSNLTKSGYFYQDIQRKLDSLDTTTL
KTTALGKNQIITIEPENFRTMCSSADLNNWTIGTRPIALKPLLGNGIFSSEGESWKHSRIMLRPIFAKEHIKQITAMESY
IQLLIKVIKIQQQQQEEFDLQHLFHCFTIDYATDFLFGESCDCLKLILGETSISTMSEKEKSKFAPNFDIMQYHMTKRLV
FGYFSFLINPPEFQNAVKHLHEFVFHFVDRAINFTDEELNDPSKNYVFLYQLAKQTKDRKVILDELLSVLLAGRNTTASL
LSFMFFELAQNKPVWNKLKQEINQHFPDVESITFDTINNCEYLRWCIHESLRINPPVPINTRTANKDTVLPKGGGKGNNY
PIFVRKGEQVIFPLFSSNRQERFFGPEPEKYIPERWANLPRNGGIAFGPFGTGPRLCLGQQLALVEASYVTIRLLQTFSE
LDSNHTECRRLVGATMRLMDGCQVTLK
>CYP52C5 Candida parapsilosis
48% to CYP52C3 Candida albican
There is one 52C seq per Candida species
except this species has two. They
all seem to be orthologs even though the percent identity is not high
CPAG_01250
MNYILYSALAAIYIIYRVIDHVQVTRKAQKYGCKPVAQVPKRTLLSWLGLQLILNLKRNHERGRAHEALDEAFDRLKTTT
FATYVGIEPNVFTVEPENFRHMVSSSHTSEFNLGVRLDVFSILLGDGIFSSEGTSWKHSRIMLRPFFARENIKQIQSMEP
FTQSIIKAIKQAPGMTIDMQEIFQDFTMDYTTHFLLGESCGCLKTYLGEPTSDSISTEVKSSFAETFDKGAEYMLQKLVM
GRYHFLYRPKQLYVDVKNQHAFVDYYVQKALRMNQQDLKDSSNDGTLFLYDLAQQTKDPKVLRDEILSIIVAGRSTTSAL
MTFLFLELGRHQDVFERLKGIVRAHFPDIESITFESIQQCEYLRWCLNETLRHDPPVPFNSRTVTQDTILPKGGGQDNES
PIFVRKGTKIVYPLWTAHRMEKYFGKDPYTFNPDRWSSLPANGGFAFMPFGAGPRNCLGQQLALLETSYVTIRLLQTFNS
LKADSGEVRKKSTATMVLMDGCKLTFG
>CYP52C6 Candida parapsilosis
50% to CYP52C2 Candida
maltosa
CPAG_01665, 53% to to CYP52C5 this species
MTYIPYLIVIASYIIYKLLHRVQLHQRAIKLGCKPVKHIPPRNLLDRLGIYEIVHRKKLMHSGTTFEMLEEAFDRAQVKT
FEGTALFSSFIMTIEPENLRHMMSSAHFNEWNIGYRPQAFGILLGDGIFSSEGTQWKHSRVMLRPSFTKENIKQITKMEP
FAARVIDLIKQKSGQAIDMQDVFQFFTMDFTTDLLLGESSDSLKDALGQHSSTGIDPELKRQFSIAFDESSNYLMTRMIL
GPLMFLVNPKTLQDAIKIQHKFVDYYIEKALAMTSHELNEKSDDGTIFLYQLAHETKDPINLRNQILSIILAGRNTTSGL
MTFLFAQLSKNPEIYCKLRDIIRQDFPNVESITFDSIQNCDYLRWCINETLRINPSVPFESKTASVDTTLPRGGGVDEKA
PIFIAKGTRIVYPLWVANRNEEHFGENTGEFIPERWEQLPRSGGIAFMPFSVGPRACLGQSLALTEAAYITIRLLQTFDS
CESHLGPEPLRKTSSATMRLMDGCELSFK
>CYP52C7 Lodderomyces elongisporus
54% to CYP52C6 Candida parapsilosis
48% to CYP52C3 Candida albicans
LELG_05768
MMIHLPLFIVLTLLLVLYNIIRFYRKQVIKRKYKCQKIPNAQTSTFLSYLGLEFIVNYNKIQEEGRIHQNMYKQFKDLKT
STLAQTMLFLKVVFTTDPENYRYMSSSANFNNWTIGDRPDAFDPLLGDGIFSSSGESWKHSRIMLRPFFSKDHIKQIEYM
EPYVKDVVRLINIYQRDGVVVDMQDIFQYFTIDYATKFLLGESCDTLKDALDEPTSVTIDPELKSRFAKAFDISLKYLML
RVSLGKPLMWLVNPKELREANKIQHDFVRYYINKALAMNEEELNKHSDNGNCFLYEIAKQTKDPKILQDEVMSIILAGRN
TTSSLLSFLFFELSRDANKEILKKLVDAVRSNFDSIESITYEKIHNCDYLRWCLYETLRFHPSVPLASKTAAVDTILPKG
GGLDNESPVFVPKGRRVVYPLYTANRNSKFFGSDTEVYRPERFADLPKSGGPAFMPFSTGPRLCLGQQLALTEASYITIR
LLQTFDIIEKVGDEPYPPRTSSSATMRLMDGAKVRMRTSSSTTP
>CYP52D1
Candida maltosa D12716
MAIFTPELWLICFAVTVYIFDYIYTKYLMYKLGAKPITHVIDDG
FFGFRLPFLITLANNQGRLIEFSVKRFLSSPHQTFMNRAFGIPIILTRDPVNIKAMLA
VQFDEFSLGLRYNQFEPLLGNGIFTSDGEPWKHSRIMLRPQFIKSQVSHVNRLEPHFN
LLQKNITAQTDNYFDIQTLFFRFTLDTATEFLFGQSVHSLNDGENSLQFLEAFTKSQA
ILATRANLHELYFLADGIKFRQYNKMVQDFSQRCVDKVLNMSNSEIDKLDRYFFLYEM
VKITRNPQVLRDQCLNILLAGRDTTASLLSFAFFELALNEPIWIKLRTEVLHVFQTSL
ELITFDLLKTKCPYLQAILHETLRLYPSVPRNARFSKKNTTLPHGGGVDGMSPILIKK
GQPVAYFICATHVDEKFYTKDALIFRPERWCEEPLIKKNLAWSYLPFNGGPRICLGQQ
FALTEASYVLTRLAQCYTKISLQPNSFEYPPKKQVHLTMSLLDGVHVKISNLSIS
>CYP52D2 Candida tropicalis
AY230503
MAISSLLSWDVICVVFICVCVYFGYEYCYTKYLMHKHGAREIEN
VINDGFFGFRLPLLLMRASNEGRLIEFSVKRFESAPHPQNKTLVNRALSVPVILTKDP
VNIKAMLSTQFDDFSLGLRLHQFAPLLGKGIFTLDGPEWKQSRSMLRPQFAKDRVSHI
SDLEPHFVLLRKHIDGHNGDYFDIQELYFRFSMDVATGFLFGESVGSLKDEDARFSEA
FNESQKYLATRATLHELYFLCDGFRFRQYNKVVRKFCSQCVHKALDVAPEDTSEYVFL
RELVKHTRDPVVLQDQALNVLLAGRDTTASLLSFATFELARNDHMWRKLREEVISTMG
PSSDEITVAGLKSCRYLKAILNETLRLYPSVPRNARFATRNTTLPRGGGPDGSFPILI
RKGQPVGYFICATHLNEKVYGNDSHVFRPERWAALEGKSLGWSYLPFNGGPRSCLGQQ
FAILEASYVLARLTQCYTTIQLRTTEYPPKKLVHLTMSLLNGVYIRTRT
>CYP52E1
Candida apicola X76225
MIIGLSDAFALGGIALSFLVAYQFIYFYFIYSPRAKKLGCAPPV
IVFSFPLGLPALYKFATAMLHDNLLEYISIRIADMKVRTGFQTLAGQRWLVTLEPENI
KTVLATSFKDYSLGFRYDIMYGLLGNGIFTLSGDGWKHSRALLRPQFSREQVSHLESM
RTHINLMINNHFKGGQVVDAQALYHNLTIDTATEFLFGESTNTLDPDLAQQGLPGPKG
LVTGEQFAEAFTSALEILSVRVIVGAAWFLIWTPKFWRSCKVCHNFIDYFVYKALATP
MEKDQEADRYVFIRELTKETSDPRVIRDQALNILLAGRDTTAGLLSFITYYLGAYPEV
YAELREAVLSEFGSTDVETPTFEQLKQCKVLQNVIREVLRLHPNVPLNFRQAIVDTKL
PTGGGPNGDQPVFVPKGQNVFYSTYSMQRRTDIWGPDATTFRPDRWNEPREALASGWD
YIPFNGGPRICLGQQFALTEASYTIVRICQEFSRIEVLHPDVITSKNSMKQRMRLTQT
ASGGVITRFIR
>CYP52E2
Candida apicola X87640
MNINFSDALMLGGISLSFLLASQAIYFYFIYSPRAKKLGCAPPP
IFFSFPLGIPDLIRLVNAWFHDDLLEWFTHRFEEFGRRTAFQSVAGQLWIGTIEPENI
KTMLATSFKDYSLGFRYNAMYGLLGNGIFTLSGDGWKNSRALLRPQFSREQVSHLESM
RTHINMMINNHFKGGQVVDAQVLYHNLTIDTATEFLFGESTNTLDPALAQQGLPGPKG
LVTGEQFAEAFTSALELLSVRVMAGAAWFLVWTPKFWRSCKVCHNFIDYFVYKALATP
MEKGQDADRYVFIRELTKETSDPRVIRDQALNILLAGRDTTAALLSFTTYYLGAYPEV
YDELREAVIADFGSADAEPPTFEQLKQCKVLQNVIREVLRLHPNVPLNFREAIADTTF
PTGGGPNGDQPIFVPKGQKVFYATYVMQRNAGIWGPDSTSFRPDRWNEPREALASGWD
YIPFNGGPRICLGQQFALTEASYTLVRICQEFSRIEVLHPDVITARNVMKQRMRLPNS
SSGGVITRFIR
>CYP52E3 gene2 Candida bombicola 92% to 52E2, 82% to 52E1
EU552420 alternative name Starmerella bombicola
MNINFSDVLVLGGISVSFLLAYQAIYFYFIYSPRAKKLGCALPPVFFSFPLGIPEVXRLVNAWFNDDLLEYFTFKFEEFQRKTGFQSVAGQLWIGTIEPENIKTMLATSFKDYSLGFRYEAMYGLLGNGIFTLSGEGWKHSRALLRPQFSREQVSHLESMRTHINMLINNHFKGGKVVDAQVLFHNLTIDTATEFLFGESTNTLDPALAQHGFPGPKGLVTGEQFAEAFTSALELLSVRVMAGAAWFLVWTPKFWRSCKVCHNFIDYFVFKALATPMEKDQEADRYVFIRELTKETSDPRVIRDQALNILLAGRDTTAALLSFTTYYLGAYPEVYDELREAVIADFGKEDAEPPTFEQLKQCKVLQNVIREVLRLHPNVPLNFREAITDTKFPTGGGPNGDQPVFVPKGQKVFYATYVMQRNEGLWGPDSTTFRPDRWNESREAIASGWDYIPFNGGPRICLGQQFALTEASYTLVRICQEFSRIEVLHPDVITSRNVMKQRMRLTNSSSGGVIAKFIR
>CYP52F1
Yarrowia lipolytica gene for ALK1 AB010388
CAG80007.1
MSNALNLSLALGVFLLAYYGFSVIQYRIKTRKLEKKWKCGKPKD
ISRFPFSASFFIPFLVESKKNRLLEFVQWMFESQVYPGYTCKTTVFGVDMYHTVDPEN
LKAVLATQFKDFCLGERHAQFLPVLGNGIFTLDGQGWQHSRAMLRPQFARDQVSDVEM
IEEHIQYMTSRIPKDGSAFDAQELFFNLTLDTATEFLFGQSVGSQTVETNPTAVPTDM
PVHLRKSFQEDFNTAQEHLGQRARLQMFYWAWRPRELYSSGERVHAFVDHYVKKALEE
SEKHVDDGKYVFLRELAKETKDPIVLRDQALNILLAGRDTTASLLSWCLYLMARRPEV
YAKLREEVIENLGDGEDLSTITFESLKRCDYLRYVLNEVLRLYPSVPANMRYATRDTT
LPRGGGPDGMQPIVVRKGNLVSYHVFTTHRLKEFWGEDAEEFRPERWYEDGASQAKGW
EYLPFNGGPRICLGQQYALTEAGYALARIAQLYDTIENADDKPEPPVKFHALTMCHHT
GVLVKLYNSKTTKAQ
>CYP52F2
Yarrowia lipolytica gene for ALK2 AB010389
CAG77659.1
MIILYVLAVAVSFLIFKRVTYTMRSRELAKKWHCEEPHNLNEFP
LNLPLFFLIINASRRHELLDTLLGLFRSFAPTKTVKQVLLGSFTIIPTNDPENIKAVL
ATQFKDFCLGQRHGQLAPVLGDGIFTLDGQGWQHSRAMLRPQFARDQVSDVEMIERHV
QMMLLRIPNNKKFDIQELFFNLTLDTATEFLFGQTVGSQTVEMPNEDKSTVSDMPKDM
RKSFQEDFNVAQHHGGIRTRFQMFYWLWRPTELFSSSKRVHAFVDHYVEKALANSDEE
KSDDKYIFLRELAREVKDPRVLRDQALNILLAGRDTTAGVLSWIVYELARHPEVWKKL
RAEIHQDFGDGSDLSQITFEGLKRCEYLRFVINETLRLYPSVPLNVRYASRDTTLPRG
GGPDESKPILVRKGDTIVYNVFSMHRTEEFWGKDCDEFRPERWAEKGSRGWEYLPFNG
GPRICLGQQYALTETSYVITRICQLFTNIENADTAVEPPQKLHALTLCHLNGVFVKMT
RDEAAFAETEKLINA
>CYP52F3
Yarrowia lipolytica gene for ALK3 AB010390
CAG79910.1
MIIIETLIGAVVFVAVYVAFVKLDYYRRKAKFETSDMPVAYNGL
LGWKGLRHMLTVFNNDIGPVGWREVFATYGKTLKYYAFPSNTILTYDPDNIKAMLATQ
FKDFSLGLRKEALAPSLGYGIFTLDGSSWSHSRALLRPQFSREQISRLESVETHVQEM
MSCIDRNQGAYFDIQRLFFSLAMDTATDFLLGEAVGNLQEILHPEMPRTGTTFQVAFD
RAQRLGSLRIICQEAFWVVGSLFWRRDFNNTNQHIHDYVDRYVDKALLARKEKSEIYT
NPDKYIFLYELARETTNKITLRDQVLNILIAGRDTTASTLSWIFMELAKKPDIFHKLR
EAILNDFGTSCESISFESLKKCDYLRQVLNEGLRLHPVVPVNLRVAVRDTTLPRGGGP
QGDKPIFVAKGQKINYAIFWTHRDKEYWGEDAEEFRPERWETTSGGALGKGWEFLPFN
GGPRICLGQQFALTEMGYVITRLLQEYSDISIQPSDAAVKVRHSLTMCSAQGINISLT
RAKEE
>CYP52F4
Yarrowia lipolytica gene for ALK4 AB010391
CAG83106.1
MLTNLTIVLITLLVTYTVLTRTALRIQRARKAKQMGATLPPRVN
NGILGWYGLWLVIQNARSMKLPHTLGKRFANGPTWLTPVAGNEPINTIDPENVKAILA
TQFKDFCLGIRHRALSPSIGDGIFTLDGEGWTHSRALLRPQFSRQQISRVHSLERLMQ
ILFKLIRKENGEYFDLQNLFFMFTLDSATEFLYGASVDTLADLLGEPVEGDHGGVGEE
VRKAYQQSINNAQDISAIRTRLQGLYWIAGNIYQRNLYQKSNKGVKDFSQFFVDKALN
TSKEKLKEMEDSDNYVFLYELVKSTRNPVVIRDQLINILVAGRDTTASLLSFTFYTLG
RRPDVLKKLRAAILEDFGTSPDEITFESLKRCDYLRYVLNEVLRLYPSVPINARSATR
DTTLPRGGGPDGKQPVFVYKGQMVAYCVYWMHRDKKYWGEDALEFNPDRWDPKVQPQN
KGWEYLPFNGGPRICLGQQFALTEAGYVVTRMLQEFDTVHCKNQKEEEHPPYALDLTM
RHGEGVWVSMK
>CYP52F5
Yarrowia lipolytica gene for ALK5 AB010392
CAG83107.1
MLQLFGVLVLALTTALLAQLAYNKYEYNRKVKQFGCGELTVAKN
GFLGWKGIRAVLHVLKTKKGPAALKERIDAYGRTYVFHIGPAPVISTMEPENIKAMLA
TQFKDFSLGTRYRSLAPTLGDGIFTLDGHGWTHSRALLRPQFAREQVSRLDSLEAHFQ
ILKMCVDKEMREKGNDPRGFDIQNLFFLFTLDSATEFLFGSSVDSLVDFLDDPSVRTG
DHGGVDEAARKGFNNSFNHAQELCALRSRLHTLYWIVGSVVKKEPFERYNKEIKTFVD
FFAAKALKARKEKDMSLMDNDQYIFMYELVKETTNPVTLRDQMLNILLAGRDTTASML
SWIYFRLARDPKLYAKLRSAILEDFGTTPEAITFESLKQCDYLRYVLNEALRLYPVVP
INGRTATRDTTLPRGGGPDQSQPIFIPKGQTVSYSVYWTHRDPRFWGEDAEEFIPERW
DPRNGNIGRGWEYLPFNGGPRICLGQQFALTEVGYVLSRLVQTYETLETCDHKPLPPL
YNHALTMCHEEGVWVKMYKGEKA
>CYP52F6
Yarrowia lipolytica gene for ALK6 AB010393
CAG82620.1
MIQSVFLALAILIAYLGFAEWFSRFQHRRISKKKGCGMPPMANG
GFLGWYGLYKTYQITSERTYPHSMRMGLEAFGHTFVYPVPGTDMLQTIHPDNIKAILA
TQFKDFSLGTRHKIMLPTLGDGIFTLDGEGWTHSRALLRPQFARDQVSHVASLERHIQ
VLFKTIKKENKECDPAKGFDIQELFFMLTLDTATEFLCGDSVDSLTDYLADPTAPQLD
HSGIDENVRRAFPEAFNTAQWFCSIRAKLMKLYFFAGTVFYRKKYADANKIVHDFTDF
YVSKALAARKEKFQELDQEGKYIFLYELAKETRNPKVLRDQMLNILLAGRDTTASLLS
WVMFRMARQPETWKKLRQAVINDFGDTPDELSFESLKRCEYLRYVLNEGLRLYPSVPM
NFRVATRDTTLPKGGGPDLDQPIFIPKGGIVVYSVYHTHRAEEYWGKDTEEFIPERWD
PAEGYQIARGWEYLPFNGGPRICLGQQFALTEAGYVLARLAQEFETVTSCDDKPLPPK
YNTHLTMSHDDGVWLKME
>CYP52F7
Yarrowia lipolytica gene for ALK7 AB010394
CAG84028.1
MFQLFSILVLAFTTALVAQLAYNQYDYQRKVKKFGCGQLRVAEN
GLFGWKGLREVLRINKYKLGPAALKDRFEKYGKTHVFHVGPSPLITTMDPENIKAMLA
TQFKDFCLIARYKALGPMLGDGIFTLDGHGWTHSRALLRPQFAREQVSRLDSIEHHFQ
ILKKCISKEMSDKRDTQRGFDIQNLFFLMTLDTATEFLFGSSVDSLVDFLDDPSIQTG
DHGGIDEAARKGFSNAFNRAQELSSLRTRLHKLYWVIGTLAVREPYHRYNREVKTFVD
HYAAKAIKARNEKNTDLLDNDKYIFMYELVKETSNPITLRDQMLNILLAGRDTTASML
SWIYFRLARDPKRYAKLRAAVLADFGPGPENITFESLKKCDYLRYVLNESLRVYPVVP
INARTASRDTTLPRGGGPDGSQPIFVPKGQTVSYSVWWTHRDPEFWGQDAEEFIPERW
DTKNGSIGRGWEYLPFNGGPRICLGQQFALTEVGYVLSRMVQTYETLESGDTKPLPPL
YNHALTLCHQEGVWIKTE
>CYP52F8
Yarrowia lipolytica gene for ALK8 AB010395
CAG82058.1
MIPFTKINLELLLLPLLIIPITLFLLVLNVQVNTVHRRYKEYRL
KLARCPQQSTGLFGWWLIYAVVRCNRDRFYSAKVVDYFTKLRTFIVSLGGELVIYTSE
SENIKALLATQFSDYDLGKTRHALLFTLMGDGIFTLDGQGWAHSRALLRPQFSKETVS
PLSSLETSLQQLMAIVKRRVALKGEVDIQELFFMLTMDTATNLLYGESVDSLGDCLKE
TKKETHVMTDGKRNLLQSRDHHSNVPNEWEPIYGTYEKKGLGIGSENSLQSGVSPRDS
PVFEVSVSEDIRKAYPAALTTALEFSAMRSKLQRFYWIWGDVLYRQKFHSAVNTVHAF
SNHFVNQALKLTPQELQMKSAEKYTFLYELAQRTRDPVAIRDQLINILIAGRDTTAAL
LSFVFLCLVANPEKLAKLREGIMTDFGTSTDSITFESLKRCVYLRYVINEALRLCPPV
PINMRQANKDTTLPTGGGKNHDEPIFVAKNQIVTYSVLFMHHNQNIWGPDASEFRPER
WGEPACPKGWEYLPFNGGPRICLGQQYALTEAAYVIVRLVQEFTEIEWRDRKGLPVLF
KTHITMSLGEGLRVHMK
>CYP52F9
Yarrowia lipolytica
64% to CYP52F3
CAG84211.1
MLEILIGVTLFFTLWRVLVLADLKRRQKKSGYGYPPIASNGLLGWRGLVHQLSGFVKDIGPAGWGAQFKEHGKTHLYPVF
PTQLLVTRDPDNVKAILATQFKDFSFGIRKEALCPSLGYGIFTVEGSSWSHSRALLRPQFSREQISRLDSVEHHFQEFAQ
CVDNFKGEYFDIQKLFFAQSMDTSTDFLLGESVGCLKELLETRDGDESSKKFGANFQHAFDRVQRLVALRVVFQENYWII
GDVFFRNEFRQVNELIQKFVQGYVDKALKARAHKAPIYTNPDKYIFLYELARDTTNPRVLRDQVLNILIAGRDTTAATLS
WLMFELAQKPHIFHKLRKAVIEDFGTTIENISFESLKQCEYLRYVLNEVLRLHPVVPINLRVALKDTTLPRGGGPNGDEP
IFVPKGQKINYAVYWTHRDEQYWGEDAEEFKPERWDTTNHPGPLGKGWEFLPFNGGPRICLGQQFALTEMGYILTRLVQE
YSDIGIDEEYHDRPLRVRHSITMSHGDGVHVRLSREGTVVS
>CYP52F10
Yarrowia lipolytica
71% to CYP52F1
CAG82791.1
MLGRTLLVSDHCVDITASIFPGSSHPFTTTNPAMNTFHLLIALATFVVVYILSSSFVYQRRTNALEKQWKCGKPLYYASF
PRSLWHFYVFLRESRKHKLLEGFQRSFEAKKPFLTNKVNIFGKDIFNTCDPENLKAMLATQFKDFCLGERHAQLFPVLGD
GIFTLDGNGWQHSRAMLRPQFARDQVSDVHMVETHLKFLTSRITGSKPVDMQELFFNLTLDTATEFLFGQSVGCQIAESD
PGAYSSDMPLDLRKSFQKDFNKAQEHLGERVRLQMLYWLWNPKELQTAGARVHAFVDHYVSKALVEAEEKVDDDKYVFLR
ELARETKDPKVLRDQALNILLAGRDTTASLLSWCFYLMARDDRVWQKLRSEVIEHFGDGENLENITFESLKRCDYLRYVL
NEVLRLYPSVPANMRFATKDTTLPRGGGPVGQDPIVIRKGNVISYHVFTTHRLTQYWGEDAEEFVPERWAEGKARGWEYL
PFNGGPRICLGQQYALTEAGYVLVRLAQMYDTLENADDKPEPPVKLHALTMSHLTGVHVKLYKKN
>CYP52F11
Yarrowia lipolytica
69% to CYP52F2
CAG83401.1
MILLYVLAFLVSYLIFTRLRYRYQSYKLAQKWKCSPVRDVSSFPMAFPEFLFFFKSGKNNVLLDEFVNFFTKRQPNLTVG
LVLAGNDVTVTLEPENLKALLATQFKDFCLGVRHNQLAPILGDGIFTLDGQGWQHSRAMLRPQFARDQVSDVDMIERHVQ
NLVRKIPQGDSFDIQGLFFNLTLDTATEFLFGQSVSCQTVDNPAEDDSTVTDMPIPMRKSFQSDFNLAQHHGGYRVRLQM
FYWLWRPQELFTASKSVRKFVDHYVKKALVESEKEKQADDKYVFLTELAREVKSPQVLSDQALNILLAGRDTTASLLSWC
IYLLARHPETWNKLRDEILSTFGSGSDLSLITFESLKRCEYLRFVINETLRLYPSVPVNVRYATRDTTLPRGGGPDESQP
ILIRKNSVLVYSVFATHRLKKFWGEDADEFRPERWGEGISRGWEYLPFNGGPRICLGQQYALTETSYVLTRIVQLFGTLE
NADASPEPPMKLHALTMCHLTGVHVKMSTNNLP
>CYP52G1 Aspergillus nidulans AN6057.1 38%
to 539A1 46% to 52F1 52 clan
MLFLSVLLAFAAYLLIYQYAMTNWNHARRARLWGCSPLPRYPTDILGLAT
LRESLKADKEKKIPLLLQNRLKRMSAREKRPVTTFVIRQMGLDNIFTCDH
GNVQAILATKFKNFELGVGRRHTLYPMFGVGIFTSDGETWSRSRALLRPQ
FTRDQISDLDLEESHVQQAMRAMNVDPATGWTSSIDIQAIMFRLTIDSAT
EFLFGESAGSQAEALRNGGTLPLNHFSGDFDLGQWYVAQRSRFEKFYWLV
DNRESRAVVKRVHEYVDRFVHAVLTTAEDRIEKSQSSSYVFLEALAASTK
DPIELRSQLLNILLAGRDTTASLLSWSILMLARYPEVFTKLRSVILADFG
SYTSSRDKITFASLKSCRYLQYFLNEVLRLYPAVPINRRVATTATTLPKG
GGPAGDKPIYLRAGQVVTYSPFVTHRRTDLWGEDAEVFNPERWVNKKVGW
EYLPFNGGPRVCIGQQFALTEAGYVIVRLLQRFDAIMDCFPEREIRYGLT
LTLAPADGVFVRLHAAE*
>CYP52G2 Aspergillus fumigatus Af293
GenEMBL
XP_755288.1 also EAL93250.1
60% to 52G1
MGLPLLTIAAVAVALRLLWTLAARWQHAQNARRLGCGSIPLYPSDPLGISVLKETLAADKAKKLLPLVER
RVALMSDREGRYVTTFRFRQMGRENYFTTDPKNIQAILATQFKDFELGAPRRQALHPLLGAGIFSSDGEE
WFHARGLLRPQFTRDQISDLDLEERHVQKAMQAMPVVNGKWTDAVDIQSIFFRLTIDSATEFLFGESVES
QLSALNGGQTPVDTFPYYFDKSQWYAAQRARFEKLYWIVNNKECRHAQNEVHAYVDRVVHKALKAAREGK
LANPNKPSQYVFLHALVSVTQDPIELRSQLLNILLAGRDTTASLLSWTVLMLARHPAEFHKLRQTIVDEF
GTYDQPRNITFAALKSCQYLQYCLNETLRLFPVVPGNRRSATRDTTLPRGGGSDGTQPIYIRKGQTVVYN
VHILHRRKDIWGPDAEEFKPSRWVDRKVGWDYVPFNGGPRICIGQQFALTEAGYVLVRLLQRFDAIEDMQ
PHLEIRHSLNLTSAPADNVTVRLREAA
>CYP52G2 Neosartorya fischeri
97% to CYP52G2 Aspergillus fumigatus =
ortholog
NFIA_085030
MGLPLLTIAAVAVALRLLWTLVTRWQHAQNARRLGCGSIPLYPSDPLGISVLKEALAADKAKKLLPMVERRVALMSDREG
RYVTTFRFRQMGRENYFTTDPKNIQAILATQFKDFELGAPRRQALHPLLGAGIFSSDGEEWSHARGLLRPQFTRDQISDL
DLEERHVQKAMQAMPVVNGKWTDAVDIQSIFFRLTIDSATEFLFGESVESQLSALNGGQTPVDKFPYYFDKSQWYAAQRA
RFEKLYWIVNNKECRHAENEVHAYVDRVVHKALKAAREGKLANPDKSSQYVFLHALVSVTQDPIELRSQLLNILLAGRDT
TASLLSWTVLMLARHPAEFHKLRQTIVDEFGTYDQPRNITFAALKSCQYLQYCLNETLRLFPVVPGNRRSATRDTTLPRG
GGSDGTQPIYIRKGQPVVYNVHILHRRRDVWGPDAEEFKPSRWVDRKVGWDYVPFNGGPRICIGQQFALTEAGYVLVRLL
QRFDAIEDVQPHLEIRHSLNLTSAPADNVTVRLREAA*
>CYP52G3 Aspergillus oryzae
GenEMBL
BAE65166.1, AP007171.1
58% to CYP52G4,
63% to 52G1
14 P450 genes and
2 pseudogenes on this contig
MIPLLILAALAVVFRLVWSIFTSLRHAQNARKWHCGAIPTYPGDILGINTLKEVLRADKEKLIPVLSAQR
VETMTAREGRYVSTFRLRQMGRESIFTSDPKNMQAILATQFKEFELGSLRRNSLHPLLGSGIFSTDGEAW
SRSRSLLRPQFTRDQVSDLDLEERHVQKAMAGMLADPATKWTPEIDIQSIFFRLTIDSATEFLFGDSVES
QTAALSGSRIIEDKFPSYFDRGQWYAAQRARFEKLYWIVNNKESRETDRFVHAYVDRFIDAALAAVKEGK
IDPEKRNSDHYVFLHGLTTATQDPVELRSQLLNILLAGRDTTASLLSWCVLLLARHPDIFQKLRNTILAD
FGDYRNPRNITFSSLKSCRYLHYFMNEVLRLYPIVPGNRRVALKDTTLPRGGGPDGSEPVYVRKGQPVVY
SVFVTHRRKDIWGADAEVFNPDRWEDLKVGWEYLPFNGGPRICIGQQFALTEAGYVLVRLLQRFDQIVDA
RPEREIRFNATLTSAPWENVIVRLREGA
>CYP52G3 Aspergillus flavus
99% to CYP52G3 Aspergillus oryzae
AFL2G_05445
MIPLLILAALAVVFRLVWSIFTSLRHAQNARKWHCGAIPTYPGDILGINTLKEVLRADKEKLIPVLSAQRVETMTAREGR
YVSTFRLRQMGRESIFTSDPKNMQAILATQFKEFELGSLRRNSLHPLLGSGIFSTDGEAWSRSRSLLRPQFTRDQVSDLD
LEERHVQKAMAGMLADPATKWTPEIDIQSIFFRLTIDSATEFLFGDSVESQTAALSGSRIIEDKFPSYFDRGQWYAAQRA
RFEKLYWIVNNKESRETDRFVHAYVDRFVDAALAAVKEGKIDPEKRNSDHYVFLHGLTTATQDPVELRSQLLNILLAGRD
TTASLLSWCVLLLARHPDIFQKLRNTILADFGDYRNPRNITFSSLKSCRYLHYFMNEVLRLYPIVPGNRRVALKDTTLPR
GGGPDGSEPVYVRKGQPVVYSVFVTHRRKDIWGADAEVFNPDRWEDLKVGWEYLPFNGGPRICIGQQFALTEAGYVLVRL
LQRFDQIVDARPEREIRFNATLTSAPWENVIVRLREGA*
>CYP52G4 Aspergillus oryzae
GenEMBL BAE55312.1
54% to 52G1
MSDARTTLMETWFTPALVAAIVAARLLFSLYSAWRHAQRARSLNCQEAPLYPSRDPFGVATLLETLRADR
DKFLPKLSQKRVDLISSQQNRYVSTFRVRQAGRENFFTVDPKNIQAMLATQFNDFFLGDMRRNAGAPVIR
SGIFVSDGADWSHSRSLIRPQFTRTQINNLELEERHVQNALRAMPTQSNGWTSEVDIQTILFRLTLDSAT
EFLFGKSCNSQLTALEKDAGEMSDSFLNSFDRCAWYLAARLRFERLYWIVNNKEFRECTRVVHELVDGYV
HAALQRAQQAEKPADPERGSHYVFVDALTATTQDPNQLRDECLNVLIAGCDTTASLLSWNILLLARHPDI
FQRLRKEIIERFGTYSEPRDINFSSLKSCQYLQHFINETLRLHPVVPFNRRCANKDTTLPRGGGKDGNSP
VYLQKGQPVLYSSYVLQRRKDIWGEDAEEFNPDRWYGRKAIWEHIPFSGGPRTCIGQQFAITNTSFVLVR
LLQRFDSIEDVYPEREIRYGVTLTNCPADRVTVRMHQAEL
>CYP52G4 Aspergillus flavus
99% to CYP52G4 Aspergillus oryzae
AFL2G_00228
METWFTPALVAAIVAARLLFSLYSAWRHAQRARSLNCQEAPLYPSRDPFGVATLLETLRADRDKFLPKLSQKRVDLISSQ
QNRYVSTFRVRQAGRENFFTVDPKNIQAMLATQFNDFFLGDMRRNAGAPVIRSGIFVSDGADWSHSRSLIRPQFTRTQIN
NLELEERHVQNALRAMPTQSNGWTSEVDIQTILFRLTLDSATEFLFGKSCNSQLTALEKDAGEMSDSFLNSFDRCAWYLA
ARLRFERLYWIVNNKEFRECTRVVHELVDGYVHAALQRAQQAEKPADPERGSHYVFVDALTATTQDPNQLRDECLNVLIA
GRDTTASLLSWNILLLARHPDIFQRLRKEIIERFGTYSEPRDINFSSLKSCQYLQHFINETLRLHPVVPFNRRCANKDTT
LPRGGGKDGNSPVYLQKGQPVLYSSYVLQRRKDIWGEDAEEFNPDRWYGRKAIWEHIPFSGGPRTCIGQQFAITNTSFVL
VRLLQRFDSIEDVYPEREIRYGVTLTNCPADRVTVRMHQAEL*
>CYP52G5P old name = CYP-un1
pseudogene Nectria haematococca e_gw1.8.757.1
Necha1/scaffold_8:999970-1000262
PSEUDOGENE very short piece
57% to 538A3, 54% to 584D1, 61% to 52A3, 68% to
52G2
DESLRLYPVEPINARYANKDTTLPRGGGKDGNSPILIPKGSSTAFSVHIIHRRKDIRGPD
ANEFKPERWEGRRVGWEYVP ()
FNGGPRICIG**FALIGASYVTVRLLQRFDKMESLEKDAVVRHNLKLINYVANGVKVRLHAAS
>CYP52G6 Aspergillus niger
fgenesh1_pg.C_scaffold_15000225|Aspni1
57% to CYP52G2
MGLATLLLVLVGLTFILRIVSEKWRHRQNAKRLGCQPAPMAPSKDPLAIGDILEIIQADKDKVVPELLESRTNIMRDNNA
GRYVSTFRLKRGLGENLLTFDPENLQAMLAKQFKDFSVGGERLGCMGPLLGKGIFINDGAEWSHSRTMLRPQFTREQISD
LGLEERHVQNAMRAIPAAGSNGWTEVDIQSIYFRLTLDSATELLFGESCYSQLAAMGDAEDRMASGGKVTDFGKNFDRAQ
WYMAQRLRLPRMKFLYDNKEFRTCCQEVHRFVDECVAKALHDHKKKKQQQQLLEEGASEHYIFVHAMAETTKDPIELRSQ
LLNVLLAGRDTTAALLSWTTLLLSRHPEVFHKLREAIIADFGTYENPQNITFATLKACTYLQQVMNETLRLFPPLPTNAR
YATKDTSLPRGGGPDGQSPVYIKKGQAVLYNVHMLHRREDVWGKDAKEFKPERWEARRSGWEYLPFNGGPRICIGQQFAL
TEAGYVLVRMLQRFDGIEDVHADQRIRWGLTLVSAPGDTVTVRLHEASR*
>CYP52G7 Aspergillus niger
e_gw1.7.657.1|Aspni1
67% to CYP52G3
MSTLLFVATASPILYLLYVLLSRWQHAQNARKWNCGSVPSYPGDLLGINTLKEALAMDKARQVPTVTRRRVETMSARENR
YTTTFQFRQLGTDVISTCDPKNVQALLATQFKDFELGQSRRNALHWLLGRGIFTADGDHWSRSRALLRPQFTRDQISDLD
LEERHVQVAMKAMPVDATGWTPATDIQTIFFRLTMDTATEFLFGESVQSQAAALSNGAIPQDDFPAQFDRGQWYSAQRAR
FEKLYWIINNKESRAINKAVHAYVDRFVTAALNSDPEKKPTGHYVFLHGLAEATRDPVELRSQLLNILLAGRDTTASLLS
WCVLFLARHPAYFSSLRATILAEFGSYSSPRDITFANLKSCRPLQNFLNEVLRLYPIVPGNRRTAVRNTTLPTGGGPAGT
DPVYVKKGQPVFYSTYVMHRRPDLWGADADEFRPDRWNERKAGWEYLPFNGGPRICIGQQFALTETGYVLVRLLQRFDVI
EGVGKTKEGEINMQMSLTNAPGDNVTVRLHEDASN*
>CYP52G8 Aspergillus clavatus
83% to CYP52G2
ACLA_081330
MAFPLVTIAAVAVALRLLWVLVSKWQNAQNARRLGCGSTPLYPSDFIGISVLKEALKADKAKQLLQLIERRVALMSDREG
RYVSTFRLRQIGREMYFTTDPKNIQAVLATQFKDFELGAPRRNAIHSLLGTGIFTSDGEEWSRSRALLRPQFTRGQISDL
ELEERHVQNAMRAMRVVNDKWTDAVDIQSIFFRLTIDSATEFLFGESVESQLSALNGGGTPADQFPYYFDRSQWYCAQRG
RFEKLWWVVNNRESRHAEKEVHAYVDRFAQNAIKTAQEGKLATDDSSRYVFLHALASVTQDPVELRSQLLNILLAGRDTT
ASLLSWTMLLLARHPAEFQKLRQAVVDEFGTYDQPRNLTFGALKSCQPLQHCMNEVLRLFPVVPGNRRIATKDTTLPRGG
GSDGSQPIYVRKGQPVAYSMHILHRRKDIWGPDAEEFKPSRWVDRKVGWDYVPFNGGPRICLGQQFALTEAGYVLVRLLQ
RFDAIEDVQPHLEIRYALNLTSAPADNVTVRLREASK*
>CYP52G9 Aspergillus terreus NIH2624
CH476602
62% to CYP52G2
complement(join(1144551..1145711,1145779..1146177))
ATEG_06678
GenPept EAU33222.1
MATLLSISVLAVVVLRLFWTLAAKFNHARKARRWGCAPYPTYPS
DLLGIGLLKETLAADKADVLCPMFERRIAHISAREGRHVATLSWMSLGRETCFTIDPE
NVRAVWATQFKDFVAGDLRWNVSHQLTGKNIASTDGAEWARYRALLRPQFSRSQISDL
DLEERHVQKVMLAIPVINGKWTEPVDIQEIFHRFTIDSSTEFLFGKSVESQISAITGQ
KTAEADFAHHLDKSMEYIGKRARLDKLYWLANNQESRFSESEVHKYVDRYVQDAIKAG
QEGKLQADPERSPQYILLHALTTATQDPIELRNQVLTLLLAGRDTTASLLSWTVLLLA
RHADEFQKLRQAVLEDFGSYDNPHNLTFGALKSCSHLRHCLNESLRLYPVAPFNRRIA
VRDTTLPRGGGSDGRQPIFVRKGQAIMFSAYSMHRRRDIWGPDADDFRPGRWEARKTL
WEYLPFSGGPRICLGQQFALTEAGYVLVRLVQRFDAMEDVNAETEIKQKVTLTSAPAQ
SVTVRLHAPRA*
>CYP52G10 Aspergillus terreus
68% to CYP52G4
ATEG_07540.1
MHTLLFVPALVLAGIAVRLVISFALSWRKARNARRLGCEEAPLYPSKDPFGFSNLLETLRADRAKVLPELAERRIDLLSQ
RHGRYISTFRVRQPGKESLFTADPKNIQAMLATQFKDFGLGDGRRNVGGPLVGRGIFTTDGEAWSHSRSLLRPQFTRAQV
SNLDMEERHVQNAMRALPVLSNGWTRAVDIQTIFFRLTLDSATEFLFGKSCDSQLAAVRTDVGRGSDSFLYGFDRSVWYL
SERLRFDRFYWLVDNREFRESIRMVHAFVDKYVNAVLERQAGDTKLPDSSQSTSQYVFLEALAASSKDPLQLRYESLNVL
LAGRDTTASLLSWAVLILARRPDIFSRLRKDIVEQFGTYKTPRGITFASLKSCQYLQHFINETLRLYPVVPFNRRCALRD
TTLPSGGGKDGSSPIYIPKGQQVLYGSYVLQRRKDIWGDDAEAFNPDRWIGRKVTWEYIPFNGGPRTCIGQQFALIKTSY
VLVRLLQRFDSIVDVHADQEIRYGVALTCAPADLVTVKLHEADD
>CYP52H1 Aspergillus nidulans AN7131.1 45%
to 584B1 52 clan
MWSPFLEVAKALREGHVVEFITQKYNEYGWTFEQNVLGRSGISTIEPENL
KALLATQFNDFCLGTREREFGPLLGQGIFTLDGAGWSHSRALLRPQFTRD
QVADLDLMESHISRLIELVPKDGSAFDIQRLFFLMTLDSSTHFLFGESVH
CMDEGNVLARSTVNNAQGFANAFNTALDYLNWRSVAGNFYWMITSKEFRD
ANKRVHEVVDYYVHQAIEAKRHPEKKEPGRYIFAEALAADNDNPKVLRDN
MLNILLAGRDTTASLLSSAFFYLSRHPAVWEKLRRVIIEEFGDVQNPKGE
ITHAKLKDLPYLRYVLNEVLRLQPPVPLNLRVAVKDTSLPVGGGPDGKSP
VFVEKDQPVLYSVYAMHRRKDLWGPDADSFRPERWEENAKHGWEYLPFNG
GPRICLGQQYALTEASYTMVRLMQRFSKVENGEPGLDEPLIRATLTMSHE
NGVKVRFKLQHVRRKPSPLQTCTR*
>CYP52H2 Aspergillus fumigatus Af293
GenEMBL
XP_746567.1 also EAL84529.1
cytochrome P450
alkane hydroxylase
72% to 52H1
MLAPAVALFAAVYTTFLVLRYFQQLYKHRKQARSLRCQPPADGEAGFLGIASFLRLRKAAKEKRWIELIA
EQYGKYGNTFTQTIFGQPLVSTIEPENLKALLATQFNDFELGTRHREFYPLLGDGIFTLDGAGWSHARAL
LRPQFTRDQVADLDLMDGHVSRLIDLVPKDGSAFDIQRLFFLLTIDSATHFLFGESVGSLHAGTDTGLLG
RSAVGNAEGFAEAFNKAQEYLAARSRAVVFYWMINPKEFRDANKRVHEVVDHYVQLALESRRNPEKKQPG
GRYIFAEALAAENDNPKVLRDNMLNILLAGRDTTASLLSSTFFYLARHPNVWIKLRQVIVDAFGDAEHPK
EEITQTKLKDIPYLRYVLNEVLRLLPPVPANFRVANKDTTLPVGGGPDQKSPVYIRKGTIVTYSVYAMHR
RTDFYGPDANEFRPERWEENGKRGWEYLPFNGGPRICLGQQYALTEASFTIVKLLQRFDRIENGDPDLIE
PIQQTNLTLAHDRGVYIRLYSSKAL
>CYP52H2 Neosartorya fischeri
95% to CYP52H2 Aspergillus fumigatus =
ortholog
NFIA_029600
MLAPAVALFGAVYATFLVLRYFQQLYKHRKQARSLRCQPPAEGEAGIFGISSFLRLRNAVKEKRWIELIAEQYGKYGNTF
TQTIFGQPLVSTIEPENLKALLATQFNDFELGTRHQEFYPLLGDGIFTLDGAGWSHARALLRPQFTRDQVADLDLMDGHV
SRLIDLVPKDGSTFDIQRLFFLLTIDSATHFLFGESVGSLHAGTDTGLLGRSAVGNAEGFAEAFNKAQEYLAARSRAVIF
YWMINPKEFRDANKRVHEVVDHYVELALESRRNSENKQPGGRYIFAEALAAENDNPKVLRDNMLNILLAGRDTTASLLSS
TFFYLARHPNVWTKLRQAIVDAFGGAEHPKEEITQTKLKDIPYLRYVLNEVLRLLPPVPANFRVANKDTTLPVGGGPDQK
SPVYIRKDTVVTYSVYAMHRRTDFYGPDANEFRPERWEENGKRGWEYLPFNGGPRICLGQQYALTEASFTIVKLLQRFDR
IENADPDLIEPVQQTNLTLAHDRGVYIRLYSSKAL*
>CYP52H3 Aspergillus oryzae
GenEMBL
BAE64862.1, AP007171.1
71% to 52H1, 48%
to 584G1
14 P450 genes and
2 pseudogenes on this contig
MLAQIAPLFGALCITFLVLQYLQRLYQQRKRAQSLGCQPAAQGPSGIFGIRSFVRLLNEVRHKRWVEYIA
GQYGRYGNTYTQKALGKWMVS TIEPENIKALLATQFNDFGLGTRHREFYPLLGDGIFTLDGPGWSHARGL
LRPQFTRDQVADLELMDGHISRMIDLIPQDGSSFDIQRLFFLLTIDSATHFLFGESVGALESSNSASLLG
RSSVGSAQGFAEAFGTAQDYLTTRSRAMHFYWMVNPKEFREANQRVHEVVDHYVQLAIQSKNNPDKKSDR
YIFAEALAADNDDPKVLRDNMLNILVAGRDTTASLLSSAFFYLSRNQDVWKKLRQTIIDEFGDSQNPKGE
ITQAKLKDIPYLRYVLNEVLRLLPPVPLNFRVAAKDTSLPVGGGPDGRSPVFIPKGQVVAYSVYAMHRRT
DLYGPDSHSFRPERWEENGRRGWDYLPFNGGPRICLGQQYALTEASYTLVKLVQRFDTLECADPELKQPA
ILSTLTMSHDRGVKVRLSSSVPKCWFNQ
>CYP52H3 Aspergillus flavus
100% to CYP52H3 Aspergillus oryzae
AFL2G_05134
MLAQIAPLFGALCITFLVLQYLQRLYQQRKRAQSLGCQPAAQGPSGIFGIRSFVRLLNEVRHKRWVEYIAGQYGRYGNTY
TQKALGKWMVSTIEPENIKALLATQFNDFGLGTRHREFYPLLGDGIFTLDGPGWSHARGLLRPQFTRDQVADLELMDGHI
SRMIDLIPQDGSSFDIQRLFFLLTIDSATHFLFGESVGALESSNSASLLGRSSVGSAQGFAEAFGTAQDYLTTRSRAMHF
YWMVNPKEFREANQRVHEVVDHYVQLAIQSKNNPDKKSDRYIFAEALAADNDDPKVLRDNMLNILVAGRDTTASLLSSAF
FYLSRNQDVWKKLRQTIIDEFGDSQNPKGEITQAKLKDIPYLRYVLNEVLRLLPPVPLNFRVAAKDTSLPVGGGPDGRSP
VFIPKGQVVAYSVYAMHRRTDLYGPDSHSFRPERWEENGRRGWDYLPFNGGPRICLGQQYALTEASYTLVKLVQRFDTLE
CADPELKQPAILSTLTMSHDRGVKVRLSSSVPKC*
>CYP52H4 Aspergillus niger
estExt_GeneWisePlus.C_80246|Aspni1
73% to CYP52H2
MLAPAIVFLGAIYLTFRILSSLHQAYHHRKKAKALGCQPPNSVDTGILGITGFYRIAKAAREKRWVEYIAEHYQTSGPTF
RQRALGGLMVTNTVEPENIKALLATQFQDFGLGTRHREFYPLLGNGIFTLDGAGWSHARGMLRPQFTRDQVADLDLMDGH
ITKMMDLIPKDGSTFDIQRLFFLLTIDSATHFLFGESVGSMRTSAESSLLEKSTVGNAQGFAEAFNRAQEYLAARSRAMA
FYWLVNPKEFREANQLVHEVVDHYVRLALEAKRHPEKKEPGRYIFAEALAGDTDDPRVIRDNMLNILLAGRDTTASLLSS
AFFYLARHPNVWTRLRQTIVDEFGDAQHPKGTITHARLKDTPYLRYFLNEVLRLLPPVPLNFRVAAKDTSLPLGGGPDGK
APIYVRKGELVSYSVYAMHRRTDLYGPDAHAFRPERWEENSKRGWEYLPFNGGPRICLGQQYALTEASYTMVKLLQRYNR
IENADPDMVEPIINSSLTLSHDRGVHIRLFSS*
>CYP52H5 Aspergillus clavatus
84% to CYP52H2 Aspergillus fumigatus
ACLA_054640
MLAPAVTLLVAVYAAFLILRYFQQLYHHRKQARALRCQPVASGNPGFFGIPAFLRLGQAVKEKRWIEHITEQYGTYGNTF
TQVLLGRRLLSTIEPENLKAMLATQFHDFGLGTRHREFYPLLGDGIFTLDGPGWSHARGLLRPQFTRDQVADLDLMDGHI
SRLIELVPKDGSTFDIQRLFFLLTIDSATHFLFGESVGSLHGGTDTGLLGKSAVGNAQGFAEAFNTAQEYLLTRSRALDF
YWMVNPKEFRDANKRVHEVVDHYVQLALESRRNPEKKKQSGGRYIFAEALAAENDNPKVLRDNMLNILLAGRDTTASLLS
STFFYLARHPNVWTKLRHAIVEEFGDSENPRNEITQTKLKDIPYLRYVLNEVLRLNPPVPANFRVANKDTSLPVGGGPDK
KSPVYVPKGTVVTYSVYAMHRRTDLYGQDADQFRPERWEENGRRGWEYLPFNGGPRICLGQQYALTEASYTVVKLLQRFD
TIENADPGLLVPIQLSNLTMSHDTGVNIRLYSSKGYN*
>CYP52H6 Aspergillus terreus
75% to CYP52H5
ATEG_02198.1
MLAPIGLVFGALYLTYFVLQYIQRLYQQRKFAKARQCLPPREGAAGLFGITPFIRLAKAVREKRWVEYIADQYSINGTTF
SQAMLGQRMISTIDPENLKAILATQFNDFSLGTRHREFYPLLGDGIFTLDGAGWSHARGLLRPQFTRDQVADLDLMNGHV
SRLIELVPKDRSTFDIQHLFFLLTIDSATHFLFGESVNSMGSGVLEKSAVGGAQGFAEAFNTAQDYLASRSRAMKFYWMV
NPKEFKDATARVHEVVDHYVRLAIESKNHPERKEAGRYIFAEALAADNDDPKVLRDNMLNILLAGRDTTASLLSSTFFFL
ARSPKVWNRLRETIINEFGDSQNPKSEITHTKLKDIPYLRYVLNEVLRLMPPVPLNFRTATKDTSLPVGGGPDGRSPVFV
PKGTTVTYSVYAMHRRPDFYGPDPNEFRPERWEENGRRGWDYLPFNGGPRICLGQQYALTEASYTLVKLLQHFDTLENAD
PTLLRPVIQSNLTMSHETGVNVRLYRAGTA
>CYP52J1P Aspergillus
fumigatus Af293
GenEMBL
XP_746816.1 also EAL84778.1
alkane hydroxylase
predicted
42% to CYP52F1, in
52 clan
insertion of 11 C
bases causes frameshift
MTNTDIAFGHQHGCELPPELTKNWPLGLDRIKELWTANTEGHLLAFLCSVAEKYEPGNSITQYFLFGPRA
FHILQPESVEAILSTNFKDYGFGARAAIFAPRLGNGIFTQEGPAWRHSRDLLRKQFSRVQNRILEHFHEH
VDNMVARLPLDGVVDLQPLFFNLTLDIATALLFGRSVYSLLAGIDQDADNGLFAEGFNIAQDGLAKRFRI
APWHFLYNPPGFRKACGDVHRFVEQYIDQLDLENSEDLDDKTYGFIKRVAHESASRQHLRDQLLNVLLAG
RDTTACCLSWTFRLLVHHEQAMIRLREEIASVMGDSAHPTKEQIRKMPYLSCVIKE
(1)
SLRLYPPP &
PPVPLNNREAIRTTILPTGGGPDADRPILVRKGELVVFFQYVNSRKKNIYGPDADCFRP
ERWETGELDHIGWAYFPFNGGPRQCLGENFALMEVSYTVVRLLQTFSSIILPKGQPIEPVGSERQRLTLV
LSSADGCKVQIHS
>CYP52J1 Neosartorya fischeri
95% to CYP52J1 Aspergillus fumigatus =
ortholog
NFIA_113870
MQSSQQDNALGHQHGCELPPELTKKWPLGLDRIKELWTSNAEGHLLAFLCSVAEKYEPGNSITQYFLFGPRAFHILQPEN
VEAILSTNFKDYGFGARAAIFAPLLGNGIFTQEGPAWRHSRDLLRKQFSRVQNRNLEHFHEHVDNMVARLPLDGVVDLQP
LFFNLTLDIATALLFGRSVYSLKAGIDQDADNRLFAESFNIAQEGLAKRFRIAPWHFLYNPPGFRKACGDVHRFVEQYID
QLDLENSEDLDDKTYGFIKRVAQESASQQHLRDQLLNVLLAGRDTTACCLSWTFRLLVRHEQVMIRLREEIASVMGDSAH
PTKEQIRKMPYLSCVIKESLRLYPPVPLNNREAIRTTILPTGGGPDADRPILVRKGELVVFSQYVNSRKKNIYGPDADCF
RPERWETGELDHIGWAYFPFNGGPRQCLGEDFALMEVSYTVVRLLQTFSSIILPKGEPIEPVGSERQRLTLVLSSADGCR
VQIHSY*
>CYP52J2 Uncinocarpus reesii
71% to 52J1 in overlapping parts
UREG_00942.1
MATFLLIQYVACIVFAYVGYCAIVRFREYCSDTAFGRRLGCQLPPELTKRLPFGIDRIKDLWETDSKGKLLAYLCDVAEQ
YEPGNNLTQYLLVGPRAFHVLHPANLEAVLSTNFSDYGFGARRAIFAPLLGNGISTQEGHAWRHSRELLRKQFIRVQYQN
LDHFREHVDNLIACLPKDGVIDLQPLFFNLTLDVATHLLFGRSVYSLRAGIDQDSKNKVFAESFNVALKGLARRFRSAPF
HFLYNPSKFRKACANVHHFVEQYIDELDIEETEAKDDSSYMFFRQVARESATKEDLRDQLLNVLFAGRDTAACCLSWTLR
LLIRHPYEMERLRAEVASVMRESSHPTRQQIRKMPFLACVIKESLRLYPPVPLNNREAVRTTVLPTGGGSDGQSPILVRK
GELVVFSQYVNSRKKNIWGPDAYEFHPGRWEENKLSDIGWAYFPFSGGPRRCLGEDFALMEVSYTLVRLLQTFPSIVLPD
DEPVEPVGSERQRLTLVLSSANGCRAHVQSA
>CYP52K1 Aspergillus oryzae
GenEMBL BAE66393.1
44% to 52A5, 44%
TO CYP52J1
MLTLSFSALLGIALAWAIHRLAWKYSRLKAICVKRDNKLATQYGCEQPPRLRNWWPLGIDRLIQIWTADS
EQRLMDLFTFPFKDVGYTLEQKFLGTIAFGTIDPENLEAIMTNIN
(0)
VFSFGLRRHILFPLLGDGIFTQEGK
SWRHSRELLRPQFTRQHYRDLNIFRPHVDR
LLHYLTGNGAATDLQPLFFRLTLDTTTEYLFGKSVNSLMP
GEATKGQSFANHFDMAQNYVVQRFRLLDLYWLIGGPKFWRSCSAVHRFIDEIIDTRMDSKEKDKDCNSKS
IFFDAVARDSRTRRDLRDQLTNVLLAGRDTTACLLSWTFHCLARHPDVLGRLNVEIASVVGTNTDLTRDD
FKRMPYLDQVLREVLRLYPPVPVNTRTAHKTTILPT
GGGKDGTKPFMVREGENVAFCVYAMHRREDLYGP
DAGQFRPERWDEDLPLFQNERTATWGYLPFNGGPRACLG
QDFGFVEAAYTVVRILQKYPIVKPDMYKGDI
QGRKWLGWSSHQPEGIEMVTEERQKMTIVLSLGDGCRVTLGR
>CYP52K1P Aspergillus flavus
97% to CYP52K1 Aspergillus oryzae
small 6 aa deletion and frameshift = &
AFL2G_11704
MLTLSFSALLGIALAWAIHRLAWKYSRLK (0)
AICVKRDNKLATQYGCEQPPRLRNWWPLGIDRLIQIWTADSEQRLMDLFTFPFKDV
GYTLEQKFLGTIAFGTIDPENLEAIMTNIN (0)
VFSFGLRRHILFPLLGDGIFTQEGK
SWRHSRELLRPQFTRQHYRDLNIFRPHVDR
LLHYLTGNGAATDLQPLFFRLTL
DTTTEYLFGKSVNSLMPGEATKGQSFANHFDMAQNYVVQRFRLLDLYWLIGGPKFWRSCSAVHRFIDEIIDARMDSTEKD
KDCNSKYIFFDAVARDSRTRRDLRDQLTNVLLAGRDTTACLLSWTFHCLARHPDVLGRLNVEIASVVGTNTDLTRDDFKR
MPYLDQVLRE
VLRLYPPVPVNTRTAHKTTILPT
GGAKDGTKPFMVREGENVAFCVYAMHRREDLYGPDAGQFRPERWDEDLPLFQNERTATWGYLPFNGGPRACLG
(1)
QDFGFVEAAYT &
KYPNVKPDMYKGDIQGRKWLGWSSHQPEGIEMVTEEGQKMTIVLSLGDGCRVTLGR
>CYP52L1 Graphium sp. ATCC 58400 AY438638.1
MMDPFYLLGGCCVFGIVYKSVATLYVNYVHGKTARELGCKPLPK
ERTRFFGLDILRREMKADREMYLPSDIMTRFEEVGATTYEYQMLNEKHIATCDPLVIQ
TVLATQFKEFTFGNRPWGTVLGNGIFSIDNIGDNKEWLHTRAMLKPQFLRNQVSDLEL
EEGHVRNFMSVLKVGDDGWTPKVNLQHMFFNFTLDSATEFLFGKSADCQLLFAPGGDP
KGVSKPLRAFLKALDVAKETVNTKWFLGNNGWIADSPTFRKNCAYVNDFMDALIAKTK
AELEAKPKGSKPSGGREKYHFLHAMLDETDDKVELRGQALNILLAGRETTASLLGWLW
YYLARHPIEFQKLRAAVLKDFGTAENPKPMSFESLKACDQLQYCNNEILRLFPLVSYN
SRMALTDTTLPRGGGPDGNSPIFVKKGQQIVYHPHAMHRRKDIWGQDADEFRPDRWKT
LRPGWEYIPFNGGGRICMGQQFALTEASYLTVRLLQRFDRIENLDPNPVLKQKFRIVN
TPGEGVLVRLHEAAAGA
>CYP52M1
Candida bombicola EU552419
alternative name Starmerella bombicola
MLIKDIILTPMSLSAVAGLLPLLFVAFLVLHEPIWLLWYRYAARRHKCSMPRFIEKSFPLGIQRTMDMIKTAKSYTLLEVQYDRVFNKFKARTYLXQAPLQYQIFTIEPENIKTILATKFNDFGLGARFHTVGKVFGQGIFTLSGNGWKQSRSMLRPQFTKDQVCRIDQISSHAAELIKEMNRAMKVDQFIDAQHYFHKLTLDTATEFLFGESCESLNPENQSCIVARDGSEITAEQFVESYNFLLNYAFKRTLSSKVYWLFNSKEFRDHKKRAQSYIDYYVDKALYATSFAAENSIAEKDAAAESSGIYVFSLEMAKVTRDPVTIRDQIFNILIAGRDTTAATLSFAIHFLARNPDVFNKLREEVLDHFGTKEEQRPLSFELLKQAPYLKQVINEVLRLAPVLPLNFRTAVRDTTLPIGGGPEQKDPIFVPKGTAVYYSIYMVHRDIKYWGPDAHEFNPNRWENLKLDNVWAFLPFNGGPRICLGQQFALTELSLTLVRLLQEYSKIEMGPDFPESPRFSTTLTAQHAPPGVVVRFS
>CYP52N1
Candida bombicola EU552421
alternative name Starmerella bombicola
MILYAVLGAFAAFLLYMDVLYPFVIYPLRARWHKCGYIPRDLSWPLGIPLTLVVLSKLRKDMLLQFMAAQDLSRPYKTSLRQFLGKWVIATRDPENIKAVLSTKFNDFSLKERGNRMRHVIGDGIFTQDGAPWKHSRDMLRPQFTKDQISRVELLSHHIDVLIREIRKSGGNVELQRLFHLMTMDTATHFLFGESVGSLEVSGESKGIEITDPKTGEIVNTVDFVESYTFANKFALKKIILNDLEFVADLTEPSYKWHLRRVHTVMDHYVQLALKATEKYDPDDDSEKGEYYFSHELAKLTRDPLSLRDQLFNILIAGRDTTAATLSYAFHYLTKNPAIYAKVREDVLTVFPNGDASLATYEDLRKAKYLQMVIKEVLRLAPAVPLNTRAAVRDTYLPRGGGPAGNLPVFVPKGTAVNYPTYILHRDPDIYGADAYEFNPERWRPENKLPNSPXYSWGYIPFNGGPRICIGQQFALTEIALTMIKLVLEFERLEPADDFEPNLQDKSSLTVMVGGSGVRVKLS
>CYP52P1 Aspergillus niger
gw1.4.1682.1|Aspni1
46% to CYP52K1
WPLGLDLLVQAFHYDRRQQILKFFLGVVAESGTTFEQNLLFSRGVDTIDPQNIQALLSTQYADFGLGLRPPTFCPLLGSG
IFTQDGAQWRHSRERLRPQFMTNRFTNFEQIRSAVDNLISSISDDNAVNLQPLFFRLTFETTLFLLFGQHLPSLQLEGIK
NQESDFANAFNLGQEYLAKRGRLGGFYWLLDGRDFREACKTCHEFVDRAVQKALDLTTKKTPGTKTEPYIFIDAFIEETR
NPEVLRDQCLNILLAGRDTTACCLTWTLRLLVQHPPVLSKLRAEISDTVGIGPRSPAPTIIQVKSLPYLSLVIKEVLRLY
PSVPVNSRAATKTTTLPTGGGPTGTAPILVRKGEAVGYCVYAMHRRRDIYGADADKFRPERWENDALKDVGWGYLPFNGG
PRVCLGREFALLEVGYTIMRLLQTFEVIEQAE
>CYP52P2 Mgr076 Mycosphaerella graminicola
53% to CYP52P1 A. niger, 47% to
52K1 (missing N-term)
yellow from JGI model e_gw1.8.895.1|Mycgr3
LGLGLLLRTFRVAKEQRLLHFFNDLVRSTGNW
TFEQRLLGISGIDTFEPENVEAVLSTQFEADFDLGERRKVFFALLGDGIFTQDGAAWARTRALLRPAFYQQNTDRMLDEIDGLVGKMLRDVPEGEEVDFQPLFFRLTLETTMSLLFGKRMEGEDEQRKKVEMDDFAAAFDEAQDWLARRGRLGGLYWLIDGPGFRKSCRIVHRFIDAAIEEALRVKDVNEGETEGYSVLGALLPETQDRKVLREQCLNVLLAGRDTTACLLSWTCRLLASHPRTLTTLRQEITQICGTDPSPPSRAQLKRMRYLDAILKEVLRLYSSVPINSRTASRTTTLPTGGGPDRTSPILIRKGQAVAYSPYIMHRREDIFGPDAADFRPERWLENDGRLFAEAGWAYLPFNGGRRVCLGQEFALLEAGSVIVGMVRRWREWKVAGDGEAFPEVGTERQKVTLVVSCAEGCRLEVKS*
>CYP52Q1 Aspergillus niger
e_gw1.11.186.1|Aspni1
45% to CYP52H3, 41% to CYP52P1
MPWSAASLSLATFFSALVALQLYWIVSRSYRSRKLSKQWNCEPVCRYPSGILGYKVVLRAKTAAQEGQVGSTIQGVHLQY
GNTLKVNLVGHDVVATCEPENIQAVLASQFSSFGLSEWRYPQYRPLLGRGIFTSDGTAWEHSRKLLRPQFTKNQIPSIEW
FDSHSENLMRSLPPDGHAFDIQPLAFRLALDSATGYLFGESINSLVKPDSNQTGVAETSGSGNEGFAAAFDYAQDILFRR
TLALSYYWLINPSDFRKSTRVVHKFVDYYVDKAIEYRSNIGNYKTGHEQKGEEYCFLHALAAETQDREFLRDQLVNVLLA
SRDDVASVLASTFYLLARDTRAWWKLKQEITDAVDRHASNITLKEIQSLPYLRGVLYEVLRLFPPVPVNARVAHHDTTIP
VGGGPDGRSPVFIPKGQMVAYSVWCLHRRRDLWGADAESFRPERWEGYNPPAWEFVPFNGGPRACLGQQFAMILISQQVF
RLVQHLDSIESAQPGPDMGLNPPLRQTLTMCHEHGVHLRVKRMRI*
>CYP52R1 Mgr006 Mycosphaerella graminicola
51% to CYP52G2 Aspergillus fumigatus
MHNVALLALLGLAVLGFYKIVASIALKWQHASKARQLGCQDPVVVPGGGVLGLKHLKNMMAADKAQRFPDFMLDRHEMMSKQTGRVCETFRTDLMGQSVFFTSDPENIKAILATQFQDFDLGPVRRAIMGKVLGDGIFIQDGKKWEHSRAMLRPNFVRDQVSDLDMEEIHVKNLLQVMPAKEAGWTDLVNIQTLFFRLTIDASTEFLFGESVLSQVAASKTDGKPNARDETIFSQNFDRSQYHMARQFRFADNYWLYRSSELDQNAKVVNEFVKTYVEAALAAPEKEKSDKYIFSEALAQQTRDPDEIRAQLLNILLAGRDTTASLLSWFFYEMLRNPAVFEKLRGVITETFGTFDEPTDITFATLKSCQYLQYCINETLRVWPVVPGNGRRSNKDTTLPRGGGPDGKSPIFIPAETGIDYSVHVLHRRKDIWGEDAGVFRPERFQGLRPNWTFIPFNAGPRICIGQQFALTEASYVIVRLLQKYDKIEAAPGELDAPALSNLSLTNCPAIPVTLRLHEAE
>CYP52R2 Mycosphaerella fijiensis
60% to CYP52R1 Mycosphaerella graminicola
fgenesh1_pm.C_scaffold_45000005
MQNYILIPLLGVALLTLYKILNIIVTRVQNASRSRQLGCQDPPMFPNCGFLGLKHVKLLQAADEKNMFPDFLEERQDIMN
KETGRVCSTFTSYQLGQTIYFTSDPENIKAILATQFADFDLGPIRHAIMGEVLGEGIFVQDGKPWEHSRAMLRPNFAREQ
ISDLDMEERHVQNLFAALPAQEDGWTAFTNIQQLFFRLTMDASTELLFGESVDSQISENPHITKNKSAAKRHDEAAFAIN
FDQAQLHMAKKFRLVNFHWLHNPKEYQVNNKVVNDFVKYYVDLALQQPSNEKQAEEGAHHGKEKFIFLEALAKETRDPDE
LRGQLLNILLAGRDTTASLLSWLFHLLLRNPHVFSTLRSTIITTFGPYHSPTAPITFSTLKSCQYLQSTLSEVLRLRTIV
PGNSRTANKPTTLPRGGGPDGTSPIFIPAGSPIDYSVHVMHRRKDLWGEDALEFKPERFSGRKSGWEFLPFNGGPRICLG
QQFALTEAGYVVVRVLQRFEGIEGIEGEEEEGAVQTDLGLTSCPKREVRLRLRVAREYV*
>CYP52S1 Yarrowia lipolytica
42% to 52H3, 44% to 52F1
CAG81974.1
MLLPLLFAGCVFFFLHQRLNYYRRKQRAYEKWLASGKFGAGQKVADIQVQNNFLRNPFGLVQFVEFLNRTKGAFFVDFVN
QNFQKYGYILPTRTLGKVNIITCDPELIKTVLATNFKDWSIGIRRKAMFPVLGNAIFSVEGDQWTHSRAMLRPQFARDSI
ANVADLERHVTRLINVFRGYGVQSFDCQKYFFQFTLDSASDFLFGESTNSLSVQDDKSESEDTGESFNVLTQQGENAESF
AQAFKVAFTFTAIRLRLQQFYWLLRPSNKKYRDSIDTVHRLVDGYVERALENKEDTDRYIISNQLVKVCDDKKYIRDQLL
GILLAGRNTTAAVLAWIMYESARRPEIWNKMRQEVTDTFSDGPVTSDELRKCVYVRSVINEALRVYPSVPMNQRVAVRDT
FLPTGGGPDGSLPLYCPRGTKVAYSVFALHMREDFYGSDSHIFRPERWNEGVGKGWQYLPFNGGPRICLGQQFALMEASY
TLVRLVQEFDTVELDMEVVDPPPKMSSFSMVHRDGVRIRVK
>CYP52T1 Aspergillus terreus
48% to CYP52G2
ATEG_03903.1
MNHPTVLAAILALIYVVYKCVDSISDRRKAKALGCQPVPVLKNRLPLGLDHAYRAFQAIKAGQMPDHQVQVYKEVGRRTF
AGSSLGASYIHTVEPKNIQAILATQFHDFELGDLRRKVFFPLLGNGIFTSDGKAWEHSRAMLRPQFTRGQVADLELEERH
VQELFRLMPTDQSGWTQQINLTPMFFRLTIDSATEFLFGVTVHSQRHTSSQQPATDTDAFPWKDLARHFDESTKHLGVRS
LFQELYFLYNPSSFRNNIKEIHRFADFCIQQGLQRLDQQKSSAAQRYIFLDELLKVTRDPVEVKSQLLNILIAGRDTTAG
LLSWTFWLLAQHPAVYSKLRARVLEDFGPDAGRPDRITFAALKACTYLQHVMSEVLRLFPAVPLNARRAARDTTLPLGGG
PDGKAPVFVKKGHEVGYSVYVTHRLEEYWGPDAARFNPDRWVDRKHGWDYLPFNGGPRICLGQQFALTEAGYVIVRLLQR
FDQVELAEPATAPSHNYGITDAPHDYMIYLHEAGSKGG*
>CYP53A1
Aspergillus niger X52521
MLALLLSPYGAYLGLALLVLYYLLPYLKRAHLRDIPAPGLAAFT
NFWLLLQTRRGHRFVVVDNAHKKYGKLVRIAPRHTSIADDGAIQAVYGHGNGFLKSDF
YDAFVSIHRGLFNTRDRAEHTRKRKTVSHTFSMKSIGQFEQYIHGNIELFVKQWNRMA
DTQRNPKTGFASLDALNWFNYLAFDIIGDLAFGAPFGMLDKGKDFAEMRKTPDSPPSY
VQAVEVLNRRGEVSATLGCYPALKPFAKYLPDSFFRDGIQAVEDLAGIAVARVNERLR
PEVMANNTRVDLLARLMEGKDSNGEKLGRAELTAEALTQLIAGSDTTSNTSCAILYWC
MRTPGVIEKLHKALDEAIPQDVDVPTHAMVKDIPYLQWVIWETMRIHSTSAMGLPREI
PAGNPPVTISGHTFYPGDVVSVPSYTIHRSKEIWGPDAEQFVPERWDPARLTPRQKAA
FIPFSTGPRACVGRNVAEMELLVICGTVFRLFEFEMQQEGPMETREGFLRKPLGLQVG
MKRRQPGSA
>CYP53A2 Aspergillus parasiticus
GenEMBL AC005991
Lewis,J., Kupfer,D., Keller,N. and Roe,B.A.
Aspergillus parasiticus Cosmid Clone ap0
Unpublished
57% to CYP53A3
27896 MLLDLYLVKCLFCPL
27941
VPIVALGLLVAYYVAGYLKQWHLHDLPGPFIAGFSRIWLILQVRQGYRSLVVNDLHRRCG 28120
28121 KIVRLAPNHISVADESAIQAIYGHGNGFLK 28210
intron
28267
SNFYNAFLNVDWSIFTTRSRAEHTRKRKIVSHAFSARSLAQVEQYAHNTMELLVRQWQ 28440
28441 KMVDSQEGLDDPYAVIDARVWCNYLTFDIIGDLAFGAPFGMLERGNAIVSMRKALEDAAV
28620
28621
TLDAVEVLNHRGDVSAALGICPDLIPYAKWLPDLFFRQGAEAIANVADVAGAAVDRRLKM 28800
28801
NTSMTEKRGDLLAHLIDAEDQAGAKLGYRELTGEAVTLIAAGSDTSSSTLCALLYWVSTT 28980
28981 PRVLWKLQNVLDEVIPVDVEVPYLAMVKKI 29070
intron
29117 PSLQWVIWEALRIHSTFGQGLPREVPPERGPVEICSHTFYPGDVLSVPGYTMHHSVDIWG
29296
29297
IDVEDFVPERWDPCRLTQRQKDSFIPFSEGPRACIGRNLAEMEFFVGCATLFRLFEFRVE 29476
29477 GQGPLEVREGWLRKPVSLQVGIRRRYLDVRSS* 29575
>CYP53A3 Aspergillus nidulans AN7589.1 64%
to 53A4 53 clan
MITDFLTPE
NITPERIALALLGLLAAYYVVPYLQTWRLSDIPAPGLAAWTNFWLLLQTR
LGHRFISVDNAHKKYGKLVRIAPRHISIADDAAIQAVYGHGNGFLKSDFY
DAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSAKSIGQFEQYIHHNIENLV
KQLTRISNLQRNPKNGYATVDALNWFNFVAFDIIGDLAFGAPFGMLDKGQ
DIAEMRKSPDSPPQYVQAVEVLNRRGEVSATLGCYPALKPFAKYLPDRFF
RDGLEAVENLAGIAIACVNERLKPEVMANNTRVDLLARLMEGKDANGNKL
GRAELTAEALTQLIAGSDTTSNTSCAILYYCLRTPGVIDKLHKVLDEAIP
QDVEVPTHAMVKEIPYLQWVIWETMRIHSTSAMGLPREIPEGNPPVEISG
HIFKPGDILSVPTYTIHHSKEIWGADADEFIPERWAPERLTARQKAAFIP
FSTGPRACVGRNVAEMELLVICSTVFRMFDWELQQKGPMETREGFLRKPL
GLTVGVKRRTIV*
>CYP53A4 N.
crassa AABX01000266.1 cont3.41 NCU01086.1 (version3)
243627
MAIISLLMSPWAPVVLLAGVAFYYLVPYFVTYSALRK
IPSPFPAQFTDLWLLSVCRRGNRYQRVDELHKKLGPVVRIQPNH
VSICDDAAIPTIYGHGNGFLN
(2) 243932
243994
DFYDAFVSIRRGLFNTRDRAEHT
RKRKIVSHTFSAKSVQQFEPYMHSNLELFVKQWDSMIKNSKNPDKAAHLD
CLEWFNYLAFDVIGDLSFGQPFGMLSSGADMAEIRSSPDAAPIYAPAIEI
LNRRGEVSATLGIHPALKPFAKYLPDPFFTKGLAAVENLAGIAIACVKSR
LDNPPPVTRKDLLQRLMEGRDEKGEPLGREELTAEALTQLIAGSDTTSNS
SCALLFHAVRTPGVMQKLQAELDANIPPEVDVPTYDMVKELPYLEAVINE
VLRFHSTSGIGLPRQIPHDASQGVHIQGYYLPPGTVLSVPTYSIHHSKEI
WGPDADEFKPERWERLTARQKNAFIPFSHGPRSCVGRNVAEMEMKLIVAT
WARRYEVKLLQDYMDTREGFLRKPLGLKVGLKLRK*
245220
>CYP53A5 Magnaporthe grisea MG07977.4 69% to CYP53A4 (split on two contigs)
AACU01000984.1 cont2.1481 runs off end,
changed C-term
AACU01000983 cont2.1480 = N-term
89
MAIVNLVFTPLGLASLGAFMLVAYYVVPYFTTFGHLRSIQPASPLAGFSNLWLLYTSRVG 268
269
KRSLLVDEAHARLGPVLRVQPNHVSIADDEAINIIYGHGNGFLKSSFYDAFVSIRRGLFN 448
449
TRDRAEHTRKRKLISHTFAPKSVGQFEPYIHGNLELFAKKWDELIERTKKSDGWAPVECL 628
629 QWF 634
XXXXXXXXXXXX
2
FGAPFGMLNAGADIAEVRMSVDSEPIYAPAVEILNRRGEVSATLGTLPELKPYAGY
LPDSFFSKGLAAVQNLAGIAIARVKSRLENPPDVNRKDLLARLQEGRDAK
GEPLGFEELTAEALTQLIAGSDTTSNSSCALLYWTARTPGVLAKLQAELD
AAIPDGVFAPAFDMIRNLPYLEAVINETLRIHSTSGIGLPRQIPADSPGV
TIRGQYYPPGTVLSVPTYTIHHSKEIWGPDADEFRPERWIENGGLTDRQK
NAFIPFSYGPRACVGRNVAEMEMKMIAATWARRYDVEVRQDVME
VREGFLRKPLALEIGLKRRS*
>CYP53A6 Fusarium graminearum FG08079.1
AACM01000324 FGcontig1.324_scaffold5
MAMFTVLPLIWLAPLGLISLFFYYIIPYFWNYRHLRSIPGPLFARLSNWW
LVYACREKSRWKYVNDAHTRYGPVVRIQPNHVSIANEEVINAIYGHGNGM
LKSSFYDASVITTYSIFTSRDRAEHSRKRKVVSHSFAPQSMRNFEPFIQQ
HLNVFLQKWDAMAANEAKFDGYADVESRVWLNYLVLDIIGDLAFGAPFGV
LAKGSEVVDFETEKGPSSLPVITSLSTRSEIAATVGALPELKPYLKWSPD
PFFRTGFNGMINLRTLGTSRITDRLNNPPGDEREKDLLERVREGRDHKGQ
PFGKGELIAEALTVLIAGTDTTSSTMAALLYHVVRTPGVLKKLQAELDEA
IPADVSIPSFEMVKNLKYLGFVVNEALRHHSTISLGLPRLVPENGNGVTI
AGYHFAPGTVLSIPIYTVHHLKEVWGPDADEFKPERWEDVTQRQKQAFIP
FSHGPRACLGRNLAEMELKVITATWARRYDLIMRDDTMEILEGLARKPEA
VNVGIRRRM*
>CYP53A7 Fusarium graminearum FG08086.1
AACM01000324 FGcontig1.324_scaffold5
MAITELLVSPW
APVALVVAFVAWYILPWVSNKDLRGIPAPFPAQFSNLWLLSTCRRGKRYE
IVDQVHKKLGPLVRIAPNHVSVADADAINTIYGHGNGFLKADFYDTFVSI
RRGLFNTRDRAEHSRKRKIVSHTFAPKSVLEFEPYIRQNLEIFVKQWDRI
SSNKERDGYGRVDCLNWFNFLAFDIIADLAFGKPFGMLASGADIAEVKAS
PTSPTIYAPAVEIMNRRGEVSATLGCLPQLKPYAKYLPDPFFSQGLQAVE
NLAGIAIARVSERLERGGDSTRKDLLARLMQGRDEKGEPLGRDELTAEAL
TQLIAGSDTTSNSSCALLYHIVRTPGVMKKVYEEISAVMPDGVDIPDFES
VKHLPYLGYCINETLRIHSPSGIGLPREVPPNHKGVTIHGRYFGPGTVLS
VPTYTIHHSTEIWGPDADDFKPERWETLTDKQKSAFIPFSYGPRSCVGRN
LAEMQMRMIAATWIKRYDVVLRQDVMETREGFLRKPMGLDVGLARR*
>CYP53A8 Fusarium graminearum FG10451.1
AACM01000435 FGcontig1.435_scaffold7
MAIVDLLFTWWSLPIAAGLVAASYLYSYFITYGHLRDIPAPFPAQFSNLW
LLYVCRRGERYRVVDQIHKELGPVVRIQPNHTSIADAEAIATIYGHGNGF
LKSEFYDAFVSIRRGLFNTRDRAEHTRKRKLISHVFSAKSISQFEPYIHA
NLELFVKQLDKLVASGQMAKNGKREALMDCLPWFNYLAFDVIGDLAFGVP
FGMLASGADVAEVRDTPDSPPIYASAIEILNRRGEVSATLGCFPQLKPYA
QYLPDPFFSNGLNAVKNLAGIAIARVKNRLDNPPSIERMDLLARLMEGRD
EKGEPLGREELTAEALTQLIAGSDTTSNSSCALLYHVTRTPGVLEKLQSE
LDNAIPSEVSVPTYDMVRDLPYLANVINETLRYHSTSGIGLPRQIPPNSP
GVTIKDHFFPPGSILSVPTYTLHHSKEIWGADADDFRPERWENPTELQKT
AFNPFSHGPRACVGRNVAEMEMKLIAATWARRYVPELRQGVMETREGFLR
KPLGLDIALMMRE*
>CYP53A10 Nectria haematococca fgenesh1_pg.scaffold_37000003
Necha1/scaffold_37:6771-8451
59% to fgenesh1_pg.scaffold_12000228,
83% to Fusarium graminearum CYP53A7
FG08086.1 AACM01000324 FGcontig1.324_scaffold5
Note: this seq has two more introns than the
CYP53A8 ortholog
This gene model seems correct DRN 2/4/06
MALINLLISPWAPVALVVLFVGWYLVPYFGANRGLRGIPAPFPAQFSNLWLMSTCRRGKRFEVVDQVHKR
LGTVVRIAPNHVSIADADAINVIYGHGNGFLKS (2)
DFYDPFVSIRRGLFNTRSRAEHSRKRKIVSHTFAPKSVLEFEPYIHQNLDLFVKQWDRASSNPEADGAGRLDCLSW
(1)
FNYLAFDVIADLAFGKPF (1)
GMLATGADIAEVK
ASPTSPAIYAPAVEIMNRRGEVSATLGCMPWLKPYAKWLPDPFFSQGLQAVENLAGIAIARVSERLERGA
DTTRKDLLARLMQGRDEKGEPLGRDELTAEALTQLIAGSDTTSNSSCALLYHVVKTPGVLQKLQQEIDEA
TADEGVIPSYESVKHLPYLGMCINETLRHHSPSGIGLPREIPAKSKGVTLHGRYFGPGTVLSVPTYTVHH
STEIWGPDAEEFKPERWENITDKQKIAFIPFSHGPRSCVGRNLAEMQMRLIAATWIKRYNIFLRQEKMET
REGFLRKPLGVEIGVSRR*
>CYP53A11 Nectria haematococca fgenesh1_pg.scaffold_12000228
Necha1/scaffold_12:587439-589032
84% to Fusarium graminearum CYP53A8
FG10451.1 AACM01000435 FGcontig1.435_scaffold7
64% TO 53A1 Aspergillus niger
This gene model seems correct DRN 2/4/06
MAIVDLLLSWWTLPIGVAVLVGTYLYAYFVTYGYLRGIPAPFPAQFSNLWLLYVCRRGERYDVMDKIHKK
MGPVVRIQPNHVSIADDEAIPIIYGHGNGFLKS (2)
EFYDAFVSIRRGLFNTRDRAEHTRKRKLISHTFSTKS
ISQFEPYIHSNLELFVKQLDKLITSGTTKDNQGHQQALIDCLPWFNYLAFDVIGDLAFGAPFGMLANGAD
VAEVRATPESPPIYASAIEILNRRGEVSATLGCFPQLKPYAKWLPDPFFSNGLNAVQNLAGIAIARVKAR
LDNPPPEERMDLLARLMEGRDEKGEPLGREELTAEALTQLIAGSDTTSNSSCALLYHVTRTPGVLEKLQA
ELDASIPSHVSVPTFDMVRDLPYLNCVINETLRYHSTSGIGLPRQVPEGSPGVTIRGHFFPAGSVLSVPT
YSIHHSKEIWGPDADDFKPERWEDVTPRQKNAFIPFSHGPRACVGRNVAEMEMKLIAATWARRYNVELKQ
EIMETREGFLRKPLGLDIALKIR*
>CYP53A12 Aspergillus fumigatus Af293
EAL93820 XP_755858 cytochrome P450 benzoate 4-monooxygenase
join(<2165575..2165876,2165928..2166734,
2166796..>2167246)
85% to CYP53A1
MITDLLSLQNAGLILLGLIAVYYVIPYLQKWHLHDIPSPRFAAFSNLWLLLQARRGRRFLKVDEAHKKYG
KLVRIAPKHVSIADDAAIQAIYGHGNGFLKADFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSMKSIG
QFEQYIHQNVELFVQQWTKLAKLNGNPRSGYATIDALNWFNYLAFDIIGDLAFGAPFGMLEKGKDIAEMR
KTPDSEPTYVQAVEVLNRRGEVSATLGCLPRLIPYAKYLPDRFFKDGVQAVENLAGIAVARVNERLKPEV
MEKNTRVDLLSRLMEGKDSNGNKLGREELTAEALTQLIAGSDTTSNTTCAILYWCMSTPGVIPKLQKVLD
EAIPDDVDVPTHAMVKDIPYLQWVIWETMRIHSTSAMGLPREIPPGNPPVTISGHTFYPGDVVSVPSYTI
HRSKEIWGPDAEKFVPERWDPARLTARQKAAFIPFSTGPRACVGRNVAEMELLVMTGTIFRLFEFEMQQD
GPMETREGFLRKPLGLIVGMKRRAVHASV
>CYP53A12 Neosartorya fischeri
96% to CYP53A12 Aspergillus fumigatus =
ortholog
NFIA_090480
MITDLLTPQNTGFILLGLIAAYYIVPYLQKWHLHDIPSPSFAAFSNLWLLLQARRGRRFLKVDEAHKKYGKLVRIAPRQV
SIADDAAIQAIYGHGNGFLKSDFYDAFVSIRRGLFNTRDREEHTRKRKTVSHTFSMKSIGQFEQYIHQNVELFVQQWTKL
AKLNGNPRSGYATIDALNWFNYLAFDIIGDLAFGAPFGMLEKSKDIAEMRKAPDSDPTYVQAVEVLNRRGEVSATLGCLP
RLIPYAKYLPDRFFKDGIQAVENLAGIAVARVNERLKPEVMEKNTRVDLLSRLMEGKDSNGNKLGREELTAEALTQLIAG
SDTTSNTTCAILYWCMSTPGVIPKLQKVLDEAIPDDVDVPTHAMVKDIPYLQWVIWETMRIHSTSAMGLPREIPPGNPPV
TISGHTFYPGDVVSVPSYTIHRSKEIWGPDAEEFVPERWDPARLTARQKAAFIPFSTGPRACVGRNVAEMELLVMTGTIF
RLFEFEMQQDGPMETREGFLRKPLGLIVGMKRRAVHASV*
>CYP53A13 Aspergillus oryzae
GenEMBL
BAE60506.1
58% TO
CYP53A14, 81% to 53A3
MIAELLTPTGAAYVLTAAVIVYYILPYLQLWRLRDIPSPGFAAFSNLWLMLQYRKGNRFVTVDNAHKKYG
KLVRIAPRHVSIADDEAIQAIYGHGNGFLKADFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSMKSIG
QFEQYIHGNAELFVKQWNRIADTQSNPKTGYATIDALNWFNYLAFDIIGDLAFGAPFGMLEKGQDIAEMR
KSPNDKPSYVQAVEVLNRRGEVSATLGACPSLIPWAKYIPDRFFRDGLEAVENLAGIAVARVNERLRPEV
MANNTRVDLLARLMEGKDSNGNKLGREELTAEALTQLIAGSDTTSNTSCAILYWCLRTPGVIEKLHKVLD
ESIPKDVDVPVHAMVKDIPYLQWVIWETMRIHSTSAMGLPREIPAGNPPVTISGHTFYPGDVVSVPTYTI
HRSKEIWGPDAEQFVPERWDPKRLTARQKAAFIPFSTGPRACVGRNVAEMELLVIVGTVFRLFDFEIQQD
GPMETREGFLRKPLGLMVGMKRRSVAV
>CYP53A13 Aspergillus flavus
99% to CYP53A13 Aspergillus oryzae, 1 aa diff, N-term extension deleted
AFL2G_03223
MIAELLTPTGAAYVLTAAVFVYY
ILPYLQLWRLRDIPSPGFAAFSNLWLMLQYRKGNRFVTVDNAHKKYGKLVRIAPRHVSIADDEAIQAIYGHGNGFLKADF
YDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSMKSIGQFEQYIHGNAELFVKQWNRIADTQSNPKTGYATIDALNWFNYL
AFDIIGDLAFGAPFGMLEKGQDIAEMRKSPNDKPSYVQAVEVLNRRGEVSATLGACPSLIPWAKYIPDRFFRDGLEAVEN
LAGIAVARVNERLRPEVMANNTRVDLLARLMEGKDSNGNKLGREELTAEALTQLIAGSDTTSNTSCAILYWCLRTPGVIE
KLHKVLDESIPKDVDVPVHAMVKDIPYLQWVIWETMRIHSTSAMGLPREIPAGNPPVTISGHTFYPGDVVSVPTYTIHRS
KEIWGPDAEQFVPERWDPKRLTARQKAAFIPFSTGPRACVGRNVAEMELLVIVGTVFRLFDFEIQQDGPMETREGFLRKP
LGLMVGMKRRSVAV*
>CYP53A14 Aspergillus oryzae
BAE56637.1
56% to 53A3
MDGDSCPSCCSTCTSLNVFLCPHIPILTLGLLLVYYVTGYLKRWHLRDIPGPFIAGFSRIWLIVQVRQGY
RSLVVHDLHRRYGKIVRLAPNHISIADESAIQAIYGHGNGFLETDFYNAFLNVDWSIFTTRSRAEHTRKR
KIVSHAFSARSLAQVEQHAHNNMEHLVRQWRKMIDSEEGLDDPYAVIDARVWCNYLTFDIIGDLAFGAPF
GMLERENATVSMRKAPENPEVTLDAVEVLNHRGDVSAAFGICPDLIPYAKWLPDPFFRQGAEAIANLAGV
AGAAVDRRLKMDTSMTEKRGDLLALLIDAEDQAGAKLGHRELTGEAVTLIAAGSDTSSSTLCALLYWVSS
TPRVLWKLQNVLDEVIPVDIEVPYLAMVKKITYLQWVIWEALRIHSTFGQGLPREVPPERGPVEICGHTF
YPGDVLSVPGYTMHHSADIWGIDVEDFVPERWDPRRLTQRQKDSFIPFSEGPRACIGRNLAEMELFVGCA
TLFRLFEFRVEGQGPLKVRERWLRKPVSLQVGIRRRYLDARSS
>CYP53A15 Cochliobolus lunatus Nada Krasevec
EU597483
65% to
CYP53A1
MFLTSLLLTPYTILLLPVLFYLLPYLRNWRIRDIPAPFPAAWTNLWLLYQCRRGRRFLAVHEAHQKLGKLVRIQPNHVSIADADAITQVYGHGNGFLKSEYYDAFVSIRRGLFNTRDRAEHTRKRKTVAHTFSAKSVLQFEQYIHHNLQELQNQWDRRAESVKGGWYEMDALNWFNYLAFDVIGDLAFGEPFGMLKKGRDEAEVARGGKITYAPAIEVLNRRGEVSGTVGIFPAIKPYAKYFPDPFFSQGMKAVENLAGIAIARVNARLEKPSDRVDLLARLMEGRDENGNKLGREELTAEALTQLIAGSDTTSNTSCALLYHCLQHPEVVQKLQNELDAALPNPDAVPSYAQVKDLPYVDAVIKETMRIHSTSSLGLPRVIPPGPGVTILGRHFPQGTVLSVPAYTIHHSTEIWGPDADTFRPERWEKVTEQQKAAFIPFSYGPRACVGRNVAEMELALIVATVFRRYEFELRQGEMETREGFLRKPLALQVGMRKRSFA
>CYP53A16 Mgr055 Mycosphaerella graminicola
64% to CYP53A11 Nectria haematococca
MFLSVLFTPWALVVLPVLYFVLPFLRNWSIMDVPGPFLAKFTTLWYMYECRRCRRYLTVHKLHEKYGKFIRVQPNHVSIADPEAIPIVYGHGTGTLKSEYYDAFVSIQRGLFNTRNRAEHTRKRKTVSHTFSAKSVGQFEQYIHHNLELLAKRWDELSEKSSGGYARFDALHWFNYVAFDIIGDLAFGAPFGMLERGADMAEVQLTPDGPPTYAPAIEVLNRRGEVSNAVGCWPQIKPYAKYLPDPFFSKGMAAIANLAGIATARVNARLAAAEKGEINRVDLLARLMEGKDENGEKLGRAELTAEALTQLIAGSDTTSNTSCALLYHCLTKPNVVKKLQAELDEALPSNDVPTFDQVKDLKYLDMVIQETLRIHSTSSQGLPRQIPAGDGLDVAGRHFPQGTVLSVPAYVMHHSKEIWGPDADEFRPERWEKVTERQKSAFIPFSYGPRACVGRNVAEMELALIVSTVFRRYEFELHQDELETREGFLRKPLGLEVGMRKRDH
>CYP53A17 Uncinocarpus reesii
74% to CYP53A1 Aspergillus niger
model has some missing seq (added back)
UREG_05168.1
MLLAFLFNPYIIAGFTICYFYIVPYLQRWDLRDIPAPFPASLSHLWLLYQSRKGKRYQAVHNAHGKYGKLVRIQPNHVSV
ADADAIQTIYGHGNGFLKSEYYDAFVSIRRGLFNTRNRAEHTRKRKTVSHTFSAKSIGQFEQYIHANLQLFLQQWTQICD
LQRNPRSGYASIDALNWFNYLAFDIIGDLAFGAPFGMLSKGRDVAEMKKSPNSPASYVPAIQVLNRRGEVSATLGCFPAL
KPFAKYLPDRFFRDGLEAVENLAGIAVARVAERLRPEVMAKNTRVDLLSRLMEGRDETGAKLGREELTAEALTQLIAGSD
TTSNTSCAMLYWVLRTPGVIEKLQEVLDEAIPAHVEVPTFSMVKDIPY
(2)
LQWVILETMRIHS
TSSLGLPREIPQGSPPVTIQGHVFHPGTILSV
PAYTIHHSSEIWGPDVEEFVPTRWDPARLTAQQKAAFIPFSHGPRACVGRNVAEMELHCIAATVFKNFEFQLEQNGPMET
SEGFLRKPLGLLVGIKRRQLDPVVN
>CYP53A18 Coccidioides immitis
90% to CYP53A17
CIMG_09108.2
MLLSFLFNPYVLAGIFIFVFYIVPYLRLSYLRDIPSPFAAGFSNLWLLYQCRRGKRYQAVHDAHKKYGKLVRIQPDHVSV
ADADAIQTIYGHGNGFLKSEYYDAFVSIRRGLFNTRSRAEHTRKRKTVSHTFSAKSVGQFEQYIHANLQLFFQQWTNISE
VQRNPKSGYASIDALNWFNYLAFDIIGDLAFGAPFGMLSKGRDVAEMRKSPDSPASYVPAIQVLNRRGEVSATLGCFPAL
KPFAKYLPDKFFRDGLEAVEHLAGIAVARVSERLRPEVMAKNTRVDLLSRLMEGRDETGAKLGREELTAEALTQLIAGSD
TTSNTSCAMLYWVLRTPGVIEKLQEALDEAVPAHVNVPSFSMVRDIPYLQWVIWETMRIHSTSSLGLPREIPPNSPPVTI
EGHVFHPGTILSVPAYTIHHSPEIWGPDVEEFVPTRWDPARLTPRQKAAFIPFSYGPRACVGRNVAEMELHCIAATVFKN
FEFRLEQDGPMETSEGFLRKPLGLMVGIRRRQPNLN
>CYP53A19 Fusarium oxysporum
90% to CYP53A8
FOXG_04952
MAVVDILFTWWSIPIAACVLIATYLYSYFVTYGHLRDIPAPFPAQFTNLWLLYVCRRGGRYRVVDEIHKRLGPVVRIQPN
HTSIADPDAIATIYGHGNGFLKSDFYDAFVSIRRGLFNTRDRAEHTRKRKLISHVFSAKSISQFEPYIHANLELFVKQLD
KLVASGQTTDKNGKRQALIDCLPWFNYLAFDVIGDLAFGVPFGMLANGADVAEVRETPDSAPIYASAIEILNRRGEVSAT
LGCWPQLKPYAQWLPDPFFSNGLNAVKNLAGIAIARVKARLDNPPSVERKDLLARLMEGRDEKGEPLGREELTAEALTQL
IAGSDTTSNSSCALLYHVTRTPGVLEKLQAELDEAIPADVSVPTYDMVRDLTYLNNVISETLRYHSTSGIGLPRQIPDNS
PGVTIKGHYFPPGSVLSVPTYTLHHSKEIWGSDADDFKPERWDSVNNLQKTAFNPFSHGPRACVGRNVAEMEMKLIAATW
ARRYTPELKQEVMETREGFLRKPLGLDIALKMR*
>CYP53A19 Fusarium verticillioides
98% to CYP53A19 Fusarium
oxysporum = ortholog
FVEG_03183
MAVVDILFTWWSIPIATGVLIATYLYSYFVTYGHLRDIPAPFPAQFTNLW
LLYVCRRGERYRVVDGIHKRLGPVVRIQPNHTSIADPDAIATIYGHGNGF
LKSDFYDAFVSIRRGLFNTRDRAEHTRKRKLISHVFSAKSISQFEPYIHA
NLELFVKQLDKLVASGQTTDKNGKRQALIDCLPWFNYLAFDVIGDLAFGV
PFGMLANGADVAEVRATPDSAPIYASAIEILNRRGEVSATLGCWPQLKPY
AQWLPDPFFSNGLNAVKNLAGIAIARVKARLDNPPSVERKDLLARLMEGR
DEKGEPLGREELTAEALTQLIAGSDTTSNSSCALLYHVTRTPGVLEKLQA
ELDEAIPADVSVPTYDMVRDLTYLNNVISETLRYHSTSGIGLPRQIPDNS
PGVTIKGHYFPPGSVLSVPTYTLHHSKEIWGPDADDFKPERWDSLNELQK
TAFNPFSHGPRACVGRNVAEMEMKLIAATWARRYTPELKQEVMETREGFL
RKPLGLDIALKMR*
>CYP53A20 Fusarium oxysporum
92% to CYP53A7
FOXG_02776
MAITELLISPWAPLALAVALVAWYILPWISNSNLRGIPAPFPAQFTNLWLLSTCRRGKRYEIVDQVHKKLGVLVRIAPNH
VSVADADAINTIYGHGNGFLKA
DFYDTFVSIRRGLFNTRNR
AEHSRKRKLVSHTFAPKSVLEFEPYIRQNLDIFINQWDR
IASNKDADGYGSVDCLNW
FNFLAFDIIADLAFGKPFG
MLSTGADIAEVKASPTSPTIYAPAVEIMNRRGEVSATLGCLPQ
LKPYAKYFPDPFFSQGLQAVENLAGIAIARVSERLERGGDSTRKDLLARLMQGRDEKGEPLGRDELTAEALTQLIAGSDT
TSNSSCALLYHVVRTPGVMQKLYEEISAVVPEDVAIPDYESVKHLPYLGYCINETLRIHSPSGIGLPREIPPNHKGVTLH
GRYFGPGTILSVPTYTIHHSTEIWGPDADEFKPERWENLTDKQKTAFIPFSYGPRSCVGRNLAEMQMRLIATTWIKRYDV
RLRQDIMETREGFLRKPMGLDVGLARR*
>CYP53A20 Fusarium verticillioides
97% to CYP53A20 Fusarium
oxysporum = ortholog
FVEG_01611
MALTELLISPWAPLALAVALVAWYILPWISNSNLRGIPAPFLAQFSNLWLLSTCR
RGKRYEIVDQVHKKLGVLVRIAPNHVSVADADAINTIYGHGNGFL
KADFYDTFVSIRRGLFNTRDR
AEHSRKRKIVSHTFAPKSVLEFEPYIRQNLDIFINQWDRIASNKEADGYGSVDCLNW(1)
FNFLAFDIIADLAFGKPF (1)
GMLSTGADIAEVKVSPTSPTIYAPAVEIMNRRGEVSATLGC
LPQLKPYAKYLPDPFFSQGLQAVENLAGIAIARVSERLERGGDSTRKDLLARLMQ
GRDEKGEPLGRDELTAEALTQLIAGSDTTSNSSCALLYHVVRTPG
VMQKLYEEISAVVPEDVAIPDYESVKHLPYLGHCINETLRIHSPSGIGLPREIPPNH
KGVTLHGRYFGPGTVLSVPTYTIHHSTEIWGPDADEFKPERWE
SLTDKQKNAFIPFSYGPRSCVGRNLAEMQMRLIAATWIKRYDVRLRQDIMETREGFLRKPMGLDVGLARR*
>CYP53A21 Aspergillus clavatus
90% to CYP53A12
ACLA_074210
MITEILTPQNTGYVLLGLLTAYYIIPYLQTWHLHDIPSPGFAAFSNLWLLLQARQGHRFLKVDEAHKKHGKLVRIAPGHI
SIADDGAIQAVYGHGNGFLKADFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSTKSIGQFEQYIHHNIELFVKQWTKL
SKLNGNPRSGYATIDALNWFNFLAFDIIGDLAFGAPFGMLEKGKDFAEMRKTPDSPPTYVEAIEVLNRRGEVSAALGCFP
RLIPYAKWIPDRFFKDGLQAVENLAGIAVARVNERLKPEVMANNTRVDLLSRLMEGKDSNGNKLGREELTAEALTQLIAG
SDTTSNTACAILYWCMQTPGVITKLQKVLDEAIPADVDVPTHSMVKEIPYLQWVIWETMRIHSTSSMGLPREIPPGNPPV
TISGHVFYPGDVVSVPSYTIHRSREIWGPDAEQFVPERWDPARLTPRQKAAFIPFSTGPRACVGRNVAEMELLVMTATVF
RLFEFEMQQDGPMETREGFLRKPLGLIVGMKRRAAHASV*
>CYP53A22 Aspergillus terreus
85% to CYP53A12
ATEG_07877.1
MIADLAAINPAYLLLAAVAAYYIVPYLKRWHLRSIPTPSVAGFTNLWLLIQARRGNRFEVVDNLHKKHGKLVRLAPRHVS
IADDAAINAIYGHGNGFLKALSDFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSMKSIGQFEQYIHHNIELFVKQWTR
LSETQGNPRSGYATIDALNWFNFLAFDIIGDLAFGAPFGMLEKGQDIAEMRKSADAAPTYVQAVEVLNRRGEVSATLGTL
PALIPYAKYIPDRFFKDGIQAVENLAGIAIARVNERLRPEVMANNTRVDLLARLMEGKDANGNKLGREELTAEALTQLIA
GSDTTSNTACAILYWCMSTPGVIDKLHKVLDEAIPADVDVPTHSMVKDIPYLQWVIWETMRIHSTSAMGLPREIPAGSPP
INISGHVFYPGDVVSVPSYTIHRSREIWGPDAEKFVPERWDPARLTPRQKAAFIPFSTGPRACVGRNVAEMELLVMAGTV
FRLFDFEMQQKGPMETREGFLRKPLGLIVGMKRRTPA
>CYP53A23 Mycosphaerella fijiensis
88% to CYP53A16 Mgr055 Mycosphaerella graminicola
estExt_fgenesh1_pm.C_10348
MFLSFLFTPWALLASPFLFYLLPFLRNWSIRDVPGPFLAKFTTLWYMYECRRCRRYYTVYKLHEKYGKFVRVQPNHVSIA
EPEAIPIIYGHGTGFLKSEYYDAFVSIQRGLFNTRDRAEHTRKRKTVSHTFSAKSVGQFEQYIHHNLELLAKRWDEIAKN
TGAGKYTRFDALHWFNYVAFDIIGDLAFGAPFGMLEKGADIAEVQLNPDGPVTYAPAIEVLNRRGEVSNAVGCWPAIKPY
AKYLPDPFFSKGMEAIANLAGIATARVNQRLAAAERGEIDRVDLLARLMEGKDENGNKLAKAELTAEALTQLIAGSDTTS
NTSCALLFHCLKNPHVVKKLQAELDEALPSDDVPTYEQVKNLQYLDQVISETLRIHSTSSQGLPRVVPPGDGVEVAGRHF
PPGVVLSVPAYVMHHSKEIWGPDADEFRPERWEKVTERQKLAFIPFSYGPRACVGRNVAEMELALIVATVFRRYEFELYQ
DELETREGFLRKPLGLQVGMRKRS*
>CYP53B1
Rhodotorula minuta D63703
MGIVQEAAAFVGSLTAVQLAGAFAALVLAFHVVPYILDPHGLRK
YPAAGPFGIAAFTDAWVVWQARRGKRFEALDKAHRKYGKYVRISPRQVSIADPKALDT
IYGHGTGTMKPAFYDAFVGLKNVRGLFNTRDRAEHTRKRKIVSATFAQRNVLEFEPYI
ASVMRQLLNKWDAMCDKAVKDGKGWVTLDTLTWLNFLAFDIIGDLAFGAPFGMVEREA
DICEIEQEDGSIKHLPAVTILNERGEYSNCLGVMPPHWRPFSKYVDPWFSRGHASVIN
LAGMARARVNARLKSGAGDRKDLLARLQEARDESGNPMDIDELTAEALTQLIAGSDTT
SNSSCAIIFYLARNQDAQKKLQAELDKTFKDRGISGVMEYEDIKTLPYLEACINEALR
MHSTSSMGLPRVMPAQGADFQGEHFKEGTEVSVPAYTIHHLESIWGDPFNYRPERWLG
SDAKQLEKSFIPFSIGPRSCVGRNLATMELLVFMSTLFYRYDFKLADENQTKLETSEG
FLRKPLESWIKMRRRSIDA
>CYP53B2 Sporobolomyces roseus
57% to CYP53B1 Rhodotorula minuta, estExt_fgenesh1_pg.C_30339
MTQSHVFTDFFEPTTLAVYFLAAPLGAVFLYLFVPHFTSLAPLRRFPGPFWAGYTRLWLARTARVGKRSELVHREHLKHG
KFVRIGPNEVSIADPAALPIVYAHGSGSIKADFYDAFVASPVRGLFNTRNRAEHTRKRKIVSHTFAPKSVREFEPYIAST
VNLLLKKWDQLAAKAQKSPPSGTGGERMKGYAVIDSLDWFNALAFDVIGELAFGTPFGMVERDAADIVTITKEDGTVIHA
GGVQILNMRGEYSATLGCLPPWSRKYMKYIDPWFARGLESVKNLTGIARTRVNDRLEKGALDRKDILSHLQAGRDENGQP
MSKDELTMEALTQLIAGSDTTSNSSCAILFQIVSTPHAHKKLQQELDEAFSGKGMSGVLEYEDVKALPYLGACINEALRR
HSTSGIGLPRIMMDDTEVLGEVFPKGTVLSVPSYTIHWSTEFWGPDAAEFKPERWLESEEKTRQLEKQLNVFSFGPRSCV
GRNVAMIELFCFMATLVYRYDFKLVDPNQKELEVVEGFLRKPTGCQIGFKLRDATQ
>CYP53B3 Puccinia graminis f. sp. Tritici
54% to CYP53B2 from LNRYP
PGTG_08085 + PGTG_08086 revised
MLVIGLIAAFLEYSILLGLVGISCYYLTGYLRNKHQLNRYPGPFLAKFSRLWLGYATRFGNRYQIIHQLHQKHGRFVRIA
PNELSIADPDAVHIVLGHGTGTTKSKF (1)
YDAFVAIHRGLF (0)
NTRDRADHTRKRKIISSTFSQKSILEFEPYIADTLACFLRKIDQVASEP
NLVQLPSHSWDSKHLNERWRIIDILPWFNYLAFDIIGDLAFGERFGMIERGADIAAVEKEGKVIYLPAIQILNERGEFSA
TQGQFDHIKFSKKKKEKKK (0)
YIDPWFSRGAASVQNLTG (0)
IATNQV
NLRISQTGQSRRDLLARLQTGQDADGNPMGKDELIAEALTQLIAGSDTTSNSSCAILWWVVKHPEVHKRLMEELDE
HLGTEEGVISYADCKELKYLNACINETLRIHSTSSIGLPRILPQTVSFKGHILPKGLVCSVPTFEIHHDPDVWGDP
(2)
FTFRPERWLEPNAKDREKAFMPFS (2)
CGPRSCIGRNLAMMELY (0)
MITSTIFKRYEFALVDPDLAELETREGFLRKVGFSLQQKT*
>CYP53C1 Ustilago maydis
GenEMBL XM_397620.1
MVETDLVPRIGAAIQWSVESPAHVVITLLGAVVLFHVVPYITNT
ACIKYPGPFFAKFTDFWLLRTALIGHRFEEVHKQHQKYGKFVRIAPNHVSIADHEALQ
PIYGHGTGTLKPAYYDAFVPPRPFPRGLFNTRDRAEHTRKRKIVSHTFAPKTIVAFEP
FIRREVQLLLERWDEFCDKATKDNTEGPRGIKGRAWLDSLMWLNYFAFDTIGALAFGK
TFGMLENGVDQAKVEYEDANGNKQVDYCSAVQIINERGEFSGTMGLAPVWMRPYLIKL
PWFSSRLKSVKKLTGIALARVNDRLQNGSEREDLLAKLQAAKDDRGEPMGKMELTAEA
LTQLIAGSDTTSNTSCAIVYHLATHPDKMRKLQAELDRELEHAEEVPLHADVQELPYL
QAVLSESLRYHSTSAIGLPRVIPAGGATVCGQQFPSGTILSVPAYTLHRDKSVFGADA
EEYNPDRWLAPNAKRDFEKAFIPFSVGPRACVGRNVAMMELSILIAAIFRRYDIVLAE
PDKPLDTFEGFLRKPVKLEVGLKRRN
>CYP53C2 Phanerochaete chrysosporium
AY321584
55% to CYP53C1
my Scaffold_164a
MAVIEALTQLDLKSWLLLIPALAIVAHILVWLLDPHGIRSYPGP
LLAKFSDAWLGYVAAQGHRSEVVHDLHKQYGTFVRIAPNHLSIADPDALQVVYGHGTG
TLKSNFYDAFVSIQRGLFNTRSRSEHARKRKIVSHIFSQKSVLEFEPHVRLYVKQLIQ
QWDRLYEAGAKGLSGDDGEGGWRGRNGRVWLDCLPWYNYLAFDIIGDLAFGAPFGMLL
AARDAAPVAVDHEQAMASYGKEKSEVQYIPAVQVINDRGTYSASLGVLPPWMRPIVKL
FPWFRRGQKAVKQLAGIAVAAVAQRLTTPTDRVDLLGKLQEGRDDDGNLMGKEELTAE
ALTQLIAGSDTTSNSSCAITYYLAKYPDAQRKLQQELDEALGSDDEPVSTFDQVKRLP
YLQAVIDEALRIHSTSGIGLPRLVPKGGMTVCGRFFPEGTVLSVPTYTIHRDEEVWGK
DPEVFRPERWFEQDKNAVQKTYNPFSFGPRSCIGRNLANMELLIIVSSILRRYDFVLE
DPDKPFDTMEGFLRKPVECVVGIRRRTL
>CYP53D1 Fusarium oxysporum
48% to CYP53A10
FOXG_14732
MSLDSLLLSPWAPLAVLLCVLLFYILPYFYTYRHLRGIPGPLLARFSDLWLLYICRQSKRSYT
VYDLHERLGPVVRIQPNHVSIVDERAINLVYGHGNGLEKS (2)
SWYDSSISLTRSIFTARKRAEHARKRRYIAHSFAPKSSRAAEGPIADKVELLVRKWDEIIDKGPQFD
GFTQLECRRWFTYLSFDITGDLLFSEPFGMLENGSDLVKIDNKPRSYVSMMNSLAQRSAAVATLGVLPWLKPHAHHLPDP
FFHRGMDGLQNLLGVTSAHVKERMAAGQDNHDDWLSLLLRARDDQGELLKFEEIASESLTLFMAAIETVSNTLSAMMYYL
ATSPSSLQKLQAEVDSIDIPGTVPPFTNVRALPYLDAVLNETMCLHSVLGIGLPREVLPGSKGVHLDSFYFPPGTVLSVP
IYAIHRSRDIWGQDANNFRPERWEKLSDRQKTSFIPFGHGPAACVGRNLAEVEMKIIAATLIKRYNFCMMDSEIESTEGT
TRKLIKVNIGIKRRQ*
>CYP54A1 N.
crassa AABX01000809.1 cont3.282
4170
MALTQLAHSASALLPLVLPSIAAILAFAIFQRYFAPNPLSNLPIV
GEEYHGYEKKRQAYLTKAKDLYLEGYTK
(0)3952
3824
FKHGLFRIVTPNRNSVIVVSPRFLDELKKLPDDVVSFDAANDD (0) 3696
3565
SMHTKYTLIPTHEPILPHTIKTSLTPSLPRLNPQLSEEVQIAFSQ
EIAPLMSSSPSDWAPININSKLLRIVAKVSGRVFIGPELCHDERYLEAAV
GYTVSVMEAQRAVERMNPWVRPIAAWRLKEVRKLAQMERDATAFLRPVVE
ARREKQRKGEEKDNDMLQWLMDSADQGQGKQHGKWGEDTTTTRKLARLQL
AISFAAIHTTTLVTTHAVYSLAADPKLQATLREEIQSVLQEHKGVFNTSA
LQAMKKTDSFLKETMRFHPLGQTSFNRKVLRTFALSNGQVIPKGSTIEVP
NYAVSRDPEAYPNPDVFDPLRFYNLRNEAREKGEAEQAASGQFVSVNKEF
LTFGYGRHACPGRFFAANEIKMILANLVMTYEMGLVEGETERYRDWDIAA
GTIPDPTKDVMFRKL*
2333
>CYP54B1 Magnaporthe grisea MG01391.4 45% to CYP54A1 AACU01000043 cont2.256
AI068604 revised to fill in gap
MSTTQLADVVADRLPLIASAAVILGVTFVVQYFFFKDPLANVPFVGTEFG
GEEARREQFLKDAKPFYLEGFRMNKVHKVTSPRTDTTVSIPAEFLEELKR
LPDDTISFGGAVNEVMAGKYTGIDGIEPTAPHLVKSHLTPALAKINPVLTEE
VARTVREELGSLEDW
TEVNIHSKLLRIVAIVSGRIFLGPELCHNEKYIESAIYYTMELNQGRQAI
FRLPAWQRPFRAWFLPEIKNLHKREREFYALIEPIVKARREARRSDPNYQ
APDDMLTWLEESQDKTTRKSIREIAKLQLGLSFAAIHTTTMTTTNIIYDL
AAHPEMIAELRQEASAALAAHDGAFTAPALHTMKKMDSVMKESMRMNPAG
YSAFMRKVLKPFTLSNGQEIPAGVTIEVPGYGVSRDPETFPNADSWDGLR
FFRLRESGETVGSSKQGGGRASAVEVSAQNQFVSVSKSSLGFGYGRHACP
GRFFASNEVKMILARLVLNYDVKLAGGATERYKNIEAAGSCVPDPTKMLL
FKERA*
>CYP54C1 Fusarium graminearum FG11536.1
AACM01000473 FGcontig1.473_scaffold10
MGDTQSAFDIEANRWPVLLTALLVCLVAAIAPKVGSVLRFWTIPVVGEEL
GSTEKRRKAYLGGARKLYSDGYQKLTIEQFKNGIFMITTSKSSPTIVISP
DFLPELKKLPDSILSMEAAVDESMETTYTKIETSVPIIPHTIKGHLTPAL
SRLSAIIADEVRQSLELSIPSCDDWTEVNIHHSLLRIVGMVSGRVFIGPE
LCRSEQYLDAAINYTMEVMGAQRAVQNMRPWLRPFLAQSQPEVKRLYQRI
AEAEAFLQPVVESRIEAMADLSYEKPDDFLQWLIDGKDKFPDKNSQNLAK
VQLGLTFAAVHTTTLTATNAFYDLAAMPDLQVELRDEVQEALLQSEGVFT
SNALQGMKKMDSFLKETLRVHPATMASFQRKVLKPFTLSNGQVIPAGLMI
EIPAVAVNSDPYIFPHADEFDPLRFYRIRTQAKDESSVENAAKEQFVSVN
QSSLTFGYGRHACPGRFFAANEIKMILAHALLRYDVKLVGSETRRYPNIE
FAHMSIPDPSRKLLFKAIGF*
>CYP54C2 Nectria haematococca fgenesh1_pg.scaffold_20000135
Necha1/scaffold_20:362069-363960
75%
to 54C1 small gap after GYQK? (5 aa), this seq looks right,
maybe
the 54C seq is too long here. Note LTIEQ can be removed from 54C and
the
intron boundary is preserved.
This gene model seems correct
MGNIQSFVDLAVNRWPTLLAIVVVCLTAAFGPTINRTILLRSLPVVGDGNAEKRRMAYLAGARKLYSDGYQK
(0)
FKDGVFTITTSR (1)
TSPIVVISPKFLPELHKLPDSVVSMDAAVDE (0)
TMETKYTKIETSVPIIPHTIKGDLTPSL (1)
NRLNPTIAQEVREALQLSIPSCDDWTEVNIHHSLLRIVGMVSGRVFIGPELCKSEKYLDAAINYTME
VMGAQRAVQQMRPWLRPFLASRLPAVKRLDQRIAEAEEFLNPIVKQRAEAIADPSAEKPDDMLEWLMNRK
DKFPDKNSQNLAKVQLGLTFAAIHTTTLTATNA (2)
FYDLAAMPDVQKELRVEIREALSQTSGVFTSQALQNMKKMDSFLKEVLRLHPATM
(1)
ASFQRKVLKPFTLSNGQKIPEGVTIEIPAVAISADSSVFPKADKFDPWRFYRLRQQAKDDGSAEKAALHQ
FVSVNQSSLTFGFGRHACPGRFFAANEIKMILANTILQYDIKLVDATERYPNIEFAHM
(0)
SIPDPSRKLLFKAIDV*
>CYP54C3 Cryphonectria parasitica
CB690595.1 60% to CYP54C2 N-term only, 55% TO
54C1
MATSTTSSLSETLSERFLVIVAAVLACALAYLGPKIISIIRLAALPVIGTE
LGNEEKRRQAYLQGARKLYYAAYDNFKNGLFKGAARLTTSRNANVIVVSPKFLPELNKLP
DSVVSMEAAVDDAMETKYTKIESHVPIIPHTVTGKLTPSLTRLNPTIARETAEALEL
EMPLREFTNWQEVNIHEKLLRIVGMXSGR
>CYP54C4 Cryphonectria parasitica
CB686707.1 CB688482.1
55% TO CYP54C1
TRPMPTCEDWTAVKINSVLLRIVAKASGRIFVGPELCHSEEYLEAAIRYTVEVIGAANAV
SNVPPWLRSFKASKLPEVQRLHERRKHAIKFMQPVVESRKDLDQKPDDLLQWLIDNEGNL
GDMSTWKLARTQLALSFAAIHTSTVVSTNVFYTLAVMPNEVILELRDEIRSVLGENNGNFT
SSALQSMKKVDSFIKETMRYYPFANHSFERKVMRTFTLSNGQVIPAGVILECSTAHNQDD
EVFPDASRFDPWRFSKLQEQEKEDGMDGAARHQMVSVTPNHLTFGYGRHACPGRFFAINX
IKMIIGTFLLNYDIKNIDGVK*
>CYP54C5 Fusarium oxysporum
82% to CYP54C1
FOXG_01238
MGNAQSPLDFVSNRWPIIVTALFACLVAAIGPRVVNALRLWTIPTIGEELGSTEKRRQAYLAGARKLYSAGYQKLTTFQF
KDGVFLITTSRTSPTIVISPDFLPELKKLPDATLSMEAAVDESMETKYTKIETSVPIIPHTIKGELTPSLSRLSLTIASE
VRDSLNLTMPPCDDWTEVNIHHALLRIVGMVSGRMFIGPELCRSEQYLDAAINYTMEVMGAQRAVQNMRPWLRPFRAQSL
PEVKKLYQRIAEAEAFLEPVVKTRTDAMNDPTYEKPDDFLQWLIDGKDKFPDKNSQNLAKVQLGLTFAAVHTTTLTATNA
FYDLAALPDLQIELRDEVREALAQSGGKFTSNVLQSMKKMDSFLKETLRVHPATMASFQRKVLKPFTLSSGQVIPAGVTI
EIPAVAVSSDSNVFPQADKFDPLRFYKLRTEAKDGGSVEKAANNQFVSVNQSSLTFGYGRHACPGRFFAANEIKMILAHA
LLQYDVKNAGDATERYPNMEFAHMSIPDPSKKLRFKSVEV*
>CYP54C5 Fusarium verticillioides
90% to CYP54C5 Fusarium oxysporum = ortholog
FVEG_00258 revised
MGNTQSLLDLVANRWPLPVTALLACVLAAIGPRVANVLRLWSIPTIGEEL
GNTEKRRQAYLGGARKLYSAGYQKLTDDQFKDGVFLITTSRTSLTIVISPDFLPE
LKKLPDATLSMEAAVDESMETKYTKIETSVPIIPHTIKGKLTPSLSRLSL
TIATEVRDSMNLTIPPCDDWTEINIHRALLRIVGMVSGRLFIGPELCRSE
QYLDAAINYTMEVMGAQRAVQNMRPWLRTFRAQSLPEVKKLYQRISEAEA
FLDPVVRRRTDAMNDPSYEKPDDFMQWLIDGKDKFPDKNSQILAKVQLGL
TFAAVHTTTLTATNAFYDLAALPDLQIELREEVREALSQSGGQFTSNALQ
SMKKMDSFLKETLRVHPATMASFQRKVLKPFTLSNGQVIPAGVTIEIPAV
AVSSDSNVFPHAEKFDPLRFYRLRTEAKDGASVEKAANNQFVSVNHSSLT
FGYGRHACPGRFFAANEIKMILAHALLQYDVKNLGDATERYPNMEFAHMVS*
>CYP55A1v1 F.oxysporum M63340
MASGAPSFPFSRASGPEPPAEFAKLRATNPVSQVKLFDGSLAWL
VTKHKDVCFVATSEKLSKVRTRQGFPELSASGKQAAKAKPTFVDMDPPEHMHQRSMVE
PTFTPEAVKNLQPYIQRTVDDLLEQMKQKGCANGPVDLVKEFALPVPSYIIYTLLGVP
FNDLEYLTQQNAIRTNGSSTAREASAANQELLDYLAILVEQRLVEPKDDIISKLCTEQ
VKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKANPSLAPQ
FVEELCRYHTASALAIKRTAKEDVMIGDK
LVRANEGIIASNQSANRDEEVFENPDEFNMN
RKWPPQDPLGFGFGDHRCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLGKINYTPLNR
DVGIVDLPVIF
>CYP55A1v2 Fusarium oxysporum
96% to CYP55A1v1
FOXG_12350
MASDAPSFPFSRASGPEPPAEFAKLRATNPISQVKLFDGSLAWLVTKHKDVCF
VATSDKLSKVRTRQGFPELNAGGKQAAKAKPTFVDMDPPEHMQQRSMVEPTFTPEAVKNLQPYIQKTVDDLLEQMKQKGC
ANGPVDLVKEFALPVPSYIIYTLLGVPFKDLEYLTQQNAIRTNGSSTAREASAANQELLDYLATLVEQRLVEPKDDIISK
LCTEQVKPGNIDKSDAVQIAFLLLVAGNATMVNMIALGVATLAQHPDQLAQLKANPSLAPQVEELCRYHTASALAIKRTAKEDVMIGDK
LVRANEGIIASNQSANRDEEVFENPDEFDMNRKWPTQDPLGFGFGDHRCIAEH
LAKAELTTVFSTLYQKFPDLKVAVPLEKINYTPLDRDVGIVDLPVTF*
>CYP55A1 Fusarium verticillioides
96% to CYP55A1v2 Fusarium
oxysporum
FVEG_10773
MASDAPSFPFSRAFGPEPPAEFAKLRATNPVSQVKLFDGSLAWLVTKHK
DVCFVATSDKLSKVRTRQGFPELSAGGKQAAKAKPTFVDMDPPEHMHQRSM
VEPTFTSEAVKNLQPYIQKTVDDLLEQMKQKGCANGPVDLVKEFALPVPSY
IIYTLLGVPFKDLEYLTQQNAIRTNGSSTAREASAANQELLDYLATLVE
ERLVEPKDDIISKLCTEQVKPGTIDKSDAVQIAFLLLVAGNATMVNMIAL
GVATLAQHPDQLAQLKADPSLSPQFVEELCRYHTASALAIKRTAKEDVMI
GDKLVRANEGIIASNQSANRDEEVFENPDGFNMNRKWPAQDPLGFGFGDH
RCIAEHLAKAELTTVFSTLYQKFPDLKVAVPLEKINYTPLNRDVGIVDLPVTF*
>CYP55A2
Cylindrocarpon tonkinense D78511
MASEPPSFPFQRASGMEPPAEFARLRATDPVSKVKLFDGSLAWL
VTKYKDVTFVATDERLSKVRTRPGFPELNAGGKQAAKAKPTFVDMDAPDHMNQRGMVE
SLFTLEHVKKLQPYIQKTVDDLLAAMKKKGCANGPVDLVKEFALPVPSYIIYTILGVP
FNDLDHLTNQNAIRTNGSSTAREASAANQELLDYLASLVEKRLEEPKDDLISKLCTEQ
VKPGNIEKADAVQIAFLLLVAGNATMVNMIALGVVTLFQHPEQLAQLKANPSLAPQFV
EELCRYHTASALAIKRTAKVDLEIGGKHIKANEGIIASNQSANRDADIFENPDEFNMN
RKWPAEDPLGYGFGPHRCIAEHLAKAELTTVFATLFKEFPDLNIAVPFEKINFTPLGG
DVGVVDLPVTF
>CYP55A3
Cylindrocarpon tonkinense D78512
MHATEDETTTIPRFPFQRASAFEPPAEFARLRANEPISQVELFD
GSLAWLVVKHEDVCRVATDERLSKERTRLGFPELSAGGKAAAKNKPTFVDMDAPAHMN
QRSMVEPFFTEDHVENLRPYIKETVQGLLNDMVANGCEEPVDLIEKFALPVPSYIIYT
ILGVPFEDLEYLTEQNAIRSNGSGTAQEAAAANQQLLKYLAKLVDQRLQEPKDDLIGR
LVDQQLVPGHIEKSDAVQIAFLLLVAGNATMVNMIALGVVTLMQNPSQLEELKADPTL
VPGFVEELCRYHTGSSMAMKRVAKEDMELGGKLIRAGEGIIASNQSANRDEDVFPNPD
VFDMHRDFDSRDGLGFGFGPHRCIAELLAKAELEIVFETLFATLPDLRVSIPLDEIEC
TPRHKDVGIVRLPVKW
>CYP55A4 Trichosporon cutaneum (a
basidiomycete fungus)
GenEMBL AB052733
MMLTRLGLRPLNSFTRALSTRAAPKFPFARASGMEPPAEFATLR
ATNPVSQVQLYDGSLAWLVTKYEDVIKVATDERLSKVRTRPGFPELSAGGKAAAQAQP
TFVDMDAPDHMKQRGLVEAFFTPEYVEGLKPYIQSVIDEALDKMAAKTQPADLVSEFA
LIVPSYVIYTILGVPLKDLEFLTLQNAIRTNGSSTAREASAASAGLLEYLGKLVDARM
DEPKDDLVSTLCKAVAAGKLDRTSAVQVAFLLLVAGNATMVNMIALGVATLAKYPSQL
ELLKADPSLAANMVQELCRYHTASAMALKRVALEDIVLGGQTIKAGEGIIASNYSGNR
DADAFKDPDVFDIRRTFDKDPLAFGWGPHRCIAETLAKVELTAVFETLYKRLPNLKPA
VPLEDIAYSPLDKDVGIVELPVTW
>CYP55A5v1 Aspergillus oryzae
GenEMBL AB055659
MNSEPVYPRFPFARPSGDEPPAEFHRLLRECPVSRVELWDGSHP
WLVVKHKDVCEVLTDPRLSKVRQRDGFPEMSPGGKAAARNRPTFVDMDAPDHMHQRSM
VSAFFNDEYVESRLPFIRDTVQHYLDRLIRAGKDGKEVDLVKHFALPIPSHIIYDILG
IPIEDFEYLSGCDATRTNGSSTAAAAQAANKEILEYLERLVDKKTTNPSHDVISTLVI
QQLKPGHIEKLDVVQIAFLLLVAGNATVVSMIALGVVTLLEHPDQLSRLLEDPSLSNL
FVEELCRFHTASALATRRVATVDIELRGQKIRAGEGIIASNQAANRDPEVFPDPDTFD
MFRKRGPEEALGFGYGDHRCIAEMLARAELETVFSTLFQTLPSLKLAIPKSEIQWTPP
TRDVGIVGLPVTWDRD
>CYP55A5v1 Aspergillus oryzae
GenEMBL BAC01275.1
cytochrome P450nor
MNSEPVYPRFPFARPSGDEPPAEFHRLLRECPVSRVELWDGSHPWLVVKHKDVCEVLTDPRLSKVRQRDG
FPEMSPGGKAAARNRPTFVDMDAPDHMHQRSMVSAFFNDEYVESRLPFIRDTVQHYLDRLIRAGKDGKEV
DLVKHFALPIPSHIIYDILGIPIEDFEYLSGCDATRTNGSSTAAAAQAANKEILEYLERLVDKKTTNPSH
DVISTLVIQQLKPGHIEKLDVVQIAFLLLVAGNATVVSMIALGVVTLLEHPDQLSRLLEDPSLSNLFVEE
LCRFHTASALATRRVATVDIELRGQKIRAGEGIIASNQAANRDPEVFPDPDTFDMFRKRGPEEALGFGYG
DHRCIAEMLARAELETVFSTLFQTLPSLKLAIPKSEIQWTPPTRDVGIVGLPVTWDRD
>CYP55A5v2 Aspergillus oryzae
GenEMBL BAE61721.1
6 aa
diffs to CYP55A5v1
MQLEPVYPRFPFARPSGDEPPAEFHRLLRECPVSRVELWDGSHPWLVVKHKDVCEVLTDPRLSKVRQRDG
FPEMSPGGKAAARNRPTFVDMDAPDHMHQRSMVSAFFNDAYVESRLPFIRDTVQYYLDRLIRAGEDGKEV
DLVKHFALPIPSHIIYDILGIPIEDFEYLSGCDATRTNGSSTAAAAQAANKEILEYLERLVDKKTTNPSH
DVISTLVIQQLKPGHIEKLDVVQIAFLLLVAGNATVVSMIALGVVTLLEHPDQLSRLLEDPSLSNLFVEE
LCRFHTASALATRRVATVDIELRGQKIRAGEGIIASNQAANRDPEVFPDPDTFDMFRKRGPEEALGFGYG
DHRCIAEMLARAELETVFSTLFQTLPSLKLAVPKSEIQWTPPTRDVGIVGLPVTWDRD
>CYP55A5 Aspergillus flavus
99% to CYP55A5v2 Aspergillus oryzae, 2 aa
diffs
Supercontig 11: 146268-147914 (-) strand
AFL2G_09432
MQLEPVYPRFPFARPSGDEPPAEFHRLLRECPVSRVELWDGSHPWLVVKHKDVCEVLTDPRLSK
(0)
VRQRDGFPEMSPGGKAAARNRPTFVDMDAPDHMHQR (2)
SMVSAFFNDAYVESRLPFIRDTVQYYLGRLIRAGEDGKEVDLVKHFALPIPSH
(0)
IIYDILGIPIEDFEYLSGCDATRTNGSSTAAAAQAANK (2)
EILEYLERLVDKKTTNPSHDVISTLVIQQLKPGHIEKLDVVQIAFLLLVAGNATVVSMIAL
(0)
GVVTLLEHPDQLSRLLEDPSLSNLFVEELCRFHTASALATRRVATVDIELRGQ
(0)
KIRAGEGIIASNQAANRDPGVFPDPDTFDMFRK
RGPEEALGFGYGDHRCIAEMLARAELETVF (1)
STLFQTLPSLKLAVPKSEIQWTPPTRDVGIVGLPVTWDRD*
>CYP55A6 N.
crassa AABX01000354.1 cont3.356 NCU06137.1 (version3)
153215
MGALTENLEFPFRRASGLDPPPEYAWLRKTDPVTQVRLFDGSL
AWLVTKYHDVCQVATDERLSKERTRPGFPELAAGGKEAAKNRA
TFVDMDPPKHMQYRGMVQPIFEMEHVKELEPYIQKTVDDLLER
MKNMGCEGGPVDLVQNFALPVPSY (0) 152757
152692
IIYTILGVPVEDLDFLTQQNSIRTNGSSTAREASAANQ (2) 152579
152519
ELLNYLRRLAEQRLQEPKDDLISKLMTEQVKAGKLDTADAVQM
AFLLLVAGNATMVNMIAL (0) 152337
152273
GIVTLFLNPSQLEELKRDPSVVPAFVEELSRFHTASAMAIRRV
AKEDLEIRGKTIKKGEGVIASNLSANRDEEVFKDADKFDMHRE
WPVKELGFGWGEHRCIAEFLAKAELKAVF (1) 151893
151771
ETIFKKLPDLKIAVPFDEIEYTPLDRDVGIVKLPVTW* 151658
>CYP55A7 Trichosporon domesticus SBUG 752 (a
basidiomycete fungus)
GenEMBL AY044231 and AY044232
AEFAKLRATDPVSKIKLFDGSEAWLVTKYRDVCKVATDDRLSKV
RTRPGFPELNAGGKEAAKAKPTFVDMDKPDHMKQRG
>CYP55A8 Fusarium graminearum FG11585.1
AACM01000475.1 FGcontig1.475_scaffold11
MSSDPPSFPFQRASGSEPPAEFARLRATEPVSQVELFDGSLAWLMTKYKD
VTFVATSDKLSKVRTRTGFPELTARGKQAAEAKSTFVDMDPPDHMRQRGM
VESLFTPEAVKKLQPYIKKTVDDLLENLKQKGSANKQVDLVKEFALPVPS
IIYTILGVPFDDLQYLTQ
QNAIRTNGSSTAREASAANKELLLYLASLVEKRLEEPKDDLISKLCTEQ
VKPGNIEKPDAVQIAFLLLVAGNATMVNMIALGVVTLAQHPEQLAQLKSN
PSLAPQFIEELCRFHTASALAMKRTAKEDVEIGGKLIKVNEGIIASNQSA
NRDEDIFENANQFNINRKWPAEDPLGFGFGDHRCIAEHLAKAELITVFAS
LYQKFPDLNVVIPLEEVNYTPLSGDVGIVDLPVTL*
>CYP55A9 Nectria haematococca
fgenesh1_pg.scaffold_30000098
Necha1/scaffold_30:272059-273639
92% to CYP55A2 Cylindrocarpon tonkinense D78511
79% to CYP55A8 Fusarium graminearum
This gene model seems correct DRN 2/5/06
MASEPPSFPFKRASGMEPPAEFARLRASDPVSKVKLFDGSLAWLVTKYKDVTFVATDERLSK
(0)
VRTRKGFPELSAGGKQAAKAKPTFVDMDAPDHMKQR (2)
GMVEPLFTRKHVEKLQPYIQKTVDDLLAAMKKKGCATGPVDLVKEFALPVPSY
(0)
IIYTILGVPFNDLEYLTNQNAIRTNGSSTAREASAANK (2)
ELLDYLASLVDKRLEAPEDDIISKLCREQVKPGNIEKADAVQIAFLLLVAGNATMVNMIAL
(0)
GVVTLFQHPEQLAKLKENPSLAPQFVEELCRYHTASALAIKRTAKVDLEIGGK
(0)
HIKANEGIIASNQSANRDADIFENPDEFNMNRRWPAEDALGYGFGAHRCIAEHLAKTELTTVF
(1)
ATLFKELPDLKIAVPFEKINFTPLDRDVGVIDLPVTF*
>CYP55A10 Nectria haematococca
fgenesh1_pg.scaffold_28000090 [Necha1:94366]
Necha1/scaffold_28:245547-247185
96% to CYP55A3 Cylindrocarpon tonkinense D78512
Note: the very high similarity suggests a very
close relationship between the
Two species. This is higher than the ortholog pair matches between
F. graminearum and N. haematococca
This seq is originally of bacterial origin
(P450 B type not E type) similar to CYP105s
This gene model seems correct DRN 2/4/06
MHATEDETIIIPRFPFQRASAFEPPAEFARLRANEPISQVELFDGSLAWLVVKHEDVCRVATDERLSK
(0)
ERTRLGFPELSAGGKAAAKNKPTFVDMDAPAHMNQR (2)
SMVEPFFTEDHVESLRPYIKETVQGLLNDMVAKGCEDPVDLVEKFALPVPSY
(0)
IIYTILGVPFEDLEYLTEQNAIRSNGSGTAQEAAAANQ (2)
QLLKYLAKLVDQRLQEPKDDLIGRLVAQQLVPGHIEKSDAVQIAFLLLVAGNATMVNMIAL
(0)
GVVTLMQNPSQLDELKADSTLVPGFVEELCRYHTGSSMAMKRVAKEDMELGGQ
(0)
LIRAGEGIIASNQSANRDEDVFPNPDVFDMHRDFDSRDGLGFGFGPHRCIAELLAKAELETVF
(1)
ETLFTTLPDLRVSIPLDEIECTPRHKDVGIVRLPVVW*
>CYP55A11 Nectria haematococca
estExt_fgenesh1_pg.C_880004 (better model)
Necha1/scaffold_88:11555-13495
69% to AB226066.1 Aspergillus oryzae cDNA
58% to fgenesh1_pg.scaffold_28000090
54% to CYP55A8 Fusarium graminearum
58% to CYP55A3 Cylindrocarpon tonkinense
same as fgenesh1_pg.scaffold_88000004 which is
too long at
SNAQAHPAP between MHQ and RQM
Note: This gene has one extra intron at the
N-terminal
that only codes for 3 amino acids
This gene model seems correct DRN 2/5/06
MAS (1)
DPHFPFARQNGAEPAPEFQQRLTSCPVARVELWDKSHPWLVVKHKDVREVLTDPRLSK
(0)
NRQKEGFPEMSAGGKAAAKNCPTFVDMDPPDHMHQ R (2)
QMVAAFFTPEYVEQRKPWIKGVVQHYLNEFINARKGQNSIDLVEHFALRVPSH
(0)
IIYDILGVPLRDVDYLTKCNATRTNGSATASAAQDANT (2)
ELLDYFAKLIDKKIESPEPSNDVISSLVANQLANGQLDKKDVVQISFLLLVAGNLTMINMIAL
(0)
GVITLLDHPDQLDALIRDPSLSKPFVEELCRFHTASSFATRRVAKVDVKIRGQ
(0)
EVKAGEGIIASNQAANRDPDVFSDPNVFDMFRKRGSEEALGFGWGDHRCIAESLARAELEAVF
(1)
STLFQTLPTLKLAIPNSEIKWTPPIKDIGVSELPVTWSSSHVGGRRSQL*
>CYP55A12P Aspergillus niger
gw1.11.1089.1|Aspni1
48% to CYP55A5v1 aa 53-257, this
is a pseudogene
LKSIPVSRKNLFDGSCP*MVIKLKETYNILVDPRLLK (0)
VRQRDRYPEISAGAKKRAENSPTFINMDPSVHGHQRFIARLNS*
(2)
SFKPEYIKSCEGFNKHTVRRYLERLIKTKADQQSVDRVENFTLSIPSH
()
IIYNLLGIPDKDFIYLTNCNAT*TNSGNTAGAAQSANE (2)
KYLKYFDHLLDERIANPGDNIISSLAKEQLQQGNLER*DII
>CYP55A13 Uncinocarpus reesii
71% to CYP55A5v1 Aspergillus oryzae
UREG_06342.1
MATEATPPKFPFARPRGAEPPAEFAKLRATNPVSRVELWDGSHPWLVVKYNDVCSVLTDERLSKQRQRDGFPEMSAGGKA
AAKNRPTFVDMDPPDHMRQRGMVTSFFTPEYTESIKPQIQKTVDRYLEEMIKGGCEKPVDLVEKFALPIPSCIIYDILGI
PFEDSDSLTQWNAIRTNGSSTAAAAATANTELLGYLDKLVDKKIANPQNDLISTLVTEQLQPGNIDKLDVVQISFLLLVA
GNATMVNMINLGVVTLLEHPDQLEDLKRDPSLAKPFVEELCRYHTASALATRRVAKVDITLNGQLIKAGEGIIASNQAAN
RDEDIFPDPDKFDIHRKRGSESALGYGYGDHRCIAEGLSRAELEAVFSTLFQRLPNLRLGIPHSEIKYSEPTMDVGIAEL
PVVW
>CYP55A14 Histoplasma capsulatum
73% to CYP55A13
HCB04560.1
MCVCLSARSKSAIPARSAIVARNQRCNMSTEAAPPKFPFSRPSGAVPPLEYAKLRATNPVSRVTLWDNSQPWLVVKHKDI
CSVLTDSRLSKERTRAGFPEMNPGGKEAAKNRPTFVDMDPPDHGRQRNMVASLFTRESSETMRPHIQATADALLDEMIKQ
GCEKPVDLVEKFALPLPSYIIYGILGVPKEDLAYLTECNAVRSNGSSTAAAASNANKELLDYIGNLADKRLEKPGNDMIS
KLVVEQLKPGHIDRLDVIQIAFLMLVAGNATLVNMISLGIVTLLQHPKQLADLKANPSLAPKFVEELCRYHTASAMATRR
VAKEDIMLGGHLIKAGEGIIAATQSGNRDEDIFPNPDVFDMHRTRGSEVALGYGYGEHVCVAEGLARTELEVVFSTLFRR
LPNLKLGIPLSEVKYSPPDADVGITELPVVW
>CYP55A15P Fusarium oxysporum
74% to CYP55A2 Cylindrocarpon tonkinense
FOXG_14888
SNPRSFPFERASVLEPPAEFAKLRATDPVSQVKLFHGSLPWLVTKHKDVVFVATPDKLSK
(0)
VCTRPGFPELDAGGKEAAKAKPT (?)
LDMDSPDHMHQR (?)
RRMVEQIFTQEAVEKLQPYIQKTVDDLLEDLKQKGCADGPVHLVKIFALPAPSY
(0)
VIYTILGAPFHDLEYLT*QNAIRSNGSSTAREPSAANN (2)
REFLDYVANLADK*LEEPQDDLISKLCTEQVKPGNIEKADAVQISFLLLVAGNATMVNMIAL (0)
GVITLPQHPDQLSELKP*SIPGPQFVEELCRYHTASALAIK
RTAKEDLEISGK (0)
SKGIIASNQSANRHEDAFKNPD*FDMDCKWLVEDALGFGFDGHRCIDEHLAKTEPTTVFGT (?)
LYRKFPDLKNAVPLEEVHYTPLCQDVGVVDLPVTF*
>CYP55A16P Fusarium oxysporum
83% to CYP55A11
FOXG_17502
INYDILGVALKDVDYLTQCNATRTNGSATASAAQDANM (2)
ELLNYFAKRVDKKIESPEPSNDVIGSLVSNELAN &
VDKKHVVELSFLLLVAGNLTMINMIALV (1)
CVLTLLEQPDQLDALIQDPSLLKPFVEELCRYHTASSFATRRVAKVDIKVRGH
()
EVKAGEGIIA*NQAANRDPDVVPDPNVFDLF*KRGSEEALGFGWGDHRCIAASLARAEPEAVF
(1)
STLFQTLPTLKLAIPSSEINGSAPNKDIGVSELPVTWSSPQVS*
>CYP55A17 Aspergillus terreus
73% to CYP55A13 Uncinocarpus reesii
ATEG_06140.1
MTTTRAVSRPSLWAKYRPVPRPRFSYVSFNSLAGFTSRSGPLREAAAGTQ
TDAPEFPFARPRAAEPPAEFAKLRSSCPVS
RVKLWDGSLPWLVVKHEDVCNVLTDTRLSKERSRAGFPEMNPGGKAAAKNRPTFVDMDPPNHMRQR
(2)
RSMVSAFFTPEYIDSMKPFIQSTVDNVLNDMIAKGCDEPVDLVERFSLPIPSI
(0)
IIYHIIGVPTEDMDYLTQKNAVRSSGSSTAAAAQNANEELLAYLGSLVDKRIADPKKDLISTLITEQ
LNPGHLDRLDVVQLAFLLLVAGNATMVNMINLGVVTLLEHPSQLEELRRDPLLARKFVEELCRFHVASSFATRRVAKVDI
TLRDKHIKAGEGIIASNQSANRDEDVFPDPDTFNMHRETDSEQNLAYGYGDHRCIAEGLARAELEAVF
(1)
SCLFRLPNLKLGVPHDQVRYSEAHKDVGIDELPVTW*
>CYP55A18 Trichophyton rubrum
ESTs DW700172.1, DW689200.1, DW681558.1
72% to CYP55A14 Histoplasma capsulatum
MFISRPVITSIGSRVSVQLTTTGLRAMATAV
PKFPFSRPRGAEPPAEYARLRATDPVSKVELWDGSQAWLVVKHKDICSVLTDQRLSKQRN
RPGFPELDAGGKEAAKRKPTFVDMDPPEHMQQRSMVEPLFTREHIDGMRPHIQQTVNTLI
DEMIIGGGKPAVDIVEKLALPTASYIIYGILGVPFKDLEYLTQQAAIRSNGSATAAAASA
ANQQLLEYIGGLVDQRIAEPRNDLISKLVVEQLKPGHLQRDDVIQMAFLMLVAGNATMVN
MINLGIVTLFENPSQLADLKKDLSLVPQFVEELCHFHTASAMATRRVAKVDI
ELGGKTIKAGEGIIAATQSGNRDADVFPDPDTFNMHRKRGAESAFGFGYGEHRCVAEWLA
RAELEIVFTTLFRRLPDLRLAVPLDEVKYSDPSKDVGITELPITW*
>CYP55C1 Aspergillus niger
fgenesh1_pm.C_scaffold_5000072|Aspni1
40% to CYP55A1, 40% to CYP55B1
MYPFARPPKSYDPPAELAELRHQGPTERVQLFDGRPAWIVTRDKEVREMLSSDKFSNDRYNRDGYPEIHSGTKKDGVRPT
FVHMDDPKHARHRAMTESFFTPEATEAVKPQVQEVVDSLIDSIKERGCNNGPIDLVKELATVVNPKVILLSILKVSEKEA
NELIQSSSALGGTSGSASESGHTDLHEYISQLIDARIEKPRRPQDDLLSKLVVDEYRQANLDRDDLINLVYMIFVAGNSA
IQSSIVLGVITLLQHQDQLEELKENPGLAGRVVEEILRYHTPSALNSRRVTTTDITLGGKKIKSGSGVIGSVRSANRDER
VYPDADKFSIHRQVDPHQNLAFGHGPHNCQGQWLSRMELQAIFSSLFRKLPNLRLAIEPSELEYTSPTQNVGVLRLPVVF*
>CYP56A1 S.
cerevisiae DIT2 X55713
MELLKLLCLILFLTLSYVAFAIIVPPLNFPKNIPTIPFYVVFLP
VIFPIDQTELYDLYIRESMEKYGAVKFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGN
QKKIPYSALAAYTGDNVISAYGAVWRNYRNAVTNGLQHFDDAPIFKNAKILCTLIKNR
LLEGQTSIPMGPLSQRMALDNISQVALGFDFGALTHEKNAFHEHLIRIKKQIFHPFFL
TFPFLDVLPIPSRKKAFKDVVSFRELLVKRVQDELVNNYKFEQTTFAASDLIRAHNNE
IIDYKQLTDNIVIILVAGHENPQLLFNSSLYLLAKYSNEWQEKLRKEVNGITDPKGLA
DLPLLNAFLFEVVRMYPPLSTIINRCTTKTCKLGAEIVIPKGVYVGYNNFGTSHDPKT
WGTTADDFKPERWGSDIETIRKNWRMAKNRCAVTGFHGGRRACLGEKLALTEIRISLA
EMLKQFRWSLDPEWEEKLTPAGPLCPLNLKLKFNENIME
>CYP56A2 Saccharomyces paradoxus NRRL Y-17217
AABY01000059.1
91% to CYP56A1
46799
MELFKLLGLTLFLTISYIAFAIIVPPLNFPKNIPTIPFYVVFLPVfVFPIDQTELYDLYIR 46620
46619
ESMEKYGAVKFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVI 46440
46439
SAHGAVWRDYRNAVTNGLQHFDDTPIFKNAKLLCTLIKRRLQEGQLSIQMGPLSQRLALD 46260
46259
NISQVALGFDFGTLKHEKNAFHEHLIRIKKQIFHPFFLTFPFLDLLPIPSRKKAFKDVAS 46080
46079
FRELLVKRVQDELVNTYKFEQTTFAASDLIRAHNNEIIDYRQLTDNIVIILVAGHENPQL 45900
45899
LFSTSLYLLAKYSNVWQERLRQEVNGVTDPKILADLPLLNAFLLEAVRLYPPLSTIINRC 45720
45719
TTRTCKLGPEIVIPKGVYVGYNNFGTSHDPRTWGATADDFKPERWGSDIETIRKNWRMAK 45540
45539
NRCSVTGFHGGRRACLGEKLALTEMRITLAEMLKQFRWGLDPEWEEKLTPAGPLCPLNLK 45360
45359
LKFTENITE* 45330
>CYP56A3 Saccharomyces bayanus MCYC 623
AACA01000139.1
Sbay_5318
83% to CYP56A1
23165
MSILQLIGFILLIIISYIAFVVVVPPLNFPRNIPTIPFYVVFLPVIFPIDQTELYDLYIR 22986
22985
EPMEKYGAVKIFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVI 22806
22805
SAHGKVWRDYRNAVTNGLQHFDDAPISKNAKTFCNLIKKRAQNGESSIQMGPLSQRLALD 22626
22625
NISQVALGFDFATLTQDKNALHELLVHIKKQIFHPFFLAFPFLDLLPIPSRRKAFRDVAS 22446
22445
FRELLVKRVQDQLINNYKFEQTTFAASDLIRAHNNEVIDYKQLSDNIVIILVAGHENPQL 22266
22265
LFNTSLYLLAKYSTEWQNSLRQEVESVTNSKALADLPLLNAFLFEAVRLYPPLSTIINRC 22086
22085
TTKLCKLGADIVIPKDVYVGYNNFGTSHDPKNWGPTANDFRPERWGSDIETIRKNWRIAK 21906
21905
NRCTVTGFHGGRRACLGEKLALTEMRITLAEMLRQLEWTLDPEWEEKLTPAGPLCPFNLK 21726
21725
LNFKERLPS* 21696
>CYP56A4 Saccharomyces castellii NRRL Y-12630
AACF01000075.1 Scas_Contig632.25
63% to CYP56A1
43945
MPALRVILSLLIVLVGYVIFKVVWPPLNFPRNIPTIPCYVVFLPIIFDIDQVDIYNTYIK 43766
43765
VQMEKYGAVKIFFGSRWNILVSKPEYLAQIFKEEDVFAKSGNQKKIPYSAIAAYTGDNII 43586
43585
SAHGDVWRKYRSIMTNGLQHFKEEPFICNAKKFCGLLRKNRGPTGNVLMGPLIQRLTL 43412
43411
DNISQVVLGFNFGTLSEETNELHQHLIKIKKQIFHPFFLTFPFFDMLPIPSRKKAFQDIS 43232
43231
KFREVLVSRVKNDLINNYKFEQTSYVSSDLIKAYNNNIIDYKQLTDNIVILLVAGHENPQ 43052
43051
LLLSNCLYLLAKYPSWQKLIWKETQNISNYKDLNELPLFNSFLFEVVRLYPPLNIIINR 42875
42874
KTNKKCRMGQDIIVPKNTYVGYHNFGVTHNRNVWGNTAEEFDPRRWGTNIADIMIAWRSS 42695
42694
KNSCKLTSFHGGRRACLGEKLGFVEMRISIFEIIQQFELTLPKEWKEKMTPAGPLCPYNL 42515
42514
QLNIKSREKDVGVCE*42467
>CYP56A5 Candida glabrata strain CBS138
CR380952.1, CAG59007.1
57% to CYP56A1
MLNILVFGFICLVLCWILTICFPPISFPNNIPTIPFYSVFIPQY
YNIDQVQFYNLYIREKLEKYGAVKFYFGSRWNILVSRPEFLNNIFKNEDTFAKSGNQQ
KIPYSVLAAYTGDNVISAHGVNWQKYRKPIKDGLQHFDIGILLKNAMKFCELIKEDMR
PFKYHCNFKIIPYIQRLTLDNICRVGLGFEFGAIDEDNNSLHRQLIQIKKQIFDPFYL
NFPMFDRLPIPSRLLAFQNVENFRSSLVDKVQKQLIKTYKFEQANTSGSALVRAYNNG
ELTYKQLTDNIVILLVAGHENPQLFISNLIYLLGKYHDTWQVDIRNEILNNEENNLSE
LPLLNSFLYECLRYYPPLSVIINRKTTKRCMLGPGIVVPKDTYVGYHNYSTCHDSNFW
GHTSDIFDPTRWGKDIETINKAWKTTKNNCILNTFHGGKRACLGEKLVFVSTRIIIAE
FLSSFEWKLSPLWVEQMTHAGPLCPKDLALDIRVRDTSMQIQKLNKYL
>CYP56A6 Ashbya gossypii (= Eremothecium gossypii)
AE016819, NP_985947.1, 54%
to CYP56A1
MTANIVLVLLGGLVLNYIRSIVLPPWGFPRNIPTIPFYVTFLTT
LFDIDQKELFELYIRKPMEKYGAVKIYFGNRWNILVSKPEFLAQMFKDEDTFAKSGNH
IKIPYSILALYTGDNVISSHGLAWKKFRGALTQGLQFFDPSPLSANAEKFIGFIERDM
KKNNGEVLMPALIQRLALANIAQIALGFDIGTLDPERPSKLQQQLEEVKKHIFHPLYM
NFSFLDRLPIPSRIRARQQVERFRSDLLQEVRRNLIINYKYEQTSYAASDLIRVYEHG
EITEKQLTDNIVILMVAGHENPQLLLTTCLYMLAKYPEWQARLRQQAVTLQDDLLNDS
VEFNQFLFETVRVLPPLGQIINRKTSHKCKLGPEIVLPKDTYVGYQVYGTGTSTQVWG
PDAAEFKPERWGSTNATVHETWRRSKNTGAMGAFHGGRRACLGEKMGLMETRVALAHM
LRKLEWTLSPNWKDRVTPAGPLCPFMLKLQFTRIQEPLAAELTA
>CYP56A7 Kluyveromyces lactis NRRL Y-1140
XM_452498, KLLA0C06743g
49% to CYP56A1, 53% to 56A6
MLSLVLGIISSGILLSFLCLVCFPIGLPWSLPTIPIYVSFLPIL
TDMDQLEIFERYIRHPMEKYGAVKIFFANRWNILTSKPEFLNIMFRDEDTFAKSGNQK
KIPYSLLAKYTGDNVISAHGKVWMKYRSCIQNQLNVFDSKPLIDNAQLFVKLLKKSIE
DNTEGTVLLPPLIQRLTLANIAKIALGFDIGTLKFDEHDNICRSRLHEKLNQVKQQIF
KPVFLSFPFLDLLPIKSRQRAKIDIIQFRDMLLDTVYKNLIHNYKFEQTNNAAAGLIR
EWKLQGITDEQLKDNLVIILVAGHENPQLLLSTLFYLLAKHQNWQYAIREELLSVDRN
EDILNSFKLTAFIYEALRMFPPLGQIINRRTTRKCQLGPGIIIDKDVYCGYNVYGTGT
ATSVWGETAKQFIPERWGENSNELANNWKKHKYDASMSAFHGGRRSCLGEKLALMEMK
YVLYYVLMNFHIELHPQWKEKMTPAGPICPKMLKVKLTILKDPQDQRSDSLYSSAGET
LSENI
>CYP56A8 Saccharomyces mikatae
90% to CYP56A2 Saccharomyces paradoxus Smik_4197 partial seq
MGPLSQRLALDNISQVALGFDFGALKQEKNAFHEHLICIKRQIFHPFFLTFPFLDLLPIPSRKKAFKDVASFRELLVKRV
QDELINNYKFEQTTFAASDLIRAHNNEIIDYNQLTDNIVIILVAGHENPQLLFSTSLYLLAKYSNKWQERLRREISGITD
PKVLADLPLLNAFLFEAVRLYPPLSTIINRCTTRTCKLGAEIIIPKNVYVGYNNFGTSHDPKNWGSTAYDFEPERWGSDI
ETIRKNWRTAKNRCTVTGFHGGRRACLGEKLALTEMRITLAEMLRQFRWELDPEWKEKLTPAGPLCPFNLKLKFKKNVAE
>CYP56A9 Saccharomyces kudriavzevii
AACI02001147.1, AACI02000561.1
85% to CYP56A3
MGIFKILGLILFLIISYIAFVVVVPPLNLPKNIPTIPFYVIFLPVIFPID
QTELYDLYIRESMEKYGAVKIFFGSRWNILVSRSEYLSQIFKDEDTFAKSGNQKKIPYSA
IAAYTGDNVISAHGKVWRDYRNAITKGLQHFDDAPISKNAKLFCNKIKERVQNGQVSVHM
GPLSQRLALDNISQVALGFDFATLKHEKNALHELLIHIKKQIFH
PFFLTFPFLDLLPIPS
(67 aa gap)
PQLLFYTSLYLLAKYSSKWQERLRQEVKNVTDPKALADLPLLNAFLFETVR
MYPPLNTIINRCTTKVCKLGMDIVIPKNVYVGYNNFGTSHDAKNWGPTANDFEPDRWGSD
IETIRKNWRLAKNRCVVTAFHGGRRACLGEKLALTEMRITLAEMLNQLKWSLDPEWEEKF
TPAGPLCPLNLMLRFKENVAK*
>CYP56A10 Saccharomyces kluyveri
AACE03000001.1 Sklu_Contig1634.3 Cyan region
is an insertion
60% to CYP56A3 Saccharomyces bayanus w/o the insert
MITTIALSFLTLIVIFSLKIIVPPWNFPNNIPTIPFYVTFLTTFFDLDQEDIFRLYLAEPLEKYGAVKIYFGSRWNILVS
RPTYLSQMFKEEDTFAKSGNQKKIPYSVMAEYTGDNVISAHGKIWKLYRNSVTNGLQFFDHKPMVENARLFCSLLKEQLNKE
CGQNLNYNKLSDKSKKEPCSNKAISLPECDDTNISILSQ
SASLEMADYIQRLTLANISQVALGFDFGTLTEDKAPLHQ
QLKYVKKQVFKPLFLNFPFLDKLPLPSRQSAREEVSKFRKNLVDQVRENLMDNYLYEQTSFASSELIRNYNREKLNEKQL
TDNIVIIMVAGHENPQLLLTTLLYMLAKHHSTWQVRLREELRSCSMTEIHELPLLNAFFFECIRMYPPLGQIINRCTSKT
CVLGRDIVIPKGSYVGYNVYATGRSRTVWGNDSNEFRPERWGLSYNEVMDTWRHSKNSCAMSAFHGGRRACLGEKLALTE
LRITVAEMLTQFQWRLAPDWKDKMTPAGPLCPLNLKLKIEPLNQ
>CYP56A11 Kluyveromyces waltii
59% to CYP56A10 Saccharomyces kluyveri kwal_162-g20.1
similar insertion as in 56A10
MNSILWGLIGVIFFLILRIVVPPFNFPRNIPTIPFYVTFLATIWDLDQEDIFNLYLREPLEKYGAVKLYFGSRWNIVVSR
PEFLAQMFKDEDTFAKSGNHKKIPYGVIAAYTGENVISAHGAIWKTFRRAITPGLQLFDHTPLVKNADLFCSLISKRLTK
SGSSSIGGSTSSLDEKESWQFPTA
ASGTLLMSELIQRLSLANISEVALGLDIGTLTEESPELHLKLKNVKSHIFKSLYLN
FPLLDKLPIPSRQRARGYVEDFRRCLMKAVEMNLLNNYTFEQTSFSSSDLIRSYNREEISKKQLIDNIVIIMVAGHENPQ
LLLTTCFYMFGKNRKWQDLVREEVQGCGIENLNDLPLLNSFIFECIRMYPPLSQIINRCTTKKCVLGTDIVLPENVYLGY
NVYSTGRYKSAWGDNADCFIPERWGNNIEEITKEWRHRKNTCAMAAFHGGRRACLGEKLALMEVRIAMAAVLKNFEWTLA
ASWVDKVTPAGPLCPAGLEIEISELSKH
>CYP56A12 Kluyveromyces polysporus
Kpol_364p9
62% to CYP56A3 Saccharomyces bayanus
MEFFIKFIIFCFVIFGVFIFKVVSPPLNFPRNIPTIPFYVSFLPIFYSIDQTELFELYLRKPLERYGAVKYFFGSRWNIL
VSKRLFVKQMFKNEDVFAKSGNQKKIPYSLLALYTGDNVISAHGEIWKTYRSVVTNGLQHFDYEPLYKNSKLFCDLIEKS
LETEENSESTVTVGPLIQRLALANISQVVLGFDFGTLTEEKCALQDHLIRIKKQIFHPFFLTFPFFDMLPLPQRRKGFKD
VSAFRNELVSKVRNDLINNYKFEQTTFTSSDLIRAYNNKLINYQQLTDNIVVLLVAGHENPQLAITTILYLLGKYHDSWQ
IAIRNEIGKLSKHDDLLQLPILNSFIFEALRVYPPLSIIINRCTTKTCRLGNDIVIPKGAYVGYHNYSTTHNFESWGDDS
DEFNPNRWGKTIEAIFHNWKVAKMECTLPTFHGGKRACLGEKLALAELRLCIAEILKRFEWKLSKSWNNKMTPAGPLCPL
NLKLDFKKIESE
>CYP56B1 Aspergillus nidulans AN2706.1 43% to CYP56A1
547 clan
revised 7/18/07
MLVTLTVLFLGLVGILASFLTYLFTPPQFFPKGLPTIPFYYTLIPLLNQT
LKRAPTDQVTLYHRYLSTPLRTHGAVKLFFGGRWNILITKPSYIAEVLKN
EDLYAKSGNQKKIPHSVLAQYTGDNIISSHGENWKLYSSIFKPGLQRDYD
PSGIWRNASLLVQMISQDIKRKSPVDINPLMQRYALANLSEVLLGTTFDT
LQKPAASLHAFQLLIKPKIFDPIFLNFPVLDYLPLQTREEARKLVTRFTD
ELIETVRKGHTTCDHEKEHTRNLGCRLLYACESGLFTEMQLRHNMISAFL
AGHENPQLLLVSSLFLLAEHPEMQESLRAEISALNDLEPAYNALSALPLL
TSTIYEVLRLYPPISQLINRRTTAPTLLGGEIPIPAGTYVGYNAYATNRD
IGFWGPDANEFKPSRWGNTMEEINALFRRANAKGAFISFHGGRRTCLGQR
FALLEGRVTLAKLLMCVRWEIDPSWQRGMTPAGPLYARNLQLRFSNISGAGKAGAS
>CYP56B2 Uncinocarpus reesii
59% to CYP56B1
Aspergillus nidulans
UREG_00550.1
MLTAYSLFSTGLLAVAIITILLLFVAAYLFSPPGSFPRNIPTIPFYYALLPLVKDNDQEVLYRRYLEPLFEKHGAAKIFF
GGRWNILVQRPSYIAEVFKFEDIYAKSGNHVKIPHSVLAEYTGDNIISAHGENWKLYRSVLQPPLQQDQDPEPIWRNARL
LIDLLFEEQKSSAGGSVLLPQLLQRYTLANLAEGLLGTSFETLQRKDAALHEFQMQIKPLIFSPVFMNFPFLDHLNLPSR
KKARQLARQFASKLCAVVQQGHQHAHNDKSTSNVGCSVIGAFEEGILTEKQFRNNMVSVFLAGHENPQLLLVSMIFLLGE
HQAVQEKVRRELFSLGDDELAYPVLQSAPYLTSVIYETLRMYPPISQLINRCTTRPVLLGGKIPLPAGTYVGYNAYATNR
DQEFWGADADEFKPERWGQTAEDINTMFRKANAKGAFISFHGGRRVCLGQKFAMFEARITMAAVLRSVEWKIDPAWPRMM
TPVSNKIQSHDATDINSVGIDRLGHCIREICESDSSGSARNIPNGTMLIYPNSTGTDRQYHARSERAIPKSNRPAPAGRE
EALNLENAPCLDSSAMFIDHSSALATCASKCCVPVSLNTAAQPLP
>CYP56B3 Coccidioides immitis
80% to CYP56B2 Uncinocarpus reesii
CIMG_00523.2
MAGLLSSLSSVTLVAVAAITVILFLALVYFFIPPASFPRNIPAIPFYYALLPLVKDGDQEALYHTYLEPLFEQHGAAKIF
FGGRWNILVQRPSYIAEVFKYEDTYAKSGNQKKIPYSVLAEYTGDNIISSHGENWKLYRSILQPPLQQDQDPGPIWRNSR
LLISLLLEEQKTSPHGSVLLPQLLQRFTLANLSEGLLGTSFQTLQQKDAALHKFQMMLKPLIFDPVFLNFPFLDHFNFPS
RQRARRLARQFANELCQTVQRGHQHAHTDKSTSNVGCSVIGAFEQGILSEKQFRNNMVSVFLAGHENPQLLLVSMMFLLG
EHQEIQERVREEVLSLGEDELPYSVLQSAPFLTSVIYETLRMYPPISQLINRRTTKPVLLGGKIPLPAGTYIGYNAYATN
RDKQSWGADADEFKPERWGRTVDEINVTFRKANAKGAFISFHGGRRACLGQKFAMFEARIAMAEILRSLRWKIDPTWPRR
MTPVSGLNQNHDAMDEN
>CYP56C1 Aspergillus oryzae
AP007164.1c
third P450 of six on this accession
CDS
join(1160825..1161472,1161531..1162415,1162505..1162558)
47% to CYP56B1 AN2706.1 Aspergillus nidulans
41% to CYP56A1
MVMHGLCIIIGKALAVGILFLSICIFSRIVPPRYPRNIPAVPFW
VTLLSLVRDIDQEDIYRRHIQKPLQTHGAIKIFFAGQWNLLIQRSSYLNEIFRNEDVY
QKSGNQKKIPHSVLAEFL (1?)
GDNVISSRGTTWRLYRDIITPG
LQGHFDAGLIAANAEELCSSLLAFQNTVGNCGVPVQDLLQQFTIANVSQVLLQANHKP
TKGDESSLHQLQLAVKREIFKPIFMNFPVLDRLGKLIPCRVRARNVVEQFSAALQYGV
RHGQGTPNASNLGARLMAARDGGVLTGKQFRDNLNVLFVAGQENPQLLLISMLYLLAKHP
(0)
DVQSRLRREIDACSTLDPSNVAFSELPYVTCVIYESLRLLP
PISQLINRRTSQDVILGNQIYIPKGTYVGYNCYSTNRDPAVWGPTADEFRPERWGQSN
TEISQCYRQRRARAEFVSFHGGSRACLGEKFALLEARVALFVLVSRLSWSLDPEWPDR
KTPAGPLYPRALRLIFTERK
>CYP56C1 Aspergillus flavus
98% to CYP56C1 Aspergillus oryzae
AFL2G_06061
MTLLRITPAKSKRLRVLVGPMRSSVNPASILWHPRGHKRSVFFPKSEQPTSRKMVMHGLCIIIGKALAVGILFLSICIFS
RIVPPRFPRNIPAVPFWVTLLSLVRDIDQEDIYRRHIQKPLQTHGAIKIFFAGQWNLLIQRSSYLNEIFRNEDVYQKSGN
QKKIPHSVLAEFL (1)
GDNVISSRGTTWRLYRDIITPGLQGHFDAGLIAANAEELCSSLLAFQNT
VGNCGVPVQNLLQQFTIANVSQVLLQANHKPTKGDESSLHQLQLAVKREIFKPIFMNFPVLDRLGKLIPCRVRARNVVEQ
FSAALQYGVRHGQGTPNASNLGARLMAARDGGVLTGKQFRDNLNVLFVAGQENPQLLLISMLYLLAKHPDVQSRLRREID
ACSTLDPSNVAFSELPYLTCVIYESLRLLSPISQLINRRTSQDVILGNQIYIPKGTYVGYNCYSTNRDPAVWGPTADEFR
PERWGQSNTEISQCYRQRRARAEFVSFHGGSRACLGEKFALLEARVALFVLVSRLSWSLDPEWPDRKTPVGPLYPRALRL
IFTERK*
>CYP56C2 Uncinocarpus reesii
60% to CYP56C1 Aspergillus oryzae
UREG_04911.1
MFSGALIAMLSKVLLAGVVVLTLSLYWVLVPPRHPRNIPAVPFWVTLLPLFFDVDQENTYRRYIRKPLQQYGVIKIFFGG
QWNLVIQRPTYVAEMFKHEEVYQKSGNQKKIPHSVLAEFLGDNIISSRGDDWKLYRNIIKPGLQKTFETQPIVANARKLC
SLLKKSQQALGSQGILIQNHIQCYTTANISKCVLQAEIESLSTENDTLMKLQLAVKREIFKPIFMNFPLLDRFGSFIPSR
AHARELVRRFSSELESRLVRDHTEMPDSEASDNVGSRLIAARDRGELTQQQFRDNLNVTFVAGQENPQLLLISTMYLLGK
YPEVQCRLRSEIEGCGADEPSHLILRDMPYLTSVTYESLRLFPPISQLINRRVAKPVVLGGEIYIPQNTYVGYNCYATNR
DPTVWGKTADEFRPERWGSTTKEISMRYRVARARAEFTSFHGGSRACLGETFALLEMKLSLFILLKNLSWRLDPKWEDRK
TPVRNLPRPLF
>CYP56C3 Aspergillus clavatus
53% to CYP56C2
ACLA_064250
MDVFFSEWSKTATGWSLLLFLGALPCLFGLYLCFVAPPRHPQQIPSVPFWVTLLPFFFDVDQQETFQQYIAKPLQTHGAI
KMFFAGRWNVIVQRPAMLAEIFRNEHIYHKSGNQEKIPHSVLAEYL
(1)
GSNIISARGDEW
RRYRAVIQPGLQTSFDSSAVFRHAQRLSAVLLGLQERNRRQGVPVQGVLQRYSSANLLRCVLGLSDLSMIKMDQDAPLHS
IQTSLKRYLFQPIFLNFPVLDWLGWAIPSRRQARNLIQDFSTELQMQIVQAHPPGSSTTSVGGRLATAWRDGTLTTQQFR
DNLNVLYVAGHENPQLLLTSALYLLGKFPKVQERLRAEIEQYGTIDEGDTPTVSWERLPYLSATILECARLFPPISQLIN
RRVATPTWLAGNLHLTPGMYVGYHSYATNRDPTTWGPDADEFRPERWGHTHEQIFAAYRRAKARAEFITFHGGPRACLGE
KFALLQMRVSLLVLVRSLSWTLDPEWTDQMMPAGPLHPRGLRLMFITHDKDAAT*
>CYP56D1 Clavispora lusitaniae ATCC 42720 = Candida lusitaniae
AAFT01000066.1, CLUG_02306.1
46% to CYP56A1
MLIDIIISNISVSFWCLCFFFLSWKIFRIIYPPFDFPKNIPTIPFYAAFVSSFLGWDQNK
VYAHYYRENLEKYGAAKIYFASRWNILVTKPEYLAQIFKQNEIFEKSGNQHKIPYSLLAE
YTGDNIISTGNKYWKLYRKAVTNSIQFPNLEPLQTNATVLIENLSAASDNGYFPIADILQ
AYTLNNVGDCVIGTNFHKSDNFDISTSLKKVKQEIFRPLFLNFPLLDLLPFPSRIRARKL
VRSFKRNYCNKILNELNEENKGRLGHNLATFWKQGDITEKQFQDNAMIAMIAGHENPQLL
LTSLIYVIAKYPEIQRQLRSEMNSSNYDVKEQIPLLKAVVYETIRLFPPLGLIVNRKTRK
NVILGNGIFIPKGTYVGYNNFGTQRDRNYWGDDADAFRPERWGNDGKKIEEKYAEAKSKC
TLPAFHGRSRACLGEKFALAEVRKAVIEILQNFEISLDPSWKEQLTPAGPICPLKLSVML
KKVCSEHEHNI*
>CYP56E1 Candida tropicalis MYA-3404
AAFN01000070.1
45% to CYP56A1
MIMFDIVKYTLIGLFSYLLYVILDIVLPPFNFPKNIPTIPFYVSFLGAYTNLDQRDI
YNLYLREKLEKYGAVKIYFASRWNILITRPEYLLEMFRNEDVYSKRGNHLKIPGSVMATY
TGDNIISAHGELWKLYREVIAKSIQFPDFEPITKNTKSLLEIIDGMIDSDKNHAIIPITD
LFQKYSLANVTESILGVNFKVLEGDQSIMHQKIKYVKLQIFKPFFLNFPYFDSFPIPSRL
QARKEVINFRNWYGQSIIDKHDPQLPNSAATKLVDGLMQEKLTEKQFLDNAIIVMIAGHE
NPLLLMLSLMFVAAKYPKVQEAIRSEIDPTKPYLHSVIYETLRMYPPLGLIINRYTTRPT
KLGNIVIPKGVYCGYNNFGTGRDRNVWGPDSDEFKPERWGRDNIEEINRNYANAKRSAEL
PAFHGRKRACLGEKYALYEVKELLTSILGHYKVTLDASWKEKITPAGPISPFGLKVKFEK
LIVA*
>CYP56E2 Candida albicans SC5314
AACQ01000054.1 chromosome R Ctg19-20053, whole genome
45% to CYP56A1 missing N-term runs off the end of the
contig
whole seq on orf19_554
MFQLLKYIFIGGFTYLLYLILEIVFPPFNFPRNIPTIPFYVSFLGACTNLDQE
DIYKLYLREKLEKYGAVKMYFASRWNILITKP
151305
DFLLEMFKNEDVFAKSGNHVKIPNSVLATYTGDNIISAHGELWKLYRDVVAQSIQFPDLK 151126
151125
PISKNTQKLLRFLDNEMGSANQATISVTDILQKYSLANVCESVLGVNFNVLDDKQSLMHE 150946
150945 KIKYVKSQIFNPIFLNFPYFDNFPIPSRLKARREVIGFRKWYGQSLIEKYNLQLPN 150778
150777
SAATKLVDSLIKEKLTEKQFLDNAIILMIAGHENPLLLMLSLLYVVSKYPQVQELIRNE 150601
150600
TETTKPYLHSVIYETLRMYPPLGLIINRCTTRITKLGNIVIPKNVYCGYNN 150448
150447
FGTGRDRNVWGSDADIFKPERWGLEIDEINKKFTLAKRSAELPAFHGRKRACLGEKYALF 150268
150267
EVKQFLLAILGEYKVSLDPNWKEQLTPAGPISPLRLKLNFEKLTVS* 150127
>CYP56E3 Candida dublinensis
96% CYP56E2 Candida albicans (ortholog)
cdub_14-g334.1
MLQLLKYIFIGGFTYLLYLILEIVFPPFNFPRNIPTIPFYVSFLGACTSLDQEDIYKLYLREKLEKYGAVKMYFASRWNI
LITKPDFLLEMFKNEDVFAKSGNHVKIPNSVLATYTGDNIISAHGELWKLYRDVVAQSIQFPDLKPIFKNTHKLLRFINN
EMGSANQTTISVTDILQKYSLANVCESVLGVNFNVLDDKQSLMHEKIKYVKLQIFNPIFLNFPYFDNFPIPSRLKARREV
IGFRKWYGQSLVEKYNLQLPNSAATKLVDSLIKEKLTEKQFLDNAIILMIAGHENPLLLMLSLLYVVSKYPQVQELIRNE
TEPTKPYFHSVIYETLRMYPPLGLIINRCTTRITKLGNIVIPKNVYCGYNNFGTGRDRNVWGSDADTFKPERWGVEIDEI
NKKFTLAKRSAELPAFHGRKRACLGEKYALFEVKQFLLAILGDYKVSLDPTWKEQLTAAGPISPLQLKIKFEKLTVS
>CYP56E4 Candida parapsilosis
65% to CYP56E1 Candida tropicalis
CPAG_05515
MINSLKGILWFRFVHNGTMVMFEFIKVVAASLLGFGLYLLLEIVFPPLCFPRSIPTIPFYVSFLSSWTNLDQRDIYNTYL
REKLEKYGAVKIYFASRWNILVTRPEYLIQVFKHEDIYAKSGNHLKIPGSVLASYTGDNVISAHGPLWKLYREVVSSSIQ
FPDLSTIHQNTNKFLDLLEQDLSTKSSILVNDLLQRYTLANVGDSILGVDFKALDGKESIMHQKIKYIKQQIFKPFFMNF
PYIENFPIPSRIKAKREVEGFRNWFGQNLSSNYNPERGNSAATKLAQALCNEKLTQKQFLDNAIIIMVAGHENPLLLMLS
LLFVVAKYQDVQELVRSETNPEQPFLCSVIYETLRLFPPLGQIINRCTTSSVCLGDIRIPRGVYVGYNNMATGRDRSVWG
ADADQFKPSRWGTTISEINTNYSSSKRLAKLPAFHGRKRACLGEKFALHESKLLLTSVLEKYKVSLDENWQEKITSAGPV
GPLGMKLKFEKV
>CYP56E5 Lodderomyces elongisporus
runs of EE probably in an intron seq
59% to CYP56E2 Candida albicans
LELG_03266
MIVLFITILLVLSALIVFPPLNFPRNIPTIPFYVSFLGGMDQLEKFEKYLRTKLEKHGAVKIYFASRWNILVTKPEYLVH
IFKNEDVFAKSGNHIKIPGSVLATYTGDNIISAHGQLWRLYRDVMAQSIQFPNLDPIAENTNNLMKDLENALKFDSSVAI
TDFLQQYSLANVGDCIVGSNLRPMHQKIKYIKLQIFKPFYMNFPSVEMLPIPSRIRAKQEVENFRQWFGDKLMDADHGAA
VKLATAYNEGKLTQKQYLDNCIILMVAGHENPLLLMLSLLYVLAKNPYMQDKIRCNKE
IEEHGKEEGGRVVEEEGEEGEEEEGEEEEEEEEEEEEEEEEK
SPELYLSAVIYETLRMYPPLNQIINRCTTKDTMLGNIRIPKGTYVGYYNMGTGRDKTVWE
SPDTFWPERWGNTIEEVHANYTRAKRLGHLPAFHGRKRACLGEKFALYQCKAMVQAILGKYKISLDEDWEERITPAGPVC
PMNMKLRFSKI
>CYP56E6 Pichia stipitis
57% to CYP56E4 Candida parapsilosis
JGI model e_gwh1.2.1.1913.1
MISALIVGVLLIVKSIILPPSNFPKSIPTIPFYVSFLGAYTSMDQEEIYNYYMREKLEKYGAAKLYFASRWNIVIIEPEL
LLQLFKNENIYAKSGNQEKIPYSVLAQYTGENIISAHGEKWRLYRRVVASSVQFPNMEPIVENSKRFLDVLHQELINNSP
IEIIDLLQRYTLANIGDSVLGVKFNTMEEKDTEIHKRIKHVKRQIFQPLYMNFPFLDKLPIASRMEARKEVAQFRSYFSN
ILKTCQNFGRETGASRLRQALDNNTLTEKEFTDNGIILMVAGHENPLLLLLSLFYIVAKYPEVQHKIRQENGDNEAPYLN
SVICECLRMLPPLGQIINRRTTENVILGSNIRIPKGTYVGYNNFGTGRHRKIWGESADEFKPERWGKTPQEISRKYLEAK
IKANLPAFHGRKRACLGEKFALEEVRVLIQTLLQMYQLLLDPNWVEKITPAGPICPLGLKIKFKKIEF
>CYP57A1v1
Nectria haematococca L20976
MLVDTGLGLISELQAKLGWAVLLQIVPITIVAYNLLWFIYASFF
SSLRKIPGPFLARISRVWEMKKTATGNIHEIMMDLHRRHGAIVRIGPRRYDFDTMEAL
KIIYRIGNALPKADYYKPFGLPSFPNLFDEQNPARHSAIKKQVASLYTMTALLSYEEG
VDGQTAILKEQLQRFCDQKQVIDLPRFLQYYAFDVIGVITVGKSMGMMESNSDTNGAC
SALDGMWHYASMMAYIPNMHAWWLRLSSLLPIEVPIKGLTEYVERRIIQYRLKAAEFG
DDAALKGENNFLAKLLLMEKKGTVTPVETQQAVGLNIGAGSDTTANALSTILYYLYTN
PRTLHTLREELERYVKDGPISFQQSQSMPYLQAVIKEALRLHPGVGTQLTRVVPKGGL
VIEGQFFPEGTEVGVNGWALYHNKAIFGNDASIFRPERWLEANENINIGGSFAFGAGS
RSCIGKNISILEMSKAIPQIVRNFDIEINHGDMTWKNECWWFVKPEYKAMIKPRRCCL
SRDESLV
>CYP57A2
Nectria haematococca X73145
MLVDTGLGLISELRARLGWAALLQIVPVTVVAYNLLWFIYTSFF
SSLRKIPGPFLARISRVWEIKKAATGNIHEIVMDLHRCHGPIVRIGPNRYDFDTMEAL
KIIYRIGNALPKADYYIPFGLPSSPNLFDVQNPARHSAMKKQVASLYTMTALLSYEAG
VDGQTIILKEQLQRFCDQKQVIDLPQFLQYYAFDVIGVITVGKSMGMMETNSDTNGAC
GALDAMWHYSSMMAFIPHMHAWWLRLSSLLPIDVPIKGLTEYVEQRIIQYRLKAAEFG
DDDALKGENNFLAKLILMERQGTVTSTETQQAVGLNIGAGSDTTANALSSILYFLYTN
PRTLRRLREELDTHVKEDPIRFQQSQSMPYLQAVIKEALRLHPGVGTQLTRVVPKGGL
VIEGQFFPEGAEVGVNGWALYHNKAIFGNDASVFRPERWLETKGNLNIGGSFAFGAGS
RSCIGKNISILEMSKAIPQIVRNFDIEINHGDMTWKNECWWFVKPEYKAMIKPRAA
>CYP57A3 Nectria haematococca
fgenesh1_pg.scaffold_15000311
Necha1/scaffold_15:835216-837380
61% to fgenesh1_pg.scaffold_36000065 CYP57A1,
MLIDAIRLKMWELYSSRSLSDLNNLLLLGQ
ICYTIVWLFHAFFLSSLRKLPGPFLARLTRLWEVRKVTTGDIHDIMIDLHETH
(1)
GPIVRIAPNRYDFNTPEAVKIIYRIGNAFHKSHFYDPFGSPQFKNLL
NELDNSRHAAMRRQLASLYTMSTLMSYESAVDGQTLILREKLLKFCDQGEVIDVPQFLQFYAFDVIGVIT
(0)
VGESMGMMESNTDMHGACRDLDAIWRYAAVVGLLPSLHPWVVRISSFLRLRGVSDGLDSFVDAQIRQYKE
KQGSPDANTNEDTTFLSAMLKLERQGKATEAETRLCLSMNIGAGSDTTAISLSSIIYYVYTNPRTLRHLR
EELERATREGRLSDPIKFQEAQELPYLQAVIKEALRLHPGVGTQLTRIVPKGGVVIEGQYFPEG
(0)
VEVGVNAYALYHNQDVFGKNASSFQPERWLESESEGIRIAGSFA (0)
FGAGPRSCIGKNISILEMSKAIPQIVQHFDIELEPRDKPWDNECWWFVKPQYKARIRRRTS*
>CYP57A4 Nectria haematococca
fgenesh1_pg.scaffold_30000136
Necha1/scaffold_30:357529-359333
63% to fgenesh1_pg.scaffold_15000311, 57% to
57A1
This gene model seems correct DRN 2/5/06
MLVNSGFGITLAELHGSQALAILVKIFVAGYAFYIILWLVYILFLSNLRKVPGPFLAKLTRLWEVKKVIT
GNIHGIMIDLHKIH (1)
GPIVQIAPNRYDFNTPEAVKTIYRIGNAFTKSRYYEPFGDPSFHNLMNALDNKDHAALR
KQIASLYTMSALLSYEPLVDAQTTILKEKMEGFANRGDVVDLPLFLQFYAFDVVATIT
(0)
IGKSMGMMESNTDMYDTCQVLDGMWHYIAVSGLIPGIHLRYIQLAKLLGLTPPTKALDFFIDTQIQHYTE
AMERKGGVGDDEDTFLARMLKLQEQGKATKKDTRHCVTINIGAGSGTTAIGLSSVIYHLYSNPHALNRLR
EELDEFVKAGELSDPVGFQQTQKMPYLQAVTKEALRLHPGVGTQLTRVVPKGGVVIEGQFFPEG
(0)
AEVGVNGWALYYNQDVFGDDAAKFRPERWLQPGEDVRIAASFA (0)
FGAGPRSCLGKNVSILEMSKAIPQIVKNFDIEIQYESWKHESWFFVKPEFKAQIKLRVR*
>CYP57B1 Nectria haematococca
gw1.57.27.1
43% to fgenesh1_pg.scaffold_15000311, in CYP57 family, model short at N-TERM
Necha1/scaffold_57:81298-82977
MALLRNLESSPIAQYVLSRLQHAGLKDLAAAFLLTSATLITVLYLVPLVYSLFFSPLRKIPGPLLTRVTH*
WEYRVVIKGDSNREYIRLHKKY (1)
GPVVRVGPNRYSVSQPKDIKTIYELGGKFTKSDYYKPLLNPNPEEQNIFPIQDNERHKERRRRISPLYTISSMVSY
EPAVDDITAVCMRKLYQFAEEGRLLDIPHWMQYYAFNIIGEIT (0)
FNKSFNMIENEGDTTGMIPGIREANDF
LAYLGVIPSLVPWVIGLSAVLGRKSNTSVLVSYTFAQINKNQEANAHSTTKDSKKYNTFLKKVLDMKSQG
RLKLPNVLDACGSNIGAGSDTTAVTLSSTLFFLYSNPNKLAKLRREIDTKAADGSISDPVTFQEAQNMTY
LQAVIKETLRLHPAVGTILPRVVPRGGIELSGHYFPEG (0)
TEVGVNAWVLHYSKDIYGPDPEVFRPERWIGDEKTSIMDSMMFA (0)
FGAGSRTYIGRNISLLELTKVVPQIVRKFDLEFELPGKPMDTTCAWFVYPHYNGRFKIRETKA*
>CYP57B2 Nectria haematococca
complete joined model 45% to 57A2, 83% to
gw1.57.27.1
MALLQDLQSSLIAQRILSSLQHVSPKDVAIGFLLTAAVLYIFFYLIPLIYSLFFSPLRKIPGPLLARVTR
WWEYRLVSKGDSNLEYIRLHQKY (1)
GPVVRVGPNRYSISQPKDVKTIYELGGKFTKADYYKPLLNPDPEKQN
IFVVLDNDRHKEKRRKISPLYTMSSMVSYEPAVDEMTTVCIRKLYQFAKEGRLIDIPHWM
QYYAFDVIGEIT (0)
FNKSFGMMENEGDTTGMIPGIRAANDFLAYLGIIPNLVPWVLGLSAVLGRKSNTSVLVSYAFAQIDRNREANVHST
TKDTKKYDTFLKKLLDMEAQGRLKLPNVLDACGSNIGAGSDTTAVTLSSTLYFLFRNPDKLDKLRQEIDT
KTAEGSISDPVTFREAQDMSYLQAVIKETLRLHPAVGTMLPRVVPRGGMELSGYYFPEG
(0)
TEVGANAWVLHYSKDIYGPDPEVFRPERWIGKEKTSIMDSMMFA (0)
FGAGSRTCIGRNISLLELTKVVPQIVRKFDLELEHPDKPMDTTCAWFVYPHYNGRFKVRGAKASD*
>CYP57B3
Aspergillus oryzae
GenEMBL
BAE55311.1
56% to 57B2,
55% to 57B1
MIGTVLDTVLGNPQGAVGGLFVGSFVIFWVVPFLYNLFFSPLRNVPGPFWARFTILWEFSQLMKGRSHEE
YIKLHKKYGPVVRVSPKRYSVIDPQDVKKIYGFGADFPKSEFYDSLGDPKNIFTVRDNEDHKDRRRKVAS
LYTMSSMVAYEDAVDRMTTLCIKKMTDLAASRKLISIPKFMQFYAFDVIGEITFDQNFGMMENMGDTQGI
IKEIHAMNNTIGIMGLLPELQSTWRAAQKVLFSGTAMGKLTEYIWSQYWKHRNTNSGAKQKSQYDTFLRK
VLELEAAHKVGRMNVLDSCGSNIGAGSDTTGITLSAALWYIYRNPDKLAKLRHEIDTMTAEGRISDPVTY
KQAQEMPYLNAVIKETLRVHPGVGTILARVVPKGGITLTGGYYVPEGTHIGTNAWPLHYSETVYGPDADQ
YRPERWLEDKPQPDYRDSMMFAFGSGSRTCIGRNISLLEITKVLPQIVRKFDLKFEEKKDPWDAW
CAWFVYPKYKCWIEPRKPVENVA
>CYP57B3 Aspergillus
flavus
100% to CYP57B3
Aspergillus oryzae
AFL2G_00227 revised
MIGTVLDTVLGNPQGAVGGLFVGSFVIFWVVP FLYNLFFSPLRNVPGPFWARFTILWEFSQLMKGRSHEEYIKLHKKYGP
VVRVSPKRYSVIDPQDVKKIYGFGADFPKSEFYDSLGDPKNIFTVRDNEDHKDRRRKVASLYTMSSMVAYEDAVDRMTTL
CIKKMTDLAASRKLISIPKFMQFYAFDVIGEITFDQNFGMMENMGDTQGIIKEIHAMNNTIGIMGLLPELQSTWRAAQKV
LFSGTAMGKLTEYIWSQYWKHRNTNSGAKQKSQYDTFLRKVLELEAAHKVGRMNVLDSCGSNIGAGSDTTGITLSAALWY
IYRNPDKLAKLRHEIDTMTAEGRISDPVTYKQAQEMPYLNAVIKETLRVHPGVGTILARVVPKGGITLTGGYYVPEGTHI
GTNAWPLHYSETVYGPDADQYRPERWLEDKPQPDYRDSMMFAFGSGSRTCIGRNISLLEITKVLPQIVRKFDLKFEEKKD
PWDAWCAWFVYPKYKCWIEPRKPVENVA
>CYP57B4 Fusarium oxysporum
81% to CYP57B2
FOXG_01386
MAFLRDAESNPTVQAIFSRLKHVDATAVAAGLPLNTFRSCLFILLHRITL
(sequence gap)
KLNQFAKEGRLVDIPHW
MQYYAFDVIGAITFNKSFNMMENEGDTTGMIKGIREANDFLAFWGIVPNLVPWLIGIATALGMTSNTSTLVSYALKQIDN
TRKENAKSTVKGTTKYDTFLKKLLEGESEGRLKTPNLLDACGSNIGAGSDTTAVTLSSALYYLFQNPDKLKKLREEIDQK
AAHGGLSDPVTFQEAQDMPYLQAVIKETLRIHPAVGTILPRVVPRDGMELSGIYFPEGTEVGVNAWVLHYDKGIYGPDPE
VFRPERWLGDEKTSIMDSMMFAFGAGARTCIGRNISLLELTKMVPQIVRKFDLVIEDADKPLDTFCAWFVYPHYNGRFKV
RE*
>CYP57C1 Mycosphaerella fijiensis
51% to CYP57B3 Aspergillus oryzae
fgenesh1_pg.C_scaffold_2000556 revised N-term
MPSFEIQHSVLANLSAKQILALTSILLGITIAYQFVYALLLSPVKDV
PGPFLARFTRLWELRQMLRGEFHETIVKLHKQHGPIVRISPNLYSLNSPADQKKIYNLRADLSKTPYY
DAGGHPQRPNLFSTQDASLHADRKKPVANLYSMSSMVHYEDAVDRMIKICLRKFAGFAEKRKKVFVPKFMQAYAFDVIGE
ITINQNFGMMETEADVDGMMELVHASIRYLGTVGIFPEFHSWIFRIVSFLRLRHAGGLIEKIASDTIRKFRHPDRMIEKE
DPNSDPFISKLLRLEAAGKADSSHLMDAIASNIAAGSDTTAITLSAALYYLYRTPRALAALRKEIDEMQKAGKISDPVSF
KEAQDMPYLQAVILETLRLHPAVGYVLPRKVPAGGMELAGRHLPGGTCVGVSAWALHRNPEAYGDDASEFRPERFLVSED
SSSKNRTASLASSFAFGGGTRSCIGKNISLLEMTKAVPQIVRKFDLVFESDEPWELFSTWFVWQKYHCYIEPRKG
>CYP58A1
Fusarium sporotrichioides U22462, ALSO U10456 mini chromosome
ESTs BI191705 BI191704 BI191231 BI200306
BI201084
Formerly CYP579A1
MVDQDWIKALVNIPISHAVGVVAASTVIYFLSSCFYNLYLHPLR
KIPGPKLAAIGPYLEFYHEVIRDGQYLWEIAKMHDKYGPIVRVNDKEVHIRDPSYYST
IYTAGARKTNKDPATVGAFDVPTATAATVDHDHHRARRGYLNPYFSKRSITNLEPFIH
ERVTKLLSRFQEHLDNDQVLSLDGAFCALTADVITSRFYGKHYNYLDLPDFHFVVRDG
FLGLTKVYHLARFIPVLVTVLKRLPYSCLRLIAPSVSDLLQMRNEIHERGGDEFLSSK
TSEAKSSILFGALADTHIPPVERTVERMLDEGTVILFAGTETTSRTLAITFFYLLTHP
ECLRKLREELNSLPKVEGDRFPLATLENLPYLNGVVHEGFRLACGPISRSGRVATQEN
LKYKEHVIPAGTPVSQSTYFMHTDPKIFPEPEKFKPERWIEAAEKKIPLKKYITNFSQ
GSRQCIGYTMAFAEMYLAMSRIARAYDVELYDTTKADIDMTHARIVAYPKAIPGKTEH
VGEIRVKVLKAL
>CYP58A2 Myrothecium roridum AF009417
65% identical to 58A1 Fusarium sporotrichioides
MAVLNFETVSNAIPLGAVAGGIAGLYFLYLAWNCFYNIYLHPLS
HIPGDKLAVMGPYLEFYHEVIRGGQYLWEVEKMHERYGPIVRVNAREVHVKDSSFYHT
IYTAGSRKTNKDPSAVGAFDVPSSTAATIDHDTHRARRGYLNPYFSKRSLASLEPTIN
ERIGKLAERMNGHMNGKEILTLDGIFSALTADIICSRFYGKNFDYLSVPDYHFVVRDG
FQGLTKLYHLARFLPTMVNGLKVLPEWFVRMFLPPLADLMVMRQEIHTNGAEMFTNSH
TADSKASALVGALADTNIPVHERTISRLLDEGTVFLFAGTETTSRTMAITMFYLLSNP
DCLRKMREELDTLPASEGFAHSLQTLEALPYLSGVVNEGLRLAFGPITRSARVPMNVD
LQYQDYTIPAGTPLSMSTYFVHTDEELYPDPMAFKPERWIKAAEDGVPLKKFLTNFSQ
GSRQCIGINMSFAEMYLTLSRVAREFDFELYDTTMADLDLTYARIVGYPKAIPGKTEG
TGEIRVKVLNRHSPNFEKQELISTA
>CYP58A3 Fusarium graminearum old name =
CYP579A2 FG03535.1 AACM01000159 FGcontig1.159_scaffold2
MIDQDWIKSLLNIPVSHVAGIFAASTVIYFLSSCFYNLYLHPLRKIPGPK
LAAIGPYLEFYHEVIRDGQYLWEISKMHDKYGPIVRVNAREVHIRDSSYY
TTIYTAGSRKTNKDPATVGAFDVPSATAATVDHDHHRSRRGYLNPYFSKR
TITNLEPFIHERVTKLLTRFQQHLDDDQVLSLDGAFCALTADVITNRFYG
KHNDYLSLPDFHFVVRDGFLGLTKIYHLARFLPGLVTILKRLPYSCIRMI
APSVCDLLQMRDEIQDRGGEEFLSNKSHEAKSSILFGALADSHIPSHERT
VERMLDEGTVILFAGTETTSRTLAITVLYLLTHPECLKKLREELNSLPPV
KDGQYSLATLENLPYLNGVIHEGFRLAFGPISRSGRVATQENLKYKEHVI
PKGTPISQSTYFMHTDPKNFPEPEKFKPERWIEAQQKGIPLKKYITNFSQ
GSRQCIGYTMAFAEMYLALSRIARAYDIELYDTTKADIDMTHARIVGYPK
AIPGKKEHLGEVRVKVLKAL*
>CYP58B1 Aspergillus parasiticus
AY371490.1
aflatoxin pathway gene
93%
to CYP58B2P Aspergillus flavus NRRL3357
MASNTVYTSLIGLLVALTVRSIYRVYFHPLRKIPG
PKIAAITHLYQHYYDAVKGGKYIWKLDELHRKY
(1)
GPIVRFNPNEVHIQDSHYYHHIYAGGAKKQDKDPGFPAVPLFPGVTVTTIKH
NHHRLRRGIIKSFFSKQYVTGLEHVIQSKVNLLASRFTEAYRHGTVLDLKYVFAALTSDL
TTHYVYGTNLNHLAEPDFKNDFLAGMDSVGPWIPVLLVFGRLLKLARYLPACLVPAGEFL
HLWTLSERRVGEILDSQDNGTMGDQKTLLQAMATADVSEEEKTATRLQMETLNIIAGGTE
TTARALAVGVFHLAHKPSLLLQLRDELRTVMPFPDSLASCTQLEQLPYL
(0)
AGVVNESLRLSFGFIIRSARVYPNDPLVYEDLVIPPG
(0)
TPISQSAYFVCMDPSIFPQPEDFNPDRWVQAAREGNNLHRYLIVFSKGSRHCLGIN
(2)
FALAEIYLAIATIARRFDLVPYQTTVEQLQMKRDLGFAAPEKGPFTVRAKVTGLAD*
>CYP58B2P Aspergillus oryzae
Supercontig 10: 19609-20001 +
95% to CYP58B2P Aspergillus flavus
even
pseudogenes are well conserved
TVTTIKHNHHRLRRGIIKSFFLKKYVTGLEHVVQNEVNLLASRFTEAYHHGTVLDLKY
VFAALTSDLTTHYVYGTNLNHLAEPDF &
KNDFLAGMDSVDPWIPVLLVFGRLLKLAGYFPACLVSAGEFLHLWT &
LSERRVGEILDSQDNGTMGDQKTLLQAMATADIPEEEKTATRLQVETLNIIAGGTET
TARALAVGVFHLAHKPSLLLQLRDELRTVMPFPDSLASCTQLEQLPYSYL (0)
AGVVNESLRLAFGFIIRSARVYPNDPLVYEDLVIQFP (?)
TPISQSAYFVCMDPSIFPQPDDFNPDRWVQAARDGNKLHRYLIVFNKGSR
HCLGIN (2)
FALAEIYLAIATVARRFDLVPYQTTVEQLQM
KRDLGFTAPEKGPFTVRAKVTGLAD*
>CYP58B2P
Aspergillus flavus NRRL3357 pseudogene
AAIH01000612.1
missing
first 29 aa, two frameshifts and one stop codon, bad boundary at 1273
AFL2G_07229
76 LRKIAGPKIAPITHLY*HYYDAVKGGKYIWKLDELHRKY (1) 192
255 GPIVRFNPNEVHIQDSHYYHHIYAGGAKKQDKDPEFPAVPLFPGV TVTTIKHNHHRLRRG 434
435 IIKSFFSKKYVTGLEYVIQSEVNLLASRFTEAYHHGTVLDLKYVFAALTSDLTTHYVYGTNLKX 623
626
LAEPDFKNDFLAGMDSVDPWIPVLLVFGRLLKLAGYLPACLVSAGEFLHLWT 781
783
LSERRVGEILDPQDNGTMGDQKTLLQAMATADVPEEEKTATRLQMETLNIIAGGTETTARALAV 974
975
GVFHLAHKPSLLLQLRDELRTVMPFPDSLASCTQLEQLPYSYL (0) 1103
1163 AGVVNESLRLAFGFIIRPARVYPNDPLVNEDLVIPFP (?) 1273
1362
TPISQSAYFVCMDPSIFSQPDDFNPDRWVQAARDGNKLHRYLIVLSKGSRHCLGIN (2) 1529
1599
FALAEIYLAIATVARRFDLVPYQTTVEQLQMKRDLGFTAPEKGPFTVRAKVTGLAD* 1769
>CYP58B3 Aspergillus nomius isolate AN13137
AY510454.1
8295-10054
92% to CYP58B1 Aspergillus parasiticus
gene CypA of aflatoxin biosynthesis
gene model revised
MVSKTVSTALIGLLVALILRSVYRVFFHPLRKIPGPKIAAITHL
YQHYYDAVQGGKYIWKLDELHRKYGPVIRFNPNEVHIQDSHYYHQIYAGGAKKQDKDP
GFPAVPLFPEVTVTTIKHHHHRLRRGIIKSFFSKQYVMGLEHVIQSKVNLLASRLTEA
YRHDTVLDLKYVFAALTSDLTTHYVYGTNLSHLTEPDFKNDFLAGMDSVGRWIPVLLV
FGRLLKLARYLPACLVPAGEFLHLWTLSERRVGEILGSKNNGTMGDRKTLLQAMATAD
VPEQEKTATRLQMETLNIIAGGTETTARALAVGVFHLANKPSLLLQLRDELRTVMPFP
DSTASWTQLEQLPFL
(0)
AGVVNESLRLSFGFIIRSARVYPNDPLVYEDLVIPPG (0)
TPISQSAYFVCMDPSIFPHPEDFNPDRWVQA
ACEGHNLHRYMIVFSKGSRHCLGINFALAEIYLAIATVARRFDLVPYQTTVEQLQMKR
DLGFAAPEKGPFTVQAKVTGLAD*
>CYP58C1 Aspergillus nidulans revised
MTVAQWMRWEVPLLLIISFYLTRTVYRLFFHPLTRFPGPKITAATGLYEF
YHDVVRGGKFLWEIEQMHQVY
GPIVRITPWEIH
VKDPHFYDEIYTSARKCNKDPNFVGMFGSPTSMIATVDHGHHRFRRGILS
SFFSKRSIRDISPLIRRKVQRLMERLAEFYQTDTEVDLSAAFAALTADII
STYSYGESFDFLEDGSFHSEVRDAIMETEKLDHISRLFPVVLTVIRHVPV
WAFAIVKPATAVIAGIQKRVAEKSAKALKMTGSSKEEWTMFDALTDPKLP
ACERTMSRIHDEGMILLSGGTEPTANALTVAAFHMINQKDILTTIREEVR
ASGRDVKKASLAELEQLPYLTAVVNEALRLSHGLSIRSPRISPTEALTYK
SYVIPAGTPVGMSNYFVHMDPSIFPHPASFNPNRWIEASKRGEKLDRFIT
AFGKGSRQCIGINLGYAELYFALASFATFFDYQLHDTTEENVRVARDRGV
PFPEAGHLTCLWRMWPSEGMILKAQISPEFRQCLLIVATRKAYARNGSML*
>CYP58D1 Aspergillus nidulans
AACD01000172.1 Aspergillus nidulans FGSC A4 revised
MNRILAVTVSALASASERLTVSIPVLLILGLVVRTIYRLYFDPLHHIPGPKLAAI
THLYEFYHDVIRGGLFIWEIEKMHREY (1)
GPIVRINPREVHIKDSQFYEEIYAPASGGRRDKDRQAVEIFSSPTA
MVATVDHDTHRIRRKLLTFFFSRRSIERLEPVVHESLSKFLDSLVAAYKE
DTVVDLIDRLQGLTGDVITQYAYGNSYGLQEPQNIGRGITKVVQEGTTQI
HLHRFFPFFERLLRVVPKWFMAQMLPARAAIYDLLNGVREQSIEALKQRD
MSAPPPKKTTMFHALTAPEVPPEERTLQRLQDEGLVLFAAGTETTATILG
VALFHILNNKEVHRKLRNELDQELPTPQAGTTWRQLEKLPYLNATIHEAL
RCSGLTMRQQRIAPTEVVKYKNYVIPPGTPVSMISHFVNMDPDIFDDPQT
FKPERWILAAEKKQNLSRFLVTFGKGNRNCIGMNLAYAELYNTLAAVVRR
FDLELYQTTEENVRFVRDMLLPRSTNGPWKVRVKVIGIREE*
>CYP58D2 Aspergillus oryzae RIB40
AP007157.1b genomic DNA, SC023
73% to 58D1
complement(join(191351..191525,191581..191747,
191803..191910,191973..192829,192878..193118))
MGVISVVTFLASAKEHFIISILLLFPIALILRTIYRLYIDPLHH
IPGPKLAAISHLYEFYHDVVRGGLFIWEIEK MHQEY (1)
GPIVRINPREVHIKDPYFYDELYAPAHGWRDKDAKSVEIFSSPNA
LVSTVDHHTHRMRRKLLTSFFSRRSIERIEPVIHE
SLSKFLDSLITAYEEDSVVELIDRLQALTGHVITQYAYGEDYGLHEPQNIGKGIVKVV
QEGTEQIHLHRFFPLIQRFLRLIPSFFMTQLFPARAAMYDLLHGVRKKSIEVLQQKDV
CTPTERTTMFHALTAPEVPPEERTLQRLEDEGLVLFAAGTETTATTLGVAIFHILSDP
MVLTKLRKELEQVMPTPEGLATWRELEKLPYL NGVIHEALRFSGLAMRQQ
RVSPTEVI
KYKDYAIPPGTPVSMLQYFLHTDPALFSDPEKFYPERWMLAAERKESLSRFLVTFGKG
TRSCIGMNLAYAELHTALAAIVRRFDLELYETTAEDIRFVRDKLLPRAKNGPWRVRVK
VVGIRKD
>CYP58D2 Aspergillus flavus
99% to CYP58D2 Aspergillus oryzae
AFL2G_03972
MGVISVVTFLASAKEHFIISILLLFPIALILRTIYRLYIDPLHH
IPGPKLAAISHLYEFYHDVVRGGLFIWEIEKMHQEY
(1)
GPIVRINPREVHIKDPYFYDELYAPAHGWRDKDAKSVEIFSSPTALVSTVDHHTHRMRRKLLTSFFSRRSIERIE
PVIHESISRFLDSLITAYEEDSVVELIDRLQALTGHVITQYAYGEDYGLHEPQNIGKGIVKVVQEGTEQIHLHRFFPLIQ
RFLRLIPSFFMTQLFPARAAMYDLLHGVRKKSIEVLKQKDVCTPTERTTMFHALTAPEVPPEERTLQRLEDEGLVLFAAG
TETTATTLGVAIFHILSDPMVLTKLRKELEQVMPTPEGLATWRELEKLPYL
NGVIHEALRFSGLAMRQQ
RVSPTEVIKYKDYAIPPGTPVSMLQYFLH
TDPALFSDPEKFYPERWMLAAERKESLSRFLVTFGKGTRSCIGMNLAYAELHTALAAIVRRFDLELYETTAEDIRFVRDK
LLPRAKNGPWRVRVKVVGIRKD
>CYP58D3 Aspergillus fumigatus Af293
GenEMBL
XP_753152.1 also AAHF01000003.1
trichodiene
oxygenase predicted
71% to 58D1
N-term and C-term
parts of broken gene
MRRKLLNNFFSRRSIENIEPVIHNSLSRFLDGLTTAYKEGSVVELIDRLQGLTGDVITEYAYGENYGLQD
PENYGKGIVKVVQEGTDQIHFFRFFPLVSQLLRIIPSWFMGQVFPARAAIYQLLDGVRKQSILALQQKNV
STAPQRMTIFQALTAPEVPPEERNLQRLQDEGLVLFAAGTETTATTLAVALFYN
YILNDKRVLSKLRRELEQI
MPTPQHPTTWRELEKLPYLTAVIREALRFSGIVMRQQRISPTEALKYKDIVVPPGTPVSMIARFVHMDPT
IFPDPTRFHPERWMLAAGREEGLSKFLVTFSRGNRGCIGMNLAYAELYNTLAAVVRRFDLELNQTTPENI
RFVRDKLLPRSKDGSWTVRVKVVGIREQ
>CYP58E1 Nectria haematococca
fgenesh1_pg.scaffold_14000019
Necha1/scaffold_14:58063-59829
46% to 58A2 also 48% to 579A2, check 579A2 vs
58A2 = 65%
Note 58A2 and 579A2 are same family and same
subfamily,
already revised names 579A2 = 58A3, not yet
changed on blast server
This gene model seems correct DRN 2/5/06
Note this gene is near scaffold_14000017
MTENVFWIDKPAIAAAGAAGLFWISYLVCEVIYNLFFHPLSKFPGPKIAAIGTYYEFYHDVIRDGTYLWR
IEEMHRKY (1)
GPVVRINADELHIHDPDFYSKVYAGSKRVNKYGPAVAAFTVPRATLATIDHDVHRLRRSILN
PYFSKRAVTMLEPLINDKVDRLCGRLEEWIGQGTPVDLDAAMAALTADIVSIYFYGKDFDYLGGKDFKFV
VRDAILGLIRFYHFSRFVPAVANFINSLPIPIVRMIQPGAAALLESQQEILVEIQQSLNDKDNVKSKSVI
VGALGDPDIPAEEKTLDRLVDEGVTVIFAGTETTARSISVAIFHLLRDKSLLQKLRDELSTVEKGPDGQW
AYNQLEALPYL (0)
TGCVQEGLRLAHGPVIRLPRVSPNEALQYGDWLIPAG (0)
TPVSESTLLVHLDPSIFPNPNTFDPDRWVRAAAEGVHLSKYICSFTKGTRQCLGIN
(2)
LAYAELYIAIAKIATSFEMELYNTSLEDVQVHHIRLTGYPKRGTGEIKATITSKA*
>CYP58E2 Aspergillus oryzae
GenEMBL BAE59845.1
61% TO 58E1, 47%
TO 58A2, 41% to 58C1, 46% TO 58A3
MLDTISESRPNGLATLGVVVATFATYLALKALYNLYLHPLRKFPGPKLAAIGPYYEFYYDVMKDGMFLWE
MERMHQVYGPIVRVNANEIHIRDPHYYSTVYAGNHRSTDKYHDAVAAFSVPQASLATIHHKVHRLRRSIL
NPYFSKAAVTRLESAINERIERMCSRLEETMHYGQVVDLDAGFAALTADIVTTYFYGQNFDYLGNEGFKF
QVRDAILGLIQFYHFTRFFPWIANTIKKLPIPIMRLIHPGAAYLVSSQEEIKDSIRASLDKGNKADAKSV
IVQALEDPTIPPQERTLDRLGDEGTTIIFAGTETTARALSVGMFHILNNKTILKKLREELDTLPGVSSGV
YSHVQLECLPYLTGAVQESLRLSHGPAIRLPRVANDKALKYGDYIIPPGTPVSLCTVLVHQDPCIFPDPH
RFDPERWVKASKEGVNLDKFIAAFTKGTRQCLGINLAYAEIYLTFAKLIRTFNMEIYDTTVDDLTVHHIR
LTGAPKQGTGEVKVKVTEKIL
>CYP58E2 Aspergillus flavus
100% to CYP58E2 Aspergillus oryzae
AFL2G_06877 revised
MLDTISESRPNGLATLGVVVATFATYLALKALYNLYLHPLRKFPGPKLAAIGPYYEFYYDVMKDGMFLWEMERMHQVYGP
IVRVNANEIHIRDPHYYSTVYAGNHRSTDKYHDAVAAFSVPQASLATIHHKVHRLRRSILNPYFSKAAVTRLESAINERI
ERMCSRLEETMHYGQVVDLDAGFAALTADIVTTYFYGQNFDYLGNEGFKFQVRDAILGLIQFYHFTRFFPWIANTIKKLP
IPIMRLIHPGAAYLVSSQEEIKDSIRASLDKGNKADAKSVIVQALEDPTIPPQERTLDRLGDEGTTIIFAGTETTAR
ALSVGMFHILNNKTILK
KLREELDTLPGVSSGVYSHVQLECLPYL (0)
TGAVQESLRLSHGPAIRLPRVANDKALKYGDYIIPPG (0)
TPVSLCTVLVHQDPCIFPDPHRFDPERWVKASKEGVNLDKFIAAF
TKGTRQCLGINLAYAEIYLTFAKLIRTFNMEIYDTTVDDLTVHHIRLTGAPKQGTGEVKVKVTEKIL*
>CYP58E3 Neosartorya fischeri
53% to CYP58E1
NFIA_042080
Note: this seq does not have an ortholog in A.
fumigatus
MLFQDLSFPAVIGAAFGVFAISVVAGCIYDLFFHPLRNFPGPKRAAIWSFYEFYYDVIRDGTYLWEIEKMHHKYGPIVRI
NSRSLHIHDPEYFSTIYAGSGRKVNKELSAVSGYTFPHSTISTLDHDLHRKRRAIVNPYFSKRAIADIEPVIHERLDALI
SRLAEAKGSTVDLTCAFSAFTADVVTYHFYGSHANYIGSKDFKYGLKDALTVLLNLYNLTRFLPVPATTLKNLPLPILGL
INPNFPE
VVSAREANKKMVLNYLNKPDEEKNAMKDARSKSVIVSALTDPNVPDAEKTLDRLLDEGETIIFAGIDTTARTL
AVALFHLLNNKDVLMKLRKELQAIAKSDGQQWTTTELEAVPYMRGVVQEAIRLAYGLVVRIPRISPHEALQYNGFVIPPG
TPVSQSTYLVNNDASIFPNPQAFDPERWVKAAQDGVSLDKYMVSFSKGSRGCLGINLAYAKLYLGIARVATSLDMELFET
TEKDIAVYHTRGFAFPKEGDGAVKAQVTGLCK*
>CYP58E3 Aspergillus flavus NRRL3357
AAIH02002155.1
Identical to CYP58E3 Neosartorya fischeri (partial seq,
upstream part in a seq gap)
VVSAREANKKMVLNYLNKPDEEKNAMKDARSKSVIVSALTDPNVPDAEKTLDRLLDEGETIIFAGIDTTARTL
AVALFHLLNNKDVLMKLRKELQAIAKSDGQQWTTTELEAVPYM ()
RGVVQEAIRLAYGLVVRIPRISPHEALQYNGFVIPPG
TPVSQSTYLVNNDASIFPNPQAFDPERWVKAAQDGVSLDKYMVSFSKGSRGCLGI
(2?)
NLAYAKLYLGIARVATSLDMELFETTEKDIAVYHTRGFAFPKEGDGAVKAQVTGLCK*
>CYP58E3 Aspergillus terreus NIH2624
AAJN01000124.1
93% to CYP58E3 = ortholog
ATEG_04417.1
36715
MLFQDLSFPAAIGAVFGAVAISVAARCIYDLFFHPLRNFPGPKRAAIWSFYEFYYDVIRD 36894
36895
GTYLWEIEKMHQKY (1)
36993
GPIVRINSRSLHIHDPEYFNTIYAGSGRKVNKELSAVSGYTFPHSTISTLDHDLHRKRRA 37172
37173
IVSPYFSKRAIAEIEPVIHERLNVLISRLAEAKGSIVDLTSAFSAYTADVVTYHFYGTHA 37352
37353
NYIGSKDFKYGLKDALTVLLNLYNLTRFLPVPANTLKNLPLPILGLINPNFPLVVSAREA 37532
37533
NKKMVLGYLNKPDEDKKAMKDARSKSVIVSALTDPNVPDAEKTLDRLLDEGETIIFAGID 37712
37713
TTARTLGVALFHLLNNKDVLMKLRKELQAVAKPDGQQWTTTELEAVPYM 37859 ()
37910
RGVVQEAIRLAYGLVVRIPRISPHEALRYNGFVIPPG (0) 38020
38074
TPVSQSTYLVNNDPSVFPNPQVFDPERWVKAAQDGVSLDKYMVSFSKGSRGCLGI (2?) 38238
38301
NLAYAKLYLGIARVATSLDMELFETTAKAISVYHTRGFAFPKEGDGAVKARVMGLCK* 38474
>CYP58F1 Aspergillus oryzae
GenEMBL BAE64028.1
46% TO 58E2, 40%
to 58C1, 45% to 58D1, 44% to 58B1
46% to 58A3
MALLVILGIGFVTYLVFLSIYRLYFHPLSHIPGPKLAAITHGYEFYHNIIRGGLFIWELERLHEVYGPII
RINPREVHIKDPDYYDDIYASSARKREKDPVLVAQFGLEGSGFSAIDQETHHQRRAPVAKFFSKRAIENQ
EHLIRDSLNKLVGHFQEACRAHTVVSLDAAFAALTSDVIHQYAYGFNPNNLDKEGFNAKVRDGINGLFQL
AHLLYFFPILQTLMNVMPLPLLQVLNPPAFALASQKKELYEQGAAALEKANSKAGSGTLIDTLAAPSMPE
HMRSAHRLMNEGFALVIGGTETTARSLALGAWHLFTREDIRNKLREELKQVMPTPDSQPTWNDLEKLPYM
SGVISESLRLSTGIANRSSRVAPTEALVYKDYTIPPGTPVSETNYFTLMDPEIFSDPHAFDPERWIRAAA
KGQRLDRYLVNFSKGSRMCVGLNLAYAELFLVIATIVRRFDIELYETPKSNIDFARDFGTPYPDKGNFSV
RALVTGVISE
>CYP58F1 Aspergillus flavus
99% to CYP58F1 Aspergillus oryzae
AFL2G_09007
MALLVILGIGLVTYLVFLSIYRLYFHPLSHIPGPKLAAITHGYEFYHNIIRGGLFIWELERLHEVYGPIIRINPREVHIK
DPDYYDDIYASSARKREKDPVLVAQFGLEGSGFSAIDQETHHQRRAPVAKFFSKRAIENQEHLIRDSLNKLVGHFQEACR
AHTVVSLDAAFAALTSDVIHQYAYGFNPNNLDKEGFNAKVRDGINGLFQLAHLLYFFPILQTLMNVMPLPLLQVLNPPAF
ALASQKKELYEQGAAALEKANSKAGSGTLIDTLAAPSMPEHMRSAHRLMNEGFALVIGGTETTARSLALGAWHLFTREDI
RNKLREELKQVMPTPDSQPTWNDLEKLPYMSGVISESLRLSTGIANRSSRVAPTEALVYKDYTIPPGTPVSETNYFTLMD
PEIFPDPHAFDPERWIRAAAKGQRLDRYLVNFSKGSRMCVGLNLAYAELFLVIATIVRRFDIELYETPKSNIDFARDFGT
PYPDKGNFSVRALVTGVISE*
>CYP58F2 Aspergillus niger
fgenesh1_pm.C_scaffold_7000005|Aspni1
60% to CYP58F1
MFVYAWLGIGLLAYYVFRSVYLLYFHPLHKIPGPKLAAITYGYEFYYNVIKGGKFVWEIERLHKIYGTVIRINPDEVHIN
DPDYYEEIYTSRARRREKDPVQIAQFDLDGAVFSSITPETHRQRRSHLDKFFSKQAISNIEYLIHDSLDKIIKTYKEAYQ
SNNVVNLDAGFAGLTADVIYQYAFGFNPGNLDAERFNESVRDASNAFFRGIHILNFFPFIKVIMGLMPLGLLRLKNQTSV
QQDEXXXXXXXXX
KVSNSRGAILDAIAGPHMPAHMRTPVRLMNEGLALAIAGTETTARSLSVGTYHLLTRDDIRLKLREELKTVMPTPD
TRVGRTELEKLPYLSGVINESMRLSTGVSSRMPRVAPTEALVYKEHIIPPGNDPSSHVFILMDPNIFPDPHDFDPERWIR
AAEKGERLDRYLVNFSKGSRICLGMQLAYAELFIVIATLMRMFDMELADTPRETIEFARDFGTPYPEKGNLCVKARITIL
VQQ*
>CYP58F3 Aspergillus terreus
68% to CYP58F1
ATEG_04068.1
MASLILWGLASIIVWFALRSIYRLYFHPLSKFPGPKLAAITSGYEFYYNVVRRGMFIWEIERMHQQYGPIIRVSPREIHI
KDPDYYDEIYASSARKREKDPVVVAQFGLDGSAFSSVSPEDHRQRRAPLDKFFSKQAVTNMEHIIHECLDKLSRHLQDAC
ESHRAVSLDAGFAGLASDVIHQYAWGFNSGNLDAEDFNEHVRDGISGLFRMAHVMFFFPILQTITNAMPLWLLEKVNPFA
FAMASQKHDLYQRAVAALHNSGTKSGRGSIIDAIAGPSMPANMRTPERLMNEGFSLIIGGTETTARSLSLCFYNLITNEP
VRTKLREELRQVMPAPDSQPTWNQLEKLPYLSGVVLETLRLSTGIASRSPRIAPTEALEYKGYVIPPGTLVSETNYFILM
DPNIFPEPHVFDPERWMRAAAKGERLDRYLVNFSKGSRICLGMNLAYAELFLVIATMIRRFDFELYQTSKKDIDFVRDFG
TPYPDEGNFGIKAIVTRVLND*
>CYP58G1 Aspergillus oryzae
GenEMBL BAE64022.1
40% to 58C1, 41%
to 58D1, 39% to 58B1, 35% to 58A3
39% to 52E2, 41%
to 58F1
revised 3/18/2009
MNLPLIWIGLFTAVSYLVIRSIYRLYFHPLSNFPGPKLAAVTHLYEFYYDVVKGGKFIWEMQRMHDQY
GPIVRINPREIHIKDPYYFDPIYTSKGQAKDPYIVRTFATPLSTAATVEHDRHRYRRDLVNPFFSKRSVMGVDYIV
QDKVDKVCKRLTQVHERGTVVSLDDLFAALTADVISHYAYGESLGFLDTENLKNEFRDAVASAGLLCHFA
RFFFVVSMVAETMPALVEWMQPSSKGLWEAKRMIEQMARSSLEKDHEKNANSRKTIFDALCAESVRPEER
TVARVRDEAMVVFGAGTETTARVLATGSYYLYRDKPRLEKLRAEIETVMPDSTDHVSLTQLESLPYLTAV
INESLRMAHSVTMRLPRISPTPLAYKDYIIPPG
TPVSQSVYFMHMDPTLFPNPDSFNPERWLEASSKGERL
TKFLVPFSKGSRICLGMNLAYSELYQMFATLVRCFDLEIQTPPESVRITRDFIIGLPDDADYLKVHSLVT
NAL
>CYP58G1 Aspergillus flavus
99% to CYP58G1 Aspergillus oryzae
AFL2G_09004
MNLPLIWIGLFTAVSYLVIRSIYRLYFHPLSNFPGPKLAAVTHLYEFYYDVVKGGKFIWEMQRMHDQY
GPIVRINPRE
IHIKDPYYFDPIYTSKGQAKDPYIVRTFATPLSTAATVEHDRHRY
RRDLVNPFFSKRSVMGVDYIVQDKVDK
VCKRLTQVHEKGTVVSLDDLFAALTADVISHYAYGESLGFLDTE
NLKNEFRDAV
ASAGLLCHFARFFFVVSMVAETMPALVEWMQPSSKGLWEAKRMIEQMARSSLEKDREKNANSRKTIFDALCAESVRPEER
TVARVRDEAMVVFGAGTETTARVLATGSYYLYRDKPRLEKLRAEIETVMPDSTDHVSLTQLESLPYLTAVINESLRMAHS
VTMRLPRISPTPLAYKDYIIPPG
TPVSQSVYFMHMDPTLFPNPDY
FNPERWLEASSKGERLTKFLVPFSKGSRICLGMNL
AYSELYQMFATLVRRFDLEIQTPPESVRITRDFIIGLPDDADYLKVHSLVTNAL
>CYP58H1 Aspergillus oryzae
GenEMBL BAE56719.1
43% to 58B1, 44%
to 58C1, 42% to 58D1, 38% to 58A3
42% to 58G1, 40%
to 58E2, 42% to 58F1
MDEFTISAGSLCLLSLVVGFIIQSVYRLFFHPLRKFPGPKLGAISHLYEFYYDVIYNGSYLFKIEQLHQKY
(1)
GPVVRINPRELH
INDPYYYEQIYAGSSRIREKDPRFIGVFTTPLPMVATVGHEHHRIRRGLLSSYFSRRALKKAELIIDQKV
DRLLVRFHSAFKCHAVLPLQRVFAALAADIVSEYCYGASQGYLEQKVFQNQMIDAVNYVMSMCHINKSIP
IIPKLLRCVPVGLMEKLGLQMADVIGVRNLIRRQAAKSLDKEWLSHDTNMLSKNVFDAIAAADVAPQEKT
LRRLEEEGAALFGAGIETTARALTVAMFHLISDETMIRKLRDELKQVMLSPASRPTWAELEQLPYLTGVV
NESLRLSFGLVARSPRVSPIESLAYGEYVIPPG (0)
TPVSQSAYFVHMNPQV
FPEPESFNPERWIKAAEKGQYLSRFLVAFSKGSRQCLGMNLAYAELYLTLARIVRLVDMKLVGTTIDNIR
VGRDLGHPAPKAGNFKVKVEVMGIASKS
>CYP58H1 Aspergillus flavus
98% to CYP58H1 Aspergillus oryzae
AFL2G_07403
MDEFTISAGSLCLLLLVVGFSIQSIYRLLFHPLRKFPGPKLAAISHL
YEFYYDVICNGSYLFKIEQLHQKY (1)
GPVVRINPREL
HINDPYYYEQIYAGSSRIREKDPRFIGVFTTPLPMVATVGHEHHRVRRGLLSSYFSRRALKKAELIIDQKVDRLLVRFHS
AFKCHAVLPLQRVFAALAADIVSEYCYGASQGYLEQKVFQNQMIDAVNYVMSMCHINKSIPIIPKLLRCVPVGLMEKLGL
QMADVIGVRNLIRREAAKSLDKEWLSHDTNVLSKNVFDAIAAADVAPQEKTLRRLEEEGAALFGAGIETTARALTVAMFH
LISDETMIRKLRDELKQVMLSPASRPTWAELEQLPYLTGVVNESLRLSFGLVARSPRVSPIESLAYGEYVIPPGTPVSQS
AYFVHMNPQVFPEPESFNPERWIKAAEKGQYLSRFLVAFSKGSRQCLGMNLAYAELYLTLARIVRLVDMKLVGTTIDNIR
VGRDLGHPAPKAGNFEVKVEVMGIASKS*
>CYP58J1 Aspergillus oryzae
GenEMBL BAE62179.1
41% to 58C1 46% to
58C1, 44% to 58D1, 41% to 58B1,
40% to 58A3, 43%
to 58E2, 42% to 58F1, 41% to 58G1,
41% to 58H1
MDSPRLWTGLAGLITYLIVISVYRLFSHPLRNIPGPKLAAVTHLYEWYYDLFLGGKYLFEIERMHERYGP
IV RINPPEIHINDPKYYDEIYASGTHRRNKDAEFVSFTGLLLSSASTTDHDLHRYRRGLMNNFFSKKSVR
GISYFVEEKVHNLMQRFEAFYRCNKVVRLDDAFAAMTSDVITHYCYGKSWDYLDYANLRTDVRKAVRDLT
CSVHFNRIFPIFLAVLKKLPLRWLYAIHPGRSVVLDIQKTIYEQSAEAIHGDKYKIGHNDAVDKHKTIYD
QLTDPSIPAEERSLQRLQDEGLLLISVGTETTARALTTACFHIASDDQLRTRLREELRTVLPTPTSSVTW
SELEKLPYL (0)
TGTVNESLRLGGFLTTRSPRIAPDEPLTYKEYTIPPS (0)
TPVSSSSYFGHKNPNIFPEPEKFSPERWISAGRNNDHLFKYITSFSRGSRICAGMNLAF
LELYMTLAYFVRRFDVELVDTTVEDM KIVRDMRVGFTHRGEPTVYGRIVRVYED
>CYP58J1 Aspergillus flavus
98% to CYP58J1 Aspergillus oryzae
AFL2G_06095
MDSPRLWTGLAGLITYLIVISVYRLFSHPLRNIPGPKLAAVTHLYEWYYDLFLGGKYLFEIERMHERY
(1)
GPIMRINPPEIHINDPKYYDEIYASGTHRRNKDAEFVSFTGLLLSSASTTDHDLHRYRRGLMNNFFSKKSVRGISYFVEEKVH
NLMQRFEAFYRCNKVVRLDDAFAAMTSDVITHYCYGKSWDYLDYANLRTDVRKAVHDLTCSVHFNRIFPIFLAVLKKLPL
RWLYAIHPGRSVVLDIQKTIYEQSAEAIHGDKYKIGHNDAVDKHKTIYDQLTDPSIPAEERSLQRLQDEGLLLISVGTET
TARALTTACFHIASDDQLRTRLREELRTVLPTPTSSVTWSELEKLPYLTGTVNESLRLGGFLTTRSPRIAPDEPLTYKEY
TIPPGTPVSSSSYFGHKNPNIFPEPERFSPERWISAGRSNDHLFKYITSFSRGSRICAGMNLAFLELYMTLAYFVRRFDV
ELVDTTVEDM
RIVRDMGVGFTHRGEPTVYGRIVRVCED*
>CYP58K1 Aspergillus oryzae
GenEMBL BAE63021.1
41% to 58J1, 38%
to 58A1, 40% to 58D2, 39% to 58C1,
38% to 58B1, 42%
to 58J1, 37% to 58H1, 37% to 58G1,
39% to 58F1, 39%
to 58E2
MVMDQAWTWMALVAIAGLFWITRIFYRLYFHPLAKIPGPKLAAASHLLEFYYDVILGGKFLFQVEKMHQK
YGPIVRINPKEVHIIDPTFYNEIYASGMRKRDKYEGFVRSLAADESTVSTVGSEKHRFRRSILQNFFSKR
SVMEFSSAIGERVEKLMRRLEVFEKTQTPVALDVVFSALTSDMITYICYGKDWKFLDHKDFNCDIHQAGV
DFANFFHFNRFFPWVFMTLRALSPRMLALLIPGRAATFKFQESLLKHAIEMAANEQSDAPSKETEKSRPN
VISNLINPSIPYMERSRRRLEDEVITILVAGTEAPVKVLSMAMYYLGSEPAIGEKLRAELKTILPARTST
ATYAELEKLPYLHGVVYESLRISDSVIARFPRIAPTETLRYKDHILPPGTPMSCSSYFISRNHDLFPNPE
KFDPERWIHAAEKGENLKQHLTAFTKGSRICLGINLTIAELFLTIAHMCRRYHILLHNTEPEDVCTTSDL
LAGYTRRGVLKVHAKLKAVRE
>CYP58L1 Aspergillus niger
e_gw1.12.119.1|Aspni1
49% to CYP58D1, 49% to
e_gw1.8.187.1
MYTILLPLLVVICVSVRAIYRIYFHPLSKIPGSKLAAATHLHEFYHDVIRGGKFIWEVEKMHRIYGPIVRINPREVHIAD
PSMYDEIYAGCGRKREKDPCMVSAYASSYAALATVDHDLHRARRAPLNRFFSKKAVIELSGVVQQKVSFLAWHLERVNAE
QAVLVLSTAFTALTGDIITHYLYGKDNGYLRERDLVKRNIVWDILAEGTSACHLFRFFPFIPTLTKALPIQLMRLVRPEL
SNVYAMQEQIARQSDKALASERGAKRRTIYLALSDPSVPARERSVARLRDESFIVLLGGTESTAATLTFATYHLLRNKDM
YFKLRQELQQVMPEPTSEADWAQLERLPYLTAVINEALRLGAAALRPARVAPTETLYYKGYEIPPGTPVSTISYFVHRNP
AIFPDPESFNPERWIQAANRGDNLTRYLVPFTRGSRICIGMNLAYAELYMTLAAIVRRFDLELCETHPKDMEFTREMVVQ
RPEKGVWTLKVRVVGINET*
>CYP58M1 Aspergillus niger
e_gw1.8.187.1|Aspni1
51% to CYP58K1
MALDTSHIWLALVGIASFYVLRSIYRLYFHPLSGIPGPKLAAVTHLYEFYYDVVIHGRFLFQIEKMHQQYGPIVRINPRE
VHISDPSFYDEIYASSTRKRERDPLAYGAFALPYS MIGTMGHEHHRFRRNILNDFFSKRSVLAISPFIEERVEKLRGRFE
GFYRDQSVVNLSDAFAALTSDVITYYCYGKRWGFIEDKDFRSDVHGGNEENTGLAHFNRFFPIVPETMRKIPLHLMALCL
PGKAGMLQFQGSILSTISENTHDKASEKEDRTIFKRLTDPNLPVAERSQRRIEDEVFTLLGAGTETTASTLMIMTYYVSR
DRSIRDKLRSELKQVLPTPTSTATWPELEKLPYLTAVVNESLRLSYGLIMRLPRVAPTETLKYKDYVLPPGTPMSTSTWF
VHRDPSLFPEPDRFDPERWIKAAEEGVNLTRYIVSFMRGSRACIGMNLAYIELYLTIAHVVRRFNFDVEITSPESMRITR
DRIVPGTEKGLMRVYAKVTDMMED*
>CYP58M2 Neosartorya fischeri
55% to CYP58M1
NFIA_057570
Note: this seq has no ortholog in A. fumigatus
MMLSSSWLLPALAYIFLCFLVQSIYRLFFHPLSRYPGPKLTAATFLYEFYYDVIKGGQFLFQIERMHERYGPVVRINPRE
LHIKDPSFYDTVYAGGTHQRDKDPGWVHISGAPLSTFSTVSHDHHRFRRSILSDFFSKKSVTALSPIIEERVLKLMQRFQ
EAYDSRSAIRVDAAFAGLTADVITHYAYGKSWGFLEDPQFRSNIRAAVNETTNAVHWFRFFPFLVTIFRTIPAQIMCFVQ
PSKTALFEFQKSIFDHAAQPKSKRNDSARTIFHRLTDPSIPAEERSLARIQDEAFIILAAGTETTARTLTIATFYMANEP
RIWKKLRDELQSSVLPTLSSTATWAELEKLPYLNAVINEALRLSYGAVIRLPRITPTETLKYKDYVIPPGTPVSMSTYFV
HQDPSIFPDPQTFRPERWIKASDQPEHLTKYIVSFTRGSRICLGMNLAYIELFMTIAYMVRRFDMVLHETTFEDIRIVRD
YVLGLSKHGDLRVFTKVTNMLQE*
>CYP58M3 Aspergillus terreus
55% to CYP58M1
ATEG_02828.1
MSLHSSMASFSLLGLAYLVLRSIYRLYFHPLRHIPGPRLAAISSLYEFYYDVVCQGRYLWEIERLHAIY
(1)
GPIVRINPREVHIIDPSFYDEIYAPSSRRRDKDAKWVPTFGLSQS
MLSTVGHQQHRFRRSLLSSFFSKKSVLQIGPLIDQQREKLFQHLVNFHRTQEVVRLDSAFVALTSDIISAYCYGESGNFL
DDPSFRSDIRASVVDAASICHLARFLPFLQPLIQSVPEGILRALMPGKTALLDFEHSLASKASKALHEGKPSAAAEETIY
DRLTDKSVPPEERSLCRIQDESSLVLAAGTETTARILTIAIYYLSRDQSMLDKLRAELKQALPTPTSLTTWVQLEKLPYL
TAVVRESLRLGFGITCRLPRVAPEEVLRYKGYEIPPGTAMSTCTMFVHRNPEIFPDPDRFDPERWIEGGQLNNKLTKYIV
SFTRGSRICLGINLAYSELYLLIAHLARRFTFEIYDTSEDDVRVTRDLMVGYTRRGDLQVYAKVAEVVQE*
>CYP58M4 Aspergillus terreus
57% to CYP58M1
ATEG_03531.1
METQTLWGILLAFSVYQFFKTIYRLYFHPLSKIPGPRLTAATHLYEFYYDVILGGKFLFQIEKMHQTYGPIVRINPREVH
ISDPTFYDEIYASSTVKRDKDPHLVRIFGAPFSMVGTVGHEHHRFRRSLLNNFFSKRSVLELSPLVTERVQKLMERFEGL
HRSNAVVSLDDAFSALTADVITAYCYGKCWMFLEDESFRNDIRKTVSDMTSYMHINRFFPLVLSAMRAIPLWLLAVLQPG
KSSLLKFQEDIFKETVDSVRDRGKSLSGEKSNPARSTIYDKLSDPSVPPEERTLQRIQDEGVILLSAGTETTGRALCMAA
FHLAYDKSITNRLRDELRQVMPRPTDTVSWTELEKLPYLNGVVYEALRLSYGLIIRLPRISPTDALQYKDHIIPPGTPMS
SSSYIVHRDESIFPNADKFDPERWIRAKNEGKNLSRYLVSFTRGSRTCIGMNLAYMELYLTLASFVRRFDIELHDTTPED
LRFTHDLGIGFTRRGDMQVYAKVTGVVEN*
>CYP58N1 Aspergillus niger
e_gw1.9.613.1|Aspni1
42% to CYP58C1, 39% to
e_gw1.8.187.1
MDYYKALIVLIVYLCLRTIYRLALHPLRGIPGPKLAASTSLYEFYYDAIKGGKYIWEVERMHRQYGKSFTEAILSSLNLT
RGKGPIVRISPREVHIKDPYFYDEIYTSSSIRKRDKDSKLVASFCAPTASFSTVDHNLHRSRRAVISHLFTRKAVVSHEF
LIQDNVGKLASRLESIHKKGSVFSLKIAAAALISDVLAQYMYGTSTHYLDDPTFRSESVASATELASKIHILRHIPVIAT
IFQLLPLALLRPFRLLSDFCDFRLWLRKQSQDALQGKGGSTVRRGPVFDALLRANVPAEEKTLQRLEDESFTLFSAGSET
VSQALSVIFFHLLKNAEFIKTLRKELKQVMPMPTDLATWSELEKLPFLTAVITEALRLSGTSGRLPRVSPTEPLIYGKYI
IPAGTPVGQSNYFAHRDPAMYPNPNAFDPYRWIHAEDENTNPKPFYAPFSKGSRQCIGINLAYATLYLTVATLIRRFDME
ISDSTEDELRTARDFLIPFPEKG
>CYP58P1 Aspergillus clavatus
49% to CYP58H1
ACLA_013370
MASFAMDKDQILVGVLLYISGVIVYRLFLHPLSRFPGPKLAAISSLPEFYHDVLRGGRYIWEIERMHEKYGPIVRINPRQ
LHIKDPCFYDEIYAGGSRRRDKYAEYVNALAADNSSAT TVDHTHHRIRRGFISPYFSKRSVLQFEATISEKLAMLTARLE
EASHAGSVLNLQHVFAALTADIIMQYAYGETHGYLAHESFRNDLVDAVATQLDLLHVNRFFPGLVRLFKDAPPWLLRAVG
LKIADVVEVKLWIRELAAKALARKGRAGGRARETIFDALTAETVPPEEKTLDRLEVESTVIFAAGTDTTARALAVASFHL
MQNQDVLRTLREELKRVMPTPTTSVSWLQLEQLPYLSGV VNESLRLSYALVTRLPRVAPDETLKYGDYMIPPGTPISQSA
YFVHQDPTIFPEPQRFHPERWIRAAEKGENLKRFLVSFNKGSRQCLGINLAYAELYRTIAAVARRFDMELYETTLEDILV
NRDLGFGQPETGRFQVQARVTGIVKE*
>CYP58Q1 Aspergillus terreus
49% to CYP58M1, 48% to CYP58P1
ATEG_02820.1
MAVTLPLIVALAFLWFGSKAIYRLYWHPLSHIPGPKRAAISHLYEFYYDVIRGGTYLF
EVEKMHQKY (1)
GPIVRINPREVHISDPDFYDEIYAPAARVRWKDPKQVPMIGAPFSMGA
MGATWHHGHHRFRRSLIKNHFSRQSIEKITTTIRKKAEILCGRLEEASAIARPLNVSDAFAALTSDIIAGYAFDIDLGFL
EDPLFRNDVYRSALELDMLCHVLKFFPFLLKPVRWLPSSVTEVLGLQNKSLGSLQEVIDQRIISSLRTTGQSGHAQEKER
DSIFTSLCHQEVPPEERTLERLRDESLVLLIAGAEATARALAVFVYYMATGSINVQKLRQELRQVMPTCTSQASWAELEHLPYL
(0)
SGVVNESLRLSFGAIGRLSRIAPTEDLRYKAHPIPRMTPMSSSAYLIHRNADVFPE
PDCFRPERWIGAAASGVNLHRYLVAFSRGTRQCIGINL
AQCQLYFTIAAVARRFDFELFETTEEDIRVARDYITAFPKDGLFDVKVTVRSRLGD*
>CYP58-un1 Aspergillus niger
gw1.19.191.1|Aspni1
43% to CYP58J1 pseudogene fragment C-term, 52% to CYP58M1
TPMGSSSDFIRRDPDNFPSLNNFTSTRWLMENGITIHSTRYLVSFSKGSRGRIEM ()
NLPYFELYLTVAYLVR
>CYP59A1 Aspergillus nidulans
AACD01000132.1 Aspergillus nidulans revised
stcS Aspergillus
nidulans L27825
MYTTIITAVCVLFALHLLDSFYQARQEP
MPSFSLLTGHFGALKQTIDGMPPNATLHSIMLKLSQKFRSGMFY
INMWPFSGTWLVVATPSGAAQIQSLNLSKPNILRRPLETITGGPSLMSMHGETWKRWR
ALFNPGFNPNYLIGLAPLIADEVVVFCEQLRQKARTGTVFQLEPLTLRLTVDTICSVT
LYVVTPVGRWPFLTPDLEIHSSTTKLRTTPLPQRCNGRSNGPRLELPSTPLRRYLTVR
PLVMWYNNRLMNRFIDQEVDRAYREQSGRQSKSVISLALRDYMKEKDGSLEDFKRRVA
PQLRVFLFAGRDTTSSTLLYAFYLLSRHPEALAKVRLEHDQVFGPYHQQVHEKIHQDA
KLLNQLPYTTAVLKETLRLFPPSASMREGGPGVEITDDNGQVYPTAGCNVWTLTVALH
HNSAHWAEAESFIPERWLVGSDHPLYPAKGAWRAFEFGPRSCIGQTLAMLELRVALAM
TLREFDIAPAYDKWDHIYPNDAVKEFNGHRAYQAEKGGGGAHPADGMPCLVTFRV
>CYP59A3 Aspergillus parasiticus aflatoxin pathway
gene cluster
GenEMBL AY371490
MPEFSLLAGHFGTLKKTIQGMPSDATLHSIMLKISQQFSSGIFY
INMWPFSGTWMVVSTPSAASQIQKLNLTKPVILRRPLETVTGGPSMMSMHGETWKKWR
ALFNPGFNPGYIIGLAPNITDEVATFWLSCAKGQQGEVFPLESLTTRLTVDSICSVVL
DTQLHHQIKDHPLATALQRQIDWTTFGTTFNPLKRYLTIRPLVLWYNNKVMDRIIGGE
VDRACRTPPDHPSKSVISLALREYLQEQASTNSTRSLAEFKRLVAPQLRVFLFAGRNT
TSSTLIYSYYLLAQHPEVLAKIRAEHEDVLGADPAEAQGRIKEDVQLLNKLPYTTAVI
KETLRLFPPSASMREGRPDAEIIGEDGQRYPTVGCNVWTLTVALHHNSDYWDQVENFI
PERWLVGPEDPLYPVKGAWRAFEFGPRSCIGQTLAMLELRIALAMTIRQFDITPAYDE
WDSIHPATTAKEVNGHRAYQAERGAGGAHTADGFPCRVKERC
>CYP59A4 Aspergillus oryzae
GenEMBL BAE59520.1
also BAE71324.1
72% to 59A1
MPEFQLLAGHFGTLKKTIQGMPSDATLHSIMLKISQQFPSGIFYINMWPFSGTWMIVSTPSAASQIQKLN
LSKPAILRRPLEMVTGGPSMMSMHGETWKKWRALFNPGFNPAYIIGLAPNISDEVAIFCAQLRKIAQQGE
VFPLESLTTRLTVDSICSVVLDTQLHHQIKDHPLATALQRQIDWTSFGTTFNPFKRYLTIRPLVLWYNNK
FMDRIIDGEVDRAYCTPPGHPSKSVISLALREYLQEQASNNSTRSLAEFKRLVAPQLRVFLFAGRNTTSS
TLIYTYYLLAQHPEALAKIRAEHGDVLGADPAEAQGRIKEDVQLLNKLPYTTAVIKETLRLFPPSASMRE
GRPDAEIIGEDGQRYPTVGCNVWTLTVALHHNSDYWDQVENFIPERWLVGPEDPLYPVKGAWRAFEFGPR
SCIGQTLAMLELRIALAMTIRQFDITPAYDEWDSIHPATTAREVNGHRAYQAERGAGGAHPADGFPCRVK
ERC
>CYP59A5 Aspergillus oryzae
GenEMBL BAE48804.1
92% to 59A4, 71%
to 59A1
MPEFKLLAGHFGTLKKTIQGMPSDATLHSIMLKISKQFQSGIFYINMWPFSGTWMIVSTPSAATQIQKLN
LTKPAILRQPPETVTGGPSMMTMHGETWKKWRALFNPGFNPAYIIGLAPNITDEVATFCAQLRKKAQQGE
VFPLESLTTRLTVNSICSVVLDTQLHHQIKDYPLATALQRQINWTSFGTTFNPLKRYFTIRPLVLWYNNK
VMDRIIGGEVDRAYRTPPDHPSKSVISLALREYLQEQASSNSTRSLAEFKRLVAPQLRVFLFAGRNTTSS
TLIYTYYLLAQHPDILAKIRAEHEDVLGVNPEEVQGRIKEDAQLLNKLPYTTAVIKETLRLFPPSASMRE
GRPDAEIIGENGQRYPTVGCNVWTLTVALHHNSDHWNQVESFTPERWLVGPEDPLYPVKGAWRAFEFGPR
SCIGQTLAMLELRIALAMTIRQFDITPAYDEWDSIHPATTSKEVNGHRAYQAERGAGGAHPADGFPCRVK
ERF
>CYP59A5 Aspergillus flavus
96% to CYP59A5 Aspergillus oryzae
AFL2G_07219
MYLSLLIALGVVSFIRFLTAFYQARQEPMPEFKLLAGHFGTLKKTIQGMPSDATLHSIMLKISKQFQSGIFYINMWPFSG
TWMIVSTPSAATQIQKLNLTKPAILRQPLETVTGGPSMMTMHGETWKKWRALFNPGFNPAYIIGLAPNITDEVATFCAQL
RKKAQQGEVFPLESLTTRLTVDSICSVVLDTQLHHQIKDHPLATALQRQINWTSFGTTFNPLKRYFTIRPLVLWYNNKVM
DRIIGGEVDRAYRTPPDHPSKSVISLALREYLQEQASSNSTRSLAEFKRLVAPQLRVFLFAGRNTTSSTLIYTYYLLAQH
PEVLAKIRAEHEDVLGADPAEAQGRIKEDVQLLNKLPYTTAVIKETLRLFPPSASMREGRPDAEIIGADGQRYPTMGCNV
WTLTVALHHNSDHWNQVESFIPERWLVGPEDPLYPVKGAWRAFEFGPRSCIGQTLAMLELRIALAMTIRQFDITPAYDEW
DSIHPAPTAKEVNGHRAYQAERGAGGAHPADGFPCRVKERF
>CYP59A6 Aspergillus nomius isolate AN13137
AY510454.1
join(49221..49702,49768..50767)
94% to CYP59A5 Aspergillus flavus
gene VerA of aflatoxin biosynthesis
MPEFKLLAGHFGTLKKTIQGMPSDATLHSIMLKISQQFPSGIFY
INMWPFSGTWMIVSAPSAASQIQKLNLTKPAILRRPLETVTGGPSMMSMHGETWKKWR
ALFNPGFNPAYIIGLAPNIADEVATFCTQLRKKAQQAEVFPLESLTTRLTVDTICSVV
LDTQLHHQIKDHPLATALQRQIDWTSFGTTFNPVKRYLTIRPLVLWYNNKVMDRIIDS
EVDRAYRTPPDRPSKSVISLALREYLKEQSSSSSTRSLAEFKRLVAPQLRVFLFAGRN
TTSSTLIYTYYLLAQHPEVLARIRAEHEDVLGGDPADAQGRIKEDVQLLNKLTYTTAV
IKETLRLFPPSASMREGRPDAEIIGEDGQRYPTVGCNVWTLTVALHHNSDHWQQVESF
IPERWLVGPEDPLYPVKGAWRAFEFGPRSCIGQTLAMLELRIALAMTIRQFDITPAYD
EWDSIHPATTAREVNGHRAYQAERGAGGAHPADGFPCRVKERC*
>CYP59A7 Aspergillus ochraceoroseus strain
SRRC 1432
AY092402.3
join(9134..9615,9669..10671)
gene StcS/AflN in aflatoxin/sterigmatocystin
biosynthesis
76% to CYP59A5 Aspergillus flavus
MPEFKLLAGHFAALKQTIQGMPPNATLHSIMLKLSQQFPSGIFY
INLWPFSGTWMIVATMTAASQIQSLNLTKPAILRRPLETITGGPSLISMHGETWKRWR
ALFNPGFNPAYLIGLAPNIADEVAVFRNQLRKKAQQGDIFSLEPLTLRLTVDTICSVA
LDARLFHQQKDHPLAVALQRQIEWASFGTTFNPVKRYLTIRPLVLWYNSRLMNRLIGK
EVDRVHNARPGYSSKSVISLALKQYLKEQSNGDTRQSLEAFKRQVAPQLRVFLFAGRD
TTSSTLLYTFYLLAKHPEILERVRREHDEVFGTDIKKAQSCIAEDPQLLNKLPYTLAV
IKETLRLFPPSASMREGRPDVEIVGDDGRRYPTAGCNVWTLTVALHHNSNHWPEVESF
IPERWLVGHEDPLYPAKGAWRAFEFGPHSCIGQTLALLELRIALAMTLREFNITPAYD
EWDRLHPRDTIKEVNGHRAYQMEKGGGGAHPADGLPCRVTLRTT*
>CYP59B1X # Fusarium graminearum (Gibberella zeae PH-1)
GenEMBL
AACM01000117.1
52362-54017
(+) strand, one intron
renamed
CYP5071A1
>CYP59C1 Aspergillus nidulans AN5766.1 44%
to 59A1 586clan?
Revised 7/18/07
MAVTNLVLTLSIPLLTVIGYGLYCGFQHRRKINELRKRGIPMPKDWSWLT
GHLLSLKKYTDRLPADAHVLLPTHELAVEFADTEMFLMDTWPVFPALVMV
YDPDAALQISTKYNLPKSAIFPSLMHPITGGPSMISMNDAEWKKWRSIFN
PGFSAGNMVDQVSTVVDSVQVFCDILREKAGTGLVHLDDLTTRLTMEVIL
KVTLDMDSNYQRSDNEMVHALNTITKWHSFWDPRVRANPLRPLVQKYYGR
VMDRCIRKELDKRFAEMQQGQRSASTSKRVKSVIALALEAYLADYHQKDG
KASKLDDNFAQYATHQIRLFLFAGNDTTSSSIVYVYHMLSKHPKALARVR
QEHDRIFGTLPSAAPQLLKSNPALLNQCPYTLAVIKETLRLFPPASTTRE
GRDGVTLTDRLGNSYPLGHTIGAEIIHPTIHKNPRLWPQAEEFIPERWLV
DPGHELYPSPAAWRPFEHGPRNCIGQTLVYNEMRIVIVMTARTFNIRPAY
DEWDAMHAAKEGLL (0)
TVHGERAYQTEKAGTHPADGYPCHVALCSGSPIS*
>CYP59C2 Aspergillus niger
e_gw1.2.1390.1|Aspni1
63% to CYP59C1
MAFINLLLTICLPVVVSVVAYGLHALYQHRSKINRLRKQGIAMPPGWNWLTGHMFVLSEYLNRLPPDANVVLATQELAWE
YTDTEIFLLDVWPMSPAQYIVFYPEAASQATTKFNLPKTVIHDRFMRPITGGPSMISVGNAEWKPWRSIFNPGFSAGSMQ
DLLPEVIKSVSVFCDKLREKADSGEMFALDDLTTRLTMDVILKVTLDADVDHQNSDNIIATALGQITKWHSFWDPRVRAN
PLRPLVQGYYGRVADKWIRKALADRFSEMKQVKRDASIRSKRAKSILTLALEAYLENKNEEISEATELDDDFAKHVTYQI
RLFLFAGNDTTSSSIAYVYHLLSKHPEALTQVREEHDRIFGPDPSAAVQLLCEQPSLLNKCPYTMAVIKETLRLYTPAST
MRQGIDGLSLTDRHGNRYPLADDLSVSVLHQAVHLNPRVWPRAREFLPERWLVDADHELYPDPAAYRPFEQGPRNCIGQT
LVYNEMRTVLVMTARTFEIKPAYDEWDATKAKQKGWFDQIAESVGFQNKKPKLLHGERAYQSEKAGTHPVDGYPCRVSLV
A*
>CYP59D1 Aspergillus
oryzae
GenEMBL BAE66084.1
AP007175.1
55% TO 59D2, 41%
to 59A1, 41% to 59C1
470087
MVIAVSDLVGSYGARVALVLALVIVLRFLQEMLKVRLLFYRLRKQ
GLPMPKWNFAAGNLQMLPDLMKRHP
KGSQQSEAFTLLSYEFASSDNCFYIDVWPFTKPLLVVNSP DLAVQACQTYALPKPPVLAKFFNPFAGGPS
IFTTNGPEWKRNRG LFNPAFSTSNILQHTPHI 470671
VEEAEEYVEILREHARKGDTFTLDKMTCDYVLDIIGRVAM (2)
KARLHSQRGRNPVAAALRSQVEWHCQDEQMNPFIRWNPMRPIMQWCNGRTM
NQYIGAELDKRYEAWTQNKPSTRANSIIDIVLAEYMSTRPVRAALDPEFKSWAT
IQLRTFLFAGHDSTAATIVYSIYLLSKHPEILSKVRTEHDEVFGSDISAAAGILKQHPEL
INRLPYTLAVIKETLRLFPAASALREGQPGVYLQDKNGTKYPTEGLCIWIIHGGIQRNPN
YWPDPHAFKPERWLVGPDHPLYPPKGAWRPFEQGLRDCIGQALALLDVKITLVLTLREFD
FQDQYAHWDRLHPRSGPKTVFGERAYQIPQ GGSHPVDGLPCRVSLRNQITK*
>CYP59D1 Aspergillus flavus
99% to CYP59D1 Aspergillus
oryzae
AFL2G_11439
MVIAVSDLVGSYGARVALVLALVIVLRFLQEMLKVRLLFYRLRKQGLPMPKWNFAAGNLQMLPDLMKRHPKGSQQSEAFT
LLSYEFASSDNCFYIDVWPFTKPLLVVNSP
(seq gap)
LFNPAFSASNILQ
HTPHIVEEAEEYVEILREHARKGDTFTLDKMTCDYVLDIIGRVAMKARLHSQRG
RNPVAAALRSQVEWHCQDEQMNPFIRWNPMRPIMQWCNGRTMNQYIGAELDKRYEAWTQNKPSTRANSIIDIVLAEYMST
RPVRAALDPEFKSWATIQLRTFLFAGHDSTAATIVYSIYLLSKHPEILSKVRTEHDEVFGSDISAAAGILKQHPELINRL
PYTLAVIKETLRLFPAASALREGQPGVYLQDKNGTKYPTEGLCIWIIHGGIQRNPNYWPDPHAFKPERWLVGPDHPLYPP
KGAWRPFEQGLRDCIGQALALLDVKITLVLTLREFDFQDQYAHWDRLHPRSGPKTVFGERAYQIPQGGSHPVDGLPCRVSLRNQITK*
>CYP59D2 Aspergillus oryzae
GenEMBL
BAE58153.1, AP007155.1
37% to 59A1, 37%
to 59C1
2825205
MGANTLGWDGLTSRIAVAVATVCLTSFVYKLIKMRLMFYRLRKKGL (0) 2825068
2825008
PTPPWNPILGNLAVMAQLQKKWPSDSREAESFALLSTEAPGCEAGFYVDVWPFSIP
MLVVTSPALAVQACQTYDLPKPDVLQPFINPMAGGSDNLFVSNGAHWKQARELFNHGFSMAAAMSHMTYI
LEEAQVFVQMLKDHARKGDTFSLDALTCRYVMDIIGNVA
LNTRFRFQEQHNPIAAAMRDTIELECGIETS
NFLSRWNPRRLYRQWQNGRTMDYLIGVELDKRYKEWRETAKSSSHPRTQSIMDMVIAEYMKTRPQAQQQQ
ELDPEFKRWATIQIRLFLFVGHDSEATTIIYSLYLLSKNPGVLIKVRAEHDRVFGAGVSSAYDVLTDHPE
KINQLSYTHAVIKETLRLFPPANGLRGGLPGVSLRDEQGRIFPTEGCAIWIVHTAVHRNPSSWPQPHAFI
PDRWLVEPGHPLYPPAGGWRPFEQGPRNCIGQNISLLGIKASLAMLVRQFDFHDAYAEYDRLHPSTGLKT
MFGERAYMIQKGAGHPAQGFPCKVTLR
>CYP59D2 Aspergillus flavus
99% to CYP59D2 Aspergillus oryzae
MGANTLGWDGLTSRIAVAVATVCLTSFVYKLIKMRLMFYRLRKKGL
(0)
PTPPWNPILGNLAVMAQLQKKGPS
DSREAESFALLSTEAPGCEAGFYVDVWPFSIPMLVVTSPALAVQACQTYDLPKPDVLQPFINPMAGGSDNLFVSNGAHWK
QARELFNHGFSMAAAMSHMTYILEEAQVFVQMLKDHARKGDTFSLDALTCRYVMDIIGNVALNTRFRFQEQHNPIAAAMR
DTIELECGIETSNFLSRWNPRRLYRQWQNGRTMDYLIGVELDKRYKEWRETAKSSSHPRTQSIMDMVIAEYMKTRPQAQQ
QQELDPEFKRWATIQIRLFLFVGHDSEATTIIYSLYLLSKNPEVLIKVRAEHDRVFGAGVSSAYDVLTDHPEKINQLSYT
HAVIKETLRLFPPANGLRGGLPGVSLRDEQGRIFPTEGCAIWIVHTAVHRNPSSWPQPHAFIPDRWLVEPGHPLYPPAGG
WRPFEQGPRNCIGQNISLLGIKASLAMLVRQFDFHDAYAEYDRLHPSTGLKTMFGERAYMIQKGAGHPAQGFPCKVTLR*
>CYP59D3 Aspergillus niger
e_gw1.12.714.1|Aspni1
63% to CYP59D2
MPPWDPIFGHLRIMPGLAKKCPSDALQSQTFAVLSMEYPGLQNGFYIDVWPFMCPMFVCTTPPLAVQACQTYSLAKPTEL
LAPFINPMAGGDNFFTTNGAAWKRDRDLFNHAFSMAAVLGHVDYILEEAEIYVEILREHAKKGDTFSMDDLACNYMMDVV
GNVALNTRFNYQTGHNPIAAAMRSTIDLECGREGENNPLRRWNIHRLYRQWRNSQIMDHHIGLELEKRYQEYLQQNQSTK
PRGKSIMDIVIAEYMKHRPASQTHTATLDPEFKAWAIIQIRLFLFVGHDSTAVTIIYCLYLLSKYPDALVKIRAEHEQIF
GPKTTSVATQIKEHPEKTNQMPYTTAVIKEALRLFPPANGLRFGRPGVSLTDTHSSDGRTFPVDDCAVWIVHTAIQRNPG
YWPHAHKFVPDRWLVEPGHELYPPTGGWRPFERGARDCVGQNMALLAIKISLAMVVREFDFDSQYEEWDRMNPASGAVRT
MFGERVYMVAKGAAHPAQGYPCKVRLAA*
>CYP59E1 Mgr034 Mycosphaerella graminicola
39% to 59C1, 9/10 top hits are CYP59, but only 34% to 59D3
N-term is short
MAISNLKLYQEFVIKHSIPKHPLVAEFMENFGGQSNLVSSEGATWKRWRSVFNPGFSNSHIMSQVSSIVDVAQTFCEIMN
DHAKNNTIFRMETATTKLTVDVIGKIVLDLDLNSQKGDNILADTFTSQVRWQSMGAQYQPSELWDIRRPIVQRYNNWVMS
RYLKEKVQERFATREGRGKSKHVVDLALEVYLKEVKGTNSDGGNIKSLDAEFMEAVIANMKTFVFAGHDTTSTVIGCAYY
YLSRNPEALTKLRNELDEVFGPDPSTVAQQLKDDPLLLNKMDYAVAVCKETLRLMPPASTVRAAAPGYRLIDPDTGEHIP
TEHMLVWPSATGIHRHPKYFPDPHTFKPSRFLPGDDTGSNTAAWIPFSKGPRNCIGQELAMIEAKIVLAMTVRTWDFVPA
YDELEKLEGDGTGYPNLKTGILEQYGERMYQIQLGTAKPAEGLPCRLRFTGQ
>CYP59E2 Mycosphaerella fijiensis
61% to CYP59E1 Mycosphaerella
graminicola
e_gw1.7.674.1
MQLQPLTGTHLIWAVGLVLAAYILRFLQRLHFHRTLVNGLPGPPHSYAFGSLISMGKVAAKQPPNAAPQALMQCLKDAYD
LPDAFYFDSWPLGPPIMVITNPDMANQITIKYNPPKHPLVAEFMVNFGGKYDLVSEEGAVWKKWRSAFNPGFAPGHLITQ
VSTIVDECQVFCDIMEKRARNNELFRMEPAATKLTVNIIGKIVLDLDLNAQHGKNVLVDSFMSQIRWQKIGLQYQPSELW
DIRRPIIQRYNNWRMHRWLSARLDERFAGLEARGKSKHVIDLALEAYLKEIKGQKGSVDASKIKGLDPDFKEAAISNMKT
FTFAGHDTTSSAICYSFYYLSKYPETLAKIRKEHEEIFGPDPDVVAQKLKSDPHLLSKMEYTLAVTKEVLRMQPPASTIR
LGQANLTLHNPDTGENMPTNHFMLWPVNVGMHRNPRNWPNPDIFDPERFIPGSAVYAENNKDAWVPFSKGVRNCIGQELA
IMEAKVILAMIVRKFDFISAYNELEKLVGDGSSYPNYLSGVREQFGERAYQVQLGTAKPAEGMPCRMKLAKR*
>CYP60A1
Aspergillus parasiticus L40839
MHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSDKGLRHERSLI
ERSIDLLITQLHENCGQGSGLALWFNWATFDIIGDLAFGDSFGCLENVQTHPWIASIQ
GNVKLIPILNAFRRYRLDGLLRLLGSRKLLEQRRRNAQFTTDQVDRRLKNSSTPRGDI
WDAVLAQKPDGEPPMTRDEMISNASAIVLAGSETSATLLSICTWLLLKNPSHLHQLTS
RIRSQFTHASEIDSQSVSRVEGLQAVLEESLRLYPPVPMQSNRIVPQAGAYIAGGWVP
GGTSVGLQQFVACRSSSNFHRPDEFLPERWQGQGEFAHDRREVSQPFSIGPRNCIGRQ
LAYVEMRLILVKLLWHFDLRLDTTRMKDTDWLAEQGIWILWDKNRCGLRWNLAMSSSS
NYSL
>CYP60A2 stcF
Aspergillus nidulans U34740 AN7818.1 53 clan
revised 7/19/07
MILPLILVLYLLSTAAYRLWLHPVRNYPGPCWWAVWRVPYLKGT
IRGTIVRDIQRLHNQYGPVVRIAPDELSYITPEAAKPIYTSSPEFPKDPMLLPPFHNG
APGILAADYAHHRRYRRLLASAFSEKGLRAQQGMIQSHIDRLMTRLQGNCSSGSLDMT
VWFNWATFDIIGDLAFGEPFGCLERMETNPWIASIQGNVKSIPILNALRRYRLDRLIE
FLAPPRLLEMRRRNAQFTAEKVDRRLKHATTTRGDLWDSVLADPPDGEPPMSRAEMVS
NASAIVLAGSETSATTLSGCLWLLLTNPEYLQQLTERIRARFSTATVIDAQTVTQIQG
LQAVLDESLRLYPAVPMQSNRIVPPPGARLAGSWVPGGTSVAVQQFAACRSPTNFHRP
DEFIPERWEKEGEFINDRREASQPFSIGPRNCIGRQLALAEMRLILVHLLWHFDIELD
RRRMENMDWMAVQGI
WILWDKKPLWVVLKNRST*
>CYP60A3
Aspergillus parasiticus avnA U62774
MGGDGWPSDGHILLLIVLTVLTPPSLALYRLWIHPLRSYPGPRW
WAIWRGPYILSNIRGNLVRDLQRLHQQFGPVVRIAPNELSFIVPEAASPIYTSNPEFP
KDPMHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSDKGLRHERSLIERSIDLLITQL
HENCGQGPLDLALWFNWATFDIIGDLAFGDSFGCLENVQTHPWIASIQGNVKLIPILN
AFRRYRLDGLLRLLGSRKLLEQRRRNAQFTTDQVDRRLKNSSTPRGDIWDAVLAQKPD
GEPPMTRDEMISNASAIVLAGSETSATLLSGCTWLLLKNPSHLHQLTSRIRSQFTHAS
EIDSQSVSRVEGLQAVLEESLRLYPPVPMQSNRIVPQAGAYIAGGWVPGGTSVGLQQF
VACRSSSNFHRPDEFLPERWQGQGEFAHDRREVSQPFSIGPRNCIGRQLAYVEMRLIL
VKLLWHFDLRLDTTRMKDTDWLAEQGIWILWDKKPLWVTLEPRNE
>CYP60A5 Aspergillus oryzae
GenEMBL
BAE71325.1, BAC45242.1, BAE59521.1
95% to CYP60A3
MGGDGWPSDGHILLLIVLTVLTPPSLALYRLWIHPLRSYPGPRWWAIWRGPYILSNIRGNLVRDLQRLHQ
QFGHVVRIAPNELSFIVPEAASPIYTSNPEFPKDPMHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSDK
GLRQQRSLIERSVNLLITRLHENCGQGPLDLTLWFNWATFDIIGDLAFGNSFGCLDNVQTHPWISSIQGN
VKLIPILNAFRRYRLDGLLQLLGSRKLLEQRRRNAQFTTDQVDRRLKNSSTPRGDIWDAVLAQKPDGEPP
MSREEMISNTSAIVLAGSETSATLLSGCTWLLLKNPGHLHQLTSRIRSQFTHASEIDSQSVSRVEGLQAI
LEESLRLYPPVPMQSNRIVPQSGAYIAGGWVPGGTSVGLQQFVACRSSSNFHRPEEFLPERWQGQGEFAH
DRREVSQPFSIGPRNCIGRQLAYVETRLILVKLLWHFDLRLDTTRMKDTDWLAEQGIWILWDKNPLWVNL
EPRNE
>CYP60A5 Aspergillus flavus
98% to CYP60A5 Aspergillus oryzae
AFL2G_07217 revised
Bottom HALF (two adjacent P450s in this
gene model CYP60B3 and CYP60A5)
MGGDGWPSDGHILLLIVLT
VLTPPSLALYRLWIHPLRSYPGPRWWAIWRGPYILSNIRG
NLVRDLQRLHQQFGSVVRIAPNELSFIVPEAASPIYTSNPEFPKDPMHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSD
KGLRQQRSLIERSVNLLITRLHENCGQGPLDLTLWFNWATFDIIGDLAFGDSFGCLDNVQTHPWISSIQGNVKLIPILNA
FRRYRLDGLLQLLGSRKLLEQRRRNAQFTTDQVDRRLKNSSTPRGDIWDAVLAQKPDGEPPMSREEMISNASAIVLAGSE
TSATLLSGCTWLLLKNPGHLHQLTSRIRSQFTHASEIDSQSVSRVEGLQAILEESLRLYPPVPMQSNRIVPQSGAYIAGG
WVPGGTSVGLQQFVACRSSSNFHRPEEFLPERWQGQGEFAHDRREVSQPFSIGPRNCIGRQLAYVEMRLILVKLLWHFNL
RLDTTQMKDTDWLAEQGIWILWDKKPLWVTLEPRNE
>CYP60A6 Aspergillus nomius isolate AN13137
AY510454.1
complement(join(51845..52180,52258..53352,53400..53456))
92% to CYP60A3
gene AvnA of aflatoxin biosynthesis
MGVDGWLSDGHFRLLILLIVLTPPSLAVYRLWIHPLRSYPGPRW
WAIWRGPYILSNTRGSLVRDLQRLHQQFGPVVRIAPNELSFIAPEAAAPIYTSNPEFS
KDPMHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSDKGLRQQRGLIERSVNLLITQF
HENCGQGPLDLTLWFNWATFDIIGDLAFGDSFGCLDNVQTHPWIASIQGNVKLIPILN
GLRRYRLDGLLRLLGSRKLLEQRRRNAQFTTDQVDRRLQNSSTPRGDIWDAVLAQKLD
GEPPMSRAEMISNASAIVLAGSETSATLLSGCTWLLLKNPEHLHQLTSRIRSEFSHAS
EIDSQSVSRVEGLQAVLEESLRLYPPVPMQSNRIVPSTGAHIAGGWVPGGTSVGLQQF
VACRSPSNFHRPDEFLPERWQGQGEFAHDRREVSQPFSIGPRNCIGRQLAYVEMRLIL
VKLLWHFDLRLDTTRMKGTDWLAEQGIWILWDKKPLWVTLEPRDK
>CYP60A7 Aspergillus ochraceoroseus strain
SRRC 1432
AY092402.3
complement(join(29656..30030,30172..31266,31338..31385))
gene AflG in aflatoxin/sterigmatocystin
biosynthesis
79% to CYP60A3 Aspergillus parasiticus avnA
gene model revised at one intron boundary
MDVLRSFPLQLLGLRDFLILGSLGAYRLWLHPLRSYPGPRWWAL
WRVPYLQSTIRGTIVRDLQRLHEQYGPVVRIAPDELSFINPEAAKPIYTSNPEFSKDP
MHLPPFHNGVPGILAADHAHHRRYRRLLAFSFSDKGLKAQQGMIQQYIDQLIVRLHEN
CSTGPVDMTLWYNWATFDIIGDLAFGESFGCLEKVETHPWIASIQGNVKAIPILNALR
RYRLSGVLGLLAPRNLLEMRRRNAQFTADKVDRRLQHPGTARGDLWDSVLADNPNGES
PMSRDEMVSNASAIVLAGSETSATLLSGCTWLLLKNPEYLNTLTERVRSQFARAADID
AQTVTQVEGLQAVLEESLRLYPPVPMQSNRIVPPQGAQIAGMWVPGG
(0)
TSVAVQQFVACRSADNFHRPNEFLPQRWQGQGEFANDRREASQPFSIGPRNCIGRQLAYAEMRL
ILVHVLWHFNLRLDQGRMKDADWLAEQGIWILWDKNHCGLCWNRGREKVEEDDAT*
>CYP60B1 stcL
Aspergillus nidulans U34740, AN7813.1, revised 7/18/07
MAFLSLPILTALGA
VVYVLFQLVYNLYFHPLRDYPGPLLW
RASSLPWKLTLLRGTMHHDLMRHHQTYGDTVRIKPDEISYANGQAWRDIHAHVPGRPE
FLKDPVRLPLAPNGVMSILVSDTRNHARFRSLFGHAFSDKGLRAQEPTIARYADLLVE
VLREVADTGKSVEMVRYFNMAIFDSIGALSFGESFDSLRNRELHPWVDTIHKNLKSVA
ISHVLRSMGVEFLAPYLMPAELRGKRQENYTYAIEKLKKRMQKTGDQGDFWDRVIVKS
ADGNQSGDGMSYGEMINNAAVMVVAGSETTSSALCGCTYLLCKFDKMDKAVAEVRGAF
AAADQIDLVSVSRLPYLTAVIDETLRMYPSVPGQPPRVVPEGGAIVCGRFVPAETRVG
VSHLGAYYAPYNFSHADKFIPERHLAGAKLEEPFRHDNYAAYQPWSVGVRNCIGRNLA
YAEVRLTLAKLLWHFDISLDEERTGNFLDQKIWSIWAKRELYLEIRTREF
>CYP60B2 Aspergillus ochraceoroseus strain SRRC 1432
GenEMBL AY092402.3
complement(join(46781..47113,47181..48332))
Cary,J.W., Beltz,S.B., Bennett,C.A. and Klich,M.A.
Molecular Characterization of the Aflatoxin Biosynthetic Cluster
from Aspergillus ochraceoroseus.
Unpublished
function="desaturation of aflatoxin precursor VER B to VER A
84% to CYP60B1 Aspergillus nidulans StcL
probable ortholog of CYP60B1
gene AflL/StcL
MALPTLPVLAVLIGASYILVQLVYNLYFHPLRDYPGPLLWRASS
LPWKFTLLRGTMHHDLMRFHQKYGDTVRIKPDEISFANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPIGVMSILVSVTRFLARFRSVFGLAFSVKGLRAQEPTIVQYADLLVEVLRE
VADTGKSVEMVHYFNMAIFDSIGALSFGESFDSLKNRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYTYAIEKLKRRMQMTGDQGDFWDRVIVKSADGN
QSGDGMSPGEMLNNAAVMVVAGSETTSSALCGTTYLLCQSGKMEKAVAEIRNAFPTPD
KIDLVTVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGKFLPAETRVGVSHL
GAYYADYNFTRPEKFIPERHLQKMEEPFKHDNYGAYQPWSVGVRNCIGRNLAYAEVRL
TLAKLLWHFDITLDEAKTGNFLDQKIWSIWANGELYMSFKARKV
>CYP60B3 Aspergillus oryzae
GenEMBL
BAE71326.1, BAC45243.1, BAE59522.1
81%
TO 60B1
probable ortholog
of CYP60B1
MYFLSLPALAIIVPVGYVLLHLGYNLFFHPLRGYPGPLLWRASSLPWKIALLRGTMHHDLMRFHQKYGDT
VRVKPDEISYANAQAWRDIHAHVPGRPEFLKDPVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGL
RTQESTIVQYADLLVEVLREMANTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNL
KSVAISHVLRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDLGDFWDKVLVKSADDNQRGD
GMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKATAEIRKSFASPEDIDLISVSHLPYLAAV
IDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHLGAYFADYNFTHADKFIPERHLQKTEEPY
KYDNYGAYQPWSVGLRNCIGRNLAYAEVRLTLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFIK
TRGTSSSSPQ
>CYP60B3v1 Aspergillus flavus
97% to CYP60B3 Aspergillus oryzae
AFL2G_07217 revised
TOP HALF (two P450s in this gene model
CYP60B3 and CYP60A5
MYFLSLPALAIIVPVGYVLLHLGYNLFFHPLRGYPGPLLWRASSL
PWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKDPVRLPLAPNGVMSILVSDTKNHA
RFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLREVADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDA
IHKNLKSVAISHVLRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDNQRGDGMSAG
EMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKSTAEIRKNFASPEDIDLISVSHLPYLTAVIDETLRMYPAVPGQP
PRVVPAGGATVCGRFVPEETRVGVSHLGTYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGLRNCIGRNLAY
AEVRLTLAKLLWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSTPQ*
>CYP60B3v2 Aspergillus flavus strain SRRC 141
GenEMBL AF106960
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene 85% identical
to 60B2
97% to 60B3v1 ortholog
99% to CYP60B3v3
Aspergillus flavus strain SRRC 1007
formerly CYP60B4v1
MYFLSLPALAIVIPVGYVLFQLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VANTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIKKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPYKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFMKTRGTSSSSPQ
>CYP60B3v3 Aspergillus flavus strain SRRC 1007
GenEMBL AF106959
formerly CYP60B4v2
MYFLSLPALAIVIPVGYVLFQLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VANTGCSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKVEKATGEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPYKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSSPQ
>CYP60B3 Aspergillus parasiticus strain RH1
GenEMBL AF106958
formerly CYP60B4v3
MYFLSLPSLVIVIPVGYLLFHLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRFHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPASGATVCGRFVPEETRVGVSHL
ATYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSSPQ
>CYP60B3 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
formerly CYP60B4v3
MYFLSLPSLVIVIPVGYLLFHLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRFHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPASGATVCGRFVPEETRVGVSHL
ATYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSSPQ
>CYP60B3
Aspergillus nomius
AY510454
complement(join(53898..54266,54322..55473))
gene VerB of aflatoxin biosynthesis
94% to CYP60B3 Aspergillus flavus
MYFLSLSVLALVTLVSYVLFHLGYNLFLHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAEAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTRNHARFRSLFGHAFSDKGLRTQESTILQYADLLVEVLRE
VADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMRMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGSMYLLCLSGKIEKATAEIRKSFASPE
EIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGKFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGIRNCIGRNLAYAEVRL
TLAKILWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMTLKSRDTSCSWPSTSSSPQ*
>CYP61A1 Yarrowia lipolytica
64% to CYP61A1 Saccharomyces paradoxus
CAG84120.1
MNATQPESHIVQWLTWTQDTIGFGTLAATVLLIALLYDQFSYVKSKGSIAGPPLKMWPIIGPFLDSINPDFEKYKAQWAS
GALSCVSVFHKFVVLASDRDLTRKIFNSSAYVKPCVVDVAIKILRPTNWVFLDGKAHVDYRRGLNGLFTNRALSMYLPIQ
EGIYDTYFDKFVEMSKDGHVPYMPIFREINCALSLRTFCGNYITEEQIKEIAHDYYLVTAALELVNFPIILPFTKAWYGK
KAADKVMDIFAKCAQMAKDHIKAGGDVTCTMDAWIAIMNGRDFDSDHGTVPNKKIRKFTNKEISETIFTFLFASQDASSS
ATTWLFQIVADRPDVYAKIREEQLAVRGGDPNVPLSLELTEKMTYTNMVVKECLRLRPPVIMVPYVAKKDFPISDTYTVP
KGSMIIPTVYPSLHDPEVYERPDEFVPERWLPDGDGTKNAKNWLVFGTGPHYCLGQKYALMNFTNMIGKACMNLDFTHKV
TPLSEKVRVFATIFPDDDCLLQFKKRE
>CYP61A1 S.
cerevisiae bakers yeast Z49211 Z71257
MSSVAENIIQHATHNSTLHQLAKDQPSVGVTTAFSILDTLKSMS
YLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWPIIGPFLESLDPKFEEYKAKWAS
GPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHT
DYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCAL
SLNSFCGNYITEDQVRKIADDYYLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFE
NCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHREFTNKEISEAVFTFL
FASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMV
IKETLRYRPPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIP
ERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFALYTDFHHTVTPLSE
KIKVFATIFPKDDLLLTFKKRDPITGEVFE
>CYP61A1 Saccharomyces paradoxus
98% to CYP61A1
S. cerevisiae Spar_17277
MSSVAENIIQQATHNSTLHQLAKDHSPVGATTAFRILNTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWP
IIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHT
DYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDY
YLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDDSRIYHRE
FTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYR
PPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQT
YVMITFAALLGKFALYTDFHHKVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE
>CYP61A1 Saccharomyces mikatae
97% to CYP61A1
S. cerevisiae Smik_16456
MSSVAENIIQQASHNSTLQQLAKDQSSVGITTAFSILDTLKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWP
IIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHT
DYRKSLNGLFTKQALAQYLPSLELIMDKYMEKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDY
YLVTAALELVNFPIIIPYTKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDESRIYHRE
FTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYR
PPVLMVPYVVKKNFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDEFIPERWVEGSKASEAKKNWLVFGCGSHVCLGQT
YVMITFAALLGKFALNTDFHHKVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE
>CYP61A1 Saccharomyces kudriavzevii
97% to CYP61A1
S. cerevisiae Skud_Contig2054.8
MSSIAENIIQQATHNSTLHQLAKDESSLGVTTAFSILETIKSMSYLKIFATLICILLVWDQVAYQIKKGSIAGPKFKFWP
IIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHT
DYRKSLNGLFTKQALAQYLPSLEQIMDKYMDKFVRLSKENNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDY
YLVTAALELVNFPIIIPYSKTWYGKKTADMAMKIFENCAQMAKDHIAAGGKPVCVMDAWCKLMHDAKNSNDDESRIYHRE
FTNKEISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLAVRNNDMSTELNLDLIEKMKYTNMVIKETLRYR
PPVLMVPYVVKKNFPVSPSYTAPKGAMLIPTLYPALHDPEVYENPDDFIPERWVEGSKATEAKKNWLVFGCGPHVCLGQT
YVMITFAALLGKFALYTDFHHKVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE
>CYP61A1 Saccharomyces castellii
83% to CYP61A1
S. cerevisiae Scas_Contig709.53
METIMDNSTMEFVQQQTPSTLISTIQQLSYWKIFVTFICIVLVWDQISYQIKKGSIAGPRFKIWPIIGPFLESLDPKFEE
YKAKWDSGALSCVSIFHKFVIISSTRDISRKIFQSSKFVKPCVVDVAIKILRPTNWVFLDGKAHIDYRKSLNGLFTKTAL
AQYLPSQEQVMDKYLQKFIEISKENNYEPQVFFHEMREILCALSLRAFCGEYITEDQIRKIADDYYLVTAALELVNFPII
IPFTKTWYGKRTADAAMKIFEQCAQMSKDYIAKGGKPICVMDAWCKLMHDAKTKNDEDSRILHREFSNKEISEAIFTFLF
ASQDASSSLACWLFQIVADRPDILEKIRKEQMEVRNNDMSTELNIELIDKMKYTNMVIKETLRYRPPVLMVPYVVKEKFP
VTPNYTAPKGSMLIPTLYPSLHDPEVYENPDEFIPERWEEGSPASEAKKNWLVFGCGPHVCLGQTYVMITFAALLGKFAL
YTDFEHKITPLSEKIKVFATIFPKDDLLMTFKKRDPITGKVFE
>CYP61A1 Saccharomyces bayanus
93% to CYP61A1
S. cerevisiae Sbay_17696
MSSVAENIIQQAANNSTLHQLAKGGSSLGFTKAFNVLDALKSMSYLKMFATLICILLVWDQLAYQIKKGSIAGPKFKFWP
IIGPFLESLDPKFEEYKAKWASGPLSCVSIFHKFVVIASTRDLARKILQSSKFVKPCVVDVAVKILRPCNWVFLDGKAHT
DYRKSLNGLFTKHALAQYLPSLELIMDKYMEKFVRLSKDNNYEPQVFFHEMREILCALSLNSFCGNYITEDQVRKIADDY
YLVTAALELVNFPIIIPYSKTWYGKKTADMAMKIFENCAQMAKDHIAAGGEPVCVMDAWCKLMHDAKNSNDDDARIFHRE
FTNKEMSEAVFTFLFASQDASSSLACWLFQIVADRPDVLEKIREEQLAVRNNDMSTELTLDVIEKMKYTNMVIKETLRYR
PPVLMVPYVVKKNFPVSSNYTAPKGAMLIPTLYPALHDPEVYENPDDFIPERWEEGSKASMAKKNWLVFGCGSHVCLGQT
YVMITFAALLGKFALSTDFHHKVTPLSEKIKVFATIFPKDDLLLTFKKRDPITGEVFE
>CYP61A1 Saccharomyces kluyveri
79% to CYP61A1
S. cerevisiae Sklu_Contig2168.4
MSTVVKYAQNAASNSILNSGNNATTTATNAVATTVQNVIDSVQSISYWKLFVTIICVGLVWDQVSYQIKKGSIAGPKWKV
WPVIGPFLESLDPKFEEYKAKWDSGPLSCVSIFHKFVVIASTRDLARKILQSPKFVKPCVVDVAIKILRPSNWVFLDGKQ
HVDYRKSLNGLFTKSALAQYLPSQENVMNKYLEKFVELSKENKYEPQVFFHEMREIMCALSLKAFCGDYITEDQIRKVAD
DYYLVTAALELVNFPIILPFTKTWYGKKTADMTMKIFEQCAQMAKDHIASGGPTTCVMDAWCKLMHDAKNQNDADSRLLH
REFSNKEISEAIFTFLFASQDASSSLACWLFQIVADRPDVLEKIREEQLKVRENDPTKALSLDLIEEMKYTNMVVKESLR
YRPPVLMVPYVVKQKFPIAPNYSAPKGSMLIPTLYPALHDPEVYENPDEFIPERWVEGSPANQAKRNWLVFGSGPHVCLG
QTYVMMTFTALIGKFAMYTDFEHKVTPLSEKIKVFATIFPKDDLLLSFKKRDPLTGENII
>CYP61A1 Kluyveromyces waltii
82% to CYP61A1
S. cerevisiae kwal_095-g1.1 C-term part only
MCALSLKAFCGDYITESQIRKVADDYYLVTAALELVNFPIILPFTKTWYGQRTADMTMKIFEKCAQMAKDHIAAGGKPKC
VMDAWCELMHNAKNKNDEDSRLFHREFTNREISEAVFTFLFASQDASSSLACWLFQIVADRPDVMQKIREEQLRVRNNDP
SKPLSLDLIDEMKYTYMVVKETLRYRPPVIMVPYVVKNKFPIAPNYTAPKGAMLIPTLYPALHDPEVYDDPEEFIPERWV
EGSPANEAKKNWLVFGSGSHVCLGQTYVMMTFTALIGKFAMYTNWEHKVTPL
>CYP61A1 Ashbya gossypii ATCC 10895
75% to CYP61A1
S. cerevisiae NP_982999.1
MDAIGFGEQAGWLWRALAALWAWRVLAALVLVLVADQAAYRRNKGRIAGPAWKMWPLIGPFLESLDPKFEVYQAKWASGP
LSCVSIFHKFVVIASTRDLTRKILQSPKYVKPCLVDVAKKILRPTNWVFLDGQAHLDYRRSLNGLFTRDALARYLPSQEA
VIDRYMAKFVAFSRETDYEHRVFFHEMREMLCALSLKAFCGSYITDDQVRKIADDYYLVTAALELVNFPLILPFTKTWYG
KRTADMAMKIFERCAQEAKQHIAAGGEPTCVVDAWCKLMLDAKAKDDADSRLLHRKFTNREMSEALFTFLFASQDASSSL
ACWLFQIVADRPDVLAKIREEQLAVRRNDPSVPLSLELIDQMKYTHMAVKECLRYRPPVLMVPYQVHEAFAVSADYTAPK
GSMLVATMYPALHDPAVYENPDDYIPERWDGEQSPANQAKKNWLVFGSGPHVCLGQKYVFMTFTALIGKFALFTEFDHKV
TSLSEKIKVFATIFPQDDLLMSFKKRDPLTGQTTE
>CYP61A1 Pichia stipitis
82% to CYP61A1 Debaryomyces hansenii
JGI model estExt_genewise1_human.C_chr_6.10410
MSFNTTSPLAVGYKNAQQYLDIETFITKAQETYSSLTWIQLIFSVIAIILSYDQIMYQIRKGSIAGPRFKIWPIIGPFLE
SLDPKFEEYKAKWDSGELSCVSIFHKFVVIASSRDLARKILASPKYVKPCVVDVAIKILRPTNWVFLDGKQHTDYRRSLN
GLFSQKALEIYIPVQEKYMDIYLDKFTKFDGPREFFPEFRELLCALSLRTFCGDYITEEQIALIADNYYRITAALELVNF
PIIIPYTKTWYGKKIADDTMKIFEKCAAMAKVHINEEAGKPACVMDEWIYLMKDAREKHSEDPEAKLLIREFSNKEISEA
IFTFLFASQDASSSLACWLFQIVADRPDVVEKIREEQLAVRNNDPSVPLSLDLINEMSYTNNVVKESLRYRPPVLMVPYV
VKQSFPVTETYTAPKGSMIIPTLYPALHDPEVYEDPDTFIPERWENATGDMYKRNWLVFGTGPHVCLGKNYVLMLFTGML
GKFVMNADLIHHKTALSEEIKVFATIFPKDDLIMEWKSRNPLEA
>CYP61A1 Debaryomyces hansenii
80% to CYP61A1 Candida lusitaniae
CAG86871.1
MSTNSTSEIVDNLSGSFGDTSFFIKTANDLYMNMSWLQLIITTIVLGLSYDQIMYQIRKGSIVGPRLKVWPIIGPFLESL
DPKFEEYKAKWDSGPLSCVSIFHKFVVIASSRDLARKILGSPKYVKPCVVDVAIKILRPTNWVFLDGKAHSDYRKSLNGL
FSQKALELYIPVQEKYMDLYLEKFVTLDGPTEFFPQFRELLCALSLRTFCGDYITEEQISLITDNYFRITAALELVNFPI
IIPYTKTWYGKKIADETMKIFESCAGMSKKHINEDNGKPGCVMDEWIYLMKDAREKHSDDPESKLLIREFSNREISEVIF
TFLFASQDASSSLACWLFQVVADRPDIVAKIREEQLRVRDQDPSKPLNLELINEMTYTNNVVKESLRYRPPVLMVPYVVK
QSFPVTDTYTAPKGSMIIPTLYPALHDPEVYEDPDSFIPERWENATGDMNKRNWLVFGTGPHICLGKTYVLMLFTSMLGK
FVMNSDIIHYPTPLSEEIKVFATIFPKDDLILEWKRRNPLQV
>CYP61A1 Lodderomyces elongisporus
84% to CYP61A2
C.albicans
LELG_05188
MSEFNVSTPLVDRLLNEQAKSFISSNQQINYLYNLYQTSSWLQIIATFIVSVLLYDQVRYQLNKGSIAGPKFKVWPIIGP
FLESLDPKFEEYKSKWDSGELSCVSIFHKFVVIASSRDLARKILSSPKYVKPCVVDVAIKILRPTNWVFLDGKAHTDYRR
SLNGLFSQKALEIYIGVQEKYMDIYLERFCKYEGPREFFPEFRELLCALSLRTFCGDYITEDQIALVADNYYKVTAALEL
VNFPIILPYTKTWYGKKIADETMKIFANCSAMAKVHIENGGSPTCIMDEWIFLMKEAREKHLDDPESRLLIREFSDKEIS
EVIFTFLFASQDASSSLACWLFQIVADRPDIVAKIREEQLRVRNNDPSVPLDLNLINEMTYTNNVVKESLRYRPPVLMVP
YVVKQPFPVTESYTAPKGSMIIPTLYPALHDPEVYDDPDTFIPERWETASGDMYKRNWLVFGTGPHVCLGKNYVLMLFTG
MLGKFVMNSDIVHHKTALSEEIKVFATIFPKDDLILEWHKRDPLAV
>CYP61A1
Candida guilliermondii
79% to CYP61A1 Candida dublinensis
PGUG_05085.1
MDVNSTNQVTDMYSTPIGGTVGSYVNDVFTNLTWVQIFCTTVVLIFTYDQVMYQLRKGSIAGPRVKMWPIIGPFLESLDP
KFEEYMAKWNSGPLSCVSIFHKFVVIASDRDLTRKILASPKYVKPCVVDVAVKILRPSNWVFLDGKAHSDYRRSLNGLFR
SKALEIYIPVQEKYMDKYLEKFTNFDGPRKFFPEFRELLCALSLRTFCGDYITEEQIKLIADNYYRITAALELVNFPIII
PYTKTWYGKMIADDTMKIFESCAAMAKKHINEENGTPTCIMDEWISLMKDAREKHSEDAASKLLIREFSNREISEAIFTF
LFASQDASSSLACWLFQIVADRPDVVKKIREEQLKVRDNDPSKPLSYDLINEMTYTNFVVRESLRYRPPVLMVPYVVKQK
FPVTETYSAPKGSMLIPTLYPALHDPEVYDDPDSFIPERWYDASKEMTNRNWLVFGTGPHVCLGQNYVLMLFTGMLGKYM
MNADLIHHKTPLSEEIKVFATIFPKDDLIMEWHSRDPSKL
>CYP61A1
Candida parapsilosis
79% to CYP61A2 C.albicans, N-term does not match
CPAG_03443
MDSFNQTVELAGSSHTNQIFNFLTSNKQINYFYQLYLSASWIQIVIASVV
LILSYDQVKYQLNKGSIAGPKFKIWPIIGP
FLESLDPKFEEYKAKWDSGALSCVSIFHKFVVIASTRDLARKILSSPKYVKPCVVDVAIKILRPTNWVFLDGKEHTDYRR
SLNGLFSQKALEVYIPVQEKYMDIYLERYLNYNGPRKFFPEFRELLCALSLRTFCGDYITEDQISLIADNYFRITAALEL
VNFPIIIPYTKTWYGKKIADDTMKIFENCAAKAKVHIGQGGKPTCVMDEWIYLMKEAKDKHLDDPESKLLIREFSNREIS
ETIFTFLFASQDASSSLACWLFQIVADRPDVVEKIREEQLRVRNGDMNVRLDLELIQKMKYTNNTVRETLRYRPPVLMVP
YVVKQNFPITESYTAPKGSMVIPTLYPALHDPEVFEDAESFIPERWENPTGDMDKRNWLPFGVGPHVCLGQKYVLMLFTG
MLGKFLVGADLVHHKTDLSEEIKVFATIFPKDDLILEFKRRV
>CYP61A1
Candida lusitaniae
78% to CYP61A2
C.albicans
CLUG_04246.1
MSLNSSSPIVDAVSSKALETSSIVARIAETWHSLSWLQIFITFVIGVLSYDQISYQIKKGSIAGPRFKVWPIIGPFLESL
DPKFEEYKAKWDSGPLSCVSIFHKFVVIASTRELARKILSSPKYVKPCVVDVAVKILRPTNWVFLDGKAHVDYRKSLNGL
FSLKALEIYIPVLETYMDKYLDKFVTYDAPRKFFPEFRELLCALSLRTFCGDYITEDQIKEIADNYFRITAALELVNFPI
IIPYTKTWYGKKIADETMKVFEDCAAEAKIHINEKNGKPTCVMDEWIFLMKKARESHAEDSESKLLIREFSNKEISEAIF
TFLFASQDASSSLACWLFQLVADRPDVAAKVREEQMRIRNNDPSVPLSLDLINEMTYTNHVVKEALRYRPPVLMVPYVVK
QPFPVTPEYTAPKGSMVIPTLYPALHDPEVYPDPDSFIPERWENATGDMNKRSWLVFGSGPHVCLGQQYVMMLFTGMLGK
YLMNSEIKHHVTPLSEEIKVFATIFPKDDLILEWEKRDPLSATS
>CYP61A1 Candida dublinensis
96% to CYP61A2 C.albicans
cdub_7-g12.1
MNSTEVDNLPLHEQLTSFVELAIAKATGSPITTLFTIIFLILLYDQLSYQINKGSIAGPRFKFYPIIGPFLESLDPKFEE
YKAKWDSGELSCVSIFHKFVVIASSRDLARKILSSPKYVKPCVVDVAVKILRPSNWVFLDGKQHTDYRRSLNGLFSSKAL
EIYIPVQEKYMDIYLEKFCNYDGPREFFPEFRELLCALSLRTFCGDYITDDQIAVVADNYYRVTAALELVNFPIIIPYTK
TWYGKKIADDSMKVFENCAAMAKKHINENNGTPTCVMDEWIHLMKEAREKHSEDPDSKLLVREFSNREISEVIFTFLFAS
QDASSSLACWLFQIVADRPDVVAKIREEQLRVRNNNPDLRLSLDLINQMTYTNNVVKETLRYRPPVLMVPYVVKKSFPVT
ESYTAPKGAMIIPTLYPALHDPEVYDEPDSFIPERWENASGDMYKRNWLVFGTGPHVCLGKNYVLMLFTGMLGKFVMNSD
MIHHKTDLSEEIKVFATIFPKDDLILEWKKRDPLKSL
>CYP61A1 Candida glabrata CBS138
81% to CYP61A1
S. cerevisiae CAG62657.1
MASVVDQVHMSMNATAHAAGAASAGAVMAAPSLLDKLQGMSYLQMFVTLICGVLVWDQVSYQMKKGNIAGPRFKVYPIIG
PFLESLDPKFEEYKAKWDSGPLSCVSIFHKFVIIASTRDLARKVLQAPKYVKPCVVDVAVKILRPSNWVFLDGKAHTDYR
KSLNGLFTKTALAQYLPPLEELMDKYIEKFVELSKENNYEPQIFFHEMREILCALSLRSFCGDYISEDQIRKIADDYYLV
TAALELVNFPIILPFTKTWYGKRTADMAMKIFESCAQRAKDHIAAGGKPICVMDNWCKLMHDAKNRTDDDSRLLHREFTN
REISEAVFTFLFASQDASSSLACWLFQIVADRPDVLAKIREEQLRVREGDINKRLDIDLVDKMEYTHMVVKETLRYRPPV
LMVPYVVKNKFPVVPDYQAPKGSMLIATLYPALHDPEVYENPDDFIPERWVEGSPANEAKKNWLVFGCGPHVCLGQTYVM
ITMTALIGKFALFTDFKHKVTPLSEKIKVFATIFPKDDLLLSFKKRDPVTGEIKE
>CYP61A1 Kluyveromyces polysporus
Kpol_1056p10
86% to CYP61A1
S. cerevisiae
MSHPDMAMAINNNLNNMTSIDSSSLLVSIQSLSYWKIFVTLISVLLVWDQISYQIKKGSIAGPAFKFYPIIGPFLESLDP
KFEEYKAKWDSGELSCVSIFHKFVVIASTRDLARKILQAPKFVKPCVVDVAVKILRPSNWVFLDGKAHVDYRKSLNGLFT
KTALAQYLPSQEEVIDKYMEKFVEYSKKNNYEPQVFFHEMREILCALSLQSFCGDYITEDQIRKIADDYYLVTAALELVN
FPIILPYTKTWYGKRTADAAMKIFESCAQRAKDHIAAGGKPICVMDAWCKLMHDAKDRNDSESRLFHREFSNKEISEAVF
TFLFASQDASSSLACWLFQIVADRPDILQKIREEQMAVRNNDLNTPLTIELIEKMTYTNMVIKETLRYRPPVLMVPYVVK
QKFPVSPNYTAPKGAMLIPTLYPALHDPEVYENPDDFIPERWVEGSKASEAKKNWLVFGCGPHVCLGQTYVLITFAALIG
KFALYTDFKHKVTPLSEKIKVFATIFPKDDLWMSFKRRDPITGEVTE
>CYP61A1 Kluyveromyces lactis
80% to CYP61A1 Saccharomyces kluyveri
KLLA0D11242g
MDNIVVSQTSNATQVASEASVKLFSLANAQQLVETVQQMSYFKLFCTLVAIVIVWDQVSYQIQKGNIAGPKWKVWPVIGP
FLESFDPKFEEYLAKWNSGPLSCVSIFHKFVVIASTRDLARKIFQSPQYVKPCVVDVAVKILRPSNWVFLDGKEHVDYRK
SLNGLFTKQALAKYMPSQELLMDKYIEKFIELSKENKYEARVFFHDMREIMCALSLKAFCGDYITEDQIRKVADDYYLVT
AALELVNFPIIIPYTKTWYGKKTADMTMKIFEQCAQMAKDHIAAGGESTCVLDAWCSLMHEAKNKDDADSKLYHREFTNR
EMSEAIFTFLFASQDASSSLACWIFQIIADRPDVMANIREEQLRVRNNDPNVKLSMDLIDEMKYTNMVVKETLRYRPPVI
MVPYYVKKSFPVVPTYSAPKGSMLIPTLYPALHDPEVYEDPDEFIPERWVEGSAANQAKKNWLVFGCGPHVCLGQTYVMQ
TFTGLIGKFAMFSDWEHKVTPLSEKIKVFATIFPKDDLLLSFKKRDPLTGEVEL
>CYP61A1 Uncinocarpus reesii
75% to CYP61A1 Aspergillus fumigatus
UREG_06546.1
MVNAHANMASPSADASLASMSSDPSSLLMSIYNSFTGWSALLALFMLLVAYDQFKYIWLKGSIVGPRFKIPFMGPFLESV
NPKFTEYKAKWASGDLSCVSVFHKFVVIASTRDMARKVFNSPAYVKPCVVDSAHKLLGKDNWVFLDGKAHVEYRKGLNGL
FTRSALTTYMPQLDEVYDKYFKQFLEESKQNDFKPLPWMPYLRELMCALSCRTFVGHYMTDEAVKKIADDYYLITAALEL
VNFPIILPFTKSWYGKKAADMVLEEFSKCAAKSKVRMAAGGEANCIMDGWVKQMLDSAEYREKIAKGIEVDDSEKPKHLL
RDFTDFEIAQTVFTFLFASQDATSSASTWLFQLMADRPDILDKVREENLAVRNGDRNGKISMDILDKMQYTRAVVRETLR
YRPPVIMVPYMTKKDFPITPNYTLPKGCMIVPSVWPAAHDPEAYPNPETFDPDRWITGDAEKAAKNFLIFGTGPHYCLGQ
TYAQLNLMAMIGKASLLMDWEHHATPISEDIKVFATIFPQDDCPLVFRPRA
>CYP61A1 Histoplasma capsulatum G217B
77% to CYP61A1 Uncinocarpus reesii
ABBT01000205.1 Ajellomyces capsulatus G217B
1837477-1839379 (+)
ABBT01000210.1 Ajellomyces capsulatus G217B
225529- 227431 (+)
Two identical sequences. Note 51F2 also has
two identical sequences
One of them is also on ABBT01000205.1 and the
other is on ABBT01000207.1
HCB06044.1 identical to HCB06499.1
MDTLNGSFASPVADVGLASSVARDPAGLLMSIYNGMTLWTTIFTTLLLLVTYDQVKYIWLKGSIEGPRFKVPFMGPFLQS
VNPKFPEYQAKWASGELSCVSVFHKFVVIASTRDMSRKVFNSPTYVKPCVVDVAHKLLGKDNWVFLDGKEHVEFRKGLNG
LFTRAALTNYMPQLEDVYDRFYNMFVQRSEELNMKPEPWMPHFRELMTALSCRTFVGHYMSDEAVKHVADDYYLITAALE
LVNFPIIIPFTKTWYGKRSSDMVLREFTKCAAKSKVRMAKGEKVTCIMDSWVKNMLDSAAYREKIAKGLPVEDSEKPAHI
LRDFTDYEIAQTIFTFLFASQDATSSASTWLFQLLSDRPEILDKVREENLRIRGGDRNVPISMELLDQMDYTRAVVRETL
RYRPPVIMVPYMVKKDFPVTDTYTLPKGSMIIPSVWPSTHDPEAYPDPETFNPERWLNGEADKAAKNFLVFGTGPHYCLG
QTYAQLNLMAMIGKASMLLDWEHHTTPTSEDIRVFATIFPEDDCPLVFRRRPE
>CYP61A1 Coccidioides immitis
90% to CYP61A1 Uncinocarpus reesii
CIMG_05009.2
MASVAGNMASPSADASLASMASDPSSFVMGIYSRFTGWSALLALFMFLVAYDQIKYIWLKGSIVGPRFKIPFMGPFLESV
NPKFTEYKAKWASGELSCVSVFHKFVVIASTRDMARKVFNSPAYVKPCVVDSAHKLLGKTNWVFLDGKEHVEYRKGLNGL
FTRSALSVYMPQLDDVYEKYFKLFLEESKKNNFKPIPWMPYLRELMCALSCRTFVGHYMTEAAVKKIADDYYLITAALEL
VNFPIILPFTKSWYGKKAADMVLDEFSKCAAKSKVRMAAGGEVTCIMDAWIKQMLDSAKYREKIAKGIQVDDSEKPSHIL
RDFSDYEIAQTVFTFLFASQDATSSASTWLFQLMANRPDVLDKVREENLAVRNGDRNGKITMDLLDQLQYTRAVVRETLR
YRPPVIMVPYMTKKDFPITPNYTLPKGCMIVPSVWPATHDPDAYPNPETFDPDRWISGDADKAAKNFLVFGTGPHYCLGQ
TYAQLNLMAMIGKASMMMDWEHHATPISEDIKVFATIFPQREPIRDIPTFVALL
>CYP61A1 Mgr052 Mycosphaerella graminicola
67% to CYP61A1 A. oryzae
MASVMQALNASSTDAPNPLYVDIAVASPGLVNKIFDSATPVNVFGAFLALFVAAVIYDQCSYWTHKGTLAGDAWKIPFVG
PFLESVNPQFSKYHQKWLSGALSCVSVFHKFVVIAATRDMARKVLNSPAYVKPCVVDVAHKLLRPENWVFLDGKEHVEYR
KGLNGLFTRTALETYLPGQEEVYNEYFEEFLRESQAAGKPKAWVYYLRELMCAVSCRTFVGHYMSREGVKKIADDYYNIT
AALELVNFPIILPFTKTWYGKKASDKVLEAFANCAAKARIRMKQKGAQPECIMDRWLMQMIESDRYRERIANGEKVPQEE
KPAMLLRNFSDLEISMTVFTFLFASQDATSSAASWMLQLVADRPEVLQKVREEGHRLRPDPNHPVSLETLEKMEYTRAVV
KETLRYRPPVLMVPYLVKKDFPIPEANYVAKKGTMIIPSTWLSLHDPEAYENPDEFAPERWTVGNAEEQGKNWLVFGTGP
HYCLGQTYAVLNLMLMLHKLSKEYEWEHQITDKSEDIRVFATIFPMDDLLLKFKRRDPAMVAAGA
>CYP61A1 Mycosphaerella fijiensis
estExt_Genewise1.C_20563
80% to CYP61A1 Mycosphaerella graminicola
MASVMETFNASATHHPNTIHATIDSLQTGFVSKAFDNFTPVSWFGVFLTIFLAAIVYDQLSYWQHKGPLAGDAWKIPFVG
PFLESVNPKFSAYHTKWLSGPLSCVSVFHKFVVIAATRDMARKVLNSPMYVKPCVVDVAHKLLRPENWVFLDGKEHVEYR
KGLNGLFTRQALENYLPGQEEVYNEYFEDFLRESEAAGEPKPWVYQLREIMCAVSCRTFVGHYMSREQVKRIADDYYLIT
AALELVNFPIILPFTKTWYGKKCADKVLEAFSNCAAKSKVRMRQKGAQPECIMDRWVMQMIASERYRERIAKGEKVPDEE
KPPMLLRNFTDLEISMTVFTFLFASQDATSSACSWMLQVVADRPDVMQKVREEGDRLHPNPNEPISLEILESMQYTRAVV
KETLRYRPPVLMVPYLVKKDFPIPEANYVAKKGSMIVPSTWLSLHDPDVYEQPDEFVPERWTIGDAEEKGNKNWLVFGTG
PHYCLGQTYATLNLMLMLHKFSASYDWKHTKTPTSEEIKVFATIFPMDDLLLTIRRREGVATA*
>CYP61A1 Fusarium graminearum FG01959.1
AACM01000104 FGcontig1.104_scaffold1
MEAVNSTTSGFSSVLAGTKYANVNIPPQIDYVXXXXIEAVSNAGVWTWVFTLVA
LCIAYDQIAYIVRKGPIVGPAMKIPFIGPFLDSMDPRFDGYHAKWSSGPL
SCVSIFHKFVVIASTRDMARKVFNSPAYVKPTVVDVAPKLLGHDNWVFLD
GKAHVDFRKGLNGLFTRKALELYLPGQEEAYNTYFKHFLKMTKDAGGKPV
PFMHEFREVMCAVSCRTFVGHYISDEAVTKIAEDYYLITAALELVNLPVI
LPYTKSWYGKKAADMVLAEFSKCAAKSKVRMAAGGEVTCIMDAWILSMIQ
SERWRKAEEKGEPHNVEKPSPLLRMFNDYEISQTIFTFLFASQDATSSAA
TWLFQVTAQRPDVLDRVREENIKIRNGDPNAPLTMDQLESLTYTRAVVRE
LLRWRPPVIMVPYVTKKAFPLTDDYTVPKGSMLIPTTFMALHDPEVYDNP
SHFDPERYYSGDAEEKGSKNYLVFGTGPHYCLGQVYAQLNLALMIGKASV
MLDWKHHATPKSEEIKVFATIFPMDDCPLTFEERKW*
>CYP61A1
AAIM02000091.1 Gibberella moniliformis 7600
95% TO FUSARIUM
GRAMINEARUM 61A1
99% to 61A1 F.
oxysporum
also Fusarium
verticillioides FVEG_07284
MEAVNATSSGFSSVLAGTKYVNVALPPQVEYVIEAVSNAGVWTWVFTFIALCVAYDQ (1)
350695
IAYIIRKGPIEGPAMKLPFIGPFLDSMDPRFDGYHAKWSSGPLSCVSIFHK (2) 350847
350776
FVVIASTRDMARKVFNSPAYVKPTVVDVAPKLLGHDNWVFLDGKAHVDF 351054
351055 RKGLNGLFTRKALESYLPGQEEAYNTYFKHFLKMTKDAGGKPVPFMHEFREVMCAVSCRT 351234
351235
FVGHYISDEAVTKIAEDYYLITAALELVNLPVILPYTKSWYGKKAADMVLAEFSKCAA 351408
351409
KSKVRMAAGGEVTCIMDAWVLSMIQSERWREAEEKGEGHTVEKPAPLLRMFNDYEISQTI 351588
351589 FTFLFASQDATSSAATWLFQVTAQRPDVLDRVREENIKVRNGDPNAPITMDQLESLTYTR 351768
351769 AVVRELLRWRPPVIMVPYVTKKAFPLTENYTVPK (1)
GSMLI 351948
351949
PTTFMALHDPEVYDNPSHFDPERYYSGDAEEKGSKNYLVFGTGPHYCLGQVYAQLNLALM 352128
352129 IGKASVMLDWKHHATPKSEEIKVFATIFPM 352218
DDCPLTFEERKW*
>CYP61A1 Fusarium oxysporum
99% to 61A1 Gibberella moniliformis
FOXG_04166
MEAVNATSSGFSSVLAGTKYANVALPPQVEYVIEAVSNAGVWTWVFTFIALCVAYDQIAYIIRKGPIEGPAMKLPFIGPF
LDSMDPRFDGYHAKWSSGPLSCVSIFHKFVVIASTRDMARKVFNSPAYVKPTVVDVAPKLLGHDNWVFLDGKAHVDFRKG
LNGLFTRKALESYLPGQEEAYNTYFKHFLKMTKDAGGKPVPFMHEFREVMCAVSCRTFVGHYISDEAVTKIAEDYYLITA
ALELVNLPVILPYTKSWYGKKAADMVLAEFSKCAAKSKVRMAAGGEVTCIMDAWVLSMIQSERWREAEEKGEGHTVEKPT
PLLRMFNDYEISQTIFTFLFASQDATSSAATWLFQVTAQRPDVLDRVREENIKVRNGDPNAPITMDQLESLTYTRAVVRE
LLRWRPPVIMVPYVTKKAFPLTENYTVPKGSMLIPTTFMALHDPEVYDNPSHFDPERYYSGDAEEKGSKNYLVFGTGPHY
CLGQVYAQLNLALMIGKASVMLDWKHHATPKSEEIKVFATIFPMDDCPLTFEERKW*
>CYP61A1 Magnaporthe grisea MG06047.4 51% to 61A1 S.c. 72% to 61A N.c.
AACU01000857 cont2.1129
MASVAVGVANATAAFTSPLASYVPSNVALPPQLEYVLGNVIETVSNAGFW
TILGTVVLMLAIYDQFSYQRSKGNIVGPRFKEPFIGPFLQSMNPKWEEYY
GKWTSGPLSCVSVFHKYAYTFPHSKTVTELLNMPCVVDVAPKLLGHDNWV
FLDGKAHVDFRKGLNGLFTRKALECYLPGQEDVYNRYFKKMVQITKDAGG
KPVPFMVEFREIITAVSCRTFVGHYMSDETVRRIAVDYFYITEALELVNF
PIILPFTKTWYGKKAADMVLAEFSKCAAKSKARMNADGEVTCIMDAWIQQ
MVLSQRWRDAEAAGTITDDMEKPNPLLRDFTDYEIAQTLFTFLFASQDAT
SSAATYMFQIMAQHPEVLDRVREENYNVRNGDINARVSLEQLESMKYTRA
VVKELLRYRPPVIMVPYVTKKAFPITPEYTAPKGSMLIPTTYMALRDPEV
YDRPDEFDPERYYTGDAEEKGQKNFLVFGTGPHYCLGQHYAQLNLALFVG
MASLQLDWKHHATPLSEEIQVFATIFPKDHCPLTFDWRKWN*
>CYP61A1 Nectria haematococca
fgenesh1_pg.scaffold_12000391
Necha1/scaffold_12:1044679-1046547
88% to CYP61A1 Fusarium graminearum
53% to CYP61A1 S. saccharomyces
This gene model seems correct DRN 2/6/06
MASVNSTGGFTSVLANSKYANVGIPPQLDFVIDAVSNAGIWTWIATIVAVCVVYDQ
(1)
ISYIMQKGSLVGPSWKMPFIGPFLDSMDPRFDGYHAKWESGPLSCVSIFHK
(2)
FVVIASTRDMARKVFNSPGFVKPTVVDVAPKLLGHDNWVFLDGKAHVEFRKGLNGLFTRKALESYLPGQE
ESYNTYFKHFLQMTQEAGGKPVPFMHEFREVMCAVSCRTFVGHYISDEAVKKIAHDYYLITAALELVNLP
VILPWTKSWYGKKAADMVLHEFSKCAAKSKVRMAAGGEVTCIMDAWVLAMVQSQRWREADEKGEADGMEK
PTPLLRMFNDYEISQTIFTFLFASQDATSSAATWLFQVTAQRPDVLDRVREENIKVRNGDPNAAVTMDQL
ESLTYTRAVVRELLRYRPPVIMVPYVTKKAFPITDSYTVPK (1)
GSMLIPTTYMALHDPDVYENPDYFDPDRYYKGDAEEKGAKNYLVFGVGPHYCLGQVYAQLNL
ALMIGKASVMLDWKHHATPKSEEIKVFATIFPM (0)
DDCPLTFEERKW*
>CYP61A1 Aspergillus nidulans AN4042.1 66%
to 61A1 51 clan revised
MAEINGSFVSPAADATVFPQVFQPAGLIADFLNGLTLWKTLATLFALAVV
YDQFRYIYLKGAIVGPAWKLPFMGPFLQSVNPKFHEYKAKWDSGELSCVS
VFHKFVVIASTRDMSRKIFNSPTYVKPCVVDAAHKLLGKTNWVFLDGKEH
VDFRKGLNNLFTRQALSCYLPRMEEVYNDYYARFLKKSKNNNYKPTPWMP
EFRDLMCAVSCRTFVGHYISDEAIDKISVDYYNITAALELVNFPIILPFT
KTWYGKKAADMVLDEFAKCAAKSRARMAAGGEISCIMDAWIKAQLDSAKY
REKIAKGIEVDSSEKPPQVLRDFTDYEVSQTIFTFLFASQDATSSACTWL
FQLMADRPEILDKVREENLRLRNGDVNAPLTMDLLDSMTYTRAVVKETLR
YRPPVIMVPYIAKKDFPITDKITVAKGSMIIPSVYPATRDEEAYPNADSF
DPDRWITGTAEQHPKNFLIFGTGPHYCLGQTYAVLNLMAMIGKASMEMDW
VHTPTPQSEEIKVFATIFP (0)
DDCLLTFRPRA
>CYP61A1 Aspergillus oryzae
AP007155.1
MANVTGSFVSPSADATVVPQLFQPSGLLGSLLGDFNVWKGLLTLFIAAVIYDQ (0?)
FRYFYQKGSIVGPRWKLPFMGPFLQSVNPKFHEYKAKWDSGELSCVSVFHK (2?)
FVVIASTRDMSRKIFNSPAYVKPCVVDSAHKLLGEDNWVFLDGKDHVEFRKGLNGL
FTRSALSCYLPRQEETFNQYFKHFLEKSKANGYKPTPWMPEFRELMTAISCRTFVGHY
MTDEVIQKINDDYYLITAALELVNFPIILPFTKTWYGKKAADMVMEEFAKCAAKSKAR
MAAGGEVSCIMDAWVKAQQVSAKYREDVAKGIPAEKPPQLLRDFTDEEIAKTVFTFLF
ASQDATSAASTWLFQLMADRPEVLEKVREENVRLRNGDINAPITMELLDQMEYTRAVV
KETLRYRPPVIMVPYLVKKDFPITEKITVLKGSMIIPSVWPATHDEEAYPNPDTFDPD
RWITGTAEQNPKNWLVFGTGPHYCLGQTYAQLNLMAMIGKASMEMTWEHTTTPKSEDI
KVFATIFPQ (0)
DDCLLTFRPRA
>CYP61A1 Aspergillus flavus
100% to CYP61A1 Aspergillus oryzae
AFL2G_02074
MANVTGSFVSPSADATVVPQLFQPSGLLGSLLGDFNVWKGLLTLFIAAVIYDQFRYFYQKGSIVGPRWKLPFMGPFLQSV
NPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPAYVKPCVVDSAHKLLGEDNWVFLDGKDHVEFRKGLNGL
FTRSALSCYLPRQEETFNQYFKHFLEKSKANGYKPTPWMPEFRELMTAISCRTFVGHYMTDEVIQKINDDYYLITAALEL
VNFPIILPFTKTWYGKKAADMVMEEFAKCAAKSKARMAAGGEVSCIMDAWVKAQQVSAKYREDVAKGIPAEKPPQLLRDF
TDEEIAKTVFTFLFASQDATSAASTWLFQLMADRPEVLEKVREENVRLRNGDINAPITMELLDQMEYTRAVVKETLRYRP
PVIMVPYLVKKDFPITEKITVLKGSMIIPSVWPATHDEEAYPNPDTFDPDRWITGTAEQNPKNWLVFGTGPHYCLGQTYA
QLNLMAMIGKASMEMTWEHTTTPKSEDIKVFATIFPQDDCLLTFRPRA
>CYP61A1 Aspergillus fumigatus Af293
GenEMBL
XP_750145.1, NZ_AAHF01000007
cytochrome P450
sterol C-22 desaturase
81% to 61A1
Aspergillus oryzae
MANVNGSFVSPSADATISPQLFYNVDSLSAVLNGFTFWKALATLFFAAVIYDQLRYFYLKGSLVGPTFKL
PFMGPFLQSVNPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPAYVKPCVVDIAHKLLGPD
NWVFLDGKEHVEFRKGLNGLFTRSALSSYLPVMEECYNKYYKYFLEKSKANDYKPEPWMPEFRELMCAVS
CRTFVGHYMTDAAIKKIADDYYMITAALELVNFPFILPFTKAWYGKKASDMVLEEFSNCAAKSKAHMAAG
GEITCIMDAWVKAQQDSAKYNEKIAKGLPVEDSEKPSHLLREFTDYEIAQTVFTLLFASQDATSAACTWL
FQLVADRPDVLEKIREENLRVRNGNINAPLTMDLLDEMKYTRAVVRETLRYRPPVIMVPYLVKKDFPITD
SITVSKGSMIIPSVWPATHDPEAYPNPDSFDPDRWITGDAEKQAKNFLVFGTGPHYCLGQTYAQLNLIAM
IGKASLEMDWEHAPTPKSEDIKVFATIFPE (0)
DDCHLTFRPRA*
>CYP61A1 Neosartorya fischeri
99% to CYP61A1 Aspergillus fumigatus =
ortholog
NFIA_020740
MANVNGSFVSPSADATISPQLFYNVDSLSAVLNGFTFWKALATLFFAAVIYDQLRYFYLKGSLVGPTFKLPFMGPFLQSV
NPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPAYVKPCVVDIAHKLLGPDNWVFLDGKEHVEFRKGLNGL
FTRSALSSYLPVMEECYNKYYKHFLEKSKANDYKPEPWMPEFRELMCAVSCRTFVGHYMTDAAIKKIADDYYMITAALEL
VNFPFILPFTKAWYGKKASDMVLEEFSNCAAKSKAHMAAGGEVTCIMDAWVKAQQDSAKYNEKIAKGLPVEDSEKPSHLL
REFTDYEIAQTVFTLLFASQDATSAACTWLFQLVADRPDVLEKIREENLRVRNGNINAPLTMDLVDEMKYTRAVVRETLR
YRPPVIMVPYLVKKDFPITDSITVSKGSMIIPSVWPATHDPEAYPNPDSFDPDRWITGDAEKQAKNFLVFGTGPHYCLGQ
TYAQLNLIAMIGKASLEMDWEHAPTPQSEDIKVFATIFPEDDCHLTFRPRA*
>CYP61A1 Aspergillus clavatus NRRL
NZ_AAKD03000006.1
87% TO ASPERGILLUS FUMIGATUS CYP61A1, 52% TO
CYP61A6 A. clavatus
ACLA_030640
468671
MANINGSFVSPSADATLSPQFFQSAEFLPAILNGFTIWKALVTLFIAAVIYDQ (1) 468513
LRYFYLKGSLVGPTFKLPFMGPFLQSVNPK 468315
468314
FHEYKAKWDSGELSCVSVFHK (2)
FVVIASTR 468135
468134
DMSRKIFNSPAYVKPCVVDVAHKLLGADNWVFLDGKDHVEFRKGLNGLFTRSALSCYLPE 467955
467954
MEECYNQYYKRFLKKSKANQYKPEPWMPEFRELMCAVSCRTFVGHYITDEAVQKIADDYY 467775
467774
MITAALELVNFPFILPFTKAWYGKKASDMVLQEFSNCAAKSKARMAAGGEISCIMDAWVK 467595
467594
SQLDSAKYREKIANGVPPEEAGKPSHLLRDFTDYEIAQTIFTFLFASQDATSAACTWLFQ 467415
467414
LMADRPEILDKVREENVRVRNGDITAPLSMDLLDQMTYTRAVVKETLRYRPPVIMVPYLV 467235
467234
KKDFPITDSVTVAKGSMIIPSVWPATHDPEAYPNPDSFDPDRWITGDADKHPKNWLVFGT 467055
467054
GPHYCLGQTYAQLNLMAMIGKASMEMDWVHTPTPESEDIKVFATIFPQ 466911
DDCHLTFRPRA*
>CYP61A1 Aspergillus niger
estExt_GeneWisePlus.C_12230|Aspni1
84% to CYP61A1
MASVNGSFVSPSADAVVSPRLFEPTGLVASVLEGFTVWKALLTLFVAAVIYDQFRYLWLKGSIVGPAWKLPFMGPFLQSV
NPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPTYVKPCVVDVAHKLLGADNWVFLDGKDHVEFRKGLNGL
FTRQALSFYLPRMEEVYNEYYARFLRISKENNFKPTPWMPEFRELMCAVSCRTFVGHYITEEAIQKIADDYYMITAALEL
VNFPFILPYTKAWYGKKAADMVLAEFSNCAAKSKARMAAGGEISCIMDAWVKAQQDSAKYREKIAQGIAVEASDKPAQVL
RDFTDYEIAQTVFTFLFASQDATSAASTWLFQLMADRPDVLDKVREENLSVRNGDIKAPLTMELLDQLPYTRAVVKETLR
YRPPVIMVPYLVKKDFPITENVTVSKGSMIIPSVWPACHDEEAYPNADSFDPDRWITGTAEQQTKNWLVFGTGPHYCLGQ
TYAQLNLMAMIGKASMEMDWEHTPTPESEDIKVFATIFPQDDCLLAFRPRP*
>CYP61A1
Aspergillus terreus
87% TO CYP61A1
Aspergillus niger
70% to CYP61A1 Aspergillus
terreus
55% to CYP61A6
Aspergillus terreus
ATEG_03815.1
MATVNGSFVSPSADATIVPQLFAPSGLIGSVLEGFTVWKALLTLFLAAVIYDQLRYFWLKGSIVGPAMKLPFMGPFLQSV
NPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPAYVKPCVVDAAHKLLGADNWVFLDGRDHVDFRKGLNGL
FTRQALSCYLPRMEEVYNDYYARFLKKSKDVNYKPVPWMPEFRELMCAVSCRTFVGHYITDEAVQKIADDYYLITAALEL
VNFPIILPYTKTWYGKKAADMVLEEFSKCAAKSKARMAAGGDISCIMDAWVKQQLDSARYRENVAKGVPVDENEKPAQVL
RDFTDYEIAQTIFTFLFASQDATSAACTWLFQLMADRPEVLDKVREENLRVRNGDVNAPLTMDVLESLTYTRAVVKETLR
YRPPVIMVPYLVKKDFPVTDKITVSKGSMIIPSVWPATHDEEAYPNADSFDPDRWITGTAEQQSKNWLVFGTGPHYCLGQ
NYATLNLMAMIGKASMEMNWEHTPTPQSEDIKVFATIFPQDDCLLTFRPRA
>CYP61A1 Ustilago maydis
GenEMBL XM_397965.1 in the 61 clan 49% to
CYP61 N.crassa
MASILGVGQQGLNFSRSSAPSSPLIPRDSALGKVFSIVDLTRLPSLQEADRTTVVFTILAVVATLLLAEQ
YTYQKKKAGLPGPKWTIPVIGKFADSLHPTLEKYQEGWNSGPLSVASVFNIFIVIASSNEYTRKILNSPT
YAEPCLVASAKKVLCPDNWVFLNGKTHVDYRRGLNTLFTRQALGIYLGIQETIYKRYFEEWLADTNPNPQ
PYMMKFRDLNMETSLRVFCGNYIPDEGAKQISDNYWLITVALELVNFPFAFPGTKVYNAIKARKTAMKWF
ELTARESKKRMAAGEEVTCLTDAWIKAMVDARLQRDNADLEAETRRVLLRDFSDREIGMVLLSFLFASQD
AMSSGLTYLLQHVADRPDVLRKVREEQYRVRGDDINAALTYNAIEQMEYTKAVVKESLRIKPPVIMVPYL
TQKDFPIDKNYTVPKGSMVIPSFWNSLHDEKVYPQPDEFKPERWLDEADPANKSPKNYLVFGSGPHYCIG
QQYANMHLTAVLGTASVLMNWEHEVTPLSEKVEVIATIFPKDGARIKFSRRAAPAPGTAPEVAARA
>CYP61A1 Sporobolomyces roseus
57% to CYP61A1 Ustilago maydis, estExt_fgenesh1_pm.C_40050
MASTPHLSAQVAAASESPLFGKLAPSFDKLNIEWSTQTIATSVLAVIVTLLIAEQTLWRYRKSTLPGHSWQIPVIGQFAE
SLNPTMEAYKRSWSTPLASVSFIVIASTTEYARKILNSSTLAEPCLVRSAKQILLPENWVFLNGKVHNEYRKGLNCLFTP
QALEIYLKKQDQIYRNHFRAWLSDPNPNAQPYQLKFRDLNMETSLKVFCGDYISDKNAKEVSEKYWQITQALELVNFPFA
FPGTKVWSACRAREVTVKYLAQAAAASKKAVAAGKEPDCLLDEWVEEIHAGKVRKYEDKEMALVLLSFIFASQDAMSSSI
TFAFQLLADHPEVLAKVREEQAAVRHGDYETPMTLALLEQMPYTNAVTKEVLRYRPPVIMVPYMTKKPFPINEEYTVPKG
TMLIPSFWNSLHDEKVYPDAEEFIPERFMPGGVNDNDKDAKNWLVFGAGAHRCIGQNYVYMHMTAVIGSAAMLMNWEHAK
TPESEEIQIIATLFPKDGCHLKFTPREEAATAL
>CYP61A1 Malassezia globosa
74% to CYP61A1 Ustilago maydis, MGL_0310
MSHGQSQQVWDTAMTGNETIPQHTLNTATAQEGFTAVQVAFAVLTVIVSLLALEQMVYRMKKGGLPGSKWTIPIIGKFKD
SLNPTLEKYQESWNSGALSVASVFNIFIVIASSTDYTRKILNSPTYAEPCLVASAKKVLCHDNWVFLNGKTHVDYRKGLN
TLFTSRALSIYLNIQENIYKKHFAKWVALGSKDAEAFMLPLRNLNLETSLRVFCGNYISDEGAQQISDEYWLITMALELV
NFPFAFPGTKVYRAIQARKNAMKWFEHTAAESKKRMALGEEVTCLTDAWVKAMLDAREDRQNDDLGAEQRRILVRDFSDR
EIGMVLLSFLFASQDAMSSGLTYLFQHLADHPDVLRKVREEQYAIRNNDIDAPLTIDMIEKMTYTRAVVKESLRLKPPVI
MVPYMARQPFPISETYTAPKGSMVIPSFWNSLHDPTAYPSPDEFRPERWLEGAESPAAKHPKNYLVFGSGPHNCIGKEYA
MQHLIAVMGDASVLLNWEHKRTELSEKVMVIATIYPKDGAYLKFTQRPAPPMDAPAAVAAAM
>CYP61A1 Chaetomium globosum CBS 148.51
NZ_AAFU01000895.1 AAFU01000895.1
84% TO N. CRASSA 61A1
MAANATTSPLATIKYGAASVAPQLEYVIDYVSNASTLSILATILATLVVYDQ (1)
6856
FRYILNKGSIAGPAWKMPFIGPFLQSMNPKFEEYYAKWLSGPLSCVSVFHK (2) 7008
7135
FVVIASTRDMARKVFNSPAFVKPCVVDVAHKLLGADNWVFLDGKAHVEF 7215
7216
RKGLNGLFTRRALEIYLPGQEEVYNRYFKEFVATTKQAGGEPVPFMTHFREVITAVSCRT 7395
7396
FVGHYITDEAVKKIADDYYLITAALELVNFPIILPYTKTWYGKKAADMVLAEFAKCAA 7569
7570
KSKARMAAGGEPNCIMDAWIIQMIQSQRWRDAQAKGDTEGVEKPTHILRDFTDYEISQTV 7749
7750
FTFLFASQDATSSAATWLFQIMAQRPDVLDRVREENLNVRNGDINAAVNMDQLESMTYTR 7929
7930
AVVRELLRYRPPVLMVPYVVKKPFPITETYTAPK (1)
GSMVIPT 8109
8110
TYMALRDPEVYDRPDEFDPERYYTGDAEVKGMKNYLVFGTGPHYCLGQQYAQLNLALMVG 8289
8290
KASLLLDWKHHATPKSEEIKVFATIFPM
8373
DDCPLTFEDRKW*
>CYP61A1 ug.78.18.1(CYP61)
Phanerochaete chrysosporium
MASSQAAFPSTLSDSSRHSTDSPAFIGLLPTGSWFYTTAAILLSLLVIEQSVYRYKKRHLPGDKWTIPLIGKFADSMKPTMEGYMKQWNSGALSAISVFNVRFIVMASTTEYARKILNSPTYAEPCLVHSAKQIILPDNWVFLTGKEHVEYRRGLNLLFTRKALGYVLQYCLVLYAMLTHRRSLYLGIQDVITRKHFAKWLADAAKDPSAKPIMMTARELNMETSLRVFCGNHIPEHGAKEISDKYWMITVALELVNFPLAIPGTKVYNAIQARKAAMKWLELAARKSKESVAAGNPPECMLEEWVTILNDPAYKGRREFSDHEMAMVVFSFLFASQDAMSSGLIYGFQHLADHPEVLAKVREEQERVRGGDYEKPLTLEMMDEMPYLRAMVKETLRVKPPVTMVPYKTTKAFPISQDYTVPSGSMVIPSFYNSLHDPAVFPDPDRFMPERWLDPNGSANTNPRNYLVFGSGPHKCIGLEYAMMNIALVLANAAVLMNWEHELTPQSDKVQIIATLFPQDGCKLKFSPRQHA
>CYP61A1
Cryptococcus neoformans var. neoformans B-3501A
chromosome 6
61% to CYP61A1 Ustilago maydis
AAEY01000030
CNBF1100"
ESTs gb|CF191501.1|CF191501,gb|CF188802.1|CF188802,
gb|CF194425.1|CF194425
EAL20298.1
MESHTVLRPTAIPDLAAIKTWGLEGLTKAKFSFDTKTTTATILT
LILSLLVLEQLVYRAKKAHLPGAKWTIPVIGKFADSLNPTLANYKAQWNSGPLSAVSV
FNIFIVIGSSNEMARKILNSPNHAEPCLVASAKKVLLPENWVFLHGKVHADYRKALNV
LFTKQALSIYLPIQEKIYRSYFNKWMSDPAPAQQYMMKMRDLNMDTSLSVFIGPYLTE
AQKQEINDKYWLITISLELVNFPLAIPGTKVYNAIQARKIVMKYLSAASAASKIRMED
DDAEPECLLDHWVRAMILARRAKDDGEQTRLLSREYSDHEIAMVLLSFLFASQDAMSS
ALVYTFQLTADHPEVLEKVREEQYRVRGNDLERPLTLDMLDDMVYTRATIKEVLRFRP
PVIMVPYMTTKPFPVSPEYTAPKNSMIIPAFWNSLHDETCYPEPDRFLPERWLPQADG
SAPIADSKPQNYLVWGSGPHKCIGGQYASMHLAATLGTASVLMDWKHERTELSDEVQV
IAAIFPKDHCLLKFTPRAPPS
>CYP61A1 P450-10_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
65% to P450-8 = CYP61 C-22 sterol desaturase
53% to CYP61A3 S. pombe
RO3G_04913.1
MSTSPSLFNPRSIESAKNAINSFVKSALNTQPSTTVLVCSALVGLFAYEQYVYLKKKKSLPGPFFKIPIIGAFMDSLYPTFEGYMSKWKSGELSCVSVFDRFVVIASTCELSRKILNAPAYAEPAVVDSMRHILCADNWVFLSGKAHVDYRKGLNVLFT RKALGIYIPIQERVYQKHFDEWLSLDGKSEQYQLRFREINMEASLRVFLGDYMSDQVAQQISEEYFNITAALELVNFPIPLPGTKVYKAIQSRKFIVKHFIECIKDCRIRMAQGGEVKSMMDAWISSMAEYEVECEKAGKPAPRKFDDREVALTILTFLFASQDATSSALTWAFQLLADHPDVLEKVYQEQLRLRKDNLQQELSLELMEESTYLRQVVKEILRLRPPVLMVPYQTVREWPITPSYTIPKKAMVIPTTYPALHDPVAYPNPDAFDPDRWGPEGIAEKHPKNFMVFGNGPHHCLGKEYAVMHLMAVIAQATLQMEWTHTRTEKSDDISIFATIYPQDGCIMSFKPRTITN
>cyp61A1 Phycomyces blakesleeanus (Zygomycete
fungus, Mucoromycotina)
81% to CYP61A8 Rhizopus oryzae, 80% to CYP61A1
Rhizopus oryzae
e_gw1.3.127.1
MKTAFSQPNISTTAVICSAVVGLFAYEQYVYLNKKKGLPGPQFKIPIIGAFTDSLYPTFEGYMSKWKSGELSCVSVFDRF
VVIASTCDLSRKILNAPVYAEPAVVDSMKHILCADNWVFLSGKSHVDYRKGLNVLFTRKALGIYIPVQDKVYKKHFAEWL
SLNGEKGQYQLRFRELNMESSLRVFLGDHMSDEVASKISQEYFNITAALELVNFPIPLPGTKVYKAVQSRKYIVNQFVEC
IKDCRTRMANGGETKSMMDAWVRSMLDTEAELAAAGKPAPRKFDNREIALTILTFLFASQDATSSAMTWAFQLTADHPDV
LHKIRSEQMKLREENPDQELTLELMEKSVYLRQVIKEVLRIRPPVLMVPYQTVREWPITPNYTVPKGSMVIPTTYPALHD
PVAYPNPDNFDPDRWGTEGTAEKYPKNFMVFGNGPHHCLGKEYAVMHLMATLAEACMVLDWTHYRTDKSDDISIFATIYP
QDGCIMSFEPRKSPASIST*
>CYP61A2 C.albicans AL033396 comp(39932..41485)
gene="Ca35A5.10c" 68.9% identical to 61A1
orf19_5178
MNSTEVDNLPFQQQLTSFVELAVAKATGSPITTLFTIIFLILSY
DQLSYQINKGSIAGPRFKFYPIIGPFLESLDPKFEEYKAKWDSGELSCVSIFHKFVVI
ASSRDLARKILSSPKYVKPCVVDVAIKILRPTNWVFLDGKQHTDYRRSLNGLFSSKAL
EIYIPVQEKYMDIYLERFCKYDGPREFFPEFRELLCALSLRTFCGDYITEDQIALVAD
NYYRVTAALELVNFPIIIPYTKTWYGKKIADDTMKIFENCAAMAKKHINENNGTPKCV
MDEWIHLMKEAREKHSEDPDSKLLVREFSNREISEAIFTFLFASQDASSSLACWLFQI
VADRPDIVAKIREEQLRVRNNNPDVRLSLDLINEMTYTNNVVKESLRYRPPVLMVPYV
VKKSFPVTESYTAPKGAMIIPTLYPALHDPEVYDEPDSFIPERWENASGDMYKRNWLV
FGTGPHVCLGKNYVLMLFTGMLGKFVMNSDMIHHKTDLSEEIKVFATIFPKDDLILEW
KKRDPLKSL
>CYP61A3 S.
pombe Z98974 join(10345..10419,10514..12001) gene="SPAC19A8.04" 51%
identical to CYP61A1
MEPSDQIIRFNDKFTTISYLPWILIMQKGHIPGPRFKIPFMGSF
LDSMKPTFEKYNAKWQTGPLSCVSVFHKFVVIASERDLARKILNSPSYVQPCVVDAGK
KILKHTNWVFLDGRDHIEYRKGLNGLFTTRALASYLPAQEAVYNKYFKEFLAHSKDDY
AQYMIPFRDINVATSCRTFCGYYISDDAIKHIADEYWKITAAMELVNFPIVLPFTKVW
YGIQSRKVVMRYFMKAAAESRKNMEAGNAPACMMEEWIHEMIETRKYKSENKEGAEKP
SVLIREFSDEEISLTFLSFLFASQDATSSAMTWLFQLLADHPDVLQKVREEQLRIRKG
DIDVPLSLDLMEKMTYTRAVVKECLRLRPPVLMVPYRVKKAFPITPDYTVPKDAMVIP
TLYGALHDSKVYPEPETFNPDRWAPNGLAEQSPKNWMVFGNGPHVCLGQRYAVNHLIA
CIGKASIMLDWKHKRTPDSDTQMIFATTFPQDMCYLKFSPFDASTVDWKNSKEAFSNE
AVSAATVETESA
>CYP61A1 Schizosaccharomyces japonicus
80% to S. pombe CYP61A3 (misnamed, should be
CYP61A1) SJAG_03249
MTKVSFVVATFSFESLSYQIQKGTIPGPIVKIPFMGSFLDSMKPTFEKYHTKWMSGPLSCVSVFHKFVVIASEREMSRKI
LNSPNYVQPCVVDAGKKILKPNNWVFLDGKAHVEYRKGLNGLFTRRALANYLPAQEAVYNKYFKEFLDYSKDDYKQYMIP
FRDINVAVSCRTFCGSYISDDAITEIADHYWRITAAMELVNFPIVLPFTKIWYGIKARDVVMKFFMNAAAQSRKNMEAGK
PITCMMDEWIHEMIEAREYKEKGAAEGAEKPSILIRDFSDEEISLTFLSFLFASQDATSSAMTWLFQMLADNPEVLRKVR
EEQISIRNGDPKAPITIDLVDKMEYTRWVVKECLRLRPPVLMVPYRVKKGFPIRSDYTIPKDSMVVPTLWCALHDPEVFP
EPDNFIPERWGPEGTAEKSPKSWLVFGTGPHVCLGQRYAVMHLIACIGKASIELDWKHKRTEDSDTQMIFATTFPQDMCY
LKFSPFDSTKLWNELRHKKHEKPEKHEGHDLQREQSINTVASSTTESLAEGLTQTVTEA
>CYP61A1 Schizosachharomyces octosporus
SOCG_00808
MNQTESFLSGSQNVVRLMGYEVEYTRWTVCFALLLVCIAYDQIAYQLRKGNLPGPLIKIPFMGSFLDSMKPTFEKYKTKW
DSGPLSCVSVFHKFVVIASERDLARKILNSPSYVQPCVVDAGKKILKHTNWVFLDGRDHVEYRKGLNGLFTTRALGVYLP
AQEEVYNKYFKEFLDHSQGKYTEFMIPFRDINVATSCRTFCGHYISDDAIKHIAEEYWNITAAMELVNFPLVLPFTKVWY
GIRSRKIVMQYFMKAADASRKSMEAGNAPTCMMEEWIREMIETRKYNNSKGLDGSEKPSVLIRDFSDEEISLTFLSFLFA
SQDATSSAMTWLFQYLADYPEILQKVREEQFRIRDGDPNVPISLELLEKMTYTRMVVTECLRLRPPVLMVPYRVKKSFPI
SPEYTVPKDSMVIPTLYGALHDPKVYPDPESFKPERWEPNGLAQQNPKNWMVFGNGPHVCLGQRYAVNHLIACVGKASLM
LDWSHKRTVDSDTQMIFATTFPQDMCLLKFTPFNPATIKLHLKEDAELQTPTAAGIPSSA
>CYP61A4 Botrytis cinerea (a plant-pathogenic fungus
infecting over 200
plant species)
GenEMBL AL111744 AL111746
Bitton,F., Levis,C., Fortini,D., Pradier,J.M. and Brygoo,Y.
58% to S. pombe 61A3, 77% to 61A1 N. crassa
note: most fungi have only one CYP61 gene
so this is probably the ortholog of CYP61A1
but for historical reasons it was named CYP61A4
EVLDKVREFTDFEIAQTVFTFLFASQDATSSAATWLFQVMAQRPEVLDKVREENLRVRGG
DKRVRPNMDMMESMKYTRAVVRELLRWRPPVLMVPYVAKKAFPITPDYTVPKGAMIVPTT
YPALRDPDVYDRPDEFDPERYFSGDAEVKGAKNYLVFGTGAHYCLGQEYAQMNLALMIGK
ASMELDWVHHPTPKSEEIKVFATIFPMDDCPLTFTKRS*
>CYP61A5 Neurospora crassa
Neurospora crassa sequence contig 1.384 (supercontig 48)
note: most fungi have onlt one CYP61 gene
so this is probably the ortholog of CYP61A1
but for historical reasons it was named CYP61A5
AABX01000229.1 cont3.300 NCU05278.1 (version3)
MASNATSFTSPLASAKLGTVAVPPQLEYVIDTISQASGWTIVFT
LLAVLVAWDQ (1)
24057
24127
IKYVLNKGTIAGPSWKIPFIGPFLESLDPKFEEYYAKWLSGPLS
CVSVFHK (2)
24279
24350
FVVIASTRDMARKVFNSPSYVKPCVVDVAHKLLGADNWVFLDGPA
HVEFRKGLNGLFTRRALEIYLPGQEEVYNRYFKSFLEITKNAGGKPVPWM
PHFREVITAVSCRSFVGHYISDEAVKKIADDYYLITAALELVNFPIIIPY
TKTWYGKKAADMVLAEFAKCAAKSKVRMAAGGEATCIMDAWIKQMIDSKK
WREAVASGNTEGLEKPTHLLRDFTDYEISQTIFTFLFASQDATSSAATWL
FQIMAQRPDVLDRVREENLKVRNGDIHAPINMEQLESMTYTRAVVRELLR
YRPPVLMVPYLVKKAFPITEDYTIPKGSMVVPTTYMALRDPEVYPNPDYF
DPERYYSGDAEAKGAKNYLVFGVGPHYCLGQHYAQLNLALFVGKASLLLD
WKHHPTPLSEEIKVFATIFPK
(0) 25597
25660
DDCPLTFEERKW* 25698
>CYP61A6 Fusarium graminearum FG03686.1
AACM01000161 FGcontig1.161_scaffold2
MASLLDCGAGLASANASFSTATDLSQENGLFSSWFERCSKTQIAVTIFAV
LIAYDQFMYIWRKGSIAGPAFKIPFMGPFIQALYPKFDAYLAQWASGPLS
CVSVFHKFVVLASDRDIAHKVFKSPTFVKPCIVPMAETLLRPSAWVFLQG
RAHTEYRRGLNGLFTNKAISTYLPAQEKVYDDYFERFVAASEANKSKPMA
FMRLFREINCALSCRTFFGDYISQDAVEKIAEDFYQVTAALELVNVPLSV
YIPFTKCWRGKRTADAVLAEFASCAAACKANMAAGAEPKCIVDQWVLHMM
ESKRYNDRIAAGETGAEKPKNLIREFTDEEIGQTMFTFLFASQDASSSAT
TWLFQILAQRPDVLDRLREENLSVRGGNKETPFELSMLESLPYTNAVIKE
LLRYRPPVIFVPYEATKKFPVTPNYTISKGSMIVPSCYPALHDPQVYPDP
ETFDPERWITGDAESKTKNWLVFGAGAHDCLARKYVPLTMAAMIGKASLE
LDWVHHATSQSEEIRVFATLFPEDECQLVFTRQG*
>CYP61A6 Nectria
haematococca fgenesh1_pg.scaffold_25000074
CYP61A6
Necha1/scaffold_25:197180-198781
79% to CYP61A6 Fusarium
graminearum , only 56% to 61A1 F. graminearum
intron at PKG motif in
fgenesh1_pg.scaffold_12000391 not seen here
MIMDMQGSDVLHNGTLPAAPVPSNGVLTGYLANCSNWQVFFTILLLLMTYDQ
(1)
VAYLIRKGSIAGPRFKIPFMGPFVQALYPKFDAYVAQWASGPLSCVSVFHK
(2)
FVVLASDRDIAHKVFKSPTYAKPCLVPMATEIMGSNAWVFLMGKAHTEYRRGLNGLFSNKALGSYLPVQE
KVYEDYFGKFVEESEAHRGKPTAFMRLFREINCALSCRTFFGDYISQDAVQRIADDFYLVTAALELVNVP
LSIYVPFTKCWKGKRTAQAVLAEFAKCAAACKANMAAGGKPTCIVDQWVLHMMESKRYNERIAAGETGIE
KPTNLSREFTNEEIGSTMFTFLFASQDASSSATTWLFQVLAQRPDVLERLREENLAIRGGDRTRPFELSM
FESMTYTNAVVKELLRWRPPVIFIPYLATRSFPVTPNYTVPKGSMIVPSCYPALHDAKAYPDPETFNPDR
WITGDAEQKTKNWLVFGAGPHDCLARKYVPLTMAAMIGKAALELEWEHHATDRSEEIRVFATLFPM
(0)
DECQLVFKRRE*
>CYP61A6 Aspergillus oryzae
AP007155.1
73% to CYP61A6 Nectria haematococca
MDAKMATEIFNTTSAQPESPQSWAYKTSQLQGALPDFLAEWSAWQYVVTFLVGLVLYDQ (1?)
VLYLKRKGALPGPTFKIPLMGPFIQAIHPTFDGYLRQWASGPLSCVSIFHK (2?)
672882
FVVLASDRDLAHKVFKSPAYAEPCLVPVARDIIGHKAWVFLQGRDHAEYRRGLV 673043
673044
PLFTSRAIATYLPVQERVLDDYYNQFVAATKANQGKPMAFMTLFREINCALSCRTFFGDY 673223
673224
ISDDQVKKIADDFYLATDALDLVNIPLAMYVPFTKTWLGKRTADAVHRVFAECAARCKAN 673403
673404 MAKGATPTCIVDHWVLHMMESNRYRERVAAGETNLEKPKNMIREFTNEEISDTLFTFLFA 673583
673584
SQDASSSATTWLFQILAQRPDVLDKLREENLAARGGDRNKPFDLPMLESLTYTNAVIKEL 673763
673764
LRYKPPVILVPYLATKDFPVTPDYTVPKGSMIIPSCYPALHDPEAYPNPDVFDPERWISG 673943
673944
DAESKTKNWLVFGAGPHDCLARKYVPLSLAGMIGKASLELDWEHHPTPRSEEIRVFATLFPM (0)
674129
DGCNLVFKRRP*
>CYP61A6 Aspergillus flavus NRRL3357
AAIH01000781.1
Only 1 aa diff to 61A6 of Asp. Oryzae, 73% to CYP61A6
Nectria haematococca
AFL2G_02724 100% to CYP61A6 Aspergillus oryzae
MDAKMATEIFNTTSAQPESPQSWAYKTSQLQGALPDFLAEWSAWQYVVTFLVGLVLYDQ
VLYLKRKGALPGPTFKIPLMGPFIQAIHPTFDGYLRQWASGPLSCVSIFHR (2)
6085
FVVLASDRDLAHKVFKSPAYAEPCLVPVARDIIGHKAWVFLQGRDHAEYRRGLV 5924
5923
PLFTSRAIATYLPVQERVLDDYYNQFVAATKANQGKPMAFMTLFREINCALSCRTFFGDY 5744
5743
ISDDQVKKIADDFYLATDALDLVNIPLAMYVPFTKTWLGKRTADAVHRVFAECAARCKAN 5564
5563
MAKGATPTCIVDHWVLHMMESNRYRERVAAGETNLEKPKNMIREFTNEEISDTLFTFLFA 5384
5383
SQDASSSATTWLFQILAQRPDVLDKLREENLAARGGDRNKPFDLPMLESLTYTNAVIKEL 5204
5203
LRYKPPVILVPYLATKDFPVTPDYTVPKGSMIIPSCYPALHDPEAYPNPDVFDPERWISG 5024
5023
DAESKTKNWLVFGAGPHDCLARKYVPLSLAGMIGKASLELDWEHHPTPRSEEIRVFATLF 4844
4843 PM (0)
4838
DGCNLVFKRRP*
>CYP61A6 Gibberella moniliformis
AAIM01002518.1
81% to CYP61A6 Nectria haematococca
also Fusarium verticillioides FVEG_08786
29769
MTSIVSPRHEAAISNASSTLKEDISNG
29688
NGLLSSYLNGYSNAQILLAILVVLIAYDQCMYLWRKGPIAGPAFKIPFMGPFIRALYPKF 29509
29508
DHYLAQWASGPLSCVSVFHK (2)
29456
29396
FVVLASDRDIAHKVFKSPTYAKPCIVPMAETLLRPNAWVFLQGKAHTEYRKGLNGLFVN 29220
29219
KALSTYLPVQEKVYDDYFGRFVAASEANKGKPMAFMRLFREINCALSCRTFFGDYISQDA 29040
29039
VEKIADDFYEVTAALELVNVPLSVYVPFTKCWKGKRTADAVLAEFAKCAAACKANMTSGA 28860
28859
EPRCIVDQWVLHMMESKKYNDRIAAGEEGVEKPRNLIREFTDDEIGQTMFTFLFASQDAS 28680
28679
SSATTWLFQVLAQRPDVLDRLREENLAVRNGNRHQPFELSMLESLPYTNAVIKELLRYRP 28500
28499
PVIFVPYEATKSFPVTPKYTVSKGTLIVPTCYPALHDPQAYPNPETFDPDRWITGDAESK 28320
28319
TKNWLVFGAGPHDCLARKYVPLTMAAMIGKASLELDWVHHATSRSEEIRVFATLFPE (0) 28149
28084
DECQLVFTKRE* 28049
>CYP61A6 Trichoderma reesei
AAIL01000244.1
75% to CYP61A6 Nectria haematococca
MATIIEGSMPISFESTINATQHGTSGLVESLWSSCSAASNWQIAITALLVLVAYDQ (1)
10081 YLYISRKGSIAGPTFKIPLIGPFLQAIYPKFDAYLAQWASGPLSCVSVFHK
(2) 9929
9869
FVVLASDRDLAHKVFKSPTFVRPCLVPMAINIMRPTAWVFLNGKAHAEFRRGLTGLFTN 9693
9692
KALSTYLPVQEKVYADYFNRFVEHSKANGGKPTKFMGWFREINCALSCRTFFGDYISQEA 9513
9512
VKRIADDFYLITDALELVNIPLSIHVPFTKCWRGKRTADAVLEEFTKCAAACKVNMASGA 9333
9332
QPTCIVDQWVQHMFESKRYNEAVAAGVEGLEKPTNLIREFSDEEIAQTLFTFLFASQDAS 9153
9152
SSATTWLFQILAQRPDVLDRLRAENLAARGGDKNRPFELEMLESLTYTNAVVKELLRYRP 8973
8972
PVIFVPYLALKPFPVTPDYTVPKNAMIIPSCYPALHDPAAYPNPDVFDPERWITGDAETK 8793
8792
TKNWLVFGAGAHDCLARRYVPLTMAAMIGKASLELDWVHHATERSEEIRVFATLFPM (0)8625
DECPLVFTRRE* 8517
>CYP61A6 Aspergillus terreus NIH2624
AAJN01000026.1
76% to CYP61A6 Nectria haematococca
ATEG_01083.1
MNVKMQADMANSTQPDRQIWHVTTHWQGKVSDSFSGWSACQYIVTILLGVIFYDQ (1)
44968
VMYIKRKGSIAGPTFKMPLMGPFLQAINPKFEEYLAQWASGPLSCVSVFHK (2)45120
45171
FVVLASDRDLAHKVFKSPSYAEPCLVPIAKDILGPKAWVFLQGKAHAEYRRGLTPLFT 45344
45345
NNALATYLPVQDKVFATYFDKFVAASAANNGRPMEFMTMFREINCALSCRTFFGDYISQD 45524
45525
AVKKIADDFYLVTAALELVNIPLSMYVPYTKPWLGKRTADAVHAEFARCAAACKANMASG 45704
45705
AAPTCIVDHWVLHMMESNRYRERVAAGEANVEKPTNLIREFTNEEIGETLFTFLFASQDA 45884
45885
SSSATTWLFQVLAQRPDVLDRVRDENLAARGGDKSKPFDLPMLEGLTYTNAVVKELLRHR 46064
46065
PPVIFVPYLATKNFPVTPSYTVPKGSMIIPSCYPALHDPAVYPDPDVFEPERWISGDAES 46244
46245
KGKNWLVFGAGAHECLAKRYVPLSMAAMIGKAALELDWTHHATERSEEIRVFATLFPM (0) 46418
DGCQLVFRKRS* 46499
>CYP61A6 Chaetomium globosum CBS
AAFU01000675.1 148.51
74% to CYP61A6 Nectria haematococca
796
MAADHVNASSSTPELLMSSSGLASGSSSWQFRDGVVGITAEWSAWQYVITLLLGLVVYDQ (1) 975
1031
VMYLYRKGSITGPRFKVPLTGPFIQALHPKFESYLAQWASGPLSCVSVFHK (2) 1183
1242
FVVLASDRELAHKVFKSPTYTEPCIVPLAKDILGHKAWVFLQGKAHAEYRRGLTPLFT 1415
1416
NKAMATYLPAQEKVFADYFDKFVAASQANVNQPLPFMTLFREINCALSCRTFFGDYISPA 1595
1596
AVKKIADDYYQATAALELVNVPFSIYIPFTKPWRGKRTADAVHAEFAKCAAACKRNMATG 1775
1776
AAPTCIVDHWVRHMFESNRYRERVAAGETDVEKPSNLIREFTDVEISETLFTFLFASQDA 1955
1956
SSSATTWLFQILAQRPDVLDRLREENLAARGGDRNKPFDLAMLESLTYTAAVVKELLRYR 2135
2136
PPVIFVPYLATKAFPITPDYTVPKGAMVIPSCYPALHDPKVYPNPDTFDPDRWITGDAES 2315
2316
KTKNWLVFGAGAHDCLARRYVPLTMAAMIGKAALELNWKHVATEKSEEIRVFATLFPM (0) 2489
DGAQLVFEKRP* 2579
>CYP61A6 Aspergillus clavatus NRRL
AAKD02000011.1
77% to CYP61A6 Nectria haematococca
ACLA_008020
MDTEIANVSRAAAQSGSPQAWT
669433
PQPSSGQNTLLDCLAGWSTWQYLVTFLLGIVVYDQ (1)
669274
VMYLKRKGSIAGPAFKIPLMGPFLQAIHPKFDAYLAQWASGPLSCVSVFHK (2) 669122
669053
FVVLASDRDLAHKVFKSPSYAEPCIVPIAKDIIGHKSWVFLQGKAHAEYR 668904
668903
RGLTPLFTNKAMATYLPVQEKVFTDYFDRFVTASQANRGRPMAFMSMFREINCALSCRTF 668724
668723
FGDYISQKAVKRIADDFYLATAALELVNIPLSMYIPFTKTWLGKRTADAVHVEFAKCAAA 668544
668543
CKANMATGAKPTCIVDHWVLHMMESKRYHERVAAGETDVEKPTNLIREFTNEEIGETLFT 668364
668363
FLFASQDASSSATTWLFQILAQRPDVLDRLREENLAARGGDRNRPFDLPMLESLSYTNAV 668184
668183
IKELLRHRPPVIFVPYLATKNFPVTPDYTVPKGSMVIPSCWPALHDPDVYPNPEVFEPER 668004
668003
WISGDAESKTKNWLVFGAGPHECLAKRYVPLSMAAMIGKAALELEWTHHATEKSEEIRVF 667824
667823 ATLFPM
(0)
DGCQLVFSKRV* 667698
>CYP61A6 Fusarium oxysporum
96% to CYP61A6 Gibberella moniliformis
FOXG_09685 revised
MASIVSPGDEAVVSNASLTFKDDISNSNGLLSSYLNGYSNTQILLTILVVLIAYDQCIYLWRKGPIAGPAFKIPFMGPFI
RALYPKFDHYLAQWASGPLSCVSVFHKFVVLASDRDIAHKVFKSPTYAKPCIVPMAETLLRPSAWVFLQGKAHTEYRKGL
NGLFVNKALSTYLPVQEKVYDDYFGRFVAASEANKGKPMAFMRLFREINCALSCRTFFGDYISQDAVEKIADDFYEVTAA
LELVNVPLSVYIPFTKCWKGKRTADAVLAEFAKCAAACKANMASGAEPRCIVDQWVLHMMESKKYYDRIAAGEEGVEKPR
NLIREFTDDEIGQTMFTFLFASQDASSSATTWLFQVLAQRPDVLDRLREENLAVRNGNRHQPFELPMLESLPYTNAVIKE
LLRYRPPVIFVPYEATKSFPVTPKYTVSKGTLIVPTCYPALHDPQAYPNPETFDPDRWITGDAESKTKNWLVFGAGPHDC
LARKYVPLTMAAMIGKASLELDWVHHATSRSEEIRVFATLFPE
(0)
DECQLVFTKRE*
>CYP61A7 Aspergillus niger
estExt_fgenesh1_pm.C_40133|Aspni1
74% to CYP61A5
MEANSHSFASPLASVRASNLPIPSQFETVVDAVSNASPWTIAFTILAVLVAYDQIIYLINKGNIVGPAFKIPFIGPFLES
VNPKFEEYYAKWTSGPLSCVSVFHKFVVIASTRDLARKVFNSPTYVKPCVVDVAHKLLGKENFVFMDGKPHVDFRKGLNG
LFTKKALQSYLPGQEDVYNQYFERFLGITQKAGGKPVPFMPEFRELMCAVSLRTFCGYYISDEAVKKISDDYYLITEAME
LVNFPIILPFTKAWYGKKASDMVMAEFCQASAKSKVCMAAGKEPTCIMDAWVKNILASKQWVEAEAKGQLAENMEKPSPL
LRDFADWEIAQTVLAFLFASQDATSSAATWLFQTMAQRPDVLDRVREENYKVRNGNVHAEVDMDQLESMTYTRAVVRELL
RYRPPVIMVPYVAKKPFPITDSYTVPKGAMVIPTTYLALRDEEVYEKPDEFDPERYYTGDAEEKGKNNYLVFGTGPHVCI
GQHYAQLNLVLLIGKASLLLDWKHHATPLSEEIKVFATIFPKDDCPLTFNKRKW*
>CYP61A8 P450-49 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
93% to P450-10_var1
53% to CYP61A3 S. pombe in CYP61 family
RO3G_16941.1
MSASSTSLFNPRSIESAKNAINSFVRSALNTQPSTTVLVCSALVGLFAYEQYVYLKKKRSLPGPLLKIPIIGAFMDSLYPTFEGYMSKWRSGELSCVSVFDRFVVIASTCELSRKILNAPAYAEPAVVNSMRHILCADNWVFLSGKAHVDYRKGLNVLFTRKALGIYIPIQEKVYQKHFDEWLSLDGRSEQYQLRFREINMEASLRVFLGEYMSDAVATQISQEYFNITAALELVNFPIPLPGTKVYKAIQSRKFIVKHFIECIKDSRIRMAQGGEVKSMMDAWISSMNEYEVECEKAGKPAPRKFDDREVALTILTFLFASQDATSSALTWAFQLLADHPDVLEKVYQEQLRLRKDNLQQELSLELMDASTYLRQVIKEILRLRPPVLMVPYQTVREWPITPNYTIPKKSMVIPTTYPALHDPVAYPNPDAFDPERWGPEGIAEKYPKNFMVFGNGPHHCLGKEYAMMHLMAVISQATLQMKWTHTRTEKSDDISIFATIYPQDGCIMSFKPRN
>CYP61A9 P450-8 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
50% to CYP61A3 S. pombe = CYP61 C-22 sterol
desaturase
RO3G_04483.1
MDSVFIEKARKLFEKTVEQIKEVIAEGLAADKAYFTPIGLASAAVAGFLVWEQVDYHRKKRHLPGPSFKMPLIGSLMDSMEPTFDKYNSKWKSGNLSCVSVFNRFIVIASNCELSRKILNSPGFVQPAVVDSMRYILTDDNWVFMDGKEHLNYRKGLHSLFQRSSLGGYLTIMDKCYQKFFDEWLSHEGKTRRYQWDFRELNMQSSLRVFLGDFMPESVAKKCSEEYFNITAALELVNFPYPLPGTKIYKAMKSRQYIYDAFVESIKDARIRMSQGSQTTCLLDNWLVTMKENERECLEAGKPAPHVFTNHEIALTILTFLFASQDATSSALTWTFQLLADHPETLKKVYDEQDKLRADDPNQPLTLELMEKSVYLRQVVKESLRLRPPVLMVPYQTHRDFPISDGYTVPANSMLIPTTYPALHDPVAYPNPDAFDPDRWGPEGVAERHPKNFMVFGNGPHHCIGKEYAILHVMSTVAQATRRLEFKHYPTSESDTIWLFATTYPKDECSMSFHPRTKFPYH*
>CYP61A10 Aspergillus terreus NIH2624
NW_001471411.1
AAJN01000002.1
72% TO 61A1 A.
ORYZAE, 55% TO A. TERREUS 61A6
70% to CYP61A1 A.
niger
formerly CYP61A1, but
a better match was found in A. terreus to CYP61A1
ATEG_00175.1
247642
MDFISKNTSPIIQKFQSPGIVAIFGSDISIWMVLLTVLITAVVYDQ (1) 247780
247843
FKYIRLKGTIAGPSWKIPFMGPFLESMDPKLEGYMAKWRSGELSCVSIFHK (2) 247997
248055
FVVIASTREMSCKIFNSPMFVKPCVVDSAHKLLGKDNWVFLDGKEHVDFRKGLNLLFTR 248228
248229 SALACYLPRQEEVFDMYFERFVARSAANNYKPLPWMPEFRKLMCTISCRTFVGHYISESA 248408
248409
LDKIAHDYYLITAALELVNFPIVLPFTKSWYGKRAADMVLREFSQCAAKSKLHIASGGEI 248588
248589
TCIMDAWVKAQLDSAAYRKNVAAGIPCEKPSHLLRDFTDYEIAQTVFTLLFASQDAN 248759
248760
SSAITWLFQIMADRPDVLDKLREENLRARNGDCNARLSMELFDKLPYTRAVVRETLRYRP 248939
248940
PVILVPYIAKKDFPITEKYTIAKGSMVLPSIWPATHDAEAYPNPDSFDPDRWITGTAEQH 249119
249120
PKNFLVFGTGPHYCLGQTYVQMNLMAIIGKASLALDWKHHITPDSEQIKVFATIFPQ (0) 249290
DDCLLTFRRQPGS*
>CYP62A1 Aspergillus nidulans AN7824.1 stcB Emericella nidulans U34740
not a complete match 53 clan
MISQICNEVIGLVPKKEEPGWLSVTGHPGAVYCEN
SISSGPEATGAD
VSQAIRIAYFTPLKHIPGPWYASLTGLRLSWSVFANNRIHYVHSLHQKYGPIV
RIGPQEIDVADPVAGREIHRMGSGFMKAPFYELLSPGPVDNIFNFRDPKL
HAARRKLYARGFTLQSLRNEWEPKVRDIIKLTVEKIKCDAVKGEAEIMGW
WTLMANEIVCQLTFGGGAGIVAKGVKEPFVLMLERRMGDLAHLLKHFAPP
GYYLGRALAWFIPPLQDIFYSQERMFAAGGDVVSRAREAKKAQAEPRNLF
NKALEAGNLTDTDIITDAGALLLAGSDPTAISLTFLLWCVLSRPEVQKQV
EAEVATLEGELTDEACERLPILNAVIDESLRLYGAAPGCMPRSPPSGGVT
IGGYFIPDDTIVATQNWSLQRNPSIWDDADTFDHTRWLSNSRITDQAKLA
FNPFGYGARQCLGIHLGRMEMRLAAAMFFRECVGARLGRSVTDESMHVVD
SFIAGVPRDRRCAITLT*
>CYP62A1 Aspergillus parasiticus aflatoxin pathway
gene cluster
GenEMBL AY371490
complement(join(62552..62810,62866..64025,64093..64200))
gene="aflV
MTNTAPRELIRAIEHVPLTWWFLAVGGAWIVSKIIKILQTAYFS
PLRKIPGPWYARLTSARLAWASFANNRIYYVQSLHDKYGSIVLIGPEEVDIADPVAAK
QIHRMGSGFVKAPFYKLLSPGPVDNIFNFRDAKLHSTRRKLYAKGFTLNSLRQQWEPT
IRNIVALTVERIRHDAQQGEAEILGWWTLMANETVCKLTFNGGHDTVRNGTKDPFVLM
LERRMGDLAHLLQHFAPPLYYLGRLLGRAVPRLHDVFFSQETMFEAGKHVVAIARSAR
DAEGDRNLFVKALAAGDLESKIGGLNDTEIITDAGALLLAGSDPTALSLTYLIWCVLN
RPKLQAELESEVAGLQGDITDAACADLPILNAVIYESLRLYGPAPGAMPRSPPPDGAT
LCGYYIPPSAVVVTQNWSLHGSPKVWKDPHTFDHTRWLPGSSLSEEAKISFNPFGQGA
RQCLGIHLGWMQLRLATALFFRRCPGAKLAPSTTPESMVMIDSFIAGMPKARRCAIQL
>CYP62A1 Aspergillus oryzae
GenEMBL
BAE71332.1, BAE59529.1, BAC20333.1
66% to CYP62A1
Aspergillus nidulans, ortholog
MTNTASRELIRAIEHVPLTWWFLAVGGAWIVSKIVKILQTAYFSPLRKVPGPWYARLTSARLAWASFANN
RIYYVQSLHEKYGPIVLIGPEEVDIADPVAAKQIHRMGSGFVKAPFYKLLSPGPVDNIFNFRDAKLHSTR
RKLYAKGFTLNSLRQQWEPTIRNIVALTVERIRHDAQQGEAEILGWWTLMANETVCKLTFNGGHDTVRNG
TKDPFVLMLERRMGDLAHLLQHFAPPLYYLGRLLGRAEPRLHDVFFSQETMFEAGKHVVAIARSARDAEG
DRNLFVKALAAGDLESKIGCLNDTEIITDAGALLLAGSDPTALSLTYLIWCVLNRPKLQADLESEVAGLQ
GDITDAACADLPTLNAVICESLRLYGPAPGSMPRSPPPDGATLCGYYIPPSAVVVTQNWSLHGNPKVWKD
PHTFDHTRWLPGSSLSEEAKMSFNPFGQGARQCLGIHLGWMQLRLATALFFRRCPGAKLAPSTTPESMVM
IDSFIAGMPKARRCAIQL
>CYP62A1 Aspergillus flavus
99% to CYP62A1 Aspergillus oryzae
AFL2G_07212
MTNTASRELIRAIEHVPLTWWFLAVGGAWIVSKIVKILQTAYFSPLRKVPGPWYARLTSARLAWASFANNRIYYVQSLHE
KYGPIVLIGPEEVDIADPVAAKQIHRMGSGFVKAPFYKLLSPGPVDNIFNFRDAKLHSTRRKLYAKGFTLNSLRQQWEPT
IRNIVALTVERIRHDAQQGEAEILGWWTLMANETVCKLTFNGGHDTVRNGTKDPFVLMLERRMGDLAHLLQHFAPPLYYL
GRLLGRAEPRLHDVFFSQETMFEAGKHVVAIARSARDAEGDRNLFVKALAAGDLESKIGCLNDTEIITDAGALLLAGSDP
TALSLTYLIWCVLNRPKLQAELESEVAGLQGDITDAACADLPILNAVICESLRLYGPAPGSMPRSPPPDGATLCGYYIPP
SAVVVTQNWSLHGNPKVWKDPHTFDHTRWLPGSSLSEEAKMSFNPFGQGARQCLGIHLGWMQLRLATALFFRRCPGAKLA
PSTTPESMVMIDSFIAGMPKARRCAIQL*
>CYP62A1
Aspergillus nomius
AY510454
complement(join(68188..68446,68501..69660,69727..69834))
gene CypX of aflatoxin biosynthesis
92% to CYP62A1 Aspergillus flavus
MINTPPRDLIRAIEQVPLTWWFLTVGGAWILSTIVK
ILQTAYFS
PLRKVPGPWYARLTSARLAWASFANNRIYYVQSLHDKYGPIVLIGPEEVDIADPGAAK
QIHRMGSGFVKAPFYKLLSPGPVDNIFNFRDAKLHSNRRKLYAKGFTLNSLRQEWEPT
IRNIVALTVEKIRHDAQQGEAEILGWWTLMANETVCKLTFNGGHDTVRNGTKDPFVLM
LERRMGDLAHLLQHFTPPLYYLGRLLARGVPRLHDVFFSQEMMFEAGKSVVAIARGAR
GGEGDRNLFVKALAAGDFESKIGGLNDTEIITDAGALLLAGSDPTALSLTFLIWCVLN
RPKLQAELESEVAGLPEDITDAACAELPIMNAVIHESLRLYGPAPGSMPRSPPPDGAT
LCGYYIPPSAVVVTQNWSLHGNPKVWKDPHSFDHTRWLPGTSLSEEAKMSFNPFGQGA
RQCLGIHLGWMQLRLATALFFRRCPGAKLAPSTTPETMVMIDSFIAGMPKARRCAIQL*
>CYP62A1 Aspergillus ochraceoroseus strain
SRRC 1432
AY092402.3
join(18386..18418,18503..19650,19718..19979)
gene StcB/AflV in aflatoxin/sterigmatocystin
biosynthesis
80% to CYP62A1 Aspergillus nidulans
N-terminal exon modified to be more like
Podospora anserina EST CU876063
MDFFTSLGSTQWLSILVYVGGLWLLVKVFQVSL (0)
TLRIAYFSPLSRIPGPWYARLTGLRLSWSVFAN
NRIHYVHKLHQDYGPIVRIGPQEVDVADPALGREMHRMGSGFTKAPFYALLSPAPVDN
IFNFRDAKLHAARRKLYAREFTLQSLRKEWEPTIREITKMTVQRIKHDALNGEAEIMG
WWTLMANEVVCRLTFGGGAGTVAKGVKEPFVLMLERRMGDLAHLLKHFAPPGYYLGRM
LAHVIPQLHDVFYSQEKMFAAGGGVVSRARAVKRDGDDSGPSNLFNKALEAGSLTDTD
IITDAGALLLAGSDPTAISLTFLLWCVLSRPQIQHEVEAEVAQLEGEITDAACEGLPI
LNAVINESLRLYGAAPGCMPRSPPPGGATLGGYFLPADTVVVTQNWSLQRDPNIWENA
HSFDHTRLPREIRMTEQAKIAFNPFGHGARQCLGIHLGRVEMRLATAIFFRECAGARL
SESVTEESMQVVDSFIAGVPRDRRCTIRLG*
>CYP62B1 Fusarium graminearum FG05806.1
AACM01000233 FGcontig1.233_scaffold3
MTLITTPGAPLLAGVFLFVIISYTLVTSLSSPLRRVPGPWYTHFTHFVLK
FHIVTGNRIHYVHSLHQRYGPIVRLTPWEVSVSDAEAVSAVHKIGAGFLK
SAWYDGITPGREPGIFAMRDPHQHSARRRLFARAFSNGSLLTNWEPEIRQ
KTSLAVQKIKQDALGAGADVFKWWTLMATDVIAHLSFGESFHMLEQGKQT
RYIDSIQLAMINSGIRTELSWIYPFLKFIPSQGLKTLLNADNVVYDHGTV
AVRNMQSAGDGLSRANLFSQMVAEADGQEKTTLTASSVQAEAGNLIIAGS
DTTAVTLTYLVWAVLKHPQLQARLEEEVGSLSDELTFDELKNAPLLNSII
EETLRLYGAAPGALPRVVPGKGATLVGQYLPGGTVVSTQAYTFHRDENIW
PDALRFDGYRFMDKSKMTASQKAALSPFGAGSRICIGMHLAYMELRLGAA
LFFRECRGVKIGVEMTDEMMEMENHFLIAPKTHKCIVKL*
>CYP62B2 Nectria
haematococca
fgenesh1_pg.scaffold_23000205
Necha1/scaffold_23:519115-520695
66% to CYP62B1 Fusarium graminearum
This gene model seems correct DRN 2/6/06
MGLVNIALVPFLAIGVIILTAAYRLFSAATSPLRNVPGPWYSHVTSIVLKWHILAGRRVHFVHSLHLRYG
PVVLVSPDEVAISDLDAFSQIHKIGSGFTKSDWYDKLRSGREPGIFFMRDPHQHAARRRLFARAFSNSSL
LTHWEPEIRQKTQLAVAKIKNDAQIGSADVLKWWTLMATDVIAHLSFGESFRMLELGK
(0)
QTPYIDAIQAALLCGVVRNELSWIFPIIRRLPFKGIRDIMSADDVVFEHGAKAVKNMSSASDGLSTANLF
SQMLAQAQGQEKTEIKDSTVRTEAGNLIVAGSDTTAVTLTYLVWAVLSQPQLQAALEAEVCGLSPDLTFD
ELTSAPLLNSVVEETLRLYGAAPGALPRVVPGKGLSVRGYFIPPGTVVSTQAYTLHRDSTVFPDAHR
(2)
FDGERFMDKSTLTVAQKTAMSPFGAGSRICIGLHLAWMELRLATALFFRECRGAK
LDPGMTDDMMEMDNRFLIAPKGHCCKIQL*
>CYP62B3 Fusarium oxysporum
76% to CYP62B1 Fusarium graminearum
FOXG_07404
MYIANYLSMPLLAGVFLIGIVLYALVNAFKSPLRGLPGPWYTHFTHLVLKWQILAGNRVHYIHSLHQHYGPVVRVSPGEVAVSDLEAF
SKIHKIGSGFLKSAWYDGITPNREPGIFVMRDPHQHAARRRLFARAFSVSSLLTNWESEIRQKTELAVNNIKRDAQGAGA
DVFKWWTLMATDVIAHLSFGESFRMLELGKQTPYIDAIQSALLMSGIRAELSWIYPLLQRLPFQGLKKLLNADNVVFDHG
AIAVQNMQSAGDGFSKANLFSQMLAESDSQDKTNLSLLSVQQEAGNLIVAGSDTTAVTLTYLIWAVLKQPQLQAELEREI
SELSDELSFDELKSAPLLNSVIEETLRLYGAAPGALPRVVPGKGLDVCGHYIPPGTVVSTQAFTLHRNENIFDDAQR
(2)
FNGYRFMDKSTLTGAQKTALSPFGAGSRICIGLHLAWMELRLGAALFFRECRSATLSPEMADEMME
MENRFLIAPKGHRCIVKL*
>CYP62B3 Fusarium verticillioides
90% to CYP62B3 Fusarium oxysporum = ortholog
FVEG_04329 revised
MYIANYLNIPLLAGAFLAGIVLYTLVNAFKSPLGGLPGPWYTHFTHLILKYHILS
GNRVHYIHSLHQRYGPVVRVSPGEVAVSDLEAFSKVHKIGSGFLK
SGWYDGITPNREPGIFVMRDPHQHAARRRLFARAFSVSSLLSNWESEIRQKT
ELAVNNIKRDAQSTGADVFKWWTLMATDVIAHLSFGESFRMLELGKQT
PYIDAIQSSLLMSALRAELSWIYPLLKRLPFQGLKKLLNADSIVFEHGSI
AVRNMQSAGDGLSKANLFSQMLAESDSQEKTSLSTSSVQAEASNLIVAGS
DTTAVTLTYLIWAVLKQPQLQAELEREISELSDELTFDELKSAPLLNSVIE
ETLRLYGAAPGALPRVVPGKGLDVCGHYIPPGTIVSTQAFTLHRNENIFEDAQR
(2)
FNGHRFMDKSTLTAAQKAAFSPFGAGSRICIGLHLAWMELRLGAALFFRECCGASLSPE
MTEAMMDMENRFLIAPKGHKCVVKL*
>CYP62B fragment BI188839 Fusarium sporotrichioides EST
88% to 62B1
PRVVPGKGATLAGHYLPAGTVVSTQAYTVHRDESIWPNALRFDGYRFMDKSRVTATQKSA
LSPFGAGSRV
CIGMHLAYMELRLGAALFFRECRGVKLGVEMTDEMMAMENHFLIAPKAHKCMVKL*
>CYP62C1 Aspergillus nidulans AN6414.1 49%
to 62B1 53 clan
MMERSWKYIAIACALWVVQ (0)
IYSAITSPLRAIPG
PFYTSLTRLPLKLSIIAGQRIYFIHSLHQRYGPIVRVSPTEVSIASLPEF
REIHRVGSPFLKSNWYEKFVMGQHSPGVFAISDPKQHGARRRLFARAMSN
TELRRVWEDVVRSKVRLAVDRIKGELEADGARCDVLKWWTFLATDVVGHL
MFGEDFDMLNIGVKNEYIHVLESTMKGSGINAELPLVGCIGRHLPFSVVR
SMFRANDYLTNYGKRAVTNARAKSDSSRNIFSGMLYEAEKCTDSDSGLSE
LDIITEAGNMIVAGSDTTAVTLTYLVWVVLSRPQLQREIESEVLALEEGY
DDAKLETLPVLNAVIKETLRLYGAAPGSLPRTVPRGGATLGGYFIPEGMT
VSTQSWTVHRDENLFPDPDSFNISRWLEENDAGFPAAQLAFSPFGAGGRI
CLGIHLAYMELRLAAAEFFRRCRGVRLSPDTTWKIMK
PMNYFLIAPTGNRCDIMRG*
>CYP62C2
Aspergillus flavus NRRL3357
GenEMBL
AAIH01000225.1
63% TO 62C1
1 AA diff to
Aspergillus oryzae CYP62C2
AFL2G_00193
MEWQIYLGIAFALWIVQ (0)
955 VLYTAFTSPLRRVPGPLYTVLTRLPLKLASLTGNRIYFVHELHRKYGPIVRIAPDDVDISS
1137
1138
LAEFREIHRAGSPFLKSKWYEKFVPSKRSGVFTMRDPKEHAARRKLFARPFSKSELRRT 1314
1315
WEPAVREKVQLAVSQIQRELKAVGKSDLLKWWTFLATDVSGQLMFGESFNMLQLGK (0)1482
1535
KNQYINVLESTMMGSGIGAELPLVAWLGRHIPLSSFQNMFRATDYLFQYGQRAVTNSRTT 1714
1715 SNASRNIFAGMVYESEKGDGIITDEEVVLEAGNLIVAGSDTTAITLTYLIWAVLSQP
1885
1886
KLQRELEEEVNSLSADFDDSALEELPLLNAVIMEALRLYGAAPGALPRETPEGGAKFCGY 2065
2066
FIPQGMTVTTQAYSIHRDGDIYPDPERFDVSRWLKTETSASELAKKAFSPFGAGGRICLG 2245
2246
IHLAWMELRLATAQFFRECAGVRLAPSATWENMRPVNYFLISPRGHQCEVECNY* 2410
>CYP62C2
Aspergillus oryzae RIB40
GENEMBL
AP007151.1
MEWQIYLGIAFALWIVQ (0)
476019 VLYTAFTSPLRRVPGPLYTVLTRLPLKLASLTGNRIYFVHELHRKYGPIVRIAPDEVDISS 476201
476202
LAEFREIHRAGSPFLKSKWYEKFVPSKRSGVFTMRDPKEHAARRKLFARPFSKSELRRTW 476381
476382
EPAVREKVQLAVSQIQRELKAVGKSDLLKWWTFLATDVSGQLMFGESFNMLQLGK (0) 476546
476599
KNQYINVLESTMMGSGIGAELPLVAWLGRHIPLSSFQNMFRATDYLFQYGQRAVTNSRTTS 476781
476782
NASRNIFAGMVYESEKGDGIITDEEVVLEAGNLIVAGSDTTAITLTYLIWAVLSQPKLQ 476958
476959
RELEEEVNSLSADFDDSALEELPLLNAVIMEALRLYGAAPGALPRETPEGGAKFCGYFIP 477138
477139
QGMTVTTQAYSIHRDGDIYPDPERFDVSRWLKTETSASELAKKAFSPFGAGGRIC 477303
477304
LGIHLAWMELRLATAQFFRECAGVRLAPSATWENMRPVNYFLISPRGHQCEVECNY* 477474
>CYP62C3 Aspergillus niger
estExt_fgenesh1_pg.C_150110|Aspni1
67% to CYP62C2
MERQVALCAATAVAIWVLQIAYKLLRSPLRHIPGPLYTRVTRLPLKFSIVTGRRIYFIHNLHQKYGPVVRIAPDEVSVSS
LPEFKEIHRVGSAFLKTPWYQKFAWDRNPGLFTMRDPKEHAARRKLFARVFSKSDLRRTWEPEVKDKVQLAVSQIRGELL
RDGISDILKWWTFLATDVSGHLMFGESFDMLQYGK
VSYQSDYPCMRGSANCQ
KNEYINVLESTMMGSGINVELPIVGLLG
RYVPLASCQAMFRPSDYLTEYGRRAVSNSRTNSNSTRNIFTGMLNESEKASSMLSEEDVVIEAGNLIVAGSDTTAVTLTY
LVWAVLSQPTLQHDLEEEVSALDPNYNEAALEELPLLNAVITETLRLYGAAPGSLPRSVPNGGATFCGYHVPQGATVSTQ
SYTIHRDEELYPDPETFDATRWLGGHGNGSDVAKQALSPFGYGTRVCLGVHLAWMELRLAATEFFRECRGVRLASDTTRE
SMKPENYFLIAPSGHR
YSSSSGRKRMSGEEGGWFYGDSGDPVIRFGMMDRTGDQCQMDLQNDWVDAEPKQGCPCFRAVGP
TAASAEATWNHEKKTITRSSPPTTRGLAGLLNSPPPDLNKPEQQVTYRGSGRTGGCCQACCKGAALVRHEANPTSTLSPN
VAPLRGVSLPVGI*
>CYP62D1 Nectria
haematococca
fgenesh1_pg.scaffold_70000012
Necha1/scaffold_70:35727-37407
MMGLPGYQAILSIIGAALLAGWL (0)
VIGRAYLTPLRAIPGPWHAPLTCLWLKKQTIAGRRAHYVHELHLKFG
SVVRIAPEEISFNDTGAFKEIHRISGNYVKSPWYQCFRKGTTTDLFSMTNPREHAQRRKLFAPLLSNSAL
MRNWFDTIVDKVDVTIEKMKRQQLQEGQVDIFKWWTFMTADVISHLAFGEPLGMLEQER
(0)
HMQKIEDSTKLGLVGAELPFVRSLLEWTPIRSVRDIVNADVEVQSLATDVMTKTLRDGIGTTNIFSKMVA
EKEREAQALSDYQLAYEAGGLIVAGSGTTAVSLTYLVWAVLSQPAVQARLESELEKLPAGFSDSDLEALP
YLAAVIEETLRLYGAAPGALPRVVPEGGAKLAGYFIPQGIIVSTQAYTYHRDPEAYPEPEN
(2)
FVPERFLNASGQFKAPKTGVYAPFGAGSRTCIGIHLARIELRHGACFFFRECKG
ARLAPQTTPLSMEMVNYFLISPRSEQCWVTLSN*
>CYP62E1 Phaeosphaeria nodorum SN15
AAGI01000353.1
46% TO 62C1, 46% TI 62B1, 42% TO 62D1, 39% TO 62A1
MAFVDVVTANKPLLVALI (0)
FVYVGLTCPTRHLPGPWYTRFTHYRLKRAVVTGQRIFYIDALHKQYGPIVRLSPTEV
956
GVADLDAFKEIHKIGTKYMKSEWYLRLANFPKAGVFTMLDPREHGARRKLLSRSFSRSY
1133
LVENWEPAVREKALLVVTKIKVDAMQSTADVYNWWMLLASDVSAHLAFGESFRMLETGH
(0) 1307
ANQFIRVLKKLTMGAGIMVEMPFLRLLRFVPINAVQEMFNANEFILTGAGRAVEMARSRT
1542
GESNIFAKVIEDCEKEGEGHIDDMDVRIEAMNIIIAGTDTTGVTLTYLTWAVLQQPQ
1713
LQSALEVETAGLRENFTESDLINLPLLNATIEETLRLYGAAPSSLPRVVPQGGTRFSGHY
1893
IPQGVTVDTQAYTFHRDPRIWSDPLTFDPQRWISSQEGYTAEALSPDAKTAFHPFGVGAR
2073
SCIGIHLARMELRYAVAFFFRECRGIRLAPSTTLESMEFENFFLIAPKAHRCDITFQQ*
>CYP62F1 Mycosphaerella fijiensis
40% to CYP62B2 Nectria haematococca
41% to CYP62B1 Fusarium graminearum
e_gw1.7.207.1 revised at N-term
MELFLLGAIAAFLGLLYKV (2)
RKIVIHARNALPHIPGPWYTRYTSLVFYINGFIPRVPVWVDNLHRQYGPVVRITPNMVAIADPDGVADIFRSSRGYLK
GPIYDSFLRSFFAERNPALHGQRRRLFARPLANSSLQASWAPEIRQRVALAVKRIKDDALATGEGDAYKWWNIMTNDVIT
RISFGESLNLLESDEHLPYIEAVKKTIRCVSLHRNFPRIMPLAKYLPIRRLQEILNARPKAEKYTVKAVQNFRARIDKDQ
DKTAGTARNIFTQIVVQADDQDAEAVLAITDEDVHEEALTLMLGGTDSTSSTLTYCTWAVLRHPEIREELEKEVAALSDE
LSSKELEQARLLNAVIHETMRLYGAVSIGLQRVVPASGAQIAGFDLAPGTLVWPQMYTTRYDPSIWPDPLKFDPSRFFDV
KLPSMAEGNLTATQKKVYVPFGGGTRMCLGINLAYLELRLGLALFFRECKGARLSKSMTAEEMVHDNFFVSSPKGRRCMI
TLG*
>CYP63A1 Phanerochaete
chrysosporium (white rot fungus) AF005475
Scaffold_293a 98% to CYP63A1 gene model
complete all boundaries checked
MGLTQAQRLVLGQLARLVAPALAVCVLLAAARRTQLVRAPVWADALIALIAIPLFHVGRA
HWRYARLARKAARLGAALPPRWEGKLPGSVDVLQLVDEAYRHGFLS
DYFYEKFGELGHTYNFYVLWDMDYCTEDAAVIK
AVLATDFNNWVK
GERFDSYMHSVLGTGVFNAD
GELWK
FHRSMTRPFFARERITDFETFNRHAEEAILKMKERLREGFAVDFA
DLISRFTLDAATEFLFGACVHSLAGALPYPHGAPAHLHTTRARIPADDFAAAFRAAQDAV
SHRARLVWLWPWFELARSRTDAPMRTVDRYLTPIIERALAMSRAAKQAPQGEKEEVADGE
TLLDHLARYTT
DPTILHDEILNIMIAGRDT
TAGTLTFVVYFLTQHPNVLQRLRQ
EILDVVGPSNLPTYDDIKQMKYLRAVLN
ETLRLYPPV
PWNMR
YAVKDGILPNSEPDGKPWFIPAGAS
VSYSVHCMHRRKDYWGPD
AEEFDPDRFLDERLHKYLTPNPFIFLPFNAGPRICLGQQFAYNEMSFFLVK
LLQTFEDISFERDAFEPNALPPAEWAKFPGRKGKEKFWPRAHLTLYSE
GGMWVKMREAQAMGPQVA*
>CYP63A2 Phanerochaete chrysosporium
AY835607
cytochrome P450 monooxygenase pc-2
Scaffold_301b
MLVSVDALALRTLVYELTYLLYPAVPTAAALLLLQRLGSVWLPT
WTIVLLSLCSVPVAHRILLWLKDWRAARKAASMGAILPPRLKGRWPGSIDLLRQLTKT
FETGFLSEMLWGYMHVLGQTFEVYILWDSNYVTSDANVIKTILATDFDNFVKGEKLDV
CVRPVLGTGVFNSDGEMWKFHRSMTRPFFTRERISHFDLFDRHADATMAKMKARLAEG
FAVDFQDLISRFTLDSATEFLFGQCVHSLASVLPYPHDAPAHLQTTGASRTEDFARAF
AEAQDAVSFRLRMGWLWPWFELFGSRTKAPMAVVDAFLDPILRDAVARADKIKRENGG
RVPEVKGEIEEDETLLDHLVNVVQTKILHDEVLNIMIAGRDTTGGTLTSAVYFLSQYP
EVLRRLREEILEKVGPTRRPTYDDIREMKYLRAFINETLRLYPAVPWNVRYPVKDTTI
PGPHPDKPYFIPANTPVSYSVHCMHRRTDYWGPDAEAFDPDRFLDARVQRYLTPNPFI
FLPFNAGPRICLGQQFAYNEMSFFVIRLLQHFDEVQLCEDALAPDCRVPDAWRGAPGR
KGVERFWPKAHLTLYAKGGLWVKMREASTSEAVV
>CYP63A3 Phanerochaete chrysosporium
cytochrome P450 monooxygenase pc-3
AY255625
69% to CYP63A1
MPSSIDFPDRLVLRVIAYELVFLFYPAVPAAAGLVLLRRLTDIW
LPTWAIVLLSVCSLPVVHGLSIWRNHWRAARKAARMGAVLPPRLKGRWPGSIDLLMRL
TDAFETGFMSDLLWEYMHTIGQTFEVYVLWDSNYVTSDANVVKAILATDFTSFVKGKK
FDVCMRSVLGTGVFNSDGDMWKFHRTMTRPFFTRERISHFDLFDRHADDAMAKMKARF
AEGYAVDFQDLISRFTLDSATEFLFGQCVHSLASVLPYPHNAPAHLQTTSASAAEDFA
RAFAEAQTVLNFRIRMGWLWPWFELFGSRTKAPMAVVDAFLDPILKAAVERADKIKHA
NGGKVPEAKEEIDEDETLLDHLVKYTNDPKILHDEVLNIMIAGRDTTAGTLTSAVYFL
SQYPEVLRRLREEILEKVGPTRRPTYDDIREMKYLRAFINETLRLYPAVPWNVRYPVK
DTTIPGPEPDKPYFIPANTPVSYSVHCMHRRTDYWGPDAEAFDPDRFLDARVQRYLTP
NPFIFLPFNAGPRICLGQQFAYNEMSFFVIRLLQHFDEVQLCEDALAPDCRVPDAWRG
APGRKGVERFWAKAHLTLYAKGGLWVKMREAPTSEAV
>CYP63A4
PC-4(pc.151.16.1) Phanerochaete chrysosporium
MALPPGLQYLLPQLPLLLAPPAAVLLAAHAARAFAGTAAPAWALALACVLSWPVALTALVQLRAHRVAREAAARGARLPPAVEARYPGGVDLMRRNNSEVEEHIPGYRLSEFGRQYGWTYNFRMLFQDRVRGRPRPRPPGRILATDFTSYEKGAVFSAQMKSLLGTGVFNADGDLWKFHRAMTRPFFSRDRISHFDVFDRHAEDALKLAKARLSEGVPIDWQDLVSRFTLDSATEFLFGQDVRSLSAPLPHPPTAPQAQHDTHDAEHPANRFAHAFLQAQLASARRSRYTAAWPLWEFWENKVEKHTRVMDEFIQPLLRDALARKAKGADAQAEEAVADGETLLEHLVKLTDDPQIIHDETLNILLAGRDTTAITLTMAGYMLAEHPDILQRLRKEILDTVGTRRPTYDDIRDMKYLRAFINEVLRMYPPVPFNVRFSTAPTVWPSPEGDFYVPAGTRCMYSVFVMHRRKDLWGPDADKFDPDRFLDERLGKYLTPNPFIFLPFNAGPRICLGQQFAYNETSFMLIRLLQRVSKIELHPEVSPQSVAPPGWAASSISDGKDKVVFKSHLTMYVQGGLWVTMQFENPEEH
>CYP63B1 PC-7(genscan.57.18.1)
(genewise.57.16.1) Phanerochaete chrysosporium
MPHPFSRYRLRVFGDFVRIVLAPSFVFWSAVQILKLRLGLLSPAAWLTFLFAASYARVQYRGFLQRQEARRRGGVLPPEVVGRWPGNIDILIKLGKASLTAYPGSFYLDLFEEYQSTTLNLKLLWSDLVRCLSFCRLSAVLKTLSQIITMDEEHIKHILTTGFNHFWRGRRQKERMYAPSGASRRHDTDSQGDVSQEWKKHRALARPFFARDRISDFDLFEKYAGATLGILGGLAGRGAAVDVQDLYARFTLDAAAEFLFGERLDTLHGALPVAGQAKLGSKGAATDDAFGAFVRAFEASQDIITTRQVRGYFWPVRELFQDKVAPHAAVIGAFLEPIVQRTLDRKAKMRAAGVSPTTEHDTFLDYLADHTEDPKVIRDQLLNILMAGRDTTACLLTYVTYVMAMYPDIMQKMRQEVLHVCGHDAPNFEKLKALRYVHAVLNETLRVFPPVPMNVREVRARGVVLPHADPTYAAAPAPLYVPGGTVVMYLPVLTQRNTALWGDDADVFDPDRWLDARLRRFTENPMMYTPFSGGPRICIGQNYARNEATYLLVRLLQQFDAVALAPEAQPAGSLPPPEWRHARGRAAEERIWPAYAITLYVKVRLSLQWLYC
>CYP63C1 PC-5(pc.101.32.1) Phanerochaete chrysosporium
MELHPRQYRLRFLLDVLRAIVWPQLVFNAALYLAGFHPGAFLRVVASVLAVPLLGTVRTAISQRRNKIQAGAALGAKEVPCVRGKWPGNLDIVLGFVRSLKEAYLMQFLDDLFREYDCKTLNMRLLWEDQIWTIDEAHVRYMLAGPGFEWFHKGYYWQERMESFLGNGIFNRWAQRAIARPWFVKDRISDLNIFDRHTTTTLALISEFVDRREAFDAQDLFARFTLDSASEFLFGRCLDTLHGTLPVAGRAKMGPKGTAIEDAFGSFARAFEDVQVQIARRTRIGKPWPLFELFTDKTAPSVAVIHDWLRPIVHEALAKKSAASAEKESGEDSTFLSHLANSTDDPQDIAYSVLNMLLAGRDTTASVLSFVVYFLALHPHVTEKLRAEILQAYGPDGRPSVEDMKDLKYVRAVLNETMRLFPPVPMNLRLSDAHPRIFPASGSAPKYYVAPRTVILYSIFLVQRRTDLWGADALEFRPERWLEPATARLLADHPFAFTPFHAGPRLCLGQNFAYNEMTFFIVRLLQRVSGFELAPDAQPEGSLPPARWKYGEGRQAVEKIWPASSVTTFIKVSLASMPCCGERWLKRRRQGGLWVRAVPA
>CYP63C2 PC-6(pc.101.28.1) Phanerochaete chrysosporium
QRAIARPWFAKDRISDLNIFDRHTSTTLALIADFADRREAFDAQDLFARFTLDSASEFLFGKCAETLHGTLPVAGRAKLGPKGSSVEDEFGSFAWAFEELFHDKTAKHRKVIQDWLQPIVREALHSKAAAARGEDTGEGTFLSHLTKTTDDPQDIAYSILNMLLAGRDTTAAALSFTVYLLALHPEVVEKLRAEVVQAYGSDGRPSVEDMKSLKYLRAVLNETMRLFPPVPLNIRTSDDTPRVFPASAGAPKYYVPPRTPVVYSSVIIQRRKDLWGADALDFRPERWLEPETARRLAENPFMFMPFHAGPRLCLGQNFAYNEMSFFVVRLLQRVAALELAPDAQPEGSLPPARWKNGEGRQAVEKIWPGSSVTTYIKVSSTRSRPCG
>CYP64A1
Aspergillus flavus U81806
99% to CYP64A1 Aspergillus oryzae
AFL2G_07214 revised
MIYSIIICAGALLGLWILEKLLAPKDTRPPLPPGPWRKPIIGNL
TDFPPKGTPEWLFWAKHQERYGPMSSLEVMGQTIIMINDAQLGIEIMHKKSALSQMIP
DAPFAHMAGWGMSLATERNRQAWKTIRANMKQEIGTRRAISTFHPKMEIGIRRFLLRT
LDNPDDLRFHIRKEANAFMMDVAYGYTIAPHGKDELYDLTQQSVRQFSHIFSPGEWSV
NFFPILRYVPSWFPGASFQIKAAEYKRTIERMTMVPYLWIKDQVARGCSRPSILLRLL
QKGHYESGSHQEQVLVWTNAEFVMGGSDTTVSAVSSFFVAMALYPEVQRKAREELDRV
VGPTTLATFEHRSQLPFIDALVKEVFRWHPASPLGAPHITQEDQIWDGYLLPKGALLL
PNIWTFTHDPSVYHDPMVFKPERFLEGKDSPPETDPMKFVFGFGRRICPGRFVTDEKL
FLIACHAVSCFFISPKDPGAPEPDWLPGVISQPGAFDLNVVPRSPAHEELIRSIETDH
PWKNADATDISRFMARNQMI
>CYP64A1
Aspergillus parasiticus AF017151
MIYSIIICAGALLGFLILQKLLAPKDTRPPLPPGPWRKPIIGNL
TDFPPKGTPEWLFWAKHHERYGPMSSLEVMGQTIIMINDAHLGIEIMHKKSALSQMIP
DAPFAHMAGWGMSLATERNKQAWKTIRANMKQEIGTRRAIATFHPKMEIGIRRFLLRT
LDNPDDLRFHIRKEANAFMMDVAYGYTIAPHGKDELYDLTQQSVRQFSHIFSPGEWSV
NFFPILRYVPSWFPGASFQIKAAEYKRTIERMTMVPYLWIKDQVARGCTRPSILLRLL
QKGHYESGSHQEQVLVWTNAEFVMGGSDTTVSAVSSFFVAMALYPEVQHQAREELDRV
VGPTTLATFEHRSQLPFIDALVKEVFRWHPASPLGAPHITQEDQIWDGYLLPKGALLL
PNIWTFTHDPSVYHDPMVFKPERFLERQSSPPETDPMKFVFGFGRRICPGRFVTDEKL
FLIACHAISCFLISPKDPGAPEPDWLPGVISQPGPFDLNVVPRSPAHEELIRSIETDH
PWKNADATDISQFMARNQMI
>CYP64A1 Aspergillus oryzae
GenEMBL
BAE71330.1, BAE59527.1
99% to CYP64A1
Aspergillus flavus
MIYSIIICAGALLGLWILEKLLAPKDTRPPLPPGPWRKPIIGNLTDFPPKGTPEWLFWAKHQERYGPMSS
LEVMGQTIIMINDAQLGIEIMHKKSALSQMIPDAPFAHMAGWGMSLATERNRQAWKTIRANMKQEIGTRR
AISTFHSKMEIGIRRFLLRTLDNPDDLRFHIRKEANAFMMDVAYGYTIAPHGKDELYDLTQQSVRQFSHI
FSPGEWSVNFFPILRYVPSWFPGASFQIKAAEYKWTIERMTMVPYLWIKDQVARGCSRPSILLRLLQKGH
YESGSHQEQVLVWTNAEFVMGGSDTTVSAVSSLFVAMALYPEVQRKAREELDRVVGPTTLATFEHRSQLP
FIDALVKEVFRWHPASPLGAPHITQEDQIWDGYLLPKGALLLPNIWTFTHDPSVYHDPMVFKPERFLEGK
DSPPETDPMKFVFGFGRRICPGRFVTDEKLFLIACHAVSCFFISPKDPGAPEPDWLPGVISQPGTFDLNV
VPRSPAHEELIRSIETDHPWKNADATDISRFMARNQMI
>CYP64A1
Aspergillus nomius
AY510454
join(63157..63352,63429..63558,63614..63805,63870..64021,
64071..64315,64373..64644,64705..65104)
gene OrdA of aflatoxin biosynthesis
93% to CYP64A1 Aspergillus flavus
MIIGLIICAGALLGLWLLEKLLAPKDTHPPLPPGPWRKPIIGNL
TDFPPKGTPEWLFWAKHQGRYGPISSLEVMGQTIIMINDAQLGIEIMHKKSALSQMIP
DAPFAHMAGWGMSLATERNKQAWKTIRANMKQEIGTRRAISTFHLKMEIGIRRFLLRT
LDSPDDLRFNIRKEANAFMMDVAYGYTIAPHGKDELYDLTQRSVRQFSHIFSPGEWSV
NFFPILRYVPSWFPGASFQVKAAEYKRTIEKMTMVPYLWIKDQVARDCCRPSVLLRLL
QKGHYESGSQEEQVLVWTNAEFVMGGSDTTVSAVSSFFVAMALYPEVQRKAREELDRV
VGPTTLATFEHRSQLPFIDALVKEAFRWHPASPLGAPHITQEDQIWDGYLLPKGALLL
PNIWAFTHDPSVYQDPMVFKPERFLEGNGSPPETDPMKFVFGFGRRICPGRFLTDEKL
FLLACHTLSCFLVSPKDPAAPEPDWLPGVISQPSPFGLNVVPRSPAHEALIRSIETDH
PWKNADATDISRFMARNEMI*
>CYP65A1
Fusarium sporotrichioides AF011355
MFQYSLWPLLALSGGTGLAYLVVVVVYNLFFHPLRNFPGPWLNS
ITQVPHTLLMLCGLPHKKHLALHMKYGPVVRIGPNMLSFNHPDAMKDVRGHRKSGEPE
HGKDPISVQSNGDNIVGSDRENHTRFRRALAYGFSAQAMLEQEPTFKAYVNQLFQRLH
EQSSGGTKPVDISKWYTFTTFDMIGDLAFGESFSCLDNSTYHPWVSLAFESLKSLAFL
AEIGRYPRIAPYLGLLVPRGLLTKFAENKELASMKVRKRLDTETDRPDFVGKITQGLK
SKGTSMEFNELASNASVLIVAGSETTATLLSAAVYFLCAHPRTLDLLTKEVRSTYTQA
HDIDLVSTQGLRYMQAVLDEALRMYPPVAGGGSPRKIAKGGSFVAGHFVPENTLVEND
MWAMHYDPKYFTQPHDFIPERWLGDVRFANDRLDAVKPFSIGPRNCIGMNLAYAEMRM
MLARTVWEFDIRLSEGSRNWYEESRVYLAWNKPPLNVYLIPR
>CYP65A2 Fusarium graminearum FG03540.1
AACM01000159 FGcontig1.159_scaffold2
MFQYSLWPLLALSGGTAVAYFLVMLVYNLFFHPLRNYPGPWLNTMTQIPH
TLLMLCGLPHKRHLALHMKYGPVVRIGPNMLSFNHPDAMKDVRGHRKSGE
AEHGKDPIIVLSNGDNIVGSDRENHTRFRRALAYGFSAQAMLEQEPTFKA
YVNQLFQRLHEQSSSGIKPVDISKWYTFTTFDMIGDLAFGESFGCLDNST
YHPWVALAFESLKSLAFMAEMGRYPRIAPYIGFLLPRGLLTKFAENKELA
SMKVRKRLDTETDRPDFVGKITQGLKAKGSRMEFNELASNASVLIVAGSE
TTATLLSAAVYFLCSNPRTLELLTQEVRSTYTQADAIDLVSTQGLRYMQA
VLDEALRMYPPVAGGGSPRKIAKGGSFVAGYFVPEDTLVENDMWAMHYDP
KYFTRPNDFIPERWLGDARFSSDRLDAVKPFSIGPRNCIGMNLAYAEMRM
MLARTVWEFDIRLAESSRDWYQDSRVYLAWNKPPLNVYLDPR*
>CYP65B1 N.
crassa AABX01000364.1 cont3.489
23181
MMMMMMNLSHLLPLGIPLPSPTSLIGIFLIG (0) 23273
23368
TSILVSSILLSAIYNLTLH
PLARHPGPFFHRASILPYLYRQITGTLPCSILDFHARYGPVVRI
SPNALSFADPQAWKDIYGHRPHGEEEFAKLNLFYRIKGSPPSLL
SETKEAHGTLRKLMAHGFSDRSMRAQEGIIGGYVSALIRGLRGNC (1) 23823
23968
QEQDERVPLDMVSWYNWTT
FDIIGDLAFGEPFGCLEKAEYDPWVDAVGKSVRFGCVMFALRLL
GLEDWVCPLVRKLSGNARRFHRKRTMDKLQRRVKLTKERPDFLE
GLLQKREEW (0)
24315
24423
GIDMDALAANASLLIVAGSETTATLLAGATYMLLRDPEAMKKLT
EEVRSTFKSEEEITLSSVGNLEYMLACLNEAMRLYPPVPIGMPR
VVPKGGAKVAGTFVPEG
(0) 24737
24819
TVVAVWHWATSHNEQHFVEPFEFHPERWMQDPRFANDRLDAVQP
FSVGPRNCIGRS
(2) 24983
25076
LAIAEMRLILTKVVYNFDMKLANPEKDWLDQHIYTLWDKHPLP
VYLTPIERNGV*
25240
>CYP65B2 Magnaporthe grisea MG06544.4 55% to 65B1 new N-term AACU01000188
cont2.1218
MIPPYIEPNVLGLVKLTAVL
(0) LPIYLLGHAVYNLFFHPLRRFPGPCLQHISYHAYAYR
LSRGTLAHDVAKWHRQYGPVVRISPDQLSFIEPDAWKDICGH
RTGSKANVDEMPKWPGFYTVNGRPRTIINETKENHAVLRRSLAHGFSDRS
MRLQEPIIGSYVDLLIRRLKERCHSEPAADRPGGLTTRQDIKTWYNWTTF
DVIGDLAFGEPFDCLEKAEYHPWVDNMNKTTKSFGAFMALKLVGFHWLVT
AILKYGLSKTREDHMRRTMAKIERRASLTVERPDLIEGLLQLKGLGKEQI
RITAGTLIIAGSETTATLLSGVTYLLLKNPEKLARLNEEVRSAFNDDNEI
TLMSVANLPYMLACLDEAARLYPPVAGGTPRVVPAGGASIAGTYVPENTV
VSVWQMAAYQNEQNFHEPFSFKPERFIERNSKVNTRDRFEVLQPFSVGPR
NCIGRNLAYAEMRLILAKILFNFDIELADKEKDWIDHKSYVLWDKPALDI
YLTPVRP*
>CYP65C1 N.
crassa AABX01000034.1 cont3.25
20288
MPVIDKLAGVTGLSGLHLLLGAVGVT (0) 20365
20487
ILLYIIGSAIYNVFFHPLASYPGPLLQRASPIPFSIRHALGVQP
FHTQALHDKYGPVVRIAPNHLSFTDVRAWRDIFGHIAGSRHGQE
ELAKFKSFVRPIDAQPIHIISAGREKHGQLRRALANSFSDASMR
GQGPLIGKYIDLLLHKLHEQGQEGKVPLNATSWYNSVTFDVAGD
LIFGMSFGALDQNGNHSWLQYILGSLSSLAPMAALSYAGLHWLV
QLLWRAKGAEVFRKSMESVDLMLKERLKMPVDRNDLFEGLVQRQ
EKL (0) 21287
21563
GLSFEELASNAWLLVL (2) 21610
21675
AGADTTATTLSGTTYLLTQHPEVLKRVTQEVRSSFKSVEEIDIS
SVNRLTYMLAVLNEAMRLYPPVTSLTARIVPRGGAHVLGEYLPEG (0) 21941
22014
TIVDIQQWSMNHSKENWVDPWAFNPARFLDDKETAREKGNVLDAL
QTFSVGPRNCIGRN
(2) 22190
22266
LAYAEMRWILARILFDFDLRGAPTNQNWIERQKAYGLWDRIPLD
VYFEPARERK*
22430
>CYP65D1 Magnaporthe grisea MG03832.4 47% to 65B1 partial seq. length 53916
runs off end, changed C-term AACU01001030.1
cont2.747
N-term on AACU01001031.1 cont2.748
seems to be missing some N-terminal seq.
MFSVLLQLLNDPLAGIPGPIYCRFSRLPYVYWVCTGRLVFRIKELHDQYGEVFRIAPDEV 289
288 QFINPEAWKDIFGHKTQGAKEFPKDLRFYPMPPGGVRDLLTADQANHPRMRKMLSPAFAE
109
108 KTLREQEAIITSYVDFMVGKLRGMVTKQED 19
sequence gap here
53789 RPDFMSYIMKGAETGQPLS
KEELDANADLLVFAGSETTSTFLSGCTYFVLSNPRVYRRLVAEVRGSFNS
EEEMTFASIQRLPYLSAVMQEAFRMYPPIPVGPPRKVPEGGAVVRGISLPEN
() 53427
53301
TAVAITQYAAGHSETNFTDPYTYTPERWLPDADERFASDRRRAVQPFA
VGPRNCIGQN () 53128
53026
LATAEIRLTMIKMLWHFEAELAPECENWHKQSIFGLWEKPPLMIKLRPRER* 52871
>CYP65E1 Magnaporthe grisea MG03830.4 37% to 60A3 AACU01001030 cont2.747
MAAPMSAFTIGNLFMLLVVALGI (0)
ISIYYGLLCIYNLYFHPLAKYPGPRLA
AATHLWLMRAYLSGKAHRHIHEAHKRYGPVVRTTPDGLSYVDARQWKEIY
GHQPSGRPEFSKQAFASAVFEEPTLHNADREYHGYVRRLFAHGFSEKALK
GQESVLKEYVDWMFAGIERESRGGSRPVNVVNWYNYLTFDFIGFLTYGES
FDCLRTSSLHDWIKLFISFGKLLIYGQVLLPIPRLLKIPAALLLIPSKLR
EDRKRASALQSEKIKHRLSIQPTITDFTTKMVEAYNNGKMSMNQLEGNSI
LLIGAGSETTATALSGLTWLLAQNPAVLAKLAAEVRSAFASTEQITSTGV
NSCKYLLACVEEALRVYPPLAQPHYRIVPRGGASVGGDHLPAGVVVSVPK
YAAARSPLNFHRPDDFCPERWLGGHDGEFAGDQRDASQPFSVGPRACIAR
NLAYLEVRLVIARLVWQYDIENATEGDWLGGQNLWHLWEKGPLWLRLKAV
R*
>CYP65F1 Magnaporthe grisea MG08498.4 42% to 65A1 AACU01001266 cont2.1600
MGLMQQTPAASFGLGTSTLLFSLVGFGIVSYVVYLAVVRPIYNVFFHPLS
KYPGPKSWAASRIPYVLSSTGGHLQYKLLELHCKYGDVVRIAPNELSYVR
PDAWKQVMGHRKHGESENGKERVNYTSFADSIIGADRHEHAQGRRVLSHA
FSAKRMLEQEPLIKKYIDLFFERLPVISEGCSKPVDIVRWYNYTTFDIIG
DLTFGESFHCLESKTMHPWVRLIFASVRDGNLLSNMRAYYSNIDSFMYRF
FPSAVKHKMQHEEMLRQKLKQREAMGSSRPDFYDSMTRRDKNGFGFTPIQ
IERNSDLLVGAGSETTATVLSFSTYLLCKHPEIQAKAAKEVRELFKSEDE
ITMTQVQQSHYLLAVLNEAMRLWPAAPAELPRQTPPEGSMVCGEFIPGDT
ILLVAQYPSNHYPGNWVKPEEFIPERWLKDADPIYDADKKEAFNPFNHGG
RDCIGKNLAYSEMRMILARMLYNYDMELDEQSKNWAEGMLAYTLWDKPPM
FVHLKPRKTEA*
>CYP65G1 Magnaporthe grisea MG00023.4 39%
to CYP65A1 41% to 65B1 AACU01001352 cont2.7
MSRLDLIHDLRSFAFGQPFWHYVWFALFLTTCYYLATTVYCVYFHPLAKY
PGPRLYAASQIPYAVVFAFGDGHNTIARLHREYGKVVRIAPDRLSFSSPD
SWNEIMGHQKKDRNREHGKTPNFYDPLSIPGTDREAHARQRRILAVGFSA
SYIVEQESIIHYYVGLLMNRLKENGQDGTKPLNMVNWFNWTTFDIVGDLA
FGESFGCLETGVYHPWVSLMFTHVKLGAWNYAIAQFPTFSKIIRSFVPKS
MTKKVEEHHAYTRDLVDRRLETDSSRLDLFRAMAHPRDGLSMSKEEIYSN
TGTLVEAGSETTSTALSGVLFHLLKSPEAMKKVKDEIRGTFKSEDEITYV
SVQNLEYLSACVREGLRIYPPIPSTVPRITPKDGSIIFGEWVPPDTKLDI
WQFPLSRNEKFFKDADKYVPERWLGDPRYQSDCREASQPFSVGPRDCLGK
NIANGEMRIILSRLLWNFDVRLADDSVDWDQGQKVYIIWLKSPLNVYLTP
VKRS*
>CYP65H1 Magnaporthe grisea MG10954.4 39% to 65B1 40% to 65A1 41% to
MG05390.4
AACU01001824.1 cont2.2124
MLEKYALRAIRPSHLFTYS (0)
AVAFLLGKCIYNLFFHPLRHYPGPFLCRASRVFYLFWD
VRGLSHWKVKQWHDQYGEVVRISPDELSMTNPEVWSTAYGFGAGGFDKDP
KWWNKNVGGVDNILTADDQGHRRMRRLQNPAFSDKALRSQEPRMTRYIDM
LIQQLRRQSSQGPTVDINLWYNFATFDLIGDLAFGEPFHCLRDGRWHWWL
TAVFEIFKAGTYIRAARRFPTALYYAILLCIVPKKLLQMRERQYMFGVER
INRRLEQTDTDKTDFMSYILQADDEKGMTVEEMYTSAQVLIVAGSETTAT
ALTSGTYFVLSNPDVYARLRAELDAAFASEADITLQSTQRSHLPYLHAVI
DETLRMFPPGPGAFPRVVPDGGRTILGRFIPGGMTVGMHHLSVGRSRENY
VLPNEFHPERWLAEDKRFDLDRKAASQAFSFGPRNCIGKNLALAELRLIL
ARMFWNFDMELCPESKGWTDRQQMYTTWKKTEMPIKISPRVR*
>CYP65J1 Magnaporthe grisea MG10070.4 39% to 65B1 , 40% to 60A2 AACU01001328
cont2.1928
MSATFKLDPASLDSLLINLPPLNWENGLRGISIALLVYFFILKPFYNVYL
HPLSSYPGPKLWAISRIPWHYTNLKGRISWRIREMHDTYGPVVRIAPDEL
SYTSSTAWRKIYAQRTPEFMKALDGRGIAPTSIGGRRSLMTETQDNHLRL
RKAINPAFSERALREQEHYLQSHSDNFVKVLTERSARGPVDMTTWYNLLA
FDIVSDLAFGEPAGFLDNADQPWIQVILHRAKAISWYQLAVWYGFFPLLE
YITPRYVTEARKNHIRLTEAKLERRMAATNPGRDFMSFILDNDNEAVTKL
SKVELVMLSSNFIVAGSGTSAGGMSGLTYLLLRNPDKLERLRREIRSTFA
RNQDITMVATAKCRYLNACLDEGMRLYPPTPGSLPRIVPGDGQEIDGRWV
KGGMGVAVNQLSAGHSELNFKRAREFHPERWLHLEPGSEFANDDRAASQP
FSAGQRVCIGRSMAYAEMRLTMAKFIFHFDMELANPEMDWWNQQGTYLVW
EKIPLMIQLHRRT*
>CYP65J2 Alternaria solani
Alt3 BAD83682 69% to 65J1 Mg
PKS for alternapyrone is next to three P450s
called alt1, 2, 3
Chem Biol. 2005 Dec;12(12):1301-9.
1 malssaldsl whqldqllsl inrniitgii vlpvlyvllk
viynlylspl agypgpklwa
61 vsrlpwnran mkgriswkir
elhdkygpvv riapdelsyt tsgawkkiyg qrnpefvkal
121 dgrgiapasi ggqrslmteh qdkhlrlrra
idpafsqral reqesyfqdh sdnlvqklkq
181 rckdgpldmt twynlvafdi vsdlafgeps
gcvnnpdqpw iqailaraka ivwfqlavqy
241 gfmgllnwmt pkyvtesrkk hiamteaklk
arveaknpgk dfmsyilend eklnhlelvm
301 lssnfivags gtsaggmsgl tylllrnpdk
leklkqeirg lfksradmtl qavtsckylr
361 aclnegmrly pptpgslprf vpgkgemieg
kwvpggyavg vnqlaaghse rnfkkarefh
421 perwldepds efkdddrsav qpfsygqrgc
igrsmayaem sltmaklvwy fdweldepdn
481 dwwnqqgtyl vweklplqvk ltpvsdvve
>CYP65K1 Magnaporthe grisea MG09945.4 poor match 41% to MG02982.4
AACU01001747.1 cont2.1897
MDYISNA (0)
AVYDLTIHPLARFPGPRLSALSRLPFCIARMRGDQVQWMHSMH
LKYGPVVRFGPDELSYVDQGGSAWKAIYGQEKGAKEFPRLKAWFRAAFSP
AFSERALRSQEPLFRRQIDLLISILASDAAETGGPANLTELFEFTTFDIM
GDLALGEPLGMLQTQQYSKWMKALASGVRIMPVFQFIQHYPLVSKIFSLL
EPEWVTQLKYEHHQYNVDRVNARLARESSSQADIWSYVLSTKEKQRLTVE
EMHSNAESFMIAGSETTATAMTALTYFLTTSPSRFSRLKNEIRSRFSSEE
DITMETTSPLKYLNACIQEALRMYPPLPVGVPREVTSPGATILGRWVPGG
TQVSVHHYASSHSPGNFTDPDTFAPERWLAREPADGDNGTNATDSARYGS
DRLEATQPFTVGPRNCLGKSMAMHEMRLMLACLYFRFDMELVSDAGAVPW
NQQKAFAFWDKKPLMCKIKLANGGI*
>CYP65L1 Magnaporthe grisea MG02982.4 42% to CYP65B1 38% to 65A1 AACU01001589
cont2.600
MASNGAGVFYSSAFFQIRDLGAAEIVRRIALFSAYSFSLFLVFFTIRAIY
NIWFHPLSKYPGPWYAATT
NLVYYIADITGYRERWILRQHQKYGEVVRTG
PIRLSYTSASAWKDIVGHRSAGKLEMLKDPWLYDAGQAFGSDGVSMISNV
DSETHGKMRKIFTSAFSDRALREQEPLLLKYVDKLIRRIHTDLSGDPNRP
LDLVLLLNCTTF
DIMADLTFGESLGMLDNGKYTPWVARIFDTIRYAAIFG
IAGRWVWLRNLVRATLPASMRKSLEEHRGYVNER
VERRMDKDTDQPDIWN
LVLRNPENVKLLGRGSMNEHANLFMVAGTETTATLLSGLTYFLLKKPSTY
EKIVAEVRSLPEDGLHIDSLRQLPYLQACFEEALRMYPPVPMGMPRVVPP
GGAAISGGFVPEGTRVAVHQLSCYRNEKNFKNAFEFIPERWLPEYADEYG
SDRKEALQPFSYGPRNCMGKNLAYHEMRLIFAKLLWNFDIELCPESDNWT
DQRIFILWEKHPLMVKFKPRKV*
>CYP65M1 Magnaporthe grisea MG00651.4 37% to 65B1 AACU01001445 cont2.120
MVALVRGSVVNLGFW
GWILITGVMLLAIPTYIFIYNIWFHPLAAFPGPLMYRAFDSFKVYQQLTG
NINHRLHAAHEKYGDVVRIAPWQLSYTTATAWTDITAGHKGQIPTNPAYG
QAEKDLFGASGFLWVGNDEHARHRRVLSPAFSDRSLREQEPVVSKYLDLL
VARMKERSGDVVDFWLWMNFTTFDIIGDLTFGESFDCLLESRLHPWVDYL
MSRLHMMMYGQIMSTMGNLGVLVEMMVPKRIMDEAKRHVSLAKDKVNRRI
ARTTDRPDFMTQILAHTTIDTEAAGESKHKNRLSLPELYADTQIMVIAGS
ETSAGLITAAAYFLLRNPKAMGRLVREIRGTFAQETDMGNAAVSKLPYLN
AVVNESLRMRPPLPSGIDRKVGAGGAVVDGKFLAPGTSLQVTHWAAYHSA
RNFAEPWSFRPERWLSEREAEEDVSVFAGDNKAVFQPFGVGSRGCLGRGL
AYMETRLTLARLVWNFDMELMADSADWADQRVWMLYEKKPLNLRLVPRGM
AESYELSAQTRDRLWHTAGESKVDVRG*
>CYP65N1X # name changed to 563B1
no sequence
>CYP65P1 Magnaporthe grisea MG07983.4 48% to 65B1 partial RUNS OFF END
AACU01000985 cont2.1482 C-TERM HALF
MSEGEIISNSALLIIAGSETSASYLAGVTYHLCTYPYVMKKLTSLIRSSF
ATEAEITSSSLAQLEYLTAVLKEAGRTYPALPSGQPRLVTETGAFISGEM
VPPGTLVFSHPMGASMAPFNFTNPEQFVPERWLKDPPFPYNDDNLDASMP
FGLGPRSCIGQSLAWIEMRLILGRLLWNFDLSLSPECSRWIKEQKVFQVW
EKTPLKVKITMRHDLERK*
>CYP65Q1 Fusarium graminearum FG07765.1
AACM01000318 FGcontig1.318_scaffold4
MSVLSILLDGEVIHPMVLLPLAAVTMLVGYVLFWVIYNLSFHPLSKFPGP
RLWAISTIPYIRNFTAGECHFTILEMHKKYGPIVRVGPNDLSLNHPDGMK
ALRGHRKSGTGENSKEPVAASFNADNVIGANRENHQRYRRTLAHGFSQHS
MMAQQPIIRVYVDKLMKGLHAASDNGTKPVDIATWYNFTTFDVIGDLAFG
EPFGCLDTGKLHPWITLIFAGMKDLAFITTMARTPWLNNLWNLVTPKKST
SEWASHVEMAREKVRKRLASGMDRPDFIDAMLKRTGAAGNEMTFEELASN
AQILMIAGSETTATVLTATTYFLASNPETLKKVVNEVRSGFSSENDINMD
SVKKLTYMLACLNEGMRVFPPVINGSVRTIRPEGDDIIGHYIPGGATVDV
WQWAVHNNPDHFAHADQYIPERWLDNNDPRFANDAKQALNPFSIGPRDCV
GKNLAYAEMRMILARVLWNFDVSLHPDTPGWEKRTKSYFLWERGAMNVML
TPRKTE*
>CYP65R1 Fusarium graminearum FG03191.1
AACM01000148 FGcontig1.148_scaffold2
MFSALTALAGSLVLYIICTSIYYITFHPLASIPGPKICGITRIPYWLVAF
RGEDVRWMKTLHDKYGPVVRFGPTDVSYAATQAWNDIHGPKDSEKAQEFS
VQPVNGVPSMLTTDVENHTRMRRLFSPAFSERALKKQEPLFKKYSELLMY
KISEVGDNGAKPVEMCQLLNFTTFDVMAELCFGDHLDLLAKNEYSPWVRS
IFESLKMLPIASMINYYPILNALFTRFEPK
SVTQQRVTHCKHSEERVNRR
LENGSDQPDVWNLVLEAKEGKGITVK EMHSNAELFMLAGSETTATLLSGC
LYYLLSCPDKMDILLKEIRSKFDKVDDITFERLAELKYMNVCIKEALRIY
PPVPIGSPRVVSPGGQQILGKYIPAETRVSVHHWSTYRSESNFKDADKFV
PERWLKTEARYAGDALEAHQPFGFGPRNCLGQNMAMHEMRLILTTLVFSF
DFELCEESKNWADQKSFALWIKNPLMIRATPVTTHARLNI*
>CYP65R2 Fusarium oxysporum
82% to CYP65R1
frameshift at
TLQ/KMH = &
FOXG_10066
MGPILASIAILALYLLGNAIYHATLHPLANIPGPKICGITRIPYWLASLKGEDVKWMKGLHDRYGPVVRFGPTDVSYTAS
EAWNDIHGPKVTEKAQEFSVQPVNGVPSMLTTNTENHTRVRRLFSPAFSERALKQQAPLFKKYSELLMYKISEVGNDGAK
PVEMTQLLNFTTFDVMAELCFGHPLNLLVHNEYSPWVRSIFESLKMLPIASMINYYPILNAIFTRFEPKSVTQQRVTHCKHSEDRVNHRLENGSDQPDVWNLVMSAKEGKGLTLQ
&
KMHSNAELFML
AGSETTATLLSGCLYNLLTYPEKMKTLLEEIRGKFTNTDDLTFERLAELKYMNACLKEALRVYPPVPIGSPRVVQPGGQQ
ILGKYIPPETRVSVHHYSTYHSESNFRDADTFVPERWLKTDSKYAGDMWEAHQPFGFGPRNCLGQNMAMHEMRLILATLL
FKYDLELCEESRNWVDQKSFALWIKTPLMMRAKPVATHTRLNI*
>CYP65R2 Fusarium verticillioides
95% to CYP65R2 Fusarium
oxysporum = ortholog
FVEG_08438
MGPILVFIAILGLYLVGNAIYYVTLHPLANIPGPKICGITRIPYWL
ASLKGEDVKWMKGLHDRYGPVVRFGPTDVSYTAGEAWNDIHGPKVTEKAQEFSV
QPVNGVPSMLTTDTESHTRVRRLFSPAFSERALKQQEPLFKKYSDLLM
YKISEVGNDGAKPVEMTQLLNFTTFDVMAELCFGHPLNLLAQNEYSPWVRSI
FESLKMLPIASMINYYPILNAIFTRFEPKSVTQQRVTHCKHSEDRVNHRL
ENGSDQPDVWNLVMSAKEGKGLTLEEMHSNAELFMLAGSETTATLLSGCL
YNLLTYPEKMKTLLQEIRGKFTSTDDLTFERLAELKYMNACLKEALRVYPPV
PIGSPRVVQPGGQQILGKYIPPETRVSVHHYSTYHSESNFKDAESFVP
ERWLKTDSKYAGDMWEAHQPFGFGPRNCLGQNMAMHEMRLILATLLFKFDLE
LCEESRNWADQKSFALWIKTPLMMRAKPVATHTRLNI*
>CYP65S1 Fusarium graminearum FG08023.1
AACM01000323 FGcontig1.323_scaffold5
possible deletion at the I-helix
MAIISTDLASGTSLGGGLVLLAAAVVLFVTGRAIYYVFFHPLAKIPGPKL
YAATQLPYLYHLTRGQWVYRLKELHEQYGPVVRYTYNDVSFITADAYKTI
YGHKTGGAREFGKDFRLYRQGRPAPSLIVTKHEDHKRQRKLLSHAFSHKA
LSEQNDLLMHYVNLFIEKLTQKAREGESVDMVAWYNFATFDLIGHLALGQ
PFGCLESGKYHPWVTKIFSSIKGISFSQAAIRLGLHNWISLITPAHVKKA
TKEHFEFTEHVAGARLDVKDNNSKDFMSYILRYNDER
XXXXXXXXXXXXXXXXAGSETTATLLSGV
TYQLLTNPEAYKKLVTEIRLAFATEEDITAAAVDKQTYLLAVLSEGFRMY
PPVPGALGRTIPKGGDFVEGHWFPENVGVSVPQLPAYHSARNFKDPEKFV
PERWMDDPRYSNDCRAVVQPFSMGPRDCIGKNLAYLEMRLLLTRLLWKFD
AELMPESREWKEQKIFTLWEKGSLHVKLTEVVREKN*
>CYP65S2 Nectria haematococca
e_gw1.7.949.1 short on N-term
Necha1/scaffold_7:62397-63948
54% to 65S1 F. gram. yellow indicates 65S1 is
short there, needs correction
MAVLSVFSSQLASFTAVAVALSLT(0)
VVLYLSLRGAYYAFFHPLAKVPGPKLYAASSLPYYLHLLRGDWHQSLKEMHDRYGPVVRFAPADISFITATALKQIYGHK
SSLDATFVKDPPFYHRGMKDPTIINANHEDHKRFRRLLSHAFSEKALRSQEDILKLYIDKFINRLAQKAH
DGVAVDLVSWYNFATFDLIGDLSFGEPFGCLDSGGYHPWVRLVFQHVKAIPYRQIAQYLNMGFLVPYLTP
KRLVKASKQHLQLSRETAMKRVATTTDRADFISYILRHNDEKG MSDGEIAANSHILILAGSETTATLLSG
VTFQLLKNKAKLDKLISEIRSSFDAEDEITLERVNQLSYLLAVLNEGLRI
(1)
YPPVPTGLPRLVPSGGEIMERFWIPEKA (1)
ISVPHWAAFHSE
SNFRDADNFVPERWLGDISYTNDSKDVLQPFSTGPRNCIGKN (2)
LAYAEMRLILARLLWKFDLEILEDSKDWDSQKSFLLWEKGALLVRLTEVIRD*
>CYP65S3 Nectria haematococca
fgenesh1_pg.scaffold_4000060
Necha1/scaffold_4:143263-145075
60% to e_gw1.7.949.1, 56% to 65S1 Fusarium
graminearum
MPALSHYFERMDNVPPLGIAILAASLA (0)
VLYFFASGIYYAFFHPLAKVPGPRLYSFTQLPFFYYWIQGNWERRLKELHDKYGPVVRFTHKDVSFITAD
AMKKIYGHKTSMAQTFEKDALFYKPVRDQTDIINANTEDHRRFRRLLAHAFSDRALRGQEEIMQHYVDKF
ILRLTELAHQDTGIDVVRWFNFTTFDIIGDLAFGQSFGCLDSGGYHPWVAMIFSSVKTGPLRAAMQRLGL
GKFVSLLMPAHLKRSLEEHFQLSKSTAMKRIESRDTEREDFMSYILRHNDEKG
MTRSEIAENAKILIIAG
SETTATLLSGVTFQLLTNRDKYEKLVKEIRTSFTNEQEITIARVNQLHYLIAAFSEGSRM
(1)
YPPVPIGLPRETPKGGEEIEGYQIPED (0)
VTVSVSHWSAYQSEINFRDPKMFIPERWLGDPRYDGDAKEVLQPFSIGPRNCLGKN
(2)
LAYAEMRLILAHLLWKFDLELVSESKNWNDQKVFNLWEKGDLKVKLTPVGEIGRD*
>CYP65S4 Fusarium oxysporum
58% to CYP65S1 Fusarium graminearum
FOXG_02668
MGVLHTEALAELSLGSAMALSGIALLLYLFISSVYYAFFHPLAKVPGPKLYAITQIPYLYYLSKGDWVFHLAKLHEQYGP
AVRFTPKDVSFITAEASKKIYGHKAAGNKSFEKDFRMYRQNRPCSSIVRSDQEDHRRMRRLLAHAFSSKALRGQGDVVDH
YVELFMKGLTERAQRGEEIDIVAWYNFASFDLIGHLALGQPFGCLENGKYHPWVSRVFKGLKVLSYTQIYVRLGLQNWIS
LLSPPSLRKSYEEHMQFAEHAALARIESKDTDSQDFMSYVLRHNDEKGMSQLEIIENSGVMIIAGSETTATLLSGTTYFL
LKNPDKLEKLINEIRSAFSSEEEITVTQVDQLKYMLAVFNEGFRMYPPVAVGLSRLSPAGGEFIDGYWIPENTAVSMPHW
PAYYSELNFRDPKKFVPERWLDDPRYASDNRAILSPFSLGPRDCIGKNLAYTEMRLLLARMLWKFDLEAVPADKDWYDQK
IFFLWEKGGLPIKLKEVVLKAARFSDLQRATKSNCNASEYHEWAILGSVAKSSSPACIPRTQQWDAHKATAHKPDASSSI
EKSICKTGVNSLVMNFCFTFEFLSNASPRCTITTSEESKDDSEYESKSRASVYR*
>CYP65S4 Fusarium verticillioides
94% to CYP65S4 Fusarium oxysporum
FVEG_14141
MGVLYTEALAELSFGSVFALLGISLFLYLVVSSTYHAFFHPLAKVPGPK
LHAITQVPYLYYLSKGDWVFHLAKLHERYGPAVRFTPKDVSFITAEASKKI
YGHKAAGQKSFEKDFRMYRQNRPCSSIVRSDQEDHRRMRRLLAHAFSSKAL
RGQGDVVDHYVELFMKGLTERAQRGEEIDIVAWYNFASFDLIAHLALGQ
PFGCLENGKYHPWVSRVFKGLKVLSYTQIYVRLGLQNWISWLSPPSLRKS
YEEHMQFAEHAALARIESNDTESQDFMSYVLRHNDEKGMSQLEIIENSGV
MIIAGSETTATLLSGTTYFLLKNPDKLEKLTNEIRSAFSSEEEITVTQVDQ
LKYMLAVFNEGFRMYPPVAIGLSRLSPTGGEFIDGYWIPENTAVSMPHW
PAYYSELNFRDPKKFVPERWLDDPRYASDNRAILSPFSLGPRDCIGKNLAY
TEMRLLLARMLWKFDLEAVPTEKNWYDQKIFFLWEKGALPIKLKEVVREKV*
>CYP65T1 Aspergillus nidulans AN7522.1 38%
to 65A1 53 clan
MPLTLSLILWPLVGFCLYVAIITTWYTLFSPLRVIPGPKSWTFFPILRHI
SAILGRFDTDMRRFHAQYGPVVRFGPREVSFITADAWKTIYGHGHTQLPK
YMHSAADPQSIISTNDTDHSRYRRALSHAFSARGLQEQEPLIQSYVDKLI
VRLKGVAESGRPEDMVKWFNLTTFDIIGDLAFGEPFGGLDSAEYHHWVST
IFQSIKVNPFILLKDNYPMLGWLLLRAFVPETLRQAKKRQIEHSRVTVQK
RLSSDIHTRPDFMDSMLRSRHYTYNQNDWKKAPDALTDSEIVSNSNILII
AGSETTATLLSGVTYWILRNPRVLSRVVCEVRSVMKSEADITVQKVSTEL
PYLLACFDEAFRLYPPVPTGLQRRTLAPTFISGYEMPPGTIVSVHQSGAY
RSESNFHLPNNFIPERWLPDAKTNPSSQFYHDNRAVVQPFSVGPRNCIGR
NLAFAEMRVILARVLWNFDLELCKESENWSDQKSKLWAQPDLATEEAIRL
H*
>CYP65T2 Neosartorya fischeri NRRL 181
AAKE02000011.1 NFIA_002780
DS027697.1 complement(627606..628748)
57% to 65T1
MMFVILAAASLLYISYILLLAIKTIYFHPLSHIPGPKWRIGIPLLHHLS
628603
AIRGRLDLDISSWHEKYGDVVRSGPDEVTFITAQAWKDIYGHGHRQLPKVQISAINGKDI 628424
628423
FSANDVDHARFRKALSHAFSAKGLQAQERIVTQYIDKLIQRLKWFAESGTAADMGKW 628253
YNLATFDLIGDLAFGEPFGGLDSA
EYHHWVATMFGFVKSIPFLRALHRYPVVFKVILAFHPGSLMEMRSKQVEHAKATVQKRL
SNSAAGRGDFMDSMLRHQGDKGGLSLDELEENANVLILAGSETTAALLSG
VTYWLLRTPDALDKVMREVRAAFALERDITFNQVTAKLPYMLACLNEAFRLYPPVPGGLQ
RWTEVPTWISGYRVPAN (0)
TKVSVHQLSAYSSLKNFHQADRFIPERWLPEAIEDPASPFFSDNRAVFQPFSIGPRNCLG
RNLAYTEMRVILARVLWTFDLTLCEESRDWKDQKIFVIWERGPLMCKLAMRDDRGDCQGGR*
>CYP65T2P Aspergillus
fumigatus Af293
XP_748490.1
also AAHF01000010.1
58% to 65T1
Nterm aa 52-168 plus C-term part, 84% to 65T2 = ortholog
name revised
from 65T3P
SLRGRLDLDLRSWHEKYDGVVRPGPDEVTFITAQAWKDIYGHGHLQLPKVQISTINGK
NIFATNDVDHARFRKALSHAFSAKGLQAQECLVTRYIDKRIERLKGFTESGTAADMGKW
425909
*NLATFDLIGDVAFGEPFGGLD
AYSSPRNFHQADRSIPERWLPQVIENPASPFFLDNRAVFQPFSIRPRNCLGRNLAYTEMR
MILARGLWTFXX
LCEESRDWTDR
>CYP65T4 Aspergillus oryzae
GenEMBL BAE59716.1
68% to 65T1, 45%
TO CYP65AF1
MPFNILLWPVIAFFLYSLLTAIWYIYFHPLRRIPGPKSWIIFPIMRHASAIRGRFDIDMRQHHAVYGPVV
RFGRDEVSFITAEAWKDIYGHGHQQLPKVLSSASNMLDIISSNDTDHSRYRKALSHAFSAKGLQAQEPLL
NSYVDKLIERLKGIAESNLPADMVKWYNLTTFDIIGDLAFGEPFGGLDNSEYHHWVSTIFESIKAIPFLK
LKDAYPLAFKAILGLIPKGIMEARKRQLEHSRITVQKRLQTSSSYNRGDFMDSMLRNRGEKDSLNDSELE
ANSNILIIAGSETTATLLSGATYWILRNPEALAKLTDEVRSVMKSEPEITAQKASAELPYMLACFDEAFR
LYPPVPTGLQRRTLVPTRISGCDIPAGTKVSVHQSAAYWSSTNFHAPDRFIPERWLPEAKSDPSSPFYSD
NRGVVQPFSTGPRNCIGRNLAYAEMRVILARVLWNFDLELCEESTQWSDQKAYTLWEKPPLMCRLKLRES
FRG
>CYP65T4 Aspergillus flavus
99% to CYP65T4 Aspergillus oryzae
AFL2G_07016 revised
MPFNILLWLVIAFFLYSLLAAIWYIYFHPLRRIPGPKSWIIFPI
MRHASAIRGRFDIDMRQHHAVYGPVVRFGRDEVSFITAEAWKDIYGHGHQQLPKVLSSASNTLDIISSNDTDHSRYRKAL
SHAFSAKGLQAQEPLLNSYVDKLIERLKGIAESNLPADMVKWYNLTTFDIIGDLAFGEPFGGLDNSEYHHWVSTIFASIK
AIPFLKLKDAYPLAFKAILGLIPKGIMEARKRQLEHSRITVQKRLQTSSSYNRGDFMDSMLRNRGEKDSLNDSELEANSN
ILIIAGSETTATLLSGATYWILRNPEALAKLTDEVRSVMKSEPEITAQKASAELPYMLACFDEAFRLYPPVPTGLQRRTL
VPTRISGCDIPAGTKVSVHQSAAYWSSTNFHAPDRFIPERWLPEAKSDPSSPFYSDNRGVVQPFSTGPRNCIGRNLAYAE
MRVILARVLWNFDLELCEESTQWSDQKAYTLWEKPPLMCRLKLRESFRG*
>CYP65T? fragment Aspergillus ochraceus
DQ054597 C-term
piece after heme signature
Involved in
ochratoxin synthesis
See DQ054596 for a
second P450 in this pathway
This fragment is
60% identical to CYP65T5 C-term
FLRAQGTASERNLAYAEMRLIAVKLLWNFDLAFEEECEGWDNQK
SYNIWEKDPLKVKLTP
>CYP65T5 Aspergillus terreus NIH2624
NW_001471196
68% to 65T4,
62% to CYP65T1
ATEG_08832.1
MALQEFLPVVPAISVLYIFLLAIWNLYFH
PLRHIPGPRSWIAFPIMRHISASRGRLDSDMRRFHAQYGGAVRLAPAEVSFITPDAWKTI
YGHGHTQLPKVQTSESKGLDIISSEGPNHTRHRKALAHAFSARGLQAQEPLVRGYVDKLI
ERLKEFAESQLQVDMVKWYNLTTFDLIGDLAFGESFGGLDNSRVHSWVSTIFRSVKVLPF
VRITDTYPILIPLLMALLPKSLRTARRDQTNYSKETVHKRLANTAAHGRGDFMDSMLRHR
GEKDGLSDRELEENASILIIAGSETTATLLSGVTYWLLRSPEALAKVTDEVRSTFQTEGE
ITLQDVGARLPYMLACLDEAFRMYPPVPCALERRVLTPIVIAGYNIPPG
(0)
TVVSVHQSAAYCSPANFHRPQDYIPERWLPDAKSNPSSPYFSDQRDVLQPFSVGPRNCIG
KNLAYAEMRLILARVLWNFDLELCEESLHWKDQKSYLLWDKPPLMCKLKQRI*
>CYP65T6 Aspergillus niger
e_gw1.4.330.1|Aspni1
65% to CYP65T4
MPTILAIVVISYIVYTVCAAIWNIYLHPLHRIPGPKLWLAFPILRYISFMRGVLDRDMRTYHNRYGGAVRFSPNEVSFIT
TQAWKDIYGHGHRQLPKVPGSMNNPMDIISANDSDHTRFRKAISHAFSAKGLQAQEPFIMEYVDKLINKLHSMAKSQVAV
DMAKWYNLTTFDLIGDLAFGESFGGLDSTEYHYWVSTIFEFIKAIAFARFKDNYPMMFQVLERFLPKHLLEAKRRQDEYS
WNTVQKRLHHQRDRGQADFMQSMLRHRGEKDGLTDEELAANASILVIAGSETTATLLSGLTYWLLQHPKEMEKVKFEVRS
VMKTEEDIDVNNATAKLPYMLACIDEAFRMYPPVSGGLQRYVPDTPTEISGYLLPPKTNVSVHQSAAYRSPLNFYRPEEF
IPERWLPQSKNDPSSPFYHDNRDVLQPFSVGPRNCIGRNLAYAEMRVILARVLWNFDIELCEESRDWHDQKSYNLWAKPP
LMCRLKARVH*
>CYP65T7 Aspergillus niger
fgenesh1_pg.C_scaffold_3000290|Aspni1
68% to CYP65T4
MLDPLILAIAPGIYFLYSILSIIHALYLHPLRHIPGPKSWIILPLFRHISAVRGRLDADIHRFHEKYGPVVRVTHNEVSF
NTAEAWNRIHGYGHSELPKVSSSGANPRDIVSANAADHSRFRKALSPAFSAKGLQAQEPLINSYVDKLISRLKDIAESQL
PADMVKWYNLTTFDIIGDLAFGEPFGGLESSQYHYWVATIFQFLKLLPFLKLRDAYPTIFKLIALAMPKTLLNARERQRA
HTRITVQKRLDNASKYDRGDFMDSMLRNSGTKDGLTHEELVANANILIIAGSETTATILCGVTYWLLKSPDALAKVTTEV
RSIMKSETDISVSSVAAKLPYMQACIDEAFRMYPPVPTGLTRMTIEPTLISGYEIPPGTKVFVHPIAAYHSPRNFHAPER
NLPERWLPEAKTDPASPFFSDNREVLQPFSIGPRNCIGRNLAFAEMRVIIARLLWNFDIEICEESKDWSDQKTFTLWEKP
PLMCKLSLRN*
>CYP65T8 Aspergillus clavatus
69% to CYP65T2 Neosartorya fischeri
ACLA_062600
MLHLRERAAIANVTGVVSVLYSARSVIKRAGSFPDVGHDPKYRAVLLDLIVKMFLALGTALALYLGYILASAIRNIYFHP
LRDIPGPKSWIAFPLLQHLSAIRGRLDLDMHHWHIKYGAAVRFDPTSVSFITADAWRDIYGHGHKQLPKVLNSGSNTQDI
ISANDADHTRHRKALAHAFSAKGLQAQEPIVTGYVDQLIARLRDVAASGLPADMVKWYTLTTFDLIGDLAFGEPFGGLES
SEYHRWVAAVFGFIRVIPFLKGMDEYSVLFRVILSFLPRSFLQMRTDQVEHTKRTVQKRLRTRRHDRSDFMDSMLRHRGD
KDGLSEEELVANANILIIAGSETTATLLSGVTYWLLQTPAAMERVTREVRTTFASEAEITFNNVTAQLPYMLACISEAFR
LYPPVPGGLQRWTETPTRISGYEIPGRTKVSVHQAGAYWSSRNFHQPDSFIPDRWLPEAKDDPASSFFSDQRDVLQPFSV
GPRNCIGKNLAYTEMRVILARVLYNFDLQLCEESRDWKDQKTFVLWEKKPLMCRLTARRE*
>CYP65U1 Aspergillus nidulans AN6466.1 37%
to 65B1 53 clan
revised 7/18/07
MGVYLFSSSLWATLLLAILIYRLVRITYNLYFHPLSGIPGPSAWAASRLP
FVYALIRGTIIQDFQKLHEQYGPIIRIAPNEVTFAHPEAYTDIFQPRPEK
SQGQFLKDPLWWARQPGHPDSLLSVINPERHAQMRRVLSPGFTARALRKQ
EPFVQKYVNLLVAQLQDLVSKSPSAHINMTPWFNYTTFDIFGDLGFGESF
DCLQHSRYHPWIALLFDSVKAAGFVIATRYYPLIEAVLLKCVPPSMRKIQ
RDHYQQIVDKVQRRLGWELQRPDFMSYVIDERGGLRLDAGELYATFMILT
TAGSETTATALTGTLNYLVNHSPESLQRLENEIRGAFSGLDAITLDAVRN
LPFLNAVIQEGLRLCPPIPWVLPRLVPQGGSMICGTWLPGGTPVSIQAYT
LNRDPTLFNRATSFLPERWLASSTSDSSSCFFNDQRQVVQPFSTGPRACL
GQHLAWAEMRLILAKLVWVFDFGAIDGQGVNWEDLRTYLLVERKPIN
VRISSRTV*
>CYP65U2 Aspergillus niger
e_gw1.3.403.1|Aspni1
61% to CYP65U1
MAINALSIAISLLVIVCIAFPTWQLFLLQNQLLKLFAQYPISRIVYNVFFSPLSHLPGPISWSATRLPFTRALLRGTIVH
DFERLHRKYGPVVRTAPDEVSFASGDAWTDIYASRPDDRQFLKDPLWWRRQPGQPDTLLSAIHPAKHSRMRKLLAPAFTP
RALRVQEAVLQRYASLLVDRIKDQVSVAGTDGAVIDMGPWFNFTTFDIFGDLGFGESFNCLQHSQYHPWIVLLFGSVKAA
SFIAAARYYPPLEALLMKCIPRSLHEKSQRHYRQIINKIDRRLSWELQRPDIMSHLMDENGQVALPRGELNSTFMILTTT
GSETTATVLTGILTYLVNQPEVLGRLIGEIRGRFGSSQDISLSEAADLPYLTAVIQEGLRLCPPVPWMLPRQVPPGGSTV
CGTWLPGGTAVSLQAYTLNRDPSRFHAASSFLPERWLPDASSNPNSNFYQDDRHAVQPFSMGPRSCLGQHLAWAEMRLIL
TKLLVNFDFEAVEGKQLRWEELRTFLLVEKRPLEVRVRLA
>CYP65V1 Nectria haematococca
gw1.24.106.1 model short on N-term
Necha1/scaffold_24:57028-58643
MLFALAL (0)
AILYLLGSIFYNLFLHPLRKIPGPFWMRATRATYCYKLVFGTLPFD
MLDLHNHYGDVVRIAPDELAFSGREAW
KEIMGHRIKDNKRPTFEKYDQFYRPNGGPTDIANSSGTEHQVLRRLLSHGFSDRSLRDQEPIVKKYVDLL
IQRLHENSDRPLDIMSWYNYTTFDVIGDLAFGEPFGCLDNSDYHPWVRIIFEVARFGTVNQTAGYFPLLR
SLLTRILSSKAVRSRGESHRALTREKMLRRVELGKNGGRPDLIDNLLKKSEEL
(0)
GITEAQLLKNCGALIIGGSETTATLLSGVTYLLLKTPEALHKLTGEVRSAFETEDEINFTSVN
KLTYMLACLDEAFRVYPPIPGGLPR QIPKGGSEVSGRFIPGD (0)
TVVAIHQWAMYHSEKHFRDPFNYHPERFLGDSNFESDHRDVLQPFHVGPRNCLGRN
(2)
LAYVEMRVILARIIWNFDLSLAEESQDWLQRQK VYIFWDKGPLIVNLTP
(0)
RV*
>CYP65V2 Aspergillus oryzae
GenEMBL
BAE61720.1, AP007163.1
53% to 65V1, 43%
to 65B1
revised 3/20/2009
with a frameshift
MMLNSINIPQNAISWAVACAAA (0)
198235
ATFCLASSVVYNIFFHPLARYPGPLSHAASRVPYFIRVFKGTLPFD
MLDFHTRYGDVVRIAPDELAFSHPDAWKDIMGHSKGGLYLEKASWFYRP
LEYDPPHIFNEGRQAHSLLRRQLAHSFSDKGMRDQEPMIRGYVDLLLQRLREMGGREDTVDISAWYNYTT
FDIIGDLSFGESFGCLKGSNYDEWIESIFRAFPFITALQALSFTPLVKEVLLALVPPSMRDRRERLRDFT
RQKMLRRMAIAEERPDLIEGLLKKKEEL (0)
GLTIDKLTA &
AETLVVAGSETTATLLSGVTYLLLKNPEAYQ 199191
RLREEVRSTFSSEDDINLSSAAKLPYMLACVEEALRMYPPGAIGPPRVTPKGGAEILGARIPGR
(0)
TYVSIHHWALYRREEYFTDPHTFHPERFLGDPRFSNDRHNVLQPFHIG
PRSCLGRNLAYSEMRLILALLFFNFDMELSDDSQDWIQQKNVIMWQRGPLKVHLTYIHRNSA
>CYP65V2 Aspergillus flavus
99% to CYP65V2 Aspergillus oryzae
AFL2G_09433
MLNSINIPQNAISWAVACAAAATFCLASSVVYNIFFHPLARYPGPLSHAASRVPYFIRVFKGTLPFDMLDFHTRYGDVVR
IAPDELAFSHPDAWKDIMGHSKGGLYLEKASWFYRPLEYDPPHIFNEGRQAHSLLRRQLAHSFSDKGMRDQEPMIRG
YVDLLLQRLREMGGR
EDTVDISAWYNYTTFDIIGDLSFGESFGCLKGSNYDEWIESIFRAFPFITALQALSFTPLVKEVLLALVPPSMRDRRERLRDF
TRQKMLRRMAIAEERPDLIEGLLKKKEEL (0)
GLTIDKLTANAETLVVAGSETTATLLSGVTYLLLKNPEAYQRLREEVRSTF
SSEDDINLSSAAKLPYMLACVEEALRMYPPGAIGPPRVTPKGGAEILGARIPGR (0)
TYVSIHHWALYRREEYFTDPHTFHPERFLGDPRFSNDRHNVLQ
PFHIGPRSCLGRNLAYSEMRLILALLFFNFDMELSDDSQDWIQQKIVIMWQRGPLKVHLTYIHRNSA
>CYP65V3P Aspergillus oryzae
GenEMBL
BAE55600.1, AP007151.1
Gene model
has wrong C-term, revised
about 60% to
CYP65V2, 48% to 65B2, 54% to 65V1
one stop
codon and one frameshift in last exon
MSTAALVNAKSVLIATISA (0)
PIIYMLGMAIYNVYFHPLNRFPGPVSHAISRIPYFYRAVRGTLPFD
MLKLHERYGDIVRIAPDELAFSHPDAWKDIFGHKNGEPEMAKAAWFYRPLDDPLHIVNEDTDEHRRLRRQMAHGF
SEKSMRAQEPIIRKYVDLSLEKLHQSCKNGSLVILDWYNFTTFDIIGDLAFGEPFGCLEGCNYDQWIKGI
FKGAYLGSFMQALSFVPRLKSTLLLLVPKSMQEAHQGHKALTKAKMLRRAAITEKRPDLIDGLLRNKDEL
1455183
KLGLDKLIANAEILIIGGSETTASLLSGVTYLLLQNPNAYETLKNEVRSKFNHQEEIN 1455356
LISVNKLSYILA
CLDEALRMYPPIANGLPRVCPKEGSWVLGEYIPGKTVLSIHQWALYRREKHFKDPNTYHPERFLSSPEFL
DDRRDAFQPFHTGPRNCLGRN (2)
LAYS*MRLILALVIFNFDMKIAAESK &
DWIRQRNYLMWDKGPLKVYLRPRTSI*1455965
>CYP65V3P Aspergillus flavus
98% to CYP65V3P
AFL2G_00556 gene model revised, one frameshift
in last exon
MSTAALVNAKSVLIATISA (0)
PIIYMLGMAIYNVYFHPLNRFPGPVSHAISRIPYFYRAVRGTLPFDMLKLHERYGDIVRIAPDELAFSHPDAWKD
IFGHKNGEPEMAKAAWFYRPLNEPLHIVNEDTDEHRRLRRQMAHGFSEKSMRAQEPIIRKYVDLSLEKLYQSCKNGSLVI
LDWYKFTTFDIIGDLAFGEPFGCLEGCNYDQWIKGIFKGAYLGSFMQALSFVPRLKSTLLLLVPKSMQEAHQRHKELTKA
KMLRRAAITEKRPDLIDGLLRNKDEL (0)
KLGLDKLIANAEILIIGGSETTASLLSGVTYLLLQNPNAYETLKNEVRSKFNHQ
EEINLISVNKLSYILACLDEALRMYPPIANGLPRVCPKEGSWVLGEYIPGK
(0)
TVLSIHQWALYRREKHFKDPNTYHPERFLSSPEFLDDRRDAFQPFHTGPRNCLGRN
(2)
LAYSEMHLILALVIFNFDMKIAAESK &
DWIRQRNYLMWDKGPLKVYLRPRTSI*
>CYP65V4 Aspergillus niger
e_gw1.11.216.1|Aspni1
70% to CYP65V3P
MTLPDIFYHPPADDHDSTHHAHNNRSNATERERGVGGTCFRGNGPSLVYNICDAQSNLAAQVTIYYATQIIYNVFFHPLS
RFPGPISHAISRLPYCYYALIGTLPFHMLDLHNQYGDIVRIAPDELAFSHPNAWKDIMGHKNGEEELGKADWFYRPLPEA
RHIVNEERDQHKGLRRAMAHGFSEKAMREQEPLIRKYTDLLLERLREQSKSGQSVAISDWYNFTTFDIIGDLAFGEAFGC
LENAKYDYWIKTIFESGRLGIILQSISFYPILKSLLLLLVPKSLQEAQQKHKALTTTKMLRRLAILEDRPDLINSLLKKK
EDLALTMDHLIANAEILIIGGSETTASLLSGVTYLLLQNPDAYQNLRDEVRSTFRKQDEINLISVNKLTYMLACLDEGLR
MYPPIANGLPRMCPRGGCTVLGHYIPENTYVSMHQWALYHREKHFTDPESYHPERFMGSPQFANDRRDVLQPFHVGPRNC
LGRNLAYSEMRLILALIIFNFDMVISEDCDDWIQQKNFLMWQKRPLKVYLKPVPRDNP*
>CYP65V5 Histoplasma capsulatum
ABBT01000064.1 Ajellomyces capsulatus G217B
55% to CYP65V4
HCB02008.1
254348
MAVIVKIQALTQSPVILAATSLSIVVLYLISRFIYSVFFHPLRSFPGPTSHAMSQIPYIYKSLRGTLEFDILDLHKTYGD
IVRIAPNELAISGPGAWKDILGNRRSGEEQLEKFQQYYRPTGGKKATSIINADRDDHSRLRRQLAHGFSDKSMREQEPLI
TQHIDLLVKRFHERGRGGSKPFDLTQWYNYATFDVIGDLTFGESFGCLENAYFHPFVKLMLASGKIAVFLQCLSFFPLAKETFLNLIPR
SALKSQANVAKE
KILRRMQMGIERPDLIEGLLKKKDEWNMSLDALSGNARLILVGGSETTATLLCGVTYLLLSNPQTLERLTAEVRSAFKSE
DEINMSSVNDLNYMLACLDEALRVYPPVPLGLPRVVPKGGCEITGQFIPEDTVVAVHHWATYHNEKYFTDPFAYHPERFL
GDPKYASDKRDLLQPFHIGPRSCLGRNLAYAEMRLILARLIYNFDMRLAKESADWLAKQKVFLFYTKPPLNVYMTPVNSRE
256403
>CYP65V6 Aspergillus terreus
57% to CYP65V5
ATEG_02650.1
MAVLTGDPSSLLAVAVGL (0)
VIVHITAKALYNIFFHPLRSFPGPPSHAAFRFPYCYK
LLRGTFPFDMLSLHRQYGDVVRVAPNELAFSHPDAWRDIMGHRIDGSDEMGKWDQFYRAVPQTPTSIVSADRTEHGALRR
QLSHGFSERAMRAQDPLITGYVDLLIQRLHENCRGGAQTVDMTAWYNFTTFDIIGDLAFGQPFGCLEKSEYHPFVPLLFK
SSRMGSVVFSLSFYPMLKKLVFAMIPKSLIQLFEDHRQVSIEKLRERMKLEVERHDLIEGLLRKKDDLVCLG &
MDHLEANANVLLIAGSETTATLLSGVTYLLLMNPEALSRLTEEVRDAFNSEAEIDMQS
VSRLPYMLACLDEALRMYPPVPNGLPRVVPKNGAQIAGKFV ()
QTPVAIHHWASYHNEKYFADPFNFHPERFL
GDERFANDRFDILQPFHVGPRNCLGRN (2)
LAYTEMRLILARVIYNFDMKLADDSTDWLKRQKVWFFWNRPALNVYLTPVKR*
>CYP65W1 Nectria haematococca
e_gw1.5.258.1
Necha1/scaffold_5:405215-406714
MLAIGLWLLAALPLL (0)
ALLKIIYNVLLHPLRHHPGPKLWASTRIPWCWNQYQGKLNHRLVELHHQYGPAVRVAPDEVSYTSDTAWKTIY
GHRSVEMTKDPIFSLVTPTGVP (1)
NIVTADRVNHSRHRRLLSHAFSEKALREQEDILVQYCTKLLDQLQARCSDGPLDLAKWFPLT
(1)
TFDLIGSLAFGQDFSCIDTGEPHPFVACIKGVSRELVMSQMAQYYGFGSLRYFLFL
RGSANSRFANAMRAKEMVEARIARGPTDDRKDFWHHVLAAEDQGKGLTPDEMVVDAFSIAIAGSDGTATA
LAGTTYLLLTHRDVYQQLQGFIRQEFEAEEDITTLALSNERVPLLGAVIQESIRLFPPVAATLPRVVPPS
GETIDGLFVPEGTIVGVNQLAAYHSEKNFNQASEFLPERWLSEQGDCRAVFQPFSFGPRNCLGKNLAKAE
LRLILARMLWRFDMELLPESQGWMDGQKIYGFWIKPPLMVKLSPRAN*
>CYP65W2 Aspergillus niger
fgenesh1_pg.C_scaffold_14000165|Aspni1
53% to CYP65W1
MALIQVVGSDSMFWLGAVALTSLLAWVILHVCYNAFLHPLRQYPGPRLWAATRLPWCWYQAHGRLNQKLLELHLRYGRIV
RVAPNELSYNSEEAWRAIYGLRSDEMGKDPVFSLRTPTGVQNILTADRQTHTRQRRLLSHAFSEKALREQEGIIQGYVDQ
LMKQLAARANDGPQNMVDWFTFTAYDLIRDLSFGERFHCLDTAEYDPFVRSIQAISKELTFIQMLAYYKLLSLRQLFMSK
AFSGARAQNMQRVIETVNRRVDRNTDRKDFLHYILAAMETEKGMSRAEMNVNAFSFSIAGSESSATALSAFTYYTLSRVS
VYDRLIAEIRGTFDAYEQIDISSTAQLSYLNAVLQETLRIYPPVAVTLPRVVPVNGTVIDGDFVPAGVTVGVNHFACYHD
PRNFHRPQEFLPERWLPECQAQGPFSKDCQKSCQPFSFGPRNCLGKNLAWAEMRLIAAKLLFLFDMEIDETSKGWTDGQK
VLGFWVKPPLFVRLMQRGC*
>CYP65X1 Aspergillus oryzae RIB40
AP007157.1c genomic DNA, SC023
join(331674..331760,331832..332607,332687..333038,
333095..333264,333318..333474)
third P450 gene in a set of 8 on this accession
42% to CYP65S2, 40% to CYP65S3, 42% to 65A1
MALAAEYFSHALSQPYGSSFWVAVAASLVFICYITCDTVYNLCL
SPLSSFPGPRLWAVSNIPRQLSILGGRSHLKMLALHHRYGPVVRVGPSELSFNSPQGF
RDIYGFRRGQPQFQKDPKMYGSPLTGISNSIGGHVDSDTHSRHRRLLSHSFSERSLRE
QEGIVVYYVDLFIQRLRERTSVNKIHRAEEDLKSWFNFTTFDIIGDLMFAETFDCLKD
SQLHPWIALMFNNVKGIAFLGVLNEYSLFRKMQGALLPKALKQKMLENHKLCAQKADR
RLQKGASRPDFVSAILKHGLSDDKEEFIENQPLMSRAEIHANSIF
(2)
ITIAGSETTASLLSGCLFYLC
KHKYIMDQLNKEIRTTFSKDEEITSSKCFNLSYLNAVLKESLRLYPPVAASLLRLVPK
GGCTIDGHFVPED
VTVSTHHYASYRDAANFTFPEQFIPERWLGTDNRFDSDRKDVVQP
FSLGPRDCLGKNLAHMEMRLILSKLLFNFDIHLTPESENWGQQKMFIVWDKPALMVRL
TDRFA
>CYP65X1 Aspergillus flavus
99% to CYP65X1 Aspergillus oryzae, 48% to CYP65AU1
AFL2G_04023
MALAAEYFSHALSQPYGSSFWVAVAASLVFICYITCDTVYNLCLSPLSSFPGPRLWAVSNIPRQLSILGGRSHLKMLALH
HRYGPVVRVGPSELSFNSPQGFRDIYGFRRGQPQFQKDPKMYGSPLTGISNSIGGHVDSDTHSRHRRLLSHSFSERSLRE
QEGIVVYYVDLFIQRLRERTSVNKIHRAEEDLKSWFNFTTFDIIGDLMFAETFDCLKDSQLHPWIALMFNNVKGIAFLGV
LNEYSLFRKMQGALLPKALKQKMLENHKLCAQKADRRLQKGASRPDFVS
AILKHGLSDDKEEFIENQPLMSRAEIHANSIF
ITIAGSETTASLLSGCLFYLCKHKYIMDQLNKEIRTTFSKDEEITSSKCFNLSYLNAVLKESLRLYPPVAASLLRLVPK
GGCTIDGHFVPED
VTVSTHHYASYRDAANFTFPEQFIPERWLGTDNRFDSDRKDVVQPFSLGPRDCLGKN
LAHMEMRLILSKLLFNFDIHLTPESENWVQQKMFIVWDKPALMVRLTDRFA*
>CYP65Y1 Aspergillus fumigatus Af293
GenEMBL
XP_746900.1
49%
to CYP65V1, 88% to CYP65Y1 Neosartorya fischeri
revised 3/12/2009 added N-term, one stop codon
MGVGSDKG*VVCYVITQAVYNVFLHPLSRFPGPLLHRASRLAYVYRLIGGTLTLDALE
MHQRYGDIVRVAPDELFFAHPDAWSDIHKKTGREMDKAPWFYRPLEQSPRCIVDESHEQHSRLRRQMAPG
FSEKSMRDQEPIIRGYVDLLLQRLLEKSNDGQPVVISDWFNYTTFDIIGDLVFGEPFECLGSSKYDGWIK
SIFESLRPLTIVQALSFFPWLKRIALDTVPKNLQGDIKQQQQQTEAKMRRRMAVTASRGDLMEGLLKKKD
ELHLSTEELIGNAQVLILAGSETTASLLSGVIYLLLQNAVAYRQLVDEVRSTFNSEKDINFVSVSQLSYM
LACLNEALRIYPPVANGLPRVVPKGGAQILGQYIPEQTYVAIPQWALYHREQYFAEPNDFHPERFLGDPK
FANDRRDALQPFSVGPRNCLGRNLAYAEMRLILALVIFHFDMKIDPDCRDWIQQRNFTLWQKPPLKVYLK
PVARKSEPNQV
>CYP65Y1 Neosartorya fischeri
88% to CYP65Y1 Aspergillus fumigatus = ortholog
NFIA_112820 revised
MGVSSDKGQVVCYVITHAVYNVFFHPLSRFPGPLLHRASRLPYFYGLIKGTLTIDALE
MHQRYGDIVRVAPDELFFAHPDAWSDIHKKTGKAMDKARWFYRPLEVTPRSIVDESHERHSRLRRQMAAGFSEKSMRDQE
PIIRGYVDLLLQRLREKSNDGQPVVISDWFNYTTFDIIGDLAFGEPFECLKSSKYHGWIRSVFESSRPLAVVQALSFFPW
LKRIVLDMVPKDLQETFKRQQRHTEAKMRRRMAVTGNRVDLMEGLLKKKDEFNLSIDELITNAQVLILAGSETTASLLSG
VIYLLLQNSVAYQQLVDEVRSTFSSEKEINFVSASQLSYMLACLNEALRMYPPVANGLPRVVPKGGAQILGQYIPEQTYV
AIPQWALYHRKEYFAEPMDFHPERFLGDSRFANDRRDALQPFSVGPRNCLGRNLAYAEMRLILALIIFNFDMKIDPDCRD
WIQQKNFTLWQKPPLKVYLKPVARKSEP*
>CYP65Y2P fragment Histoplasma capsulatum
G217B
C-term pseudogene of CYP65Y sequence 67% to
65Y1
ABBT01000195.1 Ajellomyces capsulatus G217B
HCB05094.1
ERFLGDPKFANDKRDMIQPFHVGPRNCLGRN (2)
LAYAEMRLILARLIYNFDMKLAPESANWMRKQRVFLFYTKPALNVYMTPVKR*
131686
>CYP65Z1 Aspergillus fumigatus Af293
GenEMBL
XP_751828.1
41% to 65R1 Fg,
44% to 65S3
MAPWNHDIFDRLMLSAILSWSILLQSQIANYRRRTLTRRQGCVYLIGHSIYAIYFHPLSRYPGPKIAAIS
PIALLVWEIRGKVHSKVKHLHDRYGDVVRIGPNALVYRAPRAWKEIYGYRTKKGQRTFQKDPSLYVPTPN
GVHAIITAAESDHIRMRRLLAHAFSDRALREQESLLHFYADLLVQKLHENLNHSHSEVVDIARWYNFTTF
DLIGDLAFGEPFQCLKDSKYHWWVSIMLDAVKLSVYLKVLWFFPILSPLTKLLVPRYLHQRREASFQLTV
EKVSRRLHRQTNRPDFISYILRHKDDENRMSRQEIDANAATFVLAGSETTAALLSGCTFYLLKNPHIYRR
LVTEIRSRFQHPSEIRLSSIATLSYLNAVLEESLRIYPPIPAMLPRLVPEEGAMINGEYVPAGTSVSMSL
WSTFHSSGNFHNPDSFVPERWLASPEEEASRCFTMDKKEAFQPFSYGPRNCLGQHLANAEMRLILAKVFW
HSDMELCPESENWADQESYNLWSRPPLMVMISRANGRNYEDNMV
>CYP65Z1 Neosartorya fischeri NRRL 181 XM_001267015
94% to
CYP65Z1
name revised
from CYP65Z3
NFIA_106070
MLTRQQGSIYLIGHSIYAIYFHPLSRYPGPKIAAISPIALLVWE
IRGRVHSKVKDLHDRYGDVVRIGPNALVYRTPQAWKEIYGHRTKKGQRTFRKDPSLYV
PTPNGVNAIITAAESDHIRMRRLLAHAFSDRALREQEPLLHFYADLLVQKLRENLDHS
HSEVVDIARWYNYTTFDLIGDLAFGEPFHCLKDSKYHWWVSIMLDAVKLSVYLKVLWF
FPILSPLTKLLVPSYLHQRREASFQLTVEKVSRRLHRQTNRPDFISYILRHKDDENRM
SRQEIDANAATLVLAGSETTAALLSGCTFHLLKNPHIYRRLVTEIRSRFQHPSEIRLS
SIATLSYLNAVLEESLRIYPPIPAMLPRLVPEEGAMINGEYVPAGTSVSMSLWSTFHS
SANFHNPDSFVPERWLASPEEETNRCFTMDKKEAFQPFSYGPRNCLGQHLANAEMRLI
LAKVFWHLDMELCPESENWTDQESYNLWSRPPLKVMISRADGRYEEDSMV
>CYP65Z2P Aspergillus fumigatus
87% to CYP65Z2 Neosartorya fischeri
supercontig 2 3641455-3643345 region
MSPVSIVLSL (0)
LVAVLLGQVIYNI &
VIYLQPLRKSPGPKLVACSNICYIWWTFSGEIHAKLKELHDQYGDVVRISP
&
STLVYRSPGAWKDIYGHRKHGVNSFIKDPEFYNPSPNGGHILTAGDADHARQR
RRLSHAISE &
KTLREQESLVLHYVDLLVEKLRAECAAARSTVDMMKWYNYTTFDIFGDMAFGELLNCLRD
NRYQPWVVMVYQSVKMSIDLRLIHLYPLLESLATRLL &
PKKAAEMRNEHWRMSKDKVGHRLDLQATRPDFLRHNDERGMTRQEIEENAGVL
ILAGSETTATLLSGCPFYVLKHPEKYNKLVQEIRGAFQKQEDITFLSVARLPYSHAVLEE
SLRLYPPVPGYLPRKVPMGG &
ASIDGQYVPEG (0)
ISVSVVPFLA
SRAKSNFVEPESFIPERWLENRYPRFETDHREASQPFSFGLRNLLGK
(2)
NLAYAEMRLIVAKLLWNFDMTLYEGCRDWGDQTSYIIW*KPSLMVELKAVR*
>CYP65Z2 Neosartorya fischeri NRRL 181
XP_001260852.1, NFIA_089120
56% to CYP65Z1 Aspergillus fumigatus Af293
76% to CYP65Z5 Aspergillus clavatus
MSPISIVLSILVAVLLGQAIYNIYLHPLRKFPGPKLAACSNICY
IWWTISGEIHAKLKELHDQYGDVVRISPSTLVYRSASAWKDIYGHRKHGASSFIKDPE
YYIPSPNGGHILTAGDADHARQRRLLSHAFSEKAMREQESLVQHYVDLLVEKLRAECA
ASRSTVDMMKWYNYTTFDIIGDLAFGEPFDCLRDNRYHPWVKMVFQSVKMSVYLRLIH
LYPLLESLVKRLLPKKAAKMRNEHWRMSKDKVSRRLDLQTSRPDFMSCILRHNDERGM
TRQEIEANAGVLILAGSETTATLLSGCTFYLLKHPEKYNKLVQEIRGAFQKQDDITFL
SVARLPYLHAVLEESLRLYPPVPGYLPRKVPMGGASIDGQYVPGGVSVSVVPFSASRA
KSNFAEPESFIPERWLENRDRRFETDNREASQPFSFGPRNCLGKNLAYAEMRLIVAKL
LWNFDMTLHEDYRDWDDQTSYIIWQKPSLMVELKAVR
>CYP65Z4 Aspergillus clavatus
81% to CYP65Z3
ACLA_049200
MAFWLHYILESISLWAIFKLGLLVALSYLAPHSIYAIYFHPLSQYPGPKLAAISPIPLLVWEIRGIVHSKVKDLHDQYGD
VVRIGPNALVYRTPQAWKEIYGHRTRKGQRTFAKDPALYVPTPNGVNAIITAPESDHIRMRRLVSHAFSDKALRDQEPLL
HTYADLLVEKLQACIESSRSGVIDITRWYNYTTFDLIGDLAFGEPFDCLKDSKYHWWVSIMLDAVKLSVYLKILWFFPFL
APLTKLLVPRSLHQRREASFQLVVDKVDRRLQRQTDRPDFISYILRNKDDESRMSREEIDANAATFVLAGSETTAALLSG
CTFNLLKNRRVYERLVSEVRDRFQDPAEISLSSIATLPYLNAVLEESLRIYPPIPAMLPRLVPEEGAMINGAYVPAGTSV
SISLWSIFHSSTNFAEPDAFVPERWLKNQADENEADNPFAGDKKEALQPFSYGPRNCLGQHLANAEMRLILTKVLWHFDM
DLCPESEDWAEQESYNLWCRPALNVKLSAADGGNRETMM*
>CYP65Z5 Aspergillus clavatus
76% to CYP65Z2
ACLA_073680
MTSMSMSHLLEPLSMVCGIILLVSPLSLAFAVKTLAVPVAQSLYNIYFHPLRRFPGPKRASCSNVCYLWWTVSGTIHWKL
KELHDQYGEVVRISPSILVYRSPNAWRDIYGHRKHDTTSFVKDPDYYIPSPNGEHILTANDADHARERRLLSHAFSERAL
REQESIVQQYVNSLILKLQEYAASGSAVDMAKWYNFTTFDIIGDLAFGEPFDCLRDNRYHPWVWMIFQSAKASVFMRLLH
LYPRLESLVKKMLPKKFVRMRNEHWQMSKEKVGRRLSLQANRPDFMSYILKYYDERGMSRQEIEANAGVLILAGSETTAT
ALSGCTFYVLKNPEVYNRLVREIRTSFQRQEDITFLSVARLPYLHAALEESLRLYPPVPGILPRKVPAGGASVDGQYVPG
GVTVSTASFSAARAKSNFADPDSFIPERWLKNRDPKFESDNREASQAFSLGPRNCLGKNLAYAEMRVIIAKLLWNFDLSL
HSDCYDWDNQASFIIWQKPALMVDLKPIRG*
>CYP65AA1 Aspergillus fumigatus Af293
GenEMBL
XP_749877.1
43% to 65S2,
40% to 65Z1
MSFLMESSAVGQPSPLSFSNTLNALPGAL ()
VLYAALHSLYNIYLHSLSRFPGPKLWQTSYIFRHIASIRGT
LDVSIKAFHTEYGPVVRYSPDELSFISAEAWRDIYGFRENALPKDPSFYGLIQLSRDKSPSIFTVDQDHH
PRVRKALSYAFSEKALHDQEPFVKHYVDLLIQRLRGIADAEDNRVDLVKWYNFTTFDIIGDLAIGRSFDC
LQDSAYHSWVDAFWKSIKMISPYARAMATYTDVPRLLRLFAPRALKEARLRRLQYVGVHMEERLARGILR
DKPDFISYILRSKGTADELTDGEVEANVSFLLLAGTETTATALSGTTYYLLKNPEGLRKATAEVRSAYNS
EDEITFATTAERLPYMQACLTEGLRIYPSGPIAAPRRTPRGTVTWIAGHPVPPVGGASNSPLNFHRQADF
IPERWLSPSTMDPASPFRRDNRAASQPFSVGPRNCLGKAFALNEMQVILARMLWNFDMKLLPQSDGWERQ
RIFTLWDKGPLMVELNEVRSSLHNQLFLQVCMVVCMVVHQSRSLQRAVHSSGPARNLTG
>CYP65AA1P Neosartorya fischeri
NFIA_074000
C-term is missing
92% to CYP65AA1 Aspergillus fumigatus
downstream gene is a polyketide synthase
both genes are broken and fused at YNSE/PVEP
PVEP is about aa 410 in the A. terreus PKS
gene XP_001215858
The high conservation (92%) suggests an
assembly error rather than a deletion creating a pseudogene. CYP65AA1 in A
fumigatus is upstream of a short PKS gene on AAHF01000007
MSFLMESSAVGQLSTLNFSNILQALLGS (0)
LVLYAALNSLSNIYLHPLSRFPGPKLWQTSY
IFRHIASIRGTLDVSIKAFHAKYGPVVRYSPDELSFISAEAWKDIYGFRENALPKDPSFYGLIQLSRDKSPSIFTADQDH
HPRIRKALSYAFSEKALRDQEPFVKHYVDLLIQRLRGIADAEDNRIDLVEWYNFTTFDIIGDLAIGRSFNCLQDSAYHSW
VDAFWKSIKISPYARAMASYTDVQRLLRLFAPRALKEARLRHLQYVGVHTEERLARGILRDKPDFISYILRSKGTADELT
DGEVEANVNFLLLAGTETTATALSGTTYYLLKNPEVLRKATAEVRSAYNSE/
begin PKS gene
>CYP65AB1 Aspergillus oryzae
GenEMBL BAE56591.1
41% to 60A2,
39% to 60A5, 40% to 60B3
43% to 65S1,
40% to 65A2, 41% to 65B1, 44% to 65H1
47% to 65S3
Supercontig
5: 63753-65569 (+) strand
Revised
3/18/2009
MLFSLGPLTIVYGLVIFVVAKTIYNLYLHPLRSYPGPLLARATRWYYSYYVKIGLLPQKTKELHDQYGPC
VRIAPDELSYNTAEAWEDICGHRTGQRTESFEKDLTFFPPAPNGVDSI
IVAKDDVHRRFRRLLSHPMSDKA
LGSQQEIITGYVDQLIHELRQRSERSEVVDMVRWFNFTSFDILGDLAFGESFGCLGSGLMHPWIELIFTS
IKSVMDMQIIRRIPGLFSLILTIAGLQQKQDLQEQFMFCQKKARERYTKETTRPDFMTYILRATEEKGMT
PEEIEANAQILIMAGSETTASALSGTLFYLLKNSMAMQKLRQEIHATFQAEAEITMRSTQSMEYLHAVLQ
EAMRVYPPVPCTFPRTTPPGGAMVCGRFVPGGYIVGVNQLAAMTSEKNFKDPLKFIPERWCGDERYQEDS
RKAYQPFSYGPRNCLGKNLAYAEMRLVLTRLLWNFEFDLLEESKDWHAKQKVWMMWDKGDLKVRLKPLRH
>CYP65AB1 A. flavus
Supercontig 8: 73235-75051 (+) strand
AFL2G_07276 revised
MLFSLGPLTIVYG (0)
LVIFVVAKTIYNLYLHPLRSYPGPLLAR
ATRWYYSYYVKIGLLPQKTKELHDQYGPCVRIAPDELSYNTAEAWEDIC (1?)
GHRTGQRTESFEKDLTFFPPAPNGVDSI (0)
IVAKDDVHRRFRRLLSHPMSDKALGSQQEIITGYVDQLIHELRQRSERSEVVDMVRWFNF
TSFDILGDLAFGESFGCLGSGLMHPWIELIFTSIKSVMDMQIIRRVPGLFSLILAIAGLQ
QKQDLQEQFMFCQKKARERYTKETTRPDF ()
MTYILRATEEKGMTPEEIEANAQILIMAGSETTASALS ()
GTLFYLLKTPTAMQKLRQEIHATFQTEAEITMRSTQSMEYLHAVLQEAMRVYPPVPCTFP
RTTPPDGAMVCGRFVPGGYIVGVNQLAAMTSKKNFKDPLKFIPERWCGDERYQEDSRKAY
QPFSYGPRNCLGK ()
NLAYAEMRLVLTRLLWNFEFDLLEESKDWH AKQKVWMMWDKGDLKVRLKPLRH
>CYP65AB2 Aspergillus clavatus
82% to CYP65AB1 Aspergillus oryzae
ACLA_066730
MLFPVETLTIVYMLGVFALLKTFYNLYLHPLRSYPGPWLARASRWYYSYYLKRGILPQKTKEWHDRYGPCVRIAPDELSY
NTAEAWEDICGHRTGERTESFEKDLTFFPPAPNGVDSIVTVHRRFRRLLSHPMSDKALNSQQDIIGGYVDQLIHELRRRC
DEPGVVDMVRWFNFTSFDILGDLAFGESFGCLGSGVMHPWIELIFTSIKSVMDMQIIRRVPGLFTLILTVAGLRQNQDLQ
DQFMFCQKKARERCSKETSRPDFMTYILRATEEKGMTQEEIEANAQILIMAGSETTASALSGTLYCLLKNPSALQKLRAE
IHAAFQHESDITMRALQGLEYLNAVLQESMRVYPPVPCTFPRTTPRGGAMVCNRFVPAGYIVGVNQLAALTSAQNFARPL
QFAPERWLGDEQYQHDIRKAYQPFSYGPRNCLGKNLAYAEMRLVLTRLLWNFDLELMPESEDWHSQQKIWMMWDKGPLNV
RIRRLRP*
>CYP65AC1 Aspergillus oryzae
GenEMBL
BAE59505.1 AY510452.1
58% TO
CYP65AC2, 45% to 65U1
MSQFAREIVRNAIYNTSSPDADSVSLRKATTTVLLIGVT (0)
YCILVGIYRVTLHPLAKYPGPKLAAVTRLWHSYHLCTGDIVSVLSRAHEAYGPVLRIAPD
EVLFISSRAWDDIYGARPGKPE
MDKDTPLYKGPTAPHSIVTVDGELHRFYRRLLAKGFSDAALREQEPVIQRNINLLVEKLHKEVAAGKTPE
MTAWFNYATFDLIGELAFGETYGCLENSHYHPWVEMILEVMKLRAMTHAVGYYPWIFHILMWFVPKSLRE
KFVTHRRYTHDKVQRRMDQKIHYKDLTTNLVDPQNGLERYEIDGNCSTLIIAGSETTATALSATLYFLTQ
NENAKRKVIGEIRTTFNNAGDINSISVNQLKYLSACMNEALRIFPPGPAVFPRRVPQGGDFIDGHWIPGG
TQVGIAHYCINRSRRNFVDPDKFIPERWLGDPTYQTDDRHAVQPFSYGPRNCIAHNLARLEMRLVLARLI
WEFDWELAPGSERWEEEALVFNVWSTKPLMIKFTPVAR
>CYP65AC2 Aspergillus oryzae
GenEMBL
BAE54634.1, AP007150.1
40% to 60A2
(CYP60 is in the 65 family)
revised
3/20/2009
MTLSAESSQLPWALGNIVQQVHGIPIWGTVLTILVLVVL (0)
HYAIYAVYNITFHPLAKYPGPKVAAMTRIVYTSHLLSGRLVEFLHQTHLKYGAVVGVAPN
EVIFTSSQAWNDIYNVRQGAPE
MSKDTPLYQSLGTPPTIAEAGHDLHRRYRRLLAKGFSEAGLREQEPVIQQKISVLIKQLHAATAKGTTPE
MTSWFNFFTFDLISELTFGESFKCQENGRFHPWILMVTQSIKFRAIIQALGYYPLLFKLFMGLIPKSYQE
AFRDHQKLTSENVQRRIDKKVDYTDLASNLIDPKHNLERYEIDGNCAVLIVAGSETTTTALSATMYYLTQ
NPEAKAKVIKEVRSSFSSAEEITAISVNQLKYLPACFNEAMRKLPPAPAVFTRRVPREGAYIAGNCIPGG
THVGMCHFATNNSSLNFKDPEKYIPERWLGDPEYEDDARAAMQVFSVGPRNCIGQNLARLELRLLLSRVI
WEFDWELDSASMDWDKDMPVYLSWGMKPLKFHFAPVVR
>CYP65AC2 Aspergillus flavus
98% to CYP65AC2 Aspergillus oryzae
AFL2G_10525
MTLSAESSQLPWALGNIVQQVHGIPIWGTVLTILVLVVLHYAIYAVYNITFHPLAKYPGPKVAAMTRIVYTSHLLSGRLV
EFLHQTHLKYGAVVRVAPNEVIFTSSQAWNDIYNVRQGAPEMGKDTPLYQSLGTPPTIAEAGHDLHRRYRRLLAKGFSEA
GLREQEPVIQQKISVLIKQLHAATAKGTTPEMTSWFNFFTFDLISELTFGESFKCLENGRFHPWILMVTQSIKFRAIIQA
LGYYPLLFKLFMGLIPKSYQEAFRDHQKLTSENVQRRIDKKVDYTDLASNLIDPKHNLERYEIDGNCAVLIVAGSETTTT
ALSATMYYLTQNPEAKAKVIKEVRSSFSSAEEITAISVNQLKYLPACFNEAMRKLPPAPAVFTRRVPREGAYIAGNWIPG
GTHVGMCHFATNNSSLNFKDPEKYTPERWLGDPEYEDDARAAMQVFSVGPRNCIGQNLARLELRLLLSRVIWEFDWELDP
VSVDWDKDMPVYLSWGMKPLKFHFTPVVR*
>CYP65AC3P Aspergillus nidulans 67% to
CYP65AC1 AN10101.3 (partial)
ETYGPILRIAPGEVLFTSSSAWDDIYGARPGKPEMDKXXXXX
KGPIAPHSIVAVDGELHRFLRRLLAREFSDVKLREQEPVNQRSINLLIEKLHDEVAAGKTPEMTAMFN
YATFDLIGELAFGETYGX
MENWRYHPWVKMIFYVMKLRALTHAVGYCSWVFPILXXXX
PQVLRD*FVVHRKYTTYDKVQRRKDRKIHYWELTTNLFDPQTGLER
XXXXXXXXXXXXXXXXXX
STALSATLYFLTQNEDAKRKVIGEXXXXXXXX
GDIKSISVTQX
KYLHTRVNETLQIFPPRSAVFPRRVPLGGDWILGGTKVGSVHCCISCCRWNFV
DPDKFIPERWLSAPAY*NDDRRAMQAFKSSSLHFS*SLRLKMRLVLARLICEFDLELA
PGSE*WEGALVFNVWGTKPFKI
>CYP65AD1 Aspergillus oryzae
GenEMBL BAE55230.1
45% to 65V1,
43% to CYP65AF1
revised
3/17/2009
MLPANNLAFILSPVVTFELIGGVIAL (0)
VSIAAIASWSYNVFFHPLSNYPGPRLAAATRLWYAWHCAKGSLPFAIHELHLRYGDVVRVAPDELSYIHP
DGWNEIYGHRPGQSEIPKDPSFYSSALSSPEGIFRAPRDRHGYIRRQMSHGFS
EKSMREQEDTIRHYADLMISYLSTQANGPKENVVDFTRWYNYFTFDVMGQLVFGESFNCLQSSGFHPWVS
IIFDSIRYNVFVRCTQFWPWLSPVIRRFIPKSFQRRKIEQQALSREKANYRKTIHDGRNDLVANLLKPDS
GVTDLEYQSTVQTLIVAGSETTASLLCGVTFHLLNNPEKLEKAVKEVRSEFDSADKISFVSVNKLHYLLA
CLNEALRVYPPVADGFPRRTGSNVEVINGQPVPPNTAIRMTHWATYRSPRNFVRPNEYLPER
WLGNAPGFEKDHKNALQPFHVGPRNCIGR
NLAYMEMRLLLALVLWNFDLELYPA SKLWDKQRVYNLWEKPELKVKVLPRKI
>CYP65AD1 Aspergillus flavus
AFL2G_00138
MLPANNLAFILSPVVTFELIGEVIAL (0)
VSIAAIASWSYNVFFHPLSNYPGPRLAAATRLWYAWHCAKGSLPFAIHKLHLRYGDVVRVAPDELSYIHP
DGWNEIYGHRPGQSEIPKDPSFYSS ALSSPE
GIFRAPRDRHGYIRRQMSHGFSEKSMREQEDTIRHYAD LMISYLSTQANGPKENVVDFT
RWYNYFTFDVMGQLVFGESFN
CLQSSGFHPWVSIIFDSIRYNVFVRCTQFWPWLSPVIRRFIPKSFQRRKIEQQALSREKANYRKTIHDGRNDLVANLLKP
DSGVTDLEYQSTVQTLIVAGSETTASLLCGVTFHLLNNPEKLEKAVKEVRSEFDSADKISFVSVNKLHYLLACLNEALRV
YPPVADGFPRRTGSNVEVINGQPVPPN TAIRMTHWATYRSPRNFVRPNEYLPER
WLGNAPGFEKDHKNALQPFHVGPRNCIGRN (2)
LAYMEMRLLLALVLWNFDLELYPASKLWDKQRVYNLWEKPELKVKVLPRKI
>CYP65AD2 Aspergillus terreus
AAJN01000140.1
60% to CYP65AD1 Aspergillus flavus
ATEG_04967.1
MAISHLLTPDMTDFSLVTALGTVIAL (0)
29486 (0)
GVLWTIGSAVYNVYLHPLSRYPGPRLAAASRLWFCWHLIRGELPFVIHELHLKYGDIVRVAPDE 29295
29294
LSYTHPDAWNQIYGLRPGKREIMKDPTFYSS
29202
LPSGKGSIVNAVRERHGHLRKLMSYGFSERALREQESVVRFYADFFHQRDHGDIG
&
GKGVRWIWVRWYN (0)
FFTFDVMGHLVFGESFDCLQSTG
YNPWVALIFDSVRIGGLLRSIKFWPWLTPIVQHLVPAKLQERRKEQKRIARQKAAYRKSI
EDGRRDLISSLLQPDSGVTDAEYQSTVESLIIAGSETTATLLAGVTFHLLKNPDKSKRAT
MEVRNAFSSPEEITFVNVNKLPYLIACLTEALRIYPPVGDGFPRNTGENTEVILDERVPPN
()
TLVRVTHWATFHSPSNFARPDEFIPERWLEGEHGFENDRKSAL
QPFHVGPRNCIGRN (2)
LAYMEMRLLMALVLFRFDMELCDVSEDWDK
QKSFLLWAKPELMVRLSPRTV*
>CYP65AE1 Aspergillus oryzae
GenEMBL
BAE60010.1
40% to
CYP65AF1, 39% to 65S2
MEALPTYLESFWHSGGGTMGISILVMLSTFLALGTIFVYRIWLHPLSGFPGPKCCSVSSIPVAWAQLRGR
NHEFVSSLHRKYGSVVRISPSELSFISGAAWNDIYSRSKGRPALERDRTFFNDMLVDPETITMANEATHS
RIRRAMAPAFSPRALLEQEPIIQANIKLLMDKLEARAGSGGAPTDLRAWFNYTTFDLIGDLAFGESFGCL
ATSTCHEWVQFVLDHFYTSTLLHVVHRFHPFNRVLAALLPKSLIEKRKAHDSMTLTKVHRRLEVQGRRND
FTQHLLDAAEAGTLSSREVEKQASVLILAGSETTSVALTFAIYLVLTNKPVLDQLNDELHSTFKEEQEIN
LLSVNQLKYLHAVIQEALRFCPPISNGFPRQTPPQGATVDGMFIPGKTVVNINHWAAYRSPRNFTLPEQF
LPERWLGDPRFDEDAKDVFQPFSVGPRNCIGKKFAYDSMKLILAKFLWRFKPTLLDKSRSWLAHQPTFVS
FHQPPLLVDLEIKGSDAFPVRE
>CYP65AF1 Aspergillus oryzae RIB40
BAE65144.1, AP007171
CDS
join(1760697..1760719,1761316..1762453,1762525..1762691,
1762742..1762901)
MLSFLPLPGPFSSPVGTVGFYLGLGVLL (0)
SILYLFAVIIYNVYFHPLAKFPGPKSYAATRIPYFQALLGGQIGQAIKDLHQK
YGEVVRIAPNELSFIDGEAWKAIYGTRPGHKQKPKDVRYYPPTAGGVPSIVISNDEDHSRFRRTLSHAFS
ETSLRVQEPLVNSYIDLLIQRLHEHCEAGNKPLDMVAWYNFTTFDIIGDLAFGEPFNCLQNSAYHKWVSM
IFSNIRYGTYGNLARRFPGSKFLLRLITPTRIANGRNWHIELTKEKVKDRLAKSNDRMDFYGHILKQKDT
ERAMTFDEMVTNGSTLIVAGSETTATLLSAVTFYLLKNERVLSKLQQEIRASFESEKDITVTGCNQLEYL
NAVLTEGLRIFPPTPTGLPRIVDADGDMIAGKWVPGGTIVSIPHLAAFHSASNFTEPESFIPERFLGDPR
FANDSKTVLQPFSFGPRNCIGRNLANAEMRLILARVLYNFDLELDERSENWSRQETYILWNKPGLY
VRLRPRVGI
>CYP65AF1 Aspergillus flavus
98% to CYP65AF1 Aspergillus oryzae
AFL2G_05426
MLSFLPLSGPFSSPVGTVGFYLGLGVLL (0)
SILYLFAVIIYNIYFHPLAKFPSPKSYAATRIPYFQALLGGQIGQA
IKDLHQKYGEVVRIAPNELSFIDG
EAWKAIYGTRPGHKQKPKDVRYYPPTAGGVPSIVISNDEDHSRFRRTLSHAFSETSLRVQEPLVNSYIDLLIQRLHEHCE
AGNKPLDMVAWYNFTTFDIIGDLAFGEPFNCLHNSAYHKWVSMIFSNIRYGTYGNLARRFPGSKFLLRLITPTRIANGRN
WHIELTKEKAKGRLAKSNDRMDFYGHILKQKDTERAMTFDEMVTNGSTLIVAGSETTATLLSAVTFYLLKNERVLSKLQQ
EIRASFESEKDITVTGCNQLEYLNAVLTEGLRIFPPTPTGLPRIVDADGDMIAGKWVPGGTIVSIPHLAAFHSASNFTEP
ESFIPERFLGDPRFANDSKTVLQPFSFGPRNCIGRNLANAEMRLILARVLYNFDLELDERSENWSRQETYILWNKPGLY
VRLRPRVGI*
>CYP65AG1 Aspergillus oryzae
GenEMBL
BAE60004.1
45% to
CYP65AF1, 39% to 65U1, 47% to 655Z1
MSRRFPIQVAQSEIPPIAWGLWRMVYRLWLHPLSGYPGPRLAAVSNLPYFAWTCTGNLHLRLQELHKVYG
DVIRIRPNALTYRTPEAWTDIYGHRKPGTLPFSKDPEFFMPAQAGSSHMINANEKDHTRQKRLLNHAFSE
RSLRQQEHLIMGYIDLFIQRLRGQARMGAETVNMEEWLNFLTFDIIGDLAFGEPFGCLQNSEYHPWVATI
FKSIKTGAILRALNIYPILLGFIRRFLPKSLVQKRIAHYQMSKDRVTRRLQTETSRPDFISYILKYNDDR
GMSTPEIEMNAALLIQAGSETTATVLAACLYFLQKNAACHRRLVQDIRSAFTQETDINFLSAAQLPYMNG
VIEESLRLFPPAPGIGPRVVPKGGARICGRYVPGGVSVSVGHYSTFRSARNFTRPNEFLPQRWLDRDAES
EFASDQTMALQPFSYGPRACIGRNLAYAEMRTILAKILWHFDVQLDERSADWANSKSYIVWEKGPLWLKL
HPRNVPQETD
>CYP65AG2 Aspergillus niger
e_gw1.3.1457.1|Aspni1
57% to CYP65AG1
MDGPIPKLLVSVSRTLIFKYARPLHHPQSSSQLPIASPGPNRILEKVIIVTIFRYFYRLFLHPLRSYPGPRLAAISHLPY
ISWCVRGILHSKIRTLHEQYGEVVRIRPNSLTYCAPQAWEEIYGHRKKGQRTFTKDPQFYIASSGQFTSMINANEEDHIR
QKRLLTHAFSEKALRDQESLIMAYIDVFITRLAEYAASESPRATNIVHWLNYLTFDIVGDLSFGEPFGCLDRSTYHPWVE
TIFKSIKTGAFLRALAIYPLANIAFNKLKPKRLIRKRLEHYQLSRDRVHKRLHVSNTISRPDFLKYILKNNSFQEGAGMA
VAEIELNAALLIQAGSETVATALSACCFYLGRNPPKLEATVREVRTTFADSGHISFSATSALLYLNAVIKEALRLYPPAP
GIGPRLVPEGGAVINDQFVPAGVSVSVAQFSTFRSPASFIEPDSFLPERWLPNSDSRYLTDNKNALQPFSYGPRACIGKN
LAYAEMRTILSKILWHFDISLQPGSDSWDQSLSYIVWENQPLNVVLRPAMNS
>CYP65AG3 Aspergillus terreus
64% to CYP65AG1
ATEG_08791.1
MAGWNILLTTAIAGLVCRIVYRVLLHPLSKYPGPKLAAISNLPYTKWSVTGQLHSRIRELHERHGDVVRIRPNSLTFSDP
QAWTDIYGHRKAGAPPFRKDPEFYIPSSNGSTNLINSSEADHARQKRLLTHAFSERSLRDQESLVMAYIDLFITRLGELA
NNSQDVDLLHWLNYLTFDIVGDLAFGEPFGCLKDSAYHPWVAILFQSIKTGALLRALTIYPTLAKIIRYFMPKSLLRKRA
DHYRLSKEMVTRRLDMDTTRPDFISYILKYNDERGMSRSEIEVNAALLIAAGSETTATTLSACVYYLQKNPECYKALTEE
VRQAFSKDEEITFLAAGKLPYLNAIIEESLRMYPPAPAIGPRLVPEGGAVVNGEHIPGG (0)
VSVSVAHYPTFRSSSNFAEPDSFLPERWLRDNEDSRFRNDKREALQPFSYGPRACIGRN
(2)
LAYAEMRTILSKLIWHFDITLDPRTTDWDNARSYIVWENKPLWVRLTPTSAHLSSK*
>CYP65AH1 Gibberella moniliformis (also Fusarium verticillioides)
AF155773.4
fumonisin
biosynthetic gene cluster,
FUM2
47% to 65L1,
45% to CYP65R1
also Fusarium verticillioides FVEG_00323
MYQITAICDARWWLCLAFTCMAMLALFSFGVVMYNIFFHRASKF
PGPTIAGATSFRYHWAMSTGNVAPWLREQHARYGEVVRIAPDMISYVSPDAWKDIYAY
KPGEKEQNGIDWTIPSRDDDVPSMFSEPNDAEHNRVRRLFLPAFSDRALKQQEPLLSK
YSDQLVHLIRRGIDDNRDQEFDAVKLYNFTTFDIMGDLTFGEPLGLLKNSSYSEWVQN
LFRDIKTAGIFLFIFDFPPLPWLVKKFSPPSIQRAHEIHKQHTVDRVNRRLEKGLDRP
DIWNLVLSQPEGRGLTHPQMHANADIFMIAGTETTATLLSGLTYLLLKNPEKLQRLVE
EIRGSFGSIEELTVENLARLPYLSACLSEGLRCYPPVPIGPSRVTPKTGGQVLGERVP
GRVRLTIPQCAAYYSDLNFKDPYSFIPERWLPGTGYESDRKGILQPFLIGPRNCIGQN
LAYHEMRLILCKLLWHYDIELCPDKGNWLLDQKMYIFWEKRPLMVKFTKARK
>CYP65AJ1 Alternaria solani
Alt1 BAD83680 48% to 65J1 Mg
PKS for alternapyrone is next to three P450s
called alt1, 2, 3
Chem Biol. 2005 Dec;12(12):1301-9.
1 mpaaselerr tkrsksrnki
skpianmlsv iafsicispi vyflirsiyy lvfhplsdyp
61 gpklwaisri pwnyvnlqgd
lawrirdmhl hynssviria pdelsytsst alkkidgtpp
121 preflkcldg rgiapavvnr rrsivtetpe
rhtilrralq pafseralrd qedffrdhtd
181 rliaqlrkpq ygvteqnilr wfallsfdim
sdlafgqpag cldlvdepwl gvigsrvksi
241 vwyqfavyyr iewilkwimp kaamearkrh
qaltlqkvqr rieeersgkr egkkrdfmsy
301 ilgndkenls nmdlfgmasa fivagsnttt
ytmtaftffv crdsevyakv iaevrdkfas
361 dtditmvaag dlpylkacie etmrlspptp
salprwvleg geeidgkwvp ggvtvgvhnl
421 aachvpwnwh rplefiperw lqtkegefth
ddralharfl mvdimsltcf lssmamnemr
481 lalaklfwnf dislsrnsgn wwitqksylv
wekkplmvti kprh
>CYP65AK1 Aspergillus niger
fgenesh1_pg.C_scaffold_9000016|Aspni1
42% to CYP65R1, 34% to fgenesh1_pg.C_scaffold_5000711
MIHENLHEALQGRYLILTAGLLFFSLVGKCFYELYINPLCKIAGPKLAAVTRLVYMYHNLMGDEHTWMRNLHLVYGDTVR
ISPDQVSYSSAEAWRDIYGHASATKKSTEKDKRFFGTTLNGTPDVIRAPAADHSRFRRNFSHAFSDKALREQQPLIAHYA
DMLIDKLREIVQADPKARIEMVMMYNLTTFDIMGDLTFGDPLNLLKGTGNVAWVTSIFSSVKINSLRRIARYYPWCSYFL
NSLLPRSLKQRQASHYQSCKDRVDWRVDQSLDRPDIWGLVMAQKESLRLSREEMYANSQLFMVAGTETTATALSGLTYQL
LLNPDKLEKITNEVRDAFEQSSDIDMLRLAQLKYLNMCIDEGLRMYPPVPTGMPRLTPKEGMEICGEYIPGDTAVSVHHW
ATYRNPRNFTRPDEFLPERWGNDPQFASDNKAACQPFSFGPRNCLGKNLAYHEMRLILAKVLYHYDLRLAPESVGWEKQN
TWTLWQKNRLMVQLTPRA*
>CYP65AK2 Aspergillus terreus
68%
to CYP65AK1 Aspergillus niger
ATEG_04213.1
MFVEALSQVSFEHLPHIVLGTVCVPIPPVHGLQLTSVHSLQLVFAAIAKITYELLINPLRKYPGPKLASVTRAPYIYHTI
KGDLVQWIHNLHTVYGDVVRTAPDELSYATGDAWKGIYGHASAGKKATEKDMRFYGPSFNDTPDIIRASGPDHARFRRNF
SNAFSDRALREQQSLICRYVDMLIEKIKVEIEIDPLAKVEMVRLYNLTTFDIMGDLTFGDPLDLLKGTGNTGWVSSVFSS
VKRGAFRRASRYYPWAALLVKLSVPRSVIEKAANHFRACVERVDWRVNQKLDKPDIWGLVLDQKENLRLTRAEMHANSQV
FMLAGTETTATALSGLTYQLLLNPDKLERITKEVRDTFKQDSDIDITTLAQMKYLNACIEEGLRMYPPVPAGLPRLTPPE
GMVICGEYVPGKTAVSVAQWATYRNPKNFKRADEFLPERWTDPSFSTDDKSAFQPFSFGPRNCLGKNLAYHEMRLILAKV
LYNFDLVVAPELVGWDKQKSFTIWEKNDLMVQLKPRD
>CYP65AL1 Aspergillus niger
fgenesh1_pg.C_scaffold_5000711|Aspni1
42% to CYP65Z2, 43% to CYP65Z3
MEVGLFQTMVANANGLILAVLVSLGCWVIYTLYFHPLARIPGPKWWIISRIPYFRSITTGQFIHSVRALHERYGPVVRLA
ANEVSFTDPQAWQDIYGHHGGERAFPRNPVWYQPALNGVHHILSASNSDHARIRHLLSHAFSERALKSQEPMIQVFFNLL
IERLRPLADGRQAININDWLQYTTFDITGELEFGESFGCLEKGEYHPWIKVLLSNFRKIILFGASQLIPGLRFLVGLTIP
KAVMQQRQQHFSYTVEKVSRRLARGNDPMRPDFLTYINRYNEDEKKGMSRAEIDSTFNVLVIAGSETTSTCMTATLHCLL
RNPATLQRLQTEIRSTFAHDSDITFDSTIPLPYLNAVIEESLRLCPPAPTMLPRVTPAAGAYVCGYWLPGGTAVEISQYA
MSRSHANYGDPDRFIPERWLVDEKPNLHPHDARAHRPFSFGPRNCLGRSLAWMEIRCVLCKLLWNFNLRMESPDYEWNEQ
GTYVMWDKKQMLISLTPVKR*
>CYP65AM1 Aspergillus niger
estExt_Genewise1.C_31719|Aspni1
45% to CYP65AF1, top 28 hits are CYP65 or CYP60
MAINTLVMDVAMRVEWLATPRVILGIGAGWLFIYIISKVVYALCLDPLRHIPGPRLNAVSMIPYARHLLAGTTVQNSVSL
HQQYGEVVRIAPNEVSLICGETAFPDIYGFRTGKMKGHLNMSKDPVWYVTPSNGAPSILQANDEDHSRGRRVLAHAFSDK
ALMGQEPLVQRYVDQLIDRLKEVTSANDEPVDMVKWYNWTTFDVIADLLFGEPFGCLQDLSTHQYVALLFQSLKSLRMIY
ILAYYPWLRFLGNLIVDKGLIQKRKEYATWVSTQVTKRINTATPRPDFMSHILANNNNRGVKLTRAEIDSNATLMTTAGS
ETTATLLSGATYLLLTHPRVLRTLQDEIHSEFPTYESITLEAVAKRTPYLNAVISEALRFFPPIPVGFIRRVPKGGETVS
GYWIPEGTILSVSHYAAYHSERNFRDPDSWVPERWLGDERYVNDKRAAFQPFSFGPRSCLGRNLAYAEMRLILAKMVWSF
EMELDEGLSRDWLQRCRVMRLWQKPELEVRVRPR
>CYP65AM2 Mgr059 Mycosphaerella graminicola
65% to CYP65AM1 A. niger
MDSLRDRLAGKPWTIVGLLVALAAAYFVVTAIQHVLFSPLKHIPGPRINALSRIPYIRHMLAGTTAKMTVDLHKQYGEVVRISPDEVSFISGETAWGDIYGFRTGKLKGHLNTQKDPAWFPPPVNGAPSILLAKDEQHSKGRRLLSNAFSEKALTEQEPLVNRYVDQLVDGLRDTIRTEKKPVDMAQWYNWTTFDIIADLLFGEPFGCLQNKETHKYIAMLLEGLKAIHFTYIFRKFPLAKHFMGLLVDKKTIPSPNVRVNYQKWISSQVQKRIDRETQRPDFMSHILANNGEKGYEMSRAELDSNAQLFINAGSETTATLLSGATYALCRNPRVLEKLKKEVRGRWNNYHDINVAEVSKAPYLAAVISEALRYFPPVPAGFNRKIPEGGEVVSGYYLPGGTSTTISQYAAYHSEMNFKDPDAFIPERWLDDPKYANDKRSACQPFSFGPRNCLGKNLAYAELRLIVAKMIWTFDMELDAASNDWLERCQVFTLWWKPALLVKLTEAVRD
>CYP65AM3 Aspergillus clavatus
92% t0 65AM1
ACLA_077670
MAIGTLVMDIAMRAERLATPRAILGIAAGLTFIYLLSKVIYALCLDPLRHIPGPRFNAVSMIPYARHLLAGTTVQNSVSL
HRRYGDVVRISPNEVSLICGETAFPDIYGFRTGKMKGHLNMAKDPVWYVTPSNGAPSILQANDEDHSRGRRVLAHAFSDK
ALMGQEPLVQRYVNQLIDRLKEVTSANDEPVDMVKWYNWTTFDVIADLLFGEPFGCLQDLSTHRYVALLFESLKSLRMIY
ILAYYPWLRFLGNLIVDKGLIQKRKEYATWVSTQVTKRINTATPRPDFMSHILANNDTRGVKLTRAEIDSNATLMTTAGS
ETTATLLSGATYLLLTHPRVLRTLQHEIRSEFPTYESITLEAVAKRTPYLNAVIAEALRFFPPVPVGFIRRVPAGGEMVS
GYWMPEGTVVSVSHYAAYHSERNFGDAESWVPERWLGDERYVHDKRAAFQPFSFGPRSCLGRNLAYAEMRLILAKMVWSF
EMELAEGSRQDWLQRCRVMRLWQKPELEVRVRARVVA*
>CYP65AM4 Mycosphaerella fijiensis
62% to CYP65AM2 Mycosphaerella graminicola
estExt_fgenesh1_pm.C_10205
MDTSSAERPISFTAGFATLALLYVVGNLIYKLYFGPLSHIPGPKLNALSRLPYIRHLLKGTTVQNVNELHEKYGEVVRIS
PNEISFTSIDTAWPDIYGFRTGKMKGHLNTLKDPAWYPPPMNGAPSIIIADDDLHSKGRRVLSHAFSEKALTDQEGLLQG
YVDQLVDGLRETIKTKPVADLTKWYNWTTFDIIADLMFGEPFGCLQTGETHWVITLLFDSVKAFRMFYISRYWPWVKSLG
SMIIDKRLIAKRTVYFAWVSKQVKNRMERDTQRPDFMTLILQHNGEKGYKMEKGELDSNANLMLTAGSETTASLLSGATY
CLLTNPAVLQKLTEEVRGKWASYDEITLHEVNSSPYLVAVMNEALRYFPPVPTGFERRIGPGGETVSGYYIPEGTSVCVS
QYPAYHSEKNFKNAEQFVPERWMGDEEYKDDKRSGMQPFSFGPRNCLGKNLAYAEMRLIMAKMVWSFDMELELQSRDWIQ
RCRVHTLWDKPALMVRVTEAVR*
>CYP65AN1 Aspergillus niger
gw1.16.109.1|Aspni1
36% to CYP65Z1 top 26 hits are to CYP65 or CYP60
YSILCVFYNIFFHPLKHYPGPRIMASSRLPIFFLVLIGRSVNILEKLHAKYGPVVRVAPDELSYTAASAWKDIYSSSAAW
PLAIPRNMVFFRAMAGEYGFHSLVTANNQDHARLRRLYSRAFSKQALAAQEPLIIQHIDNLIKKLYAEIDHTAKPVDINL
YLNLALFDMINDLQFGEPLNLLDDTTHRAFARASLIIVPSAAVIQALADFPLARIILKPILRELFRMRRLYFSTTDERLE
KRLASNSYRADIVQFLTDAKSDNISLQEIQANAPLMNIAGSGTSAVALSGLIAHLLLAPHILKDLQSEIRSKFHTTSNIT
MKNMVDMPLLDACIKEVLRVFPAVPVTPGRLVPSPGVTIAGKWVAGGTRVYVTPLAAFHSTDNFHDPETFAPQRWYNTKE
ESSFTCKDVKGAYKPFSVGPYNCIGQYMAHYVVSLFICNLLLHFDLEIATDPKTWLSNQRAWIIWHNPPLNV
>CYP65AP1 Aspergillus niger
gw1.10.1058.1|Aspni1
40% to CYP65AF1, 60% to fgenesh1_pg.C_scaffold_1001144
Top 27 hits are CYP65 or CYP60 (CYP5118 also in this set,
may need name change = 41% to CYP65Z2)
FPILLALKRLYFHPLSRYNGPLLWALTRVPYMLAFRNGQLAHKIKAFHEVYGETVRVAPNEVSFINPDTVKDIYQRRPSG
GGFKSLPKDPIRQAPPRPGQPISILDAGDADHTRLRKAYAAAFSSQALSAQEPLVASYVDKMITQMQCQSKLIAQSVDLQ
EWISFCTFDIVCKLSFGEDFGCLDNQRYHEWVGQLVHSLKAKVQLASCRFYPWLFNYLVKRLPKSAGILMAQHQATTKEK
VKRRLQQLESDAKSSGAAGVIRPDFLAHLVQQSRQEISEGEMVVNAATLIVAGSHTLQTAITGILFHLLQNPTVLNRVTS
EVRGEFPSTSQINVSTLLRLPMLEAAIKEGIRLTSPVPLGLTRLVPIGGHTINGEYFPEGTVVSYMQWAANVSPQNYTDP
QAFHLERWLKSRQPSSSSRDDFFEKDQRHATQPFLQGPRDCIGQNLARMEIVLILGKLLYHFDLQPEGGLGHWEDQETYA
VWVKTPLPVKLRVRQTD
>CYP65AP2 Aspergillus niger
fgenesh1_pg.C_scaffold_1001144|Aspni1
40% to CYP65Z2, 60% to gw1.10.1058.1
MLAFRSGRLAHDIKRFHDIYGDTVRVGPDEVSFLDPDCIKDIYSRRPNNPHYKALPKDPIRQKPPQPGQPGDILDVEDDD
HSRIRKAYAPAFSTQALNAQKPLVTSYVCKMVAQLKSRANSTDPSRRIVDLQRWVTYCTFDIICSLSFGEDFGCLDNDSY
HEWVGMVVNSVKGKVRIAAFRFYPWLFNYLVKSLPKSAQLMVKRHQAMTNEKVQKRLHTAVDRPDFFSYRLKSKNELTEP
EMEINAATFIFAGSHTLQSSLTGILFHLLKNPEALARVAEEVRSSFPDEGDLDANKLSKLPLLDAAIKEGIRLTAPVPLG
IPRLVPRGGHTVCGQYFPEGSKVAYNSWAAGVSPRNFADPTKFHLERWLNPDEGRFANDRRSAVQPFLQGPRDCIGQNLA
RLEMSLVIGYLIYHFDFVLPNGREALGEWEDQETYAVWMKSPLMVELVAR*
>CYP65AP3 Histoplasma capsulatum G217B
ABBT01000035.1 Ajellomyces capsulatus G217B
68% TO CYP65AP1
HCB00649.1
MTVNALFTAVTTALLLPILIALKTL
32798
YFHPLSRYNGPTLWAITRLPYMLAFRSGKLAHKVKHFHEVYGDTVRVAPNEVSFI
NPSCVKDIYNRRPSSEFKSLPKDPIRQPPPQPGQPISILEAGDEDHARIRKSYASLFSSKALAAQEPLVSSYVHKMISQL
KLQTGESNTTVVDLQTWVSYCTFDIICSLS FGEDFGCLENNRYHEWVGMLVHSLKGKVQLAACRFYPWLFRLLLKRIPKS
AMSLMAKHQATTREKVDRRL
SSTVDRPDFLSHLQNSKHQLSHAEIVTNSTTFVFAGSHTLQTAITGILFHLLHNPESLAK
VTEEVRASFATTEDIEFRNLSKLPLLDAAITEGIRLSSPVPLGLTRLVPEGGHTINGEFFPAGTIVSYMQWAANLSASNF
ADPTSFLLDRWL HTDRDLFAN
DRRDAVQPFLQGPRDCIGQNLARMEISLILAHLLYQFNLSPPTGAGHAGVQRWEDQETY
AVWVKSPLPVRLSVR 34272
>CYP65AP4P Aspergillus terreus
some parts are 76% to CYP65AP1 Aspergillus
niger
ATEG_04921.1
LYFHPPSRYNGPLLWALTRVFYMLAFRSGQLAHKIKQFYEQYGD
TVRVPNEVSFINSDCVSDIYS
LVTGHVGKTIVQLKTRAAAATPVDLQRWISYCTFDVICSLS
FGEDFGCLEHNRYHEWVGVQVYSLNAKVQLAACRFYRWLFRLLVRSMLASAQVAMAKHQA
&
PVFNAAI
KEGIRLTSLVLLGLTRRAPSGGAIFCGAYFPEGTVVSYMQWAANVSAKNFTDPTEFTLERWLPPVGPRYQHDRTDATQPF
LQGPRDCLGQNLAKMEMALTVGRLLYEFDLSVPAG &
WEEQETYTVWVKSPLGVQMKGVVM*
>CYP65AQ1 Aspergillus niger
gw1.10.1062.1|Aspni1
37% to CYP65Z2 top 36 hits are CYP65 or CYP5118A1 (needs name
change)
PTTLVIYNLFLHPLARYPGPTLWRAFRFPFLLANIGGQLPHRIHDFHAQYGDIVRVAPDELSFVDPRAWRDIYTSDREFV
RPHQYKDQPPGKTAANLIACSEAEHARLRKNLAPGFSEKFAALQEPILQKYIDTLFAKLDAKIASSEGDSASKGADVDLV
EWINYLAFDVIGDLTWGSSFGCLEGLRYHPWVQTVSQFKAAIVVGMIKFYPPLYRLLMAITPADALKPVMEMWKVTDERV
AERVATTAPSTTTRPDFVGIMMASGAMTQEEMEVNSMLIIAAGSESITTVITGVINYLLREQDQRSLRELVNLLHNTFPT
EEKITATRLKSVSYLDAVLMEGMRLCPTIPDAMRRQVPRGGAKVAGQFVPEGMIVSIPPLASYRAPGNFSSPTEFVPRRW
LGEDKQFDLSKQKKAFNPFSLGSHNCPGQNLAWIELRLILARLLWRYDLAAVDVPAWEKQGIWWFWDKKPLVVRIK
>CYP65AR1 Aspergillus niger
gw1.11.201.1|Aspni1
36% to CYP65AH1, top 21 hits are CYP65
MVTYNLFIHPLKEVPGPRMLAASRIPVTYASLKGIQTQWLHNLHLKYGPVLRVAPNELSFIDPQAWKDIYSSSPTEPQSM
RRGSDFFRYLEDDDNRPSILAANEIDHPRIRRAYVPAFSRRALARQESILAKYGDALVERLSGIEGQITNIRNMFHYTLF
DIVGHLHFGEELGVLRTGAHKSWVHSQHRLVRAATLLSALAEFSWINLLFRSTIPWMSKWLRKAYFKPSNDLIDRRLQLQ
SDEPDLIGLAFRNSRSLSLTEKDIRANAHIMMTGGAETTTALMTALTAYLLQHPECLARLKNDIRTAFHDKSQVSLESVS
NLAYLDACIKEALRLYPSVPGALHRATPAGGARIAGRWVSGNTRVYIPIFAATHSPTHFWSPDKFIPDRWLDGADDPYQK
DNKTAFHPFSTGPRGCIGQDMAYAMTKIVFCKFVTEFDCELAVNESSPWLAGHRSWTTWEVPPLMVRVSRCK
>CYP65AS1 Mgr044 Mycosphaerella graminicola
39% to CYP65E1, all top hits except CYP5117A1 are CYP65
sequences.
This may mean that CYP5117 should be renamed.
N-term from JGI model
estExt_Genewise1Plus.C_chr_11525|Mycgr3
MLDWMSVAPSGLSAFAGTVLLAL
IYSATTVGYNLYLHPLAKYPGPKVRAASGWPYFLDLIRGNSPQYMLELHDQYGPVVRVAPNELIFNRPQAFKDIYGRKAG
QKELRKDEMYASGMGEPTLLYCDETYHSYIRKLMAPGFSESALRKQETVVQSRLALLICKLHEEGQDGHASIDLMKWVNF
FIFDVVGHLTYGDSFECITSSALHPWITKFTGLGRPMAYAQASQRLPRFLRLPFLALMLDRSLLSDRKFLYKTSEAKVQA
RIAKESPIPDFMGTLIESHKDGKMTALQLNSNAVFLMAAGTETLVTSVVHTIFRLLTNKHALLKLTQEIRSTFTTSEDIT
MTGVNKCRYLLACLDESLRIQAPSPVTHPRFTPTEGITIDGHFVPGNMAVGVPIHAACRSSVNFHDPDTYAPERWTGEDR
RYINDSKDAAMIFSVGPRDCLGRSIAMIGLKLVIARLIWHFDIEQCFPDDWAEQKVYLVWEKSPLMVKLHPVK
>CYP65AT1 New seq
e_gw1.3.1373.1|Mycgr3 Mycosphaerella graminicola
40% to 65L1, 41% TO 65Z2
MSPYLILAVITATYLGFKIVRSLHDAYFGPLSKFPGPKLRALSKWPSNITVIRGSEGVELPALHEQYGPVVRIGPKELSY
AGGAASWRGIYGWANNPRSCPMYADFRRTKPLNRVDGIFTADDANHGRQRKILSHSFADKTLKDFEPMLKLWVGKLTDRI
ADKSGEEVDLLQYYNCTTFDIMGDLTFGEDLHMLETGEYNDWVKAIFQGIKSGTIIRGVKHLSAISEWVVNRFVVYNPKV
RTATAAPSFANVCSLYSERRDLWTKILAKSNTPEALTYDEHHSNAAIFMVAGTETTAAALAGTTYWLLRNPDCLNKLTSE
IRDAFANAAEITLDSVQRLQYLQAVLQEGLRMYPPVPSKLPREVPAGGTMIDGELIPEHTSVGVHQLSTYRLESNFKDAY
EFHPERWLGDERYANDHLDALEAFSVGPRSCIGKNLAWHEMRLILTNILFHFDLQLSKESIDWHDQKIYTIWEKRPLLVR
AVPRSS*
>CYP65AU1 Coccidioides immitis
47% to CYP65X1
CIMG_09823.2 revised
MELLSSILLFLGLAAVLGVLKIGYNVIYNLWLSPLAQFPGPKLWAISAIPSQLSIVRGTIHFDITALHERYGPVVRIRPN
ELAFNTAQGFKDIYGFRPGGCFPKDRSRYMTPINGADHLVSAIDDGVHARHRKLLSYAFSNRALREQENVIRGFTDTMITKVRGEVHAGRPTVDMKNWLNYTTFDITG
DLMFGESFNCLRDTK
LHPWIAMIFDSMKALAIMGAAGQFPLVQPWLDKLIPAYLKKQEFDHFNLSAGKADRRLESGVSPRGDFMSAFIQNGFVEK
QEQFYEGKKILRRDEIHSNSFILMLAGSETSATLLAGCIYFLCKSPETMQKLSDEVRSAFTSDSDITFDKAATLPYLGAV
LEEAMRCYPPVAAFLARVVPPGGASVDGYFIPENTIVACHHYASYHSSSNFSRPNDFIPERWLGDPRFESDKRDAMQAFS
LGPRNCIGKNMAYAEMRMILCKLLYHFDMELTPETTDWTNQKVYFLWAKKPLMVTMKDRLSSDY
>CYP65AV1 Histoplasma capsulatum
39% to CYP65AZ2, 40% TO CYP65AF1
HCB02537.1
MGFVDSYITLTIFGVGLLLYVVGNAIYNIYFHPLSKFPGPKYLAVGRIPITLATLRGQKAQFRFNAHRKYGEIVRIASNE
LSFAHAQGWRDIYGTQAKLQMAKPASGIEEQEGAQSVVTAEGDTHVRQKRMLATMFTERMMKEKESLFISHADLLVKRLA
MLEGQPVALGDWYNFTTFDMMSDLLFGESLGMLSNSEYVPWVRSIHGFLKAFAFITVLNEYLWFRVLWAFFPSKILNTLR
ETHFLFTSQKVEHYLQLDEKTRAGMMGHLLDGGSRKGLNLGELHTNAPILIFGGSETSATQLRSLSFLLFKNPEKLGKLI
SEIRSAYTSSDRITYDSLLEHTYLNACIEEGLRYYPPCSNGLPRVVPKGGTTICGEFVPGGTNVSVATYALFRSPKYFTQ
PDSFIPERWLRESEGGSPVFATDQKGIALPFSYGPHNCPGKKMGYFELRLILAKVLWHFNLELLPEADGAEDSWDNMQNY
QTWSRRPLKVSAKPVRR
>CYP65AW1 revised Fusarium oxysporum
44% to CYP65A1 Fusarium
sporotrichioides
FOXG_17343
MSRLVGFLINARSPSTCIFLLFAS (0)
LVLYLIGKITYNVFFHPLRKFPGPILWSMTQIPFSLA
WTSGAGHKKIYDLHQIYGDIVRVAPNELSFGYPEAWEDIMGHRKRGQAENGKD
PDFWRGNDIYTLVGSDRDRHSRLRKILSHGFSAQAMMEQQPIFQRYVNLMMKKLREASSSGQSVEMTQWLNWATFDMAGD
LIFGESFGCLEKVEYHSWVKLLYKHIEGFAVSTALIRYPFADTIIKLMTPKHVARDIKAHSDFTKAQVGKRMAYENPRPD
FMESMIRAYEKGHVNHAELLANAHNLIIGGSETTATTLAGTIYLLATHRPILMKLYAEIKERFRSEEEIDLLSVQKLEYM
FAVLHEGLRVYPAVPAAIPRKTSEAGMIGKHYVPANTIVSIWPWPMFHNPKFFKDAEVFVPERWLGDPKYADDKRVAVQP
FSVGPRNCIGKNLAYAEMRLILAKLIWNFDIDLDSRSEGWLGKNTAFLLWEKPELWVRLTPRSDI*
>CYP65AW1 Fusarium verticillioides
90% to CYP65AW1 Fusarium oxysporum = ortholog
FVEG_14125
MSRLLAPLVEFRSASFFISILFAS (0)
LLLYLVGKIIYNVFFHPLRKFPGPILWSMTQIPFSLA
WTSGAGHKKIYDLHQIYGDIVRVAPNELSFGYPEAWEDVMGHRKRGQAENG
KDPDFWRGNDIYTLVGSDRERHSRLRKILSHGFSAQAMMEQQPVFQRYVNTMMKKM
REASSGGQPVEMTQWLNWATFDMAGDLIFGESFGCLEKAQYHPW
VKLLYKHIDGFAISTALIRYPFADTIIKLMTPKHVAKDIKAHSDFTKAQV
GKRMAYENPRPDFMESMIRAYEKGQVNHAELLANAHNLIIGGSETTATTL
AGTIYLLATHRPILTKLYAELKERFQTEEEIEFLSVQRLEYMFAVLHEGLR
IYPAVPAAIPRKTSEAAMIGNHYVPAN (0)
TIVSIWPWPMFHNPKFFKDAESFVPERWLGDPKYEDDKRVAVQPFSVGPRNCIG
KNLAYAEMRLILAKLIWKFDIDIDPRSEGWLEKNTAFLLWEKPDLWVRLTPRSDL*
>CYP65AX1 Fusarium oxysporum
42% to CYP65B1
FOXG_17420
MLSVSILAGAVAATTVLCIGYVVYNIFLHPLRNFPGPLLCRASPLYRHYKFLRGDLLFETQRLHEQYGPVVRIRPNELSF
IDPEAWRDIYVAHGGSARLGDMARYDRFYQWAGPSAPETFVSLNRPYHDSMKRQLAPAFSERSLQFQEPIIQGYTDTLIR
KLTEVSKDGNPVNLREWFNYYTFDIIGNLGFGSDFGGLESEQYHPWVKAVSQNVREFAFMQVLMYLGLQRIVHVLSGSSL
LRGKILHEHLTREKVEARIKVEKPRLDIFQPLLDRKPPLTFAQLMENSTILITAGSESSVTLLVAAVSLLTDNPAKLQKL
AEEVRSTFNNDDEITIVSVNQLTYLAACLNEALRCFPAVPPALPRVVPHGGAVIAGHAVPEKTVVAVASWATNHSERHFK
KALEYHPERFLKDPEFSKDRFEAFQPFGLGHGNCPGRNLAWAETRLALARLVYNFDIESVPESRGWTTKQKAYMLWDKKP
FWAVLKPVR*
>CYP65AX1 Fusarium verticillioides
94% to CYP65AX1 Fusarium oxysporum
FVEG_12501
MLSVSILAGGVAATAVLCIGYVVYNIFLHPLRNFPGPLLCRASPLYRHYKF
LRGELLFETERLHKQYGPVVRIRPNELSFIDPEAWRDIYVAHGGSARLG
DFARYDRFYQWAGPSAPETFVSLDRPYHDSMKRQLSPAFSERSLQFQEPI
IQGYTDTLIRKLTEASKDGKPVNLREWFNHYTFDIIGNLGFGSDFGGLES
EQYHPWVKAVSQNVREFAIMQVLMYLGLQRIVHVLSGSSLLRGKILHEHLT
REKVEARIKVEKPRLDIFQPLLDRKPPLTFAQLMENATILITAGSESSV
TLLVAAVSLLTDNPAKLQKLSEEVRSTFKNEEDITIVSVNQLPYLAACLNE
ALRCFPAVPPALPRVVPHGGAVIAGHAVPENTVVAVASWATNHSERHFN
KALEYHPERFMKDPEFSEDRFDTFQPFGLGHGNCPGRNLAWAETRLALARL
VYNFDIESVPEGRGWTTKQKAYMLWDKQPFWAVLKAIR*
>CYP65AY1 Aspergillus flavus
40% to CYP65S4 Fusarium
verticillioides
AFL2G_11804
Note: there is no ortholog of this gene in A.
oryzae
MAARLLSSVSLTDVVLLLSSVWIAVHLVLAAYNVYLHPLRRYPGPKLAAASQLLNVYHVLKGDNCKWTAQLHEKYGTVVR
IGPNELSYISPSANQTIFGGRPKEDKVFEKNPVAYLQGNGDISNIFFARFHDHNRLRKLMAPAFSETAVREQEATIQGYT
NQLIAALRNRSGQAAYPDAKGVVNIIPWLHFILFDVLTRLSFGDPIGCLDRADYHPWVSVIFKAIIHSTYTQAAHRLAPY
QWILKHFIPNDMTANYEAHLEFTRKQLDQRQQVKEEPVARADFSSFMLKGMSPDELFDNVNIVITAGGETTASTISSSLY
YLVHNPSSYERLTKEIRDTFSAEGEITLAAVAALPYLKAVIQEAMRIHPPVPIGLFRVAPAAGAFIDGQWVPGNTWVSVA
NLAASRSPTYWRDPERFTPERWLGDAKYESDVREASAPFSIGTRNCIGLNLANANMRIILARLLWNFDFEAQPDNIDPHE
LDEYGIWETKPLNLKIKERVQTT*
>CYP65AY2 Penicillium chrysogenum Wisconsin
54-1255
AM920421.1
61% to CYP65AY1
MQLLEWVVALTGLVWHTQGSFTPSLEQSTNLVQ
364847
WIISHLCLAIYNVFFHPLRNYPGPKLDAATGLVYVYHMVRGNSCKYLAGLHEKYGEVVRA 365026
365027
GPNEISYMTVSANKTIFGNKTTEKMSFEKNPAVYIQGEGTAQNILFASTGEHPRFKKLMS 365206
365207
PAFSEQAIKEQEPTIQQYTSIMIDALRNNRSGEACYPDANGIANIGAWCNFLIFDILSCL 365386
365387
SFGKPIGCLQMADYHEWANVIFGAMKHSHFLQCAHRLKPYHRLLEKLIPGDISGPYETHM 365566
365567
QNVRKNLRERETMENLARADFASFIPKGMSEDELVDNVNILATAGSETTATTLSSLFY 365740
365741
YLTHNPDSYQKLVDEVRSTFSSEEEITFNAVASLKYLKAVIQETFRIHPSVPVGLHRITP 365920
365921
KAGSYIDGKWVPG 365959
365982
QTWVSVALLAAYRSPRYWKQPEDFLPERWLEDPEFASDNRQIWAPFSIGPRKCIGIN (2) 366182
LAYLNMRLIVARLLWNFDFDPQPDNVDPHELKEYGVWQG 366356
QVPLNLKIRDARA* 366398
>CYP65AZ1 Aspergillus oryzae
GenEMBL BAE63025.1
39% to
65S2, 41% to 65Z2
formerly CYP5118A1
MFVLPTTFMSVSHGIYQLLFLALLATAWRIYSNRFRHPLSHYPGPFFWTISRLPYAVTYAQGTLHRRVRQ
LHDVYGDVVRVAPDELSYRTEQAWKDIHGYSRNFPKDMRFYQTSKNKAPSVVIAPDGVHGRQKRSILRAF
SERAMKSHEHLLRPFVDSLIQKLQHASTSTEGGAVDLTEWYNYIMFDFMAHELFGQSLGCLENGVNHPWV
DMLFGSIKVWAFLSQSKYFPNLSWIIKTAVRLFCRDLLNHRSKKLGCIASKIPEGEGSDSSLPTFNSFLR
ANKGPHSTLSTEEVLSNHSFMMMAGSETTATLLSGCTFFLLKHPQVYKKLTSEIRNRFSSSTEMTFSSLA
NMAYLRAVLQEALRMYPPLPLGMPRVVPPGGAIISGQFVPEKTSVAVASWATYQSSSNFNTPQMFLPERW
LDTGPGDNDVKGAMQPFSVGPRACPGKNLAFGEASLILARLIWEFDLELSPQCSSWAYQRAYIIWDKGPL
LIKLTPRI
>CYP65BA1 Aspergillus terreus
43% to CYP65AF1
ATEG_07093.1 fusion gene revised
MTILADF (0)
VYLLASVGYDILFHPLANYPGPKLRAASLTPYLWALISGRHHTSVSDLHRQYGPVVRIAPNKLSYITPQAWKDIY
GHKKANEPEMAKDAKWQVADPNSPSTREQHGHYRRLFSNGFSNRSLREQEPLLQGYIDMLMDGLERAARDKHPVDIVQWF
NWTIFDIIGDLTFGESFECLEKATLHPWVGNMFQAIKGNMLIRVMQETPGLGPYTAGILRYVLPGKALKKREAHFQYTRE
KVNRRLGNLSPRSDFMDHVLHQPEGRGLTSPELLSNSSLLIMAGSETTATLLSGAVYLLLTNPGKMQKLVDELSTVFPGG
SMVNIKSTSRLTYLPAVIEETPALPAACCWDSSRCTGWRLGYRWTTSVAVHHLAAYHSPLNFEQPEDFIPERFIDTSAFQ
DQRDVLQPFSVGPRNCIGKNLAYAETRLILARLFSQFELELMSESDGWIDQRTYVIWEKPPMVGLTRRQGA*
>CYP65BB1 Mycosphaerella fijiensis
46% to CYP65AF1 Aspergillus
oryzae
45% to CYP563A2 Botrytis cinerea
44% to CYP65S2 Nectria haematococca
43% to CYP65Z2 Neosartorya fischeri
e_gw1.18.265.1 revised at N-term
MYSISTAAPLLALLV (0)
AVSSIVWKIVYNLYFHPLAKFPGPRLNAASSLPGIFALLKGRLPLENKKLHEKYGSVVRVSPNELCFNSVQAWEDIYGHRP
GHTNMHKDPIHVGSVEAVQGVSTLTMSDDENHARQRRALAHSFSQKALLEQEYIVKRYVDQLIVNMKRMADDDEAFNLVN
WLNFTTFDIIGDLAFGEPFGCLDLGRFHEWVALIYETVKAGAIEQATRRFAAAGSLTQRILFNMIPARVRGYRSEHLRRS
RAKCLQRLENGNSQHKDFIWYILKQREKHDLKQDEIIVNSALFIVAGSETTANLLSGLFARLIWNPDKYQKLVDEIRSSF
KSEDEIVYEKLSKLAYLNACIEEGLRIHPPVPTGLLRTVPKEGDTIDGQWIPGGTSVAVSSWAASHNPVNFRDCDSFIPE
RWLDKAYDTDYKKAAQPFSLGPRGCIGRHLSYMEMRLILGRLLWNFDVVSTDGAWQWNPEGEMKNMRAFMTWEKVSIIQY
YMQNSVLTRRSLT*
>CYP65-un1 Magnaporthe grisea
MG09636.4 poor match 39% to
MG02982.4
AACU01001669 cont2.1850 PSEUDOGENE
MANVSELQLSSNKSQFKSGSLKARQFCVDV
6111 IYNLCFHPLRKIPGSKLHGAT 6052
DELETION OF 143 AA
6020 DLMSQLVFGNSLGLLDGNPQYVGWVRAMLSGLKWVVL
TAVLMQVPLLGSLLQALATGPMKGIVGAHYRLASELVDRRLDPKSAHTGK
PDIWSFVIGRQPHETRKQTKDLTRDEAHVAASMLMIVGSETTATTLCGLM
YYLGRQANRRVHDRLAREIRSTIRNSDEIQNDPGMLAQMPYLNAVIQEGV
RLYMPGGITPRVVPGAGATICGEFIPGGTRVAYHSPAAFTNPMNFTRPHE
FLPERWLNPDDSEFAGDRRSVLQPFSVGPRSCTGKDLAWAELRMFLAKVI
WHFDVALCAESENWIVGQKTYISYQKDPMRCKFTPATAGSSGISSASS*
>CYP65-un2 Aspergillus flavus
45% to CYP65L1
AFL2G_11416
SSITTSSGLFRAIRSNCENIGSAGRIMVTELRNRVSFNSVTVNQCKYLVAVLQET
MRLWPAIAISLPRVTPPEGCEIDGSWVPGGTKVGVSQWSAYRSERNFARADQFLPERWLPEGEEESFINDTRAAFQPFST
GPRNCLGMNFARAETRIIFARLLLDFDLELLTGRDEWEAQKVYIIWDRCPLYVRVRQAKRR
>CYP65-un2 Aspergillus oryzae
45% to CYP65L1
100% to CYP65-un2 Aspergillus flavus
Supercontig 26: 405493-406148 (-) strand
SSITTSSGLFRAIRSNCENIGSAGRIMVTELRNRVSFNSVTVNQCKYLVAVLQET
MRLWPAIAISLPRVTPPEGCEIDGSWVPGGTKVGVSQWSAYRSERNFARADQFLPERWLPEGEEESFINDTRAAFQPFST
GPRNCLGMNFARAETRIIFARLLLDFDLELLTGRDEWEAQKVYIIWDRCPLYVRVRQAKRR
>CYP65-un3 Aspergillus terreus
36% to CYP65AQ1
one frameshift, possible CYP65 pseudogene
30/31 top hits are CYP65
ATEG_04028.1
MATAIISSLAFCLIILSISHKVVYNLYFHPLARFPGPSLWCASRIPYLWKLCRGKLPGKIRAYHDKYGPVVRIAPDELSF
DDPAAWREIYLDQTLEQPSRRRTKPTGLFMENLI
VAHPETQPRMRDALDLAFSEAS &
VDKYEPIVTRAIDRLIAKLKSSITKKNDGASALNIARCLELA
SFDIAAEVIWGSSFECLEGGQGNVVVDYALS
RKERLIAMALTFYPFLAFLSPLLSLSSTRTTTLQLFRRKTTERISKHQATSSGQQSQPDVLGSILQSRASETLPVTALEQ
TPVELVMDGGGPIAAVLIGTLNNLLRNPSKYDYLVQEVRGSFKRETDINGSATRPLPYLHAVVTEGLRIAPPFPDGVRRV
VPAGGITVAGCPVPPKTVVSTGCWVQFMNPRNFACPEEFVPERWLHAKGAGAIGGRTIVDTANKDAFYPFGLGARQCLGE
PLAWLELKLTLARLLWNFDISIPPEKTLPVWGEQDVFWTWNVQPMEVSLRLCRRF*
>CYP65-un4 Mycosphaerella fijiensis
46% to CYP65-un2 Aspergillus
flavus
e_gw1.3.1109.1
LRLYLPVPVVHPRRTPRGCCVIDGWWVAGDTQVSINQYAAHHDEEAFHRVHEYIPERRLPDRPDEFRNDRLGSVQPFHIGPRNCLG
&
MQNLAWHETRRLLAAVVLDFDVELAMRRKQW
>CYP65-un5 Mycosphaerella fijiensis
45% to CYP65AS1 Mycosphaerella graminicola
e_gw1.8.672.1
VVYLVTVAIYNIFFYPLARFPRPRLRAVSELLYFLCLVRGDTPKKTLDLYNRYSPIVRVSPNELSFISPVAIKEIYGSILG
RPELRKDNKYYSGIGEATLLFSDKEYYS *LRKRLVYSFL
ESALRL*EPII*QLVDVFIIYLKKES*A*RQIDLVK*YNFFAFDIISYLTYSETLDCLN
TSTLYI*V*KFRNLSRPIAFS*ALEKLLKLLRYPFIATFLTKKFISDYKTVYAVS
L*EKVSYSLNRISDTTGFLDKLIATYKEG
KITIF*LNSNATFLIATGTETLVALLVYTTY*LVIYPNKL*KATEEVRSKFADS*EMNIA
AIN*Y*YLLVCLDKTLRI*ALSLVTYPRFTPKDRLLIDS*FIPGNVAVRVLIFAAYRSKL
NFRNPNKFIPKR*T*EDPKYGNDRREAT*VFLVGLRDCLSRNLAYIEIRLILARLI*HFD
IVRLFPED*AE*KVYLV*EKPILIVKLKLVRNSIT*
>CYP66A1
Z82021 Agaricus bisporus (a mushroom)
WSYINSIVANSLWNSVKERMEAGTAKPCIATAMLEDLLDDDSAE
SKEEETVRRGACANGFLGGADTTVSLVTSFFMAMALYPDVQKKAQAELDQVLGGRLPE
FSDRPSLPYVNALLKESERWQPVFPLAIAHMSSNADEYDGYYIPKGTYVIGNAWSILH
DPEFYKDPLVFNPDRFLKDGEIDPSVRDPNVASFGFGRRICPGRFFPDASLYSTVTHV
LTVFDIKPNLDENGKEIGIKPDMTDGLLSIPM
>CYP66B1 Agaricus bisporus partial mRNA for
cytochrome P450 (cyp gene).
AJ271707
50% to CYP66A1
QLKSVRTFIRNVMESPDEFSEWIHFYTSSSIMEIIYGMKAKPED
PYVDNAKKAIEGFNEAAVPGKFLVETFPVMKHIPSWFPGAGWKRQALFWRDVNREVRV
RPFNLVKDQVNEGTATRSVCRTLIGNLPDSTAPDRIVKENIAIDTCAVSFIGAAETSH
SAARVFFMAMLMNPEVQKKGQAELDKVLNGRLPEPNDGPNLPYISAMVKETLRWQLVL
PLAVPHVAIEADEYNGYYIPKGTIVFGNSWTFMHDPEVYKDPESYMPERFLKDGKLDS
SIRDPSTAVFGYGRRICPGRYFALNALYLMIAHTLAVFDIKPALDENDNEKEFKADVT
GGMISQPVPFQCMIVPRSKAAADLIQNSDLME
>CYP67A1
Uromyces fabae U81739
FIVLISATAHFIFRRREPTAFQYACFQAGLALLLSVLLREPFGA
VVLILLALNFLLGVQIALYRLFWHDLRVFPGPRLAAITQGWILREAYLGRSRFSMKEV
GETYGDWVRIGPNELCTTSIEALSTIMGPKGWPKGPSYDSGITKGDSGGDSVLTIKNL
PEHATRRRIWNKAFTPNAINGYLPSIEIRLEEMLSVIDTEIKKGESVDLCLQLGCFVY
DTMCDMAFG ALAGSAFSKTQEDKYRILTHMGRVVRQVGIVRNMPWLTPIVKAWPSSHR
REQNEFKEFTKSMFLRRKNQGLGKQLDVFHYL
LGEDTETGTRLTEAELAADSTLLVI
TGADTTRTVLLAFFLYLLKHPNYMEQLQAELLAAPDLSPPSLSRLEYLNACLQETMRL
QPPSPANLQRICPPGGAVICGRQIPEGTKVRFSNYAIHRDERYFSRAEEFRPQRWLQKA
KDDLGNQGEEKERLDQRAFFGFLIGPGACVAKNLAWMEMRLVVATILTNFDLSFAPGF
DPVAFESSWTDAYLLLIEEPFEVMFTPKSQRMR
>CYP67A2 Puccinia graminis f. sp. tritici
76% to CYP67A1 Uromyces fabae
PGTG_03841 revised
MNYPASMNEFTSATFFSFLVIFPT (0
VAHLIFRNHEPTAIHYLCSQAVLFLLLEIGFQNSFFTGLLTLSAFNLSLAAQIAFYRLFWHDLR
SFPGPKLAALTQAWILREAYLGRTRFTMKELGEKYGEWVRI (1)
GPNELYTTSIEALYTIMGAKGWPKGPSYDSGITKGDLGGDSVLTIKS
(1)
LPEHATRRRI ()
WNKAFTPKAIAEYLPSIENRLDEMIGVIDDHVKQKRNVDLCLQLGCFVYN
(2)
TMCDMAFG (1)
APAGTGLLKNQGEKHRILTHMGRVVRQVGIVRNMPWLTP
LVKAWPSTQRKEQSEFRDFTKSMFLRRRNQGFGSQLDVFHYL (0)
LGEDTETGTRLTAAELAADSTLLVI (2)
TGSDTTRTVFLVFFLYMLKHPSYMEELQAELIAAPDLSPPTLARLPYLNACLQETMRM
QPPSPANLQRMCPPGGAVICGRHIPEGTKVRFSNYAIQRDERYFHDPDEFRPQRWL
RNAEEKLREGEDTERLNEKAFFSFLIGPGACVAKNLAWMEMRL
(0)
VVATLLTSYDVAFAKGFDPVAFEASWTDAYLLLIEDPFEVTFTPKAGRLR
>CYP68A1
Gibberella fujikuroi P450I gene Y15277
MANHSSSYYHEFYKDHSHTVLTLMSEKPVILPSLILGTCAVLLC
IQWLKPQPLIMVNGRKFGELSNVRAKRDFTFGARQLLEKGLKMSPDKPFRIMGDVGEL
HILPPKYAYEVRNNEKLSFTMAAFKWFYAHLPGFEGFREGTNESHIMKLVARHQLTHQ
LTLVTGAVSEECALVLKDVYTDSPEWHDITAKDANMKLMARITSRVFLGKEMCRNPQW
LRITSTYAVIAFRAVEELRLWPSWLRPVVQWFMPHCTQSRALVQEARDLINPLLERRR
EEKAEAERTGEKVTYNDAVEWLDDLAREKGVGYDPACAQLSLSVAALHSTTDFFTQVM
FDIAQNPELIEPLREEIIAVLGKQGWSKNSLYNLKLMDSVLKESQRLKPIAIASMRRF
TTHNVKLSDGVILPKNKLTLVSAHQHWDPEYYKDPLKFDGYRFFNMRREPGKESKAQL
VSATPDHMGFGYGLHACPGRFFASEEIKIALSHILLKYDFKPVEGSSMEPRKYGLNMN
ANPTAKLSVRRRKEEIAI
>CYP68A1 Gibberella proliferatum (teleomorph sexual form)
MTNHSSSYYYEFYKDHSHTFRRSMSENTLISSCLALATCAILLS
IQWLKPQPLIMVNGRKFGELSNVRAKRDFTFGARQLLEKGFKMSPDKPFRIMGDVGEL
HILPPKYAYEVRNNEKLSFTMAAFKWFYAHLPGFEGFREGTNESHIMKLVARHQLTHQ
LTLVTGAVSEECALVLKDVYTDSPEWHDITAKDANMKFMARITFRVFLGKEMCRNPQW
LRITSTYAVIAFRAVEELRLWPSWLRPVVQWFMPHCTQSRALVQEARDLINPLLERRR
EEKAEAERTGEKVTYNDAVEWLDDLAREKGVGYDPACAQLSLSVAALHSTTDFFTQVM
FDIAQNPELIEPLREEIISVLGKQGWSKNSLYNLKLMDSVLKESQRLKPIAIASMRRF
TTHNVELSDGVILPKNKLTLVSAHQHWDPEYYKDPLKFDGYRFFNMRREPGKESKAQL
VSATPDHMGFGYGLHACPGRFFASEEIKIALSHILLKYDFKPVEGSSMEPRKYGLNMN
ANPTAKLSVRRRKEEIAI
>CYP68B1
Gibberella fujikuroi P450II gene Y15278
MSIFNMITSYAGSQLLPFYIAIFVFTLVPWAIRFSWLELRKGSV
VPLANPPDSLFGTGKTRRSFVKLSREILAKARSLFPNEPFRLITDWGEVLILPPDFAD
EIRNDPRLSFSKAAMQDNHAGIPGFETVALVGREDQLIQKVARKQLTKHLSAVIEPLS
RESTLAVSLNFGETTEWRAIRLKPAILDIIARISSRIYLGDQLCRNEAWLKITKTYTT
NFYTASTNLRMFPRSIRPLAHWFLPECRKLRQERKDAIGIITPLIERRRELRRAAIAA
GQPLPVFHDAIDWSEQEAEAAGTGASFDPVIFQLTLSLLAIHTTYDLLQQTMIDLGRH
PEYIEPLRQEVVQLLREEGWKKTTLFKMKLLDSAIKESQRMKPGSIVTMRRYVTEDIT
LSSGLTLKKGTRLNVDNRRLDDPKIYDNPEVYNPYRFYDMRSEAGKDHGAQLVSTGSN
HMGFGHGQHSCPGRFFAANEIKVALCHILVKYDWKLCPDTETKPDTRGMIAKSSPVTD
ILIKRRESVELDLEAI
>CYP68C1
AY040587 Fusarium sporotrichioides TRI15 gene
MSKVDKTGYAQWVYLLPERSSMMSFIDSMEDFRFDMLIYFLCFV
VLGRAVQWFLRPKPNAPLLNPRRFFEFSDSRAVSEILYSTRQVLEDWFSKYPTKPMRI
IADLGQITILPPSMADEIKNDPRLSFIKASTESAFHITIPGFEPFREGAKNEAGLIKN
VLHKHLNKTLNHITTPLAEETCLAVQEYFGSDQGWHKVPLRDTLVPLVTRISTRIFLG
QDLCRNQEWLRIAASYSSTSAEVANHLRRWPKPLRYLVSLLSPECQNLAKQVRNARAL
INPILERRRVEEGQEKGTSYNDSLEWFERYAREAYDPAATQLFLSVVSIHTTTDLLCQ
ALEDISSHPEIIKPLQHEIREVLKQEGWNTKALYKMKLLDSVLKESQRLKPVQHATML
RLALEDITLEDGTFIPKGHQISVSCHAMRDNEIYENASSWDGYRYYRQREQSANEHKA
QLSSTSPEHMGFGYGIHVCPGRFFAANEVKVIMIYLLLQYEWRTPPGSQPKPLSWCTT
WATDPTFELEVRRKGSDDIPVELSHNTFSRESES
>CYP68C2 Fusarium graminearum FG00071.1
AACM01000004 FGcontig1.4_scaffold1
MALITSLQDVRLDMLAYFVAFLVVVSVVRKKLAPQPSAYLLNPRRWYEFT
DARAVSEVLHTTRQTLEEWFHKHPTTPVRLTTDFGEMTFLPPTLADEIKS
DKRLSFIKAANDSAFHTEIPGFEPFREGGRNEAALIKEVIHGQLKKTLNK
MTFPLAQETQLAVEHYLGANKEWHKIRLRDALLPLVTRISTRIFLGEDLC
QNDKWISITSEYAANSLEVANRLRVWPKYMRYVVSYFSPGCGILRNQVKN
ARELITPIVERRRSEEKGKEYNDSLGWFEKTAKQAYNPAATQLFLSAVSV
HTTTDLICQCLEDIAAHPEIIKPLQEEIRRVIAEEGWNTKAMYKMFLLDS
VFKETQRLKPIQVASMVREAQSDITLSDGTFIPKGHQIAVSCHNMRDGRI
YENPEKWDGYRFFRERQQSAREDKVQLSSTSVEHMGFGYGEHACPGRFFA
AKQVKIVMMYLLLNYEWKIPEGPEPQLMAWCTTWVTDPDYEVLMRRKDKD
DPCLRLELVQDD*
>CYP68D1 N.
crassa AABX01000146.1 cont3.306 NCU05376.1 (version3)
10526
MANPSATPSSIPSWMERLDIKSITDPSATPFSYLVTAFLLAVVV
YSLQGPRFPKNIKHLNPKGPLEFSDTRPKKEFVYGSRQMLANWF
KANPNKPCRVISDFGEAIVLPPRMANEIKNDDRLSFTRWTYK (0) 10915
10981
AFHGHLPGFEGFGEASRESHIVQEVIMRDLTKYL (1) 11082
11140
NKVTEPLAQETSMAMEANLPKAANGEWSTINLRSKI
LPIVARISSRVFLGEELCRNEEWLKVTQQYTIDGFGAAEDLRLWPAALRP
IVHWFLPSCQRARADVRVARSILDPVLKKRRQEKAANGGKAEHDDAIEWF
ERTAKGKYYDPAVAQLVLSLVAIHTTSDLTCQVMTNLMQNPEFIAPLREE
MIQVLSEGGWKKTSLYNMKLLDSVIKESQRVKPTGVASMRRYAEKDVTLS
DGTFIPKGGFVAVSAHDMWNSEVYEQAEKWDGRRFLRMRETPGAGKENVA
QLVSTAPEHLGFGHGQHACPGRFFAANEIKIALVHLLLNYEWRLPEGSDP
KIRTFGFSMGVDPSLKVEYKGRQPEIEL*
12234
>CYP68D2 Nectria haematococca
e_gw1.16.35.1
Necha1/scaffold_16:246007-247770
55% to 68D1 48% to 68C2
This gene model seems correct
MLVKELLEAPWAFLNSTASASNIRLSYFVAPLIAITVACFFFTSKPNAPCLNPQGFFDIASGRAKKQFLF
GLRSMLKTWFDANPHKPASVFSDIGPMTVLPPSMANEIRSDPRLSFVEFSAK
(0)
FFHTSIPGFEAFNEGTRDSITLTVINKDLTKRL (1)
AQVTQPLAEETTLAMQEIFTDNK (1)
EWHLINVREKILHLVARISSRVFLGEELCRDE
AWLKITREHAMNGFVAADLLRAWPEALRPVVSWFMPHCRTARSQIREAEKIIGPVISKRREAKDAALRAG
REAPIHNDAIEWFEQASKGKPYNPALSQLFLSTVAIHTTTDLLCQTMIDIARHPEYFEPLREEVTRVLAQ
DGWKKTSLHSMQLLDSVVKESQRLKPLQL (1)
ASMQRLAVKDVQLSDGTFIPKGTASCVSSHALWDPDVYEAP
DTWDGHRFLRQRGIPGKENFSQLVSTSENHLGFGHGKHACPGRFFAANEIKIALAHLLLEYEWRLPEGEA
LDVEDFGITPIMNQTLKMEFRKRD*
>CYP68D3 Aspergillus niger
e_gw1.6.1239.1|Aspni1
60% to CYP68D1
MPVPVLVSLALGLAFLLLQSFRYKDPALNPKKPFELTSTRVKQEYFSNARRLLWDWFTTHSNTPVLLHTDTGKVTILPPS
MANEIRNDDRLSFSRWTFEAFHGNLPGFDGFREGSQDSGIVQAVIGNDLTKYLNKVTEPLANETSVAVRELLTDNEEWHT
IQLRTVMVALISRISSRVFLGEKLCRNEEWLRVTQDYTTDGFLAAEELRMWPAAIRPIVHWFLPRCRKLRAQVKVARKVM
GPILEERRQFKKHLHAKGKQSQGFDDAIEWFEKAAKGRPYDPVSAQLILSVAAIHTTSDLTSQTMTHLVQNPEILEPLRK
EIVDTLQQHGWKKTALYNMKLLDSVIRESQRLKPINNASMRRVALKEVKLSDGTVIPKNGMLAVSAHKLWDDDTYENAAA
WDGYRFYKMREDPERQTKAQLVTTAPENLAFGHGKHACPGRFFAANEVKIALIYLLLRYDWKLLEGTVPKIRYGGFSMAV
DPSLKMEVKRRREEMGI*
>CYP68E1 Magnaporthe grisea MG10527.4 with C-term extension = accidental
fusion
AACU01001764 cont2.2024
MSTLELFSNITSPVSDDLRDGTAFKYAPYLVTAIFVLAIVYSKRESYPDL
PRLNPKGPLEFGWAKRLNHFMVHSPELLAEASRRFGDNPFKLFTDLGDIV
VVPAKYANELKNHRGMNFMEVGVDSVHTYLPGFEPFAATPALVKVVNNNL
TKTLAKLTAPMVQEAALGSSDIFGESKEWHEVSIEQIMGFILRISSRIFI
GQELCRSKQWLEASRAWTHVAFQAVFTLRAYPRFWRPWIHWSIPCVNDSR
RKLKLCREVLQPYIDKRNIVKAEAIARGEPSPFDDSIEWFEQENKTDFDP
AQKQLQLIVAAVHTTTDLLVVALVNIAKNPEIIGPLREEIISSLSEEGLK
ISAFEKLKLMDAVFKESQRLKPIATIAFRRKAMEDVVLSDGFKIKKGTII
GIDGIKALRDERVYPDPLRWDPYRYIKLREAGEAAKARLVSVTQEHFGFG
HGFHACPGRFFAANELKIALARIILNYDITVPEDVKNLPEAFSGSNYKIP
KGTRFLFKRRKEELDLSTLV*
>CYP68F1 Magnaporthe grisea MG00300.4 36% to 68A1 35% to 68D1 AACU01001402
cont2.70
MANETFSAISQPGAFPGLGAQTSAWASYVVAALLLASLAYSRRDKYRGVP
DVTPSRPFELTDSRKRKEFLAKSREILAQGSKRYGDQPYKVTAEMGQILV
LPPQYVAELKNNPALDLTAFVQKILVHAYLPGFEPFGAAEATVKIIPKYV
NKKLGNLALSDIFTDSKDWTEIDAFSILRLASRMSSRIFMGKDICKDPVW
FKALLDYISDIGAQRNIISGWPLSLRPIIYRLVPASFRIKRKLQKCRDVL
KPHLERRAAIIKDALARGEPNPFDDSIQWYENEVGDGEKDHAVFQIGIFL
VAIPNTADTLMQTLHHLALNPEYISVMREEVIRVIGTHGLNKAALQKLDF
MDSCLKESVRLRPVLTLYFQRMALQDVTMSNGFTIKKGTVLGMDGTRMMM
DEDIYPEPERYNPRRFMEMRKLPSGASKAPMVTVTPDHHAFGHGIHSCPG
RFFVTTALKIALAHMVLKYDWKVAEGYEDAKPRVMGMRYLASNVKLQVRR
RKEELDLDSLAAQTK*
>CYP68G1 Magnaporthe grisea MG03834.4 40% to 68B1 AACU01001031 cont2.748
MNSPNQSVQPSSAAYAGPEQPLVSSMFERTPLLGLGLSVAVATLFLGKFL
FGGGSSKKLAFPLVKKDGDGYNFLSDALKMVEKGRSQHPGMPFFIEGENG
PLAIIPPNMIDDIRSHEDLSFHLTVREDFHDGMPGFEAFTITSRGGGVLQ
TVISKQLTKYVGVILNNLSDEAAYALHKNFGDDTEWREHTIKPIILDTIS
RVASRIFLGEDLCRNEEWLELSKGYTIAAFMAARDLRQRPFHLRRLMQWF
EPSCKTLRRYRDSSRALILPIVDKRRALRRECIAQGRPLPVFNDCIDWFE
EEAAGRDYDAGMIQQAIAATGNHTSSDFTTKFVLILAEHPEVQQEIREEI
VRVLGAEGLTKAALANLKLLDSAMKETQRLQPLTTSPMARMATKDIHLAN
GVCIPKGTPLVIDGSWRLSPDIYENPLEFDAHRFLKWRGTDRENMAHFVS
TAASHTGFGHGIYACPGRFFATNELKVILCQLILKYDWKLAEGSTAEPLV
FGFNLDASWDAKIMVRRRKVVELDIDALSA*
>CYP68H1 Magnaporthe grisea MG02294.4 41% to 68B1 39% to 68D1 AACU01000444
cont2.449
MASSINASPTWPQGQLPGLSALASLDLDRSTIAITLAAIVILPLLVSYIA
SSLRGEKVPVVNPPGRFQTALQKSIEFGTAGFKIFQQAQEQFPNQPFKLL
SNAGYTTVLPPDRALEVKQHPNLSFRKAFSTILPANSEGAAALGVVDHPS
EIIQKIVTKHLTKRLNSVTAPLSLETSVATEKNFGKSSEWTEIKVYEPIT
DVIARVSSRVFLGDKLCRDAAWLDITKSFAQTAMAVIMTMRAFPTWIRPL
VFQFASYGKEYRALYRRGHNAIMPIMKERQEERAECAAKGVPAPVYNDLI
EWAETEAGNNSFDMTAVQLSISMAAIHTTSDLVSQNILLLSTRPDFVDAL
RKEMIEVLPAKGWKKTSLTSLRLLDSAIKEAQRLKPTSVIGMQRLVMKDT
VLEGGITLRKGEYSAVDATRVWDPKLHKNPDEFDIYRFYEARKQPGGEHV
HQLVSTSPDHIAFGLGKYACPGRFFASNETKVVLCHLLLKYDWKLAEGSS
TDFTYFGTELTINPETKVLYRRRKEEFDLDALATDEEAS*
>CYP68H2 Magnaporthe grisea MG11075.4 38% to 68B1 AACU01001898 cont2.2223
MASSSKLDLAWLQKQPVGQGFLEMSQSTIAVTLAALVLVPVIASYIFAGR
KGAAEIPLMNPPGPFELALSKAVQFPQQGLDLYNKARKLFPDQPVKFITN
AGTLTILPSDRAQEVKGIRSLDFRKSFSYSAPLTAPGGAALSTFDHPNEI
VQTVVSKYLTKRLRPLASEATFTINKNFGNSPEWTEVKMYDVGLDVVARL
SSRVFLGSEICRNEEWLETTKRITMVFTSVLQTARVYPTWLRPLVYRFGK
HGRDMMAVTKQVNDIVNPIVEKRKLEMAECEARGEPAPVYNDAIEWILSE
HDPNDRIFKVADFQIALSVAAVHTTSDLLSHTMLTLAANPQHIEPLRKEM
IEVLGTGGWKKTSLTSLRLLDSAVKEAQRIKPVQRVSMQRLVTEDTTIEG
GYRLRKGELVGVDTYPLRDPAKWPEPETFDPYRFYQARKQPGGEHKAQLV
SVSPDHLTFGYGKYACPGRFFAANEVKLALCHLLLKYDWKLPEGGSDQPI
MFGLDPIVNPGATIMFRRRKEELDLDSLLVDSEE*
>CYP68H3 Magnaporthe grisea MG00024.4 41%
to CYP68B1 41% to 68D1 AACU01001352 cont2.7
MASSVHADSGWLRKQVMGSSGLELLDSSRFTIGITLAALVLLPVVASYLT
GARKGKEAPLVNPPGLFQLAVQKNIEFVHKGNYYLKEARRRFPNQPFKLL
TNGGPMTVLPPSRSNEIKNMESLDFRKVLSYAAPVNLPGGSAIAAVDHPQ
AIIQTVITKNLTKRLNTVTGPLADEASFAINKNFGSNPDWVEAKICEPIT
DVVARLSSRVFLGEEICRNEEWVDLTKKIAIVVLTCIYTLRAFPQWMMPI
VYTFGKAGKDMRAMRTRVIEIIHPIIDKREQEKAECKAQGIPAPVYNDAI
EWVAAEADPNDPVFKLGDFQIGLSVAAIHTSSDLLGYTLLWLAASDPAYI
DALRKEIVEVLGKKGWKKTSLVSMKLLDSTIKEAQRLKPVQLAIMQRRAM
KDIESEGGVTVRKGELVAIDSNRLRDPAYYPNPDTFDPYRFYNARKQPGG
EHKAQFVSVTPDHLTFGYGKYACPGRFFAANEIKLALCHLLLKYDWKLPE
KAPPKPLIIGIDPLVDPEARLLFRRRKEEIDLDSLDVENEE*
>CYP68J1 Fusarium graminearum FG02672.1
AACM01000132 FGcontig1.132_scaffold1
MICRALDASTVCSYKTQHSSSMATDLDLVLGKSQYALFCGITLFSFFILK
YSLLGNGGKQYPYINPKKPFELSNQRVVQDFIENARDILTKGRSLYKDTP
YKAHTDLGDVLVIPPEFADALKSERQLDFTEVARDDTHGYIPGFEPIGSP
FDLVPLVNKYLTRALAKLTKPLWAEASLGVNHVLGTSTEWHPINPGEDIM
RIVSRMSSRIFMGEELCKDDDWLKVSIEYTVQLFQTADELRNYPRWTRPY
IHWFLPSCQGVRRKLQEARDLLQPHIDRRNAVKKEAIAEGRPSPFDDSIE
WFENEYEGKSDPATEQIKLSLVAIHTTTDLLSETMFNIALQPELLGPLRE
EIVTVLSTEGLKKTSFYNLKLMDSVIKESQRLRPVLLGAFRRMALADVTL
PNGDVIKKGTKIICDTTHQWNPEYYPDASKFNAYRFLQMRQTPGQDKRAH
LVSTSHDQMGFGHGLHACPGRFFAANEIKIALCHMLLKYDWKLPEGVVPK
SKALGMSLLGDREAKLMVKRRAAEIDIDAIGSDE*
>CYP68J2 Fusarium graminearum FG04717.1
AACM01000196 FGcontig1.196_scaffold3
MSTYIDIVLENPQYAVLSTISLIAILIANYSFFAKDDKYPVLNPKKPFEW
SNTRVVKEFTENSKSLLAHARSVYGEQPYRAYTDMGKVLVIPPSWVHALR
SKKELDFRIPAQEDSHEYIPGFDGFGFHANMPTVITKYVTKSLAKMTGPI
SEETSLSIRDRLTDSKEWHSINPPKEMIRIVSRVSSRIFMGKELCRDEAW
TKASSDYTVVAFASIALLRVYPRWLRPYIHWFLPYCKEARRLLKEARECL
QPHLDRREVIKQQALAQGQPCPFDDAIEWFNNEYDKHDPATQQISISIVA
YHTTSDLLCETLLNLCQHPELFKPVRDEIITVLRQEGGITKAALYNMKLL
DSVIKESQRLRPILLGAFRRKAMADVTLPNGDVLRKGDRVIGETTHMWGP
ESYDNALEFDPYRYVRMRESGEENKAHLVSTSPEHLGFGHGVHACPGRFL
AANEIKILLCHLLLKYDWKLPEGAEPKPSFASFRIDGDKTTNLLIRRRTE
ELDIDSLSA*
>CYP68J3 Fusarium oxysporum
68% to CYP68J1
FOXG_10386
MSSYLDLLLGNPQYAIFCGVTLFTLFVIRYSLLGHVTKFPVLNPKKSLELTSNRATQDFIADSKNILTNGRALYKDQPYR
AYTDWGKVVVIPPKFLDALKSHKQLDFTIPAEDDSHAYIPGFDPFVSDPNISKVVTKYLTKSLTKLTAPLSEEASLAFRQ
VLTDSTEWHEMHPQHDIVRIVSRMSSRVFMGESLCRDDEWVRASGDYTVQSFKTGDILRTDPRCSRPFVHWLLPSCWTLR
KKLAEAIQCLKPHLERRSCISAEAEAQGKPSPFDDSIEWYKKEGSTRNPALLQISLSLVAIHTTSDLLMETLFNIAQHPD
LFQPLREEITDVLTTEGLKKTALYNLKLMDSVIKESQRLRPVLLGSFRRQAMADITLPNGDVIKKGEKIVCDTTHMWNGD
YYEEAAKFDGYRFLRMREASEQDKHPHLVSTSFDHLGFGHGNHACPGRFFAANEIKIALCHMLLKYDWKLADGVVPKPSG
FGMAYLPDLQAKLLIRRRTEELDIDSIETC*
>CYP68J3 Fusarium verticillioides
95% to CYP68J3 Fusarium oxysporum = ortholog, 60% to CYP68J4
FVEG_09038
MASYLDLLLGNPQYAVFCGVTLFTLFVVRYSLLGHLTKFPVLNPKRSLELTSNRVTQ
DFIIDSKNILTNGRALYKDQPYRAYTDWGKVVVIPPQFLDALK
SHKQLDFTIPAEDDSHAYVPGFEPFVSDPNISKVVTKYLTKSLTKLTAPLSNEASLA
FRQVLTDSTEWHEMHPQHDIVRIVSRMSSRVFMGESLCRDDEW
VRASGDYTVQSFKTGDILRTYPRWSRPFVHWFLPSCWTLRKKLDEAIRCLKPHLERR
SVISAEAEAQGKPSPFDDSIEWYKKEGSTRNPALLQISLSLVA
IHTTSDLLMETLFNIAQHPELFQPLREEITNVLSAEGLKKTALYNLKLMDSVIKESQR
LRPVLLGSFRRQAMADITLPNGDLIKKGEKIVCDTTHMWNGD
YYEEAAKFDGYRFLRMREASEQDKHPHLVSTSFDHLGFGHGNHACPGRFFAANEIK
IALCHMLLKYDWKLADGVVPKPSGFGMMYLPDLQAKLLIRRRNE
ELDIDSIETQ*
>CYP68J4 Fusarium oxysporum
70% to CYP68J2 Fusarium graminearum
FOXG_16939
MTAYINTILQNPQYAVLSAISVITLLVVNFSFFTQQEKYPILIPKKPFELTNTRVVKEFIANSRSLLANARTVYKDQPYRAYTELGKVLVIPPSWVDALKSNRHLDFQTPARD
(0)
DSHEYIPGFQPFGGSHKLTTVINKYITKAL (1)
MVKLTGPISEEASLSIRDTLTNSR (1)
EWHPIRPQADLIRVVSRVSS
RIFMGEELCRDEEWNRTSSEYTLLAFGYGGLLRSYPRWLRSYIHWFLPQCWEVRAKLNEARQCLKPHIERRKVIKQKALAEGK
PSPFDDSIEWFEKEYEKHDPATEQIAVSIVAYHTTSDLLAETLLNLCQHPELFQELREEIIAVLTAEGGLTKGALYNLKL
MDSVVKESQRLRPILLGAFRRIATADVTLPNGDILKKGDKIIGGMSHMWDSDTYDNALEFDPYRFVKMRQTGDDKKAHLV
STSADHLGFGHGFHACPGRFFAANEIKILLCHMLLKYDWKLPEGCKPQPSHSGFKLLGDYSSNLLVRRRTEELDIDSLSS
SKGHDSLPY*
>CYP68J4 Fusarium verticillioides
83% to CYP68J4 Fusarium
oxysporum probable ortholog
FVEG_13755
MSAYIDTILQNPQYAVLSAISLITILVVNFSFLTKDEKYPFLIPKKPLELSDRR
VVKEFLANSKSLLANSRKVYKDQPYRAYTEIGKLLVIPPSWVEALK
SNRQLDFLMPTKDDAHQYIPGFDPFGFDPKMPTVINKYITKALTRVTGPVS
EESALAIRDCLTDSKEWHGVKPQEDLIRIVSRVSSRIFMGEELCRDEEW
TRVSSEYTLMSFGYGHILRTYPRWLRPYIHWFLPQCWAIRAKVNEARQC
LKPHIDRRNAIKQKALAEGKPCPFDDSLEWFEREYEKHDPAKEQIAVSIVA
YHTTSDLLAETLLNLCQHPELFQELREEIITVLTAEGGLTKGAMYNLKLMD
SVVKESQRLRPILLGAFRRTATADVTLPNGDMLKKGEKIIGNMSHMWDS
DTYDNALTFDPYRFVKMRQTGDDRKAHLVSTSTEHLGFGHGIHACPGRFF
AANEIKILLCHLLLKYDWKLPEGCKPQPYFSGFKLLGDFSSDILVRRRTEELDIDSLSQS*
>CYP68K1 Fusarium graminearum FG11002.1
AACM01000457 FGcontig1.457_scaffold8
MIDEIKNDRRFDFGAAASDDNHAYIPGFGALMHDPVMPKVIGRHLTKALV
LPAALGASANQLLQEWHILNVNEDISTIVSRMSSRVFMGEDLCRDQGWNN
ASAYYTRKTFKAMMILCVIPRWLRPYIHWVLPQCREVRRALAAARKELNP
HIERRERTKAEALARGEEPPFDDAIEWFAQSGSELPPADCQIALTLAAIH
TTTDLLSQTMVNIATYPEIFTALREEITRVLSEQGLKKTALADLKLMDSF
LKETQRMKPILIGWRRRALADVTLSNGMTVKKGNKVVVTAIHMWSDGNYN
NAKTFDPCRFVPKDKEQMSYLVNTSANHLGFGHGTHACPGRWFASNEVKI
ALCHLLLKYDWKLVDGKVPEPVAFGMAYVANPEAKLLIRRRKEELDLSML
EY*
>CYP68L1 Aspergillus nidulans AN8530.1 45%
to 68A1 54 clan
MDSLSLSNSQSIAGVLALLLLSGIYVYLNSPSYPVVNGKRPWELRIIHAQ
KRFLSNARDLIDSGLARWPAFHLVTEAGYRLVLDPKYANEIRSHEALSFG
KATAQDFHAGIHGFEPFEQGTRSDQIVSDVVRMKLTQSLGNVTKPLSDET
AIALQKNWTDEADWHTIPVKKTVLDIVAQLSSKVFLGDQICRNPEWLRIT
VAYTVDSFLAAQALRMWPTFMRRLVAPFIPGVQKIRAELEEARRIILPVL
EKRKAEKQTAIAAGKTPARYNDAMEWMEQCAKGRPYDAAVSQLSLSLGAI
HTTSDMLTQVLYDICGHSDLVDELRQEVLTVIAAEGWQKTTLYKLKLMDS
VLKESQRVKPIGIVKLSDGTVIPKNANLIVSSQRMWDESIYPSPDKFDPY
RFLRLRETPGHETSAQFVSPSPDHMGFGFGKHSCPGRFFAANEIKIALCH
ILLKYDFRLTEEWRNPRPIASGAGLTAEPRATMEIRRRKEEIQL*
>CYP68L2
BAE66422.1 [Aspergillus oryzae]
MLGDLFESVLTNNSVTLLITVAVAAIALHLSSPKSNLPLVNDKKPWEFRFTKARKRFLANAHNLIKAGLA
KAPAFRIVTGNGKRVVLDAKYANELRSHDDLSFGLHIADNFHAHIRGFQPFKQGSNDDEIYQNAVRMKLT
QSLGNLTQPLVDETLVALQTYWTNDTNWHAIPLKSNIQKVVAQLSSRIFLGDQICRNPNWLRIAVDYTVD
AFKAAEELRLWPKAFRAIVALFLPSCRKIRAELQEAQDIIRPVLDARRKDKQAALSAGKEPERYNDAMQW
LEECAKGRSYEPAFGQLTFSVAAIHTTSDMLTQVLYDLCGRDALIQALREEVITVVQEEGWTKPTLYKLK
LMDSVLKESQRLKPISVVSMQRVATADLRLSDGTFIPKGTSLAVSSDRMWDSEIYPNPLEFDGYRFLKLR
ELPGHETSAQVVSPSPEHMGFGFGRHACSGRFFAINEVKIALCHILLKYEFKLADGSVPRATKFGFSFTS
DPTTKLMIRRRQEETVL
>CYP68L2
Aspergillus flavus
97% to CYP68L2
Aspergillus oryzae
AFL2G_11735
MLGDLFESVLTNNSVTLLITVAVAAIALHLSSPKSNLPLVNDKKPWEFRYTKARKRFLANAHNLIKAGLAKAPAFRIVTG
NGKRVVLDAKYANELRSHDDLSFGLHTANYFHAHISGFQPFKQGSNDDEIYQNAVRMKLTQSLGNLTQPLVDETLVALQT
YWTDDTNWHAIPLKSNIQKVVAQLSSRIFLGDQICRNPNWLRITVDYTVDAFKAAEELRLWPKAFRAIVALFLPSCRKIR
AELQEAQDIIRPVLDARRKDKQAALSAGKEPERYNDAMQWLEECAKGRSYEPAFGQLTFSVAAIHTTSDMLTQVLYDLCG
RDALIQALREEVITVVQEEGWTKPTLYKLKLMDSVLKEIQRLKPISVVSMQRVATADLRLSDGTFIPKGTFLAVSSDRMW
DSEIYPNPLEFDGYRFLKLRELPGHETSAQVVSPSPEHMGFGFGRHACSGRFFAINEVKIALCHSLLKYEFKLADGSVPR
ATKFGFSFKSDPTTKLMIRRRQEETVL*
>CYP68L3 Histoplasma capsulatum G217B
ABBT01000111.1 Ajellomyces capsulatus G217B
382612-384420 (-) strand
57% to CYP68L2
HCB03354.1 revised
384420 MLLETMLNSSMPSTLGLAAIFILLPALFFQVTLPKKSRLPLINGKKLSEFSYTHSGKRFLK
(0)
VNARILVDEGLGK
384118
ARAFRLMTDNGPKTVLSAGYADEIRSHPLLNFGAAIAKEFHADIRGFDTFKQGTRADEIFQDAVRMQLTH
HLGNVIEPISTEASIILERDWTNNHGWHDIVLKKSVLKIVAQLSSRVFLGEKLCRNPDWLRITISYTVNSYIAAQALRLW
PEIIRPLVANFLPSCRKLRREIEEARAIINPVLEERRQAKEGAIRVGKTPERYLDAMQWLEESARGRYYDPVVAQLSFSH
AAIHTTSDLLTQVLFNLCGRDELTQKLRDEIVTVTQAEGLKKTTLFKLKLMDSVLKETQRLKPVAVATMRRLAEEDIELS
DKTFLPKGELIVVACDKMWDPDTYPNPSTFDPYRFVKLRERPGHEMSAQLVSTSPEHLGFGFGKHACPGRFFAANEIKIV
LCHILLKYDIKLADGCEPRIRSNGLSLNADPIARISIRRRAD*
382612
>CYP68L4P Aspergillus clavatus
ACLA_047580
AAKD03000015.1 117585-116726 (-) strand mid
region is 63% to 68L2
MLLDIKTQFSRLVPFSIAGVLALSALFIFLTLPRKSLLPMVNRKGPWEIRSYRVQNKCVQDARKSIKTGLSK
EAMQWMEECAKGRPYDAAVAQISFSLAAIHTTSDMLTQVLLDLSEHEQLIQELREEIVTVIRSEEWKKTTLYRLKLMDSVLK
KSQRLKSIGVATMRRLAEEDIKLSDGKLVPKGTSLLVFNETMWDPSVYPNPETF
ILLKYDIKLAKGCKPTMRMNGLSMNADYFAKVSVKRRQEETLL*
>CYP68L5P Aspergillus fumigatus Af293
XP_752004.1 also EAL89966.1
Internal fragment, needs revision
Pseudogene fragment mid region aa 183-260
62% to
CYP68L3 Histoplasma capsulatum
74% to
CYP65L5P Neosartorya fischeri
formerly CYP5088A1
KICRNPDWLRITVGYTVDTF &
LPAENLQLWPRLIRPVVAKF &
LPPCRKICWELKEATEIITPVLEERQ
>CYP65L5P Neosartorya fischeri
62% to CYP68L3
Supercontig 569: 1883929-1885384 (+) strand
MAASRIATCMKDKMLTDISTQLFRLDP
ISLAGVLAISGLFFLLTLPSKA &
SIPMVNVKKLFQIRSSHIQKRYLDACKLSKTGSRK ()
APSFRVHSDNGIKTMLAPEYANEFHAHPALRFGRAITLEFHSD
&
FLGD
KICRNPDWLLITVDYTVDTFFAAEDLRLWPRLIRPIVANFLPSCRKIRRELKEA
PVLEERR
DLEAARKANQPQKRYHDAIQLMEECAKGQHYPPAEAQMAFSIVAIHTTSDMLT
QVLLDLCANPEVIQPLREEIVAVNQEE*WKKTALYKLKLLDS
VLKESQRMKPVNI
ASMRRLALEDIKLSDGTLIPKGSSILVSSRKMWDPDAYPNPELFNPYRFLRLRETPGHET
SAQLVWPSPDLGFGYGKHACPGRFFTANEVKIALCHIILKYNFNLPDGYTPTVRKRGIS
LSADPSAKLVIRRRQEEIAL*
>CYP68L6 Aspergillus terreus
63% to CYP68L3
ATEG_03869.1
MLDTVTELPRWDLISLIGLSVISTLFFLLSPFQRSPFPLINGKGTLELSSSNAKKRFLADAGNLIKIGLSKASVIRLVSD
NDVKTVLHPKYVNDIRSHPALSFGTAIQKEFHADAGIHGFEPFKQGSTAGEIFQYAVRTKLTQSL
(1)
GNVTEPLSSETALTLDTSWTSNT (1)
EWHEVDLRASILGIV
AQLSSRVFLGDQICRNPDWLRITVNYTVDSFIAAQDLRLWPKPLRPLVANFLPSCRKIRSELREATEIITPVLEERRKSK
ETQVREGRTPERYVDAMQWMEESAEGRPYDPAVAQLSFSLAAIHTTSDMLTQALLDLCGKDDLIKELREEIVTVIQGEGW
KKTTLYKLKLMDSVLKESQRLKPVSIASMRRLASEDVKLSDGTIIPKGSSLFVSSDNMWDPSVYPDPEKFDPYRFLRLRE
IPGHETSAQLVSPSPEHMGFGFGKHACPGRFFAVNEIKIALCHILLKYDIRLPEGYTPAKRRMGISLDVDPLARLLVKRR
QEEILL
>CYP68L7 Aspergillus terreus
54% to CYP68L6
ATEG_10083.1
MLEPVSTAQSLWSFGLWILVILSPVLFFASRELGILNAKKRFAKNGFEEVLAGLRKSDVFGLMTINGPKIVLAPKFAQEI
RSNPALSVSAFSSSELHAHIRGFDVFRQGEADDILQDTVRSKITQSIGDLIQPLSEECSLTLKPKWTDSPEWHEVCPHTT
ILDIIARLSSRAFIGDELCRNPKWLRLTVDFTVDSFRAAEALNWWPYALRPLVARFLPSCLKLHKYIQDADNMMKPVLES
RRQAQAKDPQKSYPDTIQWFEETAQGRPYDPVRLQLTLAFASIHTTADLVIQTILDLCSAKNWDELCRSLREEIISSFRE
EGWRKPLLAKLKIMDSALKESQRLKPVSIVGMGRIAKEAVKLSNNTIIPKGTRLLVSNTAMWDPEIYPDPRTYDPYRFLR
LREASENESAGQLVSLSPTHLSFGLGKHACPGRFFAAAEVKIILCHILLKYDIKLADGCKPKPLRAGTNLVADPTAKLLV
RRRQEEVAL*
>CYP68M1X Aspergillus nidulans
Name revised
to CYP5073A1
>CYP68N1 Nectria haematococca
e_gw1.41.77.1
Necha1/scaffold_41:90805-92550
52% to 68D1 N. crassa, 48% to e_gw1.16.35.1,
48% to 68A1
This gene model seems correct
MLWAELLPRLDAIGKPLPLIVTIAVILFVYHAFQPFRSNVPILNGRKGLELTNQRPKKEYVSQATKLVGD
WFNSNPNKPVRLISDVEEITVLPPSLAQEIRSDKRLSFSQWTFK (0)
SFHGNLPGFDGFAAGTGGTNLVQTVVTKDLTKFL (1)
SKVTEPLAEETSLSLEELFTNETGGSSP (1)
EWHDIPMRDKVLRLVARISSRVFLGPELCRNENW
LRITRDYTVTGFFAGEDLRMWPEFVRPLVHWFLPGCRKLRADVKEARSMINSVVEERRKRNQELTAAGQD
IPDYNDAIAWFDKAAKGATYDRAAMQLSLSLAAIHTTTDLLTQVLTRISQNLEILKPLREEMISVLREEG
WNKTSLYKMKLLDSVIKESQRMKPTEI (1)
VSMMRLALDDVKLSDGTVIPKNTGVAVSSHRMWDPSLHPNPHQ
WDGTRFYKMRDDPAKQNSSQLVSTSPDYLAFGHGQNACPGRFFASNEVKIALIQIILKYDFELKEGASPQ
IYKHGFTLTGDPFLELRIRRRKEEVPL*
>CYP68N2P pseudogene Nectria haematococca
fgenesh1_pg.scaffold_36000012
Necha1/scaffold_36:51153-51671
48% to 68J2 C-term only, 64% to e_gw1.41.77.1
remove last exon from model, add cyan
(1)
VSMNRLALADVELSDGIFVPKDSSLTVLSHKMWDPKVYANPDQWDGYRFLKMREDPEKQNSALLVSTSPDY
LGLGHGQHACPGRFFASNEAKIAVLSFIIKYDFKLVGEAPPDVIKHGFNLSGDPSTQMRVRRREEEATV*
>CYP68 FRAGMENT Magnaporthe grisea
MG10029.4 AACU01001319 cont2.1919
62% to CYP68A1 C-TERM fragment RUNS OFF END
VACTPTHFGFGHGVHACPGRFFAANEVKIALAHILLKYDWKLA
EGSEKLEPVERGLNYVVNPNIKFLIRRRKEELDLESLEF*
>CYP68P1 Aspergillus fumigatus Af293
GenEMBL
XP_756138.1 also EAL94100.1
41% to 68N1,
39% to 68A1
MDFLQRILGILSSEDVAPALFASSISVLFLILSYQVLYPPSKYSAFPTINGTRWLALSNRRILAEFVTDA
QGLMRNGLEKYDIFRIISSIGPMTILHPKYTDEIHNDRQLNFMAVLAKEMFPNYPGFDLFREGTDGSTVL
QDAVKFGSSRCLGKSTQLLSDETSTLLQKLWGDEPEWHEVTAKSSVHDIIAHLSALLFYGPELCSHKEWL
EVTDEYASVGFLAARQLRLWPPILRPIAQWFLPACRRLRYLASRTRGLIEPVIAARQKEKAICYSHGRQP
PVYDDAIEWTERAAKGRPYDAAMSPLLFSINALHTTTDLLTQVILDLSTQPDLIVALRQEILSVKPQQNG
WKNASLNQLLLMDSAIKESQRLKPTESILMRRYAMDDLTLADGNKIPKGTVLGIPIFGMRDPKIYVDPDM
YDGYRFQKMRDKPGFENKCQLVSTSPWHLGFGHGIHACPGRFLAAVQVKIILCYIVAKYDFKLAGGAPPK
VQSVGIELISDTEARLAVRRRQEMVIGLE
>CYP68Q1 Aspergillus oryzae
GenEMBL
BAE64916.1, AP007171.1
47% TO 68L2, 45%
to 68L1, 48% to 68D1
14 P450 genes and
2 pseudogenes on this contig
MDHFNLAGPESNTSITSLEWLGIKNSFTGSHWAHITGLSELHPTGFLCLIATLIIGIVHLTRGPKPTVLP
VVNPPGTFELTANRVKKEWLVDARQIIRRGFEKFPGKPFNMIAADVGLTTVLPPEYASEIRNNPSLSFVA
FMAHLFFSELPGFEPTREGMFDNDIGITVVHKYLTVNLARITEPLSREATAALKDIFTDNSEWHDANLKA
INLALVARLSSRIFLGEELCRNEEWLKITVNYTVDVMKAAERLRRVPGPLRRIVHWFLPEAQKCRDEVKR
AGKVIRPVLEKRRREKATMESEGKEALQYNDAIEWFEQMAKSQGTSYDPEVVQLFLSTVAIHTTSDLLTV
VMADLARNPEIIEPLREEISSVLRDGGWKKTSLTDMKLLDSVLKESLRLKPIAVVSMRRVAMDHLKLSDG
TFLPKGTKMAVSSHRMWDPDVYENPEQWDGFRYVNLRETPGQDKHAQFVSTSERHLGFGHGKHACPGRFF
ASSELKVALCHILMKYDFELAPGTVVQHRYSGASYYADPAIRVMLRRRNVALPSWFER
>CYP68Q2P Aspergillus clavatus
~73% to 68Q1 Aspergillus oryzae
pseudogene adjacent to CYP5117A2P on opposite
strand
ACLA_064150
ISIARITEPLSQESTSALRDIFTNDPD ()
LAAQGKEAVPFDDAIEWFEQMAWSKNITYDPEIVQLFLSTVAIYTTSDLLTVTLLDFARN
PEIIEPLREEITAALEHGGWRKTSLTEMKLLDSVLKESLRLKPIAV
()
VSMRRVVMDHVKLSDGTVLTKGTKLAVSSHHMWDPSIYKDPEKWNGQRFLHRRDVPGQDK
DAVFVATSERHLGFGHGKNACPGRFFASSELKVVLCHILMKYDIELPPRAVVRHHYSGAS
&
ADPEARLLIRRRSVPLPAGFE
>CYP68R1 Aspergillus terreus
AF141924.1,
XM_001209275.1
lovastatin
biosynthesis gene cluster
gene="lovA"
function="involved in lovastatin production"
39% to 68D1 N.
crassa
73% to CYP68R2 gene mlcC
Penicillium citrinum ML-236B
(compactin)
biosynthetic gene cluster
ATEG_09960.1 4 aa diffs
MTVDALTQPHHLLSLAWNDTQQHGSWFAPLVTTSAGLLCLLLYL
CSSGRRSDLPVFNPKTWWELTTMRAKRDFDANAPSWIESWFSQNDKPIRFIVDSGYCT
ILPSSMADEFRKMKELCMYKFLGTDFHSHLPGFDGFKEVTRDAHLITKVVMNQFQTQA
PKYVKPLANEASGIITDIFGDSNEWHTVPVYNQCLDLVTRTVTFIMVGSKLAHNEEWL
DIAKHHAVTMAIQARQLRLWPVILRPLVHWLEPQGAKLRAQVRRARQLLDPIIQERRA
ERDACRAKGIEPPRYVDSIQWFEDTAKGKWYDAAGAQLAMDFAGIYGTSDLLIGGLVD
IVRHPHLLEPLRDEIRTVIGQGGWTPASLYKLKLLDSCLKESQRVKPVECATMRSYAL
QDVTFSNGTFIPKGELVAVAADRMSNPEVWPEPAKYDPYRYMRLREDPAKAFSAQLEN
TNGDHIGFGWHPRACPGRFFASKEIKMMLAYLLIRYDWKVVPDEPLQYYRHSFSVRIH
PTTKLMMRRRDEDIRLPGSL
>CYP68R2 Penicillium citrinum
BAC20565.1,
AB072893
gene mlcC
compactin biosynthetic gene cluster
join(AB072893.1
:15823..16167,
AB072893.1:16234..16405,AB072893.1:16469..17508)"
note="putative ML-236B biosynthetic gene"
73% to lovA
CYP68R1
note: compactin is
6 desmethyl lovastatin
1 MLGQVLLTVE SYQWVSTPQA LVAVAVLLSL IAYRLRGRQS ELQVYNPKKW WELTTMRARQ
61 DFDTYGPSWI EAWFSKNDKP LRFIVDSGYC TILPSSMADE FRKIKDMCMY
KFLADDFHSH
121 LPGFDGFKEI CQDAHLVNKV VLNQLQTQAP
KYTKPLATLA DATIAKLFGK SEEWQTAPVY
181 SNGLDLVTRT VTLIMVGDKI CHNEEWLDIA KNHAVSVAVQ
ARQLRVWPML LRPLAHWFQP
241 QGRKLRDQVR RARKIIDPEI QRRRAEKAAC
VAKGVQPPQY VDTMQWFEDT ADGRWYDVAG
301 AQLAMDFAGI YASTDLFVGA LVDIARHPDL
IQPLRQEIRT VIGEGGWTPA SLFKLKLLDS
361 CMKETQRIKP VECATMRSTA LRDITLSNGL
FIPKGELAAV AADRMNNPDV WENPENYDPY
421 RFMRMREDPD KAFTAQLENT NGDHIGFGWN
PRACPGRFFA SKEIKILLAH ILIQYDVKPV
481 PGDDDKYYRH AFSVRMHPTT KLMVRRRNED IPLPHDRC
>CYP68R3 Monascus pilosus
DQ176595.1,
ABA02241.1
monacolin K
(lovastatin) biosynthetic gene cluster
possible GC
boundary at exon 2/3 DNKggc
86% to lovA
CYP68R1
41447
MTVPTDTVSRRLQSLAWSDIKQHAPWLPSSRTLVSGFLCLILLQILYSRGRKSDLRVYNP 41626
41627
KKWWELTTMRAKREFDANAPAWIEAWFSKNDQPLRFIVDSGYCTILPSSMADEFRKMKEL 41806
41807
CMYKFLGT (0) 41830
41908
DFHSHLPGFDGFKEVTRDAHLITKVVMNQFQTQAAKYTKPLADEASATIADIFGDNK (1) 42078
42144
EWHTAPVYNECLDLVTRTVTFIMVGDKLAHNEEWLDIAKHHAVTMAIQARQLRLWPVILR 42323
42324
PIVHWLEPQGAKLRAQVRRARQLLEPIIQERRAEKAKCLAQGIEPPRYVDSIQWFEDTAK 42503
42504
GQWYDAAGAQLAMDFAGIYGTSDLMIGGLVDIVRHPHLIEPLRNEIRTVIGEEGWTPASL 42683
42684
YKLKLLDSCLKESQRVKPVECATMRSYALQNVTFSNGTFVPKGELVAVAADRMSNPEVWP 42863
42864
EPKKYDPYRYMRLREDPDKAFSAQLENTNGNHIGFGWHPRACPGRFFASKEIKIMLAFLL 43043
43044
IRYDWKLVPNEPLQYYRHSFSVRIHPATKLMMRRRDEDL* 43163
>CYP68S1 Aspergillus niger
e_gw1.4.292.1|Aspni1
51% to CYP68L2
MELKVDVKEHGNPLSLGTSIFLLSLVLLFVFRWGDTPASQNGLPLINAKRRFEIVDLLAKKRFITNAQELLKAGLEKASV
FNIVTENGVMMVLDPKYADEIRNSKTLSLRKTLIEDMHVNVPGFEQQMQALEDDEIFQTTLKTKLTRNLEDLNEILSQEA
TVALQEHWTNNPEWHEIPLSRSMLKIIAQLSSRVFLGDKICHNPKWLRISVDYSIDLFQATFELRIYPRFLRPLASRFQP
SCRRLRADIREARSIIEPVIEERQLAKAIAKQEGRDPERHEDTIEWLEEVANGRQYNPVSAQLLLSSAAVHTSSDMLTQV
LYDLDGRQELIEALREEIRSVFENGWERSSLAKLRLMDSVLKESQRLKPISSVSMRRMAEAPVTLSDGTLIPKDCKVIVP
CLRQWDEKYYPDPETFIPDRFLKLRNEPGYEHTAAFANSSPNHLGFGLGRHACPGRFFAANEIKLALCHILMKYEFRVVG
KKPEKVVFGTMLAADPNGVIAVRRRK
>CYP68T1 Aspergillus niger
e_gw1.3.1460.1|Aspni1
51% to CYP68L2, 42% to e_gw1.4.292.1
MFAANIISYLAKLVPPRWIWAPILAAVFFWLLSAPSLKTSLPVINQRRRFEIGSLGSLKRFFKDAHGLVRAGLSQGSAFY
LYSEFGPKIVLASKYADDFRSHHALSLLDAVAEEYHAHIRGFDPFNRDPAIIIDMVRMKLTPHLGDLARPLSEETGRALG
ELFTDDPDWHDLELKPNMLDLISRLTSRVFLGEKLYRNPDWHRVTAGYVVHTFMSALFLRMFPRCTRPFVANLLPFCRKM
RKELQEAKDIITPVVEERRTAKQDAIRQGKEPERYVDAMQWMEECAKGRPYDPTLAQISLTLATIHTTSDLLTQTLFYLA
ERDEIIVALRNEVITVLQGDGWSKSTFNNLKLMDSILKESQRLKPHNMDVILSDGTVLPKGSISVLTTEAMRDPTIYPDP
EIFDAYRFLKLRETPGYETMVQAVSTTPQHLAFGLGKHACPGRFFAIALLKIILCHILLEYDFKIADGWSPTVRKYGFIW
QADPVAKVSVRRRKEEFTIL*
>CYP68U1 Mgr025 Mycosphaerella graminicola
47% to CYP68N1 Nectria haematococca, 48% to
CYP68D3 A. Niger N-term from JGI model
fgenesh1_pm.C_chr_10000062|Mycgr3
MIILALAAVAVHWSDRSSN
PLLNAKGFFELSDRRIKIAFLGNARPMLSDWFGKHQNSPVSIYSDTGVLMVLPGSMANEIRNDKRFHLRQQVERMMHGRLPGFEQLGKRTVHIVSRNISLTQREAKVTTPLVDEISVAVSELFGSNSDWHELTIQTTILELVARTSSRVFLGAELCHNPEWLKVSKEYAVLAFLAAQDLRLWSPWLRPIASLFLSKCRLSRAAIHKARATIEPVLAERSKLVAKNTGGKATVFDDAIAWIECAAGTASYDPQIVQLSLSAVAVHTTTDLLSQALADIAAHPEIIAPLREEMISIMNQDGVLQTASLGRMELLDSCIKESQRMKPLSIASMGRIATERVTLSNGTVIPKGQSILVDSSRMWDAKVHPSSPKTWDGYRFLRMREDPMKRDMAPLVSTSPDHIAFGYGVHACPGRFFAANEVKIALIYILLKYELRFEEGQMPRAFDHGFTCVSDPSLKLSVRRRTEATVL
>CYP68V1 Histoplasma capsulatum G217B
50% to CYP68N1
HCB01530.1
MATLEPTTSYIAELISTSNLPSITFVVTALTLAVFYILQRRKSTVPLINPKRWFEFSDYRIKQEFVHNAIPLVKKGFAAT
GNKPFRILADSGEVTVLPPDVANEIKSNDRMSFELNTAKHFFGHLPGFEVFNATGQNMKVSKSIVQRQLTTHLNKVTKPL
SDEASLSLQEILTDNKEWHEITLKNELLQIIARISSKVFTGDELCHDKTWLDITVNYTIMAFAAADSLRMWPPYLRSIVH
WFLPKCRASRAEVVRARTVIEPILKRRAEQKAALAAQGKKAPEINDAIEWFTSATTIEGFTLDPVIAQLGLSLAAIHTTG
DLSTQVILDIASHPEIIEPLRKEMIESLSEGGWKKNSLYKLKLLDSVIKESQRMKPIASISMNRLTTTNVTLSDGTFIPR
NTATAVSSHRMWDPSVHTNPDQWDGYRFYNKRQEPGQENLSQLVSTSPDHLAFGHGQHACPGRFFAANEIKVLLCHLLLK
YDLKIVEGSMIKPFPYSFSMNANPFAPLMIRRREDVIDLDALDA
>CYP68W1 Aspergillus clavatus
42% to 68D1
ACLA_055740 removed small intron
MFRENLGPIFLTALPAILLSYFLSVALPSLRLQWKTSHIPIINKKKGEWSDSNAVKRCAHNAQAILQEGHEK
(0)
YTGPFQLIGSFGRRIVLPPELGEHVKTDPRFTASEVVRQTMAGSLPGFEGLLPVMEAGAPNVFIQMIRS
KLTSNLGKFTQHLAEETQAAFDEKWGTSTEWHEVDLLASLRDIVTQVSTRIFLGPELCKNKEWLDNTQAYTDNVFKAVRS
IRRFPAWSRPYVQWFLKDCSRIRQQVKRAEEIIEPIIAKRLEEIALAQKGLAEMPNDAITWMHQVAQGKGKDYHGAHIQL
SLSMASVHTTSDLFSNILLQLCRHPEWIEPLLQEAQSVRSEGGWEKTSLYRMKLADSVMKETQRIKPLGVLLSHRHVSDD
VILPDGTLIPKGAIVATNMSRMWDPEFYPNPEEWQPDRYLKRREEPGKEHSSQFVTTTMESLGFGIGSHACPGRFFASSK
IKLLLNHVLQNYEFERVDTGKDATPFFVEYVTNPKAKLRVRRKEISS*
>CYP68X1 Neosartorya fischeri
47% to CYP68V1 Histoplasma capsulatum
NFIA_098910 revised
Note: this seq does not have an ortholog in A.
fumigatus
MAVQEIITILLKHIHSAGL
MAWLLLVLFVGSVMLTIRKSLSTNGA
SHIPLIDPRKSYDIGGIYAKIDFILHARRLLALGVSSGRPFRLLTDLGEMIVLPACFAAEIRSDHRLSFAE
(0)
NFHSRFPGFEGFRMGTTDALLSRDIANNQLTHTL (1)
AKVTQALSDECAAALNDHFPAKE (1)
ENRMPEWSDICLREHVLQLVARLSSRVFLGDEGANNRAWLR
ITTEYTKTAYIAAYMLRLWPPFLRPFAHWFLPHCQKLRGQVAEARRIITGVIERRRESIAAAELAGQQIPQYNDAIEWFE
QDVAKQDGRYDPVVAQLILAQAAIETTTDLLTQVILDLAQHPELADPLREEVTKIIREGGWRKSSLYEMKLLDSVLKESQ
RLKPLAMTSMHRLVLEDITLSDGTRLPKGSVIGVSVDRMWDPSVHENPTQFDGFRFQRMRDHPGGTANQAHLVSTSVNHL
AFGHGKHACAGRFFVAHETKIALTHLLLKYDWRIASSSIDARPMEFGLVLQANPKAKISIRARQPDSEGPIRA*
>CYP69A1
Gibberella fujikuroi P450III gene Y15279
MKYTTCQMNIFPSLWSMKTSFRWPRTSKWSSVSLYDMMLRTVAL
LSGRAFVGLPLCRDEGWLQASIGYTVQCVSIRDQLFTWSPVLRPIIGPFLPSVRSVRR
HLRFAAEIMAPLISQALQDEKQHRADTLLADQTEGRGTFISWLLRHLPEELRTPEQVG
LDQMLVSFAAIHTTTMALTKVVWELVKRPEYIEPLRTEMQDVFGPDAVSPDICINKEA
LSRLHKLDSFIREVQRWCPSTFVTPSRRVMKSMTLSNGIKLQRGTSIAFPAHAIHMSE
ETPTFSPDFSSDFENPSPRIFDGFRYLNLRSIKGQGSQHQAATTGPDYLIFNHGKHAC
PGRFFAISEIKMILIELLAKYDFRLEDGKPGPELMRVGTETRLDTKAGLEMRRR
>CYP501A1v1 Candida albicans
GenEMBL XM_706447, orf19_1411
allele of CaO19.8987 XM_706426.1 (5 aa diffs)
best hits are to CYP504, but only low 30% range
in CYP64 clan
putative phenylacetate hydroxylase
MLSSIRWDEALLILLNYLNDYPVTITCFLVLLIIALGIAIDYII
TPKEIANIFPIPGELPFIGHLHLILENPALIYLTWSKLYNQSIFQIRIGNKRVVVVNS
FDDVVGLWVNHSCQNNSRPLSYTFHDLVSAIQGFTIGSTPASLTFQKKKKTISQYLNK
RQIELKSDTINRQINIMIGELWKRDIEFEDINLLPYFQKFVLQTAIFIGYGIELDCYK
EHSQFCQEIIDIENKIIRLRSPISNLQDSIPLLRIMPRWFNNSEIARMCGERRNSYMN
KLYQQLQQGLAEDLPQYKNSILGDLITKTTNTQNNNDDSSDTNCTSHNNCLNEQEIQS
ICLTLISAGLDNTPLSLNYLFGILSHPKIGEHLQNRAIQDILEDSGGNIVLAWEKVSS
LQGQMTTNQQNPMNCQYIEALVLETLRHFTVLPLSLPRLTTKAIRYKDFVIPKETHLF
MNAYSANHDCQIFVNPYKFDPDRWLDPVSNSIKSQFLNFIINNNSKSSSGHGHQFKSL
HSHQHFAFGAGSRMCSGYNLVIKQMYVMIIKMLLIFEIHPPTNIKKLMELNPFKNNSN
PKGTSFEPKTNHINLKFRKLPNYKSLHELVLHQS
>CYP501A1v2 Candida albicans
GenEMBL XM_706426.1
allele of CaO19.1411 XM_706447 (5 aa diffs)
Gene sequence has no introns AACQ01000193.1, AACQ01000194.1
best hits are to CYP504, but only low 30% range
in CYP64 clan
putative phenylacetate hydroxylase
MLSSIRWDEALLILLNYLNDYPVTITCFLVLLIIALGIAIDYII
TPKEIANIFPIPGELPFIGHLHLILENPALIYLTWSKLYNQSIFQIRIGNKRVVVVNS
FDDVVGLWVNHSCQNNSRPLSYTFHDLVSAIQGFTIGSTPASLTFQKKKKTISQYLNK
RQIELKSDTINRQINIMIGELWKRDIEFEDINLLPYFQKFVLQTAIFIGYGIELDCYK
EHSQFCQEIIDIENKIIRLRSPISNLQDSIPLLRIMPRWFNNSEIARMCGERRNSYMN
KLYQQLQQGLAEDLPQYKNSILGDLITKTTNTQNNNDDSSDTNCTSHNNCLNEQEIQS
ICLTLISAGLDNTPLSLNYLFGILSHPKIGEHLQNRAIQDILEDSGGNIVLAWEKVSS
LQGQMTTNQQNPMNCQYIEALVLETLRHFTVLPLSLPRLTTKAIRYKDFVIPKETHLF
MNAYSANHDCQIFVNPYKFDPDRWLDPVSNSIKSQFLNFIINNNSKSSSGHGHQFKSL
HSHQHFAFGAGSRMCSGYNLVIKQMYVMIIKMLLIFEIHPPTNIKKLMELNPFKNNSN
PKGTSFEPKTNHINLKFRKLPNYKSLHELVLHQS
>CYP501A2 Candida tropicalis MYA-3404 cont1.80
GenEMBL AAFN01000033.1
62% to
501A1 in CYP64 clan
putative phenylacetate hydroxylase
128977
MLLSIPWDQSLLTLLTYLDTHPIATIFTIILTILTIGILFDYCLSPKEIANIFSIPGDLP 128798
128797
FIGHLHLILDNPALIYLTWYKLYNKLVFQIRIGNKRVVVVNSFDDVVGLWINHSCQNNSR 128618
128617
PLSYTFHGLVSALQGFTVGSTPASLTFLRKKKVISLCLRKKEIDEKVCLIDNEICVMIKE 128438
128437
IIKKKDISTDVNMLPYLQKFILKTAILMSYGIELDCYNKDVKLCQEIITVENNIIRLRSP 128258
128257
ISNLQDSVPFLRLIPWFNNREFALRCGNRRNKYMDQLYNRLQNGLAENDPNIANSILGQ 128081
128080
LILNNDNNNSNSLTSQEIQSICLTLVSAGLDNTPLNLNYLIGILSQ 127943
127942
PRIGKIFQDKAIKDILNHANGDIIQAWNQLNEENRDCKYIQALILETLRH 127793
127792
FTVLPLSLPRLTTKPIYYKNFMIPKNTHMFMNAYSANHDELIFKNPFKFDPERWLDSETN 127613
127612
EIKSKILATTSSSSSSTHHGGGNGINVQNFHFAFGAGSRMCSGYNLVMKEMYMMIIKL 127439
127438
LLLFEINPPDNNNNNGKYLMEMNPFVNNLNPRGTSFEPRIHNIKLQYRKLPNYETLHEIVLK* 127250
>CYP501A3 Candida dublinensis
89% to CYP501A1v1 Candida albicans
cdub_11-g248.1
VSNNIKSQFLNYIINNNSNRSNHGRGQ this seq may bw an
intron (too long) remove it
MLLSIRWDEALLILLNYLNDYPVTITCFLILLTIVFGIVIDYTITPKEIANIFSIPGELPFIGHLHLILENPALIYLTWS
KLYNQSVFQIRIGNKRVVVVNSFDDVVGLWINHSCQNNSRPLSYTFHDLVSAIQGFTIGSTPASSTFQKKKKTISQYLNK
RQIELKLDIINRQINIMIGELWKRDIEFEDINLLPYFQKFVLQTAIFIGYGIELDCYKEHNQFCQEIIDIENKIIRLRSP
ISNLQDSIPLLRIMPRWFNNSEIARICGEKRNIYMNKLYQQLQQGLADDLPQYKNSILGDLITKTKNRNDNGESGGMNCI
SRNNCLNEQEIQSICLTLISAGLDNTPLSLNYLFGILSHPKLGERLQTRAIKDILENSGGNAILAWEKVLLLQALVTTNQ
KNLMNCQYIEALIMETLRHFTVLPLSLPRLTSKEIRYKNFVIPKETHLFMNAYSANHDCQIFVNPYKFDPDRWLDP
FKSHHNHQHFAFGAGSRMCSGYNLVIKQMYVMVIKMLLIFEIHPPTNTKKLMELNPF
INNLNPKGTSFEPKTNQINLKFRKLPNYKSLHELILQQD
>CYP501A4 Candida parapsilosis
50% to CYP501A2
Candida tropicalis
CPAG_01739
MPWTTVDGILLYIHSIARSPLTRWTCFVSVALLMIAIVYDYIYKPSKIKGIYPIPGELPIIGHLRLLRNNPSQVFLVWAT
RYDKSVFQIRLGNKRVIVVNDYDDVVELWMNHSCQNNSRPLSYTFHGLISSYQSFTVGSTPQSTTYKRKKRAIAQFLNSK
SISSYSLSICREIELTLFRLENVAINVDVDVCHYLKYFVLRCSVFLMYGLHLDCFGVDNALCNEIISNESEIIRMRSPIA
NVQDSVPLLKYLPNLTNASLAVQCKNKRERYMSELFARFEDKMNLGDCDSIGSFIGQLIAETGNKQLTDAEVYSICLTFI
SAGLDNTPLNLNYLLGILSQPSIGKAYQSKAINEILANCGGDVQKAWEQSNESTLKNVYVHALILETLRQFTVLPLSLPR
TTTKTIIYNGVEIPAGSQLFMNAYAANHDPKHFKCPFEFNPERWIDANGQISFTAKAYQHFSFGAGSRMCSGYSFAVKEM
YIFMVKFLLMFEVHPPDSKLMIADPFLSNENAHATSFEPRSHNIRLTLRRSRNQEWLHDTELVR
>CYP501B1 Candida lusitaniae
38% to CYP501A3 with some indels removed
CLUG_05046.1
MWLALLLLVALLFFLPPPRPIVGAFYVPGYPLVGNACQVLHNPSRVFLSWAQTCGHALFVIHLGRTPVLVVNSHADVHDL
WLLHSSALGSRPTLHTFHNVVSAVHGLTVGSTPAGASYRRKKKTLSSELSASRVQSKV
LSGNAQRALLSPNLSSVPKSSSIDSGHESGFPPILSHIDVCSSECIAQLLSHPA
ETSLLLETQYFVLSAAIRLTYGIVLDCHGRDASLANTIIATENKIIRM
RSLVANYQDYIPGLQSFPLRCMFDARAAKWRQQRDSYMHSLYQSFLVQLHGGSFLANHSMLAHILRAKASPMTLSESELQ
SICLTMVSAGLDNSALTFDHLMGHFSHDYGQDMQERLWKELMLQSNGSLATAWDAATYGTCSYAMALLHEALRFFSVLPL
GLPRQTTKPVRFRGLYIPANTIVVMNNYAANHDPAAFESPFEFSPDRWLDP
NGNLITPNHFSFGAGSRKCAGSHLALKEL
HTLLCRMVLLFRIKPPQDARFKMCLDPFEGNSCPTGTSFEPKEFRVRLEPREGKECDELRDRLRDYRIPQERAK
>CYP501C1 Candida guilliermondii
43% to CYP501A2, yellow is long
PGUG_01534.1
MSSLWYLVTDCILLFIFAWIIEDCILALGVEPPIPGIKQIPSYPIVGNLLQVKNNPAKVYLKWSKFYKVPVFQVRLGFRN
IVVANSYQSVEFLWGKSASANNSRPTSHIFHNIVSQSQGFTIGSTPASSSLFKTKQALSSELNRKSVNMIAEQLDQQVKY
TLRMIIRNNVELK
GSPSTFLSHVRSRLS
DIDLLPYFQLFALRSAIQLTYGITLDCYGKHGRISQEIIEVENQIIKLRGQG
SWLPDFLPFLKYFGNWELSASKYRLRRDNYMNELSRDFKKRYSNNDAAARTSLLGRLYKNSSHLAHHELNSICLTMVSAG
LDNTPLTINHLMGHLSRPDYGYALQQVAFSQLLNCYGDINDAWNNCGTNMECNFVVALVQEALRFFTVLPLSLPRKTTKV
IKFNGVVIPEGAVLYMNAYAANHDSEKFSNPMKFDPFRWLVPRTMKLKDRREMDHFAFGAGSRKCSGNILATQEMYSMIC
RLILIFRIRRPIEEAMELDPFESNACPSATSFEPKRFKVHLEPRCHEGSEVLYRSLQ
>CYP501D1 Debaryomyces hansenii
45% to CYP501A2 Candida tropicalis
CAG86740.1
MVFATMGSAIFDFIRLLITFWNYKILNLLNIIFAIFLLSIFMDLVLGIGVPLKIKGIFAIPGYPIVGNLFQVLNNPALVY
IQWANKYNASIFQIRLGFKRIIVVNSFEDVNILWTKHSCSNNSRPVQYIFHGIVSATQGFTVGSTPSGPSYKRKKKVISQ
SLNQKSVNNLSSVIDNETKFTIKNIIQNNRELFGPPSCNNYRYTRTIISDIDLLCYAQLYSLRSAIFLTYGLHLDVYDSE
ADLAKEIIEVESNIMKFRAPVSNLQDYIPILRYLPFGKSMQAQHYRNRRDAYMNKLFQQLQEKILEGDVDSSNSLVGVAI
KNMELTLKLTSAELQSICLTMVSAGLDNTSLNFNHLMGQLSQPTTGYIYQRKAFEEMMSRNKNNICTAWDNAAIVMDCSY
VIALIKETLRYFTVLPLGLPRITTKDITYKDAIIPKNSILFMNSYAANHDPNIYKDPMRFIPERWLDLITGLVLSKYEIS
HFSFGAGSRMCSGNHLAFKELYTLTCRMILTFQIRRPTSNKFLMELDPFKNNSNPNAISFEPKLFKVRLEPRIHNRSDDL
YNKILRS
>CYP501D2 Pichia stipitis
56% to CYP501D1 Debaryomyces hansenii
JGI model e_gwh1.7.1.272.1
ILGVFKIPGYPIVGNLFQVINNPAQVFMKWSEVFNVSLFQIRFGSRSVVVVNSFEDVTRLWIKYSCSNNSRPVLYTFHQV
VSLTRGFTVGSTPAGESYKRKRKSISQHLNHRAVERSKSTLDKEVEYMINQMISRNHELSGPPSVNMFRNSKCELADIDM
KIYFQQFALRSSVFFAFGIHLDCFGKDSKLCNEIIEVESAIMKFRSPIANLEDFLPILRYFPGKFKKAAEFRERRDRYMN
KLYKTMIEGIVVGNADAVASIVGTIKIEQDQQMNKLTEEEIQSICLTLVSAGLDNTALNINHLMGHFSQPFYGAALQKKA
YDALLAGSNGDICQAWDDAVDVKCPYVIALVQESLRYFTVLPLGLPRITTKDIVYNGAFIPKETILIMNAFAANHDSCVF
QSPYEFIPERWLDAETGELIDKHDLIHLSFGAGSRMCAGIQLAINEMYTFTSRLVLYFKIKPPTCGAIMDLDPFRNNENP
SATSFEPKPFKVRLEPRYSDSLYNKLRRS
>CYP502A1
Coprinus cinereus AB013443
MTTTSSSIFAGLGCLLVASIIYFRKFKANPARAHLPPGPKPIPV
LGNVKDLRAKELWLPAMDWAKQYGDITYLHVFGQGLTFINSLESASDLLEKRGGMYAD
KPQFTMVCELCNCKNMVAFTPYGEQSKRQRRLMHKAFAPARIPDYHPLMESSTNLFLR
NVIASPADYIGHVRRYSGSLTLNIVYGYEVTSNEDEYLMMAEECVGILANEIASAGGV
WAVDVMPFLAKIPKWAEGLPGMSFKRKARKWKKMMEDWVDGPFEYVKNTMKSGTYKQS
FCSSLLDDESISQTQEHFEFDLKWTANSMYAASIDTTITSVAHFLLAMMKHPEVLKKA
QHEIDTVVGQDRLPTFSDRKSLPYVEAVLSETWRWASPVPLSLPHKLTEDDVYRGMYI
PKGSLIFANIWAMTRDERIFPDPETFNPERYLNMDPETKKKQDPRNFIFGFGRRLCPG
NHIVDASLWLLVVRMMATLDISTPVDEKGNAIDIVPVFDNPIFRTPNPFPCDMRPRSE
KAVNLIRQYADPRASA
>CYP502B1 pc.5.187.1 Phanerochaete chrysosporium
MDTVLVGLFVALALYAWSRSSKRSALPVPPGPKPVPLLGNIFDLTAKELWLRVTGWSKQYDIVYIHLLGQGLVFCNTYEVAQDLLEKKGSIYSDKCGCQNMVAFTRYGDFARRQRKLMNTAFGISAVKRYRPLLANESVLLLKRILADPQDYMGYIRRYAGGLTLQSVYGYRVETNDDPLLELGTECVDILSNKIASGGGIWPVDIFPFLQHLPTWFPGAGFKRKAAVWRAKMEEFVDKPYEMVLERMRSGATVPCFVTTLLEEARDEKGGAVDAQRDFDIRWTANSMYSASMDTTITVVQLFLLAMILHPEVLRKAQAELDAVVGPARLPTFADRPALPYLDAVMSEVLRWGVPVPLGLPHRLMEDDVYRGTHLRAGTLVFANIWNMLRNEAIWAQPDVFRPERFLEPVDEATAKRRDPRPYVFGFGRRRCPGLHLIEESLWIVMATLLATTDILAEKDESGKPVMPHVDFTNSLVVPFSTPAPFKCDIRPRSEQALQLVRLAE
>CYP503A1
Gibberella fujikuroi Y17243
MSKSNSMNSTSHETLFQQLVLGLDRMPLMDVHWLIYVAFGAWLC
SYVIHVLSSSSTVKVPVVGYRSVFEPTWLLRLRFVWEGGSIIGQGYNKFKDSIFQVRK
LGTDIVIIPPNYIDEVRKLSQDKTRSVEPFINDFAGQYTRGMVFLQSDLQNRVIQQRL
TPKLVSLTKVMKEELDYALTKEMPDMKNDEWVEVDISSIMVRLISRISARVFLGPEHC
RNQEWLTTTAEYSESLFITGFILRVVPHILRPFIAPLLPSYRTLLRNVSSGRRVIGDI
IRSQQGDGNEDILSWMRDAATGEEKQIDNIAQRMLILSLASIHTTAMTMTHAMYDLCA
CPEYIEPLRDEVKSVVGASGWDKTALNRFHKLDSFLKESQRFNPVFLLTFNRIYHQSM
TLSDGTNIPSGTRIAVPSHAMLQDSAHVPGPTPPTEFDGFRYSKIRSDSNYAQKYLFS
MTDSSNMAFGYGKYACPGRFYASNEMKLTLAILLLQFEFKLPDGKGRPRNITIDSDMI
PDPRARLCVRKRSLRDE
>CYP503A1 Gibberella proliferatum (teleomorph sexual form)
MNKSNSMNNTSLERLFQQLVLGLDGIPLMDVHWLIYVAFGAWLC
SYVIHVLSSSSTVKVPVVGYRSVFEPTWLLRLRFVWEGGSIIGQGYNKFKDSIFQVRK
LGTDIVIIPPNFIDEVRKLSQDKTRSVEPFINDFAGQYTRGMVFLQSDLQNRVIQQRL
TPKLVSLTKVMKEELDYALTKEIPDMKDDEWVEVDISSIMVRLISRISARVFLGPEHC
RNQEWLTNTAEYSESLFITGFILRVVPHILRPFIAPLLPSYRTLLRNVSSGRRVIGDI
IRSQQGDGNEDILSWMRDAATGEEKQIDNIAQRMLILSLASIHTTAMTMTHAMYDLCA
RPEYIEPLRDEVKGVVDASGWDKTALNRLHRLDSFLKESQRFNPVFLLTFNRIYHQSM
TLSDGTNLPSGTRIAVPSHAMLQDSAHVPGPTPPTEFDGFRYSKIRSDSNYAQKYLFS
MTDSSNMAFGYGKYACPGRFYASNEMKLTLAILLLQFEFKLPDGKGRPRNITIDSDMI
PDPRARLCVRKRSLRDE
>CYP503A2 Aspergillus niger
e_gw1.4.275.1|Aspni1
54% to CYP503A1
MNKAETPSDSFSELHLIAAIGLSPALVGLLLGIYSLWYLVGPALKQHNTSNQPPIVGCRSRWEPTWLVRLRFIRGSRKII
GEGYERFKDTMFQVRRVGTDVLLVSSKYMDEIRTLTRDATGSVPPLVQDYPGEYTHGMPFLRSDLQNRVLQQKLTPNLPS
LVPVMVEELEFAMRMEMPECAADDWTTVDIMPILSRIITRITSRIFLGPKEGRNEEWLVATVEYTRNFFLTGMALRFFPR
FLRPLVAPLLPSYHHLWQNVATSRRIVGEIVRERREIEAAKPADYTKPADILQWMMDAATGQEAEPGDLAQRMLILSVTS
IHTTTLTMTQAIYDLCAHPQYLEPLRAEVEDVLCTDGGWGKLTVNHLRKMDSLLKESQRFNPVFLLTFNRILPKSITLSN
GVSIPVGSRIAVPSNAMLNDPSRVPGDAPTSFDAFRYSRLREEPENAQRHLFVMTDHNNLAFGYGKFACPGRFYAANEMK
MMLAHMLICYDMRFPDGRGRPRNFTIDSDMYPDPATRLLIRKR
>CYP503B1 Aspergillus nidulans AN1598.1 45%
to 503A1 in 54 clan
revised 7/18/07
MDNYTWHSGTLIPSDSPSSIDRSQLYLEILGVLSVVYLLQT
LVAYSKSFKAPFVGFRFWYEPKWLVGLRFSQGALAQVNEGYAKYKNAMFK
VARNDSDILVIPNKYVEELRSLPDEKISAIRAHIKNLLGKYSTTLILLES
DLHTRMLQTKLTPNLGSFIEVIESELLFAMDQEIPANLDDWQSVNVFHIV
LRIVARISARVFLGVPACRNEEWLQTSIHYTENVFATVMLLRRFPKWMHP
IVGHLLPSYWAIHRNLRTAKRIISPMVRQRRAEEAKRNPDYVKPNDLLQW
MMDGANENDGQPDKLAHRQLLLSLASIHTTTMAAAHCFYDLCQHPEYFEP
LREEINDVIAQDGGWKKTTLNKMRKLDSFLKESQRINPPSLLAFNRIVSE
DLTLSDGTLLPKGTHFSMPSAAILQDNGVEPGADQFDGFRYYKKRLNPEE
ANKHQFAMTDNNNLHFGHGKYSCPGRFFASNEIKIIMAHLLTDYEFKYPR
GATRPRNLTADENLYPDPSARLLMRRRVVAPPQASITPQLVSA*
>CYP503B2 Uncinocarpus reesii
54% to CYP503B1
UREG_02869.1
MPLFENTLLRNMQSTLNDTWLKLSCQKPAVFVFGVTVFLSWQLVNRIFFSVKAPYAGYESSWEPIWLISRRCSHEAPRLI
QEGYRRYRDAMFKIAKRNSDLLVIPKKFVEELRSLPEEQICAMEAHIRTLLGPITGTDILLNGHLHNKALQTRLTPNLGS
LVQPLKDELDYAISVELPNCKDEWVEVQMHGIVRRLVARLSARAFTGPVACRDEDWVMTNTMYPANVFTTIGPLRLFPSF
MRSTVALFLPSYWQLRSNFATANRVLVPIILQRRRDEASGDLNYEKPKDLLQWLMDLAEPNEAAPHLLAHRQLALSLGSL
NTTTTAAVQTLYDICDHPEYLESLRTEVLGALTADGGWDRTTITKLVGLDSFMKESQRVNPPSYVSFNRVVRKSLTLSDG
TRLPKGTHFGMASYSILQDPAIIENPHEFDGFRYKRIREDPKEANKHQFASTDSNNIHFGHGKYACPGRFFASQIVKMII
GHLILKFDFKFPEGQGRPRNLSIDENVYPDPSARLMMRRRQMVY
>CYP503B3 Coccidioides immitis
74% to CYP503B2 Uncinocarpus reesii
CIMG_03089.2
MFSLDPVFLNNAHILFHNAL
FTLSSNKPAIFVISAAVLLLWRLLKDILFSVKAPYVGYESSWEPTWLISRRFSREAPGLIEYGYQR
(0)
YRDSIYKLSRRDSDILVIPHKFVDELRSLPEEHICA
MEAHIQTLLGPITGTDILLDGDLHTKVLQTKLTPNLGHLIGPLKEELEFAMSMELPDCKDEWVEIQMHGIIRRFVARLSA
RAFTGPIACRNEEWVAANTAYPTNIFTTIGPLRMFPSFMRSSVAPFLSSYWRIRSNIATAKRVIVPIINQRRRDEASGDP
NYEKPKDLLQWMLDTAKPKDAAPASLAHRLLALSLGSLNTTTTAAVQTLYDICNHPEYFEPLREELLDSLTANGGWDKAT
LSKLHGFDSFMKESQRVNPPSYLSFNRVVRKPLTLSDGTRFPKGTHFGMPAYSILQDPSIVENPTEFDGFRYKKIRQQPK
EANKHQYASTDSNNIHFGHGKYACPGRFYASHVVKLIVGHLILEYDFKFPEGKCRPQN
LNIDENVYPDPSATLLIRRRQMA
>CYP503B4 Neosartorya fischeri
92% to CYP503B1
A. nidulans
NFIA_009830
Note: this seq does not have an ortholog in A.
fumigatus
MDNYTLLSLHTGNLKPPDSSSSIDRSQLYLGVIGVLSVIYLLQTLVACTKSFKAPFVGFRSSFEPKWLVGLRFSQGALAQ
VNEGYEKYKNAMFKIARNDSDILVIPNKYVEELRSLPDEKISAIRAHIKNLLGKYSTTLILLESDLHTRMLQTKLTPNLG
SFIEVIESELHFAMEKEIPADLHDWQNVNVFHIVLRIVARISARVFLGVPACRNEEWLQTSIHYTENVFATVMLLRRFPK
WMHPIVGHLLPSYWAIHSNLRTAKRIISPMVRQRRAEEAKGDPTYEKPNDLLQWMMDGANENDGQPDKLAHRQLLLSLAS
IHTTTMAAAHCFYDLCQHPEYFEPLREEINDVIAQDGGWKKTTLNKMRKLDSFLKESQRINPPSLLAFNRIVSEDLTLSD
GTLLPKGTHFSMPSAAILQDNAVEPDADQFDAFRYYKKRLNPEEANKHQFAMTDNNNLHFGHGKYSCPGRFFASNEIKII
MAHLLTDYEFKYPPGASRPRNLTADENLYPDPSARLLMRRRMVAEGQAQITPEIVLV*
>CYP503C1 Aspergillus niger
e_gw1.10.655.1|Aspni1
42% to CYP503B1
MVNDTELWTLVTTAHPLPVESIHWTYTLLFLAVGAYCCSIFWSQIFGYKLPIFGTKSPWEPVIISNFRFFHHAEQVLQQG
YNECKNRIFQFRRADTDMLVLPPKYVDEIRRLPNHIASPTLAHVHNLMGSRINMHIILRNNLHFRTLQVKLTPNLNSITL
PMQEEVNYAIEKDFTKSEDEWVTIKPYHTILDLVSRVSARIFLGQPLCRNPQWLELSTQFTENVFVSLVFLRLFPMWTHG
LLTWFMPSSYRGSAYIRQAKKLLVPEINRRRKLASEGIEEPAENKHNLLSWMMEIATPEESDPASLAHLEVVLSLAAIHT
SQMNAVHVLYDLLVHPEYLEPIRDEIRTTILENGPWMTWEKSAFSKLRKLDSFMRESQRVNPPTLLSMHRVLLQEVTLSD
STRLPKGAHISMAVNAIQNDPEVTTNPETFDGFRYYKLRQREGEAHLHQFSTTQDRILNFGHGANACPGRFFAALEIKII
LVRLLMDFEWKLKEPGKRPENLHAHEFIFPNPDAEILMRRRPASECLQL*
>CYP503D1 Mgr045 Mycosphaerella graminicola
51% to CYP503A1, 45% to CYP503B1 yellow is alt N-term from
JGI model e_gw1.1.487.1|Mycgr3
MLHSTNLSTSAVTRYNDSIESALLASVVFILGVACIAAVVRPKSTIGKIPIAGQRSIFEPDWFARLRFIRSSRDIIHDGYSKAGQ
YRDIFIVRKSGTDIVVLCDPKLVDEVRA
QTKEKARSVEPFLHDFVGAYTGGKVFAESDLQNRILMQKVTPNLGAFIPIIEDELQYALDMELPKTDNTGWLEVDMVSAF
PRIVARIIARVLLGPKGCRNEAWLQTTARYTRNVFVTGFVLRFVPRFFRPLIAALLPTYWELLRDLAKARSIIGGLASDR
SSNPQEDVLQWIMDAANVDERKLDDLSQRMLVLSLSGIHTTAMTMVHAIYDLCARADDCSIIRDELSNVLNSGNGINKGT
LLEMHKLDSLIKESQRLNPVFLLTFNRILPCAVFLSNGITLPAGTRVAVPQHAILNDPAKVPGENPHCYDPWRYAKLRED
PDKAHQYQFAMVDSKNMAFGYGKYSCPGRFFVATEIKIILAHLLLKYDWKLPDGRRRPQNFTIDSDMYPDLSARVLIRRR
TDEGPLS
>CYP504A1 Aspergillus nidulans AN8078.1 64
clan
Emericella
nidulans phacA gene, AJ132442
MSLQTIGIAAVAVVYFLIRYFNRTDIPKIKGLPEVPGVPIFGNLIQLGDQ
HATVAQKWAKKFGPVFQVRMGNKRVVFANTFDSVRQLWIKDQSALISRPT
FHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPATQSYMPIIDL
ESMSSIRELLRDSANGTMDINPTAYFQRFALNTSLTLNYGIRIEGNVNDE
LLREIVDVERGVSNFRSTSNQWQDYIPLLRIFPKMNREAEEFRVRRDKYL
TYLLDVLKDRIAKGTDKPCITGNILKDPEAKLNDAEIKSICLTMVSAGLD
TVPGNLIMGIAYLASEDGQRIQKRAHDEIMKVYPDGDAWEKCLLEEKVPY
VTALVKETLRFWTVIPICLPRENTKDIVWNGAVIPKGTTFFMNAYAADYD
ETHFTNPHAFEPERYLTASSDGSGTPHYGYGAGSRMCAGSHLANRELFTA
YVRLITAFTMHPAKRAEDRPILDAIECNAIPTALTTEPKPFKVGFKPRDP
VLVRKWIAESEERTKHLN*
>CYP504A2v1 Penicillium chrysogenum strain
Wisconsin 54-1255
GenEMBL AF056978.1
phenylacetate hydroxylase (pahA) gene
MAIQTLAVAVITVVYFVIRYFNRTDIPKIKGLPEIPGIPIFGNL
LQLGDQHATVTGKWAKKFGPVFQVRMGNKRIVFANGFDSVRQLWIKDSSALISRPTFH
TFHSVVSSSQGFTIGTSPWDDSCKKRRKAAATALNRPAVQSYMPIIDLESNSSIKELY
RDSQNGKRDVNPTAYFQRYAFNTSLTLNYGFRIEGNVDDTLLHEIVDVERGVSNFRST
SNNWQDYIPLLRIFPKMNNEAADFRGRRDKYLTYLLDMLKDRIAKGTDKPCITGNILK
DPEAKLNDAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQKKAYDAIMEVYP
DGDAWEKCLVEEKVPYVTALVKEVLRFWTVIPICLPRESTKDIQWNGATIPAGTTFFM
NVWAADYDEDHFKDADKFIPERYLEASEGAGTPHYAYGAGSRMCAGSHLANRELFTAF
IRLVTAFNMHTAKETADRPILNAIECNLIPTALTTEPKPFKVGFSARDPKKLEQWIAE
SDERTKDL
>CYP504A3v2 Aspergillus terreus
AAD34565.1
6 aa
diffs to 504A3v1
ATEG_09973.1
6 aa diffs
1 MTLQIIVIAA TAVIYFLTRY FNRTDIPKIK GIPEIPGVPI FGNLIQLGVK HATVARKWSK
61 EFGPVFQARL GNRRVIFANT FESTRQLWIK EQSSMISRPT FHTFHGVVSS
SQGFTIGTSP
121 WDESCKRRRK AAATALNRVA VQSYMPIIDL
ESMASIKELL KDSQGGKIDI NPTPYFQRFA
181 LNTSLTLNYG YRIEGNVNDQ LLREICEVQR
GVANLRSTSN NWQDYVPLLR LFSNRSNQAK
241 HLRARRDKYM AFLFDILKDR MAKGTDKPCI
TGNILKNPET KLTDAEIKSI CLTMVSAGLD
301 TVPGNLIMGI AYLSSEDGQR IQQKAYEEIM
SVYPNGDAWE RCLVEEKVPY ITALVKETLR
361 FWTVMPICIP RVNIKEVIYN GARIPAGTTF
FMNAWAANYD EDHFDMPNRF LPERYLEPSE
421 GFGTPHYSFG AGTRMCAASH LASRELYTVF
LRFIVAFTIE PAQNPADMPV LDAIECNATP
481 TSMTTEPKPF KVGFKPRDET SLRRWIAESE ERTKEL
>CYP504A4 Magnaporthe grisea MG04684.4 71% to CYP504A1 AACU01001145 cont2.876
MQSFVVIAGLLAAAYFVHRLLYGTDTPHIKGLPEVPGLPLFGSLIELGDN
HAKVAQRWAEKYGPVFQVRMGNRRIVFANTFASVRHLWITNQSALISRPK
LHTFHTVVSSSQGFTIGTSPWDDSCRRRRKAAATALNRPAVQSYMPLIDL
ESTVSIRELLQDSRGGAVDLDPRAYWQRYALNTSLTLNYGYRIDGDKDDE
LLREITDVERGVSNFRSTSNNWQDYVPLLRLFPKMSREAVEFRERRDVYM
DRLLRGLKERIERGMDKPCISGNILKDPEAKLNEAEIKSIGLTMVSAGLD
TVPGNLIMGIAYLASPAGQEIQQRAYAEILKTYPANDAWTRCLDEEKIPY
ITALYKEILRFFTVIPICLPRVSVKDVEWEGVTMPAGTTFYMNAYAADYD
AAHFSDPYVFNPDRYLEDVEGTPHYGYGAGSRMCAGSHLANRELYTAFVR
LISAFEFVPPADPADEAVLDCLEANAIPTSLTMEPKYFKVGFRPRDRDVL
DGWIRESEERTRHLM*
>CYP504A5 Fusarium graminearum
AACM01000162.1 revised GC boundary at KLNE old name = 504A3
MSDQILYVTVLVGLLLLYRLANSTDKPKIKGIPEIPGVPLFGNLFQLGTD
HARVARKWVAKYGPVFQTRLGNKRVVYVNSYDAVKHFWITHQSALISRPM
FHTFHSVVSTSQGFTIGTSPWDESCKARRKAAATALNRPATQSYMPILDL
ESFVSIKELFDDCEKGTKDLDPSPYFARFALNTSLTLNYGYRINGDVNSE
LLHEITHVEREISNFRSTSNNWQDYVPLLRLWGAQNS
SAGEFRARRDKYLTDMLNHLKSRIAEGTDKPCITGNILKDPEAKLNE
(1)
AEIKSICLTMVSAGLDTVPGNLIM
GIAYLATPHGQEIQAKALEEIYKVYPNGEAWERCLVEEKVPYITALVKEI
LRFWTVIPICLPRVNIKDIPYKGATIPAGTTFFMNAYAADYDESRFAKPF
EFNPERYMDDKEIGTPHYAYGAGSRMCAGSHLANRELYTAFIRLITAFEM
VPPKDKSDEAIMDSIECNAVPTSLTTDPKPFKVGFKTRSESRLREWIAAA
DERTKELR*
>CYP504A6 Nectria haematococca
e_gw1.24.52.1 same gene as fgenesh1_pg.scaffold_24000130
Necha1/scaffold_24:331011-332725
72% to CYP504A1 Emericella nidulans phacA gene
85% to 504A5 Fusarium graminearum FG03741.1 AACM01000162
MSSLVLYLAAVVVLYALIRFLNSTDIPKIKGIPEIPGVPIFGNLIQLGTDHARVAQKWAAKYGPVFQTRLGTK
(0)
RVVFVNSYDSVKHFWITHQAALISRPTFHTFHSVVSSSQGFTIGTSPWDDSCKARRKAAATALNRPAVQS
YMPILDLESTTSIRELLEDCDNGNSDLDPSPYFARFALNTSLTLNYGFRIDGDVNSELLHEITHVEREIS
NFRSTSNNWQDYVPLLRLWGAQNSAAGEFRARRDKYLTDMLNDLKQRIANGTDKPCITGNILKDPEAKLNE
(1)
AELKSICLTMVSAGLDTVPGNLIMGVAYLATPEGQKIQAKALQAIQEVYPNGEAWEKCLVEEKVPF
ITALVKETLRYWTVIPICLPRVNIRDIPYKDTVIPAGTTFFM (0)
NAYAADYDEARFRSPYEFIPERFLDDKEVGTPHYGYGAGSRMCAGSHLANRELYTAYIRIITAFEILPPKD
KTDFPVMDAIECNANPTSLTTDPKPFKVGFKIRSESKLREWIAEAEERTRGL*
>CYP504A7 Aspergillus fumigatus Af293
GenEMBL XP_748171.1 also
phenylacetate 2-hydroxylase (predicted)
85% to 504A1
MAQTIVLAVLAAVYLLIRYLNRTDIPKIKGLPEIPGVPIFGNLLQLGDRHATVAARWAKKYGPVFQVRMG
NKRIVFANSFESVKQLWIKDQSALISRPTFHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAV
QSYMPIIDLESTASIKELLKDCRNGAVDINPTAYFQRFALNTSLTLNYGFRIEGNVDDALLREIVDVERG
VSNFRSTSNNWQDYIPLLRIFPKTNREAEEFRVRRDKYLTFLLDMLKERIAKGTDKPCITGNILKDPEAK
LNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEAGQRIQQKAYEEILKVYPNGDAWEKCLVEEKVPYI
TALVKETLRFWTVIPICLPRESTKDIVYNGATIPAGTTFFMNAYAADYDDEHFKMPDKFIPERYLDVSEG
SGTPHYGYGAGSRMCAGSHLANRELYTAYIRLITAFTMHPARDPADQPILDAIECNAIPTALTTEPKPFK
VGFKPRDASKLQQWIAESDERTKEL
>CYP504A7 Neosartorya fischeri
XM_001266358.1, XP_001266359.1
77% to
504A3, 97% to CYP504A7 Aspergillus fumigatus
NFIA_040380
Name
revised from CYP504A10
MAQTIVIAVLAAVYFLIRYLNRTDIPKIKGLPEIPGVPVFGNLL
QLGDRHATVAAKWAKKYGPVFQVRMGNKRIVFANSFESVKQLWIKDQSALISRPTFHT
FHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLEATASIKELLK
DCRNGAVDINPTAYFQRFALNTSLTLNYGFRIEGNVDDALLREIVDVERGVSNFRSTS
NNWQDYIPLLRIFPKTNREAEEFRVRRDKYLTFLLDMLKERIAKGTDKPCITGNILKD
PEAKLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQQKAYEEIMKVYPN
GDAWEKCLVEEKVPYVTALVKETLRYWTVIPICLPRESTKDIVYNGATIPAGTTFFMN
AYAADYDDDHFKMPDKFIPERYLDVSEGSGTPHYGYGAGSRMCAGSHLANRELYTAYI
RLITAFTMHPARDPADQPILDAIECNAIPTALTTEPKPFKVGFKPRDTSKLQQWIAES
DERTKEL
>CYP504A8 Aspergillus oryzae
GenEMBL BAE58419.1
86% to
504A1, 45% TO 504B6
MSLQTIAIAAIAVAYFIIRYLNRTDVPKIKGIPEIPGVPLFGNLLQLGDQHATVAGKWAKKFGPVFQVRM
GNKRVVFANSFDSVRQLWIKDQAALISRPTFHSFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPA
VQSYMPIIDLEATASIKELLKDSQNGTVDVNPTAYFQRFALNTSLTLNYGFRIEGNVDDELLKEIVDVER
GVSNFRSTSNNWQDYIPLLRIIPKMNREAEEFRVRRDKYLTYLLDILKDRIAKGTDTPCITGNILKDPEA
KLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQQKAYDEIMKVYPDGDAWEKCLVEEKVPY
VSALVKETLRFWTVIPICLPRVNIKEIEFNGAKIPAGTTFFMNAWAADYDEDHFKMPEKFLPERYLEVSE
GSGTPHYGYGAGSRMCAGSHLANRELYTAYIRLITAFTMHPAQNPADRPILDAIECNEIPTALTTEPKPF
KVGFKPRDAPKLQQWIMESDERTKDL
>CYP504A8 Aspergillus flavus
99% to CYP504A8 Aspergillus oryzae
AFL2G_01710
MSLQTIAIAAIAVAYFIIRYLNRTDVPKIKGIPEIPGVPLFGNLLQLGDQHATVAGKWAKKFGPVFQVRMGNKRVVFANS
FDSVRQLWIKDQSALISRPTFHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLEATASIKELL
KDSQNGTVDVNPTAYFQRFALNTSLTLNYGFRIEGNVDDELLKEIVDVERGVSNFRSTSNNWQDYIPLLRIIPKMNREAE
EFRVRRDKYLTYLLDILKDRIAKGTDTPCITGNILKDPEAKLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQR
IQQKAYDEIMKVYPDGDAWEKCLVEEKVPYVSALVKETLRFWTVIPICLPRVNIKEIEFNGAKIPAGTTFFMNAWAADYD
EDHFKMPEKFLPERYLEVSEGSGTPHYGYGAGSRMCAGSHLANRELYTAYIRLITAFTMHPAQNPADRPILDAIECNAIP
TALTTEPKPFKVGFKPRDAPKLQQWIMESDERTKDL
>CYP504A9 Aspergillus terreus
XM_001218406.1 XP_001218407.1
79% to 504A3
ATEG_09785.1
MALQTLAIAAAAVVYFIIRYFNRTDVPKIKGLPEIPGVPIFGNL
LQLGDKHATVAGAWAKKYGPVFQVRMGNKRVVFANSFDSVRQLWIKDQSALISRPTFH
TFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLECTASIRELL
KNSQGGTVDLNPAPYFQRFALNTSLTLNYGFRIEGNVDDQLLREIVDVERGVSNFRST
SNNWQDYIPLLRIFPKMNTEAEEYRVRRDKYLTYLLDILKDRIAKGTDKPCITGNILK
DPEAKLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQEKAYDEIMKVYP
NGDAWEKCLVEEKVPYITALVKETLRFWTVIPICLPRESTKEIVYNGAKIPAGTTFFM
NAWAADYDEDHFKMADRFIPERYLEQSEGAGTPHYGYGAGSRMCAGSHLANRELYTAF
IRLITAFTMHPAQNKEDLPVLDAIECNAIPTALTTEPKPFKVGFKPRDAALLEKWIAE
SDERTKEL
>CYP504A11 Aspergillus clavatus NRRL 1
XP_001276373.1, ACLA_003600
74% to
504A3
1 MTLQTLAFAV VAAVYLVIRY LNRTDVPKIK GIPEIPGVPL FGNLLQLGDQ HATVAAKWAK
61 QYGPVFQVRM GNRRIVFANS FDSVRQLWIK DQSALISRPT FHTFHSVVSS
SQGFTIGTSP
121 WDESCKRRRK AAATALNRPA VQSYMPIVDL
EATASIKELL KNGQNGAVEL NPTAYFQRFA
181 LNTSLTLNYG FRIEGNVDDQ LLREIVDVER
GVSNFRSTSN NWQDYIPLLR ILPKTNREAE
241 EFRERRDKYL TYLLDILKDR IAKGIDKPCI
TGNILKDPEA KLNEAEVKSI CLTMVSAGLD
301 TVPGNLIMGI AYLASEDGQR IQQKAYDEIM
KVYPNGEAWE KCLVEEKVPY VTALVKETLR
361 FWTVIPICLP RESTKDIVYN GATIPAGTTF
FMNAYAADYD ADHFKFPEKF IPERYLDVGE
421 GSGTPHYGYG AGSRMCAGSH LANRELFTAY IRLITAFTMH
PARDPTDRPI LDAIECNDIP
481 TALTTEPKPF KVSFKPRDAK TLQRWIEESD ERTREL
>CYP504A12 Coccidioides immitis RS
XP_001243121.1 also CIMG_07017.2
71% to
504A3
1 MGYQTIAIAV VAVVYFVIKQ LNKTDIPKIK NLPEIPGVPM FGNLIQLGDS HAKKAQDWVK
61 KYGEVFQVRL GNKRIIFANT FDSVKHFWIT HQSSLISRPT LHTFHTVVSS
SQGFTIGTSP
121 WDESCKRRRK AAATALNRPA VQSYMPIIDL
ESTVSIKELL NDSKDGTVDV DPNPYFQRFA
181 LNTSLTLNYG IRIDGSIEDE LLKEICHVER
VVSNFRSTSN NWQDYIPLLR LWPSRNNEAK
241 EFRERRDRYL SLLLDMLRDR IAKGTDKPCI
TGNILKDPEA KLNEAELKSI CLTMVSAGLD
301 TVPGNLIMGI AYLASAHGQE IQERAYQEIM
KVYPDGDAWE RCLVEEKVPY ITAFVKEVLR
361 FWTVIPICLP RVSIKDIEYK GATIPAGTTF
FMNAYAADYD ENHFKNPYEF RPERYLNVSD
421 GAGTPHYAYG AGSRMCAGSH LANRELYTAF
LRLISAFRIV PAKNRADDPI LDCLEAGINK
481 CALTLDPKQF KVGFKVRDRA KLDAWIQGSD ERTKDL
>CYP504A13 Phaeosphaeria nodorum SN15
EAT85524.1
64% to
504A3
1 MTIPLYVAGV AVLGFYLYRL LYGTDKPHIK GLPEVPGLPL FGSLVELGTN HAKVAQGWAK
61 KYGPVFQVRM GNRRIVFANS FDSVRHLWIT HQSALISRPT LHTFHTVVSS
SQGFTIGTSP
121 WDESLKNRRK AAGTALNRPA VQSYMPLIDL
ESTVSIRELL NDSKGGELDI DPRAYWQRYA
181 LNTSLTLNYG FRIDGDKDAP LLKEICDVER
GVGNFRSTSN NWQDYVPLLR LFPSQSNEAK
241 KFRDRRDVYM NKLLDTLLEK IEKGTDKPCI
TGNIIKDPDA KLNRAELKSI CLTMVSAGLD
301 TVPGNLIMGI AQLATPSGQS IQRRAHAEIL
KVYPNNDAWH KCLEEEKIPY ITALYKEILR
361 YWTVIPISLP RQSIKDIEYN GVTFPAGTTF
YMNAYAADYD DTHFSDPYTF NPERYLDVPD
421 GTGTPHYGYG AGSRMCIGSH LANRELYTAF
VRLISAFEFT EPVDERDKPI MDCLEANAIP
481 TSLTLEPKYF KVGFKPRDRA LLEKWLGESE
ERTRELKGMG K
>CYP504A14 partial Gibberella moniliformis cDNA DR661198
87% to 504A3
MSDQVIYLAIIIGLYMLYK
LANSTDQPKIKGIPEIPGVPLFGNLIQLGTDHARVA
QKWAKKYGPVFQTRLGTKRVIYVNSYEAVKHFWITHQSALISRPMFHTFHSVVSSSQGFT
IGTSPWDESCKNRRKAAATALNRPAVQSYMPILDLESLVSIEELLNDCKDGSKDLDPSPY
FARFALNTSLTLNYGFRIDGDVNSELLHEITYVEREISNFRSTSNNWQDYVPLLRLWGAQ
NSSAEEFRVRRDKYLSDLLANLKSRIDNGTDKPCITGNILKDPTAKLNDAEIQSICLTMV
SAGLDTV
>CYP504A15 Aspergillus niger
fgenesh1_pm.C_scaffold_7000252|Aspni1
88% to CYP504A8
MAVQTILIAAAAVIYFLVRYMNRTDVPKIKGIPEIPGVPLFGNLLQLGTQHAVVARKWAKSFGPVFQVRMGNKRVVFANS
FDSVRQLWIKDQSALISRPTFHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLECTASIKELF
KDSQNGARDINPKAYFQRFALNTSLTLNYGFRIEGNVNDELLHEIVNVERGVANFRSTSNNWQDYIPLLRIFPKQNREAQ
EFRERRDKYLSYLLEILKDRIAKGTDKPCITGNILKDPEAKLNEAEIKSICVTMVSAGLDTVPGNLVMGIAYLASEDGQR
IQQKAYDEIMKVYPNGDAWEKCLVEEKVPYVSALVRETLRFWTVIPICLPRESTKDIEYNGATIPAGTTFFMNAWAADYD
EDHFKMPEKFIPERYLDVGEGSGTPHYGYGAGSRMCAGSHLANRELFTAYVRLITAFTMHPSRDLADRPILDALECNEIP
TGLTTEPKPFKVGFTPRDPTKLQQWIAESDERTKDL*
>CYP504A16 Mgr075 Mycosphaerella graminicola
67% to CYP504A12 Coccidioides immitis
MAQSPEPQSLTGLLFTPQVFPFFILAVIYAAIKIIDRTDIPKIKGLPEVPGVPIFGNLRQLGDNHAVNAMKLAKKYGPVFQVRLGNRRIVFANTFDSVRNLWITNQSALISRPKLHTFHTVVSSSEGFTIGTSPWDESCKKRRKAAATALNRPAVQSYMPIIDYESIKSIKEMLQDSQQGQIDIDPNPYFQRYALSTSLTLNYGIKIEGNIDDGMLQEIVHVEREVSNFRSTATNWADYIPMLRLLPGGSDKPLEYKKRRAAYMHKLLGMLKSRIADGTDAPCISGNVLKDPEAKLTDAEVMSIGLTMVSAGLDTVPGNLIMCIAYLSSPHGQEIQSRALAEIQKVYPNNDSWKRCLHEEKCSYITALVKETLRFWSVIPVCLPRTSTKPIQWEGVTIPAGTSFYMNAYAAHYDDSHFSSPFDFNPDRYLADDSIDDAAASRGTPHYGYGAGSRMCIGSHLANRELYTAFLRMITAFEILPPKRESDRPILDAMGCNKLPNGLTMDPKGFKIGLRVRDKGALERWMREGEERTRSL
>CYP504A17 Yarrowia lipolytica
49% to CYP504A6 Nectria haematococca
CAG77765.1
MLLQLLSSILLAVLTFIILDWLFEIDTETPHIAGLPAKRGYPIVGAVFQLGKSHPLTYRKWSEELGPVYQVRLGNKRVVV
ANSYASVRELWITNMRANISRPESYTFHKLLSSKDGPTIGTTPWGVSARRKRRAASTALNKPSVAAYTPIINLESYKCIR
RFLRDCGGIEGEVDVSVGLATYSLNTSLTLNYGIMTADFDSTYLAEVMDIEERILRLRSTMHNTQDYIRYLRVFSRGSTV
EAAECRERRAQYMTKFLKKLKQEIDDGTDMPCIAGNILKDKESKITDADLRSICLTMVSAGFDTVPANLISCFGHLSHSY
GQTIQKRALEAIDRAYPDGDAWEMCLMDDSKVHYIVALCEETVRYGSVVPMALPRRTINDIHYQGAVIPAGTILFMNAFA
ANFDATRFHDPFKFDPERYLDLDGRLKTELGPAHFGFGAGSRMCCGIHLARKELYVALVRFILAFRILPPVDPKDMMVND
PVEIFAQPENMTTKPPPFKVRLQVRDAEKLDRWLKETKEGLGETWSVGHD
>CYP504A18 Uncinocarpus reesii
94% to CYP504A12 Coccidioides immitis
UREG_05848.1
MGYQTIAIAAVAFVYFVIKQLNKTDIPKIKNLPEIPGVPIFGNLIQLGDSHAKRAQEWVKQYGEVFQVRLGNKRIIFANT
FDSVKHFWITHQSALISRPTLHTFHTVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLESTASIKELL
HDSKDGTVDIDPNPYFQRFALNTSLTLNYGIRIDGSIEDELLKEICHVERVVSNFRSTSNNWQDYIPLLRLWPSRNNEAK
EFRERRDKYLSLLLDMLRDRMAKGTDKPCITGNILKDPEAKLNEAELKSICLTMVSAGLDTVPGNLIMGIAYLSTAHGQE
IQDRAYKEIMQVYPNGDAWERCLVEEKVPYITALVKEVLRFWTVIPICLPRVSVKDIEWKGATIPAGSTFFMNAYAADYD
ENHFKNPYEFRPERYLNVSDGAGTPHYAYGAGSRMCAGSHLANRELYTAFLRLISAFRIVPAKNRADDPIMDCLEAGINK
CALTLDPKQFKVGFRVRDRAKLDSCIQGSDERTKDL
>CYP504A19 Histoplasma capsulatum G217B
80% to CYP504A12 Coccidioides immitis
ABBT01000061.1 Ajellomyces capsulatus G217B
HCB01876.1
154004
MGLQTAVVAVIAVGFLLIRYLNRTDIPKISKLTEIPGIPIFGSLIQLGEEHARVAAGWVK 154183
154184
KYGPVFQVRLGNK (0) 154222
154380
RIVFANTFDSVKYFWITHQSALISRPTLHTFHTVVSSSQGFTIGTSPWDESCKRRRKAAA 154559
154560
TALNRPAVQSYMPIIDLESNVSIRELFHDSKGGTVDIDPNAYFQRFALNTSLTLNYGIRI 154739
154740
DGNIDNELLKEICHVERIVSNFRSTSNNWQDYVPLLRLWPSRNSEAKEFRIRRDKYLTLL 154919
154920
LDMLRERIKNGTDKPCITGNILKDPDAKLNE (1)
AEIKSICLT
MVSAGLDTVPGNIIMGIAYLASDHGQQIQARAYDEIMKVYPNGDAWEKCLVEEKVPYITALVKEVLRFFTVIPICLPRVS
IKDIPYEGAVIPAGTTFFMNAYAADYDATHFKNPHLFEPERYLSATDGSGTPHYAYGAGSRMCAGSHLANRELYTAFIRL
ITAFRMMPARDPRDHPILDALDCNATKTSLTLDPMPFKVWFRVRDAESLERWMRESEERTREL*
155999
>CYP504A20 Fusarium oxysporum
85% to CYP504A5 Fusarium graminearum
FOXG_09779
MSDQVIYLAIIIGLYVLYKLANSTDQPKIKGIPEIPGVPLFGNLIQLGTDHARVAQKWAKKYGPVFQTRLGTKRVIYVNS
YEAVKHFWITHQSALISRPMFHTFHSVVSSSQGFTIGTSPWDESCKNRRKAAATALNRPAVQSYMPILDLESL
VSIKELL
DDCKDGS KDLDPSPYFARFALNTSLTL NYGFRIDGDVNSE
LLHEITYVEREISNFRSTSNNWQDYVPLLRLWGAQNSSAE
EFRVRRDKYLSDLLANLKSRIDNGTDKPCITGNILKDPTAKLNDAEIKSICLTMVSAGLDTVPGNVIMGIAYLATEHGQK
IQAKALKEIYKVYPNGEAWERCLVEEKVPYVTALVKEILRFWTVIPICLPRESIKDIPYQGAVIPAGTKFFMNAYAADYD
ETRFANPYEFDPERYIDDKEVGTPHYAYGAGSRMCAGSHLANRELYTAFIRLITAFEILPPKDNKDFPVMDCIECNANPT
SLTTDPEPFKVGFKPRDEAKAREWIAAGEERTQDIR*
>CYP504A20P Fusarium verticillioides
96% to CYP504A20 Fusarium oxysporum = ortholog with 3
frameshifts
FVEG_08703
MSDQVIYLAIIIGLYMLYKLANSTDQPKIKGIPEIPGVPLFGNLIQLGTD
HARVAQKWAKKYGPVFQTRLGTKRVIYVNSYEAVKHFWITHQSARISRST
FHTFQSVVSSSQVFTIGTSPLDESCKNRRKAAATALNRPAVQSYMPILDLESL
VSIEELLNDCKDGS &
KDLDSS &
PYFVRIALNTSLTL &
NYGFRIDGDVNSE
LLHEITYVEREISNFRSTSNNWQDYVPLLRLWGAQNSSAEEFRVRRD
KYLSDLLANLKSRIDNGTDKPCITGNILKDPTAKLNDAEIKSICLTMVS
AGLDTVPGNVIMGIAYLATEHGQKIQAKALKEIYKVYPNGEAWERCLVEEK
VPYVTALVKEILRFWTVIPICLPRESIKDIPYQGTVIPAGTKFFMNAYAA
DYDESRFANPYEFNPERYIDDKEVGTPHYAYGAGSRMCAGSHLANRELYT
AFIRLITAFEILPPKDKKDFPVMDCIECNANPTSLTTDPKPFKVGFKPRD
EAKAREWIAAGEERTQDIR*
>504B1 Aspergillus
nidulans AACD01000019.1 ANcontig1.19 68186 to 69958
MAIAEALLFV NNRAVEHPLQ
FLTAVAFAVP LLYVVINEFI RASARIPGFK GPRGLPLIGN
LAQIRKDAAE
QYRIWSKIYG PVYQIQLGNI PVLVVNSAAA AKVLFGQNAQ ALSPRPEFYT
FHKIVSNTAG
TTIGTSPYSE SLKRRRKGAA SALNRPSVES YVHHLDVESK AFVAELFKYG
NGGKTPVDPM
AMIQRLSLSL ALTLNWGVRV ASQEEELFDE ITEVEDKISK FRSTTGNLQD
YIPILRLNPF
SSNSHKAKEM RDRRDKYLSS LNRDLDDRME KGTHKPCIQA NVILDKEAKL
NSEELTSISL
TMLSGGLDTV TTLVAWSISL LAQRPDIQDK AAKAIQEMYS EGQPLCDPAD
DQKCAYVAAL
VRECLRYYTV LRLALPRTSI RDITYDGKVI PKGTVFFLNA WACNMDPEVW
SDPDEFRPER
WFEQPDAPMF TYGMGYRMCA GSLLANRELY LVFIRTLNSF RIEPTEEKIE
WHPLKGNSDP
TSLVAIPKKY KVRF
VPKNEV SLVEALS
>CYP504B1 Aspergillus nidulans AN1397.1 63%
to 504B2 100% to 504B1
MAIAEALLFVNNRAVEHPLQFLTAVAFAVPLLYVVINEFIRASARIPGFK
GPRGLPLIGNLAQIRKDAAEQYRIWSKIYGPVYQIQLGNIPVLVVNSAAA
AKVLFGQNAQALSSRPEFYTFHKIVSNTAGTTIGTSPYSESLKRRRKGAA
SALNRPSVESYVHHLDVESKAFVAELFKYGNGGKTPVDPMAMIQRLSLSL
ALTLNWGVRVASQEEELFDEITEVEDKISKFRSTTGNLQDYIPILRLNPF
SSNSHKAKEMRDRRDKYLSSLNRDLDDRMEKGTHKPCIQANVILDKEAKL
NSEELTSISLTMLSGGLDTVTTLVAWSISLLAQRPDIQDKAAKAIQEMYS
EGQPLCDPADDQKCAYVAALVRECLRYYTVLRLALPRTSIRDITYDGKVI
PKGTVFFLNAWACNMDPEVWSDPDEFRPERWFEQPDAPMFTYGMGYRMCA
GSLLANRELYLVFIRTLNSFRIEPTEEKIEWHPLKGNSDPTSLVAIPKKY
KVRF
DLISELIREYDTR*
>CYP504B2 Magnaporthe grisea MG03352.4 63% to 504B1 Aspergillus nidulans
AACU01000699 cont2.663
MAITSLVAWAAGPATSFSCVRICTLAVTSIVLYFVINEIIRAKSRIKGLA
GPRGLPLIGVLWDIRTNAAEQYRRWAKRYGDVYQVQLGNVTVVVVNSAES
ARTLFGHNSQALSSRPEFYTFHKVLSDTAGTTIGTSPYSESLKRRRKAAA
SALNRPSVASYVGILDLETRDFVLEMVAYGKHGTKAIDPMPMIQRLSLSL
ALTLNWGSRVASQHDGLFSEITHVEEEISKFRSTTGNLQDYVPLLRINPF
NGHSARAREMRNRRDVYLKHLDDDLRRRMAAGTQRPCIQANIILDDNDIK
ADSAQRLSKAEMTSISLTMLSGGLDTITTNVAWFIALLVQRPDIQEKAHL
EIRKHLIDQVQPDRSDPLGLCDAEDDQGCRYVAALVRESLRYYTVLRLAL
PRVSVREVVHEGVVLPRGTVFFLNAWACNMDAKVWTDPEVFRPERWLEQP
DAPLFTYGVGYRMCAGSMLANRELYLLYMRLIAHFKIDPVPAKDGCDGID
VVDCHPVSGNCDPTSLVAIPRPYKVLFVPRDLDFIGMSVA*
>CYP504B3 Fusarium graminearum FG06447.1
AACM01000259 FGcontig1.259_scaffold4
MTIANILLSLNDKVQKNKGQSILITLFIAPLVYILVNELVRHNARISNLD
GPWGLPLIGNIRDIKVNASEKYREWAKKYGPVYQIQLGNIPIVVVNSAAA
ARHIFGANAQALSSRPEFYTFHKVNHTTPNTCQGXXXXXXXXXXXXXXAASALNRPSVATYVDH
LDVETRDFIKELIEYGNNGKSPVDPMPMIQRLSLSLALTLNWGVRLKSQK
DNLFAEITHVEEEISRFRSTTGNLQDYIPLLRLNPFNFHSSKAREMRNRR
DKYLTALNDGLDERIKNGTSKPCIQANVIMDKEXXXXXXXAKLNKDELTSISLTMLS
GGLDTVTTLVAWFVAYLSQHPEIQDKAVSEIGKFFSQKEPXXXXXXXMCDANDDQKC
EYVVALVKESLRYYTVLRLALPRASIRDIIYEGVKIPKGTVVFLNAWACN
MDEQVWSDPQEFRPERWLEQPEAPLFTYGVGYRMCAGSLLANRELYLLYM
RLLNSVKIEQXXXXXXXXXFDNVDCHPVRGNLDPTSLVAMPRRYKASFTPRSPDDLKKA
LVVSV*
>CYP504B4 Nectria haematococca
e_gw1.24.45.1
Necha1/scaffold_24:269356-271018
79% to 504B3 F. gram.
43% to e_gw1.24.52.1, 66% to 504B1 Aspergillus nidulans
This gene model seems correct
MTIANLLVSLNDKVQENKGQSVLLTLVIAPLIYLFINELVRHNARISNLQGPSGLPLIGNIWDIHINAAE
KYREWSRKYGKVYQIQLGNIPIVVVNSASAARTIFGANAQALSSRPEFYTFHK
(0)
VLSDTAGTTIGTSPYSD
SLKRRRKGAASALNRPSVATYVDHLDIETRDFIKELCNYGEAGKIPVDPMPMIQRLSLSLALTLNWGIRL
KSQEDDLFNEITHVEEEISRFRSTTGNLQDYIPLLRLNPLNLSSSKARSMRDRRDKYLGDLNRGLDERIA
NGTYKPCIQANVIMDKEAKLNKDELTSISLTMLSGGLDTITTQVAWSIAYFAQHPEIQEKAKAEIEKFYA
TNQPMCDEEDDQKCQYIVALVRESLRYFTVLRLALPRASIRDVVYNGVTIPKGTVVFLNAWACNM
(1)
DEQVWTDPEVFRPERWLEQPDAPLFTYGVGYRMCAGSLLANRELYLLYMRLLNSFKIEKHDDIDCDPITGNLDPT
SLVAMPRRYKAVFTPRDPKALKAALAQQVE*
>CYP504B5 Aspergillus fumigatus Af293
GenEMBL XP_752247.1 also EAL90209.1
phenylacetate hydroxylase predicted
68% to
504B4
MAIAAAVSSLQQNVLRHPLQSLAITALVVPIIYIIINEFIRASARVPGFKGPRGLPLIGNLAQIRKNAAE
QYRIWSKTYGPVYQIQLGNIPIIVVNSAAAAKILFGQNAQALSSRPEFYTFHRIVSNTAGTTIGTSPYSE
SLKRRRKGAASALNRPSVESYVSHLDVETKAFVAELLKYGNGGKTPVDPMAMIQRLSLSLSLTLNWGVRV
ASQEEDLFNEITHVEEEISKFRSTTGNLQDYIPLLRLNPFSTNSRKAKEMRDRRDRYLNALNRDLDDRME
KGIHKPCIQANVILDKEAKLNKEELISISLTMLSGGLDTITTLVAWSFCLLSRRPDIQEKAAQAIQDMFS
QDEPLCDAQDDQKCAYVAALVRECLRYYTVLRLALPRTSIKDITYDGKVIPKGTVFFLNSWACNMDPEVW
NDPEEFRPERWFEQPDAPMLTYGIGYRMCAGSLLANRELYLVFMRTLNSFHIEPHDDVDWHPINGNSDPT
SLVAIPKKYKVRFVPKNEQALTRALA
>CYP504B5 Neosartorya fischeri
98% to CYP504B5 Aspergillus fumigatus =
ortholog
NFIA_016920
MAIAAAVSSLQQNVLRHPLQSLAVTALVVPIIYIVINEFIRASARVPGFKGPRGLPLIGNLAQIRKNAAEQYRIWSKTYG
PVYQIQLGNIPVIVVNSAAAAKILFGQNAQAVSSRPEFYTFHRIVSNTAGTTIGTSPYSESLKRRRKGAASALNRPSVES
YVSHLDVETKAFVAELLKYGNGGKTPVDPMAMIQRLSLSLSLTLNWGVRVASQEEDLFDEITHVEEEISKFRSTTGNLQD
YIPLLRLNPFSTNSRKAKEMRDRRDRYLNALNRDLDDRMEKGIHKPCIQANVILDKEAKLNKEELISISLTMLSGGLDTI
TTLVAWSFCLLSRRPDIQKKAAQAIQDMFSQDEPLCDAQDDQKCAYVAALVRECLRYYTVLRLALPRTSIKDITYDGKVI
PKGTVFFLNSWACNMDPEVWSDPEEFRPERWFEQPDAPMLTYGIGYRMCAGSLLANRELYLVFMRTLNSFYIEPHDDVDW
HPINGNSDPTSLVAIPKKYKVRFVPKNEQALTQALA*
>CYP504B6 Aspergillus oryzae
GenEMBL
BAE56546.1
82% to 504B1
MAITATLFSIQKSLIHTPLQSIAIAALFTSCLYFIVNEFIRAFSRVPGFKGPRGLPLIGNIAQIRKNAAE
QYRIWSKTYGPVYQIQLGNIPVIVVNSAVSAKAIFGQNAQALSSRPEFYTFHK
IVSNTAGTTIGTSPYSD
SLKRRRKGAASALNRPSVESYVSHLDAESKAFVAELLKYGEGGNVPVDPMAMIQRLSLSLALTLNWGVRV
VSQEEDLFNEITHVEEEISKFRSTTGNLQDYIPLLRLNPFNTNSKKAKEMRDRRDKYLNGLNRDLDDRME
KGIHKPCIQANVILDQEAKLNSEELTSISLTMLSGGLDTVTTLVAWSIGLLAKRPDIQDKAAEAILNMYG
PNQPMCDAADDQRCAYVAALVRECLRYFTVLRLALPRTSIRDITYGGNIIPKGTVFFLNSWACNMDPDTW
SDPEEFRPERWLEQPDAPLFTYGLGYRMCAGSLLANRELYLIFMRTINSFRIEPYDEIDWHPVHGNADPT
SLVAIPKKYKV
RFIPRDNKVLEDVLGSAFSLKRVI
>CYP504B6 Aspergillus flavus
100% to CYP504B6 Aspergillus oryzae
AFL2G_01532
MAITATLFSIQKSLIHTPLQSIAIAALFTSCLYFIVNEFIRAFSRVPGFKGPRGLPLIGNIAQIRKNAAEQYRIWSKTYG
PVYQIQLGNIPVIVVNSAVSAKAIFGQNAQALSSRPEFYTFHK
(0)
IVSNTAGTTIGTSPYSDS
LKRRRKGAASALNRPSVESYVSHLDAESKAFVAELLKYGEGGNVPVDPMAMIQRLSLSLALTLNWGVRVVSQEEDLFNEI
THVEEEISKFRSTTGNLQDYIPLLRLNPFNTNSKKAKEMRDRRDKYLNGLNRDLDDRMEKGIHKPCIQANVILDQEAKLN
SEELTSISLTMLSGGLDTVTTLVAWSIGLLAKRPDIQDKAAEAILNMYGPNQPMCDAADDQRCAYVAALVRECLRYFTVL
RLALPRTSIRDITYGGNIIPKGTVFFLNSWACNMDPDTWSDPEEFRPERWLEQPDAPLFTYGLGYRMCAGSLLANRELYL
IFMRTINSFRIEPYDEIDWHPVHGNADPTSLVAIPKKYKV
RFIPRDNKVLEDVLGSAFSLKRVI*
>CYP504B7 Aspergillus niger
estExt_fgenesh1_pm.C_30542|Aspni1
85% to CYP504B5
MAIAAVLSFLQQSILESPLQSLAATAFIVPVLYIIINEFIRASARVSGLKGPRGLPLIGNLAQIRKNAAEQYRIWSRTHG
PVYQIQLGNIPVVVVNSAAAAKVLFGHNAQALSSRPEFYTFHKIVSNTAGTTIGTSPYSESLKRRRKGAASALNRPSVES
YISHLDVESRSFVDELYRYGNGGETPVDPMPMIQRLSLSLSLTLNWGVRVASQEEDLFAEITHVEEEISKFRSTTGNLQD
YIPLLRLNPFNSNSKVAKEMRDRRDRYLTALNRDLDDRMKKGIHKPCIQANVILDKEAKLNSEELISISLTMLSGGLDTV
TTLVAWSIGLLSQRPDIQEKAAKAIRDMYGHDQPLCDPMDDQRCAYVAALVRECLRYFTVLRLALPRTSIRDVVYNGTVI
PKGTVFFLNSWACNMDPEVWSDPEEFRPERWLEQPDAPLFTYGMGYRMCAGSLLANRELYLVFMRTLNGFRIEPLGETDW
HPVRGNSDPTSLVAIPKKYKVRFVPRDEKALAKALGR*
>CYP504B8 Uncinocarpus reesii
77% to CYP504B5
UREG_05702.1
MALVSIVSELNSSAITHPFRALAVLALLIPGVYVIFNEFVRAAARVPGLNGPKGFPLIGNLSQIRVNAAEQYRKWSKQYG
PVYQIQLGNIPVIVVNSAAAAKVLFGQNAQALSSRPEFYTFHKVVSNTAGTTIGTSPFSESLKRRRKGAASALNRPSVQT
YVPHLDLESKDFVAELMKYGKAGRVAVDPMPMIQRLSLSLALTLNWGIRMASQEEDLFAEITHVEDEISRFRSTTGNLQD
YIPLLRLNPFSVGSKKAAEMRDRRDKYLKYLNSGLEDRMAKNEHKPCIQANVMLDKEARLNNIELTSISLTMLSGGLDTI
TTLVAWSIALLAQRPDIQDKAAAAIKEYHSVDQPLCDAMDDQRCEYIVALVRECLRYYTVLRLALPRTSIKDITYQGKVI
PKGSVFFLNAWACNMDPDVWSDPEVFRPERWLEQPDAPMFTYGVGYRMCAGSLLANRELYLVFLRTLNCFRIEPDGKVEW
DPISGNSDPTSLVAIPKKYKVKFVPKKEKLLTEALENFVPVSA
>CYP504B9 Coccidioides immitis
91% to CYP504B8
CIMG_07204.2
MALSSFISALNSQAIAHPFHALGVLALLIPGIYVIANEFVRAAARVPGFKGPKGFPLIGNLAQIRVNAAEQYRRWSKKYG
PVYQIQLGNIPVIVVNSAAAAKVLFGQNAQALSSRPEFYTFHKVVSNTAGTTIGTSPFSESLKRRRKGAASALNRPSVQT
YVSHLDLESKDFVAELMKYGKAGRAAVDPMPMIQRLSLSLALTLNWGVRMASQEEELFAEITHVEDEISRFRSTTGNLQD
YIPLLRLNPFSVGSKKAAEMRDRRDKYLNYLNRGLEERMAKNEHKPCIQANVMLDKEARLNNVELTSISLTMLSGGLDTI
TTLVAWSIGMLAERPDIQDKAAAAIKQYHSIDKPLCDPTDDQSCEYIVALVRECLRYYTVLRLALPRTSIKDITYQGKVI
PKGSVFFLNAWACNMDPEVWSDPEIFRPERWLEQPDAPMFTYGVGYRMCAGSLLANRELYLVFLRMLNCFRIEPEGRIEW
DPIKGNSDPTSLVAIPKKYSVRFVPKKEKLLTEALENFIPLAA
>CYP504B10 Fusarium oxysporum
87% to CYP504B4 Nectria haematococca
FOXG_07489
MTIANLLVSLNNQVHENKGQSLLVTLLIGPLIYIFINELIRHNARISNLKGPSGLPLIGNIWDIHINAAEKYRAWAKKYG
PVYQIQLGNIPIVVVNSAAAARSIFGANAQALSSRPEFYTFHK
VLSDTAGTTIGTSPYSDSLKRRRKGAASALNRPSVAT
YVDHLDVETRDFVKELFEYGKGGSIPVDPMPMIQRLSLSLALTLNWGIRLKSQKDDLFSEITHVEEEISRFRSTTGNLQD
YIPLLRLNPFNLHSTKAREMRNRRDKYLTALNNGLDERIANGTYKPCIQANVIMDKEAKLNKDELTSISLTMLSGGLDTV
TTQVAWFVAYLSQHPEIQEKAVSEIRKFYSEKQPMCDEQDDQKCEYIVALVKESLRYYTVLRLALPRASIRDIVYEGVTI
PKGTVVFLNAWACNMDDQVWSDPEVFRPERWFEQPDAPLFTYGVGYRMCAGSLLANRELYLVYMRLLNSLKIEKSDEVDC
HPITGSLDPTSLVALPRRYKAIFKPRNPEALQKALAVEN
>CYP504B10 Fusarium verticillioides
98% to CYP504B10 Fusarium oxysporum = ortholog
FVEG_04417
MTIANLLVSLNNQVHENKGQSLLVTLLIGPLIYILINELIRHNARISNLKGPSGLPLIGNIWDIHI
NAAEKYRAWAKKYGPVYQIQLGNIPIVVVNSAAA
ARSIFGANAQALSSRPEFYTFHKVLSDTAGTTIGTSPYSDSLK
RRRKGAASALNRPSVATYVDHLDIETRDFVRELYEYGKGGNIPVDPMPMIQRLSLSL
ALTLNWGIRLKSQKDDLFSE
ITHVEEEISRFRSTTGNLQDYIPLLRLNPFNMHSAKAKEMRNRRDKYLTDLNNGL
DERIANGTYKPCIQANVIMDKEAKLNKDELTSISLTMLSGGLDTV
TTQVAWFVAYLSQHPEIQEKAVSEIRKFYSEKQPMCDEQDDQKCEYIVALVKESLR
YYTVLRLALPRASIRDIVYEGVTIPKGTVVFLNAWACNMDDQVW
SDPEVFRPERWFEQPDAPLFTYGVGYRMCAGSLLANRELYLVYMRLLNSLKIEKSDE
VDCHPITGSLDPTSLVALPRRYKAIFKPRNPEALQKALAVEN*
>CYP504B11 Fusarium oxysporum
63% to 504B9 Coccidioides immitis
FOXG_10783 revised with gc boundary at EXXR
motif
No ortholog found in Fusarium verticillioides
MLIAELFKALSNEAVTRPYQTAVTSVLVSFLAYIIVNEYVARSARLAAFDGPKRLPIVGNLHQLRSNAAEKYRKWAKTYG
PVYQIQLGNVPILLVNSASAARTVFGTNSSATASRPEFYTFHKLVSNTAGTTIGTAPYSESLKRRRKGAASALNRPAVET
YIPHLDLETKDFIAEAYKFGKAGKTEVDPLPLVQRLSLSLALTLNWGTRMPSSDSDLLREITHVEVEISRFRSTTDNLQD
YIPLLRLNPFSFGHKKAAEYRNRRDAYLGMLNRDLEERVSKGTHKPCIQANIMLDREAKLNDVEMMSISLTMLSGGFETF
STVTTWAIAYLATHPEIQDKAYKAITDLHGSKSPLCDPNDDQKCDYVRALVRESLR (2)
YFTVLRLSLPRATNKDFYYEGKFIPKGTVV
FLNSWACNMDDELWEDPEIFRPERWLEHPDHPMFTFGVGYRMCAGSLLANRELYLTFMRMIASFELSTRDEIDTNPLTGV
EDLTSLVSTPRKYRVTFKPRNDAVLKAAIAQGFDE*
>CYP504B12 Aspergillus clavatus
89% to CYP504B5
ACLA_026760
MAITAALSFVQYSILHYPLQSFAAAVLIVPFIYVIANEFIRASVRVPGFEGPRGLPLIGNLAQIRKNAAEQYRIWSKTYG
PVYQIQLGNIPVIVVNSAAAAKVLFGQNAQALSSRPEFYTFHKIVSNTAGTTIGTSPYSESLKRRRKGAASALNRPSVDS
YVSHLDVESKAFVAELYKYGHSGKTPVDPMAMIQRLSLSLSLTLNWGVRVASQEEDLFNEITHVEEEISKFRSTTGNLQD
YIPLLRLNPFSSNSRKAKEMRQRRDKYLGALNRDLDDRMEKGIHKPCIQANVILDKEAKLNSEELISISLTMLSGGLDTV
TTLVAWSICLLSRRPDIQEKAARAIHIMFTEDKPLCDSGDDQKCAYVAALVRECLRYYTVLRLALPRTSIRDITYDGKVI
PKGTVFFLNAWACNMDPEIWSDPEEFRPERWFEQPDAPMFTYGMGYRMCAGSLLANRELYLVFMRTLNSFRIEPHDDVDW
HPISGNSDPTSLVAIPKKYKVRFIPKNAKALARDLF*
>CYP504B13 Aspergillus terreus
85% to CYP504B5
ATEG_08499.1
MAIAAALASLQRSAVDHPLQSLAVAALLVPIIYVIINEFIRASARVPGFKGPRGLPLIGNLAQIRTNAAEQYRLWSKTYG
PVYQIQLGNIPVIVVNSAAAAKVLFGQNAQALSSRPEFYTFHKIVSNTAGTTIGTSPYSDSLKRRRKGAASALNRPSVES
YVSHLDVESKAFVAELLKYGDAGKTPVDPMAMIQRLSLSLALTLNWGVRVASQEEELFDEITHVEEEISKFRSTTGNLQD
YVPLLRLNPFSSNSQKAKEMRNRRDRYLNGLNRDLDDRMEKGIHKPCIQANVILDKEAKLNAEELTSISLTMLSGGLDTV
TTLVAWSIGMLAKRPDIQEKAFKAIGEFYGEDEPMCDAHDDQKCAYVAALVRECLRFFTVLRLALPRTSIRDITYNGAVI
PKGTVFFLNAWACNMDPEVWHDPEEFRPERWLEQPDAPMFTYGMGYRMCAGSLLANRELYLVFMRTLNSFRIESDEDINW
HPVKGNSDPTSLVAIPQKYKVRFVPRSEKVLAQVVA*
>CYP504B14 Mycosphaerella fijiensis
68% to CYP504B8 Uncinocarpus reesii
fgenesh1_pg.C_scaffold_22000145
MIGHTFDLLQRQALEHTLRTAIVLLICLPITYFLINEVIRYRARLPAFPGPRGLPVIGNIADIRYNAAEKYRQWSRRYGP
VYQIQLGNIPVIVVNNAQAAKTIFGNNSQALSSRPVFYTFHKVLSNTAGTTIGTSPFSDSLKRRRKGAASALNKPSVQTY
IPHLDIETLSFVREAFKYGDAGKTALDPMPLIQRLSLSLSLTLNWGTRMGDSENALFHEITEVEEAISRFRSTTGNLQDY
IPLLRLNPFSFGTRKAAEMRARRDVYLKKLNADLDSRMEKGTHKPCIQANVILDREASLTAEELTSISLTMLSGGLDTIT
TLLQWSIALLSQRPDIQTKAITEIRNLHPTLLCDENDDMKCEYIVALVKECLRYYTVLRLALPRSTVRDVTFENKLIPSG
TTMFLNAWACNMDEEIWGSDAEVFRPERWLEKPDAPLFTYGMGYRMCAGSLLANRELYLVLMRMLSCFEILPYGEVDVHP
VRGSCDPKSLVAMPERYQVRFVPRDGEGLRRVLEEKEGMGVFE*
>CYP504C1 Ustilago maydis 521, UM01424.1
predicted mRNA.
XM_399039
MRFELSSESLATVPLFVWLSATLVVGHILYTAVKRPKINLPGPR
GWPYVGNLFQLGEDAAQTYYKWSKRYGPVYKVQLGEREVIIINSAQASKELLTDLGSI
YISRPLFYTFHTVVSSTAGFTIGTSPWDESCKRKRRAAATALNRVAVQSYVPIIDRET
FSLVEDLYSAKGKAIAPFAYFQRLALNVSLSVNYGSRLDKISDELLQEIVEVETHVAN
FRSVSNSAADYLPIVRYVQMLVGGNNSFAAQIRARRDKYMRRLLEDLKARVKAGTDIP
CITGNIIRDPTAKLTDLELSSICLSMVSAGLDTLANTFIWSMGFLAKHPEIQEKAYSE
LSKVYQGQVPNSDSEQVEYITALHKECSRYFSVLKLALPKATISDSSYKGVNIPAGTT
VFLNAFAIHQDAERYGDVENFRPERFLEPGEENKQSHYSFGAGRRMCAGVHLANRELY
IAFCKVIHFFHIQLSDVEEEKHFDINPKTGCANPKGLSSTPKPFKVRFVPRHPAALEQ
WIESEREKTDLMASAA
>CYP504D1 Ustilago maydis 521, UM05074.1
predicted mRNA.
XM_402689
MNTTKLLGTGALSPSFVFDHDSGNAIFGLSSSTLVVLVAMIAVS
TLTLKSVLPGDRSINLPGPRGWPIVGSWFDLGNNWAEYFRQAAKEYGDVFKVHIGNRT
VVVVNSPKAAHILFNEHGSSLISRPWFYTFHGVLSKSSAFTIGTSAWSDSTKNKRKAA
ATALNRPAVQSYMPIIVEESLDAVRRILNDGNAGKNGIVPYSYFQRLALNTSFQVNYG
FRMGERDDGLFDEISEVIAKVASVRAVTGSLQDYVPLMRYLPANAKSKAAASYGLRRK
KFMSKLYEELEQRVNQGKDESCITGNILKDTESRKKLSRLEIDSICLSMVSAGLDTFA
NTMIWTIGFLAKHPEIQRKAQAELLAHYPNRELPHVDSEDLVYIHAMAKEASRLFNVF
RICLPRTNVSDVTYNNAVIPAGTTFFLNSWACNVDAEKFADPFEFKPERFMDKSASNA
HVENKMGGVETYAFGMGRRMCPGVFLALREIYTTLVFLTHFFDIAPDGEYDIDPLTAV
EDGRAFSVRPKPFKVRCTPRPGVDLSPVLDKQ
>CYP504E1 Nectria haematococca
e_gw1.40.25.1
Necha1/scaffold_40:1293-2938
86% to AAJN01000191.1
Aspergillus terreus
72% to XM_654859.1
Aspergillus nidulans (pseudogene)
45% to e_gw1.24.52.1, 45% to 504A1 Aspergillus
nidulans
46% to XM_743078.1 Aspergillus fumigatus
Change the gene model at the N-terminal
MLTAVAVALVTYVFYH (0)
FLYATDIPHIKGLPEIPGAVPVLGHLLQLGEDHASTCEKWWRQYNHSVFQI
KLGNTRAVVVNSFEDCKKMLLGNQNAVIDRPKLYTFHGVISSTQGFTIGSSPWDDSCRKKRKAAGTALGR
PALRNYYPMFDLESYCILRDMEKDSRNGEIEIDVRPYIQRYALNTTLTLCYGIRMDAVYDDLLREILHVG
SAISLLRSASENLQDYVPILRYLPNNEKNSRSKELRERRDAYLNLLLDKVRDMIKKGTDKPCISAAILKD
QETKLTGVEVSSICLSLVSGGFETIPGTLTSCLSSLSTKEGQLWQGRAYEDIKRHYPDVRDAWTSCYVEE
KIPYVNAIVKEAGRYYTVSSMSLPRKTVTEVNWNGASIPPKTMILINAQAGNH
(1)
DVDHFGPDGGKFNPERW
LKNLDPPTEAESVGLAHLSFGTGSRACSGQYIASRLLYAALVRLLSSYKIVASEEMPPNTDYVEYNQFKT
ALVAIPREFKVKLIPRDTAMTAECLSAAEERTKEHYKE*
>CYP504E2 Aspergillus terreus NIH2624
AAJN01000191.1
N-term not clear, does not match other related genes
ATEG_07913.1
MTTTHDTAFIPSLAYRIQDGQGSTILGIAGVIALLSYL (0)
189214
TTIATDIPFIKGLPEIPGAVPIFGHLLKLGDDHATVCEKWWRQYGHSVFQIRLGNTRAV 189390
189391
VVNSFEDCRKMLLGHQNAIIDRPTLYTFHGVISSTQGFTIGSSPWDASCRKKRKAAGTAL 189570
189571
GRPALRSYYPMFDLESYSIVRDLHRDSCDGEVELNVRPYIQRYALNTTLTLCYGIRMD 189744
189745
AVYDELLREILYVGSAISLLRSASENLQDYIPLLRYLPNNEKNARSKSLRERRDKYLDLL 189924
189925
LDKVRDMIKKGTDKPCISSAILKDEETKLNGVEVSSICLSLVSGGFETIPGTLTSAIGSL 190104
190105
STKEGQVWQDRAYEDIKRHYPDIRDAWTSCFVEEKVPYVNAIIKEAGRYYTVSAMSLPRK 190284
190285
TVTEVNWNGAIIPQKTMVLINAQAGNH (1)
190365
190412
DVDHFGPDGGKFDPERW
190463
LKTLDPPTERETSGLNHLSFGAGSRACSGQYIASRLLYAALVRILSSYKIVASETEPPNT 190642
190643
DYVDYNQFKTALVAIPRDFKVKLVPRDPGMTAECLETAELRTREHYKE* 190789
>CYP504E3 Phaeosphaeria nodorum
AAGI01000160.1
MEVLHLLQSLYCTPLGYVSLLALFGFCVASIYK (0)
15789
LLTRTEVPYIRGIPEIPGALPVTGHLTQLGDDHATICEKWWRQYGHSVFQVRLGNTRAV 15613
15612
IVSSFQDCKKILVSNPQGLIDRPKLYTFHGVISSTQGFTIGSSPWDESCRNKRKAASTTL 15433
15432
SKGMLKNYYEMFDLESYCIVRDLQRDSKGSALEVSIRPYIQRYALNTTLTLCYGIRMDA 15256
15255
VYDDLLREILHVGSAISLLRSASENYQDYIPILRYLPNNEKNRRSKELRERRDKYLNELL 15076
15075
DKVRNMIDKGTEKPCISAAILKDEETRLTGVEVSSICLSLVSGGFETIPGTLVSCIGSLS 14896
14895
TPEGQKYQETAYQEISKVYPDLEDAWSREFEKENVPYLNAIVKEAGRYYTVSNMSLPRKT 14716
14715
MSDVRWGEAIIPKGTMVLINAQAGNH (1)
DVDYWGPDAGTFNPERWLEPPHPSSIPSIF
14497
TEKPTSSTSHLSFGAGSRSCPGAAIASKLISAALFRILSLYKIEASSTEPPNTDYVEYNA 14318
14317
IKSALVAIPRDFKIKLTPRDETGDLAREVLRMGEERTKNFYKE 14189
>CYP504E4P
Aspergillus nidulans add to nomen.
AN2347.3 76% to CYP504E2
MKTDYDITA*TVSLSQGYSAVLLFILVTLYLLYKYTLATDIPHIKN
LPVIPGALPIFGHLLKLGGDHATV*
EKWWRQYGHSVFQIRLANTRVVVVKSFDDCRKMLLSHQNALIDRPKLYTSYCVISSTQGYTIDSSPWDEPCRKKRKAAGTALGRPALRNY
HPMFDLESCCILR
TDLYRDSKDGEAEVSVRPYLQRYALNTTLTLCYGIRMDEV
YDEVLSEILYAGSAISLLHSAAENLQDYISLLRYVPNNEKKARSK
TRDRRDKYLDLLTRVRKMIERGTDKPCISAAILKVKE
(gap 40 aa)
QAWQDHAYEDIKRWYPDLQDTWTAAVTEERV
TYINAIIKEAARYYTVSSMSLPRK
VTEINWNGAIIPPKTMILINAQAGNR
DIDHLGPTGNRFNPER*LSS
>CYP504E5 Aspergillus niger
gw1.9.669.1|Aspni1
84% to CYP504E1 aa 219-331
ERWWRQYGHSVFQIKLGNTRAVVFNSFEDCRTVLLGHQNAIIDRPKLYTFHGVISSTQGFTIGSSPWDDSCKRKRKAAGT
ALGRPALRNYHPMFDLESYCIVRDLFRDSKNGQPGSVTGASADPTRSYIKRGAPPPDIALPHLHQLSXQSTLFTPKMGSL
LTQDMMSVKGRVALVTGGSSGIGRMIAQPSYQGLVTNGAKAYIVALPGDPIDQTVQDLNACGIESGGSAEGYACDLSSKD
SIYQLAKSISQKETKLDMLISNAGIRRDPPIACNVLTATLAELQESMWSSRESDWADTFRINTTAHYFLSVAFLPLLAAA
AD
>CYP504E6 Aspergillus niger
e_gw1.112.2.1|Aspni1
84% to CYP504E2 aa 279-590
ISLLRSASENLQDYIPILRYAPNNEKTARSKELRERRDAYLNLLLNKVRDMIKKGTDKPCISAAILKDEETKLSGVEVSS
ICLSLVSGGFETIPGTLTSVIGSLSTPEGQIWQDRAYEDIKRYYADPGDAWLSSIHEEKVPYVNAIVKEAGRYYTVSSMS
LPRKTATEVNWNGAIIPPKTMILINAQAGNHDVDHFGPDAGKFDPERWLKSVDPPSEKEIQGLPHLSFGAGSRACSGQVI
AIRLLYTALVRILSSYKIVASEDQPPNTDYVEYNQFKTALVAIPRDFKVRLIPRDDVLTRQCLDAAELRTKE
>CYP504E7 Mgr054 Mycosphaerella graminicola
71% to CYP504E1 Nectria haematococca
gw.1.2625.1 revised N-term
MELPKTPESNTSTQITFIAGLGFLFWWIYK (0)
WSTRTDIPKIAGIFEVPNAWPIVGHLLALGDDHATVCEASSNPHSIFQIRLGNTRAVVVNSFDDAKRMLLGFQSAVIDRPKLY
TFHGVISSTQGFTIGSSPWDESCKVRRKAAGQTLGRPAMKTYRPMF
DLETYCIIRDVVRDNKGGDEYLEIRPYLQRYALN
TTLTLCYGIRMDSVWDDMLREVLEVGSAISLLRSASENYQDYIPILRYLPNNEKNRRSKSLRDRRDRYLNALLEKVKEMI
EMGADKPCVSAAILKDEDTKLSGVEVSSICLSLVSGGFETIPGTLTSCIGSLSTPEGQLFQDRAYEDIKRRYPSIEDAWT
TALDAEEVPYVNAIVKEAGRYYTVSSMSLPRKAAADIDWDGAIIPKGTMILINAQAANHSEEHFGPDAKTFNPERWLSSL
EPPQEAPSTGLQHHSFGAGSRACSGQYIASRMLYTALIRLISSFKIVASEEEPPNVDYIEYNQFKSALVAVPRDFKVQMV
PRDPGALEKCLALAEQRTED
>CYP504E8P
gw1.9.803.1|Mycgr3 N-term piece Mycosphaerella
graminicola
68% to 504E7 new seq. not in Steve
KellyÕs set
TDIKRINGIPEIPGAVPICVHLLKLGEDHASTCERWWRQYNHPVFQIRFGNTRAVVFNSFDACRDILVKHHSAVIDRPKL
YTFHGVINSTQGFTIGSSPWVASSKNKRKAAGTALARPALRDYHPMFDLESFCIVRDMHADSDCSNPQKEVSIRPYIQRY
ALNTTLTLCYGIRMNDIYDELLREILHVGSAIFLLRSASENLQDYIPALCYLPNNE*TARSKELRDRRDAYLDLLLNEVCEMIK
QGVDKPCISAAILKDEETKLAGVEVSSICLSLVSGGFETIPGTLTSCSDSLSTP
>CYP504E9P Mycosphaerella fijiensis
76% to CYP504E7 Mycosphaerella graminicola
synt_with_mycgr.1__200
MLGSDLETNLDFIT &
LTTSTDIPKISSIFEIPGAFPITGHLLELGDDHATVCE (0)
WQKYKKSVF*IRLGNTRAVVINSFEDCKRMLIGNQSAVIDRPKLYTFHR
LISSTQGFTIGSSPWDESCKNKRKAAGQTLGRPAMKGYQAMF (0)
DLETYTLIRDLVKDSSGDCGETYLNPR
PYLQRYALNTTLTLCYGIRMDSVWDDMLREILEVGSAISLLRSASENMQD*VP
(1)
ILRYLPNNEKNQRSKSLRDRRDKYFNELLDRVREMIQH
GTDKPCVSAAILKDEETKLTGVEVSSICLSLVSEGFETIPGTLTSCLGSLATPEGQVFQERAYEDLKRHYPNVEDAWKQC
LESEDIPYINAIVKEAGRFYTVSSTSLPRKAAVDIPWDGALIPKGTMILINAQAGNHEVGHWGADAATFNPERWLEELDP
PKEKASSGLQHLSFGAGSRACSGQHIASRLLYSALVRLLSSFRIVASPDEPPNTDYVDYNAIKSALVAIPRDFKVRLISR
DEEALESCLRSGENRTRDAYAERSHGSGGHGRKLYQ*
>CYP504F1 Nectria haematococca
fgenesh1_pg.scaffold_33000056
Necha1/scaffold_33:187197-188955
44% to 504B1
MNLIEYFLRKELSLPALLGYAIAISVIALLVYLAQNEFTRHSSRIKHLPGPRGWPVVGNLFQ
(0)
VPAETYRRWAQKHGPVFQIQLGNTTGVVVNSVDAAKKLFIGQRNAMNSRPTFHVFHGKVSKAVTSIGTSPWDESCKRR
RKLAAAGLNRPRVESYAPILNLESREFLRDLHNESKDGSIEIDFRQAVTRFSLNLSLTLNYGTRVSNVKS
LHDDPLLAEILYVESEISKFRDTSKNYANYIPLLRYLEPIASFLRLTSAPKSHAADIGRRRLEYNDVLLN
KLKDEVERGEDKPCIQGAVLREPESATLTRGELISVSLSMMA (0)
GADSNQPTIAWAILLLAHRPDIQEKAYH
AIKEAGVLDIPSNAYASSKVEYIDALTKEIARYFVVLKLALPKATYTDATWGPATIPPNTLVFLNSWACNR
(1)
DPELFTEPEVFAPERWLPGSPDYAAHQFSFGIGGRMCVASLLAHRALYTVFLHLVAQFQIFPA
SGTTDEEIDPLKG
LKGRSFVATPRGFRARFVPREGQNLETWLRSPDGDI*
>CYP504G1 Candida guilliermondii
PGUG_05169.1
38-39% to many CYP504 sequences, also 39% to
CYP5054A1 and 41% to CYP5054A2
MLLDLLFDFLNSYGYLLLVVSILIAAKSVFGAAYCTGIRKIKGIVEPPECEAFYGHLNVLGEDHATNLQTIGDRYNLKVF
QVRFGVERAVILHTFAEGFSWFVKNHQSALIDRPLFYTFHKLVSNTQGLTVGTSPWDENCKRRRLAITKYMTRTALQKIQ
DLIDLESCSFVKDIWRLTCEGSIGVDPHIAAQRMSFNITTMLCYAIRFDTIDSSLLLDILKIVSQVSSFRSTNNNLQDYV
PIYRYLPDKRREMAKEVSKKRDVWLNDFLNRAFERSEVRESFAGSMGTKKLSLEDLRSICVSLVSGGFETLASITSLLLA
QLSTENGKEWQETAYGELTDAYGNDGDKLWNSVTFEEKCPFVVALIRETLRHYPVIPLCPPRKTTREFEYEGAKIPKGVT
VILNCQAANHDKEHFGADADEFNPARWFDESLDINKPPFHFTFGAGSRACPGILLSHRALYATIGRMIFLFKIGPHGEKP
DLNYKTYAEDKTAQTWSPLPFKISLEPRGPVDKFLNRDHLQHLVELSYEHI
>CYP505A1
AB030037 Fusarium oxysporum CYP505
MAESVPIPEPPGYPLIGNLGEFTSNPLSDLNRLADTYGPIFRLR
LGAKAPIFVSSNSLINEVCDEKRFKKTLKSVLSQVREGVHDGLFTAFEDEPNWGKAHR
ILVPAFGPLSIRGMFPEMHDIATQLCMKFARHGPRTPIDTSDNFTRLALDTLALCAMD
FRFYSYYKEELHPFIEAMGDFLTESGNRNRRPPFAPNFLYRAANEKFYGDIALMKSVA
DEVVAARKASPSDRKDLLAAMLNGVDPQTGEKLSDENITNQLITFLIAGHETTSGTLS
FAMYQLLKNPEAYSKVQKEVDEVVGRGPVLVEHLTKLPYISAVLRETLRLNSPITAFG
LEAIDDTFLGGKYLVKKGEIVTALLSRGHVDPVVYGNDADKFIPERMLDDEFARLNKE
YPNCWKPFGNGKRACIGRPFAWQESLLAMVVLFQNFNFTMTDPNYALEIKQTLTIKPD
HFYINATLRHGMTPTELEHVLAGNGATSSSTHNIKAAANLDAKAGSGKPMAIFYGSNS
GTCEALANRLASDAPSHGFSATTVGPLDQAKQNLPEDRPVVIVTASYEGQPPSNAAHF
IKWMEDLDGNDMEKVSYAVFACGHHDWVETFHRIPKLVDSTLEKRGGTRLVPMGSADA
ATSDMFSDFEAWEDIVLWPGLKEKYKISDEESGGQKGLLVEVSTPRKTSLRQDVEEAL
VVAEKTLTKSGPAKKHIEIQLPSAMTYKAGDYLAILPLNPKSTVARVFRRFSLAWDSF
LKIQSEGPTTLPTNVAISAFDVFSAYVELSQPATKRNILALAEATEDKDTIQELERLA
GDAYQAEISPKRVSVLDLLEKFPAVALPISSYLAMLPPMRVRQYSISSSPFADPSKLT
LTYSLLDAPSLSGQGRHVGVATNFLSHLTAGDKLHVSVRASSEAFHLPSDAEKTPIIC
VAAGTGLAPLRGFIQERAAMLAAGRTLAPALLFFGCRNPEIDDLYAEEFERWEKMGAV
DVRRAYSRATDKSEGCKYVQDRVYHDRADVFKVWDQGAKVFICGSREIGKAVEDVCVR
LAIEKAQQNGRDVTEEMARAWFERSRNERFATDVFD
>CYP505A1
Fusarium oxysporum CYP505
98% to CYP505A1
Fusarium oxysporum AB030037, only 13 aa diffs
FOXG_04152
MAESVPIPEPPGYPLIGNLGEFTSNPLSDLNRLADTYGPIFRLRLGAKAPIFVSSNSLINEVCDEKRFKKTLKSVLSQVR
EGVHDGLFTAFEDEPNWGKAHRILVPAFGPLSIRGMFPEMHDIATQLCMKFARHGPRTPIDASDNFTRLALDTLALCAMD
FRFNSYYKEELHPFIEAMGDFLTESGNRNRRPPFAPNFLYRAANEKFYGDIALMKSVADEVVAARKASPSDRKDLLAAML
NGVDPQTGEKLSDENITNQLITFLIAGHETTSGTLSFAMYQLLKNPDAYSKVQKEVDEVVGRGPVLVEHLTKLPYISAVL
RETLRLNSPITAFGLEAIDDTFLGGKYLVKKGEIVTALLSRGHVDPAVYGNDADKFIPERMLDDEFARLNKEYPNCWKPF
GNGKRACIGRPFAWQESLLAMVVLFQNFNFTMTDPNYALEIKQTLTIKPDHFYINATLRHGMTPTELEHVLAGNGATSSS
THNIKAAANSDTKTGGSGKPMAIFYGSNSGTCEALANRLASDAPSHGFSATTVGPLDQAKQNLPEDRPVVIVTASYEGQP
PSNAAHFIKWMEDLNGNEMEKVSYAVFACGHHDWVETFHRIPKLVDSTLEKRGGTRLVPMGSADAATSDMFSDFEAWEDT
VLWPGLKEKYKISDEESGGQKGLLVEVSTPRKTSLRQDVEEALVVAEKTLTKSGPAKKHIEIQLPSAMTYKAGDYLAILP
LNPKSTVARVFRRFSLAWDSFLKIQSEGPTTLPTNVAISAFDVFSAYVELSQPATKRNILALAEATEDKATIQELERLAG
DAYQAEISPKRVSVLDLLEKFPAVALPISSYLAMLPPMRVRQYSISSSPFADPSKLTLTYSLLDAPSLSGQGRHVGVATN
FLSHLTAGDKLHVSVRASSEAFHLPSDAEKTPIICVAAGTGLAPFRGFIQERAAMLAAGRTLAPALLFFGCRNPEIDDLY
AEEFERWEKMGAVDVRRAYSRATDKSEGCKYVQDRVYHDRADVFKVWDQGAKVFICGSREIGKAVEDVCVRLAIEKAQQN
GRDVTEEMARAWFERSRNERFATDVFD
>CYP505A1
Fusarium verticillioides
98% to CYP505A1 Fusarium
oxysporum CYP505
FVEG_07269
MAESVPIPEPPGYPLIGNLGEFTSNPLSDLNRLADTYGPIFRLRLGAKAPI
FVSSNSLINEVCDEKRFKKTLKSVLSQVREGVHDGLFTAFEDEPNWGKA
HRILVPAFGPLSIRGMFPEMHDIATQLCMKFARHGPRTPIDASDNFTRLAL
DTLALCAMDFRFNSYYKEELHPFIEAMGDFLTESGNRNRRPPFAPNFLY
RAANEKFYNDIALMKSVADEVVAARKASPSDRKDLLAAMLNGVDPQTGEKL
SDENITNQLITFLIAGHETTSGTLSFAMYQLLKNPEAYSKVQKEVDEVV
GRGPVLVEHLTKLPYISAVLRETLRINSPISAFGLEAIDDTFLGGKYLVKK
GEIVTALLSRGHVDPAVYGSDADKFIPERMLDDEFARLNKEYPNCWKPF
GNGKRACIGRPFAWQESLLAMVVLFQNFNFTMTDPNYALEIQQTLTIKPVH
FYINATLRHGMTPTELEHVLAGSGGTSSSNHNIKSAANSDVKAGSGKPM
AIFYGSNSGTCEALANRLASDAPSHGFSATTVGPLDQAKQSLPEDRPVVIV
TASYEGQPPSNAAHFIKWMEDLDGNEMEKVSYAVFACGHHDWVETFHRI
PKLVDSTLEKRGGTRLVPMGSADAATSDMFSDFEAWEDTVLWPGLKEKYKI
SDEESGGQKGLLVEVSTPRKTSLRQDVEEALVVAEKTLTKSGPAKKHIE
IQLPSAMTYKAGDYLAILPLNPKSTVARVFRRFSLAWDSFLKIQSEGPTTL
PTNVAISAFDVFSAYVELSQPATKRNILALAEATEDKATIQELERLAGD
AYQAEISPKRVSVLDLLEKFPAVALPISSYLAMLPPMRVRQYSISSSPFAD
PSKLTLTYSLLDAPSLSGQGRHVGVATNFLSQLTAGDKLHVSVRASSEA
FHLPSDAEKTPIICVAAGTGLAPFRGFIQERAAMLAAGRTLAPALLFFGCR
NPEVDDLYAEEFERWEKMGAVDVRRAYSRAADKSEGCKYVQDRVYHDRA
DVFKVWDQGAKVFICGSREIGKAVEDVCVRLAIEKAQQNGKDVTEEMARAW
FERSRNERFATDVFD*
>CYP505A2 N.
crassa AABX01000234.1 cont3.292 NCU05185.1 (version3)
28427
MSSDETPQTIPIPGPPGLPLVGNSFDIDTEFPLGSMLNFADQY (1) 28555
28609
GEIFRLNFPGRNTVFV (0) 28656
28709
TSQALVHELCDEKRFQKTVNSALHEIRHGIHDGLFTARNDE
PNWGIAHRILMPAFGPMAIQNMFPEMHEIASQLALKWARHGPNQSIKVTD
DFTRLTLDTIALCSMDYRFNSYYHDDMHPFIDAMASFLVESGNRSRRPAL
PAFMYSKVDRKFYDDIRVLRETAEGVLKSRKEHPSERKDLLTAMLDGVDP
KTGGKLSDDSIIDNLITFLIAGHETTSGLLSFAFVQLLKNPETYRKAQKE
VDDVCGKGPIKLEHMNKLHYIAAVLRETLRLCPTIPVIGVESKEDTVIGG
KYEVSKGQPFALLFAKSHVDPAVYGDTANDFDPERMLDENFERLNKEFPD
CWKPFGNGMRACIGRPFAWQEALLVMAVCLQNFNFMPEDPNYTLQYKQTL
TTKPKGFYMRAMLRDGMSALDLERRLKGELVAPKPTAQGPVSGQPKKSGE
GKPISIYYGSNTGTCETFAQRLASDAEAHGFTATIIDSLDAANQNLPKDR
PVVFITASYEGQPPDNAALFVGWLESLTGNELEGVQYAVFGCGHHDWAQT
FHRIPKLVDNTVSERGGDRICSLGLADAGKGEMFTEFEQWEDEVFWPAME
EKYEVSRKEDDNEALLQSGLTVNFSKPRSSTLRQDVQEAVVVDAKTITAP
GAPPKRHIEVQLSSDSGAYRSGDYLAVLPINPKETVNRVMRRFQLAWDTN
ITIEASRQTTILPTGVPMPVHDVLGAYVELSQPATKKNILALAEAADNAE
TKATLRQLAGPEYTEKITSRRVSILDLLEQFPSIPLPFSSFLSLLPPMRV
RQYSISSSPLWNPSHVTLTYSLLESPSLSNPDKKHVGVATSYLASLEAGD
KLNVSIRPSHKAFHLPVDADKTPLIMIAAGSGLAPFRGFVQERAAQIAAG
RSLAPAMLFYGCRHPEQDDLYRDEFDKWESIGAVSVRRAFSRCPESQETK
GCKYVGDRLWEDREEVTGLWDRGAKVYVCGSREVGESVKKVVVRIALERQ
KMIVEAREKGELDSLPEGIVEGLKLKGLTVEDVEVSEERALKWFEGIRNE
RYATDVFD* 31858
>CYP505A3 Aspergillus oryzae
GenEMBL AB078738
MSTPKAEPVPIPGPRGVPLMGNILDIESEIPLRSLEMMADTYGP
IYRLTTFGFSRCMISSHELAAEVFDEERFTKKIMAGLSELRHGIHDGLFTAHMGEENW
EIAHRVLMPAFGPLNIQNMFDEMHDIATQLVMKWARQGPKQKIMVTDDFTRLTLDTIA
LCAMGTRFNSFYSEEMHPFVDAMVGMLKTAGDRSRRPGLVNNLPTTENNKYWEDIDYL
RNLCKELVDTRKKNPTDKKDLLNALINGRDPKTGKGMSYDSIIDNMITFLIAGHETTS
GLLSFAFYNMLKNPQAYQKAQEEVDRVIGRRRITVEDLQKLPYITAVMRETLRLTPTA
PAIAVGPHPTKNHEDPVTLGNGKYVLGKDEPCALLLGKIQRDPKVYGPDAEEFKPERM
LDEHFNKLPKHAWKPFGNGMRACIGRPFAWQEALLVIAMLLQNFNFQMDDPSYNIQLK
QTLTIKPNHFYMRAALREGLDAVHLGSALSASSSEHADHAAGHGKAGAAKKGADLKPM
HVYYGSNTGTCEAFARRLADDATSYGYSAEVESLDSAKDSIPKNGPVVFITASYEGQP
PDNAAHFFEWLSALKGDKPLDGVNYAVFGCGHHDWQTTFYRIPKEVNRLVGENGANRL
CEIGLADTANADIVTDFDTWGETSFWPAVAAKFGSNTQGSQKSSTFRVEVSSGHRATT
LGLQLQEGLVVENTLLTQAGVPAKRTIRFKLPTDTQYKCGDYLAILPVNPSTVVRKVM
SRFDLPWDAVLRIEKASPSSSKHISIPMDTQVSAYDLFATYVELSQPASKRDLAVLAD
AAAVDPETQAELQAIASDPARFAEISQKRISVLDLLLQYPSINLAIGDFVAMLPPMRV
RQYSISSSPLVDPTECSITFSVLKAPSLAALTKEDEYLGVASTYLSELRSGERVQLSV
RLSHTGFKPPTELSTPMIMACAGSGLAPFRGFVMDRAEKIRGRRSSGSMPEQPAKAIL
YAGCRTQGKDDIHADELAEWEKIGAVEVRRAYSRPSDGSKGTHVQDLMMEDKKELIDL
FESGARIYVCGTPGVGNAVRDSIKSMFLERREEIRRIAKEKGEPVSDDDEETAFEKFL
DDMKTKERYTTDVFA
>CYP505A3 Aspergillus flavus
99% to CYP505A3 Aspergillus oryzae 4 aa diffs
AFL2G_09091 revised
MSTPKAEPVPIPGPRGVPLMGNILDIESEIPLRSLEMMADTYGPIYRLTTFGFSRCMISSHELAAEVFDEERFTKKIMAG
LSELRHGIHDGLFTAHMGEENWEIAHRVLMPAFGPLNIQNMFD
(1)
EMHDIATQLVMKWARQGPKQKIMVTDDF
TRLTLDTIALCAMGTRFNSFYSEEMHPFVDAMVGMLKTAGDRSRRPGLVNNLPTTENNKYWEDIDYLRNLCKELVDTRKE
NPTDKKDLLNALINGRDPKTGKGMSYDSIIDNMITFLIAGHETTSGLLSFAFYNMLKNPQAYQKAQEEVDRVIGRRRITV
EDLQKLPYITAVMRETLRLTPTAPAIAVGPHPTKNHEDPVTLGNGKYVLGKDEPCALLLGKIQRDPKVYGPDAEEFKPER
MLDEHFNKLPKHAWKPFGNGMRACIGRPFAWQEALLVIAMLLQNFNFQMDDPSYNIQLKQTLTIKPNHFYMRAALREGLD
AVHLGSALSASSSEHADHAAGHGKAGAAKKGADLKPMHVYYGSNTGTCEAFARRLADDATSYGYSAEVDSLDSAKDSIPK
NGPVVFITASYEGQPPDNAAHFFEWLSALKGDKPLDGVNYAVFGCGHHDWQSTFYRIPKEVNRLVGENGANRLCEIGLAD
TANADIVTDFDTWGETSFWPAVAAKFGSNTQGSQKSSTFRVEVSSGHRATTLGLQLQEGLVVENTLLTQAGVPAKRTIRF
KLPTDTQYKCGDYLAILPVNPSTVVRKVMSRFDLPWDAVLRIEKASPSSSKHISIPMDTQVSAYDLFATYVELSQPASKR
DLAVLADAAAVDPETQAELQAIASDPARFAEISQKRISVLDLLLQYPSINLAIGDFVAMLPPMRVRQYSISSSPLVDPTE
CSITFSVLKAPSLAALTKEDEYLGVASTYLSELRSGERVQLSVRPSHTGFKPPTELSTPMIMACAGSGLAPFRGFVMDRA
EKIRGRRSSGSMPEQPAKAILYAGCRTQGKDDIHADELAEWEKIGAVEVRRAYSRPSDGSKGTHVQDLMMEDKKELIDLF
ESGARIYVCGTPGVGNAVRDSIKSMFLERREEIRRIAKEKGEPVSDDDEETAFEKFLDDMKTKERYTTDVFA*
>CYP505A4 Magnaporthe grisea MG05401.4 53% to CYP505A2 AACU01000504 cont2.993
MSHNHNPRANNRRGSIREKLKMGTAKNPPKAVPEQDDDEDVKLVPIPQPS
RAPFVGNLPDLDVKFPLDSMVNLANKYGSIFKLDLPGLEFVTVSDWDLVH
EVCDDSRFKKSIKGDLEELRNAVHDGLFTSSGEDEENWGIAHRVLMTAFG
PLSIRNMFDEMHEVASQLALKWARQGPHEPLDVSGDTTRLALDTVALCSM
GFRFNSYYRQDLHPFIKAMNEVLDEAGRRANRFMPSVFYHSHNKKFRENI
KLLRTTAREVLDARKTQKGPEKRRDLLTAMLDGVDPKTGKKMTDESIIDN
LITFLVAGHETTAATLSFALYNLAKFPEVSRKAQKEVDDVVGKGAVKLEH
VPKLKYISALIRETLRLNAPITAFGREAIGDQVLGGKYLLKDKTQIVCFL
TKSQSDPVIWGPDADEFKPERMLDDSFDRMQKKHPHCWAPFGTGVRGCIG
RPFAWQEMVLCLAVLLQNYNFVMYNPAYALRLAQSLTIRPKDLYLRAISR
>CYP505A5 Magnaporthe grisea MG01925.4 55% to 505A2 AACU01000373 cont2.362
MAATQSRDWASFGVSLPSTALGRHLQAAMPFLSEENHKSQGTVLIPDAQG
PIPFLGSVPLVDPELPSQSLQRLARQYGEIYRFVIPGRQSPILVSTHALV
NELCDEKRFKKKVAAALLGLREAIHDGLFTAHNDEPNWGIAHRILMPAFG
PMAIKGMFDEMHDVASQMILKWARHGSTTPIMVSDDFTRLTLDTIALCSM
GYRFNSFYHDSMHEFIEAMTCWMKESGNKTRRLLPDVFYRTTDKKWHDDA
EILRRTADEVLKARKENPSGRKDLLTAMIEGVDPKTGGKLSDSSIIDNLI
TFLIAGHETTSGMLSFAFYLLLKNPTAYRKAQQEIDDLCGREPITVEHLS
KMPYITAVLRETLRLYSTIPAFVVEAIEDTVVGGKYAIPKNHPIFLMIAE
SHRDPKVYGDDAQEFEPERMLDGQFERRNREFPNSWKPFGNGMRGCIGRA
FAWQEALLITAMLLQNFNFVMHDPAYQLSIKENLTLKPDNFYMRAILRHG
>CYP505A6 Magnaporthe grisea MG10879.4 59% to 505A2 AACU01001802 cont2.2099
MATSDDQTVPIPEPQGLPLLGNIGAIDNEFPLGSLLSMASKYGEIWRMRF
PGRSLVFVSTQALVNEVCDEKRFYKSINPTLKEVRGGTHDGLFTAYPDEE
NWGIAHRILMPAFGPLSIRSMYDEMHDIASQLALKWARYGSNSPIMVTDD
FTRLTLDTLALCSMGFRFNSYYSTEMHPFIDAMADFLVECGTRGRRPPLP
SIFYRTQDQKFDSDIEILRKTAREVLEARKAGEGADRRDLLHAMLSGVDS
KTGKKMTDESIMDNLITFLIAGHETTSGLLSFVFYELMKHPEFYEKAQRE
VDEVCGKGPITVEHMSKLPYLNAVLRETLRVHATIPNITVAAREDDVLGG
KYKVSKDEVIVLLLAKSQVDPRVWGKDADEFVPERMLDENFERITKEFPN
SWKPFGNGMRACIGRPFAWQEALLVMAMLLQNFNFVLAPNYQYALKQTLT
LKPKDLYMRAILR
>CYP505A7 Fusarium graminearum FG01972.1
AACM01000107 FGcontig1.107_scaffold1
MAESVPIPEPPGYPLIGNLGEFKTNPLNDLNRLADTYGPIFRLHLGSKTP
TFVSSNAFINEVCDEKRFKKTLKSVLSVVREGVHDGLFTAFEDEPNWGKA
HRILIPAFGPLSIRNMFPEMHEIANQLCMKLARHGPHTPVDASDNFTRLA
LDTLALCAMDFRFNSYYKEELHPFIEAMGDFLLESGNRNRRPAFAPNFLY
RAANDKFYADIALMKSVADEVVATRKQNPTDRKDLLAAMLEGVDPQTGEK
LSDDNITNQLITFLIAGHETTSGTLSFAMYHLLKNPEAYNKLQKEIDEVI
GRDPVTVEHLTKLPYLSAVLRETLRISSPITGFGVEAIEDTFLGGKYLIK
KGETVLSVLSRGHVDPVVYGPDAEKFVPERMLDDEFARLNKEFPNCWKPF
GNGKRACIGRPFAWQESLLAMALLFQNFNFTQTDPNYELQIKQNLTIKPD
NFFFNCTLRHGMT
>CYP505A8 Aspergillus nidulans AN6835.1 55%
to 505A1 505 clan
MAEIPEPKGLPLIGNIGTIDQEFPLGSMVALAEEHGEIYRLRFPGRTVVV
VSTHALVNETCDEKRFRKSVNSALAHVREGVHDGLFTAKMGEVNWEIAHR
VLMPAFGPLSIRGMFDEMHDIASQLALKWARYGPDCPIMVTDDFTRLTLD
TLALCSMGYRFNSYYSPVLHPFIEAMGDFLTEAGEKPRRPPLPAVFFRNR
DQKFQDDIAVLRDTAQGVLQARKEGKSDRNDLLSAMLRGVDSQTGQKMTD
ESIMDNLITFLIAGHETTSGLLSFVFYQLLKHPETYRTAQQEVDNVVGQG
VIEVSHLSKLPYINSVLRETLRLNATIPLFTVEAFEDTLLAGKYPVKAGE
TIVNLLAKSHLDPEVYGEDALEFKPERMSDELFNARLKQFPSAWKPFGNG
MRACIGRPFAWQEALLVMAMLLQNFDFSLADPNYDLKFKQTLTIKPKDMF
MKARLRHG
>CYP505A9 Nectria haematococca
fgenesh1_pg.scaffold_12000374 [Necha1:90392]
Necha1/scaffold_12:985898-989367
77% to 505A7, 79% to 505A1
MAESVPIPEPPGYPLIGNLGEFTTSPLADLKRLADTY (1)
GPIFRLRLPGKSPIFAANNAFVNELCDEKRFQKTLKSVLG (0)
TVREGVHDGLFTAYNDEPNWGKAHRILLPAFGPLSIRSMFDEMHDIATQMCMKFARHGPQTPI
NASDDFTRLALDTLALCSMGFRFNSYYREELHPFIQAMGDFLTESGVRNRRPTFAPNFLYRAANEKFLAD
IKVMKDLAAEVVANRKERPNDRKDLLTAMLEGVDPQTGEKLSDDNIGNQLVTFLIAGHETTSGTLAFSFY
NLLKHPEAYEKAQQEVDQVIGRGPITVEHLTKLPYLSA (0)
ILRETLRLNSPIPGFGVEAIEDTFLGGKYLVKKGEIVSCMLSKAHLDPVVYGEDAEAFRPERMLDENFER
LQKEHSNCWKPFGNGKRACIGRPFAWQEALLALAMLLQNFNFTMDDSNYQLQIQETLTIKPKHFNMRATL
RYGMTPTELERVLAGRGADSHATSGTKSSAAAGTKGAGGKPISIYYGSNSGTCEALAQRLASDAPGHGFA
AKNIGPLDEAKQNLPEDHPVVIVTASYEGQPPSNAAHFINWMERLNGQEMEKVSYAVFACGHHDWVETFH
RIPKLVDATLEKRGGTRLVPMGSADAAVSDMFSDFEAWEDETLWPALKEKYGGDGGDSQAGSQRGLLVEL
STPRKTRLRQDVEEALVVSEKTLTASGPPKKNIEIQLPTGMTYKAGDYLAILPLNPKTTVGRVFRRFKLA
WDVFLKIHSEGPTTLPTDTEISAYDVFSAYVELSQPATKR (0)
NILALVEATEDKAVIEELEKLTGDAYAEEISAKKVSVLDLLEKYPAVALPISSYLGMLPPMRVRQY
(2)
SISSSPLANSSKLTLTYSLLDEPSLSGQGRHVGVATHFLSSLSAGEKLHVSVRPSVAAFHLPSDAE
NTPLICIAAGTGLAPFRGFVQERAAMLAAGRNLAPAMLFFGCRNPDIDDIYADEFDRWEKMGAVSVRRAY
SRATDKSEGCKYVQDRLYHDRADVFKLWDQGAKVYICGSREVGKAVEAVCVRLVVEWSEEHMECTSTEEK
AREWFEKHRNERFATDVFD*
>CYP505A10P Nectria haematococca
fgenesh1_pg.scaffold_160000001
Necha1/scaffold_160:4628-11288
MAETAPIPEPPSYPLIGNWGEFTTTPATDFNRLAVTY (1)
>CYP505A11 Nectria haematococca
fgenesh1_pg.scaffold_53000030 [Necha1:96758]
Necha1/scaffold_53:84132-87603
59% to 505A7, 60% to 505A1
58% to fgenesh1_pg.scaffold_12000374
MAETVEIPTPAGLPLLGNIKSIDPEFPLGSMVSLAEQH (1)
GEIYRLKFPGRTVVIVSTQALVNETCNEKRFKKCVNSALT (0)
EIREGVHDGLFT (0)
AKLGEENWGIAHRVLMPAFGPLSIQRMFDEMHDIASQLALKWARYGPDSP
IMVTDDFTRLTLDTLALCSMGYRFNSYYSPVLHPFIEAMGDFLTEAGEKPRRLPLPGIVYRERDRKYQQD
IETMRSTAKEVLDARKAGGSTRKDLLTAMLEGVDTKTGKKMTDESIMDNLITFLIAGHETTSGLLSFAFY
QLLTHPEAYQLAQKEVDQVVGKGPIQVGHLSKLPYLNGVLRETLRINATIPLFTVEAFEDTLLGGKYPVK
AGETILNLLAKSQLDPTVFGDDANEFKPERMFDDNFARLNKEFPNSWKPFGNGMRACIGRPFAWQEALLV
MVMLLQNFNFVLDPSYELGFKQTLTIKPKDMHMRAILRDNLTPTSLERRLAGLPVSEREEANGVNGKSSD
AKDGVPMTVLYGSNSGTCESLAQRVATDAAEHGFHVTKIDCLDTANGNLPTDQPVVIVTASYEGQPPDNA
GHFVAWVEKADQETKPLEGVSYAVFGCGHKDWVQTFHRIPKLVDSNLEQLGATRLVNIGLTDASENMVFS
DFEAWEDNILWPALEARYNPESKKSSADKGLSVKSSNFRTLTLRQDVKEATVVETKVLTSSTDTKSKKRH
IEVELPEGTQYTAGDYLAVLPINPQEVVRRALRRFKLPMDAHLEISSSTPTVLPTDTSVSALDVLSSYVE
LSQPATKR (0)
NLLAIAEAASNEDTKAALTSLSEERYVEEISNKRVSVLELLERYPSVDLPIGDFLQMLPSIRIRQY
(2)
SISSSPLWNQSRATITFSVLKGPASSGQGIYNGVATSYLDSLADGDTLQVAIRSSPAAFSLPSNPE
QTPIICIAAGSGLAPFRGFIQQRAIMIESGRKLAPGLLFFGCRAPDQDDLYHDEFDVWQKLGAVDVRRAY
SRHGDGCKHVQDRIWQDKEDFIQLWEKGATVYVCGSRAVADSVREVMIKLKTEMEKRSGGEMGLEEAKKW
FDEQRNVRYVMDVFD*
>CYP505A12 Nectria haematococca
fgenesh1_pg.scaffold_23000101 [Necha1:93347]
Necha1/scaffold_23:253431-256834
57% to 505A7, 56% to 505A1
57% to fgenesh1_pg.scaffold_12000374
Note: unusual exon 1 codes for 2 amino acids,
this matches with
other CYP505 sequences.
MP (2)
NITPIPEPPALPWLGHIAEFKSEDSLQDLTRLHEIY (1)
GDIYRLRFPEGKSYILLGSNKLVNEVCDETRF
QKSINNELWEVRNLANDGLFTAKPGEENWGIAHRVLMPAFGPVNIRGMFDEMYDIATQLALKWARHGPSQ
AILAADDFTRLAFDTIALCSMDFRFNSFYRDKAHPFISSMGDVLTESGKRFQRPSVAKVFYRAITKKYFQ
DIKMMREVADEVVAARRANPDSKKKDLLAAMMNGVDPKTGKKMNDVSITDNLITFLVAGHETTSGTLSFL
FYSLLKNPDCYQKAQKEVDDIMGKEPITAEKIFKLRYIPA (0)
ALRETLRVCSPIPGVGMEALKDTLLDYKYP
IAKGDVLSPFLTVAHLDPRVFGEDAHLFRPERMLDENFERLQKEHPNCWKPFGNGVRACIGRPFAWQEML
LAVALLLQNFNISMDDPGYNLRIAETLTVKPKDFYIRASLRHGMSPLDLEHKLRGTTAEPVAATNGAAKD
EKHQVLESDGKRISIFYGSNSGTCESLAQRLAADAFSHGFTASCIESLDVAKENLPTNQPVVIITSSYEG
QPPDNAAHFVSWLKNLEGKPLDKVSYAVFGVGHREWSATFHKVPKLVNTELEDHGAKRVAEIGLTDTSDR
DPFTDFETWEDNILWPALQKEGPDSEPKFAIPQSDLSVCVSMPRSSTLRQDVNEAIVTATRDLSGPGVPL
KKHFEIALPSEVSYRAGDYLCILPINPRETVSRVFRHFKLSWDAVLTIEGEKRVALPMSQPTSAWNVLSA
YVELAQPATKRNILSLAEYTADGETKRSLQDLAGENLQEEVTKKRVSVMDLLERFPKIELPLAPFLTMLP
PMRIRQY (2)
SIASSPLKSPHHVSVTYSILDEPSLSGQGRHIGVATSYLSNLSTNDLVHVAIRPSHVAFHLPL
TPETTPIICVAAGAGVGPFRAFIEERAQQMAAGRKLAPALLFFGCRGKTDDLYREEFDAWEKQGAVIVKR
AYSRETSEETKNCKYVQHRMVEEKHEVAELWDRGAKLYVCGSRDMGKAVEEACVGLLQELNDMSEKEARM
FVEEVRNQRFATDVFT*
>CYP505A13 Aspergillus fumigatus Af293
GenEMBL XP_754698.1 also EAL92660.1
fatty
acid hydroxylase predicted
60% to
505A8
MSESKTVPIPGPRGVPLLGNIYDIEQEVPLRSINLMADQYGPIYRLTTFGWSRVFVSTHELVDEVCDEER
FTKVVTAGLNQIRNGVHDGLFTANFPGEENWAIAHRVLVPAFGPLSIRGMFDEMYDIATQLVMKWARHGP
TVPIMVTDDFTRLTLDTIALCAMGTRFNSFYHEEMHPFVEAMVGLLQGSGDRARRPALLNNLPTSENSKY
WDDIAFLRNLAQELVEARRKNPEDKKDLLNALILGRDPKTGKGLTDESIIDNMITFLIAGHETTSGLLSF
LFYYLLKTPNAYKKAQEEVDSVVGRRKITVEDMSRLPYLNAVMRETLRLRSTAPLIAVHAHPEKNKEDPV
TLGGGKYVLNKDEPIVIILDKLHRDPQVYGPDAEEFKPERMLDENFEKLPKNAWKPFGNGMRACIGRPFA
WQEALLVVAILLQNFNFQMDDPSYNLHIKQTLTIKPKDFHMRATLRHGLDATKLGIALSGSADRAPPESS
GAASRVRKQATPPAGQLKPMHIFFGSNTGTCETFARRLADDAVGYGFAADVQSLDSAMQNVPKDEPVVFI
TASYEGQPPDNAAHFFEWLSALKENELEGVNYAVFGCGHHDWQATFHRIPKAVNQLVAEHGGNRLCDLGL
ADAANSDMFTDFDSWGESTFWPAITSKFGGGKSDEPKPSSSLQVEVSTGMRASTLGLQLQEGLVIDNQLL
SAPDVPAKRMIRFKLPSDMSYRCGDYLAVLPVNPTSVVRRAIRRFDLPWDAMLTIRKPSQAPKGSTSIPL
DTPISAFELLSTYVELSQPASKRDLTALADAAITDADAQAELRYLASSPTRFTEEIVKKRMSPLDLLIRY
PSIKLPVGDFLAMLPPMRVRQYSISSSPLADPSECSITFSVLNAPALAAASLPPAERAEAEQYMGVASTY
LSELKPGERAHIAVRPSHSGFKPPMDLKAPMIMACAGSGLAPFRGFIMDRAEKIRGRRSSVGADGQLPEV
EQPAKAILYVGCRTKGKDDIHATELAEWAQLGAVDVRWAYSRPEDGSKGRHVQDLMLEDREELVSLFDQG
ARIYVCGSTGVGNGVRQACKDIYLERRRQLRQAARERGEEVPAEEDEDAAAEQFLDNLRTKERYATDVFT
>CYP505A13 Neosartorya fischeri
97% TO CYP505A13 Aspergillus fumigatus = ortholog
NFIA_067930
MSESKTVPIPGPRGVPLLGNIYDIEQEVPLRSINLMADQYGPIYRLTTFGWSRVFVSTHELVDEVCNEERFTKVVTAGLN
QIRNGVHDGLFTANFPGEENWAIAHRVLVPAFGPLSIRGMFDEMYDIATQLVMKWARQGPTVPIMVTDDFTRLTLDTIAL
CAMGTRFNSFYHEEMHPFVEAMVGLLQGSGDRARRPALLNNLPTSENAKYWNDITFLRNLAQELVEARRKNPEDKKDLLN
ALILGRDPKTGKGLTDESIIDNMITFLIAGHETTSGLLSFLFYYLLKTPHAYKKAQEEVDSVIGRRKITVEDMSKLPYLN
AVMRETLRLRSTAPLIAVHAHPEKNKEDPVTLGGGKYILNKDEPIVIILDKLHRDPQVYGPDAEEFKPERMLDENFEKLP
KNAWKPFGNGMRACIGRPFAWQEALLVVAILLQNFNFQMDDPSYDLHIKQTLTVKPKDFHMRATLRHGLDATKLGIALSG
TADSAPPESSGAASRVRKQAAPPPGQLKPMHIFFGSNTGTCETFARRLADDAVGYGFAADVQSLDSAMQNVPKDEPVVFI
TASYEGQPPDNAAHFFEWLSALKENELEGVNYAVFGCGHHDWQATFHRIPKAVNQLVAEHGGNRLCDIGLADAANSDMFT
DFDSWGESAFWPAITSKFGGGKSDEPKSSSSLQVEVSTGMRASTLGLQLQEGFVVDNQLLSAPDVPAKRMIRFKLPSDMS
YRCGDYLAVLPVNPSSVVRRAIRRFDLPWDAMLTIRKPSHAPKGSTSIPLDTPISAFELLSTYVELSQPASKRDLTALAD
AAVTDADVQAELRYLASSPTRFTEEIVKKRMSPLDLLIRYPSIKLPVGDFLAMLPPMRVRQYSISSSPLADPSECSITFS
VLNAPSLAAASLPPAERAEAEQYMGVASTYLSELKPGERAHIAVRPSHSGFKPPMDLKAPMIMACAGSGLAPFRGFIMDR
AEKIRGRRSSVGADGQLPEVEQPAKAILYVGCRTKGKDDIHAAELAEWAQLGAVDVRWAYSRPEDGSKGRHVQDLMLEDR
EELVSLFDQGARIYVCGSTGVGNGVRQACKDIYLERRRQLRQEARERGEEVPAEDDEDAAAEQFLDNLKTKERYATDVFT*
>CYP505A14 Aspergillus oryzae
GenEMBL
BAE56245.1
61% TO
505A3
revised
3/19/2009
MEETKLIPIPEPRGLPLLGNILDVDSEAPEKSFQRLAETYGPIFRLNLAGASRVFISTYELVDEICDEER
FTKVVTAGLREIRNGVQDGLFTADYPGEDNWAIAHRVLVPAFGPLMIRAMYEDMYDIASQLALKWARQGS
SATIMANDDFTRLTLDTIALCSMGTRFNSFYSEDLHPFIKAVATLLQGSSDRTFRSTLLNNLPTRENKKY
WSDISLLRTLSQELVDARRNNPIDKKDLLNALILGQDLQTGQHLSDDSIINNMITFLVA
(1)
GHETTSATLTFLFYYLLKNPHAYQRAQEEVDTVVGQRKIIVEDLSKLPYIAASLRETLRLQAPVPLIAFHPHPTK
NHEDPVTLGKGKYALNNDEPVVLIMGKVHRDPKVFGDDAEEFKPERMLDKNFEDLPKNAWKPFGNGMRGC
IGRPFAWQEMLLVVAMLLQNLNFEMENPSYDLRIKQSLSIKPDGFQMKATLRRGLDAAKLASVLNSGGDL
LSHAPQILNGEYKPNTDLRFHLRPMHIFFGSNTGTCEALARRLAKDSMGYGFATRVESLNSAMENIPRDN
PVIFITATYEGQPPDNAAHFFEWLNGLKKAELDGVNYCVFGCGHHDWSATFLRIPKATNDLIEKHGGTRL
CDMGMADAANSDMFSDFDTWSELILWPAINLKFGRASSEGDVQSKSALHVDVSSSMRAFTLGLQLQEGYV
LENKLLTTPDVPAKRMLRFKLPPDTTYQCGDYLIVLPVNPAHVVCRAIRRFNISWDSMLTVRKPSHASDG
ITNMPLETPISAFELFSTYVELSQPASKRDLITLADAATTDTDAQAELQSLASSPNRFTEEVINNRLSPL
DILIRHPSINLPLSTFLEMLPPLRARQYSISSSPLASRSDCTITFSVLNSPHLSTENKRFVGVASTYLSE
LQAGDRVQISIRASNNKGFKPPLKEETPMIMACAGSGLAPFRGFIMDRAERIRGRGTELLSDDDHPEIGK
PARAILYIGCRTKGKDDIHASELDEWTRQGAVDVRWAYSRPTDRSQGRHVQDLLFEDRNELLELIDQGAR
IYVCGGMSVGQGIRQVFKDMFIERCREVLENGSDGDEDVAAEEYLDSLKTEERYATDVFT
>CYP505A14 Aspergillus flavus
99% to CYP505A14 Aspergillus oryzae
AFL2G_01234
MEETNLIPIPEPRGLPLLGNILDVDSEAPEKSFQRLAETYGPIFRLNLAGASRVFISTYELVDEICDEERFTKVVTAGLR
EIRNGVQDGLFTADYPGEDNWAIAHRVLVPAFGPLMIRAMYEDMYDIASQLALKWARQGSSATIMANDDFTRLTLDTIAL
CSMGTRFNSFYSEDLHPFIKAVATLLQGSSDRTFRSTLLNNLPTRENKKYWSDISLLRTLSQELVDARRNNPIDKKDLLN
ALILGQDLQTGQHLSDDSIINNMITFLVAGHETTSATLTFLFYYLLKNPHAYQRAQEEVDTVVGQRKIIVEDLSKLPYIA
ASLRETLRLQAPVPLIAFHPHPTKNHEDPVTLGKGKYALNNDEPVVLIMGKVHRDPKVFGDDAEEFKPERMLDKNFEDLP
KNAWKPFGNGMRGCIGRPFAWQEMLLVVAMLLQNLNFEMENPSYDLRIKQSLSIKPDGFQMKATLRRGLDAAKLASVLNS
GGDLLSRAPQILNGEYKPNTDLRFHLRPMHIFFGSNTGTCEALARRLAKDSMGYGFATRVESLNSAMENIPRDNPVIFIT
ATYEGQPPDNAAHFFEWLNGLKKAELDGVNYSVFGCGHHDWSATFLRIPKATNDLIEKHGGTRLCDMGMADAANSDMFSD
FDTWSELILWPAINLKFGRASSEGDVQSKSALHVDVSSSMRASTLGLQLQEGYVLENKLLTTPDVPAKRMLRFKLPPDTT
YQCGDYLIVLPVNPAHVVCRAIRRFNISWDSMLTVRKPSHASDGITNMPLETPISAFELFSTYVELSQPASKRDLITIAD
AATTDTDAQAELQSLASSPNRFTEEVINNRLSPLDILIRHPSINLPLSTFLEMLPPLRVRQYSISSSPLASQSDCTITFS
VLNSPHLSTENKRFVGVASTYLSELQAGDRVQISIRASNNKGFKPPLKEETPMIMACAGSGLAPFRGFIMDRAERNRGRR
TELLSDDDHPEIGKPARAILYIGCRTKGKDDIHASELDEWTRQGAVDVRWAYSRPTDRSQRRHVQDLLFEDRNELLELID
QGARIYVCGGMSVGQGIRQVFKDMFIERCREVLENGSDGDEDVAAEEYLDSLKTEERYATDVFT*
>CYP505A15 Aspergillus niger
fgenesh1_pm.C_scaffold_7000162|Aspni1
72% to CYP505A13
MGSVKPVPIPGPKGVPFLGNVYDIDQEMPVRSFELMADQYGPIYRLTTFGLSRVVVSTQELVDEVCNEERFAKSVDGGLG
QLRNLLHDGLFTARYPGEENWALAHRVLIPAFGPLSIRGMFDEMQDIANQLVMKWARQGPETPIVVTEDFTRLTLDSIAL
CAMGTRFNSFYHDSMHPFVEAMVGGMQVASYRAQRPSFLNQLPTSENNAFWNDISYMRNLAKELIEDRRKHPSDKKDLLN
ALILGRDPQSGKGLSDESIIDNMITFLIAGHETTSGMLSFVFYYLLKNAHAYKKAQEEVDRVIGRRKITVDDLSKLPYIN
AVMREALRLNPPASVMRVHAHPTKNKEDPVTLGNGRYVLNKDEPITVLLPKLHRDPKVYGADAEEFKPERMLDENFNSLP
RNSWKPFGNGMRGCIGRPFAWQEGLLAIALLLQNFNFQLDDPSYDLRIKQTLTIKPKDFKMRATLRHGLDPITLEPALNS
GSVPRESSTVASRERKKDAALSEGDMKPMHIFFGSNTGTCEALARRLADDAVAWGFSAKVNSLDSATENVPKGDPVVFIA
ASYEGQPADNAAHFFEWLSAANDNELEGINYAVFGCGHHDWTATFYRIPKAINELVKEHGGNRLCDIGLVDTAIADMFTD
FDNWSESALWPAISSKFGSKSQGQAGKKASSGLQVELSSEKRVTTLGLQLQEGYVIENKLLTAPDVSAKRLVRIKLPSDM
TYQCGDYLAVLPVNPTSIVRRAMRRFKLPWDAFLTVRKSSQTQNGPSAIPTDTPISAFALLSSYVELSQPASKRDLTALA
DAAVADEESQAELRYMANSPSRFNEEVVTKRLSLLDILDRYPSIGLPLGDFLAMLPPMRVRQYSISSSPLTDPTECSITV
SVLNAPSLSGTDEPYMGVASTYLSILQADERIHIAVRPSHSGFKPPADLNTPMIMACAGSGLGPFRGFVMDRAEKILSRS
DSITEKPAPAILYVGCRTKGKDDIHAEELAEWSRQGIVDVRWAYSRPSDGSVAQHIQDRITSDRDEVVSLFEQGARIYVC
GSAEVGKAVRQAFKNIYVDVKQERRRVALETKQEEVPSEVNDEDVEKFFDDLKASMRYATDVFT*
>CYP505A16 Fusarium oxysporum
57% to CYP505A12 Nectria haematococca
FOXG_17221, no ortholog in F. verticillioides
MALSCDESTPIPEPRGLPFLGNVTE
FRSEDSLQDLDRLHDTYGEIYRLRFPKVGSCVIVGSQKLVNELCDEKRFRKAIQAELAEIRLAAGDGLFTAREGEV
SWDIAHRVLMPVFGPTAIRSMFDEMYDVVSQMTLKWARYGPTSPISASEDFTRLALDTIALCSMGYRFNSFYKDTTHPFV
QSMSDSLVELGNRSLRPSWARIFYRSSERKLAKDINFMRTTSEDLIKARKADPNADQRKDLLAAMMNGVDPRTGSRMDDE
SIINNLLTFLIAGHETTSGTLSFAFYSMLKNPDAYLKAQQEVDSIMGRDPITVDKLFQLKYVPAVLRETLRQCSPIPGIT
LEAREDTLLDGKYHIRKGEAVAAIFSKSHLDPLVYGADAKEFKPERMMDENFDRLQQEFPNCWKPFGNGVRACIGRAFAW
QEMLLATSMLLQNFDFYLDDPLYKLKIAETLTIKPKDFLMGASLRHNMTPLDLESHLRGTNNKQGIPAAHSQSPPSTIKA
SIAATPISIYYGSNSGTCEILARRLASNASSHGFSVMVIDTLDTARNRLPQDHPVVIFVASYEGQPPDNAAHFVNWIQSM
TGNEVQKVHYVVFGVGNSEWRQTFHRIPKLIDDELGKRGGERLVTLGLTNVAEKDPFLDFEIWESKELWPALEKKYPDVT
GGTPEALVGSMGLSVDISVSRASALRKSVKEAIVTGVRDLAAPGLPRKRHIEMKLPSGCSYEVGDYLEVLPMNPRDAVTR
ALRRFKLPWDAVLTIAGSEITSLPIGIPVSAWDVLSSYVELAFLSTRKDTLVLASYAQSEKVRTEIELLASDVKFKSEIE
DKRVSILDLLERFPSVELPIATYLGMLQPIRTRQYSISSSPLKDPSHATLTYSVLETPSLSGQGLYMGVASNFLASLKPD
DRLQVSIRRSNIAFHLPLAPDTTPIICVAAGAGLAPFRGFIQQRSIQMKADRILAPALLIFGCRRRDDDLYREEFDAWEG
EGAVVVKRAYSRDAKLTAGCKYVQDRVIEQQEYIRKLWNQGGNVYVCGSRQVGDAVEGALGSILSGVQGGDREDGKRFLD
NFRNKRFVMDIFS*
>CYP505A17 Fusarium oxysporum
86% to CYP505A11
FOXG_17581 revised
MAGTVEIPSPSGLPLLGNITSIDPEFPLGSMVSLAEQH (1)
GEIYRLKFPGRSVVIVSTQALVNETCNEKRFKKCVNSALT (0)
EIRDGVHDGLFTARLGEENWGIAHRVLMPAFGPLSIQRMFDEMHDIASQLALKWARYGPNSPIMVTDDFTRLTLDTLAL
CSMGYRFNSYYSPVLHPFIEAMGEFLTEAGEKPRRLPLPGIVYRDRDRKYQQDIEIMRDTAREVLEARKADGSTRKDLLA
AMLEGVDTKTGKKMTDESIMDNLITFLIAGHETTSGLLSFAFYQLLTHPDAYQLAQNEVDRVVGKGPIQVEHLSKLPYLN
GVLRETLRLNATIPLFTVESFEDTLLGNKYPVKAGETIINLLAKSQLDPTVFGDNADKFRPERMFDENFARMNKEFPNSW
KPFGNGMRACIGRPFAWQESLLVMVMLLQNFNFVLDPNYHLGFKQTLTIKPKDMYMRAVLRDNLTPTTLERRLAGLPVLA
TGEANGTNGESADAEDGIPITILYGSNSGTCESLAQRVATDAAQHGFRVTKIDCLDMANGNLPADQPVVIITASYEGQPP
DNAGHFVAWVENAAQEEKPFKDVSYAVFGCGHKDWVLTFHRIPKLVDRSLAKHGATRLVDMGLADVSQNMVFSDFETWED
NILWPALEKRYKPGCKTMLTDKGLSVKSCTFRTLTLRQDVKEATVVCTKTLTSNIDVKSKKKHIEIQLPEGTGYTAGDYL
AVLPINPHEIVRRALRRFRLPMDAHLKISSSTPAALPTDTSVSAMDVLSSYVELSQPATKR
(0)
NLLIIAEAASDVETKAALTSLSQESYVEEISNKRVSVLEILERYPSVELSIGDFLQMLPSIRIRQY
(2)
SVSSSPLWNQAHATITFSVLKGPAFSGHGTYNGVATSYLDSLAEGDTLQVAIRSSPAAFSLPSNPECTPIICVAAGS
GLAPFRGFIQQRAIIYDSGRTLAPALLFFGCRAPDQDDLYRDEFDSWQRLGAVQVRRAYSRHREGCRYVQDRIWQDKEDF
IELWNKGAMVYVCGSRAMADSVKEVMLKVKTEIEKRSGGDIGLDEARKWFDEQRNVRYVMDVFD*
>CYP505A18 Aspergillus clavatus
87% to CYP505A13
Aspergillus fumigatus
ACLA_037140
MTESKTIPIPGPKGVPLLGNIYDIEQEVPLRSINMMADHYGEIYRLTTFGRSRVFLNTHELVNEACDEERFSKVVTAGLN
EIRNGIHDGLFTAHFPGEENWAIAHRVLVPAFGPLSIRGMYDDMYDIATQLVMKWARQGPHVPIMVTDDFTRLTLDTIAL
CAMGTRFNSFYHEEMHPFVEAMVGLLQGSGDRARRPALLNNLPTSENAKYWSDIEFLRKLAQELVDNRRQNPEDKKDLLN
SLILGRDPKSGQGLSDSSIIDNMITFLIAGHETTSGLLSFLFYYLLKNPRAYQKAQEEVDAVIGRRKITVEDLSKLPYIN
AVMRETLRLRSTAPLIALHAHPEKNKEDPVTLGNGKYVLNKDEAIVIVLDKLHRDPKVYGPDAEEFRPERMLDEEFDKLP
KNAWKPFGNGMRACIGRPFAWQEALLVVAILLQNFNFQMDDPSYDLHIKQTLTIKPKDFHMRAALRHGLDATQLGIMLSG
SVDSVPPESAGAASRSRKPQAAAPPSGQLKPMHIFFGSNTGTCETFARRLADDAVGYGFAAEVQSLDSAKENIPKEDPVV
FITASYEGQPPDNAAHFFEWLSGLKGKELEGINYAVFGCGHHDWHATFHRIPKAVNELVGERGGNRLCDLGLADAAHSDM
FTDFDSWGESAFWPAITSKFGGGKSETGTKATSNLQVEISSGMRASTLGLQLQEGFVIENQLLSQPGVPAKRMVKFKLPS
DMTYQCGDYLAVLPVNPSSVVRRAIRRFDLPWDAMLTIRKSSQASKGSTSIPLDTPVSAFDLLSTYVELSQPASKRDLNV
LADAAAADADVQAELRYLASSPSRFTEEIVKKRLSPLDILIRYPSIKLPVGDFLAMLPPMRVRQYSISSSPLADPSECCI
TFSVLNAPSLAAASLPPQEQEEAEQYLGVASTYLSELKPGDRAHISVRPSHSGFKPPMDLKTPMIMACAGSGLAPFRGFV
MDRAEKIRGRHSSIGSDKEIPETAKPAKAILYVGCRTKGKDDIHAAEFAEWAQLGAVEVRWAYSRPEDGSKGRHVQDLML
EDRAELVDLFDQGARIYVCGSTGVGNGVRQACKEMYLERRRQVRQEKRERGEDVAEDDEDAAAEQFLDNLKTKERYATDV
FT*
>CYP505A19 Aspergillus terreus
65% to CYP505A18
ATEG_01555.1
MSARIPIPTPKGIPILGNITELAQDVPEYSLYRLADQHGPIFRLTFLNQSIVFVNSYELANEEIRNCVHDGLFTANYPGE
ENREIAHRVLVPAFGPLMIRGMFDDMYDIASQLALKWARQGPNTAITVNEDFTRVSMDTIALCALGTRFNSFYRDEMPHF
IATMRNLLQASSARALRPADLVDARLQDPVDKKDLLNALILGRDPQTGQKLTTDSIVNNMITFLIAGHETTSGMLSFLFY
DLLKHPHAYRKAQDEVDRVIGRRKITVEDLTKLPYITAVMRETLRLHCPVTMLVVHAHPIRNNEDPVTLGNGRYELYKDE
PVAIHIGKIHRDPAVYGDDADEFKPERMLDGKFEKLPKNAWKPFGNGMRACIGRPFAWQEVLVVVAMLLQKINFQMVNPS
YDLRLKQAMTLKPDGFTFRAAIRHGLDATRLSAFLNRGSDLTEYAGALGRECNMEMVLGNHLKPMRIFFGSNMGTCEAFA
WRLAHDALQYGFRAEVKALDAARENLSRGDPVAFMTASYEGQPPDNATHFFEWLKGLEGDKLEGVNYAVSGCGHHDWQAT
FHSIPKAIDRLVHQRAGTRLCEIGTADAANSDMFTDFDSWGESVFWPAVMSKFGVQVNGTAKEASNLEIQIRPGRRVSAL
GLQLQEGQVLENRLLTAPSVPEKRMLRFKLPPDMTYQCGDYLAILPVNPPNVVRWAIRRFNLSWDSMLTVWKPTDASGLI
AVPLETPISALELFSTYVELSQPASKRDLKYLADAANGDTAVQNELRSLASDATRFVDEIVQKRVSPLDILLRHPVIDLP
LNTFLTMLLLMRPGEKAHMTVRRSTFGFKPPLDLQTPMIMACAGSGLAPFRGFIMDRAEKIRGRQLTGAPHPDIRGLAKA
ILYVGCRTKGVDDIHAEELAEWERLGAVDVRWVYSRPAGDSLSGSSPHEGSDGADRSRWRRHVQDQIVHDREELVALLER
GARIFVCGGTGVGQGVRQALKRIYLRQRWDGCRLRIDTDEGDPSRTADDEDAAAERFLEMLKTKERYATDVFT
>CYP505A20 Mycosphaerella fijiensis
55% to CYP505A9 Nectria haematococca
e_gw1.27.10.1
MAAIDERDTVPIPQPPGYPIIGNLLDVSGDVPIMNLADLGKKYGDIFSLSILGKRQIFVASAELMRELCDEKRFEKAINA
ALCQLRNGIHDGLFTAHGGEENWSIAHRTLVPAFGPLNIKDMFDSMKDIASQLVLKWARHGTTYKIPVAVDFTRLTLDTL
ALCAMDYRFNSFYTEHMHPFIDSMVNFLKYADVRSKRPGWMTSFYKADEAKWWSDIEYMRNLSAELIQQRRDQPNNSKDL
LNAMIKGKDPRTQKGLPESSIIDNMITFLIAGHETTSGMLSYAFYCLLKNPDTYRKAQEEVDRVIGKENIEAHHLDKLPY
ITAVLRETARLHSTAPSISLSPKSEQGEVIGGKYHISHGEVARVLLHNVHRDPAIYGEDAEEFRPERMLDDNFSRFTPYW
KPFGNGARGCIGRPFAWQEMMLVLPMLLQYFNFTLDDPSYVLHTAFTLTIKPKDLFIRATLREGWTPLSIERHLAGSTAA
DIKHGPNVPAATSESDDKGIPMTILYGSNSGTCEAFAQTLAAGARAHGFKASKVDTLDTAKQNLPAKEPVVIVTASYEGE
PTDNAAHFYNWLQNLSSDEKLKTSYTVFGCGHSDWKQTFHRVPKAIDSMLETAGGERMCEMGSADAARGDMMSAFQAWED
ETLWPALRQKFGGQEGDTSAASSLAQAVSIEVFSKRASNLRADVSEAKVLSTKTLTAAGARVKKHIELRLPSSLTYRAGD
YLAVLPLNPAETVHRVAKRFSLPWDAMLKITSRTGTTLPTDHPISAHNLFSAYLELSQPATKRNLAMLIEAAGDDQTKKE
LSDLATGDFQANITNKRISLLDLLERYPEIQLPLSAFVASLISMRVRQYSISSSPLSDPHVITLTYAVLDEPSLSGVGRH
VGVASHHLSQLQPGDMVHVAVKPSPAAFHLPSSADTTPVIMIAAGAGLAPFRGFIQERASQIGSGRKKLAPANLYFGCRH
PAQDDLYREEFDFWEKIGAVSVVRRSFSRAADLSEGHRHVDQVILADRRRLVELWDQGARVYVCGSRGLGESVKQAFLKI
AKDEAEAEGKEVSGEDLEKWFGLLRNERYSTDVFA*
>CYP505B1
AF155773 Gibberella moniliformis fumonisin biosynthetic gene cluster
also Fusarium verticillioides FVEG_00317
MSATALFTRRSVSTSNPELRPIPGPKPLPLLGNLFDFDFDNLTK
SLGELGKIHGPIYSITFGASTEIMVTSREIAQELCDETRFCKLPGGALDVMKAVVGDG
LFTAETSNPKWAIAHRIITPLFGAMRIRGMFDDMKDICEQMCLRWARFGPDEPLNVCD
NMTKLTLDTIALCTIDYRFNSFYRENGAAHPFAEAVVDVMTESFDQSNLPDFVNNYVR
FRAMAKFKRQAAELRRQTEELIAARRQNPVDRDDLLNAMLSAKDPKTGEGLSPESIVD
NLLTFLIAGHETTSSLLSFCFYYLLENPHVLRRVQQEVDTVVGSDTITVDHLSSMPYL
EAVLRETLRLRDPGPGFYVKPLKDEVVAGKYAVNKDQPLFIVFDSVHRDQSTYGADAD
EFRPERMLKDGFDKLPPCAWKPFGNGVRACVGRPFAMQQAILAVAMVLHKFDLVKDES
YTLKYHVTMTVRPVGFTMKVRLRQGQRATDLAMGLHRGHSQEASAAASPSRASLKRLS
SDVNGDDTDHKSQIAVLYASNSGSCEALAYRLAAEATERGFGIRAVDVVNNAIDRIPV
GSPVILITASYNGEPADDAQEFVPWLKSLESGRLNGVKFAVFGNGHRDWANTLFAVPR
LIDSELARCGAERVSLMGVSDTCDSSDPFSDFERWIDEKLFPELETPHGPGGVKNGDR
AVPRQELQVSLGQPPRITMRKGYVRAIVTEARSLSSPGVPEKRHLELLLPKDFNYKAG
DHVYILPRNSPRDVVRALSYFGLGEDTLITIRNTARKLSLGLPLDTPITATDLLGAYV
ELGRTASLKNLWTLVDAAGHGSRAALLSLTEPERFRAEVQDRHVSILDLLERFPDIDL
SLSCFLPMLAQIRPRAYSFSSAPDWKPGHATLTYTVVDFATPATQGINGSSKSKAVGD
GTAVVQRQGLASSYLSSLGPGTSLYVSLHRASPYFCLQKSTSLPVIMVGAGTGLAPFR
AFLQERRMAAEGAKQRFGPALLFFGCRGPRLDSLYSVELEAYETIGLVQVRRAYSRDP
SAQDAQGCKYVTDRLGKCRDEVARLWMDGAQVLVCGGKKMANDVLEVLGPMLLEIDQK
RGETTAKTVVEWRARLDKSRYVEEVYV
>CYP505B2 Aspergillus niger
fgenesh1_pg.C_scaffold_1000650|Aspni1
62% to CYP505B1
MSDAKIIPIPGPRPLPLLGNILDFDLDNLTQSLDRLSKAHGPIYALTFGSSTEIMVTSRRIAEELCDETRFCKLVAGGLE
KMKPVVGDGLFTAQSDDPKWAIAHRILMPLFGTMKIREMFNDMKDICEQMCLKWARLGESFPLDVCKNFTTLTLDTISLC
TIDYRFNSFYRDGKEDPFVEAVIAVMTDAFTQSNLPDFVNNWFRHKAMADFHDHAQNLRRRTEEIIQERRRSPVERNDLL
NAMLTAVDPKTGERLSDQSVVDNLLTFLIAGHETTSSLLSFCFYYLLENPDVLQKARDEVDQVIGDGPMMVEHLQKLPYI
ESILRETLRLRDPGPGFYLKPLKDDILDGKYYVKKDQPIFIVFDSVHRDPETYGSDANNFRPSRMSQENFEKLPPCAWKP
FGNGVRSCIGRPFAWQQSLLAVAMILQNFDLIKDETYKLKYHVTMTVRPVGFHMKVRLRRQRRATDFAQKLHAPVASQVP
LINHHQSIRPNTVEGSRITILHGSNAGSCEALALRLAADAGEYGFTRSKIEPLGSAVGKLPTDNPVIIITASYNGEPADE
ASDFVAWLKTAGRDELSGVSFSVFGCGHRDWASTYFAVPKLLDAEMERAGGRRIAPLGTADSATSDLFTDLEKWSVTHLF
PGLGNTEHIRRDAQGVKVSSSCQVMLSDPPRVTLRKGFVPTSITESRCLSQPGVPEKRHLELRLPDGFTYQPGDHLYRVL
SRFHLEGDMLLTLTRSQSLGLPVNTPISASDLFGAYVELRQIASPKGILALADSTPDSCTQTILRDLAGDLFKVEIQDKY
VSVLDLLERFPTINPSIGLFLSLLTPMRPRAYSFSSSPNEKPGYGTLTYTVVGSARSTGNRIELLSLFTPSCDPLHSTTP
LYSGLSPLVMVAAGTGLAPFRGFIQERRFRQLAGKKVGPALLFYGCRGRDLDDMYRDEMDGYEKEGVVSIHRAYSRVKGA
DFRYIDSAIARFLDHVVSLWASGGVVRVCGGKKMSNSVFEVLGPALLERDRLDGKTDVTDVAEWKRDLPRGRYVEEIFL*
>CYP505C1 Magnaporthe grisea MG07953.4 42% to 505A1
AACU01000977 cont2.1474
MSSMTATETTAKASQTEQQSKCPVLGPSGPGCPYSKGEKIPGPTAYPLIG
SIPHLDLKAPFESMLAIQKQYGPIFQMVFAGKREISVCTRELAHEVCDET
RWHKLVTSGVSTLRQVVQDALFTAHHGSRQWGISHRILKPIFGPLSVRSM
FDEMSDVAEQLCLKWARHGPDHAIDVAGDYTRLTLDTIALCMMDYRFNSF
YRDGQHHPFVKHMVAILSEADIQAMLPDWAGVFRPRAMRKFKKDIQLMTD
LCRGMVEARRANPVKRRDFLNAMLQNSDPETGEKLDDEEIVRNLITFLVA
GHETTSGMLCFATYYLLKHPETLAKAQKEVDDVVGTGPVTATHLGQLPYL
DGVFREALRLMPTAVAFYVTPYKPEMLGGKYLVEPGEAVCLLLDPIHRDR
AVYGPDADEWKPERMLQEKFEALPADAWKPFGNGQRICLGMPFTWQESKL
AMAMLLQNFDLSMDDPDYKLKIKHLLTIKPEGFNIRAKLR
>CYP505C2 Fusarium graminearum FG07596.1
AACM01000315 FGcontig1.315_scaffold4
MAIKDGGKKSGQIPGPKGLPVLGNLFDLDLSDSLTSLINIGQKYAPIFSL
ELGGHREVMICSRDLLDELCDETRFHKIVTGGVDKLRPLAGDGLFTAQHG
NHDWGIAHRILMPLFGPLKIREMFDDMQDVSEQLCLKWARLGPSATIDVA
NDFTRLTLDTIALCTMGYRFNSFYSNDKMHPFVDSMVAALIDADKQSMFP
DFIGACRVKALSAFRKHAAIMKGTCNELIQERRKNPIEGTDLLTAMMEGK
DPKTGEGMSDDLIVQNLITFLIAGHETTSGLLSFAFYYLLENPHTLEKAR
AEVDEVVGDQALNVDHLTKMPYVNMILRETLRLMPTAPGFFVTPHKDEII
GGKYAVPANESLFCFLHLIHRDPKVWGADAEEFRPERMADEFFEALPKNA
WKPFGNGMRGCIGREFAWQEAKLITVMILQNFELSKADPSYKLKIKQSLT
IKPDGFNMHAKLRNDRKVSGL
>CYP505C3 Aspergillus oryzae
GenEMBL
BAE63564.1
54% to
505C2, 50% to 505A8, 45% to 505A3, 47% to 505B1
revised
3/18/2009
MRQNDNEKQICPIPGPQ
GLPFLGNILDIDLDNGTMSTLKIAKTY
YPIFKFTFAGETSIVINSVALLSELC
DETRFHKHVSFGLELLRSGTHDGLFTAYDHEKNWELAHRLLVPAFGPLRIREMFPQMHDIAQQLCLKW
QRYGPRRPLNLVDDFTRTTLDTIALCAMGYRFNSFYSEGDFHPFIKSMVRFLKEAETQATLPSFISNLRVRA
KRRTQLDIDLMRTVCREIVTERRQTNLDHKNDLLDTMLTSRDSLSGDALSDESIIDNILTFLVAGHETTS
GLLSFAVYYLLTTPDAMAKAAHEVDDVVGDQELTIEHLSMLKYLNAILRETLRLMPTAPGFSVTPYKPEI
IGGKYEVKPGDSLDVFLAAVHRDPAVYGSDADEFRPERMSDEHFQKLPANSWKPFGNGKRSCIGRAFAWQ
EALMILALILQSFSLNLVDRGYTLKLKESLTIKPDNLWAYATPRPGRNVLHTRLALQTNSTHPEGLMSLK
HETVESQPATILYGSNSGTCEALAHRLAIEMSSKGRFVCKVQPMDAIEHRRLPRGQPVIIITGSYDGRPP
ENARHFVKWLQSLKGNDLEGIQYAVFGCG (1)
HHDWSTTFYKIPTLIDTIMAEHGGARLAPRGSADTAED
DPFAELESWSERSVWPGLEAAFDLVRHNSSDGTGKSTRITIRSPYTLRAAHETAVVHQVRVLTSAETTKK
VHVELALPDTINYRPGDHLAILPLNSRQSVQRVLSLFQIGSDTILYMTSSSATSLPTDTPISAHDLLSGY
VELNQVATPTSLRSLAAKATDEKTAEYLEALATDRYTTEVRGNHLSLLDILESYSVPSIEIQHYIQMLPL
LRPRQYTISSSPRLNRGQASLTVSVMERADVGGPRNCAGVASNYLASCTPGSILRVSLRQANPDFRLPDE
SCSHPIIMVAAGSGIAPFRAFVQERSVRQKEGIILPPAFLFFGCRRADLDDLYREELDAFEEQGVVTLFR
AFSRAQSESHGCKYVQDLLWMERVRVKTLWGQDAKVFVCGS
VRMNEGVKAIISKIVSPTPTEELARRYIAETFI
>CYP505C3 Aspergillus flavus
99% to CYP505C3 Aspergillus oryzae
AFL2G_10943
MRQNDNEKQICPIPGPQ (1)
GLPFLGNILDIDLDNGTMSTLKIAKTY ()
YPIFKFTFAGETSIVINSVALLSELCDETRFHKHVSFGLELLRSGTHDGLFTAYDHEKNWELAHRLLVPAFGPLRIREMFPQMHDIAQQLCLKW
(2)
QRYGPRRPLNLVDDFTRTTLDTIALCAMGYRFNSFYSEGDFHPFIKSMVRFLKEAE
TQATLPSFISNLRVRAKRRTQLDIDLMRTVCREIVTERRQTNLDHKNDLLDTMLTSRDSLSGDALSDESIIDNILTFLVA
GHETTSGLLSFAVYYLLTTPDAMAKAAHEVDDVVGDQELTIEHLSMLKYLNAILRETLRLMPTAPGFSVTPYKPEIIGGK
YEVKPGDSLDVFLAAVHRDPAVYGSDADEFRPERMFDEHFQKLPANSWKPFGNGKRSCIGRAFAWQEALMILALILQSFS
LDLVDRGYTLKLKESLTIKPDNLWAYATPRPGRNVLHARLALQTNSTHPEGLMSLKHETVESQPATILYGSNSGTCEALA
HRLAIEMSSKGRFVCKVQPMDAIEHRRLPRGQPVIIVTGSYDGRPPENARHFVKWLQSLEGNDLEGIQYAVFGCG
HHDWSTTFYKIPTLIDTTMAEHGGARLAPRGSADTAEDDPFAELESWSERSVWPGLEAAFNLARHNSSDGTGKSTRITIRSPYTL
RAAHETAVVHQVRVLTSAETTKKVHVELALPDTMNYRPGDHLAILPLNSRQSVQRVLSLFQIGSDTILYITSSSATSLPT
DTPISAHDLLSGYVELNQVATPTSLRSLAAKATDEKTAEYLEALATDRYTTEVRGNHLSLLDILESYSVPSIEIQHYIQM
LPLLRPRQYTISSSPRLNRGQASLTVSVMERADVGGPRNCAGVASNYLASCTPGSILRVSLRQANPDFRLPDESCSHPII
MVAAGSGIAPFRAFVQERSVRQKEGIILPPAFLFFGCRRADLDDLYREELDAFEEQGVVTLFRAFSRAQSESHGCKYVQD
LLWMERVRVKTLWGQDAKVFVCGSVRMNEGVKAIISKIVSPTPTEELARRYIAETFI*
>CYP505C4 Aspergillus flavus
46% to CYP505C3
AFL2G_00477
Note: this seq has no ortholog in A. oryzae
MSGREDHEIPGPKPWPILGNGLDFPSEGYTDTLIELGLKYYPIYKLTFAGSVEVMVNSVALTNELCDESRFSKVVGPTLE
ELRSAAGSGLFTAYNGEPEWETGHRLLAPVFGPTKIRKMFDHMYEMVEQLSLKWERYGSTYPIEVADDFSRVTLDTIALC
GMSFRFNSFYRDGTFHPFVDSMNRWLKNSDTMGSTPRILKSFLFRAQRQYKYDIHLMRQTCLDLIERRKKDQSEHEDLLD
SLLKGVDPTTGARLSEETCVDNLITFLIAGHETTAGLLGFVFYYLAKYPHVQRKAQEEVDRVYGDGSITVNDLQKLRYIT
AILREALRLNPTAPSWGVSPHRDEIIGGKWHVKKGQPLNIMLHSVHRDREVYGPTADEFDPERMLDEAFERLPPNAWKPF
GNGKRGCIGRAFAWQEALLITSYLLHKFYFTLHDPNYTLVLQEALTVKPKGCRILAQPRGKKPTASSATTNDSLRGASGR
VSSPSVPRSSGPPLLVLYGSNAGTCEALGRQLARDIESRSSYTCTLAELDSYVGKLPRDQPVLILTGSYDGAPPSNAVKF
VKWLERPIVESLKGVSYAVFGCGHKDWRATLYKVPAAIDELLAQKGAHSLAPLFKVDTGSDDAFVQLDMWIERDLTGALD
MANTASGGTDSLRVFLQDPPNHRAGYVETVVCDVKLLTTPTTAKKIQVDLMVPTGLAYSVGDSISILPLNPKHTIQRALS
RFHLAWDTYLKLENDNLTHLPTEYPISVADLLGSFVELGQTATLGNMKTLIDATDDWTTKQALLSLRDAHEDHIADKHVS
VLDLLEQFPTIPISIEGYLSMLPLLRPRIYSIASDPQWQPGLLSIIASVIDEPHWRSDEDDLYRSELDGFEREGIVEVKR
AYSREVHSSDTRGGRYVQDRLELEKEDVIELWKLGARVYVCGGDGMARGVRAVLTRILEETGEGGDELLVAPRYVTEIFS*
>CYP505D1 ug.73.17.1 Phanerochaete chrysosporium
MTHEIPCPPAWPFLGHMTSIDPEYPTLSLHLFTKQYGEIYRLRLPGRDLVVVNSQELVHEVSDDKRFKKSPKGGLQELRPLIGDSLLTADYPREENWGIAHRVISPSFNPIGLRGFFDDMVDVISQLVLKWERFGPHYKIDIAEDFTAATFEVIALCCASYRMNTFYTGGTHPVATAVVDYGVEGFARGKRGRLLSWLMRSATAKFEQDKETLLQYADELLEERKAHPTDRKDVLWAMMNRADPVTGKKMTDLSVKQNLLTLLTAGHETTSAFMSIIIYYLIKYPEAMRKLREEIDTVLGDRQMTADDLARLPYLLAVMRETLRLTPVAPGRVIEAIEATTLKGGQYAIDKGQDILVAVHSSHRDPKVWGDDVDDFRPERMLDGKFEALPPDSWQPFSAGLRACIGRAIAWQEAQIMITFLVQHFTFTLADPQYELRIKQAFTLRVHDLYVHARRRTDRRGCVTLLPPAPAPGVGLAEAKGAPHDGGEGALPMHVFYGSNMGTCEAFAQRIVADAGRHGFKASLAALDAAVANLPTDGPVVIVTASYEGQPPDNAAHFVEWATNMRGSGAPALAGVVYALFGCGNRDWVQTYQRVPTLVDGALAAAGAERLLPRAEGDAGSGGFFEAFARWEGALWAALETRYATMKSGSAEGAVDVEVLDAGVSRADVLRQPDTMMGTVLENRVLTAQGAPVKRHIEFKLPEQVTYKAGDYLTVLPMNPPRDVRRAMARFGLLPDQEVTIRTKTPSSLPTGRPISVYTLLSAYVELSQPATTRDLRFLSEAAKSEAEKLVFKELAENYTECVLTGRLSVLDILEAHPNVDVPFGAFLQLLPSMRARQYSISSSPLCDPTRASLTIRVFEAPTSPGRKDPLLGVASTYLGGLHPGDRVQLAVRPCKTAFRLPADPAVPLVLVCAGAGLAPMRGFLQERALQKEGGRDVGKSLLFFGCRHPEEDYLYRDEDLKKWVELGIVDVRVAFSRAQDQSLGCKHVQDRLWHDRTDVMDACDKGAKLYLCGSAKMAAGVKDKLVLVVQDAMQLEHAAAVEQFNTMMAGRFATDVFE
>CYP505D2 pc.73.4.1 Phanerochaete chrysosporium
MTEPIPTPPSVPFLGHIPLLDREVPMLSLALLAEQYGDIYRLIFPGRSSIAIASQELVHEVSDDKRFRKTVQGPLGEVRAVAGDGLFTADVPGEENWDIAHRILMPAFSFMKIRDMFDDMVDVVAQMVVKWERFGPRFRIDPAVDFTALTLEAISLTTMSYRMNAFYTFVQNGIHPFAKAMNEFLQESGGRSRRGRVLSAFMRGATAKWEQNRDLMMKYVDDNARSSARKDVLDLMMNEKDPVTGRKMTELSIKQNLLTFLIAGHETTSGMLTFTIYYLLKYPAVMRKLREEIDTMIGDRPMTVDDVNKMPYLTAVMRESLRLGPSVPGRMIESLKDQTLKNGKYAVAKGEILVVCNFIAQRDSKVFGDDADEFKPERMMDGKFEALPPDAWQPFGAGVRGCIGRAFAWQEVQIVLVYLLQHFNLAFADPNYDLRLKQTLTLKPNEFYIHAIPRAERRRAIPLLGPRAGPTSAPVNGTNGIADEGGHPMYVYYGSNMGTCEAFAQRIAGDAGRYGFSAAVASLDSATENLPTDGPAVVITASYEGQPPDNAAHFVEWLGALGDADSPLAGVAYAVFGCGNHDWVQTYQRVPTRVDEGLAAAGAERLLPRGEGDAGAGDFFEAFTRWEAALWEALGKKYETAKGSGKEAGVQIKVTNATVSRADALRQADTMMGTVIENRVLTAPGAPEKRHLDIRLPEGTTYNAGDYLAILPTNPSRDVRRALARFGLLPDQEITIESASPTSLPTGRPISAHTLLSGYVELAQPATTRDLRLLSEAATSDAEKLVFQKLADNYAEEVLAARLSVLDILEAHPDVNIPLGAFLQLLPTMRVRQYSISSSPLADPTQASLTIRVFEAPCTAGRKAPLLGVASTYLGGLHAGDRVALAVRPCKTAFRLPADPALPLVMVCAGAGLAPMRGFLQERAAQKRAGRDVAKSLLFFGCRDPAEDYLYRDGDLAEWTALGIVDVRAAFSRARDQSLGCKYVQDRLWHDRADVMAAWDKGAKLYLCGSAKMAAGVKDKLVLVVQDAMQLEHAAAVEKFNMMMAGRFATDVFE
>CYP505D3 ug.73.15.1 Phanerochaete chrysosporium
MSQPIPMPPSVPFLGHVTTIDAELPVMSFRLLAKQYGEIYELNMLGRCILWMLVINTQELLHEVSDEKRFRKIVSGGLNEVRNAAGDGLFTAHADKEQNWAIAHRILMPSFSAMNMRNMFDDMVDVVSQLVLKWERFGPYHKINPADDFTALTLEAISFCAMSYRWVIFYSIYVRNDVHPFARAMSDFLLESGARARRPGIIAPFMRSANAKYQQDIDVLMNFVDEIIADRRAHPTDKKDILNVMLHAKDKETGLGMTEDNIRRNLLTFLIAGHETTSGMLTFIMYYLLKHPEAMRKLREEVDTVIGERPMTVDDVNKLPYLIAVMREALRLGPPASARGASPYEDTTIGGGRFAVPKDTFIMCSLYNIHRDTKVWGEDAEEFRPERMLDGKFEAMPPDSWQPFGYGMRGCIGRPFAWQEAQIALVYLMQRFTFAMADPGYDLRLKQTLTIKPHEFFIHAIPRADRAHGAPLFSTPSPLRPRAASSAQPPADTAGRTPVYVLYGSNTGTSEGFAQRIASAAAGKGMYSRSTIGTLDSAAAHLPTDGPVVIVTASYEGQPADNAAHFVEWLSSLQGTELEGVRHAVFGCGNRDWQATYQRVPTLVDDALTARGSIPLVLRGAGDAAASDFFEAFEKWETGLWGALREAYGVATGANAESGISIETLDTGKGRASILRQPDAALGTVVENRVLTAPGAPEKRHIEFKLPEGMTYQTGDYLAILPVNPQRDVHRALARFGLLPDQEITIRSAGPTTLPTDRPVNVSTLLSGYVELGQPATTRDLRLLSEHAKSDSTKAALQALLDNYASDVLGARLSVLDILEAHADIALPFAAFLDTLPSMRVRQYSISSSPLADAAHASLTISVLAAPARSGRPERFLGVASTFLGGLRAGDRVPLAVRPSAAAFHPPADPSVPLLLVGAGAGLAPLRGFLQERALQKKAGRDVAKSILFFGCRRPDEDLLYGDAELKEWQELGVVDVRPAFSRAPEHSFGCKYVQDRVWHDRAEAVATFKAGAKLYICGSSRMAAGVKEQIVLIVQEDSKLEYPEAVEKFEKIMVGRFATDVFE
>CYP505D4 pc.73.11.1 (ug.73.16.1) Phanerochaete chrysosporium
MTHPIPTPPTVPLLGHATLIDHDFPMGTNALWAREYGEIFRMCFPGRTVYVVSSYELVHEASNDKLFRKSVGGPLAELRSSVGDGLVTANVPGEENWGIAHRVLMPCFSTISLRNMFDDMVDVVSQLVLKWERFGPHYRIDPAEDFTALTFEAISLCSMSYRMNPFYNSAMHPFAAAVVDFQVECMARSRRGKLLNALIRSAKTKFEQDRDLLMQYADETVLEDRKAHPIEKKDVLWTMINRADPVTGKKMTDLSVKQNLLTLLMAGHETTSGMLTFAMYHLLKNPEAMRKLREEVDTIIGDRAMTADDLSRLPYLVAVMRETLRLSPSAPARIVQAMEATTLGGGKYAIAKDDTLLIATYVSQRDPAIWGPDAEEFRPERMLDGKFEALPPDAWQPFGAGIRSCIGRPFAWQEVQIVLVSLMQRFTFAFADGHYDLRMKQTLTMKPHDFYIHAIPRTDRARVPPLLGVRAAPAQSTDGEKGKVEAGEGAPPMYVYFGSNMGTAESFAQRIAGDAGRHGFKATVAPLDAAVEKLASDGPVVVITASYEGKPPDNAGHFVEWLSNLGDESALAGVSFAVFGCGNRDWARTFQRIPTLVDDALGAHGGARIIPRGVGDASTGSFFESFANWEEGLWAALAEKYETAKPTSVGGLELVVTDAGPGRADALRQPDTTMGTVVENRVLTAPGAPVKRHIEIQLPEGTSYTAGDYLAVLPTNPPRDVRRVLKRFALLADQEITIQSADPTSLPTGRPVNVYALLSGYVELAQPATTRDLRLLIEASSTDAEKQVFKELADNHAERVLKPRLSVLDIVEAHPSVHVPFAAFLQLLPAMRVRQYSISSSPLVDPARATLTIRVFELPGAPARRPHLGVGSTFLARLAPGDRVQLAVRPCKPAFRLPADPTVPLVLCCAGAGLAPMRGFLQERAMQKQAGRDVGKSLLFFGCRDPQEDYLYKDDDLKAWVDLGIVDVRVAFSRAPDQSLGCKYVQDRIWHDRADVLAAWNQGAKLYLCGSAKMATGVKDKLVHVVRDATGVDEASASDKFNEMMDRFRYRYFRVRYEHVVSAAFTYCIWNYLRDHSTRFNCPIAMACTFRLGAIARGSICATWLRWREE
>CYP505D5 pc.73.14.1 Phanerochaete chrysosporium
MTTPIPSPPSIPFLGHVTIIDREVAIYSYNLLAKQYGEIYQLNMMGALRIIVICSQELLHEVSDEKRFRKIPRSALEQVRNAVGDGLFTANGDDPNWHLAHRILMPAFSTMNTRNMFDDMVDVVNQLVQKWERFGPRHKIDPAQDFTALTFEAITFCAMSYRELTLPQEGVHPFARAMADFLVESGNRALRPGIVQPFMRSTNSKYEEDIKIMEHYVNDIYEQRKANPTDKKDILNLMMYGKDTQTGEGLSEKTIKDNLLTFLIAGHETTSGMLTFIIYYLLKNPEAMRKLREEVDTIIGSRPMTVDDVHKLPYLIAVMREALRLGPPAPMRGAASFEDTLLKGKYPVAKDVPIYCGVYMVHRDPKVWGEDAEEFRPERMLDGRFEALPPEAWQPFGFGVRACIGRPFAWQEAQITVVYLMQRFTFVMHDPSYDLQLKQTLTIKPHEFFIHAIPRTDRPSIVPIPTPSSTLLRDQTAPAAQPPVTTPGEGGGHRMYVLYGSNTGTCEAFAQRVASDATVHGEVSVFIGTLDSAAGHLPSDGPVVVVTASFEGQPADNAAHFVSWLTALNGSALADVSFAVFGCGNRDWASTYQRIPTLCDDTMAARGGKRLVPRGEGDAGSSDLFESFEHWEAGLWEALQKTYGTTKVEGRQEAIKVSTVDAGTARATALRQPDTMLGTVVENRLLTSPGVAEKHHIEFQLPDGLTYRTGDYLAILPMNPSRDVQRVLAHFSLLPDQEVTISAAGPSPLPTGRPVNVSSLLSGYVELSQAATTRDLRILMSAAKSEDTKAALSELLDGYAEKMQAARLSVLDILEAHPGLDISFALFLQLLPSMRVRQYSISSSPLADPTRASLTVSVLSAAPTAGRREPFLGVASTYLASLRAGDCVQLAVRPSAAAFHPPADPAVPLVLFCAGAGLAPMRGFLQERALQKQAGRDVAKSILFFGCRSPQHDFLYADSDLRTWTELGVVDVRPAFSRDTEHSAGCKYVQDRVWADREDVVKVWKAGAKMYVCGSGRMATAVKQKLVEIIAAQLNVDSEKATETFNNIIKGRFATDVFE
>CYP505D6 pc.17.40.1 Phanerochaete chrysosporium
MTSTIPTPPSIPFLGHVASIEREVPLRSFRLLSEQYGEIYELNILGRKLLVVSSAKLMSDVSDDKKFYKNMSGPLMQVRNAVGDGLFTAYGEEPNWGIAHRLLMPAFGTASIRDMFPDMLDLASQLVLKWERFGPKHRIDPAEDFTRLTLDTIALCAMSYRLNSFYRDSSHPFVQSMVDFLVECNLRANRPGLLTSVMVQTNAKYEEDIKTMTELADEIIAERRRNPTDKKDLLNIMLYSKDPKTGQSLSDVNIRNNLLTFLIAGHETTSGLLTFALYYLIKNPEAMRKAHEEVDEVLGDQQIQLTDIGKLKYIDAVLRETMRLSPTAPMRTVRPFEDITIGDGKYFVPKDYTVVINTIVAQRDPTVWGEDSNEFHPERMLDGKFEALPPNAWQPFGFGMRACIGRPFAWQEAIIALAVLLQKFDFVLDDPSYELELKQSLTIKPAHFYVHALPREGKPQLLATPSAAPFSSHARETTNASLPASPGTEAKQPMYVLYGSNTGTSESFAQRIANGAAAHGFRATLGTLDSVADHLPTDGPIVIVCASFEGEPADNAAHFVERLTSLQDKPLQNLRFAVFGCGHHDWFRTYQRIPKLIDQTLEDRGAQRLVPRGEGDAGSSEFFEAFEAWETKLWEVLPEEYNTVVKQDITSGLKVETVGEGATRAVDLRQHDAALGTVIENRVLTAPGAPQKRHIEFELPEGVTSRAGDYLAILPSNPPQDVHRVLARFGMLPEQQIVISSSGPSSLPTGRQISAFDLLSGYVELSQPATARDVRTLLNIDSSDATKESLKALLESYSDAVLGRRLSVLDLLEQYPDIKLPFAAYLALLPSMRIRQYSISSSPLWNAQRVTLTVSVLEAPALSGRKEPFLGVASTYLANLRPGDKVQMAVRASNAAFHLPQDPRTPLVLFAAGSGLAPMRGFLQERALQKKAGREVGRAVLFFGCRRPDEDYLYSDSDLKEWEELGVVELRPAFSRAPEKSEGCKYVQDRVWHDRRALDGLYEAGAKWFVCGSGKVARGVKEVLTAMIKESRGYSDEEAAAAFERATVGRFATDIFE
>CYP505D7 gx.187.5.1 Phanerochaete chrysosporium
ATPIPSPPSVPFLGHVTIIDREVAIYSYNLLAKQYGEIYQLNMMGAKVVVICSQELLHEVSDEKRFRKVPSSALDQVGNAAGEGLFTAHGDNPNWHLAHRILMPAFSTMNTRNMFDDMVDVVNQLVQKWERFGPRYKIDPSQDFTALTLEAITFCAMSYRYGRIXVHPFARAMADFLVESGNRALRPGIVQPLMRATNSKYEENIKIMQKYVDDVYNQRKENPTDKKDILNLMMYGKDPKTGERLSEKTIKENLLTFLIAGHETTSGMLTFILYYLLKNPEAMRKLREEVDTMIGSRTMTVDDVHKLPYLIAVMRETLRLGPPAPARGTAPFEDTLLKGKYPVAKDGRIYCGIYMVHRDPKVWGEDAEEFRPERMLDGRFEALPPEAWQPFGFGVRACIGRPFAWQEAQITVVYLMQRFTFVMHDPSYDLQLKQTLTIKPHEFFIHAIPRTDRPSIVPIPTPSSTLLRDQTAPTAQPGPVTTPGEGGGHRMYVLYGSNTGTCEAFAQRVASDATVHGFKAVIGTLDSAAGHLPSDGPVVVVTASFEGQPADNAAHFVSWLTALNGSALADVSFAVFGCGNRDWASTYQRIPTLCDDTMAARGGKRLVHRGEGDAGSSDLFESFE
>CYP505E1 Aspergillus niger
fgenesh1_pg.C_scaffold_3000014|Aspni1
77% to CYP505E2, 48% to CYP505C3
revised 3/23/2009
MRDAERIPGPT (1)
PLPVVGNLFDIDLEHVLQSVIGLANKY (1)
GPLFQITINGEKQIFATSQALVDELCDESRFHKAVASGLEN
LRMLAHDGLFTAYHGERGWGIAHRILVPAFGPLRIQSMFDDMGDLAQQLCLKW
ARQGASNSINITDDFTRLTLDTIALCTMDFRLNSFYNNDTMHPFVESMLYVLREADVQSALPGIANSVRIMAHRRMLKNIEA
MRTIARDIIHDRRKKENPADDLLNTLLNGRDPVTGEGMSDESIIDNVITFLVAGHETTSGLLSFTFYYLVQHPDILKKAQ
KEVDETVGQAQISVQHLAELPYIDAILKESLRMMPTAPGFTVTPKKAETLGGKWLLNAGQPINVLLPACLRDRSIFGPNA
DEFSPERMLAENFSKLPPNSWKPFGNGERSCIGRAFAWQEAQLVVAMILQNFDLVPDDPSYTLRIKETLTIKPDGFRVRA
TLRHRQTATGLFQHTLSARNDTSLASSSAHFIKKSEDQAPAGGRPICFFYGSNSGTCKALAHRLASDLMPYGFTDQKLAV
LDTAVDNLPRDQPVIILTTTYDGQPTDDAKKFVAWLESGKVPALQGISYAVFGCGHHDWTQTFYRIPTLIDELMHKAGAT
RLAPRGTANAAVSDLFSDLEAWEETSLLPALRETFLLSSSSDLEPRNLHQLQISLSKPRRIDLHKDLMEARVTTVRILTN
PDTPEKRHIEFRFQGDTTLRPGDHVNVLPVNPPSTVLRVLAQFNLAPDYSITINSFNTLGLPQATPVSASELFSAYVELS
QPATRN (0)
NLRILAATAQSDEDKQELIHLQ
DSYDSLVRDKRVSVLDLLEQFPSVSLPIAAFISMLPALRLRTYSLSLAPSFKPSHGSLTFSVVNEPARNGNRRY
LGVGSNYLASLTPGSILYLSPRPAKEAFHLPVDQSRIPIIMICAGSGLAPFLSFIQDRMIWQQQDKPLARALLFFGCGGR
FLDDLYHEELSEFEAAGVVDVRRAYSKVLDYDMARGCKYVQDRLVAEANAIRHLWAQDATIYVCGSADMAKGVEGVLEKL
LGMLPRERYVTEIYQMQTRDNVSEWLI*
>CYP505E2 Neosartorya fischeri
~77% to CYP505E1
NFIA_004540
Note: this seq does not have an ortholog in A.
fumigatus
one stop codon
MKDTERIPGPK (1)
PLPVVGNLFDIDFEHGLESIIEMANNF (1)
GPLFQITINGEKQIFATSQALVDELCDESRFHKAVVAGVQNLRMLVNDGLFTAYHGERGWGIAHRILVPAFGPLR
IRNMFEDMSDIAQQLCFKW ARQGGSTSINITDDFTRLTLDTIALCSMGFRLNSFYNSETMHPFVQYMVDVLREADVQAML
PGIANSLRVTAQRRMSKNIEAMRSIAREIIQGRRDKGESVDDLLNTLLSGRDPVTGEGMTDDSIIDNVITFLIAGHETTS
GLLSFTFYYLLQNPHILEQARNEVDDVVGVD*ITVQHLAK
LPYIDAILKETLRLMPTAPAFAVFPKKPEVLGGKWTINARQAVIVLLPACLRDQAVF
GPDAGEFRPERMLEENFSQLPPNSWKPFGNGERSCIGRAFAWQEAQLVVAMILQTFDLVGNDPSYKLRIKETLTIKPDGF
RLRATLRRGQSATGLSRRSMSVSADGTSAASSTHLAGKCKGLEPAGGQPVSFFYGSNSGTCKALAHRLASNMMARGFTNQ
KLAPLDSAVDNLPRDQPVIIVTTTYDGQPTDDAKKFIAWLESGKVPALQGVSYAVFGCGHQDWTKTFYRVPILIDDMMHK
AGATRLAARGAANAAVSDLFSDLEKCEETSLLPALRETFLPSSSSDVELLNPQQLQISLSKPRRVGMHQGLVEVKVTAVR
ILTSPGTLEKQHVEFRIQGETTLRPGDHLNILPANPPSTVSRVLAHFDLAPDYSITINSFNTLGLPHATPVLAAELFSSY
VELSQPATRNNLKALAATALSNADKQELIRFHDSNDPLVRDKRVSVSDLLEQFPSISLPLAAFISMLPALRVRTYSLSMA
PSFKPSHGSLTFSVVNEPAWSGNGQYLGVGSNYLASLTLGSILYISPRPAKDAFHLPMDQSSEPIIMICAGTGLAPVLSF
IQERMVWLQQGKPLAKALLFFGCRGPHLDDLYHEELSEFESAGVVEVRRAYSKAPDHDLAKGSRYVQHRLVTEAEAIQDL
WAQNAKVYVCGSGNLAKGVQTALENMLGALPQE*
>CYP505E3 Aspergillus terreus NIH2624
AAJN01000001.1
79% to CYP505E2
ATEG_00065.1
MIKETEQIPGPR (1)
PLPVVGNLFDMDLEHGLECLIRLADDF (1)
204332
GPLFQITINGEKQIFATSQALVDELCDESRFHKAVMGGLEKLRMLASDGLFTAYHGER 204505
204506
GWGIAHRILVPAFGPLRIRNMFEEMNDVAQQLCLKW ()
ARQGSSTSINITDDFTRLTLDTIALCTMNFRLNSFYNNETMHPFVKSMLYVLRESDI 204865
204866
QSMLPGIANCIRVKARSRMSKHIQLMRNMARGIIQERRDQAEPVDDLLNTLLNGRDPVTG 205045
205046
EGMSDDLIINNVITFLIAGHETTSGLLSFTFYYLLQNPHILERAQNEVDEVTGGERITVQHLGR
LTYIDAILKESLRLMPTAPAFTVTPKKPEVLGGAWAIDAGQAVNVLLPVCLRDRSV 205405
205406
FGPDADEFRPERMLEENFSKLPPNSWKPFGNGERSCIGRAFAWQEAQLVVAMVLQTFDLV 205585
205586
PDDPSYKLRIKETLTIKPDGFRVRATLRRGQSATGLSQGSMSASGATSSVASPGPPAATG 205765
205766
AQSNPAGGQRISFFYGSNSGTCKALAHRLASSLMGRGFTEQKLAALDTVVGNLPTDQPVI 205945
205946
IVTTSYDGRPTDDAEEFVRWLESKRPVLQGVSYAVFGCGHHDWAKTFYRIPILIDDLMH 206122
206123
KAGATRLTALGTANAAVSDLFSDLELWEETNLLPALREAFPPSNSSDVESSEPHQLQICV 206302
206303
SKPRRVDMHRGLVEAKVTAVRTLTSPDSPEKRHVEFHVQGDTTWRPGDHVNILPVNPLST 206482
206483
VSRVLAYFQLAPDHSITVNSFNTQGLPSATPVSATELFSSFVELSQPATR () 206632
206695
QNLKALAMAAESKTDEQELIRLHDSYDALVRDKRVSVLDILERFPSISLPIGIFISMLPP 206874
206875
LRLRTYSLSMAPSFKPSHGSLTFSVINEPAWSGNGQYLGVGSNYLASLTPGSLLYLSPRP 207054
207055
AKDAFHLPADQFNTPIIMICAGSGLAPFMGFIQERMTWLKQGRPLAKGLLFFGCRGPHLD 207234
DLYYEELSEFEDAGVVEVHRAYSRAPDDVRAKGCRHVQHRLVTEAEAVRDHWGRNAIVYV
207415
CGSSNMARGVQTVLEEILGTLPPERYVAEIF* 207510
>CYP505F1 estExt_fgenesh1_pm.C_chr_30459 [Mycgr3:99701] Mycosphaerella
graminicola
JGI model Mycgr3/chr_3:2874198-2877434
47% to CYP505A1 AB030037 Fusarium oxysporum
49% to CYP505A2 N. crassa, 52% to 505A13 Aspergillus fumigatus
52% to CYP505G1 in this genome
MVSTKTVPRPWGLPLIGNVPSIDMGYPLGSLNSLADRYGEIYQLNLIGKEALFISTHKLFAEVCDETRFQ
KHLLAPLVQLRNVVGDGLFTAFPGETNWEIAHRTLMPAFGPLPIQSMFAEQHDIASQLVLKWARFGPDHD
IAVTDDFTRLTLDTIPLCSMDMRFNSFYHDDLHPFVDAMVGVLAAAGDRARRPDVADYVLRAQRAKFDKD
IAYLRKLSTELVARRREKGTQKKDLLNALLNNKDPKLGVGMTDDSIVDNMVTFLVAGHETTSGLLSFLFY
ELTSSPEAYKKAQQEVDEVVGSGAVNVGHLSKLPYLTACLRETLRLHSTAPAISVTALKDDIIGGQYAVK
KGQGINCLLAKIQSDPAVWGTDASEFKPERMLDEIFNKLPAHAWKPFGNGVRGCIGRAFAWQEALLTVAL
LLQIFNFRKTDPSYKLEVAMTLTIKPKNFTMRATMRDPSILERLGAVSVSGEVSSAKATTQHARTSSLAA
VESAGTTINILYGSNTGTCESLASSLGSTAKSRGYKAYVDTLDNGMSSISADKPTVIITASYEGQPPDNA
MKFSKWLNSDESSSLAKSKYAVFGVGNREWVTTYQRQPKLIDEVMGQKGAESLVDRGIADVCDGDIFNAF
DRWTDEKLWPAVDAAFSAGKSAASSDEGLSITVDTESRVKQLRQDVQAAVVQDVKLLTAPGKPAKRHIQL
KLPPGTDYKAGDYLTVLPVNPEPSVRRAMARFKLTWDATITIDSSSQTTIPTGRPISAFDVFASYVELGQ
PATDKQISQLASTIPDEKDRQSLTNTSLKPAAKTKTPSLLELLETYPTATYTLSQFLAAVPSMRTRQYSI
SSSPLVDPGSASLTYSVLDAPANPASPADGKRFLGVASNYMARAQPGDHIQVALRPSHAGFHLPSDDSKP
VLMACAGTGLAPFRAFVEERAVKIAAGKNLGPAILFFGCNAPDEDDMYRSEFDAWTKSGAVDVRRAYTFA
PEKSEGCKFVQHRVWHDRKEMVELIQKDACMYICGAGVVGAALVDVVQRIYVEYKGCTEEEAKKWFEGLR
GERYWSDIFS*
>CYP505G1 estExt_fgenesh1_pm.C_chr_70227 [Mycgr3:100796] Mycosphaerella
graminicola
JGI gene model Mycgr3/chr_7:1478709-1482337
52% to CYP505F1 in this genome, 46% to 505A1
Fusarium oxysporum
MTHPIPSPRAYPFIGNLLDIDASNPTASLAHLADVYGPIFKIRVPKERLWATNYAVASELFDEKRFQKAV
TGPLEQVRNLTGDGLFTAYQGEPAWQLAHRLLMPAFGPLPIKSMFP
EMQDIVNQMVLKWARFGLDREIDV
AD DFTRLTLDSIAICAMGDRFNSFYHEGQHPFVDAMVGTLSGSFARSRRLPLPSSFYAKEDQAYAKDIAT
CENLAKELLTNRRANPTDKKDLLNAMINAEDPKTGERLSDPVIIRNMVTFLIAGHETTSGLLSFLFYLLL
ETPPAYRKLQEEIDTVVGKRTVTVDDMGKLPYVEACLRETLRLYSTAPAFTLTAKGDQIIDEKYLIKDGQ
HISVLLSKFHRDPEVYGPDVEAFRPERMYKDAFTNLPPNAWKPFGNGSRACIGRPFAWQEAILAVAVLVQ
TFQFTKADPNYKLEIQTALTIKPKGFFMKAKPRNADFLDTAAQLGEAPKAKVQAPGVRGKSDVDKSKLQP
LEILYGSNTGTCEALAQALASASPDHGFNATVRSLDEGVSSAKKNHPVVIFTASYEGQPPDNAGHFVEWV
TSSSNAGIKDVPYAVFGVGNREWAATYQRIPKVVDEALAKIGAKRLVDREECDVAADKVFEKCDDWQEFK
LWPALRKQFN VDAPRDAGGLKGLDLSLDTQ MRSTILRQDTLIGEVTETKLLTSPGAPRKRHIGIRLPSGT
QYRAG
DYLAVLPVNPPALVKRVLNRFQLPWDAMITIAESNTTSLPKGMPISAHDTLASLVEIESPVSSRV
AASVSKSIPDEKAASELEEKLQKGNLTMSLLDLLEQYPEAQISFAQFLASLPPMRIRQYSISSSPLADPS
VATLTYSVIDAPNRSGGKQNFVGICTTYMERLSVGDRMHISLKPSRTGFHLPADDHSAIIMACAGTGLAP
FRAFVAERAIKKAHGGEVGPALLFYGLNRPEEDDMYRDEFDAWEKEGVVSVRRAYTFKPEESHGTKFVQE
RLWHDREDVVDLFRQDAKLYLCGAGVVGQGVEGVMTRIRSEMTGENEETAKQWVQDLKGDRFWSDVFS*
>CYP505G2P Fusarium verticillioides
53% to CYP505G1, pseudogene, possible orthoog
of CYP505G1 Fusarium oxysporum
FVEG_11770
MSKQIPNPKGYPFIGNVLDVNPDHPQESLAQISESYGPIFRLYLPAERIFVANY
ALAKDLFDEARFEKAVIGPLEQVRNATKDGLFTAYPGEHNWEVAHR
TLMPAFGPLSIQNMFG (small deletion here about 26
aa)
DFTKLTLDSIAL (2)
CAMGERFNSFYHDDNHPFVGAMNNMLVESFARSRRPAFASAVMKASNA
RYESDIAELENISRELLEARRQNP
VDKKDLLNAMINGRDPKTGEGLGDDAIIRNMITFLIAGHETTSGLLSFLF
YLLLETPSALRRAVEEVDRVLGSQLITVAHLAKLPYIDACLKETLRLYPT
APGFTLRAKGDQVLNNEYTIKDKECVTILLARLHRDPDVYGPDAEDFDP
SRMLPDKFNKLPANTWK (0)
PFGHGVRACIGRPFAIQEAILATATILQTFHITKDNPSYQLQIRTA
LTIKPQGFKIRAKLRNPSFLEGAELGHGSGSGNAASSKTPSKAHAAKQE
GNSEPISIFFGSNTGTCEALAQSVASSAEENGYAPKVDSLDNAISSLKPNV
PVVVITGSYEGQPPDNAAHFVEWLASLSSGELSKVPYAVFGVGN
(1)
EEWHNTYQRIPSLIDEQLEKAGATRLVSRAAIDVAKTNCLETIEEWQESELW
PALQKNSGKSSRTASGGARELKLDY&VLG &
LRQSLLRQDVMTAQVSRDAAADQAWAA*ESVTWYRLPSETT*PGCDYLAVLPLN
HPDVVHRVMRRFHLPWDTTVCIDGSKSTSLPTGKPFSVQNLLAGMLELGQPVTE
RQALQLTETIPDKTKSDELKERVKQGNLSKLNTTLLDLLEDYPSAT
YSFGQYLAALPALHLRQYSISSSPVASASPSECSLTYSVIDAPAKGNSQGHRYLG
ASTYLERLQPGDHIQVGVRPSRSGFHLPAESKTPIVMACAGTGL
APFYGFVAERAVKKSQGLTVGTAQLFYGCNGPDEDDLYRGQFDEWERDGVVKVYRA
YTFAPEKSENCKFVQDRMWFDRQDIVTSFREGAQFYICGAGIVG
SSIQKVLAKIRAEAADCDQESASVWLDSMKGERYWADVFA
>CYP505H1 Fusarium oxysporum
46% to CYP505B2
FOXG_15285
MAVKQESKKHDEKHKGQIPGPKGLPIIGNLLDIDVTNSLQSIIDMAKDYPKLFALNVGGNTEIMICSRELMDELSDEARF
HKLVVGGVEKLRPLAGDGLFSAQHNNQEWAIAHRILMPLFGPLTIREMF
PDMRDISEQLCLKWARAGPSATIDV GNDFTR
LTLDTIALCTMGFRFNSFYSNDKMHPFVESMVAALVDAEKQSMLPDVVQSFRLRAQSHFKKHAAVMKSTCHEILEQRRKN
PVEGKDLLNAMMNGKDPKTGMGMSDGNIVDNLITFLIAGHETTSGLLSFAFYYLLENPEKLQKAREEVDEVLGDENLTAD
HLPKMPYINMIFRETLRLMPTAPGFYVTPFKDEVIGGQYNVSAGDPLFLFLHMIHRDPEVWGPDAEEFRP
ERMADEQFNK
LPKNAWKPFGNGMRGCIG
REFAWQEAQVVTIMLLQNFDMVKADPNYKLKIKQS
LTIKPDGFNMKVKLREGRDLTNLFKNP
SLASSKQPSLSSRMNLKISQKDLKPISIFYGSNTGTCEALAERLSADCATFGFMPSKPLPLDEATRNLSKDGPNIILAAS
YDGKPSDNATEFTKWAESLQPGELDGIQFAVFGCGH
KDWVSTLYRIPKILDKCLAAAGADRLVDIGLTDASTGRLYPDFD
DWAHSKLFPELASRHGITLDHAPDSLELSVTINQSQRNDIGGNFKRAEVVENTLLTSPGVPRKHSLLLKLPKDMAYTPGD
HVL
VLPKNPPQLVDRVMTCFGVDDDTVLTVSSQRPTFLPTGTPILASNLFSTLVELSQTVSRTSLKRLVDFAGNDGTKGE
IQSLAGDRYDAEIDQQRMSILDILRKYPSINMPLSTFLSMLPQMRPRTYSFASTPEWKAGHGSLLFSVVEATEASGSSLA
RPGGLATNYMAQLRPGDSILVEPRPCRPELRTAMITELNVPIVMIAVGAGLAPFLGFMQKRYLQTQNSGHLPNSPCTLFF
GCRGAKMDDICRDTLDEYSRAGVVSIHRAFSRDWDSPYKYVQHLVAKHADTLARLWGQGAIVMICSGKKVSDDVFDVLGP
ILHSEDRRLNTTRASDWKTWREEVSKERLILEVFG*
>CYP505H1 Fusarium verticillioides
94% to CYP505H1 Fusarium oxysporum = ortholog
FVEG_12598
MAAKQKSKKHDEKHKGQIPGPKGLPVIGNLLDIDVTNSLQSIIDMAKDY
PKLFALNVGGNTEIMICSRDLMDELADESRFHKLVVGGVEKLRPLAGDGLF
SAQHNNQEWAIAHRILMPLFGPLTIREMLPDMRDISEQLCLKWARLGSSA
TIDVANDFTRLTLDTIALCTMGFRFNSFYSNEKMHPFVESMVAALVDADK
QSMLPDVVQSFRLRAQSHFKKNAAVMKTTCHDILDQRRKNPVEGKDLLNA
MMSGKDPKTGMGMSDGNIVDNLITFLVAGHETTSGLLSFAFYYLLENPEK
LQKAREEVDEVLGDDAITADHLPKMPYINMIFRETLRLMPTAPGFYVTPF
KDEVIGGQYNVSAGDPLFLFLHMIHRDPEVWGPDAEEFRPERMADEHFNK
LPKNAWKPFGNGMRGCIGREFAWQEAQIVTIMLLQNFDMVKADPNYQLK
IKQSLTIKPDGFNMKVKLREGRDLTNLFKNPSMASSKQPSLSSRKNLNISQ
KDLKPISIFYGSNTGTCEALAERLSADCATFGFMPSKPLPLDDATRNMS
KEGPNIILAASYDGKPSDNATEFMKWAEALQPGELEGTQFAVFGCGHKDWV
STLYRIPKVLDKCLADAGADRLVDIGLTDASTGRLYPDFDDWAHSKLFP
ELASRHGITLDHEPDSLELSVTVNQSQRNDIGGNFQRAEVVENTLLTSPGV
PRKYSLLLKLPKDMAYTPGDHVLILPKNPPQLVERVMTCFGVDDDTVLTV
SSQRPTFLPTGTPILASSLFSTLVELSQTVSRTSLKRLVDFAGNEETKAE
IQSLAGDRYDVEIDEQRMSILDILRKYPSINMPLSTFLSMLPQMRPRTYS
FASTPEWKPGHGSLLFSVVEATEASGSSLARPGGLATNYMAQLRPGDSVL
VEPRPCRVELRTAMTTELNVPIVMIAVGAGLAPFLGFMQKRYLQKNSGQL
SNSSSTLFFGCRGAKMDDICRDTLDEYSRAGVVTIHRAFSRDWDSPHKYV
QHLVAKHADTLARLWGQGAIVMVCSGKKVSDDVFDVLGPILHSEDRRLNT
TRASDWKTWREGVSKERLILEVFG*
>CYP505J1 Aspergillus clavatus
46% to CYP505A15
ACLA_032390
MSEIPQPPGLPYIGSLLEIDPKYTVKSLRRLGDIHGPIYRLSIVNITRIVVSNHELFDELCDESRFVKSVSGPLSQMRNL
VHDSLFTAHPNEQNWGIAHRIIVPAFGPVPIQDMFHGIYDIASQLILKWARQGPSKPINVQEDCTRFTLDAVTLCAMGVR
LNSLYSEEKPPFAQAMDGFMRESNYRAQRPAFATRLLWWYRQQYDRDIDFIRKFAKELINARRKNPTENQDILNVLIKGR
DPETGRQMSEESIIDNMVTFLIAGHETTSGGIAFLLYYLVKSPDVWQKVQNEVDAVVGSGRITSKHLSKLRYITACVRES
LRLWPTIPVIAFKPKDRQNPTVIGKDKYSLMPGQTIIALLPAIHRDPDVWGEDADEFRPERMVDEELSALPKNAWKAFGN
GARSCIGRPFAMTEMVLITALLAQNFDVEQHDPDYELDIDQIVTLRLRNFFLRVKPRPGIDAVQLANRLFNDQEAKSRPG
PEATMTPAVRDKLKPITVLYGSNTGTCESLARQFSRDASRYGFNPTMLPLDSALEKLPTDWPVIILAASYEGQPAANAAK
FVSWLQKIKKPILSGVSFAVFGCGNRDWTATFHRIPKLIDRLLSDAGAHRLLELGLADVSSMVVQETFETWYGNQLWPAL
RAKYTISELRPLPSKLTVEFTNHLRQATNGQEFIEASVIENKLLTASGVKAKRHLELALPPNAEYTVGDYLHILPMNPPV
TVQRAMGFFRLAEGTYMKVTGGLSTVLPIGKEISVEEALSRYVELSQPATQKILERISLSTPVLTEREKLSHQAASSTSL
QDKRISILDLLEHAPSSTISFADFISMLQPLRARPYSISSSPLNCARSCSLTVSIVDNPEPTARETRVLGISTHYITRLK
PDQRILCSIRPSNSGFTFPDNPETTPMVMICVGSGIAPFRAFVQERVCRAEKGQKLAPGLLFIGCKSPKHDRLYGSELDQ
LEEAGIVTVRYAYSGLPYRKHVQDKLWDERETLVDMYKGEARFYLCGPVELRDSVLAVARRIYMATVEANGEVRGEDEYQ
NWLAKMNKGRFAADTFA*
>CYP505K1 Mycosphaerella fijiensis
48% to CYP505A2 N.
crassa
e_gw1.1.1150.1
MSKSPRDNIPSPPGLPIVGNLLDIQDEVPIRGLENIADTYGGMFKLNIMGRERLFAANVALLDELCDESRFWKAPGDGLN
PLNQGGGGGSKGLFTAESEETMDWQLAHRILMPAFGPLAIQDMFDEMHDIASQLVLKWARLGPSYSILVTSDFTRLTLDT
IALCAMDYRFNSFYQDELHPFVQAMNTSLAFSSDRTKLGSIVKRLLPWDKSIQKLAADRQYMTSVSKELVELRRNNPTNK
RDLLNAMVLGKDPNTSEKMSDGLIASNMTTFLIAGHETTSGLLSFAFLFLLQHPDAYFKAQQEVDRVLGRGKIEVRHLQE
LKYIDAVFRETLRLCPTAPAFTRSIRKDNPNDVEELLGGKYAINRDDKVLCLLSKCQRDPEVYGEDANDFKPERMLGDAF
NKLPKSAWKPFGTGLRSCIGRAFAWQEAQLAMAMILQNFNIRLDDPGYQMRIKQTLTIKPEGLYMRATLRDGISAATLQT
ALASSPDAVRSAIEDTISRADSGMEDAKPMTILYGSNTGESLPLGSHGTCTALAQKLSLEGRRHGFDARVMELNDAVDAI
PRDGQPVVLITASYEGQPTDNAAQFVKWLEVMPPGESRFEGVNFAVFGCGHRDWTGTFHRIPKLVDELFKKHGATQTVRA
GFADAAAGDIFSQFEDWTDRSFWPSVSPSSGAAQEAPELEMDVATRERSTYLRQDVRKGIVKSSWCLTADGEPEKRHLEI
KLPDNMTYEAGDYLAILPLNPQQTVTRVMKHFKISALATTTIKPGAATFLPTGVPLSIVELLKGFVELSLPATKRDIQAC
IACTSDTTEKEELRALQSESAFRELDESHVSLLDLLERYTSIGLGFNTFIAMLQPLKPRLYSISSSPLVDATSCTVTYGV
IDEDAKSGNGRYVGVTGSYLSGLMTGDEILVSVRATNRYFHLPAEISQTPILMFGAGTGIAPFRGFIQERAQQIAAGRSL
APAIMYMGCRSSSSDRLYSDEMDKWVKHGVVDIRYAFSQESHASEGCKYIQDRMWKEREDVIRLWRDGAKVFVCGGPAVC
EGLGDVSRKLLLESMKSRGQEMSEKEAELWFRERRNVRYVVDVFA*
>CYP505L1 Mycosphaerella fijiensis
46% to CYP505A2 N. crassa
46% to CYP505K1 Mycosphaerella fijiensis
estExt_fgenesh1_pg.C_180062
MASNVPQPKAWPIIGNVLDVDTVNMTQSFERLADKYGEIYKLDLLGKPTYVISSVALVAEVCDEKRFCKKIDTFLNQLRL
AVGDGLFTAHNHEHNWGVAHRALMPAFGPLPIQAMYDEMYDIASQLVSKWARDGADHEINVTDDMTRLTLDSIALCAMDY
RFNSFYHEEVHEFIRAMGDVLLESGKRAMRSKIEAWLNPSAEKKFFADIATLKKVAQQCIDRRRAGPGKKDLLDAMLNGK
DPKTGEKLSDESIINNMITFLVAGHETTSGMLSFTLFYLLKNPETLQRAQQEVDSVVGSGPIEFKHIKELKYIEAALREA
LRLCPTTVGFSVGPVPGTKGPVTLAGKYVLPPDAVIMILGTRSGRDPKVFGEDAAEFKPERMHDEHFNKLPPGAWKPFGN
GMRGCIGRPFAWQEAILALGIILQNFNLRFADPSYELKIAETLTIKPDNLLIKAQLRDGIDPIQLSKKLHGEIRTAAREE
PAKHLASSKSSGDSGQLTIFFGSSAGTCEGLAQSLAASARVRGFDTVVKSLDAAVDRFPKDHPVIIITCTYEGQPPDNAK
IFVEWLKTADRSKFEGAQVTIFGCGHRDWVSTYQKMPRTIEGELTAKGAALLAPRGETDTSQGTILDDFDAWTSRLWPSI
SADGKEYSSASSLELRLSTNSRASHLHHKVWDAKVVSNRRITSLEAPEKRHVTISLPRDMQYDAGDYLAVLPLNNQQLVS
RVLRRFSLPWDTAMTITSGSHATIPENRELPVALILSGYIELGARASRKSRDVLSEHSKLSLADERGSIIDILERHPDIS
IPFGTFLELHMPLRLRQYSISSSPLADPSLATITFSVIESDEHIGTATSYLKSLEPGSTLQVAVKKSSAAFHLPLDESIP
VIMVAAGTGLAPFRGFLQERAVKAEAGRQLGEALLFVGCRDPNQDKIFAEELAQWENLGVVKVRYAYSRASEQSDGCRYV
QDRVYKEAAEIARLFDLGARIYICGSGAMGRSVSDVAVRLLVEEAEDKGEKLSEEDARLRWEKWRGERYALDVFD*
>CYP506A1 Fusarium oxysporum
93% to CYP506A1P rev Gibberella moniliformis
FOXG_10952 revised
MSAKLPFQLSTGAMYKHPQFPSLIA
AGVMTFTSILLVALKFWSSSATPKVKILLQDEIKSARHRALEYCFNPRAVMAKGYAK
(0)
FKNEVFGLDTQD (1)
GVKLVIPPNFLDELKSHPALSFKVSIDN (0)
DMQIEYTHFGGPAEYVIHAIKANLTGSL (1)
LHDRVLRLIATNNARVFQGTAASLDEEWLEASTGYVLACFDCIRALKQWH
PWLRPLVYILIPERAAIKDQWTKGRKRVMASMRERQEKGGNLEDPPTMLDHLSNGRNEHIADDVELQLLHQMTLIAVGTV
TTFSSTTQAIYDLVAHPEYIPILREEVESVPRDPNGNFTKDSTVAMNKLDSFLKESQRFNSPDL
(1)
TTFQRAAIADMKLPDGTFVPKG
TKLEINTCSIHKDHELYGNPELFDGLRFHKWRKAPGKGKKYMYSSSGTDDLSWGFGRHACPGRYLSAINIKLIMAELLMN
YDIKLPDGVSRPKNIEFEVLASLNACANA*
>CYP506A1
Fusarium oxysporum fragment X82490
MAPMLRPLVYRFIPERARIKDQWTKGRKRVMASMRERQEKGGNL
EDPPTMLDHLSNGRNEHIADDVELQLLHQMTLIAVGTVTTFSSTTQAIYDLVAHPEYI
TILREEVESVPRDPNGNFTKDSTVAMDKLDSFLKESQRFNSPDLSM
SNLKNYKLCESL
TGHSNLPTR
TIADMKLPDGTFVPKGTKLEINTCSIHKDHKLYENPEQFDGLRFHKWRK
APGKEKRYMYSSSGTDDLSWGFGRHACPGRYLSAINIKLIMAELLMNYDIKLPDGLSR
PKNIEFEVLASLNACANA
>CYP506A1P Gibberella moniliformis 7600
AAIM01003201.1 cont2.3201, whole genome shotgun
Note this seq has only 1 aa diff to 506A2 at 10017, but
then a large gap
Like a pseudogene
77% to 506A2
also = Fusarium verticillioides FVEG_09850
10017 DMQIEYTHFGGPAEYVIHAIKANLTGSL
(1)
FHDKVLR
10311
LIATNNARVFQGTTASLDEEWLAASTGYVLACFDCIRALKQWHPYLRPLVYRFIPERAAI 10490
10491
KDQWAKGRKRVMASMRERQEKGGNLEDPPTMLDHLSNGRNEHIRDDVELQLLHQMTLI 10664
10665
AVGTVTTFSSTTQAIYDLVAHPEYIPILREEVESVPRDENGNFTKESTVAMDKLDSFLKE 10844
10845
SQRFNSPDL (1)
TTFQRAAIADMTLPDGTFVPKGTKLEINTCSIHK 11024
11025
DHELYENPEEFNGLRFHEWRKEPGKEKKYMYSSSGTDDLSWGFGRHACPGRYLSAINI 11198
11199
KLIMAELLINYDIKLPDGVSRPENIEFEVLV
11291
SLNEMVLGSVADVGSAPLNRISRSFSRIGIIRWNGVCLVR*
>CYP506A2b Fusarium graminearum
AACM01000093 Gibberella zeae
MAGTTFAELHLAFYQWIDETLDHPLGRYFM
AGVGSSLVVLLVAIAAFCSRSKTPNVPILLQDEIGNARKRALEYCFNPREVMEKGYKK
(0)
FKNEVFGLDTQD (1)
GLKLVIPPSYLDALKSHPALSFKASIDN (0)
DMQIEYTHFGGPPEYVIHAIKANLTGSL
VHDRVLRLIATNNARAFQGTAASEDEEWLSASTGYVLACFDCIRALKQW
HPWLRPLVYRLIPERAAIKDQWAK
GRKRVMASMKERQQKGGNIEDPPTMLDHLSNGKHEGMANDIEKQLVHQMNLIAVGTVT
TYSSTTQAIYDLATHPEYVPILRQEVESVSRDANGNFTRDSTLAMEKLDSFIKESQRF
HSPDL
TTFQRAAIADMTLPDGTFVPKGTKLEINTCSIHKDKDLYENPGDFDALRFYKMRQAPGQ
EAKYQYFS
VGREDLSWGFGRHACPGRYLSAINIKLIMAELLMNYDIKLCDGASRPPNIEFEVLVSCTTEPGTQP*
>CYP506-un1 pseudogene Nectria haematococca
gw1.28.129.1
probably from a CYP506 sequence, subfamily not assigned
Necha1/scaffold_28:447825-448775
35% to 506A2 mid to heme, 38% to AAIM01003201.1
Gibberella moniliformis
the top part of this seq seems to be missing
probable pseudogene, check 506A2 for TFQRAAIADMTL,
may extend last exon
410941 HAGGPGESGLHAIQGHIVAS 410882
LVSRISARIFHSAASADNDHWLDIASEHVHSAVVWTENLKKWPAMLRPLVYRFVKGRGYMMQRFEEGKAL
VAQTLENKKANGGKPLSDPQSLLDYLYESGLGPDDVEAHTIAQINLCVAAIXSMAATVTQCLMDLATHPE
YAPELIEEIKTVVEKNNGVVDKRVLTELWKLDSFIKETQRLNPPDL
(1)
TSFQRKALSDMTLSNGLRIPKGAR
IVLPTGAINMDREFFEDPQTFDGFRYFYRIRTANEAARNTNQMVTVGKKDLTWGYGKHACPG
RYIAEVAMKLLVVEFLMRYDIRLPENVK ERPKNIEFEGLVCCFHP*
MNNFIFKRLNVKEFYEAETKKLVENGHEFHLRLERT
GYVIHTCN
>CYP507A1 N. crassa
AABX01000414.1 cont3.575 NCU09185.1 (version3)
98714
MALTELLGALPLVSSGMSKLQVAAIYLAISFVSWYIISSFTDWY
RLKAFPGPPTTGFSNLWAARAIWTGKAHKIFPATQEKYGPITRI
GPNALMVCDAATVVHINGVRGGYARSQDFYDCIRMDPWDHTVLS
ESDSAMHNERKTKVYAGYHGKGEMDMEKDVDMVIAEAVELVRKK
YMNSAATSGSKPPLDYTRIARYIAVDSVTQTGFGKAWGDVREEK
DHFGWLGFADMIVGYLHSLAYVPAISKIVISTPLMVLLGPKPTD
KSGIGAFLG (2)
97896
97821
LIEREVARRYKDGSAKGTPLKADTGRSSML (0) 97732
97669
DEWVKNGISQRTAVLEVSAQLPAGSDTTASALQGTMLYLLSTPS
AYIRLKSEISTAIRTGLISSSSIITDQEARKLPYLQAVLYEAIR
MMPPLMNGFPRQVPAGGDTICGRFVPGGTDIFVNYVGMLRDKSV
FGEDANVFRPERYLEGDEERRNRMWKTTDLAFSHGRWRCLGQRL
AWVQLQKVVVE (0)
97109
97044
FMRNFEMQIVDPMHPCRLRCYCTPEMDDLMVKVTEAKWD* 96925
>CYP509A1
AF249299 Cunninghamella elegans
MNNFIFKRLNVKEFYEAETKKLVENGHEFHLRLERTGYVIHTCN
PQAIKEILLKGDKFPKYDYNTSNNEDGSFFHEFVGFENVLMTNGSTWKKHRMIVNPAF
KTALPSRLFGDCTRDLFKLWDNEYANEPFDSDIHNITERLTLQIIGKAAFDFDFNAIL
DEKSIWKQTYDGINKAASDPLFILFPILEEKFLWLFPKRQQSFKLLNEWKKMLLSIIE
KKREAIQNNVDHGVEEAEKDLLTLMIESEHRGEGALSNEELLSDLIIFFIAGHDTTAF
ALSAAIYYLAKHPDIQEKARQEAISVLCPNGEVDEDIFPTTEDTKHFVYINQIMKETL
RINGSVLFLLSPRLVTQDVNLSGVFIPKGSQINVNIHEVHHNPNVWHDPETFDPDRWA
SNGEAEQLAGKGMAWVPFSNGNRQCIGMNFSLLEQRVILGSLLRKYEWTLPEDSIHQD
YMVNKFNLIPKPIDLKIRFKRRY
>CYP509B1 Rhizopus oryzae RA 99-880 (Zygomycete fungus, Mucoromycotina)
AACW02000089.1 cont3.89
P450-15 in CYP56 clan
43% to CYP509A1
RO3G_05802.1 revised
MIFEVIQEIIQPWIESNVRILIVFGIVLAFYALVQRYNRPPAALAHLPYVSFFSFLK
YGFKDEVYDTYAKEKLLPLLKAKG
(1)
291331
GWVVRLADPVAIKQFTLKQGK (2)
GLFASPTIQGWVSIHLNSNHEIPSIEHT (instead of the third exon above)
(?)FPKAMSNAGEEGTLIHRF
291158
291157
IGGPNIVFLSGPDWKRHRK (0)
IANLAFQRSMPVQLFGDLAKRML
290978
290977
RSMEKTEEDAIDVNDLFRRFTLDAIGNGGF (1)
GFDFHAIEDKE 290807
290806
SKWVEYYESVMQGMASPFYIVFPAFDTKYVHWFRKRKQLHDNLSKLMENMDEIIEKKRKL 290627
290626
VYENGQGESKEKDLLTLMIESEMKSEGESLSNEELR (0) 290522
290469
SNLCIFFLAGHDTTANTLAAIIYELAKNKEIQEKARKEAIRILGDGPEDTAPTAEQL 290299
290298
KELDYINMIIKE (0) 290263
290192 TLRRHPPAYVTTDRVVQNDLVLGDVHIPKGSDLCLDIYSLHHNADIWSNPFEFNPERFAPGGEADS 290019
290018
QRGIAWAPFSSGGRMCVGMNFSLTEQRVLIPML (1) 289923
289869
LKKYTWSLPNDSSHQHELQKRGIAWGLVTFKDKVKIEFKKRN* 289741
>CYP509C1 P450-32 in CYP56 clan Rhizopus oryzae (Zygomycete
fungus, Mucoromycotina)
93% to P450-33, 90% to P450-30var1, 89% to
P450-31, 87% to P450-34_var1
87% to P450-29, 84% to P450-7_var1, 65% to
P450-39, 59% to P450-36
56% to P450-42, 53% to P450-20a, 53% to
P450-12, 40% to 509B1 =P450-15, 38% to CYP509A1
RO3G_10680.1
MEDLVTKYNMALEGALPLFQKRSKSSYIVAAILLITVKQIYSFFRVPTNLRHLPCVSFFAMAKSLLTCEPPYNRFKRITFPAIQEGNGFYVSKIPTGWTVYVANPVAAKQLLLKSNNFPKSHYGLDTIGEKSTAVQFVGRDNVVLSNGEIWKKQRKIMNPVFHRSMPIKTVASLVPLLFSAIEEANGRIMITPKMKDFTLDALGLTIFDFDFKALQGDPDNWTSIYRLITRSIFDPISYVFCALEPLLVYVYPKRRRSVDAVAKINAKFDQVISKKREELQNGIFSNKPDNEKDLVTLMLEAGMQEDVSITNEELRHNMAVLFLAGHDSTSNTLSFCLYHLAKNKRAQQKLREEIINILGDDDIDIVPSLEELKQMKYMNMVIKETLRLGMPLDLLTPRKTVEDTFVADTFIPKDTVIAVDAGALHRDPRSWKDPDEFVPERFEDDGEQNSHEGLTWVPFSNGTRQCIGMNFSLMEQRLTLTMLLRKYEVDLPKDSIHYDHIIYEQPSYVCPESLELIFTKRY
>CYP509C2 P450-33 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
93% to P450-32 in CYP56 clan
RO3G_10685.1 revised
MEDLVTKYNMTLEGVLPLFQKRSKSSYIVAAILLITVKQIYSFFRVPTNLRHFPCVSFFAMAKSLLTCEPPYNRFKRITFPAIQEGNGFYVSKIPTGWTVYVANPVAAKQLLLKSDNFPKSHRRFDTIGEKSTGVQFVGRDNVVLSNGEIWKKQRKIMNPVFHRSMPIKTVASLVPLLFSAIEEANGKIPINPRMKDFTLDALGLTIFDFDFKALQGDPDHWTSTYRLVIQSISDPISNVFSALEPLLVYVYPKRRRSVDAVAKINAKFDQVISKKREELQNGIFSNKPDNEKDLVTLMLEAGMQEDVSITNEELRHNMAVLFLAGHDSTSNTLSFCLYHLAKNKRAQQKLREEIINILGDDDIDIVPSLEELKQMKYMNMVIKENLRINTPLDLLLPRKTAEDTFLADTFIPKDTIIVIDVGALQRDPRSWKDPDEFVPERFEDDGEQNSHEGLTWVPFSNGTRQCIGMNFSLMEQRLTLTMLLRKYEVDLPKDSIHYDHIIYEQPSYVCPESLELIFTKRY
>CYP509C3 P450-30var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
87% to P450-29 in the CYP56 clan
RO3G_10670.1 revised
MDDLVTKYNMTLEGVLPLFQKRSKSSYIVAAILLITVKQIYSFFRVPTNLRHLPIVSFFAMAKSFLTCEPPYSRFKRITFPAIQEGNGFYVSKIPTGWTVYVANPVAAKQLLLKSDNFPKSHRRFDTIGEKSTGVQFVGRDNVVLSNGEIWKKQRKIMNPVFHRSMPIKTVASLVPLLFSAIEEANGRIPINPRMKDFTLDALGLTIFGFDFKALQGDPDHWTSIYRLVIQSISDPISNVFSALEPLLAYVYPKRRRSVDAVAKINAKFDQVISKKREELQNGICSNKPDNEKDLVTLMLEAGMQEDVSITNEELRHNMAALFLAGHASTSSAVSFCLYHLAKNKRVQQKLREEIINILGNGDMDIVPSLEELKQMKYMNMVIKENLRLNMVLDLLLPRKTAEDIFLAGTFIPKDTNIAVDVGALQRDPRSWKDPDEFVPERFEDDGEQNSHEGLTWVPFSNGTRQCIGMNFSLMEQRLTLTMLLRKYEVDLPKDSIHYDHIIFEKPTYSCPESLELIFTKRY
>CYP509C4 P450-31 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
89% to P450-30var1 in the CYP56 clan
RO3G_10674.1 revised
MDDLVTKYNMTLEGVLPLFQKRSKSSYIVAAILLITVKQIYSFFRVPTNLRHFPCVSFFAMAKSLLTCEPPYSRFKRITFPAIQEGNGFYVSKIPTGWTIYVANPVAAKQLLLKSDNFPKSHSRIDTLGEKYMGVQFMGRDNVAISNGEVWKKQRKIMNPVFHRSMPIKTVASLVPLLFSAIEEANGRIPITPKMKDFTLDALGLTIFDFDFKALQGDPDHWTSAYRLMMQSLFHPISYVFSALEPLLVYVYPKRRRSANAVAKLNAMFDRLIEKKREELQNGICSNKPDNEKDLVTLMLEAGMQEDVSITNEELRHNMAVLFLAGHDSTSNTLSFCLYHLAKNKRAQQKLREEIINILGDDDIDIVPSLEELKQMKYINMVIKETLRLNTPLDLLTPRKTVEDIFLADTFIPKDTNIAVDVGALHRDLRNWKDPDEFIPERFEDDGEQKDHEGLTWAPFSNGTRQCIGMNFSLMEQRLVLTMLLRKYEVDLPKDSIHYDHIIFEKPTYSCPESLELIFTKRY
>CYP509C5 P450-34_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
87% to P450-32 in CYP56 clan
RO3G_10705.1 revised
MEGLVTKYNMAFEGLLPLFQKRSKSSYIVAAILLITVKQIYSFFRVPTNLRHLPSVPFFAMAKSFLTCEPPYSRFKRITYPAIQEGNGFYVSKIPTGWTIYVANPVAAKQLLMKSNNFPKSHYGLDSIGEKSTVVQFVGHDNVALSNGEVWKKQRKVMNPVFHRSMPIKTVASLVPLFFSIIEEANGRIPINPKMKDFTLDALGLTIFDFEFKALQGDPDNWTSVYRLVTRSIFDPLSFVCNTIESLLTYVYPKKRKGAYAVVKLNAKFDQLIDKKREKLRNGIFSNKPDNEKDLVTLMLE
EDISITNEELRHHMALLFLAGDDSVSNTISFCLYNLAKNKRAQQKLREEIINILGDDDMDIVPSLEELKQMKYMNMVIKETLRLDMPLDLLLPRKTVEDMFLADTFIPKDTDIAVDAGALHRDPRSWKDPDEFVPERFEDDGEQKDHEGLTWVPFSNGTRQCIGMNFSLMEQRLVLTMLLRKYEVDVPKDSIHYDHIMYEQPTYICPESLELIFTKRY
>CYP509C6 P450-29 in the CYP56 clan Rhizopus oryzae (Zygomycete
fungus, Mucoromycotina)
83% to P450-7_var1
RO3G_10668.1
MESLVTRYNMALEGLLPLFQKRSKSSYIVAAILLITVKQIYSFFRVPTNLRHLPIVSFFAMVKSFLTSEPPYSRFKRITFPAIQKGNGFYVSKIPVGWTVYVANPVAAKQLLLKSDNFPKSHFGLDAIGEKSTAVQFVGRDNIFLSNGEVWKKQRKIMNPVFHRSMPIKTVASLVPLLFSAIEEANGRIMITPKMKDFTLDALGLTIFDFDFKALQGDPDHWTSIYRLVTRSIFDPISYVCSAMENFLTYTYPTKRKGFNAVVKLNAKFDRLIEKKREELQNGIFSNKPDNEKDLVTLMLEAGMQEDISITNEELRHNMAALFLAGDDSISNALSLCLYHLAKNKRVQQKLREEIINILGNGDMDIVPSLEELKQMKYMNMVIKENLRLNMPVDVLLPRKTAEDIFLAGTFIPKDTIIVIDVGALHRDPRSWKDPDEFVPERFEDDGEQNSHEGLTWIPFGNGTRQCIGMNFSLMEQRLILTMLLRKYEVDLPKNSIHYDHIVYEHPTYICPESLELIFTKRY
>CYP509C7P P450-7_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
37% to CYP509B1 Rhizopus oryzae, in the CYP56
clan
P450-7_var1 has a stop codon in the I-helix
86% to P450-33, 85% to P450-32, 84% to
P450-30var1, 84% to P450-31
84% to P450-29, 83% TO P450-34_var1, 62% TO
P450-39,
58% TO P450-36, 53% TO P450-20a, 55% TO
P450-42, 53% TO P450-12
RO3G_04442.1 revised
MEGLVTRYNIALEGLLPLFQKRSKSSYIVAAILLITVKQVYSFFRVPTNLRHLPNVSFFAMAKSFLTCELPYSRFKRITFPAIQEGNGFYVSKIPIDWTVYVANPVAAKQLLMKSNNFPKSHRGFDIVGEKSPAAQFVGRDSVVLSNGEVWKK*RK
IMNPVFHRSMPIKTVASLVPLLFSAIEEANGRIHITPRMKDFTLDALGLTIL
DFEFKALQGDPDHWISTYRMVMLTLFDPILNVFSALERLLVYVYPKRRRSANAVAKLNAKFDRLIDKKREELQNGVFSNKPDNEKDLVTLMLEAGMQEDISITNEELRHHMSFLSLAGYDSTSNTLSFCLYHLAKNKRVQQKLREEIINILGDDDMDIVPSLEELKQMKYMNMVIKENLRLNMPVDLSLPRKTAEDTFLADTFIPKDTTISVDVGALHRDPKSWKDPDEFVPERFEADGEQKDHEGLTWVPFSNGTRQCIGMNFSLMKQRLTLTMLCKSILSPFFFCIIRVAKPYLFIYNEKV*
>CYP509C8 P450-39 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
66% to P450-33 in CYP56 clan
RO3G_11470.1 revised
MDVLIKKYNATFHSIISLLQKRSKASYIAAIIFLIVLKKIYSFFRVPKYLRHLPCVSYFAMAKSFLKSEPPYSRLKRITRPAIEEGRGFYVSKVPFGWALYVADPVVAKQILLKSDIFPKSTRRIETLGKNSPLFKYFGFDNVVLSNGEQWKDQRRIMNPVFHRAMPIKTMARVIPSLFSVIEDADGRIPISLRMKDFTLDVLGLAIFDFDFKALKGDPENWTSTYTQLTEALFDPIINVFASMENLLIYVVPKRRKAAKAVVRLNEKFDQLVSTKRQELQNGRFSNKPDNEKDLLTLMLEAELQGEALETSEQLRHNIAVFFLAGHETTAHSLSFCLYQIAKDKHIQQKLREEIISVLGDNHMDVEPTLEQLKQMKYLNMVIKENLRLNGPLDLLPSRKAAKDTYLKDIFVSADTEVVIDACAIHRDPKNWKNPDDFMPERFGEGGGQEDHEGLTWVPFGNGSRQCLGMNFSLMEQRLVLTMLLRKYEIDVPKDSIHYDRIQYEKPLSIAPNTLELTFTKRY
>CYP509C9 P450-36 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
60% to P450-33 in CYP56 clan
RO3G_11017.1 revised
MENQIESYRLAIEKLLPAIQKRSKLSCITFAIALIAAQQLYSFFRVPKNLRQFPRVPYFSMVKSFLKAESPTDRYKRIIHPVASKGNGFYVSKVPFLWAVYVTNPVVAKQVLLKSDIFPKNHAVFHQIGKDSPFTQFLGLDNVALSNGDVWKKQRKVMNPAFHRSLPIKTMASVVNTLFSVIDNSDGPVLITSAMQNFTLDVLGLAIFGFEFKALQGDPDNWTKTYKTVIESLFDPVMNVFATFDTLLTWVYPKRRECSVAISKMNLKFDELAKQKRAEVKSGAYANVPDHDKDLLTLMLEAMEKGEALTSQDELRHNIAVFFLAGHGTTAHTLSFCFYHLAKNKHIQRKLREEIISVLGDEPVDIVPSLEQMKHMKYMNLVIKENLRMNTPADTLFTRDTVEDINLAGHIIPKDTAISIDINAIHHDPKYWHNPEHFIPERFAEGGEQESHEGLTWLPFSNGSRQCIGMNFSLAEQRLVLAMLVRKYEIDIPKDSIHYERILFDRPGNIAPLSLGLTFTKRY
>CYP509C10 P450-42 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
60% to P450-36 in the CYP56 clan
RO3G_12495.1 revised
MELVQFVDKSYREILEKLLPVLQKKSKWSYISAAALLITIQQIYSYLHVPKKFRHIPSVSSLAMAMSFLRHESQADRFKRIIQPVMNKGNGVYVSKIPISWTVYVANPVIAKHILLKSDMYPKSHNGFKIIGPNSPFLQFIGLNNLALSNGHTWKKQRKLMNPVFHRSMPVKMMSSVLLTLFSAIEKADGTIPIAEAMKHFTLDVLGYTIFDFDFKALKGDPDDWTKTYHLVNEALADPVLNVFPSMGALLLVLLPVKRRRMAAIDKLNRKLDEMAQKKRREIQKGSYSNKLDSEKDLLTLMLEAENNGEGLLSDTELRHNLATFFLAGHETTANSLSFAFYYLAQNKHVQQKLREEVISIFGDEPTDIAPTLEQLKQLSYLDLVIKETLRIAGPIDRIVPRVVSEDIVVGGAFIPKGTSANIDLYAIHHNTNIWKNPDQFIPERFAEGGEQESHEGLTWVPFGNGARQCIGMNFSLAEQRIVLALMVRKYIIDIPKDSIHYDHVVFDSTETKAPESLKLKFTKRH
>CYP509C11 P450-20a Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
62% to P450-12, in the CYP56 clan 35% to 509B1
RO3G_06942.1 revised
MEIVESVFKLYHIALENLLPILHKKHKKSYIGAAISLVFLQRVYSYFRAPKHLRHMPIIPYFSMVKSLLNHELAYSRFKRLILPAIGENNGIYVSKVPLDWTVYIANPMIAKYVLFHTDTYPKSHDMLTKLGSDSPLVQLIGYDNILISNGHLWKNQRKLVNPAFHRSMPIKTVSSVIFDLFSAIEKENGTISIAPKMKDFTLDALGLTLFGFDFKALKGDPDEWTKVFRQGIQVAMDPFLNVLSPLYSVLSFIFPEKRRQMKAVIKLNGKMDQMIKQKHTEVLSGAYSDIPENEKDLVVLMLEAERRGEGITNDLQLRNNMALLLLAGHDTTATALSFCFYNIAKNKHVQQKLREEIIGVLGDEPVDIVPTLEQLKEMPYLNLVIQENLRLNEPLNYLIPRVAKKDMIVDDILIPKGTTINFDIYGIHHNPKYWRNPNQFIPERFAKGGEHETHEGLTWLPFGDGSRRCIGMNFSMFQQRLVLAMIIRKYEIDISKDANDHRHIAGFKTKSRGSPKLTFTKRY
>CYP509C12 P450-12 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
52% to P450-7_var1 in the CYP56 clan, 36% to
509B1
RO3G_05077.1
MMEIAEFALESYRSTLEKILPVLQKKSKKSYIGAAITLIVLHRIYSYFKVPKRFQHLPKLSYFPSAKSIFNNEPIYDRYKRLVFPVIKENNGIYVSKISFDWTVYIANPVAAKHVLLKADLYPKSHDFLKMLGSNSPVVQFLGYDSVGLTNGHVWKNQRKLMNPAFHRSMPINTMSTVIPDLFFVIEKEN
GTIAVPSVMRDFTLDVLGLTVF
GFDFKALKGDPDEWTKTFTLANEGLFDPILNIFGPFSFILTAIFPKRREQLKAVAKLNGKLEQLIHQKRMEIENGAYSNTPENEKDLVALMLEAEKRGEGLTNDLELRHNIAGFFLAGHDTTANALSFCFYNLAKNKHVQNKLRQEIISVLGDDPKDVVPTLDQLKEMPYLNLVLKENLRLNGPADNILPRVAAKDMVVDGTFIPKGATVNIDIYGIHHNPKFWNNPDDFIPERLDENGEQDSHDGLTWLPFGNGARQCLGMNFSLTEQRLLLVMMIRKYEIDVPKDSIHYERVIFGSETTPPNSLELTFKKRY
>CYP509C13P P450-22 pseudogene Rhizopus oryzae (Zygomycete
fungus, Mucoromycotina)
53% to CYP509C10
45% to CYP509C9 in the CYP56 clan
AACW02000137.1 (-) strand
52294
SKIPLNWTIFITNPMIAKYILLK
52226
KDRYSKSHDVLNMLSPNS 52122
FVRFMDLQNVAFAIEQNWKKQQKILN ()
NTVFNRSMPAKTISNVLSTLYSDIEKEDGTDHIIEAMKNVALDVLG
()
HSYHNFEFKALQENPDE*TKTYEFVNNVLFNPVLNFFNTLSRLLSIVSPTRRKTMAAIDK
FNGMARQNRV*LQNG &
SMFN*PDTEKHLLTLISEAEESGEGLLSNTELRIRVPSPPSFFLRK*YKLVNN*QN
LATFFFA (1)
GHETT (0)
QTLIEEIISTLNDKPVEVLSTFEQLK*MEYLDLVIMEI (0)
TLCLAGPFDTIVPIFATEDIVLSSNLIPKGT &
50948
RNNIDVYAHHNPDYWKDHDQFILERFLKGEECGSYGGLTWLPFGNGVRQCIGMNFSLPEWRIALTLMSK 50742
>CYP509C14 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
40% to CYP509C4 Rhizopus oryzae
fgeneshPB_pg.49__3
first amino acid is I = ATA instead of M = ATG
conserved location for M in CYP509C15 and
CYP509C16
IDTITNIFLSFETFVKNVVDYLPKGSYVVAA
MCLFFCKKVYDFTAVPYELKKFPNIPFFYFVKSILSVESVENRTKRLVLPLLHKNNGFYVSRFPFYWTVFTTDPDAVQYL
LMKGEIFPKDTRFTSAVSKDSLIIRLFGSSNVAFISGEPLKHQCRTMNPAFRRTAPVNIFGRLIPDMFRLIDKSDGDILI
VNLLQRMTFDALGKALFGFDFKTMKEDNSAWMTAYSDAMSGVTAPVLNIIPSLEYILRYFYPNYTKAKNGVDKLNRLILE
LVNKKKQELEESMPQSCSNNNNGDTDGDAYDQEKDLLTLILEAEMKDNKSSGSDDLRANMATFIMAGHETTASSVSFCIY
HMVINKDVRDKARREALDILGYDDFISPPTFDECKRVNYINMVVKEALRLCTPGGLLFERIATEDVFLSGVFIPKGTRIS
VDIEALHKNPAIWKNPSVFDPERFSKGGEHEQHRGITWAPFSDGNRKCLGINFSMTEQQVILLMLLKHYEWDLSENSIHN
NGMVYDNVFSFAPKTLSIKFHKRH*
>CYP509C15 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
67% to CYP509C14 Phycomyces blakesleeanus
e_gw1.3.167.1
MDIVNSISLSFGPSAKRLVDYLPKGSYVAAAVV
LFLCKKVYDFTTVPDKLSHFPSVSYFSFLRSTLAVESIEDRTRRFILPLLHKNNGFYV
(0)
SKFPFYWTVFVTEPLAVQYLLMKG (1)
EIFPKDSRF
MDALSKDSLAVRLFGNSNVVFSTGDLWKHQRKAMNPVFHRTVPVDLFGRMIPDIFKLIEKTDGNVLVDSFLQKITFDALG
RALFGFDFKTMGDDDSEWIAAYNDAMSGITAPILQVATSYERILRHFYPHYDKASKGIDKLNKLILDMVDEKKKKIEESK
GQPDAGHEKDFLTLILEAEMKENAISDPDDLRVSKTKCLSGHLSTASSIAFCIYHMAINKASLKDIQNKARREALDILGD
DDSMVPPTVAECKRVNYINMLVKEVLRLCSPFGAILERMTAEDVTLSGAFIPKGTLVSVDIEALHKNPAIWKNPTVFDPE
RFRKGGEYDQHKGITWAPFSDGNRKCLGVNFSMAEQQVVLLMLL
KHYEWDLPENSIHKNGIVYDSIFSFTPKSLSIKFHKRH*
>CYP509C16 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
67% to CYP509C14 Phycomyces blakesleeanus
fgeneshPB_pg.3__395 revised
MDTINHISPSFESYITVFAKIVPKGFYVVAAVALFLCKKVYDFTAAPYKLRHFPKVSFFAFSKSIFSAESVEHRTKRLIS
PLLHKYKGFYIAKFPLYWTVFVTEPHAVQYVLMKGEIFPKKTRFMNTLNKDSLMIRLFGSSNIAFASGEIWKHQRKIMNP
AFHRTAPIELFGRMIPDMFRLIDKSNGNIMLADLLHRITFDAMGKALF
(1)
GFDFKTAREENSEWTSAYNDAMSGI
SAPILNITPSLEHITRYLYPDYAKAKKGIDKLTELTLEMVNERKEKIQEAIGQPDDGREKDFLTLIIEAEMKEDKASGSG
GLRENLKAFLVAGHASTASSISFCIYHLAMNKDVQNKARKEALDILGDDANISTPTVNECKHITYINMIIKETLRLNAPF
GTLFERIATEDVTLSGVFIPKGTIISVDIETIHKNPAIWKSPTVFDPERFSKGGEHDQHEGITWAPFSDGNRKCLGINFS
MAEQQVILLMLLKHYEWDLSENSIHKNGIVYDGISLFTPRSLYIKFNKRH*
>CYP509C17 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
76% to CYP509C14
Phycomyces blakesleeanus
e_gw1.3.168.1
MDIINNISLSFKPFVKSLVDYLPKGSYVAVVVALFLCKKVYDYTTVPYELKHFPSI
PFFSFIKSVLSVESQEDRTKRLVFPLLHKKNGFYV (0)
SRFPLYWTVYTANPEAVQYILMKGEIFPKDTNFMNVLSRDSLTIRFFGSSNVAFISGEPWKHQRKTMNPAFRRTAPVDLFGRIVPD
MFRLIDKTDGNIFIFDLLQRVTFDALGKALFGFDFRATVEEDSAWRAAYIDTMAGVTAPILNIIPSLEYILRYFYPDYNK
ASKGVDKLNALILDMVNKKKKKLEESKDQPDGGQEKDLLTLILEAEMKENKSSESDDLRANMATFIMAGHETTASSVSHC
IYYMAMNKNVQNKARREALDILGDDSSTAPPTFDDCKRINYINMIVKEALRLSVTSGALMDRVATEDVTLAGEFIPKGTY
ISVDIEALHKNPTIWKNPTVFDPERFSKGGEHEQHRGITWAPFSDGNRKCLGVNFSMAEQQVLLLMLLKHYEWDLSENSI
HKNGIVYNSIFSFAPKTLSIKFHKRH*
>CYP509D1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
49% to CYP509B1 Rhizopus oryzae over the last 405 aa
region
fgeneshPB_pg.25__98
MLAKKVNGYAGFTLDAIQTIYFKYIFPTTGHQNRSSIIAYLTALILLYMAYSRAIKLVRPPKALSHIPHVPYFSYMSSLI
KKENTISRNKRFANKLFEDPESNGLYLRPNVKGWEVVVTRPEDAKKLLFKSDIFPKADFTSGIDGTILSKFSRGPNLLFT
TGAHWKAQRMVANPAFHRSAPVKLFGELTQKLFRVMDNRANKTVDITRLMEAWALDAIGLAGFDFDFNAIENPNSSWVRI
YERVDKALVHPFYSFFPKADKYLLWVLPNRKQAHTDLDIFLKMIDNVIIAKKKALHENKSNKHLENSEKDLLTLMLESEA
KGSTLSAKELRSNMCVFFAAGHETTANSLAYAIYFMAVNPDVQCKAREEAFKVLGDAQEDIMPTIEQTKSMDYINAVIKE
TLRSHSPALGTFARKATKDTELGGVLIPKDTMISMDIFNLHHNPNVWNNPDEFDPSRFLPGGEAEKQINNGFSWIPFGTG
ARQCIGMNFSLIEQRVMLSMMLRKFAWSLPEDSIHKDYLHTTNLVISSAKDLNINFEKLY
>CYP509E1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
43% to CYP509D1 Phycomyces
blakesleeanus
e_gw1.11.60.1
MANSSFENLQSLFVDFVQPQLVQRKKQAGVIFSAVVLVLCYNTINKIIYPPKSLRHIPHV
NYIAYTRSQLRKQPASEQARELLLPLLAENNGFYA (0)
IPFLGKWSVQVANPIAIKTILLKF (1)
DMFPKANSLSKSQGTLAHRFIGGPNVFLLEGKKWRKQRMISNPAFSRSMPVDMFGRITINLFKYLDNIDPTIDVLDTMKK
WTLDTLGSAVFDFDFESLTKPNNEWTSIYYEINASLFVPIFNILPVLEKSFLWMFPKRKRVHDKMTKLKDMMRQVIIQKQ
ARLKENKPNPNLKDTEKDLLTLLLESENEGHEPMSEDELMSNLCAFFFAGHDTTANALSSALYHLAVQQDVQKKAREEVI
NVLGDEPEDVIPSIEDTRQLDYLNLIIKENMRINPPVGGPLDRLVTEDIVLDGVLLPKGTSVKVAVYSLHRNPLLWDSPE
EFRPERFLPGGEADKIEGMGYIPFSDGGRQCIGMNFSLVEQRVLLAMMLRKYTWKLSENTINKDELQVYAFNIMAPFDLK
ITLEKRY*
>CYP509F1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
51% to CYP509D1 Phycomyces blakesleeanus
e_gw1.20.54.1
MSSYQLSGYTGLTLNQLQVLYSKYLVPTLKDKAKSTTIASAVALLLGYLAFKKIQEP
PHEIRHLPHISYFTMLRSILQGEPTSSLSKRLVIPIISCPENNGLYA (0)
RINGLGWTVHVASPEANKKMLMRTDIFPKSDPLPGTDGTLASRFLRGPNVLLLNGASWKTQRKLMNPAFHQSIPVNMFGG
LVQRLFSVMENETGPINVTNLMMRWTLDVIGQAGFDFDFHATDEPENEWVQVYNSISKGMGKPLWFFFPVLDRKFLWLFP
ERRKSHKSLDRFLEMLDGVIVKKRKALKENKRNPSMKDNEKDLLTLMLEGSQTGGAALTDRELQSNLCIFFFAGHDTTAN
ALSFIIYFFAKYPKIQQRAREEAHKILGDAPQDVIPTVEETKDMTYINMVIKETLRIKGPVTAIPARRAAEDTELEGVFI
PKGTLLTSDIYNMHHNPKIWNDPETFDPERFKAGGEADMLASSGMPWMPFGGGSRLCIGMNFSLAEQRVMISMLLRKYTW
RLPEDSIHKDELRTNNIGIMSAKILDIIFEKIY*
>CYP509F2 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
53% to CYP509F1, 53% to CYP509F3
e_gw1.20.55.1
MSISSLTAHTNYALDIIQNFCTNQDVQNLVKGNLPYISLAIVTTLAYITYEKVCRPPPS
LRHIPSIPYFKFMRSMLKGDTAAIHSKQVAIPLLSGKNHNGFFV
(0)
RPNIRGWEVFVANPEAVKQIFNNIDIFPKSEPLSDSDGTLFGGFIAGPNLAFLSGAAWKTQRKLINPAFRQSMPVNFFALSTQRL
IQVVDKSNDQVNVTELMGRLTLDVIGKTGFGFDFHAIDNPGNEWVRIYNNITRGLYRPLWFLVPILERKFLWMFPERQKV
HQDLNKFLSMLDIIIDKKHKDMKEMKDLQLENNEKDILTLMIEGAAEGNGILSYKELQSNICVFFLAGHETTSNVLSFVL
YYLAVNPELQHKARDEALRILGDDPKEIFPTVEQTKHMEYITMVIKETLRLRPPAPSVLTRTCAADTVVAGVFIPKGAFI
APDIYDLHHNPDIWENPETFNPERFRSGGEADILTNNGMPWAPFGGGTRLCIGMNFSLTQQRVVLSMLLRKYTWTLPEDS
IYKDDLHTNAIGTLTAKKLEISFRKRY*
>CYP509F3 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
54% to CYP509F1 Phycomyces blakesleeanus
fgeneshPB_pg.20__100
MISNQVSECAKFTLGYIKDIYIKYFLPTFLTNKRGPAIASAAAIVLLYMAYDKLFSPPRAIRHIPYIPYFSFLKSLLQST
SIAEHNEAFVFPIINQKNTNGIFSHPGIFGWEVAVANPAAIKKIMLKIDAFPKADVIRTTEHTIISRFLRGPNLVFSNGS
SWKTQRKIANPAFHRSLPVKLFGDMAKKMFQVMDKQDSLVDITDLMERWTLDVIGEAGFGFRFNAVEDPTNNWVQLYKNI
SNGVNDPFWFFFTNLETNFLWLFPKRQRTHRELDTFLEMLDDVIVKKRADIASNNKNPHLQENEKDLLTLLIEASKEGSG
SLSDQELMSNLCAFFVAGHDTTANALSFTIYYLAKNPDIQQKAREEAISILGEDQDTIPTIEQTKEIDYINMVIKETLRM
NSPAVSAITRISTEDTELDGVFIPKGALVVPDIYALHHNPTIWHNPEEFNPERFVPGGEAERLSGAGMCWIPFGSGARQC
IGMNFSLAEQRVMLSLMLRKYTWSLPEDSIHKNMLQATKIGVMVAHDLNIVFKRRY*
>CYP509F4P Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
54% to CYP509F3 Phycomyces blakesleeanus
fgeneshPB_pg.20__103
SNV*IFFVATHDTTENAQSLAIYYLARNLEIQHRERKNVINISGEDKQDIIPSVDQTKGIIYIKMPIKATLGI
KEPILATLTQISLGVTVTVNLEIVL
>CYP510A1
AB045779 Lentinula edodes
MYTTISPMLVVSLATLAFISLFNIYRYRYRPSTVNSPYPPGPKI
ATMPTRDAWVEYREWGNNYGGLVYLPERNTLIANKSEIAIELLEKRARIYSDRAMTPI
IKLCGGEDILSLERYSEKWRIDRRVFQQTFRQAASSRFYPAQYNKIHEFLRQLLMTPD
KFMQHTMKLSQALVYKGLYGLDVDSEDPLAKKAVEVMDTLGQALLPGSFPAYERFPFL
RFMPSWFPGCRFKRIAIQCSQGVKEVDTIPFDIAMAHLESGTGTSPIAELAIRKPQDI
KAIKAMGTISYLASADTTMSSISSFLLTMCQNPDIQAKGRDEIERVIGTDRLPTFEDR
QSLPYVEAIYREVMRLHPALPLGLPHVSIEDDFYRGYHIPKGCVVIPNIWAMNRDPDV
YTEPDRFLPERYSESPTGPFESINNIYAFGFGRRVCAGRHMAENTIWLTIASVLATFT
LGKAKDGKGNEIDIPGEYTDQFFRHPKPYRSSIFPRSTLARELVLATNAE
>CYP510A2P Lentinula edodes (a basidyomycete fungi)
GenEMBL AB015310
PLLRAMNRNPNVYQDPDRFLPECHLKSAAGPFESIDNIYAYGFGR
VCAGRYMADNTIWLTVASVLAAFTMGKAKDGNG
RYPKPFQSSIIPRSQAAEILVLAT
>CYP510A3 Lentinula edodes (a basidiomycete fungi)
GenEMBL AB049963
MMYTAFFGLLAVATLALIGLVGIYRGRRQPYTAAGSCPPGPKVA
IMPTHDAWVEYKKWGNDYGDLIYLSERNTLITNKSEVAMDLLEKRARIYSDRAMTPIM
KLCGGEDILSLERYSEKWRKDRRVFQQTFRRAANSRFYSAQYNKIHTFLRQLLLTPDD
FMEHMLRLSQALVYKALYGLDVDPEDPLAKKAVEVIDTLGQALLPGAFPAYERFPFLR
FMPSWFPGCRFKRTAIQCGRSVKEVDTIPFDIAMAHLKSGTGVSPIAELAMRKPQDIK
AIKAMGTVSYLASADTTMSSISSFLLTMCQNPDIQAKGRDEIERVIGTDRLPTFEDRQ
SLPYVEAIYREVMRLHPALPLGLPHVSIEDDFYRGYHIPKGCVVIPNIWAMNRDPDVY
TEPDRFLPERYSESPTGPFESINNIYAFGFGRRVCAGRHMAENTIWLTIASVLATFTL
GKAKDGKGNEIDIPGEYTDQFFRHPKPYRSSIIPRSALARELVLATDAE
>CYP511A1 Botrytis cinerea AY277723
MGLLSDVINNFLPETPLAWAALILASFTLYSVQLVVRRLYFHPLSKIPGPFLARSTYWYEFYQDIILGGIYVKNYAALHE
KYGPVLRASPDRVHVSDPDFFHEVYSSGSKYMKDPAFFQAAGGIPEALPAIVDVEYHRRRRKLINDLFSAKSMEALSHLV
LKVVQNALSKAHEHHEANKVLDIQRLYTGITIDTIMQVLCDRTLNFIDAKEEEEPPFLATLRTFSENFFLLKHFPILIWM
ALNIPKSIAQKLIPGEFEFRASINQWIRDRASEHELGVEKAEDGRKTVIDLLLRPEDGGRPLTHQAVEDETYSFAFAGTH
TTSHTMSMGTYYLLSHPAKLQKLRDELKPIPKNDQGLYEYKTVRSLPYLNACIKESLRMSSPVPGILPRLVPAEGMTWRG
HYLPPGTSVSSSIYSVHTDPNIFPNPEQFIPERWLANENLDHYLVVFGKGSRACIGLNVAWMETYLTFSNFFTSLNMTLF
ETNEQSTDWTDCGNAMIKKHVRVKVDSLAS
>CYP511A2P Fusarium oxysporum
44% to CYP511A1 Botrytis cinerea, N-term, cannot find
whole seq
FOXG_05899
78% to CYP511A2P Fusarium verticillioides, probable ortholog of the pseudogene
WATTSTS*
NILYYTAVAFGVFGFYWLCLVFYRLFLHPLRNVPGPKVAAATSWYEFYQDVILDGHYIKDYPRLHERY
(1)
GPIVRMSPNRVHINDPNFYHK (2)
VYSTGNKFFKEPAMFRFARELDALPFIMDPAARKVRR
GIVNPMFSPRAIKDFSPLALQIIKGALKKIGDSYETGKPVSLKRLESNFA
(0)
>CYP511A2P Fusarium verticillioides
78% to CYP511A2P Fusarium oxysporum
FVEG_03770, probable ortholog to CYP511A2P Fusarium
oxysporum
WSPTSTSW
NIISCTTLAFGAFAFYWLCLVFYRLFLHPLRNVPGPKIAAATSWYEFYQDVILDGHYIKD
YPKLHEIY (1)
GPIVQMSPNRVHINDPKLLPQ (0)
GVFYGTKFLREPAMFRFAGELDALPFIMDPAAHRVRR
(large deletion here about 140aa)
GRQTVFDAILDAEPDHSTKGLVDVAFSLVIGGTETTVTTITYGVWCILKNPNVEKKMLEELRTVETNSDGLVEYPNLMNLPYLTAVIHKT
LRISSPAPGILTRLVSSGGTKYGSHFLPADTSVSTAQRLIHYDPVLFPEPETFMPERWLDNSDKASKKNLIPFGKGPRMCVGLNLSYMQAYVFLGNLIRR
FDLSLQDKDQGILRWKDCIALHIEDDVLIKVNGLR*
>CYP512A1
AB057426 Coriolus versicolor
MEDPTVLYACLAIAVATFVVRWYRDPLRSIPTVGGSDLPILSYI
GALRWTRRGREILQEGYDGYRGSTFKIAMLDRWIVIANGPKLADEVRRRPDEELNFMD
GLGAFVQTKYTLGEAIHNDPYHVDIIREKLTRGLPAVLPDVIEELTLAVRQYIPTEGD
EWVSVNCSKAARDIVARASNRVFVGLPACRNQGYLDLAIDFTLSVVKDRAIINMFPEL
LKPIVGRVVGNATRNVRRAVPFVAPLVEERRRLMEEYGEDWSEKPNDMLQWIMDEAAS
RDSSVKAIAERLLMVNFAAIHTSSNTITHALYHLAEMPETLQPLREEIEPLVKEEGWT
KAAMGKMWWLDSFLRESQRYNGINIVSLTRMADKDITLSDGTFLPKGTLVAVPAYSTH
RDDAVYADALVFDPFRFSRMRAREGEGTKHQFVNTSVEYVPFGHGKHACPGRFFAANE
LKAMLAYIVLNYDVKLPGDGKRPLNMYWGPTVLPAPAGQVLFRKRQVSL
>CYP512B1 pc.30.92.1(genewise2nd.30.46.1)
Phanerochaete chrysosporium
MSLHQVYDAVVAHGDMGTLLVYMAYSVPLVMFLYSLFSPASLRHIPTEGGPSFPLLSYKAARAYLRDATGILQRGYDKHKGKPFKVAMPDRWVVVLTGKKLVDELQRLPDDAVSFIKGASDLSGTEHMFGRQVIDDPFHVPIIRTHLTKNLAPMFSDVFDEVSIAFQELIPACDGEWVPVHAIKVARSVVARTSNRIFAGLPICRHPEYLNLVINFTVDVAKGRYALLLFPPALKGIAAKILTNIDGRIKEGLKYLGPLIEQRMALAEKFGNDSSEKPDDMLQWIIDEVRARNQSVFEVVRTVLLVNFAAIHTSSNSFTHALYHLAANPEFIAPLREEIETIVSEEGWSKAAIGKMWKLDSFMRESQRYNGINSVSVKRKALKPLTLSDGTFIPKGTVLVTPTVATHFDDDNYKNPTVFDPFRYYREKEQDMSAVKHQFVTTSPDYVSFGHGKHACPGRFFAANELKAMMAYVVVNYDVKFEKEGVRPENIYAAMGISPDPNARVLFRKRESIVSV
>CYP512B2 pc.30.93.1
Phanerochaete chrysosporium
MTPSHSFPDLVASCISAWTLCFALGFSIAAASFYSLFGPFNLHHIPTVGGSSIPLISHRGARKYMRDAKGVLQDGYKHKGKAFKVALTDRWLVVITGKRLVDELQKMPEDVASFVGAVADFQGLRYIFGQKVLDDPFHVNIIRSHLTKHLSSVFGDICDEIYVAFSELIPQQDEEWVPVHAIQVVRTIVARASNRVFVGLPVCRNAGYLSLAVNFIVDVAKARDFIALFPPVLKPLAAKMTSDIGTRVQEGMQYLEPLINERLRLMEKFGKDWTDKPNDTLQWMMDGIMERDGTIEQLVRIVLLENFSSIHSSSNTFTHALYHLAANPEYITPLREEVETAISEEGWTKAAMSRLRKVDSFLRESLRLNGINPVSMQRKALISFTFSDGTYIPKGTILVTPALATHHDEDNYEDATTFKPFRFVGENPEDDVPLVTTSADFVPFGHGRQACPGRFFAAHQMKAMMAYLVLNYDVKFENEGVRPQNVHGVLSVQPDPKARVLCRRRKSSYT
>CYP512B3 pc.30.113.1
Phanerochaete chrysosporium
MASNHLFSGVLPLDRAASTLGYLVCGALLALLLQNILTTISLRHIPTVGTSTLPLLSYKGAYDFTRDIKGVFQQGYAKYKGRAFKIAFTDRWFVVLTGRKLLEELHRLPDSTTSFNHASGSITGSTYIYGRGWLSDPWHIPIIRDRLTKHLAASFGDMYDELETAFRELMPSCEEEWVPVHFITMARTVVARTSNRVFVGLPACRNLGYHTLLVNFALDVSKARNRLAWLPPALKRVAARALTRIDSRIEEGMQYLGPTIRARIVEMERYKGDWPDKPNDILQWIMEELIARKMPMEEAVRIILRINSSAVQTTANSLTHAIYHLAANPDLIAPLREEVDAVITDEGWTKLAMSKLSRLDSFMRESLRLNIVNPLSVRRMALKSFTFSDGTFIPKGTLMVTPAHATHLDEANYEHASVFDPWRFVHQKEEDLSPTKHQFITTSPEFVAWGHGKHACPGRFFASNELKAMMAYIILNYDVKFARAGVRPDNVYSGLTVAPNQEANVLFRRRQTQ
>CYP512B4 pc.30.114.1
Phanerochaete chrysosporium
MAFSDVVATVGAGPWVAYMMCAVLLALLLYSLFSPASLRHIPTEGGSSLPLVSYLGAYNVLRNLQSVLQRGYDKHKGKAFKIALPDRWVVVLTGKTLVDELQRMPEESASFIDATTELTGFGYIWGPRMRKDPCHVPIIRNQLTRQLSSAFGDIYEEIELSFQGLMPACEKDWTPVHVIEVARDVVARASNRVFVGLRVCRNPDYLDMLVDCAVSVASARNTLMLFPFVLKTFAAKNVVNMDRRIRRGMQHLGPIIEERMSLLRSLGNDWPDKPDDMLQWIIDEVAARQMPKEDVVRNIMFLNFAAIHTSSNSFTHAIYHLAANPDYLGPLREEVEAVTAKEGWSKTAMGRMWRIDSFLRESQRVNSINPLTVIRRTRTSLTLSDGTFIPEGTVVAAPAYPTHFDDENYVGGDTFDPWRYVREKEQDLSPSKHQYVTLSPEYVPFGLGKRACPGRFFAANELKAMLAYLVVNYDVKFEKEGVRPENMHVGLTISPDPAAKVLFRKRRS
>CYP512B5 pc.30.118.1
Phanerochaete chrysosporium
MARSDILDALSLGRTELSTTYLVFGLFLALFLYSLFSPASLRHIPTVGSSSLPLLSYKGAYDFLRDGRSLLQRGYNQYKGKVFKVAFTDRWLAVVTGRKLVEEVQRLSDDVISFPDASGEVTGFKYIFTKCALSRDPFHVNMIQRQLTKHMSVAFDDLHDEFETAFKELLPHNETAWVPVHAIEVARKVVARASNRIFVGLPVCRDKAFLDLMVNFTLDVARARDLLALFPPALKPFVAKLVVKLDSRIEEGMQVLRPIIQERMEIIEKFGKDSPEKPDDMLQWIIDALVERNEPMEQVVLITLFVNIAAINTSSNSFTHALYHLAARPEWIAPLREEAEAVIGNEGWTKNAMGKLVKIDSFMRESQRYNSIVPLTCMRKALQPFTLSDGTHIPRGTILVTPAIATHFDDEHYADAASFDPSRYVPVADAKQGGAPKQYVTTTAEYVPFGHGKYACPGRFFAGTELKAMMAYLVLNYDVKFAQEGVRPPNAATTLSTRPHQEARVLFRKRNSSVQ
>CYP512C1 pc.30.76.1
Phanerochaete chrysosporium
MSSMNAPALPATHIVAGAILVWLLVRTFGTQNLRHIPTEGGPSLPIISFLGLHAFLTRSREILEDGYQTHKGRAFKVALIDRWLVVLSGKKLVEELQKMPDDTVESATTEMFNMQHVFASNWHKDPVHSSLLRSLTRNLGVVFSDMFDELDTAFRECVPANAERWLPVQAHTTMASIVTRAANRIFVGLPVCRDAGYIHMMIHVAEDVSDAVRTLSMLPTFMKPFVARRATVIDQRIQQCLDYLRPAIADRMSMLERFGKDWEEKPNDVLQWIIDEVTARNQGEDEVARIVLFINFGAIETTSFAVTHALYDIVSRPGLADVLREEVEAAVATEGWTKAATNKMRKLDSVLRESQRLNGPTTASMFRRVLQPVTLSDGTYLPAGTTVVTPTLATHFDDTNYADAQTFDPLRFYKPDGVQAQLVTTSADFVTFGHGKHACPGRFFAANELKAMMAYILMHYDIRPEREGVRPENVYRGLNVLPDANARVFFRRRQTD
>CYP512C2 pc.30.77.1
Phanerochaete chrysosporium
MVLTTDFGGISTTHVVIGAFVTWLLLRYFSAKNLRHIPTVGGPSVPILSIVALYNFLANGKKVVLDGYQKYKGKAFKVALLDRWLVVLCNPKLVEELQKLPEALVGYSLLEAXGTIFETKHIFGADLLTDPVHLVLLRTLTRNLGQVFGDMYQEVETSFQELVPANEKEWLPVHASPIMRTIVTRAANRVFVGVPVCRDEGYLHLMVHFAEDVNKAFGLYTVVPSFAQGFVARKAKAVMDDCIERCLGYTRPTIKDRTTMMDSFGDNWADKPNDMIQWTIEETKARGQGEYDMARMLMFINSGAVETTSQAVIHALYDISVRPELADELREEVERAIAEDGWTKDATNKMRKLDSFLRESQRINGPMIVSMFRLVREPVTLSDGTFLPAGTTIASPTLGAHFDDSIYPNASTFDPLRFYKAEAAGQPQFVTTSPEYLTFGHGKHACPGRFFAVNELKAILAYMLMHYDIKPEQDGVRPENKSMGLGVLPNPDAKVMFRKRHAG
>CYP512C3P
gx.30.36.1 60% TO 512C1 PSEUDOGENE
Phanerochaete chrysosporium
NDLLQWIMDEAVARDKS (FRAMESHIFT)
QEEIARMVLFLN (FRAMESHIFT)
FGAIQTTSCV (1)
LSMFPNILTPVTLSDGTFLPAGTTVVTPVLATHYNEDNYTNAALFDPFSCKDNRSGGQQFVRTSADCVTLGHGRML
(1)
CPGRFFAAAELKTLVAYVLVNYDLRPETEGVRPVNIYKGLT
V*PSETAKVLFKKRQTDE*
>CYP512D1 pc.27.9.1
Phanerochaete chrysosporium
MQSSVGEVFASAPTLAKLLAGAAFVLFLNSLWNIWKLRHIPTVGGPAIPILCYIGTFRYLQDPQKILQEGYEKYKAKPGMFKIAAPDRWLVVVGHPNLIDELQKHSDEQVSFMDAATEFVGTRYALPGTIADDPWHIPPLKQHLTHAIGSFFGDMLEELRVSIEERIPSNEKDDEWVAIPALDTFFWVFTRVIDRIIVGLPIRDTEFIKLMVEFTMSIGIARFFIGLVPPMLKPAMAKLAARGVHKATAEAEKMLAPVIADRVRHLDEFGEKWADKPNDLLQINIEEARAQGRPLDEIVIRTIVSIFVGVSTSAASFVHVLYHLAADPELQAALRTEVEGAIARDGWTKAALVGMHRVDSVLRESQRVNGINSVSVMRTALQDITLTSAGAPVCLPAGTLCVAPERALHADKEHYPDPDAFVPFRFAELRATADARGGAQHQFVSTSTRYVPFGHGKHACPGRFFAGNEMKAAVAHLVSNYDVRLPDGASTRPPNELFGLAIVPNRSAKVMSRRRQPVV
>CYP512E1 pc.154.15.1
Phanerochaete chrysosporium
MSDYSSLLAYIFISLATLAYLKRLLWPDRQQLEHIPAIGPTAPILSYWGAFRWLSHGTEITQKGYAKYKGRPFKVANFNRWLVVVSGPKLIDDIRKAAEHELSFEEAAHENLEVRYTAGPCIAENSYHVPIVRGQLTRNLPFLFNDVRDEVAKAFGDHIPPTDDWTPVAAHPVIMQIVARATNRVFVGAPKCRDPDWLDLSIQFTADLILGAHIITQFPQFLKPLAARFFTRVPAAIRRGRRHLERTIEHRKACLEQYGADWPDKPNDLISWLLDEAKGEERTIHNLVTRVLTLEFAAIHTTSNSFVHALYQLAAHPEWAEPLRDEIEQVVKREGWSKSSLDKMHRLDSFLKESQRYYALGGVTMDRRAMKDFTFSDGTVIPEGTFVGVAVLATQHDPQYYDDPDTFNPWRFSDLREESDESGRHLLVSTGIEYFPFGHGRHACPGRFFAAIELKLMLAHIVMNYDVKAELDGVVPPILEFGQNLAPNMKAKVLFKNRQRS
>CYP512F1 pc.15.28.1
Phanerochaete chrysosporium
MISIDSISLISGLISFAFIAYYLRQDKLQHIPSPGPTGPISSWYAAYKYIRGDAPQIIEEGYRKYKGRIFRIADLNRWTVVVTSPSLVEELRKAPEDVLSFHEGIRYSLQLDYTFGREAVEHEYHIPVIRTQLTRHLTPLFADIHDEIVQSFTDLVPPSDTWTSVRVVPTVMQVVSRTSNRVFVGLPYCRDPAFCALAVRFATDVVKTGVALHLTPRALKPLGVRLVSPVSKRVEEGKGDHRQAGGRPAPRQPGGRPARAAQGACGNWPDKPEDMIQWLIEEANEDERTVEGLVLRILIVNFAAIHTSSMSFTHAVNMLAAHPECIAPLREEIEEVVREEGWTKAAVQRMRKLDSFMKECQRLHGLGAVTMSRVALQDYTFSDGTRIPRGTLVMAASRPIHHDAALYVPDADAFDPWRFARLRAADADASIKHQMVHTSAEYLAFGHGKHACPGRFFAVNELKLMMAHVLHTYDIRPQTSVPPGRWIRHSLLANPIATVDLKKRQT
>CYP512G1 pc.16.37.1 Phanerochaete chrysosporium
SVPTMGPTAPLLSYWGVLRYMTRPRDVLREGHVKFGGRPFRVASPLRWQYIVSSPELIDELRRAPDAELDPLAAADDILHFVKALGTKFASNTYHVPIVRTTLTKNIGTLLPSVLDEMRVAFARYIPADKEWHPVVAHDTNVRIVTQTSSRIFVGLPLCRDPELLKITMSYTPTVMKTGLLLKVLPRPLQSFVQRGSGSIDALIDRAHRLLLPTIEERRRMMDKYGAEWLDKPNDMLQWLMDSAEGEERTPRGLAARMLAVYFAATDTAALGFTVALYRLATHPEYVQPLREEVEAVIAQDGWTREAFRKMPKVDSFLKECMRLQGPSTLLLQRKAMQDFTFSDGTFVPKGSHVATSIVATHCDSAYYSDPLTFNPWRFVGAEDDAQDSKHRFATTSPEYLLFGYGRHACAGRFFAEIQLEMMMAYVVTTYDVRMEKPGVLPEPIEFGSMSLPSMTAKVCFRKRATE
>CYP512G2 pc.15.22.1 (genewise2nd.15.10.1) Phanerochaete chrysosporium
MFADSPTSLYALVLLGTVVYLLNWLKGSKYKSVPALGPTAPLLSYWGAIRFFLDAQGMLQEGQLKYGGSPFRIATRRYWQYIVSSPKLIDELRRAPDDELSFLDAVNEALELEYTMGAATANNLYHVPVIRNTLTRNLGNLSSEIYDEISNAFADCIPARDEWMAVPALQSIMQIVARTSSRIFVGLPLCRNREFLEISMTYTTDVVKTGLLLNMVPGPLKPIVNRLFSKVEQHIDRTHALLRPIIEERQRMMEQYGDDWPDKPNDMLQWLMDAAEGQEREPRALALRILIVGFAAIHTSSMSFTQALYYLAAHPEYMQPMRDEVEAVLAAEGGWSKGALQKMRKVDSFLKECQRYEGLGMLFLTRKAVKDFTFSDGTFIPKGSYVSTSRAATHGQSEYYRDPYVFDPWRFANLRDETGEGVKHQMVNTSIEYLPFGLGKHACPGRFFAANELKSMMAHLVVTYDVALDMPGEVPRSVHFGPINSPNRTAKVLFRKRRG
>CYP512H1 pc.21.108.1 Phanerochaete chrysosporium
LQDIPTVGGPNLPFFSYFGAIHFLVRANKIISDGYSKYKGGSFKIAQVNRWLVFVTDPALNEELRKAPEDQMSSPAALHQYVQGLYTMGFGLDGMLYYIEVLRDQLLRHVNPSPAMLYDEMQASFQDFIPQNTEWTPIPALSTSLKLFLRMSNRAFVGTPLCSNSEYLDLVTEFMNNVFKGAFFYNCLPAFVRPILARWLDLVNPCLDRAVRLLTPIYATRVAELEAAGKAEWAGASDDLLSCLVASHYSAARDVRELARILLVVNLAAVHTVSQSFTSVLFLLASRPAWQAELRAEAAAALAHGYTRDALARLRKLDSFVQESLRFNGLGALASTKLALTDFALSNGTVIPKGTLVSAPLRALHLDDEVYPDGASFQPWRFVRAGGEAAPRQSLASTSPTYLPFGHGKSACPGRFFAALELKMVTAYLVLNYDLKLEGDATEVPPVSWFITARVPNYKANVLVRRRQEKA
>CYP512J1 pc.37.85.1 Phanerochaete chrysosporium
NIPTLGTEMPVLSLWGALRYVMNSHNVIQEGYLKYKGRPFKIAQFDRWLVVLTTPHHIEELRKAPETGLSSRDAVDSLLKAKYTLGMDVDTVQRYLDLFREKLANKLGGLTSEVHEEMELTLNESLPKSEDWEEFCVLPSILKILFRTTNRAFVGAPLCRSEEYVALGEEYTTNVFKGAVIYNALPKALLPLLSKVLDFIGPTSRRCEQLFRPEMDKRAAYLEEHGADARGKYDDLLTWLIATHGAGDEINYSELTRIVLIANLAAVHSTAMVFTFAIFHAAADPGVADALRAEVASVVAEHGWTPTALTKMQRLDSFVREVQRMHTLGAALVMKIARTDYAFADGHVVPRGALVTAPATTVHRDDEHYPDAHTFRPWRFVGTPDESEADSARRKATSTSPTFLAWGHGKHSCPGRFFAVRELKMLLGSVLLRYDVRLKTPGVLPQDQWYLTFRVPDPTACVLLKRRTTA
>CYP513-525 #
are Dicty sequences
no sequence
>CYP526A1
AF330109 Fusarium sporotrichioides TRI13 gene
MFLSLCLMVLALYLLYKWALPKPISSIPYNPPALQSLFGDIPAM
IQGTKANNQTHMDWIIQQMKNHESPIIQLFLSPLQRPTVILADFRETQDIMLRRKDFD
RSTNIRGLLEDVIPDHHIYEQTNSVFRTHRKLVQDVMLPSFIQKVAGPAFHSNIMRLV
RVWDLKAQIADGSPFLATQDIQGAVLDAVYSFAFGSYYKSSTTLPKIEKLEKWNGNAE
NSSRNAPQSDKPFDFPDVAFDDLINATIDLAKAPQGLQGSPIAKLQAKVTMNMPHFRR
VRKIRDDFLRGSLKSAVSKLPSEGGKSDSQAVTSAVEQMVLRETALAQTENRSPNYFS
TMMQGELFGLILGGFDTTSTTTLWGLKFLTDNASVQKRLRQALQSSFTKAKAENRSPT
FQELAVARIPYLEAVIEEILRCAGATPALQRLAKVDTQILGYHIPKGTDVLFLTHGPS
VWTPGFEIDESRRSQTCQAAGEKKDQCWESHDISKFKPERWLGQKLPSNNREKDTDAT
ETAEEFDGLAGPTLAFGLGTRGCFGRRLGYQQLKTSITILIWNFELLPCPQELSSYRT
IEGLTSMPEHSYISLAKVDLTTT
>CYP526A2 Gibberella zeae strain HKM136 (same
species as Fusarium graminearum)
GenEMBL AY057841.1
cytochrome P450 (TRI13)
82% to 526A1
note: this sequence not found in Fusarium graminearum genome assembly
809 MFLSIGLVAVALYLLYRWALPKPISSIPYNPLALQSLFGDIPAMMKWTNASKQSHMEWII 988
989
QQMKNHESPIIQLFLKPLGNPVVILADFRETQDIMLRRKEFDRATNARALLEDVIPDHHL 1168
1169
YEQTNSIFRTHRKLVQDVMLPSFIQKVAGPCFHSNIMRLVRVWELKAEIANGSPFLATQD 1348
1349
IQGAVLDAVYTFAFGEYYKSSTTLPNIEILEKLNNSQNSKSDKPVDFPDVAFDD 1510
1511
LITATIDLAKAPQGVQSSPIAKVQSKVLMNMPYFRRVRKIRDDFLRGSLRSAVSKLQSEN 1690
1691
GLSDSPPVTSALEQMVLRETLLAKAENRSPNYLSTMMQGE (0) 1810
1873
LFGLILGGYDTTSTTTLWGLKFLTGNAGAQKRLRQALQSAFPKAKSENRSPTFQELAAAR 2052
2053
IPYLEAVIEESLRCGGATSALQRLAMVDTQILGHHIPKGTEILFLTHGPSVFTPGLEIDE 2232
2233
RKRSQTCQVAGEKKDSAWDDHDIGAFKPERWLRQKESSTGTDATEAAEEFDGLAGP 2400
2401
TLAFGLGTRGCFGRRLGHQQLRTSLAILIWNFELLPCPKELSSYRAIEGLTSMPEHSYIS 2580
2581
LAKVDLT 2601
>CYP526B1 N. crassa AABX01000480.1
cont3.625 NCU09636.1 (version3)
5049 MLSVVQQSIPFFDNIFNLAKPLLVLLTVTVTLYSLYRWLLPKPIPGIPYN
PQAAKSLLGDAPAMIKEVSATGEFRVWCAKQMRQMNSPICQIFIRPFSKP
WVLLADFREAKDILMRRKEFDKSSFLSDGMACMGSFHGIYMTGEKFKANR
QLIQDLMTTSFLNNHVGPAIFGKGLELMKLFETKMLLARGRPFSVKKDFE
YTSLDVMLEFAFGKNWVHTSLGPQMELVGKMQAEDIDAMMEGKDSDEPVV
FPLVPLVDFLNSVYEAPEIVEKTINALMPKLQTWWWSKQSWYKHIFDAKE
RAMKEQVEIAISNFQSGCIQTGIEHMLMREASRAEKECRAPDFRSKVLRDE
(0) 6101
6163
MFGNIVGGHHTTSGAMMWLTKYLTDHPVVQSNLRSVLYTTLSAAKNENR
LFTFEEIRHAKLPYLDAIIEEMLRINAVPVTREALTDTTILGYPIKKGTQ
VFFMSNGPGFLSPSFPIDESRRSETSRASKINATWDETQDLAAFVPERWL
VRKREGNGLLADDVDFDGAAGPQLVFGLGPRTCWGRRLAYMEMRIVISML
VWNFELLKTPPALSSYAGLEGIARVPQQCHVRLRKL*
6870
>CYP526C1 Magnaporthe grisea MG01353.4 39% to 526B1, 39% to MG07551.4
AACU01000036 cont2.245
MALPIAVAAPVVDRLPILTILVGSGLLYLVYRWLMPKPIPGIPYSPEHTR
SIMGSLPSFLEFVKENQGRSKPWFPEQNVKLGSALVQIWETPFSRPSCVL
TDFQEAQDILMRRTKDFDRGMRDSIVFQGTGKYHHISQTSQSPI
FKANKA
LVKDLMSPRFLADVSAPEIHSKVQLLLRMWSKKTQLAKGKPFNARPDIIE
AALDMINAAAFAYDEDSCSVSRQIRHLDSPDVRIDEKRDGSVDFSRAPDT
EQAVVVHELGVYLGTQFVSPVPRLAHAFNYLTRPRLRRNLAKKEEIVFTE
IRRALKRIEAGESTTA
SALEHLLRREMESARKAGREPNFFTPSIRDEGWG
YIVAGHETSATAISWQVKLLADHPEVQTKLRAVLRAAYSDAAASNRLPTA
REITSTPIPYLDAFLEEALRVRGPVLMTGREAKRDAYVLGHLVPKGTFVF
MPSMGPTFHAPGIPIDDSVRSETSRTKSWGGSWDPEDVGSFRVERWLTRN
PETGEDEYDVQSGPILAFGLGPRSCFGKRLAYLEMRIVIALLVWSFEFQK
LPEHLSSYAAHDTITTGPTCCYVGLKELN*
>CYP526D1 Magnaporthe grisea MG07551.4 poor match 39% to MG01353.4
AACU01000913 cont2.1400
MPSIPSTHTLISGALPGYVGLAAAISVFILAVLYRLALPKPYPGIPHDKR
AARSIFGNLTEMLDYLAKNENRITLWFAEYQQRVGSPLTQYFPAPFSKPL
LLLTDFLETQDIQLRRTKEFGRGKSVANIFRYTTPEFHVALSEHDSRYKA
NKALVKDSMSPAYLNNLAAPCIYDCAMDLVNHWKFKIPLAGGRPFSAHDD
IFGTISDMILASLFAFNSGIRSTQQQLKYLESLGADVQTRDAEGQGIDFP
KLDHLPYFRAFEILAEHQSDQAKTPFKVLQHYYSMLTRPELRSCYGTIKQ
FIKTEIDKAIMRLEHDNTITCALDWMVTREQQAAAKEDRKPEYHKPAFYD
GISGYYAAGHETSATTSSWALKFLSSYAQVQDRLRTELRKSHAAACQEGR
NPTIEEITRTSVPYLNAVIDETLRHRSPLQPSAREALVDTVVLGHRVPKG
ATIMMPYLGQSLLTPAFPVPLHLRSETFPKEGGRKAWADEDIQEFIPERW
LRVDEEGREVYDAAAGPMSAFGFGPRQCFGKRLAYLQIQVVLTLLIWNLE
FQPVEGTLGSFETIELTAIQPKHTYVKLKLAQ*
>CYP526E1 Fusarium graminearum FG03860.1
AACM01000167 FGcontig1.167_scaffold2
MSSHLVDLYEQAPKSFILTLFLSIASTLYLVRRALLPKPIPGIPYNKNAI
NSIMGDMAEFRAAKNRREWWALQAVKHQSPLVQVFMKPFGLPWVFVADHF
EASDICMRRLKEFDRADITRQQFDGLTPGHQITLKTSDPQFKKNRELVRD
LMSSSFLQQATAPQIHHKFSTLMSLWDRKRDLSGGRPFDISHDIHNAAFD
IILGASFGVDSGQGQIGKELDELRSKTTTGGNDDAFEFERVPFYDEELGC
FDTLIESFNVSIRSPYPLFSHFLYRNLSPKMREANAMRAKLQDREIAKSI
ERREKGHPQRCALDNMMAREDAIAEKEGRKPDYRSQAILSELLGYLVAGH
ETTSGVLRWGMKYLTKDQRVQSILREAFRTGYADALKQSRVPTMDEILKA
HIPYLDAVIEEMLRHARVAPITLREAVEDTQILGHHIPKGTTIGFLGNGP
GVMMPSIPVDPNKRSEASQAHVNKMELFDESNISQFVPERWLTTQTNEKG
EEVTVFDHNNGPQQAFGLGPRACFGKKLAYMEIKAFFTFVFWEFKLEPVK
AELATDEEMVALTRAPKNVFVKLTKVECCG*
>CYP526E2 Nectria haematococca
fgenesh1_pg.scaffold_25000035
Necha1/scaffold_25:100712-102551
52%
to e_gw1.8.241.1, 60% to 526E1 F. gram.
This gene model seems correct
MLQNTIDLFRQAPPGLGLAVCAVFIGLFLILLRLARPKPIPGIPHNVEAANSIFGDLPEFRAATDRREWW
VTQIIKHQSPLVQVFIRPFGLPWVFVADHWEAVDIATRRLKEFDRADETIYAFEGVAPSHHITMRSSNPQ
FKKNKELVRDLMSVNFLQD (0)
VSSPEIYDKFSLLVDLWNSKARFSNGRPFDVGKDIHNAALDIVMAASFGLG
LEHSQVAKQIRELESASSPGGQDDVFEFKHVPIDDEIGAFTILADSIAVAVRSPLPRLGHFLYRNLSPMM
RRAAAGRDRLRNREIAKSVERRESEHPQRCALDNMLAREDVIAEKEGRKPNYYSQVILSE
(0)
LLGYLVGGHDTTSSALRWSCKYMTEDQRVQSLLRKALYEAYPEAAAENRVPTIAEITKNQHIAYLDAVIEECLRHARPGA
ITFRQAMVDTQILGVHIPKGTNVGLMACGPGILTPRIEVDYSKRSANSKASMEKIPAFDESNIREFLPER
WLRTQKTDSGEEETVFDPNSGPAQAFGLGPRSCFGKKLAYMELRIFFTMIFWEFKMNTVKPELRGHDESV
TLTRSPKYVYVSLEKTGPQQSV*
>CYP526E3 Fusarium oxysporum
68% to CYP526E1 Fusarium graminearum
FOXG_17165
Seq runs into a seq gap. One frameshift =
&
MLSRLIELSERAPKDFTLALGFSILSALYLLRRWLLPKPIPGIPYNENAVKSFMGDIPEFRD
APNRREWWAQQPARHQSPIVQVF
MRPFGAPWVFVADYFEASDICMRRLKEFDRSDVTWEQ
FNGVVPGHHITLKSSDPKFKKNKELIRDLMAPTFLQQ (0)
ASAPEIH
DKFGSLLKLWDRKLDLSGGRPFDIAQDIHNSALDIILGASFN
&
DSGDGQIGRQLEELKAK
PASGGPDDLFEFEDVSLSDEQGCFTTLADSVGLSMRSPLSTIHHFLYRNLSPKMR
>CYP526E3 Fusarium verticillioides
92% to CYP526E3 Fusarium oxysporum = ortholog
70% to CYP526E1 Fusarium
graminearum
FVEG_13054 revised
MLSRLIELSERAPKDFTLALGFSILGALYLLRRWLLPKPIPGIP
YNENAVKSFMGDIPEFRDAPNRREWWAQQPARHQSPIVQVF
MRPFGAPWVFVADYFESSDICMRRLKEFDRSDVTWEQFNGVVPGHHITLKSS
DPKFKKNKELIRDLMAPTFLQQASAPEIYDKFSVLLKLWDRKLDLSGG
RPFDIAQDIHNSALDIILGASFGIDSGDGQIGRQLEELKARNVSGGEDDL
FEFEDVSIDEEQSCFTTLADSVGLSMRSPLPTIHHFLYRNLSPKMR
RARA
GRDRLRDREIAKSIERRESGQPQRCALDNMLAREDAIAEKEGRKPNYRSQ
TIMSELMGYLVAGHETTSAVLRWGMKYLTANQRVQSLLREAIGNAHSQAT
KDNRIPTAEEILKAHIPYLDAVIEEMLRHSRVAPVTLRQATTDTQILGRF
IPKGTTVGFLGNGPGLVMPSIPVSPEKRSEAALAHMERTQLFDDEDLAQF
VPERWLTSNVNDKGEEETVFDPQKRPAQAFGLGPRGCFGKKLAYIEIKIF
ITLFFWVFKLEPIKPELATEDEMLALTRSPKNVYVKLAKV*
>CYP526F1 Fusarium graminearum FG10629.1
AACM01000446 FGcontig1.446_scaffold7
MALLTFDSIKYPVLAGGLLLVGFIYTIYRSILPRPLEGIPYNVAATKRIF
GDLPEVRAYGSLTDWLATQAVKHKSPIFQAFIRPISKPWVVVTDYYEASE
ICTRRFKEFDRGSASTSIFKGVVPGSQITLQSHNPQFKKNKELVRNLMTP
TFLSEVSAPEIYDKFSRLVELWNLKLDHADGKFFAASRDIHHAALDIIVC
ASFGIDTQDTQLVKEKDQLSIEPRSENDGEISFKEVPLREELGALTVLSE
SVAKVVRTPSPPLFHFLYRNLSSQMRNAIALTRKLQRREIENGIKRRENG
EAMKCALDEISVREEATAKKEGREPYYHSQAIASELMSYLIGGHETTSST
IRWGISYLNRDQRAQSELRKGLQEAYQQAKAEKRPPTLTEIIQTRVPYLD
AVIDETLRVSYTFGMTLREAVVDTQLLGAHIPKGTAIAFLSNGPGVLSPP
IQYDESRSSEWVRARKPKQPVDQEYAFPDFVPERWLKSVVNEAGKEEVVF
DSQAVPIQAFGQGPRGCFGKRLAYLEMKIFFTLIIWTFEFLTLPAHVATP
KEVSSLTRHPDRVFIKPRRVVL*
>CYP526F2 Nectria haematococca
e_gw1.8.241.1
Necha1/scaffold_8:592224-594069
58% to 526F1, INATGG missing in CYP526F1
AACM01000446 FGcontig1.446_scaffold7
This gene model seems correct
MSWPEVTSSLPLQLLVGSSVLVAVIYTFRDAFYPRPLDFIPYNAEAKERILGDLPAIKAVGSVTNWLATQ
PTKHQSPLFQAFVAPFGKPWVVVADHHEAADICMHRLKEFDRARVTISVFGGIIPGGQLTLKSSDPQFRR
NKELVKDLMTPSFLAE (0)
ISAPEIYDKFTRLLKLWECKAILSKGRPFGASREIHHAALDIIVCVAFGLDPDQ
TQLVRALEALDVDHESEINATGGPDDEFVFKEEPLAEELEAFTRMSDSVSMSIRSPSPRLFHFLYGNFSS
VMRNARRLATRLQQREIANGLERRRTGQAQRCAVDQILAREEAMAEKEGRKPDYYSQTITSE
(0)
LMTYLIGG
HETTSSALRWGISYLSSDQRVQARLREALDLAHPQARAEKRLPSLEEIIQARVPYLDAVVEEVLRHSRPL
AMCMREAQTDTQILGAHIPKGTTVVFLANGPSVFTPRIQFDESRQSEWATSRREKHPVNDEIDIGAFSPE
RWLRVEKHEDGTEETVFDANLFPIQAFGLGPRACFGRRLAYREMKIFFTLITWKFELLSLPDALAVPKEV
FSLTRNPKEVYVKLRSRIY*
>CYP526F3 Fusarium oxysporum
69% to CYP526F1
FOXG_04849
MSLLDALDSSSTRLLLGCLLLAGIAYTLYRSMLPRPLADIPYNVSATNRILGDLPDVKAFGSLTDWLATQAIKYQSPLFQ
AFIRPFGKPWVVVADHYEAAEICTHRVKEFDRGTSSTAVFNCVVPGAHITLTSSDPQFRKNKELVRNLMTPSFLSEVSAP
EIYDKFSRLVELWNMKTEHANSQFFSASKDVHNAALDIIVCAAFGLDTQHTQLVKEIQELTPDNNISSTKIDGEIAFEEL
PLNEELNALATVAESVAKIIKTPSPPLFHWMYRSFSATLKNAFALTKQLQEREIANGIKRRANGEAMKCALDEISVREEA
LAKKEGREPDYYSQVITSEMMSYLIGGHETTSSAVRWGLSYLSAEQRAQSELRNALQQAYPQAKSERRAPSLVEIIQTRV
PYLDAVVEEILRLSYPFGMTLREVQVDTQILGARVPKGTTVVFLSNGPSILSPPIDFDDSRSSEWVKSRKPKPLEKDYDY
SSFKPERWLKTAAGPDGKEDVSFDSQAFPIQAFGLGPRGCFGRRMSYLEMKIFFTLVVWTFELLPLPADVARPKPVSSLT
RNPDRVFIKPRKVVL*
>CYP526F3 Fusarium verticilloides
93% to CYP526F3 Fusarium oxysporum
no gene model
MSLLDALDSSSTRILLGCLLLAGIAYTLYRSMLPRPLADIPYNVSATNRILGDLPDVKAF
GSLTDWLATQAVQHQSPLFQAFIRPFGKPWVVVADHYEAAEICTHRVKEFDRGTSSTAIF
HCVVPRAHITLTSSDPQFRKNKELVRNLMTPSFLSE (0
VSAPEIYDKFSRLIELWGMKTEYANGQFFSASKDVHNAALDIIVCAAFGLDTQHTQLV
KEIQELTPDNDTTSSKTDGEVAFKELPLNEELNALATVAESVAKIIKTPSPPLFHWIYRT
FSAKLKNAFVLTKQLQDREIANGIKRRANGEAMKCALDEISVREEALAKKEGRAPDYYSQVITSE
(0)
LMTYLIGGHETTSSAVRWGLSYLSVEQRAQSELRNALQQAYPQAKLERRPPSLSE
ILQTRVPYLDAAIEEILRLSYPFGMTLREVQVDTQILGARVPKGTTVVFLSNGPSILSPP
IDFDDSRSSEWVKSRKPRPLEKDYDYSSFKPERWLKTASGLDGKEEVSFDSQAFPIQAFG
LGPRGCFGRRMSYLEMKIFFTLVIWTFELLPLPGDVAKPKPVSSLTRNPDRVFIKPRKVVL
>CYP526G1P Fusarium oxysporum
40% to CYP526F1, first exon is about 6000 bp
upstream and second intron boundary is defective. probable CYP526 pseudogene
FOXG_12987
MSWFELTAGALSIFLLLFCLYNLALPKPIPGIPYNKSATKRLLGDLPDLIEYQKHTEEQCRWFALQNQKFNSPVCQVFIRPI
(1)
RKPRVVVSDFREAHDVLSKRLKDFDRSDRAREAFAGIVPHQMLSYQTVDPKFKKHRELMRDLMSPKFLN*
(0)
VSAPEIYSKVYCLVKLWDEKCLYADGRPFDAKRDIQRATLDVVTTVSFGLDEENSATKRQLDD
MLSRSTAGLIFTEPEKKIVVFPVYPLTTELHATLTIVESATVGFSSPIPRWHYWSLSQFPYMKNAARVREEWTRREIDKA
VKAISRNVPENAWATGSALEFMVLREAAAAKKAQRPPRFHRRRMYDELFGFIIAGHDTTAATLSWGVRCIADDPQAHRKL
QSLLQNAFSTALAEHRQPTIDEITSASIPYLDAVIEETLRLSAVFPIVSREAMVDTMILGHAIPKGTSVFFTLNGPSLMK
PPIGIPENIWSESLQGTKSRYGEWRAEDVEQFIPERWIDVDDKGVETYNAMKGPFLMFGSGPRGCYGRRLAYLQLRIFWV
LLMWNFEFLPVDPELRTQDVVEHVGVEPRESYAE*
>CYP526G1 Fusarium verticilloides
78% to CYP526-un1 Fusarium oxysporum, 40% to 526E2
FVEG_11760
MSFILYLSSMSWIELSAGGLSIVLLLFCLYNLALPKPIPGIPYNKNATKRLLGDLPDLIEYQ
KKNGQQRKWFRLQNQKLNSAISQVFVRPFGKPRIVLTDFREMHDILGKRFKEFDRSDRAREA
FAGIIPHQMLSMQTVDPRFKKHRELMKDLMTPKFLHQVR (0)
NSAPEINRKVNTLVKLWHEKCVHANELPFDGKRDIQRATLDVITATSFGLDDENSATKRQLDDM
LARSNAGVKFTQPGKKVVDFPIHPLTKELDATLTIVESSAVGFSSPMPRWHYWILSQFPY
LKNAARIREEWTRREIDKAVAAIPKDGSENTLAMRSALEFMVLREAAAAQKAGRPPRFHR
RRIYDE (0)
LFGFIIAGHDTTAATLEWGVRYIADAPHAQAKLRSALQNAFSTALAEHRQPTIDEITSTS
IPYLDAVIEETLRHSVVLPIVSRVAMKDTTILGHAIPKGTFVFFILNGPSLMKPAIEVPE
TARSEASQGTKNRYGEWRADDIEKFLPERWIDVDDKGVETFNALKGPFMTFGSGPRGCYG
RRLAYLQLRIFWVLLIWNFEFLPIDPELRTQDVVEHVGVEPCQSYVRLRKVAL*
>CYP526H1 Aspergillus terreus
38% to CYP526A1, 13 of 17 top hits are CYP526
members. Three others are CYP5134 members.
ATEG_03457.1
MVITLPVRASQSPSQREIVWYILSCLFAWLLYKFSLLCLPTPFHDIPHNEGTTRTIFGDLASMLSEVSKSNDIFTWLLRQ
TQKANSPLYQVFIRPFGRPSILLSDYWEATDIVLHRSREFDRTPYTADVFSGVLPNHHIHMPTGPEWKAHRRLLQDLMTP
NFLNNTAAPAIYDRALELVDLWDAKARLAAGRPFFAAEDIHNTALDAVLSFSFGGAFPHSATRPQLELLSTLYMEAVHRN
DTPLDRPAEFPQASPPDCIKAILDITGAFEYTKSSIFPRLMWFLASKTPRVRHAVRTKDNFVLRELQGATHRLVWKDSDA
DHTWAQSAVDLIVDRERKYAEREGRSPNFFGSAIRDEVFGFVLAGHDTTSTTIAWGIKLLADNPDAQTNLRLALKNALLE
AAASNRLPLCSEVIRTSIPYLDATIEEILRCAPTVPAVDRVALNDTVLLGHSIPKGTSIFLMNKGASFFSPPHEIEDEKR
SPSARAAKNKGHHAWDPETLDIFLPERWLVASEEQASAVGTANVVFDPAAGPAMPFGGGPRGCWGRRLAYLEMRLIFALM
VWRFELLGCPKELSGYDAFDGLVHKPKDCFVRLKRIES*
>CYP527A1 N.
crassa AABX01000356.1 cont3.332 NCU05848.1 (version3)
4191
MLQELLSLAQGPYALPILAASLVAYLLVSITITYRRLSHFPGPFLASFSP
LFMLKVLFSGHHADGYSRLNQQYQSPLVRIGTTDLITDDPAIIRHMNGAR
SAWGRSNWYRAMTLDPRGGSLFDEPNTKTHDLFKARLSFGYSGRENPGLE
GDIDEVIGMLIQYIKSRYISDDERGVLKRMDLAKVTQFFTLDVITRIAYG
KEFGWLKTDKDQFEWTSTVIKAVPANSLIAELPLLQKIFLSKWFLQWFGP
KHSDANGMGRVMGMAREMVAKRFGEKAEDRKDMLGSFVRHGIEQQACEVE
VLFQILAGSDTTAVAIRSTFFHLATSKKAYVRLLEEIDRAVKEGEVSSPI
RAEEAKHLEYLQACVYEGLRMQAPFSGLCMKSPPKGGDFINGMFIPEGTR
VGHNFGGLIRRRDVFGEDADVFRPERWLNAEPAKRLEMQQTTEMVFGYGR
WACLGKPVALMELSKVFFE
(0) 2785
2725
FFRRFDLQLVEPKNPWHEFNVNMCFQSDLWVKITERFPEGEKV* 2594
>CYP527B1 N.
crassa AABX01000074.1 cont3.486 NCU08112.1 (version3)
26652
MASLGGFFDPSRLTTASPKAILITTFSLLIVYYITSSIIAWYRLRHFDGP
WLGKFSYLWIFKIIHSGQMGEAAHAAQDKYGGVEPGYPSTVRIGPSDLIT
TELDLIRRMSGARSRYTRSDWYKLNRLDPYDDNMFSTTSTTYHDKLKSKM
APGYAGRDNTGVEKDIAHVISKLVDKIRTKYAAPKGSTSPAGREMLEFGQ
MAQYFTLDVICKTAFQVEFDHITKEEDVFGYIYMVHNLVYGNAMGATIPI
IGKVLSNPLFLKMFGPTTKDPRGMGLIMK (2) 27488
27541
VAREIVAKRFAPDAKDQQDML (0) 27603
27668
GSFIRRGLTQRQCETESIFQILAGSDTTATGIRSGLLYLCSNPRAYTRLQ
REIDERIASGLISSPCITNAESLAFPYLQAVIYESLRMRPPFDGLPFKIV
PPEGDYTRDGKFIPGGTKITATFGAMQRNKEVFGVDSDIWRPERWLEEEG
CDAERRREMKSVVEMVFGYGRWQCAGKMVAMLELNKIFCQ (0) 28237
28368
LMRNFDFQLANPTQPWKSRNYHIFFHDDFYLTVTDRHSKTEDEKSS* 28518
>CYP527C1
Magnaporthe grisea ESTs BM871448.2, BM863551.2, BU644850.2
MG07626.4 AACU01000923 cont2.1411
MMLQQVADALATHWLSGILAIATVYLATSYIIDYRRLR
AFPGPPLGSFSYLWLAYNALQGRQGSIFYEVMKRYRVPEHSFVRIGPNDLMTDSPEVVRHMS
SARSTYLRSSWYRTSKLDPSGDSLLSIMDTAHHDALKAKAGRGYAGRDNRNLESDIDDQL
RRLIGLLERKYLSGGGDASSFRPVDMATTMQYFTLDSITKLAYSSAFGFLDLDTDVYGYI
KAIRDAAPPIIVCSEWPLAGRIFFSPPFLKMFGPTPKDKSGVGKLMGTLRQVVASRFGPDA
KDQPDMLGSFVRNGLSQHQCEQEVILQIVAGSDTTATALRGTLLQLCSTPMVYLKLQKEI
DEAVRSGMVGEGVISQETARKLPYLQAVIYEGLRLNPPFTGALMKEVPPGGDEIDGVFIPAG
VRIGVSAKGIQMRQDVYGHDVDVFRPERWTECDEQRRMRMAANTELVFGYGRWMCAGKNVAFME
LNKVYFELLRRFDFQVVDTKTPVKEESFNVMVSKDMFMKVTKRVLYTGSILIRAR*
>CYP527D1
Botrytis cinerea =
Botryotinia fuckeliana
GenEMBL AJ609392.2
join(<935..1716,1765..1828,1878..2111,2195..2515,
2575..2703)
aba1 gene
43% to 527E1, 43% to 527A1, 41% to 527B1, 41% to 527C1
MSNSILNLGSFACLLSLGSIVLWYTISAVLAWYPLRKIPAPSFL
ATFSYLWLAKTTYSGKQYWIQRDLHKKYGPLVRIGPTDIITDDPEIIKKISSARSSHR
RGDWYLTGRFNPYYDNMFTMLEPGPHAKAKARTAAAYSGRDMPDLEVGVNAQLQTLIG
LMRSKYASNTVKPHQPLLDLGQVSCFFTMDVITRLAFGEEFGYLKEETDQYGFLGEVR
ELWPRMSTSADTPWIRKFLFSPPFLKVLGPKPTDKTGFGALMAVAEHHVGKRFAPDAK
KKEDMLGSFIRHGLNQQECEVEGLFMIVAGTESTASAIRSTLVHVMTCPRVYQKLKTE
INLAVEEGKVSSPIKLEEAKLLPFLQAVIYEGIRMRPPLLGLFPKIVPDGGEEFHGMF
IPAGTAICMNTSSLLRSTALFGDDAEVYRPERFMELEKSKRGEMERNVELAFGYGQYM
CVGKTVAFMELNKSIFEILRAFDLQLLSPAKPCDVLSYGIFLESNMLVKVTESEGTEYK
>CYP527D2 Aspergillus niger
e_gw1.21.29.1|Aspni1
59% to CYP527D1
MDFYKFATFIVCFFIGWYALTSVLAWYRLRKFPTPSWLAHFSYLWLGRLTYSGKQYWVHRELHRKYGPLVRIGPNEIMTD
DPDIIRSMSSTRSTFTRGEWYIAGRFNPHYDILFTVLGNDAHKKARSRVFEGYSGRETGIAVEHGMDRQVTRLIDLIRQK
YAVPGQDAPLLNIVDISSYFTMDVITELAFGQEFGYLQAEEDRYGFFHEVHSLWPQMSTVADVPWIRRIVFSKPFLKLLG
PRTTDSHGFGALMRVAHEHVQQKFSTLDNSKGDMMESFIRHGLTQEECEAEGLFTIIAGTESTAGTIRSILIHILSSPVV
YSKLKNEIHDAVQKGPISSPISNKEVRDLPYLQAVIQESIRMRPPLLGLFPKVVPAGGVEYHGQFIPGGTHICMNTSSLL
HSKSLFGNDPSVFRPERFMEASEDTCSERRKNLELAFGHGQNQCLGKTIAIMELSKVTFEMFRNFDFQTVSPWRVNHQVQ
SYGVFLESNMKFRVSQSE
>CYP527E1 Fusarium graminearum FG01767.1
AACM01000092 FGcontig1.92_scaffold1
MDLNSLSNYKTPGGAVVVLLAFVTFWWLTTTLIAWNRLKHIPGPWVAGFT
YAWAGWTEYSGKQHFSFLDLETKYGSLVRIGPELLATSDVEVVRRMSARK
STYRKSSWVDGVRLNPYHETMFGVRDPIEHDRIKTRLAPTYSGRDTPHLE
SVVDQQVNNLVSLIRRKYVSDPTSGDFRVMSLIKVASYLTLDVISKVGLG
TEFGCCASDSDPYGFTKAVAEHMPLMAMTSGVPWMRNVFCSPLFLKYFGP
KDTDTYGLGPLIKVTNDNVRARYSQEDGGKRDMLSSLKASGLPEGEAQAE
TLFLFIAGSDTTAAAIRVTMFYIISSPRVYQKLKKEIRKAIHEGRASSPI
TVAQARELPYLQAVIYEGLRIRPVTTGPQSKEVPPGGDTINGHFIPEGTS
IAINFPAIMGSKKLFGPDADVFRPERFTDLQDPDLAEMRRNVEMNFGNGR
WMCAGKPIAFMELHKVYFELLRAFDFQLVEPLKPMTSESYSLFRDHGLNV
RVTLAEDME*
>CYP527E2 Fusarium oxysporum
70% to CYP527E1
Fusarium graminearum
FOXG_13007 revised
MTLSYLSEFPTSSGIGIAVLCLLSSWWLGTTFIAWYRLRHVPGPWFAGLSYIWNGWIAYSGKQHHIFVALDEKYGSLVRI
GPEVLLTSDVELVKRMSATKSSYGKSSWVDGVRFNPYHETMFAVRDPRQHDRAKARVAPAYSGRDTPNLEGAVDQQINSL
ISLIRRKYLSEPASGAIRTLPLLNVLSYFTLDVISKVALGTEFGCCTSDSDPYRFYEGLDEHMPLMALTSDVPWIRAVMY
STTFLKYFGPRETDTHGIGPLMK (2)
VTNDNVRRRYSQQDQTEKTDML (0)
SSFKVHGLSEGNAQSETLFMFVAGSDTTAAAIRVTLFYLMSCPRVYR
KLKEEIRGAIREGRASSPITAAQARELPYLQAVIYEGLRMRPVTTGQQAKEVPAGGDTINGHFIPGGTSIAINFSAILGS
KALFGPDADVFRPERFIGLSASNLAEMRRNVEMNFGHGRWMC
AGKPLAFMELQKVYFELLRAFDFQLTEPLSPMRSESYA
LFRDFGLKVRATVAEDME*
>CYP527E2 Fusarium verticillioides
92% to CYP527E2 Fusarium
oxysporum = ortholog
FVEG_11734 revised
MDFSYISDLSSSSGIGIAAFCLLSSWGFITTFLAWYRPSHVPGPWFAGL
SYIWIGRTAYSGKQHHVFVALDEKYGSLVRIGPEVLLTSDVELVKRMSATK
SSYGKSSWVDGVRFNPYHETMFAVRDPRQHDRAKARLAPAYSGRDTPNLE
GAVDQQVNNLISLIRRRYLSEPAAGVFRTLPLLNVLSYFTLDVISKVALG
TEFGCCTSDSDPYRFYEGLDEHMPLMALTSDVPWIRAIMYSTTFLKYFGP
RETDDHGIGPLMKVTNDNVRQRYSQDQTEKTDMLSSFKVHGLSEGNAQSE
TLFMFVAGSDTTASAIRMTLFYLMSSPRVYRKLKEEIRDAIRDGRASSPI
TAAQARELPYLQAVIYEGLRMRPVTTGQQAKEVPAGGDTINGYFIPGGTS
IAINFSAILGSKALFGPDADVFRPERFIGLSASDLAEMRRNVEMNFGHGRWMC
AGKPLAFMELQKVYFE (0)
LLRAFDFQLTEPLSPMRSESYALFRDFGLKVRATAAEDMEQLSE*
>CYP527F1 Fusarium oxysporum
51% to CYP527E1 Fusarium graminearum
FOXG_09111
MASPFFERGLTWLPYFIVALFTWLLLSSAISWYRLRHIPGPFFGKLSYLWVAYITITGTQHDHLVN
LNRSYGPIVRVGPNEVLVDDPDLIRKVSSTRNTYTKGNWYLGGKFNPYHDP
MFQITDPAQHDRVKAKLSPAYSGRDAPNLEAVVNRQIGSLIQLIKEKYTSAQGDYRPMEGTRVTRLFALDVISNLSLGQE
FGYLKADSDFHGIVKALNEHMLV
MTLATDIPWLRNLIFSPMFLKLFGPTENDTKGIGPLMKVANTIVRERYAPEADEQHDMLA (0)
GSFKRHGLRLEECQAESLFMFVAGSETTATVIRVILLYIVASPHIYQ
RLRQEITEAISEGR
ASSPITDVESRQLSYLQ (0)
AVIYEGIRIRPATLGMFFKDVPAGGETMHGKYIPAGTSIGINASSLLRSE
ALFGPDPQVFRPERYLEVDKETSAQMKRDVEIVFGYGRWMCAGKPIAFMELNKVIFE
(0)
LLRVFDFQLVEPEVAMKSESYMVFHDQSLILRVTEADHK*
>CYP527F1 Fusarium verticillioides
89% to CYP527F1 Fusarium oxysporum = ortholog, one frameshift
FVEG_06713
MASPFLERGLVWLPYFIASLFTWLIVSSIVSWYRLRHIPGPFAGKFSYLWVAYITITGTQ
HDHLVNLNRRYGPIVRVGPNEVLVDDPDLVRRVSSTKNTYTKGNWYLGGKFNPYHDPMFQ
ITDPAQHDRLKSKLSPAYSGRDAPSLEAVVNRQVGNLIQLIKEKYISTQGDFRPM
&
EGTRVSHLFTLDVISNLSLGREFGYLKADSDFHGIVKALNEHILIMTLATDIPWLRNLIF
SPMFLKLFGPTENDTKGIGPLMKVANTIVRDRYAPEADDQRDML
(0)
GSFKRHGLRLEECQAESLFMFLAGSETTASVMRVILLYVIASPHIYQ
RLKQEMAEAISQGRASSPITDVDSRQLPYLQGVIYEGIRIR
PATTGMFFKDVPAGGETMHGKYIPPGTSIGINASALLRSEALFGPDPEVFRPERYLEVDKETSAQMKRDVEIVFGYGRWMCAGKPIAFMELNKVIFELLR
VFDFQLVEPGVAMKSESYMVFHDERLVLRVTETVHEQG
>CYP527F2 Fusarium oxysporum
52% to CYP527F1 Fusarium oxysporum
FOXG_15185
MLLEHFTANYWWAAALAIIAWYIVSSVISWYRLRHIPGPLLAKFSYLWLARLALSGKQYETHLELNKKYGPIVRVGPYEV
LTDDLELLRKVNGTKSLYAKGASYSGSRLNPWHESLFMMRDPIAHDKMKAKLIYGYSGKETMGPEAAIDEQIMNLVRLIQ
DKYISKPREFRPLLWSKTAGLFTLDVISRLALGQEFGCLNRDEDIYCFFDTLRDYLPIVSLTTDVPWLRNIAFSPLFLRL
FGPSIKDKKGIGKMMGLTNKVVEEFYHSDGEVRRDMLS
SFKKHGLTKDQCEIESIFMFVAGSDTTASVIRAGMLHILATPHVYCRLKREIANTIREG
RASKPISNADSLFQPYIQ (0)
AIVYECLRIRSVSTNMSFKEVPTGGDVYNGKFLPAGTNIGMNFSGLLRSETLFGKDAHIFRPERFTEVDDKTSAKLKRD
VELTFGLGRWSCLGKPIALMELNKIFFE (0)
LFRHFDFQLAEPHKAMQFDSYMLFRDKGLVLRVTESDLKDLKSIKEDIY*
>CYP527F2 Fusarium verticillioides
90% to CYP527F2 Fusarium oxysporum = ortholog
FVEG_12563
MLLEHFTSNHWYAAALAIFTWYILSSIIAWYRLRHIPGPFLAKFSYLW
LARLALSGKQYETHLELNKKYGPIVRVGPYEVFTDDLELLRKINSTKSSYAK
GASYSGSRLNPWHESLFMMRDPVAHDKLKAKLIYGYSGKETAGPEAAIDE
QIMNLIHLIQDKYISKPKEFRPLVWSKTAGLFTLDVISRLALGQEFGCLK
RDEDIHCFFDTLNDYLPVVALTTDVPWLRNIAFSPFFLQLFGPSIKDKKG
IGKMMGLTNKVVEEFYHGDGQVKRDMLSSFKKHGLTKDECEIEAIFMFVA
GSDTTASVIRAGMLYILATPHVYSRLKREIANTIREGRASRPISNAESLS
QPYIQAVVYECLRIRSVSTNMSFKEVPAGGEFYNGAFLPAGTNIGVNFSG
LLRSETLFGKDAHIFRPERFIEVDDKTSAKMKRDVELTFGLGRWSCLGKP
IALMELNKIFFELFRHFDFQLAEPHQAMLFDSYMLFRDKGLVLRVTESDLEDL*
>CYP528A1 N.
crassa AABX01000356.1 cont3.332 NCU05849.1 revised
8219
MSLPTLQDVLATSISLLKTTTPLLKRITSLLLKTTTSLLFIIVVTILAIA
VYRLFFHPLAGIPGPRLAALSNIWHAYHARNGRM YLLGKSLHKRYGPVVR
VGPNELWFDSKEAFKTIY
(1) 7866
7779
SAGSGFEKSDFY (1) 7744
7659 LSTLLTKPTLSLKFSPFKFP
FPNLQLPLQIHHPDTLDLLSERHLPRYRLQRRLIGPLYQLSSLKKFEPQI
DAVLDRAIAQLRTLQGQEVDLKEWMHIIAVECLGAVVLSWSPGYIRDKSD
GGTSVQGYLGWKRKSVFGLFPGITILSFLEG (1) 7207
7173
GVARWWSNTWGVTFATPKGFKPFFTAVYQKVSRRVSMAALLWMSDE (0) 7066
6953
MEEDKGKKDLLEDLIKLYQSKPEQFTETYLRRMAMTNFGAGHET
LCSALTACMAMIGTHAAVQARVAEEVGSHLRGGGTVPFDTAAKQLPYTLA
AIKEAQRLHPVIAMSLSRTVPRDLDGGGVMLHGHWVPEGTT
VGCNPVALHRNQEIFGEDADVYNPSRWLP (1) 6490
6154
LERKRLREMLHLNLTYGGGARTCPGRHLAELIVWKVIPRLVAE
FRVEVTHMPRDEEKNMERYFMSMLTGVKVRFLERREDSGDMA* 5897
>CYP528A2 Fusarium graminearum FG02458.1
AACM01000122 FGcontig1.122_scaffold1
142355 MMTLGSLLVSVFTR
142397
IICTLLVLVASIAIYRLYFHPLAHVPGPRFAAISSVWHAYNARNGRMAYLGKTLHRRYGP 142576
142577 VVRVGPNEVWFNTKEAFHAIY (1) 142636
142689 SSGSGYEKSDFY (1) 142724
142772 LATALNKPYIDWHLNPEFPDTLDLLSERDVRRYRIQ
RRLIGPVYQTSSLIQYEAAVDEVLARTVAKLKSLKGAQVELNEWMHIIAVECLGAIVLSWSPSMLKNGTD
NGSGTHAYHGWRRKSVFGLFPLAAKLEFLSKSTGRLFSTIWGVNFQPPKDFRPFFP
(0) 143257
143308
DVGKRASRRINAATKSKHHKDDRQDLLKDLISLHKSKPEFTVNYLRKMVITNFGAGHETM
ASTLTSIIAMLGSNNDIQEQVSREILETHNPADYSTATRLPKTQCLIKETKRLYPVIS
MSLPRTVPAGGLHLHNNYFPPNTTVGCNPVALHRNPEIFGSDCNEFKPDRWLTADSDA
ARNMERVSLSWGGGARTCPGRHLAELVVFKVIPALIKEFSIEAIVPPEDENRSYFLSM
LTSVKSDS* 144033
>CYP528A3 Magnaporthe grisea MG03500.4 49% to 528A1 AACU01000719.1 cont2.687
54% to AACM01000122.1 Gibberella zeae
MTFFWSLVVVATPALLVLAVAVYRLFFHSLAHIPGPRLAALSNVWYG
RQVCSGRMLQVGKILHRQYGPIVRVGPNEVWLDSEEGFRQVY
(1) SAGSGFEKSDFYL () 58238
58157 STALQKPKVDWRLQPHFPDTLDLLSERDMR
RYRLQRRLIGQVYQPANLRKF
EPVIDDVLDQVVAQIRTLGDAEVDLKEWMHIITVECLGAIVLSWSPGYLR
AKSDFGSGSFSYLGWKRKTVLG () 57789
57700 LFPLATVIGVLSRSFERQFANIWGLTFKAPKTLKHFFP
() 57587
57513 AVHRKVKPRLVNMS
REKPRKDARRDLMADLVQLHKERPEF
NGTYLHRMAITNFGAGHETTTSALTSVLAMLGTHLDIQARMADELVNSRG
TENEMASKDSSPRMPLTQAAIKEAQRLYPVIGMALPRRVPDGGVRIGDDF
LPAGTTVGCNPVSLHRNKDIFGPDADIYNPERWLTDDKRAKTMERNNLTW
GGGARTCPGKNLAEIILYKTIERLVHDFEVVCKLPPDEEICYYFMAMLTGVK
56788
HFDCLRAKEWTTAG*
>CYP528A4 Nectria haematococca
e_gw1.18.26.1
Necha1/scaffold_18:578149-579878
74% to 528A2 F. gram. ends donÕt match, 528A2
may have errors
MTLLCSLIAHVLLKTVFTLVVLLASIVVYRSTFHPLARVPGPKLAAITSFWHAYHARNGRMAYLGKTLHS
RYGPVVRVGPNEVWFDTKEAFQAIY(1)
SSGSGYEKSDFY (1)
LATSLSKPRIDWKLNPHFPDTLDLLSERDVRRYRIQ RRIIGPVYQTSNLIQ
YEAAIDDVIERAIAKLKSFKGAPVELNEWMHIIAVECLGSVVLSWSPGMLKNGTDWGSGSHAYHGWRRKS
VFGLFPTIVKLEFLSKTVGRLFSSAWGVNFKTPKNFKPFFV (1)
DVGKRVSRRVNAAKRASPPKDTRQDLLTD
LIRLHKVRPDFTDNYLRKMAVTNFGAGHETMASTLTSIMAVLGSLQDVQTQVSQEVLSMTDPSRYSTATR
LPIMQALVKEVKRLYPVISMSLPRKVPNGGLHLHGFYFPPDTTAGCNPVALHRNQDVFGPDSHLFNIARW
LNADPDTARNMERVSLSWGGGSRSCPGRHLAELVVFKVVPALVKEFRIEAVLPPEDDGRSYFLSMLTGVK
TRFIERQAAESTTDTQKPVS*
>CYP528A5 Mgr017 Mycosphaerella graminicola
54% to 528A2 N-term from JGI model
estExt_fgenesh1_pg.C_chr_70267|Mycgr3
cyan region does not match
MASLLNAIALVTVKAIVSVL
VLIIGIIIYRLYFHSLSNIPGPRLAGISNFWHAYHARNGRMLEIGTNLHRQYGPV
AGATQGYPKSSFY
VALALNRPSVTP
CLGLSFPDTLDLLGEFDLDRYRLQRRLIGPLYQTRSLLKHEKSINEVLLHAVARLKGLNGAPVDLKEWMHIITVECLTAV
VLSWSPGYLKAGTDHGVGPHAYLGWRRKSVFGLFPWAEVMDAYSRTLGRTFAKGWRLTYQPPAHYKALFPLLGTKVSKRI
NAALRPIPPKDGRNDLTAELIQLHKDKPEFSKDYLKRMVMTNFGAGHETTTSTLISVLTMLGLHAEAQGRVAAEISNTPR
ESQSVSYAEATDLTYTQAAIKESQRLHPVIGMSLSRRVPPAGLQVHGQYFPPGTTVGCNPISLHRNPEIFGPDAELFNPE
RWLHSSRVQDMERCNLLWGAGQRTCPGQALAKLIVFKVVATLVRHFKVEVEVPPEEEMKIYFMAMLTGVK
>CYP528A6 Mycosphaerella fijiensis
63% to CYP528A5 Mycosphaerella
graminicola
estExt_Genewise1Plus.C_110131 revised
MCHTIGTIFTLFGVVLVTVIIHRLCFHPLHRVPGPKLAAVSNTWHAYHARNGRMMSLGRTLHATYGPV
(0)
IYSATHGFEKSTFYIALALKRPELTRTLSLSFPDTLDLLGEFDMERYRLQRRLIGHIYSRRNLLKYEGTVDAVM
AGVVEHLRTLLGAEVDLKEWMHIITVECLSAIVLSWSPGYLRAGTDFGSSGHSYLGWRRKSVFGLFPTAEIMDNYSRSLG
RLFAKVWGLTFTPPANFKPFFPAVGNKCMRRINAALRSKPPNDKRRDLAYELIELHKSRPEFKSTYLKRMVMTNFGAGHE
TTTSTLIAVLSMLGSHAEAQDQVRDEVQDYARIDCYANACTLTYTQACIKEAQRLHPVIGMSLSRTVPANGTEIDGFYFP
PGTTVGCSPVALHQNPEIFGLDARDFRPDRWLKEDDAKIMDRYNLIWGGGARTCPGRALAEMIVQRVVSTLIKEFEIKVS
MPAEEDMPMFFMAMLTRVKACFRAREANPLSGG*
>CYP529A1 N.
crassa AABX01000356.1 cont3.332 NCU05874.1 (version3)
88106
METSNLTLLLLYLAIPSLLISAVQQILSWRKRTALVGSSGSKAKFPGPRQ
FPIVGRIHDLPRFSLWLKFKEWADEFGPIYTTSVPDATFVIISDEKIAEE
LLVKRGHIYSGRPQIRSLIGHKEGVVYSALMDRH
(1) 87705
87637
DTWKSQRKWAHAAMAA
AYKHHFYGHVESEMRRFLVVLLFDPDRFLDHTREYCGRVMSRLAWDDATQ
GRLNGESADKTLHCMSVSGPITNTMTPLWSLPASINPWYKYEVKREAELR
QWWLGLFRKAKERMRKGELPSDTWAYRYFEQMVQDTAPSMPATARAPGPD
VKNAERSPSTAAQEEAYEKKDALDQPEKDETFASCMIGFLNLVGVVTISG
PLKFFQMAMALHPEWQHKAQAEIDEVCGDRMPTMKDFDKLPILRACLKET
VRWRSGVPLGVPHQAERDDEFRGVKIKKGTIVLACEW (2) 86729
86660
TLNRNPQKYPDPE
TYNPARYLDPSYPTFQAPLTRYPNFREGSSMHSFGWGRRTCLGQNIVDDE
MFVFGAALLWAFEVTPKTCPVTGKEVPIDTHKTNSHVILEPVDFQLGYK
VREGKKELILEGGKEFFGKV* 86262
>CYP529A2 Magnaporthe grisea MG00832.4 66% to 529A1 AACU01001468 cont2.149
MEQIVLLLCYLALPTIFLTVVRHALSLVQKKPNSVAKFPGPKQYPIVGRI
HDLPRFSLWLKFKEWADIHGPIYQTRAVDNTFIIISDEKIAEELLVKRGH
IYSGRPQIRALIGHKEGPVYVALMDRHDSWTQQRKWVHAAMAEAYRNRFY
GHVESETKRYLAMLLLDPSRFLCHTREHCGRVMSRLAWDQAQQGAENGRS
ADETLHCMSVSGPIVNTVSPLWQLPWALNPWWRNEVRRESVQRAWWAGNY
HVARRRFLEGDLPADTWAHRYFDQLARDGNDALEQSPEQVDFASCMLGFF
SLVGAVTISGPLKFFLMAMALHPEWQRRAREEVDRVCGDRMPTVDDFAAL
PTVRAVLKETVRWRSGVPLGVPHQAEQDDVFRGVPIKKGTIVLACEWSLN
RVPEKYPDGDSFRPERWLEPGWPTFQEPLSKYPNFRNGHGMHTFGWGRRT
CLGQNIVDDEMFVFAAAMLWGFDMAQKLDRRTGEPVAIDTQATNSHVILE
PLPFEMAFKPRSEARAAGILRGYEEVRAGLRVVD*
>CYP530A1 N.
crassa AABX01000046.1 cont3.150 NCU02852.1 (version3)
43902
MAVITTYLPIVVGIALLIRLLMVGRRPKNYPPGPPTIPILGNLHL (0) 43768
43698
MPTKDVHLQFEKWAREYGPVYSLILGTKVMVVLSSDRAVKDLLD
KKSHMYSHRQEMYVGQTLCSGDMRILMLGYTA
KWRMSRKLVHALLNVSSAKSYVPYQMLEN
KQMLYEMITKPDEFLYNIRRYSNALTTTMVYGWRTPTYNDEKMRQLFDGF
SEFAEINQTGVAALIDFFPILRYLPDFLLPARKKAKELHKKELGLYKGHW
LKAKEVTLKGTITHCFCEDAVPVQKKEGFSDDEAAYIAGTLLEAGSDTTS
STLYGFVQAMLLYPEVQRKAQEEIDRVVGPDRLPTMDDEPHLQYCRAIVK
ESLRWMPTTIMGAVPHAVTQDDYYNGYLIPAHAAVVNNAWAINHDPVRAP
EPRKFKPERHLDDKLSLADSAANPDPTKRDQFTFGAGRRICPGIHVAERS
LFLGVARMLWGFSIAPKIGVDGKEIIPDQEKLTQGFVCMPEEYPATITPR
DERRKGIMEEEWFAAERECLDPETKQWKQGMNWVPKLSSTKV*
42205
>CYP530A2 Fusarium graminearum FG11389.1
AACM01000465 FGcontig1.465_scaffold9
revised, 77% to CYP530A5, 76% to 530A9
MFTLQVFFLALGAVLVRLLFTGRRPKDYPPGPPTIPILGNIHLMPKRDAH
LQFRKWADEYGPVYSLILGTKPFIVLSSAQAVKDLLDKKSGIYSDRQE
MYVGQVLGSGGLRLLMM (0)
GYGQTWRS (0)
FRKLVHSLLNVTAAK
SYVPYQDLENKQMLYELVTQPDQFLQSIRRYSNALTTTMVFGWRSPIYQD
PKLMQLFDGFADFAEINQTGIAALLDTFPILRRLPDFLLPVQKKAKELHK
KEKALYLSHWLKAKQDIANGSIKPCFCVGLAEAQEKNKFDDDQAAYISGT
LLEAGSDTTSSTLYAFVQAMLLYPDIQRRAQDEIDKVVGNAQMPNMDDES
SLQYIRACMKETLRWMPTTILGAVPHAVTQDDIYNDYLIPKGAGVLNNVW
GIHMDPERYPNPRQFNPERYLDDFQSLADAAANPDASKRDQFTFGAGRRI
CPGIHVAERSLFLGMSRILWAFNIEPALDEMGRPILPDPDKLTQGFVCMA
EEFPAKITPRSAEKRDLVIESWRNAEKELLDPVTKQWR*
>CYP530A3 Aspergillus nidulans
AACD01000151.1 revised
revised 7/19/07
MLPLTPILAIAGLLALIFRLSLIGRRPKNYPPGPPTLPLLGNIHQMPSRD
AHLQFAKWAKEYGPIYSLMLGTQCLIILSSDEAVKELLDRRSGIYSHRQE
MYTGQQLCSGGLRMLMMGYGPTWRIMRKMVHGLLNVSTSRNYIPYQMLEN
KQMLYQFLTEPDDFLKHIRRYSNALTTTMVFGWRTPTYEDPKMKQLFDGF
SEFAEINQAGAAAFLDFFPLLQKLPDFLVPTKRKAKELHKHEMGLYKGHW
MKAKEEIEAKNIKPCFCQGMYEVQKKEGFSDDQAAYISGTLLEAGSDTTS
STLYAFVQAMLLYPEIQRKAQAEIDRVIGPDRLPVMDDLADLQYIRSCMK
ETLRWMPTTILGAVPHAVTQDDSYMGYFIPKGAGVMNNVWAIHHDEKRHP
NPRQFNPDRYKDDTQSLGDAAANPDASKRD
AFTFGAGRRICPGIHVAERSLFLGMSRILWAFNISPKKDASGKEIIPDQERLTQGFVCMP
EEFPATITPRDEKRAEMVRNEWRQAEKELDSETKQWVVAPVDIKI*
>CYP530A4 Nectria haematococca
e_gw1.14.490.1
Necha1/scaffold_14:351965-353894
49% to 530A2
MLSLLISVVLSFTALAVLLLAKLSKIGQRPPGLPPGPPTLPLLGNLHL
(0)
MPTKRPHLQFEKWAKQYG (2)
PIYSLILGTKIMIVLSSDEAVKDLLDKRSAIYSDRPDMYIGQRIASGGLRLVLM
(0)
RYGSNWRMIHRMIHKALNITVAATYLPYQDLENKVLLTNLLDTPDDLL
PHIRRASYSLSTQMIFGFRCISNQDPKLLQLFH (0)
GFDKWSALSGSASAQLADLYPALQNLPDFIAPNVSYARKLHQAEKKMYLGHWARTKQAIVDGRGL
(0)
PCFCNDIYRAQLTEGFSDDAAGYISGSLLDAGSDSTASTLYGFILAMLIWPNVQKRGQEEVDRVVGPD
RLPTMEDYDQLPFIRCCIKETLRWMPTVVLGVPHNVTKDDSYLGYQIPKNSSIINNVW
(2)
AIHMDETRCPEPRVFNPDRFKDIPSTLYQSVIGDVAKRDNFVFGAGRRLCQGIHIAERSLFLAISRFFWG
FNFLPTKDEYGHPVQYDAEDLVGGITVQPADFPAVIEARSKRRADIIRKEAQESEKSLDPETLQWIKVPEGMVFNNE*
>CYP530A5 Aspergillus fumigatus
AAHF01000014
complement(join(613367..614597,614640..614689,
614717..614932))
locus_tag="Afu8g00760" third P450 of 8 on this
accession
54% to CYP530A4, 77% to 530A2, add missing first exon
79% to 530A9
revised small exon
MLPLALVGAVGALVFLVFRLLSIGRRPKNYPPGPPTLPIIGNIHQ (0)
MPTRDAHLQLQKWAQEYGPVYSLILGTKPLIVLSSDQAVKALLD
KRSALYSHRQEMYIGQTLCSGGLRMLMM (0)
GYTPVWRG (0)
FRKMVHGLLNV
TAAKSYVPYQMLENKQMMYEFLTQPERFLYSIRRYSNALTTTMVFGWRTPTYEDAKMK
QLFDGFSEFAEINQTGTAALIDFFPWLRMLPDFLLPTQKRAKELHEREKALYLGHYLR
AKQDIRDGQIKPCFCVGLAEAQKSDGFSDDQAAYISGTLLEAGSDTTSNTLYAFVQAM
LLFPDVQRKLQEEIDRVVGPRMPTMDDEQDLQYVRACMKETLRWMPTTILGAVPHAVT
QDDEYMGYLIPKGAGVVNNVWAIHMDEKRHPNPRVFNPDRYKDDRQSLAEAAANPDAT
KRDQFTFGAGRRICPGIHIAERSLFLGISRMMWAFNVEPAVDEKGQPILPDPDRLTQG
FVCMPEEFPARITPRSQAKADMVIKEWKEAEQQCLDPETKQWLLSPVQ*
>CYP530A5 Neosartorya fischeri
95% to CYP530A5 Aspergillus fumigatus = ortholog
NFIA_094190
MLPLAVLGAVGALIFLVFRLLSIGQRPKNYPPGPPTLPLIGNIHQMPTRDAHLQFQKWAQEYGPVYSLILGTKTMVVLSS
DQAVKDLLDKRSALYSHRQEMYIGQTLCSGGLRMLMMGYTPVWRGFRKMVHGLLNVTAAKSYVPYQMLENKQMMYEFLTQ
PERFLYSIRRYSNALTTTMVFGWRTPTYEDEKMKQLFDGFSEFAGINQTGTAALIDSFPWLRRLPDFLLPTQKRAKELHE
REKALYVGHYLRAKQDIRDGNIKPCFCVGLAEAQKSDGFSDAQAAYISGTLLEAGSDTTSSTLYAFVQAMLLFPDVQRKL
QEEIDRVVGPRMPTMDDEQDLQYVRACMKETLRWMPTTILGAVPHAVTQDDEYMGYLIPKGAGVVNNVWAINMDEKRHPN
PRVFNPDRYKDDRQTLAEAAANPDATKRDQFTFGAGRRICPGIHIAERSLFLGISRMMWAFNVEPALDEKGQPILPDADR
LTQGFVCMPEEFPARITPRSQAKADMVIKEWKEAEQQCLDPETKQWLLSPVQ*
>CYP530A6P pseudogene Nectria haematococca
e_gw1.10.737.1
Necha1/scaffold_10:90207-90395
37% to 530A2
PQRGSRLPLPPNPKGHQLLRNLLDLIKHAKDGNIHLLF*RWSKQDGKIFRLGSLE
SYYLNNDEAVNVLMDK*SANTSGRPRWISSSEHMTNSWNVLLLDSIKPRWKKHRKVLNSALT
ESFEEAAFTALALILGAADASAISTWSFLEAMLLFPNV*EKARSMVLEVTKDRTPVYEN
LHDIPYVRCLMKET*R*RPLIPLGHPHSTSEDINYEGYRIPKGAGLHLNAFAVGHQEKRN
HNPEMFNVMGRIQPHPSRA*
NLADVTKRDHFAFGPGRRACPRYHAAERSLAIAIMRILWAFEICPAED*
ELPLDPSKFEGRVMPRPPHERLPVCLRVLDEK
>CYP530A7P pseudogene Nectria haematococca
fgenesh1_pg.scaffold_44000004
Necha1/scaffold_44:12309-13331
43% to 530A2 EXXR motif mutated to KTFR
probable pseudogene
AMVLFPEAQKRAQEEIGSIIGNGLLPEWNDRKDLPYIHGVVEKTFR
(1)
WVPSTPSAAVPHSDKEDDVYNGMVISKRSM (0)
LKTPLSAKTTRRLHFNFGAGRGVCPGFHVSERNLFLAISRIL
*GFTINPTRDFGGAIVPINRDAVTPGLIVRPEDFESQASHHGSLVKGRKHLDSEGNFTPEF
IDSVFGKEK*
>CYP530A8 Mgr038 Mycosphaerella graminicola
66% to CYP530A3 Aspergillus nidulans
probable assembly error in the yellow region
(or a pseudogene)
green from JGI model restores EXXR motif, cyan
may be intron seq
MERPSIAVLVALVVFLYGFVRLLSVGRRPKDYPPGPPTIPVLGNIHQMPTRDAHLQFEKWAREYGDIYSLMLGTQTMIVL
SSDEAVKELLDRNSGNFSNRLEMYVGQVLMDIHPNGEVYASAFLLAVRGSATNAMQFRKMIHHLLNATVAPQYVPYQILE
NKQMLNDLLDTPNDFLKHIRRYSNALTTSMVFGWRTPTYEDDAVKQLFDGLSEFADINQTGVAALLDAFPLLRKLPETLL
PVQKKAKELHKVERELYLRHWLRAKKEIKEDTIKHCVGMAEAQKKEGFSDAQAAYISGTLLEAGSDTTSSTLYAFVQAML
XXXXXXXXXXXXXXXXXX
LSLKFSGMLSSSLIKSSTNDPDLG
AELPYIRMIMKETLR
WAPTTVLGAVSHVTTEAATYKGYYIPAGAGVMNNVWAIHNDPARSPNPHLFDPNRF
KDDKLSLYDSTSNPDPSKRDCFTFGAGRRICPGMHVAERSLFLGMARLLWAFSIKPAKDADGNEIVPQGQKFTQGFVCMP
EEFPADIVRTEWQVAGSQSLDHDTKQWIASPI
>CYP530A9 Uncinocarpus reesii
78% to CYP530A3 Aspergillus nidulans, 79% to 530A5
UREG_06613.1
MPKRDAHLQFAKWAKEYGPIYSLMLGTQCMIVLSSDEAVKALLDKKSGIYSDRQEMYIGQRVCSGGLRLLMM
(0)
EYGPRWRG (0)
FRKMVHGLLNVTTSKSYVVYQVLENKQMLYEFLTEPDRFLYHIRRYS
NALTTTMVFGWRTPTYEDQKMKQLFDGFSEFAELNQAGAAA
LIDFFPWLRKLPDFLLPVHKLAKELHKHERALYLGHWLKAKEDIRKGTIKPCFCVGMAEAQKYDGFDDAQAAYISGTLLE
AGSDTTSSTLYAFVQAMLLYPDIQRRAQQEIDKAVGPDRLPDMNDQESLQYIRAIMKETLRWMPTTILGAVPHAVTQDDH
YMGYLIPKGAGVMNNVWAIHHDEKRHPNPRVFDPDRYINDRQSLGESAANPDGTKRDQFTFGAGRRICPGIHVAERSLFL
GMSRILWAFDIAPAPDAQGRPIMPDPDRLTQGFVCMPEEFPAKITPRSKERADIVTREWKAAEKTCLDPETKQWLLHPIDS
>CYP530A10 Coccidioides immitis
88% to CYP530A9 Uncinocarpus reesii
CIMG_04939.2
MLRLSVLLGLTAAAIAVARLLSIGRRPKNYPPGPPTLPLLGNIHQMPKRDAHLQFAKWAKEYGPVYSLILGTQCLIVLSS
DEAVKALLDKKSGIYSHRQEMYIGQEVCSGGLRLLMM
GYGPKWRG (0)
FRKMVHGLLNVTTSKSYVVYQTLENKQMLYEFLTEPDRFLYHI
RRYSNALTTTMVFGWRTPTYEDAKMKQLFDGFSEFAEINQTGAAALIDFFPWLRNLPDFLLPLHKKAKDLHKHEKALYLG
HWLKAKDDIRRGTIKPCFCVGMAEAQKSEGFDDDQAAYISGTLLEAGSDTTSSTLYAFVQAMLLYPEIQRRAQKEIDEVV
GADRMPNMDDQDSLQYIRAIMKETLRWMPTTILGAVPHAVTQDDHYMGYLIPKGAGVMNNVWGIHHDEKRHPSPRVFNPE
RYINDHQSLGESAANPDGTKRDQFTFGAGRRICPGIHVAERSLFLGMSRILWAFNIEPASDSQGRPIIPDPDRLTQGFVC
MPEEFPAKITPRSKARADFVTREWKEAEKACLDPQSKQWLLHPLE
>CYP530A11 Fusarium oxysporum
87% to CYP530A2
FOXG_13473 revised
MLTVQLFWVALAAIFVRLLFTGRRPKNYPPGPPTLPILGNIHL
MPTKDAHLQFRKWADEYGPVYSLILGTKPFIVLSS
AQAVKDLLDKKSALYSDR
QEMYVGQILGSGGLRLLMM
GYGPTWRSFRKLVHSLLNVTTARSYVPYQDLENKQMLYEMIVQPDQFLQSIRRYSNALTTTMVFGWRSPIYRDPKLMQLFDG
FAEFAEINQTGIAALLDSFPVLRKLPDFLLPVQRKAKELHKKEKDLYMSHWLKAKQDIADGSIKPCFCVGLAEAQEKEKF
DDAQAAYISGTLLEAGSDTTSSTLYAFVQAMLLYPEIQRKAQDEIDKVVGKRMPTMDDEQSLQYVRACMKETLRWMPTTI
LGAVPHAVTQDDTYNGYLIPKGAGVLNNVWGIHMDPERHPNPRQFNPDRYRDDFQSLADAAANPDASKRDQFTFGAGRRI
CPGIHVAERSLFLGISRILWAFNIKPTVDKNGKPVLPDPDKLTQGFVCMPEEFPARIIPRSEEKKAQVIESWKKAEKDVL
DPETKQWR*
>CYP530A11 Fusarium verticillioides
96% to CYP530A11 Fusarium oxysporum = ortholog
FVEG_13927
MMLTVQLFWVAVAAIFVRLLFTGRRPKNYPPGPPTLPILGNIHL
(0)
MPTKDAHLQFRKWADEYGPVYSLILGTKPFIVLSS
AQAVKDLLDKKSALYSDRQEMYVGQILGS
GGLRLLMMGY
GPTWRSFRKLVHSLLNVTTAKSYVPYQDLENKQMLYEMIVQPDQFLHSIRRYSNAL
TTTMVFGWRSPIYRDPKLMQLFDGFAEFAEINQT
GI
AALLDSFPVLRKLPDFLLPVQKKAKELHKKEKDLYLSHWLKAKQDIADGSIKPCFCVGLAE
AQEKEKFDDAQAAYISGTLLEAGSDTTSSTLYAFVQA
MLLYPEVQRKAQDEIDKVVGERMPNMEDEHSLQYVRACMKETLRWMPTTIL
GAVPHAVTQDDTYNGYLIPKGAGVLNNVWGIHMDPERHPNPRQFNPDRY
KDDFQSLADAAANPDAAKRDQFTFGAGRRICPGIHVAERSLFLGISRILW
AFNIKPTVNKNDKPVLPDPDKLTQGFVCMPEEFPARIIPRSEEKKALVIK
SWKAAEKDVLDPGTKQWR*
>CYP530A12 Fusarium verticillioides
53% to CYP530A3
FVEG_08430, not found in F. oxysporum genome
MSFSASVYLLIPVLILGLW
RLSTVGRRPAGYPPGPPTLPIIGNLHQIPNRKRHIQFQKWAEEYGPIYSLILGRKVMIVL
NSDQTVKDLVDKRGGIYSSRPESYIGQDVLSGGYRILFMVY (0)
VWKMARKLVHRILGVTAARSYIPYQDLESKAML (2)
NAVRFLKSSDDFVDHLRRYTASLTTQITFGSRTTSIQDERFKEAFD
(0)
IFDRSSEMIGSR (0)
TAALLDLVPALRRIPDFLMPIKKEGRKIHYRELSLFRGFYLAAKKGLE
GGSAKPCVCVDLVKLQKEEGFSDTFASYLSGSLLQAGSETTASILIG
FVQAMVIFPDVAKTARGELDRVCGDRLPNLDDTPDLPYIHACMKESLR
WMPGFMLGIPHATTQHDSYLGYHIPKGATVIINVWAIHNDPKRHPSPRQFDP
MRYINDQQTSIEAANNPDPTKRDHYVFGAGRRRCQGMHIADRSLFLAI
SRLLWAFNFDRDVSAETGKAIIPDAEDVIEGIMSIPSPFPVRIVPRSTKRAE
AVAAAWSQAVDLLDEHGQWKVVPEDLLWTIPES*
>CYP530-un1 pseudogene Nectria
haematococca
gw1.271.3.1
Necha1/scaffold_271:2439-4371
35% to 5047A1
39% to 530A3, 37% to 5056A1
MSISSASFLTLALPLIVAIALLEYGRKAIRSKSLPPGPSTSLFL (1)
GNLHQVPSSKAYLQ (2)
FQKWAKTYGPILGLKLGPQNLIILNSASLVRD (2)
LFDKRGAIYSSRTPNYIGSEIITRDNAHLLLMPYGPEWRNQRKAFQSILNITAVVSLQ
GLQEAEAVLTMSQLLQSPEQYYDHIRRYSTAVILSSVYGIRGPEFNHPNIQRLYHVQDQFTAILETGATP
PVDTFPFLKHLPTFLASWRRWALSIRREQRQLYFELLDNAKSRIQRGVHRGCFMDGLLSEDKRAKYSLDD
EHIAYVGGVLMEGGSDTTASTLLSFLMAMMKYPHVLRKAQKEVDKVCGLQRSLNFEDVGKLTYIR*CMTE (0)
TLRWRPVAAGGIPHV LIQ (1)
DDTY*GY*FPKGSIFIVNAW (2)
AIHYDPDIYDRPEEFRPERYEGNEFGFKEHP*DASSLRKTYAFGAGRRVCPGQHLAENSL (0)
VINMAKLVWTFNMLPGEDPTTGKQLSVSEIDDSMATAWTNGFLTAPKKFPLLLA
VRSREHERVIKRECLEA*
>CYP530-un1 Aspergillus terreus
64% to CYP530-un1
ATEG_03951.1
MANVASTLILFSLFCCWVGWKIIYIARGGHRSPSLPPGPPTLPFI
GNLHQIPAQKAFLK (2)
FQEWSR*YGPIISLKTGPANLVILNKAKDVR (2)
LFDKRGAIYSSRLPNHIGNELITRDNVHLLL
MPYGQAWRNQRKIYQAILSITAVRSLTPLQEAEATLTLYQLSQTPELYYDHIRRYSTAVILSSVFGIRGPEFDHRNITRL
YHAQDQFTGILETGATPPVDIFPFLKRLPDFMSPWRRWARQIRAEQRQLYFELLQEVKSQRARGIYRNCFMSQLLDEKFA
EKYELDEEHIAYIGGVLMEGGSDTTASTLLSFLLAMTKYPKVFQKAQEEVDRVCGMSSSPTFDLIAKLPYVKHCVSE
(0)
VLRWRPVAAGGLPHVLIQ (1)
NDEYKGFNFPTGTTFLANTWAIHHDPELYDRPDDFIPERYEHHPLGFKTDIKKTTDGIRKTYGFGAGRRICPGSHLAENSL
DINIAKIIWAFNIRAGTDPTTGRHLQDEEVNVDVATQWTDGFLIAPKPFPIVMELRSEKHREVF
RRELEDARKVFQSYED
>CYP531A1 N.
crassa AABX01000205.1 cont3.366 NCU06327.1 (version3)
138867
MDSHAGLDGVLQPQVLKLTLRTLPSPFISFVVIPILSILGWYI
ISWATNPLKKYPGPFLA (1) 138688
138607
GFTNWWRLYQTRTGRYHEIVYDLHKKYGPIVRIGPNTLDLDYP
ELIKTIYSTDGKWLK (0) 138434
138374
TEFYHNNSAIVNGKITYHIFSTTSPTEHAKMKRPVAKYYSTSY
VQALEPHVDVVLNDFCKYVEERFINVPGGPKELDFGEWLGY (1) 138123
138042
HAWDLISSVTFSRRFGYMEHGSDFDGTIEKAEAALRYFQTVGQ
IPILDYFLDKNPIKRVGPPNLVHPARIAVQSFVARLQGKDENY
DPKNPDYLQHFIDSKESHPDLVDDNQIISDVLVNLLAGADTTA
IALRAVFYYMLKNRSVYNRVSEEIQAAGFDRSKPVPYSGARQL
PYLEACVREALRIHPAAAMLLERYVPADGITLPDGSFVPAGTA
VGLNPWVVSRNKSIFGEDSDTFRPERWLQQPGEDDEAFHVRMQ
KWNAADLTFGNGSRICTGRNFAMFELYKVCATLLHRFEIELAD
PTKEWKVWGSWFTIQKDVIAKMKVRG* 137062
>CYP531A2 Nectria haematococca
fgenesh1_pg.scaffold_15000295
Necha1/scaffold_15:796534-798330
60% to CYP531A1 N. crassa, 49% to 531C1
MSSIDTSYIEALVQGLDWKSLATAIVVVPILSITAWWIVSYFTSPLRKFPGPTLA
(1)
GWTNLWRLSVVRKGSYHVKIKELHNKYGPVVRIGPNTLDFDFPELIKTLYGTDGKWKK
(0)
TEFYHNNSAVVNGKITYHLFSTTDQAE
HARMKRPVVKYYSQSSVIGLESLFDSLIGDFCGHLEKRFMNGTEPTECDLGEWIGF
(1)
YSWDANGAASFSQRFGYMDKGYDYDGTISIADKALDY (2)
FAAVGQMPFLDFLLDKNPVMRIGPPNLGNITRISLEHLISRLQGKDTNYNPKVPDFLQHFIESKETHPDL
VNDGIIMGYLLVNLLAGADTTAITIRAIFWYALHNPRAYKKLEEEIVAADLADVASFSSARALP
(1)
YLEACAREAMRMHPGVCMLLERYVPETGLKLPDGSFVPPGTAVGINPYVAGRN
KTIWGEDADTYRPERWLQGEGETDAAYKERLRLYNAADLTFGGGSRVCIGRNLAQLELYKIVATLIKKYE
ISLVDPDQPWVVTGSWFPRQKGLKCYLKKRE*
>CYP531A3P Fusarium oxysporum
51% to CYP531A2 Nectria haematococca
FOXG_13597
MITQSSPTELSYVGTTVVLFAVLLWWIISTLTSPLRPYPGPLFA
(1)
KWTNLWRLYQVRTQKYQWTIQDLHKKYGPIIRIGPN
LLDLDYPELIKIIYGTDHRWLK
(0)
FYLNNSSMVDGKIKHNLFSTTSPAEHAQMKKPMAKYYSSSNVLTMEVKMNQVIKELCK
QIDNRFLEDNKSFDLAELLGL
(1)
YTWDMIGSLTFSQPFGYMKKGHDFDGTIIASALSVDYFAQIGQMPFLDWLLNKNPMVRI
GPPDMSHVTHFSIAQLQRRLEQQEQRKSSEEPDFLDHFIDGMKSNPDSVDAKLVLNFLLANVLAGADTTVIALRAIFDFL
LQNQHAMTKLKSEILTLGFNDAEAVPYSRARSLPYLDAVIRESLRMHPSVAMPLERYVPNTGLTLPDGSFIPPGVAVGLN
PYIIGRNEVVWGEDTH*FRPDRWIKAEDESEGEYQRRLRKMNGADLT
FGGGSRICIGRHIALIQIYKAVATLVSRYDIQLADQ
NVRMKIISGWFPLQTGLFVRMRKRSEMGKL*
>CYP531A3 Fusarium verticillioides
80% to CYP531A3P Fusarium oxysporum, probable ortholog to
the pseudogene
FVEG_11028
MDNLSIFTAIALCAALIWWVISTLMSPLRQYPGPFLAKWTNVWRLYQVRSQKYQWTIQELHKKYGPV
VRIGPNLLDLDYPELIKTIYGTDNRWLKFYLNNSTIVGGKISHNIFGTTSPAEHTQMKKPMAKYYSS
SNVLTLESKMNQVIEELCKQIDDRFLKGTESFDLAEWFSLYTWDIIGFLTFSQSFGYMIKGHDFDET
IMASALSVEYFAQIGQVPFMDRLLNKNPIVRIGPPDMSHITHFAITQLQRRLEQRDQDIHLEEPDF
LDHFIDGMNRNPDSVDASLVLNFLLGNILAGADTTSIALRAIFDFLLQNPHAMAKLKAEILAEGFDD
DAVVPYSTARSLPYLDAVVRESLRMHPSVAMPLERYVPDTGLTLPDGSFVPPGVSVGLSPYIIGRNE
RVWGEDANEFRPERWLKTEDEDDEDYQRRLRKMNSADLTFGGGSRICIGRHIALIQIYKVVATLVSR
YEIQLADLNVRMKIISGWFPRQTGLFVKMHKR*
>CYP531A4 Fusarium verticillioides
83% to CYP531A2, 49% to CYP531A3P
FVEG_14002 revised, no ortholog in F. oxysporum
MPSIHSTSYLHTLVQRSDWKRISAAFVFVPVLSIATWWIVTYFTSPLRKYPGPRLA
(1)
GWTNLWRLWTVRKGSYHIRIKELHDQYGPVVRIGPNTLDLDIPELINTLYGTDGKWKK
(0)
TEFYHNNSAVINGKITYHLFSTTDQAEHARMKRPIVKYYSQSRVIGLEPL
FDGLISEFCDHLEQRFMSGPEPTGFDFGEWIGFYSWDANGAASFSQRFG
YMDKGYDYDNTISIADKALDYFAAVGQMPFLDFLLDKNPIMRIGPPNLANI
TRISLEHLISRLQGKDENFDPKVPDFLNHFIESKKTNPDLVNDGIIMGY
LLVNLLAGADTTAITIRAFFWYTLHSPSVYSKLEKEILAAGIDNVASFSS
ARALPYLEACVREAMRMHPGVCMLLERYVPESGLKLPDGSFVPQGTAVGI
NPYVAGRNKGVYGDDADSYRPERWLQNEGETEEEYNKRIRLYNAADLT
FGSGSRVCIGRHLAQLELYKIIATLINKYEISLVDPAAPWVVTGSWFPRQRGLDCYLKKRA*
>CYP531A5 Fusarium verticillioides
62% to CYP531A2 Nectria haematococca
62% to CYP531A4 Fusarium verticillioides
57% to CYP531A3P Fusarium oxysporum
FVEG_06505, no ortholog in F. oxysporum
MTLNVILLNYSLTTLLFGGITALLAAAIIWLVFSELTSPLRSYPGPF
LARWTNLWRLYQVQTQKYQWTIKDLHEKYGPVVRIGPNLLDLDHPELIKTIYS
TDGKWCKTEFYHNSSAVINGKITYHLFSTTDQAAHARLKRPIVKYYSM
SNILNLESHVDTVISDFCDHLETRFMDKQSQEKQFDFGQWIAF
(1)
YTWDMISSATFSQRFGYMEKAYDFDGTIH
TADQVTDYFAMVGQMPFLDYLLDKNPIKRIGPPNLGNVTRISVEKMMSRVDK
LDEIDRKPAEELDFLDHFLNAMKKSPDLVDTSVITGYLQVNMLAGADT
TAITLRAIFNFLLENPRTMTRLKEELLSLDYDGTKEKIVSYKSARAVPY
DAVIRESMRMHPGVGMLLERYVPDTGLQLPDGSFVPGGTAVGLNPYVIGR
NKGIWGDDADEFRPERWLPKTGEGDEAFQQRLRQMNGADLTFGGGSRICIG
RNLALLEIYKVVATLVSRYEILSVPGQKMKIISTWFPRQSGLICQLRKR
>CYP531B1 old name = CYP569A1 Magnaporthe
grisea MG07856.4 44% to CYP531A1
AACU01000959.1 cont2.1455 PROBABLY SHOULD BE
CYP531B1
MSAAAVATWAFVLLATCAAWNVLSCWRSPLRRYPGPFLARWTNLWRFYHT
LRGDIHLVNLRAHQRYGPVVRTGPNQLDLDLPALVKTIYSSDGRFRKTDF
YPPASTVVDGRVAYNLFSLRDPAEHARQKRPVAKHYSLAGTLALQPHVDD
TIRLLRRSLDERYVGADGFGEGFDLGEWVKMYAWDVIGQVTFSKHFGYLS
SGRDFDGHLWMSDRGADYLSSVSQIPWLDRIVDKNPIFPVGGATALLGPT
MKRLDDRYAGRDDRDPVQAAAQPDFLDRFLEVQRAQPDVVDRQRVLSYLS
INMLAGADTTAITIKAVLYYALRTDGVWGRLVTACEDAGLAAGEIASFAQ
ARAVPYLEAVVREAMRLHPGVAMVLPRCVPDGGLELPDGNVVPPGTSVGM
NPFVLGRNRTVWGPDADDFRPERWLRADGETEEAFAVRLAAMNAADLTFG
AGSRVCLGKHLGLLQAYKVVATLAVSYDLEMLEPEKEWWVRSAFFMRQGE
LKVSMRRRD*
>CYP531C1 Fusarium graminearum FG02982.1
AACM01000145 FGcontig1.145_scaffold2
MSKHTLYETSILGPARNIFSLVSPSVFLLLVVPASTLSLWTLASYFTSPL
KKYPGPFLAKFTRLWYMYQASTGDSHLVLERLHKRYGPIVRITPDIIDVD
IPEIINTIFSTKDDWLKTPFYHGSSALVNGHIVLNTFSQTDPVKHKKGRQ
PIAKLYSSAGVSTLEPHMNKVINQLCDELEKRFTGHNAGQVCSLGQWILF
YAWDVVGAITFSQPIGYLKKGCDFDGTLKNADKAMDYFTVVGTMPFLDRI
FDKNPVFHMGPPGFNTSTEISVKHLIDRYQGNDKENHDPAHPDFLDKFIE
IKNSKPDEADDAQIISWLMVNMIAGADTTAITIRSVLYFSLKHPRVWKRL
TEEILRAGFQQVPAYKDVKALPYTDAVCREALRMLPGVAMTMERFVPKEG
FVLPNGDFLPGGTIVGMNPYIVARNKSVYGDDADDFRPERWMRSEDETEE
QYQIRLLAMNQADLSFGGGSRICIGKYIGLFQTYKVIAILLTRFEIELAD
PNKEWKVTNSWFPRQEGLEARIRKRTGSRLPKSSY*
>CYP531C2 Nectria haematococca
e_gw1.27.133.1
Necha1/scaffold_27:386590-388379
76% to 531C1
MNHTSYLDTSILESAEGILRSNSSLFLYLIVPVSTISLWTIGSYFSSPLKKYPGPFLA
(1)
KFTRLWYLYQAW
TGDSHLVLDKLHKQYGPIVRITPSIIDVDIPELIKTMFSIKGDWLK
(0)
TPFYHGSSALVNGQIVYNLFSQTD
PVQHRKERQPIAKHYSSAGITTVEPHMDKVIDQFCNELEKRYIAGDNAGKVCDIGQWTLF
(1)
YTWDVVGAVTFSQPIGYLEKGYDFDGTLSNADKAMDYFTVVGTMPFLDRVFDKNPVCHIGPPGFNTITGISIKHLVDRYQ
GNDKDYHDPEKPDFLDKFIEAKNADPENVNDPQIVSWLMVNMIAGADTTAITIRSSLYFSLKNPSVWNRL
TDEVLAAGFYGRTPPSYKEVKALPYVDAVIREALRMLPGVSMTMERYVPREGFVLPNGDYLPEGTIVGMN
PYILARNKSVYGEDADTFRPERWLRDEANGETEEQFQKRLLLMNQTDLSFGGGSRICIGKNMGLFQTYKV
LATLITLFEIELADPKKEWKVINSWFPRQEGLEVKLKKRAL*
>CYP531C3 Aspergillus oryzae
GenEMBL
BAE65935.1
58% to 531C2
MDSFLFLALDYSLRGFAVSLFGTLWIALVFWYLATYLISPLRKIPGPFLAGWTNLWRMYHVTQGQSQVVL
HELHQKYGPVVRIAPNVVDLDLPEMIKTIYNTKGDYRKTEFYHGSSAKSNGRIIYNLFSECDPDIHAQQK
RPIAKYYSLTGVLPLEPHIDEVINYLCQRLEEEFINGLNAGITCKLDQWLLFYTWDVVGQATFSEPIGYL
KNGFDFDGTIAISDTAMDYFSLVGQLPVLDHLLDKNPIYRIGPPAFGNITNISITHLLDRLQGKDTSYHD
ANKPDFLDRFIDAKDKYPDIVDDSQIISYLMINMIAGADTTAITLNAAIYFALKDRRVWARLQKEIRACQ
SSLDAAPSAVPYNIASALPYLNAVVREAMRMHPGVAMTLERYVPPGGLTLPNGQYIPQGSIVGMNPYVIA
RNRSVWGEDSDVFRPERWLRDDSQESEEEFQARLRLMNNSDLAFGAGSRICIGRNLGLLEVYKVMATLIS
RYDIELAHPHRDWKTHNSFFVRQEGINVKLSRRS
>CYP531C3 Aspergillus flavus NRRL3357
AAIH02000016.1
98% to CYP531C3 = ortholog
AFL2G_11285
40898
MDSFLFLALDYSLRGFAVSLFGTLWIALVFWYLATYLISPLRKIPGPFLA ()
40659
GWTNLWRMYHVTQGQSQVVLHELHQKYGPVVRIAPNVVDLDLPEMIKTIYNTKGDYRK 40486
40485
TEFYHGSSAKSYGRIIYNLFSECDPDIHAQQKRPIAKYYSLTGVLPLEPHIDEVINYLCR 40306
40305
RLEEEFIDGSNAGITCKLDQWLLF (1)
YTWDVVGQATFSEPIGYL 40126
40125
KNGFDFDGTIAISDTAMDYFSLVGQLPVLDHLLDKNPIYRIGPPAFGNITNISITHLLDR 39946
39945
LQGKDTSYHDANKPDFLDRFIDAKDKYPDIVDDSQIISYLMINMIAGADTTAITLNAAIY 39766
39765
FALKDPLVWARLQKEIRACQSSLDAAPSAVPYNIASALPYLNAVVREAMRMHPGVAMTLE 39586
39585
RYVPPGGLTLPNGQYIPQGSIVGMNPYVIARNRSVWGEDSDVFRPERWLRDDSQESEEEF 39406
39405
QARLRLMNNSDLAFGAGSRICIGRNLGLLEVYKVMATLISRYDIELAHPHRDWKTHNSFF 39226
39225
VRQEGINVKLSRRS* 39181
>CYP531C4 Aspergillus fumigatus A1163
ABDB01000058.1
94% to CYP531C4 Neosartorya fischeri
50937
MDAFQSVAFDFGRRGIVNPFVGALWAALIVWYLLTYLISPLRRFPGPILA (1) 51086
51149
GWTNLWRMYHVRKGKVHILTTELHKKYGPVVRIAPNVVDLDMPEMIRTIYSTRGDYRKTE 51328
51329
FYHGSSAKSNGKIIYNLFSECDPQVHALQKRPIAKYYSMSGVLPLEPHIDETIGFLCRRL 51508
51509
EEEFIDGPKAGRPCDLGQWLLY (1)
51633
YTWDVVGKVTFSEPIGYLEKGYDFDHTIAIADKAMDYFALVSQLPILDHLLDKNPIYRIGP 51815
51816
PSFGTVTNISIQHLVDRLQGRDTAYHDPSKPDFLDKFIEAKATFPHVVDDAQIISYLMIN 51995
51996
MIAGADTTAITLNAALYFALKNPAVWKRLQEETASLHCEGSPIVSFKTAQDLPYLNAVIR 52175
52176
EAMRMHPGVAMCLERYVPDEGLTLPGGQFIPGGCIVGMNPYVLARNQSVWGEDADVFRPE 52355
2356
RWLRDPTRETEEAYQERLKRMNAADLTFGAGSRVCIGRNLGMMEVYKVVATLVSRYEIEL 52535
52536
VDPKGEWKTHNSFFVRQEGIEVRLRRRST*
52625
>CYP531C4 Neosartorya fischeri
72% to CYP531C3
NFIA_055060
94% to CYP531C4 Aspergillus fumigatus
MDAFQSVAFDYGRRGLVNPFFGALWAALIVWYLGTYLISPLRRFPGPILAGWTNLWRIYHVRKGKVHIVTTELHKKYGPV
VRIAPNVVDLDMPELIRTIYSTRGDYRKTEFYHGSSAKNNGKIIYNLFSECDPQVHAQQKRPIAKHYSMSGVLPLEPHVD
ETIGFLCRRLEEEFIDGPKAGRLCDIGQWLLYYTWDVVGKVTFSEPIGYLEKGYDFDHTIAISDKAMDYFALVSQLPILD
HLLDKNPVYRIGPPSFGTITNISIQHLVDRLQGKDTAYHDPSKPDFLDKFIEAKATFPNVVDDAQIISYLMINMIAGADT
TAITLNAALYFALKNPAVWKRLQEETSSLHSEGSTIVPFKTAQDLPYLNAVIREAMRMHPGVAMCLERYVPDEGLTLPDG
QFIPGGCIVGMNPYVLARNQSVWGEDADFFRPERWLRDPTRETEEAYQERLRRMNAADLTFGAGSRVCIGRNLGMMEVYK
VVATLVSRYEVELADSKGEWKTHNSFFVRQEGIEVRLRRRSI*
>CYP531C5 Aspergillus terreus
65% to CYP531C4 Neosartorya fischeri
ATEG_06454.1
MTQQIYMDSIMNWCFHMGSLIAWACVFAVPIWYLTAYLISPLRQFPGPVLAGWTNLWRMYHVRKGNIHVVVHNLHKKYGP
VVRIAPGVLDLDLPDLVRTIYNAKGDFRKTEFYHVSSTKTNGKIIYNLFSERSPEQHLRQKRPIAKYYAMTEVLTLEPHV
NEMIQCLCQRLEEEFVAKPKSGSVCDLSEWMRYYTWDVVGKATFSNPFGYLQKGCDFDNTISIADQAMDYFALVAQLPVL
DYVLDKNPVYRIGPPSFGNITAISIQQLMSRLQRREAGTSQGASQDFLDRFIDAAAHDSDTIDHGQIISWLMINMIAGAD
TTASTLNAVLYYSLKHPAVWARLQQEIAMQEVEQDATACVLPFKSAHDVSYLEAVIREAMRMLPSVAMTLERYVPEGGLV
LPDGRRIPGGCAVGMNPYILARNSSVWGECPDEFRPERWLRDTAHESEAEYQERLQRMNNTDLVFGGGSRVCLGKNFALV
QIYKVLATLVSRYDIELASPDREWSTYNSFFIRQSGLYVRMSRRSK*
>CYP531D1 Fusarium graminearum FG09351.1
AACM01000383 FGcontig1.383_scaffold6
MALFTLSLGYLMYAGVAFVIARVLYEFFLSPLRHIPGPGPSKYTDFYRAY
LTTKGHVDSHTRAWHRKWGAAVRVGPNTVSISDPDLIKVIYTTRNPWRKT
NMYRPNDVLVNGQRIQNIFNTQDEDFHLKYTKPIRGFWTLPKMLEAEPLM
DETLCELITHLDNRFASTGDVCKMDDWVSYYAWDAAANISFGRTYGFMDK
GGDVEDIIAESTAGLKYFAPVSQIPWLDEWLDKNPIHRVGPRPLVNGVIY
TIKILTEYQQQLASGAAKRKPVDLFIDKYNSLKETVDYVDDQQVINWLML
NVLAGGDSTAGAMRAPAYHLLKNPSVCEKMVAELRSANLTLPVPQWKEIS
QLPYFDAVMRESMRISPAVGLILEREVPKEGLELPDGRFIPSGAKIGINP
CVVTRDVGVFGEDVDVFRPERWLRGKGETEEGHASRVRRMHECTELMFGH
GSRVCMGKYMSKLEMYKMFATLYVNFDVRITDPSHTWKYENNWFMYHRDI
PCKISRREKA*
>CYP531D2 Aspergillus nidulans AN5665.1 52%
to 531D1 53 clan looks intact
MTGVLLAGANASLWMQIPVVFAVLLLSKLIWDAFFSSLRVFDGPLPAKFT
DIWRAWQAFDGHIDRTYTKLHRKYGSVMRIGPNALSISDPSMIRVIYSTR
NPWKKSEAYRPNDVVLNGQRVSNLFNTQDEKWHNQNILPIRHLWQMTKVL
EYEPLIDKTLNKFVDKLAARFGGGEVCPADEWIGYFAWDVTANFSFGRHY
GFIDQEKDVDNLITDSTKGLIYFAPVSQIPWIDHLLDKNPIVRIGPKPTL
TGVLYAFKVVAEYQAQLNSNKVKPGNVDHTLDKYVQLKKTHPDVVNDVQI
VNWLMLSILAGGDTSSATMRATVYYLAKNADAYKKLVAELTTANLTMPAQ
WKDIRELPYLDAVIRESMRINPGIAMNFERVAPEGGYTLPDGRYIPAGTK
VGINPAVTNRDYAIFGEDSDSFRPDRWLKRDGESDEEYQERHKRMHDTCD
FVFGAGARVCMGRYLAMLEIKKLIATLYSTFDLHLVDPKHEWTYRNAWFV
YQQNMPMIITRRKLSA*
>CYP531D3 Nectria haematococca
e_gw1.20.308.1
Necha1/scaffold_20:255173-256867
76% to 531D1, 50% to e_gw1.3.1764.1
MALLTISFTYVLYGGVALIVARVLYEFLLSPLKHIPGPILAKFTDFYRAGLTTQGHVDSTTRGWHKKWGS
AVRVGPNAISISDPDLIRVIYTTKNPWRK (0)
SNMYRPNDVVINGQRIQNIFNTADKNFHAKYTKPIGGFWTL
TKILDLEPVMDETLGELVGHLDRRFANTGDVCKMDDWVAYYAWDAAANISFGRHYSFMEEGGDVGGIIAE
STAGLKYFAPVSQIPWLDEWLDKNPVWRIGPRPLVNGFVYTVKILTEYQQQVASGAAKRKPVDLFIDKYN
GLKDTHDFVDDNQVINWLMLNVLAGGDSTAGAMRSVAYHVVKDPAVYKKLIAEIESANLSLPVPQWKEIS
QLTYFDAVMRESMRIAPAVGLMLEREVPEGGFELPDGRFIPANTKVGINPCVVTRDTGVFGDDVDTFRPE
RWLRKDDETEDEYAHRFRRMHECTDLMFGHGTRVCMGKHMAKIEMYKLFATLYANYD
(0)
VRLTSPDHEWKYHNSWFMYHSDIPCILTPSQRT*
>CYP531D4 Nectria haematococca
e_gw1.3.1764.1
Necha1/scaffold_3:3276976-3278701
53% to 531D2, 38% to
fgenesh1_pg.scaffold_15000295
MAFTQLEYAHLLGIGAVLLCLAVVWQLLLSPLRAFPGPFVARFTDLWRAAAVLPGQIDNVNRRWHKRYGS
AVRVGPNTIILNGPEMIKIVYSTKKAWVK (0)
SDMYMINDVLLNGKRLANIFNTRDLEWHAQQIKPISKFFSM
SRLMDIEPLLDVTINMLTSKLNEKFVDGPSKGKVCMMDDWLGW (1)
LAWDSMANVTFGRHYGFIEKEQDVDGLIKDSVNSMRYFAP (0)
VCQIPWLDYLLDKNPIKRIGPKPQLTGTMYAVRAISEYKQEIAEKGLKSQNVPHLLD
KYLGLEEQYPGMVNDAQLVNWLLPTVIAGGDTTASAMRAVVYFLAKNPETKQKLFLELDQANLETPAQWK
DLKELTYLDAVIREAMRVCPGIGLAPERVVPEGGHILPDGRFLPAGTKVGLNPAVTSRDTGVFGADSDSF
VPERWLRQDGEAEDAFNQRFRRMHEVLDFVFGGGTRVCLGKNLAKLEIYKAIATLYSLYD
(0)
INLVDPRHEWKHYSCWFVYQLDIPTAISRRT*
>CYP531D5 Fusarium oxysporum
86% to CYP531D1 Fusarium graminearum
FOXG_05863
MALSSFDLSYVLYVGVAFVVARIFYDLLFSPLRRIPGPLAAKYTDFYRAFLATKGNVDGHMREWHQKWGSAVRVGPNTIS
ISDPDLIRVIYTTRNPWRKTNMYRPNDVVVNGQRMQNIFNTADEDFHTKYTKPIRGFWTLPKMLEAEPIMDETLCELITH
LDNRFASTGYVCKMDEWVAYYAWDAAANISFGRNYGFMDQAADVENIIAESTAGLKYFTPVSQIPWLDEWLDKNPIWRIG
PRPLVNGVLYTVKILTEYQQQVASGAAKRKPVDLFIDKYNSLKETVDYVDDQQILNWLMLNVLAGGDSTAGAMRAPAYHL
LKNPSVCEKMVAELRSANLTLPVPQWKEISQLPYFDAVMRESMRISPAVGLILEREVPKEGLELSDGRFIPAGTKVGINP
CVITRDVGVFGEDVDTFRPERWLRSKGESEQGHAHRVRRMHECTEMMFGHGSRVCMGKHMSKLEMYKMFATLYVNFDVRI
TDPNHRWKYDNSWFMYHKDIPCTISRRQKS*
>CYP531D5 Fusarium verticillioides
98% to CYP531D5 Fusarium oxysporum = ortholog
FVEG_03740
MDLSSFDLSYVLYVGVAFVVARIFYDLLFSPLRRIPGPLAAKYTDFYRAYLATKGNV
DGHMRAWHRRWGSAVRVGPNTISISDPDLIRVIYTTRNPWRKT
NMYRPNDVVVNGQRMQNIFNTADEDFHTKYTKPIRGFWTLPKMLEAEPI
MDETLCELITHLDNRFASTGYVCKMDEWVAYYAWDAAANISFGRNYGFMDQ
AADVENIIAESTAGLKYFTPVSQIPWLDEWLDKNPIWRIGPRPLVNGVLYT
IKILTEYQQQVASGAAKRKPVDLFIDKYNSLKETVDYVDDQQILNWLML
NVLAGGDSTAGAMRAPAYHLLKNPSVCEKMVAELRSANLTLPVPQWKEIS
QLPYFDAVMRESMRISPAVGLILEREVPKEGLELSDGRFIPAGTKVGINP
CVITRDVGVFGEDVDTFRPERWLRSKGESEQGHAQRVRRMHECTEMMFGHG
SRVCMGKHMSKLEMYKMFATLYVNFDVRITDPNHRWKYDNSWFMYHKDI
PCTISRRQMS*
>CYP531D6 Aspergillus clavatus
72% to 531D2
ACLA_059870
MTVLTYLLPTSWWGFIPVVVGVFVLTRAVWDALLSPLSAFPGPLAAKVTDFWRAAQAYGGYIDRKYNVLHRKHGSVVRIG
PNALSIGDPNLIRVIYSTRNPWKKSDMYKPNDVLINGHRMSNLFNTQDEHWHNQNILPIRPLWGMGKVLEYESLIDETLN
LFTGKLRARFTGSNGRTICPIDEWLGYFAWDVTANISFGRHYGFIEQEKDVDNLITDSTKGLIYFAPVSQIPWVDRLLDK
NPIVRIGPKPTLTGVLYTFGVVTEYQTQLKEKKSRLNAVAHTLDKYVQLKDSYPDIVDDNQIVNWLMLSILAGGDTTSAT
MRAVVYFLMKTPAANRKLAAELDAAKLDIPAQWRDIRELPYLDAVIRESMRLNPGIAMNFERIVPAEGFTLPDGRFIPGG
TTVGINPAVTNRDPGVFGGDVDVFRPERWLRGAGEDQAQFQARHRRMKDTCDFVFGGGGRICMGRYLAMLEIYKLIATLY
SQFEIQLVDPNHEWKYRNAWFVYQSDMPVIIRPRQRD*
>CYP531E1 Aspergillus oryzae
BAE63827.1
45% to
531D2, 40% to 531D1, 39% to 531C1, 40% to 531A1
44% to
531D4, 42% to 531D3, 38% to 531C2, 37% to 531B1
MLSITELIMDLGLAIVILGVSHLLWNYLSSPLKAFPGPLWASFTNLWRLQDVFKGRCDITHNQLHRKYGT
AVRMGPKVLSLSDPSVIPHVFNSKNPWMKSDMYNVNDVIVSGVRLKNLFSHQDEKWHSTYIRPVKGLYSM
TKVQDMEPGVDVTINLFMDKLRERFVEKGQLCDMADYLNFFAWDVMSQITFSQNLGILEAGSDYQGFLGR
SNKSLDYFASISQMPILDLLLDKNPIVRLGPPTFVWANIFSLEQLQKRLSGGTPPSGHTDFLDKFLETKK
KYPDLVNDNTVVTYLLSNTLAGSDTTGSAMCSAVYHILKHPRVHRKLREELYAAKVPLPAKWKDLQGLTY
LDAVMRESMRVNPGVGLMIERIVPEGGFTLPDGRFIPAGTIVGMNPWVINKNEAIFGANTEEFIPERWLP
SPGESDQAYQARFTKMKSTDFTFGAGPRMCMGRYLSQLESYKLIATLFSTFEMELPSLDHTWHVTNSWFV
RHKSIPVKMRERTDLAVSV
>CYP531E1 Aspergillus flavus
99% to CYP531E1 Aspergillus oryzae
AFL2G_10670
MLSITELIMDLGLAIVILGVSHLLWNYLSSPLKAFPGPLWASFTNLWRLQDVFKGRCDITHNQLHRKYGT
AVRMGPKVLSLSDPSVIPHVFNSKNPWMK SDMYNVNDVIVSGVRLKNLFSHQDEKWHSTYIRPVKGLYSM
TKVQDMEPGVDVTIKLFMDKLRERFVEKGQLCDMADYLNFF AWDVMSQITFSQNLGILEAGSDYQGFLGR
SNKSLDYFASISQMPILDLLLDKNPIVRLGPPTFVWANIFSLEQLQKRLSGGTPPSGHTDFLDKFLETKK
KYPDLVNDNTVVTYLLSNTLAGSDTTGSAMCSAVYHILKHPRVHRKLREELYAAKVPLPAKWKDLQGLTY
LDAVMRESMRVNPGVGLMIERIVPEGGFTLPDGRFIPAGTIVGMNPWVINKNEAIFGANTEEFIPERWLP
SPGESDQAYQARFTKMKSTDFTFGAGPRMCMGRYLSQLESYKLIATLFSTFEMELPSLDHTWHVTNSWFV
RHESIPVKMRERTDLAVSV
>CYP531E2 Aspergillus oryzae
BAE59053.1
52% TO
531E1, 40% to 531D2
60% to 531E1
after making adjustments for gaps
revised
3/19/2009
MDIAFKLVLLGATLILSHLIWNYFRSPLKSFPGPFSANLSNLWRLQDVFKGLCDITHNELHRRYRSAVCI
GPNVLSLSDPALINQVYSTRDPWVKVSSERTQDPQHSDVYNVNDSVVSGVRIKNLFSHQDEQWHANQELE
PGVDITINLFLE
SEYINY (1)
FTWDTMSQLSYSQSIGMLEAKNDRFGILEVSNRSLDYFAS
VCQIPMLDLLLDKNPICRLGPPSFGWSVKFSAEQYQERFTEGKQSHNGIKDFLDRYIETKSKMPNIVDDN
VAQMYLVLNIIAGSDTTARAISAAVYYEELRGANLSTPPQWKEIRSLPYLDAVMRETMLVHPGVGLLLERIV
PKGGFTLPDGRFVPEGTIVGMNPWVINRNRTVFGPEPDSFKPERWLPAEGEHDEAYQTRFSKMKGTDLTF
GAGPRACLGRYISQLESYKFVATLFTMFD (0)
LEHPDHEWEVTNSWFVRQKNIPV (0)
PSSSSSSLVVSL*
>CYP531E2 Aspergillus flavus
99% to CYP531E2 Aspergillus oryzae
AFL2G_04353
MDIAFKLVLLGATLILSHLIWNYFRSPLKSFPGPFSANLSNLWRLQDVFKGLCDITHNELHRRYRSAVCIGPNVLSLSDP
ALINQVYSTRDPWVKVSSERTQDPQH (0)
SDVYNVNDSVVSGVRIKNLFSHQDEQWHAN (2)
QELEPGVDITINLFLE
SEYINY (1)
FTWDTMSQLSYSQSIGMLEAKNDRFGILEVSNRSLDYFAS ()
VCQIPMLDLLLDKNPICRLGPPSFGWSVKFSAEQYQERFTEGKQSHNGIKDFLDRYIETKSKMPNIVDDN
VAQMYLVLNIIAGSDTTARAISAAVYY
EELRGANLSTPPQWKE
IRSLPYLDAVMRETMLVHPGVGLLLERIVPKGGFTLPDGRFVPEGTIVGMNPWVINRNRTVFGPEPDSFKPERWLPAEGE
HDEAYQTRFSKMKGTDLTFGAGPRACLGRYISQLESYKFVATLFTMFD
(0)
LEHPDHEWEVTNSWFVRQKNIPV (0)
PSSSSSSLVVSL*
>CYP531F1
XM_001227270.1 Chaetomium
globosum CBS 148.51 revised C-term
53% to CYP531A2 add to nomen
MASASPAANGGIPPAEGFTLDLTTLLAGVWGNKLSALVLGPSVA
VFLWFFVAYQTSPLKKYPGPFLAGWTNLWRVWQVISGEYAPRMKKLHEKYGPIVRIGP
NLLDLDIPELYRVIYGTDGKWIKSDFYKNSSSIIDGKITYHMFSEVDPTLHALIKRPV
VRHYSVPAVLVMEPLMDTIIKEFIDTLQKRYVEPKKTCEFGEWLSYYAWDFMGMVTFS
TKFGYMEKGTDFDGTLAIADKSIDYLALCGQMPWTDYILDKNPIYPIGPPNIGNVTRI
AVQNLTARLKGEDKNFTEGNPDFLQYFIESKSTHPELVNDG
(seq gap)
SRLQRDVRANFAAFEPA
AHSKARALPYLEAVVKETLRYHPAVSMIMERIVPEGGLTLPDGSVVPAGQMVGMNPYI
VGRNKEVFGEDAEEFNPDRWLRREGEGEEEHKERMARWGQSLLAFGGGYRICLGRNLS
MMEVYKVVPTLLASFDIELEDPNEVWWTCSRWFYRTKGVICKLKPRSS*
>CYP531F2 DV545173.1 Chaetomium
cupreum EST
86% to XM_001227270.1
Chaetomium globosum
LSMMEVYKVVPTLLAAFDVELVDPEEKWWTCSRWFYRTKGVICRLKPRST*
>CYP532A1 N.
crassa AABX01000767.1 cont3.215 NCU04089.1 (version3)
33962
MITDLIIKVLAQHWPAILCLVLVGWLVRNRYHNGLNKYPGPFLA
SLTDWWRFIDVYKRRPEVTHIALHKKHGPIVRLGPNTLSFSDPE
AIKTIYGLNKGFVK
(0) 33657
33584 SDFYVVQQSTVKGHNLPSLFSTTDNEFHMQFRRCVNSAFAMSAL
VQYEPFVDNTTKLFLEQTEKLYVEGGEKACDFTRWLQFYAFDVI
GEITYSKRHGFIEHNKDIDGIVSYLTKLFNYVAP (0) 33219
33153
IGQIPLLDRLFLKNPLYLKLSQWGLIDGTMPVAAFARARMAERL
PELQTEKTAILPTSEKQAQLKIQTPDLLSKFLAARSARPNFMTD
TLVQTMAVSMAFAGSETTAISLSAVFYYLLRTPRALARLREEID
EAARQGKFSDYETGLVTWAEAQTLPYLDACVKEAFRLHPAPGLP
MERVVPPQGMEIVPGQFVKGGTIVGVSAWVLHRDESIFGERVEE
FRPERWFVDETVAKEDMEGKKREEEEKRIKTMNGHMLQFGMGSR
TCIGKNISLLEIYKLVPTLLRRFE (0) 32290
32200
IEFDDPSREWEIVNAWFVKQNNFITRFKVRDIVMPENKEY (2) 32081
32012 KFDGRGVN*
31986
>CYP532A2 Magnaporthe grisea MG07795.4 65% to CYP532A1
AACU01000949 cont2.1444
MQGLTAPILHFLAANWLPVLVAVTAAWLARNRFQKGLHKYPGPFLASLTD
FWRVWDVYKQRPEVTHRKLHERYGDVVRLGPNALSFSDPKALKAIYGLNK
NMVKSDFYIVQQSVVKGRRLPSLFSTVDESFHAKFRRCVNAAFAMSALVQ
YEPFVDNTTKLFLDQTQRLFADKPAGDDSGCDFGRWLQFYAFDVIGEITY
SKRHGFVEKNEDIDGIVSYLSKLFLYVAPVGQMPLLDLLFLKNPVYLKLS
QWGLFDSTFPVAKFARARMAERLPAGGSMNGGFGAGADEKPAAEPHPSTK
SPDLLSKFLAAQEARPDFMDDSLVQTMAVSMAFAGSETTAISLSAVFYYL
LRNPSAMARLRREIDDAARRGEFEDGETGLVTWHESQRLPYLDACVKEAF
RVHPAAGLPLERIVPEGGMEIAGHFVPGGTIVGVSAWVIHNNKDIFGEDV
DVYRPERWLVDEELVKAAGPAGHEVRAREEQRIKEMGGMMMQFGMGSRTC
IGKNISLLEIYKLVPSLLRRFDIDFKDPQQEWELVNAWFVKQNNFWAKFK
TRELVQPDEKSGAIAR*
>CYP532A3 Fusarium graminearum FG01745.1
AACM01000092 FGcontig1.92_scaffold1
MHGGLIETLLSVLAQHWVLALTTVTFAWLVRNRFHHGLNKYPGPFLASIT
DWWRFFDVYGQKSEATLRKLHAKHGDIVRLGPNNLSFSDPSVLKQIYGLS
KGYVKSDFYIVQQSVVQGHRLASLFSTTDNDFHSQFRRSVNAAFSMSALV
QYEPFVDNTTKLFLDQTEKLFAKKSEVCDFTQWLQFYAFDVIGEITYSKR
HGFIEKNEDVEGIVAYLSKLFLYVAPIGQIPFLDLLFLKNPIYLKLSQWG
LFDSTFPVAKFARARMAERLIPELHASDGLPTSNIKKQPLGQDLLSKFIA
AREARPDFMTDTLVQTMAVSMAFAGSETTAISLSSVFYYLLRNPACYEKL
KKELDDAAKAGVFSDYETGLVTFTEAQKFPYLHACVQEAFRVHPAPGLPL
ERIVPPQGAEINGEFIKGGTVVGVSAWLIHHRQEIFGPDTDAYRPERWLP
DPKLNPEDEDKRIKKMTGMMFQFGMGSRTCIGKNISLLEIYKVVPSLLRR
FEISFDDPTKEWKTINAWFIKQTDFNVRFTKRELVQPEFSEK*
>CYP532A4 Aspergillus nidulans AN2125.1 56%
to 532A3 top part
revised 7/18/07
MALVTEILDHTEPLSNYGLYILPFFILLYLAQQYFHNGLHRYHGPILAKF
TNLWRFLDVRGRRPELTHIALHRKYGDVVRLGPNTLSFASPSAIKVIYGL
NKGFTKANKSQSEFYPVQMTVSKGEPLPSLFSTLDESFHANLRRSVNHAF
SMSSLVQYEPMVNQTVELFLDQTAALFANSGKTCDFARWLQFFAFDVIGS
ITYSKRHGFIEKNEDIDGILKSLARIFDYAGPVGQMPWLDKWLWKNPIYD
VLQRWGIADNSHPVAIFARQRMNERLMADNGTRTEAEQQQDLLTKFIQAG
KDRKDFMTEKRVLTMAVSMAFAGSETTAISLAAVFYYLLKNPEYMARLRG
ELDNAVAHGIVENRSSGLVTWSESQKLPFLDACIKEAFRIHPAAGLSLER
VVPASGIDIAGHFIPGGTIVGCSAWVLHRREEIFGPDVDSFIPDRWLNVS
AERLKTMNGTMLQFGAGARTCIGKNISLMEIYKLVPSFLRRFDIQLAHAD
QEWELWNAWFVRQYNFKTKFTARNFEV
>CYP532A5 Nectria haematococca
fgenesh1_pg.scaffold_1001305 NEW
Necha1/scaffold_1:4090277-4092053
83% to 532A3
This gene model seems correct
MNNGLIETLLSNLARHWVLVLVSLVLGWLVKNRYHHGLNKYPGPFLASLTDWWRFVDVYGQRPEVTLQAL
HAKHGDIVRIGPNTLSFADPAVLKSIYGLNKGYIK (0)
SDFYIVQQSVVKGHRLASLFSTTNNDFHSQFRRSVNSAFSMSALVQYEPFVDNTTKLFLNQTEKLFAGKP
EGCDFTQWLQFYAFDVIGEITYSKRHGFIEKNEDVEGIVAYLSKLFLYVAP
(0)
IGQIPFLDLVFLKNPIYLKLSQWGLFDSTFPVAKFARARMAERLIPELNSDAVL
PTTDIKKQALGQDLLSKFIAAREARPEFMTDTLVQTMAVSMAFAGSETTAITLSAVFYYLLRNKSSYYKL
QKELDEASKAGAFSDYETGLVTFAEAQRFPYLHACIQEAFRMHPAPGLPLERIVPPQGAEIGGHHIKGGT
IVGASAWLIHNRPEIFGDDTSEYRPERWLPDPNANPEDEDKRIKKMSGMMFQFGMGSRTCIGKNISLLEIYKVVPSLLRRFE
(0)
IDFQDPSKEWRIINAWFVKQADFNVTFTRRQLVQPEITEKAG*
>CYP532A6 Aspergillus oryzae
GenEMBL
BAE66552.1
74% to 532A4
MTLLAEVFSRASPEYALYILPFISLIYIGHLYFHNGLNRYPGPFLAKFTDLWRFLDVWGRQPHETHIALH
RKHGDVVRIGPNTLSFSSPAATKVIYGLNKGFTKSEFYPVQMTVSKGEPLPSLFSTLDDKFHAELRRSVN
HAFSMSSLVQYEPMVDETTLLFLDQTDRLFATGGKVCDFARWLQFFAFDVIGSITYSKRHGFIEKNEDID
GIVKSLARIFNYAGPVGQMPWLDKVFWKNPIFDAMQKWGLLDNSHPVAIFARQRMMERMSSKAAIDPSSR
SDLLTKFMKAGELRPNFMTEKRVLTMAVSMAFAGSETTAISLAAVFYYLLKTPDYMRRVREELDEAIQNG
TIENRPSGLVSWTESQKLPFLDACIKEAFRIFPAAGLPLERVTPPSGADIAGQFIPGGTIVGCSPWVIHR
REDIFGSDVDTYNPDRWLNASEDKLKIMNGMMLQFGAGSRTCIGKNISLMEIYKLIPSFLRRFDVRLAYP
EQEWRLWNAWFVRQYNFNTVFTPRKIEVQ
>CYP532A6 Aspergillus flavus
100% to CYP532A6 Aspergillus oryzae
AFL2G_11872
MTLLAEVFSRASPEYALYILPFISLIYIGHLYFHNGLNRYPGPFLAKFTDLWRFLDVWGRQPHETHIALHRKHGDVVRIG
PNTLSFSSPAATKVIYGLNKGFTKSEFYPVQMTVSKGEPLPSLFSTLDDKFHAELRRSVNHAFSMSSLVQYEPMVDETTL
LFLDQTDRLFATGGKVCDFARWLQFFAFDVIGSITYSKRHGFIEKNEDIDGIVKSLARIFNYAGPVGQMPWLDKVFWKNP
IFDAMQKWGLLDNSHPVAIFARQRMMERMSSKAAIDPSSRSDLLTKFMKAGELRPNFMTEKRVLTMAVSMAFAGSETTAI
SLAAVFYYLLKTPDYMRRVREELDEAIQNGTIENRPSGLVSWTESQKLPFLDACIKEAFRIFPAAGLPLERVTPPSGADI
AGQFIPGGTIVGCSPWVIHRREDIFGSDVDTYNPDRWLNASEDKLKIMNGMMLQFGAGSRTCIGKNISLMEIYKLIPSFL
RRFDVRLAYPEQEWRLWNAWFVRQYNFNTVFTPRKIEVQ*
>CYP532A7 Mgr043 Mycosphaerella graminicola
55% to CYP532A2 Magnaporthe grisea
MLIDEVLLPILLDYWPLIVVATTAIHLLRNKYHNGLNQYPAAHPLASYTDWWRYFDVSKRRAQHTHLDAHSKHGDIVRLGPNVLSFSDPKAIKIIYGLNKGMTKSDFYPVQRAVAGGRALPSLFATKDEGYHARYRRCINSAFSMSSLIEYEPLVDSTMNVFIEQTKRRYCDTGLTCKFSQWLQFYAFDVIGELTWSKRLGFVERAEDVDNIVSFVSGFLDYCAPVGQMPWLDFVWEKNPLRLLLQRWGVSKTVFPVTKFALARSAERGSEMDKIRQHGAVEKSTKGIDLLTKFTLAQHDHPDFMTDKQVLASCTSMIFAGSETTAISLSSIFTHLLQNPRAYAALMAELDAATLAGTIEPRSNNRVSWSESQKLPYLDAVIQESFRLHPAPGLILERVVPASGMDILGTHVPGGTIVGCNAWVLHRRPEVFGADVNAFRPERWLEAKPDQLREMKASMFQFGAGARTCIGKNISLLEMYKLVPTFLRNFEVTLEDRVKTTNAWFVRMEFHARFKPRDQATGA
>CYP532A8 Fusarium oxysporum
85% to CYP532A3
FOXG_10880
MHSGLVETLLSALAQHWVLVLTSLTVAWLVKNRYHHGLNKYPGPFLASLTDWWRFWDVYGQRPEVTLQKLHAKHGDIVRL
GPNTLSFADPAVLKSIYGLSKGYVKSDFYIVQQSVVKGHRLASLFSTTDNDFHSQFRRCVNSAFSMSALVQYEPFVDNTT
KLFLEQTEKLFAKRADVCDFTQWLQFYAFDVIGEITYSKRHGFIEKNEDVEGIVAYLGKLFLYVAPVGQIPFLDLIFQKN
PIYLKLSQWGLFDSTIAVARFARARMAERLIPELKSVDSLPTSNLKKQPLGQDLLSKFIAAREARPEFMTDTLVQTMAVS
MAFAGSETTAITLSAVFYYLLRNPECYQKLKNELDEAAKAGVFSDYESGLVTFSEAQKFPYLHACVQEAFRMHPAPGLPL
ERIVPPQGAEIGGEFIKGGTIVGVSAWIIHNRPEIFGTDTDKYRPERWLPDPNLDAEEEDKRIKKMTGMMFQFGMGSRTC
IGKNISLLEIYKVVPSLLRRFEINFEDPSKEWRIINAWFVKQTDFNVKFTRRELVQPEFSEKQE*
>CYP532A8 Fusarium verticillioides
98% to CYP532A8 Fusarium oxysporum
FVEG_09894
MHSGLVETLLSALAQHWVLVLTSLTVAWLVKNRYHHGLNKYPGPFLASLTDWWRF
WDVYGQRPEVTLQKLHAKHGDIVRLGPNVLSFADPAVLKSIYGLS
KGYVKSDFYIVQQSVVKGHRLASLFSTTDNDFHSQFRRCVNSAFSMSALV
QYEPFVDNTTKLFLEQTEKLFAKRADVCDFTQWLQFYAFDVIGEITYSKR
HGFIEKNEDVEGIVAYLGKLFLYVAPVGQIPFLDLIFQKNPIYLKLSQWGL
FDSTIAVARFARARMAERLIPELKSVDSLPISNLKKQPLGQDLLSKFIA
ARESRPEFMTDTLVQTMAVSMAFAGSETTAITLSAVFYYLLRNPECYQKLK
NELDEAAKAGVFSDYETGLVTFAEAQKFPYLHACVQEAFRMHPAPGLPL
ERIVPPQGAEIGGEFIKGGTIVGVSAWIIHNRPEIFGNDTHVYRPERWLPDP
NLDAEEEDKRIKKMTGMMFQFGMGSRTCIGKNISLLEIYKVVPSLLRR
FEINFEDPSKEWRIINAWFVKQTDFNVKFTRRELVQPEFSEKQE*
>CYP532A9 Mycosphaerella fijiensis
70% to CYP532A7 Mycosphaerella
graminicola
fgenesh1_pg.C_scaffold_1001379
MLAGELLKALINYWHIVLVALLAAHLASNKYYKGLNKYPGPRLAAFTNWWRYFDVLSRKAERTHLDLHRKHGDIVRLGPN
VLSFADPRAIKIIYGLNKGFTKSDFYIVQQAVAKGERLQSLFSTKDEDYHAKYRRCVSNAFSMSSLVGYEPLVDSALNAF
IEQTRRRYCDTGRSCKFSRWLQFFAFDVIGELTWSKQLGFVQRDEDVEGIVKFVADFLKYAAPVGQMPFLDLIWEKNPLR
LKLQQLGFIKTEFPVSRFALAQNATRAAEIEKIKQGAALDDRSGKGIDFLMRFTQAQHDHPEFMTDKQVLASCNSMIFAG
SETTSISLSSVFYHLIKHPRVYQKLMSELDDAAVNGTITEKNYGKVSWSEAQKLPYLDAVIQESFRMHPAPGLILERVVP
PQGMDILGERIPGGTIVGCNAWVLHRRPEIFGPDVDVFRPERWLEARPEQLREMKATMFQFGAGARTCIGKNISLLEIYK
LVPTFLRNFEVEMAGEEDAEWKTCNAWFITQDFDTKFRPRRIAQSA*
>CYP532B-532G # renamed CYP5080A, CYP5078A,
CYP5080D, CYP5077A,
CYP5080B, CYP5080C
>CYP532H1 Nectria haematococca
fgenesh1_pg.scaffold_58000031
Necha1/scaffold_58:68174-69912
46% to 532A2 with two small deletions compared
to 532A2
These deletions are not seen in AP007175.1
Aspergillus oryzae
This gene model seems correct
MILELLIPHSFGVAILWLLAGILLRLLVNKYGQGLNKIPGPWLAGFTDLWRLFIVRGRRAQEVHIELHKK
YGPMVRLGPRAVSVADPEAIKIIYSPSSGYSK (0)
SGFYPVQQALAKGNRLETMFNTANDSYHARLRRSVSNA
YAMSTLVAFEPFVDSTSTEFLKQLKLRFADRPGDEGICDFGAWLQYYAFDVIGELTFSKRLGFVETGRDV
DNIIRDLEGFLNYVSW (0)
IGQIPFLDRLFIKNPIKIWMAKNGLLNSSAPVAEFAKKHVVERQREEESGNSKT
PRRDFLNRFKEARAKDPEFITEQLVLALTVANMFAGSDTTGITMRAVFYYLLRDPSKMDKLLDELARESK
AGRFSREDGLAQWEEVRDLPYLSAVINEALRCHPAVGLTMERIVPPSGVTIAGHFLPGGTIAGCSAWVIH
QNAEVFGSDAADFRPERWIDATPEQRRRMNNCLFSFGAGARTCIGKNISLLELYKLVPTILRRFE
(0)
LELVNPETPWKLHNAWFVRQAGFNVRLKERDQII*
>CYP532H2 Nectria haematococca
Necha1/scaffold_12:138036-139715
e_gw1.12.581.1
55% to fgenesh1_pg.scaffold_58000031
This gene model seems correct
MFISSFISTHLDILAGLLVLSLLAKLVYNRYGHGISHIPGPFFASLSDLWRLYVVWGRRPDIDHVKLHER
YGKLVRLGPKAISISDPGAIRQIYGLAAGFQKSDFYTVQQTLARGRPLFTLFTSTDTRFHAKLRRSVSSA
YAMSTLVQFEPYVDSTTVELIRQIDERFKDKQESCDLGKWLQFYAFDVIGELTYSKRLGFVDRGVDVEGI
ISSIEWMLDYASV (0)
VGQMPIIDSFLLKNPIRLFLSRLGLIGSTTPMVKFARQRFSERVDLATGQEKPSSRM
DSSSTRRDFLSRFLEAHKKDPDFVTSERVLALTVANIFAGSDTTAISLRSVFYFLLKSSKELERLMAELE
EQKRTGKFKRTDGLVDWEEARDLPVLGAVIKEALRIHPAAGLTLERITPPQGVRISDKFIPGGTIIGCNA
WTIHRDASIFGSDPDRFRPLRWLEASPDQRRLMDNCLFSFGAGSRTCIGKNISLLEMYKLIPALLMRYK
(0)
LELPRENSDWKLHNAWFVKQSNFYVRFKTRGYSA*
>CYP532H3 Fusarium oxysporum
81% to CYP532H1
FOXG_10225
MILERIVPQSFSAAVLWLIGVILTRLIYNKYGHGLNHVPGPWLAGFTDLWRLLVVRGRR
AQEVHIELHKKYGPAVRLGPRAVSIADTDALKVIYSPSAGWSK
(0)
FYPVQQALAKGKRLET
MFNTDNDRYHARLRRSVSNAYAMSTLVTFEPFVDSTSAEFIRQLKLRFSDQTGNAGICDFGAWLQFYAFDVIGELTF
SKR
LGFVEKGIDIDNIIRDLESFLNYVSW
IGQIPFLDKLFIKNPIKIWLVKYGFLNSSAPVAEFARKHLVERQHEEASDMPKA
PRRDFLNRFKEAHNKDPDFITEQLVLALTVANMFAGSDTT
GITLRAVFYYLLKDPPKMESLLKELAAESKAGRFSRDDGL
VQWEEVRDLPYLSAVINEALRCHPAVGLTLERIVPSGGVTLGGHFIPGGSIAGCSPWVIHQDAEVYGADAAEFRPERWIE
ATPEQRKKMNSCLLSFGAGARTCVGKNISLLELYKLVPTILRIFELELVNPDTPWKLHNAWFVRQMGFNVRLKERKTIL*
>CYP532H3P Fusarium verticillioides
90% to CYP532H3 Fusarium oxysporum
no gene model, missing C-term
MILEHIVPQSFKAAVPWLTGIILTRLMYNKYGYGLSHVPGPWFAGFTDLWRLLIVRGRRA
QEVHIELHKKYGPAVRLGPQAVSIADTDALKVIYSPRAGWSK ()
FYLVQQALAKGKRLKAIFNTDNDSYHARL*RSVSNAYAMSTLVTFEPFVDSTSAEFIR
QLKLRFSGNTSNAGICDFGALLQFYAFDVIGELTF &
SKRLGFVEKGVDIDNIIRDLEGFLNYVSW (0)
IGQIPFLDKLLIKNPIKIWLVKYGFL ()
NSSAPVAEFARKHLVERQLEEASDVPKAPKDFLNRFKEAHNKDPDFITEQLVLELTVANMFAGSDTTG
>CYP532H4 Fusarium oxysporum
60% to CYP532H1 Nectria haematococca
FOXG_16603, AAXH01001105
MILDLFLQHPWAYLTAAVVGLLVTKLLVNKYGNGLNGIPGPALASFTDLWRFLDVYRRRPEVTQIALHEKYGTVVRLGPN
TVSIADPAAIQTIYAHNSGYTKSDFYPVQQTINKSGKRLITLFTSQDEKFHSQLRRSVSNAYAMSTLVQFEPFVDSTTTE
FFKQLDQRYANQNDILDFGTWLQYYAFDVIGELTYSKRLGFVDHGKDVDNIIGNLEWLLNYAAPVGQLPILDSLLLKNPL
RLQLTKWGFTNSSSPVAIFARNRMLARVDPEKLGDMKFDQDNGRRDFLSRFLEANQKDPEFMNNDRVLALTVANMFAGSD
TTAITFRAIFYYLMKNPADMKTLMAELAEEEKAGRFAREDGLVSWNEVRDLPFLNAVVKEALRCHPAAGLMLERIVPARG
LEVNGHHISGGTIVGVNAWVLHRNKDIFGHDADRWRPSRWIEASTEQKRRMENYMFAFGAGSRTCIGKNISLLEMYKMVP
ALLRRYE (0)
LEFPSADNTWHLNN (1)
AWFVKQSNFNVRLRRKHKLSFLPDERQD*
>CYP532H4 Fusarium verticillioides
97% to CYP532H4 Fusarium oxysporum
FVEG_13640, AAIM02000185.1
MPCVSPVQQTINKSGKRLITLFTSQDERFHSQLRRSVSNAYAMSTLVQF
EPFVDSTTTEFFKQLDQRYANQNDILDFGTWLQYYAFDVIGELTYSKRLGF
VDHGKDVDNIIGNLEWLLNYAAPVGQLPILDSLLLKNPLRLQLTKWGFTNS
SSPVAIFARNRMLARVDPEKLGDMKFNQDNGRRDFLSRFLEANQKDPEF
MNNDRVLALTVANMFAGSDTTAITFRAIFYYLMKNPDDMKTLMSELAEEEK
AGRFTREDGLVSWNEVRDLPFLNAVVKEALRCHPAAGLMLERIVPARGL
EVNGHHIPGGTIVGVNAWVLHRNKDIFGHDADQWRPSRWIEASTEQKRRM
ENYMFAFGAGSRTCIGKNISLLEMYKMVPALLRRYE (0)
LEFPSADNTWHLNN (1)
AWFVKQSNFNVRLRRKHKVSFLADERQY*
>CYP532J1 Nectria haematococca
fgenesh1_pg.scaffold_24000107
Necha1/scaffold_24:254874-256710
47% to fgenesh1_pg.scaffold_58000031
MAIITEITGLIREHLPVIAVVLVLVHLTRNYFTRGVSEVPGPFLARFSNLWRFIDVARGKAEETHLKLHQ
KYGQYVRLGPNLVSVQNLDALKVIYGVNKGYTK (0)
TKFYEPQQQLFNGNPTQTLFTTLDEDFHARIKRPISSAYSMSTLTEFEVFVDKTIHTMIGRLDEFARDGRVCDMAIWLQY
(1)
YAFDVIGELTFGKPLGFLEQGKDISNIMLSLERNLDYAGM (0)
VGQMPWLDHLIVKNPIRRLMGGSATGAIAKFARECLDERLERGDTKSEKPLRRDFLTRFLDAKVTHPQ
VVTDRQVFSYTLSNVNAGSDTTAISLRAVLYYLLKNPVIMDKVCKEIEHAHSEGKFSIPVTWKESQELPY
LDAVIKEALRLHPAVGLLLERIVPEGGLQLPDGPFLPAGAVVGINPWVMHHSPIFGEDLDSFIPERWLQV
ANETKQQYDSRKAEMLGATFTFGAGSRTCIGKNISLLEIYKAMPTLLYLFK
(0)
IELDEPEKEWETCNAWFVRQKHINVRLTRVR*
>CYP532J2 Aspergillus niger
e_gw1.2.1446.1|Aspni1
63% to CYP532J1
MALLTTTLTYLSQHIPSILFTILIIHLARNYFKPGLSRIPGPFFAKITNLWRFVDVARGRAEVTHYQLHQKHGEYVRLGP
NVVSVWNVEALKVIYGIKRGYKKTAFYRVQQQLVKGKPTRTLFTTLDEDLHAKIKRPVSAAYSMSTVTEFEPFVDSTTQT
LFARLDELSEKGCVFDISTWLQYYAFDVIGEMTFSKQLGFLREGRDVEGIMESLEKMFDYAGKIGQMPWLDYVLIKNPLR
QLIRGGSTGAVARFARDRLHERLSQGGSKRDDIHERQKDFLTRFLEAKSIHPDVVDDAQVFSYTTSNVNAGSDTTAISLR
AILYYTLKNPRVFSKLQDELNGALQTGKVTIPVSWKQSQELPYLDAVIKEALRLHPAVGLLLERVVPAEGLQLPNGPFLP
AGTVVGVNPWIIHRHAIFGKEIDRFVPERWLRGNDESEAEFKMRRQNMLGATLTFGAGPRTCIGKNISLLEIYKLIPSLL
LAYKIELSEPEAEWEVVNAWFVRQ
>CYP532J3 Aspergillus terreus
72% to CYP532J2 Aspergillus niger
ATEG_04107.1
MAVLSSIYGFVSQHLLALTVLSIVYYLTRNYLTPGVSSVPGPFLAKLSNLWRFVDVARGRPEITQYKLHQKYGDYVRLGP
NVVSVRNPDVVKTIYGINKGYRKTDFYRVQQQLAKGKPTPTLFTTLDEDFHAAIKRPVSSAYSMSTLTEFEPFVDSTIRS
LFVKLDEFVASRKVCDIAIWLQYYAFDVIGHLTFSKPLGFLEHGKDVDGIIGSLEKTLDYAGKIGQMPWLDYVFVKNPLK
QLIQGGSTTAVARFARDRMSERLSQPSEKASAASSQQKDFLTRFLEAKKTYPETVTDAQVFSYTVSNMNAGSDTTAISLR
AILYYTLKTPQVKAKLMAELLDALHTGKLTLPVSWKQSQELPYLDAVVKEALRLHPAVGLLLERIVPAGGLQLPNGPFLP
PGTIVGINPWIIHRHAVFGSDVDSFVPERWLRGEDETEAAFQARRQDMLRATLTFGAGPRTCIGKNISLLEIYKLIPSLL
LTYEIELDDPTTEWEIINAWFVRQKKIDIRLGRRYLGEGRVGAQTGRQCDV
>CYP532K1 Mgr001 Mycosphaerella graminicola
45% to CYP532J1 Nectria haematococca (yellow part
omitted)
42% to 532A6, 45% TO 5077A1
Families CYP532 and CYP5077 overlap, cyan from
JGI model e_gw1.12.214.1|Mycgr3
MILTALYGAFEALIYGALPTILIIVVGGSIVLGYTT
LSDIPGPFYAKFTDYWRFRVVGKRNSHETYLKLHEEYGDFVRIGPNCVSISRPDVIPLIYGINVKATKSDFYTVWQNVVNGKRTASLVFTTDEAHHATMKRPIANAYSLSTLVEFEPLIDSTTAVFLSRLDSQFASTGAVCDLGTWLQWYAFDVIGELTLSKRLGFLEKGEDVENIAANVARNFDRCSSLGQMPWLDLIYKHPYFQALFLKSPVNPIIAFGQRRLQERLDDNEDTPPP
TDLGITDPSLAAKVLHTTL
PSKPDFLSRFLTLHETQPEIVTENTLLAYLFMNINAGSDTIASTVRALFYHLLRHPSTLTTLMTELDAAHEAGNLTLPLPTWSEVQPLPYLSAVVKESLRLNPALALPLERIVPAAGITINGTFFPPNTVIGVNPWVLHRDTRIFGSDAKEWNPSRWIDGDAERTRYMESHLLSFGAGKRTCLGRNIAILELSKVVPAILCRYKMRLEDEGREWKVVNSWAVRQEGLEVLLERR
>CYP533A1 N.
crassa AABX01000277.1 cont3.42 NCU01134.1 (version3)
41700
MLKFFMGDFDIGPLSNMVTSNSSATRASSAPANGFQFIQQSVDT
VAGTAIGLFIAYSAYKNLSEAYRRGDPNRKAPLPPSPPGDFLLG
HYRHVPENESFRKYLEWSKKY (1) 42026
42089
NSDVLYFETFGTKWVVLNSYEAAHELLEKRGRKYSDRPRFVMFEE (2) 42223
42284 MGWAPTLTWLRWGPQWGLHRKVLAPPFAKTGCVSFQPLQRKQAM
IMCKNLIENPEEWMSAVTHFAVAIMFKIGYGIDVDTPTDEWVKL
AAEASEAVGKAGAPASSIMDRIPWSKFLFLATI (0) 42646
42717
RLKYAHENKKVIQNITERPFNASMSDY (0) 42797
42850
HERDLDPTRKLKECFVHRMYHLRGEDARRNRQNVYYEEDIKGGA
ATMLIAGNDTTASTLNLIILYLTKHPRVQRRAQAEVDYILLTTG
VPTEPVEDYRPSTPAPWASSSSNRAGIIRLPTLEDIPKFKYVNL
ILQEVYRINPLSPLGIPHASVKDSSDIDPDGDDTYNGMRIPCGT
IVYPNVWAMNRDEKRYREPERFFPERYLPKEEGGWGEPLPVGNF
GFGRRVCVGQYLAENSLLIAIAMMLATIEFDLPIGPDGNLKDFE
PQFSHKGQS (2)
43668
43748
IVLPFKVSIKPRSPMVEELLDRHILVAKMAEKAAEDGKKGGPTPSA* 43888
>CYP533B1 Magnaporthe grisea AACU02000566.1
revised
MMTSTAGPYATTSLLNIGAVLVGLILVCKLASVVPSLRLGGWLSLVRR
RKLPLPPGPPRNFFLGHYRTVPFEAPFKKYAEWGKQY (1)
QSDVLFFSAFGRPWMVLNSLEAAVDLLEKRGHKYSDRPRFVLWEL
(2)
MGWAPTLTWLRWSPK
MLQHRRMLQPPFSRSRVGQFKPVQKREAVRAALCMVRDPEHWAKAATRFA
VGVVLDISYGIELKWTGSCNNNNPYVALLDDASTAIGNAGPPASSIVDRW
PLARHLPAWLPFMER
LRYARKWRSAIVQVTNFPF
SAALREMLSTSIEKTTKPSFVRERLDVFRRNQQAGVDNDFGMDDIKGSAA
TILIAGSDT (0)
TATTVRLFILYMMQNPRVQKRARTEIDRAIGTTTPTEMRRLPTWGDMNKLPYLAL
VLQEVYRSNPLSPLGIPHATLEDDEYRGMLIPKGTVVYPNAWAMAHDPLV
YSAPDEFLPERYMPRGSITIGQTKDDAAPGRGESLPIGNFGFGRRICVGR
TLAENSLLIVFATILATLEIGPPGGEDGQEDQDVQWSFRGQAYPLPFRCS
IVPRSDMAIRLLEDSAGVPEAT*
>CYP534A1 N.
crassa AABX01000272.1 cont3.221 NCU04234.1 (version3)
10018
MRLTPLVTLLGVFLAWATYKIYAGFRSNIAKARKTGYPVLIT (1) 9893
9782
PIYPLSPLWLTTRHFLLPILTRLLPERLYASYVFVMTPDWEY
HPSPRSHFTRLGSDTF
VVASWNGLACYTSDAAVISQVMSRREAFPKDTRQYGILEIFGSNVVTTEG
QVWRMHRKVTSASFNERNAGHTFREAVRQTRGMVGGWFSSSSSSSSSSSS
SGSQEEGTGRREGDVEDMTGIITTLEHDTMRWALNIIGYVGFGLKLLWPH
ESMPKDMDPKLAKYGSLQPPYGYSMTFADSLATVLERIVILLLIPSAVLK
RIPERWGSWGSKLHEAWEAKVNYSKYMNAFLAEKVQDIRAGVQEREGMNI
MGQLVRSKYDPSSSEKNDGATMKLEDSEIMGNAFIMTLAGHETTANVIHF
AIVELAMHPEVQRRVQRDIDAIFGRDSDPETWDYEKSINALLASYIGAVI
NETLRLIPPVVVTPKRVADTDQWVQDGGQRHPMPAMMPVMPVISAVQRSR
RYWPALHDKTTKKGDTDDLDEWHPDRWYLPSMSQGQPSSDDEKGEGKQQQ
EENYGGYQGTDTSPTLFRPVRGSFIPFSDGARSCLGRRIAMVEMVAAIAV
LFQKYSVELAVDASDEEVQMMVPEQRRHVYAKAQEKAKETVQQAQSVVTL
KLTGGRHVPVRFVRRGKERFMGNEASC*
7873
>CYP534B1 old name = CYP588A1 Magnaporthe
grisea MG06872.4 44% to CYP534A1
AACU01000608 cont2.1276
MSGIRVISAVAVAWALAALFTGFWKLQRNIASAKRTGFNYVICLYAAMPH
LCNADELPASVLTKDWAFKIDHGEIWRKLGDTFMVITPWTLIVYTRCPEA
IQQITSRRDDFPKAVEQYGVLEMLGANIVTTEGAVWKMHRKVTSSLFNEV
SAANAFEETVRQTQSMLRIWRGHSDDDGQDGQVAADGRTISSLAHDTMTL
ALNIIGTIGFGLRFLWPGEKASDNQDPRMNKYTQSEKDSNYLMTFPNATA
GMLENIFAILLVPSILLRHLPFEWARSAHESNVTYVRYMRELVKDKTEDL
HKGVPKTDEHMDIVGALVRAKDDQKKQQDVGKTDIIPPGLQLTDDHIISN
AFIMMLAGHETSANMLHFAMTLLAAHPSSQRAMQADLDRLFPDGDEEATG
WRFENCINDLLTSMPGAVLNETLRFLPPVVVIPKQVSPSRDQVLRVDGDS
VEHVLPAGTIVSVTVVSAARNEKYWPPNEAGESDVHEWIPERWFRASSSS
SPPPVETAQRRTGDSRAADEDVTDDEGDGLETTSAGADKPMFRPVRGLFV
PFSDGARSCLGRRIARVETVTALAVVFRKYSMELAVDEWADDEAVKRMND
KERAELYHKAIARCMETLKTATSTLTLKLPKDQCVPVRVVRRGKESNQGR
IEYISAPPRRVKQSQPPHPKNPGALVMMPLGLKIDVENE*
>CYP534C1 old name = 588B1 Fusarium
graminearum FG09916.1 AACM01000411 FGcontig1.411_scaffold7
MQTVLLLVGSAILYAVYKYVSGLRCNIEAAKKSGLPYIVAPWSPISVPWV
LGYKGLVPIIKLLPKPLWEEWLEVLTPGFSYNTRHDAFARHGDVFIIVSP
NMLYMMTCNAEAIRQITSRREHFPKYVESYEILRVFGNNVLTSEGAIWRN
HRKVTSASFNERNAALVFQEAIHQAQGLVNMWMGPGGEDSGTINTLDEDT
MRLALHIIAYVGFGLKLLWPGESLPAKANLKMAKYGSPEATAGHKMSFVA
TIATALECILLILLVPRWILAMMPFKKTRLAADSHDEFSKYMHELMDEKI
EEARKGEHVDGMDLMGQLVRSSYATGIGEGMQSKKGALSRDEIQGNAFIM
LVAGHETTAGALHFILLELANNPASQRRLQNDIDEIFGGKEPSSWDYDAL
IYPMMASMLGACMNETLRMTPAVVEIPKKVPPKQEQVITIDGNSHLIPGS
TIISLVAVSIHRNPRYWPGRPSHIYAGEDDINDWVPERWYRSYEAAAKPT
ESDIAAPENEDFGGYKGPDTSSQLFRPERGAYIPFSDGPRSCLGRRIAQV
EIIAALAVLFRDYSLELGVDEWANDEEIERMNKEGRRKVYAKAQSASRAK
ILGATSLLTLKMNGDYVPVRMVKRGQERVQ
CGINGDERVAKKCRVARVTR
LPAHDYFSNSKFAARKKSQVVKHADWCKVTVIPPK*
>CYP534C2 Nectria haematococca
e_gw1.6.655.1
Necha1/scaffold_6:586178-588240
71% to 534C1 = 0ld 588B1 F. gram. may be too
long, add one extra phase 1 intron after PRWLL
Note: the region between PERW and heme motifs
is about 40 aa longer than usual
And the C-terminal tail after the heme is about
40 aa longer than usual
MQSVLILVGAALAYAVYTYISSLRQNIAEAKRSGLPYIVA (1)
PCSPIFLPWQLTFKLWTPIIKLFPKPWWERWLE (2)
VLTPGFSYRTRHDGFAKYGDIFMVVSPKLIITMVCNAEAVHQITARREHFPKYIETYEILQQFGDNV
LTTEGAVWRMHRKVTSASFNEKNAALVFKESIHQAKGMVTMWMGSNEDDSGTIHTLDRDTMRLALNIIGY
VGFGFRSLWPGETLPADVNPRLAKYSSLEPSAGHKLSFVSTVAILLEYILMLLLIPRWLL
(1)
RLMPFKKAHLAADAHEDWCKYMQEMMDEKIQEAQRGERVEGMDLMGQLVRSSYGTGETQGKQ
GPEPKKGSLTRDEIQGNAFIMLVAGHETTANAMHFILLELANNPASQRRLQKDIDDILGGRDPSSWEYEG
LVNSMMASMLGACMNETLRMIPAVVEIPKKVTPGQDQVITVDGKRHLLPRGTVVSLVAVSIQRNPRYWPA
RPSKLHPGEGDINDWVPERWYRKSEDPVAKETDTEEPEVEDFGGYGGSDISSQLFRPERGAYIPFSDGPR
SCLGRRIAQVEIIAALAVIFREHSIELAVDEWASDEQVESMDREQRREVYAKAQTTSRNKLLGATSVLTL
KMNDDHVPVRLVRRGQERFTSWI*
>CYP534C3P Fusarium oxysporum
60% to CYP534C1 Fusarium graminearum & = frameshift
FOXG_05507
ILLI*ITILYLIYTFTSNPRQTTVLSKESGVSYTIA
()
VGAGGNDSGTITTLNQNIMRPTPNFIACPGFGLY*IW
PGESLPSKADPRMTKYGSPKPIADHELSVATAIATAPENILMLPPYHAGFSV (1)
SLMPFKRTQIAAKSSE*FGEYMQELMDENIIEARRGERIDGMDLMG*LERSS
YRTDVGPHPQGKELNKGALSQDDIRGNTFIMLAAGQETSAGVLQFILLELANNP
VSQRSL
HGAIDETCGDGDPSLWDYENLINPKMASMLGACINQTLRMTPAVVEIPEAVPLN*GQIVT
IGGKSH &
VPSKTFISSGAVSAHRNPRCWPGRPSLINDGKDDINDWVPERWYRNSQESTARS
TESGCQPRDEEFGSAATSTLLFRLEGDSFIPFSDGPRSCLGRRISQGEIIATLAVLFKDH
SLELAVDDWASDEQ
MDREARREVYAKAQSSSRKKIRGATSVLTLKIRDGHVLVRLVK
>CYP534C3P Fusarium verticillioides
61% to CYP534C3P Fusarium
oxysporum
no gene model
VFTLRVPYREGHEGFTSRRDVFLVESPGILFLVV*NADAIRKIFSRREHIPKCAPKHEKL
RQFSYDVFAAEGEIWRYKEMQYRVLSKIDTALLLRSLIQKAQVLVEM
GTGERDSGTITTLNQNRMRQTTNFIPFPGFGIY*ISPG*SLLSKADPKMTKYRYLRSI
&
IATTIAAASTNILVLP & PEHTGL
TIVLLPFARTQIAGKSSREFG*YMEKLIDERIIEVRQSERTDDM
&
LQFNC*SWQTTQVPQRSLRGAINEICGDGYPSLCDYENLINISMASMSGVCINDTP*MTY
ISAVFEIPVEVSPKQGQTITIDNKSHL
SKTFMPSCRNPRWWPGRLSLINGCKDDINEWVSELRHRKSRESIARSTGS
GRQPRNEEFGSPATSTHLFRPEVDSFI
PFSEGPRSRLGRRISEQGIIATLVVLIKEYFLELATDDWTSDEK
MNREARRK VYAKAQSSSNTK
>CYP534D1 Mgr039 Mycosphaerella graminicola
39% to CYP534C1, 41% to 534A1, 41% to 534C2
MFLNLVLATLGLTVLYIANCYRCF
RINLASAKQSGVPYICLPVYTFDRFWLVTHKLWLPFIGLLPKAWTESWIVYLSPEY
IWTKKYDLYKDLDTDVVILVAPGANTMIVADPEANTQITTRRNDFPKPIWLYTSLDLFGKNVVSTEGANWRHHRKITSPP
FSEKNNVLVWKESLTQAECMMTEWVGTGSDESKSVWSVASETMRLSLHIISRAGFGVRLHWPHENRDDSIPEGHTMTYKG
ALETLLHRILTVILTPRWMLANSPLEIHKLAYRGLTEWGQYMREMYTQKREEVEQGGGDREGMDLMGALVEGAGISSSSK
KSQQLLTDDEILGNAFVFILAGHETAANTLHFSILFLAMKMASQRHLQKDLDDLFGDRPASEWSYDEDLPKLFGNMCGAV
MNEQLRLIPPVTGIPKFVDTKGPQGLRVGDKHVTVPAGCYVTLNTIAVHRNPKYWPHTSEQDLLEFRPERWLLDPSKTAS
SNHADDEGYQVEEGMEFDQTDKRPDTAPTLFRPAKGAYIPFSDGYRSCLGRRFAQVEILAVLAVIFKTWTVELDVSAYMS
DAELKTASEEKKKAAWAKADKKARQLLNDHMGTIITIQIRGDKVPFKFVKRGKENFKW
>CYP534D2 Mycosphaerella fijiensis
67% to CYP534D1 Mycosphaerella
graminicola
e_gw1.8.61.1
MIPYAVLVGCIAVVVTYIANTVRCFQKNLALAKQSGIPYIAIPIYTFNRFWLVTHKLWLPFIRKLPHSWTKDWIDFLVPE
FPWDKKYEGLFKAPGTDIILLVAPGANTLLVADADCTSQITARRNDFPKPTWLYTSVDLFGKNVVSTEGANWRHHRKITS
PPFTEKNNCLVWKESLEQAESMMAGWVGGNKTDSGTIWTVATEAMRLSLHVISRAGFGVKLFWPHEQSVTAIPPGHTMTY
KDALETLLHSLIPLMLLPRWLMKRLPSEGLKRAERSLTEWGQYMREMYEEKRKEVKRGESTEGMDLMGALVKGSGQTEDV
LNSDVEKAQAKQLLTDEEIMGNSFVFILAGHETAANTIHFSTLFLAMHMISQKHLQDDLDRILGDRPVSEWDYDKDMPKL
FGSMCGAVMNEELRLVAPVVGIPKCTAKDKPQGLNLNGRHVVVPPGCYVTLNTAAVHRNPQYWPHTSLEDVSEFRPERWL
LDPSKTNSNTEDDTYDKEEGLDLDGPDQRPDTAASLYRPPKGAYVPFSEGYRSCLGRRFAQVEILAVLAVMFKTWSVELD
VSDYLSDSEFEKASQAEKIAAWEKADARARELLRNGMGTVITIQMRAGKVPFRFVKRGNERFGEILEISGLRRAKGDW*
>CYP535A1 N.
crassa AABX01000066.1 cont3.39 NCU00987.1 (version3)
1314
MGAATLIYEARWLLASVVLAIWAVLKTKQYYRLRHFKGPFGTGWFEIWHG
LAYLSGHPHLKFKEATDKY
(1) 1520
1580
GPIARIGPNELMTTSLELLAHINGARNRYTR
TRWFYIAARFQPNSDNILSELDDNMHTKRRAQMAGG
(0) 1780
1848
YSGKENRELESSVD
IHVAELVQLIRTKYRSTEIKTNPFDLAQKAQYLALDVISHIGFGEPFGML
LSDQDVNGYIKHADQGMNAITYLWGLGLTELVLDTPLMHLLGPSDTAKTG
FGAMTANTRKIISKRLEDDPGMTKGSDMLASWFRHGLDKEQLVTESILQL
LAGAETAATSMRCIMLYLVTNPRVYAKLQAEVDAAVKDGRAPPYPSVVSN
ATQRQLPYLWACCKEGMRMHPPVTNSSQKKVPPEGDAVTVEGKTVYLPGG
TNIGYCVWGLNRDQKIFGGDADCYRPERWLNEEDPKKLAQMNLVHEMLFS
YGKFQCLGKPIALMEIGKAIFG (0) 2855
2934
LMRNFDWSVTNAAEPWKEMNAGALFLTHDFLVEATERSVS* 3056
>CYP535B1 old name = CYP571B1 Magnaporthe
grisea MG04404.4
41% to 527C1 45% to 535A1
AACU01001103 cont2.830
MRCRQPDNVRLIQKVSSDRSATADANLPPQLIKQSLLRMGVFAQLYDQRW
GLALLAVGFYVVSKIHAYTKLRAFKGPVGTGFFNLWNSWALFSQESHLRY
KEACEKYAPGSIVRIGPNDLLTSSPELLMYMSGVRSPYYRSSWFYKSSRP
RPGIDNVFSSSGPEGEATHTRKRQQLAPGYAGKESPLMESSVDQQVTNLV
ALLRERYRSSEARVKPVDMGDKLSFFTLDVISALSLGRAFGDLANDADMH
GYMEATEAAFGYLNALVASPFGMMMQIPLVHRLVGPQETDATGVGKIVCM
ARQNLKERLRHDTKQKSDMVASFVRHGLSFEELVTEGQFQIVAGSDTTAA
ALKGVLLFLLSDRRVYHKLQAEVDAAAQRLALGPEQVIVDGDARALPYLQ
AVVKEGMRCHPPVTLPIPKMVPPAGDTVVVDGREVFLPGGTHVSYAAWAL
HVREDVYGEDAACYRPERWLAEEDPDRLARMQRTHELNFGYGKYQCLGKQ
LALMEVNKVVFQLLRNFDLALTNPIHGWKKVNFLGIFSPGEMLVTVHERV
ADAARKAE*
>CYP535C1 old name = CYP571A1 Magnaporthe
grisea MG08500.4
42% to 535A1 cyan too long AACU01001266
cont2.1600
METLYQGLKSLGVQAIVGIAIASYAVWTIVSYRRLSHIPGPRWTGVSNIP
HSLAFLSGECHKWYHAASNKHGKHFWFLLNPKTSRILTRVGPNSLITSSP
ELWARLNAVRSPYTRTEWFYRGCRLEPGMDNVFTMTNDQEHERRRKQVAS
GYSGKENAKLEADIDANVSALLSLIRSYCTRPGEPSKPMDLAQKIPMFTL
DVISSVGFGTAFGLLAADSDLNGYMASASSGLRINNAIIALGWAVRRFVD
LPIVCKLGPSAKDSYGFGKMIGTVYEAVDRRVRAGDLDKRSDMLASFMRH
GLRGEALRAETLEQVIAGSDTTAAAIRGIMLLLLTSPRVFARLREEVDDA
VRRGGAPQSPEVVAKAQADALPYLQAVIREGMRVKLPVVCFFPRDIPAGG
ETWEVDGEQVFIPGGTDVGYSGNAMHHDKGIYGQDAASFRPERWLDKGAN
LPLMTKTNDLIFGHGKWQCLGKSVAMFELGKVIFELVRNFDWTVENPEKA
WDLHNYNGLMHIENLWVQVQERS*
>CYP535D1 Aspergillus nidulans AN9296.1 40%
to 527C1 N-term does not match
MPLATLREPAIPLLCGLLALYVLRVIMTYAKLMRFRGPAWTGISNWPHSI
AMLRGSCHEFYAQANEKYGTRTWQPCLPILTVLNRARPNRPSRPSSAHHL
VSGGLDARQQQAWLQALRLTPADSVFGAKYSGRENTDLEFSVDKQLQNLL
DLIRAKYVSSCEQAVPMNLAKKVQYFTLDVISSVGLGKAFGMLEADRDVD
QYLQSSDEGLAIGNAALALGFSNINQAPFIGKFFAPSPKDNNGFGRLMTT
CFRFVDERAASATDKRSDMLASFIRHGLSGEELRTEALEQILAGSDTTAG
AIRGTLLHLMTNPRVYVKLQREIDDAVHRGLAPSAGQGLITAAQAKQLPY
LQAVIREALRVWPPVSNIFPRDVPKDGDTVVVNGQSIFLPGGVCIGYSAY
AMHRSEKIYGKDAKAFRPERWLLEPNPTKLALMVRTNDLIFGHGKFQCLG
KPVAQVEIGKMIFELLRNFDLALLNPTHPWDARNNLGLFTISNMWVQVTE
RTAGLL*
>CYP535D2 Nectria haematococca
e_gw1.4.832.1
Necha1/scaffold_4:327672-329378
57% to 535D1 Aspergillus nidulans, 47% to
535C1, 44% to 535A1, 41% to 570C2
This gene model seems correct
MAVVAVLLDNLVPLLLCCLGLFIVRKLVVYNKLKQFGGPRWTGFTDWPHSKAMLQNRCHEWYEEANHKY
(1)
GPIARVAPTVLVTSSPEVWMHVNNKPGYKRSDWYYNACRIEYRKDNVFSQTDNDKHDQRRKQMAPG
(0)
YSGRENLELEKSIDLRVQELIDLIRSKYLSTQDLIVPVDLAQKIQYLTLDAISSISFGKEFGMLRSDSDVDG
YLQSSEEGLAAGNFALALGISWMAHAPVIGAHIAPSPKDDTGFGKMMNACFRCVDERAANPTDKRSDMLA
SFIRHGLSGAELRSEALEQLIAGADTTSTGIRGALLYIITNPRVYSKLQKEVDNAVQSGQVSEGIIPLSE
SKQLPYLQAVIREALRMWPPAVNIFSRDTPPGGDTVTVNGESIFLPGGVSIGYSGHGIHHSKEVYGEDAK
VFRPERWLNADPEKLAAMVRTSELVFGHGKFQCLGKPVAQLELGKTIFE
(0)
LMRHFDLALVNPTKPWDARNSLGLFTISDMWVQAMDRTNESKA*
>CYP535D3P Fusarium oxysporum
seq. runs off the end of the contig
75% to CYP535D2
FOXG_17443
MGLFASVSEHRELLVCALLGLFVIKKLVVYSKLRQFGGPRWTGFSDWPHSWAMLQDRCHELYEQANLKH
(1)
GPIARVAPNILITSSPELWIHVNNKPGYKRSDWYYNACRIEYRRDNVFSQTDNQKHEQRRKQMAPG
(0)
YSGRENPHLENSVDERVQEFLDLI &
RNKYLSSDTQAIPMDVAQKVQYLTLDIISGIGFGKPFGMVQKDSDVDEYLKSSEE
>CYP535E1 Aspergillus oryzae
GenEMBL
BAE61757.1
46% to
535D1, 49% to 535C1 Mg, 47% to 535A1
52% to
535D2, 44% to 535B1 Mg
revised
3/18/2009
MGLVELVLETRWLIVGSLFILYFLKKFQAYYRLRKFKGPLSCGFSHFLHTKAVLSLRCERWYKEMTDQYG
SIVRIGPNALITSSPELWAHINAVRSPYKRSDWYYHAARFKPGEDHVFSETNNERHDRRRKQMLMGYSGK
ENLSLESDIDLRVLDFLDLIRNRYLSTEDCLKPMDLAKKVQYLTLDVISTVGLGNSFGMLKADKDVNDYI
KSGEEGLWVSNFLMGTGLHWIMQIEWVGRLLGPSTDDLKGFGKMMATTGQMVAKRLQSPTNARSDMLASF
IRHGLIGNELWMEAFEQVLAGSDTTASGIRGILLCLLSNPRVYKKLQAEIDGAVQDGRAPSTGIISDAQL
RRLEYLQAVIREGLRIFVPVVNIFARDVPPEGDEVIVDGESVQIPGGTWIGYSALGMHLNKATYGEDAEV
FRPERWLIDDKDHLANMTRVNDLIFGYGRWKCLGQTVALIEIGKTIFE
ALRNFDWALANPEQPWRRKNVNGLFAVSDMWVTVTAREQLGSCL*
>CYP535E1 Aspergillus flavus
99% to CYP535E1 Aspergillus oryzae
AFL2G_09395
MGLVELVLETRWLVVGSLFILYFLKKFQAYYRLRKFKGPLSCGFSHFLHTKAVLSLRCERWYKEMTDQYGSIVRIGPNAL
ITSSPELWAHINAVRSPYKRSDWYYHAARFKPGEDHVFSETNNERHDRRRKQMLMGYSGKENLSLESDIDLRVLDFLDLI
RNRYLSTEDCLKPMDLAKKVQYLTLDVISTVGLGNSFGMLKADKDVNDYIKSGEEGLWVSNFLMGTGLHWIMQIEWVGRL
LGPSTDDLKGFGKMMATTGQMVAKRLQSPTNARSDMLASFIRHGLIGNELWMEAFEQVLAGSDTTASGIRGILLCLLSNP
RVYKKLQAEIDGAVQDGRAPSTGIISDAQLRRLEYLQAVIREGLRIFVPVVNIFARDVPPEGDEVIVDGESVQIPGGTWI
GYSALGMHLNKATYGEDAEVFRPERWLNDDKDHLANMTRVNDLIFGYGRWKCLGQTVALIEIGKTIFE
ALRNFDWALANPEQPWRRKNVNGLFAVSDMWVTVTAREQLGSCL*
>CYP536A1 N.
crassa AABX01000239.1 cont3.377 NCU06526.1 (version3)
11364
MGVVLKVKDGKVSPTRVLVGATATVLASYWLYILLFAIVIRAASKRYASP
LRKYPGPFLASCSRLWKVLSTASGRTHLDHIELHRKYGPVVRIAPNEVSV
ASPEAARTLLSAGKRFFKTPFYSVFPPAENPDIFTEIREDAHAQKKRVAN
VPYSMAAMQQLSPFIDDTIELLVRKIDEHIAQHKGVFDLGDYLHYFAFDV
LGEVAFSRSFGFLAQGRDVDNAIKTIDKSQTYNGIVGQVPELDHLLRRNP
LWRSIPWLSTKNALITRMALEEMGRRQPFNKDTAVLQTGDTRQDLMASLI
LGHLKSPEKFGVGDVFAVAHGAI (2) 10399
10314
FAGSDSTASTMQSFFYHVLSSPSTYQS
ILYEIQSAVATGVIPATGNLTWNEAQTLPYLQACLKEAMRLRPA
VGLNITRFVPPEGAELDGHFFPGGTSIAVNGWVLHRDKLTFGND
ADEWRPERWLENEEEARRMERYMFQ (0) 9895
9825
FGGGSHLCIGRNLALLEINKVVPRLLRDYRFELAHPGRELKATA
SFFVVQSGLEVFVRRA* 9643
>CYP536A2 Magnaporthe grisea MG05235.4 70% to CYP536A1 AACU01000803 cont2.971
MDVNVETSAKAPLVSGLAGFILDNWAIIISAALVIRALYRRYVSPLRKYP
GPFLASISRLWKVISTASSQTQFDHIRLHEKYGPVVRIAPDEVSLASPEA
ARLLLSAGKRFTKTDFYSVFPPPENPDIFTEVREDVHARIKKVANVPYSM
AAMQQLSPFIDDSIEALAHKLDGIADEPTDDRDGPRVDLGLWLHWFAFDV
LGEVAFSRSFGFIAEGKDVDGAIETIDRSQRYNGIVGQVPFVDHLLRRNP
LWKFVPSFNTANALITKIAMSELARRKPFDKESEGKWRGGDGRQDLLASL
IKGHLKDPERFSEGDVFAVAHGAIFAGSDSTASTMQSFFWHCFSDPRVHE
TLLNEINSAVAGGHIPSSGNISWSDAQTLSYFQACLKEAMRMRPAVGLNI
TRYVPPEGAELGGHFFRGGTRVAVNGWVLHRDKDVFGDDAKDFRPERWLE
DAENAKRMDRYMFQFGGGAHVCIGRNLALLEMNKVMPRLLRDYNLHLVNP
GKPLKATSSFFVVQSGLDVYISRKKK*
>CYP536A3 Nectria haematococca
fgenesh1_pg.scaffold_32000050
Necha1/scaffold_32:150926-152616
52% to 536A2 Magnporthe grisea
Do not remove first small intron
MALLGNIPVTLSVVSTARTFATQHLFACLIAFILIRCLYKRYFLPLRHFPGPPLASVSRLWR
(1)
VWSVWTGKNEEHYISAHRKY (1)
GPVVRTAPNELSFSSATTALDIFKTGKGLDKTDFYGVFPPLYERDIFTEARESVHRVKKRYASPGFSL
QAMQQSTPRIEEAERLLLCKLDEYAHGNKTCDLGDWLHFFAFDVLGEAAFSTRFGFLEAGFDVGGAMESI
NRSNRYSGIVGQIPGLDPFLRRNPLRGYISYFASKMPLITRIALDQLESRVKPGNQKFAKFTDLLNSTMQ
AQKQNPEALSHGDVFGIAHGAIFAGSDSTASTMQSFMWHVLSQPRVHNALAKEIMSASLSEMVQYDESQK
LHYFQACLKEAMRVSPAVGLNISRRVPPTGAEIGGLKLSGGTEVAVNGWVVHRDKQVFGQDADNFRPERW
LEADKDTLR (0)
FGGGSHVCLGRHLALLEMSKVLPELFRRYHLQLVNPDQPLQRSSTFFVVQSGLHVHLKLREMP*
>CYP536A4 Mycosphaerella fijiensis
58% to CYP536A2 Magnaporthe grisea
estExt_Genewise1Plus.C_11313
MLKTYWLLLIPTILLVRFLYYRYASSLRHYPGPILASGSRAWKAVWSVWSGHTEIDHIKVHEKYGPVVRIAPNELSFASP
LVAKEVLSAGKGFHKTDFYGVFPPPENPDIFTETREAVHAAKKRYAANPYSMATMHTMAHYIEDTERLFAKKLDAMCASK
DQYCNFGNWLHYFAFDVLGEIAFSRKFGFLESGYDLEKAIKTIDDMQWYDGIIGQIPEWDFAFRRNPLWKLIPSLNTANF
LITRMALQEMDQRKKLGSKELGRKDLLSQLFAAHEKAPDVFKEGDVFAVAHGAIFAGSDSTASTMQSFTHCVLRDPRIYA
KLQKELDEATASGRLSEMPQWNEAQALPYFQACLNEAMRLRPAVGLDITRLIPAEGAEIDGHKLPGGTRVALNAWVLHRD
EDIFGIDSKSFRPERWLDGDAKMMQRYMFQFGGGAHLCIGKNLALLEMNKTLPLLFRDYDFQLLRPQEELKYHSTFFVVH
EGLEVRISKRTTRP*
>CYP537A1 N.
crassa AABX01000723.1 AABX01000717.1 revised
57% to CYP537A4
521086
MTLLLLLPIIIFLLHNLIYKPLTSPLSSLPGPLYTKFTSLVLK
YHELRANRTRWIHALHVRYGPVVRIAPNEVSFASREGVKEIYC
SGGSGFDKSGWYDLFKIYGRR (2) 521406
521667
TMFTFLKKDD (0) 521696
521762
HAKRKRILADRYANSNVMRQAPLSGIIERADR
VVKRCAESLDGSLDLY (0)
AVHSYAYDCSIRTTCFHPYGTDXLRN
QQDEEIMREITFDDSLQ
(1)
97
NRQLSYYSPTLHKAISKILYICGIK
PRETPLADKFILDTAAKTDAAPFTLLDRLH (1)
NSKIAQ
IDQLDIAAELLDHMVAGIDTTGDALCFLMWELSQPRSRQIQTKL
REELLSHPSSDINFDKLPYLDAVVMEGLRCFPAIPMSLPRIVPR
GGKTIDGYFLPEGTTASCQAYSMHRIDMEAWGPDPDAFRPERWF
EEKGDAARKKLFFAFANGARGCIGKH (2) 801
907 LALAEMKILLREVYSKFTTVPDKTMTEE
DMEMEDQLISTRPAGLKCLLKFEPIGGQ* 1077
>CYP537A2 Fusarium graminearum FG05426.1
AACM01000224 FGcontig1.224_scaffold3
MFILSP
SLISGAAALFLVAYIITRLSSATAKIPGPFVSNFTSLVLKWQELNANRTV
YIHELHKRYGPVVRVAPNEVSFTSIAAVKEIYGSGGSGYDKTEFYNLFQV
YGKRTMFSTLVKGDHAKRRRMIGDRYANSNVMKAAPLAGIKERSSKFLQH
CVESPERTADVF (0)
ALHAYACDCVTHQLFHPYGSNCLQDKQ
DEEMMHQVAADDSLQNRLVQYYSPVLHNLGSKVLASFA
KPRSIPLADNFVIENAQQNGAASFTVLNRLKEKDSVLDTMDMAAECLDHM
AAGIDTTGDVLCFLMWELSQPRSIKYQRLLREEFLRKTDMPFDELPMLDA
VLNEGLRCFPAIPMSLPRYVPQGGRVIDGFTLAEKTVVSCQAMSVHRIND
DVFPEPDKFHPERWLAAEGDADRRRHQWAFSSGGRGCVGKHLAMVEMKTL
LRDVYSRYETEPDESMKSESMVMDDQLISSRPLGKRCLLKFVPVKD*
>CYP537A3 Magnaporthe grisea AACU02000684.1
revised 2X
AACU01001722 58% TO 537A1
MLLFSPSITAIILGVCAAAYLIRCLRSPLRKVPGPWYSLFTGAGLKYNEL
QGQRTRYIHKLHLKYGPTVRLSPSEASFTGPDAVREIYGSGGSGYEKTEF
YDLFTVYGRRTMFSTLDRESHARRKRVLADRYANTNVMKQPALSGIAERA
RRFAELCQGSVGGSLDIY (0)
TTLHSYAFDCVTHHLFHPLCTNSLQDKQDGDIMREVTFDDSLK
(1)
NRLVKYYSPSLYHIVEPLLSFITQPRATPLADKFVLD
TSAQTHASPFTLLDRLHQRKNGGDLEQIDIAAECLDHMVAGIDTTGDALC
FLMYQLSLPSSATFQRKLQAELAANPDHDETPFDKLPYLDAIVQEGLRCF
PAIPMSLPRYVPSGGRHVDGYFMPEGTIVSCQAYSVNRINGDIFPHPETF
NPDRWLEVEGDATRRRCMFAFSHGGRGCVGKHLALAEMKLLLRDTYSRYS
TIPDSKMTDDAMAMSDQIISSRPAGQKCLMRFIPLVDNAT*
>CYP537A4 Nectria haematococca
e_gw1.9.142.1
Necha1/scaffold_9:176128-177897
79% to AACM01000224 Gibberella zeae, 79% to
537A2
gap in seq after TADVF, add cyan seq no good
boundary at intron 3, GA not AG
57% to e_gw1.10.477.1
MLLLSPDFIAGAAALLLVIHVVVRLTSAMAKVPGPVVSNFTSLVLKWNELGANRTMYLHDLHKKYGPVVR
VAPNEVSFTSAAALKEIYGSGGSGYDKTEFYDLFQVYGKR (2)
TMFSTLNKGD (0)
HAKRRRMIGDRYANSNVMKTAPLAGIQVRSKKFIERCVSSPDGTADVF
(0)
(?) xxxIALHAYACDCVTHQLFHPYGSNCLQNQDDEEMMHQVAADDSLK (1)
NRLVQHYSPTLHRVVSNVLASFAKPRSIPLADNFVIENAKEDGAADF
TVLNRLKEKNSVLDTIDMAAE
CLDHMAAGIDTTGDVLCFLMWELSQPRSIKYQRLLREEFRNKPDAPFDE
LTLLDAVLNEGLRCFPAIPMSLPRYVPQGGRVIDGFSLPEKTVVSCQSFSVHRINDDVFPDPDKFYPERW
LETDGDADRRRLQWAFSSGGRGCIGKH (2)
LAMAEMKTLLRDVYSQYETEPDESMSTESMAMDDQLISSRPLGKRCLLKFVPVTEEEKNQ*
>CYP537A5 Nectria haematococca
e_gw1.10.477.1
Necha1/scaffold_10:12960-14643
MFLLSIPALSIAIAVCALFYVWKCVSSPLWAAPGPFLSRFTPFMLRWNEFNANRTLYIHSLHLKYGPIVR
IAPNEMSFSSYEAVKEIYGSKGSGYDKSTFYDLFTVFGRR (2)
TLFSTLDKTA (0)
HAKRKRLLADRYANSNVLKPASLNGIENRAREFARQCGDSTGSSVDVY
(0)
IKLHAFACDGVTHHLFQPYGTDCLGNPGDREMMDQVNADDSLR (1)
SRLFMLYTPTLYKYSS
KILDCFFEPRATPLADNFVTKRSKLDDPEEFTLLSRLRSKLGDELAEGDIASECLDHMVAGIDTTGDVLC
FLIWELSQPRSAQFQDELRRELKGNPDMAFDKLPVLDSIVQEGLRCFPAIPMSLPRVVPKDGRVIDDIFV
PEDTIVSSQAYSVQRHHAHVFPEPDRFNPHRWMSNENDAEMRRHIFAFSYGGRGCIGKH
(2)
LAYAEMKLLLREVYSQYQTVPDPSMTEESMRAHDQIISARPFGQKCLLRFVPTAA*
>CYP537A6 Fusarium oxysporum
87% to CYP537A4
FOXG_09472
MLILSPSFMLGAAALLVITHIIIRLTSATAKVPGPFVSNFTSLVLKWHELNANRTMYIHELHKRYGPVVRVAPNEVSFTS
IDALKEIYGSGGSGYDKTEFYDLFQVYGKRTMFSTLVKGDHAKRRRMIGDRYANSNVMKQAPLAGIQERSKRFVERCVDS
PDKTADVF (0)
LTKTALHAYACDCVTHQLFHPYGSNCLQNKDDEEMMHQVAADDSLQ
(1)
NRLVQYYSPILHRLGSSILTSFAKPRLIPLADNFVIENAK
ENGAADFTVLNRLKEKDSVLDTIDMAAECLDHMAAGIDTTGDVLCFLM
WELSQPRSTKYQRLLREEFRSKPDAHFDELPMLDAVLNEGLRCFPAIPMSLPRYVPHGGRVIDGFSLPEKSVVSCQALSV
HRINDHVFPEPDKFYPERWLEAEGDADRRRHQWAFSSGGRGCIGKHLAMAEMKTLLRDVYSRYETEPDESMKSESMAMDD
QLISSRPLGKRCLLKFVPVKG*
>CYP537A6 Fusarium verticillioides
96% to CYP537A6 Fusarium oxysporum ortholog
FVEG_07101
MLGAAALLVVTHLIIRLTSATAKVPGPLISNFTSLVLKWHELNANRTVYIHELHKKYGTVVRIAPNEVSFTSIDALKEIY
GSGGSGYDKTEFYDLFQVYGKR (2)
TMFSTLVKGD (0)
HAKRRRMIGDRYANSNVMKQAPLAGIQERSKRFVERCVDSPDKTADVF
(0)
LTKPALHAYACDCVTHQLFHPYGSNCLQNKDDEEMMHQVAADDSLQ
(1)
NRLVQYYSPILHRLGSSILTSFAKPRLIPLADNFVIENAKEDGAADFTVLNRL
KEKDSVLDTIDMAAECLDHMAAGIDTTGDVLCFLMWELSLPRSIKYQRLLRQEFRSKPDA
NFDELPMLDAVLNEGLRCFPAIPMSLPRYVPHGGRVIDGFSLPQKTVVSCQALSVHRIND
HVFPEPDRFYPERWLEADGDADRRRHQWAFSSGGRGCIGKH (2)
LAMAEMKTLLRDVYSRYETEPDESMKCESMAMDDQLISSRPLGKRCLLK
FVPVKG*
>CYP537B1 Aspergillus nidulans AN8905.1 45%
to 537A2 53 clan
revised 7/19/07
MLTFYLAASIIVTVLFMRRLCSPIAKLPGPWYATFTSWVLKYHEFTSNRR
LFIHDLHKKYGSTVRIAPNEISFASLEAIKEIYGSGGSGYDKTELYDLFRQFGIK
TMFSTLDKHS (0)
HSQRKRELADRYAMSNILREEHVSAIVDRARAVVSRCAASAESVD
VYVWLHCYALDGVTNFMFSPGGLHSLDSEHDFKIMEELTYHQSLQKNLLH
YYLPTVAAYFPPCLTPRRSPKTNEYVLKMCAQQLPSQHSLVAKLARKDSP
LNHTQVAAECKDHMAAGIDTTGDGLCFLMWKLSQPHNIRFQERLWEELRT
ARPDIPLDKLPYLDAVVKEGLRCAPPIPMSFPRYVPTGGRSIDGHFVPEK
TIVSCQPYTVHRLDENVFPEPDSFNPDRWMVEKGAVERNRLFFAFSTGGR
GCTGRNLALVEMKILLREVYSRFRTTVAKDMHGCMDIDDQIISSRPLGQT
CKLRFSET*
>CYP537B2 Aspergillus oryzae
GenEMBL
BAE66494.1
67% to 537B1
note:
retains small intron due to lost phase 0 boundary
MWSLWLSSILLVGLYLFKRLSSPLAKVPGPWYTNLTSFCLKYHEFTATRRLFVHRLHKKYGPVVRLAPNE
VSFASLDAIREIYASGGSGYDKTEYYDLFRQYGIN (2)
TMFSTLEKQE
ISAYITIEAIATNDVQ
HSHRKRELADRYAMSNIVRDKHVSAIKERAQAFVSRCAAIEGSVNVY
SLLHCYALDGVTNFMFSPGGLKSLDNTKDYEMMEELTYHQSLQKNLLYYYLPRLAPYFPSCLHPRPAPR
ANAYVLQMAGQQHPEAHSLVARLTRKGSPLSHMQVAAECKDHMAAGIDTTGDALCFLMWELSQPQNLQFQ
DRLHKELLSTSDDTPLDKMSYLDAVIKEALRCAPPIPMSIPRYVPSGGRTIDGYFIPENTIVSCQPYTVH
RFNEEVFPEPDRFNPERWLEEKGFNDRNRLFFAFGTGGRGCTGKNLAMVEMKILLRELYSRFRSSVAPDM
TASMDLDDQIISARPKDQICKLNFAVRGDDVDTA
>CYP537B2 Aspergillus flavus
98% to CYP537B2 Aspergillus oryzae
AFL2G_11813
MWSLWLSSILLVGLYLFKRLSSPLAKVPGPWYTNLTSFCLKYHEFTATRRLFVHRLHKKYGPVARLAPNEVSFASLDAIR
EIYASGGSGYDKTEYYDLFRQYGIK (2)
TMFSTLEKQE (0)
HSHRKRELADRYAMSNIVRDKHVSAIKERAQAFVSRCAAIEGSVNVY
(0)
SLLHCYALDGVTNFMFSPGGLKSLDNTKDYQMMEELTYHQSL
QKNLLYYYLPRLAPYFPSCLHPRPAPRANAYVLQMAGQQHPEEHSLVARLTRKGSPLSHMQVAAECKDHMAAGIDTTGDA
LCFLMWELSQPQNLQFQDRLHKELLSTSDDTPLDKMPYLDAVIKEALRCAPPIPMSFPRYVPSGGRTIDGYFIPENTIVS
CQPYTVHRFNEEVFPEPDRFNPERWLEEKGFNDRNRLFFAFGTGGRGCTGKNLAMVEMKILLRELYSRFRSSVAPDMTAS
MDLDDQIISARPKDQICKLNFAVRGEDVDTA
>CYP537B2 Neosartorya fischeri
100% to CYP537B2
Aspergillus flavus
seq runs off the contig end
LADRYAMSNIVRDKHVSAIKERAQAFVSRCAAIEGSVNVY (0)
SLLHCYALDGVTNFMFSPGGLKSLDNTKDYQMMEELTYHQSLQ
(1)
KNLLYYYLPRLAPYFPSCLHPRPAPRANAYVLQMAGQQHPEEHSLVARLTRKGSPLSHMQVAAECKDHMAAGIDTTGDA
LCFLMWELSQPQNLQFQDRLHKELLSTSDDTPLDKMPYLDAVIKEALRCAPPIPMSFPRYVPSGGRTIDGYFIPENTIVS
CQPYTVHRFNEEVFPEPDRFNPERWLEEKGFNDRNRLFFAFGTGGRGCTGK
(2)
NLAMVEMKILLRELYSRFRSSVAPDMTASMDLDDQIISARPKDQICKLNFAVRGEDVDTA
>CYP537B3 Aspergillus niger
e_gw1.14.367.1|Aspni1
71% to CYP537B1
MLGLWCAAILILVFLYQRLSSPISKLPGPWYTKLTSLVIKYHEFSASRRVFIHQLHKRYGTIVRIAPNEVSFASLDAIRE
IYASGGSGYDKTEFYDLFRQ
TMFSTLDKQT (0)
HSERKRQLADRYAMSNILREHHISAIRHSAKAFVSKCAAVAKSVDVYVYL
HCYALDCVTHFMFSPSGLNSLTDDNDFELMEELTYHNSLQKNLLPYYLPRLAPYFPSWLLPRRAPKANMYVHRVTAETNP
DEHSLLARLLRKDASLSKSEAAAECKDHMAAGIDTTGDGLCFLMWELSQPHNFPFQDRLYEELRSAPEDTPIDRLPYLDS
VIKEALRCAPPIPMSFPRYVPRGGRTIDGVFIPEGNIVSCQPYTVHRLDTKVFPEPDMFNPDRWTKDEGFNERNRLFFAF
STGGRGCTGRNLATVEMKILLQEVYSRFRTTVAPDMTSSMEIDDQIIASRPKGQKCRLIFTPREI*
>CYP537B4 Aspergillus terreus
73% to CYP537B2 Aspergillus flavus
ATEG_07898.1
MLSLWCLGIVGLGVFLFRSLSSPVAKVPGPWYTLFTGLVIKYYEFTATRRVFIHDLHKRYGPVVRIAPNEVSFASLEAIR
EIYASGGSGYDKTEYYDLFRQFNIK (2)
TMFSTLDKHT (0)
HSRRKRELADRYAMTNILREIHVSAIRERAEAFVAKCAAIAKSIDVYVYLHCYALDG
VTNFMFSPGGLRSLDRAEDFAIMEELTYHQSLQKNLVHYYLPSIVPYLPSFLIPRRSPLTNDYVMTMTNQAQPEPHSLIS
RLARPDSPLSSLEAAAECKDHMAAGIDTTGDGLCFLIWELSQPQNMRIQDRLYEELQSVPSDTPLDKLPYLDAVIKEGLR
CFPPIPMSFPRYVPAGGRTIDGYFLPQDTIVSCQPYTVHRLHEDIFPDPDRFYPERWLEEKGAAERNRLFFAFGTGGRGC
TGRNLAMVEMRVLLQAVYSRFRTTVASDMTGCMDIDDQIISSRPKDQTCRLDFARRE
>CYP537C1 Nectria haematococca
e_gw1.38.28.1
Necha1/scaffold_38:43917-45683
43% to 537A3 Magnaporthe g. 42% to 537B1
add cyan exon
MIAELALQSKTLGLLLVAFGSVLVIAIVFYHVAFSPMRAIPGPWYLRLTSLFVKYHEFHGTRRLWIHDLH
LKYGPTVLLAPNEVSFASASALKQIYSSGGTGLPKDHMYSLFKAQGHT (2)
NLFTALDNKE (0)
HREKRKQLSERYSNTSILKSPILDVIKERAEAFATECRKTASADVY(0)
FLLHGYALDCVSAMLFHPHGTKSIEPGDQREMVHLLSYHDSRK (1)
TLVLERYWPLLQRIYKFLSHKPTKGGKPIDDYVWS
SMSKTDYSEFSLMARLLHDKKMPVDAIASECYDHITAGIDTTGDTLCFLLWELSRPSQQERVKRLREELV
VGKSSGQPLDTLPYLNAMLQEALRLWAPGMQSLPRNVPAGGREIDGHFVPAGTVVSCQSYTTHRYDDDVF
QDADAFVPERWLNPDGDSERGRLFFAFGSGARTCIGRH (2)
LAMAEMRALVHAIYSKMRTVPAQDMVASMEFNDQIMTTRPEGLCCKITFEPLTD*
>CYP537D1 Nectria haematococca
e_gw1.23.292.1
Necha1/scaffold_23:445038-446732
51% to e_gw1.9.142.1, 48% to 537A2 47% to e_gw1.10.477.1
43% to CYP537B1 AN8905.1 in CYP53 clan
add cyan region
MALLSLPLLAGATLLLFVIALVRRLFSPLSRFPGPKLGLLTPWQLRYHELQGKRTQYIHQMHQQYGNVVR
VAPNEVVFSSLEAMKEIYLSKGSGYDKPSFYDLFSQFGLR (2)
TMFSTREKGP (0)
HSKRRRIIADRYANSNVIRDSALHGIQERSQNFIKRCSEAPRQELDVY (0)
LFLHCYAFDCVTHHLFHPHGSDSILKQSD EETLVEAVFDNSLA (1)
RRLFIHYNPTIGSLMGKLGVFGKS
RDIPRTRQLILDGATGGPVADFTLVSRMREDKFGMGPMVIASECMDHTLAGIETTGDALCFLMWQISQPG
YEIIQERLRDEFLANEGVSFEQLPYLEAVVKEGLRVFPSIPMSLPRCVPPEGASVDGHWLPGGTLVSCQP
YSMHRMDEVAFPEPDSFKPERWLEEKGLAERNRLFFTFSNGGRACIGRH
(2)
LAVAEMKTLMRDIYSTFKTTPAEGMAADMSMDDQIFTSRPKDQKCILKFTRWEEELV*
>CYP537D2 Fusarium oxysporum
78% to CYP537D1 Nectria haematococca
FOXG_09731
MATLSLAHLAGAAVLIFIGVLIVRLRSPLASLPGPRLGLLTPWQLRYHELRGKRTQYVHRMHQKYGNAVRVAPNEVVFSS
LDAMKEIYLSKGSGFDKTSFYNLFSQFGLR (2)
TMFSTLQKGP (0)
HSQRRRVIADRYANTNVNREASLHGIQERSQNFIARCKDAPKQELDVY
(0)
MFLHCYAFDCVTHHLFHPHGSDSILQASDEETLHEAVFDNSLVSK
(2)
LLNYYHPTLGSVAGKLGLFGKSRGIPRATELVLNGVKKGGVADFTLVSRMQEEKFGMGTFDIASECMDHMLAGIE
TTGDALCFLMWQISQPGYTFIQERLRDEFRANPDVPSDQLEYLEAVVKEGLRVFPSIPMSLPRCVPEGGATVDGHWLPGG
TIVSCQPYSMHRMDEGVFPRPDSFEPQRWLEEKGSAERNRLFFVFSNGGRACIGRH
(2)
LAIVEMKTLLRDIYSRYRTAPADGMSFDMSMDDQIFTSRPRDQKCNLKFVEWVEVAGC*
>CYP537D2 Fusarium verticillioides
94% to CYP537D2 Fusarium oxysporum = ortholog
FVEG_08745
MAVLSISLFAGAAALIFIGVLIVRLRSPLASLPGPRLGLLTPWQLRYHELRGKRTQYVHQ
MHQKYGNAVRVAPNEVVFSSLDAMKEIYLSKGSGFDKTSFYNLFSQFGLRTMFSMLLKGP
(0)
HSQRRRVIADRYANTNVNREDSLHGIQERSRNFITRCRDAPKQELDVY
(0)
MFLHCYAFDCVTHHLFHPHGSDSILQASDEETLHEAVFDNSLVRK
(2)
LLNYYHPTLGSVTGKLGLFGKSRGIPRATELVLNGVKKGGVA
DFTLVSRMQEEKFGMGIFDIASECMDHMLAGIETTGDALCFLMWQ
ISQPGYTFIQERLRDEFRANPDVPFDQLEYLEAVVKEGLRVFPSIPMSLPRCVPEGGATVDGHWIP
GGTIVSCQPYSMHRMDEEVFPRPDSFEPQRW
LEEKGSAERNRLFFAFSNGGRACIGRH (2)
LAIVEMKTLLRDIYSRYRTAPADGMTCDMSMDDQIFTSRPKDQKCIMKFIEWD*
>CYP538A1 N.
crassa AABX01000024.1 cont3.89 NCU02031.1 (version3)
27319
MLTPTTLLLLSPLLYLLTLLFRTALYRLRARSLGCSPVAVYPHK
DPILGLDLFRESLRAMNTHALLPLWDARFKRYGNTHYTLTLGKW
VLMTNEPENVKVILGTKMAEWPIDGPRLHASVAVLGKKSIFTTN
GAQW (2) 26912
26807
REARGMIRPSFVRDQVADLHCFAKHVGNFLNAIPKDGSTFDMQE
LLLSMTMDSSTDFLLGCSTNSLLQPSPEAKQFLEDFEYTSREAA
KKSRLGTLLNWLPNGEFQATVTRVREYVRAYIRKSQAEKTDKKE
RDYVFLHEILKSGADEEHAIDQVLSVIIAGRDTTAAAMTACFYY
LARNPEAVKKLRKEIFDMEDEMPTWEQLKNMKYLNMIIKEG (1) 26156
26088
LRLFPPASTNSRAPIKDTVLPRGGGPDGKQPILVPKGQVVRWSL
YSLHRRKDIWGEDAHEFRPERWDENLRVG (2) 25870
25787
WEYIPFSGGPRICLGQQFALTQIEYALFKFFRAFKSIEPRDDNG
PLLLRTNLTVTFAKGCLVSATPDSN* 25578
>CYP538A2 Magnaporthe grisea MG02792.4 54% to CYP538A1 AACU01001559 cont2.569
MNRIALWTVASFLLVPFTAHACLQTWHILAGTSSPTGKWRSRATYILSGL
LLKVQYDLFVKLTLELRARRLGCLPAKLYPHKDPVLGLDYFFKALRAAGA
GQFFPFARENLKTIGHTHYAMALGTWVLHTDEPENIKSILATDFDSWEIA
GPRLLPVLDVLGPKSIFTSNGEGWHQARSMLRPSFVRDQVADLACFDRHI
SHLLKKIRSSCQEGMVAFDLQKLFFLMTMDSSTDFLLGRSTDLLVKASPE
AEDFLRAFDYVLFQGAKMARLGPIMMKLPHRKFDAEVQTVRSFVRKYVSK
AMAEKGYQKERSYLFLHELVASGASVEYITDQVLSIILAGRDTTAAALAA
AFYFLSKSPDIVDKLRQEMLEMGEENPDWETLRGMKYLQNVIKEG
LRLAPPVATNSRTSCKETTLPRGGGPDGKSP
VLIPKGTSCRWSNYSAYRRADIYGPDADEFRPERWEDLRVAWEYTPFSGG
PRICIGQQFALTQMSLAIFRILQNFDKIKSKNEGPMGMRAGVTVSLADPG
CLVSMTPIA*
>CYP538A3 Nectria haematococca
fgenesh1_pg.scaffold_1000354
Necha1/scaffold_1:1132876-1134514
49% to N. crassa 538A1
MPHPLWVVTLLTPAILYLRSKYYWLHWMRVHDTQPAPVYPHRDRLLGIDWMLEMSKAIRSHSILQLWDGL
FSSLGNTFWTKNVGAWIIMTNEPENVKALLSGQFETWQIAGVRQAAMVLALGPNAIFSVNGHAWHDARTM
MRPSFVRNQIADLECTDRHVEAFLDRIPRDGQAVDLQELLYMFTMDISTDFM
(2)
FGYSTNILSDPSSEALDF
TRSFDYALLSAAQRARLGWIVLLMPDRKLNEAAATCRRFIDRYVKEALASSREKERPYVFMNEMFASGAS
QEYVRDQLLAMILGGRDTSASTMSSLFWILARRPDVVEKLRAEIAGLDGRKPTWEELKELKYLNMVLKE
(1)
ALRLWAPVSTNSREAVKDTVLPKGGGPDGQSPLFVPKGTACRWSSYSLHRRKDIYGDDAEEFKPERWESLRAK
(2)
WEYIPFSGGPRICIGQQFALTQMSYLITRLFQTFESMEAADDKPMLQSVSTTIALVNGCWVRLTPVGAS*
>CYP539A1 N.
crassa AABX01000502.1 cont3.571 NCU09115.1 (version3)
3508
MGLVEDVAGNLSLKNTPIIFGGVLLGLIVFRYLQVVWQNLRIARM
GLRPPKIRDSGLF (1) 3681
3740
GIKFIKTNVKMAAEHKNLQFWQQMFRSIGGYTGEVRLVGHRIIFT
SEPENMKAILATQFEDYGKGEGFHQEWKDFLGDSIFTTDGDLWHA
SRQLIRPQFIKNRVSDLQCFENHMQMLFRTIANGGALNGEDQMVD
MEAGNGKPVDISDLFFRYTLDAATDFLLGKDIKSLS (2) 4252
4308
TPVQPFADAFQEVQRVQIVIARAGPLNRFVPKKTFWEGLKVIDET
INFYIDRALRLDEEELASKSKGDEGYTFLHALAGFTKNRQVLHDQ
LMAVLLAGRDTTACTLS WAIYELARHPEAVAKLRAEILSVVGPDR
APTYDDLKSMKYLQNVMNETLRLYPVVPFN (2) 4782
4867
VRMALKDTTLPRGGGPDGSQPIVILKDTPVGYSPLAMQRRPDLYP
PVSEKFPDVEMFSPDRWFHWQPKPWQYIPFNGGPRICIGQQFALT
EMGYVLTRLFQRYD RVVSYMDEIDGGKPRMKTDIVLMPGDGVKVA
FFEAKRE* 5295
>CYP539A2 Magnaporthe grisea MG09920.4 64% to CYP539A1 AACU01001746 cont2.1896
MGLVEVVLEHVSVKAAVLWIVGSWVLYLVVKNVLEERKINKLGARAARMP
SRLPLSLDNIIRAVRANIQNRNLQMWRSHMSHSITYTVEGRLLFQRIILT
ADPENIKAILATQFTDYGKGEPFHQEWKPFLGDSIFATDGEKWHTSRQML
RPQFVKDRVSDLECFESHIKTLFKAMANGGALEGEHQHVELSAINGKRFE
ITDLFFRFSLDVATDFLLGYDVKSLSTPHAEFAEAFNEVQHVQSTITRSG
PAQALVPKGSYYRGLKVMDNFINPFIDRALRLSPDELASKTKSDHGYTFL
HELASFTRDRKVLRDQIVAVLLAGRDTTAATLSWTIYELGRHPECVKRLR
QEIAEVVGFGRTPTYADLKSMKYLQNVMHETLRLYPAVPFNVRLALHDTT
LPRGGGPDGTLPVPVLKDTPIGYSTLLMQRRRDLYPPVSENFADPDVFSP
ERWFHWQPRPWQYVPFNGGPRICIGQQFALTEMGYVLVRMFQQYERVVSY
MDEIDGGNPTIKADIVMQPGDGVIVAFWEGDNEKI*
>CYP539A3 Fusarium graminearum FG01284.1
AACM01000065 FGcontig1.65_scaffold1
MGVVEALLEQVTLKTTLVILFVSYCIYSIICRIDEHRRIRRLGHYGPHMK
TYAPWGLGIVARFVVSTVKHQNLATWRDDMFGAENSWTVETRLLGVRTIF
TADPANLKAILATQFVDYGKGKPFHAEWKDFLGDSIFTTDGAPWHASRQL
IRPQFTRDRVSDLHCFEAHMQTLFKAIANRGPLHGEDQPVPTEGLDGKVL
DISDLFFRYTLDVATEFLLGWDVKSLTTPRQEFAEAFNDVQRIQNIVART
GKLRHIIPRYKFWKGLKTVNHFINFYIERALRLSPEELNSKTKDDHSYTF
LHALAGFTRDRKVLRDQIIAVLLAGRDTTAATLSWTLYELGRYPNAVKRL
RSEILSTLGSERTPTYDDLKSMSYLKAVLNETLRLYPAVPFNVRLALKDT
TLPRGGGPDGSEPLPVLKDSPVGYSTLVMQRRSDLYPPISDTFADPQIFS
PERWAHWHPKPHDYIPFNAGPRICIGQQFALTEMSYVLCRLFQKYERVES
RMKDIDGGEPLLKADIVLSPGQGVNVAFWEAKK*
>CYP539A4P Aspergillus nidulans AN5478.1
PSEUDOGENE
LSAKGIDCAVRAVYQLLNYNFVEWTQNVLEENGRTVELHLAGARLVLTDDCENVKAIMFS
GKGKFTHEVFASVFGDSVFGS
LNRCGTRSPPSAKALKDLVFLKYVIRETLRLY
AMQDPVAITITSALFELVRHPEIAQRLREEVVRV
VVGFNIREAQRDTTIPIGGGPNGDLLITILKGQHVAYSVIGLQRRPDIVGPDADNWRPDGY
310339
MGTFHWAPQTWEFIPFNHGPRICLGRVFGYFQMEYTLCRIFQHFERVE
LHEPRVQRIKVELNTKMAYPVNCSFHRAVY*
>CYP539A5 Nectria haematococca
fgenesh1_pg.scaffold_2000110
Necha1/scaffold_2:391800-393499
78% to 539A3
This gene model seems correct
MGLVEAFLEQASFKAVFLIAAAFYTIYYIGCRIDEHIRIRRLGRYGPYLRTYAPW
(1)
GLDRLVKFVYATAKH
RNMEVWRDTIFGAHNSWTVESRFLGVRTIFTADPANVKAILATQFGDYGKGEPFHREWSDFLGDSIFTTD
GAKWHASRHLIRPQFTRDRVSDLHCFESHVQTLFKAIANGGPLLGEAQVVDMDSVDGKVLNISDLFFRFT
LDVTTEFLLGSDIKSLT (2)
NPRQEFAEAFNEIQHIQNIVARTGKLRHFYPKPRFWHCLNVVDNFINKYIDRA
LRLSPEELASNSKDDHGYTFLHALAGFTRDRKVLRDQIIAVLLAGRDTTASTLSWALYELGRYPHAVAKL
RAEILSTVGPDETPTYEHLKNMPYLKSILNETLRLYPSVPFNVRIALKDTTLPRGGGPDGTEPLPVLKDS
PVAYSTLVMQRRSDLYPPVSEKFADPQIFSPERWAHWFPKPHDYIPFNAGPRICIGQQFALTEMSYTLCR
MFQRYERAVSYMKEIDGGKPLLKADIVLSPGQGVKVAFWEATRA*
>CYP539A6 Mgr018 Mycosphaerella graminicola
54% to CYP539A1 N. crassa
MLVALIDRVWANTVLYLIGVATAWSIRQYSSPLISSGLLVGATVVYLMNFIGHVEQERKIENLGGHTAQLRTFSPWNISVLFQGITYARKSMNHIFWGLIFTRAGAGNHSHTAEVQAAGQRIIFTRDEENIKAILATQFQDYGKGPQFRKDWGHFLGLSIFTTDGEIWHNSRTLLRPQFIKDRVSDLHTFEHHIQELLPMLAGDHDGATVRLDDLLFRYTLDAATGFLFGSGVGSLKNGETEFALAFAEAQRVQSIIARAGPMNGLVPRKSFNEAVKILNEFTGRFIDE
(0?)
ALALPQHELEKKTKSDEGFTFLHALAGYTRDRTILRDQLVAVLLAGRDTTACTLSWLFYELSTHPEIVKKLRQEILSVVGPNEEPTYDHLKAMRYLTHTMNETLRLYPVVPYNVRVALKDTTLPHGGGPDGLQPIGITEGTPIGYSTFVMQRREDIYPSAKEGFPDPKQFVPERWEGWTPKAWTYIPFNGGPRICIGQQFALTEMAYTVVRILQTYDTIISKNEKFPGTKADIVLQPADGVFVAFKKASRS
>CYP539A7 Fusarium oxysporum
88% to CYP539A3
FOXG_00101
MGVVEALLEQISVKTTFIVLFVAYGVYSIICRIDEHRRIRRLGRYGPQLKTYAPWSLDLVARFVRSTVKHNNLASWRDGI
FGPLNSWTAEARLLGVRTIFTADPANLKAILATQFVDYGKGQPFHAEWKDFLGDSIFTTDGPSWHASRQLIRPQFTRDRV
SDLHCFEAHMQTLFKAIANRGPLRGEGQLVDMNNTDGKVLDISDLFFRYTLDVATEFLLGWDVKSLTTPKQEFAEAFNEV
QHIQNIIARVGKLRHIIPKYRFWRALNTVNHFINFYIERALRLSPEELASKTKDDHSYTFLHALAGFTRDRTVLRDQIIA
VLLAGRDTTAATLSWTLYELGRYPNAVKKLRAEIISTLGTERTPTYEDLKSMSYLKAVLNETLRLYPAVPFNVRLALKDT
TLPRGGGPDGSEPLPVLKDSPVAYSTLVMQRRSDLYPPTSDTFADPQIFSPDRWAHWHPKPHDYIPFNAGPRICIGQQFA
LTEMSYVLVRLFQKFDRVESQMKDIDGGEPLLKADIVLSPGQGVKVAFWEAQN*
>CYP539A7 Fusarium verticillioides
97% to CYP539A7 Fusarium oxysporum = ortholog
FVEG_01415
MGVVEALLEQISVKTAFIVLFIAYVVHSIICRIGEHRRIRRLGRYGPQLKTYAP
WSLDLVVRFVRSTVKHNNLASWRDGIFGPLNSWTAEARLLGVRTIF
TADPANLKAILATQFVDYGKGQPFHAEWKDFLGDSIFTTDGPSWHASRQLI
RPQFTRDRVSDLHCFEAHMQTLFKAIANRGPLQGEGQFVDMNNTDGKVL
DISDLFFRYTLDVATEFLLGWDVKSLTTPKQEFAEAFNEVQHIQNIIARVG
KLRHIIPKYRFWRGLNTVNHFINFYIERALRLSPEELASKTKDDHSYTF
LHALAGFTRDRTVLRDQIIAVLLAGRDTTAATLSWTLYELGRYPNAVKRL
RAEIISTLGTERTPTYEDLKSMSYLKAVLNETLRLYPAVPFNVRLALKDT
TLPRGGGPDGSEPLPVLKDSPVAYSTLVMQRRSDLYPPISDTFADPQIFS
PERWAHWHPKPHDYIPFNAGPRICIGQQFALTEMSYVLVRLFQKFDRVES
QMKDIDGGEPLLKADIVLSPGQGVKVAFWEAQD*
>CYP539A8P Aspergillus terreus
note: best matches are CYP539A seqs but
no I-helix motif LAGRDTT is found suggesting a
probable pseudogene
C-term half is 48% to CYP539A2
CYP539J1 is 3 kb upstream
ATEG_08168.1
MRCVYELATHGFHEYVRDILATKPGRTIEFHILDKRMIVTDNPENIKEMMSVQFDTFGKGDLTHHIFRNCFRGSIFGSEG
AEWAAHRAQLKPHVGTMRPSDPEKLEKHFLQMLKKNIPDD
GSPVEVYDMLDM
MLLETVIDIFVDPSKDPEYKHIDPRPFV
NGVNALLKINTFRVLLGNVSRLVSDTLVARASTQALHEYLGSHVRWIRKLQSSNYGEKP
KKEWTLMETFASEPLPDSDPVGMI
WVIYELGRRPEIVDKLREEIIATIGDDINTLPTDAQLRSMKYLQNIIKEAMRMYHPF (0)
LTFAVGFNIRCPNKDTVLPTGGGPNGDQPLPILRETFI (1)
VVNIMGLHRRADIVGA
DTDVFRPERWDTFKPGPWEYMPFHRGPRNCLGMAFGQYAMAYLIVRLYQLYD
ILPADNIVQRIKVEMNTKVSHP VNMRFYPRQSVSSPRLQKDEVLL*
>CYP539A9 Mycosphaerella fijiensis
64% to CYP539A6 Mycosphaerella graminicola
estExt_Genewise1.C_13960
MILHILDRLGWLTLLYSSITYCTYQLRNLIPEKLCYALLLLLTIVYLKKVIHHLDQESRIRRLGKRAPSVRTPYPFNLGV
MFQALYYFSQHRNHEFWWNLFKKGNPNRPYTVEALTLGGRLVFTADEENIKAILATQFSDYGKGPQFRKEWKDFLGLSIF
TTDKELWHNSRQLLRPQFIKDRVSDLQKFEHHVQILLPLMAGSHNGATVRLDDFMYRFTLDAATDFLFGTSVGSLLNGEA
EFAQAFAEVQGVQAIIARSGPLASLYPKKKFHEALSVMNKFTDRYIDQALQLPKEELEKKTKSDEGYTFLHAIATYTRDR
QVLRDQLVAVLLAGRDTTAVTLSWLFYELSLKPEIVKKLRQEIVSHVGLHREPTYDDLKSMRYLQHTLNETLRLYPVVPY
NVRVALEDTTLPHGGGPDGMEPVGIAKDTPIGYSTFVMQRRADIYPPESDKFPHYLKFAPERWDHWTPKSWTHIPFNGGP
RICIGQQFALTELAYTVTRILQTFERVECRMDEYPGTKTDIVLQPAKGVYVAFVKAGSV*
>CYP539B1 Magnaporthe grisea MG06973.4 45% to CYP539A1 AACU01000620 cont2.1289
MFGGLVEVRPLPLAGFLLGVYVAAWFIQAALMDYRIAKRGGGGVKAPRVA
SNMITAGIWFFWAGWRQMRNDLLSLYNSVYDKHGTPESPNCVEITLTTPG
VRFILTREPEHVKTILTSKFSDFGKGYHFHKIWSPFLGDSIFTTDGQLWH
DSRSLIRPMFIKEKVRDLDIFDRWTNEMINLLPPPGQSVDIANLLYRMTL
DVTTDFLLGESVNALRDEHNEFAYYFNEIQRIQMMLTILVPAAPFLPRHR
YYAGIKYIEKFMAPFIEQALALPPDELEKLSKTDKDFTFLHNIARYSRDR
KVIRDQIMAVLLAGRDTTAATLSWTIYELCNKPEVVKRLRQEILRVVGPF
GNKPTYENLKELKYLTHIINETLRIYPAVPYNIRAALEDSSLPSPDGKPS
IAVLKGDIVVYSALSMQRRKDIYPEVSETFPDPAVYCPERWEHWTPKPWT
YVPFNGGPRICVGQNFAMTEMAYVLVLIFQKFDRIEYCGDWDAQYHKAEI
VGAPGHGVPVTLYPAVDDQVKE*
>CYP539B2 Aspergillus nidulans AN4858.1 53%
to 539B1 49% to 539A1 52 clan
revised 7/18/07
MSQMDPKIYLLLFLSPVLAFSGLILIYILTRPIRLFLYDRRFYLKGGIHAPMIPRDIIS (1)
VTRFFFAVVKAQNEHRLYEFFKKSLEHGD
PASPNCVESNIFGSFRVIQTREPEHLKAVLTGKFADFGKGELFHKLWIPF
LGDSIFTTDGKEWQGSRNLIRPMFIKDRISDLDIFERKTQT
MLSLYSPCG
EPTDVVDLFYRMTLDAITEFLLGKGINSLENPQADFALAFADVQRIQTLL
TMLGPAQYLYPRGRYNQGLKVINDFVWPFVHDTLGFQADDLKSSDKSFTF
LHALANYTRSPKTIRDQVVSILLAGRDTTAATLSWAFYELSHYPEAYSKL
RAEILDKVGPTRAPTYDDLKNMPYLRHTINEVLRLYPAVPYNIRFALTDT
TLPIGGGVNGDLPITILKGDAVAYSTYAMQRRADLYPPVSEKFADPAIFS
PERWEVWSPKPWHYVPFNGGPRICIGQNFALAEMGYTIVRILQRYERIEY
VGDWERQFHKSEIVGTPGMGVKLRLYEARKP*
>CYP539C1 Magnaporthe grisea MG08234.a 42% to 539A1 top half AACU01000307
cont2.1540
2 P450s fused
MIQKYGGHAVKFSFSNSPLDNIFGLRFAWEFYRHGRRDEYLKFTHRSFAQ
SGAGRANPYTYEVNLGGVRTIWTADPENIKAMLGSQFEDYGRGKAFQSRW
HDLLGTGIFNADGREWHDSRHRLRPLFNRQRVSNLDSFERQIQIMINRHL
GGGRTVDLKDVISRFALDAIGDYAMGFQVNALADRKNDFLDALERIKTIQ
NIKECAGPLSWLVPTPGFKRDLKVLDDFMEPLIEHAASLPQSVLDEMEKT
DHGWTYVKACASVSRDRHFLKYELMSVILAGRDTVSGTLVWTFLELVKRP
DLMADLRREIENTVGIGRDAPRPTHDDLRSMRLVKNTLNETLRLYPTVSL
NLRTALRDTSLPRGNDHDGNKPVGLAEGTPVIFSSHILQLSPETYEQSPP
GTSPPHVFDPYRWEEWKPKPWTYIPFGGGPRICIGQEFALAEMAFLLVRL
LQNYSRLEMRCEMRGNSDEGWERPNGSASIVEQFM
>CYP539D1 Aspergillus nidulans
AN3917.1 52 clan 53% to 539A1
MIEELVSKTTPGQAVVYLLGAFFLACLARKIQVQWQLSRLGSRAPKIPFR
LPYGLLIPSISRNSHADRRLSSAMDFIYKSMQANKSDQDLEYFTDVMRNA
KGAPLAEDKKTVELDAGISSRIIFTRDPENIKAILTGQFSDYGKGESFHR
DWREFLGDSIFVTDGEQWSASRHLIRPMFVRDRLVDTEIFEKHVQHLIPL
LAGNNESKIVD
VTSLFFRYTLDAATNYLLGQGTDSLQNPETEFAEAFRYV
QRRQAQYFRLGVFKFVLSRTEFRRQLKVMDDFIKPYIDRVLAMSPAELDQ
KLSKSDTFLHALARFTRDRRTLRDQLVAILLAGRDTTAATLSFCLFELAR
NPEVTAKLREEIASRLGLGASAQKPSYTDLKEMKYLNAVLNESMRLYPVV
PFNVRFSLKDTTLPRGGGPDGLAPVAVRAGTRVVYSTMIMQRSPENYDPP
SAPNYFDPAQWNPERWLSGWQPKPWQFIPFNGGPRICIGQQFAMIEMGYT
VVRILQAFERIQAVPEAGKSVVEDPRLRFEVTLTPASELNCVFVRDGEGR
EDEKISR*
>CYP539D2 Aspergillus fumigatus Af293
GenEMBL
XP_750735.1 also EAL88697.1
71% to 539D1
MIEELLAQIHSGWAALYVLGALFFACLIRKAQVSMEISKLGYRAPRIRFYLPWAIDFLYEASKANEDGTD
HVFLHQAILNAKGATQLDCVKTAELNGGITRRVILTKDPENIKAILTGQFADYGKGEEFHEQWKDFLGDS
IFATDGELWSRSRHLIRPMFVRDRIVDTEIFEKHVQNLIPLLEGSNSPSGSKAVDVGSLFFRFTLDAATD
YLLGQGTNSLHNPETRFAEAFGYVKHRQSEIFRLGDGISMFSFIVAKRKFRRELKVMDDFFQPYIKRALS
LTPSELDQKISKRETFLDALARFTRDPRVLRDQIVAVLLAGRDTTAAVLTFCIFELARNPDVVAKLREEI
SARLGLGPSAQKSSYNDLKEMKYLNAVLNETMRLYPPVPFNVRYSLRDTTLPRGGGPDGLSPVGVRANTR
VIYSTMIMQRSAENYDPPGSPNYFDPEKWLPDRWLSGWQPKPWQYIPFNGGPRICLGQQFATIEMGYTVV
RILQAFERIHAMPANGKERVEDPVLKFEVTLSPGSELNCVFVREGEDTLPLKDG
>CYP539D3 Aspergillus niger
e_gw1.4.261.1|Aspni1
67% to CYP539D1
MLEYLVGQMSPMKASACLVGIFLIACLVRKFQVSLEVSRLGLRAPRIRFRLPYALDNVYGYVMANSRGEDLTHWQNLMET
AHGASAIDHVQTAELDFGISNRAIVTKDPENIRALLTGQFADYGKGEPFHHDWKEFLGDSIFVTDGELWSRSRQLIRPMF
TRDRIVDTEIFEHHVQHLIPLLAGTKSNKVVDVTPLFLRYTLDAATAYLFGDGTNSLQNPATSFAEAFSYVQHRQSEIFC
YGYTSTNNRSISPFNPILSRTKFRQELKKMNDFMAPFIQRALSLSPEELDTSLSKQETFIHALARFTRDPKVIRDQLTAI
LLAGRDTTATTLAFCFFELARNPSVVAVLRSEIASRLGLGPSGRKPTYTDLKEMKYLTAVLNETNRLYPVVPFNVRYALK
DTTLPRGGGADGNGPVGIRANTRMIYSTMMMQRDPAHYPPPGSKNYFDPGKWVPERWTGDWVPKPWHFIPFNGGPRICLG
QQFAMIEMGYTVVRILQVYESLRAMPPAGKDKVEDPMLRFKITLNPGSELNCVFE*
>CYP539D4 Uncinocarpus reesii
57% to CYP539D3
UREG_01046.1
MLEELASRFSPAQAALVAFGLFAVFLFILDCRIDWRIRKLGAQSPRIKSYLPLGFDFIYRVMKAGSQSKDLEFWTELAKE
LPSHGPGPVGTYEVKFRCYGRSVFTTDPDIIKTVLTGQFADYGKGKRFHEEWRDFLGDSIFATDGELWSKSRQLLRPMFA
RDRIVDTEIFEKHIHKLIPLLSGDLNQDGSKTVDVGPLFFRFTLDAATDYLLGHSVDSLDNPKTTFAEAFQYVLHRQSVL
FRAGPISPLMSRKLFHENLKKMDDFMQPFIEQVRALTPEELDHKLSKKDTFLHALARFTRDPTVLRDQLVAVLLAGRDTT
AATLSFCLFELSRHPAVVQKIRHEIASVCGTRKPTYSELKEMKYLNAVLNETMRLYPVVPFNVRHSLVDTTLPRGGGPDG
LSPIGVPADTRIIYSTMAMQRRRDLYPAPPLPGEKPSQPYFDPLLFHPERWTSGWQPKPWHFIPFNGGPRICLGQQFATI
EMAYTITRILQHFTGIVGVGTPPPGTDPKFKFDVTLSPGQRLDCVFVKEGN
>CYP539D5 Coccidioides immitis
85% to CYP539D4 Uncinocarpus reesii
CIMG_01103.2
MLEELVTAVSPGQAVLIAFGLFATFLFILDLKIDWRIQKLGPQAPRVRTYLPLGADFIYRAMKAAGKQKDLEFWTKMTEV
PKYTGPGRLSTFEVKFSCYSRSLFTIDPDNIKAVLTGQFADYGKGRRFHEEWRDFLGDSIFATDGELWSKSRQLIRPMFS
RDRIVDTEIFEKHIHKLIPLLGGGANQDGSKVVDVGPLFFRFTLDAATDYLLGQSVDSLDNPKTTFAESFQYVLHRQSVI
FRSGPLSPLLSRKLFHENLKKMDDFMQPFIEQVRALTPEELDHKLSKKDTFLHALARFTRDPTVLRDQLVAILLAGRDTT
AATLSFCIFELSRHPAVVQRLRNEIETVCGNRKPTYSELKEMKYLNAVLNETMRLYPVVPFNVRHALVDTTLPRGGGSDG
QSTIGVPADTRIVYSTMAMQRRRDLYPPPPVPGEKTLQPYFDPLLFHPERWLSGWQPKPWHFIPFNGGPRICLGQQFATI
EMGYTVTRILQHYPEIIGVGAPKPGTDPKFKFDVTLSPGQRLDCVFVKKEE
>CYP539D6P Histoplasma capsulatum G217B
pseudogene
68% to CYP539D4 Uncinocarpus reesii
HCB02885.1
Second half of this model is like annexin
(deleted)
ABBT01000091.1 Ajellomyces capsulatus G217B
86855-88176
GQRFHEEWREFLGDSIFATDGELWSRSRRLIRP
MFARDRIVDKENFEKHIQTLIPHLKGNNENPGKGTIVDVATLFFCFTLVAATDYLLGQSVDGLDDPKTIFAESFQYVLHRQSNS
CLPLCRPIRPLLSGKGFRLNLKKMDDFMQPLIDEVLPLSSEEFDKKLSK
KHTFLHALAHFTKDHKVIHDQLVAILPAGRDTAATLCFCLFELSHNPTVVAPEVLDRLGTSRKPSY
SDLKEMKFLTAVLNETLRLCPVVPLNV &
LPRGGGPDGHSSIGIPNNTRIFYSTTNMQRRRDLYDTPPLAPGNAGSDEKWPIPYFEPLL
WIPERWTDGWQPRPWHFIPFNGGPRICLGQPFAMLDMGYTVSRILQNFSEIRAGGAGPAGQDQPFK &
FDVTLSPGEELNMVFVEAGKETG*
>CYP539D6P H. capsulatum G186AR
Supercontig 8: 874979-876322 +
88% to CYP539D6P Histoplasma capsulatum G217B
GQRFHEEWKEFLGDSIFATNGELWSRSRHLIRPMFARDRIVDTENFEKHIQKLIPHLEKN
NEKPGEETIVDVAALFFCFTLSAATDYLLGQIVDSLDDPKTIVAESFQYVLHHQSNF
CFPLCRPISPLLSSKGFRLNLKKMDDFMQPL
IDEVLPLSSEELDKKLSK
KHTFLHALVHFTKDRKVIHDQLVAVLPAGRDTAATLCFCLFELSHNPTVVAPLHTEVLD
RLGTSRKTSCSDPKEMKYLTAVLNEALRLCPVVPLNVCHALTDTTLPRGGGPDGHSSIGI
PNNTRIFYSTTNMQRRRDLYDSPPPAPGNAGSDEKRPIPYFDPFPWIPERWTAGWQPRP*
HFIPFNGGPRICLGQPFAMLEMSRILQNFNEIIADG
AGPAGQDPPFKFDVTLSPGEELNMVFVEAGQETG
>CYP539D7 Aspergillus clavatus
68% to CYP539D3, one frameshift = &
ACLA_082210 revised
MIEDLIAQMPLGMATLYLLGAFFLICLLRKAQVSTQISMLGYRAPRVGFRLPYAIDFIYKALKAHNIHEDLEFWHQAIRT
AKGASKIDHVKTAEVDGGVSNRVILTKDPENIKALLTGQFADYGKGEPFHREWKEFLGDSIFATDGELWSRSRHLIRPMF
ARERIVDTEIFEKHVQHLIPLLAGSDAPGGSKKVDVGSLFFRFTLDAATDYLLGQGTDSLQNPETRFAEAFRYVQSRQSE
LFRLG (2)
VFSFILSKRKFRQELKVMDSFLQPYIDRVLSLTPSELDQKLTKQESFLDALARFTRD
PRVLRDQLVAVLLAGRDTTAATLSFCVFELARNPHVVAKLRQEIDARLGLGPKGRKPTYNDLKEMKYLSAVLNETMRLYP
VVPFNVRYSLRDTTLPRGGGPDGLSPIGVRANTRIIYSTMIMQRSAENYDPPGSPTYFDPEKW
(&)
PERWLSAWQPRPWHFIPFNGGPRICIGQQFATIEMGYTIVRILQAF
ESVCALPANGKNRVEDPVLRFEVTLSPGSELNCVFVREGEGQRTGH*
>CYP539D8 Aspergillus fumigatus
supercontig 6 1986238-1987987 (+) strand
MIEELLAQIHSGWAALYVLGALFFACLIRKAQVSMEISKLGYRAPRIRFYLPW
()
AIDFLYEASKANEDGTDHVFLHQAILNAKGATQLDCVKTAELNGG
ITRRVILTKDPENIKAILTGQFADYGKGEEFHEQWKDFLGDSIFATDGELWSRSRHLIRP
MFVRDRIVDTEIFEKHVQNLIPLLEGSNSPSGSKAVDVGSLFFRFTLDAATDYLLGQGTN
SLHNPETRFAEAFGYVKHRQSEIFRLG (2)
MFSFIVAKRKFRRELKVMDDFFQPYIKRALSLTPSELDQKISKRETFLDALARFTRDPRV
LRDQIVAVLLAGRDTTAAVLTFCIFELARNPDVVAKLREEISARLGLGPSAQKSSYNDLK
EMKYLNAVLNETMRLYPPVPFNVRYSLRDTTLPRGGGPDGLSPVGVRANTRVIYSTMIMQ
RSAENYDPPGSPNYFDPEKWLPDRWLSGWQPKPWQYIPFNGGPRICLGQQFATIEMGYTV
VRILQAFERIHAMPANGKERVEDPVLKFEVTLSPGSELNCVFVREGEDTLPLKDG*
>CYP539D8 Neosartorya fischeri
95% to CYP539D8 Aspergillus fumigatus = ortholog, 79% to
CYP539D7
NFIA_054110
MIEELLARIHPGRAALYVLGALFFACLIRTAQVSMEISKLGYRAPRIRFCLPWAIDFLYGASKANDDGTDHVFLHQAILN
AKGATQLDCVKTAELNGGIARRVILTKDPENIKAILTGQFADYGKGEEFHEQWKDFLGDSIFATDGELWSRSRHLIRPMF
VRDRIVDTEIFEKHVQNLIPLLEGSNLPSGSKVVDVGSLFFRFTLDAATDYLLGQGTNSLHNPETRFAEAFGYVKHRQSEIFRLG
(2)
MFSFIVTKRKFRRELKVMDDFIQPYIKRALSLTPSELDQKISKRETFLDALARFTRDPRVLRDQIVAVLLA
GRDTTAAVLSFCIFELARNPDVVAKLRKEIGARLGLGPSAQKPSYNDLKEMKYLNAVLNETMRLYPPVPFNVRYSLRDTT
LPRGGGPDGLSPVGVRANTRVIYSTMIMQRSAENYESPGSPNYFDPEKWLPDRWLSGWQPKPWQYIPFNGGPRICLGQQF
AAIEMGYTVVRILQAFERIQAMPANGKERVDDPVLKFEVTLSPGSELNCVFVRKGEGTLPLRED*
>CYP539D9 Aspergillus flavus
75% to CYP539D7 Aspergillus clavatus
AFL2G_09153
MIEELLHQMTPGKASVLFLGVFIVLCLVRKVQVSMHIKRLGGRAPQIQFRFPY AMDFIYNSLNANRAHRDLEFFGNAIKT
AKGASQIDSPKTAEVSAGISSRFIFTRDPENIKAILAGQFADYGKGEPFHNDWKEFLGDSIFVTDGELWSRSRHLIRPMF
VRERIVDTEVFEKHVQHLIPFLSGGNSPAGSKIVDVGPLFFRYTLDAATDYLLGQGTDSLQNPTTSFSEAFGYVQHRQAD
LTRLG IFKFLLSLREFRRNLKIMDNFIQPYINRVLSLSTAELDQKLSKQDTFLDSLARFTRDPRVLRDQLVAILLAGRDT
TAGTLSFCLFELARNPQVVAKLRQEIESRLGVGAKGRKPSYIDLKEMKYLNAVLNETMRLYPVVPFNVRLALRDTTLPRG
GGPDGLSPIGVRADTRVLYSTMLMQRNPENYDAPGSPGYVDPEKFHPERWLSGWQPKPWRFIPFNGGPRICLGQQFATIE
MGYTVVRILQAFREIKAFPVSGKSVVEDPVLRFEVTLSPGSELNCLFVPEEASPTK
>CYP539D9 Aspergillus oryzae
Supercontig 5: 1308953-1309825 (+) strand
100%
to CYP539D9 Aspergillus flavus
MIEELLHQMTPGKASVLFLGVFIVLCLVRKVQVSMHIKRLGGRAPQIQFRFPY ()
AMDFIYNSLNANRAHRDLEFFGNAIKT
AKGASQIDSPKTAEVSAGISSRFIFTRDPENIKAILAGQFADYGKGEPFHNDWKEFLGDSIFVTDGELWSRSRHLIRPMF
VRERIVDTEVFEKHVQHLIPFLSGGNSPAGSKIVDVGPLFFRYTLDAATDYLLGQGTDSLQNPTTSFSEAFGYVQHRQAD
LTRLG ()
IFKFLLSLREFRRNLKIMDNFIQPYINRVLSLSTAELDQKLSKQDTFLDSLARFTRDPRVLRDQLVAILLAGRDT
TAGTLSFCLFELARNPQVVAKLRQEIESRLGVGAKGRKPSYIDLKEMKYLNAVLNETMRLYPVVPFNVRLALRDTTLPRG
GGPDGLSPIGVRADTRVLYSTMLMQRNPENYDAPGSPGYVDPEKFHPERWLSGWQPKPWRFIPFNGGPRICLGQQFATIE
MGYTVVRILQAFREIKAFPVSGKSVVEDPVLRFEVTLSPGSELNCLFVPEEASPTK
>CYP539D10 Aspergillus terreus
76% to CYP539D9
ATEG_05807.1
MIEEFITQMSPGRAALCFLGALVVLFTLRKMQVSMKIARLGGRAPQVRFYLPYAMDFIYRSSKANREHRDLEFFTEAMRT
AKGAAALDNPKTAEVNAGMAARVIFTKDPENIKALLTGQFADYGKGESFHQDWREFLGDSIFATDGELWSRSRHLIRPMF
VRDRIVDTEIFEKHVQHLIPLLEGSSSPTGSKIVDVGELFFRFTLDASTDYLLGQGTDSLQNPETEFAEAFRYVQHRQAL
FFRMGVFGPLLSRKKFREQLKVMDDFIQPYIDRVLSLSTAELDQKLSKKETFLDALARFTRDPRVLRDQLVAVLLAGRDT
TAGTLSFCLFELSRNPEIVAKLREEIRSRVGLGANGQKPTYNDLKEMKYLNAVLNETMRLYPIVPFNVRFSLRDTTLPRG
GGPDGRAPIGVLEGTRVIYSTMIMQRSPEFYPPPGSPNYFDPQKWHPERWISGWQPKPWQFIPFNGGPRICIGQQFATIE
MGYTVVRILQAFEQVQGIPAAGKNRIEDPVLQFEVTLSPGSELNCIFVRDGEGIKESETG*
>CYP539E1 Fusarium graminearum FG08005.1
AACM01000323 FGcontig1.323_scaffold5
MDEIGPDFPFKATPKAVPATLKIDHDCGVKITTSPAINNPPLPADGPGNE
TFSNGLLISLLILVPTCTVWKLGGRFKTTVFFAVITTLPILITFCAITSA
TAPCTNERVKCPGLPVEHYLTFHKEEDQVKYRGRNKVPMETFMRKYFDGD
ADFNGDVLEVLEYRHDWASFRFTWELFRYIIVNFVTDVTAKYGLRWFKIW
KYFLASATTSSRQGSATCYQITLVKNINSVRRIDGVSTQFALSTALEASK
KAGRAVFPANNPSR
P450 STARTS HERE
LQPVFNRERISDLECVERHVQNLLPLLDTEGQTAEI
KDLFLRFTLDVSADFTLGVDLDTLKRPL
NRFAESFERLRHWKIQKERSNP
FKFLVLRSRYQADLDYIESFMDPIIMETVNEIKAEEAGETPHKKDSGFNL
LGASAEVSTNRRFLRDELLTALFAGRDNTAMAFTWILYELAQHPDVVRDM
RREIDAQIGLNSEPGYKTLKDMRILSNIINETLRLYPPVPLNTRAC
110308 LKDTSLPRGGGPLGNDPIGVLKGTGIINSNCL 110213
110192
EAYSTVPEGFPPADEWCPKRWNNWFPKPWAFVPFHGGPRFCLGQQLVLVEMSYTLVQLFQ 110013
110012 RFSRFELRIDE (0)
PRMVTEIALFPRREVRVAFVR*
>CYP539F1 Aspergillus fumigatus Af293
GenEMBL
XP_747469.1
51% to
539B2, 50% to 539A3, 39% to 539C1,
43% to
539D1, 39% to 539E1
probably
needs some revision
MQGNQMTTTTTTILDYLLLLSLSSYLLKTILGNLSSLKEGFTSLWALKIIGCLFLTIVARPIWNILFSSH
TPRDSKLPQIRTFLPLGIDYITRGIIYSAQNKSLVFWEELFRKYHPFQTLEVRLGPQTVIVSRDPQVVKA
LLTTQFGDFGKGERFHTEWREFLGDAIFTTDGDKWHASRALIRPMFTPDRVSNLSTFERHVQKLLRILES
PRHERQPVNVLDLCLRLTMDIATDFLLGQSVDSLSNPTHRFSAAFADVQRIQSWITMAGPLQVFLPKAKY
YEGLKTINSFVDPFITRTLALGRRSFEEMEGSEEEYNFLEGLATFTQDPKVIRDQLISVLLAARDTTAAT
LARTLYELSGHPDVVQRLREEILAQVGTASAPTYADLKNMRYLQAIHKETLRLYPAIPFNMRVALSDTTL
PSGGGPSGTQPVHVKKDTIVAYSPLYMHRSDLYPDAYADGTPFSDPREYHPHRWMYPGSKTADSEKINEG
PWIPKPWTYIPFNGGPRICLGQQFALAEMGYTLVRIFQKYKCLERRMRAEDGGLMRANIVLTPAQEVNVV
FIQSLSTSGAVMLILYRLRS
>CYP539G1
Chaetomium globosum CBS 148.51
NZ_AAFU01000716
partial seq 50% to 539B1
MLQFLINLGLLHTSALVLG
CLSIFFLSRKLLVDYKIRKLGGVRAPVLATNPVT
(1)
GLRFFLWAGYAQTKNRLDHFYRDIFNWATPECPNCVEISFL
GRTRFLMTREPEHIKTILTTKFREYGKGEQFHEAWSPFLGDSIFTT
DGQKWSESRALIRPMFIKDRVRDLEIFDKWA
TTLISKLPASGQTVDVMDLFYRMTLDVTTDFLLGGSVDSLNK (2)
PKHEFVSAFQDVQRIQMLLTIMAYATLIL
PTSPFRALIPTHRYTRGIRTLERFISPFIERTLSLPPSELDPTTNTTTTTTPNKTTTFLH
HLALRARSPQAIP*KIMGGLIAGQPTTAATLTW
>CYP539H1 Fusarium verticillioides
50% to CYP539F1 Aspergillus fumigatus, not
found in the F. oxysporum genome
FVEG_05544
MSDTVISLVDSSIYMLHAAIHHPYRLALYIIVIYFTRRILNRLLVPPP
ISVAPRIPTYLPFGIDFIVWSSYYNSTNQDLKLWSMIFRRYGRGTAPYTAEV
VLGGDRVIFTADHENIKAVLATKFSDYGKGPKFYHDWKEFLGDSIFATDGR
LWQDARGLIKPLFLRQRIEDLAVFEKHTVKLTRMLQGPEGQPIGVDVKD
LFFRFTLDVATDFLFGQAINSLDNPREQFAVAFAEIQRVQRLITVSGPL
QSFVSLKSYHSSLNTINKFMEVFISETLSLERDELEKLTKSDRGYTFLSAL
ALYTRDAKQIRDQLVAVLLAGRDTTAATLSWVLHELSGHPDMVRRLRQEIA
QHVKPGQNPSFAELKAMKYLQAILNETLRMYPAIPFNMRIALDDTSLPR
GGGSDGNQFISVKKDTIIAYTPLVMMRRNDLYPATYNNGDKFPDPNTFD
PERWLHPSVLHTAEKGADASETKASGVNNKEWSPRPWTYIPFNGGPRICLG
QQFALTEMGYTLVRIFQQFARVERRMEPDEMGILSANIVLTPKNGVRVAFFKEEED*
>CYP539J1 Aspergillus terreus
48% to CYP539A6 Mycosphaerella graminicola
ATEG_08167.1
MMLGEAGQFPHMG
ALLLTALFIVYLCRQWTTRQKILRLGGYAPRIPSYVPL (1)
GLDILFTAIRNGRRNKSLETWRGWHSCAPNNGTVEAKVLFERYLLTGDPENIKAILATQF
DDFAKGQLFHDTWSQLLGDGIFSTDGAPWRGSRQLMRPLFAKDRVSDLDVLERHVQKLLR
NVAAKSGQRLDLCDLLFRYTLDAATDFLLGEPVGSLDNDTQEFATAFDHAQYIQMMIARSG (2)
RAHVLIPRASLNKSISTINAFIRP
YIDSALRLQDSTKLVERSEPDYTFLHALAHYTRDPKLIRDQLVNILIAGRDTAASSLS
WVFFELAKQPRVTTKLREEILAQVGFERPTYSQLKDMKYLQ (0)
NVIRETLRLYPIIAF
NVRVAQRDTTLPRGGGPDGLSPVGVLKGTRVFFSSLYMQRRASLYPGDPNPDEFHPERWE
KWQPASWQYIPFSGGPRICIGQQFALTEIAYTIVRLLQSFDRIEPCIEHMEPVLETNISM
KPGTGVPVKLWSAAPVSNEQRVEGSAC*
>CYP540A1 N.
crassa AABX01000009.1 cont3.484 NCU08062.1 (version3)
46350
MSSQTFFLVGDGPSTARGIVVDPKWKLEELKRAVGLAHHIAVPTG (1) 46481
46537
GITFHFDADDEQELKTVEDVLRASGPVACRIDGNPVRDPQGPEGLPIVGS
YYEIFPDHLGNHYRLFRKYGHVIKTTNMGRTNYLTDDPAVALVALAESAYFTKKIT
EEHPLFGIKDNSAIFIGDTETENWRLAHKFLPPAMGPKAVRHYTPLMQEC
VRGSFKIFDELDSRGESWNVYQYMVKLASQTVGKFAMGIDYHHFDAVDTP
VHSLVTNIVKLLALNKKVTARGSWYQQLPFGDPARLREIRQITYGQLAET
IEAAPKSGIENLPLNEAATKASCVADYLLNAVDEKGEHFPKGLILSNMLV
VTGAGYTTTSALLSWCIYCIVTYPKMQDRLLQELIDHGINSETDWDPDLA
HSLPFLDAFLKETQRLHNASFQPGRTTKTDVVLPGGFRLPENVIMIPALY
AIHTNPEHWHDPFRFDPDRWDTEEVKSRHRGAYMPFATGPRSCIGFNFAL
LEIKVLLSELVYRYKFAREGFEAIEYDPEFQLIRPLNLYVTAKRRTEWPAKSSA*
48069
>CYP540A2 Aspergillus nidulans AN8919.1 68%
to 540A1 check introns 505 clan
MRPPTVQCQFYLIGDEPSSAQSVTVDTRWKFEDLQRAVGLVFHVAQPLGT
LSTVDEVLTLANSSSAIGILVDGKPVQSPQGPPGLPLVGSFYEIFPDHLG
NHYRLFRKYGPVIKTTNMGKTIYLTDSPQVAASCFAESIYMTKKITEDHP
LWGVKDNTAIFIGDTETENWRLAHKYLPPAMGPKAVRHYTGLMQNCARKA
LPVFDELDARDESWNVYQYMVKLASQTIGSFSLGKDFGHFASIDSPLHPI
VTNIASLLSLNKKITARGEWYRLLPFGDPARLRSVQHTIYTLLQEAIDEV
AARSASKDAPMSDAALSASCVVDYLLHAVDEKGEHFPTGLILANMLIVTG
AGFTTTSALLSWLIYCLVTYEGTQDRLYSELVEYGIVGPSGEPNKTTWTP
DLAHSLPYLNNFVKETQRLHNASFQPGRTTKTDVVLPGGYRIPENSVIVP
ALYAIHTNPSIWHDPFRFNPDRWDSDEVKNLHRCAYVPFATGPRGCIGFN
FALLEVKIILAELVSRYEFVRDGVESIEYDPEFQLIRPLNFYVRAKRRS*
>CYP540A3 Aspergillus oryzae
GenEMBL
BAE57130.1
84% to
540A2, 56% TO 540B9
MKCQFYLVGDDIATAQSILVDSRWKFEDLQRAVGGIFHVALPTGISFHTSENETLSSVADIISASSSPIG
LRIDGNAVQTPQGPKGLPLVGSFYEIFPDHLGNHYRLFRKYGPVIKTTNMGKTTYLTDDPQVASVCLAES
AYMTKKINENHPLWGVKDNTAIFIGDTETENWRLAHKYLPPAMGPKAVRHYTGLMQNCARKSLPVFDELD
GRDESWNVYQYMVKLASQTIGSFSLGKDFGHFDSVDSPLHPIVTNIANLLSLNKKITARGEWYRYLPFGD
PARLRHVQHTIYTLLQEAIDEVAGSGIADAPMNEAALSASCVVDYLLHAVDDKGEHFPQGLILANMLIVT
GAGFTTTSALLSWLLYCLVTYVGTQDRLYAELVEHGIVGPSGERNQTTWTPDLAHSLPYLDKFVKETQRL
HNASFQPGRTTKTDVVLPGGYRLPPDSVIVPALYAIHTNPKTWRDPFRFDPDRWDTEEVKGRHRCAYIPF
ATGPRGCIGFNFALLEVKILLAELVSRYEFVRDGLEAIDYDPEFQLIRPLNFYVRAKRRV
>CYP540A3 Aspergillus flavus
99% to CYP540A3 Aspergillus oryzae
AFL2G_09274
MKCQFYLVGDDIATAQSILVDSRWKFEDLQRAVGGIFHVALPTGISFHTSENETLSSVADIISASSSPIGLRIDGNAVQT
PQGPQGLPLVGSFYEIFPDHLGNHYRLFRKYGPVIKTTNMGKTTYLTDDPQVASVCLAESAYMTKKINENHPLWGVKDNT
AIFIGDTETENWRLAHKYLPPAMGPKAVRHYTGLMQNCARKSLPVFDELDGRDESWNVYQYMVKLASQTIGSFSLGKDFG
HFDSVDSPLHPIVTNIANLLSLNKKITARGEWYRYLPFGDPARLRHVQHTIYTLLQEAIDEVAGSGIADAPMNEAALSAS
CVVDYLLHAVDDKGEHFPQGLILANMLIVTGAGFTTTSALLSWLLYCMVTYVGTQDRLYAELVEHGIVGPSGERNQTTWT
PDLAHSLPYLDKFVKETQRLHNASFQPGRTTKTDVVLPGGYRLPPDSVIVPALYAIHTNPKTWRDPFRFDPDRWDTEEVK
GRHRCAYIPFATGPRGCIGFNFALLEVKILLAELVSRYEFVRDGLEAIDYDPEFQLIRPLNFYVRAKRRV
>CYP540A4 Aspergillus niger
fgenesh1_pg.C_scaffold_1000410|Aspni1
85% to CYP540A3
MQCHFYLIGEAVATAQCLEVDTLWKFEDLQRAVGGVFHVVQPTGISFHASSNDTLKTVSEVLAAATSTSPVGLRIDGNAV
QAPQGPPGLPLVGSFYEIYPDHLGNHYRLFRKYGPVIKTTN MGKTIYLTDDPQVAAACFAESAYMTKKINSDHPLWGVKD
NTAIFIGDTETENWRLAHKFLPPAMGPKAVRHYTGLMQECARKSLPVFDELDVRDESWNVYQYMVKLASQTIGRFSLGKD
FGHFDAVDSPLHPIVTNIASLLSLNKKITARGEWYRHMPFGDPARLRHVQHTIYSLLQEQVDTVTAESCSTDAPMADAAL
SATCVVDYLLHAVDETGAHFPPSLILANMLIVTGAGFTTTSALMSWLIYCLVTYEGTQDRLYAELVEYGIVGPTGERNET
AWTPDLAHSLPYMDRFVKETQRLHNASFQPGRTTKTDVILPGGYLLPPNSVIVPALYAIHTNPKVWRDPFRFDPDRWDTD
EVKSRHRCAYVPFATGPRGCIGFNFALLEVKVLLGELVSRYEFVRDGQEAIDYDPEFQLIRPLNFYVRAKRRA*
>CYP540A5 Aspergillus terreus
87% to CYP540A4 A. niger
ATEG_06722.1
MQCHFYLVGDDVSTAQSLDVDARWKFEDLQRAVGGVFHVAQPTGISFHSDSNEPLTTVAD
VLTAASAPTAPVGLRIDGNAVQSPQGPPGLPLVGSFYEIFPDHLGNHYRLFRKYGPVIKTTN
MGKTIYLTDDPAVAAVCLAESAYMTKKINSDHPLWGVKDNTAIFLGDTETENWRLAHKYLPPSMGPKAVRHYTGLMQACA
RKSLPVFDELDARDEAWNVYQYMLKLASQTVGSFSLSKDFGHFDSIDSPLHPIVTNIASLLSLNKKITARGEWYRHLPFG
DPARLRHVQHTIYSLLQEQIDAVAAESRSADAPMADAALSATCAVDYLLHAVDDKGERFPPGLILANVLVVTGAGFTTTS
ALLSWLIYCLVTYEGTQDRLYQELVEYGIVGPNGERNQTTWTPDLAHSLPYMDKFVKETQRLHNASFQPGRTSKTDVVLP
GGYRLPPDSVIVPALYAIHTNPKIWRDPFRFDPDRWDTDEVKNRHRCAYVPFATGPRGCIGFNFALLEVKILLGELLSRY
EFVREGQEAIDYDPEFQLIRPLNFYVRAKRRV*
>CYP540B1 Magnaporthe grisea MG10724.4 52% to CYP540A1 AACU01001777 cont2.2064
MSSKLFYLLGNEPLTAIEIEIPSDTNDEGLQHLLASHFAIVEPKGVGYVS
GDVVLTSVPEVLAAQGPISVTIDGKPIRDVPGPTGLPYIGNYFEVYPDHL
GNNQRLFDRYGPLFKTTNMGSVVYHTNDPQLAGIFFSESDFFTKKMIPGH
PLHPIKNKEAGVFLGDTDTEEWRVAHKFLPPALGPAAVRHYAPTMQSTVE
DAFKVFDQLDERGEAWNAYWAMLKLGSQAVGKLVLGMDFKHFEKVDSPPH
EMVIRIAQSLELNKKVTSMGSWYAKMPFGAPQQLRNARERIEQMMIESVE
NASKGDEDLELQQAALTANNMVDYVLRAKDSKGNKLPRDRILEPLVVATG
AGFTTTSSLLSWLLYGLVTYPGVQDRLLQELVDNGFDHETKMTADFTQKL
TFLDYYIKETQRMHNPSYQPARTAKADMILPGGYRLPKDAIVIPALHSLH
KNPLYWDNPQRFDPDRWGTEAVKNRPAGSYAPFGMGQRMCIGFNFALQEV
KVFLPKLLYRYEFESATEGNVEYDPMFQLIRPTNLYLRARRRVKWPPRSE
EATAAAC*
>CYP540B2 Fusarium graminearum FG02138.1
AACM01000111 FGcontig1.111_scaffold1
MSTKRFHLLGEDPSTAQQIELPPSLDEQGLQHLVASHFAIVDPSVTNFSG
IGFVTDSEALPTVADVLAADDISITIDGKAVREVPGPSGLPFVGNYFEVY
PDHLGNHQRLFEKYGPLFKTTNMGNTIYQTNDPKLATIVFGESDFFSKRI
IEGHPLFPIKNKEAGVFVGDTDTEEWKEVHKFLPPALGPKAVRHYAPTMQ
RTVEDAFKVFDELDERDEAWNVYPYMLKLGAQAVGKLVLGMDFQHFSSPD
ARPHAMVLRIAQSLELNKKLTSMPSWYKSLPFGDPQRMREARAHMEAMMT
ESVANAAKGEGDLELQDAAVEAENMVDYVLRASDSKGNKLPRERIMEPLV
VATGAGFTTTSSLLSWLLYGLVVYPGMQERLLQELVDNGFDENTQITADL
TNKLTFLDKYIKETQRRHNPSYQPARTSAVDMILPGGYKLPKDSIVIPAL
HHIHNNTKIWDNPALFDPDRWDTDRVKNRPKDSYIPFATGPRMCVGFNFA
LQEVKVFLPKLVYRYKFNLAQDGPVEYDPMFQLIRPNNL*
>CYP540B3 rev Fusarium graminearum
FG03548.1 AACM01000159 FGcontig1.159_scaffold2
MSTKQFYLLGEVVSTARDIELPPAVDFEELQSIVASHFAIVKPNSK (2)
VGFIHDGRKLNAVSEILE
VNESIAISVDGNAVRDVPGPAGIPYFGNYLEIYPDHLGNHQRLFEKYGPL
FTTTSMGNRLYQTNSAELSNIFLSEDHYFTKDIVPGHPLHPIKNQEAGVF
LADTNTEQWRLAHKFLPPALGPKAVRHYAPTMQRTVESSFKVFDELDQKG
EAWNVYQYMLKLGSQAVGKLVLGMDFAHFEQVDSPLHEMVLKIAENLELN
KRVSSMGAWYAQMPFGDPKKVRQTMARIMEMMDESIARASKGQEDLELQD
AALKADNVVDYFLRATDNKGNKLPPSQFAPALLVATAAGFTTTSSLLSWL
IYSLVKYHGNQERLLQELIDNDWDENTQVTADTTSKLTFLDKFIKETQRL
HNPSFQPGRTAKVDMILPGGYRLPKGAVVISALHHMHNNKDVWENPGRFD
PDRWDTEQVKNRPPGSYIPFATGPRMCVGFNFALQEIKVFLPKLVYRYKF
SLAQDGPIEYDPYFQLIRPNNLYVQAEKRVKWPPKSE*
>CYP540B4 Aspergillus nidulans AN3861.1 67%
to 540B2 505 clan
revised 7/18/07
MLNQQFYLHGETASSAKSITLDETANLDQVKHIVAAHFAIVEPNGIGFQT
ENDCLVDVSSILTAPGPIAITIDGRAVREPEGPKGLPFVGNYFEVFPDHL
GNHQRLFDTYGPIIKTNNLGRTTYQTNDPQLSAIVLAESDFFTKKINEAH
PLYPLKTPEAGVFLGDTDTKEWRDAHKFLPPALGPKAVRHYAPTMDSCVK
DAFKVFDALDETGEAWNVYQYMLKLGSQAVGKLTLGLDFEHFTSPDAPTH
EMVHAIAELLSLNKEVTSRGDWYAKLPFGAPKRLRNLKARIEEMVDESVQ
RAARGGVSDLPLQEAALQASNMVDYAIRATDNKGEKLPKSSLIWALVVAT
GAGFTTTSSLLSWLIYGLVTYPGMQDRLLQELVDHGITEDTELTADLTEN
LPFLDKYIKEMQRRHNPSYQPGRTAKVDLVLPGGYKIPKDSVVIAALHHI
HNNPSIWDNPSRFDPDRWDTDEVKQRHKASYIPFAIGPRMCIGFNFALSE
IKVFLPRLVYRYNFIREGDGPIEYDPMFQLIRPNNL
YVRAERRVKWPAKTKSSE
>CYP540B5 Nectria haematococca
fgenesh1_pg.scaffold_13000341
Necha1/scaffold_13:983726-985420
missing 5 aa between DPN and GIG compared to
540B2
540B2 may be too long here
87% to 540B2
This gene model seems correct
MATKRFYLCGDSSTAQDIELPSSLDEQSLQHLVASHFAIVDPN (1)
GIGFINQSEALTTVADVLAAEDVAITI
DGKAVREVPGPKGLPFVGNYFEVYPDHLGNHQRLFEKYGPLFKTTNMGSTIYHTNDPALANIVFGETDFF
SKRIIEGHPLFPIKNTEAGVFLGDTDTPEWKEVHKFLPPALGPKAVRHYAPTMQKTVEDAFKVFDELDER
DEAWNVYPYMLKLGSQAVGKLVLGMDFKHFTAVDARPHEMVLRIAQSLELNKKITSMGSWYRNMPFGDPQ
RLREARARMETMMEESVANASKGVGDLDLQDAALQAENMVDYVLRASDSKGNKLPRNRIMEPLVVATGAG
FTTTSSLLSWLLYGLVVYPGMQERLLQELVDNGFDDDTQITADVTNKLSFLDKYIKETQRRHNPSYQPAR
TAAVDLILPGGYRIPKDAIVIPALHHIHNNTKIWDNPALFDPDRWDTERVKNRPNASYIPFATGPRMCVG
FNFALQEVKVFLPKLVYRYKFSLAQDGPVEYDPMFQLIRPNNLYVRAERRVKWPAKSESL*
>CYP540B6 Nectria haematococca
fgenesh1_pg.scaffold_23000209
Necha1/scaffold_23:527402-529200
60%
to 540B2 some revision at N-term, add cyan and delete some
MPLQSFYLLGEDPETAREIDVDQNASFNHLQQLIASHYAIVVPT (1)
GIGFQGTDNALSTASQVMSTKDKVAITIDGRAVRDIPGPPGLPYVGNF
FEVFPDHLGNHQRLFERYGPVIKTTNLGRTVYHSNDPEVAAVAFAESEFFTKRINDAHPLNGIKTPEAGI
FLGDTDTPEWRVTHKFLPPALGPKAVRHYAPTMQKTVEKAYEVFDLLDEREEAWNVYQYMLKLGAQAVAK
LTLGLDLEHFSSVDAPVHEIVHLIADMLSLNKKVTSRGNWYASLPFGDPKALRDKKATLERMVEERIQQA
KAGGIEDLPLQDAALRATDMI (1)
DYALRATDNKGERLPKSSLTWALVVATGAGFTTTSSLLSWLIYGLVTYP
DVQDKLLQELIDHGFTDDMEVTSDFTDRLVYLDYYIKETQRRHNPSFQPGRTSKVDLILPGGYKLPKDSV
MIPALHHIHNNPEFWDNPAKFNPDRWGTDEVKNRHKAAYLPFGTGSRMCIGFNFALQEIKIFLPKLIYRY
RFRKDGSDVTEYDPMFQLIRPNNLYVRAEKRTKLPPKSDTAVSST*
>CYP540B7 Aspergillus fumigatus Af293
GenEMBL
XP_753637.1 also EAL91599.1
76% to 540B4
MASQQFYLLGESISSARTISLDGINDLEGLRNLIASHFAIVEPSGIEFSRQDVSLTDLHEITSATTPVAI
TIDGHAVRNAPSPKGLPFFGNFFQIFPDHLGNHQRLFEQYGPLIKTNTLGRTVYQTNDPILSAIVFNESD
FFTKKINEAHPLYSLKTPAAGVFLGDTDTPEWRVAHKFLPPALGPKAVRHYAPTMQKTVEDACTIFDQLD
AQGEAWNVYQYMLKLGSQAVGKLTLGLDFEHFSSADAPIHEMVHLIAEVLSLNKKVTSKGDWYASLPFGD
PKRLRDTKARIEQLVEESVQKAQRGGVEDLPLQDAALRAANMVDYALRATDNKGEKLPKSSLVWALVVAT
GAGFTTTSSLLSWLIYGLVTYPGMQDRLLQELVDHGFDDTTEITADFTDQLTFLDKYIKETQRRHNPSFQ
PGRTAKLDLILPGGYKIPQDAVVIPALHHIHNNPAIWDNPARFNPDRWDTDEVKQRHKAAYIPFGTGPRM
CIGFNFALQEIKVFLPKLIYRYKFTREGDGPIEYDPMFQLIRPNNLYVRAERRVKWPYKSDA
>CYP540B7 Neosartorya fischeri
96% to CYP540B7 Aspergillus fumigatus = ortholog
NFIA_077230
MASQQFYLLGESISSARTISLDGMNDLEGLRNLIASHFAIVEPSGIEFSGQDISLTDLNEITSSTTPVAITIDGHAIRDA
PSPNGLPFFGNFFQIFPDHLGNHQRLFEQYGPLIKTNTLGRTVYQTNDPVLSAIVLNESDFFTKKINEAHPLYSLKTPSA
GVFLGDTDTPEWRVAHKFLPPALGPKAVRHYAPTMQKTVEDACTIFDQLDAQGEAWNVYQYMLKLGSQAVGKLTLGLDFE
HFSSADAPIHEMVHLIAEVLSLNKKVTSKGDWYASLPFGDPKRLKDTKARIEQLVEESVQKAQRGGVEDLPLQDAALQAA
NMVDYAIRATDNKGEKLPKSSLVWALVVATGAGFTTTSSLLSWLIYGLVTYPGMQDRLLQELVDHGFDDNTEITADFTDK
LTFLDKYIKETQRRHNPSFQPGRTAKLDLILPGGYKIPQDAVVIPALHHIHNNPAIWDNPARFNPDRWDTDEVKQRHKAA
YIPFAMGPRMCIGFNFALQEIKVFLPKLIYRYKFTREGDGPIEYDPMFQLIRPNNLYVRAERRVKWPYKSEA*
>CYP540B8 Aspergillus fumigatus Af293
GenEMBL
XP_748718.1 also EAL86680.1
75% to
540B7, 73% to 540B4
MSTTTTKLFHLLGEPLSTAKEIQFESTTTYGDLRHLVAAHFAIVEPSGIGFISQDSILHDVPEIAASDEI
ISITIDGKAVREIPGPKGLPVIGNFFEVYPDHLGNHQRLFEQYGPIFKTTNMGRTVYHTNDPQLSSIIFA
ETDFFTKKINAAHPLHPIKNQEAGVFLGDTDTPEWRTAHKFLPPALGPKAVRHYAPMMQETVEDAFTVFD
ALDERGEAWNVYQYMLKLGSQAVGKLVLGIDFKHFSSIDEPPHELVYRIAESLELNKKVTAWGDWYAKLP
FGDPQRLRNARGRIIEMVNESIQNAARGGIEDLPLQDAALKASNMVDYALRATDNKGEKLPKTSLMQALV
VATGAGFTTTSSLLSWLIYGLVTYPGVQERLLQELIDNGIDADTQLTADLTDRLTFLDKFIKETQRRHNP
SYQPGRTAKVDMILPGGYKLPQDSVVIGALHHLHNNPDVWSNPARFDPDRWDTEEVKNRHKTAYIPFATG
PRMCIGFNFALQEVKVFLPKLVYRYKFTRENDGHIEYDPMFQLIRPTNLYVRAERRVKWPPRSDNAVPSP
SL
>CYP540B8 Neosartorya fischeri NRRL 181
DS027697 join(1677302..1677440,1677496..1678332,1678385..1679094)
73% to
CYP540B4, 96% to CYP540B8 Aspergillus fumigatus = ortholog
name
revised from CYP540B11
NFIA_006270
MSTTTKLFHLLGEPISTAKEIQFESMTTYEDLRHLIAAHFAIVE
PNGIGFLSQDSILHDVPEIAASDDIISITIDGKAVREIPGPKGLPFIGNFFEVYPDHL
GNHQRLFEQYGPIFKTTNMGRTVYHTNDPQLSSIIFAETDFFTKKINAAHPLHPIKNQ
EAGVFLGDTDTPEWRTAHKFLPPALGPKAVRHYAPMMQETVEDAFNVFDALDEKEEAW
NVYQYMLKLGSQAVGKLVLGIDFKHFSSIDAPPHELVYRIAESLELNKKVTAWGDWYA
KLPFGDPQRLRNARGRIIDMVNESIQNAARGGIEDLPLQDAALKASNMVDYALRATDN
KGEKLPKTSLMQALVVATGAGFTTTSSLLSWLIYGLVTYPGVQERLLQELIDNGIDAD
TQLTADLTDRLTFMDKFIKETQRRHNPSYQPGRTAKVDMILPGGYKLPQDSVVIGALH
HLHNNPDVWSNPARFDPDRWDTEEVKNRHKTAYIPFATGPRMCIGFNFALQEVKVFLP
KLVYRYKFTRENDGHIEYDPMFQLIRPTNLYVRAERRVKWPPRSDKAAPSPSL
>CYP540B9 Aspergillus oryzae
BAE62604.1
80% TO
540B10, 69% to 540B1
revised
3/20/2009
MPIRLFYLSGEPSSTAREIELESTLDYDGLRHLIAA
HFAIVEPN (1)
GIGFQSQDAILSDVAEVLANE
DSISITIDGKSVREISGPKGLPIVGNFFEIYPDHLGNHQRLFEQYGPIIKTTNMGRTVYQTNDPQL
SSIIFSETDFFTKKINEAHPLHAIKNQQAGVFLGDTDTPEWRAAHKFLPPALGPKAVRHYAPTMQQTVED
AFKVFDHFDENGEAWNVYQYMLKLGSQAVGKLVLGIDFNHFSSPDAPPHELIQIIAESLSLNKKVTARGD
WYAKLPFGDPQRLRNMRYRIFDIVDQSIQNASRNGVEDLPLQDAALKASNMIDYAVRATDNKGEKLPKTS
LIQSLVVATGAGFTTTSSLLSWLIYSLVTYPGVQDRLLQELIDNDITEDTQITADLTDRLTFMDKLIKET
QRRHNPSYQPARTAKVDMILPGGYKLPEESVVVGALHHLHNNPEVWSNPTRFDPDRWDTEEVKNRHKAAY
IPFATGPRMCIGFNFALQEVKVFLPKLVYRYKFTKENDGPIEYDPMFQLIRPNNLYVRAERRVKWPPKSE
SATTRASL
>CYP540B9 Aspergillus flavus
99% to CYP540B9 Aspergillus oryzae
AFL2G_07990
MPIRLFYLSGEPSSTAREIELESTLDYDGLRHLIAAHFAIVEPNGIGFQSQDAILSDVAEVLANE
DSISITIDGKSVREI
PGPKGLPIVGNFFEIYPDHLGNHQRLFEQYGPIIKTTNMGRTVYQTNDPQLSSIIFSETDFFTKKINEAHPLHAIKNQQA
GVFLGDTDTPEWRAAHKFLPPALGPKAVRHYAPTMQQTVEDAFKVFDHFDENGEAWNVYQYMLKLGSQAVGKLVLGIDFN
HFSSPDAPPHELIQIIAESLSLNKKVTARGDWYAKLPFGDPQRLRNMRYRIFDIVDQSIQNASRNGVEDLPLQDAALKAS
NMIDYAVRATDNKGEKLPKTSLIQSLVVATGAGFTTTSSLLSWLIYSLVTYPGVQDRLLQELIDNDITEDTQITADLTDR
LTFMDKLIKETQRRHNPSYQPARTAKVDMILPGGYKLPEESVVVGALHHLHNNPEVWSNPTRFDPDRWDTEEVKNRHKAA
YIPFATGPRMCIGFNFALQEVKVFLPKLVYRYKFTKENDGPIEYDPMFQLIRPNNLLSGSTGPWAYKA*
>CYP540B10 Aspergillus oryzae
BAE59862.1
80% TO
540B9
revised
3/18/2009
MPIRQFYLLGEPVSSAREIEIESSLDIAGLQHLIAAHFAIVEPS (1)
GIGFQANDNTLNDIPEITSSNGPVAITIDGKE
VREPPGPKGLPIVGNFFEVYPDHLGNHQRLFEQYGPIIKTTSLGR
TTYQTNDPVLSSIVFAESDFFTKKINEAHPLYALKQPSAGVFLGDTETPEWKVAHKFLPPALGPKAVRHY
APTMQETVEDAFKVFDEFDKQGEAWNVYQYMLKLGSQAVGKLTLGLDFQHFTSPDANLHEMVNLIAELLS
LNKKVTSKGDWYAKLPFGDPQKLKQIKVRIIEMVEESIRSAERGGVVDLPLQDAALQASNMVDYAVRATD
NKGEKLPKTSLVWALTVATGAGFTTTSSLLSWLIYGLVTYPDMQERLLQELIDHDIDENTQLTADITDRL
TFLDKYIKETQRRHNPSFQPGRTAKVDLILPGGYKIPQDSVIIPALHHIHNNPELWDNPQKFNPDRWDTE
EVKNRHKAAYIPFAMGPRMCIGFNFALQEIKVFLPKLIYRYKFTREGDGHIEYDPMFQLIRPNNLYVRAE
RRVKWPPKTEN*
>CYP540B10 Aspergillus flavus
100% to CYP540B10 Aspergillus oryzae
80% to CYP540B7
AFL2G_06859
MPIRQFYLLGEPVSSAREIEIESSLDIAGLQHLIAAHFAIVEPSGIGFQANDNTLNDIPEITSSNGPVAITIDGKE
VREPPGPKGLPIVGNFFEVYPDHLGNHQRLFEQYGPIIKTTSLGRTTYQTNDPVLSSIVFAESDFFTKKINEAHPLYALKQPSA
GVFLGDTETPEWKVAHKFLPPALGPKAVRHYAPTMQETVEDAFKVFDEFDKQGEAWNVYQYMLKLGSQAVGKLTLGLDFQ
HFTSPDANLHEMVNLIAELLSLNKKVTSKGDWYAKLPFGDPQKLKQIKVRIIEMVEESIRSAERGGVVDLPLQDAALQAS
NMVDYAVRATDNKGEKLPKTSLVWALTVATGAGFTTTSSLLSWLIYGLVTYPDMQERLLQELIDHDIDENTQLTADITDR
LTFLDKYIKETQRRHNPSFQPGRTAKVDLILPGGYKIPQDSVIIPALHHIHNNPELWDNPQKFNPDRWDTEEVKNRHKAA
YIPFAMGPRMCIGFNFALQEIKVFLPKLIYRYKFTREGDGHIEYDPMFQLIRPNNLYVRAERR
VKWPPKTEN*
>CYP540B11 Neosartorya fischeri NRRL 181
DS027697 join(1677302..1677440,1677496..1678332,1678385..1679094)
73% to
CYP540B4
MSTTTKLFHLLGEPISTAKEIQFESMTTYEDLRHLIAAHFAIVE
PNGIGFLSQDSILHDVPEIAASDDIISITIDGKAVREIPGPKGLPFIGNFFEVYPDHL
GNHQRLFEQYGPIFKTTNMGRTVYHTNDPQLSSIIFAETDFFTKKINAAHPLHPIKNQ
EAGVFLGDTDTPEWRTAHKFLPPALGPKAVRHYAPMMQETVEDAFNVFDALDEKEEAW
NVYQYMLKLGSQAVGKLVLGIDFKHFSSIDAPPHELVYRIAESLELNKKVTAWGDWYA
KLPFGDPQRLRNARGRIIDMVNESIQNAARGGIEDLPLQDAALKASNMVDYALRATDN
KGEKLPKTSLMQALVVATGAGFTTTSSLLSWLIYGLVTYPGVQERLLQELIDNGIDAD
TQLTADLTDRLTFMDKFIKETQRRHNPSYQPGRTAKVDMILPGGYKLPQDSVVIGALH
HLHNNPDVWSNPARFDPDRWDTEEVKNRHKTAYIPFATGPRMCIGFNFALQEVKVFLP
KLVYRYKFTRENDGHIEYDPMFQLIRPTNLYVRAERRVKWPPRSDKAAPSPSL
>CYP540B12 Aspergillus niger
fgenesh1_pg.C_scaffold_3000327|Aspni1
76% to CYP540B7
MPSQTFYLLGESPSSAKEIQIDPSATIDDLKHLIAAHFAIVEPSGIGFQGYDAALSELSEVLAAPGPLPLTIDGHAVREP
PCPRELPFVGTFFEVYPDHLGNHQRLFERYGPIVKTNNLGRVTYQTNDPKIAAIAFAESDFFTKKINEAHPLAGLKTPSA
GIFLGDTDTEEWRVAHKFLPPALGPKAVRHYAPTMQKTVEDSFKVFDALDEQGEAWNVYQYMLKLGSQAVGKLVLGLDFK
HFEAPDAPVHEMVHNIAEMLSLNKKVTSMGNWYAGLPFGDPKRLRSLRTSIENMVAESMEAASRGGHEDLPLQDAALKAD
NMVDYAIRATDNKGQKLPQSSLTWALVVATGAGFTTTSSLLSWLIYGLCVYPGMQERLLQELVDHGFDENTEITADFTDK
LEFLDKYIKETQRRHNPSFQPGRTAKVDLVLPGGYKLPKESVIVPALHHIHNHPDLWDNPARFNPDRWDTEEVKSRHKAA
YIPFAMGPRMCIGFNFALQEVKVFLPKLVYRYKFSMEDNGPIEYDPMFQLIRPNNLYVRAERRVRWPPKSRATAA*
>CYP540B13 Aspergillus niger
fgenesh1_pm.C_scaffold_1000635|Aspni1
81% to CYP540B11
MSAKLFHLLGEPVANAREIEVDSSLDYDGLRNLIAAHFAIVDPNGIGFQSEDAVFTSVAEIIASETPISIAIDGKPVREV
PGPKGLPIIGNFFEIYPDHLGNHQRLFEQYGPLFMTTNYGRTVYHTNDPELSAIVFSESDFFTKKINESHPLHAIKNKEA
GVFLGDTDTPEWRTAHKFLPPAFGPKAVRHYAPVMQQTVEDAFKVFDAFDEQGEAWNVYQYMLKLGSQAVGKLVLGIDFQ
HFANMNAPPHELILLIAESLELNKKITARGDWYAKLPFGDPKRLQQIRGRVWNIVDESIQNASRGGVEDLPLQDAALKAH
NMIDYAIRATDNKGEKLPKTSLIQALVVATGAGFTTTSSLLSWLIYSLVNYPGVQDRLLQELVDNGIDADTQITADLTDR
LTFMDKFIKETQRRHNPSYQPARTAKVDMILPGGYKLPEDSVVIGALHHLHNNPEVWDNPTRFNPDRWDTEEVKNRHKSS
YIPFAAGPRMCIGFNFALQEVKVFLPKLVYRYRFTKETDGPIEYDPMFQLIRPNNLYVRAERRVKWPPKTESPLPTASL*
>CYP540B14 Mgf Mycosphaerella
graminicola
56% to 540B11, 57% to 540B4
MATTKSFYFQGSKDKNLSLDVDVENINDLAGLKEVIGTSCAVVKPEGLSFYLEDELLEEISDIKEAQGRISIKVDGHTVR
SVPGPPGLPLIGNYFEVFPDHLGNNQRLFDKYGPIFSTNNMGSVVCQTNDPELADVCFAETEFFSKEINSSHPLYPIKQQ
QAGVFLADTSAPAWKVVHKFLPPALGPKAVRHYAPEMNGCCNEAFPVFDKLESENEAWNVYQFMLKLSSGAIGKIMLGQD
FEHFSSVDAPLHKMVLAMAEVLSINKKIASRGEWYSHLPFGDPARLKNLQKYMAEFIETSIKNAKSNGTEDLPLQDAALK
ASNVIDYLVRATDSTGKQLPKENLMPAVTVACGAGFTTTSSLLSWCIYALVTYPGIQAQLLQELVDNDINDSDNITAEQI
DELPVLANFIKEAQRRHNPSYQPGRTAQKDLILPGGYQMKKGTVVICAIHHIHNNPKNWDNPDKFDPDRWNHDPLKGKPK
SAYAPFAQGGRMCVGFNFALLEVKIFMCKLVYRYHWDKEGDMETSYDPFFQLIRPVDLYVKTTKRQTYPTKSGEGQA
>CYP540B15 Fusarium oxysporum
90% to CYP540B5
FOXG_04494 revised
MATKRFHLMGEDPSTAQEIEIPTSLDEQGLQHLVASHFAIVDPS
GIGFVTESDALTTVADVLATDDISITIDGKAVREVPGPKGLPLVGNYFEVY
PDHLGNHQRLFEKYGPLFKTTNMGSTIYHTNDPKLANIVFGETDFFSKRIIEGHPLFPIKNKEAGVFLGDTDTEEWKEVH
KFLPPALGPKAVRHYAPTMQKTVEDAFKVFDELDERDEAWNVYPYMLKLGSQAVGKLVLGMDFQHFTSPDARPHAMVMRI
AQSLELNKKITSMGSWYKNLPFGDPQRLRDARAHMELMMKESVENASKGEGDLELQDAAVQAENMVDYVLRASDSKGNKL
PRERIMEPLVVATGAGFTTTSSLLSWLLYGLVAYPGMQERLLQEMVDNGFDENTQITADLTNKLTFLDKYIKETQRRHNP
SYQPARTASVDMVLPGGYKLPKDSIVIPALHHIHNNTKIWDNPALFDPDRWDTDRVKNRPNASYIPFATGPRMCVGFNFA
LQEVKVFLPKLVYRYKFSLAQDGPVEYDPMFQLIRPNNLYVRAERRIKWPSKSD*
>CYP540B15 Fusarium verticillioides
99% to CYP540B15 Fusarium oxysporum = ortholog, only 3 aa
diffs
FVEG_07621 revised
MATKRFHLMGEDPSTAQEIEIPTSLDEQGLQHLVASHFAIVDPS
GIGFVTESDALTTVADVLAADDISITIDGKAVREVPGPKGLPLVGNYFEV
YPDHLGNHQRLFEKYGPLFKTTNMGSTIYHTNDPKLANIVF
GETDFFSKRIIEGHPLFPIKNKEAGVFLGDTDTEEWKEVHKFLPPAL
GPKAVRHYAPTMQKTVEDAFKVFDELDERDEAWNVYPYMLKLGSQAVGKLVLG
MDFQHFTSPDARPHAMVMRIAQSLELNKKITSMGSWYKNLPFGDPQRLRDAR
AHMELMMKESVENASKGEGDLELQDAAVQAENMVDYVLRASDSKGNKL
SRERIMEPLVVATGAGFTTTSSLLSWLLYGLVAYPGMQERLLQEMVDNGF
DENTQITADLTNKLTFLDKYIKETQRRHNPSYQPARTASVDMILPGGYKL
PKDSIVIPALHHIHNNTKIWDNPALFDPDRWDTDRVKNRPNASYIPFATG
PRMCVGFNFALQEVKVFLPKLVYRYKFSLAQDGPVEYDPMFQLIRPNNLY
VRAERRIKWPSKSD*
>CYP540B16 Fusarium oxysporum
92% to CYP540B3
FOXG_16987
MATKQFYLLGEAPSTTREVDLPPAVDFEELQNIVASHFAIVKPNGVGFVHDDRRLNVVSEVLDKDEPIAVSINGNAVRDV
PGPAGIPYFGNYLEIYPDHLGNHQRLFEKYGPLFVTNSMGNRLYQTNSAELSNIFLAEDHYFTKDIVPGHPLHPIKNQEA
GVFLADTDTEQWRLAHKFLPPALGPKAVRHYAPTMQRTVEQSFKVFDELDEKGEAWNVYQYMLKLGSQAVGKLVLGMDFA
HFEEVDSPLHEMVLKIAENLELNKRVSSMGAWYAKMPFGDPKKVRDTMGRIMEMMTESIARASKGQEDLELQDAALKAEN
VVDYFLRAKDNKGSKLPPSQFAPTLLVATAAGFTTTSSLLSWLIYSLVKYPGNQERLLQELIDNDWDEDTQVTAETTSKL
SFLDKFIKETQRLHNPSFQPGRTAKVDMILPGGYRLPKGAVVISALHHMHNNKDIWENPGRFDPDRWDTEQVKNRPPGSY
IPFATGPRMCVGFNFALQEIKVFLPKLVYRYKFSLAQDGPIEYDPYFQLIRPNNLYVQAEKRVKWPPKSE*
>CYP540B16 Fusarium verticillioides
96% to CYP540B16
FVEG_13789
MSTKHFYLLGEAPSTAREIELPPAVDFEELQNIVASHFAIVKPNGVGFVHD
DKRLNAVSEVLDKDELIAVSVNGNAVRDVPGPAGIPYFGNYLEIYPDHL
GNHQRLFEKYGPLFVTNSMGNRLYQTNSAELSNIFLAEDHYFTKDIVPGHP
LHPIKNQEAGVFLADTDTEQWRLAHKFLPPALGPKAVRHYAPTMQRTVE
QSYKVFDELDEKGEAWNVYQYMLKLGSQAVGKLVLGMDFAHFEEVDAPL
HEMVLKIAENLELNKKVSSMGAWYAKMPFGDPKKVRDTTARIMEMMMESIA
RASKGKEDLELQDAALKAENVVDYFLRAKDNKGSKLPPSQFAPTLLVATAAG
FTTTSSLLSWLIYSLVKYPGNQERLLQELIDNDWDDDTQVTAETTNKL
SFLDKFIKETQRLHNPSFQPARTAKVDMILPGGYRLPKGAVVISALHHMH
NNKDVWENPGRFDPDRWDTEQVKNRPPGSYIPFATGPRMCVGFNFALQEI
KVFLPKLVYRYKFSLAQDGPIEYDPYFQLIRPNNLYIQAEKRVKWPPKSE*
>CYP540B17 Aspergillus clavatus
85% to CYP540B7
ACLA_013210
MPTQQFYLSGEPISSARTIELDGMQSLDDLRNLIAAHFAIVEPSGIDFQGRDTCLTDIPEITSSASPVAITVDGHAVRDV
PSPAPLPLVGNFFQVFPDHLGNHQRLFEQFGPLIKTTTLGRTVYQTNDPAISAIVLNESDFFTKKINEAHPLYSLRTPVA
GIFLGDTDTPEWRVAHKFIPPALGPKAVRHYAPTMQKTVEDACQVFDELDERGEAWNVYQFMLKLGSQAVGKLTLGLDFQ
HFTDVDAPIHEMVHAIAEVLSLNKKVTSKGDWYANLPFGDPKRLKMLKARIEQMVEESIENAGRGGVEDLPLQDAALRAS
NMVDYAIRATDNKGEKLPKSSLIWALVVAAAAGFTTTSSLLSWLIYGLVTYPGMQDRLLQELIDHGFTDDTEITADFTDQ
LPFLDKYIKETQRRHNPSFQPGRTAKVDLVLPGGYRIPKDAVVIPALHHIHNNPAVWDNPARFDPDRWDTDEVKKRHKAA
YIPFPTGPRMCIGFNFALQEVKVFLPKLIYKYKFSREGDGPIEYDPMFQLIRPNNLYVRAEKRVKWPPKSE*
>CYP540B18 Trichoderma atroviride
GE290941.1
77% to CYP540B10
MAIQQFYLLGESETATTAIDIDSNLDFDGLRHLVASYFAIVEPNGVGFQFQENALQEVSDVSSAAGPVA
ISIDGHAVREVPGPKG
LPYLGNFLEIYPDHLGNHQRLFEHYGPIIKTVNMGRAVYQTNDPKIATIAFAESDFFTK &
KINEDHPLYALKTPAAGVFLG &
DTETEEWKIAHKFLPP
>CYP540B19 Aspergillus terreus
83% to CYP540B12
ATEG_10264.1
MPSQTFYLLGQSLSSAKEVGIETSQTFESLQFLIAAHFAIVDPSGITFQGPDAVLTEVAEVLAATAPVPITIDGHPVRDP
PCPKELPFVGTFFEVYPDHLGNHQRLFERYGPVIKTSNLGRVTYQTNDPKIAAIAFAESDFFTKKINESHPLHALKTPAA
GVFLGDTDTPEWRVAHKFLPPALGPKAVRHYAPTMQQTVEDAFKVFDKLDEQSEAWNVYQYMLKLGSQAVGKLTLGMDFQ
HFDAPDTPVHEMVHNIAEVLSLNKKVTSKGDWYSALPFGDPRRLKNLRVRIEEMVGESMKKATRAGIEDLPLQDAALTAS
NMVDYAVRATDNKGEKLPKSSVVWALIVATGAGFTTTSSLLSWLIYGLCEYKGMQERLLQELIDHGFDENTKMTADFTEK
LEFLDKYIKETQRRHNPSFQPGRTAKVDLILPGGYKLPKDAVIIPALHHIHNNPDLWDNPARFNPDRWDTEEVKSRHKAA
YIPFAMGPRMCIGFNFALQEIKVFLPKLIYRYKFSREGDGPIEYDPMFQLIRPNNLYVRAERRTKWPVKSRSASP*
>CYP540C1 Magnaporthe grisea MG11098.4 46% to CYP540A1 missing N-term
AACU01001916.1 cont2.2255 runs off end
2 IHRVPGLDAFPIVGNRLELYPDILGNVERLCARYGGIIKTIN
MGSVTYYTNDPSIARHVLRESEFFTKKTSDPAHPLHFMADQEALFTCDSD
SPAFGPSHRFIPPCMAPKAIRHYTPSVQQCVQKVLPVLDAISDSSLAFNV
YQYMFKLAGQVIWKIVFGADLGHFDSLDAKPFETIRDLGQYVALMKRVSL
RGQWYGYLPFGDPRRMREARDRVWKGIGEAIEQAARTGTDNRDLPLQEAA
LHAACLADYLQRAVDNEGNKLPREYLVSNCVILFGAG
FLTSSSLLAWCIFALCRYEG
VQDRLLQELVDHGARPDVVWTMDQLNAMPYLDQFVKETQRMHN
PSFQTARNARRDVVLPGGKAIPAGSVVIPMFPALHKNPAHWDNPARFDPE
RWGTPAVKKLPRAAYTPFAAGSRGCIGFSLALLEVKMAMAILVYRYKFSD
ASLEPVVYDPEFLVVRPLNFYAKAAIRTVLPVARGEGAGAY*
>CYP540C2 Magnaporthe grisea MG09598.4 poor match 62% to part of MG11098.4
AACU01001656.1 cont2.1833
14398
MFISNYIVDETVNRSLLKHGSRVITVGTGSVTSERSLNTCLLSSQRPRYI
SLENITDLEALKSRVGEEFGVVQPS
14093 EITFHAGDGTQLHCLGDVSRCRSTI
DIRIAKIPIHSPLACSRDELYPNLFGNVDRLCARYGAKVIKTDN
MGMVAY
YSNDPVIARHVLQEGGFFSKRTPDPGDPLHFVSDSEALLGDGDSPAFGPS
HHFIPPCVAPKAVRYYTPSVQRSVEKAFYILDAMSDGSLAFNVYQYMFKL
AGQIVWKTVFGADLGHFNSIEAKSYKTIHHLSEYLALKQRLSLRPPWYAN
LPFGDPRRMREVRHLLWAGVDEAIEQCCTDACTDEKESQLYKGALHTNCL
AADLQKAVDGKGNRLPREHLVNSCLVLFGAGFVTLSTLLSWCIYALCRYNS
VQDRLLKELLDHGVAEDKA
WTMDELNDMPYLDWFVKETQRIYSPSLQTARVAQRDVVLPGGVMISEGSV
VIPTLSHQDSVSRDSPVRFDPESWETKAARTLPQXXXXXXXXXSRGCAGFSRTLLEVKM
AMALLVYRYEFSHATVEPVVYDAELLAVRPVNLYARTKRRTCWPGPSPKK
EDSF*
>CYP540D1 Aspergillus nidulans AN9218.1 46%
to 540B3 505 clan
MTVQTFYLIGEKERSTRELDVGDPKTVNALRQGLAEVFNILSAEGIDFHD
CHGPISTIESILRSESVGITVNGHPVRYPQQPQGIPIFGNHFEIYPDHLG
NHERLFNKYGSVIRTNNMGRVTYLTNDPDIAALAFRDNDYFTKAPSSASH
PLYGIRDQTALFLCDTESPAWKEAHKFIPPSMTPRAVRHYTPLLQQSVDT
VFNVLDKFDNNGQAFNVYHLTAKLASQVICQLVLGVDLHHFDAVDSPVHP
IIVLLQRYLTLNRRVQTKGAWYSYLPF GDPVALKNTRRELYGLIEEAVIT
CQKKNGGTTGDLPIQT
AALHATCLVDYLARATDEHGNKLRHEYILSNTLA
LVGAGFVTSSAFLSWLIYSLVEYPGQQDRLLQELVDHGAVSDKRWTYDEI
QALPFLDAFVKEAQRMHSPSFQPARNVKKDIILPGGWALPQGSILIPSIP
HLHHHTAYWENPDRFDPDRWRTEKVKNRHRSVYVPFAAGPRSCIGFNVAL
QEVKISLAELVYRYEFVNATNEGIEYDPDFIVIRPVNFYVRAIRRTEWPA
RSP*
>CYP540E1 Aspergillus clavatus
41% to CYP540D1, 42% to CYP540A3, one
frameshift
potential pseudogene
AAKD03000007.1
ACLA_003960
MATKSLYLEGRPPEETLCSVDISGLKTLDDLKYRTASIFGVALPKSISFHNESGLLSSMDDISTTVTKIGVHVDDSVIRV
PHGPRELPFVGQYFEIHPDHLGNHERLFQKYGNVIKTVVMGRTVYLTNDPRVTEVVFGENEFFTKKTSDFNHPFFWVNDN
MALLVGDTGAPAVKLAHKFIPPSMSTAAAQHYMPILQHAIQDSFAVFDQLDDRQAAWNTFQFMFKLSGQMIGKVALGMDL
DHFQTVDTQPHQIMHLLGESIRLTRQASLSHPYLVYLPFSA
VRCLRNTKKT &
LVSALYQTVSPSLISEAPDLPMAQ
AAIQSTCIADYLKRAVDEDNQKMPKEYILPNLVSILAAG
LSTTSSVGSYLLYLLAHHQDMQSRILQELINNNVTPTASWDYKTLMSLPFLDSFVKETLRLHNPAFQPARYAKKDVIVPG
AYHLPAGAVVNPVFFSLHRNKDYWENAHRFDPDRWLAADVQKHRTAYTPFAVGPRRCVGFNLANLQLRLMLAMLIFRYKF
VDVSPEPVVNDHEYLLDRLVNCYVRAVRRTSWPEKEL*
>CYP541A1 N.
crassa AABX01000779.1 cont3.283 NCU05006.1 (version3)
7113
MSTPIPRPPGIPVLGNVFDITPSNTWWSLKALAEKY (1) 7220
7273
GEIFQVKILGKTIV
FVASAALAEEICDEQRFQKYVGGPIVEIRATVHDSLFTAFHHEQSWGIHH
RIIAPLLTPQAVSGYTDDINLCATEVIQKWASLGDSNVLEPLVDLNLLNL
EATSLTLFSQKLNCIQAGGHPVIQAMEDAVSEAIMRPTRPGLVNWLLYSS
KFKKATKTLRTWAADTVKYRQENPTDKHDMLWAFMNAKDPETGKGLSESE
ILDEIVTMPIGSATAPCAVTATIYYLLQNPEVVTKAREELDRVIGTGPLK
DEHLSQLHYIEGITRETLRLSCAAPGFNIEPIPRQNKADKSPLLLQGGKY
QVAHDQKLIIVLAGVNRDPAVFEDSLAFKPERMMGEEFDRLPKGVKKWYG
NGKRECIGKEWANNFLKIVTARLIHEIDFEVADEGYEFRQDGWFQIRPVA
FKVRVKPRVRA* 8550
>CYP541A2 AAIL01000415.1 Trichoderma reesei QM9414
62% to CYP541A1, no introns
66598
MTTPIPKPPGVPLLGNIFDVKPGNTWDSLRKLAEKYGEIFQIKVLGQTIVFVASAALAEE 66777
66778
LCDEKRFRKYVGGPVVEIRAAVHDSLFTAYDHEPSWGVAHRIIYPKLSPEAMKLHFGEMR 66957
66958
DLATELFNTWRGLGDKNTISPLEQLNRLNLEATTYVLYGKRLNTLIGPPHPELQAMEDST 67137
67138
SEAMKRPTRPGVLNSLLYGRKFKSSIKVMRDYAADLVKYRQENPTDRQDVLAAIMNTPDP 67317
67318
ETGKKLTDSQVIDEIVTMPIGSSTAPCLLVWAIYFLLKNPETIVKAREELDRVLGDREFE 67497
67498
LEHLEQLEYVQGIVRESLRLSSAAPGFNIEPLPKEGDKSPVLLGGGKYQVAHNQAMII 67671
67672
VLHGVNRDPAVFDDPLAFKPERMVGEAFENLPAAAKKWFGNGKRVCIGRYYALQWSLVVL 67851
67852
AKMIREFDFEMADPEYELALDGWFNIRPIDFYVKVKPRAT* 67974
>CYP541A3 AAFU01000004.1 Chaetomium globosum CBS 148.51
66% to 541A1
89914
MSTPIPQPPGVPLLGNIFDVDPSNTWWSLKTLAEKY (1)
89700
GEIFQIKVLGHRIVFVASAALAEEICDEKRFRKYVGGPIVEIRYTVHDALFTAYDHEESW 89521
89520
GIAHRIMVPQLTPDAVASHFDEVIQCTDGLIAKWSGLESGGRTRPMDDLNRLNLEANTLT 89341
89340
LFGKKLNCFEGPEHPMIKAMEDATSEAMKRPNRPKLLNWLIHDGKLKKATKVMRGFAADL 89161
89160
VKERQENPSERRDMLWTMLNVKDPETGKALTESQVIDEIVSMPIGSSTAPCAIAAAIYFL 88981
88980
LQNPDALVKARDEIDAVVGEGPFKQEHVSQLQYVAGLVRETLRLSCAAPGFNIEPIPK-- 88807
88806
KGDESPVLLAGGKYQVPHNQAMIIVLAGVNRDPAVFEEPLAFRPERMMGEAYEQLPSAVK 88627
88626
KWFGNGKRECIGKHWAWEFLVVVITKLISELDFEAADPNYQFKQDGWFNIRPIDFSVKVK 88447
88446
SRTR 88435
>CYP541B1 Aspergillus nidulans AN8004.1 49% to 541A1
505 clan
MPTPIPQPKGLPVLGNLFSLDSKNPWGSFNKLAAASPSNRPIFKISILGH
DIVFVTSAALLEEICDETRFRKCVTGPIVQIRDAVHDSLFTAYHSESEIW
GVAHRIMKPLVSPEAIEGVFNEMRETTDDLIKKWTASSKQRVNVCNDLDR
SNHEANMLAFFHQKVSIMNGTEPAVIASCQNATMEAVKRSSRPKFLTWLM
GHQKRYDSDIKIMRNYGAEIVRKRREEYPDGGPKDMLHALLHGVDSETGK
KLSESQVLDEIINIFIGSATAPNLLSFGLYYLATNPDVVTKAREELDAVV
GSGPFEHAHLSQIPYTEGILRESLRLSATAPGFNIEPIPSPGNEPVLLAG
GEYQVPRTQPLIALLTAVNRDPEVFEDPESFKPERMVGEKYDALPSGVKK
GFGNGKRQCFGTRYAWEWSLLVLARLIKEVDFELADKKYKVTNEGVNYNG
AFSTRPVGFFLLASPRASV*
>CYP541B2
XM_742988.1 Aspergillus fumigatus
67% to 541B1 49% to 541A1, 98% to CYP541B4Nf allele
MPTPIPLPSGLPILGNLLSISPGNTWGSFNKLAVNNKNFYPIFK
ITILGHDIVFITSAKLLEEICDEKRFRKCVTGPIVEIREAVHDSLFTAYHDEESWGIA
HRIMAPLMTPEAVIDAFAGMRETATDLVKKWTAGPRQRINVSNDMDRLNHAANMLCFF
DQRIHCLEGPEPSVLQAMEAATFEALRRPTRPKVLKWLIYQRRFDRYIKTMRDYAAEI
VAKRRAAPTEKKDMLHAIMHGTDPQTGKALTESQYLDEIINLFIGSATAANLVSFALY
YLMKNPHEIARAREEIDAVVGGPAAQLEHEHLARLPYCEAILRESLRLSATAPGFNIE
PIPDLEQPVLLAGGEYQVPNKQPLIALLAAVNRDPEVFEDPDAFKPERMVGEKYDRLP
SGVKKGFGNGKRECFGKRYAWEWSFMILVTIMKDVDFVLADKNYKTEVGGVNYNGAFS
TKPLGLFALTGPRQSV*
>CYP541B2 AAKE02000015.1 Neosartorya fischeri NRRL 181
67% to 541B1, 97% to CYP541B2
Aspergillus fumigatus = ortholog
NFIA_039470
347217
MPTPIPHPSGLPILGNLFSISPGNTWGSFNKLAVNNKNF (1) 347101
347032
YPIFKITILGHDIVFITSAKLLEEICDEKRFRKCVTGPIVEIREAVHDSLFTAYHDEESWGI 346847
346846
AHRIMAPLVTPEAVIDAFAGMRETATDLVKKWTAGPRQRINVSNDMDRLNHAANMLCFF 346670
346669
DQRIHCLEGPEPPVLQAMEAATFEALRRPTRPKVLKWLIYQRRFDSYIKTMRDYAAEIVA 346490
346489
KRRAAPTEKKDMLHAIMHGTDPQTGKALTESQHLDEIINIFIGSATSANLVSFALYYLMK 346310
346309
NPHEIARAREEIDAVVGGPTAQLEHEHLARLPYCEAILRESLRLSATAPGFNIEPIPDL 346133
346132
EQPVLLAGGEYQVPNKQPLIALLAAVNRDPEVFEDPDAFKPERMVGEKYDRLPAGVK 345962
345961
KGFGNGKRECFGKRYAWEWSFMILVTIMKDVDFVLADKNYKTEVGGVNYNGAFSTKPLGL 345782
345781
FALTGPRQSV* 345749
>CYP541B3
AP007162 Aspergillus oryzae
50% to 541A1, 66% to 541B1
MPSPIPKPKGVPILGNVFDLDGNNTWGSFNKLAKDYRPIFKINI
LGKDIVFITGAHLLEEVCDETRFRKCVAGPILAIRDAVNDSLFTAKHTTEEIISWGIA
HRIMAPLVSWEAVEQVFSGIQETTDDLIKKWTTGSRQRINVTNDLDRCNHAANMLCFF
DQRVHIMEGPEPAVIKAMGCATNEAMHRPFRLRIVNWLFHSRKWNAWIKTMRDYGKDI
VETRRANPTDKKDMLYALLEGKDPETGKGLTDSQVLDEIINIFIGSATAPNLIAFAMY
YLANNPDAAAKAREELDAVVGGPSVRIEHEHLARLPYTEGVLRESFRLSGVAPGFNIE
PIPENEGPVLLAGGEYEVPKGQALIAILAAVNRDPAVFEDPEAFKPERMVGENFDRLP
KGVKKGFGNGKRECIGKRYAWQWSFMVLASILKDVEFELADPNYKVGNDGVNCNGAFS
VRPQEMFVVTGPRARAA*
>CYP541B3 #
AAIH01000171.1 Aspergillus flavus NRRL3357
the ortholog of Aspergillus oryzae CYP541B3 only
2 aa diffs
AFL2G_09797
MPSPIPKPKGVPILGNVFDLDGNNTWGSFNKLAKDYRPIFKINILGKDIVFITGAHLLEEVCDETRFRKCVAGPILAIRD
AVNDSLFTAKHTPEEIISWGIAHRIMAPLVSWEAVEQVFSGIQETTDDLIKKWTTGSRQRINVTNDLDRCNHAANMLCFF
DQRVHIMEGPEPAVIKAMDCATNEAMHRPFRLRIVNWLFHSRKWNAWIKTMRDYGKDIVETRRANPTDKKDMLYALLEGK
DPETGKGLTDSQVLDEIINIFIGSATAPNLIAFAMYYLANNPDAAAKAREELDAVVGGPSVRIEHEHLARLPYTEGVLRE
SFRLSGVAPGFNIEPIPENEGPVLLAGGEYEVPKGQALIAILAAVNRDPAVFEDPEAFKPERMVGENFDRLPKGVKKGFG
NGKRECIGKRYAWQWSFMVLASILKDVEFELADPNYKVGNDGVNCNGAFSVRPQEMFVVTGPRARAA*
>CYP541B4 AAKD02000007.1 Aspergillus clavatus NRRL 1
note only 215bp from CYP661B2
66% to 541B1, 79% to CYP541B2
ACLA_002550
578942
MPTPIPQPPGLPILGNLFDLKPGNTWGSFNKLAVKY (1) 578835
578761
RPIFKISVVGHDIVFVTSAKLLEEICDEKRFRKCVTGPIVEIRQAVHDSLFTAYHNEESWG 578579
578578
IAHRIMAPLVSPDAVAEAFAGMRETTKDLIQKWTAGPRQRVNVCNDLDRLNHAANMLCFF 578399
578398
DQRIHCLEGQEPSVIKAMDAATNEAMRRAARPKLLNWLIYQRRFNAYNRTMRDYAAEIVA 578219
578218
QRRAYPTDKKDLLDALLHGKDPQTGLALTDSQHLDEIINIFIGSATSPNLVSFALYYLMK 578039
578038
HPQEITRAREEIDGVVIDQLEHRHLASLPYCEAILRESLRLCATAPGFNIEPIPGQE 577868
577867
EPVLLAGGEYQIPNKQPMIALLSAVNRDPEVFEEPDAFIPERMVGENYERLPAGVKKGFG 577688
577687
NGKRQCFGTRFAWEWCFMVLVTILREVNFDLADKQYQTAVEGINYNGAFSTKPLGLFAVT 577508
577507
GPRQRL* 577487
>CYP541B5 AAJN01000228.1 Aspergillus terreus NIH2624
63% to 541B1
ATEG_09231.1
134658
MPSPIPQPKGYPLVGNLFDIDSQNPWGSFNKLALKNKY (1)
134844
RPIFKINILGKDLVFVTGAALLEEVCDEKRFRKCVSGPIVQIRDAVHCSLFTAYEKEM 135017
135018
EDWGIAHRIMAPMVSTEAVAELYSGMKETMPDLIKKWTAGPRQRVNVTNDLDRLNHAANM 135197
135198
LCFFNQRVDCVNGPEPPAIHAHEESTVEATRRSSRMKLVNWLFHQKKYDNYIKIMRDYGA 135377
135378
DIIAHRKAYPTDKNDMLNALMNGKDPQTGKGLTESQVQDEIINCFIGSATAPNLISFALY 135557
135558
YLMKNPDTIRQAREEIDAVVGVSESVEQEHLARLPYCKAIIDETFRLSAVAPGFNLEPH 135734
135735
PDDEGPVLLAGGEYEIPRKQALIVLLSAVGRDPAVFEDPDAFKPERMLGEKFDRLPAGVK 135914
135915
KRFGNGKRECIGKRYAYEWSFMTLVSILKDVEFELADANYVMNNDGVNYNGAFSVKPQGF 136094
136095
FAVTGPRQRSGH* 136133
>CYP541B6 AAJI01002279.1 Ajellomyces capsulatus NAm1
98% to Histoplasma capsulatum G217B
HCB04326.1
55% to 541B1, 47% to 541A1
98% to HCB08024.1 Histoplasma capsulatum G217B (anamorph)
10797
MTTPIPGPPGVPLLGNIFDINPKDTWGSLKSLADKY (1) 10904
10960
EIYKVNALGHQIVFIGSAALLEEICDETRFRKCVTGPVVEIRRAVHDSLFTAYHHEKSWDV 11142
11143
AHRIMAPLVSPSAAEAMFTQMVECAATLVSRWTSDPGQRIDVTSDLQRSDLQSVLACYFN 11322
11323
QAANYFGGPEPSMIAAMQNSTLEAMKRPNRPKLLTRLLYQRKFDKDIKTMRSFAAEIIAN 11502
11503
RKSESAPKSDMLHALLNNPDPETGEVLGEERVIDEIITIFIGSATAPCLVSFAVYYLLQN 11682
11683
PEEIVKARDEIDSILGANGEITSSNLSSFAYCEAILREAFRLSAVAPAFNIEPIPSDEP 11859
11860
DEVQLAGGKYQISRKQPMIAVLSAVNRDPAVFDEPEAFKPERMLGEAYDKLPSGVKKGFG 12039
12040
NGKRRCFGKVPAWQWCLITLISILRKVDLTLANKDYKLASNGAFCVRPLEFFALA GPRER* 12222
>CYP541B7 Aspergillus niger
estExt_GeneWisePlus.C_21802|Aspni1
67% to CYP541B3v1
MPSPIPKPPGVFLLGNVKDVDAANPWNSFNKLAAKYRPICKVTILGVDIVLITGAALLEEICDETRFQKCVAGPIIEIRE
AVHSSLFTAKINDKEMSQWGVAHRIMAPLLTPGAVDQVFADMREVSTDLIKKWTAGPRQRINVTNDLDRLNHAANMLCFF
DQRLHCLEGPEPSLIKAMENATTEAVRRSSRLKLVNWLFYQRKFNAYNKTLRDYSASCMDYRRAHPSAKKDMLYALMEGK
DPETGEGLNDEQIVDEIINVFIGSATAPNLVAFGLYYLMKNPHVIKRAREEIDAVVGGPGAKIEHEHLSRLPYCLAIAQE
TMRLAAPAPGFNREAIPNQEGPVLLAGGEYEVPRKQALIAVLYGVNRDPAVFEDPDAFKPERMMGEAYERLPSAVKKGFG
TGKRVCIGKKYAWEWSYFTLVSILKDVEFELADKDYVTDGAGNNYNGAFTVKPLDFSAITGPRPRAG*
>CYP542A1 N. crassa
AABX01000017.1 cont3.568 NCU09103.1 EST = AA902060
114647
MASTTAFLPRLTTITFSFLTQPLLIMFLLSLLTLYTIYI
AYHRLYLSPLADIPGPRLAALTQWYEFYYEVILHGQYTF
KIIELHKQYGPIIRINPWEVHIADPDFHRELLPTNTNRR
RHRTPFFTKQFGAD (1) 114255
114135
ESIVATNDHDLHKLRRSAVGPFFSTQNTRALQPVIEERV
DALLARLREHGKTKKDIPLNMMYAYSATSY (1) 113929
113861
DIISEYCFAKSEHA (1) 113820
113745
VEDPDFRAEITNGILTGSNYGKIFQHFPFLVPFLASIP
PGMLAAISPFYRTFLHLRACITAQIGEIEKSLRSEEGK
NAHLDIPHPTIFHSFVNTEALPPIEKSVPRIAQEGQV
LVQAGTVTTSWALTISTFHLLDQHATALAKLRK
*LREALPDDADEPVELAR
LEQLPYLRAVIKESMRLSVGASGRITRVAPDETLRFK
PSKLCLRCYPDDQLKTTAEDKEKEWLLPPGTEVSMTSY
QITTNPEIFPDPHAFVPERWLGKENEMRLDKYMT
VFGHGARVCLGMQLAYAEMYLMLSKMWRVWEGGPQVGG
GEDEDGKEDVEEKKGRRDGRTTVGRLRLAEGVTVR
DAEMAEDWFIPVPYRGSKGVRVYFESY* 112624
>CYP542B1 old name = CYP580A1 Fusarium
graminearum FG08809.1 AACM01000355 FGcontig1.355_scaffold5
MDSNTIMAVQETIAARNWQQTGCFFAGVWLVY
IVALVVWRLWFSPLAHIPGPKLAALTQYYEFYYDFVLGGQYNYKIIDMHERYG
PIVRINPWEVHVGDPEFFSDLYT
SPSPSRRRDKWTFYTQQ(0)
SGAPRTQVPHPNALAAPKTATEGSLAAIDHGLNKLRRSALI
PLYTTQTVRELQPVIEERVEALLTAFMNYAEVSNGQPLDVMYPYSALTNDVINEYAFA
RSDHLVEKPDFGAEVTNDLLIGTHMGPCVQQLDWVLTLVNALPESISNRCMPGWGGFL
KMKNDIFEQIHSVDPPQSTGKWRMVGGHPTMLSTRARSTREKNASRQAQESQISVQGG
ALTTSWAMSLATFHLLNRPETLRKLRDELFAAMPDAYETVPLSRLEKLPYLRGVVKEA
LRLGIGTSSRLARVAPDEALVYHDRENGEDWNLPPGSIVGMSPYKTVMDESIFYDARG
FHPERWVEDGERLDKYLDIFCSGSRICLGMALAHAELYLTLAKLFRRWGSGGVVFGSD
DGDQRYGDVGYLSIFETRVRDCEIDADYFMPIPYKGSEGFRFSFETY
>CYP542B2 Nectria haematococca
e_gw1.1.1096.1
Necha1/scaffold_1:865645-867387
85% to CYP542B1 (old 580A1), 44% to CYP542A1
MAVPEIIASLTWQQTGCLLAGVWLIYLIQLVIQRLWLSPLAHIPGPKLAALTQYYEFYYDFVLGGQYTFK
IIDMHEKYGPIVRINPWEVHVGDPDFFSELYTGPSRRRDKWTFYTQQ
(0)
SGAPRTRVPHPNALTGPNTATEG
SLAAIDHSLHKLRRSALNPFSSTQTVRKLQPVIEERVDALLDAFLNYAEVSNGQPLDVMYPYSAFTN
(1)
DVINEYAFA
RSDHLVEKSDFGAEVTNDLLIGTHMGPCVQHLDWVLTLVNALPESISNRCMPGWGGFLKMKNDILEHIHS
IDPPQSTGKWTMDGGHPTMLSRPRSMRVKQSPQVQEGQILVQGGTLTTSWAMSLATFHLLNRPETLRKLR
DELFAAIPDAHDTTPLSRLEKLPYLGGVVKEALRLGIGTSSRLARVAADETLVYHDHVNNTVWRLPPGSI
VGMSPYKTVMDENIFYDARGFHPERWVEDGERLDKYLDIFCSGTRVCLGMALAQAELYLMLAKIFRRWGS
GGVVFGSDDGDQRFGDVGYLSIYETRVRDCEPAADFFMPIPYK
(0)
GSEGLRFVFEAY*
>CYP542B3 Fusarium oxysporum
91% to CYP542B1 Fusarium graminearum
FOXG_03513
MASNTFMAVQETIAALTWQQTGCLLAGIWLIYLVQLVIWRLWLSPLAHIPGPKLAALTQYYEFYYDFVLGGQYTYKIIDM
HERYGPIVRINPWE VHVGDPEFFSDLYTGPSRRRDKWTFYTQQ
SGAPRTRVPHPTALAGPKTATEGSLAAIDHSLHKLRR
SALNPFYSTQTVRELQPVIEERVEALLGAFLNYAEVSNGQPLDVMYPYSAFTNDVINEYAFARSDHLVEKPDFGAEVTND
LLIGTHMGPCVQQLDWVLTLVNALPESISNRCMPGWGGFLKMKNDILEQIHSVDPPQSSGKWMMDGGHPTMLSTKTRSVR
DKTASRQTQESQITVQGGTLTTSWAMSLATFHLLNRPETLRKLRDELFDAIPDAYETIPLSKLEKLPYLRGVVKEALRLG
IGTSSRLARVAPDEALVYHDRENDEEWNLPPGSIVGMSPYKTVMDENIFYDARGFHPERWVEDGERLDKYLDIFCSGSRI
CLGMALAHAELYLTLAKLFRRWGSGGVVYGSDDGDQRFGDVGYLSIFETRVRDCEIDADYFMPIPYKGSEGFRFVFETY
>CYP542B3 Fusarium verticillioides
98% to CYP542B3 Fusarium oxysporum = ortholog
FVEG_02379
MASNTFMAVQETIAALTWQQTGCLLAGIWLIYVVQLVIWRLWLSPLAHIPGPKLAALTQYY
EFYYDFVLGGQYTYKIIDMHEQYGPIVRINPWEVHVGDPEFFSDLYTGPSRRRDKWTFYTQQ
SGAPRTRVPHPTALAGPKTATEGSLAAIDHSLHKLRRSALSPFHSTQTVRELQPVIEERVEALLGAF
LNYAEVSNGQPLDVMYPYSAFTNDVINEYAFARSDHLVE
KPDFGAEVTNDLLIGTHMGPCVQQLDWVLTLVNALPESISNRCMPGWGGFLKMKNDILEQI
HSVDPPQSSGKWMMDGGHPTMLSTKTRSVRDKTASRQTQ
ESQITVQGGTLTTSWAMSLATFHLLNRPETLRKLRDELFDAIPDAYETTPLSKLEKLPYLR
GVVKEALRLAIGTSSRLARVAPDEALVYHDRENDEEWNL
PPGSIVGMSPYKTVMDEKIFYDARGFHPERWVEDGERLDKYLDIFCSGSRICLGMALAHAE
LYLTLAKLFRRWGSGGVVYGSDDGDQRFGDVGYLSIFET
RVRDCEIDADYFMPIPYKGSEGFRFVFETY*
>CYP543A1 N.
crassa AABX01000408.1
27399
MPCAFAITLLTVLVVLLVVQRWLERKRLRGGSRPLPGPT (1) 27515
27652 NLPFIGRVHDIPEKGSWLKFHEWSKVYGPIYQTKMFGVTHVWIS
SEKIAHDLLSRRANIYSDRPQIPNLPDNRTSGDYLALLGRN (1) 27906
27974
DTWRRQRKLCNHLMHTSALASLHDYPTLERNRFLYLLSQSP
ENYIEYIEQFTSRTIARLSWGSAHPAQILRHTTFGLLETIS
PSGALPNVISFLRHLPLALSPWQKKEKARHDLEDKQFRSNI
GFVKRMMDVGRAEPSFIRTYLEEQQGSINSTSTNKKCDEQK
GKEAAADEAMHVVGLMAIAGALTIGSPIQSYILAMCHYPEW
QARLQEEIDTELGGRCPMWEDREKLPLLRAVVKEVIRWRPPVPT (1) 28720
28825
GIPHAVEKDDVYNGYFIPAGATIHALEW (2) 28908
29018
AITRDEQTYPQAETFNPSRFLVPSYPTYREPLTIYPNLSGF
SQFGFGRRTCQGVPIVEQDLFLTMGGMAWAFTISKKRDPVTGVEMPVHWNDYT
PLLIAKPCRFPFDAVPRDEEKRKKMREMYEE
>CYP543A2 Magnaporthe grisea AACU02000514.1
revised
MASVPFVLFIAAWCLLIVKLYLDHQKRHRLPDGAKPLPGPKSIPFIGRVH
DLPPDMTWMKFYEWSKIYGPIYQMEIFGSVHIWMSSEEIVQDLLARRANI
NSDRPVIVNLPDNRTSGDYLALSGNNETWKRQRKMCNQLMAASNKQGLHA
YPTRERDRFLSLMANDPSNYIEWIEQFTARTVSRVCWGTPHRQALLRKTT
FGLLESISPAGALPNVVAWLGYLPDKFSPWRKKEHLRHALEAELFTSNLA
GVKASMNEGHSVPSAARTFLEDMEQKPRGSQAEADFHSAEGSKVVGMMAI
AGALTIGSPIQSFLLAMCHYPEWLERMQAEIDINLDGRCPQWDDREKLPL
LRAVVKETMRWRPPVPTGIPHASDKDDVYNGYFIPKGATLHALEWGLTRD
ESVYPDAETFNPDRWLNPSFPTYKEPLTHYPNLNGYSQFGYGRRTCQGIP
IVDQDLFLSMGGLAWAFDIRKKLDTQGNEIPVHWNSYSSLLIAKPVKFEF
DCVPREGKGRVIDLMASSAREMEEE
>CYP543B1 Mgr023 Mycosphaerella graminicola
40% to 543A1, 38% to 543A2 next best is 35% to CYP5445A1
yellow from JGI model
estExt_fgenesh1_pg.C_chr_40312|Mycgr3
MSQVVQAAQEPSRYAFEQSIDNATVLEPVSVDTPIPADFSILNSKAVLGFSLLVIILVTRLFGQKKKLPAGAKPLPKLPG
IPWIGRFWGIPISGAEAAWH
FGDFHKSYGPIYEWLTFGVTHIWIENDKIARDLLVHRGKLYGDRHELPAAVGVKGGSEILPLMGIGENFWRHKNFIHTIM
RHSSQAGFWDAPVTENKHTLRRLLDSPDTWSESIITHCARVVATIAWGDPKHGTKLLTVVPQLLKAVSPEGPLPNLLPFL
MHLPAAISPFKKAEAERKRIMQEAFYEAQQDVMARMKAGTAGQSWSRIWLENEKGMEKSKLDQHEAAHAVGTNSFVAIAT
IGSPLHSFFTAICHYPSWLPRIQEEVDRVCGDRLPTMKDIPNLPVVRAVCKETLRWRQPTPLGVPHITTEDDVYDGYFIP
KGAMVHANHYLISREEATYPEGNEWRPERWLEPSWPTYKEPLTEYPTLRGDPGFGYGTRSCPGTDLVMTELYTLIASLVW
AFDIKRKEGRAGYDNPVPWYETNPFVITMAKPFPCNITVRSEEKRR
>CYP543C1 Mycosphaerella fijiensis
44% to CYP543A1 N. crassa
e_gw1.1.178.1
MALVTLALAVTAILVVKYIEASRQERRSATRKLPGPRGLPLIGNIHQLPNKCSWLKFHEWAVKYGPIYQVNLAGTNHVWI
SRDKEAHDLLSKRSAIYSDRPFIPALEHDNRTSGQYLPLMSKNALWSRQRRFAKQIMERSQKDGFYSYPELEAIRLLFEL
INDPSAYNTSMESFVARVTSRLAWGTSVGADELKQRARELLIGVSPTGALGNKLPAVMSLPESLSPAKAWEHRRGRTERK
FFQTMQDNVRHSLDATEQLRMSWTRMFLENKRLWGFSDDLEGAFAVGMHGIAGALTIAAPMQSFCLALCHFPQHQAMLHE
EVDRVLGDRLPTTADMPKMPVLRAFIRETLRWRPPVPTGIPHALTDDDIYKGYHIPKGSVIHPLEWSISRDPEVFPDADT
WNPLRWLDSEYPTYQEPLTQFPTITQYSQFGYGRRICQGMGVAEADLFVGLGSVAWLFSISKEQEQEPGPAYVDNDPTLN
FSTLLIAKPLPFKFDLRVRNQARAEQVTRAFLEQKEKGEFEEERVFWKNNNQGDAEVG*
>CYP544A1 N.
crassa AABX01000494.1 cont3.721 NCU10011.1 (version3)
(GC BOUNDARY at
exon 2)
13303
MGIIHEKAHYVVAVALVAFLIRAFVLSQWNTIKRNGERLK (2) 13184
13120
KPPNTLPLVGNGLQFLQSRWKLFSWFDACQRKFGYETVAISVPT
LPPGVLIHDPRNLDYVFKNEGIFTKGNFVKGRTWDLFGNGIINA
EGDFWKTQRKAGLSFLNTANLRVLTDVALPQYLSESISQLRSST
NGTVVDLQHVFHEITTKLMGKMAYN (0) 12650
12590
MAMHADDEFTVSFDYASGG
TAERFQNPLWFVTEIFLGAELRKSIAVVKNFGRHIVTKAVQDRQEKEFGE
EEGKLDQISGSLIQSLLDAIQDEQMVADAALTYLSAGRDTTGQALTWTFY
LLMRHPRVVAKIREEATQLLKEKNVTLTPDQFDSSLFNPVTMPYSMAVFY
EVLRLYPPIPFEIRQCNEDVTLPDGTFLPKSSILVWCLWAMQRSKLTWGD
DADEFRPERFLDGNKLISRSPSEFPVFYGGPRTCLGRKMAEAIAAQVIPT
MACLFDFVPTSDEERTSKTSLTLPMEGGLPVTVKTLTGEEREKLVRIPEI
RFSEH* 11616
>CYP544A2 Magnaporthe grisea MG00452.4 58% to CYP544A1 AACU01001420 cont2.89
MTLLEFSPWAPAILVPVALIVLYTFLAAPRLKRNGIPLKTPRDSLPFVGN
GIVFLQPRQKLFAWFHQREREFGLETYQITVPTLPPGVVISDPVCLEYVF
KNETLFNKGAFFKERSDDLFGHGIINVDGEPWRAQRKAGLNFLNTTNLRV
LTDVALPRYLNENIGWLKNKADGETVADLQEVFHRITSQLMGKMAYNMEM
HAGDDFSVAFDYASGATAERFQNPLWFITEFFTGSRLRRSLAIVKEHGRK
IVANATCDRKAAEKLSATLPGVDADSEHDGLEEISGSLIQSLLDCIGDEK
LVADAALNYLSA (1?)
GRDTVAQ
ALTWTSYLLMQHPEAIERIRAETAELISPMDGSAGNHTTLLKPPSAPYTM
AVFYETMRFYPPIPFEIKQCVRETTLPDGTFLPASSVVVWCPWAMNRSKA
IWGSDVDEFRPERWLSLDGKSFASRSAAEYPVFNGGARMCLGKKMADIIA
VQVLPSIVTNFDFRPAYEKQQERVSKSSLTLPMQDGLPVFVKRRDVAR*
>CYP544A3 Fusarium graminearum FG08377.1
AACM01000335 FGcontig1.335_scaffold5
MALLSVNLRDGLILTAVITILLYIWEKKTAKITRNGEPLRKPPNTLPLVG
NGIIFLQPRQKLFSWFHRCERLYGYETLHITVPSLPPGVIVNDPQNLDFI
FRNEGVFEKGEFFKQRSWDLFGHGIINVDGEFWRLQRKAGLRFLSAAALK
TLTNEKLPKYLDQAIGVLEAKTNTKEVVDLQAVVHEVTTQLMGRMAYNME
MHADDDFTVAFEHASGGTAERFQNPLWFVTEMFTGARMRRSITTVKAYGK
RIVTSAVADRKEAEGKTQSDAPGSLIQSLLDSIGDETLVADAALNYLSAG
RDTVAQALTWTLYLLMKNPHVATKLRQSVESLRDEDTSTGDDPELLTPVR
LPYVLAVFYESLRLRPPIPFEIKQAQQATTLPDGTFLPAGAIVVWCAWAM
GRSHTTWGPNADDFRPERWLTTSLAGDVTVAQRPAAEFPVFNGGPRTLAR
LVPLFKFEPAFEGERVSKSSLTLPMEGGLPVYVQHQTPS*
>CYP544A4 Nectria haematococca
fgenesh1_pg.scaffold_1000764
Necha1/scaffold_1:2520778-2522398
77%
to 544A3 note 544A3 missing part of heme signature
This gene model seems correct
MTLFNITMERILLLIAVIAIILVAREKRTPKITRNGESLR (2)
KPPNTLPIVGNGILFLQPRQRLFSWFAQCE
RLFGYETLHISVPSLPPGVIINDPRNLDFIFKNEGIFEKGDFFKQRSWDLFGHGIINVDGELWRLQRKAG
LRFLAAPALRALTSVRLPEYLEQAVRALKEKAETKEAVDLQAVVHEITTQLMGRMAYNMEMHADDDFTVA
FEDASGATAERFQNPLWFLTELVTGGRMREAIAIVKAYGKRIVTSAVADRARAGDEKAQSDSPGSLIQSL
LDSIGDEGLVADAALNYLSAGRDTVAQALTWTLYLLTRHPHVTTTLRQSVQSLHDEVGVVSEKPLDPELL
TPTRLPYVLAVFYESLRLRPPIPFEIKQAQQATTLPDGTSLPAGAIVVWCAWAMGRSQTTWGPDADDFRP
ERWLTTSPSGDMTVTQRPAAEFPVFNGGPRVCLGKKMAELVAVQTLARLVPMFDFVPAFEGERVSKSSLT
LPMEGGLPVHVQYKSTSTVER*
>CYP544A5 Nectria haematococca
e_gw1.40.11.1
Necha1/scaffold_40:94653-96155
50% to 544A3 same gene as
fgenesh1_pg.scaffold_40000034
model is short at N-term added new exon 1
MLALYMLLLVLVLPLWVFMTERFKPSRIKRHGVPIR (2)
RSPGALPLLGNGLVFLRPRQKLFGWFTE (2)
CIQKYGQETLGIVIPILPPGVIIANPVNLDFIFK
HEELFKKGQFFRSRLQDLFGYGIVNVDGDLWRRQRAAGTHFFNGATMRTLKEIELPRALQQAMSQLDQHA
NIGTAVDLEAVLHELTTQLIGRLAYGVEMHAHDKFTKAFDHASFEIAKRFQNPLWRLTELITGGKLTESV
RVIKRYGQELVAQAVARRNGKYDERDLEERNAAPSLIDALFDSLGRQELVADSALNYLSAGKDTTAQALT
WTFYLLILHQGVAEKISRLVNSTESWSTQDSSCQSPRIQQNLSSETTHFILAVFYESLRLYPPIPFDMKQ
AQNYTTLPDGTFIPKDSVVLWCTWAMNRSVKTWGEDAHIFRPDRWLEGGRIKQSSTGDFPVFQGGARLCL
GKKMAELIAVQVIVALTRSFTFEQAFEGAKTSPTHLTLPMEDGLQVFIKHQCFERQREGTTV*
>CYP544A6 Fusarium oxysporum
75% to CYP544A4 Nectria haematococca
frameshift = &
FOXG_03445
MDYLSFVLEQPIVLSTTLLLFLYLLGKKSPKPTRNGKPLR (2)
RKPPNS
LPLVGNGIMFLQPRQRLFSWFHRCERLYGYETLHITVPTLPPGVIINNPQNLEFIFRHEG
IFEKGEFFKQRSWDLFGHGIINVDGEFWRLQRKAGLRFLSTAALKTLTSDRLPEYLEHAI
HVLKGKEAERDVVDLQAVIHEVTTQLMGRMAYNMEMHADDDFTVAFEHASGATAERFQNP
LWFVTEMFFGTRMRRSIRTVKAYGQRIVKSAVADREETEGKTQSDAPGSLIQSLLDAIGD
GDLVADAALNYLSAGRDTVAQALTWTLYLLMKHPEVTNKLCQSIQDLRDEVRDQDHSEND
PELLTPVRLPYVLAVFYETLRLRPPIPFEIKQAQQETILPDGTFLPKGAVVLWCAWAM
&
GRSHTTWGPDADEFRPERWLTTSPSGDVTVMQRSAAEFPVFNGGPR
VCLGKKMAQLVAVQ
TLARLVPLFDFKPAFEGERVSKSSLTLPMEGGLPVYVHARKTSETS*
>CYP544A6 Fusarium verticillioides
94% to CYP544A6 Fusarium oxysporum = ortholog
FVEG_02317
MHYLSFVLGQPIVLSVTLLLFLYLLGKKSPKPTRNGKPLRKPPNSLPLVGNGIIFL
QPRQRLFSWFHRCERLYGYETLHITVPTLPPGVIINNPQNLEFI
FRHEGIFEKGDFFKQRSWDLFGHGIINVDGEFWRLQRKAGLRFLSTAALK
TLTSDRLPEYLEQAIHVLEGKEAGRDVVDLQAVVHEVTTQLMGRMAYNME
MHADDDFTVAFEHASGATAERFQNPLWFATEMFFGTRMRRSIRTVKAYGH
RIVQSAVADRKGMEGKTQSDAPGSLIQSLLDAIGDDDLVADAALNYLSAG
RDTVAQALTWTLYLLMKHPEVTNKLCQSIQDLRDEVSDRDRPEDDPELLT
PARLPYVLAVFYETLRLRPPIPFEIKQAQQETILPDGTFLPKGAVVLWCA
WAMGRSHTTWGPDADEFRPERWLTTSPSGDVTVMQRSAAEFPVFNGGPRVCLG
KKMAELVAVQTLARLLPLFDFRPAFEGERVSKSSLTLPMEGGLPVYVHARTTSET*
>CYP545A1 N.
crassa AABX01000329.1 cont3.414 NCU07092.1 (version3)
9756
MQLLTLVIVGLFMLIVAVVHFIKAFREVNDPNGI
PGPTQIPYLGRVHDLPIQFMWLKFKEWADKYGQQGFYRTMMLGAEFIVVT
DEKVAEDLLVKRAKYNSDRPVIQSLFDSKSTHGSMEYLPLM
(1) 9382
9297 AYWARQRKLS
HSYLTEATKAHYYGVMYFEVQRWMARLLENPEDFQHSIEDMSSKVMCQLTWDDP
SLSEYCTKSAWGLLTQMSPAGPITNVLTPLWHLPTLINPWKRAERKRHDE
QQAWWMERLLTCREKLARGELRPCWTRQFLEKTSQKTSISGDYEASCVIG
MLALVGIFTVVGPMSYWLVSMVHNPKWQEAVQREVDEVCGNRMPRLEDAP
RLPILRACIKETMRWKPNVPTGVAHETEADDHYQGYFIPKGTRILPFDW
(2) 8509
8448
SFLRNPVKYPDPENFRPERWLEPGWPTYKEPLTQYPTIKGLTSFGWGQRQC
LGMSLTQDELIVGCGALAWLFNLRHKRDPITGRELPVPLDRSNSLLIIKP
DPFQMEFEPRSKERKKEALRVWKESEAKDRARRERWLRNVKEGKPNVIKE
PKVLQPTVKIPSPSPAAAVPAALVDGGEVRDELSKTVQVVKEKSGGVNGH
GDSLAEKAVMDVKKKADISITIARLDSTACVY*
7747
>CYP545A2 Mycosphaerella fijiensis
62% to CYP545A1 N. crassa
e_gw1.1.252.1
MQTLTIVAALVAFIGFAFFSLLNAARSSHPWKTKASEPPGPALVPWIGRIHDLPIQLMWLKFKEWADQYGPIYRTKMLGA
TFIIISDEKIAEDLLVKRAKVFSDRPEMKSLFDSKSTTGTMEYLPLMGKNEYWARQRKFTHSYLTEATNARYYGIMNHET
KRWLKRLLDDPDNFGFQLEDMASKVMCQLTWDDDSLSEAMTPSAWGLLTQMSPAGPITNVITPLWDYLPETINPWKRTER
KRHDEQQRWWMDNLVNVRTKLAKGLARPSFTRTYLEGLQNGKTGGLSGDYEASSAIGMMALVGVFTVAGPLYYFLLAMVY
HPEWQRKCQREIDEVCKGQMPDISDMPNLPVLRACIKETMRWRPNVPTGVAHEAEADDFYEGWLIPKGARILPLDFAFMR
NPEKYPDPEAYRPERWLEAGWPTFKEPLTQYPTIMGMSSFGYGQRQCLGQSVTRDETLVACGGLLWGYNLKKKLDSNGIE
INPPLDKSNSLLIVKPDPFEMAFEPRSDSRRDEILQNWKKTDLEDRTARAAFISKATESEKASAVPCRVDSMDPANDYFK
VQHATVAATA*
>CYP546A1 N.
crassa TWO PIECES AABX01000340.1 cont3.411
16866
MLSDKLLDLFALHKTQEALADVNLYKLLVLALALVLTAIIIDYG
YMLWLRSKMPTGPFPWPIIGNTFSLPENKPWIYFEELSKKYEKP
LITFWIGR 17153
(2)
17210
NPTIWINDAWCAHEILEKKAQIYASRPRMVVFGELGTGQKNLVT
MRILNNNDRDRWRIHRKLMHLGVGIQSVRGYREIQNNESKVVAL
DYLREPKEYVKHLERYATSVVSVIAFGRRVASYDDPIITEVIAL
MQLAADLNVPGKRFPMLLETFPXXXXXXXXXXXX 17671
145
RGGGQKGGGGGHYFFHSLALEALAQYESKSPLAKASMPTPYIKTLM
283
DASRQYSLPEAELSSLTGNLFGAGSDTSSSTLITFMLSCLAFPDA
MHKAQAELDRVLGGPAGGRSPHWDDAPNLPYINAYVKEVLRWRSV
AIIGGQPHSNTSPDYYKGYFIPPHSWVQGNVWAIHHHEREFPDPD
RFYPDRYLPGNDHHRPFPGEKGYMTFGWGRRVCSGQALAEQGTWI
SVARLLWGFTIRKYRDPQTGKEEEVDIFAYTNGLNMRPQPFRCEI
VPRSEEIREIIVREGEQALRDLKVLDGENRYRMSTFYQQKKREVA
EMPEFDEKGNIRMVKVK*
1146
>CYP546A2 Magnaporthe grisea MG06557.4 64% to 546A1 AACU01000188 cont2.1218
MIFDRLTSQASLAKLEDVISNVPSSKLITLSVLIIAVTALIIDYGYMLYL
RSRMPPGPFPLPIIGNTFSLPDNKPWVWFDELSKRYNAPLVTIWIGRNPT
VWICDAWCAHDMLEKKAQLYSSRPRMVVFGELGTGQANLVTMRTRNQAER
DHWRVHRRLMHLGVGTQVVRRYRGVQDAESRVVALDMLRDPAAFVSHLER
YATSVVSILAFGRRVASSSDPIITEVIAVMQLAAELNVPGKKFPMLMETF
PILAKFPRSMPWMKGLGARGRKGGHYFWHSLAQEAVEQLDSRTDEERRNI
PKPYVHTLFAENDKYKISTEEISNLTGNLFGAGSDTSASTLVTFVLACCA
FPEPAHKAQRELDRVVGHGRSPSFGDQADLPYVNAFVKELLRWRPVAIIG
GQPHSPTADDDYKGWRIPANSWVQGNLWAIHRNPRDFPDPDRFEPDRFVE
GSEWQRPFPGDRGYMPFGWGRRVCSGQALAEQGVWITVARLLWAFDMRKK
RDPVTGAEVPVDIFAFTNGLNMRPQPFLCDITPRSEEIRRTVESEGLDAL
VELKPLDGESRYRFSTYYQQKKKESG* 74634
>CYP547A1 N.
crassa AABX01000481.1 cont3.599 NCU09419.1 (version3)
16175
MPPTGNPFNFARITLLALVEVLIVKKTSYRHVLAISTTSLVLAILAINYV
FFLAWKLYLYPVYFHPLSKFPAPKVVDLWRVLARFRGKVPPGQLLLELAE
RTPNDGIIILQGGFGTSMLITKPAPLADILVHHPYDFVKHDAIRNFLRPI
LGDGLVIVEGEQHRFLRKNTQPAFKFGHIKELYSTMWTKAIEMNHVLKEE
LREKGNDTSVEINAWAGKVTLDIIGIAAFGRDFHVLERPDHPLVKNYADL
LEPGPAKFAYFFLALTLSRKFVDLFPWEISRRFNRTTSNIRRICAELVRE
RKAAIEKLGDDQFDILSLLIRSNNFSEAELADQLLTFLTAG
(2) 17197
17248
HETTSSAFTWAVYKLAQDGEMQSTLRSELKRALPDFPRFAPGQD
IAIILEHLPYLNGVMNETLRLYPTVPMTVRTATCDTTVLGHPIKKGTEIM
ISPWLINRYSDNWPSASTEFVPERWIDQEGKHIAEDGTEQPTQKPNNTGG
VTSNYAQMTFLHGPRSCIGQGFAKAELRCLLATFVLAFEWKLGMDEKDVM
PDGVITIKPNNGMHLILRSLDGHQKG*
17910
>CYP547B1 Fusarium graminearum FG11303.1
AACM01000464 FGcontig1.464_scaffold9
MAVMSKLLNFPSLTLAACIEGFFAIKLFPNYYSTQSHLAAVVTILLINYA
FGVVFWAVLYPRLFSPLRRIPGPKAYLSAAHHSLVVKGRPSGDLFLDLAK
EYPGKDVIMLNSFRNQLCIMNPQLLADLLVHNCYDFAKPKRISGFLRHVL
GDGLIIVEGEQHKFLRKNSTPAFHFRHIKELYPMMWTKSETLTKAIAQDI
TASRSPVVELNGWASKVTLDIIGIAGLGRKFDAVEKKIDPLADIYEQLLE
PDREKLIFAMLSLAIGLPIIRMIPWKMNDLFNYLTGSLNDLCYPMIKEKK
AAIIEKGDDHFDVLSLLIKSNNFSDEALKDQLLTFLAAGHETTASALTWA
CYLLTQYPDIQSKLRDEVRDSLPADVDCNTPDLASILEQMPYLNGVMHET
LRLYPTVPLTMRSALRDTRIGDQYIPEGTDVIVSIWYINRAPEIWGPDAA
EFRPERWMTEDGKPNQNGGASSNYNFLTFLHGPRSCIGQGFAKAEMRCLL
ANMVKSFEWTLAMDNKLVLPRGVITIKPENGMYLNMKAI*
>CYP547B2 Nectria haematococca
e_gw1.60.8.1
Necha1/scaffold_60:53804-55237
77% to 547B1, add N-term exon and extend exon 2
MTVVSKLLTFPNLTLAAIVESLLVIKLFPSYYSSQSHVAAVATILGVNYAFGILFWALLYPVLFSPLRRIPGPR
(0)
AYLSAAHRALVVKGRPSGDLFLDIVEQYPGQDLISLNALRNQIFVTNPRLLADVLVHRCYDFAKPTRISSFLRHILGDGL
IIVEGDQHKFLRKNTTPAFHFRHIKNLYPMMWNKAEILTRTLNQEISTTRSPVIELSPWASKVTLDIIGI
AGLGRKFDAVEKKQDPLAGIYEELLEPDREKLIFAMMALALGLPFVRLIPWKMNDLFNHLTGSLNNICRP
MIQEKRVAITEKEDDHFDVLSLLIKTNNFSDEALKDQLLTVLAAG (2)
HETTASALTWACYLLTKHPEIQQKL
RDEINEALPQDVESDSTIDLAGILEPLPYLNGIMHETLRLYPTVPLTMRQALCDTRIGDQFIPEGTDIII
SIWYINRSPEIWGPDAGQFRPERWITEEGKPNQNGGSSSNYDFETFLHGPRSCIGQGFAKAEMRCLLAAM
VRAFSWTLAMDDRLVLPRGVITIKPESGMYLKLTPLAPSI*
>CYP547B3 Fusarium oxysporum
80% to 547B1 Fusarium graminearum
FOXG_13409
MAVVSKLLGFPSLTLAAVIESFVAIKVFPDYYDSKSHLAAVFTILLVNYAFGIVFWGFLYPVFFSPLRHIPGPREYLSAA
HRSIAVKDRPSGDLFVDIANRYPGEDLLTLNSFRTHILVTNPQLLADLLVHNCYDFTKPKRISSFLRHILGDGLIIVEGE
PHKFLRKNSTPVFHFRHIKELYPMMWEKSQSLARAIQQDMTTSRSSVVELNSWASKVTLDIIGIAGLGRRFDAVEKKKDP
LADIYEGLLEPSREKLIFSGLALAIGLPIVRLIPWKMNDVFNYLTGTLNELCYPMIQEKKAAIIEKGDDHFDVLSLLIKS
NNFSDESLKDQLLTFLAAGHETTSSAITWACYLLTKHPEYQAKLREEVRNGLPEDLAANPTVDLAGILEQLPYLNGIMHE
TLRLYPNVPLTMRSAIRDTRIGDQFIPEDTDIMVSIWYINRSEAIWGPDATEFKPERWITDDGKPNQNGGASSNYNFLTF
LHGPRSCIGQGFAKAELRCLLATMVRSFEWTLAMDDKLVMPRGVITIKPENGMYLDLKAL*
>CYP547B3 Fusarium verticillioides
95% to CYP547B3 Fusarium oxysporum = ortholog
FVEG_11844
MAVVSKLLGFPNLTLAAVIESFIAIKVFPDYYDSKSHLAAVFTILLVN
YAFGIVFWGFLYPVFFSPLRHIPGPRDYLSAAHRSIAVKDRPSGDLFVDIAN
RYPGEDLLTLNSFRTHIMVTNPLLLADLLVHNCYDFTKPKRISAFLRH
ILGDGLIIVEGEPHKFLRKNSTPVFHFRHIKELYPMMWEKSQSLARAIQQDM
TTSRSSVVELNSWASKVTLDIIGIAGLGRRFDAVEKKKDPLADIYEGLL
EPSREKLIFSGLALAVGLPFVRLIPWKMNQVFNYLTGTLNELCYPMIQEKK
TAILEKGDDHFDVLSLLIKSGNFSDEALKDQLLTFLAAG
HETTSSAITWACYLLTKHPQYQAKLREEVRNGLPEDLATNPTVDLAGILEQLPYLNGVIQETLR
LYPTVPLTMRQAIRDTRIGDQFIPEGTDIMVSIWYINRSEAIWGPDATDFKPERWITDDG
KPNQNGGASSNYNFLTFLHGPRSCIGQGFAKAELRCLLATMVRSFEWTLSMDDKLVMPRGVIT
IKPENGMYLDLKAL*
>CYP547C1 Aspergillus nidulans AN8895.1 38%
to 547A1
43% to 547B1 547 clan, 73% to 547C3, revised
7/18/07
MIPMLAATLAEAFILQRSVFTDTPLRTVVFGSAAVNLLILAIYNVWIWPF
FLDPLRHLPRAPGRFNMLRFIFDNPRGRLPLLWMKTVPNDGLIYFRDLLN
RTQLLATNHQALLDVMSTNTYDFEKPWRAREFLARIIGFGLILSEGAAHK
RQRRALTPFFTIKNVRALYTLMWDKTNQLLVEMDKQISRCPMEGTSPDSG
WGKVEMSVWARYFTLSRLTLDVIGPAAMGRDFRSLQNAENKVADSFLAIL
EPTKEKIAFLAINFLLPQWFAKKLPWRLNQVIEEQVGYLRDLCKEIVHEK
RAAITATKVTASELEADILGSMMLSGDFTDDELVDQMLTFLAAGHETTAS
ALTWTCYLLTLHPEVQDRLRAEIRTAIPHSTHPVTHSDLESLPLLNGVCQ
EVLRLYPTVPSTIREAVRDTTVAGKHVPKGTKIMLCPYAINRAPEFWGAD
GDAFRPERWIDTDPVTGKTSVNNHGGAATNYAQITFLHGQRSCIGKDFAR
AELRCAVAGVVGRYEFAMQDPKQ
VIHISGAVTTKPVEGMHLRMRRVEGW
>CYP547C2 Aspergillus fumigatus
AAHF01000014
MADTLLAIASVSLAEGYFLQRSVLKEYSFHSVCLGAVGVNLALK
IFWDFIIYPFFITANRHLPTVKGTFVNGKVIFDNPRGRLPLQWMKTIPNEGLIHFRDV
FNRSHLLPTTHQALLDIMSTNTYDFEKPWRAREFLARIIGFGLILSEGAAHKKQRKAL
TPAFNIKNIRSLYSLMWEKTGLFLDELEKEIRQNPMEGTSPEDGVGKVEMSMWAR
(2)
LPSRLTLDIIGPAAMGRDFRSLHNPENKVADSFLAILEPTKEKMAFLAINFILPQWFARRLPWR
LNNVIDTETGFLRDLCKDIVREKRNTIVSSNMTAKELEADILGTMMVGGDFTDDELVD
QMLTFLAAGHETTASALTWACYLLTLHPDVQERLRTEIREHIPSGNHPISWSDLESMP
LLNGVCQEVLRLYPTVPITIREAVRDTTIAGKHVPKGTRILICPYAINRSPEFWGDNG
EEFLPERWIDHDKNGQKVVNHNGGASTNYAQITFLHGQRSCIGKDFARAELRCAVAGV
VGRFKFEMQDPKQEIHIAGAVTTKPVEGMHLKMSRVDEW*
>CYP547C2 Neosartorya fischeri
97% to CYP547C2 Aspergillus fumigatus =
ortholog
NFIA_096320
MADTLLAIASVSLAEGYFLQRSVLNEHSFHSVCLGAVGVNLALKIFWDFVIYPFFITANRHLPTVKGTFVNGKIIFDNPR
GRLPLQWMKTIPNEGLIHFRDVFNRSHLLPTNHQALLDIMSTNTYDFEKPWRAREFLARIIGFGLILSEGAAHKKQRKAL
TPAFNIKNIRSLYSLMWEKTGLFLDELEKEIRQNPMEGTSPEDGVGKVEMSVWASRLTLDIIGPAAMGRDFRSLHNPENK
VADSFLAILEPTKEKMAFLAINFILPQWFARRLPWRLNKVIDTETGFLRDLCKDIVREKRKTIVSSNMTAKELEADILGT
MMVGGDFTDDELVDQMLTFLAAGHETTASALTWACYLLTLHPDVQERLRTEIREHIPSGNHPITWSDLESMPLLNGVCQE
VLRLYPTVPITIREAVRDTTIAGKHVPKGTRILICPYAINRSPEFWGDNGEEFLPERWIDPDKNGQKVVNHNGGASTNYA
QITFLHGQRSCIGKDFARAELRCAVAGVVGRFRFEMQDPKQEIHIAGAVTTKPVEGMHLKMSRVDEW*
>CYP547C3 Aspergillus oryzae
GenEMBL BAE66568.1
73% to 547C1
MDLMLALITLSLVEGFLLQRTVFVDLTFRTVTLSSVGVNLVLLTIWNTLIYPYFVTPLRHLPTISGNLNN
ARIVFDDPRGRLPLEWMKTVPNEGLIHFRDIVNRSYLLATNHQALLDIMSTNTYDFEKPWRARDFLARII
GFGLILSEGSAHKKQRRALTPSFNVKNIRALYSLMWEKTGLLMDELEKQIKQNPMDGTNAQSGEGKIEMS
VWASRLTLDIIGPAAMGRDFRSLHNPENKVADSFLAILEPTKEKMAFLAVNFALPQWFARRIPWRLNKVI
NDETGFLRDLCRDIVHEKRASITATKATAKELEADILGTMMLGGDFTDDELIDQMLTFLAAGHETTASAF
TWACYLLTLYPDVQERLRTEIRERIPSGNHPITWSDLETLPLLNGVCQEVLRLYPTVPMTIREAVRDSVV
AGKHIPKGTRILLCPYAINRSPEFWGNDGEEFRPERWIDTDKN
GQLVTNNTGGASTNFAQITFLHGQRSC
IGKDFARAELRCAVAGVVGRFRFEMQNPKQKIHIAGAVTTKPVEGMHLRMSRVDDW
>CYP547C3 Aspergillus flavus
100% to CYP547C3 Aspergillus oryzae
AFL2G_11890 revised
MDLMLALITLSLVEGFLLQRTVFVDLTFRTVTLSSVGVNLVLLTIWNTLIYPYFVTPLRHLPTISGNLNNARIVFDDPRG
RLPLEWMKTVPNEGLIHFRDIVNRSYLLATNHQALLDIMSTNTYDFEKPWRARDFLARIIGFGLILSEGSAHKKQRRALT
PSFNVKNIRALYSLMWEKTGLLMDELEKQIKQNPMDGTNAQSGEGKIEMSVWASRLTLDIIGPAAMGRDFRSLHNPENKV
ADSFLAILEPTKEKMAFLAVNFALPQWFARRIPWRLNKVINDETGFLRDLCRDIVHEKRASITATKATAKELEADILGTM
MLGGDFTDDELIDQMLTFLAAG HETTASAFTWACYLLTLYPDVQERLRTEIRERIPSGNHPITWSDLETLPLLNGVCQEV
LRLYPTVPMTIREAVRDSVVAGKHIPKGTRILLCPYAINRSPEFWGNDGEEFRPERWIDTDKN
GQLVTNNTGGASTNFAQITFLHGQRSC
IGKDFARAELRCAVAGVVGRFRFEMQNPKQKIHIAGAVTTKPVEGMHLRMSRVDDW
>CYP547C4 Aspergillus niger
fgenesh1_pm.C_scaffold_14000128|Aspni1
75% to CYP547C3
MDSLVLLGASLVEGYLLQHSLLPDWAFRSVTLLALAGNLILRLVWGVVIYPYWVTPLRHLPTLPGNLNHARVLSDDPRGR
LPLRWMKTIPNNGLIHFRDIFNRSFLLATNHQALLDIMSTNTYDFEKPWRTREFLARIIGFGLILSEGSAHKKQRRALTP
SFNVRHIRALYGLMWEKTGLLMDELQKEMDANEGCVEMSVWASRLTLDIIGPAAMGRDFRSLHNPENKVADSFLAILEPT
REKIAFLAVNVLLPQWFARKLPWRLNKVIDTETGYLRDLCKDIVAEKRAAILETKATAAELEADILGTMMLGGDFSDDEL
VDQMLTFLAAGHETTASAFTWACYLLTLHPTYQPLLRDEIRSRIPTASSPITHADLESLPLLNGIVQEVLRLYPTVPLTL
RESIRDTTVANTAIPKGTRLLLCPYAINRSPEFWGEDADMFRPERWVDTDKEGNQIVNGHGGAGTNYAQITFLHGQRACI
GKDFAKAELRCALAGVLGRYEVEMKDPTQVIHIAGAVTTKPVEGMHLRMRRVEGW*
>CYP547C5 Aspergillus terreus
82% to CYP547C3
ATEG_10355.1
MDSLLAAILLSLLEGFFLQRTYLGEYTFRTVTLGAFGVNLLLLAIWNLLIYPYFITPLRHLPTVPGNLNNARIIFDDPRG
RTPLHWMKTIPNDGLIHFRNLLNTSFLLATNHKALLDIMSTNTYDFEKPPRAREFLARIIGYGLILSEGAAHKRQRKALL
PSFNFKNIRAMYALMWEKTGLLMDELEREIALHPMDGTRPEDREGKVEMSVWASRLTLDVIGPVAMGRDFRSLQNTENKV
ADSFLAILEPTKEKMAFLAVNFVLPQWLAQRLPWRLNRVIENETTFLRNLCKDIVQEKRATIASTKATAEQLEADILGTM
MLGGDFSDDELVDQMLTFLAAG (0)
HETTASAFTWACYLLTQHPDIQDRLRAEIRARIPSGNHPITWSDLETLPLLNGVCQEVLR
LYPTVPVTLREAIRDTTVAGTHIPKGTRIILCPYAINRSPEFWGADGEAFRPERWIDTDK
NGQPVVNHTGGASTNFAQITFLHGQRSCIGKDFARAELRCALAGVVGRFRFEMQDPKQEI
HIAGAVTTKPVEGMHLRMARVDEW*
>CYP547C6P Aspergillus clavatus
65% to CYP547C2
RSPMGSCWQVSLLPSLRAGIAGRFRFEMQDPKQQIHIADAVTAKPVEGMHLKMSRIEGW*
>CYP547C7 Aspergillus terreus
54% to CYP547C5 Aspergillus terreus
ATEG_03033.1
MSSAAEQLAFLIPVTVVETFAVTATRMVPEQKPTSVFLYALGLNLVLLAIWNIFVWPFLVNPLRHLPTVRGPFIGASIFL
RHPRGSVTIPWLRTIPNEGLIHFREGLNRSFLLVTNQRALMDVLHTNSYDFTKPRGGREFLARGLGYGLILSEGDAHRAQ
RKAVTPAFAIKNIRAMYDLMWSKTQIFLHQLDREIQLHPVPGMKSGASGYVELGSWASRLTLDIIGPAAVGRDFQSLENE
DDPVSQAYSAILKPSSDTLLLFALSVLFPQWLVKLVPVRANIELPRRISYLRRVFHDILREKRTQLTEKPSDVDGDILGT
MMRGGEFSDSELVDQMLTFLAAGHETTANALTWASYHLALNPHIQETLRAEIRATVPSADAAVTWQQLESMPYLNGVMHE
VLRLYPTVPMTGREAIRDTTIAGQKIPRGTIISICPQSVNRSPEFWGDTADDFRPERWIDTDPVTGRQTPNKHGGAGTNF
AQITFLHGPRACIGKDFAKAEFRCAAAGLFGRFKAELQEGCVVKFGGTLTAQPVRGMPLRLTRLEGW*
>CYP547D1 Mgr008 Mycosphaerella graminicola
46% to 547B1
MAPPITVIGLLVTAVEAFVVASLFADHLPEHPLLRVFFRLLALNVGGYALYRIVIYPRLLTPLRNLPRPKGGKLLIGHGM
VTFERPNGVTFLKWMKEIPNDGLIYFRGFFNADRLIVTNGKILAELLVAKSYEFTKPAPVRSFLRNILGDGLIIVEGDDH
RFLRKNMMPVFSYRHIKNIYPLFWEKSVQLMDCVGQEIAEKESSNKNDTAVVEVNHWATKVTVDIIGMAAMGRDFQTLKN
TQDPLVEVYEELLEPTFEKQLFFLCQLMLPQNLVKKLPWKLNQTTEKCVNTLNTVTGQLVQDKKQSIKTESDSHKDILSN
CLKTGSFSDPQLVDQLLTFLAAGHETTSSALTWTTYLLATNPEIQTALRKELRDAIAIPTSPLPEDFDLASVLESLPLLN
GVCNEALRLYPTVPLTVRTSEKTTTLGNQTIPAGAQIILPIYAMNRLPEFWGADADQFTPERWIDTDEKSGERRPNNSGG
APSNYVNLTFLHGPRSCIGQGFAKAELRCLVAALAGRFEMEMADPNEDVIPAGVITTKPKNGMNLKMKLVEGW
>CYP547D2 Mycosphaerella fijiensis
63% to CYP547D1 Mycosphaerella
graminicola
estExt_Genewise1.C_60812
MTSLPPSAVLVLASAVESAVAVALFPQHLPEHPLLYIFVRLLGVQTVAYAIYSIFIWPFFLSPLRHLPGPKSRNPIIGHG
MTMFEKPAGASFLTWLKTIPNDGLIHFRAFLNADRVLVADPKALQEILVTKAYEFEKPEPLRNFLRFVLGDGLIIVEGDS
HKFLRKNLMPVFSFRHIKELYPIFWSKSTQMIDGIAQQVRESAGPGESKTSVVEINHWATKVTVDIIGLAAMGRDFQALK
NSDDPLIQVYEELLEPTMEKQVYFVSQILGPAKLIRKLPLKLNERSEVIVRTLTDICLKLVREKKELIKTEPADHKDILS
LCIRSNNFSDEQLVDQLLTFLAAGHETTSSALTWTCYLLAKHPEIQTALREEIHRTIPSPNQPPPSDTDLAQIFESAPLL
NGVCNESIRLYPTVPITVRINPKPTTLAGHVIPKNTQFLLSPWAINRNPAYWGADADEFTPYRWIDTDEKTGEKRPNNSG
GAPSNYAILTFLHGPRSCIGQGFAKAELRCLVAAIVGSFEMTLANPEEKVVPHGVVTTKPKNGMHLVLKPLGPW*
>CYP548A1 N. crassa
AABX01000409.1 cont3.400 NCU06895.1 (version3)
71638 MVFGAAHLQLWLGALVVLGAVY
(0) 71703
71769
TSCLIFYRLFLHPLAKYPGPFLAKLTDG
YMAYHAFKGDRHLEFWRMHEKYGKFVRFGPNSLSVNSNTALKDIYGFKAN
VRKAEFYDAFVHPAPNTHNARDRDLHARKRRVLAHAFSDSAIKEVERYIL
SNIRTFCDAIGDLGRPSFAPLADKKGWSSPKNMSDWCSWLAMDILGDLCF
GKAFHMLERPDNRYAVDLVSVAAHRHLICGTMPMLDKLSLDRIFLRKIAS
GRAQYMAYSRQQLAERTALGDETDRRDFFYYLLKARDPETGQGFTTPELW
GESNLLIIAGSDTTSTAMAATLFYLVRNPTALARVTAEIRSRFASVEGIH
QGPSLQSCTYLRACIDEAMRLSPSVGGLLPREVLPGGITIDGEHVPQGTI
IGVPHYTIHHNAAYYPDPWSYTPERWLSTRSPSEKTSGAAMQTEEQIQLA
QSAFCPFSIGPRGCIGKGLAYIEMSITLARVLFLYDLRRAVGVDDPAEGG
KKGAEYGRHRVGEMQLVDTFTSTKDGVMVEFRPREDLAA*
73322
>CYP548A2 Magnaporthe grisea MG03375.4 74% to CYP548A1 AACU01000699.1
cont2.663
MENLCTWLGLLAGAVFL (0)
124757
TSCLVVYRLYFHPLAKYPGPFLARISDVYQLYHAWRGDRHLEFWRMHQKY 124608
GKVVRFGPNCISVNSATALKDVYGFRANVRKAEFYDAFVHPAPNTHNARDRD
LHARKRRVLSHAFSDNAIKQMERYILANERTFCAEIGRGASPDSKGWSTP
KNMSDWCNYLAMDILGDLAFGKAFHMLESEDNRYALDMVGAAAQRHLICG
TMPIIDKLSLDKVLFPKIAAGRAKYMKYSRAQLTERTKLGDETDRRDFFY
HLLRARDPETGQGFSTPELWGESNLLIIAGSDTTSTAMAATLFYLCRNPA
ALARVTEEVRTAFSSVEDIKQGPQLNGLTYLRACIDEAMRLSPSVGGILP
REVLAGGITVDGETLPEGTVVGTPHYAIHHNEDYYPDPFAYAPERWIAGS
VLKSGRTVGEADIQAAQSAFCPFSVGPRGCIGKGLAYVEMSTTLARTLFT
YDMRKAVGVEDPSEGGKPGAEWGRHRESEFQLVDTFTSLKEGPICEFRER
DLSA*
>CYP548A3 Fusarium graminearum FG06068.1
AACM01000241 FGcontig1.241_scaffold3
MTVDLAHLWVYLGLLVGGGLFYGFSIVIYRVFFHPLAKYPGPFMAKITDA
YQLYHAWKGDRQIEFWRMHEKYGPVVRFGPNLVCFNSNKALKDIYGFRSN
VRKAEFYNAFVHPTANTHNTSDKEVHARKRRVMSQAFSESAMKEMQRYIL
GNVRTFCEQIGMLEGSGEDNKGWTKPRKMSDWCNYLAMDILGDLCFGKAF
HMLESPTNRFALQLVEAATTRHLLCGTMPIVNKLNLDKILFPGLAAGRAR
YMAYSKGQLTERTKLGEETDRRDFFYYLLKARDPETGQGFSTPELWSESN
LLIIAGSDTTSTAMAATLFYLVRCPRALKRVTEEIRSKFNDVEEICQGAT
LASCTYLRACIDEAMRMNPSVGGILPREVLSGGMTIEGHVIPEGTVVGVP
HYTIHHNESYYPSPYEYVPERWLVGTLNPLTGQNTTEAEVALASSAYCPF
SVGPRGCIGKGLAYVEMTNTLARTMYMYDMRKAVGIVDPAEGNPKNEWGR
HRPGEMQLVDIFTSAKNGPMVEFRKADHMSS*
>CYP548A4 Nectria haematococca
fgenesh1_pg.scaffold_3000360 same as
e_gw1.3.949.1
Necha1/scaffold_3:1057950-1059702
MQLDLGHLWIYLGLLVGGGVLY (0)
TFGLVVYRVFFHPLAKYPGPFLAKITDAYQLYHAWKGDRHLEFWRMHQ
KYGPVVRFGPNSLCFNSNKALKEIFGFRTNVRKAEFYNAFVHPTANTHNTRDKEVHARKRRVMSQAFSES
AMKEMQRYILANVRTFCEQIGALDGSAEESKGWTKPR KMSDWCNYLATDILGDLCFGKAFHMLESETNRF
ALGLVEAATTRHLL (0)
CGTMPIVDKLKLDKVLFPGLAAKRARYMAYSKGQLTERTKLGEETDRRDFFYYLLKARDPETGQGFSTPELWSESNLL
(2)
IIAGSDTTSTAMAATLFYLVRCPRALKRVTEEIRSKFNNVEEVCQGAT
LASCTYLRACIDEAMRMSPSVGGITPREV
LPGGITVEGRPIPEGTVVGVPHYAIHHNESYFPSPYEYIPE
RWMAGAVNPLTNEKTTEDEVALAASAFCPFSIGPRGCIGKGLAYVEMTNTLARTIYLYDMRKAIGIVDPA
EGKPNNEWGRHRVTEMQLVDIFTSAKNGPMIEFRKAETASA*
>CYP548A5 Gibberella moniliformis
DR630735 DR651021.1 DR621844.1 cDNA
90% to CYP548A4
also Fusarium verticillioides FVEG_04704
MTFNLTHLLVYLGLLVGGLVLYGFSIVVYRVFFHPLAKYPGPFIAKITDGYQLYHAWKGD
RHLEFWRMHQKYGPVVRFGPNSLCFNSNKALKEIYGFRTNVRKAEFYNAFVHPTANTHNT
RDKEVHARKRRVMSQAFSESAMKEMQRYILGNVRTFCEQIGMLEGSGEETKGWTKPRKMS
DWCNYLAMDILGDLCFGKAFHMLESPTNRFALGLVEAATTRHLLCGTMPIVNKLNL
DKILFPGLAAGRARYMGYSKGQLAERTKLGEETDRRDFFYYLLKARDPETGQGFSTPELW
SESNLLIIAGSDTTSTAMAATLFYLVRCPRALERVTEEIRS
KFNDVEEICQGATLASCTY
LRACIDEAMRLSPSVGGILPREVLSGGITVEGRAIPEGTIIGVPHYTIHHNESYYPSPYE
YVPERWLVGALNPLTGEKTTEDEVALAASAYCPFSIGPRGCIGKGLAYVEMTNTLARTMY
LYDMRKAIGIVDPAEGNPKNEWGRHRPSEMQLVDTFTSAKNGPMIEFRKASHIQA*
>CYP548A5 Fusarium oxysporum
98% to CYP548A5 Gibberella
moniliformis/ F. verticillioides
FOXG_07777
MTFNLTHLLVYLGLLVGGLALYGFGIVVYRVFFHPLAKYPGPFLAKITDGYQLYHAWKGDRQLEFWRMHQKYGPVVRFGP
NSLCFNSNKALKEIYGFRTNVRKAEFYNAFVHPTANTHNTRDKEVHARKRRVMSQAFSESAMKEMQRYILGNVRTFCEQI
GMLEGSGEETKGWTKPRKMSDWCNYLAMDILGDLCFGKAFHMLESPTNRFALELVEAATTRHLLCGTMPIVNKLNLDKIL
FPGLAAGRARYMGYSKGQLAERTKLGEETDRRDFFYYLLKARDPETGQGFSTPELWSESNLLIIAGSDTTSTAMAATLFY
LVRCPRALERVTEEIRSKFNDVEEICQGATLASCTYLRACIDEAMRLSPSVGGILPREVLSGGITVEGRAIPEGTVIGVP
HYTIHHNESYYPSPYEYVPERWLVGALNPLTGEKTTEDEVALAASAFCPFSIGPRGCIGKGLAYVEMTNTLARTMYLYDM
RKAIGIVDPAEGNPKNEWGRHRPGEMQLVDTFTSAKNGPMIEFRKAAHINA*
>CYP548A6 Botryotinia fuckeliana B05.10
AAID01001234.1 cont1.1234, whole genome shotgun
59% to 548A5, 59% to 548A4
41% to AAKD02000022.1 Aspergillus clavatus
MVELPSTSFILSGTLRALVFATTITAVY
(0)
18189
LTTITIYRLTFHPLAKYPGPFLAKITDWYSVYHAWKGDRHLEFYRCHEKY (1)
17991
GPVFRYGPDSLSINSNTALKTIYGHKSNVKKSQFYSVFPPTKDTFNTHSSIDKA 17830
17829
SHARKRRVLSHAFSDNAIKTMEKYILGNVRTFCNNLGQPKASAEKSTGGWSVAQNM 17662
17661
SDWCNYLTFDVMGDLCFGKAFEMLENASNRHVIDLIGNAAHTHLI (0)
17481
TGTYPIIKTIGLSKILFRKIYAQRMKYMAYSRAQAAERTKIGLDTDRKDFFYYLLNARDA 17302
17301
ETGQGFTTPELWGESNLLIIAGSDTTSTALSAAFFYLVHNPDKLEILTKEIMSTFSDVEE 17122
17121
IHSSPTLNSCAYLRAVVDESMRLSPPVGGILPREVLPGGIDIDGLHIPAGYVVGTPHY 16948
16947
TIHHNPAYYPSPFTFLPERWIPSSSPQVTKDSVALAQSAFCPFSIGPRGCIGKGVAYVEL 16768
16767
MTSLARVVFMYEMRIAEGYTVGEGSEEMEVSRRRKEEYQLKDSFTSMKDGPYVEFRARAK* 16585
>CYP548A7 Mgr009 Mycosphaerella graminicola
61% to CYP548A6 Botryotinia fuckeliana yellow
does not agree with JGI model
estExt_fgenesh1_pm.C_chr_130091|Mycgr3
MSLQYLASKLSFNLLALLPVGLAIYTFGLAVYRIWFHPLAKYPGPLLAKITDLHSTYHALNGDRHLEFWRNHEQYGPVYRFGPNSVSFNSNTALKEIYGFKANVQKAEFYQAFWASKDAFSTHSSIDKAVHARKRRVLSQAFSDGAIKSMENHILAHIRQFCANLAGNAESSTHPRYSDSVASTKAFGPTVDITDQSNYLAFDIMGDLCFGKSFNMLTHPDNRFPIDLIASASHRHLICGTYLPIHTYHLDKLLFRKIAAGRARYMQYSKAQAGERMKMGMDVHRKDFFYHLLSAKDPETGRGFAPAELWGESNLLIIAGSDTTSTAIAATIFYLVHNAEKLARLTSEIRAAFDDVEEIRFGQKLSSLPYVRACIDEAMRLSPSVGGLLPREVLTGGIEIDGEQIPAGTVVGVPSYTVQHNEAYFPSPWEFRPERWVAGSEKGVTIDSVARAQSAFIPFSVGPRGCIGKGMAYAEMTTTIARMVWLYDLRLTPG
STLGKGDPRFAYGRQRAAEFQLKDSFTSIKEGPEVQFRARS
>CYP548A8 Podospora anserina
EST CU891099.1
82% to 548A1
MAFGAAHVQLWLGLLAVAGLLYTS
CLVIYRVFFHPLAKYPGPLLAKLT
DAYMLYYAWRGDRHLEFWRMHEKYGKFVRFGPNALSANSNTALKEIYGFRANVRKAEFYD
AFVHPAPNTHNARDRDLHARKRRVLSHAFSDGAIKEVERYILANIRTFCEAIGDYGRAIQ
DNKGWSAPKNMSDWCNWLAMDILGDLCFGKAFHMLDRPDNRYAVDLVGVAAQRHLLCGTM
PIVNKLSLDKILFHKIAAGRAKYMAYSRQQLTERTALGDETRRRDFFYHLLKARDPETG
>CYP548A9 Mycosphaerella fijiensis
72% to CYP548A7 Mycosphaerella graminicola
estExt_Genewise1Plus.C_20402
MSLASTLSATPLSLLTLLPVALAVYFVGIVVYRLYLHPLAKYPGPFLAKITDLHQTYHALKGDRHLEFWRCHEKYGPVVR
FGPNSLSFNSNTALKEIYGFKSNVRKADFYQAFWASKDAFSTHSSIDKSVHARKRRVLSQAFSDAAIKSMENHILAHVRQ
FCQNLGGLTTFGSVPNSESKGYGEPIEISDQANYLTFDIMGDLCFGKAFGMLERPGNRFAIDLIGNAAHRHLICGTYLPI
HEWHLDKFLFRKIAAGRARYMQYSKGQAAERMKMGLDVDRKDFFYHLLKAKDPETGNGFTTPELWGESNLLIIAGSDTTS
TALAATIFYLAHNSSKLQKANEEVRGAFSNVEDINIGPTLGSLQYIRACIDEAMRLSPSVGGLLPRQVLPGGVEIDGQLI
PEGTIVGVPHYSIQHNASYYPEPFVFQPERWIANPGCGVTTESVALAQSAFCPFSIGPRGCIGKGMAYHELTLTLARMLF
LYDMRLAPGSNLGEGRPDLEHGRRRASEFQLKDTFTSMKSGPMVQFRARQ*
>CYP548B1 Fusarium graminearum FG00037.1 AACM01000002
FGcontig1.2_scaffold1
MHRAPNVLTAVDKKAHGMRRRILSQGLSDSSTRAFGNTIKKHIERLCQKI
EGHSDPNTQWSESYDMARWFSYLTFDIMADVVFGQPYNLLGNSEYRYVVD
SIEGSNIRTGVLIQAPEAYTWRLDKRLFPASIRHRNTFVKFISSLVQERL
TTKPLERDDIISHLLTAKDSETGQGFTKNEVAAESSTLIVAGTDTSSTAL
AATLFYLTQYPNMYRRAVAEVRSSFAKSQDVKLGRALNECVFTRACIEES
MRLSPPAASALWRRVQVGGQTVDGHAIQAGCNIGVCIYAIHHNELYYPDP
FVFNPDRWLQNDKQAQSAFSPFSVGPRSCIGKGFAMAELMLAVATILVKF
DIRRAPGDQGCIGQGHLEGEDGRRMVDEYQLHDHV
TAFKQGPVLQFRRRD
>CYP548C1 Aspergillus nidulans AN7881.1 43%
to 548B1 40% to 548A2 53 clan
MLPTYFGTSNFLAAFAVWMGVVVLAFAIFCVRRLYFHPYSKYPGPLLGKL
TNYYAVYHSWKGDQHIDMWRCHEKYGPYVRYGPNELSINTAAGLKEIYSH
GRNFKKSVKYNAMVHQAANTLTTIDKRKHGKKRRLISQAFSDAAFRSYEE
TIQQKIAQLCTALRRRDDDSNEIVPDGNWGPAKNMSHWCDWFTFDVMCSV
IFGVPWSSLTEKTYRNVPHLIEVSNVRVGCLIEAGGSKNMKIDKYLFPAA
IAARNQFVKFVNDIIRQGMAMSAKGSLKGAFALLRDATDPETQEPLSFKE
LCGESATLVVAGTDTTSTALAASIYYLCNHPKVYERAVQEVRSTFQSRAE
IGLGPKVNSCTYLRAVIEESMRLSPSAPGPLWRQADAGGATVDGQYIPQG
LEAGTCVYAIQHHPEIYPQPFKFVPERWLGPEAVPEQYRSDYSPFAGFTP
FSIGPRGCIGKPLAYIELTLTLCHILYAFDMRLPQGVNVNEDAEYQLALH
ITAAKEGPLVEFRPRTVV*
>CYP548C2 Aspergillus niger
gw1.16.377.1|Aspni1
54% to CYP548C1
AM270216.1
MIDSQVLLTFALKGLLLGLIVLSCTVAG
LCIYRLFFHPLAKYPGPWLAKTTKLYAGYHAWRGDLHLDMWRCHEKYGDFVRYGPNSLLVNTADGLHDIYSHGKNFKKAQ
RYAAMVHRAPNTLTVIDKKKHGKKRRVISQGFSDSALKNHEVVILEQIQHLCTQLKAGEGGKPVPADTWSTPKNMGRMTD
YLAFDVMSNIIFDCPWSTLRFPTFRFVPEVIERSNVRVGTLAQSPELSIFRLDKYLFPEAIKARDMFIGFVDVMLTQGIE
AASKTGKGVFALLAKAKDPETGLPLRNRELGGESATLIVAGTDTSSTAMAACFFYLSHNRAAYERAVNEVRSVFSSPEEI
RMGQQMSQCVFLRACIDESMRMSPSAAGSLWREAEEAGATVDGQYIPPGVDVGTCIYSIHHNPAYYPEPFCFQPERWIAD
ECRSVQGDVGRARSAFNPFSIGPRSCIGKSLAYVELHLVLARVLWEFDIRLPEGDLGKTGEGKVGAEYGRHRLDEYQLYD
HLTAAKVGPYLEFCPRK*
>CYP548C3 Uncinocarpus reesii
75% to CYP548C2 A. niger
UREG_04460.1,
MLPAGDFVRYGPNSLLVNTAKGLHDIYSHGKNFKKAQRYGAMVHRAPNTLTVIDKNKHGKKRRIISQGFSDAALKTHEPV
ILKQVQQLKTQLSLDDAGRQVPSGLWTLPKNMARLGDYFTFDVMCNIIFDIPWSTLRDPTYRFVPDVIEKSNVRVGTLAQ
APELTIFRLDKLLFPEAIRARDKFITFIDKVLGEGIKAAGTSGKGVFATLTNAKDPETQQPLRMRELGGESATLIVAGTD
TTSTALAACFFYLSHNRSAYDRAATEVRGVFRSPGDIKMGPSMHQCTFLRACIDESMRMSPSAASSLWREAEEQGATVDG
EYIPAGVDVGTCIYSIHHNPEYYPQPFSFRPERWINDEAHKVKGDVALARSAFNPFSIGPRSCIGKGLAYVELQLTLAHI
FWHFDFRLALGEQGLVGEGKEGAEFGRHRADEFQLEDHLTAAKHGPYIEFRSRA
>CYP548C4 Aspergillus clavatus
82% to CYP548C2 A. niger
ACLA_093770
MLSPQVVSSFALRGLLLGLFALCCTTVGFVVHRLFFHPLAKYPGPWLAKVSNLYAGYHAWKGDLHLDMWKCHEKYGDFVR
YGPNSLLVNTATGLHDIYGHGKNFRKAQRYAAMVHRAPNTLTVIDKKKHGKKRRVISQGFSDAALKNHEVVINEQIRQLL
AQLKTGEGGKAVSVGSWSSPKNMGRFTDYFAFDVMSNIIFGVPWSTLRTPTYRFVPEVIEKSNVRVGVLAQAPEVTFMRL
DKYLFPEAIKARDIFIRFVEEMLNQGIQVAATTGKGVFATLANATDPETGLPLRKRELGGESATLIVAGTDTSSTALAAC
FFYLSHNRSALERATAEVRSTFQSPEDIRMGVEMNQCVFLRACIEESMRMSPSAASSLWREAEEAGATVDGHYIPPGVDA
GTCIYSIHHNPAYYPQPFTFRPERWIASECHTVKGDVSLARSAFNPFSIGPRSCIGKSLAYVELHLALANVLWAFDLRLA
SGDLGKTGEGVENAEYGRHRVNEYQLYDHLTAAKHGPYIEFSPRV*
>CYP548D1 Aspergillus nidulans AN9007.1 46%
to 548A3 53 clan
MLQLLLPRSWPAALLAAGTILSFVWIAYYRFIHPLSRVPGPFLASVTPLV
QLYHGLKGDRHLWIYELHQRYGDHVRLAPNFVSINNVEGLHKIYGHGNKF
RKADFYNGFLAIPGVYNTHNAIDKLVHGRKRRVLSQAFSDTALKGMEDVM
LLHVRQLCSILGRERPTSQSGDKDGATFNMANWFGYLTYDVMGELCFGKS
FDMLIDGAKRRMIHLVDRAAYRHYVCGLWMPLHRWHLDQIFIRRLTNDRW
NFIMESRQEANIRAKERTSLGQDAKKDFFYYLLNARDPETGKGLATQELW
GEANVLMIAGSDTTSTSLSAAIFYLVRNPHALEKLKNEVRSHFSDVEEIV
TGSKLNQLTYLKACIDEAMRLAPAVPGSIPREASDPVVTVDGLVLPEGTG
CGTPPYCIHRRPDYYREPLSYLPDRWIEGSTCKTADAAWTVTREEVDLAR
KAFCPFSIGPRGCIGKSMALMEMRVTLARLMYLFDFELADATGEDENGHF
KMVDHFVVSKTGPNVINIITRSL*
>CYP548D2 Aspergillus fumigatus Af293
GenEMBL
XP_747856.1 also EAL85818.1
70% to 548D1
revised 3/10/2009
MLVQPLLENLSVWGAVQGILSLLGVLTLAYVTYNRFFHPLRSIPGPFLASITPWVQLYHGLKGDRHLWLH
RLHEKYGSHVRAAPNFVSINTDRGLHDIYGHGKRLRKANFYNAFPAIKGVYNTHNAIDKAMHGRKRRVLS
QAFSDQALKSMEDVMLLHVRQLCEILTGGLDGPKGEKSATAVFNLGDWFSYLTYDVMGELCFGKSFDMLI
SSGRRKLIELVDRAANRHYV (0)
CGLWMPLDTWHLDQILIHKLTNDRWNFIMNSRVEANERAKERT
QAGHDAKKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTTSTTMSATIFYLVRNPRAMELLRKE
IRENFSSVEEIVTGPKLNELVYLKACIDEAMRLAPAVPGAPPREVMEGGAMIDGVFLPEGTDCGTPTYSI
HRQPEYYREPEVYIPERWIEGATCQAGSESWTTSKESVELARRAFCPFSIGPRGCIGKSMAFMEMRLTIA
RLMFLFDLELADHKGEDEKGQLALVDHFTSAKYGPNVVVRKRV
>CYP548D2 Neosartorya fischeri
96% to CYP548D2 Aspergillus fumigatus =
ortholog
NFIA_048430
MLVQPLLENLSVWGAVQGILSLFGVLTVAYVTYNRFFHPLRSIPGPFLASITPWVQLYHGLKGDRHLWLHRLHEKYGSHV
RAAPNFVSINTDRGLHDIYGHGKRLRKANFYNAFPAIKGVYNTHNAIDKAMHGRKRRVLSQAFSDQALKSMEDVMLLHVR
QLCGVLTGGLEGKGEKSATAVFNMGDWFSYLTYDVMGELCFGKSFDMLISTGRRKLIELVDRAANRHYV
(0)
CGLWMPLDTWHLDQIFIHKLTNDRWNFIMNSRVEANERAKERTQAGHDAKKDFFYYLLNAKDPETGKGLTTPEL
WGEANVLMIAGSDTTSTTMSATIFYLVRNPRAMELLRKEIRENFSSVEEIVTGPKLNELVYLKACIDEAMRLAPAVPGAP
PREVMEGGAMVDGVFLPEGTDCGTPTYSIHRQPEYYREPEAYIPERWIEGAMCQAGSESWTTSKEAVELARRAFCPFSIG
PRGCIGKSMAFMEMRLTIARLMFLFDFELADHKGEDEKGQLALVDHFTSSKYGPNVIVRKRV*
>CYP548D3 Aspergillus oryzae
GenEMBL
BAE62732.1
81% to
548D2, 45% to 548A2
MLVQEVWKTLSIEGVVVGVSALLGLLSFAYVIYNRFLHPLRKFNGPFLASITPWVQLYHGLKGDRHLWLH
NLHQQYGSHVRVAPNFVSINSAQGLHDIYGHGKKLKKANFYNGFTAIKGVYNTHNVIDKTVHGRKRRVLS
QAFSDQALKSMEDVMLLHVRQLCTALAEQQTEGNKAEAQKTTVQNMGDWFSYLTYDVMGELCFGKSFDML
VSSGRRKMIQLVDRAANRHYVCGLWMPLDTWHLDQIVIHRLTNDRWNFIMNSRVEANKRAQERTQAGHDS
KKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTTSTTLAATIFYLVRNPRAMKLLKKEVREAFT
SVEEIVTGGKLNELVYLKACIDEALRLAPAVPGAIPREVMEGGAVVDGAFLPAGTDCGTPTYSIHRQPQY
YREPEAYLPERWIEGATCVTADDKWESTKDAVETARRAFCPFSIGPRGCIGKGMAFMEMRLTIARLMFLF
DMELADRQGEDEKGHLALVDHFTSAKQGPNVIVRRRDITV
>CYP548D3 Aspergillus flavus
99% to CYP548D3 Aspergillus oryzae
AFL2G_08138
MLVQEVWKTLSIEGVVVGVSALLGLLSFAYVIYNRFLHPLRKFNGPFLASITPWVQLYHGLKGDRHLWLHNLHQQYGSHV
RVAPNFVSINSAQGLHDIYGHGKKLKKANFYNGFTAIKGVYNTHNVIDKTVHGRKRRVLSQAFSDQALKSMEDVMLLHVR
QLCTALAEQQTEGNKAEAQKTTVQNMGDWFSYLTYDVMGELCFGKSFDMLVSSGRRKMIQLVDRAANRHYVCGLWMPLDT
WHLDQIVIHRLTNDRWNFIMNSRVEANKRAQERTQAGHDSKKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTT
STTLAATIFYLVRNPRVMKLLKKEVREAFTSVEEIVTGGKLNELVYLKACIDEALRLAPAVPGAIPREVMEGGAVVDGAF
LPAGTDCGTPTYSIHRQPQYYREPEAYLPERWIEGATCVTADDKWESTKDAVETARRAFCPFSIGPRGCIGKGMAFMEMR
LTIARLMFLFDMELADRQGEDEKGHLALVDHFTSAKQGPNVIVRRRDI*
>CYP548D4 Uncinocarpus reesii
72% to CYP548D3 Aspergillus oryzae
UREG_01325.1
MIVQPLVAHLSLASVGVGFLAVTTLLCFGYVVYNRLFHPLRKYPGPFLATVTPWVQLYHGLKGDRHLWLYALHQKYGPHV
RVAPNFLSINSARGLHDIYGHGKKVKKGDFYNAFPAIKGVYNTHNVIDKHVHGRKRRVLSQAFSDQALKGMEDVMLVNIR
QFCAIMAGDEPSLDSGAAKTERGLVVRNMADWFGYLTYDVMGELCFGKSFGMLIERGKRQVIGLVDRAAYRHYVCGLWMP
LDRWHLDQVFIRSLTNDRWNFIQKSRVEANQRAKERTQAGHEAKKDFFYYLLNAKDPETGRGLSTPELWGESNVLMIAGS
DTTSTSLAATIFYLVRKPTAMAKLQKEVRDNFTDVEEIVTGPKLNELVYLRACIDEAMRLAPAVPGAMPREVLPGGIDVD
GLHLPGGVDIGTPCYTIHRNEQYYREPNSFVPERWIEGAMCETDNKIWTSSKDDVDAARKAFCAFSIGPRGCIGKGMALM
EMRLTLARMMFLFDVEFADRTGEDANGHLHMVDHFTSQKHGPNVIIKKRQSV
>CYP548D5 Coccidioides immitis
87% to 548D4
CIMG_01401.2
MLLQPLVAHLSLLSVGVGFTALTALLTFGYCVYNKFFHPLRKYPGPFLASVTPWVQLFHGLKGDRHLWLYKLHLKYGPHV
RVAPNFLSINSAQGLHDIYGHGKKVKKGDFYNAFPAIKGVYNTHNVIDKHIHGRKRRVLSQAFSDNALKGMEGVMLVNIR
QFCAIMAGDEPSLDAGAQRTQKGFVVRNMADWFGYLTYDVMGELCFGKSFGMLIERGKREVIGLVDRAAYRHYVCGLWMP
LDNWHLDQIFIRKLTNDRWNFIQKSRVEANQRAKERTQAGHEAKKDFFYYLLNAKDPESGRGLSTPELWGESNVLMIAGS
DTTSTSLAATIFYLVRTPDALAKLKKEVRDTFNDVEEIVTGPKLNELVYLRACMDEAMRLCPAVPGAMPREVLPGGIEVD
GLYLPGGIDIGTPCYAIHRKPEYYREPHTYIPERWIEGALCQSENGMWTSSKANVDLARRAFCPFSIGPRGCIGKGMALM
EMRLTLARMMFLFDIELADRVGEDATGHLHMVDHFTSQKNGPNIIIKKRQFA
>CYP548D6 Aspergillus clavatus
82% to CYP548D2, small deletion in lower case
region
ACLA_098250
MFVHTLLANLSVGDVAVRVSFLLSALSIAWVVYQRFISQLCFIPGPFLASITPWVQLYHGLKGDRHLWLHRLHQKYGTHV
RVAPNFVSVNTARGLHDIYGHGKRLRKANFYNAFPAIKGVYNTHNAIDKTMHGRKRRVLSQAFSDHALKSMEDVMLLHVR
QLCaalaggsaagqka
VFNLGDYFSYLTYDVMGELCFGKSFDMLVSSGKRKLIELVDRAANRHYV
(0)
CGLWMPLDTWHLDQI
FIHKLTNDRWNFIMNSRVEANARAKERAQAGREAKKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTTSTTLSA
TLFYLVRDPRALALLQKEVRDAFTSVEEIITGPQLNELVYLKACLDEAMRLAPAVPGAPPREILEGGASVDGVFLPAGTD
CGTPTYSVHRQAEYYPEPETYIPERWIEGATCKTATESWQVSKEAVEVARRAFCPFSIGPRGCIGKSMAFMEMRLTIARL
MFLFDFELADRRGEDEKGQLALVDHFTSAKYGPNVVVRKREM*
>CYP548D7 Aspergillus terreus
84% to 548D3
ATEG_07228.1
MIVQEIWGCISLPRLLLGVSVLLGILTSGYVIYNRFFHPLRRIKGPVLASVTPWVQLYHGLKGDRHLWLHRLHQEYGTHV
RVAPNFVSVNTAQGLHDIYGHGKRLKKANFYNAFPAIKGVYNTHNVIDKTVHGRKRRVLSQAFSDQALKSMEDVILLHVR
QLCAALAGPQADGHHAEEQKGTVQNIGDWFSYLTYDVMGELCFGKSFDMLVSSGRRKMIELVDRAANRHYVCGLWMPLDS
WHLDQIFIHRLTNDRWNFIMKSRVEANERAKERAQAGHDSKKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTT
STTLAATIFYLVRNPAALAKLKKEVREAFSTVEDIVSGAKLNELLYLKACLDEALRLAPAVPGAPPREVMEGGAVVDGVF
LPAGTDCGTPTLSIHRQPQYYREPGAYLPERWIEGATCRAPTGDEWQTTKEDVETARRAFCPFSIGPRGCIGKSMAFMEM
RLTIARLMFLYDLEKADGTGEDEEGHLALVDHFTSAKQGPNVIVRRRAE*
>CYP548D8 Aspergillus niger
fgenesh1_pg.C_scaffold_9000084|Aspni1
82% to CYP548D2
name typo: was labeled CYP584D3
MLAQIGWQALSVTRLGWGLLALLVGL (0)
NQSLIYATYNRFFHPL
RRIPGPLLASITPWVQLYHGLQGDRHLWLCALHEQYGSHVRVAPNFVSVNTAQGLHDIYG
HGKRLKKADFYNAFPAIKGVYNTHNVIDKVMHGRKRRVLSQAFSDHALKSMEDVMLLHVR
QLCAGLARAQQTGVVQDMGRWFSYLTYDVMGELCFGKSFDMLIESSRRRLIELVDRAANRHYV
(0)
CGLWMPLDRWHLDQIFIHRLTNDRWNFIMNSRVEATKRAQE
RTKAGHDAKRDFFYYLLNARDPETGQGLTTPELWGEANVLMIAGSDTTSTTLAATIFYLV
RNPQAMAQLQKEVRENFTSVEEIVTGSKLNELVYLKACLDEALRLAPAVPGAPPREVMEG
GAVVDGVFLPGGTDCGTPTYSIHRQAAYYRQPGAYLPERWIEGAICQTGMEAWQTTREDV
EMARRAFCPFSIGPRGCIGKSMALMEMRLTIARLMFLFDMQLADRRGEDEEGHLALVDHF
TSAKEGPDVIVRARAV
>CYP548E1
Nectria haematococca
fgenesh1_pg.scaffold_5000761
Necha1/scaffold_5:2660663-2662388
76% to AAIM01001130.1
Gibberella moniliformis
44% to 548A4, 41% to 548A3, 36% to 548C1,
35% to 548D1
This gene model seems correct
MPFQLVAERVTPLQLLLLVSSLVLSYVVSVVIYRLYFHPLAKYPGPFWARISAFPAYIHTQRKDRHVWFWQLQQQY
(1)
GPSFRITPNSVLINTPTGLRTIFNNKANVKKAEYYKAYPRNVNAMTTWNTIDKNVHARKRRVMN
NAFSDKALRSCEPFIHDNVDRWCELIIDEIGEGEKWSKSLNMARWADHLIFDILGDLCFGKSFGMKE
PGSELRYVPGLMTDFLEILHP (0)
IAYSPFTALWVWLKPRGLNQLLAAAAPPALKNWQSFVEKCFAERARVEHSAEKSEGGG
RTDFFHYLFKAVDPETGKGYSEDELFGESESLIIAGSDTTAITTAAAFFYLSRSPEVQQKLSDE
ITSTFSSIDEIKSGPTLHSCKYLRAFIEETLRMSPPVPADLSREVQKGGIVVEGEYIPEGIKVSTVSYCM
HHNPEYFPEPFKFQPERWIVDEDDTTGASAERLAVAQSAFMPFSAGPRGCIGKNLAYLEMNLVLAKIIYN
FEIRRDPASNLGGGSPKAIEGRQTVDQYQLYDIFVGIRDGPMVQLAKRTRTA*
>CYP548E2 Gibberella moniliformis
AAIM01001130.1
76% to fgenesh1_pg.scaffold_5000761, 42% to 548A4, 39% to
548A3
also Fusarium verticillioides FVEG_03837
1931 MAIINSVTVFSSSQIFWGIVF
1994
LSFCYVAAVVVYRLYFHPLAKYPGPFWARISAVPAYYYTLRQDRHVWFWQLQEKY (1)2158
2221
GPTFRITPNSVLINTPTGLKTLFNNKANVKKAEYYKTYPRNVHVMTTWNTIDKAMHARKR 2400
2401
RVMNHAFSDKALRSCEPFIHSNIDRWIELLDQEIGEKKWSPSLNMARWADHLIFDTLGE 2577
2578 LCFGKSFGMKEHDSELRHIPTLMTDFMSTIHP (0) 2673
2725 IAYSPFAPLWA
2757
2758
WLKPRGLDFLLAAAAPPAFSKWQAFVEQCFTERVQVENNMRGLWEKGESRKDFFHYLFQA 2937
2938
VDPDTGKGYSKDELFGESESLIIAGSDTSAISLAAAFFYLSRYPHIQQKLAEE 3096
3097
VKSAFSTVDDIKGGPALYSCQYLRAVIDETLRMSPPVPADLSREVQEGGILVDGEY 3264
3265 IPEGMKVSTASYCMHHNPDIYPEPFKFRPERWIVDEKSECGVSPESVSLAESAFMPFSAG
3444
3445
PRGCVGKNLAYLEISLALAKTVYHFEIRRDFSSNLGGGSPNAIEGRRTVDQYQLRDIFVA 3624
3625 IRDGPMVQLAKRS* 3666
>CYP548E2 Fusarium oxysporum (temp 548E4)
94% to CYP548E2 Gibberella moniliformis
FOXG_05969, supercontig_6
MAIINAVAILSSSQIIWGITCLLFCYIAAVVVYRLYFHPLAKYPGPFWARISAVPAYYYTLRQDRHVWFWQLQEKY
(1)
GPAFRITPNSVLINTPTGLKTIFNNKANVKKAEYYKTYPRNVHVMTTWNTIDKTMHARKRRVMNHAFSDKALRSCEPF
IQSNIDRWIELLDQEIGEKKWSPSLNMARWADHLIFDTLGELCFGKSFGMKEHDSELRHIPTLMTDFMSTIHPIAYSPFA
PLWAWLKPRGLDYLLAEAAPPAFSKWQAFVEQCFTERVQAENEMRGLWEKGDGRKDFFHYLFQAVDPDTGKGYSKDELFG
ESESLIIAGSDTSAISLAASFFYLSRYPHVQQKLAREVKSVFSSVDDIKGGPALYSCQYLRAVIDETLRMSPPVPADLSR
EVQEGGILVDGEYIQQGMKVSTASYCMHHNPDIYPEPFRFRPERWIVDEKNEFGVSPESVSLAESAFMPFSAGPRGCVGK
NLAYLEMSLALAKIVYHFEIRRDFSSNLGGGSPDAIEGRHTVDQYQLRDIFVAIRDGPMVQLARRSRTD*
>CYP548E3P Fusarium oxysporum
pseudogene 69% to CYP548E2 Gibberella
moniliformis
FOXG_14148
MTAMITDSSLQMILSGTVFVSTIYGAAIVWYRLYLHPPSKYPGPFWSWISA
(&)
VPGYCYTSR*DWHMKYSKYYEIC (2)
LTFRITPNSVLINTPSGLK
TIYNNKANVKEAVCYKVYHCNVHVTTTWISIDNATHARKRRAMNHAFSDKALRSSEPFIH
SNIDRWIELLKEEIRKRQWSCSLHMARWADRLVFDTLGDLYFGESFGTKERDRELRHIPAIS
(&)
VFTSTIHS (0)
IGYSPCTSLWAWLKPGLDYLLAAAAPPAMSKW
TFVEECFTKRAQIEDEMQARCKSGTESRKDFFQYLVLALDLETGKGCSNEEVFSESGSL
IIAGSDTSAIGLAAAFFYLTRNPHAQEKHAKESRAAFSSVGGIQGGAALHSSQYLRAFIQ
GTMRMSPPVPTDIAPEVQQ (?)
GGIVVGGRYIPEGTKASTVSYCMHHDPDMYPEPFKFRPERI
VDEKDECSDSPESIYLAESAFMTFSAGPRGCVGKNLAYLEMSLTLAKTVYHFKIRRDHSS
NIGGGSSGAINGRRIVDQYQL*
>CYP548E4 Fusarium oxysporum (temp 548E6)
86% to CYP548E2 Gibberella moniliformis
FOXG_14116, FOXG_12421 identical sequences
MAIVDTITAFPSSQIILGTAFLLLGYIAAIVPYRLYFHPLAKYPGPFWARISAFPAYYYTLRQDRHIWFWQLQEKYGPTF
RITPNSVLINTPTGLKTIYDNKANVKKAEYYKVYPRNVHAMTTWNSIDKTIHARKRRVMNHAFSDKALRSCEPFIHSNVD
RWIELLDREIGEKKWSSSLNMARWADHLVFDTLGELCFGKSFGMKEHDSELRHIPVLMTDFMATVHPIAYSPFAPLWAWL
KPRGLDYLLAAAAPPALSKWQMFVEKCFTERAQIENEARGVSKSGTESRKDFFHYLFHAVDPDTRKGYSNDELFGESESL
IIAGSDTSAISLAAAFFYLTRYPHAQEKLAKEVKSAFSSVDDIKGGPALYSCQYLRAFIDETMRMSPPVPADLAREVQEG
GIVVDGQYISEGMKISTASYCMHHNPDIYPEPFKFRPERWIVDEKDDCGVSPESVSLAKSAFMPFSAGPRGCVGKNLAYL
EMSLALAKIVYNFEIRLDHSSNL
GGGSPDAIKGRRTVDQYQLRDIFVAIRDGPVVQLAKRTHMD*
>CYP548E5 Fusarium oxysporum (temp 548E7)
frameshift at C-term
76% to CYP548E1 Nectria haematococca
FOXG_07116
MFIRYTVKDISPSQALALVAALALSWIIATIVYRLYFHPLSKYPGPFWARISAFPAYYRTKKQNRHIWFWQLQQKYGSTF
RITPNTVLINTPTGLKAIFNNKANVKKAEYYKAYPRNVHAMTTWNTIDKTIHARKRRVMNNAFSDKAMRSCEPFIQENID
RWFELINEEIGKKQWSDSLNMARWSDHLVFDILGDLYFGKSFGMKEHDSDLRHIPRLMTDFMALLHPIAYSPFTALWVWL
KPRGLDQLLAVAAPPALSRWQNFVEKCFAERAKVEDDARKLNKPEADSRKDFFHYLLQAVDPVTGKGYTKDELFGESESL
IIAGSDTTATSTAAAFFYLSRSPQVQEKLVKEITSAFSSADDIKGGTTLYSCQYLRAFIDETLRMSPPVPADLAREVDKG
GIVVDGKYIPEGINVSCASYCLHHNPEFYPEPFKFYPERWIVDEKNESGVSAESVALAQSAFMPFSTGPRGCIGKNLAYL
EMSLVLARIVYNYEIRPDITSNL &
GGGSLNAVEGRRTSDQYQLHDIFVGIRDGPMVQLARRTRSA*
>CYP548E6 Mycosphaerella fijiensis
56% to CYP548E1 Nectria haematococca
e_gw1.5.510.1
MAWLFDSVLPSEGLVYPNILALAVAIITIAVSTTAIYRLYLHPLAKFPGPFWARLTTIPSYWHTHKGDRHVWLWRLQQQY
GTTFRYRPDAVLINTPTGYRTIFGPKGNVRKSDYYRIWPSDSSVSNAWNATEISIHGPKRRVLNHAFSEKALRSAEPFIQ
SNTDRWCELISNRIPKSNEWSPSLNMTKEINHLIFDILGDLCFGKSFEMKEPASKLRYVPELLADFLVLMHPIGFSPIAD
FWVWLKPRGLDALLAYTAPAALAGWENFVAKCLQDRTKVEEEVREGKLEARQDFFYYLFDAKDPETGKGYTRQELYNECE
LLIIAGSDTTSIVTSAMMFYMSRNLEIQAKLAKEVCGAFKSAGEIQSGLKMQSCRYLRAFIQEALRMCPPVPADLARQVR
AGGTTVEGHYFPEGTKLSTALYCLSYNEDVFPEPFSFKPERWILGESGGCATEESLALAESGFCSFSTGSRGCIGRNLAW
MEMMIVMAKVVWNFEIRQDEGNPLGAGDEKGPEGRRCVDQYQVKDAFVAMRDGPMIQFRRRTHE*
>CYP548F1 Aspergillus oryzae RIB40
AP007157.1d genomic DNA, SC023
complement(join(472501..473171,473240..473483,
473556..474019,474079..474229,475214..475264))
EST AB227122
42% to 548A4, 41% to 548A1
MQVGGLRSRVSVLVAIQLVSLIVYRIYFHPLSKIPGPLLPKITD
WYPAWCVWRGSSHTALWEGHRRY GSIGRCGPNSVSVCSQTGLMEIYSTKANVCKDESY
VVMSVGSHAPNTFSFIDKKTHAFRRKILFQAFTDNALNGVQDQILSHISEFCAMLNPP
PSNGAGQSSVWGPSVDIAPLCDYLAFDVISDLSYGRSFGMLKSDRYRYVPKLTRRLAR
RNATCMTQSKLWRYKLDRLFFAGFLKALRDFGLWIRHQGKERIRLGNNGPRKDCFHYL
LSGSDPKTGQGLTERELRVELLLLIVAG SDTVATSLSAVLFNLAHNQQALQKATAEIR
SCFEREEDIRLGTRLKSCSYLHACISESLRISPAVSNMPPRRVLPGGITVDGYYIPEG
TIIGTPIYALHHNEEYFPRPFKYEPERWLENEANGENPSTDDGLKRARAAFCPFSIGP
RSCVAKNLAWAELTLTLARVLFSYDVRLPPDHCEVEPDCCSSVPRDQSPEYKLRTWIV
SAREGPSLQFRPRNVKVP
>CYP548F1 Aspergillus flavus
100% to CYP548F1 Aspergillus oryzae
AFL2G_04070 revised
MQVGGLRSRVSVLVAIQ (0)
LVSLIVYRIYFHPLSKIPGPLLPKITDWYPAWCVWRGSSHTALWEGHRRY
(1)
GSIGRCGPNSVSVCSQTGLMEIYSTKANVCKDESY
VVMSVGSHAPNTFSFIDKKTHAFRRKILFQAFTDNALNGVQDQILSHISEFCAMLNPP
PSNGAGQSSVWGPSVDIAPLCDYLAFDVISDLSYGRSFGMLKSDRYRYVPKLTRRLAR
RNATCMTQSKLWRYKLDRLFFAGFLKALRDFGLWIRHQGKERIRLGNNGPRKDCFHYL
LSGSDPKTGQGLTERELRVELLLLIVAGSDTVATSLSAVLFNLAHNQQALQKATAEIR
SCFEREEDIRLGTRLKSCSYLHACISESLRISPAVSNMPPRRVLPGGITVDGYYIPEG
TIIGTPIYALHHNEEYFPRPFKYEPERWLENEANGENPSTDDGLKRARAAFCPFSIGP
RSCVAKNLAWAELTLTLARVLFSYDVRLPPDHCEVEPDCCSSVPRDQSPEYKLRTWIV
SAREGPSLQFRPRNVKVP
>CYP548G1 Aspergillus clavatus NRRL 1
AAKD02000022.1 ctg02_1099423829560, whole genome
65% to 548G2P 39% to 548A3, 41% to 548A2, 42% to 548A4,
40% to 548A5
in the CYP53 clan part A
ACLA_043850 GENE MODEL REVISED AT N-TERM
MILAVHNLLDSLTVYSWRLLTTGASLGLFFL (0)
IGLSVYRLFFHPYAKYPGPLLAKLTSWYAVYHSYVGDLHTDIWRCHQKY (1)
GDVVRYGPNRIVIDSEYGLK (1)
AIYGHGANVHKSKGYERVSFIPKVHATL
CTLDDARHKFYRRLMNQGLSDTNIRRMDNKLKSIASLFASSLGEPTDRFHKSEDPAGDGWSVPKNMSHW
(1)
CDYFTFDVMSELVFSKSYNLLTDSTNHWIIEGVLGQ
MQRFGFLLQLPELETLKLNHLFFPEARRRAIRFSAKAREIMQERQSRQKEELNDILGNLL
AAKDPETGEGLPNAQLWVDTNLLIIAG (1)
SDTSSTGMAALFFYLSRNPTAYDRVIKEVRAVFNNPEEVAQGPLLNSCIYL
RACISEAIRLCPAVSGALWREVLDGGLSIPEMNIHIPA
GCEVGTGIWSLNHNEKYFPDPF
AFRPERWIAEESGDEAVTLAKSALASFSVGPRNCVGKGLAIIEISLAIAAVISQYDFRKA
ETRCTEVGEGKGEFKGQFQTSWAFTSLKDGPYIQFRKYMPGSN* 306652
>CYP548G2P old name = CYP668A1 Aspergillus nidulans
AN1300.2 AACD01000017
poor match 53 clan similar to 548A3
pseudogene of CYP548 family
45% to 548A1, 40% to 548A3, 41% to 548A2
65% to AAKD02000022.1 Aspergillus clavatus
344602
FFYLSRNPSAYDR
VTKEVRNAFLTPDSVCQGPKLSSCVYLRACIQEVLRLAPAVSGALW
REVLPGGLRI
344397
IPA
344356 GTGIWTINHN
ERYYPQPFSFRPERWIPEEFGEEAVQLATAAFTTFSIRPWNCVGKALAMI
EMTLAMAAVISHFDFRRADGAAGGLGEGKGSFDGQFQTFWAFTGFKDGPM
IQFRPRKY* 344006
>CYP548G3 Fusarium oxysporum
58% to CYP548G1
FOXG_16410 revised
MALSTNSPVPSWTLFASSAGLGIL (0)
LLYICIYRVFFHPYAKYPGPFLAKLTSWYSVYHTYYGDLHLDIWECHQKY
(1)
GNYVRYAPNRVLINTPEGLK (1)
AIYNHPKNTQKSKAYRK
MSLVPGVHSSFSTIDNQAHAKLKSLISQGLSNSHIRAYDPELRQSALLFATRLGEKIDRFEPDQSDVGEDGWTAPKNLAS
WSNYFTFDVMSHLVFGTSYNLLTNSENHWVIDGVLGQMRRMSFLTMLPELEDMRFDLLLFSNARRMAYRFAVKSREIMEA
RKIREKAMEGQETKVDLFSKLLAAKDPETGEGLPDKQLWAESNVMIIAGSDTSSTAIAATLFYLSRNPSAYARVTKEVRS
AIITPEDICQGPKLLSCTYLRACIFESIRLSPPAGGAMWREVMPGGMHIAGNDVDIHVPGGCEISTGIYAVHHNEEYYPD
PFEFRPERWLADEVGDETVAKAHAAFDAFSQGPRGCPGRSLALIEISFAVAAVIMSYDFRKVESSLGEVGEGNGKFAGQY
QTSWVFSSFKDGPYLQFKRIK*
>CYP548H1 Aspergillus oryzae
GenEMBL
AP007171.1 BAE64607.1
45% to
548C1, 50% to 548B1
14 P450
genes and 2 pseudogenes on this contig
MQAVALLRHVPLFAYVTAVPVALLAYVLAICIYRIWFHPLAKYPGPLLAKVTNLYGGYYAWKGDLHIDMM
RCHEKYGNYVRYAPNRVLFNTNTGLKEIYAYSKSFQKSAAYGAMVHRAPNTLTLIDKKQHGRKRRIIGQG
FGDAALRGFEGTIMSLVRKFCDELAKDISGRKAGEWSTPQNMGKWSNYLTFDIMSGIIFGESFDLIGSPK
NREIVKCIEDSNVRTGVLSQAGELSTRRLDRWLFPQAIQGRNAFIRFVNILLKKRMSAKPLKRHDAFSFL
LDAVDPETQQGFTPAEIGAESTTMIVAGSDTSSTAIASTFFYLCRNREWYEKAKEEVRAAFPGPDDVALG
PALNNCVILRACIDESLRMSPPASSSLWREVLDDGVIIDGQVVPRGYDVGTCIYAIQHNPDYYPEPFEYR
PDRWLDPVPEKVQLARSAFSPFSIGPRSCLGKGLAWTELMLTMAYMLSKYEFRSAPGEDEKVGGGHVDMG
AGRQREGEYQLRDHVTAAKDGPIVQVSFR
>CYP548H2 Aspergillus niger
gw1.11.642.1|Aspni1
56% to CYP548H1
VYAIYHLFFHPLAHFPGPFWAKFTCLYSGYHAWKGDLHIDMQRCHEKYGDFVRYAPNQLLINTSIGLHDIYGFGRNTQKS
KLYSAMVHRAPNTLTLIDKKAHGRKRRIISQGLSDAALRRYQPAILKHINELCGALVGSKPSEWSVPRNVAHYFNFLTFD
IMSDVLFGEHYNMVTSEEHRYVVKAIEDSNVRTSVLAQAPLLAFRRWDRKIFAESILARNKFIQFVNTLLQRRFKAAKSA
RQDVFTFLLDAKDPETQQSLSLAEIGAETTTLVVAGSDTSSTAFSSCLFYLSHNKDWYNRVATEVRNTFSSPDEITLGPR
LSSCIYLRACIDESLRMSPPAGSALWREVGPGGATFDGHFIPAGCDVGTGIYAIHHNENYYPEAFNFRPERWILAGAEGD
TEAVGMADRDSLAKAQGAFNPFSIGPRGCIGKGLALAELTLGIATMLWRYDFALGEGKGMALGAGRKGLGPGRERENEYQ
LYDHITASKEGPMVCFRER
>CYP548J1 Gibberella moniliformis 7600
chromosome 11 cont3.130
26kb from a PKS
AAIM02000130 revised
Also Fusarium verticillioides, FVEG_10545
45% to CYP548H1, new subfamily in CYP548
CYP5115 may belong here too
41% to DR630735 DR651021.1 DR621844.1
Gibberella moniliformis cDNA
44% to XM_001273103.1 Aspergillus clavatus
43% to XM_001402423.1 Aspergillus niger
MPMSHMKTHWLPYAIRISRSITPPPLLIILLLAALSP (0)
VIGYVVYYAFFHPLAKYPGPFWGKFTGLRAAYHAWIGDVHIDMWKCHEKY
GPYVRYSPNYLLMNTTQAYK
57293
DVYGHNKNVRKSLAYLAMVHKTPSTFTLMDRHEHAWKKRILSQKLSDSAIRSFEPKITGM 57114
57113 IDRFCQYVCPPASTGKENTVSKPFNMSEMC (1) 57024
56947
DYLFFDLVTSIVFGENFDLIRSPWYRHIPPALARSNERISVIVQWPYVVWRRMDKVLFRN 56768
56767
SVAGRKDFLRFAHNLVTERVQRGSGDDVLSGLLDAADPTTGNKLTQDEIVAESILML 56597
56596 VA ()
GSDTSSTLLASLFFYLTRNPDKKDRLTREVRSKFSTREEICLG 56417
56416
PALNSCRFLYACIMECLRLTPPVAAAPFREVLKGGMIVDGHYVPEGTNVGTGLFSIQHNQ 56237
56236
EYFYSPFEFIPERWLSEGKNAGPHNPDAHVPFSIGPRVCLGRALAHAELSL 56084
56083 AMAIICWKMDFNVVESMKDIGAGNENAEYGRHRPGEFQLYDHITCARNGPMVEFRERSF*
55904
>CYP548J1 ortholog Fusarium oxysporum
97% to CYP548J1 Gibberella moniliformis
FOXG_11965
MPMSHMKTHWLPYAIRISRSITPPPLLIILLLAALSP (0)
VIGYVVYYAFFHPLAKYPGPFWGKFTGLRAAYHAWIGDVHIDMWKCHEKY
(1)
GPYVRYSPNYLLMNTSQAYK (1)
DVYGHNKNVRKSLAYLA
MVHKTPSTFTLMDRHEHAWKKRILSQKLSDSAIRSFEPKITGMIDRFCEYVCPVSAGKENTVSKPFNMSEM
(1)
CDYLFFDLV
TSIVFGENFDLIRSPWYRHIPPALARSNERISVIVQWPYVVWRRMDKVLFRNSVAGRKDFLRFAHNLVTERVQRGSGDDV
LSGLLDAADPTTGNKLTQDEIVAESILMLVAGSDTSSTLLASLFFYLTRNPDKKDRLTREVRSKFSTREEICLGPALNSC
RFLYACIMECLRLTPPVAAAPFREVLKGGMIVDGHYVPEGTNVGTGIFSLQHNQEYFHNPFEFMPERWLSEGKHAGLHNP
DAHVPFSIGPRVCLGRALAHAELSLAMAIICWKMDFNVVESMKDIGAGNENAEYGRHRPGEFQLYDHITCARNGPMVEFRERSF*
>CYP548K1 old name = CYP5115A1 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000308.1
47% to
548H1, 39% to 5114A1
37% to
5114A1, 39% to 548A3, 37% to 548G1, 38% to 548A6, 34% to 548D2
MNYLSVLVVAVAVTLLY (0)
43655
LIARVIYLAFFHPLAKYPGPFLSKFTCARASYYAWRGDIHIDIWRCHEKYGDYMRYGPNQL 43473
43472
YVNTPKGLRDVYGPTTSNKFLKSSHYEVMTHQAANTFTHRGGKEHLRRRRIMAQAVSTKA 43293
43292
QLEYEPRLVGHIQKFCNAVFKGEPMNMAKWCNYLAFDSMTDVVFGAQYNL 43143
43142
LGDEKFRYVPEMIEKSNVRISSLVQFPGLTWLRLDKHLFQEAIYARNRFLKFVFRLLSDR 42963
42962
RALSHGTARGVFENPSISLDVYSRLQDARDPVTGEGFGHDEIASESTTLIVAGSDTSACA 42783
42782
TASILFYLANNPHAYARVAEEVRAVRSSRPGHLAAADLAGCKYLRACIDEALRMSPPVGT 42603
42602
GLMREVAAPGGLVVDGHVVPMGCEVGVGTYAIHHSTRAFEDPFVYRPERWLAPDESAHAR 42423
42422
ACFVPFSAGIRSCLGKGLAYTEVTLTIGHLLWLGDFKLVADAELAAVGRGSRK 42264
42263
LGVDGRHREGEYQLYDHIAGQKNGPWLQFTRRAEVQ* 42153
>CYP548L1 Aspergillus niger
gw1.12.692.1|Aspni1
51% to CYP548K1
VIYLLFLHPLAKFPGPIFASLTHGYGAYHSWKGDAHLDMWRLHEKHGDFVRYMPNSVFIRNADALHAIYSTKAYASVVKS
PHYEVLQAGSVGSTFSLRGGHEHLRRRRIVSTALSEKAQRGMDPRIAVHVRKFCEAVLPARQGELGEPMNMAEWCGYLTF
DLMSDLVFSASYNLLGREKFRYMPEVIDKSNVRMSVLAYMPILAAWRAVDGIFFRDALIARNRFLRFVVRAVRERANRAL
GKWAPDALDPCKPRDDIYSALATAKDPDTGEGFKPSEMVSESTTLVVAGSDTTSTAIAATLFYLADNRFAYEKAAQEVRT
VFAGKSLGSEEALSGPELSQCTYLRACIDEALRMSPPNGAALTREVLPGGLTVGDIHIPGGVTVAVPLYAIHHDERYYVD
PFTYRPERWLEDDGTGSIKRARLVFNPFSLGMRGCLGRSLAYHELMTTVATVLYLSDFEFAEGPMSKVGRGVPGAVYGRH
RENEYQLREHITGQKDGPWLRFSRRE
>CYP548M1 Aspergillus niger
e_gw1.8.742.1|Aspni1
67% to fgenesh1_pg.C_scaffold_4000313, 42% to CYP548A2
MDLLGCVVIAVAGYIIYQVWFHPLSSYPGPFVAKLTNLYSVVHAIRGDRHEDLYHLHQRYGPVVRVGPRRVSILDAKALE
PIYGFHANVQKAKSYNIFYGVSIFNAIDRTVHARKRRVMSHAFSSQALRGMEPHILSAIRDWCAALGDQHPDKQVLSACS
RPGSWSRPKNMVHWSACVVFDALGEICFGKTFNTSFSDANHFFFPLMALNLRIMNICGQMPILCSLGLERYLRRGTVANR
QRQIDFSRQQLQTRLAAESTQRRDIIFYLQQARDPKTNEGYSEAELMSEVMTLLGAGNDTTNTTLTAIFYYLAHNPAILA
RLSAEIRAVFPTLEAIVAGPDLSQMAYLHACIDETMRVCPPVPTDLPREVLPGGLRVGEWYFPAGTVVAVPTYALHHSED
HFYRAFVYDPSRWLLCGSKGTEQGEGVSAEVLSRQRQAFAPFSMGPRACIGRNVAILELELTISRALWLYDIRLAPGTEQ
LGVGYQGEYKIKDHFAVGKEGPVLQFRMRQK*
>CYP548M2 Aspergillus niger
fgenesh1_pg.C_scaffold_4000313|Aspni1
67% to CYP548M1, 44% to CYP548A1
MLDNFIQLVLGTISLGKLLFAILSAAGLSYVVYQVQFHPLAAYPGPFLAKLTNLYSVVHAMRGDRHEDLYKLHQRHGRIV
RIGPNRVTILDARALEPIYGHQANVQKSQWYHNFYSVSIFNAIDRNVHARKRRVMSQAFSDHALRGMEPHILSAIRDWCL
ALGDEHSNQSQGKQSQASSSSSSSSGGGWSRPKDMVHWSACLIFDALGEICFGKTFNTTRSDENTFFFRLMAVNVRILNI
CGQMPLLRRIGFDQYLRMGTAGDRERQIAFSRQQLSTRLAANPTERRDIIYYLQQARDPETGEGYSTQELISESTLLLGA
GAETANTALASTWFFLAHHPAIRQRLTNLIRAHFASLESIVSGPALSSGKMGYLRACIEESMRLCPPVPMDLPREVLPGG
LQVLEWEFPAGTIVGVPTYSLHHSPEHFDRPYEYDPNRWMLRGTEAADEGVGVSPEVMARQRAAFVPFSLGPRACIGRNV
AMLELEVSVARVLWLYDLRLAPGMEHLGVGREGEYKMKDNFIVGKEGPILEFRKRA*
>CYP548N1 Mgr037 Mycosphaerella graminicola
48% to 548A6 N-term from JGI model e_gw1.10.623.1|Mycgr3
MDQSSSVPDQIFLRPHQENIYTLLNSSHYTWTILALTTLLTALT
SYTIYQLHFHPLASHPGPLLGRLTQLYDLYHAYIGDKHILFHHLHQKYGPIVRFSPNSLSINDPAALKTIYSHGANVQKS
VFYKCFRAAPQAISTLLATEKQHHARKRRIMGQAFSEAALRGFEAFVVGHVEDLVGRIGEVVGSSSSSSRGQEGEKWSAP
LDMANWCNWLVFDIMGDLVFGRSFGTLGEKPENRRGIFLLGRAARRNYTIAAMPMLLYTGLEKVLPILRGLYLDRCQYLA
FGKKQVMERTKE GAGSAEPARRDIFSFLLHAKDPEEGEGMPMPELWMEGNTLIVAGSDTTSTTLAAALHYLLHNPHTLHR
LESEILSTFSSPSEIAMGPKLQSCTYLRAVLDETLRMTPAVGGLLPREVLPDGLSIPSLDLHLPAGVDVGVPIYAIHHHK
DYVVDPFVFDPERWIREDHAQDREKLMSVFNPFSIGHRGCLGKPLVYMELGIAVARLVWEFEMRLSEVQRVSGFVERDVR
RGRRVEGEYHLLDWFMSRNEGPRVEFRRRE
>CYP548N2 Mycosphaerella fijiensis
73% to CYP548N1 Mycosphaerella
graminicola
estExt_Genewise1.C_160063
MELRPHLHIHTCASSYQCISAVALCGA
MLAVLTAYVIYQLHFHPLAKYPGPLLGKLTQWYDVYHAYVGDKHILFYHLHQKYGTVVRFSPNSLSINDPAALKVIYAHG
ANVQKSVFYKCFRAAPTAISTLLATEKGHHARKRRIMGQAFSDSALKGFEEYVVALTDNLVTRLQAAITRSDGEKTRWSA
PLDMAAWCNWLVFDIMGELVFGRSFGTLGEKPENRRGIFLLGRAARRNYVVAAMPALLYTGLEKWLPLLRGLFLDRCQYL
AFGKKQVMERTKEQSFGQPGSPSRDTGRRDIFSFLMTAKDPETGEGMPMPELWMEGNTLIVAGSDTTSTTLSAVLYYLLH
NPHTLQKLQREILTTFESSSEIRMGPKLQSCTYLRACIDETMRMTPAVGGLLPREVLPGGLEIPSLNLALPAGIDVGVPI
YAIHHHQDYIASPFLFDPSRWLPSDGKPHAQSKEALLAVYNPFSIGHRACLGKPLVYMELMISIAKIVWEFEMRLAEEQF
VSREIRKEVRSGKRQRYEYQLQDWFMSRNEGPWVEFKVREGAS*
>CYP548P1 Yarrowia lipolytica
45% to CYP548A1 N. crassa
CAG83449.1
MSLLETIVQFVTLVAAFVGGFLALAAFYRLTLHPLAQYPGPLLCKLSSIPDVYHAWKGDRHLHYYRLHRKYGSVVRYAPN
KVSFDTGAALKHIYSGNKKEFIKSDFYEGFPAVKGFPSVHSAIIKSEHAKKKRVMSHAFSEQALASAQPYIMDKIVQLCD
LLGDNTRDTVVTPSGKPAKMISRLTSYFSFDVMGELCFGKGFDMLTSADNRFALRMTSNAAHRHLVYGCFRLLDKLPFIG
SYFFGHIVEDRKKFVEYSRAVASKRMALGDEGHRKDLFHYLMHATDPETGKGFERNELLSESNLLIVAGSDTTATSLAGC
LHYLGLHPDVRKELTRQVRAQFYSVDEIHSGSTLTKGIPLLRACIDESMRLSPPVPGVLPRTALEDVVIDGCKIPKGCDV
GVSTWSMHRNPKHFVKPLEYDPYRWLRGGQVDDSSKYSDVAQDIDEKAALNETANARAGYAPFSIGTRSCIGRALAYSEL
DCAVARICFMYDFEVCLEGKLGSGVFGYGYDDSDEFVAGRGKGGKINEWDVKKRDGEEIGTFRLWDHFAGEKEGSMMVFA
HAKKE
>CYP548Q1 Coccidioides immitis
43% to CYP548H2
CIMG_05501.2 gc boundary at QAHQ?
MLSGRNR (1)
AVIIYELWLHPLAKYPGPLIAKFTHAHAGYHGWKGDIAHDIWRCHQKYGDYVRYAPNALLINTAQAHQ
(1)
DIYGFGGKVVKAANYSILAQRAPSILTLRDAKEHRRRRHRVALALGEDNVRFYEPQMLNHIRTFCA
KMVEGVKNVDGWSALRNMAPWCNYLLFDIMMSMVFSSDSKLLTHPKYRHIPNAIHQSSVLQGVLVQDKTLAILGLHKYLF
KTAVRERVKFVHFIRTVLGIRLNKSASYTADSDPCHDVFAYLRNNLSSADLAQLSPKELSAECATLIIA
(1)
GSDTSTMGLAGALFYLSRYRSA
YDRLVQEIREKFNDASDIRLGKTLYSCSYLKSCIQETLRISPPVGTALWREVEPENGATIDGAVIPKGTHVGVGIYSIHH
KPNHFSDPFTFRPE RWLSEARPADLVNHE
TRAYGPFSIGPRSCVGKGIAMQELMLSLA
HIFWSLDFEALAPDGNRVTIEGSVLHPSPGWTEFPMKEYIIAVGDGPMLRFRRRAVE
>CYP548R1 Histoplasma capsulatum G217B
teleomorph: Ajellomyces capsulatus
45% to CYP548A2
HCB01307.1
MDTLFSLASQDGVNGLLAVFAVCSIVGIYRLTLHPLAKYPGPFSCKLSDWATLFNASSGDRHLREWKAHQKYGPIVRTGP
NTVSINSVAGFKAIHGSRLSNVRKSDWYLTVEGAVGTPMTQTILDRQTHAFHRRVLDVALSETALKSVEHMIIENVHSWC
AHLAEGISKPGDWSSPKNMADWATYLSYDIMGDLTFGKKFHCMDSDEHRFVPLLMLNATKMVYFIGLSPLAPLLRPFLGS
PIMNVVGGQMARDHLKYKRYSASQMKQRIEAETDDSKPTRKDLAHYLLNARDSQTGKGLTTEELYSESSLLIAAGSDTTS
IAISAIMFHLSHHPEILGKLTSIIRSTFSSLDEIQAKALNNLPYLRACLDEGMRLSPVVPSHLPRQVLPGGLTIEKHHFP
AGIVVNTPPYTINHNEEYYPDPFSYRPERWIVDPYALDGDIGSESQVAIARSAFTTFGLGPRGCAGKRLAYLELGHAFTR
LLFSYDMRVSPANETLGAGNPNHEHEGRRRPDEYQFEDYFLVTRDGPLLEFRPRCE
>CYP548S1 Aspergillus clavatus
45% to CYP548A2 Magnaporthe grisea
ACLA_062280
MALSPSAIAGATALFGVVYLVVVSVYRLYFHPLARYPGPWLAKVTSLYAAYLSYTGEIHLEMWRAHEKYGDVVRFGPNRL
LFRTSTALKDIYGFGQNIRKAAAYHQFPTKFAYSTHNAVDKEMHRRKRKLVNQAFSKNALKIWETSQLQQIRIMCNELIQ
PSSTPSLSEKQGWSSPKKMSDYALYLMSDIVSEAVFGTSFRTLTEQTNRHVLHLVHKSYEWIGIIFQSPTISKLGLDGYL
IPQLARARQALRDDFRVLMRDRINSQTEKRDIFSIYSEYTDEKTGESFPLSEITSEALLLFGAGPDATSTSLTAAFFYLA
RNKAAYDKVVAEVLSTFTDVEEIVGGPKLNSCHYLHACIDEALRMNPVNGGALWREVVSGGATIDGHSIPAGADVGVAIY
SIHHQADYYPDPFTYRPERWIASPETGVTPAAVDAARKAWSPFSIGPRGCVGKSLATTLLHISLARVLFLYEMQLPKDER
LARVGEGKPGLPFPRNLTSELQSKGTFSSIVHGPMLEFKRR*
>CYP548T1 Neosartorya fischeri
43% to 548E1
NFIA_095340
Note: this seq does not have an ortholog in A.
fumigatus
MFVAAGLGMMVAHWPAVIIGFAICYLLGSAIYNLYFSPLAKYPGPLFAKVSALPDFYWSLTGDRHMWIARNHEIYGDVVR
FRPDGLLFRTPQAHRDIFNHKANVKRAKFYDMLTRNKHDTSTITGTDPTLHAQKRRVLNTVFSEKSLRSMEPFLVKHVTR
WCELLIDGDGTDWSTPRKMSEACDYLVLDVLCDLCFGQSVDTKEPGENEYHKIPHAIGSFLDILYPLGHSPWLDLIVWLK
PRGLDWVFGALTPPHIQFLYEFVKQSLAQRLKTEKETPSTGQEGRGDMLHYLIHAKDPATGRVGYTPEALEAEALMLTIA
GSDTTSVIMAGFFFYIVRTPRAYRKLVNEIRSTFTNIDEIRAGPKLTSCQYLRACVDEAMRIMPPGPSEMPRIVLPGGII
VDGDHIPEGTTVGVASWSSYRNEEYFPDPNVYRPERWIVDEEAGVTAEDVARARSSCFPFAAGTTGCAGKNFALLELYMT
IASTLWQYDARLLPGDMTGAGSKAQGWGKRNPKIFHVKDKYISVRDGPMVQFKKRVA*
>CYP548T1 Aspergillus terreus NIH2624
AAJN01000173.1
92% to CYP548T1 Neosartorya fischeri = ortholog
ATEG_06914.1
21150
MYIAAVLTMMRPHWAAVIIGLAVCY (0)
FIGSAIYNLYFSPLAKYPG 21329
21330
PFLSKISALPDFYWSLTGDRHMWIARNHEIYGDVVRFRPDGLLFRTPQAHRDIFNAKANV 21509
21510
KRAKFYDMMTRNKHDTSTITGTDPALHAQKRRILNTVFSEKSLRSMEPFLVKHVARWCEL 21689
21690
LIDGDGTDWSTPRKMSEACDYLVLDVLCDLCFGQSVHTKEPGENEYRNIPHAIGSFLQVLYP (0) 21875
LGHSPWLDLIVWLKPRGLDWVFGALTPPHIQFLYDFVKQ 22049
22050
SLAQRLTAEQETPSSGHEGRGDMLHYLIHAKDPATGRVGYTPEALEAEALMLTIAGSDTT 22229
22230
SVIMAGFFFYIVRTPRAYRKLVHEIRSTFASVDEIRGGPKLTSCQYLRACVDEAMRIMPP 22409
22410
GPSEMPRIVLPGGIIVDGDHIPEGTTVGVASWSFYRNEEYFPDPNVYRPERWIVDEHAGV 22589
22590
TAEDVARARSSCLPFAAGTTGCAGKNFALLELYMTIASTLWQYDARLLPGDPTGAGSKAQ 22769
22770
GWGKRNRNIYHVKDKYISVRDGPMVQFKKRVA*
22868
>CYP548U1 Aspergillus terreus
41% to CYP548A6 Botryotinia fuckeliana
ATEG_03468.1 N-term exon not identified
FVTVVVYRLFFHPLSKYPGPFFWRISILPSLYYAWTGDRHLVVDKLHKKY (1)
GKVLRMEPNLISICTPNAIK (1)
TMYGPGTKFEKAMFYTRGPKEKQLLV (0)
NLASTTDKAVHARKRRIISHALSEASIRSYEVTILDKIQLFCKQLSDASTFGGPY
KNMSRWFSYLTYDIMGQLTFSQSYDMLTKDDHHFIQPLIDSYQHSQ (0)
LGTEPKLDQWGLAPLLLLRIMAENKKFRRYVDDQ
VNHRIALEKAGQGPPDIFKLLLEHKDKETGESMGFKELSDEAVVLIIAG
SDTTGTALSGLYFYLARYPECYAKLSHEIRSTFTQVDEIVGGPKLQACSYMRACVEEALR
MSPGVPGFLTREAPSGASIDGYYFAPNVQVAIPTWTMHRTPEVYPDPQVFKPERWM
VESEAELQRLRSSYYPFSMGTRGCIGKNMAYHTIYLTVARLVFL
FEIESRDELPLEFHVKDHFAAGSKDGPYLKFTRREL*
>CYP549A1 N. crassa
AABX01000759.1 NCU01573.1 cont3.66 (version3)
39539
MLIALLAPFSLLIAYVLHHVLSHQTLLLKQIFSQTIFNTIQLARLIGPLD
PYDPLTVPDQVIPDSNSASEISEAQARANQRIDDARSIIDFSYAGPKIEL
EDRLRLRALANSRLVAAFGINTSLTSSSVSVHKKFRKLASASINKSRADW
QKLYGVCMDFLQREKARYGRTGIGLAECVRCLCFVVVLVSQFGVDDKKVD
KNLVKRITDGINAQWLKSKEDGEAVKTSDSLNHDLGMLFGNLKTSVAEEN
GTGKDTSIDPSEALGLIMPQYETLWRVVLLTYVTAYYTQYDKRSLKKRVK
DIPSCLGNAATEKEALKLAT
(0) 38580
38519
EGLRLYPSNNSIYRAATGPGPLKSADVQAC
HRDFNVWGRDALEFRPERFDNLTPLQEKAYFPFSLGSHKCPAFGGFGNRM
VTMLVVSMGRALSPETGKLNFEDAQLDNRVGIILPTGRDEMENWSWDMVR
V* 38124
>CYP550A1 N.
crassa AABX01000727.1 cont3.288 NCU05128.1 (version3)
125984 MTVENSIVQHALTVYHDLSTATKATLAISIAFILYRLLFRHESTRRKELP
AWGPIEMGLVMYLLDGARNGIVYRVY
(2) 125757
125699
SAIRRYGGSFYGISSANQTLIGYE
DVDRLFSSQMNHALSIEWHGYGLFLRFFGFPDTPTLKKKVESTFKPWHSP
IERVFNNDAGATAAFERGNLPKIVSEFVSFSQEKEKMKRWELRADIKVIK
QGEAVEANLSALIMDFGACFTIPPIFGHDLLDRNPHLIEDIWKFDHVVPL
LFINMPTWAPFKVMKEGIEARKRLLAGVEAFSRRVTQFQRGEKVDDGADI
SDVSDVVLERNTALERNEWSYQERAASELLVLFASNTNTQPVLFWLILYI
YSTPGLVNTLRQEVAPFITLSDSHHDKKGITAINTSGLSRECQLLKSIIL
ETLRLAFGAVSTRFVKRPITVQDGNHNHKLYPGTFLSVPHSFFQRDPSLY
PDPHKFVPDRFLETDPSSGKLVAKYGKLRPWGAGASMCRGRVFAEKELMA
IGAALVTLWDISPVGGGEWTVPEMVGGPGPVKPKEEVRVVIKRRVFGGVS
SSE* 124263
>CYP550B1 Fusarium graminearum FG05960.1
AACM01000237 FGcontig1.237_scaffold3
MVQLSALYQNAYATFASLSPVYKIIFTIVVIFVLRKAYGGQGKAY
KNLPAYAPIELAIASYVLSGDGISRRVF (2)
SSAISRYGGSLFGITSGHQIV
ADLPGIERLLTQSHHIFDSTPAQYSLCTLVFGSTNSPQLRDKLHTSLKDL
VPPLERTFLNDAASTAAVERSRVAERGASLVTFSSDPQHMERWELSAGIK
VLQSEQPGIPGKVEANLQSLTRDFGACMSIPLIYGQDLLDRHPQLLDDFW
VFDNELFPLLMVGIPTWAPFKMMQDGLKARTRIIDSLEGVYKRVEQERRG
ESIDFGADISDVSTMLRERNKVFNRDGWTLKERAAADLGTFWGLNANAQP
VLFWFLLYVYSTPGLLERIRQEISPYVTLVGGGRPEIASMDFQSLFRNCP
LFKACIFETYRLVNEPTSIRHVSQSVSINDGDLLHNLSEGTYISVPLALR
NKDPHLYQDPDSFVPDRFLDTDPQTGKSTARYGKLKPWGVGAAMCKGRTF
AEKEIISLGSAVVSLWDIAPADGSWKLPAMIPGTGVKKPINDIRVVIKRR
VL*
>CYP550B2 Aspergillus nidulans AN9214.1 55%
to 550B1 7 clan
revised 7/19/07
MDCISQNSVIQRALLALYEHPVAYSVI
TAVFISVLCRKLLYKPRNYALFPVWATIEVAIASYLLRGDGIGRRVF
(2)
SVIRRYGGSLFGITSTHQILVDFPGLDRFMARSLHTLNAEPVQYTIFTRTFGG
VDSPELKRKLKNSWKDLLAPIERLFLNDASAAAALDRACVLQQAASFVSF
SSSPAQMKRWELSAGIRVIPPAESGSPHKVEANLQSLTRDFGACMAIPLL
YGRHFLDGNPTLLDDFWKFDNELFPLLMIGVPEWTPLRIVKDGCAARARI
LRELEALYRRIDQSQCGEPVESGIDMSDVSGALFERSRIYKREGWSFPER
AAGDFAIFWGQNANTHPLLFWFLAYIYSTPGLLDTLRAEIAPYTCFASSQ
AKVPEITSIDFPGLSANCQLLKACLYETYRLVNEPISIRYVERPVTLTDG
SLQHTLKTGTWVSAAHSLTQHNASIFDNPAEFRPERFLETDQVSGKRVAR
YGRLRPWGAGAAMCKGRTFAEKELTSAAASIVSLWDIEPAYGQVWKLPGM
VPGTGVKRPVRDIRVLISRRQSIVVKGNDMSPSKGENHGKPLGV*
>CYP550B3 Nectria haematococca
e_gw1.2.919.1
Necha1/scaffold_2:2281734-2283431
MSNSTPTQALRHSLSACISFNVACTIATALALALLLRKFMFRPKTGSIFPVWAMIELALVSYIFRGDGIGQRIF
(2)
LAARKFGGSLFGLTSKHQVLVHLPDVDRLMEQSLHALSAEPVQYALLTRVYGGVDSPALKKKLENS
WRDFLPSMERLFLRESGATATIERARVAERAASLVTFSSDVQNLKRWELCADVRAIATDSQSSLAVVEAN
LYNLVRDFGACIAIPLLYGNDLLRQHPRLLEDLWKFDNDLFIPLLLGVPTWVPFKMIQEGLRARSRLLSA
MESLYRCIDQHQRGEVFNSEFDLSDVSSIPFERNKIYEREGWSLQERAAGDFSILWGQNANLQPMLAWLT
TFVYATPGLVEGIREETAAYINLSTIAPLEIISMDIPGLCRDCQLLKACIFETYRIANDPAVIRRVERPI
AIQDGELEHQLQAGSFVSMPTSLTNNDPAIFAEPDKFIPERFLERNPTIGNMTARYGRLKPWGMGSSMCK
GRTFAHKHLTVVGAAIISLWDIEPVSGAWEVPDMIPGSSAKRPAKDIRVVIKRRIL*
>CYP550B4 Fusarium oxysporum
78% to 550B1
FOXG_07659
MELSSLYQTASATFGSLPVAYKFLCAVLVIFAFSKAF
SGAERKGYKKNLPRYAPIELAIASYILSGDGIGRRIF (2)
SALSRYGGSLFGLTSGHQIFVDLPGVERLL
AQSHHTFNSDPAQYSLCTLVFGSTDTPELRAKFDTSLKDLVPPLERTFLNDAASTANVEK
SRVAERGASLVTFSSNPKDMARWELSAGIKVLQPETLDSPGKVEANLQSLTRDFGAC
MSVPLIYGQDILDRNPRLLDDFWTFDNDLFPLLMVGVPKWAPFRIMQDGLKARARIIDSLEAVYRRVDQYEKGEPVDLGA
DMSDVGMMLRERNKIYNRDGWTFPERAAADLGTFWGLNANAQPVLFWFLLYVYSTPGLLKRIRDEISPYVTLSDGAKPEI
KSMDFPSLFRKCQLFKACIFETYRLVNEPTSIRYVTQPVSLNDGNIKHDLQEGTYISVPLALKNKNPSIYEDPDTFIPDR
FLDTDPETGKATARYGKLKPWGLGAAMCKGRTFAEKEIISLGSAVVSLWDISPAEGEWKLPAMIPGTGVKRPVSDIRVVI*
SRRSPLKS*
>CYP550B4 Fusarium verticillioides
93% to CYP550B4 Fusarium oxysporum
no gene model
MELSPIYKNALATLGSLPLAYKVLCAVLVIFAFSKAFSGAERNGYKKNLPKYAPIELAIA
SYILSGDGIGRRIF (2)
SALSRYGGSLFGLTSGHQIVVDLPGVERL
LAQSHHTFNSDPAQYSLCTLVFGSTDTPELRAKFDTSLKDLVPPLERTFLNDAASTANVE
KSRVAERGASLVTFSSNPKEMVRWELSAGIKVLQPETSHSPGKVEANLQSLTRDFGACMS
VPLIYGQDILDRNPRLLDDFWTFDNDLFPLLMVGVPKWAPFRMMQDGLKARSRIIDSLEA
VYRRVDQYEKGEPIDFGADMSDVSMMLRERNKIYNRDGWTFPERAAADLGTFWGLNANAQ
PVLFWFLLYVYSTPGLLKRIRDEISPYIILSDGDKPEIKSMDFPSLFRKCQLFKACIFET
YRLVNEPTSIRCITQPVSLNDGNHKHELQEGTYISVPLALKNKNSSIYEDPDTFIPNRFL
ETDPETGKATARYGKLKPWGLGAAMCKGRTFAEKEIISLGSAVISLWDISPAEGEWKLPA
MIPGTGVKRPVNDIRVVISRRSPFKS*
>CYP551A1 N.
crassa AABX01000129.1 cont3.541 NCU08716.1 (version3)
67094
MAVLNWASSRAATLSPCPRTAALVVITTWLLYAIGLAVYRLYFH
PLARFPGRKMAAVTTWYEFYYDFWYGGKYIFEIEKMHKEF (1) 66843
66762
GPIVRINPHELSIHDPEYYNELYVGSSKRRTNFWPLFQGCTDDTD (1) 66628
66552
VNHFMTIDHDLHRQRRKPFDPFFSRMAINIRYWPMLAEKASFLES
RIRECKGQGKAVRLDRAFSAFSADCIERICTDDLEPGDGFLDQPD
FGPEWYDGMLGLIRNAPILTKFPKALS (2) 66202
66144
SLRYVPPRLLLWLFPQGRIANKYDARTRTQIHKAVTKQHLSKD
TTTNSEHTTLFRALAQSDNLSPADKAEERLVREAKLIFLGGTIS
TGRTLSFVSYYILSRPDIKARLEDELRDVMATWPEVVPTWTELE
KLPYLQAVIKEALR
(2) 65710
65588
LSYGFMRRLPRVSPDVAIQYKEYTIPPGTPVGMSAYLMHSNPEV
YQDPDQFVPERWLGGDTRVMQRSYVPFTKGSRSCLGQN (2) 65343
65254
LSMAEISLVLAVLFRPDGPRMELFETDESDVKHVHDFVVPLPK
LDSLGVRVMVR*
65090
>CYP551A2 Aspergillus oryzae
GenEMBL
BAE62699.1
53% to 551A1
43% to 551B1 Fusarium graminearum in CYP53 clan
Note 551 is
not in the 53 clan tree on part C where it belongs
MEDTFNLTVLGGVIVLYSLGLVIYRLYFSPLAKFPGSKLAAATGWYEFYFDYWIGGKYVFEIERMHQVY
(1)
GPIIRINPHELSIRDPDFYNEIYVTENKRRSNHYDLFARGIGMD
()
DARVESHIVTVDHNLHRKRRKPLEPFF
SRAGIARLEPALVEMSLKLESRLRQYEGKHTVVTLDHAFSAFSGDIIRRVCFNKDDFGDLFMDHPDFSPDW
()
YNLIHNILRHFPVFTGFPLIA ()
RIVTYIPESILLKAFPQGQSLNRLKDVALQRITHVMNSKATELKDTHR
EVSLFHHIVESDMPESERSPERLVQEAQVLLSAGTVTTARTIAFASFYILARSEIKAKLQAELRDAMDGW
PEKVPTFMDLERLQYLQAIIKESLR ()
LSYGIMHRLPRVSPDLPIQYKDFTIPVGTPVGMSSYFMHTDPTVY
PDPMTFRPERWLGAIDPAMHRNYVPFTRGSRNCLGMNLAMAEISLILAVLYRPNGLKLELYETDETDVMI
AHDFMAPMPKVTSKGVRVLIR
>CYP551A2 Aspergillus flavus
99% to CYP551A2 Aspergillus oryzae
AFL2G_08105
MEDTFNLTVLGGVIVLYSLGLVIYRLYFSPLAKFPGSKLAAATGWYEFYFDYWIGGKYVFEIERMHQVY
(1)
GPIIRINPHELSIRDPDFYNEIYVTESKRRSNHYDLFARGIGMD
()
DARVESHIVTVDHNLHRKRRKPLEPFFSRAGIARLEPALVEMSLKLESRLRQYEGKHTVITLDHAFSAFSGDIIRRVCFNKDDFGDLFMDHPDFSPDW
(2)
YNLIHNILRHFPVFTGFPLIAR (2)
IVTYIPESILLKAFPQGQSLNRLKD (0)
VALQRITHVMNSKATELKDTHREVSL
FHHIVESDMPESERSPERLVQEAQVLLSAGTVTTARTIAFASFYILARSEIKAKLQAELR
DAMDGWPEKVPTFMDLERLQYLQAIIKESLR ()
LSYGIMHRLPRVSPDLPIQYKDFTIPIG (0)
TPVGMSSYFMHTDPTVYPDPTTFRPERWLGAIDPAMHRNYVPFTRGSRNCLGMN
(2)
LAMAEISLILAVLYRPNGLKLELYETDETDVMIAHDFMVPMPKVTSKGVRVLIR
>CYP551A3P
Aspergillus nidulans AN5460.3
About 47% to CYP551A1
VTFYCASLIIYRLYFHPLAGYPGPKLAAATRW
YEFYYDVIRQGKYVYEVNQMHDKY ()
PIVRINPHEIVIKDPEFYNQIYVAGNTRRTEKWXXXXXXXXXXX
GSIVMTVGHELHRLRRKPLDPFFSRMEIDRLEPLIVKEAKLLNHRLQSYSGSGRVLRLADVF
SAFAVDMITHICSEAGPVMMNKPEFGKDW 224
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
ETKNSLFRQLLSPSSA
GGLPESELDAERLASETMVLFGAGTVTVTSTLSLICYYILRDSHIRDRRAGELEGVMAQYPTSMPTWQQLER
LPYLHALVQEGLRLSYGTMRRLPRXX
PDAALHYKQWTIPP (frameshift)
TPVGMAAYSLHTDPEVYPDPFEFL
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
(Missing PERW and heme signature)
LAYAEVYWALAVMFKSNAPKLQLFETEKMDVEHVVDSMVALLRLGSQETRITV
>CYP551B1 Fusarium graminearum FG01739.1
AACM01000092 FGcontig1.92_scaffold1
MERLKMDSLNININDWFEKDLPATADWKLFALASVVFVVLRFTCIVIYRI
YFSPLSKFPGPKLAAATHLYESYYDFWKKGQYYKVIQRMHEVYGPLVRVT
PDELSINDPDYYDTVYVNGNVRRTESFGHSFGGGLGIEDTFFASQDHDLH
RKRRKPIEPYFSRNGVLKLENLIGERVEKLFHKFHELSGTGVVARLDYAF
EAFTGDVMQHICIEKPESLLNSDDFSSEWFEMLRNVSLSVPLMGMIPWLV
HVLKFIPESVIMWLAPSAAHFQTFRVQAGRQIEQAKHEKVENDRKGITTV
GGKPTLFRFLVHESGLAPEDLSTERLQKEAMVLLGGGTTTTARTATMTCF
WMLSMPEKGQRLRDELKDIMAEYPKKKPSLTELEKLPYLGAVIQESLRMA
YGSMRRLPRTSPDVALQFKDWVIPPGTPVGMNAYYLHTDPNAFPEPFEYK
PERWLGNVTPAMKRSFVPFSRGSRRCPGSSLALADLHFVLAALFGPTGPK
FELFESDRSDVDAIHDYLMPLPRLDSKGVRVTVK*
>CYP551C1 Coccidioides immitis
51% to CYP551A2 Aspergillus oryzae
48% to CYP551B1 Fusarium graminearum
CIMG_09088.2 shortened at N-term
MEAYLPKNLGLRATVAILVISVFYILSLVIYRLFFSPIAKFPGPKLAAVTGWYEL
YYDVVKKGKYLFEIEKMHDKYGPIVRINPHELSIRDPEYYDELYVAGSVRPTERYKGFVDGIVDFDGSHLATIGHDLHRK
RRKPLDPYFSRAGVTKLEPMVAELCEKLIIERFEGFKGTGKVVRLDHAFTAFSGDVINRICIDDPPNLVDDPEFAPWWFE
LFHSGIVSLPLFMGLPWLIHFIRLIPESILAKLDARSQTFNKFKLMCDEHLRVAKREKAALGSKDTTAMGGRLTLFRHMV
SSDLPPSELTDERLSKEAQVLIGSGTITTAGTMGFLCYHIMANPAIRKRLEEELKPVMEGYPQRKPTWAQLEKVAYLQAL
VKEGLRLSYGTMHRRPRVSPKQALRFKEWVIPAGVPVGMSAYFAHRNPHFFPRPLEFIPERWLENVTPEMNRNFIPFSKG
SRHCLGMNLAYCELNHILAALFRPGGAGFSLYETDESDVMPAHDLIVPLPKLDTKGVRVMFH
>CYP551C2 Aspergillus clavatus
75% to CYP551C1
ACLA_076840
MEASLHFPIDASLRAAVAVISAGAFYLLNLVIYRLFLSPLAKFPGPKLAAVTSWYELYYDLVHKGKYLFEIEKMHDKYGP
IVRINPFELSIRDSEYYDELYVAGSVRPTDRYEAFVEGIVDFKGSHIATIEHDLHRKRRKPLDPYFSRLGVSRLEPMLGE
LTEKLIVNRFESFKRTGKVVRLDHAFTAYSGDVINRLCMDDPPDVLVDDPEFSPWWYNMFHNGIATLPLFMGLPWLIHVV
RLIPVSILAKLDPGTQTFNKFKMMCDDHLRVAKREKAAQGSKDTSMMDARPTIFRHLLNSDLPPSELTDDLLSKEAQVLI
GTGTITTAGSLCFICYHIVVNPAIKKRLQEDLKLIMANYPAKKPTWAELETATYLQAVIKEGLRLSFGTMHRRTRVSPKQ
PLQFRQWTIPAGVPVGMSAYYAHRDPSVFPRPDEFLPERWLSNVTPEMSRNYVPFSRGSRRCLGMNLAYAEINHVIATLF
RPGGPDFKLYETSEKDVKPAHDLIVPLPSLESKGFRVIFR*
>CYP551D1 Mycosphaerella fijiensis
49% to CYP551C1 Coccidioides immitis
e_gw1.2.71.1
MQQHIASSSLLLVVLAITLIYALGVVFYRLFYHPLAKFPGPRIAAATYLYEIAFDYFGHGAYLFEIERMHEKYGPVVRVN
PKELSIKDGEFYDKVYVNGNVRRTEALPSFGDGMDFNHSHGMTVDHHHHRMRRKPLEPFFSRAGVARFEPNLASVVMTLV
HRLRGWEGTGTVLRLDHAFAALAGDIISTMCIESPSMSFLEDRDFAPDWYNLFHTLITSMPIFMNFPWIIKAVRLIPTSI
LKRVDPRSQMFRDWLAEIEKSLRRKANKEVSTYQRGTLKAPTLFDHLVNSDLPSSEMSVERLASEAQVILGAGTVTTAQS
MSHLVVNILLRPEVENRLREELATLMKHLGEARLPEARELEKLPYLQACIKEGLRLSHGLMHRLPRIAPDVALDCNGWII
PPGTPVGMSAYLMHMDDSVYSNPKEFVPERWLGEPDPKMERNYVPFSRGSRRCLAPNLAYAEISMVMAALFSPWSPKIRL
YETNASDVDPVCAFLLPLPRLDSKGVRVIVEESKDNSK*
>CYP551-un1 Magnaporthe grisea MG06589.4
53% to 551A1 PERF to heme
probable pseudogene fragment
AACU01000192.1 cont2.1224 continuation of
MG06588.4 +1800bp
FGFMVRLPQCSPDVKLQYGKWKTPRN (0)
TPVGILAYLMHTD
79064
PTIFAEPYEFRPEGWLEGQVISAMKQAYVPFSKGSRACLGSI (1) 79189
>CYP552A1 N.
crassa AABX01000480.1 cont3.625 missing about 32 aa
at N-term (GC
boundary at exon 2?)
2
FFHPLRHIPGPKLAAASYIPEFYWDVLRGGMYQKRILLMHEKY (1) 130
229
GPVVRISPNEVHCNDWRFIDEIYASGSRKRDKPLHQVRGSGG (2) 354
419
IVDATFSTTSHDLHRMRRNALNKFFSRAQVARLEPTVRENAERIC
DKILILGKSAPFDVTTAYSHFTTDVISGYCLGDSLGLIEQKGWEP
NFREPLYAQLKLMYWLRFIPLFKRLS (0) 766
888 WYVFFGESFLPCPVSLTNYDIQGDMPRYVRRAQDNVIKGLDDG
SSVFGALLTSDLPPSEKSLERLTDEGFSLFAAGTETVSWALSVIT
YHLFANRELLEKVTKEVTQVIDAKSGQLPSWHTLEKLPYLGGVIY
EGLRLSYGVASRSSRIPVGEDLVYRG (0) 1364
1407
YVIPRGYAIGMSPLSIHHDETVFPNSHSFIPERWIDDNDQHRKEL
DRALLSFSKGSRSCLGIN
(2) 1595
1657
LAYCELYVLLSLLIVRVFPHMKLHETTEVDVTHDHDFFNPFPVSS
SKGVRAIVV* 1821
>CYP552A2 Aspergillus nidulans AN2040.1 53%
to 552A1 50% to 552B1
AACD01000032.1 revised 7/18/07
MTISAETVLRLLPLTAGGAWVFFHLAKCIYNLFFHPLSHIPGPWLAAATY
LPEFYHDVVRGGRYTTQIQQMHEKYGPIVRINPHELHCNDHRFINEIYAG
GTRKRDKPVHQVTGSEAAAHATFSTTDHDVHRMRRNALAKFFSRAQVLRL
EPTVRGLAERLCDKMLRTEKGRPFHVGAAYSQFTADVISGYCLGENLGLM
GQEGWEEQIVDEVATVLRLGCTLRFVPWWKHVLGVVLLIRKQLVGSPKES
SDALIVGMPNHIRKAQADIKIMDGKGNGNGPETIPTTVFTSLLQSDLPPQ
EKTFERMTSEGISLFAAGTATVSWALTVATYHLLTKPAILQRLTAEVSDL
VNSSSCTEKVEWSALERLPYLGAVIQEALRLSYGVASRTARVATGEDLVY
RGEWAHREVQYIIPRGSAIGMSAVLAHHDEAVFPDSHLFLPER
WLDEKNQRLKELDRALLAFSKGSRGCLGIK
LAYCELYLLLALLVVRVFPRMRLYGTTEADVAYDH
DFFNPFPVWESKGVRVVV*
>CYP552B1 Magnaporthe grisea AACU02000500.1
Magnaporthe grisea 70-15 revised
MATTLVTAQNLLGLAVLWIVYQVLKALYNVSPFHPLAHIPGPKLAAATYL
PEFYHDVVLFGRYTHEIRDMHRKYGPIVRINPNEMHCNDVNFSDDIYAVG
GRKRDKPQHQINGAVLGKSGFGTRDHDLHRTRRIPLAKFFSRAMITRLEG
DMHELVQKLCDKLLAESGKKEPVDVTVAYSCFTSDAISGYCFGESFGFLE
QQGWYPNFRDPTAATLRIAFLLRFFPWCKYFMVVGHWLVDFLPTDIALLI
QTMQIDMPIRVVKTKTDMDSGIQYKRPTVFGSLLHSELDPSEKEPQRLAD
EAGAVIGAGTETASWALAVITFHLLSKPHLLEKLQAELRQVVDGSNNDNS
PKSLPPRSVLETLPYMNGVIQEGLRLSYGVSGRTARVATHEDLVYRGTFG
76746
GNPVEYVIPRGYAVGMSAAVTHHDENAYPDSYEFIPERWMDGHSKKRDAE
RASLAFSKGSRSCPGKS (2) 76940
LALAEMNLALAALALRVLPHATLYETTYDDVLYDHDMFIPRTRKESKGVRVKIN*
>CYP552B2 Magnaporthe grisea MG03828.4 51% to CYP552 AACU01001030 cont2.747
MSTTWLLGQSPFAIIAGTWILYQVLKVLYNLSPLHPLSHIPGPRLAAATY
IPEFYHDAILVGRYTHQIVEMHRKYGPIVRINPNEVHCNDVNFSDEIYAV
GGRKRDKSIHQINGAVFGRSGFGTIDHDVHRMRRAPLGKFFSRNNIAKLE
SEIHNLVQKLCDKFLKDSGNVIEIATAFSCFTSDAISGYCFGESFGFLEQ
DGWYPNFRDPALSTVKPIFFFRFFPWTKSFLILVPWIINYLPTDVALLIK
TMQIEMPGRVQKTKAEIESGMSLQYKRPTVFGSLLESDLPEEEKSGARLT
DEAGAVVGAGTETTSWSLSVMTYHLLAKPEVLQRLQDELRQVVDDPKNLP
PWSVLEALPYLGAVIQEGLRLSYGVSSRTARVATEEDLVYRGEFRGRPLE
YVIPRGTAVGMSAAITHHDERVYPNSHEFIPERWLKDKDDPQRKEAERAL
LAFSKGSRGCPGKTLGLCELTLALSAVVLRVLPHARLYETTIRDVAYDHD
TQVPRTVKESKGIRVVIN*
>CYP552B3 Fusarium graminearum FG11038.1
AACM01000458 FGcontig1.458_scaffold8
MDSNYDSVQGAIASLTIRQWVIVTVVSWFVYKIVEALYNISPLHPLSKVP
GPKLAGATYLPEFYHDVILVGRYTHAIQKMHEKYGPIVRINPNETHCSDM
AFSEEIYAVGGRKRDKPFHQVNGSAAGTGNAFGTPDHDVHRSRRGPVAKF
FSRAMIARLEEEVHELAQTLCNKLLAESSGKEKSAPIDVAHAYSCFTSDA
ISSYCFGEAFGLLSRDTWRPTFREATLAVLKPVFVFRFFPFLVGSVKYGK
HFVDYLPADAAMLVRTLQIDIPARVTKTKTDLNSGIVYERPTIFADLLQS
ELDESEKGTDRLVEEAVTIVNAGTETTSWALAVITYFLLSQPETMSKLQA
ELATVVDDPRHLPSWTTLEKLPYLGAVINEGLRLSYGVSSRSARVPTTED
LIYRGEFNKQHTTIVLPRGYAIGMSSAISHHDESVFPDSYSFTPERWIDD
DGTIRKNLERSMLAFSKGSRGCLGKNLALCELYLSLTALVMRVMPHMTLY
NTSERDVRYDHDMFIPVTVKGSTGVRVTIEA*
>CYP552B4 Fusarium oxysporum
79% to CYP552B3
FOXG_02774 revised
MADATWSAFQGTLTSMTARDWIVALTSAWLAFKVLQALYNVSPLHPLS
KIPGPKLAAATYLPEFYYDVILVGRYTHAIKQ
MHEKYGPIVRINPNELHCADMSFSDEIYAVGGRKRDKPFHQVNGSAAGTGNAFGTPDHDLHRARRAPVAKFFSRAMIARL
EQEVHDLAQTLCNKLLAENKDEKERKPFEIAHAYSCFTSDAISSYCFGEAFGLLSRNQWQPNYREATLAVLKPVFFFRFF
PILVSSVKL GKYLVDYLPADTALLIRTLQIDIP
SRVQKTKNDLDS GIVYDRPTIFA
DLLQSELDDSEKKQDRLVEEAVTIVNAGTETTSWALAVITYFLLSQPEILAKLQDELKQVVDDPCHLPSWT
TLEHLPYLGAVINEGLRLSYGVSSRTARVPTTEDLVYRGEFNKKPMSLVLPRGYAIGMSAAIAHHDESVFPDSYAFVPER
WIDGDNKIRKDLERSMIAFSKGSRGCLGKNLALCELYLSLAALVLRVMPYMRLYETTERDIRYDHDMFIPMTESGSKGVR
VIIES*
>CYP552B4 Fusarium verticillioides
92% to CYP552B4 Fusarium oxysporum = ortholog
FVEG_01613 revised
MADASWSVIHGALTSLTAQDWTVAFISCWFV
FKVLQALYNVSPLHPLSKIPGPKLAAATYLPEFYYDVILVGRYTHAIKQMHEKYGPIVRINPNE
LHCADMSFSDEIYAVGGRKRDKPFHQVNGSAAGTGNAFGTPDHDIHR
ARRAPVAKFFSRAMIARLEQEVHDLAQKLCNKLLAENKDEKDRKPFEIAHAYSCFTSDAISSYCF
GEAFGLLSRSQWQPNYREATLAVLKPVFFFRFFPI
LVSSVKLGKYFVNILPTDIALLIRTLQIDIPSRVQKTKNELDA
GIVYDRPTIFADLLQSELHDSEKKQDRLVEEAVTIVNAGTETTSWALAVITYFLLSQPETLAKLQ
DELKQVVDDPCHLPSWTTLEQLPYLGAV
INEGLRLSYGVSSRTARVPTAEDLVYRGEFNKKPTTLVLPRGYAIGMSAAIAHHDESVFPDSYTFA
PERWIDEDNKIRKDLEKSMIAFSKGSRGCLGKNL
ALCELYLSLAALVLRVMPCMRLYETTEKDVRYDHDMFVPMTESGSKGVRVIIES*
>CYP552C1 Magnaporthe grisea MG06623.4 41% to 552A1, 46% to MG01924.4
AACU01000198 cont2.1232
MDSSMELGGGPGGVAVLTFKSIAWMVGLWMVYKVGVALYNISPFHPLAAF
PGPKIAAASYLYEGYWDFWRVGRYTKVIEQMHKKYGPIVRINPDELHCSD
PLFVHEIYAGPGRVRDRWQHAINTGGSGPIAVTGFSTISHELHRQRRAPL
NRFFSRQQMLKLEGEVLDYAQRTVAKMLRTEAGRGAFEIKEAFNCFTADV
IGQYAFGQTMGFVDQEGWEPSFATMVGSFLRSAYVMRHVAIARWASGFLP
FMADYLGEDIRYVMNMLAVTIPGYIKASLDDPQNGRVFADLMQDDKMPEE
EKSMYRLSGEGFNFLLAGTETTAATLTSLTFHLLDQPKLYARLMKDLEGV
DPDKPKWTDVERRPYVWALVHESLRTMPGVSHRSARIAREEELVYKSQDG
KWSYVVPRGTPIGQTSMISHWDEKLFPDPDRFDPERWLLEDGTPNVALAK
YLIAFGKGSRSCLGENLAYCEVYIMLALVAYKILPRAKLVDTTIEDLTYD
HDLIVLQTKKGSISVKVAIE*
>CYP552C2 Fusarium graminearum
AACM01000116.1 Gibberella zeae PH-1 revised
MDSKSTWETVDVRGIASFKSVATLVGVWFLYRIFVALYNISPFHPLSRFP
GPKIAAVSYLYEAYYDWWRVGRYGKVIRDMHERYGPIVRINPDELHCSDP
YFTDEIYAGPGRVRDKWQHQLNTGGAGPVSVTGFSTVNHEVHRMRKGALS
KYFSRSQMLKLEGEVRDFSQMTVDKMLRYAGGEPFDVKEAFNCFTADIIS
QYAFGESMGFIAQEGWEPNLATWVKSFFQSAYMMRHNVLARKMAQFLPFL
SDYLGEDIKAVMRQMNVVIPGYIKAALKNPDGGRVFAQVVESKTLPESEK
SLYRLSGEGFNFLLAGTETTAATLTVITYFLLDKPEIYKRLMADLDGLDP
ENLKWTDLEQRPYLWAVIHEALRVMPGVSHRSARIAREEDLVYQSQDGNT
NWVIPRGTPIGMTSMINHWNEDLFPEPDEFLPERWLENGKPNYKLQKFLI
SFGKGSRACIGEN (2)
182057
LAYCEVYIMAALMAFRVIPRARLYETTIEDLTYDHDLIVLQTKKGSISVRIAIS* 182221
>CYP552C3 Fusarium graminearum FG08186.1
AACM01000329 FGcontig1.329_scaffold5
MDDFNIIALKRFVSPSALLGLAGLWLGYRVALALYNISPFHPLSKFPGPK
IAAASYVYEAYYDWILQGRYGRRIEKMHEQYGPIVRVSPDELHCSDPYFA
DEIYTGKPGRIRDKWQHHLKIAGAGPASQATGTAGPHELHRKRRAAHARF
FSRGQVLKLEDEVLKFAELFIQKMLRWNGKEAFEVKGAFNCYTADVFSQY
AFGEPMGFIEQEGWEPNFGTWTSSFLKTTYMMRHNALARRLADILPIFAD
YMGEDVKRIMHQMNHVIPAYIKTALANPDGGRVFNEILNSNVLPEEEKTM
FRLSGEGFVFLLAGTETTAAILTVMTFQMLHQPKVYARLMKDLEGIDPNN
LKWAQLEQRPYLWALVQESLRHQPGAAGRSARIAREEDLFYKSQDGKTQF
MIPRGTPVSMTAMINHWDTRLFPDPDSFNPDRWLLPDGKPDYTLQKFLIS
FSKGSRVCVGESLALCEIYIMAALMAFRVIPKSELFETTIEDLTYDHDLV
VLQTKKGHISTRIKIS*
>CYP552C4 Fusarium oxysporum
84% to CYP552C2
FOXG_10802, not in the F. verticillioides
genome
MDQMAVLPASITAAALFQTIAYLFTSWLAYRILLVVYNISPLHPLYRFPGPKIAAASYLYEAYHDWWRVGRYGREIRRMH
ERYGPIVRINPDELHCSDPYFTDEIYAGPGRIRDKWQHQLNTGGAGPVSVTGFSTVNHEVHRMRKGALSKYFSRQQMLKL
EGEVQEFAQMTIDKMLRYAGGEPFDVKEAFNCFTADIMSQYAFGESMGFIAQDGWEPNLATWVKSFFQSAYMMRHNVFAR
TMAQLLPFLSDYLGEDIKAVMRQMNVVIPGYIAAALKNPEGGRVFADVMESKSLPESEKSMYRLSGEGFNFLLAGTETTA
AILTVITYYLLAQPLTYRRLMADLEGIDPQTLKWTELEQRPYLWGVIHEALRVMPGVSHRSARIAREEDLVYKSKDGNVE
WVIPRGTPIGMTSMINHWDKEIFPNPDNFTPERWLEGGRPNFKLQKLLIAFGKGSRACIGENLAYCEVYVMAALLAFRVI
PRARLHETTIEDITYDHDLIVVQTKKGSISVRIAIS*
>CYP552C5 Fusarium oxysporum
92% to CYP552C3, 65% to 552C4
FOXG_12228 revised, not in the F.
verticillioides genome
MDNFNSIALERLLSPSALFGLTGLWLGYRVALALYNVSSLHPLSKFPGPKIAAASYVYEAYYDWILQGRYGRRIEKMHEQY
(1)
GPIVRVSPDE
LHCSDPFFADEIYTGKPGRIRDKWQHHLKIAGAGPVSQATGTAGPHELHRKRRAAHARFFSRGQVLKLEDEVYNYAKLAI
EKMLRWTGKEAFEIKGAFNCYTADVFSQYAFGEPMGFIEQEGWEPNFGTWTSSFLTTTYMMRHNGLARRLADILPMFADY
MGEDVKRIMHQMNHVIPAYIKTALANPDGGRVFNEILNSNVLPEEEKSMYRLSGEGFVFLVAGTETTAAILTVMTFHLLH
QPKIYARLMKDLEGIDPNNLKWAQLEQRPYLWALVQESLRHQPGAAARSARIAREEELFYKSQDGKTQFVIPRGTPVSMT
AMINHWDTRLFPDPDAFNPERWLLPDGKPDYTLQKFLISFSKGSRVCVGESLALCEIYIMAALMAFRIIPKAELFDTTIE
DLTYDHDLVVLQTKKGHISTRIKIA
>CYP552C6 Aspergillus terreus
80% to CYP552C4 Fusarium oxysporum
ATEG_03758.1
MNFMIDMNVGLKAALTVFYLIALWAGYRVL
IALYNISPLHPLSRFPGPKIAAASYLYEAYFDWWCVGRYGHEIRRMHERY
GPIVRINPDELHCSDPSFTDEIYAGPGRIRDKWQHQLNTGGAGPVSVTGFSTVSHEVHRMRKGA
MARFFSRQQTLKLEGEVHEFAQLTVNKMLGFAGKAPFDVKEAFNCFTADVISQYAFGEPMGFIAQDAWEPNFATWVKSFF
RSAYMMRHNALARKMAQLLPMLADYMGEDVRAVMRQMNVIIPGYIEQALREPGNGRVFAEVVQSDLLPESEKSLYRLSGE
GFNFLLAGTETTAATLTVITYHLLAQPSIYARLMDDLQGLDPASLKWTELEKRSYLWAVIHESLRMMPGVSHRSARIARE
EDLVYKSRDGRVQWIIPRGTPIGMTSMINHWDEEFFPSPDRFLPERWLVDGQPNYKLQKTLIAFGKGSRSCIGENLAYCE
LYIMAALMALRVVPRARLHETTVEDISSYDHDLIVVQTKKGSISVRIAIS*
>CYP552D1 Magnaporthe grisea MG01924.4 poor match 46% to MG06623.4
AACU01000373 cont2.362
MGGILVHVGQAVPTATMAAAYIAGALILYQSAVWAYQISPFHPLAHIPGP
KIARVGRLYEAYWDWWRGGRYMNKIAEMHAQYGPIVRIGHDEVHCSDPNF
SSTLFGSPNQVRDKPQHMCNILVSGALPHSTIVTTSQALHRARRAPMSRF
FSRAHVFRFEDEVLRLASVVADKMLLPERRGKSFDVRDAFNCFTADVVFL
HALGKPLGFVEMQEAWTPNLATWTEMMTDMVYLIKHNAWARWAAIVTPKL
AGMFSTSVKALNELMNVTIPGLLKSATDDVENDRMFPILLRGGMDGKSQV
APGAEMDMFRLGGEATVLLTAGTETTSAALAIITYHILARPEVKAALAAD
LAGLDPTALKWTELERRPYLWALIHESLRHSPPIVARSSRIAPLEDMVYI
PRARDKSADPAPPVTIPRGFTVAMSTITSHYDPTIFQDPAEFRPERWLVK
DGDGNVIGNNEELKKSLLTFGRGSRACIGENLAMCELFIMTAMMALCVIP
RARLDDRMTADYVTYDHEKLTLQTIYGNVATHMVVS*
>CYP552E1 Aspergillus nidulans
AACD01000108.1 Aspergillus nidulans FGSC A4 revised
MDFLMEYGSPAGFFTIFATL
WLVYCLLRMLYNVSPLHPLSHIPGPNLAAATFLYESWFDLVLGGKYTHKIKRMHEQY
(1)
GPVVRINPEELHFNDISFANEIYAGPGRKRNKQVHYLNIFAGPTTSS
MLATVEHGHHRVRRSAVNRFFSRAQISKLESNIKDLALGLCDKMIRL
(1)
AYSCFSGDVISKYCFGEPFGFIAQEEWEPNYRNALKATQAPVHVFR
TFPFLKRLTDIAPLCARWASPGIREMLIESNEKMPARIRKARQDSKRGIT
ETQPSLFAALLDAPLPEAEKTDQRLGGEGFLMIAAGTETTAWTLTVITFH
LLNQPDTLNRLRCELQDADALNLQWFALERLPYLTAVIHEGLRLSYGVSQ
RISRIAPTETLVYQGEHNGRRIEYSIPSGTTMGMSNAINHHNEDAFPDSD
AFIPERWINIDDAQRRRMDSCLTPFSKGSRQCLGINLAYCNLYLALTALT
LRVLPWMSLYETTVDDVRYHSDLFAPLPKKGTKGVRAIISYP*
>CYP553A1 N.
crassa AABX01000379.1 cont3.619 NCU09565.1 (version3)
26616
MPSTMADAVAEIESLLDTGIAAIKGLIP
MIWVQSKTSPVQFLVGGVAVLLSYLLLTISPPHDPSEPPLIKPR
FPVIGHLFGLLNHQVNYFSELFARYHLPIATLPIGNQKLYVIFD
APLQQAALKAKDMDAQSFMVDFVPRIFGVKQGTVDKLLGKDGVH
PNIMGDMEQVFKSALSGDNLQKLASTTLATMADTLNDVDSKKGT
KIPNMFLWLQSLLSRSTSKALWGEKHNPFKDHQVIDAQW (2) 25888
25827
DFESHLGPLVLGVLPSIVARRAYLARNKVQSALLSYFSARHYET
DPSTSYFIRARTRLLKRYDLPDDELAKNEVAITLVATTNVLSTL
FWCIAEIWTRPDLLQQIRAEALLAVFGNSQKALSGEDMGTRTIT
IPATGLDAKCPLLASCFRESIRLASQIVTARRVLKDTLLTDPVS
GNSYLLKADTNVMMPAKVVHRNTSVWGADAEGFNPRRFMWEELG
PKVERQRKAAFVPFGGGKHMCPGRHFAFTENLALMAALAIGFEI
EGLDRSKLKMGDSKRGETAKPLPGLEGGEVVLKKRKGWEGVEWEFSC*
24892
>CYP557A1
AY316198 Rhodotorula sp.
MLALVCVGLFLYLLCKYRSHAIATSDRTDLAGPKGWPLMGVFKF
PLPTLSVTYVVVDVTEKTLSGNLIFYATQSSTRGLEWGVRFVKTYGHAWTLSVPGLRL
IDISTRPDWIEYVQKTNYHNYVKGSAFRNRLSDIIGNGIFVTDGRVWQFQRKVTSHIF
TGRSFQDAICPAIAEELRSLNKLLDNYADTGETVDLQDVFYRFTFQAFGRFAFNLDLR
NLEIDHKPVPFTTAFDQCQKPSLDASSTRSGAFASALPLPAVEYQTPPSCFRLCLRND
DKRAALLAKKDAKVPSDLLTMFMTARYDDSRPLSRVEIRDAIINLLLAGRDTTAQSLT
WALYRLVDNPAHQRLVREEICGQLAGGTEPVTLENVKNLVQTQAAHLESLRLHPPVPR
IVKQAVKDDALPNGGPLIKAGEFIRLSDWALGRNEEVWGADAKEWKPSRWIDDEGRPI
QYSQWKAHFFNGGPRICLGKSLATLEGVAVIANLLHRYNIAFAPGWWENVEKTGRIAG
DLEETPLYGPALTLPMKSPFWVTISRR
>CYP558A1 # Achlya ambisexualis (not a fungi, an oomycete
Stramenopile)
No sequence confidential
>CYP559A1 N.
crassa AABX01000439.1 cont3.339 NCU05967.1 (version3)
53814
MAITSLSSHLLESLLASLTLGRVTALVILFTIASFAIDSTRKPTYPKSLP
RVGFTGGIGATVRNWMNLGNYHNWVEEGYNKYGKHGRSFVTPSSPSQPDE
IVVPQEQIAWMLEQPETVASTQESHKDVLFGTYNFFNVDDHFPTKVMHKH
LARNLVTLLPDIQQEVAESIDIAFGTDTENWTTLNLWEALLAIVPRVMNR
LAVGLPLCRNQAFLSSQVGFADDVFRNCLILTLFPTVLHPLVGRLVTLPN
WYHFHQGYRLLKPVIEQRLRDYERFESGESQTPPEESLITWLIRQAKADN
LPHEQTPYMIAMRLLPIEFAAIHTTVITLHALFLDLLASDPSKDYLSILR
EETTAVLQSEPNGIWTKNGLAQLYRTDSAIRESMRLSTFSTGLTHRKVVA
KEGITNPFEGWHAPYGAILMANMSVQHDADIYEDPKTYDALRFSRVREEY
EARSQEEVEKGKETEEALRIKRLGVVTTSSEFLPFSHGRHAC
(2) 55289
55352
PGRFFVAHEVKMMLAHILQNYDIKPIAERPRPTWVAHTIIPALD
VKIEVKRRQRKK*
55532
>CYP559B1 Magnaporthe grisea MG00572.4 50% to 559A1 AACU01001430 cont2.99
MAGENLPLEILDRISVGRVLAGIFLFVVTSFIVDILQQPSYPKSLPRVGY
GSGPISTVRNWLGYVFKFPQWVDSGYQKYSKEGKAFVVPSAASRPQEIVV
PRTQTAWMLDLPERQLSSAHAQSDVLYSEYQFLGSEFATDSFHINIIHRN
LTRHLSTLIPSLQDEVQVAVDETFGTDTENWKEFNLWESWVKLVPSVINR
VLVGPELCRNKELLNSMVHFADTVVMNSFILSLFPKTLQPIIGRALAVQN
WRLYKKAHKILEPVINERLEMMARKDAGNHAKMADWEPSEDFITWAIRMA
RNEGRSGELNSVNITKRLLPIEFAAIHTTVITGHFLLLDLLTSDPKKGFM
ESIRQEASSMLQRSGGRWTKDGLWNLYRTDSAIRESQRLSIFATSLTKRK
VVAPEGITNPVEGWHVPQGGYLMLNLDGPQHDEDLYENPKEYDAFRFSRP
REEYEARPADKKDLEEYMQLKKLGMVTTGDAHLAFGHGRHACPGRFFVAH
MLKMTVAHLLCNYELEPLPEKPKAAWMGQLIIPPVDVKIRLRRRKQTA*
>CYP559C1 Nectria haematococca
fgenesh1_pg.scaffold_20000187
Necha1/scaffold_20:493296-494983
47% to 559B1 Magnaporthe grisea
MEIDISRLFLYAVVFLVVSFIIDALCQPKYPTEIPVLGSKGWFSKIRNSFAYFTKHQSWIDQGYQK
(0)
YGKNGLAFIAPAPISRPPDVILPRSQIPWMMDQPDHILSAVKAHDQILYTEYNFLGNHLSHEPFASRVVHKYLA
RHLPSLIKPIEEEVNAAVEDSLKLKQDGYTKVNLWELWMAIVPRVTNRLLVGEETCRDDVFLQSMIRFTD
DVVRNSFLLHAFPKILHPIVGRLLTIPNYLHWRAASRRVLPIIQQRLENMRRKDAGELKDWTPPEDFITW
DIRLAMAEGKPFELDPVVISKRLLPINFAAIHTTVLTGHSWMLDMLSSPPSENILETLLSEINTHKPTTG
WTKQSLTSLLRVDSSIRESQRLSNFAANLIERQVVSPTGLHNPEYGWTLPKGAFVTVNLQGTHHDEDIYE
GAMSYDPWRYSRVREAWEGKSEEERKDEDGVKVRGLGMVTTSDAHLAFGHGRHAC (2)
PGRFFVAHELKLIMAAFLLNYDIKMIDQRPKPQWMGATIIPPLDACIEIRRKSKS*
>CYP559C2 Fusarium oxysporum
71% to CYP559C1 Nectria haematococca
FOXG_06404
MTVLGDQLTEVTFTRVLLFGSLFLLVSFIVDLLTQPRYPSEIPVLGHSSEKWFSRIRNSLAYFTQHQAWIGEGYEK
(0)
YGKNGLPFIAPAPISRPPDVILPRSQIAWMMEQPDRILSASHAHDKILYTEYNFLGKDLAAEPFANRVMHKYLARNLSSAIPAV
EDEVNGAVEHALETMMKAAAEKDPKNVDGEGYTKVNLWDLWLAIVPRVTNRLLVGSPACRNPDILKSM
VSFTDNVVMNSF
LLHGFPQVLHPIIGRLITIPNYLHWRKASHVLLPIIEQ
RLKHMQRQEAGDPEMKNYTPPEDFITWDIRLAMAEKKPFELD
PVVISKRLLPINFAAIHTTVLTGQSWMLDFLSSPPSVLDALRNEILEHKPSEGHWTKQALSSLVRVDSSIRESQRVSNFA
ANLIERQVIAPEGLHHPDYGWTLPRGAFVTVNLQGTHHDDEIYEDAMSYDPWRYSRVREEWEAKSAEEKQEKEEEAKKIR
GLGMVTTSDAHLAFGHGRHAC (2)
PGRFFVAHELKLIMAAFLLNYDIKTLEKRPKPQWMGATIIPPLDACIEIRKESTT*
>CYP559C2 Fusarium verticillioides
95% to CYP559C2 Fusarium oxysporum ortholog
FVEG_04255
MTVLGDIFTEVTFTRVLLFGSLFLLVSFIVDLLTQPRYPSEIPVLGHSSE
KWFSRIRNSLAYFTQHQAWIGEGYEK (0)
YGKNGLPFIAPAPISRPPDVILPRSQIAWM
MDQPDRILSASHAHDKILYTEYNFLGKDLAAEPFANRVMHKYLARNLSSAIPAVEDEVNGAVEHALETMMKAAAEKDAKN
VDSEGYTKVNLWDLWLAIVPRVTNRLLVGNPACQNPDILKPM
VSFTDNVVMNSFLLHGFPQVLHPIIGRLITIPNYLHWRKASRVLLPIIEQ
RLKDMQRQEAGDPEMKNYTPPEDFITWDIRLAMAEKKP
FELNPIVISKRLLPINFAAIHTTVLTGQSWMLDFLSSPPSVLETLRDEILEHKPSVGHWTKQALSSLVRVDSSIRESQRL
SNFAANLIERQVIAPEGLHHPDYGWTLPRGAFVTVNLQGTHHDDEIYEDAMSYDPWRYSRVREEWEAKSAEEKQEREDEA
KKIRGLGMVTTSDAHLAFGHGRC (2)
GRFFVAHELKLIMAAFLLNYDIKALEKRPKPQWMGATIIPPLDACIEIRRKKST*
>CYP559D1 Mgr051 Mycosphaerella graminicola
42% to CYP559B1 Magnaporthe grisea, 41% to 559A1,
39% to 559C1
MELLTLVLQHPFLAIAAVLVGLYAYALVTGSSKPAVPGELPWVGKKDGQWFSLTRATWMSVGKARQWLHEGYTKFGRNGKSYLFPDVSGRHEIVLPPDQLRWLTNLPDSTTCVRAAHYDILQGDYAFTDKYLLESFHERVIHKNLARKVDATIPAMWDEIDASFRDIWGTDTTQFKDIPLWDSVMAVIARLSNRLFVGLPLCRDKDFLAVSGSFAMDVITLVSLLPLFPKFLQPILGRLGSLPGHYHYWRTRKHTLPIIRQRLADITALAADPTTKLDRPIPEDYITWHIRTAMADNRPKDLDPVMISRFLLPIEFAAIHTTALTLTNILFDLYSSDPSQNYIASLREEATRLHAECNGNWTKQILTRMLRTDSAIRESMRISNFATRAVLRKVISPAGLTHPTENWHTPEGSYVSVDQHSVHHDPAVYPSPEIYDAFRFSRPREEFEAKHAGSDAKTLAQDPEYLAMRNLSMTTTGENFLAFGHGRHACPGRFFVQHELKMVVAYVVMNYEVEVLPERPKSMWLGTSITPDAKKALRVRRREGTV
>CYP559E1 Mycosphaerella fijiensis
45% to CYP559D1
Mycosphaerella graminicola
estExt_Genewise1.C_70615
MELITDHPVVAIAFVVWILTALGSLTSRSRTKLPDIPWMGKSGNWPGAEYLATWSALASMRRWYSEGYKKYGK
QGQAYIL
PDVLGGKHVVLPNEKLGWILEQPDSVLSTGAAHYDALAGDYAFTDSQILKDLYHEHVVHQNMARKVGEVIPRTWQGICDA
FDELWGKDTQQWKTINIMDSMTHLVASVSNYFFVGEPLCRDKQFLRAGRAFADAVISCLFFNQLLPNIAKPFLMPIIAIP
NHWHHWKIARAVLPFFRKRMIEMEEAESKPGSTIEIPEDYITWHIRTAKKEGRLDMLQPYKVTRSLMAIEFAANHTTLLT
ISAALIDLFGSDPKLGYVEGLREEAERVYREHDGVWSKQAVNKLVRADSALRESMRLLNITYAVTRKVLAPEGVRTPDGM
LVPYGQYISVAAEERHYDADVYENPHVYDAFRFSRSREAYEAANPEDKNSQEYLKHQSKSFVTTSQDFLPFGHGRHACPG
RFFIQQELKMLFAYMLMNYDVQHLPERPPNFVWGPIHTPPPKTTLQVRRKERTL*
>CYP559F1 Mycosphaerella fijiensis
45% to CYP559D1 Mycosphaerella graminicola
41% to CYP559E1 Mycosphaerella fijiensis
estExt_fgenesh1_pg.C_130046 revised at N-term
MAGSTIENVVDQLDGASWWLIAALCLVCYTTYSAFTSNAIVPRDLPW
(2)
VGRKGRGPFSEIRAAIQCLLHQREFLAEGYHR (0)
YLSKGKSYVFPTLNGVSEVIIPSNKLPWLLDHPDSKASNVEAHF
DMLAGQYAFTDPKLLHHPFHEEVIHRNLGRKLANLIPPTWDEVKFQVDNTLGRNTEQWKEIHVLEAMTDIAAAISNRMIV
GLPLCRNAKFRDLQARFAAGVMFVVMLVQLSPKLMQPIVGHLASIPNRLVVWQCKKMTLPVIEKRLADIEHEGKNSEEKG
HTDIPDDYLTWQIRLAKERGDAKEYDADWITRRLMPLEFAAIHTSSFTIANILLDLLGSDPKLGYIEAIREEAETVYREA
NGQWTKQDLARMVKTDSAIRESMRVSGFGVRGVQRKVIDKNGLKDEEGWTAPYGSLIATDVWTRHHDPAIYPDPYRYDAF
RFSRAREQ
EDYLKSQSLSLISTSDRFLAFGHGRHACPGRFFINLEMKLLLAYLVMNYDFQYLQKRPENTITGEVIMPPMK
AGISFRRRPNSLFAAL*
>CYP560A1 N.
crassa AABX01000445.1 cont3.580 NCU09274.1 32% to CYP503
22936
MNTLHNISSPPGPLDPYANPFHLAIKDRIEHLSYPKTFALILITSWFLST
TAKWLTNGKRKKLAIPTWGYRSWFEPTLLLQARFVMGARQLVHEAYTK
(0) 23229
23290
MPNMPFVLKRYDADFLILPIRYLDELRLIPLSKLSNKGANVA (0) 23415
23484 NLVPEYHGIT
FLLTNNLHVEVLRKKLTPELWKFIDLASTELSHGWDISLPHSQLSANGND
WVKIDFERTVRDLVSRMTAKVFLGNPACRDETWLGISVAFSIDLFTASFT
MKMFPPWMYPVVAPLIPARRRVLKQLKAARGIVGEQMRKHASLKEKRAQA
ARGEVSLTAEEAQDTLLNWMLDHGKGDEVRVEEMSARQCVLTLASIHTTA
SQAANMMFDLCEHPQWWGVLQEEVDEIAKELGPPGLAGGMKEGGGGVSVK
EWCVRLEKLDSFFQETQRREPPIM
(1) 24335
24430
LGPQRLAQQDVTLKDGTFIPRGTRVA
FPMLEHQMDPQTYENPNEYDPMRFYRKRHESPDQMHLHMAGQTHPNVLGF
GYGNQACPGRQFAVAEIKLIMARMLYEFEFKFADEKKGRPKTGYINEMAM
TDWNARLLMRKRVR*
24852
>CYP561A1 Magnaporthe grisea MG00301.4 39% to 65B1 AACU01001402 cont2.70
MSIPQALGLGVLLVLGYLASVAIYRLYFHPLAKLPGPRLYAITSLPFLVR
DKILGTWVMSTTELHAKYGRMVRFAPDRVSVDGSIGWSDIYQRRPNLPEF
DKDIRTYQVGRLGLLPALRDDHRRQRRTVARAFSVTALKEQETYVQTHLD
FFIGRMHEFAAKDADVDISNWLNYLTFDIVGDLALGEPFGCMANGGYHPF
VSMIFDTAKANAMGNFMDNFKFLSPLVKLMGKKELRRNMAIIEMAAATTE
KRIALGPDARKDFMTYLLRKSKDGEGLTHPEILTNSRVLIVAGSETTATA
LCGLIFYLSRTPQAYRRLVEEIRSFTSEDQITMQTLEGLPYLNACLEEIL
RIYPPAADTPPRISPGAEVGGYYIPEGTVVSIYQWATHHNPDNFVNPLTF
APERWLPRSNPFYESIYDKDNKAAFRPFAVGPRDCVGKNLAYSEMRLVIS
RLLWNFDVTLVPGQDDWMKRQKVFLLIEKDDLFVKLKPVKRS*
>CYP561B1 Magnaporthe grisea MG09637.4
probable polyketide synthase AACU01001669 cont2.1850
MLKLSYLGVILAVAYISYLLGLAIYRLWFHPLAKFPGPAWLAVSEFPYL
FMGSYRGTFAARTLDLHRRYGKIVRIAPDRLIVDGSVGWNDVFAHRPGGD
ATEFHKAKGTYASPDGTALINATSRESHRRQRRALAHAFSEAALAEQEQL
IIRYVDLCMRRLSEASRGGSQPVDMMSWLNFLTFDIIGDLAFGESFGSLE
KGGYHFWVKNIFAAFKGTSRRRFFRRTGLSLLARLDPEKTVEKLTANNRY
SHEK
AWNGELDAQGRPVMKSRRDFMSYMMRKSGTDQ
GMTREEILNNTVTLILAGSETTGTNLSTFFFQLCLPQNRAIKDAVVAEVR
SKFTGEADVNFRSVQGNALPLLHACLEESLRIHPPVAETPPRVSPGAVVD
GRFVPRGTIVMVYQNATYRNPDNFVEPDAFRPQRFLPPSHPMYDARLAAG
SNTAAFKPFSYGPRDCLGKNLAYAEMNLVASRVLLRFDVELAENTPKDWL
DSQLSFGVWQKDDLMIKLGERRDVELKP*
>CYP561C1 Magnaporthe grisea MG00059.4 37%
to several families AACU01001358 cont2.16
MAASAFSPENILLGFAGKSTMGRVTYAMQLVGIGVAIYWIILATYRLYFH
PLAKFPGPRIRAITGMPYLYQSYVEGTFARKVRALHAEYGNVVRVAPNRL
AVDGVVGWKDVHAVRAPSPEMPKLPGYYGPDSHRSLVASPTREGHQRHRR
ALAYGFSNTAMHEQEPVITYYVDMLIRQLSKRSKEGPLDMAMWFNFLSFD
VVGDLAFADSFNILKKGKYHPWTSNLIKGIEGATLNRFFLFSSPLLAPLA
LLDLNGTIKTFWENRRIADSKTKARIDLGPDPPVQTDLIGRDGKPVVRKD
FVGYMLRFNQKASNEALSEVEMKRNANIIMNAGSETTATALAVLTFMFSL
PENRIWMERATEEVRATFKSEDEINLHSVSNHPLPILRACSEEALRFHPP
APDMPPRLCPGGTVGDYYVPKGAIIQISQLATYHNPDHFLECDDFRPQRF
LPPDHPLYEKRFANDNFSVFKPFSYGNRDCMGKNLAYIEMRFVMCRILFR
FDYLGLDYKGGATDQWLNEHRAFIVWKKPPLMVIFREREGLVPLEPPEDT
DD*
>CYP561C2 Magnaporthe grisea MG03825.4 poor
match 53% to MG00059.4 AACU01001030 cont2.747
MGSIAKEPLSSLDLLAAKGVLERLPTLGNWLLVGTIVYYVGLAIYRLHFH
PLAKFPGPTLSAVSGIPWLWESYITGTFTWNVRKLHEKYGKIVRISPNRL
AVDGSVGWSDIYSRSGGSEFSKYPGFFGPNGDLTIVGAMTKESHRRYRRA
LAHAFSETVMHEQEPLITYYVDLFIRRLSDASRDGASFNMVNWLNYVTFD
IVGDLSFAHSFNSLENRKGHPWIENMTTGILGGAYNRFLVEFPLAFPAVF
FHIRKAVNAFWTNRAYADEKSRARIAKGSADEVTDMVGSDGKPVVRKDFI
GYMLRENKDKEALTEVEIVRNAETLMNAGSETTATCLAALTYLLSLPENR
DWLNHVTNEVRNYFKREADVTLRSVNPKALPILNACIEESLRYHPPASET
TPRVSPGALVNGHYIAKGCVVQIYQLATHHNPENFLECDSFRPQRFLPPT
HPLYERRFANDNMASFRPFAYGSRDCIGKNLAYSEMRLVMARTLLRFDFV
GVDPVSKDFLTSQRAFTVWVKPSLWVKFKERTDLELKA*
>CYP561C3 Magnaporthe grisea MG02329.4 poor match 54% to MG00059.4
AACU01000455 cont2.461
MGISTPENVVPLTGTVTKGLLERLSGLGSVLAGGLIVYYIGLAVYRLYFH
PLAKFPGPPLHAISSMPFNIQSYLQGIFTWKVQGLHAKYGKIVRIGPNRL
AVEGSIGWTDVYGHRPGGTETEFAKLQGFFGPVPDHGIIAAPNREEHRRH
RRALAHAFSDTAMHEQEPLITYYVDLLIRRISEETRTGVPSDMLKWFNYV
SFDIIGDLSLAESFNALQTAKGHPWITNMFKGIKGGNYNRFLRLTFPMLL
PIAVFFDPTGAIKAFWENRLYSETKCKARLAKGADEDQTDMIGSDGKPVV
RRDFIGYMMRENRDKEKLTEQEIIRNSNILISAGSETTATCMGALSYLFT
LPENRQWRDAAVNEVRTHFKKEADIQLNTVGANVLPILHACIEEALRIHP
PASETPPRVSPGAFVGGEYVPKDTIVQVFQLATYHNPDNFVEADKFRPQR
FLPPSHPLYEPRFAKDNMAAFKPFSNGPRDCIGKNLAYTEMRLIMSRVFL
RFDFESLLPESENWLTRQRAFTIWEKAPLMIKLKERTDLEVKA*
>CYP561D1 Fusarium graminearum FG01740.1
AACM01000092 FGcontig1.92_scaffold1
MELPSFSLKFDHEKLLPLAIISTGLLVTSLVAISIYRIWFHPLAIFPGPK
WLAISNVPERYMSNISGTWIWRVSSLHRKYGPIVRIGPNRLAVDGSIGWF
QVYAMRGKEDEFPKYPEYIFPGDGLSILGANQVNHRRHRRQFWSAFNDQA
LVEQEIVIQPYTDMLLQRLSEQAKIGKPINIVDWINFLLFDIAGELVFSS
PFDCLDKQEYHPWVANFFRAVKGNAVNRFVTHYPITKPIVNFLFTGKEQI
QREADQRNMTFHHAMQRMKLGEQPTPGRRDFMSFLMRRNRDGGGLSDTEI
LVDCPVLIGASSETTTTALSGFFFYLGISPQAYKRLVEEVRSSFRSESEI
NMKTTKQLEYLNATVDEALRVYPPAAESPPRISPGAEIDGKYLPKGVVVS
VYQWGTFHNPDNFADPDEFIPERWLQPSHPLHNPKYDNDNRSVYRPFGFG
MRDCLGKNLAHAEIRVVVSRILYRFDYELAPNQENWHANQKCFMAWDKTP
LILTLKPRDFAP*
>CYP561D2P Fusarium oxysporum
pseudogene 51% to CYP561D1 Fusarium
graminearum, & = frameshift
FOXG_13060
LIVAIPAVIIYRLYFHPLAEVPGRKIHAITGFLTQWKSHILGTWL*EAAQLHRQY
GPIVRIGPNHIAVDGSIGWPQVHGHQPGKAEFSTYPNFIFPGDGMSLIGAQKDDHRRQRR
*LAHAFSDAALVEQQSVTLQYIDLLIKQLTQRAESGEPIDIVTWVNLTTFDIIGDLTFSE
SFGGLKSGGYHPWVQNFFDNIRGEGMMRLMDRYLLLKPLILAIGYRHI*ESMESAEMSMG
KAKARVALGEQPFEGRRDFVTYMLRRGKDGVTAMSETELLVNSSIVIGAGSETTATALSG
AFFYIGTHPQVYCYLVDEIRGAFTDASDITLKSTAQLQYLHACIEETLRIYPPAAETPPR
VCPGATIGGKYIPKG (0)
TVVTVYQWATFRNPSNFADPDSFRPER*LSQ &
THALDDEKYAGDNRAVFKPFSYGARDCIGRNLAYAELRVILSHILFQ
(0)
FDFELKPGQSDWHEKQTSFLVWDKDPLNITLKLRQDEASIS*
>CYP561E1 Fusarium oxysporum
39% to CYP561C3
FOXG_17449
MLLLDFIIMFRPLFDSWPLSALWL (0)
LIIYRVTIIVYRLCFHPLAKFPGPKYLSVSSLPFRYCSHIQGLFFKTVEQLHAKHGPVVRIAPDSL
SIDGLYAWESIYTHKSSGLPEWSKVPGHFFP (2)
GDHNVLINAPRETHRRQRRAIAPAFSNVALNDMETDILRHIQELLRALASKASNTQENSAESIDIMS
WLYLLTMDTVSDLIFSNSFNGLKDRMQQKFLLGFFDSTQGLQIGSFLMAYPLLMPFLPLI
YMADVGGLKSSHKYGSFIEAKAKTRMTTGLHSGARRDFIVYMTQDREDAAMETSEKKGMN
DLEISQNSLILATAGSDSTTTTMCGVLYYLAQPAAAKAKRAVLDELRSAFQSEEEVTLRN
TTSTSLPYLNACIEEAMRVYPSTAEQPPRVSPGELVGGHFIPKG
(0)
TKVYTYQWSTHRNPAHFAQAKEFHPERFLPESHQQYDKRFLDDRLSLVKPF
SHGPRDCVGRNLAYALMRLTLVNFLLRFDYELAEPKEDWLANQTVKFSWTKGPLRIRVRE
RNEAR*
>CYP562A1 Magnaporthe grisea MG05390.4 poor match 41% to MG10954.4
AACU01000502 cont2.991
MSGRTTDRRACARRRVIIPPASGAGVCRGHVDQSSAPWHPHVNHRVRVSV
LYKACPARPSPIFVSGHSDSLYTDGTCLVYAFYRVVYNVFFHPLRQYPGP
WHRGASRLPYTISIFRGDVTFRVKALHDKYGKVVRITPDTLSYTDSQAWS
DVYSLKKTGSSGNLPKDPKFYVAAPDTSTANDADHRRLRRVQAHAFSEKA
LTMQESFIQQHTDRYIKCLERAAQEADGVVDVVKWVNFLTTDLIGDLSFG
ETFGGLASGRLHPWLESVFTTLKTFTFIREFLRLPSWATRLAVACIPKHM
LEHQRSAVAFGADAARARIERGSDKPDFMHYILRHEKDDEKGRDLHGRHH
IHRRRERDYSPVAATMISGTVYLLLQHPDVLHRLVSVIRTDFPAIDDMNL
VNLQQHEYLNAVIKEGLRLYPPAADFLFRTSGGQSVVVAGRVVPPKTSLT
MNLWAMYRDPTNFHRPLEFIPDRWLKDAPAEFDKDDRACFKPFSVGPRDC
IGKNLAYAEMRLILAKMAWSLDLLSVEPDSQGWIEKQKIFGLWEKPPLNV
KLAPRVR*
>CYP563A1 Magnaporthe grisea MG07593.4 37% to 65A1
AACU01000919 cont2.1406
MSASVSIHSLGKNAPTIIAIAALATIATIAQFLWKRRSHPLRSIPGPWIN
SLSEIPAALALVKGDQHIYYKSLHEKYGRVVRVSPNELSFLSTEARQEIY
GLRKGGLNMEKSPIFLGAVGAVGGETGVSLALNADHTRQRRALGYLFTNS
ALLRFEALMKLQVQKFIAVMEEKTLKKEPVNVANWFTYLAFDIMGDLCFA
EPFGCLDQAANTEWSTSVINVFVSATWTQGIRRLSGTGTWLESLMTWLLV
PAKAAEWRRTHLNNSRERTLRRLASSEQDHADFIYHILNSEGKSTLSHNE
VILNVALMISAGTDTTATALTGWTYFVCTHPEVYQRLIDEVRGGLPTEDH
IRWENVRKMSYLEATIHEALRLYPPSPASQQRVVPRGGATIDGYFVPEGT
TVAVPPWVSTHSEMHFYDPESFRPERWLGEDDKYARDDFNASLPFGTGPR
VCIGRNLAYMEMQLITATLLWNYDLELDREKYLDVNSVWGLDGNMKRMKV
FHSMTKPDLWVKLNKVRQ*
>CYP563A2 Botrytis cinerea = Botryotinia
fuckeliana
GenEMBL AJ851088
join(852..944,995..1157,1224..1300,1351..1597,1658..2661)
aba2 gene
(note: CYP527D1 = aba1 gene)
57% to 563A1
in the CYP53 clan part A
MLLSIKDLSEKYIMLLDVKDLSTLKTTVAVLVTVALIAQVLWKI
FFHPLSAFPGPWFNRISEIPGSWVIATGKQHSYYRKLHEKYGPVVRVAPNELSFIGDR
AWDDIYGVQKKGPNFEKSPIFIGAVSPLDGQTGISLAPNEAHTRQRRALAHVFSNTAL
LQQEEIMRSHVDKLVGQLKKTIAENRPINFSNWYTYTTFDMMGDLCFAEPFGCLDQGG
ATEWSTSVINVFKSAAWDQSIRRVAGVNTWLQKLMVKLLIPSKAANWRKVHFQNSREK
TLRRLADGNREHKDFIYHILKNKEAKNSLSETEIILNMVLLISAGTETTASLLTGWTY
FICTHPEVYKRLTDEIRGRFNSEQDITWETVKDLPYLHATLSEALRLYSPAPANQQRI
VPPGGSVIDGHFVPGKTTVAVAPWAAINSSLNFKDPQKFIPERWLGDERFVNDKLNAS
QPFSLGPRGCIGKNLSFFEMRLITSRLLWNFDVSLVTTGEHGETNKLWDMDGAGKYMK
VYQTWNKPDMWVMLKEVPR
>CYP563B1 old name = CYP65N1 Magnaporthe
grisea AACU01000984 cont2.1481 MG07982.4 C-TERM EXON
AACU01000985 cont2.1482 N-TERM PART (3/4) RUNS
OFF END
MYGTNLLETMGKPTAGHLGMA (0)
ILVAFTIHVLRMRFFHPLRRYPGPWLNSITQIPAAWALLRARQPKAYRELHEKY
(1?)
GPIVRVAPNELSFINVEAWDDIYG
XXXNFEKSPVFIGAVSPLNGQTGISLANX
NEEHTRQRRALAAPFTNRALLQQQDILRVHVDKLITALRAKARNKESVNMGEWCMYL
TYTTFDIIGDICFAEPFGCLDGGESNEWARAIINIFKAATWDQAIRRVAGTGTLLHKALV
KIIIPAEAAQWRTIHFSNSKAKTLARLADPDRQHPDLIKHILDSEDSRAALSPTEIILNM
VLFISAGSETTANTMTGWTYFMLRHPEARARATAEVRAAFASPRDIKWED
(SEQ GAP HERE)
MGK (0) NLAYFELRLVLAHLLWHFDLEPTDSAAGRECMRRWEQTDMD
TYQTWMKPDLVDVYTQ
>CYP563C1 Mgr027 Mycosphaerella graminicola
50% to CYP563A2 Botrytis
cinerea, 45% to 563B1 Magnaporthe grisea
MNEGMPSTLTLATASGLIATFFIFILCRTIFHPLRSFPGPWLNATTELPSALRLAKGQQHIYYHRLHQEYGPVLRTAPNELTFTSDQAWNDIYGLKNGVVLEKSPIFIGIASPMNGCVGVGLAKGKEHTRQRRALAPGLSKTALYKQEEIIQRHVSALLDLLRENVERDEPSNIAEYFSFTTFDAIGDLSFSEPFGCLEQNKTTEWASAMRQVVIFASYDQAIRRVAGVDTWLRDLLLKVCMPAKAAHWRMLHVKKSLEKTAQRLEKPDSEKQDMIYHLLREKDPKKSLNHDEIKLNMMLYISAGSETTSITLTAWAYLIGTHPEAYRQLTDEICSSISSSADIKVDNVMSLPYLGATINEAMRLFPPGAVAMQRMVPPGGVTIDGHYVPGGTTVSVAPWAASRSPDNFHEPDNFRPERWLQALDQYQSKEFANDRLGASRPFGYGPKRCIGEDLSYLEARLIISHLLFTFDMELVDGHSPGAEANLRWGLRADSESIQLYQVLMKPDLWVRLSKRNNVS
>CYP563D1 Mgr080 Mycosphaerella graminicola
42% to CYP563C1
Mgr027, 42% to 563A2
MGLLYATGVVLVLLTFAWLVRRRRRDGLRHIPGPWINTVSPFAFPYQVVKGFANVYLYALHEKYGPVVRIGPNEVSFAGPALEAIYGLRKGGALEKSRAWLGGVSPWKGFHGLGIARGDEHRRQRRALAPSMSKAALKSQEGIIQENVGQLMDRLRAEAAKSEDVNVAEWFTYFTFDMMGDVCLNQSFGCLDLGERTDWADSIIDLHISSSWLTVIQQIAGMETRFGRLLSKVLARLFVPRQLDKSRKLHFQKTMDATVRRMEAESSHPDAIYHILRSNKEDRIIAPREEIILNMTLFLSAGSETTSILLTTCSWLLISHRQVLDRVVREVRSKFQHISEVTLDTVTDAHLPYLHAVIHEAFRLFPPAGTGVGREVPPQGDTITGVYVPGGTTVRVAAWTVQRSAEHFHQPDTFQPERWLKPPPKEFENDRLELSQPFIIGPRQCLGAPLVMFESQLALSRLLLQFDISAPVTRRGIAENEKWNLSPTIRSIESYTVIKKPNTWVNLRPVPGMI
>CYP564A1 Magnaporthe grisea MG07550.4 40% to 65B1 AACU01000913 cont2.1400
MIIPTSWREALLYLGLGVVAIFACNAVYNVFFHPLRHFPGPKSHAMSRIP
YTYHWVRGDLVRHITALHREHGDIVRLAPDELSFGDPQAWGDIMGGGSRD
LQKWNGVFDIPNFLPTHVQNTTDKSRHRMLRKAMGPGFSDAALRAQEHIV
ASHVDQFIQKLRGRRGVVDLEVWYRFIVFDVIGDLAFGESFGCANGAEFH
PYIRQICETAVMISYLMAINMYPILRNVVNFLIDGVARRGFDAQAQTLMP
ALERRIKLQEQRLDLVDPLIGKMNEWKWTINDLIPHAIMIVGAGSETTAG
VLCGTTALLLEHPEAMARVTEEVRSAFSSDGEINLERVDSRLPYLRACID
EAMRLYPVPGCASLRITGDRDIICGVPMPPKTVVGLWPYAVYRDPKLWRN
PDEFHPERWLGDPEYINDARKAFNPFHIGSRDCVGRGLAVMELRLIMARM
IYNFDMHLMGAGMKEDSRSWVDRQKNFFIVWERVPLEVVLTPTKS*
>CYP565A1 Magnaporthe grisea MG07497.4 poor match 51% to MG03433.4
AACU01000908 cont2.1394
MISLVYITIGFVLYRIARIVYNLYLHPLAKVPGPKLYAASWFPRLWRQHH
KGCHHTDLVQLHEKYGPIVRVGPDEVSNSSAAAWDAIGGGSQQFMRDPHF
FIVSQLQTTGSKSFISLEKSEHHSIRKLMMPAFSNKTYLLHESLVNSWLG
KLTSHIAAKNGAELNIERMFVWFTFDVMGALSFGENFGCLDQEKDHQYLR
AAELGAPCLSIMQILLRFPATQGLYDVARKLPWMRLWNSLREMSDDSASR
WLETVHDEKRTDIMATVYRGMQNTKDPISRHEALDVASILVLSGAEATPI
LMTAMLWNLLSNPRCYERLCRDVRESGIINGPADFTAANVEKIPYMEAVM
LEALRLDTPFATTIPRIVPEGGAWVDGYWLPGGTSCGIPHYTAGHWAQNF
SDPDTFVPERWMASERPAKYESDKRGVFRPFSKGSLDCIGQRFVRHEVGM
AFVALLWNFDFELSDRSLDWKTANGAEHIRIIRKKRPLWVKAIPRNVPSA
V*
>CYP565B1 Magnaporthe grisea MG03433.4 poor match 51% to MG07497.4
AACU01000709 cont2.676
MALTFYMLLGIFVCYRIYRIIYNLYLHPLASVPGPKIYAASWIPRLWRQQ
VLGVHWKDLVALHEKYGPIVRTGPDEVSNASKQSWEDICGSRVFNRDLNF
LRVTQLSERGGFISPVKQEHRIVRRLLQPAFTDRTIDRHADILYEWVTKL
RLNVAAHGGEPVDVAQKLVWMTFDTMGVLSFGESFGCLDGNRQHPYLRAI
ELGAPFLSALQVVLRYRATSSLYGLLLRLPLMRFWNSLRATAEAKAARWL
DKADSSRGDVMSLIWAAMQDTANPLSAGQANDLASILCLAGAESTPVLMA
GMVWWVLSTPHAHARLAAEVRAAFAHASEIQVSNLSRLAYLDACIMEALR
QHTPFTVAIPRIVPEGGATVDGHFLPAGTVCGVPHWASAHLPTNFANPDA
FVPERWLPDPPAPYDQDKRDTFKPFAKGSMDCIGKRLVYHEVRMVMATLF
WHFDMSLCEQSVDWVAGANATTATWRPISTVFH*
>CYP566A1 Magnaporthe grisea MG01947.4 poor match. first exon is best guess
AACU01000379.1 cont2.368 revised 7/18/07
NZ_AACU02000388.1
MSFLYESSRDYTSL (0)
1605 IILLATILFAYNYWFHPIAHINGPFWAKATP
FWLMSSVSGHRHNNDIEALHAKY (1)
GPVVRVGPNELSFATEDALKAIHNPPPGQPMFTK
KGTIESLLASLIWSAPNLLSTHDKATHKRLRNALQPAFTAKALLEQEGIS
QYHIDKEVEKMLSVGSKDPKSVLNLSEEVAGMIWDIVGDLSFGEPLQRHQ
RDKYEHLKITYATGAPFLELCQFLTEIPIIGRLATLPIILTPFIYRKPRH
FLLINKLKQWIDDHDGGRKDFLTAIMSARETANLTHEEMLSNAALFVMVG
CDTTAATISALFYLLLKHPSSMARLTAELRTAFPRKGDVTATATLKLPYL
GAVIQETLRLLPPINGRGSHRISPGALVDGIYVPAGVMVSADPWSIGRSP
RYWAEPHAFRPERWVPGEQDEGPWRTDVRSAWRPFMVGPRVCIGREMALQ
SIRLMVSKTLVEMDLEMVNKDFVWERDAANDYVWYNFDILVKCKPRVRG*
>CYP566B1 Fusarium graminearum FG04590.1
AACM01000193 FGcontig1.193_scaffold2
AACM02000109.1 47% to 566A1 revised 7/18/07
MEDLLDQVVVELHRARSCLSDPLVFTQAAVIG (0)
SILFVFLLGLYNYFLHPIAHIKGPFLAAVTP (0)
ISLIRSVAGHRLNNDIKALHHKY (1)
GHVVRIAPNELSFSSERALRDIHNPGPDNHHYTKRGTSEDLILRFVFGA
NNILLVDEGEDHKRLRGALQPAFTAKAMRDQQDITHYHVQKTVERLLEAA
MDPSQTISLTKELNKLVWGNVGNLAFGEPATLEQLENHEKAKDLHAQIAP
ILEFFQYLNGNPILGRAARGLVGISRKVFGLSGNILGKDQLRRHIASQQG
QKNFLTAILGAKESSGLSFDEIHSNMLLLLMGGYDSSAASLSAIFYHLLR
EPQQYKRLQSELHHAYSSVNDITCNSLLSQPMLNACINESLRLVPPFNGH
GSHRVTTSGTMIDGVWVPAGTLISADFYSLHRDPSCWAFPDEYRPERWLK
EHQGPGTPFENDVKTAWRPFSLGPRVCVGREMALQSIRLAVSKIVYTFDM
TLANRDFVWDRDAGSHYMWHDFDIAVTLAKA*
>CYP566C1 Aspergillus nidulans AN2610.1 38%
to 566A1 53 clan
revised 7/18/07 NW_101284.1, 79% to 566C2 Neosartorya fischeri, 79% to 566C2
MTLIESSPAQFTLVACSL (0)
GVAFLVLIVVYSYFFHPLARVPGPWTGAVFP (0)
309588 FWSISTLYRRRLNPDLAELHKIY (1) 309535
309472
GPVVRVGPNQLSFATIEAQKMIYNAKPTNNGSDEH
FGRDGTLQDVLLSMILGAPNIGSLSNRAEHKKMRK
RLLPGFTSNTIFEQEPLLRLHVDQLLHRLAQDAGLINLTSHFSRFLWDLI
GDFSFGEPLVPEKH (1)
ELRTDKLKSMVEIYQGCFPLLEAINHVVPEINAVIRLAFRLVPPATLRAVLPTATLRG
(2)
CVDRQDGRSDFLTHIMGDKSRDPTELEL
SYDEVHSNATVLM (2)
IAGYKTTETSLSALFYRILSTPGVLKNLQSELFSNFQ
SIDGITGRKLLSLPYLNGCIYESLRLAPPVAGKFASRRSPGAVIQGFYVP
PGTEVFTETYTMQRSPLYWYAPDEYHPERWLKQSEGSPYAQDVHEAFKPF
SSGPRACLGREMALQTLRLTTALLAYRFDMEMVNEDQFVWEQDTESRMVY
SQYQIKAVVQEHLT*
>CYP566C2 Aspergillus fumigatus Af293
GenEMBL
XP_750865.1 also EAL88827.1 NZ_AAHF01000006.1
89% to 566C2 Neosartorya fischeri, 79% to 566C1
revised 7/18/07
MGAQQFKAMSAISPEQVAIMACSL (0)
GTGLLVSVVIYNYFFHPLARVPGPWTGAIFP
(0)
FWTMSSLYRRTLNPDLAELHKRY (1)
GPIVRVGPNQLSFATVEAQKMIYNAKPTHTGSDELFGREG
TLQDVLLSMILGAANIGSLSNRAEHKKMRKRLQPGFTSKALFEQESLLRLHMDRLLERLAQDTGVIDLT
EYFSTFLWDLIGDLSFGEPLVREKH (1) 1072139
1072086
AALHTDTLRSLVALYQGCFPILEAINYAVPQIEGVLRLAMQLVPTATLRAVLPSATFRD (2) 1071910
1071773 CIDRQDGRSDFITHITGDKSRNPTELELSYEELHSNATVIL
(2) 1071651
IAGYKTTETSLSALFYRLLSTPGVLKKLQSELFRNFPSIDEITGKKLLSLPYLNGCVNES
LRLTPPVAGKFASRRSPGAIIEGFYVPKGTEVFTETYTMQRSPQYWHAPDEYRPERWVERGEGSPYAQDV
HEAFKPFSSGPRACLGREMALQTLRLTTALLVYRFHMKIVDEKRFVWEQDTDSRMIYSQYQIKAILQDRLT*1070978
>CYP566C2 Neosartorya fischeri NRRL 181 revised 7/18/07
NZ_AAKE03000024.1, XM_001258096, 89% to 566C2 = ortholog, 79% to 566C1
NFIA_055490 revised, removed two intronic seqs
Name revised from CYP566C3
189543
MDAQHLMTMSGISLEQVAIMGCSL (0)
189469
GTGLLVSMIIYNYFFHPLARVPGPCTGAIFP (0)
FWSMSSLYRRRLNPDLAELHKKY
(1) 189182
189121 GPIVRVGPNQLSFATVEAQKMIYNAKP
THTGSDELFGRDGTLQDVLLSMILGAANIGSLSNRAEHKKMRKRLQPGFTSKALFEQESL
LRMHMDRLLQGLAQDTGVIDLTEYFSRFLWDLIGDLSFGEPLVPEKH (1) 188720
188664 GRRTDTLRSLVGVYQGCFPILEAINYAVPQIEGVLKLALQLVPPATLRAVLPSATFRD
(2) 188491
CINRQDGRSDFLTHIMGDK 188299
188298
SSNPTELELSYDELHSNATVLM (2)
IAGYKTTETSLSALFY 188119
188118
RLLSTPGVLEKLQTELFSNFQSIDEITGKKLLSLPYLNGCVNESLRLTPAVAGKFASRRS 187939
187938 PGAIIEGFYVPSGTEVYTETYTMQRSPQYWHAPDEYRPERWFERGEGSPYAQDVHEAFKP 187759
187758
FSSGPRACLGREMALQTLRLTAALLVYRFHLKIVNEDRFVWEQDTDSRMIYSKYHIKAIV 187579
187578 QERLT* 187561
>CYP567A1 Magnaporthe grisea MG03819.4 poor match defective KYG seq motif
like CYP65s possible pseudogene? AACU01001030
cont2.747
MFHLFSDHVHWLGPLGVAVFFGTLAARCIYFLYFHPLAKYPGPRLAAVSY
LWYARKWLQGRYPWAIEELFETHSSEIVRVGPNGIAFRSPQAMHDIYMAT
VRNRETFVKTEFQDLGGKEPGITAERDPEEHRKVAKQLVPAFSPRAMLAQ
EQHVHRYVDLLVQQLDKHGGTSSKGVDMREWFDWLVLDIAGYMAWCHEFD
NLKNAETCFYLRESIKIGLSGTVGQVLRKFPLLLPLAPFFIPASVARTIP
TWMQFNRDIVAERLSKQEKLDGKDYFAWLLRDGSKPPSEDWLVAQSNVLL
AAGFDPLTNILTAAVHYLCKTPRALERLCAEVRGEFSTYSEIRADKLQSQ
KYLQAVLDESMRIHTNAAFGLPRYSPGALVDGEYIPKGVIVQNASFATTH
SPKYFLLPREFWPERYLGPDDRWYDQRFEHDHKKAFKPFSIGPRACPGRE
IGMMQARITLAKLVWTYDMELLNPEVDWDKESKLFLIWGRPEVRVRFRKR
VI*
>CYP567B1 Fusarium graminearum FG10695.1
AACM01000446 FGcontig1.446_scaffold7
MAATLIVFGGLLLLAWLVNIAYRSLFHPLAKFPGPKLAAVSDIWYAIKWT
SGRYPFIMEETHRKYGDVVRIAPNELSFATVQAYQDIYGHALKGKKKFVK
SNWYDTAGDHPGIVSVRDPKEHSRQRKYLSHAFSAKSLRGQEVLVHGYVN
LFLDQLR
KLGSSEGEGINIEEALNWLTFDIIG
DLAFGESFDAVANGKTHFWVSIIIDATYTSMLSALRKRVPLVN
LYLPFVVPKDAKATYQKHRALTREKMLKRLDMPNSEDRGDFFASLLRKGG
NEVPEPELLQQSNTLIVAGSETTATCLTGIVFCLLSNPSCLEALSNEVRS
RFQSDSEITGDATADMKYLSAVIEEGLRIFPPAPFGLPRISPGAVIDGHY
VPPGVTVSVDHWTTKHDRRYWKDPYSFIPERWIDEGFGDTKQASQPFSLG
PRACLGINLAYLEMRIIIAKMVYCFDWEL
PRLMVRFHPHN*
>CYP567B2 Fusarium oxysporum
85% to CYP567B1, yellow is possible intron but
it makes the seq too short
This seq is missing in F. graminearum
FOXG_10874
MTASLSILGVFCASLSFTMLYIIYRVLFHPLAKFPGPKLAAVSDIWYALKWTSGRYPFIMEETHRKYGDVVRIAPNELSF
ATVQAYHDIYGHALKDKKRFIKGSWYDVAGDHPGIVSVRDPVQHSRQRKYLSHAFSAKSLRGQETLIHGYVDLFLGQLR
NLGSPGGAGINVEEALNWLTFDIIG (1)
DLAFGESFSAVAEGRSHFWVSLIIDASYAMMLSGLRKRVPLVNLYLPFVVPKDASAMHRKHMALTREKMLKRLEMPNSEDR
GDFFSHLLRKGGNKVPEPELCQQSNTLIVAGSETTA
TCLTGIVFCLLSNLSCLEALSNEVRSRFQSDTEITGDATADLKY
LSAVIEEGLRIFPPAPFGLPRVSPGAIIDGHYIPPGVVVSVDHWTTKHDGRYWKDPHAFIPERWIDGGFGDTKQASQPFS
LGPRACLGINLAYLEMRIIIAKMVYHFDWEL
VNNEVDLFRDSKLYLLWKK
PRLLVRFHPHN*
>CYP567B2 Fusarium verticillioides
81% to CYP567B2 Fusarium oxysporum probable
ortholog
FVEG_12172
MAASFSIILGLSCLL (0)
GVIWFLNAIYRLFFHPLAKFPGPKLAAVSD (0)
LWYGLKWTSGRYPFIMEETHRKY (1)
GDVVRIAPNELSFATVQAYKDIYGHATKDKKKFIKGDWYETAGDHPGIVSVRDPAQHSRQRKYLSHAF
SAKSLRGQETVIHRYVDMFIGQLRKLGSPEGSGINVEEALNWLTFDIIG
DLAFGESFSAVAEGRPHFWVSMIIDAAYFKALSALRKRLPIINLYLPFVMSKDAGEMH
RKHMELTRQKMMKRLQMPNSEERGDFFSHLLSKGGNDVPEQELCQQSNTLIVAGSETTA
TCLTGIVYCLLSNRSCLEKLTDEVRSRFHSEDEITADATAELKYLPAVIEEGLRIFPPAPFGLPRISPGAVIDGHY
ISSGVVVSVDPWTTKHDGRYWKEPYSFIPERWIHESFSDVKQASQPFSLGPRSCLGINLAYLEMRIILAKMVYNFDWELVNNDVDLFRDAKLFLLWKKPA
LMVRFYPRT*
>CYP567C1 Aspergillus nidulans AN1737.1 47%
to 567B1 53 clan
MALESILSLPAATLAAGVAALVAMYWLASYAYLYWFHPLSKYPGPPLAAV
SELWYASAWTGGLWNRKIEEAHRRYGDIVRIAPNELSFATAQAFRDIYGA
PSKTRKLFPKSDRFYDNGHPNIAFVLDPEEHARQHKIFAPQFRPSAVRTQ
EPIVHAHVDFWVAQIAARGRSGAVPVDVSKWFEWLTFDIIGELTFGQSFN
ATRDNKSHPWVSILLDATYSGSIFNLRKRLAFVGPLLRWMPYISSTARAA
VESVSQHGAMTLAFTRKRIESGPARNDVDDFLAHAIRAGGMTDTELADQA
MVLLTAGAETSATALTATLWYLSQPAHAHCLERLRTEVRGAFASPADVTG
DATARLPYLNAVLEETMRLFPPSPVGPPRISPAGGETVDGTFVPGGVYVS
ADVWTIHHDARTVGARPDAFEPERWCDGQKPYTVPFSIGPRMCIGVTLAW
VEMRIALAKAVLAFDWELAEDAVGGSGDWVEEARLKQLWQKPPLMMRFRP
LEAKA*
>CYP567D1 Aspergillus nidulans AN3281.1 41%
to 567B1 53 clan
revised 7/19/07 89% to A. clavatus CYP567D3
MSASWVDEPSSLLGIFEVVFVL (0)
KRHPNGSELQTLVYVSTRILYNIYFHPLAAFPGPLLARASM (0)
AWRIYHSMGGRFHRAIDEQHRRY (1)
GPVFRVSPNELSFASVASWKDIYGHRAT
GKPPLIKSKFYEIYGAGFGSLCIGSERDPEKHTRMKKSLSPAFSLRSLGD
QEVIVSQCVDRFVSRMGEPELNAGGLNMTKWYEMVAFDILGEL
(1)
AFGESFHSIED (1)
GKPHFWSSLIEDHLYFITVADNFRHFPVVALIAKLLSPFLDSIRKKHTGYTRNKVAQ
(2)
RIRSSSPRKDFMANLIGKVESNEMSREELTAHASTLV (2)
IAGGETVATFLAATTFYLLRDD
AVYQKLKAEIRGQFNTYEEITCATAQNLPYLQAVISEGLRIYPPGSQGFP
RISPGASIDGIWIPAG (0)
AEVYTSAWTVTHDEANFHDPHTFKPERWIDPDCADIKEASQPFSLGPRACLGRN
(2)
VAYMEINLILARLIWTYDMELVNKSMDWESESSLHVMWSKPELKVRFRQARP*
>CYP567D2 Aspergillus oryzae
GenEMBL
BAE64652.1, AP007171.1
99% to CYP567D2 Aspergillus flavus, 61% to 567D1
14 P450
genes and 2 pseudogenes on this contig
MDRVVWLGLAVA (0)
286366 LTALYWVHLVIYNVFFHPLASFPGPFWARASF (0)
IWRMWHTSTGRVHRAIEFQHNLH (1)
GDIVRISPNELSFASVESWKAIYQPKSAPLVKSEFYEIYGSGFNSLCIGSE
RNPETHSRMRKSLAAAFSTKALLEQEDIIQGCVNDFIEGIRSQTTVNFTKWFEMLAFDILGEMAFGESFHCIEN
(1)
SKSHFWCDMIEEHLYFITILDNLRRYPLIAAIGKTILPHLTVSVRNKHTNYSRRKVA
HRLQSSSPRADFMSRLIAKVEDEEMEMEELTAHASTLV
IAGGETVATFLAAVTYHLLSTPN
AYQKLRDEIRARYNHLSEITSTTALQLPYLQAVISEGLRIYPPGSQGFPRNTPPQGIVVKGTYVPGNVEV
YTSAWTVTHDARYFHDPYTFKPERWLDPNCTDNKDASQPFSLGPRGCLGRN
FAIVEMSLILCKLHFQFDAELVNPFQEWESASQLHVMWWKPDLPVRFIPCTRDH
>CYP567D2 Aspergillus flavus
AFL2G_04896, this model has a C-term extension
that is probably wrong.
Model revised
MDRVVWLGLAVA(0)
LTALYWIHLAIYNVFFHPLASFPGPFWARASF (0)
IWRMWHTSTGRVHRAIEFQHKLH (1)
GDIVRISPNELSFASVESWKAIYQPKSAPLVKSEFYEIYGSGFNSLCIGSERNPETHSRMRKSLAAAFS
TKALLEQEDIIQGCVNDFIEGIRSQTTVNVTKWFEMLAFDILGEMAFGESFHCIEN
(1)
SKSHFWCDMIEEHLYFITILDNLRRYPLIAA
IGKTILPHLTVSVRNKHTNYSRR
KVAHRLQSSSPRADFMSRLIAKVEDEEMEMEELTAHASTLV
IAGGETVATFLAAVTYHLLSTPNAYQKLRDEIRARYNHLSEITSTTALQL
PYLQAVISEGLRIYPPGSQGFPRNTPPQGIVVKGTYVPGN
VEVYTSAWTVTHDARYFHDPYTFKPERWLDPNCTDNKDASQPFSLGPRGCLGRN
FAIVEMSLILCKLHFQFDAELVNPFQEWESASQLHVMWWKPDLPVRFIPCTRDH*
>CYP567D3
Aspergillus clavatus NRRL 1
XM_001273850.1 89% to A. nidulans CYP567D1
ACLA_063960
MSASWGYEPTSWLDIFTVVFVL
(0)
ERHANGTELQILVYVSTQSLYNIYFHPLAGFPGPLVARASL
(0)
AWRIYHSMGGRFHRAIDEQHRRYGPVFRVSPNELSFASVASWKDIYCHRATGQLPLIKSKFYDIY
GAGFGSLCIGSERDPDKHTRMKKSLSPAFSLRSLGDQEAILSQCVDRFVSRMGEPELN
AGGLNMTKWYEMVAFDILGELSFGESFHSIEDGKPHFWSSLVKDHLYFITVADNLRHF
PVVALIAKLLSPFLNGIRKKHTGYTRDKAARRIGSSSARKDFMANLIGKLESNEMDRE
ELTAHASTLVIAGGETVATFLAATTFYLLRNDAAYQNLKAEIRGQFNTYAEITSARAQ
ALPYLQAVISEGLRIYPPGSQGFPRVSPGASIDGIWVPAGAEVYTSAWTVTHNEANFH
DPHTFKPERWIDPDCADIKEASQPFSLGTQACLGRNVAYMEINLILARLIWMYDMETV
NKSMDWESESSLHVMWSKPDLKVHFRQARP
>CYP567E1 Aspergillus nidulans AN3275.1
Missing N-term 147aa 53 clan
revised 7/19/07
MVPYGTCETMDHFRGQPALVLIGASALVGIITWIARLLIRAFVSHPLAHFPGPRLSALSN
(0)
LNYSWSYMGGRQPYDILNLHAEY
(1)
GSVVRVAPNELSFNTAQSWKDIYAPRKGRATFIKSDFYDGGNFADQASSI
VSERDPARHSAMRKFLSAAFSDRSLREQEGLVTRVIDDFIDQVGQRGNSKDGVDMTMWTNL
LTFDIIGEL (1)
AVVLESMGQAGLSDFLKRFPIIGRVFLKLNPRWLNKLMDGAIKHQTYTIDLVKR
(2)
RIQQKTNRKDFMSYLLLERNSSQISDIQLAAHASDFV (2)
ATLKEDHSIAGSETTATCLATVIYYVGRNPRILKTLQEEVRSAFRNYEEI
NGQSTSSLKYLHAVCLEALRIFPPLALALPRVVPEGGEMIDGHFVPEK
(0)
TIVSTNPLAASMDPANFDTPWAFCPERWIRLSEKDQLEASQPFSMGSRSCLGRG
(2)
LAWLELRLTLAKLYYRYDLKLVDDELDWHRDAAMHLLWVKPKLMTQVLPRAK*
>CYP567E2 Aspergillus clavatus NRRL 1
XM_001273844.1
ACLA_063900
1
MDQFKGQPAWVLIGVSGLMGIMIWIARLLIQAFVSHPLAHFPGPRLSALSNLNYSWAYMG 180
181
GRQPYDILNLHAKYGPVVRVAPNELSFNTPQSWKDIYAPRKGRPTFIKSDFYDGGNFADQ 360
361
ASSVVSERDPAKHRAMRKFLAAAFSERSLREQEGLVTQVIDDFIDQVGQRGNSKEGVDMT 540
541 MWTNLLTFDIIGQL (1)
AFGESFHGLETGNLHFWIAVVTESMGQAGLSDFLKRFPIIGHIFLK
720
721
LNPRWLNKLMDGAIKHQTYTIDLVKRRIQQKTNRKDFMSHLLAERNASQISDIQLAAHAS 900
901 DFVIAGSETTATCLATVIYYVGRNPRILKALQEEVRSAFGRPEEINGQSTSS 1056
1057
LKYLHAVCLEALRIFPPLALGLPRVVPEGGEMIDGYFVPAKTIVSTNPFAASLDPANFDA 1236
1237
PWVFCPERWLRLSAEDQLEASQPFSMGSRSCLGQGLAWLELRLTLAKLYYWYDLKLVDDE 1416
1417
LEWHGDVAMHLLWVKPKLMTQVTPRAK*
1500
>CYP567E3 Penicillium citrinum
BD294642 PAT 04-NOV-2005
DNAs
related to the biosynthesis of ML-236B (compactin)
MEGFGSFLGIAMPLLVAFILKLGIWRVYFDQLSKFPGPGLSALTNVPYSMSYLSGRQPWE
MLSLHKKYGSVVRVSPTELSFSTAQSWRDIYGTQRGRAGFIKSSFYDGGNFADKAHSIVS
ERDPEKHSAMRRFLSTAFSDRSLREQEGLITSTIDKFVQKVGEVGSHPQGVDLTNWFNLL
TFDIIGDLAFGESFGGSLYIGKTHPWISVVLESMGQASLSDTIQRFPWMGRLYMRLNPEW
ARRLIAGSIKHESNTMDLVKRRIASKSPRSDFMSYLLRERSEFDQEVSDTQLAAHASDFV
IAGSETTATTLLVVAYYLSRYPEITRKLQKEVRSAFDSYEEINGSSTARLRYLHVICLEA
MRMVPPLPLGLPRVVPKGGAMVDGHFVIVSTNPLAASLDPKNFENPWTFDPDRWLQDGKE
QFGEASQPFSLGSRSCLGRSLAWLEMRVTLAKLHFSYDFTPVNENIDLQQDLRMHLLWKK
PELRFRVSPRK
>CYP567E4 Podospora anserina DSM 980
NW_001914833
XM_001903508.1
join(290518..290576,290629..290705,290761..291144,
291257..291437,291504..291975)
P450
adjacent to terpene cyclase
49% to 567E1
MSTSIPFPSSLVPCTAPLVTQQIPHCLWFLGGRQPYKILELHNR
YGPVVRTAPNDLSFNTAQSWKDIYGSRQGHQAFVKSAFYDGGSFASRGVGSIVSERNV
DAHAQMRRYLSHAFSDRSLAEQEDIIARTMDIWVESLLKKGSRKEGIEMGKSFRIMTF
DIIGELAFGENFK (1)
ALNQGALADTLKRFPTLAWLAQGLLQKKIWELT
EDTKKNENFAIDMINRRIHRDELSRKDFMTHILQRRGSAQVSDLQLAAHASDFALAGS
ETTGTALSAIMYYLLRTPQVMLKLQKEIRGSFKTYSEICFRSTIGLPYLDAVILEGLR
MYPPVPLGLPRVVPDGGDTVDGHFLPAGS
VVVYTHPVAASLSSANFKDPQAFKPDRWLDEHQGDIREASQ (0)
PFSLGTRACMGRKY (0)
MRTALAKVLWKYDLELVNTSLDWHRDSEMHTLWCKPALW
VRLRVLKE*
>CYP567F1 Nectria haematococca
fgenesh1_pg.scaffold_19000024
Necha1/scaffold_19:59238-60876
47% to 567B1, same gene as e_gw1.19.165.1,
gw1.19.162.1
This gene model seems correct
MTISRAVLLLGISGSAV (0)
LVFWFLALVIYRLFFHPLAKYPGPKLAACTE (0)
LWFVRSWAGGYHPFVMRQVHEKYGDVVRVAPNELSFRSLAAHKDIYSQTPKGKAPFLKSKVFYNVGPSIK
HPDIVFTRDPEDHRVQRKALSHAFNSKGLRDAEETIQEHTKLFVEQIGKHAGPGTKGVDVTAVYNWLTFDVI
(1)
GVLTFGESFESVSRWQSSGW
VTLLLNMAKHMTFLPVAERLSVPPFALGAVMPSDVSKNAAYHDKLTEEKINRRIGLIKSNDREDFFAFIL
REGNFDPVHLREQAKVLMLAGSETTATFLAMVTYFLLKNPVTMKNLQHEVRSAFSSAGEITGDSTNNLSY
LQAVIEEGLRMLPPSPIGLPRVCPGATIDGHFVPAGTDVSVDAYVLGRDDRYFPEPDEFRPERWIGDDTG
NEKDASRPFSFGPRACLGINLAYLEARIVLAHMVYAYDWEL (0)
PELYVRFHPRDV*
>CYP567F2 Fusarium oxysporum
59% to 567F1
FOXG_09562
MIAFNRKYERHNSEV (0)
FASWIIGVIIYRLYFHPLAKFPGPKIAACSE (0)
FWFLRSWASGYYVQNIGDLHRKYGDVVRTASNELSFRSPVALRDIYNHVSKDRPTFLKS
DTLYTVDPSVTRPDIVFTRDPQDHRLQRRSLAHAF
SAKALRDNEESVQFHVKLLLERLGQ
NAGPGTGGANMSEVFNWLTFDVI (1)
GDLTFGESFDSLNQWRPSEWVTWLLGFISSLTFLPFINRFKIPMTLVVSVMPSYLKEKID
IHTTEKIKKRIGMGNSRDREDFFAYILRKESDNLDLVHLREQAKVLMIAGSETTANL
LAATTYYLLKNPDKLANLQAEVRSAFSARDEITGDAVAHLPYLNGVIEEGLRIFPPIPFG
PPRVCTGATIDGHHVPKGVVVSVDGFATTHDERNFIRPDEFLPERWIGEGFGDRKEASKP
FSLGPRGCLGINLAYMEARVTMASLVWKYDWEFVNQDLDWLADVRLHLLW
EKPKLMVRYHPRDEVATT*
>CYP567F2 Fusarium verticillioides
92% to CYP567F2 Fusarium oxysporum = ortholog
FVEG_14083 revised
MILFNRKFERHNSEV
FVSWIIGVIIYRLYFHPLAKFPGPKIAACSE
FWFLRSWASGRYINYMGDLHRKYGDVVRTATNELSFRSPVALRDIYNHVSKDRPTFLKSD
TFYTVDPSIPRPDIVFTRDPQDHRLQRRSLAHAFSAKALRDNEESVQFHVKLLLERLGQN
AGPGTAGANMSEVFNWLTFDVI (1)
GDLTFGESFDSLNQWRPSEWVTWILGFISSLTFLPFINRFRISMTLAVSVMPSYLKQKIDMHT
TEKVKKRVAMGNSRDREDFFAYILRKESHNLDLVHLREQAKVLMIAGSETTANLLAATTYYLLKNPDKLANLQAEVRSVFSSRDEITGDAVAHLPYLNGV
IEEGLRIFPPVPFGPPRVCPGATIAGHYVPKGVVVSVDGFATTHDERNFIRPDEFLPERWIGKGFGDRKEASKPFSLGPRGCLGINLAYMEARVTMASLA
WKYDWELASQDLDWLASVRLHLIWQKPKLTVRYHPRDEVAAT*
>CYP567F3 Fusarium oxysporum
59% to CYP576F1
FOXG_17536
MNFLSTLAALWVALSLTM (0)
ILVGLSGLCLYRLFYHPLAKFPGPKLAACSQ (0)
FWFLRAWTGGKYPFVMRELHDRYGDVVRIAPNELSFKTPQAYKDIYNHAVGHKTPFPKSKY
FYNRGASIKHPDIVFTIDRESHRSQRRSLSHAFSARALREAESTIQRHARLFVHQISQRG
NPGTGGVDMSAAFTWLTFDII (1)
GDLTFGESFESVANWEPDTYVALILEFIKHFTIIQAAKRLGISEGLLSLFIPGDLKDS
MAFHESLTKEKVARRIKLGDFNQRRDFFAHILRDGGFNRDHLAEQAKILLLDGSETTATFLAGVTYLLLKSPTALSKLQC
EVRSSFASLDEIRGDSLNQLPYLRAAIEEGLRLFPPVPLGLPRTCPGAMIDGWYVPSGTEVSVDNFVMSHDAKSFPEPDEFR
PERWLEGQTGNNKEASRPFSIGPRACLGVNLAYLEASLILATMAYSFDWELVDKSLHWFE
EVELMSFWNKPQLFIRYHPRGSFHGA*
>CYP567G1 Phaeosphaeria nodorum SN15
XM_001795181.1
102355-104120
45% to
CYP567E1
102355 MMITALSWFSAYSVQTL
102406
SLCALIVFVANKVWKHLRHPLREFPGPRLAAWTDIPYCYWLLGGRQPFVLLQLHEKYGP 582
583
VVRIAPNELSFNTAASWKDIYGYRPGHRTFVKGEFYDGAAFVKSHATRSLINTKDPTEHG 762
763 KMRRYLANAFSDKSLREQESLVAQEVDKLVEKLGEAGLAKDGTDLQRWLNMATFDITGSLSF
(1) 945
EQTTDDPQMARHPTV
AFILRAILTLSFVDTVRRFPWLDT
VARIAMPGRIK (1)
AQLHHASTKRQ
1267 LTVPERRIDKPSNRPDILTRIIDKKDEAGISDIQIAAHAADLL (2)
TMLTFHRTAGSDS 1446
1447 TNTAMGTVFYYLLKRSDIMQRLQAEIRSSVESYNEITALSTNNLPFLIAVIREAMRIYPP
1626
1627 VPLALPRIVPEGGDTIDGRFVPAG (0)
TGVSTHPFAACLDAKNFEDP 1806
1807 WIFRPERWLGKSEQNVREASQPFSLGTRGCIGQ 1905
1959 LAWIEMRTIVAKVIYAYDLKWLNPVMDWHRESQMHILWHKPQLMVRVVARQRT*
104120
>CYP568A1 Magnaporthe grisea MG07507.4 poor match AACU01000909 cont2.1395
MTVLELPSERLASPPIAVLTAALIVLAVVFKAVYNIFFHPLRSYPGPLLW
GASRFPYVVRFMQGKIPYDLKRLHAEYGPVVRIAPDELTYNCSKAWRDIY
GRNKQPNGETTLFNKDPILYSAVFADHKALIDSDGDEHRPQKRTLSYAFS
HQVLVERGHIITGCIDRMIEGVKAHLGSSPSVSAVVDICPWIENALFDLG
GQLTVGRDLNAIMSQGTVHPSLALFKSLFDLVQCYYLQLRRGPGILINAV
ESMPGFSGYDCVLPVKDVHDMILKRMADEKYAVADENSGDFASYLMSRAK
SEGLNDDKVWINCVHLILGTPEAMPSSIISTIYHLLTTPYAYAEAVREVR
AAFKSSDEITAQDVQNLPYLLACFRETLRRRPTIPGTLTRQCGKFVQGGT
IVGVNQFATSRSASNFHDADSYRPERWLDPRPAEFEGDDRDAFNPFGYGP
RKCIARNLAHLTTQTFLAKLLWEFDMELDESCRDWDDQGLYVLALRGPLL
VKLSRAAQ*
>CYP569A1 # name changed to CYP531B1
no sequence
>CYP570A1 Magnaporthe grisea MG03392.4 40% to CYP527A1 39% to 527C1
AACU01000700 cont2.665
MLNMSFSAGSSSSCAMLATAAIWGISAVVAYAVFARFRDWRRLKHIDGPS
LAGWTDYWMIRSQLSGRMNLDLADVVREYGPVARIGTNTIVCADVKELRK
IWAVRSTWKRPRWYLGLRIDPYSDNVFSLMDDKVHETLRSKLMPGYGGKD
VDGVHEIIDEQISLFVRLLEDKYLSVDGKDSEGKSFLPVDLARKVQFLTL
DIISSLAFGESFGNLVADDDALGYISTTEKSMPMLMFVTLVPWLTAVWQS
PRLRWAFPDARKMVGIGDVMAIARRVVGERYGEKPEVVKRDMLGSFVAHG
LTKGEAESETMVQIVAGSDTSATAIRSTLLFIITNPAVYSRLQAEIDAAA
AEGRISSPITDAEARALPYLQAVIREGLRMYPPATGLLPKVSSKDEILCG
KHIPAGTDVGWAVWPVMRDRGVFGDDADLFRPERWVEAAPEQWRVMDQTV
MMDFATGSRWECLGKTIAMIELNKAYVELLRRFDITLLDPSNPWHSFNAA
FFIQKNMNVKISRRKTPV*
>CYP570B1 Magnaporthe grisea MG01544.4 40% to 527C1, 40% to 535A1 AACU01000068
cont2.284
MSRIHQFSTVVPVSVHKGTVFILFGTIAALLLAHSIYKSWSRLRHIPGPP
GTGLSKWWMFRNAMGGSMHLALKEAVDKYGSLARIGPNTLVTNDPDVLRK
LWAVRSPYKKSDFYQAVRFDPVRDNLISMRDDDEHSVLRNKMAAGYAGKG
NEGLENVIDKGISAFIGLIERNYVSDETAFRPMDLARKVQYASLDIIGLL
GLGERFGFTDEDTDVHQYIKILEESMTSMIILTIFPTMAKLLQSRLFRRL
MPSERDKIGFGVFIGVAKQFVTDRLASANPYRRDMLGSFLAHGLTREEAQ
GELLLQIVAGSDTTATAIRMTMLYVMSSHVVYERLVAEIRRWAADSLAAT
GNASVPATDSEARGLPYLQAVIKEGMRMHPPVAGLMGVVVPPGGDVLCGI
NVPEGTEVGWSAFSLQKREDIYGFDAACFRPERWLEADQESLRTMNATWD
LIFKYGKWQCLGKPVALIELNKLFVELLRRYDFALVDAASALKSDFAGIF
LQSELMVKVTRAQ*
>CYP570C1 Fusarium graminearum revised
AACM01000122.1 added C-term gc boundary after YVE
MAVAALINYLRDLRPSIAIAASLVLFLAAWTALSTWRQYIRLRQFKGPTL
AAFSKWWLVKKVGGGRAYLDFWEVTQKYGTIARVGPNDLLTDDPDLMKHI
LNVRTEYRRSDWYDGMRFNPGNNNILSHRDEDEHFKLRSKMSAGYGGREV
ENLEPKIDKNILSFISLLAKYAEAKKPMDLGRRAQFFTLDVISDLAFGEP
FGFLETDSDVYKYIQITEETLPAVMVTTVIPWLVKILSSPLFKSLLPSEK
DRLGFGKLMGIAKKVTAERFGPDKKVRKDMLGSFVAHGLTQKEAESEILL
QIVAGSDTTATAIRSTMLHIITNPNVYSKLRAEIAGTHYSEPIIPDSIGR
DLPYLQAVIKEGLRIFPPVAGLMSKQVPPQGDTWKGQFIPGGTKVGYCAW
GIFRREDIWGSDAGEFRPERWLESDPEKLKEME
GALELIFSYGRWQCLGRPVALMELNKIYVE (0)
LLRRFDFSICDPTKPWKVFNCGIFSQSELMVRVTER
>CYP570C2 Fusarium graminearum FG02929.1
AACM01000143 FGcontig1.143_scaffold2
MGFIQLDSRGFALVGLLVFVAYVVATLRQWARLRHFKGPALAGFSQLWLI
SCVGGGRTHLDLWEACKKYGDIARVGPNDLITSDPDLMKHMLNVRTLFQR
SNWYDAMRLDPTKDNVLSQRNDDLHASTRSKMVGAYSGKEVDNVETTVDT
NVERLIDLLDTKYIAKNKAFDFGYKAQYFTLDVISSLAFGEQFGDLETDS
DVNGYIKAMEESMPTIIVTTVMPWMMKLLQLPVFKSMLPSEKDKVGVGRV
MAIAKRVTADRFGPNPKEHRDMIGSFIARGLLQHEVESEILMQILAGADT
TATAIRATVLYILSTPRVIEKMRAEIDQARPSLPVITDSEARAMPYLQAV
VKEGLRIHPPVVGLMSKEVPAGGDTFKGKYLPGGTKIGYCAWGIFRRRDI
WGEDADEFRPERWLESSEEQLHLMEGTLELVFGYGRWQCLGKTIAQMELN
KVFVEQVFIIASPAELVV*
>CYP570C3 Nectria haematococca
e_gw1.7.150.1
Necha1/scaffold_7:1454491-1456289
86% to 570C1
This gene model seems correct
MSSVDGLRGLFDGVRPSIAIAGLLVGVLIFWSGISTWRQYNRLRAFKGPRLAGFSKWWLIRTVGS
(1)
GRAYLDFWEVTKKYGSIARVSPNDLLTDDPDLMKHILNVRTEYRRSPWYDGMRFDPANNNILSWRDEDEHFKLRSKMSAG
(0)
YGGREVENLEPKIDKNILAFIKLLRKYADEKKPVDLGRRAQFFTLDVLSDLAFGEPFGFLETDSD
VYEYIKTTEETLPMVMVTTVVPWLVKVLSSPIFKSLLPSEKDRLGFGRVMG
(2)
IAKAITAERFGPDKKVRKDMLGSFVAHGLTQKEAESEILLQI (2)
IAGSDTTATAIRSTMLHIITSPHVYNKLRTEISKTSYSEPIIPDSIG
RDLPYLQAVIKEGLRIFPPVAGLMSKEVPPQGDTWKGQFIPGGTSVGYCAWGIFRREDIWGPDAGEFRPE
RWIESPPEKIKEMESALDLIFSYGRWQCLGRPVALMELNKIYVE (0)
LLRQFEFSICDPTKPWKVFNCGIFSQSELWVRVEPRVTES*
>CYP570C4 Fusarium oxysporum
84% to CYP570C2
FOXG_14304 Supercontig 24: 19205-19551 (-) strand same seq
FOXG_14867 Supercontig_25: 302853-303199 (-)
strand
FOXG_14868 Supercontig 25: 303463-304548 (-)
strand
Supercontig_25 302737-304548, joined the two
models above
MSFLQQLPQIGLLQLAAVAGIIILICYVVSTIRQWARLRHFRGP
AIAGFTQLWLISKVGGGRTHLDLWEACKKY
(1)
GDIARVGPNDLITSDPDLMKHMLNVRTRFQRSSWYDAMRLDLTKDNVLS
QRNDELHASTRSKMAAAYSGKEVDNIEMTVDENVERLLELLDTKYIAKGRPFDFGYKAQY
FTLDVISALAFGEQFGDLETDSDVNGYITAMEESMPTIIVTTVMPWMIKLLQLPVFKSML
PSEKDKVGVGKVMAIAKRVSADRFGPNPKVQRDMIGSFIARGLLQHEVESEILMQM
(2)
LAGADTTATAIRATLLYVISTPRVVQAMRAEIDQAKPSLPIITDS
EARAMPYLQAVIKEGLRIHPPVVGLMSKEVPKGGDTFKGHHLPEGTKVGYCAWGIFRRPD
IWGEDSNEFRPERWLDCSQDQLRLMEGTLELVFGYGRWQCLGKNIALMELNKVFVE
(0)
LIRRFDLAVVEPIKPWQSINVGVFLQSEYWIRGYKRAGLS*
>CYP570C5P Fusarium oxysporum
Supercontig_23 457233-458956 (-) strand
Not found in Fungal genome database
One stop codon, possible pseudogene
MGLIHLDGRAAALVGVVFVLWYVVSTIRQWAHLRHFKGPAIAGFSQLWLISRVGGGRTYL
DLWETCKKY (1)
GDIVRVGPNDLI
TSDPDLMKHMLNVRTRYKRSSWYDAMRLDPTKDNVLSQRDDDLHASTRSKMAAAYSGKEV
DNIETTIDENVERLLDLLDTEYISKDIPFDFGYKAQYFTLDVISALAFGEAFGDLETDSD
VNGYITAMEESMPTIITTTVMPWMIKLLQLPIFRSMLPSDKDKAGVGRVMAIAKKVAAER
FGPNPKVQRDMIGSFVSRGLLQHEVESEILMQM (2)
LAGADTTATAIRATLLYIISNPRVVQAMRAEIDNSKLSHPIVTDAEARAMPYLQAVIKEG
L*IHPPVVGLMSKEVPQGGDTFKGQYLPEGTKIGYCAWGIFRRTDIWGEDSDEFRPERWL
HSSVDSLRLMEGTLELVFGYGRWQCLGKNIALMELNKVFVE (0)
LIRRFDLAVVDPIKPWLSINVGVFLQSEYWIKGYERASLA
>CYP570C5P Fusarium verticillioides
99% to CYP570C5 Fusarium oxysporum = ortholog, only 1 aa
diff
both species have stop codons in the same place, both are
in ther EXXR motif
FVEG_13512
MGLIHLDGRAAALVGVVFVLWYVVSTIRQWAHLRHFKGPAIAGFSQLWLISRVGGGRTYL
DLWETCKKY (1)
GDIVRVGPNDLI
TSDPDLMKHMLNVRTRYKRSSWYDAMRLDPTKDNVLSQRDDDLHASTRSKMAAA
YSGKEVDNIETTIDENVERLLDLLDTEYISKDIPFDFGYKAQYFTLDVISAL
AFGEAFGDLETDSDVNGYITAMEESMPTIITTTVMPWMIKLLQLPIFRSMLPSD
KDKAGVGRVMAIAKKVAAERFGPNPKVQRDMIGSFVSRGLLQHEVE
SEILMQILAGADTTATAIRATLLYIISNPRVVQAMRAEIDNSKLSHPIVTDAEAR
AMPYLQAVIKEGL*IHPPVVGLMSKEVPQGGDTFKGQYLPEGTKIGYCAWGIFRR
TDIWGEDSDEFRPERWLHSSVDSLRLMEGTLELVFGYGRWQCLGKNIALMELNKVFVE
(0)
LIRRFDLAVVDPIKPWLSINVGVFLQSEYWIKGYERASLA*
>CYP570C6 Fusarium oxysporum
Supercontig_2 5000713-5002479 (+) strand
Not found in Fungal genome database
MGFIQLDSRGFALVGLLVFVAYVVATLRQWARLRHFKGPALAGFSQLWLISCVGGGRTHL
DLWEACKKY (1)
GDIARVGPNDLITSDPDLMKHMLNVRTLFQRSNWYDAMRLDPTKDNVLSQRNDDLHASTR
SKMVGAYSGKEVDNVETTVDTNVERLIDLLDTKYIAKNKAFDFGYKAQYFTLDVISSLAF
GEQFGDLETDSDVNGYIKAMEESMPTIIVTTVMPWMMKLLQLPVFKSMLPSEKDKVGVGR
VMAIAKRVTADRFGPNPKEHRDMIGSFIARGLLQHEVESEILMQM
(2)
LAGADTTATAIRATVLYILSTPRVIEKMRAEIDQARPSLPVITDSEARAMPYLQAVV
KEGLRIHPPVVGLMSKEVPAGGDTFKGKYLPGGTKIGYCAWGIFRRRDIWGEDADEFRPE
RWLESSEEQLHLMEGTLELVFGYGRWQCLGKTIAQMELNKVFVE
(0)
LIRRFDLSVVNPIKPWHSINVGVFLQSEYWIRGYRRIN*
>CYP570C7 Fusarium oxysporum
Supercontig_13
88% to 570C1
FOXG_10682
MAAASLLHRLRDVFGDVRPSIAIAGLLVVFVTLWSALSTLRQYNRLREFKGPRLAALSKWWLIKKVGGGRAYLDFWEVTK
QYGSIARVGPNDLLTDDPELMRHILNVRTEYRRSDWYDGMRFDPGNNNILSWRDEDEHFKLRSK
MSAGYGGREVENLEPK
IDKNILSFMNLLGQYADEKKPVDFGRRAQFFTLDVISDLAFGEPFGFLETDSDVYKYIQITEETLPAVMVTTVIPWLVKV
LSSPLFKSLLPSEKDRLGFGKLMGIAKQVTAERFGPDKKVQKDMLGSFVAHGLTQKEAESEILLQIVAGSDTTATAIRST
MLHIITNPLVYSKLRAEITDTTFSEPIIPDSIARDLPYLQAVIKEGLRIFPPVAGLMSKQVPPQGDTWKGKFIPGGTKIG
YCAWGIFRREDIWGSDAGEFRPERWLESKGEKLREMENALELIFSYGRWQCLGRPVALMELNKVYVE
(0)
LLRRFDFAICDPTKPWTVFNCGIFSQSELMVRVHRRD*
>CYP570C7 Fusarium verticillioides
FVEG_09330
90% to CYP570C7 Fusarium oxysporum = ortholog
Note: possible mutation TGA to CGA at normal
stop codon extends gene
Also one frameshift = & in first exon,
possible pseudogene
MAEASFLDHMREIVGDVRPSIAIAGLVAIFVVLWSVLSTWQQYNRLREFKGPRLAA
LSKWWLIKKVGGGRAYLDFWE &
VTKQY (1)
GSIARVGPNDLLTDDPELIRHI
LNVRTEYRLSDWYDGMRFDPGNNNILPWRDEDEHFKLRSK
MSAGYRGREVEHLEPKIDKNILSFMKLLGKYADEKKPVDFGRRAQFFTLDVISDLAFGE
PLGFLETDSDVYKYIQITEEMLPAVMVTTIIPWLVKVLSSP
VFKSLLPSEKDRLGFEKLMGIAKQVTAERFGPDKKVQKDMLGSFIAHGLTQKEAESEILLQT
VAGSDTTATAIRLTMLHIITNPLVHPTLRAEISKTHFS
EPVIPDAIGRDLPYLQAVIKEGLRIFPPVAGLMSKQVPPPQGDTWKGKFIPDGTKIGYCAWG
IFRREDIWGSDAGEFRPERWLESKGEKLRERESALELI
FSYGRWQCLGRPVALMELNKVYVK ()
LLRRFNFTICDPTKPWTVFNCGIFSQSELMARVHRRD
RIVESHLITATETYTMDGPQWTRWIPVCTVIVYFQLRLLRSLCL*
>CYP570D1 Fusarium graminearum revised
AACM01000470.1
MSNTSGGSAGLLRDILQIVNHEPKIAIGAVVFCFVVIFIVNSFRAWYRLS
HVPGPFLGSFSRFWMLRGSIRTHLPEEMQAAVDKYGSLVRVGPNELITDD
VKLIKKIHSGRSAYTRGPWFESVRFEPGKDNLFSMRDEEGHKKLRNKMAA
GYSGKENPSLEGSVDSIIASFIALLETKYLSTDDVYRPVDFAQKSQFFTL
DVISDLAFGQPFGYLTKDEDVFDFLKITRAFFPFTVTMANVPWMISLLHS
RLFSGLLPKDTDKIGFGAFIGVAKEKVAERYAPGAAPHADMLGSFIKNGL
SQEQTSRESLLNVVAGSETTATTIRMIMLCILTNPLAYRRLQQEIDDAAQ
AGKISSPITDAEARRLPFLQATIQEGLRIKVPAAGPLYKEVPGEGDTING
MFIPGGTQIGISPFSVYLSKKVFGPDASVFRPERWLNAEPERLEVMAESV
GLVFSSGKWQCLGKPVAIMELNKIFVE (0)
LLRRFDFSIVKPEKPLDIFNAVSNCSLVAVCKLTR*
>CYP570D2P Nectria haematococca
gw1.28.270.1
Necha1/scaffold_28:406101-407808
Chr 14
MSAGQGLSPGLLREAFVALSPGTVILTAVIGLVVLFLADSLRT*YRLSHIPGPFWAGFSKA*MVRQSLKG
TQPYAIQAANKKY (1)
GSLVRIGPNELATDDPKLLRRMMASRSPYSRGP (1)
WYNALRFEPGKDNLFSMRDDNAHAKLRNKMAAG
(0)
YSGKENESLERTVDTHIARLIDLIETKYLSTSRDYRPTDFAQKIQYFTLDVISDLAFGQPF
GYVDQDDDVFDFIKITRSFFPVTLVIANIPSLVSLLHSRLFRGLLPKESDKFGFGAFIG (2)
VANKKVAERFA
PNATQHSDMLGSFIRHGLTQEEASRESLLNVVAGSDTSATTIRVIMLSLLSNPVAYRNLQKEIDDAIKAG
KISSPVTDAEARKLPYLQAAIQEGLRMKAPAAGPLFKTVPKQGDTIDGKFIPGGTQISTSPFSIYHSKKI
FGNDAALFVPERWLEAEPEQVEGMSEVVNLVFSSGKYQCLGKPVALIELNKIFVE (0)
LLRRFDFAMVHPERPLHIINAVSNAPSWLVL*
>CYP570D3
fgenesh1_pg.sca_33_chr6_1_0000031|Necha2
97% TO 570D2P W/O Stops
MSAGQGLSPGLLREAFVALSPGTVILTAVIGLVVLFLADSLRTWYRLSHVPGPFWAGFSKAWMVRQSLKGTQPYAIQAAN
EKYGSLVRIGPNELATDDPKLLRRMMASRSPYSRGPWYNALRFEPGKDNLFSMRDDDAHAKLRNKMAAGYSGKENESLER
TVDTHIARLVDLIETKYLSTSRDYRPTDFAQKIQYFTLDVISDLAFGQPFGYVDQDDDVFDFIKITRSFFPVT
LVIANIP
SLVSLLHSRLFRGLLPKESDKFGFGAFIG
VANKKVAERFAPNATQHSDMLGSFIRHGLTQEEASRESLLNVVAGSDTSAT
TIRVIMLSLLSNPVAYRNLQKEIDDAIKAGKISSPVTDAEARKLPYLQAAIQEGLRMKAPAAGPLFKTVPKQGDTIDGKF
IPGGTQIGTSPFSIYHSKKIFGNDAALFVPERWLEAEPEQVEGMSEVVNLVFSSGKYQCLGKPVALMELNKIFVELLRRF
DFAMVRPERPLHIMNA
GIWLIEDFPLRISRRDSSPDA*
>CYP570D4 Fusarium oxysporum
82% to CYP570D3
FOXG_14514 revised
MTLEGDPSAGFLRDVLQSVTDHPRAVIATAVLGLVVLFVADTLRTWYRLSHVPGPFWAGFSKAWMVRQSFKGIQPYAIQQ
ANEKYGSLVRIGPNELATDDPKLLKRMMSSRSAYTRGPWYNALRFEPGKDNLFSMRDDDAHAKLRNKMAAGYSGKENESL
ERTIDEHIAKLINLLETKYLSTDKDYRPVDFAQKIQFFTLDVISDLAFGQAFGYMEQDDDVFDFIKITKSYFPVT
LIMANIPSLVSLLHSKLFSGALPKESDKLGFGAFIG (2)
VANKK
VAERFAPGAQSHPDMLGSFIRHGLTQEQASRESLLNVVAGSDTSATTIRLIMLSLLSNPIMYLKLRNEIDDAIKAGSISS
PITDAEARKLPYLQAVIQEGLRIKAPAAGPLFKQVPPQGDEIDGKFIPGGTQIGQSPFAVYHSKEIFGQDASLFSPERWI
NADPAKYEAMAEVVSLVFSTGKYQCLGKPVAFIELNKIFVE (0)
LLRRFDFCMARPERPLHIMNAVSYLSMIDVAAANW*
>CYP570D4 Fusarium verticillioides
94% to CYP570D4 Fusarium oxysporum
FVEG_13355
MSGESDTSAGFLRDVWQAVAKHPRAVIATAVLGLVVLFVADTLRTWYRLSHVPGPFWA
GFSKAWMVRQSFKGIQPYAIQQANEKYGSLVRIGPNELATDD
PKLLKRMMSSRSAYTRGPWYNALRFEPGKDNLFSMRDDDAHAKLRNKMAAGYS
GKENESLERTIDEHIAKLIKLLEAKYLSTNQDYRPVDFAQKIQFFTL
DVISDLAFGQGFGYIEQDDDVFDFIKITKSYFPITLVMANIPSLVSLLH
SKLFSGALPKESDKLGFGAFIGVANKKVAERFAPGAESRPDMLGSFIRHGL
TQEEASRESLLNVVAGSDTSATTIRLIMLSLLSNPIMYLKLQKEIDDAV
KAGSISSPITDAEARKLPYLQAVIQEGLRIKAPAAGPLFKQVPPQGDEIDG
KFIPGGTQIGQSPFAVYHSKEIFGQDASLFSPERWINADPTQYEAMAEVV
SLVFSTGKYQCLGKPVAFIELNKIFVELLRRFDFCMTRPERPLHIMNAGI
WLIEDFPVRITRRGA*
>CYP570E1 Nectria haematococca
e_gw1.4.199.1
Necha1/scaffold_4:1300784-1302553
42% to 570D1, 39% to e_gw1.7.150.1
This gene model seems correct
MGLLADLSLTRLCLVAVSVVIAGLGTRQFRRWHRLRHIPGPRGAGWSTWWQLRGALSGHYHEHLKQAADQF
(1)
GPLVRIGPNELLSTDPDVLRNMSAVRSTYTKGDFYMSGRIVPEVDNVVSERNEVKHKAMKAKMTPG
(0)
YSGKENEGFGFEAGLDRQLLNFIALIDRKYASAPDETRPVDLAEKTQFFALDAIGDVSFGEPFGYLTQDEDLY
HYNEINASSLSAMDVVSVYPWLTKIVHRWPLKLLLPREGDQVGFGRLMG
(2)
FATQFVRGRLAEGATPDKDMMQAHINNGMNEEELIQQVFISI (2)
IAGSNSSAHALRMIILSIITNPPAHASLLAEIRQHVSSVNTPISWAQIQ
TLPYLQAVVREGLRMWPPLAGLGFKQVPPEGDTINGFFVPGGTQVGQGFHAVGRSRLVWGDDADMFRPER
WLLADESELKRMIAAWDTHFGHGKYVCLGKPIALMEIHKAVFE (0)
LIKRYDFAIMNPEKPISIQASVFLFASDFWVRITRRNDPDIEGTK*
>CYP570E2 Fusarium oxysporum
78% to CYP570E1 Nectria haematococca
FOXG_01097
MGFLTDQSLTKICFRVIIVLLIAQSFRLVRRWSRLRHIPGPASAGWTSWWQCRGAFSGRYHEHLKNAADQF
(1)
GPLVRIGPNEVLSTDPVVLRN
MSAVRSNYTKGDFYSSGRIVPGVDNVVSERDEAKHKFMRVKMAPGYSYKENEGFGFEAGIDRQLLNFISLIDRKYLSTTS
ESRPLDLAEKTQFFALDVIGDVSFGEPFGYLTKDEDLFQYNEINASSLPVMNVVSVYPWLGRVVHRWPLSLLLPREEDQV
GFGRLMGFARHFVRKRLAEGITMKKDMMQMHISNGMNEEELIQQAFISIIAGSNTTAHALRMIILSLITNPNAYRSLIAE
IRKVTSSVSNPISWAQTQTLPYLQAVVREGLRTWPPVAGLGFKQVPPEGDTINGFFVPGGTQVGQGFYAVGRSRLVWGED
ADVFRPERWLLAGEDRLRDMVAALDTHFGHGKYSCLGKPIALMEIHKAVFELFKRYDFAILNAERPIKTQTSVFLFASDF
WVTITQRDDEEN*
>CYP570E2 Fusarium verticillioides
93% to CYP570E2 Fusarium oxysporum = ortholog
FVEG_00415
MGFLTDQPLTKICLQVTLVLLVAQLFRVVRRWSRLRHIPGPASAGWTSWWQ
CRGALSGRYHEHLKNAADQFGPLVRIGPNEVLSTDPVVLRNMSAVRSTY
TKGDFYSSGRIVPGVDNVVSERDEAKHKFMRAKMAPGYSYKENEGFGFEAG
IDRQLLNFISLIDRKYLSTTSESRPLDLAEKTQFFALDVIGNVSFGEPF
GYLTKDEDLYQYNEINASSLPVLNLVSVYPWLGRVVHQWPLNLLLPREED
QVGFGRLMGFARHFVRKRLSEGVTTRKDMMQMHISNGMNEEELIQQAFIS
IIAGSNTTAHALRMIILSLITNPNAYRSLIAEIRKVASSVSNPISWAQTQ
TLPYLQAVVREGLRMWPPVAGLGFKQVPPEGDTVNGFFVPGGTQVGQGFY
AVGRSRLVWGDDADVFRPERWLLADEDRLRDMIAALDTHFGHGKYSCLGK
PIALMEIHKAVFELFKRYDFAIFNAERPIKTQTSVFLFASDFWITIIRRDDEEN*
>CYP570F1 Mgr016 Mycosphaerella graminicola
42% to CYP570C1, 41% to 570D1, 41% to 570B1, (borderline
member of CYP570)
MGLLEAALSLVTATNIILLIITAYVAQTYLASRSLAHIPGPFLSNYTTIPLLWKTYRGTLYHDIGELIAKHGPLVRIAPG
RVITGSAKTWAKITAARSPYLRSDWNDAMRFAPGQDNVLSMRDEKAHSDLRMKMAAGYSGKENPDLEKTIDGVVMQFVKL
IEEKYLSDAEHFKPMDLTEKFHFFTLDTITALAFGESFGDLKDDNDKYDYLKEIEKSITSIIMLADVPWLWNFLERTNLM
SLLLPGEELGLGKATKIAKDLVDARFEGSSDGKPTIDRMDMMGSFLRHSLTRQQVESETVLQLIAGSDTTATAISTVFLN
VLTSPPIYQKLMREIDETCIPGLAIGDAKARTMIYLQACIKESLRIAPPVSGVFPKLVPPGGETIDGYFVPEGTKIGWSS
KAVTQNPELYGPDASCFRPERWILQTHGGDCESVDKLLQMERDNAMIFGAGRFKCLGQAVAVLELNKIVVELLRRFEMRT
CDSKKPLAYEFNIGIWIQHGVWMRVTKRERYSG
>CYP570G1 Mgr065 Mycosphaerella graminicola
42% to 570C3, 39% to 570D3, 41% to 570A1, 39% to 527D1
The two families CYP570 and CYP527 may have some overlap
MVHTLLFAAFALFALIVARAARRHAALSHFGGHWSVGWSRLWLLRTQGSGQMNLRFTKINQQFGSTARIAPNMLITSDPD
LMRRMNAVRSPFTRGPWYAALKLHPDRDNITSYTDERKHADIRSRMAPGYAGRENPHLEQDVDDALIKMHSLIAEKYLNR
PENDQFRILDLARICTFFTLDVISKIAFGEPFGYLENDEDPYGYLANLAQLLPALIVFGVYSEFANLMKIPLLKASLPKS
TDKRGLGRVMGFAAARVRERFGTKPIVRRDMLGAFINKGLTQGELESETLTQIIAGSDSTASSLRLTLHFITTSPPILER
LLAEANAGIEAGRISRPVIKDQEARGLPYLQACIKEGLRMYPPVTGLLAKRVPDEGVHIDVDGVEKYIPGGVQIGWNSWA
MMRREEIFGKDVEMYRPERWLLRQGGGAAEVARAKRMTETVELCFGYGRFGCLGRGVATMELNKAVLETLLRFSLQPCSL
SKPFDEKVVGFYIHDNMNFIATERRTDSGRDVLELTSKAGDGADAAEASAIGGAYEE
>CYP570G2 Mycosphaerella fijiensis
71% to CYP570G1 Mycosphaerella
graminicola
estExt_Genewise1.C_260099
MVAAAFLPLFAIVLLLIARKIRQFYALNHFAGHWSSGWSRLWLLRTQSSGRMNKIFTELNNKYGSTARIGPGMLITTDPE
LMRRMNAVRSTFTRGPWYAALKLHPERENITSYIDERKHADIRSRMAPGYSGRENHHLEEEVDDRLMKMHTLINDKYLTR
PDEGVYKTLDLSRVTSFFTLDVISQIAFGQAFGFLDHDDDPFGYLKNLSEFLPAILVFGTYTELTNILQLPLLKAALPKN
TDKRGLGRVMGFAAERVRERFGSKPVVRRDMLGAFINKGLTQDELESETLTQITAGSDSTASSLRVTLHFISTSPPILHR
LLSEAKAGISAGKISRPIIKDSEARKWPYLQACIKEGLRMYPPVTGLLAKRVPDDGTVIEVDGVEKFAPGGTQIGWNSWG
MMRHQTIFGPDVEIFRPERWLPRDESELEKQRIQTMTETVSLCFGYGRFGCLGRGVATMELNKAIIETLLRFNLQPCSLA
KPFDESVVGFYVHENMNFVATERKDLGEGGGEVVFEGEVDAGAIAGAYEE*
>CYP570H1 Mgr068 Mycosphaerella graminicola
44% to CYP570C1 new N-term from JGI model
fgenesh1_pg.C_chr_1001460|Mycgr3
MDSVSGLNNSFGFTAIDARRHLNGIGVDVMRSDDILKITKQPFRALTVLLLSAILLSLVARVSRRYRHLAEYRGPGIAAY
TRLWICRTIASGNSAKI
MVDINKQYGPIARIGPNHLLTSDPELVKHILAARSHYTRGAWFDSIRIDPEVTNIVSERDTGRHNHLRHQMSGGYGGKEV
ENLERDVASRVMEFVSWLEERVTECGNGKQPIDLARPIQYLTIDIITHLCFGYPLGFVRENRDLFNFLQTIETQLPIVQH
FSVILELNTLLRTLVKVPFLRPFITPSARDKSGIGVIMGLSREVIDKRYAPGAPAERDMLGAFKKHGITADEAVTEVSIS
LVAGSDTTATSMRAILLMIISNPRVYGKLQQEIDDFAAKGMLNSPVADEQSRQMPYLQACIKEGLRRYPPITQLRERVSP
PEGDIFHGHRIPPGTFVGINAWGLQLDPVYGPDADVFRPERWLEAEPEQLVAMTQVHGLIFGYGNTKCLGIPIAMMNLNK
FFVEVLRRYDVALADATQPWKSLCYGIFFQKDFNVVISRREEAV
>CYP570J1 Histoplasma capsulatum G217B
48% to CYP570A1 Magnaporthe grisea
HCB00160.1
MRLLLLLVSSLAVAYLVVRRLQTWYRLRHIPGPRWCGWTDIWILWRAWTGSLYEDLGDLCQQHGPLVRVAPNYVVCGNPA
EVRRMWGVRSEWDRSPWYKGFQLDPPRDCTLSMRDNALHTVLRSKLAPGYSGKGIESLPESVDAQIAKFIRLIETKYLST
DTELRPVDIARKVQYLTLDVISTLAFGRTFGFLDEDGDLFDYIKTTEESLPLMQMIALLPWLVNVLQSRLFKAFLPSHTD
VVGVGKVMGIAKEVVSERYGDSKITKPDMLGSFVAHGLSQRDAEAESLVQIVAGSDTTATTLRISLLLLTTSPRTYATLV
SEIDTAISRGNISSPVTEAEARSLPYLQACIKECFRFWPPITGIMPRICPHEAEVCGVKVPGGTNVGWSARAVLRDKEVF
GEDAEVFSPARWLERADSKEGNRDGETERLGRMERTVELVFGQGKWGCLGKPISLLEINKVLVELFRRFDFAILNPAHPM
DTFNYGVSMQSGLFMKISRRTHI
>CYP570K1 Aspergillus clavatus
49% to CYP570C1 Fusarium graminearum, 47% to
CYP570D3 Nectria
ACLA_061370 revised
MILPSFKIGETSVSVQVLLVTLLGLSLVSLAQRFVAWRRLSHIPGPFLASFSNLW
LAWHAHRGTLPWAIKDVTDKY (1)
GPLARVGLNVAVNANPESVVKILQPRSGFIRALDYQAARFRPGSDNILSMRDEKAHKTLKLKTTAGYNGK
DVEGLEGQIDRVVESFVDLIERKYLSTPSDYRTVDLARITQYFTLDVIMSVAFGKNFGHLESDSDVYRYLSMTESFMPVV
AIVLVYPWLCNVLESKFLKMMAPKDTDKQGMGKVMGFAKEVVSERFGPNRIVRKDMLGSFIAHGMTQEEANSETLVQIVA
GSDTTATAIRAIFLHVISSPHIYSTLRKEIDNAGPISSPITKAEAENLFYLQAVIEEGLRFWPPIGLLASKLVPNGGATI
NGFFMPEGSNIGVSIMGIQRSKDIFGEDADEFRPERWLNIGEGEAEKAREKKMRGTVDLVFASGKYSCPGRQVAMMELNK
IFVEVLRKYDITLVNPSQPWTSFYAGVWMQKNLRVRFSKRTDSVIA*
>CYP570L1P Mycosphaerella fijiensis
40% to CYP570F1 Mycosphaerella
graminicola
e_gw1.17.140.1
frameshift = &
MSTSISLYSELLLIGVLGLATAFYLASWARSYRRLSHI &
GPPGWGLTVMPWVLVHLKPDM
MDQYYQLSKRYGPSVRVGPNTVITFIRKMSAVQSPCRRSMNYYAMRLNPGKDHLFSTRNEVAHNDLRKTMTAHYSGKENL
SLENDVDESILELCHLIDNKYSSTAGNIKPMHLARKISFMVLDIISKVAFDAKFYDLTDDRDNHGHIAEIENLLPSITWI
APVAGLVKFLTDIGLLQMAARFAGGRAGVEKKRFQPDGRPKDEMRSDMLGSFIRHGLSHERAKEEAILNLTAGSDTTAST
IRATMLNIMASPRLYRLLTAEIDDAVARGALPPEGKIVSANQAHELLPLLQATIKEGLRWYPAVAAELSKLTPPQGDTIC
GYYVPGGTKVGTSMKVLYRNEELYGPDAEAFRPERWLLSSESRSPGTLEPFWDTRTSAMTLNAKGCLAFPPRTCSTHEWF
FDIARQCSDDTYIHSSISTTDRPHTSNISGLPSSNPLKSVDSDFFFLFQKTWYLKPLRPRSPQPA*
>CYP571 # name changed to CYP535
no sequence
>CYP572A1 Magnaporthe grisea MG04345.4 poor match AACU01001098 cont2.822
MAVTSLSTLALFVPILVIGSLAWRIIHSLYFHPLSKFHGPWYAASFSIVH
ALASTLKVEHEWLLQLTKRYGASKPIRIAPNLLLFPQPSAVKEIYWDSKL
NTKGLFYGSGALGPPHLFTTLDGDQHKELRKAIGGPHYTIGTLKNHWEPR
FDDLILTALEKWTEKSERGETIQLCDKVAEFAADVMTMVSFSEPWGFVRN
DRDERELLKRWRDSLPYFGFVNRFRWFRDVVMKSSWGVYFLPSSSDNTGM
GFFMREADRQVTIREYRMKNQQYSQECPDFLQHCLEARIGTKPLSPVQKR
AHITLLFQAGADTTGTALGCTFRFLVTNPDVMSRCQAEIDAADQAGKLSS
PVVQYEETRTHLPLVVACIRESLRLHPPAPTLFPRIVPRAGGGGLGAKKT
SSSGGFKTIGDVVLPPGFEVTTHPYVVQRDPVLYAPDPEVFRPERWLEAS
PEKLSEMEAGQFTFGVGPRVCLGKDVAYMELYKLIPQVLRTFDMDLQRPG
QFVVAGGVAFNNDFAVKLRVRKSGETFMHD*
>CYP573A1 Magnaporthe grisea MG05215.4 poor match AACU01000797 cont2.962
MAILSPVGLVLIPLAYIVYKILQQIAKYRLNHPLNPFPGPWLASVTRLWI
TYHNVKADECQTFRELHRRHGPVVRITPTMLHVSDAVKLPEIYSRNADKS
QHYITGSFGTTESLFNMQDHKVHAHFRKIAASPYSFSNVKRMEPLLDSNI
DRWIHRLDEQFASTRQRFDFAPWAVYMAYDIISEVGFGQPFGFIEQGRDV
EGLIKGFHDGLVPFGIMARLWPFTNWVKTTFLGRYLVASPEQDSGIGTLM
RLRDRLITQRIADNEKSGGNSHARVDLLQTFLEARDDEGRPLDVAHVKAE
ILLVLLAGADTTGTTFQAIVMHVASRPDVYERMMAEVDAAAAAGKLSSPT
PRHEEVQAHCPYYVACVRETMRLNPAAPNIFPRLAPAGGIDLYGVRVPGG
TELTCNPWIVHRDPAVVGDDPDHFRPERWLEDGDRAKAMLRYSMSFGYGA
RECLGKHIAMELFKAPIRFFQTFKPDILDKTNPGRYVVKGGVSYFEDMWI
KIERRVRVE*
>CYP573A2 Fusarium graminearum FG03008.1
AACM01000145
FGcontig1.145_scaffold2, C-term revised
MALLSIVNVALLGVAYFVACAVWQVVKYRFLHPLAKFPGNFWGSVTRLWI
TYHNVEADECETFQELHKKHGPIIRITPTMLLVSDATELPKIYNRHANKS
KHYITGSFGKDESLFNMQDSVMHAKYRKVAAPLYSLTNIKKMEPLIDNNM
SAWMSRLQRDFAATNKPFDFAPFSVYLAYDVISEVGFGAPFGFVKEGKDV
EGLIQGFHDGLTPFGIMARLYPFTNWVKSTFLGKYMVASPEQDSGIGILM
RFRDRLIEQRFKDIENGSTGGRIDLLQTFIEARDEDDKPLDINYIKAEIL
LVLLAGADTTGTAFQAMMVHILTNPSVYKKLLAEIDEATAAGNLSEMPQY
DEVVEHLPYYIACVKEAMRLTPSAPNIFPRIVPQGGLEICGHFVPEGTEV
TCNPWLVHRDPNIYGDDAEIFKPERWLDADKAKIYNKYSMGFGYGPRVCL
GQDIARMELYKGPLLFLRSFNVEWVDETKRGKYVINGG
VSYFEDMNIKISRRDAAA* 123417
>CYP573A3 Aspergillus nidulans AN7773.1 57%
to 573A2 53 clan
MGLGELALSQLTLANVVLGGIAYIVLKFIYQIVYYRFFHPLSVFPGPFWG
SVTRLWIAWHNLKETELPTIYGLTKKYGPVVRVTPTLLLVSDPTKLPEIY
HRNADKTGHYITGSFGETESLFNMRSHKTHAAFRKHAAGPYSFSSVKRME
PLIDARIRDWSNKLNEKYVQTGEAFDFSWWAVYMAYDIISEVGFGAPFGF
VEKGEDVGGLIQGFHDGLPAFGLLARLHPFTSWMKTTFLKKYLVAKPEDD
SGIGVLMRFRDGLIEKRVQDLKSNKDIGRIDLLQTFLEARTEDGQPLTMD
YIKAEILLVLLAGADTTGTVFQAMIYYLLTNQSVYERMMDEVDTAIRKGL
ITDDVPQYIEIQEHLPFFVAIVRETLRMCPPAPNIFPRYVSEPGLDLYGK
VAPAGTEITGNPWIMHRDEAVFGKDAEEFNPDRWMDPERAKIMNKYLFTF
GYGARVCLGRDIAMMELFKGPLQFFRYYKPYPVQGKPEAKFVIKGGVGFW
RDMWVKIEKRPLVKPE*
>CYP573A4 Nectria haematococca
e_gw1.23.293.1
Necha1/scaffold_23:206165-207796
MAVLSFANLALLGVGYVVLSFAYQIIKYRFFHPLAKYPGNFWGSVTRLWITYHNVKADECATFQKLHQQH
(1)
GPVIRITPTMLLVSDATKLPQIYSRGASKSKHYITGSFGKEESLFNMQDATVHAKYRKIAASPYSFSNIK
RMEPLIDINIQAWMDKLQETFASTQKQFDFAPWAVYMAYDIISEVGFGAPFGFVEAGKDVEGLIKGFHDG
LTPFGIMARLYPFTNWVKGTFLGKYMVASPEQDSGIGTLMRFRDRLIQQRFKDIEDGTTSGRIDLLQT
(2)
FIDARDEKGEPLDINYIKAEILLVLLAGADTTGTAFQAMMVHILSNPCVYEKLLAELDEATRANKLSDMPQY
EEVLAHCPYYIACVKESMRLNPSAPNIFPRLAPKGGLELYGEFIPEGTELTCNPWLVHRDPNIYGEDAQV
FRPERWLDEEKAKIFNKYSMGFGYGARVCLGQDIARMELYKAPLQFFRTFKFELADTKKPGTYVVKGGVS
YFEDMYIKIQRREELGRTA*
>CYP573A5 revised Aspergillus oryzae RIB40
AP007157.1a genomic DNA, SC023
75% to 573A3, 60% to e_gw1.23.293.1
79% to CYP573A6 Aspergillus
fumigatus
complement(join(116142..116234,116333..117206,
117277..117401,117462..117649,117710..117944))
revised 3/17/2009
Supercontig 8: 116142-117944 (-) strand
MVLAGEDLVAMFTVTHVILALGAYVALRFAYQIVYYRFFHPLSVFPG
PFWGSVTRLWIAWHNLRETEVPTVYALTKKY (1)
GPVVRITPTLLLVSDPTKLPDIYHRNA ()
DKTGHYITGSFGETESLFNIRSHKTHAAFRKHIAGP (0)
YSFSNVTRMEPLVDARIDDWLNKLDETFASTGAKFDFAWWAV ()
YVAYDVISEIGFGAPFGFIEQGKDVGGLIQGFHDGLPAFGLLARLHPFTSWMKTTFMKKY
LVAKPEDNTGIGVLMRFRDRLIEQRLREIAEGKDVGRVDLLQTFIDARTEDGKPLDMDYL
KAEVLLVLLAGADTTGTVFQSLVNHLLVNQEVYERMMEEIDTASRKGLIPETIPQYDAIQ
EHLPYYVACVRETLRLNPPAPNIFPRYVSEPGIELFGKFAPAGTEVTGNPWIMHRDTALF
GEDAEEFRPERWLDPEKAKLYNKYIFTFGYGTRVCLGRDIAMEELFKGPLQ
(0)
FFRRYTPSIATDKPSARFEVKGGIGYWRDMWVSINRRPAVKPL*
>CYP573A5 Aspergillus flavus
99% to CYP573A5 Aspergillus oryzae, only 1 aa diff
AFL2G_03949
Note> end is n a sequence gap
MVLAGEDLVAMFTVTHVILALGAYVALRFAYQIVYYRFFHPLSVFPG
PFWGSVTRLWIAWHNLRETEVPTVYALTKKY (1)
GPVVRITPTLLLVSDPTKLPDIYHRNA ()
DKTGHYITGSFGETESLFNIRSHKTHAAFRKHIAGP (0)
YSFSNVTRMEPLVDARIDDWLNKLDETFASTGAKFDFAWWAV ()
YVAYDVISEIGFGAPFGFIEQGKDVGGLIQGFHDGLPAFGLLARLHPFTSWMKTTFMKKY
LVAKPEDNTGIGVLMRFRDRLIEQRLREIAEGKDVGRVDLLQTFIDARTEDGKPLDMDYL
KAEVLLVLLAGADTTGTVFQSLVNHLLVNQEVYERMMEEIDTASRKGLIPETIPQYDAIQ
EHLPYYVACVRETLRLNPPAPNIFPRFVSEP
>CYP573A6 Aspergillus fumigatus Af293
XP_748848.1
also EAL86810.1
68% to 573A3,
95% to CYP573A6 Neosartorya fischeri
AFL2G_03949
revised
3/12/2009
MGLREEILARLTLSHVVLGLVAYVLLKFVYQIVYYHFFHPLSVFPGPFWGGVTRLWIAWHNLRETELPTVYALTKKY
(1)
GPVVRITPTLLLVSDPTKLPDIYHRNADKTGHYITGSFGETESLFNMRSHKTHAAFRKHLAGP
(0)
YSFTNVKKMEPLVDIRIQHWIDKLNEKFAQTGEIFDFSWWAVYMAYDIISEIGFGAPFGFVEQGQDVGGLIQGFHDGLPAF
GLLARLHPFTSWMKTTFMKKYLVATPQDDSGIGVLMRFRDRLIDQRFRELETKKDIGRIDLLQTFIEART
EDGSPLDMEYLKAEVLLVLLAGADTTGTVFQALVHFLLTHRDAYRRLMEEIDAATAQGLISDPVPQYDEI
VEHLPYYVACVRETLRLNPPAPNIFPRYVSEPGMDLYGKFAPAGTEISGNPWIMQRDKKLYGEDAEEFKP
ERWLDAERAKRYNKYSFTFGYGARVCLGRDIAMMELYKGPLQ ()
FFRRYHVQTVTDKPKARFVIKGGVGFYRDVWVTIDRRLPQKA
>CYP573A6 Neosartorya fischeri
95% to CYP573A6 Aspergillus fumigatus =
ortholog
NFIA_027910
MGLGEEFLARITLTNVVLGLVAYVLLKFAYQIVYYHFFHPLSVFPGPFWGGVTRLWIAWHNLRETELPTVYALTKKY
GPVVRITPTLLLVSDPMKLPDIYHRNADKTGHYITGSFGETESLFNMRSHKTHAAFRKHLAGP
YSFTNVKRMEPLIDIRIQHW
IDKLNEKFAQTGEIFDFSWWAVYMAYDIISEIGFGAPFGFVEQGQDVGGLIQGFHDGLPAFGFLARLHPFTSWMKTTFMK
KYLVATPQDDSGIGVLMRFRDRLIDQRFRELEEKKDIGRIDLLQTFIEARTEDGSPLDIEYLKAEVLLVLLAGADTTGTV
FQALVHFLLTNPDAYRRMMEEIDAATAKGLISDPVPQYDEIVEHLPYYVACVRETLRLNPPAPNIFPRYVSEPGMDLYGK
FAPAGTEISGNPWIMQRDKKLYGEDAEEFKPERWLDAEKAKLYNKYSFTFGYGARVCLGRDIAMMELYKGPLQFFRRYNV
QTVNDKPKARFVIKGGVGFYRDVWLTIDRRLLEKA*
>CYP573A7 Aspergillus niger
fgenesh1_pg.C_scaffold_11000284|Aspni1
77% to CYP573A3
MSVGEDLLSKVTVTNVILGVVVYVVLQFVRQIVYYHFFHPLSKFPGPFWGGVTRLWIAWHNLRETELQTVYDLTKKYGPV
VRITPTLLLVSDPKKLPDIYHRNADKTGHYITGSFGETESLFNMRSHKTHAAFRKHIAGPYSFSSVKRMEPLLDAHIEHW
LQKIDERFASTGAGFDFSWWAVYMAYDIISEVGFGAPFGFVEQGQDVGGLVQGFHDGLPAFGLLARLHPFTSWMKTTFMK
KYLVATPQDDSGIGVLMRFRDRLIDQRLRDLEEKKDIGRIDLLQTFLEARTEEGKPLDMDYIRAEVLLVLLAGADTTGTV
FQALVHNLMTHTEVYERMMAEIDDAARKGLISPMAQYQEIVEHLPYYAACVRETLRMNPAAPNIFPRYVSEPGIDLYGQF
APAGTEISSNPWIVQRDEGVFGADANVFNPERWLDPERAKVMNKYMFTFGYGTRVCLGKDIAMMELFKGPLQLFRKFKLH
SIAGKPSAHFVIKGGVGFWRDMWVTVDKRGAVKAT*
>CYP573A8 Fusarium oxysporum
86% to CYP573A2 Fusarium graminearum
FOXG_12028
MAVLSFVNIALLGVGYIAFCALWQIVRYRFFHPLKKFPGNFWGTVTRLWITYHNVKADECATFQELHKKHGPVIRITPTM
LLVSDATQLPKIYNRHANKSKHYITGSFGKDESLFNMQDSVMHAKYRKIAAPLYSLTNIKKMEPLIDSNIENWMARLQRE
FASTNKPFDFAPWAVFMAYDIISEVGFGAPFGFVKEGKDVEGLIQGFHDGLTPFGIMARLHPFTNWVKSTFLGKYMVASP
EQDSGIGTLMRFRDRLIDQRFKDIENGATDGRVDLLQTFIEAKDEDGNPLDINYIKAEILLVLLAGADTTGTAFQAMMIH
ILTNPSVYKKLMAELDDATIAGKLSEMPQYDEVVEHCPYYIACVKESMRLNPSAPNIFPRIAPPGGLEICGQFVPEGTEV
TCNPWLVHRDPNIYGDDAEVFKPERWLDEDKAKVYNKYSMGFGYGARVCLGQDVARMELYKGPLQFLRSFKVDWVDEKNR
GTYVVKGGVSYFENMNITIQRREVVA*
>CYP573A8 Fusarium verticillioides
97% to CYP573A8 Fusarium oxysporum
FVEG_10612
MAVLSFVNVALLGAGYIAFCGLWQIIRYRFFHPLRKFPGNFWGSVTR
LWITYHNVKADECATFQELHKKHGPIIRITPTMLLVSDATQLPKIYNRHANKS
KHYITGSFGKDESLFNMQDSVMHAKYRKIAAPLYSLTNIKKMEPLIDS
NIENWMARLQREFASTNKPFDFAPWAVFMAYDIISEVGFGAPFGFVKEGKDV
EGLIQGFHDGLTPFGIMARLHPFTNWVKSTFLGKYMVASPEQDSGIG
LMRFRDRLIDQRFKDIENGATDGRVDLLQTFIEAKDEDGNPLDINYIKAEIL
LVLLAGADTTGTAFQAMMIHILTNPSVYKKLMTELDDATLAGQLSEMPQ
YDEVVENCPYYIACVKESMRLNPSAPNIFPRIAPPGGLEICGQFVPGGTEV
TCNPWLVHRDPNIYGDDAEIFKPERWLDEDKAKVYNKYSMGFGYGARVCLG
QDVARMELYKGPLQFLRSFKVEWVDEKNRGTYVVKGGVSYFENMNITIQRREVVA*
>CYP573A9 Aspergillus clavatus
76% to CYP573A3
ACLA_008360
MGLGESFLSQVTVTNVTLGLVAYVVLKFVYQIVYYRFFHPLSVFPGPFWGSVTRLWIAWHNLRETELPTVYALTKQYGPV
VRITPTLLLVSDPTKLPEIYHRNADKTGHYITGTFGETESLFNMRSHKTHAVFRKHVAGPYSFSNVRKMEPLIDVRIQDW
INKLEDKFAQTGKGFDFAWWAVYMAYDIISEIGFGAPFGFVEQAKDVGGLIRGFHDGLPAFGFLARLHPFTSWVKTTFLK
KYLVATPQDDSGIGILMRFRDRLIDQRFRELEANKDIGRIDLLQTFIEARTEDGSPLEIEYLKAEVLLVLLAGADTTGTV
FQALIHFLLTHPAAYRRMMKEIDSVSAQGLLSDPVPQYDEITAYLPYYVACVRETLRLNPPAPNIFPRYVSEPGLDLYGR
FAPAGTEVSGNPWIMQRNPAMYGEDAEEFRPERWLDADKAKVYNKYLFTFGYGARMCLGREIAMMELYKGPLQFFRRFNI
TPMIDKPAARFVIKGVLGSTGICG*
>CYP573A10 Aspergillus terreus
78% to CYP573A5
ATEG_01019.1
MGVVEEGLLSKLTVTNAVLALVAYVGLKFLYQIVYYRFFYPLSVFPGPFWGSVTRLWIAWHNMNETELPTVYELTKKY
(1)
GPVVRITPTLLLVSDPKKLPEIYHRNADKTGHYITGSFGETESLFNMRSHKTHASFRKHIAGPYSFSNVR
KMEPLIDARIGDWLAKLEEKFVSSGEEFDFAWWAVYMAYDVISEVGFGAPFGFIEQGKDVGGLIQGFHDGLPAFGLLARL
HPFTSWIKTTFLKKYLVAKPEDDSGIGVLMRFRDRLIDQRLRDMEKSGGDIGRIDLLQTFLDARTEDGKPLDMEYIKAEV
LLVLLAGADTTGTVFQALMYNLFVNSEIYERMMEEIDNAVRKGLISEDMPQYDEILEHLPYFVACVRETLRLNPPAPNIF
PRYVSEPGMDLYGRFAPAGTEISGNPWIMQRDRGLFGEDAEEFKPERWLDPEQAKLFNKYLFTFGYGARVCLGRDVAMME
LFKGPLQFFRHFKPTVVPGKPPARFVIKGGVGFWRDLWVTIEKRPQVTRE*
>CYP573B1 Mgf Mycosphaerella graminicola
42% to CYP573A7 A. niger, 43% TO
573A2
MTARPATVRNVMSSLSTRDLAYGALFSLTWVVVVHVIWRIVHYRYYHPLRHYPGPWLASVTRMWLAWHHFWGTELHAQWALIKKHGPVIRITPTMLLVADSKEMPIIFHRRDTKSRFYLQGYVGKSNSILLREPGAHAAHRRLIGAPYALANIQRTEPLLDKHILHWISTIDARYAALGKPVDFSHWSHFLAYDTITDLGFRNPLGFVKAGSDVGNLIGGFRIGMLMFGVAGRLYPFTEKLLNSWFKKWLVVRTEQQLGFAVVMEKAGAILAERRDRIKRGLKAEKGEGSYDLLQAFMDARTPDGDHLADDTIVSEIFVVLGAGSDAFGSASTAFMASILSRPTIFRRLMDELEDAIADGKLSYPVPSYAEVSQHLPYYAACIKETLRLDPSGATLLPREVCPGDPELILNGHVVPIGTEVAMNPWIAHRDVNLYGPDAEEYNPDRWLSDPARTKIYEKYNLAWGYGARLCLGKPFAMMELYKGPLSLLLNFDVTIAEIGPNTPAPHSEMYATVKVWGDVWLQLQRSDRWSSWSSLGKSHIPGEIEDRSGQDGETEVR
>CYP574A1 Magnaporthe grisea MG05854.4 poor match AACU01000833 cont2.1101
MIHSTVHLGTYCLAAAAFGLASHWTYWVHGHRVRHATWTFLFHLAALFIL
GWKLTSVQGNLLSGLGATAAIFLSYLGTLFTSIVVYRVFFHRLAHFPGPF
FAKVTKLYGLYAARNSQVNDHHTSLMRQYGDFVRIAPNELMVMAPEALSK
VQGMTSKCSKKNTGIFDILHSKGDRMIVALLEKDEHIARRKIWNQALDTK
LLPQYEPKVRKEVMLWLDTLSKIQGPIDITHYMMLLSFDLTGAVGYSADY
QTIKTGKENRTLHLLEASFKPFGKLGFLAWPVQIALELGLAKEQKEFEKL
AVKTVDERVADDSEEKVDILKYFLQDFRTKQTSFRSMNSIYTESQAILIG
ATDSTSGTMAWILCYLIKHPSVAATLLQELEPVFGKTTPGEFSDADLRGL
PFLQAVIDETLRLQPPAGNGSARMTPPEGIEIAGTHIPGQVSVWVPVRAQ
QRDERFFAQPDDFIPERWTTRPELVLDRRVYAPFNTGRWSCVGKQLSFMI
MRMVIAHTLWHYEPSFAPGEDGNDIGLKRQDLIIAKPGKLELRFTPRKPR
I*
>CYP575A1 Magnaporthe grisea MG10343.4 poor match AACU01001708 cont2.1991
MNFSLNSLSHAQVLGLGVALCLLGYIVTTELRYRHLWGYPGPILARYTNA
YRAYLAWRYANRPGGISYHEYLHNKYGTTVRMGPNIVYTDDPDAIPLVLG
FKDRLMKTDHVNALQVPGQPANIGGIRDEKEHNRSRSAIEVVYSLSSLKG
YEPLVDETIVELTRVFEDKARAGEVVNISEWCHYYAYDAITNVTYGEPTG
FIRNGRDMFDLISSQLKHIAYVRMATQWPFMDYVLRTNPIALALNKQKAS
RAGTFFQYSADRVNAEMAKEKRSAVAQKTMLHHLIDARDKHPDVLDDQRV
QMFCTVNLLAGTLSPSFAVDFIMRWLAQNPEKQERVYREVKQHSTTYPVP
LDDTFKMPYLQGLVREGYRLSYASDIGMERVAGPKGIPLRDGRMLPPGYG
IGLSHPAIQKDAAVFGDQPEVCRPDRWMQGPDESLADYKARKGYMDRTDL
TFSKGSRNCIGKGYTQMEVAKVVASVAARFQLHLAGEAHIRDLLRIRNRL
SVILKGTD*
>CYP576A1 Magnaporthe grisea MG09057.4 69% to CYP576A2 AACU02000558
MAVFSVVLGVAAMLATMILIQVRGILKAYRSPLSRIPGPWYAPLTTMHLR
WGFSTGEIWKLVERSHKAYGPIVRLGPRQVWVADKDALKEILVKVDLPKV
AMYSEISRDKHSPGLFGEIRYEPHKRLKRFLSPAFTVAYIDNLEKYFQKT
MRELLNKYESQMNADPGAVSFNGIEVDLMDDLHNVALDIMGECSFGKGFG
QTNPKTSVVEEGVDEKVWKSIPRSIFDGLSKRYQMVYVKKFLRMFGLDVN
FDWPAEMIT (0)
QQQTSRRDLLQHLIEEGKKPDSGTAMNTRDIVDQMAEILLAGSETTSGTIACLFL
ELARNADVRAKLLASLPARGAGDEVVASKAIRSDAGQYWYLEACIKENLR
LHPIASEMGRRTGKDWVTIMGYDLPPHTVVSASYRDLHRNEKYWPEPLRF
WPERWLPEGQRDGAPAADMNAYYPFSAGKHSCIGINFAWAEMRMVAANIF
SRFDIEEVPGQVIDFRQYITMQFHTGNWRVVLRPRSRPAPPASSKSDDKN
QGEKQETLIEA*
>CYP576A2 Phaeosphaeria nodorum SN15
AAGI01000365.1 cont1.365, whole genome shotgun sequence
69% to 576A1
43011
MYIFIIYILFVAIAASQVFKRIKAFRSPLREVPGPWYAPLTTLHLQYLFSTGNIWK 42844
42843
YVEKGHKCYGPIMRVGPRQVWISDKDAMKQILVKQDLPKVAMYAEISRDRASPGLFGEI (2) 42667
42610
RHEPHRRLKRFLSPAFTVAYVDNLEVHFQKIVRDLLNKYQSKVVSSAASERGFETDFM 42437
42436
EDLHNVALDI (2) 42407
42357
MGECSFGKGFGQTNPESKGEDGVDERIWKSIPRSIFDGLSKRYQ (0) 42226
42155
TVYIKKLIRFFVMDIKFDWPAEMIA (0)
41990
TSGTERQDLLQHLLEQGKRPDTGVTMNTRDITDQMAEILLAGSETTSGTLACLFLEL 41826
41825
ARNPVVYNKLLESLPSASLADDIVSSKTVRTESQYEYLEACIKENLRLHPIASEMGRRT 41649
41648
GTEWVNLMGYDLPPHTVVSASYRALHLNEEYWPQAQRFWPERFLAKDKRGDAPAAD (2)
MDAYYPFSGGKHSCIGIN (2)
FAWSEMRIVA 41289
41288
ASILSRFRLFEVSNQEVDFRQYITMQFATGEWKVILEPRQVEMS* 41154
>CYP576A3 Aspergillus terreus NIH2624
AAJN01000022.1 cont1.22, whole genome shotgun sequence
AC boundary before RHDPH (intron 1)
60% to 576A2, 59% to 576A1
ATEG_00955.1
65914
MGRLVEQGIVHPYYSFILLIIFLLCVSYIIGVVKAIVSPLSRIPGPWYAPLTTLHLNYAFATGKIWKIVEKG
HQEYGSIMRLGPRQVWVSDMEAMRTILITADLPKVTMYAEISRDRSSPGLFGEI (2) 65537
65481
RHDPHKRLKRFLSPAFTVSYVDKLEPLFTECLKDLIVKYSDAFSSRRFETFTQPA
TMDLMDDLHSLALDI (2) 65272
65224
MGECSFGRGFGYTNPQKETTFGIDEKIWSGIPSAIFKGMAQRYQ (0) 65093
65040
MVYFKRLLRKIGVDIKFDWPDSMIA (0)
64960
64856
KNLGPDLLQHLIDEGEKPDSGMKMVPRDVIDQMSEVLLAGSETTSGTIGCFFLEVLRNPQVKARL 64677
64676
LEALPVLLPNDSIITSKAVRTDSQYEYLEACIKETLRLHPIASEMGRRTLNQSIELIGFS 64497
64496
IPPHTFVCASYRDLHRNPAYWPDPLRFWPERWLQNRPPDVP 64374
LTAYYPFSAGKHSCIGKN (2) 64250
64153
FAWAEIRMVTANLLSRFEFIEVPAQDIDYRQYITMQFANGSWKA FLKPRYESRAEFFTI* 63974
>CYP576A4 Aspergillus niger
e_gw1.20.142.1|Aspni1
68% to CYP576A3
METISERLPVYFHWAPLFILALLFFNYIIGVTKAIKSPLSRIPGPWYAPLTTLHLNYAFAKGTIWKAVERSHAKYGPIFR
LGPRQVWISDKEAIKAILMTVDLPKVTMYAEISRDRSSPGLFGEIRPDPHKRLKKFLSPAFTIAYVDGLEFLFSECVGDL
INRYVDLLSSPTSRGQKELVVTDLMQDLHSLALDIMGECSFGNGFGQTNKNKKLELELDEGIWRSIPTAIFKGMTRRYQF
VYIKRLLRRLGLNIEFDWPREMIAAISAVAGHRKAKPKSVRPDLLQHLLENGERPDSGVKMGTREVVDQMAEILLAGSET
TSGTIACFFLEILRNPEIKEKLLKSLPVLRPSDPIISSKTVRTSPEYEYLEACIKEVLRLHPIASEMGRRTGNTPVKLMG
YYLPAHTIVSASYRQLHRDPKYWVDPLRFWPERWLDPRPSDVPAPDMHAYYPFSAGKHSCIGKNFAMAEIRMLTANILSR
FDLDEVPGQNIDYRQYITMQFEHGSWKAFLTPRYEQSTPVS
>CYP576B1 Mgr021 Mycosphaerella graminicola
52% to 576A1
MGIISILLPSLAAFLLFQWAISAWRAYNSPLSALPGPWYAPFTNIHLQIGFARGTVWRQVEAAHAKYGGMMRLGPRQIWV
SDKVALKQIISQIDLNKVMMYAEMSRDKNSAGLFGEVHKRLRKLMTPAFTVGYLDQMDHLFQKPVEDMMNLYKSNLKPKS
AVDGMKVNLMTDLHKIALEVIGECAFGRGFGSVAPDTEPEPGFSKEQWQKIPDNIAKGLSMRYAIVFLKRSLRKLGIHME
FDWPAEMVAAIESVITRRRAGHEAGRQDLVQHLIDNGVRPDNGQKMSARDILDQLSELMLAGAETTSATMCYFMMELARN
PDVRKKLFKDLPALGLDDPLITGVEVRQDPRFAYLTACMQENLRMHPIASEFGRRTTDKPVVLNGFEVPPYTVVSASYRA
LHYNEEYWPQPHRFWPERFLPIDHPLKGDAPNADTSAYYPFSSGKHSCVGMNFAWHEMRVVLANYCARFDITEEPGQKED
IRQYITMQFHDGNWNARLYPRL
>CYP577A1 Magnaporthe grisea revise and shorten at
C-term
MNQGNLIYTATQYCAPHLAGIATTLAIAYVLYALIVLPLAASPLRAIPGP
KAYAATRWRLAWDDYRGARTRVIHSLHKQHGSAVRIGPGEVSFSSLSALR
TIYGAGSGFERTNFYRMFDVYGRQNLFTFAGAKKHGERKKVLAHAYAKSV
VLADGSVAKPLIENNVRRFLELIEREKEATSKIFDSLHWFSLDSITGFLY
GDQHGGTRALRGDRADRAMLDDIRDPARRKLTWFAFHLKLYTKWLYSQTG
LLEKTINVLGLLPMSKPTTYTAIRAHALKSCVASEAETNETNVTVDKASF
IMSKLWAYSKSEKEPRMDRLDIASEAADHFLAGIDTTSDTLMFAIWALSL
PENRRCQERLIAEIDSMSPELFNQGTKALGSAVAAAEVADRLPYLNAVIK
ETLRLFAPIPGSEPRSMPVDTTIDGYRIPAGTVVSMSPYTLHRNEDVFPQ
TLEFRPERWLGELGDLVEMKKYFWAFSSGGRMCIGVH (2) 7915
7820
FAMAEMTTLLASLYKHYSTCEQERQKGSSPAISSRFELFYDERFTQIS (0)7674
EHACYIDFKRRTH*
>CYP577A2 Fusarium graminearum AACM01000316.1
Gibberella zeae PH-1 revised (formerly 577B1)
MAILPLAAAVVAVALLVKYLLDPFLSPLRQVPGPKLFAATRWRLAYEDWK
GTRTRTINALHKKYGPVVRIGPNEISFNSLSALRTIYGPGSRFGRTSFYR
MFDVYGEQNLFTFHSPKDHGDRKKLLSHAYSKTAVLKPATARMIERQAWR
YLNLIDSEPEGVSEIFSTLHYYSLDNITAFVYGKYGATAAVRGSKIHRDL
ISDILHPSRRRLSWCIVHVKGFTQWLYRQSSFMGALVKPILPMQQPTTYT
GIRAYALSAFKQFRAEADSQEVKFTEDEHVSILERLWQYHETQRPDGMRD
LQMASECADHFLAGIDTTSDTLMFLVWSLSLPGNEKFQEKLREEVQAISD
DSLNKQGIPKAEVADRCVYLQAVIKETLRLYAPLPSTEPRSTGDDVTIDG
YVIPKNTVVGMSPWIMHRNEEVFENPLVFNPERWLGEKASELNRWFWGFS
SGGRMCIGMHLAMAEMTVLGAALYREYRTTIAPGFEDTSPAITARVETFY
DERFPKVK (0)
ESTCLVKFDKLKK*
>CYP577A3 Nectria haematococca
estExt_Genewise1.C_270019
Necha1/scaffold_27:156564-158470
64% to 577A2, 55% to AP007157.1g orth Aspergillus oryzae
last exon seems unneeded, continue exon 3 to
stop codon eliminate exon 4
MASFSITIALSVLFLLLIKYYVLDPLVFTPLSRVPGPTAFALSKWRLGYEDWKGTRTPTIQHLHSKYGPA
VRIGPNEVSFNSLTALKTIYGPGSRYGRTAFYRMFDVYGEQNLFSFHSVEEHGSRKKLLSHAYAKSTVLK
APTTQLFEEKTRQYMELISGEPNHISDVFHTLHYYSLDNITSFIYGKHGSTSALQGSEADRALISDIMHP
SRRMLSWCLVHMPSITKWMYARTGFMRQLMKPLLPMQLPTTYTGIRKFALQAFENFQSDSEKTN
(1)
GNERSILAHLWQHHQTQKTNGLNDMQTASECADHFLAGIDTTSDTLMFLLWSLSLPENQRFQDKLRDELLGLPAEA
LNQHGYPKAEESDRCTYLHAIIKETLRLYAPLPSSEPRSVNAASVVDGYHIPADTVVSISPWILHRNPKV
FKDPLEFNPERWLGPDATELNRWFWAFSSGGRMCIGMH (2)
LAMAEMTTLIATLYREYQTSIAPGFENTTPGITARVEVFYDERFPKLQ (0)
ENTCLIKFDRLRK*
>CYP577A4 Aspergillus oryzae RIB40
AP007157.1g orth genomic DNA, SC023
53% to 577A2 probable ortholog
join(1148972..1150341,1150393..1150552)
1148972
MTITLVAIATGIVAFILYYICWSLFSSPLARIPGPKSFALTKWRLAYEDYKGTRTRKIHALHERY 1149166
1149167
GPVVRIGPNEVAFNSLSALRAIYGAGSGFERTNFYSMFAIYGRKNMFSFNTVKQHAERKK 1149346
1149347
LFAHAYAKSAMLKGINASMIETKVRKYMEFLEREGRSQDIFTTLHYFSLDNITEFLYGD 1149523
1149524
FGKTACLDGIEEDRALLHDILATGSRTLSWLTVHHPKLTAWLYSRTGFLGCVARQFYPMQ 1149703
1149704
RPTPYTSIKLHATKAFQGFADASVAEKAKQSSLISKLWKHHRSMKDGGLDNLDIASECAD 1149883
1149884
QLDGGIDTTSDTLMFTIWSLSRPEHWGFQQKLIDEVRSISEHDLNPEGIPRVEAADKLPY 1150063
1150064
VEAVIKETLRLFAPLPASEPRSSPEATTIDGYLIPARTVVSISPYTLHRNAEVFKNPLEF 1150243
1150244
NPDRWLDPSQDLTEMNRFFWAFSSGGRMCIGMH (2)
1150394
LAMAEMTTFVAALYRKYTTEPRGGFGTISPGITSRFEVFYDEGCSDMR (0) 1150537
EHQCQIEFKLQ*
>CYP577A4 Aspergillus flavus
99% to CYP577A4 Aspergillus oryzae
AFL2G_04292
MTITLVAIATGIVAFILYYICWSLFSSPLARIPGPKSFALTKWRLAYEDYKGTRTRKIHALHERYGPVVRIGPNEVAFNS
LPALRAIYGAGSGFERTNFYSMFAIYGRKNMFSFNTVKQHAERKKLFAHAYAKSAMLKGINASMIETKVRKYMELLEREG
RSQDIFTTLHYFSLDNITEFLYGDFGKTACLDGIEEDRALLHDILATGSRTLSWFTVHHPKLTAWLYSRTGFLGCVARQF
YPMQRPTPYTSIKLHATKAFQGFADASVAEKAKQSSLISKLWKHHRSMKDGGLDDLDIASECADQLDGGIDTTSDTLMFT
IWSLSRPEHWGFQQKLIDEVRSISEHDLNPEGIPRVEAADKLPYVEAVIKETLRLFAPLPASEPRSSPEATTIDGYLIPA
RTVVSISPYTLHRNAEVFKNPLEFNPDRWLDPSQDLTEMNRFFWAFSSGGRMCIGMHLAMAEMTTFVAALYRKYTTEPRG
GFGMISPGITSRFEVFYDEGCSDMRERLQG*
>CYP577A5 Gibberella moniliformis
AAIM01003330 GC boundary at CVGM
2400
MAILPIAAAVLAVVLFIKHIFLDPLILSPLRHVPGPKSFAATKWRLAYEDWKGTRTRTIF 2579
2580
KLHQLYGPVVRIGPHEVSFNSLSALRTIYGPGSRYGRTTFYRMFDVYGEQNLFTFHSPKE 2759
2760
HGDRKKLLSHAYSKSVVLKPPTAKMVERRVRQYLDLIEAEPENISEIFSTLHYYSLDNIT 2939
2940
AFVYGKYGQTAAIRGSKIHRELIADILHPSRRKLSWSIVHLKTLTQWLYRQSGLMGQLVK 3119
3120 PVLPMQQPTTYTGIRGYALRAFEAFRADVEKITHSE (1)
DEHVS 3293
3294
IVENLWQHHESQKPGGLRDLQMASECADHFLAGIDTTSDTLMFLVWALSLPGNEKYQEKL 3473
3474 REEVMAISGDGLNQWGNPRAEASDRCTYINAVIKETLRLYAPLPSTEPRSIDIDSVIDGY
3653
3654
SIPGNTVVGMSPWIMHRNEKVFKDPLVFNPDRWLGPDAAELNRWFWGFSSGGRMCVGM (2)3827
LAMAEMTTLTATMYRQFRTTIAPGFEDTTPAITARVETFYDDRFPK (0)
ESKCLIKFTKLKE*
>CYP577A6 Mgr082 Mycosphaerella graminicola
55% to CYP577A3 Nectria haematococca
MLTLIIFAASLAAAFYQFIVQPLYLDRLSKIPGPKLYALTKWRLALEEWRGARTRTIDALHNQYGPVIRIGPNEIHCNSLAALRTIYGAGSGYGRTSFYRMFDAYGKQNLFTFYSNKAHGDRKKLVANAYSKSVILKGPTASLVREKVSQYMSLIEEGGTKPHEIFSSLHYYSIDSITHFLYGSKFGGTSALTGSTADRKLLQDILDPTRRRLSWFAVHLPALTKWLYTRTGSMERLVKPLLPMQKPATYSGIRKHALDAYWGFEKAATAEPSATLADPTIITQLWKSHERVKASGAGALDSLDIASECADHLLAGIDTTADSLMFLVWAVSRPQHEALQRRLIDELRSLPEDELEDGVPKLETLDTLPVLNAVIKETLRLYSPLPASEPRSLGVDRTVDGYDIPAGTTISMSPYSLHRNEEVFKDPLTFNPDRWLNSSLEEVAEMNRWFWAFSSGGRMCIGLHLAMAEMTALVAAVYREYTTSIAPGFENKTPAITSRFEMFYDVTVPEIAEHECMITFERH
>CYP577A7 Fusarium oxysporum
97% to CYP577A5 Gibberella moniliformis
FOXG_13528
MAILPIAAAVVAVVLFIKHIFLDPLILSPLRHVPGPKSFAATKWRLAYEDWKGTRTRTIFKLHQQYGPVVRIGPHEVSFN
SLSALRTIYGPGSRYGRTTFYRMFDVYGEQNLFTFHSPKEHGDRKKLLSHAYSKSVVLKPPTAKMVERRVRQYLDLIEAE
PENVSEIFSTLHYYSLDNITAFVYGKYGQTAAIRGSKIHRELIADILHPSRRKLSWSIVHLKALTQWLYRQSGLMGKLVK
PVLPMQQPTTYTGIRGYALRAFEAFRADVEKITHSEDEHVSIVENLWQHHESQKPGGLRDLQMASECADHFLAGIDTTSD
TLMFLVWALSLPGNEKYQEKLREEVMAISGDGLNQWGNPRAEASDRCTYINAVIKETLRLYAPLPSTEPRSIDIDSVIDG
YTIPGNTVVGMSPWIMHRNESVFKDPLVFNPDRWLGPDAAELNRWFWGFSSGGRMCIGMHLAMAEMTTLTATMYRQFRTT
IAPGFEDTTPAITARVETFYDDRFPNVQESKCLIKFTKLKD*
>CYP577A7 Fusarium verticillioides
98% to CYP577A7 Fusarium oxysporum
FVEG_13880
MAILPIAAAVLAVVLFIKHIFLDPLILSPLRHVPGPKSFAATKWRLAYEDW
KGTRTRTIFKLHQLYGPVVRIGPHEVSFNSLSALRTIYGPGSRYGRTTF
YRMFDVYGEQNLFTFHSPKEHGDRKKLLSHAYSKSVVLKPPTAKMVERR
VRQYLDLIEAEPENISEIFSTLHYYSLDNITAFVYGKYGQTAAIRGSKIHR
ELIADILHPSRRKLSWSIVHLKTLTQWLYRQSGLMGQLVKPVLPMQQPTTY
TGIRGYALRAFEAFRADVEKITHSEDEHVSIVENLWQHHESQKPGGLRD
LQMASECADHFLAGIDTTSDTLMFLVWALSLPGNEKYQEKLREEVMAISG
DGLNQWGNPRAEASDRCTYINAVIKETLRLYAPLPSTEPRSIDIDSVIDG
YSIPGNTVVGMSPWIMHRNEKVFKDPLVFNPDRWLGPDAAELNRWFWGFS
SGGRMCVGMHLAMAEMTTLTATMYRQFRTTIAPGFEDTTPAITARVETFY
DDRFPKVQESKCLIKFTKLKE*
>CYP577A8 Mycosphaerella fijiensis
59% to CYP577A6 Mgr082 Mycosphaerella graminicola
e_gw1.6.418.1
MLEILVAATALLIAAYSIILEPLSLNPLSKIPGPKLYAITKWRLAWEDWQARRTRTIHALHQKHGPVVRTGPNEVHFNSL
TALRTIYGPGSGFGRASFYRMFDVYGKQNLFSFHSAKDHGERKKLLANAYSKSSVIRGHVAEMVSEKIQDYIHLLETQEN
IFTSLHYYSLDSITHFLYGTHGATQALKGDPASRSLMTDILDGPGRMRLTWFAVHLPAFTKWLYSRVGAVERLVRLFLPM
QKPLTYTGIRAHALKAMHMYTAAAAADKIDDTAKNTIIGRLYQSNAKLSDLEIASECADHFLAGIDTTSDTLMFLIWALS
RPGNEGIQQKIIDEAR SVPESDLDQYGAPTVEAADKLRYLDAVIKETLRLYAPLPASEPRCADIEMIIDGYTIPAWTTVC
MSPYSLHRNEEVFPEPLKWSPDRWHGDTEHVSMMKKWWWAFSSGGRICIGSNLALAEMALVPAIYRRYRTKIKSGEEKAS
PGITSRVEVLWDETFAEMKVSILFRGCV*
>CYP577A8 Aspergillus clavatus
56% TO CYP577A2 Fusarium graminearum
ACLA_067130
MESYMVKSFLLGVSLSLLYLIGKVFINLFQSPLRSIPGPKLFAITKWRLAYEDYRGTRTRYMKTLHDRYGDAVRIGPNEV
SFNSLSALRTIYGAGTVFQRDTFYRMFDAYGKQVMFSFASSKDHRARKKLLNHAYSKTSVLSPNNASMIEEKARQFMDLI
EKEAKDGSLEIFAALHYFSIDAITKFLYGKSAGATTALTASQDRSLLDDILDPDRRKLSWFTIHFPTLTNWLYSRTGLLE
SLLTDLGLLPMRKPSTYTGIRAHALAAAEHLSQSTTESLDVNASIAERLLVAGRTADPKGVPMDHLDVASECADHLLAGI
DTTSDTSMWAMFALSQPENQIFQDKLRAEVRSLGEEVTTDRVVSAIAADKQPYLDAVIKETLRLFAPLPGTEPRFADTDQ
IIDGYSIPKGTVVSMSPYTLHRNARVFQDPTRFNPDRWLGDAEAVAEMKRWFWAFSSGGRMCIGMHLAMAEMTTLLASVY
RTYKTEITPGFEGVSPGVTARYEVFSDEQFPRMEEHVCWVKFVKE*
>CYP577A9 Aspergillus terreus
54% to CYP577A8
ATEG_04675.1
MIPILCLGALLFGLVLFHVHKNLISSPLRHLPGPKSFAFTKWRLGYEEYRGMRTQCVNNLHKKYGEVVRVSPYEVSFSSL
SALRKIYGSG SRFERDDFYQMFDAYDRKVLFSYSSGIDH RERKKILNSAYTKTAIMSPSNVDMIEEKVKDFLALVQRDSS
ATGAVEIFSALHYFAMDSVSHFVYGATSPGRTTAMKGTRQHRGIIDDMLDPARRKLFWYAVFWPRLTEMLYAQGAIVQKS
LASFGLLPMKTPTYTGLRKHNFPVIQHLETQQLLGSDDSLASRLLAGTIPSAKASAPMDTLDVAAECSDHFLAGIDTTSN
TLMWVIYQLSRPENEGFQSKLRAEIQALDGPAGSGTFIYPEKAGTLPYLDAVIRETLRLHAPSPGSEPRWSTNDEVIDGY
TIPRGTVVSISPYTLHRQPQVFANPLRFDPERWLGPEDQVAERKRWFWAFSSGARMCIGVHLAMAEMTTLLANIYQNYWT
HIPSEYLQVSPGMSARGDLFYDEHLSQVEEHKCWIQFVPIRALSTCLQGCV*
>CYP577A10 Aspergillus terreus
70% to CYP577A8, 56% to CYP577A9
ATEG_07313.1 this model is a fusion of two
genes
MATFSLLTQYIWKWMQKSLFL SIFVAAIALVVLYGLAKVHRNLIVSPLRPVPGPKFFALTRWRLAYEDYRGTRTRCINNLHKQYGDVVRVGP
NELSFNSLSALKSIYGAGSGFQRDKFYRMFDAYGRQVMFSFAFSVDHR (1)
ERKKLLNHAYSKTAVLSSRNAAMVEEKTRQFLSLLDREAKSGIMEIFNALHYFSMDSITQFL
YGESQGATTALTASANRSLLDDIIDPARRKLSWFAVHFPHLTHWLYSRTGAMEWLLTTFGLLPMSKPSTYTGIRRHALVA
AEHIRDQTIEDPTESIAARLFHAMRTREKGPAMDYLDVASECADHFLAGIDTTSDTLMFAIFALSQPANLSFQEKLHQEI
QSLPDEVVVDDVVNALAADKLPYLDAVIKETLRLYAPLPGSEPRWSEKDEVIDGYRVPARTIVSMSPYCLHRNEHVYKEP
LEFNPDRWLGPSEQVAEMKKWFWAFSSGGRMCIGMQ (2)
LAMAEMTTLLASVYRKCRTEIAPGFERVSPGVTARYEVFYDEKFPRMEEHICWIRFRSR*
>CYP578A1 Magnaporthe grisea MG04605.4 poor match AACU01001135 cont2.866
MPFPVASSLLLSLVSIPVLVLTYHVIIYPAFISPLRKIPPAHWTVPFSPL
WILIVRLQGRENRVLHLAHQKLGRFVRVGPNELSVNDAGAVRTIYQGGFE
KTAWYSIFDNYGVPCMFSTVPAKEHSLRKRMISNVYSKSYIQSSQAAKAQ
AAAILHARLLPILEESAAKGREPHGIDIHSLFLAAAMDLITAYIFGLRHS
TDFLRNRGYREHWLQLYKARANYPFWRQELPRFTEVMSRLGLNLYPSWVD
ECNRELGEWNKKLCITVLASGVIGEETKPVDEPVVTKAMLAGLDKEAQAN
GDKSILYSTALQHHDLSVASELFDHILAGQETTGITLTYLVWELSRDQAL
QRKLQSELQTLDPGLKKQRDETGQWTATDAGSIPDLKALDSLELLHAVLM
ETLRLHAAIPGPQPRQAPHPSCRIGPYDVPGGTRVSALAHTLHREEAAFH
EPEKWDHERWLGGDEEARKLMNRHFWAFGSGGRMCIGSNFAMNEMKLIIA
AIYSNYTTHIVDDAGIEQDDGYTAGPKSGRLWVRLEPLV*
>CYP578A2 Nectria haematococca
e_gw1.24.56.1
Necha1/scaffold_24:249201-250960
53% to 578A1 in a P450 gene cluster
MGLVIPTAIGALALLLLYHHVLHPAFISPLRKLPAAHWTCHFSSIWILAARLYRRENRSLHEAHITLGPV
VRIGPAEVSVDGVEGMRVIYQGGFEKGFWYSVFSNYG (2)
VPNMFSTGSSKHHSARKRMVANVYSKSYLQSSQ
ASKAQMSHIVFQRLLPALSEHSSKDKLVS (1)
IFGLFLALAMDVITAYLFGLSNGTDFIQDEQYRQSWQEMYL
ARANYPFWTQEVPNLTAACV RWLPWLRLYPKWVDESNAKLCQWNLNLCQG (0)
QGKASAEPCEEAVVFNALQYGIDRELRTNGEKSILYRTSICERELA
VASELMDHSLAGHETTGMVLTYATWHLSKSPDLQEQLRSEIISIGSSLKLGRPSTVEAHEFEDTKSGPSL
PDLKALDALPLLNAIVMETLRLHAPIPGPQPRDTPKEGCNIAGYHIPGGVRIASMAYSLHRDPKVFPQPE
SWKPERWLPQDGTDMETSHREMHRQFWAFGSGGRMCVGSNFALNEMKVILAAIYANFRTTIVNDDGIEQE
DAYTARPVGEQLVLRFYTLDA*
>CYP578A3 Fusarium oxysporum
64% to CYP578A1
FOXG_06037
MGLILVTALGLLPVLLIYRYIIYPVFFSALSRIPAPHWTCHISPLWILAARKWRRENTSLYRAHQRLGPVIRIGPNEVSV
DGLEGMRTIYQGGFEKGHWYSVFDNYGVPNMFATGNSKHHSLRKRMISNVYSKSYIQSSQVSKLQMAEILVNRLLPALDG
SLEYSRKSISTDYNDVEVFGLYLATAMDLITAYIFGLSNATNFIADEPYRRDWQDMYLARANYPFWTQEVPKLTNFCKRW
IPWLKLYPQWVDQSNKKLSDWNWELCENVRKTSKVKRSPGNSQDIKFSDEPVVYNSLLAGIDREFKTNGEKSILYSTSIL
QRDRAIASEVMDHSLAGQETAGIALTYATWHISKSPELQRQLHAEVQSLKPSLMTDPKAASVITNTSALPDPKEVDSLPL
LHAIVTETLRLHAPIPGPQPRQTPKNGCSIGGYYIPGDVRIASLAYTLHRDKEVFPEPGEWNPERWVEEKTRKSPEDEVK
HREMQRVFWAFGSGGRMCVGSNFAMNEMKFILAFIYANFETSIVDDEGIEQEDAYTARPIGEKLVIRFTPLKT*
>CYP578A3 Fusarium verticillioides
92% to CYP578A3 Fusarium oxysporum = ortholog
FVEG_03904
MGLILVTALGLLPVFLIHRYIIYPVFFSALSRLPAPHWTCHISPLWILAARK
RRRENTSLYRAHQRLGPVIRIGPDEVSVDGLEGMRTIYQGGFEKGHWY
SVFDNYGVPNMFATGNSKSHSLRKRMISNVYSKSYIQSSQASKLQMAEILVSR
LLPALDGSLKSSHKSISTDYNDVEVFGLYLATAMDLITAYIFGLSNA
TNFISDEPYRRDWQDMYLARANYPFWTQEVPKLTSFCKRWIPWLKLYPQWVDQS
NKKLSDWNWELCENVRKTSKATRSPSSSQDIQRSDEPVVYNSLLAG
IDREFKTNGEKSILYTTSILQRDRAIASEVMDHSLAGQETAGIALTYATWHIS
KSPELQRQLHAEVQLLKPSLVINPKAASGLTNTSALPDPKEVDSLPL
LHAIVTETLRLHAPIPGPQPRQTPEHGCNIAGYYIPGDVRIASLAYTLHRDKE
VFPEPEEWKPERWISPTPGKSPDYEGKHREMQRLFWAFGSGGRMCVG
SNFAMNEMKFILAFIYANFETSIVDDEGIEQEDAYTARPIGEKLVIRFTPLKK*
>CYP578B1 Aspergillus nidulans
AACD01000016.1 revised
MFTHTAIFTLSFLLTVSFLLFIYLIHPLFLSRLSKLNIPNAHFTSPLSSY
WINSIRHAGLETVTIQALHAKHGPVVRLSPNELSVNSLHGLRVIYTGAFE
KHALYRDLFLNFHTENLVGMLGNKEHARQKRMLSRVYSKSYLQESEDMRV
ISAVILSTRLLPILQRIAENGETVNVLPLFQAVGMDFTSAYLLGVQNGTS
FLFDLPGWQRWLEEYEKFKHLSLNERADGFIERWCLDLCRQTQTESSSSD
AISTKPVVYNALRHGLEKSPDSRPSDLAIASELLDHLIAGHETSGITFTY
MMWELSHCPNLQDELRAELLLLQPSLKYPFPSGGGNGSFPHPSSVDNLPL
LDAIVRETLRLHAPASSPLPRVTPDTPGGTSIDGFDGIPGGITVSSSAYT
LHRIEEVYPQPTEWLPQRWLDPGSGKKHDMRRLWWPFGSGGRMCLGSNFALQ
(1)
EIKLVTAAVYTNYTTAVVDDEGIEQDLADFISLPKGRKLVLRFDPINRA*
>CYP578B2 Aspergillus fumigatus Af293
GenEMBL
XP_748713.1 also EAL86675.1
65% to 578B1
MFLLTIVAVSSFLVLLLYKILISPYFLSPLSKIPNAHFTAPISDYWIERKRRSGEEVLTIYNLHREHGPV
VRLGPNELSVNSLGGLHVIYTGAFEKHSFYRDTFVNFLTDNLVGMLPNDSHARQKRMLSKIYSKSYLHES
VDLRNASSIILSQRLLPVLKNAAEKGEAINVLPLFQAVGMDFTSAFLFGTANSTTFLFDLPGWKRWLVEY
ERFKTLSGKERYLGFIERWCLSLCSRVQSNEHPNDVPVATNPVVYSQLRQSLEKHPDQRPLDLALASELL
DHLVAGHETSGITFVYMMWELSKRPRLQAELRQELLTLSPSLRYPLVELGDGSLPLLPSPAAIDSLPLLD
AVVRETLRVHSPAPAPLPRITPSSSEGIAIEGYDRIPGGVKVSSSSYTLHRISEVYPQPFEWLPERWLDP
GPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYSNYTTSIVDDEGIEQDYAFISLPKGRKLML
KFTPVKL
>CYP578B2 Neosartorya fischeri
NRRL 181
DS027697, NFIA_006220
join(1665966..1667316,1667397..1667539)
94% to CYP578B2 Aspergillus fumigatus = ortholog, 66% to 578B1
name revised
from CYP578B4
MFLLTIVAVSSFLVLLLYKFLICPYFLSPLSKIPNAHFTAPISD
YWIERKRRSGEEVLTIYDLHREHGPVVRLGPNELSVNSLGGLHVIYTGAFEKHSFYRD
AFVNFLTDNLVGMLPNGSHARQKRMLSKIYSKSYLHESVDLRNISSIILSQRLLPILK
RVAEKGEAINVLPLFQAVGMDFTSAFLFGTANSTTFLFDLPGWERWLVEYERFKYLSV
KERYLGFIESWCLSLCSRMQSNEHPNDVPVATNPVVYSQLRQSLEKHPDQRPLDLALA
SELLDHLVAGHETSGITFVYMMWELSKRPQLQAKLRQELLTLSPSLRYPFVELSNDSL
PLLPSPAAIDSLPLLDAIVRETLRVHSPAPAPLPRVTPSSPEGIAIEGYDRIPGGVKV
SSSSYTLHRISGVYPQPFEWLPERWLDPGPGKIHDMRRLFWPFGSGGRMCLGSNFALQ
EIKLVMAAVYTNYTTSIVDDEGIEQDYAFISLPKGRKLMLRFTPVKL
>CYP578B3 Aspergillus oryzae
GenEMBL
BAE66519.1
62% to 578B1
MTSATAIAIGILLAAFVYKYLVHPYCLSPISSVPNAHFTSPISNRWIEKQRNAGKEVLTIYNLHQKLGPV
VRLGPDELSVNSLSGLKTIYTGAFEKHSFYSDVFINFQTPNLVGMIHNNPHARQKRMLSRIYSKSYLQES
RDLRDISKIILSQRLFPILRRVAKSGEAINVLPLFQAVGMDFTSSYLFGTKNSTTYIFHLPEWQQWLEEY
EKFKYMSVQDRYMGFIESWCLSLCRKVENNDQPNDVPIATNAVVYNQLRQSLEKDPDSRPLELAIASEVL
DHLVAGHETSGITFTYMMWELSQHPELQAELRRELLTLTPNLRSLPISDNAVDLPSLPSPSAIDALPLLD
AVLRETLRLHSPAPAPLPRVTPASPTGVSIEGYHNLPAGVRVSSSSYSLHRIEEVYPQSSDWLPERWLKP
EPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYTNFTTSIVDDEGIEQDHAFISLPTGRKLML
RFTPIKEA
>CYP578B3 Aspergillus flavus
100% to CYP578B3 Aspergillus oryzae
AFL2G_11839
MTSATAIAIGILLAAFVYKYLVHPYCLSPISSVPNAHFTSPISNRWIEKQRNAGKEVLTIYNLHQKLGPV
VRLGPDELSVNSLSGLKTIYTGAFEKHSFYSDVFINFQTPNLVGMIHNNPHARQKRMLSRIYSKSYLQES
RDLRDISKIILSQRLFPILRRVAKSGEAINVLPLFQAVGMDFTSSYLFGTKNSTTYIFHLPEWQQWLEEY
EKFKYMSVQDRYMGFIESWCLSLCRKVENNDQPNDVPIATNAVVYNQLRQSLEKDPDSRPLELAIASEVL
DHLVAGHETSGITFTYMMWELSQHPELQAELRRELLTLTPNLRSLPISDNAVDLPSLPSPSAIDALPLLD
AVLRETLRLHSPAPAPLPRVTPASPTGVSIEGYHNLPAGVRVSSSSYSLHRIEEVYPQSSDWLPERWLKP
EPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYTNFTTSIVDDEGIEQDHAFISLPTGRKLML
RFTPIKEA
>CYP578B5 Aspergillus niger
e_gw1.3.1489.1|Aspni1
56% to CYP578B3
MLSILLLAILPIIYLIHKYFTDPLSRIPPAHPLSPYTTKWITHHRDRTTEVKAIYTAHRARGPIIRLSPTELNVNSLEGL
RAIYTQGAFEKHAFYADTFMNFHTPNMVGMLENKPHGEQKRLLSGVYAKSYLLRSSDVKVLGREMVVGRLGEFLRGVVAK
GAVINVLPVFQAVGMDFTSGFVFGMQNGTRFLEDLTSWGVWLGQYEAFKSMSREERFMGFVERWCLGLCEGVGLSKQSGG
PVTQAVVYDRLREGLEEKKKVSGEDVDVNLAVASEVLDHLVAGHETTGITITYIMWELSKRPELQTRLRKELASLPGSLR
YTEGMEKGLPSLADIDALPFLDAIVRETLRLHAPAPAPLPRVTPPEGTWIHGYYIPGGVQVSSSAYSLHRIEEVFPSPEE
WIPWRWMDVKDDKIHDMRRLFYPFGTGGRMCLGSNFALLEIKLVIAMVYANFAPEVVDDEGIGQHLEFIALPKGRKLMVR
FVPV
>CYP578B6 Aspergillus clavatus
75% to CYP578B2
ACLA_060810
MSHFHLAVIAAGSLSALLLLFYKLLLSPYFLSPLSKIPNAHFTAPISSAWINRKRRHGQEVLAIYTLHRKHGPIVRLGPR
ELSVNSLAGLRTIYTGAFEKHAFYRDAFVNFFTENLVGMLGNRAHARQKRMLSKIYSKSYLQDLGDLRGLAAVVLARRLL
PVLRGCAVTRAAVNVLPLFQAVGMDFTSAYLFGTANGTVYVSDLSAWGKWLAEYERFKNATLRERYMGFIETWCLAMCRR
MQRNDHPNDVPVATRGVVYEQLRSSLEKDPDARPLELAVASELLDHLVAGHETSGITFTYMMWELSQRPRLQAELRRELL
TLTPSLQDPLVATSEGPVPALPSPAFIDALPLLDAVVRETLRLHSPAPAPLPRVTPCCPGGTTIEGYPHIPGGIKVSSSA
YTLHRIGEVYPQPLEWLPKRWLSPGPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYTNYSTSIVDDEGIEQD
HAFISLPKGRKLMLKFTPVEIRVE*
>CYP578B7 Aspergillus terreus
70% to 578B3
ATEG_07890.1
MAFPSLFTGAALTLLALLYKYVVYPYFVSPLAKIPNAHWTSPISARWIERRRAAGTEVLTIYNLHQQHGPVVRLGPNELA
VNSIQGLKTIYTGAFEKHPWYGDFFINFHTDNLVGMTHNQPHARQKRMLSKIYSKSFLQESTDFNAISRLILVERLLPIL
HRTARSGTAINVLPLFQAVGMDFTSAYLFGTKHGTTYVLQPEEWAHWLEEYEKFKYLSRQDRYGGFIETWCLHLCDKTER
NDTPNCVSAETTAVVYNQLYSSLVKSPDERPLRMAVASELLDHLVAGHETTGITVTYIMWELSQRPDLQKQLYQELSGLG
RCLEYSEDGEEIFRLPSATSIDPLPILDAIVRETLRLHAPAPAPLPRVTPMSATGTTIERYKSIPGGVRISSSAYSLHRI
PEVYPHPFEWLPERWLKPGPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVIAVVYTNYTTSILDDEGIEQDHAFISL
PKGRKLMLKLSPVKAE*
>CYP578C1 Aspergillus nidulans
AACD01000007.1 revised 7/18/07
MEVPVFAWIVPIMLGLTLLYEFVIYPAFLSPLSKLPNAHWTAPISPAWILWKRFRGQNNRT
IHAAHERLGSIVRLAPSEISINCVDGGIKSVYTGGFDKHEWYPRVFGSFG
(2)
TVSMFTMTGSKAHSTRKRMLSNIYSKSYLQSSRHLQLISKTIIFDRLLPILQAAAS
SKTDTDVHDLNQGLTMDFVSAYLFGLANGTNFLQNAEYRREMLRLYQCRK
PYEFYHQEVPNILALLKKIGIRLIPKWCDDANRILDSWGLELCDKAEASV
ASSDLSVEPVVYKHLKQAISKQAPLKIDDQKLYADYLEQQRLDIACEMYD
HLTAGHETSAVVLTYLMWELSQHIEVQKDLHKELLTLQPRIAPRCLSGHA
ELPSPKSIDSLPFLEAILTETLRLHASIPGIQPRVTP
TPTCTLVGYDNIPPNTRVNAQAYSLHRNPEVFPDPETWEPKRWL
KDCNKPSELEERKRWFWAFGSGGRMCVGSNLALQ (1)
KMKLVIAAIYTNFRTTIVNDDGIEAIDAYTVKPKGEKLILRFEYI*
>CYP578C2 AP007155 Aspergillus oryzae RIB40
71% to 578C1
MAGSPIVAISAIVLTITLLYKCIVYPVFLSPLSKIPNAHWTAPISPAWMLWKRFRSQNNR
TIQAAHERLGPIVRLSPSEISINCVEGGIKTVYTGGFEKHEWYPRVFGSLG (2)
TVSMFTMISSKPHSVRKRMLSNIYSKSYLQSSPHMRLISESILFDRLLPIIQEAVSSD
APIEVHDLNQGLTIDFVSAYLFGLANGTNWLQDAPFRRRMLHYYQGRKPYEFYHQEVPNL
VSWTKSLGIRLIPRWCDEANEMLDAWCLDLCDKAEQCLQSTEVSVEPVVYKQLQQAMIKQ
SSQKENTDESLKQQRLDIACELYDQLTAGFETSAVALTYLFWELSRHPDVQEELRA
ELLTLEPKILFPRSSASRGLPQAKAVDSLPLLEAIVTETLRLHAPIPGIQPRVTPYPSC
TLAGYSDIPANIRVNAQAYSLHRNPDVYPDPETWQPKRWLKGVNSDSDLEERRRWFWAFG
SGGRMCVGSNLALQ (1)
EIKLVTAAIYSNYRTSIVDDDNIEPIDAYTVKPRGDKLVLKFEAA*
>CYP578C2 Aspergillus flavus NRRL3357
AAIH01000684.1 100% TO A. oryzae
AFL2G_02113
1413
MAGSPIVAISAIVLTITLLYKCIVYPVFLSPLSKIPNAHWTAPISPAWMLWKRFRSQNNR 1592
1593
TIQAAHERLGPIVRLSPSEISINCVEGGIKTVYTGGFEKHEWYPRVFGSLG (2) 1745
1816
TVSMFTMISSKPHSVRKRMLSNIYSKSYLQSSPHMRLISESILFDRLLPIIQEAVSSDAP 1995
1996
IEVHDLNQGLTIDFVSAYLFGLANGTNWLQDAPFRRRMLHYYQGRKPYEFYHQEVPNLVS 2175
2176
WTKSLGIRLIPRWCDEANEMLDAWCLDLCDKAEQCLQSTEVSVEPVVYKQLQQAMIKQSS 2355
2356
QKENTDESLKQQRLDIACELYDQLTAGFETSAVALTYLFWELSRHPDVQEELRAELLTLE 2535
2536
PKILFPRSSASRGLPQAKAVDSLPLLEAIVTETLRLHAPIPGIQPRVTPYPSCTLAGYSD 2715
2716
IPANIRVNAQAYSLHRNPDVYPDPETWQPKRWLKGVNSDSDLEERRRWFWAFGSGGRMCV 2895
2896 GSNLALQ (1)
2916
2975
EIKLVTAAIYSNYRTSIVDDDNIEPIDAYTVKPRGDKLVLKFEAA* 3112
>CYP578C3 Aspergillus fumigatus Af293
AAHF01000007.1 chromosome 1 afu1_98, whole genome
74% to 578C1, 43% to CYP578D1, 46% to 578A2
1250155
MVVSIYTSLSIVILLLFVAYKAIVYPVFLSPLAKIPNAHWSAPVSPAWILWKRFRSQNNSTIHAAHE 1250355
1250356
RLGPIVRLGPSEISINCVEGGIKTVYSGGFEKHEWYPRVFGSFG (2)
1250548
TVSMFTMTGSKDHSVRKRMLSNIYSKSFLQSSPHMRLISRTIVYDRLLPILYDAAT 1250715
1250716
SSRPVDVHDLNQGLTMDFVSAYLYGVTNGTNFLQDAPYRQRMLHLYQSRKPFEFYHQEVP 1250895
1250896
NLLSWTKSLGIRLIPRYCDQANEILDSWGLGLCDKAEESLKSNRLEDEPAVYKHLKQM 1251069
1251070 ILKHLPENKNDVEYARILEQQRLDIACEMYDHLTAGHETSAVALTYLLWELSKRPELQDA 1251249
1251250
LRAELSTLEPMVIFPRPSESAELPPAKSIDSLPLLEAIVTETLRLHAPIPGIQPRVTPY 1251426
1251427
PSCTLAGYNNIPPKTRVNAQAYSLHRNPEVFPDPETWEPKRWLKDVNTPSELEERRRWFW 1251606
1251607
AFGSGGRMCVGSNLALQEMKLVVAAVYTNFKTSIVSDDNMEAIDAYTVKPTGESLILRFELVE* 1251848
>CYP578C3 Neosartorya fischeri
96% to CYP578C3 Aspergillus fumigatus =
ortholog
NFIA_020380 revised
MVVSIYTSLSIAVLLLFVAYKAIVYPVFLSPLSKIPNAHWSAPISPAWILWKRFRSQNNR
TIQAAHERLGPIVRLGPSEISINCVEGGIKTVYSGGFEKHEWYPRVFGSFG
(2)
TVSMFTMTGSKDHSVRKRMLSNIYSKSFLQSSPHMRLISRTIVYDRLLPILYEAATSNRPVDVHDLNQGLTMDFVSAYLYGVR
NGTNFLQDAPYRQRMLHLYQSRKPFEFYHQEVPNLLSWTKSLGIRLIPRYCDQANEILDSWGLGLCDKAEESLKSNRLED
EPAVYKHLKQMISKHLPENQNDVEYARILEQQRLDIACEMYDHLTAGHETSAVALTYLLWELSKRPELQDALREELSTLE
PMIIFPRPSESAELPPAKSVDSLPLLEAIVTETLRLHAPIPGIQPRVTPYPSCTLVGYNNIPPKTRVNAQAYSLHRNPEV
FPDPEIWEPKRWLKDVNTPSELEERRRWFWAFGSGGRMCVGSNLALQEIKLVVAAVYTNFKTSIVSDDNMEAIDAYTVKP
TGEELILRFELVE*
>CYP578C4 Aspergillus terreus NIH2624 revised 7/18/07
GenEMBL
AAJN01000108.1
58% to
578C1, 34% to CYP578-un1
ATEG_03775.1
MAVSAFTVVALVSLGLFVLYRVIIHPAFI
17000
SPLSKIPNAHWTAPVSPVWILWKRYTSQNNRTIQAAHEKHGPIVRLSPNEISINCVENGI 16821
16820
KSVYTGGFEKHDWYPLGFGSLG (2)
TVSMFTMTGSKPHSTRKRM 16641
16640
MSNIYSKSFLQSSPHMRLISENIVFSRLLPIFQDAASSGKHLEMHDINQGVTMDFVSAYL 16461
16460
FGLANGTRFLQDEAYRKKMLHLYHSRKPFEFFNQEVPNLLSWTKALGIRLIPRWCDDA 16287
16286
NDILDRWNLELCDKAEASVGSTELDAEPVVYKQLKQAMLKHTSKEDNQNS 16137
16136
VPDTPEKQRIEIACELYDQLTAGFETSAVALTYLFWELSQHPELQTKLREELLTLDPSIR 15957
15956
YPATSKILPSAKSVDSLPLLDAIVTETLRLHAPIPGIQPRVTPYPSCNLAGYTGIP 15789
15788
ANTRVNAQAYSLHRNPEVFPEPETWQPERWLKDGNSSAELEERKRWFWAFGSGGRMCVGS 15609
15608
NLALQ (1)
EIKLVIASVFTNYRTSIVDDDGIEAIDAYTVKPRSEKLVLKIEVA*
>CYP578C5 Aspergillus clavatus NRRL 1
NZ_AAKD03000006.1, 80% to 578C3
ACLA_030420
415154
MGVSTVTSLSIVSVFLFIAYKTIIYPAFLSPLSKIPNAHWSASVSPAWILWKRFRSQNNR 415333
415334
TIQAAHERLGPIVRLSPSEISVNCVEGGIKTIYTGGFEKHDWYPRVFGSFG (2) 415486
415548
TVSMFTMTGSKDHSVRKRMISNIYSKSFLQSSPHMRIISKTMIYDRLLPILYEAATSDTP 415727
415728
VDVHDLNQGLTMDFVSAYLYGLKNATNFLQDTSYRQRMIYLYQCRKPFEFYHQEVPNLIS 415907
415908
WAKSVGIRLIPRWCDQANEILDTWALGLCDKAEACLSSTKLEDEPTVYRQLRQTISKQLP 416087
416088
AKDDPESYAQNPKQQRLEIACELYDHLTAGHETSAVALTYLFWELSKHPELQKALREELS 416267
416268
TLDPKIVYPPPSASAELPSAKSIDSLPLLEAIVTETLRLHAPIPGIQPRVTPSPSCTLAG 416447
416448
YKDIPADTRVNAQAYSLHRNPEVFPEPENWEPKRWLKGINSPSELDERRRWFWAFGSGGR 416627
416628
MCVGSNLALQ (1) 416657
416708
EMKLTVAAIYTNFQTSVISDDNMEAIDAYTVKPRGEKLVLKFQTI* 416845
>CYP578C6 Aspergillus niger
e_gw1.1.562.1|Aspni1
75% to CYP578C5
MTPTVSACEDYTDSSTLHHGRTVSMFTMTNNKAHSTRKRMLSNIYSKSFLQSSPHIHLISETILLDRLLPIIQDAASSGS
PIEMHDLDQGITMDFVSAYLYGLANGTNFLQDEAFRCKILRLYQSRKPFEFYHQEVPNLVSWTKRLGLRLIPKWCDEANE
VLDAWGLSFCDKADECLSSTQLNTEPMVYKQLKQSISKQLPPKEAASYNKLIEQQRLDIACELYDHLTAGHETSAVALTY
LFWELSKHPDLQSALREELHTLEPKILYPRPSSSRDLPTPKSIDSLPLLDAIVTETLRLHAPIPGIQPRVTPSPGCTLVG
YSDIPGNTRVSAQAYSLHRNPEVFPEPETWQPKRWLKDCNPSEVLEERRRWFWAFGSGGRMCVGSNLALQEMKLVVAAIY
TNYMTAIIDDEDIEAIDAYTVKPRGEKLVLKFESVA*
>CYP578C7 Uncinocarpus reesii
61% to CYP578C2 Aspergillus oryzae
UREG_06580.1
MALVSPTVLAISAVCFLVVAVYKFIIFPAFLSPLSKVPNAHFTSSIAPFWILWKRFQMTGNRTIHEAHQKHGPIVRLAPT
ELSINCVDGGIRTVYAGGFEKHAWYPRVFGAFGTISMFSMVASRPHSIRKRMMSNIYSKSYLQTSTQLSAVSRKILFQRL
FRILEHHVKAVDQVEVHELNNAITMDFVTAYIFGLSAATNFLEDTTTRKQWLDAYQSRKPFEFYHQEVPNLVAWAEKLKL
PLIPSWCKKANDDMENWGLELCDKAEEHLSTADIESQPTVYKQLKMSMIKQLGLKNEKAVPEHMSNQLRMDIACELYDQL
TAGHETSAVALTYLYWELSRNPELQRELRKELRGLSPSINFPIHSETVPNLPSPKDIDALPLLNAVITETLRLHAPIPGL
QPRVTPSPMSSLGGYHQIPPNTRVNAQAYSLHRNLDVFPEPELWLPKRWLKPGDSPEMENMKRWFWAFGSGGRMCVGSNF
ALQEMKLVVAAIYSNYTTTIVDDDGIEAIDAYTVRPTSNRLVLEFHRADI
>CYP578C8 Coccidioides immitis
78% to CYP578C7 Uncinocarpus reesii
CIMG_04972.2 revised
MALLSPATLAIITVSALAAGVYKFIIYPALLSPLSKIPNAHFTSSISPLWILWNRFRMRG
NRTIHEAHNKYGPIVRLAPGEISVNCVDGGIRTVYAGGFEKHDWYPRVFGAFG
TISMFSMVGSRPHSVRKRMMSNIYSKSYLQGSPQLAAASRKILFQRLFPILERHVERADQ
VEIHELNNAIT
MDFITAYIFGLSAATNFLEDAQTRKQWLEAYQCRKPFEFYHQEVPSLVAWAETVKLPLIPSWCQKANDYMESWGLEICDN
ADKYLLTTVVESEPTVYKQLKMSMVKQLPSDGVKSLDEETSKKLKLEIACELYDQLTAGHETSAVALTYLYWELSKDPEL
QCELREELRGLSPSIDIPANADIMPDLPSSKDIDSLPLLNAVVMETLRLHAPIPGIQPRVTPSPTCSLGGYDGIPPGTRA
VSAQAYSLHQNPNIFPEPESWLPRRWLKQNDVSEMES
MRRWFWAFGSGGRMCVGSNFALQ
EMKLVVAAIYSNYTTSIVNDDGIEAIDAYTVRPTSNRLILKFGRA*
>CYP578C9P Histoplasma capsulatum G217B
pseudogene
ABBT01000030.1 Ajellomyces capsulatus G217B
99592-98639
51% to CYP578C7
HCB00216.1
AVIAVGILLPCLYK*FLYPVFISPLSKIPNTDISAPASPAWI
&
RFRMQGNRTIYKAHQKYGPIVRLEPLEISVNYVDIRIQTVYAGGFEKHDWYPRVFGAYGYVICFDFSASVERPTEGTKPHSVQ
&
ISQAIICRRLLPVLQRNIQFQANVEVHGCINAIAMDFVPAYIFGLASGTNFLEDIPTARDWLRVYQSRMPFEFFYQVPRMTYLAK
MLKIPLISNWSDKANQVMENWGLEMIDYAEKFLASTDSACEPVVYKQVKQSMLKQ
&
TLKSLKxxxxxxxxQQRLELACEMLTILPLIMKVAQLPLLIFTGSY*GILICR*SFE
ELETLSPKIIAQSVLEIPTELPHPKAIDDLPLLG
AIVMETLRLHSPIPGIQPPITPAPSTTLAGYDKIPRKTRVNVQAYSLHRNHDVFPNPGSFLPDRWLKPMDSVELGNMRRW
LWAFGSGGRMCVGSNLAPQ
SEIKLVVAAIYSNFTSKIIDDDGIDPIDAYTVRPSNNRLVLKFERV
>CYP578D1 Nectria haematococca
e_gw1.19.155.1
Necha1/scaffold_19:640595-642276
38% to 578A1 Magnaporthe grisea, 49% to 578E1
in CYP53 clan (part D)
MTSLNIPAVAAALVLLVIVYERIIKPAFLSPLAKIPAPHWSCHVAPFWLWWAKLTHRENGLVYKNHMAKG
KALRLSPGLVSLNCFEGGLKQVYLGGFPKTEFYWRGFANYG (2)
THNIFTFEDNATHSARKRIISGTFSKSFI
LADATSQASMKKILFGRLLPKIDAAAKRNEALEVLELFYSYSMDSFVTWQFGSKLSSNLIEDEKERRLYL
DGFFAAAPYTFWQYEFPRLSSWMKLLGIIPKKVDRGFHDIEQWNLEKCDKAQELLAQGEDKLSDEDKPVV
MSLALKAMSDLHAESRQYPQRLDIASDMFAHNSAAHETSGNTLTYCFYEMSQRPELQAKLRQELLTLDPP
LYFPPPDGGELVLPEPKIMDKLPLLEAVILESLRLYPSVPGGQPRRVPKPCSLGGYDGIPAGTTVQCYAY
SLHRTPEIFPEPDEWKPERWIDSSPEQLSQMRRWFWAFGSGGRMCIGSNFAYF (1)
SMKNVVGSVYTNFTTSLHDHGSMELEDAYLAGPAGHRLEIKFTRVEK*
>CYP578D2 Fusarium oxysporum
87% to CYP578D1
FOXG_16972
MTSLNIPAVAAGLVLLLAFYERIIKPAFLSPLAKIPAPHWSCHVAPFWLWWAKLTHQENKLVYKNHMAKGKALRLSPGLV
SLNCFEGGLKQVYLGGFPKTEFYTRGFINYNTENIFTFQDNGTHSARKRIISGTFSKSFILADSTSQASMKKILFGRLLP
VFSRAADSKKPLEVLELFYSYSMDSFITWQFGSTLSSNLIEDEKERRLYLDGFFAAAPYTFWQYEFPRLNNWLKTIGLIP
KKVDSGFHDIEQWNLEKCDKAQELIAQGEEDLSDADKPVVMSLALKAMSDPHAKPGQYPQRLEIASDMFAHNSAAHETSG
NTLTFCFYELSKRPELQAKLREELLTLDPPLYFPPPAEGEWVVPAPKAIDKLPLLEAVILESLRLYPSVPGGQPRRVPKP
SSLGGHDNIPAGTTVQCYAYSLHRTPEIFPEPDQWKPERWIDSSPEHLATMRRWFWAFGSGGRMCIGSNFAYFSMKNVVA
SVYTNFTTTLHDHGSMELEDAYLAGPVGHRLALKFGYIRKM*
>CYP578E1
Nectria haematococca
e_gw1.53.20.1
Necha1/scaffold_53:74141-75808
48% to CYP578D1, 46% to CYP578C3, 39%
to 578A2
This gene model seems correct
MTLNIPLIAAVAALVLGLYKLVLYPLFFSPLSKIPTAHWSSHVCPLWIYYIRYKNVENQTIHELHKTKGP
ILRTAPSQLAVSCYEGGLKTIYTGGFHKTDFYHNRFINYG (2)
VDPMFAMSGKPHSDRKRMLSHVYSKSYILA
SPTVRETTRAVLFDRFMPIIKSSADSGKPLEVLEILAAYSMDAFMTYQFGLSLGSNFLQNAEERKWYLDT
FYVRRPYLFWTTELPKLTSHLRKIGIKLVPDWVERSTIDLEDWQMRFCDKAENLLAADTRIAAEDNPVVY
AWERSAFKKQDGKNQVLNGQAYPRRLEIASDMYDHNAAAHETSGDTLTYVFYELSRRPEHQDRLRQELSN
LSPPLEYPNAPDELPDPKSVDQLSLLDAILQETLRLWVAVPGGQPRVTPSPSCTLAGYANIPPGVRVQSH
GYTIHRNPEVFPEPDEWIPERWLNQTPERLSEMRRWFWAWGSGGAMCIGSNIATH
(1)
SMKHCIAGVYTNYKTTIVCAPDMELAEGFTAGPRGGKLELSFQPV*
>CYP578F1 Aspergillus niger
e_gw1.1.426.1|Aspni1
46% to CYP578C4
MEASILPSVPACAGVALVAFFLYHFIIYPSFLSPLAKIPNAHPLAPYTSLWILWARYRIRENNTVLRAHQQHGEVVRLAP
NEVSINCVNDGIKTVYGKGFEKPPFYSVFVNYGALNMFSSLHSPEHAMRKKRISNIYSKSFLQSSPDAAAIIQEVVQRRL
LSQFASHAKSKQPLDIYPIYKATAMDLTTSYFFGLSAGTQFLIDPTAAARWQELYLDDQHPARHLAHDQIAAWCLNMSDG
AEKMLAKKAGGSSLPPGHLPVVYERLRQSTEKEGMSPQQLQVTSELLDQLIANNGTVATTLLYVTWQLSQNSAALARLQE
ELRSKLGPEAFAWSASKEEDTLPKAKDVDELPYLNAIIMETLRLHAPVAGSQPRITPENNKTTLGQYENIPGGVRVSAAA
WSLHRNPAVFPRPDEWHPERWLSENLEGADKKERWFWAFSSGSRMCIGSNLALYLLKYVVAAIYANFRTHIVNDEGIEQE
DGFISGPKGNQLTVRFESITVD*
>CYP578G1 Mgr041 Mycosphaerella graminicola
42% to CYP578C4 Aspergillus terreus, 43% to 578A2
MALPIIPLLAALFLLAHLLHKHILHPLFLSPLSSIPPAHWSSHFSSLWILSHRHSQSDTFAIHAAHTRLGSIIRLAPNELSVNSVNRGIRTIYAGGFEKGEWYSEGFANFGVPPMFGMHGAREHGRRKRMVSHVYAKSTLQGSEALGGITKVLVERLRGRLSEAAKT
GEQVEMYELFAATMMDFVTGYVFGLGQGTDFLREEKRAREFFKGFKERQRFTFWAQ ECARLMRWVGWMGLRSWFVPKWVDESNEESERWVLEMCDRAEEVVQRQEAGVKKTESKDTPIVYAQLRQSFIKEARKDTKDNPSTTSILQSSHLDLASELLDHVLAGFDTSSITLTYLAWQLSRPSNAHWQSRLRTQIATLNTSL
(short in this region)
DAKLIDNLPILHAVLMETLRLHAAIHGIQPRLTPEGLSSLGDPEAGLVVRDVPGGARVQSQAYSLHRNPEVFPEPEEWRPARWLPSSPASETKVEYEARQREQLRWFWAFSSGGRMCVGSHLAMLDMKATIVAVWGRFDTAIGDDEGMKGVNGGYMAEPLGVFDEEDGQRKRFLRLRLKEL
>CYP578G2 Mycosphaerella fijiensis
54% to CYP578G1 Mgr041 Mycosphaerella graminicola
one frameshift = &, possible seq error
estExt_fgenesh1_pm.C_260019
MTLPTIPSAAGVALLALAIYKYIIYPAFLSPLAKIPNAHWSASISPLWILYHRHQQQDTFVVHACHSRLGPIMRLAPNEL
SVNCVDGGIRTIYAGGFEKGDWYSNVFSNYGVEPMFAMEAHGPHSKRKRMLSNVYAKSSLQNSAALTKITDVVIKERLIP
RLQKAAKSGEAVELYDVFSAVTMDFVTGYIFGLRNGSNFVQDYA &
RWRPALPRIKARQKYTFWPQ
ELPNVTSWLKRLGLKWLVVPTWVDSANFDIESWVMSMCEQAEKTCKRIEQGEDVAPEDTPTVYTQLRNTLLK
DDHNPPASDHRLTLASELLDHTLAGFDTSGITLTWLAWQLSKPVHKTWQHRIRHEISTTPLSSPSHHPLDAKTIDNLPTL
HAILMESLRLHPAIPGNQPRLTPPNTTLAHIRNLPANIRVQAQAYTLHREPSIFPSPEIWDPNRWLLLLSPTTEKNLHRW
FWAFGSGGRMCVGKNLAILDLKAAMVGVWGKFETEIVEDRGMVANGGYMGEPLGVGVDGDGERRRRKFLVVRVREVDV*
>CYP578H1 Uncinocarpus reesii
38% to CYP578C3 Aspergillus fumigatus
UREG_04195.1
MLLLAGSLFAIVVVVYKKIIYPLYLSPLAKFPSAHPLASISSLWIQWKRLTDKEFDAVVCGFRQKGPYLRLGPNEVAVNT
MERGVRNIYGVGSDNFDKSPWYNFFKNHGFRNTFCALGSEHAVHRRRISGVYSKSFLQSSPHIRTILDTVIQGRILPILA
RKAKDEETVDILALNLAYGLDFVSAFIFGLPRGVKFLEDRASREHWLELYDRTHPKSLFWLAEYPVLAQVASKFGIPLVP
KGFPKAKRELETWALKRLKLAEDVLAENPTDDTIRPGDMPLLYHALKAGMETEQGKKKNGRFVPNNTQRHELASECLDHL
VATRDTFGITFSFVILNLSRNLEVQEQLRAELRSMTRPFRYHDEKKTEIPAPQALESLTLLNAVIKESLRLRNTGPTLNP
RITPKGRKVTLGPCDDIPAGTRVGAYAWCLHRNEEGYPSPTTWDPTRWIVDASDPKAGERDRWFWAFGSGSRQCLGQNLA
FELMRFAVAGIYTNFKTSIVDDSAFVGDETFVTGDGSEQLILKIERLEN
>CYP578H2 Coccidioides immitis
81% to CYP578H1 Uncinocarpus reesii
CIMG_06188.2 revised
MLLLAGTLFTLAFVIYKKILYPLFFSPLAKIPSAHPLASVSSLWIQWKRLTNKEFDAVVSGFRQKGPYIRLAPKEVAVNT
MECGVKNIYGIGNDNFDKAPWYNFFQNHGFRNTFCALGSEHALYRRRISGVYSKSFLQSSPHIRAILDAVIQQRILPILA
RTAEKEEPIDILALNLAYGLDFVSAFIFGLPRGVRFLENTASREDWLDLYDQTHPSKNMFWLTEHPVLSQVASLFGIPLI
PRNFLKAKRELENWAMKRIKLSEDVLSNNPTDETISPGHMPLLYHALKTGIELEQGEKRNGRFEPNNIQRHELASECLDH
LVATRDTFGITFSYVILNLSRNLEIQEQLRQELLSISQPFRYHNEKRTELPTPQTLEALPFLNAVIKESLRLRNTAPTLN
PRITPTGRKVTIGPCDNVPAGTRVGAFAWCLHRNEEGYPNPRTWDPMRWIVDSSDPKAGARERWWWAFGSGSRQCLGQNL
AFELMRFAVTAIYTNFRTSIIDDSAFAGDETFVTGDGSEQLILKIERVET
>CYP578J1 Mycosphaerella fijiensis
39% to CYP578G1 Mycosphaerella graminicola
32/33 top hits are ALL CYP578 SEQS.
gw1.9.589.1
MALLVLAAAVLAAAALYHFILYPLLWSPVASIPAVHPLAKISSLYMLWIR
YWDDENDTVFAAHEKYGQVVQLGPQELSVNCIDDGIKTV
YGKNFDRHYFYRVYEDCGRHNLSSSLDATSHAIRKRRVTHIFSKSYLYTSPALSGLLNQIIRYRYLPLVIGYAMEQQPFD
TMILFSALAIDVVTGYTFGTKAGTNFLNDRTQH
AKCIHEIHKGRPYPMMFWLHEFP
GCISFLESIGFLSKERYKSL
EALHMFCLDMCDRAENALADPGSDNTAPEEVPTVYQQFKYTLDKEGLSSTPSLKVLEGHRPISCSPQQLEIAAEVCDQIHASDE
TLAITLTYAVWELSRNVDLQQRLRRECQALGPDIRTDSSASLPAPSLVDSLPLLHAVVMETLRVHPTVAGGQARVTPYGK
LSKLGRYENIPGGYRVQSYARFLHANPAVFPDPNVWQPERWLHSGAKTDLYGPDEKLRWFWAFSSGARMCLGSHLALLVT
KYVLLFTYSNFETYVVNDEGIEHMKGYVGGPKSGKMM*
>CYP578-un1 Aspergillus oryzae
BAE55033.1 AP007150.1
29% to 578C1, probable pseudogene, last exon may be wrong
MTQWIALLLVAICG
YLALRLRSSSLSKIPAAHWSARFSPIWILWKRYTGKELHTLVDAHQKHGSIVLVGPQD
LSVSCYQDGIRRVYDSGYPKPAPFYSMFNYYR ()
QQNAFTSLDRSEHGLRRRRTAALYSKSAL
1613568
MQSQHLRDITRSITYDRLLPKLNSVAQGNGRIDGLDLSYCICVDYLSSFIFGYSNGTNYLSQPKSAIDVW
RFHYENLMCQESFFVQETPSLYKLLRYISIDLLPRKYTESADFLGRWMSDMASKADRATDRKRSTGLPLA
LEDEPVVYDMAKEAVRKDSPHLSEGDQRKQVASEMFDHIC (?)
Missing I-helix motif here, 7aa
LVLGYAFWYLAQHPDAQQRIQTELNSQGID
MRSRETVTNSSKRPRAVELDSLPYLRAVIDECLRMRPTSTPLPRITPSNRKVSVAGIDGIPPGTRINTFQ
1614560
WFVHRDPQKWDNAHDWNPDRWLTRGNTDNKNEREDVLWAFAS
GPRMCLGNNWTYY (1?)
LTTLNSTAMQHILATICSSFNFTALPREENQCWPGSPEDELPIRVCLRN*
>CYP578-un1 Aspergillus flavus
99% to CYP578-un1 Aspergillus oryzae
MTQWIALLLVAICG
YLALRLRSSSLSKIPAAHWSARFSPIWILWKRYTGKELHTLVDAHQKHGSIVLVGPQD
LSVSCYQDGIRRVYDSGYPKPAPFYSMFNYYR ()
QQNAFTSLDRSEHGLRRRRTAALYSKSAL
1613568 MQSQHLRDITRSITYDRLLPKLNSVAQGNGRIDGLDLSYCICVDYLSSFIFGYSNGTNYLSQPKSAIDVW
RFHYENLTCQESFFVQETPSLYKLLRYISIDLLPRKYTESADFLGRWMSDMASKADRATDRKRSTGLPLA
LEDEPVVYDMAKEAVRKDSPHLSEGDQRKQVASEMFDHIC (?)
LVLGYAFWYLAQHPDAQQRIQTELNSQGID
MRSRETVTNSSKRPRAVELDSLPYLRAVIDECLRMRPTSTPLPRITPPNRKVSVAGIDGIPPGTRINTFQ
1614560
WFVHRDPQKWDNAHDWNPDRWLTRGNTDNKNEREDVLWAFAS
GLRMCLGNNWTYY (1?)
LTTLNSTAMQHILATICSSFNFTALPREENQCWPGSPEDELPIRVCLRN*
>CYP579 # name changed to CYP58
no sequence.
>CYP580A1 # name changed to CYP542B1
no sequence.
>CYP581A1 Magnaporthe grisea MG02094.4 poor match AACU01000401 cont2.392
MSIPIATIASAVLSLRGLTWVAFIFLVSYCIYSLHIKPLLSPLRHLPAPK
QGFLWFRLLKEPKAVEIERWMDELPHDGLFRYYGIFNRQRIFTASPKATA
DLLHGPNAFKYIKPKLQFILANNIAGKGLLIQEREENKHARKGLIPAFNP
DQIRKSFPDMWKTAVETIEALPNYTEKMALGDNGCNSTEVVELLKLISAA
SIDIIGHFAYSTDFKAIQINAPKYKRHALKSPNSIFARAYVEMFKTTWRG
QRSLEAASLIGANIALALPLRAVKTIKSIMALVWQVSENIVTEHERAAEY
QNGRDPRGHAQRGDAVRGLSHRDLVTQTVHFLAAGTETVAGSASWAVHLL
SRHPEMQTRLRDEVRAAIPDPNAPQQQATLRSLSYLGAVVQEVLRYHSIN
TLLWRECVDPTASEICGVYIPKGTVVVFSPWAMNRDPKSWGPDARTFNPD
RWLGPADQQEKHRRHPCSFLTFGSGPRRCPGEPYARDELLCLIASLVGRY
HFSPLRPEAESDEGQEIGDDFALTLFKIYEGWRLMVTRVPGW*
>CYP581A2 Gibberella moniliformis 7600
AAIM01003085.1 cont2.3085, whole genome shotgun
64% to 581A1
ERNVEKYVARSDPDMLTLLMQTGHF
77
SHQDLVEQTVHFFAAATETVAGSTCWAIHLLSRHPDIQDRLRAEIREHITSPRSDVSQSQ 256
257
LHSLKYLNAVTNEVLRYHSINTLLWREPTQDITLAGEPIPKGTKIVFSPWALNRDPA 427
428
HWGPDARLFNPSRWLDNPSGGADHAYSFLTFGGGPRRCVGEQYARDQLSCFVASLVG 598
599
RYKFTPVDLQNGSDEGREIGDDFALTLFKILSGWKLNVEVVPGW* 733
>CYP581A3 Fusarium oxysporum
91% to CYP581A2
FOXG_12902 revised
MSLSTYLTKPSWIFPILAIVATVLHCINRLFIKPHFSPLKHLPSPKQGPFLFRLIHEPKVSEIETWMDELPHQGLIRYMG
VFNEERIYVASPEAAQELLSSNAYKTIKPELQWILANNIAGHGLLIQEGDQHRQARKRFNPVFSPAQMKKWFPTIWTLAI
DAIDLLPQHIKREPFAPHGVVGIIELVSAASIDIIGRFGFSTEFQTLQRVTSGQSTKGSSDPKVRFGKAYIEMFKTTKRG
QTTLRAASLIGPQIALKLPLRAVKTIDSIMALVRATAEDITTDHERNIEKYVGSPDPDMLTLLMQTGHFLHQDLVEQTVH
FFAAATETVAGSTCWAIHLLSRHPDMQDRLRAEIREHIVSSRSEVSQSQLHSLKYLNAVTNEVLRYHSINTLLWREPTQD
ITLAGERIRKGTKIVFSPWALNRDPAHWGPDARMFNPSRWLDNPSGGADHAYSFLTFGGGPRRCVGEQ
YARDQLSCFVASLVGRYRFTPVDLQNGSDEGREIGDDFALTLFKILSGWKLNVELVPGW*
>CYP581A3 Fusarium verticillioides
94% to CYP581A3 Fusarium oxysporum = ortholog
FVEG_11655
MSLSTYLTKPSWIFPILAVVATVLHCIKRLFIKPHFSPLKHLPSPKQGPLLFRLIHEPKV
SEIEAWMDELPHHGLIRYMGVFNQERIYVASPGAAQELLASNAYKTIKPELQWIL
ANNIAGHGLLIQEGEQHKQARKRFNPVFSPAQMKKWFPTIWNLAVDAVDLLPQHIKREPFAPH
GVVAIIELVSAASIDIIGRFGFSTEFQTLQRVTSRESTKGSSDPKVRFGKAYIEMFK
TTKRGQTTLRAASLIGPKIALKLPLRAVKTIDSIMALVRATAE
DITTDHERNVEKYVARSDPDMLTLLMQTGHFSHQDLVEQTVHFFAAATETVA
GSTCWAIHLLSRHPDIQDRLRAEIREHITSPRSDVSQSQLHSLKYLNA
VTNEVLRYHSINTLLWREPTQDITLAGEPIPKGTKIVFSPWALNRDPAHWGP
DARLFNPSRWLDNPSGGADHAYSFLTFGGGPRRCVGEQYARDQLSCFV
ASLVGRYKFTPVDLQNGSDEGREIGDDFALTLFKILSGWKLNVEVVPGW*
>CYP581A4P Mycosphaerella fijiensis
45% to CYP581A1 Magnaporthe grisea
N-term not found
fgenesh1_pg.C_scaffold_12000008
LQFVLAQNIASNGLLIQEGEAHKKARKALSP
AFSPAQLRDLHPIAFRTSLEMLERLAGEVNKHSTESVSGGSSTAGEVTPVNILHG
TTLDIVGRWAYSVDFGVVTDPKSLI
RPYIGMFKQSWRGQMTFNVAAVIGPRLALKLPLRAVKTMGAVMKPVHDMSADIVAQH
xxxxxxxxxxxxxxxxx
RG*GSARLDQ
ESLVDQTVHMLAAATETSAGTLSWAVHLLSRYPDWQNKIREEVRRRLPSPRCMN
LEECSSAVQRSDFQDMVHLNAFVKEVLRFHSVNTLLWRECIEPATIASETIQPGTIVSFS
P*ALARDPKVWGPDARTFNPQRWIDDSQGGSRNEAAWLIFGSGPRGCIGEQYAYAQIQAI
IATLVGRYDMSPLNAAVGTDEGHELGDDAALTLSKVMDGWKLKFREVPR*
>CYP582A1 Magnaporthe grisea MG04911.4 poor match AACU01000762 cont2.921
MDIQTCAVLSALETVAWVGFHEYRSLALTTRKELVAVFSVFFLVQYLCAK
IYRIFIYPVHVSPLRHLPTPKGNHFMLGQLVNQFRASCPNELYLKWTSQW
PDSPFVRFFTIGNKESLLINGIEANREVFATHCYAFTKPSLFLRFVGDIA
GTGLLFTEGDEHKRHRKMILNVFSVPNLKKMFPIFQEKAEELSQHLDATI
AASTGGSIDVQCIYSKATIDIIGITALGLDLRNLKSTKLRMDFLQCYRRM
HEQPFSAALISFINVHVPIRRLLWFVRANRDFVEASQEVRAMLRTCIRER
IRDVDSRKGAEVKFQSRDLLTYMVEERLLAQCKDPLTTEDILGHLLNFLS
AGHETTTGVMTWASYVLATNPRIQDRLRAEVEALLKESPCPSYSDIERMK
YMHNFVREVLRLYSPAVATYREAAKDVTICGTLIPKGTHLVLCPSVCNKS
KRIWGADAEEFVPERWEKLDGEAASPYSIMTFLAGPRQCIGKQYALQEVK
VLLIEVISKFRLLPTEELVSNDFKVNISNPGVVLRPKGGMVLRVERL*
>CYP582B1 Phaeosphaeria nodorum SN15
AAGI01000073.1 cont1.73, whole genome shotgun sequence
39% to 618A1, 41% to 582A1
198750
MYLETCAALSLAELCMLMLMHGVPSMYNVVCSYLVLFSLQYASINLYYTFIFPFY 198586
198585
VSSLRYMPGPKNHHFFIGHALNQFRANGPYELYLSWSRQWPTAPFIRYISFANTETLLVN 198406
198405
SLRAHQEVLSTKCYSFVKPPFFARIVGEVTGMGLVFAEGEDHKRQRKMLN (1?)
GIFSTPNMKKLLPVVQRHGKRLTETIDQRIGSESSAVVE (1)
198045
VVSLFSKATLDIIGLITLGKELDCFTAKPTFHECYDLIFNQSSLSAIITAVNTYIPL 197875
197874
RSWLPLEANRSFVTANDEVKRILRQQIRLRQKEIATARTSVKKSSLPISRDVLMYLLEA 197698
197697
PPSRQQQWTEDELLGY (0)
LLNFMSA (1)
197535
GHETSATTLTWAVHVLSTRPDIQTRLRNEIMTLPSCGEPDYTQLEGLRYLHNFCREVLRVYAP 197347
197296
AVMIWRQAAEAVIIENTYIPAGTNVIVSPQVSQSHPEIWGSSATAFEPDRWDSLPPESAS 197117
197116
PYAFQAFSSGPRVCIGKGLAMLEFKSLLVDIVRKYTFEAVEGKLVLENYLTL 196961
196960
RPKGGFRVRFKIAGEDIAQRAD*196891
>CYP583A1 Magnaporthe grisea MG05787.4 poor match AACU01000820 cont2.1083
MTSIWSLSSALGHILAIIPDVTHLLSVLLVVILQICLKVSFAPARRPDLS
NIPGPWYTRVSHMWFFYQRWHGRLAPASHAILLSHGDETNGIVRLSPTVV
LLNDMPSLKTLFGKQDAATGTKIVRALNLGGHSWSIMAPEFDLARGRRQA
VQAATTETNMRLWRGALEREVEVLLGALRSGGAVDVVRPLRMLTTKASAL
ALAGTEISDATAHEVLEANGLFNRCVANRLCMPDAILSMLDMLPWREHLL
SHTGLFRTLGSGAKLFTLGEKLNDLAAAKGSNLQVQSSALYLQRKQMRIE
DGVEDTDLLSADTAGGLLAGSETTAATLAWILFELSRRPELAERLRNELT
AADGTTTGADLLDAVIKEELRYRGPVALTSNRIVGAGGATVLGGRYFLPA
GTVVVMHNHSLSRRDPRGSHHVWDPMRWVGAGVGGADAADRCTAPFGFGI
RRCPGKTMAWMVMRKVVAAVVKGFVLQCPAETTDETMEAVELNGNRPRKE
ECRLMFFPRDKSQVA*
>CYP584A1 Magnaporthe grisea MG08956.4 44% to 52A1 40% to 52F1 AACU01001733
cont2.1681
MSLSTIIAQVALALIASVWIWRSITLYYRRRKLKLLHGCMPVTKIPDWDP
IFGLGFTYTLIKSDINNHRLINNTVERLQTYGYTHMANVMRHRMFFTCEP
ENLKAIMHGQFDHFDNELRSVPAGHFMGMGIFLADGEKWQRSRALVRPNF
ARDQVADLGSLERHFQILLSIIPKDGSAVDLAPLFFAFTMDSITDFLFGE
SVKALQAHASGAHASSSPWSQKGIEQFAEAWEYAQNDMLFRFILGPARYV
YQDKKANQCVKMIHAHVDRYVEQAVRFRNEELARGGDEKEPKSEGRYIFL
QALAKQTQDRKVLRDELMNLLMAGRDTTAALLSNLFHTFARRPDVWAKLK
NEVMFLEGRLPTYEDIRNMKYVRWCINEFGILGKQASFDTTLPRGGGPNG
RSPIFLPKGSIVLYSMLAQHRRKDLFGEDALEFRPERWETLRPGWNYVPF
NGGPRICVGQQYALTEASYLVVRFVQTFATVESRDPEPWSIGKRLLTCPM
NGTIVSLSR*
>CYP584A2 Magnaporthe grisea MG05908.4 40% to 52F1 AACU01000839 cont2.1108
MFNLISSLKVGAALVAAVWIWQRIMLYNHRRKIKRDSGCLPAAKFPDWDP
LFGIGFTYHMVTEDILDFQIMKNTADCLEKYGNTFTSKAMGFNFIWTCEP
ENIKAVLSTQFDQFNNQGRSVGAEDFLGKGIFVSDGEHWQKSRALVRPNF
ARDQITDLVSVEERFQTLISLLPKDGSTVDLLPFMFDFTMDTSTHFLFGD
SVKSLEANAHERSIGHHGQENLDEFSAAWDYAQNDMLSRFVLGPLRYVYK
EKKAARCIKLVQDHVEKYVDEAIRYNSQVRAAGGDEKKEPEERYIFLRAL
AKQTQDRRMLRDELLNILVAGRDTTASLLSNMLHTMANRPDIWTKLKNEV
AFLQGRIPTYEDIRNMKYMRWCINESLRLHTVLALVGKEASIDTTLPRGG
GPDHKAPIFVAKGTFIAYSFLALHRRKDLFGEDAHEFKPERWETLRPGWN
YLPFNGGPRICVGQQYALTEAQYVLIRFLQTFSAIESRDPEPWSIGNRMT
TCPKNGVQVSLRC*
>CYP584B1 Magnaporthe grisea MG08494.4 42% to 52F2 46% to 52E1 AACU01001266
cont2.1600
MGVQDFANLFLGGRFSGSVTTAAMLLFLVVVLVVSGVRSIRSISARRRFI
AENNCKPAPAWPQKDPILALDFILKGLANFKQKKFLDGWTKYYEDLGPTF
TTKSAGMLYINTIDPENIKTVLATRFRDFSLAERVEIMGPLLGRGIFVTD
GDEWAHSRALLRPNFAKEQVADLGMIDRHFSDLMALLRPHAADGTTVALQ
PLLMRMTMDTATEFLFGQSTRTLSVEQADSAGNAFSRAFQFSLNEMAHLF
RLGPFRILRRQSRELKDSHDICRAYVDGFVDEAWAWKQGGKTDGRTNFLR
DLVESTDNKQKVRDELLNILIAGRDTVASVLGSLFRVLAQRPEIWAKVRA
EVAQFEGELPRYDQLRDLKYAKYCINEALRLWPAVPLNGRLAVRDTVLPR
GGGPNGDEPVYVPKGSLVNYSVYSMHRRTDFYGADAEEFRPERWEGKIQG
WQYLPFNGGPRICLGQQYALTEMLVVLVRFAQEFSHIESRESTPWQEELH
LTVQPANGVQVALTAANTA*
>CYP584C1 Magnaporthe grisea MG03821.4 42% to CYP52F3 AACU01001030 cont2.747
MTPQGLLAVCTGLLLLKIFISFVSRYRRHQILIRQHGCLPPPKAKLKDPI
FGIDVILSNGRAAREHRSLQTFEERFYSIGATYSTKHGFPLIITMEPDNV
RAVINQNFHDYALAPFRQPALKHFLGDGIFTTDGEKWHSSRALLRPNFNR
DQIANLEAIETHVKDLFALLPRDGATPVDLKGLLLRFTMDSTTEFLFGQS
VYSLRRNGARDGDSLEAQFETAFTGAQAECMEFIGMGPLARFARVNSQKQ
VEIVHRYIDKFVDRAIAFRKEYGKQGHRSESSLTGFVPGPAYSQPGYPCH
AFRKEYEAGGGGPIGTGKEKPKYLFLQELAKQTTDRTRLRSELLNILMAG
RDTTASLLGNLFFMISKSPEIMAKLQQEVDSLNGARPSYSSLRDMKYLKY
CLRESLRLHPVAPVNTRIAVTDTVLPRGGGPDGSKPVLVPKGTAVGWSVY
AMHRRKDLYGPDADRFRPERWETLNTRSEYLPFNGGPRICLGQQYALTEA
SYVTVRMLQEYEMESRDPGEWEEELAITACNRRGCLVALKARSE*
>CYP584D1 Fusarium graminearum FG08320.1
AACM01000333 FGcontig1.333_scaffold5
MFSLLFLQFFEQHFIATAILLLLPIPLRAIETYLRRWRLAQAQGCQDAAS
KVPVKDPIVGFDFLYKVFFGKAPERYLDSTWQAFKEMGTTYIERRWSWQC
VYTCDPHNLKHILASACEDFDLPEFRTSVIGHVFGQGIFVLSGHTWKHAR
AVLRQSFRKGNPTPFLETLERNFQAFSKHVPTDGSAFDLQPLFLAFAMDV
STEFLMGHSTNMLSDKADHTREQQFVDDYMICSEEIIQQMQLGPLHRLKF
NFAANRAKKRVYEYLDIFIEES
LNSPRQGSKVSFLTDMMAIAGDRKGLSD
HILHILLASRDTTSSLLSNLFFFLSKNPRIYNKLRDQVLNVAGHEPPTAS
QLKELTYLKWCVNESLRLHPVIPTNARVAVRDTTIPRGGGADGTSPLFIS
KGTALFYNVYAMHRNKDVFGPEPEEFIPERWEDLRPGWGYLPFNGGARAC
IGQQYALLETHYVVARMAQTYTLLESRDDGDWMEFLDWFQWSIWTEDLMG
ANR*
>CYP584D2 Nectria haematococca
fgenesh1_pg.scaffold_1000851
Necha1/scaffold_1:2763714-2765329
79% to 584D1 Fusarium graminearum
This gene model seems correct
MLSPLLTKFLEQHLVLTIVLLLVPFPLRALETYLRRWRLAQARGCREARSKVAVKDPIIGFDFLYRALFS
HAPERYLDSTWAAFKEMGTTYVEKRWTWQCVYTCDPLNLKQILATASEDFDLPEFRTSVIGHVFGRGIFV
LSGHTWKHARTVLRRSFKKENPAPFLETLERNFQAFTSHVPTDGSEVDLQPLFLGLTMDVATEFLMGHST
GMLRNKGDHSREQQFVDDYMVCSEEIIQQMQLGPLHQLKFNFKAKKAKKRVYEYLDKFIDESLQHSKESN
PGSNFLADMMAIAKDRKGLSDQILHILLASRDTTSSLLSNLFFVLSKNPDIFAKLRQEVLHISGQEPPTA
HQLKEMTYMKWCVNE (1)
SLRLHPVIPTNARVAVRDTTIPRGGGADGQSPLLVPRGTAMFYNVYAMHRSEAVF
GPCAEEFIPERWRDLRPGWGYLPFNGGARACIG (1)
QQYALLETHYVVARMAQTYTRLESRDDRDWMELYALALCSKNGTRVAARR*
>CYP584D4 Fusarium oxysporum
80% to CYP584D2 Nectria haematococca
bad ag boundary in EXXR motif = gg
FOXG_03506
MFSLLLIKFLEQNLLATIVLLFLPVP
LRILETYLRRWRLAQAQGCKEATSKVAVKDPIIGFDFLYKVFFEKSPERYLDSTWQAFKE
MGTTYIEKRWSWQCVYTCDPRNIKQILATAYHDFDLPEFRTSVIGHIFGQGIFVLSGHPW
KHARALLRQSFRKDNPAPFLDTLERNFQSFLQHVPTDGSEVDLQPLFLALTMDVSTEFIM
GHSTNMLIQNADHTREQQFVDDYMVCSEEIIQQMQLGPLHSL
KFNFAAKRAKKRVYEYLDAFIQESLNKSE
DGPGSSFLAEMMDVVDDRTGLSHHILHILLASRDTTSGLLGNLFFFLAKKPEIYAKLRDEVLSVAGHEPPTASQLKDMTY
LKWCVNE (1?)
SLRLHPVIPTNARVAVRDTTIPRGGGIDGKSPLFVSKGTAMFYNVYAMHRNEDVFGPKAEKFAPERWKDLRPGWGYLPFN
GGARACIGQQYALLETHYVVARMAQAYSELQSRDDEEWMELYALALCSKNGCRVAAKR*
>CYP584D4 Fusarium verticillioides
93% to CYP584D4 Fusarium oxysporum = ortholog
FVEG_02372
MFSLLLFKFLEQHLLATIVLLFLPVPLGVLETYLRRWRLAQAQGCKEATRKVAV
KDPIVGFDFLYKIFFEKSPERYLDSTWQAFKEMGTTYIEKRWSWQC
VYTCDPQNFKHILATAYHDFDLPEFRTSVIGHIFGQGIFVLSGHPWKQARAVLRQ
SFRKDNHAPFLDTLERNFQSFLQHVPTDGSEVDLQPLFLALTMDI
STEFLMGHSTNMLIQNADHTREQQFVDDYMVCSEEIIQQMQLGPLHSLKFNFAAKK
ARKRVYEYLDAFIQESLNKSEDGSGSSFLTEMMDVANDRTALSH
HILHILLASRDTTSGLLGNLFFFLAKKPAIYAKLRGEVLSVAGQEPPTASQLKDMT
YLKWCVNESLRLHPVIPTNARVAVRDTTIPRGGGIDGESPLFVP
KGTAMFYNVYAMHRNEDVFGPKAEEFTPERWKDLRPGWGYLPFNGGARACIG
QQYALLETHYVVARMAQAYSEIESRDDEEWMELYALALCSKNGCRVATKR*
>CYP584E1 Aspergillus nidulans AN9384.1
MALLGLLETYRDPLAFVAALSAVFYLLSCLHRRWRRYQFAKENGCEPVVG
KIPSYDPFLSLDRLYRLTKLARNRKLLENNVQRFKEFGNTHRAKRITTPM
IVTRDPQNIKAILSLKFGDYSMGDRIRIFGPLLGHGIFTSDGEDWARSRH
MIRPNFVKEQVAHLEIFEELMDDLFALIPTDGSTVDLQELFFGFTIDSAT
EFLCGHNVHSLKKRRSGVIDDEPDFAEAFNYSLDNISKNGRFGPLMFLNR
DPKAVESHRICHESMDQFVDKAIRMRERYNEE
KIVDEAAERRYMFLYGLA
QQTGDRRRIRDEVLNILLAGRDTTASLLSNMFFLLAKHPSTWAKLQEEVA
TLEGRAPTYEQLRNMKYLKYCLNETLRLFPVVPVNSRTAIRDTVLPVGGG
PDGQSPAFVPKGTMVAYSVYAMHRREDYYGADAEEFRPERWADLRPGWEY
LPFNGGPRICVGQQYALTEAAYVTTRLAQRYSILESRDPGPWEEKLTLTL
CSYNGTQVSLRH*
>CYP584E2 Aspergillus fumigatus Af293
GenEMBL
XP_749919.1 also EAL87881.1
64% to 584E1
MTSNYSISLVAGAIAVFVYTLSVLRRKWTQYRFARAHNCQAPPRLASKDPLFGLDTIYATVQNVKEHKFL
ERAQARFDAVGHTIQTRRLLQTIIFTRDPQNIKTILSLRFKDYALGHRYKTFGPLLGHGIFTTDGEHWAQ
SRAMIRPNFVREQVADLAIFEAQMADLLELIPNDGRTVDLQDLFFSYTIDSATEFLFGQSVQSLKKRRSG
GRDAHAEDDFASAFNYAQHAIATRIRLGPLAAFYRDRKVERCNRVCHALVEQFVDKALEVRAQGGRVDEK
TLEDGDGEKKPRYVFLHGLAQQTGDRRRIRDEVMNVLLAGRDTTASLLSNLFFMLAKHPRIWARLRDEVA
PLNGRPPTYEQLRNLTYVKYCLNESLRLHPVVPGNARFAITDTVLPVGGGPDGQSPVFVPKGGIVTYSVW
SMHRREDIYGPDANEFRPERWADLRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQQFAVLESRDPG
PWEENLTLTLCSRNGTKVSLRN
>CYP584E2 Neosartorya fischeri
95% to CYP584E2 Aspergillus fumigatus =
ortholog
NFIA_022940
MTSNYSISLIAGAIAVLVYALSILRRKWTQYRFAREHNCQAPPRIPSKDPFFGLDTIYATIQNVKEHKFLERAQARFDAV
GHTIKARRLLQTIIFTRDPQNIKTILSLRFKDYALGHRYKTFGPLLGHGIFTTDGEHWAQSRAMIRPNFVREQVADLAIF
EAQMADLLELIPKDGSTVDLQDLFFSYTIDSATEFLFGQSVQSLKKRRSGGRDAHVENDFASAFNYAQHAIATRIRLGPL
AAFYRDRKVERCNRVCHALVEQFVDKALEVRAQGLDGKTLEDGDGEKKQRYVFLHGLAQQTGDRRRIRDEVMNVLLAGRD
TTASLLSNLFFMLAKHPRIWAKLRDEVASLNGRPPTYEQLRNLTYVKYCLNESLRLHPVVPGNARFAITDTVLPVGGGPD
GQSPVFVPKDAIVTYSVWSMHRREDIYGPDANEFRPERWADLRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQQFA
VLESRDPGPWEENLTLTLCSRNGTKVSLRN*
>CYP584E3 Aspergillus fumigatus Af293
GenEMBL
XP_747767.1
54% to 584E1
MHLILHPKTLILLLAVLVTIVCISIRRFLARRQFARQHGCQPV ARSLNKDPFLGLDTIPETLRAASQHRI
LERSVELFRLYGNTFTVKELHKYAILTIEPENIKTILSLNFKDYGLSHRLQPFKPLLGEG
IFDTDGAHWA
SSRALIRPSFTRGQVADLTALEDLMQDLFALLPRDGQTVVDLQELFFRYTIDSATEFLFGQSVGTLRKTP
SELGFAQAFHYAQKAIITRGMLGPLAVFYRDRKADECNRVCRAFVQRFVDDAFRAAENNGEKTPDGTKRQ
KRIFSHELAARTSDKRRVLDELMNVLVAGRDTTASLLGNLFFVLAKKPEIWEKLRAEVACLQGRTPTYDE
LRSLRYVQCCVNESLRLHPVVPRNERQAVRDTVLPLGGGSDGLSPVFVPKGTIVSYNVYVMHRRPGLYGP
DAEEFRPERWEDGKLQPRWGYLPFNGGPRICIGQRYALTEVSYVLVRMAQEFRVLESRDPGPWEESLALT
LCSRNGTRVCLVSG
>CYP584E3 Neosartorya fischeri
87% to CYP584E3 Aspergillus fumigatus = ortholog
NFIA_049440
MYPSLHPKLVLVLVAALATIACICIKRYLVRRQFARKHGCQPVARSFSKDPFLGLDTIPKTIGALRQHKILERSCNLFRN
YGNTFTVKELQKSAILTIEPENIKTVLSLKFNDYGLSHRLQPFKPLLGEGIFDTDGAHWASSRALIRPSFTRDQVADLTA
LEELIQDLFALLPRDEKTVVDLQELFFRYTIDSATEFLFGQSVGTLKKTHSELGVAQAFHYAQKAIITRGMLGPLAVFYR
DQKADECNRVCREFVQRFVDDAFHAVEGKREKKQDETGRQKRIFSHELAARTSDKRRVLDELMNVLLAGRDTTASLLGNL
FFMLAKKPVVWDKLRAEVACLQGRTPTYEELRSLRYVQCCVNESLRLHPVVPRNERQAVRDTVLPLGGGSDGLSPVFVPK
GTIVSYNLYAMHRRPDFYGPDAEEFRPERWEDGRLQPRWGYLPFNGGPRICIGQRYALTEVSYVLIRMVQEFRVLESRDP
GPWEESLALTLCSRNGTRVCLIPS*
>CYP584E4 Aspergillus oryzae
GenEMBL
BAE62566.1
SHORT part
of N-TERM MISSING
79% TO
584E2, 73% TO 584E1, 55% to 584G1
revised 3/20/2009
MIMNSSHYPVALLAGAVVFLVYTVTALQRKYIQYRIARANNCQPV
(deletion 87 aa))
IFTTDGDHWAQSRAMIRPNFVKDQVAHLDIFEELMADLLALIPTD
GTTVDLQDLFFCYTIDSATEFLFGHSVQSLKKRLSGVKLDDNDFASSFNYAQDAIAKNTRLGPLRHFFRD
TKAEHCNQVCHELVEQFVEKALKYRANYDEEKAATDDDKKQRYLFLQGLAQQTGDPKRIRDELMNVLLAG
RDTTASLLSNMFFMLAKNPHIWNKLREEVASLEGRAPTYEQLRNLTYLKYCMNESLRLHPVVPSNARFAI
NDTVLPVGGGPDGNAPVFVPKGSIVAYSVYSMHRREDFYGPDANEYRPERWADLRPSWEYLPFNGGPRIC
VGQQYALTEAGYVTVRLAQQFSVLESRDPGPWEENLTLTLCSRNGTKVALRH
>CYP584E4 Aspergillus flavus
99% to CYP584E4 Aspergillus oryzae
73% to CYP584E2 Neosartorya fischeri
AFL2G_08031
MIMNSSHYPVALLAGA
VVFLVYTVTALQRKYIQYRIARANNCQPVHCQVNKDPFLGLDSIHNNLDAAKKHVLLERSRSRF
REFGNTFRARRLRTPIIVTCEPQNIKTILSLKFKDYGLGNRIDAFGPLLGHG
IFTTDGDHWAQSRAMIRPNFVKDQVAHL
DIFEELMADLLALIPTDGTTVDLQDLFFCYTIDSATEFLFGHSVQSLKKRLSGVKLDDNDFASSFNYAQDAIAKNTRLGP
LRHFFRDTKAEHCNQVCHKLVEQFVEKALKYRANYDEEKAATDDDKKQRYLFLQGLAQQTGDPKRIRDELMNVLLAGRDT
TASLLSNMFFMLAKNPRIWNKLREEVASLEGRAPTYEQLRNLTYLKYCMNESLRLHPVVPSNARFAINDTVLPVGGGPAG
NAPVFVPKGSIVAYSVYSMHRREDFYGPDANEYRPERWADLRPSWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQQFSV
LESRDPGPWEENLTLTLCSRNGTKVALRH*
>CYP584E5 Aspergillus oryzae
GenEMBL
BAE65988.1
60% to
584E4, 51% TO 584E1
MELLPKLVILLLAALGIASVSIRRFLNRRQFARRCGCQPVARSFSKDPFLGLDTIPGTIRAIRQHRVLGR
SCEIFRAYGNTFTVKELHQSAIVTIEPENIQAVLSLNFKDYTLRHRLELFMPLLGRGIFNTDGQHWASSR
ALIRPSFAREQVANLSLLERLMQDLFVLLPRDSTTVDLQELFFRYTIDSATDLLFGQSVGALKKSQSGLA
FADALQYALKAIPVRDMLGPLNAVYRDRKTDECNRICRDFVQQYVEEAVYAAGPKKEEKESRTTETKRRY
ILSHELASRTSDKQRMVDELINVLLAGRDTTGSLLGNLFFMLAKNPVIWAKLRAEVAVLQNRPPTYEELR
GLRYVQCCVNES LRLHPVVPTNKRKAMRDTVLPRGGGNDGLSPVFVPAGTLVGYNIYAMHRRTDFYGPDA
KEFRPERWEDGKLQPRWGYLPFNGGPRICLGQRYALTEASYVLVRMAQEFRGLESRDPGSWEEGLVLTVC
PRNGTKVGLIP
>CYP584E5 Aspergillus flavus
99% to CYP584E5 Aspergillus oryzae
AFL2G_11341
MELLPKLVILLLAALGIASVSIRRFLNRRQFARRCGCQPVARSFSKDPFLGLDTIPGTIRAIRQHRVLGRSCEIFRAYGN
TFTVKELHQSAIVTIEHENIQAVLSLNFKDYTLRHRLELFMPLLGRGIFNTDGQHWASSRALIRPSFAREQVANLSLLER
LMQDLFVLLPRDSTTVDLQELFFRYTIDSATDLLFGQSVGALKKSQSGLAFADALQYALKAIPVRDMLGPLNAVYRDRKA
DECNRICRDFVQQYVEEAVYAAGPKKEEKESRTTETKRRYILSHKLASRTSDKQRMVDELINVLLAGRDTTGSLLGNLFF
MLAKNPVIWAKLRAEVAVLQNRPPTYEELRGLRYVQCCVNE (1)
SLRLHPVVPTNKRKAMRDTVLP
RGGGNDGLSPVFVPAGTLVGYNIYAMHRRTDFYGPDAKEFRPERWEDGKLQPRWGYLPFNGGPRICLGQRYALTEASYVL
VRMAQEFRGLESRDPGSWEEGLVLTLCPRNGTKVGLIP
>CYP584E6 Aspergillus niger
fgenesh1_pm.C_scaffold_19000013|Aspni1
67% to CYP584E2
MIALGAALCFFYVIKILRRKWIQSQIIRDTHCEPAALGSKDRLFGIDVLLQNFQAAKNHRLLELIQRRFQQYGNTFRVKR
FATPFIITCEPANLKAVLSVKFKDYGLGSRIETFGPLLGHGIFTSDGEHWAQSRAMVRPNFVKDQIADLEKLEELMLGLL
ELIPTDGSTVDLQDLFFCYTLDSATEFLFGHSVQSLNQLRSGVVSGENSFASAFNYAQHAIARNTRLGFLRRFVRDHKAM
RSNRICHNLVEQFIDKALKYREDYTKKTSGDEERRSRYLFLQGLAEHTGDRDRIRDELMNVLLAGRDTTASLLSNLFFML
ARKPNIWKKLREEVATLNGCAPTYQQLRNLTCLKHCLNESLRFHPVVPVNSRKALSNTVLPVGGGPGGKSPVFVPKGTIV
FYSVWAMHRRQDLYGPDANEFRPERWADLRPGWEYLPFNGGPRICIGQQYALTEAGYVTVRLAQQFSTLESRDSGPWEEA
LTLTLCSRNGTKVCLRN*
>CYP584E7 Aspergillus niger
estExt_fgenesh1_pm.C_10613|Aspni1
67% to CYP584E2
MAFDKVDHPVITIATVILVLWCTTTYLQRKWTHRRIIKANNCQPPPSYPQKDPIFGLDILFEQIKYSKKHKILERAIERF
KLYGNTFRQRRFTPFIITCEPENIKTVLSLRFKDYGLAGRIDAMGPLLGHGIFTTDGEHWAQSRAMVRPNFAKEQVAHLD
IFEELVNELISLIPTDGRTVDLQELFFELTIDSATEFLFGHSVHSLRKRRVGALDSTEQDFASAFNYAQKAIVADLRLGR
LKYLRRDRKVGECIRICHELVEQFVDSAMRVREQSSEQKAPPVGDSHDAKEKHKYLFLHGLAQQTGDRRRIRDELINILL
AGRDTTASLLSNLFFMLAKNPRIWNKLREEIAFLEGRAPSYEQLRNLTYVKYCLNESLRLHPVVPANLRFANTDTVLPRG
GGPDGKSPVFVPKGCTVAYNVYALHRREEIFGPDANEFRPERWAEIRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLA
QKFSVLESKDTGQWVEGYALTLCSRNGTKVALS*
>CYP584E8 Aspergillus niger
estExt_fgenesh1_pm.C_40266|Aspni1
76% to CYP584E5
MEFHPKLIILLLTALVIAGESFRRYLKRRQFARRHGCEPVARSFSKDPFLGLDTILGTMRTRREHRILERSCRLFRTLGN
TFTVKELGRSAILTIEPENIKTVLSLNFNDYSLKHRYEAMKPLLGEGIFNTDGHHWATSRALIRPSFAREQVTDLRLLEE
LIQDLFALLPRDGSTVDLQELFFRYTIDSATEFLFGQSVGALKESHSEVGFAEAFHYAQMAIPMRGMLGPLGVFFRDRKA
EECNRICRDFVQRFVDEALYAAATRKEDEATETKRKYIFSHELASRTSDKQRILDELMNVLLAGRDTTACLLGNMFFVLA
KNPAIWARLRAEVESLQSRPPTYEELRGLKYVQCCVNESLRLHPVVPRNEREAAKDTILPVGGGKDGLSPVFVPKGAVVG
YNVYAMHRRPDIYGPDAEVFRPERWEDGKLQPRWGYLPFNGGPRICIGQRYALTEVSYVLVRMVQEFRSLESRDPGPWVE
GLALTLCSRNGAKVGLIPSHTN*
>CYP584E9 Mgr002 Mycosphaerella graminicola
61% TO CYP584E3 Aspergillus fumigatus
MAPHTTLLLCTTLALLGYATWVHIRYRLDCRQFARAHGCKPTPKSYGTSIILGLDTLPDLIRAIRQHRLLDLGCEVFERYGHTFSATELGRHHIVTIDPDNIKTVLSLQFKDYAVGYRLDAFRPLLGESIFDTDGEAWARSRTLIRPSFARDQIADLASLESLFQDLLALLPRDGKTVVDLQPLFYRYTLDSACDFLFGRSACTLRGEHSGTDFESAFEYAKQAMLVRGTIGRLGMLYRDRKAEKAYRTCRDFAGQFVDEAIRKASGSGTTAEHDSSKRIFSHELAVRTTSRKVVLDECMSLLLAGRDTTASLLGNLFFMLAKNPAIWDKIREEVAFLDGRPPSYDELRQLRYVQRCVNESLRLHPVIPRNERQAVRHTVLPNGGGIDGSSPVFVAKGRVVAWNIHAMHSRKDIYGPDADEFRPERWENEELRPQWAYLPFNGGPRICIGQQYALTEAGYVLVRMAQEFSVLKSEDDGPWVESLAITVFPRNGVKVSLTPA
>CYP584E10 Aspergillus clavatus
75% to CYP584E2
ACLA_032820
MASHRFSLLLVAVLLAVYILSVLHRKWTQYRFARAHGCQPPVRLPLKDPFFGLDLMLQAIRNSREHKSLERTVRRFDTYG
NTIATRRFATRMIFTREPQNVKTVLSLRFRDYGLGRRINTFGPLLGHGIFTTDGDHWAQSRAMIRPNFVREQVADLHVFE
SLLVDFLALIPADAATVDLQDLFFSYTIDSATEFLFGHSVQSLKKRRAGGRDAGSEDDFAAAFNCAQQAIVNGNRLGPLR
FLFPDRRAEAARRVCHALVEQFVDKALAVRATPDEEKAQPPAAEKKRYVFLDGLAQQTGDRRRIRDELMNVLLAGRDTTA
SLLSNLFFMLAKHPRVWARLRAEIATLDGRPPTYEQLRALTYVKYCLNESLRIHPVVPGNARFANTDTVLPLGGGPDGQA
PVFVAKGTVVVYSPFAMHRREEFYGPDAEEFRPERWADLRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQRFSVLE
SRDPGPWEESLALTLSSRNGVKVSLRE*
>CYP584E11P Aspergillus clavatus
pseudogene ~70% to 584E3
ACLA_051510, ACLA_051500 (join)
MSILAAVVFIYRLARNCETSCLYGNTFTVQELQRRAIAVIEPENIKTVLSLNFKDYGIRYCLELFRPLLGEGIFNTDGDH
&
AASRALIRPTCA & DPADLRLLEGLLQDLMVLLLRDGTTADL*ELFFRYT
IYSATEFLFGQSVGSLKKKKEEDSSSLSELGFVEAFHYAQKAVLTRVMLGSFTAVY
RDHKADVCNRICRDFVQQFVEDAVQAAEGRRKEDDLLGEERMKTKEKRIFSYELASQTSDK
RRILDELMDVLLAERDTTASLLGNLFFMLAKNPAIWEKPRREVDVLQNRSPTYKELRRLKYVQCRVNEYIDLSP
ERWEDGELHLQLLPRWEYLPFNGGPRICIGQRYALNEVSYVLVRMVQKFRGLESRDPGPWEESLA*
>CYP584E12 Aspergillus terreus
77% to CYP584E6
ATEG_02893.1
MQTDQGHFSVAALGVAVVVVFYVLNVLQRKWKQARFIKENRCESVALSTESRLFGINQLRENVDAAKSHRFLTLTEQRFQ
RYGYTFRAKRFATSFVNTCEPLNIKTVLSLKFKDYSLGGRIDTFGPLLGHGIFTADGEHWAQSRAMVRPNFVKEQVADLE
KFEELMQGLLELIPTDGSTVDLQDLFFCYTIDSATEFLFGHSVQSLQKRLSGVSLDENDFASAFNYAQDAIAHKARLGFL
RRFVRDPKADHANRVCHELVEQFVDKALKYREHYDEEKAEGDEAKRARYLFLQGLAKQTGDRDRIRDELMNILLAGRDTT
ASLLSNMFFMLARNPEIWNKLREEVATLEGRAPTYEQLRNLTYLKYCLNESLRLHPVVPINSRRAIRDTVLPLGGGPDGK
SPVFVPQGTIVTYSVWAMHRREDLYGPDASEFRPERWADLRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQQFTTL
ESRDPGPWEEGLTLTLCSRNGTKVSLRR*
>CYP584E13 Aspergillus terreus
63% to CYP584E12
ATEG_01150.1
MVISALVSVGPTTFLKALFGFVALYFAILAIKQKLALRASAGHAVRTRGR
PFYVGLDMLWETLTHAKKHQFLDLQRTRFR
RYGNTFSTKRLATTVITTCEPSNIKTILSLRFKDYELKRLSSFGPLLGKGIFTTDGAEWMKSRAILRPNFDKPQLVNLEM
FESLMQEMFKLIPDNGDTVDLQKLFFCYTVDSATHFLFGHGVHSLRKLRLGSAGDDTEIQFATAFNYAQGSARIRHRLGP
LKALYHDRKAMECNKICHQLAEECIDKALQAQADGASGKKKRYIFLEELLAQTNDRRRIRDELLNILLAGRDTTASLLSN
LFFMLARHPHIWQKLRTEVANLDGQTPTYDQLRSFKYLKYCLNESLRVHPVIPVNARFATKDTVLPVGGGPDGQAPAFVP
RGSMIVYDVYNMHHRQDLYGPDADEFRPERWEHLRPRWEYLPFNGGPRICLGQQYALTEAGYVTVRLAQRYRTLESRDPY
PWVEDLTLALSSKNGTHVSLMT*
>CYP584F1 Nectria haematococca
fgenesh1_pg.scaffold_53000004
Necha1/scaffold_53:9312-10650
MQLTLTLLPVALAAAVAYFIAFQVTVYRRRRSHGCKPAPHAMAWDPIFGLKHATALHKAIRNHRNLEYFD
KMFKSYGNTFEVGLLGNLMHVTCDPENIKAILATKFADW (2)
(seq. gap about 184 amino acids)
(1) VLAAVGSEASLISTLFFVLARYPEVQEKLRQEMSNTLEGDRMPTYDDVRNMK
YLNWVIKEVLRVYPPVPQNLRVANKDTILPVGGGPDGRSPVFIPKGHECSFSSYSLHRREDLWGKDSLDF
RPERWEKERPTWSYIPFSGGPRICL (1)
GQQLALVGAGYVLLRFMQQYPTFKGPQPIQEWEEKLNITCFVNNGVWVNIG*
>CYP584G1 Aspergillus oryzae
GenEMBL
BAE59590.1
55% to
CYP584E4, 49% TO 52H1, 44% TO 584B1
47% TO 584E1
49% TO 584E2
MAVSLSFLTYLFLIVAGVYLARKISRAVQIRQFKKRHGCLPPPRDHHKDPVLGLDEVRSMLRVFREDYLM
EYTLEKYRRHGNTFATSVLGDDDIFTAEPENIKTILAVKFKQFDLGETRRRTFHPLLGDGIFAADGPQWE
HSRTLLRPSFTRTQIAATDLHERHIQRLISRIPRDGSTVDLQELFFNLTLDTATEFLFGESVESLRLGSS
AGSSSFAHHFN VAQDEIAFSMVIAPFDQLIFRPRFRESVREARGYVGN
FVKKAIEYRHSLDAEKHAGDTT
DSQSRYVFLEELAKETDNPSDITDQILNILLAGRDTTASLLSMVFYNLARRPDIWDLLRSEVATLDGKCP
SFEELKQLKYLSWVINETLRLYPVVPSNSRTANEDTFLPVGGGPDGKSPVFVAKGQRVAYDVYVMHRRHD
IFGPDAEEFRPERWETIRPGWGYLPFNGGPRICLGQQFALTEASYTTVRIVQSFKEITSRDPEPYRERLA
LTLASRHGTKVAMVPA
>CYP584G1 Aspergillus flavus
99% to CYP584G1 Aspergillus oryzae
AFL2G_07147 revised gene fusion
MAVSLSFLTYLSLIVAGVYLARKISRAVQ (1)
IRQFKKRHGCLPPPRDHHKDPVLGLDEVRSMLRVFREDYLMEYTLEKYRRHGNTFATSVLGDDDIFTAEPENIKTIL
AVKFKQFDLGETRRRTFHPLLGDGIFAADGPQWEHSRTLLRPSFTRTQIAATDLHERHIQRLISRIPRDGSTVDLQELFF
NLTLDTATEFLFGESVESLRLGSSAGSSSFAHHFNVAQDEIAFSMVIAPFDQLIFRPRFRESVRVARGYVGNFVKKAIEY
RHSLDAEKHAGDTTDSQSRYVFLEELAKETDNPSDITDQILNILLAGRDTTASLLSMVFYNLARRPDIWDLLRSEVATLG
GKCPSFEELKQLKYLSWVINETLRLYPVVPSNSRTANEDTFLPVGGGPDGKSPVFVAKGQRVAYDVYVMHRRHDIFGPDA
EEFRPERWETIRPGWGYLPFNGGPRICLGQQFALTEASYTTVRIVQSFKEITSRDPEPYRERLALTLASRHGTKVAMVPV*
>CYP584G2 Neosartorya fischeri
56% to CYP584G1
NFIA_063580
Note: this seq has no ortholog in A. fumigatus
MVQNSHQTGKRRKQSRTDDEIERKYAHKHGCRPPKHSVSLGPFGLGMIMTMLAATREHRFLEQVRSWHRAYGTTFKATMI
VRKAIFTVEPKNVQTVLALKFKDFELGEYRNRAVRPLLGYGIFSTDGSVWEHSRALLRPNFTRNQIADISVYETHVAHLI
KQIPRDGSTVDLQDLFFRMTLDSATEFLFGESVHSLGDAASAPASSFAADFNASQRGLALRSRLGSLMMFYRDKQFSNAV
ADARSYVDRFVQKAIDYRIALDNGQYVSEEARKVNEQQYVFLHELSKRTLNKTELTDQLLNILLAGRDTTASLLSITFFT
MARRPDIWNKLRQEVLALGGRKPSFEDLKSMTYLTWVLNETLRLYPVVPINVRMANKDTVLPVGGGHRGKDPVFVPKGYE
VIYSVYTMHRLPEIFGDDADEYRPERWEKLKPGWAYIPFNGGPRICLGQQFALTEAGYTTVRLMQQFEAIESRDPKPLTE
GLTLTLASLNGTKVAMKPAKGS*
>CYP584H1 Aspergillus niger
e_gw1.19.73.1|Aspni1
44% to CYP584E2
MALHGLHALAVIALLWPLLLQAIYRAFRASSCQRFRLLHGCQSAPKGGRRSLPFGIDNLAVLWRATRENRVLETVESDFR
SSGHTTMVQRHLNRRMVITCEPENIRTILSLKSEDYSVESRNQAFGPLVNTGILISDGVTWAHSRGILRRNFTRSHLANF
EPLEQTLQDLISLLPRDGVTVDLQPLFLRYTLDIASGLHLGQSLHSLRQKAASNGKPTRIDEFKEAMGHAAKDVARRHHL
GVLRYFFIDLRARKSYRTYQAFVDQLVEEALRDSKKSSLASESSCASSGPYVALHEWLEQTTDRRRLRDEVILMLLTSGD
TTASLLGNLFSMLARHPTVWQKLRAEISSTLQGRRPTYEELPRLQYLRYCINETLRLIPSIPLVDRVARRDTVLPVGGGP
DGKSPLMVPQGSQMVCCMYSLHRRVNHFGSDAEEFRPDRWATRQPGDEFMPFSTGPRACPGRQFALTVTEYVTVRLVQLF
PRLEGRDAQPWQGDLSAMLLPKNGVKVALWS
>CYP584J1 Mgr036 Mycosphaerella graminicola
51% to CYP584E2 Aspergillus fumigatus (yellow region is
long)
41% to Mgr002 548E9
MADLTKLSATAQLATGIACLYIFYLLTTTTSIWLRRRSYKRSKGVMPAVRIPAKDPIMGMDLFLRNIRALKDHTLLELGMARFANLKANTIRGLGLGREIHGTIEPENLKTIQAVDFKKWGLGTGRKTGFHPLLGQGIFTSDGPDWQHSRDMLRPNFVRSQIGDTETFEKHISHLIAAIPKDGTTVNLSDLFFRLTIDSATEFLFGESTESLTKDSTDGFAEAFNNGQDFIANKARWGKWARFAPKNKRFEADRKFVHDFVDYYVDKGLAKRAQLLTEDKKPQRYVFIDELVRQTTDRVRIRSELLNILLAGRDTTASLLTNVWFILSKRPDIWAKLQSEVGQLNGVRPTFEQLKDLKYLQSILSESLRLHPVVPLNSREAQCDTTLPVGGGPSGLAPIFIPKGGIVSWNVYAMHRRKDIYGPDAEDFTPERWLD
DPETGKKG
LRPGWGYLPFNGGPRVCLGQQFALTEASYATVRLCQAFSGIESRDPEEWKEFLMLTCVSLNGAKVKLTPREG
>CYP584J2 Mycosphaerella fijiensis
67% to CYP584J1 Mycosphaerella
graminicola
estExt_fgenesh1_pg.C_90431
MEVSHMSHTTRAALGLATLYIAYQVITSITLWARRRAFKREKGVMEAPWYPQWDKITGLNLFRKNVQALKEHRMLEVGHR
RFSETSSNTYQLVLLGQHMHITTEPENLKIIQAKEHTKWSLGRRRKYGFRPLLGEGIFTTDGSAWQHSRDMLRPNFVRSQ
VADVDTFEKHVSQLISIIPRNQTVDLSELFFRLTIDSATEFLFGESTNSLASNTTDGFADAFTHGQDFIANLARWGSIGK
LFLATKRFEKDTKFVHDFVDYYVQKGLARRDQILAEKTIGDGKSGRYVFIDELVKQTTDPIRIRSEALNILLAGRDTTAS
LLTNVWYTLSNRPDIWEKLQAEVKQLDDARPSFEQLKDLKYVKALLNESLRLHPVVPLNSREATEDTTLPLGGGPDGRAP
IFIKKDSVMAWSVWAMHRRKDFYGEDAEEFKPERWLDDPVTGKKGLRPGWEYLPFNGGARICLGQQFALTEASYCTVRLC
QAFSGIESRGPNPWTEFITLTCVNLHGAKVALTPRET*
>CYP584K1 Uncinocarpus reesii
47% to CYP584G1, middle region similar to EST
from Coccidioides posadasii GH403863.1
UREG_00396.1
MLNTTNTALILVAAGALHFGYRYVRSYLEIERIRKMENAEEPPSDPDEGLLGIAIYRRMAKDQGEHVFLEEQTKLYERLG
DTYKANLFGRPFIDTRDPENIKAILSTQFEQFSLGESRLDAFHPMLGDGIFTHVYGGGPKGEPWRHSRAMLRPQFAKQQI
QDLENLEGFVQTLISRIPGNETCDLQELFFRLSMDTATDFLFGESVNSLLPDSPPRETRFYHCFSRGT
(1)
EICMLRSLLGDLYFLQKDGREFKQISAFVKEYIDRFTYKALQLH
ADGKPTSYDANGKYIFLEEISKSIKDPVRLRSELLNILLAGRDTTASLLAICFHQLARHKDVWNQLRNEIMENIGHRHPT
YEDIKSLKYLKYVLNETLRLFPVVPWNGREAVVTTTLPRGGGPDGKSKIVVKKGTFVFYSPWSLHRSKFYGEDANEFKPS
RWETLRPAWNYIPFNGGPRICLGQQYALTEASYVVIRLLQAFKDIDNRDPIEPFIEHTTLTLSSHTGTKVALTPA
>CYP584K2 Coccidioides immitis
80% to CYP584K1
CIMG_00331.2
MLNLTNVLLIPPAAGALHVGYRYLQSYLEAERVRKLENTEDPPKAPNQGIFGINVYRDMARHKEEHVFLQKNLERYDELG
DTYTSDMFGRTYIDTRDPENIKAILSTQFEQFSLGDSRLDAFYPMLGEGIFTHVYGGGPKGEPWRHSRAVLRPQFARHQI
QDLAKLEEFVQNLISRIPRNETCDLQELFFRLTLDT (1)
ATDFLFGESVNS
LLPDSPPKETQFYHDFTRGTEICMLRTLLGDLYFLQKDSSEFKRVSAFVQEYIDRFTHKALELHAAGKPTSY
DSNGKYVFLEEISKSIRDPVRLRSELLNILLAGRDTTASLLSACFHQLARHKDVWDELRKEIMDNVGDRLPTYEDIKSLR
YLRYVLNETLRLFPVVPWNGRQAVVTTTLPRGGGPDGKNKILVKKGTFVLYSTWGLHRSKFYGEDTNEFRPSRWETIRPG
WNYIPFNGGPRICLGQQYALVEASYVITRLLQVFKDIENRDPVLPFVEHTTLTLSSEHGAKVALTPA
>CYP584L1 Uncinocarpus reesii
49% to CYP584G1, 45% to CYP584K1
UREG_01634.1
MLSALKDAPPGHLALGAVACFILYQVYIYLTVGASRRKFAADHGCQPAPAYPHREPIFGIDLA
LKLARYGKSKTFLEQAR
NRFLAYGNTYSLKVMG KNAITTCEPENIKATLATKFQDFNLSNVRKAAFQPLFGKGVFTNDGPEWEHSRTMLRPNFVRSQ
VADLDMIEKHVQNLIKEVPTDGSTIDLQDLFFDLTLDTATEFLFGESAHSLGSKSTEENERFSDLFTYCTTMIGDWSRIG
IFFGIPDQRYHRFAAGIHKFADRYVEKALAHHRAQKSGMITCENSPNRYIFLDELVKKTNDPIELRSEALNILLAGRDTT
ASLLACLWNVLSKRPDVWSKLRAEVDSLGGKKPSFEELKDMKYLRYCINEALRLYPVVPSNGRVAIRDTFLPVGGGKDRK
SPIFLKKGTLVSYSVFSMHRREDIYGPDAAEYKPERWEKLRPGWEFLPFNGGPRICLGQQLALTEASYTTVRLMQHFRDV
ESRDSHPWTELLTVTCASNYGAKVALKP
>CYP584L2 Coccidioides immitis
76% to CYP584L1, shortened the N-term
CIMG_04399.2
MLSALKDIPPGHLALGAAACFLLYQVYLYLTLGLARRKFIQQNGCRP
PPAYPHKDPILGLDWALKGMKYSRSRTFLQGTQKRFREHGNTHSLNVIGKPAIATCDPENIKATLATKFQDFDLSTVRKR
LFQPLFGKGIFTTDGAEWEHSRAMLRPNFVRSQVADLDMIERHLKNLFKEIPTDGSTVDLQDLFFDLTLDTATEFLFGES
AYTLTKKDMGSGERFSDIFTYCTAVIGQWARLGIFLGIPDRRYHRYAAGVHEFADRYVQKALENYRAQQSGMITSDKTSN
RYIFLDELVKSTQDPVELRSEALNILLAGRDTTASLLACLWNVLSKRPDVWSKLLNEVDALNKKRPSFEELKNMKFLRYC
VNEALRLYPVVPGNTRVAVRDTFVPVGGGPDGKSPVFVPKGTLLNYSVYTMHRREDIYGPDAAEFKPERWEKLRPGWEYL
PFNGGPRICLGQQLALTEASYTTVRLMQEFRHVESRDPNPWEELLTVTCASAHGAKVALRP
>CYP584L3 Histoplasma capsulatum G217B
ABBT01000202.1 Ajellomyces capsulatus G217B
64% to CYP584L1
HCB05383.1
586513
MLSLIHVVVGAFGCFFLYQVYLYFTVGAARRKLVKEHACRPPPAYPHKDPIFGLDLTMKLRGHKQ 586319
586318
KNILLQESVKRYRIFGNTFSLI (1)
586149
AISTCEPENIKCVLSLKFSDYEINALRKTAFHGVFGQGIFTTDGPQWEHSRTMLRPNFNRAQVAELAIFEAHIQ
NLIQVVPTDGSTVDLQPLFFDLTADTATEFLFGESANTLHKNFKPSTEENFAEAFTYCTTEIGNSLRVGLLDRYFKTDKR
FERDRKLIHDFADRYVKKALENHANEKYGSGPLPEKGRYVFLQELAKQTQDPIALRSETLNILLAGRDTTASLLANVWNI
IPKRPDVLKKLRAEVDQLGGRKPTFEELKNMKYLKYVLNECLRLWPVVPNNARAAIRDTILPLGGGPDGKSPVFVKKGTT
LAYSVYAMHRRQDIYGPDAAEFRPERWETIRPGWEYLPFNGGPRICLGQQFALTEASYTTVRLMQHFRTIESRDPEPWTE
WVTITCASHHGAKVSLKP* 584657
>CYP584M1 Aspergillus clavatus
44% to CYP584E2
ACLA_055810
MWQYLLGSILLLVALHLVKRVEQWRNRRRYAQKYSTKDPVRISDIRRPEGGSYTKETVQAFRKHQGLELLRKRHEACGYT
FESHTLGGRIVNTSEPENIKAVLATHFQDYSLGFRQAALGPLLGKGVFTTDGQEWKHSRGLVRPNVEKAHVTDLSILEKH
IRQLLAHIPRDGRTIDVQDYFFKLSFDNSTEFLFGESVRSFEAAENSEEARFAAAFDFASGETIRRLQYGPFLPLYFNRD
FTKACKVVHRFVDNVVAKALARRASRKAGEKTGNYNFLDGLMDSVTEPKRLRSETLNLMQAGRDTTAGMLGHVFYLLARR
SDVWAKLEAEVATLEGRAPTYEDLQQLTYLRQVMNETLRIYPVAPINSRVAVRDTILPTGGGPDHKSPIFIPAGQKISFP
VYVMHRRKDIYGPDANEFRPERWGEPNFRPGWAYLPFNGGPRVCLGQQFAMTEVGYTIVRLVQTFKAVIQRDFSPYKEHV
RISASVYGGVQVGLIPRD*
>CYP584N1 Mycosphaerella fijiensis
44% to CYP584E12 Aspergillus
terreus
44% to CYP584E10 Aspergillus
clavatus
gw1.8.206.1 revised at N-term
MLPLLLSGLLVAFVLNIICKRASLASRRKFFEQKHACQPPKHYL
ATPWWDQYGLNLMRSMLAAAKKSQILEYVHLLTQIHDPEKRGFGNFVAVSRFGTRKTVIS
SDPENVKSVLTRADDFLVEPSRLAAFEGLLGKG
IFTSDGAFWQHSRAMLKPQFDKSQITELDQFERHISKLLALIPDDGSTIDLQPLFHRLTMDTSTEFLTGTSANSLDADEE
ASQEARDFVTAFDLAMEAGTLHARLGKLYNLFPHPAARRANATSRAYIQKWVDRALKNQAERAEKAKKGEQYVFIDELVK
HDEVDRTRALNETMNILLAGRDTTATLLTHLFFNLAREPEVWSKLLAEIDELNGELPSYEKLRDMKYLRYCTQETLRLHP
PVPMLSKAASRDTTIPHGGGPDGLQPLFLAQGDNFFYSTYALQRSEAIYGKDANIFRPERWSDANLRPFWAYIPFGGGQR
VCLGQQYALAETYYVTVRMMQTFRKIEDRDGGVWVEKVAATLGSGNGCLVGL*
>CYP585A1 Magnaporthe grisea MG10071.4 38% to 52F5 AACU01001328 cont2.1928
MSNFSFQLNSIALLITLTALLLIYKLLNSFVIRPLHNHLAARRLNCGSLP
TEPSKWPFGIDTVLRGLQADRDQQMPDYVASRFAAMGRYTWRISVLGTSN
IITAEPRNVQALLATQFDDFSMGDARTTNLRILLGRSIFAVDGAAWHGAR
ETMRPLFARDNVSNVELLEGNFQKLLRCIKQELHKDAEGRLWTAPTSLAA
LLPSFTLDSASEAFLGSSAGALDARLDGSAQPHLLWALERMAPLLRVRFA
LRGLYFLYGTRELRRCADAMHAFVDAAMTRADDALKQDHDGQHLGGKRFE
FLQKLRARCADRAEVREQVLGLLAAGTDTTAALVGWVFYSLIRHPRVFAR
LREAVLEDFGATGRQVTFERLKSCRYLQQVLSETLRRHSVVPLNSRRARR
DTTLPTGGGADGTQRVFVPAGTEVNFSTHVLHRRGDLWGRDADDFRPERW
AERRPGVFHYVPFNGGPRICIGQQFALTEAGFVVVRMLQEFDAVEGLHVD
PERDWHNFGITCSPGSPEDRHAGVTCRLRLAS*
>CYP585A2 Alternaria solani
Alt2 BAD83681 65% to 585A1 Mg
PKS for alternapyrone is next to three P450s
called alt1, 2, 3
Chem Biol. 2005 Dec;12(12):1301-9.
1 mqthllilaa vvlliihivn nflikplqtl lksrrlgcgp
vpfeptrwpl didtirrslk
61 adkeqrtpdf vagrfetmgr
ytwglsllgt snlitaeprn vqallatqfd dfimgtarrt
121 nlktalgrsi favdgkawhr aretmrpifs
renvsrlell eehvqtmlqi ietkdegltt
181 dandrawsap vslavllprl tmdsatelfl
gqsthslkka larqqqksgn eehdadsfdh
241 afermlailg trmrlrslyw lygnkelqkc
inalhafvds aidaadqark sgssqlrydf
301 letlrtrcsd raevreqvlg llaagrdtta
sltawvfycl vrnprvykkl rdtvlaefgp
361 ystnpgqkit feklkgctyl qhvlnetlrl
hsvvpfnsrc aardttlpvg ggpdgsmpvf
421 vpkgtevnfs thvlhrrkdl wgedadefvp
erwekkrpgm twqyvpfngg pricigqqfa
481 lteagyvlvr mvqrydvieg ldidverdwh
nftvvcspgs pvardaavmc rlrvave
>CYP585A3P Fusarium oxysporum
59% to CYP585A1, stop codon, frameshift =
&, no start Met
FOXG_10811
LSIHLLNLLCKDVSHAHRAGQRGCLPAPLEPSKLPFGIDTLLASLRAD
RDQRTPDHVANRFAALGVYTFR
MSILGTTNLVTAEPRNIQAILATQFNDFGMGATRSTNLKTVLGRSIFAAD
GASWRAARDMMRPLFSRDNVSRLDVLEEHVQTLFRCIE
KEKSPTIAGGT*
SAPVSLAALLLSLTLDSATELFLRQSTSTLQASLDGDDSHLG
MVFHHAFERMVAVLETRV
RLRSFYWLYGTRELRLCVETLHGFVDIAITAS
DMAKKEGSSQALYDFLNVLRERCSGGDEEV
REQVLGLLAAGRDTTASLMSWTWYCLLHNPRVFAKLRSEILSTFGCSPDGPSVTMTFASLKECTYLQHVLSETLRL
&
TVVPFNSRRALRDTTLPMGGGPDGKSPIFNPKGTEVNFSTHVLYRR
KDLWGEEDADDFVPERWEKQRGAASAAWHFVPFNGGPR
ICIGQKLALTEAGYVLVRMLQRYDAVKRLDVDLTRDWHNFTVVCSPGSPVNRNQAVLCQLKLA*
>CYP585B1 Magnaporthe grisea MG08947.4 42% to 52F5 AACU01001732 cont2.1680
MAHSTVSLALAAVGIFTLYLISKVILKTWQNATEARRLGCKPPASFPSWC
PFGLDIVRKLIISRRQMRTPEWLREQLAKTSTPANPNNLTCSFQIVHTSG
ILTADEVNVHAMLSKQFDDFEVGQTRREIARPLVGESIFTTDGHAWKMLR
GLVRPSFARHQVGDLELDEKHFKNMMACLETGSDGWTGNIDLQTLMFRYS
LDSSTEFLCGASVGSQLKELQLQNGKVTDDEDEIDFASALDRAMEGLATR
GQFFKCGPYIWPRGFEKACRDCHAFIDKYVARRQNKTLAAAEKQPPAESP
PAAKEKYIFLDALAESFPDPVELRHQILGVLFAGRDTTASLISWVFYNLA
RDPARCHKLRRAVLEHFGGPREEEEEDPGRAVTFESLKECRYLQHVINET
ARLCPVVPVNSRRARRNTTLPRGGGPDGQSKVFVKEGTLVYFAPYIMGRR
KELWGEDAERFVPERWEGKRHGWEFIPFSGGPRICPGQQSALTKTAYVIV
RLLQRFDRIESWDPEVDVKHDATATMCSGTGVKVRLHADGF*
>CYP586A1 MG09179.4 poor match AACU01000638 cont2.1755
MLNSIPNVYALGLAAIFLAAVYIYRDVRWRRFSQHADLAQLKPSLFWGHM
KALGERLREKPAGTHHDYVFAEIQQELGNPPMFNFDMRPLARPMVVIANH
ELAEQASRASKTFPWSTHKSPSLHEISPLTGENSLLAKEGEEWKALRRRF
NPGFAPKHLLSLLPCILDKTQYFIDHLDRLARSGDEFLFNELTTNLTFDI
IGAVVLDVDLDAQRGKSELVNAFQAMTKTFLDPSPPGFARFFLRQRFIRW
RLRQRMETVLRRYIIDCHEKQNQAQGSIGQSRSVLSLSLEGLETLDESLI
SMISDQMKTFLFAGHDTTSIALQWAMYELARTPRALAAIRAELDEIFGPD
TNPATVRDQLLGPSREELYARLQYTSAVMKETLRLHPPAGSGRFAPKGSN
FRFTMPDGQGMSPVMDNKILYLCHYLIQRDPAVYGETASVFEPERWLGNT
DTSMAGGGDLNDAAPGLAGEKHAIPASAWRPFERGQRNCIGQELANIEMR
VILACTVRRFDFEKVGLGELLRDEKGNFVMDTYGQYKTVNLLYNASKITA
QPTDGCRMRVRLSDKAQAASRT*
>CYP586B1 Nectria haematococca
e_gw1.24.71.1
Necha1/scaffold_24:469714-471122
47% to XM_743428.1 Aspergillus fumigatus 46% to 586A1
16 amino acids not found that would match
586A1, no intron boundary here
MVLKPFIFAAVSLLITYLIAKLRFKRFKQYAHLPQLPPSLIWGHML
(0)
XXXXXXXXXXXXXXXX
DLIFAEMYEKLGRPPLIFVD
MRPVSNPVALITSHDVAEQVAKSSALFPWSTPKTPTMKDIIHLLGPSSLISAE
(0)
GEDWRKLRKRFAPGFAP
NQLMTLLPCILDKTEPFINRLEDHARSGEQFSLLTLIVNLTIDVISAVAMDEDLEAQTIDPSGQSQVIRL
FMELLSTYSSRHNLPWWLAPSLGAKRRRLAGQVDGMLRDIVQRKFEEHQKTSGGNKPRNILSLSFQDIDE
LTPELLSHTSDQMKSFFFAGHDTASILLSWTFYELSRSPRVQKAVRAELDELFGPDPDPSVVRSNLYANG
EDLVRRMTYVSAVIKEVLRIHPPAGTGRYAEPGSGFTVRTSTGEELCLDGTIIYNCQHIIHRDPTVYGTS
ANDFVPERWLGETSAWGFIPSAWRPFERGPRNCIGQELANIEARVIIAIVARHFDFVKVGLGELELDENG
RPILNDKDQYKVKSELYPVSQARRTVRGSSSS*
>CYP586C1 Aspergillus fumigatus
XM_743428.1 end may be wrong
AAHF01000010 revised
MFLILSVIATLQLLAFWLLNKLDYYRIKQFAAWPQPKPSRIWGHMKDLNAFISRGEPNRHIGK
(2)
EDYVFAEIKAHLGNPPLYLLDARP
MQHPLGIVCSHEIAEQVSRSSKQFPYGLPKTPTLQDYKYLVGPHSILTSE
GEEWKSLRKRFNPGFAPQHILTLLPRILDKTVPFFETLDRYAESGEEFSLAETCTNLTFDII (1?)
GAVTMDEDLGAQL
PLDKQSEMVRLYHELTASYHQKSSVRAKPSNPLVIWQQYKLARKLNAIIKNHIKRKFA
ELKEASSDEKKSRSVLALSLQGIEKLDAHVLDQTCDQLKTFLFAGHDTTSIVLQWAFY
ELSRTPRVLESISRELDDVFGPDPSPAVVRDKLLAPNGGELLSKLPYTTAVIKEILRV
YPSSGTGRLVPEGSDVYIQLPDGRSLCIDGVLMYNCETLIHRDETVYGESKDDFLPER
WLGDSGADRIPSSAWRPFERGPRSCIGQGLATIEAQVILACAVRQYEFVKIGLGEVAR
DNAGEPILGPQGQYEVKSKLFNV (1)
MTAKPVDGMIMKVKLSSGGRKEL*
>CYP586C1 Neosartorya
fischeri NRRL 181
DS027697
join(701574..701711,701768..701954,702008..702981,
703037..703117)
92% to
586C1 = ORTHOLOG 51% to 586B1, 48% to 586A1
NAME
REVISED FROM CYP586C2
NFIA_003100
MFLILSVIAALPLLAFWLLNKLDYYRTKQFAAWPQPKPSRVWGHMKDLNTFISRGEPKRHIGK
(2)
EDHVFAEIKAHLGNPPLYLLDARPIQHP
MGIVCSHEVAEQVARSSKQFPYGMPKTPTLQAYKYLLGPHSILTSE
GEEWKSLRKRFNPGFAPQHLLTLLPCILDKTVPFFETLDRYAQSGEefslaetctn
LtfDII
GAVTMDEDLGAQLPLDKQSEMVRLYHELAASYYRKSSVRAKALNPLLIWQQY
TLARTLNAIIKNHIKRKFAELKEASTDEKKSRSVLALSLQGIEHLDAHVLDQTCDQLK
TFLFAGHDTTSILLQWAFYELSRTPRVLESIRRELDDVFGPDPSPAVVRDKLLAPNGG
ELLSKLQYTTAVIKEILRVYPSSGTGRLVPEGSDAYIQLPDGRSLCIDGILMYNCETL
IHRDETVYGESKDDFFPERWLGDAGADRIPSSAWRPFERGPRSCIGQGLVTIEAQVIL
ACAVRRYEFVKIGLGEVARDSAGEPILDPQGQYEVKSKLFNTMQVTAKPVDGMIMKVK
LSSGGRKEL
>CYP586C3 Aspergillus niger
e_gw1.3.1357.1|Aspni1
63% to CYP586C2
MFAQTILLILLPLVVSYFITRIRYSRFKKYADWPQLPTSLVWGHMKALHEFIVRGEEKRHIDIVFGEIQEHLGNPPLMFF
DLRPVQFRLCVVGSHEIAEQVSRSTKSFPYSMQKSPTMGALEPLLGPYSIITQEGEHWKGLRKRFNPGFAPQHLITLLPC
ILDKAIQFTDILDAYARSGEELSLDERCVSLTFDIIGAVTMDKDFHAQLDRSKQDELVRLYRELTTSYRSGSGIQWGWLD
VRVLWRRRVLTRRIDHLISEHIKTKFDELKSKSTEKRSRSVLSLSLQDIDQLNTRVIQETCHQLKSFLFAGHDTTSIVLQ
WSFYVLSRTPRVLDKLRRELDDLFGPDPSPAAVQEKLLAPGGDDLLKRMSYTSAVIKEILRLYPPSGSARYMPPGTGFTV
QLPDGKTLCLDGVVVYNNSTLVHRDEKVYGPTKDEFIPERWLGDADTGLGLSTDNVEDKGNGPVATACIPASAWRPFERG
PRNCIGQELANLEARVILACTVRRFDFEKVGVGAIARDATGAPILDAKGQYEVESELFNTMQVTAKPIDGTVVKVHLAER
AS*
>CYP586C4 Neosartorya fischeri
56% TO CYP586C2 Neosartorya fischeri
NFIA_106770 revised
Note: this seq does not have an ortholog in A.
fumigatus
MCVVCSHEVAEQISRQSRMFPYSVPKSPTTKAFVDLIGPKSIITAE
(0)
GCEWRDLRARLNPGFSAGNLMTLLPCMVEKTLLFVDILDQYAASGEHFMLNELCTNLTFDII
(1)
GAVTMGVNLCAQLGEDRQSEIVKIFKEIGSTYSSQRGIWTAPLVRLRRRKLVSKLNALLTGFISETFEEVKRTPQTKESTRLGS
RSILTLMLQDANELTPAIMDRTCDQLKSFLFAGHDTTSILLQWALYELSRTPRAMDAVRRELDSIFGPDTSPRSVSNILL
SEDGTALLSKLRYTSAVIKETLRLYPPSGSARYAERGSRLTLRLPTGRVYCVDGLVLYNCATIIQRDETVYGESKDEFVP
ERWLQDNELNMHLSQYRDHDCYREARFAGPASAWRPFERGPRNCIGQELAMIEARLILASVVRRYDFSKVGLGEIAIDEN
GQPALNSHGQYETKSKLYNVITSLPPRPAFAFCWLTSSVKDVTGDSKTHRWDENEREAKRNSV
>CYP586C5 Aspergillus terreus
62% to CYP586C3 Aspergillus niger
ATEG_07654.1
MFLRMVLLAVLPLLGFYLYEKARHSRFQQFAAWPQLKPSLVWGHLKAFNKFIATADPSRHIDIVLQEIRRHLGNPPLFLL
DLRPIQRPLVIVCSHEVAEQVSKSTKELPYSVPKSPTIKALEPLLGPNSILSAHGEQWRSLRKRFNPGFAPQHLMSLMPC
ILDKAWRFLENLDRHALDRNEFSLDEPCVNLTFDIIGAVTMDEDFCAQLGQDKQTELVRRFRELTLNFRTVTSNQWFTLN
PRTIIHRWWLSRRIDTILSDHIRAKFAELKAQSAAGAKSRSVLSLSLQNLDRLDNRIVAQTRDQLKSFLFAGHDTTSILL
QWAFYELSRTPRALAATRAELDDIFGADSSPAVVRDMLLSSQREGLVRRMSYTSAVIKETLRLYPPSGSARHLPYGSGFT
VALPGGGSLCLDGTVIYNCSTVIQRDEGVYGPTAAEFRPERWLGDTDTSMQTNVDAKEDAGRIPASAWRPFERGPRNCIG
QELANLEARVILACTVRRYDFEKVGLGAITHDSTGLPVVASNGQYEVENEVFNTMQVTAKPVDGMKVKVRLVPGAAPLLA
>CYP586C6P Aspergillus clavatus
~50% to CYP586C3
EDWKRLRQPFNSGFAPQHLMSLLLCVL
IGLLAMDDDFHA*CEASQQSEIYKALYTS
IK*KFLELQDGSTEKKKSRSILSGSVQDIESLDDQLIEKISASLKSFYFIGYQKTSTVL*
WVFYSLSCTPHALRAVQKILDGIFGLHRQYAVKTELFNISHHE
>CYP586D1 Aspergillus niger
estExt_Genewise1.C_70085|Aspni1
44% to 586B1
MLLLLLLTTIFLTSVWICRWIWYERFIKFAQFPQLPPSLLWGHLRIYHEVMQSGSLDRDHDHIFSQIHESLGRPPIVLFD
YRPICRPVLVIANHEVGEQISRSSKQFRSSVPKLGLSFLEPVIGHTSILSAEGEKWKALRKTFNPWFSLQHLMSLMPSIL
GKIEIFVTQLDALSVSGDEVSLVTLTTNLMYDIIGNAIFDIDMDAQHLEPGHQGELVRAFNDLINAYWDDKIHLPWFFTP
VNALKRRRLGNRVHRIMKSIVRRKHEEHLWRQQQQRRTNGYEKRPQPQLPPSITLLSLQETTHTGGILTPELLDQTCDQL
RTFLLGGHDSPSATLAWAFYELSRTPRAQAAVHAELDGLFGPGRDAAAVRTALASPTEGPDLLRRMVYVEAVLKETLRLH
PPASTARYSPKGSGFVVRLPTTGEELCLDDLILYNCSAIMHHDRGVFGSTANQFMPERWLMAEDEKNTNQRTIPPSAWRP
YERGPRACIGQEFARITMRVVLAVVARQYEFIKVGIGALARDASTGLPILRPDGRYEVDSQVYTTRQITARPVDGLKVKVK
>CYP586E1 Histoplasma capsulatum G217B
ABBT01000222.1 Ajellomyces capsulatus G217B
45% to 586C3
HCB06858.1
MSVSPFQTASPLLIICAASVPLLVFFLYSRLKYYRFHQFSHFPQAPPDLFFGHLKIVNETIAEEPGRHHGMIHL
(0)
VSKASAMFKYSVPKSPTAGMLIPIVGKKSIILTNDETWKHGRKKFNAAFASSNLVTFMPKILDKTMEFLALLDGYVESGEEFCLAE
PCIQVTFDIIGLAVLNIDFKSMQGQDKVSVIVRAFRSLLSTFPRTFAFDNWFTNPKGHYRRIALVKTLTASLTPIVKEKF
DMAHNNIRLDNKVVDRSVMAMGLRQVHTLTPQVLEECVDAVKSFLFAGHDTTAVLLQWSIYELSRTPRALAAMRKELDEV
FGLDADPKSVAKQLLEDSNKLQNLQYTSAVIKESLRLYPPAGSARMVAPGSDFRLNTKDGPLDVGGMVLYVCHYAVHRDP
TVYGETADVWIPERWLGQTSTTSEDYAPSSVDKDKNSSTAGAEGQKIPISAWRAFERGPRNCIGQELANLEARAILAMVA
RRYDFTKIGIGSLALKDGKPVLNQHGQFEVTKPLFGAKNVDLGHLAYSGSSSDREGRMSARSVVYQVDSKVPINDV
>CYP587A1 Magnaporthe grisea MG10009.4
AACU01001316 cont2.1914
MTFCRRLQQAIAQFEVDYKLVRLGLVATAALIGIAVVYYAFVGYRVRSRFQRLQKQGV(0)
PMMPHNPILGHLPLMPKILAGLPADAATLFLPLQIQENWRSVFPES
VTELPPVVYLDLWPLIPPTVMSFSGDVSAQFTQEFNQVKLPDQKRFLMPL
TGTRDVSSAEGDEWVRRRKALNPLFSPQNIMAWVPELIVELEVFLEGLRS
RAGKEGGWGPMFRLQRPVQLFTLDMINHFCLSKRFHEQTTTMSVVSTGVL
DILSRQAMFLHIGNVWGYYSPWRLFKVWQQQQLMDDFFLPYVRRRFDTRA
KEDKASPSGNDRIDLPHVLFKAAEANSAKEDRKLQYVDVVRDVMGEAKLM
VFAGHDTTTFALTSAIKLLSEHPAALEKLRAEVEEVLGDRPADRIKEEPH
LLNRLVYTNAVIKETLRVHPNVGTLRIGAEGFSLYGPPGSGQEGVAFPVG
GYLLWDATSAIMRHEAVWPRAREFVPERWLVEQGHELHPGEYQKNWYRPF
EQGPRNCVGQPLAMAELKMAVACVVAEFDVECDWDEWDVVCGNVGPAAKK
FTHNGNRLYMVNEEGPPKFKDGMPVHVRLRSGKQ* 3789+
>CYP587B1 Fusarium graminearum FG04249.1
AACM01000185 FGcontig1.185_scaffold2
MLPLEYQHDGSSFLLHCLSFSGVVLAALLIHALRKGYQVRKKFKALEAQGI
PIMKHSMIFGHLESVGKLVSSLPPDAHGDYLMMMIRENWRELFPQCTKCPPVAYIDTWLF
TAPMVISLNLDVSTQFTTQHSLPKAYEQKHTLYQLTKNRDLASMEGEEWKIWRKRLNPAF
SIQNINSRIIDILEEVEDFAAVLKSKAGDDGQWGDVFLFEKATTNLALDVIVRFFL
DVRLNEQWGANSPMCHALQDTISRLCFFVHIANFIQYYNPWRQFX
LWKNYKTLADSMTPMIKERTRARQEDPTAKGKTLVDLVVQALQEEKAEQS
NTANEGKTQPGLEFDTEFMDMAIGQMNTFLFAGFDTTAATVAWLFRLLCQYPDVVAKLHD
EHDAVLGTNAWAAANVIREDPQLMNQLPYTLAILEESMRYHTNVGTMRRGEPGFFLVGPP
GSDPGFDGKKLPTEGFIVWDGTWAVHRDPEIWHRPDEFLPERFIITDREDPLFPPINGWR
SFVSGPRNCIGQHLLVLEVKLVMALVTRYFDVEVTWEKWDRAK
GTTNAKKAPTIWGDRCYQVGANALPRVKDSMPVHVRVRA*
>CYP587B2 Nectria haematococca
e_gw1.18.184.1
Necha1/scaffold_18:122860-124804
53% to 587B1 , 41% to 587A1
note: this gene is longer than most other P450s
and it may have added
loops in the structure. These appear to be conserved with
orthologs in other species.
MWLLTFRDDSTLTAAQVLSASIILLAGFLLRCINRGYQIRKRFQALKAQGI
(0)
PIIEHSIIFGHLKVVRKLTANLPPDAYPDYLQTQLQDNWRQLFPQ
CTKCPPVVYIDTWPLANPLIVSLNADVSSQFMQQHSMPRFRDAK
DFFHPLTKNRDVVSMGEAEWKIWRKRLNVGFGAQYITSRIPDIVEEVEQFVDVLKSRAGTGETWGPVFLL
EHATRNLTLDISVRFFL (2)
NMRLHEQRGNPSPLAVALEDTLSKMMFRVNILNVVPYYNPWRHFKLWWNYRTL
TQQLIPPMQRRLSELQADNTIPRKTLIDLIVQALEEEAAEEQGSSGGKPKDLIGLANDSLEVVVGQLNVF
MLAGFETTGSAISWVFRLLCQHPAVLAQLRQEHDEILGTDPWGAADTLKENPQLVNMLTYTHAVVRESMR
VYTNVGTVRQGDHAFFLTGPPGSGPGFEGKKLPTDDFGLWDGVSAIHRDPKIWHRADEFIPERFLVTDTN
DPLYPPPNAWRAFAAGPRNCVGQHLAMVEIKLVMAMVVRCFDIDCRWDEWDRSR(2)
GNKDTKTDHPTVWGDRYYQVGRYGPPRVKEGMPVHVRVRSQI*
>CYP587B3 Gibberella moniliformis, Fusarium verticillioides
AAIM01002228.1
FVEG_10439
4962
MWLLGLQDDGASLLTRLLRFSGVILVALLVHAFRKGYRVRKKFQALKDQGI (0) 5114
5167
PIMKHSMILGHLEVIGKLVSTLPSDAHGDYLMLKIQENWRELFPQCTKCPPVAYIDTWPF 5346
5347
TAPMVISLNAHVSAQFTQEHSLPKAYEQKHVLYPLTKNRDLASMEGPEWKVWRKRLSPAF 5526
5527
SIQNINSRLPDILEEVEDFANVLKSKAGKNGEWGEVFPLGDATANLTLDVIIRLFL (2)5694
5762
NIRFHEQWGKSSPVCAALLDTISRMYFFVNPANFIQYCNPWRHFKLWQNYRTLVKSFTPV 5941
5942
LQERMNKLQQDRTAKGKTLVDLIVQALDAERAEQKGAGQDDKDQLNMELDADFLEMAIG 6118
6119
QINTFLFAGFDTSAATIAWLFRLLSEYPDVLAKLREEHDAVLGPNAWGVAGVIRENPQLL 6298
6299
NQLPYTLAVLRESMRYHTNVGSMRRGEPGFFLVGPPGSDPGFEGKKLPTEDFIVWDGTYA 6478
6479
IHRDPEIWHRAWEFLPERFLVTDPEDPLYPPPNGWRSFEAGPRVCIGQHLATLEMKLAMV 6658
6659
LVARCFDIECAWEEWDQIN(2) 6715
6779
GTTNSEKARPTVWDDRCYQVGTDSPPRVKDGMPVHVRTRGL* 6904
>CYP587B3 Fusarium oxysporum (temp 587B5)
94% to CYP587B3 Gibberella moniliformis
FOXG_11378
MWLLGLQDDGSSLLTRFVRFSGVILVALLVHAFRKGYRVRKKFQALKDQGIPIMKHSMILGHLEVIGKLVSTLPPDAHGD
YLMLKIQENWRELFPQCTKCPPVAYIDTWPFTTPMVISLNANVSAQFTQEHSLPKAYEQKHVLYPLTKNRDLASMEGAEW
KVWRKRLSPAFSIQNINSRLPDILEEVEDFANVLKSKAGKDGEWGEVFPLGDATANLTLDVIIRLFL
(2)
NIRIHEQWGRSSPVCAALLDSISRLYFFVNPANF
IQYYNPWRHFKLWQDYRTLVKSFTPALQERMNKLQQDRTAKGKTLVDLIVQALDAERAEQKGVGQDSKDQSNMELDADFL
EMAIGQINTFLFAGFDITAATIAWLFRLLSEYPKVLAKLREEHDAVLGSNAWGVADVIRENPQLLNQLPYTLAVLRESMR
YHTNVGSMRRGEPGFFLVGPPGSDPGFEGKKLPTEDFIVWDGSYAIHRDPEIWHRAWEFLPERFLVTDPQDPLYPPPNGW
RSFEAGPRVCIGQHLATVEIKLAMVLVARCFDVECAWEEWDRINGTTNSEKARPTVWGDRCYQVGTDSPPRVKNGITSVT
KLYLSSYILELIQDTAWWHCSSFG*
>CYP587B4 Aspergillus terreus
AAJN01000219.1
ATEG_08901.1
5121
MGLLSNFQNHDSSYLLLQSVTALLVTASAYGLYRGYQVRSMFQSLKKQGI (0) 5002
4919
PLMPHSMIFGHLEVIGKLMSRIPSDAHGDYMMVLIQENWKELFPGCSKCPPVLYIDLWPF 4740
4739
APPMLISINPDTSAQCTQDYSLPKAYQQKRTLYPLTRNRDVSSMEGAEWKVWRKRLNPGF 4560
4559
SIQNITSRISDILEEVEVFVGVLEARAGNDGAWGEVFPLENATTNLAMDVILRFFL (2)4392
4329
NKRFHQQTGPRSPITVALLDTISRMYFYVNIFNFLSYISPWRHFKLWLNYRTLFNSLSPF 4150
4149 LTERINEIQKNSQVTNKTLIDLLVKAMDEEKGTNGAAGDLSTNTDFLETAIGQI 3988
3987
TTFLFAGHDTTASTICWLFRLLEQHPDILSKLRAEHDAILGPDPSQAAAALRANPQLLNA 3808
3807
LTYTNAVLKESTRVHTNVGTMRRGEPGFFLTGPPGSGPECEGKQMPTDGFVVWDGNFAIH 3628
3627
RSPDVWPRPNKFIPERFLVTDENDPLHPPKNAWRFFELGPRGCIGQHLAMVEIKLVMALV 3448
3447
VRRFDIECAWDEWDSKR (2) 3397
3356
NFKGPQNMVWGDRCYQVGGDSPPHVKDGMPVHVRVRG* 3230
>CYP588A1 # name changed to CYP534B1
no sequence
>CYP588B1 # name changed to CYP534C1
no sequence
>CYP589A1 Magnaporthe grisea MG08234.b 2
fused P450s poor match to second half
AACU01000307 cont2.1540
MEKGRVRISGDVTLS
PRDKDSQLVKIISTKPTMIVTIPVLLATYILYWTVRLVKNILRANATGLP
VRWTPVAPTNPFWIVLGKPTSRVLRAILPSFLSNWTYFSTFDWHWLDRLY
LDFEVHEKNGDTFLHATPSGLMLHTRDPQVAQQILHTCPKPDDVAKSLEL
CGPNLVSSSEVDWPRHRKVTVSTLSDRNNRLVWSETVRQTLNVLQSYQPG
HGEIIDPEGDIRRIYLNMFSAVCFGRPLDAEKEPGETTDGKLPGGHKRSY
RYCLETSLRDIFILHTVPSWIKYLPPALVPHKISEFFAASREMMQYLDEM
IRRCQDEAQEGGEESKSGDNLLRITVRSGLQSNTKEPQGRSYLSKEEVRG
NLLIYSLAGHESNAHTLTYALYLLAACPDVQDWLAEELAAITLLDGQLSA
EETYFGIMAKLPRTLAVMYETLRLYPSIIFLPKTTASRSVSIDLGHVEGQ
SKAIIPPNTNIWVNMCGMQVLPEVWGDDARTFRPSRWINSSGQLAAPSLV
AGSAYVAWGGGKRVCPGQRFSQAAFAASVVALLTGGKRVHVVPREGEEEG
MARRRVLEVLDDSFVGTTIHMRRAGDVKLVVA*
>CYP590A1 Magnaporthe grisea MG08795.4 poor match AACU01001208 cont2.1657
MGLFTFGIFLLVSVWISSHLKSLARNYSAAKALGLPLIIHPFDPDSVTFA
LLSEPLHAILVRILPSSAYAYIQPCFFGWEFQNKGAIHQRLGPAFVLVTT
GVNRLCCSDPTLASTFMTRRRDFVHADVSNHVMGIHGPNIISAGEDAWSR
QRRIVAPALNERISSDVWDESIEQASSLADFLVSSSSTPADDGASDTVPG
LRSVAINVLSRIAYGSVKTFNVWNPTYDPKADLSYVDGIALCTDLLVAAA
FIPAWILRLPVMPLSLQTLAAALRKLPDLAKNMLEQERERISSSPADEAA
TTTDTKKRRDTIMTTLLRLSDQAKEEAASGENKPTAEDGVSSVGSKAYLT
EPEIQGNLFVFTAAGFDTTANTMAYAVALLAAHPQWQPWIQAEIDSVVGS
ITCGQDGRLQVPEYGETFPKLIRCLAVMFETLRLYPAVSLLLRKTTVDQT
ITLPGPPLIQVPLKAPFTVQVNAMALHTDPEVWGSDALEFNPGRWVRPDP
ETPGGHVLMTPPKGYFVPWSIGPRTCPGQKMAQVEFVAVVMTLFGRCSAE
PIPGDGESSELARRRVLDVTEDSQPGLTLQMKKPRDIRLRWTRR*
>CYP590A2 Phaeosphaeria nodorum SN15
AAGI01000245.1
52% to 590A1 Magnaporthe grisea
128907
MGLLLIGIVAILLIWIMSHLRIFIRNYNAARATGLPIIICPYDPDS (0)
VVFTFISEPLRPLLKPILPASIFAVFDATCWGWEFHDK 129266
129267
GAAHEKFGDAFIMVTTGHNRLVCADPAMSQSVLARRKDFHHPELSKKTMGVLGPNLVT (0) 129440
SRDESWSRQRRIIAPTFNERISLDV
129626
129627
WKEGVQQASALVDHVLSSSTLSQSMTLSTSPAADKSSDSLPGLRAIAINVLTRVAYGRHT 129806
129807
PFSIASSYRDATKALTYVDGIALVVDLLLVAAFIPAGILRLPFMPQLSKKLGQAMVKLPD 129986
129987
LTVDMLDQERKRISSADSKEFQNTIMTTLVRLSDQGREQDDDQGSSGK 130130
130131
SVATGGNKQYLTEEEIAGNLFIFTAAGFDTTSNTMSYAICLLAAYPEWQAWIQAEIDVVL 130310
130311
GAGDHEQISLEDYTAIFPKLTRCLAVMFETLRVYPAVSLLIRTVETNQTIFPSSSKS 130481
130482
DSFILQAPCAVHVNIMALHTSRSTWGADTLDFKPARWFPEGQDSMYVPPRGTFMP 130646
130647
WSSGPRNCPGQKMSQVEFVSVVMTLFGKCSVEPVAEKGQTVKQARERLLGLLQDSQPVLT 130826
130827
LQINKPREVKLKWTRR* 130877
>CYP591A1 Magnaporthe grisea MG03811.4 poor match AACU01001028 cont2.745
MFSTAAIALSSTLAAWLLYRALLQKLYPSVLPGVPHNAVHAKHLLGDLPA
IDEYVSKNGCTKSEATFDTINRGTTNFPIAQMLTPNIMPHAILTVDDPRE
VEDILRRRAKEFDRSSMTAAFFKSLLPKATISLFTTPELKVQKKLWADSI
TSDFVKNVVAPHAYRAANRLVELWRLKAGSEFQAQPDLIDAMMDLMWATV
LGSDLGVTSSKLAATAAGIRAQDPGQLEKAASTSREMFFNVTSFLEGESS
YIRAGLEPLRTRVIQFLPRYHRVRKSMNQEMGNLISMARGRRGHERDGTE
GGVACAMDLVLERELQLAEKGNSVAATNLEQELMLFMIAGIDSTAFTLAW
CVKLLTKHQQVQQELRDGLVEAFGVGDNAQALPSPQDMASRDIPYLDAFI
HETLRMANTAGSVVRRATTNTVVLGCSIPAGTELVLNTRVLKTPIPVDES
LRSATCREAQAKRPRGGIEGPSGHNLEAFNPRRWLHPQPEGRDVFDPEAL
PTLVFSHGTRGCF
20908
GKRLAMLDLRVFIIVLVLEFRFMPIPENRNDWSAEEGIFRSP 20783
LQSPVKLSTYD*
>CYP592A1 Magnaporthe grisea MG07488.4 poor match AACU01000906 cont2.1392
MSNITFSGPSFLLGDREASLELTPKILGAALLAALLLLPVLWHSKTAPPG
TKPVPGPKGLPLIGNLLDIPKKHAWLKYREYIEEHGPIVRIKLMGQEHIL
LGSEAVVDDLLKSRGGIYSGRPQTQACSILTQDQHVLMMPAGEPLRVRRR
FLSQLLTRGAVSQYEPYQWLEAYRLVVEMVRDPSDYQGLIEHFSVAMGSR
ILFGQAMPDRSGLQKEVIKIGHTFEAVLTPGAFLVDVLPWMRHLPDLVAP
WKRWLKRMSRRDEAFYYRMWERTKADLDEGRDAPSWARLCLEDMKRAAVG
GKGMGITEHEAVHLIGVTYTAFGTTPANMLSLLLGMTRHPEWWLRMQAEI
DDVVGAERLPTLADLPRLPVLRAVLSEITRLWPVTPDGVPHELTQDDVYK
GYRLKAGSVIHYVTWACGRDPEMYPEPDTFNPGRWIDPSFPTYKEPLTEF
PTLMNTLMFGKGRRQCPGMIVGVRNVYVQTMMLVWACDLGRARDEVTGEE
IVPPLYDYGAGFNVAPNPFKFDLKPRGAGRMRMVEAAYEKALAEDPMKE*
>CYP593A1 Magnaporthe grisea MG02292.4 poor match AACU01000444 cont2.449
MFNLPAISVASGLALLYLIVSHLRTRRKPFPPGPPGSLILGNLLQIPTKK
ACLTFQKWSREYGSSSDGLLGLRMGPWARMIVLNKHKQYRDLLEGRSTVY
AGRGSVPIMEKLRVWTKPGEPYVGNFASWQYNDELKRERRATHEYITRSA
QVEKLLPIQDAESTQLMWDLLSFERDKKAGDTAPGSHHLLFFRTFGAVVL
AAVYGIRGKDTTHDSHLGQFESIVKDFIQLLALTAAPPYEVFPFVDYIPE
FINPWRGWILRGKEFRVRWFRFWKEFHDIALNSAESKTSREGDGMLLQLE
GKGYSDTEKLSFGATIMNGGADTTAITCLTMLGAFACFYEAVRWRPLTPL
MTRRVRQDHEYEGFFIPKDTMVLFNIWALSHDTDVFDRPQDFMPSRYLPQ
CRGDPDVKPLPVYGFGTGLRNCPGQKMAENSVMLVVAKLLWAFEISSPDG
KLDTSMETGYDDAFMLAPNPARLSFRLR
>CYP593-un1 Magnaporthe grisea
MG09380.4 poor match
AACU01001225.1 cont2.1796
pseudogene
9124
MTLFTVPMAAILLLLVAAVLLVPRIRSKSRFPPGPPTLPFLGNLHQMPTS
KAFLSYQEWSTTHAASSSGLLGFHLGPSAKLLVLHKWEQVRDLLDLRGAIYSDR
PYVPALD ()
YGPKWRRQRRTIDEFLRDRNAQLAPVQQAEGTQMVWDLLHHGRDCHDYMLRFSAAVILASVYGERGRD
()
deletion of about 165 aa
LRRLLGE (0) 8468
8357 TMRFRPQFPTSIPHATTKDDTYQGYSIPKGT
TVMMNVWALYHDPAEYEDPDSFVPERYLRNRFGTRHDHVESGQDDAKPQQ
GFRRDTWAFGAGRRACPGRRFAENTLLTLTAKALWRLTLWPWARWTWTSG
PGSRMRF* 7941
>CYP595A1 Magnaporthe grisea MG09156.4 35% to 68D1 AACU01001649 cont2.1746
MIAELLFNPGTWTALAVLAAAYYHFFLRSPALPFPPANKSASELQDASSL
ITNSLSKSNGGPVVVTLGSGGRKILLPSSLAAWVKTNRDLDHQQLVREDF
MSGIPGFEGNTLLHQSGSPIMDIIKTRMGLNDGTLRTLNASVKRTLHDTL
GEGAEWHAIDWYAGTSNIIARAASSVFVGPEKADDPEWLELAQTYVTAYF
TGVAELGTYPAWARSIVHWFLPNVKTCRKLLPRARVIIGQVAAAREKEAA
AARREGRPAPEYNDALEWVRAVSGGEVDPAEAQLCLAMAAFFTTAELLRV
LLIEVARHPEYVDELREEISTQISKHGLSVAGINGMVLLDSFMKESQRLN
SGPVVLERVALRDTALPDGRIIPRGSHIMVDSMDLWKSEKYPDPNKFDGR
RFLKKRKAGDSASQFVQSGPDYHVFGGGRHICPGRFFASQELKLIMAHLL
LKYDVRLGEGCDPKVIPNGFFVMIDPTVKFEVKRRKSRDADALL*
>CYP595B1 Aspergillus oryzae
GenEMBL
BAE58469.1
46% to 595A1
MFGQIFSSVFAWTLIAILAGLYRFTTKQRPIFPVVNDYRGDFFRRKAYREYNQNAKKLIVDGLAKHGSPI
TLRVPDGLKIVLPSALSEWVKTNRDLDHQELIREEYFAGFPGFEAQDTLHAPDGMLIKLLRTNLSQNEEI
VPTVNRHIGPALQHYWGDSGIWHTIDWEDDTTGIISRAAASIFVGPEKAADDEWQTVVQAYVREYFAAVS
ELHTWRASLRPIVQWFLPHASACRRLLHQSRAIMQEVVRKREREAQAAEDQGLVAPRYNDVLAWTMQVPD
NKHPAGDIQLALAMAALFTTTELFKQILINIARHPELVEPLRKEIKTSLLGHGLGLTALAKMELLDSVMK
ESQRQIPVTVGLERKVIRDTSLPDGTKLPKGSHIMVDATDMWNPEVHVNPEVFDGYRFLKRRHAGDKASQ
FVQSSREHIVFGGGRHICPGRFFAGTELKLCLAHILLKYDIRLKEGYYPQPMVLGVYAIVDPMTQLEVRR
REHTEDLVF
>CYP595B1 Aspergillus flavus
99% to CYP595B1 Aspergillus oryzae
AFL2G_01662 revised
MLGQIFSSVFAWTLIAILAGLYRFTTKQRPIFPVVNDYRGDFFRRKAYREYNQNAKKLIVDGLAK
HGSPITLRVPDGLKIVLPSALSEWVKTNRDLDHQELIREEYFAGFPGFEAQDTLHAPDGMLIKLLRTNLSQNEEIVPTVN
RHIGPALQHYWGDSGIWHTIDWEDDTTGIISRAAASIFVGPEKAADDEWQTVVQAYVREYFAAVSELHTWRASLRPIVQW
FLPHASACRRLLHQSRAIMQEVVRKREREAQAAEDQGLVAPRYNDVLAWTMQVPDNKHPAGDIQLALAMAALFTTTELFK
QILINIARHPELVEPLRKEIKTSLLGHGLGLTALAKMELLDSVMKESQRQIPVTVGLERKVIRDTSLPDGTKLPKGSHIM
VDATDMWNPEVHVNPEVFDGYRFLKRRHAGDKASQFVQSSREHIVFGGGRHICPGRFFAGTELKLCLAHILLKYDIRLKE
GYYPQPMVLGVYAIVDPMTQLEVRRREHTEDLVF
>CYP595B2 Fusarium oxysporum
55% to CYP595B1
FOXG_08910
MAILFSPLGLGVSLVAILIGAIIFVNKKTKFPIINKYPKDFFHRRANHEYKTNVRKLLKDGAAKHGENPFAILVPNGIKT
ILPPSCVGWAKNNKDLDHQQLVRDEYFASYPGFDVQHVLHHPNRMVINMVQGKLSKTDKTLPVMNEHIKAGLSDIWGEGK
SWKTLNWEDGTTGVISRAAASIFVGPELAADPEWQKVSRAYVLDYFGAVGEMHLWPSWLRWLVVWYLPGASACRAGLKRA
REMVNEVVQKRRQEEQEAKLEGKEAPAYYDALAWTLESPLGNEFEPADVQLALAMAALFTTSELFRQILTEIARRPEVVE
HLRREIEDVAPYHDFTATSLVKMQLLDSFMKETQRQIPSLVILERLVIHDTRLPDGTVLKKGTHIAIDSREMYDPAKFEN
PEEFDAWRFYKRRQAGDNTSLFVQSSPEHAQFGMGKHLCPGRFFAGSELKLCLAQIILNYDIRLKDGCSGKSMQFGFLSA
TDPYTQLEVRRR*
>CYP595B2 Fusarium verticillioides
90% to CYP595B2 Fusarium oxysporum
FVEG_06528
MAFLASPFGLGVSIIAILIGAIIFAKKKPKFPIINKYPKDFFHRQAHHE
YKTNTRKLLKEGAAKYGDEPFTILVPNGIKTILPPSCVGWAKNNKDLDHQQ
LVRDEYFASYPGFDVQHVLHHPNRMIINMVQGKLSKTDKTLPVMDEHINV
GLLDIWGECKSWKTLNWEDGTTGVISRAAASIFVGPELAADPEWQKVSRA
YVLDYFGAVGEMHLWPSWLRWLVVWCLPGPAACRAGLKRAREMVNKVVQK
RRQEEEEANKQGKEPPAYCDALAWTLESPLGNEFEPADVQLALAMAALFT
TSELFRQILIEVARRPEVVEHLRREIEDAAPDHDFTSTSLVKMQLLDSVM
KETQRHIPSQVILERLVIRDTRLPDGTLLEKGTHIAIDSREMYDPTKFEN
PEEFDAWRFYKRRQAGDNTSLFVQSSPEHAQFGMGKHLCPGRFFAGSELK
LCLAHIILKYDIRLKDGCLGKPMSFGFLSATDPYTQLEVRRR*
>CYP595B3 Aspergillus terreus
72% to CYP595B1 Aspergillus flavus
ATEG_02452.1
MLVELLSNGFTWSLIAGVAGLLLLFTKQRPVFPVVNDYPGDFLRRKAYREYNKNARKLIADGLAKHHGPITLLVPGGMKI
VLPSALSDWVKTNRNLDHQELVREEYFARFPGFEAQYAAHSPDRMLIDMIRTKLSTNETILPTVNQHLATALQEHWGSSG
VWHVINWDKDTTGIISRAAASVFVGPEKAADPEWQTLVQTYVREFFTAVGELHAWPAVLRPVVHWFLPRMSTCRALVRQA
RATMRDVVYKREQEAKAGRERGLEAPQYNDVVAWTQNVPSNNLPAGDIQLALAMAALFTTTEALKQVLIDIAQHPELVDP
LRQEIKQSLSDQGLGLAALGKMELLDSVMKESQRQIPVSVGLERKVIRDTFLPDGTRIPQGSHIMVDSGDMWSAEVHDNP
ESYDGYRFLKRRQAGNKKSQFVQSSREHNTFGGGRHICPGRFFASNELKLCLAHILLKYDVRLKHGYCSRPVQFGVYASV
DPVAELEVRRREVPDDNVL*
>CYP595C1 Mycosphaerella fijiensis
47% to CYP595B3 Aspergillus terreus
e_gw1.7.216.1
MEAKRSDWGLDLLHEVRSWIYILALLGTIVYYWRSRSAIFPVVNKYSWDFTRRKAHAAYMQDARGLIARGLREKKGPITL
DTPSGPRIVLPSSLTDFVKNNKDLNHQELVYHDFFGNYPGFEANAVMHNPDNVVIDTIRKKLSNNARLIPIMSEHIGEGL
AGIWGDAESWHALDWVPDTMKLVSRAASCAFAGEHLARDAEWQRLTQTYATNFFSAAFELKRWPHWTRPTLHWFLPGATE
CRKLVKDVSIATQAEIDRRRKEKDAGAETDYPDAIIWAQEIAGDKKINHGAIQLAFAMGALFTTSEALRGVLIDLCEHQE
LIEPLRKEVREALSTSGVTLAALAKMNLIDSVMKESQRLGPPSIVGLERQATKDVYMPDGTRLPRGTILAVDSSDMWNPS
INPDPDVYDGYRYYRKREGGDNQTCFVSSTREHNVFGMGKHICPGRFLAAVEIKLCLAHILLKYDIRLQRGCEPETIKNG
LFQMVDPAAKVEIRRTSGGEAKLL*
>CYP596A1 MG10351.4 39% to 68A1 AACU01001708 cont2.1991
MNFSSLLLSVALLGASLFIIGYWFYERVYTEWPWSGFPLAVLPGKGRKPK
ESYMESASRTIAAGLEKYSGPFQMITSTGPKLVLPHKYADEIRNRPELDF
NEAFRKDFFAHYPGFDGFKASLDNPFLIPQTLRLKLTPSMGLVTHHLVDE
ATDALHGIYGEDPNWRSVTFKQNNLDLIARLSSRVFLGKPICRDKQWLEI
AKNHTVDSFLAARDLRAQPFFMRRIMHRFMPHNVNIQRHYADASRIISTE
VENRRRRAEQLLSEGKKPPRVSDAIGWMVEVAKGQKVDYVAAQLSLTVAS
IHATTEALTVALMDIANYPELKKQLREEVIQVIREGGWSKQALYNMKLMD
SFLKESQRFHPPSDVTLNRKVMQNMTLSDGTRLPKGAIIMVASKLRDPKI
YERPNEFDARRFLRLRDDSNNANQVYQNARVHADERGVTKGHGRHACPGR
FLASSELKVALAHMLLKYDWELDETDKMPKFFDNETAHMTSPMVKLMIRR
RKEEINLDLDEGLNLSDIED*
>CYP596B1
Nectria haematococca
fgenesh1_pg.scaffold_19000057
Necha1/scaffold_19:141600-144731
43% to 596A1
MLLSTMFDFFQRSPSGETNTLSLYLQTLLLGVVSWLAFFYFSKPKYYSGFPIVSSEAKGTPATRWFLEGYQMV
LRGLKTVSGPFQVMTGTGPILVLPNNYANEVR
NNPHLSFNRFFDKDFFVKYPGFEAYKTGYQDGTFIQEVVRTKLTQSLGLVTDDLVDEMTASAHDLIGEDK
EFKAVTLKEVISLMVARLSSRVFLGKNLARNDRWLHIAMHYTHDSYSAAAELRQWPFFLRPFVYWFLPLC
RKLRQEVKDADALIMPEVNRRKEAVLKAQASGEKPPRTSDTIGWMFEISRGRDVNYVYGQLFLSFAAIHT
TTETITGCVLDISSYPEIVQPLREEIISVIGEHGWAKTSLYKLKLMDSFMKESQRRHYMGM
(1)
TSIHRHADEDIKLSDGNVIRKGSRMCVTAEPFIDPKVYPEPEKYDVYRFLNLRSQPGQENAHQFVTTSPQHMLFGHGTH
ACPGRFFASNEMKIALCHLILKYDWKLCDGQTERPKNLQVDAGFLTDPTVKVMVRRREAEIDLDVGIAEE*
>CYP596C1 Mgr014 Mycosphaerella graminicola
47% to CYP596B1 Nectria haematococca, 43% to
596A1 N-term from JGI model e_gw1.7.728.1|Mycgr3
MANDLITYLLDVRPFSSFLLIGIGIITLVFARWALIRPKPVPGIPVVLAAPKGWRGLGEQNAFIQHARTILKQGLRECTGCF
QVWTSSGYKVVVPNRFADELKSHPDLSFNEAFQEPFFHLPGFEDQYQALQNDWFIQDVVRIKLTQSLALVTDALVEEAIFSSHSYLGDSMSWSTIRPKFFVLDAVSRLSSVVFLGKKLARDKSWLQIAKDHTVDSFAAQDILRAVHPLLRWPTYYFDLTCVRLRQQVKTSRKLIAPEIEARRKRAVEAQKEGRKFTKESDAISWMVDIAKDMPVDYTAAQLALTTAAVHTTSETIANCILQLCEAPEIVPALRAEIIDVLNERGWSKTSLPRLKLMDSFMKEVQRTHAMAMTSMKRKVKKSITLSDGTHLPAGITIMISDDKTHDGEIYSNPAEFDAERFLQLRQQPGEENRHQFVTTTAEHLSFGHGQHACPGRFFASNEIKIFLCVFLLSYDCQFVPGEKRKNALEFETSMMVDPTTEVQVRKRTPEIDL
>CYP596D1 Mycosphaerella fijiensis
42% to CYP596C1 Mycosphaerella graminicola
41% to CYP596B1 Nectria haematococca
gw1.2.702.1
MTSIILAQFPSSLNYVLCLTCIGLSITLIIYFSRHHSPKPVPNIPILSHD
RDEYFRRGYDLVKEGQEKFPGCFQLRTATGWKILVPIRFIDELRNNRFLSFAKGNDKDAFIDYPGFEAMEAACHDDYFMQ
EVVRVKLTQSLNLLYSSVIDESAATMSEVLGESKEWRTCRIKDLVSRIVARVTTRVFVGFPLCRNQEWLDLVVNHTAAVF
LAQKRMRQTPPALRPLVHWFLPETRRLRRELRAARALITPEIARRRAAVEEALQHGKIPKESADAISWMVEVAQAQGRKS
DVAVHLVSLSMTAIQTTSEVMTNCILQLCETPSVVADLRAEIIPLLREGGWTKHTLYKMRLLDSFMKEVMRHHDFLRVTS
WRGCTEEVTLSDGTVFPKGSCIYFDDSNVVNPEYYPDPEKFDATRSLKKREQPGQEERHQFVSLQTDHMPFGYGTHACPG
RFFANMELKVMLCNFLLKYDVRLVPGEEHRPADILFEVQRMVPPDCRAQIKVRDVEPEVDLYSPESSI*
>CYP597A1 Magnaporthe grisea MG01700.4 36% to 68D1 less to other 68s
AACU01000096 cont2.318
MTQWELVFGMLAEWQLEILVTITVLIAGSLLYLDRPAVYPGIPLMGAGKG
WFGYRQAVNKYRVNGREMVREYSKTNKPFQVITDTTTKIFLPAEYTEEVK
GIKELSFGKGLSIELFGGYRGFEAVAALGDDESNIIQTVSRLKITTSLKY
LTDEISDEASAALQEQLGDNIQEWQEASVKPIVRNLNARLSARVFVGPEL
CRNKAWLDVSTSYAAQCGVAAFKLQAWPRVLQWPVSLFLPECRVLRRMAA
DARRILAPIASNRSDKPVDPKHRGGDTILWIQEAVSKAKMSHKYSVADFQ
LGLSLAAIHTTTELLTNALFDIVTTGPELIDELRREIIQVFNGEGGIASY
NEEEVFTKERLYKLRLLDSTLKETQRLRMSRLGGMPRVATAPITFKSGLA
IPAGAFTHVLLTAHMDPSIYWSPETYDPRRFLRLRSQPGQDKNWQMVTTS
PHHLAFGYGEHACPGRFLAAAQVKIALVRLLMEYDWRFDGGRPESLDVGG
GMNWANPNAKVSFRKRKAEVAF*
>CYP598A1 Magnaporthe grisea MG10345.4 poor match AACU01001708 cont2.1991
MELPDFVWTWGPLLATFGILLAWNAVSLRRSFQTTSNYPIINYQKRSWTY
AAARRQFVHNARQLLVEGSQKFSGPFKVITLSKPLIILPPEYIDAINAER
KLSFLEYVREEFLSDFDTFRTCRPMPPGMFSKAIQNGINRRLPKFTQGMS
SELSACLDKSLGYQQGWHEVNFINEARGWVAHMTTLVFLGESFAHSQQWI
DVTTSFVENMFMAMAITRSFHPLLRPLVDRFSPLNRKVRKYQEVIASILG
PVIQERHMQIKVAEMKGQKPDLPDDSIEWFRQAADGFNYPEIWIQMGLNQ
VSMQTTSNQLCQSILYLCANRQYFEPLRQEAIEVLQRDGLEKAVTNMHSL
TFMDSFLKEAQRLKPEGLASMHRRAMEDVQLGPDVTIRKGEHLAISAHQM
WQESNYPNPEHFDPYRFIERRKNPKYANRWAFVSTSPDHMGFSHGKLACP
GRFLASSVLKIAMLHLILKYDLRIADPKEATPWFHGTYAMVNTNARIWVR
SRKPEVDLESLARQIQHE*
>CYP598B1 Mgr069 Mycosphaerella graminicola
55% to Mgr073, 44% to 598A1, 39% to 68L2 N-term from JGI
model e_gw1.9.207.1|Mycgr3
MTTIELLRGAVNTIVGPERIIPWPATLAIAAVGWWILSSWLRPV
SKFPTINDPKENWTSFPAKKAYLKNCQHLLKEGARKFSGPFNLTTDNGTTMLIFSPEYIDAINEQESLSFPEYAIRNLNL
KGYKTFRTFGPQPDHMFYEAVIKGLTRNLAKFTKPLSLEMDACLLSSWGESTEWHSVEAKEDVLDFVARLSSLIFLGPDF
VHNKEWIRIAKNYTVDTFTAIAICRYIPALIRPLFVQFLPLCRKVRRDYTTCANILAPVLASREAELKAAKSESRPPNLP
DDAIEWFRNAAHGREYNQTDVQVSLQVASIHTTTDLLAQAILNLCAHPEMVVPLREEAIAVLSTQGWQKTALTSLHLLDS
FLKETQRLKPINVTSLHRYATRDTTLSGGIHIPQGTNLGIHSYNLFNPDIYTSPETFDGYRYLRLRQSDPKWEHKGHLVS
TSVEHTGFAHGKNACPGRFFAANEVKIAMVHVLLKYDVKVERKEDAMWITYGPNCYVNPKARMWVRRRREEVDLEALARE
>CYP598B2 Mgr073 Mycosphaerella graminicola
55% to Mgr069, 41% to CYP598A1 Magnaporthe grisea, 41% to 68D2
LQPKSRYPIINAPKTSWTSIPAKIEYLKNTKHLIIEGYRRSSGPFKLQTEHGISVVLPPSALKMVDRSEIGLSGPEFLRRRFLSTYTTFQAMGNPPHDLLPEAVLRGLTRSLPKFTKPLSLTMNDCLASSWGSASDWQERALMDDTLLWVARLSTRVFLGERFVQNAEWIRIAQEYTIDFMTATAICGFVPALIRPLFVLGLPWCRKLRRDHAICERMFGPVFAEREAEIEAAQREGRVPDLPDDAIEWCRNAGKGRKYPQLNSQLTLSIAAIHTTSDLLGQTVLNLCVHPELLEPLRQEAISVLKSYGWQKQALTELRLMDSCLKETQRMKPVQLASSNRLATRNVTLPDGTFIARGEVVTFSAHDHFNPDIYPEPEKFDGYRFLKRRAIPGLEHKSVLVSTSEEHSAFSHGKHACPGRFFAANEVKIALVHLLLKYDMKIEKPEMAEWFTFGANTIANSKAKILVRRREAELDLEALA
>CYP598B3 Mycosphaerella fijiensis
53% to CYP598B1 Mycosphaerella
graminicola
49% to CYP598B2 Mycosphaerella graminicola
estExt_fgenesh1_pg.C_110219 revised at N-term
MVEESRLWQSLAEGVFHVQREIIYGVLVLILGLFWIVSSLRARGTHFESINE
KKSQWWNLNYKARKDYIQHARRLLSDGFRQ (0)
FKGPFSILTDGGRIIMLPPEMIDAVNEKSELSFQRFTEEHFLAKYDTFRTFRSPP
PGLFEEAVMTGLTRSLPKFTKALSKEMSSCLDDTWNPILSDNEWHEIDIRKDILKWVARLSTRIFLPSHFAEDPEWLRVS
VEFTTDAFMASTICRFMPRIIQWPMERFFPLCRKVRRDYRTAASILQPVLDERHKEISTAQQEGRKPNLPDDAIEWFRNA
SHGTKKYHEVDIQLSLSVAAIHTTSDLLLQALLNLGTHPELLNPLREEAISVLKKHGWQKTALHDLHLLDSFLKETQRLK
PINMVTMHRTATSPVHLSNGLKISQGARTAISSHKMWSASIYADPETFNAYRFLDPTMGHRRHLVATSPEHLGFAHGKHA
CPGRFFAANEVKIAMVHLVLKFDFKLEDAGMARWVEYGTAMIANPKAKMWVKRRRDGGIDLEGLAM*
>CYP598C1 Mycosphaerella
fijiensis
38% to CYP598B3 Mycosphaerella fijiensis
38% to CYP598B1 Mycosphaerella graminicola
37% to CYP598B2 Mycosphaerella graminicola
e_gw1.29.34.1
MGYLISNFIDGTYWISSTSVLVACLSLAGAWTAARHWTSPWKKPRYPTINREEWDLFRHRATQQYITEARTLIKRGLHKY
RGPFTIITTGEPVLVLPPQYTKAVSEHPALSFGDYAQNDNLAFRTWTFSAAKSISVLPEPVLKGLSRKIPTLINTISSEV
SDCLDEMWETTPDWHEIPIKQNIIPCIARLTSRIFLGPTISSNPEWIQTASDYTVDIFLALERVKRWPRPLYFLAEILEP
ACWKARAQYATAARILQPFLQNREESLAQDQAVPEDSIEWIRNFATRKLCSDVDNQLGLTITSVHTMADLLTQAIINLCV
YPDIVPALRAETVRLVQKNADGMIDKSALNDADLLDSFLKETQRLKPFASAALFRRASCDVRLDDEVFLHKGQNVCVAHR
MWDEERYEGAETFKYDRWVRCGGEAGEGLHKRLVATSEDFTAFGHGRHACPGRFFAAAGIKIALMQILLRYDLKPLEWEE
GDLVEHGFSMTTNPAKKIFVRRRGGVGDV*
>CYP598D1 Mycosphaerella fijiensis
49% to CYP598B3 Mycosphaerella fijiensis
fgenesh1_pg.C_scaffold_10000124
MDTPTELNSSGEPLQLNAPNAAIHHILAQLTEAKAPSLGLYAAV
VITVLLGAQVLQYIIARLRRPKLPTINKFPWDPFGDKAKTQYLSHAKKLIQDGFKK FGERPFYLR
MEVDKTVLLPPQYIEAVNKEDGLSFIAFTTTHFLSHFETFKGLDGTTSMPGHFEEAIMKGLTRSLPRFTIPISREMTGAL
NDTWGNNKEWHEVWLRGDVLKWVARLSARIFVGDPLASDETWLRISREYTSNLFGAVDKVKSYPRPLWWIVERFHPLARQ
TREDRRQAKQLMEPYIAARNEEIARAAKEGRKPDVPDDSIEWFRTSAKGRPYKDVDIQLSLTNAAIHTTSDLLGQSILNL
CKYPDVIPHLREEVIQVLQKYGWQKVALTEVRLLDSFLKETQRFKPVGMVFMARKATRNVSLPGGLNLPKGTDTAVSSHQ
MWSPDIWGDDHDQFNAWRFVERRKQTPFQNSSLLVSTCPEFTAFGHGKHACPGRFFAANEVKIAMMHLIVKYDFKFEDPK
DADWLEFGVTMLANPAAKIWVRAREPEIDLDAVGVMGAEVEVEA*
>CYP599A1 Magnaporthe grisea MG01950.4 34% to CYP54A1 38% to MG08459.4
AACU01000379 cont2.368
MSEFPFSSPSTGVFALSKPSHLFAAIALAAALLIVRRLLKPDPYANYPQW
GEELGGFAKRRTYYLHNAAEVYYDAYRKFKSRICKLTTLDGDILLLPIKY
ADELLKLPGDIVDSYELLSSRIESKILKIKPENEYLVHVLRSDLNRQLPR
LNDALADAARTSVLETLGDSEQWTEFSVYRRVMEIVAVVSGSIFIGPELC
RNKEWLEIGIRFTIDLFHAATALKVYPRFLRPVAKYWCPEVFAVHRHTSK
AAELLMPVIENRRGLRDKDPSIVSNDLIHWLVNKAPKWGKDTTEFLVHSE
LQLTMASLNNTTAAITHFLYDIAAKCPEVVPELRAEIQTALDKHGGVWSA
QALFSIKLLDSVMKESQRFNPNLMITPRKILKPIEFRDGTRIPAGVNVCV
AGYAALQDGDFYKDPATFDPYRFLKLRTGETEDPLQYASTEQYQYVSVTK
ENMIFGYGLHTCPGRFFASSAIKMICGQILLQYDVKLPDGVTERYRNLIT
GHFINPDTTKSLMIRKRVM*
>CYP599B1 Magnaporthe grisea MG08459.4 poor match 38% to MG01950.4
AACU01001260 cont2.1594
MEDVQELLRSKLQFGLLIGALVVGGLTLWPWIADDRALRKFPLVDQEFGS
RSKRRNRFVQDSIGIYEKGYKMYRDVIFRITESAGEVIVLPIKYLEELRK
IPDDIIRATEATEDVIQTKYLHTTPEDPLLNHILRADLTHKLSQLNERLC
EEAARTVPEFLGKNREWTAIKVNATLLQIVAIVSGNAFVGPDYNRDEGFL
RTTINFSVDLFGTAYQLRAWPWFLRFIGQYRLPGVKAVKEHKRRAKEFLE
PIIKERRARLAAQEGYQEADDMLQWMIAKADKFNVVSDADLADLQLTLSM
TAIHTTTMMTTWVLYDLMYFCPEVIEDLRTEIKTVLARHDGALNTQAMSE
MMLLDSVMRETLRYNPVNVRAFQRYVRKTVKLSDGTVLPKGSHIGTPMHN
VHFDPDLHPDPLVYNPYRFYDIRTGKVPDPLGYSDPKQHQFVSLNKEINT
FGYGRHACPGRFFASNEMKLLLARILLDYDIKMPEGQTTRYQNVVSSGAV
MPDPTRDLMFKYIGK*
>CYP601A1 Magnaporthe grisea MG00238.4 31% to 54A1 poor match AACU01001391
cont2.57
MFVVRPGVDLLVQRPWIAVFLAAALLTAVCISRRRKPDDLEHIPCSGQGT
PRKRLQEYRLHAKRLYGDGYKKFQSLYRAANRIGYYVCVPYHLLKSYASA
SEEVLSPHAPFEEFVEASITQINVTSQALIHS
VKRDLTPSIATGKATPEL
SRVARDAVLSEIPQSSDWTEVDVHHQLVRIVTIVSGWMFVGPDFCRTDEY
MDLAAHYAADAFGGPLVLQMFPKALRSIVAPLVPPVRRVWKAHRRIAALL
GPAIAQRQRNTGPGSQPAPDDMLQWLIDNRHQFPDEIKGDGDIARLQLAL
NFVVASLYDLAAEPEIMQDVREEIHRVLQEHDGKITSKMLFDLKLLDAVC
KESQRLNPADLRMCLVPYPPPPNHVTQSDHRCSVSARRRVMQPFTFSDGT
AVPVGTMLAVPVYHIGRDPALFPQDPEKFDPYRFTRLRSKDAEGGGNHLQ
FASVTHGTMAFGWGKHACPGRFFAAAEIKLILLHMLLNFEVSVVPGPDGV
KRYPNVEMGNMNMPDFKRRVLFKSIRG*
>CYP602A1 Magnaporthe grisea MG09198.4 poor match AACU01000639.1 cont2.1756
MQTVNHSSAIFGRYNFFSRMDATMEGPAGDQIGTQFHHLS
49369
YYIALACILLGAYFFKLQKNAKRSQVDAPYYKASIWKWMFDAETQIIESYNK (0)
FYGKVYQIKATEGMQLVLPPAFVAELKSLPEETLSATAAMCE (0)
AMLSEYTHFHFANNGDLLAAL
49939 VKTKLAQNATNSTIVPRLKEEIDVLV
AEEFPECRDWTTFKIQPFTLRAVTRMAGRIFVGPEINRREDWVETNINFV
VHVFMTVAKLQFMPQFLRPIGQYLVPDVRRTAADLEKAGNLLKPIIDQRM
RDKENFPGYEAPADMISWLLETLSDKDRADIAVHAQLQLMLAMASGHGTN
NIIVDCIFDLADDPDLQDELREEVEAAYATGAPGSDWTKEKLLMLKKMDS
LMKEVQRFRGNLI 50655
50738 GFHRKVLKPISLSDGTYLPPGTKLLVPQAGISRDGAF
YQYPDHFDPMRFYKLRQQQQQSSRDSSGSGDEDSARHHQFTAIVDTNVNF
GGGKHACPGRFFACTEIKLLLAYFLRNYEVRLKPGEGRPKPFTMMMSKVP
NPDGEVQFRRRECAEY* 51199
>CYP602B1 Fusarium graminearum FG01868.1
AACM01000100 FGcontig1.100_scaffold1
MQNTSSLPASPVGVNVQYPQLVLEGKRTGYYITFTLFILTLWLILPKKQR
SQLEVPFYKASKKNWIFDAETLIKDSYTKF
RDRVYQIKATEGVQVLVPAS
LVGELKGLPEDVLSATEAVSDALQSKYTKFSPGHNGETLALLIRTKLTQN
LTRVVPRLREELEYILATEFPACEDWTPVKWQPFSLRAITRLSGRAFVGP
SLNRDEKWMDTTINFAVHVFTACVKLQFIPEWARPVGQYFVSELRQIRKD
IKIAKELLEPILKERLQNMELSNGEDAPDDMIQWLLEALPKDEKSDLTTQ
AELQLIIAAASIHTTNNLLCECLCDLAAYPEVQEELRQEAYQILEAENGW
ERKESLAKLKKLDSFMREVQRLSGNITNQYAASFIRKVMKPISLSDGTQL
PAGTKVLAPQAGIALDERYFPDPERFDAFRFYKLRQESSE
ANHRWQFTSL
DDTYTNFGAGKHACPGRFFANNEMKLVLAHLLINYDIRLKPGQDRPKPMT
VVMAKAPSPDTELEFRRRSLVA*
>CYP602B2 Nectria haematococca
e_gw1.13.286.1
Necha1/scaffold_13:161330-162748
78%
to 602B1 small gap after GNIT (5aa) check Fusarium graminaearum seq for error.
MENVSSLLASPISVDVQLPQVVTGGKRASYYITIAIVLLAVWLIRSRRKPLELEFPFYKA
PKTKWIFDAETLIKDSYTK
FRDRVYQIKATEGVQVLVPARLVGELKVLPEDVLSATEAVSD (0)
ALQTKYTKFTPGHNGDMLALLVRTKLTQ
NLTRVMPQLKQELEYILATEFPACEDWTPVKWQPFGLRAVARMSGRAFVGPSISRDEKWMNTTINFAIHV
FTACVKLQLFPEWARPIGQHFVSELGQIRNDIKTAKEMLLPILEERLRDMDMPGSEDAPDDMIQWLIEGL
PEEEKADVTVQAELQLILAAASIHSTNNLLCECLCDLAAYPEVQDELREEAYRILEVEKGWEKKENMAKL
KKMDSFMREVQRLRGNI (1)
TSFIRKVMKPISLSDGTQLPPGTKVLAPQAGISVDERYFPNPERFDALRFYNL
RQESDEASNRWQFTSLNDTNINFGAGKHACPGRFFAGNEIKLVLAHLLINYDIRLKKGEDRPMPMAMVMT
KAPSPDAELEFRRRSLAV*
>CYP602B3 Fusarium oxysporum
84% to 602B1, one frameshift
FOXG_04264 revised
MENVSSLAASPIGVDYQLPQ &
FVSEGHCTGYYITITIFLIAIWFFLPKKQTSHLEIPFYKASKTKWIFDAETLIKDSYTK
(0)
FRDRVYQIKATEGVQVIVPARLVGELKGLPEDILSATEAVSD (0)
ALQSKYTKFSPGHNGELLALLVRTK
LTQNLTRVVPLLKKELEHLLATEFPVCEDWTPVKWQPFSLRAVARLSGRAFVGPSINRDEKWMDTSINFAVHVFTACVKL
QFIPEWARPVGQHLVSELRQIRKDIKIAKEMLKPILEERLRDMEFSNGGNAPDDMIQWLIEALPEEEKADLTTQAELQLI
IAAASIHTTNNLLCECLCDLAAYPEVQEELREEAYRVLEVDNGWENKESMAKLKKLDSFMREVQRLSGNI
(1)
TNHYIASFIRKVMKP
ISLSDGTELPVGTKVLAPQAGIALDERYFPDPERFDAFRFYKLRQESAEASNRWQFTSLNDTYINFGAGKHACPGRFFAS
NEIKLVLAHLLINYDIRLKAGEDRPKAMSVVMAKAPSPDTELEFRRRSWAA*
>CYP602B3 Fusarium verticillioides
97% to CYP602B3 Fusarium oxysporum
FVEG_07386
MENVSSLAASPIGVDYQLPQFVSEGHCTGYYITITIFLIAVWFFFPKKQT
SHLEIPFYKASKTKWIFDAETLIKDSYTKFRDRVYQIKATEGVQVIVPAR
LVGELKGLPEDILSATEAVSDALQSKYTKFSPGHNGELLALLVRTKLTQN
LTRVVPLLKKELEHLLATEFPTCEDWTPVKWQPFSLRAVARLSGRAFVGP
SINRDEKWMDTSINFAVHVFTACVKLQFIPEWARPVGQHLVSELRQIRKD
IKIAKEMLKPILEERLHDMEFSNGGDAPDDMIQWLIEALPEEEKADLTTQ
AELQLIIAAASIHTTNNLLCECLCDLAAYPEVQEELREEAYCILEVDNGW
ENKESMAKLKKLDSFMREVQRLSGNI (1)
TNHDIASFIRKVMKPISLSDGTKLPVGTK
VLAPQAGIALDERYFPDPERFDAFRFYKLRQESAEASNRWQFTSLNDTYI
NFGAGKHACPGRFFASNEIKLVLAHILINYDIRLKAGEDRPKAMAVVMAK
APSPDTELEFRRRSWAA
>CYP603A1 Magnaporthe grisea MG08385.4 poor match about 40% to MG08379.4
AACU01000341 cont2.1578
MKLRVSQSPTPQMVITMLHGTFKVDADMCEIPKLFCTKGTSKYDNSSSTY
SLLASKKRNSNVVGQYIKNGIPFRMRNPADPSQPQVILPFKYLSEMKNAA
ESSWSFMHFSNQSFLLEYINAPLGSSIAHQVVRGELNKNLDWTALQPYML
FANTIARTTSLVLAGPELSANPEWTTIMVTFTMTLMQTSQEVRAKYSPWL
RWLVPWIHPGAKNLYKIRKRCAQLLAPSYQNRRAGMVGDEKPFMDAIQWL
MNKRTYKSKDLMKLSDDQLFLSVASIHSTSASTLSTLYDLLDRPECMDGI
LHEIRTIRAESKSSDWTKHDLDRLVKLDSFMKESQRYHPVGQVTVQRSNP
RAYEFSDGLKIPANTQTCFLSYELNHDPDVYPDPETFDADRFLRMREKVD
PQKYHFAYVSEDSINFGAGAHSCPGRHFAANEIKLMLCELLLGYEMKWPD
GQSRPPTMFHDFSSNPNPGFDICIRERRL*
>CYP603B1 Magnaporthe grisea MG08379.4 poor match about 40% to MG08385.4
AACU01000340 cont2.1577
MLDMSQPGLLTTKALFVLAVAGITLAVCRLLLRFNVLPFGNDVPPATADQ
LRHIPLLQFDGPNGVERYVSETRSLLRKGYEKYLRRGVPFQMRNPVEELG
AQVVLPPKYLDEVKRAPTDLFSFEAYSEKAFLLNYSRAPRQTEAAAHIVR
VDLTRNLGALVTDLWNESALYLDKTYNSEWQTKQAYEVVCGFVARVTSVA
MVGAPLCRNPVWNRIVVETTMASFGAAQAIKDKYSARWRWLAPWSESIQK
DLRRIRKESIELLKPLYEDRKAAVSRSDDVQGSSEMFRDTLYWLITSNQK
DRSLSGITESQLFLSLAAIHTTSATLNSFVYDWIAHPEYHGEILAEVKET
LAQVQLNGGKWTLQHVAMLRKLDSFMKESARINPIGFVSIQRYTLKPYTF
KDGFQLPAGVSFVFHSDGVHHDADNYPDPEKFDAYRHLHLRETVDPNRFH
FASVSDSALGFGAGNHACPGRFLSAIIMKFFLIQFMTAYEMKYEHGGIER
LPNHDNSNTTAPNRTVNLLACDSSKEYAKALENNEVPALILLG*
>CYP603C1 Aspergillus clavatus
51% to CYP603B1
ACLA_078710
MMITLFTLAVVSIGFFLWWLLTVQPAVTKRALKHIPELRFEDNDTPERYTQDSRSLLFRGYDKYLRHGIPFQMRHPIEEL
GPQVLLPMKYLDEVKYASTSLFSFPLFSEKVFLLNYSNAPRQTDAAAHVVRVDLTKNLGALANGMYQEAIEGLNQSLSAS
EEWNTLPAYDFLSSLTAQVTALALVGPELCRNREWIDISLQTTFAIFNAAFTIRSQYSPRWRWLARWQSDAPKRMRAMRA
RAVELLAPVYQDRLAAIKEHDFGAFADCLHWSLRGNGGETSLTRIAEQQLFLTVASMHTTSSTLTAVLFDLLIRPEYCAE
ITKEMQEALTECEGKWTLQEVAKMRKLDSFMKESQRVHPIGFITAQRMTVRPHTFKDGLHLPAGVIFQFPADAVHHDPAI
YPRPDQFAGYRFLHLRETVDANRYHFASVSDTMLGFGAGSHACPGRFFTSLAIKLILVVLLTQYEVKLADCDGSRPANGF
NDFNMGPSREATIMIRKRSGL*
>CYP604A1 Magnaporthe grisea MG02272.4 poor match AACU01000440 cont2.445
MIVETLHITKALVMDILDKASLPHLIFLLISAYWILCQFAPNRNPTLPGA
PIVGKRLWLEPTFLQRWRFVFHARDILSDGYAKYKDKPFVVRKLNGDVTI
MPMRYLTETRLLPESVLSFKFALSKFFLPEQMNLNWIKTSERDPNMLKMK
LTPEISRFIEMTRQEMEQTLPTTMPKPTSWTVVDVQSAIRTIIARMTTRA
FMGHPACDDPEWVKMSIDFTPQLLSTVFAVSPFPAWTHSILTRLLPSRYR
TLQRMRYCSELVAARIEARRGGKTPPDDCLLDYMLDHGGADDVYETGQRQ
CMLALASNHTTAAAAINFLFDLCAHPEYFSILRDEIASVTAAHGRPGSPG
VDVKTWLHALEKMDSFLTESLRHTPAILTIPQRQAMRDIVLQDGTLIPAG
ARIAFPSYWHTHEAKPTLRDPDVFDGLRYYKLRRGEGGDPMRYRSVQVDA
DHMMAFGYGSQACPGRHFATSQVKLLVARLLEEWDFAWPDGLEKPDIGYF
EENTLLDPGHKLKVRLRGAEPGHETH*
>CYP605A1 Magnaporthe grisea MG08387.4 poor match AACU01000342 cont2.1579
MMTPTELITHYRIVQHSFAPLRLSWWETNRVIAVQIWRDSSFFTRILIAF
IGLCLLSIFSRLTRPRSLRRLGIPGAVQPRFSTWSLDFKKVLEDSAKKYP
NSPFCLNAFGTEYAVLPSKCYDEVKRLPEHQASAFAFFREAFHGAWTGAG
VQTPELGRTIAVELTRGIPSLVHWRQMDCAEAFKMCIGEPSEWREIQLFE
AIQRIVISVNSSSFVGRELGTNQNWLRLIYNMPLQLGIPTVILGWTPFLL
QPLLKPFLFAPLRMTQRKIKSMLRPVLENDVQEYEASSDKKNLLSPKEQG
KVQLTGWLLSRYKGKLDFEVLLQDFITVLFESTPSTASTLFHVVCELAAD
PALQDMLRQELEEHTDNGSLPQTHLNELRKMDSVMRESARASPFSYSTNQ
KDPYPPVVLYRKLSIPTKLSMGPELPAGTNICVDAHHINTSPDLWDQPHT
FDGLRHYRARQQPQNENRYKFANLGSDAPSWGDGLQACPGRMFADNTIKI
ILTHLLLNYDVKLRPGESKPEKGAMPNGSIVPDVWAKVLFRSRASSAVNE
GKK*
>CYP605B1 Magnaporthe grisea MG08378.4 poor match AACU01000340 cont2.1577
MLSLLETKIIEPFMVVRQTLAPLRLSRWQIFKHMTRILIFSSNTRTIIFC
VLMSLVGYIVSRIIWGRQEKYPDHGLPIVKTNDYHFDNIVAEGKRLYPNQ
AFMGINKRYKFVIYPSSSWEELKRIPEQTASIMDFQHVCNSGEWSLVGGE
THELVKTITAELTRSLPARVPNRQQDAKMTFDTIIGHCPEEKGFNLLMTS
LEIIAKINACTFVGRELGANKSWVTAVVYSPLWVYFAVTLCNATPDILRP
LLRPLFFLPALRNYWNMQKLLKPKLDREMETFRQTDDKRKLLVPKSDQDL
PFTHFLLSRYTEAAATIKQLVIDYIQVSYTSTPTTASALFHALWELAQHP
EAAEVMRRELATVMIDGNLPKTHLQELKRMDSFLRESFRLHPITRFTLQR
YVKEPFQLSDGSRIPPGVMAVVDAQEINRSPEIWENPDEFDMDRFYRLRE
ISGNDNRYHFVTTSSNSPGWGDGTQACPGRFFATSTLKIVMAHIVMNYDV
SLRKVAPLKSQPLVNGSYSPDDSVEIFFKSRNVE*
>CYP605B2 Aspergillus clavatus
53% to CYP605B1
ACLA_078670 revised
MWSLQSNIIEPYQVLRQSLEPLKLSRWQMTKLIARSMVNEISP
MVNEISPRTLVLLAVTCSLLVLYFSTRERQPVMPRELPVVKAKSYHFEDIIVEGRKKYPDRPYLAVNNRHSFVVYPPSCF
DEIKRLPEHSASAKDFFHTMNAGDWTYVGHETTPLLKTIIADLTRVIPARVNKRQQDTRMAFESIVGYAPEWKEIGLLMT
TFEIVAKINACAFVGRELGTNNKWVKAVMQSPLVIHVAVLIMNACPALLRPLLAPLAFLPTKMNQWDMRRLLTPMLQEDM
AIFKETKDRSELLRPKQNGKIPLTAMLLSRYKQGEATIRQLIVDYILISFDSTPSTASALYHVICELAAHPEAADVLRQE
LDEVMVDGKLPQTHLQELKRMDSFLRESFRLHPVSLFSLQRVLAKPVKLSVGPTIPAGAIIAVDAAAINRSPSLWKDPDE
FDMNRFHDLRQVPGNENKFHLLNTGSDSPGWGDGTQACPGRFFANSTLKIAFAYILQNYDVKRKEGSSPPKMTPLANGTW
APDDKAAALFKSRN*
>CYP606A1 Magnaporthe grisea MG04349.4 poor match 58% to MG03104.4
AACU01001098 cont2.822
MLENVLTVEIAVLSAFATCYFLYQTLFKPGNLPSFAIAGAKEGDWFPYFQ
AKIRNTADGQNAVFSAYKQHREEPCFLPFFGTPRGTVVLPLNWIKSILSQ
PDHVLNLYDVGVEMLQLEYAFLDKRFNNPPLHINLISKDLTKNYGDLIPD
MMEDIKVAFTEQWGRSDEWTTVTVYDTVQKILGLPLRPLVAPLITLPHRL
SLRRFRKIVVPEIQKRLADSNRGDTKAQQNDFLQWAIQQAKEFEDPYFSR
PEVLASRALFANYISIHTSTFSFTDLVLDLAMLGPQVQEELRQEIVSVLA
SCDGKWSKKALAKMEKLDSLLRESARVNTFMSGSSNRFVTAPEGLALPNG
QTLPKDTPIIFFAAPVMLDETYYPDPYEFQPFRFAPKATDDGDGGDDETG
AQDGKRARTAFACTSPEYLAFGHGKHACPGRFFAAAELKLMAAHILLEYE
LEKIERPASKWYSIVRLPSMTYELKIRRRL*
>CYP606A2P Magnaporthe grisea MG03104.4
(version4) poor match 58% to MG04349.4
AACU01001602 cont2.617
MEKLDSTLRESARLNSFVTFGSNRLVTAPQGLTLPNGQTLPRGVGIMLQA
YPVLHDEGIYPDAATFKPFRFAEARRDESADYVQRARNAFATTSPDYLAF
GHGRHACPGRFFAATELKLLLAHMLLGYDIEPRQRPRNKWYGIGRVPDME
ATVRIRRRKRE*
>CYP606A3P Aspergillus terreus
53% to CYP606A2P, 50% to CYP606B1
possible first exon followed by a frameshift
(&) and deletion
of most of the P450 sequence
ATEG_00556.1
MIDSLVLDRPAVLFAGLAFVGIIFLRILFSSLLPNIPIVG &
RESQRLNSFVVTATNRMVVNPNG
VTTPSGVRIPKGTMVYAPSYPVMHDPDIYPDPESFKPFRLADKRTALGEEGQSYVQRARQAWTTTSPKYPAFGHGCHACL
GRFFASTLLKLMLAYILMNYDFQFLERRPENMWIGSNRTPPMKATIMIKRRVESEK*
>CYP606B1 Fusarium graminearum FG11282.1
AACM01000464 FGcontig1.464_scaffold9
MIQAATDLVSRPAIAVPLIIFLSYITYQLFIKPSNLPDLPIIGARKSDWF
PLFQARIRNSLNVKAVLNSSYAQYKNQATILPLLDGGNVILLPRSDTKFA
SEQPTNQLSMHESVQHDLQTDWTTMTPSLTHDPIHLDLVLTHLTKEVGNL
IPDLAEEIEHCVRQQWGTSSEWTE
VCIFEKAQLITSGVTNRAFVGVPLCRNDEMLKLGIAFAQ
DIPLSSMLLKPFPNFLKPLVAPIIALPNRIHNNKFER
ILKPEIQARLAKYDAQATESEKPPKSERNDYLQWLIEQAKDIGHPKNWKV
NALSERVLMMNFASIHTTTFAVTHALLDIAASSPDLIAELRDEIKSVLEQ
HNGKWNKRAVAKLEKLDSAIRESQRKNSIVSVAVSRTIVAEKGVTFPSGT
HVPKGHRIAVPGYSVFQDPEVYPEPKKYKALRFYNARQNEKDEYVKSARN
AWPTTSADFLAWGLGRNACPGRFFASSEIKLMIAYMLLNYDIEHLDERPH
NTWIMQNRIPPMKATLRIRRVSQP*
>CYP606B2 Fusarium oxysporum
76% to CYP606B1
FOXG_13357
MANPVLELLSRPAIAAPLILIVSYVIYQLFLKHSNLPDLPIIGAREGDWFPILQAKIRNSLDVKAALNSAYIQYRNQAAI
FPLIDGGNIIYLPRSDTKFASEQPTNMLSMHESAQQDLQTDYTTMDPSLTHDPIHLELVTTTLTKEVGNLIPDLAEEIEH
CVRKQLGSSTDWSEICIMESAQKMLSGITNRAFLGLPLCRNEEMLKLGIAFAQDIPLSSMMMKLFPSFVKPLVAPLITRS
NRIHTRDFEKILEPEIKARLEEYDSQDEHTKSDRNDYLQWLIEQAKEIGNPKNWQVSALAQRVLLLNFASIHTTTFAVTH
ALLDIASSSPDLISELRDEVESVLKLHDGKWNKRAVAQLEKLDSAIRESQRKNSIVSIGVSRTVVGEKGVTFPSGTHVPK
GLRIAVPGYSVLQDSEIYPEPKTYKPLRFYDARQNEADEYVKSARNALPTATQDFLAWGLGRNACPGRFFASNEIKMLLA
YILLNYDIEHMAERPRNTWIAQNRIPPTKATLRIRRISRS*
>CYP606B2P Fusarium verticillioides
90% to CYP606B2 Fusarium oxysporum = ortholog, frameshift
and 5 aa deletion
FVEG_12187
MANPVLEFLSRPAIAAPLILFVSYIIYQLFLKPSNLPDLPVIGARKGDWFPILQAKIRNS
LDVKAALNSAYIQYRNQAAIFPLIDGGNIIYLPRSDTKFASEQPTNMLS
&
QQDLQTDYTTMDPSLTHDPIHLELVTTTLTKEVGNLIPDLAEEIEHCVSKQLGKSTD
WSEICVMESAQKMLSGITNRAFLGLPLCRNEEM
LKLGVAFAQNIPLSSMLMKLFPSFIKPLVAPLVTRSNRIHTREFEKILEPEIKARLAEYDSQDEHTESDRNDYLQWLIEQ
AKEIGNPKNWQVSALAQRVLLLNFASIHTTTFAVTHALLDIAASSPDFILELRDEVDSVLRQHDGKWNKRAVAQLEKLDS
AIRESQRKNSIVSIGVSRTVIAEKGVTFPSGTHVPKGLRIAIPGYSVLQDSKIYPKPKTY
KPLRFYNTRQNEADKYIKSARNALPTATQDFLAWGLGRNACPGRFFASNKIKMLIACILL
KYDIEHLTKRPRNTWIAQNRIPPMKATLRIRKRIRS*
>CYP606C1 Aspergillus clavatus
43% to CYP606B1
ACLA_061240
MAIITKIVAGLICVYIVRKLLFPSVAHLPKGLPIIGAKDSDWFPFLQAAWRNALNLQGNLLEAYAKHKDQAAILPIAGPG
GQTFVLLPASETKLVTDQPSTVLSLREVIVQGLLYEYTISDNFIVSNPTHTKLITTTLTNQVPNLLPGLANETIRGFEQQ
WGTNTESFRDVTIWDSMGAIVSRATNYAFVGLPYCRDSALLDAGIGFARALPFSQLLLSFTWKPLRPLASFLFTLPCRYY
ENRFTQILIPEIEHRLHHSFNPPSSPCSGETSGEAEKKNDFLEWCIEQAKESGDPRMWQPRTLAGRILLMNLVSIHTSSL
TIVNVMLDLASSTPEVLEELRAEVKQVLDTCGGQWTKLALSKMEKLDSVLRESARLNTLVAVGLRRRVVAKEGFTTTSGV
HLPYGNFCAVHNLGVVHDPNVYEQPDTFKPFRFVGLRRDVNSNDPNKDHVQRARLTFPATGCDYLAFGNGRQACPGRFFA
ASELKLMLAYALMYYDLEMMDSRPPDRWIGILRIPSSNAQLRVRRRKGTVEPSMNNDNLV*
>CYP607A1 Magnaporthe grisea MG07247.4 poor match AACU01000236 cont2.1347
MGWAAHLVVLALMGATLLLARLVHATTTRIYRHKHICDKLDCVGGVSATS
STPTWIAALFRSISGLQDAAQEGYDRFVKSTTRGPRPFVLPTMWTGGPIV
VLPPSMLPLVNRSPSHETGVPGLLEQFQFRYLHADPDVWANTAIHFDVVR
RDMAQKNMAPLAATIAGEWAAAFRACWDEDPAAAGKTVGGVSAWDSGVRI
MARVAMRVLVGLTGCRDESFFELSQLYARAFIVDGVAINCLPPVLRPLLA
PVLALRVRYYQRRVVGALVPLVEQRLARAAVEEADKTNHEPGDVIRWLIA
RSAAEGSPEQMQPVKIARRVVALMSMFGFAIGWVFAHALLDIYGGPSRDD
VVAGLEDECDRVRRRHGGSIDTKEAVEALFRVDSAVRESMRLSDVSVHIL
PLDVVAGEGIDLGGGVRITPGCGLRAVFPAQMVHTDPDNYADPKTYDAFR
FSRPFEADVAQQDGGENRDERGKKRELMTTTTATFLPFGYGRRSCPGRWL
VAHMVKQALAHVVLNYHVEVTQRPGPRRALLNFMLPAEAARIAVNRKKNV
QN*
>CYP608A1 Magnaporthe grisea MG10356.4 poor match AACU01001708 cont2.1991
MFTPKPQRTLGTSLDGPHPPVVNIPAEVRRSYKVNDAYSKALDQHGPVIM
VPRHGRNEYVIDHRYASVLLTDTKRFNFDKAVFDLLHFGFIAVADNGVFV
NDIDQAVEGNVQPRMNAIIAKIFPVFRQYFDRMEDEVPKPAETKEYTTIS
DMFSRMQLAVAHAMVVMVVGEEHAGPELAGHFAAVAVAMARMTGMDESTD
EWTWFPKLWVLFNGLSAVFLTIVPRFFFTVAPLLWKTRGEHLANGLAARH
GIHVPVFDLLLVKHYHEKQGLWALLGFFRCLIIVIGLIFASIHQTVVGGM
WQLIKLTEKQDEYLAAIRAEFEAVVPPGELMTVPKLAQLRLLDSFIREVF
RTKGDCWGPVRETTQPVRVGPYVIPKGAMCIVLIGRAHQHPDNYGPDGKK
FDGTQWVEKGKPASQTSHDYLPFGHGRWACPGRHLAIHEIKIMLYFLFTK
FDIKLRANTYRVKNTINTTTVAPEATFLVRRRAEYNGTV*
>CYP608A2 Uncinocarpus reesii
68% to CYP608A1
UREG_04981.1
MAASDVRLDIQPPLDGPSPPIIHITREVRRSDKVNDAYSQALDEHGPVIIVPRHGRDEYVIDHRYAHE
ILTDTKNFTFEK
TAQRPLSG-TPPIVSLTVCVLLRPLPVLALERQIQQHGPVMGLRRDGRVEYIVSDELTFQ
AAFDLLHLGFIALFDNGMFVRDIDSLVEKNVQPRMNAIIDRIFPVFQSYFDRMADELPNPANDKTPVECYNIFSCLQKAI
GHAMVTMILGPSHSSSVTAGHFAAVAVAMANMTGMHENTHEWAWFPWLWVLLNGFKAVFFTIIPRFFFCIVPSLWKMRKQ
HLATGLAARHGEYVPLFDILLVKHYHEKTGFRALGGFAWCVILCVGLIFASIHQTVVAGSWILIKLAQKQDEYLPAIREE
WDTVAPANEPLSVKKLSQLTLLDSFIREVFRTKGDTWGPLRQTTRPVRIGPYVLPKNAMCIVLISRAHQHPDNYGSEGKV
FDGFQWQRKGRPAVQGGADFLTFGLGRWACPGRQLAIHEIKIMLYMLFSKFDIRVKDGSFRVLDTINTTSVPPEATLLLR
RRQ
>CYP608A3 Aspergillus terreus NIH2624
XM_001218190
75% to CYP608A2 Uncinocarpus reesii
ATEG_09569.1
MELQARHTYAALLHFPSLARRVQNPSAKDLDIDLQHYPQVIHFP
NTTGAFCIDRSVIDEDAEATTSPGPLNLTHPEAILSDRTASCVFLYIASRTFASPTPT
PAYPAMFTPLPQLTSETSPGASSPPVVHINREIRRSIKVNEAYSKALDKHGPVVIVPR
HGRNEYVIDHRYAHEVLTDTKNFTFEKAVFEMLHLGFLALCDNGAFVHDVDSLVEKNV
QPRMNAIIEQIFPIFTHYFDRMADGLPNPAVDKTAVEFPDMFHRIQLAVAHAMVVMIL
GQPHASSTVAGHFAAVAVAMANMTGMHENTHEWTRLPWLWVLVNGYSAVFLTIIPRFF
FRIVPTLWKARNEHLKNGLAAKHGEFVPLFDILLTKHYHGTTGLFALAGFFRCVIVSI
GVIFASIHQTVVAGLWILIKLTQKQDEYLPALREEWERVNPAGECLNVKKLTQLTLLD
SFIREVLRTKGDTWGPVRQTTQPVRVGPYVLPKDALCMVLISRVHQHPDNYGTEGTAF
NGLQWAEKGRPAVQGAPDFLTFGLGRWACPGRQLAIHEIKVILYMIFSKFDIKLKGDR
YRVTNTINTTSVAPEATFMLKRRDV
>CYP609A1 Magnaporthe grisea MG07210.4 poor match AACU01000230 cont2.1339
MTGEADNPNILHATVSSLSTFQEWRVTTIVVLLLSLFALWLRSMASRPPL
PPSAPELLKTWEWPIFGSWRFFLDRADFFTEAAAASKTGNFSFYIGKLHI
VGVSREESRRILFDSKGLDLAAGVAAFVQSSPSIEAVDGKPLGDDPGFNG
AFNRTMAHLLKGQNFGRNLKFMVSDVHEGLESAIEAAGGSGEGIMDTFED
VNLILYRMTMRTFGATEIASDPALLRKTLGLFEVTERSSSPTRLVIPWLP
TLNHLRRMGSGAMLYWHFSKIVNERKKTGKKVDDAFQYLIDKDEDMTGIL
RFTLSALFAGQINTGINAAWVLVYLALTPSWYSRVQQEVDAVVAKYRTSP
NQAPVDVIRSLNLEQWENELASVRLCLRETIRLHTTGSVFRRNISGQDVS
LGSSGEIVPKGSFAIYSVDDMHMNKEYYPEPERWDPARYEGGNDPPYMGW
GLGRHPCPGMRFAKLEVVIIVTLFVTMFDFEVVDDKGRKTTEVPERARNS
FTAVKPAVPVRLALKTRQ*
>CYP610A1 Magnaporthe grisea MG01865.4 29% to 533A1 poor match AACU01000128
cont2.354
MSLNSSSILESASLGSGLPLNKGTLILLLAGVAALLVGLDKLLTPSVSSS
EPWLLKPSIPLIGHIINLLRYENDFHHRLYKQTGRPALTLQMLWGKLYVI
LDHRLGSAAMRASEASFDEFGKDFGEQILALQPDTMRRVNEDPAWFPMFN
RVSAESLAPLRLRDVTSDAADALARVVCETGDGSPLTVPNLYYWARELIT
SATLEAMMGPHGIVTSKDRSLNEYLWAFEGGVASFVTHPLPRFTARKAWN
GRAKVFEAMARYFGGEFDRTESRGMVKARSAISRVTFEAAELPRIETGAI
FPMVTNSGPMGFWFLYFIYSNRDVLARVRAELQAATVLTPNDDDGTQTAS
FNLARVEYSCPFTSACFKEAVRLANNGVQNRRMVGDATLRDGEGRSYLFK
KGTDLQISTGIGHRSREIWGDDALEFRPDRFLRPLTREQKAAYQVWGGGA
HLCPGRHFVLQEVVSMAAVLVVGFDLELTGPLRWEDVKMGQGTMGNNSCK
PVNDAKGLQAKVSRRAGWEKTTWAFEA*
>CYP611A1 Magnaporthe grisea MG10355.4 poor match AACU01001708 cont2.1991
MSVPLHERGLLGALAVAKLSDATTRVKDLNGFTLAIAGSVLLIFILDRLL
VPSHDPREPPLASTNIPLIGHIIGFARNSFTYYSMLNEKLCKPIFTILMP
GRRIYVITKPELVVQVDKKHKYFSFGPVVRDFSRDTFGLGKEATEILAQN
MYGEHGSWGLCEEMVAGMREALKPGDDLDRMNRIMAEEVSRSLDETKPDP
GSEFRVIKLAEWVSHVVTLATTKSVYGTHNPFVRKDVRDAFWIFEDHVIS
LLVHPFPQYACKKAIKARQYVTDALAHYYINGHQKEGSALARARFDYSVR
NNVPVEDIARFELGGTIAILVNTLPSCYWMLLLIHLYPELHRELQKEVDA
ALLIDEEKSHITIDITSVKNNCPLLLSTFKESLRYRGMGTALRIVTKDIE
LGGYLLKKDSMVQIPLQVIHSDTGNWGNDPLSFDPYRFLK APGKKLPDDS
GYRSFGGGKHLCPGRFFATNEILAVISLFISRYVMRPKGGGDWILPTTKN
SNAARQILQPDFDMEVEVRNRPGFEKYTWKVELHKSDKVISVLTGDTRGA*
>CYP611A2 Uncinocarpus reesii
57% to CYP611A1 Magnaporthe grisea, missing N- and C-terms
UREG_04980.1
MENLNGFTLIVIGATALLVTLHYLLNPKRDPREPPLVPPGIPIFGHLLGF
MRNRFDYYNKLNDRVRQPIFTICMLGRKIYVVTKAELISRADRKHKSISYAPIVSEFCSITCGTSNEATKILNHNLLGEH
GNWGLCEEMVSGIRAALKPGKDLDNISLAMAQEVSCLLDAIKPDPGQGYSTIQLSAWVKQIVTVATTNSVYGPHNPYKSQ
EIKDAFWEFEGGLMLMLAAPFPSYTARKHILARDKVTKALEKYFAERHFDHGSKVAKARFDTSVRNKVALPDIGRFEIGG
TVAILTNTYPAVYWTLLLVYVAPGLLADLRAEIDAALIIDPLKNNITIDITVMKSRCPLLLSTLKESLRYRGMGVAVREV
VEDTELGGYLLKKGAMLQVPIQVVHSDQACWGEDAKSFNPRRFLKDDT
DDTGM
KEVPNDIGYRSFSGGKHLCPGRFFATNEILAIVALFVSRYEMRPANGSEWVLPTTFNSNA
AAQVASPDFELEMEVRNRVGFEKYSWNVDLKPSKTVVAVLARDRVE*
>CYP612A1 Magnaporthe grisea MG10862.4 P450 part poor match AACU01000368
cont2.2095
MTDGPRKGMRKQTSPCRHFFTPKDKAHSGGKSSTGLCRDG
NNGKSKPRIPYIGHVLGAATSHTAYAQRLSAAHPTKPVATLHLGATKCYA
VFHPALQHALMRSRAVKYDEYPPGAVPAGFGVDPRVMAVLSRPDLAARYM
HEAAGMLGGEPLRRMERRAFAHLQSRLNALPRTAATADSLYVWLRDAMSM
ATAEALFGEHNPYRTRAAARDPLSLFRDQWTFERSLGRLLLARGSAAARV
LAPAGCRARDRVHAALAGYYAAGEEAQGAAAVVQGRAALLREAGLSAAEF
APHEITAMHGATSNTIPTLFWTVANVYLCPELVAELRAELEAAVELAPLP
GGAADAKQLVRIRPAELESRCPLLADCVREALRLSSQWIGWRTTHADVEI
SAEQSPDGRPYLLKRGVQVIMPAGITHRAPSVWATATADPESSKDGGGGS
VEEFDPRRFAAQSKHKIKSTKGGLGYVPFGGGPYLCPGRNFANHEILGFV
AALVLGFDIVGLKRDKVKMRPARIYEVSAKPAKGGDGGRVQIQRRNNWEH
VQFEFVFAN*
>CYP613A1 Magnaporthe grisea MG07743.4 poor match
AACU01000945 cont2.1439
MSALIMLFLSYGLYLLAATVCVLSLVALAELVIPGYSPKVLRVALSKVLN
IILEHRFPIQTPDGLHSIPSCPYQWPNGQGDDGKFLSGIENSARWRAKHG
SVYRIWSGMHPEVVLTEPGQLSAVFKDSDKHTKAPANNSGAYMDRLLGKC
VGLISGQEWRRVRGVVEGPFGFHAASSPSSSKGIERIVARHFEELARTGR
LRNGLIHPAEDLKMLPFWVVCEALYGRLPDRLVRELNSMAPLREGLFRHV
MQGGLARFGWAAWLPTAANAEMDEFQRRWTAFNEAAYEFAKAQQQQPSNN
SSPHDKLPPIVDMVDKMRAGHITQEHLLQTLDESLYANLDVTTGSLSWNL
VFLAANRDVQVRLRAELQAASDQSPQSKEAYLRSDATLLHACVLESSRLK
PLAAFSVPQAAPSARTVEGYVVPAQTSFVVDSYAINIHSDTWAPDNAAYR
PERFLGKGGGGSELRYKFWRFGFGPRQCMGKYLADNIIRRTLAHVVLGFE
LGWADEGEDWSRARDMWITHPDFCIRCTKSTQERMTAETGAGPHTEV*
>CYP613B1 Aspergillus fumigatus Af293
GenEMBL
XP_750856.1 also AY838877
GliC in the
gliotoxin biosynthetic gene cluster
39% to 613A1
MAFTLTILVPCMVLALVAARPVLYWVLSVVIDAFLRWKYPLPHHAGSKPMPRARYTWPNGQGTEKFFNGR
SAARQWRQRWGPIYQIWSGWCPEIVLTTPTHAVQFFRNSHRHTKAVNNDSGWLFGEVLGVCVGLLSGTDW
KRVRQQVEDGFSRPTAARYTGDLVFLAREYLQNTLLASSEQSLENKGIIHVEPAKTLQFYPFLSVAQILF
GRLSPMQRTQLTTLAPLREELFKEVIRGGINRLSIAPWFKSRGVRLLNEFQTQWEQFVEDAYHAAVKRNQ
SPRPLVIGLWEAYQAGTISKRECLQTLDESLYANLDVTTHALSWNVLLLAENGEAQTELRQEVLSALQSE
ASESYERYIDRDDTFLAACILESARLRPILPFSNPESAPEDLYVDGYLIPAN
(0)
TNVIVDAQAINIDNPYWVNGTQYNPRRFFSLNKSDVRHNMWRFGFGPRQCLGKHIGERMLKAIVAEIIRQ
YVISISADSALKNDLQEDSWVGLPATRIQCVPVGREVEKN
>CYP613B1 Neosartorya fischeri
NRRL 181
GenEMBL
AAKE02000024.1, NFIA_055360
95% to 613B1
Aspergillus fumigatus, name changed from CYP613B2
MAYALTILVPCLVLALVAARPVLYWVLSVVVD (0)
AFLRWKYPLPHHAGSKPMPRARYT
WPNGQGTEKFFNGRSAAKQWRQQWGPIYQIWSGWSPEI (2)
VLTTPTHAVQFFRNSHRHTKAVNNDSGWLFGEVLGVCVGL
LSGSDWKRVRQQVEDGFSRPTAARYTADLVTLAREYLQSTLLTSSEQSVEKKGIIHVEPA
KTLQFYPFLSVAQILFGRLSPMQRTQLTTLAPLREELFKEVIRGGINRLSIAPWFGSRGV
RLLNEFQTQWERFVEDAYHTAVKRNQSPRPLVIGLWEAYQAGTISKRE
(0)
CLQTLDESLYANLDVTTHA
LSWNVLLLAENGEAQTELRQEVLSALQSEASESYERYIDRDDTFLAACVLESARLRPIL
(1)
PFSNPESAPEDLYVDGYLIPAN (0)
160249
TNVIVDAQAINIDNPFWVNGTQYNPRRFFSLNKSD (0)
VRHNMWRF
160428
GFGPRQCLG 160455
KHIGERMLKAIVAEIIRQYVVSISADSALEKNVLQEDSWVGLPATRIQCVPVGRE
VEKN*
>CYP613C1 Aspergillus oryzae
GenEMBL
BAE56604.1, AP007154.1
72% to
613C2, 51% to 613A1, 50% to 613D1, 39% to 613B2
MLWILVAVVVIVGISSPFTRRITIEILSTILD (0)
90386 RYLRSRFPIFSVDGSRTLPTCPYKWPNGQGDVAKFLQGIENRDLWEKEHGQ
IYRIWSGMKSEVVLTQPSHLQAVFRDSNKHSKAENNNSGYL
MSELLGQCVGLVSRERWRTLRAVTEIPFQ
HDKMPSYLELIQRHTRHHFDRLLASGDLRQERIHPAQDLKMLPFWVVAEIFYGECDAEMKTELQQLCVLR
EDLFKRMIQGGIVRWQWSKYLPTATNRALAEFQRRWRAFNQRAYDRACQQQRILPIVLMIEAAREGSTSV
EQIYQTIDEALFANLDVTTGGISWNLVFFAAHSDIQERVRQEVLSATDHDAYLLSSSTLLAACISESARL
KPLAAFTVPQSAPTDRIIGGYNIPAGTNLVVDTYALNIRNGFW GADSQCYRPDRFLEHRATELRYQYWRF
GFGPRQCMGRYVADLVIRTLLAHLVAHYELGWVEPDPGKNSTWQRDLESWITIPDLQLRCVQRRND
>CYP613C1 Aspergillus flavus
99% to CYP613C1 Aspergillus oryzae
AFL2G_07286
MDCFSLDGQMLWILVAVVVIVGISSPFTRRITIEILSTILDRYLRSRFPIFSVDGSRTLPTCPYKWPNGQGDVAKFLQGI
ENRDLWEKEHGQIYRIWSGMKSEVVLTQPSHLQAVFRDSNKHSKAENNNSGYLMSELLGQCVGLVSRERWRTLRAVTEIP
FQHDKMPSYLELIQRHTRHHFDRLLASGDLRQERIHPAQDLKMLPFWVVAEIFYGECDAEMKTELQQLCVLREDLFKRMI
QGGIVRWQWSKYLPTATNRALAEFQRRWRAFNQRAYDRACQQQRILPIVLMIEAVREGSTSVEQIYQTIDEALFANLDVT
TGGISWNLVFFAAHSDIQERVRQEVLSATDHDAYLLSSSTLLAACISESARLKPLAAFTVPQSAPTDRIIGGYNIPAGTN
LVVDTYALNIRNGFWDADSQCYRPDRFLEHRATELRYQYWRF
GFGPRQCMGRYVADLVIRTLLAHLVAHYELGWVEPDPGKNSTWQRDLESWITIPDLQLRCVQRRND
>CYP613C2 Aspergillus clavatus NRRL 1
GenEMBL
AAKD02000041.1
note: this
sequence is upstream of the pseudogene CYP-un3
72% to
613C1, 49% to 613A1
ACLA_066860
MPWIILALPVLVLVTLLPRKVTNSIFSAIID (0)
24668 KYLRWRYPIRSIDGTHTLPTCPYQWPNGQGDVGKFLQGIENRDAWEKEHG
KIYRIWSGMKPEV (2)
VLTQPHHVQSVFRDSNKHSKAENNNSGYLMSELLGQCVGLISQEPWRHLRAVAEVPFQHD
KAPAYVQLVLRHIRQHFSSLHVHGDLQQGRIHPAQDLKMLPFWIVAEIFYGEIDIAMREE
LQQLCLIREQLFRRMIQGGLVRWRWSRYVPSATNRELTDFKSRFRRFNQQAYQHACNQNK
WSLPIVSMTEAAQSGKVSLEQIYQTIDEALFANLDVTTGGISWNLVFLAAHPEIQNRVRD
EAQTATACEAYLLSSSTLLAACVLESARLKPLAAFTVAQSAPTDRTVEGYCIPAGTNIVV
DTYALNIHNEFWGTDSQSYRPDRFLKHRATELRYQYWRFGFGPCQCMGRYVADLVIRALL
AHLVENYTMGILDGDEDKWKRDSESWITLPDMQLKCEPRDVPMTKL*
23208
>CYP613C3 Aspergillus niger
fgenesh1_pg.C_scaffold_11000488|Aspni1
53% to CYP613C1
MDTTILLAGQAVLIVVILVAVKFRTPITNRINRLISAILRWPDGQGDGAKFLQGQSNSERWERQFGAIYRLWSGMNPEVV
LTRPEHIQAVFKDSHTHLKAKNNNSGYLLGELLGQCVGLVSQDQWQRVRAIMEKPFHRNASTTYLPLVKRRTEQFFQELW
DTRDLSRGLLDPADDLKLLPFLVVAEVVYGRLAPDVEAELRRLAPQRENLMKHVIKGGLTRFAWSRFLPTQANRELAAFQ
QRWLAFNELAHRRAVEQKLNAPIIDFFAARDAGQISTQELLHTLDEMLYANLDVTIGGVSWNVVFLAAYRDIAKRLREEV
EQQRAISVDGEVDAYLLDNSTLLAACVEESARLRPLAAFSVPQAIPTARTVGGYHFPAGTNFVVDSYALNIRNPYWGEER
HLYQPDRFLARSLTQARYHFWRFGFGPRQCMGKFVASVVIRAILVHLVEGYDLRMVKPEAMEEWGRNKEIWINHPDMKVR
S*
>CYP613D1 Aspergillus oryzae
GenEMBL
BAE58578.1 AP007155.1
50% TO
613C1, 47% to 613A1, 48% to 613C2
MGFSIQHGLTKPEILYPFLFGIFAVASLCIATLLFPASFSAASRVISWVLS (0)
4127460
IYLELKNPIRHTETGRNIPGPSYVWPNGQGDIEK YVQGRSRSEQWQRKYGNVYRIWAGMTPEV 4127272
4127213
VLTRPEQLHAVFKDSDKHTKATNSDSGYF
MSRILGQCLGLMAGPRWKLLKGTAAPPFMHPTAVRSIGRIQEHVRAHFHDLETNGNLREGRIHPVQDLKM
LPFFIVAEANYGSLTPAMKSELDSLAPARENLMKFVLFGGLARFNISRFFPTEANRQLRRFRSQWRAFNR
AAYERAREKHPSAMVVQMYDAVHKGVLTEEQVAQTMDETLYANLDVTTGGLSWNLVFLAANPACQARLHE
EISALTPAEEEGYISRNGTYLAACVLESSRLRPALPFTIPQSAPTERVVDGYRIPAGTNYVVDTWGLNVR
DEFWAPDNSTYRPERFLNSSNTDLRYHFWRFGFGPRQCIGRYTADVVIRAILLHLVKHYELQMLEEGDFT
QDPECWITHPDLQVKPN
>CYP613D1 Aspergillus flavus
99% to CYP613D1 Aspergillus oryzae
AFL2G_01551
MGFFIQHGLTKPEILYPFLFGIFAVASLCIATLLFPASFSAASRVISWVLSIYLEVKNPIRHTETGRNIPGPSYVWPNGQ
GDIEKYVQGRSRSEQWQRKYGNVYRIWAGMTPEV
VLTRPEQLHAIFKDSDKHTKATNSDSGYFMSRILGQCLGLMAGPRWKLLKGIAAPPFMHPTAVRSIGRIQEHVRA
HFHDLETNGNLREGRIHPVQDLKMLPFFIVAEANYGSLTPAMKSELDSLAPARENLMKFVLFGGLARFNISRFFPTEANR
QLRRFRSQWRAFNRAAYERAREKHPSAMVVQMYDAVHKGVLTEEQVAQTMDETLYANLDVTTGGLSWNLVFLAANPACQA
RLHEEISALTPAEEEGYISRNGTYLAACVLESSRLRPALPFTIPQSAPTERVVDGYRIPAGTNYVVDTWGLNVRDEFWAP
DNSTYRPERFLNSSNTDLRYHFWRFGFGPRQCIGRYTADVVIRAILLHLVKHYELQMLEEGDFTQDPECWITHPDLQVKCVRRT*
>CYP613E1 Mgr057 Mycosphaerella graminicola
48% to 613C2
MQGVLRRKHRVASLDGTREIPTCTYQWPDGQGDRAKFLEGGTNSVRWEEAHGPIYRLWSGMRPEIVLTQPHQVQRVFKDS
ANHIKAPANNSGCYMDKLLGSCLGLISGKSWRALRDVVEPPFGHKAMGSLTREIERQVGEHIRKLSTTGRPAHGRLHPTE
DLKMLPFWILCRAIYGPLPLHLVEQIEAMIPLREAAFRRVISGGIHRFCFFRFVSTHARDQLVRLQKDWRAFNQSALEYA
RIHAEKAPIIAMWDAVAEGKVSEVQVLQTLDEMLFANLDVTIGGLSWNFVFLAASPADQSRLRAEILSVNKEGCLEQYVQ
SSHSHLGRCVLESSRLRPLAAFSVPQSSRSTVVLDGFVIPEGTDFIVDTHALNIRGKLWSPDNLEFRPERFSQLKPTDLR
YAFWRFGFGPRQCLGRHIADLIIRHTVVQIVQRFELAILDDKAWERDKAMWISCPDFELSC
>CYP613F1 Neosartorya fischeri
42% to CYP613C2
NFIA_074290
Note: this seq does not have an ortholog in A.
fumigatus
MIKYMPGGMPLLLQLAVLSIVAFVGYAFRPNSWSNRVVSYVINKILLWWYPIYSIDGRSSIPTCPYRFPDGGGKIKFLEG
ETISRKWAKQYGPIYRIWVGLTPEIIVTRPEDIKTAFKDSGNHRKAPNLNGGWVMGELVGDGVGLISQADWKRVHAVVSP
PFAQRPITYVPLVQSRIDRHFAELSQRHSQDRRTMRLRPAEDLKLLPFWVISDLLYGELPQPMVEELLRITELRTDVFQY
AFKGGLSLFSISRWFSPALRNKLHFFHTRWAEFNRQAYHRAKASDAAAACAIVPLSTAVEEGRISRTELLHTLDEALFAN
IDVTIGSFSWIPPFLAAHADVQRELRDEIKQARSQATATPTQDAWVKYLASNTTLLASCINESARLKPVTNYTYAQSLPT
GREVGGYLIPVGTYVVVDTNALNLRDPGWGSDRGEFRPRRFLEKPRGEFRYRLWRFGFGPRQCIAQALADTVLKVLVAYM
VENYQVKVPEKPTGGESEERKRGDAWFKVAEQQILLEPL*
>CYP613G1 Aspergillus terreus
50% to CYP613C2
ATEG_03474.1 gene mosdel too long at N-term
revised
MYPLESVRHLVVEQSQLCYILFGAVLAYAGWRWVLRLDILNEAITD
LMSNLLNYYLTRRYPIHHSETGQQIPGRSYRWPNGQGDQGKFLDGIENRAQWAKEHGRIYRIWAGTTPEVVLQTPEHIKL
VFRDSDRHSKAVNNDSGYLMGQVLGQCLGLISGGDWRRVREVCEAAFTHSKAINYLDLIHSRVGDYLQKCTALQRGTLNP
ADDFKFLPFLVVGDILYGHMTQEMEDELRQMAPLRERLFQFVIRGGLARYTWSQYLPTEANHALREFRSRWVAFNQAAYC
RARERGATATPVYQLFTAVSDGMITAANAYQTLDEMLFANLDVTLGGLSWNPVFLAANPAVQEELYENITAAQEAEGPAM
PMYLQDSSTYLAACILESSRLKPLAAFSVPQAAPTARVLDGYVIAGGTNYIVDAYALNVEHEFWGPDRHEYRPGRFLGVK
GADLRYHMWRFGFGPRQCLGKYVADLILRVFLVHLVRNWRLGFEDGQIADSREWKRDLDAWITHPTIELTCTPRGARA
>CYP614A1 Fusarium graminearum FG02113.1
AACM01000111 FGcontig1.111_scaffold1
MITPLHAIGFILLGYSGLCTVQLLWNYRKAKAIGLPVLITPIDPSNVPYL
LCSSWLEPLLRKILPFGLGNFVEYNSRDWNYSQIHGLQERIGDTFIIVSP
KQIRVFTGNAKASDDLCRRRKDFVKAVALYKPLEIFGRNVVTTEGDDWVR
HRRITTPPFNERNSALVWDESKRQATDMLNMWASNPKGVVNPQSDTMVLA
LHVLTAAGFGRSYKFGSGLESELENHSLSYRDALSLILGNLFTAVFTATL
NLPTWMLPSKFKKVQDAIINFRQYMAEMVAEEREAMNAGAEEQDNLMSIL
VRASENENKQGKGARHLTDTEIYGNLFSYNLAGHETTSNTLAYATVLLAA
NPEWQKWAAEEVDQVTAGVDLKDLDYETYYPQLKRVLAIMHETLRLFGAA
RAVPKTTLVDQTLKVNGTSYTIPKNTFIGVNLAGLHVSSASWGDNALEWL
PSRWITRDETEGEKMTVMPTGAFLPWAAGPRVCPGKKFSQVEFVAVLASL
LKEYTVEPDADGEGDLKTAASMALMEEAKQSSFNFLLKVKHPEKIKLRQG
PVIMSLHVHNWYLLSLSFLFIPVVTYAVSKLAGRLNTLKEVRLLKDLLVF
FLLQNSYIGQLTAEVQMNKHHEHEADGGKTQESISKTKGASWNTTQSMDM
NTIFTLPGP*
>CYP614A2 Fusarium oxysporum
91% to CYP614A1
FOXG_04460
MISPLYAIGGLLLAYIGLSTLQLLYNYKKAKSIGLPVLITPIDPSNVPYLLCSSFLEPLLRKILPFGLGNFVEYNSRDWN
YEQIHDLQERIGDTFIIVSPKQIRVFTGNAKASDDLCRRRRDFVKAVALYKPLEIFGRNVVTTEGDDWVRHRRITTPPFN
ERNSALVWDESKRQATDMLKMWASNPKGVVNPQSDTMVLALHVLTAAGFGRSYTFGSGLESALENHSLTYRDSLSLILGN
LFTAVFTATLNLPTWMLPSKFKQVQDAVVNFRQYMAEMVAEEREAMDAGAEEQDNLMSILVRASENQNKEGKGTRHLTDS
EIYGNLFSYNLAGHETTSNTLAYATILLAANPEWQKWAAEEVDQITAGVDLKDLDYETYYPQLKRVLAIMHETLRLFGAA
RAVPKTTLVDQTLKVNGTSYTIPKNTFVGVNLAGLHTSSASWGDNALQWLPSRWITTDETGEKLAPTPTGAFLPWAAGPR
VCPGKKFSQVEFVAVMACLLKEYTVEPDAEGDLKEAASRALMEEAKQSSFNFLLKVKHPEKIKLRCVRRV*
>CYP614A2 Fusarium verticillioides
94% to CYP614A2 Fusarium oxysporum
FVEG_07580
MISPVYAFGGLLLAYVGLSTLQLLYNYKKARAIGLPVLITPIDPSNVPYLL
CSSFLEPLLRKILPFGLGNFVEYNSRDWNYEQIHDLQERIGDTFIIVSP
KQIRVFTGNAKASDDLCRRRRDFVKAVALYKPLEIFGRNVVTTEGDDWV
RHRRITTPPFNERNSALVWDESKRQATDMLKMWASNPKGVVNPQSDTMVLA
LHVLTAAGFGRSYTFGSGLESTLENHSLTYRDSLSLILGNLFTAVFTATLN
LPTWMLPPKFKQVQDAVVNFRQYMAKMVAEEREAMDTGAEEQDNLMSIL
VRASENQNKEGKGTRHLTDSEIYGNLFSYNLAGHETTSNTLAYATILLAA
NPEWQKWAAEEVDQVTAEIDLKDLDYETYYPRLKRVLAIMHETLRLFGAA
RAVPKTTLVDQTLKVNGTSYTIPKNTFVGVNLAGLHTSTASWGNNALQWL
PSRWITADEKLATMPAGSFLPWAAGPRVCPGKKFSQVEFVAVMACLLKDY
TVEPGEGDQAAARALMEEAKQSSFNFLLKVKHPEKIRLRCVRRV*
>CYP615A1 Fusarium graminearum FG08183.1
AACM01000329 FGcontig1.329_scaffold5
MAYPIILIGVIGLPIIILLRWLLTYTRTVLKVRRNGHPAIHSGVMIFESV
VRSWYPRIPFLVPMEKFTLKDPFKKFADARSDMIVITEASSPNGIAYLFG
SPKIFREIGRNGDIFLKPLEKIRYRMLNTFGLQLASTQNGTQHERHKRVV
KAVFNNELMENGWQNMRNMWRSLLREEGVYPTAANSDAAPIVRDMKSTML
KVTLGAIGASWFDIDIPWNPAKETQRQNDELMPFAETLKVVWDSPFVQTI
LPLWFMEWSPSLHLRRAAWAQRSLVTHIKNAQAETRRRIEDSKDKAQVQG
RMRKYRNLIDALVDSQNDVEMAEKAEKGYLAPNVGLSDKEVQGNIFSFMV
TGHETSSHTLTWVLSLLAKNTDWQERLYAEVSKVNTLPLNEAESANGAKP
LKCLGYEEMANLPLILAATVETLRMRDLAMQMTRVASRNTTLSYTTWDGD
ATNPSEAKVQQHTITIPAGTRVHLDTAAFGVNPFKWEDPETYNPERHLRE
TEDMNGNKKVTISYEDFIGYSSGSRQCIGKRFAEVTMVCFLAHMILNYRW
EVVPEAGETQEQAKVRASTGSEQFMLTPPAYDLRFIRR*
>CYP615A2 Fusarium oxysporum
88% to CYP615A1
FOXG_12223
MASPLLLIGAIGLPIIILLQWLVTYARTVLKVRRNGHPAIHSGIMIFESVIRSWYPRVPVLVPMEKFTLKDPFKKFANAR
SDMIVITEASSPNGVAYLFGSPKIFREIGRNGDIFLKPLEKIRYRMLNTFGLQLASTQNGAQHERHKRVVKAVFNNELME
NGWHNMCNMWRALLREEGVYPAAANSETAPIVRDMKSTMLKVTLGAIGASWFDIDIPWDPAEESQRNTKSDLMPFAETLK
VVWDSPFVQTMLPLWFLEWSPSLYLRRAGWAQRSLVAHIKNAQAETRQRIEDMKDNTEVQGRPRKYRNLIDALVDSQNDV
EKAEKAEKGYVAPNVGLSDKEVQGNIFSFMVTGHETSSHTLTWVLSLLARNTDWQEKLYAEVSKVDTLPLDEDESVGDAK
PLKYFGYEEMANFPLVLAATIESLRMRDLAMQMTRVASRDTTLSYTTWDGDAANPSEAKVHQHTVAIPKGTRVHLDTAAF
GVNPFKWEDPQTYNPTRHLRETEDVNGNKKVTVSYEDFIGYSSGSRQCIGKRFAEVTMVCFLAHMIMNFRWEVVPEPGET
QEQAKVRASTGSEQFMLTPPAYDLRFIRR*
>CYP616A1 Fusarium graminearum FG09671.1
AACM01000401 FGcontig1.401_scaffold6
MLVPFLSAVATLMPSLLMGIFILCLLGFSAITFNIFVYPFYLSPLRHLPG
PTDNAFFFGQAAKFLQVPWFPELFCQWSRDHPGAPFIRYLNFANSETLFV
NTIGAYKQVLQTKSAFFVKPAFARQFAHEIIGDGLPFVEGNLHKLRRAAI
SQPFSAPRLREFYPTVQGKAEQLVRVLSQRHDKNGNVEIETNVWKTVLDV
IGLETFGLDLNHLESNESPLFETFTTMMQPSALGHIVNYLNSLVPIRQFI
PIAECVEFSKSCTMVREFILCLINIRRNLGEKGFINNQDALQCLLEHNDA
DWNDESLVEYVLNLLVLGHDTTACSITWAIHELSRRPDCQQRLRDEIKIL
DDTCPMISFNDIDKLPYLHNFVREVLRLYCAVAMAPRQATEDVEIEGVII
PKGTVVQLSPAVMNTHPSVWGSDAQVFNPDRWNGLKGDAASAYAFETFHN
GPRMCIGKQLSVMEMKVMLVEIVHKFEIHKPFGDEFKEVAVAGPTFTLRP
KEKLVVRLVELLYDARYTIQHTPMTYPFPF*
>CYP616A2 Nectria haematococca
e_gw1.5.226.1
Necha1/scaffold_5:198240-199706
72% to 616A1, no introns
This gene model seems correct
MLGFAAFNIFVYPFYVSPLRRLPGPTDNTFFLGQTTKFLQVAWFPELFCEWSRAYPEAPFIRYLNLANSE
TLFANTIEAYKEILQTKSGMFVKPDFARKFVHEIVGDGLPFIEGKLHRQRRAAISRPLSTPRLKAFFPIV
RNKAEQLAQVLSEQRNSVGNVQVETNIWKAVLDVIGLETFGLDLNHLEGDQSPLFKAFTNMMQPSLIGHI
VNYLNSLAPIRQFLPIEECRELVQSCTRAREFIIGMIAIRRRTLEKGHVEETQEPDALQCLLDYSDPSWD
DNSIVEYILNLLVLGHDTTACSITWALHELSRRPECQQRLRSEIISFDKTCPSPDFGDIDKLPYLHNFVR
EVLRLYCAVAMAPRQATQDVKIAGVMLPKGTVVQLSPAVMNTNPSIWGPTAQTFDPDRWDNLEETAASAY
AFETFHNGPRMCIGKQLSMLEMKVILAEMVRRFRIEKPLGFEERPVEVAAPTFTLRPKEKLVLRLVEL*
>CYP616A3 Fusarium oxysporum
74% to CYP616A1
FOXG_08398
MASVLPLMLSLSMGLVVLGMLVMGMIAFNVFVYPFYVSPLRYLPGPKDNAFFLGQTAKFLRVPWFPELFCKWSREFPDAP
IIRYLNFANGETLFVNSIEAYKQVLQTKSSYFVKPAFAKQFAHELIGDGLPFVEGKLHKVRRAAISQPFSAARLRAFSPV
VQQKAEQLIDVLTQQRNEHGNVEIESNIWKAALDVIGLETLGLDLNHLGSDESPLFDTFTTMMQPSTFGHVVNYLNSLIP
IRQYVPLKECIEFSQSCTRVREFIVGLMTIRRNQCEQGLVNEKHRDALQCLLEHSDPDWNDKNVVEY
(0)
VLNLLILGHDTTACSITWAVHELSRRPDCQQLLRDEITSMDNTCGMSSFSDIDKLP
YLHSFVREVLRLYLAMAPRQATDDVEIDGIMIPKGTVIQLSPAVMNTHPLVWGPDAQEFNPDRWSDLTGDATSAYAFETF
HNGPRMCIGKQLSLLEMKTMLVEMVRKFKIEKPLGNEEKQVDVAGPAFTLRPKENLVVRLVEM*
>CYP616A3 Fusarium verticillioides
90% to CYP616A3 Fusarium oxysporum = ortholog, possible gc
boundary at VEY
FVEG_06280
MTSLLSLVPYLSMGLVILGMLVMGIIAFNVFVYPFYVSPLRHLPGPKDNAFFLGQTAKF
LQVPWFPELLCKWSREFPNAPIIRYLNFANGETLFVNSIEA
YKQVLQTKSSYFVKPAFAKQFAHEFIGDGLPFVEGKLHKLRRAAISQPFSAARL
RAFSPVVQQKAEQLIDVLTQHRNENGNVEIESNIWKAVLDVIGLET
FGLDLNHLESDESPLFDTFTTMMQPSTFGHVINYLNSLIPIRQYVPMK
ACIEFSQSCARVREFIVGLMTIRRNQYEQGLVSPEKNRDALQCLLEHSDPDWNDKSVVEY
(0)
VLNLLILGHDTTACSITWAVHELSRRPDCQQRLRDE
IAGMDSTCDMPGFSDIDKLPYLHNLVREVLRLYLAMAPRQATDDVE
IDGIMIPKGAVIQLSPAVMNMHPLVWGQDAQEFNPDRWNDLAGDATSAYAFETF
HNGPRMCIGKQLSFMEMKIMLVEMVRKFKIEKPLGSQDKQVEVAGPAFTLRPKENLVVRLVAM*
>CYP617A1 Fusarium graminearum FG01048.1
AACM01000052 FGcontig1.52_scaffold1
MGLPWEIITATSAISTLTLAWTHDDWSKSQLLGRFPVFWIAGLAVWIVWA
VWVYPLLVSPLRHLPGPSGNHWLMGQSKKIMAEPSGVPMRQWASEIPNDG
LLCYRGFFNQERVMVSSPKALAEVLVTNSYAFPKPSHFRWSIGRILGVGV
LLAEGDEHKMQRRSLTPAFAFRHIKNLYPVFWRKAREVTRTMMAEFGQQE
ETQVEISGWASRATLDIIGLAGMGRDFGAIQNPNNTLAQTYSKIFKPSRQ
AQILAFVGMIIPMEFITKLPFRRNEDIAKAASDIRAICRDLIQEKKAKMA
NKEQADVDILSVALESGGFTDENLVDQLMTFLAAGHETTASAMTWAIYMM
ARHSDIQTRLREEIREHLPSVDSDVDITSLDIDRMPYLNAVCSEVLRYYA
PVPLTMRDAAYDTTILGQTIRKGTRIVIVPWATHFDHDLWGPDADQFNPD
RWLSAGGENKIGADRKAASGGANSNYAFLTFLHGPRSCIGSSFAKAEFAC
LLAAWIGRFEFSLANPEEMDEKNVEIRGGVTARPAKGMHVKVKVIGGY*
>CYP617A2 Nectria haematococca
e_gw1.2.235.1
Necha1/scaffold_2:1188558-1190265
73% to 617A1
This gene model seems correct
MGLPWENITGGAATVTLALSWVQNDWSRLLLLKHFTGLWTVGFVFWVVWAIWIYPLLVSPLRHLPEPSNN
HWLLGQAKRIFAEPSGIPMREW (2)
VSEIPNDGIIRYRGLLNQERILVCSAKALAEVLVTNNYAFEKPSYLQQ
SIGRILGIGVLFAEGDEHRVQRRNLTPAFAFRHIKDMYPIFWRKAKEVTQAMTTEVGGRDEVELEVSSWA
SRATLDIIGVAGMGRDFGAIQDPESVLARTYRKIIKPSRAAQILGLISIFIPLQIVTKLPFRRNQTINAA
ADEIRAVCRDLIQEKKAKLANKEQPDIDILSVAIESGGFTDENLVDQLMTFLAAGHETTASAMTWAVYML
SRYPEVQSRLREEVRERLPSVDSDSDITSLDIDRMPYLTAVCSEVLRYYSPVPLTMRDAAHDTTILGHPV
RKGTRIVIVPWATHFDQHLWGPDADRFDPERWL
PSGPEGGAADRNAASGGATSNYAFLP
FLHGPRSCIGQSFAKAEFAALLAAWVGRFEFALANPEEADESKVEIRGGVTARPSKGMHVKVKVMGGF*
>CYP617A3 Fusarium oxysporum
85% to CYP617A1
FOXG_00341 revised
MGLPWERITATAAIGTLSLAWAQNNWARLQLLGHFTELWIASLAIWGVWTVWIYPLFVSP
LRHLPGPSGNHWFMGQAKKIMAEPSGVPMREW (2)
ASTIPNDGLLCYRGFFNQERVMVCSPKALAEVLSTNSYAFPKPSHFRWSIGRILGIGILLAEGEEHK
MQRRSLTPAFAFRHIKNLYPVFWSKAREVTRTMMAEFGGKEEVHVEISSWASRATLDIIGLAGMGRDFGAIQDPQNTLAQ
TYKQIFKPSRQAQVLAFIGMIIPMQFITKLPFRRNEDIAKAATDIRAVCRDLIREKKAKIANKEQADVDILSVALESGGF
TDENLVDQLMTFLAAGHETTASAMTWAIYMLSKHSDIQSRLRDEVREHLPSVDSDVDITSLDIDRMPYLNAVCSEVLRYY
APVPLTMRDAAYDTTILGHSIPRGTRVVIVPWATHFDTELWGQDAGQFKPERWLPSGGESGSADRKAASGGASSNYAFLT
FLHGPRSCIGSSFAKAEFACLLAAWIGRFEFTLANPEEMDEKKVEIRGGITARPAKGMHVNIKTVSGY*
>CYP617A3 Fusarium verticillioides
96% to CYP617A3 Fusarium oxysporum = ortholog
FVEG_01179
MGLPWERITATAAIGTLSLAWAQNNWVRLQLLGRFTELWIAGLAICGVWTVWIYPLFVSP
LRHLPGPSGNHWFMGQAQ KIMAEPSGVPMREW (2)
ASKIPNDGLLCYRGFFNQERVMVCSPKALAEVLSTNSYAFPKPSHFRWSIGRILGIGILLAEGEE
HKMQRRSLTPAFAFRHIKNLYPVFWSKAREVTRTMMAEFGGEGEGEVHVEISSWA
SRATLDIIGLAGMGRDFGAIQDPQNTLAQTYKQIFKPSRQAQ
VLAFI
GMIIPMQFITKLPFRRNEDIAKAATDIRAVCRDLIREKKAKIANKEQADVD
ILSVALESGGFTDENLVDQLMTFLA
AGHETTASAMTWAIYMLSKHSNIQ
SKLRDEVREYLPSADSDVDITSLDIDRMPYLNAVCSEVLRYYAPVPLTMR
DAAYDTTILGHSIPRGTRVVIVPWATHFDTELWGQDAGQFKPERWLPSGG
ESGSADRKAASGGASSNYAFLTFLHGPRSCIGSSFARAEFACLLAAWIGR
FEFTLANPEEMDEKKVEIRGGITARPAKGMHVKIKTVSSY*
>CYP617B1 Fusarium graminearum FG02118.1
AACM01000111 FGcontig1.111_scaffold1
MAPIAVFLSYYRPWAAIAIVVAVYYQIIVDQNYSVKNAPFYLGKYLLGFL
SIWAVYTVFLYPALLSPLRHLPQPKPGSFINGHWAESVREPAGLPFRHWM
RTIENNGLIRYKHLFNQERILVTSPEGLKEVLGQNSYDYVKPHLLRAMVG
KILGYGLLLSEGNVHKMQRKNLMPAFSFRHIKELYPVFWSKAQELVHGIE
KEMSEAPGSQIDIADWASRASLDIIGSAGMGHEFKSLSDPSIEDTMKMYG
SMVKQSGGAKLLTVLQLVLPSMITDYLPFQRNMGVLAASKAARDTSQRLI
NAKKVQMAAKEKLSPDIISTALESGHFTDEGLVDTMMTFLAAGHETSAAA
LTWTIFLLAKNHGIQDRLREEIRQNVDGLADDVDSKKLDGLSYLHAVCQE
SLRLYAPIPFTVRDSLRDTTILGTFVPKGTMIILCPWAINRAHESWGADA
DDFYPERWMVPGQANSGGAKNNYANLTFLHGPRSCIGQKFSLAELMALTC
ALVGRYRFDIDKDYEVKDLTDGIVAKPREGLKVSVEEIQGW*
>CYP617B2 Fusarium oxysporum
87% to 617B1
FOXG_04464
MARIAVFLSYYRPWALCALAFAIYVQIIRDKNYSIRHAPFYMGKYLLAFLSVWAFYLVFLYHRFFSPLRYLPQPKIAGFI
NGHWAESVSQPAGLPFRHWSRTIENNGLIRYK (2)
HLFNQERLVVTSPEGLKEVLGQNSYDYVKPHLLRAMVGKILGYGLLLS
EGDVHK (0)
MQRKNLMPAFSFRHIKELYPVFWSKAQELVHGIEKELKEESTSEIDIVDWASRASMDIIGSAGMGHEFKSLADP
SIEDTMKMYGSMVKQSRGAKLLTVLQLVLPSIITDYLPFQRNMGVLAASKAARETSQRLINAKKVQMAAKEKLSPDIIST
ALESGHFTDEGLVDTMMTFLAAGHETSAAALTWTIFLLAKNHDIQNRLREEIRQNVDGLTDDVDAKKLDSLSYLHAVCQE
SLRLYAPIPFTVRDALKDTQILGTFIPKGTMVILCPWAINRAHELWGPDADDFNPERWMAPGQANSGGSKNNYAFLTFLH
GPRGCIGQKFSLAELMALTCALVGRYKFDIDKDYEVRDITDGIVAKPSKGLKVTVEEVQGW*
>CYP617B2 Fusarium verticillioides
95% to CYP617B2 Fusarium oxysporum = ortholog
FVEG_07585
MPRIAVFLSYYRPWAVCALAFAIYTQILHDKDYSIRHAPFYMGKYLLAFLSVWAFYLVFLYHWFFSPLRHLPQPK
(0)
GASFLNGHWAESVSQPAGLPFRHWSRTIENNGLIRYK (2)
HLFNQERLVVTSPEGLKEVLGQNSYDYVKPHLLRAMVGKILGYGLLLSEGDVHK
(0)
LQRKNLMPAFSFRHIKELYPVFWSKAQELVHGIGKELKEESTSEIDIVDWASRAS
MDIIGSAGMGHEFKSLADPSIEDTMKMYGSMVKQSRGAKLLTVLQLVLPSI
ITDYLPFQRNMGVLAASKAARETSQRLINAKKVQMAAKEKLSPDIISTALESGHF
TDEGLVDTMMTFLAAGHETSAAALTWTMFLLAKNHDIQDRLQEEI
RQNVDGLTDDVDAKKLDSLSYLHAVCQESLRLYAPIPFTVRDALKDTRILGTFIPK
GTMVILCPWAINRAHELWGPDADEFNPERWMAPGQANSGGSKSN
YAFLTFLHGPRGCIGQKFSLAELMALTCALVGRYRFDIDKDYEVRDIADGIVAKPSKGLKVFVEEVQGW*
>CYP617C1 Fusarium graminearum FG10461.1
AACM01000435 FGcontig1.435_scaffold7
MSVIGLWLVTVTATLSLFVWQLIFLLSIPKSIVVCLIAESLFFVAWFFYW
TVIYPRYLTPFRHLPTPASRSILTGNQNGLFTENSWDVARRVSQTVPNSG
LIRYYVALSNERILVTNTRALSDVLTNHSHDFGKSNLAKFALKRLTGNGL
GFLEGNEHKVHRKNLMPAFTRKHVKELTPIFWDKAMEMVKGMEAEVRCGK
DTSTQGTGIVEIHDWATRATLDIIGTAGFGYDFGTLHNPSNEIGQQYKKM
FLEPSTAFNWLELLGNYIDFRFLMTLPVKKNRDLTAGSNFMREIAKKVIR
ERRHELFQRMTSQAGNMKNTKKDIITTALASDCFTDDQLVDHVMAFLVAG
HESTATAFEWAMYELGHRPEMQKRVRDEVRTYLPSPSAGGVKNITFESVP
YLQAICNEVLRLYPFLPFATRVAEKDTWVADQFVPKGTIVAYAAHISNRD
SELWSGPALDAFDPERWMEPGKESSGGANSNYAMLTFSAGPKSCIGEAWT
RAELPCLVGAMVGSFEIELVEGKQADGTVYPTVDFKMGKVLKSRDGVFVR
LRRLEDW*
>CYP617D1 Aspergillus nidulans AN1884.1 38%
to 547A1 46% to 617A1 547 clan
MAPIPWGMLYVSVVGYSVLTSNLFTFFVLATALTALKIVYASFLYPEYLT
PIKHIPTPPLTAQKRSWVRGNTDTYVVISPFEGMLNWTKSVPNNGLLRYY
IIGNIEQVLVTTPKALSELLVQNAYDYQKPESIRISLARIAGEHGILLVE
GQEHKRHRKNLMPAFSYRHIKDLYPTFWAKSVEMVKCIEKDLQDRRDTGD
ITVTVRPWASRATLDIIGLAGMDRDFGSLADPQNELAAQYHRILEDPPLW
LKLLFAAAFVLGNEELVMALPVKRNRDIAEGAKYVRQVAQQLISEKRERI
KHNPEKAEGGGGGKDILSVALNSGNFTDIELIDQMMTFLAAGHETTSSAL
QWSVYALCKHPDIQTRLRQEIRSNLPSVSSNDPKPITAEAVDSLPYLHAF
CNEVLRFHPSVPITFRTTTRDTTLAGTLLPKGTQLTISPEVINHDPDLWG
PDAHIFNPDRWLGPGRANTGGASSNYALMTFLHGPRSCIGQGFAKAELAC
LVAAMVGRFEMELADPGKKLAVRRTATISPVDGVVARLTPLDGW*
>CYP617D2 Aspergillus fumigatus Af293
GenEMBL
XP_749561.1
61% to 617D1
MTVKIPWPAVYLAIAASVYMRPQYAILDSLTATFVVLSLAVTSFRIIYAFVLYPKFFTPIKHIPTPSNWS
WLTGNTSSYLIESPFEEMIEWAYKVPNNGLIRYYIFGNLERVLLTNPKALSELLVTKVYEFPKPQLVRQS
LARVTGKHGVLLVEGDEHKRQRKNLMPAFSYRHIKNLYPIFWSKSIEMVKLIEKDLHSRADAKDNIVRVS
EWASRATLDIIGVAGMDHDFGSLHDSNNELTKHYRRLLEEPPLAMRIIFVLGVLFGSVGVVESLPLKRNR
EIRESSLYIRDVARQMIRKKEAKMKSQASAETGTDIVSVALESGAFTEEELVDQMMTFLAAGHETTSTAL
QWSVYALCKHPDVQTRLREEVRTHLPPISPEHPEPLSAATLDSLPYLNAFCNEVFRFHPSVPGTVRDAAK
DTTLLGYPIPKGTRILVSPEVINHSKELWGPDADQFNVERWLGSGRANTGGASSNYSFLTFLHGPRSCIG
QGFAKAELACLVAAIVGRFQMELKDADAKLEVRRSATVAPKDGVLARFTPLEGW
>CYP617D2 Neosartorya fischeri
95% to CYP617D2 Aspergillus fumigatus = ortholog
NFIA_081070
MTIKIPWPVVYLAIAASVYMRPQYTILDSPTATFVVLSLAVTSFRIIYALVLYPKFFTPIKHIPTPPKWSWLTGNTSSYL
IESPFEEMIEWAYKVPNNGLIRYYIVGNLERVLLTNPKALSELLVTQVYGFPKPQMVRQSLARVTGKHGVLLVEGDEHK
(0)
KQRKNLMPAFSYRHIKN
LYPTFWSKSIEMVKLIEKDLHNRADAKDNIVRVSEWASRATLDIIGVAGMDHDFGSLHDSNNELTKHYRRLLAEPPLAMR
IIFVFGVLFGSVGVVQSLPLKRNREIRESSLYIRDVARQMIRKKEAKMKSQASAETGTDIISVALESGAFTEEELVDQMM
TFLAAGHETTSTALQWSVYALCKHPDVQTRLREEVRAHLPPISPEHPEPLSAATLDSLPYLNAFCNEVFRFHPSVPGTVR
DAAKDTTLLGYPIPKGTRILVSPEVINHSKALWGPDADQFNVERWLGPGRANTGGASSNYSFLTFLHGPRSCIGQGFAKA
ELACLVAAIVGRFQMELKDPDAKLEVRLSATVAPKDGVLARFTPLEGW*
>CYP617D3 Aspergillus fumigatus Af293
GenEMBL
XP_754149.1
55% to 617D1
MGPIHNYFGVVCLGIAASVYFRPECALYGSRIATFAVLLTGIAISKLLYQLFIYPQFVTPLKHFPAPPNR
HWLTGNTGSLLVDTPHALMKEWAKTIPNDGILRYYIVGNMERLTVTSPAVLREILVSKAYEFAKPLVIQQ
TLRRVLGNGILIAEGEEHKFQRKNLKPAFAYRHVKDLYSVFWSKGTEMTKLIRNDLQSRKAPDDNTIQVR
TWASRSSLDIIGLAGMGRDFGSLQDPENSLSRSYEMIFATPGLGTKILFILGMLLGNTTWLAKLPTKQNR
LIDTGCRNIRDATRRMIREQKAKMEDPNAAAEVDIISVAMRSGNFDDDNLVDQLMTFLGAGHETTAGALQ
WAIYALCKHPDVQSRLREEVRANLPPIHGENPGPIDAATIDSLPYLNAVCNEVIRFHPSVPNTVRVALND
TTLMGHPIPKGTQVVISPELVNHMPALWGPDAERFNPDRWMGPGKANTGGAASNYAFLSFLHGPRSCIGQ
VFAKAELACLLAAVVGSFAFELKSPDAPLEVREGATIAPKDGVLAKFTPVEGW
>CYP617D3 Neosartorya
fischeri NRRL 181
NZ_AAKE03000007, NFIA_062490
93% to 617D3 Aspergillus fumigatus = ortholog
54% to 617D1, 46% to 617A1
19kb from PKS 51% to chr 6 Nectria PKS
name changed from CYP617D5, revised seq
3/11/2009
MGPIRNYSGVLCLGIAAGVYFSPECAIYGSRIATIAVLITGITISK
87863 LLYQLFIYPQFVTPLKHFPAPP (0) 87798
87742
KRHWLTGNTGSLLVDTPHALMKEWAKTIPNDGILRYYIVGNMERLTITSPAVLSEILVSKAY 87557
87556 DFAKPLVIQQTLRRVLGNGILIAEGEEHK (0) 87470
87411
FQRKNLKPAFAYRHVKDLYPVFWSKGTEMARLIRKDLQSRKAPDDNTIQVRTWASRSSLDI 87229
87228
IGLAGMGRDFGSLQDPENSLSQSYEMIFATPGLGTKILFILGMLLGNTTWLAKLPTKQNK 87049
87048
LIDTGCRNIRDATRRMIREQKVKMEDPNAEAEVDIISVAMRSGNFDDDNLVDQLMTFLGA 86869
86868
GHETTAGALQWAIYALCKHPDVQARLRDEVRANLPPINVENPGLIDAATIDSLQYLNAVC 86689
86688 NEVIRFHPSVPNTVRVALKDTTLMGHPIPKGTQVVISPELVNHMPALWGLDAEQFNPDRW
86509
86508
MGPGKANTGGAASNYAFLSFLHGPRSCIGQVFAKAELACLLAAVVGSFEFE 86356
86355 LKYPDAPLEVREGATIAPKDGVLAKFTALEGW* 86257
>CYP617D4 Aspergillus oryzae
GenEMBL
BAE57429.1
53% to
617D1, 63% to 617D2, 54% to 617D3
MMGLPWATVYIVIAGYAIAKSTFGNFILLSILVSLLKVFYNWVLYPDFFTPIKKIPSPPGRSWITGNSDT
VFLEAPYEHMRKWLENVPNDGLIRYYVSINLERILPVGPRALKEILVTKSYDFPKPEFIRASLKRLAGEH
GLLLVEGDDHKKSKKNLLPAFAYRHVKEMYPIFWSKSIEMVRVMDEDLRKKADPTDNVLRMGAYASRAAL
DIVGVAGMDHDFQSLRDPNNKLVRTYQNLMSEPPLYMKIIFLLTLLLGDPAVVHDLPLERNRSIERSSET
IRDVARQMIRQKRAKWESGSSTAEDIDIVSVALRSGNFTEEELVDQMMTFLGAGHETTSTA
LQWCVYVLC
KHPDVQTRLREEIRANLPPISTENPQPPAATDIDNLPYLNAVCNEVLRYHPSVPATIRCASRDTTIIGEP
IPKGTLFLIAPEIIGKSKELWGPDADKFNPERWLGPGRANNGGADSNYANLTFLHGPRSCIGQGFAKAEL
ACMVAVVVGKYHMELKNPNAPLEIRQQATVCPKDGVLAKFTNIEGW
>CYP617D4 Aspergillus flavus
100% to CYP617D4 Aspergillus oryzae
AFL2G_02761 revised
MMGLPWATVYIVIAGYAIAKSTFGNFILLSILVSLLKVFYNWVLYPDFFTPIKKIPSPPGRSWITGNSDTVFLEAPYEHM
RKWLENVPNDGLIRYYVSINLERILPVGPRALKEILVTKSYDFPKPEFIRASLKRLAGEHGLLLVEGDDHKKSKKNLLPA
FAYRHVKEMYPIFWSKSIEMVRVMDEDLRKKADPTDNVLRMGAYASRAALDIVGVAGMDHDFQSLRDPNNKLVRTYQNLM
SEPPLYMKIIFLLTLLLGDPAVVHDLPLERNRSIERSSETIRDVARQMIRQKRAKWESGSSTAEDIDIVSVALRSGNFTE
EELVDQMMTFLGAGHETTSTA
LQWCVYVLC
KHPDVQTRLREEIRANLPPISTENPQPPAATDIDNLPYLNAVCNEVLRYHPSVPATIRCASRDTTIIGEP
IPKGTLFLIAPEIIGKSKELWGPDADKFNPERWLGPGRANNGGADSNYANLTFLHGPRSCIGQGFAKAEL
ACMVAVVVGKYHMELKNPNAPLEIRQQATVCPKDGVLAKFTNIEGW
>CYP617D6 Aspergillus niger
e_gw1.4.269.1|Aspni1
61% to CYP617D2
MAGLPWNAIHVGIAVFTYFRSTFRNFLLLSAVTLVLRVFYRLALYPVYFTPLKHIPTPPGRAWFTGNNDSFILVNPYERM
RRWNQDIPNDGLIRFYLAGNLERMIATNPKVLSELLVQKVYDFEKPKIVRQSLGRITGEHGVLLVEGAEHKQQRKLLMPA
FSYRHIKNLYPVFWSKGIEMVKLIEADLQRRANPADNVIRVASWSSRATLDIIGLAGMNRDFDSLQNPTNQLAVAYHKLN
SVPPTPLEKGLFVIGLILNVPHLVHKLPFKRNRYIRESAAYIRNVAQEMIHDARQSIEGEKTHQTTDAVDILSVAIESGG
FTDEELIDQMMTFLAAGHETTSGALQWCVYALSQYPDIQTRLREEIRANLPPISVEAPEPISAATLDSLPYLHAVCQEVF
RFHPSVPNTVRIANRDTTLVGQKVPKGTVIQIVPALTNHDKSLWGPDADQFNPDRWLGPGKANTGGATSNYAFLTFIHGP
RSCIGQGFAKAELACLLAAFVGRFQFELEDPKKELILREAATVTPKDGVRVKVTPLEGW*
>CYP617D7 Aspergillus clavatus
77% TO CYP617D5
ACLA_043510
MGLVGNHLGVLYLAVAAAVFFKPDYAVWGSRIATVILLFTAITVSKVVYQLFLYARFFTPLKHFPTPSNRHWLRGNAPSV
LVDTPHAQMKEWAKNVPNDGIIRYYIVGNMERLTVTNPTALSEILVSKAYDFAKPLVIRQALARVLGNGVLIAEGDVHKF
QRKNLKPAFAYRHVKDLYPVFWGKGAEMARRIRKELQDRKSPEDNTIQVRNWASRSSLDIIGLAGMGQDFDSLRDPENTL
SRSYEMIFATPGLGTKAMFMLGILLGDATWLAKLPTKRNKLIDAGCRNIRDATRRMIDDQKRKMQDPTAEARVDIISVAM
RSGTFDDETLIDQLMTFLGAGHETTAAAVQWAIYALCKNPAVQTRLRAEVRANLPPINLDAPTPIDAGTVDSLPYLNAVC
NEVLRFHPSVPNTVRVALKDTTLLGKPVPKGTQVVIAPELINHMPDFWGEDGGQFNPDRFMAPGMANTGGASSNYAFLSF
LHGPRSCIGQGFAKAELACLLAALVGSFEFELRDPAAPLEVREGATIAPRDGVLARFTPLDGW*
>CYP617D8 Aspergillus clavatus
78% TO CYP617D2
ACLA_090250 revised
MVTMIPWPAVYLATAAGVYLRPQYTIWGSSIATFILLSIVITTIRVVYSLILYPSFFTP
MKNIPSPPTRHWFTGNTSSYLIRTPFEEMIEWARTVPNTGLIRYYIVGNKERILLTSPKALGELLVQKVYDFPKPEMVRL
SLSRVTGKHGVLLVEGEKHKKQRKNLMPAFSYRHIKDLYPVFWSKSIEMVKLIESDLRRRADTEDNVIRVSEWASRATLD
IIGVAGMDHDFGSLRNSQNELTKHYERLLSEPSVGMRIIFVVGILLANLQVIQSLPLKRNREFRESSQFIRDVARQVIRE
KESKMKDGQSAPGSGIDIVSVALESGAFTEEELVDQMMTFLAAGHETTSTALQWSIYALCKHRDVQTRLREEVRSNLPAI
SAENPEPLSAATLDSLPYLNAFCNEVFRFHPSVPGTMRETARDTSLVGYPIPQGTRILISPEVVNHSKELWGPDADQFNV
ERWLGPGRANTGGASSNYSFLTFLHGSRSCIGQGFAKAELACLVAATVGRFEMELKDPEAKLEVRLSATVAPKDGVVAKF
TPLEGW*
>CYP617D9 Aspergillus terreus
64% to CYP617D4
ATEG_05929.1
MAVPFGVIYIALAAYTLTRSTINNFLLVSVITALAKLVYNLVLYPDFFTPIKHIPTPATRSWLKGNTRSIFIESPFAQMR
KWQKEVPNDGLIRYYITGNLERILLTKPKALSELLVYKVYDFPKPEFIRSNLAPITGEHGVLLVEGDEHRKQRKNLMPAF
AYRHIKDLYPIFWAKSTEMVRTIEKDLKNRTDPTDNVVRVGTWASRATLDIIGVAGMDHDFNSLQDPDNNLVQQYHKIMT
EHPKYVKVAFVLAMVIGVPNLVSKLPFKVNIQTKESSEVIRAVARDMIRQKKEKLENKTAKNSVDIISVALESGTFTEDD
LIDQMMTFLGAGHETTSTALQWAAYALCKHPDVQTRLREEVRSNLPSISTDNPEPLSAATLDTLPYLNAFCNEVLRFHPS
VPATIRIAARDTTLVGAHIPKGTLILLAPEVVNHSHELWGPDADQFNPDRWLGPGKANTGGATNNYAFLTFIHGPRSCIG
QGFAKAELACLVAAMVGKFQMELKYPDAPLDVRRGATVCPRDGVLAKFTPLEGW*
>CYP617E1 Aspergillus fumigatus Af293
GenEMBL
XP_753139.1 also EAL91101.1
45% to
617C1, 36% to 617A2
MISFLGLWLCTVTLASGGIFHQALAGGEHTALHFQVLGAHVVAFVAFAVYW
MILYPRYFTPFGNIPTPSRRRILTGNYPVLFPDNAWVPLRELAETTPNDGLLRIYSALSGEALLVTSPPA
IRDMLTVNAFDFTHQDLVKIAIRRFTGSNLERTQLHRKNMMPAFTVPHVRKLTSIFWAKAQEMVRCMSNE
LRADSFARIDFREYMSRATLNNIGLAGMGHDFQTLKQPDTDLRSHHRKLILDPTRVFSWVGLLSRYFDMR
LLMRVPLKKLIEISQSAKYLRELTTAVIQGRREQLVVAENNRGKDIITVALAGGVFDEHHLVDHVMTFLT
AGHESTATAFEWTMYELGRRPEMQSRLRDELRATIGTDLAAVNFGLRVQNLPYLNAFCSEVLRCYPFSPI
IVKVAQKETMLIGQRIPKGTVVLYSAEVSNHDKTLWGPDADKFDPERWMGAKKAKSGGASSNYAMLTFGA
GPRNCIGANFARATLECLVAAVLSTFEIELANPDTAGRLKFGQTKKSAEGIYGRLKFVQPVEV
>CYP617E2 Aspergillus niger
estExt_GeneWisePlus.C_100429|Aspni1
80% to CYP617E1
MMITFLEFWLCTLCLTSGGVVHQVFTGGQHIALLFQVLGGHLVTLLGFALYWTVLYPRYFTPLSNIPTPSHRSIFTGNYP
VLFPDNAWVPLRRLAETTPNDGLLRIYSALSGEALLVTSPPAIRDMLTVNAFDFAHQDLVKIAIKRFTGSNLGFLSNDDF
KIHRKNMMPAFTVPHVRELTSIFWTKAKEMVHCMSTELRADPLAPINFREYVSRATLDNIGLAGMGHDFQTLKQPDNDLR
SHYRKLILDPTRVFSWVGLLSRYFDMRLLMRVPLKKLIEVSQSASYLRSVTKKVIRERSEKLFESDDGRTKDIITVALTS
GVFEERHLVDHVMTFLTAGHESTATAFEWTMYELGRRPEMQTRLRDELRESIGTNDLGATDFGSQVQALPYLNAFCSEVL
RCYPFSPIIVKVAQQDTTIMSHPIPKGTVVLYSAEVSNHDKKLWGPDADQFNPERWMGEGTAKSGGSSSNYAMLTFGAGP
RNCIGANFARATLECLVAAVVTTFEIELANPHTAGRLKFGQTKKSAEGVYGKLRFVQPVEA*
>CYP617E3 Aspergillus clavatus
77% to CYP617E2
ACLA_098900
MIGFEMSAILAFAVYWMVLYPRYFTPFRNLPTPPQRRILTGNYPALFPDNSWLPLRKLAENTPNEGLLRIYSALSGEVLL
VTSPPAIRDMLTVNAFDFAHQDLVKIAIKRFTGSNLGFLSNEDFKLHRKNMMPAFKVSHIRKLSHIFWQKSQEMVRCMAD
ELRLNPDTSINFREYVSRATLDNIGLAGMGHDFNALKEPENNLRTHYRKLILDPTKVFNWVGLLSRYFDMRILLKVPLRK
LVEISKSANYLRGITGEVIQQRKEKLVADEDLRDKDIITVALASGVFEEDHLIDHVMTFLTAGHESTATAFEWTMYELGR
QPEMQKRLRAELNEAIGSDLAMTDFEKRVQSLPYLNAFCSEVLRCYPFSPIIVKVAKQSTTITGERIPKGTIVLYSAEVT
NHDKRLWGPDADVFNPDRWMGEGNAKSGGAISNYAMLTFGAGPRNCIGLNFARATLECLVAAVVITFDIEPANPDTAGKL
KFGQTKKSAEGVYGRLKLIRP*
>CYP617F1 Gibberella moniliformis (also Fusarium verticillioides)
AF155773.4
fumonisin
biosynthetic gene cluster,
FUM15
46% to
617A1, 43% to 617B1, 42% to 617D2, 37% to 617C1, 32% to 617E1
possible GC
boundary after GNRE to remove short intron before heme
signature
(lower case seq)
MRGLNNIAVALALSAIWSFGLDLGRHGTSGSSLLLALFRTLCKA
YPFVVISHFVWSAIIWPTFFSPLRQLPNVPSDGWLSKETLRLVSEPRGVPQSDWINSL
SNRPVDLARYRSFLGFERLLIISPKALAEVLTTKSYDFRKPGLIVSELKQATGMGVLL
AEGSEHKSQRKALQTAFNYRHIKNLYPVFWDVAGEFATVLEKQIPTGTPRTSDTTAVI
DIVDWASRATLDIIGRAGMGQGFDAIQNDDSRLHQAYRMIFEPSRGAIFLALLRLIFP
ERLVNWLPLRRNKRMRHGIQVIRSKCQELIRERKEKIKRQKAGVDNSGNDILTVALLN
GVFTDEQLIDQLMTFLAAGHETTATALTWAIYILCKQPEVQNRLREEIRMHFPNPKGW
PRSERPSSNTLQQAIDFKLPYLNVVCLEVMRYFAPIPLTMREATCDTTILHTFVPAGT
RIILAPRVTNRDSALWGPDANNFNPDRWLSPKNGNRE (0)
ARSNYADLTFLHGPRSCIGQSFARVEFAILLATLIANFEFQIEDESL
LDERNISISRGATSRIVGGLKVRVRPIAVV
>CYP617F2 Aspergillus niger
e_gw1.1.329.1|Aspni1
54% to 617F1
MSGIVSGGATLLTAILSYDSPKISLGTIWFQIPLLLLLTWVTWRRLVWPNFFSPLRHLPSPHNRGWGMNQRLRVYTEPRG
MPQCDWVNSIPNNGLIRYRTLLNSDRLLVTSPEALAEVLTTKCYDFKKPKWLANELKKVLGVGLLLAEGDEHRAQRKILA
PAFSFRHIKNLYGVFWDKSCEVVTAMTDQLSCKEGPKTYGPRESSIVNTGVLDIAEWSHRATLDMIGIAGMGRDFGAVHN
PNADLVRAYALVFQPSKQDIMLAVLRLLLPNWMVDWLPLRRNEEIRCAVQRIRGECADLIRQKSKHQRKYHTSQHRDILD
VALSYGGFSDTLLIDQLMTFLAAGHETTATAITWAVYLLCVHPEVQTALRSEIREKLPSLEDSGSNLTSDNIDTMTYLNA
VCDEVLRYAAPVPLTFREAVIDTNILGQPVPKGTKIILVPRATNRDANLWGPDAQQFKPDRWLEGGIRSNYATLTFLHGP
RSCIGRSFAKAEFSILLAALVGRFEFQLEDDQLLDEKRMKVTRTVTARPANGLLVKVTSLAGW*
>CYP617G1 Mgr061 Mycosphaerella graminicola
50% to CYP617A1 Fusarium graminearum
MNTLIRLAAAHVTSFYLTTRTSLPVPGLYLTTFLLFLTQFFLTTIYNVVLYPRFLSPLRHIPQPPGSHWLTGHTRKIMREPSGFPAREWVKSVESKGGLIRYSNWGRERVVPCTPAALAEVLVTKNYDFVKPDQLKHGLGRILGRGILLTEGEEHKFQRKNLSPAFAFRHIKEIYPVFWKKSQELAAYGDAKDEEHKHALGTINVGNWSSRATLDIIGLSGMGQDFNSLADPSNKLSQTYANVLRLPPGNILTKILQFAPMFLPHWLLAALPIKRNADLNEATTVIKQTCRELIASKRALLEKSEKSDDTSNRDILSVALQSNAFDDENLVNQLMTFLVAGHETTATSMIWAIYALCKYPDIQTKLREAIRKSIPSLDSDITAQDIDDCHYLQAFCQEVLRLWPPVSLTLRIAGRDTVIQDQVLPKGTTVLLVPVAVNVSEELWGSDAMEFNPSRWLNADGKCNASGSAKSNYSFLTFLHGPRSCIGQKFAVAEFACLLAAWIGKFNTTFEEGCPHAEGEVQIKGGITAKPAGGLWCNVEEVEGW
>CYP617G2 Mycosphaerella fijiensis
61% to CYP617G1 Mycosphaerella
graminicola
e_gw1.1.212.1
MAPVKQQLSVAIISTILLQRLAAFPLSYPASIAALFFAQWAAYTLCMILVYPRYFSKIRHLPEAPNPHFLLGQTRRIMKE
PSGIPMRDWAQDVPNHGLIKYSVWFQERVLITTPAALSEVLVTKNYDFVKPWHFRHGLARILGIGILLAEGEEHKIQRKN
LSPAFSFRHVKNIYPVFWKKTEHISDTDNMDAEKAAQLHERGVIDVGNWASRATLDIIGLSGMGRDFDSLHDPGNKLNQT
YKSIFNPGRAGRLLQVLGIFIPFWIMRRLPIKRNQELDAATSYIKQTCRDLIAKKREAMSEKGAVGEVDILSVALESGGF
SDEDLVNQMMTFLVAGHETTATAMIWAIYLLCKDKKIQDKLREDIRKQIPNLESEIQASDIDDCHYLQAVCSEVLRLWAP
VSLTMRVADKDTTIQGEFIPKGTTVILCPWAINTSKHLWGEDALEFKPERWLNADGKANQKGGADSNYAFLTFLHGPRSC
IGQRFAVAEFACLLAAWVGKYDTSFEEGSPLAKGELEIKGGITAKPKGGLWCTLKEVPGW*
>CYP617H1 Uncinocarpus reesii
48% to CYP617D3
UREG_01117.1
MAHAALWLGGSLCLTVLLVSTSSSFQSYTWTFLFLIPCPPGRSLWNGHHEELESLLPGEMIGRWIQQVPNDGLLRYYEAG
NQETLLPTTPKAVADVLTHKAYDWKKTDITQALLKKIIGEGLLLSEGDVHRVQRRNLNPAFSFRHIKNLYPTFWKKGNEL
LQAIEDAIKPLPNDKKVITVGPWMRRATLDIIGLGGLGHNFDCIQNPDSFLPREFEKLLAPPPAAALSTAFRFLGSLLDP
TFIEALPSKHAANAKEASRRIRDFSRSLLQEKSKGLKDDHCSEAIDVISIALQSGVFADETLVDQVMTFLAAGHETTATS
LQYAIHLLCKHPEMQTRLRDEIHSNIPSPNGTLPTTVSATQIDSLPYLNAVCNETLRYYPPAPFTVRQAARDTTVLNTFI
PKGTRISIGILAMNRHPELWGPDAETFNPDRWMGPGKGNTGGASSNYGHLTFLEGPRSCIGSGFAKGEMACLLAALVGRF
EFELEDPNKELEISTGVAFAPKDGVRAKVRVVEGW
>CYP617J1 Fusarium oxysporum
51% to 617A1
FOXG_08717
MIETWQIILAGVTLSGYLLASLHTDNQKSMFLLGLLGTLCLETILWCIYR
IFIHPRFISSLRHIPTPEGNHWLWGHGMKLHREPYCSPVREW
NETVPNYG
FLRYLGFFNAERIVLTSPEALHEVLVTQNYSFPKPASLRETAGRFLGIGLILSEGDAHKLQRRSMNPALAPRNIKALYPL
FWDKTREMIERITADRLETVEVVEWASRITLDLIGVAGLGRDFGAIQDGHNEMVKTYNIVFQPSAQARMLHLIESLVPPW
VLTALPIKLNSDMSQAARSIRETCRDVISSKQKKLKEKKLDDMDIISAAIRTGTFTEDGLIDQAMTLLAA
(1)
GHDTTGAAFTWGVYL
LAKHPEVQDRLRHEIRQRLPPLTQAKESPISSVNVDSMPYLQAVCSEILRFYAPVPQTLREAAHDTSILDQFIPKGTRIV
IAPWATNRCSKLWGSDAYLFKPDRWLG
KSAHGGAESKYGFLS
FLQGPRACIGQGFAGAELACLLAGWVGSFEFELRDGVSMDEKNVDVKGGLTARPAGGLHVKVKRLEECRKI*
>CYP617J1 Fusarium verticillioides
90% to CYP617J1 Fusarium oxysporum
FVEG_05955
MIETWQIILAGATVSGYLLALLYPDNQNSIFLLGFLATLCTETALWC
FYRILIRPRFISPLRHVPTPEGNHWLWGHG
MKLYREPYCSPVREWNETVTNDGFLRYLGFFNAERIVLTSPDALHE
VLVTQNYSFPKPASLRETAGRFLGIGLILSEGDAHKLQRRSLNPAFAPRNIKAL
YPLFWDKTREMVERITADRLETVEVVEWASRITLDLIGVAGLGRDFGAIQDAKSEMVETYNIVFQPSAQAR
MLHLIESLVPAWVLTALPIKFNSDMSQAARLIRETCRDIISSKQKKLKE
KKLDDMDIISAAIWTGTFTEDGLIDQAMTLLAA (1)
GHDTTGAAFTWGIYLLAKHPEVQNRLRHEI
RQRLPPLTQAKEFPISSVNIDSMPYLQAVCSEILRFYAPVPQTLREAAHNT
TILDQSIPKGTRIVIAPWATNRCSKLWGNDAHLFRPDRWLG
ESAHGGAESKYGFLSFLQGPRACIGQGFARAELACLVAGWVGSFEFELR
DRGLMDERNVDVKGGLTARPAGGLHVKVRKLEEW*
>CYP617K1 Aspergillus clavatus
50% to 617D2 Aspergillus fumigatus
ACLA_053190
MDTILDFFHHLHAPLMALAIVTVCILRMIHLMILYPTFLTPLRALPTPLNRSWARGNYTNPTASPISQLQHWRAKFPNAG
LIRYYLPGNQERVLVTSVEALNDILVTKASHFTKPMAVRKRLSYITGNGLLLSEGGVHKTQRRALTPAFSFRHVKELYPI
FWRQAMKMADCIESDMTTNIGKGIEVVEVRKWATRATLDIIGLAGLGHDFGSLQNPDNEILRQYQRMRQEPSRVETLLEG
LLSFILPYFDRVVSMLPTRRATIIVEASQCIRALCGKLVQDKKKQNCERLEGQCDIATVALKSGVFTDSELVDQMMTFLA
AGHGTTSHALQWTVYALCKHPGVQERLRAEIRYHLGSPINLNRAVSASDIDGLEYLQAVCSETLRLYPPVPTTTRKSLHE
TMLGGYPIPKGTLFTISPAVINVDPALWGPDSEIFDPERWIGKGRANSGGSRSHHAFLTFLQGPRSCIGATFARGELACL
VAALVGRFQMELEDPKKNEELTKRGVGAAPADGVRVKFKLVDI*
>CYP617L1 Aspergillus clavatus
47% to CYP617A1 Fusarium graminearum
ACLA_062310
MTPAQVFTDSTASLPLRILAISSIAWIIWKVLLYPKIFSPLRRFPGPKDSHFLHGQLWRILSEPVGVPMRDWINTIPNDG
IIRITTIFNQERLILTSSEALSDALVTHNYDWDKPEQMKKGLGRIVGQGVLLASGNVHKAQRKHLLPAFSFRHVKTLYPI
FWEKSCEMVEAITKATTNADNTNNKTSISITDWLRRAALDIIGLAGFGQDFDALGKPHSELNNIYEKVFDQPQNENVMKA
IETLENIFPVAWLGSLPLQHNRDVKKASMAIRQAARKVIRSQEQFKTKTASSILSGNSLLSIASRSEYFTEDNLIDQIMT
FLAAGHETVSTATAWALVVLCRQPAIQERLRKEIRSQLPSPSQGTSTFNAQILDALPYLHAVCNEVLRFYPPVPLTRRVC
VRDTTIQGERVPKGTNILIVPAALNVSKKLWGEDALEFNPDRWMGSGKNNGGASSNFANMTFLHGPRSCIGASFAKAEFA
CLLASIVGRFNFKFSDPDYKAEVLSAGITSRLKHELLLTVEVVEGW*
>CYP617-un1 pseudogene Nectria haematococca
fgenesh1_pg.scaffold_21000071
Necha1/scaffold_21:299839-300774
possibly derived from CYP617A2
37% to 617A2 mid region aa167-258, 33% to 617C1
36% to AP007157.1e Aspergillus oryzae
LAAEGEEHGRQCRTLVPDFSTRPIKALS
PIFSEKSLLLADPWQDGMKGKKLAAKPFEVLEWLSRATLGIIVKAGLGYDIDSLEHLETPIRIAYQ
LMFS
>CYP618A1 Fusarium graminearum FG03961.1
AACM01000168 FGcontig1.168_scaffold2
MKAMEASYATILWGVALAVVGFLSHRIIAIALRPHSSRFNGLPRPKGQQP
FAGHALRILRGGGPNDVYLQWTRQWPDAPFIRCLSWLNEEILLVNSLEAC
REVLQTNAYFFAKPGFFHTLVGEFLGLGLLFSVGEQHKRLRRIIAGPLSR
PSIRKLFPTFVTYSQKLNREIGEALERSKSGIVEIEDLIIRVTLDIIGVS
LLGRELRDFRSESSPLSFEQCYNAILAQPLAGQIISFINPFIPLRWLPVS
ANLNFIRAKSALKTMMEGLIEQRTAEVGAAKLMNEDDKLSDDLLTRMIEA
SAEESQKLSKEELIDITMQVIAAGHETTASALVWTAYSLAKDPASQQSLR
AEIHSLGTEMSAKGIDELPFLDNVIREAMRVHSPTLIIPWEAQKDMTIAG
THIPKGTTVQIVPAMIQLNPEIWGSDADVFRPGRWEDMGGNASSPYAMET
FSNGPRMCPGKALALLNMKVLLVGLIRDFEMEIVDDGKEVELRNPSLTLK
AKSLIQFKMRKVS*
>CYP618A2 Nectria haematococca
e_gw1.35.9.1
Necha1/scaffold_35:311438-313183
63% to 618A1
This gene model seems correct
MFNTHHLPKALVWTVIIVLVGGILQKIIKAVIQPRFSRLRHLPGPQ
(0)
NNQFLVGQALRLLRTPGPNDLFLQ
WMRRWPEAPFIRCLSWLNSEMLLVNNLEACREVLQTNAYSFVKPAFFHTLVGEFLGVGLLFSVGDEHKRLRRIVA
(1)
GPLSRPSVRRLMPVFVNESNALNRKIADAIKEHDQGGME (1)
IETFFTRASLNIIGVSLLGKELHSFRSPSSPLTFEQCYSNILTQPIAGQLISFINPFIPLRWLPVKANIDFVRAK
AALKTMMTELIEQRTDEVLAARGGQSDFVLSDDLLTRMIEASFGEDTRLSKQELIDI
(0)
TMQVIAAGHETTASALTWITYALATHQDVQNRLR
EELSGIEVTSSAAKAIDDLPYLNNVIREALRVYSPTLMAPWEASENMVIAGVEIPKGTMIQTVPAMVQMN
PSIWGDDAEAFVPERWDTLTGDASSPFSIEVFLNGPRMCPGKALALLEIKVLLMAMIKEFQLEMVDTEME
VRNPSLTLKPKDGLHVRVRRV*
>CYP618A3 Fusarium oxysporum
73% to CYP618A1
FOXG_11718
MWPLDLPLVRVVIFVAFAIWLHFIIKTLLRPSFSELRHLPGPK
(0)
GHQFLVGHALRILRGSGPNELYLQWMQRWPKAPFIRCLSWLNSEVLLVNNIET
CREVLQTNAYRFAKPAFFHTLVGEFLGVGLLFSVGN
QHKRLRRIIT (1)
GPLSRPSIRKLFPTFMTYSRKLNSEIDAAIQQNSNGVLE
VEDLFTRVTLDIIGVSLVGKELRDFRSKVSPLSFEQCYNGILAQ
PLAGQIISFINPFIPLRWLPVSANLNFIKAKSALKGMMTELIEQRTSEVAKAKQLGTDSGLSDD
LLTRMIEASSVENQKLSKDELIDITMQVIAAGHETTASALLWTTYALSKDQKSQNRLRTEIYSMNATDMTAKSIDELPYL
DNVIREALRVYSPTLIIPWEALEDIDIAGVRIPKGTTVQLVPAMTQLNPEIWGPDVETFNPDRWDRLSGDALSPYAMETF
SNGPRICPGKALALLNMKILLVGLIRDFKIESVGDEEMEFRNPSLTLKSTMTVRFKVQREG
>CYP618A3 Fusarium verticillioides
87% to CYP618A3 Fusarium oxysporum = ortholog
FVEG_10106
MWLLSISLVRAVTLVILALCLHFIIKTLLRPSFLQLRHLPGPKNHQFLVG
HALRILRGSGPNDLYLQWMRRWPNAPFIRSLSWLNSEVLLVNNIEACREV
LQTNAYRFAKPAFFHTLVGEFLGVGLLFSVGDQHKRLRRITAGPLSRPSI
RKLFPTFVTYSHKLNSEIDAAIQRSSNGVLELEDLFTRVTLDIIGVSLVG
KELRRFRSKTSPLSFEQCYNGILAQPLAGQIISFINPFIPLRWLPVSANL
NFIKAKSALKSMMTELIEQRTSEVARAKELGTDTTLSDDLLTRMIEASSV
ESQKLSRDELIDITMQVIAAGHETTASALLWTIYALSKDQKSQDRLRAEI
LGLNDDDTTAKAIDVLPYLDNVVKEALRVYSPTLIIPWEALEDIEILGVR
IPKGTTVQLVPAMTQLNPEIWGPDVETFIPDRWDRLSADALSPYAMETFS
NGPRMCPGKALALLNMKVLLVGLIRDFRIESVGDEEVEFRNPSLTLKSKK
PLRFKVRRVSEGS*
>CYP619A1 Fusarium graminearum FG09086.1
AACM01000370 FGcontig1.370_scaffold6
MTAYNNVTLSLWALFGALVLYLLTVPGRRGKHLPPGPPTLPIIGNLHQMP
TRKGYLKLAEWAKQYGDMYSFKIGSTTTIVLSNRRLVKEILERRSVISAG
RPAVYGLEKLVFGGHFILLQQPDAPMYRISKKLLHQYFGEPAIDRSHLRI
INAEATQLIRDLMVDPDNFPHHAHRYANSFTMSTTYGIRTPSHDTPHLTA
ITKITAQATSLIAPGRLPPVDVFPFLKLVPERILGNWVTLCTNLGKASDK
LYMYILESVIERRKTKAPRDTFADRCLDNKEYEFSLHELMYLTGAVLDAG
TDTTSSVLITLIQMLCAYPDCLKRAHAEIDMVVGDERTPVWDDFAKLPYI
NQLMKETQRIRPATPISFPHKVLEDIWIDGKLLPKGATIIANVTGLHSDP
NKFKHPGEFHPDHYKGMQKLAQGYANTADENKRDHYAYGFGRRICAGMQI
AERSLFTTFSKVLWAFDISAPKDAQGRPVAMNLDPMTGYTEGTIVMPKPF
KACIKVRSERRRETILREFEEAENNVFAQFDLPKIGEGI*
>CYP619B1 Aspergillus nidulans AACD01000084
revised
MNSLPLLLAAASVGFLYVILTKGRREKGLPP (1)
GPPTLPFLGNLHQIPVKGSYLKFTEWASQYGGLYSLKLGTGTAIVITDPRLVKEVID
RKSSKYSNRPESFVAHTITGGSHLLVMQYGPLWRTMRKLVHQHFMETAVE
KSHIHVQNAGAVQMLRDFCVRPDLHMLHPKRYSNSIIMSLVYGVRTPSVH
TAHMTQLYEMMVRILSL
PFLCTQGMPTDRAFVLFQENW
SKVMEPGNTPPV
DIYSFLHYIPQKLFGNWLSRAKEVRDEMCQLYGQYLDLVVSRRKKIGSTG
SFMDTVLDQNEKLGLTRHQLYFLGGVLMEGGSDTSSSIILAFIHAMTKWP
QVLKKAQAEIGNVIGEDRMPAWSDYGSLPYVAATVKEAMRWRPAVPLAFP
HAAAEDDWIDGHFIPKSSTIIVNGWGMHHNEARFGNPSVFDPDHYKGQTA
LAPELANASDYTTRDHYGYGTGRRICPGIHVAERNLFLAISKLIWAFSIE
PGVDESGKVIEPDLDPRTGYSEGFLVCANDFPCRIMPRSEAKRESIMREY
QRAQEEVFSRFESPSS*
>CYP619B2 Aspergillus nidulans AACD01000105
revised
MNSLPLLLAAAFVGFLYVFLTKGRREKGLPS (1)
GPPTLPILGNLHQIPVKGSYLK (2)
FTEWASQYGGLYSLKLGTGTAIVIT
DPRLVKEVIDRKSSKYSNRPDSFVAHTITGGSHLLVMQYGPLWRTMRKLV
HQHFMETAVEKSHIHVQNAEAVQMLRDFCVRPDQHMLHPKRYSNSIIMSL
VYGVRTPSVHTAHMTQLYEMMGCRLTMRPSSFQERWSKVMEPGNTPPVDI
YSFLHYIPQKVFGNWLSRAKGVRDEMCQLYGQYLDLVDSRRKKVGSTGSF
MDTVLDQNEKLGLTRHQLYFLGGVLMEGGSDTSSSIILAFIHAMTKWPQV
LKKAQAEIDSVVGEDRTPVWSDYGSLPYVAATVKEAMRWRPAVPLAFPHA
AAEDDWVDGHFIPKGSTVIISGWGMHHNEARFGNPSVFDPDHYKGQTALA
PELANASDYTARDHYGYGTGRRICPGIHVAERNLFLAISKLIWAFSIEPG
VDESGKLIEPDLHPTTGYSEGFLVCANDFPCRIMPRSERRRETIMKEYQR
AQEEVFSRFENISS*
>CYP619C1 Aspergillus terreus
CH476602
This P450 is
two genes away from MSAS polyketide synthase
6-methyl-salicylic acid synthase used in patulin synthesis
patulin is a
mycotoxin sometimes found in apple juice.
51%
identical to CYP619B2, 39% to CYP619A1
ATEG_06277.1
MSKWAKQYGGIFSLKRFRNTTIVLTDWKIMKELVDKKSTNFSHR
PPSKVADLITRGNHILMMQYGETWRTMRKLIHQYLMESQCEKEHWKVQEAEAAQMLHD
FLVDPENHMKHPKRYSNSITMSLVFGIRAKSVNDEYMTRLYSLMEKWSLVLETGATPP
VDSWPLLQWIPERFMGYWRRRATEVGDLMTGLYTEVLHVIENRRKAGIYKDSLMDRVL
DKKDKYRFDEHQLAFLGGTLMEGGSDTSSSLILAIVQAMTQYPEVQKKAHAEIDSVIG
TDRSPAWSDFRKLPYINMMIKEAHRWRPVLPLGVVHGLATDDSYNGMHLPKHSTVILN
VWGMHMDPDRFENPDAFIPERYANFPELAPHYAALADGAARDHFGYGAGRRICPGIHL
AERNLFIAVAKLLWAFEFKNNPAGKNDASAETGSSQGFMHCVKDYDAIVTVRGEERRQ
TILRELEQAQTVFAKYD
>CYP619C2 Aspergillus clavatus
EU678354
Olivier Puel
Submitted to
nomenclature committee April 28, 2008
65% to CYP619C1
ACLA_093640
MDFTQVPPSYILGVLLSSTSILFCLKYLLRSGYRPPELPSGPTT
VPLFGNELQVPKADAHFQFTKWAKQYGGMFSLKRYMNTTIVITDRKLMKSLLDKKSNI
YSHRPASLVSHLITQSDHLLVMQYGEEWRMLRKIIHQYFMEPNCEREHWKVQEAEAKQ
MLHDFLTMPEDHMLHPKRYSNSITNSLVFGIRTATVHDEYMDELFYLMDKWSLVQELG
ATPPVDSFGLLRILPQWMLGNWKNRAVEVGDLMQALYSKVLDQVRARRQRGVYRDSFM
DRVLDNLEKTPLTENQLRFLGGVLMEGGSDTSSSLILTIIQAMTKYPEVQAKAHAQID
AVVGSERSPSWSDFAQLPYINMIIKESHRWRPVSPLGVPHAVAEDDRVNNTLIPKGST
IVLNVWGMHHDPDRWSEPEHFQPDRFADYPALASTYAASGEWDKRDHYGYGAGRRICP
GIHLAERNLFIGVAKLLWAFEFSEPLGSRSDISAESGASQGFLHCPKDYGCAIRLRAP
EKRETIMREFEEAQGVFSRFD
>CYP619C3 Aspergillus clavatus
EU678353
Olivier Puel
Submitted to
nomenclature committee April 28, 2008
55% to
CYP619C1
ACLA_093630
MEPMLLLILVAAVVLLFVRWAFVYGHRTSNMPKGPPTLPFIGNI
HQIPTQYTHIKFTEWAAKYGGLYMLKVGNGNMAVVTDRRLVKEVVDRKSGIYSHRPHS
FVSHELITKGNHLLVMHYGDQWRTFRRLIHQHLMESMVDSQHVKIVNAEAIQLVRDYL
VDPEHHMAHPKRFSNSITNSIVFGIRTADRNGSNMKRLYKLMEEWSEIMETGATPPVD
LFPWMKMLPQWMFSNYVNRAKAIGVQMETLYTDILNKVIKRRNGGQNLGTFMDRVLDG
QEKNDLPWHQLAFIGGVLMEGGSDTSSSLTIAIVQALILNPAVQKKAHAEIDAVVGSD
RSPVWEDLEKLPYINMIIKEGHRWRPILPLCFPHALGEDDWVDGKLLPKGTVVVINTW
GMHMDPSQPDDPAAFIPERYANHPQLAPEYAAGKWENRDHYGYGVGRRICPGIHLAER
NMFLAIAKLLWAFEFQRGGGKIDSDPVTGYHNGFLYCAKDYPCRPVVRNKTIRATIER
EFATATKEVFSQFTEG
>CYP619D1 Aspergillus niger
gw1.16.300.1|Aspni1
50% to CYP619B2
GPPGAPLIGNILQLPKVRAHQKFTEWARTYGGLYSFRIGPATAAVVTDRALVKELFDKRSALYSSRPTSYVGQNIITRGD
HLLVMDYSDNWRLFRKAINQHFMASMCEKTHVRLLEAEHTQMMRDFLLHPEKHMLHTKRTTNSIIMSLLFGIRTPSWDTP
HMQELYEIMEIWSQIMETGATPPVDIFPWLHWVPQQWLGHWVDRSQTVARGMKRLYSSFHRRAIEARRKAESTSQSRART
FLDDVLDLQEKLGLTDNQVDFLGGVMMEGGSDTGSTMLLVMIQALALHPEIQQRARAELDAVCGEHRSPTWEDFPRLPYI
NMIVKETMRWRPVTPLAFPHALNKDDWVNGYFLPKGTTVFLNVWGLHHDENIFPNPDQFDPSRFEGRHKLAFDYAASPDY
MQRDHYIYGAGRRLCPGIHLSERSMFLGAAKLLWAFNFEPARDEDGNPIRIDTDPVTGYTEGFLVCPRPYQCNVTPRSPA
HAETILREFSRAESEVLSQYAMP
>CYP620A1 Fusarium graminearum FG02837.1
AACM01000142 FGcontig1.142_scaffold2
MTGASILYFSALAFTTYLIFKYLQQRSKEPLPPGPKGLPLLGNVLDLPPP
GTIEWIHWQKHKEKYGPISSVSVLGQLFVILHDKQTIMDLLETRSLKSAS
RPKLVFAGDVVGYDSIMGMMPYDRTFRLHRKLTATQVSGKSIGRFEPIQE
LEISRLLKRIYNDHNSDNLPEHLNQVSGSIMLRILYNYETDPNKNDHIVS
MANTVMEEFSKATSPGAWAVDLVPWLKYLPEWIPGAGFKKTAKVFRDHLL
QNVKDPYNYVRDQMARGNDHVSYVAGLVEDIHRKIDPEEESVIQWTAASM
MNAGTDTTGATLLSFFAAMVIYPDVQKRAQEEIDRVVGHSRLPSFADKAN
LPYINSIAQEALRWHTLAPMGFPHMTTENDIYKGYFIPKNILLFPAVASV
THDPDVYHDPMAFKPERYSEPYSEPSPADVVFGFGRRACPGKWIAEQTMF
LIIAQTLATFNIEKDLDKDGREIDVVYEQLPGVISRVKPFPHRIVLRSEV
>CYP620A2 Fusarium oxysporum
76% to CYP620A1 Fusarium graminearum
FOXG_15685
MSFSLILVTAIVASLSFFLVKHIQQSKNTPLPPGPKGLPLLGNIRDLPPPGTLEWPHWQTHKEKYGPITSVSVLGQHFVI
LHDRQVIVDLLETQAIKSASRPKLVFAGDI
VGYDGVMGLMPYNRTFRMHRKLTATQVSSKSITRFEPIQELEILRLLKRI
YQDQDPKSQNLPDHLNQ
VSGSIMLRILYNYETDPCRNDHIVTMANLVMEEFSQATTPGAWMVDFIPWLRYLPDWMPGAGF
KRTAKLFRQHLLQNVQDPYKYVKNQMALGNDNVSYVAGLIKDVHRKIDPEEESIIAWTAASMMNAGTDTTGATLLAFFAA
MLLNPNVQKKAQTEIDRFIGDSRLPSFSDKPNLPYINAISQEVLRWHTLAPMGFPHMTTEDDTYGGYCIPKDTLLFPAVA
SLTHDPEIYHDPMEFKPERYFEPCNEPSPMELVFGFGRRACPGRWIADQTLFLSIAQTLAVFEIKKALDGEGREIEVVYE
QLPGVISRVKPFPHRIVLRSEKYRKFLE*
>CYP620A2 Fusarium verticillioides
84% to CYP620A2 Fusarium oxysporum = ortholog
FVEG_13148
MSTSIVIVTAILASLSFLLVKHTLRPKKPPLPPGPKGLPLLRNIRDLPPPGTL
EWPHWQSHKEKYGPITSVSVLGQNFVILHDRQVIMDLLETRAMKSASRPKLVFAGDI
(2)
VGYDGVMGLMPYNRTFRMHRKLTATQVSPKSITRFEPIQELEILRLLKRLHQDPNSQKLPDHLNQ
(0)
VSGSIMLRILYNYETDSDKNDHIVTMANLVMGEFSEATTPGAWMVDFIPW
LRHIPEWMPGAGFKKTAKLFRHHLLKNVQDPYQYVRDQMT
NGKGDVSYVAGLIKYIHRKIDPEEESIIAWTAASMMNAGTDTTGATLLAFF
AAMVIYPKVQKKAQEEISRATGDSRLPSFTDKPNLPYTTAIAQEVLRWH
TLAPMGFPHMTTEDDTYRGYFIPKNTLLFPAVASLTHDPEVYHDPMEFKPE
RYFEPYNEPSPSDLVFGFGRRSCPGRWIAEQTLFLSIAQTLAVFRIERE
VDAEGREIESRLTKTP*
>CYP620B1 Fusarium graminearum FG03700.1
AACM01000161 FGcontig1.161_scaffold2
MGLLLLPAVALAALIVYYVLFPKKQTGLPLPPGPKPLPIIGNLLDLPPAG
TAEYKHWAKHKELYGPISSLNILGQPMIVLNSPDAMHELLEKRSTKTSSR
PSATFGGELCGFKVMLPLIPYGDKFRYFRKLVHQQMGTKLICSEFRDTQD
LESLRFLIRNLERPEELQKHIKTEAAAIILRIIYGYSIEPRKVDPLVSLI
ETMMIHFSDAFVPLSWAVDIFPSLNNLPDWFPGTSFKKTAREWRRVTDQS
LDVPYDFVMKQMSTGTNRPSYVSNLMSKSFKNDQGTGKPTKEDIDAVKAT
ATIMYGGGADTTVSTISSFILAMIKFPEVQKKAQAEIDRVTGGERLPNFD
DEKDMPYIRALCKEALRWMPVVPTTTTHMTEEELEYGGYRIPKGTYLIPS
TWALLHDPEVYHDPSAFEPERYIEPRNEPDPAEYAFGYGRRICPGRYLAE
DSIFMTCVRLLAVFNMRKAVGEDGKEIDVVVDGTPGLISHPVDYAYSITP
RSDKHVELVRAAERAHPWEESDAPSLPKDSLV*
>CYP620B2 Nectria haematococca
fgenesh1_pg.scaffold_19000072
Necha1/scaffold_19:183528-185225
56% to 620B1 Fusarium graminearum, 44% to
fgenesh1_pg.scaffold_24000005
This gene model seems correct DRN 2/6/06
MFLALLQVFLVLVGIVVWRLSVRWKAPRDLPPGPKPLPLVGNIFDLPLPGVPEYQHWIKFKDTYGPLSSV
TVLGTNMILVHSQEVLQDLIVKRSTKTSSRPKQHFAGELCGFDALTPSLPYNATHRLHRKFMHQQMGTRL
ICERFWHVQDVESRRFLLRVLNDPSNIISHIKT (2)
EASAIILRITYGYSIEPHKVDPLVTLIEHMMGNFSDA
LVPLTWSVDLFPFLKHLPTGFPGASFKKIAQEWRERARMAADIPYSFVLRQIANGNPTSSYVSSLVTEYS
KNPENSWKPTDSEVEIIKNSAAIIYGGGADTTVSTLSGFVLAMLLFPEVQRKAQEELDRVVGSDRLPEFE
DREKLPYVNALIKETLRWLPVVPVGTTHVTEEEMFHSGYRIPKGSFLLPSIWWFLHDPAVYPKPEAFDPE
RFLEPRNEPDPANHAFGYGRRICPGRYLADDSLFLTISRLLATFEINKAVDEKGNEINVEVEVTAGLISH
PNTFPYGIKPRSVRHVEMIRSTESEYPWEEPDVRHLEQDHLQYLHVN*
>CYP620B3 Fusarium oxysporum
82% to CYP620B1 Fusarium graminearum
FOXG_09726
MGLLLLPAVVLAALIVYYVLFPKKKTGLDLPPGPKPLPIVGNVFDLPPAGTAEYKHWAKFKDLYGPISSINVLGTPLVVL
NDREALHDLLEKRSTKTSSRPWSPFASELCGYSVFLPVIPYGNKFRYFRKLVHQQMGTKLICSEFRDTQDLESLRFLVRT
IERPEEFQKHIKTEASAIILRIIYGYNIEPKKVDPLVNLIEKMMINFSDAFVPLSWAVDIVPSLARLPDWFPGTSFKKTA
REWRNTTDQALNTPYNFVMDQMASGTNRPSYVSQLMSSKSFKNDNGTGEPTKEDIEAVKATATIMYGGGADTTVSTISSF
VLAMIAFPEVQKKAQAEIDSVTGGERLPTFEDQDRMPYINALCKEALRWMPVVPTTTTHVTEEEIEYRGYRIPKGTYLIP
STWWILHDPEIYANPDAFDPERFIAPRDEPDPSDFAFGYGRRICPGRYLAEDSIFMTVARLLAVFDMRKAVDENGKEIDV
VIDGTPGLISHPVEYAYSITPRSAKHVEMVRAAERVHPWEESDSSLLKKDSPV*
>CYP620B3 Fusarium verticillioides
97% to CYP620B3 Fusarium oxysporum
FVEG_08749
MGLLLLPAVVLAAIVVYYVLYPKKKTGLDLPPGPKPLPIVGNVFDLPPAGTA
EYKHWAKFKDLYGPISSINVLGTPLVVLSDREALHDLLEKRSTKTSSR
PWSPFASELCGYSVFLPVIPYGKKFRYFRKLVHQQMGTKLICSEFRDTQD
LESLRFLVRTIERPEEFQKHIKTEASAIILRIIYGYNIEPKKVDPLVSLI
EKMMINFSDAFVPLSWAVDIVPSLARLPDWFPGTSFKKTAREWRNTTDQA
LNTPYNFVMDQMGSGTNRPSYVSQLMSSKSFKNDNGTGEPTKEDIEAVKA
TATIMYGGGADTTVSTISSFVLAMIAFPEVQKKAQAEIDSVTGGERLPTF
EDQDRMPFINALCKEALRWMPVVPTTTTHVTEEEIEYRGYRIPKGTYLIP
STWWILHDPKIYANPDAFDPERFISPRDEPDPSDFAFGYGRRICPGRYLA
EDSIFMTVARLLAVFDMRKAVDENGKDIDVVIDGTPGLISHPVEYAYSIT
PRSAKHVEMVRAAERVHPWEESDSSLLKKDSPV*
>CYP620C1 Fusarium graminearum
AACM01000001.1 revised
MLLIIVVLVGTLIYFLSFHNKKRHGLPPGPKPLPIIGNIKD
MPPKGVAAFRHWLKHKDTYGPVSSVSVLGQPLILIHDREAAHYLFDKSSG
KSSGRPSANFGGRLCGFDQILSLQQYGDTFKRHRKLVHRQMGTRAGAAKF
RQIQDVESHRFLLRSLDNPGNLMEHIRK (2)
EAGGVILKATYGYSIEPHKPDPLVHLVEFMVEGISIVVVPMKFVVDFLPWLEYI
PECLPGMSFKARARRWRTILNNTIEAPYQFVRQQMAKGIQFESYVSSLLT
QEKLKGGNDTLDETYEADIKRTAAIMYAGGADTTVSTIQSFVLAMMVYPE
VLKKAQAEIDNVIGPDRLPGFEDRENLPYINSMVKESLRWMPAVPMGAAH
KADDDIYYGDLCIPKGSFLLPNVWWFLHNPETYQDPERYDPDRYLEPRNE
PDPDSNCWGYGRRICPGRLLADESIFIVIARVVAAFDIEKDVDEQGNTIE
PKVEFTTEGALSRPVDYPYRIKPRNAKCVDLIRAVEKEHPWDKGDASLLQ
QDMVVL*
>CYP620C2 Gibberella moniliformis
DR662816.1 EST
AAIM01003167.1 50% to 620D1, 51% to 620B1, 54% to 620B2
Also Fusarium verticillioides FVEG_10070
2136 MLSAVLILVGVALTILYIRTKPRKNLPPGPKPLPILGNVKDMPDGTIPEYQHWIKFK
2306
2307
DLYGSISHVSVLGQSLIILHDRQAANAILEKTSTKTSGRPQFVFGNEMCGYNQILPFKPY 2486
2487 GKLLKQHRKLVHQQLGTKTAASRFRDVLDVESRRLLLRILETPEKLFEHIQT
(2) 2642
2695
EASAIILKMTYGYSLEPRKPDPLALLIEQMMHNFSLAFVPMSWPVDVLPILRYLPESLPGM 2877
2878 SFKRIAREWNANMRMVVDVPYTFVKRQIAKQSNRPSYVSSLIKQHDDDMDEETDAAIKQT
3057
AAVMYAGGSDTTVSAICGFVLAMLLFPEVQRKAQQEIDSVVGTERLPQFEDRDNLPYVDALTKESL
RWIPVAPMGAVHTADEDIHYKDFVIPKGASLLPATWWFLHDPEIYSDPTSFDPDRYLEPR
NEPHPNFASFGFGRRVCPGRFLADESLFISISRLLAAFEIKKAVDGRGNEIEPQISVTPG
LISHIRDFPYDIEPRSEKYAAMMRQVEDDHPWEQADATFLNMDGSLESEKV*
>CYP620C2 Fusarium oxysporum (temp CYP620C3)
83% to CYP620C2 Gibberella moniliformis
FOXG_11744
MLPAIFIVIGVVLAIIYIRTRPRKNLPPGPKPLPVLGNIRDMPDGTTPEYQHWIKFKDLYGPISHVSIFGQSLIILHDRD
AANAILEKTSIKTSGRPQFIFGNEMCGYNQILSFKPYGKLLKQHRKLVHQQLGTKTAASRFRDVQDVESRRLLLRILESP
EKLSTHIKTEASAIILKMTYGYNLEPHKADPLALLIEHMMHNFSLAFVPMSWPVDVLPILRHFPETLPGMSFKRIARDWN
ANMRMVVDVPYHFVRKKMAKQSHRPSYVSSLIKQYDEGLDTESEAAIKQTAAAMYAGGADTTVSSIRGFVLAMLLFPDVR
RKAQQEIDSIVGTDRLPQFEDRDNLPYVDALVKETLRWIPVAPMGVAHTADEDIQYKGFVIPKGASFLPAVWWFLHDPAI
YSDPSSFDPDRYLEPRNEPHPNFASFGFGRRVCPGRFLADDSLFISISRLLAAFEIKKAVDGRGNGIEPEISITPGMIGH
IRDFPYDIKPRSEKYADMIRRVELEHPWEEGDAGLLEEELSLYAVNV*
>CYP620D1 Aspergillus nidulans AN3394.1 47%
to 620B1 64 clan
MTYFLLILTPDSTKMAIASLILWGIGTLICYLIYQHSTRSAQRLPLPPGP
KPLPIVGNL
KDFPPDGKPEYQHWIHHKDRYGGISSVTLLGMTLVIIHDKK
AAHELLEQTSGRTSGRPTMVMANKLCGYESIVVCQDYNARFRRCRKFLHQ
ELGTKVSASQFSAAQELEVKRQLVRALNEPEKWLE HFKTT
AGATVLKMAY
DYAVDYHKPDPLVDLIDRMMTEFSLAAVPMAWAVDIIPALQYLPGAPFKK
TARKWRKSIQAAAYIP YRFVQSQMAALTYKPSYVSKLVQLLK GEQSELDH
EDEQAIIWSAASLYGAAADTTVITLTTFTLAMILFPDVQRKAQEEIDRVV
GNRLPGFKDREKLPYINALVLEALRWWPIAPMGFPHTATEGFEYNGLYIP
KGAYLLPAVWWFLHDPEVYDNPEIFDPDRFLEPRNEPTPMTEAFGYGRR
I
CPGRFFADSSLFLNIAQSLAVFNFKK AVSSDGKEIEIDVKPKPGLLTYPT
KFDFRIEPRSERHIQMIRELERQDPLAAGDAEHLESIDNFQPL*
>CYP620D2 Histoplasma capsulatum G217B
ABBT01000228.1 Ajellomyces capsulatus G217B
73% to CYP620D1 but N-term is not detected
HCB07277.1 (fusion to another protein)
Upper part of fusion protein seq is alpha
1,2-mannosyltransferase (deleted)
LPPGA & KPHP
416149 ILGNLK
DFPPDGVPEYQHWLKHKDLYGGISSVTVLGLTLVVI
HDRKTAHELLEQTSSKTSGRPTMVMANKLCGYESIVLCQSYTPTFRRYRKYLHRELGTKVSAAQFRSVQEIEVSRQLVRA
LNEPGKWLERRGER (1)
ATVLKTAYGYTIEPHRPDPLVDLIDKMMTEFSLAAVPMAWAVDIIPALR
YLPENFPGATFKNTARRWKKSILDSAYIPYRFVRRQMAGDHTNQPSYVSKLVQQLR
&
GEDAKLEHEDEQAIIWTAASLYGAAADTTIITLTIFTLAMIKF
PHVQRKAQEEIDRVVGTDRLPNFDDRSQLPFIDALVKEAVRWWPIAPMGFPHTATTEDVVHNDLHIPQGSLLLPAFWWFL
HDPDVYAGPEAFDPDRFLAPRYEPDPTADAFGYGRRVCPGRFLADASLYLTIAQF
(0)
LAAFNMRKAVGEDGREIEVDVRPRLGILTYPTKFDFRIEPRSERH
VQLIRQLERRYPWEPSDAELLESVDDFEAG* 417698
>CYP620E1 Aspergillus nidulans AN1601.1 43%
to CYP64A1 64 clan
65% TO 620H3 name needs revision 620H3 = 620E4
revised 7/18/07
MAPTAILITVPLGLLLYLLFIRPSIAKKQKAPLPPGPPPKPLIGNLRDLP
SPDQKNWVHFLQHRDLYGPISSLTVFGQTIVILNDARVAFDLLEKRSNIY
SSRPRMVFAGEMVGWEHILAMQPYSDMFRAYRKAMHRVLGTKNVIAQFNE
LQDVEARRFLLRVLEKPGDLVQHIR (2)
TETGAVILKIA
YGYDIEPHGKDPLVALANESLANFAVAGTPGAWIVDTIPF
MKYLPSWFPG
TGFKRTAASWKQTLLTTIEKPYRLVLKQLESGKYPDSYLSNLLEETKGRP
LSADEEQVIKWTAGSLYTGGADTT
TVSTLSCFFLAMALYPDVQRKAQEE
LDTVLGSAKLPTFGDRARLPYIEAIVKEALRWHPVAPMGIPHMSTEDDIY
EGYLIPKNSLIMPNIWAFTHDASHYKDPATFNPSRFLGDTPEPDPSTLTF
GFGRRICPGRLLADSSIFLTIAQSLAVFEISSAGEDAAKAEFLPGVISHP
VPYRLDIRPRSKGHEDLVKRIAAESPFGEGGAKELEEIVV*
>CYP620E3 Nectria haematococca
fgenesh1_pg.scaffold_24000005
Necha1/scaffold_24:11514-13534
51% to 620E1, 43% to 620A1 Fusarium graminearum
43% to CYP64A1 Aspergillus flavus
48% to CYP5037B1 Lentinula edodes (Shiitake mushroom) [overlap of families]
MTGLSALILGSAIGVVIVVILKRSFSTA
NGNPPLPPGPNGLPLAGNLNDLPRPGVLEAHHWLKHKGLY (1)
GPISSVTVMGQTLVIINDAQVAFELLEKRSVKHSSRPRQIFVGEM (2)
LGWENS
LGLSQYNDRFRTYRKNMSRIIGSKTAAAQHNTLQEAEVGHFLLHVLDNPEDVVNQIRK (2)
EAGAVILKIAYGYTAEPFKEDVLVNMAGDAMDKFALAGVPGAFMVDMMPF
(1)
LRYLPDWVPGTGWKRTARQWAAELHNVTEKPYAFVKHQIA
QGKDDNSFLARLLETGDSTPEEKFTNKWSAMSLYTAGAGT (0)
TVSALACFFLAMSISPDVQRKAQEEIGRVIGKDRLPTLADRPNL
PYIDAIVKEVLRWHPVAPMGLPHTSTADDVCEGYFIPKGSMLFANVW
(2)
HFTHDPKVYDEPMSFKPERFLPDDGSEVAPDPYTFVFGFGRRICPGRILADNALYVNIA
QSLAVFDITRGDPVAQPEIR
FTPGVVSHPEPFKATIKPRSPHHEK*
>CYP620E4P Fusarium oxysporum
64% to 620E3, end badly
frameshifted
FOXG_13772
MFEISTFFSGVALGFLLYISIGVIRNGSKRPPLPPGPKGLPLLGNLSHLPPPGVFEAHHWLKFKDLY
(1)
GPISSITVMGQTIIIINNWKLASQLLDKRSAKHSSRPKIMMAGEM
(2)
VGWENSLGFSPYNDRFRTYRKNMARIIGSKRAAAKYDRLQEAEVAHFLLHVLDDPERFMDHIRK
(2?)
EAGSVILKIAYGYTAEPSKEDILIK
MAGQAMDDVTAAGVPGAFLVDILPL (1)
LRYVPDWVPGANFKRLAKKWSSELDDLTEKPYAFVKHQHASGKQDNSFVSRLLEVGDSTE
EARFTTKWSALSLYAAGADT (0)
TVSSISLFFLAMILYPDVQKKAQEEIDGVIGNERLPNCSDRQSLPYVNAIVKEVLRWHPVAPMGLPHTSTVDDVFEGYF
VPKDALIMPNIW (2)
YFAHDPEVHHEPMRFNPERFLSTDGNQPEQDPHMYTFVF &
GVRVCPG & RV & IADMHCFYNI &
IQSLAV*HIRKDENDAQP & EL &
LFTLGMISHPEPFKAAITPRSPHHERLIRSVEQEYPWEQSDGHIIENMQRQAS*
>CYP620E4P Fusarium verticillioides
84% to CYP620E4P Fusarium oxysporum = ortholog
FVEG_11206
MFEASVFFAGFALECLIYTGLQILGNVSKRPPLPPGPNRLPLIGNLNDLPPPGVFEVHH*LKH*LKFKDLY
(1)
GPISSITVMG*TIIIINNWKLASQLLDKRSAQHSSRPKIMMAGEM
(2)
VGWENSLGFSLYNDRFRTHRIN
MARIIGSKRAAAKYDRLQEAEVAHFLLHVLDDPERSMDHIRT (2)
EAGPVILKIAYGYTAEPFKEDILIDMAGQAMDNVTAASVPGAFLVDTLPL
(1)
LPYVPDWVPGANFKRLAKKWSSELDDLTEMPYAFAKHQHALGKQDNSFASRLLEIEDSTEEARFTTKWSALSLYAAGADT
TVSSISLFFLALILYPDVQKKAQEEIDGVI
GNERLPNCSDWTILPYANAVVKEILRWNPVVPMGLPHTSTEDDV
FEGYFIPKDALIMPNIW (2)
YFAHDPEVHQDPMRFEPERFLSTDGNQPEQDPHTYTFGFGRRVYPGRVL
ADNALFLNIAQSLAVLHIRKDENGAQPKLLFTPGMISHPEPFKAAITPRLPQHEQLIRSLEQEFSWEQSDNHIIEKMQRQAS*
>CYP620E5 (old CYP620H3) Aspergillus oryzae
GenEMBL
BAE55186.1
55% to
620H1, 56% to 620H4, 65% to 620E1
revised 3/17/2009
MPLPTLGSVLLGLAFLYFVKLVLLRKKTLAPLPPGPKPKPIIGNLRDLPRPGQQEWTHWLKFKELYGPIS
SVSMFGQTIVILNDHQAAFDLMEKRSAIYSSRPRLVFAAEIVGWEDVITLQGYTNRFRSYRKAMHRVLGT
KELMSRFNPLQDVEVRRFLLRILQKPDELIQHIKTEVGAVILKIAYGYNIEPHGRDPLIDLVNDSMENFS
AVVKPGTWLVDVIPLLKYLPTWFPGAGFKRTGYEWRKTLLATIEKPYQLVKQHMRQGSYPPSYLARLLEQ
IDGEPTAEEELVSKWTAGALYAGGADT
TASSLSSFFLAMALYPEVQRKAQKEIDRVVGPNKLPTFED
RDTLPYIDAMVKETLRWHPVGPMGVAHLVTEDDIYEGYLIPKGALILPNIWGFTHDPKIYRDPETFRPER
FLGDNPELDPHTLAFGFGRRICPGRLLADATIFLTIAQSLTVFNFSKPEGEGDLKAEFLPGVISHPAPYR
LEITPRSAAHEALIRSVEVEHPWEESHAKELEKVEC
>CYP620E5 Aspergillus flavus
99% to CYP620E5 Aspergillus oryzae
AFL2G_00089
MPLPTLGSVLLGLAFLYFVKIMLLRKKTLAPLPPGPKPKPIIGNLRDLPRPGQQEWTHWLKFKELYGPISSVSMFGQTIV
ILNDHQAAFDLMEKRSVIYSSRPRLVFAAEIVGWEDVVTLQGYTNRFRSYRKAMHRVLGTKELMSRFNPLQDVEVRRFLL
RILQKPDELIQHIKTEVGAVILKIAYGYNIEPHGRDPLIDLVNESMENFSAVVKPGTWLVDVIPLLKYLPTWFPGAGFKR
TGYEWRKTLLATIEKPYQLVKQHMRQGSYPPSYLARLLEQIDGEPTAEEELVSKWTAGALYAGGADTTASSLSSFFLAMA
LYPEVQRKAQKEIDRVVGPNKLPTFEDRDTLPYIDAMVKETLRWHPVGPMGVAHLVTEDDIYEGYLIPKGALILPNIWGF
THDPKIYRDPETFRPERFLGDNPELDPHTLAFGFGRRICPGRLLADATIFLTIVQSLTVFNFSKPEGEGDLKAEFLPGVI
SHPAPYRLEITPRSAAHEALIRSVEVEHPWEESHAKELEKWSVNG*
>CYP620E6 Aspergillus clavatus
63% to 620E5, 61% to 620E1 (subfams 620E
overlaps with 620H)
ACLA_072970 revised
MESLAVHALLGLTVLYVVNRLFLTKRTPAPLPPGPSPKPIVGNLGDLPPSDAHHWEHWLKHKELYGPISSISVFGQRIVI
LNEAKVAFDLLEKRSVIHSSRPEQVFAGKMVGWENSLAVQTYSDRFKSYRKAMHRVMGSKSVVSEFDSLQDVEVRRFLLR
VLRDPAGLVQHLRTEAGAIILKIAYGYTIDPHKPDILVDLADQALGEFSKAAAPGKWLVDLVPMLKHIPTWFPGAQFKRT
AQEWKARVVATAEQPYAFVRQQMKLGSHKPSYVSSLLEARPLGSHSEEEEWVIKWSAMSLYTGGADTTVASLASFYLAMA
LYPDVQRKAQDELDRVVGCNKLPTFADREQLPYIDALVKEVLRWHTVGPMGLPHTSTQDDIYEGYFIPKGSMFLPNIW
AFTHDPNVYKDPMVFNPERFLGPTPEPDPHTIAFGFGRRICPGRILADRTVYLGIAKSLAVFNFGK
STEDQQPLFLPGVISHPAPYKLNITPRSPEHEELIRSVEIDHPWEESDAAALRNLEY*
>CYP620E7 Aspergillus terreus
55% to CYP620E5
ATEG_02682.1
MSTTLLLKAILAIASLYIVKLFLSGKRGAQPLPPGPVPKFIIGNFHDLPPHGVKDWEHWLRHKDLY
(1)
GPISSVTVLGQTIVVVNDAELAVELLEKQSAATASRPRLVFASELL
GYGLSLPMQTDLQRTRAYRKAMHHVIGSTKSMADFHPLLEREVRRFLLR
TLRTPKELIQHLKT (2)
LTGAIILEIGYGYTVEPHGPDPFVDLANKVMAEFSVATQPGTWAPDIIPALKYIPSWFPGAEFQRMAKTFNSRVNDFSGKPYAFVQKK
MARGSYKPSYLSRLLEKDNPQPGSEEELVARWSAASLYGGGSDTTLSSLGSFFLAMAMYPDIQRKAQAEIDRVAGNRLPT
FNDRAELPYTEAVVKELLRWLPVAPMALPHRATDDRSCGGYLVPRDALILPNVWGFLHDPEVYHDPMTFNPERFLGSTPE
PDPRKFAFGFGRRVCPGKALAEANAFLAVAMSLAVFRIRDAKQNGRKIDGYPDVTAGVISHPVDFEVEISARSAAHEALI
ESVEKDCPWQEGDGKECDF*
>CYP620E8 Aspergillus terreus
72% to CYP620E5
ATEG_07797.1
MALYTLVGTLVALAVVYLLKQLLLSKPPTAPLPPGPKPKPIVGNLGDLPPPGQQEWKHWLQFKKLYGPISSITIFGQTIV
IINDAQVAFDLMEKRSSIYSSRPRMVFAGEMVGWNDALAMQTYSDKFRAYRKVMHRVLGSKAVTARFNPLQHVEIRRFLL
RVLDKPNDLLQHIRTEAGAVILKIAYGYTIEPHGRDPLIDLANESMDKFSVAGTPGRWMVDTIPFLKYLPTWLPGTDFIR
TGNAWRKTLLTTIEKPYQLVLQQMKQGSCPPSYTASLLEEANGNATPEEDLVIKWTAGSLYTGGADTTVSALSCFFLAMT
LYPDVQRKAQEELDRVLGPNRLPTFEDRDNLPYIEALVKETLRWHPVAPTGIPHLCTEDDLYNGYLIPKGALILPNIWAF
THDPNVYRDPASFKPERFLDTDGTAPELDPHMLAFGFGRRICPGRFLADSTIFMSIAQSLTVFRFEKDPAVTAQPEFLPG
VVSHPTPYQLKITPRSAQHEALIRSVEVEHPWEESHAKEIEKIECVV*
>CYP620F1 Aspergillus fumigatus Af293
GenEMBL
XP_747154.1
O-methylsterigmatocystin oxidoreductase predicted
46% to
620D1, 48% to 620B1, 44% to 620C2, 38% to 620A1, 38% to 620E1
MAYELSTLQLSCVAFVAFMAVLVFRTRTRNLKQNVPPGPRPLPIIGNFFDLPPKGQPEYLHWFKHKDAYG
PVSSINVMGTTLVIFHDKDAAHAVMGKKAQKTSARPQLNFAQLCGFENFLITHQYNDKYRLHRKMVHQEI
GTKGLSAGFRPIQEQESIRFILQTFNRPDDILQHLKTLAAAIVLKITYGYSIERKGQDPLVELIEHAMEN
LSQAFVPLAWAVDSVPAIKYLPDWFPGMSYRKTARKWRAINEAAAELPYDFVKRQMAHKAHQPSYVSNLL
EKHMIKSEDNKINVSAADEEAIKWTAVSLYAAGSDSTVAIIHSVICGLVMFPEVVTRAQEEIDRVVGSDR
LPNFDDRTNLPYVDGIIKEAWRWNPVGPMGLTHKSEEDLVCGEYLIPKGSYLLPSLWWFLNDPKEYPEPR
VFKPERYMEPFNHPDPSEIAFGYGRRSCAGRYFADASVYITVVQLLAVFNVRKARDDQGNEIPVTLQAIP
GMVNRPAPFQFKVEPRSQHHIDLLRRIESEQIPEVSHASLLKPSTV
>CYP620F2P Mycosphaerella fijiensis
estExt_fgenesh1_pm.C_10155
62% to CYP620F1
MDYIKIQRSLGY (0)
LAVGILLSLAFLTARVQRLQ
MPLPPGPKPLPLVGNVLDLPPSGVPEFKHWFRHKDKYGPVSSVTLMGLVLVIIHDKEVAYSLLSKKAQKTAARPQFNFAS
LAGFEQFLITHQYNDTYRLHRKMVHHKVGTKSLSGAYRKP (0)
EREATLFVLQVYKNPAARMVHSKT (2)
LAAAVIVKVMYGYEIERDGRDPLCEVIEHAMDNLSQAFVPLKWA
VDAIPAIQYLPDGVPGTGSRKTAAEYAKVNYQAANLPYAFVKQQMQAKTERPSYVANLLKSQAAKHGGMSKLPPEEEGAI
KWTAVSMYAAGSDSTVAIMQSVICALLIHPESVTRAHEEIDRVVGSSRLPTFADRKNLPYVDGIIKEAWRWNPVGPMGLA
HRSEEEMIIKGYRIP*GTYLLPSLWWFLHDPA
TYSDPEAFNPERYLPPLNEPDPS
DIAFGYGRGSCAGRFFADASVYITMVQFLACFDIRKARDANGREIPVKLEPVAGMVNRPKPFAWEVEIR
SAKHTELLEGLKSMLEQLRGDSALLDLA*
>CYP620G1 Aspergillus oryzae
GenEMBL
BAE59625.1
52% TO
620H3, 48% to 620H4, 46% to 620E1
revised 3/18/2009
MMYTLSTLVFLAGILGLYVLLNSKAPRAPLPPGPKGLPIIGSVGSDLPRGGRDWEHWLKHKELY
(1)
GPISSITTAGHTHIILNDANVATELLEKRSARYSSRPRLVMANEL
SGSDIFVTTQNEHAIVRALRKRILSQLRSEE
VLLSFYPQVDTLIRRFLLRTLQKPEELIGNIKT
GIGGVILKVVYGYTVEFHDRDPLVDLVGETAVAFGRI
NQPTGYLVDSIPA (1)
LKYLPSWFPGAGFKKEAREYRRGFDTLLNWPFTFARRQMEEGNYEPSFVSRLIE
QRGSLLSLEEEVKIKHAAAAVYQAGYDTTASTITSFFLAMALFPAAQHKAQEEIDRVVGARLPTPEDRGK
LPYVNALINEVLRWNPVAQIGIMHAATEDDIYEGYLIPKGAPIVPNIWAIAHDPDVYSDSMSFKPERFLA
SDGHTPERDPHTLVFGFGRRICPGRPLTDFNNFLTIARSLAVFQVQKATKDGKEIDPIVDYQGGIIGHLS
PFEVSIRPRSAEHEALIRSIEVEDSISRGDSAALESVRV
>CYP620G1 Aspergillus flavus
98% to CYP620G1 Aspergillus oryzae
AFL2G_07111 revised
MYTLSTLVLLGGILGLYVLLNSKAPRAPLPPGPKGLPIIGSVGSDLPRGGKDWEHWLKHKVLY
(1)
GPISSITTAGHTHIILNDANVATELLEKRSARYSSRPRLVMANEL
()
SGSDIFVTTQNEHAIVRALRKRILSQLRSEEALLSFYPQVDTLI
RRFLLRTLQKPEELIGNIKT ()
GIGGVILKVVYGYTVEFH
DRDPLVDLVGETAVAFGRINQPTGYLVDSIPA (1)
LKYLPSWFPGAGFKKEAREYRRGFDTLLNWPFTFARRQMEEGNYEPSF
VSRLIEQRGSLLSLEEEVKIKHAAAAVYQAGYDTTASTITSFFLAMALFPAAQHKAQEEIDRVVGARLPTPEDRGKLPYV
NALINEVLRWNPVAQIGIMHAATEDDIYEGYLIPKGAPIVPNIWAIAHDPDVYSDPMSFKPERFLASDGHTPERDPHTLV
FGFGRRICPGRPLADFNNFLTIARSLAVFQVQKATKDGKEIDPIVDY
QGGIIGHLSPFEVSIRPRSAEHEALIRSIEVEDSISRGDTATESVRV*
>CYP620G2P Aspergillus niger
gw1.10.879.1|Aspni1
60% to CYP620G1 partial C-term seq Pseudogene
IQAKAQEELDRVIGTNLPTTEDRTHVPYINAVIKEVLRWNPVTPLGVAHASTKEDVYEGYSIPKDATMVPTIWAFLHDPK
VYSDPMTFNPERFLTTESYQAERDPHNLAFGFGRRICPGRGFADSTIFLVRSLQAFRVAKIFEDGREIGPVVDYLPGVMG
HPKPFAISITPRSKEHESFIRSIEIEHPWERGNLVLV*
>CYP620H1 Aspergillus oryzae
GenEMBL
BAE60302.1
69% to
620H2, 53% to 620H4, 49% to 620E3,
48% to 620G1
MMLVVSLLLGLTGLYIIRWTLGERKTLKRLPPGPTSKPVIGNLLDLPSPGTPDWLHWLKHKELY
GPISSVTIFGQTIVILNDRQTVIDLMEKRSGLHSSRPQLPIAEI
(2)
TDWDDTLGLIPYNSRFRAYRKALHQEMGTPAS
ILKYHDIIDMETHRLLFRILENPEDLVQHIRK ()
EAGSIILRVGYGYVTEPHARDPLVDLVDKAMEDFSQLV
LPGAWLVNFIPMLKYLPSWFPGNGWQETAKAYKKRVTAMRDVPYTFVQRQIKKQNHVPSYVSSLLEQGNV
EPGSEEEIVAKWSAQSLYGGGAETSVSSLACFFQAMVLNPNVQKRAQEEIDRVVGTSRLPDMSDRENLPY
INAVVKEVLRWHPVTPLGVTHAASEDDTYNGYFIPKGSILVSNIWAIAHDPELYHDATEFKPERFLGVNG
RTPEYDPHLLSFGFGRRICPGQHLAAANLYLAIARSLAVFDITHLVKNGKEVPVTPEFTTGIISHPAPFE
LSIRVRSPEHEKLIRAVEKSYPWEKSHAEELQLKI
>CYP620H1 Aspergillus flavus
99% to CYP620H1 Aspergillus oryzae
AFL2G_02999
MMLVVSLLLGLTGLYIIRWTLGERKTLKRLPPGPTSKPVIGNLLDLPSPGTPDWLHWLKHKELY
(1)
GPISSVTIFGQTIVILNDRQTVIDLMEKRSGLHSSRPQLPIAEI
(2)
TDWDDTLGLIPYNSRFRAYRKALHQEMGTPASILKYHDIIDMETHRLLFRILENPEDLVQHIRK
()
EAGSIILRVGYGYV
TEPHARDPLVDLVDKAMEDFSQLVLPGAWLVNFIPMLKYLPSWFPGNGWQETAKAYKKRVTAMRDVPYTFVQRQIKKQNH
VPSYVSSLLEQGNVEPGSEEEIVAKWSAQSLYGGGAETSVSSLACFFQAMVLNSNVQKRAQEEIDRVVGTSRLPDMSDRE
NLPYINAVVKEVLRWHPVTPLGVTHAASEDDTYNGYFIPKGSILVSNIWAIAHDPELYHDAIEFKPERFLGVNGRTPEYD
PHLLSFGFGRRICPGQHLAAANLYLAIARSLAVFDITHLVKNGKEVPVTPEFTTGIISHPAPFELSIRVRSPEHEKLIRA
VEKSYPWEKSHAEELQLKI*
>CYP620H2 Aspergillus oryzae
GenEMBL
BAE61267.1
69% to
620H1, 49% to 620H4
MLVLVSLVLCLTGFCLLQWALKERKIVKGLPPGPRPKPIIGNLLDLPPPGALDWLHWLKHKELY
GPISSVTIFGQTIIIINGHRVANELMEKRSGVHSSRPHVPIAEL
()
AGWQYTLGFIPYDSRLRAYRRALHQEMGNATS
ISKYHNILDMETHRLLFRILKTPDCLMQHLRKEAGSIILRITYGYITEPEAYDPLIDLVDKAMEDFAQVI
LPGGWLVNFIPML
KYLPSWFPGCDWQRRAKAFKQRAKAMTDIPYAFVKQQHEQQKHIPSYVSRLLEQNNI
KLGSEEELVVKWSAQSIYGGGAETSVSVFACFFQVMALHLNVQKKAQEEIDRVVGASRLPDLSDCKNLPY
INAVVKEVLRWHPVAPMGVAHASSKEDIYHRYVIPKGAILVPNIWAMAHDPDFYHNAMDFEPERFLKSGR
NEQNPEYDPHQFIFGFGRRTCPGQHLVSANLSLGVARVLAVFNITNAVRDGKKVPISPEFSPGVISRPAP
FELSIQVRNAECKRLIEAVGMKFPWEESHAEALAQLRI
>CYP620H2 Aspergillus flavus
99% to CYP620H2 Aspergillus oryzae
AFL2G_09608 revised
MLVLVSLVLCLTGFCLLQWALKERKIVKGLPPGPRPKPIIGNLLDLPPPGALDWLHWLKHKELY
(1)
GPISSVTIFGQTIIIINGHRVANELMEKRSGVHSSRPHVPIAEL
(2)
AGWQYTLGFIPYDSRLRAYRRALHQEMGNATSISKYHNILDMETHRLLFRILKTPDCLMQHLRK
(2)
EAGSIILRITYGYITEPEAYDPLIDLVDKAMEDFAQVILPGGWLVNFIPM
(1)
LKYLPSWFPGCDWQRRAKAFKQRAKAMTDIP
YAFVKQQHEQQKHIPSYVSRLLEQNNIKLGSEEELVVKWSAQSIYGGGAETSVSVFACFFQVMALHLNVQKKAQEEIDRV
VGASRLPDLSDCKNLPYINAVVKEVLRWHPVAPMGVAHASSKEDIYHGYVIPKGAILVPNIWAMAHDPDFYHNAMDFEPE
RFLKSGRNEQNPEYDPHQFIFGFGRRTCPGQHLVSANLSLGVARVLAVFNITNAVRDGKKVPISPEFSPGVISRPAPFEL
SIQVRNAECKRLIEAVGMKFPWEESHAEALAQLRI*
>CYP620H4 OLD name = CYP620E2 Aspergillus oryzae
AP007164.1b CYP64 like
second P450 of six on this accession
seq assembly modified at cyan region
CDS
complement(join(1111497..1111884,1111943..1112214,
1112271..1112515,1112568..1112719,1112780..1112971,1113193..1113425))
53% to CYP620e3
MASLHLASIAIGVLTAYLLTKLLTFKKPPAPLPPGPPPKPIIGN
LKDLPQNGERDWEHWLKHKELY (1)
GPISSITVLGQTFIILNDQKLAVELLEQRSKWHSDRPKMFFAAEM (2)
SGCGGILGLIPYSDRSR AIRKAMN
KEIGSKVAVSRFNALQEAETRRFLLRVLEAPEELRNHIRT EAGAVVLKLAYGYTVEPH
KQDPLVDLADVSMYYFSLVCRYGAWVVDVFPSLR FLPSWFPGTEFKRIGQRSKEAFDN
FGGKPYNFVKHQMSQGTHHPSYLSSILESEEIEPGSEKEYVTKWSAASIYAGGADTTV
STMASFFLAMALYPEAQRKAQEEIDRVVGNSRLPTFADRDNLPYINATVKEVLRWHPV
VPNNLPHLSTHDDMCQGYFIPKGSIVISNIWGFAHDPDVFHDPMTFKPERYLGDNPEP
DSHRISFGFGRRICPGRVMADAAIYLNIAQSLAAFNIGKKVVDGKEVEPRVEFQAALI
SHPEPYDVSIKPRSSVHEELIRAVEEEYPWEKSHADELVNIKV
>CYP620H4 Aspergillus flavus
99% to CYP620H4 Aspergillus
oryzae
AFL2G_06042
MASLHLASIAIGVLTAYLVTKLLTFKKPPAPLPPGPPPKPIIGNLKDLPQNGERDWEHWLKHKELYGPISSITVLGQTFI
ILNDQKLAVELLEQRSKWHSDRPKMFFAAEM
SGCGGILGLIPYSDRSRAIRKAMNKEIGSKVAVSRFNALQEAETRRFLLRVLEAPEELRNHIRT
EAGAVVLKLAYGYTVEPHKQDPLVDLADVSMYYFSLVCRYGAWVVDVIPS
(1)
LRFLPSWFPGTEFKRIGQRSKEAFDNFGGKPYNFVKHQMSQGTHHPSYLSSILESEEIEPGSEKEYVTKWSAASIYAGGADTTV
STMASFFLAMALYPEAQRKAQEEIDRVVGNSRLPTFADRDNLPYINATVKEVLRWHPVVPNNLPHLSTHDDMCQGYFIPK
GSIVISNIWGFAHDPDVFHDPMTFKPERYLGDNPEPDSHRISFGFGRRICPGRVMADAAIYLNIAQSLAAFNIGKKVVDG
KEVEPRVEFQAALISHPEPYDVSIKPRSSVHEELIRAVEEEYPWEKSHADELVNIKV
>CYP620H5 Aspergillus niger
e_gw1.10.144.1|Aspni1
59% to CYP620H4
MWTGAFIAITSVYIFFAVLTRKSKRPPLPPGPRRKPIVGNLWDLPDPSQQDWQHWLKHKDRYGPISSLSIMGQTIIVLND
ARLAVELLESRSSIHSSRPQQHFAEMAGWNNVLGAVKQSQRFRATRKNLHREIGSNVSVARFNEIQTAEVGRFLLRVLDA
PDKLMKHIRKEAGAIILKVGYGYTIEPHDQDPLVDLADKAMMDFSMAMLPATWAVDFFPPLKYLPSWFPGTEFMKIAQRY
RKNVTAFSDIPYAFVKEQMRTGRFVPSFLSNLLESSDLEPGSEEENTVKWSAGSLYAGGADTTVSSIASFFLAMALFPEV
QRKAQQELDTVIGTDRLPQYADREQLPYINALVKETFRWHPVVPMSLTHTSTADDVCEGYFIPKGSSVLANIWAFTHDPA
AYHDPMSFKPERFLGPKPERDPHFLVFGFGRRVCPGRTLADVNVYLTVAQALAVFEISKPVENGKVKDVQPEFLPGVISH
PAPFDVSIRPRSAKHLELLRSLEQKYPWEKSNAEDLK
>CYP620H6 Aspergillus niger
fgenesh1_pm.C_scaffold_4000144|Aspni1
60% to CYP620H1, 41% to CYP64A1
MLSIASLLVGLASIYVLYVFLGPKKTSAPLPPGPPPKPVIGNLNDLPPPGSKDWQHWLDHKEKYGPISSVTIFGQTLVVL
NDPDMALEMLEKRSAKHSSRPHLPIADLSGWDKTLGLLPYNNRFRAYRKATYRELGSANAVAKFDGIVDKEVTRFLLRVI
RSPNDLIDHLRKEAGAIILRIGYGYTIEPNARDPLVDLVDKAMDDFSQIVLPGAWLVNFVPFLKYLPTWLPGGKENQIAK
EYKERLTIMHDKTYDFVKNQMARGVHQPSYVSGLLEKDTVLPGSEEEIVVKYSAGALYGGGADTTVSALSCFFMAMALNP
SVQKKAKEEIDQVIGTSRLPDLSNQNDLPYINAVVQEVFRWHPVTPLSVSHASSEEDIFNGYLIPKGAIIVPNVWAFTHD
PTNYRNPETFNPDRFLGAAPEPDPRLYAFGFGRRICPGRLLAEKSIFLTVARALAVLDIRKKVRDGKEVPIRVEFSSGTI
SHPVPFEVDLKPRSKGHEKLVGAVEREFRGRRVMRRSWGSEDMDDWYIAR*
>CYP620H7 Aspergillus niger
e_gw1.1.1438.1|Aspni1
53% to CYP620H1
MSLLVRAITGLLGLLILKSFLTRKKFLAPLPPGPKPKPIIGNLLDLPSKGEADWLHWYKHKKIYGPISSVQVFGETLIIV
NDARIAVELMEKRSVIHSDRPSLTFIEMSGFKDIFSMRNNNDPRVRAERKLFYQQIGSNNSVARFNYIQEAEVGRFLVRV
RDNPEGLQDHIRKQAAAIILKLAYGYSVVPHGDDPLVDLIGRAMGNFGAALVPGVWLVDFVPFLRHIPTWFPGATFARVA
ETFRESARAWNCQPYEFVRYQMSQKKHAPSYISGLIEEKGVPEPGSFDEVVMKWSAAAMYGGGSDTATTISTMGGLFLAM
VLYPDVQRKAQEEIDRVVGTDRLPGFDDRDNLPYINAMVKESLRWHSVLPMGVAHCSSEDDMCEGYFIPKGSQILPNQWA
FTHDPDVYPDPMAFKPERFLATENHTPERDPHLLAFGFGRRICPGRTLADANIYLSIAQSLAVYRFTKAIKNGKEVDVEP
KFLTGAISHVAPFEVGIKPRSQQHEALLQALEAKFPWEKGHAEELSQVKF*
>CYP620H8 Aspergillus niger
e_gw1.6.1233.1|Aspni1
54% to CYP620H3
MSILTAVAFTCLILLPVYLLINHQIASLPLPPGPKGKPIIGNLSDLPPPDTPEWQHWLEHKKRYGPITSVTILNQPIIIL
HDAQIAIELLEKRSLKYSSRSQTVFVGEMIGWKDTLGMQPYNARFRAYRKAMHQVLGTKALVSKFNTLQELEARRLLRRM
LEDPGEWVQHLKTEAGAIILKIGYGYDINPHGRDKLVDLADDSMETFSAVMNQVWLVDLVPVLKYLPSWLPFSAQRKSQF
WRTQLLTTIETPYRMVREQMASGIAPPSYLSNLLQEEDTKEEKTLTAEEEFTAKWTAGSLYIAGADTTVSALRTFILSMA
LNPAIQEKAQAELDTVLGPHTLPKLSDRDKLPYVNAVVKESLRWYPVGPMGIPHLCVEEDVYDGYRIPKGAIVMGNIWAI
THDPNIYPHPEKFDPERFLGENPQPDPSGWVFGFGRRVCPGRVLADASVFVTVGMVLSAMRISLEKGDGEREEVRFTPGV
VSHPVLAGLKVEARSARHEGVIREVSI*
>CYP620H9 Aspergillus oryzae
GenEMBL
BAE60640.1
58% to
620H7, 56% to CYP620H5
revised
3/18/2009
formerly
CYP620J1
MSYMVLGLAIGVIFLYFIRSFLARTKSFAPLPPGPRPKPIIGNLWDLPPQGTRDWLHWLKHKDLY
GPVSSVTVFGQTIIILNEARLAYELLEKRSAIHSSRPSCTFAHM
AGYGDIMTILEYSERLRT
TRKVAHQQIGSNKAISRFSHIQDAEVCRYLLRMLRDPGNWLEHIKKQVETGAVILKITYGYTVEPHGRDP
LVDLAEDAVGKFSLAMVPGAWLVDSIPI (1)
LRHLPSWAPGGGCTRAAEGFQTAARNLGNVPYA
FTKQQMTQGSNVPSIISYYLESENIQ
PGSEEEHLVKWATATLYGGGADTTVSTMMCFFLTMALYPHVQRKAQEEIDRVVGATRLPGFEDRGNLPYI
DALLKEALRWHPIVPMGVAHMAMEDDMLEGYRIPKGAAILSNIW
AFTHDPNEYHDPMTFKPERFLSDNGHTPERDPHLLAFGFGRRVCPGRNLADSNLWLTIARTLAAFNIAKPIRDGKEVD
IQPEFQAGLISHPEPFDVDIKLRSAGHHELILAGEKQYPWEESHAEELRRAIAVL
>CYP620H9 Aspergillus flavus
57% to CYP620H7, 98% to CYP620J1 Aspergillus
oryzae
AFL2G_03370
MSYMVLGLAIGVIFLYFIRSFLARTKSFAPFPPGPRPKPIIGNLWDLPPQGTRDWLHWLKHKDLY
GPVSSVTVFGQTIIILNEARLAYELLEKRSAIHSSRPSCTFAHM
AGYGDIMTILEYSERLRTTRKVAHQQIGSNKAISRFSHIQDAEVCRYLLRMLR
DPGNWLEHIKKETGAVILKITYGYTVEPHGRDPLVDLAEDAVGKFSLAMVPGAWLVDSIPI
(1)
LRHLPSWAPGGGCTRAAE
GFQTAARNLGNVPYAFTKQQMAQGSNVP
SIISYYLESENIQPGSEEEHLVKWATATLYGGGADTTVSTMMCFFLTMALYPHVQRKAQEEIDRVVGATRLPGFEDRENL
PYIDALLKEALRWHPIVPMGVAHMAMEDDMLEGYRIPKGAAILSNIWAFTHDPNEYHDPMTFKPERFLSDNGHTPERDPH
LLAFGFGRRVCPGRNLADSNLWLTIARTLAAFNIAKPIRDGKEVDIQPEFQAGLISHPEPFDVDIKPRSAGHHELILAGE
KQYPWEESHAEELRRAIAVL
>CYP620H10 Aspergillus oryzae
GenEMBL
BAE64937.1, AP007171.1
51% to
620H4, 51% to 620H3, 43% to 620E1
14 P450 genes
and 2 pseudogenes on this contig
revised
3/18/209, formerly CYP620K1
MESILLFLTISLVGLYLVGSHLSKKHSLGHLPPGPPRKPIIGNLTDLPSHDVCDWEYWLKHKDLY
GPISSLSIFGDNIVILNDARFARDILEKRSSIWSSRPSWNFGKM
AGWNKILGTLAYSDPSFKDMRKAIGHQIGSKTAASRFN
AVQDLEVRRFLLRVLEDPDNLLQHIRK ()
EAGAIVLKIAYGYTIEPHGHDPLVDLADEAMATFGLAILP
GTWVVDFIPILKHVPTWFPGAQFARMAKQFRKSAAAFSDVPYAFVKRRLAQRDFEPSFLAGLIRKNEEQP
GPGSYEETVIKWAAASFYGGGSDTTVSTMSSFFLVMAQYPHVQRKAQAGIDCVVGPDRLPSFQDRENLPY
IYAMVKEILRWHPVLPMGTAHASVMDDTYEGYTFPKGTLMVPNVW (2)
AFTHDPSTYPDPHTF
KPERFLSYEGHEPEANPYYLVFGFGRRVCPGRTLADANLYISIAQSVAAFTITKPIRDGKEVDLRAEYQS
GAISHPVPYNVTITPRSPRYEELIRAVETEHPWEKSHSEELRLV
>CYP620H10 Aspergillus flavus
99% to CYP620K1 Aspergillus oryzae
56% to CYP620H5, 57% to CYP620H9
AFL2G_05207
MESILLFLTISLVGLYLVGSHLSKKHSLGHLPPGPPRKPIIGNLTDLPSHDVCDWEYWLKHKDLY
(1)
GPISSLSIFGDNIVILNDARFARDILEKRSSIWSSRPSWNFAKM
AGWNKILGTLAYSDPSFKDMRKAIGHQIGSKTAASRFNAVQDLEVRRFLLR
VLEDPDNLLQHIRKEAGAIVLKIAYGYTIEPHGHDPLVDLADEAMATFGLAILPGTWVVDFIPILKHVPTWFPGAQFARM
AKQFRKSAAAFSDVPYAFVKRRLAQRDFEPSFLAGLIRKNEEQPGPGSYEETVIKWAAASFYGGGSDTTVSTMSSFFLVM
AQYPDVQRKAQAEIDCVVGPDRLPSFQDRENLPYINAMVKEILRWHPVLPMGTAHASVMDDTYEGYTFPKGTLMVPNVW
(2)
AFTHDPSTYPDPHTFKPERFLSYEGHEPEANPYYLVFGFGRRVCPGRTLADANLYISIAQSVAAFTITKPIRDGKEVDLRA
EYQSGAISHPVPYNVTITPRSPRYEELIRAVETEHPWEKSHSEELRLV
>CYP620H11 Aspergillus terreus
58% to CYP620H5
ATEG_07254.1 revised
MSPILIATAIGLVAFYVLKWVSTKRLRVALPPGPPRKPLIGNLGDLPSHTDKAWEYWLKHKDLYGPISSLTVCGQDIIII
NDAHIAVDLLEKHSSAHSSRPHATLVEMAGWEDILTSVPYGDHFRAIRRALHQEIGSKVSVARFNHIQEVEARRFLFRVL
DDQKSLVHHIRKEVGAIVLKLGYGYTIEPHKRDPLVDLADRAMEEFSFSILPATWAVDFLPFLKYLPAWLPGAEFKRMTA
TFRKTATAFSDLPYAFTKHQMTQPSHVPSFLSHQLEKGIPRPRSSEEKVAKWSAASLYAGGTDTTVSTMTAWYIAMALFP
DVQRKAQEEMDRVTGGNRLPSYEDRENLPYINAMIKESVRWHSVVPMNVAHVSIQDDSVGEYAIPKGTQIVTNLW
(2)
AFTHDPNIYPDPMAFKPERFIDTATHKAERDPYYYSFGFGRRVCPGRTLADANIYITMAL
SVAAFNISKPVRDGKEVEVKLDPQPGIICHPAPVELDIKPRNQVIERLIRAVETDYPWEKSHAELLTSLPY*
>CYP620H12 Aspergillus carbonarius
FD661712.1 EST
81% to CYP620H5
TFAGGADTTVSSISSFFLAMALFPEVQRKAQEELDAVVGTNRLPQYEDREQLPYINALVKEVL
RWHPVVPMSLAHTPIKDDTIEGYSIPKGATVLANIWELVKQSN
>CYP620L1 Fusarium oxysporum
51% to CYP620E3 Nectria haematococca
FOXG_13173
MESASLIVYTGVITFVFIYVTKLLAKTSHNAQLPPG
PRGLPLVGNVLDLPRAGEFEAHQWAKHKDLY (1)
GNISSITVFRQTLVIINDAKLAQTILNDRSAKHSSRSKMTFAGEM
(2)
VGWDKTLSFLPYNGQLRSHRKKAHVCLKSEASIK
TNDAIQEIEVGHFL
LHLLRDPDRLVEHIQK (2)
QAGSVIVKVVYGYTAEQFKPDPLLITVRKVVDEFGIAAKPGAFMVDLIPI
(1)
LKYVPEWFPGAVFKSTAKQWRSNLESSVEDPAAFVEYQMANGKDNTSFLSQLLQKKS
LTDEEYSENKWLAASLYAAGADT (0)
TVSAITTFFLAMTLFPEAQKKAHYEIDEVIGRDRLPTLSDRQSLPYVNALVKEVLR
WHPVGPMCLPHTTSQDDVIDGYLIPKGAMILPNIW (2)
QICHDSALYHDPMAFRPERFLGPEAETDPGRFVFGFGRRICPAQAMSDKTLFLNMAQTLVVFD
IGVKEGAEMPKAEFTSGVVSHPKPFETEIKPQSSQTRKLIESIERMHPWQQSDAETLASL*
>CYP620L1 Fusarium verticillioides
87% to CYP620L1 Fusarium oxysporum = ortholog
FVEG_12380
MELATLITYTCVITPVLICVTKLIAKTSRNAQLPPGPRGLPLIGNVLDLPRAGQFEAHHWARHKDLY
(1)
GNISSVTVFGQTLVIINDAKLAQTTLNDHSAKHSSRSKMTFAGEM
(2)
VGWDKTLSFQPYNEQLRRHRRKAHLCLKSEASIR
SNDTLQEIEVGHFLLHLLRDPGRLVEHIQK (2)
QAGSVIVKVVYGYAAEQFKPDPLLSTVRKVVDEFGIAAKPGAFMVDLIPILKHIPDWFPGAGFKTTAKQWRTNLESSVEDPAAFVQHQMANGKDNK
SFLSQLMQKKGLTDEEASENKWLAASLYAAGADTTVSAITTFFLAMTLFSKAQKKAQWEIDEVIGSERLPALSDRQSLPYVNALVKEVLRWHPVGPMCLP
HTTSQDDIIDGHLIPKGAMILPNIW (2)
QICHDPALYHDPMAFKPERFLGSEAETDPGRFVFGFGRRICPAQGMADKTLFLNMAQTLAVFEITGKEGGEMPKAEFTS
GVVSHPKPFETAITPRSSQHRKLIESIERMHPWQKSDADTLANPHR*
>CYP620M1 Mycosphaerella fijiensis
45% to CYP620E1 Aspergillus nidulans
44% to CYP620H5 Aspergillus niger
e_gw1.22.354.1 revised
MIAHPVFAAWLSFVTALILLTIHHVRRVSIKLPPGPRRLPLIENMLDMPPKGGRNWVHYTKQRDLYGPITSLTALGTTVI
LLHDYNLAEEFLSKRAVIASDRPRPFFLTQMHLTIIRCGWGKNIGFIPYDRRLRAMRKQIHALLGTQTALADFNPVQDIE
TRRFLLRVLRKPDQFLKYIKSHRNCSEAAGIMLKTVYGYETNSEGSDPIIFIVEKALEQTSVAGQPGAWLVDYFPALRHL
PDWLPGTGFKRIAKEISRTQNEFSGRPWAFVKYQMAAGKYETSFSSRLLERGEGKLSDEDEYIAKFAANGLYGGGADT
(0)
TVASIMTFFLTMIKYPEFRNKAQAEIDHVVGQDRLPELSDRENLPYTEAVIKEIFRWHTIVPEGL
PHLSSEDCEFEGYFIPKGSILVPNIWAFAHDPSIYHDPTTFNPNRFLGDPPEMDPRTFIFGFGRRICPGKLLADSSVFLT
IARALAVFEILPPLDDQDPNFDPEPGFVSHPAAFQARIMPRTEKDRERILEVERTDPFGRGGEEDMERVVVW
>CYP621A1 Fusarium graminearum FG05113.1
AACM01000205 FGcontig1.205_scaffold3
I propose a 1 nucleotide MICRO exon agggt for
the joint At PK/G/TVV
This is needed to preserve the length and seq in
this joint
The phase (1) and phase (2) boundaries do not
fit otherwise.
MIELYSFAHMLGPALVFTSLLIFWAHTHFQPTLPLPPGPPSEFLLGHTRV
IPKENAAEVYSRWAKEYSQSTIVXXXXXXXXXLHSAEVAKDILEKKGANFCDRPRFTLL
EVMGWGKTLTFLPFGKSWQMHRKFLQTSFSNTNVRQWYNLQMTETHRTVK
GIMARPDTWETSLRRFAVAIVLQVSYGMEVPSDDDPYIRIANDAMYATGN
GGVPANSLVDLVPFDWLINDWSLRFARQWRWAITKLHDVPFAAAQAER
(0?)
CNNKYPANTSLAHQ
LLQSYEHNELQGNKQDWSLDDIKGAAGAVFIAGADTTWATCVIFVLNMVLHP
EIQKKAQDELDAVLRPGKLPEFSDRPSLPYVEHIVQEIYRWSPLAPLGIP
HKSLHDDVYHGMFIPK (1)
G (2)
TVVYANSYAIAHDERVYKSPHE
FNPDRYGAGEPYPVGNFGFGRRICVGRFLAGNSVWIMVATMLSTLQFCKK
VAQDGTPIEPRVQFTNGGTCHPEHFDCVIKPRNATATALINAS*
>CYP621A2 Nectria haematococca
e_gw1.5.1476.1
Necha1/scaffold_5:782235-784633
I propose a 1 nucleotide MICRO exon agggt for
the joint At PK/G/TVV
This is needed to preserve the length and seq in
this joint
The phase (1) and phase (2) boundaries do not
fit otherwise.
MEFTTAKALIELAIVLAVMWFALVHRRTQPTLPLPPGPPAEFLLGHTRLIPKENTAATYARWSREY
(1)
DSDIIHVKSLGRSIVVLNSVEAARDVLEKKGANFCDRPRFTLLEV (2)
MGWGKTLTFLPYGRRWQMHRRLLQTSFSNTNVRQWHKLQITEARRTVRNMMGKPSSWETSLRRLAVAIVL
QVSYGTEVPKDDDPYIQIANNAMYATGNGGAPANSIVDLIPL (1)
ARHLPDWIVRDWSLRFARQWRWAIQKLHDVPFAAAQSEH (0)
KLTFDKDGCSDNKSLAHELLRQYRRNEENGQEQEWSLDDIKGAAGAVFIAGADT
(0)
TWATCVIFILNMVLHPEIQEKARSQLDSVIGPDRLPNFSDRASLPYIEHIVQEIYR
(2)
WSPLAPL (1)
GIPHKSLQDDVYQGMFIPK (1)
G (2)
TVVYANAHAMAHDERIYRAPHDFNPDRYEPLVNGGAGEPFPVGNFGFGRR
(2)
VCVGRFLADNSVWIMVATMLATLEFRKKMGPDGSPIEPRVQFTNGGTC
(2)
HPEHFECDIRPRSHKAAELIGANHD*
>CYP621A3 Gibberella moniliformis
AAIM01001458 79% to e_gw1.5.1476.1
Also Fusarium verticillioides FVEG_06100, one
stop codon
I propose a 1 nucleotide MICRO exon agggt for
the joint At PK/G/TVV
This is needed to preserve the length and seq in
this joint
The phase (1) and phase (2) boundaries do not
fit otherwise.
5016
MIEHYLSQALIGLTLAIATVLLFALAHWRSRPTLPLPPGPPSEFLLGHSRVIPKENAAAVYAKWSKEY 5219
5279 DSDIIHVRSLGRSTVVLNSADVARDILDKKGANFCDRPRFTLLEV 5413
5490 MGWGKTLTFLPFGQRWQMHRKFLQTSFSNTNVRRWHTLQITEARRTIQNILKKPETWETS
5669
5670 LRRLAVAIVLQVSYGTQVLEDDDPYIQIANDAMYATGNGGVPANSIVDLVPF
5825
5889 VRYLPDCIVRDWSLRFARQWRWAIKKLHDVPFAAAQAEN (0) 6005
HRYDYYTNTSLAHH
6132 LLREYKDKESRGQEQQWSLDDIKGAAGAVFIAGTDT 6239
6294 TWATCVIFILNMVLHPEIQEKAQQELDAVIGSDRLPDFSDRPALVYIEHIVQEIYR
6461
6522 WSPLAPL 6542
6601 GIPHKSLHDDIYKGMLIPK (1)6657
6775 G (2)
6790 TVVYANAYAIAHDERVYKNPHNFNPDRYEAGEPFPVGNFGFGRR (2) 6921
6995
VCVGRFLADNSVWIMVATMLSVLRFCKKMSSDGKPIEPRVQFTNGGTC(2)7135
7273 HPEHFDCVIRPRSLATEALVNSD* 7344
>CYP621A3 Fusarium oxysporum (temp CYP621A4)
Also Fusarium verticillioides FVEG_06100, one
stop codon
I propose a 1 nucleotide MICRO exon agggt for
the joint At PK/G/TVV
This is needed to preserve the length and seq in
this joint
The phase (1) and phase (2) boundaries do not
fit otherwise.
93% to CYP621A3 Gibberella moniliformis
FOXG_08569
MIEHYPSQALFGLTLAIATILLLAWARWRSRPTLPLPPGPPSEFLLGHSRVIPKENAAAVYAKWSKEY
(1)
NSDIIHVRSLSRSTV
VLNSADVARDILDKKGANFCDRPRFTLLKI (2)
MGWGKTLTFLPFGERWQMHR
KLLQTSFSNTNVRQWHSLQITEARRTIRDILKKPKTWETSLRRLAVAIVLQVNYGTQVLEDDDPYIQIANDAMYATGNGGVPANSIVDLVPF
(1)
VRYLPDCIVRDWSLRFARQWRWAIKKLHDVPLAAAQAEY (0)
HRDDHYRNTSLTHLLLREYKDKEFRGQEQQWSLDDIKGAAGAVFIAGADT
(0)
TWATCVIFVLNMVLHPEIQEKAQQELDAVIGTDRLPDFSDRPALVYIEHIVQEIYR
(2)
WSPLAPLGIPHKSLHDDIYKGMLIPK (1)
G (2)
TVVYANAYAMAHDERVYKNPHDFNPDRYE
AGEPFPVGNFGFGRRVCVGRFLADNSVWIMVATMLSVLRFCKKMSSDGKPIEPRVRFTNGGTWYIIS
TVPMACFALTHSLQ
>CYP621B1 Aspergillus clavatus
42% to CYP621A3
ACLA_013420
Supercontig 76: 1359064-1360557 (-) strand no introns
MESLILLVLIILPASVLIYKRLTPRNLPPSPPGDFFLGHLRRIPSSHAEYQYAKWSRTYNSDILSLRMLTRCVIVVNSVD
AAHALLKKPTAADRPRFALYEIMGWGITLTFLRSSSPRFKLHRRLLQRSFSPSMCKDYRPIQMQEIRAAVAQIRSHPETW
EVSLRRFAIAVVMRIGFGMDSAQAGGFVDLATAVEEATGRGGVPGFSVVDAVPALRWIPVCVAKRVGMLWGLVHAQQMRG
AVEEFHNGPWGMMEEKLRAGTGETGSSFLGMHLREGKVGVEDLKGAAGTIAIAGGNTTFATIVVCILNLMLQPGVQARAR
AELDGVLGVDARGLPLRLPTFEDRERLPFLERVIQETTRWAPLSPLGIPHAMSAEESVGGLTIPRG
AVVYANAWAMTHDE
RVYAEPERFDPDRYLRGEPLPEGPFGFGRRVCPGQHLALTGVYIAMATLLATVSWRCPVDEAGREKRPEVQFSDGLSGVP
DRFECEMQARDAESKEVL*
>CYP622A1 Fusarium graminearum FG08187.1
AACM01000329 FGcontig1.329_scaffold5
MDFSQNTTTLGVGDYTPEGAGLVAAGAIILVLSLLVLVSPKEKIPVINKY
PNDWFSIKAQIAFVTNADGLIKQGFAKFQNPFRMITLVGDRLILPEDHFE
WIRRHGPQLDHQPLVRKDFFAGYPGFNGTAAISDPSKLLANVIKKKLVQN
PHVSKLHKSVQRDILAAWP QGCDAWKAVD
WAKDGLNLISRMSASVFVGEE
LSHDETWQQVSTNYGMTVFLAARALRQWPRWLRPLIQWFLPACKSCRAEV
KRAREVLEKNLAKRAAEGKEHDDSITWFSEIAAGKIYDPVAAQLGMSMAA
VVTTSELLKQTVIEICSHDLITPLREEIEAVVHEHGWSPAALTNMRLLDS
VIKETQRMNSAVI
VNLDRQVLSPVTLPNGQYLPKGTALSIYMSRLRNPEV
YENPDTFDAYRYAKLRAQGGKWTYASSATSTSEDHFVFGIGKPICPGRFF
AVAEVKTAIATILLDYDVRLAEGYTPKLMPFGFELFADPGVQLEVKRRS*
>CYP622A2 Fusarium oxysporum
84% to CYP622A1
FOXG_12221
MVQWGVAEPVSGIAILARPSSEPSQPQKIGTVSGRRWSFFLCLDQSKAMDLSKYITPLLAGQYPLGGAVLVAVVAFVLLM
LIAPKDSIPVINKYPNDWFLSKAHMAFITNADGLIKQGFAK (0)
FNKPFRMITLLGDRIVLPADHFEWMRRHGPHLDHQPLVSK (0)
DFFAGYPGFDGTAAISDPSKLLANVIKKKLVQNPHVSKL
HNNVRKDLLAAWPEQSD (1)
DWKAVDWAKDGVSLISRMSASVFVGEELSRDETWQQVSTN
YGMTVFLAARALRAWPRLLRPIVQWFLPACKSCRAEVQRAREVLHKNLAKRAAEDKEHDDSISWFGEIAGGKSYDPVAAQ
LGMSMAAVVTTSELLKQTIIEICAHDLVAPLREEVEAVVAEHGWSPAALTNMRLLDSVIKETQRLNSAVI
(1)
VNLDRQVLSPVTLPNGQYLPKGTAISIYMSQLRNPEVYDNPDTFDAYRYVKLRAQGGKWIYASSATST
SEDHFVFGIGKPICPGRFFAIAEVKTAIATILLDYDVRLAEGYKPKLMPFGFELFADPGVQLEVKRRS*
>CYP623A1 Fusarium graminearum FG02117.1
AACM01000111 FGcontig1.111_scaffold1
METYLLVAIALAVVFLVNHKTSPKVPSTIPRLQDSSPFLPFKLYWRYLTD
CRRLFLEAYQEFTKDGKTCVLPSMGFKDEIHLAHHHTQWAASQPDGVLSP
FEGFREIDKGDWNSGHASYIQDPWQSVVIKKEMGRFLEILASDVDDELKT
AVPEYVKPGPNDEVDVYESMKWIVAQVSSRFTVGL
SLCRDKTYLKDTLEF
ADLFILNSGLLIYTPSLLKPLVGFFITLPTRYNRWKIQKHIQTLYEERTK
RLLNPELYEKSEEPTDNLQMMMKYAIDKHRDQVTLSQISNRLCLANLASF
HQTAVATSNVLINIAA
SNAEFNTIEVIRKEMADVLGENGVFDKASVSKMV
QTDSVLRESMRTHGFGNRAMIRKVVSPGGLKTPDGQTLPNGSTMSILSYP
VHNDPTIYEHPEKFHPFRFSQMRSEGNGANLSFVSTSPTYLPFGHGKHAC
PGRFLVDFEMKMILHHVLKEYDIELLPEHNGVRPESHWITEAVMPPVGVK
LRFKKRVLA*
>CYP623A2 Fusarium oxysporum
82% to CYP623A1
FOXG_04463 revised
MAVYLFVAVFLAAVYLAQYRSSPKLPSNLPRLERNSYLPFKLPWAYLTDCRQLFLEAYQT
(0)
FTKHGKTCVLPSMGFKDEIHLAHHHTQWAASQ
TPDAVLSPIEGFREIDKGDWNSGHANYIQDPWQSIVIKKEMGRFLEILAAAVDDELQYAIPEYIKPGAGDEVDVYE
AMKWIVAQVSSRFTVGLPL (1)
CRDKEYLKDSLAFADLFILNSGLLIYTPSLLKPLIGLLVTLPTRYRRWKIQKHIQPLYEER
TKRLLNPGLYEKGEEPTDNLQMMMRYAISKHGKQVAPSQISDRLCLANLASFHQTAVAISNVLINIAA
SDAEFSTIAVIRKEMADVLAESNGVFDKASVSKMIQTDSILRESMRTHGFGNRAMIRKVV
APGGLKTPDGHTLPNGSTMSILSYPVHQDPEIYEHPKKFYPFRFSKVRTGPDGKDANPTLSFVSTSSTYLPFGHGKHACP
GRFLVDFEMKMILYHVLNRFDIELLPEHNGVRPESQWVTEAVMPPVGVKLRFKKRE*
>CYP623A2 Fusarium verticillioides
93% to CYP623A2 Fusarium oxysporum
MAVYLFVAVFLAAVYLVQHKSFQKLPSSLPRLERHSYLPFKLQWAYLTDCRQLFLEAYQT
(0)
FTKHGKTCVLPSMGFKDEIHLAHHHTQWAASQ-PDAVLSPIEGFREIDKGDWNSGHASYI
QDPWQSIIIKKEMGRFLEILAAAVDDELQYAIPEYIKPGDGDEVDVYEAMKWIVAQVSSR
FTVGLPL (1)
CRNKAYLKDSLAFADLFILNSGLLIYTPSLLKPLIGFLVTLPTRYRRWKIQKHIQPLYEER
TKKLLNPGLYEKGDEPTDNLQMMMRYAIDKHGSQVSPSQISDRLCLANLASFHQTAVAIS
NVLINISASDAEFNTTTIIRKEMADVLAESGGVFDKASVSKMIRTDSILRESMRTHGFGN
RAMIRKVVAPGGLKTPDGHTLPNGSTMSILSYPVHQDPDIYENPEKFYPFRFSDMRTDPD
GKDANPTLSFVSTSSTYLPFGHGKHACPGRFLVDFEMKMILYHVLSRFDIELLPEHNGVR
PESQWVTEAVMPPVGVKLRFKKRE
>CYP623B1 Fusarium graminearum FG09195.1
AACM01000371 FGcontig1.371_scaffold6
MSASVMDLGPELLARLPTLTSPLGIASVAAILLISLFITEKLLSVPYPPS
IPLIREPEGARRFSLRTRWQYLTNCQPMYYEAYHKYLKQGKAVVVPGFGI
RIEVLLPQNQMKWTINQPDEVLDQGLAFAEIDQVSWALGHNRFVVDAWQG
MIVKTEMNRTIEVVANAMKEELREVFDEQFGTDTENWKKIDLTPTIKMII
AQAASRFTVGLPLCRNKEYLQNALDTNELFILNAGLTG
GMPQVFKPFT
GTVFGWLVGSKV
SQLKKWIVPLLKQRVDKIKNHPEEPEPQDLLQMMIKYALRERQDEAENWD
SMTRRVVAQNFGAIHNTQIHVVHLLLNVIGSDAEYNTISVLRDEMDRLLG
SDDTEGWTKAAIQSMTRADSVSRESIRLGTFGTRAVFRKVMTDDFKTQDG
HHLPKGTLLSFNSFQAQTDDELYEDGLKYDPFRFSRIREEAASRGEKAPP
ATFVTTSPEFLTFGHGKHACPGRFLIDFEMKMILAYIVKNYDIKFPDEYE
GKRPPNVWITEANNPPSGTHIMVKRRAQK*
>CYP623B2 Aspergillus nidulans AN3497.1 53%
to 623B1 54 clan
MHIMNAVDSLLGVGLYFLLPAALLYIINTVFFGAVYPRGVPFIRERPGKT
SFSLKTRLAYLTDCESLFREAYHKYLKNGKPVILPGFGVRTELILPVSSL
RWATTQPDSVLSPGEAFVEIDQADYSLGHSRYVVDAWQGMLVKNEMNAVL
ENIVAAMNEELGVAFDRYFGTDEENWRDIDLLEAAKLVVAQAASRFTVGL
SLCRNEKYLNDSFDAIDGCVITAGVVGGCPPVLRPLIGPIAGLKARLANR
RLRKHIEPLYHARMEALKLPIEDQPQDHFQMMLRFAQRERKEELYSLDQI
ATRVTVANFGSMHQTSIQVTNMLLNILASDPEYNTIAVLRDEIDQVLGSD
TAWTKAKVSKMTKADSVARETLRCHSFGGRAVFRKVLVDGVTTDTGLPLP
KGTLFSFLSQPAHVDEETYEDPFKYDPFRFSRVREAANDPAKAGSLSFVS
TGPSYLAFSHGKHACPGRFLVDFELKMIIAYVLKNYDIRFPEEYQGKRPA
NRWVAEAVFPPSGVRVLVKRRRA*
>CYP623B3 Nectria haematococca
e_gw1.12.604.1
Necha1/scaffold_12:172258-173956
MAPLLLDQLPSLTSPLGIVLAGSVTIFVLYLVENLIHVPYPPGIPLIREPEGARRFSLRTRYAYLTDCQALFREAYHD
(0)
YIKKGKPVVIPGFGFRKEVILPQSSMKWVLSQPEEVLDVTKAFAEVNQVKWSLGHEKIAVDA
WQGMLVKSDLNRVLENIVNAMNNELKIVFDEQFGKDTENWKEIDLRSTIQIIVAQAASRFTLGLPL
(1)
CRNKDYLKTSLKINDLLILNAGLTGGLPLVLQPIVGTLLSIPTGIQFRKLKKWFVPVWKGRMEVDPSLPEPQDH
LQMMLRYGQRERPDEINDMDVMTGRLIAHNFGSMHQTQIQVTNLILNVLGSDAEFNTIAILRDEIDRILG
PDEDAQWTKAFVNQMTRADSLCRETLRLGAFGGRANFRKVMTSGFTTEDGIPLPKGLVISFLGQPAQTDD
ETMEDPLKFDPFRFSRMRELAASRDEKVPLVSMVSTSPEFLPFGHGKHACPGRFLIDFELKMILAYMLRN
YDVAFPEEYEGKRPPNVWMAEAVVPPEGVRIRIKRRTRQSSN*
>CYP623B4 Gibberella moniliformis
Genomic seq = AAIM02000051.1 PKS ortholog to
PGL1 starting at 437510
There is a CYP623B4 seq at 468-470k 72% to
623B1
94% to 623B4 Fusarium oxysporum
Also = Fusarium verticillioides FVEG_03709
470403 MPYTAE
470385
LGLLARVVSPLGIASIVVIGVIAIYVIDKLTSVPYPPDIPLIREQKGARRFSLRTRWAYL 470206
470205 TDCQALFYEAYHE
(0) 470167
470120
YLKKGKPVVIPGFGVRIEVLLPHSQMKGVLNQPEDVLDMEQAFAEVDQVRWSLGHEKYV 469944
469943
VDAWQGLVVKYDLNRAIEIIANNMKDELHEVFDEQFGTDTENWRRIDLTKTVKMIVAQAA 469764
469763 SRFTVGLPLC(2)
RNKEYLNLALEMNDLFIMNAGLTGGLPCILQPIT
469584
469583
GTLFGQIVNTKVNKMKKWIMPLLKHRFDRINNHPDEPQPQDQVQMMINYALRHRQHEVND 469404
469403
MESLARRVVAQNFGSIHNTQIQIVNLILNVLGSDAEFNTIATLRDEMDRILGTDDSVNWT 469224
469223
KSGIQAMTRADSVARESIRLCSFGGRAVFRKVMVDDFKTEDGHHVPKGSIISFMGHPAQT 469044
469043
DNEFYEDGLKYDPFRFSRIRETAASRDETAPPVTFVTTSPEFLTFGHGKHACPGRFLIDF 468864
468863
EMKMILAYALRNYDIKLADEYEGKRPPNYWIAEANNPPSGVQIMVKRRERK* 468708
>CYP623B4 Fusarium oxysporum
AAXH01000338.1 cont2.338,
PKS ortholog to PGL1
This is the next contig after cont2.337 which
has a pks seq at the end
About 31kb away
CYP623B5 = 73% to 623B1 probable pigment
modification of pks product
Gene model FOXG_05831
33080
MSSSAELGLLARLPSLASPLGIASIVVIGVIAIYVIEKLIGVPYPPDIPLIREPKGARR 32904
32903 FSLRTRWAYLTDCQALFYEAYHE (0) 32835
32788
YLKKGKPVVIPGFGVRIEVYLPQSQMKGVLNQPEDVLDMEQAFAEVDQVRWSLGHDKYV 32612
32611
VDAWQGLVVKYDLNRAIEIIANNMKDELHEVFDEQFGTDTENWKRIDLTKTVKMIVAQAA 32432
32431 SRFTVGLPL (1) 32405
32355
CRNKEYLQLALETNDLFIMNAGLTGGLPRILQPITGTLFGQIVKTKVNKMKKWIIPLLK 32179
32178
HRFDRINNHPDEPQPQDQVQMMINYALRHRQHEVNDMESLARRVVAQNFGSIHNTQIQVV 31999
31998
NLFLNVLGSDAEFNTIATLRDEMDRILGTDDSVNWTKGGIQAMTRADSVARESIRLCSFG 31819
31818
GRAVFRKVMIDDFKTEDGHHVPKGSIISFMGHPAQTDNELYEDGLKYDPFRFSRVRETAA 31639
31638 NRDEKAPPVTFVTTSPEFLTFGHGKHACPGRFLIDFEMKMILAYALRNYDIKFADEYEGK
31459
31458 RPPNYWIAEANNPPSGVQIMVKRRERT* 31375
>CYP623C1 Beauveria bassiana
AM409327
Chembiochem.
2007 Jan 11;8(3):289-297
Biosynthesis of
the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana.
Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ.
Gene name tens2
MALFQAMSMVAQLGYYEKVAGVLGFLSIALLFWKLNHKPFYPAL
PLAGEPPQRRWFSLSNRLRYYNDCAALFDEAYHTAYAKKGKAVLVPSMGVHTAMIMPE
SAMNWAMSQPDDSLSIKKAFSELNQTKYSLGHGRYWEDPWQLDLVKAHLSSILQNLIP
QLNEELAAAFSKHLGTDAENWKEIELEVIMRRIIAQATSRFIVGLPLCRDDGYLDLSY
KVILGMVTTIWATLPFPDLIRAITGPIASWQTRRNIARIQEYLEPLYQERISILESRD
GPESDPEPQDLFMMMLRFAQKKRPDEYANLGIMTRRVCAANFVAMHQSTVSVTNLILN
IIGSDAEFNTTATLRDEITQVMRGTDAKSWTKDTFTRMRKCDSVAREAMRLNFPLGTR
GSMRAVLKDGLESPEGIKLQKGTTISWLASCAQVDADRFDNPQKFDPFRFSRASKDDD
DDGKSTSSHAKDAFVTTSPQYLPFGHGKHACPGRFMVDLMFKILLAQLLTHYDLGWPE
DYQGKQPPSVWQGELSEPPPGARILVKRRKV
>CYP623D1 Histoplasma capsulatum
45% to CYP623B3
HCB03238.1 model is short at N-term
MLGFWLESPPDHGLNAAG
FLLSVSTIVLIFITYFAYAHASCGGNIPRLREPSGKKHFSLKTRWAYYTDCAGLFNDAYNN
(0)
FSKKGLPVWIPSLGTRNDIL
MPHKDLAWVLAQPPNIISIRHAYNDINGIKRSLGSSKYMLDNWQGMLVSKELNKVLDGIVLSLNDELKYVLESRLGRDTV
NWKVLDLQQTVQMMIVQATSRFHVGKPL (1)
CRNEEYLHLILNIMDEMIFSAAVTGAFPAILQPLINPVASWRLRRLISRVRK
LIEPRFEECMAHDTADDKCTDFFQMLFRFARKERPDELNIWDLTNRLCMANFEAIHQTSMAITNMILNIVSSDAEYDTIS
ILRRETTAHLGCGSGNSREYLDDDTKWTKAKIAKLVKADSIARETMRLHSFANRGLFRKVMADGVQTEDGISLPKGSILS
FLSQPLHTDGDIFGDPLKFDPWRFSRAREQCESATASPATVEAAGTHSLVSTSQLLSFGRGRNACPGRFLVDFEVKMIVS
YLLLKYDIRFPEEYGNQRPQNRWLAEASVIPKDARVMVRRRK*
>CYP623E1 Neosartorya fischeri
51% to CYP623B2, 46% to 623B4
NFIA_042090 revised
Note: this seq does not have an ortholog in A.
fumigatus
MGASTFSQSFAGGYEAWASLMLPALVGCALLIYRAFFAIKYPANLPLAGEPEGKRTFSWRTRWRYYTDCEALYRETYEN
(0)
YTKSGKTVLLPGLGFRNDIVLPQSA
MRDIMARPETELSHADAVLELVQLKYALGHEKYKADPWPCMLVKSDINSKLEAVCDGMNEELKYVFDKYIGCDTESWKEV
DLLETIRTVIMAAASRFTVGFPLCRNEAYLRACWKVNDGIVMNGGLTGATPRLLRPIVGPLITMKLRRSIEQVKKQVEPI
YHQRVQALSQQNSAEKPASEEPQDLFQQMLCYAQRERPGELHDLPSMSRRLCFANFAAVHQTTLLVTNMILNIVSSDSQY
NTISVLRDEVNDVIGPDSDTKWTKYKVAQMIKSDSVARETMRLYSNTNRGVFRKVLVEGVKTEDGIELPKGAYVSFLGRP
LQCDPEAFEDPFEYDPFRFSRIREQAPRDTKGRSSASHLSFVSTSPEHLPFGHGGHSCPGRFLVDFEVKMIVAYLLMNYD
IEFPAEYKGQRPANRWMAEALVPPSGARIRIKRRS*
>CYP623E1 Aspergillus terreus NIH2624
AAJN01000124.1
93% to CYP623E1 = ortholog
ATEG_04418.1
39131
MGASTFSQSFAEGYAAWALMLPALVGCALLIYRAFFAIRYPANLPLAGEPDGKRTFSWR 39307
39308
TRWRYYIDCEALYKETYDN(0)
YTKHGKTVLLPGLGFRHDIVLPQSA 39487
39488
MRDIMARPEKELSHADAVLELVQLKYSLGHEKYKADPWPCMLVKSDINSKLEAVCDGMNE 39667
39668
ELKYAFDKYVGCDTESWKEVDLLETIRMIIMAAASRFTVGFPLC
39845
RSEAYLRACWKVNDGIMMNGGLTGATPRLLRPIVGPLVTMKLRQSIEQVKKHVEPIYRQ 40027
40028
RVQALSQQNSAEKPASDETQDLFQQMLRYAQRERPGELHDLPSMCRRLCFANFAAVHQTT 40207
40208
LLVTNMVLNIVSSDPQHNTISVLRDEVKDVIGPDSNAKWTKYKVAQMIKSDSVARETMRL 40387
40388
YSNTNRGVFRKVLVEGIKTEDGIELPKGAYVSFLGRPLQCDPETFEDPFEYNPFRFSRIR 40567
40568
EQAPRDTKGRSSASHLSFVSTSPEHLPFGHGGHSCPGRFLVDFEVKMIVAYLLMNYDVEF 40747
40748
PAEYKGQRPANRWMAEALMPPSGARIRIKRRS*
40846
>CYP624A1P Fusarium graminearum
AACM01000117.1 Gibberella zeae PH-1 revised
MISDYLQLPKGYEIPILFLTPILLNFVGTILYNVFFHPLAAVPGPLACKV
CRAWLYLAERGGDGANTVAALHKRY (1)
GPLVRIGPNEVSIKDREAFVTINQK
GADF*K
DPAFYDAFSSNHGNLFTFSNVDEYS
KRKRLMSPSFSRASTEKHDAIVHATITPLVEEVALSVRKGESIDLYSVMR
RFAIKSIISFCYGNNSISPDYFESVIPKLFQVLDESPKDLLVLQHFPLLR
KSLTHLATVFPQLFPESIKFLQMVGMELLSSSRKSSSATQPGLFKEMQTL
LKVKDQSLTDDELIAESSTMFFAGTDTTATTVSVALWHLIHQPDDYARLQ
DELRTIMPDVNSGPSLRELESLPFLEACIKESLRLACPVRGRLPRIFPPE
GLEVNGFRIPARTVVSSCISYMTYDEEVFPEPWKFRPGRWLQDNSKDLDG
FLYPFSRGTRSCIGQSLSLAEQRVAISQMVRRFSPRKGMQFREIVGKELF
QTWVNTEKVNQVPVGDDSTR*
>CYP624A2 Fusarium oxysporum
80% to CYP624A1P Fusarium graminearum
FOXG_06966
MLPDYFQLPKKYEILFLFLSPILLSLFGTVLYNVFFHPLATVPGPLACKISRVWLYLAERGGDGANTLAALHKRY
(1)
GPLVRIAPTEVSIKDREAYVTINKQGSRFLK
DLAFYDAFSSNHGNLFTFSNVDEHSKRKRLMSPSFSRASMEEHDTIVHATIKPLVEEVVVSVRKGETVALYSVMRRFAIKSIIAF
CYGNNLISPEYIDNTVIPKLFQVLDKSPKDLLVLQHFPIVRRSLRHLATTFPQLFPEAIRFLQRVGMELLDSSRESSDAS
QPGLFKRMKELLKVKEQSLTDGELIAESSTMFFAGTDTTATTASVALWYLMHQPDNYARLQDELKTVMPDVNSRPSLREL
ESLPFLEACVKESLRLACPIRGRLPRVVPPEGWEVKGVRLPGGTTVSSCISYMTYDEDIFSEPMKFRPGRWLQENSKELD
GYLYPFSRGTRSCIGQSLSLAEQRVAISQIVRRFSPSKDMQFREIIGKEYVTWVMEDELPVQLKEAE
>CYP625A1 Fusarium graminearum FG10991.1
AACM01000457 FGcontig1.457_scaffold8
MPLILSITSSGTVLVLLTLLSLAAVVILSTYRLIKYRHIPGPLLCRVSHH
YVTLFDLLRQRPQTVAKWHRQYGPFVQIAPGQVSISDVTAMRELYSSSAR
NPKSGYFDNFLYHNARAIFAEKEYLGHREKRGLVSSFFQATSVYKPDIQQ
PLRDRVLAAMMRIEENIITSGQGVVDVMPIINHYAWDNTTSLVFGPCHSS
QALQGDENDRNLLARLKNSEMWGAVKNNLPIVFSGIKLAVAVYTRSTKYF
SAEDDLDKWAMQRLYKTTSDPKSSQDERSIVQLIQHLRQNGRPLSDSYLE
SEIIDNLYAGQATVTVALTYAVYHLSRNPYWQSMVQRELDGLPRDADGLP
NWTLLNKAPILEACIRESYRLNPVASGRAERVLARDSRYGDIFIPQNTIV
SASTIALHLDPQVWLNPREFNPRRWLDATPDEILRLERSFIPFGYGARLC
LGKAFANLQIKMFVAAIYSKDNTGLEIPGQTMEQWGTQDALPKGLKCRLR
FEERK*
>CYP626A1 Fusarium graminearum FG11465.1
AACM01000467 FGcontig1.467_scaffold9
MSVTIVSAIAIFFVAIALKLLSNFYYGPLSSLPGPCYTCVTGIPLLYSRA
TGTSREHLRCLHKRYGPVVRVGPTEVSLNSVDGYYKVHGVGSHCIKAPVF
DSIRFSHSPMLFTIRDPKFHAQRKRILGRGLAAMKEGQESKIRRLAELAV
SNIEKEVQEGKSDVYKWWRCLAVDVISEMSFGKPFELLRPGGQDLPVYKA
LGNAGSGVVLQVMLPSFLQSLVRWSPITWLRDIARVGETIFGRVLIALNE
ASLPSCGPSMVRHILGEAELSKSPVLSDEELGSEVSMMLVAGSDSTAATL
TYATWAIIRDPDLRRKIEEEVARLPEHFTMKDLDRLPLLNSTLEETLRLY
NPAGALVERVLPPSGMSIHGWDLPGGTMVYTTGWLISRLEDVFPDPDMFD
ATRFIDPSPEQTRAHVPFSIGSRSCIGMQLARMEILVTLATLFRQCRDMKL
HHGMTDEMM
TQFAPPPPRRSSGGGFLGLSTWQVIALLIILILLLLGIFM
CMRKKSEPKAPEEDEGEEEEEEEEEEEEGDEEAADDDEGEEEPVPDEMQM
NAYNAQYLANPYGNPYAQQPSSATIIGSHAIYTFPRGFAVEWLFIVVNDS
IAKGFQVDNQLSAMDSDPWTDAMPGGDQTGLFGAERARRTQ*
>CYP626A2 Nectria haematococca
fgenesh1_pg.scaffold_58000026
Necha1/scaffold_58:57207-58707
59%
to 626A1 Fusarium graminearum
MSATVILTIVVLALIFLFKILFDYSQSSVSSLPGPWYTRFTDIPFLYARLVGTSRHYLQRLHKIHGSVVR
VGPKDVSINSIDGYYKIHGVGSHCTKTPVFDKIRFSHSPMLFTMRDPQAHAQRKRILGRSLTAVRADQET
TIRRLVELAISQIKTEAEDGRVDVYKWWRCLAVDVMTEMAFGQSFDLLESGGQDSPVSKALEKVNMKVML
QAILPEALMSPLRWSPITWVRDVVCCTEVMFGHVMAALGELRHSPKCATTMLGRILSEDNIKSRRAALDD
DEMGSEAAMMIVAGSDSTAATLTYAVWEVLRHPVLRQQVEDEVAALPLGFTAKEVEALPLLSNVLEEVLR
LYNPTGAPVERSVPPGGISVDGWDIPGGTTVYTQSWLLSRLEGVFPQPEK
(2)
FDANRFANPSPELKRAHVPF
SIGSRSCLGMNLARMEIRLALALFFRECRGARLHHSMTDDMMTQVGEFFIVPKAGRCDISVP*
>CYP626A3 Fusarium oxysporum
67% to CYP626A1 Fusarium graminearum
FOXG_13273
MFLSFIPILSIVLLAFVLRALFNYHRGPLSRLPGPWYTHFTGLPLLYTRAVGTSRQHLRHLHKVHGPVVRVGPKEVSINS
VDGYYKVHGVGSHCLKAPVFDHIRFSHSSMLFTMRDPRIHSERKRIIGRGFSSIKEEQEVKIQRLASQAVANIKKEAEKG
QADVYKWWRCLAVDVVSEMSFGKSFNLLHSGGKGLPLYTALSNAGPSVVFQAVLPRRLISLFKWSPIAWLRDVGQVTETI
FNRVTSALGELRVSSNCGPSIARHLLSQEVKGKKPSLNDDELSSEVSMLLVAGSDSTATTLAYATWQIVRDPDLRKQIEE
EVSNLPTNFTAKDVEGLPLLNSALEEVLRMHNPAAALVERLVPPSGISVHDWDIPGGTMVYTTGWLISRLEDVFPEPDR
(2)
FDATRFLNPTPEMKRAHVPFNIGARRCVGMHVARMEILVTLAMLFRECRGLQLHHGMTDEMMTQVGEFFIVPRAGRCDLSV
>CYP626A3 Fusarium verticillioides
90% to CYP626A3 Fusarium oxysporum = ortholog
FVEG_12256
MFLSLIPILSIVLLAFVLRAAFNYYRGPLSPLPGPWYTHFTGLPLLYTRA
VGTSRQHLRHIHKVHGPVVRVGPKEVSINSVDGYYKVHGVGSHCLKAPVF
DHIRFSHSSMLFTMRDPRIHSERKRIIGRGFASMKEEQEVKIQRLASKAV
ANIKNEAEKGQADVYKWWRCLAVDVVSEMSFGKSFNLLHSGGKGLPLYTA
LSNAGPCVVFQAVLPRGLISLFKWSPVTWLRDVGQVSETIFNRVTAALGE
LRSSSNCGPSIARHLLSKEVKGKTPSLNDDELSSEIGMLLVAGSDSTAAT
LTYATWEIVRDPQLRRQIEEEVGSLPVNFTAKDVDILPLLNSVLEEVLRM
YNPAGALVERLVPPSGISVHDWDIPGGIMVYTTGWLVSRLEDVFPEPDR
(2)
FIATRFLNPTPEIKRAHVPFNIGARRCVGMHVARMEILVTLAMLFRECRG
LKLHHGMTNEMMTQVGEFFIVPKAGQCNIGI*
>CYP627A1 Fusarium graminearum FG07804.1
AACM01000320 FGcontig1.320_scaffold4
MWSKPLPGHLAQVADSLPPEVTEALSNLTWTQGFVAFVALFIIVPRVFEL
LRNILSPVSRIPGPLINKLSPWPLEIATFKGKSHRFARALHQKYGPIVVL
APNMISVGDANEIKRIIQNEDWVKCEAIYGNFRQDPHRPTLLAFTEKKAY
SRRKRMLSSMFGIRYIRSLEPLMKSCVDAGVAHLDKLCENSNNSTVINLQ
HFIHGLAIDTIGATTFGGSFNVVENGSHPLPSRLKAGMKISAVMQLISWI
KYIPFLPKRDPYIEEFTFNIVDKRRKESGDVKHQDLLQHLVDVSDDSPSS
EFRTSDVQDESVILLAAGSETTANAELFTIMQLLKHPNIMKKLVEEVDKW
YPPSEPDRDTECAYSQAGMTYLQACIDETMRLIPGQATGSPRDASKQETV
LGYRIPKGTTVFPNTQEAHLNPDNWENPDQFIPERWLDIYSQNQTSSVPY
WPFSAGSRVCVGKHFAFQEMHISLTTLLRKFSFEYVPGQDETTVFRIAQQ
LQANSYDVKVKRRFV*
>CYP627A2 Fusarium sporotrichioides
GenEMBL
AY226098
Brown,D.W.,
Proctor,R.H., Dyer,R.B. and Plattner,R.D.
Characterization of a fusarium 2-gene cluster involved in
trichothecene C-8 modification
J. Agric. Food Chem. 51 (27),
7936-7944 (2003)
gene="P450B"
94% to
CYP627A1
MWSSKPLHDNLAQVASSFPPEVSETLSNLTLTQGFLAFLVLFII
VPRVFELLRNIFSPVSRIPGPLINKLSPWPLEIATFKGKSHLFARALHQKYGPIVVLA
PNMISVGDANEIKRIIQNEDWVKSEAIYGNFRQDPHRPTLLAFTEKKAYSRRKRMLSS
MFGIRYIRSLEPLMKSCVDAGVAHLDKLCENSNNSTVINLQHFIHGLAIDTIGATTFG
GSFNVVENGSHPLPSRLKAGMKISAVMQLISWIKYIPFLPKRDPYIEEFTFKIVDKRR
KESGDVKHQDLLQHLVDVSDDSPGSEFRTSDVQDESVILLAAGSETTANAELFTIMQL
LKHPHVMKKLVEEVDKWYPPSEPDRETECAYSQAGMTYLQACIDETMRLIPGQATGSP
RDASKQETVLGYGIPKGTTVFPNTQEAHLDSDNWKNPDKFVPERWLDIYSQNQTSSVP
YWPFSAGSRVCVGKHFAFQEMHISLTTLLRKFSFEYVPGQDETTVFRIAQQLQANSYD
VKVKRRSV
>CYP627A3 Nectria haematococca
e_gw1.8.77.1
Necha1/scaffold_8:382363-383945
MASQPSPIVGRLKLPESMPSLVSLEELTATKVLVTFLTIVIIVPRVFT
(0)
VIKNAFSPISSIPGPLLNKLSPWPLTIATIKGTS (2)
HHFARSLHEKYGPIVVLAPGMIAVADTKEIKRIIQTEDWTKSEAIYGNFRQDPQRPTLLAYTDKKAYSKRKRMLS
SMFGIKYIRSMEPIMMTCVEAAVRQLNKFCDEGSQGAAVVDMQHLIHSLAIDVIGITTFGGSLHVVDNGS
HPLPSRLKAGLRIAGLMQLIPWIRFIPFLPTRDPYVDKFTYDIVDGRRQELESSQHSDLLQKLVEASDDS
PGSDFRTSDVQDESVVMLTAGSETTANAELFTLMMLLKNPEVMNKLVDEVDQWYPPSEPDRQTDCGYSQA
GMAYLQACIDETMRLVPGQATGSPRETSKDDVVLGYRIPAGTTVFPNTQESHMQDAHWEEPQKFVPERWL
EAQAANMPYWPFSAGSRVCIGKHFAFQEMHLTLVTLLRKFKFEYVDGQDESTVFRVAQQLKAESYRMKVSKR*
>CYP627A4 Fusarium verticillioides
83% to CYP627A2 Fusarium sporotrichioides
FVEG_11079 not found in the F. oxysporum
genome
MESTPLQYPLGLKTDSLVKQVSEVLKSLTVTKAVGAFIVLFIIIPKVF
DFLRNLFSPVTSIPGPLINKFSPWPLEIATFKGKSHRFARALHRKYGPIVVL
APGMISIGDSKEIKRIIQSEDWVKSEAIYGNFRQDFHRPTLLAFTEKKAYS
RRKRMLSSMFGIRYIRSLEPLMKSCVDAGVAHLNKLCDNPSKSTIINLQ
HFIHGLAIDTIGVTTFGGSFHVVENGSHPLPSRLKAGMKISAVMQLISW
IKYIPFLPKRDPYIEKFTFDIVDKRRKEAGAVKHQDLLQHLVDVCDDSPGS
EFRTSDVQDESVILLAAGSETTANAELFTVIQLLKHPEKMKKLIAEVDKW
YPPSEPDRATECAYSQTGMTYLQACIDETMRLIPGQATGSPREASKQEVL
LGYKIPRGTTVFPNTQEAHLDGSIWEQPEKYIPERWLEIYSRNQTSAMPY
WPFSAGSRICVGKNFAFQEMHISLTTLLRKFTFEYVPGQDETTVFRIAQQ
LEADSYKVRVKKRF*
>CYP628A1 Fusarium graminearum FG03086.1
AACM01000147 FGcontig1.147_scaffold2
MAGPQAYSPSDEQCEVMEPPTMTFSSISLDSAESLAILFFLGVASHVLAF
RKGEWDMWTMPFICTWITYQAVTPCALNQLRHMAYFDAMILANKWLFSFL
FGMTSSILIYRGFFHRLNKFPGPFVARLSNVYASWLAIKEEHMYLEVQKL
HQKYGDIVRIGPQELSIATPSAFRILHANNSPIVKGPFYNVARPCVNLLA
DRNKKSHAQRRKTWDKAFTAKALRDYEPRVVRYTKQLTEQIEKTKGNPIN
IGAWINFYTFDIVGDLAFGTSFNYLVNGVKDKFLRDSHDSQVLMGYFRQC
TWLFEVFKETPLLNNSWLSFQSWLKQKVEARRQNKPSEPDVLSWILEEYD
SIENPTKDDYLRLCGDAHLIAVAGSDTTSAATSILLHQLTLHPHVLKKLQ
AEIDEYQANYEKPDHFSMTKLQYLQACIDESLRLHPVIMSGLQRMTPPEG
MQIDDVFIPGDTIFHAPSYTIYRDERCFVRPLEFIPERWTTQPELIIDSS
VYAPFSTGRGACAGKQLGLMEMRYVLTEILSKYNMSFAPGTNPEAFIDGL
RDCFTLELPELNMIFTPRGEKSHQTVPY*
>CYP628A2 Nectria haematococca
e_gw1.35.73.1
Necha1/scaffold_35:40906-42850
53% to 628A1 F.gram. GKMILTMLL seems long
MDLLDPFKSYCVVFLVGVLLHVVFFCRGEWDIYTNKIVVAWVGTLAASTFLIAESAEYESDSHSEAFTIA
LKHCSTLAAGTICSILIYRAAFHRLNVFPGPFKARLSNLYVTALGLKKRHLYKEVQELHRKYGDIVRI(1)
GPSEISINSSEALHALHSNNTPCIKGPWYNIIYPMVSLLADRNKKSHTERRKTWDKAFNAK
(1)
ALRDYETRVVQYVGLLLHQLEKMEGQPFNAKLWIHYYTFDIMGDLAFGQSFGMLRDGLKHYYMKLGDENMSL
IGAFSRLIWLFPLFKAIPGVNYTHLKFQRWLREQVDRRRKASEFRL
(0)
PPVSDVFSWILEDYESKDQPTKQDFLNLHGDAHLIVVAGS (2)
DTTAVTTTSLFYELSQRLDICSQLQEEIDEYKKEHKKSDYASLSHLKLLQACID
ETLRLHPVVPSGLQRMTPPEGLQIGDTFIPGDTIVQVPSYTLQR (1)
DERVFLRPNEFLPERWTSQPDLVKDASAFAPFSM (1)
GRNSCVGKQLGLMEIRYVTTEILSRYDIQFAPGNDPKAYLENKMDVFTAAVPDLNLVFTPRI*
>CYP628A3P Fusarium oxysporum
51% to 628A2, 48% to 628M1, pseudogene
FOXG_10725
MHPTSLAIGTGLSSGILAHILIFSKGEWDLYTIKIL
QGLLIVIVLLALSFKRLGTTEAGSPYQRLRI &
TIASIYMVSLMVLGTFCNIFLYRICFFHRL*QFPGPLMAKVSNLYLTRRSVARFQLYKEI
QNLHRTYGDIVR (0)
(1) VGPSALSILDAKAFHAIHANNSPCRKGPWYNIEQPA
ISLHMTRDKNDHSRRRRAWDRAFSSK ()
ALRDYEPRVVKYTSQLLNRLEQSQATTIDIAKWFKFYSFDTMGDLAFGQSFNMLTDGVKH
PFMALVESHMAMAGTFSQLIWMFPLFRAMPFLGREDAIFQKWIGNQVRHQEQ
(0)
NEPDLPNIFSWLLEDYKSQLYPKEQDWLSLQADMQLIAVAG
SDTTSVTLTCLFYLLATNKNACMRLQEEIDNLFSSSSQPNHSSFSKLTYLQTCIDETLRL
FPPVPSGLQRMTPAEGLQVGEIVIPGGTIVTVPSYTVYR ()
DERYFTAPNDFVPERWMIKPEMVKDDSVFAPFSV
GRYACVGKQLGLMEVGYATCMILHRFNICLFGEGTITKPAFLKGLRDHFTLNAPELNVILTARKH*
>CYP628A3P Fusarium verticillioides
83% to CYP628A3P Fusarium oxysporum
no gene model
MYPTSLAIGTGASSGVLAHLLIFRKGEWDLYTIKILQGLLMVFGLLALSFRRLGATEDGSPYSLLDPS
&
IASIYMVSFMVSGAFCSIFIYRISFFHRLYKFPGPFMARAFNLYLTKRSVASFQLYREIQDLHRRYGDIVR
(0)
GPSALSILDAKVFHAIHSNTSPCSKGPWYN
IEQPAISLHMSRDKNDHARRRRAWDRAFSSK ()
ALRDYEPRVVK
YTSQLLDRLVQTQDIPIDIAKWFKFYSFDTMGDLAFGESFNMLTGGVKHPFMALVESHMA
MAGSFSQLIWMFPLFRAMPFLGRADAIFQKWLENQVRHQEQ (0)
NKPDLPNIFSWLLEGYKSQIHPKERDWLNLQADMQLIAVAG ()
DTTSVTLTCLFFLLATNKDACVRLQEEIDNLFSSFSQPNHSSFSNLTYLQACIDETLRLF
PPVPSGLQRMTPAEGLRVGDIFIPGDTIVTVPSYTLYR ()
DERYFTSPDDFVPERWTTKPEMVKNESVFAPFSV
GRYACVGKQLGLMEVGYATCMILNRFDIFLSGEGPTSKSAFLKGLRDHFTLDALQLKIVLTARK
>CYP628A4 Fusarium oxysporum
62% to CYP628A1
FOXG_12115
MLWTEAHLETPQAFGAAFLLGVLVHVFVLRKGEWDL
WTVKLIKAWATYEVTVSLFLAQLYSLSVWQALSVTNKWFASFATGLTISILVYRAFFHRLN
RFPGPFLARLSAFYPTYLVVDEEHMYLEVQKLHEKYGDIVRI (1)
GPTEISIATPSSFRVIHATASPVTKSPFYGISHPWTNLLAERRKRQHANRRKAWDRAFTTK
(1)
AIALKDYEHRVLKYTKLLTDRIDDMKGKPFNVSLWVNFYTFDIMGDLAFGKS
FNMLENGVEHKFFTESHKSQGLLGAFRRLIWFFPLVTAIPIINSSYLSFQAFIRNQVETRRK
(0)
DTPEEPDVFTCILEDYDAIEKPTEQDYNNLCGDAHLIVIAGS (2)
DTTSSSTTCLLHNLALHPDVLAKLQAEIDDYKNTHEESDLISLGKLQYL
QACIDESLRLYPVVPSGLPRMTPPEGMMEIDGVYIPGDTILHNPSYTMYR
(1)
DERCFEKPNEFIPERWTTKPELIKDASVYAPFST ()
GRGVCAGKQLGLMEMRYVLMDILSRYDIAFAPGTNPQAFIDGLRDCYTLELPRLDMVFTPRASENGKA*
>CYP628A4 Fusarium verticillioides
86% to CYP628A4 Fusarium oxysporum = ortholog
FVEG_10685, FVEG_10685 join
MLLTEAHLETRQAFGAAFMLGVLVHIFILRKGEWDLWTVKLIKAWATYEVTVSLFLTQLYSF
SVWQALSVTNKWFTSFVTGLSISILTYRAFFHRLNRFP
GPFLARLSTFYATYLTVDEEHMYLEVQKLHEKYGDIVRIGPTELSIATPSSFRPIH
APSSPVIKSPFYGITHPCVMLLSERRKKEHALRRKSWDRAFTTK
ALRDYEHRVLKYTKLLNDRIDEAKGEPFNIALWVNFYTFDIMGDLAFGKSFDMLESGV
EHNFFTESHKTQGFMGAFRRLVWFFPLVSSIPIVNSSFLAFQ
AYIRNQVETRRKNKPAEPDVFSSILEDYDAMEKPTQQDFDNLCGDAHLIVIAGS
(2)
DTTSSSTTCLLHNLVLHPDVLAKLQAEIDEYKNTHDEYDLVSLSKLQYLQACIDESLRLY
PVVPSGVPRMTPPEGMQLDGVYIPGDTIIHSPSYTMYR (1)
DERCFEKPNEFIPERWTTKPELIKDASAYAPFHT (1)
GRGVCAGKQLGLMEMRYVLMDILSRYDIAFTPG
TNPQAFIDGLRDCYTLELPRLDMVFTPRTGGNAKA*
>CYP628B1 AAIM01002625.1 Gibberella moniliformis 7600
47% to 628A1
same contig as CYP5055A2 about 16kb apart
also Fusarium verticillioides FVEG_04308
7029
MITLSNIQLESLSALCCVALCGVATHLAIFRIGEWDVAVHRIIASFSLIYASIFGLLAYYGDFERQ
6851
SLLNAWYIASELLAAFIAGLYGSMVLYRFFFHPLRQFPGPTFAPLSALCAISMSMKKFHM 6672
6671
FLEVQKLHKTYGDFIRL (1) 6618
6558
GPSEISVASPSAVATIYQNSSPCKKGPWYNVFVPTISLHATRDRQEHTLRRKVWDRGL SAK (1) 6376
AMRDYEPRIEKYTGLLMNQLQQRCGRPVDITDWCGFYGF 6205
6204 DVMGDLAFGKSFNMLNDGVKHYYMELTQMSTLWGSPIGRASWLYLLVKDIPILNRQIVQFLK
6019
6018
WLRKHVDQRTK (0) 5986
5933
NEPHLPDLFSWLLGAYKEQSVHTKQDDLNLLGDAHLIVVAGS (2)
5756
DTTSTTMTCALFELARHPQVYQKLQNEVDEFMKQGDSPHSHSALAKLKYLQAIIDETMRL 5577
5576
YPAIPSGLQRITPPQGLQIDGTFIPGNTIIQTPTYTLNR (1)
DERCFVRPNDFIPERWTTQPDLVRDASAFAPFSI
(1)
GRYSCAGKQLGLLE 5217
5216
VRHVLAQIASKFNIRLAPNQTVEAFQEGLADGFTLLCPKLEMVFEARVS* 5067
>CYP628B1 Fusarium oxysporum (temp CYP628B2)
80% to CYP628B1
FOXG_17440 REVISED
MMNLSAIQLDSFPVLVVVAFCGVATHLAIFRIGEWDVAVHRIIAFFGLIY
AFIFTLIAYHRDLDHQSLLSAWYTASALLATFIAGIYGSMVIFRFFFHALRRFPGPTFAP
ISSLYAVSMSMKKFHMFSEMQKLHNTYGDFVRL (1)
GPSEMSIASPSAVAAIYQNSSPCLKGPWYNVFVPSISLHASRDKQEHAHRRKVWDRGLSAK
(1)
AMRDYEPRVEKYTHLLISQLQKRCGKPVDITEWCNFYGFDVM
GDLAFGKSFNMLNDGVRHYYMDLTQTSTLWGTQIARSSWLYLLIKSIPILNYQIANFLKW
LRTHVDQRAK (0)
NEPDLPDLFSWLLGAYREQSVHTKQDELNLLGDAHLIVVAGS (2)
DTTSTSLTCALFELSRHPDVYRKLRTEVDDLLKPEDTHSHSALAKLKYLQAVIDETMRLYPAIPSGLQRITPPQGLQISG
TFIPGNMIVQTPTYTLNRDERCFVRPNNFIPERWTTQPELVRDASAFAPFSIGRYSCAGKQLGLFEIRHVLSHIVSKFDL
RFAPDQTSELFQDGLADGFTLLCPKLEMIFETRKNGELPN*
>CYP628C1 Aspergillus oryzae
GenEMBL
AP007162 also BAE61392.1
47% to
628A1, 45% to 628B1
MDTLWVLAFSSGVATHLLLYRSGEWDIKAPSIVKIYTLLGATLVYLERADLL
DGFPVSTRPKWGIAVILYHIFGVYAS
MLFYRAFWHRLCGFPGPFLARLSNFYVTSLSAKRLHLYEEVQKLHQQYGDYVRL
GPTELS
IADPQAVKALYSGQAKVTKGPWYTVLEPRVSLQMSRDKKEHARRRKVWDQGFSSK
(1) 891591
891531 ALRDYEPRVSHYARQLLEAVR
KNVGKPMDMAKW
FNYYSFDVMGDLSFGKSFNMLAGGQDTYFSTQLHADMKSIGLFSHLTWLFPFFKRIPILNKDYLKFWDWV
GGRVEERIK (0)
891143 NEPDRPDVFSWILDAFQNGPKTKQDHLDLHGDAYLIIVAGS
(2) 891021
890959
DTTAATLTNLFFHLAADHTWQAKLQEELDALPDLTQEKVTNVKLLDALINETLRLH
PAVPSGTQRLTPPEGLQIGDKYIPGDVMVCIPTHTLFRDERAFVRPDEFLPQRWMTQPELVKDASVFIPF
NAGPYSCVGKQLALMELRRVTAEILTRYDVEFAQGQTTEDFLDG
KRDTFTLVTAPLKLVFRER
>CYP628C1 Aspergillus flavus
98% to CYP628C1 Aspergillus oryzae
AFL2G_09748 revised
MDTLWILAFSSGVATHLLLYRSGEWDIKAPRIVKIYTLLGATLVYLERADLLDGFPVSTRPKWGIAVILYHIFGVYASML
FYRAFWHRLCGFPGPFLARLSNFYVTSLSAKRLHLYEEVQKLHQQYGDYVRL
GPTELSIADPQAVKALYSGQAKVTKGPWYTVLEPRVSLQMSRDKKEHARRRKVWDQGFSSK
ALRDYEPRVSHYAKQLLEAVRKNVGKPM
DMAKWFNYYSFDVMGDLSFGKSFNMLAGGQDTYFSTQLHADMKSIGLFSHLTWLFPFFKRIPILNKDYLKFWDWVGGRVE
ERIKNDPDRPDVFSWILDAFQNGPKTKQDHLDLHGDAYLIIVAGSDTTAATLTNLFFHLVVDHTWQAKLQEELDALPELT
QEKVTGVKLLDALINETLRLHPAVPSGTQRLTPPEGLQIGDKYIPGDVMVCIPTHTLFRDERAFVRPDEFLPQRWMTQPE
LVKDASVFIPFNAGPYSCVGKQLALMELRRVTAEILTRYDVEFAQGQTTEDFLDG
KRDTFTLVTAPLKLVFRER*
>CYP628D1 Aspergillus niger
gw1.4.1072.1|Aspni1
36% to CYP628B1, 38% to gw1.13.785.1s, 39% to CYP628C1
C-term is short
ILGITAHLTYFIHADLEKHVVFLVNCLIFWPSLGLIALFILGYRDISQWIGPAILSFHFSLLASIAIYRYFFHALDGFPG
PKLARITALWDFKNTVLNAKWYIKVKEMHGVYGDVVRIKPRELSINDPSAIKDIYGVGTTCVKGPFYDLHYPHRSLQMAR
DKAFHSKRRRLWDRGFTSKXALAGYEPYLLEHCKDIVRVIESRSSQAQEATALIDGFAWDSMGIFAFGKSFNMLHGEPPK
MLQMMRMMGRGASALLSSSWLVILMRGMVGVRRFTDRWLEWCAQCVEERSRVETNRRDLFSYLIEELSSEGDQSIGGVDG
DLVRDSELAITAGSDTAASTLNALFYLLARHPDKLRRLQEEIDTAVPADEELSHAALVKKPYLEGCINESLRLCPAVLSG
LQRETGPEGLRTAGVYIPPGMIVSVPTYTVQRDPRNFPRPNEFIPERWSTQPELVIHKEALNAFSSGTYSCAGKAFAMME
MRLLVSTIVRHFDIEFPPGE
>CYP628E1 Histoplasma capsulatum G217B
ABBT01000077.1 Ajellomyces capsulatus G217B
43% to CYP628D1
C-term seemed too long so removed a possible
intron
HCB02359.1
MLQVVCTAGTLLGIISHLLIFKHGEWERYTPTLTALYAFAIGLLSPAVTLTLTVLSIPSTLLLVSAFWVSYMTGLFGSIG
LYRGWLHPLRDFPGPLAWRLTALWSIKVSVPEFKFPVKVQQLHEEHGDFVRIRPREISINHADAIRDIHGPGTVCVKGPF
YDLNYPFRSLQMLRDKGDHARRRRIWDRGLGIKALTTYEPKILGHCADLINQLIARSRNGKPIEIGPWMNYFGFDVIGDV
AFSKPFDMVKNGKAAQILETFEMSRPIAGSLVCVPWTFILLKRLPVLRDVWSARVKDHSRKVVERMKLGTACKDLFSYLL
DDSPGSPATSAPFVFPEFSVPGDLVCDSELAITAGSDTVAATLTALIYILATHPDKQALLQQELDTLLTGIDDISYQKLS
136153 IPNGSPMLEGVILETLRLYPGAPGGMQRMTPPEGARIAGRWIPGNTLVSTPTYTLHR
(1)
DPRNFEHPTTFIPERWSPAAANLIKHKEAFNPFLIGANSCAGKAMALMELRLVTALIFRAFTVRLHA
(0) 136645
KPGWRDYFTAKPPPFEVLLERRA*
>CYP628F1 Fusarium oxysporum
51% to CYP628C1 Aspergillus oryzae
FOXG_17036
MMMVEPKSFEAIVVSFASGCLLHILFYRKGEWDLLALRIFQAYATLPIIVIGLLRLAEFKGWQHDT
NLSAVSVLLLEGAHILGLLTSILCYRMIFHPLNKFPGPLRARISNFYPTYLTTKNAHLYE
EVEQLHQKYGDFVRL (1)
GPTQLSIIHPKAIDAIYSAKSPCTKGPFYNILHPRVSLHMIRDHKEHSNRRKIWDRALSSK
(1)
SLRDYEPRVTKYTTQLLDRLNEMQGTTINASNWLNFYSFDVMGDLAFGKSFNMLRDGVN
HYFLSSLHDSMKMVGALAHISWIIPILKLIPAVSAEDRKFWAWIESQVEERSR
(0)
MKPDNPDVFAWILDEYERSPKTHQAKLNVEAEAYLIAVAGS (2)
DTTSATLAGLLFELATNPSQIIKLRDEIDMYFSDREHADHTSLSNLIHLNAVIDESLRLHPPVPSGLQRVTPPQGLMVGDTFIPGNTIVQVPMHTVQR
(1)
DERYFVRPSEYIPERWTTSPELVKDKTVYAPFSI (1)
GRYSCVGKQLGLMEVRYVIAHIVRAFDVRLGEGQTQEGFLKSKMDTFTLATPNLHLVFTPRLTK*
>CYP628F1 Fusarium verticillioides
91% to CYP628F1 Fusarium oxysporum = ortholog
FVEG_13835
MMVEPKSPEALAVSFASGCLLHILFYRRGEWDSLALRIFQTYATLPIIVIGLL
RLAEFQGWQHGNNLSAASVLLLEGAHILGLMTSILCYRTVFHPLNKFP
GPLSARISNFYPTYLTTKNTHLYEEVEQLHQQYGDFVRL
GPTQLSITHPKAIEAIYSAKSPCTKGPFYNILNPRISLHMIRDHKEHSTRRKIWDRALSSK
(1)
SLRDYEPRVTKYTTQLLDRLNEMQCTTINASDWLNFYSFDVMGDLAFGKSFNMLRD
GVNHYFLSSLHGSMKMVGALAHISWVIPILKLIPAVNSEDRQFWAWISGQVEERSRMKP
DNPDVFAWILEEYERNPKTYQAKLNVEAEAYLIAVAGSDTT
AATLTGLLFELATNPSQIIKLREEIDQYFMDREHADHTSLSNLIHLNAVIDE
SLRLHPPVPSGLQRVTPPQGLMVGDTFIPGNTIVQVPMHTIQR
(1)
DERNFARPSEFIPERWTTSPELTKDKGVYAPFSI ()
GRYSCVGKQLGLMEVRYVIAHIIRAFDVRLGEGQTPE
GFLQAKMDTFTLATPNLHLVFTPRPTK*
>CYP628G1 Fusarium
oxysporum
no gene model
66% to CYP628G1, 47% to CYP628F1
upstream = NmrA family
transcriptional regulator
MTTLYNPINLAYHGIAFALGVILHLSVFRRGEWNIHALSILQYFAIFEGIFT
CALRLFLGSEKCTTWTVIPIALTATLSTLVGLFTSMLIYRGFFHPL
KGYPGPFFSRFSSLYITFQAFKNRRLFEELQLFHKTYGDIVRI
(1)
GPNELSILGPHALQALHSTSSSCTKGPWYSIEHPVTSLQMTRDKEEHTRRRRVWDMAFSSK
(1)
CLRRYEDRVAEYTTQLLQHIEALQDEPLDISMWFNFYSFDVMGDLAFGKSFDMLS
NGTKHPFMELTHSHMLVAGSLSRLAWIFPLLKRISIFNQKTCELEERIKQLVDWRIK
(0)
NEPDVPDIFSWILRDYFGLSKLTGQETLNLYGDAQLIAVAGR (?)
SDTTAASLTCLFFELAINPQALHNVQEEIDRYHLEYSTLDHQNLSKLSYLQACINESMRL
YPLLPSSLQRITPPEGLQVGSIRLPGDTIVSIPSYAFNR ()
DERLFKNADQFIPECWTTMTELTRDSSLFTPFSI (1)
GKYSCVGRQLGLMEIRFVASQILRVFDVKLANCNTAKEFASGLRDSFTLA
CPSLHLVFTRRDIWTPSPISEK*
>CYP628G1 Fusarium verticillioides (temp
CYP628G2)
66% to CYP628G1, 51% to CYP628A3P Fusarium oxysporum
FVEG_05671
MAALHAHPYPAYYCLSFVL
GVLAHLFVFRRGEWNLYVFNILQAFAVLESILVYIVARAVEGGDSPVWKVTAISSCFTLS
ALMGSSISMLIYRGWCHRLSRFPGPFYAKLSNFYITFHAFKRFRLFEEVQQLHRKYGDIVRI
(1)
GPSELSIIGPRALQALHSNSSPCTKGPWYSIEHPIKALQMTRDKEEHAYRRKAWDMAFSSK
()
ALREYEARVAGYTTQLVEQIEASQGTPIDASSWFNFYSFDVMG
DLAFGRSFDMLKNGTSHPFMELVHSNMLMAGSLTHLPWIFPLLKRIPVLNRKNLEFQGWL
KQQVDWRHK (0)
NKPDLPDVFSWILSDYDALNKPTAQDTINLRGDAQLIAVAGR (2)
SDATAASLACLFFELAANPEACLHLQRELDQYY
ADHGKPDHSTLSKLRYLQACINESMRLYPAIPSGLQRMTPPEGLDVGSTHLPGDTVVTIPTYTFNR
DERLFTHADKFIPERWTTKKELTKDPSLFVPFSI (1)
GQYSCVGKQLGLMEIRFVASQILLKFNVELTHQDVARDFVAGLRDGFTLAMSSLHLVFTRRTT*
>CYP628H1 Aspergillus terreus
46% to CYP628A2
ATEG_08441.1
MLISLDGSCILAAAYILGIGLHQTIFRYGEWDLHSFKILVAFSVVPIFLGTFLQSFHLPSRGKTTWESLEYSSVLVFIAI
CGIFSSISVYRGWFHRLNEFPGPFLARFSTFYMTFVNIAEARGFKTTQALHSKYGDIVRVGPRELSVANPEAFRAIHLSS
SCGRGPWYNVTAPMISLQMERDVKRHGERRRAWDKAFDNR (1)
ALGDYMTRVNAHTENF
CAAIEDSVKNNTSLNVTKWIHLYSFDIMGDLAFGSSFDMLQSGTFHYFFNLTHKTLELIAIFSRLVWLFPVVKAVPFLSN
DYKSFRKWVGSHVQRRIAVPPPVRDIFSWILNDYQRKQNPSWQDTENLYGDASLIVIAGSDTVAGTLICLLYHLASSPDV
CKKLRDELHSCAKERADTELRPDELAKLPYLQACIDETLRLWPAVVDGLQRETPPEGLTIGTEKKSTWIPGNVIIKTPSY
TLCRDPRAFSRPDEFIPERWTTEPELILDASVYAPFSLGRFSCVGKRLAMVMMRRFISSIILRYELEVLFKSAQDAFERQ
VKEYFTLTPPDLQIRFIKGQKG
>CYP629A1 Fusarium graminearum FG11424.1
AACM01000467 FGcontig1.467_scaffold9
AACM02000392.1 Gibberella zeae
missing the C-term
MEAGGIFELRVRLYWFQAFCTSSLKQFRDLERVHIRQCLALRVDLRN
SDIPGPFAASFTRLWHMNHILKGDQNLELIRLHEKLGHFVRVSYDEVSVSHPD
AISKILLSPLHKLTLLEGNWYKIHALPDYRFQSPMSTTDPRKKVKKSRYI
AGAYSVSNVVRSEEHIDRTFEQFLEWMNRYANDKKPIYLDKFISYTTFDV
IGEIVFSKQFGFLEQGIDIGGAIRNSLALNAYVAVAGYFRWINVLLVANS
LVTWMGIMPMGHLFNTTAAVLANREKNHDVRYDAVSYWFYQHSQHPDKLT
IREINTQALAAVGAGSDTVAAGIQSFIYHMIRHPNAWARAQTEVQDATKK
GLCEDNIVSYADVQELPYVQACVKEALRMFGPVPMGLPRIAPRGGLTFGD
RTIPEGTIVSVSPWVIHHSKEYWGEDAHEFNPDRWLKGDAV (0)
176062
FGAGYGSYPGQNVAKIELAKITATLVRDYNIQQVDPKQEWSWKAYFTVVPHSWPVLVEKIR* 176247
>CYP629A2 Histoplasma capsulatum
ABBT01000202.1 Ajellomyces capsulatus G217B
58% to CYP629A1
HCB05376.1
MAGLKEFSGLGGPQLAGLFTVAVLTLCIWRRYLSPI
SDIPGPFAASFTRLWHIHRILKGDQNLELIRLHNQHGHFVRVAPNEVSVSHPDAVRKILGTMLHKDKWYKI
IAFPDGRFENPMSATDPKVKLELSKHLAPAYTLSNLLINEPSVSETIKLLLGWLDKFASSGEPIDLGKYFTFATSDIVGD
AVFSKQFGFLREGRDINNTIANATPQTAYVSVAGYFRWFHVLFLSNPVITWLNITPWGHLIDTAMTAIKERQKNPDARID
AVAHWFRMLNQHPDRMKLHEIHSAAFNAVAAGNETVSSGLQAFVYYMIRHPNAWDRARAEIDAAGLKDPVISYMEAQKLP
FLQACIKETLRIFGPAPMGLPRIAPEGGLTIGDRTIPQGTVVSVSIWVMHYSKEIWGPDAGEFNPDRWLGEDAARLTKYY
IPWGMGYASCPGQHLARIELYKICAALVRDYNIRQVDPKQEWTWKAYFTVVPHNWPCIVEKRNKETTP
>CYP629B1 Fusarium oxysporum
45% to CYP629A1 Fusarium graminearum
FOXG_16432, supercontig_36 275364-279696
region
MIQINSVNSEVLVSWPGFITELALLAFAIAVHRRYFSNLSDIPGPFWASVTRLW
HVWIILEGKQNVRLKALHRKHGQFVRIAPNEVSVCHPDGSTLLLRANLHK
(0)
GDWYSVTAVPDYRFQNPMSTTNPKMKKALSKHFTAGYALSQVLKREPDVDE
NIEHLLRWVEKYAEDRMPMDLDRFITYTTFDNIGSALFSEPIGFIRA
(0)
GRDIDGTLRNNVALSRFAAVAGFFIGPLRILINPLNSWLLLLPMGRLYKTTSVAI
KKRLHNHEAHNDMVAHWLGAQQKSGELSLRKIEAQANVNVGAGAEPVSHVV (2)
SFCIILIQHPRRLALGFVTRIHRRESLKARAMVASVSFHDADNLTYLRACIKEALRVFSP
TTMGLPRVVAKGGINIAGRHFQQGTILSVSSH (2)
AVHSSKDIWGDDADQWNPERWLSGDTKK (2)
QFSAGYMTCPGRHFAWMQICKMAATLLRNYNIRQVNPKNQWRYQANFTALTHSWPVWVEK
REHEGNMHPDIETLPRDRDQF*
>CYP630A1 Fusarium graminearum FG00012.1
AACM01000001 FGcontig1.1_scaffold1
MIVFYSLGAAFAALFVRIFIYPVILYFADPKGLRKFENFSWLSPLTDLRH
CYLSHTGKRSETLAAEHERRGESILRIGPNALSFNHPQAVRDIYGHQTKC
TKDHKETVLAGPHRNLFDVVDKGEHSRKRRLLSAAFATRNLAKWEFKVRY
TTQRLLDAFDPLCTAPLKTNTDPDPEDLTVDFNNWINLWTIEAINYIALS
SKMTLLDTGTDEAMAETTDGTLYPARYRQSQNHSAMVKSVFCWEYELYPW
LRRISKVVPNKWKSYWATSAPWVDVCYHQAKNRLRRYQAGEKLDDFFSCL
MHDKNGVANAVEWGEVVAEISAIIDAGAETTAIALTHLLQLLISHPAQLQ
KLRDEISGVIGEDDVIAPLDKVKDLTYLKACLDEGLRLIPPVSSGLPRRT
PPEGANIMDTWIPGNTSVSMTIWSAHHNEDIYPDAYAFKPERWLDPTERK
RMEPFFIPFSAGARGCIGRNISYLEQQIVVSTLVHRYDFAMPTKDFKVSR
FEAFNLIMGQLPIKIWRR*
>CYP630A2 Nectria haematococca
e_gw1.26.42.1
Necha1/scaffold_26:302810-304387
59% to 630A1 no introns
MLGYIALGVVLALAFAYLIVKPIVVYFLDPKGLRKYPNYALLSGITDFRHCYTSSQGFRSRSLYE
AHKNTGEPILRIGPNSLSFGDTRAVKAIYGHNTKCIKDDNYNVLSGSHRHLFDVVDKPDHSRKRRLLSAA
FAIKNLEKWEYKVAYTAKRLFEAFDKKCTAPLKGSIPDPQDVNLDFSHWVNLWTTEAICYITLSAKMDLL
DTGTDEVPAEKRDGTRYRGRYRDARDQNALAQAVWVWDYNLWPWVKWLTKTIPGKYQKMWDAAKAWDDIY
YHQAAERLRRFEAGEELDDFFSCLMEDKTGSPNNLEWGEIVSEIGAIINAGSDTTAIALTQTLELLIKHP
QHLQHLRQELDSVLEPDEAIAPYDKVKDLPFLKACIDESLRVIPPTSAGLPRRTPSEGAQILDQWIPGDT
SVNMTIYATHRDPKVFPDPETYNPMRWMDPNERRRMEPLFIPFSAGARGCIGRNISYLEQIVVLASLVHR
YDFALPSPDFEMQRVEAFNIICGQLPIKIWRRKIE*
>CYP630A3 Aspergillus oryzae
AP007164.1a
CDS complement(738572..740134) no introns
First P450 of six on this accession
62% to 630A2
MPGIYVLAAAGALALGVGYVVILPIIHYFYDPKGFRKYPNFAPL
AGITDLPYCYLSSCGYRSKDLYEAHKNAPILRIGPNNLSFGRIGAVKDIYGHNTPCIK
DIKYAMTWGSHTHLFDVIDKADHAAKRKRMSSAFAIKNSERWEHKVANVTGRLVKALD
AHCTLPLLPGQTEPQAADVTLDYNKWINLFTIEAINLIALSSTLGLLEKGSDEVTAQR
KDGTTYPARYRKSQDSTAHAQSLFVWDYKYFHWLSRLSKLVPKYRQMWKDGEPWGDVI
YHQAVTRLQRYQSGEKLDDFFSSLMEDKAGHPNNLEWGEIVAEVGAIINAGADTTAIA
LTQVLDILIRHPKYLQRLREEVDSTLDADEVVAPYDKVKNLPFLRACLDEALRLIPPT
SAGLPRRTPPEGAQILNEWIPGDTSVSMTSYSAHRDPEIFPVPEEYNPDRWMDLDNRK
RMEPYFVPFSTGARGCLGRNITYLEQTVVLATLVHRYDFAVPANWKLGRFEAFNLIMG
EMPMKIWRREKA
>CYP630A3 Aspergillus flavus
98% to CYP630A3 Aspergillus oryzae
AFL2G_05913
MTGIYVLAAASALALGVGYVVILPIIYYFYDPKGFRKYPNFAPLAGITDLPYCYLSSCGYRSKDLYEAHKNAPILRIGPN
NLSFGRIGAVKDIYGHNTPCIKDIKYAMTWGSHTHLFDVIDKADHAAKRKRMSSAFAIKNLERWEHKVANVTGRLVKALD
AHCTLPLLPGQTEPQAADVTLDYNKWINLFTIEAINLIALSSTLGLLEKGSDEVTAQRKDGTTYPARYRKSQDSTAHAQS
LFVWDYKYFHWLSRLSKLVPKYRQMWKDGEPWGDVIYHQAVTRLQRYQSGEKLDDFFSSLMEDKAGHPNNLEWGEIVAEV
GAIINAGADTTAIALTQVLDMLIRHPKYLQRLREEVDSTLDADEVVAPYDKVKNLPFLRACLDEALRLIPPTSAGLPRRT
PPEGAQILNEWIPGDTSVSMTSYSAHRDPEIFPDPEEYNPDRWMDLDNRKRMEPYFVPFSTGARGCLGRNITYLEQTVVL
ATLVHRYDFAVPANWKLGRFEAFNLIMGEMPMKIWRREKA*
>CYP630A4 Fusarium oxysporum
FOXG_13427, FOXG_13426 Join models
85% to CYP630A1
Supercontig_19 936278-937336 (-) strand
Supercontig 19: 932834-933337 (-) strand
C-terminal half 3000 bp away with no good
boundary, possible pseudogene
MIGFILLGAGLAALLIRLFIYPIILYFIDPKGLRKYANFSWLSPLTDLRHCYLSHTGTRSETLAAEHDRRDEHILRIGPN
ALSFSHPQAVRDIYGHQTKCTKDHKETVLAGTHRNLFDVVDKGDHSRKRRLLSAAFATRNLEKWEFKVQYTTQRLLDAFD
QRCTGPLKPNTNPDPEDLTVDFNHWINLWTIEAINYIALSSKMTLLETGTDEVLAEKPDGTLYPARYRQAQNAAAMCKSI
FVWEYELYPWLARISKVVPNKWKSYWATSAPWGDICYHQAKDRLRRYEAGEKLDDFFSCLMVNKNGIPNELEWGEIVAET
SAIIDAGAETTAIALTHILQLLISHPKQMQ (?)
KLRDEVAAVMDEDDIIAPFDKVKDLPYLKACLDEGLRLIPPVSSGLPRRTPPEGAKIMNT
WIPGDTSVSMTIWSAHHNEDIYPEPYVFKPERWLNLEERKRMEPFFIPFSAGARGCIGRN
ISYLEQQIVLATLVHRYDFAMPTKDFKVDRFEAFNLIMGKLPVKIWRR*
>CYP630A4 Fusarium verticillioides
96% to CYP630A4 Fusarium oxysporum = ortholog
FVEG_11857
MIGFVLLGAGLAGLFIRLVIYPIILYFIDPKGLRKYANFSWLSPLTDL
RHCYLSHTGTRSETLAAEHDRRGEHILRIGPNALSFSHPQAVRDIYGHQTKC
TKDHKETVLAGTHRNLFDVVDKSDHSRKRRLLSAAFATRNLEKWEFKVQYTT
QRLLDAFDQRCTGPLKPNTNPDPEDLTVDFNHWINLWTIEAINYIALS
SKMTLLETGTDEVIAEKPDGTLYPARYRQAQNAAAMCKSVFVWEYELYPW
LARISKVVPNKWKSYWATSAPWGDICYHQAKDRLRRYEAGEKLDDFFSCL
MVNKNGVPNDLEWGEIVAETSAIIDAGAETTAIALTHILQLLISHPKQMQ
RLRDEVAAVMDEEDVISPFDKVKDLPYLKACLDEGLRLIPPVSSGLPRRT
PPEGAKIMETWIPGDTSVSMTIWSAHHNEDIYPEPYVFKPERWLDLEERK
RMEPFFIPFSAGARGCIGRNISYLEQQIVLATLVHRYEFAMPTKDFTVDR
FEAFNLIMGKLPIKIWRR*
>CYP630B1 Fusarium graminearum
AACM01000338.1 revised
MYAQLVTASTALCLVTYFILYPIFQYLRDAKGLRRYPNFHPLAGVTNLPF
VREAARGFRSKTLYEMHKTHPVIRTGPNSLSYGSVQAIKDIYGHGTKCTK
GEFYETLAGTHYHLADVVDKADHARKRRALSAAYALKNLENWEFKVADKA
ERFIRAADAACTLPLKRGFARPGPEDLKFDYRAFTNFFTLDAIADIGLSE
RLGFLDQGHDLVKGERMDGSIHHVNFRECLHSTARAQSILAWTEKWYNAN
VKLSKLFSKDFRKWWNLNEGWNDIVYHRATQRLERYNKGEKLPDFFQALM
DHSEANPPGLEWGEIVAEVSIMMNAGSDTTAIAMNNVMYWLLKNPSCMAK
LRQEVDSVLDPEEVVAPYDKVKHLPYLRACLDESLRITPPTTFGLPRRTP
PEGWNIMGDYVPGDTTVSISAYVAHRDPHIFPDPESYVPERWLGEKGKDL
QSYFISFSTGARGCI GRNISYLEQTVLLASVVHRYEWALPYAKWEPSRTE
AMNLAPGPMPLKVWRRDLGGDENDEKHG*
>CYP630B2 Aspergillus nidulans AN5837.1 60%
to 630B1 53 clan
revised 7/19/07
MITLTYAAITGLLVLVYFVIWPVFEYFRDPKGLRRYPNMSIFSGISAIP
FMLMASRKFRSKELQELHKKHPVLRTGPNSLSYGDVRAIKDIYGHNTRCG
KDPSYIVSAGSHYHLADVIDRADHSRKRKVLSSAYALKNLETWEHKVSDK
IARLVKHFDSVCTAPLPAGQEEPDPADLTVDFRAWTNFFSLDAIVDIGLS
EKLGFLDQGHDMCTAERKDGTTYRASLRDALYPNARKQSLLLWNYDWYPI
INRWVNIIPYFAKMQKSSDTWEDIVWHHAMQRRRRYEAGEKLEDFFSALM
EDKAGHPLGLEWGEVCAEINIMMNAGSVTTAIAITNVMYQLLRNPQCLAT
LREEIDSVYDSEDEVVASYDKVKHLPYLRACLDESLRIFPPTSHGLPRET
PPEGMEILGQWVPGKTSVSMSAYVAHRDETVFPEAYLYKPERWLGEEGKA
LQPYFVAFSAGARSCIGRNISYLEQTVILATLVRR
YEFALPSKDWELQREETMNLILGGMPVKVWRRQLDGDA
>CYP630B3P Aspergillus nidulans
AN2191.1 55% to 630B1pseudogene
MLEPILALLLVYSFYSYLVAPIITYIWDPKNLRRYPNFHPLPGISDIPFLLAAQKVF
RSRTLHALHQHHPIVCVGPNALSYGAPTAIKDIYGHGT
TCVKDRFYSEKSGSHAHLANVV
GKQDHARKRKVLASAYAIKNPEG*EYKLSGMTARLMRV
FEGKCTEPLPSSV*ATEERDLTIDFRSLTNHFT
VVAIANIGLTEDL
GFHEQGSDTNSLESMDGRVKDVSFKECREASGTVAYRLIWAYDWFPVLKR
LSKVLSPYYRKLGKLDADWNGIVYNRATRRLNV
GEKLDDFFTAMMEDKKGAAHNLETGEIVAEI
SIMMNAGSDTTAIALRNVLFLLLKNPRCMARLREEINVVLDEDELVAPYS
KVKHLPYLRACLDESLRMLPPVVFGLPRRTPPEGTTILGEHVA
GDTSVSMSAYVVHDESFFKDNSTYLPERWLGE
RSKSLQSYFIPFSARARGCI GRNISYL*QTVVLASL
VHRYDFALP
XXXXXXXXXXATNLSPGPMPLKFGRGFMHDE*
>CYP630B4 Nectria haematococca
e_gw1.1.300.1
Necha1/scaffold_1:1594762-1596339
84% to CYP630B1 no introns
This gene model seems correct
MYAEAVVIFTAASLITYFILYPVIEYLRDAKGLRRYPKFHPLAGISNLPFVREAARGFRSKTLYEMHKEH
PVIRTGPNSLSYGSVQAIKDIYGHGTKCLKGEFYETLAGSHFHLADVVDKADHARKRRALSAAYALKNLE
NWEFKVADKTERFIRAADAACTLPLKKGFVRPDPTDLTFDYRAFTNFFTLDAIADIGLSERLGFLDQGHD
LVKAERMDGTIHEVNYRECLHSTARAQSILAWTEGWYNFNVELSKWISVDFRKWWHLNEGWNDIVYHRAT
QRLERYKKGERLPDFFQALMDHSDANPPGLEWGEIVAEVSIMMNAGSDTTAIAMNNVMYWLLKNPSCMAK
LREEVDSVLEPDEIVAPYDKVKHLPYLRACLDESLRITPPTTFGLPRRTPPEGWNILGDFIPSDTTVSIS
AYVTHRDPSIFPEPESYVPERWLGEQGKDLQPYFIAFSAGARGCIGRNISYLEQTVLLASVVHR
YEWALPYPEWEPERREAMNLSPGPMPLKVWRRELEVEEKQG*
>CYP630B5 Nectria haematococca
e_gw1.52.31.1
Necha1/scaffold_52:135577-137148
65% to 630B1, no introns
This gene model seems correct
MYAYLLLAAVAVFFVFTFVLHPLYAYLSDPKHLRRYPNFHPLSGITNIPFMVEATRGFRSKALREQHKKR
PVIRIGPNSLSYGTGRAIKDIYGHGSGCIKGELYEVLAGTHFHITDVIDKYEHQRKRKAVSAAFALKNME
NWEYKVADKTERFIRACDKACTPPLKKEMTRPNPEDLTFDYRSYTNFFSIDAIADIALSEHLHLLDKGTD
IVQAERMDGSKFQVNFRDCLHGTARAQSIIVWASQWFKFNKWFTRLVSPEFRRLWKLNDGWEALVYNRAT
ERLKRYQNGEKLSDIFQAFMEDRDGNPRGLEWGEIVAEVSILMNAGSDTTGIAMCNVMYWLLKHPDCMTR
LREEVDAVLDADEVVAPYDKVKHLPYLRACLDETLRISPSTSFGLPRRTPAEGAYILGDFIPGDTTVAIS
AYVAHRDEEIFPDPDKFIPDRWLGEKGKDLQPFFIAFSAGARGCIGRNISYLEQTVLLASVVHR
YEFALPHPDWEQTWLEALNAMPGKMPLKVWRRDLSNREV*
>CYP630B6 Nectria haematococca
e_gw1.20.309.1
Necha1/scaffold_20:354486-356086
60% to 630B1 F. gram., 58% to e_gw1.52.31.1
This gene model seems correct
MYAVVVSVSFLSFLVYYFVLSPVWLYLRDPKGFRKYPAMNSLAGITDLGFMYEASKGFRTKRLTELHKKY
PVVRIGPNSLSFSGVQAIKASP (0)
EIYGHGTPCTKDHFYVVTGGSHTHLADVVNKADHARKRRVLSSAYAIK
NLEDWEYKVADKTERFIKACDAACTLPSKGSADPHPDELTFDYRKWTNFFTVEAIADIGLSEKLGFLDNG
SADCTAEKRDGTLYTANFVESLHNTAIAQSRLVWGYSWYKTNEYLARLLSKDFRRMLRLGDQFDDIVYHR
ATKRLARYRAGEKLDDFFQALMEDKNGRQNNQEWGEIVAEVSIMMNAGSDTTAIAMNNAMYHLLKHPDVL
KKLQEEVDSALDEEEEVAPFAKVKHLPYLRAVIDETLRITPSVTFNLPRRTPQGGCAIGDEFIPGETSVS
ISAWTAHRDEEVFPEPEEFRPERWLGEGAQELQRGFIAFSTGARGCIGRNISYLEQTVLLASVVHRYGMA
LPSKDWTPELDEGTNLLTKEMPVKVWRRRV*
>CYP630B7 Nectria haematococca
fgenesh1_pg.scaffold_50000029
Necha1/scaffold_50:99287-100920
58% to 630B1, 60% to e_gw1.1.300.1
This gene model seems correct
MSVSVASLGTTPYAAALGVVAVIYFLIYPFVLYLRDSK (1)
GLRRFPNMSTFSGMSNLPFMILAHGGARSSAM
AKMHKTEPILRTGPNTLSFGSVKAIKGIYGHGTPCIKDESYVLTAGTHFHLADVIDKPDHARKRKVLSSA
YALKNLEEWEYKVADKVQRMMNHFEKCCTAPLSKGVKYPNPEDVNVDFRAWSNFFSLDAIADIGLSEKLG
LLDRGHDRVEAQEKNGTIFEANLRECLYPTARKQSLLLWSYDNYKLLDKISNIIPYYRRMSESSRGWDAI
VLRRANLRLQRYNAGEKLDDFFQALMEDKSGNPHNLEWGEVVAEINIMMNAGSVTTAIALANVLYQLLLN
PDKMETLRNEIDSVLEPDEMVAPYDKVKHLPYLRACLDESLRLWPPTPQSLARKTPPEGTTIMGQYIPGN
TTVGISALVAHRDETAYPEAEKYLPERFLGEKGKELQSSFITFSAGARGCIGRNISYLEQAVCLASIVHR
YDFALPAGFELKREETMNHILGEMPVKVWRRDLGEEE*
>CYP630B8P pseudogene Nectria haematococca
fgenesh1_pg.scaffold_30000003
Necha1/scaffold_30:23907-24329
55% to fgenesh1_pg.scaffold_50000029 mid to
heme, 52% to 630B1
add
cyan region (seq missing after GLNVI)
RLERNRRMEKLDDTFQALTRHQTGTPHNLEWGQVVVEVNIMTNAGSVATAVALTNVFYRVIRTP
RARALLRKEPDAALEPDKVIALDDKAKHPPYLRACLHECPRLFPPTTHGLPRKTSPDGLNVI
LGKKSKELQPWFITFSTGSRACIGRNISYPEQTVLIA
>CYP630B9 Aspergillus fumigatus
GenEMBL
XP_755127.1 EAL93089
join(AAHF01000001.1:159023..159128,
AAHF01000001.1:159173..160644)
61% to
CYP630B1 FG
MWSLFTIAPYACILGLLLFVYFIAYPFVEYIRDPKGLRRYPNFHPFSGMSAIPFMVLASRGFRSMELLNL
HRKHPVLRTGPNTLSYGDVRAIKDIYGHNTKCIKDPSYIVTAGTHYHLADVVDKPDHARKRKVLSSAYAL
KNLETWEYKVSDKLERLIAHFDRVCTKPPSAAVAEGKAAPDPADLTVDFRAWTNFFTLDAIADIGLSEKL
GFLDSGSDVCTAERKDGTTYEVHLREALYPTARKQSLILWNYEWYPVLNKLVNIIPFFRRMQRSSDNWEN
IVWRRASQRLRRYEAGEKLDDFFQALMEDKNGHPNNLEWGEIVAEVNIMMNAGSVTTAIAIANVMYQLLK
NPRCLAKLREEVDAVLDEEDIIAPYDKVKHLPYLRACLDESLRIFPPTSHGLPRQTPPEGMEILGQWVPG
NTSVSISALVAHRDESVFPQADQYIPERWLGEEGKALQPYFVAFSAGARSCIGRNISYLEQTKAIATLVH
RYEFALPHPGWELKRLETMNLILGDMPVKVWRRQT
>CYP630B9 Neosartorya fischeri
97% to CYP630B9 Aspergillus fumigatus = ortholog
NFIA_083610
MWSLFTIAPYACILGLLLFVYFIAYPFAEYIRDPKGLRRYPNFHPFSGMSAIPFMVLASRGFRSMELMKLHRKHPVLRTG
PNSLSYGDVRAIKDIYGHNTKCIKDPSYIVTAGTHYHLADVVDKPDHARKRKVLSSAYALKNLETWEYKVSDKLERLIAH
FDRVCTKPPSPAVAEGKAAPDPADLTVDFRAWTNYFTLDAIADIGLSEKLGFLDSGSDVCTAERKDGTTYEVHLREALYP
TARKQSLILWNYEWYPVLNKLVNIIPFFGRMQRSSDNWDNIVWRRASQRLRRYEAGEKLDDFFQALMEDKNGHPNNLEWG
EIVAEVNIMMNAGSVTTAIAIANVMYQLLKNPCCLVKLREEVDAVLDDDEIIAPYDKVKHLPYLRACLDESLRIFPPTSH
GLPRQTPPEGMEILGQWVPGNTSVSISALVAHRDESVFPQADRYIPERWLGEEGKALQPYFVAFSAGARSCIGRNISYLE
QTKAIASLVHRYEFALPHPGWELKRLETMNLILGDMPVKVWRRQRDMI*
>CYP630B10 Aspergillus fumigatus Af293
GenEMBL XP_748668.1 also EAL86630.1
46% to
630B2 with errors
closer
to 54% if gaps removed, needs revision
some parts of the middle of this sequence may
be out of order
MLGMMLLLGLLARLFFRFVIWAIFVYLRDPKGLRKYPLMHPLSGISDIPFMLESMRGFRSATLLQLHYGQ
GHPVIRLGPNALSFAGGQAIPAIYGHNTPATKDRQYLNAAGSHFHLADVVDKKEHARKRKVLASAFAAKH
LEDWEYKVADKVQRLMQRFDQHLAQMPDDPLDYRSWTNLFTIDSLCDTLIVAPTVSFRDCLYATFHIVGD
LVWSYEWYHVVSWLLQRVSAHDIFAALMEDPAGNPQDLEWGEVLAEISLAISGSSSTSNSIASTMQLLIE
HPEKMRKLQEEVDSVMATQLEDSPDGDTPTVASYDQIKSLPYLRAVIDESLRLYPPISHGLPRETPKEGM
MIMDQWVPGNTTVSVSAYVAHRDPAVFDQPESFVPERWLGEQGRALQTRFIAFSAGARGCIGRPISYLQA
SILLANLVHQYDFEMWDPKWKPSRRETMNLIMGPMPPGGFSGEGG
>CYP630B11 Aspergillus oryzae
GenEMBL BAE66547.1
59% to
630B2
MYSLLLIVTLHFLLIYYIIIPIINYFRDPKGLRKYPNLTFVSGISDLPLIYYSHKGIRSRVLFEAHKKHP
VLRIGPNKLSYADPVAIKDIYGHGTKCTKDVFYSALSGSHYHLADVVDKEDHARKRKVLSNAYAIKNLEG
WEYKVADMTQRIIKAFDERCTSPLPKGRNPDPQDLTIDYRMWTNLYTIAAIANIGLSEDIRFLDQGNDII
SSEAKDGTVKKVHFRDCLYANASATSTLVWAYDWYEALVRVSKLVSSTYRQKWKLAEDWDGIVNNRATTR
WKRYEKGEKLDDFFSALMEDKAGAPNNLEWGEIVAEVSIMMNAGSDTTGISLNNVMLLLLKNPHCLEKLR
EEIDGVLEDDEVIAPYDKVKHLPYLRACLDENMRMYPPVSFHVPRRTPQEGTMIRGEFVAGNTSVGISAY
VVHRNEDIFPDPDTYKPERWLGDKGRDLQPYFVAFSAGARGCIGRNISYLEQTVLLASLVHRFEFALPSP
SWEPVRHETTNFNSGPMPLKVWRRASRVYEDN
>CYP630B11 Aspergillus flavus
100% to CYP630B11 Aspergillus oryzae
AFL2G_11866
MYSLLLIVTLHFLLIYYIIIPIINYFRDPKGLRKYPNLTFVSGISDLPLIYYSHKGIRSRVLFEAHKKHP
VLRIGPNKLSYADPVAIKDIYGHGTKCTKDVFYSALSGSHYHLADVVDKEDHARKRKVLSNAYAIKNLEG
WEYKVADMTQRIIKAFDERCTSPLPKGRNPDPQDLTIDYRMWTNLYTIAAIANIGLSEDIRFLDQGNDII
SSEAKDGTVKKVHFRDCLYANASATSTLVWAYDWYEALVRVSKLVSSTYRQKWKLAEDWDGIVNNRATTR
WKRYEKGEKLDDFFSALMEDKAGAPNNLEWGEIVAEVSIMMNAGSDTTGISLNNVMLLLLKNPHCLEKLR
EEIDGVLEDDEVIAPYDKVKHLPYLRACLDENMRMYPPVSFHVPRRTPQEGTMIRGEFVAGNTSVGISAY
VVHRNEDIFPDPDTYKPERWLGDKGRDLQPYFVAFSAGARGCIGRNISYLEQTVLLASLVHRFEFALPSP
SWEPVRHETTNFNSGPMPLKVWRRASRVYEDN
>CYP630B12 Aspergillus oryzae
GenEMBL BAE65338.1, AP007171.1
57% to
630B11, 75% TO 630B13, 77% to 630B2
14 P450
genes and 2 pseudogenes on this contig
MWSALSIAPYALVLGLFSLLYFVVFPWVEYIRDPKGLRKYPNMNPFSGMSAVPFMLLASRGFRSKELQEL
HRTKPVIRTGPNMLSYGDVRAIKDIYGHNTKCIKDPSYIVTAGTHYHLADVVDKPDHARKRKVLSSAYAL
KNLETWEHKVSDKVEKVVAHFDKVCTAPPSAAVAAGKMAPDPKDLTVDFRAWTNFFTLDAIADIGLSEKL
GFLDSGSDVCIAERKDGSTYEVNLREALYPTARKQSLILWNYEWYPVLNKMVNIIPFFNRMQNSSDNWDN
IVWRRSMNRLRRYEAGEKLEDFFQAMMEDKNGRANNLEWGEIVAEMNIMMNAGSVTTAIAIANVMYQLLR
NPQSLKKLQEEIDAVLDADEIVAPYDKVKHLPYLRACLDESLRIFPPTSHGLPRETPPEGMEILGEWVPG
NTSVSMSAYVAHRDESVFPKADQYIPERWLGEEGKALQPYLIAFSAGARSCIGRNISYLEQTKILATLVH
RYDFALPYPGWELKRLETMNLILGDMPVKVWRRNVQEA
>CYP630B12 Aspergillus flavus
100% to CYP630B12 Aspergillus oryzae
AFL2G_05615
MWSALSIAPYALVLGLFSLLYFVVFPWVEYIRDPKGLRKYPNMNPFSGMSAVPFMLLASRGFRSKELQELHRTKPVIRTG
PNMLSYGDVRAIKDIYGHNTKCIKDPSYIVTAGTHYHLADVVDKPDHARKRKVLSSAYALKNLETWEHKVSDKVEKVVAH
FDKVCTAPPSAAVAAGKMAPDPKDLTVDFRAWTNFFTLDAIADIGLSEKLGFLDSGSDVCIAERKDGSTYEVNLREALYP
TARKQSLILWNYEWYPVLNKMVNIIPFFNRMQNSSDNWDNIVWRRSMNRLRRYEAGEKLEDFFQAMMEDKNGRANNLEWG
EIVAEMNIMMNAGSVTTAIAIANVMYQLLRNPQSLKKLQEEIDAVLDADEIVAPYDKVKHLPYLRACLDESLRIFPPTSH
GLPRETPPEGMEILGEWVPGNTSVSMSAYVAHRDESVFPKADQYIPERWLGEEGKALQPYLIAFSAGARSCIGRNISYLE
QTKILATLVHRYDFALPYPGWELKRLETMNLILGDMPVKVWRRNVQEA
>CYP630B13 Aspergillus oryzae
BAE63103.1
75% TO
630B12, 62% to 630B7
MLSLVLVAPYAAVGGLCTLLYFFVFPFIEYIRDPKGLRKYPNLHPISGMSVLPFMFMASRGARSQELSEL
HKKSPVIRTGPNTLSYGDVRAIKDIYGHNTKASKDPSYIVSAGTHYHLADVVDRADHARKRKVLSSAYAL
KNLETWEYKVSDKIERLVKHLDKCCTAAPVSGGRAFVPSSEDLTVDIRAWINFFTLDAMADIGLSEKLGF
LDKGNDICVAERKDGSTFECGLRDALYPLAIKQCMVLWNYEWFPIINKLVDVFPYFRNLQKKGDAWEHII
WRRSSERLRRYEAGEKLNDFFQALMEDKNGRPNNLEFGEIAAEVNIMMNAGTVTTAIAITNVLYQLIRHP
EAMAKLREEIDGVLGPDEIVASYDTVKHLPYLRACLDESLRILPPTPHGLPRQTPPEGMEILGEWVPGNT
LVSISAYVAHHDESVFPQPHKFIPERFLGEAGKELGPYFITFSAGARSCIGRNISYLEQTKALATLVHRY
DFALPYPDWEPKRFESMNHILGEMPIKIWRRSFDG
>CYP630B13 Aspergillus flavus
99% to CYP630B13 Aspergillus oryzae
AFL2G_08530
MLSLVLAAPYAAVGGLCTLLYFFVFPFIEYIRDPKGLRKYPNLHPISGMSVLPFMFMASRGARSQELSELHKKSPVIRTG
PNTLSYGDVRAIKDIYGHNTKASKDPSYIVSAGTHYHLADVVDRADHARKRKVLSSAYALKNLETWEYKVSDKIERLVKH
LDKCCTAAPVSGGRAFVPSAEDLTVDIRAWINFFTLDAMADIGLSEKLGFLDKGNDICVAERKDGSTFECGLRDALYPLA
IKQCMVLWNYEWFPIINKLVDVFPYFRNLQKKGDAWEHIIWRRSSERLRRYEAGEKLNDFFQALMEDKNGRPNNLEFGEI
AAEVNIMMNAGTVTTAIAITNVLYQLIRHPEAMAKLREEIDGVLGPDEIVASYDTVKHLPYLRACLDESLRILPPTPHGL
PRQTPPEGMEILGEWVPGNTSVSISAYVAHHDESVFPQPHKFIPERFLGEAGKELGPYFITFSAGARSCIGRNISYLEQT
KALATLVHRYDFALPYPDWEPKRFESMNHILGEMPIKIWRRSFDG*
>CYP630B14 Aspergillus niger
fgenesh1_pm.C_scaffold_20000049|Aspni1
77% to CYP630B11
MYIPIVILLLSLLTIYYFIIPIINYFRDPKGFQKYPNLTFWSGISDLPLVYFSHKGIRYKRLLEAHKTHPVVRIGPNYLS
YADPDAIKDIYGHGTTCTKDLFYSTLGGSHFHLADVVDKEEHARKRKVLSSAYALKNLETWEYKVADMTNRLIKAFDARC
TDPLPKGHRPLEKDLTIDYRMWTNLFTIAAIANIGLSEDIKFLDQGNDLITSESMDGMTKKVHFRDCLFATGSATATLVW
SYDWYKTLARASKILSPTYHRKWKLNKDWDGIVYNRATTRWKRYQNGEQLDDFFSALMADKSDVPHNLEWGEIVAEISIM
MNAGSDTTGISLSNVMLLLLNNPACLEKLQEEVDGVLDDDEIVAPYDKVKHLPYLRACLDESLRLYPPVSFALPRRTPPE
GTMILSDHIAGNTSVGMSAYVVHRNESIFPDPEAFRPERWLGEKGKELQPYFIPFSTGARGCIGRNISYLEQTILVASLV
HRFDFALPYPGWEPERHETTNLGSGPMPMKVWRREVAA*
>CYP630B15 Aspergillus niger
fgenesh1_pm.C_scaffold_9000258|Aspni1
88% to CYP630B12
MWSLFTIAPYAFFIGIVGISYFLVWPFVQYIRDPKGLRKYPNLTPISGMSAIPFMLMASRGFRSRELQELHQEKPVIRTG
PNTLSYGDVRAIKDIYGHNTKCIKDPSYVVTAGTHYHLADVVDKGDHARKRKVLSSAYALKNLETWEHKVSDKVEKVVAH
FDKVCTAAPSAAVASGKVAPDPKDLTVDFRAWTNYFTLDAIADIGLSEKLGFLDQGSDVCIAERKDGSTYTVHLREALYP
TARKQSLILWNYEWYPVLNKLVNVIPFFGRMQKSSDNWDNIVWRRSIERLRRYEAGEKLDDFFQALMEDKNGRANNLEWG
DVVSEVNIMMNAGSVTTAIAIANVMYQLLRNPECLAKLREEIDAVLDADEVVAPYDKVKHLPYLRACLDESLRIFPPTSH
GLPRETPEEGMEILGQWVPGKTTVSMSAYVAHRDERAFPKADQYIPERWLGEEGKALQPYFVAFSAGARSCIGRNISYLE
QTKILATLVHRYEFALPYPGWELKRLETMNLILGDMPVKVWRRQVPATD*
>CYP630B16 Fusarium oxysporum
90% to CYP630B4 Nectria haematococca
FOXG_03207
MYAQVVSVFTAVCLLTYFALYPIYTYLRDAKGLRRYPNFHPLAGITNIPFVREAAKGFRSRTLYEMHKTHPVIRTGPNSL
SYGSIQAIKDIYGHGTKCTKGEFYETLAGSHYHLADVIDKADHARKRRALSAAYALKNLENWEFKVADKAERFIRAADAA
CTLPLKEGFTRPDPRDLNFDYRAFTNFFTLDAIADIGLSERLGFLDQGHDRVKAERMDGTIHEVNFRECLHSTARAQSIL
AWTEKWYNFNVEVSKWFSKDFRQWWHLNEGWNDIVYHRATQRLERYKNGERLPDFFQALMDHSEANPPGLEWGEIVAEVS
IMMNAGSDTTAIAMNNVMYWLLKNPSCMAKLREEVDSVLDPEEIVAPYDKVKHLPYLRACLDESLRITPPTTFGLPRRTP
PEGWNILGDYIPGDTTVSISAYVTHRDPQVFPDPESYAPERWLGEKGKDLQPYFIAFSAGARGCIGRNISYLEQTVLLAS
VVHRYEWALPYPEWEPERREAMNLAPGPMPLKVWRRDLGVEEVDEKGN*
>CYP630B17 Fusarium oxysporum
81% to CYP630B7 Nectria haematococca
FOXG_02681
MSASVASLGSAPYAAAVGFAVVFYFIIYPFILYLKDPKGLRRFPNMSPFSGMSNLPFMILAHGGARSTHLAKLHKTKPII
RTGPNSLSFAGGQAIKDIYGHGTPCTKDKSYIVGAGTHFNLADVVDKHDHARKRKVLSSAYALKNLEGWEYKVADKVQRM
MDHFDKVCTAPLQKGARFPDPQDVNVDFRAWSNFFSLDAIADIGLSEKLGLLDQGHDRVEAQQTCGTVYETNLRECLYPT
ARKQSYLLWTYDYYKLLNKISNVIPFYRKMSESAKGWDDIVLRRAQIRLDRYQKGEKLDDFFQALMEDKNGNSHELEWGE
IVAEINIMMNAGSVTTAIALANILYQLILNPRVMELLRHELDSVLEPDEVVAPYEKVKHLPYLRACLDESLRLWPPTPQN
LGRQTPPEGLTIMGQYIPGNTSVGVSALVAHRDECIYPESEKFIPERFLGEKGKELQSHFITFSAGARGCIGRNISYLEQ
TVCLASIVHRYEFALPAGFELKREETMNHILGPMPVKVWKRNLEE*
>CYP630B17 Fusarium verticillioides
95% to CYP630B17 Fusarium oxysporum
FVEG_01518
MSASIASLGSAPYAAAVGVAVIIYFIVYPFIAYLKDPKGLRRFPNMSTFSGMSN
LPFMILAHGGARSTHLAKLHKTKPIIRTGPNSLSFAGGQAIKDIYG
HGTPCIKDESYIVGAGTHFHLADVVDKHEHARKRKVLSSAYALKNLEGWEY
KVADKVQRMMNHFDKVCTAPLPKGAKFPDPQDVNLDFRAWSNFFSLDAI
ADIGLSEKLGLLDQGHDRVEAQQTCGTVYKANLRECLYPTARKQSYLLWTYDH
YKLLNKISNIIPFYRKMSNSAKGWDDIVLRRAQIRLDRYQRGEKLDD
FFQALMEDKNGNSHELEWGEIVAEINIMMNAGSVTTAIALANILYQLILNP
RVMELLRQELDSVLEPDEAVAPYEKVKHLPYLRACLDESLRLWPPTPQN
LGRQTPPEGLTIMGQYVPGNTSVGVSALVAHRDESIYPESEKFIPERFLGE
KGKELQSHFITFSAGARGCIGRNISYLEQAVCLASIVHRYEFALPAGFE
LKREETMNHILGPMPVKVWKRNLEE*
>CYP630C1 Nectria haematococca
e_gw1.19.274.1
Necha1/scaffold_19:134969-136557
46% to 630B1, 630B1 has a deletion near heme
signature
same gene as fgenesh1_pg.scaffold_19000054
This gene model seems correct
MESFIVFTTALFLLFIIEPFARYLWDPQNLRRFPSHNPLSSITNLGYIIERCRGFRSRNLHEAHKKHSVV
RIGPNSLSFSSPKAIRSIYGHSTNCIKGDMYAASAGPHDSLLDVIDKEAHARKRRYMSHALATRNLETWE
HKVADKVRTLVRQFDRICDGAASATNTKTGTLDFRKWTNLFTIEAIADIALSHKLGCLDRGDDQVTVTTA
DGNEKRVHYIKCLHAGKRATSTLVWANSWFRFLRTVLTLLPGWFRSQWLKGAQFDDMVHHLTRVRVERHQ
TGETLDDIVHCLIEDKNGELRGLDIGEIEAEVGVL (1)
LDAGSDTTAIALTHVMHSLLRHPNALQRLRDELKE
TLDVDNPVASYDQVKNLPYLRACLDESLRLLPPVSFGLNRKTGPGGLTIDGQWIDEGITVGVPAYTAHRN
PQLFPDPERYHPERWLEEMHKDAKASFIPFSAGARGCIGRNITYMEQMILIASLVQRYDFALPDDGWELD
HEEAFNLWPGPMPLSISKR*
>CYP630D1 Aspergillus oryzae
GenEMBL BAE60571.1
43% to
630B2, 48% to 630C1, 44% to 630B5, 43% to 630A3
MALEKLFIVVFLCFALRPLLLYFYDSKKLRKYPNQNFLSGVTNLASIRERQRKFRTRELYLQHQKHPIIR
VAPNMLSFRDVKAIKDIYGFGSPCQKHEIYKLQNSEGHMNILNVIDREDHNRKRRMLSHAFSTKNLESWE
FKITDKVEKLVAQFDRRAHPPAWKNEPSQQNNTTVDVRYWLNLFTVDAIADIALSERLGMLESGSDVVKV
GGPGEEDSAHRFIEDMHEAARVKSKIIGTLDWYYVLKQVSSFLSSRCRSQWDCGGNVGQIVEHLAGKRLR
RHEDGENIDDFLSCLINDKAGKSRNLDIGELKAETSILLDAGSETTAIALTHLLYYLIKNPDCFVKLRKE
VSGAIAGDKVAPYAKVKSLPYLKACIEESLRLSPPLPRGLERVTPAAGAYIMGEFIPGNVGVSVPAYVAH
RDPDLFPEPEAFLPERWFNNENIGKMRDAFIPFSAGGRACIGRNITMIEQQILIATLVHRYDFSLASPDW
TLQNEEAFNLWPVELPVKIWERDLEA
>CYP630D1 Aspergillus flavus
98% to CYP630D1 Aspergillus oryzae
AFL2G_03294
MALEKLFIVVFLCFALRPLLLYFYDSKKLRKYPNQNFLSGVTNLASIRERQRKFRTRELYLQHQKHPIIRVAPNMLSFRD
VKAIKDIYGFGSPCQKHEMYKLQNGEGHMNILNVIDREDHNRKRRMLSHAFSTKNLESWEFKITDKVEKLVAQFDRRAHP
PAWKNEPSQPNNITVDVRYWFNLFTVDAIADIALSERLGMLESGSDVVKVGGPGEEDSAHRFIEDVHEAARVKSKIIGTL
DWYYVLKQVSSFLSSRCRSQWDCGGNVGQIVEHLAGKRLRRHEDGENIDDFLSCLINDKAGKPRNLAIGELKAETSILLD
AGSETTAIALTHLLYYLIKNPDCFVKLRKEVSGAIAGDKVARYAKVKSLPYLKACIEESLRLSPPLPRGLERVTPAAGAY
IMGEFIPGNVGVSVPAYVAHRDPDLFPEPEAFLPERWFNNENIGKMRDAFIPFSAGGRACIGRNITMIEQQILVATLVHR
YDFSLASPDWTLQNEEAFNLWPVELPVKIWERDLEA*
>CYP630D2P Aspergillus oryzae
GenEMBL BAE62696.1, AP007166.1
Downstream from CYP551A2 (BAE62699.1) (145541-147583)
note:
two other genes between these
This
gene is a pseudogene missing the top half
39% TO
630D1, 37% to 630B1
136724
VQTTEYYRSLQEHGKDGCFDNTIFDSVLRSFAEIQEGSNLTKVQTEKLVDEAFAI
MFAGSDTTAFSLTITLVYLCKYPEKIVKLRREVQCLRDFKVQDIQLATISQMPYLDAVIREANRLSSPLS
TVLPREVPSTGCVISGHFLPKGTVVGFHLDDINRNPKFFPEPNDFIPERWSGEEGKKLQRWFVPFSKGSR
RCIGMDFAFVEMKLAVAAIISRFEIWLDNPNVTLNSREMFVKIPEDDLRIRLRAITV
135844
>CYP630D2P Aspergillus flavus NRRL3357
GenEMBL AAIH01000541.1 pseudogene
same
gene as Aspergillus oryzae BAE62696.1,
97%
identical
runs
off the end
AFL2G_08101
418
VQTTEYSRSLQEHGKDGCFDSTIFDSVLRSFAEIQEGSNLKVQTENLVDEAFAI
MFAGSDTTALSLTITLVYLCKYPEKMVKLRREVQCLRDFKVQDIQLATISQMPYL
(0)
DAVIREANRLSSPLSTVLPREVPSTGCVISGHFLPKG (0)
TVVGFHLDDINRNPKFFPEPNDFIPERWSGEEGKKLQRWFVPFSKGSRRCIGMDFAF
VEMKLAVAAIISRFEIWLDNPNVTLNSREMFVKIPEDDLRIRLRAITV*
1301
>CYP630D3 Aspergillus niger
fgenesh1_pg.C_scaffold_2000776|Aspni1
54% to CYP630D1
MALLLTLTLIILALLIKALLTYLLNTKTITLTKYPPLNPLSNLTTLSYTYEHRHPFRTQRLYNLHRQHNHPIIRLSPTAL
SIADPKAIPAIYGHGTPCLKDDVYALTKGTHTHSNMLNTISRDDHSRKRRMLANAFSTKNLENWEFKIVDKVERLLRQLD
GRCSSSSNGEMDGNEVDLRFWLNLFTIDAIADIGLSVQLGLLDRGSEEVDVDGEVVRYIECLHRGNRVSSWVIGASGWVG
FLRGVSRVVSPYLREQWECGRRFGRVVRSLVEQRVSVQEGRETLSDFLGCLNEDKRGVGRELEKGEIEAEAGLLLDAGSD
TTAIALTNVMYYLIKNPQSLIKLREEVSGAILENGVAPYVKVRNLPYLKACLEESLRLSPPVPRGLERKTPPEGMYILGE
RIPGNFTVSVPTYAVHRDPEIFPDPEAFRPERWLEDDEKIKQMRAVFIPFSSGARACIGRNITFMEQQILVATLVHHYEF
ALPSKDWMLEWEEAFNLWPGRMPVRIWRRDE*
>CYP630D4 Neosartorya fischeri
57% to CYP630D1
NFIA_005950
Note: this seq does not have an ortholog in A.
fumigatus
MAFTLILMVALAYLCARPFIVYFYDAKGLRKYPNLNPLSGITSLAYVWEHSNNFRTRRLYLKHRKHPVIRVGPNVLSFAD
VRAIKDIYGHGTPCRKDDVYSLTVGSHAHILNTVDREDHNRKRRMLSHAFATRNLERWEFKIVDKIGKLITQLDRRCTAP
LSDRHHVNSEDLTLDFTLWSNLFTIDAIADLALSEQLNLLDSGTDVVKVDNIPSLKFIDSLHGGNYITSLFVGAANWFAV
LKALSRIVSPLFRAQWDHGRNYGRIVSALTGKRLEKHQRGGQLGDLFACLMEDNKGNARGLERGELEAEVNVLLDAGSDT
TAIALTHALYYLIKTPHALATLRKEVAGAFSEEPIARYASVKNLPYLKACLEESLRLSPPVSRGLERRTPPEGMRIMGEE
IPGDVGVSVPVYVAHRDPAIFPEPALYRPERWLESEENVKQMREAFVPFSTGARGCIGRNITMIEQQLVIATLVHRYDFA
LPSDHWSLQHNEAFLLWPGPMPLKIWRRDLGSATSMRNDL*
>CYP630E1 Uncinocarpus reesii
51% to CYP630B14 A. niger, added back part of
heme region
UREG_00268.1
MIGTLIAPICFAALAIIIFKPVALYFLDRKNLRKFPTLHPLSGLSDIPFMVESMKGFRSARLAELHHGKGWPVIRIGPNS
LSFGTVDSIKAIYGHNSPTTKDKQYVNASGTHFHLADVVDKKEHARKRKVLASAFAAKNLEDWEYKVGEKVSRLIDQFDK
YVEESAEGPLNYRSWTNLYTIDCL
VDICLSTQLHCIERGEDTVTAEDLAGITE
DVSFRDCLYATFHLVGDLVWSYDWFST
IITVANTISPVYSRLIKLGTGWRNLVHHLTNKRWSRYAAGERINDIFSSLMDDTAGNAHNLEWGEVVAEISLAVSGSSST
SNTIASTMQLLIENPQKLEKLQEELDSVMEPEEIIASYDKVKYLPYLRAVIDETLRLYPPISHGLPRETPKNGLQILDNW
IAGNTTVSVSAYVAHRDPNAFPEPEKFMPERWLGDEGKQLQPNFIAFSAGARGCI
GRPISYLLAT
VLLASLAHRYDFFKFSSDWKPRRRE
TMNLILGSLPIRIQKRSL
>CYP631A1 Fusarium graminearum FG10329.1
AACM01000425 FGcontig1.425_scaffold7
YVSSDFALAFLAIGFSSVLIYQLAHNYRRLQHIPGPLVAKLTDIHRFMLV
RSGFIHLYQASAHERYGSVVRFGPNLVSICDPEAIQEVFNMRNGFNKSNM
YRAFRPWTPAGLLVSVFTAKDDIVNRQMKQHIAVYFSLSYTAASFEERVD
NAIRIFFKQLDSQFVTTGAKIDLTRWFKFFSYDAMGLMTFSRPYGCLENS
SDAAGIISDVKNSMLAIGPMTQMPWLDWLLHKNGLINMIKPEPVSALLKY
VLARISERRNSPKAMHSTVTDGPDANGDFLGYFLQAQEKKSNKVPPQFLS
TWTLANILGGSDSTASMLRSVVCFLVENPDALETMRAELRDKKQHAEGSS
APIPKWTKIQDLPFLNACVIESLRLDPPFATTLERVVPPEGVTICGAFYP
GGTVVGMNPYITNRHRPTWGEDADQWRPSRWLEGDPAHIRKLQASLLSFG
AGTRGCLGQHVAVFEIKKLVVALFMNYNLNLVRLLSQFSKGLS*
>CYP631B1 Aspergillus nidulans AN3225.1 38%
to 631A1 53 clan
revised 7/19/07
MDHPHPSTFSL
GLSQILVCLALLYAAIHILSV
YRRLCHISGPFWARIS
NLPRVWWVNTSRAHEIHQQLHEKYGDVVRFGPNMVSLRNPTWIPTVYPTR
MGVKKSDFYRTLAPYTPSGALPAVFSSRDEEVHRGLRGPIASLYSMSKVL
PLEVFVDRTIDVLVRQLDGRFAGAGETFDLASWLQFFAFDVMGTLTFSKR
YGFLEKGMDVHGMLDTIWRFLKGAAPFTQIPWVDEIWNKNVLATKLKGAT
GVSILGIVGKFVSQRQEESKAGKIDGTADRDMLSLFMEIQKNNQLPPWYV
TAWTFSNITAGSDSAAVVMRTVFYNLLSHPSTLQKLRSELLSAGPLTQPY
PSWKDVCNLPYLDACILEALRLHPPFCLPFERIVPQGGMVLGDTYFPEGT
VVGMSPWVVNRHKPTFGEDSDVWNPERWMVSKELKSKREAAVLTFGAGRR
VCLGRHIAILELKKIVPALVLRYDFELIDPERFTTENFWFFRQRGMDVRV
KKRMQAEAGI*
>CYP631B2 Aspergillus oryzae
GenEMBL
BAE65443.1
52% to
631B1, 43% to 631A1
revised
3/19/2009
MLILLGLLCLYTGLYVARTYWRLRHFPGPL
VARFTDLGRLWWVKTSRSHHHHMGLHSRYGQYVRLGPNMISISDPDAIPLVYPIRPGVPK
()
SDFYRSM MPYTRKGRSLPLVFNTRDEDLHKRLKTPIAHLYSLSNILTFEAFVDQVLEILFRQFEERFVPDQAPFNLGNWL
QYFAFDVMGTMSFSRRYGFLEKGRDDTGLLSAIWAFMKAAAPVTQMPWVDLVWNKNPFIALFRATPAQPI
LNVVLSRINDRRNELYSTTSTPEKVNERDFLSRFMHIQSNSDTIPPWAVTAWSFSNVIAGSDTTAVAMKT
LWYNLLLHPATMHRLRKELVQAQQQSKLSHPFPAWNEISGLPYLNACVNEALRIHPPFCLPFERIVPAEGMTIGD
HFFPGGTVIGMNPWVINRHRPTFGEDADAWRPERWLEDPARTRQMEN
TLLSFGAGRRVCLGKNIALLELKKLTSALVLHYE
LEIVNPEKFQSQNFFFFKQEGLYAAVKRRSAGSPELYPDDAVPH
>CYP631B2 Aspergillus flavus
100% to CYP631B2 Aspergillus oryzae
AFL2G_12402
MLILLGLLCLYTGLYVARTYWRLRHFPGPL
VARFTDLGRLWWVKTSRSHHHHMGLHSRYGQYVRLGPNMISISDPDAIPLVYPIRPGVPK
()
SDFYRSMMPYTRKGRSLPLVFNTRDEDLHKRLKTPIAHLYSLSNILTFEAFVDQVLEILFRQFEERFVPDQAPFNLGNWLQYFAFDV
MGTMSFSRRYGFLEKGRDDTGLLSAIWAFMKAAAPVTQMPWVDLVWNKNPFIALFRATPAQPILNVVLSRINDRRNELYS
TTSTPEKVNERDFLSRFMHIQSNSDTIPPWAVTAWSFSNVIAGSDTTAVAMKTLWYNLLLHPATMHRLRKELVQAQQQSK
LSHPFPAWNEISGLPYLNACVNEALRIHPPFCLPFERIVPAEGMTIGDHFFPGGTVIGMNPWVINRHRPTFGEDADAWRP
ERWLEDPARTRQMENTLLSFGAGRRVCLGKNIALLELKKLTSALVLHYELEIVNPEKFQSQNFFFFKQEGLYAAVKRRSA
GSPELYPDDAVPH
>CYP631B3P Aspergillus oryzae
GenEMBL BAE56559.1, AP007152.1
52% TO
631B2, 56% to 631B1
pseudogene
24632
NLLTHPATLQALSSELITANLTLPYPKWNEVCDLPYLDACIQEAVRLHPPF
ALVLGRVVPAGGVTVLN
HYLPEGTLVGGNPYVVNRHAETFGPDVEEWRPERWLEGEGRKRLEQSVPT
(0) 24276
FDAGRRVCLGKYIGILELKRLVPFLVLKYD (0)
MKIIDPERFSVENGFFFKQRGFYCNITRRKEGSDRDKADPK*
>CYP631B3P Aspergillus flavus
100% to CYP631B3P Aspergillus oryzae
LFYNLLTHPATLQ
ALSSELITANLTLPYPKWNEVCDLPYLDACIQEAVRLHPPFALVLGRVVPAGGVTVLNHYLPEGTLVGGNPYVVNRHAET
FGPDVEEWRPERWLEGEGRKRLEQSVPTFDAGRRVCLGKYIGILELKRLVPFLVLKYDMKIIDPERFSVENGFFFKQRGF
YCNITRRKEGSDRDKADPK
>CYP631B4 Talaromyces stipitatus
ABAS01000029.1 61% to 631B1, 44% to CYP5077A1
note this might be misnamed
MDSMNIFPGYRQADSIVFIAVGSILGLSL
285172
LHLLRTYWRLRYIPGPFLARFTNLQRVYWVKTTRAHEIHQQMHEKYGNVVRFGPNMVSLG 284993
284992
DPALIPSLYPIRPGFPK (0)
SDFYRSLMPYTRKGGSLPAV 284813
284812
FNTRDENLHKVIKTPIAPLFSLSNILPLEVFVNRVLEVLFQQLDTRFVSSGDTFDLADWL 284633
284632
QYFAFDVMGTLTFSKR 284585
YGFLEHGRDVNNMLLTIWTYMSNCAP (0)
MTQIPWFDVVWNKNAFITLFRRASGLSILGHVGELIA
DRRQRRNTPSAVSDEKASDRDMLSRFFELQEKDSKIPRW
(2)
AVTAWAFSNVIAGSDSTAVTMRTTWFGLLSHPETLKTL
RKELLDQDSKLEGGITRPFPAWKDICNLAYLDACVNEAVRLHPPFCLPFERVVPSGGLTIGGTYFPAGTVVGM
SPWVINRHRPTFGHDAESWRPERWMVPEEHRRKLEQSVLT
(0)
FGAGRRVCLGKHIAMLEIKKLTAALALNYE (0)
FDLLDPKRFKVENGWFFRQYGMDVKARKATVWEEDKKQ*
>CYP632A1 Fusarium graminearum FG03264.1
AACM01000150 FGcontig1.150_scaffold2
MTISFFATRDNKVHRFLRSRVASTYSMTSILSMESLIQDVLDLNLKKLGE
RADEGKKFEVDKTVNYYTSDVVSQLALGGMVGCVEQQKDIGGIIQSVHDG
FYFMGNLGVLPWQMFWINNPVSKWLTKNFGGDRLNGFDIFLDWLDNRVEE
RMINGLLPNQRRDILQNFIEAKDPHGQPASKEEVMIEGVNVLAGGSDTTA
FGILSCLRHLLTSPDAKAKLMEEIDHAYEELGLTKEGREISFKQAEKLPY
LSAVITESNRVQPSIQYQLPRTVPSEGAQVGDYFLPPGTTCGTSSRAVNC
SREIFGPDAEEFRPERWIAQGPDDEARIRKEKSLLMTFGMGSRSCIGKNL
AIVELHLYIAQFFRHFDAEVAKSAKPWGIKSQWLTFHHDFVITITRREH*
>CYP632A2 Nectria haematococca
e_gw1.80.13.1
Necha1/scaffold_80:8615-10329
70%
to 632A1 F. gram.
MQHLFPRSALFLLLHSKGSLVILLVGLLFFRVLYNLFFHPLRKIPGPFLARSSELWRAIRYFRGTWHDDV
LELHKTYGQVVRISPGEVSFTSPEAIKAIYGHGKNVSKAGTSPLLHSLPRNNMLMR
(2)
FFATRDNKVHRSLR
SRVSSAYSMTSILGMEPQIQDVLDLNRRKLGELADGANYIAFDKMVNYFTFDVVGQLALGGKIGFLQQGK
DVDGIIQSVSDGFYLMGNMGIFPLQMLWINNPVSKWFTKTFGGDRLNAFDVFIDWLDKRVEERMTNGLLP
GQRRDLLQHFIEVKDAQGRQADKKEVMIEGVNILAAGADTTAIGILACLGYILTNPRSKTKLTQEIDNAY
QELNIDDERREISFKEAEKLPYLSAVILESIRLHPSIQYQLPRNVPLEGAHIGEYFLPCGTTCGASARAV
NCSREIFGSDAEEFRPERWIPRSPEDGERIKSEKSLLMT (0)
FGMGSRNCIGKHLATVELYKYIAQFFRYFDA
ELANKAKPWNTKTQWFAFQRGFLVAIKRREHLADVEGPVGNC*
>CYP632B1 Mgr019 Mycosphaerella graminicola
39% to 632A1, 40% 632A2, next best hit is 30% to 5078A4
yedllow from JGI model
e_gw1.6.392.1|Mycgr3
TESVFATRNHQDHQFLRKRVFKTYSMSSILSMEHLIDEVVDLSLRQLHCHVMDNRPVRLDRWTMFFAYEVVSNLALGHLK
GFLERGEDVNNIIDSNHTGFWLNANVGYLPGQSRWFSNYYFLWVMTKLGSNFSAISDWIDGAVANGRRGHSSISRGPDLL
QHFLNMSDGGGKPVSDEEVASEIGNVLGAGADTTGILIMATIKYLIENQSDYCRLQREVDAEHRRLQLSAGQEIRYTDLA
KLPFLFAVVQESLRLHPSIVYQLPRESLKSGTTIRDQLIPPGVSISVSAAAVNRSVDVFGSDADAWTPQRWMEQNAGGGG
DSSFTLESSLMTFGRGSRGCIGKNLALVEAYKYTASFVRNFDASFIDPKKNGTVISYWFAKIEGVDVALTSRLA*
>CYP633A1 Fusarium graminearum FG03796.1
AACM01000164 FGcontig1.164_scaffold2
MAANPSGFLSFIAEDLQQSPGNYFTVLGVLFVTVLLHRLSTPSLETG EPP
LLKPKFPIVGHFYGLMKYQNVYLKQLYDKYHRQIATLPILGGKLYVIFDP
AIVQSAYRKKTLSFEPFAAEFAQRELLLSDRVQDKLKNTNLVPDFFAAIH
PAMTGDHLHRMNANALNYISKDINKISGQGSLEHANLWLWLRDLVTMATS
EALYGSKNPLRQDRSLLEDVWTFEAGLNMLLVNIFPAITAPKAHQARARL
QAALGKYYGARSYEDEDAAEIVRGRAGAFVKYGVPDEEVGHIELALLHVG
TANTIPTLYWFFANVFNRPDLVLKLREEVSQVVQKDGGNKVVIDVSILDE
KCPLLVSCYRESLRVSNQATGNRRVLEDTTVTDNKGNSYLLKKGENVQVS
AAVSHNLDAWGEDASTFRPDRFIETKDSNDAEKTRRSAFIAFGGGRNLCP
GRNFAFAENLGLVACLLAGFDVTLPDGPKLPASVDCSFAQAAVRPAKDGA
GFGVRIERRLGWQETQWSFKS*
>CYP633A2 Nectria haematococca
fgenesh1_pg.scaffold_48000021
Necha1/scaffold_48:55055-56793
55% to 633A1
This gene model seems correct
MAQNVTTASNGFLSFVAEDVKQSPARYLTGLALLLSAIFLQKLSSPGRDEREPPFLKPSIPIIGHIIGMIKHHGGYFQILF
(2)
DKTRARIGTLPILGGKLYIIFEPSMVQSAYRNKNLAFEPFAVEFAQRELAISNESARIV
RETNLVPDFFSVITKSMAGEYTHRMNANALKYVSKELEALGSNEPSKIPNMYLWVRDMMTIATTEALYGP
DNPIKGHPGLQEDLW (2)
TFEAGLTGILLNVFPSITARAAHYARARLQAALGKYYGAMKDQHEDAAQIVKSRA
GVLRSYGIQGAEVGTFELALLHVSTANTIPTLFWFMAQIYARPELVSRLRDEVVPAAQYGDDNEVTIDIT
TLDQKCPLLVSCYREAIRLSNQTVGNRRVMEDTTISDGKGNSYLLKKGLNVQMSAQVLHTLHSVWGNDVM
EFDPERFIEKGGKENQQSDRSKRTSFAPFGGGRHLCPGRNFAFAENLGLMTCLLLGFDVSPLDEDYTTFK
VPTMKACVFSEAAGKPEKEGEGFGVQIQKKKGWEKTKWRFVS*
>CYP633B1 Fusarium graminearum FG08207.1
AACM01000329 FGcontig1.329_scaffold5
MALTEGISELLLSKPVVLGLAACALLFLIGRAFEPTVDALEPPMLRPSIP
IFGHFYSMMKDQEAFFKRLDKKYHMPIATVPILKYKMYAITDPILVQSAY
CNKNLSFTPFAINGAQKVTGFDDDYHKVLMETNVLPEYFKSLYDGTTAQH
IHQLNVTSLKHVSQHINSIQENGMTIDNTYLWLRNLMTVATSYLFFHIFN
SKTLQRTKEARRRIQLALGKWCTNMRQDDERVSAYIRNRVGILRNYGVEG
QKLGDIEVGLIHVPTSNSIPTLFWFFMHVFTRPDVVEQMRAEVEHIVQRG
PDETVTVNIDDILERCPLMISAYREASRLCNGFTCNRIVMEETTITDRHG
RSYLLKKGSSVKMPAGVMHASQEVWGEDAAVFRADRFLDKGLTSEQAKLR
RAALTPFGGGAHMCPGRNFATAEIYGFMTALLLGYNVEPVDGKWDAFKPP
PMATCPQSTSVCKPEDEASVCGTRLIRRSGWEGAQWKFVSGKVTE*
>CYP634A1 Fusarium graminearum FG02872.1
AACM01000142 FGcontig1.142_scaffold2
MDSHSSSFLGQTFLDLRNGDLSSSSAWTTAAIATAIALSLLNYFLTPRLD
PREPPVVKPTIPWIGHILGIIRHQADYGRLIHNANPNHQIATLPMLNGKL
YAVFDPSLLQSLLRNKTASFEPFAIDYAKKTFDLTQEEFLKVKAPGVYDE
FTDAIHASFQTVSLHQMNVHFLACISAKLDPMSNGTMRAHADTHGKEKVT
NGQLQVENLYLWCRDVMSLATTKALYGDTDPFGSKPDLIEDMWCFEESVP
YFLLSLYPSITMPKAYKARSTLQDIVCKWYSEDHDVTDPSVSAIVRNRAG
SLRKNGLIGSEIGKFEVILPNVATLNAVPTFYWLLLYILDRPELVARIRS
EAEAAAVIAHDNGKKTVTFNIAEYEAKLPLLVSCYRETMRLVNQSVSMRR
ILEDITVTTPEGNTYLLKKGTDMQLPAGVAHYEQSVWGSDVNTFDPERFH
PGSKGSPEEERKRKAAYIPFGGGRHLCPGRNFAFAEIIGFASSLLLGFDV
EATGMGFGDMKKLGPQLAGGTVRPEKYGSGLGAQIKSRQGWGNVQWKFEC
*
>CYP634A2 Nectria haematococca
e_gw1.26.228.1
Necha1/scaffold_26:232434-234178
64% to 634A1 gap in seq after ISFGT (remove
intron 2) add back cyan region
MGVLKQDSILQGLVADLVDGNYSTAAVWITALLAGALALSLLLTPRLDPREPPVVKPTIPLVGHIIGIIR
HQSDYHRIIH (2)
NANPTKPIATLPMLNGKMYTIYDPHLVQTALRSRIASFEPFVIDFAQKTFSLSKETFAKV
RGPNVFNDFGDAIHSSFQAPMLHKMNVHFLASISAKMDPISFGTVRVDEVNSGRE
ELVDGGLRVENLYLWCRDVMTLATTKALYGDHDPFGPQPHLVDELW
(2)
LFEESVPYFLLSLFPSITMPKAYRARSMLQALMGKYYTEEHDINDPTTSQ
LVKNRAGALRKHGFTGNEVGQLEVILPNVATLNAVPTFYWMLLFIFERPELVNRLRKEVEAAAVVSNSEG
KRTATFDIASFDARLPLLISCYRETMRLSNHSVSMRRIMQDMTITGADGQSYLLKKGVDLQLPAGVTHHD
RSAWGKDFDEFVAERFLQKAGDAETERRRKAAYFPFGGGRHLCPGRNFAFAEILGFMAVLVLGFDVEPLG
MRFGEMKMLGGQLASGTVRPEKHGKGLGGKITRRSGWDDVEWRFEC*
>CYP634A3P Fusarium oxysporum
75% to 634A1, pseudogene fragment, no upstream
P450 seq.
FOXG_12544, FOXG_12594, FOXG_17081, FOXG_13997
ARIRAEAENAAVVEEKNGKRSATFNIAEFEESMPLLVGCYRETLRLVNQTLSTRRILQDTSVTTPEGATYI
LKKDTDLQLPAGVAHYEDSVWGADVNVFNPERFLPSSKGSTEDERKRKAAYIPFGGGRHLCPGRNLA
(?)
AEIIGFASALLLGFEIEAVGMGFGNVKMLGPQLAGGTVRPERYGAGLGAEIAMRQGWEDVEWRFEC*
>CYP634A5 Fusarium oxysporum
75% to CYP634A1
FOXG_15710
MTSQSLLTSLVDYRGGNVTILSTTVLAVIVAFSLLNRLLTPRIDPREPPVVKPSIPWVGHIIGIIRHQADYSRIIHNENP
HVQIATLPMLNGKVYAAFDPALLQTLLRNKTASFEPFVFDYAKKTFALKHETFAKVKVPGVYDEFTEAIHASFQVRHLHQ
MNVHFLGSIAAKLNHATIRADSINAGKETVANGRLHVKNLYLWCRDVMSLATTRSLYGDTDPFNRDPSLIEDMWLFEESV
PYFLLSLFPSITMPKAYKARSTLQNIACKWYSEDHDIHDPSVSALVRNRAGALRKNGLTGYEIGKFEVILPNVATLNAVP
TFYWLLLYILDRPDLLARIRAEAEGAAVIEDNNGKRSATFNIAEFEEKLPLLVSCYRETLRLANQTLSMRRILEDTSITT
PEGTTYILKKGTDLQLPAGVAHYENSVWGADVNVFNPERFLPSSKGNFEEERKRKAAYIPFGGGRHLCPGRNLAFAEIIG
FASALLLGFEIEAVGMGFGDVKMLGPQLAGGTVRPERYGAGLGAEIAMREGWEDVEWRFEC*
>CYP634A5 Fusarium verticillioides
93% to CYP634A5 Fusarium oxysporum
FVEG_13169
MNSQSLLTSLVDYRVANVTILSTTVLAAIVALALLNRLLTPRI
DPREPPVVKPSIPWVGHIIGIIRHQADYPRIIH (2)
NENPHVQIATLPMLNGKVYAAFDPALLQTLLRNKTASFEPFVFDYAK
KTFALKQETFEKVKVPGVYDEFTEAIHASFQVRHLQQMNVHFLGSIAAKLNTATIRADAINAGKE
TVTNGRLHVENLYLWCRDVMSLATTRSLYGDTDPFNRDPSLIEDMWLFE
ESVPYFLLSLFPSITMPKAYKARSTLQNIACKWYAQDHDIHDPSVSALVRN
RAGALRKNGLTGYEIGKFEVILPNVATLNAVPTFYWLLLYILDRPDLLTRI
RAEAEDAAVIEENNGKRSATFNIVDFEEKMPLLVSCYRETLRLANQTLS
MRRILQDTSITTPEGTTYILKKDTDLQLPAGVAHYEDSVWGADVNVFNPERF
LPASKGSAEDERKRKAAYIPFGGGRHLCPGRNLAFAEIVGFASALLLG
FEIKAVDMGFGDVKKLGPQLAGGTVRPERYGAGLGAEIQMRRGWEDVEWRFEC*
>CYP635A1 Fusarium graminearum FG08191.1
AACM01000329 FGcontig1.329_scaffold5
MSLTSNSKQRKEPIVTLPMLNGKLYVINSPDLIQAALRNNDISFTPFILE
SSKAMWGLSDNAMASISDLANLKGGMQIIHSTLGGESLHKLNISSLSRFM
TYLNRVKPGENIGIADTYIWLRDMLTDASATAVYGPKNPITVDKMHLVWY
SLLQSIYSTCSNSGRDYDKQALLVAIGLPSFVTKAAINARLKVNNLLLSY
YKNGGNHEKGASEIIQQRATYLRKTGFTDDDLSHMEFMILWVGVTNTAPV
LFWLFVHVLTSAGYTSRVRAEIEAITIITKTPEGRKATFDTRLLEKSCPF
LNACYQECLRHYSHSIGNRRVMQDTEIQDSQGRKYLLKKGVNVQWPPPVT
HFNTEVWGQDADVFRPERFMDVTPQDEKKRRGALLSFGGGKHLCPGRKFA
YTELLGLVGVVALGFEVKGLELPESKYAGIGIGGKMPDWENMEKGFGLRR
REGWEDVTWVFDGDN*
>CYP635A2 Nectria haematococca
e_gw1.25.117.1
Necha1/scaffold_25:315985-317594
52% to 635A1 gap after HLLW but this seems
correct. 635A1 may be too long
here
MSTAGLAVALTGLLYLLKACLFPTMDPLEPPLLKPRVPIFGHIISMMREKAGFYTRLF (2)
KERRMPICTLPMLNGKLYVINSPSLIQAALRNNDISFDPFIVEFSKGIFGQNERQVEVIARPTVMKDLLDIIHSSLLGEPLH
RLNVVALEKMMGHINVIQPNESVAIPDAFIWIRDMTTEATAVALFGKKNPITPEHVHLLW (2)
TFDKSATLLAINVAPNLIAGESVAARSELNKLFLPFYEARCEEGPDVSDIIRKRTAVLRAAGYNDQDLAVQELMLPWVGS
TNTIPTLFWLFVNLFARPGYLERVRAEIEAITTIEDGPNGRTALVDSTKFEKHCPVLNACYQETLRMYLH
SVGNRRAMKDTKIQDLDGREYLLKKGTNVQWPPGVTHFIDTVWGNDADTFNPERFIKPTAQDERARRGAL
LPFGGGRHLCPGRKFAFAEILGFTGVLALGLTVEGLDLPDSTDPIFGSAPRRPVWGANGPGFKLSRRPGW
EDVTWTFKK*
>CYP635B1 Nectria haematococca
fgenesh1_pg.scaffold_35000113
Necha1/scaffold_35:263720-265404
46% to 635A1 gap after LHLI, this seq seems
correct, 635A1 may be too long
This gene model seems correct
MAAAGQSVPMGASSTSVSARWLFGGEKTPSAVVLTAAIILPLLFVGL
KKLLYPIFDSREPPVLRPRIPFIGHIVDMIRERSSWYIRIY (2)
KENPLPICTLPMLHGKMYVINAPDLITAAMKNGDISFDPFLLEVPVGLFGLSKKLSDIIEQRHVIDGLLN
VIHYTLMGDHLSRMNITALTKMMETLNDVGPHPVELSDVYEWSWDVLGNATMVAIFGEKNPLTPEHLHLIR
(2)
DFDEGIARFAIGVAPRLIAPGPLRAREKINTLLESFYAAGYETRPDVSSII
QKRTEILRREGFNDRDLGIQEITIPWVATTNTIAVLYWLFAHVFSVPEYTQRIRDEMEAISVIANTNEKG
RVGTISVKEMNKECTFLYACYRETLRLYIHNTGQRRVVKDTTIKDQGGREYLLKEGINVQWPGSLTHMTD
SVWGDDAWTFRPERFLEVSPQEEKQRRGAYIPFGGGKHLCPGRNFALSENMGFVGILALGYNIEGVRVPK
SEDPGIGLGSRKPIGGAALRSAKVSRRVGWEDVTWEFVE*
>CYP636A1 Fusarium graminearum FG02111.1
AACM01000111 FGcontig1.111_scaffold1
MGVNNATLGLVCCVIVAVVALATRKGPDSREPPYVKERVPYFSHIYGLLK
HGLRYFDVVSAQQPHPIFTIDMSGQKNYIVTSPELVQAVQRNTTSLSFSP
AMIPAFRRMMGFDEAGIELIFRDAHTEKGMYGEIHRVQKASLLPGTESLD
ELCTIIRGKLLTIVNDMPSSQTIDLYAWVQDLYMRTNNSACFGAKDPFTL
NPSLISTFWLWEANIKVLLLGIPWFLSPSKYSTAQRTRNDLVNAFTQYLG
NDGLETACSFIKELSNLGIRRGLSTENNARALVGSILAIVGNTIPTTFWL
LIQIFSRPDLLKEIRSELEATLEDPSSRSEISLNYTVIREKCPVLMSTYE
EILRMTSGIATVRYTNEDTLIQDRWLLKKGAQVQMPTAFIHADPTTWGAD
AEVFDHTRFLKSKVLTKEQKARRAAAFRPFGGGNTLCPGRHFASYEVLTF
AGSILLGFDMTPTTEAFNLPEMDRSKLPLTSLKPAGDIKVNLTRRSGWEK
VQFK*
>CYP636A2 Fusarium oxysporum
86% to 636A1
FOXG_04458
MALSNLTIGVVCCVVVAIVALATRKQPDAREPPYVKETVPYFSHIYGLLKHGLRYFDLVSAQQPHPIFTIDMSGQKNYIV
TSPELVQAVQRNTTSLSFSPAMIPAFRRMMGFDEAGIELIFRDAHTENGMYGEIHRVQKASLLPGTESLDELCTLIRTKL
LNIINELPSSQTIDLYAWVQDLFMRTNNSACFGEKDPFTIDPSLNSTFWDWEANIKVLLLGVPWFLSPKKHSTAQRTRKE
LVDAFLKYLNDDGLDTACSFIKELSGLGIRRGLSNENNARALLGSILAIVGNTIPTTFWLLISIFSRPDLLKEIRSELEA
TIEDPASEIVSLDYTTIRERCTVFMSTYDEVLRMTSGIATVRYTNEDTLIQDRWLLKKGAQVQMPTAFIHADPTTWGADA
DVFDHTRFFKSKVLTKEQKIRRAAAFRPFGGGNTLCPGRHFASYEVLTFAGSILLGFDMAPTTKTFNVPQMDRSKLPLTS
LKPAGDIKVSMSRRPRWEKVQFR*
>CYP636A2 Fusarium verticillioides
92% to CYP636A2 Fusarium oxysporum = ortholog
FVEG_07578
MALSNLTIGVVCCVAVAIVALSTRKKPDAREPPYVKETVPYFSHIYGLLKHG
LRYFDLVSAQQPHPIFTIDMSGQKNYIVTSPELVQAVQRNTTSLSFSP
AMIPAFRRMMGFDEAGIELIFRDAHTENGMYGEIHRVQKASLLPGTESL
DELCTLIRAKLLNIVNELPSSQTIDLYAWVQDLFMRTNNSACFGEKDPFTL
DPSLNSTFWAWEANIKVLLLGVPWFLSPKKHSTAQRTRKELVDAFLEYL
NDDGLDTACSFITELSGLGIRRGLSNENNARALLGSILAIVGNTIPTTFWL
LISIFSRPDLLKEIRSELEATLEDSSSGTISLDYNTIREKCPVFMSTYDE
VLRMTSGIATVRYTNEDTLIQDRWLLKKGAQVQMPTAFIHADPITWGADA
DVFDHTRFLKSKVLTKDQKTRRAAAFRPFGGGNTLCPGRHFASYEILTFVG
SVLLGFDMAPTTKTFNVPQMDRSKLPLTSLKPASNIKVDLLRRRGWGEARFR*
>CYP637A1 Fusarium graminearum FG03498.1
AACM01000159 FGcontig1.159_scaffold2
MLREILYGAAGLVLFAYTLEWLFSMSDDPREPKRLQSKIPVFGHLIGMMK
YSSGYHGITSKQTDQEIYTVAIFNTKLYVAKTARLIPLIQRSKTLSFRPF
MQTAAKHMGDAKPATFEIFGSEWVDSFSHAHKHSLAPGPSLDEQNSRMGD
RALIDIEELLPREKNGMNKVSLLEW
VRYAVVQASACGILGVEHPFRDPKIDAAFW (2)
KWQDYMPLHLINLD
ITKKGYAAREIVFDAFRKYNTNIPTDVSAVYMARQRTMQEAGIDEDDICK
QQATFGTAAFANTVPILYWTIYELFSRPELLEEVRREVIEHAVSRNKETG
FVVDVAALKTQCPLLLSIYQETQRTRHVHANIRKVTEDTLLDDKYLLKAG
QFVMMPGHPVHTNQTTWGESADVFDPYRFMPKDGSDKKAIASSSFMAWGA
PPHLCPARQFASTEILIVVALLVVRCEMSPASGQWVRSPTLNTGDMATIY
TPKKDVELEVRRTEEWDGEWSLRMGGSKTRVSLASG*
>CYP637A2 Fusarium oxysporum
78% to CYP637A1
FOXG_16528
MFREIVYGVAGFVLLAYAAEWILSLFDDPREPKRLQSKIPLFGHLWGMMKYSSGYHGITR
(2)
SKQTNEEM
YTVAIFNTKLYIAKTSRLIPLIQKTSKTLSFRPFMQTAAKLMGDAKPETFEVFGTEWVDSFSHAHKNGLATGPFLDEQN
LRMGDRALIDIEQLLPVEKDGVAKVNLLEW
AQYAVVQASACGIFGVEHPFLDPKVDQAFW (2)
KWQSYLPLHMVNLDITGKGY
AARQIVFDAFRKYNKNLPSDVSFIYKERLRSMQEAGIDEDDICKQQATFGTAAFANTVPIMYWTIYELFSRPDLLEEVRK
EVIEQAVSGDKESGFKVDVAALKTKCPLTLSVFQETQRLRHVHANIRKVTEDTLLDGKYLLKAGHYVMMPGQPVHTNTST
WGPTADQFDPYRFTKDSSDRKA
SSFVAWGAPPHLCPARQFATTEILIVIALLAVRSDIAPVKGEWVKNPALNTGDMATVY
TPKKSVEVEVRKRDDWDN*
>CYP637A2 Fusarium verticillioides
97% to CYP637A2 Fusarium oxysporum = ortholog, C-term is
extended
FVEG_13702
MLREAVYSIAGFVLLAYAAEWILSLFDDPREPKRLQSKVPLFGHLWGMMKYSSGYHGITR
(2)
SKQTNEEMYT
VAIFNTKLYIAKTSRLIPLIQKTSKTLSFRPFMQTAAKLMGDAKPETFEVFGTE
WVDSFSHAHKNGLATGPFLDEQNLRMGDRALIDIEQLLPTEKDGVSKINLLEWAQ
YAVVQASACGIFGVEHPFLDPKVDQAFW
KWQSYLPLHMVNLDITGKGYAARQIVFDAFRKYNKNLPSDVSFIY
KERLRSMQEAGIDEDDICKQQATFGTAAFANTVPIMYWTIYELFSRPDLLEEVRK
EVIEQAVSGDKESGFKVDVAALKTKCPLALSVFQETQRLRHVHAN
IRKVTEDTLLDGKYLLKAGHYVMMPGQPVHTNTSTWGPTADQFDPYRFTKDSSDRK
ASSFVAWGAPPHLCPARQFATTEILIVIALLAVRGDITPVKGEW
VKNPALNTGDMATVYTPKKSVEVEVRKREEWD
GEWSLRMGESKTRISLASG*
>CYP638A1 Fusarium graminearum FG02114.1
AACM01000111 FGcontig1.111_scaffold1
MSILNSKLSFDLNSTTMKMNHWLETSPMAYILLSLLVLLFSTYFITTVRF
SLQRLSNRRYQGKEPSTLPYGVPGLGSALGLIRNPHGFFGSIVKNFDSGE
PIRMRLGLDHY YLIHGTRSVQHVFRCSKELTFEEFALRVAHKVKRLPERD
VALCSADKSGSARVPLIEAREEDRIWRKFHELYEHHLIGSSAVSGLTELF
VGLMNNELSTIALDGPIEVGIDHFLRKHMFRASTIALAGHGVFEVDPNFA
DVFWEYDVDFMPLLYGLPKIMCRKGWNARDKCLETTKTYLGNAWRNLDWR
AASEMNPEWEPNFGSRLVREREVAMEKYGLSLEGRASFQMGLIWSINSNA
IPMTSWIIIEILRRPEIFKRIKEEVATVFDKETKNIDIAEVRKLPLLNSV
YLECMRLRSSVFVVRKLRESIDLDGYTLKKGNLILAPSYLAHSAPEVWSS
GAHPPEEFWPERFIQKGSAGITAGNYFPYGGGVAMCPGRNYAKQEILAAA
TLFFAHFDAEPLRFVDDNGKTSDRGPEVGNEARG VARVDRDMVVRLWRA*
>CYP638A2 Fusarium oxysporum
77% to CYP638A1, one frameshift
FOXG_04461
MMDAPFFNASAST
IALVAVLLLLSTHCITTIRYSIQRFCDRRYQGKEPSTLPYVLPGVGSALSLIRNPHGFFNSIV
(2)
QKVENGEPIRMRLGNVHAYLIHGTRNVQQVFRCSKELTFE &
EFALRVAQKVKRLPAKDAALVAKDISGSSRLPLTETREEDRIWRKFHEIYESHLIGANAVSALTELFIDTMIDELGTAA
TQGPIEIGIDEFMKHHMFRASTIALAGRKVFDIDPNFADVFWDYDEDFMSLLYGIPKFLCRKGSNARDKCLETVKGYLDQ
GWQNLDWRACHEQNRDWEPNFGSKLVREREVAMEKYGIGLDGRASFQMGLIWSINSNAIPMTSWIIIEILRRPEIFKRIQ
EEVATVFDKDTKQVDIVALKKLPLLNSVYLECLRLRSSVFVVRKLRNSIELDGYTLKEGNLVLAPSYLAHNAPEVWSSSA
HPPEEFWPERFIKKGNSGISAGNYFPYGGGAAMCPGRNYAKQEILSAVVLFFAHFEIEPLRFVDREGKTSDRGPEVGNEA
RGVARVDRDLLVRLQRV*
>CYP638A2 Fusarium verticillioides
94% to CYP638A2 Fusarium oxysporum = ortholog
FVEG_07581
MMNAPFLNTSASSIALVAVLLFLSTHSITTIRYSVQRFCDRRYKGKEPSTLPYVLPGVGSALSLIRNPHGFFNSIV
(2)
QKVDNGEPIRMRLGNVHAYLIHGTRNVQQVFRCSKELTFEEFALRVAHKVKRL
PAKDAALVAKDISGSSRLPLTETREEDRIWRKFHEIYEAHLIG
TNAVSALTELFINTMIDELSTVGTQGPIEIGIDEFMKHHMFRASTI
ALAGRKVFDIDPNFADVFWDYDEDFMSLLYGIPKFLCRKGSNARDKCLETVKGY
LDQGWKNLDWRACHQQNPYWEPNFGSKLVREREVAMEKYGIGLDGRASFQ
MGLIWSINSNAIPMTSWIIIEILRRPEIFKSIQEEVATVFDKDTKQVDIV
ALKKLPLLNSVYFECLRLRSSVFVVRKLRNSIELDGYTLKEGNLVLAPSY
LAHNAPEVWSSTTHPPEEFWPERFIKKGNSGISAGNYFPYGGGAAMCPGR
NYAKQEILSAVVLFFAHFEMEPLRFVDRDGKTSERGPEVGNEARGVARVDRDLLVRLRRV*
>CYP638B1 Histoplasma capsulatum G217B
ABBT01000036.1 Ajellomyces capsulatus G217B
38% to CYP638A1, ony 25% to next best hit
HCB00815.1 revised
65285 MLTFAAFILAVFVTYLFTLCRFHFQLRKNQRGQRQNPASLPYLLPWIGNGFQFACYPHALFHFAR
(2) 65479
ARLGPSH
MYIITGAEYVKAAFGSSKNLTFDSRTIQIMEQVYGLPAGDAAPYKHSPGKAKELVSKLDQLYIANLANRECTAAMIRQFV
KSLNAQVGCLRNDKGTEVMIGTCLRRLMATASISALFGDAIIEKNATFVQDYWIFSKDFKRLLYGMPKLFCRKGVHARDR
MLKAIKAFILDALQDDVREMEPKSPTVESSPPYVSLVVRETNKFFTEAGFSVEGRASEALSLVFAINDNAIPTTIWMLLE
ILKSPGLHKQIYEEVQTSVVPDQNGNGRNCLDLSKLLTLPLLNSLYSECLRYHLSAQLARHLKNDIEIDGYLLKKGNLVV
APTLTAHREPEVWFRPNHLPSEVWPERFLHVRNIKPSNYFPYGMGAISCPGRVYAKTVILTSVATMLLTFDFEVLGFVDD
KGKACHRAPKPVAQGMGVSLPDREPLVKLKPRFSQGIM*
>CYP639A1 Fusarium graminearum FG03850.1
AACM01000166 FGcontig1.166_scaffold2
YGIYICLFILPFLVTYAFTVLGNTGYRDGTAAREPPKVPYWIPFVGNTIG
FAYDTERFLFSSLRKFGKVPLRIFVGAEQMYFIPHGQTIVELFKSSRYLT
TKTFGIMTVRDAFGLPQPDVEIYAGDNSGVDVKPAPGWEHVEQAKRFHFV
QHRQLNAYLSGNALNAIISKFTEGYSDQIAQDTTFQEDGWVEVDDLYGWF
KNHLLRATTVALCGEKFLELSPDFLEDFWSFDYHLPNLFRRLPRWVVPKS
YQARDRLLECLLRYHEYGQQNLDFTDQKLLEKDWTPEFGAKIMSTRQEMF
KNIGLSPRGGAALDVGMIWAVNANAIPAAMWMLLGILLDKNLTDRVMAEM
EPSFHEKSLSFDNDRLCSGPLLNSVYLEVLRVRVAAPVGRSSLIPNLKFG
KWQMKQDVGMLSTSWFGGHDPDFWNTGSTLPDGSEEHPVDTFWAERFLKY
EDDPTGGPVRNTNVKPSTRPSKRTADDDRKASVFTEGTQGYFYPYGGGTK
MCPGRFFAKQKLMAGVALSLRAYEIELVDPEAAAKVGPNMDYFPFGTIPP
KGKVPARIRRRKL*
>CYP639A2 Nectria haematococca
fgenesh1_pg.scaffold_25000008
Necha1/scaffold_25:22167-24012
64% to 639A1 some difficulty in mid region, gap
after LRYH
MNATAITATASFVAETSSYGKVLVFLVLPCLLTYAYTSYGNRGYRHDLASREPPRVPYWVPVVGNTFGFA
FDTEKFLFSAI (2)
SKFGNVPLRLLIGAEPMYYIPHGQPILDLFKASRHLTTKSLGVMTIRNAFGCPPADVKI
YADDESGTDAKPAPGWEHVDPSQRLHFVHHRDLHTLLAGSSLHALEEKFVESLSRSISNDSKFKKDEWTE
VSDLYVLFRDYLFCAALEAFCGEKFLELSPDFPENFWVFDHHLPNLFKRLPKWLIPKSFRMRDKALGGVL
RYHRYGREQFDFTDDNVLKGEWTPQFGSRLMRARQKMFLTTGFSVQGAAALDLGI
(2)
VNANAIPASMWMLLGVLLDDNIKDRLMAEIDPAFTTSSLSFNKDKLCSGPLLNSIYCETLRVRVAA
PVGRTSLIPDLKFGKWKLNQGVTMLSTSWIGGHDTKFWNTGREFPDGSVEHPVDSFWAERFLQYPDDPSS
GPVRNPSFKAPFKTKRRTPEDDRNAQVITEGTQGYWYPYGGGTKMCPGRFFATQELKVGVAIMLRAYDIE
LLDHEAAAKIGPNMDYFPFGTIPPNGKVAARIRRRKLE*
>CYP639A3 Fusarium oxysporum
69% to CYP639A1 Fusarium graminearum
FOXG_17188
MNATETAAANPGSATEAISYFKVLSLVVLPFIVTYVFTSFGNKGYQHGQSAREPPRVPYWIPYVGNTIGFAFDTERFLSS
ILSKFGKVPLRIFVGAEPMYFIPHGQPIIELFKASRHLTTKSLGVMTVRDAFGLPESDMPIYVDEDSQFGHVDPLKRFDF
VQHRDLHALLTGGPLNSMTAKFVEVYSDIIEKDTRLNEDDWTEVDDLYEWLKNNLLRAAITALCGDKFLEISPNFLEDFW
LFDYHLPSLFKRMPRWLVPKSYAARDKCVESMLRYHEYGNQLFDFTDEDGVVKKDWTSEFGTRLMSARQKMFQSVGMTPR
GGAALDLGLMWA (2)
VNANAIPAGMWILLDILLDKDLKDR
VMAEMQPSFIDKSLSFDIDKLCSSPLINSIYLETLRLRVASPVGRTSIIPNLKFGKWQFKKGVGMLSS
SWVGGHDPDFWNTGHVQPGGVEEHPVESFWAERFLVYENDPASGPVRPTASAEKPAKRTSEDDRKARSTIDGTQGYWYPY
GGGTKMCPGRFFAKQELIAAVAVALRAFDIELVDPEAASKVRPNMDYFPFGTIPPKGKVAARIRRRKL*
>CYP639A3 Fusarium verticillioides
90% to CYP639A3 Fusarium oxysporum = ortholog
FVEG_12894
MHQPMSASNLNPLNASRRFTMNAKTAAANPASATETTTYLKLVSLAIL
PFIVTYILTSFGNKGYQHGQSAREPPRVPYWIPYVGNTIGFAFYTEGFLSSI
LSKFGNVPLRIFVGAEDMYFIPHGQPIIELFKASRHLTTKSLGVMTVRDAFG
LPECDMPIYVDDDSQFGHVDPLKRFDFVQHRDLHALLTGGPLNSMTAK
FVEVYSDIIEKDTKLSENEWTEVDDLYEWLKNNLFRAAVTALCGDKFLEI
SPSFLEDFWLFDYRLPSLFKRMPRWLVPGSYAARDKCVESVLKYHEHGNK
LFDFTDEDGIIKMDWTPEFGTKLMSARQKMFQSVGLTPRGGAALDLGLMW
AVNANAIPAGMWILLDILLDKDLKDRVMAEMQPSFIDKSLSFDIEKLCSG
PLINSIYLETLRLRVASPVGRTSIIPNLKFGKWQMKQGVGMLSSSWAGGH
DPAFWNTGHVQPGGIEEHPVESFWAERFLVYENDSTSGPVRPTAAAEKPT
KRTSEEDRKARPTIDGTLGYWYPYGGGTKMCPGRFFAKQELMAAVAVALR
AFDIELVDPEAASKVRPNMDYFPFGTIPPKEKVAARIRRRKL*
>CYP640A1 Fusarium graminearum FG11108.1
AACM01000459 FGcontig1.459_scaffold8
MESMIITPEMNSTLKIADVQAHDLPLQHNFLSYLFGLLIATYIVWQYFLR
TGVTESACSEPPMLPYWIPVVGHTFSFLTNTHNTIMSGRSHFKSITHPFS
LLIGGRRTYVVLDPHYIGKVYKKTKDLVHEPFIDHLMMCIGTTQKTRDIM
WNTMIGDSSLTDSALDWLREEVSQSPSSQPFFDRFMMELDHGLQQGDPLT
TGRLREHNMLKFVETIIITVSTNSFFGKVLLKQSPEILDSFPIFDRHVWK
MVFRAPKFTFMTAHNAKGSVIDGLTKYFDLPQSERQDAASFILKSEDAMR
ENGICSREIAALLFKFFWGINGMPATLAFWFLARTVYTPHLWEDIRAEVA
PAFRNGIHSPPDIGYLKKCPKLNATFHETLRIHGGTAGFRQVASDTVIGG
FTFKAGSDVIMPYRQMHLDEGIW
GQDAKTFDIDRFIHNPKLATAKTFK
PFGGGVTLCPGRFHAHRTALSFIAIVITRYDI
HVVGGCESRPFPHMNTRGPEVGVIFPVLEQVPQIIVKNVDIE*
>CYP640B1 Fusarium oxysporum
47% to CYP640A1
FOXG_13207
MSAITVTPGVNATIGVVDTEGPVFTLHYQILFRVLGTCLVAYVAWLYLLRIGALWNSQLEPPMLPYWIP
(1)
GIGQNISFFIDVEKLLVAARLVLTGLSITV (0)
PFSVLIGGRRTYVILDPHDIAETHQKTKELQFDAYIDQFMEYVSVSKK
ARDILWGTTLSETSLSVPNSLRSWIRADMTQT
SSRKFYSEVLLELDSVLQQGSPFTTGKSSEHDMLKWTSDIIVKASTKSFFGNALFEKSPGLVDHFRRFNRQTWKLL
YKYPRFLSRTAYDSRDSAIDGLERYFKMPQDQRGDAAPFVIKAEDEMRKHGISDRDIAAVLFKLYWAINGNPSVLAFWLL
VRTLYTPNLKEDIKSEVAPAFKNGIHHQPEIEYLKECPKLNATYYEAMRLHSGSSSFRRVVQDTTIAGFQLKAGNDVMMP
YRQLHLNKKYWGENAENFDIDKFVDNPKLHSARTYKPFGGGTTFCPGKLLARQMALVYLAILVTRYDIEIIGGCEGQPFP
EANDKAPTLGIISPKPGHDVKILVRDVS*
>CYP640B1P Fusarium verticillioides
68% to CYP640B1 Fusarium oxysporum
no gene model, supercontig 19 373448 – 373945 region
IRADMTQTSSRKFYSEVLLELD
YPRSRSV*DSRDAAIDSLEWCFEMPQD*RRDAALFVIKAEDEMRKLGVSNGHISAVLCKLYQA
INGNSSVLAFWLLARSLCTPHLMEDIKRGVAPAPK
EGIHHQPDVE*LKECPKLNATYYETKPLHSGSSSFRRLVRDTHITIAGLRLKTGNDVIM
PYRQLQLDKKYWGENS*HLDIGRFIDNPKLYSTRECKLFGGGTTLCPEMTLSAASVYL
ATLVTLYEIQPVQRCESQPFPEANDKVRMLGIISPEPGYDVKVSMRYV
>CYP641A1 Fusarium graminearum FG10910.1
AACM01000454 FGcontig1.454_scaffold8
MDSLEALRAYLNENLIPHAQRYPLQAILVTTIVLFITTRLFTGSPSSVRK
DGSKTPPLAPFWIPLFGHAPRIFLNPSAALTRFRNRYGQGVFSVRLFQSI
HSFVFRPSLAARLLEQPDSVADKEFITRHIMMTNFGLSKKDLAAYDKAAG
EVYQVTKEHLSGSHLDDLAKATLRDLDDNAADVISFNCYSTDQMDWERLA
NAELLEDIKDENIMAVDFFELIKTFIARTATISVFGTDFVEAYPDIWPHL
WIFNNGFHSLAMGVPVWAPFPTSQRARIALGRLLTFMREFHDEFETFLSG
EEPGQKWQDFHTVSPLVRARAEVYRKHGLSSDVRAAFDVSLLWSTTVQTT
SLVSWSLFELYQDPVLLSQIREQITPCVQIVQPNHDFGGAVWIPPQIKKL
DLEGLLTKCPLLQGVYLETLRLYGGGWSARYLKEDFTLKDKEDSFVLKKG
TFAHVINNLHHSDPRCFTDSKIWQAGRYLEDTVDKKGVKTQKVDPYTVKA
SDGTLTMCDDSEFTLRKVLMYVSVFISLYDLQPAGSESWPSPSIVKGVAS
VQPWSSLRLWVKRRTPPKDN*
>CYP641A2 Nectria haematococca
e_gw1.11.569.1
Necha1/scaffold_11:397275-399029
64%
to 641A1 F. gram.
This gene model seems correct
MNGLEAVRQRLEENVVPHLKETPLLAAIVTVLVLVVTTRLFTGGSSSQNGSRSPTLAPYWIPFFGHAPRL
FLSANFTLTRFRNRYTQGIFSIRLFQSIHSFVFRPSLAAKLLELPESVADKEYVARRLMVSNFRLSKNDL
EAYDKAASEVHQITKQYLSGSHLESLVKANVRDLDDVAAELVSFNSYQTDQMEWEKMAEADVVETETKER
VMEADFLELMRNFVARSATASVFGTDFVENFDDIWEHLWVFNDGFLSLAMGVPLWAPLPTSQRARIALGR
LHSFMREFHEDLDKFLNNEEPGMRWQDFHTISPLVRKRTEVFRKHNLSIEIRASLDVALFWSVTAHSTSM
VSWSLFELYQDPVLLEQIRDQVAPFVHVVQPKNEFGGVVWVPPKIEKLDMEGLMTKCPLLKAAYLETLRL
HGGGWSARLLKEDVVLKDEGEAGYVLKKGTFAHVVPDLHRTDPKAFSDQRIWHVGRYLEDDVDSKGTKIQ
KVNPKTVQAS (1)
DGTLTMCDDSDFTMRKVYMYTSVLISLYNVEPKKGGDWVTPTLVKGVASTRPSRSIRLWIKPRALPKAK*
>CYP641A3 Fusarium oxysporum
84% to CYP641A1 Fusarium graminearum
FOXG_12845
MDRLEALLERLNETLIPHAQRYPLQAILVTTIILFITTRLFTGSSSSSRKDGSKTPPLAPFWVPLFGHAPRIFLSPSSAL
TRFRNRYAQGVFSIRLFQSIHSFVFRPSLVARLLEQPESVADKEYVARRIMMTNFGLSKQDLAAYDKAAPEVYQITKEYL
SGSHLDTLAKATLRDLDDNAADAISFNSYPTDQMDWERQANAELLEDTGDEKIMAVDFFELMKTFIARTATISVFGTDFV
EIYPDIWSHLWIFNDAFHSLAMGVPVWAPFPSSQRARIALGRLLTFMREYHTELDKFLSDEEPATKWQDFHTISPLVRAR
TEVYRKHGLPIDVRATFDVALLWATTVNSTSLISWSLFELYQDPVLLSQIREQITPFVKIVQPKNDFGGAVWIPPQVQKL
DLEGLVTKCPLLQGVYLETLRLYGGGWSARYLKEDVILKGKEDSFVLKKGTFAHIVNDLHHSDPRSFTDAKVWQVGRYLE
DTVDKKGVKTQRAEPCTVRASDGTLTMCDDSEFTLRKVLMYISVFISLYELEPAGSERWPSPSVVKGVASAQPWRSVRLW
VRRRSPQPQ
>CYP641A3 Fusarium verticillioides
93% to CYP641A3 Fusarium oxysporum = ortholog
FVEG_11589
MDSLEALRERLNETLIPHAQRYPLQAILVTTIILFITTRLFTGSSSSS
RKDGSKTPPLAPFWVPLFGHAPRIFLSPSSALTRFRDRYVQGVFSLRLFQSI
HSFVFRPSLVARLLEQPGSIADKEYVARRIMMTNFGLEKKDLAAYDKAAP
EVYQITREYLSGSHLDTLANAALRDLDDNAADAISFNSYPTDQMDWERGA
NAELLENTGDEKIMAVDFFELMKTFVARTATISVFGTDFVEVYTDIWPHL
WIFNDAFHSLAMGVPVWAPFPSSQRARFALKRLLTFMREYHTELDKFLSD
EEPATKWQDFHTISPLVRARTEVYRKHGLSIDVRAAFDVALLWATTVNST
SLISWSLFELYQDQVLLSQIREQITPFVKIVQPKNEFGGAVWIPPQVQKL
DLEGLVTKCPLLQGVYLETLRLYGGGWSSRYLKEDVILKDKEDSFVLKKG
TVAHIVNDLHHSDPRSFTDAKVWQVGRYIEDTVDKKGVKTQKVDPYTVRA
SDGTLTMCDDSEFTLRKVAMYISVFISLYELEPAGSERWPSPPVVKGVASA
QPWGSVRLWAKRRSPQPQ*
>CYP642A1 Fusarium graminearum FG01583.1
AACM01000081 FGcontig1.81_scaffold1
MFDHTRTLNHISSFSLNIIPTLIFFLVAAYVLPIITRRLLRYVASPTSFS
EKSSGHGTPSISNLPHLSGVVPWLGHLMGLTIDSTRYINSLIASTTAPIF
TINIPFARITVCHPSMDRVLSRHVNDTGLAQVLVYVGPRLFGLKQDTIKA
VFGYNPQPLHKQKFGHAENIVSLNQRSSTNIRDRVAKMPEVNELLIGRWV
FELAVSATASAVWGVANPWSMDQEFSNEFMKLSETFDTLGRPFSWLTANS
AWKSRKFLLKRLREFHLQHREARVQTTGHSINVVASSDPDWENNPDYYHI
EMVSALGLLATTSTLAVWLTRHLLTDPDLVKFVLKEVEQVKYVEEDEDKP
RLDFANVRSECPWLMASWYETLRLHMTGVARIARHDFMLNIPGSEPIAVP
QGEIFMLPMCASNLDVDVWGLDAAVFKASRFIDKEGQVSGSAVRKVRAFG
VAGNMCPGRVFGTDIVFSVIGTMLRTFDIEAAPGEEFRVPTLRGGFNVGF
ERYGDDVKVLLKRKHTA*
>CYP642A2 Nectria haematococca
e_gw1.47.68.1
Necha1/scaffold_47:131858-133483
56% to 642A1
This gene model seems correct
MAVAVDVFAFLGYKTEFLNGRLLLSAVVDLALIFWFLSILSSIVHYLLPRLQSSFSFSKKSSHDGYLRIS
QLPQLSSPIPWFGHLLGLQRDTARYVNTVIASTAAQVFTINIPFKQIIVVNPSLDKQLARHVSDTGLAQI
LAYVGSRVFGLGPATIRVILDTDPRRLHQVEFGRPENLKALSECSGVFIWDEMNKMAPSTEVDLAHWMFG
LTVSATASAVWGVKNPWRMDREFAEEFM (2)
NLTETFDSLSRPVPWLTARSAYKSRDFLMKRLREFHMQHRES
RVKTVAHAINVVAHSDPDWETNPDYYNIEMVSAIGLLATASTLSVWLVRHLLAIPELLKVVVDEIQQLQV
VQAQTQDGLKLDLTNIRTLCPWLVASWYENLRLHMTGVPRLARHEFGLTLPGSEPLAVSQGDLFLLPMCA
SNLDTNAWGPDAATFRPSRFITNNGELSNSLTRKVKAFGVAGNLCPGRVFGFETAMAMVAGTLGTFEIKS
VDGKEFTVPGVRQGFNVGFERYADDVKVVLSKR*
>CYP642A3 Fusarium oxysporum
85% to CYP642A1
FOXG_11132
MSSILQTQALSSLTINLIPTFILFSVAVYVLPALTRRLLQFLSSPSSFKEKPFTNDTPSISNLPRLSGVVPWLGHLFGLT
IDSTRYINRLIKSTTAPIFTINIPFARITVCHPSMDRVLSRHVNDTGLAQVLVYVGPRLFGLKEETIKAVFGYNPQPLHK
QKFGHAENIVSLNQRSSNNIRDRVMRMPETNEVLVGRWVFELAVSATASAVWGVANPWSMDQDFSNEFMKLSETFDTLGR
PFAWLTANSAWNSRKYLLTRLREFHLEHREARVKTTAHSINVVAHSDPNWETNPDYYHIEMVSALGLLATTSTLAVWLTR
HLLTDPELMKIILNEVQQLKHVEGEDKPRLDFANVRTACPWLMASWYETLRLHMTGVARIARHDFMLNLPDSDPIAVPQG
EIFMLPMCASNLDVDNWGPDAAVFKASRFIDKAGEVSGSAVRKVRAFGVAGNMCPGRVFGTDIVFSVVATMLRTFDIEAA
PGEGFRVPTLRGGFNVGFERYGDDVKVVLRKKGVA
>CYP642A3 Fusarium verticillioides
94% to CYP642A3 Fusarium oxysporum ortholog
FVEG_09657
MSSILPSQALSSLTINLIPTLILFSVSIYVLPAPTRHILKFLSSPSSFKEKSSINDTPSISNLPRLSGVVPWLGHLFGLT
IDSTRYINRLIKSTTAPIFTINIPFARITVCHPSMDRVLSRHVNDTGLAQVLVYVGPRLFGLKEETIKAVFGYNPQPLHK
QKFGHAENIVSLNQRSSNNIRERVMKMSETNEVLVGRWVFELAVSATASAVWGVANPWSMDQDFSNEFMKLSETFDTLGR
PIAWLTANSAWNSRKYLLARLREFHLEHREARVKTTAHSINVVAHSDPNWENNPDYYHIEMVSALGLLATTSTLAVWLTR
HLLTDPELMKVILNEVQQLKHVEGEDKPRLDLTNVRSECPWLMASWYETLRLHMTGVARIARHDFMLNLPDSDPIAVPQG
EIFMLPMCASNLDVDNWGPDAATFKASRFINKVGEVSGSAVRKVRAFGVAGNMCPGRVFGTDIVFSVVATMLRTFDIEAA
PGEEFRVPTLRGGFNVGFERYGDDVKVLLRKKGVA*
>CYP643A1 Fusarium graminearum revised
2/21/06 FG02367.1 AACM01000117 FGcontig1.117_scaffold1
MTNSTERLDSKAIRIAPNELHIDDVKMYKEIYNQTATYTKQPDFYAGFGT
PHSDVFAEHDLNLHKQR*RRLNPYFSRRAIGGLENLLKD
KVEQLGKRIDKQNGPYNLFNAVRCTTVDIISHYCTGEPLGQLENSD
ENFNGDFLDAFDAVSVSLWKFMYQPVFRSLMFGIPASIAKIVSRDARLMI
KLYGECHKSALNFKQNTPKSSHGTVFSSLSDLDEKDMGDEAVDLLIAGSD
TTAYTLAVAVVQICQNTQVKKKLVESLNAGISDVKNLPSLLGLEQIAYLN
ATVREALRFAIAAPGRLPRVVPRDSKPLVIDDQVIPAGSIIGMSAYTMNF
SKELWGKDAAEFNPDWWLGEDGKSLDTNMCSFSKGLRSCLGQNLAFAEMH
YILAYLFAKYDMELVDKSDNIKVHDRFTTYVTNHAIMVDMKKHKA*
>CYP643A2 Fusarium graminearum FG01722.1
AACM01000091 FGcontig1.91_scaffold1
MNQTYVWAIAQTETLFQSHSRNSLWGYFLVISTAGYLLYWAFDRTYKLHM
HPLASFPGPKEACVSQKWLHRVSEEGSPERVFEKLHQKY
NSRAIRIGPNE
LHIDDVTLYKSVYNQNATYLKHEGFYGGFNVPHTVFAEHVPSLHKERRRR
LNPFFSRRAIE
KLEDLLKGKIGQLGKRIDSQIGPYNIYNAARCTTVDIIS
HYCAGKPLGQLEKSDQNFHGDFLQSFDSLSKVLWKFMYQPIFRKIITSIP
DSIAKAADSETRTMLTLYDACRAAAIEYKRSPPQSDHATIFSCLSDLREE
DMGAEACDLLIAGSDTTAYTIASSIFHISQNTSIKRKLVEALDAANINVE
ELPSLVELERIEYLNATVREAIRFAIPAPGRLPRVVPHDAKPLVVDGQVI
PAGTVIGMSAYTMNFSKELWGEDAAMFNPDRWLGVNGKAMESNMCSFSKG
IRSCLGQNLANAEIHYNLAYIFGKYDVDSVTKGDKLEVFDRFATHVPSHN
IMVDLRRRENSAR*
>CYP643A3P Fusarium oxysporum
71% to CYP643A1 Fusarium graminearum
FOXG_06961
MRNIVSLGLRPPHTLTLLTASRLDSRAIRIAPNELHIDDVNIYKDVYNQNSTYIKH
ADFYAGFGTPHSVFAEHDPKLHKQRRRRLDPFFSRRTIGQLEALLKEKIEQLGKRIDSQS
GPYNIFNALRCTTVDIISHYCVGKPLGQLEKSDRRFNGDFLDAFDSVSNILWKSMYQPTF
R*IFSSIPAPLAKAISKEACLMISLYSACHTAAISFKSSPPKSANATIFTNLSDLGEKDM
EDEAVDLLIAG*DTTAYTLAAAVVQICQNTCVKKKLINTLDAGVADVDNLPSLLELEKME
YLNASVREVVRFAIASPGRLPRVVPQGGKTLVVDGRVVPAGSIIGMSAYTMNFSKGLWGD
DAATFNPDR*LGDSGKSLDANMCSFSKGIRSCLGQNLAYAEIHYILAYLFTKYNIKLVDR
EADIEVHDPFTSYVTSHAIMVDLRRREVSNSLK*
>CYP643A4 Fusarium oxysporum
67% to CYP643A2 Supercontig_9 136491-
FOXG_06968
MNSSPLPTIPQIQALIHDSQRGDILWGLVISTVVYLIYLVIDRVYKLYLHPLSKFPGPTEACLSQKWLLRVSEEGNPERV
FERLHEKY (1)
NSRAIRIAPNELHIDDVKIYKDIYNQTSTYIKQPDFYAGFGTPHSVFAEHDPNLHKQRRRRLNPYFSRRAIG
QIETLLKSKIEQLGKRIDSQNGPYNIFNAVRCTTVDIISHYCVGKPLGQLENSDENFNGDFLGAFDSVSVV
IWKFMYQPFFRWLVSVIPPALAKAVSREARLMLSLYNACQQAAISFKRNPPKSTQATIFSSLSDLGEKDMGDEAVDMLIA
GSDTTAYTLATAVVQICQNSRVKQKLVESLDAGIADVKSLPSLLELEQIVYLNASVREAVRFAIAAPGRLPRVVPRDNKP
LVVDGLVVPAGSIVGMSAYTMNFSEKLWGDDAAEFNPDRWLGEGRKSLDTNMCSFSKGLRSCLGQNLAFAEIHYILAYLF
AKYDIELVDKPDDIEVYDRFTSTVIEVSAIAGRGVIAANVSVAAGASISARCKSAIDEAQEVIEDSQCD*
>CYP643B1 Fusarium graminearum FG04724.1
AACM01000196 FGcontig1.196_scaffold3
MDYSRVVIDYFQKIINYPPSQLACLITVIIAIATFQILRAVYRLHFHPLS
KFPGPRSAAISRQWQAKIVRKGFPEKDYEKLHKEF
GTKVLRIGPNHLHIS
DPSVYKVIYSQVNAFPKEPLFYNSFESRHTVFSETDVQLHKERRKLLNPL
FSKAGVQKLEPLILEKIQETKEKIKRISKDGSINVWPALR
CMTIDIVSEF
LFGSCINMINEHPTSFESEYLKAMSLASELPFERYYSTMQRVVAKLVPLS
IAANFNPVLRQTEKLVGIIIDSYDTYKRRTTRSRFPVIFDKLESLSADLQ
KAEAINTFIAGSDTTAFTLTTALFHILHTPEVEKTLTETVDQLFGESHDI
PSLIQLEQVKYLRACVNEALRLGMGVPGTLPRIVPKQAQPFVVEGKVIPP
GTLVGMSAYTMNTDPQIWGQDAKSFNPARWLGPDSKELEKQLCTFSKGAR
QCIGMNLAYAEITMTLAHFFHYFKMELKTKELLAEDRFVHDVVGPEETKN
>CYP643B2 Fusarium verticillioides
70% to CYP643B1, not found in the F. oxysporum
genome
FVEG_12349
MASFLVITEYSPLAFLAPAAAALVTVQIVRATYMLYFHPLSKFPGPRSAAISRKWQAKIVDKGFPEKEYKRLHREF
GTRALRIGPNHLHISDTSLYKVIYSQV
NAFPKEKAFYDTFESHHTTFSETDAQLHKQRRRLLSPLFSRSGVSKLEPLILEKVKETIEKVQRISQRGPINAWPAFR
CMTIDIISEFSFGTCINLINEDPDTFSSEYLAAMEIAS
DVPFLRYYSTTQRLLAKFIPLSVAANFNPVLSQLQRLVGIIGHSYDNFTH
RTNDSRFPVLFDNLQAIPPDMQKAEAINTFIAGSDTTAFTLVTALCHILR
LPEVEKTLTKSLDEIFGEHQATPSLLQLEQTKYLRACINEALRLAMSVPGI
LPRVVPTRSQPFVVDGKVVPPG (0)
TVVGMSAYTMNT
DPQIWGQDAHSFNPDRWLGPNAKELETHLCTFSKGARQCIGIN (2)
VAYAEVTIALAHFFYHFKMELKTKELRIVDKFTTEASDP
GLLVDFKLRQHA*
>CYP643C1 Aspergillus niger
fgenesh1_pg.C_scaffold_4000279|Aspni1
44% to CYP643B1
MRQAVQLTGADMATLYKYIVEQVAEAPAAKGLSIICCTAAVATLVIVALLKPLYYRTWHPLSRFPGPPAAASSRHWIYRV
TDRGFPEEDLEKLHKKYQTQALRIGPNELHITDVSKYKVIYSQSKPFPKHEEFYEAFNTPHTVFTEIDAGMHKERRRLLN
PFFSRAG VFKLEPIIHDKVDILINKIRRLENSHNINVYDAFR
CLTTEVIMEFAFARSASMLEESETTFESWFLVAFDAVA
RSLWKMQEWPIARKALGVMPVNVIGLLDSNIVNVLKMLKFAESCLKHYEEHGNTTSHPVVFENLSSLPHDLKVTEAVDIF
IAGADTTASTLTAGFMHILSNPAIYAKLADALRGMDITSNDPSAAQLQELEKIPYLTACVKESLRIAMPVPGRLPRVVPQ
DLAEPFVVDGQVIPPGTIVSMSTYTMHTNEEVWGPDARVFNPDRWLQPGAKSLEQYLCTFSKGARMCIGQ
NVAYAEVTIVMAYLFRNFDIQLPPGFRAPEKKDLFTMEYSKPGLPLRFSSLKAK*
>CYP643C2 Aspergillus oryzae
Supercontig 6: 919868-921806 (+) strand
MSNIANMADGLGVPVLKTQGASILITLVIGIGTLHIVRSIYRRHFHPLSQFSGPPEAALSTKWLYKTNQAGFPEHEFERLHEKY
(1)
QTKALRIAPNELHLSDVHQYKVIYSQSKPFLKDPPFYSSFNIDHSLFAETDPALHKERRKMLNPLFSRAGIFKLEG
VIHTKAGIMMKKIDRLREKHLINVYDAFR ()
CLTTEVIMEFAFARSANMLEEEESTFDSWFLRAFDSVASDIWTAHEWPVLR
KIGSCLPKSIVKIMNKKVASFFEVIN ()
FAESCMNYYEKHGNTTSHPVVFDHLTSLSYPQKITEAMDILIAGADTTASTLTA
ALLHILADKKIQTKLVQALQSVQPNEQGILPLMELEKIGYL
TACVKESLRVGMPVPGRLPRIVPDNLAQPFTVDGKIIPPG (0)
AVISMSAYTMHYSEELWGSDARSFNPERWLQPDSKNLDQYLCTFSKGARMCIGQN
(2)
VAFAEITIVMAYIFQNYKLSLPSDFQRPKQKDLFTMEYGKPGLPVKFEAVN*
>CYP643C2 Aspergillus flavus
60% to CYP643C1 Aspergillus niger
99% to CYP6343C2 Aspergillus oryzae
AFL2G_02642
MSNIANMADGLGVPVLKTQGASILITLVIGIGTLHIVRSIYRRHFHPLSQFSGPPEAALSTKWLYKTNQAGFPEHEFERLHEKY
QTKALRIAPNELHLSDVHQYKVIYSQSKPFLKDPPFYSSFNIDHSLFAETDPALHKERRKMLNPLFSRAGIFKLEG
VIHTKAGIMMKKIDRLREKHLINVYDAFR (2)
CLTTEVIMEFAFARSANMLEEEESTFDSWFLRAFDSVASDIWTAHEWPVLR
RIGSCLPKSIVKIMNKKVASFFEVIN (0)
FAESCMNYYEKHGNTTSHPVVFDHLTSLSYPQKITEAMDILIAGADTTASTLTA
ALLHILADKKIQTKLVQALQSVQPNEQGILPLMELEKIGYL
(0)
TACVKESLRVGMPVPGRLPRIVPDNLAQPFTVDGKIIPP
GAVISMSAYTMHYSEELWGSDARSFNPERWLQPDSKNLDQYLCTFSKGARMCIGQN
VAFAEITIVMAYIFQNYKLSLPSDFQRPKQKDLFTMEYGKPGLPVKFEAVN*
>CYP643D1 Neosartorya fischeri
43% to CYP643C1
NFIA_045690
Note: this seq has no ortholog in A. fumigatus
MLDRFVNDVNHAEAPMWLRVLLDKSLLLIFISCVGVYAITRVLVTFYRLYLHPLAAFKGPRAAAISRNWVYKVLTGPSLP
ETVFENLHTEYGVKAIRIGPNELHLTDVSLYKTIYNQTTPYLKEHGFYDGFLTPHTIFAETDPQLHKERRKMLNHMFSKM
GVRKLEPVIQKKILTLGKKIKAIASSGPINVYDAYRCMAIDIMMRFAFGNESDAINETPGTFKATFLTAFDAASHTLADT
QENPVKRFVAGKIPLSLVAKVDKNIRVIYKLQDTAYQGIRRYKKLTESPSHPVIFDNLKSLTDKAQAAQSIEILLIGSDT
SAFTLSMGSFHILSSPECKEKLVATLNEHIPNPDAMPSLVELEKIDYLWAVVKEVLRMAISVHGRLPRVVPKEAPPLLVD
GKVIPPGTVIGMSAYTMHTSIELWVRTSAHSVLNAGYPQMELGILTGSRSICVPSARAVAYAEVTMALAYFFRTFDMTLR
TTKPELRGHFTLGFANGMMIDFKKSLRLYARNGLLLDLSLREFWGEVLSCQMMMFTTI*
>CYP643E1 Neosartorya fischeri
52% TO CYP643C1
NFIA_058010 REVISED
NOTE: THIS SEQ DOES NOT HAVE AN ORTHOLOG IN A.
FUMIGATUS
MALSGLVSAKLVIWNLT
KKQSLIILSALVAVVFIFRSLRKLYLAHLHPLAKFPGPAEAASSTAWMYGVLKSGSPENHYEKLHELY
(1)
QTKALRIAPNELHITDVHQYKVIYGTSRPFPKLPSFYNSFHTPHTVFVEIDPTLHKERRR
MLSPLFSRTGVFRLEPIIHSKVKELLHRIDQMTGKKVVNLYDAFR
HVTADIIMEFGFGRSPSIPDQKGLGAKSWLIHALE
GFGRNIWTMQERPIINRISGMIPLCIMQYFDNGFGPMARLMKYGETCLQEYEKGEYAKSHPIVFDSLPTLSYKLKVMEAV
ELLIAGSGTTASTLTSAMIHILKNKDIHARLVSALQKVQPNEEGNLALSDLERVDYLVACAKESLRFGLAVPGRLPRVVP
DGLEQPFVVDGKVVPPGTIVSISAYTMHYSEELWGADARTFNPDRWLDSRSKNLEQYLCTFSKGARMCLGHN
(2)
LASAEVIIILAYLFKYYNMSLQPEFESPKTKDNFVLEYCSPGLPVTFETCFQDGCCKGKQGAIPQ*
>CYP644A1 Fusarium graminearum FG10610.1
AACM01000444 FGcontig1.444_scaffold7
MDELKVLKIPGAVYVLAGACVLVYFIYQRAYPRPLAGIPYN
KHALKRFAGDLPEIQERQKDGASIRPWFLEQAGKHQSAIMQIFLGPFASP
AVLISDFREASDILMHREADFKRGKKVDVFKGVLPHAHPAMETWDPRFKN
TRDLVRDVMTPSFLHSVSAPKVREVSIKLAELWKLKSQFATGRPFDVAEN
IVEFSFDAILSAATGLGPSGGDVNQQVLHLAEVLKEKPLESSVDIHRPIE
VPALDRSTKLKSLVTDEETLWKGFYMPWPGLYHMVNGLRPQVKDARRVLR
NYINSQITDAIPRLQTDGKPECALDYVIQREIKAALKEGRAPVLDDPRIR
DQIYGYLIAGHDTSAGTLSWIIRRLMANPEEQVKLRSSLRETYRAAWDEK
RIPTAQELTSHAPYLDAFLEEVLRYNCPVVTIMIVARRDTIILGHAVPED
TPVFLNLTGASMSRPSVPVDESLRSKSSKSYKPARENWDDMDPEMFYPER
WLVEDQDGKKSFSASAGPTLAFSAGNRGCWGKRLGYLELRVVLSILIWVF
NFEEVPEEIVNWDTYDSLVTAPKECFVRLTEAYPGAI*
>CYP645A1 Fusarium graminearum FG00127.1
AACM01000005 FGcontig1.5_scaffold1
the second part after the heme signature resmbles
a
phthalate 4,5-dioxygenase reductase subunit
MFNKKTATTSKPDMITKCPFSNPNSLFQDLATVRQTDGIEYNEKLKGYLV
TRFDDIVDVLNRPDEFSSRPTVPDFPPPVKPLFKDKVPEKGTLLAWDNPD
HDRLRKSVASFFVPRRLKRFEPMLHDAANELIDSFIDKGTADMKSAFALP
LPLRSIVTIAGLDPERWQWIGQCLTLFGGIARRDDEEEVSIQQKIQDVLD
LHEYIRQVIEERRLDRRDDLISHIWNERDAGTVIMTDFEHLSMIPGLLLA
GHETTTNVLTMGLAHILHNGLWEQISQSDETRKAAIEELLRFESAITGMP
RQVTSDGVQLCGMKLNAGDRLFVAYNSGSRDESKFENPNKLDISRQSKTQ
HLGFGRGVHACLGAPFARLLLRTELAVLYTRLPNLRLVTPYEELAYGEVH
EARSIGATFYAWDIPSPGTARKVHVQSNGNATSRSAAVQNIPMVVQSLGS
VAQNIMQISLQPKDTAKQIEWTPGAHIDINVGTFGYRQYSVCSDPTDTQQ
LKIAVLREDQGTGGSRYLHENLKVGDKISIRGPRNNFKFTPGTRRTFLIA
GGIGITPMIPMAEEAAASGIDYKIIYLGRSRAGMAYIDKITQRHGERAMI
WVTDEHDGARLELAKLLQAEDPNGLRVYCCGPESLLTAVGESMSHAPLGT
VHVERFANPVSPLSSSNTAFDVLMAKSGRVLHVPEDKTVLEVINEAGGNV
LSTCNKGLCGTCEVGVLEGTPEHRDVVLTAAERAENSSMMTCVSRCRGKS
LVLDLW*
>CYP645A2 Fusarium oxysporum
60% to CYP645A1, this seq. has a C-term
extension
FOXG_02323
the second part after the heme signature
resmbles a
phthalate 4,5-dioxygenase reductase subunit
MTCPFSNPRNLFDDLATARETPSIEYSEKLGGYVISRYDDIVSVLDNPAAFSSRPTVPDFPPQVKQIFANKVPERGTLLA
YDNPDHDRLRKSVASFFVPRRLERFEPLLRATAHGLIDGFVEKGCVDIKSNFALTLPLRTIVIVAGLEPSRWQWIGRCLA
LFGGITQTNEELSIEQRVQDVLDLHEYVAEVIAERKTDRRDDLISHIWNERDAGVVEMTDYEHLSMIPGLLLAGHETTTN
LLSMGISHLLHHDLWNAATEDEEARSTAIEELLRYESAITGMERLVKEESKIGDHIVQPGQKLFVAYNSGSRDSTKFGNP
DKLDFKRQHKHQHLGFGRGIHACLGAPFARLLLRTELAVLKERLPNMRLETPYEEIQYCRVHSGRGPERVEIAWDVPSLD
EMRVNVGQATVNSALRSSAKTEDLEMVVENVENVTERIVTLTLRPKDGGKVPKWSPGSHVDVQAGTIGYRQYSISSKPSD
DQHIKIAVLRENDTGASNWIHQNAIKGSQMLIRGPRNHFSLEFGSRKTIFVAGGIGITPIIPMAEAAKQADVDYTILYLG
RSKNNLAFVNELTEEHGDHFKLWYWPEATRFCEYRKTNRFWR*
>CYP645A2P Fusarium verticillioides
85% to CYP645A2 Fusarium oxysporum
no gene model, no introns
the second part after the heme signature
resmbles a
phthalate 4,5-dioxygenase reductase subunit
MTCPFSNPRNLFKDLAIARETQSIEYSEKLGGYAISRYDDIVS
VLDNPSVFSSRPTVPDFPPQVKQIFANKVPERGTLLAYDNPDHDRLRKSVASFFVPRRLE
RFEPLLRATAHDPIDGFVEKGCADIKSNFALPLPLWTIVIVAGLDPSRWQWIGRCLSLFG
GITEMNEELSIEQRV*DVLDLHEYVAQVIQERKKDRRDDLISHIWNERDAGVVEMTDYEH
LSMIPGLLLAGHETTTNLLSMGISHILHHDL*DAATKDEKLRNTTIEELLRYEPAITGME
RLVKEESKIGDHTAQPGEKLFVAYNSGSRDTTKFENTDKPNFNRQHKYQNLGFGRGIHSC
LGAPFA*LLLRTELAVLKERLPNLRPTTPYEEIQYCKVHAGRGPERVEIRWDVSSLDEMR
ANVGQANANSTLRASAKTEELEMVVKNV*KVTERIIRLMLYPKDGEKVPKWSPGSHIDIQ
AGTIGYRQYSICSKHSEAQHLKIAVLRENDTGASNWIHKNTVKGSQVLIRGPRNHFSLEF
GSGKTIFIAGGIGITPIIPMAEAAKEAGVEYSILYLGRSKNNLPVI*
>CYP646A1 revised Aspergillus nidulans
AN2596.2 AACD01000043
this gene may have a frameshift & rather
than an intron as shown below
based on comparison to other sequences
This may be a pseudogene
MLLELDVSLFSMAALVGTLVCIVVKLFETSPVPKDIPWV
LKKQNVLRRAAERFIGVNPISFIQEGYEK (0)
YSKNQQPFVMPSVNEGDEVVLPREHSNLVLFAKES
EYSFKAHISDFFQLKYTSWPLAFAEKYDFFVKLVSKDLTETLKSDAIAEA
LANEARACLSDIWGEDEDNWVEVPLYSAME
KSAA
261319 & 261317 RLINVLAIGPGNS
HDTSLLNAMTNCSNAIVFGANVIKAFPSFLHG (2)
IVGPIVGLVNRWQERVFHTRMKPLIEARIKTQREAVDKAALQENLKAQGSLLDMLINAGLRSKW
PVEVETMWLAYRIFMINFPGVHTSGISATSALLDILSFPSEEGLIDMLQAEIQNIAAS
SCGKWTAAELEQASLLDSAIKESLRFNGINALSPTRM (0)
VVAPEGTTLPNGLFLPYGTKI
GIPQYAVHRDSDLYPNPDQYNPYRFYTPGASPAQLRESSMTNTSESYVVFGHGRRQCP
GRWIFAHIFKLLIAEMLLKYEIKPFPTRPKIH (1)
RWGRFQLPPLTTKLTVRRRKDTA*
>CYP646A2 Aspergillus fumigatus revised 7/18/07
AAHF01000014
80% to 646A1
join(572205..572288,572338..572670,572727..573086)
locus_tag="Afu8g00960" second P450 of 8 on this
accession
80% to 646A1 Aspergillus nidulans
MLLNISAFALSTTGVLCMLLCLVVKLFETSPVPKNIPWVLSKKGFFGRAAERFLGVNPIGFIQEGYQQ
(0)
YSKNQQPFVMPSVNEGDEVILPKEHSNAVLFAKESEYSFKAHISDFFQLKYTSWPLAFAERYDFFVKL
VSKDLTETLKSKAVAESLAEEARSCLSEFWGEDTDNWVEVPLYSFME
KVAARMVNVMAIGPGSS
HDTTLLGAMTNCSNAIVFGANVIKAFPSFVHP (2)
IIGPIVGLVNRWQERVFHARMKPIIEAKIKEQKEADDPQSLQERLKANGSLLDLLIQAGLRSKW
PVERETMWLAYRIFMLNFPGVHTSGISATSALLDILSYPTEEGLMDMLQAEIEQIAAN
SDGSWSAADLERASLLESAIKESLRFNGINALSPTRK (0)
VVAPEGAFLPNGVFLPYGTKI
GIPQYAVHRDSDLYPNPNEYNPYRFYKENATPEERRQNLMTNTSDTYLVFGHGRRQCP
GRWLFAHIFKLLIAEMLLKYEIKPFAARPKIH (1)
RWGRFQLPPLSVKITVRRKKNPVAVCNQFST*
>CYP646A2 Neosartorya fischeri NRRL 181
92% to CYP646A2 = ortholog
XM_001261718
NFIA_094420
MLLDINASTLSATGVLCMLLCLIVKLFETSPVPKNIPWVLSKKG
FFGRAAERFLGVNPIGFIQQGYEQYSKNQEPFVMPSVNEGDEVILPKEHTNAVLFAKE
SEYSFKAHISDFFQLKYTSWPLAFAERYEFFVKLVSKDLTDTLKSKAVAESLAEEARS
CLSDIWGEDTDNWVEVPLYSFMEKAAARMVNVLAIGPGRSHDTSLLNAMTNCSNAIVF
GANVIKAFPSFLHPIIGPIVGLANRWQERVFHARMKPIIEAKIKEQKEAYNSHSLQER
LRTNGSLLDLLIQAGLRSKWPVERETMWLAYRIFMINFPGVHTSGISATSALLDILSY
PTEEGFMDMLQAEIEQIAANSDGSWSAADLERASLLESAIKESLRFNGVNAVSPTRKV
VAPEGAILPNGVYLPYGTKIGIPQYAVHRDSDLYPNPDEYNPYRFYKENATPEERRQN
LMTNTSDTYLVFGHGRRQCPGRWLFAHIFKLLIAEMFLKYEIKPFATRPKIHRAGWGR
FQLPPLSVKLTVRRKKNTVAVYN*
>CYP646A3 Aspergillus niger
fgenesh1_pg.C_scaffold_3000278|Aspni1
66% to CYP646A2
MFLSISIASWLVIGIIGVGLCLVVKLFETSSVPNGIPRVLNREDLVGRAVERFVGVNPIGFIREGYQKYSKHQKPFVLPS
VAEGDEVLLPKDLAKHVLFSKENEYSFKAYITDFFQLKYTSWPLAFAKKYDFYVKLISKDLTETLKTDSVARSLAEEARS
CLADLWGEDSETWVDISLYCAMEKMASRMINVLAIGPGHSDETLLNAMAHCSDAIVFGASIIKAFPSFLHPIIGPIVGMI
NRYFEVIFHKRMKPIIESKIKEQQKQRDPEAQEETLKSVDSLLDLLIRAGLRSKWPIEATSMWLSYRIFMINFPGVHTTA
VSATSVLLDILSDPIDENLVNHLRAEIESIAGNSSGYWNAEDLERAALLDSAVKESLRLNGINAASPTRKVVAPNGVSLA
NGLFLPCGTKVGIPQYALHRDEEIYPEADRYNPYRFYIENASESAIRQSSMTTTSDEYVVFGHGRRQCPGRFIFAHIVKV
FIAEMLLNYDVQPILVRPKIHRWGRFQLPPLTTKLTVRRKKRN*
>CYP646A4 Aspergillus clavatus
82% to CYP646A2, 79% to CYP646A1
ACLA_044680
MTAAMLFNLNVSTLSATALVCMLVCLIVKLFETSPVPKNIPWVLSRKGFLQRAAERFIGVNPIGFIQEGYEKYSKNKQPF
VMPSVNEGDEVILPKEFSNTVLFAKESEYSFKAHIVDFFQLKYTSWPLAFAEKYDFFVKLVSKDLTETLKSKCVATSLAD
EARSCLTDIWGEDTENWVEVPLYSTMEKAAARMINVLAIGPGESHDTGLLNAMTNCSNAIVFGANVIKAFPSFLHPIVGP
VVGLVNRYQEHAFHTRMKPIIDAKIKEQKEAYDSEKLKEHLKTKGSLLDLLIQAGLRSKWPVELDTMWLAYRMFMINFPG
VHTSGISASSALLDILSYPNDEGFGDMLQDEINKIAAGSDGSWTAAELEQATLLESAIKESLRFNGINLLSPTRKVVAPE
GATLPDGTFLPYGTKIGIPQYAIHRDSDLYPNPNEYNPYRFYKEHATADELRQNSMTNTSDTYLVFGHGRRQCPGRWVFA
HIFKLLIAEIFLKYEIKPLATRPKIHRWGRFQLPPLTVKLTIRRKKDTVAVFK*
>CYP647A1 Aspergillus nidulans AN8250.1 37%
to 623B1 54 clan
MSTAWTNSWIAIAVTTFLVAVFVLLYSAPQSEIDIPLVRDRGRKRFRTST
FVSYLFNANDILQEAYDTYLKHGKTCRVPDKSLGTMILIPNRYMKWMLSQ
PTGVLNSYEAIAEIVQARWTLGDTRYLSDDWHLNMLRDALRPLSKSGIVE
FQEELERSMEDVLGNDHVNWKDVNPTIATKRIILQATTRYLVGSPLCADE
QFLRWILIFIEWITPVGELLRLTPRGLRSVVGHIFSIPRFIVIQKLKAIL
RPQYDKRLSFIRSGQSPEDGPQDLLQMMMRDLYERNSTDLNLHFITINVL
VFVIAAVVQTYMLAPSVLYDILESNAEYNTISKLQEELVCVLGEPAQGQR
WSQNEARQMAKLDSVLRESLRTNTLVSQTMPRKVMVDSLQTPDGITLPRG
ATVALLARAAQTDPDIYPNPNKFIPFRHAVPGGKQFAATGENFLAFGHAK
HACPGRFLVSVELKMLVAHILRHYHIELPAEYGGKRPKAVWFTDLNLPPQ
HGVIRVKRCV*
>CYP648A1 Aspergillus nidulans AN3256.1
poor match 54 clan
MFQAASSVLSTLYQICANGAQAPLPAGSVWAILVLLLVALILLVCRYADS
YDGVPVVNRICALEPRVFSRIRFAFNAEQILQDAYRKYDGKPYIIARGDA
DYLVLPSESVTELNRLPASIINSRMCHAYSMTGHLNGMNVVLKSNLHVKT
LLNRITPALPAFLGPASARMQATMQETFPSVSSWTTIEPLDLVVGCVSRA
ITLAAVGEPWCDDTELVNLTFEHTKLVFTVMFAMRLVPAALQPVLVWMLP
HKWRLQKSLQRLESFIVPIVQECKAAKPRPATERPSTLLAWMVAEATNDV
EEDPYVLTELLAALAAGGTYSSANFIVSVILDLIANPQFLDEIREEIRQK
HEELQGRWDFAAFNNLPKLDSAFKETIRLTPGSLTTYSRVMLQDYTLSTG
ITLKKGQFICVSSYARAKDDEIYQNAGSYDALRAYNESQQYHAAQPFKGV
YQQEFRWGAGRWACAGRHLASLLAKFIVVKLLDEYEFQFVPGSHRPPNSV
FHEFVFVHPSTRLLTRRREENLGICCW*
>CYP649A1 Aspergillus nidulans AN3253.1 32%
to 503A1 54 clan
MEDPSSLPSLYPGLFVLFLLYFAGDLIATRRAAQRQKDHPLVGSPSWWTP
RFGLNLVFAARAVEILQTGYHKFKNRTFQLIRGDGSVVILPLHLIDELSS
LPQSVASSHGALERDLLGRYTGLDIILTSRMHHTIVQRKLTPRLAALTPS
LQDEVSLAVQEGFPHSTEWTIVKPYQILAQVAAKIAARAMVGPSFCRDPR
WLDISVNYTESLFRTIVILRLFPGWTHPVLSRCLPSYWAGKRYLQRAKGI
LGPKIDELIRRNDTGEWSPERTESDFNVLCWLVEAAKGRDRNAETLAHIE
VLLALAAVHTILLRLVNVLYDLVAHPALFEELKEEIQDIGFNEDWNFGSY
NKLRKLDSVLRESQRLSPPTILGLKRLFLQPYKFTSGITVPAGTYVALPV
MAIENDPLHTDNPEEFDGLRSYRRIEQKTASMRPNPKDGPQFSTIEKTVL
GFGYGKSACPGRYFASLVLKMVFVKLLTEYDFQFLPGRSRPKNYLVHEFL
FPWPWDKILVRRRENGVCPF*
>CYP650A1 Aspergillus nidulans AN9251.1 40%
to 54 clan
revised 7/19/07
MIIFNISALGPPKPMLQFVGRELVETSRATMLRLPIDSAMHPFSTLPNHE
LGLYIMWMMSAVFVIFKLLAPAKCDIPTVNGRRRFEIGQYQARRRFSVDG
RGIILNGLQMARVFRVVSQKGPKIILGPEYANEVKSHPACNADVFIAKEF
HAHVSGFEVLRPQQVMKDAIRLRLTRSIGALMKPISAETALILESQWGNS
NCWHELDLNFTIA
SLVSRVSAVMFVGEELGRDQKWLSIVTNYSSDMFVADLDLCKWPEALR
PIATYFLPSCGKLRRHIREAALMLYPILSEGYSAHQNKQNFLDWLEEIAG
DRKYNPVLAQLSLAAAAIDTTSDLIIKTLTDICRFRDSQKLQEDLREEMV
RVLRADGWEKSAMYNLKLLDSVLKETQRVKPVVVFGMGRYVTEQITLHDG
TVISKGETINVVNTRIWDPAVYPNPLEWDPYRF
VRRRDSGDHAAHLVSPTPDHMGFGLGKHSCPGRFFAATKIKIILCHILLK
YDVKIPDEEISTVISSG
NFLFPDSTLRISVRRRQDNLTIWD*
>CYP650B1 Aspergillus nidulans AN9248.1 40%
to 68a1 54 clan
MAMGNPELRTHFFRSSHEPGIPNSLRFPNGFLVTCGLPWLLLLFSVTIIL
FHPLRKKSDLPLINPGKGRIGILRGYRSRKTFTTELPRLVADGLSKASAF
RIAAPDGVNIVLAPSYAHEIAEHPDLNPGPIAGDEFNSHINGFEVFAQLG
TSDVISESVRTRLTRQLTKLTPLLTSETPLLLQSQWKDAPDWVEVSPHET
ALFILSRLSSLVFVGDDLGRNPDWIRILTSYNTEAFAAAEELNLWPQILR
PLIARLKPSCRQLRRYIRDARALLVPVLEQRRHAQSQGDRREYNDAIEWL
DETSRSTGQPYDPILSQMLLAIGSFHTSSDLLGQVLLDLCMRPDWKVLVR
ELRKEIISSLQGEGWDKIALNNLKLMDSVLKESQRLKPASTVTMGRYASR
EITLSDGTIIPKGSTVFIANVAMRDSNIYPDPDDFVPDRF
TTRREKGDSSAYLVSASPEHLGFGLGRHACPGRFFAANELKIVLSHMLMK
YDIKLPDNGA
VAPSKSGIFLATNPDARICVRRRKEEIVI*
>CYP651A1 Aspergillus nidulans AN9253.1 34%
to 68D1 54 clan
revised 7/19/07
MLQETISLTPLGQPLIAGFVVVSAVLYLLYNTQQWRPNNLPLLNDGGPFD
FLQVTAVNRFRRDARRLIKSGFDS
MRTDVGVELFASPEYADQFRNHPSLKVFPFTAKMHHGHLPGFELCRSQPV
EDRILIESVRTQLAQSLGKLIQPLASDIGEAISDRWPSESGWQEIVLGSV
VERTIAQGTSSVYCLDEAWPEFVVKMEMALGMASAALSAWPVMLRRIVAK
FLPECLELYRIMKSGRELMSRDMRRRTALQASTGEEPLNFFEWFKEASHG
EEYDELILNLRIAFASMHGLCDHLVKILLRLSEDPQLVSDLRKEVIQVYE
THGWSKTALYHLKLMDSAFKEVQRVDPILFVGRVAVADVTLKDGLIIQKG
QSIRISGHTMWDEDKYPDAAHFDPYRFYRLRQAPGQENTAQFTSPTSDHL
GFGYGGRACPGRFFAAAVLKISLCHVLMKYDIKPANGETGQHVWEFAAAI
NANMTAKVLVRRRQPEIQI*
>CYP652A1 Aspergillus nidulans AN8139.1 37%
to 68D1 54 clan
MLQSLLQNNFVAVLGLLIVFGTATSLTWTAFTILSPYLRVKGAKIFNDRT
GSEILWTNARKRFQRGARELFKAAFAQHPNAFYIMTDTDVELILDSKYAP
EVRNDRRFDIGKYNEDMFHGTIAGFEMFENDHVLERVFVETVRNKLTRAI
GKFVKPISLEAADGLREYWTDDTGIPAPTRNHSCVLRTIAKQSSRVFQGP
PLCYNPDWLRITVNHTVTFFEAAESLKVWPHPLRPLAAKFLPLCKKLRAE
AQEARRIITPILEERLKRAQARMAEKNNLPEKKTEVKEEGDSDGNMIEWA
EETANGAIYDAALLQMKVSLASIHTTSDLVSQTLFNLCSRPELVNDLRKE
VIEVIGQQGWVKPALYQLKLMDSVLKETQRLKPISIGTMVRTTTSPVTFS
DGLQVPANTRTLVSCHNMWTESVHENPEVFDGYRFLKLRQLPGQENWTQL
VSTSNNHLGFGHGMHACPGRFFAATTAKVLIAHVVLKYDLKLLDGQKPVI
IEHGAAQYANVWCPIGVRRRREEIDLSDL*
>CYP653A1 Aspergillus nidulans AN8184.1 33%
to 503A1 54 clan
MSPMVLCTSLLVLLAWLLSKSPTDTTPVNVPTVTLGRFVPCFVDRLLFCA
KGPFLIYDGYKKSVCGDYTNILSDSFLPAQTVVKKLTPALGRIVPDVIDE
LKHAFDVEVPECYDKWVTVTIYSMILKLINRSTSRIIVGDSLCRSEDWLN
TVLDYTYNLGTIIFLLRPLPRFLRPLVAGLLPQVRHARKILDHVKNDIIV
PMILERRQKEANDSNYRKPDDFMQWMMDTADNDYDKQPGNIAQGLMIIMA
LAVIHTSTITITQSLYDLLIRPEYVQPLRQEIIDTLKHGWANATRADFAT
QVRLDSFLRESQRLNPTHEVNVQRIAKETLVFKDGFVVPKGTHICFAAGP
LSRDPELIDDPETFDGFRWCKDRQYNKKGHNNSLVALSKLNLHFGYGRQA
CPGRFFAENTSKAILSRLLVEYDLKFPEGKEGRRPWNIRNGEQIVPNVYT
KVLIRKRLVNL*
>CYP653A2 Aspergillus fumigatus Af293
GenEMBL
XP_748033.1 also EAL85995.1
47% to 653A1
with errors, 56% to last 366 aa
needs
revision, removed intron GKYLLCVHLLECLTADESQLQ
MHLASFSLLTSITLHHYCAHNTPITLHNIDQLLNGTSLAQRRILRLSSAKLSVMADQVLELPCWPFALLL
SSSLYFFHYPPGETSAEIPTVRFSRFLPGFINRLMFIFVAPYLIKYGYEKYRDQPYRILKADGDLLVLPP
KYLPEIRHLPPSKLSGVDAQFENILGKYTNVLIDSNLPVKTVHKGLTPAI
GRVLPRLLDELQFAFQVEVPDCDDRWVPVNLYDMILGLVTRATSRVIVGKNICRNSQWLETVTSYTVNL
GVTVILLRPFPNFMRPLVAKVLPSVKKLRTQLRFVQNELFIPMILARREAEINGPAYQKPDDFLQWMMDL
AEDDFDKDPANISQMLLIVMALAVVHTSSMLMTHAIYDLMIRPEYIEPLREEIRGTLKDGWDKVTQASFA
SQRRLDSFMRESQRFNPTGELSTHRMVMETMVLSDGLVLEKGTHICFPSKPMGMDDSIIEDALTFRGFRW
CEDPEARSTSLVSISPSNMHFGYGRQACPGRFFAANTNKAILGRLIADYEFKFEGDNNKRPRNLTLGEQI
MPNMHTKILLKKRAFV
>CY653A2 Neosartorya fischeri
95% to CYP653A2 Aspergillus fumigatus = ortholog
NFIA_039010
MADQVLELPCWPFALLLSSSLYFYHYPPGEASAEIPTVRFSRFLPDFINRLMFIFVAPYLIKYGYEKYRDQPYRVLKADG
DLLVLPPKYLPEIRHLPPSKLSGVDAQF ENILGKYTNVLIDSHLPVKTVHKGLTPA
IGRVLPRLLDELQFAFQVEVPDCD
DRWVPVNLYDMILGLVTRATSRVIVGENICRNPQWLETVTSYTVNLGVTVILLRPFPYFMRPLVAKVLPSVKKLRTQLRF
VQKELFIPMILARREAEMKDPAYQKPDDFLQWMMDLAEDDFDKDPANISQMLLIVMALAVVHTSSMLMTHAIYDLVIRPE
YIEPLREEIRETLTDGWDKVTQASFASQRRLDSFMRESQRFNPTGELSTHRMVMEKMVLSDGLVLEKGTHICFPSKPMGM
DDSIIEDALSFRGFRWCEDPEARSTSLVSISPSNMHFGYGRQACPGRFFAANTNKAVLGRLIADYEFKFEDDNNNKRPRN
LTLGEQIMPNMHTKILLKKRDLV*
>CYP653A3 Aspergillus clavatus
76% to CYP653A2
ACLA_002050
MIPLWPIILLFCSSVYFYFNPPGEKSNDIPTIRYSHFLPDFVNRLIFIVAAPQLIKRGYDKCKNGPYRIIKADGDLVILP
AKYLAEIRHIPPSRLSGVDAQFENILGKYTNVLVESHLPTKTVIKRLTPGI
GRVLPRILNELQYAFHVEVPDCDDKWVSV
NLYDMILNILTRATSRVIVGETVCRNPKWLQTVTNYTVNLGITVMLLRPFPEFLRPMIAKVLPSVKKLRTQLRYVQKELF
IPMILSRRYSEKNEPAYEKPDDFLQWMMDLAEDDFDKDPANLSQNLLIVMSLAVVHTSTMLMTHTLFDLIIRPEYAQSLR
EEIAATLPDGWDNATQAAFASQRRLDSFMRESQRFNPTGE LSTHRMVKEDMVLSDGLVLKKGTHICFPSKPMGMDSSIVK
DALTFDGFRWCDDPENKNASLVSIGPSNMHFGYGRQACPGRFFATNTNKAILSRLIADYEFKFEDGRKTRPNNILLGEQI
MPNMYTKVLMRKREFV
>CYP653B1 Aspergillus oryzae
GenEMBL
BAE61541.1
46% to 653A1, 51% to 653A2,
MDYMDYLKEMGLAWHWVPIFVGLLAFYFIMERSTANASRTSLPIVKHFKLLPPFFNRILYVVKAPFLIYY
GYEKYKSKPFRILKLDGDLVVLPQKYLEEVGGLHSRQASLVGAKYK
NILGGCTNILINSELPARTVSEKL
NPVL DRQIPRLLFELHHAFSAVVPYCEGRYVPINLYHMILKLVTHSTSRIIIGQRLCRSEQWINTITKCT
YDVRIAVKQLQLVPRFLRRLVAPFLPSVQRLETQLRWIAEQLILPMIQHRRRRELNDPSYKKQEDFLQWM
MDLADNDLDRDPMNLAYGLMITMALAVVQTSTMLITHAMYDLMVHPEYLEPLREEIHETLTNGWIRASLS
DFGAQRRLDSFLHESQRLNPPSEVSAQRVLGRPLTLSDGVTLPKGTHVCFPSGPMSRDPTVVPDPLTFDG
FRWCKDLNAPDGSLTDVSPANLHFGFGGQACHGRFFGAVIAKAVMSRLLAEYDLKFEEGQSGRPENIVNG
EQIMPSISTKVLIKKKNVDI
>CYP653B1 Aspergillus flavus
99% to CYP653B1 Aspergillus oryzae
AFL2G_09894 revised
MDYMDYLKEMGLARHWVPIFVGLLAFYFIMERSTANASRTSLPIVKHFKLLPPFFNRILYVVKAPFLIYYGYEKYKSKPF
RILKLDGDLVVLPQKYLEEVGGLHSRQASLVGAKYK (0)
NILGGCTNILINSELPARTVSEKLNPVL (1)
DRQIPRLL
FELHHAFSAVVPYCEGRYVPINLYHMILKLVTHSTSRIIIGQRLCRSEQWINTITKCTYDVRIAVKQLQLVPRFLRRLAA
PFLPSVQRLETQLRWIAEQLILPMIQHRRRRELNDPSYKKQEDFLQWMMDLADNDLDRDPMNLAYGLMITMALAVVQTST
MLITHAMYDLMVHPEYLEPLREEIHETLTNGWIRASLSDFGAQRRLDSFLHESQRLNPPSEVSAQRVLGRPLTLSDGVTL
PKGTHVCFPSGPMSRDPTVVPDPLTFDGFRWCKDLNAPDGSLTDVSPANLHFGFGGQACHGRFFGAVIAKAVMSRLLAEY
DLKFEEGQSGRPENIVNGEQIMPSISTKVLIKKKNVDI*
>CYP653C1 Aspergillus oryzae
GenEMBL
BAE65194.1, AP007171.1
40% to 653A1
45% to 653A2, 41% to 653B1
63% to
CYP653C2 from an indole-diterpene gene cluster
note the
other P450 in this cluster is CYP698A1
The ortholog
of 698A1/paxQ (698A2) is 4 genes upstream of this gene
14 P450
genes and 2 pseudogenes on this contig
1897240
MDKLTATLAKVNYPSEVENGSMLLVVTLVILFLWFIIPSPVKRSNVSVPTVTLFNPYLPEFLSRVWFNST
AATVIYKGYRQHKDRAFRLLKPDGDIIVLSNKYVEELRQLPLTTLNALEAVFE
DHVGKYTTILNDSHLHT
EVIQKRLTPAISRFIPRIIDELDHGFAVEMPECEDKWALIRPYEVFLRLVARAGARVFVGPEICRTEKWL
TASIDFTKNIFMTITLLRPIPSFLHPIIGPMLPSSRSLDTQLRYVQDELLGPEIVKRRQRQASGDPDYEK
PDDFLQWMIDLAQNDKEGDPGNIAHRLLGLTSMAVVHTSAMSITHGLYDLITMSQWLEPLRQEIQEAMPD
WKSSSYSSLVSLRRLDSFLKESQRFNPPGELSFHRVVKKDLVFSDGLRLPKGTHICMASGPIGMDTKYVS
DPTTFDAFRYVDGDKAQSQFVHTSATSMHFGLGRYACPGRFFATFVLKAILSRFLVEYEFRFGPDQVGRP
KNMLLGDKIVPNTSVDVYVRKRTGSRSTA 1899076
>CYP653C1 Aspergillus flavus
98% to CYP653C1 Aspergillus oryzae
AFL2G_05469 revised
MDKLTATLAKINYPSEVENGSMLLVVTLVILFLWFIIPSPVKRSNVSVPTVTLFNPYLPEFLSRVWFNST
AATVIYKGYRQHKDRAFRLLKPDGDIIVLSNKYVEELRQLPLTTLNALEAVFE
DHVGKYTTILNDSHLHTEVIQKRLTPAISRLIPRI
IDELDHGFAVEMPECEDKWALIRPYEVFLRLVARAGARVFVGPEICRTEKWLTASIDFTKNIFMTITLLRPIPSFLHPII
GPMLPSSRSLDTQLRYVQDELLGPEVVKRRQRQASADPDYEKPDDFLQWMIDLAQNDKEGDPGNIAHRLLGLTSMAVVHT
SAMSITHGLYDLITMPQWLEPLRQEIQEVMPDWKSSSYSSLVSLRRLDSFLKESQRFNPPGELSFHRVVKKDLVLSDGLR
LPKGTHICMASGPIGMDTKYVSDPTTFDAFRYVDGDKAQSQFVHTSATSMHFGLGRYACPGRFFATFVLKAILSRFLVEY
EFRFGPDQVGRPKNMLLGDKIVPNTSVDVYVRKRTGSRSTA*
>CYP653C2 Penicillium paxilli
GenEMBL
AF279808
paxP gene
part of an
indole-diterpene gene cluster, also includes CYP698A1
MDLSDFHISTPLRYFHEEASLLWKLGVFAVLVYFLLPKPTYKTN
VKVPTVKYMGPWMPEILSRIFFNSHAPTVIYKGYEKFKTSAFKVVKPDGDLVVLSTRY
AEELRQMPSTTLNALEATFTDHVGGYTTILTDSHLHTETIQKKLTPAIGRLIPRMISE
LDHAFEVEFPTCDDQFASINPYTVFLRLVARVGARIFIGDELCREEKWLQASIDYTKN
IFLTIALMRPMPGFLHPIVGRILPSSRSLKDQLSYIQQDLLGPVIKERRRLEASSDSE
YKKPDDFLQWMMDLAQNENESHPDNLSHRLLGITSMAVVHTSAMSMTHILYDLLTMPD
LIEPLRDEIRNEIKDWNKATQADLSRLIIMDSFLKESQRLNPPGDLSFHRVVKKDLTL
SDGLFLPKGTHICMAAGPISKDPDVVSDPDTFDAFRFVKQRTATSGFVSTGPNNMHFG
LGRYACPGRFFAAFVIKLILSRFLMDYDFKFETEHKERPKNLLIGDKIVPNVATPILI
KRRATKA
>CYP653D1 Aspergillus terreus
50% to CYP653A3 Aspergillus clavatus
ATEG_09291.1
MGAGSLYILLPVLLGYILVFYHALSISRKTKNNIPILKHSRFLPDWINRRIFFLNAPAQIQYGYDKYNNMPFLVLRPDHD
LLVLPARYLAEIRQIPSSRLNLIEAEYN (0)
NILGDYTNILKDSE
(small seq gap, 14 aa)
GRILPRTMQELQHAFDVEVPPCSDGWVSINLYTVILRLVARVASSVVFSDE
TCRNETWINTMISYSDNLGPTIVFLRPTPDFLRPLVSRLIPSVNRLKQQLRWVQEELIVPAVTARRAAQAANPDGPKPDD
FLQWMMDVAANDIDRDPRNIAQSLLIVTAVGMMHTSTMLITHALYDILSHPECFDPLRQEIKDTLPQGWINATVAAFAAQ
EKLDSVLRESLRLNPPAE (1)
VSTQRIAKEKFTFSDGFAIPDDVQICFPSGPVARDPAFLPDAHVYDAFRWCRDPEASNK
KLVSISTTNFHFGYGRLACPGRFFSANTMKAVLSRFIAEYDMRFESEHQARPANLRFGEQ
IMPSMWTKVLIRKREVKV*
>CYP654A1 Aspergillus nidulans AN3274.1
second half = P450 35% to 512A1 54 clan
revised 7/18/07
MILKLIPVTGGAALLLQASALLSFAWLLLAWASRRRRNRLIPGVYVAGLKSGKVPLSQARQAFIHGCA
DLMLEGYQKTQGGLFYVPSPAGERLMIPTKYLDELKN
AANEEVDFTASFSEMFEGRYTTIGQKWHLHPDVVKKSLNANLELIMPDVY
DEIVHAYRSLLTPSHDWQPVRMSEIFTQIISRASNRMLGGKALSRNRDWT
DTSINFTTDTWLASQQLKRYPAWLRPVIQHLLPEMGRVRRHFTVARQVIC
PIVQKRSESDNDTKKPLDLLQMLWEGAEPVDQTPEFMAYTALAISFAAIR
TSSSVPTHLLYDLCARPEYIAPLREEIESVLREEGSIFTKAALNKLLKLD
SFMKESQRFNPLSLLTFGRVIQSDRILHDGLVIPKGTIIGVPAHAISQDG
DFYPSPSTFSPFRFVPSAPGEKTAGFVTTNASSSLSWGYGKHACSGRFFA
ANEIKLIMAYFLLNYDFQFAGGRTERPANYTFELQNMPDETVEVLVRRRK
DGNL*
>CYP654A2 Aspergillus clavatus
XM_01273842
note stop codon in genomic seq AAKD03000032.1
ACLA_063880
1
MILELSPVTGGAALLLQASALLSLALLLLSRVSGRGRNRLIPGVYVTGLNGGKVPLSQAR 180
181 QNFIHGCADLMLEGYQKTKGGLFYVPSPAGERLMIPTKYLDELKNAANEEVDFTASFSEM 360
361
FEGKYTTIGQKWHLHPNVVKQSLNTSLGMVIPAAAAAESSDYFYATSHNRANRADYARYW 540
541
QPVRMADIFTQIISRASNRMLGGKALSRNRNWTDTSINFTTDTWLASQQLKRYPAWLRPI 720
721
LQHVLPEMSRVRRHFTVARQFICPIVQERSESEKGTIKPLDLLQMLWDGAGPADQTPEFM 900
901 AYTALAISFAAIRTSSSVPTHLLYDLCAQPEYIAPLREEIESVLCEEGSLLTKTALSKLV 1080
1081
KLDSLMKESQRFNPLSLLTFGRVIRSDRILHDGLVVPKDTIIGVPVHAISQDADFYPSPS 1260
1261
TFSPFRFVPSTPGEKTAGFVTTNASSSLSWGYGKHACSGRFFAAN 1395
*IKLIMAYFLLNYDFQFAGDRTERPANYSFELQNMPDETVEVLVRRRKDRDL* 187174
>CYP654B1 Aspergillus oryzae
GenEMBL
BAE64653.1
40% to 654A1
just upstream of CYP682B2
286826
MDLFPRDYLFAGLAVFIFWWIIDHSRHKQRYIRNVPIVGGKANLKRNRQKFVTNSLQILRTGYEE (0) 287020
287082
NNDELFYVPTPIGERLIIPGRYLEELKSADMAVVDFQATFLE (0) 287207
MFEGAYTTLGTHSRLLPQVVRAQLNQYLPDVLPEIQFKVALQIHREIPFNAITECFAKSDWTVINVTELM
AVLVARVSSRMFGGPALSQNREWIEASLRFAHDGFNAAQKLKMWPDTLKFIGQHFIPEVRSIKNTYKIAE
RAIIPLLDEREVDKSKKAHDLLTWMYDQAQGAEKDKKFIAGTLLKVSFAAYHTSAAAPTQLLFDIAAMPE
HIAPLLGEYLSAPRDNNQNISVKGFAQMVKLDSIMKESQRFNPLLLLTFERIIKRDFTLSDGVVIPANTW
IGCAAQAIGMDRKLYPDPDTFDAFRFVAKEEATATSTSVPATKAHYTSANPGSMAFGYGQHACPGRFFAM
MEIKAIIGEILSRFEMRLADGEMRPPSVTFETQHLPHPAGKVLFKRRRCT
>CYP654B1 Aspergillus flavus NRRL3357
GenEMBL
AAIH01000140.1
99% to
CYP654B1 Aspergillus oryzae
AFL2G_04897
MDLFPRDYLFAGLAVFIFWWIIDHSRHKQRYIRNVPIVGGKANLK
RNRQEFVTNSLQILRTGYEE (0)
NNGELFYVPTPIGERLIIPGRYLEELKSADMAVVDFQATFLE (0)
4806
MFEGAYTTLGTHSRLLPQVVRAQLNQYL (2)
PDVLPEIQ (1)
FKVALQIHREIPFNAITECFAKSDWTVINVTELMAVLVARVSSRMFGGPAL 5162
5163
SQNREWIEASLRFAHDGFNAAQKLKMWPDTLKFIGQHFIPEVRSIKNTYKLAERAIIPLL 5342
5343
DEREVDKSKKAHDLLTWMYDQAQGAEKDKKFIAGTLLKVSFAAYHTSAAAPTQLLFDIAA 5522
5523
MPEHIAPLLEEYLSAPRDNNQNISVKGFAQMVKLDSIMKESQRFNPLLL (1) 5669
5722
LTFERIIKRDFTLSDGVVIPANTWIGCAAQAIGMDRKLYPDPDTFDAFRFVAKEEATAT 5898
5899
STSVPATKAHYTSANPGSMAFGYGQHACPGRFFAMMEIKAIIGEILSRFEMRLADGEMRP 6078
6079
PSVTFETQHLPHPAGKVLFKRRRRT
6153
>CYP655A1 Aspergillus nidulans AN8411.1 33%
to 52F1 52 clan
aspyridone biosynthesis
Nature Chemical
Biology 3, 213-217 (2007)
doi:10.1038/nchembio869
Genomics-driven
discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Sebastian
Bergmann1, Julia SchŸmann1, Kirstin Scherlach1, Corinna Lange1, Axel A
Brakhage1,2 and Christian Hertweck1,2
MSLASTLPRASFETLLQHTNFMDGIKFVFFAFVVYSCFTIAVGWVVYEWK
RKAHGCGKIPRYPHRDPFFGFDIVFGMAKSLRNDYFLVWLNKVHENLPKT
FLVNFVGTRFIYTIEPENMKSMSAINWQDFAVGPMRRNNKATAPFADKGV
NTVDGHEWEFSRFLIKPFFKRETFTDTSRLTLHVDRVLEQLPADGETVNI
QPLIQRWFLDVTTASLFGESIESLVYPERAPICWAMVDVLRGLRLRLQWY
KYLWLFRHQAWLDAVEVVHRYLNAHIDRTYKELDEYKRQGKNPEAADRND
LLWYMASNLQDKEALRSQICLIFVPNNDTTSIFISHILWNLARHPGIYEK
CRQEVLALGDAELSFSVLRNMKYLNAVLNETHRLFPNGVTQVRKCIRDTT
LPVGGGPDGKQPIFVRKGDVVQVNKNVIHRDHDIWGPDAEDFRPERWENL
RPYWNFVPFGGGPRRCPAQMLVTAEASYFLARLMRVYKRIEARDPNPYVG
VMRVGPSNKTGVHIALFKE*
>CYP655A2P Aspergillus oryzae
GenEMBL BAE65179.1, AP007171.1
pseudogene
60% to
655A1 partial C-term seq
14
P450 genes and 2 pseudogenes on this contig
1863432 QGDVVQVNNNVMHRD
KDVWGEDADEFKSERWFGLRPYWDFVPHSGGPRRYPAQLLVTTEASYVVARFCQRSKAVENRDVNGYIPI
MRAGPVDSNGVKIAVTPV* 1863121
>CYP655A2P Aspergillus flavus
Supercontig 5: 1921861-1922169 -
95% to CYP655A2P Aspergillus oryzae
QSDVVQVNKNVMHRDKDVWGEDADEFKSERWFGLRPYWDFVPHSGGPRHYPAQLLVTTEA
NYVVARFCQRSKAVENRDVNGYVPIMRAGPVDSNGVKIAVTPV
>CYP655A3 Neosartorya fischeri NRRL 181
DS027697
join(287915..288538,288596..289115,289183..289287,
289332..289600)
88% to
CYP655A1
adjacent to
a PKS similar to FUSS polyketide synthase FusA
FusA is used
in Fusarin C biosynthesis
NFIA_001540
Note: this
seq does not have an ortholog in A. fumigatus
MMSLATTLSKESLQTLLQHATFLDGIKFVFSAFVIYSCCIIAVD
WIVYEWKRKAHGCGKIPRYPHRDPFFGFDVVLGMAKALRNDYFLVWLNKVHENLPKTF
LVNFVGTRFIYTIEPENMKSMSAINWQDFAVGPMRRNNKATAPFADKGVNTVDGHEWE
FSRFLIKPFFKRETFTDTTRLAIHVDRIFGLLPADGETVNIQPLIQRWFLDVTTESLF
GESIESLVYPERAPICWAMVDVLRGLRLRLQWYKYIWLFRHQAWLDAVDVVHKYLNAH
IDRTYKELDEYKRQGKDPETADRKDLLWYIASNLQDKDALRSQLCLIFVPNNDTTSIF
ISHILWNLARHPEIYEKCRQEVLAVGDAELTFSVLRNMKYLIAILNETHRLFPNGVTQ
VRKCIRDTTLPVGGGPDGKQPIFVHRDIWGPDAEEFRPERWENLRPYWNFVPFGGGPR
RCPAQMLVTAEASYFLARLMRVYKRIEARDSNPYVGVMRVGPSNKTGVQIALFKD
>CYP655A4 Uncinocarpus reesii
58% TO CYP655A1 Aspergillus nidulans
UREG_06496.1
MGFTRWVFELPDVTFDMVPKWSYLFYFIFFFVITKSATSSISRSLAERRKGYGSVPRYPQLIPIMGFDIAFSMAKSLRNH
TFLLWLRMLHDTIPGKAKTFSIDFLGRHMIHTIEPENMKALSATVWKDFGVEPLRRSTGASMPFADKGVNTTDGHDWAFS
RFLIKPYFLREAFSNTDRLKVHTDNLLSLIPQDGSTFDMQTLMQRWFLDTSTNFLFGESMGCLLYPERAEIAWAMTDILR
GLRLRLQMSKWLWLFRWKVWFSAIDVVHDFIDRQVDRAYSERADAAKGQKQSSFGVELKPERTDLLWSMVGNVPEDRERL
RSEMLLLFVPNNDTTSIFISNVFWNLARYPEVYAKVREEVLSIGENAPLTYEALRAMKYLDAVLNETHRLYPNGIMQVRY
CIKDTTLPLGGGPDGQSPIYVRKGDVVQVNKNVMHRDKDVWGEDADEFRPERWFGLRPYWNFVPFGGGPRRCPAQLLVTT
EASYVVARFCRRFKAIENRDSKGYVPVMRAGPVNTNGVKIAVTPV
>CYP655B1 Aspergillus oryzae
GenEMBL
BAE56825.1, AP007154.1
49% to 655A1
C-term in gene model is wrong, revised
MNNAISEPRITPSLRPSPKMQAPTLTSASAEGSDTTAHGCGGCTHFACQPIIMFTLTEYFIAACVWLVLY
KVGNLLWNRHH
YFKQQKARGCGEIKHYRHRDPILGLDFVYTLSKAFKEHRWLPWQQELFAAQGVKTFQAN
FLGSRAIYTSESENMKAMSTTYWREFGLEPLRRGSGAADPVAGPGVSTVDGPMWDFSRNIIKPYFTRDGY
SNLARLEVFVNRLLDLVPTDGSTFDMQPLLQRWFLDTSSEFLFGKTVDSLTHPENVKVAKAMVDTMRGIR
VRLTMSKLMFLHRDPVWMENVKIVRDFVDERIDASLTQLQDVKSGKGTSCTENQPDGRTDLLWDMVQQLQ
DKEALRGQIMAVFIPSNDTTSILISNAIYALARHPHVYQTLREEVLALGDQEITFEKLRG
717492 LRYLRYVINE (1)
717406 THRLYPNGIQMVRIALEDTTLPVGGGPDQSQPIF
717304
IQKGDIVHANRYLMHRDPDNWGPDAEVFRPERWGDVRPLWKFVPFGGGPRICPAHVLVDT 717125
717124
EASYVLLRFVQRFRTLEPRDERPYKAIMRIGPSNLHGVNVAVKTA* 716987
>CYP655B1 Aspergillus flavus
100% to CYP655B1 Aspergillus oryzae
AFL2G_07514
MFTLTEYFIAACVWLVLYKVGNLLWNRHHYFKQQKARGCGEIKHYRHRDPILGLDFVYTLSKAFKEHRWLPWQQELFAAQ
GVKTFQANFLGSRAIYTSESENMKAMSTTYWREFGLEPLRRGSGAADPVAGPGVSTVDGPMWDFSRNIIKPYFTRDGYSN
LARLEVFVNRLLDLVPTDGSTFDMQPLLQRWFLDTSSEFLFGKTVDSLTHPENVKVAKAMVDTMRGIRVRLTMSKLMFLH
RDPVWMENVKIVRDFVDERIDASLTQLQDVKSGKGTSCTENQPDGRTDLLWDMVQQLQDKEALRGQIMAVFIPSNDTTSI
LISNAIYALARHPHVYQTLREEVLALGDQEITFEKLRGLRYLRYVINETHRLYPNGIQMVRIALEDTTLPVGGGPDQSQP
IFIQKGDIVHANRYLMHRDPDNWGPDAEVFRPERWGDVRPLWKFVPFGGGPRICPAHVLVDTEASYVLLRFVQRFRTLEP
RDERPYKAIMRIGPSNLHGVNVAVKTA*
>CYP655B2 Fusarium oxysporum
59% to CYP655B1
FOXG_14589
MSSRLSAISLAAFYGLVILYFLNRLWDHISYSIKTKKYKCGPLKTYPHWDPIWGIDFVLSMSRAFKEHRWLSWMEETWSA
QGTKTFKARFLGMRMVYSSEMENMKAMSTSQWEEFVLEPIRVDNGVATPFTGKGVSTADGEFWHYSRGIIKPYFERQAFA
NVARLKPFTDKMLDLIPTNGDTFDMQVLTRRWFLDTSTEFLFGKSRDCLTYPEREDVMLAMVDIMRGARVRLTMSKFMFL
HRDPKWYESIRFVHDFMNEYIDQAYDELHLRKEQGEKFADKPERTDLLWDMVQKIPSEDRILLRDQITAVWVPSNETTSI
HISNAIYQLARHPDAWEKLQKEVLDLGDEELTFSKLRGMKYMNWVINETHRTIPNGIQMIRVAAHDTTLPRGGGPDGKQP
IFCAKGDIVHCNRYLMHRDPDYWGKDAAEFRPERWDGLRPLWHFVPFGGGPRICPAHILVATETAYVLTRFCQKFKGIEA
RDERVYVPVMRVGPSSLNGIKIAVTPR*
>CYP655B3P Neosartorya fischeri
51% to CYP655B2
NFIA_045730, NFIA_045740 join
Note: this seq does not have an ortholog in A.
fumigatus
MFTAPLSIAILSITLLYWVVRVYLNYLRYERTAAQFGCPPLKHYPGWDRILGLDYVYAMFKALKEDRFLEFQTETYSARG
SKVWTANFMGNRMVYSSEPENMKAMSTLQRDCFAVEPIRVANGAITPFTGRGVSSSD
GAKWQSSRDLVKPYFKHEGFSNLERLSQHVDRLLSKIPTDGSTVDMQPLFQQ* (0)
FLDTSTDFLF*ETVNSLDNPERDWPHRDMVTVMRGLRLRLQLSSFLFLHRDKEWFATCKR
IHGFLDGYIDKAYKHLEYEKSGKPATYANGEP*DDFLWTIARQVPDKLELRTQLTSIW
IPSNETTSILMSNTLFALARHPEVVEKLRKEILDYGDKPLTFEGLRFMVYLRWTINE
(1)
SHRLYPVSLQTVRSCVKNTTLPTGGGDDGKAPIFCAKGDIVHCNWYLMHRDPDLW
&
GADAEQFRPDRWEKVRPMWNFVPFGGGPRICPAHIMVDTECSYTIFRILHHFKAIEARDSEPYTAIMRV
&
SPSNKNGCRVAFIPA*
>CYP655C1 Beauveria bassiana
AM409327
Chembiochem.
2007 Jan 11;8(3):289-297
Biosynthesis of
the 2-Pyridone Tenellin in the Insect Pathogenic Fungus Beauveria bassiana.
Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey AM, Lazarus CM, Simpson TJ.
Gene name tens1,
52% identical to CYP655A1
44% to 655B1
MLPLLDSVSLPYLILSACLSVILLRRFLAHDKGGSKSIAQGCLP
EPRLRQWDPIFGFGIVISQARALRGHRYLEWLRDLHASMPHTKTFSANYGGYRWIFSI
EPEILKAVYATNLQNFGVEPIRQHPPGFQPFAHKGVSTSDGDDWSFSRTLIKPFFERS
VYISTDRIKPFADKFMTLLPDDGETFDIQPLLQRWFLDITSEFIFGKSQDSMTHADRA
EVTWAMADVLRGGRQRAQTHRILWAFNWDWWFEAVEKVHGFLNPYIRSTLKELEERQQ
RIKDGLPVDEERTDLLWSMATMLPDEEELRSQVCLIFVPNNDTTSMFIGHCLYFLARN
SNAWKRLRDEVDAVGDAPITFEMLRNMKYLNGILNETHRLIPNNVTQVRAALSDVVLP
LGGGPNGKAPLDVRKGDIVSVTKTVMYRDPEQWGPDANEYRPERWDGMRGGWHFLPYG
GGPRRCPAQMMVQNESAYMLFRLAQKYSTIVARDPEPFRARMRIGPSSMHGVKIAFYK
>CYP655C2 Fusarium oxysporum
55% to CYP6455C1
FOXG_14594
MALHQLLAQQVTTRNLPILAVGAAFLIFIFRKLFTSSQKSEAKGWKPIPRYWQWDPIWGLDLVASQIHALRSNQFLAWLS
KLHASMPHTKTFSINMFGVKWIYTYDPEVLKAVYATHFKEFGVTPIGNLRRGLTPFADKGAITTDGEDWKHSRFLIQPFF
DRQVYTSTDRVARHTDQFIKLLPDNGETVDLQPLLQRWFLDIATEFIFGESTEALVYPERAKIANTMLDVLDGGRLRAQL
NRLMFLRDWTPWLKSVEEIHAFVTPPIQETIKEKHEREKKTKEGATDLEPERTDLLWTMVQNLEDVEELRSQICLILVAN
IDTTSVFISNCVWWLARYPDVWDKIRQEVHELGDIPMNFSVLRNMKYLNCVMNETHRMIPNNVSQLRGAFEDVVIPVGGG
PDGKSPTLIRKGDLVLINKTVMYRDPEAWGEDSNEFKPERFDGYRGSWGFLPFGGGPRRCPAQMMVQTEAAYILAHLAKT
FKRIEPRDPEPYVPVMRIGPSNKTGVKVALYR*
>CYP655D1 Fusarium oxysporum
43% to CYP655C1 Beauveria bassiana
FOXG_03951
MSNSTGFIADLPGLFTDIPGYVADIPSRIDFTSIPVILSSTVAVLAFTSFVKYVAERQQEKAMGFGHVPTLWQLDPFYGF
DAFVAMLLALKNNRYVPWLDSLHAKMPKTFALTFLGGRQIWTIEPENLKTVANNLADFQVGPIRYNSKAGQPFAEKGIVG
ADGKDWEFARALVKPFFMREWYANTERMEPFAERFFAGIPADGETFDMFPHLRTWSLNLNLQFLFGDYSDIVTEEETNNT
TDAFITGLAYARIRLLLHRVLWLFPWKTWYKVVGTIHSYVNKHIAKARAELKEREERISKGLPVGPERRDVCWHMVRELP
NDDEVRSHLCLLFVPNNETTLIFLSNVMWNLARQPEIWERLRQEVKGKELNFNSLRGMKLLQNVLTEAHRITPVGLFIAR
AAVRDTTLPRGGGPKGDQPVRVRKGNIVQINKAVMYKDPDYWGDDALEFNPDRFDKMRPGLSLTPYNTGPRRCPGEMMTM
NECGYMVARMAQTYKRLECRDPTPFVGAFRIGQLNKNGCQVAVYRE*
>CYP655D1 Fusarium verticillioides
96% to CYP655D1 Fusarium oxysporum = ortholog
FVEG_11928
MANSTGFMADLPGLFTDIPGFVADIPSRVDFTSILVILASTVAILAFT
SFIKYVAERQQEKAMGFGHVPTLWQWDPFYGVDAFIAMLLALKNNRYVPWLD
SLHAKMPKTFALTFLGGRQIWTIEPENLKTVANNLADFQVGPIRYNSKAGQP
FAEKGIVGADGKDWEFARALVKPFFMREWYANTERMEPFAERFFAGIP
ADGETFDMFPHLRTWSLNLNLQFLFGDYSDIVTEEETNKTTDAFITGLA
YARIRLLLHRVLWLFPWKTWYKVVGTIHSYVNKHIAKARAELKEREERISK
GLPVGPERRDVCWHMVRELPNDDEVRSHLCLLFVPNNETTLIFLSNVMWNL
ARQPEIWERLRQEVKGKELNFNSLRSMKLLQNVLTEAHRITPVGLFIAR
AAVRDTTLPRGGGPKGDQPVRVRKGNIVQINKAIMYRDPDYWGDDALEFNP
DRFNKMRPGLSLTPYNTGPRRCPGEMMTMNECGYMVARMAQMYKRLDCR
DPTPFVGVFRIGQLNKNGCQVAVYRE*
>CYP656A1 Aspergillus nidulans AN6321.1
related to CYP52 52 clan
MSAVLLGKRYVSTPDPENIKAVLATKFVDFDLGERNAAFRPLLETGVFTQ
DGREWERSRALLRPIFNRAQALPDLLLIEEHVQSRLYRIPRGYDIVNLQQ
LVRDLTLDSAFIHFLA (1)
GRPAKIAGSRRGDFDAEPFSHAFDEARSYLQVRANLGPFRGLVKNTKFVD
DVIVHAAVDEFVYEALEQRRSPAHENRGKLGRGCGN
ESESEGWYDLLSKVADTVSDGVQIRSQLLHVLLAARDT
TARLLSSVFYMLARHPSVWRKLEREVLVEFGLATQGDGKCPLPTYTQLRE
MKYVRAVLNE
ALRLLPPVPTNIRCATQHTFLPRGGGVDGCQPIFVAKKAIVHYS
(?)
AEQFRPERW (2)
VPLRRGW
GFLPFSGGPRICLGQQKALTEAVYVVVRMVQTFCDIEARDERPWREQMG
LVLSSYYGVKVGLKSRNGGS*
>CYP657A1 Aspergillus nidulans AN5137.1
similar to CYP8 27% to 641A1 cyp7 clan
revised 7/18/07
MNTIQGAYDGLQPKTLVLAAIYILICV
IIFTRILTGLQSYKKTDTAQPRRPRTAPYWIPWFGHSLSFARNHIEFLEN
TRHRLNETVFAIVMSGAKHNVVMSPSMIKSVLTFRGVTTAPLVQHVSRNI
LGDRGVFQKLNPSDRHVFVHNVPNQFMHEPSLSQTSGAAARFIERETPNL
VTFSAAPIDQMLWERPGDVTVIEGKGQQVCEVDFFALIRYFVGTVTTTSL
FGQAILDTFPTLLQDVWSVDDQFATLSMGPPRYLTPGISAAYMARDRLLD
ALAIFHQALLLWDEGKDLGMEFRDLRDLEDVSEPIKNRARMAKDMGLTPQ
ESAPAHLALLWAMNGNSPNIVFYHLLHLYANPTLLEDLRKEIAPFVKVSR
PTREETGFPILEAPRLSIDIDKLCDSCELLKASFYETLRLDSAGLSFRQL
TADLTITESEEEASKAGRLTPESYSLKNGELVIIPHGVIHNDPTHFSNPD
QFDPLRFIRTDPQSGQKYAKSETMTPFGGGMPACKGRAFAEKKILALSAA
IISLWQITPAEGKKFKIPEHRISSAAFLPKNDIRVRMSPRYPS*
>CYP657B1 Aspergillus fumigatus Af293
XP_750481.1
also EAL88443.1
51% to 657A1
MDDVREWIWPILLAILLSSCLATRIITGLKSWPDKRIDARLPRSVRVVPYWLPWLGHSIPFGWDHIDFVR
RARDY MNEAVFGIILGGLKHDVVVSPSLTKAILASRGTSSNALINYALEKVGGDQGAIRSLSATDHHIIH
HNIPNLLMREPFLTEASKVAKDITEREAPNLVTFCRSMVDQAPWERRSEAEVTDGQEKLMAEVNLFALVR
NFVGHISTSVLMGQAFLEAFPDLLDDMWTFDNRFPVMALGAPRWLPLPGLSAAYAARDRILDALAAYHQA
FVSWDEGNDPGVKFRDLDDVSESMKQRIRKFKELGLSPRSSAPGHLSLFWALNANSPNVVFWNILRIYSD
PALLEEVRKEIAPFVKVYRPSREETGLPFQEPVKVSLDPDELFRSCPLLKASFYETMRLDSAGLSFREVT
SDLTVTESPEDAAAASLAEPRTYRIKKGGNIVMAHGMVQRDPRLFSNPEQFDPLRFVVTDPDTGARKADM
HTIYPFGAGVSGCKGRALAERMNLLFTAAIISTWDIEPASGKALTVPGHRPSSGAYLPKDDIRVRLRMRV
>CYP657B1 Neosartorya fischeri
94% to CYP657B1 Aspergillus fumigatus = ortholog
NFIA_017390 revised
MDDVREWIWPTLLAILLSSCLATRIITGLKSWPDKRTDAQLPRSVRVVPYWLPWLGHSIPFGWDHIDFVRRAR
(2)
DYMNEAVFGIILGGSKHDVVVSPSLTKAILASRSTSSTALINYALEKVGGDQGAIRNLSATDHHIIHHNIPNLLMREPFLTE
ASKVAKDITERETPNLVTFCRSMVDQAPWERRSEAEVIDEQEKPMAEVNLFALVRNFVGHISTSVSMGQAFLEAFPDLLD
DMWTFDNRFPALSLGAPRWLPLPGLSAAYAARDRILDALAAYHQAFVSWDEGNDPGVKFRDLDDVSEPMKQRIRKFKELG
LSPRSSAPGHLSLFWALNANSPNAVFWNILRIYSDPALLEEIRKEIAPFAKVHRPSREETGLPFQEPAKVSLDPDELFRS
CPLLKASFYETMRLDSAGLSFREVTSDLTVTESPEDAAAASLAEPRTYRIKKGGNIIMAHGVVQRDPQLFSNPEQFDPLR
FVVTDPDTGAQKADMHTIYPFGGGVSGCKGRALAERMILLFSAAIISTWDIEPASGKAFIIPGHRPSSGAYLPKNDIRVR
LRMRV*
>CYP657B2 Aspergillus oryzae
GenEMBL
BAE61082.1
52% to
657A1, 60% to 657B1
MGKDGLSTDGLIQNAWSGSSELVWPLLATVLVLCCIATRIISGFQSRVDSKTEQPQSVKTLPYWFPWLGH
SLSFVWDH VSFTEKSRDYMNASVFGSYMGGTK HNTIVSPSMIKSIMQSKATTSAPLVNRALKAFGDDLGS
LRDLNTTDYQVFHHKLPNLLMREPFITEASETTIQLLKREVPNFVTFCRSVVDQTLWERGSDVEVVDDNG
DKPACEANLFDLVRGFIGNITTTTLMGQAILEAFPSLLDDLWVLDNRFPLLAIGVPRWAPLPGVPAAYAA
RDRILNSLAAYQQAFLQWDDGIDPGVKFRDLEDVSEPLKQRIRTSKNLGLSPRSSAPGHLSLLWAMNVNS
SNIAFWYLVRLYNDPTLLEEIRKEISPYVKAHRPSREETGFPFEEPPRISLNLKGLLDSCPLLKASFYET
LRLDSADMSFRKLTSDLTITESNEDVTNSDRTKPHSYKVYKGESLILHHGVLQNDSRCFSNPSQFDPLRF
IITDPETGEKKANMHTIHPFGGGMSGCKGRTFAERQLLAFTAAMIVMWDIEPMDGSHFTVPRHRQSSGAY
LPKNDIRGKTLWNVNNHGVVVFIRGGRHYLAPPMADRDLSFCITCRIYIVQNIHI
>CYP657B2 Aspergillus flavus
99% to CYP657B2 Aspergillus oryzae
AFL2G_03848
MGKDGLSTDGLIQNAWSGSSELVWPLLATVLVLCCIATRIISGFQSRVD
SKTEQPQSVKTLPYWFPWLGHSLSFVWDHVSFTEKSR (2)
DYMNASVFGSYMGGTK
HNTIVSPSMIKSIMQSKATTSAPLVNRALKAFGDDLGSLRDLNTTDYQVFHHKLPNLLMREPFITEASETTIQLLKREVPNF
VTFCRSVVDQTLWERGSDVEVVDDNGDKPACEANLFDLVRGFIGNITTTTLMGQAILEAFPSLLDDLWVLDNRFPLLAIG
VPRWAPLPGVPAAYAARDRILNSLAAYQQAFLQWDDGIDPGVKFRDLEDVSEPLKQRIRTSKNLGLSPRSSAPGHLSLLW
AMNVNSSNIAFWYLVRLYNDPTLLEEIRKEISPYVKAHRPSREETGFPFEEPPRISLNLKGLLDSCPLLKASFYETLRLD
SADMSFRKLTSDLTITESNEDVTNSDRTKPHSYKVYKGESLILHHGVLQNDSRYFSNPSQFDPLRFIITDPETGEKKANM
HTIHPFGGGMSGCKGRTFAERQLLAFTAAMIVMWDIEPMDGSHFTVPRHRQSSGAYLPKNDIRGKTLWNVNNHGVVQNIHI*
>CYP657B3 Aspergillus clavatus
72% to CYP657B1
ACLA_027250
MGDPGVFSSSLLQSLLSNDPRELIWPTLLAIIVFSCLATRIITGFQSWPEKGAGAGLPRLIRTVPYWVPWLGHGISFGWD
HVVTHQESRNHMDEAVFAIIMGGTRHNIVVSPSLARAILSSRSTSSVSLINYALEKIGGDKGAIRGLSSSDHHLIHHNNP
NLFMREPFLTDASKDATSLIERETPNLVTFCRSMVDQAPWERGSEAEVIDGHDKPISTVNLFALVRNFVGHITTSVFMGQ
ALLEAFPDLLDDIWVFDSHFLALSLGAPRWLPLPGVSAAYAARDRILENLAAFHQAFVSWDDGNEPAVEFRDLEDVSEPV
KQRIRKFKELGLSAKSSAPGHLSLLWAMNANSPNAVFWHILRIYSDPALLEEVRKEIAPYVKVSRPSREETGFPFLEPPK
ISLDSDGLFKSCVLLKASFYETMRLDSASLSFREVTTDLTVTESLEDAAAAGLTQPRTYAIKKGENVSVVHGAVQRDPRF
FSNPDQFDPLRFVITDPETGEKRAEMHTISPFGGGVSGCKGRAFAERKILLFSAAIISMWDIEPVEGSEFKIPRHRRSTG
QFAPKNDIRVRMSTRV*
>CYP657B4 Aspergillus terreus
61% to 657B2
ATEG_10169.1
MLSALLYVYLPPGAMGEYEITKDVLIQTARNNLTALGWTALCAAALICIITRVITGLQSRTDGSSKTSDVRPVRTVAYWI
PWLGHGISFVWDHISLIEKARDSLKEPALGIYMGGTKHNVVVSPSLVKAVMLSPSTSSVAWINYALKTVGGDRGPIRNFN
AADHHVFHHDLPNLFMREPFITEASTKLVELLKREIANFVTFSWSPVDQAPWERSSDAVLTDRSDKPVCEADFFALIRGF
VGHITTTTLMGRAILEAFPRLLDDVWELDNHFPLMAMGLPRWLPFSGLPAAYAARDRILEVLAAYQKAFLDMENGIDGDV
KLRDLDDASEPVKQRIRMSKNMGLSPHDSAPGHLLLLCAMNGDSPNVAFWHLLRLYTNPALLDDIRQEIAPYVKAWRPSR
EETGFPIPEAPKVSMDFEAMLKNCHLLKASFYETMRMDSAGLSFRELTSDLTITESKDDAAVAGVEEPRSFRVNKGESIA
VPHGVLHNDPRYFSNPGQFDPLRFLVTDPETGAKRAELHTIDPFGEGASGCKGRVLAEREILAFVAAIISMWNIEPADGK
EFKLPKHQPSRGAYLPKNDIRVRLSMRV*
>CYP657B5 Aspergillus niger
estExt_GeneWisePlus.C_50091|Aspni1
Supercontig 5: 118325-119770 (+) strand
60% to CYP657B1, no introns
note name typo: called CYP675B2
WPAIVAILVSICVVTRLITEFQSRPRGISEGRPRPVRTVPYWLPWLGHGPA
FAWDHVDLLQKSRFSMKEAVFGIYMGGTKHDIVVSPSMVNSVLTARGTSSTDLINYALEKIFGDRGVIRNLNPVDHHTLN
HNIPNLLMREPFLTEGTRNATRLIEREIPNLVTNCRSIVDQMLWERGSQAIVVDGEDSLACEVNFFALIRRFVGHVTTAI
FMGEAILEAFPALLEDVFTLDNQFVLLSMGIPRLAHPGVSAAHVARRRLLDSLTAYHQAFVSWDDGIDPGLTFRDLDDIS
EPIKERIRKCKELGLSARSSAPAHLSLLWAMNGNSPNVVFWHLLRMYASPTLLEEIRKEVAPYVKIVRQESGFAFLEAPK
LSIDTEALVKSCPLLKASFYETLRLHSAPLSFRGVTADLTITESAEDAAIAGVAQPRSYELKRGDTVAIPHAVLHTDPKY
FANPRDFDPMRFISTDSETGQRKANVHTIKPFGGGVSGCKGRAFAERKLLAFAAAIITMWDVKPAQEGGFTVPEHRPSGA
AYLPRKDVRVRITQRA*
>CYP657C1P Uncinocarpus reesii
40% to CYP657B1
model is missing the heme signature
UREG_03228.1
MENAFGARRSTRAFNRASFHADSGPIQFLSKDPWLTDVSSSLVREVQKAMPNLLSFSPSVV
DQSTWERLSDVYYKQEDGG
PVCEVGLFSLVRNFVGMISTTVIMGTAFTETFPYALNELWAFDSRFNAVLLGIPRWVPFPGLVTAYAARRRLLLALKSFH
NGLAASETGVDAGFDWRDMDDVSEVIKARSRALTDAGYTAEQAACEHLAFFWAMNMTTNTMIFWNLVHILLDKQLKQEIM
EEIKPHSKVTRSDWGESGFSIPEPPRLHIDAAALVSACPLLKATYYESIRVYATPLSYRQLINDITLSEPTATTTVATSR
PNTYKCDAGSYVAVPHFMHNMDPKSFPDPEDFRPWRFL
(heme region is missing )
PEKSEETSDVSDEDLSLEDEKLIADD
ESISQKMRDVWPREGSTILSYSPE
FAERQALIFTAAFLTMWDIEQADGKAWKVPRPTDGSATCVPRKDIKVRMKLRV
>CYP657C2 Coccidioides immitis
66% TO CYP657C1P, HEME SIGNATURE IS MISSING
note C is found adjacent to the AG pair in the
I-helix
This may sub for a Thr that points to the
heme. Cys on the other side of the
heme?
CIMG_02482.2
BOTTOM PART IS SEPB, A CHROMOSOME SEGREGATION
PROTEIN, NOT P450
MAAALLKQSSSLSTEPATDYILKNAFGAGRSVGTLNRSDFYGDSGPIQ
FLNKEPWLTDITSAIARQVQQAMPNLLSFSPSVVDQSTWERVSDVSISHENGEPICEVYLFALVRNFIGTISTTALMGSA
FTETFPYALNELWNFDGNFNAILSSIPRWIPFPGLVSSYSSRRRLLLAMKVFHDAFAATEIGVDPGFDWRDMDDVSEVVK
ARSRALIEAGCSAEAAASEHLAFFWAMNTITNTLVFWNLVHILSDEELHEKILEEIAPYSNAARPDWRESGFNIPEPPRL
RLDANALVSSCPILKATYYESLRLYSLPLSYGQVTKDVSLAEPTVVDSPSSTYKCEAGTYVAIPHFIHNMNTDSFHEPTK
FDPQRIFPHDLEKD
(heme region is missing )
SDTPDNYESSENEKLISN
DSISQKVNDIWPSEASPVLGFSRE
FAEGQALVFTAAFLTMWDIQRASGRRWTVPRQKAGSAVCVPRNDVMVRMKLRV*
>CYP657D1 Histoplasma capsulatum G217B
43% to CYP657C1P
ABBT01000229.1 Ajellomyces capsulatus G217B
HCB07501.1
176305
MERVFGAQENTRNLTREDFDAQCRLMEFQMREPFALNCSSIALRQIEQNIPNMLSFCSSIV
DQSLWERMSAVSLVSDGNGQACEVNLYTLVRNFAAVTVMSAIMGEDFMEALPNTPD
DIRTFNNNFNAIVLGIQRWVPFPGLPTSYRSRRRLLQGMEAFHSAFEVAENGHDPGFDWRQIDEASEFIQSHCRTWKNAG
LAASSMASESLALLWAMDTKLNTIICWNLIYILADGPTHSQVMKEIAPYSRAGRPNSGEAGFQLPEPPRLSLDADRLVDS
CPLLKATYYETLRLHSCPVTYQKITEDFKLTESAADAKIANRKQQTYEFRKGEYIAIPHALHNTDSHYFGDPEEFYPERF
LMQKD
(heme region is missing )
VDSNKPSGKGATSEKR
ESLSQPELKIPEIWTVESGGGDTVIQDGK 177525
177526
FAERVTLGFVSGLLAMWDIQPVKGMGWKIPKQSTGGLVYEPKTDIRVRIKSKV* 177687
>CYP658A1 Aspergillus nidulans AN8438.1
poor match 26% to 640A1 7 clan?
MPPYVIVSELLLIRLVCGLVGYVLWRLWRFTVHPLLQPNLPRELPYTIPF
IGKDLRPSQTIQSTDSLRPCNFPATEPARFNIVYHDALEVLRDRPEVINT
EHIKDLLHGLGCSKPGILEIDSHQRGNISVPDSKAALTNRPPLFKVAEGL
LSKQLLDRSLGNDLLARTLEVLETQGIPQVSLMIMSRWTNDLWKLLFKVP
EPFARDVYTARTRVQRCLQEFLRLPESEKSDQSWAIEAAVAEMRSRGMSE
ADTASYLLVVFWAINANTFKIIFWLIAHIISNPTILTAVTTEISSILSDW
PSNESLSSLSIRLERNTLLEALHNEAHRLALNTSSARTMKQDVNINGRIF
TSGTHAVIPYRYLAMRHPLLSQDWDAFQPERFLSNPGLGQSKSFLPFGGG
KHKCMGRFLSRRLVLTFTSLFLHRFKVRPLDGVPKMGFRPVSSGPASPVD
DMRLVISHKEY*
>CYP659A1 Aspergillus nidulans AN3349.1
poor match 25% to 640A1
lower half 7 clan, revised 7/19/07
MDILDVASSELYTLVRSLVTSPVCQGVLFSLLT
WRLWRFTISPTLQPEDPKEAPYWIPCI
(2?)
NQLGNTREPFALTLAGKTMYIIADPKDAAEL
IRNSHSLSTLTTELYTRMGIPQAVIERLFTVYPDAPFNARSNARPVHATD
AMIEMYRAHLSPGAQLDEFLERDVTKRILNAFAKIPGLFNK ()
GIVGAYYGDLIFSLNPGFIAQFMVWEKVNWKLLFGLPSFLSGDMLAARKGLVDGFVAYF
ALPRAERGHENYWVKGVEDSLRWLNVSNEDIARIFMLQTWA ()
ILGNMYKMTFWLVAHILHDAALVNAITAEVRPA(0)
IEIDHHYLSEQCPKLDSLFSEVLRLTLTAPMARDVSETTTVGGRRLREGNRVL
(0)
VLYRQLHLDRAT
WGPTPQTLQPDRFLIDSGLKSSIAYRPWGAGKHICPGRFLARSAVFTFVA
YLLAGFEVRLRETGTGKSTRSAFPMADMSRPSPGIANIADGEDVLISVIRRDRSS*
>CYP659B1 Talaromyces stipitatus ATCC 10500
ABAS01000005.1 50% TO CYP659A1
MSSSKFFSLLAPTTDDLSSFFFPSFSIAIGLLLC
WRIWRFSIRPLLHPDDPKELPYWIPCEKSSQSCNRK (0?)
272214 NGSSKEPFAITMAGKPIYLLTNPKDIAETYRHEDTLSMDMVVKDLYSRTGISMDKVNRLFIANPES 272411
272412
PHNKGLPRPLHYIDISMEYFRWELSPGESLDRFVNEAAIPAILKAFDFD (1) 272558
GVVDIYYGPALWKINPDFVHSFMMWERVNWKYIFQLPGFLSKDMLEAKRDLVDTFVTYFE
MDRTERDCGNLFVNSVEDTLREAGMGNEEIGRIFFLHSWA
ILGNMYKTAFWIIAHLVYNPSLLEAIRIEVTPAI
EVDHQYLSKDCILLDSLYADVL
RATMSSPMVRDITETTTIGGKKLRKGNRIM (0)
VSYRQLHLNTDVWGPTPELVQPDRFLRDKSLKTNNSYRPWGGGSTLCPGRFFAKKTIFTF
ISVLLVRYSAIHIKEETVGDNKGGRKPAFPRADFSKPIPGIVSPMMGDDISLILRESD*
>CYP660A1 Aspergillus nidulans AN4117.1 35%
to 636A1 cyp7 clan
MLEPFHLLILGAITAIGYILSQRGLDPREPPEVHSKIPIIGHILGLMRHG
MGYFSRIAAENSSHPIFTINLLTNKQYIVTSPSLMQAVQRNKRTLKFAPL
VNFTAERFAGIPESGMSLLRDREAGGAGLSAGTVHAMEKTLIGPSLDRMN
EEMARMLSPLVDELVASPQTVDLYAWCTRAITAASTNASYGPKNPYKDSA
IADAFWTFETNIAPLITGVFPSIMARKAYRARETTFAAVLTYFQTKGHEQ
GSELTKTRYRVMHAGGLSDTDIARAEVSMGLGLLSNTVPAAFWVLFDLYS
RPSLLCEIRREVMKHAVRVENTQTPMGRKRIIDISALRDSCPLLVSAYQE
ILRTRSVSAVTRVVTEDTVLDNRYFLKKSGVVSIPASAIGATESVWGPES
ASEFNPRRYMRQTTPHGSTSPRRTGGFMSFGVSPTICPGRHFASSEILAL
VAMVILRIDLTPVDDGAWKAPEKNSMAIASGMCPVKGEFWVKVARRESEG
EGVEWAVEAREGSGMFNLMVG*
>CYP660A2 Aspergillus niger
fgenesh1_pm.C_scaffold_22000016|Aspni1
53% to CYP660A1
MLDFYTRLAVLGLLAVFGYAFTRREKPDPREPPLVRSSIPVVGHLLGFLWYGLSYFTMMTEKHAYPIFGLNMIFTKSYLV
TSPSILQSIQRNKKSLSFDPFLSMAAERMVGIRGPTLELMREKQSGGQGLKQAVIHAMQPTLIGASLDRMNERMARLLRP
LVDDLASTSTVDLYGWCRHAITVASTNAS YGPLNPYQDAKIEESFW SFESHLSPLMANFLPWLTARTAWRGREAVVAGLV
RYYEQGGHEDGSEMTQVRWKTMREAGVATEEIAREEVGMGIGLLSNTVPAAFWVLYELYSRPDLLEEIREEIRRNALRVD
ADQRHII DISAIRDNCPLVVSSFQEI LRVQSASAPTRFVMEDVMLADQYFLKAGSMINMPAATLGRMPEAWGETAREFDA
RRYMRSDEKNPRRTGGFMTFGVSPVICPGRHFASSEILGLAALLVLRYDIAPVDGQWRTPRLNSMAVASNMRPLKDEFPV
TVRPRSEYAGVQWDCTVQPGSGVFNLMVG*
>CYP660A3P Aspergillus terreus
51% to CYP660A2 Aspergillus niger
ATEG_00534.1
Pseudogene with defective EXXR = KTLR
Deletion near the PERF MOTIF
MPNIYALTVFGVVSALGYVLNRQQKPDLNEPPNSRQD (0)
(gap, most of N-term missing)
TFESALKPLAMKFLS*LIACK
AWQAHEKVVAALVKYYEIGGQEESSELAFVRWKTLRNGGLPIE
NIARSEVSMTVGLLSNTVPANFWVLFGLYSRPELLEEVRQEVAQKALYTSDNVRILHISTLHDDCPLLLSVFQKTLRTRT
WTSPSRFVPDDFLLTGQYSLWAGSVASMPDASVGRTP
(12 aa deletion)
RRFLTTNEDARRVCGFMMFGASPILCPGRHFASAEILAKAATT
VLLYDLTPMGGVWNVPKINTMAITSVIQPLKGGYEVTVSPRKEYEGTQWACTVREGNGMFNLMVR
>CYP660A4
Aspergillus terreus
66% to CYP660A2 Aspergillus niger with one frameshift
ATEG_00435.1
MLDLYRLVALGAVVALGYALSRRQHRDPREPPVVGSGIPIVGHLLGLLWYGVGYFSLMTEKYTYPIFSLDMVFGKAYLVT
SPALLQAIQRNKALTFDPFLTMSAQRIAGIRGLGLELMREKQSGGQGLNQKVVHAMHPTLTGRPLDRMNERMTQLLSPLV
DELATRKTVDLYSWCSHVITLASTEAS
YGPLNPYKSREIEDAFW (2)
AFESNLSPLTANFLPWLTARKAWKGRETAVKAVIKYYELGGHEEGSEMTYVRY
KTLREGGMSVEDTARSEVTMAIGLLSNTVPASFWVLFELYSRPELLEEVRQEVAHNALRVTADKKHVIDISA &
LRDHCPLLVSVFQEVLRTGSTTSPTRFV
LNDLVLADKYLLRSGSVISMPGASMGRNPDAWGSTAGDFEPRRFIKTDKTPRRTGGFMTFGVSPVLCPGRHFASSEILGM
AAMMVLQYDLTPVDGAWTPPPVNPMAITSITRPIKGGFDVRVSPRKEYEGVRWDCEAQEGNGMFNLMVG
>CYP660B1 Aspergillus fumigatus Af293
GenEMBL
XP_747896.1
43% to 660A1
MDNLSLVVGTLILIAGSALMLRLRHDPREPPVVHNGIPFIGHMIGFVRHGIDYYALQSAKHGLEAFTMDV
LFTKIYVITTPTLVMATRRHHRAMSFEPAITGAARRVTGLKGRGFELLSEKRPGGENLHGAVVNAMRPAL
EGAGLDRMNEKVIGYLLRSVDDLPTAAPFDFHAWCRAALTLSSTDAVYGPLNPYRSKELQDAFWDFEENL
ALLLMDVVQRVTARTAWKARRRLVAAFLDYYRAGGHLDSSQLTYARWETQQKGGATLEDIARLETAAALG
TLSNTVPAMFWFMFNIFSRPELLNEVRDEVARRAVQVDAQGVHTVDLAEIKEKCPLLMSAFQETLRLRSN
TVPIRVIFEDMILDDRYLLKKGGILQMPAHAINRDRTIWGSDADDYDPRRFVKINQSDSRKKANGFLSFG
TSPHVCPGRHFATGEILALIAMLVLRYDIVPAGGVWKEPRTSKSAITSSTGPPAEEFKVLATARKEYEGV
EWAFRVTEGKGKYGLIIG
>CYP660B1 Neosartorya fischeri
94% to CYP660B1 Aspergillus fumigatus =
ortholog
NFIA_048000
MDNLSLAVVTLILIAGSALILRIRHDPREPPVVHNGIPFIGHMIGFIRHGIDYYALQSAKHGLEAFTMDVLFTKIYVITT
PNLVIAARRHHRTMSFEPAITGAARRVTGLKGRGFELLSEKRSGGENLHGEVVNAMRPALEGAGLDGMNEKVIGYLLRSV
DDLPTAAPFDFHAWCRSALTVSSTDAVYGPLNPYRSKELQDAFWDFEENLALLLMDVVQKVTARKAWKARQRLVAAFLDY
YRAGGHLDSSQLTYARWETQQKGGATLEDIARLETAAALGTLSNTVPAMFWFMFDIFSRPELLEEVRDEVAQRAVQVDAQ
GVHTVDLAEIKEKCPLLMSAFQETLRLRSNTVPIRIIFEDTILDDRYLLKKGGILQMPAHAVNRDRKIWGSDADEYDPRR
FVKINQSDSRKKANGFLSFGTSPHVCPGRHFATGEILALIAMLVLRYDIVPLGGVWKEPRTNKSAVTSSTRPPAEEFKVI
ATARKEYEGVEWAFRVTEGKGKYGLIIG*
>CYP660B2 Aspergillus clavatus
69% to CYP660B1
ACLA_098770
MTLSLVVVALLILAISIVGLRHAKHDPREPPIVHNGVPVLGHVVGFIRHGINYYAQQSAKHGLDAFTMDMLFTKIYVITS
PTLVVASRRHHRTMSFEPFITGAAKRMAGLRGPGLDLLREKQFGGKGVHADVMHAMRPSLEGAALDRMNEKMIRLLVESV
DELPTVGSFDFHEWCRSAITIASTDAVYGPLNPYKAKELQDAFWDFEANLAPLLMDFAPWLTARKAWKARELIVARFLNY
YRADGHLDSSQLTYTRWEAQHRGGATVADIARLEAAAAFATLSNTVPAIFWMVFDIYSRPALLEEIRAEVTRHAVHVDAQ
GAHVVDLTDIRENCPLLVSTFQETLRLRSNTVPVRVLYEDTVLNDQYLLKKGGILQMPATTINRAPSIWGRDAAEYDAHR
FIKIHQSSDSRKTANGFLSFGTSPHMCPGRHFATGEILALTAMLVVRYDLAPKSGVWKEPKINLRAVASSTRPPATAVPM
TAMVRKEFEGVQWTFRVSEGKGRYGLIIG*
>CYP660C1 Aspergillus oryzae
GenEMBL
BAE63219.1
61% TO
660C2, 40% to 660A1, 47% to 660B1
revised 3/19/2009
MSDILSIIGLTLLVAFLTSVVFFVQRRKLDPREPPLASSAIPLVGHLASFLYYGLEYFAIAS
(2)
RKNRLPAFTMDMLYTKVYIIASPE
LVSAVRRSRNAMSFGPLFANVAENGGGINGRGMQLLRDKEYGGQGVGQQTADSMHPALLG
SGLDQMNGKMIAVLKTIIDELASQPDNVVDLYEWCSHAVTVASTDAVYGPLNPYRSESNRRAFWAI
ESNL
SLLMMNVVPWITARKPWKGREQLTQAFIQYYQADGHLDSSQLAYTRWKVQHEAGAAIEDIARLEALTALG
ILSNTVPTCFYFLFDIFSRPDLLGKIRDEILDGAFSVDSAGVHTLDLADIRERCPIFVSTFQETLRTRSN
SGQLRVVQKDTLLDDHLLVKAGSIILMPAAVINKHPSVWGADAGTYDPERFSKIDPAQKRSKASGFMSFG
SSPHICPGRHFASGEILALVAMILVRFDVRPVRGTWVEPKGNTKAVAASLPPAVEKVEVKFSETSKFAGV
KWEFRLTPGKGTFGLITG
>CYP660C1 Aspergillus flavus
99% to CYP660C1 Aspergillus oryzae
AFL2G_08647
MSDIPSIIGLTLLVAFLTSVVFFVQRRKLDPREPPLVSSAIPLVGHLASFLYYGLEYFAIA
SRKNRLPAFTMDMLYTKVY
IIASPE LVSAVRRSRNAMSFGPLFANVAENGGGINGRGMQLLRDKEYGGQGVGQQTADSMHPALLGSGLDQMNGKMIAVL
KTFIDELASQPDNVVDLYEWCSHAVTVASTDAVYGPLNPYRSESNRRAFWAIESNLSLLMMNVVPWITARKPWKGREQLT
QAFIQYYQADGHLDSSQLAYTRWKVQHEAGAAIEDIARLEALTALGILSNTVPTCFYFLFDIFSRPDLLGKIRDEILDGA
FSVDSAGVHTLDLADIRERCPIFVSTFQETLRTRSNSGQLRVVQKDTLLDDHLLVKAGSIILMPAAVINKHPSVWGADAG
TYDPERFSKIDPAQKRSKASGFMSFGSSPHICPGRHFASGEILALVAMILVRFDVRPVRGTWVEPKGNTKAVAASLPPAV
EKVEVKFSETSKFAGVKWEFRLTPGKGTFGLITG*
>CYP660C2 Aspergillus oryzae
GenEMBL
BAE56717.1, AP007154.1
61% TO
660C1, 38% to 660A1, 56% to 660B1
revised
3/19/2009
382760
MSGSTTIVGLSVVAILASLLFTQRAKLDPREPPLVSSTIPLVGHLISFLIYGIGYFAT 382587
382586
ES (2)
GKHSLPIFTMSILKQRVYIIASPDLLPSVRQNRSTMSF 382413
382412
NPLFTAMAQRAGGIQKPGLQLLREEELGGQGLAKKTVEVMRPALLGNKLDHLNEQMIHAL 382233
382232
KHIVHQVASSPTLPFDLYEWCSDALTVAS TDAIYGPLNPYKSEAIRKAFW (2)
DFESNLSLLLVDTLPWLTCRKAWKG REQLVQAFIQFYQADGHLSASSLAYSRWKAQQEAGASLEDIA
RLEILTGIGILSNTVPSCFWLLFDILSRPELLSAIQDEIHQNALSIDSTGTHTLDLADIRGKCPTLLSSF
QETLRTRSNSGQVRVIYQDTLLNDRWLLKAGSTLLIPAPSINKNNSTWGSDAGDFDSQRFTKIAHQTHKK
SKASGFLSFGLSPHICAGRHFATGEILALVALLLVRYDIRPIQGSWTEPKTNAKAVAASLPPAAEKFMVT
AVERPEYKGLEWRTTVTPGKGTYGLIIG*
>CYP660C2 Aspergillus flavus
97% to CYP660C2 Aspergillus oryzae
AFL2G_07402
MSDFTTIVGLSVVAILASLLFTQRPKLDPREPPLVSSTIPLVGHLISFLIYGIGYFATES
(2)
GKHSLPIFTMSILKQRVYIIASPDLL
HSVRQNRSTMSFNPLFTAMAQRAGGIQKPGLQLLREEELGGQGLAKKTVEVMRPALLGDKLDHLNEQMIHVLKHIVDQVA
SSPTLSFDLYEWCSDTLTVASTDAIYGPLNPYKSEAIRKAFW
DFESNLSLLLVDTLPWLTCRKAWKG
RERLVQAFIQFYQADGHISASSLAYSRWKAQQEAGASLEDIARLEILTGIGILSNTVPS
CFWLLFDILSRPELLSAIQDEIHQNALSIDSTGTHTLDLADIRGKCPTLLSSFQETLRTRSNSGQVRVIYQDTLLNDRWL
LKAGSTLLIPAPSINKNNSTWGSDAGDFDSQRFTKIAHQTHKKSKASGFLSFGLSPHICAGRHFATGEILALVALLLVRY
DIRPIQGSWTEPKTNAKAVAASLPPAAEKFMVTAVERPEYKGLEWRTTVTPGKGTYGLIIG*
>CYP660D1
estExt_fgenesh1_pm.C_chr_10897|Mycgr3 Mycosphaerella
graminicola
42% to 660A1 A. nidulans
44% to CYP660A2
MIASAISPTAAAVVALVIFFIVLVARGQPDRREPPHLTPRVPLVGHALGILCYGVPYYAKIAHQTSAPIFTLDLLVNRLY
VVNSARMVAAVQKSHKIIAFDPFLTAAANRMAGINGPGLRLLQETQAGGKGVNQEVLHAMIPTMLGSGLDQMNRTMLRKL
GPLLDDMIKDAPKTLDLHQWCQRTITTASSEAIWGSKNPFRSEKVREDFWYFESHLSILLAKIFPSVLARKAYLARETVV
KAMLEFAKSGGYDDEACSELAIARRNTQVKAGASDHDIARLETALNIGVLSNTVPSTFWTLFDIYSRPQLLQQVRSEIEE
NAVVVDPMTNVHSIDLGAIRGSCPIFVSAFQESLRVHSNGAPTRMVYEDVVLDGSYLLKAGSVLQMSAPSINSEQRHWGQ
QAADYNPLHFQKDAADVSANKPRASSFMSFGASPNICPGRHFAAAEILSVAAMLLMRVDMIPVKGYWWTPRLNAWAIAAS
MTPPIEEYPVKIVPRKEVQGIEWDFVVSGKKDRFELITG*
>CYP660E1 Coccidioides immitis
41% to CYP660B1, 38% to CYP660C1, 38% to
CYP660A2, 36% to 660D1
CIMG_02364.2
MEQFYLHLLVLLVLSILLRFLIAPGHAPEEPPLVSSRIPFIGHLIGLARYGNRYYVRLR
(2)
AQSQLPAITINIFRQKIYLIYSPGLLAAAQRHAKYISFEPFAALAIRRAAGIKGNGPIVSSSSEKGRSSFDKQMK
DAVHSVLLGEAMVGITRASVAAIKKSVDDLRSTEVDLLTWCRHVLTMATTDSIYGPMNPYRNREAEAAIWEFDSGLGKLT
LNFAQRFIAREAYQAREKLVKRLLEYFEKCGYINASSFVQRRLEVERKAGATLEDIARLETLMVLPLLSNSAPSTFWVLF
DIFSRLDLLEEIRKEIVQNALQFKPCDDSMGKPKQMCTLNMNNIRDKCPLLVATWQETLRLRANTASVRFVSKDTKLNDT
YLLKANSIVQTPANVLNVDPNIWGPDAHLYNPRRFLDTRASPGAGGDRKRDRKWNGFMTFGASPWTCPGRHFATAQILAL
VSLLVMKFDISPVAGDWVSPRINHRSMALAISIPAEGLMVNVVTRKEVKGIDWEFQMMEGKA
>CYP661A1 Aspergillus nidulans AN2607.1 30%
to CYP56A1 547 clan = 56 clan?
MHPTLLYTCTFFITVTALLWRYFRVPSTIPSNIPRIPIWVNFYAWYHDLS
VIELYDAFYRKIMEEHGAVVVWFTGAWCILVTKPEYLVEIFRNEDTYPKV
GVNVRGKGSLMGIFAGENIINSSKPTWATLTKVMKPGFLKSFDAQAIHAK
AKKVPERLLQAQSEVGKGKGVPATQWMEKYAQDVMGLCLFNFDLQALDEP
RVPYAPLLGQIIPTIFSRWAFYFPTLDIPGRYFLSRKATLDNIAKFDSLL
NEIVESTLNADAEKQPKVVSHMLKRALDNGQLTPELYRYNLRMSFMFGHD
TTAIFMGLTMYVLGNNTVLQDRLRTEVLQSTGKTIHQLPYLTSLLYEVLR
LYPPVTEVLNHTVSRPTALGGKVTIHPGTWLGWNAYGVHTNPAIWGPDAL
EVRPERWGDTVKDIQASFRLQSTKGNYIPFSLHARKCLGQSLVLTEVKLL
MFEMVRQLKWVVDPTYKLNLGGVTFTMLLGLRLIVEELELDSRDTVADEK
SQMHT*
>CYP661B1 Aspergillus fumigatus
XM_742987
38% to CYP661A1
shortened at N-term
MILYYLASIPLAIICYLAWYLHVPWDLPSLPRIPFYVSILGLWSSMGQDEIYERWLRKP
LEAHGAVLIWFAGRWSILVTRPDLLTDMFRNEDLYAKAGSQKKIPWSVIATLVGDNII
NSHGDTWKLYTGIMKPGLQKKNFDTAPLLLKSRRFVDEILAEQNSAGRGTGILVNTFV
QQWAVDVMGMSFLDLDLQSLEKPHGTVRLEAIQSVIKLMLFRPLFFNFPDLDQFAWLI
KSRQRAYEIMHEFGDTLMATVLGRIDSDREKGIKPAEEMVVHMLVDAYRDGRLTEKQF
KDNLKIVFLTAHENAQQLVNSMFWEIGKNNEVQTRLRAEILSTNTTTPTSEVVNALPY
LTAVVYELLRLYPPVSQLINRVTVRPAMLGNEIPIPAGTFVGWNAYGVHVNPAIWGPD
ANEFKPERWGRTVGEMHARFRRETVRGTYIPFNAHSRKCLGQGFVLLQMKILLFEVLR
RIEWTVDPGYRLKMTPVSYFLESGRKSTDA
>CYP661B1 Neosartorya fischeri
98% to CYP661B1 Aspergillus fumigatus =
ortholog
NFIA_039460
MILYYLASIPLTIILYLAWYLHVPWDLPSLPRIPFYVSILGLWSSMGQDEIYERWLRKPLEAHGAVLIWFAGRWSILVTR
PDLLTDMFRNEDLYAKAGSQKKIPWSVIATLVGDNIINSHGDTWKLYTGIMKPGLQKKNFDTAPLLLKSRRFVDEILAEQ
DSAGRGTGILVNTYVQQWAVDVMGTSFLDLDLQSLEKPHGAVRLEAIQSVIKLMLFRPLFFNFPDLDQFAWLIKSRQRAY
EIMHEFGDTLMATVLGRIDSDREKGIKPAEEMVVHMLVDAYRDGRLTEKQFKDNLKIVFLTAHENAQQLVNSVFWEIGKN
TEVQTRLRAEILSTNTTTPTSEVVNALPYLTAVVYELLRLYPPVSQLINRVTVRPAMLGNEIPIPAGTFVGWNAYGVHVN
PAIWGPDANEFKPERWGRTVGEMHARFRRETVRGTYIPFNAHSRKCLGQGFVLLQMKILLFEVLRRIEWTVDPGYQLKMT
PGGILAPLGCRVILSEVKEADKAEQRG*
>CYP661B2 Aspergillus clavatus NRRL 1
AAKD02000007.1 ctg02_1099423829543, whole genome
ACLA_002540
gc boundary After GKNT?
82% to CYP661B1
575568
MSLFYIFAVPLSLIILYLAWYLHVPWNLPRLPRIPFYVSILGLWSDMGQDEIYER 575732
575733 WLRAPLEKHGAVLIWFAGRWSILVTRPDLLTDMFRNEDLYAKAGSQKKIPWSVIATLVGD 575912
575913
NIINSHGDTWKLYTSIMKPGLQKKTFDSRPLLVKSRRFVDKILEDQATAGK-QGILVNAY 576089
576090
VQKWAVDVMGVSFLDMDLQ (0)
576146
576245
SLEKPHGAVRLESIQSVIKMTLFRPLFFNFPDLDQFAWLLSSRKRAYEIMHEFGDTLAD 576421
576422
KVLAQMDDATAKGQKPEEEQVVHMLVAAYRDGRLTQKQFKDNLKIVFLTAHENAQQLVNS 576601
576602
MFWEIGKNT (0) 576628
576739
EVQTRLRAEILATGTSNPTADIVNPLPYLTSVIYELMRLYPPVSQLINRVTTAPAMLGGQ 576918
576919
IPIPARTFVGWNSYGVHVNPQVWGADAQEFVPERWGSTVSEMHARFRRETVRGTYIPFNA 577098
577099
HSRKCLGQAFVLLQMKILMFELLRRVEWRVDPGYKLKMTPVS 577224
SHSSFCFVFFYYVACEV*
577278
>CYP661C1 Histoplasma capsulatum G217B
47% to CYP661B1
HCB03363.1
MALLACVGAAAVLFAITAWWYLRVPSHMPKNIPTVPFYVSSIAHFVDLGQDKIYDLWLREPLEKYGAVKFWVSSQWTVLL
GKPEYINDLLRNEQVFPKAGNHKRIPFSVIGTFLGNNIISAEGETWKLYTSIMKAGIQRRITDTSKLLGRSRQLVRGILQ
SQQAATANFGIDLESLVQMYAIYVVGEHFFQTDFQRLECNEATRLAKYQTAIRGNVFSPLYFSFPILDKYPYIFQSRKRA
FRIVKEYEDLLYEIVRVPRPRETPEDPMNQYERQVIDDLRDALDCRKITEVQFRANVKIIFVAGHEDVQHLLNSAFYEMG
AKTDIQQKLRLEVLNTGSIDPTPEIVDSLPYLAAIVFELLRLYPPLQQIINRKASETAVLGDEIVISPNTLIGWTAIGAH
TNKSVWGGDAREFDPERWGTTVDTIRAKFRRENARGAYIPFNAHARKCLGQGFALLQIKIALFELVRNVEWVLDPGSKMK
LARVSNYKISKAASPHRITINQSCVTGFIEAYRL
>CYP662A1 Aspergillus nidulans AN9210.1 33%
to 59B1 59 clan
revised 7/19/07
MLALLLVLVALTSYFLVRMRQQRGMFRNLPGPPHHAIWGHFLIMRDIASS
LPPDATPQLFAHLMRQRYGLGDFFYLDLWPLAPPQLVIAHPELATQIVHK
MNLPKESAVMQKWTGPILGEKSMVSANGHDWFIARKSFTPGFQPRKLQQH
IPHIVDETQAFADILREHFHMNDIFKMEDLVARMIFNISAGVILGIKCNA
QRDDDEFLELFRKQAALAPQDFWSRYLYDVSPRRYYRKWSNGRALDRYVG
RLVDQRVVSGPAANPDQKTKYYAIDDAIATSRTLNKNIPHTSSLDKYTRD
MLITSVKTLIFAGHDTSASTLCYTFAAISKHPQVLNTLRKEHNALFGTDP
SAAADLLRDDPNLVNNLPYTLAVIKEALRLWPPTGISLRRGQPDQTLFAE
GKEWPTYPFAVLVNNCATMRREDLFKDAERFYPERHLVNDPTDPYFVPRD
AWRPFEKGPRMCLGQTLALMQLKIALVMTVRTFDFEIVYEEGTFMYQVLD
VTAKPSLGLPTRVKLVE*
>CYP662A2 Neosartorya fischeri NRRL 181
89% to CYP662A1 Aspergillus nidulans
NZ_AAKE03000038.1, NFIA_044230
Note: this seq does not have an ortholog in A.
fumigatus
MLALLLVLVALASYFLVRLRQQRSMFK
NLPGPPHHAIWGHFLVMREIASTLPPDATPQLFAHLMRQRYGLGDFFYLDLWPLAPPQLV
IAHPELATQIVHKMNLPKESAVMQKWTGPILGEKSMVSANGHDWFIARKSFTPGFQPRKL
LQHVPNIVDEALAFADVLREHALKDDIFKMEDLGARMIFNISAWVIL
(2)
GIKCNAQRGDDEFLELFRKQAALAPQDFWSRYLYDVSPRRHYQKWSNGR
ALDRYVGRLVDKRVVSGPTAVPSEKARYYAIDDAIATSRTLNKSIPPTTALDKYTRD
116369
MLIASVKTLIFAGHDTSASTLC (0)
116479
YTYAALSKHPQVLHTLREEHTTLFGTDPSAAANLLRNDPSLVNNLPYTLAVIKEALRLWP 116658
116659
PTGVSLRRGQPDQTLLADGKEWPTYPFAVLVNNCATMRREDLFKDAERFYPERHLVTDPS 116838
116839
DPYFVPAKAWRPFEKGPRMCLGQTLALMQLKIALVMTVRTFDFEIVYKDGTFMYQVLDVT 117018
117019 AKPSLGLPTRVRLTE* 117066
>CYP662A2 Aspergillus terreus NIH2624
AAJN01000191.1
90% to CYP662A2 Neosartorya fischeri =
ortholog
ATEG_07945.1
MLALFLIPVALV
267630
SYFLVRLRQQRAMFKNLPGPPHHAIWGHFLIMRDIASTLPPDATPQLFAHLMRQRYGLGD 267451
267450
FFYLDLWPLAPPQLVIAHPELATQIVHRMNLPKESAVMQKWTGPILGEKSMVSANGHDWF 267271
267270
IARKSFTPGFQPRKLLQHVPNIVDEAVAFAGVLREHAQRNDIFRMEDLGARMIFNISARVIL () 267085
267032
GIECNAQRDDDEFLDLFRRQAALAPQDFWSRYLYDVNPRRYYQKWNNGRALDRYVGQLVD 266853
266852
QRVVSGPTSIPSDKAKYYAIDDAIATSRILNKTIPPSTSMDKDTRDMLIASVKTLIFAGH 266673
266672
DTSASTLC ()
266602
YTYAALSKHPQVLHTLREEHKALFGAEPSAAANTLRSDPSLVNNLPYTLAVIKEALRLWP 266423
266422
PTGVSLRRGQPDQSILADGKEWPTYPFAVLVNNCATMRREDLFKDAERFYPERHLVTDPA 266243
266242
DPYFVPRDAWRPFEKGPRMCLGQTLALIQLKIALVMTVRTFDFEIVYEEGTFMYQVLDVT 266063
266062
AKPSQGLPTRVRWIE* 266015
>CYP662A3 Aspergillus terreus
52% to CYP666A2
ATEG_09350.1 this model is a fusion protein,
revised
MFQSFGIALWGFLALYPIHVTLEFFKNRRLAQQIGLPYMVFPFSEHSVFYLGFVETRWYRYLVDHCLPAWLADLVHNSSF
KYRWRVKDRITKLYGPVYTIVTPWSVTCHVSEANVVTQVCMARRSFPKPVKNYEGFAIYGPSVLTSEGNQWARYRRYTSA
TFNEKNNALVWQESIRQGIQMTNYWEEKHASDSPHTLFSLPDVRDDIVKFTLNIICSAGFGVTLPFKPAYKATTGDAEGL
FQDAVMPPQGYSFTFPSVMEYISTSMSTVFFANGIWPKWIPRRMAPFFKTDFMAYDDLGKYLRALLDNAEVRENPSSHNL
LEGLVRARRENSELGSTHRVDGLSDEEIFGNLYIFMIAGHETTATTLRFALVLLAMHQDVQDHLYDEIQEVTMGEPANPT
GWDYERTFPKLVAPLCIMLETLRLYPPVSSLPKWTDTSSASISYRDQAYQIPPATYLCLDANALHYDEMYWGPNASEFDP
SRWDKRNIDSFLAKNDGLDGLSGPGLEHDTIHRPVRGAFLPFSDGLRACVGKKFAQVEFVAALVIIFRNYRVTLQKHADE
SESEMRCRVQQALEQSSNAQTLTIGENVPLVFSRREA*
>CYP663A1 Aspergillus nidulans AN7399.1 35%
to 546B1 64 clan
MTADIKTLLLAALGAVAVAWLAQSFGKRSSLPLPPGPKPALLIGNIHQLP
KSLQWLHLYHLSKEYGPIMHFSMAGQPLIILSTHQVAHDLLNRRSGRYSD
RPRMVMAGELVTKNMHMLLRPYDERYKLHQRMEAPLLVLRSASNYRPLQD
LESQQLLFDVLGEWDKFGEKGVDFHHHFERAMASTIYCLNYGYRLQTGYE
KELMDGKKVQAEFARTGQVGAYLVDSFPSLNYLPKFLAPWKKEGEGLYEL
ERQLHVGNLKKGLSNRGWNFTKYMKDSPEAVTMPEEELAFDLGILADAGL
DTSTVALDWFIVAWITSGSTWVKKAQQLLDEVVGKDRMPTFEDRPKLAYI
DAIASETLRWRPVVVSGVPHFTKVQDEYMGYHIPANSTVLPNAFAISHDE
SIFGEDVDSFIPERWLAEDPPSEPSIDACGFNTSALKDLPHIGFGWGRRI
CTGRFIARNQLFIQMARMLWAFDVDAGVVDEKTGRRHNVDDMDCTEGFVT
LPKPFRAVMRPRGEWVRQRILERGTTHGLDHAKILQNAKLGRS*
>CYP663A2 Nectria haematococca
e_gw1.12.597.1
Necha1/scaffold_12:54695-56385
80% to 663A1 AN7399.1
MLLQDRRSLGLAVVGAFVAWLLKRYLSGRGKGPLPPGPKPAPVIGNIHQLPKSLQWLHLYRWSKEYGPIM
HLSMGGQPLIILSTHQAAHDLLNRRSAQYSHRPRMVMAGDLVTKNMHMLLRPYDERYKLHQRMEAPLLTL
RSASTYRPLQDIESRQLLFDVLGESNQAGDKGVDFHHHHERAMASFIYCMNYGYRLKTGYEQELMDGKKV
QAEFARTGQVGAYIVDSFPSLNYLPKFLAPWKKEAEELYELERQLHVGNLKKGLNNRGWNFSKYMEASPE
ATDMPTEELAFDLGILADAGLDTSTVALDWFIVAWITCGERWVGKAQKVLDEVVGRDRMPTFEDRPKLAYIDAI
(1)
ASETLRWRPVVVGGVPHFTKKEDTYMGYYIPANSIVLGNAYAITRDESVFGEDVDAFLPERWLADD
ANTKEPNIDACGFNTTALKDLPHTGFGFGRRVCTGRIIARNQLFIQMARMLWAFNVEAGINEATGEKHKV
DDMDCTEGFVTLPKPFKTVYHPRGQWVRDTIAESGTTHGLDHAAILDGAKKDRAKA*
>CYP663B1 Aspergillus niger
e_gw1.10.193.1|Aspni1
43% to CYP663A1
MPTILLTLLALLTLRLLYEYKRDRNLPPGPRRLPLIGNLHQAPQTLPWRVFDQWSKTYGPIMSAQFGRQTLVLITSPTIA
RDLLDKRGSIYADRPDLVMANNITKGLHMLIRQYDDWLRLHQRLDAPLLSPRASNTYHPIQDLESKQLMFDLLRSNDFDA
HFERYSGSLMFALAYGFRLLSPKGQELRDMRTIQGNFTYAARVGTWIVDAIPVLNYLPAVVATWKRLAEKLFKLEASVHT
RHLEKGLNSEPWNWSKEFAASKHAEGMPRLDLAYNLGILVDAGFETTWAVMKIFVLAIRSDSRFVAVARKELDEVVGEDR
MPTFEDQEKLVYIQAVVDETLRWRSMAPGGIPHATRKEDTYMGYRIPKGATVIPLFWSMSLTDEPWDDPLEFRPERWFEA
TEKEEGRFRNFFGYGRRICTGRHIARNSLFLLMARILWAFDIQAPLGDDGKPVPVDDMAFDSAFVSTPEPFEALFVPRSE
KTKEIVEREWNEMEKDMAVLMGQVRESQR
>CYP663B2 Aspergillus clavatus
60% to 663B1
ACLA_078190
MISIYILVGLVLLRLLYEYHRDRNLPPGPRRLPFIGNIHQVPQSHPWRVFDAWSKRY
GPLMRAQFGRQTLILIADTRIAR
ALLDKRGAVYSDRPRMVMAGENVTRGMHMLLRPYDARYRLHQRMEAPVLSPRASATYTPLQELESTQLLTDLLRSNNFTI
HIQRYTASLVYGLAYGFRLPTGAEPELLTLRRILHNFGHVARVGTWLVDAIPLLNYLPAWLAPWKRSANALFELEADLHR
RNMDTALHNKPWNWTKELARSPHATPMSPLEFAYDLGNLTTAGYDTTASAMRVFVLAAVTAPAFIAAAQRELDTIVGPDR
LPSFADKENLP YIAAVVEETLRWRSIAPGGPPHATSAEDEYMGYRIPKGATVMPLHWSMSMDAGDFPDPLAFQPERWL
AAPQQQQQQGGDGKGNEHE
RFTSFFGWGRRMCAGRHIARNSLYILIARLLWAFEIRAAEGPDGRPKHVDDMAFDDGLVSSPE
PFEAVFVPRSEAVRRVVEGEWAGLEKDMEVVMGGIRERQRAIGLEVRV*
>CYP663B3P Aspergillus oryzae
Supercontig 6: 3781646-3782486 (+) strand
MAYDNLLLHWWKRNQSINESPPLPLSCIAGCVSLAHVLTQKKLIQDTKM
EFGILNSFLALLILRVIYEYYRDRRLPPGPRR
LPLIGNIHQVPQVLPWRTFHQWSKKY
(large deletion of about 274 aa)
IRVVVEESLRWRSIVPGGVPHAARKDDTYMSYHI
PKGATIVPLHWSMSLDEQHFDNPLEFRPERWLAEPDDDRFTNFFGHGRRICPGRHIARNS
LFILVARILWGFEVRPPTGPDYQPKIVEDMDFGSAFVSVPAPFEAIFQPRSENARRVIES
EWESTEKDIIALMDSIKEK
>CYP663B3P Aspergillus flavus
95% to CYP663B3P Aspergillus oryzae
AFL2G_01674
MAYHYLLLHWWKRNQSINEPPPLPLSRIAGCVSLAHVLTQKKLIQDTKMEFGILNSFFALLILRVIYEYYRDRRLPPGPR
RLPLIGNIHQVPQVLPWRTFHQWSKKY
(large deletion of about 274 aa)
IRAVVEEGLRWRSIVPGGVPHAARKDDTYMSYHIPKGATIVPLHWSMSLDEQH
FDNPLEFRPERWLAEPDDDQFTNFFGYGRRICPGRHIARNSLFILVARILWGFEVRPPTGPDYQPKTVEDMDFGSAFVSV
PAPFEAIFQPRSENARRVIESEWESTEKDINTLMDSIKEK
>CYP663B4 Aspergillus terreus
64% to CYP663B2
ATEG_07324.1
MAITILTSILGIFLLRLIYEYQRDRKLPPGPRRLPFIGNIHQAPQILPWRTFHEWSKKYGPIMSVQFGRQTIILIADATI
ARELLDKRGSIYSDRPRMVMANENLTKGMHLLLRRYDERYRLHQRMEAPVLSPRASSTYYPIQDLESKQLLYDFLSSNNF
FKHFERYSASLVYTLTYGFRLETGEEQEMKSAREVMHNFGLAARPGTWIVDAIPALNTLPMCISPWKQTAEKFFQIEANQ
HMRNMTVAKENKVWNWTKEFVVSKQAEDMSPLELAYDMGILADAGLETTSGVMQTFTLALLSYPGFIKTAQEELDRVVGP
DRLPTMSDRENLPYMTAVVEETLRWRSMAPGGVPHATLKEDTFMGYRIPKGTMVMALHWSMSFDERHFENPLEFHPERWI
GRNPDDGCFTNFFGYGRRVCTGRHIARNSLFLLMSRILWAYNVQPGTGPDGKPKKVDDMAYGSGFVSIPLPIRRDL*
>CYP663C1 Mycosphaerella fijiensis
50% to CYP663B4 Aspergillus terreus
gw1.8.660.1 revised N-term
MIANIIYSITLLILVRILYEYTIRDRK
LPPGPRRLPLIGNLHQVPAAGQLPWLVYHQWAKEYGPIYSLQLGGTTFIVISSGEIARDLLDRRGSRYSDRLESVMAGEI
LTKGNHILLRPYDGTYRLHQKMEAPVLNSKTSPLYAPVHELESLQLLKDLLSTNDSHSFAEHLERYSISIIYSLAYSLRV
PDFTHPDVATIHETQAHMLDCLVPGKWLVEVIPAMKYLPRCLAPWRVIAENYHLIESNLHLKHMDYGLSTQSWNWTKEFT
SSPQGTDMERLEMAYDLGILADAGMDTTAAILQTFVFAAVTQPSFLVSAQKELDSVIGQHRIPMLTDKAKLPYIMSIVNE
TFRWHTVVPVLTPHATKVEDESHGYRIPAGSCVLALQWSMNMDETSFPDPHTFSPDRWLDGLDAKKKKFHAFGYGRRICT
GRHIAENSAFLVIARLLWAFEIFPG*
>CYP664A1 Aspergillus nidulans AN9222.1 37%
to 530A1 66 clan
revised 7/18/07
MTMAALDVFNVPYSVPLLGSTVVILIGFIAIKALRVGSRPKGLPPG
PPTEFIWGNTKQIDLFYPQYQYRKWAQQYGPVYTVMLGDTAHVVVSGLRD
VRDIFIKQGASSQNRPPSRFQLLMRDGFFPGLNNGEKWRQSRRMWQAVLN
NSAAKQYLPYQELETRQLLFDLLRAPTEWRDHIERYSNSVAMTMVNGRRI
IDAADPRVKETIQDLYDLAETGVRGAFLDSWPFLWKLPEWMFPVCRQARK
IAAKHREYIWRNYSDVAKRTSQGEVLPSVNHAIQEKLKQGWPGVSEIEGA
EIGHHLLTGTTDTTASTLINWVAAMCLHPEAQKKAQEEIDRVVGPNRLPT
DADAANLPYVQQVIQEAQRWITAVPLSLPRAANAPVHWGKYTIPEETGLI
MNSHALHNDPDIFPEPDKFKPERWEGKPNASSNGDAQLLFTFGAGRRVCP
GQHLAERSLFLVISHWLWGFDTLQATDDDKNKIPIDKDDLRPGFIVCLNP
FPAKITPRTAQHRELIERIWKEELEVSLDESQQWKATPEGIARLLERVGK*
>CYP664A2 Uncinocarpus reesii
58% to CYP664A1 Aspergillus nidulans
UREG_03024.1
MATIRRALPFSTATLGCVVLIAALSYLLYRLLGIGRRPAVLPPGPPTQAIWGNLRQCDSFFPHHQYTEWASKYGPVYTMM
QGGQPQVIVSGLAEAREIFVKQGARTQSRPPSRFKLLMRGGYFPSVMNGLKWQHARRMWHAVLNSSASSKYLPYQELESE
QLLLDMLNKPHCWYDHLERYTNSVGMTMVNGYRITSSDDPIVKETIEDLYELSRVGVRGNVLDLWPVLWKLPIYLLPICR
EARELAEKHKRFIWRNYTAVKESVKQGTTLPSFNRTIQERLQSGWRGVSEIEGAEIGQHLLSGATDTTVSVLTTFVAAIC
LFPGVQRKAQEGSERLPQYEDTASLPYIQQLILEAQRWITSVPLCLPRVANGTVRWGNYEISEGTGLIINAHAIHSDPGM
YPEPHIFQPERWEGKLDATRPDNQLLFTFGAGRRHCPGQHLAERSLFMVVSRWLWALDTSQAKDKDGNDIPINTKDLRPG
VINRLKPFQADIKPRSPERATLIRQVWRENCEYLLDQKHQWKLNPDINYKRVK
>CYP664A3 Coccidioides immitis
66% to CYP664A2
CIMG_02812.2
MALTHRVLPFSAGTLASVAVSAALGYLIYRLLRLGRRPAYLPPGPQTQAIWGNLKQ
(0)
CDPSFPQHQYADWALTHGPVYTVMQGDTPQIIVNRAAEARDVFVKQGAYTQNRPPFRSIMLLRDGY
FPSLMNGSKWQNARKMWQVVLSSSAIKNYIPYQELESEQLLLDTLNEPLLWYDHLERFANSVGMVMVNGYRITSSSDPIV
KETVEDLYDLSRVGFSGNMLDFWPFLERVVWTLPIYKVGRRMAKKHKDYIWKNYFGVKQRAEQGTRLPSFNRTIQERLQ
EGWTEVSELEGAEIGQHLLSGSTDTVVSTLTTCIAALCLFPDVQRKAQE
(1)
VVGPDRLPRGEDEINLPYIQQLLLE (2)
AQRWCPAMPLCVARVTSGPVSWGKYNFPENTGLTINTYAIHNDPELYPEPH
IFMPERWEGRIKAAHGENQLLFTFGAGRRFCPGKSLAEKSLFIAIARWLWAFNTSHATDEEGNKIPIDPKDLRPGNIVRI
KRFSADVQPRNPQRAGVIRRVWREKCDTLLDENHQWKTNPERIAESMKMECDI
>CYP665A1 Aspergillus nidulans AN2727.1 35%
to 530A2 66 clan
MGLSLGNDLWILLVSLLVAIVTSLVVALAPYTWASLRPKNFPPGPKPLPL
IGNLNLIPPSKAFLLFHQWTKKYGPIIGLKFGPTNVVVLNNWKDVQELLE
KRGHIYSSRPDNYIANELICKNHTHILFAPYGDGWKALRKAAQGLFTPRE
LAGVLPIQEAEATQTAFDLIRSPDRYYEHIQRYTTAVILASVFGQRGADF
NSPNVQALYDVQNRFTALLEPGAAPPVDGITFLRHIPEFLAPWKRRAKEI
RRDQRALYFRLYNATKERMAKGIRTGCFMEKLIDDQVKNGLDDEHTTYLG
GILMEAGSDTTSSTLLSFLLAVLENPGALKRVQEDVDRVVGTERSPTMND
LENLPYIEACMHEILRWRPVAAGGIPHMLTQTDTYKDYIFPAGTIFFANT
WAIHHDETEYSNPAIFNPDRWLDGNKYGTKDNNSTLDSTAQRKTSYGWGA
GRRICSGQKMAEASLKINIAKLVWAFDFERVKGEENVDISVDTGYEGGFL
VCPKKFPIKITPRSEGRAAVIEKEFEGLKGFYEKLAA*
>CYP666A1 Aspergillus nidulans AN1748.1
poor match 534clan
MLVFTIPLATALIYITHSAFSFLSNLYLVCKTCPSLPRVLFPVSEVNLLY
LALFESRWFNHIRRYWLPTSIADYIADAAFRGRWDVKDRLARKYGGFYLF
VAPGLISCHVGDAEVVSQVVKERKGFVKPVKHLEAFEMYGRNVLTSEGSE
WAYHHRYSASAFSDKNNGLVWQESAIQAQEMLAYWEKKFNASNGSDRFTV
PDVREDILKLSLNIICSAGFGVRLPYRPATSATAERDKDSAEDLFRDAAT
PASGYHFTFRGVMEYMNRSMMSVFIANGILPKWIPRMLVPFFKTDFAAHE
DLKKYLHALIEVTENSEHERHNLLGRLVAARREEQSVRCSGSGPGLSNAE
ILGNTYIFSLAGHETTATTMRFALPLLAIHQDVQDRLYKELEEALRDQPA
NPAEWEYSTVFPRLVTPLC (0?)
LETLRLYPPVVSIPKMTTTHMAEITYKGERHCLPPNVRVNLNANVLHY
SEAYWGPDADSFDPRRWDKRNAGSFLARNASARGLSGPGLESPNVHKPVR
GAFIPFSDGLRACMGRKFAQVEFIATLAVIFHRYRVTLVRVGQETEDDAR
KRVEKALRQSSTLITLALGGVVPLAFVRRTGVAAEDDA*
>CYP666A2 Aspergillus oryzae RIB40
AP007151.1 genomic DNA, SC005
50% to CYP666A1 Aspergillus nidulans
join(3144893..3145283,3145344..3145394,3145416..3146254,
3146318..3146493,3146532..3146865)
model wrong, frameshift at 3146521
3144893 MLGIILFSLFISYTAYLGLCFLRHWSLARKIGLPYVSFPISSHN
ILFLSLFETRFVPYVINTWLSPKLADFIYGSAFKTRWAARDRLHRRYGGVYMLITPSV
STCMVCDASVASQICMSRHGFPKPIKQY (1) 3145283
GALEMYGPNIVT (0)
3145445
SEGSQWAHLRRHTATPFNERNSALVWEETIRQTKEMVQYWEDEYSRSSSASEFILTDTRED
ILKFTLNIICSVGYGVKLPFRPGLENSTESAEGLFKDAITPLPGYHFTFRSAMEYLNK
HITSMFIANGLLPKGIPRSVLPFFKKDFDAFDDIGRYLRALVSTAETKETLSQNLIDG
LVRSKQKIDKDQGLDPELTEDEILGNLFVFTIAGHETTAVSLRFALVLLALNQDAQEY
LYEGIREATYDEPRNPVEWDYRRVYPKLVSPLCVM (0)
LETLRMYPPVSGIPRWTGDSAVN
ITYHNQPYLLPPHVYVNVNASGLHYSEEYWGPDAAV FDPKRWDKR 3146521
3146521 NTRSFLAKNKEGGLSGPGLEYDTIHK
PVRGSYIPFSDGFRSCIGKKFAQVEFVVAMAIIFREYRVMLAKSNERETEDDLRRRAE
KALGESTAFITLSMRDEVPLLFQKRCVSKA* 3146865
>CYP666A2 Aspergillus flavus
99% to CYP666A2 Aspergillus oryzae
51% to CYP666A1 Aspergillus
nidulans
AFL2G_01122
MLGIILFSLFISYTAYLGLCFLRHWSLARKIGLPYVSFPISSHNILFLSLFETRFVPYVINTWLSPKLADFIYGSAFKTR
WAARDRLHRRYGGVYMLITPSVSTCMVCDASVASQICMSRHGFPKPIKQY
GALEMYGPNIVTSEGSQWAHLRRHTATPFNERNSALVWEETIRQTKEMVQYWEDEYSRSSSASEFIL
TDTREDILKFTLNIICSVGYGVKLPFRPGLENSTESAEGLFKDAITPLPGYHFTFRSAMEYLNKHITSMFIANGLLPK
GIPRSVLPFFKKDFDAFDDIGRYLRALVSTAETKETLSQNLIDGLVRSKQKI
DKDQGLDPELTEDEILGNLFVFTIAGHETTAVSLRFALVLLALNQDAQEYLYEGIREATYDEPRNPVEWDYRRVYPKL
VSPLCVM (0)
LETLRMYPPVSGIPRWTGDSAVNITYHNQPYLLPPHVYVNVNASGLHYSEEYWGPDAAVFDPKRWDKQNTRSF
LAKNKEGGLSGPGLEYDTIHKPVRGSYIPFSDGFRSCIGKKFAQVEFVVAMAIIFREYRVMLAKSNERETEDDLRRRAEK
VLGESTAFITLSMRDEVPLLFQKRCVSKA*
>CYP666B1 Aspergillus fumigatus Af293
XM_741694.1 cytochrome P450 monooxygenase (Afu7g01450)
44% to 666A1, 48% to 666A2
gene model wrong, correct with genomic DNA from
AAHF01000015.1
revised at VM boundary 3/11/2009
MIWSSVLLGLAGLYAFDYFRRLFNNIR
82
LAQRTGLPYTVLPFAGNSLQVKILLSIRWLPYIINHWLPGWLADIINDETYDYRWTVKDR 261
262
RAKKLGKMYMVVTAENIVCHIADASLVTQICNARQSFPKPIWQY (1)
ELLNLYGPNLLT (0)
CEDQAWAHHRRHTAPTFNEKNSALVWEESIRQMTEMLHHWQVAGTSEKLHGFVVASTRGDLLK 543
544 FSLNVLCGAGFGVKLPFKQLPQESTNDPNDVFKDTEKPPEGFSFTFRSAVAYMNLRIMTV 723
724
VLATMVIPKWIPRALMPWLKSDFEAHRDLEAYLRKLISMGKAEKTADKPDNSQNLVQGLL 903
904
MSRNKEAASGSSKGIGLTDLEIIGNMHIFTIAGHETTATSLRFTLLLLALHQDVQDWL 1077
1078
YEGVLEAAHGEPKDVAQWDYHRMFPKLITPLCVM (0)
LEVLRLYPPVVTVPKSTSETPSPLTY
1257
1258
QGKQYVLPPRVNINLNTNCLHYSEQYWGPDVAIFYPQRWDARNQNSFLAKNASTQGLAGP 1437
1438
GLEFPTVHKPVRGAFIPFSDGFRACLGKKFAQVEFIAALSALSRNYKVELADDSPEGRND 1617
1618
AERVLRESTSVLTLSMREDVPIRFQRRKD*
1707
>CYP666B1 Neosartorya fischeri
93% to CYP666B1 Aspergillus fumigatus =
ortholog
NFIA_114140
MIWSSVLLGLAGLYAFDYFRRLFKNIRLAQRTGLPYTVLPFAGNSLQVKILLSIRWLPYIINHWLPDWLADIINDDTYDY
RWTVKDRRVKKLGKMYMVVTAENIVCHIADAHLVTQICNARQSFPKPIWQYGFLNLYGPNLLTCEDQGWAHHRRHTAPTF
NEKNSALVWEESIRQMTEMLHHWQIAGTSEKLHGFVVASTRGDLLKFSLNVLSGAGFGVKLPFKQLPQESSNDPNDVFKD
TAKPPEGFSFSFRSAVAYMNLRIMTVVLATMVIPKWIPRALIPWLKSDFEAHRDLEAYLRKLISIGKAEKTADSSQNLIQ
GLLLSRNKVAANGSSKGTGLTDLEIIGNMHIFTIAGHETTATSLRFTLLLLALHPDVQDWLYEGILEAAHGEPEDVAQWD
YHRMLPKLITPLCVMLEVLRLYPPVVTVPKSTSKTPSPLNYQGKQYLLPPRVNVNLNANCLHYSEQYWGPDVATFYPQRW
DARNQNSFLAKNAGAFIPFSDGFRACLGKKFAQVEFIAALSALSRDYKVELADDSPEGRKDAERVLRESTSVLTLSMRED
VPLRFRRRKD*
>CYP666B2 Aspergillus niger
fgenesh1_pg.C_scaffold_12000110|Aspni1
59% to CYP666B1
MIAYTLVLGFIGLVVFDYIWNLAQNIRKAQRTKLPYVASPYNVSIIFIILFGWLLPLLAEYCLPQWMGDLLYDNVGTYRW
TVRNRQVKRYGKVYILVNPRGVFCSVADASVVCQIVNARQDFPKPNNALVWEESIQQTQDMIAQWAEASPLDSTRGSGFT
VESTRDDIHKLTLNVLSGAGFGVKAPFKLLPQESLKNPEDIFRDSPTPPTGFDFTFRSVVAYMNLHIPTMALANNMLPKW
VPRPLVPFFKQDFAAHRDLDKYLQRLITTTESRLSGEENPSNLIEGMLISRKPGDAKDAGLSDREIISNMHLFTIAGHET
TATTLRFALVLLALHQNVQDWVHNGIAEATKDKLPNIEDWNYDDAFPKFVTPLCVMLETMRLYPPVITIPKFTGDSPSVI
HYDGKDYVLEPGTYINLNTNGLHYSEEYWGDDATLFQPQRWDARNKGSFLARNTDLPGLAGPGLEYPTIHKPVRGAYIPF
SDGFRACLGKKFSQVEFVAALTTVLRQYRIELADSSEKGRINAERVLNQSTSIITLAMGEEVPLLFRRR*
>CYP666B3 Aspergillus clavatus
71% to CYP666B1
ACLA_066120
MIISSLILGLLGLYAVDYFRRLLKNIRLARRTKLPYIVLPVSGSASIPLKILCGFKWFADAINYHLPGWLADIVNDATYD
FRWTVKDRRAKELGNMYLIVTAEKIDCNVTDASVVTQICNARQSFPKPIWQYKILDLYGPNLVTCEDQAWAHHRRHTAPP
FNEKNNALVWQESIRQTTEMIDHWQRLHSPDDKQGFVVANTRDDFLNLTLNVLSGAGFGVRLPFKPSLQNPIDGPDDIFQ
DTAIPPKGFGFTFRSVMAYMNVNIPTVVLANIVLPKWIPRALVPWLKPDFEAHRDLKAYLQRLIATAAPEKTANSSPNLI
KGLLLSRNQDAGSSTTKDSGLTDLEIIGNMHIFTIAGHETTATSLRFAFLLLALHQDVQDWLYESILVAAQGEPADVAKW
DYSRMFPQLIAPLCIML ETMRLYPPVVTVPKSTSENPYPLEYHGKEYILPPFTNINLNSSSLHYLEEYWGPDAAQFYPQR
WDARNQESFLAKNTLTPGLAGPGLEYATVHKPTRGAFIPFSDGFRACLGKKFAQVEFVVALAVLFRDYKVELADDGPGAR
LDAERVLRESVAVLTLAMRENIPLRFRRRSHCDGL*
>CYP666B4 Aspergillus terreus
59% to CYP666B1
ATEG_07596.1
MNNFRWRIKNRQVKRYGGVYLVVTSKTVTCCVADAAVVSQIVNARNEFPKPIWQY (1)
KVIELYGPNLVT (0)
CEDKEWAHHRRHTATTFN
ERNNELVWKESIRQATEMLHYWRQTASPRPDTLALNDISEDIVQFSLNVISGAGFGVQIP
FKPSLSRANSPNDADIFQDTACPPPGFDFTFRSVVAYTDVKIRTVVFANLMLPRWLRRPL
APFLRRAFAAHRDLENYMKRLIETGSASFAGAHGTKETASNLIHGMLASRADAADKAKGL
SDREIISNMHIFTLAGHGTTETSLKYAFVLLALSPRVQEWLRQGILDAVGNEPADPAQWD
YAAVFPKLVTPLCVM (0)
LETMRLYPPVVTVPKWTGASPSRIHYRGRDVVLDPGVSINLNMNGLHYSEEYWGVDADTF
DPARWDARNSGSFLAQYANTPGLVAPGLEYPTVHRPVRGAYIPFSDGFRACLGKKFAQVE
FVAALAVVFRVYRVRLADESDAGRRQAERALQESVSVVTLGMVEGVPLVFERV*
>CYP667A1 Aspergillus nidulans AN3272.1 29%
to 589A1, 534 clan?
MLSLPSSVFTILVGLFLYKIIRLAHNVRLARKTSLPYIITPLLETEVVAL
LLNPLLRYLYRDYLDRGKGWPRWCRFFVKDWAWEDKRQAHDELGDVFLCV
SPEGIICYSADATMGWDVMNRRNTFTKPRDKYKVLEPYGMNVATAEGKTY
QFHVRITAPPFGDLSGVNNLVWRETVHQTKRLTEAWAESPPTEIQKDVNA
LTLAIISLAGFGKRLEWSKNGEKEGVPAGYQLSFLHALQDTLHYMVPILL
FPRWVLRVILHKAALAHAQLDRYLREIIRDQKAKLSADINHSDKQSRGNL
LTAVVRASMVFDSEQSSKESSRSSGERKQGFTEDETMGNLFIYLLAGYET
TANAIIYGLAVLALHQDIQDQVIEEIDRAHARAQSANRSELTYEDDFEFL
EYTYGFMYETFRLFPGVTLITKMIHQPERIITDGPDGSPKSYDLPAGTRV
YLNAPVVHYHPKYWPEPYKLDPNRWRSSQGEKHVVASDRTRQMKGTLLTF
SDGSRACLGRKFAQAEYVAFFATLLRQYRVRLAPGSDPAVVERDLFGKSA
GTITLAPLANVRLHIQPR*
>CYP667A2 Aspergillus clavatus NRRL 1
AAKD02000032.1
91% to 667A1, one in frame stop codon
ACLA_063860
178399
MLPLLSSAFTILAALFLYKVIRLAHNVRLARKTGLPYTITPLLETEVLALLFNPLLRYLY 178220
178219
RGYLDRGKGWPRWCRFFVKDWAWEDKRQAHDDLGDLFLCVSPEGIICYSADATMGRDVLS 178040
178039
RRNTFTKPRDKY (1) 178004
177920
KILEPYGMNVATAEGKTYQFHVRITAPPFGDLSGVNSLVWRETIHQTKRLTEAWAKSPPI 177741
177740
EIQKDVNALTLAIISLAGFGRRLEWSKDGENEGIPAGYQLSFLHALQDTLHFMVPILLFP 177561
177560
RWVLIIILNKAALAHAQLDRYLRDIIRDQRAKLSADINHADKESRGNLLTAVVRASMVFD 177381
177380
SEPPSAKSSRLSGERRQGFTEDETMGNIFIYLLA (1)
177209
GYETTANAIIYGLAVLALHQDIQDQVIEEIDSAHARAQSANRSELTYEDDFEFLEYTYGFMYE 177021
177020
TFRLFPGVTLITKMIHQSERIITQGPDGTPKSYDLPAGTRVYLNAPAVHYHPKY*PEPYK 176841
176840
LDPNRWRSSQGEKHVVASDKTRQMKGTLLTFSDGSRACLGRKFAQAEYVAFFATLLRQYR 176661
176660
VSLAPGSDPAVVERDLFGKSAGTITLAPLGNVRLRIQPR* 176541
>CYP667A3 Penicillium citrinum
BD294641 PAT 04-NOV-2005
DNAs
related to the biosynthesis of ML-236B (compactin)
MAFGPYVAYGALALAAYKIAKLFFFVFQARKTGLPHVLTPFLETEVIAFLLTPILRTVYH
AHLDKETGWPRWCRFIVKDWSWEDKRRAHEEYGDVFLVVSPEGIICYSADAAMGWDVMNR
RKDFTKPRDKYKILEPYGPNVATAEGGTYRFHVRVTASSFNDQSGVNDLVMSETIHQTQQ
LCKLWVKGAAPELQAGVNSLTLAVISLAGFGQRLDVGGKSKKGIKVPQEAKMSFLHAISD
TTKYMVSILLLPGWLLKLTPLRKAHFAHQALDYYLRQLIRDKRKQLVQDINHQDGTSNRG
NLLTAVLRASLTDGDLAKAGGARKDAFTEEETMGNLFIYLLAGYETTANAIMYGLFLLAL
HPEIQEKVICEVDRVWAEANASGRESLSYQHDFDKFYESFRLFPGVTLITKIANGDQPVH
VSNSSGVTTTHILSSGIRVYLSAPGVHYHPRYWPEPNKINPQRWMQNFSNESSGKRVVAA
DRSRQMKGTLLTFSDGARACLGRRFAQAEYIAFFAAFLKGHRVKIRPDHDRQTVWRDIYL
KSAGQITLAPLDTTGLVIERR
>CYP668A1X # Aspergillus nidulans AN1300.1 poor match
53 clan similar to 548A3
name changed to CYP548G2P
>CYP669A1P Aspergillus nidulans AN0008.1
poor match 53 clan
since this is a probable pseudogene and it
matches very well
after MDGPSN, the N-terminal my not be real
WKGHPFTPVVNIVPAFISSLLAFSLSTSQFAKTYRPFKNAPSSLVNHT
VKFAGSSAVHGSHRVSILSSA
SSGSVSGSAPNLLVNAV*TMPGLSA
AAKTDGFSAAIHAMNLVSANLDVMYPDSPG (2)
MDGPSNRNIRSDWYDLLHPQVSSIFTRDRILHQKRRQLWTKALSST(1)
SIQLYTRRILSKIYALES
14773
LIATAADEGKPVLINEVMYWFAFDSVGDFAFSEDFGMLRNEGWHDVIWMFRSALALLGPF 14594
14593
SPAIWMPRLAFSYIPGLWRVKWWFNMLEFCDRCMEQRMK (0)
14416
KTPKESNIASWFLKDHKVHRQNAWLSGDTATLVVAGR
DTNAPTLVHLFYFLARYPEHTEKIW*
ELVSVNAEDPVALAKLPHLNGVINESMRLLPAVL
14054
14053
TFGSRTTQPEGLTVEGTFIPGGVKISAPRYTIGR
(1)13952
13871
LKSAFAETHEFIPEWWYSRPDLVKDRRAFAPFGV (1)
GSTSCVGK 13692
13691
SLALAQIRLVTAALVSKYKFQFTPGMGSGEAVEGEMREQLTAQPGHCYLNFIRHVGQE* 13515
>CYP669A2P Talaromyces stipitatus ATCC 10500
ABAS01000028.1
frameshift after NIFVY, stop in N-term, pseudogene or seq errors?
62% to CYP669A1P from MDGPGNNN
TO THE END
257826 MFRKEVFAIALGILAHRIVFIH
GE*HLRAPSVVVIHLVLGLLIFTREVTLKHDRYNELLLHAMILPSCYLTSLFLSIAMYGL
FFHRLRHFPGPRLVALTKLWHVWKCRDSRGHLVLEEWHQQYGTFVRT
(1)
GPEEITIFHPAAHEAMDG
257309 PGNNNVRLDWYDLLYPHISSIFTRDRDLHNARRKMWEHALSRT
(1) 257181
ALLYGYYQRILRKVKTPESLVADQYYRPININELMYWFAFDSMGDFAFSEDIGMMRNKAWQKNIFVY
RSATALLGSLSPAIWIARLGFAFIPGLWRVRDWFQMLAFCDQCMEQRMKKEVENRDIASW
FIDDYVLCEKTNPNQHRWLSGDTATLVIAGS (2)
DTTAPSLSVVFYFLALYPDHAEKVYAELLTVNRTDQNALARLPHLNGTINESMRLLLAVL
TFGYRVTPPEGLTIEGTFIPGSTKICTPRYSIGR
(1)
LECAYEQPNDFIPERWYRRCELIKDKRAFAPFGV (1)
GRTACVGKHLAMVQIPSVVTSLVSQYRIEFAPGENNGEAVERDMKDQLTARPGKFHLLFMPR*
>CYP669A3 Aspergillus niger
e_gw1.4.1307.1|Aspni1
65% to CYP669A1P
MSTAIRQYHHRIIRKVEKLVNLIQAEGHRPILINEVMYWFAFDSMGDFAFSMDFKMMENQEWHQVILLFRSALALLGPLS
PAIWIPRLAFAFAPGLLWAKWWFQMLAFCDQCMERRMKQTLKDKDIASFFIEDHSTSTDKRRKMWLSGDTATLVVAGMGL
SKLSHLNGAINETMRLLPAVLTFGTRVTPPEGLTIADTFIPGGTKICAPRYTIGRLESAYERPKEFIPERWYSQEELIRD
RRAFAPFGVGNTSCVGKNLALTQIRLVAAALVIRYRISFAARNPDGERVEGEMKDQLTAQPGPCWLEFSPRDD*
>CYP669B1
AAGI01000217.1 Phaeosphaeria nodorum SN15
46% TO
CYP669A2P, 45% to CYP669A1P
221162
MAIVPFCLGVIMHLGIFIRGEWHLQAPHIVLGHVLVFTLLLVKQLVSGISTWYGVALPFVV 221344
221345
YLCGLLGSMAVYRLFFHRLRSFPGPRLAVLSKLWHVWLCRDSKNHLVLESWRQKYGT 221515
221516 FVRT (1)
GPSEITIFHPAGLEWLDGPQNRNARSDWYDLLHPSV 221692
221693 QVFSRDPAIQVARRKVWDKAMSLS (1) 221764
AVKQYYQRIKNHVLELESIISAQNSKPIIMNDLLYRMTFNVLKDIGFGQANEEVEDGAS
KLGGSLTIIGPTNPAPWILRMAFALFPGVWNIPHWFKFLEMTQGI
(0)
PESVDIASFFLEDAQRKEADMISREAVGGDCGVILLAGS (2)
TSGPSLILLFYCLARWPEHAEKIRQELRNVDYNDMAALSALPHLTATINESLRLYPA
GPTFGSRVTGPEGLNCDGVFIPGGTKVVAPRWSTGR (1)
LEEAYEAAHEFIPERWYSKPELVKDKRAFAPFSM (1)
GRNSCGGKKVAMSQMRLAVAVLVSKYSIRFAPGTTDEMSVENDMRDQLTPLPGDLKLVFEKLE*
>CYP670A1 Aspergillus nidulans AN7066.1 29%
to 67A1 34% to 628A1 53 clan
MDDFKIYYYASAGAGIAGILSHLVYFIRGEHHQYAHRWITRALAGTAAVA
IATLRLTDWQPLLSLILTALISTSYFLGLYSSIGIYRVFFHPLRRFKGPF
WARASNLYHMYIIRKSDNYLVMKKMHEKYGPIIRTGPANLSVNDPAAIPL
VLSDRATCVKGPWYDRSLPLVNLHTVRDKRVHDARRKVFTKAFTPSALRE
YEERVAVHCEEFVRQMTRLSGKPFDASEWFKYFAFDVMGDLGLGREFHMM
TSETNRWIPTLLETSMAHVGPTSPVPWMAPILHNLPWAGRGARAWLEFVG
SQVKERTQKKSDRRDQILSHLVEAYNQSEKKNIDYQWLRGDTRLTIVGGS
DTTAATLTFLFYHLAQNPSHVDKLRAELEPLLNGQPRLDPKDVSKAQHLN
GVIQETLRLHPAIPSGFPRTTPPEGITINGTYIPGGTTIVIPVYALQHDE
ANYTHAEEFIPERWYSRPELIKNRDAFLTWNIGTNGCIGRALALTEMRNL
VTYFIHHFSRVKFAHGEDGKALLTETKDHFTVGVKPLRLIFEK*
>CYP670A2 Coccidioides immitis
85% to CYP670A1
CIMG_04862.2
MDCTFMTPCAVAGGVGVLSHLLYFIRGEHHKYAHRWITRIFAGITVLAVSVLRVTEYQFLRTLILTILLSTSYFVGLYGS
IGIYRIFFHPLRKFKGPFWARASNLYHMCMIRKSDNYLVMKKLHKQYGPIIRTGPANLSINDPAAIPIVLSDRAKCFKGP
WYDRSLPLVNLHTVRDKKVHDARRKVFSKAFTPTALREYEERVVVHCEEFVRQMSRLSGKPFDASEWFKYFAFDVMGDLG
LGKEFHMMTTETNRWIPTLLETSMKHVGPTSPVPWMAPILHKMPWAGKGARAWLEFVGSQVKQRTQKKSDKRDILSHLID
AYDQTEKKDIDYQWLRGDTRLTIVGGSDTTAATLTFLFYHLAKDPSQVEKLRAELEPLLNGKPQLDPKDVSKAQHLNGVI
QETLRLHPAIPSGFPRVTPPEGVTISGTYIPGGTTIVIPLYAMQHDEANYANAEEFIPERWYSKPELIKNRDAFLTWNIG
TNGCIGRALALTEMRNLITYFIRNFSTVRFAPGEDGTKLVTETKDHFTVGVKPLHLIFE
>CYP670B1X # Aspergillus nidulans
Renamed
CYP5076A1
>CYP671A1 revised Aspergillus nidulans
AN8338.2 AACD01000150
MGIVTALATFLSPDLTRTAFAFCVLGVASHQCIRHGEIDNRLRPLSALYL
LAFLGLCLCYVRIFSLSWPRALGETILAASSFNLGLLTSIITYRAFFHRL
RHFPGPWMAKVTRISAVLKAVERTQYHLDLKE MHRKYGDFVRTGPREISV
NRPSAVYLTSGPHSVCTKPTWYSHVSDDITKVSLNSTRDPEVHRRRRRAW
DRGFSMKALPTYEPRLQHKVDVLVSQIRSRIDRPLNITQWTMYLAFDVMG
LVGFSKDFRQLEDAVEHAAIEELHGQMLMYGILRPVPWVLTILGATLGLA
GKYGQFMTYCVARTAERKAEWNASEDKVPQDVISWLFKASDEKDQSAPPG
EQALNEDGQLLIITGSDTTSGALANAFYYLAKHPAVYKKLQAELDNAFSS
GKQSPKINNETLRKLPYLEAIINETLRLKPAVPSGQPRQTPPQGLQIDEV
WMPGDTIIIVPQYVIQRDDRYFPSGDEFIPERWLDEKDSLIKHEEAFFPFQL
(1)
GRYGCVGKQLALMEMRLVIARIAMEFDLAFAPGETGEAFDRDAKDTFTFN
IGPLMLDFKPRSA*
>CYP671B1 revised Aspergillus nidulans
AN6101.2 AACD01000104
195432
MNSLLFREALQHASSTDISKLLLSAATLGVLSHVSLFRSLPVEEYLYGLLGLYTATVVAVTVLYLTAT 195635
195636
AFSP LQVLLRVGCISAAFNTGLASSIAIYRLFFHRLRRFPGPRLSKLSRFYDAYLAGKGL 195815
QYHVEIAEMHKRYGDFFRT ()
GPREICIVRKSAVPLLLSPQSKCGKSTFYAQAQTEAEYC
NVHQTRDFEDHRRRRKAWDRGLSVKALATYEPSIRAKADLLVLHIEKNRG
RAIDATKWSMFLSFDIMGKVGFGKEFNNLSTGVEHPGIKAIHDHMAILGV
MCHVPWLLNLISNLPGASFSMAEFFKWCEDEIVQKHRSWDIKETPQDITS
WLLKAYVHKEVSAAPTANALHEDSRAVIVAGSETTATTLASILYFLCKNP
EILAKLQLLLDEAMPGGSSEWTYDKIKTISYLDDIINETLRLRPAILTGG
YRVTPAEGLQVDEVYIPGDVNVFVPTQLIQTDERYYVDAKRFVPERWNEK
KEMIQDGAPYFPFLYGPYVCPKKNLALMSLRISVSKLAQLYDIHFAPGEN
GELFETRTLDTFTTTLPPLHVQFLSR*
>CYP671B2P Aspergillus
oryzae RIB40
AP007157.1f revised genomic DNA, SC023
join(618168..618393,618483..618641,618711..619251,
619318..619721,619797..620050)
sixth P450 out of 8 on this accession, one stop codon
55% to CYP671B1
VLSPRYAFGLAVDETSVYPDATQQ possible intron remove after TKRK
MDFISFLHQENFKEVLETDLLQLGVS
AALLGVLLHITIFRTSFCVENHIYNLLGLYATVVLFLFYAYFTITVLSL
MQALGRVALLTTLFNTSLNTSISIYRLFVHRLHPFPGPFACKLT
RFYSAFLAAKNIQYNVELKRLHKQYGDFVRT (1)
GPR*ISILRNTALPLSYGPQTGCRRSTWYGHVDVDDTK
ICMALSHDFNDHRRRRRAWDRAFSIISLSVYEPRVIAQAKKLMAQVEANQGKPLDATT
WSMLFTFDIMGDIGFG
KNFGNLTTGKAHPAISAIRDNMRVIAVVSHLPWLLNMLGKIPG
AAAGYQGFFKWCTDQVETKRK (0)
SWDHDEYPQDII
SWILKAFIDNDVSAPPSEPALHDDSRVVVIAGSDTTALALASIIYFLAKHPQILQKLQ
AELDNAMPNGPRSWTYDKAKTICYIDDIIHESLRLRPSVSGGGYRVTPAEGLQIDEVF
IPGDVNVFVPQQLIQTDERYYKFSKEFIPERWGEKKVEWGTDKAPYFLFSL
GIYGCVGKNLAMLSLRV
AVSTLAQRYDIRFRTGDILER
CIGYIHHFSAAFASCVSPKEIVNTTPFLRLLQVFFILHISGVKVRT
>CYP671B2P Aspergillus flavus
98% to CYP671B2 Aspergillus oryzae
stop codon is conserved in both
AFL2G_04121
MDFISFLHQENFKEVLETDLLQLGVSAALLGVLLHITIFRTSFCVENHIYNLLGLYATVVLFLFYAYFTITVLSLMQVLG
RVALLTTLFNTSLNTSISIYRLFVHRLHPFPGPFACKPTRFYSAFLAAKNIQYNVELKRLHKQYGNFVRT
GPR*ISILRNTALPLIYGPQTGCRRSTWYGHVDVDDTKICMALSRDFNDHRRRRRAWDRAFSIK
(1)
SLSVYEPRVIAQAKKLMAQVEANQGKPLDATTWSMLFTFDIMGDIGFG
KNFGNLTTGKAHPAISAIRDHMRVIAVVSHLPWLLNMLGKIPG
AAAGYQGFFKWCTDQVETKRK
SWDHDKYPQDIISWILKAFIDNDVSAPPSEPALHDDS
RVVVIAGSDTTALALASIIYFLAKHPQILQKLQAELDNAMPNGPRSWTYDKAKTICYIDDIIHESLRLRPSVSGGGYRVT
PAEGLQIDEVFIPGDVNMFVPQQLIQTDERYYKFSKEFIPERWGEKKVEWGTDKAPYFLFSL
GIYGCVGKNLAMLSLRV
AVSTLAQRYDIRFRTGDILER
CIGYIHHFSAAFASCVSPKEIVNTTPFLRLLQVFFILHISGVKVRT
>CYP671B3 Aspergillus niger
fgenesh1_pg.C_scaffold_9000394|Aspni1
65% to CYP671B1
MQLSSSVVSLADIRAVLESDLLSLAASAAGFGLLSHVSLFRTNFPVEDYLFILLALYAVAVLSTAYAYLTLTQFSVAQAL
LRVILISSAFNTGLISSIGIYRLFFHRLHHFPGPVGAKISRFYNAYLAGKDLQYNVEIARLHHEYGDFIRTGPREVCIVR
KSAIPLLFGPQSKCNKSTWYAHVSTNPKYCSVHCTRDHDDHRKRRKAWDQGFSIKALGIYEPRVKSKADLLASHVAKNLG
QPIDVTAWTMFLSFDIMGDVGFGKDFHNLTTGVEHPAIKGVHDHMAAGATLLQVPWLLNILCRIPGAVSGYSSFFKWCAD
EIERKQKTWDANAYPEDVVSWLLKAYVERSVSAAPSRMALNEDSRAVIIAGSETTATTLATVLYYLAKHPSVLAKLHQKL
DEAMPGGADDWGYDKVKDITFIDDIINETLRLRPAVMTGGYRVTPAEGLQVDEVHIPGDTIVFVPVQLIQTDERYYESAK
EFIPERWSEKRYEMKTDGAPFIPFLTGPYICPGKNLAMISLRTSISTIAQQYNFSFAPGETGEAFETGAQDTFTTSLPPL
QLAFQRRQK*
>CYP671C1 Nectria haematococca
fgenesh1_pg.scaffold_25000016
Necha1/scaffold_25:46690-48703
45% to CYP671A1, 43% to 671B1 A. nidulans in
CYP53 clan
Nterm 46% to CF878446.1 tric078xn06.b1 T.reesei
mycelial culture
VGPREISITRE may be an intron seq, or AP007157.1f is short.
Note AP007157.1f does have this seq with one
stop codon
Remove two introns from N-term in the model and IENKNK after AKRA
MATLGLVLSAALDSAPLVTAEVSFLLGIVAHLVIRPFEIDSQAWAIVFAYLG
VITTLLLTYIQVCKF TIIGAILRTALVSNAFNVGLAS
SILIYRAFFHRLHRFPGPFPAKLSRFYAMKNAAKALKANEEVQKLHEIYGDFVRV
(1)
GPREISITRESAISIIYEPPNQCVRSTWYSQVSDDVRKISLHTTRDLTAHKLRKKAWVRGLGFR
(1)
ALAIYEEKIASKVEILMSQIAEKQGTPMDMTLYAAFFGFDVMGQV (1)
GFSKDFNMLDSGYKHPAIQALHENMVAVGVLSTVPWLMSMLGKIPGATGSYARFADWCAREFQAKRA
(0)
EILKDHDPRDVISWLLRAEDENDRSAPPGEGAFQEDSRLMIVAGS (2)
DTTAVALTNA (2)
LFFLTKSPTCYRKLQAAVQAQFPEGVKDWTYEKIKLIPYLEYVIHETLRLKPSAPGGLSRL
TPPQGLQIDEVFIPGDTIVSVPTYTIQRDERYWENALEFRPERWENLNPEKVAWIPFSRGQYSCPGKNLA
FMELRMVISRIALEYSLAFPPGDDGEAFDKGARDTFTLNVPELPIIFTPID*
>CYP671D1 T.reesei
CF878446.1 tric078xn06.b1 T.reesei mycelial culture
CB906402.1
EST 46% to 671C1 (N-term to C-helix)
FSIIYADSCAPTVGGFLVNHKHLLEVLK
MEEALEFFIIDLSSSWRVTTCVSLLAGIASHHLVFRPYEIDTYIWQLIFIYIASMATVFA
TYIHKRGYQVIPASLWTFFIASVYNCSVIASILVYRALFHPLRHFPGPFLAGLSRFYAMG
RMIHSRKGFEDIQGLHQEYGDIVRVGPQELSINRLSVIRAIYGAHAQTTRPPWYAQMSRH
AAXSSLVNTRDVAMHKMRKKVWERALG
>CYP671E1 Aspergillus niger
gw1.5.1493.1|Aspni1
43% to 671C1
WLDVALLTGLFGNIVVYRLFFHRLRNMPGPIAARVSRHYAAYHTIKDAQMHYTVQRLHQQYGDVVRIGPREVSVCRASAI
RAIYGPPSRCIKGPWYDQVTNENDKKPLFTIRDPRVHSKRRRQWDQAAKGINHYHNALQKQSRILIEKIREHQGRPMDVT
NWINCYTFDVMGHIVLGAELGMLKTGKKIPELQVIDEGQRYIAVAGTMPWFPPLMLGIPGLSAILNPFRHHCHKLFDAKR
AAMTKGSEPKDIISWLIQAQDNGDPGAPPTDQAIKDDAWFIIAAGSDTTASALINAVYYLATHPGAQAQLQREIDERLPE
GIEGLSYENVKDLPYLTAVINETLRLKPSVLDGLVRVTPPQGLKVDEDLHLPGDVVVSVPTFAIQRDGRYWEDADQFRPE
RWASIENPANMPFIPFSRGSYDCVGKSIAWMEMRMALAMLVGEYHIQLSDEEQRAFDGKELDNFAMSVPALWATFRPR
>CYP672A1 Aspergillus nidulans AN6434.1 31% to 567B1 53
clan
MSLVMAVPHAFSVSDFGDIPTVLVSALSFILVSVWIKTSIDISQLETKLG
FLSGRSAYKFNSLHKKYGKIVRFAPNQLSFNTIKGMRNIYGAGLGKSNTF
LKTGFYKAISRRNIFTATDPYYHATVRKLFSPSLSPGCMAAHEPVIKGCI
ARFHALVKQRMQSQKAISLNDLYYSLSVDMVSEVLLGKSLGCIERGRPFF
WTEQLPRIFYWATIRDQFKGSGVPTLIKWMLRQILRKGIRQRSEEARMRL
IREQLKATHTRRDVMVEVLERADSSTLPEDEIAENFSAIMLAGFHTTSHA
ICATIWLVLSHPETRERLQNELRTAFQSTDEISLDVLAKLPWLNAVITEA
LRVYPPVPLGGARISPGAYVDGFVAFLTGPQVEVSTSLYALHHNGEYFKN
PYKFAPERWVNPESTDRKEAVQPFLLGSRSCIAKYFAQQMLLLTLASFFV
EFDGQYVGKVKDWTTESRCYAFWELPELKVQLQERFASAEVSE*
>CYP672A2 Aspergillus fumigatus Af293
GenEMBL
XP_751418.1 also EAL89380.1
67% to 672A1
MVLVAMSLPSGPFPELAYPVIPFPVLAVFLVPCLVLLAIRLAPKGPVIKGVPGSFVDLYLCG (0)
IGTKLAFLSGRSTYRFHSLHQSYGNIVRFAPGQATTNTVKALR
QIYSTGTGKGAAFLKTSFYRNISRRNIFTAADPVYHASVRKLFGPSFTPGSMHAHAGVIRECILRLHEVI
RDKLETHNTISLNELLYCHSVDTVSEVLLGKPLGCLKRGKPYFWTEQLPRIFYWATIRDQFEGSGIPTAI
KWLLRRFLRKGIRLRAEQARMRLINEQLHAPHTRRDIMVEVMERSGGSELPEDEIAENFSAIMLAGFHTT
QNALCAVIYLVLTHPEAHVKLVQELQTAFASADDISGDVAAQLPYLNAVITEALRLYPPVPLGGPRVSPG
AYVDGVYIPAGTEICTSLFALHHNPEYFSSPYEFLPERWTEPGSTDRKEAVQPFLIGSRACIAKYFAKQM
LQLTLAGFFLEFEAEHVGKVRDWQRQSRCYAFWDVPDLQVKLRKRLID
>CYP672A2 Neosartorya fischeri
94% to CYP672A2 Aspergillus fumigatus =
ortholog
NFIA_102170
MVLVAMSLPSGPFPELAYPVVPFPILAVLLVPCLVLLAIRLAPKGPVIKGVPGSFVDLYLCG
(0)
IGTKLAFISGRSAYHFHS
LHLSYGNTVRFAPGQATTNTVKALRQIYSTGTGKGAAFLKTGFYRNISRRNVFTAADPVYHASVRKLFGPSFTPGSMHVH
AGVIRECILRLHEVIRGKLETQNTISLNELLYCHSVDTVSEVLLGKPLGCLKRGKPYFWTEQLPRIFYWATIRDQFEGSG
IPTAIKWLLRRFLRKGIRLRAEQARMRLINEQLRASHTRRDIMVEVMERSGGSDLPEDEVAENFSAIMLAGFHTTQNALC
AVIYLVLTHPEAHVKLVQELQAAFASADDISGDVAAQLPYLNAVITEALRLYPPVPLGGPRVSPGAYVDGVYIPAGTEIC
TSLFALHHNPEYFSCPYEFIPERWTEPGSTDRKEAVQPFLVGSRACIAKYFAKQMLQLTLAGFFLEFEAEYVGKVKDWQR
QSRCYAFWEVPDLKVKLRKRLVN*
>CYP672A3 Aspergillus niger
fgenesh1_pg.C_scaffold_20000080|Aspni1
75% to CYP672A2
MVFAMALPSGQMPEINPSNLSLPVMAVVIIATKFNFVTGRSAHYFNSLHVSYGKVVRFAPGQATTNTIKGLRNIYGAGSG
KGSTFLKTGFYKGISRRNIFTASDPVYHASVRKLFNPSMTPSSMQAHANVVLECTSRLHDVINATLKSTDTISLNRLLYC
HSVDTVSEVLLGKSLGCLKRGKPYFWTEQLSRIFFWATIRDQFAGSGVPTMIKMMLRYLIRKGVRSRAEQARMRLINEQL
TASHNRRDIMVEVMERAATSDLPVDEIAENFSAIMLAGFHTTQNALCATIYFVLTHPEAHAKLISELQTAFASPEDVSGD
VAANLPYLNAIITESLRLYPPVPLGGPRVSPGAYVDGTYIPAGTEICTSLFALHHNPEYFNEPYEFIPERWTDPESTDKK
EAVQPFLVGSRSCVAKYFAKQMMQLTLASFFLEYEAEYIGPVKDWQRESRCYAFWEVPDLKLKLRKREAI*
>CYP672A4 Aspergillus oryzae
Supercontig 18: 1723786-1724196 (-) strand
MVFVALYLPSGQMPEGYSPAMISYPTLVVVL (0)
FIFLVILFVQVQPKGPTIKGVQGPFLDIFCCG (0)
IATKLAFISGRSAHHFHALHESY (1)
GKIARFAPGQATTNTIKALRNIYGSGTGKGSAFLKTGFYKSISRRNIFTASDPIYHSSVRKLFGPSMTPGSMEA
HAGVVRECTLRLHDVINSRLESKTILSLNELLYCHSVDTVSEVLLGKPLGCLKRGKPYFWTAQLPRIFYWATIRDQFDGS
GVPTVMKWLLRRFLRKGIRLRSEEARMRLIHE (2)
QLKASHTRRDIMVEVMERAETSGLPESEIAENFSAIMLAGFHTTQNAL
CAVIFFVLTHPESHAKLVRELQGAFHSAEDISGDVVQQLPYLNAVITEALRLYPPVPLGGPRVSPGAYVDGVYIPAG
(0)
TEICTSLFALHHNPEYFNEPYEFIPERWTEHGSRDKKEAVQPFLVGSRACIAKYFAKQMMQITLAGFFLDYEAEYVGTVKDWQ
RESRCYAFWELPDLKVKLHQRRQA*
>CYP672A4 Aspergillus flavus
79% to CYP672A2 Neosartorya fischeri
99% to CYP672A4 Aspergillus oryzae
AFL2G_10674
MVFVALYLPSGQMPEGYSPAMISYPTLVVVLFIFLVILFVQVQPKGPTIKGVQGPFLDIFCCGIATKLAFISGRSAHHFH
ALHESYGKIARFAPGQATTNTIKALRNIYGSGTGKGSAFLKTGFYKSISRRNIFTASDPIYHSSVRKLFGPSMTPGSMEA
HAGVVRECTLRLHDVINSRLESKTILSLNELLYCHSVDTVSEVLLGKPLGCLKRGKPYFWTAQLPRIFYWATIRDQFDGS
GVPTVMKWLLRRFLRKGIRLRSEEARMRLIHEQLKASHTRRDIMVEVMERAETSGLPESEIAENFSAIMLAGFHTTQNAL
CAVIFFVLTHPESHAKLVRELQGAFHSAEDISRDVVQQLPYLNAVITEALRLYPPVPLGGPRVSPGAYVDGVYIPAGTEI
CTSLFALHHNPEYFNEPYEFIPERWTEHGSRDKKEAVQPFLVGSRACIAKYFAKQMMQITLAGFFLDYEAEYVGTVKDWQ
RESRCYAFWELPDLKVKLHQRRQA*
>CYP673A1 Aspergillus nidulans AN5433.1 29%
to 57a1 53 clan
revised frameshift after SGKR
MALLESAVVLQVFRDVTPMAILATLLLTTFLTYVVYMRHFHPLSQCPGPF
FASLSNTYKAYYVYKLTIHEKLLELHNTYGPIVRVGPNHLHTWKGDAIAL
IYKGGRSMGKSEFYDAFTAFRPNLFGGRDEDIHALRRRQLSHGFAQVSVA
KLEPLIDGQMAILISKLRHYARTGQAFDLKHALNLYVLDILGEVAFAKAF
DVQNTEDNEKLHAINDHLLLAGVIGELPCQNFTKFLSRLSPVPWMRRLMK
SRNKLKEICAGCVRFKIENLEATKSRPDLLRSLVEATDPESGKR
KAEEEINSEAFAVL (2)
VAGSHSTAGTLTLLFWHLIQNPSIMRKVQAEIENTLGPLKDRTSYPIAGIESTLKY
TMACVRENFRINPVFTMPLWRRVGKSHVLEIDGHHIPEGTNICISNYVLH
HNPSVFGPDHNTFVPEKWLDESYNREKGRYLIPFSVGHRMCIGRNLAMTN
ILKSVCTLATLFEFEPVEKKKDVRVISPGIGEMKGGFEVRVRVREVKRGS
YKNALST*
>CYP673B1 Nectria
haematococca
e_gw1.10.303.1
Necha1/scaffold_10:98331-99989
MDFDRLLAITSDHRFVVVTALIALFTGLYVFYYRNLHPLSKYPGPFLASFTNLWKVQQLWSLHLPDTLIA
LHEKHGDVVRIGPNQLSFRQGDAVPKIYKAGRTLAKTPFYDGFTSFNPNLFGTQDEE
(0)
VHSLRRRQMAHAFSLQSIKEMEQYIDEHLVQFRRNLDEYSKTGQVFDLKELIAFFVLDVLGDLAFRCQFN
SQVEKDASKLPPINDHIFLACLLGMIPDLMPFIKAISPWTPVPWLQQLLAARRDLKNLTAKCVSSRMADT
GAARKDLITSLINAVDPQTGARLTELDIQTEAFAFI (2)
VAGSHTTSGTLTLLFSHILQNPAIHAKVVGEVDATLGKLESDIVPIE
GLETKLPYLMACLNENFRINSVFTMPLERRVTAREGFEIAGHVIPKG
(0)
TVVFSLNHVVHHNPSIWGADHNKFDPSRFLNKDGERLERFLSPFSMGHRMCIGRNMAMTNMLKLVATTFK
NYHLEMEDPTQIISTISVGISEKEGPLMCRVRRRC*
>CYP673B2 Fusarium oxysporum
58% to CYP673B1 Nectria haematococca
FOXG_13065
MSLELESFITWASSLPILLQTSAVVGFLGLVYIVYYRYLHPLAK
YPGPPLASVTNLWKTYHLWNLHLPHTLVRLHEQYGDVVRVGPNDLSFRNPDAVNTIYKGG
RQLQKTGFYDGFTTFNPNLFGTQDEE
(0)
IHAIRRRQMAHAFSLQSIKEMEHFVDSHILKLRNNLDHFCDSNQDFDLKDMIALYVFDVL
GELAFSRSFDSQDERDLARLPPINDHIYLACLMGMTPDALPWIKKVLPFIPIPWLQRLFN
ARAQLRNLTAACVRQRIEAGSSGRKDLLSCLLVAVDPETGSKLTELDINTEAFAMI
(2)
VAGSHTTSGTLTLLFSHLLQNPEVLNKVIQELDSNLSNHTGQVISYQALEKDLPYTRACM
HENFRINSVFTMPLPRKIMTPGGLVIQGCQIPQK
(0)
TTVFALNHVVHHNPSAWGKDHDQFIPDRFLGPNSKDLQGYLSPFSTGHRMCIGK
NLAMMNILKVLSTVLRNYKLEMVHPQEPVDTLSVGISEKKGRLMCRISKR*
>CYP673B3 Fusarium verticillioides
86% to CYP673B2, possible ortholog
FVEG_12478
MADMSLKIESFTNWAIGLPMLLQTSTVVGFLLLGYIVYYRYLHPLAKYPGPPLASLTNLWKTYNLWNLHLPHTLVRLHEQ
YGEVVRVGPNDLSFRNPDAVNTIYKAGRQLQKTGFYDGFTAFNPNLFGTQDEEIHAIRRRQMAHAFSLQSIKEMEHFVDS
HILKLRKSLDNFCDTNQEFDLKDMIAFYVFDVLGELAFSRSFDSQNERDVSRLPPINDHIYLACLMGMTPEALPWIKKVL
PFIPNRWIKRLLNARAQLRDLTAACVRQRIEAGTSDRKDLLSSLLAAVDSETGSKLTELDINTEAFAMV
(2)
VAGSHTTSGTLTLLFSHLLKNTEMLNKVIEELDSNLSSHTGQVIPFAALEKDIPYTMACV
HENFRINPVFTMPLPRKIMTLGGFTIQGQQVPQK (0)
TVVFALNHVVHHNPSVWGKDHDQFIPDRFLGPNGKELQSYLSPFSTGHRMCIGKNLAM
MNILKVLSTVLRNYKLEMLHPEERVETLSVGISEKKGGLMCKMSRR*
>CYP673C1 Aspergillus oryzae
GenEMBL
BAE61747.1
43% to
673B1, 37% to 673A1
MTLLQNIVSETPLAAGSALLTAIIVAYVIYQRYLHPLAKYPGPFLASITDLWQVHQFLSLQQPYNLTALH
ERYGPIVRYGPDKLSITHESAVPTIYQKSAKSMPKTEFYDAYGAAHPNVFGMRDEVMHSVRRRHMSHSFS
LSYIKEMEEYLDLNIRILKDKIRYHSEIGEVFALKKALHYYMIDVLGELAFSRSFGVQEADDESRIPPVI
EHSLLAAVTGAWPTMTMTLKRWLPYMPHAGLRRLFAGRKACADLASSSVQRRLRDLNDGESSVGVQNRKD
ILTNLIKAKHPETGERLTQTDLETEAFGFIIAGTHTTSATSTLLFYHLLHNPDFMRKCTEEIDSNLPSLG
PSETAYSITAAEASLPFLRNCIRENFRITPVFTMPLARRITDPAGVTIEGEHLPQ
GTSVAVCNHAFHHNP
VVWGEDHNIFNPNRWNDPNVGAKARLLMHFGLGGRQCIGKAVATTNIYKLLSTLLKEFTFELADEQERVD
VDKGLYKGRIPKLFSVGISDLQGPLLVRARVR
>CYP673C1 Aspergillus flavus
99% to CYP673C1 Aspergillus oryzae
AFL2G_09403 revised
MTLLQNIVSETPLAAGSALLTAIVVAYVIYQRYLHPLAKYPGPFLASITDLWQVHQFLSLQQPYNLTALHERYGPIVRYG
PDKLSITHESAVPTIYQKSAKSMPKTEFYDAYGAAHPNVFGMRDEVMHSVRRRHMSHSFSLSYIKEMEEYLDLNIRILKD
KIRYHSEIGEVFDLKKALHYYMIDVLGELAFSRSFGVQEADDESRIPPVIEHSLLAAVTGAWPTMTMTLKRWLPYMPHAG
LRRLFAGRKACADLASSSVQRRLRDLNDGGSSVGVQNRKDILTNLIKAKHPETGERLTQTDLETEAFGFIIAGTHTTSAT
STLLFYHLLHNPDFMRKCTEEIDSNLPSLGPSETAYSITAAEASLPFLRNCIRENFRITPVFTMPLARRITDPAGVTIEG
EHLPQG (0)
TSVAVCNHAFHHNP
VVWGEDHNIFNPNRWNDPNVGAKARLLMHFGLGGRQCIGKAVATTNIYKLLSTLLKEFTFELADEQERVD
VDKGLYKGRIPKLFSVGISDLQGPLLVRARVR*
>CYP673C2 Aspergillus niger
e_gw1.1.1529.1|Aspni1
70% to CYP673C1
MTVFIQTITSTPMTSAGLFLALILIVYSIYQRYLHPLAKYPGPFLACLTDLWQVYQFLTLKQPYNLTELHAKYGPIVRYG
PDKLSITHEGAIQAIYQKGGRGMPKTECYDAYGAAHPNVFGMRDEEQHSIRRRHMSHGFSMSYVKEMEQYLDVNIRILRD
KIREHSSHNRAFDLKKALHYYVVDVLGELAFSQSFGIQETDDEARVPPVIEHSLLAAVTGAWPAMTTTLKKYFPLVPYKP
LQQLFAGRKACADLASECVRRRLGDFGGNGMSKSDDRKDILTNLISAKHPDTGKHLTQTDLETEAFGFIIAGTHTTSATT
TLLFYHLLHNPRYMEECVKEIETNLPPLTYGETAYSVSAAEAALPFLRNCIRENFRITPVFTMPLARRVMRPTGVMIDGQ
HIPQGTSIAVCNHAFHHNPDVWGDDHNIFNPYRWENTEIAAKARLLMHFGLGGRQCIGKTIAMTNIYKIMSTLLREFNFE
LADKQAQRNGMPELISVGISDLKEPLMVRAHVRVQEKVEWAHNL*
>CYP673D1 Mgr015 Mycosphaerella graminicola
49% to 673A1, 47% to 673B1, 39% to 673C2
MASPVAVLLLLLAFSYIVYQLFLHPLAQIPGPRLAAFTNLWKVYHIYSTQLHEVLLELHKVHGPVIRIGPNDVH
(32 aa gap)
NLFGTQ
DDDLHALRRRQLAHGFSQKSIVAMEDILDERLTVLCDRITMFAETGQPFDLKDCISRYVLDILGEAAFSCSFNAQIPGAG
EFEQVPKAINGHVLMGSIIGELPFQSLNKRLLAGSPFKWMREIVSNRILLRNTCAECVQARLDGGSNKDRKDLLQSLIKA
KDPETGASLTTIDINTEAFAMLVAGSHTTAGTLGLFFAHSLRDPQIMARLVSELESKLDPLDQSTGRQTHAITGLEDSLP
YLMACVRENFRMTPVFTMPLWPRVTASEGLAVWNTVIPSNTNVSASNFVQHHDASVWGADHAKFDPDRWLDGRTEGLSAA
LIPFSLGHRMCIGRNLAMTNILKTISTLLTRFEITMMKDAKKESVRFESYGIGELQGTLMCTARFRNI
>CYP674A1 Aspergillus nidulans AN7969.1 32%
to 532A 53 clan
MAMSFSYSPADIFWPCVKLGVFLALVYITSLIVYNRYFHPLRHFPGPAWA
AISPLWYFKRIRSGNPQDVQHSLHERFGDIARIGPNILAVRHPDAIETVF
GTKNGKAWRKAAFYDSFDPHIPNARTDSFSERDDAKNAERRRLVGGLYAQ
DNVLRYEPCVDRLIHLFQQRMQEHSESGKVFDMSVWLERYTFDVVGEIFH
GRREGFGMLRDGADYNGWCYLMGVMPDIGAATTYLPWGFRSLYLLSQLVF
QSSRDGVRGMLDVTKQAERATLERWEEMKKGKVLSESDILTGLLDMVQER
GKNDSVMASWTVADVVTEVWAVIWAGSDTTATALTSIFYHLHRNPCKLAG
LREEIDAAFEDGRLRFPIRFNDARKLPYLHAVILESMRVHPSLGIGLPLE
SPADGANIGGTYIPGGVEVIVNPAAVHFDERSFGADAKEWIPERWLVDAE
ATRRMERSMLQFGYGPRMCIGRHISNIEMYKLLPALIRNFEFEMLVDSWE
VKGSWFHRAHNVSADPPPLDKQSFSENGGNLRS*
>CYP675A1 Aspergillus nidulans AN4643.2
AACD01000079 revised sequence assembly
MDLIVPNYFKYVNIDTLLLFPLALLVSLAYCIMWITYTRWFHPLAQFPGP
FWASVSRIWTVLHVLPGNAEKTQRKLHEKY (1)
GPIVRIAPDELITSDPAAVKTLYGVKSGTLKTDFYLAFRPPW (1)
ARFPDHFSAIGGKQH
ADRRRIVSAVYSMSSILQSEQYVDACIDLWEEKLGEMADRKESFDLWLWTRM
(2)
YAYDVIGELFFSKMFGFLEAGGDHLGYIAATD
DLIPVQFLAGIMPTYVRPLFLLTGFLLPKVRGALTALASLTEATNATIKR
RLFALSELDSNTKPQRADILGKLLDISHKNGKALNFELADIKMESFSGF
(2)
FAGSETTALTLSGILYNIFRNRAVYEKLTSEIDAAITSHQLSRPHIT
YTEATRLPYLGACIKEGIRMHPITGVSFPRHAPSCGCEVGGYWIPGNTRV
GVNPAVIHFDKSVFGEDAGIFRPERWIEAGANVANMDCHIMQFGMGARVC
LGKNISMCEIYKAIPQLLHSFTFEMGAEEPVKTTSYWFHKPVAIHVKVRRR*
>CYP675A2 Aspergillus oryzae
GenEMBL
BAE55129.1
63% to 675A1
revised 3/23/2009
MDLLRLRDRSLLGQGALVAFVTYWAVWIIYTRWFHPLAKFPGPFWASVTRAWTLLHVLHGDAEKRQMKLHAKY
(1)
GSVVRIAPNELVTSEPEAIQTLYGARSFTAK (0)
TDFYFAFRPPW (1)
ARFPDHFSSEGGKQHGERRRIVSHVYTMTSILQSEKYIEKCIAVWLEKLGQMADRKESFDLWIWTRMYAYD
VIGELYFSKMFGFLQAGHDHLGYIDATEDLVPIQFLAANMPTYVRGLFMLTGILFPKVRRALRALGDLTD
ATNAMLKDRLAAIQSDSEDKPQRHDILGKLLEISQKRGKELDFVLDDIKMESFGAFFAGSETTALTLSGI
LYHILRNRSVYEKLTAEIDTAVQCNQLSTPHISYNDAIKLPYLTACIREGIRMHPITGVSFPRHAPSSGC
TIGGYYIPPNARIGVNPGVMHFNKTVFGEDADQFRPDRWIDGDVSKMDRYIMQFGMGARTCLGKNISMCE
IYKAIPELLKFYTFELAGDEDMQTTSYWLYKPVAIDVNVRRR
>CYP675A2 Aspergillus flavus
97% to CYP675A2 Aspergillus oryzae
revised 3/23/2009
MDLLGLRDRSLLGQGALVAFVTYWAVWIIYTRWFHPLAKFPGPFWASVTRAWTLLHVLHGDTEKRQMKLHAKH
GSVVRIAPNELVTSEPEAIQTLYGVRSFTAK (0)
ATLGYVRTQYYPQQRLIGVA
TDFYLAFRPPW (1)
ARFPDHFSSEGGKQHGERRRIVSHVYTMTSILQSEKY
IEKCIAVWLEKLGQMADRKESFDLWIWTRMYAYDVIGELYFSKMFGFLQAGHDHLGYIDATEDLVPVQFLAANMPTYVRG
LFMLTGILFPKVRRALRALGDLTDATNAMLKDRLAAIQSDSEDKPQRHDILGKLLVISQERGKELDFVLDDIKMESFGAF
FAGSETTALTLSGILYHILRNRSVYAKLTAEIDVAVQCNQLSTTHISYNEAIKLPYLTACIREGIRMHPITGVSFPRHAP
SSGCTIGGYYIPPNARIGVNPRVMHFNKTVFGEDADQFRPDRWIDGDVSKMDRYIMQFGMGARTCLGKNISMCEIYKAIP
ELLKSYTFELAGDEDMQTTSYWLYKPVAIDVNVRRR*
>CYP675A3 Aspergillus terreus
58% to CYP675A2 Aspergillus oryzae
ATEG_07776.1
MLDNIPDRQLILQAVVLGFATYWAAWICYSRWFHPLSRYPGPFWASVSRVWTVMHVLRGDAEKAQKSLHARY
GRVVRIAPNELAINDPQYIKKIYGINSRFTK (0)
SDFYLSFRAPF (1)
SRYPDHFTSTDEKVHAERRRIVSHVYTMTSILQSENYLDECTAVFLEQMG
KIADRKGTFDLHEWARMYAYDVIGELYFSKMFGFLKSGCDHLGFMASTDTLIPVMTLSAVMPTYIRSVFMFAGILFPRVR
NALTALGNLSKAAETAVQERLAQRDESKDGPERADVLNKVLDIYHGKKADFDLDDVRLEAFGAFFAGSDTTAIFISGTLY
HIIKSRDVYDTLTREIDQGTRNGLLSTPFITYNEAVKLPYLSACIKEGMRVHPSTALTFPRNAPKGGCDIEGHWIPETAR
VGVNAAVVQFDKSIFGDDADTFNPSRWLGPDADNMSRYILQFGAGSRTCMGKHISMAEIYKIIPALLRSYHFELDGNGDL
KTSSYWFYKPANITTRVQRRQV
>CYP675B1 Nectria
haematococca
gw1.22.151.1
Necha1/scaffold_22:515970-517756
50% to 675A1, 43% to e_gw1.1.1095.1
add cyan region
MILPISAETLKGVSFSFPPLLTCACLFLGLFILYWCF
WIAYTRHLHPLAKYPGPFLASVSRSWLVMQVAGASADKTQRKLHSRL
(1)
GPIVRIAPDEVAISDPDAIRSIYSINSGFTK (0)
TDFYLPWRPLW (1)
AKYPDHFTSLDERLHASRRRIVNSLYSMTNIVRAESGIDLCTDLLMSRMREYADTGEVVDISSWVQM
(2)
YAFDVIGQLFFSRMFGFLKEGGDHRGYIRSLDTLLPILAVASAMPTYIRTLFSLAGTMFG
SVRGALTAINEIERAAESCIAERQEILNNGETVERKDILSALFEIIQEKGDKVNFGLTEAKVEVYVAL
(2)
FAGSDTTAAAISSILYHLVKSPQAYQKLTEEIRQGAASGELSVPHVRHSEAVKLPYLEACCKEGMRMHPSVG
LTLPRNVPKGGGMVCGEWFPEGTRVGVNAAVVHRDKTIFGDDANEFRPERWFRDDAKNMDRYMFQ
(0)
FGGGSRTCIGKN (0)
ISLCEMYKMIAQLLLSFDLEDACTEWKTSNYWFNKPSN
VNIRVRHRSRFIN*
>CYP675C1 Nectria
haematococca
e_gw1.27.138.1
Necha1/scaffold_27:47233-48946
46% to 675B1, 42% to 675A1rev A. nidulans
in CYP53 clan, in CYP675 family
This gene model seems correct
MALQIIFDYVLAFPNNLAVILGLAILYWVGYSIYSVFFHHYSDIPGPFWAKVSRLWLAKQVLSGTVDQTQRALHAKY
(1)
GSIVRIAPNEVSISDPDAIKTIYAVKNAFSKTDFYTPFAPHLSPNEDLFTQRDEKHHSYRRRF
VNNIYSLKSVLESEPFIDQVTSVFRTRLDEFAVSGQSIDLGLWLQMYAFDVVGELFYGKQFGFLKNSHDY
ENYIDSLDALLPALSTICVLPAYVRPLKVFGSLVPQIRKG
KICYDKIVLAAKQVVKERQQ LMMTDK (0)
KVLLTKRCSHF RTDILDKLFQLS
ADKEDFSIPDIETEAWVSIFAGSDTTSIATRSILYHLLMTPDALAKLTNEV
DNAVADGTLSDPIKHSEAVKLPYLSACCKEGFRVHPSVGMSMPRHVSEPGATICGRYFAPGYRVGMSAAV
VHWDKSIFGQDADVYNPDRWLRPEGKEMERYLLHFGAGTRTCIGKN
(0)
IALAEIYKLIPELVHRYRFKVIEPEKVQKHSFWFFKQTGFNVRVHRREGVKGGLLVQ*
>CYP675C2 Fusarium verticillioides
57% to CYP675C1 Nectria haematococca
FVEG_09420, no F. oxysporum ortholog found
MIIDIILERFTCVSAPAALALLVSSTAALWLMTLLYSYYFHPYADIPGPFWAKL
SRFWLVRQVLRGDIHNTQRALHEKYGPIVRMAPDEVSISDPAALKV
IYVVNAGFTKTEFYTPFAPHLSPHEDLFTQRDEKIHAQRRRFVNNLYSLS
SILESESYVDACIMTFKAQLDEFVAQSDPFDLGLWLQMFAFDVIGELFYG
KQFGFMEDRHDYQGYIETLDTLLPAVATSCVLPFYLRPLQVLGHLIPPLH
KALKGYDDIVVAAKETVARRQRQVDKGTVQSRPRLKKYVLADPRI
RSDLLDKLFNIAASKGDFTLADVATEAWVSLFAGSD
TTAIAMRAILFNIIRNPKVYERLLAEIDQASAQGLLSNPAKYSEAIKLP
YFIACCKEGFRVHPSVGMSMPRHVPPAGVNIAGRYFPGGSRVGMSAHVVHF
DKGIFGQDADCYNPDRWLQPGAEVMERYLMHFGAGPRTCVGKNISITEIHK
LIPSLLQDYEFRLAEPNKDLKYSNYWFNKQIGLHVLVSQRKK*
>CYP675D1 Fusarium oxysporum
42% to CYP675C1, 42% to 675C2
FOXG_14720 revised
MLLDFAFTNTWLIPASLATYWLGWLVYTLTFHPLSKIPGPYLARLSRLWYLHKIWT
EDVEKHERALHAKHGPLIRIAPDEISCSD (2)
PEAFASIYRFSNALDKGRFYEPYNTTGFSPHGDVFSCKNDKKHGQRRRITSNIYSMTNVASSEEYIDYCSNLLTERLGQ
FADSGKPCDIGEWLHW (2)
YTFDIIGELFYGRAFGFIDEGKDQNDWIKSLDKMIPFVCLMGVAPPILRPLIGLGTMISSAGNEIRKGV
(2)
KNIGESSSRLMKEAYASRIEAP
RTDMAQQIFSIFEKNGERMDFRWGDVEQESYGALFAGSDTTAIAFRSLFYHLM
HNPEAYSRLEIEIDRAVDDGLLSMPATYKEAIKLPYLCACIKEALRIWP
(1)
GINLILDIALPRTVPPEGLTICGQFIPGGYVVGINAAVMHFDKRVFGQDADSFNPDRW
MDTARANYMDKYMMAFGGGTRTCLGKNIALIELHKLSPQLIRNYRFEFYDRNRTRWHTRNTFFARQEGIVVRVKHREH*
>CYP675E1 Mycosphaerella fijiensis
42% to CYP675B1 Nectria haematococca
42% to CYP675C2 Fusarium verticillioides
39% to CYP675A1 Aspergillus nidulans
estExt_Genewise1.C_160602
MFTLPILVLPLLSCVAWIVYTGYVHPLSKVPGPWLAALSRFWYIYHMRKGHFDQVNRQLHAQYAAGPVVRIAPNEVSIDS
PEAAHIIYNNRPGQRFTKVRIVCWVHRKRMSSKALIGLGKHENLFMDLDEDHHASRRRIVANLYSMSSILESESYIDDCT
NLLEDRLTGFYKRGEVVDISRWFQMYAFDALGELVYGEAFGFLESSSDVGGWMALIESLSPFRQTLLLLPAYLRKPYMMS
GLLYKSVKLAITDNAKRVNYARDLVHKRMSELKDNGGAAESQGRRDLLSKMFELSATKGDKVDFHLPEIEMESWVNIQAG
VDTTAIALQAILYYILKDSRVHRKLLSELDAAHQDQRITIPLKYSDALKLPYLAACIKEAMRLHPSVGLQLPRHPPPEGC
HISGYYFPHSARVGVNAAVLHYNQDVFGEDAASFRPERWSADNAAEMDRHLLTFGAGTRTCTGKHISLAETFKMIPHVLL
KFDMKLAEPGMELTKQDWWFHKIKDFRVSIQRELRP*
>CYP676A1 Aspergillus nidulans AN8952.1 36%
to 629A1 53 clan
revised 2/10/2009
MSSPWKVMDPNLADMHQIASFLGLHRVALFLIAAVIVRVLYRRYWSPIRD
VPGPFWASFSSLWRVYHVVKGHTEQQILKLHKEH (1)
GDFVRIAENEISVAHPDAVKQLLHANLAKGTFYSVFSLPDYRYVN
QMSELDPTRHIQKTRNLSAGFSLSNITKTEPYIDRCLKVLSRQLDGLAAS
DAPVHFQDWFSFFAFDVLGEVTFSKSFGFLQEGLDIRNAIANTGSLVYYI
SIMGNYVWFHNLTLGNPLVSRLGLQPNSHIFDTCLLAIDSRKNNPELRHD
MMQRWLDMRASHPERMSEEDIFGAAVANVGAGAETISSTAQAVIYYLLKN
PQYLATVRKELDEAQAKGELSDVIQYGEATKLPFLQACLKEAYRFHPGVC
HNLPRISPKGGMTIAGRYFPEGVILSVHPWVIHRNADIFGADCDTYNPTR
WLQGDTKRMDYFLIHWGAGYNQCPGRNLAQFELSKVLATVLRDYDIKLMN
PKSEWRFETRFLAVPYGWPCQIQRRKRGMVQVAA*
>CYP676A2 Aspergillus niger
gw1.2.1506.1|Aspni1
62% to CYP676A1, revised 2/10/2009
XP_001399153.1
MPVLFASAWLPGSLTSLPVSLPFLLFVFVVAIAVKRRYATSIRDIPGPWLASISSLWQVYQLIKGHTEQEIVKLHRRY (1)
GSFVR
IADNEVSVAHPDAVRLLLHANIAKGSWYSIFSLPDYHYVNQMSELDPQRHIRKSRNVASGYALSNIIKSEPFVDALLGLL
EEQFDKLIASGQPVEFDRWFNYFAFDVVGEVTFSSPFRFLETGTDIRNAIANTRALALYIAIMGHYVWLHNLTLGNPLLS
RIGLQPSSHIFDTCLAAIDSRKKNPDVRLDMMERWLHVRREYPDRMDEAEVFGAAVANIGAGADTTSATLQAFFYYLLRH
PQYLQKLRQEVDEAHTRGDLSHVVSYAEAAKLPYLQACIKETYRYHPATGTGLPRVVPAGGLTIGGRHFTEGTLLSINPW
AFHRNPDLFGPDCDDFNPERWLDPDRARQMDPFLIHWGAGYNQCPGRNLAHFEISKVTATILRDYDIEQVDPKKPWSFET
HFTAVPYGWPCWLRRRQPAA*
>CYP676A3 Aspergillus clavatus
73% to CYP676A2, 63% to CYP676A1
ACLA_060010
MGVFALTTGLESPSTPGFWVLAFLSLVATFAVKRKYSTALRDIPGPFLASFSSLWKVYQVWKGHTEEEMIRLHKKH
GYFVRIAENEVSVSHPDAVRQILHAKIVKGPMYAIFSIPDYHYVNQMSELNPRRHIEKTRNVAAGYALSNIIKSEAYVDTLLQL
LKTRLDGLSESGTPVEFDRWFNYFAFDVVGEVTFSKSFGFVESGTDIRNAIANTRALALYIALMNPYVRLHNLTLGNPLL
SRLGIQPSSHIFDTCLAAIDARKNNPDSRNDMMERWLHVRATYPDRMAENEVFAVAVANIGAGADTVSATLQALVYHLLR
SPGHLQRLRAEIDAAKAKGELSAVVQYAEAQRLPFLQACIKEAYRFHSAVGLGLPRVVPKAGMTIAGRHFTEGTILSVNP
WVFHRNPALFGADCDTFNPERWLDKERCAEMDSYLIHWGAGYNQCPGRNLAHFEISKLAATLFRDYEIEQIHPKQEWMFE
NHFTVVPYNWPCRIRRR*
>CYP677A1 Aspergillus nidulans
AACD01000158.1 FGSC A4 revised
MDAYTSLLALAGALISYSLSYVCYTFYWHPLARFPGPPLAALTRFYRAYI
DISWKHSFVHHLGELHKKY (1)
GDIIRIGPNE (0)
LHFRSPAAYLEIFNPANRWDKEERLYHSFGEDRSSFG
YLRYAEAKERKDILSRRFSRKAVQDAQKIVEGI (0)
VLDLCKTLGQNSEEAVDLFYAFRCMSVDVIT (1)
YLCFANSVNAVHAPKYESPLLLAMDASMTVFPAFKHFGFYKEMIMNC
PPKLSKILSPATAGLVDLQTLLKAQIEDLTSDPSQLEKLPHNTTIYHELLRP
EAYRTKTQPSKGSLYEESQALMFGGADTTGMTLMHGCFYILQEKSRGIYE
RLKTELVEAWPSLDGAAPTWEELEKLPYLTAVIKESLRMSPGVASPLPRV
VPKSGAVITKTHIPGGTIVSQSSHFVHTNPDIFEDPHSFIPERWLGEKGK
SLDKWLLAFSRGPRSCLGQQLAWAELYLTYAHVFRKFDLQIDPSR
(2)
SPNELKWKDTFLAHYLGPHLKAKLTPVIS*
>CYP677A2 AAEC02000027.1 Coccidioides immitis RS
64% to 677A1
CIMG_06137.2
1175231
MKPFVLTEFGFQSHWILLAALYLAGWAVYQGIK
1175330
TLYWHPLAKFPGPRIGALTRLYKTYVECVAQGSFVHLLEEHHARY (1)
GDIVRVGPNE (0)
LHFSNPATYLEIYNPSNRWDK 1175686
1175687
EESLYHSFGEDRSSFGFLTYKEAKERKDVLNRMLSRKAILGSQGIVQEK (0)1175833
1175898
VVELCKSFERKKNSTVNLFYAFRCMSIDVIT (1)
YLCFGSSVDAIN 1176077
1176078
APDHQAPIIIAMDASLPVFVRFKHSAFYKSMIVNCPPAISKIVSPLTAGLVDLQQ (0) 1176242
1176296
LLKGQIKEMTEDPSTLEKLPHSRTVFHELLRPEAYKSRTVPCADSLYEEAQALMFGGADT 1176475
1176476
TGTTLMHGTFYILKQPEVYRRLKEEIHAVWPNLNTLPDLTDLEKLPYL (0)
1176476
TAALKESLRMSPGVASALPRIVPPSGAKISGQFIPGG (0) 1176790
1176862
TVVGMSSHFVHRSETVFEKPNEFIPDRWLGDKGSQ 1176966
1176967
LDKWLFSFSHGPRSCLGQN (2)
1177023
1177088
LAWAELYFCFAHLYRKFDIEMDPSS (2)
PRDLQWRDRFL 1177267
1177268
PEYIGPHLKAKITPVAS* 1177321
>CYP677B1 Mgr062 Mycosphaerella graminicola
47% to CYP677A1 Aspergillus nidulans
MAVSITLLLSGLVAAAVTQLAWTFLTNVFRHPLAQFPGPLLASTGWYKTWQEVFRGRNWIDVLRELHAQYGEVVRVGPNE
LQFADPEAYLDIYNASNRWSKEATLYQSFGEDASSFGFLHYREAKQRRDVLAPLFSRRAILDLQRVVRGIMDRLCVHLAK
ENAEGKSSDMLFALRCFTLDTIVTYCFAQDIHATEAKDFQAPVVVAMDASLPTFVVFKHFSAVRKLVFSFPGWLTKMTAP
GLGGLVDLQQLLGAQVKEVASNPQLLKQTSHPTIYHRLLDPEANEAAGVPSQQSLYEETQALLFGGADSVGNTVTIGLYH
VLQSPKMISRLKAELLSVWPDLQSQPRVEVFEKLPFLAAVIKESLRLAPGVTAPLPRVVPSSGATISGRHIPPGAIVGVA
QVMVHSNPDIFVSPEKFDPERWLGREASSLERWLVPFSRGPRACLGQTLAMCELQVAFAGLFRRFDIQLDEASTDSLAWR
ECFLPHFNASHTRAFCKPVVS
>CYP677B2P Mycosphaerella fijiensis
synt_with_mycgr.14__52
58% TO CYP677B1
frameshift with missing C-term
MAVTIAKAIGGLILAFICYKLGSTFYNAFLHPLTRFPGPKSVATEWYKTVEEVFKGRNWTDVLKELHGQDGDIVRVGSNE
LNFSNPNAFHEIYNNANRWDKEETLYHCFGEDRSSFWFLTYKEAKQRKDVLGDLQGLVKKNIERLCIALEKYGRAKKPSD
MLFALRCSTLDVVTRYCFAKDVKSTEVKDFQSPIVIAMEACLPSFVVFRHFEPIRQIVFSLPGWLTKLTNPALAGLVDLQ
ELLGAQVNEVVKNPQTLQKTPHATFYHRPMDQEANKATGVPSPGSLYEEAQALFFGGAESSGNTTMIGIY &
YHILQSPAILKRLQEELRSAGSDRSMIPPLEQLEKLPYLTAVIKE
>CYP677C1 Aspergillus terreus
48% to CYP677A2
ATEG_02825.1
MISASSTRGPFRAELEGGIPWRWSLLPFGAILTLIWVLLRRLHHAGLSRFPGPPLAAVSGLYKTYIEVLQQGCFVHKLEE
LHARYGDVVRTGPNELHFSSPAAYMDIYNMNNRWDKDPALYEAFGESDSSFGRLSYRDAKERKNVLQSLFSKKAAVQAHR
LVESKVVELCKAFEKSEGGPVDLLAAFRCLSIETIA (1)
YIFCGQSLGAIESPTFDAPIIQS
MDEGVSYIMLMKHFPILQLLMNHCPPWMSKLLSPKANGMVDFRN (0)
FLEKQVRSLVADRRELQKLPHTSTIY
HLLLGPEVANPPSQLSILEETQTQVFAGESSGLTLMHGSFHIIQTPRVYRKLREELMAAWPDLEQPPSLATLEQLPYLT
(0)
NATVKESLRMGGGATSPLLRVVPQTGAKIDGKFVPPG (0)
TVVGSSSHFVHRNGDVFDRPHECIPERWLDERRADMEQYLVAFGRGPRRCIGEN
FAWVILLTAMAHFYRKFDVELDPSS (2)
PAKLEWKDRFVPVYSSPHLTVRLQKVSQ*
>CYP678A1 Aspergillus nidulans AN6485.1
poor match 53 clan
MNYVAYIPLLAIALLAWVIIRRLLFNPLLGIPGPWTARIFGFYEFYHNIW
RDGEWCKTFPELHKRYSSPVVRIGPNHVHINNIEAYEHIFRLGTDFYKDE
SFYTCADNHGSVFSLSDRDDHRERRKVLAPRFSKQAAELAAPKIQARLQD
LVQFMVKQSRKGEGCNITDLFRAVAINWVADVFLGDCGDWVNYEARKLDM
LEDIDGLSALIPTLRFFPYLATLNSLLPSSVVNYLTPSAVAGFKKICKDH
TRPLLNTPTKEMARRTEASVAELLIFHRLENTGKPPTLDYLAEEAFAFID
AGVDTTGGTLVTALYHVLKSPEILRKLRKELDEAMRRQAKSTDIDPRKLG
ELPYLNAIIKESHRIWPAIPGPLPRVVPPAGINIGSYFIPGGTTVSATHH
SLHYNETIFPEPHKFNPERWLKEEKSEGGRYLNPYSRGTRACIGINLAQI
QLRLTLTHLFGQYELELCDPVPSRHEWKDHFVAHPKEPIFVKFRERKGQV
ESVVQSGDEEGRGCKTNFVM*
>CYP678A2 Aspergillus clavatus
59% to CYP678A1 Aspergillus nidulans
ACLA_059710
MSDVARWLVDCCFSCSRGWLLLWSL
VVLVAHRLIQHLFFHPLRHIPGPWSATLCGWYEFYTNVWLDGQWCK
TYPYLHEKYR
SPVVRVGPDHVHIKDIDTYEK IFRNGTNFYKDHTFYTCADNDGSIFSLCDRDAHRARRKALS
PRFSKQAAEADAPGILQQLRRMEAFIVRQSDEGKDCNINDLFRTFAINIVGKTLLGDCGDLVTYEDSKPELLDIVDGMSM
MIPTLRFFPYLAAINSVVPSFISNLLVPAGVLNFKKICEDYTRSRMDKPIRSDIERSSASVIELLVAHSHDITGGPPNLD
YLAAEAFTFIDAGVDTAGRTLAAAVYHILRDPIIEKKLRDELDKSDAWTSGALEVDVRKLWNLPYLNAIIKEAHRIWPAL
PGPLPRVVPPEGLQVDSYFIPGGTIVSATHHSLHFDEDIFPEPNRFNPERWLRNDRTDLDRYLNPYSRGSRACIGINLAQ
AELLLAVADMFRLLDLELCEPIPSGLTWKDHFVAEPISPILIRARPREVSF*
>CYP678A3 Neosartorya fischeri
58% to CYP678A2
Aspergillus clavatus
NFIA_045580
Note: this seq has no ortholog in A. fumigatus
MATMNFAPSSPLQLDAGVILQSLPIVAALIILFCILKLGHNFFRSPLKHIPGSRLSAFCGWDEFYSNIVLNGQWCKTYPE
LHRKYDSPIVRVGPNHVHVNDIDIYEKIFRMGTDFCKDHTFYTCANNDGSIFSITDRAKHRERRKVLSPRFSKQAAEAGA
PGVLRRLQQLVDYMTDQTRMGNTCDATDLFRALMINVVGEILFGDCGDLVEYGPSKPALLDSVDNLSSLIPWLRFFPYLG
TVASMFSTSISERLEPAGVYNFKQKCKEHTLPRMDQPISDAMDRSHASLIELLIAHSHQVQGKAPTLQYLTEETFTFIDA
GVDTSGRTIAAAYYIVRNPGVQQKLRAELDESSVTDQAGKHVDVKLLGTLPYLNAVIKEAHRMWPALPGPLPRIVPAEGL
TVGKHYVPAGSVISASHYMLHFNETIFPQPHEFRPERWLEGHSSEQDRYLNPYSRGSRACIGINLAQLQLQVTLGHLFSH
YQIQLCEPIPQSLDWHDHFVATPRSNVIIKILPRDQGY*
>CYP679A1 Aspergillus nidulans
AACD01000170.1 Aspergillus nidulans FGSC A4 revised AT not AG
MTLTPLMESFHILAVLLSSQKCLMVHLSPLITAALATT
GLVLYLIATRLLFHPLAKVPGPRLAALTKWYEFYYDVVCDGEYVKHIEKLHIIY
(1)
ASIIRTGPNQVHV
NDAGVYKRTFAVASPFPKSEFFYSSVGVGDAIGAMTDTKKHRVRRSILGP
RLRAKAIAPYTPSLQKLVIACMDIMAGKARQGKVINLLRYTRALTVDVIS
DFTFGRPMGVVNEAEEMPDLLNDLEVFGRHFHILKHFPISRKLLDIIPES
FARKLMPLPGFFELREKATTAVNEAVVERQAGKTISNNTDGASFLDLLLN
QIDENPSVLVDEGCAFITGGSDTTGFTMENATYLILSHPHILQSLLQELD
TSPHIRDTFDLDHILRLPFLTAIIKETLRLYTPAPSPLPRTVPAEGIDVH
GHFLPGGTILTHSLYLIHHNPVLFADPKSFKPERWLGTQGKVLEQYYVPF
SKGSRSCIGMALAYHEVYTYLSLLFSRFEMEIFETSQSDMDWREHFFVKR
NGQLRIRIVRDRWTGEAFPTRAVEADLR*
>CYP680A1 Aspergillus nidulans
AACD01000006.1 Aspergillus nidulans FGSC A4 revised
MDLKESSLRFLASDIRSVIWRLATLISVVALLRTAWVVIYRIYFHPLAKV
PGPLLARITWLYSFWYNIVTKRFYLRVQELHEQYGPV
IRITPDEIHLSDP
ENLEKIYFVGSRYPKDAAFYGAFGADRSVFTAPSPDVHRVKRAALNPFFS
RKKVLELEDIVQDKAEKLVGRMKKAFNSTGAIDLHHGFRAISVDVITDYA
FGDSYNFLDRDDFGIDFFNGFRDTGPALWTFQQFPVIQRVAKKMPFWLAE
RLSAPLALRRSQHMSSRAQVLKVKAAVERDEKVSRTTIFHELLRPDAAEG
YAVPNVDELSSEAQNILGAASDTTGNTLTIAAYNVVRNPDIYARLSAELK
EAFPNPEGRLEFVALEKLPYL (0)
TAVIKEGLR (2)
LSFGVPGRLPRVVPPPGAEFNGYHVPPG (0)
TVVSMSSWIIHHNENIYANADRFNPDRWLDPSRAKVLERYLFSFGKGTRGCIGMP
(2) 140353
LAYCELYVTLGRMFREFDNLKTPAKSSEELIVDDGFSAYHPEKNNKFVFSLS* 140166
>CYP680A2 Nectria
haematococca
fgenesh1_pg.scaffold_2000610
Necha1/scaffold_2:1945379-1947146
49% to CYP680A1 AN0338.1 Aspergillus nidulans
This gene model seems correct
MAVIFPNLGSLCHLVAQWWRTVVVGGAFYTIATIIYRRFFHPLAKVPGPFLPAVTKKYAWYFNVPCGGKF
YKEIERLHDVY (1)
GPIVRISPNEVHLTDPKHYDTIFGVKSDFYKDPGFYGALGIESATFTTISNDVHRRRRT
ALNPFFSRRKVLELESFDVIHDKVEKLCRMVSTDRAAGRPTNLHAAFRAISVDVITDYAFDDSWNQLDDE
DLGEWFSNMIRSSASMFWTFQAFASLRVPIQSLPDSVAKHMSPSVADFVACKD
(0)
RTRKQVQDVQARINQGV
QPKRTTIWHQLLDPNATEGHVVPTINELVDEAFGICTAAADTTGNAMSMAAFHVVTNPTIYDTLKKELQE
AFPDPDARLSSSELEKLPYLTGVIKEGQR (2)
LSYGVLSRLPRVAPKGGVELEGYYLPEG (0)
TVTSMSAWMMHHNSEAFPNPEVFDPTRLTDPSTFHERDKCLVPFSRGRRMCIGHDLAWCELYVTLGTLFR
RFPDLRAYEVDAEDMVYVDYFTAYHPLEKRRFRVVSGDMEKLSIHA*
>CYP680A3 Aspergillus niger
e_gw1.1.1307.1|Aspni1
63% to CYP680A1
MISVHVLLLTVSVLSIVLLLRCVWTIAYRLFFHPLAHLPGPLLARATHLYAFWYNMQGGSFYLQVQKLHEQYGPVVRITP
DEIHLSDPENCEKIYYIGSRYGKDPQFYGAFGTHKATFTAPSPDVHRVKRSALNPFFSRKKVLELEDIVQDKADKLVRRM
RESFSSTGCIDLHHAFRAISVDVISDYAFGNCYGFLGKKNFGAEFFEMIRGFGPAFWFFQQFPAIQGLSLGTPFWLAKLT
SEPLTRMMLHREGSRRQILKVKDAVDRGEKGSRTTIFHQLLHPEAAEGHVVPTVEELEDEAYIMLAAAADTTGNALTIAA
YNVVRNAKIYKRLTEELKQAFHDSEAQIDFVALERLPYLTAVIKEALRLSCGVPGRLPRVVPDVGAEFNGYHVPPGVCNK
HGTIIVNFANIFLDCSSLSRSTCSLSARGLDNVSGCRICTDFCRLAYCELYVTLGRLFRQFDNLKTAQKSREELRYNDYF
SSYHPAEYNK
>CYP680A4 Aspergillus niger
fgenesh1_pg.C_scaffold_71000001|Aspni1
67% to CYP680A1 aa 316-512 seq
gap upstream
PFWLAKLTSEPLTRMMLHRE (0)
GSRRQILKVKDAVDRGEKGSRTTIFHQLLHPEAAEGHVVPTVEELEDEAYIMLAAAADTTGNALTIAAYNVVRNAKIYKRLTEELKQAFHDSEAQIDFVALERLPYL
(0)
TAVIKEALR (2)
LSCGVPGRLPRVVPDVGAEFNGYHVPPG
TVVSMSSWTMHHNEELFPKSETFDPNRWTDPVMSKSLEKYLFSFGKGSRQCIGMPLAYCELYVTLGRLFRQFDNLKTAQK
SREELRYNDYFSSYHPAEYNKFIFEKAS*
>CYP680A5 Aspergillus clavatus
ACLA_032120
63% to 680A1
AAKD03000006.1 895518-893676 (-) strand
MFLSSLPDIPHLAAIIGAVSVVRFIWVVIYRLYFHPLSKVPGPLLA
RAFFFYSFWYNYHDGRFYLQIEKLHQQY (1)
GPIVRITPDEIHLSDPENLDKVYYVRSRYGKSAPFYNGFGVNSSTFSTASHELHRVKRAALNPFFSRKMVFELEDVV
QQKAKKLVTRMQKAFVSSGRIDLHYAYRAISIDVITDYAFNNCFNSLDKEDFGAEFFTVIRDTVPALWFFQQFSFLHDFA
LNMPLWAARLCNQMLAKLMCYRADLKDQVLRVQASVSSGEKVERKTIFHQLLRPDAADAYTVPTTKQLADEAYVIVTAAA
DTTGNALTIATYNVVTNPKIYERLTAELKERFPDPEAEMDFAALEKLPYLTAVIKEGLRLSFGVVGRLPRVVPQPGAEFN
GYQVPEGTVVSMSSWIMHHNEGLYPNSETFDPERWLNPVTYNTLDKYLFAFGKGTRQCVGMQLAYSELYVTLGRVFRQFD
DLKTRKRTKEELIYDDYFSSYHPEAYSKFIFERASR*
>CYP680A6 Aspergillus terreus
67% to CYP680A5
ATEG_04863.1
MARADLLQLLGFTLVAATVVRGLWTVIYRLYFHPLAKVPGPFFARAFYFYSFWYNLNGGRLYLQIQKLHEQYGPVVRISP
NEIHLSDPENCDKIYYVGSRYGKDPAFYGAFGTEKATFTTPSPDMHRIKRSALNPFFSRKKVLDLEEIVQEKAAKLVGRM
RAAFESTGRIDLHHGFRAISVDVITDYAFNHCYGFLDEEEFGVEFFNMIRDFGPAFWFFQQFPAVQPLALGTPFWLAKLT
SGALTRMMLHHEGSRRQILRVKDEVDNGKKAARTTIFHQLLSPDAAEGYVVPTVEELKDEAYILVAAAADTTGNALTIAT
YNAVRNPKIYQRLTAELKEAFPDPAMKMDFVSLEKLPYLTGVIKEALRLSFGVVGRLPRVVPDPGAEFNGYHVPGGTVVS
MSSWIMHHNEDLFPQSEVFNPERWTDPEKARSLDRFLFSFGKGSRQCVGMPLAYCELYVTLGQVFRQFDDLTTPAKAREE
LLYNDYFSSYHPEQYNKFVFKRGSNGQ*
>CYP681A1 Aspergillus nidulans AN3609.1 34%
to 551A1 53 clan
MSFLGLLLSAVFPVAIYGIFLVVYRLYFHPLRRFPGPKLAAATFWYEVYY
DWFKGPYPGSSWNLDRLHNQYGPILRKTPDELSIRDPDYVDVFFAGGRRD
RYSRQGKEAQGSVQSTLLGSDHRRRRGALTGFFSKRSLDTLEPFIMDKVE
QLSASVEENFLKTGNILEAGVAFGALTLDTITDYCFDQSFGCLSKPDLAP
EWRRTFWDMLESIPFLKNWTFFAEMFFWVPQWVVKHTNPAMEQFFIMQAA
IRAKVARVTMEWEQDQALQLQGKDPFMKGKRKRTIFYDILNSAVLLPEDK
TPKRMAEEAFGMVVAGGYTTGKAMANLMYHLHANPKWLERVREELDSLMP
SPDQPVKLSDLQALPYLTACIKENLRISNIITDSIMLVEPVDTLTYKDWV
IPPKTPIGMTLYHMHMDEQIYPEPKAFKPERWIKGAEAKHDLDKYFAPFS
KGTRGCLGVNLANAQMYLGLGVILRRFDFQLFDVVKERDVDTVRDCFVGL
ESPESKGVRLRVMDKRE*
>CYP682A1 Aspergillus nidulans
AACD01000135.1 Aspergillus nidulans FGSC A4 revised 7/19/07
MAILWSYLFSSYAVIIGLVTSVYLLGLGIYRLFLHPLAKFPGPKYAALGR
WHEAYYDIYLSGKLIFWIEEQHKKYGPVVRIAPDELHILDADLWETIYTK
AGRVDKYDRMSSRFGNDTSVLATIPDSLHRVRRGALNPFFSRQRILGLQD
IIRQKLNIFIKRVEEYKALNAPMPINRGFLAFSEDVIMQYCFGHDYAALN
KRGWAPTLHDPIVNVTLAGNTALHFPIVPKIMNVLPQSWIAKLDPVYVPI
FQMQRIREIKDSLTGESPKIDKQTVFSDLIQGDLPASEKADRRLQDEAQL
VIGAGLATTGWALTVGTFYLLSNPKVLARLRRELDEAIPARNPENPSGAL
EWAELEKLPYLTGVIKEAVRLSHSTTSRNVRRLPKPITYKDWVIPPRTPV
SMTIPFLHLDEDIYPEPKSFIPERWLDNPKTKNGAPLERYFVGFGKGTRSCLGLN
(2)
LAWCELYLVFAAFFRFFDFELYETDFSDIELQHDFFLPFPKWDSKGVRVFVKERSA*
>CYP682A2 Coccidioides immitis
64% to CYP682A1 Aspergillus nidulans
CIMG_09899.2
MSYVVDTLTYGGLIWAAYLAGLVIYRLYFHPLAKFPGPRYAALSRWHEIYYDVYLGGKFIFHIEDLHKKYGPIVRIAPDE
LHVIDSDFFDTIFTKAGRVDKYEWLSNRFGNATSTLTTAPDSLHKLRRGALNPFFSRKRIINLQELVREKIAILVGKINE
YKESGAPMTISRGYMALVEDIIMQYCFARDYNHLETPNWKPIFHDPLMAISMSGNAALHFPLVPKIMECLPQSWVVKLNP
LYVPIFRLQNDLSQQIRNLKEDKVDAKDGRATVFFELIHGDLPASEKEDRRVRDEAQLIIGAGLVTTSWALSVGTFFLLS
NPEALAKLRRELGEAIREDKYSKTLLQWAELEKLPYLTAVIKESIRLSYGTSSRNVRLSPNSLKYKDWVIPARTPVSMTI
PFLNHDEEIFPDSHAFNPERWLNSPKTSNGSNLDRYFVGFGKGTRSCLGSNLAWCELYLIFATIFRYFDFELYKTDKSDV
ELVHDYFLPFPKLDTKGIRVRVKQ
>CYP682B1 Aspergillus nidulans
AACD01000150.1 FGSC A4 revised
MLSFGLANDAWGHPWVVLPLAVILYIV
VLGVYRLFFHPLSRFPGPVLAALTVWYEFYYDGIRRGLYTFEIQRMHE
KYGPVVRISPNELHVNEPSFIDELYAGSGKRRDKYPYSTCQFGIPDSVFG
TPGHDLHRLRRGALSRFFSKTSVTKLEPIIENAIGKLCTQLESYSGSQQP
VKMDMAFSCMTTDVVTEYAFAKSYNFLDSPTFEPNFHRPIVAGADLGPWV
KQFPVLLKVMNDLPKWILTRINPEAAVYIQFQEDLRRQIREVQSQVDKGE
SNGKIPTIFHELLTGDLPEQEKRIERLWQEGQIVVGAGTETTAWTLSVTL
FYLLDNPRIMRQLQEELERIIPDAAQSVTWHQLEQLPYLSAVICEGLRLS
YGVSSRLQRINPLGPLWVRSRDAKGGPHGKGRWVEYEIPKGTPVGMTSTL
IHTNPELFPDPHEFKPERWLDGAGKRHHSLDGYLLSFSRGSRQCIGINLA
YAELYMGLGLLIRRLGHRLELFETTSADVEIHYERFLPTPKDGTQGIRVL
VHPESE*
>CYP682B2 Aspergillus oryzae
GenEMBL
BAE64654.1
56% to 682B1
MTLISLSLLALSLWIIIRVLVIIYRLAWHPLARFPGPKFAAATSAYEFYFDAIKGGQYTFEIGHMHKKYG
PIVRISPHELHINDPGFIEELYPGPGKPRDKYAYATGQFG (2)
IPD (0)
SVFGAVSHDLHRMRR
GALSPFFSKAAVTKLEPVIYSAVDKLISRIEEVVESTGFVDLTMAFSCMTTDIVTQYAFAESSRFLENPD
FTPNFHEAILAGTRMGSWARHFPILFPVLRSIPIDILSRMSPETGVFLRWQESMRKKVSEIWQDQSALPV
KDKNVSPFGSTIFHELFHSDMPDSEKHPGRMWQEGQIVIGAGTETTAWTLTATTFFILDNPNILSKLRKE
LAATMPNRYEKPSCRELEALPYLIIIQEGLRLSFGVATRLQRINSEAPMIFRQKKTNDTIEEKVWEIPTG
TPVGMTAALVHLNPELFPDPHEFRPERWLDQDGQLHRGLDKYILSFSRGSRQCIGINLAYSELYMGIGIL
IRRLGDRMQLFETDRTDVDMVEDCFVPVPRRESNGVRVRLSAQ
>CYP682B2 Aspergillus flavus
AAIH02000253.1 99% to CYP682B2 Aspergillus oryzae
AFL2G_04898
12469
MTLISLSLLALSLWIIIRVLVIIYRL
12547
AWHPLARFPGPKFAAATSAYEFYFDAIKGGQYTFEIGHMHKKY 12419
12363
GPIVRISPHELHINDPGFIEELYPGPGKPRDKYAYATGQFG
IPD
SVFGAVSHDLHRMRRGALSPFFSK 12019
12018
AAVTKLEPVIYSAVDKLISRIEEVVESTGFVDLTMAFSCMTTDIVTQYAFAESSRFLENP 11839
11838
DFTPNFHEAILAGTRMGSWARHFPILFPVLRSIPI 11734
11657
DILSRMSPETGVFLRWQE
11533
SMKKKVSEIWQDQSALPVKDKNVSPFGSTIFHELFHSDIPDSEKHPGRMWQEGQIVIGAGTETTAW (1)
11360
TLTATTFFILDNPNILSKLRKELAATMPNRYEKPSCRELEALPYLI
(1) 11136
IIQEGLRLSFGVATRLQRINSKAPMIFRQKKTNDTIEEKVWEIPTGTPV 10925
10924
GMTAVLVHLNPELFPDPHEFRPERWFDQDGQLHRGLDKYILSFSRGSRQCIGI 10766
10707
NLAYSELYMGIGILIRRLGDRMQLFETDRTDVDMVEDCFVPVPRRESNGVRVRLSA* 10537
>CYP682B3 Uncinocarpus reesii
Remove intron in I-helix GTSCPTQQSYMSLNHIA
53% to CYP682B1, mid region has some questions
remaining
UREG_02363.1
MALLTDLGQFVAQHPYVVLCLLLVSFFSGRSIYRLYFHPLAKFPGPKLAAVTLWYEYYYDGIKGGQYTFEILRMHEKY
(1)
GPIIRISPHELHVNDPAFIDTLYAGSGKRRDKYPYYALQFG (2)
LPG (0)
SLFGTSDHDHHRLRRSALRRFFSKASITQLEPLIAKKIRDMCAIIETHAGTGKPVAISEAFSCLSSDIA
TEYAFGRSTNFISPDNPKFEKNFRRTIETGSMVATHSKQFPWIRPLSKMIPMY
(0)
GVGE
QVKALMDRTASGKEEG
GNTIFHELLSGQLPPQEKTFKRLEEEGQLIVGAGTETVGW
ALSVTIFYLLSQPETFAKLRGELEEAIPD
PSILPPVTVLENLPYLI (1)
IIIAEGLRLSYGVVSRSQRISPHEPLIFKPGPNYQKGCTEYVIPPGQPVGMSCYIT
HHDPELFPDSRNFKPERWLDNEGKRHRHLDPYLMSFSKGSRQCIGINLAYAELYLVMSAVIRIFGDRFKLFETTLKEVEA
KSDYFLPIPESEKGIRVLVRAK
>CYP682B4 Coccidioides immitis
70% TO CYP682B3
CIMG_08088.2
MALLAEIVQFIPQHPFAVLCLLVVFALSGLSVYRLFLHPLAKFPGPKLAALTLWYEYYHDGIRGGQYTFEIQRMHERYGP
IVRISPHELHINDPAFIDTLYAGGGKRRDKYVFYASQFGLPKSLFGTADHYHHRLRRSALRRFFSKASVTQLEPLITKKI
DTLCSLIQATAGSGRPVSLSDAYSAITSDVATEYAFGTCTNFVCPSNPYFERNFRVTLVKGLMVATHSKQFPWIRTISKM
IPMC (0)
EISKQVKDVMDGVSNGNEKGHNTIFHELLTGSLPPQEKTFTRLKQEGQLIVGAGTETVG
WSLSVITFYILAHPAVLEKLRKELEEAIPDPSILPSVTTLENLPYLSAVVAEGLRLSYGVISRSQRISPYEPLIFEPASD
QENHIKHVIPAGTPVGMTSYLIHHNPEIFPDSSKFIPERWLDQDGKRHRHLDPYLMTFSKGSRQCIGINLAYAELYLIIS
SLIRRFGGRIELFETTVRDVVPKKDYFLPVPDGDAVVQVLVRED
>CYP682C1 Aspergillus nidulans AN6787.1 34%
to 579A1 35% to 58A1 53 clan
revised 7/19/07
MELLRLLLDHPYAVAGAAVSVYIASIVIYRLYLSPIAHFPGPRLAALTVM
YEFYWEAIRHGKFTFHIGELHKKY
GPIVRISPTELHVNDPEYYEVIYSRDSPRNKYPYYQRTFNAPYAL
ITAEDHYRHRLLRSQLNPFFSIQRIRQLEPTLKALVDKLCRRLEELKGTG
QPIDIEYPLTCYTTDVITDYTMGEGGYHYLDEPDFIPQWQHMLCGTAKTL
VFIRPIAFLLPVLVAMPEALTAWLNPGMELFFAFQHRCRKRIAEITKRHR
ENGPLETKDGRQNLFDNVLNSNLPEQEKSEARLAQDMQVFVSAGAETTAK
AMSYIMFYLHNEPALLQRLKDELAPLGNDPSLVQLEQLPYLTSVMLEGLR
LSYGVTARLPRIAPYNALKYKDWTIPPGTPISMSCLLMHHDESIFPDSYR
FNPDRWMDPTERKHLEKYMVAFSRGSRMCIGMHLAR
SEILLVISSLLRRLNFELYETTVEDVRVAHDIFIPFVKLDSKGVRFLIK*
>CYP682C2 Aspergillus fumigatus Af293
GenEMBL
XP_748206.1 also EAL86168.1
69% to 682C1
MELFRLLLSHPVSSAVALGAVYLLWVVLDRLYLSPIAGFPGPKLAALTHLYEFYWDTICCGQFTFQIGRL
HEKYGPIVRISPTELHINDPDYYEVLYSRDSPRNKYEYYQKTLNAPLALLNTIDHHLHRQLRAQLNPFFS
STRIRRQEPAIKALVNKLCRRLDELKNTGQPLNIEHALTCYTTDVITDYSMGDGYHYLDAPDFIPQWHGT
LNGTAKTMVFIRPVAWALPLLLALPEAVTAWLNPGMELFFDFQRRCRKMIKRIVAAHNEKGNQGVQNEGF
VNIFDDILRSNLPAKNKSETRLAQEMQVLVSAGAETTAKAITYILFYLLNDPETMAKLKAELETVGEDPA
LVQLEQLPYLTGVMLEGIRLSYGVSARLPRIAPYNALKFRDWTIPPGVPVSMSCLLMHHNETVFPDSHRF
KPERWLDPAERKRLEKYMVAFSKGSRQCIGMHLAKAEILLAVSTLLRRMDLELYETTVEDVAIKHDIFIP
FPRMDSKGVRVLIKG
>CYP682C2 Neosartorya fischeri
97% to CYP682C2 Aspergillus fumigatus = ortholog
NFIA_040740
MELLRLLLSHPVSSAVALGAVYLLWVVLDRLYLSPIARFPGPKLAALTHLYEFYWDTICCGQFTFQIGRLHEKYGPIVRI
SPTELHINDPDYYEVLYSRDSPRNKYEYYQKTLNAPLALLNTIDHQLHRQLRAQLNPFFSSARIRRQEPAIKALVNKLCR
RLEELKNTGQPLNIEHALTCYTTDVITDYSMGDGYHYLDAPDFIPQWHGTLNGTAKTMVFIRPVAWALPLLLSLPEGVTA
WLNPGMELFFDFQRRCRKMIKRIVAAHYEKGDQGVQNGGFVNIFDDILRSDLPAKNKSETRLAQEMQVLVSAGAETTAKA
ITYILFYLLNDPETMAKLKAELETVGEDPALIQLEQLPYLTGVMLEGIRLSYGVSARLPRIAPYNALKFRDWTIPPGTPV
SMSCLLMHHNETVFPDSHRFKPERWLDPAERKRLEKYMVAFSKGSRQCIGMHLAKAEILLSVSTLLRRMDLELYETTVED
VAIKHEIFIPFPRMDSKGVRVLIKG*
>CYP682C3 Aspergillus clavatus
82% to CYP682C2
ACLA_003860
MELIRLLRSHPVAALALLGSGYLLGVILYRLYLSPIARFPGPKLAALTHLYEFYWDTICCGQFTFQIGRLHEKYGPIIRI
SPTELHVNDPTYYEVIYSRDSPRDKYGYYQRTLNAPLAILNAIDHYRHRQLRAHLNPFFSTLRIRKQEVAIKALVDKLCR
RLGEFQNSDTPVNIEYPLTCYTTDVITDYTMGDGYHYLDEPDFIPQWHGTLNGTAKTMVFIRPVAWALPFLLALPESVTA
WLNPGMELFFDFQRRCRRMISAIATAHRESGGKMAQDGGRLTIFDDILNSDLPARDKSEARLAQEMQVLVSAGAETTAKA
ITYILFYLLNDPPTMQKLKQELATLGPDPSLVQLEQLSYLTGVMLEGIRLSYGVTARLPRIAPYNALQFGDWTIPPGTPV
SMSCLLMHHDESIFPQSHLFKPERWTDPAERKRLEKYMVAFSKGSRQCIGIHLAKAEILLAVSTLLRRMDLELYETTVED
VQVKHDIFIPFARMDSKGVRVLIKG*
>CYP682C4 Aspergillus terreus
78% to CYP682C1 Aspergillus nidulans
ATEG_04990.1
MELLRLLLSHPYVTAAAVTVGYLLSAAVYRLWLCPIAHFPGPRLAALTVMYEFYWDTICCGQFTFHIGELHKKYGPIVRI
SPTELHVSDPDYYEVIYSRDSPRNKYNYYQRTFNAPLALITAEDHFRHRLIRSHMNPFFSTMRIRQQEPVLRALINKLCG
RLEEWKNTGKPLHIEHALTCYTTDVITDYTMGEGYHYLDEPDFIPQWYHTLTGTARTLVFIRPVAFLLPLLLAMPESVTA
WLNPGMELFFDFQRRCRKLIHKIATDHLEKGSHAVDQKGRLTLFDDVLSSDLPEQEKSEARLAQEMQILVSAGAETTAKA
MTYILFYLLDNPELLKKLKAELEPLGPDPALIQLEQLPYLTSVMLEGIRLSYGVTARLPRIAPYNALKYKDWTIPPGTPI
SMSCLLMHHDESVFPDSYRFDPERWTDLTERKRLEKYMVAFSKGSRQCIGMH (2)
LARAEILMVISTLLQRFEFELYETTVEDVRVKHDIFIPFTKLDSEGVRVLIKG
>CYP682D1 Aspergillus nidulans revised
MLEKGGFLRLFEGAFPASSKSQKLQKPSKSRMLHLVPYIFLAWVAYVVSL
VIYRLWLSPLAKFPGPKLAAATLWYETYYDAFKWGKYTFEIAKMHEKY
GPIVRISPHELHINDPDYYEVLYSRDSPRNKYEYFTK
QFPVAGSSIATVDHYHHRVIRSNMNPYFSITRARKQEPLVQALVNKLIER
LQAYKGTQTPINLQHAFTCFATDVVSDYSMGVGFHYLDEPDFIPDWSDTL
AWSVKNGVYLKAFPWSGALLNSLPPWLLSRIYPGMGLVFQFQDRCNRIVQ
RIMEEQKERGYEEVKNQFDHPTFFHDVLTSNLPKELKTPDRLAREVQAVI
GAGSETTGKMLTWTMYYLLENPDKMNALKEELNRLDPDQTATLVDFEKMP
YLTSVMLEGLRLSYGSSSRLQRIAPDRDLKFKEWSIPAGTPVGMTSVLIH
HNEEIFPDSHEFIPERWLDPEKRKYLEKYMVSFTKGSRQCVGMNLAKSEI
LLCLPHVVRKVNMELYETTRDDVTLAHDLFLGFAEEGSKGVRVLIR*
>CYP682D2 Aspergillus oryzae
GenEMBL
BAE55187.1
68% to 682D1
MVHPSVLVEALVMFRPIAQFLLFPPFCMFQFLFQPWIIALAGAGYLISLAVYRLWLSPLAKFPGPKLAAL
TLWYELYYDIYCEGQYTFQIIRMHEKYGPIVRISPWELHISDPDYYEVLYSRDSPRNKYEYYTRQFGLTK
TAMATVDHYHHRLLRSNMNPYFAMTRIRKLEPLIQGLVDKLCDRLREFKGTGTPVALQYPFTCFATDVVT
DYTMGAGFHYLDEPDFVPRWSRTLSGVAKSGVYIKPFPWLIKVFNALPESWLSWLNPEMDLTFHFQRRCR
EVIASIMEEQNANGYDKVKSQFSHPTFFHDVLNSNLPPEEKSPERLWQEVQVVVGAGAETTGKALTWTMF
YLLHSPDKLQKLREELNQLDPDRTATLLDFEKMPYLTSVILEGLRLSYGLSTRLQRVAPDRALQFREWSI
PAGTPVGMSSTLMHHDERIFPDSHKFIPERWLDLEQRKHLEKYMVAFTKGSRQCIGMNLARSEILLALPK
VLRELDFELYETTLEDVTLAHDMFLPFPKMDSKGVRVLIK
>CYP682D2 Aspergillus flavus
99% to CYP682D2 Aspergillus oryzae
AFL2G_00090
MFQFLFQPWIIALAGAGYLISLAVYRLWLSPLAKFPGPKLAALTLWYELYYDIYCEGQYTFQIIRMHEKYGPIVRISPWE
LHISDPDYYEVLYSRDSPRNKYEYYTRQFGLTKTAMATVDHYHHRLLRSNMNPYFAMTRIRKLEPLIQGLVDKLYDRLRE
FKGTGTPVALQYPFTCFATDVVTDYTMGAGFHYLDEPDFVPRWSRTLSGVAKSGVYIKPFPWLIKVFNALPESWLSWLNP
EMDLTFHFQRRCREVIASIMEEQNANGYDKVKSQFSHPTFFHDVLNSNLPPEEKSPERLWQEVQVVVGAGAETTGKALTW
TMFYLLHSPDKLQKLREELNQLDPDRTATLLDFEKMPYLTSVILEGLRLSYGLSTRLQRVAPDRALQFREWSIPAGTPVG
MSSTLMHHDERIFPDSHKFIPERWLDLEQRKHLEKYMVAFTKGSRQCIGMNLARSEILLALPKVLRELDFELYETTLEDV
TLAHDMFLPFPKMDSKGVRVLIK*
>CYP682D3 Uncinocarpus reesii
67% to CYP682D2 Aspergillus oryzae
UREG_00188.1
MDLRQFVSGQPVLAAAVAWLLYVISLVVYRLWFSPLSKFPGPKLAAATLWYEFYYDALCHGRYTFEIMKMHQKYGPIVRI
SPHELHIDDPEYYDVLFSRDSPRDKYEYYTRQFGTPMAAISTVEHAHHRLRRSNMNPYFSMGRIRKLEPTIQALVDKLCA
RFREFKGTGTPLVVQHVYTCFSTEVISGYTMGSGFNYLDEPDFVPHWCDTLSGIAKATVFFKQYPLLLHIMKALPENFVG
KMDPGMNLMFIFQRRCKVLIDSVIAEHAAPDYAEKRKSYDHPTFFHDILESNLPPEEKGPERLSQEIQGVIGAGSETVAK
TLSWLTYYLVANQDKLDKLLEELNRLDPDQTASFVDFEKMPYLTSVMLEGLRLSYGVSSRLQRVAPDRNLQYKEWSIPAG
TPVGMTSVMMHHNEDIFPDSHSFIPERWLDPAQRRYLEKYLVAFSKGSRQCVGINLARAELLLAIPKLFRQLKFELYETT
VEDVTLAHDLFLPFPKKGSKGVRVLVV
>CYP682D4 Coccidioides immitis
81% to CYP682D3 Uncinocarpus reesii
CIMG_00083.2
MSSFFILRLTVKSFWSVWWSREMEALPLIKEHPFLTATAAYLVYVTAVVVYRLWLSPLSKFPGPKLAAATRWYEFYYDAI
CHGKYTFEIIKMHEKYGPIVRISPHELHINDPEYYDVLYSRDSPRDKYSYYTGQFGTPMAAISTISHAHHRLRRSNMNPY
FSMARIRKLEPAIQILVDKLCNRLKEFKGTGVPIVVQYPYTCFSTDVISDYTMGTGFHYLDEPDFIPHWSETLSAIAKAT
VFFKPYPWLLYWLKALPEGLVGRVDPGMNLFFVFQRRCKVLINSVIREHSEPDYEEKRKSYDHPTFFHDILDSNLPPEEK
GPERLAQEIQGVIGAGSETVAKTLTWLTYYLLENKDKMDKLLEELNRLDPDRTATVVDLEKMPYLTSVMLEALRISYGVS
SRLQRICPDRDLQYKEWSIPAGTPVGMTSVMMHHNEDIFPDSYNFVPERWLDPDRRKYLERYLVAFSKGSRQCVGINLAR
AELLLAISKIFRELKFELFGTTREDVTLKHDLFLPFPKVGSKGVRVLVVD
>CYP682D5P Aspergillus oryzae
50% to CYP682D4 N-term part, 100% to CYP682D5P Aspergillus
flavus
VAGAFYVLWLALQRLWLSPIAHFPGPKLAALTMWYEFYYGSFLEGQYTFRIAEMHRKYGPIVRISPY
ELHIDDAEYYETLYSRDAPRDKSLHLTGMFGAPASAFGTVDHRRHRIRRQPMNPFFSQQRIRQLEPM
LRDMVDKLCDGLRAWKDRHTPLHMYHPFNAFTTDVVVEYTMGHSSHYLDDSDFSPQRSKTMQAIVNA
GIQFRQFRWFISLFELLPR
>CYP682D5P Aspergillus flavus
50% to CYP682D4 N-term part
AFL2G_01379
VAGAFYVLWLALQRLWLSPIAHFPGPKLAALTMWYEFYYGSFLEGQYTFRIAEMHRKYGPIVRISPY
ELHIDDAEYYETLYSRDAPRDKSLHLTGMFGAPASAFGTVDHRRHRIRRQPMNPFFSQQRIRQLEPM
LRDMVDKLCDGLRAWKDRHTPLHMYHPFNAFTTDVVVEYTMGHSSHYLDDSDFSPQRSKTMQAIVNA
GIQFRQFRWFISLFELLPR
>CYP682D6 Aspergillus terreus
63% to 682D2
ATEG_08919.1 revised
MKEILLLYAQAAGLVGAAYFLVLAIYRLWLSPIAHFPGPKLAALTLWYEFYYDTILHGQFTFEIARMHRRY
(1)
GPIVRISPYELHIDDPEYYEVLYSRDSPRNKYEYYVRQFGQPKAAFSAVEHSRHRLLRASMNPFFSLTRIRRHESRIKALADK
LTQRLNEFQNTGRPMVIQHAYTCFTTDIVSEYVAGQDFHYLDSPDFMPQWCETLSGIAKAGVFFKPFPWLHSVMKCLPQS
WVSRVDAGMGLFFSFQQRCASLIQSITDSENNQPGKSANNTRAHTAFFHEVLKSDLPPSEKSAERLAQEMLIVVAAGAET
TAKALTWITFHLLNKPELLQRLLDELQRLDPNQTASLLQLEQMPYL (0)
NGVILEGLR (2)
LSYGISSRLPRIAPDRALHYKEWTIPPG (0)
TPVGMTSVFMHHNESIFPDSHRFMPERWLDLQTRKHL
EKYMVAFSKGSRQCIGMNLAKSEMLLAVSKVFREVKFELFETTVEDVTMA
HELFLPFPKVGSKGVRVIVRS*
>CYP682E1 Aspergillus nidulans
AACD01000079.1 Aspergillus nidulans FGSC A4 revised 7/18/07
MLSLDLVFSFPAWALLLVLTLLYTLYLA
TTRLLLSPIR
HIPGPTLAALSFWPEFYYDVVQRGQYFRQIDKMHQTYGPLVRINPFEIHI
QDPSFYPVLYTGPTRRRHKWLWAARMFGNNTSAFATVRHEHHRLRRSALN
PLFSKSAIQRLTPHLQHTLARLCSRLDGFAFTRQDVDLGIGLTAFAADVI
TEYCFGQSLELIGKDNFGKEWIDMVSAPSELGHLVKQCPWILVVCKWAPKALVRALLPGVALLFQIQE
(0)
RMSAQIQPLVDRAAAVDKPA
DPLTVFDFLLSSTLPQHEKTVDRLKGEGQTLIGAGTLTTGNALKTIIFHVLNDPDI
FRKLRAEVDGALENMDILSMSDTAYLERLPYLSACIKEGLRISYGVTHRL
QLIAEEPLIYSGVTIPAGTPVGMTSIFMHDNPVVFPQPREFRPERWFEAD
FETVQAMNRHFVPFSKGSRMCLGMNLAYAEIYLVLAVLFRRYEISLSGVT
REDIEMAHDFFDPAPKEGARGLIVQLQKRG*
>CYP682F1 Aspergillus niger
XM_001397274
43% to
682C2, 42% to 682D2, 41% to 682D1
35% to
cytochrome P450 Myrothecium roridum tri4 gene CYP58A2
60% to
DQ054596 mid region fragment of Aspergillus ochraceus in
ochratoxin
synthesis
MSIDTLLYTSLAVGAVYLASVALYELYWSPLAHIPGPKLAACTR
LYEFFYDVVCGGQYTFKIADLHKQYGPIIRISPREIHIHDPNYYETLYATNSPRNKDP
WFTAHFGVDESAFSTLDYRLHRSRRAMIAPFFAKARMDGAQPLIKANLAKLIRHLDAH
ASSQSVLKVEVAYNSFTGDVITGYTSYRSFEYLETTDMVPIWSETVRNLVESGMLSRH
LPGFFPLLAWAGSRCIAAVYPKLLPVIAFRMKCAQEVNFMWTNSEEGKKEAIQSGCSE
PALFPELVSRASSAPDITEERLLHEFITIVAAGTETTAHTMTVCTFHIAHNQSILDKL
REELDNRFHSNADMDLQTLEQLPYLTGIIYEGLRLSYGLSHRLQRISPIDPLKYKDIA
IPPNTPVGMSSALMHHDESIFPQSHEFIPERWTDPNDRRRLNKYMVSFSKGSRQCIGM
NLAFAELYLGIATLFRRYDMKLHDTTLDDVQLHGDKMLPRAKNGSKGVRVTLRRAQSVG
>CYP682F2 Aspergillus ochraceus
DQ054596
P450 in the
ochratoxin biosynthesis pathway
60% to
CYP682F1 (mid region)
EVQRIQSLIQSKLQKLNTRLSEYAHSGEPLKVDVAFNCFTADII
TSYTSFRAFNYLDDPEMVPIWSETIKNLVEIGMIARHLPGFFPLLASMGMKWVKRVYP
KLLPVIAFRMKCAQEVNFMWENEEEAKLDFEKNRLSQEPALFQEMVAKAPDT
>CYP682G1 Aspergillus niger
e_gw1.2.437.1|Aspni1
44% to CYP682B1
MTLFGELSYLSLASITLTVFLAYVIGCIVYRLYLSPIAAFPGPPLAAVTWYYEFYYDAICGGRYIFKIKDMHKRYGPIVR
INPEELHIETSTFYDELYAPGGKKRRNLNPQFEHQFGAPNSTFATVDHDLHRMRRSALSPFFSKASVRRLQPVIWEKVDK
LLRRLDEFKNTGQPVRMDIAYAAFTNDVDVIMEYSFNHSRDRLQKPDFGEPAQEAVLAMSKVVHWMKHYHWLIYLAQLIP
PWIVSWISPTLQSFTRENVAQVHQIMNDKDRLGVGKQSKTIFHDLLANPDLPVSEKSVEQLGQEAKILVAGGTETTSWTL
SVITYYLLSQPHTLSRLRAELIASIPDPTASVGIEVLEHLPYLTAVIQEGLRLSYGSVGRLARVSPDEAVTFHDEKRAKD
WIIPPGTPMSMNSVFVHHDPTIFPEPSKFSPERWIEAEKEGKRLNRYLVSFTKGSRSCVGINLAYAELYICVSRIFRLYS
CTEDEMSGKGGWLELFETSNEDVEFATDMFIPATRQGSKGVRMLVKGI*
>CYP682H1 Mgr071 Mycosphaerella graminicola
44% to CYP682B1 N-term from JGI model e_gw1.2.1462.1|Mycgr3
MPNLELWTALSYFT
MAEIVVSGLLLYFFTLAVYRLYFSPLAKIPGPKLAALTLWYEFYYDVVLKGQYTWKIGEMHEKYGPIVRINPFEIHINDP
DYYNEIYAGPTRRREKWAWSAAMFGNSSSHFGTIPHELHRRRRAPLNPFFSRASVTRLEPMLRQVVEDLSTRLEQFRESQ
KPVNLRHAFAAVTMDVVTDYAFGTSYKCLEQPDFAPMWAEAIDSVSEQSHMNKQFPIVLQMMRMMPLWVVERTAPDVMRL
IKFQMDMATQVSLQMSGKSADNKVSDHPTIFHELLQPGALPESEQTLPHLVNEAQSIVAAGQVTTTHYLNTTAYHILARE
DVLKRLKAELKEVMSDGSLPSWQALEQLPYLSAVVLEGYRMSHGPVHRLQRVAPDEDLVYKDYVLPPGTPVGMTSIFIHE
NPSLFPDPRAFKPERWLEPGAKERLSNYLVNFSKGTRGCLGMYLAQAEIYLTLAAVFGRFDMEIFETTRADIDVAHDFFN
PQPRKGSVGLRVLVK
>CYP682J1 Uncinocarpus reesii
40% CYP682B1 Aspergillus nidulans
top hits are all CYP682s and CYP58s
UREG_01137.1 missing the C-term, added back
MQFSSGMLVPFGLLLCGYVVWLVLDRLFWSPLAKFPGPRLAALTNWYEFYYDVILQGKFTAHIQDLHKQYGHIVRITPTE
LHVDDPEFYEQLYSRNGRRDKYAYFSGRFGYASDTFSTVHHDLHRLRRKPLGPMFSTQKISEFQPVIRAKIEKLCQKLTE
YHDGKIVTLNRAWMALTTDIITEYAFAKSYDQLDSPNFRDTLHESLVAIYVTGHFALHFPIVFPVLDALPEWLVLKMQPD
LVSVVGMRKDLARRVNDIRNGVNDSHKTVKHRTIFHEVLNSDLPEGQKTDARLGDEAQLIVAAGLITTSWALTVASFHII
SDRAILTKLRREVNDAQSGSDDPLDWHVLEQLPYLNGCVREAIRLAHGITTRNPRLAPDSELKCGDWVIPRNTPVSMTNV
DTLMNPTIFPNPEKFIPERWIKDPSLDRYFVAFGKGSRQCMGIN
(2)
LAMAELYSAIATVFTRFTFELYDTTHSDIVMKHAYLVPYANWDSKGVRALVHPADHAQR*
>CYP682J2 Coccidioides immitis
85% to CYP682J1 Uncinocarpus reesii
CIMG_01197.2 revised
METPSWAFLSLGFTLLTAYIGWLVLSR
LFWSPLARFPGPRLAALTNWYEFYYDVILQGKFTEHIQDLHKQYGRIVRITP
SELHVDDPEFYEQLYSRNGRRDKYAYFSGRFGYASDCFSTIHHDLHRLRRKPLGPMFSTQKISEFQPVIRAKVDKLCQKL
SEYSDGKVITLNRAWMALTTDIITEYAFAKSYDQLDSPGFRETLHEALVAIYVTGHFALHFPVVFPILDALPEWLVLKMQ
PDLVSVVGMRKDLARRVNNIRNGVNDSYKTVKHRTIFHEVLNSDLPDDQKSDARLGDEAQLIVAAGLITTSWALSVASFH
IITDSSVSKRLRDEVNLAQSRSEGPLDWRTLEQLPYLNGCIREAIRLAHGITTRNPRLVPDSELVYGEWVIPRNTPVSMT
NVDTLMNPEIFPDPEKFVPERWIEDPTLDRYFVAFGKGSRQCMGIN
(2)
LAMAELYTAIAIVFSRFTFELHETSHSDIVMKHAYLVPYPRWDSKGVRAIVHSVNQP*
>CYP682K1 Uncinocarpus reesii
44% to 682D2, 46% to 682D1
UREG_06063.1
MVKVLTMACILAIAYVVGVVVYRLYFSPLARFPGPKLAAATLWYEFYYDVILKGQYTFKIKDLHQKYGPIIRISPY
ELHINDPEYYSTLYSHSSPKDKYYYYVKPFDFPRSSFGTESAQVHRFRRGAMNPFFSRGKVLQHEGLVQELVRKFCDRIE
GFGKTSQIVPLSLGFTCLTTDLITSFVLKRSYRFLEATDWNPHWGQTLRDASELGMMSRQVTWMLPILKSLPRAWAEALN
PGLVLFFSLVQRTYQRIAEVEQQRDMAEKGNACSERGYTLIDQILDSKLPDDEKTPERLAEEIRSAIGAGTETTSNALTV
TVYHILRDPSKTQRLRQELEGIEPNPDREIKLRELEQLPYL (0)
SSCILEGLR (2)
LSYGVSTRLQRKMDNQVITYKEYVIPPG (0)
AAIGMTSILQHHDESIFPDSYSYVPERWLGEEKRKRLERYLVSFSKGSRRCIGMS
(2)
LAMAQLYITIASMFRRFNFELYGTTRADIEVRHDLFIPRPKNLKT
LGLRATAERREPVMTRH*
>CYP682K2 Coccidioides immitis
68% to CYP682K1
CIMG_09894.2 revised
MAYTFTVARMSIIGYIVGTLVYRLYFSPLSKIPGSKLAAATLWYEFYYDVILGGQYTFKIKELHQKH
(1)
GPIIRISPYEVHIDDPEYYHTLYSHRCPRDKCDYHVKPFNLPKSSFGTESARVHRLRR
GAMNPFFSRGFVLKHESLVQDLVQKFCRRVEEFARDEEIVPLSLGFTCLT
()
DVITSFVVNRSYRYLEASDW
HPHWGQTLKDASKLSVITKQVAWTLPIPKCFPQSWAKALNPGLALFFDLTQRTHRRILEVLKEREQERGVSGPGRRKTLI
DQLLDSKLPQEEKSMERLAAEIRSAIGAGTETTSNSMTYHLLANPQKLQRLRDELLKLGPGREANLCELEQLPYL
(0)
SSCILEGLR
LSYGISTRLQRKSDHTEIVYKAYRISPG
TAVGM
TSVLQHHDEAIFPDSYGYVPERWLNTEERKRLEKYLVTFSKGPQRCIGMS
(2)
LALAELYLTVTNIFRKFNLELHNTGRNDIDIRYDLFIPRPKNLKTAGVQVRVKGLDN*
>CYP682K3 Histoplasma capsulatum G217B
60% to CYP682K1 Uncinocarpus reesii
HCB05195.1
MLNEAGHLTFTQGVLVSICSFFIIYLTGGVIYRLYLSPLAKFPGPKLAAATLWYEFYYDAVRRGRYTFKIKELHQKYGPI
VRISPYELHIDDPDYYRVLYSYSSPRDKYPYYLKPFGFPLSAFGTENHYQHRRRRGALNPLFCNRKVAQREGLVHQLVHR
LCEYLEQFRVTGKTVSLSLGYTCLATDLIVSYVLDENQQWLDAPEWLPHWRWALRTLSEMVMVSRQVTWLLEILKHFPRA
WVASSNPGLGLFFELEERFRRKIDEIQIDRGRISQRAETEISKGYTLIDQILDSNLEVEEKTPERILQEIRSTTTAGIET
TSNALTVITYHLLDNPDKLQKLQNELSILEDGGNSEQQVHELGKLPYLTSVILEGLRLSYGVSTRLQRKSPEQAIQYKNY
CIPPGTPVGMTSVLMHHNEAIFPDSCKFVPERWLDLQERKRLERYLVSFGKGSRRCVGQRLAETTLLIAIATIFRKFELQ
LWGTLKNDIEISHDLFVPRPKNTKSIGLQVRVLKKY
>CYP682L1P Coccidioides immitis
pseudogene
44% to CYP682A1 Aspergillus nidulans
45% to CYP5095A2 A. niger
CIMG_08072.2
MALQHWYHSCSETHREGVIAAALAIW
ILYLVSLAVYRLYFSPLAKFPGPKLAALTRWYEAYYEIVKIGQYSFKVDELHDKF
GPIVRVTPDEVHIRDAQFYDQM
YAKNPRVSKPG*NKIFGTEAAAFSTIDSATHRRRRGALNPM
FSRRAILVLEPVVREYVALLCKRVAEYATKSKPLAITVAHSAYTGDVIV
EYSFGFSYRHLENPNFESFHDALMVMGLSAHLASQFSWFLP (0)
QLVNSLPDWFVEKIQPDPASLLRLRR (0)
DHWDLIGQIIRGEEAVSKVKLHPTIFHEILRSSLPPEEKSQQRLLDEAQIVVAAG
VGTTAYTL &
DVGTFHILNTPHIYQRLHKEVADAFPDKNVIPSLLELEKLPYMKTCIQESLRLSYGLSG*N
PRAHDKPLQYGKWTIPANTTITMSIVDVHHDEAI &
FPDSHSFIPERWLDNPKTSDGTPLERYLVAFGRGPRACLGLS (2)
LARAELNYAFGTVFRRFEFELYETDITDVKYKHDFFNPPVKMDSKGVRLLVSEVSD
>CYP682M1 Fusarium oxysporum
42% to CYP682H1
FOXG_14591
MENLQLNARTLLTVAASLIALRITYTVVYRLYLSPLAKIPGPRLAALTFFYEFYYDVVKRGKFLWKIQELHRQYGPIVRI
NPYEVHINDDSFYDEIYASGPHHPRNKIRFMSTHDESMFDSYAAETHRVRRAALSGSFSKQSIRALEPQILQTIHQLAGR
MSSLRESGEVVNFKALYSGLTMDVIAQYCFGESMDNMKQDQFGKELLDFFHEMPQAHPIGRMFPWLFDIIQKIPISYLAK
LDPKLQPLADYDKKISGQISDVLAKEKKDGIRTVFHEMRDSKQLPEADKTLERFKSEAAIFLGAGTETTAAALTTLSFHL
TENPDMLTTLRKELETVTADASSPITVAKLEPLPYLLYKKV (0)
EGIRLSFGVPGRLPRYAPTEDLVYAGYKLPRG (0)
TRMSSSSYLIDTNEEHYPDPFKFDPERWMHGKTSLSRH
FVPFCRGSRQCIGMNLAYAELYLTVATIFSRFDLELVGTTKRDVEIAHDFFVGMPPLDSKGVMVRVVKDRSE*
>CYP682N1 Aspergillus clavatus
39% to CYP682M1, 42% to CYP682G1, 41% to
CYP58E1
some overlap between CYP58 and CYP682 families
ACLA_061270
MMSSDLSSFLIHCTFKDVLLGGISLYLVYGILLCIYRLTLH
PLAQFPGPKLAAATFWYEFYYDLFPHKLRYLWKIEEMHKKYGPIVRINPIHLHINDPNYLDEIYAGGKRKRNRDPWYYRS
ESNGPLGWSVFQTVDHDVHRMRRAALNRFFSKRSVQEHEQMIIDKIEILCGRFAEACRTGDIVSLTFACGALTMDVISAY
AFGAETDNLTRQDFAAEYLEAYSKLSQLGPVGRQFPWLAKACLTLIPSSLVHRISPAAALIPRNRLFFRGIIEESVRQQE
AGKGNKGKSIFQDILRSNLPPSEKAPARLAAEANLLVIAGTETTARALSLVLFHILDNPQTVLQLREELAPLMPHPDSRV
SVAALEALRFFPAVITEGIRLSHVVSSRMPRYAPEETLRYGKWIIPAGARVMQSHYLHHMNPDIFPDPYTFNPHRWLDNP
ELKQNYFMGFGKGSRICLGINLVHAELYLTIARLMTRFDMRLHETIRERDVDVKRDCIIGLPSLEGQGIRVRITQDRAG*
>CYP682-un1 Aspergillus oryzae
pseudogene 99% to CYP682-un1 Aspergillus flavus
AFL2G_06952
DDDRSTLATLEQLPYLTAVVQEGLR
LCDPVTHRISRQFPDQPLQCRGIFIPANSTVGMTAMLTHLNEKIFPEPRVFRPERW
LGSDGKRLERYLVPFNRGTRSCLGMNLARAELVLILAAVFRQFDFDVSGVNRERDID
VSRDYILGAQARDTPGILVTVKGC*
>CYP682-un1 Aspergillus flavus
pseudogene 47% to CYP682H1
AFL2G_06952
DDDRSTLATLEQLPYLTAVVQEGLR
LCDPVTHRISRQFPDQPLQCRGIFIPANSTVGMTAMLTHLNEKIFPEPRVFRPERW
LGSDGKRLERYLVPFNRGTRSCLGMNLARAELVLILAAVFRQFDFDVSGVNRERDID
VSRDYILGAQARDTPGILVAVKGC*
>CYP682-un2 Aspergillus terreus
41% to CYP682C2 Neosartorya fischeri C-term
fragment
ATEG_06280.1
TPISMNIWNTHYNKDFFPGPTEFWPERWMGEGTRELEKYLVPFGSGSRMCTGQNLSIAEQV
LTIATLFRNYELELYQTTKKNVVMASYCMISLPGSESPGIQVKVRKTVQ
>CYP682-un3 Mycosphaerella fijiensis
fgenesh1_pg.C_scaffold_32000094
45% to CYP682A1 Aspergillus nidulans
45% to CYP682L1P Coccidioides immitis
MSSISIAGIAILGYISSLTIYRLYLSPLAKFPGPKLAALTKWYEAYYEIVLNGKFSFHIEDLHRKY
(1)
GPIVRITPFEIHIQDPSSWESLYVKHNKSSKYEWTAGRFGNESSVFTTSDPTLHRIRRGALNNM
(2)
FSRRAILNFEPVVSRYVDIFCNGLEKFRQTGSICN
MTEAFSAFAGDVVTDYCFGFSYEHLAIEGFTHSFHDAFMAVSAFGHVALQFPWVHP
(0)
LLNSLPDSWNAAMNPPLAELLGLQK
(0)
IAQVKEDTARNEKMPEHPTIFHTLLNDKSLPDSEKTNLRFAEEAQLLLGAGIETTSWSLCQTFFYVLSQPDVLS
KLKAELYEAIPNAAQLDAFDYTKLENLPYLARCIK RRICLSLSLSARKP*VLTQAFVWRDP*
TCPRLVVPSGTANSMTNARCALNNDL &
FPEADKFKPERWLGDSPKAPDGSPLERYFVAFGKGPRSCLGIN
(2)
LAWMELFKVVGTIMRKFQLELYETDITDVLLEHDFFLPSPRLDSKGIRVKVVGIES*
>CYP683A1 Aspergillus nidulans AN9030.1
poor match 53 clan
MIFAQLPTLTAQVVHFMQSRLLLCITAFVVLCIIHTFLYAFLLSPVRHVP
GPWWARVSRIPLLYATWQRRRSRYASDLLRKYGRLVVIAPDQIHTSDETA
MKTIYAKSSIKTRFYAGMGSWKGVKSTLGFVDYRSAAPTRNNLIQCFQNR
NLDTLVDSMACHITEFCDMLKPKVSNNKAVDGVVIFRLLALDIVTDILWG
EKDTLLSKGFDQTPVFLRRFHAFSSWNALKSFIPGLDTYVRFLGSSNMRQ
LRADCNDMDVTAREALDRWHARPEERHQKDVLSMLQAMSNSDDPTKRIPS
EHIPAYMVEMLAAGSSTTSHTAAFACDQLARYPKALEALQKELIEAFPDK
ENIDERKMLSLRYLEGVIYETMRLYPMIPGPLERHLGEWIEVDGMKVGPG
VIASTAAYDQGRLPDVFPEPEKWNPERWLQATDRMKLNWIPFGHGCRSCP
GSNLALTELKYILGTLFRRFRVQLPEDYPNEPLELADVFAAGSKTGHCWL
EFEEMPK*
>CYP684A1 Aspergillus nidulans
AACD01000005.1 revised
MQPGLSFLVGNWPSVVVLLGFAYFLTLAYGVRKNP
LSSLPGPQLTKWTDLLLKFYTVTGQRPRYVHALHQKYGPVVRISPSIVDI
SDVSASRDIHRIASPFLKAPFYKMLVRKDGESLFSTTDPEYHRRHRRLLS
SPLSDTNLRTVEPLVKARIRLAISRIREEALSPRGVADIYKWFFFMATDI
IGELSFGDSFRMLEIGKKNQYISDLETVAKIGGIRANFPWIISIGQILPL
SIFREVVVSTDRILEYANQSVERYKRHLAMNPNQPKPTLFTKLYDASLHK
EGDGECLSDREIRNDAQSFIVAGSDTTANTLTYLVWSVLKDRSIQEKLVE
ELDVL (0)
EELSDVHLRELQYMNQVINEALRLYPAVPSGLP
RVVPDKGSTLAGHWLPGGATVTTQLYSLHRDEEVFEEPER (2)
FDPSRWENPTKAMKDAYMPFGAGSRN (1)
CIGLHLAKMELRLATAYFFRSFPRARISAREDMNDGDMEMMLYFLLSPKGKRCLVEVN*
>CYP684A2 old name = CYP5041A2 Aspergillus oryzae
AP007164.1e 51% to
fgenesh1_pg.scaffold_8000032
Fifth P450 of six
on this accession
CDS complement(join(1693125..1693300,1693352..1693428,
1693479..1694095,1694146..1694531,1694582..1694720,
1694773..1694844))
MDSGFIRDNIPAIASIAVLVYVLSV (0)
VYRSQRSHLSYLP
GPWYTKFTDLPLRYKVVTGQRPRYVHALHDKY (1)
GPVVRIGPDEVDVSDISGAREIHRIGSGFLKS
PWYSLLNRKDTQSIFTTTDPKFHNAHRRLLSSPMSELSLKSMEPLIDARVRLTIQKMQ
EEMKTRGVADVYKWWFFMATDIIGEITFGESFRMLEKGK (0)
KNQYVKDIEMISVIGGIRA
SFPILVKLATLLPLPIFKEVNASGNRVFGYATESINRYKRLLAENPENPKPTVFTKLY
NAGEEGLPDNEIRDDAQSFIVAGSDTTANTLTYLVWAVCRDPQIKKKLVDELAEIRDD
FTDEDLRSLPYLNQVINEALRLYPAVPSALPRSVPPKGTTMGGHWIPGGSTVSTQLYS
LHRDPVAYPDPEK (2)
FEPSRWASPTKLMKDAFMPFGAGSRN (1)
CIGLHLAKIELRLATGYFFRYFPNAKLSSKYDFNDNDMEQMLFFLMSPKGKRCLLEV
>CYP684A2 Aspergillus flavus
100% to CYP684A2 Aspergillus oryzae
AFL2G_06246
MDSGFIRDNIPAIASIAVLVYVLSVVYRSQRSHLSYLPGPWYTKFTDLPLRYKVVTGQRPRYVHALHDKYGPVVRIGPDE
VDVSDISGAREIHRIGSGFLKSPWYSLLNRKDTQSIFTTTDPKFHNAHRRLLSSPMSELSLKSMEPLIDARVRLTIQKMQ
EEMKTRGVADVYKWWFFMATDIIGEITFGESFRMLEKGKKNQYVKDIEMISVIGGIRASFPILVKLATLLPLPIFKEVNA
SGNRVFGYATESINRYKRLLAENPENPKPTVFTKLYNAGEEGLPDNEIRDDAQSFIVAGSDTTANTLTYLVWAVCRDPQI
KKKLVDELAEIRDDFTDEDLRSLPYLNQVINEALRLYPAVPSALPRSVPPKGTTMGGHWIPGGSTVSTQLYSLHRDPVAY
PDPEKFEPSRWASPTKLMKDAFMPFGAGSRNCIGLHLAKIELRLATGYFFRYFPNAKLSSKYDFNDNDMEQMLFFLMSPK
GKRCLLEV
>CYP684A3 Aspergillus niger
e_gw1.8.1151.1|Aspni1
66% to CYP684A2
NPLSSIPGPFLCKWTDIFVRYQTVTGNRPRYVQALHKIYGPVVRVGPNAVDIAKIAEAREIHRIGSGFLKSPVYELLKHD
NAKSIFSTTDPKFHSKHRRLLSSPFADANLHSLEPLIEARIRLTMQRMREEMTTRKVADVQKWFFFMSSDIIGELSFGDS
FRMLEQGKKDQHIKDLEIAALVGESRVAFPFIFRLAEFLPLPILREANKSRNRFGNYADECVNRYKRLLAASPEDVKPTL
FTKLYNAGKEGLSDAEIRDDASDLIIAGSDTTANTLTYLTWAVCKAPVIRQALVAEVATLPERFSDKDVQSLSYLNQVID
EALRLYPAVPCALPRVVPPQGATFSDHWVPGGSTVTTQIWSLHRDPVAFPEPEKFDPSRWASPTKEMKDAFMPFGAGTRN
CLGLHLARIELRLATAHFFRQFPRSEVSSREGMSDEDMEQVLHFLLSTKGHRCLLEV
>CYP684A4 Aspergillus terreus
53% to CYP684A2 Aspergillus flavus
ATEG_03444.1
MAYIQASSTQAVVVLLLVLVLTKIYRVYTGPLAHLPGPAISKWTGLVLQKHLFAGNRPRYVQKLHQLYGPIVRISPDELD
VSDSAAAKSIHRVASRFYKGRFYEHIGHRSPKTLFSSTDPQFHAYRRRLLGGAMSETSIRQHEPTVAQKVKLCVDQMARE
AERRGCIDVFKWWCFLATDTIGELSFGESFRMLEKGEKSQYSRDLELVSTLMIIRTTFPFLSRVAEYVPLPYFKQAAQSG
KRMFGYASESIQRYKKHVEM
YGDGVRPTLFTKLITKGHQEGSLTEAEIRLEAGGYIVAGSDTSAISLTYLVWAVCKN
PLIRDSLVAEVATLPEDFTDDDVRALPYTRRVIDETLRLYPAVPGALPRAVPPEGATLVD
HFIPGGVTVSTQVYSLHRDPKIFPDPDR (2)
FDPDRWIDPTTEMRDSFMPFGGGSR (1)
TCIGMHLARMELRLATAHFFRRFTSPTVSTKEGFTDDDMYQHMYFLVSPKGHRCLIDV*
>CYP684A5P Aspergillus terreus
54% to CYP684A2
50% to CYP684A4 Aspergillus terreus
gc boundary at DPDR, bad boundary at HLHM
ATEG_08902.1
(seq gap upstream)
LAGRRAKYVHFLHLHM (?)
XPIVRLSPGEVSVSDISASREIHRVGGQFLKSPWYLTLTAKGVENLFNTIDPQFH
GRHRRLLSMPMSDTSLRGVEPLVNSKIQFTIQRMKGDIERTGVVDIYKWWILMASDIIGELSFGESLGLLEIGMESPFIT
DLKAVGTMEALNTTFPCLVNLASIFPLPFIPNVVSGGRRMVQYADEALARYKNHLVTNAENPKVSLFTRIYKATEDGLTD
AEVRDDALSYIIAGSDTTATSLTYLVWAVCRSPRIKQALLEEVNSLPDGFNDQDTRRLSFLGQVINETLRYAAAPSGLLRVVPSGGRVLAGHFVPAGVTVSTQAYSLHRDPTIFPDPDS (2)
FNPSRWENATKLMKDAFMPFGGGSRICIGLHLALREIRLATCYFFRTFPHAEVFDEKTTDADMEQVIYFLMAPKGKRCFIKSPGSV
>CYP684A6 Aspergillus terreus
54% to CYP684A2
ATEG_05259.1
MGFLTLFQSISLVLFL (0)
RLLYRRFNGPLAHLPGPEISRWTGLLGTIYWFRGQKPNYVHYLHEKY
(1)
GPIVRVTPEEVDICDITAAKEIHKTGGRFLKSNFYHALAPPGTESVFSTTDPAFHSAHRRLLAMPISDSSLTGFE
QVIAGKVHLAVRRMGEEMRSRGAMDVFKWWLFMATDVIGELSFGESFRMLESGQKNQYILDLEQISSLAPVRTTFPLLVQ
LGSLLPLPVFRRVAAAGQRLIDYAQQSIDRYARLVEGSGVSAPPPTLFMKLYNAGKDGLSTTEIRNEARTYIVAGSDTTA
ISLTYLVYAVCRDERVHARLVDEVAALPENFDDRMMRELPYLNWVINEALRLYTAVPFGLPRTVPAEGAEFLGYRLPGGV
IVSTQSYSLHRDGEIFPEPDR (2)
FYPERWETVTKEMKEASMPFGKGAR (1)
ACIGIHLARRELRLATVLFFRAFPQARISTREGMGEDD
MEMKSFFLMAPKGHRCLIEA*
>CYP684B1 old name = CYP5041A1
Nectria haematococca
fgenesh1_pg.scaffold_8000032
Necha1/scaffold_8:72793-74540
39% to 62B1 Fusarium graminearum, 40% to fgenesh1_pg.scaffold_24000105
incorrect last exon and missing exon 3
51% to Aspergillus oryzae AP007164.1e (in CYP53 clan part D)
72793 MIHTLEGLLCRSHLAIFLALVGLIYLVSI (0) 72879
72926
LVYGRYFQLLARLP (1) 72967
73013
GPELSRYTDIILKYHWLRGTRAQYVHYLHKHY 73108 (1)
73162
GPIVRVGPNEVDISDISAVKEIHSVKGGYKKSRFYELLVPGT 73287
73285
TTNVFNSTDTEFHRRHRRILSSPLSESSIKTVELAVDQKVKLVISKMAEE 73434
73435
MAARQVTDVAKMWLFMATDIISELSFGESFGMLEAGK 73545 (0)
73603
KNQYIEDLEGLAARGPILTTFPTLIAIARKIPLPVLQKTAAAAARLRNYA 73752
73753
QHAVLRYKRDFASNPAAAKPMLFKKLFEAGEDGLSDEEIRAEAQAYIVAG 73902
73903
SDTTATTLTYLIWSVCRDMRVKQTLVSELNKLPADFDDNDLRSLPYLNAV 74052
74053
IDETLRLYAAAPSALPRVVPHGGSTLAGYYLAQDTVVSTQAWTLHRDLTL 74202
74203
FPNPERFDPSRWLEATKEMRDGVMPFGGGAR (1) 74295
74361
VCIGKHLARMELRLGTARFFRAFPSAVVSISEGMSDQDMIPKVFFLLAPNG 74513
74514 GRCLIEAR*
74540
>CYP684B2
Fusarium oxysporum
68% to
CYP684B1 Nectria haematococca
FOXG_14626
MDSQLEGGFLRLETTGLFLLFLCTLYLLYH
(0)
VTCTIFFNPLSRLP
(1)
GPWISCWTDAILKYHWLKGTRAQYVHRLHQRYGPVVRVGPHEVDISD
ITAVKEIHRVKDGYRKAPFYQNLVPNTNNLFNTLDLEYHRHHRRLLSSPLSESSLKSVEPTVDDYVKTAIASMKREMDER
GTADVAKFWLFMATDIIVELSFGESFGILKHGKKNQYIKDLEGLAAKGSIRSTFPTLTTIATKLPLPIFKETAAAAQRIR
DYSAEAVARYKRYVANNPAAAKPTLFKKLFEAGEAGLSDEEIRAEAHAYIVAGSDTTATTLTYLVYSVCCRGDVRQKLVK
ELMELPDDFGHSDLRDLLHLNNVIDETLRLYAAAPSALPRVVPARGAHLAGYFIPGDTVVSTQAWTLHRDPDVFPNPETW
DPARWEKGSKLMHDAVMPFGGGSRVCIGKHLARMELRLATARFFRAFPNACVSSIEGMSQDDMELRAYFLLTPKGGRCLI
QLD*
>CYP684B2
Fusarium verticillioides
86% to CYP684B2 Fusarium
oxysporum = ortholog
FVEG_13449
MDSQLGGGYLSLEATGHFVLLLCIVYLLCN
(0)
VTFTIFFNPLSRLP (1)
GPWISCWSDMIAKYHWLKGTRAQYVHDLHQQY
(1)
GPVVRIGPHEVDISD
MTAVKEIHRVKDGYKKAAFYKNLVPNTNNLFNTLDVEFHRHHRRLLSS
PLSESSLKAVEPTVDAYVKMAIDSMKREMDERGAADVAKFWLFMATDIIVEL
SFGESFGILEHGKKSQYIKDLEGLAAKGSIRSTFPTLISLATKLPLPVFK
ETVAAAQRIKDYSAEAVARYKTNFTNNPAAAKPMLFRKLFEAGEDGLSDE
EIRAEAQAYIVAGSDTTATTLTYLIYSVCSYVDVQQKLVKELMELPDDFG
HSDLRDLPYLNNVIDETLRLYAAVPAALPRVVPNGGAHLAGYFIPGDTVV
STQAWTLHRDPRVFPDPEKWDPSRWEKGSKMMHDAVMPFGGGSRVCIGKH
LARMELRLAMARFFRAFPKAKVSSIEGMSEEDMELRAYFLLSPKGGRCLIQLE*
>CYP684C1 Aspergillus niger
fgenesh1_pg.C_scaffold_11000386|Aspni1
44% to CYP684A2
MESLAQLPGIFLPLAGCVLALSLSALLAVGPIVRVTPTEVDICDLPAVREIHRVRGGYLKSEWYKSLTPPGVTSLLTLIE
PTQYSEWRRLLAGPLSDTSLGKVEPMVTNHVHATIDRIASDLQSQGVSDLYKWWTYMATDVVSELSFGEPIGLLARPKET
AWVMDYLDKVGIMHAWRTTFPFVFVLGRFMPVHPFKHAIQAIGLLGKWARRSIQQYRQHIQEQPESPKPTLFTKLFKADK
FDDFQLTYLAGSYITAGSHTTAVTLLYLIYAICRDNEIRQKLLAEIRTLPENFRHDELRHLPYLNQVITETLRKYAVVSS
ALPRVVPAGGATLAGYYLPGGTTVSTQAYTLHRNEAIFPNPEKYKPNPKYSYLSMLSVWLIECRFDPSRWESPTQEMKDA
YMPFGGASRMCIGNSLALMEIRLTTTLFLRRFPEVQMSRQNGMRDEDLAQEQYLIMAPRGHRLLVEA*
>CYP684D1 Mycosphaerella fijiensis
43% to CYP684A2 Aspergillus oryzae
e_gw1.8.467.1
MALTLLITIIVAFVS (0)
WKTYTALTNPLRHLPGPWISKWTNLRFQWAVMTGERASYEHALHQRYGPVVRIGLGEVSLASISAAKIVYQIGSPYHKPTWYG
TATGFGDMALFTIRDPKAHGVRRRLLAHNYSENWIKQMEPYISEKTRVAAKKMVADLDARGYTDVKKWFTFMATDIVSEA
AFGESFDTLQSGEKTQYIIDLENDGLRGFIRAELPLLNKLVAYLMFGSANEVSAGLERMKNYAEDRISRYFEAYRADPDH
VKPTLMSKAFSAVEDGTLPKVAITSDAMTNIVAGTDTSAITATYAAWYLSQDPDLENALTEEVAMLPQHFTEENLIKLPL
LNGVITETLRIRPPVGQGLPRIVPDGGADFEGHFVPGGTTVAIPAYAMHHLPQIWRDADKFDPSRWNDATKDMQSAFLPF
GGGSRVCIGQHFAMLEMRHALASFYRTFSQGMRPAWVDGFTADDMKPVSFFVTAPKGQRCLLAKRQRC*
>CYP685A1 Aspergillus nidulans AN8408.1 28%
to 613A1 613 clan
aspyridone biosynthesis
Nature Chemical
Biology 3, 213-217 (2007)
doi:10.1038/nchembio869
Genomics-driven
discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans. Sebastian
Bergmann1, Julia SchŸmann1, Kirstin Scherlach1, Corinna Lange1, Axel A
Brakhage1,2 and Christian Hertweck1,2
MGFVNTLTQASDQENQRLRASPQVFKLFVLILFVLLVLKIRRHRANRITN
QYGRQICELHGDARVAKFAFSKQLSDQGKALAGDEPFIIRNGRARELVVT
KPEHIYDFYKGDTK (1)
LADHPKPLYLNMGNYFSG (2)
LLGHAVGALAGERWSMIRRYFDPAFSFQSARQA
IPELSASIDRWLDDLPLQGTGTGKGFALEIKKPCRFLPLRLAAEFVYGEI
FDDKLFSALLDLNVLHEVILHDVIANKRLATRLGCWFDRAAAKRMEEFRS
RWMEFNLGIIQSARGASKACPAERIYHGVEKGDLKLEEFLHTLDEILFAN
VDVSSAVLGTLFEHLAVNTAFQQKLRAEIETHIQTRTHTPDTDSDIDINT
ETGKYLSKQDTLMNFAVMEAMRLSPAF (1)
AFSLPECTAVPKEIGGYR
VPARCPVVIDAKRLNADRATWGKDGDTYRPERFRDIPPSKSRYGFMRFGV
GAASGRCLGKHLADTLFKLTLIAVIERYSLHSVHDGPEVELREVVVRV*
>CYP685A2 Neosartorya fischeri
85% to CYP685A1 Aspergillus nidulans
NFIA_001570
By comparison to 685A1 with no intron at PSSK/LRYG
a gc boundary is predicted
Note: this seq does not have an ortholog in A.
fumigatus
MGFVDTLTQASDLDKQRLRTSPQVLKLFALILFAVLVLKIRARHRADRITNQHGRKICELPGDARVSKFAFSQQLSDQGK
ALAGGKPFIIRNGRARELVVTKPEHIYDFYKGDTK (1)
RPADHPKPPYLNMGKYFSG (2)
ILGHAVGAIAGERWSMIRRYFDPEFSFQS
ARQAIPQLTASINRWLDDLPLQGAGTEKEFALEIKKPCRFSPLRLAAEFVYGEVFDDERFSALLELNVLHEVILHDVIAN
KRLATRLGCWLDHKAAKRMEEFRAKWREFNLRIIQSAREASQVCPAERIYRGVEEGDLKLEEFLHTLDEILFANVDVSSA
VLNTLFEHLAANAAFQQKLRGEVEAHIQSRTHTPDTDTETDTNTHTGKYLSKQDTLLNYAVMEAMRLSPAF
(1)
AFSLPECTAVPKEIGGYRVPARCPVVIDAKRLNADPATWGKDGDTYRPERFRDIPSSK
(1)
LRYGFMRFGVGAASGRCLGKHLADTVFKLTLMAVLERYSLHSGQDGPEIELRYMNQKE*
>CYP686A1P Aspergillus nidulans
GenEMBL AACD01000154 AN8510.2
Revised sequence, now a pseudogene
pseudogene two stops and two frameshifts
33% to
613A1 613 clan? Similar to CYP5082 family
MAAVQFPIEADPQWPSNGTSPVQSLPGPFNTRF*ELFHHDQPQPPRI
PILALTARYRAVDRKRSLTGPDYVWPFGNFRHMFAESRALSHKW
RKEYGDIYRIWTGFYSEV (2)
VISTPADIATFYSDSASHKKTLALRSN*VVNKLLGACVGFTNGX
RWKRNRKAFDPLLANNVAVKHNSRSHQEAAEFVSSIATTRVDG
GSNEETMIIKAAGSFLPFTLNETTSIFFGPLTDEEKIELWDVCL
AFMGIVDTALLKG
PFRWGLGYWMLSREKYQSAKAYLARWEAFLMRTSQARKDQTDLPITR
LWRDVEVGNLSKDE (0)
LLQTLTESTVFNLEPTSHALIMTIFLISDNQAFQDNLVAELDANRSAITRYLGRKDTLL
HYALLEAVRLQPVL (1)
PFTLPEAASVDKGLGGYLIPKG (0)
TSVIADSYGINVRNPFWGPDATSYRPSRFTTLTPAEIHRNLSMFWFGARKCLGQFFA
KQVRAVVFNLFDRYKVTCSDYSGIAPGINVDKTEYVDRFGLEFLL*
>CYP687A1 Aspergillus nidulans AN9335.1
revised 7/18/07
MEGVVTMTEARTQSNVSVSDFSLVTDN
NPEKIYAQFAELRSRCPVARTADNGGFYLLTRYEDIKNAASNTEIFISSV
KAVIPSDPRGIRRPPLNTDPPAHTPYRTALDRTLRPKRLRRLEPVLREHA
EREFAKLVAKGGGDICGDFAAIFAAWVETTWLNLEDGTAPMLANTAAAWV
NAWRRQDAKETSEQSEKLYLIARELFADRRVSPRDPEQDPASSLLQERDT
NGQPLKDELLIGALRQSLVVGMVAPPLLFGNICNHLSRDKELQNRLRSNP
SLIPAAIEEFVRLYVPYRGFCRTPSRDVELCGRTIPAKSPITMTYAAANR
DPSIFSQPDEFILHRPNITSHLGFGRGRHRCAGMPLARMALQIGLVVILQ
QSSDFEVNGPLQYAGMPEMGISSCPLRITPRDSVEPLRQT*
>CYP687A2 Chaetomium globosum
XM_001226406.1 NZ_AAFU01001127.1
60% to 687A1
MAAAKTITCPFMATKLLSQERIDTSPAVISDNVDEILKEYDILR
EACPVAYTNQYGGYWLMTRYDDIKAAALDSDTFISSVRAVIPSDPRGLRRPPLNFDAP
NHTPYRTALDRTLKPARIKRLAEPLERHAEELLLPLLKKGEGDICTEFAAQFAAWVET
EWLNLARDTAPRLASTASAWVNAWRQRDGEKTTHFSTQLYDIARAVLADRRENPRDPE
EDPASSLLLERDSRGEPLEEIHLVGCIRQSLVVGMVAPPLMLGGICNHLSKNQELQQR
LRDDPTLIPAAIEEFVRLFSPYRGFARTVSKETVIHGQTIKPGIPITLTYSAANRDPA
VFDSPHEFILNRPNIAMHMGFGRGRHRCVGQPLAKL
(2)
9538
ALQTALKTLLSKTTKFEVNGEMQFSRMPEMGIISCPLTFKIE* 9666
>CYP687A3P Aspergillus
flavus
AFL2G_07246
Note first part is CYP687A like (65%),
Second part is CYP645A like (39%)
The CYP645A sequence has a C-term extension as
in CYP645A1
this second part which occurs after the heme
signature in CYP645A1 resmbles a
phthalate 4,5-dioxygenase reductase subunit
This gene seems to be part CYP687 (first 137
aa) and part
phthalate 4,5-dioxygenase reductase. The P450 would not be functional.
This may the created by deletion of part of
CYP687A and CYP645A genes
that were adjacent in the genome.
The second part is 46% to Saccharopolyspora
erythraea AM420293.1.
This is a 7% better match than to CYP645A1
MFFTTTPSADEDFALIEDNNPDKIYEQFGQLRRKCPVAHTSQTGGFWR
LTRHDDVERAASDPDTFVSSVKAVIPSDPRGIRRPPLSTDPAAHSPYR
TALDRTLKPARLKRLAPILERHAQRELDALLKTNTVDHQDA
(deletion)
KIHYEKVRPARGVAGVVVAWDPPLAPSLRTLPHGSSTEMASSTTQNMSAKVLSLKSMT
SEVLGVTICSNTPDELPQWTPGYHVDILSQYGYRQYSLYSYPAETSFWKLAILKEENGC
GGSKWLHENLREGMDVTVRRPKNHFRLRKRPRYILLAGGIDITPLTPMLSELK
CNGADYHLIYLGRPRGTMAYVEELCRGHPTEVWTSQDGKGFDLESFVKAQEKNVQ
IYCCGPDRLINALEDACRENVVVELRVERF
NKSFHVTLGRSGRRLTVPPEKTLLEVLNQNGCGIMSTCSK
GTWGTGEISVLEGRPEHRDTVLSPEEKGKNKVMMPCVSRYLEEELVLDLW*
>CYP687A3P Aspergillus
oryzae
Supercontig 25: 1280400-1280807 (-) strand
51% to CYP687A3P Aspergillus flavus (best match
in A. oryzae)
possible ortholog, the reductase part is not found in A.
oryzae
This gene seems to be undergoing some kind of active
decay.
Other P450 pseudgenes are still 98-100% conserved.
Adjacent to VIII left telomeric region
MFFTTTSSADNNFALIKDNNLDKIYKQFD*LQRKYLVVYIF*TGDF*LLIYYNNIK*TIS
TTNIFILSIKVIILSNL*SIYRPLLNIDLLVYIFYYTALNRTLKSARLKRFGLILKRHTQ
RELDVLLKTNNIDNLD
>CYP697A1 Heterobasidion annosum
AY827553
MAYTPGVIDALLAVVAVLVIKTIAQKRSSSPLPRGPRGWPIIGN
VLDMPKRSAWEVFSNWGDKYGNLVYVSVLGQPVIIINSVKAAVDLLEKKSSKLLGPPA
VPNGPSHRLGRGPHLHGVRQHLSPSAQASPPRHWLARAHAELPRSHRERVHAFTQRLM
KNPEDKTELIKRSTTAISMLMAYGYEIKEENDPVVKLAEQSVEDLGHLLESGNFLVEI
FPWLKYVPEWFPGAGFQKTVEEWKTTLDTIQRTPFEFTKAQVAAGTAIPSVVSEYLDK
DGGSSEDEVAVMRTAANIYGAGSDTTTSAISTFFLAMTLFPDIQKRAQAEVDSVLGTG
RLPTLRDRDNLPYIDAVVKELLRWRPIFPLAVAHRLSGPSDDVYDGLLIPKGAVIIPN
TWRFMRDPEVYKNPLEFNPLRFLPEDGSEPELSPYGFVFGYGRRICPGVHMADAVLFN
MCSMVLSLFNISKAVDSNGVPIEPSTDYEGEATRRPMEFPCIIKARSKTAEQLILGS
>CYP698A1 Penicillium paxilli
GenEMBL
AF279808
Young,C.,
McMillan,L., Telfer,E. and Scott,B.
Molecular
cloning and genetic analysis of an indole-diterpene gene
cluster from
Penicillium paxilli
Mol.
Microbiol. 39 (3), 754-764 (2001)
Gene name
PaxQ
note TG
boundary at intron 1 not AG
MDFVLSALQRDSWGIAAIILVSIWALHSFHRSRKLQ (0)
IPVPYVGKCGILGPWISALQWESKARELVQEGYEK ()
HGNFAFKVALLNRWEVCICNEDMIREYKNLMDNQFSAIAVTSE ()
LFQIKWTAPGTEEGAHKISIPLLGKALTWQRNRSAAQNDPYFSEFV
EEFLYAWKEEVPVPENGDYELPCFETGARVVAHLTARSLVGYPLCRNPEIVNLFTDYG
SAVPTSGFFIAMFPEIMKP
FVANFCSAPRISKRLQAILLEEFAKR
REEGGIEST ()
DIMGWLRNWTDQNEPGVYGDLEITSSIIATIFGAIHTTTQ ()
VLVHCLFELATRPEYVEPLRVEIQSA
LEEHGGWVKEGIEGMVKLDSFIKECQRFNPLDAG
SLARRATKDFTFKNGLTIPE ()
GTFVFAPNGPILFDDTLYPEARQFDGYRFYNLGQKTGKPQDFRFAATNQKYLQFGDGRH
()
TCPGRWMASDEIRLMLAHILMNYDIATKDNKGRPENWIFKKILFPDMKAVVILKARK
SVSA
>CYP698A2 Aspergillus oryzae
GenEMBL
BAE65190.1 AP007171.1
61% to
CYP698A1 with some assembly errors
698A1 is
from an indole-diterpene gene cluster
note the
other P450 in this cluster is CYP653C2
The ortholog
of 653C2/paxP (653C1) is 4 genes downstream of this gene
14 P450
genes and 2 pseudogenes on this contig
probable GC
boundary after VTAE
frameshift
after VETIL
1893711
MSRLLERTLDRFTGLLEYQPTYPFAAPTWVYLVGAILIQQLATRWYRYYKSW (0)
VNVPVVGGHGIIGSWIAAFWWTARARSLVNEGYQK (0)
HGDFAFQVSTPTRWEVFICNDEMVREYRNFTDERFSANAVTAE ()
LFEAKYTVPGAAEGVHKVPVPIVAKALTWQRTRAATKTDPYFEEFVKELQHAFDAETKFENED
WNDLCCFATGTRIVAHLTAKSLVGYPLSRDTELINLFAEYGNAVPTSGFFIAMFPQILKP
(2)
FAAKFCSAPKISARLDRIVMDELRKREANPRSEPQ (0)
DITDWIMFWSRTYPGTYTDQDIARSVVSAVFGAIHTTTQ (0)
VLVHCLMDLAIRPEYIHPLREEVETIL
IGDNQQWTKEGLESMEKLDSFVKECQRFNPLDA (1)
GSLARRATKDFTFSKGLHIPE
GTFVFTPNSPVLFDEKHYPDAQQFDGYRFYRLGRVTGRPLEYKFIAANLKYLQFGDGRHIC
(2)
PGRFMAADEIRLLLAHILVNYDIRPKDDGERPPNWTF
KKILFPDMKGMVQLKRRSINISQPN* 1891669
>CYP698A2 Aspergillus flavus
AM921700
97% to CYP698A2 Aspergillus oryzae = ortholog
complement(join(11445..11634,11697..11940,11996..12176,
12236..12352,12397..12508,12562..12929,13003..13119,
13172..13276,13329..13484))
/gene="atmQ"
/function="aflatrem biosynthesis"
MYRLLERTLDRFTGLVEYQPTYPFAAPTWVYLVGAILIQQLATRWYRYYKSWV
NVPVVGGHGIIGSWIAAFRWTARARSLVNEGYQKYGDFAFQVSTPTRWEVFICNDEM
VREYRNFTDERFSANAVTAE (0)
LFEAKYTVPGAAEGVHKVPVPIVAKALTWQRTRA
ATKTDPYFEEFVKELQHAFDAETKFENEDWNDLCCFATGTRIVAHLTAKSLVGYPLSR
DTELIDLFAEYGNAVPTSGFFIAMFPQILKP ()
FAAKFCSAPKISARLDRIVMDELRKREANPRSEPQ (0)
DITDWITFWSRTYPGTYTDQDIARSVVSAVFGAIHTTTQ
VLVHCLTDLAIRPEYIHPLREEVETILNRDDQQWTKEGLESMEKLDSFVKECQRFNPLDA
GSLARRATKDFTFSKGLHIPEGTFVFTPNSPVLFDEKHYPDAQQFDGYRFYRLGRVTGRPLEYKF
IAANLKYLQFGDGRHICPGRFMAADEIRLLLAHILVNYDIRPKDDGERPPNWTFKKIL
FPDMKGMVQLKRRSINISQPN
>CYP698A2 Aspergillus flavus
98% to CYP698A2 Aspergillus oryzae
59% to CYP698A1
AFL2G_05467 revised
MYRLLERTLDRFTGLVEYQPTYLFAAPTWVYLVGAILIQQLATRWYRYYKSWV
NVPVVGGHGIIGSWIAAFRWTARARSLVNEGYQKYGDFAFQVSTPTRWEVFICNDEM
VREYRNFTDERFSANA (0)
LFEAKYTVPGVAEGVHKVPVPIVAKA
LTWQRTRAATKTDPYFEEFVKELQHAFDAETKFENEDWNDLCCFATGTRIVAHLTAKSLVGYPLSRDTELIDLFAEYGNA
VPTSGFFIAMFPQILKP ()
FAAKFCSAPKISARLDRIVMDELRKREANPRSEPQVQ
DITDWITFWSRTYPGTYTDQDIARSVVSAVFGAIHTTTQ
VLVHCLMDLAIRPEYIHPLREEVETILNRDDQQWTKEGLESMEKLDSFVKECQRFNPLDA
GSLARRATKDFTFSNGLHITEGTFVFTPNSPVLFD
EKHYPDAQQFDGYRFYRLGRVTGRPLEYKFIAANPKYLQFGDGRHI
CPGRFMAADEIRLLLAHILVNYDIRPKDDGERPP
NWTFKKILFPDMKGMVQLKRRSINTSQPN
>CYP699A1 Agaricus bisporus (mushroom)
GenEMBL AJ312129
Eastwood,D.C., Kingsnorth,C.S., Jones,H.E. and Burton,K.S.
33% to CYP502A1, 34% to 620E1
MPILSLARDILFISLCGLIYRIFRNRRNRLLPLPPGLLRWPILG
NALSMPLTYAHIYYKHLGNKLGSKFIYLEAVGQPFLIINDYRVAKDLLEERSAIYSRP
QFPMSTEVIGLKRFFLLMPYGDIWRNHRRVFRQYFDPKYLPRDQEKQLNFIRKSLLPN
LFIAPEEAHEHVANCIGGFILSIVYGLPVKTRHDRLVRFAEKTFNDLAASTAPGKYLV
NIIPQLQYLPDWFPGTEFKRVALKTAEELDKLREEPYQAVLIAMVGHVVQNCLVSDNV
EKLRNAPDFEDRIVDVKEVARTIFGAGFETTTGVIMTFVLAMLLNNDVQLQAQSEIDA
VLGPERLPTFSDLSDLPYFSAVIKEVLRWNPIGPIGIPHATTNEDEYDGYYIPKDCIV
VSNIYAMLHDENIFPDPEKFDPGRFMKNGTTINDDLLNPIDVVFGFGRRVCPGSHLAM
SMLEITAASILCLFDILPALDAQGKPIDVVPEFTPASITSHPLPFKFNVSPRKGKDVE
GLLSEYMNVEYA
>CYP699A2 Agaricus bisporus
partial mRNA for cytochrome P450 (cyp gene).
AJ271708
84% to 699A1, 42% to CYP502 Coprinus cinereus
AB013443
ENVEKLCNAPDFDDRIAEVKEVARAVFAAGFESTTGNIMTFILA
MLKNHDVQRQAQSEIDSVLGIERLPTFSDLSDLPYFSAVIKEVLRWNPPVPIGVPHLT
TDEDVYDGYYIPKSCIVMSNIYAMLQDETVFPDPEKFDPGRFIKNGDMVNDELLNPKD
VIFGFGRRVCPGSHLAISMLEITAASILCLFDILPALDTQGKPIDVVPEFTPASITSH
PLPFKFTFSPRKGKDVEGLLSEFMNVEYA
>CYP5025A1 Ustilago maydis
GenEMBL XM_404078.1 in the CYP52 clan 39% to
557A1
MSLKVQLPHSSLCRIGQRTTGAQGGLSSDKAAQKEKVGPLKSGLLFSYMQNFCALQTRLRRPSRTTE
LDTMDFKPFLTLQHFRPQGFAGDVLAPGASYNQTWNTMASKFNGRGGNRVETGKVLEAASESLKETV
PLLQLVVRARHHPLLVFLVGLFLGTIYLLYRYWDCAVGCERRPDLKGPKGLPLIGNLMWALKNRDPL
SYQVYAQQKYGYGNTHTLPGLGRLIDISRPDWIEHVQKIKFSNYVKGEQFHDQMRDVLGDGIFTSDG
ERWKMQRKVASRIFTVSSFKAIITQTIREDCALVEQLIETYARQGTVFNLQELYFKFTLSSFVKIAF
SQDIKSLSEPDRPDTFGDAFNYAQKVLDMRFVQPWWKIAERFNETGRKMRAARKIVEEFTTNIVEAR
RKESEAMGEKSKPESSRKDLLDLFMAYRSSDGQRLSNQQLKDTILNLMIAGRDTTAEALSWMSWHML
TKPDVYDRIRHEIDATLEEEGEQAGLEIDYDVFEQHTAKLTTFQETLRLHPSIPKNIRRALQDDVLP
NGGPRVRKGDLMLYSDWAMGRNPDIWGPDACEFKPSRWTDQETGSSIKYSQFQAHFFNGGPRLCLGQ
KLASYEVVQLIHHIFAKFDLELIDLGPGRSAGFGKVPDYLNSLTHPMKRPLMVKATLRCCKEGTR
>CYP5025A2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
59% to CYP5025A1 Ustilago maydis
e_gw1.3.736.1
MSPKEEILLLDDSENILNSRASIQNQQLVYVDLKDHIKHTIPGPLNIPFVGSLYEMLPNITESWVRQFEK
YGPLVSVSILGTEMINTNNVDIAEIFSKESEYFTKRIKGSVLSEAKRVGLQGLFTTDTDETDWRLAHQLL
MPAFSSRAIKAYQIEMGRLVQQTIRIIEQIPQDGPVDIIDLSTKLTFETIGRIGFGYKFGLIDSLNSPSH
PFIGAMSYCLQQAVVRTQQARFVRSLPTEANRTFDRSLKLMHDIVDKVIQDRKRVPKSDTDNSESDSDSD
SNNNKDLLDFMLYARDENNLGLSDENMRDQVVTFLIAGHDTTANTVAWALYEISRSPEVEAKIVQEIVNA
GITAEELPTSEQISDLKYITQVIKETLRRYPPIRIISRICKKNCVIPGGYLIKKGSSVGVHLYSLHHNPE
IYPNPYRWNPDRWTPEEEQKRSRYSWMPFSTGPRACIGMAFSLQEMKTSLAMLLQKYRFIYDGPPIQFDP
KMATTKPYSFMMTVKPRTSFPQSNVSLK
>CYP5025B1 Ustilago maydis
GenEMBL XM_404088.1, EAK87284.1 in the CYP52
clan 38% to 557A1 if inserts removed, 42% to 557B1
MISLVQHSFDFFETRLGLAVGFIITLALVYRDRAVFVAKCDHIKGPPGLPLLGNTLQVFKEAADPLQ
AMLSRSAVYGLPNTMTVLGMGRAINITRPDWIQHVQKTNFSNYVKGPKLHTCLKDLLGDGIFNADGH
SWKAQRKVGSNIMTMSNLKNLVAGVLDAQSQRFSDLLQQAAKQGTPIDLQKAYFDFTIQTFLRIAFS
TDLETVQSTRIATRSEQQKAAQHLSFADAFDLAQRLTVRRINRPWWKLTRRWEPSEKKLEHAIRTID
RYLYPLIERRSQNKSKADKRHADLLDLFLSYRDDQDQPLTPKQLRDALLNYLLAGRDTTAESLSWAS
FELLRHPEVVHDLRQELMSHSIWFDPHQKIDDDDAEQRSSSFELSHTKQLHHVRSIYHESLRLHPSV
PRSSKIALQDDVLPGGVVVPKDTTVIWSDWLLARNKSVWGDDADEWKPRRWLNAEGEFINESPWKFH
AFNGGPRTCLGIQLAQFQGMYMLSRIFSDFDLELESDRGLHFEPEVENTLTLPMKHPLMVRVYTRAK
TSRAP
>CYP5026A1 Ustilago maydis
GenEMBL XM_399338.1 in the CYP52 clan 45% to
EAK82744.1 36% to 557A1
MPAFPSSSAANSAGRHIELRSDNAYVQHLVHVINTVLERTGLALPVLVLTLLFLTIKYHNRTIFAKP
PRKELYSPPAWPLIGHTLQAMKYTDNILDWFLEQSRKHPVGFSASIAGTGSGQMNFIYRPEYIEYVQ
KTNFENFEKGQAVKTRFSDLLGQNGIFNSDGHVWKTQRKMASHIFSVYQFRTWVQTVVQREMDSVVG
ILDALTEGKSSSDPATLLLPDLFFRYTLSSFGKMAFGSDIDCLSADPSCLEREVEFSNAFDFVQMVI
DKRFRKPMWQLIERFSSEGRKNARMVKKINSFSGQIIEQRLREREAGIQKEKMTSDGKEGKDLLDLF
MDITTDRDDLISVVLNFIIAGRDTTAQGLSWLFYELMKNPQYVEEIRSEIRNVLGNTDGSIRKLDYD
TTKDLVFTQACFNEAIRLHPPVPKNGKRAIKDDVVVPQGPTAAGLPPIKIYAGELLSWSDWVIARNP
EVWGPDCCEFKPMRFIETVTNEDGTKTRSLKNFGQWKFHVFNGGPRLCLGMTLANYEALSIIAAVMN
RYDFGWGTKAQGQTADWPLKYLPSVTHPSQMYTATVVRRDELM
>CYP5026B1 Ustilago maydis
45% to CYP50026A1 GenEMBL XM_399478.1 in the
CYP52 clan
MSILLPTVHSSFEHLTPTHVAIASVLILGLLCLIAPDRYIFVSHRKGIKEVPGALPLIGNLLFLLDI
AAKRRRFLDEFLRMQKSIGAGGMPWAATFPYLGGRVTSINRPEYIRWVQKTNFENYIKGSFFQKSMG
DVMSLHGIFVADGEIWRKQRKMASHIFSVGNFRTHVQNTIHRDLAILNKLFRDASSKNTELNLPDLF
FRFTLSSFSLMAFSADIKCLPSNVGDLSKVVEFAANFDYAQRVMDERFVDPLARFTELFSPQGRKMR
RTIKELHSFCYEIIDLRLAARARGEAQAASGKGDKDLLALFMEQNLTRDELLPVVLNFLIAGRDTTA
QALGWLFYELSKHPECIEKARQEIHEKLGSGSSFQSMAYDDLSSLVYVQACFLEALRLHPSVPKNIK
LAVKDDVIRPYAQPCSDADVAPNAVPTTQKLPDLVIKKGETVTWQDHTMARMPELWGEDCEQFKPER
FIEERKDGSIGIKTYSQYLFHAFNAGPRLCLGQTLATYEGCAVVAEILGNFDVVYDHKALKEDEPTY
DDSLTLPIKNPYTIHVRARDD
>CYP5027A1 Ustilago maydis
37% to 530A1 with some insertions deleted
GenEMBL XM_401724.1 in the CYP64 clan
clusters with CYP664, CYP665, CYP530 and
CYP619
MFALEVDERSKLGSLLLGSRFKLADSVLARGEWIFAATAAAAVLVLLTLRFQAGQNCQGRFKRIPGP
RQLPIIGNIGQVDAARQHPKFLEWARRYGEIYQVRFGSNRIVVLNSAKASIELLDRRSSIYSCRQGP
HFAHDLMSAGQRQVFLPYSKEWKAARASVHPFLMGTKSQGYKTIQEHESAVLIHDLLRHTQHCLSHR
RDQDLPLTHETGWEAHVRRYTTSVVMNITYGRRVTSTYRNPELHKIYDVLGNLAVVGQPGRNACDAF
AFVRKLPDWLAPWRVQAKAMHKWEMELWGGLLERTKRDRQHGRPCQGYVASVLDRRQHAPSSASFDG
SGLTAEGEMTDLLLAYTAATVLEAGSDTTASSISFFILACLNNPRIWDKLFKELISACGDALPTFDK
IQDIRYLRACIKETLRRRPPTIMGIPHRVIRDDVYDGYLIRAGTVVMGNVWAIHNDPQRYPNPEKFE
PERFLGDDLSAAQSAATMDAERRDHYTFGWGRRVCQGMHIAENSLMIVLARLVWCFELSTPVSSDGT
TPIAVPSIDQEANFLPGFVSQPKAFACHFVPRSDHVVQTLENAAAEAQEYWSANDLEPDQRDHYYKD
>CYP5028A1 Ustilago maydis
also named CYP5079A1 by accident
37% to 532D1 GenEMBL XM_399810.1 in the CYP53
clan part B
MTTAPHTGIVESSVVATLAKILLTPLSGWPSMLQLLTGSFVLLFGWIVYNLAISPLSRYPGPLSARLGIPFWRFWHSLQGDYAPALYSLHRKHGDVVRIGPTHLSFADPTAMNSIYSLSDGVSSKFRKSNFYRSFQVFKAHPSIFSERDPHQHSKRRRAVASAYSMNSLVKLEEYVEDVTELLLKRLDELVETNSVVEGGGTSEKTKTKAVRLDPWFHYFAMDVVGELAFGQSFNLLHRGKDDERFLTGVLNLSQWGAVAGCMPLLSSLILWLFPRITGQPGGSVIGDKTTSRIQTRYAEVQDNGGVASRPDMLTKFMEARDPDTKEKYSMKQVLFSASSVMSAGSDTTATSLTIFFGYLLEHPACYAKLRQEINEAIQAGHLISPVKYAKGAQLEYLQACIKEALRLSPPISMDLPRYVPAGGALIGKNPHVIPAGTTVGISPYVLHRQPEAFGADAEMFRPERWLEGGEEGRKAMERFNMTFGGGSRACIGKNISLMELSKTIPEILLRYDIKKPAVSTHLHTTPSNAKQPFFQGKSAWFLEAHVSHHRFHNFE
>CYP5029A1 Ustilago maydis
GenEMBL XM_403406.1 38% to 65M1 C-term in the
53 clan part A
clusters with CYP671, CYP628, CYP670 on trees
MAQTAMQSFEQHRFLCIAVLSVASHHLIFRHVELWPMQLLALTTALFSIDVSLRHSVNKTTLFPDAA
KLAYVDLAVWTLGVLISIGVYRLFFHRLRHFPGPKAWAVSKFALMTTDAKGLRPRALEEAHKKYGDV
VRTGPREISINAPTAIAPIMGAKSSFWRGPWYEATAGARGAHVPRNLHSVLIESDHSARRKIWDAAF
SAKALKGYETILVDNIDNMVNQLEKRSQRKETVNIDDYCSFYSFDVMSQAGFAGDFGLLNHGQLTPM
IQALEDFMSFVQLVGNLPYLVEVFGLLPNPIAEFDKYMTRIVMERKARKEAVPDIMGHLLHEVETEK
GKSSKRQDAEATTDARLIIVAGSDTSSTTMGIAMFFLMEHPKILADLRQELLDVFGDDASLLTDFAR
MDDKTCPLLNAVINESLRIFPPVPTGLQRESTSPAVVDVNGQKVVIPANTIVTLPIWSLQRDARNFS
PEPLRFRPERWLHPENEEHFNKTAFTPFSFGKTSCVGKVLAYMEIRLVISNLVRRFDFVPTGNYDAQ
KFQDSLVDAFVTKRNHKLPVHVKVRNHVGP
>CYP5030A1 Ustilago maydis
also named CYP5072A1 by accident
GenEMBL UM06459, XM_404074.1 43% to 576A1 C-term in the CYP53 clan
clusters with 576A1 on trees
MAKLSRLDPCSRIAVYVERTHGLLLEVQQPSNTKRLDLLASLNPHLNAPPSAAKMLNETIFGRQVADVREHGLFGRPFWLNALYAFLLYSAFLGYKSYFLHKTSRIPGPWHLHWTMLPALFYYVRGTQWRYVDKLHEKYGPLFRLGSRQIYVSDKDAIRQLLAKENLPKVNWYASLSRDPKTAGMFTTVNKEYHRSRRRLMSPAFAVEFTRQLEPFLVDATTKLFEGYHQRVQKASDPFKPLLFNVYEDLACLAMDILGETAFGVSFNLVACRDDPGADRKFADINKLLAKYLHDGGIRFFCRPFDKYMKRDLNVYKLTNPLVDARFAETEARRAAAGDAAEQVETREDILQYLVDASLEMQKGQKEKLTRTHVRDQCVELLIAGGETTSNTITYILKALLENPAKLAKLYETIEPEPLDDAVPGFTQLPETPYLDACIQEGMRMYPVTSELGRRTGKEPTVVLGHVIPPRTAISASLRALHYSPKYWASPNRYWPERFLPADSIHSASDPAPAADMEAFMPFGCGPRNCIGSKFAWHEMRMVLHTLLARYTISAVEATDKVDFRQFVTFQLAKPEYRIAVTPRMALKA
>CYP5031A1 Ustilago maydis
GenEMBL XM_401804.1
clusters in the 56/547 clan with CYP616,
CYP617, CYP618, CYP582, CYP547
MSFEVTLSSAAEQIFALLLKPISLIRAYPITSFLASLVLVPLFLVLSAALFFFGIATWRYISLHIL
GTDMYSHIPRPARTDRYPLLTGHLGYIRKSPPVEGHLTFHRELNTKVYVYRGLFYSPRLMISDAKA
MLHMLSAANSYNYEKPASTRLVLKNFLGEGVLVAEGDVHKRQRKILQPAFSVGAIRELNPIFMRYS
RDLVEKIGQMVDRSNSNAKEGGVDGVTRPFVAQSSYAMKASKPGEPVIDIGWWCIRAALDIIGDAG
FGYHFEALKVDVDPSIVVRRAGDELGDAFNTLFKLSLKIDIVRFLQLYLSNFKWLKWVNSIPNKRK
WATDSAYGELEKVSMQIVDRKKAEIRGEMQDEIEARGKTTSSDAFTKADFDEKDSVSTNGSAPGKD
LLHLMMRANMAADVSPKEKLDDAELIGQITTLLIAGHETTSNQTAWTLWLLAQQSSVQQKLRDEIH
DHFGRGMERDPGYDELMSMPYLDAVCKESLRVNSAVPSTIRVAKTSADVPLSKPYPTRDGRGTFNS
IHIPAGREVIIPITLINIDDEIWGPDAAEFVPERWLDLPPAPRQNGLPMHLMSFISGPRGCIGNRF
ALAEFKAMLCHLVGSFHFETVQDWKVEAKQTAVIRSRVVGQEDVGPQMPLRISRIPTV
>CYP5032A1 Ustilago maydis
GenEMBL XM_403279.1
clusters in the 56/547 clan with CYP616,
CYP617, CYP618, CYP582, CYP547
MQVKLSSSSLVSESVLGKLAATAHSHRPTTFIGYVALAIGTVVLLLGLLITYSLAKMLYRTTIYHYY
ISPLRHLPGPDPKPFLGNVEEFAKKPGAGAELDWSRKYNKDGVYRSTFLFGREAIHFHRPKALRQIL
VEDPYTYPKPALAWKLLGLIAGYGLLTVEGDTHRKMRKTMNPAFSLTNLIEQFPVYYAKIYPLVDVL
NQKVEESPEESAVIDCDAWVNKALLDIICLTAFGYDADSVNNPSNELASAYHAVTSMQNGRNQARLN
LLLNLPFGDTVLDWASDTSGWDWFLKRCKPGTAWQTFFQLLNGMHRIKNVSKEILYKQLNSGERAAQ
GGQFKAIIDIIEESYLTENDGKPKSLKQAERDMITQVLTFLGAGHETTASGVSWTLWNLATHQDIQD
KLRKECKGLMDQDDRPPYSAIKGLAYLDAVINESMRITPPVPRTIRMASKASYIDGIYIPKNTLLPI
SNRAINMDPTVWGEDADEFKPERWFNLPDKYDRTFSMITFIAGAHACIGRTMSYLEMKAVICILVSN
FKFEPVSKDQSPIMDTLITMKPQGGLELRVSKV
>CYP5033A1 Ustilago maydis
36% to CYP5034A1 GenEMBL XM_399595.1 37% to
white rot Scaffold_7 C-term
MAISTSSRLVIHQDVLSWLQHRPFASAFTLLVVYITYKLAIKPILFPSPYRHLPRPERASYILGQRI
VEANGLTYIDASTNQRVKVSGPGEVCKHYARTLDTSVFVFPEPFGGETLFISDPFALNAILADVDKF
QSDLLRTTIIEFIVGKGIVARFGDAHRKQRKLMAPAFTPAHIKGLTPIFAKYAQLMCHKIALADDES
VDFAEYLDCTMLDIIGEAGFGYRCSALERGRGGSELSSAFNSVNQAAIDFGPARAIHLGLSAMLYPR
ASIWPLSEANRRIAKVNRVMDRITMQIVREAKSRVEKEGEDLGDKKDLLSLLIKSNLDARIGERMTD
KEISGQIQTFMFAGYETSSVTTSWTLYFLARHPEVQNKLRNILTATLSERKGIPLEELDVSTLEYDD
VWCQDLEYFDWILAETLRLCPPLSGNDRQAMQDSVLPLMTPVKMTNGENVSQLMVKKGSRLTIGIKT
VNCDRKLFGDDADEFRPERFAELPQRHAEAKLPPYATYSFFGGPKSCIGSKFALTEMKVIIIAVLSR
FQLSPEPGVTIKQHQALIVRPRVETSTGGPAAGMPLRIKRLPHQVSV
>CYP5034A1 Ustilago maydis
36% to CYP5033A1 GenEMBL XM_397817.1
MSTTLSNKLVRWASSHPFVAAFLALVLVSTLYLAWKRASAKPSVWLNLPGPERTSFLTGYSRDPKKK
LGVKNPTAPDREPIIGDDGVDITETPGVAIARLYDEYQCDHLVFPRPIGGELLITRDAATMNHILND
SYNYTRSTAGTKATKIIIGNGVVAVFGDEHKKQRKMLAPAFSVDSLRGLMPIFTQATAQMMDRFGKD
TSLEKRWGRDVKDSVKWFGRVTLDIIGRAGFDYDFGAVEQGPNGLAVRSTFHDAMTSTMNVSPIDAV
VGAFMFFVVPSLLYILPLTENVRKLREMRSELIKCSHKIVAAKAKQIRKELEAGVDAKETFAGKKDI
LHLLMRANMSPEIRPQDRLTDETLAGQIVTFIFAGHETSGNTMSWCTFFLALDVEYQQKLRQHIQKA
LKEMGKDGDAITELTWADVNSEEMRPLDLCIQETLRLRPPITTTFRYSTKDDQLPVTTPFKTKDGRT
LSTIPITAGQEIAISVTGNNMDPKYFGADPHRFRPDRWNNLPDLHAKSKLPSPYGSFVFNGGPKVCI
GSKFAMTEMKVILVNVLAKYRIEPVEGLKYKSVEAVVQRPAVIGFEKEGSQLPLRFVHDPL
>CYP5035A1 Phanerochaete chrysosporium
AY866400.1
Scaffold_9
MADTSLLSRRLKSFFDPQGSPTLLSLPDSFVVTACAAIVVHLIF
KRWEPMKLPIVAFLLFLVPACLSLLFASHLSLTKGLATAFATFYTVLVSSIVIYRISP
FHPLARYPGPLAAKITKWWHAYHVHTGKQHLYVRRLHDQYGDIVRIGPNDVSIRDASC
ISSGLGSQGLPKGPMWDGRFMYSPIPAMVGARDHAYHMQRRRPWNRAFSATALKEYEP
LIYGRVHQLVSALADRQGQVVDIAKWIGYFTYDFMGDMVYGGWTEMLRDGKDEDGLWD
VVHRGLDVSAVYGEVPWVSYYASMLPNVGKDLKRMRKMAFDRAKQRYDSGSKARDLFY
YLSNEDGAEKVTPPRPIVVSDGVLALIAGSDTTAIVTATILYSLLCNPTTYHRLQQEV
DKFYPRGEDPLNPKHYKDMHYLEATINEGLRLFPATPSGTQRAPAPGKGDRLIGKYYI
PEGTATKFHFWSIQRDPRNFSHPDTFWPERWLVAEGLEHADEPLTHNANAFVPFSFGP
YNCVGKNVAMQEMRMLLCHLMHTLDLRFPEGYVPRAFEDALEDQFGFKVGELPVIVQR
RE
>CYP5035A2 Phanerochaete chrysosporium
scaffold_69a
GAHLVFKRWEPKKLRVVTFLLFLVPACLSTLLLPHFGTALG
LTVGFLTYWTALTLSIVFYRVGPLHPLYQYPGPLPAKISKWWHVWHVQQGKQHLYLQQ
LHDKYGDIVRIGAS
GPNEVSIRDPACITPVLGAQGMPK
GRNMWPETAPLIGYRDPAEHMKRRKPWNRAFSSASVKEFEPIIQHRVHQLVEALSDRQGQVVD
LAEWISFFTY
DFMGDM
XXXXXXXVPWVSYYAKKLPWTAQDNKAMRVMAFSRTEQRYASGSASKDLFYYLV
SNEDGSEKVSPPRNIVIGDGLLALVAGSDTTATVVANTMYELLRHPAAYRRLQEEVDKFY
PRGEDSLDPKHIKDMHYLEAVM
SNEGLRMYPAVPSGSVRAPEVGKGGKIAGP
SYIPEGTQTRIHFWSVQRDARNFSFPETFWPERWLIAEGIEPAPAGEKLVHNPNAFTPFS
FGPYNCVGKNIALAEMKQLLCHLVHKLDVRFADGVDPDAFDRASEDRFIYVVGELPVVV
ERR
>CYP5035A3 Phanerochaete chrysosporium
scaffold_249a
MAGDLSTRDALGIIVVSAL
GTHAIFKRWEIKHILVVSTLLLFLPAALSTLLIPHLGSFKGIAAGFSVYFITLLSSI
TLYRISPFHPLAHYPGPLLPKISKIYHIAKVSSGKQHLYLQELHNQYGDIVRF
GPNEVSIRDASCIMPVLGAQGMPKGP
MWQGRHFWTEVHTLIG
FRDPKAHQRRRRPWNRAFNTAAMKEYTPLMQNRVRELGDALVARQGQVVDLAEWIGFFT
YGFMGDVYV
FGGWTNMVREGGDRERLWEVVKSGLK
IEFIYDNIPWLSYYTRNIPGAGNAELRAMAIGQTEKRYSRTSTSKDLFYYL
GNEDGAEKEDPPKHTVVVDGGLALVAGSDTTSSVLSSIFYCLLRHPDTYDRLQAEVDKFYP
PGEDSLDPSHLSDMNYLEA
GLRLFPAVPSGSQRAPEIGTGGKLVGP
YYIPEGTQTRIHFWSVHRDPRYFSRPEAFWPDRWLIA
EGLQAHAAGDEPFVHNPNAWTPFSFGPSNCVGKNLALQEMRMVLVHLMHRLIVRLADGWD
PAQYEREMEDRFVFSIGRLPVVVERRD*
>CYP5035A4 Phanerochaete chrysosporium
scaffold_249b
MAAREAILIIALFAVVST
ISHVIFRQWEVMHCSVVLGLLVVIPAVLSTPLVSDFGIPCGLALGFTTYFAVLLLSITL
YRISPFHPIARYPGPLLAKISKIYHVSKIWSGKQHLYLQRLHEKYGDIVRI
GPNELSIRDVSCITPALGAQGMPKGP
MFNGRHLWPETHSLIGFRDPKEHQRRRRPWNRAFNTASVKEFNPIIQARVQELGDAFAAREGQ
VVDLAEWIGFFT
YDFMGDMV
FGGWTHMVREGADHNGLWQLIKSGMK
VSFVYEHIPWLSYYVKKLPGAGSDLKMMRAMAFGQTEKRYATTTTTRDLFYYL
TNEDGSEKVDPPKAVVISDGALALIAGSDTTSTVLTSTFYCLLRNPETYKRLQEEVDMFY
PAGEGSLDPKHLPEMHYLEA
GLRLFPAVPSGTQRAPEVGKGGKAIGP
YYIPEGTQTRLHFWSIHRDPRNFSHPEMFWPDRWLIAEGLQECVGEKLVHNPNAWLPFS
FGPSNCVGKNLAMQEMRMLVCHLVQRFNFRFADGYDPAQYERDWQDRFVVMIGQLPVTIERRA*
>CYP5035A5 Phanerochaete chrysosporium
scaffold_141
MPSGILGQLQSLPAKLTAQDATL
VAHVIFKIWEPMQARIVSLLVIIAPLLLSTLFIPHYGT
VSGVFRSFAIYLTTLVSSIVVYRLSPWHPLARYPGPLLAKVTKLYHALMVSKGKQHVYIK
ALHDQYGDIVRI
GPNEVSIRDAACIQPLMGAQGLAKGP
SWSGRSMFPPISPLIGIRDPAEHARRRRPWNRAFNTNGIKEFMPTIQTRVQQLAEHLGERH
GQALDLAEWFSFFTYDFMGDMI
FGGWTEMMRDGGDLQGLWTRVKAGLQ
HAGMVPEHVPWVAYYAKKIPSVVRKVSEMRGMGISRAKMRYQQGSTSKDLFYYL
SNEDGSEKVTPPPEVVTSDGALALVAGSDTTSSVLSNLFYCLLRDPVSYKRLQEEVDKFYP
PGENSLDPRHINNMPFLEAVI
NEAMRLYPVVPSGSQRSPEIGKGGRAVGP
YYIPEGNQARVHFWSVFRDSRNFSHPETFWPDRWLIAEGLQESPEKITHNANAFVPFS
FGPANCVGKNLAIQEMRLAVTHLMHKLNFRFADGFNPDEWDSQIQDVTVMQLGKLMVVVERRD*
>CYP5035A6 pc.42.19.1 (genewise.42.13.1) Phanerochaete chrysosporium
HLIYKRWEPLRLSVTLTLLMGVPAALSVLLIPHLGLLRGALATFSLYLSTLISSIVAYRLSPWHPLARYPGPLPARVTQLWHTWQAHKGQQHLYLKQMHDKYGDVVRMGPNEISIRDADCIVPLYGPHGLPKGPSAGRQMHPQELSLIGYRDPARHSVRRKPWARGLGTAAVREYMPALRSRVSQLVDALGARSGHPVDLAEWIAFFAYVFVSDCSLSXLANCQSGMTLWATWRECHGAGAVFEQVPWLAYYAKMLPAISQRILKMRKLTVRHATRRYNSGSFSRDLFHYLSGEDLPEGSARPPQHIVAADGLLAVVAGSDTTASALSNLFYCIMRHRDVYKRLQQEVDQFSPLGDDSLDPQHLNNMPYLNAVINETLRYLPSVLSGSQRAPLIGGGGVSVGPYYVPEGNQVRVHFYSVHRDPRYFSDPDRFWPERWLIADDRQPSSEKIVHDDRAFIPFSYGPSNCVGKGLALQQMKSTVCHVMAKLEMRFADGYDPDTWEEQVQDEGVMIV
>CYP5035A7 gw.54.121.1 (genewise.54.12.1)
Phanerochaete chrysosporium
KSVHLIFKRYEPMHILVVSTLLLLLPAILTVPLIDQLGIAKGFLVAFATYFATLLSSITLYRISPFHPLARYPGPIIAKVSKIYHVAQVWSGKQHLYLQRLHDRYGDIVRFGGFSTCSLRGPNEVSIRDVSCIAPMLGTQGMPKGPGKHCWPEIHTLIGCSDIKEHQRRRRPWNRAFSTAAMKEYNPIIQKRLQELGDALAARQGEVVNLADWISFFTHVPWLSYYTRNIPGATNDEFRGMVFGQTVKRYACTGTTKDLFYYLNEDGAEKEDPPKPIVVVDGAVALIAGSDTTSTVLASTFYCLLRNADTYKRLQAEVDRFYPPGADSLAPDHLPEMHYLEAEALRLFPAVPSGSQRTPERGSGGKTIGPSYIPEGTQTRIHFWSVHRDPRNFSRPETFWPDRWLIADGLQKDEGVEFVHNPNAWIPFSLGPANCVGKNLALQEMRMVLVHLLHRFSFRFAGDYNPEQYEWDIEDRFVVAVGRLPVIVERR
>CYP5035B1 Phanerochaete chrysosporium
scaffold_247a
MGTEYVLPLLRTNILKLPTNMTRNDALLAVGGAAV
LCHLIFKKWEPTYIPAVVTLLLVVPLGLSALLVPHYGQLLAPLVALATYHTILLTSIALY
RLSPWHPLAQYPGPLPAKLSKWWMVWQERDCKQHLYIKQLHDRYGDIVRIGPNELSIRNV
DAVAPLMGTNGLPKGPS
LRGQGLEPPITGLIAIRDPAEHARRRRPWTRAFSTA
ALKEYEPILVKRISQLCEQLASQKGTLDLATWFSWFTYDFMGDMV
RFGGGSEMLAHGDQDGIWTMFKEGGE
GQMMYHHIPWLAHYAKRLPMSPALKKMRGFALGRTAERYKKGASTKDLFYYL
SNEDGVEKTPPPAAQVISDGVLATIAASDTTSTTLSNAFWNILRHPHYY
KRLQAEVDKFYPVGENAFDTKHHSKMTFLDAVL
NETLRMYPVLPSGSQRAPFPGNGDRVVGP
YYIPDGTQARIHFWSLQRDPRYFSHPDTFWPERWLIAEGLEPAPAGEKFVHNPNAFIPFS
FGPSNCVGKNLAQMEMRMVFCYLLQNLDFELDKSWNPAERENATEDQFVLLMRSPVQVTVRRRV*
>CYP5035B2 Phanerochaete chrysosporium
scaffold_144
MGSEVAMQLLRANISKPFPRLDQNDALAVVVGAALV
VCHLIFKHLEPTYIPAVLFLLVLVPLYLSALLLPHFGPLLAPVIAFTTYHTSLLTSIGLY
RISPWHPLAKYPGPLPAKLSKWWMVWKERDCKQHFYLEDLHKRYGDVVRIGPNELSICNV
DAVLPLMGPDGLTKGPC
STIGQGLEQPIPSLVSIRDPAEHARRRRPWTRAFSTA
ALKEYEPILAKRISELCEQLAQQKGSLNLATWISWFTYDVMGDL
VFGGGNEMLATGDQDGIWAMFEKSGE
GQMVYHHVPWLAHYAKRLPMSPALKKMREFALGRALERYKRGAVTKDLFYYL
SNEDGSEKIPPPPAQVIGDGVLATVAASDTTSTTIANTFWHILRYPHYY
KRVQAEVDKYYPPGESAFDTKHHNKMTFLEAVI
HETLRLYPVLPSGSQRSPVPGKGDRVVGP
YYLPDGTQARVHTWSLHRDPRYFSRPDTFWPERWLIAEGLEPAPAGEPFVHNANAFIPFS
FGPANCVGKNLAYLEMRMVFCHLLQNLDFELDKRWNPAERSRSAEDQFVLYMRCPLPVTVRRRV*
>CYP5035B3 PFF_271(pc.92.54.1)
Phanerochaete chrysosporium
MGAGYVPQLPRSYALTSFTGTSQTHALTPVIGAALITHLNFKRWEPLNLPIVIFLPLVAPLGLSALFAPGPSYGSLVAPFITLFLYHAILLASIALYRISPWHDLYHYPGPLPAKPSKWWMVWKERHGKQHLYVKALHDRYGDVVRTGPNEISIRDVAAVVPLMGTKGLPKGTAPWGEPIVPSVVPLIGIRDSVEHARLRRSWARAFTAGALKGYEPVLTARITQLIAKLGSQTGEXIDLALVLSYFSYDFMGDMLYYGGGSELLAEGDNDGVWALGQMTCHHLPWLAKYKDLLPASPGLQKMRSVALQRTMARYKNGGLGKDLFYHLSNEDSAEKTSPPTEQLVSDGVLAVFTASDTIATVLSNVFWSILRFPRYYEQLQAEVDKFYPARADAFDTAHYGEMVWLDAITNEALRLYPIVPSGSQRAPAPGDGARVVGPYVIPAGTNARVHTWSLQRDPRCFSRPDAFWPERWLAAAGLGDSEATCEGPEGAAGAAEDFVHDARAFEPYFVGPLDCIGRALAQLELRMVLCALLQRLAFAPARGDPLERERTLQDQFVVMMRGPVMVSVSWRA
>CYP5035C1 ug.43.44.1 Phanerochaete chrysosporium
MSAVLNSLSPTESVLAVVTCALATHLVFNRFEPTELPVVAAALVGLPAVLSALLVGHFGLLAGAALAFATFHATLAASIVLYRLSPFHPLARYPGPLPARITRWYWARVACGGRQHLELKRLHDVYGDIVRIGPNELSFRDISVVQPMMGAQGMPKGPMWDGRTFKPPILPLVGMRDVADHTRRRRPWIRAFTPAALKEYEPVVAKRGAQLIEILAQKKHTDFVHWIHLFTFDIMSDALFGGNPGAEMMSHEDKDGIMHSMKTGFEAGQLFEHIPWLGYWMRHFPQLATATKQYRAMCFQRGMQRYQDGSSQKDLFYYLVNEDGAEKQTPDKATVIADSALAIIAGSDTTASVFSNMVYCLLKNPHAYKRLRAEVDEFYPPEENSLDPKHHSKMPYLEAVINETLRLYPVVPSGSQRAPELGTGGTLMGTHYIPENTSVRVHFWSVHRDPRNFSQPESFLPERWLAAEGLEAPPAGLSGAPQDADSAAARGTFVHNANAYMPFSFGPWNCVGKALALLELRCVATHMMQRLDVRFADGWDPAEWDAAMEDKFVIKTGRLPVVVERRF
>CYP5035D1 ug.50.50.1
Phanerochaete chrysosporium
MITVNRPSTQDSVIATVACAIIVYFVCKRWEPWRLAVVVPLTMLPPLVLSLPLAASVGFLNAVITTSSTFASALVAMLTFYRLSPLHPLSQFPGPLQCKISGFWMAWIVSRGKRHVYIQSLHEKYGDYVRIGPNEVSINDPTAIPQILGSYGWPKASGMSGRALHQDPLPLISLLDDAEHSRRRKSWNRAFSSAAVREYQPVVAQRATQLVQALQEQRSVVDLSQWMRLPSDIAFVNLHDFLYSFGGGTEMLREGDKAGLWQLLKDGMSTAVPFEHVPWLSHYILHFPALIRSLTDLRALAFGRSKLRYERGSTTKDLFYYLVNEDHADAEMPPMKVVISDAVLAIVAGSDTTAVTLSNIFYYLISHPDTYRRLQEEVDKYYPPGEDALNPKHYVKMSYLDAVLNEAMRLYPALPSGSMRTPAKGSGGQVVGQRFIPEGTQVRVHPYTIQRDPRNFSYPNRFWAERWMIASGNQSHHEKIAHNPDALIPFSTGPRNCVGKNLALLEMKMVTCHVTQRLSLCFADGWDPSRWWDDLEDVFVSRMGQLPVIVRSR
>CYP5035E1
pc.97.5.1 (genewise.97.3.1)
Phanerochaete chrysosporium
MQAAHLVFNRWEPTNIAVVAALLLGVPCAAASLLFSGRGFVPRLALTAALYYACLGTSVVLYRLSPWHPLARYPGPWLLKTSKLWMVRRVKRGGQWRYIRELHQRFGDVVRIGGPNELSFCDAAMVVPVLGTQGLPKGPGLIALRDPLEHQRRRRTWNRAFKPAALQEYLPLIQKRTAQLLDALSKCEEQDVVDLGRWIRFCKYAHMPWLAQFTKHIPRVAAKLKELRAAARSRAAARYKAGANRKDLFYYLVGDSNEDGGEKEQPTEDVILSDALLAIIAGSDTTSTILTSAVYCLLTHPDVHKRLVEEVDKFYPPGADWCNTEHHADMHYLNANETLRLFPVLRDGSLRAPWVGHGDRALGPSSFIPEGTQVRVHTYSLQRDPRCFSQPDTFWPERWLVAGGLQHAEPGFVHEPGAFLPFSRGPSDCVGKGLALQDMRIVLCALLQHLELAPPRNRPFDEWKAEVDRRFADSSAVLPVSVRVRRRV
>CYP5036A1 Phanerochaete chrysosporium
AY866401
same as scaffold_57, PC-HN1
MDALDPRIAIPIVYFIYKKYEPSSPRSAFFLLLALPGVLVVALR
VCERFNSYATAVPTVYLAYWSLLSTFVVAYRISPFHPLARYPGPLLCKISKGWLAYVA
GKGGKAHLYVQDLHMRYGEVVRIGPNELSITHQDFTRVVLGAKGLPRGPYYDSRQHEA
GMSLDGMRDQALHAIRRRPWARGMNTAAMKYYEELIRNTLSDLIVGLKQRTNRPIDIS
EWTNYFGFDFMGQMAFTRDYGMLKNGYDKEGLLDLIEHAMQDSAWISHIPWSIPFLRY
VPGASKYWDQMKAVGERAVADRVALGSNHRDLFHYLMDEDGHEAVRPTKALVAVDGQL
AIIAGGDTTATTLSHIVYFLLRYPIYLDRLRKEIDETFPDGADSTLDFTKQTNMPFLN
ACINEALRLYPPVLAGLQRRVEPGTGGKMIGPYFVPEETQVSLFAYSIHRDPQHFSPL
TNTFWPDRWLSQEKYTLPSGDVISADEVVTNRDVFIPFSQGPMVCAGKNVALTEMRSV
MCALLQHFDLKIADQSFLDSWEDKIEETFTTKRGTLPVILSLRA
>CYP5036A2 Phanerochaete chrysosporium
scaffold_284
TVYVSYWALLVTYTIAYRLSPFHPLARYPGPLLCRISKAWLAYIVATSGKMHLYIQNLHMRYGDVVRI
GPNEVSVTHRDFIGVIGPKGLPKGP
YYETRAHKAGTSLNAIRDQALHSVRRRPWARGMNSAAMKYYEELVEETVG
DLVASLKRRTTKAIDFSEWMTYFGFDFMGHMA
FTHDYGLLKNGYDKEGLTPLIEHAMQ
DVAWVSHVPWSIDYLRHIPGVYKHWLRIKALGVQTVRKRIALGSTRRDLFYHLM
DEDNRERVKPDINVVAIDGQLAIIAGGDTTATALSHLFYCLLRHPQYLERLRKEIDDAVPIACGSF
KLDFSKLPAMPFLNAFI
NETLRLYPPVLSGLQRRVEAGTGGRFIGP
HFIPEQTQVSFSAYTIHRDPRYFSPLTDTFWPDRWLVQEQYVLPSGGVIPAAEVVTDRDVF
FPFSQGPTVCAGKTLALTEIRSVACALLQTFDISNADEASFDAWEDNLEEMFTTKRSTLPVFLSLRT*
>CYP5036A3 Phanerochaete chrysosporium
scaffold_78
MSAIFAASS
TTYIIFKRFEYSKPVPALVLLIGVPMT
LASVLRDHFAGLATAMCATAAVHWVLLTLFVAAYRISPFHPLARYPGPLPCKLSKCWMAY
LAGSGGKTHVYIDRLHRLYGDVVRI
GPNELSVRHKDACTTVLGAKGLPRGP
YYDTREHDNGVSLDGIRDPALHAVRRRPWARAMNSASTQYFEELIQHTVSDLTGGLK
ERAGESIDLTEWMSFF
FSYDYNMLKEGRDTQGLRRMIDQSLV
DLRWISHIPWSIPYLKMIPGASKNWDDMKAAGDKVARHRVSLGSSRPDLFHHL
RDEEGHEAVRPQLEVVSVDGALAII
AGADTAATTLAHFWMFMLRHPACFERLRKEVDATFARDDGPDFVKQARMPYLNACL
NETLRLFPPVLAGLQRRVGRGTGGRMIGT
HFIPEDTQVSLVAYTVHRNPDCFSPFPDTFWPDRWLTQETYTLPTGEVIPSSDVLTRRDA
FMAFSQGPMACAGKNVALAEMRAAVCAVVQRFDLVLAYERALDEWEEVLQECFVSKLGK
LPVQVVPRN*
>CYP5036B1 genewise.22.99.1
Phanerochaete chrysosporium
MALLQLAQDVFRRSHPASACYALYHKYLNKPVHPLYHFCLLLVVPAALLALLQAIHRISVAQECGYALFYWLVMASATVVYRISPFHPLANYPGPLAAKISKLYLAYLTAKGRAHEDVRALHSKYGDVVRIGPNELSFNRSDAIQTIYADKTMPKGPYYVARTNLAGVVQLDGVRDFKEHARRRRPWNKAMNSAAIKSYEPIVSSTASQLLGQLSKRIHNDVNISDWMSFYGFDFMGRMVFGREWGMLEEGRDVNDYWHTMDKCLTIVSWSSQIPWSVPIIRLMKPPPEVLKMQKISDDSAMARLTSEGSGVKDLYYYLLNEDDSSKSELTRDECISEGVLAIVAGSDTAATALTHLCYYLLTHPDSLQRLRQEIEEAYPTLGSELDDLSRQAEMPYLNACINETLRLLPPVLTGLQRSVTAGSGAIIAGYFVPEGVDVSVHHYSVHRNLQDFSPIPDTFWPDRWLEQDAYVLPDGDVIGKGEVRTNRGAFMPFSVGPQQCAGKNLAMVELRAVACGLFRRFDLSLSERMNICDYEKGLRDAYTTVRGPLYVKLKPRKE
>CYP5036C1 ug.36.48.1 = genewise2nd.119.1.1|whiterot1 = scaf154
47% t0
5036B1, 45% to 5036A1, 46% to 5036A2, 45% to 5036A3
not in tree Phanerochaete chrysosporium
MVDRVDPRLILGSSSLVSVACYLIYKHSEPNNIPAHAALLLGVPALLVHQLGTHWSILQQGGAFVAYWALILAFTGLYRLSPIHPLARYPGPTLGKLSKIYLSYLSARGDIYRVIKGWHDKYGDVVRIGPNELSFRHVDALQPIMGTKYTVKGPYYDTRTTPEQITQMDGIRDYSVHGQRRKPWLRAMSSAGLKGFEPIVKMKALELVEELSKKVGEIIDMSEWMNLFGFDFMGHLAFGREFGLLKSGNDHDDMIRTVEDGVYGAGVISHIPWIAFLVHFPPAMKGLRAMQQMAATFARERTQKGSTTKDIYYFLTEDEGAAQSGATHDEVIADGMLALIAGSDTTSIALSHVCYFLLRHPACAARLRAEVDRAFPPGEDVLDFARHADMPYLNACINEALRLLPPGLGGLQRMVRRGTGGAMIGPHFVPEDTKLSVHLFSLMRDAREFAPLPDAFWPERWLAQDTYVLPTGDAVSKEHVTTNRAAFIPFSVGPQNCAGKALALVELRAVTCALVSKFELHKPKDYDLDQWEGDLLDLYISIRGKLPVILQARQGR
>CYP5037A1 Phanerochaete chrysosporium
AADS01000003.1
minus strand, 45% TO CYP5037B2, 41% TO 5037B1
36346
MGVILLNTVDALSLVLVTYVLYLIGRALSRRATRTGRQVKPPGPPGLPFVGNAYQIPHDK 36167
36166 QWLRFDEWIRRY (1) 36131
36074 GDLVHISVMGQPTVIIGSAQTASELLDAR (1) 35982
35941 VLAGSIYSDRPQAVMAGEL (2) 35885
35823
VGWDQGLGYAPGPHSPRFREFRRLFQQFMGPRAAQDSSMLAAQEKSATRLLSRLLSTPEE 35644
35643 FITHVRQ (2) 35623
35568
VTGALILYLTYGYEVDEDGFKDPLVNIAEEAMLGFARASDPGAYLVDTMPWLKYIPEW 35395
35394 FPGASFKQDVKAMRQARERLYDVPYNFVQKAM 35299
35243 AEGPVPRSFVSTYVEEKATPAFADEELIKAAAASLYS
(1)
GADT (0)
35006
TPSSLASFILAMTLHPDVQRRAQVELDSVIGESWQRLPTFADRP 34875
34874 NLPYIDAIVLEVLRWHPAVPL (1) 34812
34758 GLAHRLSQDDVYRGYYFSQGTVFWANIW (2) 34675
34624
TMLHDEIIFPDPSRFMPERYLDEHGRLKSMSRFEDPAVIGFGFGRR 34487
34430
ICPGMHFAHNSIFIAIARMLYVFNFTKAVDKNGNEITPEVEYSGFIS (2) 34290
34239 HPSPFVCSISPRSIAAAELVVQSSHD* 34159
>CYP5037B1 Lentinula edodes (Shiitake mushroom)
GenEMBL AB116638
MALNVQVLTVLDLCFAVVGLIILRRIFGPKSLPLPPGPKGLPLI
GNILDMPTEKEWETFAQWGDAFGDICSVTVLGQPLIILSSAKVAVDLLDKRSSIYSDR
PVLQMGGELVGWKNTLVLLQYGDRFKRFRKLFHNLIGSHATMRQYFPAQELEAKKFLR
KVLAEPDDLQAHVRRLAGAVVLRISHGYEVQEHKDDPFVTLANSATEQFSLATSTGQF
MVDCIPALRHVPDWVPGADFKRKAKQWAATLIELVEQPHNFVKQQMLAGTASISFTSS
MLESKQLTEEEEFDLKWSAASLYSGAADTTVSAIYAFFLAMTLYPEVARKAQAEIDAV
VGNDRLPTFADREHLPYVDAVVKEVFRWNVVTPLAVPHRATQDDFYDGYFIPKGSLLI
PNLWKLTHDSRVYHDPFEFKPERFLADLLATEGLGRQVEPHPRETCFGFGRRICPGMH
LADTTVFACCVTSLAILDIDKCNENGVVIEPVNDQTSGTISHPKPFKCSIKPRSPKAV
ALVQSSDEQF
>CYP5037B2 Phanerochaete chrysosporium
AADS01000003.1
scaffold_164c 54% to 5037B1, GC bound at PIGPL
19304 MIRPLTLLDIALATLAVVLLKTIIARSKQRARY
19403 PPGPKGLPVIGNVLQMPKDREWLTFAQWGEQF (1)
GNIVYLSLLGQP 19582
19583
MIILNSAKDAVALLDKRSSIYSDRPILYMGGELIGWKYILGLTPYGDRFREYRRLMAKFI 19762
19763 GGKTQVERHFPVMEQEATSFLKRILRRPDDLGANIRT
(2)19873
19930
HAGAIILKLAYGYTIREDEDPFVTLADRAMAQFTEATTPGAFLVDVFPLLRHMPAW 20097
20098 FPGASFKRTAQEWSDTLNSMADVPHAFVKEQM (0)
20193
AKDTEVPSFTSELLRDEKLQEG 20308
20309 QEFNIKWSAASLYA (1) 20350
GAADT (0)
20465 TVSSIHTFFLTMLLFPHVQKRAQAEIDSVVGTDRLPTFEDRAKLPYVEGVLKEVLRWHPIGPL
(1) 20653
GLPHRLAQDDSYEGHLFPKGAIVIANIW(2)
20847
KCLHDPDVYPNPSDFDPTRHLSENGRSPQPDPRDYCFGFGRR (2)
ICP (1)
21085
GLHLADTSIWITCATVLAAFNIENVVENGRVIDIVPEYTSGTIR (2) 21219
21280 HPKPFRCSIKPRSTRAEALIFSD* 21351
>CYP5037B3 Phanerochaete chrysosporium
AADS01000003.1
Scaffold_164d 5 P450s on this sequence
12364
MPSALSLLDFAFAALGLIIVKAFLSRTRRQGPYPPGPKGLTIVGNALEMPTSREWLTFSEWGGRY (1) 12170
12115
GDIIYLSLLGQPMVILNSAKHAIALLDKRSNIYSDRPVLVMGGEMIGWKYTLALTPYGQR 11936
11935 FREYRRFIAKLIGGPTQMQTHLPLEEHETRRFLKRLLNEPERVADHIRK
(2) 11789
11728
TAGCIILKLSHGYDVREGHDPIVDLVDTATEQFSLATSPGAFLVDVFPLLRYVPAWVP 11555
11554 GARFQKTAREWRKVLERMADEPHDFVKQRM 11465
11412 AENTNVPNYTSELLQNERLDGDKEFNIKWSAASLYS (1)
11305
11252 GGADTTVSAIYSFFLAMTLFPHVAKRAQMEVDAVVGSDRLPTCEDRPNLPYVEALVKEVF
11073
11072 RWNPVAPL (1) 11049
10999 GLPHRLIEDDIYEGYFIPKGSFVIPNIW 10916
HILHDPNHYPNPFEFDPTRFLSDEGRTPQPDPRDYCFGFGRR (2) 10740
10688
RICPGLHLADVSVFLSCAMVLATFDISKAVENGKVIEPEVEYTSGTIR (2) 10545
10488 HPKPFKCTIKPRSTKAEALILSADD* 10411
>CYP5037B4 Phanerochaete chrysosporium
AADS01000003.1
Scaffold_164e 5 P450s on this sequence
9887
MSTPLTYLVLLSAILTVVLIRTAIARRKRWARLPPGPKGLPIVGNVLQMPKSQEWLTFSR 9708
9707 WAEQY (1) 9693
9638
GDIVYLNILGQPLIILNSAEDAVALLDKGGSIYANRPILAMGGELVGWNRTLALTQYGER 9459
9458
FREYRRLIARFIGGKAQMARHLPLVERETRRLLQRILNNPEDLAGNIRK (2)
TAGAIILTLS 9222
9221
HGYRIREDDDPVVAHVGRALEQFTEASTPGAFLVDVFPILRHVPAWLPGASFKATAKRWG 9042
9041 ETLEQMADVPHNYVKEQM (0)
8939 ASNKDIPNFTSELLRDEKLGDIDSKEFNIKWAAASMYS
(1) 8826
GGADT (0)
TVSSIHSFVLAMVLHPHVQRRAQAEIDAIIGPERLPTFEDRAALPYVEALFK 8540
8539 EVLRWNPVGPL 8507
8455 GLPHRLSQDDVYKGYLLPKGSIIIANIW 8372
8313
xxLRDHNLYPNPSDFDPTRHLPKNTEAASQPDPRNYCFGFGRR (2) 8191
8062
GQHLADASVWLACATMLATFDIENLVASDGTVIGVEPEYTSGTVR (2) 7928
7870 HPKPFKCSIKPRSALANALINAGMPE* 7790
>CYP5037C1 pc.2.111.1
(genewise2nd.2.36.1) Phanerochaete chrysosporium
MTSTNILLISHGHRVKDSNDRFLKLSDAVTDEFSEAVAPGAFLVDQFPLLRHLPSWVPGTAWRKTAEKYRRHVADAVAEPFAFVKQQMAAGTAIPSFVSRNLDDGAAPSPDHEHTVKYAAMALGCADAADAAWQTASALTSLFLAMTLYPEVQRRAQAELDGVVGTDRLPTFEDRDRLPYITAICAEVLRWMPVGPLGLPHRLTEDDVYEGYALPKGTIFFVNNWKLLHDPDTYRDPMAFMPERFLGAAPELDPSKIAFGYGRRICPGILVAEATIFITVAATLAAFSIRPAQNGGAPSLPPVRQTSGIISHPAPFQCDVVPRSKKAEALVVAAVENR
>CYP5037-un1 pseudogene genewise.25.75.1
scaffold_11 (1449124 bp) : 785586:787348 (1763 bp) (-) strand
32% TO 5037B3, C-term half = 40% to 5037B2
gray X = frameshift Phanerochaete chrysosporium
MLLRIWSRSQSFHPNVSALLFVTTRACHLMSC
RLPLPPGPRARWYGTIGMPTKSQWLNCHGRKCTVRYGSHYDAPGLLMYFHIVENPMVV
LDTAGTVNDLFEKRGTSYSSRPVTTMVNELYAYAQYSLGGYSLAH
(?)
WRKHRHLFHQHFNTSAMHVSRPVVLREAHTFLHNVSRTPVDDWSIVFGGH
(2)
ADAIVTMLSYGHQIAPEGEMYVDTRTRLSQ (0)
AYLLLLLAKTRTSL
IYDVVKHVPAWFPGAAFKKQALQWREANRMMLNVPLEKVQ
67 amino acid deletion here
QIDRIFASDKLPTF
ADREDLX
YVDCIVWEYLRWNP (1)
VTPLGLPCQVTEDDTYCGX
YIPKGATIVSNTWY (0)
MYPYLLLFDPDRFADASRNASLGIHELPNAAFER (2)
MCPGRVLAFETI
WITIATTLAGFHLSEPRDEHNEVIQLDTPNTPKLLS (2)
HPKPHQCAVSPRSERALFLVVESLDG*
>CYP5038A1 Nectria
haematococca
e_gw1.1.1095.1
Necha1/scaffold_1:4194871-4196497
41% to 532G1 new family in 53 clan, close to
CYP532 sequences
This gene model seems correct
MTTLRSNTIEQLRSALAHVTISYAVLFGISVLLLHLVS
NKYLTQLRRVPGPFLAGATRLWKLNFVAHGQL
EKVQMRLHARYGPVVRISPNEVLISDPSAIKTIYGHSSNFRKTKFYIPFGTKDNDDLFTDPDVIRHAHHR
REIASAYSMTSLVELEPMVDKCVETMCDQIRGLAGQRKPLDIAKWLQFYAFD
(0)
VIGQITFSRPFGFMQEGKDVQGCISKLERYLIHGALFTVMPEFWPLYYLANTLLSKIGLAYPPGIGIFNE
FVGSQIQDRLERGAQGQIDFVSRLQKMGRDESTIWRSCFANVAAGSDTTAISLRAIIYFLLKSPRAYHRL
QDEIDTFSAEGKVSNPVTFGEACKMPYLQA (0)
AMKEAMRLHPSVQWSLPRYVPDSGLQIGSFDIPAGTEVGINPYVIHRNMSIFGDDVEVFRPERWLEDEER
TKEMDRYMVQFGTGSRVCLGKNISLMEMSKLLPELLRHFDFELVHPEEPWTVSNF
WFAKQDDMDCFVTARKSNTV*
>CYP5039A1
Nectria haematococca
e_gw1.30.150.1
Necha1/scaffold_30:313862-315492
MGYLVLAVAAAVTYGVVVCVYRLYFSPLAKFPGPKIA (1)
AVTSWYNGYHDLVSGGQYIWVIEEMHRKYGPIV
RTRPDTIHVNDPAFIEKLYSQSPKHRRERHSTILGTMQADGSILATKDHDLHRRRRAVLNPFFSSQNVRR
LSPVINGILFNLLRRMEGWAKAGQPVKLNSAYRAATKDVIQAYALGDGEMCLDMEDCNAAFFDVFTPQRV
CHLGTHAFWLAYLMANLPPVIMTTLLPRVGVFATFMI (0)
NLNAEIDQIKQTDKLPEGKTIFHEILRSDIPSS
EKETLRLADEAMVLVIAGSETTASTLAAITYHLLADPSLMTRLRVELERVMPDVNEIPDPSTLNGLPFLN
ALIQEAIRLYPGASHRQDRVAPDEDLVYQRPDGQTFVIPAGTGVGMTAPLVNRNPDLYPNPLEFRPDRYL
ENPGLAAYQFAFSKGTRQCIGINLAYQELQTFVAGIFRKYDVY
(0)
LYKTKEEDVAIYSDYVTFGQYPGSQGLRVIIRE*
>CYP5040A1
Nectria haematococca
fgenesh1_pg.scaffold_24000105
Necha1/scaffold_24:251478-253220
MPMLQFFLSYSVAIGIALCAFY (0)
VIYKAKVALLGPLSDVPGPVVARWTNLVLKYHTLSGRRIQYLDSLFSRY
(1)
GTVVRVSPNEVGINSPDAVRIIQKVSGGFGKSAWYDMTGPGMLGMRDRGKHSRRRRLLAHPLSNSSLPA
FEPLIQAKVDLAMDQMETENRKLGYTDVHKWFSFMATDIIGDLTFGSSFRMLEQGR
(0)
RSQYVEDLQAVMPT
VHKRIELAPFFDMLFLLPLPQIRQVTARFQRIMSYGRESIRRLKLAQQAGTLITPFFFDKIMNPKDKENA
LTDVEMEEEAAELMVTGTDTTSNTLTYLVWSVLKDPAIRNRLEAEIGRLPGNFKDSDISKLNYLNAVVQE
SLRMYGAASGSHSRDVPRGGWEVGGYLIPDTATVLTQAYSLHRRPEIFPNPDM
(2)
FNPDRWLNATPEMQGSFIPFGGGPR (1)
ICVGIHLAYMELRLTTAAFFRKFRGATVHPSLTEDDMDLENYTLIAPKAHKCLIKL*
>CYP5040A2 Fusarium oxysporum
74% to CYP5040A1
FOXG_12072
MLSQSLAGYCLAACTALILYY (0)
AVAKVKTALYGPLSKIPGPAIGRWTNLVVKYHTLSGRRMQYIDSLFTQY
()
GPVVRISPTDVGINDADAVKVIQKVSGGFKKSAWYDKTGPGMLG
MRDREKHARRRRLLAH
PLSNSSLSNFEPLIRAKVDLAMSQMQNEYRSLGYTDCHKWFSFMATDIIGDLTFGSSFRMLEQGR
(0)
RSQYVDDLQAVMPTVNKRIELSPFFDLMFLLPLPQVKRFSERFQRILKYGEESIHRLQL
AQLTGSLDTPIFFEKIMNPKNKENALTDLEMQQEAAELMITGTDTTSNTLTYLVWSVLEN
PVIRTRLEEEVSTLPEHFSDADLVKLPYLNAVVKESLRLYGAASGAHQRDVPKGGWETCG
YLIPDTATVSTQAFSLHRLSNVFPSPYR (2)
FDPDRWLSLTAEMQDAYIPFGGGPR
VCIGIHLAYMELRVTTAVFFRKFRGAQVHASMTKDDMELENYTLIAPKSHKCLITL*
>CYP5040A2 Fusarium verticillioides
91% to CYP5040A2 Fusarium oxysporum
FVEG_10654
MMLSQSLAGYCLAACTALIIYY (0)
AVVKVKTALYGPLSKIPGPAVGRWTNLVVKYHTLSGRRMQYIDSLFSQY
(1)
GPVVRISPTDIGINDPDAVKVIQKVSGGFKKSAWYDKTGPGMLG
MRDREKHARRRRLLAHPLSNSSLPAFEPLIRAKVDLAMSQMEKEYRSLG
YTDCHKWFSFMATDIIGDLTFGSSFRMLEQGRRSQYVEDLQAVMPTVNKRI
ELSPFFDLMFLLPLPQIKKFSERFQRILKYGEESIRRLQLAQLTGSLNTP
IFFDKIMNPKNKENALTELEMQQEAAELMITGTDTTSNTLTYLVWSVLQS
PGIRARLEEEVSVLSADFKDADLVKLPYLNAVVKESLRLYGAASGAHQRD
VPEGGWEACGYMIPDTATVFTQAFSLHRLPEVFPDPHR
FDPDRWLRPTAEMQDAYIPFGGGPR (2)
VCIGIHIAYMELRVTAAVFFLKFRDAQVHASMTDDDMELENYTLIAPKSHKCLITL*
>CYP5041A1 # name changed to CYP684B1
no sequence
>CYP5041A2 # name changed to CYP684A2
no sequence
>CYP5042A1
Nectria haematococca
fgenesh1_pg.scaffold_37000024
Necha1/scaffold_37:64074-65768
MIDQVSQYLLRSSVRARIFALSLTITLLVFLVFVFVAQYFKPAGKRNLKDGRKSRLPPGPRGLPILGNLL
SLKDGRHDPNHAF (0)
LRQIASFGEMTTVHLGSKTWIFLNSHRTVSEIIAKRGSATNTRSPMPISSGLVSRDG
RSLVLPQESWTERRRVMHSLLSGTALKQYGEWQELESTQMMAEYLFKPEKWYKHHYRYANSVIHRIALGE
RLGKSTQELTDLQNCVTFFVGSIGSSVIDWFPDLAKLPKFMQPWRRHWQALGDWNYDVYNSWWAPIRKQV
EEGTAPPSFVRDVLLNKDTRYKGDDQDCMYVAMQLIEAGSDTTREALNIMVMAMLEYPGPFRKARNDIDL
LCGIGEQARLPVLSDMEDLRFICAIAKEVLRWRPIFIVTPDHVASQDIEFEGCRFPAGTGFVINEVAVGN
ECENPDMFYPERWMNGHETDISHGLWQFGGGRRICVGYRLAQRSLFINIARLIQCIDFKA
(0)
DGPYNGRILNQESTDEPFPVKATVRSREYERLIVEEATRAGVLDNAKIDRD*
>CYP5042A2 Aspergillus oryzae
AP007164.1d
Fourth P450 of six on this accession
CDS join(1201326..1201574,1201624..1202814,1202863..1203015)
63% to fgenesh1_pg.scaffold_37000024
MGASIHAHISAAANESPITAAFVSIAACLGLIFLIIQEIFKPVG
KRRSPQGKKWKLPPGPQGVPIFGSLLYLQKVREDEEHRIHKDLAKYGEMTTLHLGSKT
WILLNSKRVVSEIIAKRGSLTNGRSPMPIASGIVSRDGRSLLLPPAQWMEKRRVMHSL
LSGTAMKQYGSWQELESTQMLAEYLFQPERWYRHHYRYANSVVHRIALGERLVKSGKE
LAELQDVVTHFVGSIGTSLVDWFPELDKLPRMLQPWRKHWEKLGDWNEEVYKSWWIPA
REKVENGTAPPSWVRDVLLHPDTKFTGNDQEAMYVALQLLEAGSDTTREALNIFAMAA
LCFPDKFQKAREEVDSQCSTTKNFRLPGIDDLGNMPYICAMIKELLRWRPIFSFTPDH
VLTSDMEFEGYNFPAGVGFVINEIPVCNECEDPEDFKPERWLDGHETDAAHGLWQFGG
GRRICVGYRLAFQGLFINVARLVFCYNYEAAGPYDSKRLNHHKTVEPFPVKVTPRSEQ
HTSLILEEGARLGVLEDAKRLI
>CYP5042A2 Aspergillus flavus
100% to CYP5042A2 Aspergillus oryzae
AFL2G_06076
MGASIHAHISAAANESPITAAFVSIAACLGLIFLIIQEIFKPVGKRRSPQGKKWKLPPGPQGVPIFGSLLYLQKVREDEE
HRIHKDLAKYGEMTTLHLGSKTWILLNSKRVVSEIIAKRGSLTNGRSPMPIASGIVSRDGRSLLLPPAQWMEKRRVMHSL
LSGTAMKQYGSWQELESTQMLAEYLFQPERWYRHHYRYANSVVHRIALGERLVKSGKELAELQDVVTHFVGSIGTSLVDW
FPELDKLPRMLQPWRKHWEKLGDWNEEVYKSWWIPAREKVENGTAPPSWVRDVLLHPDTKFTGNDQEAMYVALQLLEAGS
DTTREALNIFAMAALCFPDKFQKAREEVDSQCSTTKNFRLPGIDDLGNMPYICAMIKELLRWRPIFSFTPDHVLTSDMEF
EGYNFPAGVGFVINEIPVCNECEDPEDFKPERWLDGHETDAAHGLWQFGGGRRICVGYRLAFQGLFINVARLVFCYNYEA
AGPYDSKRLNHHKTVEPFPVKVTPRSEQHTSLILEEGARLGVLEDAKRLI*
>CYP5042A3 Fusarium oxysporum f. sp.
lycopersici 4286 chromosome 13 cont2.710,
AAXH01000710
86% to CYP5042A1
Nectria
also gene model
FOXG_11943 revised
MISQITPYLSYAFERVPAASFLALSLCLAVLLLVVVAKYFEPVGKRRLRDGRKSHL
901
PPGPPGLPIIGSLHKLKEARGDPDHKYVSFLLSTVERLCRLSLLQLRELATYGEMTTVHL
1081
GSKTWIFLNSSRVVSEIIAKRGSATNTRSPMPISSGIVSRDGRSLILPQEAWME
1243
RRRVMHSLLNGTSLKQYGEWQELESTQMMAEYLFKPHLWYKHHYRYANSVIHRIALGERL
1423
GKSTQELADLQNCVTFFVGSIGSSIIDWFPDLARLPKFLQVWRSHWEALGKWN
1582
HDVYRSWWDPVRKQVENGTAPPSFVRDVLLNEETRYKGDDQDCMYLAMQLIEAG
1744
SDTTREALNIMVMAMLEYPEPFRKARADVDSICGVGEQARLPVLSDMDNLRFICAIAKEV
1924
LRWRPIFILTPDHVASQDIEFEGYLFPAGTGFTINEVPVGNEFEKPEAFYPERW
2086
MDGHEMDISHGLWQFGGGRRICVGYRLAQRSLFLNIARLVQCVDFKP (0) 2227
DGPYNAKILNLESVDEPFPVKSTIRSEAYEALIIKEATESWCFGGRAHGPGATIMMLFIVHTLVS
SLTRLE*
>CYP5042A4 Aspergillus niger
fgenesh1_pg.C_scaffold_8000113|Aspni1
82% to CYP5042A2
MSKSVHAQISGIAREYPFSATLVTIAAFLATIFLVIREIFTPVGKRRPPPGKRCKLPPGPRGIPIFGSLLDVRKVRDDQD
HIINNDLAKYGEMTTLHLGSKTWILLNSKRVVSEIIAKRGTLTNGRSPMPIASGIVSRNGRSLLLPPSGWTEKRRVMHSL
LSGTALKQYASWQELESTQLLAEYLFQPERWYRHHYRYANSVVHRIALGERLVKSGKELEDLQNVVTYFVGSIGSSLIDW
FPELDRLPRALQPWRKHWEKLGNWNEEVYKSWWIPVRDKVEQGTAPPSWVRDVLLHPDTKFTGDDQEAMYVAMQLLEAGS
DTTREVLNIFVMAALCYPRVFQKAREEVDRLCCTEGGLRLPGIEDLEHMPYICALIKELLRWRPIFVLTPDHVLTSDMEF
EGYHFPAGVGFVINEVPVCNECEDPEEFKPERWLDGHETDAAHGLWQFGGGRRICVGYRLAFRGLFINVARLVFCYNYAA
AGPYNPKRLNHHKTDEPFPVKVTPRSEDHVNLILREGESLQVLEDAKRRV*
>CYP5042A5P Neosartorya fischeri
59% to CYP5042A3
NFIA_005930
Note: this seq does not have an ortholog in A.
fumigatus
LTKYGEMTTVHLGSKTWI &
NSQRAVSEIFAKRGSITNGRSPVPVASGIVSRHGRSFIL ()
AMAALLFCYPEVFQKARAEVDRLCGTDKKKLRLPV
LDDMDQMPYTCAIIKELLRWRPIFPSTPDHVLTSNLEFEGYHIPAGVWFVVNEIPGCYESE
&
NPDVFKPEWWLDGHEADNVHGP*QFGGGRRICVGYRWAQRGPFGSLALRVFYYDYAA
()
SGPIDSRRLNHHFTQ &
EPFPVKVTPRSKQHAQLIIEEASREGILEES
>CYP5042B1P Aspergillus oryzae RIB40
AP007157.1h genomic DNA, SC023
complement(join(1170838..1170975,1171028..1172102,
1172148..1172220,1172254..1172488))
revised to match to 5042A1 and 5042A2 but stop codon
encountered
MTQLSIETFVVFTAFGLLWLSYEYFRPGSILSRFASMRSKLPPG
PPGLPIFGNMFQFTRARDAGLWGPFVSPGFLPSAASLRQYGPMTTLHMGFQTWVVLNGP
*VATDIINKHGKITS
ERPDMPIAGDLVSHGLRTVIRPTAAWTEGRRVMHHLLSGSVLRIYGNWQEIESLQML
SAYLREPKHWYAHHYRYSIAVLYRLVMGENLSKTQDELNDYQKVTMEITLSSLNSMVD
FFPRLDRWIPIYLQWWRPYWAKMGDFHHSVFKSWWDPIRDAVRQGTANPGFVRDTLLH
PDMRYKGTEEEAMYLATSVIAAGSDNTRMALNTFIMAMISHPETMARARQQLDAVCIN
EDGTLRLPGMADFDRLPYLAAMVKEVLRWRPTTPVTPQHQLTEDLEYEGYRFPKGTCF
VVNGIALGQVCDNPDQFDPSRWLDGNEGNIVHNLWAFGGGRRICVGYRVAQQALYVAI
ARIIFCFDLCADGPIDTRKLNHFHIHNEPFPVRVTVRSAKHEFLIKEEAEKASTAF
>CYP5042B1P Aspergillus flavus
99% to CYP5042B1 Aspergillus oryzae
AFL2G_04298
Same stop codon as in oryzae
MTQLSIETFVVFTAFGLLWLSYEYFRPGSILRRFASIRSKLPPGPPGLPIFGNMFQFTRARDAGLWGPFVSPGFLPSA (1)
ASLRQYGPMTTLHMGFQTWVVLNGP*VATDIINKHGK
ITSERPDMPIAGDLVSHGLRTVIRPTAAWTEGRRVMHHLLSGSVLRIYGNWQEIESLQMLSAYLREPKHWYAHHYRYSIA
VLYRLVMGENLSKTQDELNDYQKVTMEITLSSLNSMVDFFPRLDRWIPIYLQWWRPYWAKMGDFHHSVFKSWWDPIRDAV
RQGTANPGFVRDTLLHPDMRYKGTEEEAMYLATSVIAAGSDNTRMTLNTFIMAMISHPETMARARQQLDAVCINEDGTLR
LPGMADFDRLPYLAAMVKEVLRWRPTTPVTPQHQLTEDLEYEGYRFPKGTCFVVNGIALGQVCDNPDQFDPSRWLDGNEG
NIVHNLWAFGGGRRICVGYRVAQQALYVAIARIIFCFDLCADGPIDTRKLNHFHIHNEPFPVRVTVRSAKHEFLIKEEAE
KASTAF*
>CYP5043A1 Nectria haematococca
e_gw1.32.163.1
Necha1/scaffold_32:163700-165597
40% to 532C1, treat as new family in CYP53 clan
close to CYP532
This gene model seems correct
MADFLNTFQLQLQRFQLEKWEAPKLWELTGYIFLGFLILLAFDAIRSALRPGLRGLPGPAFARWTRLYRF
FLFADGDGPRKLLRLHKTYGPIVRVGPNHVYISDPKALPIVYPYSGRYAK
(0)
SDFYKAMAGRYEGKTLDNLF
TQQDSEAHKRLKVPVSQKFSASALRALEPMFHDCIDVFFDAMDDLAGQKIDLSTWLQW
(2)
FTFDAIAQLTFQRRFGFMEERKDVRNLIPATEGVVTYGALVGLIPELHRLLL
GNDVTTAILGWLMPSANAIGYIFQVSTLWDFIFK (0)
ITGEEMKRYDVEGGKDRADLLAWLKGEMNKGNTDLGPRELFTHISSNL
(2)
LAGSDTTAVALRAVFYHLIKNPNKYLKLQQEIDDAQAKGQLSEYIAFEESQKLEYF
(2)
QAVVKEAMRLNPSIVLPFERVVPPTGDTICGV
NLPGGTIVAMDTVVVHRDKATFGDDVESFRPERWIDSDPEQIKAMERAFFT
(0)
FGYGTRTCMGKNIALMEIGKVVPQTLRRYTLEWASDEPEWRVTSYWFGKQEGVIVKFRRR*
>CYP5043B1 Mgr033 Mycosphaerella graminicola
44% to CYP5043A1 Nectria haematococca,
40% to CYP5078A6 Neosartorya fischeri
MISSQLLPLSFVALALLWLGVRLQRLLRHDLRNVPGPFWAKVSGLYRLSMVKGGSAPAEYRKLHQKYGPFVRVGPNHVAVSDPSAIPIIYGLGSKFLKTDFYKTMVPSYDGKPMDSMFTARDPAIHKSLKTPVASLFAMTNMKNYEVYVDECTEIFANAMRDLEGQTVDLAIWLQWYAFDVVAGITFNRRFGFLEERRDVNQMIGQLDEGMDTVKVLGSYPVLDRPAKLLLRHVLPLLGRYDPLIKFVKMSEEEIARYDNSVKDASRTDFLSQLRQREEKLVAANGGGDAKAEILNHLSNNLLAGSDTTAISLRACFYYLIKTPRVTAKVREELEQQEQQGNISNPIKLEESLQLPYMQAVIKEATRLHPGVGFPLERFVPPEGATICGVELAGLTNVSMMAPVTQVDPTVYGEDAQSFRPERWLESNPEQLKLMERSMLVFGHGARTCIGKNISVMEMGKFIPQIVQKFDIEWASKNAEWKTNAAWFWKQTDMQVKFKVRK
>CYP5043B2 Aspergillus terreus
57% to CYP5043B1
ATEG_08967.1
MLQDIQLSWRALATCLVAVVILDYLRVYFRRGLRTLPGPRLAPFSSLYRLS
MVYNGAGPAQYRKIHEKYGPIVRVGPNEVSVADPTMIPRIYGIGSKFTKTPFYTSMAPIYQGEVMDSLFTTRDPAHHKFL
KSSVSQIFSMTNMKNFEIFADECTRIFMDAMLDLEGEPLDFSKWLQWYAFDVIGSLTFQRRFGFLEQRTDVDGMIGKIDI
GLQYVKVLGQFPSLIPFLQTISMSRPIQKLNIFPDTMDKFLKITEEEIKTYDNNNGTEKAQRTDFLAQLRAVESSRKLSH
RDMMNHLSNNLLAGSDTTAISLRAMFYYIVKNPRVYRKIQSEIDEADQKGLLSEFVTYEECLKLPYLQATMKEAMRLHPG
VGFPLERFVPPEGAEICGYALPGGTNVSISAPVIHVLKEIYGEDAESFRPERWLEATPEALKAMDRAFLAFGHGARTCIG
KNISIMEMGKFVPQMFRHFNITWASQRPEWETHAAWFWKQSGLILRLEKRK*
>CYP5043C1 Fusarium oxysporum
46% to CYP5043A1
FOXG_10831
MSLITEDKIIIILTVLLVGWLVSLVRTILRPGLGKVPGPWLAKFTQAWRIGLVWKGNAHEEYKSLHDKYGPIVRTAPNVV
DISDPTSIAIIYGISSKFLK (0)
SPFYQTLSVLYQNELMDSMFTTADPHEHKALKRPVAQKFSMSSLRTLEYLVDPCSDIFAKAMLDLQGQVVDL
GEWAQWYAFDVIGAITFSRRFGFMENRKDVKNIISGIELGLAYAGIVGQV
PSLHRYLLGNLTLRRILGRLGVPDPIAITTEASTEI (0)
MVSDCIREYDSQPYSSERADFLAYFRQEQKSTGQQMSQRDLMNHLMNNL
(2)
LAGSDTTGISLRSIFYYLLHDKSAYKTLQNEIDEADRAGKLSPTITFSESLGLEYL
(2)
QACIKEALRMHPAVSYPLERVVPPGGARLCGEYLPGGTIVGVNAAVIHRERDIFGQDADTFQ
PERWLHSSEERIKLMDRHNLAFGAGARTCIGKNISIMEMSKFVPQVLRQFDLEWASSEPGWRVKTYWFAKQTGLLVRFHR
RGKIRV*
>CYP5044A1
Nectria haematococca
fgenesh1_pg.scaffold_14000115
Necha1/scaffold_14:293544-295186
32% to 532C1 new family, best matches are all
CYP532, in CYP53 clan
delete last exon in model
MPVMIVFALGLGSCLLLVHLFTTYLRLSSIPGPFAAKFTDFWRFRSQNAKGHTQRLLALHQKHGKLVRIG
PNHVSISDPAAVPIVYSTNPTWHKGPSYYGAIPVSKNRAVPSIIGMGEAQHTAVRKSVGRAFTTNSLLDY
EDSIEATGQDLIKVLSRLQETDIGEWLQFFAMDMLIRIAFSDSLELLASGNDIDGTLAAVMGRFDHWGHW
GAVPSADYLFNKSRLATMLKGVGDSPLARVANRMLEARKRDTNKLSYKDLCAKFLEGQAKYPQLVQHDEI
LGIIMSTIGAGADTTAGTLTYTLYFLSKHPDVREKLVQEIDENLNAGMLSRMPKWAEVNRMPYLDAVLKE
SMRLLPIASWGLDRVVPPAGATIAGEFIPGGTIVGCQIDAVHQDQHVYGKDSATFRPERWLETGEDQRRQ
MDRAFLAFSAGKRTCTG
VHIAWLEMKKTLPLLLMNFE (0)
MDLVNPSQDVRDGIRVSAVKYPPPVPMKIRPRVAQNGV*
>CYP5045A1
Nectria haematococca
fgenesh1_pg.scaffold_43000032
Necha1/scaffold_43:94104-96134
32% to 548A3 new family in CYP53 clan
change the last exon
MSSLESTLDVHLPGQKFLVLIFAALCL (0)
PVVYNVLFHPLAQIPGPFLAKLSDLWHAYHLSTGTRHILLCDLHDRY
(1)
GPLVRIGPNTVSVNTNEGLQKIFSATSPIDKSPFYQAFAPGFHSSFAAVGDAFREKKSILSHAFAQ
KKLDAMEVTFMIHIKKLCEVMKSQKAVELDECLSALTIDILLDVCFGETFDLLSNPIEKSK(0)
EATLWRWPVLQKAIRILSSKYTTRDYPAQ (0)
RAIGAMLKQRQNASGREDIFNYLLTAEKPGSGEPFPDRELFGEAIILFVA
GSDTTSTALLTTLWHLLRHKHTYDNVVNEVRSRFKSIDELTYKEAQYLPYLRAVIEEGLRIFPPNSGFIP
RQVVRSGRPFILHDMEFPVG (0)
PVQTEIGVSNMSLHRNPLYFENPDQFIPERWTDGSKAKRDRPAFSPFSKGPRSCLGRN
(2)
MAYVEMTLVLAALFLELDMEFQDPATEARDGYRPTDSFVL (0)
AEEVVVDNNFISLSSL*
>CYP5046A1
Nectria haematococca
e_gw1.13.299.1
Necha1/scaffold_13:1007168-1008783
38% to 530A2, 40% to e_gw1.14.490.1, 39% to
530A1
59% to CYP5046A2
in the 64 clan
short at N-TERM, add exon
MKLVNHQDVVHLVRLQTQRLRSLDGGTLVPVVVVLILVLAGVYISLVPNSIT
(0)
ALILLTLPLPQDP
RRRKLPRGPPGWPLIGNLFDLSDQEQVRNKVREWHRKYGDVFYTKIGATDYIWLSSPKAVKDLMDKKSAI
YSSRPHLPLAQNIASGKSRQLFMAYGPEWRSLRKHSHALLNLNASKKYRPVQNLESKVVLHDLLTRPDQF
YTINRRYSTSVIMLVAYGYRVPSFEDPLITKIFSVLENLSIMMAPGAFAVETLPGLVKLPQFLFGNWRSW
GEKAFAHDSKIYLELWETLKRTTDAGTARDSFCKEFYLNDPKSKGIDDLLAAYTCGGLVEAGSETTATTI
NNWTLAMVLYPEIMKKGQEELDRVVGTDRMPQWEDEADLPYIRAMIKETLRWRPVNKFGMYHASTEDDWY
EGHFIPKNSVVVLNWW (2)
AIQRDPSRYPDPDTYEPARYLDSPLTAAEYMNSQDPYDRDHFSYGAGR
(2)
RACPGVHLAEKSLFIVISRTLWAFNIEKKKRADGTTVEPSTTMMTGFLSVPEM
FDCSITCRSDKHRRIIEKEFEGTKTDELIY*
>CYP5046A2 Phaeosphaeria nodorum SN15
AAGI01000373.1
MIQNVSLSPVLLKLSLLFISPVLLLLTAYFFIVPNVIK (0)
24919
DPRRRKLPPGPKGLPFVGNMLDLADTELVRDKAIAWRKQYGEIFYTKIGGTDYVW 25083
25084
LSSPKVVKDLMDKKSGIYSSRAPAPLAQDVASAGRRQLFMPYGARWRSIRKHSHDLLNLR 25263
25264
SSVKYQPVQDFESKYLLQELMESPDDFILINRRYSASVIMLVTYGYRIPSWNDPLIQRIY 25443
25444
AMLDRFTKMTAPGAHAIDSFPSLASLPQWMLGNWRSHGQRVFEQDSQLNLDLWNRLKRET 25623
25624
DAGTAKDCFTKTFYLKDPAKSGIDDLSAAYTCGGLIEAGSETTGTTLNNFVLCMLLNPEV 25803
25804
QKKAQEELDRVVGPDRLPTWEDEESLPYVRGVIKEVLRWRPVNKFGMPHATSEDDWYEGY 25983
25984
FIPKGSVAVLNWW (2)
AIHRDPELWPNPDAFDPSRYLNHSASAADY
26163
26164 INASDPKTRDHFAYGAGRRVCPGVHVAERSLYINIARVLWGFNLRKKIGKDGQVIEVTEK 26343
26344
MAPGFFSVPENYECDIRPRSAKHAEIMKKQWAEAEKEGLNF* 26469
>CYP5046B1 Trichoderma reesei QM9414
AAIL01000816.1
runs off end
47% to CYP5046A1, 51% to CYP5046A2
MSLLAKIALITPLVGSQNSPYSSHVQSNETFQILWLAYKLWTR
206456
DPRMKHLPPGPQGLPIIGNMLDMADTDKMMTLAKDWADQYGDVFYTKVGLQYFIWLSSP 206632
206633
TAVKDLMDKRGSIYSSRAASPMINMVSNQERLNFLPYGEKWRTLRNILHSALNLETSTS 206809
206810
YKPVQDFESKQALWEILHAKDDTEFSDINRRYSTSTIMTITYGQRVPHLSDPLYQDILKI 206989
206990 VRHFSLATAPGGWMIDTLPMLADIVPEWLLQNWKTVARQWYEEDSRIYLRMYHKLMNDIE 207169
207170
NGTAPDCFLKDMAREKIEKSLISDVTAAFAAGALIEAGSDATTTALNNVILACLLYPEVV 207349
207350
AGAHEELDRVVGSDRMPDFSDEPNLPYIRGIAKETLRWRASTKIGTCHSTTQDDWYKGFF 207529
207530
IPKGAVIVLNWW (2) 207565
>CYP5047A1 Nectria haematococca
fgenesh1_pg.scaffold_2000584
Necha1/scaffold_2:1870053-1871983
37% to 619A1, 68% to AAKE02000009.1 Neosartorya fischeri
in CYP64 clan
Neosartorya fischeri has an insertion between
PDRY and HEME not in this seq.
do not remove last intron
MNLSISLSFALIGLCAVIYRVLQIGKRDPRMPKGPPTVPILGNAHMLPTTGLYKK
(2)
MKEWTKTYGPVFSLKIGPSNTVVLCDRKAIHQLLVEKGSIYSDRPPSYVGKLLTQ
GDHLALEQMDVTWREKRKIISHNFSPKQLDENHFRVQEAE (2)
ATVLMSNLCNNPDNFYSEIRRYTASVVTSITYGCRAPTSDSFWCK (0)
GVYNVMDK (0)
WTAAMEPGANPPVDVFTWLQYIPSSFAFWKRRAIDAGKTMDGTWGEARRRVEERRAK
GEKRRCIVDTLLDEYEKKGWPSSIPQHAFTNLLGEIIEGGADTTAAQLLTLILAFAL
HPEVQTKAREEIDAICGTERSPRWDDFSKLPFINCIVKEGMRWRPV
(2)
AVTALPHKVRQ (1)
DDEYQGMLIPKDSTIFIPTWAIHHNENIYKDPETFDPDRYAQHPRLANDYAGSPDWANRDHYNYGAGRRI
CPGIHLAERNMWRIASKLLWAFEFAEPTDPKTGEVTHLDPEAYNPGILQAPLPFKVSIKPRSEAH
VATILREHEGSLEFLSQYS*
>CYP5047A2 Neosartorya fischeri
AAKE02000009.1 NFIA_047320
Note: this seq does not have an ortholog in A. fumigatus
49868
MSLLSTLLQVPGGAPAVSPILLLTGVL
49948
LVAGIWRLLQIGKRDPRMPKGPPTVPILGNFHQIPSTGLFAR (2)50073
50146
FGEWAKEYGPVFSLKFGPTNIIVLCDRKAVHELLDKRGAIYSDRPPSYVGRLLTQGDHIALE 50329
50330
QMDPVWREKRKVISHNFSPKNLDEKHFLVQEAE
(2) 50428
50485
GLILLNDLLRDTEGFYNHVRRYTASVASALAFGHRGPTFESFWGH (0) 50613
50687
AVYDVMDRWTEAMEAGANPPVDEYPILRLIPKRFAYWKRRAVAAGTVFDTTWGKARQIVDE 50869
50870
RRARGDKRDCIIDRLLDEYNQKGWPMSQHAFNNLVGEVVEGAADTTAAQILTLILAFA 51043
51044
MHPHVQEAARREIDAICPPDKPPKWSDFQQLPYINMIVKEGMRWRPV (2)51184
51261
AVTALPHRVRQ (1) 51293
51364
DDWYEGMLIPKDSTVFIATWAIHHNEQIYKDHDVFDPDRYKDHPKLANDYAGSPDW SNRD 51543
51544
KYNPSPLCLKTSSPV
SLHHYGYGAGRRLCPGVHFAERNMWRIAAKLLWAYEFAEPIDPRT 51723
51724
GKTIPLDPNSYNDGILHAPLPYKVRITPRSKQHEETIKKGLQEALDFLSKWN* 51882
>CYP5047A3P Fusarium oxysporum
(+) strand 57% TO CYP5047A1 Nectria haematococca
FOXG_04833
INVERTED DUPLICATION, two C-term P450
fragments face away from each other in a head to head orientation 88bp apart
1914
RNYTWYDGMLIPKDATVIIPSYAIHRSEQMKYTNPDTFDPSRYINHPRLASDYAGSPDFNNRD 2102
2103
HYGYGAGRRICPGMHLAERTQWRAIARILWAFDIELAVNPATGQKIVPDPEAFKEGIAHGPKPFKV 2300
2312 xxxxRSQAHIDTIFREAEQSLDEVAKWD* 2386
>CYP5047A4P Fusarium oxysporum
(-) strand 62% TO CYP5047A1
Nectria haematococca
FOXG_04832
INVERTED DUPLICATION, two C-term P450
fragments face away from each other in a head to head orientation 88bp apart
1826
DDYYDGMLIPKGSTIFVGVWAMHHDKDYYGSHDTFDPDRYLSHTKLANEYAVGPDYEKRD 1647
1646 KSIP 1635
1593
HHYGYGAGRRICPGIHLAERSMWRITAKLLWAFEFSEPIDPVTKR 1459
1462
KVQPLDPDAYTSANLVCPLPYKVNIKPRSVAHVEAIKRELESAEAFLSQYN* 1307
>CYP5047A4P Fusarium verticillioides
89% to CYP5047A4P Fusarium oxysporum = ortholog
FVEG_03309
TNVIVATATPVDLIPWLWYIPGKWKSCVYK
MRDHMDKVWSQARAMVDDRRARGDRRECMIDMKLDEYEKNGWPMSQHAFNNLFGE
LMEAGADTTANQILTLILALAKYPQFREKARVEIDAVC ()
GTERAPVFSDFAKMPYVNAIVKEGLRWRPT*VYLEHGI
DDY*DGMLIPKGSTIFVGVWAMHHDKDYYGSHDTFDPDRYLSHTKLANEYA
VGPDYEKRDKSISSTVLRATS*LPVL
HHYGYGAGRRICPGIHLAERSMWRITAKLLWAFEFSEPIDPVT
GKVKPLDQDAYTSANLVCPLPYKVNIKPRSAAHVEAIKRELESAEAFLSQYN*
>CYP5048A1 Nectria haematococca
fgenesh1_pg.scaffold_43000028
Necha1/scaffold_43:79608-81418
new family 31% to 503B1 in 54 clan
This gene model seems correct
MTVNALISADTPLALYAGILSFFTLAVVGFLSLRRERLPNAEFLRVVDKPGRGGQAEDVEAFMKNSLSTIMKGYNE
(0)
YSKHGRHFLLRTPTQIYLMAPSTMLEEIRKIPDNKLSQPAAANIIFQIKHTFHLALLNDYCHFD
VVRKSLTQNLPRIIGDLACETSYSFGAELGQCEDWTHAIVFQVCTALVTRVANRMMVGPELCRNKDLLHY
SATYTKATFDAAAMLRNVPAILKPLVMRFNTSHRSQQEVARRILVPVIRERLSRMHPNTSSGDKQNKPND
AHMSPSTPPNTAHGFRVSF (1)
KKRDPEILLQRMIHINVTAIHAPAVTLAECIFDLCRHPEIHAELRDEIIQV
LGNKAFDEAWSKANVDKLVKLDSFIRESTRLTPMSA (1)
VKMERLAVQDFKFSDGTFVPKGTSIGVISHGRHLDCDILPNATTFDAFRYAKVRAELGKEKQYTFAQAGPDNL
LFGLGIHACPGRHFASVLLKIMLAHVLVCYDIRFIEGLSPPHGTWTQKFRNPDLGYAVSWKGRKVDTELQGAFL*
>CYP5049A1
Nectria haematococca
e_gw1.23.313.1
new family add N-term exon in the CYP59 clan
Necha1/scaffold_23:325069-326664
MDLLDKLTAYAVQRPVFVSAWTLTVALVLNVIYKGYRQRRFYRNL (0)
PGPPHSWLFGHLKVMGEMSALVPPNCHPQLYFTEMARRYNLDGIFYVDLWPVGPGSCLITDPDLLDQITVRK
ILPHHPMAEDFLSPMIGRGSIGGANGALWKRLHNAMNPAFSWTHIRHLTDVFVDECVQFRKNLDKLAQTG
EVFSMEHVSARLIFDVIARIVFNFPLHAQTTGSQDLEDLRELILLVEGQSDITIAYNPVEQIKRWWRRRQ
VLGRLHPSILSKIHERFELLVNEKIVPSRKDPNSILDLMLREHVDQEGMTKANAKLSKADVNLL
(2)
IKALLVGGHGTTTDTLC (0)
YMYMLLSKSPHVVEKMLQEHIEQLGPDTEVSTQTMVETPELLQKLPYTDAVIKETLRMF
PVGYGVREGPPGAKVTYKGRDLPVDHGVAVSTQGHDVHYNTRFFPDPTVFRPERWLGPEEIPRSYFRTFG
RGPRACLGQNLAANELKVILVMTVRDYSFECAGLKPNDKPKMTYTDLDTVYGDIVFQELGLEAKPRGGMM
MTVKKRA*
>CYP5049A2 Fusarium graminearum = Gibberella zeae
AACM01000320.1, AACM02000262.1
49% to CYP5049A1
252033
MSVSEFKAPGLLMTILSAT
251976
ALLIAVLYRGYRTRRFYRDL (0)
PSPPHSWLLGHISILKNIALSMP
251797
251796
RNSMPQLYYTEIAHRYKHEGIFYLDLWPIGPSLVIITDPKLIEQAHIPRPMVPHPFTNTS 251617
251616
MAPIAGDDIIPTKSGTEWKKLRNDMSPAFSYTYAHNMVGVIVNESKLLRGKLDELSATGQ 251437
251436
VFSMEELLNKTIFGTVSRHLLNDESYAQKAGRQDLADMRELIDLAREESDPRIAYNPLVQ 251257
251256
IPRRMKRYIIRRRLEASLFGVIYKRLETLVSGGIVPSRQTPTSVLDLILREH
AELAKRENKEGRCNFANLSKFEEKQLLT (2)
IRGLSLGGHTTTTTILS (0)
YLFMLLSKAPHIVDKMHQEHIQQLGPNPQATLLKNPDILSK 250729
250728
LPHTEAVIKETLRLYSVGSGLKLGPPGATVYHQGRHLPIDNNLIIVTNAHGIHYDPNIYS 250549
250548
QPIDFRPERWLSQNKAHPRPGYFRPFGGDGRWCPGQNIAMCMLKVIVVMTIGDYVFECAD 250369
250368
LKPNLKPGTLHTDVDVVFGDIAFQQLLLEGRPRDGMMMTVRKRVQDLTLT*250216
>CYP5049A3 Fusarium oxysporum
52% to CYP5049A2
FOXG_04077
MAVTNIITGLPLRMPGPILVTALAACLIIVILYRGYSHRRFLSRL (1)
GPPHSWLFGHIKVFGQVAASMPPNTHPQLLYTEI
(0)
STYTTLKEIFYLDLWPIGPDMVVITDPKLMGN
SSRPKPLPIHPLTAVFMKPMLGEGTMAATNGALWRKIATAVSPAFSMGHVLGMTSIMADE
CLLFQEKLDELAVTGDVFSMEELIARLAFGIVSIVTLGEPQHSQAVGSQILKDLRDLVNL
AGGETNPLIAYNPMVQIPRRWKRHRIVSRLDSSLRQRVNECVERIVQEGDVPSRQNPRST
MDLLIHEHAEAMLDERKGGVYGRLELSSSEEEMIFSK
(2)
LKTMLLGGHSTSTSTLC
(0)
FLFILLSKAPDVVEKMHREHIEQLGASPTVTL
LDNPSMFRRLPYTEAVIKESPRLYPLGSDLKQAPPGTTITTHDGRRLPNANGLIMTASTH
TIHYDANIYPDRTSFRPERWLDPEKAPPEPGYFRAFGGDGRACSGQNMGMNMLKIVMVIT
MGKYTFECAGLAPNKETRTKHTKFDLVFGDIAFQQLGLDGRPGDGMMMTVRKKA*
>CYP5049A3P Fusarium verticillioides
76% to CYP5049A3 Fusarium oxysporum = ortholog
no gene model
GPPHSWLLGHS
KVFSQVAALMPPNTHPQLFYAEMVRLYNLKEIFYLDLWPIGPSMVVIIDPKLMDNSTLPK
PLPIHPLTAVFMKPMLGEGTMAAINGALWRKIAAAVIPAFSMSHVLGITSIMIDECLLFQ
ERLDKSAVGGDVFSMDGLVAKLVFGIVSTVTLGESQHAQTVGSQILKDSRNLVNLARGET
DPLIAYNPMVQIPRR*KRHQIVRRLNSSLREKVDECVE*TVQEGIVFSRQNPRRLM
()
TRDASWCEHAEAVLEQKQRGVHGRSQLSESE*EILFSK
LRPMQLGGHSTSTNTLC ()
FLFMLLSKAPDVVEKMH*EQIEQLGASPQVTLLSNPNMFRRLLYTDA
()
RLYPLGPDLKHTPPGTTITAHDGRRLPIANGLIMTASPHTIHYDAHIYPDPAAFRPERWL
IQEKPIPGDYFRTFGGDGRTCPGQNMGMNILKIVMVMTMGKYTFECVRLKPNREPKTK
HTNFDLLFGDMAFQQLGLDGGPRNGMMMTVRKKA
>CYP5050A1 Nectria haematococca
fgenesh1_pg.scaffold_13000347
Necha1/scaffold_13:996526-998270
45% to CYP5050B1
36% to e_gw1.13.299.1, part of a P450 gene
cluster, in the CYP64 clan
36% to 530A1, 41% to CYP5069A1
Aspergillus fumigatus
This gene model seems correct
MAVLGYAGLLVLLVACIYLRGRGRGKLPPGPKGIPLLGNAYQLGSKPHRQLQLWASQFGSVFTVRLGWES
WVFINDPPSVREIFDKQSAVTSGRMPQPVLSGILSGENRLLLLTYGEKWRKLRAIVHKSLTPKGSSTYKP
GQEFEAKQLIYDIATDNATQEDFYMHVRRYTTSVVLLSTYGLRVPSW
(0)
DCDDIRAIYGLLHDFSQAAQPGAYLADLIPPLGNLPWFLQWWRPSATRAYKKQRDTWMGYWKRLQVALKE
NRAPECLVRQLVESDLKKQGISEVEAGFAAG (1)
SMIEAGSETTSSALNSAILYLSAHPEVQDIADEELSRVVGDERSPTFDDEADLPYIRAIGKE
ILRIRPVTNIGTPHYTTADIEHKGYIIPKNTVVCISQYVLHFDQGRWKEDGGRSFDPSRYLAYPEKAGVY
AASRDANSRDHFDFGAGRRICPGMHLAENSLFITLAKLLWAFRIEPGQGPDGKPIPVDLSDDAYEPGVNT
LPKPFKARFVARNETRARVLHEEWAVAQEQGFWLGDVKVDTKGVVVQDSV*
>CYP5050B1
Nectria haematococca
gw1.19.97.1
Necha1/scaffold_19:553881-555574
45% to CYP5050A1
add to N and C-terminals
MLVRSYFSTVMSQEILLPIILGLVFLFIKFVGFSKQTSKP
IPGPPALPLIGNLLQFKSPSILKTWARQYGEIYQVRLGPAXNWVFLNSPKIVKELLEKKSAATSTRPSFL
SANMVSGGRRMVLMPYGNHWRTLRSIIHASLTPKAANVLQPAQNFEGKQLIWNIFNSINNT
(1)
EMGFYTHVQRYSASVILLMVYGLRAPTW (0)
ESNAITQIYKVMNDFGRVANP (1)
IYGAIDVFPWLLNLPKWMHWWNNDLKKIEE
RQSEAWLHYWNQMKDKIDKGEAPDCFGRQFVEAGYKQKGISELQAAYVCG
(1)
TMIEAGSDTTAASVNNGLLY
LSAYPDVVARAHEEIEHVVGNNRSPTFDDDLPYVRAIVKETLRIRPATTMGGPHAADQDIEYNGYTIPKG
TGLMLHQNGIQMDPELYPEPEKFNPDRFLDHPLKAGDYVGIADPYKRDHWTYGTGRRICSGMHVAENSLH
IVFAKILWAYTISAPKDEEGRLLPVDLSDDAFFLGAVTVAKPYRCIFSPRNAEVAETIVREWKEAEREGF
QLGDRKVGIDGIIATQTD*
>CYP5051A1
Nectria haematococca
fgenesh1_pg.scaffold_8000422
Necha1/scaffold_8:1042988-1044138
MLEHLSFLRIFLSLVLIGVVIIIRRLYWHPLSKFPGPALPALTSFYQFYIFWTHEEGNWYSELHKKY
(1)
GPVVRCGPNHLSFNDPSMVSTVYHSKVDKTGFHQEFSCPAAVFNKKSHMDHAVAKRRFAHA
(0)
YSLPRVQLLEPALDDQVVRFMSNLTAESKKDPLVDFGTWIR (2)
YFSFDVITAMSLGTPVGFMDAKDDVRGLIRNMEETAVREQRLSLFPPISAFARNNPLGRRLFVSSPSDRRGLGVFMA
(0)
EIRQEVQQRRACTAKPTYEHSMLDQWLASSSSDGQGIPQQEIEDELLMDM
(2)
MAGPDSIALMATNLIFLVADQR
PILQRAQAEVDAAYADGRLSGQVPTYEECRQLPFITACVNEGLRFVASTFPRRRASPPGRPFSLNGMHVP
PGTSVSSSAAMIGRHPDLYGDQADQFLPDRWLAASPEQLQEWARLDVHWGVGVRKCLGKHVGLMALYKTLVT
(0)
LVRSFDLQLEETTTIDRWSYPSSEHMLLTPHVPPTQ*
>CYP5052A1
Nectria haematococca
e_gw1.70.16.1
Necha1/scaffold_70:45730-47558
new family 44% to CYP5052C1
Aspergillus fumigatus with two introns removed
48% to in the CYP64 clan
This gene model seems correct
MALLQSPLSRGAPSIASIVGVAVICIISWFIWKLVEEKRFERRYRLPNLVPGLPLIGNG
HQIPPGGTVLHFQKLAKQYGEM (2)
FTVKIGGVYWLFLNSRRVSNELLDKRASIYSSRMSLPMANDLISNQKRIVLMPYGDLWR
RERKVMHQILNGTRTRLFEPYQDTESKALLFNYLQSPQAWFKAHATFSGSIIMSVVFGRRAGLEDPNLRE
SLAVSEKFVPYLVPGASLVDHLPFLARIPWLKSLQPWRWYGDYLYRRTKT
(2)
VYKREMDDLRGRMKSGSYKPCFMSEFLNLGHDQEFEDDDLYFIAGALMEAGTDTTRVSLDQIVASVVLFP
DWAERARKELDEVCGPNAERLPTAQDAPKLPRIKAAVKESVRWK (2)
PIIAETGIPHALTRDDEFEGYRIPAGTVVNYNHWAISNDPAQYEQPERFWPERFMDEDLDKPLQGHLGFGA
(1)
GKRVCVGYSVGNTNLFIAIARILYCFDIQGADDTPIDTSKPLYAIDSQPPFKVHVKPRTEAHAELVRRECSDAVVK*
>CYP5052B1
Nectria haematococca
gw1.142.24.1
Necha1/scaffold_142:12270-13802
48% CYP5052A1
add cyan at N-term and C-term
MKLLEGQSLTLPVVSALLLLWLLYRTILFFRFHHKYNFPNLVPGVPLFGNMLQIPTDTAERRLYLHKLAKKYGEM
(2)
FTLKVGSNYWVFMNSQRVANEILDKRGARYISRQNLPMPGDVASGGKRVVFMPYGNLWKX
ERKVIHEIIGPRNRNVFAPLQDVKSRALLHQYLTEPDLWNQAHARYASSLIMSMVFGRRT
KLGDPNVDRIIETNNEIMKMFEPGSNLIDSFPFLASIPLPRSIQPWRWWGDSVFEQSKK (2)
NFMEEFESLAERQRQGKDVTCFVSEFQRLGRDKSLDYESTVFLAGSLIEARSDTTRM
ALNQLMAGAALFPDSVRRARQDLDEVCGANAERLPVASDIADLPYIKAVSKEVLRWK (2)
LTYISSISFPEIAHSLIEDDSFEGYNLPAGTNVIWNSWGVHMGGSEYEQPERFWPERFLNEDLDKPLKGHLAFRA
(1)
GRRVCPGWVIASNSLHLLIARVLYCFDFHTVPGHPIPVGKPFEISTEKPYEVKVTVRSPAHAALIQRECTEAANIE*
>CYP5052B2P
Nectria haematococca
gw1.36.29.1
Necha1/scaffold_36:100410-101927
88% to CYP5052B1
50% to CYP5052A1
add
cyan regions. Note probable pseudogene. 3 stop codons and 2 frameshifts at X.
MELLEGQPLTLAVGSALLLLWLLYRTVL*FRFHQKYSFPX
NLVPGVPLFGSMLQIPADTAERRLYLHRLAKTYGEM (2)
FTLKVGSNYWIFMNSQRVTNELLDKRGARYISRQNLPMPGDVASGGKRVVFMPYGNLWKWERKVIHET
IGPGNRNVFAPLQDVESRALLYLYLAEPDLWNQAHARYASSLIMSMVFGRRTKLGDPNIDRIIDTNNEIM
KIFKPGSNLIDSFPFLA STGIPLPRSIQPWR*WGNSVFEQPKK (2)
NFAEEFEGLAERQRQGKDVTCFVSEFQRLGRDKTLGYESTVFLAGSLIKARSD
TTLVALNQLMAGAALX
FPDSVQRARKDLDEICGANAERLPVASDIASLPYIKAISKEVLRWK
(2)
LTSFSSISFPEISHSLI*DDSFEGYNLPAGTNVIWNSWGVHMDASEYEQPERFWPERFLNEDLDKPIKGHLAFGA
(1)
GRRVCPGWVIASNSLHLLIARVMYCFDFHTVPGHLIPVGRPFEIGTEKPYEVKVTVRSPAHAALVRRECSEAANIE*
>CYP5052B3 Fusarium oxysporum
84% to CYP5052B1 Nectria haematococca
FOXG_01376 revised
MKLAGRNIQVVPIAIALALLWILYRTVLWLRFHRKYKFPNLVPGVPLFGNMLQIPTDTAGRRLYLHK
MARKYGEMFTLKVGSNYWIFMNSQRVANELLDKRGARYISRQNLPMPGDVASGGKRVVFMPYGNLWKWERKLIHEIIGPG
NRNVFAPLQDVESRTLLHDYLTEPDMWNQANARYASSLIMSMVFGRRTKMGDANVDRIIETNNEIMKMFEPGSSLIDSFP
FLAYIPLPKALQPWRWWGDSVFEQSKKNFSEEFEGLAARQQQGKNVTCFVSEFKRLGRDKVLDYESTVFLAGSLIEAGSD
TTRVALNQLVAGAALFPDFVQRARQDLDNLCGADAQRLPVASDIASLPYIKAIGKEVLRWN
(2)
ISFPEIAHSLIEDDSFEGY
NIPAGTNVIWNSWGVHMDASEYENPEIFWPERFMNEDLDKPIKGHLAFGA
GRRVCPGWVIASNSLHLLIARVLYCFDFHQVPGHPIPVGKPFEIGTEKPYEVRISVRSAAHAALIKADCSEAANF*
>CYP5052C1 Aspergillus fumigatus
XM_749573
MSDPNTTAVRPVPRVGFATIVLGLIVLGILRWAYACYKWNQKYK
LPARVPGIPILGNSLQVPAVQQGPWAKDLAAKYGEM (2)
FTCQFGGSTWVFLNSSRVVKDLLEKRAAIYNSRPPFPMTQDIISRGGRIVLMPYGER
WRLVRRVMHQILSVTNQPMFQPFQDLESRQLFWDYLHKPDRWFAANGRYANSVIMSVV
FGRRSLLDDPDVAELFETIELFLAEQQPGGESGGCVPGAGELAPVLAVVAAAGRSGFS
RRPSSRQTGTTNPRRYEAKMLRGEFLASKEITQMDEVTKLFVFGSLMEAGSDTSRVTL
GQIIAGAITYPDWVTRAREQLDRVCGAHAERLPGWDDRPRLPYITAVVKEGFRWRPNI
AEIGAPTVLIKDDEYEGSRFPKGTVFTWNAWAIALSPDEYEQPERFWPDRFLNEDLEN
ALKGHGAFGP(1)
GRRVCAGWKVGETNVWIAIARLLYCFDF
HPVPGQPIDTMRIPQLAGNAASFAARVSVRSPAHAELIRRECAEAVKTQY
>CYP5052C2 Nectria haematococca
gw1.15.527.1
Necha1/scaffold_15:823081-824500
53% to CYP5052C1 Aspergillus fumigatus
47% to CYP5052A1
add N and C-term parts
MSYSYTADLLPFLSKHLPAQVKLGPLFILLIILTFVTKQLFASWQWHRKYKLPSRV
PGLPLLGNTLQVQYPAGMWFKGLAEKHGEM (2)
FTMQLGSKTWVFLNSSRVVEDLLEKRSAIYSSRPRFPMAQ
ELMSGNNRFLLMPYGERWRKIRKIMHQILSTRQANKFQPYQDIESRKLLHNYLRKPXLWFRANQLFANSV
ILSVVLGRSSNLDDPTLVELFDSAQTFLCNIEPGTNPVDLFHWLASLPSWMQWWRSYGMSGFENTRR
(2)
IYLREVNLIKQKIADGTAKPCFAVDYLQAKGDINTDDDEQLFIFGTLMEAGSDTSRIAIGQCIACAAIYPEWV
KKARAEMDAVCGNAERLTSFEDRDKMPYMTAAAKEILRWRPFIQGGTPRELIQDDEYEDYKFPAGTVFTW
NPWAIALNPKEYDDPLTFKPERFLNDDLKNPLKGHWSFGA (1)
GRRVCAGWNVGDTNVWIASARLTYCFDFEQVQ (0)
GQPIDTFNTTWEVHNHPAFPIEIKPRSPEHAALIERAFAEIVED*
>CYP5053A1
Nectria haematococca
gw1.7.200.1
Necha1/scaffold_7:1738381-1740021
42% to 546A2 M. grisea, 40% to 546A1, 35% to 546B1 in the
CYP64 clan
37% to 546B2, 55% to AAGI01000022.1
Phaeosphaeria nodorum
add to the ends
MALSSYLKQTELSKDFLYIYGL
LALLASPLIWLAADYVRILRLRQKMPPGPFPLPLVGNFFQLPKHQPWIEWETWSDTYKSSMITIWNGRRP
VIICNDIWSISELLDKRAAIYSSGPHHVVMGDMMNMSETNQVCQKYGDSWRLHRRLM
(0)
HTIVGSQSVRNHR
SHQSNESKVLLRDMLLSPDDFDMSIERYSCSVVSILGWGRRIDRINDTVAQVALSFMEGVNFVVPGLYIM
EAVPWLAKLPGWLYPLPSIILKSSKHMQRYFAALAKEAAANSTEDNFSKSLLVAQREHSISDEDISSLTA
NMIGGGVDTTTSSTLTLILAMCVFPGVQRKAQEELDRVVGQDRYPEWTDEENLPYIRAVVSDXLRWRTVT
ILGGIPHAPIRDDEYNGYFIPKDTAITGNLWAIHRNPREFPRPDVFRPERFLDGLERPYPNKKGHNAFGW
GRRQCSGQPLAEQGLFITIARMIWAFNMQPGLDEN (0)
NRPVKLDIFAHSDCENMRPEKFKARFTPRTQQIKDLILREAAEARELLRPLDGETAITMASVA*
>CYP5053A2 Phaeosphaeria nodorum SN15
AAGI01000022.1
304178
MLLDRLGYEANT
304142
FYYAATACLVLATVVVFVDYGRMLLLRRKLPPGPFPFPIVGNHYQISKDRPWLQWAEWAE 303963
303962
YYNNPMTTIWVGREHRIIVQDAWVASDLLEKRADIFSSRPRFVVMGDLVDATTTNQTTLV 303783
303782
YGDRWRIHRKLM (0) 303747
303691
HGVVGTQAVRGYREAQANESKILTRDLMMKPDDFVMSI (?) 303578
303576
ERYSVSLTSIIGWGRRIKKTNDEVAQLALAVMEAVNYIVPGLYLMEAIPILSKLPSFIYS 303397
303396
TPSKIKAGANLFSKYFYFLTQEGAKVDGPTFAANLIEAQPKMNLSNKEVSGLAANLIGG 303220
303219
GVDTTSSTMLSFILAMAYFPDVQKKVQAEFDAVVGHDRSPNWDDVDKRLPYLVATVKEVL 303040
303039
RWRTVTILAGIPHANTVDFEYRGYHIPAGTNITGNMWAIHRNPRDFPDPDVLRPERFLNG 302860
302859
LEKPYPNQRGSNPFGWGRRQCSGQPLAEQGLYYSLARIAWAFNIQPGLDKH (0?) 302707
302636
GNEVKLDIFAYTNTENMRPEPFEVRFSPRTPKIQDMILSEAMIASEDLSIYDWETK 302469
302468
VTIKDALQDA* 302436
>CYP5053A3 Mycosphaerella fijiensis
58% to CYP5053A1 Nectria haematococca
e_gw1.16.154.1
MGLHFSLYTIFVLIELAVEALTALGILWLAIDYLRVLWLRRRLPPGPFPLPLIGNHLDMRMQRPWRHWEKLSFEVYKNP
MITLWNGHRPVICCNDAWTISDMFEKRATIYSSRPRMIMMGDVINTTKHNQVCLKYDDQWRLHRKLSHSVVGTQVVRAYR
GFQSSETKILLEDLLTRPDNYVPAIERYSCSIVSIVGWGRRIKDTNDPVAQRALESMEVVNAVIPGQAMMEMMPWLLELP
SWINPLPKLICAVGDRLNTFWQEMTEEAAATSEDEDLFSKRLIKERDAGTINARELGNLVSNLIGGGVDTTSSSMISFIL
AMCVFPEVQKKAQEELDRVVGRSRIPDWGDEDSLPYITATATETLRWRTVTTLGGIPHAPTQDDEYRGYHIPKDTWIVGN
VWAIHRNPKDYPDPDGFRPERFLEGSEWYRPHPSKKGHAAFGWGRRQCSGQPLAEQGLWLVTARFLWAFEIKPGVDEEGN
EVKLDIFAYTPSENQRPEPFSVRFIPRSPEIRDLILREAERAREELKRFDGETKVRMS*
>CYP5053B1
Nectria haematococca
gw1.28.146.1
Necha1/scaffold_28:468415-469853
new family 49% to CYP5053A1,
44% to CYP5053A2
add to both ends
MLIFILPVVAAAVAIAYGVIWVLVDYVRILRLRRRMAPGPFPLPLFGNIFQIPNSRQWKKFEEWSFKYQSPIITIWD
GHTPVIICNDAWSMSNLCDKMANIYSSRVVKTLTGKIFGLNKFNQAGLAYGEQWRLHRRLTVSCGPYRYW
QGDTNPIISTRLQMPRL (2)
FVQGALRFTVSIVSVIAWGRRISSESDNVLKVAQAFVGSANLGFPGKTYTEAI
PILASMPPWLNALPNQLRKLADTSNKYFYALSVEGAEAAQDNFAKRLLREKEEHGLTKVEISNLTGNFIG
AGVDTTMSTMLTFVLAMCLNPYVQHKAQEEIDGVIGHDRYPDWSDEGNLPYLAAIINETLRWRPAFALGG
PPHAPTEDHVHNGFLIPKGTAVIGNLYAISRNPREYPXPQRFWPERFLDGFDRPAYPNKRGHNAFGWGRR
VCSGEALAQQSLYFTIVSLLWAFHIRPGLDEN (0)
EVTLDPDAYTVSQVNRPVPFKVRFLPRSEKIASLVKEGAENARSVLRAFDAETKVTFESA*
>CYP5053C1 Aspergillus oryzae
GenEMBL BAE64935.1, AP007171.1
45% to
CYP5053A1, 44% to 5053A2, 39% tp 5053B1
14
P450 genes and 2 pseudogenes on this contig
revised
3/24/2009 added N-term. Probable
gc boundary after HFQM
MIVERVEQLFALIQGQRILSHPGWSHVNFATLIPPVVVILGLALIVDYGYMIYLHFQM
(0)
PPGPFPLPMIGNTHLLPDQKPWIYFEQLAKEYNTP
MVTFWTGRRPTIWICDAWAADELLNKRAAIYASRPRMVVFSELGAGQSNMVN
MYYGDRWRLHRKLTHMGV
GLQQVRNYRGFQNDESKVVALDLLREPREYVSHFERYATSVVSIIGFGRRVSAYTDPIITEVVAVMQRAA
ELNVPGKSFPMLMESFP (1)
FLAKFPNWMAPWKHGLGNGQGRGRPFFYALAEEA
ASGPEAKQCYARKLFEEVPKHNLTKMEI
SSLAGNLFGAGSDTSSSTLVTFVLACCAFPETLPKAWEELDRVVGPHRSPTFEDESDLPYV
RAFVKEVLRWRSVAIIGGQPHAPIKDDRYK (0)
GWLIPRNTWVQGNVWAIHHHEREFPEPDRFNPERYFEESPVHRPFPVDKGYMTFGWGRRV
CSGQGLAEQGTFITIARLLWGFDIRKALDRHGNEVPVDIFDFT
NGLNMRPNSFECRITPCNQEIRSTIEREGLQALQDLSQYDGETKYRMSTYYNPEKL
>CYP5053C1 Aspergillus flavus
98% to CYP5053C1 Aspergillus oryzae
AFL2G_05205
One stop codon, possible pseudogene
Note: assembly error ASGPEAKQCYARKLFEEVPKHNLTKMEI
appears twice on either side of a seq gap
revised 3/24/2009 added N-term Probable gc
boundary after HFQM
MIVERVEQLFALIQGQRILSHPGWSHVNLATLIPPVVVILGLALIVDYGYMIYLHFQM
()
PPGPFPLPMIGNTHLLPDQKPWIYFEQLAKEYNTP
MITFWTGRRPTIWICDAWAADELLNKRAAIYASRPRMVVFSELGAG*SNMVN
MYYGDRWRLHRKLTHMGVGLQQVRNYRGFQNDESKVVALDLLRELREY
VNHFERYATSVVSIIGFGRRVCAYTDPIITEVIAVMQRAAELNVPGKSFPMLMESFP (1)
FLAKFPNWMAPWKHGLGNGQGRGRPFFYALAEEA
ASGPEAKQCYARKLFEEVPKHNLTKMEI
SSLAGNLFGAGSDTSSSTLVTFVLACCAFPETLPKAWEELDRVVGPHRSPTFEDESDLPYV
RAFVKEVLRWRSVAIIGGQPHAPIKDDRYK (0)
GWLIPRNTWVQGNVWAIHHHEREFPEPDRFNPERYFEESPVHRPFPVDKGYMTFGWGRRV
CSGQGLAEQGTFITIARLLWGFDIRKALDRHGNEVPVDIFDFT ()
NGLNMRPNSFECRITPCNQEIRSTIEREGLQALQDLSQYDGETKYRMSTYYNPEKL*
>CYP5053C1 Aspergillus terreus
82% to 5053C1 Aspergillus flavus
ATEG_01585.1
Check for missing region compared to CYP5053C2
MIIEKVEELIALIQPQPNFIHEQWSSMRLETAMLLVIATLGLLFITDYGYMIYLHFKMPPGPFPLPIIGNTHLLPESKPW
IYFEKLAKEYK AP MITFWTGRRPTVWICDAWVASELLDKRAAIYASRPRMVVFSELGAGQS
xxxxxxxxxx
NLVNMYYGDRWRLHRKLTH
MGVGLQQVRNYRGFQNDESKVVAFDLLREPKHYVKHFERYATSVVSIIGFGRRVATFSDPIITEVIAVMQRAAELNVPGK
SFPMLMESFPVLAKFPNWMAPWKHGLGKGQGRGRPFFYALAEEAANNPSSGQCYVKKIFQEAPKHNLSRMEISSLTGNLF
GAGSDTSSSTLVTFVLACCAFPETLPRAWEELDRVVGSHRSPAFQDEPDLPYVKAFVKEVLRWRSVAVIGGQPHAPIKDDHYK
(0)
GWFIPQGTWVQGNVWAIHHHEREFPDSDRFNPNRYMKDSPDHRPFPGEKGYMTFGWGRRVCSGQGLAEQGTFITVAR
LLWGFRIEKALDREGNEIPVDIFDYTNGLNMRPNPFECRITPRSAEIQATIEREGMQALQDLAQYDGETEYRMSTYYAMENL
>CYP5053C2 Mycosphaerella fijiensis
68% to CYP5053C1 Aspergillus terreus
e_gw1.14.529.1
MAVVESLSGHGWAAWILTSDVLLWTSVTLVPVAALLALLVDYVRILGLHRRMPPGVLPLPIIGNTHLLPENKPWIYFEAL
SKKLKSPVITFWIGRKPTVWINDAWSAAELLEKKAAVYASRPRMVVFAELTGMGQSSDADAKVPGTNLVTMYYGERWRVH
RKITHAGVGLQQVRKYRDFQNDESKLVAFSLVRTPHEYVAHFERYAASVVSIIGFGRRIASITDPLITEVIAVMQKAADL
NVPGKSFPMLFETFPWLANLPPQLFPWMFNGLGRRRRGQDFFYALADEARTKTPDEDCFVKTLFTEAPKYNLRKDEISSL
AGNLFGAGSDTSSSTLITFVLACCAFPEVLPKAWEELDRVVGHHRSPSWEDEAELVYVKAFVKEVFRWRSVAIIGGQPHA
PVQDDEWNGYKIPKGTWTQGNVWAIHHNENEFPEPDRFKPERFLKNDAASRPFPNEKGYMTFGWGRRVCSGQGLAEQGTF
ITVARLLWAFRIEKARDSHGHEIPVDIFNYTNGLNMRPQEFPCVFVPRSDDIRRAVEREGRQALENLSRYDGESERVGEF
FKKAKQNA*
>CYP5054A1
Nectria haematococca
fgenesh1_pg.scaffold_18000233
Necha1/scaffold_18:681283-683153
38% to CYP504E1, 38% to 504A1, 36% to 504A2,
only 30% to 504B2 in CYP64 clan
This gene model seems correct
MDLFTTLPGSPIALALLGLLALAALLLVCLNFFYVDFAKIKGIPEIPGGEVLAGHLYQLGHDHATTAATW
AAKYGWPVYQFRMGRRRVIMLNSFESAREWLVKNQSATIDRPWFYTFHGIVSKTS
(1)
AATIGTSPWDERTKKQRRVVGSFTTGPSIKKMNKMLDMETCAVISRIYYDSQNEADGISPHVYQKRLAL
NLMMMFCYGTRFNSVQDPMLLQILRDAKTIA (2)
SFRSTNSNPQDFIPHLRYVGKNRRMATATEVRERRDTWLAAMLKTVTTNLNRKRPGDKNCVAEMLLEDNQESLTE
(1)
LDIKTILGGLMSGGFETVYSTLIITIGMLSTEAGQMIQDKAYQDIMNAYD
SPQMAFEQCLLEEKSPYVVALVKEALRFYPPLKILPARQVYKTFTYEGATIPKGLLVYINTQAVNF
(1)
DKGTYGTDAGQFRPERWTDKANGIPPPYHFAFGAGARMCTAVNFSNRLLYAVFVRLILSFKMTPSKEMPPNTHP
IGYKEDPAASNAVASDFKIGFTLRNKEMVESFLRNSHEGLTNFVTGDNAEPLLL*
>CYP5054A2 Aspergillus niger
e_gw1.6.818.1|Aspni1
63% to CYP5054A1
MVALLDYYWPFNLVIVSVVAAGVLTIAILSYLRYLYVDFPSIQGIPEIPGGEILAGHLYQLGNDHATTAERWSLKFGWPV
FQIRMGHRRAVVINSFNAARDWMIKNQSATLDRPSFYTFHKVVSATSAATIGTSPWNERTKKQRRVVGSLTTGPAIQKLR
PMLDLETFSMVSGIYNDSENGRIGIVPHIYQKRLALNIMMMFCYGTRFESITDPLLLQILEDASTIASFRSTNSNPQDFI
PYLRYWRKEGRTATALEVRERRDKWLATMLDGARESIRLRTGDRKCVAKLLLTDEQEGLTKLDVKTILGGLMSGGFETVF
STAIIAIGVLSTPQGQYIQERAYADILNVYKSSEDAFELCVSEEKCAYISSIVKETLRFYPPLKLLPARQSFKEFMYQEA
VIPEGVLIYLNAQAANHQTVYGPDADEFRPDRWLKAEHDIPPPYHFAFGAGSRMCTAVKFSNRVLYATILRLIVSFRIVE
EEECPPNTHYVHYKRDPTASNAIASDFKVRFIPRDENALQRMFERSQELCAATIAETAGTVMGIP*
>CYP5055A1
Nectria haematococca
fgenesh1_pg.scaffold_187000002
new family add cyan at C-term, in CYP53 clan
MALLLQYFLALSGLICFYLGHSIIYNLFFHPFRKFPGPPLAKISRVWSRRANFQGLKYMRIHEAHQKY
(1)
GAVIRIGPNELSFADPLAIRDIYTTDDFQKEESFY (0)
FSKRGYEEDHLFSFT (2)
NPEAHSQRRKLLSRGYSQRSLLAIEQELSTKIQIFLQVIGKDSADGKPVDIYNRVHLLSFDVV
(1)
YWLLFGDDPKSLESGGEHKVLSYFRAWRPIFIY (0)
KEFWPQLEKIGIYLPGALGENFRKVKAWKE (0)
YSVDLIRKCRQNTVVTPFFRSVLYGEKDGYLDRPLTDSEVAEECMSGM
(2)
FGGTGTTANTFVFLLWATLQHPGVVEKLKAELRAAIPNVGSVPDYQ
(0)
AVINETLRLYPTIVAIIPRIAMRDTSVAGVHIQKG (0)
TIVGIQNYTIHRWEPAFPEPERFIPDRWLDDENIEQRKEAFVPFSVGSRRCIGIN
(2)
LAQMELSKLVAAFFRRYDATIDPSMQPEDMRMFDNFSAGPAGRKLLVRLNESTI*
>CYP5055A2 AAIM01002625.1 Gibberella moniliformis 7600
57% to CYP5055A1 runs off the end
AAIM01002626.1 Gibberella moniliformis 7600 = N-term exon
1
Missing exons 2 and 3
same contig as CYP628B1 about 16.5 kb apart
also Fusarium verticillioides FVEG_04314 revised
MLLDIHTSIFRIAV
322
LTLCALLVLKVAVSIIYNFFFHPLSKYPGPPLARISRLWSRIGNFQGRKSERIHEAHVRY 143
142 GSVVRVGPNKLSFSTPTAVQAIYTSNDFTKEESFY
(0) 38
RAKRIFHENHLFSFR (2)
DAEAHKTRRKNFSRGFSQSSMLDFEPHVSSKIKALLNQWATRANDGPIDVYPWCHWLGFDVI (1)
24778 YHLMFDEDPGSVPRGQPHQVMRYIKAWKPTYIY (0)
KEFLPQMEQYGVYVPGTIGGYFRDVRTWKK
(0)
YALKLIEEIRQKDSHTPFLRNVLSA 24419
24418
EKSGDAAQPLTNSELAEECMGGM (2)
24350
FGGSGTTANTFVYILWACLKQPNVVAKLRSELLQA 24178
24177
FPEPGLVPDYQ (0)
AVINETLRRYPTIVARSPRTAN 23998
23997
NDTVIDGIPVPKG (0)
TIVGTQNFTMHRNEDAFPSPEDFIPERWLA
23818
23817
ADGKETLKASWTPFSVGSRRCIGIN
(2) 23743
23692
LAQMELSKLTAAFFLRFDARVDEAMTEEDMRMYDTSNAGPAGARLFVHMREV* 23534
>CYP5055A3 Aspergillus niger
fgenesh1_pg.C_scaffold_2000945|Aspni1
56% to CYP5055A1
MLYLVLALSVPGYLIALTCYNLFFHPLRSFPGPPLAKVSKLWSRIGNRTGRKSDRIHEAHLKYGPVNPPPREPYIHRMHW
SDSMCASHVLIVPRDVQAHRQRRKFFARGYSQAAMLEFEPHISNKIDMVLKQWKARLVDGPIDVYPWLHWLAFDVVYHLM
FDDDPGQVTSGRSHEVMAYLQAWKPTYIYKEFFPQLDRWGVYVPGYVGDYFRKVQAWKNYSVNLIQRSRERGTKTPFLRS
ALNGDEDAFLGRPLTNSELAEECMGGMFAGSGTTANTFAFLLWACLRKPDVVARLKAELREAFPDPSIVPDHRTCSALPY
LQAVISEAFRRYPAAIAILPRTAVRDTTIAGVPISKGTVVGAQNRTVHFDEKAFPDAQDFRPERWLEKENEALRKEALAP
FSLGPRKCVGLNLAQMELNKLTAAFFRRFDGEVDGSMGEEDMRMYDTFTASPAGGRLLVRLRESV*
>CYP5056A1 Nectria haematococca
e_gw1.7.522.1
Necha1/scaffold_7:284482-286156
new family 34% to CYP665A1 AN2727.1 CYP64 clan
37% to gw1.271.3.1
MTTHSFLDELPHVHAIPLPESNPSSLPVLLAIVLVLVSALLLQAYLATRRPKNFPPGPPTTPFLGNILDV
PLSKPCVTFAKWAQSYGPILGIKAGPMNMVVLHDPDDIHELYDRRGSTYAGRPYNYIALNHVFEPDIGQI
YLFQRNDRLLKRWKRPARWFLSQQGIEGIVPILDAVGARCIKALCDSPSQFLEHLRVWAFSTPLIVLSGQ
THINKDLLRTYFYRQKLVTGLLEPGKTPPVDFIAPLRWLPTFFAKWKRDAYFVRKHQDAFYGEMLAGAVS
NRQRRKDGEKDVGEYEPVMARLLGEGMPEREVKWLAGGLLDAAFDTTSAAVANFVVALAGHAEVLKKARE
EVEAVCGGRMPTSEDVGKMPYLKACLME (0)
TFRWRPSAPLGLPHVTDADDTYKGYLIPRGTNIIVNAFAILH
NPDVHPNPTVFDPKRYLDPEKQTDEHSKSTWIFGAGRRRCVGDQYTMHALMAIMAKMVWALDMKVPEGTD
LSVEGGFDDGLMMKPRENVTVEFEVRDGRRERVEEEWQKGERMLERMLGKC*
>CYP5057A1
Nectria haematococca
fgenesh1_pg.scaffold_19000220
Necha1/scaffold_19:595776-597672
MLSVAKIATQLGQEATLYTVSALIIFALLSIAVLK (0)
CAYRLLLHPLRRVPGPFVARITDLYFFPSTFKCDRVY
(0)
VLRRLHEKYGPIVRVGPNEVSLSDWRMYRRIYTNKQALKDPKFYSPFSFLGHGNVFSVT
(2)
TSNAVDHSSRRKLQAKTYSQQEIASHASSILQRTDVLIDRLLKSASDSPTSTANAYDLFGAWGLEIICKLLVDADIPDD
PGQTIHMLEALEASPPTFFANILFPWLPTFRFKTSLPGILGHAYRAFDEWERLTIGMLKGYESQERDPGD
KKQFGVTPLLEANNKHLGRSYHFREALEEAMGIVLAGSGVSGHTFIYLIYALALPQGRRVQETLREELKG
VGDSLSELMALPYLSAVIKETYRVYPAIMSTLPRILGEPLEVADTDLTLPPGTVVGMQNYVHHRDPILFP
KPDEFIPERWLEGHKMSQGINLDDANAALTPYSVGSRNCMG
QTLAKTELYLSVPRLVRRLDFRLSSKMKP
DDMHMKDLWAVQPKGRRLFLDVKPVDG*
>CYP5057B1 Phaeosphaeria
nodorum
AAGI01000353.1 frameshift at 42065
40782
MATTLLHRDSLSHFGVVGLAFLLSVCYVTFF (0) 40874
40948
LVRRLLLSPIRTVPGPLRARLSQWPMIIQGLKGRRIY (0) 41058
41114
ELERLHRKYGSIVRIGPNEVSVADWRHMRAIYSNPKTVIKDPAFYDGVRMIGKHNIFQMTQVRPHLL (0) 41314
41355
HAARRKLSSPPYALSSITRLDPLIQKNADNLVNRLILGVSSSASGTVDAYELC 41513
41514
ALFSLETMCQAAFAKKFDKADGPEGSLELLRSLEGSALRFLPQSLFPFLGSTGLGIKLPG 41693
41694 FIGDAYRCHQIWEQQSRKMVDHFLEKSSADDKYLLSPVATGIDTFLDRRLSHEELIE 41864
41865
EAMGYMFAGSGTTSSTLTYLLYAISLPENLDIQERLREAVQKLPADDVTTIRQDPYVNAV 42044
42045
IKETFRL 42065
42067
FPTIVSTLPRLLLEPLQLDEYRLPAGTIVGMQNWMHHRDPVVFPNPDQFLPDRWLVPN 42240
42241
ASSHAMESSLTPFSIGRRNCIGQNLAWEELYIAVGAIMRAGLKLCLGPEMQPWEM 42405
42406
EIVDRFNIAPKGQRLMLHVTRD*
42474
>CYP5057B2 Gibberella moniliformis 7600
AAIM01002904.1
55% to CYP5057B1, 40% to CYP5057A1
also Fusarium verticillioides FVEG_12405
5687
MSGLFDNILGLSREALLAVLSVSLCLVYVSIK (0)
5540
IVGRLLFSPLRHVPGPSSTKLSGAAVWLSTIQGRRVY (0) 5430
5370
KLEELHKKYGPIVRTGPNEVSISDWRHLRTIYLNNKGMIKNPDFYEAATFVGKDNIFQMI (2) 5191
5102
NVQQHAARRKMSSPPYSLQSVALLDPLIKGNARRLAQRLKSGTSSPVDAYTFCGLF 4935
4934
SLEVICQAGFAKDFSNDTNGAAALKLLQAMDGSALTLLFDGALPFVARFDIGTKLPGAIG 4755
4754
DSYLKREYWRKKSYEMVDHFLEKSADDEKYLLTPLATGVDGYLGRKLTHEELVEEAM 4584
4583
GYMFAGSGTTSSTLTYLLYELSKPENAAIQERLRTEVLAISDDDIVAIRNNAYINAVI 4410
4409
KETLRAHPTIISTIHRLLTEPLTLGQYTLPSGTVIGMQTWLHHRDTSVFPDPEKFIPE 4236
4235
RWLNETPEMKSALTPFSLGKRNCIGQNLAWQELYWSVSEVMRSGSRFRVAEE 4080
4079
MKDWEMEMEDRFNIAPRGRRLMLTVSQVN*
3990
>CYP5057B2 Fusarium oxysporum (temp 5057B3)
91% to CYP5057B2 Gibberella moniliformis
FOXG_13126
MSGLFDNISDFSREALLTVLSLSLCLLYLSIK (1)
TIIRRLLFSPLRHVPGPSSTKLTGAAVWLSTIQGRRVY (0)
KLEELHRKYGPIVRTGPNEVSISNWRHLRTIYLNTKGMIKNPDFYEAATFVGKDNIFQMI
(2)
NVQQHAARRKMSSPPYS
MQSVVLLDPLIKGNAQRLAQRLRSGTSSPVDAYTLCGLFSLEVICQAGFAKDFSNDINGAAALKLLQAMDGSALTLLFDG
ALPFVARFDVGTKLPGAIGDSYRKRDYWREKSYEMVDHFLEKSTDDEKYLLTPLATGVDGYLGRKLTHEELVEEAMGYMF
AGSGTTSSTLTYLLYELSKPDNAAIQERLRTEVLAIPDDDIVVIRNNAYINAIIKETFRAHPTIISTLPRLLTEPMTLGQ
YTLPSGTVVGMQNWLHHHDASVFPDPERFIPERWLAETPEMKSALTPFSLGKRNCIGQNLAWQELYWAVS
EVMRSGLRFRVAEEMKDWEMEMEDRFNIAPRGRRLMLTVSPVD
>CYP5058A1 Nectria haematococca
fgenesh1_pg.scaffold_24000015
Necha1/scaffold_24:34924-36641
new family 31% to 543A1 , 30% to 502A1
This gene model seems correct
MLASYGQLVLISIVGAISIYAFRIASIKRRAKGAKAPPGPK (1)
GWPVVGNAPELASSDGNLIPIFNRWAKLY
GDIVQFSILGEKQILLSSDKIAHELFVKRGPKYSDRGTPHAMAYITRDLNPALMPKN
(1)
EAWRRERKLIHSA
ISITSNDKYLELMEEEAKLTMRDLVDYLSNFDNHMKRYAFGVLTRSMLGFRVSTAGDPFITETDSFIDEA
MKCFRPDEYPGNVFPFLRYLPTWLVPSLGNMERIKNKAYDEIFKLQKKVELSVRKGTASPSIYRHFFENR
DEYVISNEEAGYAFDSMIGGGTRSPYNALLTFLYLMMEFPEWQDKLQRHVDKVVGPDRLPCFADIPSLPM
VRAVVKEGIRYRSIMAELGIPHRLEEDDIYDGYFFPKDTVFHANYA
(2)
AILMDKDTYPDQQPFNPARWLEPL
YPTYKEPLTVHPNCQNFTPFGYGRRACPGYDFAERTLVILVAQIAWACEVKKPIDPETNKPVVIDMKYEP
TPNPRPLPFPCDIRPRSVDRSKLVKLEAARCEVA*
>CYP5058A2 XM_742056.1 Aspergillus fumigatus Af293 cytochrome P450 (Afu8g00560)
mRNA,
54% to CYP5058A1
Gene prediction has wrong N-term (first exon)
AAHF01000014 Aspergillus fumigatus
complement(join(661025..661409,661471..662275,
662337..662700,662860..662895))
locus_tag="Afu8g00560 fifth P450 of 8 on this
accession
MIISSYHLLWLALVAFILQYVAGIVSTRQRRQGAKVPPGPK (1) 83
139
GWPFLGSAPALAAVDTNGIIGIFKSWAEQYGSITQFSAMGDKQVILTEDKDARELFV 309
310
RRGIKYSDRGAPHAVEYISMKQNPGFRPKDDGWRRQRSMIQSAINITSINKYQSLMDDEA 489
490
TFTVNALLQSPDSFHGEFLRYSYSVLTSSLLGFSVRSPSDPFIHHNETFTAELMNSFRPD 669
670
CFPSNVFPVLRKLPMWLLPSLRTMERLRKEYVGEMWAFRRKIEKLVKEGSATECIYKHFL 849
850
LHRDQYNVTEEESVHTFQAMIDGGTRSPHNNLLTFLFLMMEFPEWQKKLQEEVDRVVGRD 1029
1030
RMPSYRDIPNLPTVRAIVKETVRYRSIVAEMGIGHCLQTDDIYKGYFFEKGTVFNAIFAS 1209
1210
ILMDKDTYPDGKLFNPARWLEPSYPTYKEPLTTYPNCQGFPAFGYGRRACPGVDFAERTL 1389
1390 VIMFAKLGWTMNIRWPRDEDGNELREELQYEPVPAPRPLKFGCRLEARDADRAKIVEE 1563
1564
AAKHLKLQ* 1590
>CYP5058A3 Aspergillus clavatus
91% to CYP5058A2
ACLA_004750 revised the N-term
AAKD03000007.1
1145440
MISLYHMSWLALVAFILQYVAGIWSSRQRRQGAKIPPGPK (1) 1145321 GWPVLGSAPALAAVDINGIIGIFKKWAEQYGSITQFSAMGDK
QVILTEEKDARELFVRRGIKYSDRGAPHAVEYISMKQNPGFRPKDDGWRRQRSMIQSAINITSINKYQRLMDDEATFTVN
ALLQSPDSFHEEFLRYSYSVLTSSLLGFSVHSPSDPFIHHNETFTAELMNSFRPDCFPSNVFPALRKLPTWLLPSLRTME
RLRKEYVGEMWAFRRKIEKLVKDGSATECIYKHFLLNRDQYSVTDEESVHTFQAMIDGGTRSPHNNLLTFIFLMMEFPEW
QKKLQDEVDKVVGKDRMPSYTDIPNLPTVRAIVKEAVRYRSIVAEMGIGHCLQTDDIYEGYFFEKGTVFNAIFASILMDK
NIYPDGKLFNPARWLEPGYPTYKEPLTTYPNCQRFPAFGYGRRACPGVEFAERTLVIMFAKLGWTLNIKWPTDKNGKELR
ENLQYEPVPAPRPLKFGCKLEARDTDRTKIVEKAAKHLSLQ*
>CYP5059A1 Nectria haematococca
fgenesh1_pg.scaffold_6000721
Necha1/scaffold_6:2168361-2170789
new family, add extension to exon 3
33% to CYP559C1, 31% to 559B1, 30% TO 559A1, in
CYP54 clan
MYSLWILAAAVIIWRLHTVFSHLSKVPKQVPWAYRSKFTPYLFSQLNGILNTPPAINRGYQK
(0)
YSKNGTLCAITLPFSRPEILIPRNLIRWATSQPDKILSPTPIQHEIVAAKYAFLNSSVGKDFAVYDVLRVQMNRYLPK
LIPQIMGELASQIDETFGLDTEWREVQVFLLVREVISRVTTRLVMGNTL
(1)
CNDKELVDNLSNFSSSVLPSAIAISLFPPFMHPFISRLTSIFNHIYMRRALKTLGPYVKQRIEAVRNDVAQ
GSKSLPREDVMTWHIEEALRKKEPR (0)
PEEGLEDRIACRAFATVFA
ALESTTLTMTHALFNLCATDDPEQTWEALAEEGRQAFAGEVNQASVNSLNRADSAVKETLRLHTAIKALS
VQVMASGGVSLDEHNLKLPQGSRVSVSAWGIHHDEDIYPNAYTFDAFRFSRPHENGMIAEDKKEAHLLVS
PSEDYLPFGFGRHACPGRYFAAVETKLFLAYMAVHYDLKQVHQRPGFVSLGHLPTPPIKGKLMIRRKRDI
CEPYKGDLPMA*
>CYP5059A2 Fusarium virguliforme
CG810696.1
FSAAN78TR genomic survey sequence
70% to CYP5059A1, first two exons only
696
MYSIWIFLAAVVVWRLYTAYGHLSKVPKGVPWADTSKFTPYLFSQMNNIRNTAAAIDEGYQK (0) 511
461
YSKNGTLCALALPFSRPEILIPQKLIQWATTQPNKVLSPTPVQHEVIAVDYTFLDSSVGK 282
281
GNVAYDILRIQLNRHLPKLIPEIMQELAGQIDETFGFDTEWKEVQAFLLVREVMAKATAR 102
101 LILGDTL
(1) 81
>CYP5059A3 Neosartorya fischeri NRRL 181
AAKE02006477.1 55% to fgenesh1_pg.scaffold_6000721
AAKE02001791.1 Neosartorya fischeri NRRL 181 65% to
fgenesh1_pg.scaffold_6000721
about 60% to CYP5059A1 Middle region not in database
627
MFPLIILMLGAVAWRMYTSIKHLSTIPKEVPWVGRTGTFSTYLSSQIQAIRNTPSAINEAYNK (0) 815
862
YNKNGAICAIPLPFSRPEILVPRSFVRWMLSQGDAILSPLPVQNEIVGPKYVFLNPSVHG 1041
1042
DYAVYNVLRAKLNRQLPMLIPAIMEELAARVDQFWGMDTDWREVQSHPLVRNVVGRVSGR 1221
1222 IILGSPL
(1)
2
ALKETLRLRTSIKALAMQVTAPSGITLDGGKLRLPQGSRLSVSSWGIHHDEEIYPSASTF 181
182
DAFRFSRPREGGETADANAATNGNDNKHLMVSASETYLPFGMGRHSCPGRYFAAIELKLL 361
362
LAYLAVNYDIKLAGERPAFVSIGHFPIPPLNGKLMIRRKRGTAVGMDDPTGV* 520
>CYP5059A4P Gibberella zeae PH-1
AACM01000113.1 strain PH-1; NRRL 31084 chromosome 1
note new Pseudogene not in Fusarium graminearum collection
2807
EIDKNLSQCSLAIMPSAIGIDIFPPFMQPIAAHLTCFLYDSLLDVRTEDLGCPIHVDAIE 2628
2627
IDNEISKTQPQNDIMTWHIKEALRKKESR
2541
2512
IASRIFATTMAALEAVTLAVAHALFCVGSSNSSAQIWRALEEEARHILHRPINQDSVD*L 2333
2332
HFADAAIKEHLRLQTAIKALTVQVMHPTGITIKDIGVYQRQGAHISVLA*GIHHDEYIYP 2153
2152
NAYTYDTFRFAPQRRNACNSEGSDDEYLMTTPSEKYLSFGFGKHVCPGRQFA 1997
>CYP5060A1 Nectria haematococca
fgenesh1_pg.scaffold_24000138
Necha1/scaffold_24:351790-353582
29% to 609A1 Magnaporthe, micro exon 11 bp at
heme region
This gene model seems correct
MAILLNSLAALQFKAGSFIAVIVILIALVAVAPLLGRLAPPRGAPRAFGGHGGLNSPTFTKSRNEYLRHG
KEQSPDKQFSFWHGPNHMVSVSGDVARTVFLTSRKLNALAA (2)
FATLSGSFLKIDSLTNSYVRLALLTFKRC
AQDEHIEVNLPRLIDDSRRFLETIDQSEAWDPVENLSYLMYQLTHRMAGTHDIANDPDLVARTRDIYKPL
DDYSLFEIWFPLLPTPSKFKKAWAYARLHWIVQGFITDRRRTGRRESDAMQMMMDQEFTDPVITV (0)
AVIGAMLAGVLNMTVNGAWNLLYLAHNPNWLSKLRTEVDQAIVKYRRSANEDVSDVFKRLGLKDWESEFPLFEQI
LKETMRFTMAGQIVRKNIGNKGVSVGDTDFVIPKDSLA (0)
VYSVEDAHMDPSVYRDPLEWDPSRYDKGKDEGLQSPHSFLGWGSGNHRC (1)
PAMR (0)
FSKLNMLVPTVMLVALYDFEVCNDQGESSNEPLPSLSYDGVGSGRPTGKVHVKFSPRTREGV*
>CYP5061A1P
Nectria haematococca
gw1.14.57.1
Necha1/scaffold_14:171902-173237
38% to 68A1 missing N-term, two stop codons,
possible pseudogene
39% to 68D1, 39% to 68L1
42% to
gray box matches CYP68L1 Aspergillus nidulans
cannot find N-terminal with any confidence,
first exon may be missing
MMHWNPASEKSTSPSPGFKRCLLVLDFSLNFGNLTFTSNFDLLINMPEITENTPPSLLAQLSVLALQ
PYASLSG (0)
HGDSFQVYTPTGPMIVLSRKYTNEIRNHKLLSFQQNINK (0)
ASFTSLPGVGLMPGMAGFLFDVHSSEVFKGVVRTQLTQSL (1)
GRITAALSSETAAALEEYFPPRN (1)
DWQECVFYPTTVDLVFRL
SARVFLGEGICRNKGWLKVSGAYAVEGIEFTRVLRFWKPIVRPIVQFFLSERLQMMKSERVARRIINEEL
ERRCLEQTEGARAGRPVRKYDDALQWLQDWR*KSGEKFDIVGGQLGLGIGAIHTTSMALSRVLYDLIDNP
EWVQPMRDEVKRVLEEDGEWKKTTLHKLKLMDSVLKESQRRNPVHL (1)
TIMTRIAEGNVTFSDGLKVRKGDM
LTVTTPEVMMDSELFPELERFIGDRFLKLR*ILGNENKWQYVATSTEHIGFGHGEHSCPGRFFAGNELKV
ALAHMLLKYDWKFAEGCDSRNVEMAQDVIPNPIAKVLFKERQPEIDL*
>CYP5061B1 Aspergillus terreus NIH2624
AAJN01000160.1 cont1.160, whole genome shotgun sequence
ATEG_05844.1
16164
MTVILDVLDTHHLVQ
GIAVALLLVFVSSFYGDLADGIPYRNIPLVGRSRWEISNKKAKQRFVSSAKELMAQGFSQ (0)
GRTVFQLMFAQSATIVLHPKYVNEIKNNPSLNFDEANKK (0?)
SFFGSKIPGFEPFDGIDKEGILLEVINKKLTHTL (1)
GQLTIPLSRETATVLSEKLPKSG
(1)
16898
EWQSFTFAQEIPHIVARLSSLVFLGQKICRNQEWLNVSVNYTIDAFLAARDLRLWPSVTR 17077
17078
RIVHWFLPSAKRLRHHTVVATEIIQAEIQKRELIRTGKLPEEDPPRTHADALDWFAEVA 17254
17255
AGRPFNVIRSQIGLSLAAIHTTSNLLTNIMYDLTAYPEHIQPLRDEIKAIVDEDGMLKK 17431
17432 TSLTKMKRMDSVMKETQRLNGAGI (1) 17491
17569
AFLNRIAMDEVILSDGTRIPKGASITVSAHHMRDESIYPDAQTYRGFRFYDKRQEAGN 17742
17743
EHRFQFVTTSPEHLGFGHGIHACPGRFFAANEVKILLAHLLLKYDWKFAEDVGAGRPPNI 17922
17923 MHGVENICNPTIKLLYKARQPEVDLAALGEGAE*
18024
>CYP5061B2 Aspergillus fumigatus A1163
ABDB01000053.1
Aspergillus fumigatus Af293
Also
on GenEMBL XP_750704.1 from genomic seq AAHF01000006.1 chr 6
42% to
68L2,
91% to
CYP5061B2
Neosartorya fischeri = ortholog
Note:
CYP5061B4 was part of this sequence and the two are now combined
552705
MALIFELLQSPYFLQGIAVSLLLVIVSNFYQELVDGFPYRNIPLVGMSRWGFANSKAKER 552526
552525
FVASAKALIAQGFSQ 552481 ()
552428
GRTAFQVMFSHAPMIVLHPRYMDEVKSHPHLTFDEANRK
AFFGAKLPGFEPFGLDKITVDVINNKLTHAL
GSLTTSLSRESAAVLKESLPPKSD
EWQSLVFAQEIPYIVARLSSLVFMGEKVCRDKEWLHV 551889
551888
SVNYTIDAFGAARELRLWPSVTQPLVHWFLPSTRRVRKHISVAKKIVQKEIEKRELIRQG 551709
551708
KLLEYSPPKPNDALDWFREVAAGRPYDITKSQITLSLAAIHTTSNLLTNIMYDLIAYQEY 551529
551528
IQPLRDEIVAVVKEEGCLKKTSLTKLKLMDSFIKETQRLNPVSI
551341
ASLQRYALADITLSDGTFIPKGAMLIMSAHTMKDESIYPHADTFDGYRFYNKRKEPGNEH 551162
551161
RYQLVTTSNEHLGFGHGLHACPGRFFAANEVKILLIHLLLKYDWKFAEDRGRPQSIMYGT 550982
550981
EIICDPTVKLLYKARTPEIDPSKLGELSTDSPSV* 550877
>CYP5061B2 Neosartorya fischeri NRRL 181
AAKE02000017.1, NFIA_053810
70% to CYP5061B1
Supercontig 582: 2020434-2022262 (-) strand
530186
MALISELLQSPYFLQGIAVSLLLVVVSNFYRKLVDGFPYRNIPLVGRSRWEITNSKAKER 530007
530006
FVASAKALFAQGFSQ (0)
GKTVFQMMFSHSPMIVLHPRYMDEIKSHPHLTFDEANRK (0?) 529794
529750
AFFGAKLPGFEPFGLDKEGIALDVINKKLTHTL (1)
GSLTISLSRESAAVLKETLPPKSD
(1)
EWQSLVFAQEIPYIVARLSSLVFMGEK
529394
529393
VCRDKEWLHVSVNYTIDAFGAARDLRLWPSITQSLVHWFLPSTRRVRKHISVAKKIVQKE 529214
529213 IEKRELIRQGKLLEYSPLKPDDALDWFREVAAGRPYDMTKSQISLSLAAIHTTSNLLTN 529037
529036
VMYDLIAYQEYIQPLRDEIVAVVKEEGCLKKTSLTKLKLMDSFMKETQRLNPVSI (1) 528872
528819
ASLQRYALADITLSDGTFIPKGAMLVISAHTMNDESIYPHADTFDGYRFYNKRKVPGNEH 528640
528639
RYQFVTTSNEHFAFGHGLHACPGRFFAANEVKILLIHLLMKYDWKFAEDRGRPQSLMH 528466
528465
GTEIICDPNVKLLYKARTPEIDLSKLGELPTDSPSV* 528355
>CYP5061B2 Aspergillus flavus
100% to CYP5061B2 Neosartorya fischeri
no oryzae ortholog is found
AFL2G_12481
N-term in a seq gap and C-term is in a seq gap
SHSPMIVLHPRYMDEIKSHPHLTFDEANRK (0)
AFFGAKLPGFEPFGLDKEGIALDVINKKLTHTLGSLTISLSRESAAVLKETLPPKSDEWQSLVFAQEIPYIVARLSSLVF
MGEKVCRDKEWLHVSVNYTIDAFGAARDLRLWPSITQSLVHWFLPSTRRVRKHISVAKKIVQKEIEKRELIRQGKLLEYS
PLKPDDALDWFREVAAGRPYDMTKSQISLSLAAIHTTSNLLTNVMYDLIAYQEYIQPLRDEIVAVVKEEGCLKKTSLTKL
KLMDSFMKETQRLNPVSIASLQRYALADITLSDGTFIPKGAMLVISAHTMNDESIYPHADTFDGYRFYNKRKVPGNEHRY
QFVTTSNEHFAFGHGLHACPGRFFAANEVKILLIHLLMKYDWKFAEDRGRPQSLMHGTEIICDPNVK
>CYP5061B3 Aspergillus clavatus NRRL 1
AAKD02000005.1 ctg02_1099423829616, whole genome
78% to CYP5061B2, 73% to CYP5061B1, 44% to CYP5061A1P
ACLA_082520
591865
MALISELLESRYLLQGIALAFFLVIVSHFYQELADGYPYRNIPLVGRSRWELSNGKAKDR 592044
592045
FVKSAKELMAQGFSQ (0)
592170
GRTVFQLMFTHTPMIVLHPKFIDEIKSHPHLNFDEANKK (0)
592344
AFFGSKIPGFEPFEGLDKDHILLDVINKKLTHTL (1) 592445
592496
GNLTIPLSQETAAVVKETMPPRTD (1)
EWQPLMFAREIPYLVAR 592675
592676
LSSLVFLGEKICRDKEWLNVSVNYTTDAFIGARALRLWPTITRPVVHWFLPSTRRVRKHI 592855
592856
RVAKKIVQDEIQKRELIRQGKLPAEDPPRTHADALDWFREVAAGRPFDETRNQIGLSLAA 593035
593036
IHTTSNLLTNVMYDLVAYQEYIQPLRDEIRAVMEEDGSLRKTSLTKLKLMDSVMKESQRM 593215
593216 NPVSI
(1)
AFLQRLAKADLTLSDGTYIPKGATLIVSAHAMRDE 593395
593396
SIYPDANQYDGYRFYNKRQEPGNEHRFQFVTTSPEHFGFGHGIHACPGRFFASNEVKILL 593575
593576
IHLLMKYDWKFAEDKGRPQGFMHGTEIICDPRVKFLYKARTPEIDLSSLGEGLAA* 593743
>CYP5061B5 Aspergillus oryzae
GenEMBL BAE57341.1
73% to
5061B1, 45% to 68D1, 41% to 68L1
68% to
5061B4
MPVLATFLESHYFFQGIAVALALIFVSNFYRELADGLPYRKIPLVGRSRWEISNTKAKKLFVTSAKDLMV
QGFSQGRTVFQAMFTAGPTIVLHPRYVDELKNHPHLDFGEAVRKSFFGATIPGFEPFNNQTKEDIVIEVI
NKKLTHTL GQLTIPLSKETAAVLTDKLPGSDEWKPFTFAQEIPHMVARLSSLVFLGEKICRNETWLDVSV
NYTIDAFNAARELRDLPAVARPFIHWFMPSMQKLRHHRKVAAEIVQQEIIKRDMIREGKLPEENPPRTHA
DALDWFREVAAGRPCDETVSQIGLSVAAIHTTSNMLTNVMYDLTAHPEYIQPLRDEIKAIVEQDGILKKT
SLTKMKLMDSVMKESQRTNPVSIAFFNRIATEAVVLSDGTSIPKGANVVVSAHVMEDESIYPNAKVYDGF
RFYNKRQVPGNEHRYQFVTTSPEHLGFGHGMHACPGRFFANNEIKILLAHLLLKYDWKFADRVDRPKSFL
HGTEIICDPTVKLLYKSRQPEVDLSALGEGTTD
>CYP5061B5 Aspergillus flavus
99% to CYP5061B5 Aspergillus oryzae
AFL2G_02841
MPVLATFLESHYFFQGIAVALALIFVSNFYRELADGLPYRKIPLVGRSRWEISNTKAKKLFVTSAKDLMVQGFSQGRTVF
QAMFTAGPTIVLHPRYVDELKNHPHLDFGEAVRKSFFGATIPGFEPFNNQTKEDIVIEVINKKLTHTL
(1)
GQLTIPLSKETAAVLTDKLPGSDEWKPFTFAQEIPHMVARLSSLVFLGEKICRNETWLDVSVNYTIDAFNA
ARELRDLPAVARPFIHWFMPSMQKLRHHRKVAAEIVQQEIIKRDMIREGKLPEENPPRTHADALDWFREVAAGRPCDETV
SQIGLSVAAIHTTSNMLTNVMYDLTAHPEYIQPLRDEIKAIVEQDGILKKTSLTKMKLMDSVMKESQRTNPVSIAFFNRI
ATEAVVLSDGTSIPRGANVVVSAHVMEDESIYPNAKVYDGFRFYNKRQVPGNEHRYQFVTTSPEHLGFGHGMHACPGRFF
ANNEIKILLAHLLLKYDWKFADRVDRPKSFLHGTEIICDPTVKLLYKSRQPEVDLSALGEGTTD*
>CYP5061B6 Aspergillus niger
fgenesh1_pg.C_scaffold_4000153|Aspni1
73% to CYP5061B1
MAVILEVLDNQHLLQGVVLALVLVFVSSFYHEIADSFPYKNIPLVGKGKWEITNTKAKHRFVTSAKELFAEGFSQGRKAF
QVHFSARPTIVLHPSLTNEVKNNPLLDFNEANKKSFFGSKIPGFEPFDGLDHEGIFLEVINKKITQGLGQLTTPLSRETI
AVLNEKLPDSGEWLPFTFAQEIPHIVARLSSLVFLGEKICRDKQWLDVSVNYTIHAFVAARDLRLYPTVLRPFVHWFLSS
TRRTRQDIRVASAIINREVEKRKLIREGKLPEEDPPRTHADTLDWFEEVAAGRPLDLAVAQVGLSLAAIYTTSNLLTNIM
YDLTAYPEHIQPLRDEIKAIISEDGGLKKTSLTKMKMMDSVLKESQRMHPAGVAFINRVAMGDITLSDGTRIPKGASIAV
SAHNMEDESLYPNAKTYDGFRFYKKRQEPGNEHRFQFVTTSPEHLGFGHGMHACPGRFFASNEVKILLIHFLMRYDWKFA
DGRTTRPMNFMHGTESICDPTVEFLFKPRQPEVDLS*
>CYP5061B7 Aspergillus niger
fgenesh1_pg.C_scaffold_15000297|Aspni1
52% to CYP5061B3
MSRWFLFDRHANVCFMASARALIREGFEQVVPSWTYLSFGLIRWDTARIGPHDVPSNVSPRPYYVDEVRRHPSLSLEEAV
KESLPVGDYPGFEAFRGTENHHILLDVINQKITRNLKQYTIPLARETELTLDEHFGQPQEWKSYCFASEVPYIVARLSTL
VFLGEQVCRDTEWLDISVNYTLDIFGAITALRGWPPILRPVVHWFLEPAQKLRKRVQVARRIVQREMRRRQHEHKPRQPD
ALDWLHEVAGGRHLDVTTAQIGLTLVTIHTTSNLLTNVIYDLAANPQYLPPLREEIQSVLETDGTFHKTSLTKMKLLDSV
VKESQRLNPPGLTSLHRYAMEEITLSDATVIPKGASLVVSAHTMQDESIYLNAHTYDGYRFYRKRQEPGHENKHQLVMTS
AEHYGFGHGVRACPGRFFATNEIKILLAHIILKYDIRFPDGQSRPANWEIGQDLVCDQTVQVLFRAR*
>CYP5062A1 Nectria haematococca
fgenesh1_pg.scaffold_7000468
Necha1/scaffold_7:1339234-1341197
new family add exon 3
NLLRVFTSPLSKIPNAGFGAAYSRLAWAFPREYKGTVTIDLPKLHEKL (1)
GPLVRIGPNEVSFYSRETYETVHKVGSKFRKDPRVYGEFVQGGHPALFSIT (2)
DPEQHAKRRRIMGQLFSRTKVPQLEKLISSHVDRFVQLIRENGPNVDLAVASRALEADIM (1)
STFSFGKSIEAVDSWASGKELEMVAKNDLKATWMPV (0)
LTNFPLLCELLEQLEGAIFRVTGVRSAYTKGLTEFQQ (0)
WCRDSWKLAISEDSELDEPATKSPNLIKSLCNSGLHAETALSEAKENLGPGTDTTSATLAHILWALAQNPDYQNALYED
LAAVSFYTDMTTLESVPRLQACVKEGIRWAGAAAAMLPRIVPPGGIELHGKFIPEGVREQ (0)
TVLTSSPIWYQHDKTAFPNPKVYNPYRWLTDDCKGMSEDKLRDRFYIPFSRGANICMGAH (2)
FAYLELYISVSQVIRNFHLEICNITQRSTLEKNEETNWTPVPLPKRREWVAAVPMEKLEVKMCPRL*
>CYP5062A2 Botryotinia fuckeliana B05.10
AAID01003245.1 cont1.3245, whole genome shotgun
59% to CYP5062A1, GC boundary at intron 7 after VRIL
MPLPLSLLAECTAFVLVGLCLI (0)
10810
RIAREYFSPLSSIPNAGVCAPYSRLLWAFPTEFRGRITLDLPKLHQKL (1)
10614
GPLVRIGPNEVSFYSMEMYDAVHKVNSRFKKDPRVYGEFVQGGSPALFSIT (2)
10447
DPVEHSKRRRLMGQLFNRSQMHKLEGLMLHHIEGFVQNIASSRDGVDLL 10268
10267
PVCRALEADIM (1)
SDFSFGHTIGALDAYFQGAELDMIAKNDQKATWMPL
(0)
LTSFPGLCNTCERTEQIVSSITGYRTPYSKAMLDFHQ (0) 9908
WAERSWRTALSNNASQEKSTSPFPNLVQTMVNSNLPSSTA 9733
9732
LSEATENLGPGTDTTSATLAHILWALGSNPGFQEDLFQDLVTVSFATDMTTLEGIPRLRA 9553
9552
CVKEGIRWTSAATAMLPRLAPEGGAEFYGHFLPENVRIL (0) 9436
9377
TVISSSPVWYLHDPVAFPRPKDFDPYRWLTSDGQNIRDDPLRDKFYIPFSKGANI 9213
9212
CMGAH (2)
FAYLELFLSISQVIRNFRVQTHPWSQPRSYPDEAKGSSPGVFQPVELPNRREWVAAVPTERLMVALEPRL*
8922
>CYP5063A1 Nectria haematococca
e_gw1.8.270.1
Necha1/scaffold_8:576949-578514
35% to 663A1 Aspergillus nidulans, no introns
This gene model seems correct
MIDSTLIVVLLLTIITAVYLYLKSDDEGPGPRKFPLFGDLHYSPVEKPLINWDAWAKQNGAIVAARLFGI
VPIIILNTSEVATELFSKRSQWYSNRPRSVTMEMITGAGPGKCKFTLLHDYDADLQQYHRILSPTIGAPS
APRYQPLMELESMQLLVDLVALAERDKDHITSTRIVYPHFERTQGSIIMSLHYGMRIPTCEDPILHQVVK
IQAKLSHLVAHPGLPDSLPALRHLPALVSPWKRHANKIYDEQTKLYMKLMNHGRRFEGWNATKKIIAATE
KQTQSPQLPHLDLAFMLATSIQGGMETSPRQILWLFPGLIKNPGFLKKAHAVLDEVVGHDRLPSFQDRPK
LPLIDAAVHELLRWRPVAPGSVPRRADRDDHYKGIKIAKGNMVMANAWGIGRDDAVFDPSLGNLDDYVPE
RWLMHDENNGQPKLRSNLPLAAFGQGRRSCLGKKVAIDGMFIQVARLLWAFDIEPVEEVDPWKMDVVGLM
IIPNNFRFKLKPRSILAGATIKKEWNKADQL*
>CYP5063A2 Aspergillus fumigatus
BX649605.1 BAC pilot project supercontig; segment
56% to CYP5063A1
44210
MAATSVVAVIVIGLLTVLYISRKNGKKTDKVLLKLPLIGDLHSSPIEKPLANWDSWAQQN 44389
44390
GPIAVPKLFGIIPIVVLNSYEAATELFNRRSQWYSNRPPSVSMEMITGAPPGRSRFTLMH 44569
44570
DYDDHLKLHHRILSPSLGALAAPKYQPLMELEAKQLLHDLVKALQHSPDGATISTNTIYP 44749
44750
LLERTQSSVILALHYGLRIPHPDERILHQVIDIQVQVTHLAANPALPDLIPALRHLPAIL 44929
44930
SPWKRAADRLYAAQVDLYMRLFHHGRDAAGWNATKQALSTAAKYAPASSSSSSSSSSSSS 45109
45110
SSQIPDLDLAFTLATSIQGGMETSPRQLLWLFIAALHQPSFVTRAHAVLDEVVGRDRLPR 45289
45290
FSDRAQLAFIDAVAHELFRWRPIAPGSIPRRADRDDEFQGVKINKGVTIMANAWGIGRDE 45469
45470
QVFDPALGDLQEFVPERWLRAGEAGEERLRSDLPLPVFGQGRRICQGRRVAVDGTFLQV 45646
45647
ASLLWAFDVAMVDDGAGPVDPWEMVVVGFMTMPKERRFKLKPRGDWVLDVIKREWETAEK 45826
45827
SLDKVMGTNDVE* 45865
>CYP5063A2 Neosartorya fischeri
93% to CYP5063A2 Aspergillus fumigatus
= ortholog
NFIA_014190
MAATSVVVVIVIGLLTVLYISRKNGKKADKLLKLPLIGDLHSSPIEKPLANWASWAKQNG
PIAVPKLFGIIPIVVLNSYEAATELFSRRSQWYSNRPPSVSMEMITGAPPGQSRFTLMHD
YDDHLKLHHRILSPSLGALAAPKYQPLMELEAKQLLHDLVNALQHCPDGTTISTDAIYPL
LERTQSSVILALHYGLRIPHPDEHILHEVIDIQVQVTHLAANPALPDLIPPLRHLPAILS
PWKRAADRLYAAQVDLYMRLFHHGRDAAGWNATKQALSTAAKYAPASSPSSQVPVPVPVP
DLDLAFTLATSIQGGMETSPRQLLWLFIAALHQPSFVARAHALLDEVVGRDRLPRFSDRA
RLAFIDAVAHELFRWRPIAPGSIPRRADRDDEFQGVKINKGVTIMANAWGIGRDEQVFDP
ALGDLQEFVPQRWLREGEAGEERLRSDLPLPVFGQGRRICQGRRVAIDGTFMQVASLLWA
FDVEMVDGAGPVDPWEMVVVGFMTMPRERRFKLKPRGDWVLDVIKREWETAEKSLDKVMGTNDVE*
>CYP5063A3 Aspergillus niger
e_gw1.8.180.1|Aspni1
70% to CYP5063A2
MIANLAIVVVFSIGVITLLYVITSHQPNRRAATDEKRPPLKLPLIGDLHSSPIDKPLANWDDWARQNGPITVSKLFGIVP
IVVLNSYEAATELFSRRSQWYSNRPRSATMEMITGAKPGQSRFTLMHDYDDYLRLHHRLLAPSLGALAAPRYQPLMELEN
NQLLCDLCDALHGCPDGATISTATIYPLLERTQSSIILGLHYGLRILHPEDDLLQEIIGTQAQVTHLAANPGLPDLIPTL
RQLPGFLSPWKRAADELFATQSNLYMRLFHRGRDSDSWNATKQALATAERYTAVPDLDLAFTLATSIQGGMETSPRQMLW
LFIAMLHRPSVLSRAHAVLDAVVGRSRAPRFSDRPKLVYIDAIAHELFRWRPISPGSIPRRADRDDEFQGVKISQGVTIM
ANAWAVGRDAQIFNSALGDLPDFVPDRWLLQGNPHNAEAQLRSDLPLPVFGQGRRICQGKRIATDGAFLQVANLLWAFDI
MSAEGEEMDPWAMTVVGFMTMPKELKMRLKPRGDWVMEAIKREPKIGSEDLDQVMGSVNDVE
>CYP5063A4 Fusarium verticillioides
55% to CYP5063A3 Aspergillus niger
FVEG_13079 no introns, not found in the F.
oxysporum genome
MAVSSISVLVLGIVAGAALFYLWSPTGKYRKRPLKLPIIGDIHSSPIERPL
LRWDDWVKENGAIATSKLFGIVPVVVINTAEAATELLGRRGAWYSNRPR
SVGMEMITGAGPGKSRFTLMHDMDAHLKLHHRILSPSLGGIAAPHYQPVM
ELEAKQLVKHLVEISEQKSLVIASDDIFPLLERAQAIIILALHYGVRVPT
LDDPLYKRVRETQAKVTSYASKPGLPDIFPFLANLPAIISPWRKAADELF
NKQKDLNLHLLSLGDDNPGWNATKQSRSLAAKYTKEPISDTDLAFTLATS
VQGGIETSTRTILWLFIAATTGNKRFMKRAHDLLDAVVGRDRFPRFSDRS
SLCYIDAIISELLRWRPISPGGVPRRADKQDYFNGIRIVKNAMVLTNAWS
IGRDEAVFDQSLGGLDEFIPERWVDGESMDTDIKNQGELRTSLPLPVFGH
GRRSCLGKRVAVDGTFAQVATMIWAFDFERAEEVHEMEMKVVWFMTEPKP
FKFKLKPRGPWVLKVIEEEWRTADKELSNIMGNISDIES*
>CYP5063A5 Aspergillus clavatus
76% to CYP5063A2
ACLA_004470
MTATVLAFLAAGLLSLLCIHVHARKDSKQIKLPLIGDLHRSPIEKPLVNWDSWARENGPIAVPRLFGLIPIVVLNSYEAV
TELFSRRSQWYSNRPPSVSMEMITGAGPGQCRFTLMHDYDEHLKLHHRILSPSLGAPAAPRYQPVMELESNQLLLDLVNL
LRKSADGTTDTTSTDAVYPLLERTQSSVILALHYGMRIPNGKEKVLHEIIEIQTQITHLAANPRLPDLMPALRHLPAILS
PWKRVADRLFAAQTDLNMRLFRHGRDAAGWNATKQAISAAKKYTSSASPPIPDLDLAFTLATSIQGGMETSPRQLLWLFI
AALHSPSFVARAHTLFDEVVGRDRLPRFADRAQLAFIDAIAHELFRWRPIAPGSIPRRADRDDEFQGVRIAKGVTLMANA
WAIGRDDKVFDPALGDLQDFVPDRWLRQTDADNEGVQLRTDLPLPVFGQGRRICQGRRVAIDGTFMQVASLLWAFDIEPV
DGTEAVDPWAMMVVGFMTTPPDVPFKLKPRGDWVLKVIQREWKTVEKDLDKVMGAAIDLEK*
>CYP5063A6 Aspergillus terreus
79% to CYP5063A2
ATEG_07362.1
MVIAPYVVVLAVGLVTWLYMSTRKKNVNTVVDGNKPLLKLPLIGDLHSSPIDRPLVNWDAWTKQNGPIAVPKLFGIVPIV
VLNSFEAVTELFSRRSQWYSNRPASVSMEMITGAEPGRSRFTLMHDYDEHLKLHHRILSPSLGAVASPQYQPLMELESKQ
LLFDLANALQKCPDGATISTDAIYPLLERTQSSVILALHYGLRIPRFEEPILHEIIDTQTQVTHIAANPALPDLIPPLRH
LPAFLSPWKRAADKLYAVQVDLYMRLFHHGRNSPGWNATKQAICTAEKYAPVDSP
VSDLDLAFTLATSIQGGMETSPRQL
LWLFIAALHQPSIVTQAHAVLDAVVGRDRLPRFSDRAQLTFIDAIMHELLRWRPISPGSIPRRADHNDEFGGVKINKGVT
VMANAWAIGRDQAVFDPALGDPQEFIPERWLRHDANGDTKLRTDLPLPVFGQGRRICQGKRVATDGTFMQVASLLWAFDI
QLAEGQPVDPWEMVVVGFMTMPRERKFKLIPRGDWVLDVIRREWNDAEKSLDKVMGMAYDVEG*
>CYP5064A1 Nectria haematococca
fgenesh1_pg.scaffold_14000017
Necha1/scaffold_14:53762-55160
new family top half of gene 48% to AP007159.1
Aspergillus oryzae
There is a sequence gap after IIKAW added seq
from e_gw1.15.528.1 (Necha2)
49% to CYP5064A2
MGFRYVLSIVAAEACAHYKSLALSFASILAVYCLSAFLFNLFWHPLAKFPGPKLAAWSQWWLSYHEAIKG
ESLIDILRTLHATY (1)
GPVVRYGPNL (0)
LHFSTFQAHCDIYNQNSRWDKDKMVYAAVMEENSSFGMTSHKAAKQRREVVQPFYSRRNILKMQEAIDRQ
(0)
MQILVARLTQDGEGGCLSDLSLAFRCLAQDVMTEICLGISSKTLNA
PGYESPLILAMDENLRSFVPMKTFPTFRRLMYSLPPSLTPGEEVLTEYETMVENHVNKAIEDPCSFDGIS
PVTMLPYLVNRSDKNKLDTESLIGELQAFIVGGGETVASAMVLGIHGILRHPNLYPRIQAEIIKAW
PEVSGPVPGLEVLEKLPLLTATIKESLRLTHGVVSPLPRIVPEGGAQVDGHFV
PGGTSVGVSHVFVHLSSSLFEDPHTFEPQRWLDAFSEKGNSSLDKYLVAFSRGQRSCTGISLAWCELYISFATLLRQLDM
EYLADENDSVLKWRDCFQALYYGRHLRVRCVRRTS*
>CYP5064A2 Aspergillus oryzae RIB40 = Aspergillus
flavus
AP007159.1
join(1096818..1097070,1097124..1097466,1097500..1098547)
This gene seems to have an AT boundary instead of GT at
intron 3
49% to CYP5064A1 partial seq.
1096818 MDFGGILLHLEARSMATVLIAGLLVYWVGSAIFLAVVHPLAKFP
GPKLAAASDWWLVYHEWFLGKSLTDILFDLHQNY (1) 1097052
GPVVRYGPYR (0)
LHFSSMQAYSDIYNVKSKWDKDPEVYKAIVDTSSAFGLRNYH
EAKERRDLIWPFYSRQSVQRMQKAINRQ (0)
1097494 ISFLVDQLDKQNQEGKLSNMS
MAFRCLAQDIMADICLGKSFGTLEERDFGSPLIHALDEGLESYVLMKSFPTLRNILYS
ISAMVTLPGEAEFATYGTIVADHVTRGIQQPDTIPPNTMLGFLVPTSSNTAKEAPQPK
LSQGHMTEELQTFVIGAGETVASAMVQGLSGILQSPDLYKNVYEEIVQVW PETDGPVP
PIEVLEKLPLLTAVIKEALRLTHGVVTPLARVISAGGACIDGHHVPGGTSVGTSHVFI
HMSSDYYDAPDEFRPERWLGSSSDKHLVAFSKGPRGCMGINLAWCQLYLVLATLVRTV
QMEYPADLNDIKIKWKDCFQPLYYGRPLQVRCTRAEGHS* 1098547
>CYP5064A2 Aspergillus flavus
AAIH01000146.1 Aspergillus flavus = AP007159.1 Aspergillus
oryzae
only 1 aa diff to CYP5064A2 of Aspergillus oryzae
AFL2G_06876 revised
20049
MDFGGILLHLEA
20013
RSMATVLIAGLLVYWVGSAIFLAVLHPLAKFPGPKLAAASDWWLVYHEWFLGKSLTDILF 19834
19833 DLHQNY
(1) 19807
19730
GPVVRYGPYR (0) 19701
19642
LHFSSMQAYSDIYNVKSKWDKDPEVYKAIVDTSSAFGLRNYHEAKERRDLIWPFYSRQSV 19463
19462
QRMQKAINRQ (0)
ISFLVDQLDKQNQEGKLSNMSMAFRCLAQD 19283
19282
IMADICLGKSFGTLEERDFGSPLIHALDEGLESYVLMKSFPTLRNILYSISAMVTLPGEA 19103
19102
EFATYGTIVADHVTRGIQQPDTIPPNTMLGFLVPTSSNTAKEAPQPKLSQGHMTEEL 18932
18931
QTFVIGAGETVASAMVQGLSGILQSPDLYKNVYEEIVQVWPETDGPVPPIE
VLEKLPLLTAVIKEALRLTHGVVTPLARVISAGGACIDGHHVPGGTSVGTSHVFIHMSSD
YYDAPDEFRPERWLGSSSDKHLVAFSKGPRGCMGINLAWCQLYLVLATLVRTVQMEYPAD
LNDIKIKWKDCFQPLYYGRPLQVRCTRAEGHS* 18320
>CYP5065A1 Fusarium graminearum FG10571.1 AACM01000442
FGcontig1.442_scaffold7
MVVKLFVYAAVAVGLTYLVLIFPRLQQEYKLWSHRSQLPPGPKTIRTGIR
KPWLWFQELSQQYGDVVYLQLGPTPTIILGSAQAAWDLLEKRGAVFSSRP
RFIMGGELLSGGMRGLMAPYSSYWRRWRKLLHSGFMQRQSETYRPIQSLE
SKVLMHELLKSPHDFRTHLERYAASVIVTVTYGRRVEDVRSDIVVKRNGE
AMERLTMVNIPGKYAVERYPALKYIPSFLAPWKKQVLQQREKDIQLYTEL
MNEVREKVTRDTAPTCFAKHLLEEQHNLGMTDLEIAYTAGSPFGAGVETS
AGSLASFLLACVKFGPQFIPKAQEELDRVVGNDRLPTFDDLPKLEYVRAI
ASETLRWRPVAVLGGTPHASTADYVYKGMFIPKGSTIIAPLWTLHLNEAD
FPQPHEFRPERFMEERDYPGTLGHSAFGWGRRVCPGMHLGAASVTLNIAR
ILWGFEVNPEKDEKGRDIEVDIFAYSEGFNSSPLPFPCSITPRSTNHTEV
IEREHENALDDLVEYTAIASKVS*
>CYP5065A2 Nectria
haematococca
e_gw1.229.8.1
old name CYP546B2
Necha1/scaffold_229:6813-8646
86% to CYP5065A2 old name 546B1
MVVKILVYAAVAVAFAYLALVFPR (0)
LKQEWKLYSHRSQLPPGPKVIRTGIRKPWLWFQELSQQYGDVVYLQ
LGPTPTIVLGSAQAAWDLLEKKGAIFSSRPRFIMGGELLSGGMRGLMAPYAGYWRRWRKLLHSGFMQRQS
ETYRPVQSLESKVLMHDLLRSPEDFRTHLERYAASVIVTVTYGRRVEDVRTDIVVRRNAESMERLTMVN
(2)
IPGKFAVERYPALKYVPSFLAPWKAEVLQQREKDIRMYTELMDEVRDKVAQ
GVAPTCFAKHLLEEQANLGMSDLEISYTAGSPFGAGVET (0)
SAGSLASFLLACAKFGPQFIPRAQEELDRVVGNDRLPTFDDLPKLEYIRAI
ASETLRWRPVAVLGGTPHASTADHVYKGMFIPKGSTIIAPLWT (1)
LHLNEADFPEPHEFKPERFMEERNYPG
TFGHSAFGWGRRICPGMHLGSASVAINIARILWAFEVNPAKDEKGRDVDVDI
(2)
FAYSEGFNSVPLPFPCSITPRSSSHAEVIGQEYQDALEQLTAYTATTSKIS*
>CYP5065A3 Fusarium oxysporum
90% to CYP5065A1
FOXG_04882
MVVKLILYAVVALGLTYLALIFPRLQQEWKLYSHRSQLPPGPKTIRTGIRKPWLWFQELSQQYGDVVYLQLGPTPTIILG
SAQAAWDLLEKRGAVFSSRPRFIMGGELLSGGMRGLMAPYASYWRRWRKLLHSGFMQRQSETYRPIQSLESKVLMFELLK
RPADFRMHLERYAASVIVTVTYGRRVEDVRSDIVVRRNAEAMERLTMVNIPGKYAVERYPALKYLPTFLAPWKKEVLQQR
QKDIQLYTELMDEVREKVAKGTSPTCFAKHLLEEQESLGMSDLEIAYTAGSPFGAGVETSAGSLASFLLACVKFGPQFIP
KAQEELDRVVGSDRLPTFDDLPMLEYVRAITSETLRWRPVAVLGGTPHASTADHVYKGMFIPKGSTIIAPLWTLHLNEAD
FPEPHEFRPERFMEKREYPGTLGHSAFGWGRRICPGMHLGAASVTLNIARILWGFEVNPEKDEK
GRDVDADIFAYSEGFN
SSPLPFPCSITPRSVKHAEAIESEHGNALEDLREYTAVTSKIS
>CYP5065A3 Fusarium verticillioides
96% to CYP5065A3 Fusarium oxysporum = ortholog
FVEG_03262 revised
MAVKLILYAVVALGLVYIALIFPKLQQEWKLYSHRSQLPPGPKTIRTGIRKP
WLWFQELSQQYGDVVYLQLGPTPTIVLGSAQAAWDLLEKRGAVFSSRP
RFIMGGELLSGGMRGLMAPYASYWRRWRKLLHSGFMQRQSETYRPIQSLE
SKVLMFDLLKRPADFRMHLERYAASVIVTVTYGRRVEDVRSDIVVRRNAE
AMERLTMVNIPGKYAVERYPALKYLPSFLAPWKKEVLQQRQKDIQLYTEL
MDEVREKVAKGTAPTCFAKHLLEEQESLGMSDLEIAYTAGSPFGAGVETS
AGSLASFLLACVKFGPQFIPKAQEELDRVVGSDRLPTFDDLPKLEYVRAI
ASETLRWRPVAVLGGTPHASTADHVYKGMFIPKGSTIIAPLWTLHLNEAD
FPEPHEFRPERFMEKREYPGTLGHSAFGWGRRICPGMHLGAASVTLNIARI
LWGFEVNPEQDEKVRDIDVDI (2)
FAYSEGFNSSPLPFPCSITPRSVKHAQVIESEHDNALEDLMEYTAVTSKIS*
>CYP5066A1 Aspergillus fumigatus
AAHF01000014
no introns 89% to CYP5066A2 in CYP64 clan
756944..758524
locus_tag="Afu8g00220" seventh P450 of 8 on this
accession
89% to 5066A2
Note: CYP5066A and CYP5067A are close in Aspergillus
fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA
dioxygenase
they are probably working in a pathway.
MERLPLSPAVLFLIIVLPILYLWIRYTAPARPHGKHLSLPPGPP
RLPKIGNLHQVPRQIPWKKYKEWSDTYGPIMSVQLADTIAVVFSSWDLIKNHIERRNT
IYSSRPSVPFFLHATGGLNASILPYGPEWKLQRAIRSSVLKPSMTVKYRDVQHVETTQ
LLHELLSTNDFPVCLRRCIASVFLTVAYGERCVDHAGLEAIDRLEELNRAIALHAEAL
FSGAAGILTQLVLPKALVDRLPVRWKKDADMLHNRLTADLVARTRAALVRPGWNWVKE
FSMKDGIGSGDGDGEQGSKVELKRLAYMVGSLYEASMAASQALRVIILAGLLHPDATR
RMHDELDAVVGTGRLPDFHDAAQLPYTQAFIKEAMRWRSLTPMGSPRATSDEDECRGY
HIPCGATVLVNVWAINHDEAIFLDPFAFQPERWIENPDLPQLMYGMGQRACPGRHMGQ
DSLFLATARLFWAFDMALPDGADPIDQERFLDSGTTLAAFLPDFEVRFTPRSEKYQEV
IENSMAVLPDVLSISATP*
>CYP5066A1 Neosartorya
fischeri NRRL 181
AAKE02000012.1 ctg_1099437635460, whole genome
89% to CYP5066A1 = ortholog, no introns in CYP64 clan
Note: CYP5066A1 and CYP5067A1 are close in Aspergillus
fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA
dioxygenase
they are probably working in a pathway.
NFIA_093730
28112
MERLPLSPAVLFLTITLPILYFWILHTSPARHHGKQLPLPPGPPRLPKIGNLHQVPRQIP 27933
27932
WKKYKEWSDTYGPIMSVQLANTIAVVFSSWDLIKTHVERRNTIYSSRPSVPFFLHATGGL 27753
27752
NASILPYGPEWKLQRAIRSSVLKPSMTIKYRDVQSMETTQLLHELLSTNDFSVCLRRCIA 27573
27572
SVFLTVAYGERCADHAGLEAIDRLEELNRAIALHAEALFSGAAGILAQLVLPQALVDRLP 27393
27392
VRWKKDADILHNRLTADLVARTRAALARPGWNWVKAFAIKEGTGSGEGDGEQGREVGLKR 27213
27212
LAYMVGSLYEASMAASQALRVIILAGILYPDATRRMHDELDAVVGKDRLPDFNDAAQLPY 27033
27032
TQAFIKEAMRWRSLTPMGSPRATSDEDECRGYHIPRGATVLVNVWAINHDEGVFLDPFTF 26853
26852
KPERWIENPDLPQLLYGMGQRACPGRHMGQDSLFLGTARLFWAFDMALPDGAEAIDQERF 26673
26672
LDSGTTLAAFLPDFEVRFTPRSEKHREVIENSVVVSSDVSSVTVAT* 26532
>CYP5066B1 Uncinocarpus reesii
43% TO CYP5066A2
UREG_07662.1
MAIKYEVSRYRFYCSHLNKLPLPPGPRGLPFIGNLHQAPKDLAWEGYKKWSDKYGPIMSVNNGGVITIIISSHDIVKNFL
EKHNAVFSSRPQLLVLERALKGLTTPALPYGQKWLVHRALRAAVLKPSMAIKYRGIQDLESKQLLFDLLHNEDFTQCLRR
HASSLFLGIAYGHRFPEEDPESLDIDKAVAQLGGISESMFQGTAMLREFFPILRFLPGTDKWRKQLDEVGDKLADIYVAR
LRAALKTPAWNWAKEYIRRPEAKGMDELELAFCIGSTYQASLTPYEIIRIIMLAAILHPDEALKLQSEIDRVVGEDRLPG
WEVRDNLPWVRAFIWESLRWHAFSPLGAPRAASKEIEYKGYRIPKGATIVLNHFAMDHDENIYKDPFVFRPQRWIDNPDL
PHIIFGFGLRGCPGQHLARDLLYLNTARLFWAYNIGRPFEGGRQVDLDAEALMRPRGGGSAFNQVPHFKASVTVRDPKRR
AIIEEAWATCEKDEQKILEEAMPMANGRENGKNS
>CYP5067A1 Aspergillus fumigatus
AAHF01000014
most like CYP68 family, may be a subfamily of CYP68
join(752285..752491,752557..752673,752735..752834,
752888..752956,753007..753597,753667..754008,
754032..754078) model revised at intron 4
locus_tag="Afu8g00240" sixth P450 of 8 on this
accession
37% to 68A1 Gibberella fujikuroi, best hits all CYP68
Note: CYP5066A4 and CYP5067A1 are close in Aspergillus
fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA
dioxygenase
they are probably working in a pathway.
METLDAIQLPYLGVVGASLIVILGIILLFPLGSDPFITINQHPRDLFQTKAKQQFEYNAAALLNEGLQT
(0)
GHSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDP (0)
VLLVDLPGLESMFQGSLHNQVPPMAVRALNKEL (1)
VHLTPSLSEEAMNCLQTRWTDS TGTC(0)
TEWHGVSIPETVLALIAQMTTRALLGPELCRNPEWLDIAKSFTTNRAIAVAAVQS
WPSFLQPVIHWFLPPCRALRRQIQCARNIILPALERERRAYCSDQPTKREFSNLVFID
QYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIEPLREEVVSVVGNHG
LHRHSLRKLTLMESVMKETQRLEPAVI (1)
IGMFRLAKEKVTLKDGTVVPKGTNIAFANDL
RFDPEMYLEPETFDGYRFQRMREDPAKIDLAPFTKTRMSHLAFGHGKHACPGRFLACD
EAKLILCHILLNYDIRAVEGSPPEL (1)
PGSWGNDVGEKTAGD*
>CYP5067A1 Neosartorya
fischeri NRRL 181
AAKE02000012.1 ctg_1099437635460, whole genome
92% to CYP5067A1 = ortholog
Note: CYP5066A2 and CYP5067A2 are close in Aspergillus
fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA
dioxygenase
they are probably working in a pathway.
NFIA_093750 revised
33060
METFDAIQLPYPGVVGASLLVILGIILLFPLDTGHFISINQHPWDFFQTKAKQEFEYNAA 32881
32880
ALLNEGLQT (0)
32788 GRSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDP
(0)
VLLVDLPGLETMFQGSLHNQVPPMAVRALNKEL
(1) 32512
VHLTPFLSEEAMNCLQTRWTDSAGTC (0)
TEWHDVSIPETVLALIAQMTTRALLGPALCRNPEWLDIAKSFTTNRAIAV 32193
32192
AAVQSWPSFLQPVIHWFLSPCRALRRQIQCARNILLPVLERERRSYRSDQPTKREFSNLA 32013
32012
FIDQYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIQPLREEVVSVVGKN 31833
31832
GLHSHSLRKLTLMESVMKETQRLEPAVI (1)
IGMFRLAKE 31653
31652
KVTLKDGTVIPKGTNIAFANDLRFDPEMYPEPETFDGYRFQRMREDPEKIDLTPFTKTRM 31473
31472
SHLAFGHGKHACPGRFLACDEAKLILCHILLKYEIRAVEGSPPEL (1) 31338
31314
AGSWGNDVGEKAAGE* 31267
>CYP5067A2 Aspergillus terreus
52% to CYP5067A1
ATEG_10307.1
MEQYIKLSFPSAVTECIFGLLIIGTFVMFGSRKNTPKLVPTLNDHEWDIFRRKAKKNWEESAESILRAGLQK
(0)
GYPGFQVITSMGTKLVMRDQYAEELRNDDRFAVYEAFKD (0)
VALVELLG
FETWVPGGFHNHVSTPVVHALNRNITRLVQPMSEEAAHCLKVQWTDNPAWHSVSIHDTVLRLVAQITSRLFIGQEICRDP
EWQDIAKDFSTKRVIAIQAIHAWPSLIHPVIHWFLPVCHDVRKLIRRAKSILLPIFELERCNRKSGRESNNVFSTLSFID
EYANGRPYDPTMAQLRLTGVSIHSTSDLVKKVIARICEHSELIPALRAEIISAAENCGLQHSSLLKMPLMESIMKETQRL
EPPAL (1)
IVSMFRMAKETVTLQDGTQIPKGAQLAFANDLRLDRSTYPDPETFDAYRFLRMRDD
PAQSKQVPFTKTTYSHLAFGHGKHACPGRFLVCNEVKVILSHILMKYDIKAIDGEG
AGLCKSGMFVFLDPRARMFVRRRQEEIPI*
>CYP5068A1 Aspergillus fumigatus
AAHF01000014
complement(618220..619713) no introns
locus_tag="Afu8g00740" fourth P450 of 8 on this
accession
CYP65% to CYP5068A2
32% to 663A1 A. nidulans in the CYP64 clan
MELVAPTLLAIVLVCCCLHLLRSQ
ASRLPLPPGPTLLSRPFPEK
DIATTFQKWNQRYGPVISFRVGSRTFVVLGTRQAAQDLLEKRGSIYSSRPPSVWMEKY
LNKGLAAAFMPYGHEWRLNRRLHGSLLSAHHTNAYRSLQDIQSKQLLHDFLSTNDFSH
CFHQYTSNVMFTLVYGKGRGKDDNDHRRLEQINELAGFVLQGASFWTFLMDLFPILDY
VPRIFWKWRTEAARLHDRTMVVYRECCEEALTAECWHWSKEVTQKPDIMQLPWDNVCY
SLGELYVAGIHTTKMVLELCVMVSILYPDVVCKAQQELDSMVGADRLPSFDDMERLPF
INAIISELLRWRPISPIAVPHAAIQDDEYMGYFIPKGATVIANQFGMNMDDAFFYDPS
SFHPERYVENPDLPVSAFGFGRRACPGHRLARSSLFIVISRLLWAFHITSANKEPLTE
ESSPAAVKATFRVRSPHRQKIIERDWALAEKDERIVLSQIESRIRGK*
>CYP5068A1 Neosartorya fischeri
92% to CYP5068A1 Aspergillus fumigatus =
ortholog
NFIA_094170
MESVAPTLLAIVLVCCCFHLLRPRTSRLPLPPGPTLLSGPFPEKDIATTFQKWNQRYGPVISFKIGTRTFVVLGTRQAAQ
DLLEKRGSIYSSRPPSVWMEKYLNKGLAAAFMPYGPEWRLNRRLHGSLLSAHHTDAYRHLQDIQSKQLLHEFLSTNDFSH
CFHQYTSNVMFTLVYGKGRGRDDNDHRRLEQINEMAGFVLQGASFWTFLMDLFPILDYVPRIFWKWRTEAARLHDKTMIV
YRECCEEALTAECWNWSKEVTQKPDIMQLPWDNACYSLGELYVAGIHTTKMVLELSVMVSILYPDVVRKAQQELDSVVGV
DRLPSFDDMERLPYIDAIISELLRWRPISPIAVPHAVIQDDEYMGYFIPKGATVIANQFGMNMDDAFFYDPSRFHPERYV
ENPDLPVSAFGFGRRACPGHRLARSSLFIVISRLLWSFDITSADKEPLTEESSPAAVKATFRVRSPHRQRIIEKDWTLAE
KDERVVLSQIESRIHGK*
>CYP5068A2 Aspergillus oryzae RIB40
AP007155.1 genomic DNA, SC003
complement(2295650..2297146) CYP65% to CYP5068A1
MELIIGLCLLAPLLFLYTPLRRFIGLN
2297065
ASELPLPPGPTLLSGPFPEKDIAKTFQKWNKKYGPIVSAKIGAQQFIILGSRRAAQDLLE 2296886
2296885
RRASIYSSRPASKFLDKYLHKGLASAFMPYGAQWRLHRRLGSSLLSERASTAYRQLQDFE 2296706
2296705
SKRLLHEFLSTNDFSEAFLSYTSDIMFTLVYGKGRGKDDSDHKMLYQINEMATFVLQKAS 2296526
2296525
FGTILLDLFPMLDWLPHCFLTWRKKAEELHYKTKEVYTECGNIALGGDCWNWSHEVSQRS 2296346
2296345
EAKELPWEDVCYALGELYVAGIHTTKMVLEILIMVCVLHKEVKQKAQAELDSVVGEDRLP 2296166
2296165
SPDDLEKLPYIRAIVSELLRWRPISPIGVPHAVIQDDEYMGYRIPAGATVVANQFGMNMD 2295986
2295985
EATFDNPAAFNPDRYLNNPDLPVSAFGFGRRICPGHRLARGSLLIVTSRLLWAYDITSAQ 2295806
2295805
GDADLGDEYSPSSVKAVFQPRSVKHEQVIKKEWEESDKDEKRILERIRDRI* 2295650
>CYP5068A2 Aspergillus flavus
100% to CYP5068A2 Aspergillus oryzae
AFL2G_02173
MELIIGLCLLAPLLFLYTPLRRFIGLNASELPLPPGPTLLSGPFPEKDIAKTFQKWNKKYGPIVSAKIGAQQFIILGSRR
AAQDLLERRASIYSSRPASKFLDKYLHKGLASAFMPYGAQWRLHRRLGSSLLSERASTAYRQLQDFESKRLLHEFLSTND
FSEAFLSYTSDIMFTLVYGKGRGKDDSDHKMLYQINEMATFVLQKASFGTILLDLFPMLDWLPHCFLTWRKKAEELHYKT
KEVYTECGNIALGGDCWNWSHEVSQRSEAKELPWEDVCYALGELYVAGIHTTKMVLEILIMVCVLHKEVKQKAQAELDSV
VGEDRLPSPDDLEKLPYIRAIVSELLRWRPISPIGVPHAVIQDDEYMGYRIPAGATVVANQFGMNMDEATFDNPAAFNPD
RYLNNPDLPVSAFGFGRRICPGHRLARGSLLIVTSRLLWAYDITSAQGDADLGDEYSPSSVKAVFQPRSVKHEQVIKKEW
EESDKDEKRILERIRDRI*
>CYP5068A3 Aspergillus clavatus
72% to CYP5068A1
ACLA_044830
MESIQLAIAIAVLVSLAIYCWRLNPGRVAKLCLPPGPTLLSGSLPGKDIATTFQKWSREYGPVVSFSIGGRTFIILGTRQ
AAQDLLEKRGNIYSSRAPSVWMDKYLYKGLAAAFMPYGAEWRLNRRLHGSLLGVHQTNAYRYLQDIQSKYLLHEFLSTDD
FSHGFHQYTSNVMFTLVYGKERGRDNGDHRRLEQINDMASFILRGASSWTLLLDLFPILDRLPRFWWTWRTEAATLHDKT
KAVYRECCETALTADCWNWSREVTGKRDIMALPWDHVCYSLGELYVAGIHTTKMVLDIFVLVSVLYPTVVSKAQRELDSI
VGSDRMPSFDDLDQLPFINAIISELLRWRPISPIAVPHAVMQDDEYMGYFIPRGATIVANQYGMNMDESIFGDPTRFRPE
RYIENPELPVAAFGFGRRACPGHRLARSSLFIVISRLLWGYDITSADKQGPLESSSPSSVKAAFHVRSPRRQGIIEQDWD
LAEKDDGVILDEIQSRFRRT*
>CYP5068B1 Aspergillus oryzae
GenEMBL BAE63024.1
39% to
CYP5068A2, 41% to 5068A1
MVSYEWCLDSFNPFGITRNSLCFFFLVALCLCWSSSAWSSKQQRLPPGPPALPVIGNLHQMPRRNRWRAL
QRWHKLYGPIISLRLGQRIAISLGTHKVARELLELRGNNYSSRPRFVVAGDYVSEGLHSILLPYGNQWRI
HHRIQRELLTNHRTQAYRYLQDIESKQIVYDMLKSSDFVGHFRRYTSSVMFTLAYGKRLESPGRHEIAEA
SKITENISLAADQAKNMIVEVYPVLDYIPRCFAPWKRIGTRLHAQTVQFFEQQMLEGLRSPAWNWSKHII
ALNETKDLSNKEIVYILGALYEAGSETTATVLQIFVLASVLHPECIGHAQLELDESVGNDRMPTFEDMPR
LPYLNAFIKEVLRWRPIAPLGIPHAPSKIGEFMGYSIPEGATIFPNNWTLDLDDAVFRDPYAFKPERWLE
DPNLPLSTFGFGRRACPGKQMAENSLYIAIARLIWGYNFHHAYENGLRVELDPWDMKEGVVSPPATFSAV
LSVRSSVHQRLIELEWDSAEKDVNGILGQIESLMGSRAAAQKDSSA
>CYP5068C1 Aspergillus niger
e_gw1.19.56.1|Aspni1
40% to CYP5068B1
MDKHLNLFVFISIFASFLLVTYSLVSKKRNHNLPDGPRPLPIIGNIHQMLSQRLMEVVHKWHQDYGTMVAFRYGQQQAIS
ISSFEIIQDLLVKRGAIYSSRPPFIIASRMSLGFNSAIMPYGKQWQNHHRIMSSFLDTTAVGRYRSLEDMESKQALAELL
ESDDFEASLSRYAGSILMTLGYGIRLETTDNDIPAKLHAMNRHPFEAMGNTYYSLVELFPVLDKLPSCLAPWKQFSANVE
REAAEFHMEHFEIGKSASTWNWVQNALHSSAGSRVSSKELAYVIGTLQQAGFEATLTILRLVVKTIVLHPHCLREAQQEL
DRVVGPDRLPSFGDIPQLSYINAILNEAMRWQTPIPFAIPRTTTQDDEYKGYHIPSGTVIIPNVWAMMLNPEVFPDQDKF
KPERWIENPNLDHSPFGFGRRICPGRHLGWDSVFILTARLLWAYNITHSYKDGKRIEIDPRDIELTFTAAPRPFKASFQV
RGSKRQEIIE
>CYP5069A1 Aspergillus fumigatus
XM_741366 mRNA PLN 06-FEB-2006
41% to 5050A1 but only 34% to 5050B1, keep in a separate
family.
Aspergillus fumigatus Af293 O-methylsterigmatocystin
oxidoreductase
MDPFKAIDLPLPPHFVAALGRPTVLVGFACVFLFSQLLVWTAKY
SRKKSKGLADIPGPSGWPIIGIGLDLPARPRKLLNSWANQFGDTFKVRVGWYNWVFFN
HPDAVKEVFDRQAAVTSGKPPLPIAQEYCLRGDGVLPMTYNAKWKRLHAFLKQLLNAK
ASAAFIPSQEFEIKQLLWDLSHEAGKNSTDFYMHIRRMTFSIVMTSAYGLRIPQWDCQ
EVRDVYGNMRMLSIILSPGVFWIDVFPPLNWLPRFLFPSWPKAKFMAQKMHANKMRHW
NNLKERIALGNAPDCFAKDLMESNYRDYGLEEETVSWLASAVPEAGAETTASALNGMI
RYLAMFPEAQARAHEEVTRILGDGRMATLADEPQMPYIKAVIKETLRLCPVATTGLRR
MADGDVKYRDYVIPKGTILLANLNALHWDPERFPDPFSFKPERYLNHPHRSAVYAAGG
DIMARDHFTFGAGRRICPGIHLAENGLFLAVSNLIWAYEFKLPLDEKGNEIPLDISDE
GFMEGAIRVPKQYTVRILERNPARSRLIRESWEQAQKDGYILRGVHVDADGGVRGSAK
VKA*
>CYP5069A1 Neosartorya fischeri
98% to CYP5069A1 Aspergillus fumigatus
= ortholog
NFIA_030840
MDYFKAVDLPLYFKAADLPLPPHFVSALGRPTVLVGFACVFLFSQLLVWTVKYSRKKSKGLADIPGPSGWPIIGIGLDLP
ARPRKLLNSWATQFGDTFKVRVGWYNWVFFNHPDAVKEVFDRQAAVTSGKPPLPIAQEYCLRGDGVLPMTYNAKWKRLHA
FLKQLLNAKASAAFIPSQEFEIKQLLWDLSHEAGKNSTDFYMHIRRMTFSIVMTSAYGLRIPQWDCQEVRDVYGNMRMLS
IILSPGVFWID VFPPLNWLPRFLFPSWPKAKFMAQKMHANK MRHWNNLKERIALGNAPDCFAKDLMESNYRDHGLEEETV
SWLASAVPEAGAETTASALNGMIRYLAMFPEAQARAHEEVTRILGDGRMATLADEPQMPYIKAVIKETLRLCPVATTGLR
RMADGDVKYRDHVIPKGTILLANLNALHWDPERFPDPFSFKPERYLNHPHRSAVYAAGGDIMARDHFTFGAGRRICPGIH
LAENGLFLAVSNLIWAYEFKLPLDEKGNEITLDISDEGFMEGAIRVPKQYTVRILERNPARSHLIQESWEQAQKDGYVLR
GAHVDADGGVRGSAKVKA*
>CYP5069A2P Aspergillus oryzae
GenEMBL BAE60165.1
76% to 5069A1
MDLYKAVVLDLHLSPGLISAIHKPTVLVGIACALFFSQLLFWTAKYSHKKTKGLADLPGPSGWPLIGMGL
DLPVRPRELLNRWAAQYGDVFKVRVGWYNWVFFNSPDAVKEVFDRQAAVTSGKPPLPIAQDYCLRGDGVL
PMTYNAKWKRLHAFLKQLLSAKASAAFIPSQEFEIKQLLADLSHEAGKNSTDFYMHIRRMTFSIVMTSAY
GLRIPKWDCQEVRDVYGNMRMLSIILSPGMFWID VFPPLNWLPRFLFPLWPKAKFMAN*MHSNK
MRHWDNLKDRITAGN
APDCFAKDLIESNHRD*GLEEETVSWL
ASAVPEAGPETTASALNGLIRYLAMFPDAQARAHDEVTRVLGDTRMATLADEPNMP
YIRAVIKETL
RLCPVATTGLRRMADGDVHYRDHLIPKGTILLANLNTLHWDPERFPHPFHFKPERYLNHLHRSAVYAAGGDILARDNFTFGAGR
RICPGIHLAENGLFLAVANITWAYEFKLPLDDQGEEIPLDITDEGFMEGAIRVPKQYTVRILERNAAR
SRLIRSEWDQAQQAG YVLRGSHVDVNGGVGGGSKTAAS
>CYP5069A2P Aspergillus flavus
98% to CYP5069A2 Aspergillus oryzae
MDLYKAVVLDLHLSPGLISAIHKPTVLVGIACALFFSQLLFWTAKYSHKKTKGLADLPGPSGWPLIGMGLDLPVRPRELL
NRWAAQYGDVFKVRVGWYNWVFFNSPDAVKEVFDRQAAVTSGKPPLPIAQDYCLRGDGVLPMTYNAKWKRLHAFLKQLLS
AKASAAFIPSQEFEIKQLLADLSHEAGKNSTDFYMHIRRMTFSIVMTSAYGLRIPKWDCQEVRDVYGNMRMLSIILSPGM
FWID VFPPLNWLPRFLFPSWPKAKFMAN*MHSNK
MRHWDNLKDRITAGN ()
APDCFAKDLIESNHRD*GLEEETVSWLAS
AVPEAGPETTASALNGLIRYLAMFPDAQARAHDEVTRVLGDTRMATLADEPNMP
YIRAVIKETL
RLCPVATTGLRRMADGDVHYRDHLIPKGTILLANLNALHWDSERFPHPFHFKPERYLNHLHRSAVYAAGGDILAR
DNFTFGAGRRICPGIHLAENGPFLAVANIIWAYEFKLPLYDQGEEIPLDITDEGFMEGAI
RVPKQYTVRILERNAAR
SRLIRSEWGQAQQAGYVLRGSHVDVNGGG*
>CYP5070A1 Aspergillus oryzae RIB40
AP007157.1e genomic DNA, SC023
480458..482071 no introns
in the CYP56/547 clan about 33% to CYP617A1
MALFTFRLLPLVCTASIAIYVLSRFMHFETKSTGALTYSITFII
YLLYWLYIYPYHLSPLRHVPTVPGCPLWGHVFEIFNAEIGAVQQKWHKTHGPIVRYFY
PFGKEILSVVDNSALKHILVEASYNYEKTASNRKFLSRLFGEGILTAGGKVHAQQRKA
LNPAFSISAIKALAPAFWDYSCSMSSYWEQDIKESSDDSVSLDISDWASRATLDIIVA
VGFGAKIDTLHNSTAPLIEAFRTVFRFDAVAKLLAVLHILFPIVRYLPIKENREVDAA
KRTLFEFASGLIQEKEANINSTGNNILSQLVRGDRKPQAAGEDIFSRVICDQIATFLG
VGQDTSATWLSWTLHLLSKHQHMQVKLREEIRSHFPFLFRGATHEKIDFTEVDVDRLP
YLNNVCRESLRFIPPIPFVSREAARDERLGEYFIPKGTVIHIPINTIHRMPEYWGPNS
NAFDPDRWNCLPASYTNNAFLPFTQGPRGCIGRKFADTEVKTILCCLLSKFQFSPDPA
VQDPEELKRYRIVQKSQYGIRLKVSKLDG
>CYP5070A1 Aspergillus flavus
99% to CYP5070A1 Aspergillus oryzae
AFL2G_04072
MALFTFRLLPLVCTASIAIYVLSRFMHFETKSTGALTYSITFIIYLLYWLYIYPYHLSPLRHVPTVPGCPLWGHVFEIFN
AEIGAVQQKWHKTHGPIVRYFYPFGKEILSVVDNSALKHILVEASYNYEKTASNRKFLSRLFGEGILTAGGKVHAQQRKA
LNPAFSISAIKALAPAFWDYSCSMSSYWEQDIKESSDDSVSLDISDWASRATLDIIVAVGFGAKIDTLHNSTAPLIEAFR
TVFRFDAVAKLLAVLHILFPIVRYLPIKENREVDAAKRTLFEFASGLIQEKEANINSTGNNILSQLVRGDRKPQAAGEDI
FSRVICDQIATFLGVGQDTSATWLSWTLHLLSKHQHMQVKLREEIRSHFPFLFRSATHEKIDFTEVDVDRLSYLNNVCRE
SLRFIPPIPFVSREAASDERLGEYFIPKGTVIHIPINTIHRMPEYWGPNSNAFDPDRWNCLPASYTNNAFLPFTQGPRGC
IGRKFADTEVKTILCCLLSKFQFSPDPAVQDPEELKRYRIVQKSQYGIRLKVSKLDG*
>CYP5071A1 old name = CYP59B1 Fusarium
graminearum FG02366.1 AACM01000117 FGcontig1.117_scaffold1
MALRWAGILLLTSISYFAIKLYQQRVWFRRTVEKYNLPTLPGHSWLLGNL
IAVGKIMVAYPADVHGQLMPDFLAREYPEIAEFGVCYIDLWPVSWPMMAT
FHPDIAAQFTQETSRPKHEIIRGQFRPLTGLKDLVLAEGSFWKKWRATFN
PGFSTQNISALVPEFIEEASIWKKYLQQVAKEDKVVRLEDSVMKATCDII
GRSVLGQSLGIQSGVDDKIFPTLKGAIALLVTDWSPPNWSRLLDPFRGRR
LASLNQKLRSQLKFLIESQLENHASIQGPKTVNGLAIRTYLKDTGKEDIS
KSGVDTEFLDVTIENLKIFLFAGHDTTASTLCFAYNYLHHHPDVLAKLRK
EHDEVLGPDPNSATSIISESPTILNQLVYTTAIIKETLRLEPPIGSCREG
SPTFFLRHPETGQQLPTDGFILFSASKAIHRNPKFWPNPDKFMPERWLEQ
DFHRTAYRPFELGPRGCIGQELALTELRLLLAMTVRDLEIVPAYKDEADT
LYXXXXXXXXXGYQAFQAHMPGELTAHPSKGMPVRVRLRKV*
>CYP5072A1 # is same seq as CYP5030A1
no sequence
>CYP5073A1 old CYP68M1 Aspergillus nidulans AN8141.1
39% to 68D1 LEFT OUT OF TREE
MALYDVFSTSLTDPLHLTLGILSISLPLLWYLRRGKQTQEQAQSNAPRSW
PFNPASLDRKESESPILTFGNSIILPNRYAHEIRNNDLLSFRDGLEKDFL
TTVPGLEAMFTGTFHNHIVWDTASAFSRKLGALIEPLTTETGIFLRENWS
DDTEWHAISLNETMNLLIAQLTARIFIGEELCRNRDWIQNAISYTAHRTA
AMKELHWYGRLIPLAHWFLPSCRALRGCVRAGRPFVERVLEARRTTQGKG
EDKSIDALSWIDGVAGENGTKYDATLTQLRLAYAAVHTTSDMMTKVVAAL
CEHQELIQPLREEIVTVVKEHGWSEAALAKMVLLDSVLKETQRLEPLASF
TLSRIAREPVVLNDGTRIPKGAQVRLTTDNMWNSSVYPDAAIFDGYRFVK
LREQERGANTGTVGGGGGLSFVSVSANHMGFGYGKHACPGRFFAGAETKV
ALCHILLKYDFDLVDRALAGAQTDGMMIWRDKRAMLRVKRREAEIDI*
>CYP5074A1 temp = CYP68P1 Aspergillus fumigatus
AAHF01000006.1
40% to CYP68D2, 41% to 68A1, 42% to 68L1
may be a CYP68 new subfamily or a new family close to
CYP68
join(2240366..2240617,2240858..2240960,2241166..2241768,
2241834..2242254,2243095..2243299,2243359..2243572,
2243792..2244367,2244427..2244655,2244889..2244922)
locus_tag="Afu6g13940" gene model is wrong, two genes fused,
missing exons
Part of a toxin biosynthesis cluster with
another P450 CYP5281A1 and a PKS
43% to CYP68L2
MDSLALGSNWAGGVAIVLFLAPLALHLVSSY
LFPSTSTVINSGRAWDIFRTTAKKRFRSDAARLLQNGFEK (0)
2240686
SPDAFRILTDNGPLLVLSPRYAREVRSDDRLSLDHFIAS (0) 2240802
2240858
EFHPDIPGFEPFKLILDPRNPLNTILKTSLTQAL (1) 2240959
AYMTEDLSVEVADALSTALTDDS (1)
EWHEISPCQTALKLVAQMASKAFIGPEKCRDPKWHNVIITYT
HNVYRAAQALHFWPKFLRPIVARFLPACQTLQAQIAEAREILEPLVAQRRADRACRAA
QGKPVPSRADVIDWLEDSHGDQPYDPVAAQLLLSFAAIHGTSNLLAQALMDLCTAPDL
IRDIRAEITSVLGDAGLTRAALYRLKLMDSALKESQRLAPNRL (1)
LSMGRIAQSDMHLSDGLRIPRGTTLMVSAHAMWEPQIYPDPRRYD
GYRFYKLRQVPGQEGQHQLVSATEKHMGFGYGKHACPGRFFAAAEIKVALCHILL
KYDLEHRGGGPPPRVWSQGIHLFPDPTARIRVRRRKEEISL*
>CYP5074A1 Neosartorya fischeri
93% to CYP5074A1 Aspergillus
fumigatus = ortholog
NFIA_100510
MPLGSNWARGLAIILFLGPLTLLLVSSYLFPSTLTVINSGRAWDVFRTTAKKRFRSDAARLLQNGFEKSPDAFRILTDNG
PLLVLSPRYAREVRSDDRLSLDHFIASEFHPDIPGFEPFKLILDPRNPLNTILKTSLTQALAYMTEDLSVEVADALSTTL
TDDSEWHEISPCQTALKLVAQMASKAFIGQEKCRDPKWHNIIITYTHNVYLAAQALHFWPKFLRPIVARFLPACQTLQAQ
IAEAREILEPLVAQRRADRASRAAQDKPVPSRADVIDWLENSYGDQPYDAVAAQLLLSFAAIHGTSNLLAQALMDLCTDP
DLIRDIRAEIISVLGDEGLTRVALYRLKLMDSALKESQRLAPNRLLSMGRIAQSDMHLSDGLRIPRGTTLMVSAHTMWEP
EIYPDPRRYDGYRFYKLRQASGQEGQHQLVSATEKHMGFGYGKHACPGRFFAAAEIKAALCHILLKYDLEHRDGQPPRVW
SQGIHLFPDPTARIHVRRRKEEISL*
>CYP5075A1 Aspergillus oryzae RIB40
AP007174.1 genomic DNA, SC103
35% to CYP614A1 in the CYP534 clan
join(1244215..1244596,1244662..1245434,1245493..1245996)
1244215
MLLLLLETLALAYVAWSLVAMEINYRRACAMKIPLVRLCIDPQNLLWVILEPH 1244373
1244374
LWPWLDRLPINWGNFGRYSRRGWYFADRGESHRRYGPIWALVTPKEIYINVADSEAIHD 1244550
1244551
IFQRRTDFIRPVEQY (1) 1244595
1244661
TVLEVYGPCISTANTTDWPRHRKVLATPFNESVMSFVWDESVEQTRQMIDIWASPDLDKISS 1244846
1244847
VAKDTRTLSLNVLAAIGFRKSYPFRSGNGNSHREQSDSVSYRDALQTVLDNAILLMIMPR 1245026
1245027
RLLSLSFAPESWQQLAKAATDFKQHMVRMLDEEVQALNEGKAGSGGLMTSFVRAM-NLKQ 1245203
1245204
EDARSKGLTTDEIFGNIFVINFAGHDTTANTLSFGLLLLAAYPEVQDWVAEELLLLTNTK 1245383
1245384
GQYADLFPKLNRCRAVM (0)
1245434
1245493
LETLRLYPPIPSLPKWTNDQAQPLKVGDRTIMIPPKVGINPSLLTMHIDPQHWEDPLEWK 1245672
1245673
PSRWITPTKLVRAISIEDEQLITPVRCTYFPWSDGPQNCPGNKFSQVEFVAVIASLFRHH 1245852
1245853
RISPVANAGETFQQTRERVLATTRDVDLQLLLRMKDAERVHLKCRRV* 1245996
>CYP5075A1 Aspergillus flavus
99% to CYP5075A1 Aspergillus oryzae
AFL2G_11923
MLLLLLETLALAYVAWSLVAMEINYRRACAMKIPLVRLCIDPQNLLWVILEPHLWPWLDRLPINWGNFGRYSRRGWYFAD
RGESHRRYGPIWALVTPKEIYINVADSEAIHDIFQRRTDFIRPVEQYTVLEVYGPCISTANTTDWPRHRKVLATPFNESV
MSFVWDESVEQTRQMIDIWASPDLDKISSVAKDTRTLSLNVLAAIGFRKSYPFRSGNGNSHREQSDSVSYRDALQTVLDN
AILLMIMPRRLLSLSFAPESWQQLAKAATDFKQHMVRMLDEEVQALNEGKAGSGGLMTSFVRVMNLKQEDAPSKGLTTDE
IFGNIFVINFAGHDTTANTLSFGLLLLAAYPEVQDWVAEELLLLTNTKGQYADLFPKLNRCRAVMLETLRLYPPIPSLPK
WTNDQAQPLKVGDRTIMIPPKVGINPSLLTMHIDPQHWEDPLEWKPSRWITPTKLVRATSIEDEQLITPVRCTYFPWSDG
PQNCPGNKFSQVEFVAVIASLFRHHRISPVANAGETFQQTRERVLATTRDVDLQLLLRMKDAERVHLKCRRV*
>CYP5075A2 Aspergillus niger
estExt_GeneWisePlus.C_90633|Aspni1
72% to CYP5075A1
MILEALGLLALAYLAWSMVTMEINYRRASSMGIPLVRLYIDPQNVLWMVFEPIIWPWLNKLPINWRNYSFGRYSRRGWYF
ADRGESHKRYGPMWALVTPRDIYINVADPNAIHDIFQRRTDFIRPSQMYKVLEVYGPCISTASWNDWPRHRKVLATPFNE
NAMSFVWDESVEQTRQMLQVWGSSADGHIPSVAKDPRTLSLNVLAATGFRKSFPFQSAKDHQVKSKSPATSEDESEGYRD
ALQTVLDNCILLMVMPRKLLTLPFAPESWHHLGKAAADFKNYMVQMLNEETKALNTGSAGSGGLMTSFVRAMDLKQKVDG
EGKTKTSGSPPKGLTVDEIFGNIFVINFAGHDTTANTLSFGLLLLAAYPEVQDWVAEELDGLDEDNIKEHYGELFPRLLR
CRAVLLETLRLFPPIVSLPKWTNDEPQSLRLGERDIMIPPHVGVHPSLLDMHIHPQYWEDPLTWKPSRWITKSASGDASE
AIITPSRSTYFPWSDGPQNCPGNKFSQVEFVAVMAALLRSHRVHPVANPGESPKETRARVLATTQDVDLQLLLRMTNADQ
VRLACSRVA*
>CYP5075B1 Aspergillus oryzae
GenEMBL BAE58484.1
42% to CYP5075A1
revised
3/19/2009
MLLIIAVALLGWTLYSVFCLVGNIRRIQKIGIPYHVIPCSPVNPLWILLEPLIFFILGLLPFEFGRIKHY
GRRTWQFTDKAQSHMRMGDAWAIATPNEIFVYICDADAITDIIARRADFVRPIELFTLLNVFGPNVATTE
GADWQRHRKIVAAPFNESLNSFVWREALTQAQSMLTTRATAGPSGGLGTDTRTLALNVLAATGFKRSTRF
QSAQEAQSEDPRSYAQSLKTVMLNTFLIMLIPPSVLKFPIFPSWCRRAGEAVEDFKQHMLNMFNTEKTLL
DQGKPGTGTLMSSFVRESTVDPKSNKTVLTLDEILGNIYVINFAGHDTTAGSLTYVLFLLAAYPNIQEWI
AEEIRTVFPNPDRDTWDYKEAFPRLKRCLAVV (0)
LETVRLYPPILALPKSVAPQSTSLRLPESNRTIVLPKGTVVL
PSLLAAQTHPKYWPDEPTTWNPRRWIETSNPTDATTSTPEDHLAGEEIMEPRAGSYFPWS
AGVQNCAGRKFAQVEIVAAMAAWFREYRVRPVREDGEDFEKAQA
RILESTNDSYQLLVMQMRDPDSAKFVWEQVE*
>CYP5075B1 Aspergillus flavus
99% to CYP5075B1 Aspergillus oryzae
AFL2G_01648
MLLIIAVALLGWTLYSVFCLVGNIRRIQKIGIPYHVIPCSPVNPLWILLEPLIFFILGLLPFEFGRIKHYGRRTWQFTDK
AQSHMRMGDAWAIATPNEIFVYICDADAITDIIARRADFVRPIELFTLLNVFGPNVATTEGADWQRHRKIVAAPFNESLN
SFVWREALTQAQSMLTTRATAGPSGGLGTDTRTLALNVLAATGFKRSTRFQSAQEAQSEDPRSYAQSLKTVMLNTFLIML
IPPSVLKFPIFPSWCRRAGEAVEDFKQHMLNMFNTEKTLLDQGKPGTGTLMSSFVRESTVDPKSNKTVLTLDEILGNIYV
INFAGHDTTAGSLTYVLFLLAAYPNIQEWIAEEIRTVFPNPDRDTWDYKEAFPRLKRCLAVVLETVRLYPPILALPKSVA
PQSTSLRLPESNRTIVLPKGTVVLPSLLAAQTHPKYWPDEPTTWNPRRWIETPNPTDATPSTPEDHLAGEEIMEPRAGSY
FPWSAGVQNCAGRKFAQVEIVAAMAAWFREYRVRPVREDGEDFEKAQARILESTNDSYQLLVMQMRDPDSAKFVWERVE*
>CYP5076A1 = old CYP670B1 Aspergillus
nidulans AN0606.1 poor match 32% to 574A1 53 clan
MALSLNAAVVLAGVISHIAYFKQGEHHLYGFFYLKLLLTAMSTATVMLSY
VQGAPWRVALSTVLKLLSAYLFGIYTSLLVYRLLLHPLNRFPGPFPARIS
TVWTSTQLKSNNMHLTLLHYHRKYGPFVRIGSSDLSIAHPDALGPIYGTH
SRCIKGANYELSAPATALQLMRDPEEHHARRRVWSGAFSDRLLRGYEVRI
RKYREKLLDRLSEMSSRKEPVDVTKWFNLYSFDVMGDLSFGRGFEALERG
EEHWAMRLLMATQNFVGLNLPAWAFVLMIRIPGASMDFWRFLEFCGERLL
DRFKNDPEIPDISSSLFVPLKDRNVEDLTIEEKNLLYGDSRLIVIAGSTS
DTTAGTLSAIFYELVQHPEHITKLRDELEPHHLGNDNPKKTEFLHSKIAQ
LDHLNGVINEALRLYPAVPSSLQRKTPPEGVVVDGTYIPGDMHVVCPLYT
IGRSEIAYDHPEDFIPERWYSKPELVRHKGAFAPFSLGHFNCIGRPLALM
NLRVTLAQLIMEFDVKFAPGEDGKQFLADAKDNFVMYFGKLELAFTRRER
QKE*
>CYP5076A2 Aspergillus niger
estExt_GeneWisePlus.C_200209|Aspni1
51% to CYP5076A1 (ferricrocin
hydroxylase?, check for NRPS neighbor)
MVSSMLTAALVGVFSHLTYFRRGEHQLYGTTYTQVFGVLNATAVAYLHVSWGIAWQEALVTVSLHAASYLLGIFSSLLLY
RLAFHPLGAFPGPWPARISDLWLCSQMKNNNRHIKLTELHEKYGPYVRIGPSTLSVIDPKAVNIIHGPSSRCLKSGWYDH
SHPNKSLQTSRDPAEHQQRRRLWSTAFGSKQLRGYEHRVRKYRQQLVDRFVEREGQPVDVTKWFDLYTYDVMGDLAFGEG
FGCLEQGEYHWATQIMMETMDFVGSNLPMWLFRMVLEVPGLKSGWYKFLDYCETRLVERMRNEPDVPDISAALLAPFKGK
EPGKEDQQWLGGDSRLIIVAGSDTTASTLVSLFYELCHHPDEVEKLRAELAPVVNEHGRLGDFYDSDIGHLAHLNGAINE
AMRLYPAVPSGVQRIMPPEGITVDGVSIPGNTTVINPVLAMGRSELSYKKPLEFIPERWYQQPELINDQSAFVPFNIGTY
NCIGKPLALQNLRATVAHLVTTFNVKFAPGNAEKDLIQRSKDCFVLYHGELDLIFTRRK
>CYP5076A3 Aspergillus terreus
57% to CYP5076A1
ATEG_00808.1
MPLSHPLYISAAAGIASHIAYFNKGEHHLYVTQYLKLFLAAIAAITATLHYTQSQPWPHALSTTSHLAAAYLSGLYTSLL
IYRLFLHPLHQFPGPLGSRLSSLYLPTQLNHNLYKHLHAYHTHYGPFVRTGSSDLSIAHPAAVHALYSAASPCTKAAYYD
FTHPGLALQNIRDPAAHAARRRVWARAFSDPLLRGYEARVREYQQRLVERLAGMEGRAVDARKWVNLYSFDVMGALTFGE
GFGCLERGEPHWAIELLDATMRQIGLCVPIWVMLAMNAVPGLSRDWWRFLEFCGQMLRYRVKNKPAIPDVSSALIAHLEG
RDPTPSEELLLDGDARLVVVAGSDTTACTLAAVLYELVRHPEEADKLRAELAPYADASDNGELLHSQIANLDHLNGVINE
ALRLYPPVPGGLQRKTPPEGIMIDDVFIPGDMTVSCPQYVVSRSPLCYEQPDEFIPERWYKRPELIKDKTVFAPFTIGPY
SCIGKPLAMLNLRTTVARLVMEFDVRFAPGDDGRKFLDEAQDNFVLYMGELNVVFERRR*
>CYP5076B1 = old CYP670C1 Phaeosphaeria nodorum SN15
AAGI01000168.1
41% to 670B1, 37% to 670A1 no introns
122339
MRLAHGGTAVVAGITAHLVYFHRGEHFGNGARYLSAFGFGVTILAGVRYTGENAGGYFECLAWALTM 122139
122138
AAYFLLGLYGSTLVYRLIFHPLNRFPGPLAARISDLWLCTQLGGHDMHHLSERLSKRYGE 121959
121958
FVRIGSSTLMLTHPKAVAAIYGPGSPCRKGTFYDLEQPNRGIATRDESLHAGRRR 121794
121793
VWSRGFGDKALRTYEPRVAAYVHMLLGRLADARGKPVDMARLAEAFAFDTMGDLGLGAD 121617
121616
FGMLRQARTHEAVEQLVQGMTIMGRRLPMWLMRLLIDVAQALVPTAATTGFLG 121458
121457
FCHHHLDRFMADPRRSERPSLMAPLLSHYEKQNIADRDLSILRNDCRFIIIAGSDT 121290
121289
VAATLTFAFFYLAKHPGHVTRLREELFPLRAADGTFSHQRIFDAPHLNAVINETLRLHPP 121110
121109
ASTIPRVTPPQGLVVADTFIPGDMTVFSSQYALGRSEAIYSKASDFIPERWCSRPDLIK 120933
120932
DGSAYAPFSIGHHSCLGRPLALMEMRLVLAETLSRFDIAFAPGFDANHFLQHVHDCMSWH 120753
120752
IGKLGLTFTAIE* 120714
>CYP5076C1 = old CYP5066A3 Aspergillus oryzae RIB40
AP007151.1 genomic DNA, SC005
complement(join(1085860..1086053,1086107..1086208,
1086271..1086569,1086625..1086746,1086798..1087521,
1087687..1087712))
locus_tag="AO090005000422"
MDIKEKPTLYAFA
1087673 LGILIHILYFRIGEHHLYPARYIYGYFGSFIGVAAFLYLVEELPVHSASYRSLYL 1087509
1087508
IFTHLLGLYSSLVLYRLLYHPLRHFPGPFLSRVSVFWLSVQLRHKTLYRKLADLHNEYGD 1087329
1087328
FVRVGPSDLSIIHPKAVNTIYGFKSACTKSAWYDSSAPLRSLHSHRNRAAHDKHRRTWTP 1087149
1087148
GFTDRALHGYEKRIQVYRQKLINQIKSMEDSKPLNINTLFTWYGYDVMGDLAFGQSFDM 1086972
1086971
LVKSESHWAILMIHSMLKPMEYLMPIWFFRLLLSIPGTTKAFWKFNEYWGQLFKMRMA (0)1086798
TKQEIPDISACLLEPLKGRAPTPDEFNVLLGDASLIINAG (2) 1086627
1086568
DTTATTLTTIIYELARRPGEVQKLRTELVSCTTDPNGEYTQESLAILKHLNGVINETLRI 1086389
1086388 HSPVPSYIPRKTPPEGINIDGTHVPGNMNVSCPQWVIGR (2) 1086272
1086209 SESVYQNAQNFIPERWYLYPKMIKERSAFAPFTT (1) 1086108
1086054 GPYTCVGKPLALMNIRATIARLITTFDMELPPGDDGRALERSMREHFSI 1085908
YMAKDIQVHFQKRAI*
>CYP5076C1 = old CYP5066A3 Aspergillus flavus NRRL3357
AAIH01000263, AFL2G_00411
99% to CYP5076C1 only 2 aa
diffs
5507
MDIKEKPTLYAFALGILIHILYFRIGEHHLYPARYIYGYFGSFIGVAAFLYLVEELPVHS 5686
5687
ASYRSLYLIFTHLLGLYSSLVLYRLLYHPLRHFPGPFLSRVSVFWLSVQLRHKTLYRKLA 5866
5867
DLHNEYGDFVRVGPSDLSIIHPKAVNTIYGFKSACTKSAWYDSSAPLRSLHSHRNRAAHD 6046
6047
KHRRTWTPGFTDRALHGYEKRIQVYRQKLINQIKSMEDSKPVNINTLFTWYGYDVMGDLA 6226
6227
FGQSFDMLVKSESHWAILMIHSMLKPMEYLMPIWFFRLLLSIPGTTKAFWKFNEYWGQLFKMRMA (0) 6421
6473
TKQEIPDISACLLEPLKGRAPTPDEFNVLLGDASLIINAG
(2)6592
6651
DTTATTLTTIIYELARRPGEVQKLRTELISCTTDPNGEYTQESLAILKH 6797
6798
LNGVINETLRIHSPVPSYIPRKTPPEGINIDGTHVPGNMNVSCPQWVIGR (1) 6946
7010
SESVYQNAQNFIPERWYLYPKMIKERSAFAPFTT (1) 7111
7165
GPYTCVGKPLALMNIRATIARLITTFDMELPPGDDGRALERSMREHFSIYMAKDIQVHFQKRAI* 7359
>CYP5076C2 = old CYP5066A4? = old
CYP5072A1 Aspergillus fumigatus
AAHF01000014
join(762752..763720,763784..763905,763978..764276,
764348..764487), gene model missing last
exon
end of this predicted seq is wrong, replace
with last exon
locus_tag="Afu8g00190" eighth P450
of 8 on this accession
51% to CYP5076C1, 43% to CYP5076A1, 34% to 670A1
MMPSVMKCGYLATAGLIGICTHLSYFRYGEHHLY
PWRYVRFHLCLTMGVAALLYAKKPPQYTLCSMDLVKDVSLLMATYLVGLFASLLLYRT
LFHPLRQIRGPWAAKISSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPE
AVRMIYGPNSRCSKNTFYDNGHPMMSLHSYRDRIAHDQRRRVWSAGFGDRALRGYEQR
MRVYRQKLFQRLEARAVAESAINISQWFNFYSYDTMGDLAFARSFDMLDASRNHWAVD
MLMHGMIGYRYLFPSWFFRLLATMPSLSSDWHKFIGFATDTMLRRVGEQVDVPDIFAS
LLAPLNGREPTEDERNMLMGDAMLIITAGSDTTATSLTSIVYELARHLDEVDKLRAEL
DPIEADSDGEYQHDTLAKLPHLNGFINETLRLHPPIPGVIPRKTPPEGIHVKDVFIPG
NMTVFSPQWSMGRSEAAYIDPEIFNPERWYKHMDLVKDPSAFAPFSI
(1)
GPYSCIGKPLALMNIRTTVARLIMSFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH*
>CYP5076C2 Neosartorya fischeri
92% to 5076C2 Aspergillus fumigatus = ortholog
NFIA_093700
MPSVMKCGYLATAGLIGICIHLWYFRYGEHHLYPWRYVRFHLCLTMGVSALLYAKKPPQYTLSPGDLVKDTCLLMVTYLI
GLFTSLLLYRTLFHPLRQIRGPWAAKVSSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPEAIGIIYGPNSR
CSKNAFYDNGHPMMSLHSYRDRTAHDQRRRVWSAGFGDRALRGYEQRMRVYRQKLFQRLEERADAESTINISQWFNFYSY
DTMGDLAFARSFDMLDASRNHWAVDMLMHGMIGYRYLFPSWFFRLLATMPSLSNDWHKFIGFATDTMLRRLREQVGVPDI
FASLLAPLNGRDPTDDERNMLMGDAMLIITAGSDTTATSLTSIVYELARRPDEVDKLRAEIEPIEADSDGEYQHDTLAKL
PHLNGFINEAFRLHSPIPGVIPRKTPPEGIHVKDIFIPGNMTVFSPQWSMGRSEAAYVDPAIFNPERWYKHIDLVKEKSV
FAPFSIGPYSCIGKPLAMMNIRTTVARLIMRFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH*
>CYP5076C3 Aspergillus niger
fgenesh1_pg.C_scaffold_5000548|Aspni1
57% to CYP5076C1
MSLFRFPLLSLRVLPLLHKICSDSCDMNLENGLQLKAGAFVLGVLAHSVYFRSGEHHLHPVRYLYAYGSLGILVAAILYY
AHNISLTRASTASLSLISTHLLGLYCSLIIYRALLHPLRRFPGPFGARLFGFWLPAKLFHRPLYQVLADLHKYYGPFVRI
GPSDLSIIHPDAVNIIYGFRSACTKAPFYDLGAPVQSLHAHRDKEAHDQRRSVWSLGFSDKSLRAYEKRIQVYRQKLIDL
LTSAGDDEAINISNYLTWYSYDVMGDLAFGRTFGMLDASANHWAIQILNDMLKPLEYSVPIWALRLLGSLPGMNEDALRY
EEFSHRRLKRRMGEKPEIPDISSSLLEELQGRDPTTKEYYQLLGDVELIIAAGSDTTAAALITVIYELAKHPVHVDIIRE
ELSLCAVEPSGEYMHEKIAGLSHLNGFINEVLRLHPPIGSIIPRKTPSEGITIGDTYIPGNMTVSCPQWVIGRSDLFYEN
AHQLLPERWYKYPEAMKHKSAYAPFSVGPYACIGKPLALINMRTTVARIIMAFDLQLPLDDVGTLLDKNMKEHFSSYVEG
IYIIFRKRSRNFQTD*
>CYP5076D1 Aspergillus fumigatus Af293
GenEMBL XP_751878.1
52% to
CYP5076A1An, 48% to 5076C1, 46% to 5076C2, 42% to 5076B1
note: duplication of KLR seq is missing in
Neosartorya fischeri
MDSYVLIAIAGVLSHVVYFRRGEHQLYSHIYLVLFVISAAVVTVLVHYSYILVYLASLYTSILVYRLLLH
PLRSFPGPLAARVSGLWYIHPKHNAYLSLQALHSQYGPIVRTGPSDLSIIYPSAVPAIYGAQSACTKGPW
YDLSYPSRPLQHCRNAKEHHARRRTWTPAFSDRMVRGYEQRIQTYQQQLIAQLTARQTVDIRKWIYLYTF
DVMGDLSFGRSFDCLAAGHEHPGITLLNAALRNIGLFLPPWLHLILLKIPWLTRDWWAFQSFCSERLHAR
MRMDLPIPDISASLLAPLHGRAPTPEERLMLDGDARLIVVGGSDTTAVSLCGALYELARHPEQLRKLRKL
REEVEPFVDAAGDVRGADIALLEHLNGVINEALRMYPAVSSGLQRKTPPEGIQVEGVHIPGEMTVYCPQY
VLGRSELCYARPDEFIPERWYKYPGLIKDRSAFAPFSLGPYSCVGRPLALLNMRTTIAKLVTTFDMGFAP
GEDGKAFKQQAQDNFVLYMGPLHLTFARREGNWRRRSDG
>CYP5076D1 Neosartorya fischeri
93% to CYP5076D1 Aspergillus fumigatus = ortholog
NFIA_106550
MDPYVLIAIAGVLSHVVYFRRGEHQLYSHIYLVLFVISTAVVTVLFHYSYILVYLASLYTSILVYRLLLHPLRSFPGPLA
ARVSGLWYINPKHNAYLTLQALHSQYGPIVRTGPSDLSIIYPSAAPAIYGSQSPCTKGPWYDLSYPSRPLQHCRNAKEHH
ARRRTWTPAFSDKMVRGYEQRIKTYQQQLIAQLTTLQTVDIRKWIYLYTFDVMGDLSFGRSFDCLTTGHEHPGITLLNAA
LSNIGLFIPPWLHLILLKIPWLTRDWWAFLSFCSERLQARMRMHLQIPDISASLLAPLKGREPTPEEKLMLDGDARLIVV
GGSDTTAVSLCGVLYELARHPEQLRKLREEVEPFVDDAGDVRGADIALLEHLNGVINEALRMYPAVSSGLQRKTPPEGIQ
VEGVHIPGEMTVYCPQYAMGRSELCYARPDEFIPERWYKYPDLIKDRSAFAPFSLGPYSCVGRPLALLNMRTTIAKLITT
FDMGFAPGEDGKAFKQQAQDNFVLYMGPLHLTFTRRK*
>CYP5076D2 Aspergillus clavatus
61% to 5076D1
AAKD03000015.1
ACLA_048760
MYSSILTIAGILSHLLYFRHGDHHLLGVTYLQLFVFAVASTTLYYQYIHDLPWSSALTTTSHIFFRYLAGLYSSLLVYRF
FLHPLRRFPGPRAARLSGFWSFTPKHTNHTTLLALHRQYGPIVRAGPAELSLILPSAVPAIYGNQSACVKDSVYDLVLPS
QPLQNCRDRAEHAARRRIWSPAFSDKRLRGYEQRIRVYRQQLVDQLHHLADTPVNICKWFNLYSFDVMGDLAFGRGFDSL
ATGHEHWAILLLVEGMKQVGLFFPPWAAQLLLAIPGASKGWWRLLDFCSERLDQRIREGERVDAETDTYFPDISESLLAP
YKERAPTLQERRDLDGDVRLIVVAGSDTTAVTLSSIFYELVRHPGEMAKLRAELAPYATGADDGEFLGSQIAHLDHLNGV
INEALRLYPPVPGLLARRTPKEGIVVDGVYIPGNMTVSCPQYVMGRSELCYERADEFIPERWYKSPELIKDERAFAPFTI
GPYSCIGRPLALMNLRATVARLVITFDVEFAPGEDGRAFVEKAQDNFVLYPGALNLTFKKR*
>CYP5076E1 Aspergillus niger
fgenesh1_pm.C_scaffold_3000040|Aspni1
44% to CYP5076C2
MILGSHLMLFAAGALSYHLFFKHEEHHLRIVRYIQVLAATFLGMVVCFQHGYRLDFSSSLTQAARIQGSFLSGYYTSILI
YRMFFHHLNFFFSVIFRHSDGFRQVQRLHDQYGPFVRLRPNYLSIAHPKAVNVIYGLGSRCMKADWYDISCPMVSLQTLR
DRKAHDERRRVWSAAFGDKAVRGYEQRLLPYLNHLMAYFSSQAVANKPVNVIKWFELYSYDFMGNLTFGKSFGMLEAHQD
HWAIDSLKKVMIPLGFAFPTWFFRVVISIPGLSRAWQRLFDFCGQRMLERIKTPAEIPDIASVLVAPLKGQQPSQEQWEL
LRGDAQLVVLAGGDTTATTLSAAVYQLVQHPEQVQRLRDEVSPYIAGPSHEVLHEKIANLPHLNAIINETLRLHPPAATA
LQRKTPPEGIIVDGVHIPGNMTVMCPQNVLGRSEAVYERPMEFLPERWYLQPELVKDKSAFVPFSIGPYGCIGKPLALLT
IRNTLVRLVTMFNFEYAHGEDGMAFEGKAKDRFTMSFGDLQILFSERSDM*
>CYP5076F1 Aspergillus terreus
49% to CYP5076C1
ATEG_06378.1
MWIQKNIEAIAFISGVVTHIFYFRKGEHHLYPFSYLYTYVGLSLTGAALLHYDAEASVIEATRQSI
SLICIHLLGLYTSLLVYRLFLHPLRRFPGPFGARISGFWMPMKIRYQPPYQILEDLHRKY
GDFVRIGPSDISVTNPKAITAIYGLKSRCIKGPLYDFNYPVLSMQT
MRSKEDHHQRRRIWNPGFTESAVRGYEKRVRPYRQQFMSHIASASDDGKPLDISEVCQWYSYDVISDLALGKSYGGLQKG
VRVPIAQSFIDANTGLRNMYPPWFYRLIVTSPMGSQEWKEFNDRIWQDLMARMKVTFFDLSEPDVPDIYSYFLAPLKGQQ
PTPDDIPRLLGDALLLIGAGGGMTLTVAIYELARRPEEVKKLRDELACCPRELGGEYAHENIASLRHLNGFINEVQRMHA
GVPSQLPRKTPPEGLDIDGTYVPGDMNILSPHREIGRSEAAFEKPQEFIPERWYLYPNMVKDKSAHAPFSTGSYGCIGKP
LALMNLRTTLAQLVMTYELELAPGDDGFALERNMDELFSIYVHNLYVVFREREL*
>CYP5077A1 Aspergillus nidulans AN6449.1
42% to 532A2 cyan too long 53 clan
MAILVRLFFALFVVSVYFFRVRLRLSHIPGPFLASLTNINRRQWVTTGRA
HTIHTELHRQYGKVVRAGPNTVFVSDPAAIPAIYRFNEPYQK (0)
SEFYDALMPYVRGKSIPDVFATRDEHIHRTMKQPIAAIYSMSNL
VSFEPYVKSTIEYFFSRLDSLFVETGKVCNFGLWLHLFASDVMGEITFSR
RLGFLETGGDMENVMANNWKFFVQAAPATQMPWLDYFWKRNPLLPGSVKP
NKVIEFGVARIQERLHL
SEKHPDHVNSRDFLSRFIAAKEKNSQIGPDAIM
TWANSNIQAGSDTTAILLSALFYHLLKNPTSLAALCTEIDAAAKRGCLSS
ILTWKETRDLPYLDACVKEAARLHPPISLPLERVIPESGTVIGGFKIPGG
TRVAMNPWAVHRDRDVFGADADTWRPERWLEGEEKAKTLYNSLLTFGGGH
RSCLGKNISYLEIYKLVPSILLRYEIGLAEPEKEWHLENRCCWTKLGTIR
LVSRFLG
>CYP5077A2 Coccidioides immitis
56% to CYP5077A1 Aspergillus nidulans
CIMG_04681.2
MDHSLFSEFAGRAAKWSGSFAIAAVIFIVFHS
MVSYFKLRHIPGPPIAAFTNVVRRAWVGRGDLHEKHTRLHRKYGTVVRVGPRAVLISQPKAIEKIYGFKAKFLKSEFYDS
IIPRIKGGKIPDVFATRDEDLHRQMRKPIANLYSIANLISFEPLVFSTMRCFFSRLDELFTDKNKDFDLGQWLQLFTFDV
MGEVTFSRRLGFLEKGGDIENVMENNWQYFQAAAPMPWLDYFWKDNPLLPTVSKRNPLADFGAARIKERLDMTEKERSSI
NQRDFLSCFIEEAHKNPGLPKLALPTWTNSNIQAGGDTTAIMASVILYYLLKNPSTLDVLQREIDKAAHEGRISEFVTWK
ESQTLPYLDACVKEASRLHPPIGFPLERIVPESGLQVDGYHIPPGTRVSMNPWAVHREISLYGDGAEIWKPERWMCSEME
KKAMYHSLLTFGAGHRVCLGKNLSYFEVYKLVPSLLQKYQLELVDPQREWSLETKWFTMPSGFRVRIKSRNSTKRNPDNP
NIG
>CYP5077B1 Aspergillus terreus
49% to CYP5077A1
ATEG_03631.1
MALLEDIINFATLNPMVVVAIPVFLFVISLLRSYLRLAHIPGPFAAGWTNLPRFSWVLSFKAHDIHTALHRKYGPLVRFG
PNMVSVGDPKEVGHIYGFTDPWMKSDFYHALLMKPRGKPIPGIFAAQDENIHRALKKPISSAYSMSTLLSFEPYVDSTMR
VFCEQLESRFIENKKPLDFGKWLQMFAFDVIGELTFSRRLGFLESGEDINHVMANIWETFKKTSLVTQMPWLDKLWTNNP
IQRWRRGGGASPGAAFAMARVEERRELQRTTNKNDWHFNTRDFLSRFMEAEAKDPSIPPYALAAWASSNITAGSDTTGIF
LRTIFYQLLTHPETLRKLREELDQAAAAGNLDDLASWKQTRELPYLDAVIKEGGRIHPPFGLPYERVVPAQGATICGKFL
PGGTLVGMSAWVVHRNKELYGEDCDEWNPDRWLKCDTEKRRKMENALLT (0)
FGAGHRTCMGKHIAYLEMYKVVPTLLRKYD (0)
FDLVGQDEGGGWTVLNRWFVMQEGFLVRLKKRAK*
>CYP5078A1 old name =
CYP532C3 Nectria haematococca
fgenesh1_pg.scaffold_24000135
Necha1/scaffold_24:345480-347594
57% to 532C1, VIGNVDEDSK might be a small intron, N-term too long
exon 1 probably not real, can extend exon 2 to
a good start MET
MSQFPQLRTNKSCRYPSLTETFPVNSREIRRRSPHSRCRYRFWGANRCNGIVIIPVQRELPASCGGCYSA
PWANAPRLMDHRGSLRWLP (1)
MATTSEMIRTFVQFLTPLNLSFLA
VTVFILHSIRNKFRRGLRTLPGPTLAAYSGVWRYLDVRSGQAHKTAINLH
RKHGSLVRIGPNHVSISDPREIKKIYGLKSGYTK (1)
TAFYPIQSITWKGKVEVNLFGTRDEDYHRELKKPVA
NAFSLSTLLTNEPAVDSCTNLLIEKLSQYADASAPVDFGEWLQFYTFDVVGEITFAKKLGFLEKGGDVDG
MIQAIEDLL (0)
VYASSIGQVPVWHNFLMGNPLLPILFPSMEGWNKVLTFTLKAVNAVIGNVDEDSKLKKDGE
FNIESLDKQGDMLSKWFAVKLANPEKMSTRDIVVHLSTNVFAGSDTTAIALRAVFYNLLKSPAKMQKLVK
EIDDAAAAGLLSSPISFKDSTKNLPYMQAVLKEGLRIHPSVGLLLERHVPAGGAVICGKPIPEGTIVGIN
AWVTQHDPEVFPNPDQFEPERWLDASEEQLKMMEQSFFAFGGGSRTCIGRHIAIMEMAKLIPEILRRFEL
SLPSPDHEWHTKNIWFVQQEGLICNLKRRQQA*
>CYP5078A2 Fusarium graminearum FG08008.1
AACM01000323 FGcontig1.323_scaffold5
MSHQYVAAAASAFLQFKY
HLVTFFFGLIILSYVHGRFRSGLANIPGPPVAKWTKLWRLYDVYKGQSHH
TAIRLHQQHGPLVRIAPNVVSVGDPQAIKTIYGLAGAFTK (0)
TAFYPIQSIS
WQKKPQMNLFSTRDPVYHRDQKKKVAGAFSLTNLLESEDAIDSCTELFIS
RLDQWAADGKRIDLGMWLQYYAFDVVGEVNFAQKLGFLATGGDVDGMIKT
IEGIIAYSSICGQIPEMHNVLLGNPLF
PILLPSMENWNAVLTFTLKAINS
RTSMKRDGELELPDEGGKDLLSKWAAVKNKDPLKMSTRDAIVHLSANVFA
GSDTTAIALRAVIYFLIKNPDKMTNVVQEIDAADKNGNLSDLISYKESTS
HLIYTKAAIKEAMRLHPSIGLLMERHVPPQGAEICGHFFPGGTIVGINPW
VVQHDPKVYEDPEAFKPERWLTSDAELL
SKMEASFFTFGAGSRTCLGKHI
SLMELHKVVPQLLRRYHIVLADPDADWEVKNRWFVQQHGLNCILKKRTVA*
>CYP5078A3 Aspergillus nidulans
AACD01000128 AN7359.1 62% to 523C1 53 clan
MPTTLSTLQSSLPLPLPVLAIIALFLLRFIWRRFGSGLRGIPGPALAKCT
RLWKLHSVWKGDHHLTEINLHRQHGPLVRIGPRHVSVADPKAIPVIYGLN
KGFTKTGFYPIQCISWNKKPQMNLFSTRDEQFHRDQKRPVANAYSMTSLL
ELEPAVDSCTAIFLSRLRDFAGKKRPVDLGTWLQYYAFDVVGEFTFAKKL
GFLEEGRDVDDMMAGIQGILAYASLIGQVPEAHKVLLGNPLMPILMPSME
SWNQVLQFTLKQVNSRTSLARDGELDKGDLEEGKDMLSRWMAIHVADPEK
MSTRDVIVHLSTNVFAGSDTTAIALRAIMYFLLKNPDKMEKAVGEIEAAD
SAGRLSSPISYKESMTHLPYLGAAIKEAMRLHPSVGLILERHVPEGGVTV
CGRYIPAGTTVGINAWALHHDEKVFPSPGAFMPERWLESPPAKLKEMEQS
FFAFGAGSRTCVGKNISLIEMHKIIPQLLRDFTFRLHRPGDEWKTKNAWF
VQQEGLVVDLERRR*
>CYP5078A4 Aspergillus fumigatus Af293
GenEMBL XP_748665.1 also EAL86627.1
72% to
5078A3
revised 3/12/2009
MEVSILSLFKAYAAYVTVAVVLLRLITNRFRRGLAGIPGPTIAKWTRLWKLHSVWKGNHHTTAIDLHRKY
GPLVRIGPKHVSVGDPSAIPIIYGLNKGFTK (0)
TGFYPIQCISWNKRPQMNLFSTRDEMFHREQKRPVANAYSMTSLLELEPAVDSCT
EIFINQLARFANSKKPVDLGMWLQYYAFDVVGEFTFAKKLGFLQEGKDVDGMIEAIQGMLVYASVCGQIP
EAHPLLLGNPLFPIFMPSMETWNQVLNFTLKAINSRASLQRDGELDAEKPEAGKDMLSRWMAIHLSDPEK
LTTRDVIVHLSTNVFAGSDTTAIALRAVFYFLLRNPSVLAKLNAEIDNADREGKLSTPISYRETMNHLPY
LQ
AVLKESMRLHPSVGLILEREVPKGGVTICDRHFPGGTIVGINAWVLHRDARVFPDPDKFIPER WIDSD
PQHLKKMDQSFFAFGAGSRTCIGKNISLIEMHKIIPQLLREFEIRLHSPEKEWKTKNVWFVQQEGLVCDL
VCRRDAKCYH
>CYP5078A4 Neosartorya fischeri
NRRL 181
DS027697, NFIA_005630
complement(join(1475691..1476929,1476977..1477279))
93% to
CYP5078A4 = ortholog, 75% to 5078A1
note
name changed from CYP5078A6
MEVSILSSFKAYAAYVVIAVVVLRLITNRFRRSLAGIPGPAIAK
WTRLWKLHSVWKGDHHTTAIDLHRKYGPLVRIGPKHVSVGDPSAIPIIYGLNKGFTKT
GFYPIQCISWNKKPQMNLFSTRDEMFHREQKRPVANAYSMTSLLELESAVDSCTEIFI
NQLARFANSKKSVDLGMWLQYYAFDVVGEFTFAKKLGFLQEGKDVDGMIEAIQGMLVY
ASVCGQIPEAHPLLLGNPLFPIFMPSMETWNQVLNFTLKAINSRASLQRDGELDAEKP
EAGKDMLSRWMAIHVSDPEKLTTRDVIVHLSTNVFAGSDTTAIALRAVFYLLLRNPSV
LAKLNAEIDNADREGKLSHPISYRESMNHLPYLQAVLKEAMRLHPSVGLILEREVPKG
GVTICDRHFPDGTIVGINAWVLHRDARVFPDPDKFIPERWIDSDPQHLKKMEQSFFAF
GAGSRTCIGKNISLIEMHKIIPQLLREFEIRLHSPEKEWKTKNVWFVQQEGLVCDLVR
RRDVK
>CYP5078A5 Aspergillus oryzae
GenEMBL BAE65602.1
66% to
CYP5078A3
MIDAASVVILIIGLIVARLVTNRFRLSGIPGPSLAAYTRLWKLYNAWKGDHHHTEIALHRKYGSLVRIGP
RHISVSDPKAIPIIYGVNKGFTKTAFYPIQSISWDKKPQMNLFSTRDELFHRDRKRPIASAYSMTSILEM
EPAVDSYTELFLSQIRKMVEEKAPIDLGMWLQYYAFDVVGELSFAQKLGFLEKGEDVDNMIEAIRGMLTY
AMICGQIPEAHKVLLGNPLFPILLPQMETWDQVVVFTLKAINRRASLQRDGDLGKDEIDEAIGGKDMMSR
WLAIHNADPTRLSTRDLMVHLSANVFAGSDTTAIALRSILYHLICHPDKMAKVRAEIDTADQEGKLSNPI
SYQESNTHLPYFGAVMKEAMRLHPSVGGNLERHVPPQGVTICGHYIPGGTNVGINPWVVHRDPIVFPQPD
SFIPERWLDSTPEQLKEMEKAFLNFGAGSRSCIGKAISLMEMRKILPQLLREFDIHLHQNKSWKTRNVWF
VQQEEFICDLTPRVRS
>CYP5078A5 Aspergillus flavus
99% to CYP5078A5 Aspergillus oryzae
AFL2G_12240
MIDAASVVILIIGLIVARLVTNRFRLSGIPGPSLAAYTRLWKLYNAWKGDHHHTEIALHRKYGSLVRIGPRHISVSDPKA
IPIIYGVNKGFTKTAFYPIQSISWDKKPQMNLFSTRDELFHRDRKRPIASAYSMTSILEMEPAVDSCTELFLSQIRKMVE
EKAPIDLGMWLQYYAFDVVGELSFAQKLGFLEKGEDVDNMIEAIRGMLTYAMICGQIPEAHKVLLGNPLFPILLPQMETW
NQVVVFTLKAINRRASLQRDGDLGKDEIDEAIGGKDMMSRWLAIHNADPTRLSTRDLMVHLSANVFAGSDTTAIALRSIL
YHLICHPDKMAKVRAEIDTADQEGKLSNPISYQESNTHLPYFGAVMKEAMRLHPSVGGNLERHVPPQGVTICGHYIPGGT
NVGINPWVVHRDPIVFPQPDSFIPERWLDSTPEQLKEMEKAFLNFGAGSRSCIGKAISLMEMRKILPQLLREFDIHLHQN
KSWKTRNVWFVQQEEFICDLTPRVRS*
>CYP5078A6P Aspergillus clavatus
pseudogene 74-85% to CYP5078A4
ACLA_060970
AAKD03000012.1
VH*PFFPSLRLMPHISLGDPSVIPIIYSLNKGLQRY ()
MNLFSARDEIFHREQK ()
TFDVVRELTFAKKLEFLEEARDMDGIIEAIQGMLTYTSLCGQVPEAHP
()
162515
RDVIVHLSTN
162490
AVHASDPEKRRHCSSFNEFLAGSDTDAIALWAVFYLLLQNPTGMTKLLVEIDDA 162651
162652
DRNGRLSNSISYRETTTHLPY
IQAVLKEPMRLHPSIGLILEREVPKGGVTICDKHILSGTIVGINAWVLHRDARVYPDPDSFVPER
*IDSDPQ*LKKMEHSFFTFGSGSRTCIGKNISLIEMHKIIP
QLLREFETRLHSPEKEWATRNVWFVQQEGLICDLVRRRDRQ
163153
>CYP5078A7 Mgr049 Mycosphaerella graminicola
64% to CYP5078A2 Fusarium graminearum
MAHLASYLLPILFLLFLLSFVHAKFNGLNKIPGPTIASFTKLWRLYDVWQGQAHWTAIKLHRKYGKLVRIAPNVVSVGDPDEIQRIYNIKGNFTKTAFYPIQSISWQKKPQPNLFSERNEAEHREQRRKVANAYTLESLLKMEPAIDECTKLFLSKMGEYADRDEPVDLGQWLQYYAFDVVGELTFAKKLGFLEKGGDVDGMIEAIEGMLVYASHCGQVPEMHPWLLGNPLFSIMLPAMETWNGVLMFTLKAINSRTTLSRDGELELENRVGNDFLSKWAAVKAFDPLKMSTRDVVVHLSGNVFAGSDTTAIALRAILYFLMKHPDKLRKLQREIDDAHNAGKLSDPISDKEARDLPYLNAVEKEAMRLHSSVGLILERHVPAEGATICGELIPGGTIVGINPWVLQYDPEVFPDPEAFVPERWIDSSPDRLAAMDKSFFTFGAGSRACLGRYISMIEMRKVIPQLLREFDISLQGDEEWKVKNVWFTQQD
>CYP5078A8 Fusarium verticillioides
77% to CYP5078A2 Fusarium graminearum
FVEG_03329 not found in the F. oxysporum
genome
MLSVNLSIVKATIFSLQS
HFVGSFFLLLALSYVYDRYRPGLSCIPGPPLAKWTKLWRLYDVYNG
QSHQTAIRLHKKHGPLVRIAPNIISVGDPAAIKTIYGLTGAFTK
(0)
SAFYPIQSISWNKKPQMNLFSTRDTVYHREQKKKVAHAYSLTSLLGSEEAMDSCTELFTSRLD
EWATTDKPIDLGAWLQYYAFDVVGEVTFAQKLGFLETSADVDGMMETIEGILF
YAALCGQVPEMHPFLLGNPLFPYLIPAMESWNAVLTFTLKAINSRTTIQRDGE
LELNGDGGRDFLSKWAAVKKRDPLKMSTRDVITHLSTNVFAGSDTTA
IALRAIVYFLIKHPEKMRMVVEEIDTADKSGKLSDPISYKESTGHLP
YMGAVIKEAMRLHPSVGLLMERHVPPQGAEICGQFIPGGTVVGINPWVLHSDP
SVYKDPKSFIPERWLTADAGLLSKMEHSFLTFGAGSRTCIGKYISLME
MHKVVPQLLRRYTIKLEDPKAEWRTSNRWFVQQHGLICTLKKRT*
>CYP5078A9 Aspergillus terreus
73% to 5078A4
ATEG_01078.1 model is a fusion with two other
genes, revised
MISKATLALLLLSVYLLRLITNRFKSGLRDIPGPTLAKYTRLWKLYSVWKGNHHTTEISLHRKYGPLVRI
GPNHISVGDPAAIPIIYGLNQGFTKTGFYPIQSISWDKKPQMNLFSTRDEAFHRSQKRPVANAYSMTSLLEMEDAIDSCT
HLFMDRLRAFAAHKRPVDLGTWLQYYAFDVIGEVTFAKKLGFLEEGRDVDAMMESIQGILRYASLCGQVPDAHPFLLGNP
LFPIFVPSMESWNQVLQFTLKVLHARGSLGKDEENMHEQSPDEGKDQLSRWLAIHRSDPAKLSKRDIIVHTSTNVFAGSD
TTAIALRAIFYFLLRHPSVLAKAQKEIDAANAQGQFSDPISYRESVTHLPYLAAVFKEAMRLHPSVGLILERHVPRQGAS
IAGKHIPGGTVVGINAWVLHHNPAVYPNPEAFVPERWLDSSPAALKAMEQSFFAFGAGARTCIGKNISLMEMHKIVPQIL
REFDVRLCAPELEWKTRNVWFVQQEGLVCELVPRRH*
>CYP5078B1 Mgr078 Mycosphaerella graminicola
46% to CYP5078A4 Aspergillus fumigatus
N-term from JGI model e_gw1.1.657.1|Mycgr3
cyan region is too short compared to CYP5078B2
MALPALLSNSDTSSVRTLSLALLGLLISSIGY
LLHVKFRPGLRRIPGPWLASISSLDRLRSAASGQQMNYHLKLHEQYGPLVRIGPNHVSFAYADLIPDVYGVGTKFRKVSLLLWSHEVAHRDMRRPAANAYSMSSLRELEPMNDACSAVIVEKFNKYVDKEIDLGTWLQWYAFDVVTSITFSNTLGMLEQERDVDNVIEAIEAGLAYNSVIGQVPWLHKLLFGNPMVVKVANLVPSIRKMSNSFELMSAFLKRQVKRYENEEFNTIPLQDMLSRFKRVKDGKLLMSDDLVLSHTGSNIFAGSDTTAISLRSVFYNLCRNKQAHDKLLAEIDEADRNGLLSNPVSFAEAQRLPYFQAVMKEALRLHPAVGQLLERRVPKGGADIGGAWLPEGTIVGMNPWVSARDGSVYGLDHDDFRPERWLEASETQLRLMDRNDLSFGAGARTCLGKNISILEMSKLIPELYRHFDFELTDPTKEWELHDYWFVKQTGLICKVKRRERSC
>CYP5078B2 FD670996
Mycosphaerella fijiensis MfEST3 53% to CYP5078A1
63% to CYP5078B1 Mycosphaerella graminicola
C-term is from EST, this region is gapped in the genomic seq.
estExt_Genewise1.C_12420
MLEPIADAAIWQLILFGAIACTIAYYASIRYRPGLRKLPGPFLASISDLDRIWSCAKGLQMQYHIALHRRYGPFVRVGPN
HVMFSDASLIPRVYGIASKFWKSDFYVPFDVKTPKGILPTVFSSRDEYEHRDMRRPIAHAYALSTLKELEPMNDACSEVL
LRKFDGMVGKEVDLGTWVHWYAFDVITSITYSNTLGMMEQERDIERIIESIEGRLVYNSVIGQAPYLHKYLFGNPYVSKM
ANLIPAIAVMNTSKYIVAFAAKQVQRYYSDEPKTFELKDMLSRFKRFKDEEQLIDDSLMISHSAGNIFAGSDTTAASLRS
IFYQLCKHKTAHEKLLSEIDAADRMGKLSDPVTFAEAQELPYFQAVVREALRLHPAVGLLLERVVPKGGAEIGGVFLPEG
TIVGANPWVMARDPSVYGEDADVFRPERWLEADAQRLKLMERNDLSFGGGARTCLGKNISVLEISKLVPQLLRKFDFELA
NPDQEWTLHDYWFVKQTGLICRIKRRQGTDTA*
>CYP5078C1 Histoplasma capsulatum G217B
44% to CYP5078A3, 41% to CYP5078B1
HCB01854.1
MASGISAFALNLQFDNLHTYSILVAFFFFVSCIWTRYSPGLRNVPGPFVASFSNLWKIYRVLKKDMAWRNIEVHEKYGPL
VRIGPNHVSASDPEALKTIYNFTNIFPKSEFYSIGEGLYEGKKLPTLFTTRSNEYHARLKRASAKGFSMTALSELEPYVN
GCIELFLKRVEERSNDGKIALDIGPWMQFFAFDVLGEVNFSKSLGFLETGVDVDNNIAAIDQFLSYVSLIGQIPTAHYFL
LGNPILPLIFSNYEKLNKIQEFAIAMVKERRQNPVDRKDILASLFEVHDSSPSKLSSREIVAITTTNIL
AGSDTTAITLR
AVFYYLCKNPSTYRKLQREVDSAVEEGRLSKPATYKETTTLTYLGAVINEAMRIHPPTGFILERVVPEGGLTLGGTYLPK
GTVVGVNSWVINYNKQVFGMDVGVFRPERWLEGDPEELADRNRNMF
AFGAGPRVCIGKHISLLEMRKLVTEFVRHFNFEL
EDPKAELNIQAGWFVKQEGLKLKFKRRA
>CYP5078C2 Aspergillus terreus
57% to CYP5078C1
Histoplasma capsulatum
ATEG_08443.1
MSSPPAKSILADTVVCVWQQIQLHPWWTALTILLTRLVLTRYRDGLRQVPGPFVASFSNLWKLRAVWKKNMHRENVRVHE
DYGPIVRIGPNHVSVADAPSMRAIYGVQNSAFYPLAEAIYKGRFLPTLFTTESNDYHMRLKRGAVKAFSMDTVVGLEPYV
DKCIAVLVSRLREVTDNGKRPVNPVAWLQYFAFDVLGEINFSKDLGFLEKGVDVDNIIAAIGGILTYVSLIGQIPLAHKF
LLGNPLLPKLFPAIEKTNQVLQFSLAQIEERLKNPVDRKDILSQLLETHRADPDSLTLDEIIAITTTNV
(2)
IAGSDTTAISLSSVLYYLSKYPDTRRKLEK
DIQAAIAEGRASNPITYAEAIKLPYL (2)
TAVINEAMRIHPATGFILERRAPPGGITLHGVHLPEDTIVGVNS
WAIHRNKSIFGEDVHTFRPERWIEGDEEAIKEMKRNLFT (0)
FGYGPRSCIGKNISILEMWKVVFELYRHFDIDLAGDQEWTVN
GTWFTTQSNIEVRFKPKGSTG*
>CYP5078D1P Mycosphaerella fijiensis
47% to CYP5078B2 Mycosphaerella fijiensis
gw1.2.1437.1
TEIDTAGLSDAVTWKEAKAMPYLQACIKEGLRIHPVVAVPLEQVVPKGGLTLSGTYFPAGTIIGCSPFVVARDEKLFPHPDTFRPER
WLEASGQNLLAMERGSLAWGSGKRVCIGKNVAMLEMSKLIPQLLRRYSLEL
ERNVDRTSSVKSWFTWIQDFDVVVKKREAPR*
>CYP5079A1 # is the same as CYP5028A1
no sequence
>CYP5080A1 Fusarium graminearum FG03260.1
AACM01000150 FGcontig1.150_scaffold2
MAIPTSTLLAPAIIIFLILHVLLRALFSPFRTVPGPFLARFTDAWYFWNI
RKGSFQQVNIDLHKKYGPIVRYGPNRYSINDPEAAKTIYGLGNHFPKSSW
YSAWASPGQWXXXXAIFSDQSIERSTQNRKMYSATYAMSAQVHYEHFVDECTEL
FTQRLSELSTSDSNLFVDMRHWFQCYAFDVIGLITYAKRIGFLDRGEDVR
GVIEALEDHMGYATLCGIFPSLHQFLFPLRNYLAGSKGAGRAYVVSFTNXXXXE
RIRESQTSPKPVAAENEVTTQDFLTKFLAKNLADPQNFTQHHVLMGCTSN
MVAGSDTTAISLSALFYHLIKNPSCMEKLRNEIDQLTSRGELSKAPTFKE
SQQMTYLQAVIKETLRIHPATGLPLERVVPEGGATIAGRFFPENTIVGVN
SWVAHRNKNVFGEDAEVFNPDRWLTQDTARLSAMNRYYMPASILYHNFGL
GSRTCIGRHVSQLEMSKLVPRLIRDFNFELDPSLPGGNWSTWNYWFVKPV
DFKVGISLREPKVYA*
>CYP5080A2 old name =
CYP532B4 Nectria haematococca
fgenesh1_pg.scaffold_7000447
Necha1/scaffold_7:1257355-1258984
75% to 532B1, 52% to e_gw1.1.1091.1
length of the gene is better conserved without
removal of the first intron
in this model, missing C-term, wrong last exon
note: 532B1 probably has a gc boundary after
RYYMP. This will shorten 532B1.
MESSISIYVLSVLFIAFLVRFLVQFIRSPLRTVPGPFLARFTDGWYFWNVRKGSFQDVNVELHKKY
(1)
GTIVRYGPNRYSFNDPE
AAKIIYGLGNHFPKSSWYSSWASPGQWAIFSDQSIKRHAQNRRLYQATYAMSSLVHYEPFVDECSDLFTQ
RLAEMSRSNMLVDMRHWFQCYAFDVIGLITYAKRLGFLDRGDDIRGVISALEEHLGYATLVGIFPSLHRY
LFPLKNYLAGAKGAGRAYVLSFTNERIREAQVTPKPVAEESAVTMEDFLTKFLAKHAADPDVFTSFHVLA
GCTSNMVAGSDTTAISLSAVLYYLLKHPACLQKLRDEIDGLTAKGGLSKSPTFKESQQLPYLQAVIKEAL
RMHPATGLPLERVVPEGGATISGRFFPEG (0)
TTVGINTWVAHRDHRVFGDDAETFNPDRWLVDDAARLSIMNRYYMP
(0)
FGLGSRTCIGRHVSMLEMSKLIPRIVRDFD
FGLDPSLQREKWHTQNYWFVKPLDFKVRVEMRQ A
EKSDMF *
VRAPTTCIDDPSDISHSSDWALEHALGDMFRCLKCPSSSPELFETLTLGLIHRYSGRSGTRKTTGS*
>CYP5080A3 old name =
CYP532B5 Nectria haematococca
fgenesh1_pg.scaffold_234000002 short at 55aa
gap near C-term
Necha1/scaffold_234:7436-8694
59% to fgenesh1_pg.scaffold_7000447, 54% to
532B1
end
from fgenesh1_pg.scaffold_28000192 (this
model has a stop codon for Q at RRLYQ
MHPYLLLLAPALLLAVQLLIRLYQILASPLASVPGPWLARFTDLWYAWRINRGQFERDNIALHQKH
(1)
GPIVRYGPKRYSICDPLAAKVIYGHGGAFLKSSWYDSWGNPNPHNWSIFSDRDEKRHSANRRLYQNMYSMSSLV
NYEHYVDECTRLFLQRLSEMSGRQGTAEPVDMGHWFQCYAFDVIGMITYSKRLGFLDHGQDVGDIIKNLE
NHLYYATEIGVYPSLHQYLAPIRNRLGKRGTGRHYIVEFTKQCLADHQSNPKAIISDDLDSASEYHGTMD
FLSKFIAKNTADNSSFTQYHVLAGCVANMVAGSDTTAISLSAILYHLLRNPDKLRILREEIEGFFSNKTG
PATSINFQDSLGLPYLQAVIKEALRMHPATGLPIERVVPKGGAAISGKFFPEG
(0)
TIVGINSWVEHYNPAIFGQDANSFRPERW
LTTDADQLSKMSRHWMP (0)
FGLGSRTCIGRHISTLEISKMIPRLLHEFDFELRGDKPWVTKNCWFVKPVGFQVYVSARVDY*
>CYP5080A4 Fusarium graminearum FG07977.1
AACM01000323 FGcontig1.323_scaffold5
MPFLNWISIWAIGIVAYLLAFFIRLGRSPLRQVPGPFVARFTDAWYLYRT
WKGHFEQDNLALHRQHGPIVRYGVNRYSIDDPLASKTIYGPGSKFAKSTW
YDAWTAPDSPWNLFSDRSIKHHSEARRQYQSTYAMSALIGYESYVDECAE
LFSCRLAELSQGGTSVNIAHWLQCYAFDVIASITYSKRLGFLDQGEDIAG
LMQTLKSSISFATLVGIYSRWHPILFRLVSLVPGSGSNGFLHVERFTRSC
INDCKANPRAVHDDHEKSSDNGISFLHKFLDKHQKDPEKFTQYHIFSGCT
ANMAAGSDTTAISLSSILYFLLKNPQSMKKLRDEIDSKQKEGKLSECPTF
KESPDMPYFQVVIKEALRMHPATGLPLERVVPEGGADLCGQHFPQG
TIIGVNSWVQHRNVGIFGPDADTFNPERWL
TDDPAKLSLMNQHWMPFGLGSRTCIGRHVSMLEICKLVPRLVRDFDFELA
GDLALPNSEWELKNHWFVFQNNFFVRVRLRTSQ*
>CYP5080A5 old name = CYP532B3
Nectria haematococca
fgenesh1_pg.scaffold_9000319
Necha1/scaffold_9:1041947-1043927
44% to e_gw1.6.751.1
52% to CYP532B2 FG07977.1 AACM01000323 from
SPLKN on
N-term in this model looks suspect, can extend
back from SPLKN in exon 4 to a start
MET Without adding any new exons at the
end. This matches CYP532A2 from
amino acid 2
on Therefore, the first 3 exons of this model
are probably not real.
MYAYGFAPRQPEA (1)
ISLHTKHKSIILYTHFHDDLGSPHRTIAS (1)
LRWSIGSPHGTTREGLLLKWSHIPIEQISARHI (0)
MAALIYLVPLCSLALVVALK
VLSRVYQTLFSPLKNVPGPTLARFTDLWYLNRVSRGHFERDNINLHRQYGPIVRYGPNRYSFDHP
EAAQIIYGVGKADKFAKSSFYRTFTTPDPNQPSIFAHENIKEHSQLRRLYQSTHAMSALISYEDFVDECA
DLFDQRLREMAADPNSTENKPLVDMGHWFQCYAFDVISMITYSTRLGFLDQGMDIAGIMASLEGFLAYAC
RVGIFSWIHPALFAIRNWFAGNSGTGIQYVIQFTERCMKEHQSKPKNLDVENEDVQRMDFLSKYVARHRK
DPATYDAWYVLSGCASNMTAGSDTTGISLSAILFFLMKNPEVTQKLRQEIEQHQQRAADPRHFSFKETQD
MEYLQAVLKEGLRLHPATGQPLERVVPKGGATIAGQFFPEG (0)
TIVGVNTWVEHVNSTIFGPDADVFRPERWLEGDKQKLDAMNRHWIP
(0)
FGMGARTCIGRHISTMEISKLIPRIIRDFDFSFPNNNFNVAELETLNYWFVKPKGFKVYIKARK*
>CYP5080A6 old name =
CYP532B6 Nectria haematococca
e_gw1.1.1091.1
Necha1/scaffold_1:3107512-3109250
49% to 532B3 fgenesh1_pg.scaffold_9000319, 50%
to 532B1
This gene model seems correct
MTAGRDIFSSLSSISGFPIWLGAILALTIFAILFTLLRAGLSPVRAIPGPFLSRFTDLWYLWRLYRGQFE
QENLELHQRY (1)
GPIVRLGPNRYSFSHPDALKAIYGPSAAHLFPKSPSYRPAAPPDPEKWTLFADEDIQRHA
KHRRLYQSTYSMSSLVTYEAYVNQCADLFSLRLSELADAGVQADMGYWFQCFAFDVIGLITYSKRLGFLE
RGEDVGSIIKTIDNEMVYFVVAGVYSFLHKLAFPIRNWLAGKEGTGRTYLMNFTKERVIEHQDRPHVVTA
EDAEAKKVPLDFLSKFFGKHVEDPGKFTMYHVLAGCASNIVAGSDTTATSLSGILYHLLKNPQVLQRLRQ
EIEEFDHEDFDGRTISWTQSQKMPYLQAVIKEALRLHTAVALPMERVVPQGGAEICGHYFPGG
(0)
TCVGFNNWVYHRNKAVFGEDAHEFKPERWLTSDSEQLSAMNKNLIS
(0)
FGAGARTCIGRHIAALQMSKLVPRLVKNFDFTLCEDISGPEHQWTTKNYFFLKPTNFRVSVRAKA*
>CYP5080A7 Fusarium oxysporum
80% to CYP5080A2
FOXG_09972
FOXG_09973 join these two models
MTSPIAIFAIPAVVLALLLRFIVQSF
RSPLRTVPGPTLARLTDGWYFWKVWKGSFQDVNLDLHKKY (1)
GTIVRYGPNRYSFNDPEAAKTIYGLGTHFPKSSWYSAWASPGTWAIFSDQSVKRHNQNRKLYQATYA
MSSLVHYEPFVDDCADTFAQRLSEMSNTSTHLPVDMRHWFQCYAFDVIGLITYAKRFGFLDSGDDVGNVIGALEDHLGYA
TLVGIFPSLHKYLFKIRNWLAGGKGTGRAYILNFTNERIRQAQVAPKPVAAESEVTMEDFLTKFLAKHAASPDVFTQYHV
LMGCTSNMVAGSDTTAISLSAVLYYLLKNPDCLQKLRAEIDDLTARGELSKSPTFKESQQMVYFQAVIKEALRMHPATGL
PLERVVPEGGATICGRFFPEGS (0)
TIVGINTWVAHRDTRVFGQDANSFNPDRWLTAESERLSMMNRYYMP
(0)
FGLGSRNCIGRHVSMLEMSKLIPRIIRDFDFSLDSSLQHQNWHTQSYWFVKPLDFKVRIQPRVLEKQRV*
>CYP5080A7 Fusarium verticillioides
96% to CYP5080A7 Fusarium oxysporum = ortholog
FVEG_08540.1, FVEG_08540.2
MTSPIAVFAIPAVVFALLLRFIVQSFRSPLRTVPGPTAARFTDGWYFWKVWKGSFQDVNLDLHKRY
(1)
GPIVRYGPNRYSFNDPEAAKTIYGLGTHFPKSSWYSAWASPGTWTIFSDQSVKRHNQNRKLYQATYA
MSSLVHYEPFVDDCADIFTQRLSEMSSISTHLPVDMRHWFQC
YAFDVIGLITYAKRFGFLDSGDDVGNVIGALEDHLGYATLVGIFPSLHKYLFKIRNWL
AGGKGTGRVYILNFTNERIRQAQVAPKPVAAESEVTMEDFLTKF
LAKHAASPDVFTQYHVLMGCTSNMVAGSDTTAISLSAVLYYLLKNPDCLQKLMAEI
DDLTARGELSKSPTFKESQQMVYFQAVIKEALRMHPATGLPLERVVPEG
GATICGRFFPEGTIVGINTWVAHRDTRVFGQDANSFNPDRWLTAESERLSM
MNRYYMPFGLGSRNCIGRHVSMLEMSKLIPRIIRDFDFSLDSSLQHQ
NWHTQSYWFVKPLDFKVRIQPRISEKQR
>CYP5080A8 Fusarium oxysporum
58% to CYP5080A2
FOXG_17521
MSDISVQFMILGLIGAFDLVKLASLVHGCLF
STLKSIPGPFLARLTDVWYLWHLCKGHFETDNLALHREH (1)
GPVVRYGPRRYSINDPAAVKAIYGLEKAFPKSTWYDAWVAPGKVSLFADRDTRRHSHHRKLFQNNYS
MSSLISYEPYVNECADLFVQRLSEISQTGLPMDMGHWLQCYAFDVIGLITYGKRLGFLDSGKDIGGVMEALEAFLSYAAP
VGIYSKLHPFLFSMKNYVAGSGGTGRAYVISFTRSRVAESMKTPTAVMAGKKTTSAEPFLIKFLEKHEQSPDKFTSTNVT
MGCVANMVAGSDTTGITLSAILYYLLENPLCLAALQQEIDLYYIEGKLSEKPTFQETQQMPYLQAVIKETLRLHPATGLP
LERVVPKGGATISGRFFPEGSIVGIKTWVQHRNQSIYGLDADIYRPERWLITDEEQLSIMNRHWIPFGLGSRTCLGRHIS
RLEVSKLIPRIIREFNYELDGDLAQKGTKWSTFNYWFVKPKGFMVRISSRYKS*
>CYP5080B1 Aspergillus nidulans AN7772.1
40% to 532A1 49% to 532B1 53 clan
MHLLAFLLLPPLFLIARYLATLLYTIYRTRTLYSIPGPFWARFTRLWYFR
RLWNGHFEEDNVNLHKQYGPVVRIAPDHYSINDHAALKTIYGSGTKFAKS
AWYEGWKHPDPQRWTLFPDRDIKRHGETRKRFSSLYSMSSLVHYEEFVDQ
CADVFFDRLGEFADRDVKFNLGEWFQFYAFDVIGEITYGERFGFLDKGQD
IDGTIGALQNLMAYSSLIGIYHEWHPLLFGPLSRFSWSGAGGRAYIMRYV
QQKIARHSLQKPQSDVEHGPLKTQTFLEKMILARDKDPEKVTDYHVFMMG
LSNVIAGSDTTAISLSSIMYYLLRNPDVLDKLRNEIDEFTVQGKCSDRVT
FKESQEMPYFQAVMKEALRMHSATGLPFWRVVPAGGAEIAGYFFPEGTVV
GVNAWVPHYDDTVFEDAEAFQPERWIEAQKEDPEKWKVMNDMYMPVCCHK
LLQTFGLGSRTCIGKHISILEMSKLIPRILREFDFTTGEKKWNTANHWFV
KPTDFEVKYMTPSRKRK*
>CYP5080B2 AP007164.1f Aspergillus oryzae
old name = CYP532F2
sixth P450 of six on this accession
CDS join(1717617..1717983,1718066..1718266,1718322..1719073,
1719123..1719320)
52% to rev fgenesh1_pg.scaffold_7000447= CYP532B4
72% to 532F1
MYILLLLPVLIVSYHVLHLIYITLTTKSLLSVPGPFIARLTKLW
YFDRVRRGHFEEDNVRLHERYGPVVRIAPDHYSISDRAAVKLVYGTGTKFTKSAWYEG
WKHPSPERWTLFPDRDVRRHAETRKRFSGLYSMSSLVHYEEFVDHCADIFSQRLTEYA
QREGSLNLGHWFQCYAFDVIGEITFGKRFGFLDQGDDIEGTIAALQKTMVYSTLIGIY
PEWHPRLFELLSHFSWSGAGGRTYIMRYVQEKIRRHSEPAKRDPEQGTLQTQDFLEKM
ILARDKDPEKVTDYHLFMMGLSNVIAGSDTTAISLSSIMYHLLHYPAVLEKLRREVDD
FTAQGRCSARVTFKESQEMPYFQA VMKEALRMHSATGLPLWRVVPAGGAEISGYYFPE
GTTVGINTWVAHYDEEIYPDAKKFRPERWIEAEADPERLKIMNEMYMPFGLGSRTCLG
KHISILEMSKMIPRLIRDFDFTTTSQKWSTENYWFVKPTDFVVKVRRRTSSAKQA
>CYP5080B2 Aspergillus flavus
100% to CYP5080B2 Aspergillus oryzae
AFL2G_06254 revised
MYILLLLPVLIVSYHVLHLIYITLTTKSLLSVPGPFIARLTKLWYFDRVRRGHFEEDNVRLHERYGPVVRIAPDHYSISD
RAAVKLVYGTGTKFTKSAWYEGWKHPSPERWTLFPDRDVRRH
(1)
AETRKRFSGLYSMSSLVHYEEFVDHCADIFSQ
RLTEYAQREGSLNLGHWFQCYAFDVIGEITFGKRFGFLDQGDDIEGTIAALQKTMVYSTLIGIYPEWHPRLFELLSHFSW
SGAGGRTYIMRYVQEKIRRHSEPAKRDPEQGTLQTQDFLEKMILARDKDPEKVTDYHLFMMGLSNVIAGSDTTAISLSSI
MYHLLHYPAVLEKLRREVDDFTAQGRCSARVTFKESQEMPYFQA
(2)
VMKEALRMHSATGLPLWRVVPAGGAEISGYYFPEGTTVGINTWVAHYDEEIYPDAKKFRPERWIEAEADPERLKIMNEMYMP
(0)
FGLGSRTCLGKHISILEMSKMIPRLIRDFDFTTTSQKWSTENYWFVKPTDFVVKVRRRTSSAKQA
>CYP5080B3 Aspergillus fumigatus Af293
GenEMBL XP_753882.1 also EAL91844.1
71% to
CYP5080B2
revised 3/12/2009
MFLIIVIPIVILLYPFLSTLYTTLRTRSLRRIPGPFLTRLTKLWYFYRVRAGHFETDNIALHRRYGPVVR
IAPDHYSISGSAAIKTVYGTGSKFTKSAWYEGWKHPDPNQWTLFPDRNIKRHAETRKRFSSLYSMTSLVH
YEAFVDRCADLFCMRLREFAARGEEFNLGHWFQCYAFDVIGDITYGQRFGFLDRGEDIEGTIAALQRLMT
YSTLVGIYPEWHPRLFGPLSRFSWSGAAGRAYIVRFVQEKIRGLSVKADPGQVERGPLATQNFVEKMMLA
RDKDPEKVTDYHVFMMGLSNVIAGSDTTAISLSAIMYHLLRYPAVMEKLRREIDAFAADGKCSDSVTFRE
SQEMPYFQAVIKEALRMHSATGLPLWRVVPDGGVEINGYFFPAGTVVGINTWVAHYDEEVFPDATTFRPE
RWIEAESNPEKLRAMNEMYMP (0)
FGLGTRTCLGKHISILEMSKLIPRIVRDFDFSTRNENWETENRWFVKPTNFTVRVKQRPVAGGTKVTA*
>CYP5080B3 Neosartorya fischeri
95% to CYP5080B3 Aspergillus fumigatus = ortholog
NFIA_079750
MYLIIIPIVILLYPFLCTLSTTLHTLSLRRIPGPFLTRLTKLWYFHRVRAGHFETDNIALHRRYGPVVRIAPDHYSISGR
AAIKTVSGTGSKFTKSAWYEGWKHPDPNQWTLFPDRNIKRHAETRKRFSSLYS
MTSLVHYEAFVDRCADLFCMRLREFAA
RGEEFNLGHWFQCYAFDVIGDITYGQRFGFLDRGEDIEGTIAALQRLMMYSTLVGIYPEWHPRLFGPLSRFSWSGAAGRA
YIVRFVKEKIRGLSVKVDLGQAERGPLETQNFVEKMMLARDKDPEKVTDYHVFMMGLSNVIAGSDTTAISLSAIMYNLLR
YPAVMEKLRREIDEFTAEGKCSDRVTFRESQEMPYFQAVIKEALRMHSATGLPLWRVVPDGGAEINGYFFPAGTVVGINT
WVAHYDEEVFPDATTFRPERWIEAESNPEKLKAMNEMYMP
FGLGTRTCLGKHISILEMSKLIPRIVRDFDFSARSENWDT
ENRWFVKPTNFTVRVKQRPVAR*
>CYP5080B4 Aspergillus terreus
80% to CYP5080B2
ATEG_08377.1
MYLLLLLPVGLIAYHILSLVYKTITTRSLISIPGPIYTRFTKLWYFNRVRQGHFEQDNID
LHQRYGPVVRIAPDHYTINDRAAIKTIYGTGSKFAKSAWYEGWKHPDPERWTLFPDRNMKRH
(1)
AETRKRFSSLYSMSSLVHYEEFVDQCADIFAQRLSEHAQRAQRLNLGYWFQCYAFDVIGHITFGQRF
(1)
GFLDEGRDIEGTIAALQKVMTYSTLVGIYPEWHPRLFGPLSKFSWSG
AGGRAYIMRFVQEKIRQHNGQPKSGADQGALQTQDFLEKMMLA
RDKDPEKVTDYHMFMMGQSNVIAGSDTTAISLSAIMYYLLHHPAVLEKLRREIDDFTAQGRCSPRVTFKESQEMPYFQAV
MKEALRMHSATGLPLWREVPAEGAELGGYFFPEGTVVGVNTWVAHYDEEVFPDAKSFRPERWIEAEQDPERLKMMNDMYM
PFGLGSRTCLGKHISILEMSKLIPRLIRDFDFHTDVQQWSTENFWFVKPTDFEVTVRSRASSVAGTV
>CYP5080C1 old name =
CYP532G1 Nectria haematococca
e_gw1.6.751.1 with modifications from
gw1.6.1186.1
Necha1/scaffold_6:2410473-2412365
60% to gw1.13.252.1
44% to 532B2 F. gram. 43% to 532D1 Aspergillus
nidulans
add cyan back to exon 5
MIIEYITLPLLTMIAGAALLVMTLRCLVSPFFSPLRHVPGPMAARFSRYWYMKRVSEGNFHKLNIQLHRQH
(1)
GPIVRIAPNQFSIDDPEATKIIYGLAKGFVK (0)
SAWYKASGDPFASHTDLFTDLNPTRHASNRRLVANLYSATSLRNMEGDVDECIDML
VTRLDQLAESRQAFDLQFWMQSYAFDVIGQIT (0)
LGKRFGILDEGADKDDIFGNLHEYLKYCAVIGVYDELHRFLFWLMTKFPTKGLTGIGTFTVEQIEMSRN
RRKNDPDSKTRMDFLSRTMGLHENNPAKFPLPAVQSTCLVNIGAGSDTTSISLCSILYNLITHPDALQK
(0)
LRDEIDQKLEELGDTTRIPFKDTQAMPYLQACIKEALRLHPATGLPLARVVPQGGATISGTFFPQG
(0)
TVVGINTWVAHRNPQVFGEDVEAFRPERWLDSDKQRVSEMDSCWMP
(0)
FGAGSRTCIGKNISLLEMNKLVPVLVREFDFVACDPSKGTHEDYWLVKQRNMMCMVSRRNNVST*
>CYP5080C2 old name =
CYP532G2 Nectria haematococca
gw1.13.252.1 short on N-term and C-term
Necha1/scaffold_13:992678-994370
62% to e_gw1.6.751.1
green from gw1.13.524.1
note: possible gc boundary at intron 1 and
intron 3
MSALLLTAQNVSLLGVGLLLLAIAQTVGQALFSSLRAVPGPISARFSRFWYLRNVSKGTFHETNIQLHKKY
(1)
GPVVRIAPNQYSFNDPNAIKTIYGIGKPFIK (0)
SSWYKASSDPNAQFKDLFTDQNAARHSANRRLVANLYSVTSLRTMESAVDECVDILLDR
MSELARSGKSFDLQFWMQCYAFDVIGQIT (0)
VGQKVGFLEKGTDERNIFSSLHDYLKYCAVIGVANELHGLLSWLMSFLPANGIAYVANFTQASIQEGRKIRSMDS
SLDKAQDFLSKALSLHQANPDKFPDAAIQTLCLTNFGAGSDTTSISLCATIFSLLKHPECLSK
(0)
LRNEIDEKLALLGYVDKIPFKDTQSMPYLQACIKESLRLHPATGLPLARVVPEGGATLSGTFFPAG
(0)
AVVGVNSWVAHRNPDVFGPDTDEFRPERWLTTDKEKLKMMEASWMP
(0)
FGAGSRTCIGKNISLLEMNKLVPALLKRFDFSEAASCNVHMENYWLVKQKGMICKVTSRDMGMV*
>CYP5080D1 Aspergillus nidulans AN5553.1
43% to 532B2 53 clan
revised 7/19/07
MLSSLLSLPAILSFFLALCIIQLVRSLAKSPYGSIPGPALARFTNAWYLW
QMRRGDFHRTNIKLHQQNGPVVRIAPEYFSISDPSAVKPVYGHGTKFIKS
EWYKAWNVTPDPDQTNLFSEQVSQRHAENRRKVASMYSMSSLVAYEPYVD
NCIAVFKQRLNEISVQGKTVDMAHWLQCYAFDVIGEITFGSRFGFLDAGN
DVGGVMKSIEDGLAASSYLGLYPWIYPFYLRVLGYLRQGLSYMNEFSLLH
IQETRAAMKGSHKDLPSYMAVKLVQAQTENPHRISDWDILATVGANVGAG
SDTTAISLSSTLYHLYRNPGCLAKLREEIESAGIGTVIPAFKSTQEMLYL
QAVLKEALRVHPGTGFPLFRVVPKGGQVLAGQFFPGGVNVGINSWVLHYD
TNIYGADASIFRPERWLEADEEQLKTMEQNYMPFGIGSRTCLGKNISLLE
MGKLIPVLVRDYDFDIQGEGDLEARNRW
FVKPVDFWIKVTKK
>CYP5080D2P Aspergillus niger
gw1.11.656.1|Aspni1
52% to CYP5080D1, frameshift and deletion before PERW
AIPGPLWSRLTNLWYLRQMVKGDFHNTNIKLHRQKGTIVRIAPNYYSLSDPACLKTIYGLGTKYVKSSWYDAWNTEEDLT
WTNLFSERDPKKHAANRHKVASMYSMTTLTSYEPFVDSCIGLFRRQLDQAGSSDSAVNLAHWVQCYAFDVIGYITFGERF
GFLDNMLDVSNIMKNLDAAISAATYIGLFIMLRPLIMKILRLMGLLGTDALADFAERNVKMGGSRKATYGAESIGSYSPM
LNKLLEAKKAAPGKFTEWDIMANVISNVGAGSDTTAISLSAVFYFIYSNPETLQRLRDEINVAGIDGIPRFSDTQSLPYF
QAVLKECLRLHPGTGFPMFREVPEGGAVISGQFFP
XXXXXXXXXXXXXXXXXXXXXXXXXX
RPERWLHASEAEKALMERSYMPFGMGSRTCIG
KNISLEMNKLIPLVVREYDVEILGHGQGLKTCNHWFVKPV
>CYP5080D3 Aspergillus clavatus
61% to CYP5080D1
ACLA_044480
MLSMLSILFIVLTSFLIRSILASIRSPCRALPGPFLGRFSNLWYLWQMKRGDFHKKNIQLHQTLGTIVRIAPNWYSVSDP
TALKTMYGHGTKFEKSEWYDAWNLGKNKSLTNLFSERSSTKHARDRKKVAALYSMTSLMAYEPFVDDCVAIFEQRLREFA
KQGCFIDMGHWLQCYAFDVIGEITFANRFGFLDAGNDVGGIIKSLDTSFTVASYLGLYVWLYPLFVRISIFLGLGQTYVQ
QFTAHHVQEAKATMGNHSSNLPAHMAMKLTQAQMANPDSLSDWDILVSAGANVGAGSDTTAITLSAVLYHLICSPEYLAK
LREEIMRSGIGQNPTFQQAQAMPYLQAVLKEALRIHPATGFPLFRVIPKGGAVLAGHFFPEGTNVGVNSWVAHYDTNVYG
PDAAVFRPERWIESSPEQLKLMERNYMPFGLGSRTCIGKNISLLEMSKLIPVLVRDFDFELGDGLRENEWETRDRWFVKP
RNFQVRIIQRA*
>CYP5080E1 Aspergillus oryzae
GenEMBL BAE63486.1
42% to
CYP5080B1, 41% to 57A3, 42% to 57B2
42% to
5038A1, 43% to CYP5080C2, 43% to 5080C1
in the
CYP53 clan part B
MNDERIVLTQDKGQSYTAQLLYLIVAGYIAHTVYYAYWGPTARIQGPWLARFTRLWELLKVSKGHFEQVN
IDLHKKYGPIVRISPNTFSISDPSAIKQIYLGRTTLMKSKFYEPFGDPLDPNLFSETDIKKHAQSRKAVA
HLYSMSFLVTYEGSADRCNVQLCAKLRDFARHRTAFDVPTWMQFYAHDVIGEITFGEPFGMMAKGQDEHG
IADSIDETIAYASRMAVIPELHRWVSWFGRVAHLKTPFHNIQKYILEQIDSRSGSDSVGIDFLKKLLTLR
EDDKITQLDIEKTVGNNIMAGADTTAISLSAVIYSLLKNPGTETKLREDIDTLAAAGKLSNPVTFEQARH
MPYLQACIKEALRVHPAVGRPLLRVVSPEGLTIAGQYFPGR FQGNSRYQCL
VAHYNEDIFGRDATTFRPE
RWLESDKEKLSVMEQSLLA FGAGVRTCIGKNLSMLEMSKVIPELYRQFEFELSESEGAWMTWNNWFVKPA
FECYVRLREGV
>CYP5080E1 Aspergillus flavus
98% to CYP5080E1 Aspergillus oryzae
AFL2G_11025
Note: one frameshift exists, possible
pseudogene
MNDGRIILTQDKGQSYTAQLLYLIVAG
YIAHTVYYAYWGPTARIPGPWLARFTRLWELLKVSKGHFEQVNIDLHKKYGPIVRISPNTFSISDPSAIKQIYLGRTTLM
KSKFYEPFGDPLDPNLFSETDIKKHAQSRKAVAHLYSMSFLVTYEGSADRCNVQLCAKLRDFARHRTAFDVPTWMQFYAH
DVIGEITFGEPFGMMAKGQDEHGIADSIDETMAYASRMAVIPELHRWVSWFGRVAHLKTPFHNIQKYILEQIDARSGSDS
VGIDFLKKLLTLREDDKIMQLDIEKTVGNNIMAGADTTAISLSAVIYNLLKNPGTETKLREEIDTLAAAGKLSNPVTFEQ
ARHMPYLQACIKESLRVHPAVGRPLLRVVSPEGLTIAGQYFPGR
FQGNSRYQCL &
VAHYNEDIFGRDATTFRPERWLESDKEKLSVMEQSLLA
FGAGVCTCIGKNLSMLEMSKVIPELYRQFEFELS
ESEGAWMTWNNWFVKPAFECYVRLREGV*
>CYP5080F1 Aspergillus niger
fgenesh1_pg.C_scaffold_7000061|Aspni1
50% to CYP5080D1
MILAPIPTFSALALGLFLWVFVKRALSSDRDIPGPFLARFTRLWYLRQMTRGDFQYTNIRLHRDHGKIVRIAPGWYSLTG
LDAIKTIYAHGSKFIKSEWYEAWNFSPDTRDHNLFSVQNVADHSSARRKVAAMYAMSAIVSYEPYVDNCIRRLRKKLDST
AKDGSTLDLGHWLQCFAFDTISEITYGERFGFLDNGKDINNLIANLDQSFVISSLVGLLIWLRPLALFLGSFFATSDALY
VARFNAQKFKELSQEYLKNPSPPGLIPMVRRLLHARQEDVKGLTDKDIQTSAASNIGAGSDTTAIGLSSVVFYSYRFPET
LKKLRQEIQDAGLGSEPSFQETQKLPYLQAVIKESMRLHPGVGFPLFRIVPKGGAVICGRFFPEGTNVGVNSWVIHRDES
IWGSNADDFVPERWLTEDSEKLRIMEQCLVPFGIGSRTCIGKNISLYEINKLIPQLVRDYDIDIQQEGGTDVRSNNMWFV
KPVQFDIKIKQRSDGSGV*
>CYP5080G1 Mgr048 Mycosphaerella graminicola
48% to CYP5080B2 Aspergillus
oryzae, top 13 hits are CYP5080s
MHPVIIVYAALAALIAKFFHFIYTTLTSPVRDVPGPFAARFSKLWYVFAIWTGKAEQINIELHRKHARDGEYYAPVVRLGPNMYSISRPEKAIYGIGSKATKSSWYDTWYDPALEPSLFPDRDPQRHANKRRMFQSMYALSSLLHYEKYVEAVQSIFQERLSEISCDGKQVDLHHWLQCYAFDVVGNITYGRRFGFLDEGQDVGQMITSLDSVLKYATFMGIFSWAHRWVYKYSSNLPGMRGGGLPYLASTVRKELDSRIAQRGKEEKDGGRVHDLDAPRDFLDLALDAEKDPDKAMTMRHVYAMLLSNVVAGSDTTAVSLSSVIFYVARDPRVLARLREELDQAVQDGKATPDCAAFRETQDMPYFQACIKEGLRLTAATGLPLWRVVPAGGVEMLGHYFPEGTEVGINTWLAHYDQTIWGQDVAGFRPERWIEAQEGDGNKLKVMDSNFMPFGLGSRTCIGRHISYLEMCKVIPMIFLNFDIELVNTKLTTENHWFVKPTNFAVKLRRRQN
>CYP5080G2P Mycosphaerella fijiensis
53% to CYP5080G1 Mycosphaerella graminicola
fgenesh1_pm.C_scaffold_27000021
MFVTYGLIAAAIIALLYPLFRAATSPLKDVPGPFLARFTRLWFFRSRWNGHAHLDNIALHGKYAKDGQFFAPIVRLGPNM
YSISRPDKAVYGIGSKMPKSSWYEGWKHPSPERWTMFPDRNIQRHAETRRKFQSMYSMSSLLHYEEYVESTQDVFQTRLE
EMVQDGRTVDMHHWLQCYAFDVIGNITYSRRFGFLDRGEDVENVLASLHSIMSYSTLAGIYSWAHPLLYKLLEKLPGSGA
QGRNYIIQYTQRRIREREAERLLQSEKRHDHDHDHQHAPRDFLDITLDASQDPENAMTPYHVSMSNIIAGSDTTAISLSS
IFYHLYTNPKSLKKLRQELD
TTAGSSNRGRITWKES &
LKFSYLQACIREGLR &
ECVLRLWREVPPGCGGGGIEILG &
GFFPEGTEVGMNSWVAHYDAEIFGADVEEFRPERWIDADGEELKRMEGLFVPFGLGSRTCIGRH
&
FSYLEICKVVPMIVGGGGGGGGFDLELVDGDKKKKGKFETRCFWFCKPEGF
RVVVKARVL*
>CYP5080H1 Mgr042 Mycosphaerella graminicola
44% to CYP5080B2 Aspergillus
oryzae,
44% to CYP57B2 Nectria haematococca, these two families overlap
yellow region not in JGI model estExt_Genewise1Plus.C_chr_31342|Mycgr3
MSLLTDTRAILLLLVVLPLLIISYQVISDPLRSIPGPLLARFTRLWELYQVIKGDFEKTNIRLHRKYGPVVRLAPGRYSVDDESALKVIYGLGSGFTKSSFYTAAQDVDQHRINLFAERDPQVHLTARRKVASLYSMSNLLSYEPFVDQMNDLLCSKLTLHVEKGSPVNIPTWMQYYAFDVIGEMTIGKAFGMMERGHDSMDILDAIDGGIRHASRFGLFPELHAPTIRAMKRLGVSSDMQGLTAFIGARIQERAVGKTESNREDFLTKTMKLIDMGSIDLSNQFGVIGKIKNGLSHTVTDTLLIGANIAAGSDTTAVSLSAVIYYLLRDPACAQKLRNEIDSFDREGKLSARATFKETQDMPYLQAVIKEALRMHPATGQVLDRVVPPGGSQICGYFFPAGTCVGANAWTVHRNQGIWGLDADKFRPERWLESSKEELSRMNEGYMPFGLGSRTCIGKNISLLEMSKVITQLYRRFEFDYPDPAAPTDWKTNNVFFVKQSFACRVSPRV
>CYP5080J1 Coccidioides immitis
52% to CYP5080B2 Aspergillus oryzae
CIMG_04922.2 added N-term
MLGLSSMILGAFIALRFLLSITSALFSRNRSIPGPFLARFTRFWYLREIHRGHFEKVNIELHRRH
(1)
GKIVRIAPNEYSVDDPEAVRTVYGPGSKFRKADWYAGWAHPDPSRFTLFTD
RNSKRHAAERRKVSAAYSLSTLVSYEGFVDDCVG
IFDQRLRGFA
DQKLGINFGHWLQCFAFDVIGEITFSKRFGFLDAGEDVGEIMESINNKMAYSTMVGVYPKIHPPLFRLLS
FFRGSKATGEEYNVRFALDNISERKTRFTTVPSNGPTDFLTKFLEAHSADPEKFTNYNILMGCLTNIVAGSDTTSISLSS
IMYNLCRNYDALAKLRSEIDTMTAEGRLSNPVTFKETQNMPYLQAVIKEGLRMHPATGLPLARVVPDGGVTLTGRYFEAG
TVVGINSWVAHMNTSVFGADAHLFRPDRWLTTDTAQLSKMDHYFLPFGLGSRTCLGKNISLLEMSKLVPQLVRNFDFELV
NPEKELATRNMWELHELDQGYFLR
>CYP5080K1 Fusarium oxysporum
49% to CYP5080J1 Coccidioides immitis
FOXG_04631
MALGGLLEATQTQYLPLVFTSCFLVWYFHLLIHSLSSPLRSVSGPPLARFSRVWYFRQVWTGRFPWTNIELHRKH
(1)
EGPVVRIAPNEYSVDDPSAVKTLYGHGTAFTKGPWYDGSTNLKDEKSNLFANRDIKTHAAERRKVASLYSMSTLVKMEDAVNDCI
VRLEQRMRDLARW (0)
PINLQWWMQCYAFDVIGSIT (0)
VSKRFGFLDSGKDPMDLVSGLHDFLTHAARIGVYPDLHPILFKLGKLAGKFQSAGTNGIIRAFIFTRKQIGEYKA
MNKFLKSKADDEEAFLPRLLRLHHEKPESVTEEDVMRTCAINVVAGSDTTSISLTGVMWALLRNPKAMAK
(0)
LRAEVDDKYSSGEIGDPISFGDAQKMPYLQAVIKEGLRL
HPAGGLPLSRIVPKGGATIAGHFFPEG (0)
NIVGINAWVAHRNADVFGHDADEFRPERWLVNGADTQRMDRYWLT
(0)
FGHGSRTCLGKNIALMEISKLIPQ
LIRKFDIELADPQMKLETENVWFVKQTNVIVEIKERALSPNFSGS
>CYP5080L1P Fusarium oxysporum
47% to CYP5080C1, EXXR motif missing
FOXG_07410
MKSMSLYVLLVFCLTLGWFILTLVNVLRSPLRRVPGPFLARFTRLWLLKQVYFGTYPKTSIELHRKY
(1)
GPIVRIAPNEYSIDDPAAAKIIYGSGRGFTK
SQWYYASGNPISPLPNIFAEPNPHIHAQARRKVAAAYSMTNLVQLEPFIDKCSAVLRDRLEEFARSGTSVEI
SHWMQCYAFDVIGMMT (0)
LGKRFGFLDSGEDIQGI
MSSLSQYLVYCANVGVFPEWHKTLFRRQMRSQTVSGLTHVRGFANAQ
LEEKREKVKADDVPHPNVAEDFITKFLRVQAQDPTKITNADISSVCTMNIGAGSDTTSISLTSIIFNLIKHPRVLERLRAEIKEHESQGTISDPIKFVQA
(small deletion)
GRVVPSDGATLAGQYFPPG
TVVGINAWVAHANTKVFGHDAHVFRPERWLDYPELVKEREAYFMT
(0)
FGQGSRTCLGKNISLMELSKAVPQIVRHFDFVPDTESGYPEYVMENVWFVKIREFHCKVYSRNRH*
>CYP5080L1 Fusarium verticillioides
88% to CYP5080L1P Fusarium oxysporum = ortholog
FVEG_04340
MKSMSLYALLAFCLTLGWFIVTLVKFVRSPLRRVPGPFLARFTRLWLLKQAYFGTYPKTSIKLHRKY
(1)
GPVVRIAPNEYSIDDPAAAKIIYGSGRGFTK (0)
SPWYYASGNPISPLPNIFVEPNPHIHAQARRKVAAAYSMTNLVQLEPFIDRC
SAVLRERLEEFSRSGVSVEISHWMQCYAFDVIGMMT (0)
LGKRFGFLDSGEDIQGIMSSLSQYLVYCANVGMFPEWHKTLFRRQMRSKTVSGLSHVGKFANAQLEE
KREKVKTDEEADGNAAEDFVTKFLRLQSQDPGKITDADISSVCNMNIGAG
SDTTSISLTSIIFNLIKYPRVLQQLRAEIQDRESRGIISDPIT
FAEANKLPYLQAVIKEGLRIHPATGLSLGRVVPPDGATLAGQYFPPGTVVGINAWVA
HANTKVFGHDAHLFRPERWLDYPELVKERELYFMTFGQGSRTCLGKNISLMELSKAVPQ
IVRHFDFAPDTETGEPEYETENVWFVKIREFYCKVHSRDRQ*
>CYP5080M1 Mycosphaerella fijiensis
46% to CYP5080J1 Coccidioides immitis
43% to CYP5080L1 Fusarium verticillioides
fgenesh1_pg.C_scaffold_22000072
MGSGTPYLIFGLLVWIFSRLTRAYCFAPLRSIPGPFLACFTRFWYATHAYYGHIEQDLVELHKRHGKVVRVAPHEYSIDD
PEAVKIIYGRGSQFRKADFYAASERPGHPNLFSQRDPARHDQDRKKYNYAYTMSAMVSYEKYVDDCIELLGQRLVEQKDA
VDMAWWLHCFAFDVIGAITFSKRFGFLDAGDDVHGLIKTVHGNAFYATIFGIFHEVYASMFHVKAWLSKVGILNQSGQTF
MQDFAGGLLRERRQHLDDVDQGSLSQEADDGRPKDFLTKYMEQHLKDPSRFNIGDVMNGLGANINAGSDTTSITLSALLY
HTHKNPTVLAKLRQELEESESNGKMSSPITFKQAQSLPYLQAVVKETLRIHPAVGITLPRVVPRGGAHIAGHFFPADEIV
GVNPYVAHRNHEVFGADANVFRPERWLEQNVKAEMEKYFMAFGVGRRSCVGRNVALLEITKAVPELLRRFEFQLLGECEW
RTRNWLFIMPEKLGMSVRERR*
>CYP5081A1 Aspergillus fumigatus Af293
GenEMBL XP_751355.1 also EAL89317.1
50% to
CYP5081B1, 46% to CYP5081C1, 43% to CYP5081D1
MRTYAIRPVSNRLPGPIEPKKHRRDRDNSTTGSLYNALIHPVQGEKTITSTMIRVAEFQPFLNTISVLQV
LAAIFIGALTYRLIDAFFLSPLRSIPGPLLARLTTKRANVDTFSGKVTQTVDKDVARYGDVYVYKPRAVC
INHPDDIRAVLGSQEFRKAAFFDIFNDGNTPNIVSLREPELANRRRRQLGPFFNYAYLGRAEPLILQHGY
QAIRTKWDALIQANSGRPTEVNYRTDTQLVTFDIMSALAFGRNFNAISRGSSSIMKWAGLIMEMLESPAV
LALLSLLPFSLIMRPWKIMYRELAAFSSDAVDMRKQLLAEDSTEKPLDMLQAFIDAEDPESKIKMSPHEV
QAESIMMMLAGSETTSSAIMWTFHLLLLYPETLRRAVHEVRSAFSLNHLVTYKDVRSSLPYVEACVYEAL
RHSPTTAGLTPRISHSTGITLQGYYIPPGTEIYVNLRSPSMHPSLWDDPARFNPDRFLDSDNNKRLLFTF
SYGPRNCLGRNLAWVEMLTIVANVLKDYDIALTEDSLFGPHCTDENGLPVLMPAKCFIASFPAKPERDCR
MVITRRMAGVKACAREYSPC
>CYP5081A1 Neosartorya fischeri
97% to CYP5081A1 Aspergillus fumigatus = ortholog
NFIA_101370
MIRVAELQPFLNAISVLQVLAAIFIGALTYRLIDAYFLSPLCSIPGPLLARLTTKRANVDTFSGKVTQTVDKDVARYGDV
YVYKPRAVCINHPDDIRAVLGSQEFRKAAFFDIFNDGNTPNIVSLREPELANRRRRQLGPFFNYAYLGRAEPLILQHGYQ
AIRTKWDALIGANSGRPTEVNYRTDTQLVTFDIMSALAFGRNFNAISRGSSSIMKWAGLIMEMLESPVVLALLSLLPFSL
IMRPWKIMYRELAAFSSDAVDMRKQLLADDSTEKPLDMLQAFIDAEDPESKVKMSPHEVQAESIMMMLAGSETTSSAIMW
TFHLLLLYPETLRRAVHEVRSTFSLSHLVTHKDVRSSLPYVEACVYEALRHSPTTAGLTPRISHSTGITLQGHYIPPGTE
IYVNLRSPSMHPSLWDDPARFNPDRFLDSENNKRLLFTFSYGPRNCLGRNLAWVEMLTIVANVLKDYDIALTEDSRFGPH
CTDENGLPVLMPAKCFIASFPAKPERDCRMVITRRIE*
>CYP5081B1 Aspergillus fumigatus Af293
GenEMBL XP_751354.1 also EAL89316.1
50% to
CYP5081A1, 50% to CYP5081C1, 43% to CYP5081D1
MALPIILCLAVILWTSWRLLDALFLSPLHRVPGPVLARLTPLRAIYARLPSRVIPAALADFHSYGDIYLS
KPRTITISHPRDVRAILASSEFQKIDVYHGLNDPVMANIVTFSDPKLASRRRRQIGPYFNPSYLAKMEEL
ILRCGCRAVADKWGRLIAQQGHGPQKSVKVNYRHDLQLATFDIMSALAFGRWLDSLKEEGESVAIVEWIM
ATAVYIGVRINFRLLMVFPFSRLVRRWTRAYAEFVQFSKHAVASRKELLAQGCQKPVDLLQAFIDAEDPD
SKVKMTTVEVQAESVGMQLAGSETTAASLTWAVHLFTLYPEYYRIAVDEVRGQFGPNHLITYADCSRLVF
LEAFVYEMLRYTPITSSFMPRVSFTKGTTLQGHYIPPGTEIAFNLIAMNNREDVWEEPERFLPDRFLKDP
DLKRSVFAFSYGTRSCIGRHLAWMEMMTILANLLKDYDWSLPEDSLYGPHHVDEKGIPIRMPSKCHIVFA
PTHPDRDCQLVISRPKT
>CYP5081B1 Neosartorya fischeri
95% to CYP5081B1 Aspergillus fumigatus =
ortholog
NFIA_101380
MALPIILCLVVILWTSWRLLDALFLSPLHRVPGPVLARFTPLRAIYARLPSRVIPAALADFHTYGDIYLSKPRTITISHP
RDVRAILASSEFQKIDVYHGLNDPVMANIVTFSDPKLASRRRRQIGPYFNPSYLAKMEELILRSGCRAVADKWDRLIAQQ
GHGPEKAVKVNYRHDLQLATFDIMSALAFGRRLDSLKEEGESVAIVEWIMATAVYIGVRINFRLLMVFPFSRLVRRWTRA
YSEFVQFGKHAVASRKELLAQGCQKPVDLLQAFIDAEDPDSKVKMTAVEVQAESVGMQLAGSETTAASLTWVVHLFTLYP
EYYRMAVDEVRGQFGPDHLITYADCNRLVFLEAFVYEMLRYTPITSSFMPRVSFSNGTTLQGHYIPPGTEIAFNLIAMNN
REDVWEEPERFLPDRFLKDPDLKRSIFAFSYGTRSCIGRHLAWMEMMTVLANLLKDYDWSLPEGSLYGPHHVDEQGNPIR
MPSKCHIVFAPTHPDRDCQLVISRPKT*
>CYP5081C1 Aspergillus fumigatus Af293
GenEMBL XP_751350.1 also EAL89312.1
50% to CYP5081B1, 46% to CYP5081A1, 45% to
CYP5081D1
MVEILRFIPLVLLLTLTWRITYELFFSPLRHIPGSLLARLSSKYSILKRVLSDGPQSVQADYQYYGNIYV
HRPNGVSISHPDDIRTVLLSPEFRKTKVYEMLDIEGHASIFTTRDPAQASRRRRQIGPYLNHGYLGRMEG
LIMKYSVLAIKRKWDRLLEESGGQQVTVNYRDHKQYATFDTIGALAFGREFNALTNDDRTVIRWIEATGL
YLGIRKNFPLLKLWPFSRVLRQYRERYERFIAYSKESVTRRKNLLSTVGERPMDLLQAFIDAEDPENPHV
KMTADEVMTESIAMQLAGSESTSFVTSWVIHLLTLYPQHLAKVTEEIRSQFSPSHLITFAECRDKLPYLE
ACVYETLRYSPITSGFLPRISYTKGLTIQGHYIPPGVEIAINLHGAHINKDVWTNPHLYDPTRFLGDDQA
KRNVFAFSYGHRNCIGRNLAMMEIMIIIANILKEYDIALPEDSVHGPWNVDALGRPRIMPTRSALFTTPK
YPERDCRLVVSRRQ
>CYP5081C1 Neosartorya fischeri
95% to CYP5081C1 Aspergillus fumigatus =
ortholog
NFIA_101420
MIEILRFIPLVLLLSLTWRITYELFFSPLRHIPGSRLARLSSKYSILKRVLSDGPRSVQADYQRYGNIYVHRPNGVSISH
PDDIRTVLLSPEFRKTKVYEMLDIEGHASIFTTRDPAQASRRRRQIGPYLNHGYLGRMEGLIMKYSVLAIKSKWDRLLEE
SGRQQVTVNYRDHTQYATFDTIGALAFGREFNALKNDDQTVIRWIEATGLYLGIRKNFPLLKVWPFSRVLRQYRERYERF
IAYSKESVTRRKNLLSSAGEGPMDLLQAFIDAEDPENPRVKMTADEVMTESIAMQLAGSESTSFVTSWVIHLLTLYPQHL
AKVTEEVRSQFSPSHLITFAECRDNLPYLEACVYETLRYSPITSGFLPRVSYTKGLTIQGHYIPPGVEVAINLHGAHINK
DVWTNPHLYDPTRFLGDEQAKRNVFAFSYGHRNCIGRNLAMMEIMIIIANLLKEYDIALPEDSVHGPWNVDALGRPRIMP
TRSALFTTPKYPERDCRLVVSHRQ*
>CYP5081D1 Aspergillus fumigatus Af293
GenEMBL XP_751352.1 also EAL89314.1
45% to CYP5081C1, 43% to CYP5081B1, 43% to
CYP5081A1
MQKACRGHRTAIFRILISLFPFTTLCSSLVGPETQSLHDTMAVATLISILFAVLALRLCYLLIHALFLSP
LRHIPAPFMARVTSKRPLWHLLTGKAEIAARQDYSTFGDIYLCKPNTVYLCDPHDACTVLSSHAFRKTDM
YRVFEYEGIPNVSTFTDPAQAQRRRRQLHPFFNNAYLTQMEPVMLKYGIQALKARWDAQLARHKKVEVNY
RFDTQLAMFDITGALVFGREFHALETSNLVYTKWVNNTLSYMLVSHYFPWVKRVPLSWLVRGLKQSYDDL
VAFSQESIAIRQADLQAGRPKPADLLQALLDAEDPDSKAPMTAREVQAESIAMLVGGSESTSSVISWVIH
FLLLYPEHLQAVVAETRANFPADHTITFNESKANLPYLEACIYETLRCIPTASTSFPRVSDQAIILKGYY
IPAGTEIATNKCAAHLHQPSWQDPDRFYPPRFLNQETYHETRRNMLSFAYGTRFCIGRNLAWAVMMVTLA
NLFKDYEVELPEDSRFGPTIVDAAGRPKIMPTKMGVATMPADPERDCRMVLSVRITE
>CYP5081D1 Neosartorya fischeri
95% to CYP5081D1 Aspergillus fumigatus = ortholog
NFIA_101400
MAAASLISILFAVLALRLCYLLIHALFLSPLRHIPAPFMARVTSKRPLWHLLTGKAETAARQDYSTFGDIYLCKPNTVYL
CDPHDACTVLSSHAFRKTDMYRVFEYEGIPNVSTFTDPAEAQRRRRQLHPFFNNAYLTQMEPVMLQYGVQALKARWDAQL
AKHKKVEVNYRYDTQLAMFDITGALVFGREFHALQTSNLVYTKWVNNTLSYMLVSHYFPWVKRVPLSWLVRGLKQSYDDL
VAFSQESIAIRQADLRAGRPKPADLLQALLDAEDPDSKAPMTAREVQAESIAMLVGGSESTSSVISWVIHFLLLYPEHLQ
AVVAETRANFPANHTITFNESKAKLPYLEACIYETLRCIPTASTSFPRVSDQPITLKGYYIPAGTEIATNKCAAHLHRPS
WEDPDRFYPPRFLKQETYHETRRNMLSFAYGTRFCIGRNLAWAVMMVTLANLFKNYEVELPEDSRFGPTIVDAAGRPKVM
PTKMGVATMPADPERDCRMILSARITE*
>CYP5082A1 Aspergillus fumigatus Af293
GenEMBL
EAL92287.1 also AAHF01000002.1
94% to
Neosartorya fischeri CYP5082A2
86% to
Aspergillus terreus CYP5082A3,
44% to
Leptosphaeria maculans CYP5082B1
35% to
CYP686A1P
MDSAQPTKLDFLTVPATPFSIGGLASIVVLVTVVIGPKAVIDTVLN
(0)
SYLSLVHRIPAADGKKYMSGPAYTFPNGQMVDKFLAARTRSWEWEEKYGKTYRIWAASIPEV
(2)
633544
VITDPKDVEVLYQQSTDHNKAPQANAGWLLTQLLGSGLGLINGTRWSTLRKTLDPMFSHR 633723
633724
AALQYLRDSLDAGAQDYVAGIHQFAKADGQVQTADGKVMVINATQALQRYPFFEVASMFY 633903
633904
GKMSEAEHERLWDLGRRYSEVFAAIVSGGIHRSKLTRY 634017
LNTKAWNNARDYQKAWRDFNREIYTARKMTAPDTPIVALTEAAERGELTPNE
(0)
VTDTIAESTFANLD
IVTHVISSCIILLADSPEVQNDLLQEMEKNKADRENYITRKDTLLHYCLLESLRLRPVL
(1)
SFTFPENPPREKILGNFVVPKDTTIIVDAFAINIRNPFWGPDNRAYRPSRFAGIKQSQLRYNLATFGYGP
RKCLGQHIADKIVKAVVYHLFSKYRVSLMPMQAVEGDFKVDKTSWVALYDVDLKLEPRES*
>CYP5082A1 Neosartorya fischeri
NRRL 181
GenEMBL AAKE02000007.1 NFIA_064360
94% to
CYP5082A1 Aspergillus fumigatus = ortholog
name
revised from CYP5082A2
MDSAQPTKLDFLAVPVTPFSIGVLASIVVLVAVLIGPKVVIDTILN
(0)
GYLSLVHRIPAANGKKYMSGPAYTFPNGQMVDKFLAARTRSWEWEEKYGKTYRIWAASIPEV
(2)
602792
VITDPKDVEVLYQQSTDHNKAPQANAGWLLTQLLGSGLGLINGTRWTTLRKTLDPMFSHR 602971
602972
TALRYFRDSLDAGAQDYVAGIHRFAKADGQMQNADGKGIIINATQALQRYPFFEVASMFY 603151
603152
GKMSEGEQERLWDLGRRYSEVFAAVVSGGIHRSKLTRY 603265
LNTKAWNNARDYQKA
WLDFNREIYTARKMTAPDTPIVVLTEAAERGELTPNE (0)
VTDTIAESTFANLDIVTHVISSCIILLADSPEVQNDLIQEMEKNKADREDYITRKDTLLHYCL
LESLRLRPVL (1)
TFTFPENPPREKILGNFVIPKDTTIIVDAFAINIRNPFWGPDNRAYRPSRFAGIKQSQ
(0)
LRYNLATFGYGPRKCLGQHIADKIIKAVVYHMFSKYRVSLMP
MQAVEGDFKVDKTSWVALYDVDLKLEPRES*
>CYP5082A3 Aspergillus terreus NIH2624
GenEMBL AAJN01000207.1
ATEG_08430.1
MDHAQPTKLGFLAVPAAPYSIGILVFVLVVLAAIGPWAVVDSILN
(0)
CYLSFVHRIPAADGKKYISGPAYTFPNGQMVDKFLDARTKSWEWEEKYGKTYRIWAASIPEV
(2)
337559
VITDPKDVETLYQQSTDHNKAPQANAGWLLTQLLGSGLGLINGTRWTSLRKTLDPMFSHR 337380
337379
TSLQYFSDSLDAGAENYVAGIHQFAKADQVCADGKSIILNATQALQRYPFFEVASMFY 337206
337205
GKMSEEEQERLWVLGRRYSEVFAAIVSGGIHRSKLTRY 337092
LNTKAWNNARDYQTAWREFNREIYKRRKLTAS
EAPIVVLTEAAERGELTYNE (0)
VTDTIAESTFANLDIVTHVISSCIILLADAPEVQKDLLQEMNRNKADRKAYITRKDTLLHYCLLESLRLRPVL
(1)
SFTFPENPPREKVLGNFVIPKDTTVIVDAFAINIR
NPFWGPDNRAYRPQRFAGIKQNQ (0)
LRYNLATFGYGPRKCLGQHIADKIIKAVVYHLFTHYKVSLQPMQAIEGDFKVDKTSWVGL
YDVDLKLDPRGPCVDKVDV*
>CYP5082B1 Leptosphaeria maculans
GenEMBL AY553235.1
sirodesmin biosynthetic gene cluster, SirC gene
note:
a second P450 SirB exists in this gene cluster
Sir B
= CYP5093A1
MESIVYETQPLLRGMVVGTIMLLC
37766
YRYGLALSILQVKHPLAMINFVQSLLIQMKLYLNFMYRITNEKGKPLRGPEFSWPDGQT 37590
37589
VEKFLQGGQKSFSWQAYGPLYRIWTVFRPEV (2)
VITRPEDV 37413
37412
KAFFFDSHTHQKAASSNAGWLFSQILGDCLGLINGERWSRVRHAFDPFFTRKISAQRLPH 37233
37232
IMAAGEGYVNEVHQYDLGGKQAASTINLNAVDAFQRFPFFYVAEIIYGPLGITERVE 37062
37061
LWKLAETHTNIFRRLVQGGIHRYKATKFLSTSAYKETAHFVAAWRQFTLELAQKQLREGR 36882
36881
TSPLTDLMAEVEDGKVTLNE (0)
36745
VLHTIDESLFANLDVTTHVLTWAIVLLGNHPDVQELVRSEIKANTNDLETYMNRKDTLL 36569
36568
HYSLLESLRVRPLL (1) 36527
36474
AFTIPESAQEDKVLSGYRVPKN (0)
TDVVVDVNALHLRNPFWG 36301
36300
ADRMQYRPQRFQVLSKAE (0)
IRYNLSTFGFGPRKCLGQHMAEN 36121
36120
MIKAILVPLLRQFRFKLLADQYKNGEYKVDKTNWVTLSDVNLEMERVPSGGS* 35962
>CYP5083A1 Aspergillus fumigatus Af293
GenEMBL XP_754165.1 also EAL92127.1
AAHF01000002.1
MEAVIV (0)
205012
ASGLCVAYAVYYVYSDALAEVPGPRFAKICP (0) 205089
SWLIRVLWSNKLNQGIREQHQKHGKPSMPFPSTSFTRSDKLTEHKGDVVRLGPSELSFCSLSAH
DTIYNTNSTSFITYGSFQSAVEGLCPPGVTFVSHHSPAEQKELRRVFQPAIRLAVAGGMEAHHKRRFSEL
VAGLNIKPGVPICVNLTGLLERLEWDLIGDLGLGYSVPDRLKDNWNSQKTHQNLIGVAFALGSFLLSRRG
LKMLVDSFGPFWIPKYLDPAHLIDVALKQRAEGKSTFVSQAIPYKNEKYPHLTKQMSSNVTGLIYAAFET
SESSTRAILCALMRDPVRYRNLQQEIRSKFSASKPITDSQLVGLPYLTACINEGLRLWPGLNGQFTSRVS
TGAVVDGVYVPPGCLVSADLYTLQRHPRYWHDPDTFKPERWLDPKNPDEMRAFRPFSAGPRSCPGRQIAL
QKLRLTLAKFMFLFDMQFVNPQFEWDRDVPSGLLWSSVEVMVRMTLLEPPVEPAEAVETAEAVEA
>CYP5083A1 Neosartorya fischeri NRRL 181
NZ_AAKE03000007, NFIA_062670 revised
95% to CYP5083A1 Aspergillus fumigatus = ortholog
~30 kb from PKS, 96%
to 5083A1 probable ortholog
NAME REVISIED FOM
CYP5083A2
MEAVIV (0)
ASGLCVAYAVYYVYSDALAEVPGPGFAKLCP
(0)
SWLIRVLWSNKLNQGIREQHQKHGKPS
MPFSSNSFDRSDKLTGDKGDVVRLGPSELSFCSLSAHDTIYNTNSTSFITYGSFQSAVEGLCPPGVTFVSHHSPAEQKEL
RRVFQPAIRLAVAGGMEAHHERRFNELVAGLNIKPGVPICVNLTGLLEKLEWDLIGDLGLGYSVPDRLK
137863 DNWTSQKAHQNLIGVAFALGSFLLSRRGLKVLVDSFGPFWIPKYLDPAHLFDV
138021
138022 ALKQ
RAEGKSTFVSQAIPYKNEKYPYLTKQMSSNVTGLI
138244
YAAFETSESSTRAILCALMRDPVRYRTLQQEIRSNFSA 138357
138358
SKPITDSQLVGLPYLTACINEGLRLWPGLNGQFTSRVSTGAVVDGVYVPPG (0) 138510
138606 CLVSADLYTLQRHPRYWHDPDIFKPERWLDPKNPDEMRAFRPFSAGPRSCPGRQ
138767
138768
IALQKLRLTLAKFMFLFD 138821
MHFVNPHFEWDRDVPSGLLWSSVEVMVRMTLLEPPVEAVEAAEAVEA
>CYP5083A3 Aspergillus clavatus
59% to CYP5083A1
ACLA_042090, AAKD03000004.1
MQAIIL (0)
SLFFFVAYVIYRTYFDPLANVPGPRFAKLCP (0)
SWIISILWTNKVNYSIDEQHRKHGMILDIPQCAFLPLPFRAAI
LTGTGDVVRLGPTELSFSTISAHDTIYNTDAATFTTPGSIQCCGRNLIHPGLTFVVQRSVAEQKELRKIFAPAFRLALTG
GIETNITNRFNELLAALDIRPGMSKCMNLTHCLEQLEWNLIGDLGLGQPVPDSLRGGWTGYKNHQHMIGAAYELGSFLLT
RRGFPKILDIVGKIWPQILLEEGFLSNLAIKQRTEGKNTFVSQALPYKSEKFPLMGTEMPGNVIGIMVASYETSESTLRA
TLCALLSNPAYYKALQHEIRSTFSTLESITDSQLVGLRFLNGCVNEGLRLWPGLNGKFTSRLSTGGVIDGVYVPAGYIVS
ADLYSIQRNPKYWHEPDSFKPERWFDGQNKDELRAFRPFSVGPRSCPGRQMALQKVRLTLSKFAFSFDMEFVNPDFDWQR
DVPSGFLWGSADVMVRISRSDPPQAIDERVAAA*
>CYP5084A1X # Aspergillus fumigatus Af293
GenEMBL XP_751310.1 also EAL89272.1
Name changed to CYP5121A2
>CYP5085A1 Aspergillus fumigatus Af293
GenEMBL XP_750862.1 also EAL88824.1
GenPept AAW03300.1 GliF
Gardiner,D.M. and Howlett,B.J.
Bioinformatic and expression analysis
of the putative gliotoxin
biosynthetic gene cluster of Aspergillus fumigatus
FEMS
Microbiol. Lett. 248 (2), 241-248 (2005)
MDQVYLPQSVRTAVAVSFGVGLLYWVYRLLLQKTKSLKALDLPVLQSVGDQDIVKTLEEGHAKYPDTPFA
LGVPGQQLVVLPVSEIDTVKALPENQLSIKKHHYNQFLGEYSYMGTKADEFDDAMRYLLVRNTPAVLASF
TAEIDYAMSTVLQVPPNSWTRVKPRSIMPKVATILSGRAFVGLPLSREPDWIESNVNYTQDVSRAWMVLR
FYPHWIRPLVAPFLREVKTLEQNKALIGRKIAKLLADQEAQKLSPAQEKIPGGDMIDWFKSRYQAQGKTA
TAQQLTRDQLLATFASIYNLSNALTYVMFDLAANPAAVDELREELDQVLGPNVGAESIDKTALPRLIKLD
SFVRESQRLSPTSLVNIPRIVTDPNGLRLKTGHVIPPGYLVMVRAQPINQSPTLYPNPERFDAFRFARLR
QQGGANENRWQHTSTGADNINFGHGIWACPGRFFASAEIKVVVAYVIRHYDLRLIEGRPHPKPKYGGLAI
FPDAGAEVELKPRV
>CYP5085A1 Neosartorya fischeri
96% to CYP5085A1 Aspergillus fumigatus = ortholog
NFIA_055420
MDQVYLPQSLRTAVAVSFGVGLLYWVYRLLLQKTKSLKALDLPVLQSVGDQDIVKTLEDGHAKYPDTPFALGVPGQQVVV
LPVSEIDTVKALPENQLSIKKHHYNQFLGEYSYMGTKADEFDDAMRYLLVRNTPAVLASFTAEIDYAMSTVLQVPPNTWT
RVKPRSIMPKVATILSGRAFVGLPLSREPDWIESNVNYTQDVSRAWMVLRFYPHWIRPLVAPFLREVKTLEQNKALIGRK
IAKLLADQEAQKLSPAKEKVPGGDMIDWFKSRYQTQGKTATAQQLTRDQLLATFASIYNLSNALTYVIFDLAAYPAVVDE
LREELDQVLGPNVGAESIDKTALPRLIKLDSFVRESQRLSPTSLVNIPRVVTDPNGLRLKTGHVIPPGYLVMVRAQPINQ
NSTLYPNPERFDAFRFARLRQQGGANENRWQHTSTGADNINFGHGIWACPGRFFASAEIKVVVAYVIRHYDLRLVEGRPH
PKPKYGGLAIFPDAEAEVEFRPRV*
>CYP5085A2 Fusarium verticillioides
53% to CYP5085B1 Mycosphaerella graminicola
54% to CYP5085A1 Aspergillus
fumigatus
not found in the F. oxysporum genome
FVEG_13316
MGLVQHLTSQAAKQ
QHMPFHYGIALLLVLTYGLYRMIQPKKKHNLPVFRLRDNNVLAVLTEAYKQVRHS
(0)
YPTSAFMLELPGMEMAVLPPADVDTIRGLPESVVSIK (2)
KHHYDVFLGEYTYMGTKSDEFDSAMRNVLTRNTPAVLESFTDEVEYAIFNTIGPCKD
WTPIVARKAMCKVASLMSGRAFVGLPLSREPDWVEANVNYTADVSKAWMILKMIPQPIR
FFVAPFLPQVRSLKRQRKNNEAKLAPLLREKQDSSSATSASKEKPVGGDLLDWFISQYKT
TTTVQELGRDQLLATFASIYNLSNALTYIAFDLAATPEEDVEE
MRKELTEVLGEDGVIDKNSLAKLKKLDSFAKESQRLCPPSLVNIPRIVTSPEG
LKTSTGDVLPTGTRMTIMSHFINHDPKVYPDPEKFDPFRFSRLRQVP
GNETKYQHASTGLDNINFGHGIWACPGRFFASAQIKVVLAHLLKNYHVK
LKKGTDKPGQIHYGLAILPDAQAEIMFKSRK
>CYP5085B1 Mgr058 Mycosphaerella graminicola
51% to CYP5085A1 Aspergillus
fumigatus
MPIIHHIKDTPRGFIAGAFILFVTARLVWLVTARARRADRPSKFAVFQGETDVIQTMEEANEKLPETPFVLSMHGMQVFV
LPRSEIETVKSLPECEVSIKKHHFNVFLGEYTFMGTKADEFDDTMRYTLTRSTPTALDAFTDEIGYAMDQCIGQCDDVWT
GIRIRAAMARIASLLSGRVFVGLPLSRDPEWVEATTQYTQNVTTAWMILRLIPRFIRPLVATFLPQVRTLKRFRRATVEK
LSPILAAKRQGIHSKTTSDPAGGSMLEWLTAHYKVQPTAEQLARDELLVTFASIYNLTNAISSMVFDLAKYPEHIPE
LRQ
ELAEVLGPSGIIDKHALSRLRKCDSFIRESQRLSPPSLANIPRIVTNPHGFVTSTGHRIPAGSTVMIRAHPINRDRKLWG
DNADQFDGFRFSKLRDMPGNALKYQHTSTGTDNINFGHGIWACPGRFFASAQLKVILAELLRRYDIMRSPQTPNPGQLHY
GLAVVPDPEAEVLFRKRM
>CYP5085B2 Aspergillus terreus
55% to CYP5085B1
ATEG_03471.1
MSLASLDLNALWLEHSAVIATLFAFGTALFLVSRSQKQSLNLPRFEVTNDVLKTIEEAHAQYPDDPFILSMVGMELAILP
RSGIDVIKTLPEDQVSIKRHHHDVFLGEYTYMGTKSPEFDEAMRYDLTRNTPTVLASFVAEVQYAVEDSFGRPDQWTAFQ
PRACMSKIASLMSGRAFVGLPLSRDNTWVDATVRYTQDVTRAWLVLRTIPWVLRPFVAPFLPQVRSLKNQRRMTEERLTP
LLDPSNAKNRDEIPGGDMLRWFRQRYPQGPTPKQLARDQLLATFASIYNLSNALSYLLFDLATYPEHIEPLRQELQEVLK
GEPVNKENIQKLKKLDSFIRESQRLSPPSLANMPRIVTNPRGLKLPSGHTIPCGMRIMVRAHTLNLDPNLWPNPTRFDGF
RFSKLREIPGNTFKYQHATTGTDNINFGHGLWACPGRHFASSQMKVVLAHLLLNYDIKLPNRMEKPQQQHFGLAIVPDTE
QMVLLKIRG*
>CYP5086A1P Aspergillus fumigatus Af293
GenEMBL XP_749878.1 also EAL87840.1
missing first half of gene
54% to 5086B1
note the end of CYP65AA1 is only 11 bp from
the stop codon
on the opposite strand
FLRPLVYRLIPDVQRVYQHNARARQLVGSIVKQREKDEATIPGYTKPNDAIEWIW
DLVPNEDKKNYGYQGIAQLAIAAVSVRRTSQLLTNIVLNLIAYPEYVPILKEEIENVLAS
CDGQWTLDSMSKLEKLDSFMKESLRFDTPLT (1)
ATFQRKAVQRITLSDGTVLQPGTLALAPCNAIAFDPNIYPNPEQFDELRFYKLRHQNDSK
ANNIIYFTAASKTQVQFGGGRHACPGRWFAAHLIKMVLA &
AILFKYDLKFRTGEERPKTWLFQTINTPDPKGKILVRTAQHV*
>CYP5086A1 Aspergillus clavatus
54% to
CYP5086A1, 38% to CYP602B1
ACLA_055780
MSFELTLEHAIRLLHSSLTLLTSLVGFIAIVAFATQRSPEISSAPLFTPTKSAAGNRKRRWMYDSVNLLQEGYKMFQGKP
FQIWTTEGAQVVIPPDFVDELKMLPDHTFPSALRHFFLHKYLWPIDQHKLDYGHVVIKNDLNKSMSRVFPELCDEVDAVF
PLEFPEFKGWTPIQVYPKMLRLVSRINGKIFVGPSLYDNEEWITISCNYTKNLFLSSAKLRFFHPWLRPMAQFFIPELRA
VWKCNERAQALLTPVLHQRQAQEASASKGGGGEYKKPNDSIEWLRDLVPGPDKNDPLFHAISQLGIGAVSVNTTCQLLTN
SLFNLAAYPEYLPMLREEIESVWAANNQHWTLASMGQLKRLDSFIKETLRFNGHLTATFQRVALRPITLSDGTTIPPGTY
TFAPTNAVNFDSEVYPDPEAFDGLRFYKLRQASSANESKYQLTSITKTELQFGSGRHACPGRWFASHEIKLVLAAVIRRF
DLRLKGEERPKGMLFQTNQLPDVKAEILFKERRM*
>CYP5087A1 Aspergillus fumigatus Af293
GenEMBL XP_748328.1 also EAL86290.1, AAHF01000011.1
alkane
hydroxylase predicted
missing C-term
MYTALGLAVFTALFHYTIVLAINHYRTREILSQLVKAHNCCPPKTERPWDILGLVKIYSSTKHLLNETAL
SNVSALFKCYGDTYASRILTQRVYFTCDPRNIRHVLINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWK
EARSLYADIFSATRKIFDLQLQEDGFQGLIKQIPRGQAMDLAPLFLKLVLDVNSAFAMGTGLDTLKQDQS
LEKKEVAEALMYAKKIMARDGFLGPLHYLLSRKDFYAACETVKAYVEKVVRKEMTAREYQKQSNAATVDD
ERQKRTQSLLSRILDNTNDVHAVRDAVVTILIAGTDSVASMLSTTFYLLARHERVYAKLRQEILDTIGTE
PPTYDNIRKATYLRYVFNEAMRVYPPVPFNARTANRDTYLPAGGGPDGQSGVLIRKGQRVIFASWGSHRS
TRSFGADALEFRPERWEGLK SESLGYIPFSAGPRVCLG (1)
QQYALLEASYATIRIIQT
FERLENRDVRPWTEKIGLNLSNKNGVLVELVH*
1196659
>CYP5087A2 Aspergillus clavatus
94% to CYP5087A1
ACLA_024290
one frameshift, probable seq error
AAKD03000001.1
MYTALYLAVFIAVFHYTIVLAINHHRTRKTLSQLVKAHNCSSPKTERPWDILGLIKIYSSTKHLLNETALSNVSALFVRY
GDTYASRILTQRVYFTCDPRNIRHILINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWKEARSLYADIFSATRKIFDLQ
LQEDGFQGLIKQIPRGQAVDLAPVFLKLVLDVNSAFAMGTGLETLNQDQSPEKKEVAEALMYAKKIMARDGFLGPLHYLL
SRKDFYAACETVKVYVEKVVRKEMAAREYRKQSNAATVDDERQKRTQSLLSRILDHTNDVPAIRDAVVTILIAGTDSVAS
MLSTTFFLLARHERVYAKLRQEILDTIGTEPPTYDTIRKATYLRYVFNEAMRVYPPVPFNARTANRDTYLPAGGGPDGQS
GVLIRKGQRVIFASWGSHRSTRSFGADALEFRPERWEGLKSESLGYIPFSAGPRVCLG
(1)
1818655 QQYALLEASYATIRIIQT & 1818708
1818708 FERLENRDVRPWMEKIGLNLSNKNGVLVELVR*
>CYP5087B1 Aspergillus oryzae
GenEMBL BAE63940.1
41% to
CYP5087A1
MSPRGKMVQPIETPRQAFLAHPLTVILVGIILSLLVRRLLWNLKQRELERLHGCERLHNEGGCLRYDFLG
IAKAIKLGFHFRRRTSLPYTNALFKRYGETYASNVLGYRLIFTCSAENIKHLLSTAFADFDSSPLRKPLF
QPITPDGIFTLDGPGWKKSRDQLRSRLSNLRKIVDLNQCERHFQAFLQHVPPNGQAFDVQACAFALALDM
QTLFSLGESVDALSFCQSREKKQFLEDLLFVKEKIVQDGFRGPLRYLYPKRRFLHCCKRARRYVIAHVSR
QLTGCSSMSEKAEGAQPTNAEEE
VSLLADQALSILLANDSMSTTLSGLFFCLSQDERVVKKLTASILDTV
GLEPPTWGQLGTLHYVRWVLQE AMRLFPA VVFNARVANKNSTLPTGGGTNGNSPVLIRKGEIVVFSTWAR
HRLGKDFGENPDEFYPERWEHLSGDMIGFIPFNKGPRACPGQH
YAMIVLTYIVARIFQTFSTVSNYDTRE
WTERISMTLENENRVLIGLS
>CYP5087B1 Aspergillus flavus
99% to CYP5087B1 Aspergillus oryzae
AFL2G_08921 revised
MVQPIETPRQAFLAHPLTVILVGIILSLLVRRLLWNLKQRELERLHGCERLHNEGGCLRYDFLGIAKAIKLGFHFRRRTS
LPYTNALFKRYGETYASNVLGYRLIFTCSAENIKHLLSTAFADFDSSPLRKPLFQPITPDGIFTLDGPGWKKSRDQLRSR
LSNLRKIVDLNQCERHFQAFLQHVPPNGQAFDVQACAFALALDMQTLFSLGESVDALSFCQSREKKQFLEDLLFVKEKIV
QDGFRGPLRYLYPKRRFLHCCKRARRYVIAHVSRQLTGCSSMSEKAEGAQPTNAEEEVSLLADQALSILLANDSMSTTLS
GLFFCLSQDERVVKKLTASILDTVGLEPPTWGQLGSLHYVRWVLQEAMRLFPAVVFNARVANKNSTLPTGGGTNGNSPVLIRKGEIV
VFSTWARHRLGKDFGENPDEFYPERWEHLSGDMIGFIPFNKGPRACPGQHYAMIVLTYIVARIFQTFSTVSNYDTREWTE
RISMTLENENRVLIGLS*
>CYP5087B2 Aspergillus niger
e_gw1.3.514.1|Aspni1
71% to CYP5087B1
MTALLLSGPSKSNGLLLALAVIAVGVAITLLANNFNQRRRSRQLEQLHGCEKPPNESDRFRYDIFGIAKSIELAYHFRRR
TSLSYTNALFKRYGETYASNVLGFRLLFTCNADNIKHLLSAAFIDFDSSPLRRPLFEPITPHGIFTLDGAAWKTSREQLR
SRLSNLRKAIDLSLCEQHFQDFLRHIPLNGRPFDIQSCAFGLSLDMQTLFSLGESVDALSFTQSQEKKQFFKDLLLVKNR
IVQDGFRGPLRHLVPKRSFLQACKSSRAYVMARVVRDLERQGSVDKEADELPTLESYSDTNRVSQLTDQALSILLANDSM
STTLSGLFYCLAQNERVVHKLRASIIDAIGLTPPTWGQLGTLHYVRWVLQEAMRLFPPVVLNARVANKESTLPTGGGAHG
DKPVLVMKGDIVVFSTWARHRLGKDFGEDPEEFRPERWEQLSGDMAGYIPFNKGPRICPGRK
>CYP5089A1 Aspergillus fumigatus
GenEMBL XP_752692.1 also
CAF32039.1
MVDVFVLRQLGVRDMVTLNCRMADERQGITDAINVSQSSQCTDLVGFQVGPCHLFSSRWHSGSDLSAER
TSIPRDIMSLAIILFALTLAAFIARVVYRCYFHPLARYPGPW
FAHISNAW RLVAFFSGQHHLMEQRLHARY
GRVVRVAPNWLSFSTLEDFEAIYGFNKAIEKDEFYDFGRDRGSRPESIFAAKTETSHRVKKKKVVSPALT
STRITSYKPIIDKHVGILLTRLPSQSKGPLPEAKNNGTTAVNMAPIVHQCTLDAMLELVFGPRLSEHPYS
DTPAGEGVCSNLRIMTKMAWSFSLWPAFGWLMNTRPVNAMLRRPTYSKQGELTGMAGLMGVAMPRLLRNP
QQVVASSQPSIVKGWLEVPPDDATRMTPAEVASEASNLIIAGPGSTAAALTAVIFYLGTKDGQGWQERIR
EQIRASQSHDLGPSSLELQAVIKETLRLSAPFPTAFPRVIRPGAEMAIPSLAAPLPVGTTVSANTFVLGR
SRELWGNDADRWEPRRWLGSEQHRREMETKFVAFSKGSRSCIGRELALLLLAQAVIGIVQQWKFRSRGQL
QGKSFLEMQYDECWIKFEPLDLSLSA
>CYP5089A1P Neosartorya fischeri
91% to CYP5089A1 Aspergillus fumigatus = ortholog
NFIA_012290 REVISED
VLRQLGLRYMVTLNCRMTDERQ &
GQRDAINVSQS &
SRCTDLVGFQSA (?)
PRHLFSSRWHLGSYLSVES
TSIPRDTMSLAMILVALTLAAFIARVVYRCYFHPLARYPGPWFAHISNAW (2)
RLVTFFSGQHHLIEQRLHARYGRVVRVAPNWLSFSSLDDF
EAIYGFNKAIEKDEFYDFGRDRGSRPESIFAAKTETSHRVKKKKVVSPALTSTRIASYKPVIDKHVGILLARLQSQSKGP
LLDAKNDGTTAVNMAPIVHQFTLDTMLELVFGPRLSAHPYTDTPAGEGVCSNLRIMTKMAWSFSLWPAFGWLMNTRPVDA
ILRRPTYSKQGELTGMAGLMGVAMPRLLRNPKQVIASSQPSIVKGWLEVPTDDANRMTSAEVASEASNLIIAGPGSTAAA
LTAVIFYLGTKDGQAWQERIREQIRASQSHDLGPSSPELQAVIKETLRLSAPFPTAFPRVIRPGAEMAIPSLRAPLPVGT
TVSANTFVLGRSRELWGNDSDEWEPRRWLGSEQHRREMETKFVAFSKGSRSCIGRELALLVLAQAVIGIVQQWKFRSRGE
LRGNSFLEMQYDECWIEFERLDLSLSE*
>CYP5089A2 Aspergillus oryzae
GenEMBL BAE60720.1
57% to
CYP5089A1
MVSSTAFIVVQVALAALAAHVIYQCYFHPLARYPGPFLARFTNLWRLFTFFGGQHHLSEQHLHDKYGHVV
RVAPNWLSFSDLHDFDAIYGFNKSVEKDDFYLFGRPRDNRVPSVFALKTDADHRQRKRKVVGPALTTAKI
TRYESVVTKHVDLFFTRADAASASRQDGEMAAVNLAPLAHRFTMDVMLELIYGPDVVSHPYTDSATGADM
CSAMRKLVKMAWSFSLCPSYGWIMNSRLISGVLRTLTTSKQGGPTGMMALMTSSHTMIFRRPEQVSLPGQ
PGIVKSWLDIPLDDSSRMTQDEVFSEAVNLVFAGPGSVAAALTAMVYQLGTQEGQLWQEKLRKEADVEAP
PFSLELQAVVKETLRHCASFPTAFPRVIRRGAETIVSTLPAPLPIGTTVSANSYILGRSRKIWGHDADQW
LPQRWLGDESQRREMEAKLVAFSKG SRGCVGKELAWLVLAKAVMAIIRRWKFVSVGELRGKSYLEMQYDD
CWIEYEELA
>CYP5089A2 Aspergillus flavus
99% to CYP5089A2 Aspergillus oryzae
AFL2G_03453
MVSSTAFIVVQVALAALAAHVIYQCYFHPLARYPGPFLARFTNLWRLFTFFGGQHHLSEQHLHDKYGHVVRVAPNWLSFS
DLHDFDAIYGFNKSVEKDDFYLFGRPRDNRVPSVFALKTDADHRQRKRKVVGPALTTAKITRYESVVTKHVDLFFTRADA
ASASRQDGEMAAVNLAPLAHRFTMDVMLELIYGPDVVSHPYTDSATGADMCSAMRKLVKMAWSFSLCPSYGWIMNSRLIS
GVLRTLTTSKQGGPTGMMALMTSSHTMIFRRPEQVSLPAQPGIVKSWLDIPLDDSSRMTQDEVFSEAVNLVFAGPGSVAA
ALTAMVYQLGTQEGQLWQEKLRKEADVEAPPFSLELQAVVKETLRHCASFPTAFPRVIRRGAETIVSTLPAPLPIGTTVS
ANSYVLRRSRKIWGHDADQWLPQRWLGDESQRQEMEAKLVAFSK (1)
GSRGCVGKELAWLVLAKAVMAIIRRWKFVSVGELRGKSYLEMQYDDCWIEYEELA*
>CYP5089A3 Aspergillus niger
e_gw1.3.357.1|Aspni1
57% to CYP5089A2
MASLIVVIAQLTVLTLASRMVYLCYFHPLAPYPGPFWARCTNLWRFFTFMTGRLHLAEQQLHQKFGPVVRVAPNWLSFSS
LEDFDAIYGFNKSVEKGDFYAFGRSPSQREASIFSTKSDTIHRHKKRKVLGPALSSSKVARYEPVIEEHVAILLARLEAS
RQPAGTAIATANVAPLISRFTLDTMLEILFGSAIASNPYTDSAAAGAICSQLRKMTKRAWSYSLWPIYGRIMNSWAINYL
LRSLFYNGDGAQTGMTGLAAAVHRAIMRDPQHVMQSPKPGIVKSWLEVPVDDVNRMKQPEVLAEAMNMVFAGPGSMAAAL
TAIVYHLGSEEGQVWQDKIRRKGAVSSQSITAATIPLELQAVMKEAMRFQGVFPTAFPRVIMSGAERVIPSLSTPLPVGT
TVSANTYVLSRSREIWGDDADQWIPERWIGDAEHRRQMETKFVAFSKGPRGCVGKDLALIVLAKAVMGLILQWQIISVGS
LRGKSWLEMQYDDCWLELRRLSTAP*
>CYP5089A4 Aspergillus clavatus
71% to CYP5089A1
ACLA_022220
MALATMLLSLALAACIARVVYLCYFHPLARYPGPWFARFTNAWRFVTFFGGQHHLIEQRLHAKYGRVVRVAPNWLSFSSS
DDFEAIYGFNKAIEKSDFYDFGRDRGSRAESIFSTKTEAGHRVRKKKIVGPALTSSKISAYEPVIDKHVDILLLRLQSAD
PLPEPNGHGPLSVNMAPLVHQYTLDSMLELIFGPTLAAHPYTDTPAGDGICRTLRIMTKMAWSFSLWPAFGWLMNTRLVD
AVLRRPTRNKQGVATGMAGLMGAVMPMLQKNPQQVTQSPQPSIVKNWLDIPASDANRMSPGEITADAFNMVIAGPGSTAA
ALTAVLYHLGSQHGQTWQEKIRDETRMPTVSSPALQAVIKETLRFSAAFPTAFPRVIRHGAETAIPGLPAPLPPGTMVSA
NTFVLGRSAEVWGDDAGQWAPQRWLGDEQQRREMEAKFVAFSKGSRSCIGRELALLVLASAVTGVVQRWRIRSQGALRGK
SFLEMQYDECWMELEPVAL*
>CYP5090A1 Aspergillus fumigatus Af293 check
EAL93738, XP_755776.1, NFIA_089610
complement(join(AAHF01000001.1:1906434..1907040
,AAHF01000001.1:1907095..1907853,
AAHF01000001.1:1908125..1908255))
1 mlsdavsaai dwtgqgiswv kqeypaltva vtsacvlvlw
riwr
FTILPSFHPNDPKELPYCIP (1)
WHGAAFFSNSNALLSRAR (2)
nyfnni qdpfalsian
61 sliyvitkpq dvaeayrntd
tlsfnefvqa mmracgntes cvktmykplp kdkpgfpnph
121 gkplatlarq mhihqlypgd nldflekqfl
dwveprltld alrrecpyai qsgppavtkd
181 dgivlplmqw csdyftragq rayfgpaldg
idpklpqtfi vfdelswqvl yqypeflagk
241 mksarnaiqr alkkyiqlpq esrqgdawft
kamenemral giseddiatm lvtiywgint
301 ntrkaafwll tyilhygpeh yvdiirqetl
paflpdksip dlnylhdncp hldamwneti
361 rlsaysasvr fvtsdtiigg kilrkgnrlm
ipyrqlhfde sifgvdypve efrherfmqk
421 grnltrsdnw rpfgggttqc pgryvakrfv
llfvamllrr fdvelvttri paaeegkpvl
481 gimsikdged vlvrvrpr
>CYP5090A1 Neosartorya fischeri NRRL 181
XM_001260900, NFIA_089610
96% to CYP5090A1
Aspergillus fumigatus = ORTHOLOG
MLSDAVSAAIDWTGQGISWVNQEYPALTVAVTSACVLVLWRIWRFTILPSYHPNDPKELPYWIP
(1)
WHGAAFFSNSNALLSRAR (2)
NYYNNIQDPFALTIANSL
IYVITKPQDVAEAYRNTDTLSFNDFVQAMMRACGNTESCVKTMYKPLSKDKPGFPNPH
GKPLATLARQMHIHQLYPGDNLDFLEKQFLDWVEPRLTLDALKRECPYAIQSDLPAGK
KDDGIVLPLMQWCSDYFTRAGQRAYFGPALHGIDPKLPQTFIVFDELSWQVLYQYPEF
LAGEMKSARNAIQRALKKYIQLPQETRQGDAWFTKAMENEMRALGISEDDIATMLVTI
YWGINTNTRKAAFWLLTYILHYGPQHYIDIIRQETLPAFSSDKSIPDLDYLHDNCPHL
DAMWNETIRLSAYSASVRFVTSDTIIGGKILRKGNRLMIPYRQLHFDESIFGVDYPVE
EFRHERFMQKGRNLTRSDNWRPFGGGTTQCPGRYVAKRFVLLFVAMLLRRFDVELVTK
RIPAAEEGKPVLGIMSIKDGEDVLVRVRPR
>CYP5091A1 Aspergillus fumigatus Af293
GenEMBL XP_755777.1
EAL93739
join(AAHF01000001.1:1908934..1909376,
AAHF01000001.1:1909470..1909557,
AAHF01000001.1:1909606..1909750,
AAHF01000001.1:1910034..1910304,
AAHF01000001.1:1910386..1910566)
1908580
MLEILVTFLIFCFRRIRGLWYLARGPEIIDRAYIA 1908684
AEGKPFRIYTPSNDHLLVTSKEHIAELVNAPLQNLSLHAVAKE
(0)
ILQPKYTMFGFEWHNQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGSPQLCLIPSDCS
RLRALQTVPYDQANGHQGQLLRLLRGGTWYDYPWHVRHRQAHCVAAQNPEFTAAALEFPQRVILAAEILR
ITPSFLR
(2)
RTLFRYLKPIVEKRLAARANSPRSLQEDAP (0)
MDCMQWLIDTSPRKIPWTPTRMVGEIVAVWFGS
VHQLAM (0) 1909749
1909815
TTTYAIEDLCLHSDYVEPLRAEIQQYLEGPCRRRVAEMPLLDSFVRESIRCTNSDA (1) 1909961
1910033
LTVRRKALTPFMFSDGLEVAEGDWVCIPQRAMMRDRIRYQNPQAFDGFRFARANK
QLRAGDVSLDVPENSPLTMTDVSVDWPIWGLGKTAC (2)
PGRFYAATILKLIMVCILEKWECRLENPKSQRWR
TWRSSVVPREGTVVMFRRKEEALTG
>CYP5091A1 Neosartorya fischeri NRRL 181
GenEMBL NW_001509762.1
Also called CYP5126A1
ortholog, 92% to A. fumigatus XP_755777 revised
MLEILVTFLIFCFRRIRGLWYLARGPEIIDKAYIA (0)
AEGKPFKISTPSNDHLLVTSNEHIAELVNAPLQNLSLHAVAKE
(0)
ILQPKYTMFGFEWQDQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGPP 530
531
QSCLIPSDCSRIRALQIVLYDQANGHQGQQLCLLRGGTWYDYPWHVRHRQAYCVAAQNPE 710
711
FTAAALEFPQRVILAAEILRITPGFLR
794
5164664
RTLFRYLEPVVEKRLATRANSTRSMQEDAP (0)
MDCMQWLIDTSPRK 5164843
5164844
IQWTTTRMVGEIIAVWFGSVHQLAM
(0)
TTTYAIEDLCLHSDYVEPLRAEVQQYLAGSCRRRVAEMPLLDSFVRESIRCTNSDA
(1)
ITVRRKALTPFVFSNGLEVAEGNWVCIPQRAMMRDRIRYRNPQAFDGFRFARANK
QLRA 5165393
1626 GDVSLDVPENSPLTMTDVSVDWPIWGLGNTAS (2)
PG 1806
RFYAATILKLIMVCILEKWECRLEDPKSQRWRTWRSSIVPREGTVVLFKRKEEALTG 1976
>CYP5092A1 EAL94097 Aspergillus fumigatus
Af293
EAL94097 XP_756135
complement(join(2910619..2911240,2911273..2911511,
2911803..2911958))
84 kb from pksb too far to be in the gene
cluster
1 MLLLTFTLPV VTLLLAHIIR SWFRLRHIPG PFWAKITDLW
REHHYIKGDY GDRPMAPYFA
61 IPSLLGMESA MDQIQQELED QICRRVTIDV VLWMRLFSLE
SLHWIAFSNK LGYLSEGKDT
121 DGILSILQSK FIGLAGQLCG WIHRTTLRFH
FPKSCTGTAV APSQRKASHR DLLAHFMDAS
181 QKNPETLEER GVLGATISTI FAGTDTTGTS
LTFFMYYLIK HPAALARLQE ELDSAVRSGN
241 LSYPPKWVEV STLKYLQAVF KETLRLHSTA
RMSLYRVVGP EGLDLCGERL PSGTNLGCFG
301 YTAHRNEPIY GRDAALFRPE RWIEASNDTL LSMERASL
>CYP5092A2P Aspergillus niger
fgenesh1_pg.C_scaffold_3000010|Aspni1
41% to CYP5092A1 aa 241-396
MAKQAPEEYNQVGVLGATLTIIGAGSGTTEYLLAFLLRSI
V*CPRIKQRLRNELRLAISEGRLPQLPEWAEVSKLQYLGTIVREGLRL
HTPVQSTMNRVIGPGGLDLCSRWIHAGTTVGCFLQAFHLNKDVYGTDAREFGPKRWVEVLEEHVKSMERGGFWFGSGKHV
CLGQHVARMGITKLVASIFMRLENALFMMIGPKKVPEVSPGASLQMSPSVSSRLW*
>CYP5093A1 Leptosphaeria maculans
GenEMBL AY553235.1
sirodesmin biosynthetic gene cluster, SirB gene
note:
a second P450 SirC exists in this gene cluster
Sir C
= CYP5082B1
MSTLQDFQIAPAILHRVTVRDASAILFCTLLTVFLFISQGTVRG
VKRVGKSRLRTLVTGETPLRFDLEKYGYLGYQQFSKKANKPFLVKIYGLDHYVLPVKY
LDSLKTVDHHRLSFAQSLNDF ()
26242 LNVDASLGDLVTHSDMEIAVVTKHLNPRL ()
TTLTPVLVDEANFAFEKELGKLE ()
TWKTVNALFLSAFLTNRTSGRVLVGDLCRDDNYLHAMMKYTES
VFSSGVAFNGIPLGPFRKIVYYLGARQHRRDLDNAAALVLPEIKRRMAAQAEDPNCRK
ENDAIQWNLDLPLASPKEGLPLRHAHRVLHLSFAATGTVAILITHMIYNVLMYPEYLE
PLREEVMACTKAHGGWTEKAMNEMWKLDSFIRETLRVQPPSVFTAYRTVKNQPFTFPD
GFTLPVGSRITFPTLPVGLDPENYESASEFDGFRFFRKREEARLAKKAYNWGATKIDS
SFLPFGYGNQACPGRFFGVRKTKILFGKLINDYDFSWAEPRSARPENIVIEGQILVNP
TPEIKIKSRVAAGM
>CYP5093A2 Aspergillus oryzae
GenEMBL BAE63236.1
75% to
5093A3, 35% to 546B1 Fg, 36% to 546A2 Mg
MDYIHSLPSNPALGLSCCIIFILLAIVLHDVYMWKCLPPGPPPIPLIGNKFQIPSKHPWIKFEEWSNVYG
PIYTIWLGRRPTVVISDPSIASELLEKRSTKYSTRPRFVT MGEIYWDMASILVQPYGKEWLIRRRLLHSA
LTPRALDNYTPLQEAESSRLCYQLLESAHEWEPLFDRLASSIVFAVSYGHRVDSAQSPVIKQRLDFMQYA
SSLNVPGAHLVESFPVLKHLPDWIAPWKAEIKRRGRLEAEANMTLVRVVQQDVESAKESPGAEPLFNSLT
KQLLETRDSDPTAFPLSERDFSYIPASLFGAGSDTTSSTLCSAMLAIVTNPRTMEVAQLELDSVVGRDRL
PTFEDIPNLPYLRAFSKEVLRWRPVAVLGGTPHACSEDDYYRGYYIPQGTVMLGNSWAINMNPKYYPNPD
QFNPLRFLDMDPHLLPYLPKEYTASAEQEKGSGHPSKLGHSSFGWGRRICPGADLATNTLLITLSRLLWC
FDIRPIPGQTYDTLDYTNGFNIRPRSLHLSLQVRSDQHRQVIERGYEVATKFLERLSPFDERMQGNS
>CYP5093A2 Aspergillus flavus
98% to CYP5093A2 Aspergillus oryzae
AFL2G_08665
MDYIHSLPSNPALGLSCCIIFILLAIVLHDVYMWKCLPPGPPPIPLIGNKFQIPSKHPWIKFEEWSNVYG
PIYTIWLGRRPTVVISDPSIASELLEKRSTKYSTRPRFVT
MGEIYWDMASILVQPYGKEWLIRRRLLHSALTPRALDNYKPLQEAESSRLCYQLLESAHEWEPLFDRLASSIVFAVSYGH
RVDSAQSPVIKQRLDFMQYASSLNVPGAYLVESFPVLKHLPDWIAPWKAEIKRRGRLEAEANMTLVRVVQQDVESAKESP
GAEPLFNSLTKQLLETRDSDPTAFPLSERDFSYIPASLFGAGSDTTSSTLCSAMLAIVTNPRTMEVAQLELDSVVGRDRL
PTFEDIPSLPYLRAFSKEVLRWRPVAVLGGTPHACSEDDYYRGYYIPQGTVMLGNSWAINMNPKYYPNPDQFNPLRFLDM
DPHLLPYLPKEYTASAEQEKGSGHPSKLGHSSFGWGRRICPGADLATNTLLITLSRLLWCFDIRPIPGQTYDTLDYTNGF
NIRPRNLHLSLQVRSDQHRRVLEREYEVATKFLERLSPFDERMLQGNS*
>CYP5093A3 Aspergillus terreus NIH2624
GenEMBL AAJN01000232.1
75% to
5093A2 no introns, 36% to 546B1, 35% to 546A2
ATEG_09500.1
49905
MEHLRTLLSSTLVWGAGCGILLIVLGILVHDVILWKRLPPGPPPFPLIGNKLHVPSKHPW 49726
49725
IRFRDWSKIYGPIYTIWFGRRPTVVISDPTVAAELLEKRSTKYSTRPRFVTMGEIYWDMA 49546
49545
SILVQPYGKEWLVRRKLLHSALTPRALDNYKPLQQAESARLCYQLLQHADRWEALFDRLT 49366
49365
ASIVFAIAYGHRVDDFRSPVVRQRLEFMQYSSSLNVPGAYLVESFPILKDLPDWMAPWKA 49186
49185
EIKRRGRIEAEANMNLVRVVQRDIESANEAPGTAHIFNSLTKQLLEIRGQDPASFPLTDR 49006
49005
DFSYIPASLFGAGSDTTASTLCSAMLAIVTTPMVLEMAQAELDSVVGYDRLPTFEDMRNL 48826
48825
PYLRAFCKEVLRWRPVAVLGGTPHACSEDDFYNGYYIPKGTVILGNSWAINLNPEYYPNP 48646
48645
DHFNPLRFLDVEPHSLSYLSEQYLSSTKQEKGTSHPSKLGHSSFGWGRRICPGADLATNT 48466
48465
LLITLSRLLWCFDIRPVPGRTYDTLDYSSGFNIRPRNLHVKIKVRSDHHGGVVEREYGDA 48286
48285
SEFLETLPPFEDSLPEHSPIKM* 48217
>CYP5093A4 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000340.1
60% to 5093A2, no introns,
39% to 546A2, 37% to 546B1
MPLESVFKL
211788
PAYIWASLIFAIPLVALLHDVWVWFRMPPGPTPIPFLGNKHQLPKSKPWIQFQEWSKTYG 211967
211968
PIFTIWIGRKPTIVISDPIIAVDLMEKRSTKYSSRPRMVAMGEILWDGASILVQPYGKEW 212147
212148
STRRKLLHQALTPKALRLYKPVQTAEASRLCSQLLETPANWEKLLERFTSSIVFSVAYGH 212327
212328
RIDSLNADVIYQRFKFMHVAASLNVPGKYQVESFPILKHVPDVLAPWKAKIKAQGREEAA 212507
212508
ANMALVDVVRNDMARAKTRGEDIPDSLCKLLLEMKETEHIPLSDRDFSYIPASLFG 212675
212676
AGSDTTASTLCTAFLALVTHPETLQAAHSELDAVVGTNRSPTFDDEKDLPYLRALVKEVL 212855
212856
RWRPVAVLGGTPHASTEDDYYEGYYIPAGTTVLGNSWAINLNEEYYPNPHLFDPMRFLDS 213035
213036
ALSEKLKAPTGLTGKAHPAKTGHSSFGWGRRICPGAGLAENSLIIALAKILWT 213194
213195
FDILPVKGVKYDTFAYTEGFNIRPKSFRCEIRIRSEVHRKVLEEDFKSAEGVLERFTPFG 213374
213375
E* 213380
>CYP5093A5 Mycosphaerella fijiensis
66% to CYP5093A4 Phaeosphaeria nodorum
e_gw1.21.282.1
MAFTTFLPTLSAHPVLLLLTIVVVIPTFILLHDVLTWLRLPPGPTPLPFLGNKFQIPSSKPWIQFEQWSRIYGPVFTLWI
GRKPTLIISDPQIAVDLMEKRSNKYSSRPRMVVMGEVYNGNSSVLTQPYGKAWSTRRRLLHQALKPVALRLYKPTQEAEA
VRLCNALLRNPDRWEKELERFTSSVVFCVAYGHRIDSLQAKVIADRFKFMHFQASLNVPGKYLAESFPLLAKLPNWIATW
KKEVQEMGNKEGEANMALLNLVKQDIAVAKARGDTVPDSLSKFLLALREKEDIPLSELHFSYVPASLFGAGSDTTASTLC
SAFLALVTNPSVLKAAQAEVDAVIGSQRTPTFEDEVNLPYMRALCKETLRWRPVAVLGGTPHASTEADVYEGYRIPADTT
ILGNNWAINLNEEYYPNPHHFDPVRFLSAYLGSKRHPAPSGHSSFGWGRRICPGADLASSSLFIALAKLLWAYDILPIAG
RQYDIFDYTEGFNVRPKKFEVVIRVRSERHRDVLEREQVLAEKYLEKFTAFGE*
>CYP5093B1 Aspergillus oryzae
GenEMBL BAE56598.1, AP007154.1
45% to
CYP5093A1, gc boundary at GSCE
83% to
CYP5093B2
81343
MASESSIPLYDCLIIGGGIAGLSSALSLVRTLHTAVVFDEGIHRNDQAPHLATVPTWDSQDPKRFRDAAK
LNILSKYSTVEFANVKLEK FNKALGKPFLTKVFGHDYVVLPSKYFDDIKRASPQSLSFFQALSDGLNMEA
SVGHLYASTTEIDVVVKHLNPRLTQLTPLLCDEAEYAIEREVGALPDWKKFNVSNLIAAIVHRTTNRILV
GKELCRNEEYLAITTKFSRSLFISGIFWNFVRLGPLRKLVAWLTIGLHLRDRNAAAKVLLPHVLARRQEK
EAGVDVATKYPDALQWTIDTAPSFPGDDEPLHQVYHMLHLTFAASSASGVGVTQCLLNVLAYPEYLEPLR
DEISTVVARHGGWTDKALSQMALLDSFIRETMRLHPAGS (1)
LTVARTVMDDHFRFHDGLTLPKGTNIIAPALAIHYDP
DNYEDAHRFDGFRFARYRQKQGENHRWLASTIDQKFLQ FGYGNHACPGRFYAIRKIKLVLAKLIMDYDFK
WAQPRPVHDRPEDFAIEAQLVAAPDAEILIRSRNLSN 78253
>CYP5093B1 Aspergillus flavus
99% to CYP5093B1 Aspergillus oryzae
AFL2G_07281 revised
MASESSIPLYDCLIIGGGIAGLSSALSLVRTLHTAVVFDEGIHRNDQAPHLATVPTWDSQDPKRFRDAAKLNILSKYSTV
EFANVKLEKFNKALGKPFLTKVFGHDYVVLPSKYFDDIKRASPQSLSFFQALSDGLNMEASVGHLYASTTEIDVVVKHLNPRL
TQLTPLLCDEAEYAIEREVGALPDWKKFNVSNLIAAIVHRTTNRILVGKKLCRNEEYLAITTKFSRSLFISGIFWNFVRL
GPLRKLVAWLTIGLHLRDRNAAAKVLLPHVLARRQEKESGVDVATKYPDALQWTIDTAPSFPGDDEPLHQVYHMLHLTFA
ASSASGVGVTQCLLNVLAYPEYLEPLREEISTVVARHGGWTDKALSQMSLLDSFIRETMRLHPAGSLTVARTVMDDHFRF
HDGLTLPKGTNIIAPALAIHYDPDNYEDAHRFDGFRFARYRQKQGENHRWLASTIDQKFLQ
FGYGNHACPGRFYAIRKIKLVLAKLIMDYDFK
WAQPRPVHDRPEDFAIEAQLVAAPDAEILIRSRNLSN
>CYP5093B2 Aspergillus clavatus NRRL 1
GenEMBL
AAKD02000026.1
82% to
CYP5093B1
ACLA_066790
366479
MASEQVPLYDCLIIGGGIAGLSAALSLVRTLHSAVVFDEGLHRNDDSPHLATIPTWDSH 366303
366302
EPKTFREEAKLNILTKYSTVEFADVKLEK (0) 366216
365065
VNKALGKPFITKVFGHDYVVLPSKYLDDIKRASPKSLSFFQALSD 364931
364878
GLNMEASVGHLYASTTEIDVVVKHLNPRL (1)
364727
NKLTPLLFDEAEYAIRKEIGPATEWKSFNVSNLIGAIVHRTGNRILVGPELCRDEAYLAAT 364545
364544
TRFSRSLFLHGIFWNFVRLGPFRKLIARLTIGLHLRDRDAAARMLLPHIHSRRQEKASGV 364365
364364
DVAAKYPDALQWTLETPSSFPGDDDPLHQAYQMLHLTFAASSASGVGVTQCLLNVLAYPE 364185
364184
YLGPLREEIKTVVARHSGWTDKALSQMALLDSFIRETMRLHPAGS (1)
LTVARTVMDDQFRFHDGLTLPKGANIIAPALAIHHDPENYTDGSKFDGFRFARYR 363825
363824
QKQGDSHRWLASTIDPKFLQ (2)
363709
FGYGNHACPGRFYAIRKIKLVLGKLLMDYEFQWATPRSVNSRPEDLAIEAQLMVAPDTE 363533
363532
VLIRSCRA* 363506
>CYP5094A1 Aspergillus oryzae
GenEMBL BAE64919.1, AP007171.1
36% to
681A1 in CYP53 clan part C
14
P450 genes and 2 pseudogenes on this contig
MASLTGAAAVLLAFILAYSTALTIYRLFFHPLARFPGPRLAAATKWYEFYFDIIKSPGGQFFKELSRMHD
VYGPIVRVNPDEIHVRDAAWFEVLYAPNPTKRNKYRPSAEMAGLTLGIHGTVDHDLHRRRRMAIAPMFNK
QSILSAEHLIKQHIDELTDVFESYLGTNNPINLQTTFLAYTTDVLYHYMFDTDAGYQRDSGAAQQWRHSM
DAVAQATPFLKQFPSLLSRVALIPLPMLIWVLKRIQPDVAGLLGTHQLMASIVSKYMASKPEEDQDELIA
TKAVKPRTLFHAIEASSLPPHEKAPTRLAQEGLTVLFAGGETGSRLLAHTVYHLLKNPEILEKVRKEILD
AAGDSNQLPDMKALEALPWLTASVRESLRLRAATTSRLPLVTEKPLAYADWVIPPNTPVSMSHGDILHNE
DIFPDPMKFMPSRWFNASPQQNRLFVPFGKGTRMCVGMNFAYCEIYMSLAVILARFDLELYDTRWERDVH
YTRDCFLGEPDPASPGIRVKVVADHKTFTRS
>CYP5094A2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000032.1
77% to
5094A1, 35% to 681A1
ACLA_064180 revised
260809
MTSSLPIPLQVLNLG
260854
LSFIFAYLTSIIIYRLYFHPLARFPGPKLAAATKWYEFYFDIVKRPGGQFFQELNRMHEIY (1) 261036
GPIVRVNPDEIHIRDPSWFDVLYAPNPTKRNKYWPSAEMAGLTLG (1) 261228
261296
THGTINHDRHRRRRMANAPMFNKRSILSTQGLIKQHIDELVEVFASKSGTDEPVDLQTTFL 261478
261479
AYTTDVIYHYMFDTDAGYQRDPKVARKWRHSMEAVAQATPFLKQFPNLLSNLLRIPLPIL 261658
261659
IWVLKRVQSDVAGLLETHQ (0)
LMAKIVSKYMATKATEAQSETDEE
261838
261839
SKKVKPRTLFHAIERSSLPPDEKQPPRLAQEGLTVLFAGGETGSRFLAHTVYHLLCNPDI 262018
262019
LDKVKKEILDAAGESNEVPDVRTLEGLPWL (0) 262108
262165
TASVRESLRLRAATTSRLPLVVEQEMVYQNWVIPAN (0)
262345
TPISMSHPDILHNDSIFPEPLRFRPARWFTATEQQNRLFVPFGKGTRMCVGMD (2) 262503
262562 FAYSEMYLSLAAILPRFDMELYETDWERDVQYSRDCFLGEPDPRSPGMRVKVVAD 262726
262727
NKAFALTETAMVS* 262738
>CYP5095A1 Aspergillus oryzae
GenEMBL BAE66500.1
44% to
CYP5095B1
41% to
682D2, 36% to 551A1, 34% to 551A2, 38% to 682D1
note 682D1 probably has a
small intron after the KYG
MGFTQDLVSVIRPSIESPLAFCATTVVAVALYVLVLGVYRITLHPLAKFPGPKLAAFTQWYETYYEFFKS
PGGQYLFHYRKLHEKYGPIIRLSPFEIHIQDSSFFEEMYSQSLPWDKPKELEHRFGNANGLFPTHKHEVH
RHRRAALNPYFSKRAINNAVPMMQEQITKLCDRLRREYQGTGKVFRLDWMMGCIASDIIVRYCVDRGYDF
FEAPDFKSPFIQALFDLLDGVHMITQFPWVATLFNSLPQGLVETLQPGMKSVHHFHKEMADQVAHILSNK
EKRNGSEQTNVFNALLDSDLPPEELTLTRLQQEAFTVIGAGFDTTRYALSVAGFHIINTPSIYQRLREEL
KTAIPDPSNMPSLTDLEQLPWLTACIQECVRMSYGVSQRAFRISDHITLTYKNYVIPPGTVVSMDNYSVA
HDEEIFPESFTFKPERWLGDPLAPDGKKLTRYLVSFGKGTRSCLGINLAYAEMYLTIANVFRNFDFELFE
TDRSSVDCYRDMFLPHVKLGSQGVRVKIN
>CYP5095A1 Aspergillus flavus
99% to CYP5095A1 Aspergillus oryzae
AFL2G_11819
MGFTQDLVSVIRPSIESPLAFCATTVVAVVLYVLVLGVYRITLHPLAKFPGPKLAAFTQWYETYYEFFKSPGGQYLFHYR
KLHEKYGPIIRLSPFEIHIQDSSFFEEMYSQSLPWDKPKELEHRFGNANGLFPTHKHEVHRHRRAALNPYFSKRAINNAV
PMMQEQITKLCDRLRREYQGTGKVFRLDWMMGCIASDIIVRYCVDRGYDFFEAPDFKSPFIQALFDLLDGVHMITQFPWV
ATLFNSLPQGLVETLQPGMKSVHHFHKEMADQVAHILSNKEKRNGSEQTNVFNALLDSDLPPEELTLTRLQQEAFTVIGA
GFDTTRYALSVAGFHIINTPSIYQRLREELKTAIPDPNNMPSLTDLEQLPWLTACIQECVRMSYGVSQRAFRISDHITLT
YKNYVIPPGTVVSMDNYSVAHDEEIFPESFTFKPERWLGDPLAPDGKKLTRYLVSFGKGTRSCLGINLAYAEMYLTIANV
FRNFDFELFETDRSSVDCYRDMFLPHVKPGSQGVRVKIN
>CYP5095A2 Aspergillus niger
fgenesh1_pg.C_scaffold_15000164|Aspni1
67% to CYP5095A1
MGLIQGLVAGLSSVADSPIALCAVLTATLIVYSVGLGIYRLTFHPLAKFPGPKLAALTYWYETYYEVFKSPGGQFLFQYH
KLHDKYGPIVRISPNEIHIRDASFFEEMFSNSLPWNKPEHLQYRFDNALGTFSTPKHEAHKPRRAALNPFFSKRAITNAT
PMMQDKLYKLCDRLRREYQGTGKVLRLDWMWGCIASDIIVHYCFNDGYGFINAPDFRSVFIQAMFDLLDMVHVLVQFPWV
GVILNRLPQKFVEAVNPGLKSINHYNREMASQITDILRSKEYGTMKESQRKTVFNALLEGGLPPEELTLRRLREEAFTVI
GAGFETTRYALAVASYHILSTPSIYKRLREELITAIPDPTNFPPLSELEKLPYLTGCLQECIRMSYGIVQRSPRVSDKFP
LIYKTWTIPAGTIISMDNYSVSHDEAIFPDSFTFKPERWLDDPVAPDGRKLTRYLVSFGRGTRSCLGINLAYAEMYISLA
NVYRNFEFELFETSRESVDVYRDMFLPHPKPGTQGVRVKVL*
>CYP5095B1 Aspergillus nidulans FGSC A4
GenEMBL AACD01000118.1
AN10887.3 Resulted from split of AN7082.2
44% to
5095A1, 39% to 682B1
73084
MTMIDLNPDLSFTAKSVALLLFIALGL
73115
LYTTIQVVYRLYLSPLSRFPGPRLAAATGWYEAYFELVHKGGGQFLFEIRRMHEVY (1) 73282
GPIVRINPFELHIADPAYYSTLYTSTLNLDKASHIQHRFNAPTAAF 73474
73475
STPEHALHRRRRAAISPFFAKRRIDEQAPMIQSHVNVICHRLSEEYAGTGKVLCVNELYG 73654
73655
SYVTGVIMTYAFNRCPRFLEEEDFVSAFGKSIQGLKEFVHWAQQFPCLPRILQNVPPVLM 73834
73835
GALFPAMQASLVFQE (0) 73879
73939
EMRMQAHAVLSGHGQKGTIFHDLLASDLPRSELTLPRLKDEAMSIVGAGIETTK 74100
74101
MASVVTTFHILQNPRILQKLQDELDSAIPDPTAPPSLSVLENLPFLAACIKEGIRLGYGA 74280
74281
TGRSPRISRTESLRYGAWSIPVGVMVSMDSYHMHHDESVFPDSYAFVPERWLDGARGPDG 74460
74461
TGSLNKYLASFSRGTRMCVGINLAYAEITIVLARLFRGFVMELYQTTRKDVDCYRDLVGM 74640
74641
EVVRGSRGVRVKVVGRRE* 74697
>CYP5095C1 Mgr004 Mycosphaerella graminicola
42% to CYP5095A2, 39% to 5095A1,
38% to 5095B1, 33% to 682B1
MAFHISTFDYSNPDWAVPLAVSIFFFYIAWPVLYNLVLSPVASIPGPKLAGLTRWVETYHECFNKQGGRFQWAYRQWHDFYGPIIRIAPNEIHIRDSDFYDKLYSHKPQDKTHRLHNRFDSKTSIFDTTHHQLHAKRRAVLEGFFSRKRISEQTPEMQVHLDRLCQIIRNQYLGTGAILSTEDMWSCWTSDIIAAYSFGDDDNLIGLPGFKSPLRDSLNELLEPMHWIVQFPILKRILFSLPQWFVLIINPSIRPVIAMKNGVLRRIQDVRNSVRQSPDGDHADTIFGTIITSDLPTSEGSNERLKDEGIGLLGAGTETTMRTLSLALYYLCEQPAAKAKLLAELKEAIPDPNVIPHWDVLAKLPYLAACLSEAMRLSYGASQRLIRVFDQPVMYGQYVIPAGIEVGMDIWDVCHDESKFPQSHEYRPERWLEDEQLSRYLVVFGRGPRSCIGRQLAYAESCLGLATFVRRFDYELYRTTRVNVAFERDRLAPRPFKGTPGIRMRITGAHE
>CYP5095D1 Mgr072 Mycosphaerella graminicola
41% to CYP5095A1 Aspergillus oryzae, 39% to 5095B1,
35% to 682B1
VLLYRVYFSPLSKFPGPKLAAASSWYEFYYEFIYKGGSQFAFHIDELHQEYGPFVRITPWEIHVNDFRHYDSIYSFQLHH
DKPEHLKWRAGQPNSVFATPDHNLHRRRRAALNPYFSKSRVASFAPYIQERLNSMCQRVQREFAGKEKVLNLGDMWGCLV
ADTIAHYAFHREYNWVNTAVNFQCPLLEQVDVFADIMDTVPHFPVIGMVLYYMPPWLIRIMVPALSGAMDFLNEIESNVN
RIKSPDFKPLQGENQNIMYELYHSDLPDTERRQARLVSEGLGVVSAGLETSKTALERATFRILNDPAVHKRLKDELTATW
PDTKDAAPELSTLEALPYLTACVEEAFRLAYGTPTRLPRVPREPLTLGDRVIPPGYMVATQALTVMHDTEVFPNPMEYIP
ERWMDPVTHPNLKKHLVTFGKGTRVCIGQQMAYAIMTLGIANVVRRFDLTLFETDRSDVDLVRASFKPRPKKGSLGIRAL
VQ
>CYP5095E1 Mgr063 Mycosphaerella graminicola
41% to CYP5095A1 Aspergillus oryzae
(borderline member)
40% to CYP5095A2, 39% to CYP5095B1, 37% to
CYP5095C1 Mgr004
LLVALVLYQIAIVIQRLYFHPLSAFPGPRLAAATYIPEIYYDIFEGEGGQLPFALQRWHKSYGPIIRINPQELHVQDSSWYETLYAPSRPVRKLPNWGHRMKAMESALGASDATTYRKRRTALNPFFTKRKIAEFAPSVQQVCDRIVSRLEREYRGTGRVLNITRAWECMASDIATLSVFGQDPRSVDSPGFCSPTNRATESLVEPIKWFTHLSIIPTLIDRLPEWIVTALMPPAELILRQRKVMELAVVEARAAHSDGKGNDHSLIGSLLQQDLPPEEATLPHFTQEAVIVVGAGGETVARTMTLATFHVLDNPAVQKRLVEELNTAIPDAAEMPDWNVLSALPYLSACIEESLRLTYGVCEKRSRAYDGGDLMYGEWRIPAGTFVGMSNYDVSHDEEIFPDSFSFIPERWLGDPRAPNGKALSRYNVSFGKGMRSCVGMQLAYLELYLGVATFFRSRLASKARLYETNKSDVEMARDCFVPRAAKKSKGVRVIFES
>CYP5095F1 Mycosphaerella fijiensis
45% to CYP5095E1 Mgr063 Mycosphaerella graminicola
e_gw1.7.701.1
MALLTLGNAAAAVLLYLVASFVCRIVYRLYFSPLAKFPGPRLAAATYLPEIYYDLFHGEGGQFPWAIRKWHEQYGPIVRI
NPNELHVKDSSWYDTCYSSTRKSWKHLPVLDAVGMGKSTVAAFNPDRWRIKRNAISPFFSRKNIVAYEPQMHRHMTRVMS
RLQEEYSGTDKVLSLHHFWDCYASDNIMAFAFDQHHDFVNSPNFHSSISEGMDAITEMSNIFKYLTYVPKMMEKLPSWLV
GKLNPAILPVLKVQDDLRTKITDVLSLHDPDRKQSDTIFGSLLHQGLPPEELTHLALHQEAMSVIGAGVETVNRALTIAC
YYIIHDPKIRTRVVSELTEAIPDPSNIPGWDSLQKLPYLTGCIEEALRFTYGVSQRRTRGYRDGPLVYQNWELPPGTWVG
MDNFDVAHDEAIFPDSFAFNPERWMGNPVAADGRPLARYQVAFGGKEQRSCTGIHFAYAEFYIAMAHFFRSPLGGSQAVL
AEGTDEGDVRMTRDTLVPRPRKGRKGVMLVFPSGPVDEKMQS*
>CYP5096A1 Aspergillus oryzae
GenEMBL BAE61439.1
in the
CYP53 clan part C
39% to
682D2 but only 33% to 551A2, 32% TO 5095A1, 36% to 5095B1
MMPTFFQAVCSTCIALAIYTASLAIYRLFLSPLAKFPGPTLAALTGWYEVFFDVLLGGQFMWEIERLHGK
YGPIVRINPHELHIKDPDYYNTLYAGPTRRRDKYLWFLSVGAPTSTFATPESDHHRLRRGMLSPFLSKQA
VRDLEGVIKAKLDLLCEHMKKAMRSGEAVELHAYFVSFAVDVVSTCAFGESGCFEELRRERLDDRWKNVV
TGAFGKLLLTRHFPWLVVVFRFLPVWATALLTPVVRHIDYMEKGVENQMQHVYAMNKDGVKENGIFSQLM
HNLKLPLKERVLYRLADDAKFLMVAGIDAPSQVLAITMFHVLRSPLVCRELREELQDKTAHSRDELCLNT
LEKLPYL TAVIKEGLRVSAVVTSRLPRIAPEETLEFRGWKIPPG
TPVSMSSHFILRDPAIFPDPLVFQPE
RWLKQSTTGSSLDRYLVPFSKGSQGCLGPNMAHAWLYLALATLLQRFEFSLFETTEENIRTVRDCFNGQT
KPGQNNIRVKVLTEFI
>CYP5096A1 Aspergillus flavus
99% to CYP5096A1 Aspergillus oryzae
AFL2G_09795 revised
MMPTFFQAVCSTCIALAIYTASLAIYRLFLSPLAKFPGPTLAALTGWYEVFFDVLLGGQFMWEIERLHGKYGPIVRINPH
ELHIKDPDYYNTLYAGPTRRRDKYLWFLSVGAPTSTFATPESDHHRLRRGMLSPFLSKQAVRDLEGVIKAKLDLLCEHMK
KAMRSGEAVELHAYFVSFAVDVVSTCAFGESGCFEELRRERLDDRWKNVVTGAFGKLLLTRHFPWLVVVFRFLPVWATAL
LTPVVRHIDYMEKGVENQMQHVYAMNKDGVKENGIFSQLMHNLKIPLKERALYRLADDAKFLMVAGIDAPSQVLAITMFH
VLRSPLVCRELREELQDKTAHSQDELCLNTLEKLPYL (0)
TAVIKEGLRVSAVVTSRLPRIAPEETLEFRGWKIPPG (0)
TPVSMSSHFILRDPAIFPDPLVFQPERWLKQSTTGSSLDRYLVPFSKGSQGCLGPN
(2)
MAHAWLYLALATLLQRFEFSLFETTEENIRTVRDCFNGQTKPGQNNIRVKVLTEFI*
>CYP5096B1 Aspergillus niger
e_gw1.2.1500.1|Aspni1
47% to CYP5096A1
MNIPQGLPTLKWSGIVSIGLTRGAFVCLFAIFVVAYVVGLVFYRLCLSPLAKFPGPRLAAATGLYETYYDVIRDGQFTWH
IERLHQKYGPVVRINPWEVHVKDADKYNTLYSGPTRKRNKDAWFSFVGWPQAIVSTEQHALHRTRRSVLRQFFSDQAILS
SEPLIRANIQALCRHFRSAQSRHYSLELHTAFLCFTSDTISQYAFGKRIGFHSLDQPELSTASKTKLNSTFELVQTTRHF
PWLCKLAHVFPWPAKLLNADFVGAYLQEKEVQDMVRKTITERDTGSSEEHRAIYPAILDDEKVPEDEKKFTRLTDDAIFL
LLAGTDAPGRALVMNLYYILQHPEVYERVRAELCASWTDASTEPRLTTLKQLPYFTAVLKEGLRLSALVTTRLPRAAPDE
ILQFHGWEIPRETPVSMTTYFILRDPEIFPEPSRFIPERWLLEPEDLRKLERYLVPFSKGTMGCLGPNMAWAWLYLVLGT
LLRKFEMKLHDTTERNVEMVRDKFLGQTERGMNRVQIKVLREYA*
>CYP5097A1 Aspergillus oryzae
GenEMBL BAE60821.1
MDLTLHLILFLCFWACYLLFEKQLQQRSPLPPGPTPLPIIGNILQFKRKQAVWETISQWSDQYGPIMSFK
VASRTIIVLSTNQAIRDVLEKTPVNSSRPRFIGVNENLTRSMMPIFLPISDKWKAIHRVQLSLVNSRSAK
GIAEIQLLTAKQHLFNMLENANYDIADHINRFTSNVVSTVLFGTNIGSVSQAKSNGKFGLADQFIASICV
EHALVDLFPILEHIPGVARLGASKGNAWFESIRQQYTEDIQRAINSPTWSMIKAAHQQKIGGMSEDAFRM
WNVEMEFALGMTSSMMIANLVAMAVSHSHEFRQVQSEIDRVVGPERLPTADDLAHLPRLHAFVKEGIRVA
PIVPFSVPHAAVEENEYMGYRIPVDAIILPNQWHINREPKYFEDPAEFKPQRWIDNPNLPGPAL
VGYGIR
ICPGRQTANNGLLIVLALMAWGFDLNHAGGVKEPPNVLETLIMKLPTSSIRYSCRSSVHRDLIQKEWLAS
DDDPSSILNTLGSSLGF
>CYP5097A1 Aspergillus flavus
99% to CYP5097A1 Aspergillus oryzae
AFL2G_03561
MDLTLHLILFLCFWACYLLFEKQLQQRSPLPPGPTPLPIIGNILQFKRKQAVWETISQWSDQYGPIMSFKVASRTIIVLS
TNQAIRDVLEKTPVNSSRPRFIGVNENLTRSMMPIFLPISDKWKAIHRVQLSLVNSRSAKGIAEIQLLTAKQHLFNMLEN
ANYDIADHINRFTSNVVSTVLFGTNIGSVSQTKSNGKFGLADQFIASICVEHALVDLFPILEHIPGVARLGASKGNAWFE
SIRQQYTEDIQRAINSPTWSMIKAAHQQKIGGMSEDAFRMWNVEMEFALGMTSSMMIANLVAMAVSHSHEFRQVQSEIDR
VVGPERLPTADDLAHLPRLHAFVKEGIRVAPIVPFSVPHAAVEENEYMGYRIPVDAIILPNQWHINREPKYFEDPAEFKP
QRWIDNPNLPGPALFGYGIR
ICPGRQTANNGLLIVLALMAWGFDLNHAGGVKEPPNVLETLIMKLPTSSIRYSCRSSVHRDLIQKEWLAS
DDDPSSILNTLGSSLGF
>CYP5098A1 Aspergillus oryzae
GenEMBL BAE60012.1
MGLILAFAVILLSTCWFLWYSRKAVFDRLPPGPRPLPFLKSRQELRQTRQWEALDDLHRQYGPLVGMTWG
GRPAVLIGKREIAKDLFGKRGSIYSSRARLVMGLDIMTGGDHVFFLPYGPKWKKLSRIQATFLNRPAVKH
YRPLQELESLHTLQDLLHSDDYEACFSRFQASLTHALAYGTRLHSATDPQLTELENIARTFISAATNSHW
MVDSFPILKYVPACLAPWKRFGQQIHAQTVSLFQGKMAVAEHTRSWNWVKHIRALKHTSGVTDHEMVYVI
GSIYQAGVGIITATLRLFIMACVLHPEAVKAAQDELDRVVGSDRLPTLNDLGHLPYVEAFVKEVLRWRPL
VLAATHSVTQDDDYRGYRIPRHAVILSNQWAMDMDREVWDSPEQFRPDRWMSDRKRMPSAFGLGQRMCAG
QYMAMESLLIMASRMLWAFTFEHAWEGGKRVEIDSWAFHEESLFLVPKPYRARIQPRDPHRLHVIQSTWQ
AAEKDIDPLLDQIGREIHTASA
>CYP5098B1 Aspergillus
niger
gw1.3.1436.1|Aspni1
51% to CYP5098A1
RRQAAKLPPSPLPSLPIIGSLHQLGKAWLRQSRDWHRNYGPLITLKLGGQTIVLVGSQEAASELLGKRGRLYSSRPHFVM
ALDLMSKGDHTVFLPYGPKWKLHNRLQMSILGVRASRQYHSLQELETQQTLLDFVEGDNYELIFQRFQASLIHTMAYGRR
LPKQNDQRLHEVEALSKAFINAATAGNYLVNIFPILKHTPTCLAPWKKYAQQIHDRTISLNRGHILEAEKTMAWNWVKHI
RSLKESESLTDHELTFVIGSIYQAGVDTMTNLLRLFLMASVLNPVAVRRAQAELDKVVGNRLPSFDDMERLPFINAYVKE
VIRWRPVAGLGAPHCVIQDDVYHGFTIPKGTTILANQFAMELDPELWEEPEEFMPERWLQRPDQELDIFGYGRRKCTGQY
QAMDSAYIVMSRMLWAFQFNHRYEHGRKVELGPWDLKQDGNLYVAKPFRADIKPR
>CYP5099A1 Aspergillus oryzae
GenEMBL BAE56799.1
MEHHTWALFVDKLDYKAVFGLLLTIIIAVVTTQILHVYTKCCPGIPSIPFHISVYDAYRRVSEIGFHNSR
LRPVLETHGAVNIWNSGQWAVLVTKPEYVVRILRNERVVAKGGFYGKVPHSTLAGLFGENIIDSHGELWK
QFTGVMKPGIQRPHSISSLKVASSKLIATFKREQQHAPSDRGVVIDDIIERWAIDVFGESFFDVDFGALN
GGTVRAQDALLAILWNLGGHLIHHFPMFERIGWPLRPTRPHCFSMIRELEEALIDITEKLKYPETPPDRF
EKVIYRLKRARDDGLMTDFHYRSNLKMMFFAGHENVKFAFIATLWELSQNPQMQEKLYREIAAHIASSSD
GDDLKSLPYLTAVLAETLRLYPPVSQLINRKTLEPVYLGNGITIPQGMWVGWTAYGVHTDPNTWGPTAHE
YQPERWGDDVHAIQRAISQQQVRGSYIPFNAWTRSCIGSEFALLQLRVTLYEIVRHFEITSAPDYRYSIKV
(0)
NASLEPYNCRLIFKDRL*
>CYP5099A1 Aspergillus flavus
99% TO CYP5099A1 Aspergillus oryzae
AFL2G_07491
MEHHTWALFVDKLDYKAVFGLLLTIIIAVVTTQILHVYTKCCPGIPSIPFHISVYDAYRRVSEIGFHNSR
LRPVLETHGAVNIWNSGQWAVLVTKPEYVVRILRNERVVAKGGFYGKVPHSTLAGLFGENIIDSHGELWK
QFTGVMKPGIQRPHSISSLKVASSKLIATFKREQQHAPSDRGVVINDIIERWAIDVFGESFFDVDFGALN
GGTVRAQDALLAILWNLGGHLIHHFPMFERIGWPLRPTRPHCFSMIRELEEALIDITEKLKYPETPPDRF
EKLIYRLKRARDDGLMTNFHYRSNLKMMFFAGHENVKFAFIATLWELSQNPQMQEKLYREIAAHIASSSD
GDDLKSLPYLTAVLAETLRLYPPVSQLINRKTLEPVYLGNGITIPQGMWVGWTAYGVHTDPNTWGPTAHE
YQPERWGDDVHAIQRAISQQQVRGSYIPFNAWTRSCIGSEFALLQLRVTLYEIVRHFEITSAPDYRYSIKV
(0)
NASLEPYNCRLIFKDRL*
>CYP5100A1 Aspergillus oryzae
GenEMBL BAE65915.1, AP007174.1
29% to
639A1 very poor match to other P450s
C-term
on BAE65915 gene model is not a P450 seq = MFS transporter
1252988
MPAISLSLIGIGVVAVGTVWALWALTRKLQVPNNYPNAPRSLPYSIPFLKSTIPFVLDGLNLFRQAS (2) 1253188
1253239
LYCQDRWPLRVDLLNGEVYIVQGAKNIASIFSTPGLTVTQAYGIALKHCFGMEQKAVDAYLADTSGSWHRPIP
GSQTPWHGRVSYHTHENLVRGLLGAGLDPTTERIERLLLASLEGAVSRTSEWTYGMDLTEFFETHLGSAI
LQALYGPLLVTKNSDFNRNLWRYDKQIMRLAKRLSSWLIPEAYRLRDELLGAIMRWHQQATLLSETIPSC
ERTSGGEADPYWGSAMMRERNKMLLSIEGQDAKSVASTDLGFIWA
(2)
SVTNVVPSTMTLCTHMYRDHSLVEN
IRLAALNCIRPGATLRFDLNKLGKQPLLLSMYAETLRFGVQIHIPRCSPHQPLSVAGVTIPPDKMIFINT
SLAHTDESVWNTRNGEHPLDTFWAQRFLIDPKDEGSGPTRKECSQPLESTPRGEYKRMDGQGSSSGQFTL
EGLDGSWIPYG (1) 1254606
1254672
GGQHACPGRILAKRIILLASSMMATMFDIELLAPNSLQFGSPRFGFGVRKPSAQVPFRI
RRRKSVSQDPFIC* 1254893
>CYP5100A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000177.1
98% to
CYP5100A1 Aspergillus oryzae
AFL2G_11920 this gene model has wrong C-term, revised
22528
MPAFSLSLIGIGVVAVGTVWALWALTRKLQVPNNYPNAPRSLPYSIPFLKSTIPFVLDGL 22707
22708
NLFRQAS (2) 22728
22785
LYCQDRWPLRVDLLNGEVYIVQGAKNIASIFSTPGLTVTQAYGIALKHCFGMEQKAVD 22958
22959
AYLADTSGSWHRPIPGSQTPWHGRVSYHTHENLVQGLLGAGLDPTTERIERLLLASLEGA 23138
23139
VSRTSEWTYGMDLTEFFETHLGSAILQALYGPLLVTKNSDFNRNLWRYDKQIMRLAKRLP 23318
23319
SWLIPEAYRLRDELLGAIMRWHQQATLLSETIPSCERTSGGEADPYWGSAMMRERNKMLL 23498
23499
SIEGQDAKSVASTDLGFIWA (2)
SVTNVVPSTMALCTHMYRDH 23678
23679
SLVENIRLAALNCIRPGATLRFDLNKLGKQPLLLSMYAETLRFGVQIHIPRCSPHQPLSV 23858
23859
AGVTIPPDKMIFINTSLAHTDKSVWNTRNGEYPLDTFWAQRFLIDPKDEGSGPTRKECSQ 24038
24039
PLESTPRGEYKRMDGQGSSSGQFTLEGLDGSWIPYG (1) 24146
24215
GGQHACPGRILAKRIILLASSMMATMFDIELLAPNSSLQFGSPRFGFGVRKPSAQVPFRI 24394
24395
RRRKPVNQDPFTC* 24436
>CYP5100A2 Aspergillus niger
fgenesh1_pg.C_scaffold_9000313|Aspni1
61% to CYP5100A1
MNTAIIPGAAAALALIFFILRALSARSRVLNKKPAAAPLTVPYTIPFLRSTFSFVFDGPNFFIRASRFCQGRWPLRVGLL
GDEVYLVQGHKNISSIFSNPKLTVTRAYGVVLKYCCGMDQKAVDVYVSDTSGSRERPIPGSRIPSNRRVGYHTHENLFHG
LLGRGLGHTTERFDAAIKSSLDNAVPTGPTWTYVDDLTEFFEDHLGAAILETLFGPLLLTESPGFHRTLWKYDRYIMSMA
KRLPSWMIPEGYRLRDKVLSGIMKWHKRATELSAKHSADVGEDDPYWGSAMMRERHKMLLGIDEQDLRSVASTDLALIWA
DSSLVAELRSSLQDSIQPESGSLHYNMDKISKKPLLLSLYAETLRYGVQIHIPRCSPQQPLEIGKGVIQPDKLILINTAL
AHTDEEVWNTRDGQYPLDTFWGRRFLVDPLDPQSGPLKPSSAAYEFMKEQMRDKNSSTTGEQFTVQGLEGIWIPYGGGQN
ACPGRLLAKRIMLLTTAMMVTMFDVELLEPIPHFDSRRFGFGVRKPVTKVPFRIRRRC*
>CYP5101A1 Aspergillus oryzae
GenEMBL
BAE65910.1, AP007174.1
first
exon may be wrong
MGRSRSTDWR ()
NSSALFARAKKEFRHKLCALRIAGQDMVMVTTAAQIAAIDKDSPTFAFEPFVDLVYDEIA
TVSRESKPLLWRTPAEGYKSLFPSAKQMTAAHTGIHLLHKQLTQPDAMHRFMTNSLVHVNNTLQWDSFYN
TSVLAATADVKVVSLECLCRDVIIDAQLTSFFGPRILEIEPDIRSFLKAWDSISWKVSYRLPSFLAKHAT
QLRDHLIEVLVKYYAFPAEERPGSVSFVNDVYDDYKQAGIPDRDIAGIVFTILWGLNSNVNAISYWMIAH
LMNNPTVVNEIREEIAPMMRALDSSPTIDGTILADVSKDPLLNSCPIMNSTFNETLRFTATGSSFRETTR
DTTMDGRRIPKGTKNIIPQRTQMMHSAAFGPDPETFDCYRFYRNKSLLRKVEFRGFGGGTTLCSGRVVGR
HQVLAYLALLFWRYDLEVIGPDQEVLGVRGKGFPRLDEAKPSLGPGKPIDGDDQILRLTRRNV
>CYP5101A1 Aspergillus flavus NRRL3357
GenEMBL
AAIH01000177.1
99% to
CYP5101A1 Aspergillus oryzae
AFL2G_11924
12856
MGRSRSTDWR ()
NSSALFARAKKEFRHKLCALRIAGQDMVMVTTAAQ 12677
12676
IAAIDKDSPTFAFEPFVDLVYDEIATVSRESKPLLWRTPAEGYKSLFPSAKQMTAAHTGI 12497
12496
HLLHKQLTQPDAMHEFMTNSLVHVNNTLQWDSFYNTSVLAATADVKVVSLECLCRDVIID 12317
12316
AQLTSFFGPRILEIEPNIRSFLKAWDSISWKVSYRLPSFLAKHATQLRDHLIEVLVKYYA 12137
12136
FPAEERPGSVSFVNDVYDDYKQAGIPDRDIAGIVFTILWG () 12017
11949
LNSNVNAISYWMIAHLMNNPTVVNEIREEIAPMMRALDSSPTIDGTILADVSKDPLLNSC 11770
11769
PIMNSTFNETLRFTATGSSFRETTRDTTLDGRRIPKGTKIIIPQRTQMMHSAAFGPDPET 11590
11589
FDCYRFYRNKSLLRKVEFRGFGGGTTLCSGRVVGRHQVLAYLALLFWRYDLEVIGPDQEV 11410
11409
LGVRGKGFPRLDEAKPSLGPGKPIDGDDQILRLTRRNV 11296
>CYP5101A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02005071.1
98% to
CYP5101A1 Aspergillus oryzae
runs
off the end
this
seq does not show up in the Broad comparative blast server
17 QQMTAAHTGIHLLHKQLTQPDAMHEFMTNSLVHVNNTLQWDSFYNTSVLAATADVKVVSL 196
197
ECLCRDVIIDAQLTSFFGPRILEIEPNIRSFLKAWDSISWKVSYRLPSFLAKHATQLRDH 376
377 LIEVLVKYYAFPAEERPGSVSFVNDVYDDYKQAGIPDRDIAGIVFTILWG 526
594 LNSNVNAISYWMIAHLMNNPTVVNEIREEIAPMMRALDSSPTIDGTILADVSKDPLLNSC 773
774
PIMNSTFNETLRFTATGSSFRETTRDTTLDGRRIPKGTKIIIPQRTQMMHSAAFGPDPET 953
954
FDCYRFYRNKSLLRKVEFRGFGGGTTLCSGRVVGRHQVLAYLALLFWRYDLEVIGPDQEV 1133
1134
LGVRGKGFPRLDEAKPSLGPGKPIDGDDQILRLTRRNV
1247
>CYP5101A2 Talaromyces stipitatus ATCC 10500
ABAS01000018.1
73% to CYP5101A1 Aspergillus flavus
N-term not identified
66857
NSNKLFARAKKDFNRKLCTLRIAGQDIVMVTTAAQIAVIDKERHIYAFEPFVDLIYDEVA 66678
66677
RVSPKKKFILWQTPAEGYVSVFPNPRQMTAAHTGIALLHKQFTQPDAVHQFMATSLACVN 66498
66497
NTLQWDSFYKTSVLASTPTIKVISLEFLCRDVIMDAQVTSFFGPRLLELEPNLRSLLKKW 66318
66317
DLESWRVSYKLPSALSRRATCLRDYLIDILTQYYTLPVEQRAGSVAFVNEVYDDYKHAGL 66138
66137
SDRDIAGIVFTILWG ()
66018
LNTNVTVVSYWMIAHLTNNPTVVNQIREEITPVMQKIDANPTIDGPALAELTKNPLLNEC 65839
65838
LIFNSTFNETIRFTATGSSFRKTTRDTTLEGRRIPKDTTVAIPQRVQMMDEEAFGPDSYT 65659
65658
FDCYRFFRNKSLVRKVEFRGFGGGTTLCSGRTVGRHQVLAFLAILLWRYDLEVVRPDQEA 65479
65478
LGVRGKAFPRLDEAKPSLGPGRTMDGDDQILKMTRRKM 65365
>CYP5102A1 Aspergillus oryzae
GenEMBL BAE65870.1 AP007174.1
heme
signature very altered only C is conserved
EST
EY425739.1 confirms N-term
EST
EY432141.1 confirms C-term
Revised 3/15/2009
1128173
MVVCVITVLILGFLASVRALCNYTRLSTVPGPLFTGLSDLWRTYARSTSDYGCSLAGLH
MKYGKVVRLGPRSISVSDPTAIFPVYNGRPSER
(0) 1128448
PIFEHGDRIVFTQGSFTKSADIESSLMSKVDRRRSLDSAMR
1128625
YEGIIDQAANNLITSLRQRPLVRLTTLLQGFATEFINRLVLEESATQVMPFSAQGASCHW 1128804
1128805
YNRTGKWLKLPMIEYVLLRSPAARLKRRRGISFVPRKVQGGINGSQSSRAMNDGGISYNI 1128984
1128985
SLPRSYSNADGAYACIAMAFVSTFSSLLKHENVMTRLRSEIDTAFSKGLLSDPPRWQELG 1129164
1129165
KLRYLDAVIKESMRQLPSLGYNREVVTPPEGAIVAGYYIPPGTMMELHSEALRDDPGIYG 1129344
1129345
EDVHTYRPARWLTADLRQRWAMNQNLQQLSTSINDCPKVRVTWLELKKIVVLILLKFN (0) 1129518
LQLVRPGEGPIPSERSDQGLPPSMAYCTPRNH*
>CYP5102A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000069.1
98% to
CYP5102A1 Aspergillus oryzae
AFL2G_11964 model wrong at N and C-term, revised
27804
MVVCVITVLILGFLAFVRALCNYTRLSTVPGPLFTGLSDLWRTYARSTSDYGCSLAGLHM 27625
27624
KYGKVVRLGPRSISVSDPTAIFPVYNGRPSER (0) 27529
PIFEHGDRIVFTQGSFTKSTDIESSLMSKVDRRRSLESAMR
YEGIIDQAANNLITSLRQR 27296
27295
PLVRLTTLLQGFATEFINRLVLEESATQVMPFSAQGASCHWYNRTGKWLKLPMIEYALLR 27116
27115
SPAARLKRRRGISFVPRKVQGGINGSQSSRAMNDGGISYNISFPRSYSNADGAYACIAMA 26936
26935
FVSTFSSLLKHENVMTRLRSEIDTAFSKGLLSDPPRWQELGKLRYLDAVIKESMRQLPSL 26756
26755
GYNREVVTPPEGAIVAGYYIPPGTMMELHSEALRDDPGIYGEDVHTYRPARWLTADPRQR 26576
26575
WAMNQNLQQLSTSINDCPKVRVTWLELKKIVVLILLKFN (0)
LQLVRPGEGPIPSERSDQGSPPSMAYCTPRNH*
>CYP5103A1P Aspergillus oryzae
GenEMBL BAE65635.1 AP007171.1
removed some seq
14
P450 genes and 2 pseudogenes on this contig
46% to
AAGI01000167.1 Phaeosphaeria nodorum
37% to 54A1,
38% to 54B1, 39% to 54C1
revised
3/19/2009
MEVQYILGILHNLDLAIWAVLIFIAFVLVTQAHYKAQLAKLPTFETDKGNEKWRRTYSDSARMLYQEGHKK
(0)
FKDQAWIMPTSDGRKNVVVPGRLLSE
LSKLPETVLSFPTAINKVLEVKYTKVAPDEPFAPYCIK
ADLNPALSRLNPIIYREVENALEDEIPQCEDWTPVFIYRKLLNTVAKVSGRIFVGAELSHNKDYLDTAIN
YTIELGNAVQAVKQMKPWLRPFLAWKLPEVQQLNK
REEMAIRFLEPIIQARREASKDPD &
YQKPDDMLQWFLNRSEDYKVHS &
RRIVKMQLLVIFAGIHNTTVTATNVLYNLAVSPEYMQPLREEICKAISDNDGTLTSRALQQVEKLDSF
MKETIRFYP QNSLPSRAKR GQYIPPGTSIEAPLQAIYQDDSNYPDSDTFAGFRFYKIRQGGGATVHARNQ
FVTSNEQNLVFGYGKHACPGRFLAAAEIKMIVSKILLTYGFKNADNWTERYSNYEVGRL
NMPERAIPLLFRKTTAQDSSL
>CYP5103A1P Aspergillus flavus
93% to CYP5103A1 Aspergillus oryzae
MKSTYFPSQPQAWFHHYRTMEVQYILEILHNLEAAIWAVLIFIAFVLISQAHYKAQLAKLPTFDIDEGNEKWRRTYLKSA
RRLYQEGYKK (0)
FKNQAWIMPTSDGRKTVVVPGQLLSELSKLPETVLSFPTAINKVLEVKYTKVAPDEPLAPYCIKADLNPA
LSRLNPIIYREVENALEEKIPQCEDWAPVFIYQKLVNTVAKVSGRIFVGAELSHNKDYLDTAINYTIELGNAVQAVKKMK
PWLRPFLAWKLPEVQQLNK
REEMAIRFLEPIIQARREASKDPD
YQ*PDDMLQWFLNRSEDYKVHST
RRIVKMQLLVIFAGIHNTTVTATNVLYNLAVSPEYMQPLREEICKAISDNDGTL
TSRALQQMEKLDSFMKETIRFYP &
QNSPPSRAKR
GQYIPPGTSIETPLQAIYQDDSNYPDSDTFDGFRFYKIR
QGGGATVHARNQFVTSNEQNLVFGYGKHACPGRFLAAAEIKMIVSKILLTYDFKNADDWTERYSNYEVGRL
(0)
NMPETAIPLLFRKTTAQDSSL*
>CYP5103B1 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000167.1
46% to
CYP5103A1, 41% to 54A1 some gaps in seq
4489
MDVEKLAGLAYTFQTITIASLVFVVLTYAPKLMRRLQLAKLPSMPGKDYATS 4334
4333
ARKLYKEGHQKV (?) 4298
4170
SIGEHSVVVPPHFLPELRKLPDDVLSFAAAIDN (0) 4072
4025
VMETKFTGVDSEDSNTVHTIKSDLTPALPRLNQAVCTEVDAAMREALPSCEDWTEVDIN 3849
3848
DKLLDIISKVSGRVFVGPDLCHDPEYLELGRNYTVYLMEALFAIKRTRPWLKSFVGHRLP 3669
3668
EVKRLRDVEKKAIKFVQPIVRERLEAEKSDPNWQKPDDMMQWLINRYNKDGHVSVEHIAK 3489
3488
CQLGLILAASHTTTMTTTNILYTLVSTPEYVEPLREEIRNAMHGNGGSITTRALQEMVKL 3309
3308
DSYMKEVLRLYPAG (?)
3165
GQYLPPGATVQVPTAAIYTDSENYPDPDTFDGFRHSKLREGGTATDHSRNQFVTTNETNL 2986
2985
GFGYGRHACPGRFFAANEIKMIVARLILNYDMKMPGDATERYPNVDIGRSCIPCPGKTLM 2806
2805
FKRV* 2791
>CYP5104A1P Aspergillus oryzae revised
GenEMBL BAE64914.1 AP007171.1
pseudogene just upstream of CYP5117A1 about 800bp, missing C-term
14 P450 genes and 2 pseudogenes on this contig
MQQNMIIPSFWTGTAIIGLVACAYVSYQCLLSPLARFPGPFAAKLSKGWRAYKTANGQWHRKLVDLHRKY
GHVVRIAPNELSVGDPSSFRKIYSPAEAGNGFNKAACYSVVQGNRPFDLTGERNEKVHSEQRKLVATAYS
MSSMVHFESKVNVVIETVIHKLEARCRKTIDLGHWLQMWAFEPTRPLLNSLKPDVIGSVSFSQPFGYVES
GDDEGVFKRIQNAMGSAAWLMHAGWLFRLHQKLIPICGNWLAVNDRNGYFFQVACREVSGRINRGGDDKD
IIGQLLETQKIKPQLKDLDISFMMTSNVFAGSDSTSIAFQSIFYLLLTHPAAHDRLMRELREREEKGELS
DPVSFQEAESWPYLQAIIYEAMRLYAPAAFVLDRVVPPEGMMIEDKFVPGNTVVGSSAWVIHRNPEIWGP
DVDTFR
PERWLDDRKDEY
(1)
KRYFFAFGGGSRTCIGK
(1)
NISWLEIGK
(0)
LVPTLLRHFEMRLENGAVLKEEFC
(2)
ALVFLKGLKVHISRRRV*
>CYP5104A2P Aspergillus terreus NIH2624 revised
GenEMBL AAJN01000022.1
probable pseudogene 54% to CYP5104A1P
ATEG_00956.1
MKLLALLLDSSAIATLLLA
68053
VTTGYVVYQVFFSPLAAFPGPFWAKVTYWYWAWRSMRGQAHRDLVNLHQRYGSVVRLGPDYL (2) 68238
68297
ERGKSKSFQEIYS (?)
PEEAGGKFRKSAVHDTVTGTRPFDLLAQRDE
68476
68477
KIHSGQRRLVASAYTMDSIVYLEPMVDSLIVSTMEKLSTLPGDIDLGGWIQLFAF () 68641
68712
DVIGAISFSRPSGFIEAGDDGGIFRRMQNSLSSISWLMYVDWFYSLYQRLMPVIGNWLAA 68891
68892
NDRNGHFFNFARQEITARKDRAGNTKDMASQLFAVQHTKTELDDTNIAFMMASNVLAGSD 69071
69072
TTSTSARAVIYLLLKNPKSLQRLLDETEERKSDGRLSYPVKFQEAESWPYLQAVMYEAMR 69251
69252
LYPAVGRNLDRDVPAGGLRIGDHWVPEG (0)
TMVGSTAWAIHRIPEIWGPDVEDFRPERWL
69479
DEE*VGDL
(1)
KRYFFAFGGGSRTCIGR
(1) 69613
NISWLEISK
(0)
FVPTLFMRFDVDLVPGTALEEFCG (2)
ALVFLSGPDVQLKLRPDFFNTAVKASTAT*
>CYP5104A3 Aspergillus niger
e_gw1.9.635.1|Aspni1
58% to CYP5104A2P
MQLLSLLVNPFTAGILLLLSTGGYVIYQCFLCPLARFPGPFLAKLTNWHRAYLTYEGRSHHRYLAFHRKYGAVVRTGPNV
LSVADPTAFREIYKAGGKFAKSASYSVPKESQAFDLFRQRNEKIHGEQRKLVARAYSMDSMVHLEPNVSSILTSMVQKLD
TLSGVVDLGAFLQLFAFDVIGAVSFSRPFGYVIAGDDNGVFSRLKQSLRSMSWLMSVPWFYDIHQKLKPFIGNWLAVNDR
NGYFYQFATQEIVSRKDRGGDDRDIINQLFAIQKTKPHFSDTDMAFMMTANVFAGSDTTATSLNAIFYLLLKNPTVYQRL
MQELEEKKSKGELSDLVTFQQAESCPYLQAVMYEALRLYPAAGLQLNRDVPEGGMKIGNYYVPEGVMVGSSAWVIHRLPE
IWGPDFEEFRPERWLEGDATAHTVSERFYFSFGDGSRTCVGRSKYFFFFFFFLTNCLLVVTMLTSCQT*
>CYP5104A4 Hypocrea lixii
AJ896070 EST for C-term of CYP5104A
57% to CYP5104A1P Aspergillus oryzae
AAALELVDPPGCRNSAPARVLSKLRAELEERRAAGSLSRIVTFQEAEASPYLQAVMHEAS
RVFSPTGFNASRDVPKEGMMINGVFVPGGTVVGSNAWVIHRLPEVWGVDFEEFRPERWLE
RESSGELKRFFFAFGGGTRTCIGRNISWLEIGKLVATLVMRYDFQLVDEANITESYSGLV
FMKGLKVQLKSREA*
>CYP5104B1 Aspergillus niger
e_gw1.3.2127.1|Aspni1
47% to CYP5104A2P missing C-term
MGIISDLTRPDSTHHEPITYLLAYIACLSLLSVIPYVLYIRYYSSLAKVPGPFWASLSRWWLVLFSDKGNMHRLYPRLHE
EYGKLVRVGPNEVSVADLNAIQLIYGAGNKFAKSDWYSVWQGRRKFDLFAERNETIHGAQRRLVNNIYSMSSLKDFEHGV
DAVVERLMQCMQRQGSDATVDLGKWVQLFAFDVIGEITFSKSFGFLENGTDGGAFRQIENALRSASWVGQVPWVYWLHDY
MTPIIGSRLGIAARHGTIRQIAAREIMARREGKHVEEAKEEQDILSKLFDVQKKKENQLSDDDVLSMATSNVFAGSDTTA
ISIRSIFYHLLKNPTCLKKLRDEIEDRKRQGRFSDPVTLDQANDMPYLQACMWEGLRLHPAVGMSLPRVVPKGGIMIDGC
FLPEGTTVGVNAWVVHRDASIFGDDVEAFRPERWLGEKTGDM (1)
RRYFFAFGGGSRLCIGK
(1)
NISWMEMSK
(0)
MIPTLLNRFDIQLANPDEPWQETCW
(2)
WFVKQEGLLVKLSPRKS*
>CYP5104B2 Coccidioides immitis
53% to CYP5104B1
CIMG_00153.2
MAEGFIYAVSNSRREDVLSNALVIGIALILAITFWVHSRDPLRSIPGPLWAKWTPFWLVHYARSGNMHRQMIATHKKYGR
LVRVGPNEVSTANPEALKAIYGGDFRKSDWYSVWQGLRKWDLFGERNESIHRAQRRLVSQIYSLSNMKKLEPYVDKAVVL
FMTKMSEMQGQQVNMSKWAQLFAFDVIGEVTFSKRFGFMDAGKDDGAFSLIDKSLRCAAWVGYVPWVYWTNLRLSPIIGS
HLAVTARQGSLLTFAAKAIAERKKRGSDHQDILGQLFDVQREKPELDDICVTSMVASNIFAGSDSTALSISSLLYHVVKN
EQCKKRLVEEIDATARANNIGHGDIFSLETANNMPYLQACMWEALRCHPAVGMNLGRVVPPQGVKIDGQYLPGGTVVGAN
AWVIHQDKDTFGEDAHKFRPERWIEEPDRVSQMRRVFFTFGGGSRFCIGKNIGWLEMSKFVPTLFHDFEIALADADQKLK
ELAW
>CYP5105A1 Aspergillus oryzae
GenEMBL BAE64645.1, AP007171.1
36% to
682B1 missing PKG motif, frameshift at YIL/PGT,
this
restores the PKG motif, possible pseudogene
262325
MTLFQVVETSFILLALWTSVEAIRRLFSHSLSHIPGPRLAALTWWYEFYYDAVQSGQYVFKIQELHKQY (1)
262531
262599 GPIIRITPDEVHINDVGYLDTIYAPSMTRLDKYDYQLRTLRVPGGVGTTADYYLHRIRREALPPFFSKRNV
LWLESVITEKVNQLCGLIAKHAATETPVNLSDAFYGFSNY (2)
262931
VVNNFLFAHQTDVLADEQEAARLRHNSHEL
LKGINMNKHFPWIPDILEALPQLLTRPTMPPGLIDMLELFD (0)
RVRAELITIITRISSNTSGEKESINTGAK
GSVYESVLDSPNLPASEKALLRLEQEGALLTLAGTESPAQTLNIIFYHLLANPSLLTKLREELATLPTLS
TWTQLEQLPYLSAIIEEGNRLSFGVTARTARIQHTPITYTPSAYVTTPDPTHKSYIL
263721
263721 PGTPVSITTLSAHTAESVFPDPYAFLPERWLGD
EGRERRKFQLTFSRGGRKCLGIELARAELYLVTAALVRKFDLVLWETDERDVSFEHDYHVAMPRDGSRGV
RVVARIRGGLALSRDRLTTK 264089
>CYP5105A1P Aspergillus flavus NRRL3357
GenEMBL AAIH01000184.1
pseudogene with 4 stops, 96% to 5105A1
AFL2G_04889
38647
MTLFQVVETSFILLAL*TSVEAIRRLFSHSLSHIPGHRLAAFTWWYEFYYDAVQSGQYVF 38826
38827
KIQELHKQY (1) 38853
38921 GPIIRVTPDEVHINDVGYLDTIYAPSMTRLDKYDYQLRTLRVPGGVGTTADYYLHRIRRE 39100
39101
ALPPFFSKRNVLWLESVITEKVNQLCGLIAKHAATKTPVNL*DAFYGFSND (2) 39250
39309
VVNNF*FAHQTDVLADEQEAARLRHNSHELLKGINMNKHFPWIPDILEALPQLLTRPTMP 39488
39489
PGLIDMLELFD (0)
RVRAELTTIITRISSNTSGEKESINTGAKGS 39668
39669
VYESVLDSPNLPASEKALLRLEQEGALLTLAGTESPAQTLNIIFYHLLANPALLAKLREE 39848
39849
LATLPTLSTWTQLEQLPYLSAIIEEGNRLSFGVTARTARIQHTPITYTPSAYVTTPDPTH 40028
40029
KSYILPPGTPVSITTLSAHTAELVFLDPYAFLPERWLGDEGRERRKFQLAFSRGGRKCL 40205
40206
GVELARAELYLVTAALVRKFDLVLWETDERDVSFEHDYHVAMPRDGSTGVRVVARIR*GL 40385
40386
ALSRDRLTTK 40415
>CYP5105A2P Botryotinia fuckeliana B05.10
GenEMBL AAID01002562.1
pseudogene 61% to CYP5105A1, 36% to 682B1
frameshift at KIQ, also after PIMP, one stop, runs off the end
1431
MAFAQLLGTGIILSLILTIAEATRRLYFHPLAHIPGPKLAALTWWYESYFDVIQPGQYVF 1252
1251
KIQ
NLHKQY (1)
GPILRNTPDELHIQDVGFLDTVYAPSASPRNKY
1072
1071
EYQLRTLRIPGGVRTTARYDLHKKRRAALSPFFSKRNVLHLEPLINKKVEQLYQMIDKHA 892
891 KEQSPAN*SDLLFAFSND (2)
VVTNFLFNHQVDVLSDETRAVELRH 712
711 NSHQLLMGININKHLPSIPDFSESLSLSISKPIMP
PGLIDMHAPFD (0)
519
RVRTELTDIMSSKPSEVSSEKLLGPTKKESVFASILDSAILPPTEKTLLRLQQEG 355
354 SLSVLAGTESPAQTLKIIFYHLLTNPAIIAKLRAELDTAPTPTSWATLEHLPYLSAVIDE 175
174
GNHLSFGVTARTARIADEQLTYTPSSHVTSTTNKGTFYKIPTGTPISITTLSAHTAET 1
>CYP5105A3 Aspergillus niger
fgenesh1_pg.C_scaffold_8000274|Aspni1
66% to CYP5105A1
MSLLWNVGVAALLAVLWTASEAVRRLYFHPLAHIPGPRLAALTWWYEFYFDVIRPGQYVFKIQELHTRYGPIIRITPDEV
HVNDVGFLDTIYAPSMIRRDKYGYQLRSLRVPGGLGTTTDHDLHKVRRESLTPFFSKKNIQYMEGLITDKVDQLKQLIST
HVARDTPVNLSDVFFAFSNDVVNNFLFAHRTDVLASEPKAATLRQNSKELLMGININKHFPQIPDFLESLPMSISRPVMP
PGLIDLLALFDVRLCAEQMNQRVREEIFMIKKDKESSVAHKKNIGPTGKASVFDSLVDNPNLPASEKTLLRLQQEGALLV
LAGTESPAQTLNIIFYHLLANPALLEKLRRELRAVPVPSSWTQLEQLPYLSAVIEEGNRLSFGVTARSARIAYEPLTYTP
SAYVSSTCPPSTRSKSYIIPASTPVCTTTLSAHTADTVFPDPFVFDPERWLGDAGKERRRFQMAFNKGGRRCLGIELARA
ELYHVVAALVREFDMALFETDADDVAFMYDYQVAMPKMGSKGVRIMAKLAH*
>CYP5105B1 Mgr050 Mycosphaerella graminicola
43% to CYP5105A1 Aspergillus oryzae, 40% to 5105A3, only 34% to
682A1 (next closest family)
MISLQLTLLGLGTLAAWLLWTVLQRLVLHDLASVPGPTLPALTRWYECWYEIWQPGKYPFKLKELHEKYGPILRPVPDEVHINDPDFLDTIYAIRNRNNPTIRGLLVDQSVGGAEDWHVHKMRRDALNPYFSQKFTLSMQDLMLQKRDQVIEQFFTASRSGQPFNLSDVYFAFSNDLVRNFCFGSDSDLLHNLPEAQIQRKNLTRMLTGVKVNKHFPFVPRLLANILPVFLGNGAIPPAVMDLMRFRARCRADIEAVFKDRKNDNKGRHSIFYELRDSPSLPPEEKTVRRLQDEAQLLVMAGTESLAKSLAIASFHLISNPSTLSTLRAELSSARQTSQHPDQPVPLTTLLTLPYLNAVITEANRLSFGVTNRIVRYSPTETLSYTASSGPHKGTNYVFPPRTKMSCCTYCTHTNPSLFPDPLKFLPERFLGEGDEVAKRKRCMMALGKGHRRCLGINVANAGMCLIVAAVAEWDMKAWDTDERDVAFLHDYQVAHGRLDSKGVRVVV
>CYP5106A1 Aspergillus oryzae
GenEMBL BAE64452.1, BAE64451.1, AP007170.1
137250
MSFASALILVVAIWCIYVGWPWYRNWKQAKALHVPIVISPISTS
GAALQSLRYILDRDILPTWITRLAFVRLIQRNSRFQEKFAVHAEYGKLFILVTPATCE
LYVADVDAAKQVLSRWRDFPKPSSLLGMIFPERNA (1) 137663
GADWQRHRKLTARAFNEKLHEAVWAESTRNATKV
137909
MTKWNNTKPVYSTRSDMMALSLAVLFKACLNIDGDDKDDTRILAGDVAACQWHLDVVLKGISNPMALGRG
FEGIKKLKRSHKALGELLTEFVEARTIRPKLSAHADLLSSILAPTDHRGLSSDEVTGNLFLF
MFAGHETT
ANALIYIIHLMAIFPAWQDWALEEIDQLSHNRADGEEVPSYSQILPQTQRLRAIL
(0)
YETLRLYGPVPTLVRQTDPQAQTLVLPEQEVIIPKDTPVNVNTIALHTDPKQWGPDPLAWR
PDRWILQPCDSSLQKVSNELLKYLFAWGDGPRLCPGQRFSQIEVFAVLICFFKS
HRVELVPSRDQTMDQARSHALSLIQNSKVGLTLQMPDAESVGLRWVGR*
>CYP5106A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000668.1
only
one amino acid difference
AFL2G_08751
MSFASALILVVAIWCIYVGWPWYRNWKQAKALHVPIVISPISTS
GAALQSLRYILDRDILPTWITRLAFVRLIQRNSRFQEKFAVHAEYGKLFILVTPATCE
LYVADVDAAKQVLSRWRDFPKPSSLLGMIFPERNA (1)
GADWQRHRKLTARAFNEKLHEAVWAESTRNATKV
ITKWNNTKPVYSTRSDMMALSLAVLFKACLNIDGDDKDDTRILAGDVAACQWHLDVVLKGISNPMALGRG
FEGIKKLKRSHKALGELLTEFVEARTIRPKLSAHADLLSSILAPTDHRGLSSDEVTGNLFLFMFAGHETT
ANALIYIIHLMAIFPAWQDWALEEIDQLSHNRADGEEVPSYSQILPQTQRLRAIL
(0)
YETLRLYGPVPTLVRQTDPQAQTLVLPEQEVIIPKDTPVNVNTIALHTDPKQWGPDPLAWR
PDRWILQPCDSSLQKVSNELLKYLFAWGDGPRLCPGQRFSQIEVFAVLICFFKS
HRVELVPSRDQTMDQARSHALSLIQNSKVGLTLQMPDAESVGLRWVGR
>CYP5107A1 Aspergillus oryzae
GenEMBL BAE63455.1 AP007167.1
42% to 5107B1
601589
MIGEQYTSIITGFKSALAVSCIAVSLFLLSPWIAYARLPSSIKSPIKAKGPLSALRACLNEISAGAKTST
RGYELY (0)
SKKGQSFAMLNINFRPQVILPPEHVRWLVTQPEDILSHAKASDDADALGYIWPLFDASALHSFS
KVLQIDLTRNVTQTEKDVLEEVQHIMDELVGQTESWKEVNMVQAFERIMYQATQRVYVGLPLCRDSTYMG
YVKGYARSLGTAMVFAAQLTPWPLRQVTALLAGLPVYYYVLRVRSYLSPLFKERMERLKEKGGTQDDNLE
GEPRNLITWMSNGVLSGVGPKSISPSEMVTWLGIL (?)
602662 ALLPTDNLWTTCTNVLLDLLSSESEHAYLHTIREE
ARTVFASSKESGKPVSHGLHHIDSAIRESLRMNSLSPRSLHRQVVRRGGVVLPDGQKVPTGTWLCVLSGN
IQRDEDYYEDAQTYKPFRFVPKLTEAGGDKAPLLPLTNEKYLTFGYGRHAC
(2) PGRWFSFQVMKIVIAYILA
NYDIQPLEKRPDNIVFADLNIPHLSHIIRIKRMT 603339
>CYP5107A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000006.1
only
one amino acid difference
complement (71337-73087)
AFL2G_11056
MIGEQYTSIITGFKSALAVSCIAVSLFLLSPWIAYARLPSSIKSPIKAKGPLSALRACLNEISAGAKTSTRGYELYSKKG
QSFAMLNINFRPQVILPPEHVRWLVTQPEDILSHAKASDDADALGYIWPLFDASALHSFSKVLQIDLTRNVTQTEKDVLE
EVQHIMDELVGQTESWKEVNMVQAFERIMYQATQRVYVGLPLCRDSTYMGYVKGYARSLGTAMVFAAQLTPWPLRQVTAL
LAGLPVYYYVLRVRSYLSPLFKERMERLKEKGGTQDDNLEGEPRNLITWMSDGVLSGVGPKSISPSEMVTWLGILALLPT
DNLWTTCTNVLLDLLSSESEHAYLHTIREEARTVFASSKESGKPVSHGLHHIDSAIRESLRMNSLSPRSLHRQVVRRGGV
VLPDGQKVPTGTWLCVLSGNIQRDEDYYEDAQTYKPFRFVPKLTEAGGDKAPLLPLTNEKYLTFGYGRHACPGRWFSFQV
MKIVIAYILANYDIQPLEKRPDNIVFADLNIPHLSHIIRIKRMT*
>CYP5107B1P Aspergillus oryzae
GenEMBL BAE63454.1
heme signature incomplete
only 679bp from CYP5107A1 pointing away from each other
42% to 5107A1
one stop codon, possible pseudogene or seq error.
600910
MQIADMAASTTAQILVVSLGLLIFVLLCPWFGYLRLPSSMRWWPSIPSGPLSALRLSLKEYSGSRSSENG
YKAFSKKAEPFAICNPSFYPQVLLPPEQIPWLLSQPENVLSHEKANEDVHALPFLAPAFDNYDHLELIRA
IRTDLTRNIPNTEDAFLDELRHTTNEVLGAPGDNAWKEVNLTVALDSIIFGICLRLFFGVSLSRNRTFVY
YVKIFTRVTGAMMLFVSQLVPWPLKPVVGIVAGFPIYYYWVRLIIYLYPTFKERIQCLRTKKETPPADMV
TWMVDLAISQNPTRKVHISSLIVRLTLI ()
VFLPVDVLIAMTDNFFLDLLSSDPDRKYYNA
LRQEAEAAFTNRDKTQPISQSMPYMESTIRESLRLSPLSDRMLSRRVVHKGGITLPDGQFLPRGTWLAVA
AVGVHRDERTYEDPDEYRPFRFLSEDTETKEAKAMLVPVTSEKFLAFGHGRHSC
(2) 599384
599313 PGR*FAAHAMKLIIGYILVNYDIEP
LEKRPVNSVVGQTIIPQLDVKIRVRRRE 599155
>CYP5107B1 Aspergillus flavus
99% to CYP5107B1 Aspergillus oryzae
AFL2G_11057
MQIADMAASTTAQILVVSLGLLIFVLLCPWFGYLRLPSSMRWWPSIPSGPLSALRLSLKEYSGSRSSEDGYKAFSKKAEL
FAICNPSFYPQVLLPPEQIPWLLSQPENVLSHEKANEDVHALPFLAPAFDNYDHLELIRAIRTDLTRNIPNTEDAFLDEL
RHTTNEVLGAPGDNAWKEVNLTVALDSIIFGICLRLFFGVSLSRNRTFVYYVKIFTRVTGAMMLFVSQLVPWPLKPVVGI
VAGFPIYYYWVRLIIYLYPTFKERIQCLRTKKETPPADMVTWMVDLAISQNPTRKVHISSLIVRLTLI
VFLPVDVLIAMT
DNFFLDLLSSDPDRKYYNALRQEAEAAFTNRDKTQPISQSMPYMESTIRESLRLSPLSDRMLSRRVVHKGGITLPDGQFL
PRGTWLAVAAVGVHRDERTYEDPDEYRPFRFLSEDTETKEAKAMLVPVTSEKFLAFGHGRHSC
(2)
PGRWFAAHAMKLIIGYILVNYDIEPLEKRPVNSVVGQTIIPQLDVKIRVRRRE*
>CYP5108A1 Aspergillus oryzae
GenEMBL BAE63248.1, AP007166.1
all
the best hits are CYP51
but at
low 20% range, revised at N-term
1834519
MLEALLFRPSLLSFISAWLGTLGLALLLFSSRRASTKLPPRANGGIYFI
SDILVFLASPVQFVKQATGKHGSVFRIDCLVKQIFYLRGQKWNRFFLEMK
EDTWSFSGGI (0)
1834137
GMFLNKAANPGYFTHGRNLLGSINRGVNRSAALQSYGRLAGEEAHKSLQHWSQMPDVEIFESISRFVHRVI
VRCMMGEDFYDHHVDELYDLLQQMESLVGHPFNLLLPSWVPHLPGRQLAQARNRFAEIFRERLAARQLES
DVWRDSLDYINYTLNDPRTAQLADYYPSHHVVLMFAAHTSTVASIAWTIVE
(0)
1833514
LLRHPIYQEEIRESLATMSDIHQCAPLLACLREEG
RRYSGVHMFRTTKQPVSLEGSDYTVPEKSVVLISPYLTHHDPAIYPEPHEYQP
HRWLLPDGRLNPWNGSKEAAFLQFGAGNHRCPGENFAAIIAREFLAALLMKYEIEWGRDGAPADLSRLDF
TKVGSPWLEGDAAVRIRPRVFGS 1832966
>CYP5108A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000996.1
99% (4
aa diffs) to CYP5108A1 Aspergillus oryzae
AFL2G_08676
6424 MLEALLFRPSLLSFIAAWLGTLGLALLLFSSRRASTKLPPRANGGIYFISDILVFLASPV 6603
6604
QFVKQATGKHGSVFRIDCLVKQIFYLRGQKWNRFFLEMKEDTWSFSGGI 6750
6806
GMFLNKAANPGYFTHGRNLLGSINRGVNRSAALQSYGRLAGEEAHKSLQHWSQMPDVEIF 6985
6986
ESISRFVHRVIVRCMMGEDFYDHHVDELYDLLQQMESLVGHPFNLLLPSWVPHLPGRQLA 7165
7166
QARNRFAEIFRERLAARQLESDVWRDSLDYINYTLNDPRTAQLADYYPSHHVVLMFAAHT 7345
7346
STVASIAWTIVE (0)
LLRHPIYQEEIRESLATTSDIHQCAPLLACLREEG
7540
RRYSGVHMFRTTKRPVSLEGSDYTVPEKSVVLISPYLTHHDPAIYPEPHEYQPHRWLLPD 7719
7720
GRLNPWNGSKEAAFLQFGAGNHRCPGENFAAIIAREFLAALLMKYAIEWGRDGAPADLSR 7899
7900
LDFTKVGSPWLEGDAAVRIRPRVFGS
7977
>CYP5108A2 Aspergillus niger
fgenesh1_pg.C_scaffold_10000032|Aspni1
57% to CYP5108A1
MASMIEAIQARLADDEHLLAQPMIVAGALFFLLVVFQLRRAGGSKAFPSPRLGYPLVGDALAFLNRPVAFVQDATRKCGP
IFHVKILFANIVYLRGTQLNRMYVDVKEDIWSFGGGIGIFLKKIAIPGYFDHFRNLVGSLNRGINRKVTLDRYTELAGEE
ADKALLKWSQQSDVKVFEEASKYVHRVIVRTLMGQDFYDEHIDELYDLLHRMEDEIGHPLNLLLPDWFPHPPARRLGKAR
DRFAEIFAQQMAIRRQNPEKWKGSLDYITYTLEDPRTAHLQEYYPSHHTVLMFAAHTSTVASIAWTAMELIRNPEYVEAI
RQSFQTNEDVHQSPVLLACVKESGRHYSGVHMWRTTHRPVQLEDGYTVPENWVVCTSPYLTHHDPEIYEQPQQWLPERWL
RPTARLQNLNNATDAAFLQFGAGSHRCPGENMAGIIARELVSRLVKNYDFQWGSQGPAKIDVSNMDFSKVGSPWLQGDAL
IRIQPRKSAAM*
>CYP5108A3 Aspergillus niger
fgenesh1_pg.C_scaffold_4000032|Aspni1
54% to CYP5108A1
MWRIPVIVA
LVAGLLYWVRKQGSQPSRKIPQPRIGLPVVGDAHAFGKSPISYIRQATARCGPV
FQINLLLTKIVMLRGAQLNRFYVDTREEVWSFGDGM (0)
GLFLEKVVVPGYLSHLKE
MVSSLNRGVNRSIALEHYTRIAGEEARKIATNWAEKPDIEVFEQMSRYTHRVIVRCLMGQDFYDHHLDELLDLLHRMEAD
IGHPFHFLLPNWVPHGPARRLHHARDRMAAIFNERLQAREQNPEKWQDSLDYIAYTLKDSRTAHLRQYFAAHHTLLMFAA
HTSTVASIAWTVLELLRNPTHLEALKTALATDADIHRSPTLIATLKETSRRYSGVNMIRWARQPHQLPADAAPGKGNIVV
PENCIVSISPYLTHHDPETYADPHIWDPTRWLEGGRLSETQKSNRSEVTYFPFG
AGCHRCPGEQMAGMIAREMVAHM
VKTYDVRWSSTGPPEDFEQLDFSRVGSAWLKGDARVTVKRDKQGEMEEA*
>CYP5108B1 Aspergillus terreus NIH2624
GenEMBL AAJN01000021.1
43% to
CYP5108A1
ATEG_00916.1
revised
MLTQELQAIYANNAGFLITSL
70767
LAFALLALAVRSFLRSEKIPLVSAGLPILGNLQKYSLDPVGFIASATRLHGECFAVPML 70943
70944
FGRTIWLRSPQLNKEYLETRE (0)
DVWSFGDGMGLFLNKIVIPGYF 71123
71124
SHLRSMVGSLSRGISRKATLEYYAQVADEETAKAVDGWTCKSEAEKSVALFEEISFLVHK 71303
71304
IIVRCLMGQDFYDHHVRELYDLLRTMEANVGSIWHTVLPGWVAHGPARRLWRCRQRVQEI 71483
71484
FDFRLRERERSPEEWKKRLDYISYTLQDPATAHLSRFYGAHHTLLMFAAHTSTVASISWI 71663
71664
LLE (0) 71672
LLRSPHRLQRLREELATHALEQSPFLDALVKETG
71834
RHYSGNSDVRWARKPKTLRTEVASVPESRITIPEGTIVSISPYLTHHDPATWDNADTYLP 72013
72014
ERWLADPDLAKKMNEGGQLRYIPFGAGSHRCPGEKMAILIAKIAVARIVQSCDLAWGEGS 72193
72194
SENTLGGLDFSKVGSPWLKGDVQVRFQ
72274
>CYP5109A1 Aspergillus oryzae
GenEMBL BAE63087.1, AP007166.1
36% to
573A2
revised 3/15/2009
1411903
MSPFIFAVTLTFAILALGILRRRYFHPLSRFPGPFLGSVTSLYQTYWHVHPNKTLHDTELHKKYGPIVRY
SPNGLIVNDPALLPVIYNRRANKTDFYAPVFDTHSTFTRKDYREHVASRKAISHAYSVTNTRLFEPQVDG
ILSELISLLSESATEKRLVDIMEYGS (2)
WFTYDVTSLFVCGKPFGFVEKRTDVKGLIQNKNKVLFIIFIMTIQEN
LSWIVRNTRLGRRYLMPHPTDQSGLGVVMAERDRIVDAVIDNDGKVKRHLLVKGSLLSSLMEILGTEGCP
LSLVDVKAEIFFAMLAGSSVTPSQLARVIFHISRNFKVQEKLYEELVAAEQDGRIPPLSAIISDEQAHRL
PFLSACIREAQRYAPTMSQLPRYAPEGTGLELHEQYVPPGTSVSTSPWIIGRNKDLYGEDANSFRPERWL
EASPEEERRWDHFSFHFGYGARKCLANNFGLMQLYKVAAE
VFRRFEVKVEGSNEDTVSGGPPASARFRFD
RRARSWS 1413728
>CYP5109A1 Aspergillus flavus
GenEMBL AAIH01001109.1 NRRL3357
4670-6495, only 3 aa diffs
AFL2G_08515, gene model is revised
MSPFIFAVTLTFAILALGILRRRYFHPLSRFPGPFLGSVTSLYQTYWHVHPNKTLHDTELHRKY
(1)
GPIVRYSPNGLIVNDPALLPVIYNRRANKTDFYAPVFDTHSTFTRKDYREHVASRKAISHAYSVTNTRLFEPQVDG
ILSELISLLSESATEKRLVDIMEYGS (2)
WFTYDVTSLFVCGKPFGFVEKRTDVKGLIQNKNKVLFIVFIMTIQENLSWIVRN
TRLGRRYLMPHPTDQSGLGVVMAERDRIVDAVIDSDGKVKRHLLVKGSLLSSLMEILGTEGCPLSLVDVKAEIFFAMLAG
SSVTPSQLARVIFHISRNFKVQEKLYEELVAAEQDGRIPPLSAIISDEQAHRLPFLSACIREAQRYAPTMSQLPRYAPEG
TGLELHEQYVPPGTSVSTSPWIIGRNKDLYGEDANSFRPERWLEASPEEERRWDHFSFHFGYGARKCLANNFGLMQLYKVAAE
(0)
VFRRFEVKVEGSNEDTVSGGPPASARFRFDRRARSWS*
>CYP5110A1 Aspergillus oryzae
GenEMBL BAE58993.1 AP007157.1
gene
model revised
1141014
MAIQSTLEMCHLAESGVYLILVTFGVGLLFGLIVLTSDYLDGWLRRRALGDIPFVDEGSN 1140835
1140834 MSACLRWWSRKFDCDKEYAEAYKQ (0) 1140763
1140699
YSKTGKPYATRLKNNDHGIVLPLNSTKEWRTLPHDQLSFLHALSE (0) 1140565
1140509 FADLYMHTNITDRTPLHAVHYCNNTKTL (1)
SRFNRLMVDATDRALPLIVGKDTES (1)
EWKRANAFHTILSLCSTVAMSVLLGPEFSMDTSLIQTIM
MYNTAIMPSCAK
RTSYPRILRPFVWRLSPLCRAVKSDLLKTK IKLIPEIKHRIDIARSKKWWLEEGPMSLLDGLIETAFEKG
CLSRSSDRGDDDQQVALLAEEIIFYHFELSMPVVFFIIFAVYVIMNNKEYLTPLREEISEALKLSGGSFT
LDTLNHAPKLASFVKETCRLYDISCCN (2)
FRRVMKPIHLESINLSLKPG TIIMAPGRDVHLDPDYYDNPTTFNGYRFYD
ASRGTCTPHISTTSPTFLTFSHGISACPARVLATQITRTIFIMFLLKFDVELAHEEMPAYGFANGPAYLP
NPSVMIRVRPCQKDVLGV 1139078
>CYP5110A1 Aspergillus flavus
97% to CYP5110A1 Aspergillus oryzae
AFL2G_04288
MAIQSTLEMCHLAESGVYLILVTFGVGLLFGLIVLTSDYLDGWLRRRALGDIPFVDEGSN
MSACLRWWSRKFDCEKEYAEAYKQ
YSKTGKPYATRLKNNDHGIVLPLNSTKEWRTLPHDQLSFLHALSE
(0)
FADLYMHINMTDRTPLQAVHYCNNTKTL (1)
SRFNRLMVDATDRALPLIVGKDTES
EWKRANAFHTILSLCSTVAMSVLLGPEFSMDTSLIQTIM
MYNTAIMPSCAK
RTSYPRILRPFVWRLSPLCRAMKSDLTKTK
IKLTPEIKHRIDIARSKKGWLEEGPMSLLDGLIETAFEKGCLSRSSDRGDDDQQVA
LLAEEIIFYHFELSTPVAFFIIFAVYVIMNNKEYSTPLREEISEALKLSGGSFTLDTLNHAPKLASFVKETCRLYDISCCN
FRRVMKPIHLESINLSLKPG
TIIMAPGRDVHLDPDYYDNPTTFNGYRFYDASRGTCTPHISTTSPTFLTFSHGISACPARVLATQITRTIFIMFLLKFDV
ELAHEEMPAYGFANGPAYLPNPSVMMRVRPCQKDVLGV
>CYP5110A2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000022.1
55% to
CYP5110A1
ACLA_043300
MAVQASSSIHHLADLGTSAALTGVVLVLLCGLLIVISDYLDGWQQRRALKGIPIVDEG
SYMRPLLRWKRFDAAKEYARAYHL
(0)
YSKNGQPYATRLQNDDYGIVMPLNSAKEWRALPHEELSFLHALAE (0)
FVDMNLYSDVTDRTPIQAVHSCNNTQSL (1)
NHLNKLLVRNIDNVLPSIFKQPTQD (1)
165619
KWLEVNTFQTIMSLCSTVTMSLLLGPDTPYDPVLHHHVSSFGAAIMESCYGRTAYPRILR 165798
165799
PFAWRFSPQCRGLRTHLSMARARLIPEVARRVAAARKANIEVKDSRPTSLLDALIEAALE 165978
165979
NGSLNRDGICTNEKAQLQILADDLLFFHFELSKPTTVNIVFQMYAIMNHREYMSPLREEI 166158
166159
TKALELTNGEWTVETLKYAPKLESFTKETFRLYDISPCN (2) 166275
166335
FRRVMKPVTLKSIDLSLRPGTILVSPCRDIHQDPDFYENPMTFDGYRFYDTNSNACTPRV 166514
166515
ATTSLTFLSFSHGTGSCPARVLASQICRTIFIKFLVEYDVELANKKMPAYGFTNGPVFLP 166694
166695
NPEVMMRIRPRGNGMQ* 166745
>CYP5110A3 Aspergillus niger
fgenesh1_pg.C_scaffold_22000006|Aspni1
71% to CYP5110A2
MAVHVPFSIHHVVDIGISTGPVVIVLVLLFGLAVVGSDSLDGWWQKRALRGIPIVDEGSYMRPKLRWKRFDAEKEYARAY
QQSAALSLRDAQFADMNMYCDVTDRTPIEAVHSCNNAESLNILNKLLARETDTALSQIFEQPTGKDWKELNTLQTILSLC
STVTMALLLGPDTAPDPVLHHHSTSFGEAIMSSCYRRTGYPRILRPFVWRFSSECRNLRKHLSLVRERLVPEVARRVAAA
RAADKTKDVRPSSLLDALIAAAFDNGSLSPDDQGRNDAAQVQLLADDLIFYHFELCKPTAFNIIFQLYAIMDHPEYKAPL
REEALQALKLTNGDWTVETLKHAPKLESFTKETFRLYDISGFVSFRRVMKPLTLNSIGLSLRPGTILLSPCRNVHLDPEI
YEDPTTFNGYRFYDSSREVCSPRVATTSLTFLTFSHGAGSCPARVLATQICRTIFIKFLLQYDVEPVQKEILPYGFTSGP
VYMPNPSVMMRIRPRSDGK*
>CYP5111A1 Aspergillus oryzae
GenEMBL BAE58483.1, AP007155.1
Note a 6 bp micro exon matches known mRNA
EY432550.1
3848877
MLQDLIATLASGAQMYWASSGVWMRVVLTVSAIWIFWRIWRFTILPLFRPNEPVELPYWIP (1)
YF (1)
GHAGAFFKDSHQLIRTAL (2)
KRFGTLEPFSMIIAGDRYYVITSPEDTRPFFADVKAMTTDGFLDRALL
AFGCAPERLHTLWQRNTPTKVNPKGKNLIHLTQDLFKHDLVPGPTLNVLLERYQGALDELLSWDRLVGAY
PSLVSTQTEAISLYDICADFIANANQIVLFDRALLAIDPDMAVEMRTFTDELWKLVHRSRLVDTTEVTRI
LRQYSSAFKSYLQLPPEARPNETPVIRTLLETYAELGIHEDDRAAMLVMICWAGDANAYKAAYWVLAYIL
YDPQLREIIRQETAPAVGPDGKLDWPYLAKRCPRLSSIYHEVLRLTKRDVIVRQVVRDTALAGKRLRKDS
IAVIPTCQLHDNPDTYGADAASFNPDRFLKQPGLAQTTFFPYGGGRHYCPGRYFVEMEIYGLVALMLNRY
EMDLAWAAPFPRRDESLVTLGISRPVPGDDLHVTLNWKEGNKN
3850672
>CYP5111A1 Aspergillus flavus
100% to CYP5111A1 Aspergillus oryzae
AFL2G_01649
MLQDLIATLASGAQMYWASSGVWMRVVLTVSAIWIFWRIWRFTILPLFRPNEPVELPYWIP (1)
YF (1)
GHAGAFFKDSHQLIRTAL (2)
KRFGTLEPFSMIIAGDRYYVITSPEDTRPFFADVKAMTTDGFLDRALLAFGCAPERLHTLWQRNTPTKVNPKGKNLIHL
TQDLFKHDLVPGPTLNVLLERYQGALDELLSWDRLVGAYPSLVSTQTEAISLYDICADFIANANQIVLFDRALLAIDPDM
AVEMRTFTDELWKLVHRSRLVDTTEVTRILRQYSSAFKSYLQLPPEARPNETPVIRTLLETYAELGIHEDDRAAMLVMIC
WAGDANAYKAAYWVLAYILYDPQLREIIRQETAPAVGPDGKLDWPYLAKRCPRLSSIYHEVLRLTKRDVIVRQVVRDTAL
AGKRLRKDSIAVIPTCQLHDNPDTYGADAASFNPDRFLKQPGLAQTTFFPYGGGRHYCPGRYFVEMEIYGLVALMLNRYE
MDLAWAAPFPRRDESLVTLGISRPVPGDDLHVTLNWKEGNKN*
>CYP5112A1 Aspergillus oryzae
GenEMBL BAE57727.1, AP007155.1
35% to
551A1, 34% to 551B1, 32% to 551A2
1498000 MNTSLDSSTALGFYITLTVVTISVAYVSILALCRLFLSPIAVFPGPPLARLTYLTQWYYDWVKDGQYYLQ
IEEMHKKYGPIVRVTPGELHIRDSNFHSKLYVTGAVRKSDSYHRFTQGTGFEDITFPLLSHDRHRALRGQ
VSRLFTRAGVRQHESRIVARIHVLSQRMCGFMSNGKPVNLHDAFSSLAAGMYNAISVIFHEEPTDYLGDP
EFNTAWYNTLKMGTATIPLLTQLPWLARVISAPVARYILERATPWRIFDDKSRRQMLKSKSRPTIASSDR
SNATVFDNLFKDNLFYTMNEQTFTRSAQ (0) 1496760
LIQQGAVHNVSLSLAMTIYCLLCQPDEQEKLTRELESSFSKYPERSPSFSELESLPHLSACIKEGLR
()
LSVGALVGIPRVSPDVDLVFDTYTIPKG ()
TPVSMTPHWMHMDPDVFPNPNSFDPSRWSSTLTEPEKLSLMGRYFVPFGKGSRSCIG
()
TRLAYLLLYQTLAHLFRPGAPRLLLHETDISDVTPVRGFLFSL
PKKDSKGLRVILVNDSESTNRM* 1495794
>CYP5112A1P Aspergillus flavus
97% to CYP5112A1 Aspergillus oryzae
NTSLDSSTALGFYITLTVVTISVAYVSILA
TPVSMTPH*MHMDPDVFPNPNSFEPSRWSSTLTEPEKLSLMGRYFVPFGKGSRSCI
GTRLAYLLLYQTLAHLFRPGAPRLLLHETDISDVTPVRGFLFSL
PKEDSKGLRVIL
>CYP5113A1 Aspergillus oryzae
GenEMBL BAE62292.1 AP007164.1
Revised model
only
top part = P450 C-term,
36% to
584E1, 36% to 584A1 , 35% to 584B1
35% to
584C1, 40% to 584E5, 38% to 584G1, 32% to 584D1,
32% to
584D2, 41% to 584E3
revised,
gc boundary at CVG
MTAETGFVPTVFSLPSESAYSWVW
AVSAGLVAIFVLYLTQGIARRRFAYAHGCQAPPRYAHRDPILGLDSLRDSMQAR
KSDRYFRREQQLHQAYGNTFMSLLLGSWMVNTIEPKNLEVLFSTKFADYEVGFRRRNAFA
PLFGKSIFQSDGTRWQTLRSQLQLCFSRVQTSQLGLLESHCQRLLAALPSDNQKFDLALF
LHRFAADVSTDFLFGESINSLENPQNLDGGALKAFADTHSTCELRWLLGSMSWIWP
QRTFMKNVRLTHRFIQRYVDAALEREVTPPGKASDQQNEQRILFIDQLRQRTQDPIALR
DELTTLYFAGTDAPAALLINLFFVFSKRPDVWDRVRSEVQSLGGKAPDLQQLKGLRYVQD
CIREC (1)
LRLYPPQ
1582777 PSNSRVAVRDTVLPTGGGPDGGSPVLVPKGMMVHLSVYALHHRKDLWGEDADEFRPERWSYEKQTW
(0) 1582974
1583043 KYIPFLGGPRNCVG (1) 1583087
MDFGLNEVAYAVVRMAQNFQTITSVDPDEWVEGSSIALESKNGVKVVMCRDA*
>CYP5113A1 Aspergillus flavus
99% to CYP5113A1 Aspergillus oryzae
AFL2G_06213
MTAETGFVPTVFSLPSESAYSWVWAVSAGLVAIFVLYLTQGIARRRFAYAHGCQAPPRYAHRDPILGLDSLRDSMQARKS
DRYFRREQQLHQAYGNTFMSLLLGSWMVNTIEPKNLEVLFSTKFADYEVGFRRRNAFAPLFGKSIFQSDGARWQTLRSQL
QLCFSRVQTSQLGLLESHCQRLLAALPPDNQKFDLALFLHRFAADVSTDFLFGESINSLENPQNLDSGALKAFADTHSTC
ELRWLLGSMSWIWPQRTFMKNVRLTHRFIQRYVDAALQREVTPPGKASDQQNEQRILFIDQLRQRTQDPIALRDELTTLY
FAGTDAPAALLINLFFVFSKRPDVWDRVRSEVQSLGGKAPDLQQLKGLRYVQDCIRECLRLYPPQPSNSRVAVRDTVLPT
GGGPDGGSPVLVPKGMMVHLSVYALHHRKDLWGEDADEFRPERWSYEKQTWKYIPFLGGPRNCVG
(1)
MDFGLNEVAYAVVRMAQNFQTITSVDPDEWVEGSSIALESKNGVKVVMCRDA*
>CYP5114A1 Aspergillus oryzae
GenEMBL BAE63475.1, AP007167.1
33% to
548D2, 33% to 548E2, 35% to 548F1, 37% to 548G1,
38% to
548A6, 41% to CYP548H1
657999
MELPIRYCLGISLAVAGVAFCLYQMFFHPLAKYPGPTLAKFTAARAAYCAWKDDVHLDIWLCRKKY
GPIIRYVPNHLCFDTVTGLK DIYLSGKDLRKDKIMGKASFVPNLLTIMDRKEHARHRRLIGIGFSQSAMKSVNE
RLLHHVKSFYHVAYNAGLPDEANGWSHPLTMSDLCSYLTFNV MADFIYGKSYDLIHCPDYRHLLEHIEES
NLRTGVLLYCPQLYIGRLDRKLFPRASTGNKTIHSFINQIIQERKSENGVGQSIYEQLGTQRKSTDHPLT
PEEIRSEAMLLTIAGNDTTSTALCAALFYLGKNLHAYEKLAAEIRTKFSVVDGIGQDETLRNCHYLHACT
YESLRMSPPVGSSMWREVGPGGTSIDGEFIPCGYGVGTGIYSIHHNPKYFPRPHDFIPERWLSEKDGFIC
KEQADIPFAAYILFSAGTRACLGRHLAITELLTTIAALVLLYDFRISHTENGELGCGHALGRHGRTNPGE
FQLYHRVTSGKEGPILQLRPRKGN 656192
>CYP5114A1 Aspergillus flavus
100% to CYP5114A1 Aspergillus oryzae
AFL2G_11037
MELPIRYCLGISLAVA (0)
GVAFCLYQMFFHPLAKYPGPTLAKFTAARAAYCAWKDDVHLDIWLCRKKY
(1)
GPIIRYVPNHLCFDTVTGLK (1)
DIYLSGKDLRKDKIMGKASFVPNLLTIMDRKEHARHRRLIGIGFSQSAMKSVNERLLHHVKSFYHVAYNAGLPDEANGWSHPLTMSDLCSYLTFNV
MADFIYGKSYDLIHCPDYRHLLEHIEESNLRTGVLLYCPQLYIGRLDRKLFPRASTGNKTIHSFINQIIQERKSENGVGQ
SIYEQLGTQRKSTDHPLTPEEIRSEAMLLTIAGNDTTSTALCAALFYLGKNLHAYEKLAAEIRTKFSVVDGIGQDETLRN
CHYLHACTYESLRMSPPVGSSMWREVGPGGTSIDGEFIPCGYGVGTGIYSIHHNPKYFPRPHDFIPERWLSEKDGFICKE
QADIPFAAYILFSAGTRACLGRHLAITELLTTIAALVLLYDFRISHTENGELGCGHALGRHGRTNPGEFQLYHRVTSGKE
GPILQLRPRKGN
>CYP5115A1 # Phaeosphaeria nodorum SN15
Name changed to CYP548K1
>CYP5116A1 Aspergillus oryzae
GenEMBL BAE54596.1 AP007150.1
This
P450 is unlike any other, very low seq similarity
240943
MSLFLVIVVVLLLFLSSPLHRLVHIGLKKPVSPNIDPETYRRIIEGKGLYQEVHNQLNARQSRAIPNKRL
RAVFGIENALTTDNEMHAKRFLRQAKGLINLSPTSWESLSGLVRSAARRSIDGA
MANSPDKPRVMLTNLV
QVLVLRVVLSVLFRMETEALEVPDHDLLRLAEAINDAWTSSKDKTHLVSFQDNISLQNSLKTVFPHLNCL
DPQGNPLNLVIPGFETMWRIVLRLFIEISYTSGLYHPEWRGIMTTFAIAPTKDEFERRNGKQNLSAEMLV
NEALRLYPPTKRVYRAFLPVGSDTVEVLNADIEKAQTATHIWGSDAEVFAPGRWGALTPQQKLAFF
PFGSKPFVCPAQAAFGPRAIALVV GALLVELGGEWSLCVGAECTEALVPGVRLSNQRTEYRDLCLARAGPV
242193
>CYP5116A1 Aspergillus flavus
99% to CYP5116A1 Aspergillus oryzae
AFL2G_10567 revised
MSLFLVIVVVLLLFLSSPLHRLVHIGLKKPVSPNIDPETYRRIIEGKGLYQEVHNQLNARQSRAIPNKRL
RAVFGIENALTTDNEIHAKRFLRQVKGLINLSPTSWESLSGLVRSAARRSIDGA
MANSPDKPRVMLTNLVQVLVLRVVLSVLFRMETEALEIPDHDLLRLAEAINDAWTSSKDKTHLVSFQDNISLQNSLKTLF
PHLNCLDPQENPLNLVIPGFETMWRIVLRLFIEISYTSGLYHPEWRGIMTTFAIAPTKDEFERRNGKQNLSAEMLVNEAL
RLYPPTKRVYRAFLPVGSDTVEVLNADIEKAQTATHIWGSDAEVFAPGRWGALTPQQKLAFFPFGSKPFVCPAQAAFGPR
AIALVVGALLVELGGEWSLCVGAECTEALVPGVRLSNQRTEYRDLCLARAGPV*
>CYP5116B1 Aspergillus nidulans FGSC A4
GenEMBL AACD01000061.1
New,
not in known collection
39% to
5116A1
363827
MTARSMASTVSLYLILFVLFVLFYRRCYRSSKKPAEFRTTAECRAIIDGSQFPDARKNQLTRL 363639
363638
EARALPNQPLIGAFGIKNAFTTGNEAEAKDFVENVRRLIEVSAVDWHGLAGALQCMLESI 363459
363458
IEENRDGARVKVSLTPTVQALVLRESFWILFQMGEDAHLEFKQLADLGKITNS 363300
363299
TWVRMKEERALEFKDNIVLQACLTAVFANHKTDINILDPGSNPLKLILPSFETVWRIVL 363123
363122
RLFIVLHCHDNEDYKRALLEFVRDPTLTQFRLRPDNAVSVEFLVKEALRLYPPTRR 362955
362954
IRRAFQFPGSSPNNQISNIGRANVEACHLNEEVWGPDALEFMPARWSKMSSVQRRSFLAF 362775
362774
GGPPFLCPASHAFGPMVIGLLAGVMLDVFGKMNGYGKEWVLGSDDERDMSEVHSRERLRN 362595
362594
ERDAYGGLFLDLYSRRIDVSS*
>CYP5116C1 Trichophyton rubrum CHUV862.00
GenEMBL AJ883817.1 AJ883817
cDNA
45% to
CYP5116B1, 45% TO CYP5116A1
STSTRHSSHHKCGTS
913
VVLTXFYAXLQTDVDKTQYKDVLKLAEDINRIWISSKSPDEEKRSSYQSETPFHDTLKAI 734
733
FPNTQISSPASNPLNLILPSFETMWRIVLRTFLEINFLTGNRSPEFKQVLVEFFHNPTKE 554
553
QFNQELSPGVSASNVISEALRLFPPTRRVHRHFQGLSSNERTLFAADIEACHRNLRVWG 377
376
SDALKFVPGRWNCLNEQQKSSFMPFGSKPFLCPAKPVFGPRMIALLVGALLCHYTENWEL 197
SSVSGKYGINMVAEGEYLDRDACAQLYLVRDIRV*
>CYP5117A1 Aspergillus oryzae
GenEMBL BAE64915.1, AP007171.1
42% to
65E1
14
P450 genes and 2 pseudogenes on this contig
MNSISALFSAGGFQWILLSLSLAFIVVYSLFYLAVGLYNLYFHPLARYPGPLLGRASSLWYARSLARGTV
AQDTLKLHEKYGDVVRIAPDELSFIQPENWSAIYGHQLGKDYRELIKDPRYHDTVKPTPTILTGDWDEHT
FYRKILSNSFSEKSLKDQEHILHHFVDLFVQRLKETSAEGTRELNMTDQWNYLTFDVIGFLTYGEEFHCL
TSSKLHDWIEAMLCVAILMSLGQAARHLPFPFDKIYKQWAIPSNVKRQVALHRDLTEVAIPHIPIQYASA
YRLNSRKGDIPYSVLKEHANILTIGGSETTATLLAGATFHLGKNPPVLQKLATEIRTTFVNDGEITVARL
SECKYLLATVEECLRIYPPSPANHTRMVPKEGIVLNDQHIPGGIGVGMPMYAAFRASSNFTYPDRFAPER
WLGDPMYSKDKKGALQPFSFGPRNCLGRHLAYQEIKLALAKLVYHFDLELNPKCGDWDEQKNFTFWVKPP
LWVNLHPVKS
>CYP5117A2P Aspergillus clavatus
Pseudogene fragment
63% to 5117A1
(+) strand I-helix to EXXR motif
adjacent to a CYP68Q seq on the (-) strand
ACLA_064140
GATFYLATNTAIFPKLASEIRGTFASDEEITVARASKCNYLAATIEECLRMYPPT
>CYP5119A1 Aspergillus oryzae
GenEMBL BAE60008.1
35% to
5068A1, 34% to 5068A2
39% to
5068B1
MLPTLPNIAGRINTMATFLLPVAIGTIILLFLYGKYVTSTLIPGPPTLPLIGNLHQLPSDDRRHVLAQWH
KKHGPIISLKFGWSSVVILGNIAVTKELFGKRSLKYGSRPRMVMARDCMTKQMQTSTLPWGEKWKIHNRI
QLSLVGGPKIRSYQSLLDIESCKVLYQLLSTESLVTCFNRFKFNIIYTLAYGKDPDQNESDFHEILELAD
HFTQTLTNATWVVDLFPILNCLPRRLAPWKAVGDDFHRRAMGWFRRNSEAAVKSNSWNWTKHVQFNEDTG
NLSVSEMQYLIGVLFEAGVDSTATVLHFFVLACTLYPDAVTKARQELDKVVGSARLPTPKDLPQLPYVKA
FIQEVLRWRPITAEGLPHFTLEDDKYQGYDIPKGSTVIFNYWSGHMDEDTYQHADQFCPERWIERPDLPL
GVFGYGRRACAGRRLALMSLETLIPKLLWAFDFRSPAGTDHGKSRDPGTEHQGALIKPRSFPVSWHPVSN
DRRLIIERLFQERDKDLDTVLDDIGKAFERY
>CYP5120A1 Aspergillus terreus NIH2624
GenEMBL AAJN01000022.1
36% to
CYP5102A1
this
p450 belongs to a group of sequences without
Cys at heme region CYP5102, CYP5120,
CYP5121 families
Not
included in the Cytochrome P450 database in Korea 3/24/2009
33059
MVTLAIVVLFVLIASIRLLYNHVRLNTIPGPVLAGLSSFWLHAQPSSQLPNSLLQLHE 33232
33233
KYGTIVRIGPDLVSVSNPATIVLIYTRRSRNR (0) 33328
33462
YEGLVDPALRNLVHTLRRYQTLDLASFLHFFAADFLSRLTTLHPAGANNA 33611
33612
RRHEPTERGLPGFFAECLLLRGPISRLKRQHGCPFICREVRSHFTGQPTSISSRTLFK 33785
33786
SEDHPSPMEEHLDCIAKTFVSTFRFLLKYPAVMRKLRREIVAAHNHNNLSPLPLW 33950
33951
SELGELKYLQAVMKESLRLSHVHRVHEVKSPAGGVTVSGYYVPQGTTIRCHPLVVHNNA 34127
34128
QIYGDRPQVFDPERWLNNDLQRQKCMTECLMLFQQHVFENPTIYAAWWELKKAIVVVLMW 34307
34308
FN (0)
LELCTAYEAAQDSGTGSNPPVVVRFIPRS*
>CYP5120B1 Aspergillus nidulans FGSC A4
GenEMBL AACD01000093.1 new not in known set
this p450 belongs to a group of
sequences without
Cys at
heme region CYP5102, CYP5120, CYP5121 families
weakly
similar to CYP532
38% to
CYP5120A1
MVAWA
214086
VLLLAVVAATLLHLLYNYSRLKSVSGPILAAFTDAWRANAQRSSSSSEYGRLLKELHRKY 213907
213906
GVAVRLGPGFVSLSEVGDITRVYHTLLQDE (0)
213711
YESAADTAMRNLVHTVRRCRTVDMTTLLHFFADEVNTRLFWSACA 213577
213576
PSAASSASSRTHRIQPSFSFFATIEELVLRGPVALLKRERLSCYCLSGDVSAKIYGNE 213403
213402
LVLPTGPSATRKLAISAPDGLILAASIQIITKAFVSVFFFLLNNPLIMRRLR 213247
213246
QEIESIPRFRNRTKLPSSRDLGGLYYLDAVFKETMRLVILQSQPMEVRVTFESLYISSKH 213067
213066
VPRGTVLSWHPHVVLTNDAIYENNLYVFRPERWLTPNRQRQTLMEASLLPFMVCRIHYPK 212887
212886
LEAAWLLLKKTVVVLLREFCD (0) 212824
INLTQTEGQTVADGMELPPWSMVVDFIPRPATAEEYVGQLL*
>CYP5121A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000008.1 NFIA_060240 revised
42% to
AAKD02000042.1 Aspergillus clavatus
this
p450 belongs to a group of sequences without
Cys at
heme region CYP5102, CYP5120, CYP5121 families
1210404
MAVFAALLLLLCVFGGILWNYTRLNTIPGPLLAGLSDIWSQCLKSSPRYAYRLQRLHRKY 1210583
1210584
GEVVRIGPKTVSVTDPSNIFWLDAACPQRSK (0) 1210676
1210852
DLVLDFLKAIRKQRTMKLTVFRDFATDIVGRMFVGDLEDDRAAPMRTGSNQMDRCRFTTS 1211031
1211032
LDHIMFKNPVAKLKRKRNKSLRWVSCAVTHSRWDDASIFEVLPETGRKTFLQ 1211187
1211188
AETREYGGPYASLIVKGADCMVAAFVSVFRHLLKCPTAMSQLQHEVDNAFRNLTLSD 1211358
1211359
ILQQETELHALSFLDAVIKESMRLALRFDYLRDVPAGGLAVLGHYLPEGTVVQFHSEA 1211532
1211533
LRNNRTIFGEDVSDFRPQRWLQADLDQWQRKQMEALLFLRPNMPNSAKARAAWLELKRA 1211709
1211710
AALIILKFD (0) 1211736
1211784
LRPLNYEEVFIQDAVSREQEYEILVNFTPRMH*
1211882
>CYP5121A1 Aspergillus
fumigatus Af293
GenEMBL AAHF01000006.1
85% to
CYP5121A1 Neosartorya fischeri = ortholog
this p450 belongs to a group of
sequences without
Cys at
heme region CYP5102, CYP5120, CYP5121 families
Name
changed from CYP5121A2
2336635
MAVFAALLLILCVFGGILWNYTRLNTLPGPLLAVLSDIWSQCFKLSPGYAYRLERLH 2336805
2336806
RKYGEVVRIGPKTVSVSD 2336859
PSIVFWLDAACPQRSK
(0)
NLVL
2337098
NFLRAIRRQHTMKLTVFRNFATDIVGRMFVGDLGDDRAAPIGTRSNHIDRCRFTTSLD 2337271
2337272
HIMFKSPVAKLKRKRNKGLRWISCAGTYSRWNDASIVDVLPETGRKTILQAETRE 2337436
2337437
YDGPYDSLIVNGADCMAAAFVSMFRHLFKCPTAMFQLQDEVDNAFRNLTISDVLHQET 2337610
2337611
ELHALPFLDAVMKESMRLAMKFDYRRAVPAGGLAVLGHYVPERTVVQFHSEALRNNRT 2337784
2337785
TFGEDVSDFRPQRWLQADLDQWQRTRMEEALLFLRPNIPNSAEARAAWLELKRAAALIIW 2337964
2337965
KFD (0)
2338021
LHPLNYEEVFIQDAVSPEQEYEIMVNFTPRMH*
2338119
>CYP5121B1 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000042.1
42% to
AAKE02000008.1 Neosartorya fischeri
this
P450 belongs to a group of sequences without
Cys at
heme region CYP5102, CYP5120, CYP5121 families
ACLA_087460
MAAFG
82938
ILLSAVLVLGGVLLRNYVSLNTVRGPLLAGISNLWREFLQSAPEYGRRLESLHRKY 83105
83106
GQVVRVGPNTVSVSDPSLVAWIDLSDRGTVN (0) 83162
QLTSTFLRAVRKQRTINLAVFKLFAADIVQHM
83430
83431
CSNDIIQPRASQVPFATDPFIPTESSYVSSFLNSLLLKCPIAMLKHKRNGCLPI 83592
83593
CGFVPESVKRPNAYQPVAGEYQRSGNVSLVAIGVECMEATFASVFYFLSTH 83745
83746
PATLSRIKREIDTIFSMASFSEVLHQTKSYALPYVEAVMKETLRHVMIFDYQHQVPPG 83919
83920
GVMVGEYDLPQGTVIQYHADTIRHNSTTYGEDSALFRPERWLLADTTERKRMEEGLIPLR 84099
84100
ICFRNDSQTRAAWRSLKMIIALVISKFD (0) 84183
LQLSCEETPDNTSSTMSCNVLVTFAPRLP*
>CYP5125A1 Aspergillus nidulans
Genome gene number AN8437.3, 34% to XP_755777.1 Aspergillus fumigatus
34% to Chaetomium globosum CYP5127A1 XM_001227760,
34% to NW_001509762.1 Neosartorya fischeri
MEITAYFCGALLLLLWYRVCARQSVDKTQVQLRQNIIL (0)
VKNTPYAIPTPEAYQVHFSSATHIKQLIQAPDTHLSLHALAKD
(0)
MFQPTHTMDGLAVDDCMSANGT
IHQRALQAELRSHLPALTQPLSECIARTLTKEVSQASGSLAAVGDGWRALQL
FPLAKRLVVSANALTFFGPEVSSNPIFL
NAALEYPEHMMQTAEILRLLPS (2)
ALTVLLDTLIPIIERRLYEHQSRPEQAEARVPRDCIQFFVNAV
KHKKQLDKWHAQRIVQVLLGIWFASVHQPAMCLFYALDDLCLHPEYVVPLREKISQAVQ
(0)
IDISTLPLLDAFLKESARLHPTDSISVRRKALRPFTFSDGTSLAKGDVACIPLQPALQNPESYANPLTFNPHR
(2)
FLKDKMTSTYIRSSRSRFTDADVAFPIWGLGKHACPGRHYASLLLKLVLAHVLLRYEIKLPDRNRRSEKRS
FYWRSAIVPRSGAVLYFRERGSCTE*
>CYP5126A1 # is the same seq as CYP5091A1
use the lower number
no sequence
>CYP5127A1 Chaetomium globosum CBS 148.51 (CHGG_09834)
GenEMBL XM_001227760 (my version is a revised sequence)
34% to CYP5125A1 A. nidulans,
36% to XP_755777.1 Aspergillus fumigatus
36% to NW_001509762.1 Neosartorya fischeri
MNTMNNTIAVKALGLQQTWPPASLLRVNPLAAVVVAGMLALLCLQACTSGNKLL
(0)
ANGEPYEVLAPDGRYVFVSSPKYIKEMDSAPDTVLSLQAAAKQ
MLQPIHTMHAFNWFDRRGTEGVGFVKALRTMLTNNLPAVLPDLSTIIRT
RFESLHEAHPKINGVTQSPVYVMNVKLVVLSNAVSFFGKDL (1)
AKNEAFMESALTYIEETFVCAEIVRLLPKFMSP (2)
ILGRLMRRRLKSQDVVYNTLLAVTEQRCLERDMKNLGQDVPYH
ADCIQWIMETSPRAKPWTPMRIVHELMAIWFGSVHAVHT (0)
TITFAIHDLCLHPEYVEPMRQELLAGYADFEKTGLGLPLMDSFIKESARITPVEA
(1)
QSTRRAALRPFTFSDGTKLNVGDWGC
TPVKAMMHDAEFYPEPLQFNGFRFADPAIVQAAGDHFKTPQPKPSKLTDCSSTYHVWG
TGRMACPGRYYATAVMKVILGQIIMNYHCELLNREESRCVTWRSTMLPKHSTKVVFTRRAD
>CYP5128A1 Aspergillus nidulans
Genome gene AN1703.3
Changed from AN1703.2; change type is EVIDENCE_CHANGED
Too short at C-term, N-term is wrong, revised
66% to 5128A2 Aspergillus terreus
50% to 5128B2 AAID01000197.1 Botryotinia fuckeliana B05.10 cont1.197
46% to AAGI01000270.1 Phaeosphaeria nodorum SN15 cont1.270 CYP5128B1
43% to AAGT01000426.1 Sclerotinia sclerotiorum CYP5128B3P
40% to AAIL01000498.1 Trichoderma reesei CYP5128C1
MSLIVLFIVILLSLIIRALYLLYR
HPLSSVPGPKLAACTSLWLAYHTYIGDECSTLFALHQRYGPVLRIAPNDVDI
ASGDAIEPIYLARGGFPKTPVYSKFDIDGHSTIFSTLTLPERASRAKAVAPLFSTASIRNSQERLLEVVDDFVDRLRQGA
QSGRPVNVLGLARAMAIDAVSAYLFQERYGALDENAEVMSASLFVDAYVGVGAFFNFVCGRVGEFLVGLVEYLTQLSGTA
KSFTAIDDYTSRLVRQAVPKSGSYQIRLLERVSLRQTQIEIKDVCFAGTDSTGMDVATIIWYLAKYPEK
(2)
YIKLRTALENN
PPDGDPLSTPYLRAVIREGLRLSWANPTRLPRSVPAGGWKYKSYSFPEGTSVGISAWQLHQEESIFPNPLSFDPERWLEP
NVTDDMLNNFFAFGKGTRACIAQNLGTAEVTLAIWKVVEKDMLRGAR
(0)
ILQWFNSRVKGEEILVQWIDR*
>CYP5128A2 Aspergillus terreus
GenEMBL XP_001210824.1, EAU39384.1
ATEG_00738.1
66% to AN1703.3 CYP5128A1
49% to AAGI01000270.1 Phaeosphaeria nodorum CYP5128B1
47% to AAID01000197.1 Botryotinia fuckeliana CYP5128B2
42% to AAGT01000426.1 Sclerotinia sclerotiorum CYP5128B3P
40% to AAIL01000498.1 Trichoderma reesei CYP5128C1
49% to AAIM02000125.1 Gibberella moniliformis partial seq CYP5128C3P
VDKEIQ may be an intron
1 MYKSLLERGP VVLGGFLLVL IAFCVCKSIY RVYF HPLSHV PGPKLAAATS LWLAYHTFIG
61 DECTTVSELH KRYGPVLRVA PNDIDIADGE AIEPIYLAHG GFPKTRAYSK
FDIDGHTTIF
121 SSLTLSERAT RAKAVAPLFS TASIRQSEQA
LGVVFDDFVA RTRREAQTGR PVNVLNATRC
181 MAIDAVSMYL FQKRYGAIDE GSKTMSASPF
VDAYVGVGAF FNLAHGKISD ALMRFIDRWN
241 TTQATETAFQ LMDAYTSQLV KTAVPKSGSY
QSRLLEREIS EELSQIELKD VCFAGTDSTG
301 MNMATIMWNL AKHPDVYARL RQELQDSAAR
DEDLTSCAYL RGVVREALRL SWANPTRLPR
361 AVPSGGWRFK DYFFPAGTSV GVAGFQLHQD
EEVFPEAQRF RPERWLQPTD AMLNNFFAFG
421 KGTRACIAQN LGTAELVWAT IKVVQADLLR GARI
VDKEIQ
ILEWFNSRVK GEKILIQFDVQS
>CYP5128A3 Aspergillus niger
estExt_GeneWisePlus.C_70180|Aspni1
69% to CYP5128A2
MAHIENLQGLIAQSLLLAAFAIVSAIFCRCFYRIYLHPLSSVPGPKLAACTSLWLAYHTYIGDECTVVCDLHRKYGAVLR
VAPNDVDIADKDALEPIYIARGGFPKTPAYSKFDIDGHTTIFSSLTLPERATRAKAVAPLFSTASIRSSQEALREVFDDF
AKRLQAEARTGRPVNVLNVTRAMAIDAVTTYLFHERYGAITEKTESMSASPFVDSFAGVGAFFNIVPGKIGDFVMEVIER
WSTTKNVEQSHGLIDQYNRRLIQTAIPKSGSYQSRLLEKSTIAQSQIELKDVCFAGTDSTGMNTATILWYLAKHPEIYDR
>CYP5128B1 Phaeosphaeria nodorum SN15 cont1.270
GenEMBL AAGI01000270.1 (WGS section)
67% to AAID01000197.1 Botryotinia fuckeliana CYP5128B2
60% to AAGT01000426.1 Sclerotinia sclerotiorum CYP5128B3P
47% to AN1703.3 CYP5128A1
49% to A. terreus CYP5128A2
44% to AAIL01000498.1 Trichoderma reesei CYP5128C1
52% to AAIM02000125.1 Gibberella moniliformis partial seq CYP5128C3P
30% to 532C2
VEIYE = intron?
MLTILLTPLALLLVRSLYRIFAHPLSHIQGP
LLPKITSLWLHYHAYIGDEASVIHELHAYYGPLVRVSPNEVDISDADAIQPIYVSKGGFP
KADCYANFDIDGHKTIFSTTDHDHRAARAKAVMPLFSTKALRENESAIWACVDRMIERLK
SESKSKRPVNVLNLTRSLAVDAVSTHLFRENYDGVSEQGPTLSVSAFVDAFVAVGRFFYL
PNVLFVWLEWAITKWQADRETDDSMTLVDKFVSNLVANTTPKSLTYPGRLLAVGISDSEV
KAQCKDLVFAGTDSTGMNLATIMRSLAVYPDKYERLKKEVDENIARGSDAQEVQALPYLN
AVVKEALRISMANPTRLPHVVPAGGWTFKEFCFPATSIVGCSGYELHFNAKIFPDPTAFV
PERWLEPTEEMSKYWFAFGAGSRACIARNLATLELQFATERLARSGVLDGAKAVQDK
VEIYE
WFNSKVKGEKIELMWG*
>CYP5128B2 Botryotinia fuckeliana B05.10 cont1.197
GenEMBL AAID01000197.1 (WGS section)
75% to AAGT01000426.1 Sclerotinia sclerotiorum
67% to P. nodorum AAGI01000270,
47% to A. terreus,
50% to AN1703
42% to AAIL01000498.1
Trichoderma reesei
50% to AAIM02000125.1
Gibberella moniliformis partial seq
MALLEQVSGLLTTNPLIVLVTITTLSLLFRSTYRCTLHPLSHIPGPLLPKL
TSLWLHYHAYIGDEASCIHRLHNQYGPIVRVSPSEIDIADADAIAPIYISKGGFPKAPCY
ANFDVDGHKTIFSTTDAEFRAPRAKAVMPLFSTKSIRDNEVALYGCVENMVGRMKEDAEG
GAPVNCLNLARSLALDAISTHLFSENYNGTSEKGERLSASAFVDAFVAVGRFFYLPNAVF
IWLSWFVEKLVMDSHTENSIKLVDQFVENLVESTPKESNNYPGRLLNTGFSKSEVKSSCK
DLMFAGTDSTGMNMATILRYLVLCPEK (2)
YEILRTEIMGNANSTTKQEIQALPYLSAVVKEGLRISMANPTRLPHVVPIGGWTFKSVY
FPAGSIVGCSAYELHFNQDVFPNPHEFEPERWLEG
13108
NITPEANKYWFAFGAGSRACIARNLATVELYMAVEKVVESDVLRGAR (0)
IFEWFNSSVKGEKLELIWNRNEKR* 13345
>CYP5128B3P Sclerotinia sclerotiorum 1980 cont1.426 pseudogene
GenEMBL AAGT01000426.1 (WGS section)
75% to AAID01000197.1 Botryotinia fuckeliana
60% to P. nodorum AAGI01000270
47% to Gibberella moniliformis
43% to AN1703
42% to A. terreus
1680 LLENPRSQKTTDPLTILLTTLTLFLLL
1598 STYHCTLL
1573
PLPHIPGTFLPKLTSL*LHYHAYTGNEASTIHKLHAQHDAIIRVSLSEIDIADADAITPI 1394
1393
YITKGRFPKAPCYANFNVDRYKTIFSTTDVEFRAARAKAVMSLFSTKCINLRDNEIALYR 1214
1213 CVNNMVRRMREEAKE*KQLNCLNLTWSLA
1127 LDAISVHLFLENYNGTLEKGERLSASAFVGAFFAVGRLF
1011
FYLPSTVFVWLSWFMEKLVMDSHTQNSIKLADQPVDNLVES
888 TPKQSQNYPRRLLNIKSEVKAHCKDLIFAGTDSTNMNLATIFRQLFLCLEK 736
YEILCA*IMENVNS 632
621 K*EIQTLPYLDLSAVVKEDLCISMANPTRLPHVVPTGGWTFKSVYFPARTIIGCSAYELH
442
441 FNAEVFPNPYEFQSERWLEGNV 376
6194
TAEANEYWFAFGAGSRACIARNLAMVELLTAIEKVVENDVLRGAR (0)
IFEWFNSSFKGEKMELICS* 5979
>CYP5128C1 Trichoderma reesei QM9414
Treesei_Cont498
GenEMBL AAIL01000498.1 (WGS section)
63% to AAIM02000125.1 Gibberella moniliformis partial seq
48% to AAJI01000647.1 Ajellomyces capsulatus partial seq
44% to AAGI01000270.1 Phaeosphaeria nodorum
42% to AAID01000197.1 Botryotinia fuckeliana
40% to Aspergillus
terreus
MAAHATVTANLLASLSPLTIGLSVVSILLLKAAHGLTTDRLRHIPGPLIARLTPIWYWYIV
WRGIECRAIAVLHKKYGPVVRIAPNEIDISDGAAVAPIYIDNGGFLKHPAYRNFDINGFP
TIFSVTDHAHRAVRAKAVAPLFAQQAINNSKPAMRRIIDTTLSGLERRKSLANGKPVDLL
DLFRCMAMDVMTEYLVGECFHSVGSKRLSVAGFVDGFVAAGRFFYLPTRLFTLFEYCASR
LNKSQALITASIDTVQSFATKVVDDSIARGEKATYQGRLLKAGISREEAIAQVIDIMFAG
TDGMARVLAVFCWHMARAPEK (2)
YDRARKEILQYPDTDARSLPYLSGAVKEAARLALANPTRLARIVPSGGLKVPGLP
SIPAGTSVGIGAYALHLNPDVFPTPYDFLPERWLEC
22767
TPEMLRDSFYFGKGSRQCIARNFASAIVWWGAEALVRNRVLDGAKP
IVEWFNSKQVGENIELTWQ* 22552
>CYP5128C2 Histoplasma
capsulatum Nam1 teleomorph: Ajellomyces capsulatus
Supercontig 1: 6516655-6517422 (+),cont1.647
GenEMBL AAJI01000647.1 (WGS section)
48% to AAIL01000498.1 Trichoderma reesei, runs off the end
39% to AAGI01000270.1|
Phaeosphaeria nodorum
40% to AAID01000197.1
Botryotinia fuckeliana
41% to AN1703.3
38% to Aspergillus
terreus
HCB01869.1 3 aa diffs to CYP5128C4, 5128C5,
5128C6
5 aa diffs to CYP5128C2
MATGIVATAHNAFPSPPSIPI
STTVVVVVVVVPVVLLLVKLHTDSLRYIPGPLIARLTPLWLWTLTHRGIECRLAAL
HSRYGPAVRIAPNEVDLSDAAALYPLCAKNGGCAKNPVYANYDIDGFATIFSAVDPVQRA
AKAAAVAPLFAQRAIVEGRELGARRAVAHGAPIDVLDLFRYLAIDVVS
LYLFGESFGGLGSKAPLAAMPFVDAFAAGGRFFYVPGWLFRHVDHWAGKFEKGARSIAAS
TAVVKEFAARV (sequence gap)
>CYP5182C2 Histoplasma capsulatum G186AR
teleomorph: Ajellomyces capsulatus
Supercontig 4: 1885071- 1886719 +
MATGILATALHAFPSPLSIPISATVVVVVVVPAVLLLVKLHT
DPLRHIPGPLIARLTPLWLWTLTHRGIECRTLAALHSRHGPAVRIAPNEVDLSDGAALYP
LYAKNGGCAKNPVYANYDIDGFATIFSAVDAVQRATRARAVAPLFAQRAIVEGRPTMQAV
VDAAVAELGARRAVAHGAPIDVLDLFRCLAIDVVSLYLFGESFGGLGSKAPLAATPFVDA
FAAGGRFFYVPGWLLRHVDHWAGKFEKGPGSIAASTAVVKEFAARVVDRSIAGEKAGVAQ
TSTYQGRLLRAGISREETIAQVLDVMFAGTDGIAMTMSVLCWNLARLPD
(2)
RYTRARHELLNNPSPLNGQSLPYLTAI
VKESLRLSMANPTRLPRIVGAEGLHVPGLPTLPAGTSVGLGAYVLHHDPAVFPQPREFMP
ERWLACTPEMLRNSVPFGVGARMCIARNLAVAVLRWT
AEALIRADVLGKNNNIHDGGVGD
GVRGVVQDGIEIMEWFNAKVVAGKIEIY*
>CYP5182C2 Histoplasma capsulatum H143
teleomorph: Ajellomyces capsulatus
Supercontig 4: 1916858-1918502 +
MATGILATALHAFPSPLYIPISATVVVVVVPAVLLLLKLHTDPL
RHIPGPLIARLTPLWLWTLTHRGIECRTLAALHSRHGPAVRIAPNEVDLSDGAALYPLYA
KNGGCAKNPVYANYDIDGFATIFSAVDPMQRAARARAVVPLFAQRAIVEGRPTMQAVVDA
AVAELGARRAVAHGAPIDVLDLFRCLAIDVVSLYLFGESFGGLGSKAPLAATPFVDAFAA
GGRFFYVPGWLLRHVDHWAGKFEKGAGSIAASTAVVKEFAARVVDRSISGEKAGVAQTST
YQGRLLRAGISREETIAQVLDVIFAGTDGIAMTMSVLCWNLARLPDR
(2)
YARARHELLNNPSPLNGQSLPYLTAIVKESLRLSMANPTRLPR
IVGAEGLHVPGLPTLPAGTSVGLGAYVLHHDPAVFPQPREFMPERWLACTPEMLRNSIPF
GVGARMCIARNLAVAVLQWTAEALIRADVLGKNNNIHDGGVGDGVRGVVQDGIEIMEWFN
AKVVAGKIEIY*
>CYP5182C2 Histoplasma capsulatum H88
teleomorph: Ajellomyces capsulatus
Supercontig 2: 3175396- 3177043 +
MATGILATALHAFPSPLYIPISATVVVVVVVPAVLLLLKLHTDP
LRHIPGPLIARLTPLWLWTLTHRGIECRTLAALHSRHGPAVRIAPNEVDLSDGAALYPLY
AKNGGCAKNPVYANYDIDGFATIFSAVDPMQRAARARAVVPLFAQRAIVEGRPTMQAVVD
AAVAELGARRAVAHGAPIDVLDLFRCLAIDVVSLYLFGESFGGLGSKAPLAATPFVDAFA
AGGRFFYVPGWLLRHVDHWAGKFEKGAGSIAASTAVVKEFAARVVDRSISGEKAGVAQTS
TYQGRLLRAGISREETIAQVLDVIFAGTDGIAMTMSVLCWNLARLPR
(2)
YARARHELLNNPSPLNGQSLPYLTAIVKESLRLSMANPTRLPR
IVGAEGLHVPGLPTLPAGASVGLGAYVLHHDPAVFPQPREFMPERWLACTPEMLRNSIPF
GVGARMCIARNLAVAVLQWTAEALIRADVLGKNNNIHDGGVGDGVRGVVQDGIEIMEWFN
AKVVAGKIEIY
>CYP5128C3P Gibberella moniliformis 7600 chromosome 9 cont3.125
GenEMBL AAIM02000125.1 (WGS section)
probable pseudogene,
63% to AAIL01000498.1 Trichoderma reesei
49% to Aspergillus
terreus
50% to AAID01000197.1
Botryotinia fuckeliana
52% to AAGI01000270.1|
Phaeosphaeria nodorum
44% to AN1703.3
47% to Sclerotinia sclerotiorum
43% to AAGI01000142.1
Phaeosphaeria nodorum
VKSPLCWNLAQLPKK
YDRIYKEVIENTELDAQSLPYLTRVV
KESLRLSMANPNRFPRIVPPGGMQVPV
LPNIPAGTSVGAGAFMLHHNPEVFPEPHQFMPERWL
463566
NPSQEMLRDSFYFGDGSRQCIARNLVSAGLWWAAEALIRSDVLRGAKV (0)
IVEWFNAKIVGEKI 463769
ELRCE
>CYP5128D1
e_gw1.7.775.1|Mycgr3 Mycosphaerella graminicola
43% to CYP5128B1 Phaeosphaeria
nodorum
44% to CYP5128B2 Botryotinia fuckeliana
MPIAHLALSVLAIWTIGCLSLTTYLDPLQSIPGPLKCRLTPLWSWYHSIIGDESRQIDALHKLYGPIVRISPNQVVIADG
RALAQIYSEKGGFLKAPFYENFDAEGHQTIFSARDPGYRGVRSRAVGQMFSVGAVKGGSKRIQGCIDEFVEKLEEEAGKN
GARVDVLRLARGLAINVVGAYLFGEEYGDLSDGTTMESAGAYVDFIVEIGRFFFLPPWLFQRVFASLSYFQPMASETEKS
IFKVDSFTRRLAERPIDANDGTYQGRLLKAGISVDEADVQMKDVVFAGTDTTALNLSNILWNLAKHPFIYAKLQAELAKT
PDNDSTYDAQRHPYLDGVIREGLRTLRANPTRFPRQVPPAGYVYTSPDGRTYRLASGTIVGISPSALHFNPAVFPDPQNF
QPERWLNPSSEMLRDWIPFGLGPRQCIARNLAMMELALAVKAVVRSGVLKDAKPVAGKIEIMEWFNARIMGGKVELVWT*
>CYP5129A1 Phaeosphaeria nodorum SN15 cont1.142
GenEMBL AAGI01000142.1 (WGS section)
no small intron, frameshift after LLAA
34% to CYP5128B2 AAID01000197.1 Botryotinia fuckeliana
MAFGTLLTLVACALFFRSLARIFVHPLRHVPGPIFA
STSSLFLYTICYLGVEGRVIRSLHHRYRSDVLRVGPNSVSIADSSALHDIYVSGGGFPKD
SRYSNFNLGPIVSIFSSTDTIYRDRRAKAVASLFAPNRLRSACEHDQVIGISVSRFIHLI
QEHKKERISFDLVDICARLSIDVVTEYLLGEPYGGFREIDHLSPRDQQYHKLSANPFIFA
IVAFSRFSLLPKWLFTRVYSLSTRLASDDEVKQSFRKLDSFISGVMSRLEDRPDHKADQT
YQSRLLAA
GIDPSEVAAQCKAVTFAGADSTA
VILTTIIFHLIVNPSICRILIAQLEAHQKASTGPLDPETVPYLRAVVKEGLRLGMANPTR
LTRVVPPSTALNVEGYAIPAGTVVGCAAYTLHHDPNVFPEPFEFKPERWIENRYDRNPLRLKMEM
54744
NMMPFGVGLRGCIGKNLAMRQLYETISAVCSTDTGLLEGARIKQQHIEVIEWFNGEIKGHRLDVHW 54941
>CYP5130A1P Aspergillus terreus
CH476602, NW_001471243.1
This
P450 is six genes away from MSAS polyketide synthase
6-methyl-salicylic acid synthase used in patulin synthesis
patulin is a mycotoxin sometimes found in apple juice.
32% to CYP65S1, 38% to 65AF1
This looks like a
pseudogene with stop and missing I-helix
ATEG_06281.1
117527
MGRARYETIKLLDTRDHREL 117586
117804 AITVYLGSVVYALYLHPLNKVPGP
KLYAIFRIPWIRDWLSRRLHVSVQRLHEKYGPIVRVAPDEVSFITAAAWNDVYGQKVA
KSLIRDGKWYANLTEGQEVIIVASEADHMRFRKIFGPAFGEKVLHESRSVIMSNIDLL
IAQLKHELKKTEGVADMVKWYNWTTFDIIGSL
VYGE*FGCLQGAEYHPGLK
VVLQNIRLSSYGALMERYSIFKRLVM
GLLPRHLLEMRNFHLTVIRDKIAWRSEKPRL
IPDESDLPLRATSPYRRGSWRP 118613
TSTSATALSAASYYL
118685 CRNQAAAQKLREEITTAFQSESDMCHD
TAVIREALRLYPPTPVGLPRRV 118831
118939 TVVYITQYSAYHSALNLRERNEFRPELWLGDPSYASDNLSVVQTFITGPYSCIGKSL
AYMEIGVVLAKMVWHFEWELSSSCCFEKEKVYALWQKSPMELRLRDLVSQ
119259
>CYP5131A1 Alternaria alternata
AB179766
AF-toxin biosynthesis gene cluster (Aft9-1,
Aft10-1, Aft11-1, Aft12-1, AftR-2, Aft3-2), complete cds.
31% to CYP548A2
This P450 is 2 genes from a PKS gene that is
47% identical to a PKS on chr 3 of Nectria haematococca
That PKS has no annotated P450s near it
MTYEKPDLKRTKATVSFKRIYLHRASEFPGPWLCQCSSIMAQYH
AWRGDLPRYLHVLHEKYGDFVRYAPNHVSIRHCDVWEDVYGFQRNVSKYDTTYSPFRL
APDFTSTWNTSNVDVHKSRRKLLNKLFSEQHLDDYGTLITVQVDEFMRQILEALPKDK
DVMAGPINFAYKSDVVAREIITSLVSGQTYGFQSGDAKSASLLADISKFERKLYLLGF
APWLKMLPSFKPTLALAQWIVQSSKQGLASGSKNTLVAKMLAARDEEKDVEFSRNDVI
ADARFFLLGGSVTSSSALSATLFFLLHHPVEMQELYDELRGIFPTYEDIKADAQLMRC
KRLRAVFEESMRLAPPVPTLLPRLVGPGGIKACGRYVPEGVVIGAPCWAISRDKRYFD
KPNVFKPDRWLADSSDPVALEKMLLATRASQPFSYGPRACPGRALAFRENGLLLAKLV
YAFEMEPVQDKSIVEESLTGICDGLVFNQLDTVGAHEVELMVRYRLRLDGKTKRRVSG
N
>CYP5132A1 AL115607.1 CNS01CJJ
Botrytis cinerea = Botryotinia fuckeliana
also = AAID01001229.1
30% to 670A1 36% to AACD01000002 Aspergillus nidulans new
family
8628
MALIPGHYLIAAAVSGIAAHLCAFIHGDWHLHIPQVIFTHCAGYALLLLRLRYQELSIIDSIQASTVLSA 8419
8418 CYLLFLFTSIIVYRVFFHRLRNFPGPRLAAATKLWSIWETRDSRNHLLMQRLFEQYGPIVRT
(1) 8233
8167 APNELTVFHPEGVELVKGGKNGTDQYNEKGVWYDLIHPKTSVVFNRNPSENAVRRRP
7997
7996 WDRAVSPAS (1) 7970
7916
SLRSYAANIVAPAAEVLEFVSNAQGEPVNINELMTGLIFDFMSVIVFGEVSSKTDAEEQIS 7734
7733 TLRRLKGALILLAPCGDSVWPALFAFNFLQFLKPVKSRLGLVESCRARMLKRMN
(0) 7572
7512 KKTSTVDVSGFFLKDFHDSAGETSLEKRENA 7421
7420 LLGNTISALVAGSDTARAAMIGIFYFLCKNPGNADEIYEELKDVDEKDSTVLA
7262
7261
GKPILNGFIKEALRVAPPSMTGLARIIGPQGLWIDNTFIPPGAQVTAPYYNSHR (1)
LPSAFQDPTEFIAERWTSRPDLIKDKRAYAPWGA (1)
6886 GQHICPGKALANVELRYVTALFVKTFKIKFAPGHDPEKFWTDMLDQVTMQPGEV
6725
6724 WCVFEPRN* 6698
>CYP5133A1 P450 on Fus oxys. AAHX01000914 32% to 639A1
new family
MAFLLLPILLLLLGTIYTRLQSRPHSHNDDSTKSPPQPSWGLQGLGHLLSLTLQPESFLTRLTY (0?)
23671 IYLAMPGKQIEGLFRRSSSLVPTPSLFDALTIFFGLSGRDIHIFNHDR
23528
23527
ISAYEASVGFYTDHPDVSRRIMEHQRQDFAHYLQGRNLVFVMERFKKNLASELSAASEIG 23348
23347
HDWGRIPDLFSFLSNLILRANVEALYGEHLLRICPTFCQDFWNFYKAFPNISKGLPRWL 23171
23170
VPSSYQARDEMHKNFDRWRTWCSENYNWDNDGLRDIEYEPIWGTQYVRKMIQRHEALGLS 22991
22990 NNGVAVVMLGYFF
22847
YSAMANTVPAALWMIVHILLDASLLRRVRHQISFAFQSTEVGEQPDIKVLMKDPLLNSIY 22668
22667
YETLRLRVASTVGRTCLDDQLCLAGGWKVKAGVPVMFTGWLAGLDVSCWNTGQDLSSGKP 22488
22487
QHPLEAFWAERFLDCPGSSSISGPAKKKRVQPARESPQRPTTHMGTEDERSRASVAGLRG 22308
22307 HFFPFGGGAFRCPGETLAKQVIFASVAMVLQSYDLRLIDPEEARKIEPGHRELPFGLHSF
22128
22127 DRPVPVEICKLSET* 22083
>CYP5133A1 Fusarium oxysporum
97% to CYP5133A1 on AAHX01000914 (10 aa diffs)
FOXG_06897, FOXG_16113, FOXG_14825, FOXG_16265
identical sequences
MAFLLLPILLLLLAREFLDTPHIEGLFRRSSSLVPTPSLFDALTIFFGLSGRDIHIFNHDRISAYEASVGFYTDHPDVSR
RIMEHQRQDFAHYLQGRNLVFVMERFKKNLASELSAASEVRHDWGRIPDLFSFLSNLILRANVEALYGEHLLRICPTFCQ
DFWNFYKAFPNISKGLPRWLVPSSYQARDEMHKNFDRWRTWCSENYNWDNDGLRDIEYEPIWGTQYVGKMIQRHEALGLS
NNGVAVVMLGYFFVAMANTVPAALWMIVHILLDASLLRRVRHQISPAFQSTEVGEQPDIKVLMKDPLLNSIYYETLRLRV
ASTVGRTSLDDQLCLAGGWKVKAGVPVMFTGWLAGLDVSCWNTGQDLSSGKPQHPLEAFWAERFLDCPGSSSISGPAKKK
RVQPARESPQRPTTHMGAEDARSRASVAGLRGHFFPFGGGAFRCPGETLAKQVIFASVAMVLQSYDLRLIDPEEARKIER
GHRELPFGLHSFDRPVPVEICKLSET*
>CYP5133B1 Glomerella graminicola
ET530821.1, ET595126.1, ET586230.1, ET611727.1
ET452524.1 GSS sequences
43% to CYP5133A1
526-ub
>CYP5134A1 Gibberella moniliformis 7600 chromosome 11
cont3.130
53kb from a PKS
AAIM02000130 revised
Also = Fusarium verticillioides FVEG_10550
Not highly similar to any known P450, 36% to
526E1, new family
MFSPTPQTLSIIIVVFILTTL
83381
LIRRALLPKPIPGIVYREANAKKVLGNAWELLQWKKKHGEMFGYLANLAVELNEPVFQI 83205
83204
FVHPLGKPWVIVADNREAFDILSRRTPKEFDRSRFLRSLFMPLVPEFHFHMPTGDRWK 83031
83030 AHRKLVADTMSPAFLGGVAGPQMWKSTMKLIDLWRVKERLAKGRPFSVSTDIRKAAFEII
82851
82850
WAATFGFDSGSTSAQTELLETLPEFTNLPDMDHEVHFPVAPDPPVFKAGLALNDAMNIG 82674
82673
VQSLVPGLHLWLAYNLMPSLRAARSLKEAVIQDMIKQAINKFSNQTDLNWEDQGNLKR 82500
82499
HMKSAVDIVIAREIDSARKEGRTPELMSRTVQDELFSFMLAGNEIFTLTAWTLKFLTTH 82323
82322
QNVQKKVRDELREQCSAAVERGDAPTVSEIMSARLPYFEAMIEESTRCGSVTQTNIRTTM 82143
82142
QEVNILGHMVPKHTEILMLNNGPGSFMPSLSVDEEKRSESSKGTAGKIGQWNVKGMRDFD 81963
81962 PERWLVKDEEGRLTFNPNAGPRHSFGAGPRACF (1) 81864
81813 GRKWAALEVKIMMALIVWHFNLEPTPKPLSSFKPFPGVAHRPEMIYLRLSNV*
>CYP5134A1 Fusarium oxysporum (temp 5134A2)
95% to CYP5134A1 Gibberella moniliformis
FOXG_11969
MFSPSPQTLGIVVAVFVLATLLIRRALLPKPIPGIVYREANAKKILGNAWELLQWKKKHGEMFGYLANLAVELNEPVFQI
FVHPLGKPWVIVADNREAFDILSRRTPKEFDRSRFLRSLFMPLVPEFHFHMPTGDRWKAHRKLVADTMSPAFLGGVAGPQ
MWKSTMKLIDLWRVKERLAKGRPFSVSTDIRKAAFEIIWAATFGFDSGSTNAQTELLETLPEFTNLGDMDHEVEFPVAPD
PPVFKAGLALNDAMNIGVQSLVPGLHLWLAYNLMPSLRAARSLKEAVIQDEIKKAINKFSNQTDLNWEDQGNLKRHMKSA
VDIVIAREIDSARKEGRTPELLSRTVQDELFSFMLAGNEIFTLTAWTLKFLTTHQNVQKKVREELREQCGAAVERGDAPT
VSEIMSARLPYFEAMIEESTRCGSVTQTNIRTTMQDVNILGHMVPKHTEILMLNNGPGSFMPPLTVDEEKRSESSKGTAG
KIGQWDVKGMRDFDPERWLVKDEEGRLTFNPSAGPRHSFGAGPRACF
(1)
GRKWAALEVKIMMALIVWHFNLEQTPKPLSSFKPFPGVAHRPEMIYLRLSNV*
>CYP5134B1P Neosartorya fischeri
43% to CYP5134A1 Fusarium oxysporum, 40% to
CYP526G1
one stop codon and a small deletion, probable
pseudogene
NFIA_045710, NFIA_045720 join
Note: this seq does not have an ortholog in A.
fumigatus
MLHHTFCTYLSAHLHPSPNHNVPVPSHFSFDSMAIQISPSILGVAACVLFAVAACVVYRAL
LPKPIPGIPYNKASANRILGDAPD (0)
LLKWRAETKEICSYIRKLA
VELDSPVIQMFMRPFGKPWVIVTDFCEAQDIQINRQHEFDRSTYIGEVFGPLLPGNHVW
(0)
MPSNDEFRAHRHLIRDTMSPSFLHDVVGPAIHSSTQDLLALWRERARLAQGRPFEADQDIIRNLVD
VILVATFGFEVGAIASQTKLISGINKIDLPWNVDVPAIFPTAKDPQAFTSVRTLVDSL
QIALRSPVPRQRLTFALKFYPSLVSARRWNKRMMGDRLQAAWKKFSDNAD*DEQVKSAVDLLVQREAQ
MAKRQNRDVMYDTRVIRDELFGFFSAGHETTSTTICWAVKYLTDHQEVQQTLRSSLKLVHKRAAESGELPTAQEIVKADI
PYLDAFIEENHRLGNSIPTVIRITTRDTVVLGHRIPKGTDVFMLTNGPSFQTPAFAVNESARSKTSQESKDKYGVWDASD
IERFRPERWLVKDHEGNLRFNPRAGPVLPYGLGPRGCFGIKLAVLELKVIITLIVWSFELQKTPPSLSGFGGDDMNTYRA
QQVYLRLVEAK
>CYP5135A1 Phomopsis amygdali
AB272062
PaFS gene for fusicoccadiene synthase
And related P450
For fusicoccin synthesis
Only about 34% to CYP65 members, 42% to 65AB1
Aspergillus oryzae
New family
9629 MSPQAVNSLEKTCNLLNLQVLGLTLLFSK
9542 LFYNAYLHPLRKFPGPLLARLSRLYYSYYRSTGQLEWKTLELHKKYGSVVRIAPN
9378
9324
LVSFNAGTAWDDIYGHTTKRRSGRRLQKEAFFYLGAVAPNGEKNLGASSDEDHSRIRGV 9148
9147
LSSAFSEKAVFAQEDLLMRHIGFMVERIRSLNGIPTDAVRWLHHCTFDITTDLSLGA 8977
8976
SAKTLACDEWSPLAHLMFEGIKEGITAVEILRFAPFKYQAFSLLIKAFGKARLEAFQAAI 8797
8796
NQAHIRMAQATTDKEDKKPDFMSHIIKANKTSKALTPSEITANVALLLDVGSETTASLL 8620
8619
AGCLFYLTKTPHILEKLTSMIRKDFQTPQEINSKNLAQNSYLTAVLNEALRIYPPVAGA 8443
8442 TPRVTPPEGSQ (1)
IDGRYVPGNISVAVNQVAMNRSPKNFTNPDQF 8263
8262 VPGRWLGDGCFPDDQLQLCQPFSHGPRACLGRN (2)
8164
8108
LAWAEMRLIMGHLLWNFDVELSSESENWNSQKTWFIWDKPDLMIRFKSREGQ* 7950
>CYP5135B1 Mycosphaerella fijiensis
50% to CYP5135A1 Phomopsis
amygdali
e_gw1.2.701.1
MASIPWPALLKLVLALFIWTGTRVIYNIYFHPLRSFPGPVLARATRLYSVYIRAAGLSDWKALQWHNQYGGIVRVAPDEL
SFSTGSAWEDIYGTKLSKSQRLQKDPHFYMGATAPNGEKNLGAANDEDHSRIRSVIAHGFSDRALHTQEGLIRAHVDRLV
QHLGDLHEKPTDIVRWIHHHAYDVIAHLCFGQDLDALSSKGWFPPAKAVFEGIREGVTLIEVLRFVPFKATVLGMLVWAF
GKARRENFDASVSRAMLRLRQEETDNVDFISYILRAKESAKELTPSELTANVALLIDAGSETTATMLCGCLFYLSMDRTT
LEALTSTLRNEFKTYDEITLRSLAKMKPLTNVLQESLRVYPPLPASLPRMIPGTGATINGILVPPKTRVGVHQLAAYHSA
KNFAQPDKFLPERWDGTDERFAHDQRYVLQPFSLGSRGCLGKNLAWAEMRLTLACLLWSFDLILEPGQEKWHKKQLTWFI
WDKKPLHMRFVPRRK*
>CYP5136A1 PFF_311a
Phanerochaete chrysosporium
MSSLLVLVAISLALSQLIRFYRWLFHHSISYLRGPVADSFILGNVREFTYQESVGDLDFRYMNEYGTAWRMKSILGSDVLMICDPKALQHVLHKSGYHYPKNTEARIGSFNVTGRSILWAPNGDIHSRHRKIMNPAFTAQQLRSFLPLFRRGSNKMCQLWKDEVLAQAPTGMTIAVNQWLARTTLDVIGEAAFDFSFGALDDADNEVSKAYHNMLFADSLLYPSAWSTIFRGLWRFIPDQLLSYVRYLPTREYTRFRYTLNIINKVSKSLIDQKSEDLLSGDKSSKDVMSVLVRANSSENPRSQLSEEEMVSQMATLTLAGHETTANTITWLLYELAKHPEYQQKMREEIAVKRAEINARGDADFTMDDLESMQYLHAALKETLRYHPIVYHLAREASKDDVIPLAYPVTTIKGETVSEIPIAAGQIIMPNIAAYNRLPQVWGDDAHEWNPLRFIDDSPEVQVRLGMFGNLMSFFAGVRGCIGWRFSLIEMQAIVADLVENFQFSIPPEKPEIIRVPAGIMGPMVKGKMHEGLQMPLHVTPL
>CYP5136A2 pc.142.11.1 Phanerochaete chrysosporium
MAAAALLIICWLVVNLRRLLTHNSIRHLRGPPSASTLFGNVTDTLYQASVGDVEFRWLKEYGGAWRLRGLLGANILALADPKALQHVLQKSGYNYPKTRQLSVTLFNLTGRSILWAPTGEIHARHRKVMNPAFSVPQLRSFIPLFRQSAKKLTQIWKDQV
NAGHPDGVTLPVDRWLARATLDIIGEAAFDFDFGALDNTENEVSKAYHRMFADSQLYPSVWNLLFQATWSLLPEPLLYYIRYLPTREYKTYRSTLSVMDKIAAQLIEERTREFGAGDPDKSRKDVMSVLVRANMSENPSTRLSDEEMRSQMFAMTLAGHE
TTANTVTWMLWELAKHPDIQEQLRQEIAEKRMEVTANGSYEFALDDLESMPLLQAVIKETLRYHPISSFLWRVAAKDDVIPLEKPIVTTTGETITEIPVAAGQVIMPSLCSYNRLAHVWGEDAHDWNPMRFLQGDTEKQTKVGMLSNLITFSAGVRSCIGWRFSVLEMQAIVVELVENFRFSLPDNKPEIIRAPTMTMGPMVKGKLHEGFQMPLRVVPV
>CYP5136A3 pc.16.161.1 Phanerochaete chrysosporium
MAVIDYTLHASSPLVLLACTVCVAVLAFRWYSSSTHGSIAHIRGPPVKNPILGNIRDFSYQENVGDLDFAYMKEYGTAWRLKSSLGKSVLMVADPKALQHIFHKSGYLYPKTTPSTVRSFLVTGKSILWAPDGNTHSRHRKIMNPAFSAPQLRSFLTLFRKSSSKLCQLWRDEISPEGSTVLVNKWLARTTLDVIGEAAFDFDFGAMQDNQNELSVAYDNMFTDATLHTSPWNAIFEALWDYIPDGILKQVQHIPTREYARFKQTLGVFAKYSKRLIAQKSADLVSDTHSKDVMSVLVRANAAEDAGRKLNDEEMVSQMSALTLAGHETTANTISWLLYELAKHPDFQEKMHAEIVAKRAEIVARGDEDFTMEDLESLEYLQAAIKETLRYHPIAFHLNRMASQDDVLPLAYPVMTTAGEKVTEIPVRKGQAIMPNLAAYNRIPEIWGADAHEWNPMRYIENRTDAQVRVGMYANLMTFSAGVRGCIGWRFSLIEMQAIISDLVENFRFGLPKDRPEVLRVPAAVMAPMIKGRMEEGAKLPLHVTVY
>CYP5136A4 pc.16.153.1
Phanerochaete chrysosporium
SGACVLCLAWLAYRWYRWTTRLNISYIRGPPVKSWILGGNVRDFAFQENVGDLDFKYVQEYGLVWRMQQPLGAQVLMVADPKGDIHARHRKAMNPAFNNAQLRSYYPCFRRTSSKVCQLWKDQILSQGPNGATIRVDRWMARAALDIIGEAAFDFDFGALDDSANELSAAYHNMLSADSTLRPSAAQAVFQGLWTHAPLRVLERVRHLPLRDIARFQHAMRVFNTYAARLMARGAAGAAHGRDVMSVLGTAHANASADPRTRLSAEEVRAQMCALTFAGHETTANTTTWLLWELARHPPAHQDSVRADTVRRRAHVAARGDADFGVEDLDALPCLEAAIRETLRCHCIVFHLNRVASQDDVIPLSRPLTTATGKTVTEIPVAAGQVVMPNIAVYNRTRTKWDPTRFLDGRVDNPEVRLGVYGNLRTFAGGVRGCIGRHRMIEMQAIVADLIGHFRFSIPDDKPEIVRAPSMLMAPMIKGKEHEGSQMPLHV
>CYP5136A5 pc.14.209.1 Phanerochaete chrysosporium
MFHGYLSATFQAQRRPGNIKDFTYQQNVGDLDFQWVKQFGRVWRMQSPFGTDILALADPKAMQHCFHKADDQYNKRVESTVGSRMMMGKGLVWASGTTHERQRKIMSPAFTTAQIRSFLPFFRAGAAKKWRDELFNHSTDGAAVPVNKWFSRATLDILGETAFDFNFGAVDDKDNEVTLAFHTMLFANSCLRPPKWDLLFKRIWYFLPNPLLELVQYVPTKEQNRFRRCRLVVEKVSQQLIQEKREALLAEAKSSRDIFSVLVRANVSENPNSRLSDEELIAQMGTLVLAGHVTTATTLSWMLYELARRQDYQDKMREEIVAARARLQERGQQDFSMEDLENMHYVSSCLKETLRFHPPVYHLFRQANTDDVIPLEQPVRTTSGKYVTEIPVAAGQQVLFSVCAYQRLPEVWGEDAGIWNPMRFIDGNVDKQSKLGLYSNLMTFSAGSRGCLGWRFTIVETLAIIVELLEHFKFEPTEDTAKVIRVPTGIMSAFTAGKEREGPQMLLKVVPIL
>CYP5137A1 pc.5.122.1 (SEQ ON OPP STRAND FROM THIS MODEL #) Phanerochaete chrysosporium
MNNLTAALILVALALWFACRRFTRTTLRDIPGPKPVSFWLGNLEQYFLGQAGEGDFHLQERYGRIARLHGSIGGEYLWISDPNALRYIFQTSGYRYAKQPERRALSRLHSGHGLVWADGEVHKRQRKVMLPAFGAPESKALLPHFARAAEAVSVKWKDILTTAPSLSKELNVSTWLSRATMDAIGEAAFDYHFGALENTDTDIVRAYNNLMPIVFGAPTADAIFKRDALRIFRSSRIVEWIYDRQRNPAVEKARECEELTLKIARELVENKAEALEQGKGSKDIFSLLVKANMTEDAKSRLSEEEMYAEMRTILFAGHETTSTTISWVLLELARHLPVQERLREEILAHKRGGELSATDLDGMPFLQAVVREALRLHPVLNQTFRQAEQNDVLPLAHPLTDRTGTVLTALPISKGTRVILSIAAYNRDTELWGSDAHAFDPDRWLDGRVKKVQTLGMYGNLLTFAAGVRGCIGWRFAVYEIQTFLVELLANFEFRPTEDLKRLRREPCGVMVPTLEGDRGTVQLPLRVSLLDHKI
>CYP5137A2 PFF_88 NOT IN TREE Phanerochaete chrysosporium
MHDIFPLAVLLGALLWIVRRILSRSSIRDICGPEPESFWLGNLKQFFMRQAGEGDFELQERYGRIARLHGSIGGEYLWVADPKALQHIYQASGYNYAKQPERRALSRLHSGHGLVWAEGEVHRRQRKIMLPAFGAPESKALLPHFIHIAESLSMRWKDILLASRDFAKELDVTEWLSRATMDAIGEAAFDCQFGALDNGGSEVLRAYNDLLPMVLGVPTTDGIWKRDAMRIFNSSAIVEWIHDRQTNDVLQRARECEQMVMKVAKELVSSKAEALVQGKGSRAYFSLLVKANAAEDAASRLSDEEMYAEMRTSSLAGHETTAMALSWALLELAQHPEVQSRLREEVRGCKRGEELSAAVLDSMPYLQAVLREVLRVHPPAIHNFRQAVRDDVLPLAHPITTKSGSVLTELPIQKGTRLILSIAAYNRDPDLWGSDPHMFDPDRWLDGRVKKGQVVGMYGNLLSFSAGVRGCIGWRFAIYEMQAFLVELVSNFEFGPTEDLKRLRREPCGVVAPMLEGEQGVQLPLRVSLANYDV
>CYP5138A1 pc.65.27.1 Phanerochaete chrysosporium
MPLLSAVPAAALPLLGAALYVLWTFLALLVRQARSPLRHLRGPPSPSFLVGNLREMHDQENTALFARWEHRYGSTFVYHGFLGGARLLTTDPVAVAHILAHGYDFPKPEFIRDALASMAAGHEGLLVVEGEDHRRQVRASPAFATPHIKSLSPIIWSKATQLRDVWIDLASSPSLTPAATPPGTKVDVLAWLARATLDVIGEAGFGYAFNSVRAAACPGDAAEDELARAFAVIFSTARKFRLITVLQVWFPFLRRFVSIPPRCFLALPLKSSLSSDPSQQLSTNAMLCQIATFLAAGHETSASALSWALYALARAPACQHTLRRELRALTLPADPSAADLQAVLALPYLDAVVRETLRVHAPVTSTMRVAAHDAAVPVGTPFRDAHGAQHAAIRLRAGDIVTLPLQAMNKWGADAACFRPERWLAHGDAPREPRGLWGGVMTFGTGVVANGNRSCIGYRFAVNDVVTRPCVKSEPHLGNQMPLRLRRVAVEETVGDSSGDGAPRTVS
>CYP5139A1 gx.38.22.1 Phanerochaete chrysosporium
MGYPLAVYAVGALVALIVYSVGPTVWHVLTSPLRHLPGPPNDSLLWGNMAAIQNEEISVPQARWVKQYGHTISYRGVFGMWRLWTVDTRALNHILTHHLIYQRPLPSRYQLSRLVGPGVLVTEEERHKHQRRVMNPAFGPAQVRELTEIFTEKANEMRDVWYNEITKAGGASAQVDALSWLSRATLDIIGRAGFGYDFEALTGASNELNQAFSTLFARPIARHRFFARIGMQLIEQRKAAILAEKGKDVERKDLTGRDLLTLLIRANMATDIPEDQRLSDEEVLAQVPTFIVAGHETTSTATTWALFSLAQMPEIQRKLRNEMLTIDTDTPSMDQLNSLPYLDAVIRETLRFHSPVPVTTREAMADDVIPLGTPTVDRYGRTIDHINIKKGDLVFVPILAINRSKEIWGEDVDDRPERFENVPEAASTVPGVWGNVLSFLGGPRACIGYRFSLVDIVTRPVMTGPDGKTRGALPLIIRPYRP
>CYP5139B1 Cryptococcus neoformans var.
neoformans B-3501A chromosome 6
AAEY01000032
CNBF3400
EAL20013.1
42% to CYP5139A1 Phanerochaete chrysosporium
yellow region is too long
MTMELLKVLHHGASQLFPNCIRSSPVACIVLYSFGGIAILLFTV
YLWLWPFQYAKLYFRNLPGPPSDSWFWGVVPTLIKSPPSVPHSMWTDEYGPTVRYRVA
LGAQRFLTIDPTALNYILSHADLFPKPSRVRKALSDLLGNELLTAEGHTHKKQRKALN
PSFSPAAVRGMIPVFYDKAYELKAKLLGIIEGDETEQASPTPCKEEDEVEGGKKIDVM
KYLGKTTLDVIGIVGFSYDFKALSEPRNELSEAYSKMF
QAGMDANFWDFLRGAIPLVNKLP
NKRATEIAARKAVTLRISKKIVEDKKREVMSAHSEGLEKREDIGDDLLSILIKAN
MASDVKPEQKLSDEEVLDQITTFMLAGNETSSTALTWILYSLTQHPECQKRLREEVLA
VPDDRPSLETLNNLPYMDAVIREALRLHAPAPGTMREAKEDTVIPLSMPVIGRDGKQI
DSVKINKGTMVFIPIITVNTSPAIWGPDARVFNPDRHFKTSSDSFGGANMHVPGVWGN
MLSFLGGARNCIGYKLALAEISTILFVLIRSFEFQELKSKPEVEKKASVVMRPRIKGE
ESAGLQMPLMVKPLLM
>CYP5139B2 Cryptococcus neoformans serotype A
CNAG_05842.1 94% to CYP5139B1
MELLKALHHETLQLFPDCIRSSSVACIVLYSLSGIAILLSTVYLWLWPFQYAKLHFRNLPGPPSDSWFWGVIPTLIKSPP
SVPHSMWTDEHGPTIRYRVALGAQRFLTIDPTALNYILSHADLFPKPSRVRKALSDLLGNGLLTAEGYTHKKQRKALNPS
FSPAAIRGMVPVFYDKAYELKAKLLSIIEGDETEQASPTPCKEEDEVEGGKKIDVMKYLGKTTLDVIGIVGFSYDFKALS
EPHNELSQAYSKMFQAGMDANFWDFLRGAIPLVNKLPNKRATEIAARKAVTLRIGKKIVEDKKREVMSAHSEGLEKREDI
GDDLLSILIKANMASDVKPEQKLSDKEVLDQITTFMLAGNETSSTALTWILYSLTQHPECQKRLREEVLAVPDDRPSLET
LNNLSYMDAVIREALRLHAPAPGTMREAKEDTIIPLSMPVTGRDGKQIDSVKINKGIMVFIPIMTVNTSPAIWGPDARVF
NPDRHLKASSNSFGGANMHVPGVWGNMLSFLGGARNCIGYKLALAEISTILFVLIRSFEFQELNSKPVVEKKASVVMRPR
IKGEESAGLQMPLMVKPLLM
>CYP5139C1 Sporobolomyces roseus
estExt_fgenesh1_pg.C_10483 gene model revised
39% to CYP5139B1 Cryptococcus neoformans
MERLVDLVVYPLNHPFYTLL (2)
FAIILVVPATALWLAYSIFISPLRSSL
RDVPGPARKSLLWGNMEQIFAEQPGRSHIEWNEEFGGAARYHGLLGNQRLVLFDHAALNHVLLSNCYE
FPKPEEVRGDLAMILGKGVLFAEELIQSSAGDDHRRQRRILQPAFSPAHIRALGPVFFEHAYKLRDIWTNLVKTGADDEK
AFADSESFETYRKNKAGREEVTLDIMPWLSRLTLDIIGVAGFGYHFDSLNRSTNKLANAFAGMFSPSAVAK
KPKPSAFLLQRI
IGFFIRALPILNIAKWIPNDRIQRVRQGFATLESESRNIIESKQGEVEKDGLESVRGSKDLIALLLKSASTDAKAKM
SAEELRGQLTTFLLAGHETTSTSLTWTLWTLSRYPDMQSKLRAEVRAARKKAKDNGNDEIESDELAALPYLDAVTREILR
LESPVSATIRHAAQDDLIPLSRPIRSRSDPNSTISHIPVKKGQILFIPITAVNHSKEIFGPDASEFRPERWIGTEGDKIQ
GKVGVWSSMLTFLAGPRSCIGYKFALLELKAILATLIDDFEFSLRDPPFEIERRSAIVMRPLVIGEEPLGNRMPLRITLA
KRDEQE
>CYP5140A1 pc.96.21.1 Phanerochaete chrysosporium
MNASSIDFFPRNLATSPVFSAKPFLLALSLISTYLVSVAFYRLFFSPLASIPGPWYAAVSDLWITTHVLRMQQCRVVQDLFDTYGPIVRIGPNKVAFCDAGTMRSVYCVHKFDKSAYYKSLLTNNNDHAMTTLPHAEHAIRKKTYAPHYTPANLALFQPELNDLALKLTDILSIRSSSVDVLDLFRHLMVDVIACTVFGSRSGSLDNWNKGVRDPLSIAVYDFPKRGIMVRLCLSSPVTASDNHIRSGAQCLLGPGSFIAGVDTSSTSLSYMFWELSRRRDVMQRLQAEIDEIMPDPRVIPDATVLNRSEYLNAFVKECEYACHPCPAEILRDPIALHFDMMGYALPPGTIVATQAWSMHRDEDVFPSAETFLPERWLVDPHADREVEEERLARMHLHLVPFGVGTRQCGGQNLAHLMIRIVVAVVVRNCEVRADVRETNERSMSMRDAFVSPLLWLLLGSERS
>CYP5141A1 pc.181.9.1 Phanerochaete chrysosporium
MISDTFALAISSGLSLFLCLKAFIDYRAGLRSINHSYLPGFRALISSFGILGLFFKEPKRGLWGGRRRFWLRKHLDFEEAGVDIISHIAFLPSVSTYLLLADAAAIKEVTGHRARFPKPTYKTLRIFGGNVLASEGEEWKRHRKVVGPAFSEHNNRLVWNETVKIVNDLFANVWGSQSEVYVDNVVQSVTLPMALYVISIAGFGKRALWQADGNLPPGHKLSFQDALHILGTDLWIKAATPTLLMNWAPTTRIANVKLAFDEVKQYMLELIQERRNSEKRDERYDLFSSLLDANDLNEDGNGNVTLTNDELLGNIFIFMLAGHETTAHTLAFTFGLLALHPDYQETVYQQIKSIVPDNRPPMYEEMNSLTECMAYETLRLFPPTATIPKIAAEDTYLVTIDRAGNRVVVPVPCGTALHLNVIALHHNPRYWDNPSAFKPERFRGDWPRDAFIPFSTGSRSCIGRRFFETESIAILTMILSRYKIELRNDPRFADETYEERWQRVLRVKDGLTPA
>CYP5141A2 gx.37.18.1 Phanerochaete chrysosporium
MFSNTFALAITSGLLLSCLKAYMDYRAALRSINYHPGSCALIPSFGMLGLLFKEPRRGLWGGWRRFWRRKYLDFQEAGVDIISHIAFVPSVTTYLVLADAAAIKEVTGHRARFPKPSYEFFRIFGGNIIASEGDEWKRHRKIAAPAFSEHNNRLVWNETVKIVCGFFENVWGSQAEVYVDDVVQSLTLPMALHVISIAGFGKQTVWRADGTLPPKHKLSFQDALHVVSTDLWIKFVMPTMLLDLAPTKRIAKVKLAFEEVEQYMLELIQERRDAEKRDERHDLFSNLLDANDSDENGDGSVKLTDEELLGNIFIFMLAGHETTAHTLAFTFGLLALHSDYQEKVHQQIKSIMPDNRLPTYEEMHLFTECTAVFYETLRLFPPVTTIPKISAEDTSLVTTDRAGNRVVVPVPCGTSLHLSVVALHYNPRYWDDPYAFKPERFHGDWPREAFIPFSAGARSCLGRRFFETEGIAILTMILSRYKIELKDDPRYAHETYEERWQRVLDVKDGLTTT
>CYP5141A3 PFF_77b
Phanerochaete chrysosporium
MNSVLVILLSTILLLCLKTYVDLRTALRAVNYHPGFKSFISCFGVFGFAFKEPRRGLIGGSLRFWHRKHLDFDEAGVDVIHHVSFFPRVSTCLILADPAVIKEVTSHRALFPKPLYHELRLWGGNIIASEGDEWKRHRKVGAPAFSEPNNRLVWNETVKIMVDLFDNVWGSQDTIIVDHVVDAFTLPVALFVISVAGFGKNASWQSDLLPPSGHKLSFKDAIHVVSVDMFIQVVTPTFLWKLAPTKRIADVKLGFEELEKYMLEMVEERRNAPKKEERYDLFSSLLDASDSDADGGARLTDRELLGNIFIFLLAGHETTAHSLAFTFGLLAMHQDYQEKLYQHVKSVIPDGRLPTYEEMNKLTECMAVFYETLRLFPPVVGVPKVVAENTTLVATDFTGKRRAIPVAAGSDIHISILALHYNPRCWDEPHAFKPERFHGNWPRDAFLPFMAGPRACLGRRFFETEGIAILTMLVSRYKIELKDEPAFAHETYEERWDRLFTVKQGITLA
>CYP5141A4 pc.181.12.1
Phanerochaete chrysosporium
MGTLAWVVLSFCLFYCVQKYLEFRAVVRSIHDHPGFRTLLPPYGIFGFLFKRPIPGITRGGMSQWRGKYRDFEAFGMDIISATSVIPTARNAFLVADPAAIKEITSSRTRFPKPVAQYRVLTFFGANIVTAEGDEWKRFRKITAPAFSERNNRLVWDETVKIMLDLFENEWAGKDTVVVDHAVEVTLPWIALFVIGVAGFGRKMTWQEDSKLPPGHQLSFKEALHYVSTAVFVKLATPAWLLTWAPTERMRRTNLAFKELEQYMLEMIQTRRNSEKKEERYDLFSNLLDASEDGSDGHARLADEELLGNIFIFLLAGHETTAHTLAFTFGLLALYPEQQDKLYKHIKHVIPDGRIPAYEEMNLLHESIAVFYETLRLFPPVTGIPKVAAEDTTLVTTDHSGNKVVVPVTKGTGISLHVPGLHYNPRYWDDPYEFKPERFHGDWPRDAFLPFSSGARSCLGRRFFETEGIAILTMLVSRYKIEVKEEPEFAGETFEQRKERILAARGGLTLTYVCSPPHLRNLLNLPLR
>CYP5141B1 pc.37.84.1
Phanerochaete chrysosporium
MQQHLLFAAGLICLFLVKRCIEYRRAIRAIHNYPGVRAVLSNSSGLGYLCKRSIPGLAVGGARLWVKRYSDFCRYGADIVSCVAVLPRTEILLFVADPAAIKEISSDKTRFSKPTELYELVNIFGRNIVTTEGDEWKRHRKIVAPAFSERNCELVWEETLHVMIGLFNDVWGSDSIITLDNAFDITMPISLFVVAASAFGRRIPWTEGGLAPPGHHMSFKEALHIVSTGTVIKAVLPKWLLNLGPSQYIREVRDAFREMEAYMREMVTENMLDDTKSRRDLFSSLVHAGQDSPGQEALLTDAELLGNVFMFLLAGHETAASTLCFALGLLALHKDEQDKLYDHIRFTLGEKDVPAYSDLTSLSYCSAVLYETLRLFPPVIGIPKKATEDTVLSTVDRDGNHIAVPVPVGSSVAIHVPGVHYNPRYWKDPAAFRPSRFFGNWPRDAFLPFGAGSRACIGRRFFETEAITALTMLVVRYEISVTDEPQFRDETAEQRRERVLSATQELTLT
>CYP5141C1 pc.81.19.1 Phanerochaete chrysosporium
MASRLLVLLAALVLFALRAFARFRRAVHAVSYVSSALRSVNHPGYRTLLNTLGPIENFFPRIPGVAPGAFHMWKRKHRDFEEHGWDVITY
VAAFIGSSTNFYVADADVIK ()
EITTHRSRFPKPIEQYKVLTFFGGNIVASEGEHWKRYRKIAAPAFSE ()
RNNKLVWDETRLIMQDLFTNVWGERAEIYVDHAVDITLP ()
IALFVIGVAGFGRRIPWQDEDVVPAGHTMTFK ()
TALHTVSENVFTRLLIPDWLLRAAPTARLARIRDAFAELEQYMREMIRARRERPAREERHDLFSSLLDASKDADVRLQDSELIGNMFIFMLAGHETTAHTLCYMLAMLAMHPEVQDKMYESIRGVTQNGRLPEYEDMRSLSYCEAVLYETLRMFPPVNSIPKSVAEDTAITITNADGERTTVPMPKGSSISIHTPGLHYNPRYWPDPHTFRPERFLAADWPRDAFLPFSAGPRACLGRRRFSETESVAAAAMLVLRYRIAVADEPRFAGEGARARFERVTASRPGVTMTCVFCAPLWVVVGTDELCCRPTRVPLVFRRR
>CYP5141C2P pseudogene
FRAGMENT pc.167.26.1 91% TO 5141C1
genewise.20.89.1 [whiterot1:25284] Phanerochaete
chrysosporium
VAAFIGSNTNFYVADADIIK (0)
EITTHRSRLPKPIEQYKVLTFFGGNIVASVGEHWKRYRKIAAPTFSE (0)
RNNKLVWDETRLTMQDLFTNVWGRHAKIHVDHAVDITLP (0)
VAGFGRRIPWQDEDVVPAGHTMTFK ()
TALHTVSENVFTRLLILD
>CYP5141C3P pseudogene FRAGMENT pc.67.69.1 84% TO 5141C1
Phanerochaete chrysosporium
VASFIGSNANFYVADADVIM (0)
GNTTHGSRFPKSIEQYKILTFFGGNIVASEGEHWKRSRKIAAPAFSE
(0)
RNNKLVWDETRLILQDLFTHVWGKRAEIHVDYAVDITLL (0)
IALFVVGVTCFGRRIPWQNEDVVPAGHTMT*LK (0)
TVLHTVSENVFMRLLIPD
>CYP5141D1 pc.81.21.1 Phanerochaete chrysosporium
MLLILWALLAAVVYHAAARLVRLRRLLVKIRFHPGQRAATSIYGAATFLFPWRIPNLTPGANLLFDEKHALLARHGLDVVTSVSTHPMRAVFVVADPAVLRDMAAARSRYPKPVELYGSLSLYGPNIVASENDAWKRYRRICSPSFSERNNKLVWEETVRVVTELFDTWEGRQEIDMEDALTMTLSITLFVISSAGFGKPITWKGGDERPEGYAMSFKDVIYHMSTGVFIKIATPQWLLNLGLTEKMRNTNVAFKELGMYMSDMIRERRESQQREDRGDLFNGLLDAGEEDEKLKLTDEELMGNIFIFLIAGHETTGHTLCYALALLALYPDEQEKLYQHIRTLCPAGELPVYDDLRNYTYALAVLYETLRMFPSVVGIPKVASEDTCVQTMNDAGQLVEVFIPEGSDIVFDTPGLHYNPKYWTDPYTFSPSRFMAPDWPRDAFLPFSGGPRACLGRRFARFAEIESIAVLVLFVSQYTIHLKEDPKYAGETEQQRRERVLKSVPGLTLT
>CYP5142A1 ug.79.41.1 Phanerochaete chrysosporium
MDDVNLFIRARTLLDSVLVLILTSIGYAVANAVYNVYFHPLSKFPGPRMAAASRWWKTYVEVYRDESIVDRLFHLHEKYGNVVRIAPDELHFSDPAVYNAIYSPKSRWNKDPLMYAPFGFGSHRSMFSTVEYQPAKKRRDLAAPHFSRKSVLNLQGVIQAGVSNLCDAMAQRAAEGKPTDIYSAFRCLNFDNVTSYCFGWSLHMVRSPDFSAEPVQNMQDMHSSYQVWKHFLWLRTPMRLLLSVLGKRPMPYFRVIMEQVDGYLERPEELDNAPHSLIFHSLMDPAQSTKLDKQSVVEEANLLIIAGTDTISNASALGTLFLLSDGGYMRDKLQAELKAIWPRLDDKPSLEVLESSAPYLKAACKESLRLSHGVMSPLLRVVPSQGATLGGHFVSGGTKVGICNAFVHLNPALFPDPHVFRPERWPEPGAESLDTWLVAFSKGPRSCIGINLGWCELYMNLANLFRRFDLKLDHRVQVLFLGGS
>CYP5142A2 pc.79.57.1 Phanerochaete chrysosporium
MNVWARVSEGWTALEVILVALLTSIGYVVTTALYNIYFHPLSKFPGPKLAASSWLWKAYVEVIKGESILDRLSKLHEEYGPVVRIAPDELHFNDPAVYNEIYTARSRWNKDDVMYAPFGKDTSIFTTREFREAKKRRDLSAPHFSRKTVLSLQGLIQEGIDEFCEVITKRDADSKTTDIFRAFRCLDFDNVSSFCFGWSEHAIQAPDFNSAAVEELQHSNKDFQFWKHFLRLPLPVLLLASRIKNQIATYIDKPEELDKTPHPTVFHVLMDSSHGTRLSATAMAEEASLFLIAGTDTTSNASALGTIFALSDNGYMRNKLKEELKSVWPRLEDKPSLEVLESLPYLKAVCKESLRLSHGAMSPLMRVVPQQGAVLGGHFVPGGTKVGMAHTFVHFNPTLFPEPHTFRPERWLEPGAEALDTWNVAFSKGPRSCLGIKSLAWCELYMNIAHIFRRPVRPYDLWHRDCFLPYLDGVDLLVYATPSTD
>CYP5142A3 pc.24.27.1
Phanerochaete chrysosporium
MDVVRQALEGRTTKEYAGLALLAFAAYVVANIIYNLYFHPLAKFPGPRAAAASRWWKAYVEVYKGESIVDRLFELHAEYGDVVRITPDELHFSDPKVYNEIYNTRSRWDKDGEMYAPFGGNSTMFTALRYHDAKKRRDLTASLFSRKSVLSLQGSIQEGL
DELCDIISARSAAGKTTDLFRAFRCLNLDNVTSFCFGWSLHTVRAPDFRAPPLEEVQNSHGGYQFWKHLMLFRAVLLPKLKEQVDALVARPDELEAAPHPIIFHSLIDPAHGAKLSAQELMEEANMFIVAGIDTTSNATGAGVIGVLSNPSTYDKLKTELRTAWPRLDEKPTVEVFESLPYLKAVCKEALRLSHGITSPMLRIVPPQGATLAERFVPGGTQVGVSHLFVHLNPTLFPDPHAFRPERWLEPGAESLDTWLVAFSKGPRSCLGINLGWCELYLNIANLFRRFDLKLEGRAKAFLDGPRARASGDWKDCFLPCFEGPDMLIHTTPVAD
>CYP5142B1 ug.20.42.1
Phanerochaete
chrysosporium
MLNLSLDSSSVLSLVWTASPWLLLSWILYTVLMAVYNLHFHPLAKFPGPKMAAASEWWLAYVEVIKQESLSKKLWELHEQYGANATQLHFSKPAAYNEIYNVKNRWDRDMKLYHIFADEVSTLTIPDYARAKKRRDLTTFLFLARILLRQLDTVCENIDKHIKEGKPVSIFKAFRCAAADVICTMCFARSMNATSEPGFNAQVVTAIHAAFPVIMVFKHFPLLQTLSRMVPPLLLSSLRPELNGLMKMRKMLTDQVKEVKAHPEILKESQQVTIYHELLKDPKNIPSDTSLRDEAVLYVTAGMDTSSDTLTLATINVLSRPDVHARLMHELVEAWPHLEDAPPRYEQLEKLPYLTAVLKESLRLSHGVVQPMTRVVPREGAYISGHFIPGGSIVGMSSIFVHWNEEIFADARAFKPERWLDPEADLDPWLVAFSKGPRSCLGVNLGWCELYMSIAAIFRRYELKLNGIG
>CYP5142C1 pc.20.56.1
Phanerochaete chrysosporium
MLRLLVDNGLVSALARYGPAMLISIIVWTLGRVVYNLYFHPLAKYPGPRMAAATEWWQAWLEIFKAESLSLTLLELHAKHGGDIVRIGPNELHFSRPSAYHEIYTSKNKWAKNPAFYRYIVSPTESTFSTCEYDKAKKRRDITLPIFSRKSILGMQHLVQECIDSMCENIDKHISEKKSVNILRAFRCCALDAVTSLCFARNTRATSEPEFRAPIEVAMDFSLPLTPVLKHFPMVQVVMSWLPPDVLLWADARLGGFVQLRKMLDAQVEEILRDPDVLASAEHPTIYHAFLAHAPTPSVAELRDEALVYVHAGTDTSSDALAVGTLNVLGRPAVLARLRAELDTVWPRLDERPRYEALEALPYLTAVVKESLRCSHGVVHPMTRIVPRGGARISGAHIPAGTIVAESNIFVHWNADVFPEPHEFRPERWLEGKTPSGESLDNWLVPFSKGPRSCIGINLGYCEIYMTFANLFRRYDLSLDGVKPSDWKWRDCYLPHYLGPEMKVVATPRLS
>CYP5142D1 ug.43.40.1
Phanerochaete
chrysosporium
MAGQLMAHSLDVLSTMFTLLSLYAITRCIYNLYLHPLSRFPGPKLAAATTWWRAIGEVFMWENLTDKLVELHNTYGPCEIVRIGPNELHFSRPSVYHEIHNPRNKWNKDPAVYNVFADTESTVSICNYEAAKRRREMTLPLFSRRSIVDAHDLIRSCLDKMCTNIDSIASSGEPVHFFRAFRCFALDAISLMCFGVSPEASLAPHFRSTLDGAMHVALHDALLVKQFPLLKYLMAYSPQWLVTYTRPALRSYFEMRRVRLSLPTLRQLVYLRSTIAAERSSAGSQEGTPLSEPVLRDEAFVFVNAGADTVSNAITVGVLNVVDNRDVYTKLKHELRCAWPNLKVSPRWEELERLPYLRAVVKESLRMVIGVVHPMTRIVPPQGAVLCDMFIPGGTSVGISHYFLHHNEDVFPQPRTFKPERWLARESDKEHMLVSFSRGPHSCLGVNMAYCELYLAFAYFFRRYDVELNGVRYVHVSSRETELTN
>CYP5142E1 pc.167.13.1 Phanerochaete chrysosporium
MDSWLSWHGVAAAVVAAALLLVVYRVYFHPLAKFPGPKLAAATHWYSAYYEVWRDGALVEHLQELHKQYGPVVRITPDEACISYTDIYVRGTRFTKDPGFYGFMHGDRSSFWMLDPQKSKARRDVLLPLFSRRAVLSLEDVVQKKVRALVTAVLTQGADDTSVNMHRAYRSATLDTILAYAFAQERGMLDVPGFAHPLVREFERAFPLALILKHLPWLHRVSTAVRAVKYMLVRTDPDDIVRDTAAQIDGLLADPDRLAELPHETVFHRFLAPHAKGAGGEPPSRRDIVDEAINIFAAGSDSTGHTCAMGTAFVLAYPEVHKRLVRELEEAWPDRDAEIRLAQLEKLPYLTAVIKESLRMSHGVVMPLPRVVRPNEAIIDGISVPAGAVVGMGATFMHYNPEVFPQPYTFDPDRWLQPDVSRLEQHLVPFSKGLRSCIGLTLAWCEMYLVFGYIFRLLDMQLDNMTLEDIKVKYHFTPTVREKDMLRCMVRARES
>CYP5143A1 gx.20.61.1
Phanerochaete chrysosporium
IILIILATISYRLSPLHPLARYPGPILDKSTSLRLAYLAFIGQRAQYVTELHERYGKIVRIGPNKLSINSLDVVHPIYGSSQAYDKSESYRPGLSAEGSIFFARKKELMRDGDPEGVVESGHKAILMFETYCDSFGEVPALFDILSVLPTGEAYQLVEKRAATHLKDRIKVHPHDGWDMCSFFLAQREGHNYPPMNEVDLNANTVVAFEAGGDTTAGFIIITMFHLLRYRQAYDKLKEELDGAFPTGSVSVEEYSHLAELPYLGAVINEGLRLGAAFPSFPRVVPKGGAMLAGEFIPEGTMVGVPIYTQHYSPDNFWPEPREFRPERWFEDGLGPGTITRQAAFMPFQFGPFGCPGKALGLRLMSVVISNLLVLSYDLSFPPDFDPEAFLNGWINTRTNIFRIPLRVEAKRRPW
>CYP5143A2 PFF_33b(pc.20.120.1) Phanerochaete chrysosporium
MFNSFGPAHVLLPPLALSVIIAVAAYRLSPLHPLAHFPGSWVDKVTSLRVAYFALTGHRAEHVTSLHDKYGVVVRIGPNRVSINSSDVIYPIYASPQAFDRAASYRPGLIHDGSLLFSRKRHWDGALKDRVDQLIDCIARRQDLRGVVDLGEFMRNGDPHNICRSAKDSIVLFEVYSSSLGEIPALFDIASVLPVTAEYRKVERHFQKHINERMQIKSHSDWDFCSFFMAQREDAQYPPLSKPDLNADAMVAFEAGGDTLAGFLSIIIFYILKHQPVYQKLRAELEQAFPLGEIAQDQYASLTEIPYLVAVINEGLRLGANFAGFQRVVPQGGAVLAGQFIPAGTVVGVPAHLQHIHPDNFWPTPLEFRPERWFKDGLGPGTITRQSAFMAFQFGPFGCVGKTFAYRQLNVVLSRLLLAYDLTFALDFDSKAFVEGWLNIRTTIFNYPLKVQASRRQW
>CYP5144A1 ug.24.32.1 revised 8/15/2007 at I-helix micro exon, also removed one
small intron after AGVYL and added a micro exon VDVIPA
Phanerochaete chrysosporium
MELPAHTKYLLACLAFAIFVLLHSKRRRPRYPPGQRGLPLVGNLWDIPTEYAWVKYREIGAQLGSDIIHFEVLGSHYVVLNSDKAVKEVLEKRSHNSSDRPQTVMLQELTGWHRNWALLEYGDYWKDLRRIFSQYFRPSAVPQYHSKQTKAVRRFLNLLLNSPDDFTKHIRYLAASAILDVVYGFDVRPGDPRIELVERGVHTLTDISAGVYL (1)
VDVIPA (1)
LKYIPAWFPGASFKRKAAGWKVLVDAVYEVPYSQYKDAMREGTAKPC
2461961 FAGTLLSEANPDGDLDETFRCLTGTAYV (1)
GGADT (0)
2462165 VSSTLLTFMLAVTMFPETQDPAHEELDRVLGRKRLPDIRDRDDLPYITAM 2462314
LHEVLRWHPVAPLTLPHRLTADDEYEGYHIPAGAVVFGNAWAILHDPATYGDPDVYAPARYLTADGRALRADVPYPLEGFGFGRRVCPGRPFAHDILWLALAHVLAVFRVGRARDAHECEVPPRGVFTPGLISVPEPFGCRFVPRFPGAEELIRQSAMPE
>CYP5144A2 ug.24.29.1
revised 8/15/2007 at I-helix micro exon and at VDVFPI,
AND KQSIMVNEL, AILRDED, Phanerochaete chrysosporium
MEDTSRSLVGPSLWAVFALGLLFAFCLRRQPRYPPGPRGLPIVGNVFDIPMNVGWKVFRDVSRCFESDVIHYEALGSHLVVVNGAKAAKELFERRANNYSDR (2)
KQSIMVNEL (2)
TGWHRNWGQLEYGDRWRQHRRLFHQHFRPMAVSQYHPRQVKGVRVLLRALSESPEDFQRHIRFMAGATIMEIVYAYDAQPGDPRIKLVEDAVDTLTFVVNAGVYL (1)
VDVFPI (1)
LKYVPNWFPGASFKRQAAEWKKLVDALYEQPYQEFKATVKEGN
2465265 AKPCFAATLLSSVENDEDIENLEELFMGLTGTAFV (1) 2465369
AGSDT (0)
2465493 TIASLNVFILAVTIFPEAQRSAQEEIDRVLERKRLPTMEDKVLLP 2465627
HVTALVHETLRWHPPLPLAAPHRVIEDDEYEGYFIPAGTTIIGNAW (2)
AILRDEDLFPDGDSFKPERWLNEAGALRDDLPYPMETFGFGRRICPGRHFANDVLWLAIANILTVFSIERALGEDGQPIVPEAKFSPRLISK
PEPFKCAFKHRFSGAEDMIRLAAIVEE
>CYP5144A3
genewise2nd.24.5.1 REVISED AT PRSVMLHEL 8/16/2007
Phanerochaete chrysosporium
MELPPVPHPLIAYLCAGLLLAGLVVTRLRRRRHYPPGPKGLPLIGNLFDIPTDYAWKIYRAFGDQYGSDIIHFEIFGTHLVILNSAKAARDLFEKRSSIYSDRPRSVMLHEL
TRWGRSFGFMQHGDEWREHRRLFNMHFRPSAIAQYHAKQKSAVCTLLRSLLDAPEQFREHVHFMAGDVIMGIVYGFDVQPGDSRLQLVEKAVMTLNQIVNAGVYL
(1)
VDVIPA (1)
LKYIPAWFPGAGFKRHAAEWKKLVDDMFEIPYRESMKSLQEGKCESSFAASLLAQLEGQESPDNIERIAMDVLGTTYVAGSDTIITATSTFLLAMILHPEVQITVQAELDALLEGARLPNISDKAALPSVTAVLQEVLRWNPGLPLVPHRVVADDEYKGYHIPAGAAVIGNTWAMLHDETTYPDPEPFKPQRFLNEDGTLNADVPYPTDVFGHGRRMCPGRHFAHDMLWLTIASILTVYKVERDVDEDGQEITPTASFTSRVPTPFRCRFTPRSASAESLIRSSGVSTE
>CYP5144A4 pc.24.8.1(gx.24.6.1)
revised at micro exon 8/15/2007
ADDED KQQSVMIHEL AND REVISED
LAST INTRON BOUNDARY 8/16/2007
NOTE THIS GENE IS COMBINED WITH
CYP5144A5 IN JGI BROWSER (e_gww2.1.398.1)
Phanerochaete chrysosporium
MEQSTLHILPYLCASIPVLVCLLVLRLRRPHYPPGPKGLPLVGNLFDVPLSHGW
VAYRELAKQYGSDVIHLEILGSHIVIINSAKAARDLFDKRSNIYSDKQQSVMIHELTGWHRN
WGFMAYGDYWRKHRRLFHRHFRPAAVPQYHSAQAKGVHNLLKLLMRSPERFREHIRF
(2)
2473972 MAGSTILDVVYALDVQPGDSRIELVERAVHTSTEIVAAGVYL
(1) 2474097
VDLFPI (1)
2474217 LKHIPSWVPGAAFHRKAAAWKALVDRMYEEPYNQFKASM
2474333
KDGNAKACLTASLLMEAESTHQLDAIEDILISVTGTAYGAGTDTAVASLNTFMLGITMFPHTQLAAQDELDRITARQRLPTMEDRENLPHVTAILQEVLRWNPAAPLGLPHRTVRSDEYNGYFIPQGATIIGNSWAMLHDEAIYPDPGSFKPERFLTEDSTLRSDVPYPIEAFGFGRRICPGRYFAHDLLWLTIAGILAVFRIERARDEQGDEIVPAGDFSPRFIS
(2)
SPEPFQCRIVPRFAGAEALIHGTGLLG*
>CYP5144A5 pc.24.9.1(genewise2nd.24.7.1) Phanerochaete chrysosporium
NOTE THIS GENE IS COMBINED WITH
CYP5144A5 IN JGI BROWSER (e_gww2.1.398.1)
MEWSLSLGYALLGLGIMWVVKYAQRPRRRYPPGPKGIPILGNVFNIPLENSWISFDQWSRQYASDIVHVEALGKHVYVVNSARAAKELFDGRANVYSDKEQSVMMLELCGWSRSWAMLPYGNYWREHHRLFHQHFRPQSMVRYHEKQRRGARRLLQLLLDTPEDYEKHMRYAAGSTILDVVYSFDVQPNDPRIELVEAALGTANDLMHAGIYL
(1)
VDIFPL (1)
LKHIPTWFPGAQFKRLAAKYKRLVDNMYTVPYSQLKASVKLGTAQPCLVASLLSEADEHVTPERDEIFMNLAGTTYAGGTDTIVIALSIFILAMILHPEQQVAVQKEIDRVVGRDRLPELADRESLPRVTAVIQEVLRWHSPLPLATPHRATSDDEYNGYYIKAGSVVIGNAWAMLHNENVYPDPASFKSERFLTPDGKLRDDVPFPIEAFGFGRRICPGRHFALDSLFLLVSHILAVFTIEHAVDADGHIIPVEPEFEPQAFSPPKPFKAQFKLRFLAAEDLIDGSALE
>CYP5144A6 pc.24.10.1 revised at micro exons 8/16/2007
Phanerochaete chrysosporium
MLTALSCVFAEALAVWAVSSWTRPRHEYPPGPKGLPFLGNMFDIPMKYGWVTFANWSRLYGSDIVHVQALGKHIYVINSAKVAKDLFDGRPHIYSDK
(2)
EQSVMTQEL (2)
SGWKRAWALSPYDDEWREYRKLFHQHFRPSAVQQYHHKQTKAVRRLLQLLLDTPEDFLAHLRYAAGSSLLDVVYSVDALPGDLRITLVEKAVHTFAKLLETGVYL
(1)
VDVAPI (1) LKHIPAWFPGADFKRQAAEYRQLVDDMFKVPYQQFKDAWRRGTAQPCFAASLLTDADPLDGSEHEELFINLTGTTYAAGSDTTVAAMSTFMLAMALHPEVQRWVQEELDRVVGRGRLPEMADQPALLRVMATVHEVLRWHPPLPLATPHRAMADDVYAGFTIPAGSIVLGNSWAILHDDKTYTNPHTFDPRRFVGPNAQPFPEVVFGHGRRECPGRHFALDILFLAVAHVLSVFAIERVDNSDPGIGDIQGLFTPHVLSYPKPFKASFKPRFPGVESLVRTAALSEI
>CYP5144A7 pc.24.11.1 This is hybrid with
genewise2nd.24.9.1|whiterot1 in second half
(GENE IS SPLIT IN GENOME VIEWER) Phanerochaete chrysosporium
MSRFLYDYSTLLYLCAGITFVVLITLSSRPRRRYPPGPKGLPIVGNLFDVPTDHGWKRYQEIGKEYGSDIVHFQVFGSHIVVVNTAKAARELLDKRSNIYSDKQRSVMIHELTGWHRNFSLMPYGEGWRTRRRLFHQHFRPMAVPQYHTRQLKAVHGLVQSLFEAPQNYKEHIRFMAGSAILDIIFAFDIQPGDPRIEIVEKGVQTATEFMCSGVYL
(1)
VDVFPI (1)
LKYLPSWFPGAGFKRQAAKWKALVDDMHEIPYYQFKQTMREGKAKPCFASTLLSSAAENDKDSLESLDEIFMSLTGTAYVAGSDTTISALNTFVLAMTMFPETQAAAQEELDRVLGRKRLPDFDDRDSMPYLTAMVYELLRWHSVLPLGLPHRTLADDEYNGYFIPAGTVIVGNCWGMLHDDDLFPDPDIFRPERFLNADGTLNSDAHFPIETFGFGRRICPGRYFAQDLLWLTIANVLAACSIERVVDEKGFEVRPTGDMTPRVLSMPEPFECNIRPRFSGAEALVRSACLND
>CYP5144A8
genewise2nd.24.9.1 = Scaffold_205i revised at micro exon 8/15/2007
AND AT QQTVMIHEL Phanerochaete
chrysosporium
fgenesh1_pg.C_scaffold_1000787 [Phchr1:787]
MEALASRITVYLCAGVVLVYVFSRVFKRRPHYPPGPRGLPIIGNLLDVPSLYGWIAYKNLGDQCGSDIVHLEVLGSHYVVLNSAKAARDLLDKRSNNYSDR
(2)
QQTVMIHEL (2)
TGLERGLGMLPYGDYWRLHRRLTQQHFRAAAVPQYHARQAKVVRKLLHSLLDSPERFMDHIRFMAGAIILDIVYALDVHPGDHMIEVVETAMGRINEIINAGVFL
(1)
VDVIPV
(1)
LKYLPSWFPGAGFKRRAAAWKVDIAPMFEAPYERFKQSLGGTTRPSFAGNLLSRVQNEEELSQLEDVFMNITGTAYGAGSDTTLATLTGFVLAMTIFPEKQLAAHAELDKVLERKRLPEVEDMQYLPSITALVYEVLRWNPAAPLGIPHQTIVDDEYNGYFIPAGTVVIGNAWAMLRDPNTYPDPDTFKPERFLAKDGSLRDDVPYPTEAFGHGRRICVGRHFAQDVLWIAIAHILTVFRIERAVDEDGREIVPVPDYTPHFVTMPKPFKCRFTPRFPGAEGLIRSAADASNE
>CYP5144A9 pc.83.7.1
revised at micro exon 8/15/2007, Phanerochaete chrysosporium
revised at RQSTMMLDEL and EFTARIVS
8/16/2007, EST = DV758101.1
MAVLLAAGYYILSVAVFILLYNASRRRQRLPPGPKGLPLIGNLFDVPNDYAWLRYKELGQQYGSDIVHMQALGNHILVLNSMKAAVEILDKRADISSDRQSTMMLDEL
SGLGRAWTQLGHNDSWRIHRRLFHQHFRPSAISQYHTKQTKAIHRMLSFLRESPAQYMDHIRFMAGSMILDVVYTLDVQPGDYRIKLAEMVAHVSTEVFTAGVWM
(1)
VDMIPM (1)
LRHLPTWFPGAGFKIQAAKWKTTVDRSYDIPYEQFKASMHEGGGEPCLASALLSSAEDVEELERMDKVFSSLTGTAYIAGTDTTVSTLASFVLAMTIFPEAQLAAQAEIDRVLGGTRLPDINDKANLPQVTAILYETLRWNPVLPLALPHRTTADTSYDGYYIPAGTVVLGNSWAILQDETLFPEPQLFKPERYLNGDGSLNSSAHYPIETFGFGRRICPGRYFAQDAVWLAIAHILAVFKIERARDGDGKEIVPTPEFTARIVS (2)
MPKPFECKFKVRSPQAESLIESAALGG
>CYP5144A10 pc.83.8.1
revised at micro exons 8/16/2007
Phanerochaete chrysosporium
MALLVYFCAGLVPVLLLVLGLRKRPRYPPGPRGVPIFGNIFDVPMKYAWLEYVKYGQQYKSDIVHFQVLGQHIVVLNSLQAVGDLLDKQSSIYSDR
(2)
VPSVMLNEL (2)
TGWSRSWVQMEYGDQWRMHRRLMHQHFRSTMIPQYHPKQTKAVRRLIQSLLEQPEHFMEHVHFLSGSLILDVVFSFDVRPGDAILALAERAVDTTKAIIAAGVWL
(1)
VDVVPI (1)
LKYIPSWFPGAGFKRIAAKWKTDVNKMFDVPYAKFKDSMREGSATPCFASALLSGAEDDNGGVIDNQDEVFISLTGTAYVAGSDTLSDALSTFLLAMIAFPEKQRAAHEALDCVLERKRLPGVEDRDALPHITALAYEVLRWHPVVPLSIPHRTTADSYYKGYYIPAGSTIFPNSWAILHDEALYPEPHLFRPERFLNEDGSLHAHARDPIEAFGYGRRICPGRHFAHDALWLAIAHILAVFKIERALDVDGNEIEPKLDFMPHFLSMPKPFKCRFTPRFPDAANLALSASSDY
>CYP5144A11 ug.83.30.1 revised at micro exons and after EXXR motif 8/16/2007
GC boundary at HIRY, added C-term Phanerochaete chrysosporium
MGWTLCLYALLGLTGLWVAARVRRPRQRYPPGPTGLPVLGNVFDVPLENGWLVFDQWARQYDSDVVHAEALGRHIYVVNSAKAARELFDGRPHVYSDK (2)
DQSVMLLEL (2)
SGWWRSWVMLPYGDYWKEHRRLFHQHFRPQSLPQYHEKQAKAARRLVRLLLDSPQDYAKHIRY (2)
ATGSSILNVVYSFDAQPGDPRLELVEAAMGTANELMHTGVYL (1)
VDIFPV (1)
LKHLPMWFPGAHFKRQAARYKRLVDDMFEIPYAQLKSSMQEGTIEPCFAAALLSEAEDSASPERDDMFMNLAGTAYAAGTDTIMMTLLTFILAMVLHPEEQAAVQEEIDRVVGRDRLPGLADRESLPRVTAVIQEVLRWHPPLPLA
TPHRAASDDEYNGYHIPAGALVLGNCWAMLHDARVYPDPDVFRPGRFLAAGGDAPRADVPLPAEAFGFGRRICPGRHFALDSLFLFVAHLLAAFRIEHAVDAEGNVVPVVAAFEPQAFR (2)
SPPKPFKARFTLRYCGAENLVRGGVRAG*
>CYP5144A12 pc.16.82.1
revised at micro exon and added one exon before it. 8/15/2007 Phanerochaete
chrysosporium
fgenesh1_pg.C_scaffold_8000230 [Phchr1:5055],
added N-term 8/16/2007
added RTHSVMLNELSGWAE and WYTPFPLG and C-term
exon 8/16/2007
MELWFDFPSVVTYVLAA
VSCASLLILHTRRRPRYPPGPKGLPIVGNLLDVPTHNAWIKYKQLGKKYGSDIIHFEVFGSHIVVLNSTTVARDILEKRSQISSD
RTHSVMLNELSGWAE
ERNFGFMRYGDGWRRQRRLFQQHFRRKAVTQYHAIQSKSVHSLLNALLDRPERFIANLRF
(2)
MAGSMILRIVYGTDIQPGDSRLTLVEKAVGTLVEVMNAGVFL (1)
VDVFPI
(1)
LKHIPSWMPGAGFKRKAAEWKVLVDDMYEVPYNVGTLSIFFLAMTIFPSVQVAAQEEIDRVLGRKRLPSIEDRNALPRTTAIVYEVLRWYTPFPLGVPHRTIADDEYNGYFIPAGTTIIANAWYAMLHDEERYPNLETFIPERFLNKDGSLRSDACIPLEPFGFGRRICPGRYFAEDIVWLAIASILSVFRVEPPVDEHGEPLKQTATFGTRFLS
(2)
PAPFKCCFTLRYPEAEGLIRASATSTA*
>CYP5144A13 pc.16.83.1 = GX.16.34.1 (USE THIS MODEL) = SCAFFOLD 4e
fgenesh1_pg.C_scaffold_8000229 [Phchr1:5054] ver2,
ESTs = DV761651.1, DV753979.1 Phanerochaete chrysosporium
revised at micro exon 8/15/2007, revised at AHSIMLNELS and C-term 8/16/2007
REVISED SEQ = 50% TO CYP5144A8, IT SITS NEXT TO 5144A12
MTTLALASSLTYLFAGVLLVCLFVSYARKRPRYPPGPKGLPLIRNLLDIPADYPWITYRDLAEKYNSDILHFEVFGSHLVVLNSAEATRQILEKQSSITSDRAHSIMLNELSGWDTDRTVTFMEYGESWRRHRKLFQEHFRQQAIPRYHHAQTKGVNRLLKSLLDTPEKFSAHIRFMSAYTITEVVFGKEVGPDDPSIEVVDDGMHTLNELLNAGVFL (1)
VDIFPL (1)
LRYVPSWFPGASFKRLAGKWKKAVDDMYTIPYNNYKATLGEGDANTCLLATAMADKVD
QDDARVVDHDLMCLAGTTFGAGYDTTATALGIFIMVMAVHPEAQISIHEELDRVLHRDRL
PTMEDRKELPRTTALMYETFRWHLPLPLG
VPHQTTAAIHYNGYFIPQGANIVANSWAILRDEGLYPDPETFKPERWLDADGSLRDDMRFPVEMFGYGRRICVGRHFAEDIVWLAIASILSVYKIEPPVDENGTVRALEADFTPRLFSAPKPFKCRFTPRFPGAEGLIRASL*
>CYP5144A14P pc.24.16.1
= gx.24.13.1 PSEUDOGENE MISSING
C-TERM
revised at micro exons 8/16/2007 Phanerochaete chrysosporium
MPDCTTIGYLLASVALAYALASRHPRSSRYPPGPRGLPLLGNLFDMPRKHSWTKHQELSKTYESDVIHYQVLGLHIMALNSGEAVRDLLNKRSTIYSDR
(2)
QETVMLHEL
(2)
TGWHRNWALMRYGDAWKERRRHFHEHFRPQAVSQYNFKQVKAARILLNSLLESPRAFSEHIRFMASSLILDIVYALDVRPDDPEARRVERALETLAEISASVFM
(1)
VDLIPV (1)
LKYLPSWFPGAGSKRQASIWKNIVDEMFETAYQVCKNSAQHEYVRPCFTTALLSEVSDPANMKEMDEIFMSLAGTTYI
(1)
GGSDT (0)
>CYP5144A15P PSEUDOGENE pc.24.17.1 64% TO 5144A1
IT APPEARS THAT 5144A14P AND 5144A15P WERE PARTS OF A SINGLE
GENE DISRUPTED BY A TRANSPOSON CONTAINING A RETROVIRUS-
RELATED POL POLYPROTEIN THAT NOW LIES BETWEEN THEM
Phanerochaete chrysosporium
AQSAARSSTASTEQINATLNTWMLAMTLFPDTQVAVQDELDMVLGRKHLPSIEDRDSLPRVTAMLHEVLRWHPVGPMGVPHRLTVDDEYRGYHIPAGTIVMINAWAILHDESVYPEPDIFRPERYLDSDGRLRTDMPYPVEGFGAGRRLCPGRHFAHDMLWLAIAHVLTVFRIERAVDEDGREIVPEAKFEPWLIRCASLCVGVPCTAHLAVSPPEPFQCQTKLRFPEAEGLVHLAAMDE
>CYP5144A16 NEW SEQ 2588519-2588442 REGION (-) STRAND SCAF_1
68% TO 5144A5 AA 311-336
e_gww2.1.906.1 [Phchr1:132380] Phanerochaete
chrysosporium
MEGIPILSYVTLGLVTVWTILSLRKPRRRYPPGPKGLPVLGNV
FDIPLENGWLIFDKWARQY (1)
GSDIVHVEALGKHIYVINSAKVAREIFDGRPHNYSDK (2)
EQSTMLLEL (2)
SGWGRSWVMFPYGDYWRQHRRLFHQHFRAQSIPQYHQKQAAAA
RRLLQLLLDTPADFAKHIRY (2)
ATGSSIVDVVYSFDTPPGDPRLEIVEAAMGTASELLHSGIYL (1)
VDVFPI (1)
LKYVPAGFPGAQFKRKAAHYNKLVKDMFTIPYTQVKTAM
KEGSVQPCFTTALLSESDDLDTPERDKIFQSLVGTAYAAGTDTLMISMLTFMLAMVLHPEAQT
AAQNEIDSVVGRDRLPGMTDRDSLPRVTALIQEVLRWHCPMPLATPHRAIVNDEYNGYHIAAGSVVIGNA
WAMLHDEDVYPDPHSFKPDRFLTTDGRLRDDIPFPIEAFGFGRRICPGRYFAMDALFLFVSHVLAVFRIE
HSVDAHGNVVGVEAEFQPQGFRCA*
>CYP5144A17P gx.24.12.1
49% TO pc.24.17.1, 57% TO 5144A5
scaffold_1:2496394-2495844 (-) strand Phanerochaete
chrysosporium
2496394 IADREPLPPVTA 2496356
2496230 HTPRYERRHSGYYMSAGLLVIGDTWY (0) 2496153
2496068 RFLMAERALRTDVTFPIEVFGYSRRICLGRQFAKDVLFLAISNILAIFTI
EKAVDEHSGSIEVQNAFLPHAIRCA 2495844
>CYP5144A18 fgenesh1_pg.C_scaffold_1000782 [Phchr1:782]
same as Scaffold_205c gene model complete,
revised at micro exons VDLIPI (1)
and PQTVMLHEL 8/16/2007, 62% to 5144A1
GC boundary at PGLIR
Phanerochaete chrysosporium
MESLTLRNCASAFLAG
LLVLACGLVLRPRRRPRYPPGPKGLPLVGNMLDIPTEYAWERYYELGKEY
GSDVLFFRVLGSHFLVLNSAAAANELLEKRANVYSDR (2)
PQTVMLHEL (2)
TGWDQNWAFWEYGEGWKQARKMFHQHFRPSAAPQYHLKQ
TKAARRFVKLLLESPASFAQHAR
FLAGSAILDAVYAFDVQADDPRIALVERGVHTLVEISRGVFL
VDLIPI (1)
LKYIPSWFPGAGFKRQAAQWKDAVDATYSDPYRQFKTLL
RNGQAEPCVAASLLSSSGDEPSGALDDLLKSVAGTAYV
GGSDT
VSATLTTFILAMTMFPDAQAAAHAQLDEVLKRTRLPEMADRAALPYITAILYEVLR
WQPAGPL
GLPRRLMADDEYRGWHIPAGTVVLPNIW
AMSHDPGTHAVPAQFVPARYLAADGTLREDVPCPADVFGFGRRVCPGRPFAQDVLWLAI
AHVLSVFRMEGPMGERGEIRHSRLFTPGLIR (2)
LPEPFACSFRPRFPGAENLVDAGVVG*
>CYP5144B1 pc.23.12.1 revised at micro exon AND PHAPIVSTIL 8/16/2007
e_gww2.8.230.1 [Phchr1:138753] Phanerochaete chrysosporium
MLDTTPFTLALLTVGAVCLLGLIKGASRRRRLPPGPKGVPLLGNIFDAPKEHEWRTFKEWGRTYESDVVHFGILGTHYVVLNSAWAALDLMDKRSHNYSDN
(2)
PHAPIVSTIL (2)
TGWDRNWGFMKYGDYWRAHRRMFHQHFRPNAVSAYHSTSQQAVRELLRLLYAKPEHFKEHIQHMTGYNIIKLMFGVAVSPEDDPILARMENALRILGKIANPGVYL
(1)
VDSFPL (1)
LRFIPSWVPGAKFKRDAEAWKPVIDKTYTQVYEEIKTSYANGSPVPCLVTEMLEDVLKVDNEAYRDMLEDVIINGGGTAYVAAYDTSSSVLSTFVLAMLLYPDVQRTAQEELDQIVGPDRLPTMEDQPSLPYVTALATEVLRWRPALPIGVAHKSVVDDEYRGYHIPGGSVIIPNVQAILHDEGSFPDPDTFNPRRFLDSEGQQLEELTGIVSAAFGFGRRICPGRYFAKDVVWLTIASVLSTFNIEKHFNEAGNAVEPSGEYTPGIISYPAPFKAAFKPRSESAVELVR
>CYP5144C1 ug.83.31.1
revised at micro exons 8/16/2007
fgenesh1_pg.C_scaffold_1000766 [Phchr1:766] Phanerochaete
chrysosporium
MFSALVLSLLLAAALFLRFRRKRYPLPPGPKGLPIIGNARDIPKSFPWYTYDRWSREYNSEIIYLRLVGTDVIVINSEKAANELLNKRSTIYSDR
(2)
EHMTMLLDL (2)
VGWGGRNFAFAHYGDLWRAHRRLFHQYFHPGAVPAYHAKSTLEVRRLLPRLLSHPDDFMQSIRTMTGAIILGITFGMELQPENDPFVALAEEALHAMAQVGNVGSYI
(1)
VDYLPW (1) LQYLPSWAPGAAFKRQAAKWNKIVLEMYEKPFQTIKQALARGEAPPSILTSMLETLDPEEDNAARESDMRHVTGTAYTAGADTTVSSLGTFILAMLLHPEVQRRAQEEIDRVVGSDRFPEYDDRDSLPYITAIMKETLRWRQVTPLAVPHRLRVDDEYNGYHLPAGSVVVGNSWAMLHDEERYPNSDLFDPTRFLTPDGELDPDAPGPELAAFGFGRRICPGRYFAMDSMWIAMAHILATVNIEKAVDDAGNILEPSGEYTYPVPFKVAFKPRSAAADALIQGGTPLA
>CYP5144C2 pc.83.19.1 revised at micro exon 8/15/2007
fgenesh1_pg.C_scaffold_1000761 [Phchr1:761]
REVISED EXXR REGION AND PSHTLLVTV, and E*LTYAKWSREC (1)
Added C-term
8/16/2007 Note: there is a stop codon in a conserved region, possible pseudogene Phanerochaete chrysosporium
MDIPVPYAFIVVGALVLFFRLRKKPRFPPGPKGLPIVGNALDLPKAR
E*LTYAKWSREC (1)
GSDIIHLRFFGTHVFVLNSVKVVNELMVKRSAIYSDR (2)
PSHTLLVTV (2)
TGWQRNFTFVDLGDHWKARARMFQQNLGTSTISKHRPKLIEGNRKLLLNLLLSPDDFMKHIRYLSGSSILGIIYGIEVQQDHDPFVETAEKALQCLAAVINAGSYA (1)
VNYVPI (1)
LRFLPTWAPGAQFKRDAAEWYKYVTALIDGPYTYVKESLANGENNTSIVGTLLQELSDDEKRSEQEDTIREAFGTAYTGGVDTTYSSVNSFILAMLKYPDVQRKAQEELDRVIGRDRLPSFDDRDALPYITAIVKETLRWGLVAPLAAPHQLRVDDEYEGYFLPAGSVIIGNAWAILNDEKRYPHPESFIPERYLTTDGTLDSSAPDPMEACFGFGRRMCLGRYFAFDSLWIAVASLAAAFHMEKAVDESGLVIEPSGEYTSGTAC (2)
YPLPFKAVFRPRHEGVVALIKADVSESDSL*
>CYP5144C3 pc.20.52.1
revised at micro exons 8/16/2007
Phanerochaete chrysosporium
MDDIVLVLLVACAVALYARTKRTRYRLPPGPKGLPILGNTYDIPAKYEWLAYEKWSRDFGSDIICLKFVGTPVIVLNSIQAINDLLEKRSSIYSDR
(2)
PVTVMAYEM (2)
VGLDRNFGFVPYGDVWREHRHLFHQYFRLDMVPKYHDRMLKHSKDLLQRLLVSPDRLMEHLRFSVAGASILNISYGIDVQPENDHYIAVADEAIHALAVTGNAGSYL
(1)
VDYLPL (1)
LRYIPAWVPGAKFKRDAANWWEKTRLMIDEPFNYAKQRMAQGKGMDCVTAVMLSAIGEDQDREHQELLIKQVLSVSYIGGADTTVSALATFVLAMMQNPKMQRIAQADIDRVVGGERLPSVEDRDSLPYVTAIVKEALRWRPVIPLAVPHRVTVDDEYKGYHIPAGSIIVGNVWAVLHDETRYPNPDVFDPTRFLTSDGQLDNNAPDPAEACFGFGRRICAGRYFALDAVWLSVACILATFDIAKPLDENGNPIEPSGEYTTGLLSHPVPFKVSFKPRSAAAEALVREPISRDL
>CYP5144C4 gx.20.26.1
revised at micro exons 8/16/2007 Phanerochaete chrysosporium
MDYLGISILLVAALALHYFLRKKRYRLPPGPKGLPILGNALDIPAKHEWLAYAKWGQECGSDIIYLNLAGTPVVVLNSAKAAKDLLEKRSSIYSDR
(2)
PVTVMAHEL (2)
IGLGRNFGLKPYGDTWREHRRLVHQHFRTENVPRYHEFTSKQIGRLLLHLLEDPSNFVRHLRIMAGASILRICYGIDVQPDNDHYLSVADEAIESIAATGNAGSYL
(1)
VDSLPI (1)
LRYLPSWAPGAQFKRDAAKWKEKVDRMIAEPFDYAKRYMASTEGAATDYIAGLLLSAMDPGRDKTQQEIAIRDSLWAAYVGGADTSVSALATFTLAMVLYPDVQQTAQAELDRVLGKDTLPTIEDRDSLPYVTAVVKETLRWHPVTPLAVPHKVTTDDEYRGYHIPARSIVVGNVWAILHDPDRYPNPESFEPSRYLTSDGLLDPAAPDPTEACFGFGRRICPGRHLAYDTIWTGIASILSSFDISPPLDEQGKPVNPSEEYTTGMLSHPVPFRANFKARSENVEALIRRITLCE
>CYP5144C5 pc.20.54.1
revised at micro exon 8/15/2007 and EIMVMCHEM
Phanerochaete chrysosporium
MQTVVLAILFVFAIALPIYSRRKRYRLPPGPRGLPIIGNILDIPAGREWLTYAKWSREYGSDIIYLNMAGTPVYVLNSIQATTDLLEKRSSTYSDR
(2)
EIMVMCHEI (2)
VGWGKNFAFQPYGDFWREHRRMFHQHFHPEAVTKHHVHILKQAKDLLQRLLVDPDDFMQHLRFMAGAAILRVSYGINVQPENDHYIGIAERAIHSLALTGNAGSYL
(1)
VDNLPI (1)
LKYLPSWAPGARFKRDGEIWRREVDQMFSEPFELVKRQMVGADGEPPDCVTASLLTTLDERKDRPREELEIAVKQAVGTSYVGGADTTVSSVATFILAMLQFPDVQRTAQAEIDRVVGSTRLPTIEERGSLPYVTAVMKETLRWNQVTPLAVPHKVTVDDEYKGYFIQAGSIVIGNSWAVLHDETRYPNPEAFDPTRFLTPDGKLNPSAPDPVEAAFGFGRRICPGRHFAMDAIWMNLAFILATFNIEKPLDEAGRPIEPSGLYTPGLLSHPEPFRVKFIPRSKAAEALIRETMFYD
>CYP5144C6 pc.20.55.1
revised at micro exon 8/16/2007 and VVTTMAHEM
Phanerochaete chrysosporium
MENITFAVLFVLLLAVPLFFKRQRYRFPPGPKSLPLIGSVLEFPVQSSWLTYQRWGRELASDIIYLNVLGKHIYVLNSAQAVSDLLEKRSGTYSDR (2)
VVTTMAHEM (2)
VGWDKNFALQPYGEFWREHRKAFHQQFQPDMVPRYHVHMYKQAKDLVRRLIAEPNALKQHLRYMAGALILRVSYGIDAEPNDDHYFEIIEQAVYSLTEVANTGAYL
(1)
VDFLPF
(1)
VKYVPSWMPGAQFKRDATEWAPQVNQMFDEPFDVVKRALAEGNAPDSVCAALLSELDPRKDRAHQETVIKQAVGTAYIGGADTTVSTLSTFVLAMMTHPDVQRTAQEHIDRVTGGDRLPTIEDRDALSYVTAIIKEALRWRPVLPMAVPHITTADDEYRGYHIPKGSIVMGNAWAVLHDEARYANPDAFDPTRFLTPAGTLDKDAPDALEAAFGYGRRVCAGLHFALDSMWVNVACVLATLDIRKPVDEHGVPVEPSMAYTTGLLEQPEPFAVVFKPRSQAAEALIYEGHDD
>CYP5144C7 pc.142.5.1 ,
e_gww2.9.179.1 revised at micro exon 8/15/2007
revised at RLHSTMLHDY 8/16/2007,
ESTs = DV760024.1, DV759090.1
revised region after EVLR WRPVAPL Phanerochaete
chrysosporium
MDTLLLAGLVAVAVVAAGCLAHSRRQRFPPGPKGLPLLQNLLDVPRHRPQWEAYRDWGLKYNSDIVHLRLFGVSFVIVNTADAVTELFSRRSSVYSDR
(2)
LHSTMLHDY (2)
IGWEKAIVMKNYGEDWREHSRLFHQSFQPKVIQEYYPRLYEEARKLLPRLLKGDDFVASLRVMTASAILGVTFGMEINDSNDPYVTIADRAIQSLVEAGMPGSYM
(1)
VEYIPL (1)
MRYIPSWAPGGKFKRDAAEWRTLVSDMFTKPFEHIKSAIRHGVARPSIATSLLMGLDDKQDNARREHVIRNVTGTAYVGAADTTVAALRTFILAMVMHPAIQKAAQAELDRVVGRDCLPTFADREHLPYLTAIQYEVLR
(2)
WRPVAPL (1)
GFPRRANADDEYHGYHIPKDAIVLGNIWAILHDPARYRDPAAFDPARWLTPDGALRADAGDAMLAFGFGRRICPGRHYAVANMWINMAYMLAAFDIAPPRDAAGRAVPPAGEHTTGLLTYPKPFGAVFTPRSAAALRLIVADADD
>CYP5144C8 genewise.35.22.1
= GX.35.9.1 revised at micro exons 8/16/2007
e_gww2.4.188.1 Phanerochaete
chrysosporium
MGVLILCAIAILAALLCYHHFRARRFRLPPGPKGLPIVGNVLDVPKDGPGWLTYERWSHEYGSDVIYLNLLGSSIVILNSSKATTDLLDKRSPIYSDR
(2)
QRLTVLHDF (2)
VKGDRAFAFLGYGDEWRQHRGIFHKYFHGQAVHNFRPKMLEEARKVLVRLQSTDDYDRCFRVMSAASILGVTFGMDIEDINDPYVVLAEEAINYVLSAAIPGSFV
(1)
VDSLPL (1)
LKYLPAWAPGAGFKCKGAEWHDLVSRMILTPFETLKQKMAEGTAKPCIATAIVQKLEESKGGDAQRETQIAQYVTGTAYTAAADTTVSSLCTFILAMVLNPEVQALAQEEIDRVIGTTSLPDYTYRDSLPYVSAIMYEVLRWRPVAPLGVPHRLMEDDEYEGYHIPGGSLVVGNIWAITHDPVRYLNPDAFDPTRWLTTDGQLGDVTDALVAFGFGRRVCPGRHYALEALWITLVHVLAAYRIEPPVDAHGRARPPSGEYLPGFIAFPAPFKAVFKPRSPVALGLIQTALG
>CYP5144D1 pc.24.13.1
(genewise2nd.24.10.1) revised at micro exons 8/16/2007
Phanerochaete chrysosporium
MLDRSVLLPCLVGIVAAIIIVSRRGRERYRFPPGPKPLPLIGNLLDAPTDLGWYTYAKWARQYHSDIIHFEVFGQHFYILNSVRVAKDLLERRSQVYADR
(2)
QQSVMVQEL (2)
TGWHRVFSMKAYGESWRQQRRLFHQHFRQQAIPEYHAELTNGARMLLRSFLESPNHFLEHIRHISGGTILAVLYGIDVDNYSAERMESIEKAIEIVTEIADGGVYL
(1)
VDFIPL (1)
LKYLPTWFPGAGFKRRAAEWRVHVETMFEAPYGDVKRDMKLGKAKPCVATKLMSAFGDKAEDPEIEELLICVTGTAYAASDTIVFAMIAFVRAMMVFPEVQCKAQQELDRVVGRDRLPVISDQASLPYLAAVTKELLRWHPITPIAVPHKSTTDDWYDGYYVAAGSIVIANVWAMFRDEERYPDPEAFRPERFLTAEGTLDPAVPDPVEVFGFGRRMCAGRHYVDAALFLAIAHVLHALTIEKPRDARIPVVDPPPGYALSRLFWAPEPFEADIKPRFEGVERLMQMSSLHSF
>CYP5144D2 pc.24.14.1
revised at micro exon 8/15/2007 and at QLSVMACEL
Phanerochaete chrysosporium
MLSSTILVFSSVCTLAAIVAIVRRFGGKRRHHFPPGPKGLPIVGNLFDVPTNFGWYTFAKWAQQYNSDIIHFEVLGKHFYVLHSAALAKELFERRSQTYSDR (2)
QLSVMACEL (2)
TGWHRVLTLTPYGEYWRQYRRLFHEHFRAQVIPQYEDKMLTSARNLLRLLLETPDRFLRHIRHASGRTMLDIVYALDTEAHNNAVILESVEKAIEIFAEVAEGGAYL
(1)
VDHIPI (1)
LKYLPAWFPGASFKRQAAAWRVHVDTMYEAPYQDVNRRLLAGKAKPCITTSLISAFSDKCEDPDVEESLISFAGTTYAGSDTSVFKMTIFMRAMLLFPEVQVKAQEELDRVVGRDRLPELADKDSLPYISALYKELLRWHPLFPLAFPHKSTVDDWLDGYFIPAGSLIIGNAWATLHDEERYPDPEAFRPERFLSDDGKLDPSVPDPVEAFGYGRRICPGRHYADASLFLYIAHILFAFTIRKPLDERGNVIEPPPGVPEPFKASIKPRFEGVEELIQLSTQLATSD
>CYP5144D3 pc.24.18.1 revised at micro exons 8/16/2007
e_gww2.1.419.1 [Phchr1:133291] ver2 Phanerochaete
chrysosporium
MFDNGVTIALLLIGVTLLVAEALKKRHRFPPGPKGLPIIGNLLDVPKDYHWLTYTAWSRQFDSDIIHLEALGQHYFVISSVDVAKDIFEGRSQLYSDR
(2)
PQTVMLHEL (2)
TGWERNFAMMAYGDSWRRHRRLFHQHFRLQNVPAYHDQIAKGARNLAQLLLQTPDKFGRHIRHVVGAVILDIMYGIEVAPDDDERMEHLERAVHIFMELGQAGGFL
(1)
VDFIPA (1)
LKYLPTWFPGAAFKRQAMEWKPQVDAMYEISYNEVKDSMQRDQAKPCITSALLTACWDDLDQSNMEETLIGVTGTGYAGSDTSVFALNAFVLAMMLFPDVQRKAQEELDRVVGRERLPSADDRDSLPYISAVIKELLRWHPITPTAAPHKSIADDYYNGYFIPAGSIVIGNTWAMLHNEERYPDPEAFKPERFLTPEGTLDPHVPDPAEGFGFGRRICPGRHFAQASLFLNISNVLATCMIEKPVDEFGNVVEPTRECTSRFFWALKPFEAKITPRFEGVENLVQTMSTYTN
>CYP5144D4 Scaffold_252d seq next to CYP5144D5
e_gww2.1.429.1 [Phchr1:132914] CYP55% to
CYP5144D5
revised at HETVMARDL 8/16.2007, added C-term
Phanerochaete chrysosporium
MQSNALVIACLVAGLLAVARASRKSRQRRYPPGPNGLPILKNLFDIPRTYSWLTYEAWGREYNSDVV
HFEALGLHFVVLNSTEAAKELLEGRSHIYSDR (2)
HETVMARDL (2)
TGWHRHWGIMAYGDAWRQRRRLFHQHFRP
QAVPQYHEPMVRSARTLLQLLLESPDDWMRHVHHVSGGTVLKVLYAVDVDPHDDEGMDVVDKALQIFMKLPEPFV
(1)
VNFIPP (1)
LKHLPAWFPGAGFKRRAMEWKVHVDRMFEEPYHKIKVAAVTRPCIATSLLSAAWEDLEN
PDVEEQLISVLGTAY
GEYNLALEQTIFSVYSFVIAMMLYPDVQRKAQEELDQVVGRDRLPEIADRESLPY
FSAVLKEVFRWHPVTPIAAPHKSLEDDWYKGYFIPAGTIVFGNTWAILHEESRYAEPDVLRPERFLTPAG
TLDPAVPDPDEVFGYGRRICPGRYFVQDALFLYASHLLAAFTLSKFVDDEGHVEEP
(2)
RLTCIFVTLRIPRAFKANIKPRYEGAERLVQMAFTSAS*
>CYP5144D5 PFF_252c =
GX.24.18.1 revised at micro exon 8/15/2007
revised at HKTVMLHEL 8/16.2007, EST = DV762757.1
Phanerochaete chrysosporium
MSDSTLLAVGLIFGLLVLARVSRKRPRFPPGPKGLPIVGNLFGIPRDHSWLTYAEWGRLYISNIVHFEALGQHFFVLNDEKITKEIFEGRSQIYSDR
HKTVMLHEL
TGWHRNWAFTPYGESWRQNRRLFHQFFRAQAIPDYHDHMAKGARGLVQLLLQTPENWMRHIRHASGSTVLDAVYAMDVDPNDNERLEGVERAVETLVEIAEAGGYL
(1)
VDFIPA (1) LKHIPTWFPGAGFKRQAMAWKRDIDALFERPYHEVKSAMGCRIFSEQRGKARSCVTSSLMSMFSEKLGDPDVEETIMGIAGTSY
(1)
AGSDTTVFTMFAFVQAMLLYPNVQRKAQEELDRVVGRDRLPEVADRQSLPYVSAIVKEILRWNPILPAAVYHKSLADDWYEGYFIPAGSIVIGNTWAVLNDAERYPDPEPFKPERFLTADGQLDSQVPDPVEVFGYGRRVCAGRHFAQTALFLYIAHVLALFTIDNPLDESGHVIKPRRDCLTRLVPKPFKAKFKPRFTGVEELVHMSSIPTQ
>CYP5144E1 pc.8.2.1 (genewise.8.1.1) REVISED AT PRMPMLLDL 8/16/2007
fgenesh1_pg.C_scaffold_17000192
ADDED N-TERM AND COMPLETED C-TERM revised seq at EXXR
Phanerochaete chrysosporium
MGDTLALNGGIVLAVIVACSIALLLFQRRPHLP
LPPGPKRWPVVGNAFRFPKEREWLTFMRWSREFGALXDLLYYEMWGRPFVVINSHRAAVELFERKSALYADR (2)
PRMPMLLDL (2)
CGWAWDLAFMPYDETWKLARKLFTQHFRAGAAGRYRDEETRCARELLADILRDDTQLFEHARVTFGKLIMSVTYGIDVRSADDKYITNAQKALYAITATGNVGTYLVDSIPLLKYIPEWFPGAKFQREAREWREAAEAMSQRPVEDVKIAMAEGTARPSVLRSLLEDYGETMSAQEAYAILSATGTAYEAAASETTWSATLTVVLAMLLFPEIQERAHAELDRVVGMDRFPVFEDQPSLPYITAICKE (0)
ALRWRTPLPL (1)
AVMHRVTQDDVYNGCHIPGGATVVLNSWAILFDPDQYPNPEPFAPERFLAPSGELAPDVPEPTAAFGYGRRACAGTAMALDTLWIVVASLLWAFDIRRAVDEMGNEIDVAGEYTFGVVCYPAPFRCALRPRSEGIRSLISLPE*
>CYP5144F1 pc.240.2.1, e_gww2.5.175.1 [Phchr1:131322]
REVISED AT PEMPMLNDL AND MICRO EXON 8/16/2007 Phanerochaete chrysosporium
MVSAVLQGLAGLVIILLVRWAARQRQDRKQGPHPPGPPGLPLLGNLLDMPDNPSWMTYIRWSEKYNSDILRLNVLGSNIIIVNSLDAANDLLDKRSAIYSDR (2)
PEMPMLNDL (2)
CGFGWNVAFRRYDDTWRNGRRVFQHELGPQVVKRFRALEEHATHQLLRNLLREPAEFMGHLRHMSAFEILRIAYGIEVTGREDPYVDTAEHAVGAVVATCSPGSYLVNIMPFLKHIPEWVPGAKFKQDAKVWRRYVTELRDKPFSVVKERILRGDAPDCAAKSLLESLESGEDTAGYTEDDIKYALGSMYA (1)
GGSDT (0)
TVSALGSFILGTVLDPAIQARAHADLDRVCPGRLPTFDDQPELPYIDAIVKEALRWNPVLPIDVAHCSIADDVYRGYFIPKGSLVLANSWAILHDEAAYADPLRFHPDRFMAGDALDGRVREPDAAFGFGRRICPGRYMAYDAIWIAVACMLAVFRIDKAKDAQGREITPSGEYNVGFAYPKPFPCDIRPRSSAHEALIRATAEDA
>CYP5144G1 pc.119.17.1 , gww2.5.320.1 [Phchr1:40563] ver2
revised TVCSISYEL and I-helix region 8/16/2007 Phanerochaete chrysosporium
MSSLLRVADAVLLCAALTIIYKLCLRQAKPSRLPYPPGPPGYPLIGHLSGPEGPGGRSWVTFRDWSLQYGSDVIHLNMAGTHLIVLNTLGACSDLLEKRSTIYSDR (2)
TVCSISYEL (2)
CGLGWSFGLQRYGPEWRDGRKCFESQFNAHAVRKYRPALSREVSRFLHNLCTDPVAWEYHVHHMAGALIMSVGYAIDVQAKDDPYLNAAEHAGECVQKTLVPGAFLVDILPFLKYLPDWFPGVGFKQKARSWRKSIMYIRDAPYDVTKKRVVSAVVPDCVAKDLMEKMVNNAKDPVYMERVARSAVGSMYL (1)
AGADT (0)
THSVLSACVLTLVLNPNFLPRAQASIDEVCQGRLPDFSDYEALPHVHAIVREAMRWNPVVALNLPHRCTTDDIYEGHLIPAGSIVIANIWAILHDPAVYPDPESCNPMRYLRCSPDGTVTLDPAVPNPADVAFGFGRRICPGRFMGYQTVWLALARMLAAFDIQCATDADGVPIVPRGEYDRPKPFECSIKPRSAAHAALVMQDVDAGEL
>CYP5144H1 ug.119.22.1, gww2.5.193.1
REVISED AT FGFTMLREL, FGF END DOES NOT HAVE AN AG BOUNDARY
POSSIBLE FRAMESHIFT IN THIS REGION MIGHT CREATE PRLTMLREL
COMPARE TO LENTINULA EST EB011290.1 WITH PRMTMLNEL
REVISED MICRO EXON REGION AT I-HELIX
Phanerochaete chrysosporium
MASTSQTAFNAALGAACLVYLFAKIYWFVAAGRNLHGLKKLPGPRGWPFVGYLKAAERPAWLTYWRWSDEYDSDVVTFDVLGTTVVILNSLKAATELLEARSAIYSDR (2)
FGFTMLREL (2)
VGFDWNITVSEYGPYWRDSRRAFAHAFHPHAVARYRPAELKATHQFLRDLLNEPEDFHGRIRYLAGRQILHIAYGLEIRDRADPWITAAEHGVEIAVKCIIPGSYLVDLIPILKYVPEWFPGAGFKRQARIWKKEVTSIADAPLAAMEACDSLPDDSAAKPLLERMLDSPDDPAYARHVLRGTLASMYI (1)
AGADT (0)
TTSTLATFFHALSRHPAVLYEAQRAVDRVCAGRLPTFADYDALPYIHALLRECLRWRPVVPLNFAHRASKEDVYEGYRIPAGALVLANNWAIMHDPAAYTDPEDFNPRRFLRARAGAGANGSGADDSLELDPGVRDPGVAAFGFGRRACPGRYMAYESLWIVMASVLTVFDVLPAEGDEGEVEYTDGFLSTPKPFRCTIRPRSAAHAKLVYLALELDA
>CYP5144J1 genewise.24.21.1
= scaf252b = pc.24.20.1 = genewise2nd.24.19.1
46% to
CYP205b (CYP5144A2), revised at micro exons 8/16/2007 added N-term
Phanerochaete chrysosporium
MWVVTCTCAAILYMVLVGLRKRHRFPPGPKGLPLIGNVLNAPAGSSAP
MVYQQWSKLFGSNIIHLKIFGTHFFVLNDAKTASDLLEKRSANYSGR
(2)
SQTVMLFDL(2)
TGWDRDWGLLDYGDSWKKHRHVHHRYFHPKVLEAYHPRMEKGVQMLLQLLHRSPADFNAHLRF
2537737 MTGHIIISIVYGIETKSADHPYIGLAEEGVKAFSATAVPGRFL (1) 2537865
VDSLPF (1)
2538014 LKHIPAWFPGADFKRQAALWKKDVDAMYETPFNDIKAAI 2538130
RRGETNTSIVGAALAELEGQADTEEAENIIMNVAGTAYPTASDTTIITLEFFILAMLQHPEVQRRAQADLERVVGNARLPSIHDQALLPYITAIMHETLRWRPPFRTVSLPRKSLHDDEYEGYHIPAGSIMIANEWAILHDEARYPNPEEFDPSRFLNTDGSIDHTVPEPVEPFGHGRRLCPGRHFAMDVIWLTIANILHVYSIEKAVDQSGNVVEPSGKCIDGLLSAPEPFQAVFRPRSDAAIALLRSID
>CYP5144-un1 PFF_45b pseudogene Phanerochaete chrysosporium
PGPQGLPILRSLFHAPAQFQQLAFQDWGHRYIVLNCAQPASDLSDNRSTVYSDKGGWDRNMGPLAHSAYWREHRRLAPHHFKDHVR
FTTAATPGMYL (1)
VDSFPM (1)
LRHIPAWLPGAQFKRAAARWRSIVEEVFDSGNPEPCLAACLPTSHRDREDTLMLENVVINTSGTAYAAASGTTTTTLLAFILTTMLYPDVQKAVRQELDSVVGQGRLPEMADRNALSSIPALMKECLRWRPPLPLGVPHRSTAEDERGRRIQVPAGSTAIGNAWXXXXXXXXYSDPEAVKPWRFFDAAGFGYGRRVCPGRHCLLDFVWLATANVLVVCSIEEPFDGQWDTVEPSEQHTTGTIIFLAPFEAVFKXXXXAHVECVR
>CYP5145A1 ug.82.21.1 ESTs = DV765434.1, DV765432.1, DV759462.1, DV757969.1
Phanerochaete chrysosporium
MFYPPLVAVDVVFALLALYLIVRFLQKDRTLPFPPGPKPLPLIGNLLDMPSTYQWVTFADWHDRYGDISSVTVLGQRIVILNSLDAAVELLEKRSAIYSSRPYMRMAGEILLWARTLVLSTYPGELFRDIRRFLHRYIGSRGQLERVAPFYELIETSTQDFLQRTLADPVRFVEHIRKNAGAIILNMTYGYKVQEGYDPLVDLVDRAVDGFVAASTPGSYYVDIFPALQWIPSWFPGAGWKRRAEAWRADTQAMCDVPFEFAKQERLHGDNNSKNFVSDNLASMETAQQEHHLKMAAGSLYSGGADTTVSAITTFFLAMTLYPEVQKRAQEELDAVIGTDRLPTLDDRERLPYTRALVSEVLRWNPIGPLGVPHVSTEDDVYRGYFLPKGSMFIANIWCVPPSTYTYSEPLRFKPERYLGEQPEMDPRCAVFGFGRRICPGACLNLAEASIFAVSAMALAVFDISKAVEDGVEITPKVEYTTGTISHPQPFKCSIKPRSKKAEELIRG
>CYP5145A2 pc.82.61.1 (genewise2nd.82.23.1) revised near RYG 8/16/2007
Phanerochaete chrysosporium
MPSTHITALDIAVAIFALYIIRRLLQRGRTLPLPPGPRPLPLIGNLLDAPSAYHWETFAEWNTRYGDVSSITILGQRMVILNSLDAAIDLLEKKSSIYSDRPVMPMAGEILLWSQTLVLSPYPSDRFRDIRRYLHRYVGSRGQLERVAQTHQLIEDETRGFLQQTLRNPLQFIAHIRKTAGAIILNMGYGYQVKEGHDPLVDLVDRAVNGFVAASTPGSFLVDIIPALRWVPAWFPGAGWKRKALTWRADTRATCDVPFEFAKQEALRGSTSNNFVSANIQDIENAEQEYHLKMAAASLYSGGADTTVSAITTFFLAMTLYPEVQKRAQQELDAVLGAGRLPTLDDREQLPYTRALVSEVFRWNPIGPLGVPHVSTEDDEYRGYFLPKGSIFIANIWYILRDPHTYTEPLRFKPERFLGEQPEQDPRAAVFGFGRRICPGACNARVA
>CYP5145A3 pc.11.258.1 scaf5 partial seq NOT ON TREE
54% to
gx.82.23.1 (5145A2) Phanerochaete chrysosporium
MQACLLEVFAHFPPVMAVLLVVLLLILTLFVLVTRKSSRHYPPGPRPLPLLGNIHNAPAQRQWKTFAAWKSTYGDVISLTIFGQRIVVLNSLESAIDLLEKRSAVYSDRPRMVMVGELLGWAQQLVFAPYGEHFRNMRKILHKYLGARGQLDKIEPYHEIIEAATAKFLVRALRDDSDFHLEHNVHMTSGTINLRIGYGHNIAEGDDELVQMMDDALVGFNRAAVPGAFLVDIIPALKWVPTWCPGTSWKRQAQEWKDLFVRMTEGPYAMAQQQAERGGHDNIVSMSLSEDMSPEDHYDLKMAVGSLYGGGTDTTVAIILSFILAMTLHPEAQKKAQKEIDALTNGERLPVIRDREELPYVRALISEVLRWNPLVPLGVPHRAIADDVYRGYFIPEGSTIVVNMWQLAQDPEVYADPEVFKPERFLGPDSERDIRTFVFGFGRRICPGLNLAEASTFAICARILAVFEIGKVVEDGKRITPDFAFRDGAVRFV
>CYP5146A1 pc.59.8.1 , fgenesh1_pg.C_scaffold_1000663 [Phchr1:663]
Phchr1/scaffold_1:2066931-2069520 Phanerochaete
chrysosporium
MDPATVAVAVVCALAVMHVLTRRARTRLPYPPGPPEDPIIGHLRQMPNNDEAAEVWYRWAKQYGDVMSLNVLGKRLVILSSEEAATELLEKRSSKYADRPRFPIFERIGWKDMVLLMPYGPYHKTLRKMIQVPFEKDKAFQFRDIQERATSIMLHNFLADPKGIEHHTHCRYVVSIIVEIVFGHRILSEDDEHLKIADVFVKIQHEASQPSLLDVSPLFAKLPSWFPGAWFVKYIEDTKAILSHAIHHPVSIVQEQLASGIAKPSFVADELERLIKAGQLTPQNKYDVSIAAHMIFGGGTETTWNTLTTFIACMLLNPEAQRKAQEEIDKVVGHGRLPDFTDRDSLPYVECVVKETMRWHPVAPVAVPHKATEDDVYRGMYIPKGAIVIANARSITWDERRFHDPHAFKPERFLPRPLGAGEDFVQGAVYGWGRRICPGRHLAGDMVWIAIARVLAVFDIQKARDADGNAIEPNIEFTTAVHPKPFPCELRPRSEKAASLIKESYELHSID
>CYP5146A2 pc.59.23.1(gw.59.18.1)
gww2.1.504.1 [Phchr1:38849]
Phchr1/scaffold_1:2095089-2097090 adjacent to
5146A4
note by a typo this was called 5148A2, but it is really
5146A2
Phanerochaete chrysosporium
MGFLTALLLVFVLLCVALVRAVRRRRARPPYPPGPPADPLIGHIRIMPSTDNAHEVFHDWAQQYGDVMSLDVLGTRYVILNSAEAATDLLEKRNSKYADRPTFPMYERVGWKDTLVFLPYGPYFRKQRKMLQLPLEKERVTDFRHIEEQETCVMLYNILSDPDNTDAFVHRRYTTAVTMELAYGHRVVSNDDEYLKAADMVIDVLRSVTRPSLLDVSPIFEYLPAWFPGAWFVKCIKEIKPVVLREIQHPVSVVQQELMAGTAKPSFVSQQLEDLSRENGLSQEDLYTVSMVAHQIFGGSETGWHTIMTFIACMLTNPDVQRKGQEELDSVVGRGRLPDFTDRDSLPYIDCIVKETMRWQPVVPLSVPHKAMEDDEYRGMHIPKGATIIPNARGITWDERHFHEPRTYKPERFLPRPQGAGEVFPQGAVFGWGRRLCPGRYLADDVVWLAIARILAVFDIQKAVDADGNVVEPHIEFTTVLTSHPKPFPCSLRPRSEKAAELVRQAYDMHMANVAV
>CYP5146A3
pc.59.24.1(ug.59.33.1) gww2.1.413.1 [Phchr1:38101]
Phchr1/scaffold_1:2097942-2100000 Phanerochaete
chrysosporium
MGFLTALLLALVLLCAIWVRAVRRRRGRLPYPPGPPADPLIGHIRIMPSTDVAHEVFHGWAQQYGDVMSFSVLGTRYVILNSAEAATDLLEKRNSKYADRPTFPMYERVGWKDALVFLPYGSYFRKQRKMVQLPFEKEKVTDFRHIEEQESCVMLYNIFSDPDNRDAFVHRRYTTGVTMELTYGHRVVSDEDEYLKAADMIIDVLRSVTRPSLLDVSPLFEKLPAWFPGAWFVKCIKKTKPVVLREIQRPVSVVQQKLMAGTAKSSFVSQHLEELSREKGLSEEDLYTVSMAAHQVFGGTETAWHTIMTFIACMLTNPDVQRKGQEELDRVVGSGRLPDFTDRDSLPYVDCIVKETMRWQPVVPLSVPHRAMEDDEYRGMYIPKGATIIPNARGITWDERHFHEPRTFKPERFLPMPQGAGEVFPQSAVYGWGRRICPGRYFADDMVWLAVARILAVFDIRKAVDADGNVVEPRIEFATVLSHPKPFPCSLQPRSEKAAELIRQAYEMHMANVEA
>CYP5146A4
genewise.59.20.1 e_gww2.1.326.1 [Phchr1:133267]
Phchr1/scaffold_1:2102681-2104782 Phanerochaete
chrysosporium
MGPTAFVAILLCAVLLVQAVRRRRTPLPYPPGPPADPLIGHLRIMPDTSTAPEVWHSWSRKYGDVMSLSILGKRVVILNSEEAVTELFEKRGAKYADRPSYPLYERVGWKDALILLPYGTYYRKLRKMLQLPFEKDKAPNYRHIQEQEACVLLHNFLRDPSSVESPIHRRYTAAIIIEIAFGHRVLSDDDEHLKAADMFVEVQHGAGRPSLLDVSPIFEKLPSWFPGAWHVRYIKEKRPMILHAIQHPVSVIRQQLVDGTANPSFVSQQLNDLIREGGLTPENQYDLSIVAHMIFGGGSETTWNTLTTFIACMLMNPEVQRKGQEELDRVVGRGRLPDFTDRDSLPYIECVMKETMRWHPVAPLAMPRRAIEDDEYHGMYIPKGAMVIANISLTWDERRFHDARSFKPERFLPKPEGAGEVLPPSFAFGWGRRICPGRYLADDVVWIAVARILATLDIRKPKAADGSIIEPRIEFEAALTSHPKPFPCEIRPRSDKAAELIKQAYDMHMASVET
>CYP5146B1 pc.59.19.1 ,
e_gww2.1.427.1 [Phchr1:132579]
Phchr1/scaffold_1:2085390-2087317 Phanerochaete
chrysosporium
MLVLLGFVSLVLFLVYRRSVRASRGRLPPGPPADPIIGHMRVFPRANHGEVFHQWSKQYGDVLHLDVLGKSIIVLNSQEAANDLLDKRSANYSDRPEFPAFNLLGWDSMLVFLRYGPAFLRQRRLMQQPLTRTGVVVFRPVQLQQCHVLLKNLLASPKDFDAHLRRRFASAITLEMTYGHKVSSDDDAYLDIADKVNVVLTKMSKAAILDLFPRAKHLPSWFPGAWFIRYANDHRHLIWEMASKPFEQVEQQLAAGTAQPSFVSMHLEEMHRQNTHDADNVSALKTAAAHMWTGGEETSTLLIFVLAAVRNRDAVRRAQAELDRVLGPGRLPTFEDMDALPYVEAFIKETIRFHSALPLGIPHRAMADDVYRDMLIPKDATVLVNSTALARDPAAYSTPERFWPERFLPPHSEPPPVGLGFGWGRRVCPGRHLAEASLWIVVASMLAAFDIAPVQDAHGRDAPPELRFTQAITFSEDSHPEPFECSITPRSEKVAQLIMQL
>CYP5146C1 pc.175.6.1 (genewise2nd.175.5.1)
scaffold_6:685560-687500 region Phanerochaete
chrysosporium
MMPYILGVTLLLLTVIVLRVLRARASRAAPYPPGPPAYPVIGSVGPFPAHEPHLGLAELAKKYGDVMYFEIFGKPLVVLSSLEAASDLLEKRSAIYSSRPRFAVHEMIGWTDMVSFLPYGEQFNKQRKFFLHTFSKQGCLVFRSSQVAQTHLLLKNILQCPTRYIEYLRRFSTAVIMEIAYGHKVSSEDDPYVKIAEDTNNVLMAAGHSLALVDFLPWLRHLPAWFPGNWFARVAQESRPVIQRMRNFPFDQVVQQMASGTASPSFVSMQIEELERDGGASPENLHILKIAASQMYGAGAETTWSTIMNVIAFLLLHPTAQRKAQDELDSVLRGERMPDFDDRKSLPYLDALLLEVMRLQPTAPLGVPHSSTTDDIYRGMFIPKDSIVLTNTTYALAMDDRVYRNPTEFRPERFLPPHAEPNPNGIVFGWGRRICPGRYLADTSVWIVMASFLTVFEIVPERDRNGQDIIPEIQWCSAPFPCVIRPRSEKEVKLVSRL
>CYP5147A1 ug.50.27.1 Phanerochaete chrysosporium
MPLLLVDIAALVAGLVLLFMLDSWRRKGQHLPPGPPGLPFLGNILQIPRKKEFIVFRDLGNIYGDIVTLRVPGQIFVILNSRKAVADLLDARSQIYSDRPRTIMCKDLIGWDGSVVLSNNTPRFRDCRKLLRKGLGPSAVQSFIPFLNRQSAFYLENLQKRPEAFVDIFKRNAAAISMKIAYGYDGIQDDEELYGIGAMANHYFAETAVVGVWPVDMLPILRHVPQWFPFAYFKKYAAQAKPIVLESVNRPFEETKRHMKRGTAGGSFTSMLLEDAKGDPETEDCIKWSGTGIFLGQMDTTTSALSWFFLSMVLHPEVQAKAQAEIDKVVGNERLPRFEDKESLPYVSAVMQEVFRWHPVVPMIPHALSKDDEYRGYFIPAKTSLIGNIWAIMHDESLYPDAEDFRPERFTEDGAPDCLNVAFGFGRRVCPGILIAQAHVFVSIATTLATFNITKARDAQGNIIEPVVEDTPGAINFPQPFKVSLEPRSAAAADLIRRSAEHSKTLPERLEIFSLDA
>CYP5147A2 ug.50.57.1 this seq matches an unannotated region scaf 50 178-179kb
ug.50-57 is from the first 5 kb of this scaffold, about 170 kb away from this seq.
this matches my scaffold_15f. The ug # is wrong.
Phanerochaete chrysosporium
MLDVGATAAAGLLLVFLLGLGLMKTQHLPPGPRGLPLLGNVLQIPRRLPHVAFRDMGHKYGGDIVTLRVPGYNLLVLNSRQAIYDLLDSRSAVYSDRPQGTIYRKLLRKGLGASAVQSFIPFLNRQSALYLENLQSRPEAFVEITK
RNAAAISMKIAYGYDGIADDEELYRLAHQTTIYFAETAVLGAWPVDMFPILRFIPSWFPLAYFRRYAARARPVVVECINKPFEETKRHMRLGSAGASFTSMLLGDANGDPDTEDYIKWSSAAIFLGQMDTTTAVLSWFYLAMALHPEVQAKAQAEIDQVVGNERLPHIEDRDSLPYVCAVMREVFRWHPVANLVPHATDKDDHYRDYFVPAQTVAIANVWAVLHDEDVYHDADKFIPERFSEEGAPDSLEIAFGFGRRACPGKVVGQAHVFASIATVLATFNITKARDAQGN
VIEPEVMDTPGAVNTPQPFKVNIEPRSEAAVDLIRRSAEHSRTLPERLEIFSLDA
>CYP5147A3 pc.16.140.1 Phanerochaete chrysosporium
MLLFAAVSTVLALLLASVLTKARRKARNLPPGPKPLPFIGNAHQIPPENEWIKFKEWGDEYGDLVKIKIPGSMLYIVNKRKVVDELFEARSAVYCSRPNFIMASLSGWDHSIPTLPYGQRLRESRKLLKKGTSPAAVKTYHPYINRDLPFFLENMLSTPDKFVEHYNRNAARIALKIAYGYEGITEDERIIQGGVKAMEVFSATAVPGVWAVDTFPFLRHLPSWAPFSSFKGFAERCKRITDEALNTPFYEVKQRLEKGTADGSFTSVMLSTEKLDPETEEIIKWCATGIFTGQFDTTTATLSWFTMAMAKYPDVQEKAQAEIDRVVGRDRLPEVGDRDSLPYTWAILQETMRWHPTVALVPHTAIQDDTYGGYFVPAGTTVIANVWAMMHDENVYHDADKFMPERFYEEGAPDSLSVVFGFGRRICPGLVVAQTHMFVTIASILATLNISKARDNAGNVIEPREDAKSGVINFPKPFQVSITPRSDAAVQLIRRSVEHSKTLPDKLELFSP
>CYP5147A4 pc.16.141.1
Phanerochaete chrysosporium
IFTAVLAVTVVSLLTRRKNGRHVPPGPKPLPFIGNALQIPPQHEWIKFKEWYGPRLRESRKMLKKGMGPAAVKTYYPYINREVPFFLENMLRKPDSFVEHLKIAYGYEGVTEDEKIIRGGVDAMEVFSAVAAPGVWVVKYVPSWFPFAKFKKFAERGKKITDEALDTPFYEVKRRVTTATLSWFTLAMAKYPEVQKKAQAEIDRVIGKDRLPEVGDRDSLPYVWAIMQETFRWHPTITMSGYVPHTAIQDDEYRGYFIPSGTTLMANIWRERRSWPISGACPLRLMFEVIYHVHRGILHDEKLYHDADKFIPERFCDEGAPDSLSVAFGFGRRRRVCPGLVIAQTHVFVTMASMLATFNITKARDSTGAVIEPREDAKSGVIPKPFVVSITPRSDEAVTLIRRSV
>CYP5147B1 pc.50.95.1 Phanerochaete chrysosporium
MLLQVLAAIAALFVLSGLLNSRRRNMHVPPGPKALPLLGNVLDIPKKDVHVTFRDWANIYGKDLMKVEMPGETLYVISNKKVMVDLFEARSAIYSSKPTMTMADSSGFKNSIPLLPYNARLKTSRRLLKQGLSPAAVRSYFPYINNRTALFLEALLKDPDDFVRHFTRTAAHTALKIAYGYEGVTEDHHLLHTAIETMEIFATVVNPGRWLVDTLPILDRIPVSFPFANFKRVQEESRPVVFETVSKPFEEVKKHLAEGTADGSFSSYLLQSEKPDPETEDCIRWAATSIFLGQFDTTTATLSWFTHAMVKFPEVQKKAQEEIDRVIGNDRLPEIQDRDSLPYVNAIMKEIFRWQPIISMLPRSVVQDDEYNGYFVPAGTYLLANIWAVLHDPEVYPEPEKFMPERHLKEGVPNPLDVTFGFGRRVCPGMQVAQSQTFGTMAAMLATLHLKPQKDEHGRDIIPETRTVDGLIRFPVPFKCAFVPRSEAALKLIERGAEHARSVPDRLERWSD
>CYP5147C1 pc.50.96.1 Phanerochaete chrysosporium
MVQASDTLLSVVVCAALITLTSFLLSGYRKRNAHLPPGPKPLPIIGNLHQLPDLKADRAVAFRDMSLAYGSDILCVKVPGMLMYILNSKESMFDILVTRSAKSSSKPPQVMADEXLSGWKYTVPSLPYGQRIKTSRRLLHKGLGPSAVQSYIPYLERESAFFLEKLLDQQDAYKKHVTHTAARIALKIAYGYEGVTDDAHLIDTAVKAMNIFCVTATPGIWLVDSLPFLQHMPSWFPGTGFKKQASQWSQTVLYAINHPFEELKRQMAAGTAGASFAGRLLEVEDLSDPEVEDCIKHCSTGIFAGQFDTTTAVMSWFAVVMAFYPEIQKKAQDEINKVVGHERMPVVADRDSLPYVNAILKELLRWRPVLPLIAHSVNEEDEYKGYYVPKDTVILANVWAVLHDESNYDEPEKYKPERFLRDGILDPSVLDPATLAFGFGRRICPGMHIGQTLLFILMSRTLQNFDIAPAKDAHGREIAIDTSAVPGLIGFPKPFKVSLVPRSNAHATHIRHAAEHARSLPDKLAIFEL
>CYP5148A1 pc.79.37.1 Phanerochaete chrysosporium
RWAKTFGPLYSMWIGNQLFVVISDPQIVKDLVITNGAIFSSRKDMYVKSQIIFRGRGITTTPYGDTWRKHRRLASQFLGNRVVSGYLSGLEYEVQDMLCGLLTDGQAGFVPVSPQ
AYLGRLALNNIMTIVFGTRTGSIDDPFIHHWLTLSREFMNCTGPVSNWVDFVPFXCMAKFLLDVKDKERLDDLDIILLCCGFLVGGVESTAAIKQWFAAHISVLPEVQAQAQMELDRVVGRDRLPQAEDAKDLPYVRAIVKEIERVHNPFWLGTPHMSTEDFSYRGYKIPKDTAVILNTYTMHHDSQRYPNPEKFDPDRYIDDERSSAESAKLADPYQRDHWTFGAGRRICPAIALAEHEIFLSVAGLLWAFDMRQLSDAPIDLKEYDGLSGRSPVPFCIRLVPRHERVAAVVGASCHTATCRNG
>CYP5148A2
ug.50.57.1|whiterot1 not same as YadavÕs = pc.50.1.1 + pc.50.2.1 (This is the
correct ug number)
this whole seq not in Yadavs
collection
Note: a typo named another seq 5148A2, but
that seq was really 5146A2.
This is the correct 5148A2 seq Phanerochaete chrysosporium
TFVLLVAGILYIVLPFFFRKNLVDKNGNSIPPGPLLRLPYLPDYPERTLHAWAQKFGPLYSFFIGNQLYVVVSDANVARE
LLVNNGAIFSSRKQYFTKNQTILRGRAITASPYGETWRQHRKIAAQLLTPKAIQSYNNVLDYEARIMIRSMYKESMQGAV
PINPA
HYTGRYTLNNMLTISFAMRTESTQDPLIQRILAMAMEFNDLTGPFSNLVDFIE
PLQWLPTKTHARAAKLHDDFIEVYGSMVMAVKERMDAGENVPH
CLAKVLIEGQQQEKLDWEDVCMLSAAFALGGVHSVSGLRWFLALIGKHPDIQARAHHEL
DAVVGRDRWPMAEDEKDLPFIRAIIKEVLRVHAPFWNATPHSSTEDFVYNGMYIPKGAAVILNCFTLHHNEARYPDPYVF
PHCASYCLCANAMERDHWSFGAGRRICPGINVAERILFLAISRLLWAFTVH
>CYP5148B1 Aspergillus clavatus
47% to CYP5148A2
ACLA_082750
MSVMNDTDTLASVLPLDTISSSLGLAAVAKASSPSLWAITVLAGVTVFAWFRRTWTDAHGHKIPKGPRGLPIFGSFYSLT
RFPELTLDYWAKKFGDLYSIWLGNQLFVIVSDPHVAKDLMVTNGNVFSSRKEMFIKSQNVFAGRGITATPYNDRWRKHRR
IATTWLNQRAVDGYSPVLDRESMSLVKALFVESKGGLVPINPQ
(0)
PHAGRCSLNNMTTITFGFRT
DSIEHPLVKQALKLSREFMNCTGPMSNLVDFVP
LLQYLPTPMLRRGKKLHKGLVDTYGGFIKEAERKMLRGEKVTD
CLAKTMIELRHKEDLDDLDMAILASAFMIGGVETTAAIMQWFSALIPAYPEIQKKAQAELDRVVGRDRLPTIEDEKNLPYCHAI
VKEVERVHNPFWLGTPHVASEDFVYRGQYIPKDTVVVLNTWTMHYDPVRHANPEKFNPDRYIRDHLTSAESANLADPMER
DHWMFGAGRRICPGMIVAEREIWLTISRMLWAFDMHEIPGEPIDLK
EYDGLSGRSPVPFRIGLKPRHENVAKILESVEI*
>CYP5148B2P Aspergillus oryzae
even the stop codon and frameshift are conserved
RRGKKLHEDLVETYGGIIKDTEREMKEGKKVVLDCLAKTMVEMRDKEDLDDPDMAILASTFMIGGAET
(0)
TAAIMQWFSALIPVYPEIQN &
AQEELDLVVGRDHLPGIEDEQNLPYCHAIIKEVERVHNSFWL
GTPHVASEDCVYREKYIPKETVVVLNTWTMHYDPTRHSNPETFD
(0)
PDRYINDPLTSAESANVANPMERDHWMFGAG ()
RRICPGMLVAGREIWLSISRMLWAFD
MYEIPDEPIDLK*YDGLSGHSPMPFRIGLKPRHENVAKVLQGIEI*
>CYP5148B2P Aspergillus flavus
100% to CYP5148B2P Aspergillus oryzae
AFL2G_08556
RRGKKLHEDLVETYGGIIKDTEREMKEGKKVVLDCLAKT
MVEMRDKEDLDDPDMAILASTFMIGGAET (0)
TAAIMQWFSALIPVYPEIQN &
AQEELDLVVGRDHLPGIEDEQNLPYCHAIIKEVERVHNSFWLGTPHVASEDCV
YREKYIPKETVVVLNTWTMHYDPTRHSNPETFDPDRYINDPLTSAESANVANPMERDHWMFGAGRRICPGMLVAGREIWL
SISRMLWAFDMYEIPDEPIDLK*YDGLSGHSPMPFRIGLKPRHENVAKVLQGIEI*
>CYP5149A1 gx.62.25.1 MORE COMPLETE VERSION OF pc.62.64.1
Phanerochaete chrysosporium
SEAYLPPGPPALPFVGNLFQLPRKSVPRTFATMSQQYGPLYY
MRVINRHFVIVNDLDLARILFDKRGAIYSHRPRLPMAQEVVKRDTMLFMNYGPEFRKSRKLVSTFLNQRNASKYWPAQEIESLKFVLAVQRNPSDWLKLTRWTATSLVIRLLYGIEVQDKDDALVGLAEDFARLTTETTEPGRWLVDAFPILRHVPAWLPGAGFKRWAKRAKARMDEFATLPYVMAKDKIEKGDITPCWTAEKLLETTEPLTEQDEKEIRHTATSMYSGTNAMVATFILLMLHYPEVQKKAQEEIDSVTGGTWVPGMRDRERFPYINCLVKELFRFSPAVPLVPHSLHEDDVVEGYLIPKGSWVMANMWAFMHDEARYPDPETFTPERFEARPGVEPQDDPLDIVFGFGRRACPGYLLGVASVYLNIVHLLFAFDIAPVKDAAGASVLPPIEFSDGHVA
HAKPFECDMRERSAERIALIEHTA
>CYP5150A1
pc.24.95.1 red is new POSSIBLE GC
BOUNDARY AT ETMRL
scaffold_1 (3273479 bp) : 2653416:2656338
(2923 bp)
Phanerochaete chrysosporium
MAFSLPLISATVLLWVLWKVFRNYVVSSPLDNIPGPPRSSFWS (1)
GDSAIMYQRHGWSFHDNISEKYGPVSTTHTLLG (0)
ARGLYVYDQPKALNSIMITDQDSYEEPAWLLQ (2)
SSHAIFGPAVFIAQ (1)
GEQHRRQRRVLNPVFSGAHMRHMAPVFYDVAHR (0)
LRx (frameshift)
AVSAQIHDPASSEIDVLEWTSRAALELIGQGGLGCSLDPL
VADSNNDFGTALKTLI (2)
PLISGLHFYRMLMPYITPFVPLSVRRLFMRWVPHKNAQ
QLRAATEDLWALSRQIYEEKLAAVAKGDNDEVFEGQDLISIL (1)
IRSNTAAAAEDRLPEEEIIAQVA (2)
GLILAATDTTSSALARILHILAERQDIQDKVRAELVEAAGEGEDI
PYDQLVNLPWLDAICRETMRL (2)
HPPANIVNRE (2)
ARTDVIMPLSEPVQGRDGTLIHEIAVPKGTLVTISVRGCN
RNKAIWGEDALEWKPERWLKSLPETVSGAHIPGVYAH
(2)
MTFIGGARACL (2)
GFRFAQLEM (1)
KVVLAVMLRSFRFQLSDKEVYWNFAGVVFPSIGRDGKTASMPMKIETL*
>CYP5150A2 fgenesh1_pg.C_scaffold_2000178 [Phchr1:1200]
= gx.121.14.1 LOCATED ON VER 2 SCAFF 2, 527-529KB
58% TO GW.95.20.1, 53% TO PC.24.95.1, 51% TO PC.10.108.1
55% to 153.5, 49% to 66.11 Phanerochaete chrysosporium
MTSAPLLAFGAALIAIIWTLFQGYLVKSPLDNIPGPERSSFWLGNHGDIFNRHAWNFHDRARQLFGPVFR
FWGPFASRGLFVYDPKALNSIIVKDQLIYEESRWFISWNKYAFGLGLLSTLGEHHRKQRKLLNPVFSINH
MRHMAPIFYQTTHRLRTAITAELEASSADVDVLNWMGRLALELIGQGGLGYSFDTLVAHTHNEFGDAIKG
YVPAILNVIILRNIIYPYMDEYIPAKVRRFILDILPFRSVRRIQKIIDDMHSHSRRIFNEKKAALEKGDG
AVLHQVGEGKDIMSILLKANMEASDEDRLPEDELIGQMT (2)
TLVFAATDTTSNALSRILELLAKNQ
DVQDKMRTELIAASPDGEDIPYDTLVALPYMDAVCRETLRLHPPVNMMSRETREDVMMPLSEPIQGVNGE
TISEIFVPKDTSVIVSIRACNRNKAIWGEDADEWKPERWLSPLPEAVGNAHVPGVYSHLMTFLGGGRACM
(2)
GFKFSQLEM (1)
KVVLAVMLRTFKFFPGKNEIYWNMGGVNYPTAGKDSNKACMYLRLERIAS*
>CYP5150A3 pc.153.5.1 LOCATED ON VER 2 SCAFF 2
scaffold_2 (3043971 bp) : 1623404:1625693 (-) strand
(whole gene range)
57% to 95.20, 56% to 121.14, 51% to 10.108, 51% to 24.95,
47% to 66.11 Phanerochaete chrysosporium
MVPPSTFVLCALGGWVFWKLFRGYFTRSPLDNIPGPRRASLLK (1)
GNAHQLFNRHAWGFHERISQEYGQVVKFHAPFG (0)
GRGLYVFDPKALYHMIVKDIATFDEPRWFLQ (2)
MADFTFGPGLFSTS (1)
GQQHRKHRRVLNPVFSINHMRNLAPLFYTVAHRLRDGLSTQLTTSTGGE
VEILGWMGRAALELVGQGGFCHSFDQLDKNVPNAYRDVLKEVM (2)
PSQIALHFWRILLPYAVEYVPARIRRFLAPW
LPHPVMQKYRNICITMDEQARAI
YHAKKVALEQGDKLVEHQACEGRDILSVL (1)
VTANKQESVEDRLSEEEVIALIS (2)
TLAFFAATDTTSNAMARILHLLAEHQHVQDKMRLELFEAGM
DGEDIPYDRLVELPYLDAVCRETLRL (2)
YPPVLFMNRE (2)
TRQDAVLPLSKPIQGLDGDVLTEIMVPKGTLLMVSIVACNRNKALWGEDVLEWKPERWLSPLPESIREAHVPGVYSHL (2)
LTFLGGGRACM (2)
GSKFAQLEM (1)
KVLLCTLLRSYRFMPGTKGVYWNVGAISYPTPNEIDEKAAMYLTMDHIQAPQ*
>CYP5150A4 genewise.95.20.1 57% TO pc.153.5.1, 55% TO pc.10.108.1, 54% TO pc.24.95.1, 51% TO gx.66.11.1, 58% TO gx.121.14.1,
fgenesh1_pg.C_scaffold_2000729 [Phchr1:1751] =
gw.95.20.1
scaffold_2(3043971 bp):2185130:2187482 (2353
bp)
whole gene range Phanerochaete
chrysosporium
MATTTHGLALYALCGLCVWALWRVLRAYVVKSPLDNVPGPERTSFLK
(1)
GNTHQIFSRHGLDYLQELGERYGQVVRYYAPLG (0)
ARGLYVFDPKALNHIVVKDQAIYEEPRWFIR (2)
LNRLLFGPGLLSTL (1)
GDHHRKQRKLLNPVFSINHMRHMTPIFYNVVHD (0)
LRDAVAEQVKDTPT
EVNVLDWMLRTALELVGQGGLGYSFDALSAQKRNVYGEALKELL
(2)
PTVFALHFWRVLLPYVGAVVPAWVCRAAAPFLPHAAMQKLRRVV
GAMDAHSRRIYEMKKGLLEKGDAAVVHQVSEGRDILSIL (1)
MKANREVDEEDRLPEDEIIAQMS (2)
TLVFAATDTTSNALARIFQLLAEHPDVQDRLRAELT
DAAPDGADIPYDALVVLPYLDAVCRETLRL (2)
HPPASFMNRE (2)
ARADAVLPLAEPLRGADGAPITEIAVPRGTPLIIAIRASNRN
SALWGADALAWRPERWLAPLPDALAKAHVPGIYANL (2)
MTFLGGGRACM (2)
GFKFSQLEM (1)
KVVLAVMLRSFRFLPGDKEIYWNLAPVAYPTVG
KTSTKSELYLKLEPLKT*
>CYP5150A5 AADS01000067.1 = pc.10.108.1 54% TO pc.24.95.1
scaffold_8 (1906386 bp) : 331157:333480 (2324
bp)
whole gene range Phanerochaete
chrysosporium
MGPLQLVLVATAA
5407
WALWRLFRHYILRSPLDNIPGPASSSFIY (1) 5499
5550
GNLKEMFNRHGWGFHDTIIRQYGPIATVHSMLG (0) 5648
5713
ARALYVYDPKALNHIILKDQYTYDEPGWFLE (2) 5787
WHRMIFGPTLIATT (1)
5936
GAHHRKQRKLLNAIFSIARMRDTAPIFYNVAHR (0)
LRDAISADLN
6116
QGSGEINMIEWFSRAALELAGRGGVAYSFDALEANSENSEF
GMTVKQYR (2)
6345
PTTIALHFWRILSPYASLYIPRVVRLALGRLVPHKDLQ 6443
RIQMIAHAISAQSKKIYDFRMAAFQRGDEDAVREISEGRDVLSYI (1)
IRAGLNSEEERLPEEEILAHMS
6752
SGLILGATDTTSNALARTFQLLAEHQDVQDKMRAELA
DAAPDGEDIPYDQLVHLPLLDAVCRETLRL (2)
NPPIGLLARE (2)
7091 ARDDIVLPFLQPVHGRDGSLINEVPVPKGSTVFISVRACN
RNPLIWGEDAAEWKPERWLQPTPKSLSEARVPGVYANQ (2) 7312
7377
MTFLGGDRACL (2)
GFKFSQLEM (1)
KVVLAVLL 7556
7557
RSFRFLPCNKDVYWNLAGITYPTLGKDSDKLELPIKLEIIGGQY* 7676
>CYP5150B1 fgenesh1_pg.C_scaffold_2000954 [Phchr1:1976] = gx.66.11.1
LOCATED ON VER 2 SCAFF 2, 2927193
51% TO 95.20, 45% TO 24.95, 44% TO PC.10.108
49% to 121.14, 47% to 153.5 Phanerochaete
chrysosporium
MSLFALAIPWVACGLVLMLVYRLVRDYVVSSSLEDVQGPTPRSLIY
(1)
GNLPELQNRGAWPFLDHLTNDYDRVVRMRGMFG (0)
KRILWVADPKALHHIVVKDQDIYEEAPSAITF (2)
GRKLGMGPGLLSTL (1)
GDHHRRQRKLLNPVFSIAHLRRVTPVFYEVMNR (0)
LSKGIEKQLDTTSNNEVDLLAWMGRAALELIGQGGFG
HSFDPLVEQTPNPYADAVKSLV (2)
PAITGLIFYRMVIHLVDPLVEACAAHPALGAFIKRWFW
LVPNARMQHVKTIFDVLHDTSTAIYTEKKIALDSDDPELKMRVLEGRDLM
(1)
SVMLRENMNADAADRLPEREIIAQIT (2)
TFIFAGTDTTSNALARILHLLCLHPDVQEKLRAEIIEARAQNGGGDLDYDALVALPYLEAVCRETLRL
(2)
YAPVPFVSRQ (2)
ARSDALLPLSAPLTLRDGSRVSALHVPQGTSVLVAIHSVNRSAALWGADAHVWRPERW
LEKLPDAVAEARVPGVYSNL (2)
MTFIGGGRACM (2)
GFKFSQLEM (1)
EVVLATLLSSFRFSLCDGKNADIVWNRAGIAYPTVGNDGGHPSLPLRVERLKC*
>CYP5150C1 EB077269.1
Trametes versicolor cDNA clone
52% TO CYP5150A2, 50% TO CYP5150B1
SHVMAQVLQLLSEHPDAQAKVRREILEAGDGYIPYEKLHSLPYLDAICKETLRMYPPTPI
VLREAFRDTTLPLSQPMRGSDGSMLSHIPIPKGTNVLVGVRACNRNKALWGEDAEEWKPE
RWLAPLPKAVEDASIPGVYSNLMTFVGGGRSCVGFTFSQLEMKVVLSSLLANFTFQLSEK
PIFWHISAITFPSAAKDSLKPEMWLKVGRYTGEAA*
>CYP5151A1 pc.8.82.1
(name is not right pc.8.80.1 is correct (-) strand)
C-term is 37% to CYP5033A1 Ustilago maydis 30% overall
name error, CYP5144E1name assigned twice see pc.8.2.1
Phanerochaete chrysosporium cDNA clone
DV765344
MESFTLAALSLTTACAAALVAYLLYLCV
VYPLRNPIRQLPGPPSKWFLELRHMYMTMD
(2)
PRRSPHTAAEFVEKYGRNVYIRGPVPWDQRLFTLDPVTMNHVLQHT
AIYEKPWPSRRLISGLIGAGMLSAEGQMHKRQRR
VATPAFSLNEMRALIPLVFSKGT
ELQKKWMEIMRDAGVKPGQ
GHVVNVCSWA
SRATFDVMGSAGFDYEFNAIQNEDNELLRAYVDMF
ETAVSKQKAGLRSVLVMYLPIIDKIF (0)
159857 PNETTRFVSKCQTVIERVAGTLIQEKKRKMADAAVKGQVY 159738
159737 QGKDLLSLMRKY (1) 159702
159661 VKSNSAVDLPPDQRLS159572
DQDLLNNINTFMFAGTDTTSLALTWTLYVLALYPHVQDRLRAELLS
VAPIAPIDTLTPEE
VQSLYAEIAALPFLENVIRETLRLIPPVHSSIREATRDDVV
PVSAPLKRTTPNGRVVEEQVHQIVVPKGTFIHVPIEGFNLDKGL
WGETAWKFD (2)
PDRWDNLPETIKELPGLYQHTLTFSAGPR
(0)
ACIGMRMSVIELKSFLFTLVTNFKFAPDPTQKIGKANV (2)
ILTRPYVAGKQNEGSALPLIVTPYVREDAS*
>CYP5151A2 AACS01000049.1 Coprinopsis cinerea strain okayama7#130
WHOLE PREDICTED SEQ 55% TO PHANEROCHAETE
MNPILLSGLAAASTVLTWVVYRVVIEPRFNPLLKLAGPPSPGLF
GTNLAPVLSPTVSPRLHEVYAENYGRSMRIRGVGPWDERLLTLDPVSVAYVLKNSTIY
EKPWQSRALITSLIGCGMLAAEGQVHKRQRRVGTPAFSIQNLRGIVPLVFKKGTELKD
KWMEMIETTGEVRGSDEKEKSMVVDVCHWVSRATFDVIGVAGFDYQFNAIQNESNELF
NAYKEMFEIAISQGDGIITLISIYAPWIHKIFPNQVSRTVERCQEVIRRVAGQIIQEK
KRKIAEGEASGKPYQGRDLLSLLLKSNVAVDLPEDQRISDEDILNNVNTFMFAGSDTS
SLTLTWTLWLLANNPEIQDRLRAELLAAIPDTELTADISSLNEDEIQTLYGIIAELPL
LNNVTRESIRLIPPVHSSIRVATQDDEIPTRYPVKLADGTIDTKQSVKIAKGSFVHVA
VEGFNLDKEFWGADAWDFNPDRWDDQPETARQLPGLYNNTLTFSAGPR(0)
SCIGMRFSMIEIKTFLYILVTRFVFKPTKDKIIKSNVVLTRPYISGKYRE
GSQLPLIVTPYIPSAEH
>CYP5151B1 EB072414.1 TverSEQ10129 Trametes versicolor
pBluescript (EcoRI-XhoI) Trametes
versicolor cDNA clone TverSEQ10129, mRNA
sequence.
Length=897 45% to CYP5151A1
PNELNAAFQEVFNPGANFTIFTILKNVFPALDIFPDERAKRLDHAQDVMRRIGLQLIEEK
KAQIAREMSEGKSGGVERKDVQGRDLLTLLMKANMATDIPDNQRLSDEDVLAQVPTFLVA
GHETTSTATMWCLYALTQAPDVQKKLRDELFTLQTEAPTMDELSSLPYLDAVVRETLRIH
APVPTTMRVATKDDVIPVSEPFVDRRGKVQDSIHISKGSPIIIPVLSLNRSTELWGADAL
EFRPERWINPPETISSIPGVWGHILSFLAGPRACIGYRFSLVEMKALLFELVRAFEFE
>CYP5152A1 pc.24.121.1 65% TO pc.24.126.1, 42% TO CYP530A1 N. crassa NOTE: 5144C1 IS AT 2402616-2402515 REGION SCAF_1
5144A6 IS 2479233-2479132 REGION (-) STRAND SCAF_1
THIS SEQ IS AT 2699101-2698997 (-) STRAND SCAF_1
pc.24.126.1 IS AT 2713991-2713887 REGION (-) STRAND SCAF_1
same as model fgenesh1_pg.C_scaffold_1000845
[Phchr1:845]
N-term is in a seq gap possible frameshift
after FSFK
Phanerochaete chrysosporium
FKFAQLTEMYGPVFSFKQGTRVVCVVGRHQ (0)
AAVEIMQKH GADLADRPRSIAAGELLSGGKRTLLVGAGDRLRKLRK (2)
ALHSHLQPSVAVQYRPMQLKHALNVILDILRDPEHHIDHARR (2)
YAASVVMT
MTYGKTEPTYYTDPEVQEILLHGTRLGSVIPLDYHKVDRFPILKHVPFVTSTLRQWHKEELALFS
DLVDGARARL (0)
RDGAPPSFATYLIDQQQQFGLSDDEIAYLAGSMFGAGSDTSATAIAFVIMAAATHPKAQAEVQAQ
LDSVVGRDR (1)
VPSFDDESLLPLVTAFYLEAYRWRPVSYG (1)
GFAHKATADIRW (0)
GEYVIPADAIVIGNHWSIARDPDVFPEPEEFRPSRWLDESGKLREDLSSF
NFGFGRR (2)
VCVGQHVANN (2)
SLFINTALILWAFSVGEDPAQPIDTMAFTDTANVRVHPFKAVYEPRIPRLREVVETYLD*
>CYP5152A2 pc.24.126.1
35% to CYP5065A2 Phanerochaete chrysosporium
yellow IS AT 2713991-2713887 REGION (-) STRAND SCAF_1
possible GC boundary at PISWG
Same as model fgenesh1_pg.C_scaffold_1000848
[Phchr1:848]
MATGLLADVLARVQVPALALLFALLLLRAALRIVQRQRVPLPPGPPG
RWFEPGPKAPLRYAELAKTYGPVFAFRRGGQLVCIINSYK (0)
DAVEIMQKRGADLADRPDFIAAGDFLSGGMRTLLVGAGERVRRLRRC
RALHSQLQPTAAVQHKPVQFRAALDLVLDVLHDPADHLNHTKR (2)
FAASLILTMTYGKTTPTRYSDAEVREINVHTTRLGTVVPAGLHAVDRHPVLR
HVPPATATLRRWHREELALFTRMVDGVRKDV (0)
HVARPSFTTYLLEHQEEYGLSDDELAYLAGSMFGAGSDS (0)
TATAISFVMMAAATHPQAQAQVQAQLDSVVGRDR (1)
VPTFDDEKLLPLVVAFYLETFRWRPISWG (1)
GFAHRATSDIVWNDYVIPAGATVFGNHWAIGHDETVFSDPDVFRPSRW
LDEAGKLRDDISPFTYGFGRR (2)
VCVGQHVANN (2)
SLFINTALLLWAFNIREDPKVSIDTMGFTDSGTVRVLPFHV
QFHPRIEHLREIVESSMPEDVYSAA*
>CYP5152B1 Puccinia graminis f. sp. tritici
45% TO CYP5152A2
PGTG_14706
MMELIPATMRLIHNEIVQNFRIIFSLFICILSPVILSKITHRRRRLPLPPGPKSYPFIGYSFGPYHWRQMEKITKEYGPV
SSVRLGNNKLLVIVGRVEPALALLEGRSSIYCDRPQLEMAGNIMSGGLRTLCLPYGDRWKRFRR
(2)
VLHSQLDTKAATSF (0)
YQPIQERASRQLILDI
LERPKDFTEALTRYAASVIIKITYGKLTPIHHSDDEVVQVIKTLTRFSKAARIGAHAVDRFPWLRYIPGWVAQGRKWHQE
ELNLFSSQVDGVRREMNIPGKRDSCFASYMLERQKEFSLSDNEAAYLAGSLFGAGSDTTAVMVLAAALAIVIFAAACHPE
EVKKVQEELGSVVGNGRMPTFDDYFELPLVTAFVCETFRWRPASAAGFMHATVKDDVYEGHFIPAGSWVVGNHWSIHRDE
SVFPDPDKFDLMRWLTIDDKTGKTVLRQDMRHFAYGFGRRRCAGITIADRTFEDATNSRPKPFEVDFVPRVPDLRRAIEE
MSAC
>CYP5153A1 gx.27.66.1 = pc.27.122 Phanerochaete chrysosporium
fgenesh1_pg.C_scaffold_1000958
Phchr1/scaffold_1:3068242-3069378
32% TO CYP5116B1 Aspergillus nidulans
The unbroken reading frame starting with FNMYQ is preceded by a conserved non-p450 seq upstream that probably ends 460 bp before FNMYQ. The true P450 N-terminal must reside in between or this is a pseudogene missing the true N-terminal. The two short exons shown below are my best guess for the N-terminal, but they do not resemble other P450s, and the total length is only 443 aa, a little short, so the pseudogene alternative may be correct.
MVHDSGGAIFDTAGPALVR (1)
RTITVYPSDSLVQRGIQTNLELILKHIYTCEVSPIHPHLAPLHQ (0)
FNMYQTIVWYFTAVLFLLGAVVARARKRPVTSSLERIQLTDLRDIRELLAPISTSLPIL
LEQRSVPNARLVRAFGITNTFVSSSVDVHATFSREARALIAGNDWDRFAQCAQLAVDKCIEERTDAGTVMRYDTLMQNAALLSILMGLFEVALDDVPIADLGVVARGINDLWKLSKTADTLPPHMLPEINTRLRAWLPAHQNPVDLIIPAFETMWRVVATTVAYTHADPLAHAVLETFLADPTSTAFASARSGTPSVDALVTEAIRLHPPTSRISRHVVSNSTKGAVLVADVGALHRDPTIWGADAEVFNPLRHQQRTPTQEKALLGFGAGRVMCVASRWAPHAAGIIVA
SISERIGREIQVREGKAKGGRDWDGWFVECI*
>CYP5154A1 PFF_258a (gx. 18.4.1) 63% TO PFF_258b b (gx. 18.4.1), C-term 38% to 5141A4
Scaf_6 ver2 (-) strand
503798-505808 Phanerochaete chrysosporium
505808 MQDLGYLPGLRSLVTPMSPLGFALPPSQYNPGRDWQW 505728
505655 VYRDAGTETISAIPYVFGPP (1) 505596
LAKQVVSTKGQ (2)
505458 ILRLLCSLWGPNIFAANGEEWRKHRRIINPAFSNAT (2) 505363
FASVWEQTSRVFDEMEVGEGWAGKHTVNLPVVNGLTNK (0)
505139 LALILISTCGFGNPLKWQFTNSASGGMSFEKALSIVSSNHI
ALLLIPDWMYRLPNK (2) 504972
IRELKTAVDRMNLFMRELIEKRRAEMAQKAPERTDILSAMIK (2)
504735 LSWLSRFDNDCDKVGNTFLLLSAGH (1) 504661
504611 DTVAHTLDAAFALLALHQDFQEEVYQELLEVMPTEADFV 504494
504443 TYENSARLVKTRACFLEASRMFRI (2) 504372
SGFMLIRDTAEDVVLQNVGPNNDDVLPLKRGTRVVVDMIGL (1)
504143 HHNPRIFPDPEAFKPERWYNAHENDMSMFSFGARA (1) 504042
503989 CIGRKFAVAEGICFLAKLLRRWRVEPLAKEGETKEQWKQRVV
RGVVVLNLGIGEVPVRLVRRNC* 503798
>CYP5154A2P
PFF_258b (gx. 18.4.1) Phanerochaete chrysosporium
This one is looking like a pseudogene, no EXXR motif,
No N-term Met
Scaf_6 ver2 (+) strand 509278-511252
62% to PFF_258a in overlapping regions
509278 YLPGIRSLVSPMSALGASIPTSRWNPGRHWQW 509373
509448 VYRDAGTETIAAVPYLFGPPII 509513
509662 GPNIFAANGGEWKKHRRVINPAFSQET 509742
509963 LALILISTCGFSNPLSWQ 510016
510040 MPFADALWIVSTRIIARLLLPRWVYWLP 510123
510371 DYNMHQLGDTFLLLTAGHGT 510430
510478 MLALHPDFQEECYREILKVMHTNDDFV 510558
510606 TFGNSTHLIKTRSCFLEASSLYRM 510686
510727 AAGEILVQDVAEDTILRGAAPDGGDPPVPRETPIVVDMLGLR 510852
510906 DHNPKLYSDPEKFLPERWYNTHENDRTMFSIGAQA (1)
511010
511067 CLGRHFALVEGTCFLARLLRIWRVVPLLRPG
ETVEQWRAKIGVEALFNFGIGNVPLKFVRR* 511252
>CYP5155A1 fgenesh1_pg.C_scaffold_7000377 [Phchr1:4564]
Same gene as pc.81.7.1
whole seq is 40% to CYP5150A4
REMOVED POSSIBLE SHORT INTRON SEQ
VKAAKNKYLEDGRSTASTWE
Phanerochaete chrysosporium
MAVGLPEVVLAAIFAYLLYRETWGKKTALSDVAGPPRESWMK (1)
GNTQRLFRDALDYNLWLSRTYGTAVKMYSLY (1)
ALYLSDPLALHHVFVKDQNSFDVSDAFIH (2)
NLLMFGEGLTGTL (1)
GEQHKKQRKMLNPVFSVSNLRELLPVIQPIANKMASVFVEQIPAD
(1)
AREIDVMPWLSRGAQEYMSQACFGWTFNALDLNKRNTYSEAARKYT
(2)
PAALRVSWLRPYLPFIVRTIPLTLRTKMLDWYPGSDMKDFLYILDVM
HQTSKRIFEQKKKALDSTVLEKADAETSERSEGDLGP (0)
GKDIMSILLK
ANASSNEADRMTDSEMIGQMSTLLFAGFETTTYAISRILWVLASHPDAQARIRSE
(0)
DVSLSYDDLMALPYLDAVIKETLRVYPPSSVHFRVALQNTTLPLQYPVKSVNDTPITTIPVEKGT
QILVSIIASNHNTNVWGPDASEWKPERWLNSDDKAVPKATTDSAKYPGVYSGMMTFLGGPRGCIGFKFSE
MEAKQVLATLLPRLHFALPSAVDEQGRRKEVYWMMSGPQIPVVRPPFGDGMTAQVPLDVRLVREEDFAYG
FEDEDLIKL*
>CYP5156A1 gx.17.28.1
Phanerochaete chrysosporium
34% TO CYP602B1 Fusarium graminearum
scaffold_7 (2051558 bp) : 939436:940306 region
SAME AS
fgenesh1_pg.C_scaffold_7000309 [Phchr1:4496]
N-TERM in model SEEMS TOO LONG. Remove it.
29% o 609A1
MYPLGLLTIVQHFETRDAALKLAIALPSIVLLALLFSWVSARKDQD
EGPPFLPLSIWETVWPFFTSRHDFLRRGFELTRHPAFRFKLLQ
(0)
HTVVVVSQEHARADFFACRGLDIHEGFKVLSGA (0)
IPMLPGVTSDLQTRRINLIHRRLAAAQGGDHLQR (1)
LVPFIVQDIRQGFCSWGSTESLIDPFTRIPA (0)
LLFQTTVRCLGSHELADDGATVARLLSLYDTLDRSTTPLSVLLPWLP
SPSMLAKLRASKQVYDIVDGAIRARVASGVSRDDTLQILLDHGDEKMVIVG
(0)
FIMGLLVAGARSTGTT (1)
ASWIVTFLAGHPEWRRKVREEIHALLSLYAATTAHCANDPAELLATVPLEAFEQCMP
ATDAVIRETLRIAQPHTAMRRNVGPDTYIAGTRIPSGAYVVYPFSDIHLDPRLYPD
PWRFDPSRPESKSNIGYVGWGG (1)
GRTVCLGQRIAKLQIKLVLSMFLLHYDFDLVDQDEHPLGNVPR
PNWNDHLTCKPPSGSCLVRLAKQ*
>CYP5156A2 EB008493.1, EB007318.1 Gloeophyllum trabeum ESTs 61% TO CYP5156A1
LADIPLSAWEGSTPVLDAVIRETLRLAQPHTAMRRNVGPDLVIDGKTVPSGAYVVY
PFSDVHLDADIYPDPWRFDPGRPADAKRAHAWVGWGGGKTVCLGQRLAKLEMKIIA
AMFLVGFDYAVVDKAGKPADPLPKPNWNDALMCRPEAGSCYVK
YERAASSTSSSSSSSPSSPSSPL*
>CYP5156B1 EB016637.1 Lentinula edodes
50% to CYP5156A1 N-TERM ONLY
MPYSVGLQAAGAALLSAGLPVLFTTAIIVLLLIISINSSLQKDVADAPARLPI
YSFFTIIPFFRRRFDFLNWGFQATGQSTFQFDLLRNKVIVVSGESARQAFFTAKGLDLTE
GFKILSGAIPMVRGVTSDLQTKRISLIHKRLAAVQKNEQLSMLIRPMLEDSRRLMESWGN
SGCFDPFDNIYELVFQLTVRSLSCTEISDDPCLVSRLKKLYDTLDVGTTPATVLLPWLPT
PAMVKKLWATKEIYDIVVAAITAR
>CYP5156C1 Aspergillus niger
fgenesh1_pg.C_scaffold_15000299|Aspni1
34% to CYP4F11 aa 375-490 52% to 5156A2 frameshift after
TTNY
M P L A
S T V
I Y V
A I I
T S I
V V V
L F H
R V
F K P
Q N N
K K P
ATRSQNTLPPELRWSVAQLAHSFFTAQFDFIKEGFRVTGSKAFRFQLRKNQVIVVSGDEA
RRTFFGAKSLNLYEGFQVLIGT (0)
I P
T G L
N P R
V L H
G I Y
K R L
N N L
Q
R P
D N L
Q N (1)
S Y
I A P
V L P
Q L I
T D C
H Q K
M N S
W D
N L I
I D P
C S S
L H D
(0)
VTFQMIIRAVTSYEVAEDTRLVSRLKYFYDIIDASVKPLHLWAWVPGLATFYKLRASMYVY
WTFHQAVKRRVHSGVRRDDSLQQLLDSGESFQCIVG
FMMGLPIAGARSTGT
SGTWLLLYLASEPSWSRAVHNEIKDLTTNY
XXXXXXXXXXXXXXXX
AIPLAAWESQTPQLDLCIRETLRRAQPHTAVRRNIGPDLPIGAYTIPSNAFVLYPFSDAALNPTLY
PDPLRWDPGRTVVDNNAFIGWGGGTHLCKGQRLANLTLKIIVAYTLMSYKIDFVSKNGDVVTGVPVPDWNDYLTCRPQGD
CTLRFTKCRE*
>CYP5157A1
genewise.21.71.1 Phanerochaete chrysosporium
scaffold_9 (1898532 bp) : 1276291:1276784 (494
bp)
fgenesh1_pg.C_scaffold_9000353 [Phchr1:5749]
Phchr1/scaffold_9:1276084-1278363
30% to 608A1 Magnaporthe grisea over 412 aa
MSLLPPLTNLASGHISFFLGIPRGELFLLFLPFVVLIAFVLFKRIIQATKRKHASTRPL
CVLVSTDRPIDQLPPYHYRPTSKRFATMDLLSALRGREREYTKYVFADDKSLSFEEGAA
TILNLRFLLKIRGGRFYKDVDKLITSGIIPRIEAITNKIYPIFMRHARRLVEDGQKNNG
CVDFFAHTNHSIAESMLTVVMGEVGIYENLSWFSRTFPRLSKFSRLRDGLSDNGCPRLR
LLFGTLIYRYFFVLGPYVWRELRNNKFEPLARSEKEHDANESVLRYLGRMFAREDGTVS
AVDTCWCMCLMLSLIFASVHQTAVVAVWVMYELASRPTYIPAIREELLAVAELQADGSH
YLSYDSLRNARLLDSFIREVMRLKGDTLGVCRQTVQDTPMGQYVIPKGHLVIPMASLSH
RSREYHGQDAEVFDGFRWVERNLPAVMVGPTYFPFGMNRWACPGRVLAVSEMKMIALTI
LALADPTLEGGKYTVVDPLNTTSVQPAGKLYLTPLARPLI*
>CYP5158A1 39% to 5037B2, 36% to 5037B3, 36% to 5144A5
scaffold_2 2356566-2358785 Phanerochaete
chrysosporium
2356566
MLTSQVSIAKLTTLPTSYYA
2356626
LLATIALLALLFARRTQQPTPPGPRGLPIIGNVAELSGGFEWIRFGTTLRKQF (1) 2356784
GDVLGFKVLNNRILVLNTAKAAKEFMDKRASKYSSRPVLTVIGELMGLDQ (0)
AMPLIPYGAEWRACRKLEHVALNQSAVKQYRPVIEHHAAQLALDILQEPDKFLTHTRL (2)
IILAVTYGLSARVTATE (0)
YISLAEEVMRIVTIYLRPFAHLCDVMPV (1)
LKHLPSWIPFRREAEYGRRLFESFVSTPYERTKQAF (0)
AKGDAEPSLIRDILASMPQDSLTPEVEHRVKWTAGFALLA (1)
SGGES (0)
2357970
TFGTIGVFMMAMALHPDKQARAQEEVDSAVGTDRLPTMDDKARLPYVYAVVQEA 2358131
2358132 MRWHPMLPL
(1) 2358158
2358208
SLPRRAEVDDEYDGYYIAKDTTVCANLW (2) 2358291
2358346
AMGMEPNVKYPPEQFIPERFLDAEHPTPNPNTWAFGFGRR (2) 2358465
ICPGKALAEESLFVLMSTLLAMFEICAPPEGIKPEFESRVVR (2)
2358702
LPKPFKCIFRLRSPEKADMLRAVVATQ* 2358785
>CYP5158A2P gx.89.1.1
pseudogene Phanerochaete chrysosporium
92% to CYP5158A1
scaffold_2
2396927-2398113
2396927
MLTSQVLIAKLTALPTSCYA
2396987
LLATAALLALLSARRTQQPTPPGPCELPIIGNVAELSGGFEWTRFGTTLRKQF (1) 2397145
GDVLGF
large deletion here, missing 6 exons
SGGES (0)
2397300
TFGTIGVFMMAMALHPDKQARAQEEIDSAVGTDRLPTMDDKARLPYVYAVVQEA 2397461
2397462 MRWHPMLPL
2397488
2397541 LPRRAEVDDEYDGYHIAKDTTVCANLWY
2397624
2397685
MEPNVKYPPEQFIPERFLDAEHPTPNPNTWAFGFGRR 2397795
2397854
ICPGKALAEESLLVLMSTLLAMFEICAPPEGIKPEFESRVVR 2397979
2398033
LPKSFKCIFRLRSPEKADPPRAIAAAQ 2398113
>CYP5159A1 Coprinopsis cinerea strain
okayama7#130,
ACCESSION AACS01000290 REGION: 167200..168432
Yellow region not in pc model. look for it
39% TO CYP5153A1
MLDWQSTSIVIAAFLLASLLCLIAISLNQESAVGHSSLGGIRQL
FSPDGADVGTLLADRARPNQRLVRAFGITNTFVSPHPSVHRSFVTAARSLLSRANKRG
WGTFRDISTQAIHVELSLARSGSVNYGIFIQAVTLRVILVGLLGANVPMEDFSPDDIY
TAASHINKLWSLSKDPSPIPSHLLPELNDALRRLLPDITTFPNPVDIVIPAWETFWRV
VATTVAYSHNSKAITQLFLDFYAYPTDNAFREANADANISPKNVVEESMRLQPPSKHI
ARKTIRPSLSKLPKPIANLLVRFLPRISWVKHYADVQAVLRSPAIWGSNSLEFNPWRH
NQDPSSTLPSRAEALGYIFGGGNLRCIGSSWAPVAAAVVASAVFDAVDRGVCSIVPGR
AVGGRNGWEDWSVTDTKN
>CYP5167A1 Aspergillus niger
fgenesh1_pg.C_scaffold_3000005|Aspni1
38% to CYP5068B1
MTLSALIFVLCMGIATWLLVSYYGKRQRLPPGPAKIPILGNIHQMSQGNRFKLYEQFHERHGPIISLQIGMADMIVLGSH
RVAQRLLGDKGARYSSRPRAVMADDLATKGMNMVLMPYGAKWQTHNRATVSLLNSRAVGCYEPVFDLQSRQLMCELLATN
DFSPRLRRYIDALVLTLAYGKWVREEDEIRLEVDRIIDVATETLTVGISWIDQFPALLYLPRLVSPWKKTGDHIHRITQK
VFDQLWKAGLESPSWNWSKKLHQACSSSSGTQSAGLYLAPEEQSYLMGVLLEGGTETSTTTLRNFFLAILIRPECAVRAQ
QELDAVVGSARMPELGDMEKLPYLNAMILEVLRWSPPTYTAQPHAGSEDGEIDGYYIPSQTPLLMNFRAMTLDKEYYSDP
RKFLPERWPQQGKNNATKLPLPVFGYGRRACAGRLFALRGIYFAVSRLLWAFNVKPAPHLTADGLQFLVDNYVDHGATQE
PPPFEVVIEPRSSQRRQHLEQAWKNTEAMDLDEILDEIGSKVDKL*
>CYP5168A1 Aspergillus niger
gw1.13.785.1|Aspni1
36% to CYP670A1, 38% to gw1.4.1072.1, AM270073.1, REVISED 2/10/2009
MIHLVSFLYLIVNVPTSWQIISGYLL
YLVGLFSSILSYRLFFHRLNGFPGPRWASVSKIWHLWKTRRSQNHFFMAKLHAQYGDFVRTGPSEITVFHPDVFMAVDGP
RSKCMKGEWYDLLHPDRSLVNARTSDIHRPRRRVWMQGFTSKALVGKEEQTLGLIEQMDQCIQDDMAAGRSSNVTDMIYW
LSFDRMAQFVLGKKFNMLTNPDWRFAIRTVQKALSILGPLSPAPWLVQIVLRLLPRVWILKDWFRTMAMTKGELRNVPTD
MSKATSLGAFLMESSQKDSTQDQWLGGDSLLAFVAGSDPTAGILHGLFYELARHPEQADLIYRELQQLQPEELSDVNAVR
RCKHLEAAIFESLRLYPSLPTGGNRKTPANEGITVAGVYIPPDTTVVAPRFCISRREDCYVKPNEFIPERWTTRPELVLN
RSAFVPFGTAFRSCLGRGLAMNDMMLIGAHMIQHYRMSFPAGDTGDRVFNDWKDQFTSCLGRLELRFERRTA* 41791
>CYP5168A2 Aspergillus clavatus
54% to CYP5168A1
ACLA_060130,
MSPLAYILFGGTIGLGMHHGLFIHGEWHIQAPLIVLYHFTCFSVLLMTISHAEWLIGGYLLSLYTSIAVYRLFYHRLNSF
SGPVLARTTKLWHVWKARHRQNHLVLLDLYQRYGEVVRTGPSEVTVFHPDVFMAIDGPTNKCVKSEWYDLLHPDRALVTV
RVKEVHSARRRQWNRGFSSKALDQYSERILAFIDQLDHCIEKDIAAGRVSEATDLFYWLGFDRMGDFIFSRTFDMLSRQA
WHHIILLLQRALSILGPLSPVPWLIHIAFKLFPRVWVLRDWFNMMTWCEAQMRKRMQVMPDDPTKVPDVAHYLIQDANDS
PQDKGWLTGDSILAIVAGSEPTAAVLVGVFTELARHPQHAETIRREMQQLDIRDARALAQHCPHLDAVIFEALRLYPALP
TGGNRKTLQEGTTIGGTFIPPETTIVAPRFVISRREDCFEQADQFIPERWTTRPEMVRNRAAFAPFGTGHHSCLGRALAM
NDMRLVTARLVQKYNFRFPPGDKGEAVLRDLRDQFTSNPGRLRLIFEVRKKRNPSDSD*
>CYP5169A1 Aspergillus niger
e_gw1.18.102.1|Aspni1
37% to 630B11
MYKEIIVLVYILIVLRVVLAPIYTYLRDPKGLKRFPGVSVAPITDLWGVLQQYLRTRTLAVHKAHRKYGSIVRVGPTNIS
FSTPEAIRDIYGHGTPALKDDFYQTFNSTHLNVSDAQDRDVHSIKRKRFAIAFSQKRIVELEPVVQDHLQRVFHILDSAN
GKEVDMKQIMMHLMYNLIFIHHLLSSTLHISTSLGWAPRIRSLLKHLTCCHSGWKHGTQLQHITTHFVRERVNMDIERRP
LCLELGELVTEAQNLFSAAGGNTEIALTSIIWYLAGNPHIVRRLRAELADAILPQTDPSALISYDLVKNLPYLRACIDEG
LRLRPSIRGGLPRVVPKGGMMVSGEWLDEGITVSVSTYTVHRDPDIFGADPERYIPERWLQPDARDMQRGFLAFSQGGRG
CLGRNIAYFQMQLVIAALVWRYDFALREEGWELEVMETFSAHTVSLPVVATRRE*
>CYP5170A1v1 Aspergillus niger
estExt_GeneWisePlus.C_30253|Aspni1 revised
40% to CYP5102A1 aa 98-492
MGVGAVAVLLLAVLTVLRALRNYSRLCAIPGPSVAGWSDFWRICVRNKSHYGRRLSSLHRIYGTVVRLGPRFLSVADGTII
GHLDHGVDGG (0)
SPELQHRNTVPLNSVTISSDTLQTTHPTWERSQGIPE
YEGVIDPSTKQLIKAIRRYRVLDITSSLRIFAMTFINQLTADGLLQEKHNNSTGSGSRWLGVFSTVEYMLIRS
PVTALKRDRGRRLATCATLPVAATTVSVGENGAGSSTGTSPSQQRPCDGSRMKPSPNALRGAHGAAATFISLFYFLLRHQ
DYLDRLRFEIDTSFGIGSLSDIPRWRELNRLSYLDAVLKETMRLSVDFEEEIKAAVDGVTVAGFSVRKNTTLTWNSHVLH
FDSETFGNDVHSFRPERWLMADTQQRSRMEQGLISFNRCVRDHPEAQVVWMELKKVVVLILMKFNVSCTREILPAHH*
>CYP5170A1v2 Aspergillus
niger CBS 513.88
93% to estExt_GeneWisePlus.C_30253 (allele)
MGVGAVAVLLLAVLTVLRALRNYSRLRAIPGPSVAGWSDFWRIC VRNKSHYGRRLSSLHRIYGTVVRLGPRFLSVADGTIIGHLDHGVDGGSPELQHRNTIP
LNSVTISSDTLQTTHPTWERSQGIPEYEGVIDPSTKQLIKAIRRYRVLDITSSLRIFA
TTFINQLTADGLLQERHNNWKGSGSRWLSVFSTVEYMLIRSPVTALKRDRGRRLATCA
TLPVAAPTVSVGENGAGSSTGTLPSQQRQCDGSRTRPSPNAVRGAHGAAATFVSLFYF
LLRHQDSLDRLRFEIDTSFGIGSLSDIPRWRELNRLSYLDAVLKETMRLSVDFEEEIK
AAVDGVTVAEFSVRKNTILTWNSHVLHFDNETFGNDVHSFRPERWLMADAQQRSRMEQ
GLISFNRCVRDHPEAQVVWMELKKVVVLILMKFNTQLLHAAEPSIDAEDNFTPPSLMV
GFTPRVPGF
>CYP5171A1 Aspergillus
niger
fgenesh1_pg.C_scaffold_4000449|Aspni1
37% to CYP590A1
MAEISLRTALTILVGIYLLYKLLSFVRFYIIGRRSGYPLVVTPLFTQHTLWQIVGPTFQVQLKRYLPTWLHEHVDIHIHG
WEFRHKNAMHRRYGKVFAIVSPDECSLWIADPTVGATVLQRRKDFIQPDVVAKFMGVFGPTLIQSNGEDWTRQRRIIAPQ
LNETIMGEVWEESCRQARAMLEHLLQHPGG
X
DTLTGLRSIAINVLGQAGYGQNQTWSPDFVEALGEDWQGPRVSYFKTIAM
VTDRFVEAVLIPNSLKMLPCMPQSLRQLGRQMGKVPEYIKEILNEERNTKSS
EVSKTRHNLLDMLVRFADRGEEDS
XXXXXXXXXX
SKLS
LSEAEISGNLWVFTAAGF
DTTANTMGYAVMFLAQYPQWQDWMREELSQLDANTSSWGYETFSQCPRVLAVMFETLRLFTP
VLHSTRCVAATQQIADSDGTHVLTPPMNVFVSQQSIHRDPNIWGSDVDEFRPTRWLDDAGQVVTPAKGTFIPWSAGPRIC
PGMKMSEVEFVGAMATLFRHARCEPMQKGKLLQQMDDSISKLTLQVRELREVQLRWVPA*
>CYP5171A2P Coccidioides immitis
pseudogene fragment (C-term)
54% to CYP5171A1
CIMG_10420.2
VLEPQQLNNSTTGTQHLLTPP
MDIYVSQLSIHLDPAHWGPNAAEFNPSRWIDTSSSSDQIITPAKGTYVSWSGGPQICPGVKMSQVEFVATMATLFRSARC
EPLPTVGIEDAEMLRERLRQLAWDSVSKLTLQMRDPGRVQLRWVPMED*
>CYP5171B1 Histoplasma capsulatum G217B
47% to CYP5171A1
HCB06783.1
MVFTVFSVGITLSLSFFIYKLVSFVRHYIQARRSGLPIFISPVLSKSIPW
MVLGPYLQPFFQKHLPALLYDRLDIVTHGWEYRRGREFHERLGNIFALVTPDECLIWVADPAVGASILQRRNDFPQAPIV
AKILGLYGPNVFSANGDEXMFAANLDERISKTVWTESCRHASEMIKYMLKNPGNKTLDGLRSIAINVIGQAGFSQSGVWA
PTMRNRTGKATTGKAAFWETFSLTTEMLLEGAFLPTKVMRLPFMPPTLRLMGYHMERAPIYIKEVLDEERKAVENATGRR
NNFLSFLLKLSDEEKNSGDNGFSLTDDEISGNLFVFSTAGFETTSNTMGYAVAHLAVYPELQDWIREELRTLDPDPSKWK
YEEVFPKCRRTLALMFEILRFFPPVLHSNRSVFKPQQIVDGNKTRLLTPPMDILICQLSMHLDPTIWGADASEFRPSRWI
DESGQLITPPKGAYIPWSSGPRICPGIKMSQVEFVATLTTLFRSARCDPLPTAGIEEPEALRQRLLRVTLDSVSKLSLQI
RHANEVHLRWTAV
>CYP5172A1 Aspergillus
niger
e_gw1.9.995.1|Aspni1
37% to CYP5112A1
MTTWGIYSLALLIYRLWLSPLSRFPGSSLARVTYWYEFYYDWFRPGQYFRRINEMHQRYGPIIQVTPDELHISDPSYYKH
LFVTGGSRKTDMYPGTFRGTPFEGYIQIIKTHNVHRFLRGPIERYFSRRSMIAAEPRVKSCIKRFNSRMEEFEDTGRPVN
MNYALLSLTVDLVSATVCEKPTKYLSDPDFNAAWFRTRMKGIMAVPLLAMLPEPLRYGTASLFMWFVQFISSHTLVKKEY
ADCKYEQSFKDALQPSPTVNFDNTERTDAPKQQFGDDIYDLGGQLIQEGGIYPMSNCLQTIIINMALDSKKLHNLQNEIK
TFLIENPETEVTWKEIEKLPYLDACLKEGLRLVGGGMRRTTREFPDTDLHVEGWTVPRGTPVGMSSYWMHMNPETFPEPE
KFRPERWLQSEKNQDPLQHEYFVPYSKGSRDCLGKYLAHMGLCHIMFELYRPGALRLELYDTDEEIMKMGRGYLFSLPEM
ESEGVRVLV
>CYP5173A1 Aspergillus
niger
e_gw1.6.1215.1|Aspni1
38% to CYP526A2
MAPSYIASFVELFHGYPAVFSITICLVGLYVLYRWLLPSPLPGIPYNKQAATSILGDVPALRGDPAGLAKWCSKQLEEHG
SPICQALMGPLSKPVVLVADVGQTRELLMGRSDFDRSSYIIDRFPLFGEFHLNMKTGDSWRTSRSWLKDLLAPHYLHQTV
GPIIHSSVLNLIHLWESKARVANGRPFSMLADLKTLALDVIVRFHFGQDFQDSALRRQIEFVEQLDNSQLGVGKHTDVIF
PQASLHPFQQGLTDVGDRMAAIYTTKWPPSIVSWWARYMSPYYRKFFVGKDRFIRKHINLALQRFGNDEEAKTGIDYMVY
REQKASRKADRQPMYGKQIMIDEAYGNLIAGQHTTSAALVWILKLLAEHPAVQTRLRDELQTVCAAAVQEGRLPTAAEII
QFRLPYLDAVLEETLRLRAAMLVPRDATRDTELLGRRIPKGTVVLLVCQGPDYSSSPSSLYWSDVKTTRKYPGGGNPDLE
AFDPERWLVQNERGELEFDGSSYPQLAFGLGIRACWGRRLAQLEMRIMTVMMTWKFDFLDVPEALAGHEATYDISYRAKK
GYLRLRSR*
>CYP5174A1 Aspergillus
niger
fgenesh1_pg.C_scaffold_5000290|Aspni1
34% to CYP578C1
MLAVVVGFTFLVSWIVASIHRNRNSSLKDIPNAHFSAPYSRLWLLSLRWRNLENRTRIQLHRRLGPVIRIGPRDVSVNCI
DDGVRTIYSSKFDKDESFYHELFDQVGYMVTMTGNDEHRERKRMLSRPYSNSYILNSQTLGSVLSRVSSHLREKMEEWAS
TSTSVNVYQQAKCCTLDVASGWLFGSENATDTLRDPGFENDLTTLAAAASKIVSVRTTLYWPFTYFASLVGNRLPNPDAT
GRWQAWLTRAITDAYRRHPTKPSSTASLYDSFYDAFKAANPKMPRNEMASFIAVECDDHLSASHLGLGTLLAYTMYELSR
HPDYQRALRKELLSLAEPSDQSLAHRLAALPVLDAIVTETMRTRAPCPGPFPRVVPDSGCRLAGKFDVPGGTIVSSSAWA
LHFNPVPFPSPEEWRPGRWLEADESTVAEMRKWVWTFGSGARVCIGTHFSMRVIGELLATVYTDYETYLDDEFRGNVEQV
DAFSAGPIAGCLKLKFRRYT*
>CYP5174A2 Uncinocarpus reesii
83% TO CYP5174A1 A. niger
UREG_07023.1
MLAVVVGLALLVSWVIASMHRNHSSGLKDIPNAHFSVPYSRLWLLSLRWRKMENRSRIHLHRRLGPVVRIGPRDVSVNCI
DNGVRTIYSSKFDKDASFYHELFDKTGFMVTMIGNDEHRKRKRMLSYPYSNSYILNSQTLDSVLSRVSRRLGEGIAEWAR
IGTSVDVYQQAKCCTLDVASGWLFGRENATDTLRDPGFENDLATLASVASKIVSVRTSFGWPISYFASLIGNGEPDPDAT
GRWQAWLTRVITDSHRRHPTKSASAASLYDHFYDSFKAANPDMSRNEVASFIAVECDDHLSATHIGLGTLLSYTMYELSR
DPDCQRALRKELLTLAEPSDRSLAHRLANLPVLDAVVTETMRTRAPCPGPFPRVVPDSGCRLAGKFDVPGGTVVSSSAWA
LHFNPVPFPAPEKWRPGRWLEADENTVAEMRKWIWTFGSGARVCIGTHFSMRVMKELLATIYMDYETALDDGFTGNVEQE
DAFSAAPLAGCLKLRFRRLT
>CYP5175A5 Aspergillus
niger
fgenesh1_pg.C_scaffold_2000360|Aspni1
34% to CYP54B1 aa 171-515, 44% to gw1.4.1134.1
MYEEMEYALDRELGNPHEWHPLPTFPTILRIIALVSGRINIGLPLSRDPTWLTLYTKYPLTMMESVSLMKYPSILRPLAQ
HFTPSLRELDSIRDEITALLTSEYEAILSEKSDRNTMVRWLWENCEEHERTITYQSQVQAMMSIGTVLANAAAAAQCLED
LAEHEEMIPLLRGEFEGVVGGDGKDEISKQALTSLSMMDSFMKESQRFKPPGAGSLFFIGLTNNVGTIVTFERKVLEPFT
LPDGTRLHAGEHIAAPAFHVGWDPEYIENPEVFDGLRFHRLRNQGGLSATTAAGKYHYVSVNETSLHFGYGRNACPGRWF
TAIQIKLLLGRLLVRYDVTSGEGSDTVLIRRRKGGEDGV*
>CYP5175B1 Aspergillus
niger
gw1.4.1134.1|Aspni1
36% to CYP54C1 aa 275-516, 44% to
fgenesh1_pg.C_scaffold_2000360
SNKPNTMLQWVWDDSTEKDRTDEHQSMIQILATVPSTYTVAFAATQALFDLAARPEYIPIIREEFESVCDSCEEKRLTKE
AFGKMTKLDSFLKESQRITPLALISFERKTLENIDLADGTHIPKGSHIAAPSYHIGLDESHFSSPETFDGLRFHNLQQAE
FERTGKPSTKHQYVTVNESSLHFGYGLQACPGRWFAAIVLKLLLGLMVTEFDVKLMDKGEGRPKSEIDRFFIYPDSTKMV
VLRKREDV
>CYP5176A1 Aspergillus
niger
e_gw1.4.1066.1|Aspni1
32% to 671A1
MALFFDLLDIAKEKGPLLAAAGISAHVFYWSRGERSAKEGRAWVYANLIVNTLALLTTINNHGSWTSIYAWVLGISTVFV
LNICFYFSLFTSVLTYRAFFHRLHHFPGPFSLKLSKFVTGYENLEKNRNFERVWNLHKQYGDIVRTGPQELSILSAEAID
VIYGPSSKCTRGPWYDRLKGSGDFTHDYAVFHMRDPAVHSQRRKALWDKVFSGRALKSYQPMVIRTTEQFLDAVAQRVNQ
PLSVPSTMSLLSYDLMGVVGWGHSFNNIETWELNPSLHFIKNMRAGQHVMVHTPWLISLLMSLPGAGSAIREYGNWIQDR
IQEKRQQEERNEVPGEDIMTRMLPSMRGLSKKALYSEGELLVIAGGDTSSVTMSVIIYHLASNPSLQRKLQAELDSAAAK
RQKDPAPPTESPEDTYYRSISSLPYLNGCVSEALRIQPPVHGGIQRKTPPEGIHIPNEKGTSTFIPGHTLVSVPILPVQN
DPRYYRNPEEYVPERWTDEKPDWIMNRAAYFPFVGGAYSCVGKGLAYIELRVVVAMLFGRFNVRLAEGEDGRRFREETRD
TFVASLGEFRVVFSERAE*
>CYP5177A1 Aspergillus
niger
fgenesh1_pg.C_scaffold_6000319|Aspni1
35% to CYP5116A1
MTITTLMKFILAKYPYSKLCHCPYPKMFSGILKGIALLILILFVRFKYTHSFLHKTTIFKTPKQCHMIIAADGQFFDKRN
LLSPYEARTFSNSRFKSAFCIQNAFTSSDQDFVNEHVKNIKVLINLTPLEWNHLSQSLQQTARYWVNSSEGTVHLAVITQ
TLSLRLVLVGVCKLDSRISVSEDPYFADFARCINKSWILAKGPDILPFEDNEELQDYIGIFFPSCGPIQPEENPLNVILP
GYETSWRVALRMFLEIRRAENQVWVDKMVSFALHPTKVQFQDNSDGISAEALLSEALRLYPPTRRIRRTFRFENGRNGAV
DEDTFAADIEACHLDKSIWGTDALEYKPSRFATLTDEQKEAYMPFGSSPFLCPAKPVFGPRMIGMVVGILFFALQEVGSW
RLVGRDTHSANGYVSGERLNNDRGAFDDLLLYLNTK*
>CYP5178A1 Aspergillus
niger
e_gw1.16.101.1|Aspni1
31% to CYP680A1
MALFSVLSNALSELPVSIWLAAAATFAVYHAIRAVYLIFFSPLAIFPGSPWAALGEYWEAYWNIGVRPGHKGQTLFKLEQ
MHKRLGPALRMGPNEVHIYDPAFYHELYRPGSRYYKDPSMHKVLGAPTSTLAESDPVRHKQRKAPLEPLFSKKNILSLEN
MLMEHVDHCCQRFDELYSQGKPVSMEWALKSLAMDMVSQFAFGQSLNAIADPEFKSLPVRVFQQYLPSLHVIKAFPFVRL
LSSLPLWIARRISHSVEMGHELEQFAARRIDEYIEAAAQGKTPNFPTVMERLLIPIPEKGYEVPDKQGLRDEILTLISAG
DDTTGIANTVTLFNIIHNRTIHDRLLAELKTVMPTPTSHAQYIQLEQLPYLTAVIKEGLRYSSPAASRTPRLVPPGGVRL
PDGRFIPAGTRVGMAIYHIHYNEGLFENPHEFDPERWLQGPEITAKRAKFLVPFSRGSRSCLGINLAYMEMYMAIAYIVR
RFDLELVGTTPEDMKWDDMVVPQFHGEFRALTKRRVD*
>CYP5179A1 Aspergillus
niger
gw1.5.246.1|Aspni1
29% to CYP547C2
boundary between first and second exon not
clear
MRYLGIFPRDPLLLIGAVIVSWSTSFPLTVCATTLLKRQRSTFNDLPGPQ VRANTASLIFSPADANRC
&
SVNWLYDRVFDVFDEPLAKNVTAWVNERAYPGGLMHFFGLFGSEY
IVPTDHEGLVEVLSTRSYDFEKSRAFRRYSVRFFGDSLVTQEQEVH
NRNRKTFMPVFNQTNINAVRPPLTSKSRQFNDYISSLLKMSGESQRSSEGRGTAVVPVTDVVFRATMDTGSILALGIDLE
TIKGRNTHILQAFKTLFASNRQKKIRFILHNLLPGWLDQLVPSTEAKDMDRARILLVESVVNMMQGKLAKNERTGDHLTY
LSNLEQSGPFNHDEYIGQLRTIIAAGFESSGGSLSFVIYCLAANRDAQQSVREELRNAKRGRMELDXDEYERLPVLNAVV
MESLRLFPSFGLLLRRAIRDTTIKGRLIPRGTHIGICPKAINCSRELWGDDAEEFNFERWIDRSDPHNPTQVPTGGAPST
ACMLSFGYGTRSCVGRHLAMAQIKRQIALITERFYVETEDDKVPHPSGLFASTPPLDFRLRFTEVE
>CYP5179B1 Aspergillus terreus
41%
to CYP5179A1 Aspergillus niger
ATEG_08637.1
MVLQRERGLIIPNDFRLPSTCTLSYHPHYAWFFGVLPPGSVHGSTDSTLDPPAFSVY GSWARGAHIFSSSYAGGPSVGHDL
GGNLISKHVYAIFDQPLGTQITNWVNSIPNNGLLHFYGLMGAEYLVVTDVESLSDVLSNRSYHFQKTSGLRRYAERFFG
RGIVIQEGDEHKKNRKSFVQVFNQRQVDKLKPVLSAKAGQVVEHLLGLCSRQPGQDEKNYGGASNAAIKVVEFAKLVSFD
VMGIIALGIDFNSMQHHNLELFEVFQTLFATDANKQRQFMWHNCAPPCLVSMFPSTIDRQMERAYRQLRATLGQLIPERL
AALNGKDLSDQDILTQIAGSGSFSQEEIMPQIVTTLAAGYESTASSLSWTLYCLAVNPEIQCALRQEIAQAKLTKTSLDE
ESYETLPLLNGVCNEASRLYPTFAMTLRKAICDTYIKGRLVPAGTYIAIVPRAINRSRHLWGPDAEKFIPERWIDRSDPE
KPKLNSTGGSSSPICMLSFLYGPRSCVGRSLALAEIRRVTARLVEAFHIQRAGTGVVEPTGFLSSGPPSDLNLLFSPV*
>CYP5180A1 Aspergillus
niger
fgenesh1_pg.C_scaffold_9000194|Aspni1
28% to CYP5125A1
MTEALCSWLLAVACVLLIANALYYSLFQNISISSIRVVVRDFRDHRYYRPWAPKPIMIPARKRIMTELSETSVLSQRAVY
SDLFGFKHTLNGVDHNEINTRKSRLLSRVLQVRGPTEFEKLYPYLLRNLKAILDAELSSASDSLLRNALLNHPRQIKACS
AAFQLTPRFLAPLVHAIITWRGSAMHLIQDRLINTITAGIDDLDEKPEIKKLTLLYHMVDLSAADRSYWTPERLSQSILG
LWLAASHQPWVNLHAILVELCLRPEWQDLLRDEALQNQRNLARNMNELPLLDSFMRETARVNSLDRVAIRRKALKDYSFS
SAPLSIAAGSILCVSSYDVARNEHIYPDPEQFDGGRFLTGRCKDTSRKFTDVSENHLIWGYGSLAWFAQFFPGRHHAAFM
IKMVVVHIVTNFTLQLADPEAPRWWTWEDFRMPYASTRVLFSKRTTKTDAIS*
>CYP5181A1 Aspergillus
niger
estExt_fgenesh1_pg.C_100184|Aspni1
31% to CYP534C1
MDVFIWRLFLGSATVLAGFTSWSLVCLILNVREARSTGLPYVILPCSLLGAPWLLSQPVVLPLLKALPRTWTSKWLPLLI
FNDGWHLGYTPFEQVGADTFLAVSPGGFVLYTCDRHVSTQLFQDGRFGKPAHLMQVLNIYGPTITGTDGPESRLYRRITA
PFFREDTLRQVFTHAIEGAQVLGLALNQPAAYHQLRTLAARLSLNLLTRILRLTTMWSTVVMALLIKAVSAWSPLKSHRQ
AIRAYDDLGQYMHELKTTTESRLQDKEYLLNQKGTASLGDLIVQAGISTDSSTSPILQPHQVMGNVFLFMFAGHEANANT
LTFVILLLACHPTIQTAVQSDLDKILENTPPSHWSYDTHYEPLMRSLVGAVIKEALRLFTVLPVLPKYVPPSGPAIPIVV
SGQSHPLPPGTVAFVNTSATHRHPHYWPTVNDKSAKSTNQEDPTLRPYPTTDFNPYRWLETQPSGSAPDNETRLRSSTGF
TPAPGTFVPFSEGSRKCLGHKFALVELCAVVALLFHQNSVSLLTDPADPSDTWAAARIRADRALSEGVKFNMSLRITQDV
PIRFATRKTKAT*
>CYP5182A1 Aspergillus
niger
fgenesh1_pg.C_scaffold_11000427|Aspni1
33% to CYP609A1
MFGAACYALTQCLYLIAVLLLVQCLRLLWKHPFPANAPKLVSGYPLLGALQFFSDRNGFCRISKAASPSGNYSYYLGRHR
MVGLCGPQGRKVFFESQDLDVDEGVAVLLPFVNLVEASNDPSSDTHTAYLRSTLRTRLLRTQSLEFVPHTIGTYITATLN
HIEAEGLIDPFPEMNLYYTQSTMAVLGVEKVARSPELSRKIGELLGLLEGTFSATDIVIPWLLNPSHLRTVIGVARLYVM
LWQIIGNQKMEQQQQPLSHKQESENVGILQDLITKGRSMRAMLQANSPTVTSWMLIMLATNTHWMARVRQELNQVVSKHR
KDGESADQVLQGLGVSTWEHEFPLLHACLLETVRLVLGLVTIRKNISPNDIPIGDKGEVIPSGAYATYDLQEVFQDPAIY
PDPQRWDPGRFLSDRAEHMKEYLAFCGFGAGRRKCRECASYIYHDSIF*
>CYP5183A1 Aspergillus
niger
e_gw1.7.1018.1|Aspni1
34% to CYP660A1
MVLDCTQDSREPPAVDLSIPFISPFFRMCWTGFDYYRKNRRFPIYTIRLPGLRLYVVNSTSLISAVQHHPRTLSFSPILA
RVAGTLIGATKPGCKVLGDDDENGFIRRFHDFNQSALSAGPGLEAIRTRFWELVTLSQSRQYTDSPGYPGMYEWISHEVM
MATSEAMYGVQNPFRDPGNRAAWQQYQIGTTRLTIGWLPSIIANQPLRAREALVQSFEQYYSKRGFEADQASSYMKDQYL
VFSRSGLSDSDIARTQAAFSIAILGNTIPAAFWLLYHIYSNEIILQDCRKELYAALQKRSQENDDHRPMLDLSSLEQSCP
ILASTFKETLRTHSMGTSVTQVVQDQVINNQYLLKKGSMVMIPAIIQHSDPSVWGDDVNEFNYRRFVRQNTNDRKRSHNP
VGFRVFGGGWTLCPGRHVAASVILGFAACTILNFDMKPRSGEWVMPTVEKSHLGAAIAPPDEDIDIEL
>CYP5184A1 Aspergillus
niger
gw1.4.1747.1|Aspni1
32% to CYP640A1
GHTFSFLRNIEKTIDNAMPYLKTEDTPFRLHVGGRSLYVVQDVRLISEIHKQTKLIGNDHFLDILMAASGVLGPTRARLW
STITAKRQEPIPRAITENVRRGLRAQPQNNPLTLTILAQMDKTLTPLAASDSLRRSLAEPGKVSLFKWTVDAFTVTVSDG
AFGKVCLDMFPEVVDTMFLLQTNIYSIFTRRPRILAPKAYAASDKLACILAKYFALPTEKKLDCAEFVTMTEDEIRAAAV
TKEELAMMYVWVFWGMLDNPSTAAFWVLCRVLYNPELLATIREECEEAFVRNKPGAPSDIPARLECCPILKSTFEETMRL
HSGTHVFRHISEDTEIGPYRLRKGSNILIPYNRIQVSKTHW
>CYP5185A1 Aspergillus
niger
gw1.1.1982.1|Aspni1
45% to CYP5083A1 aa 298-455
M T L
T V S
P N L
F A Y P
S S L
H K P
S P E
G L P
P A L
L S
GPVVRIGPSELSFATHSAFDTIYGPYGDKNFSLYGS
RKGLLGSLGGMAESLGNSTDKEN
RRKLRPLVATSLNELLAAKGEEYCHLAMDEQLASHHVGQTEATPVSLSTLNNRYLW
QFASMAANGNRGDETDRGTSFTNIFMGLSFMALTQVIVSFDPHVDWLDRFMCFLETLFIF
FSIYGTADNMLNALFYFLLRNPQCLKRLEEEVSCVGATVNELSDDRLAKLPYLNACINET
FRIAPAFNGGILQRVSCGATVDGVYVPPGVA
VSVDHYTLGHDPQYWVKPDVFNPERWIDPDCKDNFKASRPFLIGARQCPGRQMAYQMFRVCVAKLVYLYTFEL
LNKDFDIERDTFSSYHWTGVKLDVTMKPRTPGVLGY*
>CYP5186A1 Penicillium citrinum
BD294644 patent seq orf16
10500-12300 (+) region MFS transporter (orf17)
13160-15000 (-) region = P450 (orf16) 32% TO CYP660A1
METIGLNITLLSLKTWIAIAVVAFALARFVLWPSGDPK
EPFYVPARLPLLGHAINIYNKGSRYFVEIG (2)
SKKYKLPIYSLPVPGGRVYVVNTPELLTSVDRNPKAIAFGPIAAMVIERLSGSKGRAA
1293
SALREDVTGPNSANGYMNAVLKQIHHTLAPGPLLEKVTDAVITDLNDSIGGLQHKETTIH
1113
LLEWFRHNFSMSSTNAIYGPKNPFKDPKVENGFW 1011
FDYAVSNLLITPKASWTTPQGDKGRSD 869
AWNGFIDYFRQGGHNEGSEMAKQRYEVAIAKGIPIDDIGRLEVTMIIGVLTNTVPAGFWM
689
TYYIWSTPGLLDELRGELDKIIIRETQPDGRPKLTLRSADIKQDCPLLYATMQETLRMRT
509
CGISSRIVTEDIVLNDQYLVKKDSVMELPNNIIHSAEDLWGPTVCQFNNKRFIKGHPDY
332
RVPKNGFRPFGGGVSLCAGRHQATSQLLSALGFLVAAFDISPTKGAWDFPGAHGHTIAAA
152
MDSPDHDVQVKLQPRQGYEDAVWTLKP*
>CYP5187A1 Mgr028 Mycosphaerella graminicola
38% to 65L1, all top hits are to CYP65 sequences, but low
30% range for many
LYRSFCGPLSDIPGPKWRKFTNLPHLYSMWMGREATDVAKLHQKYGDTVRLAPDLIAFLGEGDLWKDIYASKANGVCKFR
KDRLYYDVPVNNIPGPVSAQCEAAGRMRKTMAPAWSDQGLRQHETRFKGWCKALEYRLGIQASQDMPTDMVKMFNCKGTT
FDIMSDMLLSEPLHMLEKGEYAPLVSLVFWLLKYVTRLKTFRYFSRTYGPKLRGLIMKIPAIGRIAREHHHSVTDRVDER
MAKEPEQPDIWSLVTANTSTASLISTQERYSIANELMMAGTETTATTLSGIMYNLLQNPQWMSTLCEHLRSQFADIESLN
MAALQGDKLLNAVIKEGLRMYPPIPVGFPREVPDEGCTIKGHFFPPGNRLAIYNYATYSSEKRFREPRVFHPERWMGDEK
FKDDRVDSFEPFSVGLRACSAQNFAWHEMRLILATVLLNFEFELRPESTNWAEQKTYIVWEKVPLQVNVRKRV
>CYP5188A1 Mgr074 Mycosphaerella graminicola
38% to CYP65F1 Magnaporthe grisea, all the top
hits are CYP65 members
yellow from JGI model e_gw1.1.671.1|Mycgr3
VKIIYNVCFHPLRKYPGPKIYAASHLPWGYWYRKGVWHEKVLQLHKQYGHIVRVSPDELSFDIPEAWEEIYSRGNNKVENYRPEWFATSKQNFIIGANESDHKRMKAVMAPCFSHAALTEQEPVIKRHMDSFIRHLQEATDGGQKPVNLIRWINYLTFDIIGDLLFGEGFGCVEGDEEMRAWQDVLIVNLQLIHVLAVCQRVWVFWLAMSPRNLWHLVTKFAYFDGLIDARVKARDANEDREKTDFLDVMRKGRKTAQMTPKELSANSFLLTFAGSESSANATASLVYRIATNSTLRDKLLQELHDNFQHEDEISCAKAMALPYLAAVIEEGLRLHPVTPNALWRITPKQGNKVFGEWVPGNTVLSIHHRAMYYGEHNFKRAEEFIPERWMPHSDASSDFADDRRDAFHPFSYGARMCPAKNLGTAEMSVIIARLLWAFDITIAEQSLRWREGLRGWALWEKRPFWIYLKSRAKYESA*
>CYP5188A2 Mycosphaerella fijiensis
65% to CYP5188A1 Mycosphaerella
graminicola
fgenesh1_pg.C_scaffold_11000257
MSWSSLLGTSVLLAVIYYLIILP IYNIYFHPLRKYPGPKLFVASSLPWGFWYRSGFWHEKIEELHKQYGHIVRVAPDELS
FDIPEAWDEIYCRQDTKIENRRPEFFISSKLHYIISAKDSDQRRMKNVLAPGFSHAALTEQEPIIRRNMDLFIDQIRQES
CVAKKPINLMRWVNYLTFDIIGELLFGKTFGCVAGNERFRAWQDLLITNLQLLHTICVSKRIWIFWLAMPWRDVYTLLTQ
FTHFDKLIGNIVNERLAGKAPDRTDLFELMKQGRGGNCMTQEEILANSNLLTFAGSESSANSTVSLLYRISSDATLKARL
LRELRANFKSEDEMTSTKAMTLPFLRAVIEEGLRLHPVTPNALWRITPKQGNKIFDDWIPGNTVLSIHHRAMYRSEHNFK
RAQEFIPERWMPNSDIYSEFASDRRDAFHPFSCGPRMCPARNLGYAEISIILARILWNFEIVVAEESRHWRENLKGWVLW
EKRPFWLYLIPREEYEGNEAKIAEPGNDHGTS*
>CYP5189A1 New seq gw1.13.670.1|Mycgr3 Mycosphaerella
graminicola
This seq is like no other P450 except at the low 20% range
This seq is 45% to CYP5189B1
MGHLNEAFRALWS
SSLVLAFSLAVAILLACFLRSWRGGNDKRLSPPPAPYTIPYLQHLPAFLWNPGKLYRSMQ
ARYLGPFTLLLNNTKFHVFQESSTVDYVLSHSRTFTFDPVLASMMENGLSLPTEDL
SRFLPPADSKAEDLSKSRSFMTMNHNIWSKYLSGEPLDKIMAIYTRNFNSILE
QHLDLKSSKWQDVDLHELITRLIFETSVLTFFGSRIKEIWGDSIWDDWKLYDEAMY
IGVRTKLPFKLQPRVHFAFNRMMSAFQQWIASGSIEWPETDVVRNDEWGVRLNW
ERDRLAVAHGFSLRGRACLQASFLYV (2)
MLTNAPPLATWFAFCAAHTQESLDRYRAAATAYIRPPMDSGELSLDIAGMKNDPYIQGLWK
EALRLGMANAVARVVTKDAKLEGFEIRQGSVLLMPVELMHMDERTFPSPQEMKPER
WMIDDENTLSMQNKRLRAFGGGKSLCSGRFVAEHEVIGVVSQLLLRFDVE
FDERSRKWQFNPRSHGAMKPKHAV
RCRMRPRQI*
>CYP5189B1 Hypocrea lixii cDNA AJ894250.1
(anamorph: Trichoderma harzianum)
WIPRAAGLYPARTFRTTQKKYKDSPYTLLMGGVKFHVFGSPSAATHVFARSRTYAYEPV
TMSMLENGLDLPVADRVHFQIGLDRANSSDNEKGFVLQNHNVWLRYLSGEPLDDLM*LFT
REFHQVLEQYVDMKTRDWQTVDLYEVLRKVIFDTSVVTFFGPRLAQIWGPTMWEDFCLFN
NATYIGVRTNLAYVLQPRAGRARERMLRAFEEWLSHQSEGDWPDK
>CYP5190A1 New seq fgenesh1_pg.C_chr_4000706|Mycgr3 Mycosphaerella graminicola
32% to CYP5116A1 Aspergillus oryzae
MIQVIKFFIRASGQVFARTSEGVVWICRGIQAWLQLSLRQDKVKLTDSAGCRNIIQAKVVQRPGSEAQLKNLIPPFESRA
KPNKRLVHAFGINNCFTTAEPQRCTTFRLEATRLIRLRGPEWKELSQTVLQVVKHSVPLQTQAKSNLFNLMQIVTMKSIL
GPLCGFDSSRSDVDGELQTLAKEINRQWLDSKEGLEKETEFANQPKLKSALKAIAPTWDGLDDTHNPLNFILPGYETLWR
VVLRGFLEVMYRANERDSANWRHALEDFALNPTLAQLDKVHTDYGKVSTCMIVEETLRLYPPTRRIYRTFKVAEDEEFEA
AADIEGLHRSAAAWGNDALFFNPSRWADKVNDTNFRNDNFMPFGTKPFTCVAKTGLVNEAREKCLPFGVSIIAILLGCFS
AEVPAGMTPGGGGADGTWSTDQPLKTGREDYRDVMIGY*
>CYP5190B1 Mycosphaerella fijiensis
41% to CYP5190A1 Mycosphaerella graminicola
e_gw1.6.477.1
MSSLDVFLGGVAISVLVSICCYGSAKDNYYWFMGLVVPTLAALRSLGTDLGIPSLLVSVLDTF
MLACSGIVVGGAVWSKVCSILEQVATKESTLPQTQVQTLCAKPKDCLTIIDGKKMPDGTINMMNKFEARATPNKRLVTAF
DIHNCFTTSDRLVCEEFRKAVEEKIYFPEAKWKELGAIARSIVKNELNRSTSELSLFEVVQSVTMQMVMTVFFDTSEISV
PTSSIRCLAQEINDQWLRSKDKTSPGQTASPDWSFHKQQPLREALIAAFPAWNGSKDTNPLNLILPGYETLWRVVLRCFV
EVSSRNHSNSPQWQSSLANFSLNPTRKELEKTGPIPCSSMIAKEALRLYPPTRRIYRQFKDEQGDEYEVAADVESMHRDI
EVWGKDAKVFRPERWYSVDQKFEDCCWLPFGAKPFRCPAKRWQLEGVLPFGVAMIALLTGALLEGGWVCGGGGGFQDDVN
EPLETNRHAYKDVVLRRLGGNGLTTKFGKEAL*
>CYP5191A1 Mgr046 Mycosphaerella graminicola
32% TO CYP559B1 Magnaporthe grisea
C-term from JGI model e_gw1.1.632.1|Mycgr3
revised
MPLASADIYNIAWCAGILLAGYLLLTLLGNPFVSSQDKFLDSHTCLGQNKQCFFSRFRADLASVFQSSALAREGYEK
(0)
FSKMGKNWVMPQFCADRVIVLPAQKLQEVMSLDDDQIDHLGPLNDAFIPKYTTGIDVLNGPHVDIVRQKLTRRLPLMTADVYEELVLAMERVWAPKQDEWTTVKVLESTMKIVGQAANRMLCGPELCRNPVWLEATRRHAITAFATGFMLRPFPGWTHPITGRIAAIPHLLSLRKCKRMCTPIIEERLRNTLDPTTTKTSEAPFDLLQWIVEDTIQRAQAESKTIDMDVIVRQLLILIVAAIHTTTIMTTHTLLDLYSHPDANTYVEGLREECERVFAESGGKWTKVAVDKLIRVDSTIRESMRLYPFVDLSLRRTILPPAGVTLSDGTHIPQGVTLGFTGPFIHRDPTFYPENPEDWDGFRFSRPRERGIKVDLETILEQKNTAMTAVQVDFLTFGLGRHACPGRFFAS
QEMKLMLAHIVMNYDVRVAGGKRPPTANIAGNYLPDESAKLEIKLRER*
>CYP5191A2P Mycosphaerella fijiensis
46% to CYP5191A1 Mycosphaerella graminicola
45% to CYP5195A1 Mycosphaerella graminicola
note this match is to the bottom part only
There may be some overlap in the CYP5191 and
CYP5195 families
e_gw1.41.26.1
METSITTSRLVFSAGALLIAYIFVTALVLPLLSSRGKYLNSQAWIGLKKQWFARYRGGFATLKYTREMIVEGYEK
(0)
(about 77 aa missing here)
FSRHGITYVISAEQNWPANKT
EWTRVKTHPTCMKIVSRAANRVFAGKTLCRNPEFLEHCRLYAVSVFKTGAIMRTVPKLLQPIAGPILTRGMRKHFQICSN
IAVPEIRRRLAHLQGHTKDPNYEVPNDALQWLLVDCIELAKSNPHELDENLLVRRLLLLNMVAIHTTSMVISNTLLDLYT
SPSKEEYLSGLREECERVLSQHNGIWTKEAINSLLRIDSTIRESMRYSNLADLGMKRQVIHPNGITLADGTHFPHGIRLA
APTYSIHLDPKFYPERPDSWDAFRFSRPREDYLGKISAGADPDRLQRSLALKNSALIATGCEWLAFGHGRHACPGRFFAS
QEMKLLLALVVMKYEVRIEGGKRPENWRINGAVVPRDEVEMFVRLR*
>CYP5192A1 Mgr047 Mycosphaerella graminicola
34% to CYP59D1 new family
MFELRTVLLAAVAIGIAYVARGLVNGYKLRARRQGLPGPPHSWLFGDLGTMGKINDANPARAHPHAVLIQVRKMFNLPRY
MYLDLWPITYSILVVQDPDMAQQVVVEHQALKHPIPKDIMEAVVGPDDMVTMDGPQWKMWRTMFAPGFSNKHVMSQVPGF
VDDVNIFIERLSEHAERRDVFRLFERTSRLTVDAIGRSVLNIQFNMQRGDHAFFRALTQQLQLLENGPFGILTGWSPLVI
YQKWCNNRIMSDYFGKVLDDAYAKRRLQREIKDDSGRTTLDLALDSCFAGESSIVEARPEKLNPTLRTGIITQLRTFVFA
GHDTTAATICYLFYVLSKNPTCLQRLREEHEIILGSSSTTASTLKSSPHLLNQLEYTHCVIKETLRLYPIGGTVRSGSPS
LHLTDRETGEKFPTDGYMIMIDQYGMGRSEDIWGPDANDFNPDRFMPENSGKIPKGAYRAFELGPKNCIGQNFAIMEMKV
VLALVARVMEFSTALDE
>CYP5192B1 Mycosphaerella fijiensis
48% to CYP5192A1 Mgr047 Mycosphaerella graminicola
gw1.15.75.1
MPQLHIRLVLTAICAIILAYLGRFFYIGYQIRKRHRAL (0)
PGPPHSWILGNLKVMAEVAMALPRRVHPHVFPALVRRKHRLASFFYVDVWPMSDPFIAVMDPDICQQFSVEHQPLKHPSLRT
FLEPLCGKDDMLSIDGAKWKKWRSMFNPGFSTQHLTTLVPGIVDDCLTYCDILSERAKTKQIFRLEEASTRLTIDIIGKV
VLDLHFNMQRGDNEFIQALREQVHLLPNEDQGMHPLQMWRPYGIYRRWKNDRFMKQYLGKLIDEEFASKDIATIKKQRRK
TVLDLALDSYLSSNTHPEKGIGTKPKALDKTFKEGAITQIRICLFAGHDTTSSTICYAMYMLGKHPEVLQRLRLEHENIL
GPISQTASNIKSDPYSLNKLEYTTCVIKEVLRLFPAASAPRNGQKGLFLHDKKTGAKYPTEGYMIWLIHYGLGHNPEVWG
EDYNTFRPDRFLPENAHKIPEGAFRSFEIGARSCLGQNLAILETKIILALICRSFEF*
>CYP5193A1 Mgr077 Mycosphaerella graminicola
35% to CYP609A1 Magnaporthe grisea (new family)
MGLDSRIFGTIDFKSLCVYALVGIVTFIVLALTGRPKQSSKKLPVPAQGWRPFVGMIRFFTDRQSFVLDNIAASHTGNFRFNIGRHNVVCLAGIDGRKAFFEHKNLDPEAGYAVLFNSAPPQPAKYVASRTGAKSSEFMGWFLLKIARFVHKDYLNEVLPKLLVDGRNQFERRISIKDDATYDTIDPFDQVYKIVYKLTIRTLGPSDIADDEKLTEQTLRLFEMIASSASAAKIVFPYLPTPGHVKRMYAGARLYALFRKLVRDRKKSGKRGSDTLQHFVDEGEDELKVMKFVFGAIFAGQVTTGVSAAWILVYLAVNPVWYRKIQDEVDQVLQKWDGAGSRHSPFEVFGQMRAEDWETSFPLLELCLKETIRFQVPTAAIRQNLGDVDLPIGNTGEIIPKDWFAVYLFDEAHFNPKIFAEPDKWDPSRFLEGRKEHLKEPHCFTAWGSGRHPCGEFSRFAKLEVKVITACFVALYDYHAVGADGQRISHQPKAARANTLSPRPVEEVRLRYQARRASRD
>CYP5194A1 Mgr081 Mycosphaerella graminicola
38% to CYP570C1 Fusarium graminearum
38% to 527C1
(probably a new family) yellow is extra here
MSLLSAHNLLLAFSAFSILLLLRLIVALFQNHAQLRDFKGPGLAAYTRFWIFKEEVAGRLPHSQRAALRKYGSPCRIGPNLLVTDDADLIRHMNAPGSRWTRSSWYEAMKMDPRQDNVFSTRDEKLHAELKAKEYGGYNSPSIEPLIDSLTTQLLTLISTHHPSQPFDLSSTIRYYVLDVLSTVAFAGPFGFMAQNRDLWDYQKTSNAFMLLLGLSANHTFFRSLLSHPFMQYLAAPKLTDTTGLGPALKFAREAVATRFGPDAEKEKEKKDLLGHFVAKGLSQLQCEVEAFLQIAAGSDSTTTVLRSTLFLLASNPPAYARLRAEVDAADTSRPVIKYTESLRLPYLQACIWEGCRLYPPLFGLKSKTSPPDGETIKGVYYPPGTEVAICDDAVMRNPDVFGERVDVFEPERFLVEDEEVRARRLRTVEVVFGSGRFLCLGRGIAMMEINKAIFEIFKTFDLVVADPMRGIDMVRHNVHVQSEMNVVAYPRSR
>CYP5194A2 Mycosphaerella fijiensis
59% to CYP5194A1 Mycosphaerella
graminicola
estExt_Genewise1Plus.C_150125
MGSASGLLIPAAVLFFSYYFIGAIISYRRLSQFKGPPLASFSRFWLFWKECAGQLPRSQVAALEQYGSPARIGHDLVVTD
DADLIMRMNAPASKWTRSGWYDAMRMDPRRDSVFSARDEKLHAELKSKEAGAYNGRDIASLEPDMEARIGDLIELLRKHE
GTSVDFASVARYFTLDVLSTLAFGRPFGFMAADEDLWEYNKTSRDFMLILGLTANHSPIRWLLSLDWVQALAAPKLTDKT
GLGPALAFARKAVAERFGPDAKVKKDMLGSFVEQGLPQLQCEAESFLQIIAGSDSTTTALRSCIFLLAGSPRVYCKLRHE
VDAASSQAPTGSVIKYAAAQKLPYLKAVIQEALRLFPPLFGLKEKTAPPGGEEVGGIFFPEGTGVAICDDAVCRKKDIFG
EDAHIFRPERFLEKDEALNAKRFRTVDVIFGTGRFQCLGKHIATMELHKSIFEIMRHFDFVMTDPMRGIDSVSHNIHMQS
NMNLVMYSRT*
>CYP5195A1 Mg004g06980 Mycosphaerella graminicola
31% to CYP606B1 Fusarium graminearum
40% to CYP5191A1 Mycosphaerella graminicola
MEQHRVSSSPILTTAACLLLAFITYSFVAATFSTTARFWRRQTWVGDRKGLFSRLRTSIASITGSRAMVKDGYDRLSKNGQPFALQQFANPSVLLLPPAKISQLLQKSDDEIDLLKTLQETLAMRWTGDMDLSEDPIHIQVVRRQLTHKLPLLTADVHAELVLGFEDQWKTSTEWTAVPAATSCANVISRAANRVFSGTELCRNQEFLDACRSFGEGVFMAAGVINMIPTWLRWAVSPLITSRNARNMAICKRIGVPVVNKRIEEYKSGAEPRNDALQWVIEESLKRADPKEHDPVRICRRIVRLNMVAIHTTTISITNTLLDLYGSPRAEEFVAGLREEVERVLKTHGNEWTKGAVNDLYRIDSTIKESLRWTPLSLVGLTRLVTSKDGIDLGDDLHVPHGVLVAAPNVAIHSDEKHYSNPAEYDAFRFARNREDQDGNVVKQKSQGIVTTNESFLTFGHGRHACPGRFFASQEMKLMLAHIVMYYDVRLPGGRPKNFDFKGASVPSRRAVLE
>CYP5195A2 Mycosphaerella fijiensis
51% to CYP5195A1 Mycosphaerella graminicola
e_gw1.34.29.1
MLSSLDLPRSPNFFLQASASICISYILLSLLLNYFSVQARWFRKQEWIGYRKEWFSGVRAHLRSILGTRETVMA
NYERLNNQSFLAIPQFMSKPLLLLPPKKLRELCQKSEDEANLYIVLTEFLAIE
(2)
YTMQDDVTRDPFHLSIVKHQLTRKLPIMTADIQTEL
ALGFDQHWQVDVGNEWRTISAFGTCTSIISRAANRVFCGPDL (1)
CRNEEFLKHVNHYSEYSFRTSGILNMLPKWMRPLAGP
MIARRMLRAPLHACRQHAVPVIQERVERIRYGMQDEVH (0)
NDALQWVIEQCIARDDALELDADRILRRLIGLNVVALHTTSIA
MVNALLDLYSSPRAAEYVEGLREECSRVLKSYGGEWQKGVVNELFRIDSTIKESMRLHAIFTVGTLREVTKKDGVDLGDG
WRVPHGVRLATPIVAIHRDEHFYPNAYEFDAFRFSRDQEQVDGDKATLEKRSQAMVTTSESYLSFGHGRQACPGRFFASQ
EMKLMLAHIVMNYDVKLPGPRPKTYDFKHASVPDPRSQLMIRRREAPAEV*
>CYP5195B1 Mycosphaerella fijiensis
44% to CYP5195A1 Mycosphaerella graminicola
e_gw1.8.136.1
MPWTLEPAVLLWKATFFLIILYITSYLSIKTFGRRARFLRSQEWAGSTKSWFPQWSWKS
MTHSRSLTIEAYNRLSKHDRPFVIPQWGKEPFLILPQSQMREVYQRPDADVSIMAMLRDNLAVRYTGDSDIAVGAFHIDL
VRHDLTRKLSLFTPDIYDELSLGFQDEWHPKSDEWKPILLYETTIRIVTRAANRVFSGTELCRNAEFLEHTRLYGYQIFT
QGMLINMIPISFLRPLAAAFMTRKSVHHRNMVLKHAAPVIQRRIEAVRAGNKDPPVDCLQWLIEKCVACNDPIELDVTMI
TRRLLRLNMLAIHTTSLAITSAIFELYSSSRAQEYITALREEVTQVLKAHNNKWTKAAVTDLHLIDSTIRESMRINDFSV
FSIARTITSPHGIDLPDGLHLPPGTKIAVPNLGIHRDPTNYENPNEFDAFRFVHSRESMVLTSESALHFGYGRHACPGRF
FAAQEMKLMLAYVVLNFDVKIAGSGPRRTRDLKAAALPDAKAEIWIRRRHI*
>CYP5196A1 Mgr003 Mycosphaerella graminicola
41% to CYP5076A2, 39% to 5076E1, 41% to 628C1 (may be a
new family)
52% to Mgr067
MASTALLLFGAGAASHLAYFRNGEHHMHSVRYIQAFTAVFIASTLGLVNYNGDTVSSAITTTTFMSCTWLAGVYSSPLIY
RCFFHPLNKFPGPFPARLGSLWLTSQLTDWKGYKLFQKMHKQNGRYVRVGPNTLSITDPDIMQPAYSAGSKVIKGDWYDA
SYPRTSMHTSRSKPLHDRRRRVWAPAFSDKAMREYETVVYDFNNKLVEKFDEHVGEPVNVSTWFNLYSFDIMGRLAFGKD
YGMVEGGKRHWALDLLVEGMELTGLRMPVWLIRILMAIPGLTKGYWDFIKFCQDEVTWRVHNGKADSNDIIGWLLKAYAG
EKNPDKDPMLVADTQLIIVAGSDTTSATLTFLFYYLAADPSQQEKLREELKPLINSEKWSDKDIQNAQHLNGAIDEALRL
HPPVPSGLMRQTPAEGVQIGEVFIPGKVDFFTPLYPMGRDETIYEDAESFVPERWYSRSEMVKHPDAFAPFSMGPFNCIG
KNLARMELRTLTATILLKYNVAFAPGEDGTMLKDKLRDHFVVSPGELNLVFTPIAT
>CYP5196A2 Mgr067 Mycosphaerella graminicola
52% to Mgr003, 44% to Mgr013,
38% to CYP5076A2 (new family)
MSTAAAPLAISSLGAFAAGTGLYWLYFNRFETHMHALRFINTFLLANIAGFFALTASYGLTTSAAFSTLTWASGALLAAL
FGNCLVYRLLLNPLNRFPGPYPARISNFWLSTQLAAKSDGYYWLQAQHKKHGKIVRIGTNDLSITDPEIMELAYGAKSRV
TKSIWYDGDKPLTSMQTSRDKGLHDRRRRVWAPAFSEKAIRDYETEIQTFNDKFLTKIAEHGDKPVNLTKWFNLFSFDAM
GLLAFGRDYGMLDKGEKPHELEMLDEGMQPLAYRLPLWFFRLLTAIPGLSAGYQKFVNFCVSELTWRVQNEGNTKRDVDI
MGWLLKAYKDVPHPEKDTMLQADARLIIVAGSDTTAATFTYLFFHLAQNPEIVEKLREELDPLTTGDWQDKDIRNAPILN
GCINEALRMHPPVPSGVERLTPPEGLKVGDTWIPGNVQFVTPMFVMGRDPDIYAQPDTFLPERWSTQSDKVKHKDAFAPF
SMGPMGCIGKNLALMELRTLTTRLVQKFDWRLADGEDGSRILRGTKDHFTVDLGDCEVVCGERRR
>CYP5196A3 Mycosphaerella fijiensis
63% to CYP5196A1 Mycosphaerella
graminicola
e_gw1.9.877.1
MAVENLPTHALLAVAAGIASHVFYFRIGEHHMYGVRYIQGFLAACIGSMIYLTNAVGHSLPSAARTVGALAVCWLVGVYS
SLIVYRLFLHPLRKFPGPFGARVGMLWFTAQLGKLDGYRHLHGFHKKYGKFVRIGANVLSITDPNIMQLAYGPDTKVVKG
DWYDGAAPHHSMHTVRDKGMHDRRRRVWAPAFSDKALREYEPRVREFNDKLVAIIGEKQGKPMNMSDWFALYGFDVMGRL
AFGKDYHMLDNGKRHWAIDLMTEGMTFSGLRFPTWVFRVLLEIPGLAAGYHKFLKFCSGEIKWRVENAEKSGKDITGWLL
KAYTNEKHPEADPMLQGDARLIIVAGSDTSSATLTYLFYELAKDPSQVKKLREEIKPLIHDGWTDKDLVNAPHLNGAINE
TLRLHPPVPSGIYRRTPPEGLHVGDVYIPGDTTFFTPQFPMGRDEDNYAAAESFVPERWYSKPEMVKHPDAFAPFSMGPF
NCIGRNLARMELRTLTTQLLLKYDVHFADGEDGTRLLTKTKDHFTLTVGQLDLVFTPATS*
>CYP5196A4 Mycosphaerella fijiensis
74% to CYP5196A2 Mycosphaerella graminicola
estExt_Genewise1Plus.C_21242
MANAPLSTGTASLGSFAVGTALYWLYFNRYETHLHAFTYVVTFLASYTALAVVLINTYSNTILASAAFTNVVAASCLIGI
YGNLLFYRLFLNPLNKFPGPYGARISQFWWSFQLGKADGYYHLSDWHKKYGKYVRVGSHNLSITDPEIMELAYGSKSRVG
KAIWYDNDKPLTSMHTTRDRGLHDRRRRVWAPAFSEKALRDYETEIQRLNDKFINQMVNHEGSPANLTKWFNLFSFDAMG
LLAFGRDYGMLDKGEKPHELEMLDEGMQPLAYRMPSWFFRLLTHIPAAAAGYQKFVKFCIDELTWRVKNAGETKRESDIM
GWLLKAYKDVPHPERDPMLQADARLIIVAGSDTTAATFTYLFYHLAQHPEIVQKLREELEPLMQGNWQEKDIRGAQCLNG
CINESLRLHPPVPSGVERVTPPEGLQVGETYIPGNVTFFTPMYCMGRDPDIYAEPEKFLPERWYSQEDKVKHKDAFAPFS
MGPFGCIGKNLALMELRTLTARIITTFDAKLAPGEDGSRILGKTKDHFTVDLGDMEVVFSQRT*
>CYP5196B1 Mgr013 Mycosphaerella graminicola
39% to 5076D1 38% to 628A2 (may be a new
family) 44% to Mgr067
MAEVFHPSLLLTAAVAGVATHIVYFQRCEYTRHMRTLVWLFLGAIAAACILTNTALIGTFVTATILSTLFYRLFLNPLNR
FPGPYLARLSNFWIAFHVGKDLNHHLKLEALHRQYGSIVRVGANRLSIIHPDVIDAGLKNDSVASKGPSYDHDHPHSNLH
GLRDKKVHDKLRNNVWAPAFSDRALREYEPQVRVFVDKVLAQIAKREGQPMNLSMWFVLFSFDVMWALAFGKYYGYIDAG
ERHEMQNILDNAMAVLGLSLPQWCGLLPLNRGCVELEDSVRNNFAQKDDAELKLPPGKVISSYLLEHYKKAPNPETNLMF
QSDARLIVVAGSDSVATTTTFLFHELAKHPEIVSRIREDIRQILGDRSVEEYTDADGVRSKYLNGVINEALRLYPPSPAG
VNRDTPPEGMRVGDVYIPGNVNFNMPGWITGRDESIYVRAHELIPERWYSQPELIKNRGAYAPFAKGSWGCIGKNLALME
LRSMTANVLLRYDMRMAPGEDGWRLQHKSQDHGMMCLAPFEVVF
>CYP5196C1 Mycosphaerella fijiensis
47% to CYP5196B1 Mycosphaerella
graminicola
42% to CYP5196A1 Mycosphaerella graminicola
e_gw1.29.250.1
MTSTGLILYWGLGVAAHLVYFQRYEYWRHLYTSLTAFAAATILSPFVLVKYAGTSLWPSAIRILIFHASFLLGATSSTLF
YRIFLNPLNNFPGPYFARLTDFWLAWYVGSALDQYRKLDGLHKRYGDFVRVGATTLSVANPHAIDAMLGYDSPALKGAWY
DIDYPNPSMHGTRDREAHAKLRQKWAPAFSDKALRAYNSRIKAFTKSFIGQIAELDGKPVDVTKSFSVYSFAVMAGLSFG
KDEQMLQVENLPQLIKIMSDGMKLLGLLPPMWFIRLLKLIPGDPSGMKKFHAFTDSHLEDAVRSNFDGASAEPGSIMSSW
LYKMYQHLPDPASNGNFRSDIRLLIVGGSETVAITLTFIFYLLAKHPEHIGILRSELRHKIKSETWNDTDIKNCEHLNGV
INEALRLHPAGPSGVYRLTPPSGMRVGDRYIPGNVTIGMPIYVIHRHEAAYAQPDEFIPERWYSRPELIRNPKALGTFSG
GRFGCIGKNLAYMELRHVTASILSQFDVEFAPGEDGSKLLHESLDHFTMGLAPLHLCFVPAKDPELP*
>CYP5196D1P Mycosphaerella fijiensis
47% to CYP5196C1 Mycosphaerella fijiensis
fgenesh1_pg.C_scaffold_9000123
MAPTGVYLSFLAAYLLGAPLLLSRLSAQSAISPTIQAVQLLVAFLVGAIGSTWVYRVFLNPLNRVPGPY
*YAARLTNFYIAFRVGKTLQQYRVLERLHR
YGPIVRTGANRVSIVDPDWVEAS
YGHTSVARKGPWYDNNWPNPALQQERDRGAHDLHRKSWAPAFSDKALRQYETHITTFNGKFLLRLA
EHQGGRMNISKCFNLYSFDVMGALAFGKNYGMMDSGEKHAVLSIISTGLDPLGLTLPTWFMHLLQMVPGDPAGITKFFKF
CQNELKEAIINNFYANVETKVSAGSVISSWLAENYKNLPKPWESRPFCLDTQLLIVAGSDTTASALTSLFYYLAQNPNQV
QKLRHELQASAVGDWSDKEIRHCDHLNASITEALRLSLLGPTGLYRATPPEGMQVGEVFLPGNVEYNISQYILARDEAVY
TQAEQFIPERWYSKPELIKHKNPFAPFAMGSFGCIGKNLAMMEMRTLTASILLKYDVSLAPGEDGHRYLEESKEHFTMDL
APLDLVFTPVKS*
>CYP5197A1 Mgr020 Mycosphaerella graminicola
33% to CYP5044A1 (new family)
e_gw.3.299.1 revised
MDSISTSPSVLPFTATWVLAIPFIATLLLTLLRRYLALRTIPGPFLASLTDLWLALRIWRGEYFVDIVSELHKAYGPVVRTGPNRVSFASAEAIPEIYGTSKAASYQPMTLLAKGQEIPTIVTLRDEKRVTEIKRHVSNGFAQSTWLKQEHQIDGTIDILLDQLRKRAGTVISLNKWLSFWGFDTLTMLAFSDMQGHMEAGAEVDKTSAGAKARFD
HWRAWALLPSLEALLYKNRFVQSFQKPSSGLAKLAMKRIEERKASTDEDAPDQDLLGRYLAASKKAPDMIGSRDVMALTISTIHAGSETVAHTSSFALAYALDKMEIFQKLEQEILTAGIRSSPAAYADVEKLPYLDAIIREALRFSASPNTMERTIPPAGAEICGVALPGGTDVSVAKPCTSRDESIFGPHADQFDPERWLHADEQQRREMEHATLAFSFGRRVCIGQHLARIEMKKLIATVVREFK (0)
IQPVNVGIGDWDGNFKKLDLDVKLTPRVR*
>CYP5197A2P Mycosphaerella fijiensis
49% to CYP5197A1 Mycosphaerella graminicola
gw1.17.231.1 revised, missing the N-term about
216 aa
HWRTWSALPWLETLLYKNKYAQTSQKTSNP
LATLAIQRIKEGMSGEKTATGRDLLGRYLAASQQAPNVIAPKDVLALTISTIHAGSESTALFSSFLLIHLLKERQVLANL
ENELQNAKLAVPPAFNDIDKLPYLDAVIHEGLPIQTALSGLSPHDANICGTMIPAGTDVSVSEVLTARDKTLYGLDAGSF
RSERWLHVDKARKAEMDRATFAFAYGRRVCTRQHLAMIEVKKLIASLIMSFT (0)
FEPVDVGIGGYDGALRIMELDVRLAPKNCALLICYEVEIDDDYVEEEG*
>CYP5198A1 Mgr029 Mycosphaerella graminicola
37% to 547B1, top 8 hits are all CYP547 members (new
family related to CYP547)
YSTLIHPEFISPLRHIPKAKYWLPQKLYYQLVLRRTPAEALSQLARETPNNGLLALREPTGVLLLVTKPSVLGELLVARA
ADFEKPTALQGFFKQLTLDGLLTVNGEKHKSLKKRSLSHFNFRAVKNLYPLMWRHALQFAGAVEANFQKIENHQNGTYSG
TVELTHLTTVMTINVIGTTVFGRAFEASDDGSFSQLGKLLQYFLQPSTSTSVYLALTFFSPPWVSKYLTFPLYRAAAGTS
AAMERLCLQIIQKKRLTLKADSKDADLTSLMIQSGHFTDYEIASQLLTYTIAGQETTAATMNWICYLLALDPARQRLLRE
EVSAATELLVDSGIEENIGKTLEGLPFLNGVINEALRLYPTVPLSQRVAVRDTALAGSHVPKGTSIYLSPWLIQRSEEVW
GPEANEFRPERWIRTEDGESKVDPSGGMSSNMDFLTFLHGPRNCIGQNFAKAELRCLTTALTKHFEWALDQPRASVPVSG
LVTINPEGGLSLRVTTVEGTCK
>CYP5199A1 Mgr012 Mycosphaerella graminicola
35% to CYP65G1 (new family)
MSNTDIILTLLKLGFRILVAGIGLSILTLLYNISPFHPLAKYPGPIHWRATRLFASYHHSTGDLYQHIAAFHDRYGHTVRVAPDELSFTDPEAWAQIYNSRPQLPKSTYHFGELSNDRLPTSMITAHDAEHNRLRRLLGPAFQNSSIAEVEPVLQQYFDLLCKQLTIASREGSQDIGEWFLWALNDVIGHLALDQKWECLEKRRLHPWPSYLLNVLKLSAAVNQFRRWGVTMDMLMPFMSAKSRTDAENFIEIAHDAINERLAKEEDEQKSDTDGSSARPDIVGLITREMKGGDKLTKAEVTSNCVLIVGGGAETTATCLSSTMYHLCSTPRVMNKLREEIRAQFSSSEEITLKAVQEMPYLKATIDEALRMFPVASYICPRITPKGGHIVAGEVIPSGFNVTMGQWAMGRSKHLFDNPNEFRPERWVDSEVQDACGRRVNDILKPFSMGPRDCVGKLLALAEARLVTAKLLWHFDMELDGDHSTWVQDARFYVLWQLRPLKVKLTPIRT
>CYP5199A2 Mycosphaerella fijiensis
68% to CYP5199A1 Mycosphaerella graminicola
gw1.8.141.1
MPENSLFEHASLTAPEILGVCLLKILYNISP
FHPLAKYPGPLHWRATRLFASYHHATGDLYKHITAIHEKYGRTVRIAPDELSFSTPEAWPAIYNSRPQLVKTRYHFATDS
SSEVPESMITANDAEHMRLRRLAGPAFLNSGVNEVEPVLQHYCNQLCEELKDASREGSQNMVEWFLWALNDVIGQLALDQ
EFECLKQRRMHPWPAFLLDSLKHTAAVNQFRRFGISMKMLGRIVPQKVIDARDNFLGTAKTAVEKRLAKERDGGAGSESH
FDLKRPDIVGLMLREMKSGDKLTDPEILANSILIVGGGAETTSTCLSATFYHLCKTPRAMQKLKDEIRSTFASADDITLK
AVQQLPYLQATIDEALRIQPVASYITPRVTPKGGHVIDGEMIPGNTYVSMGQWYMGRSEELFDNAKEFRPERWLHSDVQK
ASNRHVDEILKPFSMGPRNCIGKLLALAEARLVTAKLLWHFDMELDGDHATWVDDARFYILWQLQPLKIKLTPVR*
>CYP5200A1 Mgr070 Mycosphaerella graminicola
40% to 596B1, 42% to 596C1, 39% to 68D1, 41% to 68D2
(probably a new family)
MLDIPLLFQIIAGAFLLALIYYKLIDVQRPYPGIPVIELDDQKTKSSRPDPSIFATRETELTAKGLETTNGPFQVFTSAGYKIILPNRFAHELRNNPDMSFTRVGDVDFHAQLPGMEPFRELFKSSNGILRDVVQAKLTQSLGLVTEDLVEEADCAIRPWLGDAKDWSDVEVRTFIYNVVGRVSSRIFGGKELARDEEWLGISTRYTISVNQAVNRLRGFPAILRPIAHRFLPESRNAKAELRAAQRLAEPQVEKRLKIREAAIAAGAPPKSLPDVFSWTMEMAKGRQMFLVETQLALSMAAIHTTTEMVMRCLVASCEHPEIQLPLREEMVKVLRSDGWSMSAFYKMKLLDSFMKECQRYFPLSSMAMGRVAEKAVVLSDGTVLPKNSYSIFIDSGTRDNNIYAHPSTFDAWRYLKMRERPGEENQHQFVSTSVDHLGFGHGVHACPGRFFASNEMKIIVCFLLIEYEWRFGSGQERLPDLKFEGSMIANPATKMQVRKREGEIDV
>CYP5201A1 Mgr060 Mycosphaerella graminicola
38% to CYP657B1 Aspergillus fumigatus
(probably new family)
MAVNATAGSFPTPGLEETLTHPWLSTISQHISATVLVSIVLTIVLTRLFTQFTAPRSISTNNGDPKAVPQVPYWIPLLGHLPDMVISATSFVSNLRDTYTEGAFALNFGGTAHNVFYTPGLATALMNQKTSICNAEDVSRKLMQTVFGYPVNELDKYDAALSEILGAYKFLLSEPHLGEMVDKTARLTKGNISNLVTFMDSPVDQMPWEKVSNIRVLEGQETPTVEADLLQLVRDFCAHTANPSLMGSDFLHQFPDFFSGIWTMDRGFLLLATGLPRWFPIPDLTRAHIARRQNLAALDTFHENLKKHHDGKDVDSKWSSMDDIGALLKARIEIYEKYNFSIRARASAEHALMWASNANSNALVFWMITRIYADRALLAMLREEIAPHVKIALPEKTGLPISEVPRIDAIDVDSLCSKCPLLKSCYIECLRLDSASWSMKVVQKDFVLQSREKDGQSWKLRKGECAHAAHDLHNTDPKYFERPEVFKPDRHVKTEESGERVADMGSIRPYGGGVSMCKGRAFALKESLLFAAAIISMWEFEPADGKKWKIPGHRKATSVYGTNDGTRVLVRRRQFPTTAP
>CYP5201A2 Mycosphaerella fijiensis
61% to CYP5201A1 Mycosphaerella graminicola
estExt_Genewise1.C_50542
MAEGIAQDDRSSVSTSWITYFKANPTIALTLFLAITISITRLTSLTNSTSKTINQDGLKTPPSVPYWLPILGHIPNMALD
ADGFVKKLRSIYRNGIFVVNFGGSRHNIMYTPGLATALLNQKPSNADSEDVGTSLMIKVFGFPPKELDKYHKGLADVAAC
YKHILVEPGLKHMVDRTAQLTKESINNLVTYMESPVDQMPWEKVANVDVIERNGQKMVEANLLELIRDFCAFTANPSIMG
TDFLNNFPDFFDGIWTLDRGFLLLATGLPRWFPIPALTRAHIARKKNVEKCMAYHEQLEKWSKGEPTDTKWTSLHDIGAL
EKARIQVYQKHNWSIRARAATEHALMWAANANSNTLVFWMINRIYADPDLLTNLRSEISPYITIVKDDSASLPITSPPRI
SNIDVDGLVNNCPLLKSTYVECLRVDTASWSLKIVKQDFVLQSREKDSQPWLLRKGDYAHAAHDLHNTDPKFWEDPMVFR
ADRHIKYDEETKKVTADMGSIRPYGGGASMCKGRAFALKESLLFTAAIISMWEIEPAGGEGRKWKIPKHRKATGVYGTDE
VTRVWIKRREV*
>CYP5201B1 Mycosphaerella fijiensis
46% to CYP5201A1 Mycosphaerella
graminicola
estExt_Genewise1Plus.C_130099
MLGPGQSNLSNHHKTFEGATLDKRASFSPTLLLLVAGFAFLLIVRHVGLRKSNNSPLLEKGVVPVPVEPSWLPYLGHPLN
LVWNANSYLNRLRSKYSGGIFSLNLLGTRHHILHTPGLTHTFFAQDEKANVNDVAEHIGIVVFGFPKDEGRKFQEAAGEL
HALGKYLVNEEFLGVMVERTTRRAQENLADFVTGSEDLVEQKPWERRSRVRKTTDKQGHDVFEASLFTLVRDFIANMSCP
SIMGSDFLNNFPDFFDDIWTVDKEFFKLIANLPWWVPFPGMKEGRAARDRIVERLLLFERAMEKRRKGADPGPDWPCLQD
VGHYVQERQNVYEKYGWSLRARAAYEHSLNWAANANSNGLTFWMLNRIYMDKDLLAQLRAEIQPYIRLRAGSGLRGSVDG
QGSSASSGFESLDYNGLIERCALLKSCYIECLRVHTASWSFKMVKEDFSLQARKDSQGWLLRKGDYCHAAHELHNTDPNY
FEDPLEFKPNRHIKYDPEKGYDVADLGTIRPYAGGGSSMCKGRHFAVKEVMIFTAAIISMWDMEAAGGGEWKMPASRKTT
ATHGTDDDCRVWISRRESKEKP*
>CYP5202A1 Mgr053 Mycosphaerella graminicola
37% to CYP52G3 Aspergillus oryzae (new
family?) C-term from JGI model
estExt_Genewise1Plus.C_chr_21393|Mycgr3 N-term from the
genome seq
MWASFYTIIGALVYWFFQRSRVKATHERIVQREGCLPLRCLQHKWYPPF
GLDKLRKVTEAEKIKTYPLLMLGDHERYGDTYAQWGGSVYTVITRDPRNIRAMLSRQFKSFEIGSGRHGCVRPLLGDGIFTQDGSKWEASRKLLAPMIQRPTLPELNLVERHFQLLRNAMTSGLVSDRGPLVSPVAVNMKDLLLDLSLKLTTEFLLGKDLDSKMAPASSTQWTDDFAAEFNVAFKWISKRERLKAFYWLIDSVQFRKSCDVAQRLVDEAVCHAQELRKSRKLSGESYVALDSLLHQEGDHETVRDQFMNLLLAGRDTSGALLCWAFYALSREPQVLIKMRKEIESMVGTDGRAPTKSELNSMTILDQFVTETLRLFPPIPLNGRFSTEDTFLPHGGGEDGEAPILIPKRTLIAFSTFATHRSEDLYGRDASRFNIGRWEDHTKEQRMVDWSYHPFLGGPRKCLGERFAITEAKYLICRALQHFQEI
IPIDEDGNTLAFRSDGAWVDDVKYHVGLTMMPDAGLWLRFVPAF*
>CYP5203A1 P450-16_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
36% to CYP5025A1, 35% to 544A1 in the CYP52
clan
70% to CYP5203A2
RO3G_06009.1 revised
MNSKQSNPLVRYLGGAAATGLLVLSVIYHDRAVFDEHRKDIKTQKGWPLVGNLPLIIQWKDRIHDFLLTGFNQLDEQTLTLSALGIPRHIATLDPQNVEHILKHNFENYIKGPEFHGSMNDLFGNGIFNANGEDWKFQRKTASHIFNVKNFRDHFTDVFIQEIDMMSKHIWDKAVEEHSIVDFHDIMFKFTLDSFILLGFGVQLNALGSIEKVPFAEAFDEAQKNTFQRFVNPIWPVTERLTRFTMPWKKTMRDHLAVVDGFARGVIYQRREEMARGEVHGDLLSRFMQAQKQGAALDTDALRDIVLNFVIAGRDTTAQALSWTFYMLMCHPRVEQRLLEEINQHIKEDINIYESIKNMNYAHAVFYEVLRLYPSVPLNQKFALEDDIWPDGTRIKKGDYVLWCPYAQGRSEKVWKNATEFIPERWIDAEGQLKRESQGQWPAFHAGPRVCLGQNLATLEALVAISLLLKRYKFTLVPQQEITYQVSLTLPMLHGMKVTVQKRN
>CYP5203A2 P450-17_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
70% to CYP5203A1 in the CYP52 clan
RO3G_06495.1 revised
MPRYIGTGITAALTLLTCIYHDRAIFDSKRPDIKTQPGWPLVGNLPVLLQYLMHIHEFLLEGFTRLDSLTLTMSALGIPRHVGTIDPRNVEYILKTKFENYIKGPEFHGSMNDLFGGGIFNANGEEWKYQRKTASIIFNVRNFRDQFTDVFVKELEIMKEKIWDVSADNCQVIDFHEVMYKFTLDSFILLGFGVDLNSLSTQGKVPFAVAFDEAQKNTFLRFVNPFWSVTERIAGLLMPWKTSMNEHLAVVDGFARKVTEKRRAQLAAGEIHTDLLSRFMDARNNKGDPLSNDELRDIVLNFVIAGRDTTAQALSWSFYMLMCHPRVEKKLLEEIDQNIAVDEDLHNSASLYEKIKGMNYAHAIFYEVLRLYPSVPLNQKYALADDIWPDGTHIKKGDYVLWCPYAQGRAEKVWGHDAKQFRPERWLTSEGELRRESQGQWPAFHAGPRVCLGQHLATLEALIAIVFLVKRYKFTLVPNQDITYQVSLTLPMRYGMKVMVEKRV
>CYP5203A3 P450-41_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
70% to CYP5203A4 in the CYP52 clan
RO3G_12103.1 revised
MSIKDTSLRQQIALAGAALSSLVVFLSLKYHDRPLFRKRIEGIPNVKGYPLVGNLPSILKHGERFYDYNVELFESHDTLTLAYPAAGIPETITTIDPQNIEYILKTNFYNYVKGPQAKAFLYDLLGYGIFNANGDKWKYQRKTASHIFNVKNFRDQFTDVFVKEMHVMFDNILEKASIEGTVIDFHDVMFRFTLDSFVYLGFGIQLDTLLNKEKAPFAVSFDFLQRLSAERFIDPLMGIKEGLVNLFCSKEKTTRYNVSRVDSFAQQVIEQRRKEMKEGKTDHKDLLSRFMNATNECGEMLSDRELRDNVLNFIIAGRDTTAQAVSWLFYCISQHPQVEQKMLQEIEKNITDEIERDSPALYEAASEMSYVHAVFYETLRLYPVVSSNQKYAVHDDVLPDGTHVKAGTYVGWLSYAQGRSKRIWGEDAKEFIPERWIDENGKLRREPAAKWSAFHVGPRVCLGQNLATLEALVCIIMILRRYSFKLVENQTITYSLALTLPMKHGLKMTIGKR
>CYP5203A4 P450-21 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
56% to CYP5203A2 in the CYP52 clan, 35% to CYP5025A1
RO3G_07774.1 revised
MSLKDLPVQQKIALTGAAASSLLALITLKYHDRPVFSEHQKDIPHVKGYPLIGNLPTLLHNIPRIYDYQLELFERLDTLTLTAPSAGMPNMIFTIDPRNVEHILKTNFQNYLKGPKFNKNLAELLGHGIFNANGEQWKYQRKTASHIFNVKNFRDQFTDVFVKEMHVMFDNILEKTCKQGTIFDFHDTMFRFTLDSFVYLGFGVQLDALVKEGKVPFAESFDFLQRRSAERFVDPLMGIKETFYNAFLTKENTTKYNIKVIDTFAQDVIEKRRKEIAAGKEDQKDLLSRFMAASNEKGEKLSDKELRDAVLNFIIAGRDTTAQALSWLFYSISLQPRIEKKMLEEIEKYITDEVENDSPALYEVISNMPYIHAVFYETLRLFPSVPTNQKYAFEDDVWPDGTHVKAGTYIAMSSYSQGRCKKLWGENAKEFYPERWIDEEGNVKREPAGKWSAFHAGPRICLGQNLATLEALVCVIMLLRRYSFKLMENQTVTYDVSLTLPMKYGMKMFVEKRK*
>CYP5203A5 P450-43_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
65% to CYP5203A2 in the CYP52 clan
RO3G_14322.1 revised
MPDPIFTHALGLSTALLTALSIKYPDRAIFDEHREGIAYKKGWPLVGQLPAIISNAELMHEFFMNGFNELDSLTTTASAFGIPRSITTIDPRNIEHILKNNFENYVKGPNFNDATKDLLGHGIFNANGEQWKYQRKTASHIFNVKNFKDMFTEVFIKELGIMFSGTFDKAANTGQIIDFHDIMFKYTLDSFILLGFGVQLNALSNKEKVPFAASFDECQLNSFQRFVNPYWKLTEPITAFFQPTKKSTRQHLKTINEFADQVIQKRRKEIANGEIHQRDLLSRFMNTHNEKGELLNNKELRDIILNFVIAGRDTTAQALSWTFYNLLLHPRIEKKLLEEIECYVTDDLMKTPAELYDTIKKMIYAHAVFYEVLRLHPSVPNNQKYALDNDIWPDGTSIKKGDYVIWCPWAQGRSTKVWGSDAHEFKPERWITGKGELRRESQGQWPAFHAGPRVCLGQNLATLEALIAMIFIIKKYKLRLLPNQNITYQVSLTLPMKEGMKVQVEKR
>CYP5203A6 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
73% to CYP5203A2 Rhizopus
oryzae
e_gw1.66.9.1
MSSKKITLPHSVSTYVGGAAVASLAILSAIYHDRAIFDETRKDILTEKGWPLVGSLPALIQGKDRLHDFLVESFYRLDRL
TLTMSALGIPRHIGTIDPANVEHILKHNFENYIKGPEFHSAMNDLFGDGIFNANGEDWKYQRKTASHIFNVKNFRDQFTD
VFVHEIDFMSDNILDKATETSELVDFHDLMYKFTLDSFILLGFGVRLNGLASKEVVPFAESFDIAQKNTFQRFVNPIWKV
TERIQSVVMPWRRSMNYHLNVVDTFAREVTEKRRVQLAKGEIHTDLLSRFMSARNTKGDLLNNTELRDIVLNFVIAGRDT
TAQALSWTLYMLLCHPRVEQKLLNEINENITDKVMHNSPELYETIKNMTYAHAVFYEVLRLYPSVPQNQKFALDNDIWPD
GTHVRKGDYILWSPYAQGRCEKVWGPDAKQFNPERWITPQGDLRRESQGQWPAFHAGPRVCLGQNLATLETLVAITFLIK
RYKFHLAPNQEITYQISLTLPMMNGIKVSVEKRQQ*
>CYP5203A7 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
57% to CYP5203A5 Rhizopus
oryzae
57% to CYP5203A6
estExt_fgeneshPB_pg.C_550057
MDVVSNFISELRNKNLLSSNLGVVSTATIGVLLLLALKYPDRAIFTEHRDGVPHEKGLPLVGHLFGLLKNKYRIHDFQTD
KFVKLDTMTMTMSVLGIPRTIFTIDPRNVEHVLKTNFENYVKSTWFSECTVHLFGHGILNSNGAQWRWQRKAASLIFNVK
NFRDQFTDVFVDEVEILCNEILEKAVVSGEAVDLHEHIFRFTLDSFVYLGFGIQLNSLKTKEEVDFAASFDACQLYSLEK
FMNPMIEYTAIIDRILHPRKKTIKQHIETIDNFSSAVISKRRTELANGGTPNDLLSRFMGAKNEKDEPLSDKELKDISLN
FIIAGRDTTAVALTWVFYCLFNAPEVEKKLLEEITNCIKDEKKMDSAEIYETIKNMTYAHAVFYEVLRLYPPVPNNQKYA
LNDDILPDGTHVLKGDNVAWSPYGSSRNKKIWGPDAANFDPERWITLEGNLRRETQGRWSVFNGGPRVCLGQSFATLEAL
VVIIFLFKRYKFTMLPNQDITYETSLTLPMKNGLRVKVEKRV*
>CYP5203A8 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
63% to CYP5203A6 Phycomyces
blakesleeanus
e_gw1.39.12.1
MPIDLFTDLSFANLLGGSLLLGIGTLACIYNDRAVFDTARKD
MRTLAGWPLVGSTPEIVMGLSRIHDYFISHNKHNELSTATTSAIGIPRHVHTSNPINIEHILKTNFENYIKGPEFHNALA
DVFGGGIFNANGEEWKFQRKTASNIFNIKNFRDHFTDIFVEELDFMVENIWDKAAESHEVIDFQEIMYKFTLDSFIRIGF
GAKINSLGNKSQVPFAVAFDSAQRLVMPRFVNLSWPITEAIQRTLFPWIPTVQTHLKVIDKFAHKVIEERREQLSRGEEH
GDILSRFMTARDLSDKKLGNTELRDVVLNFIIAGRDTTAQALSWTFYMLMCHPRVEKKLLDEINTMVPIEIMHDPVELYK
TVKNMNYAHAVFYEVLRLYPSVPLNQKYALNDDIWPDGTHIRKGDYILWAPYGQGRNEALWGPDAKMFKPERWILDDGRL
NREPSSKWTAFHGGPRACLGQNLATLEALVAIIFLVRRYKFSLSHAQDITYQVSLTLPMKYGMKVSVQRR
>CYP5203A9 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
63% to CYP5203A5 Rhizopus oryzae
fgeneshPB_pg.37__72
MFAVSLKKIMNITHSGNEPADPWFASIGMISSASAIVLGLLALKYPDRAAFYERRKGIYHSRGWPILGATPSMIWNKEVI
HEYFLHQFEKSGVLTSAISSLGIPFTISTIDPRNIEHILKNNFENYVKGPAFDEATQDLLGHGIFNSNGERWKYQRKTAS
HIFNVKNFKDQFTDVFLNGFKIMSEKIFDPAVKENHSVDFHDAMYRFTLDSFILLGFGVHLKTLSTKEKVPFATSFDECQ
RNAIRRLTNPAWRIGETVRHCLAPWKKTIPQHVETINSFASDVIKNRRDQVAKGEEHGDLLSRFMKCRNEKGNLLDDTEL
RDTVLNFVIAGRDTTAQSLSWTFYNLMQNPAIEEKLLEEIREHITDSMEDDPPAMYEAIKHMTYAHAVFHETLRLHPSVP
NNQKYALNDDIWPDGTHIQKGDYVVWSPWAQGRCVSVWGEDAKIFKPERWITPEGDLRRESQGQWPAFHGGPRVCLGQNL
ATLQALIVIVFLLKRYKLSLVPGQEITYLVSLTLPMKNGMSVMVEKRQPAQ*
>CYP5203A10 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
79% to CYP5203A7 Phycomyces blakesleeanus
estExt_fgeneshPB_pg.C_310060
MEVVARFVADLRKKNILSSNLSVASTAAIGVLILLALRYPDRAIFTEHREGVPHDKGLPLVGQLFSLLKNKYRIHDFQAE
KFVKLDTMTMTMSVLGLPRGVMTIDPRNVEHVLKTNFENYVKSNWFNYCTEHLLGHGIFNANGAQWRWQRKAASLIFNVK
NFRDQFTDVFIDEIEILCSETLDKAVVSGDAVDIHDHMFRFTLDSFVYLGFGVQLNALKTKGEVTFAASFDACQLYSFEK
FMNPLIEFTSVIDRILHPRKKTMKQHIATVDQFAADVISKRRTELANGEVHTDLLSRFMSAKNENDEPLNDKELRDVVLN
FIIAGRDTTAQALSWTFYCLANAPEVEEKLFKEIKDYIKDEKKMDSTELYETIKNMTYSHAVFYEVLRLYPSVPNNQKYA
INDDVLPDGTKIRKGDTVSWSPYGTARSKNVWGLDAASFNPERWITPEGDLRRESQGKWSVFHGGPRVCLGQNLATLEAL
VAIIFLVKRYKFTMLPNQNITYETSLTHPMKNGLKVKVEKRA
>CYP5203A11 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
60% to CYP5203A6 Phycomyces blakesleeanus
estExt_Genewise1Plus.C_310065
MEGVLSLVENSNINILQNIGLVGGAAIAISLLAIAYPDRPVFTGIRSGIVYRAGAPIIGHLLE
LLKNKFQIHDFEIDFFQEIGTLTG (2)
AMPSLGLPFSIATIDPQNIEYILKTNFTNYVKGPHFGYATEHLLGHGIFNADGEQWRWQRKVASHIFNVKNFRDQFTDVFV
SKIDTMCESIFDKSIEEDLPIDFHDAMFRFTLDSFILLGFGVDLKALTTQGEVPFAVSFDKSQQYSFDRFTNPFIGITNT
FRSIFRPWEKSIQQHVQTIDDFASNVINQRREELARGEMPTDLLSRFMGAKNENGKDLSKTELRDIVLNFIIAGRDTTAQ
ALSWTFYNLALHPRVEEKLLREINEKIGNEKEHDAQQLYEIVKTMTYAHAVFHETLRLYPSVPENQKYALEDDIWPDGTP
VCKGDYVGWSPYAQARSTAVWGPDASCFNPERWITPEGELRRESQGQWPVFHGGPRVCLGQNLATLEALIAIAFLLKRYR
LSLLPGQVITYQTSLTLPMKNGMLVRVSKRQ
>CYP5204A1 P450-2 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
26% to 512G2,
26% to 512B1, 27% to 512G1, 24% to 54A1
possibly in
CYP54 clan
RO3G_00859.1 revised at C-term
MTHNKYLTLSAVAAATFLLWKLLPKNSDKSNLPPLVKGSLPFLGHLLQLQHNPREFIQHAKDKYGPCFRLKLPGQGTLVVVTGELIPEVMKATKDFNFPKGVENLVPTSRIVELSYGHKFIPEKISPRAKNPVTYPIKHNFKEHQIDIFSKRIQTALKRGIGEVLSIPKGEKRTVNMLETLSYVVSCISCPCFAVSHIGHDKEFIKGMAAFTRKIIRAGIALTLLPGWLGRFLLRSYFSVEHEMDLIMTRLVPELEKVRAGAEIEPTFATMSLNVPKEDGTLRPVADVAYHFKDIALASIHTTSHFATLSLHELACRPELMQALRDELKTLHGDLTPENVATLTLMDSFLREVFRCNADYLGLHHLTMRDTLLSSGHIVPEGAMVVLALDQAHHDPTYIQSADLNTFDPYRFTKENISLKSTTIGLNHLSFGIGAHACPGRYFAVNEIKYMIAELITRYDVSTKTGKRAKDFVLLGMTKFPPNEPLIFCNKEDDI*
>CYP5204B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
47% to CYP5204A1 Rhizopus oryzae
fgeneshPB_pg.1__581
MQRIQDQIDAHYWIITNGQSWIKPVTAITLGIVLYKLFSPAPDPRKTTTIDPKLIPELVAYPLPIIGHVPTLSKGRNNFL
KECVDRYGPVFQLRIPGQNPYVVTGDIIPDIMKSSTKIVSFLEGIKTLIPATHVMELSYDHKYKAAPFNSRDKNPAIYPI
KQNFKSDKIHVFSERIQTGLHIVLKRDLDLKPGESKSVNMWDFLTNTVSQMSCPCFAGSVVGYDSELISSMAVLTQKIIR
AGIFLAVLPSWLGDAIVRRVFSVEKEIDITMRLLVPELTRTREEILNGTSEVTFSSMLLSLPLHDGSLRSIEETAFWFKS
IALSSIHTTSHISSFCLHELSCRPELVETLRNEINRLDSLNPETTATIPLLDSFLREVLRCNIDYLGHHSLALQDVQLRN
GQIIPKGSLIMSALLLAHEQGISGQATQDNHTKTCLPLDQFDAYRFVDAGEDTNATDVNLANLAFGLGAHACPGRYFAAN
EIKYMLSELIMRFNLSTPSGKRGENSVLLGTSVFPPKTPIVFTAI*
>CYP5205A1 P450-27 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
33% to CYP505A15 A. niger, 31% to CYP505D6 in
the CYP505 clan
RO3G_10498.1
MSTENLTTLIVALKNATNIEKEGCIIQFGNGANLDTIRALAAEKLNITDGYANIRLLNSKGELFDGIDKVRNQQIVYVDTKTKIQETIPGPMKLPFVGNLYDMVPNLIEGWIRQFEKYGPVVEISLLGKILVGTNSPAVAEVFARESEYFTKKITKSGLGEVKEFAGQGLFTTDTDEMDWQLAHKLLMPAFSPRAIKAYQVEMAIIAQQTVKVFEQFKPHEPVEIIEWTTNLTFETIGRIGFGYNFNLLVGRGQEQNPFIEAMGYCLSLALKRMQQAQFVKQLPIEANRRFDRSVRLMHEIVENVIRERKESPDATNKEKDLLGYMLNARDEHNLGLSDDNIRDQVVTFLIAGHDTTANTLAWALYELAKHPEVQAKVLQEIADNHITHEKAPTPEQISNLKYMHQVFKEVLRKYPPVRNLSKYCKKDCILPGGYKIKAGTPCTVQVYAMHHNKDVYPDPERFDPDRWIPEEEQKRSRFAWLPFSTGPRACIGMAFALQEAKTVLSMLLHRFDFRHDGPNVRWDPKMATTKPLDLFMTIHPRENFPEPNGKAASKKSATMTERDGKQTAMPVISDNIGTKVELPPITFLYGTQTGTAQDYATILSEQARSFGFTQVTLCEMDRWNVLADGKFISNDDDDKKLDKQLVVICTATYNGQPPDNAENFDKFLDKKMRETDHENIFTGLSYAVFGLGNKNWRTYQRFPNKINQCLSEFGAERFFTSGEGDSDKDMDATFNDWCARFWSHLLGTYGIAASESNSVVPSAAAAKESIVKVKFIQPSNKEAWEKAANDFYGSPNAVILANKELQKDGSPRSTRHIEIDISKLLGVGEQGHLYHAGDHLEVMPENSKVIVEAIALKFGWVLDSVFEIDQETLLNVSPRSVASNVKGPCTIRNMLTYYADVTSPPSRAVLGYFATQLKLTAPETASEFEKLIMPDSNNQDQYPNFIKQHRTLLDLISAYPQVNRLDLGQFLAAVPVIQPRRYSIACSPLVYPQHAHLTVGVVDDVINDRHYPGLCSSFLKGAYDLSIRATLKSCKNTFSLPQDPSTPLIMISAGTGLAPFRGFLQERKAQIDILGQDKVASSVLFFGCRRADQDYIYEEELEAYSKNGVLSKLYAVFSRNLEKSPIKYVQHQILANAAQVWNMLYPTDNNTKPAAVYICGSGAMSRDVRRTFYNLAVSFGVAATEEEAEALILKLIDEKRYNEDVWG*
>CYP5205A2 P450-50 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
79% to P450-27 in CYP505 clan
RO3G_17132.1
MSTDNTTSLIVVLRNTSDVEKDGRIIRFGNGANLDTIRSLAAEKLAITGGYANIQLFNSNGELLGGIDDLRQQQVVYVDIKELIRETVPGPTKLPFVGSLYEMLPNIAEGWMRQFDRFGPLVEISLLGKIIVGTNDPNIAEIFAKESEYFTKKITKSGLGEVKEFAGQGLFTTDTDEMDWQLAHKLLMPAFSPRAIKAYQGEMGIIAQQTMKIFEQYRPDEPVEILDWTTNLTFETIGRIGFGYEFNLLVDRDQEQNAFIEAMGYCLKQAVQRIQQAAFVKQLPIEANRRFDRSVRLMHEVVENVIRERKASPDAKNKEKDLLGFMLNACDEHNLGLSDENIRDQVVTFLIAGHDTTANTLAWTLYELSRHPDIQAKVLQEIADNHIRHDELPNTEQINNLKYMHQVLKEVLRKYPPVRVLSKYCKNDCILPGGYKIKGNTPCSIQVYAMHHNKDVYPDPERFDPDRWTPEEEQKRSRFAWLPFSTGPRGCIGMAFALQEAKTVLAMFLNRFDFKYNGPDVQWDFKTATTKPVDLFMTIHPRENFPKPNGDSVPPQKSDASSNQAESKTATAMPVISAQKNADVELPPITFLYGTQTGTAQDYATVLASQAKGFGFKNTTLCEMDKWKVLADGKFISDNKDKKKLDKELVVICTATYNGQPPDSAEKFDSFLDNKMREDDHENILTGLSYAVFGLGNKNWRTYQHFPIKVSQCLSELGAERLFASGEGDNDKDMDAAFNDWCARFWSHLLEIHGIAACESKPVVPTAAIKESSVDIKFVQPSDKEAWNSAINNHYGNPNAIIVANSELQKDQSPRSTRHIEVDISKLSGVGEQGQLYSAGDHLEVMPENSKASVESIALSFGWILDSVFEINQETLSDVSPRSLAANIKGPCTIRNMLTYYADVTSPPSRAVLGCFAAQLKLVAPETASEFEKLIMPDANNQDQYPDFIKQYRTLLDLIHAYPQVNRLDLRQFLAAVPVIQPRRYSIASSPLSYPKHAHLAVGVVDDVVNNRHYPGLSSSFLKGAHELPIRAILKSSKSTFSLPQDLATPLIMISAGTGFAPFRGFLQERKAQIDNLGADKVAPSVLFFGCRRADQDYIYQEELETYAKNGVLSDLHVAFSRSDDKSPIRYVQHQILANAAKIWNLLYPAADDNSRPAAIYICGSGAMSRDVRRTFYSMAISFGAATNDKEAEALIIKLMDEKRYNEDVWG
>CYP5205A3 Phycomyces blakesleeanus (Zygomycete
fungus, Mucoromycotina)
60% to CYP5205A2 Rhizopus oryzae
e_gw1.15.208.1 short model
fgeneshPB_pg.15__173
(best model)
in the CYP505
clan
MVVNTTSIIVAIKGANDLEEDGYIIQIGNGASVETVRNLAAEKLHLVGPTADIVLEDMEGNPLNEIDKIR
SQKVVYLNPKDTIKTVIPGPTKLPYIGNLYEMMPDMNAAFLRFFEKYGPVVDVNIIGNRVIATCDPEVAE
LFVKENEYFTKKIKAALKEIKLFAGQGLFTTDTSDPDWKLAHKLLMPAFSPRAIKVYQKEMGIIAQDTIR
IFEQYKPDEKVDILHWTTNLTFETIGKIGFGYEFGLLEKREAPPHPFIEAMAYCLKQSIARFLQAQFIKS
LPLEMNRRYDREVKLMHTIVDEVIKERKQSKDANDIEKDLLGFMLNARDEHHQGLSDENIRDQVVTFLIA
GHDTTANTLAWFLYEISRQPDIEAKILQEIANVGITHTDLPCSEQISKLKYIHMCLKETLRMHPPVRALG
KYCQQDCIIPGGYKIEAGTSVSVQLYGLHMNPKVYPDPYRFDPERWTPEEEQKRSKAAWLPFSTGPRACI
GMAFALQEAKTVIAMLLNRFKFCYDGPPVKYDPKQPTTKPVDLFMTIHDRTDFPESSINPEAYKPKESTG
LAKKMPKLSQSIEMATLKLPPITFLYGTQTGTSQDYASVLSNQARQFGFKNITLTDMDKWKVLKAGRYEG
PTGVNEDRELVVVCTATYNGMPPDNAEKFDKFLDKSDTQGNEKILHGLQYAVFGIGNKNWRTYQHFPIKV
DSRLDDLGADRFFISGKGDTDGDIDSDFNEWSAHFWSHTLSHYGLAISKDTSIVPSSSVNNEATQAAVVH
YVSPKDTEKWELGFNNRNGTHNAIVIENKELQQGDSGRSTRDIRIDVSKLNPVGDNDLLYLPGDHLEVMP
ENDPDIVEAVALGFGMILDSVFEIDQSSIVGLSPRSLAATIKGTCTIRNALTCYADLLSPPSRRILGYFA
AQLHKIAPETAKVFDSLTMPDVNNKDQYPEFTKKYRTLLDLQRGFPQVQKIEIGQFMAAVGVMQPRRYSI
ASSPHLFPKEAHLAVGVVDDVVNGKHYPGLASSFLAHQVPGESKAVLRANFKSSKGVFEMPPDAETPIIM
ISAGTGIAPFRGFLQERAYQHKHASGPVGECLVFFGCRREDQDRIYGDEFDEYVKEGVISGLHVAYSRQI
PPSARKYVQHQVLANANEIWRMMVPLDKSKKPAVVYICGSGAMSRDVRTTFRSMAISFGAAKDEEEADKF
IQKLIQSRQYNEDVWG*
>CYP5205A4 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
88% to CYP5205A3 Phycomyces blakesleeanus
e_gw1.15.206.1 short model
fgeneshPB_pg.15__167
(best model)
in the CYP505
clan
MSTNLTSLIVAVKGAQDLEEEGYIIQIGNGASVDTVRNLAAEKLDIVGSTANIVLEDAEGNTLDEIDRIR
SQKVVYLNTKDSIKSVIPGPTKLPYIGNLYEMMPDMNAGFLRFFEKYGPLIDVSILGTRMVATCDPDIAE
VFVKESEYFTKKIKTTLKEIKLFAGQGLFTTDTSDPDWKLAHKLLMPAFSPRAIKVYQNEMGIIAQETIR
ILEQYKPDEKVEILHWTTNLTFETIGKIGFGYEFGLLEKREAPPHPFIEAMGYCLKQSIVRFSQAQFMKS
LPLEMNRRYDREVNLMHSIVDKVIKDRKESEDATDIEKDLLGFMLNARDEHHQGLSDENIRDQVVTFLIA
GHDTTANTLAWFLYEISRQPEIEAKVLQEIANVGITHTELPSSEQISRLKYISMCLKETLRMHPPVRMLG
KYCQKDCILPGGYKIEADTPSVVHLYGLHMNPKVYPDPYNFDPERWTPEEEQKRSKAAWLPFSTGPRGCI
GMAFALQEAKTVIGMFLHRFKFCYDGPAVKYDPKQPTTKPVDLFMTIQNRTDFPEPSADAEVYEPKEASG
PTKEMPKLDRSIEMASVKLPPITFLYGSQTGTSQDYASVLSNQARQFGFKDVTLTDMDKWKVLDSGKYEG
PTGVNEDRELVVVCTATYNGMPPDNAERFDKFLDKSDAQGNERLLHGLQYAVFGIGNKNWRTYQYFPIKV
DSRLDDLGAERFFLSGKGDTDGDIDSDFNDWSAHFWSHTLSHYGLVISKDISVVPSSSTNKEASQAAVVH
YISPSDTEKWDLGFNNRNGTHNAIVIENKELQQGDSGRSTRDIRIDVTKLESVGDNDLLYLPGDHLEVMP
ENDPETVEAVALGFGMVLDSVFEIDQSSIVGLSPRSLAATIKGPCTIRNALTCYADLLSPPSRRILGYFA
AQLHKIAPETAEVFDSLTMPDVNNKDQYPEFIKKYRTLLDLQKGFPQVQKIEIGQFMAAVGVMQPRRYSI
ASSPHMFPKEAHLAVGVVDDVVNGKHYPGLASSFLAHQIPGESKTVLRAKFKSSKGVFEMPADAETPMIM
ISAGTGISPFRGFLQERAYQYKHASGPVGECLVFFGCRREDQDRIYGDEFDEYVKEGVISGLHVAYSRQI
PPSNRKYVQHQVLANANEIWRLLVPADETKKPAVVYICGSGAMSRDVRATFRSMAISFGAAKDEEEADKF
IQKLMQDHQYNEDVWG*
>CYP5206A1 P450-3 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
27% to CYP5148A2, 28% to CYP5050A1, 28% to
CYP5046A2
24% to CYP504C1, in the CYP64 clan
60% to P450-38, 60% to P450-19, 60% to
P450-18_var1,
53% to P450-48, 49% to P450-47, 56% to P450-5
cyan YSKGIVVGSYLFKNLSR is missing from closely
related EST EC997850.1 (remove)
added green seq
RO3G_00866.1 revised
MNFSKQNISNMGVGILKQNTYILLPACAALLSCYYLLTKEISIEKKGNKEIPYPPQAIKLPIFSLGSTPAKQITKWHKETGPIYKINVGTQLWILISDPNLAHDVFVKAGSSTSSRPYHRFNVDIYGKNNR(2?)
GIAFSQYGPEWKNKRKA (1)
VASLLSSSSIDKFCDLAEAEA
DSLMNRLIKVSQKGEMVSIDKQAELMSMNVVLTMGVGIRYDDINDPKFQMLINFPSDASTLVGAAGDIGSFFPYFGWIDMFMGTEKKLQKFVKQFRDDVYNKLIQDALKREEDTLVKSMYKMKKEGLIDEDDILVFMSDFIAAGTETLATTLYWSFAILSQKPDVQSRIVAELDMWKSKNPLGAVPHFHQDRDEFPYAICVQKEIMRFRPVLNFGLPHMASEDVVVNDYFIPKGAVLISSMAAMHENPDVYDDPEVFKPERFMMNTKRMGAAANAKIEDRDHFGFGWGRRICPGIHLVSIRTQKEKLFFVLISKTLLLRQKWSCSIFTFVSFPSSRLSLKSIHMVIPSMLI
>CYP5206A2 P450-23 Rhizopus oryzae
94% to P450-3 with some variations in the
CYP64 clan
RO3G_08351.1 revised
MDVGILKQNTYILLPVCAALLSCNLLLNWLFIVGHIFSLGSTPAKQITKWHKETGPIYKINIGTQLWILISDPNLAHDVFVKAGSSTSSRPYHRFSVDIYGKNNRHSKGIVVSSYLFNNLSRGIAFSQYGPEWKNKRKAEAEADSLMDRLIKASQKGDMVSIDKQAELMSMNVVLTMGVGI
C
AAGDIGSFFLYFGWIDMFMGTEKKLQKFVKQFHDDVYNKFIQDALNREEVTLVKSMYKMKKEGLIDEDDILVFMSDFIAAGTETLATTLYWSFAILSQKPDVQSRIVAELDIWKFKNPLGGVPYFHQDRDEFPYAICVQKEIMQFRLVLNFGLPHMASEDVVVNDYFIPKGAVLISSMAAMHENPDVYDDPEVFKPERFMMNTKRMGAAANAKIEDRDHFGFGWGRRICPGIHLAEMELFNFCVCFFPKFKIEHEIGSHGNPIYVDLNCSEELGVTNKPVPCKFRITSHNL*
>CYP5206A3 P450-18_var1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
83% to P450-5, but P450-5 has an insert before
I-helix
RO3G_06830.1 revised
MDTNKLKETAFIIVPASAALLSIAYLSRKGKSEEKKGLIEIPFPPNATNLPIFGHMFGLGKCPSKQITQWHKEICPIYKLRMGNQLWFMISDPLLAHDIFVKAGSSTSSRPYHRFLIEIYSKNNRGISMAQTNHLWKNKRKAATTILSPGSVDKFSDILEAEVDQLVDRFAKYSESGEALDPFKELQLSSLNVILALVLATRFESTDTPDFKTMHRCINDIMIFGGPAGDIGSFLPMLAWIDMFTGVENKMRNFVNIYRDDFFMKLIDNALKKNQRSLVKDLYQMKEEGLIDEDDILVFTSDLIGAGADTVATTIYWAFAILSQMPEVQSKLMEELDEWKSKHAPGAIPSFNKDRDDLPYSICVQKEIMRFRPATNFGVVHMASEDVIVNKYFIPKDTILVSSMAAMHKNPEFYEDPDEFKPERFLNNTNRMGAASNAKIEDRDHFGFGWGRRICPGIHLAEKELFNFFVRFFSKFTIETELDSQGQNVKLNLDDYVEEGIMCKPLPCKYRIISRKV*
>CYP5206A4 P450-5 EST = EE007880.1 in CYP64 clan Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
59% to C-term part of P450-3, 54% if yellow is
deleted (missing in EST EE008707.1 from P450-38
remove MQNRNLIFCEPNTILFQSG it is intron seq
not found in EST EE007880.1
83% to CYP5206A3
RO3G_01667.1 revised
MDINKWKENAFIIIPASAALLSIIYLSKRARSDEKKGIIEVPFPHNATNWPIFGHMLGLGKSPSKQITRWHKETGPIYKLRMGNQLWFMISDPLLAHEIFVKAGSSTSSRPYHRFLIEMYSRHNR
GLVLAQTNHLWKNKRKAATTILSPGSVDKFSDVLEAEVEQLIDRFAKYSESGEALDPFKELQLTSLNVVLTLVLATRFESVDTPDFKTMHRAINDVMIFAGPAGDIGSFLPMLTWTDLLTGIESKMRDSIKIYRDGLFTKLIKNALEKEQHSLVKDLYQMKEEGLIDDDDVLVFTS
()
DLVIAGADTVATTLYWTFAILSQMPEVQTKLARELDQWKSKHTPGAIPRFNQDRDDLPYSVCVQKEVMRFRPATNFGVVHMASEDVTVSGYLIPKGTILISSMAAMHKNPDFYKDPDEFIPERFLNNTNRMGAAANTKIEDRDHFGFGWGRRICPGIHLVNAEKEVFNFFVRFFSKFTIETELDSQGQHVKLDLDGCVEEGIMCKPLPCKYRIIPRKT
>CYP5206A5 P450-19 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
77% to P450-18_var1 in CYP64 clan
RO3G_06895.1
MDIKKLKDNASIIIPASAALFSILYLSRREKVEEKKGFKEIPFPPNTTNLPIFGHIFALGSCPSKQVTKWHEEMGPIYKIYMGNQLWVMISDPFLAHDIFVKAGSSTSSRPYHRFLIDIYGKNNRGIVFAQNDILWKNKRKAVTSILSPGSVDKFSDVLEIEIECLIDRFAKYSQAEETIDPFKEIQLSAMNVPLKLALATRFETTDNPTFKKLHKAIDKGMVYGGPAGDISSYLPSLAWTDTFTGMEKKMRDFIHHYRDLIYGKLISDALKSEQHSLVKDLYQMKEEGLIDEDDITVFMSDLVGAGADTVATTIYWSFAILSQMPEVQAKLTKELDEWKSKHASGAIPRFNEDRESLPYSVCVQKEIMRFRPATNFGIPHMASEDVTVNGYFIPKGTILISSMAAMHKNPNFYEDPNEFKPERFMTNINRMGAAANTKIEERDHFGFGWGRRICPGIHLAEKELFNFFVRFFSKFTIETELDSQGQNVKLNLDDYIEEGIVCKPLPCKYRIVPRGA
>CYP5206A6 P450-38 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
61% to P450-18_var1 in CYP64 clan
RO3G_11042.1 revised
MDAEKLKQNAHVLIPACLAVLSSLYLLNKSKLNEKKGLKEIPYPSNSISWPLFGHLLSLGDVPSKQITQWHKTTGPIYKLNMGNQLWIMISDPFLAHDIFVKAGSSTSSRPYHRFTTDLYNMNDKGLVFTAYNNKWKSKRKTAIALLSPGSVDKFTDVLEVEADSLMERFGKIAQNGTLIDPFDQLQLTSMNIILTVMAATRFDDVDHPDFVAINKYLYHAMIYAGAAGDLGSFLPSLAWTDVLTGTEKKLRKLLEEQRDPVYKKIIKNAGGSEKSSLVKDMFKMKDEGDLNDDEILVLFSDLLAAGADTVAVSLYWAFAILSQKPDVQTKIIEELDAWKAKNPPGAVPSFHKDREEFPYSICVQKEVIRFRPVTNFGIPHMTSEDVIVNDYFIPKNAILISSMCPMHANADVYENPDQFIPERFMKNTNRMGAAANTKIEDRDHFAFGWGRRICPGIHLAEIEIFNFFVRFFSKFTMAPELDSQGNPIPIDLDDYVDEGIIMKPVHYKVRIVHRT
>CYP5206A7 P450-47 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
52% to P450-38 in CYP64 clan added green at
I-helix intron boundary
RO3G_16665.1 revised
MILKKRKTHTGQYPINTVLLSPPTSTQDKLLSLLSKNCPSRKVTQWHKENGPIFKINMGNQLWIMISDPLLAHEFFVKAGSSTSSRSYHRFNVDIYGRHGRGLSFAQYTPKWKTVRKIAVSLFAPESLRNYINILEAESNNLMDRLRDMSGDGKAFDCYQHLSLESLNFVLRVTAATRLESVEDPTFQSISNLSHYTLIYSGVSGDLVSYTPSLAWIDRLKGTREKMQAFINNQRDPIILKLIEEAMKKEDDSLIKELYEMKEKGALDEDDIYVFMT
()
DMVIAGSDPITIALYWTLAILSQQPKVQEKLIKELDAWKAKNSADAVPHFYQDIDQFPYMLCVQKEVQRFRPGTIFGLPHMTTDDVTAQGYFVPKGSMLFSSMWAMHQNKAFYGDPDRFRPERYMDGLKKISAAANARIEERDHFGFGWGRRICPGIHLSEVQFFNFYVRFFSKFTVVPDLDSEGNLMPVDLNHIVEEGIVSKPMPYKIRILPRT
>CYP5206A8 P450-48 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
92% to P450-47 in CYP64 clan added green at
I-helix intron boundary
52% to P450-38
RO3G_16678.1 revised
MDLDRLKQNTPLLLPACLALLSTLYLLKNSRSAKEKEGMKEIPYPHGSISWPIFGHMLSLRNCPSSKVTQWHNENGPIFKINMGNQLWIMISDPLLAHEFFVKAGSSTSSRPYHRFNVDIYGRHGRGLSFAQYTPKWKTVRKTAVSLFAPESLRNYINILEAEADNLMDRLRDMSGDGKAFDCYQHLSLASLNFVLRVTAATRLESIEDPTFQSISNLSHYALIYSGVAGDLVSYTPSLAWIDRWRDTRDKMQALINNQRDPIISKLIEDAMKKEDDSLIKELYKMKEKGSMDEDDIYVFMT
()
DIIIAGSDPITVALYWTLAILSQQPKVQETLIKELDAWKAKNSADAVPHFYQDIDQFPYMLCVQKEVQRFRPGTTFGLPHMTTDDVTAQGYFVPKGSMLFSSMWAMHQNKAFYEDPDRFRPERYMDGLKKISAAANARIQERDHFGFGWGRRICPGIHLAEVQFFNFYVRFFSKFTVVPDLDSEGNLMPVDLNHVVEEGIVFKPMPHKIRILPRT
>CYP5206B1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
39% to CYP5206A6 Rhizopus oryzae
gw1.3.485.1 revised
joined with fgeneshPB_pg.3__834 = N-term part
aa boundary between TDII and YLAD
MEKISKCIFESEYAFTVSKAIVASVAIKLAY
ILYSVFCKSQNDTDSWNREGFKEIPSPPEKYPYF (1)
GHILSLGNMPSLQVEKWHKEH (1)
GPIIHLNMGTAHWVFINNPQIAHEVLVKKGAVTSERHNHKFAYNMYSKNGS
(2)
GIVFNRTGKKWKNSRNI (1)
ANSILSPQNINRITGGLEQSIDSSLETLKEESQKNEPVCLLPYLELIT
YGVIIKAVFGKDVASIDDPLLKKFIYISRGVMEHSGPKGNIASVLPGFSWISRLTSVEKD
MHAVVNIRDVSVKELLNDAVSGETDCLVKHAFSVKKENNLSDTDII
(0)
YLADLIVGAGDTTASLLLWLFAILAEYQDVQKIICAEIDTFMMKHGRIPSFSDRLDL
PYTEAALLESARFRCVSNFGVPHCVTEDGN (2)
TVQIDEYCIPKNTLVVISMYAMHMNPDVYENPHKFMPERFFGRTNSWNTSSNGSIKDRDIYMFGWGR
(2)
RICPGIHL (0)
TEIEVFTVCIRFLARCSIEPPIGKDGKPETIDLHELLGGGITFTPKEYKVMFIPRNDSLPI*
>CYP5206C1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
46% to CYP5206B1 Phycomyces blakesleeanus
fgeneshPB_pg.10__160
MSSTLIQSLYNEENLLHITGFVAVGVAAKLVHTILVWANQGKGEDPWNREGFKKIPVPSGKYPYF
(1)
GHVISMGKVPAFQVEKWHQESGPIIHITLGIQHWVIISDPFIAHELFSRNGIRASGRQRHFFTHEIYTDGGNRGILFND
TGKKWKNARGMALSILSPKFVNRFTAVIEDMADDTLRTLKETSDKEGAVWPMPLLKLGTFSAITRSLFGKTAESLGEETF
RTIAFLGEEVIRLAGPENDIDSFFPKFSWLTKLSSEKKAMENVVTKRDIIYRKLIKDAVEGDVDCLAKNAYALKDEYNLS
DMDLIIIMSDLFAAGGDPIALSIAWLYAILPHYPEIQKKMCDEIDQFIVKYGRIPSFSDREELPYVIAVMMENIRYRSIT
NFGIPHYATADIEFLEYFIPKGTVIMNSMHAMHMNPTVYEDAQKFMPERFLGCLKSWTTLSNGNIKDREMYAFGWGRRTC
PGSHFAEVEIFNMSVRTLARYTVEPALNTDGTPYYYDLDVVSTGLNLPPKEFRVRFVTRVDAPMIIPS*
>CYP5206C2 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
75% to
CYP5206C1
gw1.1.533.1
MNSELIQSLYSEENILPVAGVIAAGVAAKLVHTLLVWAKKE
KNEDPWNKKGFKKISVPSGKYPYF (1)
GHSLTMTDNPTYKVEEWHQEC (1)
GPIIHLTLGVQHWVIVSDPYIAHELLSRNGVKASGRQRHYFTHEVYTDGGK
(2)
RGVLFNNPGKKWKNSRGI (1)
ALSILSPKYVDRFTSVIEEMADDTVKVLKAASDKEGGVFPTPLLKLGTFSAITRSLFGK
TSEELGEETFKTIIFTAEELIRLAGPENDMASFFPHFSWIANCFAEKSSMINVVNNRDKI
YKKLIKDAIEGDVDCLAKSAYALKDEYGLSDIDLIVIM (1)
SDLFTAGGDPIALSLSWLFAVLPHHPEIQKRMCEEIDAFIIKHGRIPSFSDREEIPYIIAVMMENLRFRSITNFGIPHYATDD
IEFLGYFVPKGTVIMNSMHSMHMNPEVYENPYQFMPERFLGSLRSWTTLSRGSIEERDMYAFGWGR (2)
RTCPGSHF (0)
AEVEIFNLTVRTLARYTVEPTLNPDGTPHLYDWDVVYTGLNLPAKEYKVRFVTRTDTPVDIPL*
>CYP5206D1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
51% to CYP5206C1
Phycomyces blakesleeanus
estExt_Genewise1.C_260073
MENSLVDYISKNNYVKTAAKAAAVSLTASLVYYAIKEPKEDNWNRKDFKKIPGPSGYPFVGHMLSMGFTPSFQIEKWHEQ
YGPIVHINMGAQQWVIFNDPVLAHDLFVRNATKASDRRRHKFTNGMYSKGGRGIAFSQPGKKLKHTRAIALSILSPKYVD
RYLGVLENIASCTVELMKQETDRDGSVFPMPFIQMATFSAMIKSIFARPLHLDNDPVVKEIIYIMENELKFAGPAGDLGS
FFPNFAWANSLFQKKKKMEALVARRDELYKMLIKDALNSEEDCLVKQAYQMKEEYGLDDNDLIVMMSDMTSAGGDTTAIS
LSWLFAVLPHHPAVQKKICDEIDRFFAKFNRLPTFSDRDEFPYMCAVLRENIRFRSVTTFGIPHFTSEDIELQGYFIPKG
TVVACSMYAMHMNPDVYHDPKQFIPERFMGHTKTWSASANGPIDERDMYSFGWGRRICPGIYFAEVEEFNLCIHTLSRYT
VEPALDSDGYPVYPDLKHASSTSVVFAPAKYNVRLVEREDSPLKKQT
>CYP5206E1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
48% to CYP5206C1 Phycomyces blakesleeanus
fgeneshPB_pg.53__1
MDRSWFMNSFRENAMISVTGFIAVGLASKLVYEVFNWNYKAFLNKDEWNKKGFKKIPVPPKKYLYFGHMLSLSEDPTAQV
NQWLKTYGPILHLTMGVQHWVVIADPLLASEIFVRNASKSSGRQRHIFTHTIYADGAKGLSFTDSGKKWQKSRKIAQSML
SPERIEKFSGVIESITDNVVDELAKASNRDGSVCPLSFVKLSTFSIMLKSLFGKTVDSIDDPLLQDVICIADGIVKYISP
EQDIGSFIPSFSWITKFSKQRKGMANVVKLRNVVLPKLVSEAAHGEVDCLVKQAYALKEEYGLDDDDLVSMMSDLLAAGG
DPTSVSLTWLLLILAQYKDVQQRVCYEIDAFVEQNGRLPSFSDRENVPYIRAVLLECIRFRSITNFGIPRFVTEDIECLG
YFIPKNTVVMTSMHAMHMYPNNQTDADQFIPERFLGRTKTWAANSRANVQERDMYVFGWGRRICVGIHLVEVEVFNMCVR
ALGRYNIEIPMRQDGLVDDIISKGSVSRGLNCMPHDYTLKFIKRCNTPLDAHATKKD*
>CYP5206F1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
42% to
CYP5206D1
estExt_fgeneshPB_pg.C_180202
MSIQQNFPTINYRHISPIVAASAVAASVCYFLFSKNTSHKGLNNIPSPKRNYPIFGHMFSLGKVPAEQIDEWHKELGPII
QLQVGSQVWVVVSNPHLAHELFTLRGSVTSARPSHFYFMDIYSRGGKGVVFVSATKSWKMARATAMGLLSFASVKRLSGV
FQKEADIMVDYMLKSTKKDGSVDSLKNLQLVAFNVIMSTCFGKRYNSIEDPEVVSMFAFINQHNIYARIEDDPGSFFPYL
SWILNLSNKKRKMDQFVRANRDKLFYELIKEARNGTSDCFVKSLYETDAKHSLNDLDIMIMMSDIVIAGSETTAVAMSWL
IAVTLNYPEIQTKIQAEIDAFTSEYGRLPEFSEAHKLPYLCSTQKESLRYRSITTFGLPHEASEDIDFKGYHIPKGAMLI
VSMKTLHMNSDKYKDPEKFIPERFMDKYTTISSAANGPILERDQYNFGWGRRICPGIHLAEMEMFEVFIRLFSSCDISPA
LDTNGNPIKVDLEGFRDYGLVDAPLPYGFRITERVYFEALFPKFISDVHFYSQ*
>CYP5206G1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
48% to CYP5206B1 Phycomyces blakesleeanus
estExt_fgeneshPB_pg.C_210147
MNIQLFLIKFGEESNKPIKNLVLTSLTITLVYTICSTIYKKYAKGNDPWNRKGFKKIPSPPERYPYIGHMYSLGDSPSTK
LDKWHVKHGPILHLYMGIQHWIFVSDPVIAHELMTRHGSVTSDRSNHTFAFEMFSKNGS
(2)
GISFNKYGKKW
KDSRSAVLSILSVPYFDAVAGTIESVADNACGHLKKITENEGSVDPLEYIQMATYHTMIKAVLGKDVRSIDDTVLKDIIW
ITHKLLRYASPEGDIESFLPKFSWFREQTQLKKDMKSFVELRDKVYTDLIKEAVANNTECWITRAHARKSEYNLNDNDLI
VIASDLVSGGGENPCTSLMWLFAALSQYPDIHKRVCAEIDNFVTENGRIPNFLDRLDLPYTCALLKENLRFRNTSNFGIP
HRVTKDIEALGYFIPKDSLIVSSMHAMHMNSSVYNNPYEYMPERFLGHTKTWAAESYGKIDERFLFNFGWGRRICPGPYL
AEMTIFIVAVRILAQFHIEPTVDVNGKPEFVDLNSFSNKGFTFAPTEYKVKFVPRSNNNLPKDSV*
>CYP5206H1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
45% to CYP5206D1 Phycomyces blakesleeanus
estExt_fgeneshPB_pg.C_180113
MDKIDFQHLLSEKYMISTIGVIVFSMVVKAVYTLFKNRKNESTINQIRGETFHEIPSPKAGYPYVGQMFSMGDNPGAQIE
KWHRELGPVIRIKMGVQSWVLINDPLIAHDVFMRNGAKTSRRPIHSFTTGLYSKGGRGVSFNQPGKRWRSTRAVATTVLA
QKSIDKYTEFFEAIADKTVDRLISVSKKDGSVVPFPHFQLASFGVIIKLAVGKSVKSLDDPVFTKLLEMSDKTMMYGGIV
GDLGSFLPALKWINMFSSVHKDMVKMVESRDKNIAKLVNEAIEGENECLAQQMNILKAEYGLVDQDINVLFSDMITAGGD
TIAVALYWLFALLLQYSDVMKKMRDEIDSFIIEHKRIPRFSDRSELKYNIAVHRESLRFRAVTPFGLSHCATDDVISNGY
FIPKDTVILAGTDALHMNEKYFVEPKKFNPDRYIGIEKTMSASNNGPAEERDTYVFGWGRRICPGIYMAESEIFNLCTRI
LARCNVEPALNKDGTPAYPNLDKVVTMGIVSLPVEYKVRFVPRTDSPLDF*
>CYP5206J1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
46% to CYP5206F1 Phycomyces blakesleeanus
fgeneshPB_pg.2__921
MPEFSLPSLSNEHFTLAAVAAAAAATLTATAFYAFSETKDPNLKHLKEIPEPKEKYPYIGHLISLGNRPGKQVTKWHNEL
GPIFKLRMGIQTWIMVSDPYIAHELFSTRGSLASSRPAHGYLRDICSAGGCGLIFAETSKKWHRTRSAAMALLSPKSVDP
IGQDMIEEADKLTKALIEGTAKHGCMSPSEDLYLVSYNVIMTVCFGLRAESVEDPDFKAMIDYIHQHGMYSGLSGDVGSF
LPILSLAAYISGIKKKQIDFVKVTRDQMFSRLMEKGINGEKDCFAKSLYEGKDKYGLDHQDILVLLGDIIFAGTDTTALT
TTWLLAILSNYPDVQRKIQAEIDDFVAKNGRLP
LYSDRESFPYLAATQKEGLRLRSITEFGVPHEASEDINLRGYHVPKN
AILIGSLDAMHTDPLRYANPEKFIPERFLGYPESMSTLASGSIKKRDQYNFGWGRRLCPGIYMAETEMFYNLTRIFHRCN
MEPPLDVDGNPIIVNIDKFVDHGITSSPVPYKMRFIPRSEALF*
>CYP5206J2 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
85% to CYP5206J1 Phycomyces blakesleeanus
estExt_Genewise1Plus.C_100002
MPDFSLSSLRNENINLAVVAAAATAAVAATLTATAFYSFSETKDPNLKNLKEIPEPKEKYPFI
(1)
GHLISLGNRPGKQVTKWHNEL (1)
GPIFKLRMGAQTWIMVSDPYLAHELFFTRGSLASSRPAHGYLRDIYSAGGC
(2)
GLTFTVTSKKWHRSRSA (1)
AMALLAPKSVDPLGQDMIEEADKLTKSLLEDTAKHGSVSPSDGLYLVSYNVIMTVCFGLR
TESSDDPDFRSMVHYIHQHEIYGGVSGDVGSFLPILSLAAYISGTKKKQIDFVKKNRDEV
FSKLMEKGINGDKDCFVKSLHEDKAKYGLEHQDILVLL (1)
SDIIVAGTDTTALTTTWLLAIIANRPDIQRKIQAEIDDFVAKNGRLP
MYSDRESFPYLAATQKEGLRLRPITEFGVPHEASEDIDLRGYHVPKNSILIGSMDAMHTNPLRYARPEEFIPERFLSYPE
SMATLASGSIKKRDQYNFGWGRRLCPGIYMAETEMFYNMTRIFHRCNMEPPLDVDGKPIIVDIDAFIDHGITSSPVPYKM
RFVPRSEALF
>CYP5206K1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
47% to CYP5206C1 Phycomyces blakesleeanus
estExt_Genewise1Plus.C_10687
MDKKWLEVLQKEEHYLPLVGVVTVGLAARLVFALFSNICQNRKESERLKLEGYKEIPSPSGRYPFFGHMLSLGKAPSFKV
QKWHQQLGPIIRLDMGVQPWVLINDPYLAHELFVRNGINSSDRHKHSYAYWMYSKGGKGMIFNQPGKKWKSTRSAALSIL
APKNADQITESSVSITDNAIKLLKEDTDKEGAISPVRYMKMATYGTVFKAVFGKDVTSINDPTLNSLIHITERSIVYAGA
AGDIGAFFPSLSWINHLSSQKKAMNDIINERDKVLEVLIREAKDGDVKCLTKVAYSIKEELGLDEMDLTILLNDVFGAGG
DTTGMSLTWLFGILPQYPDVQKKICDEVDEFLVKYGSLPSFSSRDEFPYTTAVLRENLRFRSITNFGIPHFTANDVNISG
YHIPKDTILISSMHAMHMNSSIYEDPEKFIPERFLGTTKTWSASSSGSIKERDIYAFGWGR
(2)
RICPGIHL (0)
AEMIVFNMCVRVLAQCTIEAPLDANGKPEFVDLNNIKTQGIIFGPQDYKVKFIKRDSSPFYHQL*
>CYP5206L1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
44% to CYP5206D1 Phycomyces blakesleeanus
fgeneshPB_pg.6__211
also e_gw1.6.253.1 (join)
MEHSRLRISVKEKLVNPLRRAVTAGVLGACLYKSYSLILENQENTSVWDRRGFKKIPSPSERYFYIGHFLSFREQPNIQL
QKWHKKYGPLIHLNMGAQHWIMISDPYIAHEIFVKNGAKTSGRHEHSFSYEKYAKAGSGIIFSHPGKKLNSALANAMRIL
SHQNVDQCIEEFEFTAETTLAQMMEATEREGSVDPSIYLKLGAYNTLIKAIFGRNISSINDPVFKDLLQVTQNVLQCSSP
HRDIKSLFPRLAWLECLIGNNKKKEKIVSSRDELYGRLLKEALDGDADCLAKEIYLLKEEQELEEKDLIVMLSK
(1)
CDLIVAGETASTYMMWFFAIISQYTDIQKKMCEEIDKFISDTGRIPGFSDRDLL
PYLCCVLKENGRFRSPSNFGIPHTVNAD (1)
IRVSGYFIPKGTILMASMHAMHANEEVYTDPSRFLPERFNKSNKMWNTSTNGPIKERETYIFGWGR
(2)
RTCPAIYF (0)
TEVEIFNMCVRTLARCSIEPEFDKEGNPMLVDLNLSNSLGLGSVPVPFKVRLVPR
TKFIFATTNFTT*
>CYP5206M1P Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
47% to CYP5206K1 Phycomyces blakesleeanus
region in yellow does not match well and
requires a frameshift
possible pseudogene
gw1.15.127.1 revised
MSHRLLKIKDSNHIIPIFGVVMLGLAAKYVYRLYSSSKQKQRLNDPWYKEGFKDIPSPSEKYPYI (1)
GHMLSLGDNPSFQLEKLHQEL (1)
GPIFRLQMGTQRWVLLSDPLLAHDLFVRNGINTSGRHPQKFSYKMYSKGGR
(2)
GIVFSQPDKKWKNSRTV (1)
(?) MIFIYFKKKALMVLSSKFVDPLQKSIEDIAE &
HSREHGSVNPLLSLQMTTFNTILRAVFGKTTQSPDDPFIRQIIRDTEKGNLLVGSSGNLTS
FLPGLSWIEDLYHGNTREKLIEHRDQDLKKLIADAVDGDVDCLAKQMMTFKDEYGLDD
QDMLVIL (1)
SDLISAGEDTTSLSMSWLFGILPHYPDIQRKMCAEIDAIVTKYGRMPVFSDREEMPYIVAVLRENLRFRSSVNFSIPRYSTDD
IEFHEYFIPKDTVLITSMYTMHMRPENFSEPEKFIPERFLDDMRTWSASANGAIEDRDMYAFGWGR
(2)
RVCPGIYL (0)
AEVEIFNVMVRTLSRHTIEPGLDSFGNLVYCSMDTLDTHGITFGPKDFTIRLVERKDSSLNYSS*
>CYP5206N1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
48% to CYP5206K1 Phycomyces blakesleeanus
e_gw1.25.82.1
MDNYLIEIISRKDYISLSIAAAAVGLAAKYSYNIYSNSRQNYINKDGFKNIPSPPGSYPYI
(1)
GHMLTLNICPGEQVKRWHEEL (1)
GPIISLKMGAQPWVCISDQNIAHEIFVRNGVKSVNRPNHDFGYQVYSRGGK
(2)
GLIFGSTDKAWKNARAA (1)
AQIILSPKYVDKFQSALVSTVDTVFKLMREEAEINGSVNPAKYFYMTTYSSILTAVFGKTVQS
LDDPNLKDITFFVDHSNKYVTPIGALGSYLPHFEWIYRFTQHKAQMNAIVEVRDKLFTKL
LHEAVSGDIDCLAKKLFMLKEEYNLDEMDLIILT (1)
GDLIGAGGETSGTSLTWLLAILSNYPEMQKKISDEIDSVIEKEGRIPTFSDRADMPFTTAV
LRENIRFRSCTNFGLPHYLEDDVEVFGYLIPKGTTLMTSMHAIHMNPDIYDEPEKFKPERFLNFTK
TWSAAANGGIKERDMFAFGWGR
(2)
RVCPGIYF (0)
AEMEIFNMCVRIFSQCTVEPPYGLNGELKSVDMETIYSGGIIAAPLEYKIRFVTRANSLANTLKKSN*
>CYP5206P1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
52% to CYP5206C1 Phycomyces blakesleeanus
e_gw1.6.211.1
MYNALLPNVSAEKCALPLAGAIALGMAANITYKIFMWAQQKLKTQDFWCHPDYQKIPSPSKKYPYF
(1)
GHMLSLKDTPGLQLQTWHRNL (1)
GPIIRLNMGVQHWVIINDPTIAHELFSRNGIKTSDRQKHKFTYDMYSKGGR
(2)
GIPFNKTSKKWKNARNI (1)
AISILSPKYVESFTKVLDTIIDKAIKQLEDETEKNGSVSPMHSLKVVTFSAMLRS
LLGGSAKFIASETLDDIIKTTEVMFTYSGPEGDIDSFVPQLAWINKRSKHREEAEAIINH
RDSLYKRLIQDALEGDQDCLLKHIYSLRDEYELDETDLLVMT (1)
SDLISAGGDPTALSLAWLFAILSQNPGVQMKMQSEIDSFVARNGRTPGFSDREELPYTISVLLENIRFRSVTNFGVPHLTTQDVEF
LGFFIPKDTVVISSMHAMHMNENVYENADKFIPDRFSGSRKTWSISSNGSFEERDMYAFGWGR
(2)
RICPGIHF (0)
AEVETFSVCVRTLARCNIEPIIGLDGKPEYVDLDSILPAGLNFSPKEYKVKFIKRG*
>CYP5207A1 P450-4_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
56% to P450-20b, 55% to P450-37_var1, 52% to
P450-35_var1,
47% to P450-9
35-36% to P450-3, 30% to CYP5050A1, 29% to
CYP5069A1
28% to CYP665A1, in the CYP64 clan
RO3G_01533.1 revised
MDLQKLIEKLDRKQTTTILSSAILTVAATWFILKRRNKKRESTGIKEIPTPEGEYFYFGHLPLLISNPSAQITEWHRKLGPIFRIKMGVQNWMFISHPVLAHDIFVTRGTSTSGRPYVTFGNGVHGEGNRGVIFADYGKSWKNTRTAVLNILSPKSVDTLQPILERETALGVKLMMQQEEISPLSYTRLMGLNVAIATIFGLHGAQSTTDPIYREVIGNMENTFEFVGATRDIQSFLPAFAFVDFLLKSKKKMVNFVNNQSRPLYRRLIKMARENKQPCLINKLDEIKESLGIDEQNILVLT
(1)
NELVVASVDTTSLAMAWTMALLCRYPEHQKKVIENLDMFVQSQNRLPLFEDRHQLPYLVAFIKESLRYRSSAHIGLPHKVTEDIVYGDYVIPKDTILFNNGHSSNHDPDFFTDPHLFQPERYLNDTRSIYASSNSAIQQRELFSFGWGRRICPGIYLAENELFNLLVRLLSQCTVEPILVDGKKVYPDLDTFVDGGGTVSPTDYKIRLVPKV
>CYP5207A2 P450-20b Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
56% to P450-4_var1 in the CYP64 clan
RO3G_06941.1
MDIQALIQKLDKKQTTLLSTAILTVATTWLIRRAIKKSKEFKTLGAKEIPTPKGEYFYLGHLPLLGKYPSLKVTEWHRELGPIFRIKAGVQNWVFIGDPEAAHEIFVSKGSISSGRPYLTYGNGIHGEGHRGIAFIDYDKSWKNARTASLNMLSPKSIDGLHEAIERETEYGVNLLITESHKQGSINPVDYTRLTAINFVLSTVFGIKGIQHIEDPLYKEIVHTMERHVENISAVGDISAYLPILSFLDVIFRKERNLKKFVEKEHRPLYRRLTKMARESDQPNLVKKLDEIKDSLDIDEENIVILG
(1)
IEMMIGGVDTVSNALAFVLAVLCHYPEWQKKMSEEIDAFVEKYGRLPYYTEREELPVVVAVLKETIRYRPSAYLGIPHKATEDIVYKDYVIPKGTVLISNNHTTNNDPNFFPEPEKFKPERYLGDVRSIYASSNGAIQSRENFSFGWGRRICPGIYLAENEMFNWMCRLLRKCTIEPITSSTGEKIYPELDDYIDLGAIVTPVPYKVHLAERTNV*
>CYP5207A3 P450-35_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
66% to P450-20b in the CYP64 clan 29% to
CYP5069A1
RO3G_10904.1 revised
MDYQTIIKKIDRKSITILSSAVMAVVVTWMIKRAIKKSKEPKTAGLKDIPTPKGEYFYIGHLPLFGKYPSFKVTEWHRELGPLFRIKMGVQDWVFIGDPEMAHELFMSKGSVTSGRPFFTYGTGYHGEGERGIVFTDYGKPWKNTRTAALDVLSPNTVDILQETIARETGNGVELMIKDAFEAQEKNESINPLAYTRLTAMSIILATVFGIDGAKSVEDPLYKRIISGMEENAHYISLVGDLSAYFPVLSFLDVLFRKERKMKNFVENSSRPLYRHLVQLARLSDRPSLVKNLDEIKDSLKIDEQNIVALT
(1)
NELMIGGIDTVSNSMAWAFAILCHHPDWQKKMSDEIDSFVHKHGRLPMFTERKEIPSLIAVIKETLRYRPSIYFGVPHKATKDVVYKDYVIPKGTILISNAHTTNNDPRLFSEPEKFKPERYLDDPKSLYASSNGSIQNRELFTFGWGRRICPGIYMAESEMFNWMAQFFQRCTIEPFISSTGEKIYPNLDDCVDKASTIAPLPYKVRLIKRHDTQL
>CYP5207A4 P450-37_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
69% to P450-35_var1, yellow is an insertion YKIEKMTNERTRAINIKQT
in the CYP64 clan 29% to CYP5069A1
RO3G_11021.1 revised
MVYIIIVKDLFYCWIISWWHVKRTIKKSKEFTTSGLKDIPSPEGEHFYLGHLPLLGKYPAFKVTEWHRSLGPIFRIKIGVQNWVFVGEPEAAHDIFTTKGSLTSGRPYVTYGYKFHGEGNS
(2)
GIVFTDYGKNWKNTRTAALSILSPKSVDDLYHILDRETKFGVNLMLKDALEVQDKEGGIDPLAYTRLTAMNIILATVFGIQGSLSVQDPLYKRVLHNLEQNSAFISIGSDISAYFPVLSFLDVIFRKEKKMRDFVENDSKPLYRHLIQLARQSEQPSLVKELDSIKDSLNIDEQNMVTLT
(1)
NELMIGGVDTISLAMAWVFAILCHYPKWQKRMLDEVDLFIQNYSRLPLFTERQELPSMIAFIKETIRYRPSFLLGVPHKATEDIIYKDYLIPKGTLLIGSAHANNNDPHFFSEPEKFKPERYLNDAKSIYASSNGNIQSRELFTFGWGRRICPGIYMAESEMFNCMTRLFQKCTIEPALSSTGETNIPDIDDCIDFGSIVSPVPYKIRLVERNSVVIDE
>CYP5207B1 P450-9 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
~45% to P450-4 with a gap in seq, Seq 4 is
longer here
in CYP64 clan
RO3G_04485.1 revised
MDYYRELLKVDRPERYTTLLGAAVATVATALFVKSVVNKSKEYKSPGGREIPSPKGDYFYLGHLPLLGKRPGLTITKWHQELGPIFRIKVGSQNWVFVGDVEAAHELLVSKGSATAGRPEMTYLTKVHSPGER
(2?)
GVIFVDYGKKWKEARNAILNILSPKS
VESLSHILDREAQQVVDIMRDQAKVNEEVDPHLFTRLAGMNLMLAIAYGVPGAKSVEEPDFKKVEYFSTMAMRFSSPSEDFSVIFPSLKFLDVILRKEKRMIDFRDKEFFPYVRNTIKLARESKEDSLVKKMDEIRKEYGLDEQSILCLL
(1)
SETLTAGTDTTSVGTAWAIGILCHHPEVQKKLCDEIDAFIRKHGRQPAFSDREELPYFIAFEKECLRFRAPTDLGLPHKVLKDVVYKDYIIPKGHIIYVNVHTLHNDPQVFPEPEKFMPERFLNDTRSMYASSNGAIQNRDHFAFGWGRRICPGIYLAESQIFHLLTKILATSTIEPAISSTGEKIYPDLDNVIDTGITVGPVPFKIRLVERMDRVLA*
>CYP5208A1 P450-44 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
35% to CYP5046A1, 32% to CYP5046A2 in the
CYP64 clan
RO3G_15771.1 revised
MSFSNLTALVVLASTATCYILWRNKRSDIDSLLPPRAPGYIPIIGHILELIRPIPIHELFYKWSLQVGPVFTCHFGTQKWIVINSIEAVRDLIVERGTIYSSRNLPDTIIEDIFQGDIDKGGSFAFMTYGPRWRHLRRIDSGLIKNKIDLYQPILNERRTALLSYIYKLSEEKNEKDKGIDISYFIEHYTMTSILTIAFGDICSFEPEDPTLHKAFNLTERASKALSPGDQIREFFPILQILWPAEKARYFQLRDDIVKFYETLLNRFKAQKSTQDCFVKEIMKENELNDLQIIYFI
ALFVGAGSDTTASTIEWTIAYLANHPEVQDLAYNEIKEEVGLDRLPQSYDEPNLPFVQCIILETLRIRPPAPTAIPHATSEDDVYKGWHIPKNAVILMNLFAIHNNPLRFPNPSQFQPERHLEYVQESLRHHKFSQVIEDRPHLGFSTGRRVCVGIHLAERKLFMAISMLLACFKIERISEDLIDVNTHKDIHGVTWAIPHYKIQLVPRHDKV
>CYP5208B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
49% to CYP5208A1 Rhizopus oryzae
fgeneshPB_pg.1__894
MESLYLHSSFPWATTKLSLFGTIVSAVALGTILYLVNPGKPRDTATQNLPPSAPNRLPILGHLLFFVKPDYLPELFRQWS
FIVGPVYTVYLGRKRWVILNSAAAVKDLIVDRGSIYSSRDLPDIMVNTLMNGVDKGGGFAFFPYGKQWRNLRRIAHSGLI
LKKIDLYQPILNDRRKVLLGNISRAIDDTKAISLTKYIEHFAMTNILTIAFADLCSFEPGDPKLHEVFSITERSATLLGP
SEQLVEFFPILKYILPNHIKKFQDLRQEILDFYGDLLREFKARLKKDPSKVKDCF
MKEILAMDVLTDIQCMYFIALFVGA
GSETITSTLEWMLVLLANNPEFQDRAFAEIEQNVGLDRLPTAEDEHKLPFIQCIIHETLRIRSPAPISVPHSTSKDDVYN
GSFIPEGTTVVINVHAIHLEESKYPDAKKFLPDRHMDYVLDNEKKLFSSQSVEGRPHIGFSAGRRACVGIHLAERTLFTV
AAGILACFRIERETDELLNDYTPKDNRAATFAPTPYKVRLVHRHKGVSNLV*
>CYP5208C1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
46% to CYP5208B1 Rhizopus oryzae
estExt_Genewise1Plus.C_60392
MDLQQKLTNDTVIAGVVGTVGAYLTYKLYKTISQPSEGNMPPIAPGRQPFVGHLLQMNQPIPPQKVF
SKWAKEVGPVYTVHMGTKRWIILNNTESVRDLIVNRGAIYSSRDLSPLLVDILFHG
(1)
VENGGGLPFFPYGKEWRYLRRL (1)
THASLLKRKVDSYQHILEDRRLDFLKNLEEANKAGAEEGFCMNTQIEHLAMTTVLSIVY
GGELCYYDTNNPDLHAIYAQTSESTAVLQPSEQIREFLPIFSFLIPSRVKQYEGLVKRTD
TFHGNLLKQFKEKMAKNPDNVENCF
MKDMLTENSDITDLRLSDLAMVFVAAGSDTTSGTLQWLVAALANHPEVQDRAYADILENVGKDRLPGPEDEENLPYIKGI
LFETLRLHPPAPLSVPHCTTEDDVYGDWIIPKGTTIVMNLDSIHRDPTRYPQPDKFLPERHLEFIKNSKNQTSQSVEDRP
HLSFSSGRRMCVGIHLAERSLFTTATGLLATYRIERVSEELIDVSIQRDIYGVTSNPVPHNVRLVRRVPIA*
>CYP5209A1 P450-6 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
24% to CYP5093A2, poor match to all P450s
25% to CYP504A5, 25% to 620B1 yellow region
too long VSLMKEDKTGKK remove as intron
possible 64 clan
RO3G_03451.1 revised
MASVLSYIISMFITYVVTQLGQRFMWKNKKQDGTPKMPWPASPRGLPYLTKAYNIFQKESYHALTRWSKQVGDLFSVEIGFKRVIVMNSPELVQKFLIEKEQYNSSRSPSDTFESTLTDRAKTIYSAPFSSYWARLRRAVHVVIGKDHHLQFEQTFKSQSETLSFCIGESLKEECKLTAKELRQLVDLIAADTALTMVIGPEKRKPQTLLELVTKCRELEALQTSKYNRLGQFFPAFNSLVDVYRLFVMDSSITKARNALLDIFMPSFETIYSQKEQIEESKKKEGYVPYSKVSTIAKSLISIDPSKNDPEPVQLTKEEILINITHMTVHAQTYLASTLFSLIQRAAGEPKWQTMILEADEEEQISLAKAFVKECLRLDAPNKLIAYTPRTDYDFEAPDGYMYRIDTDTELVMNVDAIHKNTRYYPNPQEFAPERFMKSEKKM
(0)
VANDHMAFGAGRRVCLGSKASEEMLTVTLLHLIKTYMLEGGNVDNKIEIGTSLWSWTGRTETQGGSISFTRRQ
>CYP5209B1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
42% to CYP5209A1
estExt_fgeneshPB_pg.C_20032
MGSAVSILSATAFSWLISQLMTGVLWDGKNQDGTPKNPWAPSPSNQPYIWNAYDEVAERQYRAFTDWAKELGALISVKIG
QKRMVVLNSGSLVQESFVRLEQNNSARSIRDGVEVLMTDSGKTVFAAPFEIYWVRIRRAIAIIIGAAYIAKFDGLFSAQA
AKLSQGIQFEKSSKNGKPIDAEHLRQLVNLIAMDTSLAIVVGQTNTDPATMLLISEKCREIEAIQANKWYQYGHFINIIQ
STYSFLALMRKSLTAIAQRNDLLEVFLEWTSPFIANRGDQTVEVRTIAESLLTILPSKNDPEPAQLTADQVIVNLIHITL
HSYKNLSSALFTLIQRLASLPELQERIYAEVLSVKDKEGTLDDWPLIGALINESMRFEPPMRMYSHTSRVEHDILDGEDK
PFRIDDGTEIIANLDAIHFDEQYYAEPHTFNPDRFLVKEKKS
(0)
FMPARDHLAFGAGRRKCQGAKASERMLAATVARLVKSYKLEGGDANVKVDYHSNIWSWTGRTETKGDEIKFISR*
>CYP5210A1 P450-1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
33% to many different families CYP5070A1,
CYP617D2, CYP547B2
new family in the CYP56 clan
RO3G_00211.1
MNEETLKIIRKNVINYLEKWKSSEKLDATLAAKLGLSSVAAYFLYKTVLYRLYLHPANKIPGPRVGWIPFMGNFFQILKADNDQSPFIKWAEQYGGIFTVHFYWNEPRVVVSDDRLVKQILTSQMYDFEKPMAASKMLSRIVGNGLLVAEGHAHRVQRKMLNPAFSIQSIRAMVPLMIGPCYTLRDQWIQMISTNHTEYTEIEVSRDLSLATLDIIGITAFGQDFGSVAHYGTDKMNRLSKAYLKLFSRGMSLIRILTIAFPVLGLLPTKENREDAEMLRWLKEESEALVEAGLQRDAEEKKSGKTSQYQDLLALMVNLIDKDTGKGFTKEELRHQCLTFLAAGHETTSNTLCWCLWLLAQHQDIQDKLRSEILVLFKDNKILDYNAVNALPYLDHVCCETLRLIPTVPQTARVSRMPVVLGPYVLPKNTIFYIPSVVSHHSKEIWGEDVNEFKPSRWEKTDHIGNAYEYFPFLAGGRQCIGQRFAIVELKILLSILIRDIQFFEKPGFKVQKSQFIVTRPTPNMTLWTKRVSY*
>CYP5210A2 P450-11 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
90% to P450-1
This seq has a frameshift near the PERF motif,
in CYP56 clan
RO3G_04957.1 revised
MNEETLKIIRNNVINYLEKWKSSEKLDATLAAKLGLSSVAAYFLYKTVLYRLYLHPANKIPGPRVDWIPFMGNFFQILKANTDQSPFIKWAEQYGGIFTVHFYWNEPRVVVSDAKLVKQILTSQMYDFEKAASKSKILLKLAGNGLLVAEGHAHRAQRKMLNPAFSIQSIRAMVPLMIGPCYTLRDQWIQMISNNHTEYTEIEVSRGLSLATLDIIGITAFGQDFGSLAHYGTGKMNRLSKAYFKLFSQGMSLMSFLTLAFPVLGLLPTKENRENAEMLRWLKEESEALVEAGLQRHAEEKKSGKASQYQDLLALMVNLIDKDTGKGLTKEELRHQCLTFLAAGHETTSNTLCWCLWLLAQHQDIQDKLRSEILVLFKDNKISDYNAVNALPYLDHVCCETLRLIPTVPHPVRVSRMPVVLGPYVLPKNTFFYIPPAISHHSKEIWG
&
EDVNEFKPSRWENMDHMVS
AYEYFPFLAGGRQCIGQKFAIVELKILLSILIRDIQFFEKPGFKVQKRPLIVTRPVPNMTLWTKRVSY
>CYP5210A3 P450-13 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
73% to P450-1 in the CYP56 clan
RO3G_05127.1
RO3G_05134.1
MNQETLQIVQKNITNYVEKWKSSEKLDAVWAAKLGLSSVAAYFLYKTIIYRLYIHPANRLPGPRVSWIPFMGNFFEIIRTEDDQSPLRKWAKTYGSIYTIHTQLNKPEIVVTDEKLVKQILTTQVYDFEKPDIVSRELERLTGRGVLVVEGQAHRIQRKMLNPAFSVQSIRAMVPLMLGPGYTLRDQWLHKISESNTEYTEIEVSKSLSLATLDVIGITAFGQDFKSLSYYGTEKMNRLSKAYLSIFSNEMATMQILSIVFPILRYLPTKRNREEAKMLRWIKEESAALVEAGIQRDQEEKRSGKINQSKDLLALMVNLIDEDTGKGFTKEELRDQCLTFLAAGHETTSNTLCWCLWLLAQNQDIQDKLRAEILPLFKDGKISNYDAVNAIPYLDYVCRETLRLIPTVPDTNRINRVPVVLGSYVIPKDTTFHIPPVVSQRSKEIWGEDADEFNPSRWEKSENIGNAYQYFPFLAGGHQCIGHKFATVEMKVLLSILIKDIQFFEKPGFKVQKKQIITMRPIPNMTLWIKPVSSS*
>CYP5210A4 P450-14 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
100% to P450-13
RO3G_05127.1
RO3G_05134.1
MNQETLQIVQKNITNYVEKWKSSEKLDAVWAAKLGLSSVAAYFLYKTIIYRLYIHPANRLPGPRVSWIPFMGNFFEIIRTEDDQSPLRKWAKTYGSIYTIHTQLNKPEIVVTDEKLVKQILTTQVYDFEKPDIVSRELERLTGRGVLVVEGQAHRIQRKMLNPAFSVQSIRAMVPLMLGPGYTLRDQWLHKISESNTEYTEIEVSKSLSLATLDVIGITAFGQDFKSLSYYGTEKMNRLSKAYLSIFSNEMATMQILSIVFPILRYLPTKRNREEAKMLRWIKEESAALVEAGIQRDQEEKRSGKINQSKDLLALMVNLIDEDTGKGFTKEELRDQCLTFLAAGHETTSNTLCWCLWLLAQNQDIQDKLRAEILPLFKDGKISNYDAVNAIPYLDYVCRETLRLIPTVPDTNRINRVPVVLGSYVIPKDTTFHIPPVVSQRSKEIWGEDADEFNPSRWEKSENIGNAYQYFPFLAGGHQCIGHKFATVEMKVLLSILIKDIQFFEKPGFKVQKKQIITMRPIPNMTLWIKPVSSS*
>CYP5210A5 P450-26 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
60% to P450-13, 59% to P450-1, in the CYP56
clan, 34% to CYP5070A1
RO3G_10122.1
MNQSIQSIVDKVVPSLNLIQDKVNEYVEKYLARSPPSQKTVVLGLSSAVSIYCLSKYIIYNLYLHPLRHIPGPPADWIPPFGNFREIVRSESGAPHKRWAEKYGGMVLYHGEWNQPRVIVTDHKLLKQVLTTQEYDFIKTPATAKFLKRFLGNGLLVAEGEVHRFQRKILNPAFSVQSIRSMVPLMAKPGLRLRDLWLETIKSSGKEFTEIEVSSGLSLATLDVIGLAGFGQDLKSLEHVGTEKQSKLSQAYLHIFSNDLSLMRILTLLFPALRFLPTERNRKTRRDLRWLEEESKALVQAGIERAAVEKEDGKPKDLLALMVNLIDDETGKGLTAEELRNQCLTFLAAGHETTSVSLSWCLWLLAQNQKIQDSLRKEVKTLFTSDDIPTYEEINALPLLTNVCRETLRLIPPVPVTSRITRAPVVLGSYALPKGTILFLSLIVNHHSKEIWGEDAEEFNPYRWETEKIGNAYQYLPFLAGGRQCIGYKFALIEMKLLLALLIKDIQYFEKPGFKVIKKQQLTLRPAPNMTLWMKAA
>CYP5210A6 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
56% to CYP5210A5 Rhizopus oryzae
e_gw1.4.106.1
MQQSIEAFKAIRLQDTLQATHQHWNVLLGLAEKYINQKVLSPLGINASVQRVLTGVGLASYFGYI
ISKYFIYRLYLNPVNKIPGPPVSWFPFTGNAIEIIKLE (0)
SGAPHKI
WKDKYGGIISYHGPWNSPRVLVTDAKLLKSILTTNEYDYIKAPQTSDFLRKFIGNGLLVAEGQEHRKQRKMLNPAFSVNT
IRYMVPMMAIPGVHLYKKWQKALKETDALEANVSHELSLATLDVIAIAGFGEEFEAVKLADTPERNKLGEAYMLIFSPEK
SIMRFLSFFFPILNKLPTQRNRKVNHDLRTLGTESRYLVERGKKRTEENDSKNSKDILSLMVKEIDEDGLGMTVSELQDQ
CLTFLAAGHETTSVALSWCLWLLAKNPGIQDELREEIRPLFRNLDTDHHIVPSYDDINSLKLLNNVCKETLRVIPPVPVT
NRVTRKEVILGDYILPKGTDVFISIIANHHSKQIWGDDAETFRPSRWDEELASKVSPYEYMPFLAGGRQCIGYKFALVEM
KILLAILIMDFKFSEKPGFEPKKEQLITLRPSPNMTLILEKA*
>CYP5211A1 P450-25_var1 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
28% to CYP547C3, 29% to 547C1 in the CYP56
clan
RO3G_09819.1 revised
MSSDPMIPYAFTHICWLPLLSLPLAYVFIYCRRRYGSSLASVVLAPTDNFITKYLGLVPPPNHAEKTDELSRFLIRAGQD
PRYFPVSVCWSLTGKPLVIASTLKGIKDVLLDGQMKSKVRGEQQPKVQRGNMIRLIHNLVFGGKSLNNVIGEDWRWRRHV
LLPPFQPKQLVPKLLPYVASRTAELLSTFEKYAENGSPVELDNLFMDATMDIINYYLYGRNDLNYDIVGGRTNMK
(0)
FIHNHLGYGFQSLEAWLPFGINKTNWAQKRFKPSRDLLKRFVEDSLKYALEDYEADLKRFEQENVPVNERS
YQSVAACAFASGFYGKDQFDLINDL
LALTFAGYDTTAHTLAFAFSELARDSDLQDKVFQQVRQVLGPPPLSPSSITAEKLAKMPLVTAVYRETLRKYPAVVFIPV
HVNRDTVVDGVIVPEGAEIWCNVRGIQMNPQIFPEPNRFDPIRWLQPDNKGDNAFDNMHGSSSAPLDQFTPETQYKFPEI
AFTLGQHSCLGKNLAILELRMVIACTINQFTFELKEGCHIDTKIVLTTKPRNGVWVHFKKRKS
>CYP5211A2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
62% to CYP5211A1
P450-25_var1 Rhizopus oryzae
fgeneshPB_pg.14__230
MNILSVLSPNISFYTTAFYVGVYSPLAGIIFLVLRYYYRRKNSILSSAPLIPTKNFWISYFGLVPPPDENETVDELSKFL
ISVGQDTQQSPLSVSWSIFGTPLVIVNSLKGIKDVLVYGQVKSKVQGRPSNVQRGNLIRLIQNHVFGGENINNSTGEGWR
WRRHVLLPPFQPRQLVPNLLPYVVKRAHELLDTFGKASDQGTALELDGVFQDLTMDVINFYLYGRSDLNYELVGGKENLK
HMHHKLGLGFQSLEAWFPFGINKTKWAQRAFGPSREHLKEFVKDSIVLAVEKQAEYKSDGQEFQSVTAAALSSGKYHEDQ
FDLINDLLSLTFAGYDTTAHTLAFCFSELARNPALQEELFLQVRAVLGPPPVLPESITADKLAKMPLVSAVYRETLRKYP
AVAFIPAHVNYDTNVDGVVVPAESEIWCNLRGIQMNPNIFPNPDKFDPSRWIRPGDTNDTLGGFDSMAADHTRESPIVTP
DQQYNFPDLSFTLGPHSCLGKNMVILELRTTIACTINEFTCSLKEGSVIDTKIVLTTKPRYGVWANFKRRSEIRI*
>CYP5212A1 P450-45 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
35% to CYP509B1 in the CYP56 clan
RO3G_16456.1 revised
MGTLFNRSNYRLYVLLASILTSSILYQKLSNAIFVPKQLQHIPKVNTLQWFWSVLIGESHDVRVKRLVLPIMNKYGLCLKYVMGNWTLTVADPHYLQMLLKDMKSFPKIQVAMDPDLILTNQAPSLSNCSMNDWKRQRSIANPIFQRAMPVEIFGNVVLKLFRSVDTLNQDGVIDMADYAKRYALDCLGLGLFDFDMAAVSNPESYYSTLYKEAFSIVRDPLVYLFPAYTRIPSKWIPYRNRAHVANERLRRIFYEVIEEKKAAPSTSSDLLSLMIKANHSESDVAYLTDDELISNLSTFFVAGKIFVQRAIASFFYYLAAHPDVQKKARKEVLLILGDDPDDILPTDKQLKQMTFLNYCIKETMRINPPTSGNLPRMTSRVILIGNFLIPKDTIVHLELYCVHHLEKYWDRPQEFIPERFDTASKNYRENAVWMPFGYGPRTCIGLNFSLSEQRVLLAMMLKKFCWKLAPNSEHQHGLRNAHGGGIGLLGPESLKIQLIKRYA
>CYP5213A1 P450-28 Rhizopus oryzae (Zygomycete fungus,
Mucoromycotina)
26% to CYP512B2,
25% to CYP512B1 in the CYP54 clan
RO3G_10623.1 revised
MNSIVLDKKVEQICLSVGVLTAAIVLFKATTSVFSNKVYRTALFHPITNSFIFFTQQSRNGIPLVPYKIPFVGSTMAYYKNMLEFTKKHSEKYGSVFHMHLHGQIITVVGADDAPEAFTHPDLSFLAGQFLGEATASKSAKKDVLPASVIKTSIVKHLTPNLDHYAPQSFEMLCKKAKSVLDAEKGPVVITNPISFLRSLVSQYSARAFVGKELCSDPNLMNAFENAVTDIGKEMTPGFFRVIFPWTLIKTALKSEIERNNGLDKKVNSAKKKQITWDAYFLLKKEPSNILEFILDQYPAEIDDDYLEALTTTILIFIFVGVHTTSMAVAQVLYRLVKHPEYTKELIEEQQEVLKSGYDSSAYSPSAYRQMVKLDSFIRESLRTRSNGIGLPHKNITNQDIVLRSGAIVHPGENVYINMWHVNTNEVNQENMKDTEQFQGFRFVGRDKPSTKPGHDFISFGLGRRSCPGRWFAIQQIKGIISFLILNYDISAASEIKIPGVDSYAGSLSGSIQFQKKI
>CYP5214A1 not assigned yet
>CYP5215A1 Cryptococcus neoformans var.
neoformans B-3501A chromosome 2
AAEY01000006
CNBB0620
EAL22841.1
CF712065.1 = mRNA yellow is an insertion
32% to AAEY01000032, 32% to CYP5151A1
MLKQLSFQSPRTIEIIPLALVVLVVWLFRVFVYKPFTSPLKNVP
CPPGGTSSQGHIAEIMNLQGTEVNQWIKTYGSTFMVRGPFGVHHRIFTVDPRALSHVL
QHTNIYTKSDLLRGLVRRYMKEGLIVAEGERHKAQRKVSQKLFSMGGLKSMGQVVQDK
SNQLRDILLNLCTNPTASNPYSPVNRTLPPGSREVDVYSTASRCTFDLIGSIGVDHQF
DSIGDWEGSGGKLFHKYERMQLLCPGTTGFRMLLSLAWPLIDKIWVNNIFPLPSENTK
RVNDAMGSLEKFAKEKMIERQQELLTIDSKKGDVPDRGDLLTLMLRHNMTRKISPADK
LRDHEISGQLSTFMFAGSETTAGTISFGLCDLARHPDIQSRLRAEILECGDNLPFNQI
DELPYLDAVVKEIMRINPSLPGTVRQAQKDDIIPLAEPVILTNGKVVTDIHIRKGQL
(0)
VHVPIEHLHTSEHIWGPTAKEFNPSRFLSTTQPSAFSG
RPTLASNPAATSSARRDAVPN
YVPEGPGIWPNFMTFIDGPRRCIGYKLAVMEIKTVIFTLLREFEIELMEGQHIFRWNM
()
MSNRPFVANTLRSKGSRLPLHFKLYKGEQQHEKTGGS*
>CYP5215A2 Cryptococcus neoformans serotype A
88% to CYP5215A1 CNAG_04029.1
MLKQLSFQPPTMIGSILLALVILVVWLLHVFVYKSFTSALKNVPCPPGGNGSQGHIGEIMNLQGIEVHQWIRTYGSTFMV
RGPFGVHHRIFTIDPRALSHVLQHTNIYTKSDLLRDLVRRYMKEGLIVAEGERHKVQRKVSQKLFSMGGLKSMGQIVQDK
SNQLRDILLNLCANPTASNPYSPVNRTLPPGSREVDVYSAASRCTFDLIGSIGVDHQFDSIADWEGSGGKLFHKYEQMQL
LCPGAMGIRMLLSLTWPLVDRIWVRIIAFHWYVLSPSENTKRVNDAMGSLEKFAKEKMIERQQELLTMDSKKGDVPDRRD
LLTLMLRHNMSRKISPADKLRDHEISGQLSTFMFAGSETTAGTISFGLYDLARHPDVQSRLRAEIFECGDNLPFDQIDEL
PYLDAVVKEIMRINPSLPGTVRQAQKDDIIPLAEPVTLTNGKVGTDIHIQKGQLVSIPVSYLILVSSLMGWINESPNCQ
>CYP5216A1 Cryptococcus neoformans var.
neoformans B-3501A chromosome 3
34% to CYP63A4 Phanerochaete chrysosporium
AAEY01000013
CNBC2600
EAL22122.1
MKGGRFLLPALFKTLLLPPLIAALFIHHFPSLFPTFTALIYLIS
FPALYVFRSYASLVASSWKASALGAIDIPRVNGTWPLNIDILLNWAKSGTEEEVGRMM
VLMGRQYGGTYNTRVLGEDQIISSDPKVIKHVLIDDFDNFVKGQKFKERAQDFLGDGI
FNSDGDNWKFHRSFMRPFFQPKYISPLHFSTNVQNFFAKLPSYGKVFDMQAHIGQLAL
ELAIMWLCGEDMSRDTNNVAWTEEWKKAKGEISWAMTEAQKIVGKRVKIGTIWPLFEV
RHDPLERPMKVIRAFFRPIISRALNRKRQRCKLDNTEDVYMIDRLVEATDDIKLVEDQ
LINVLLASRDTLASLLTFSVYAIVLHPDIAVRLKDEVFTIANQECEVTKDTIRQLRYC
RAFINEVLRLFPPVPLNIRRTLRPSLLPTPNHLAYMPANTSIILATILMQRDPAVWGE
DAQVFNPDRWLEGGGLGKEKEGFMSWNLGPRMCLGQSFALAITHTFLVYFFRHIAHVG
TLVGHNTTVQLALDAQPPETVLPKEWMTPEGGDGRARGGRDKVWIVADVVLAIKGGLW
IRFGAEETE
>CYP5216A2 Cryptococcus neoformans serotype A
90% to CYP5216A1
MKGGRFLLPALFKTLLLPPLIAALFTHHFPSLSLSFTALIYLLSFPALYVFRSYTSLVASSWKASALGAIDIPRVRGTWP
LNIDVLLNWAKSGTADEVGRMMVLMVRQYGGTYNTRVLGEDQIISSDPRVIKHVLIDDFDNFVKGQKFKERAQDFLGDGI
FNSDGDNWKFHRSFMRPFFHPTYISPLHLATSVQNFFTRLPSYGEAFDIQARIGQLALELAMMWLCGEDMSAGASNVART
EEWKRAKGQISWAMTEAQKIVGKRVKIGTVWPLFELTHDPLERPMKVIRAFFRPIISEALNRKRQRCKLDNTEDVYMIDR
LVEATDDIKLVEDQLINVFLASRDTLASLLTFSAYAIVLHPDIAARLKDEVFTVANQESEVTKDTVRQLRYCRAFINEVL
RLFPPVPLNIRRTLRPSLLPTPNHLAYMPANTSIILATILMQRDPAVWGEDAQVFNPDRWLEGGLGKEREGFVSWNLGPR
MCLGQSLALTITHTFLVYFFRHIAHVGTLVGQNITTQLAPDAQPPETALPKEWMTLEGGDGRARGGRDRVWIVADVVLAI
KGGLWIRFGAEGTE
>CYP5217A1 Candida albicans SC5314
32% TO CYP537A1 N. crassa, orf19_3105
MLKEIAYTLYSYTVAHPVQTQVIVLVALLVYYLVVYPVTSPLWKVPGPYIHRISYIPCYNAQRNGTWIARVHELHKKYGS
VVLLSPNEVSVNGDPKFINDIYVKNFPKSKFYENFRNHGFKDNIFASLENDRHRKYKKLINNLYNKTAIFSKENHTRSVL
LETADKLVETVGKESPSIEVFTLFGALAMDVVSRFELGRTNGTNLLDGFADRRIIVSHREVSSMGFWTTLMPNFLWDYAA
TKTILQAADDICNFQLNLYKFAEKNLTSNGKNLTTLETLKKNGLEGEYAYSFLTDNLFAGHETTAVQLTYLCYELSRPAN
YKMQQKLREELNKAFPDGEIDLETVDNLPYLNALLTENGRVHTSIPGAEPRVVDKPYLVDNMVIPQGTIISCLPYSFHRT
EGVFPEPDKFLPERWIINSEQDKWRVKQQEKYMMPFGKGVRMCLGMNLAMIEMKIAIAKLYWHYSSTIDETWCRVLNDAK
PIKMGGGDDGTTDQDKMRMYDWYTTRPLYDECWLKWERL
>CYP5217A1 Candida dublinensis
93% to CYP5217A1 Candida albicans (ortholog)
cdub_11-g19.1
MLKEIAYTLYSYMVAHPVQTQVIVLIAVLVYYLVVFPVTSPLWKIPGPYIHRISYIPCYNAQRNGTWIARVHELHKKYGN
VIILSPNEVSVNGDPKFINDIYVKNFPKSKFYENFRNHGFKDNIFASLENDRHRKYKKLINNLYNKTAIFSKENHTRSVL
LETADKLVETVGKESPSIEVFTLFGALAMDVVSRFELGRSNGTNLLDSSSDRRIIVSHREVSSMGFWTTLMPTFLWDYAA
TKSILQAADDICNFQLNLYKFAEKNLTSNGKNLTTFETLKKNGFEGEYAYSFLTDNLFAGHETTAVQLTYLCYELSRPAN
YKMQQKLREELHEAFPDGKIDLETVDSLPYLNALFAENGRVHTSIPGAEPRVVDKPYLVDNMVIPQGTIISCLPYSFHRT
ESVFPEPDKFIPERWIINNEEDKWRVKRQEKYMMPFGKGVRMCLGMNLAMIEMKLAIAKLYWHYGSAIDETWCKVLNDAK
PIEMGGGGDGSTDQDKMRMYDWYTTRPLYDECWLKWEKL
>CYP5217A2 Candida lusitaniae
CLUG_02702.1
50% to CYP5217A1 Candida albicans (probable ortholog)
yellow part is too long, may be an intron seq
VTRSSVSGKEPDYINARSASNHNGKGYALGSLDWFNKK this
may be an intron seq (remove)
MKTLNINRSTHYTVSRNLQSSSSDARPIGKWSIALKCACISRFRAQKSGIARPKRKIAELPISRYSVPNLPCLSAIQKML
QDAAIVTARYVLENKNAFLGAIILSLALFKLVIYPFYLSPLKDIPGPYWHRVSHLPALEGQRRHVWIKKVHDLHAQYGKV
VLLSPTAVSFNEDPKYVHDIYVKNMPKAQFYANFTNHGPRPNMFASLDNKAHLRFRRMIQNLYSKSAIFNPKNSTRNSVV
EKVGQLVSQ (0)
GKSSNLGIDVHSLFGAFAMDNISAFELGPENGT
KMLLNPEDRYYLIPFRLIVDMTFWTTLMPRFWDIAAGPVIRKASRLIEKWQLDLYAKAEENVPQRAPGQNLSTLETLKKH
GLQGKNAYSSLTDNIFAGHETTAIQLTYTCYELSRPANKHRQEQLQKELREHFGSPNGDSEVIDDLEAVDRLPYMEALMQ
ETSRLHAAIPGAEPRVTDKNYEVVVGEKKVSLPVGTEVSMQPYSMHRVTSVFPDPELYLPERWLQEPGESEDDYAARMTN
MQRYMMGFGKGVRMCLGMNLARIEMKMALANLYWRYSSDICRDWCTVNEESEKATALNGAKAGLPVGLHSAVSPADSDEK
MMSMFDAYTTRPLHDECWLEWSVY
>CYP5217A3 Candida parapsilosis
56% to CYP5217A1 Candida dublinensis
CPAG_05265 yellow region seems too long
(possible intron)
MLSELLQVFLSLLRLHLLWTLFSVLAIFSCYYFVYAPITSPFWNIPGPYIYRVSIIPALNHQRNGTWIQTVYKLHQIYGP
IVILSPKEISVYGPQYVNDIYIKNFPKSSFYANFTNHGHDNIFASLPNDQHLQYKKIIMRLYNKGNVMSPENNTRRILIE
STRKMLEYVYKSSIK
GESPDFASVAPTLNPHAKGHRKPWFNKSHRAKSL
GIEVFSLFGLFAMDVVSKFELGETNGSNLMD
NPSERDIILKHRQVSSMLFWTTLMPALWDFVATKTIMKCSEDIAKFRMSLYEIAEKHWANNGKNSTTLEVLKQNGLKGPR
AYSFLSDNLFAGHETTAVQLCYLVYELSRSGNHTMVEKLQHELYESFSKPNSHDDVIEDLEKLDKLEFLDALLLENSRVH
ASIPGAEPRVVDRVYSIAGVEIPKGTIISCLPYAMHRDSTVFPKHDYFIPDRWLKYPEESQEEFEQRKKAQHKFMMHFGK
GIRSCLGMHLAWMEMKLVVANLYWHFHSLLDDDWCEIKNDTEPIQLGKKNCGNNSTDQEMMCMNDAYTTTGPVNEECWIR
WVENS
>CYP5217A4 Candida guilliermondii
51% to CYP5217A2 Candida lusitaniae, yellow
seems too long
54% to CYP5217A1 Candida dublinensis with yellow removed
PGUG_02308.1
MLLDFFSFLANAAQTHTSLVIWSLCGVTIIYYLIIYPFFLSPLRNIPGPYHYRVTKLFALNGQRRQQWIMTVHQLHQKYG
NVVVLSPREISVNGDLVYLRDIYTKNFPKDRFYENFRNHGFKDNIFASLENDRHKNYKKILQGLYTKSAILSDRNSTKDL
LNDKVNLLMDQIYNSS
VTAKNPDLINAKCLHNEHGVGVASTWYEKTKQK
GIEVYSLFGALAMDVVSGFELGPENGTSLLS
TPKDRYIIAMFRRVASMGFWTTLMPQLWNFAATGTILAAQQAVEKWQLSAYTKAEKNVPKVTTSLNTLNAAGLFKESAYS
FLTDNIFAGHETTAIQLTYLTYELSRPVHRENQHKFRQELYNTFGKPHDINDRITDLDKVDKLVYLDALMNENSRVHTSI
PGAEPRVTPEPYPINLEDGTKVIVPKGTTISVQPYSIHRQESVFPEPEKWVPERWLQQPNESIEEFHCRIKAQHKWMMPF
GKGIRMCLGMNLAVLEMKLALANIYWHFESKICEDWCEIDCNDNHIKMDSEPKNRKKDYEMMTMMDTYTTRPLYDECWLS
WSIPENS
>CYP5217A5 Debaryomyces hansenii
51% to CYP5217A1 Candida dublinensis
CAG85742.1
MLREIINKTIYTSIEYHLQIVLGVLFLSVIYFLMVRPFFASPLKNIPGPYWNRVSVFPSLNSQRTHKWIETVYNLHSKYG
TVVVLSPYEISVNGSSQYIKDIYVKNFCKGKFYDNFRNHGHDNPFSELKNDVHLKYKKILMNTYNKTSILSPQNPTRSHL
VSTVLKVLGRVRKEQELNKYRAIDVYSLFSCLAMDVILAFELGKDSGTNLLEHQESEEVVHWYRKKDSMGFWTTLMPRFW
NLAATKEIKQAVNSIEQWHMSLYSHAEKNMNEEKQSYCPSLKVLQLNGFHDKNAYSFITDNIFAGHRTTAIQLTYLCYEI
SRPVNRKWQDILKRELVEHFDEPLNNESIIQDFEIVDKLPVLNALLQENLRVHSSIPGAQPRVVDRKYTVEVQKVDKILK
VLIPEGTIISCLPYAMHRQEEIFPSPDNFKPERWLRYNEENDADFKARISNQQRFMMPFGKGIRLCLGMNLALLEIKFTL
ANLYWHSRSEISDKWCKIENTLGGCPIKLGQISQGMNCTDQEKMVMVDSYTTRPLNDECWLSFYFRNN
>CYP5217A6 Lodderomyces elongisporus
57% to CYP5217A3 Candida parapsilosis, yellow
region is long (possible intron)
LELG_05700
MLLDILQATHSFVETHPYQTYVIVTGALLFYYLVFLPVLSPLWKVPGPYLHRISRIPSLHYQRKHSWGEKVYNLHKQYGN
IVILSPNEISVNGSDKFVNDIYLRNFPKSRFYANYTNHGDKDNIFATLTNDKHLKYKKMIVKLYSKSNVMAREGPLKRII
AETTQRLIDVVRKSSVTGETPDFLSIRPEFNPHAKGFTSPNWFNKLKRTQNLGIEVYTLFGCVAMDVVSRFELGEENGLD
LLLHPEERSIVAKHRQVAGMGFWTTLMPQFWEIAASKLVMNALKDITKFQLSLYADAE
ARLEKEDQPEMNENKRDNQQEKEFEELKGRRERKRS
NPTTLEALKKHGFFGNEAYSFLTDNLFAGHETTATMLCYFTYELSRPAHLHIQSRLKEELVNTFGK
PKGPTDIIEDLEKVDSLPFLDAVFTENTRVHASIPGAEPRVVDKKPYMVDDISIPPGTIISCLPFALHREASVFFDPNKF
LPERWLPHYGELEIEFKTRIRQQHKFMMPFGKGIRMCLGMNVAVIEMKMVIANLYWHFASRIDSDWCEEILQDDEPIKLG
KRHKGENKTDQEMMCMNDYYTITPVNEECWLRWFEQ
>CYP5217A7 Pichia stipitis
57% to CYP5217A2 Candida lusitaniae
JGI model e_gww1.7.1.292.1
ILGVFLAYHLILYPFFLSPLRDVPGPYLHRISSLSSLNKQRKGRWTMTVYELHKRYGDVVVLSPTEVSVNGNSKYVHDIY
IKNFPKAKFYENFRNHGFKDNMFASLENDRHIAYKKLIMNLYSKSAIFNKKNGTHSIIVQKVGQLVDDIRQSSSGKTQNL
GIEVYTLFASLAMDVVSAFELGMSNGTDLLLHPEKRHIIISHRQVASMVFWTTLMPRFWNWAASSTILKALYDITKWQLG
LYAQAEENVPDVKEDENKSTLETLKQKGLKGEYAYSFLTDNIFAGHETTAIQLAYMCYELSRPKNLHLQESLRKELIREF
GHPKSEKDIIDDMSKVDVLPYLNSVLDENSRVHASIPGSEPRLVDSPYKVEVGEGKVVELPKGTGISCVVYALHRQSDVF
AEPDQFIPERWLQYENEPDEVFRQRIKRMQRYMMPFGKGIRMCLGMNLALIEMKMAIANLYWHYNSKICSDWCEITEYTE
DSKKLNPILMGETRKGENRTDEEKMTMYDSYTTRPLNDECWLEWYDNQFEN
>CYP5218A1 Malassezia globosa
37% to CYP5031A1, MGL_3996
MAASAFISGADVLYLAAGLAGLLVAVPLLFILNQLVQALYRMTIGELINPWKHIPKVKTTDPLSLIFGDFRAIKAADPAQ
QHVIWMNKLGQVYRYRHMFYVQRVLLADPKALIHVLSPAKAYQYPKPEYTSSFLAAVLGDGLVSIEGEKHARQRKIIAPA
FAPSVVKDYQPTIHRHAKLLVEKLRLIVQQEIDRHSGKIPADTHITGQSESDRSVVLKNPGSEAVIDVLFWLSRTTLDII
GEIGFDADFRSLERGNRDPLANSMATLMEAVLNIDLGLAIFLILSEKPGLQWLRKIPTKRTTTIRDAKKTVEKHAEEIVE
RMRNEILSESQGLSKENFDDGSATRSKSLISRMIRANMASDLKPSERMSNAELMGQMTTLIIAGHETTATQNSWALWLLA
MHPEAQDRLRKELQEAVAKERAEMDNLSEEERAIYDTQPVRDINSLPYLDNVVKESVRMLPSIPSTVRVALKDDVVPLSR
GYKRADGKGTYNSIMIPKGHELFIPLNVIQLSKELWGEDAQDFNPSRWDNLPSSVINAKMPPGHLFAFLSGPRSCVGKQT
AILETQVILAHMILNFRFDVVPGWDLVQRQQIVRRAFVEGQWKEGIRMPLIMTPLN
>CYP5219A1 Malassezia globosa
29% to CYP5218A1 Malassezia globosa,
MGL_1059
MFGEPRLMLTDPVGLDHVLRKRAYAFPKIRLAQRLIGGVMGNGLLVAEGEVHRRQRRAIQPGFHSRAIKRLAPVFQQHAF
NLLAYLRTQTREHDSQLIDVYTPLSAAALDALGDGALGASFGALASLIVHPSGIVHAAHPLTAALDRTLRIASHPSKYAL
LMDTATLYFPILEHIPIGLSSHAFRREARVLFDLAGSIVDDAQARIRCETHDTSPDILASLLRANANAKRARSGEKKHSV
LDHAILTDAELHAQVSTFIFAGHETTATQMAWLLLFLAKDQRRQQTLREAIGAKRAALGLMPHARAEPTEACERALSAEE
LEDIPYLDWCVRECLRLQAAIHTTSRVATDTDWIPLSSGRSIQVHRGMIVLIPLTSIMTSEHHWGADPEEFRPERWAEPT
LKGPRAFPAHNGLSFLMGPRACIGSAFALLEMKVFIATVLSELYFEWDGRPIVPKLWVVARPFDASCQQDACILKIRRIS
S
>CYP5220A1 Malassezia globosa
39% to CYP5046A2
Phaeosphaeria nodorum,
38% to CYP530A3
Aspergillus nidulans
MGL_4151 identical sequences are on the same contig 9kb apart
25295 MSMVVLQSENTRWAILNWILLTVPLILGFVLMSRRTNRVKHASLPPGPLKFPLIGNF
LQINSTHPVVQFKRWAEKFGPIVHVRLFSHDIIVLNTDLVAKDLLDNRGSIYSSR
NPPYFAYDLMSKKKRMVFHRYGEDWRKARKIMHQLLAPNATAMSGMVQELESRQMLHELL
ESQNSETENVHFFRYFQRYTSSSIMTLCYGHRFFSPQDPCIEGIFEAMDILSRKSLPGAY
LVDAVPFLRRLPVALQPWIREAENLHQKEWELWGSFVDRCKREIEIGEGRDCFIKELLCK
GAQLGSEEERTKEQLSDMDIGYAACALLEAGSDT (0)
TASTIASCCLAMLL
NPAIQEKAHAEIDTVVGPNRLPGYEDEVHLPLVRAIIKETLRWRPPTVMGVPHAVTVDDE
YYGYKIPKGSTVIGNSTCSPKILDVLIWPVFAMSHDPKRYPNPELFDPEARFYKSHPGSA
AEYATKRNSLERDHFAYGHGRRICAG (1)
IHMAEKSLFQGVARILWGFNIMHAVDEVTGKPIEVKASPHEQAYTDG
FVSFPKNFSARFHVRSSDHESTIRRHYASAQDAWEQQGLEVG*
23496
>CYP5220A2 Malassezia globosa
39% to CYP5046A2
Phaeosphaeria nodorum,
38% to CYP530A3
Aspergillus nidulans
MGL_4157 identical
sequences are on the same contig 9kb apart
36424
MSMVVLQSENTRWAILNWILLTVPLILGFVLMSRRTNRVKHASLPPGPLKFPLIGNF
LQINSTHPVVQFKRWAEKFGPIVHVRLFSHDIIVLNTDLVAKDLLDNRGSIYSSR
NPPYFAYDLMSKKKRMVFHRYGEDWRKARKIMHQLLAPNATAMSGMVQELESRQMLHELL
ESQNSETENVHFFRYFQRYTSSSIMTLCYGHRFFSPQDPCIEGIFEAMDILSRKSLPGAY
LVDAVPFLRRLPVALQPWIREAENLHQKEWELWGSFVDRCKREIEIGEGRDCFIKELLCK
GAQLGSEEERTKEQLSDMDIGYAACALLEAGSDT (0)
TASTIASCCLAMLL
NPAIQEKAHAEIDTVVGPNRLPGYEDEVHLPLVRAIIKETLRWRPPTVMGVPHAVTVDDE
YYGYKIPKGSTVIGNSTCSPKILDVLIWPVFAMSHDPKRYPNPELFDPEARFYKSHPGSA
AEYATKRNSLERDHFAYGHGRRICAG (1)
IHMAEKSLFQGVARILWGFNIMHAVDEVTGKPIEVKASPHEQAYTDG
FVSFPKNFSARFHVRSSDHESTIRRHYASAQDAWEQQGLEVG* 34625
>CYP5221A1 Sporobolomyces roseus
43% to CYP5025A1 Ustilago maydis, e_gw1.5.259.1
43% to CYP557A1 AY316198 Rhodotorula sp
N-term added back from the genomic seq
MSPLSPSISSEIFELSAFNLVVCTLLLGFVYLAWDYRDGRAIGTKRRPDLYS
PRGQQHFLLGDVVGLVKNQDRAMERF
MEAKKAIPASQKGKALSFTVPYGRRMIEISSPHMLEYVQKTNFQNYVKGPLFHRNLSGLLGNGIFVVDGPEWQSQRKATS
KIFTANNFKGVISTSIENNMSKLMTIIGRHADSGAPFDLAELFFRFTLSSFSEMAFGSNFGALSTETDEPVPFAKAFDYG
QVVMNRRFTNPFWNVTELLDGTRAKMNAANKVMDDFAYRVISEREEMGRGNFTGNQKKEAADKDLLSLYMALRDENGQPM
NRRALRDALMNLIIAGRDTTAQAASWAFFRLILHPELMTPIRKEVDELGQIDYDTYKTLVQTTATFNEALRLHPSVPKNA
WQAVGPDQIPNGPRIEAGDSVFWSDWAMGRDKSVWGLDASEFKPSRWIDEEGSVKKESQFKAHFFNGGYRHCLGMNLAMY
EGVSVIASIIRDFDLTFAPGYLETTEMVDTEFTPRYMGALTLSFAAPFMVRATRRKHA
>CYP5221B1 Puccinia graminis f. sp. Tritici
42% to CYP5221A1, 40% to CYP5025A1 Ustilago maydis
PGTG_09055 model is short, THIS FAMILY HAS
THREE MICRO EXONS
MITFLFANLLAYSLVYLLIKL (2)
LIIVFF (1)
SIGTKKRNDPSFSEIPGWPL (2)
IGA (0)
LPAVMKNRARVLEFLTNNGLK
YGLGFSFTLPGLRVVDISKPEWIEYIQK (1)
TNFENYVK (0)
SLLFQPMWDVFGQGIFMTDGTVWKRSRHAISTIFTNKTFKNIIEPHTEKSLD
GLTKELQAAAEENGSIDFCHLFHRFTLDSFVGMT (2)
FGKDLGIVGTEYSDQSGLGPAK
ATYSATSFVKAFDFAQDQMDFRMAVLSGWKLMEALNGSGEQMKRSCRVIDDFAYSLID
ERMSQSSHKVSSEDEESSSKDLLALFMNARDERGGGLGRIELRDTAMNLIFAGR
DTTAQTLSWAFFHLLMNKGLISKVREEGNDILGEGEGSRRGVTYANHKK
FLWSHAVVLETLRLHPSVPK (0)
NGKIALSDDKIPGGPLIQAGDMVRWS (2)
DWKMGRDAGIWGPDCAEFKPDRWIDEKGSMKQFGQFKFHAFN
GGPRICLGMNLAIFEAVKVIVEVFRSFELEFAAGWLENVPKS
EFIEGIAGSYRVPKYKASITLPMENPMMISVRNYGA
>CYP5221B2 Puccinia graminis f. sp. Tritici
63% to CYP5221B1
PGTG_09702
MITFIFANLLACSVVFLLIKL (2)
LINS (1)
SIGTTKRKDTGFYDVPGWPL (2)
LGQ (0)
LPSILKNRARNLEELTLRGLRYGPGHS
TTVPGIRIVDVSKPEWIEYIQK (1)
TNFSNYIK (0)
GPLSRALAYDVLGDSIFVSDGPVWKRARHATSTIFTMKTFKTTIVPCANQSI
DRLVKVLKSTAEVNQSIDFCNLFYCYTLESFVQMT (2)
FGTDLGLLGIEYNDEEKARSPSKLSQTTIP
FAKAFEFAQDQLDFR
IAMVMGWQMMERLNASMGNRMKASCCVLDEYVYSLIDERMAKMAQISEFEDKESSHSDLLSVFMNARDERGGGLGRTELR
DTTLSLIVAGRDTTAHTLSWAFFHVLMNKDLVSKIREEAIEILGDQDSDQDRVTYENYKQFIWSQAVVYEALRLHPSIPK
SGRYVASDDRIPGGPTVEAGNLVRWRFAWKMGRDASLWGPDCGEFKPDRWIDETGRIKKFGPFKFPAFGGGPRICIGQNL
AMLQAVKVIVEVFKQFDLEFAPGWLENVPKSEAIEGVASRYPTPMYRPSLTLPMAHPMMVSVHRRTSSAEAISP
>CYP5221B3 Puccinia graminis f. sp. Tritici
69% TO CYP5221B2
PGTG_04658
MITFLFANLLAYSLVYLLIKL (2)
LIIVFF (1)
SIGTTKRKDTAFYEVPGWPL (2)
IGQ (0)
LPMMFKNRTRNLEDNTVRALEHGPGFSITVPGIRIVDISKPEWIEHMQKTNFENYVKGPLLRGIMYDVFGDGIFVAD
GPAWKRARQATSTIFTIKTFKNIIVPAANKSLDGLVDLLKSTAQSNDQSIDFCDLFFRYTLDSFVQMTFGQDLDLFGTQY
DGKTKGSSPSKLSASSLPFSEAFDFAQDQVDFRFSVVIGWKLLEGLVGSIGKRMKASCRVLDDYAYSLIDERMASRTYQS
NLEKNEAVDGDLLGLFMNARDERGGGLGRTELRDTTLNLIIAGRDTTAEALSWAFFHLLMNED
LISKIREEAIEILGDEN
DGQERVTHENYKRFVWTNAIVLETLRLHPSVPKNTKCIVSHDQIPGGPTVEAGDIIRWSGWQMGRDASLWGPDCGEFKPA
RWVDEKGSIKQFGPYKFNAFNGGPRICLGMNLAMLQAVKVIVELFRHFELEFAPGWLEKVPKSEAIEGITSRYPTPMYRS
SLTLPMDNPMMVSVKCKA
>CYP5221B4 Puccinia graminis f. sp. Tritici
51% to CYP5221B3, 52% to CYP5221B1, gc boundary at KKIK
PGTG_07113 revised
MGLHLYYRLFWGTNRCFFFSCLGTKKIK (2)
GELD (1)
SIGTSKRKDSKFADIPGWPM (2)
IGQ(0)
IPEVISNFSHPLELGMTRHLTFRPGWSVT
MPGLRLVDISKPEWLEYIQK
TNFHNYVK
GSRFHSVMTDVFGNGIFVTDGQLWKNSRHILAPLFTVKSFKACISPSLRVNL
DTLIEGLELASESRPTVDLCDVLFKFTLNFIVYTTLGKNMGQLDQLHLPPIRPLSPSPDSTFVDAFDFAQNQLDFRFSII
TLWKVFERVNIRLGNKIRSACKTLHRYASSLIDERLASFDQDAQRYHETPTDLLGFSLKIRKEMGGELSREELKDAFLNLIIAGR
DSTGEALTWAFYHLLMNED
LVAKIREEASTITGKDRAGQ
VTYENNKEFKWAHAVVLETLRLHPSIPKNIRFALKADKIPGGPVIEAGDAVRWSDWAIARDPEVWGEDCLEFRP
ARWIDENGNIKQFSQFKFHAFNGGPRVCLGMNFAIFQCVCLIVEVFHNFELEFAPGCR
>CYP5221B5 Puccinia graminis f. sp. Tritici
55% to CYP5221B3
PGTG_07103 revised
MLTSATLQSLLLGGFAYLAYLLFEF (2)
RDR (1)
SIGTTKRKDPLFQDVPGWPL
IGQLAQSLADLSRPLEASTLMALKLRPGFSIT
VPGVRIIDVSKPEWLEYIQKTNFDNYQKGPMFRGLMVDLFGDGILVTDGALWKRARTVTSRVFSANTFKNVIEPSADHSV
DGLLQVLQSSSDESRDLDFCNLFTRFTLDSFVKMTFGRALGLYGEESTTDTEPEACYKHLSSPEAFAEAFEFSQKQMDFR
FTVMTGWELYEKVNLSVGQQMKRSCGTIHEYAYTLIDERLSKISSDDDFTNGETFQNDFLGLMMAVHRQRGHTLNREELK
DAALSFLLAGRDATAQSLSWCFFHLLMNKEVISKIREEAAQLLGTYPSHQGRVTHDNYKQFTYTYAAVLETIRLHPPVPK
NLKFAKADDLIPGGPTVEAGDCVTWSDWQMARDPEIWGADCGQYKPDRWIDEAGKIQNFGNFKFHAFNAGPRLCLGMNMA
IFFNVKTIVEMLQNFDLEFSEGWLENVPKSEVLEGIKADYPTPQYQPSLTLPMKNAMMISVKPRLTQDLTILPIEHLYAC
TK
>CYP5221B6 Puccinia graminis f. sp. Tritici
60% to CYP5221B2
PGTG_09701 revised at heme signature
MSSYVSGKLVVCGLLYLIYLLIKYRDRAIGTSKRKDPSFTELPGWPLLGQLPNMLKSRSRILEASTMTSLKVGPGFSFTI
PGNRVIDISKPEWLEYVQKTNVKNYAKGPLRKDIMLDVLGRGIFVVDDALWKRARHATVSIFTPSTFKTIISPSVNQSID
GLTQVLCSAHKENRTVDICDLFFRFTLDSFIRMTFGKDLGILGAEYGSHSESSAPEFARAFDVAQDQLDFRLAMVVGWEL
IERLNVRSMGQRMKESCRILDEFVYSLIDERLANLSHKSDFQDQDPSHPDLLSLFITTRDERGGGLTRTELRDTAMNLII
AGRDTTAQALSWAFFHLLMNKELVSKIRKETIEVLGGDQESVTYDNYKRFVWPQAVLHETLRLHPSVPKNAIVALSDDKI
PGGPTIEAGNLIRWSDWQMGRDPSVWGADCGEFKPERWIDEAGSIRQFGQFKFHAFN
(0)
GGPRVCLGINLAIFEAVKVMVEVLRDFELEFAEGWLENVPKSVTIDG
LTSQYQTPMYKSSITLPMENPMMIAVKRR
>CYP5221B7 Puccinia graminis f. sp. Tritici
64% to CYP5221B5
PGTG_07100 model is too long at N-term delete part of it.
Added I-helix region
MLTSPVLHSLIISGFAYLTYLIFEF (2)
RDR (1)
AFGTTKRKDPLFKEVAGWPL (2)
LGQLPGSILEIARPWEAGTIMTLKLRP
GFSITLPGARVIEISKPEWIEYVQKTNFENYVKGDMFQSLMADLFGKSILVTDGAAWKRSRLVTSRIFHINTFKIVVEPV
VDQSMHEVLEVLQVAGDEGRDIDFCNLFNRFTLDLFAEMTFGTKLGLLEGNSAVKDEGGEGYSYPEAFCDAFNFSQKHMD
SRFDVAVVWQWIQKMNFRATKKMESSCHTIHDHAYTAIDEKMSKLSTGDLTADDTLQKDFLGLIMLSHLQKGHTLTRDEL
RDDLLSLLFAGR
DATAQSLSWCFFHLLMNKDIITR
IREEAAEILGEDSENVGRVTPDNYRLFTCAYASLLEAFRLHPAVPKNVKFAKANDKIPEGPMIEAGDC
LTWSDWQLARDPEVWGPDCGQFIPDRWIDETGNITHFGNFKFHSFNGGPRLCVGMNMAIYIEVKTIVETLQKFDLEFSQG
WLENVPMSEEIPGVKTLYPTPQYQPSLTLPMKNPMMISATPRKL
>CYP5221C1 Puccinia graminis f. sp. Tritici
46% to CYP5221B1
PGTG_09163
MSELSSHLTVVLLVLVAAKLLSLLIK (2)
KSGA (1)
CFGTSKRQDVYDDLPGWPL (2)
LGQ (0)
(0) LPEVILNSRNLLEWAAQKTLIHGVGYS (0)
VTMPGLRLIEITRPDWIEHVQK (1)
TNFQNYVK (0)
GSLFQEVMSDVFGQGIFVTDGAAWKTTRQTTARIFNTNNFN (0)
NIITPAVHKTLDSFMEVLNFHSETQTAVEMDSLLHQFTLESFVKMT
(2)
QDMGSLKAGLSGQKTEPFAEAFDYVQKQLDLR
FIMTAIWVRLGRFVGNRPKMIAARRTLENYAYELID
SRAANPNKDTQVYQDLLGLFMSFTDEKGLSLSRSELKDSALNLIIAGR
(2)
DTTAQALSWTFFHLIRNPDVVAKMRAEIDQLMASNDELVDYLNYKQFT
YNLAVFYEALRLHPSVPK (0)
NAKFAVDHDKIPNGPLVQPGDCLRWS (2)
DWQMARDPSIWGPDCTEFKPSRWIDDSGNLKQFGQWKFHAFN (0)
GGPRVCIGMHLGTLEAIACLVQVVRTFDLEYEPGW (2)
YEKVPMIRKISPDSTEQTPRYAASLTLPMLNHMRILVHKRKS*
>CYP5222A1 Sporobolomyces roseus
24% to CYP634A1, JGI model
estExt_fgenesh1_pg.C_20096
MIGALSILLISILAYHLVARRKLTPLAPPSFSVPSLPAFLSGLVAIARLGANEDEFLKALRAEYGAVVYLPWPLRQYLIL
EAEAIECVYKAPSRVLSFFPIRVEMQSSVFDAGFETEKSLMEEFYKTHSRGLQKIQLAETMDRFVKVVEAEIGKLATRLD
ASEDGQIECNLDEWVTDIFFEASLSGLFGPLVRQSSGISKTEFRTAFDAFDGAFPLLASGLVPKPFANIVFGKGKKAQKV
LADSLEAWIEEDFPGLPTGVVRDMAQVALDNGLGKREAGKLLVSDAWALQANAPYVASQLLLYLIQAPQSILDDVVAECD
RSISLARNSSSSPQSIDHLSQNFPLLQSCLTETLRIGTSVFSIRDVEQPLHLRSRGGTEVVVPPMSRLIYATRASHLDQT
TWGDDVCKWDGRRFFDREGGGEKDEGGETVEKSKKSRQVWGFGGGISRCEGNVLATLELKSFVSTILTKFEVSLVGPTTT
DSQDYEAVEFARGEAGYRPKRRTGRVGLGVLQFDKDVMVAIRKRRLAGTE
>CYP5223A1 Yarrowia lipolytica
38% to CYP5217A1 Candida albicans
CAG79538.1
MTLTDLVRAEPSGALLVSLATAYLVYLVVVAQLNPLKKCPGPWYTLYSKMPILVIFWRDSRNRYVQALHEKYGPIVRLGP
DEVSICDPKDVSKVYLGNFDKSRFYAQFGNYGAPNLFCILTKEPHIKLRKLMTGFYRKETINGTGIIQEKVDEMETVVAA
NNKQDVHTLFRYLAFDVVTRLTISDSEMLAGRNQKLVFYHEMQTSMTFWTTLQPKWWDLAAALSERQTVLGEKTSISEAS
QRCNDWTFQQTGDPDTLLDMLKSKGVSHKIAMSEVQDHIAAGHETTAVTLAFLFHRLAHDKSIQDKLYAELEPINVTLES
VDSLPYLNGLINETLRLHAAIPGAEPRVCPAGVIFQNVALPKGTIISAQPYTLHRDKAWGDPEEFRIERWSEDPPLAYFM
PFGAGIRMCIGMNVAMGELKLATAQLVKKYEIKKSSPQQQFPTMKDSYTTLPEGDNTLLFEQRAT
>CYP5224A1 Batrachochytrium dendrobatidis
JEL423 (chytrid)
only 25% to CYP617D6 Aspergillus niger
26% to CYP509A1 Cunninghamella elegans
N-term part only, up to I-helix, added the rest from
genomic seq
BDEG_02920
Supercontig 3 1051607 - 1053730 (-) strand
MNAVLGLISTGNGWAKQFESIVTSHSRSRYSLVCAVAIPAIGILILKRWLQPSLLPKGLP
TPPYLPLVGQFFTILP (2)
YANRRQTHEFFEKMRKTVGHIWLMKNMSTDIVVVSDPESVMRLLQNSTEITRGEKLQLSA
QTMFEHSLFVLPGGPVWKKHRKLLQPAFGPLHLRFAAHASEEAIVQLSMLIEDEIRAADS
ECYTIDIYQYMTAISMDIM (2)
GQVTLKHDFKAVRSVYDQEDSK (0)
TPGVFDKLVTFLQR (0)
RLFIPPFLWGLVGLHNSSPEIRSTVGSVVN
MVKAMIKDYKDAHKNDQSNDIKDKKHMDVLERLLHSNSEAQ (0)
LFSEQEIIDELIGFIIAGHE (2)
TTANTMTFIVFALCQNPKVQEKLAAEIHDIYNSLDEELNVDNILRFTYLD
WVIKEAQRCYSVVQQVSRVSTQDIQLLGYTFKKGTRFLLRLADVHQDDRYWKDPKQFNPD
RWAEPCTPGTFLPFGDGQFNCIGQKMALIEIRVIMIHLIRQFAFDLVPNQKLERFSTVTH
GFKNGLKVKMTKRK*
Wrong C-term part
TTASTMTFIIFQLCIHPEIQTKLVTDICEIYSKLDKDIDMENIMHFEYLDWVIKEAQ
RLDSVLQNVMRVSTNDIQLMGYEFKAGTQFMLRIADIHRDERYWKDPLRFNPDRWAE
PCVPGTFLPFGDGAFKCIGQKMAMVEIKVVMIHLLREFQFELVPNQKLERFTSITHGFKKGLMVKISKRK*
>CYP5224A2 Batrachochytrium dendrobatidis
JEL423 (chytrid)
51% to CYP5224A1
added the N-term and C-term part
BDEG_03897 revised (may have a gc boundary at
SLDIM)
MFTTIMSVIPFTMPSISLYFGFMEKKYCPSVYLIAP
VLVCFGLACWRHLSKPLNGLPGPYAWPIVGQFPILLM (2)
FLKNHQTHLYLAAMRKKYGPIWILPSLGIDSVVVCDAKAVQSIFQNSTDIIRPDSGFRAAKSL
FQYALFILPGGPLWKKHRKLLQSSFSLPHLRLAVHASKETAAVISTVINNFI
QADSSKSCIIDIHCYMISLSLDIM (2)
GKVAFKYEFNAVKQTVSGNNEK (0)
GYKLFEKLLVLLQK (0)
RVLLPKIFWSYANIADNSPALRETADYMRLTVKKVIDERDASCESELSKDPLHMDVLERLLNSRTGDL
(0)
VLSEEEIISEIIGFIIAGYD ()
TTASTMTFIIFQLCIHPEIQTKLVTDICEIYSKLDKDIDMENIMHFEYLDWVIKEAQRLDSVLQ
NVMRVSTNDIQLMGYEFKAGTQFMLRIADIHRDERYWKDPLRFNPDRWAEPCVPGTFLPFGD
GAFKCIGQKMAMVEIKVVMIHLLREFQFELVPNQKLERFTSITHGFKKGLMVKISKRK
>CYP5225A1 Batrachochytrium dendrobatidis
JEL423 (chytrid)
frameshift at &, first exon is a guess.
BDEG_08295
MLSNPLLYSKISQIRPCYSIAVVAYSRKATTVSMPITREDTVLSSRWG
(0)
DPIGFLNKQREIYGDAFTLNLVNTKMHFFISPAVCTFMIESSI
(2)
SLFQMQKFSLDQAFYDRCPPFKIQGMTDKYSKLFLKLTATALNQPKMLHAYHPLMTDVVSATIMEFTQSGTLDVFELTSSIAVK
IAIVWILGKQFYKAHADDMVQLILQIEKDIASPLNSFFPGWPHPPCIRMQKAIETMFKWVSHEIKLRRMVNANAPVQCDL
LQLLLNCHECNVLLEADISRFMLTLFLAAHTNTAANMGWTIYELAKHTHLQQ
(1)
HSDSTFTDFYPSS
GTRNLESHMPITTACI &
KETGRLYMKLFTFKEIVVRCSVWWI
GYKILKGELICISPGCVALDSKLFEYPNVYNPDRWLP
NNHKSTTSKPKIIPPMNMPQFGIGKHHCLGERVVLMAIKTIVLPELLRRFECTLDSNEQI
VIPDYFGSISSPFPKHPIRIKVVPI*
>CYP5226A1 Batrachochytrium dendrobatidis
JEL423
26% to CYP5224A1, heme signature is not correct, no CYS in
cyan region
BDEG_02487
MPNVDFRYKNNQQFHKLQTWLTTNYGQITMLYFYSKRIVFVSSPLYAKQILSSSLFVQDEESVKLFEGIVDIPSPEDRKR
HLSTVKQLSMELLHARILDITMERTFRVLISWNEKIRIDSERLVVDLDNVCKAISLDICGLGILSMDFDAVTGLRIKQIT
LSEIVLNKVVRFLHQRANLAPFAWAYNKVGITSSDLVSARTHFKSVLKSLIREQCHPYVDDPLSSVNIIRTLLKDYGTDL
TPENEQAIGADVYRGMLWSNMFLSSALSFVFFELLQNDDVREKATQEIDRVWKATHGKIQLDTLSQLLYVECVVKESLRL
HPVCAYLVKESKESVKVGNYLFPTATQFRISVIDLHQDPLIWNDPSAFLPQRWEKTDANTLPFYPFGDDPDLVVQKLALV
PIKAAVAVFLRHISFEHAKKDTADEVPSATHDIDASGAVCKLYDENSLLECIATQRPLDSLQ
>CYP5227A1 Batrachochytrium dendrobatidis
JEL423
35% to CYP5224A1 Batrachochytrium dendrobatidis
BDEG_02013
MDTTVASASIVTLAAGLAIVSYLQNYYVRIPGPYAYPIIGSGLEVAKYSKEGNYHLFLAWMRTFGPITRINIFMKNVVVT
TDAALIKRATTSSTEFWRDPAFSKIAHSLLDNGLFTLPTGDVWKRHRKNLQPAFAPSHLRQAAKITRERIETLGDYWQQE
AVNNGGSIIVDIFHEFTALTLDIIGSAIFSYDFHASDDLHKKRDQVSQGMVEELVRLVQERFSVPPLLWAFNNLSSYSSR
VKKVNGCIHAVIQDVIDKRKEQMKLGNIPSNDQMDVLDRLLKVHQVAAENFTNEEVVGEVIGFFVAGHETTANTLVLTAL
EICRHPEIEQRLAKEVAQVEKSQGCPINIESVPSLKYLDMVVKESQRFHPVVSNMGRNTLCTIQHNGYTIPANTTLILNT
GGAQKDPAYWDKPEKFDPERWADGFVPIPGSYVPFGDGPMACIGQKMALIEIKIVLSHVLSKFDMELIPDQDLTLVTSVT
TGLKHGLKLRLTPKTVQ
>CYP5227A2 Batrachochytrium dendrobatidis
JEL423
59% to CYP5227A1 Batrachochytrium dendrobatidis
35% to CYP5224A1 Batrachochytrium
BDEG_02014
MSNNSVIAGTLVAAIAAMTYLQNNYLGFPGPFAYPIVGNGLDFVHQTNKGKYQDYICSLQSYGRVVRINVFGANYICTTD
AALIKRVLTSGTEFWRDPTFANISHSLLDLSLFTIPSGDVWKRHRKNLQPAFAPTHLRQAGNITQNQADKLVRYYNSESL
KNDGSITVDIYHEFTALSLDIIGQVIFSYDFHACNDLHAHKVQVGQGYIEELVMFIHQRFTLPSILWGMAGLSSNSTRVK
LASTYMKKLIQNVIDKKKSELKQNDEKDPKCMDVLDRLLKVGPSESENFTDEEVVGEVVGFFIAGHETTANTLVNTTLEL
CRNPEITRKILAEIHQVESTLGHPINTESLSSLKYLEMVIKESLRMYAVVASTYRTTLCRIEHEGNVIPSNTKFIVNIGG
VHHEPVYWDKPEKFDPDRWADGFVPIPGSYLPFGDGPMACIGQKMAMIEIKLALCALLSSFDMELVPNQDIVFVTSITTG
LKHGLKVKLTPRSAASV
>CYP5228A1 Batrachochytrium dendrobatidis
JEL423
32% to CYP534D1 Mgr039 Mycosphaerella graminicola
BDEG_02899
MSASLTKWLRISLVSLPALYTIYTVIRWRLLAAKERRILERLCPTLPVITINFNRTMFGIIDVTHFSIIPTWWMPKILPK
GWQWMGGHDVYQQLGEDTIAIVSPGDRQFWVVDADLVKDIVSRKSDFVKPVHIYTILNIFGSNVVTTEHAEWRRHRRIVS
PQFSERINLSVLQYAAETVRDMLKCWQSTEHTAHGEVRVNVSNDMMKLALHVISGAGFGMRLDWVTSESDQTLDHGHTMS
YKTAVHSMMAGLLLKSILPKFAYLLPIERVQNVKRSFDEFGLYLSEVIRGADKQDESNLLVSLAKAARAEDGGLTEQELV
GNVFVFLFAGHETTASTFMFALAMLASHQDVQQRLYEEIQLILDGNDPQLKDIQNLGYTLAVMNETLRMFPPVVAIPKHT
TSQQTLGKYIIPEDTRVTLHTVGIHYNPKYWGPDPSVFRPARWFTLPECASSAVKTRDFIRSTTQLKSQTSPSEPEHDKT
RSDVPDTASDKPHQSLFSYNRYAFLPYSEGMRSCLGKRFAQVEFITGLAMMMQKYSVHLPDGAQIEEVIESQNRVTLQPK
RDMYLVFKPRTST
>CYP5229A1 Batrachochytrium dendrobatidis
JEL423 (chytrid)
23% to CYP5225A1 no heme
signature. Check
BDEG_08292
MDSPEFNEAIRRAPKGMFKEDENGIHVGFEDLFRKEPKQAGPGEMIGMLYDLGKSDDINAQILFWVVLVIFVIPIVIGMV
FVLFGSHRQKRKLVPAISSWIPFGVTLWFSRAKKYSKGFSIPLGFSEFTVFAGVKGQKLISAFEDDKMSFAQGFKLQFEK
TLVSGRLKIVQDQYLQSGYYLPEMLRARLDHIKNEESVDLFKFSSDIALRLLTRLAIGQKLLDENDDDIIPLMQTTEKTL
MSPGTLFFRSFSFGTSASKTLFQDLRIIIQEEIEFRKENPSDESYYDIISILTKAAPQLSVDGIVSHINLFIFANHSDIS
GTIAWTLYHLIQDRTLQTRVLTEYAQAVSVSDTVKDNVSTQPCLTSIIKEVGRLYAPLFLIRGSFKKQPIGNYDIYFCDI
VATSPAMIALNEKIYESPKTFDASRFLDQQKIQVLTQQQKLLQFNNAQHAWFDHVIAETMIKRTIIPTILETYHIELVDK
KFTPRPSYLESFSTPFSDLPLCVKFSSKACMMDNVSKQSNAKKSK
>CYP5230A1 Puccinia graminis f. sp. tritici
26% to CYP526F1, N-term seems long
PGTG_03316
MSSVSAMSSAEFPFLSLHLLSHSFSGIFFTHRFDFGNLILGEHSTTNSWIQKNAVLVLRRWTEWFTGPHGFYIISFFILG
LLIYDALRPRPLNGIPTSGRYCWALGDSGALYRHMKLNKTRTTFFTDQANRVGPLSQVMLGPAGSWFGRLTGLGSHIVVL
ADGQQLVEVCAKRSREFPDPGLTLDI (2)
YKGIIPNGQLALPTGPTFKHHRRA (2)
IAHSMSSSHLSQVTPKITNSVIELIQL (1)
WKKRSQILDRSGEKYFKAAQDLRLSTM (0)
DTISDIIFGKPFGVMSARLAHLENSNGALSADARPQFPTLARALNVIVAQVARCYISPSKSLFWFMQRLF
NREWRQAKSTVFAYLKNEVEKERITLSEEQSFGGVDSKDPDNVNSVLSLLVKDEHLSKLRGEKPLST
(0)
DEITQELLVYWVAGH (1)
GTMACTLAWAVKLLSNNPEVQYKLRDQLVNTLPSLNERSPTFSDLKVCSSDLGYLDATCFEILR
CGKVLGEVSRTSRVDTMVMGHVIPKDTVVMMPHSRLSGPQQSESEFRPERWI
DCDGKFDAQLPGPLHVFGHGQRGCFGKNLA (0)
VLELKLYIAMLCMELFFDRVPDDVNSMDAIELVANHPQTCVIRPIPWSKISNDPTKHL
>CYP5230A2 Puccinia graminis f. sp. Tritici
97% to CYP5230A1
PGTG_13050 model is short, revised
MSSVSAMSSAEFPFLSLHLLSHSFSGIFFTHRFDFENLILGEHSTTNSWIQKNAVLVLRR
WTEWFTGPHGFYIISFFILGLLIYDALRPRPLNGIPTSGRYCWALGDSGALYRHMKLNKT
RTTFFTDQANRVGPLSQVMLGPAGSWFGRLTGLGSHIVVLADGQQLVEVCAKRSREFPDPGLTLDI
(2)
YKGIIPNGQLALPTGPAFKHHRRA (2)
IAHSMSSSHLSQVTPKITNSVIELIQL (1)
WKKRSQILDESGEKYFKAAQDLRLSTM (0)
MDTISDIIFGKPFGVMSARLVHLENSNGALSADARPQFPTLARALNVIVAEVARCYLSPSKSLFWFIQRLFNREWRQAKS
TVFGYLKNEVEKERITLSEEQSFGGADSKDPDNVDSVLSLLVKDEHLSKLRGEKPLSTDEITQELLVYWVAGHGTMACTL
AWAVKLLSNNPEVQYKLRDQLVNTLPSLNERSPTFSDLKVCSSDLGYLDATCFEILRCGKVLGEVSRTSRVDTMVMGHVI
PKDTVVMMPHSRLSSPQESESEFRPERWIDGDGKFDAQLPGPLHVFGHGQRGCFGKNLAVLELKLYIAMLCMELFFDRVP
DDVNSMDAIELVANHPQTCVIRPIPWSKISNDSTQHL
>CYP5231A1 Puccinia graminis f. sp. Tritici
38% to CYP5093A4 Phaeosphaeria nodorum, 37% to CYP5065A1 Nectria haematococca
PGTG_16636
MLSISENITILISIAILTLYLQACYSNRNKKIRNHHHHQTDKKTIKKEIPQPTGWPWIGNLYQIRRPNPWIQMARWTKQF
GPIYRLKMGSSDLIVLGSPKAAVDLLEQRSSKYSSRPRNIMTSEYVSKGLRLTFMPYNDLWRRQRKLLHLLTQPKAAANY
QPIQAQESAQLCLDILNHPNDHWKHSQRYAGSTVLQIAFNRRALSFQDPAITKMRECNEKMIETAVPGRYLIDSIPILSY
LPAILSPWKRYGNRLFNETLALFGQLYRDVLRSESPHPNLAPSDGACFVARIESLKESYRLTDDQAIFLAGAMFGAGSDT
TADAIETFIFACAANPEKVAKAQEELDRLVGRERLPEFSDEDGLVYCGAMVRELLRWRTVIPGGLAHMSTEDDEYEGYFI
PKGTTIVANHWAIHLDEETYKDPSKFIPERFIDPQTGSLIGTKSSVYGHHAFGFGRRICPALHIANKSLFITFTRLLWSF
EIKIKESSLLSPEEFVRAVEFSTGFSSHPIDLNDSLIEILPRDRSSLAVLTEAVENAGIDPIKL
>CYP5232A1 Puccinia graminis f. sp. Tritici
very poor match to other sequences
PGTG_08206, seems long in the middle region
MSSSSESYLESDPTVSSKTFSLTLRPQLFFAKAQHAVAKKSQQRALSCFTGSWDITSRFKTEHNSSTNFWKYSPRIWTWP
WIGSLCSYTRDPLGFIQTQHRSQGDVFTTTILGYNCTFIQSNEYIQSFATATRKVLDVTAAYKLIAAPLIGEEAFFGQTK
YMHQVVLSKSRTELLHQRLWELAEELLEIKWAQCFSSGDQTEVRNWQKIDLGQMLDYVIFGLDVFFLIGEEMVNVNLDRI
SHLFRVMDSDLSLLGILLPMIRGGRCPRKEAKNELLGFLKRDVQRRIERHVQHAVNSAFGSSQSDCAETWPDGPEEDSQE
LPDILLRSELKELDEAILFDYHRGESSAIKLINEKVEFIAIFIYGFVWAAQTNSAAATIGLVHDILLHDQSQALSDEHSP
CFSHAEQIRRECASAVVKDTPSPAPFLEDMPHLAHCLNETLRLRATGAWVRLADKSFHLSPQGNQTSGVICPPGFIVLSP
MPVSLNPSTYPNPSRWDPYRYERAPFISSPSGSNKDAARHIPIDKQYLVPPTTPSSPYFASWGLGQGHCPGKHLAYKMIS
MTVARFFDKFEVRPTKEYFENANFEDVAVAGVQRLKNEFTVLILSITRSKFHWVYQKEVHKTGMSGIARVYGKEAVVVLI
AATSLCLKHSRRLNINLVCEDENVGQWKLFEGQSKPQLLVRVKLVIRHASNPVIANWGAGSEDLFLQTNLQRGVR
>CYP5233A1 Puccinia graminis f. sp. Tritici
35% to CYP63A2 Phanerochaete chrysosporium
VSKKFSFYMLFAEFMVVLIPRVTMITQTK removes as a
predicted intron
PGTG_08907
MSRVALLLSFVGPLLLSKFLLESFERNPSFLDRLVVFCLSWPIAREIRLRLEQRDLRARASSRGALLAPLVSSPLPFGLS
VLLTRLRMIHSGSPGDVIHLFNSRVPKPIHPDQPTKVFRSRVMGVETIWTIDHDDAKYFLSTGFPNFGKSPLFKAGFRRL
LGDGVFASDQRGLWAWHRSLTRPHFVRERIADVVAMEEHSHRVATWLSTQTDLGKSVDIQDIFARYTLTVGTQHLFGRCV
DSLNDLIHDRIQTGPNAADFAQNFVAAQHWAIINSLLLHPLLISLGFRIRDRATEEVRQVVDTLVQDASLSLASQIKKNN
ESDSSDQAEGGTASENLLDHLLTSGCSKELVRQECLNILLAARDTTASLLSSCIYELARDSPRKTAMWRKLKDEVERLGS
GIDVTLDQVRELKYLRAVLNESLRLHPPVWANTRHAFEDDVLPSGVFVPAGTDCRFFIREFQRNPEVWGK
(0)
DAEEFDPDRWIDSRKALQVKDPFSFQPFSAGPRICLGQQFALAEASMMMIRVIEGFEGVDL
DLSDGPVGAEAPAVVLSFRGGLKVRFKK
>CYP5234A1 Uncinocarpus reesii
32% to CYP577A3 Nectria haematococca
UREG_00753.1 revised
MGLLATVLLLSKWKLLACGLITWMLIDLSQAIIRVLTSPFPGPRIAKFTRWWIRWKQWN
(1)
GTDRHDILLMHRKYGPAVQLGPREISFCHADALPQIYAGPKGLDSGDALLALRNYGTDNLITTLDADLHAARRKM
IIGLYSGPAVAAPAFQAGFKKYIEQFMQVIEAKATASPCRTVDVSSWLRWLTGDIVIHHVYGEKNHPNLLREEKSRETFN
ELFATTMDTMTGPFAILAGWFPRLTTPLRKSLAPDKIGRSMMEQVESAIISKVPENKETPVTHLEQLTSILKKDGPSHIL
PDKNFIASDCFDNFAAGSFIPADLLCALVWELSLPQNKTYQNKLRQELHDAGISPGTYPDLSVVQKLPYLDGVLREVLRL
YIPLPFGLPRVVKKGQEVTVLGTKIPAGMTIHSQAYCLHRDPNAFPDPENWNPERWNIPIMSPKYREMQRMFWPFGSGPR
MCSGKNVAWAELRLTTARIYSTYETALDQAFLDKNGALLPNQERKGYFPFKLAEPIRFLKV
>CYP5234A2 Coccidioides immitis
69% to CYP5234A1
CIMG_00783.2 MAFVTLFTALSLPKWQLLALGLGIWVALDICRGIFRVVTSPFPGPRIAKFTRWWMRWKQWKGNDKHEILLLHRKYGPTVQ
LGPREVSFCHADALPQIYSGPRGLDAGESLLAFQNYASENVVTTLDADLHAVRRKMVVGLYTGPAVAAPAFQAGFKIYIE
QFMRIIEERAVAAPCRTVDVSSWLRWLVADIIIHHIYGEKDHPNMLTNEESRKIYKGLLITTADILCQPFVTFLGWFPRI
STLFQRLFGPDEIGTFGMKRVEAVLSANSETKEPSITHLQHLTSTLKKNGPSRVLPGKNFIASDCLDHFIAGYFAPGDLL
AALMWELSAPENRIYQDKLRHELHDAGILPGKYPDPSLVQRLPYLDCVLREVLRLHLPLPFGLPRTVKQGQNVVVLGTKI
PAGTTIHSQGYCLHRDPGAFQEPERWNPERWNIPITSPKYREMQRMFWPFGSGARMCSGKNVAWAELRLITARVYSTYQT
ALDEVFVDKDGALLPEEKRKAYFPFRITLPIRFLKI
>CYP5234B1 Histoplasma capsulatum G217B
ABBT01000117.1 Ajellomyces capsulatus G217B
45% to CYP5234A1
HCB03660.1
MSAVANLLTYLHCEFQLGWPLIAISILSLMILNICRSMY
RTINSPFPGPKLAKFTSLWLRWHELR (1)
DGILNTTHRAHRNYGPIVQLSPKMISFCHPDAIKDIYTGPRGGLDAID
532319 LVWFFERYGSPNVVSTVDAELHLIRR
KNVAGLYSSPVAASPAFQAHIKTTIDTLMNEIEAEAGSEQVLSWTVDV
FPMMRWLTADIMIGLTYGREKPLNLLSNPDSRAQMNELLTPTLELVASPLMTAFQWLPLPIMKLLSPLINPGSKLTTFGM
SLVQESLNSLPLQSKDDDGRKANTHLQHLLCLFKKDGPSLAIPNINYIASDTLDHFSGGTTTTADFLSALLYHLSLPENK
HHQNKLRQELRAVNNGSCPASSTEHIPLSQLQALPYLNGVLRETLRISPPIPFSLPRVVKTKDQDVTVMGLKINPGTIIS
IQPHTLHRDPDTFPNPDVWDPERWQVPITSPAHRQMQRMLMPFGYGQRMCTGMNVAWAIMRQVTASIYREYETSLD
533854
EGVWFEADGELASKDVKHENRRRKKKNLFPDGGVQPIVFRRV*
>CYP5235A1 Uncinocarpus reesii
39% to CYP570A1, 37% to CYP570B1, 34% to
CYP570F1
UREG_01459.1 revised C-term and N-term
MALFGNTTFLVGGVALLIYAVIVRFTTWRRLCHIPGPTGLGWSRLWLFHHFVSGRLCYKLEDVCATY
(1)
GPLVRVGPNYVVCSDPSEIRRIWSVHSGYYRSSWYKA
IRVDPTRNSVLTICENKAHHRVRGYLVGGYAGKGINNQEQLVDEQVEKLISLIRRKYISTRSALQPLKMDQTMQYLTQDV
ITAVGFGKPTGYLDADNDIFGLFKTFQSTILPFHLLAMMPAVVDFLQTYIMKPFVPKPTDTHGVGKLLGVIKAHVDTRYE
PERVRNDDVLQTFVDSGLTRSEVEVEALVQLLSGTDTTATALRNIIFYVCTNPSAYHALQAEIDIAAETATRPVIADQHA
KSLPYLQACIKETLRLWPPIMGLMPKTSDKDDEICGIRVPAKTQVAWVPLAMMKDRTVFGEDACVFEPRRWIDAQPARLR
EMEATHGLVFATGSRWECLGKRLAYMEMGKTIFE (0)
LFRRFDFVMIDPVEPFKWKNYGLTIQRDMNVKITNRTIASNE*
>CYP5235A2 Coccidioides immitis
74% to CYP5235A1 Uncinocarpus reesii
CIMG_02277.2 revised C-term
MVLLSSTILVIGGVGLFIYSVI
TRFVSWYRLRHIPGPPGVGWSRLWLLRHLFSGRLCNKLKDVCDEY
GPLVRIGPDWVVC
SDASEIRRIWGVRSGYYRSPWYKAIRIDPTRDSILTFCENKTHHRTRSYLLPGYAAKGIENQEQVIDEQVGKLVALIRSR
YISTRNALRPWNMGQSMQYLTQDVITAIGFGKAVGYLEADTDIFGFFKTFRSAILPFHCLALLPTVVDILQIFIMKPFVP
KATDKRGAGWLMGIVKTHVDKRYGPEKVRNNDVLQSFVDSGLSQSEVEVEALVQLLSGTDTTATALRNIIFYIATHPRAY
RLLQEEIDAAAQAVTRPVIADQEAKQLPYLQACIKETLRLWPPIMGMMGKISDEDDIICGIRVPAKTQVAWAPLALMKDR
VVFGEDARTFEPQRWIDADPVQLKRMEGTHGLVFAVGTRWECLGKRLAYMEMEKTIFE
LFRRFDFVMLDPVEPFKWKNYGLTIQHDMNVKITSRGIACNE*
>CYP5235A3P Aspergillus clavatus
AAKD03000007.1
mid region is 54% to
CYP5235A2
ACLA_002830
RVYQWNRWRHIAGPPATGWTKLWLIRQAWSGRLCDSLYNACREY
GPLVRIGLKWVLCGDPAEIRRIWGMNSGYHRSDWYKAVRLNSEVDNVLS
TMQYLTQDVITAVGFGKPAGCLEANSDMYGILETSEALYRPIHMITLLPTLRKILESRPL
NPFHPKPHDGSGVGRFLGYIKDLVDERYDDLKANHTDILQSFIKPGLNRPQVESEALVTVFGGTDTTSTALRNIIFYLST
TPRAYRALQSEIDGAVKTMTRPVIRDAEAKALPYLQA 675906
>CYP5235A4 Neosartorya fischeri
59% to CYP5235A2
NFIA_023520
Note: this seq has no ortholog in A. fumigatus
MLAPHVWLIGTLWFLVYFLGRRVYQWNRLRHIEGPPGTGWTKLWLLRQAWSGRLCDSLYNACREYGPLVRIGPKWVLCGD
PAEIRRIWGINSGYHRSDWYKAVRLNSEVDNVLSVIDNKEHHRLRSHLMPGYGGKGIANEEQLVDQQITKLVALIEQRYI
STQTDLRPCDLARTMQYLTQDVITAVGFGKPAGYLEANSDIHGILETSEALHRPVHMVTLLPTLRKILESRLLKPFHPKP
HDQSGVGRFLGHIKDLVDERYDDLKTNHTDILQSFINSGLSRPQVESEALVTVFGGTDTTSTALRNIIFYLSTTPRAYRA
LQSEIDDAVKTVARPVIRDAEAKALPYLQACIKEGLRIFPPSMGLMGKVCPRDDTICGIKVPANTQVAWSALAIMRNRTI
FGDDADVYEPQRWIDAPVEKRKEMDASYGLVFATGTRWECLGKRLAYIELGKTIFELFRRFDFAMVDPVEPFRWANHGLT
AHFGMNVRITEREAGGDVGVFRL*
>CYP5235A4 Aspergillus terreus NIH2624
AAJN01000135.1
93% to CYP5235A4 Neosartorya fischeri
ATEG_04721.1 gene model is a fusion protein,
revised
102330
MLAPHLYLIGTLGLLVYFLGGRIYQWNRLRHIAGPPGTGWTKLWLLRQAWSGRLCDSLYN 102509
102510
ACREY (1) 102524
102580
GPLVRIGPKWVLCGDPAEIRRIWGIKSGYYRSDWYKAVRLNSEVDNVLSVIDNKDHHRLR 102759
102760
SHLMPGYGGKGIANEEQLVDQQITKLIALIEKRYISSKEALRPCDLARTMQYLTQDVITA 102939
102940
VGFGKPAGYLEANSDMYGILETSEALHRPVHMVTLLPTLRKILESRPLKPLQPKPHDGSG 103119
103120
VGRFLGYIKDLVDERYDDLKANHTDILQSFIKSGLNRPQVESEALVTVFGGTDTTSTALR 103299
103300
NIIFYLSTTPRAYRALQSEIDGAVKTVTRPVIRDAEAKALPYLQACIKEGLRIFPPSMGL 103479
103480
MGKVCPRDDTICGIKVPANTQVAWSALAIMRNRAIFGEDADIYEPQRWIDAPVERRKEMD 103659
103660
ASYGLVFATGTRWECLGKRLAYIELGKTIFE(0)
LFRRFDFAM 103839
103840
VNPVEPFRWANHGLTAHFGMNVRIT
>CYP5236A1 Uncinocarpus reesii
36% to CYP625A1
UREG_04196.1 revised N-term
MDTLVEQNLGVNPRIILVSIVLVLFIIISVVHPLYFGPYS
HVPGPPLGKISWYYIAWY
DFWLRRNDKIAQWHLRYGPVICFRPGEVSFASSGLMREIYGTAGKYTKSELFENFMVYGQKPLFSIGPYWEHRKKRMLIS
SFYHKTSITRPVMEKWLRQNIMKLVAQIERAIVQQHGNEDKAPAKAMLDAYPLFNCFAFDNITHVLFGSKYGAKTIANDC
PERKILLGIKQAQMWGPFKFNFPALAWITSKAMHVFPTGIASLLVPDTLRLCLKSEDEMASWNWNTLQTALADLDAVEDY
TLLQRMLSCRAKAPETLETPYIAAELYDNINAAQETVAVGLIYLIFHLARQHSWQARIRSDLLSLNIAEDGFPAWTDIDK
LSSLDAFMREALRVNPGASGRQERYIEDSKKDYNGICLPIGTRVTASTIALHQDPSVFPHPEEFRPERWLDQTPETLRQM
ENSFIPFGYGARICLGKALGIMELKMLAAFLLLRYEIATTPEMGDGKSGPMWQCGSIEAVPIGLKGEMIFTKLDMY
>CYP5236A2 Coccidioides immitis
77% to CYP5236A1 Uncinocarpus reesii
CIMG_06187.2 model is long at N-term (deleted
some seq)
METLAEQHPSENFRVLPLFVILTLLVYIIVVHPLFLGPYS
HIPGPKLGKISWYYI
AWYDFWLQRNDKIAKWHQKYGSIICFRPGEISFASPELMREIYGTAGKYTKSDLFENFMVYDQKPLFSIGSYWEHRKKRM
LISSFYHNTNITRPVMEKWLRKNIHKLMANIDKKIGQTRGNSDGTMVKGMIDAYPLFNCFAFDNITHVLFGSKYGAKTIE
NDCPERKILLGIKQAQMWGPFKFNFPALAWIASKMMHILPANVAYRLLPETLRLCLKSEDEMAEWNWRSLHAALADLDSV
EDYTLLRRMLACRTKDGNTLTTSYIAAELYDNINAAQETVAVGLIYLIFHLARQKVWRTKIRNELAGLSLTEDGYPGWTD
IDGLPLLDAFMREVLRVNPGASGRQERYIEDPKKYYGGFRLPLRTRVTASTIALHHDPQVFPDPEEFCPERWLHQTAEKL
RQMEKSFIPFGYGARICLGKAFGIMELKMLAAFLLLRYEIETTPEMGDGKTGPMWQCGSIEAVPIGLKGEIVFTRLHSMS
SRSSTKYMERD
>CYP5237A1 Uncinocarpus reesii
38% to CYP685A1, 31% to CYP613E1
UREG_06495.1 deleted C-term extension
MDGVPMKELNVGGTSKAAIVFLPLQTSKQGEDLAHDEPYILRNGKHREVVIHTAEHVREFLRNDSKDHFRPTDLNFGDYF
YQVLGQCVGALSGEPWRAVRRYFDPAYTHNAGLGLIPSFQAEVVKWLTALKNDSLRSGVGRMVVHAPTSCKLLPLRVIPL
SFYGEAFDDEAYSHLLRISKLQGQALKYAVTGRWQKYRWYNLLPTSSSQVLEQYHRDWRKFNMGILETARN
(0)
KGLEIPADHVFKGVEKDSAISMEQ (0)
YLQTIDEMIFTNIDITGNVIAFMFTQLAKHPEFQQKLYEEIIAQKCESELDLKQ
YITQQSTLLHYLCLESVRLHPAI (1)
WFSVPEYTAIDK
VIGRYKIPAQTPVIIDVRRLNTNALTWGPDGGEFRPERFASLSPNEYRYGFMRFGVVSGRCLG
KHMADVLMKIAIITILKQYRIEEVEKNIGVKEGDLAFIQRK*
>CYP5238A1 Uncinocarpus reesii
31% TO CYP559D1, MISSING C-TERM (ADDED BACK
FROM GENOMIC SEQ)
32% TO CYP5195A1
UREG_07659.1
MALLSTLVQLLAPLSIVFICISLGRALFRPAQSTLWSQPVVGLRKQWAAWLRATLRSSYNIKQLVFEGYTKYGSAGSAFV
VPSIDRGPIMLIPPREVKRIYTLPESALDVRATQQETNQTRWVTWDKKPAEDSFVFDVIRQQVTRNLKHLTPVIGSEIQL
GFERCWGAETEWKEIKIWDTCWQIVTGAVNSALCGMPLCRDPEFLKGCQDHSLVIMAGAMAINASHSLLQPITGGLIWLT
CNVFFKRTLKKCMPVVKERLEKTAKLKTDPTYDWTPPKDAIQWIIDECYDTGNLARLDPKSICFRLLLLNDVSIPSTSFS
VQSFIVDLFTADPTRGFVEALRKESEAAFEESGGIWTVDAVKKLKLVESAIRESMRLSPLGSIALPRT
(0)
VVDRSGISLSSSDTIPHGAAVAVPIEPIHYDEAIYPNSKSFDAFRFAQPDSVRDIMAKL
APKEDGPEKSNEDAGKRTTTANLDEAFFGFGVGKHTCPGRFFALNEMKIFVAHMLLNYDV
EYLKVKPELVDFVWLKIPWNSGTLRVRRRLKRS*
>CYP5239A1 Uncinocarpus reesii
38% to 578C2
UREG_07892.1
MSEIVWAVLFISISTTAAWFFYTRVVWPVFFTPLSKVPHAHPSVGISSFWINRIRSTGYANETIHRIHEKYGPVVRLGPN
EISINCVDEGVKKVYGSGFEKSNWYRKFDYFG (2)
NMFSARINAEHTKRRRLLSHIYS
KSTLMHSPNLHQNVIEVMLQRVTPILAEAANTESPLNVFDLYRASTLD
FVSAFLFGPESGTNSLENRQERANIFRMYADESKAPIWRHPLLGFIAPSMNNSMDPGLFHLCMRMCESAKARLLSHIDSG
SKGLVFHQLQEAGLNPIEMASELVDHFS
KSSMATSQFKSRILTRSVA
AGHQTSSATLTFLSYQLSACPDVQEKLREEMRSILPMPMRTGDPSMASYLKS
LDALPLLDAVVMETLRLYPPIAGPQPRITPNRPMPLGPFTLPPRTEISAQAFSLHRNPDVFPDPLHWVPERWLEKNRNDM
RRWFWAFGSGGRMCIGSNFAMI (1)
QVKLLVS
IVYTQFRTVLVENEKPSPRDGYRGGPKREVLDLQFSCL
>CYP5240A1 Uncinocarpus reesii
28% to CYP639A1 Fusarium graminearum
UREG_06632.1
MLTIFTGWMSSVALYATIAISLPFIITWLSSSFRARWPRNGEPPMVPHWIPWLGHAYSYLFDINQFGQRVKKRYPNAGAV
TCLVGGRHYYTILDAKLAGQIFRRPKPFAMEPFIVASHEAFGTPKADTEVMKMGIPGLEHECGYRDDGRRIWHTLGKMIQ
EHLGVEGSIHMAQTFLGQLSDDLQKVFPKQLKSTEWVTLDLRSFIMKHYLHASAASLFGTHLLDLWPTISEDFWAYDEYT
KIHLAQIPEILAPKSYDCRRKILKILLQWEKDARDNRNLDKLIAEDAAWDEYWGARLMHHRTKYTAESGLSPEARASMGL
VFLWGQNANAIPIGVWMMIHCLVDPNVKRRVLSAIESCRKPEGDIDMHRIVTHTYLKSVFLEALRYGVAAPTVRDVLETT
QIGEYTFHKGSVIHLPSRILHMDDEVWCSKGATVSASSFWSERFLDPEQNENIENAGAGFSKAAADPIALPVGTRSKDIR
DRMPAFRAFGGGNHLCPGRHFALYEIVAGMATMFTMFDIEVDEDALRVNGMPAVDQRGIGGLPPDRKFMVRMRRK
>CYP5240A2 Coccidioides immitis
71% to CYP5240A1 Uncinocarpus reesii
CIMG_04920.2
MMLAVLADAVGSPVTVYFAIALGLPFLVTWLVSNFNARWPRKGEPPMVPHWIPWLGHAYSFLFDINGFGARIKKRFPKEG
AATSVVGGRHYYTILDPKLASQIYRRPKVFPMEAFIIASHAAFGTPEADLNVLKMGIPGFEHESGYKDDGRRVWQTMSKM
LQQHLSMEGSINMATTFLRKLTENLEKEFPKNTSSTDWISIDLRSFILKQYVMASVASLYGSHLVDSWPTICEDFWAYDE
YTRIHLAQVPEILAPKAYGSRRKILNILLQWEKDARQRKDLEKMLAEDVEWDEYWGARLIHHRVKFATENGMSSVARASM
ALSLIWGQNANAIPIGLWTMIHSLVNPGVQQRVSEAIESCRKPDGGFDMHQVVTHKYLKSVFLESLRYGVAAPMVRVVLE
TTQVGQYTFHKGNVIHIASRILHMDDDVWSRGAAVGASGFWGERFLDVERDANGNIEEKTNAEAAVSKAAADPISLPVGT
RSKEIKDRMLAFRAFGGGNHLCPGRFFALYEIVAGMSTLLTMFDIEVDQEALRTNGMPVVDQRGIGGLLPDRKFMVRMRR
K
>CYP5240B1 Histoplasma capsulatum G217B
40% to CYP5240A2 Coccidioides immitis
39% to CYP5240A1 Uncinocarpus reesii
ABBT01000077.1 Ajellomyces capsulatus G217B
HCB02347.1
94504
MLSSIQFNTTLEMMLCIFIVLVSPFLTTWLITNVKARNGSWQKGEPPLIPYIIPWLGHALSFRRGTTRFSSWVK (2)
EKYHNVPVSRTLMAGNNLYTIFDPKLAREVDRRPKIFTFDPVVLLVNKAFGAPQADLNILERGYLGPTQRTTSNSDGQGMIAELHR
QHFPYLNGPNLPAMISKFGAILSANLENVFQRKGSCDTSDTWITLDFREFLMRQFTLASIPMLMGTRILEIWPLAFKDIW
EFDSWALVLTMNLPSIFIPEAAASRDAMVSALERWEEEASRHRKFEDVESEDP
AWDEYWGARLVRQRHRTFLNNGISKRGRAVFHLGLLWA (2)
TNANAIPAATWMLIHCVL
DTQLQCRVRHAIISSKRKDGTVDIESLAANKLVKSLFLEILRVYVSSPSVRLVLETTELGGYVFHKGGTIFIPGREMQND
PNVWSPNGSFPDASEFWAERFIDEEQDDN
GRIGKEING (1)
YGQTLSADAMTIPGRTRSKSLRDRMYS
MRPFGGGTSFCPGRNVAMYEIVVAVVVILSAFDIEVDKEALASNGIPQPNFDLSGTMGPDRQFVVRMKRRTAAK
92543
>CYP5241A1 Coccidioides immitis
CIMG_09641.2, EST GH380914.1, GH380913.1
Very poor match to known P450s, only one
intron
MGKAKPPEFGSGRKATLLSTINQSLSFHASPELFLSTAPGAADETRDQSNALPSIVRAKILNRDVAVISSYRHCRDILQA
THGASLSPTEPGSVARDGGDPITPSTFTVGPAYRELMSDFFPLPNLLLLDLPGHSQAKLHWEEHFARVFAQIPNLIRDTV
VHHLTTWSHGSTVDLYEQMKDLSWKVLCAVFLGLSPGDDQYRTIISLQEDLMRGQFSLFPVSINTPLWRSPRCKGIEARK
KLQVVLGEMITTRTTDSNPTCPFAQPSDSDGGLNSEELAGNTLLFTSSIAIKALASLLTASLLNLFLFPSQPPLASLVRR
KHAHGKTHEDGDLLRSILLETERLSPPVIGVMRRVEHDVVLTECATDPALQHQVVVPAGWDAWLYFVGASRDASIYQNAS
QFIPDRFLSQLEPSPPLAFGAGAKACLGREVTRTVVKTVASAMLETGIDLVGSIDRKGVRGWLGWDDNVPVDIIAKELKQ
LPCQRPREPIRVRVVRGE (2)
RLKDAIMQISQLSDQIFKYPFSDPNEQPSCVGGHDNPSAQLALPS
>CYP5241A1 Coccidioides posadasii Silveira
GH435524.1, GH435523.1 ESTs, ortholog to
immitis seq
96% to CYP5241A1 Coccidioides immitis
SQAKLHWEEHFARVFAQIPNLIRDTVVDHLTTWSHGSTVDLYEQMKDLSWKVLCAVFLGL
SPGDDQYRTIISLQEDLMRGQFSLFPVSINTPLWRSPRCKGIEARKKLQVVLGEMMTTRT
ADGNPTCPFAQPSDSDGGLNSEELAGNTLLFTSSIAIKALASLLTASLLNLFLFPSQPPL
ASMVRRKHAHGKTHEDSDLLRSILLETERMSPPVIGVMRRVERDVILTECATDPALQHQV
VVPAGWDAWLYFVSASRDASIYQNASQFIPDRFLSQLEPS
PPLAFGAGAKACLGREVTRTVVKTV
ASAMLETGIDLVGSIDQKGVRGWLGWDDNVSVDIIAKELKQLPCQ
>CYP5242A1 Coccidioides immitis
34% to CYP5237A1 Uncinocarpus reesii
EST GH381634.1, GH381633.1
CIMG_06709.2 (n-term), CIMG_06710.2 (C-term)
same gene
MNGTAVTHGGPLVSSIEFVLLHPFLQGQNSLIAALIVLVASAFFILNAQAPKIPNHSIYFKNNAGKKLQLMAGDTRFRRF
LNG (2)
KDMSKEGSVKFGQDPFMVKNGRRMELVVSTPEQVRDFLAKDAT ()
DHMKRSDCNLGDYFR (2)
TLGSCVGVKSGEKWRTARHHLEPHFSFPTAAS
MLSNCREMILNWARNLADDPMVTSKTRNGFDFDAVSACRQLPFRLIALALYKDMLTED
(0)
MFEQLWALNALHEKVTNIAFFSKWPTKSFYRWLPTEANSLLSEYEREWEKLNLKTIMEARK
(0)
TGKSCPAEVMYQGVEAGELTLDT (0)
YMQSLDEILFTNIDVTSAMMGYALISVAKNLEVQESLRSEILTVGKSAAEIAEYTRKE
DTILHKTYLEVLRNNPT (1)
WYSLPELTAIDKRIGGYLIPAGTAVVLDLQRLNKDSPVWQPDGSEFRPGRWDSISPVAARY
SLHGYGMGPRKCLGKNFANIIIKLLLVTTLEEFTLSAGTDETKLRK
DRFTRTPDDVVSFQVRRSGSK*
>CYP5243A1 Coccidioides immitis
31% to CYP590A1 Magnaporthe grisea
CIMG_01179.2 REVISED, EST GH367762.1
MASVSLTNIIFTSIILYIFTILLKLLQNYQRARKIGLPIVFVPVDQSNILWIIISPIVRPLLKRYLPRFIYNRIVICIFG
HEFHEKLEPFKNFVGGQKTYTLITLRGLEIWTCDPDVSMDVLRRPKDFSQLEIANKMMSKFGSNVLTTSGAVWARQRKII
ASVINEKISGVVFDESVRQTAGFIEEFGESKPGDIGSRSTKANRVIDGVTYKTFDMVKKITIHVLSRAGMGVTRHWRDDG
RQIKSSAAKADHDEDSRLKFDRALQMILANLVPATLVPEQILSHWPFFLPGAREMRDLASAVRHLPKMFRDMLGQEAPVT
DSFHGSSDKEPSTKINIISQLIAASELGNNQSVSTDANIKQGWTLSKDEIVGNLFIFNAAGFDTSANALSFALVVLAAYP
HWQEWLFEEIDQIVPEDSDASMEYSTIFPKAIRTLAFMLEVLRLFPPVIHIGKTAFSGNGEAVQLVNPMKKDGESAVTTE
IPSGVVIYINSAALHMAPE (0)
LFRPSRWINHSDNTIFQPPRGS
YLPWSAGPRNCPGQKMAQVEFVG (0)
ETDDEVRQRLERVIDGCRSKLTLEMEVYGVTDAEEEKGGRGVGLRWVRRKAPNRP
>CYP5244A1 Coccidioides immitis
37% to CYP596A1
CIMG_03163.2
MSLALDVITDSRVLVRLALLGAIFVLFRIYKSLIAPTKPWPNFPVIKLDGLDAATSWTEHALETIFRGREATNDGFFQII
TGNGPKIVAPNRFLEEIKANKDLDAQKGLDAQKAFSTEHFWTYSGMIGFKAMRNYPEPIRHVVRGKVNAAMLAMTKELAA
EAVAVIDASMPSKDAADDEWHSVSMQPVCEEIVARLSTLLFLGRDACRDREWLDVVRTYTFNAFRTSARLRACSPIWRPL
AHRFWFSESKMVRKQCAHADMMIKPMIEKRQKLIAAGEYKSLKVGDTLGWLLEASQRFGKYIDCVGSQMLLTLGAVHNTT
ETMNVAVLDICKNPDVVQPLRNEIVRVLKEEGGWTKNVFSKLHLMDSFLKESQRMLPLVIMQNNIAPLRRIVTRRTVLSD
GTVLPKGAFVTFAGNNMDPSVYPNPDVFDAYRFLRLRGKHNDGFQYTGLSTDMIQFGYGSWACPGRFLAVTELKLALVLF
LMEFDFCLDETSQEYVRHSAGANMSNRGATIKVRRRKEKEIDLMAMLE
>CYP5245A1 Histoplasma capsulatum H88
Supercontig 1: 6824213-6826226 –
ABRJ01000082.1 Ajellomyces capsulatus H88
118177-116161
HCB06665.1
MALLTAGLVPAKWLAADFIHQLSYL
QLACLVNTAGVVLLSIYCWFSAAKYPSIPRVRDGMKARFSLKTRLAYYTN
CEGLYKEAYET (0)
YLKKGQPCLVPGLGLRTEILLPKGTLRW
LVTQPDKVLNIQEAFREVDQIDWAADHHKYVTDPWLAM
ILNRDVNRNFDRYLGPMGKEMQNAVERWIPNKDEWEEIPLWDTLKLVIAQFSS
QFTVGEPLCK (2)
DEEYLRASSKFVDLFATNAGLVPFIPVPLRPVLCPLLYLPFRLNFWKLERILKP
VIKGRLDRFLKHQHSE
KIKSEPHHGINSGQNEPEDLLQLMLRFAQSDRSKE
DLHDLHSLAYRICINNLG
SFHQTTATATNLIFNIIASDKEFNTIALLREEIES (0)
KTGGWSKASVAKLVLMDSVMRETVRTHSFIHRSVTRT
VMDDNVHSPVIE
GEAGSGEASTISVL
LPKGAMVSILSRGSYCDPDIFDDPMKFNPWRFAQPKRDHNSEQSNGTGATPARPTFTVTSANNLFFGHGRHACP
GRFIADAETKMLLACLLMNYDVDLVPVPGPDGKGEVAVRPTSPWVLEVIMPPIGGRIRTKRRACERV*
>CYP5245A1 Histoplasma capsulatum H143
Supercontig
2: 2329560- 2331651 +
MALLTAGLVPAKWLAADFIHQLSYL
QLACLVNTAGVVLLSIYCWFSAAKYPSIPRVRDGMKARFSLKTRLAYYTN
CEGLYKEAYET (0)
YLKKGQPCLVPGLGLRTEILLPKGTLRW
LVTQPDKVLNMQEAFREVDQIDWAADHHKYVTDPWLAM
ILNRDVNRNFDRYLGPMGKEMQNAVERWIPNKDEWEEIPLWDTLKLVIAQFSS
QFTVGEPLCK (2)
DEEYLRASSKFVDLFATNAGLVPFIPVPLRPVLCPLLYLPFRLNFWKLERILKP
VIKGRLDRFLKHQHSE
KIKSERHHGINSGQNEPEDLLQLMLRFAQSDRSKE
DLHDLHSLAYRICINNLG
SFHQTTATATNLIFNIIASDKEFNTIALLREEIES (0)
KTGGWSK & ASVA
(sequence gap)
LSRGSYCDPDIFDDPMKFNPWRFAQPKRDHHSEQSNGTGATPAR
PTFTVTSANNLFFGHGRHACPGRFIADAETKMLLACLLMNYDVDLVPVPRPDGKGEVAVR
PKSPWVLEVIMPPIGGRIRTKRRACERV
>CYP5245A1 Histoplasma capsulatum G186AR
Supercontig 3: 1482810-1484825 –
42% to 623B2, 35% to 623A1
MALLTAGLVPAKWLAADFIHQLSYLQLACLVNTAGVVLLSIY
CWFSAAKYPGIPRVRDGMKARFSLKTRLSYFTNCEGLYKEAYET
(0)
YLKKGQPCLVPGLGLRTEILLPKGTLRW
LVTQPDKVLNMQEAFREVDQIDWAADHHKYVTDPWLAM
ILNRDVNRNFDRYLGPMGKEMQNAVERWIPNKDEWEEIPLWDTLKLVIAQFSS
QFTVGEPLCK (2)
DEEYLRASSKFVDLFATNAGLVPFIPVPLRPVLCPILYLPF
RLNYWKLERILKPVIKGRLDRFLKHQHSETIKSERHHGIDSGQNEPEDLLQLMLRFAQSD
RSKEDLHDLHGLAYRICINNLGSFHQTTATATNLIFNIIASDKEFNTIALLREEIES
(0)
KTGGWSKASVAKLVLMDSVMRETVRMHSFVHRSVTRSVMADN
VHSPAIESEASSGEASTISVPLPKGAMVSILSRGSYCDPDIFEDPMKFNPWRFAQPKRDH
HSEQSNGIGATPPRPTFTVTSANNLFFGHGRHACPGRFVADAETKMLLACLLMNYDIDLV
PVPGPDGKGEVAVRPKSPWVLEVIIPPIGGRIRTKRRACERV*
>CYP5245A1 Histoplasma capsulatum Nam1
Supercontig 5: 1478881-1480888 +
C-term has many frameshifts
MALPTAGLVPAKWLAADFIHQLSYLQLACLVNTAGVVLLSIYCW
FSAAKYPGIPRVRDGMKARFSLKTRLAYYANCEGLYKEAYET (0)
YLKKGQPCLVPGLGLRTEILLPKGTLRWLVTQPDKVLN
TQEAFRELDQIDWAADHHKYVTDPWLAMILNRDVNRNFDRYLGPMGKEMQNAVERWIPNK
DEWEEIPLWDTLKLVIAQFSSQFTVGEPLCK (2)
DEEYLRASSKFVDLFATNAGLVPYIPVPLRPVLCPILYLPFRL
NYWKLERILKPVIKGRLDRFLKHQHSETIRSERHLGIDSGQNEPEDLLQLMLRFAQSDRS
KEDLHDIHSLAYRICINNLGSFHQTTATATNLIFNIIASDKEFSTIALLREEIES
(0)
KTGGWSKASVAKLVLMDSVMRETVRTHSFVHRSVTRTVMDDNVHSPVIESEA
&
SGEASTISVPLPKGAMVSILSRGSYCDPDIFEDPMKFNPWRFAQPKRDHHSE
TFTVTSANIFF &FGHG & RHAC &
KMLLACLLM & NFDVDL &
VPVPRPDGKGEVAVRPESPWVLEVILPPIGGRIRTKRRACERV
>CYP5246A1P Histoplasma capsulatum G217B
ABBT01000025.1 Ajellomyces capsulatus G217B
HCB00156.1
468698 FFSPFRKVPGPILAKITGGWLLCVDLAGRRAMK
VHELHEKYGSVVQLGPNELSFSSAESIDMIYGTGTRFRKAPMYMTMGRPGVLHLSDPAAHRERRRLLNHAFSKQHLDDME
PEFRNSVKKIVARMERQGGEALDMKHWFKMYTLDNAGKAFLGATFGGLDSDESPRYVKDFDLFLLAWAFKSTFPIPAWFV
RKIPHPKIKFVFDAEARIYQYGIDRFNEYIEKYGRVSQRRDLLTKMIGRKENDPDALADSDIAVEISNLCFAATDTTGTA
LVYLFWELARNPHLAERLRSEIADLPLVDGVIQHQSVSNAPFLEALIIEGLRAYPPLPSGLLREAPVGGCVIDGIYVPQG
&
TIASTHTWTTHHSPEYFPHPDKFDPSRWLEGNVCDGMKKLWMPFSKGPRNCLGRT
MGLFEMKILIATLVRRFHISIDDTMRDDAMDITDHFLLIPKGDKCLLRFTPI*
467088
>CYP5246A1P Histoplasma
capsulatum G217B
ABBT01000049.1 Ajellomyces capsulatus G217B
The downstream PORTION OF THIS FUSION PROTEIN
resembles siroheme synthase XM_001935421.1
1:56 PMhis part has been deleted
35% to CYP5049A1
MPISLLISPNLTTIALLVGAVTTFSYTVSRFLHARLSCRHLPQPPHSFWFGHLLEVDKINRAYPTNVYIHHTLISLSRKY
DLPELYYLDLWPFASPMVVLCKPELAAQVTTEQAFPKDPAVGRFLSPFLGKSSIISVNGPKWKGLHSTFVPAFAPAYIRT
LADGMLEEILIYHDNLAKFAKSQECFAMASLSIDLTFNVIGRAVFNSPFHSEDGRKLVRNFKNGLDYAFDGVLSTSNWLI
GMVPKWILVWKVNRYIEKRVIMRFAEMKREEASSVKKSRSIMDLVLRQKLDNPMGIAGDSDFMEMAVSNIKTFLAAGHET
TAHTLGFIFMVLSKHPEVLKKAREEHDSVFSPDLNRTVEMIRAHPEKLNDLHYTTAIIKETLRLFPIGSVARAKGDESMN
IMYQGKPLEITDQLIMICILAMHYDSESFPSPCEFQPERFLTQTIPKDAWRPFERGARGCIGQELAMMEMRMVLLVVLRS
FEFESLGINPHSNQTASYTTLDMVYGDLVYQKQSLTARPIGGQDMKVKFAKGHQAYVNGN*
>CYP5247A1P Histoplasma
capsulatum G217B
38% to CYP587B4 Aspergillus terreus
HCB01044.1
MAITYGTPKLVAATGLAVFTASLVHFLARGIAARRRFYKMKARGIAIIEPYSPFLGHLPLLRSLKEGLPQDAHRVYTSIK
IVQNWQKYFPGAEKCPPLIYMDVWPFMAQPIIMVIDPELCSQLTQETPQPRHPIFGWALTPVTDGIDLISMNMPDHKIWR
SRLNPGFSSRNIIQNMPAALEEVSIYAQKLKDTADARSHEWGKMFPLYEGAVALTFDVVSRFALDLHPHEQTAGPGPLLN
ALRNLISRVKLKNVKTRLERLTPEFKSFVSQNAATMRDILFPQIQSRFSDTLDSKNQKTVIDLAIKDFKKSGQQPTPEFI
NILISNLKAFLFAGHDTTAQTICWIFYEINKNPDVLQRLRKEHDDVLGPDPKMAYQVLQQSPHKANELRYTAAVIKETLR
IHTLANTFRQGSPDFNFSLDGMLYPTYDCMIQTVPTMTHIHPDFWPHPTEFIPDRFLVPEDHALYPVKNAWRPFELGNTK
CIGQELAMLEMKLVLVFTLRELDFDFNYEQWDVVQKRDTTIVAADTINGERAYRCGEGIGTIKDGLPQNKTRDGEIERKR
KTNAHEIINGRKRGREGGERWMKTWT
>CYP5248A1P Histoplasma capsulatum G217B
31% to CYP660A2
HCB03239.1
MALYIPILVAVAVILLALAKIEQTPLIKTGYIEPPLVRVSLWQLWTHGTQILDQLAAKHIDDFPDGIFTVSIFGWKIYVV
NSPQLTLTIQARSKYTGLGWISVLVMASMGGQPKKATELLFKGVDRGDVGNGIGFVHDYHKVELRTMSLGNSLDAMRSDF
ATAWQPILESLRDSVNNGQKNVNIWHWLRMSVTVSVSRAVWGPTSPYCTKPELWEQFWTFNSGYNFLKYSFPRLFAWRGA
AAREKVVDAFVEYEKQGGFEHASALAQSRKAALDKTGLGIREVARMSLPQSVGQFDNAATVSFAVLSFILRDPKLQARIR
EELGPLTSTDHRGNPSVDLSRVELECPLLLSTFHEVLRLIAVGVTVRRVEQDYPLEVKTGGNQTQYFLRKGSFIWSSGIA
IHTSPKFYTNPEEFDPERFLGVRFPETQIPDIFRAFGGGGNICLGRHFARTIVPGAVASLLMCFDFEPVNGVPLCVPHRT
DLLLGHATPNPFGNTNINLKTRVLA
>CYP5249A1P Histoplasma capsulatum G217B
36% to CYP5183A1 A. niger
HCB07585.1
MTSPLVIALGLVPATYVFLSALLHLTQDAKEPPVIATQIPFLSPAVGFIMGMQKFLVKLRDKYNLPIYTLRLPGQRIYII
NSPALIPQLQRLIKTISFCPIEAQAADVVMGVGPEGNAIIGSDKMLDNDSYLSTFVPSIHPGLAPGPGLNAISSTAARGL
SESLEILSKSGPTTVDLYSWVRGEAFKAITESIYGPKNPFRDPALEEAWYTFEPGILPLMINIWPSLLARKSLHAREHLL
IPAFEKYFADKGHQQGSLLAQCRYEHNTSHGLRGRDIAATEIGQMIASLTNSLASAFWMVYHVYSDPIVLNECRAEAEQL
VELDDIDAQILDLAKIKSSCPILFSTWQETLRYVHIAVSTRVVMEDIIFDNKYLLKKGATVMTTSVVQNTDQSIWGPTLG
NFDHRRFVSQPGEKRKIPAAFRPFGGGSILCPGRHFVTAEVLSFVILLLLRFDLEPVTKDGKWFEPRREMTMTTSIPTPK
DRIHVKIVPREKQRGHVDISVSSKAAFY
>CYP5250A1 Histoplasma capsulatum G217B
ABBT01000198.1 Ajellomyces capsulatus G217B
37% to CYP582A1 Magnaporthe grisea
HCB05194.1 revised
273934
MDILKVVSISVVETYGFHIFDQVTTSFSRQVFWTLFIVQYAVLKIYWIWIYPLIASPLRSLPGPN (0)
YTQFLLGQTYNQITASCPNSIALAWMRKFPDADLIRYFAPGNHEVVLVNSPRAFREV
TFTHAYSFAKPRFFKRLVGDMIGGGLFFAEGDVHRKQKKLLA (1)
GPFLNQNVKHLLPVFEQNADELSSSIETLVVDSETGAIESKNW
(1)
FSCLISKSL
LDIISQAILGLEL
DGHSIASELGRCYHTIFSSTTMSRVMLFLNT
CVPVRRLLPVKTNREYTDANIEIKQILKKHVQQRTQEITS
LWRERLKSKNKDILTLIIQEQLKKSDECPEDEIVDH (0)
LRTFLAA (1)
GLETVGTAMLWAFHALASHQDVQDRLRNEINAAGDGKSSELKYSDICKLELLDHFVKEVLRCYPP
(1)
STCSMREAIHNVSICGQLIPAGTHVLMFPIMPQSNSIIWGRDPE
KFDPDRWKTLPTSARDGYTFQAFNTGPRACLGKSFAMLEVKVLVMKLVARWRFCHVSKPVVLQKIGLLFKPANGLELKIE
SAVLT 271867
>CYP5251A1 Kluyveromyces lactis
29% to CYP613B1, KLLA0C19206g
MLADILIPLIKKNWMAFVYFTPVLFVVLYLLKEWRAAYGFNNLGQTVAAPFGYERKTLPYNKENCARTKFLDGKSLSIKN
RDQCGDLYLQRSGTYKEIVLTTPKQLMEYYKSNSKNHSKLDSFGAGAFLVALLGECLGFQNGSEWLSMRKVFDSFFTHKA
AVENFPVMIDYISEWIKDLDTEQISDIDPLQLVSDLPFTCIAKYLYGSELCSKQFLQALKDLIPMHTELMHYSFLTVAGR
FKIFQYFPSKKMKQVSQFQRQFIDLSLKQVELSRQSGQETVVEKLYRHVESGKFTFNNWIQTIDEILFANIEVTSTVMAW
ALVEMGSNIEEQNRLRCEILKVKEQSSKDDFNKETDPMQRYMKLTDTYLQYCVWETLRMHPLLWFSFPEISSETLFIDGI
RISPNTPIVVDQYQINYNSPIWNPSDKPKDFGKKFAPSRFENITLRDALYSQVTFGAGSRKCLGRNFAELLIKSELAYIL
SKYKVTLTEKVEFSKDTFVVQPKTKIQLTAL
>CYP5252A1 Kluyveromyces lactis
28% to CYP578G1 (only a partial seq) KLLA0D11638g
MNVYSLFLALALDVVSGFEYGPQYSTNFITDLDHTREGKAHRNELFLGFQESSSMWFYTTLAPMLWDTVARWYGIGEKSA
KSQQWIWDKFQEALKPLQQGIIGSSTNDNTIVSPVGNVLSTMYDEKIGKGPISQTQFREIASEIADHVIAGHETTGITLT
YICWELSRPCNRHWQDKLFEECKTVPSDLQRLDQMPILHSIVQEACRLHSAIPGSEPRYVPQEGPKFEATLRDKHGTRVE
IPPGTIVSCQPWSLHLLETPFGANPRQFNPARWLRDETTGETEQEYEKRLTKMNNSMFTFGQGNRMCLGMNLALMEMKYC
IAQLYSRYTTDISPEWCNKVYQQQTDSLMGTSGRGRATSIKGTDVDMMRMADTYTTRPLMNECWLEFSSRD
>CYP5253A1 Mimivirus
called
Cyp51 by David Lamb, best hits are CYP51 but only at 23%
1 MLFELSIGAI IGFLTLYLLK RFNESKNFIT PDNLKKIPIV EGAVPVLGHG PAFSKDIMQF
61 MKNCYKKYGS VFQLKIFRTN MVVLCDRKLS EEFFKSREND MSLYDVLNRL
FFGLAFSDKP
121 DSLEFIIKMV KKTITIRYDD FAPKIMDEAQ
RLTKIMRESH SGKKLDMIPE IIKFVSRTSA
181 RCFIAMDIDD EFYDALNKFT NLLNKIVVLT
YFVPHWLLNA TLNRFMLRKY RMRMTKLLEN
241 EIEKYRTDLN KSDSLLFRKC VDHIDPETGA
TLTNQDIGDI VVCLLYVSSE NTSLLATNCL
301 IDLTLNPKYW DLIKSECSAM IALGDYKNLF
KAPLLNSIVM ESARLNSHVF ALARKPKTVN
361 RIGDYFVADN VDTISLCEPA LMKFEIASDV
YANPNSYDPV RFMAPRNEPK DSGHVMNWGK
421 GVHECPGKQF AIYEVKAAIA YIVTNFERFE
FNHNDLKINY FSPSAMCEKN ISVEFIPSQQ
481 NIHNIVYKDR TYIVEHIKCN ETSAWLIYNA
LDRQQQREYY QYTYEISTDS QEHKLIEKAG
541 PHKPFPIAYD KLVYTGQSNC MTPTKWYDFA SDIWELLTEN
YAELGFPIYD DKIRNFVPNS
601 FYGQLYSVES IMPTHRDQHV DYGLSISIGS
NCEFVIEDKT ILLPSGSVLI GDFSKISHSV
661 SKIFHEKPDH LSDFEFFNRV RFSAQIRSID
PDVQPLMTTQ EFLDMISEY
>CYP5254A1 Mimivirus
Mimi CYP
1 MVLSDILFSI YEHREKSPVF SWFAYLLRIL DWIIQFLSFG LIPSIGGDLY DLVDNGLFKF
61 VLDRNIQKKQ NQLYDKFRLG TVKMCLVFDG ELTKKLLLDN SIRRGGLYNL
LTKFFGKGIF
121 TSNIHSRWMK QRKAIFKLFS PQNLIQITPE
LTTSMFEELD RLITIKKDLD LVTVLSLIGL
181 VGFCKVIFGV DVTDMSEELI EPLNDLLIYI
NGAVEPVLIT ADPSYRRFIT NKKFVHNWMR
241 KLIDKARKSE NCFEIMRQQL DDIGSDDETE LIEFILSVVL
GGHETTARLM LGIIYSVCHN
301 KEIIEKLNNE TDEYPKGDYI NLKKRPYLNN
IIKEGTRLFP PVWLLSREAK NDTTIDNHFF
361 KKGTQFLISP LIILRDYNVW GSNAEKFDPE
RFSNMDPKSK ASKLYIPFIV GSEDCPGKKF
421 AILESAIVVS KLFKEYEITV LKHKLNPMSA
GTFRLSDKLP VSIKKLKN
>CYP5255A1 Fusarium oxysporum
30% to CYP606B1
FOXG_02898
MAFLVFLASLLLVMAWFGWQRNTKNNSFYETI
PCVGIRKDEWFAWTRAQLRSFSKTEEWMKEGYEKA (1)
TNLYKYSRNNQPFIIPSFRKGKVLILPPAQLKAIYNKRENELKAHDPASEALSFEWTIRNREVY
PSNYTVDVIRKWITKRFDELAAELQEELCLAVDEQFGMSQEWREVKLWPAVQRIFTRGLN
RVLVGFPLCE (2)
DEAFLETMRRFAIDMPFQGLFITLVPKVLRPIFAPLISWNARRDTEAGIRYCTPIIQDFLEANRNPTQEKP
(0)
INILQWIIEASAATGDPSQLDAHRIGHRIMILNFNLVQGGSIPFSTVLSDTCNGKHATSTFSQ
LRDEATSVLGSNKTWDRATISKLVLADSAIRESMRCSNFGLFALPRRVNSPGITLDNG
IQVPPGVHIEVPMHSIHMDNSFYADAGIFKPFRFADGTSMSR
SAVTLDESFLGFGYGKNACPGRFFGSHIMKVVLAYLVMNYDVEFGSEEPPMKTMWEYRIP
RESTAIRIRRRVQACN*
>CYP5255A1 Fusarium verticilloides (temp
5255A2)
Supercontig 2: 646261-647922 (-) strand
87% to CYP5255A1
FVEG_01765 and FVEG_01766 join
MATFFLFAFVLLVIGWFGWQRSTKNSSFYGTLPCVGVRKDEWFAWTRAKLRSFSKTEEWMKEGYEM
(0)
YSRHNQPFIIPSFRKGKVLILPPAQLKAIYNKREDELL
AHDPASEALSFEWTIRDREVYPSSSTVDVIRKWITKRFEEFAAELQEELCLAVDEQFGMS
QEWREVKLWPAVQRIFTRGLNRVLVGFPLCE (2)
DEAFLETMRRFAIDMPFQGLFITLVPKVLKPFLAPLISWNARRDTEAGIKYCTPIIQ
DYLKANQNSTSEKP (0)
VNILQWIIEASAATGDPSQLETHRIGHRMMILNFNLVQGGSIPFSTVLSDICNGAHAAST
FSQLRDEATSVLASTKIWDRATISKLVLVDSVIRESMRWSDFGLFALPRRVNSPGITLDN
GIHVPPGVHIEVPMHGIHMDESFYADAATFKLFRFADGTSPSRSAVTLDESFLGFGYGKN
ACPGRFFGSHVMKVVLAYLVMNYDVDFGDEEPPMQTMWEYRIPRESTAIKIRRRVQARN
>CYP5256A1 Fusarium oxysporum
31% to CYP65AU1 Coccidioides immitis
FOXG_14590
MNQLSMDWELVASTWQTASPASRVIVTLSTLSLTALLISIIYELYFAPLSKFPGPKLCAISRIPHLIATASGHQLPWLIN
LHNKYGGVVRIAPDALTFTDERAWADICGASKAAKDGMAKDPRLAALVGGDLVNPDPAKPRSQQTHSIMRKAMVPALKRE
NVKKLESMINGHIEEYLSALQKASERKEAVDMRDMNSFLICDLIADLFLGESLHLFTDPEFIPWVHSFDRFARGVTILAV
LNRFPFLHKFLLFAVHRWGSGERESFMAPIFARFDRRVALTSARHDMLQMVLDGDSEGTGRQGTMPLDLLREFAPFLMLG
GCEAMPTVLTGFVYFVFRKTSADIRKKLLEEVRGAFSSDSDITMDRISQSQKDLPYLEACLQESIRCYSPAATGTDRVVP
TSGAQIAGHFVPGNTVVMMLHQVTYSVKHNFSRALEYVPERWLPEGKGRPQDCIDDTEFLCIAAGVV
(2)
LSFYVLRLALCKLLYRFDIELTPESENWVEGQLTFGTRSKPPLMAYVKKASL*
>CYP5256A2 Talaromyces stipitatus ATCC 10500
ABAS01000009.1
66% to CYP5256A1 Fusarium oxysporum
462528
MESSVLRSPMEWMNIAVQAGSDSATVQYGLLFLLFIVISCLVSYV
462393
YEIYFSPLAAFPGPRLWAVSNIPYLIATASGKQVPILVDLHQKYGGIVRVSPGAITVTDE 462214
462213
RGWADICGSSKYAKDGMAKDPRLAALVGGDIVNPDPAKPRSGQTHAIMRRAMVPALKGEN 462034
462033
VRKLEGMINRHVEEFLTATEEGSRRPIDMRDMCSFLICDLIADLFLGESLHLYKEETF 461860
461859
RPWVHSFERFGKGVTILAVLNRFPYIHKILLFAIRRWGGKERDAFMQPIFDRFDRRVSLT 461680
461679
TPRDDMLQLILDGDGTKQGAMPRDLLREFAPFLMLGGCEAMPTVLIGFVYFIFRAES 461509
461508
AAIRQRLLLEVRSYFSSESDINMERVQHSQRALPYLEACLQESIRCYSPAATGTDRQVPV 461329
461328
GGAVIAGQYVPGRTTVNMLHQVGYYLTENFAKPYDFIPERWLPSESGRPSLFNDDKRTTLHPFSVR (2)
461131
LSFYTLRIALCKMLYRFDIELTPESENWLKGQVTYSTRQKPPLWARVKLARH* 460888
>CYP5257A1 Fusarium oxysporum
34% to CYP627A2 Fusarium sporotrichioides
FOXG_02736. EST CK615609.1
MMLNLPYSYTTLALFAVGLELLRRVLKALIFGFTGPLSRIPGPLWNKLSPLPWRLAFLKGTAP
FLAQDLHHQYGDVVRV (1)
TPNLVLVSDPVSVHRVLVEWDLHKSPLYEKYRQNPHVATLFTERDKAKYRIR
(0)
RRLLSNGFSMSYLKALEPLMHGCVQVLEDVLEDRCAAGGGTATVNIYDLLSSLAS
(0)
DIMAECSFGGSFGLVRQGHHPLKTRITNYMKKAALYQTVPLLSLFGKPRDEQLDAIVQ
GIIDKRLHSQKESERRDLLDMLLEASAENPDKLSMEDIKAE (0)
AAPSDTSAVTATFCLMKLLENPAAHQALKRELDELLASSSDPIVDENTHNLPYLNAV
IHETLRMLPPAAG (1)
GFARQALEPVTVGDYVLPAG (0)
TLVTADTTALHRDSRVYPDADKFIPERWISGHAGEKAAEKNWYPFSAGSRVCIGKH
(2)
FALKEVRLILAVLLRRFDLTIVPDQKIQYRHHSVLYIASGEYLVGVRKRVA*
>CYP5258A1 Fusarium oxysporum
35% to CYP65AB1, 37% to CYP562A1
FOXG_17730
MLSSFSFSSTSSWVTILGVTFIL (0)
CIFYIILHTIYNLRLHPLQKYPGPWWLAASRIPYTFYVLRGVAARKTKDLHHRYGHVVRISPDTLSFTSNRAWP
(1)
DIYGPGQPGGRGNIPKDSRYYPESHL (0)
KVFNDKTHRRLTQCHLTPSH
HEACLRKHTNLFISKLQQSQYQSETKEVDLSHWLHLLTTDIAGDVILGEKFGGLENGQCR
PIIAAIPCLARAFTSAVELTQYPGIRYMMNTFWTWFNRAPK
SPKTPMTVPKQTESHIKENKPISRILDGPEDQQ (2)
LSPVEKEAITMALIIAGSET (1)
TATLLAGSIYLLLKHQVYLKRLTSTLRTQFHTSSDMTLSALKEQQYLNAILKESLRLYPP
APGNLFRRTEKEGHVVMGEVIPSNTTLTMNIWAANRSALNFHLPDNMVPERWIQPRSAEY
QDDDRSAMRPFSIGPQDCPGRN (2)
FAWAEARLVLAYTLWNLDLELVSESQDWMTWQKVFMFWMKPPLRVRCTPAQTRVE*
>CYP5258B1 ABJE01000519.1 Verticillium
dahliae VdLs.17
44% to CYP5258A1, 42% to CYP562A1 Magnaporthe
grisea
45572
MEVKYVSSTEGPSSTTTLPWVPVAGVIAGT (0)
45428
VVLYVILTGVYNIWFHPLRAYPGPWWLVANRLPYTLSVLRGTATRRAKALHEQYGHVVRI 45249
45248
NPDTLSFTSGEAWR (1)
45138 DIYGSQSRCNPGIPKDPYFYMQHQGPANI (0)
STLNDDDHHRLRRV 44962
44961
QLNAFSPKALASHEVHVRRHASGLVSQLRSSADAKTDVDMFLRLELLVTDIISKLVLG 44788
44787
ESFCLLEKDDPQPGHFGVFSVLRNHTYAREMMHWPSIFRRAVVRFMTKRPATPNQTM 44617
44616
WMTRKATQKRFQQEGDEYDYISCMQRGSPKLR (2)
MSEDEI 44437
44436
RVSTTAFVIAGSET (1)
TATAIAATMYLLCKNPRVYSAL 44257
44256
THSIRSDFPLESDMTMPRLVQHEQLNNVLQEALRLYPPVPDNLFRRTADNASLVMGKVLP 44077
44076
PDTSVTMNVWAANTSALNFHRPDEMLPDRWSSSRPKEFEGDDRGVFNPFGVGPKDCLGKG (2) 43897
43832
LAWMEMRIVVAYLVWHFQFELTPESEAWMDGQKVFMFWEKPPLRVKVMKR* 43680
>CYP5259A1 Fusarium oxysporum
36% to CYP530A11, most similar to pseudogene CYP530A6P,
52% to C-term
FOXG_11876 revised
MPSRELTIGLAVLSLLLVLVQKAITRRRESKALLPLPPSP
PSTNIIAGHLPTVLKAAKEHRQHLLFQKWAEEYGEVFFVQ
LGTIQEYFINSDQAVRAIFDKAAAQTSERPRWIVSNEQICNR
LNLLLLSSSEKAWKSQRKATTFGLTNLNLADAGLPFLHFETLKFLNDIA
QNPNKGADPQSLWSSIGRYTYSTFSSQIFGLDVPDDNSPVIDYIFETGL
AQILGMLPGYYLVDTFNILDKLPLFLKPWERDAKSRHKRDYEWCCDKLE (0)
RVKSLIDAGEAPPHMTFIRRVIEDPNHLGLDSLEDAAYLGMMLIIGASDT (0)
SRISTWSFLEAMLTFPNVCNKARKVI (1)
DDAVGDRVPVYEDLERVPYIRQVMKESWRWRPPVAL
GHPHTTTRDIIYKDYRIPKGARIHLNAW (2)
AIHRDPKRYPDPDRFIPERFEGDTRS (0)
SQESAASPDVSKRDHFVFGAGRRIC (1)
SPGYHVADRSFAVSVMRILWAFDISLKPGTKLPLDPQSFPGDMPGNPGL
DLPVSLTVRSPERLATIQKEFEGAVQGRAKMEPLAG*
>CYP5259A1 Fusarium verticilloides
Supercontig 14: 11152-13123 (-) strand
92% to CYP5259A1 = ortholog
FVEG_09969
MLSREMTIALAVLSLLLVLVHKAISRRRETKGLPPLPPSPPSTNIFAGHLPTVLKAAKNH
RQHLLFQKWAEEYGEVFFVQLGTIQEYFINSDQAVRAIFDKAAAQTSERPRWIVSNEQIC
NRLNLLLLSSSEKAWKSQRKATTFGLTNLNLADAGLPFLHFETLKFLNDIAKDPNKGANP
QSLWSSIGRYTYSTFSSQIFGLDVPEDNSPVIDYIFETGLAQILGMLPGYYLVDTFNILD
KLPLFLKPWERSAKARHKRDYEWCCDKLK (0)
RVKLQIDAGEAPPHMTFIRRVIEDPNHLGLDSLEDASYLGMMLIIGASDT
(0)
SRISTWSFLEAMLTFPDVCNKARKVI (1)
DSAVGDRVPVFEDLDSMPYIRQVMKESWRWRPPVALGHPHTTTRDIIYKDYRIPKGARIHLNAW
(2)
AIHRDSTRYRDPDNFIPERFDGDTRS (0)
SQESAASPDVSKRDHFVFGAGRRIC (1)
SPGYHIADRSFAVSVMRILWAFDISLKPGTKLP
LDPQSFPGDMPGNPGLELPVVLTVRSPERLETIQKEFEAAMRNRERMEPLAG*
>CYP5260A1 Fusarium oxysporum
33% to CYP5095A1 Aspergillus oryzae, 34% to
682D3 Uncinocarpus reesii
FOXG_12398
MFRVSDIGSSIDRTKLFQYLVIFFVSFKAITYIQRLFFHTLSKFPGPRI
CAASRLYEFYWDSYQHGRFWAKLPDLHRRY (1)
GPVVRIGPNEVHIEDSEYFDTIFGFRPLNKEAMMAKEFGINHALFGVEDY
KTYVKKRAAFGNAFSRTRLSKIQGQINEEIQKGCTWVEENSKNGGPVDLA
FLFRAVPAEIITKYLFGQEYGFLQHVQTTK
NLYDKRMDRLFGFSHLGRFIPKEIPLFLSLFRQLILRALGYNDPGSAFLDYFL
LAKKLVQKVVAQHNHSNRNAEGITQHT
VFDDFLDSSLPQEEKEKGPLTQQAVAIWSGGWDTVGFVLTMAAYQLLQNPQVEQRLYQELKEAWKDPTEPPEITTLENLP
YLTAVVKETFRLSPGALCRLSRVNPGGFEQYGDWEIPPGTIISMSIPDVLSDEAIWGSDAAVFKPERWLSGGADLDRYLV
TFSKGTRVCPGIELAWIETRLVIASLFRRYEMSIAAEAGISDDDIMPYYEGFTPAVKNWISRLPVKVKPRD*
>CYP5260A1 Fusarium verticilloides
Supercontig 15: 1333668-1335368 (+) strand
91% to CYP5260A1 = ortholog
FVEG_10960
MLRISDISSSIDRTKLFQYAIIFFVSFKIITYLQRLFFHPLSRFPGPRICAASRLYEFYW
DSFQHGRLWAKLPDLHRRY (1)
GPIICIGPNEVHIEDSQYFDTIFGFRPLNKEAMTAKEFGIDHALFGVEDYKTYVKKRAAF
GNAFSRTKLSKIQDQINEEIQKGCIWVEDNSKDGGPVDLA (2)
FLFRAVPAEIITKYLFGQEYGFLQHVQTTKNLYDKRMDRLFGFSHLGRFIPKEIPLFLS
LFRQLILRALGFNDPGSAFLDYFL (0)
LAQKLVQKVVAQHNHSNENSESVPQHTVFDDFLDSSLPQEEKEKGPLTQQAVAIWSGGWD
TVGFVLTMAAYQLLQNPQVEQRLYEELRKAWKDPNESPEITTLEGLPYLTAVVKETFRLS
PGALCRLSRVNPSGIEQYGDWEIPPGTIISMSIPDVLSDKAIWGSDASVFKPERWLSGSA
DLDRYLVTFSKGTRVCPGIELAWIETRLVIASLFRRYEMSIVPEAGISDDDIMPYYEGFT
PAVKNWISRLPVSVKPR
>CYP5261A1 Fusarium oxysporum
35% to CYP630D1 Aspergillus oryzae
FOXG_09802
MFSLPINAAELAFLIPLTLVAFLVLKPLLYYLLDPLDL
RKYPSPSFLAATTHFWILKETWLQRRSRSIHRQHERLGDVIRIAPSLIIFNIPKAVPDIY
GHAAARKLVKDTFYDKISGEERDIVNVIDHGDHSQRRKYLSNSFALKTVTD
MEPVIGQNFQRLLDHLDGVADQSTNIPSGQTIDIRRW (2)
FNYFTLDVIGDMAFGLPMGFLGNGGDATRVKSAGRQEYCIPST
IDTLHRGTRLSTTLAQLSSIRCVKLVKRLCNTTNWLKQSTGAQGIEDFDNVCIDQLSERLGNGSPDRSQQDFMSKILKDR
EGKDRGLSFERLLSESIVFMNAGSETTAAALSSTLYFLLSNRKCFEKLRAEIDARLGPNHNGIVSYDSAKDLPYLRACID
ESLRLRPPIAYALQRLVVCPQGAIIAGHHIKQGTTVAVSPWTIHRNRKLYKNPDEFDPERWFDPEQLSNLRRYYIVFSQG
PRQCLGRHIAIVELQILISTLVRRYNMYLADQEMNFVIFDRFNSNPGPLSVKVERRVFVD*
>CYP5261A1 Fusarium verticilloides
Supercontig 11: 1036601-1038275 (+) strand
86% to CYP5261A1 = ortholog
FVEG_08678
MFLLSINAADLAFIVLLALIAFLVFRPLLHYLLDPLDMRKYPAPSFLAATTQWWILKETW
LQRRSRSIHDQHERLGDVIRIAPSLIIFNIPEAVPDIYGHAAARKLVKDTFYDKIAGKER
DIVNVIDHGDHSQRRKYLSNSFALKTVTDMEPIIRQNFQRMLDYLDEIATQDTASQA
LDIRRW (2)
FNYFTLDVIGDMAFSLPMGFLAGRCDTTRVKSPGRHEYHIPSTLDALHRGTRLSTTL
AQLSSIRCVKIIKRLFTSTNWLKQSTGAQGIEDFDNVCTSQLTR
(0)
RLNNGSPDRLQQDFMSKILTNREGETRGLSFERLLSESIVFMNAGSETTAAALSSTLYF
LLSNPKCFEKLRGEIDAKPGSSNEGIVSYDSAKDLPYLRACIDESLRLRPPIAYAQQRLV
VCPQGAIIAGHHIKQGTTVAVSPWTIHRNRKLYKDPDEFDPERWFDPEQLSNLRRYYIVF
SQGPRQCLGRHIAIVELQILISTLVRRYDMYLADQEMDFVIFDRFNSNPGPLPVKVERRVFVD
>CYP5262A1 Fusarium oxysporum
34% to CYP625A1 Fusarium graminearum
FOXG_13424
MPSPPEHTLFYTLTVQALCSTLAVVFIVLIYAWLAYLLGNGSLRHVPGPWYCKVSNIPLSIYEILCRRSDIILDLHKKYG
PVVQIAPNEVSVADLEATKQIYGTKDRWAKSDYFDHFMGYGRRSIFATKPYEDHRIKRKYTSSFYQAKAIYKLPEIEEHI
KSRSLAVLDQVRNGEDVDALSLTSWYALDNITFLVLGPNHGTHSVDQTCTERGILEGLKYQQFIGPFRYRCPRLYNYASL
LLQRASSRFRYLSADGKFPTWCEKKLFAALKDPRLNETHSLVRHLWELKQDDTNTGSIDVPYMAAEVLDNIDAAEATIGV
TATYLIWKLTEAPEWQDKIRQELSALPKQDDGCPSFADIDTRVPSLEACLREVYRLHPSSSGKNERLVPLGGCTLAGVFV
PEHTVVTSSVLALHYDGEVYSDPDRFLPCRWIDGSEEQRKVLDAQLIPFGYGGRVCLGKALATMELKLLIASLYLEHESL
ATLATNAVSMKQCSTHDAVPRGLECVVRFRRMKDNATLE*
>CYP5262A1 Fusarium verticilloides
Supercontig 18: 139667-141223 (-) strand
86% to CYP5262A1, no introns, probable
ortholog
FVEG_11855
MTSSSEKTLFYTLTIQTLFLTLAVVFIVLICAWIAYLLGNGSLRHVPGPW
YCKVSSIPLS
IYEILCRRNDMILDL HKKYGPIVQVSPNEVSVADFEATKQIYGTKDRWAKSDYFDHFMGY
GRRSIFATKPYEGHRIKRKYTSSFYQAKTIYKLPEIEEHVKSRSLSVLDQVLNGEDVDVF
SLTSWYALDNITFLVFGPNHRTHAVDQMCTERGILEGLKHQQFVGPLRYRCPWLYNHASL
LLQRVSSRLRYLSADEEFPAWCQKKFFAALKDLQLHESHSLVRYLWELKADDAHNGSIDV
AYMAAEVLDNIDAAEATIAVTATYLIWKLTE APEWQDKIRQELSVLPKQDDGYPSFADID
TRVPSLEACLREVYRMHPSSSGKNERVVPLGGRALAGVFIPEHTVVTSSVLALHYDGE
VY
SDPDNFLPRRWIDGSEEQRKVLDAQLVPFGYGGRICLGKALATMELKLLIASLYLEHESV
ATLATNAESMNQCSTHDAVPRGLKCEVRFRKMKDNVALE
>CYP5262A2 Fusarium verticilloides
63% to CYP5262A1 Fusarium verticilloides
FVEG_06501 revised, not found in the F.
oxysporum genome
MLSTTASNIQGYLPSTEALWLGLIVLSVLLSYAWLLYPLLHGRFHHIPGP
WYCKISSLPLAFYDISCCRNEVILSW
HRKHGPVIVIAPNEVSVADLEGTRDVYKATGRWAKSSYFDHFQGYGMR
SVFATKPYEEHRKKRKYTSAFYQASTIYTVPEIEQHIKARSLAFLNQVGAG
QAVDVYSLTSWFAFDNITFLVLGPEYSTCSVDQLCPERGILAGLKSQQF
FGPFRHRYPQLYKFVSRILQTLSSSFYYLSADDALALWCQQQFYTVAQD
PCLSKSHSLVRHLLETEEIEADEGPAYLQYIAAEVLDNINAAEATVAVTAT
YLIWTLTQVPHWQQKIRRELSVLPRMDNGSLSFSDIDSQVPSLEACLREVY
RLYPASSGRAERIVPHGGRDLSGVFLPQGTIVTSSLLALHYDPQ
VYPDPSSFSPERWLEGDEKSQKLSDRYLMPFGYGGRLCLGKALATMELKM
LIASLYLEHESLPTTMTNAGTMKQCSTHDAVPKGLRCVVQFRKTELSN*
>CYP5262A3 Neosartorya fischeri
56% to CYP5262A2 Fusarium verticilloides
NFIA_044250
Note: this seq does not have an ortholog in A.
fumigatus
MLSAALELVREWVPFLRTWFFVALAIVSLLTLGWVLYHRYRFGRHVPGPWLPKVSGIPLAWYDIWYCRNDHILQWHRQYG
PVVCIAPNEVSVATLESTKDIYGTTLRWPKSNYFDHFKGYGMRSAFATKPYEEHRAKRKLISAFYQPTTIYKLPQIEHYV
QERSRAVLREIQHGQGVDVYSLTDWYALDIITHLVLGPDFGSRAIECPCPERDILALLKHQQFVGSLRMRYPNAYHYISC
IFGKLTPRLRYLQADNEFASWCKQRTLGAMEAPSMSNSPSLLRHLLEIRGSDGEKKKQQLDREYVVAEILDNINAAEATV
SVTATYLIWRLTEAPEWQRKIRKELTALPVQPDGSLAFADLDSHVPSLEACLREVYRLHPASSGRAERVVPQGGHVLCGV
FLPQGTIVSTSVVALHRDERIFPDPDRFNPGRWLDEDPLTLKMREAQLIPFGYGARICLGKALATLEIKMLIANLYLRYE
TVMGSSTTPESMKQCSTHDAVPKALKCVVRFQEVAEEL
>CYP5263A1P Fusarium oxysporum
45% to CYP639A3, 41% to CYP5100A1 Aspergillus
flavus
C-term pseudogene fragment, no upstream P450
sequence is found
FOXG_15578, FOXG_16037 identical sequences
SIAGWTFPKDQPIMISTFDTARKPSVWNQGTPDEPHPVDEFWPERFIVEP
KDPTSGPTLSQTRLPETKDEWSKPYFTLDGTVGSWIPYGGGSR
MCPGRHFAKKELIVTMAMFLTAFDIELEPRDDWIRNDAKYFMFGVMHP
KGPIPARVRRRTPNV*
>CYP5263A2 Botryotinia fuckeliana B05.10
XM_001549031
47% to CYP5263A1P in C-term part only
weakly similar to CYP639 family mainly in the
C-term part
MKLLDNLYLYEGWKAMAFSACLLPFLVSYLVTTIKSVIAVRSKN
NDKSPAIDPSADFIFGNLLAFSFDTRGYMAHLIERFGPHVPVRIRVASDSFYFVSGPE
YILKLFRGSRDLTAIPAMAAIVERIFGAPPEASSVLLDDNTGTSPKPLLDSNPLPGDQ
RYHHISHHAYTDNLTGVRLAEVVARFLTNLGTELDKIGVVGGPLKGIPRFFIPDAYRI
RDKMVKSILEWHRSAEAHLDHSDKELDKTSWEPYYGSRLFRNRARHLSKINGFGDQAR
AANDLGLIWGANSNSIPAIAWCILDIICRPDLLSQVQAELASIEKLHPTANFDQRMPD
LLSNLLLQSIYCEELRLRNAAALQRSTVSSNFKLGPWKFPKEAMILASIWFAGHDKNV
WNEGANGEHDVDSFWPERFILYPNNPYSGPRKSDSGKHPSEKIAKPKLTTDTVSGSWI
PYGGGQQICPGRFYAKQESIGSIAMFLSKFEIELTGNKNPEPDFKYFSLGVLPPKGKF
PARLRRRLGKVAE*
>CYP5264A1P Fusarium oxysporum
36% to CYP633A1 Fusarium graminearum
note CYP561E1 is about 3000bp downstream
PERF in green, no heme signature, probable pseudogene
FOXG_17452
MLQQQHAASDRELPTAFLIGLLTVTIICIAALERVTRVSVESREPPLLKPRIPIFGHILSFIRKPSEYFIELRQKHNVEV
ATLQLGHAKVYVVWSPAVVQSAFRSKALSHDKYSLDFAQKVFGLSKETIISLRSPEAVQERIQQRLIEAIHEGLIGQSLR
NMTARALDYLNEQVSSLAVDNQRLEIPNLYVWLRNHITLSVSNTLYGAKNPFREDPSLIQSLWDFEGDFTRLLLGSFVGK
FLAPGAFNGRRRVQSAMIDFYASNSELNDDVTPFIRARAQLLRQAGIPAEEIGRMEMSFMFVATTGSVPTIFWLLANVLQ
DQNLIQELRMEIEPLVLRERNVAELRVSAINENSCPLLISCWHEAIRISNQFLGTRHPLEDMIVSNKEGQNYLLKKDVPV
IWTARALHASTDAWGGDATTFRGDRFVNLQGKDKQKKKASFVSLK
(missing the heme region here)
PASVKMGPTRLGEGVMKPLHEGQDSSCMVKRREGWETVGWRMVF*
>CYP5265A1 Fusarium oxysporum
39% to CYP609A1 Magnaporthe grisea, 39% to
CYP5193A1 Mycosphaerella graminicola
FOXG_17455
MALFYVNTSWYLAILSTALIAIIYLFALFFHRPQFPKGAPPRSFEDWPIIGSPQFFTQHGDFNLRGL
AMSASNHFSFYLGKHQVVSIGASGRKTYFENHHLNAGEG (2)
YAALFTGTPHRQSGAEVAIDNGEYQSKFGKTLILLFKKAYLSRRTPILAADVKGI
MESLIRKASNQNATMKPFEDIYRIVWQQTNRLVGADEIAASPEKLDHIMRLFEDISQGASPLRVMFPMLPTFDHIKRTVA
GARLYGMLQGLVNDRKRLGRQEDDALQFLMDAGEDIAGITGFLAGGLFAGQLNTGVNAAWLLIYLATNKTWYNKIQKEVD
SVLARHGVDQRRETCKIIDILSRFGLEEWISEFPLIDLCLKETIRFQLPGTFCRKNTSDKSITIVGSDEIIPKDAFAVYL
TDNCHFNPDIYSEPLKWDPDRYATGRAEDKKGQYAYLGWGVGRHSCLGMTAARMEVTMVVAFFVTLFDFHLLDEKGKRTD
TVPMPDRNRFGAGKPKNWNPQLKYTLRS*
>CYP5266A1 Fusarium oxysporum
no gene model
Supercontig 19: 668959-670705 (-) strand,
frameshift
MAVDLATTVQAFLPRVVVYTIIGTTAAWLLHLMQPAFQAALSKDYQKFNWAGDTK
&
SVGIFMKASYEVALKSQEYFKETHRK (0)
ILEAGHGGIQLVPILHCSTGFMLMVPKQLLNEYVKQPENDISLKRYTLQALVPDYTTLGP
HIVIHPVYRNVVHKELYQKVADKMPMVNEEMKAALDDNVASKLDSNGVVQINMWDTASAI
LSRSANRIISGQPLCDNKEYRDATAEYAATFFASALYARFIPPFLRP
(2)
LLLPYMCRPLMRCIETAAKHATPVLKERMAIIDAAEEKDIEPDLP
(0)
NDMLSAIILAAKKDPNGPSEYEPMVIVARMMVLNFVQSYTNLVTMTNLV
YDLISLPAGDYEAMISDLRAEISQEMAKGDAFSHEFFQRLPLMDSLIRESIRYNPIGETG
IERAVGKQGGFTFSNGIHVPQGAILAAPIKAYQRDERTYPGGFNPRRSMEDPEHPRMTDI
SPDFLNFGLGRGACPGRFFTSNLLKLTLTHLLMDYDFERLDERPENVRKVTIDEPCGRFL
ITLKKRNHA*
>CYP5266A1 Fusarium verticillioides
28% to CYP5195A1 Mycosphaerella graminicola
Supercontig 19: 108020-109773 (+) strand,
& = frameshifts
97% to CYP5266A1 Fusarium oxysporum = ortholog
FVEG_12216
MAVDLATTVQAFLPRIVVYTIIGTTAAWLLHLMQPAFQAALSKDYQKF
NWAGDKKGVATFMKASYEVALKSREYFKETHRK (0)
ILEAGHGGIQLVPIPHCSTGFMLMVPKQLLNEYVKQPENDISLKRYTLQALV
PDYTTLGPHIVIHPVYRNVVHKELYQKVADKMPMVNEEMKAALDDNVASKLDSNGVVQINM
WDTASAILSRSANRIISGQPLCDNKEYRDATAEYAATFFASALYARFIPPFLRP
(2)
LLLPYMCRPLMRCIETAAKHATPVLKERMAIIDAAEEKDIEPDLP
(0)
NDMLSAIILTAK & KDPSA &
PSEYEPMVIVARMMVLNFVQSYTNLVTMTNLVYDLISLP
AGDYEAMISDLRAEISQEMAKGDAFSHEFFQRLTLMDSLIRESIRYNPIGETGIERAVGK
QGGFTFSNGIHVPQGAILAAPIKAYQRDERMYPGGFNPRRSMEDPEHPKMTDISPDFLNF
GLGRGACPGRFFTSNLLKLTLTHLLMDYDFERLDKRPENVRKVTIDEPCGRFLITLKKRNHA*
>CYP5266A1 Gibberella moniliformis 7600
chromosome 4
AAIM02000163.1 EST DR645966.1 Gibberella
moniliformis
Seq in () fits EST, & = frameshifts
97% to CYP5266A1 Fusarium oxysporum = ortholog
21766
MAVDLATTVQAFLPRIVVYTIIGTTAAWLLHLMQPAFQAALSKDYQKFNWAGDKKGVATF 21945
21946
MKASYEVALKSREYFKETHRK (0)
ILEAGHGGIQLVPIPHCSTGFM 22125
22126
LMVPKQLLNEYVKQPENDISLKRYTLQALVPDYTTLGPHIVIHPVYRNVVHKELYQKVAD 22305
22306
KMPMVNEEMKAALDDNVASKLDSNGVVQINMWDTASAILSRSANRIISGQPLCDNKEYRD 22485
22486
ATAEYAATFFASALYARFIPPFLRP (2)
LLLPYMCRPLMRCI 22665
22666
ETAAKHATPVLKERMAIIDAAEEKDIEPDLP (0) 22758
NDMLSAIIL(A)AK & KDPS(G)
&
22821
PSEYEPMVIVARMMVLNFVQSYTNLVTMTNLVYDLISLPAGDYEAMISDLRAEI 23018
23019
SQEMAKGDAFSHEFFQRLTLMDSLIRESIRYNPIGETGIERAVGKQGGFTFSNGIHVPQG 23198
23199
AILAAPIKAYQRDERMYPGGFNPRRSMEDPEHPKMTDISPDFLNFGLGRGACPGRFFTSN 23378
23379
LLKLTLTHLLMDYDFERLDKRPENVRKVTIDEPCGRFLITLKKRNHA* 23522
>CYP5266B1 Penicillium marneffei ATCC 18224
XM_002149609
48% to CYP5266A1 Gibberella moniliformis
ths genbank predicted mRNA seq has a missing region at the
EXXR motif
due to a frameshift and removal of an intron that is
incorrect
MAEGYTQIFQSGPLLMVMASLITGLAWLFYLIQPALLASFSAKY
GSFRWVDGSPGFLEFIELSCKCVFHAGELFTVAYKLLKTANGLLLIPFPHSPTGFLLL
LPKELIAEYARQPESIVSFHTYVRNAMHAKYSLFGDNVLDNNIQKPIVYRELFQKLPD
KMDMMNEELVMAINDGVTANLDSHGEISINMWDTATAILSRASNRIIAGHPLCRNQEY
LDAAVHYAVSMFSLAVYLRFIPPFLRPLLASLVRRPLSRDRDIVAKHAIPVIEERMKM
IEEAEIKGVEPKLPNDLLSAALKVARKDSNSKLEYTPMMMVNRILAFNFLQSYSNTLT
VTNAVYDLTSLPQAEFDRTVTDTRAELSWELRRPNAWSHDFVN
&
MDSFIRESLRANPIGEVELERTIT
SKDGFTFSNGLHVPHGAILAAPLKAIQQDPANYPGGFNPRRASEDLIRPTVTTITPVF
LNFGLGRPACPGRWFAVNMQKLTLSHLLLEYDFQRVDARPPGVRKGTLVEPCGRSKIT
LKRRIVVDQ*
>CYP5266B2 Talaromyces stipitatus ATCC 10500
ABAS01000014.1
81% to CYP5266B1, 50% to CYP5266A1 Fusarium
oxysporum
513492
MEEKHIQIFQSA
513504
PLLIGLAALTTVLAWFFHLIKPALLATFSRKYSSFKWVEERRGFFGFIRLSYKCVFHAKE 513683
513684
LFTVAYEK (0) 513707
513766
LRNTASEVF
513793
LVPFPHSSTGFLLLLPKELIAEFARQPESIISFHTYVRNAMHAQYSLFGDNVLDNNIQKP 513972
513973
IVYRELYQKLPDKMQMMNEELVLAIKDVLDAKLNEKGEISINMWDTATAILSRASNRIIA 514152
514153
GDPLCRNQEYLDAAVHYAISMFSLAVYLRFIPPFLRP (2)
514315
LLAPLV 514332
514333
RRPLSRDRDIVAKHAIPVIEERMKMIEDAEIKGNKPKVP (0) 514449
514521
NDLLSAALKVARKDPNSKLEYTPMMMVNRLLAFNFLQSYSNTLTMTNAVYDLISLPPEEF 5147
514701
ERTVTDIREELTRELKRPDAWSHDFVNRLVVMDSFIRESLRANPIGEVGLERIVTRENGF 514880
514881
TFSNGLHVPRGAIIAAPLKAIQQDSANYPGGFNPRRALEDPTHPTVTTISPVFLNFGLGR 515060
515061
PACPGRWFAVNMQKLALGHLLLEYDFQRVEVRPLGVRKVTLVEPCERSKIVLRRRSVG* 515237
>CYP5266B3 Ajellomyces dermatitidis ER-3
cont1.288
ACBT01000288.1
64% to CYP5266B1 Penicillium marneffei, N-term
not clear
447023
IAGWLSQPWHVFLLQAVAGTFLITFAACLVHLLEPALLASFSPKYDGFTWVTGERGLGNF 447202
447203
FSVAYDCVFDAGSLFKVAYQK (0)
447265
VRNTGSE
447352
IFLTPFPHSNTGFMMLLPRQFIAEYARQPEAIVSFNKYVRDVMHPKYSLFGANILDNNLQ 447531
447532
KPIVYRELYQKLGNKIEMMSTELVGALNDVLLPQLDENGEMKINMWDTATKFLSRTSNRI 447711
447712
ISGYPLCRNQD & 447744
447744
YLDATVHYAVNMFSRAVYIRFIPRFLRP (2)
LLAPLVRRSLSRD 447923
447924
RKIVAKHAVPIIKERMRILETAEGKGIEADLP (0) 448019
448072
NDLLSQAIVAARREKHSYIEYDPMQIVSRLLAFNFLQSYSNTLIMTNCIYDLISLPKG 448257
448258
VFEETVADLCEEINRELAKGDPWSYDYIKRLDVMDSFIRKSLRANPIGEVGLERTIMSKE 448437
448438
GFTFSNGLHVPQGTTLAAPLKAIQRDKDNYPSGFDPKRSLRDPAKPKITTSSPEFLNFGL 448617
448618
GHPACPGRWFAASLQKLAFSHLLLEYDFVRVDQRPPGVRKVTLVEPCGRSLITLRKRKAT* 448800
>CYP5267A1 Fusarium verticillioides,
Gibberella moniliformis
33% to CYP596B1 Nectria haematococca
FVEG_05584 not in F. oxysporum genome
MASLSYVLSLLQGVPIAAQVLTIIAAIPLAIYAYDWLRKERLFPGYPLISLDGKTPEESWINFPKETLVKGAQLCPDSPF
QIASYTGPKLILPQKYAEEVRVAENAHFTKSVTADLPWSLPGFKAFQLQHDHDRVLPTVVRTKLSLSLNQLTKGIVEETL
SVIEDLFGEQTRGGEWQTISIRGAAMQIVAQNTLRIMVGEKLCRDPELIDIHTRHAGAIFAAGSEIRAFPTALWPIVHWF
LPLPQQLRKQLKRAEEIMGQEVRRREQEARTAIASGKKMAKFGDSVAWHVDVPTSLGVKDYDQTAGQLAFTMAALHNTST
QLGGVMWELCEHPEWIDILRKEVISLVTEMGWTRQTLAKMDLMDAFFKETQ
&
IYPRPLTTVRRYAEKDLVFHDGLTIPKGRRFFLMPLIRIDKQGEFDPYRWVKRRET
SDDPKGLLFVAAGLESQTFGLGKHACPG (2)
RFFAHDEMKVATALLILKYDWRKLPTTPKPYFGAKEDVAVFPDGVELEIKARKPEVDLS*
>CYP5268A1P Fusarium verticillioides
38% to CYP592A1 Magnaporthe grisea, pseudogene not found
in F. oxysporum
FVEG_03368 revised
VDSMPFLANLPEALAHFKKEGRRLHEEELSLFRELQSDVRRALEKGYDTQSFTRTFLENRD
SYQLSDDEAAYVIGTLFEAGSGTTAAAMMSYCLTM*YFPEWQKKMQDELDEQ
VGDRMPEFEDIPNLPTVRAVIKEVLRWRPVTAG
GFPHQLTKDDEYEGFIFKKGTIFHPNQWAIHGDPTLYPGPNNFRPDRWLDPQFPTTYKEP
LSKFPNLQNYSCFGFGRRICPGQNIAERSLHILTARVACSGSIIKKRNVNGMELPLPLY
DYTKGFNIQPEHFDFDIIPRPQARLAAIRESLREAKSKWPA*
>CYP5268A2 Aspergillus terreus
69% to CYP5268A1P
ATEG_01068.1
MPTHTQEDPSQVLQVGVQLLLLRSPMTDTFPGKPFVGNLLDIPKVHSWLRFKEWADEYGPIFQLNIAGRKHVVISQEKIA
NDLLRERGSLYSSREYLPFASGLLSDNLRPLLLPYNDRWRRGRKLMHQLTTTTVVTSYEPVQDYESKRLLASFLKAPRDY
EKWFERYACGVVYRLGFGRWIETGQETDFRRIVHVGKEVERVASPGQYL VDSFPFLMNLPLPLAPFKREGARLHAEELSL
FRKLQQDVRDALERGDSVKSFTRTFLENQKTFRLSDDEAAYVIGTLFEAGTGTTAAAMMSFCLAMCHHPEWQTKMQAELD
RQVGDRMPEFKDLPNLPTVRAVIKEVLRWRPVTAGNVPHQLTQDDTYQGHFFPKGTVFHANQWAIHRDPELYPDPENFRP
ERWLDPSFPTYREPLTQFPNMQNYSCFGFGRRICPGQSIAERSLNILTARIAWAATLSRKKDADGNLMLLPLYDYCPGFN
VQPNFFGFDVIARSPKRAEQIAAAYEEARLMRDQILT
>CYP5269A1 Fusarium verticillioides
37% to CYP53A15 Cochliobolus lunatus, not
found in F. oxysporum
FVEG_00023
MSIVESAYGPFSGRGLICGIMVL (0)
VLIQIVRY
FLSPIHRLPGPATAKLSTFWLASQCQKVRRSEEVLKLHRKHGDF
VRIAPNHVSINTPDAIQQIYGHKTGFVKGPFYDAFHQVTPVVFNT
RNVSEHTRKRRYINPAFSARALSGFEPHMDTEIAAWKRQLLKISNGASPR
VDFSVWTNYLAFDVIASFAFGEHFGFIEKGEDEYGLIKIIDTRGEFMNAL
GSLSPFLRFVMRYNPFDSFWKDGFRASAGFAKIGKEAFEKRKSSDDNSRKD
LLSFLFNAKDPDSKQPIPEEEIIAESISFIVGGSDTTSSTMTNFIDFVA
RDEDLQLRIQQEIDIIFPGEPSDDWVPSEKKLNDLSLLLATLREVMRLRPTSATGLERVTPQGGKTIAGQFIPAE
(0)
TLVSVPTLGVMMDPRIFESPETFRPERWLEPGADELMEYFYPFSTGPRSCIGRN
(2)
FAWMEILKAVAVVFKLFHVKRINPKPTVIREG
FFNKAVECEVEIHKRSFNEACEM*
>CYP5269A2 Aspergillus terreus NIH2624
XM_001213125.1
60% to CYP5269A1 Fusarium verticillioides
ATEG_03947.1 revised
MAIILPEGPMALFREGYGNRIVYVLISVPLI (0)
TLLYIIFCVFLSSLSQFPGPFWAKISPFWLMKQSRATQRTDAV
MRLHERYGNFVRIAPKHISVNVSGAIGEIYGHKAGFLKADFYDA
FVQVKPGVFNTRQADVHQRKRKYMNPAFSARALRDFEPYMDQELRAWKSQFLNMTRRA
NAMVDFSIWTNYLAFDVIGSFSFGQSFGFSQKGYDAYGLIQTIDERGEVLNALGSTPS
WVRPLMKYHPFDSFWKRGVNAKANLENFGRRAYLERKHSKFCDRQDLLSYLLAAKDPD
TGNPLPEEEIIAESISFIVGGSDTTSSTMTNFIDYVSRDKMLLGRIHAELDAAYPGPL
GPDWVADNDTAGTLSLLNATLREVMRLRPTSATGLERVTPKGGRTIGGSFIPEGTIVS
VPTQGLMQDPNIFPDPLSLRPERWLEGNTEALLNSFLPFSTGPRACIGRNFAWMEAVK
GLATLLRLFDLHRTTETETKVREGFFKKATECSVELCRR*
>CYP5270A1P Fusarium oxysporum
Supercontig 8: 131065-131663 (-) strand
No gene model, 85% to CYP5270A1 Fusarium verticillioides
AVIRETLRVYPPAPAPMP*VVPKSGFEFEGVSYPPD (0)
TVISAQPYTIHRSEGVFEGPNELRPECWLNLPSERKDRMYRAFVPFSTNQRG
(2)
CIGRGLAWMHMMKCIARTLQEFDRFELAAGMTDYGMDLIERG
ALAKPRSTEMWVDAYAKAI*
>CYP5270A1 Fusarium verticillioides
only 32% to CYP684B1 Nectria haematococca
FVEG_04347
MNYSTISSLDLHAYTHHLYKWLRVFATL
ALAIVLFKLIEFLCRVTYRLYLSPLCKFPGPRLAASSKAWEIYHSLT
(1)
NDRFRAIHEMHEKYGNVVRIGPNQVSVASPEAFHHVFVTRCSSFLKTDFYATIQPGIGPN
YAGLFNYINHKQAMAERRDLQPLFSPGSLKHYEARFDEQLDILMEVAKQREK
(0)
FFMLDVIGDLALNKSFGQVTSGKEHQYVIDFNNAFMVIGL (0)
QNTFAPIIPLIPYLPFKKLKNAYYGLQRVFSYSQ
ERVEDYLKQDMSKKQGSLMSGYLDPATGEPKDGYSAWSIALAGHGFI
(2)
VAGSEATSITLTYIIWMLIKRPDVDQRLRQELSRLSKNYSNTDLANL
PYLDAVIRETLRIYPPAPAPMPRVVPKSGFEFEGVSYPPG (0)
TVISAQPYTIHRHEGVFEDPDEFRPERWLDVPSEKKDRMYRAFIPFSAGQRG
(2)
CIGRGLAWMHIMKCIARILQEFHRVELAEGMTDYDMDLIERGALAKPRSTKMWVNAYAKAI*
>CYP5271A1 Fusarium verticillioides
only 30% to CYP511A1 Botrytis cinerea,
FVEG_05538 not found in the F. oxysporum
genome
MSLLGRIHDLSPETTKDRLILFFLVYVTCYLTYWTGVVIYRITFHPLAKYPG
PFLCRTSWLYQTYYEAFLSGRMLERLPALHQKYGPVVRINPGEVHIKD
ASVFHQIYKQNTRFTKDPIAYTLGVPNAISMLFDISEHKKRRETLNPSFS
KRRILLLEDLMYEELEKVMSHAMPYIERKEPLPIQDAYYCFTADVISHFT
FGKSIDLISQPNFSRERVEQLRSFTNSIWILIHFGFIHKIVSALPRRVAA
FANEGYQMIVWFCEGLAQDAVRRHEHSDGKPKELGEETIFDRLLAGNNSK
ENEADMSRRKQAPKMAAQQIADESVGLLMAGTETTATMLAYGTYYFMTFP
EVQAKIMAELATVQRTESGRLPIQQIESLPYFTGFVKETLRFAHGVPGRL
TRVVPSGGLYIPSINDYIPEGYVVGMSHMMIHNDPEIFEAPNEFRPERWM
GEEGKQLDHWLLTFSKGSRNCLGMNLAYTEMHLMLANVFTRFDLSLIPGT
HEDMIWLDRAIVRNRGNLRVMAKLKSVK*
>CYP5271A2 Fusarium verticillioides
54% to CYP5271A1 Fusarium verticillioides
FVEG_05542 not found in the F. oxysporum
genome
MAILNTITDVLGPLPETFQGRLVALVVAYTGFSLLYMLFLVIYRLTFHPLAPFP
GPFLCRISWLYQMYFEAIRGGKMLERLPGLHEKYGPIVRINPNEVH
IKDPQVFHEIYGQKTKFTKDPFAYSFGVPTAINVLLDPIVHRQRREMLNPS
FSKRRINMLEDLMYEELGRVFEKITEFVNQGRVIPIQEAYYCYAGDIIS
RVIFGKCLNLIEMPDFATEKIEEIRGFTKGVWISIHFGAIRNLMMNMPQW
LVRMMNESWVGIIDFTEAEASQAITDYHMEGREPKSAKDETIFDRLLDAN
QKSEKERGIKSKFGLKELTDEGVSLLIAGLETTATTITYATYYFHKYPHV
QSRIMAELNSIKLDENGRMPIQQIEAQPYFVGFIKETLRFSHGIPGRLTR
VVPRGGLTVPSAGKTIPAGSVVGMSHLMIHMDPDLFDSPQEFKPERWLED
GGLDHWLVSFSKGTRDCIGKNLAFTEMHLILANIFTTYDIELCPGSDEAM
VMTDRAIARPTSNLRVTAKLKARTV
>CYP5272A1 Aspergillus clavatus
32% to CYP526G1 Fusarium verticilloides
ACLA_061300
MDLLSWNNLPSIAIVLAFVLYYVFKRAYPSPYPGIPYNAASARKFWGDSSGLLDAVKITQDPAKFIFQQTRKLNSPVIQL
FLAPFSNPTIIVDDVREVKDILSNRTHEFDRAPRTQDAYRSLLPHCSLVKATGPAFKHQRRFWEGVTGTPFLRRVAEPKM
YRCALGLIDLLRAQAKMAGGLPFYCFDDFDVAAFELIWELVFGTNVDAIKNARSKALCATSDTVQPPSLDSPARIPVIQK
PDMCEAVSFFINTVAKSLKSVFPTWHLWYLRQQPVYKRKLAFKNSTIDGLIESTRSKLAGLSEGQLMELEESSVLVTGVR
RQLLAHIRQGQPVNVPFPASVQAEIHDELFMILVAGHETKAVLLSWSVKFLIANPEKQEKLRKALVDALPKGFNGEQPSV
KAILSTPIPYLEAYMEESMRAANTSPRLVRRTTTDTQVLGYSIPKGVTVILNPYIGTQPLDIPEHLRSETSRNSKGNFAS
YWDVNGMDDFQPERWLAEDGSFNPRQFPHLGFSAGPRMCYGRNLALMEFRVNLVLLVLNFKFESLPKDLDSMESQQRLFR
MPRQCYVRLSPL*
>CYP5272A2 Microsporum canis CBS 113480
84% to CYP5272A1
ABVF01000250.1
24684
MDILSLNYQLSIGIGLLAFILYFGFKRAYPRPYPGIPYNVASARKIWGDSTGLLEDIKIT 24863
24864
QDPAKYIFHQSRNLGSPVIQMFLAPFSNPTIVIDDVREVKDILSNRTLEFDRARRTQDAY 25043
25044
RSLLPHCSLVKLTGPAFKNQRRFWEGVTGTPFLRRVAEPKMYRCALGLIDLLRAQAKMAG 25223
25224
GRPFYCFDGFDVAAFELIWELVFGTKVDGIKGALSKVLSVTSDTVQPPSIDSAAQIPVIQ 25403
25404
KPDMCEAVSFFISTVAKSLQSVVSQKWSLWYLRQQPVYKRKLAFKESTIDGLIEATRAKL 25583
25584
AGLSADQLMEVEETSAVVTGVRRQLLAQMRQGQPINVPFPALIQAEIHDELFMILVA () 25754
25823
GHETKAVLLSWAVKFLIANPGKQEKLRKALVDALPKGSNGEQPSSKAIMSTSIPYLEAYM 26002
26003
EESMRAANTSPRLVRRTTTDTQVLGYPIPKGVTVLLNPYVGTKPLDIPEHMRSETCRGSK 26182
26183
DNFESYWDINGMDEFHPERWLSEDGSFNLRKFPRLGFSAGPRMCY () 26320
26415
GRNLALMEFRLNLVLLVLNFKFEPLPKGLDSMESQQRLFRMPRQCYVRLSPL* 26573
>CYP5273A1 Aspergillus clavatus
34% to CYP531D2
ACLA_055650
MLGVLLLFFATAGLAWFLATPFRTGLWHIPGPWWRRYTDFFQALDAYNGRTCQIIQRLHKEYGPVVQVGPRTVIFSNPSM
IEKVYATRAPFPKSYHWRPLRTELKGVHYPSLIGTEDTKTHAALKRPISGIYSMSNVTKSESFINECILQFVKEVDREFR
GKEKPLPVFTWMHFFAYDTIMKLTVSADFGLIRGEADRKGMFRGVDAAQTYRAMAACMPWVHSLLKGSPITKVFEKRMGS
FPRRARELIQSRRANGAARTKDREDLLSQILDTQKKHPNVVDELVVHGYATTPLLAGADTVTIGLTSVVYFVAKHPEVAA
KLHAELKSSGLQMPPPWVLIHKMPYLDAVIRESFRCHPIGAMLSRRAVPPGPGLMLADGHTLPPGTAVAVSGWSTHFDPD
AYGDDVHDFKPERWLKRPSESDEEYAERLHRMSKADLTWGAGDRACMGKNIAKCELYKLIATLYSIFDIQLVEPTKEWKI
KETVLAKQEGVEARITFRPGASLDQLVQGDA*
>CYP5274A1P Aspergillus clavatus
pseudogene
25% to CYP639A3 Fusarium oxysporum
ACLA_055770
(+) strand
GHIRNILQFSRVLTNRPMMMFAMRKWFYTPLESMHPYAAGSKKEHLQDLQAGISI*FPSGQ
SLLAMS*RYLAILKRCRARVEIPEKGELVIEDFFTWLQSQVTPLVIKAMMGSC
ILEMYPKPVEDFWEFNFNI ()
XXXXXXXXX
WLIPSAYRTRDQLLANIKAWNQFAHPHSDCSKSGAGDPEWDEFFRTKFRKAREETLKQH
RLDNNAIASENLGLLF
XXXXXXxxx
VFWYVFEALKDQNLQGRLQTKLQACYSLRSSTFDLTQFSTKPLLQSTYIKVLR
LRAATTMTCTKEDSDFQLRPDYVVPQDMTTTIFSSITAQNQEAWLLVQPQSAERPLD
EFWLERLLVH ()
xxxxxxxxxxxxxxxxxxxxxxxxxx
RKRPSTWRG*PSAGWPTVAGQRMRPGCHFAKNEIIGTLGLLLEMFSCELVDQRQAEQVKP
DERWFPYGTSPPTRKVAVRLRRR*
>CYP5275A1P Aspergillus clavatus
50% to CYP5100A2 A. niger
no gene model but adjacent to CYP5274A1P on
opposite strand
only 33% to CYP5274A1P Aspergillus clavatus
(-) strand
RLCPGRHFAKRKMILTADIMVTLFDGEILADVRTLRMDMRGFGFGTLGVDGPVPVRIRRRKINE*
>CYP5276A1 Aspergillus clavatus
31% to CYP503B1 Aspergillus nidulans
possible gc boundary at KVWPF, N-term region
not well supported
ACLA_095960
MFPTSLVFGATIVFLLYIAKRLYDAQERYPSHIPIIEPVPGTKNEDVIKAQYAKVWPF
(1)
SSAVDVFERLCGRYTFLGSAHPDRP (1)
GWNLLGDQMYAAIKYVQGPLTKNINRMLDKIYGEIDRVLQREV
GNGAGRVVNVDFLTTEVYLHVFEMVLVGDDLGHDEEWLRIFADYPRVAFNAAVRLAKYHWLVRPVVARLIPEMRGLLDYR
QEVYDILRPFHQERLQAMQTPDFKEPDDYIQSFINHAGAERGNTWRLAESISGTSMAGIQTTARVLYQTLFDLVQYPEYL
GPIREEINHAISQEGGSANLSQAGLLSLVKLDSFIKESQKFHYNNLVSSNRKLFRSLTLSDGTVIPKNAYVSIPGLAHAV
IDKTGNTRPFDGFQWAEKKLTAENPSVYNYVFSGQDDLEFGAGLHACPGRWFASIALKSALVRILLRYDFRLPEGQKRPV
DEYNDGLEMEHDVTATLEFLAREHC*
>CYP5277A1 Aspergillus clavatus
35% to CYP5068B1
ACLA_063150
MLFAVLLCLLAALLTFIVSCRSSQSREKPLPPGPSKLPVIGNVHQVPRLQFWKTMADFVDRYGPIVSVKLGQQQLIVLGN
QTIARSLLDRKNTKYNSRPHLRVAERAWLGPMVALMPYGPEWRTYHLMQTAVLSSRAVRLYDKIYSTETTQLLHDLLSTN
DYPPRIYRYSSGLAYAVAYGMRMPRGDEFEISEINEIALKFFLAAQPGYWSVDDFPFLRYLPGFLTPWKSYAAHVNQIIS
DGFQRAYSNALQRDSWSWARVLAEQETLRALPKGSISFVVGELWAAAHFSSSNMLVALIRLILYHPEEVQRAQEELDSTV
GVQRLPQLADLDNMPYVRAFIREALRWLPSSGTPHASTEDDEFMGYRIPRGSMVVPHYWFVDMDSDVYMNPLKFRPERFV
NDPKLPLRTFGFGSRICTGQYFAQNSFSMVIMRLLWAYNIRFPDYVDTEAEPIGQLEARIFTMNEKPTEAVFTPRSGAHR
ELIEQAYASLDSVDDALKPLQSIKVNIPKSF*
>CYP5278A1 Neosartorya fischeri, Aspergillus
fischeri
33% to CYP636A1, 76% to CYP5278A2
NFIA_098920, AAKE03000027.1
Note: this seq does not have an ortholog in A.
fumigatus
MGLISLLVLSIVIYCVLRLLEVKRCKNVATEAPTIYGWIPIFGHALGLLQYGVSYYRMLR
(2)
ETTNMPIFTLFLGFQKVYVVNSPALISQINHHQKVIDSNPPFLIIVMGKLFDFHKDDLAELMRNPNETGS
LRRETRTVEHSLLERGAAPLHEIFTAMIQEVALRLNSLASKGPATIKLKCWLRETITTCTAQATFGPHNPFAQNQSLLND
FWHFESGIKGLTMGIFPTLTASGPARARHRLVQAFHRFVQGSFIKREETCELVRQIGEVAHRHNRGTDYLARYYFGVFSA
FLLNTVPVTFWTISHIIKNPDLLARIRTELEDVVQEFVDADGIRTRVLHISTIRERCPLLLSTFHEILRYVGASTSTLVV
HEDVWLDDTYLLTKGSLVQIPATAIHSDPNIWGPDAANFDPERLHAAPNKVHPSANRTFGGGNTLCPGRHLASDEVLEIT
AMFLSTFDMGFEAKPSWPRRDETNMLSVIKPRDDLSLNLTRYPHMEKVLWGFETS*
>CYP5278A2 Penicillium chrysogenum Wisconsin
54-1255
76% to CYP5278A1
AM920436
MNLIPLLVLSIILYGVLRLLEVRKCKITTSEPPIVYSRIPIVGHALGLFRYGVSYYRML
REQTNLPILTVFLGLQKVYVVTSPALISQINRRQKVIDSNPPFLTVVMGKLFSFH
KNDLAELLRNPNETGSLRRDTRTAEHSLLERGAAPLLEIFTGMMQEMVIQLNTLASN
GPVTIRLEGWLRETITMCTAKAVFGPNNPFAQDPSLMQDFWVFESGLKGLTMGIFPE
LTASGPARARRRLVQAFHRFVQGEFIARGETCELLRQVEDIAHQHNRGSDYLARYYL
GIFSAFLLNTVPVTFWTISHILQRADLLARIRTELDDVARESVSTNGIRKRYLDVAS
IRERCPLFLSTFQEILRYVGASTSTLLVHDDVWLDGTYLLTKGSLVQIPATAIHSDP
KIWGPDATTFDPERFLKAAPNQVHPSASRTFGGGGTLCPGRHLASDEVLEVTALFLS
TFKVGFEAESGRPRRDETGMLSAIKPKDDLLLRLTRYPAMGNVVWGA
>CYP5279A1P Neosartorya fischeri, Aspergillus
fischeri
C-term pseudogene fragment, the sequence immediately
upstream has strong similarity to
C-3 hydroxysteroid dehydrogenase. This
suggests a sterol biosynthetic gene cluster that has degraded.
NFIA_098930
Note: this seq has no ortholog in A. fumigatus
VRLSNQAMSTRHVMENTFITDSDGREYLLRAGSIVVMPATAHMEGDVWGINKIDFDPERFLDWEDHKASRDRRLIYMPFGGGRHLCP
GRNLAKAEILGFIVMLILSFDMEDGANLEQPIRVPTLEPARLGQGVGKPVYLRTGDKFPVRLRTRKGLESVNWRFLA*
>CYP5280A1P Neosartorya fischeri
most like CYP630 (33-39%), 37% to CYP630D4 Neosartorya
fischeri
NFIA_099450, one stop codon, possible
pseudogene
Note: this seq has no ortholog in A. fumigatus
MLLVLLFFISMAPALFWLFIV*LRDEKGLRK
YPKQNWASGLTALAYGWECGRPRRDIH
SKRLHAALQKYPIVRIAPNWLAFGRSQAARDIYGYNSKCVKAATYDLLSQGGANLNNISDKRFHSSRR
RMVAPKNIQEWEPKVAVSVADLMNQIDARCAEDQGVVVEPSSFDAVHWIFLFSVETVIKIMLSKDVFFLRNGTDHVYFQD
ENGLPQAVQSIHNSHASQRAAATVIWDIQRFALWIRLTKMVSKRYADNWAAGPKFHAAMEALTKERIEQYSNGERFSDLF
QPMLEDKHGEASEITLKDRIAEVEQAVGAGTDGPAVSISMTLYYLIRNPHTFAALRKELDTVLSTEDSVAPWGKVKSLPF
LRACIDEAMRLAPPVATELIRRTPPDRHVIIDGHLIPPDTNVSIAAYTSHRDPQVFPDPETYNPDRWMAKGSDNLRNMLG
MFIPFSAGTRGCIGRNVSILMQSVCVATLVYHYDFALPHENWEMEFEEWFSLWPLRLPLGVRRREPASFPQA*
>CYP5281A1 Neosartorya fischeri
39% to CYP68L3, 38% to CYP5067A2, 93% to CYP5281A1
Aspergillus fumigatus = ortholog
NFIA_100500
MIRFEDASIGTVWVTCLLAVGLYFIRSRLLGDQFDGFPSVNSRKPWEVLNVFAHRRFQKNGPEYLKAGFSKSPIFGVVTD
LGPKLVVSGAFIKDFKDERLLDHYRAMIEDFMAEVPGFESMFLGNLHNTVLRDVISVITRELEQFTLPLSDEVSAALGDT
WSVSPDWHEVTLLPSMLGLIARVSSLIFVGEPLCRNPAWLETVVNFTIVRHHAILALHMCPAVLRPVLHWFLPPCQKLRR
EIKAARGLINSALEESRKNPRTDRFSSLTWVDAFASGNKYDAAMVQLRLANASIHSSADLLIKVLINLCDQPGLIQDLRE
EVISVLEKTGWRASTLNQLKLLDSVLKESQRLHPITTGTFSRFTRQNIKLTNGTEIPTGTPVMVTNDVAGDADIYPDPEV
FDGYRYLRLREGADKSRAPFTTTGQNHLGFGYGKYACPGRFFAATEIKIALCHMLLKYEWRLVKDSPHDMLTSGFASFRD
PRARIEVRRRAPAPKEFEVLTQK*
>CYP5281A1 Aspergillus fumigatus Af293
AAHF01000006.1
93% to CYP5281A1 = ortholog, 40% to CYP5067A2
Part of a toxin biosynthesis cluster with
another P450 CYP5074A1 and a PKS
2243087
MIRVEDASIGTVWVTCLLAVGLYFIRSRLLSDQFAGFPSVNSRKPWEVLNVFAHRRFQQN 2243266
2243267
GPEYLKAGFAK () 2243299
2243359
SPVFGVVTDLGPKLVVSGAFIEDFKDEKLLDHYRAMVEDFMAEVPGFESMFLGNLHNT 2243532
2243533
VLRDVISVITREL ()
DQFTLPLSDEVSTALGDTWSDSP ()
DWTEVTLLPSMLGLIARVSSLIFVGEPLCRDPAW
2243892
2243893
LETVVNFTIVRHQAILALHMCPAVLRPVLHWFLPPCQKLRREIKTARSLINSALEELRKN 2244072
2244073
PPTDRFSSLAWVDAFASGKKYDATMVQLRLANASIHSSADLLAKVLINLCEQPGLIQDLR 2244252
2244253
DEVISVLEENGWRASTLNQLKLLDSVLKESQRLHPITT 2244366 ()
2244426
GTFSRFTRQNIKLTNGTEIPTGTPVMVTNDVAGDAAIYPDPEVFDGYRYLRMREGA 2244593
2244594
DKARAPFTTTGQNHLGFGYGKYACPGRFFAATEIKIALCHMLLKYEWRLVKDSPHDMLTS 2244773
2244774
GFASFRDPRARIEVRRRAPDPQEVVLTIK*
2244863
>CYP5282A1 Neosartorya fischeri
49% to CYP5282B1 Talaromyces stipitatus
30% to CYP609A1 Magnaporthe grisea
note: this seq. has no ortholog in Aspergillus fumigatus
NFIA_101520
MDFQIISRFTDGADFQWAKFGTAAFLAVVLSALAFLSYTPRVHQKSPAFTSHKLPFIGSLGFTTEQW
(2)
NWWKSATAES
KTGNFSFWLGKRHVVGVTGEAARKMFFTHEALDFVSGALIRPINIHFWPPIHDIFRPDVKSSRKNTYFLRRLYELQSTEQ
LNHYLPQLLKDARVGMAGLSRVTKPSVSCWETVFTQDVRLLCTDEIIADPKLLATFGRHVETLLFTFSHYNVCFPWLPSP
SYYKRRYARYALYNLMKDIVNKRLKNGARRPNDPVQILLDYNDKLDHIIEFFITVLFIAPANSRIIGGQMLNIMSIHRDW
QEKVYADIKAAAAAHSPDKNAPLVDQLASIPLHAWENSFPSIDLCLQETIRMWTSFSMARLNVSPNPIPIPGSDEVIPAN
TFVCYNSTEVNFSDTLYPDPKKFDPVRFLDGREEFRNEAYGFLGWGRGRHPCPGMRWAKLQQNIIIAYAVAMYDWSSCDE
TGKPTPQAVHVKELNAARGTVLPSAYCKLVPREKV*
>CYP5282B1 Talaromyces stipitatus ATCC 10500
ABAS01000032.1
49% to CYP5281A1
196721
MDFNAQNFQSPVTISLAGLLATLISLLAYMSYSPPIDKRSPAFTSDTVPFIGSWRFFTQKL (2) 196873
196929
PFWRNSMALSKTGNFSFWLGKNHVVGVSGEASRKMYLESRSLHLIKGITLIGHGPDFIDGR 197111
197112
STVIHNIWKSAYTNDRTYATRRLLDLQKSEHLVKRLPRVTRDARLAFEEMPNNATGVM 197285
197286
NPTKVCYRLVVMQGSRLICSNEIADDPQQLNRLVRYVSTLQSTSSLHLLAFPWLSYFSVS 197465
197466
YWKRRWGRNGITQIVKPIVNRRMRKGAPRFDDSLQFLIESGDSKDYITNFLISMLFIVAA 197645
197646
NAGVLSGAMLNIVAHHPKWQEKIYDEIKAAAAIHSKNSNAPLVDQLDSIPLGAWETSFPS 197825
197826
IDLCYKEAIRMWVAFPMGRFNDTHSPIPIPGTNEVIPPGSFACYNTLDVHYNEKLYPDPM 198005
198006
KWDPERFLERREEYKKEAYG (1) 198065
198151
YMGWGAGRHPCTGMRWAKLQQNIILAYALALYKWSGCDEHGDPNPHFAQPTTALNELAPRL 198333
198334
PQGLWCKYVPRENV* 198378
>CYP5282B2 Mycosphaerella fijiensis
56% to CYP5282B1
Talaromyces stipitatus
estExt_fgenesh1_pg.C_70410
MSFLAANATASVLSSLPTNVAGIDLNPMDLQSPWGAYLPVLMALGFLVYLSYTPRIKGNIPAFTPETYPIIGSYKFFTHK
LSFWKAAQRASKNGMFSFWLGKNHVVGVSGEAARKMYLENPAMDHIKGVILIGHGPDYIDGRKTKQHGIWLPVMAGNKSY
AQKNVLNCQKTAELTKRLPKVTNDVRKAFESVASQGFIINPARMCAVLTWDTATRVFAADELIDVPENRAKLLYYLPILQ
KTSSCHLLSFPWASYFSLPYWKRKYGREGMRRLVTPIVEARMRIIDPVRADDPLQTFVDNGDSADYMINFLISMIFISAA
NGCVVSGAMLYSIAHHPELQEKIYQEIKAAANQYAADSSAPLVDQLDSLPVKAWENMSETIDLCYKECIRMWVAFPMGRM
NEGTTDIKIPGTDEVVPAGGLCCYNTIDVHYSEKLYPEPLKWDPARFGEGRKEMEQEAHGFMGWGAGRHPCNGIRWAKIQ
QNMMLAYAFAMYKWTGCHKDGSPNTDFIPPTTALNELAPSLPQNLFLKAEPRK*
>CYP5282C1 Penicillium marneffei ATCC 18224
ABAR01000002.1
49% to CYP5282B1, 44% to CYP5282A1
MTMNVTLPTRM
1300609
VSLDPEFYQSPVTIGLGTILAAILSLFAFVSYTPRVDKRVPKFTSDTYPFIGAANFMWRKG (2)
1300427
1300366
QFLKDSFKESKTGHFSFWVGKKHVVGVSGEAGRKAFLEGP 1300250
1300249
GLDFVQGSGLRGVGLRKLTPIPEIFKPNFHNGRSYFLRRLIDMQKSEVLRNHLARL 1300082
1300081
TSDTRKIFQSALAKDTTGVTNPAITCARIVYTHDMLLFCCQEIADDTKIFEELFEMYNTM 1299902
1299901
QAASSFKAVFFPWIPSTDTRKRAERLKYLQDLFDPVVDRRMRGITPRQEDGLQFMIDS 1299728
1299727
GDKKANIADFFVSIIFIAPTNSRILMGQMLHNMASHQEWQEKVHAEIKAAAKAHAKNPNA 1299548
1299547
PLVEQLDSLPLDVWETSFPTLDICFKEAIRMWVVFSMMRKNIGSTPIELPGSNEVIPAGS 1299368
1299367
YAIYNTAEIHLNPELYPEPTKYKPERWLPGNDYYKKVTYG (1) 1299248
1299183
FLGWGDGRHPCPGKRWAKLQSTITVAYALAGWKWMSIDD 1299067
GIANKSSSDGGHGTVLSGKLLKFVSRDE*
>CYP5283A1P Aspergillus fumigatus
Supercontig 3: 828806-829117 (+)
~68% to CYP5283A1 Neosartorya fischeri at the N-term
probable ortholog to CYP5283A1 Neosartorya fischeri in rapid decay
MLSVYV &THCGICCHSIPIY &
YLCLMRIQSSRKQQPYTW
EYSAALSLCRFLIVAL
RSGYETW*CRSNLP*VNKPEF*DILGLNTTARISRHSLEALAK
(0)
NLGWVYSLGGRYIPLFKHEIRL &
QESQLTISEYEPHNQLTANHHILQHYTHNKMSLQLGKHCFGGSL
E*SRFLIPETAGAILGSGRISFLRPRHCCGP*FWRDLTAVFDLLQLWP*YVW
PIVRWFLLTCRAARAESANSRARLTFRKAKERK
DLVEPLREEICSVIQEHA*TKAGITKLRFIESVMKERNRLSPLGQMYQRRRILEEV
>CYP5283A1 Neosartorya fischeri
35% to CYP5074A1
NFIA_004940 revised
MLSVYVTLCGLCCHFIPIHGYLRLMRIQSSGKQQPYTWPLKYSAALSLCGFL
IVAIKSGYEAWRCRPNLPQVNKPELWDILGLQAKRKYLSPDTSSFIEALAK
(0)
ATRVYTNLGWVYLLGGRYIPLLKNETRLGQEFQSTIPGYEPYYQ
LTADHHILQHYTRSKMSLQLGKPSFGGKL
VKPVSRNTARTLHKMLGDSQEWSRILIRETAGATLSEAAGSLFYGPDIAAD
PEFGESVLRYLTFSIAGMPKLHLWPQCLRPIVHWLLPTCRAARAELAKSRARLTLLLVKQKKERQKADDLDQIDVFSFIE
TLPPDQRGDPACLAIALTIAATHTTATLLTTIIYQICKHPDLIEPLRAEIRSVIQEHGWTKAGITKLRLMNSVMKETNRL
SPLSQAIMRRVATADVPLNRDLTIPKGAITMTSTLDTMWDPQIYPDPQKFDGYRYLNLAKQDPYWNRTSSFVATSPESLG
FGLGKEACPGRFIADLEIKLILCYLLTHYDIKLPGGITAKPRYEGVFLLLDPGDILIRRRPEEEAKFPDWSHDDQV*
>CYP5284A1P Aspergillus oryzae
Supercontig 20: 496256-497391 (-)
97% to CYP5284A1 Aspergillus flavus
MSLGLEIPNITFLIAIA
RPLSRTPPIVSFTVRVLIRPLL (0)
(missing 5 and a half exons)
GPLIWTQISAILQKSNEKPSKNDVRAYFHHSFLLPRVWKLTPQYQGIPASDP
()
VVVFIFASVHQT ()
VSITMWTMFQLALHPENQDITRREIHDLTRR
DFVPIPMSELNMRTLRKASCTDSFIREVFRMKGDAVNLVRMARKGVQLGDYIVPK
(1)
GSLVLPLVSLFHWSPRYNEGDPKKLDGMRWVEKQKAASTTDPGHLSFGLSIWTCPGRFMAVA ()
EIKLAVFALLADTRLELVGGRHDVADNFNVTGNPPEGELVLKRISVC*
>CYP5284A1 Aspergillus flavus
31% to CYP5157A1, similar to N-term of
CYP608A2
AFL2G_09003
MSLGLEILNITFFKAIA (0)
RPLSGTPPIVSLTVCVLLRPLP (0)
TNNLPEALERQIQQHGPVMGLRRDGR (0)
VEYIVSDELTFQVLTDDATFSFELGTAK (0)
ILRIEFLPSMFGNSIFQDIDSVVDKLLTKRLDTMIHRGR (0)
PIFERNSAELLKYCPEGPVNLLPRLQRTVAEAAMSIVFGDA (1)
SELIGTFRSRSILARYFPALWQIVTWYVYETSLW (2)
LKVVICTVIIRFGIAFGPLIWTQISAILQKSNEKPSKNDVRVYFHHSFLLPRV
WNLTPQYQGIPASDP (1)
VVVFIFASVHQT (2)
VSITMWTMFQLALHPENQDITRREIHDLTRRDFVPIPMSELNMRTLRKA
SCTDSFIREVLRMKGDTVNLVRMARKDLQLGDYIVPK (1)
GSLVLPLVSLFHWSPRYNEGDPKKLDGMRWVEKQKAASTTDSGHLSFGLSIWTCPGRFMAVA
(1)
EIKLAVFALLADTRLELVGGRHDVADNFNVTGNPPEGELVLKRISVC*
>CYP5285A1 Aspergillus oryzae
GenEMBL BAE56589.1
98% to CYP-un2
Aspergillus flavus
begins
supercontig_5 61728-63540 (-) strand
213 bp from CYP65AB1 head to head
arrangement
formerly CYP-un2
MVNEVGTVYWPYVAALAVILMVAHRARRQHTIPAVGDANDSNLLEALKEGSQR
(0)
YPESCFQIATKDIPTVIVPLKCLSTIAYAPEEKLSLGREVYERLMGRYTRMVKSDHLAEFVRAGLMKNAGNSVA
LLQEEAERTVSSQIGHCP (1)
DWKSVALFPTMVKLVSLHISRSFIQSPLSRNQEW (0)
IDLTLDYAISTVTVAGKMSNTHWALRPFKGHFLPETADMSRQFTRARELLRPTLEARLQQ
RDKVPNDLMQWIINNYPDQEDDLTLHTRLQLEAVQAATYNLAFQ
(0)
LVHFFYDLLAHPEYLQPLRDEILSVSESCNGHWTPAALSNLRKCDSFLKESQRLNPIGI
(1)
VSVSRFALSPFRLPGGSTVPAGVSVSAPSMMVNL
DDSLWTDPTSFDGYRFEKLRTIKGNELKFQYASTSTSELNWGYGTHACPGRH
YASNQIKLMIVSLLSRYEFQFDHEQT
DKKAIVERPPNVVDGVRIMPNPQTLVMVRSLGNVNEGCE*
>CYP5285A1 Aspergillus flavus NRRL3357
GenEMBL
AAIH01000268.1, AFL2G_07275
98% to CYP-un2
Aspergillus oryzae
Supercontig 8:
71207-73019 (-) strand,
216 bp from
CYP65AB1 head to head arrangement
formerly CYP-un2,
suspected gc boundary at SSFQ
MVNEVGTVYWPYVAALAVILMVAHRARRQHTIPAVGDANDSNLLEALKEGSQR (0)
YPESCFQIATKDIPTVIVPLKCLSTIAYAPEEKLSLGREVYERLMGRYTKMVKS
DHLAEFVRAGLMKNAGNSVALLQEEAERTVSSQIGHCP
(1)
DWKSVALFPTMVKLVSLHISRSFIQSPLSRNQEW
(0)
IDLTLDYAISTVTVAGKMSNTHWALRPFKGHFLPETAEMSRQFTRARELLRPTLEARLQQ
RDEVPNDLMQWIINNYPDQEDDLTLHTRLQLEAVQAATYNLAFQ (0)
LVHFFYDLLAHPEYLQPLRDEILSVSESCNGHWTPAALSNLRKCDSFLKESQRLNPIGI (1)
VSVSRFALSPFRLPGGSTVPAGVSVSAPSMMVNL
3887
DDSLWTDPTSFDGYRFEKLRTIKGNEQKFQYASTS (2) 3988
4047
ASELNWGYGTHACPGRHYASNQIKLMIVSLLSRYEFQFDHEQTDKKAIVERPPNVVDGV 4223
4224
RIMPNPQTLVMVRSLGNVNEGCE*
4295, 71207
>CYP5285A2 Aspergillus clavatus NRRL 1
GenEMBL
AAKD02000041.1
pseudogene, 70% to
CYP5285A1, 33% to 654A1, 28% to 503A1
ACLA_066890
Supercontig 80:
639186-639335 -
formerly CYP-un3
MEAFWEHIKTLYWPYMATLAAIVLAVRLLCRRQHPIPIVGSPNEPNFMAALKEGAQR (0)
YPNSCFQIPTRDIPTVIVPLKDLSTIAYAPEHTLSLGREVYERLMGR
YTRMPKSHHLAEFVRAGLTKNAVKSVALLQADAEWTVSSQLGQIPRISVSHN (1)
DWKSFSLFPTLVKLVSLHISRSFISPPLSRDQAW
IDLTLGYTISTVTVAAKMSNTHWSLRPLRGLILPERREMSRQFQRATALVKPILASRLEEEEVEH
GDLMQWIIDHYPDQKDDVVLHTQLQLEAVQAATYNLAFQ
()
LIHFFYDLLVHPEYIEPLREEIQTVSECCGGRWTPSALANLRKCDSFLKESQRLNP
PFRLPDGSTVPAGTSVSAPAMLANT
28289
DKMLWDDPLVFDGYRFEKLRAIGDNEQKFQLSSTS (2) 28393
28450
TSELNWGYGTHACPGRHFASNQIKVLMAALLLRYDFRFAKDQNSDTEYK 28596
28597
RPSNVVEGVRIMPNPNVEVLIRNRVEM*
28680
>CYP5286A1 Aspergillus oryzae
EST oryzae EY428112.1 N-term
98% to CYP5286A1 Aspergillus flavus
MASPMKSDFLAGSHMKLPKIGIAAAVAVVASIVIYLALSNFFVGTD
(0)
EFKNDESQSIKEYPDNTRFMRFTHGKQLSKAGEDLAGSEPYLIHNGKLKELVIFAPEHLQEFHRKDANSHYKPENMNMGDYAGQ
()
LLGQCVGQLGGTKWKLARSHMDPEFSYRASRSMMKRFSQEIDSWVSHLSEN
PTRRSTQKDVFVQDVKKRCKDLSLRSIAISIYGETFSEE (0)
NYAILSTMNELHEKIIFVAFLNKRVMSKWYNKLPTAEKRLMDSFQTQWKAFNLAQIKLARE
(0)
KKLSCPAEKIYVGVEAGDMSLPE (0)
FLQSLDEMLFTNIDITGSILALIFQHLAKDQAMQKKLRAEISAHRAQPGYTVGDYISKQNTLLHFSLLESIRVTPAM
(1)
YFTLPECNASPKRIGGFHIPAH
TPTIVDVNRLNKNESIWGTEADAFRPERFFGLDPARYRFGFVRWGIGRDKCLGKN
MAEVILKLAILAVTDKYTLHVPPALPDQGEKSEAGFTINRDVEVEFRPAI*
>CYP5286A1 Aspergillus flavus
40% to CYP685A2, 42% to CYP5237A1
EST CO136609 confirms the C-term
98% to CYP5286A1 Aspergillus oryzae
AFL2G_07510
MASPMKSDFLAGSHMKLPKIGIAAAVAVVASIVIYLALSSFFVGTD (0)
EFKNDENQSIKEYPDNTRFMRFTH ()
GKQLSKAGEDLAGSEPYLVRNGKSKELVIFAPEHLQEFHRKDANSHYKPENMNMGDYAGQ
()
LLGQCVGQLGGTKWKLARSHMDPEFSYRASRSMMKRFSQEIDSWVSHLSEN
PTRRSTQKDVFVQDVKKRCKDLSLRSIAISIYGETFSEE (0)
NYAFLSTMNELHEKIIFVAFLNKRVMSKWYNKLPTAEKRLMDSFQTQWKAFNLAQIKLARE
(0)
KKLSCPAEKIYVGVEAGDMSLPE (0)
FLQSLDEMLFTNIDITGSILALIFQHLAKDQAMQKKLRAEISAHRAQPGYTVGDYISKQNTLLHFSLLESIRVTPAM
(1) YFTLPECNASPKRIGGFHIPAHTPTIVDVNRLNKNESIWGTEADAFRPERFFGLDPARYRFGFVRWGIGRDKCLGKNMAEVILKLAILAVTDKYTLHVPPALPGQGEKSEAGFTINRDVEVEFRPAI*
>CYP5287A1 Aspergillus flavus
33% to 617D8
AFL2G_04005
Note: there is no ortholog of this gene in A.
oryzae
MAFLAAYRLYLYPQFLTPFRSLSTP (0)
GRHWLWGNYLDRNENPIVYLRREAVLFYKEDIVRVYGPLNIEVLFAMSPR
AIRDLLCRRSKDFVKPRVAEKIFSTVGARGLVASNGNKHR
(0)
LHRQQISAAYTPCNVREQCPIIVEQALRMAESMDAENKEQGRVYLWDILNRAGL
AIVCKTQLDTHFDPIRHETTVKKVLERFLFGISLGTCVKALMCCALPESIQTIVQPQVPGLADLKCFVRRIITEEKKQTQ
TRRRMSGKRATLLSCLLEGDIFGDGERVQQSVDFLLAGSATVTFTMQWALFVLSRDPDLQGKVRNEVRQCLPSPTTTRLD
EWSHIFLKRLDDGLPSLQAFCNEVFRCYPAISLTGREACCDTTLAGVYVPKGTLVLLSPPVANQNPEWWGPDAAEFNPAR
WLNGDGSFNSSAGGNQIHNRYTFLTFGQGPRSCIGQELGRLEVNIMVAIMLGKFEMQLADEQKEPVVMGILSPIPRDDVV
VHLRELHGW*
>CYP5288A1 Aspergillus flavus
38% to CYP52G6
Aspergillus niger
AFL2G_06019
Missing N-term (about 8 aa) in a seq
gap
note: there is no ortholog of this gene
in A. oryzae
ALLACIAFFYIFRRLTEGCKL
RKLRQSSSFRNPPRVQSRGPLGIYNVLERLRFRGDILDGYLARQFETYGFTHEIKELGLHAI
ITAQPENIRAILSTDFESFGPGKIRKRS
MAPLLGEGLFTVDGEKWKHARNMLRPLFVKSNITDMALVQRHLERILAHAIPDNDPAWSGWTEPVDLKSLFERFTMDTAT
ESIFGRSVDSQLWAQASFPMDEVDDSAASMTQNFARAFDVSLVGVVVRMITGRLSFLFKRRKFRSAFSFVQQYVSLQVHR
LLKDDLLQREGTKKPFLAVLMEAETLNETQLHEYSTNLLIASRNTTAALLSFTFALLSLHPDILEKLRSAILSTFPVDGH
PARTRDGFSSSTITAEKLLQCEYLQWVLREVLRLFPPIPITGVEAKKHTALPLGGGEDGEAPILIPKDQLVIFFPYFMHR
RRDIW (1)
GDDAESFRPERWAKSPPSWAYVPFSGGPRTCLG (1)
KQYALIHASYVVTRLLQSFSRIRPAHPTNNWLSAETESERSRLKVRSIRKSGFISLSVRNFQVQFWKDESS*
>CYP5289A1 Aspergillus oryzae
Supercontig 13: 1279061-1280977 (-) strand
MDSILSEALSSAVLYAPTVGVIATLSLIASFLIILVSDLIYCGFKTWAVQWAPCIPGKSLLSE
RFRLKKSMDDYYEEFADAYRK (0)
YSKNGRAFSISDNIGEGYIVMLPPQHYQDWYNVPRNHLNWGKAVNQ
(0)
FSLDDLGIDLGWHIAPLTVQKCSQVDFI (1)
KRVEGPIGRELDRLLVENLTESK (1)
EWHLCSLFNTVVNIYSHIA
LLVVLGPEFSNHTALAEQLPLFSMQLSDRMGSEKSYPIFFKPLVRKFSAKTRHVQSIMAE
MKKTIVPEIRRRVEQRRRSTKQSTQNCFLDVMIELLLRKDLLSHDA
VKDDERHFDTVAIQ
TIFLLFEVLGGLTPATTSSLYRIMKAPEYLAPLREELAAALKQTDNAWSFDIFKHTPKLE
SFTKECLRVFTPSGSY (2)
GGLVEKPLQLRSTGRTLSPGTKFSLPAQQAHLDPDNYPNPNVFDGYRF
CDPQSGACDIRGTITPSAKWLIFGIGTSACPARLLATRISQTLFVKVIRNYDLRLKVEDG
QPEVVYSAANMFVNFNTKMYVKSASI*
>CYP5289A1 Aspergillus flavus
34% to CYP5110A1 Aspergillus oryzae
93% to CYP5289A1 Aspergillus oryzae
AFL2G_09861
MDTMFSEALSRAVLHAPTVGVIATLSLIASFLIIFVSDLIHCGFKTWAV
RWAPCIAGKSLLSERFRLKKSMEDYYEEFADAYRK (0)
YSKNGKAFSISDNIGEGYIVMLPPQHYHDWYNVPRDHLNWGKAVNQ
(0)
FSLDDLGIDLGWHIAPLTVQKCSQVDFI (1)
KRVEGPIGRELDRLLVENLTESK (1)
EWHLCSLFNTVVNIYSHIALLVVLGPEFSNHTALAEQLPLFNMQLSDRMGSEKSYPMF
FKPLVRKFSAKTRQVQSIMAEMKKTIVPEIRRRVEQRRRSTKQSTQNCFLDVMIELLL
KKGLLSHDAVKDDERHFDTMAIQTIFLLFEVLGGLTPATTSSLYQIMKTPEYLAPLREE
LAAALKQADNAWSFDIFKHTPKLESFTKECLRVFTPSGSY (2)
GGLVEKPLQLRSTGRTLSPGTKFSLPAQQAHLDPDNYPNPNIFDGYRF
CDPQSGACDIRGTITPSAKWLIFGIGTSACPARLLATRISQTLFFKVL
RKYDLRLKLDNGQPEVVYAATNMFVNFNTQMYVKSASI*
>CYP5290A1 Aspergillus terreus
33% to CYP5055A1 Nectria haematococca
ATEG_08242.1
Note: does not match any other Aspergillus
P450 at the family level
MSAQSILSNIFPHQDLGPIPAVRIVILIAVSTALYGLLTTLYNLFLHPLRSVPGPFLARVSCIAICSPLWNTYIALTAQQ
PFRIKEAHERYGPIIRIGPNELHFASPTAMTKIYAQGKGAPLKAGFYSHAIPIKEQHSFSMVDKHQHLARKKLISRFFSP
SHQAKFLEGVKELSIDLNRLLARKASESVDNVVDVYHLLNMFTFESVYLLSFEEPLRMMKTGEEHRLMHLANRTAASLVI
AVILPFTRQFLYRIPGRMFDDFRAVHEWKQYYIDRMRALTKSSQSPFLSQLLNTTSEEHNRPLNESEAAEELIALMFAGS
ETVGVTMNWLLWELAHHPEVQEKLFKEICEVMPSPTSSVPYDELANLPFLRAVIKETLRVHTAILGPFPRVAVEDMVIEG
QAVPKGSVVNMCTYVTHRDPNYFPDPERWVPSRWIDGDAGAMKVAFAPFSTGPRVCMGQGLALAEMTSLV
PTVCRRFKFSLAGDKWPKGDMSPIGAFTTRPKGETNYLRVEDRI*
>CYP5291A1 Aspergillus terreus
37% to CYP512G2
ATEG_10278.1
MFVSTSLMYCYYILGLK (0)
AKVPGVGYPKFPIFASWIAAYRFLRDPVGLVREGVEKYKRSP
FRISTLQGEYVLIPSREMVSEYIRAPDSVLSFQDGAND (0)
QQQIPFTMGYGVAYRTYHVPVVRMNLTKSILHQISTIWEEIECAFDDHIGSPKEYQPFPLYQIMAMTIARASNRIFINEEFARNKEY
LQLAVDYAQAVVISAELLKPFPDWMKQYEKQKPELLSSSRILVKAVPVSSCRRRALKYLRQVVQECLDRKPGDERPDTMI
QWLADAAPPAERKLDLLVERIMALNVAAIHTTTM (0)
TLTGALHNLASEPDKYLPQLREEVEQQCANGPTKETLTNLHK
IDSFLKEAGRFNNAGL (1)
MAMQRNAKQK
FTFSDGTIIPAGAKIGTPSLILHRDPTAYEDGDAFDGFRFSKKGAAASSPREAAKFSMVSTAAEYQIFGHGKHACPGRFY
AVNEMKIMLAIFISRYEIKAVPGTAPKQTFLATMAIPDTQLETLVKRRET
>CYP5292A1 Aspergillus terreus
35% to CYP58M2
ATEG_02670.1
MILLTPDMLMLVVACFILAQAFKY
IYRLKFHQLARFPGPRLAAASSLYATYHNWIERGAFTERLPWLHDLY
(1)
GPIVRTHPNELHIRDISAYNEIFRVGTPFKKEGRFYGFPFEGSHF
SMPDIESAKTRRSLLQPHLSDRSVKQIQPVLEQSINQFSRILQNASG
YKPGVDLSLGYRSVTIDMLLRYGFGKSLKSLDAGSFNCEMAEDMDDVLFGSLIAKHFPNM
GKAVFELLLQLPLAIAKMVKVSSILEMRKVCF (0)
PNIEDNSNPRIFDTAV
KELISDSRRLSIDELTAEAVVLLFAGGEATAISVIIGTFHLLSDP
ERLHTLKQELLSAMPDGQSLALSELERLPYL (0)
RGVVKEALRFTQGAPGRLPRVVPSEGATLGGEFIPGK (0)
TIVSSSHYVYHFDPQIFDDPFAFKPERWLDENNAQHLDKYMLSFSRGSRGCIGIN
(2)
LAYAELYLIFAHVMRKFDLSLNGTTLDDMTLRDYYAPMARGHLKVRVDGYDRRMHIEG*
>CYP5293A1 Aspergillus terreus
42% to CYP5286A1 Aspergillus flavus
43% to CYP5237A1 Uncinocarpus
reesii
41% to CYP685A2 Neosartorya fischeri
ATEG_01795.1
MHSLFGTTILVVLIAIYTRYYRN (0)
ISHDFKDSQGRRIKQLKKDTRYLRFSHG (2)
RELSQEGSELAGEEPYLMRNGWWTRELVITHPDHLREFYRKDAK
()
HQKPVNMNLGDYFGR (2?)
LLGQCLGLQGGQKWTVMRAHFEPEFSHLASMN
MADTFAMEIEKWALTLSKGGDLHQQEATPGSFYRNPTE ()
ACRYLPFRLTGLTVYGDALDDE (0)
TYQDLVHLNDLHEQVMLDAF
FGRFTVSKIFNILPTQSRRRLETFKARWEKLNLDIIAKART (0)
KQLHCPAERIYKGVESGKMSKVE (0)
PQFLETMDELLFTNIDVTSTVLAFLLINIAANQSFQSSVRE
EIAAKQSQPSYNLRDYVLEKESLLHYAAMESVRMSPALWFSLPEKTAAEKVIGGYLIPAQTPVVIDWKR
LNTTPAIWGSDGEQFRPERFADISPTAYRYGLLRFGIGRGRCLGKNIADMMLKMVTVAIVQRYFMKPAG
REKGTRQDRFTVTSEEEIVFTPIRSLNACA
>CYP5293A2 Aspergillus terreus
62% to CYP5293A1 Aspergillus terreus
ATEG_04640.1 revised
MKSIVLNLTSPAATVYGAYYLLDSRLGSLLVTAVLSILLGVYTRHFQN (0)
TSKHFRDVSGRKIKKLKGDTRYLRFSHG (2)
LEMSQEGQDMAGEEPYLVHNGWTRELVVTQPEHVQEFYRKDGKDHMKGKNLNLGDAFGRLLGRSAGVQGGRKWVAIRAHFDP
EFSHSSSVYMSDIFATEISQWVTELSQGSADNPHPISRFVRNAAEACHFLPFRLIALTAYGDALDTKTYQELVHLNDLHE
PLMLDAIFGKWTPYKLFNFLPTEFRSRLKKFERSWERLNDEVLAKARE
(0)
NNLRCPALRIFDGVESGDIYKVE (0)
EFLQTMYELLYTNIDVTSTVTSFLLLNISANQS
FQSKLREEIQARQNEPSYKLMDYVEKKDTLLHYAVMESLRMSPALWFSLPEKTATDKIIGGYHIPAGTPTIIDWKRLNTT
PEIWGADSEVFCPERFASISPTAYRYAFLRFGIGSRRCMGQNIAIVMLKMAVIEVLKRYSMKVGYDSGIRNDRFTVTSEG
EIEFMSIEGED
>CYP5294A1 Aspergillus terreus
34% to CYP5068B1
ATEG_06474.1
MAVNLPIPFILLLLLFLPLLLPLLRRKHDLPLPLLGNLHQQSWSEPWKTYREWHEMYGPLISFKIGPYQVISVGNHQVAK
DLLERRGAIYSSRPESVWSQYMTKGLQPVFQSYTNSWKLIHKLQMPLLSTVAINAYLPLLDLETRQLLIDLLLPQFISGP
LARFAFSTASCLLTGERVKSAVAVSFHEAKDVIDGFFKDIHWTYILLDLIPGVKYMPSWLIKFKQVSDAFYQNAVRTYNR
LFGRAIHLREWTWVRAVMSHRDAQKTTWEQICFALGELWTAMSVTTPVMLMVFTRLSLLNRDRFLQLQQEIDSVCGPNRL
PSQELVEHLPYLNAYILEILRLDTLIPLGFLRSVDKDDEYMGYRIPANTIIIPNTWCLDHDESLYPDPYGFHPERWLADP
DLPLGAFGFGRRKCPGRFLATRSLQLAIARIAWAFNLVWNAGPIPTSPRYAGMILRPRDFLGVFQPRSLERRAVIEQEWS
DGERLEDHYTDFQMT*
>CYP5295A1 Aspergillus terreus
41% to CYP5069A1 Neosartorya fischeri
42% to CYP5050A1 Nectria haematococca
ATEG_06204.1 no introns
MTDDIAPSGYQPHRISTLAVLIGFIALLTAWLRRDRRLASIPGPRTYPLVGLGYKLPPKAPALFRKWAMEYGDVFRIRVG
WYDWVVINSPEAIAEILEKQAVKTSSKAPSPLGHDVVTGGNRMPTMPYGKEWRNLRSVVRQITTVPMTASFVPSQEFEAKQLLFDLATDNENQRNFYQHMRRYAFSIIMTNTFGTRVKSWDHPDAQN
AVRSQAVLRRTSRPGAFLVDELPPLARLPKWLQPGRREAQRAAKVVHDIKMELWERLKTQ
VETGKAPHCYAREIYESRESWYAKGATEEQLAWVSGGLVEAGFETTAGTLNSLVLYLAAN
PQVQKTAQEELMRAVGPHRLPTFEDTRRLPYIRACVKEVLRMNPILSPGIRHYADEDVVY
KEHVIPKGTVLLANTAYLHYDPRRYKDPQKFMPERYLDHPLYSSDYAAMTDPSRRDHFTF
STGRRTCPGARLAENSLTIALAGMLWAFEIRPGLVDGVETEVDMSDDAYLDTGFTLPKPF
AARFLPWSEERLQIVKEQWELASKKGYELRGVPVDIEGMTK*
>CYP5296A1 Aspergillus terreus
35% to CYP5049A1 Nectria haematococca
ATEG_08476.1
MVLLHLLFLSAVGVAVFG (0)
PKPPHSAVWGHLKLFNNI
MNQFPPNTAIATYYTEISHKYQLKGIFYLDLWPFGPSQMVLVHPNAAEHVTTVENYPLHDEVSRYLTPLLGEHAIGASDG
ERWKMLHRILTPAFKPSKTKAMAPVIAEQVSLLLHPTLTQYAGSAEVFSMEECAARLVFSISSTVILGNSVSEDENAQLI
SDINAVVDYATMLTLTAATNPLSKVRKWWKKRAAIQRMDSFLRLLIKGRYAQLAHGKVDVNRADSTILDAIL
ANVQSMRCVPHGFAAPDSELQIVTDN (2)
VKGLLLGGYGTTADTLC (0)
YVFIVLHFHPPVVQNLRDEHDRIFSRDINA
IRKVLEQTPHKLNELHYTTAVVKETLRLFPVGFGARKAKQG (2)
STTLTYNGITYPTTNQMIIPC &
HTIHYDPEIIFPHPTKFNPARFLEPDLASMPRNAWRPFERGARMCPGRDLAMD
GLRIILLLTVREYKFQCADVDHLVKSMPGVQHTDMDAVMGDLAFQEMGFSAKARGGAMMRVSLMQSY*
>CYP5297A1 Aspergillus terreus
ATEG_03567.1
MSISNMTSTVWPGTPRTLLTAAFMDLM (1)
NLQVPAIEHNHLPILTVALLTGIASA
(0)
RPRLLDAYRSGVWWRIFVPRLVPYIEEGYHKVGAL
(0)
YNKNDQPFRIWLGGFQAYAYVLPERYLDKIKN
MPESEASFAAMANKYFHTGLPTGEVNNLVLQVASKLVNGNLATIKTLMQGEVQKALAREIGSPRQWTKINAWQVARKTTE
APGLRVVFGEELANDKTFVTGVSEFVSNITVYAFTLRYINLGPLRDFILYLVHWRHRRSLPAVLTPLNNVITERKKVRSN
RHISDDEESFDCIQWALDQPVSDDCKTAEAIARRLVVISLGTIDTVAGVLVKQLTHLASHPECHEEIRAEIRECLAEDDN
GWTLKSTGRMKKLESFIQESLRMSSGAISLSGMRIVTGSGFRLDDNTVLPRDSFIAIPTRNILYDPEVFPEPEKFDPFRF
YKIKEDEKNAGSRSNRRDIRASWLAFGYGRQACPGRFYAINAMKTILGEILLKYDIRLAEKQAPRIDIDLDPMLAPVRST
DLEFRVRA
>CYP5298A1 Mycosphaerella fijiensis
34% to CYP596A1 Magnaporthe grisea
estExt_fgenesh1_pg.C_30530
MDSFPSLVTLASICLLCTLVAIYIHRIRTTKQHLAALPIADTGDVDPVQAFITNGRSVLETALREHTGAFAIHTSNGTRV
VIRHGFAEEYTKSKSMSGVETLRVDGFADYPGFQAAKAAMDSPLLRNMLVRRLSPSLASVRIDMQDELDLATQDVLGGVS
SEWTSTVIQPMVGTLAARLVSRVLVGKPLCHDKRWVKATENYTRLNFAAASELRQVRSFLRPFKHWWLPSCVELRRAAYE
ARRLIASEVSRREKVDHETRQRGKEPTPRADGLQWLLEESRSLKMKPDITAAELHLSLIGVQTVAHSLGQALRLLCEHPE
WATRLRHEATTTLERHGSWNKAAMYELKQHDSFLKESQRLTTGYLALNSIVTRDMVLSDGTTLPRGTRCFLEAGLLSGNR
YPSPHEFDPTRFLHTQNHDAEAPSAVPRSNYSSATVEHLGFGFGPRACPGRFWASDLMKMTMAHLVLHYDWEPEQGNDTP
TLMEIESIQLMHPEAKLRVRRRVPVQA*
>CYP5298B1 Mycosphaerella fijiensis
38% TO CYP5298A1 Mycosphaerella fijiensis
36% TO CYP596B1 Nectria haematococca
gw1.3.810.1
MLPFTIMEVYDLLQPQYCIAVATLCFILIWCVRAIWEWYGTEKYPFATLGD
EDPLES
WVKNGTQLIEEGLRKFPGPFHIRTGTGPKLIVRNRCAQEFAKHPALSVAEALRSDSFADYPGFEAAKVSVHSQVVRDTLL
RRVTPALDSLRGKLVADAEVSILE
NFGESSEWTTASVQPLILDVVAKMSSRPFVGDRLCRDPEWLEVQKQYAGLSAVAASELRNCSVLFRRVRHWMLPSCRS
LRRLVRDARALYAKEMRVRSESTSVGKSIGDTDSISWLEKESRVSNVHVDIVAAQLQLSMVAIQTTSHVLCHALLHACEH
SKFIEPLRNEAIEVIGKHGWSKAGLYHLKLMDCFLKESLRVSQGRLAMARVATEKIVFSDGTVVPKGTGCMLEANFQHEN
PYAYPEHFDPSRYAQMRNEAGETQSWQYVSSSPDDQGFGYGLHSCPGKFFANNVVKVAFAHLLMFYDW
SLDSNDENHTLEAESVKTVNPNFQLRFRRRKSSAQAA
>CYP5299A1 Mycosphaerella fijiensis
31% to CYP5107A1 Aspergillus flavus
e_gw1.6.409.1
MEFPSILQTCFHYIGRLLLHPYAFYIYYSIAALLALILAVVAIFVIQVSIRISRERQDIAWAGLQNKRIFPKLRACLREL
SAGRGPVNEGYDKYSRYGLPFITPALRWSAIVLPPSSSAWVAQQPESVLSGNKNLKDVMGPEWLLHGPNADSVLDFSVIR
RDLTRQITRLSDQVLEEIQHAFDEKLRFDGEEWNDFSATKLLSCVSFRAANRIFVGLPLCRDAGYEKDVMRWTSCFGIST
IIMAFLIPKVLQPSLMPMVSVPARLMQWWATRHLRPKIRERLATLEARGQANGKMLAEDEKPNDMLQWIIDTNCQKQDPR
ELEPANIAGKLILFNIFATATTSTMAGVVLTDILAYENASDLLSELREEAEHYMPLVEHDATAIRSMTKLDSVIRESLRF
NPMGAQGMAREVVAPGGVTTPDGLYLTQGSHIQCTIGPMQRDVDLFGSSADEYDPLRHHRQAQDNGLPEDESVAEAGKRK
GAVQINSQFLSWGLGRHACPGRFFAVHTMKLMLGYLLVHHDIQPFEKKPELFEIGEARVPSDKQMIRVKRRLVPGIEKPP
G*
>CYP5299A2P Mycosphaerella graminicola
45% to CYP5299A1 Mycosphaerella fijiensis
e_gw.7.555.1
not in the Kelly set
MWLIMHLILRLLLYLAVFLAA
LIANVVATRIIRIPNQTIPGVP*VGLKDRKIFPGLRACLGELGAGRAAIEEG
()
HDQYGKRGRPFMLPGLEWSTVVLPPHLADWMLRQSDSVLSDVTPMSDAIGAKYLGH
(1)
GPGEASVLDFTVLRR ()
SRHTAKLVRQVQDEIDVAFDAYLNTNTEGQWKEVKIKPVIESVVFNTTNRIFVGLPLCRS
ERFKKAINRWTMALGIGLLFCRYLIPGPMRPLITPVIAAPANFFIWRAVSYLTPTIKDRI
LEKNLCRASTKTSCNSQPNDMVQWIVDHNAQKADPAELKPSNIAG*IILLNLFAFGT
TTMIGTVALIDILSYKNAPTLLAELREEADRVLPLLEHDSTAIR
()
SMTKLDSVIRETLRLHPLNAQGMVREVVAIGGPETPDGLLLPQGTHISLLTSTMHSDPDVSGGDTAEYDPLRFYKQGLGGG
QTAAVQVSEGYLSFGLGEHACPGRFFAVNVIKLMLAHLLVRYDIEPFAERPGFTALAGAMIPKAKTKVKMRKRSVIV*
>CYP5300A1 Mycosphaerella fijiensis
37% to CYP68L6 Aspergillus terreus
36% to CYP68D1 N. crassa
e_gw1.2.689.1
MIPSPHEKDYFWFVTKSTRAEFLSEAARLLRKGFASADVIRLHAGWDHIVVLSPFYAERVRADDKLSPDTFSDKEMFGEV
PGFEPYRFLCTHRDLIRNVISMRLNRCFGAYPLILSLSLTAPLITSGGPEWRRVPLGTAVLRVLTQSTSRALQGPELSYD
EEWLEIATQYTLTSITGVTTLRRLPRFLVPVLHWYVPDAIKSRQLLSRARAKLLPIYEKRKHELCQAINSGTYRPEDADA
LGWYEELANGRDYDPVVAQLTVAVAAIHTTTDFMCQFLSDLVRYPEYIQPLREELILALQDKGWKASTILQLPLLDSIMK
ESQRLKPISIAFMRSIAQHDIALEDDVTIPQDTSVIVSAHAMRDSTLYENPDDFDGYRFVNPAKNHESRHFTSVSVGHMG
FGFGKHACPGRFFVNLQTKIFIAHMLLKYDWKFATEGGPAIRTSGFDQVIDPSAEMLIRRRREEIQIEALYG*
>CYP5301A1 Mycosphaerella fijiensis
38% to CYP5265A1 Fusarium oxysporum
33% to CYP609A1 Magnaporthe grisea
estExt_fgenesh1_pg.C_130049
MAIFEALDRLVTTSLAIPFFSLLAIGFIFSYLFQKPSFPSNAPPLTKESWPIIGSPAFFSERWSFYQRAHKASKSGHFSF
YAGQNPVIGLSAVEESSRRLFFDSKALSAAEAYSVLLAGVPTVKRNIVVNPKSEDLNLTDKDAKLRYRMITMMKSEKLSG
CIPWMIKDVRNALDELKKDPKAFTDPFQSIYRIVFQLTVRLSACDELADDPVLREQTLHYFEQIAGATSPLTIMFPWIPS
WGKVMRTYGGVRLFMIFKKLTDQRKVGDKFNDTLQMLVNLKDTPVAVIEFVISSLFAGQNNTGIQGAWILTQLAHNIEWQ
RRVREEVVAVANEYCHDTELPLAERLSKVPFDAWDKEFPMIYLCLRETMRLGMPGTAFRKNISDQNILIPGTEEVIPPNT
YVAMHVFDAHLNADVYDEPIKWDPSRYLPDRAEDKRQIYSWMGWGHGRHPCLGIRFARLEINMIIAFWFAYFEEFEHLDA
AGNKASEAPAFNNDDVGTHLPQSKVYLKYNPS*
>CYP5301A2P Mycosphaerella fijiensis
46% to CYP5301A1 Mycosphaerella fijiensis
fgenesh1_pg.C_scaffold_71000004 revised
IIRFVIGALFGGLLNSGINAAWSVCYLANNDYWMQRVREEIDEVAERHCRDHSLPLK
DRLMRVPIEAWETEFPMIDLCLKESIRLQLKGTDFRQNLTNQEIAINKRGEVIPPGAYVAIATADIHYDPNIYPEPERFD
PGRYLPDRAEDKKEQYGWM (?)
GLARHPCVVMKFAKLEKNIIVAFFLAYFSDIQLADQTGQPKAEVSRTDLNRHSASKPETHMFLRYQVRQD*
>CYP5302A1 Mycosphaerella fijiensis
32% to CYP611A2 Uncinocarpus reesii
e_gw1.13.371.1
MHSFLVITLSLVAFAVSVIALLQWLISPRRDPREPPYLPTSTPIFGHLFGVLGQGADYYCLMDEKYPGIGLYGLPMLNGR
MYIVSSAEWATALEKRSNRSVSLELMIVDVVGKVFCFDEKTVAILKDNLFGEDGSRPNLVMENHKLIHASLAPGDELEEL
KVRTLGNVSKHVNTLAQAVDTGDRNVLGLWSWIREHLSQSALQAFYGLDSPVTADSALMKDFWIWEENIQVLMMSPAPSI
LARDAFLARERWLRAWEKYVQQGRYKGASKFIQDRVALHMKEFDLTEEAYGRVESGTPHALLVNMVPSSFWFISYIFQDP
TLLAEIRQEIDRCIAKNGSRYELNVSKLRTSCPLFGSTFKETLRIVAPLHTNRVIAEDTLVTHPGTGQTCLLKKGATIQY
ASTLIHKNESVWGEDANSFQARRFLPMFEKMHTGSFRSFGGGFNVCPGRHFAEAEVQGIAALFCAAFDMHGKDGQAFATP
PVEKANGFLFTAAVKPAHDVQVRLARRKGYVGVQWQLTL*
>CYP5303A1 Mycosphaerella fijiensis
36% to CYP5128B1 Phaeosphaeria nodorum
fgenesh1_pm.C_scaffold_9000099
MLAVIISLLLVIGYLFSLAYRVSPWHPLSHIPGPWRTAISSLWLQYHTFHGTQGKATRRLHHIYGPIVRVGPNEVEIADG
AALWPIYIKNGGFDKSHHYAMLDIDGHSTVFSTLQNRKRADRLKVALPFFSAASAQRQVPMLKAYAVKLAERLERDKIRG
DTVDLLDRCRSYSLDTTSSYVFGEAFGAMEEDKMSIAPVVDNFVEVNLLFNIPSRFYRIFSFCYNAFVVKTAVKQADAKV
DKWIRDVVVRNLGKSPEAQKTYPGRLAALGMPLNAVVPEGKDAIFGATDALGLALSLILWRLASNTAVYAALREELESNA
GMQDEKLQSLPILTGIIKEVMRLSSTVPCKLPRVTPREGMIYKDIYIPGNVVVGVAPCILHFNEQVYPEPYTFRYQRWQD
ATEEMSRDWMPFGKGARACLGRHLAMLQLCVAVSTVVRSGVLNNARTMKSSIEFWEWYNVKVAGGTIEIGWQESPEVTDDV*
>CYP5304A1 Mycosphaerella fijiensis
31% to CYP5104B1 Aspergillus niger
estExt_Genewise1Plus.C_210305
MWLLYLPTALIFAYFLYNRYFHPLHKIPGPFLASITPLWLVYQCYHRRRPRLDMELHKAYGSIVRISPNEIMFSNPDHFR
EVYGAGTKFTKSRFYEAPTDPVQEAGWEKLDMLVEKDIEKLRVQKRFAGPIYSISNALKHEHLIDNNILRSLQRFRTLSS
SKSVDIYSEFEILNVDIMSEFTFGKAYGAVEKGSDDGHMASMDSMWAWWGWIGFLPWLNEIDKIYSPWASMIFGGSAEKK
FPVFSYAISQITAYETASASGQKVPVPCLLDDLRTLSRTRPEFKDNWGMRLALTDLGAGVDTMSWTLSAFIVGIAQNPSV
YQKLKSELDSSGLNSKDATPVPYETAASLPYFQACLHECQRMWPNIAVSIPRDVPAGGIEIDGYFIPEGYTVGMNSKVLG
WSGEVFGREPERFRPERWLEADKAQRDSMENKNLSFGGSARKCPGMHVAWVCMSKVLASLYANFEVKLLNELDGKPGPAG
HVWREHGSFPTKWHGLEVELIAR
>CYP5305A1P Mycosphaerella fijiensis
40% to CYP5243A1 Coccidioides immitis
e_gw1.29.27.1
seq. is short where the XXX are but there is
no intron seq there so the
length cannot be made any longer. I suspect this may be a pseudogene.
MEISTFLVPTLLALSLYRFFTVGRFEAPALLTTYIFLSSILPFAKNAYTASRTGMPRIHVFWHPHSFIWMVAGVPLRPYL
KHYLPNWIWDRLAPTIYGWEFQEGMRPFENFAAPQGDRKTFWLVSCGAELELYTWDRDIVKQVLMRHQYFHQLKLTAFFL
EKFGKSLFTSNGESWARQRKVLAAVVNEKISKTVFGETVRQAEGLVEEVIRKDAMSGGKGVAETNRI
XXXXXXXX
FDMLKKVTIHVLSGAGMGTTVSWSNDGGEKKLKPGMKMDYMD
XXXXXXXX
ACKIVTGATMGPIILPQWFT
SNYPSFLPGHDFMRNLSIAMREFPVHTGDLLNLE
XXXXXXXXXXXXXXXXX
RERQRNTSAAASTTGNAMSALLQHAKTEENPNGLTEDEIRGNLFIFTVAGFETTANTLSYTIMLLILHPSWQKWLFE
EIDSIIPASGPTDEELDYQTLFPKCQRILAFMFETLRFHPPLVHIVKETQGEQILVTEKGKE
XXXXXXX
LRVPDGTLVYLDAVALHLDPE (0)
FRPTRWLHQSSDSKITMFAPPKGSFLSWSMGPRGCPGQKMSQVEFVA (0)
FDGESDEEATARIERWVANSFSKATLEMSGVYDISGEEVGFRVGLRRRR*
>CYP5306A1 Mycosphaerella fijiensis
32% to CYP52G2 Aspergillus fumigatus
gw1.9.152.1 revised at N-term
MAAAIYVIAAQLQPPDTRFHYLAASLVTIWLLRKLARLSTAYISSKRFFTFAER
NGCVATTGLPTPFLSSLRHKLSLLLYVGDDLLDNVFSRKFNTYGATHALHDPFGVPKVIH
TIDPVNLNAILNKSHTDWAPSKSRARTMYPLAQEGLLNSEGEAWHKNRKMVMRHIGTKRAKDVRHSEGDIQLLFTAIGPT
EQDGWTGVVDLLDLFHRLSLDMSTTFLLGTSADSQLNGMRETRLKAAMEEFDLVPSKRSKAKMSYGVAYETVRNHFSRRS
KLGSKYWMADGLRYRKACATLNKFADDLIARAIDRRKGVPEGVDVAEFGLVDSLVKDIGDPIQIRNLVMDLFIAGQNMTG
TMAAWVFAQLEAHPDIFQRVRAEVLEKFGPEEAPLAPLTWDNLRSCTTMQHVILETLRMYPLLANIGRNAKRDTVLPRGG
GEDGMQPMAVPKGAAVTANVYLMHRREEEWGEDAWEFQPDRWIGRKISADYAPFGMGPRICVGQQLTMTEISYLMARMMQ
HFCDMKAPEGQNNLTKGYRVVVAPKNGVKARLRRA*
>CYP5307A1 Mycosphaerella fijiensis
35% to CYP583A1 Magnaporthe grisea
fgenesh1_pm.C_scaffold_1000175
MPPLIPFSRLSWSCLSALSCKILLNLLILTL
MSLLWQVTYSLLFDPLRNIPGPVLAKCSSLWLRYQRWHGQLSLTADSLLAKYDTSILRLSPDLVLINDSEAVEKAFNRRD
LDTSPESIRALRVGGHDWTVTYPQYGVARQRRHPVMIASTTKNLKARHDVWRENVLKMVTDIDRSQGERSEDIVRHLRIC
TLKSSQVLIGGPGVQLETEEFPRIVGEYNFLVVWRLCLPEWTFEWLKHFSLLERVWYRVRSSDMLFDLG
VDICRQAEVNRDVEAPNAAPNVYELCVDPDAKYPAQSWTKNELG
AEMAGQVLAATETTSSALAFIYYELAKNARLQQELYQELARADTDEELDSLKLLDACIKEGLRFR
PPVALTGSRLVPAGGVEVCGHYLPEGTVITTQSLSMSRQRRDLFPDYDTYNAQRWLIEDGKSAERKRLLVPFGVGSRRCP
GGNMALYQMRMILYHTIRAFDVRLAPETTPEKMEPFEANGYRSRHDRCDLIFVPRSVGGGK*
>CYP5308A1 Mycosphaerella fijiensis
fgenesh1_pg.C_scaffold_9000171
33% to CYP504A13
MSSILSGFEHPAYAIGAYVSGVLLLIYLLVSKYGVSFCAAHRSCLCKYEAF
ATNFPKIEGLPEVPNGLPFIGHLAALGGRRKKNDSTVYAEWARQLNTDIFQCRLGYQRTVVVN
(1)
SAMKDMWVGQSDSLSDRPNQPEFVEKLGVDITGTSLTPQ
IRKCRMAGMRALGIPNWPKYYHLVEPTSVALIRDMYDKGQTGKIPTDVYYHLRHVVFDLA
LSLTSGARFGEVNDAFMTRFLWSINAISAVRNSTKTFRHFVPILRWIRQSTTETIMAEKV
RAHTEVSYGSFQKRVEAGETVDCIVNSLGEDKLSDDEIHSTCLSLLAAPDTVASSVYQ
GVAWLSSPEGQSAQEAVYEAILTAYSGDRSAAWNGAFREEKVPLLVSLYKETMRFFIIAP
FAIPRQASQDIEHRGIKIPKGMAVILNSQAVSHDTDQFGDDAWHFNPERYLDDDSPLPHS
AFGAGSRICPAVGISNRLTYAILTRLILAFRFREPVDGMGRTPDLHPINFSDVYEQIVSQ
SLVATQVWMKS*
>CYP5309A1 Mycosphaerella fijiensis
note: EXXR (ECIR) and PERF (PARW) motifs are
present but no heme Cys is found
gene model has long C-term, probably
incorrectly fused two genes
seems to be missing some seq where the XXX are
shown
synt_with_mycgr.5__2
MDHIVNMIKNFFGNLPTFGPAIENVLKKLPVFGPIFRNLFNGFSGNRVAKVTFLWKLYHQLVGDYQTKLKVLHERH
(1)
GPIVQVAPGEFSVS
xxxxxxxxxxxxxxxxxxxxxxxxxx
GKEGSLRFIGRLPASTQGLLNPPAIKVLQDACKMQNLFDRERVIDGRNQALQQHFVNAANDQRQIDLTKL
FARYAYDLVITTTTGKPAGFLDINADPAKIDSAIKNWKFDAIIVGSYLRYNKYIKPKRENRLFSSVSEASTATTDEKLAA
THDTDGISPLHEIKPSSLINASDHEAMTVLALAAADPAIILVTKALSYVYNNHDILHSLRAEFKASGISHVPTFKELILN
KSRLPLLHAVLLECIRLHPIYISGLSYIAPDDGFRANGLEIPAGNLITPTCVVEHVNPEAFGNSGVWDPARWLNGATAEL
KRLLPAFNLDNGRGANPDTVAEFHSLIASKIIIQVVTNFDIAGDS
LKTAKIAVADGAQNAASITEASNDRVGQTTPATLG
AMDRLEQYLGADGVRLLLTRFNPDATGRGSWGREPLRVGP
LGTRDDFYDLLRSVKSIYGGRLSLDQAPDKTVVIGTKAMI
EYTKNKAKTTTTRPVSQPIKKQESVPAAGKRLVVGAWGEFAVKEHERQEGFKTKESWEAQKKQNEEAAQEAKASPPAQAP
QFKATWKQTGIGANGKRKVVSTQTTLEPSASPAPVAAPRTLPPHLRKAAAGPAN
>CYP5310A1P Mycosphaerella fijiensis
28% TO CYP642A2, 28% TO CYP660B1
fgenesh1_pg.C_scaffold_1001253
ARQTAAARKALYDLLLSWYQSGGLKTASEEMKAIVTVFERAKSPPDVGTKFLNMMMIAFL
ANTPETLGWLMMYLVQAPELFKVIKAECDALGESLVTLNFKSATPHLYSAFFETFRMYVFTGTPATVTKPCTLPGMGDHV
FQPGDILHSFAEACAMDVEIYGSDVEYWKGHRFVGEGEALLKYDLTFGLGRS (1)
PCPGRNFAIIELCMLAARMIKTFD
>CYP5311A1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
35% to CYP5213A1 Rhizopus oryzae
fgeneshPB_pg.33__108
MIEYLKEFVDRIDSKTLENVKSLAFSKEGAIGISTAIILSSAYNYHKWSSRTISNGCPRVPHTLPFVGLTRVYRKDSKAF
CEEWHAKLGPVFRAHLFGKEVTVVSGHYVREVFLNKHFDFVKGVAKVFDTRLLTDSGSREDFTPEDLREIITKYLTPKLN
FYTKRVIKRLKQGVESSLGDKDSIELDNLYPFVQHLVVNASASIFVGEELSQNKLLIDSFKNMVRDVGKEIKQNPWFEPF
PTINKFRMWLIGKTSPVIKNHKEQLLNAIKPEVEYRLSQARSNPDWKKPTDMLQDLLENSKPPAHLDLMDHLVHIITFLI
FVALHTTSENTTVLLYRMLENPAIVDELVIEQQEVLEQEGLDANCGSEVFTRDILKKFVKLDSVCRETFRMKNQYISLPH
EYDGKVPLTLSNGAVINPGEDVLIDVWTNHQYTEDANDVEDADQFKAFRFVDQDKQSTKVGEDYLFFGMGRRACPGRWFA
IQEVQTILAMLVREYKFMPKGPIVFPTEERSPIPTGKCIIQRK*
>CYP5311A2 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
81% to CYP5311A1
fgeneshPB_pg.45__88
MIEYLKELVDRMNSKTLANLKRLVFSKKGGIGIIMAIILSSVYNYHKWSSRTISNGCPRVPHTLPFFGLTKVYRKDSKAF
CEEWHAKLGPVFRAHLFGKEVTVVSGHYVREVFLNKHFDFIKGIVKVFDTRLLTDNGSREDFPPEDLREIITKYLTPKLN
IYTRRLIKQLKQDVENILGLIEFDNLYPFVQHLIVNASASIFLGEENSQNKLLIDSIKNMVRLVGSEVKQNPWIEPFSPI
KKIRMWVIGKTSPVIRSYKEQLINAIKPVVEYRLSEARRNPDWKKPTDVLQDLLENSKPPAHMDLMDYLVCIITILIFVA
LHSTIENTTVLLYRILENPEIMDELDLEQREVIEQEGLDTNCGSELFTRDILKKFTKLDSVCRETFRMKNQYITLPHEYD
GKVPLTLSNGAVINPGDDVLIDVWTNHRYKKETTSVKDADEFRPFRFVNQNKQSTKVGEDYLFFGMGRHACPGRWFAMQE
IQAITAILVRECKFIPKGPIIFPTAERSPIPTGRYINFCKNGFNKKFLNRTIKHAILYNSIEAFCIKFIFAKVDTLQSLG
VLIDLFAEFNFFQKLKHLDGSHRRVLKYYEIFLADVQIWIYR*
>CYP5311A3 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
55% to CYP5311A1 Phycomyces blakesleeanus
e_gw1.10.197.1
MLQYVKELVDRLDNKKLEQIKEVATSKEGVIGITASIVLATAYSYHKHTTRP
(0)
VSNGSPLVPYTFPLVGSTMEYRKSPEAFCRKWHEKLGPVFRAHLFGK
(0)
EVTVIGGHEVKEVFLDKHFDFFAALDK (0)
TFNLRLLTGGGRPEDFKADPIRKIVTKYLTPNLDFYTDRVVKRVNRANLVNT
(2)
CVIIDSKEFFSVYPLVQHMVAKASASIFVGENLANNAL
LIDSFKNMVIDVGSELIPIPWIEPFPTLVYIRMW (2)
YFGKNAPSTRRHKQQLRAAIGPELEDRIHQMNTNPEWKRP (0)
NDILQDIIEKEEHPSDIPYIDFIITMITAIIFASIHTTSEAATTVLYRILDNPEVIEALRE
EQDQVFRKEGIDENAGAEVFTRSIIKQFVKLDSVCR
ESSRLKNEFIKLPHAYEGTTPLKLSNGAIIKP (1)
GEEVLIDIWKNHRDPEIQNDLKDVEQFKPFRFVSSEKQATKVGEDFLVFGMGRHACPGRW
FAMQEVETIISMIIREYDIKATTPVTYPKSERGMPGGKFRLEKRKL*
>CYP5312A1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
28% to CYP5311A1 Phycomyces blakesleeanus
estExt_fgeneshPB_pg.C_150247
MTDTTISRSIETVLKIVNDISPRIASAYQTTTRNELILVGGAALFSVYNLVQYIKDKSTAKYYLPPRVPFALPLVGHSLY
LLWDSNQFIDWCAKKYGEVYEISIMGKIVTVASGLSGQEALKADTDFLSLEEGVIKDVLYLQYAIDKTTFEIGFYVNPVV
AKAVISHKKVPRHTEGILKGMDAGFKNLLPATDSFVLKDPNHFFQRLIAHMSVPTLIGKEVGDNATVIESFAAFTADVTD
NIPIFMSVPVVFHRFITPYLQSFKRHRVIMSKFIAPVVESRRQAADAAKLKGETYKAEDDFLQGLLEFVKPDGTNYTADQ
VAQATLLVAFASVHTTATNLAFCAYWIVSRPDIKQAILEEIESVVGKDINTELTYEHFENMPYLDKVIRESVRQGADVLA
VGKKCLKTFTFSNGYQVPAGRVVETTNRRLNMGLSANRVDISEMDPLESGSRPPTTASRDYVTFGMGKHLCPGRFFAVLE
IKLTIIQLLRQYDITPSTSSPAHPVKLIGGFMATNSSAPIRFTKRKL*
>CYP5313A1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
55% to CYP5313A2 Phycomyces blakesleeanus
33% to CYP576A3 Aspergillus terreus
fgeneshPB_pg.2__19 revised with gc boundary
after PLLNN
MNHIEAFSKYFIFTFPENINFTQVGKIAATGLKIQSAFFSPLGDIPGPFSKRFFEGSYFSKKKPGKRDYHNKYGHLVRIG
PSKISVSDKDIIKQIMVTEDFEKSSIYSKMKGKDEWNT
FNMIDKDTHKQRRRLVSSAFSIKYIKSLEPLFESVTESFVKR
INLDTERTKEGDEFGVIDIWQLLRCLTLDVIGETAFGGTFNMLENDDHAVSRAIVKLTRGVEF
(0)
SILHPWLTNLILMIRPEGQPLLNN (0)
FVSNIISERTHSKEKRNDILQILVDTQHAKNTKDRMNSRQIASETGLFLIAGSETTSNTIGFALIEMCRNTDVLTELYAEIDKVDLD
EGRILFHQEQIKNLPYLNAVIKETMRLNHVASMGLERMVTHDIIIKENIVVPKGTHVRCCLHVAQIHPDYWPEPLTFNPN
RWLKNADPEPCTDAFFPFSLGSRNCIGKDFSMNEMRLVLATLIKNYEIKPISEQMKASEEKHHFLTLTIESGSFKVRMKP
RAT*
>CYP5313A2 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
56% to CYP5313A3 Phycomyces blakesleeanus
fgeneshPB_pg.5__74
MNNLTKTVQLLSVKHYKSAFTNLVKSVVLLLCLQAISKKMYWAFFGPLSRIPGPFAEKFISGSELFFGTKPGQRFKKVIT
YHQKYGHVVRIGPKAISVSDKDIIKQVLVTEDFEKGPSYTRFQNGTSASMLDTTDKIFHKQRAISPAFSIKYIKSLEPLF
ETVTDDFIKRINREIAANKQDTDFATVDIWWLLRCLAFDIIGETSLGGTFNMLSNNDHIMLVSVGKLLRGIDF
(0)
VINHPWIAKLILLRK
VKKNPDLVNFVTNLIKERVKNKQRRDDIIQILINTQQAPKEEDRLSSDDIVVETTLFLVAGAETTSNTIGFS
MIELCRNKSALNRLRQEIDAIELEDGKQVFHQCQLRNLPYLNAVINETMRLNTIPSNGLERLVTRDIVIKGDIYVPSGTT
VRCYTGIAQTHPDYWSDPMEFKPERWLPNADPKPDMGAYNPFSAGSRNCVGKEFAMNEMRLAISTIIKHYDIEPISEEME
VARETRYFITLTLASSSFKIRMKHRNS
>CYP5313A3 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
56% to CYP5313A2 Phycomyces blakesleeanus
fgeneshPB_pg.14__210
MNFQREIRHGLATRLCQKPEVIQIGKITIGLFFLYHISNRFYYAFIGPLSKIPGPWIEKIFPELGGLFGKHHSQRFITLK
KYHEKYGHIVRIGPTEISISDKDMLKQILVTEDLSKGLGYKRFQNGGRANIFDTTDKGFHRQR
(0)
RRLVSPAFSIKYINSLEPLIESVTESLIARINRDIEGTKSSKGFGQIDIWRLFQLFSLDVVGETSFGGTFNALEDS
NHVVPVTISKLLRTLGFVS
(0)
VVNYPWIVKLLRIKK
TKKTPRLVAFATDIVLGRLEKGDRRNDILQIMIDTQKAAKEEDRLSTD
DIISEITMFLVAGTETISGTMGFVFIELCRHKNVWLKLRDEIDGIVLEEGKKFPCQSQLKDLPYLNAVINETMRLNSIVS
NGIDRIATRDIFMKGDVLVPEGTTVRCSPWIAQTHPDYWPEPLSFNPDRWLPGTDSKPNMEAYFPFSTGSRNCIGKTLAI
NEMRLVISALIKNFDLDDIPKEMMAANEKRYYITLTLESGSFKLLLKPRNACPQL*
>CYP5313A4 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
55% to CYP5313A2 Phycomyces blakesleeanus
fgeneshPB_pg.2__20
MDKLEKSSHNLIFYIQHNVPIIQLGKAAISLLAMYYMSNKIKCALFDPLNNIPGPFYRRFFPHFGNIGLKSGERFRLTEY
YHRKYGHVVRVGPDALSVSDKDIIKQILVIDDFEKGPAYSRLQNGGEASMLDLISKDLHRRRRRAISPAFSTKYIKSLEP
FFASSVESLIKKIDSEIEKTKGNEEFGTIDIWHITKCMALDVIGETAFGGTFNMIDNDDHIVPSTILKLMKILEFVISYP
WVTKIPFLKRNKRIPQLSNFVKNLIKSRLESNVKRDDILQILVDTMEAEDKRDRLTEYEIITETILFLVAGSETTSNTIG
FALIEMCRNPDSLEKLFIEIDGVDLDGGSNVFNQNQLKNLPYLNAIIKETMRLNTMPANGLERMVTRDIILKGDIFVPKG
TKVRCNISVAQVHPEYWSNPSAFKPERWLEDSNEKASPSAYFPFSAGSRNCIGKDFALNEMRLVLATLIKHYYIEPIPEQ
MVAAMEKRHYLTLTIASSSFKIRMKRRFS*
>CYP5313B1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
46% to CYP5313A2 Phycomyces blakesleeanus
estExt_fgeneshPB_pg.C_50177
MNYSSILNILKAPVWYMVSHLPEENTLGQFGKLAAVSLAVYYASDKLYCAFFGPLSKIPGPFIDKFFYEPEGVLFSHIGK
KSIRYLDYHEKYGPVIRVGPKTISISDKTMLKQVLVTEDLEKGPVYSILQNPGNESMFDARDKTYHKNN
(0)
RRMYSPAFSVKYINSIEPIMRSCTEIMAQKINSDIERTKGDGEYGTVDVWYLFQCLALDVIGESGFG
SNFNTVGDEDHPIPQCLKKNMN
(1)
GGLMTITPLATHMLEIVKDRVEGRTKRREDILQIMIDNERA
KNGDKPLDIMRIARSTVMFVIVGSETTSNTTGFAIIELCRSPDTMKRLRDEIDAIQLPEGETTFHQDQLKNLPYLNAVLN
ETLRLDSITASGLERIATQDSVLAGTVFVPKGTIVNCNILSAHRRADYWPEPLAFKPERWLPDYEHKPALDAYHPFSSGS
RNCIGKSYALNEMRHTIAMIIKNYEIKPIPEEMEASKNICGFLTLTVRSGSFKIQLKPRSA*
>CYP5314A1 Phycomyces blakesleeanus
(Zygomycete fungus, Mucoromycotina)
29% to CYP530A11 Fusarium oxysporum
estExt_fgeneshPB_pg.C_130264
MADYLSILSSEVQRFSTDHPQVAAAGALGAMALSLLYTGFGSKKASPDGAIPLPQPRGRMPVIGHLWSIVKAPHIKMAEY
SKELGPIYQMSFGGRDYIVLNSPEVIKGVLETNGSKNSDRVPSTVVLLMSDNGLMWAWGADNSYLRKSRRLFHNGFINKT
NWEKNFPELYNNQVGRILRKIRDHGTADEGYSLMDVCYLYTINVSMSVLFNRDYESCDDPDFLEMNAVAHDFSDLGVALQ
IECPKILEFAISPFMNNAKRLQNKFRSVFSKYIKELREKRAKGIIVKCLISDILDVQEKEQLTEPELDNFAAASMVGATD
TTALSLANLLVTLANYPEVQLKVQKELDTVVGIERHPTEQDLINLPYTKAVITECLRFCPPVWISLPHMSRERQVYNGYE
IPANTGILQNIYATNMSPELFDKPEEFNPDRYYKEELLKPNQRDHWSFGNGRRTCPGNIFAEKSLQYFTARILWAYTLTT
PLDKNGNPIPVPMTDIKDPISQPAHCNIRYVPRRANVGSFV*
>CYP6001A1 Emericella nidulans
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
fatty acid oxygenase (ppoA) gene AY502073
MGEDKETNILAGLGNTISQVENVVAASLRPLPTATGDGTYVAES
TQTGLAKDLSHVDLKDVRTLAEVVKSAATGEPVDDKQYIMERVIQLAAGLPSTSRNAA
ELTKSFLNMLWNDLEHPPVSYLGADSMHRKADGSGNNRFWPQLGAAGSAYARSVRPKT
MQSPSLPDPETIFDCLLRRKEYREHPNKISSVLFYLASIIIHDLFQTDPKDNSVSKTS
SYLDLSPLYGNNQDEQNLVRTFKDGKLKPDCFATKRVLGFPPGVGVLLIMFNRFHNYV
VDQLAAINECGRFTKPDESNVDEYAKYDNNLFQTGRLVTCGLYANIILKDYVRTILNI
NRTDSTWSLDPRMEMKDGLLGEAAAMATGNQVSAEFNVVYRWHACISKRDEKWTEDFH
REIMPGVDPSTLSMQDFVAGLGRWQAGLPQEPLERPFSGLQRKPDGAFNDDDLVNLFE
KSVEDCAGAFGASHVPAIFKSVEALGIMQARRWNLGTLNEFRQYFNLAPHKTFEDINS
DPYIADQLKRLYDHPDLVEIYPGVVVEEAKDSMVPGSGLCTNFTISRAILSDAVALVR
GDRFYTVDYTPKHLTNWAYNEIQPNNAVDQGQVFYKLVLRAFPNHFDGNSIYAHFPLV
VPSENEKILKSLGVAEKYSWEKPSRISHPIFISSHAACMSILENQETFKVTWGRKIEF
LMQRDKHQYGKDFMLSGDRPPNAASRKMMGSALYRDEWEAEVKNFYEQTTLKLLHKNS
YKLAGVNQVDIVRDVANLAQVHFCSSVFSLPLKTDSNPRGIFAESELYKIMAAVFTAI
FYDADIGKSFELNQAARTVTQQLGQLTMANVEIIAKTGLIANLVNRLHRRDVLSEYGI
HMIQRLLDSGLPATEIVWTHILPTAGGMVANQAQLFSQCLDYYLSEEGSGHLPEINRL
AKENTPEADELLTRYFMEGARLRSSVALPRVAAQPTVVEDNGEKLTIKAGQVVMCNLV
SACMDPTAFPDPEKVKLDRDMNLYAHFGFGPHKCLGLDLCKTGLSTMLKVLGRLDNLR
RAPGAQGQLKKLSGPGGIAKYMNEDQSGFTPFPSTMKIQWDGELPQLKEDF
>CYP6001A1 Aspergillus oryzae
Supercontig 6: 3114893-3118488
(-) strand
99% only 1 aa diff to CYP6001A1 Aspergillus flavus
MAESESGGVINGLGKTVSQLEKVVSASLRPLPTETGDGSYVKES
NSTGIVRDLGRMDLSDVKTIVELTKNAATGEPLNDKHYIMERLIQ (0)
LTSALPSNSRVGKELTNAFLNQLWKDLEHPPVS (2)
YLGREYSYREADGSGN (0)
NVLWPHIGAAGSHYARSVRPKTLQSPALPDPETLFDSLLVRKDFKEHPNK
ISSILFYIASIIIH (1)
DLFQTDRNDATISLTS
SYLDLSPLYGNNQDEQNLVRTFKDGKLKPDCFSTKRVLGFPPGIGVILIMFNRFHNYV
VEQLASINEGGRFTKPDESDTKAYARYDNDLFQTGRLVTCGLYVNIILKDYVRTILNV
NRTDSLWSLDPRAEMKDGLLGEAAAQATGNQVSAEFNLVYRWHSCISQRDEKWTEDLY
KDMFPGRDPSSVSLQEFVRGLGKWEADLPEQPEDRPFAGLQRKPDGSFDDDSLVKIFE
DSVEDCAGAFGASNVPTIFKSIEALGIKQARSWNLATLNEFRNYFNLTPYKTFEEINP
DPVISDQLKRLYDHPDHVEIYPGVIVEDTKEAVVPGSGLCTNFTISRAILSDAVALVR
GDRFYTVDFTPRHLTNWAFSEIEPKDSVDQGQVFYKLVLRAFPNHFKGNSIYAHFPLV
IPSENKKILTKLGFAEKYSWDKPGLTPPPEFINSHSACMSILSDQETFKVTWGSKIEF
LMHRGKQPFGRDFMLSGDRPPNSASRKMMGAALYRKRWENEVRSFYEDITLKLLHRNS
YKIAGINQVDIVRDVANPAQVNFCANVFSLPLKTESNPRGIFTESELYQIMAVVFTSI
FYDADPANSFELNQAAREVTQQLGQLAMANVELVNNTGFIANLVSSLHRHDVLSEYGV
HMIQRLLGSGLPAEEIVWTHILPTAGGMVANQAQLFSQCLDYYLSEEGSVHLPDIKRL
AKVDTPETDELLLRY (2)
FMEGARLRSSVGLPRMVTKPTVIEDNGKKLNLKAGQHILCNL (0)
VSASMDPTSFPEPEKVRLDRDMDLYAHFGFGPHQCLGIGLCKLALTTMLKVIGRLDNLR
RAPGPQGQLKKLSGPGGIAKYMNPNQSGFSPFPTSMKIQWDGELPQVER*
>CYP6001A1 Aspergillus flavus NRRL3357
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
EQ963473 fatty acid oxygenase PpoA, putative
Name revised from CYP6001A2
AFL2G_01904 Note: this gene model is fused to
a ubiquitin-protein ligase.
Probably this is an error.
MAESESGGVINGLGKTVSQLEKVVSASLRPLPTETGDGSYVKES
NSTGIVRDLGRMDLSDVKTIVELTKNAATGEPLNDKHYIMERLIQLTSALPSNSRVGK
ELTNAFLNQLWKDLEHPPVSYLGREYSYREADGSGNNVLWPHIGAAGSHYARSVRPKT
LQSPALPDPETLFDSLLVRKDFKEHPNKISSILFYIASIIIHDLFQTDRNDATISLTS
SYLDLSPLYGNNQDEQNFVRTFKDGKLKPDCFSTKRVLGFPPGIGVILIMFNRFHNYV
VEQLASINEGGRFTKPDESDTKAYARYDNDLFQTGRLVTCGLYVNIILKDYVRTILNV
NRTDSLWSLDPRAEMKDGLLGEAAAQATGNQVSAEFNLVYRWHSCISQRDEKWTEDLY
KDMFPGRDPSSVSLQEFVRGLGKWEADLPEQPEDRPFAGLQRKPDGSFDDDSLVKIFE
DSVEDCAGAFGASNVPTIFKSIEALGIKQARSWNLATLNEFRNYFNLTPYKTFEEINP
DPVISDQLKRLYDHPDHVEIYPGVIVEDTKEAVVPGSGLCTNFTISRAILSDAVALVR
GDRFYTVDFTPRHLTNWAFSEIEPKDSVDQGQVFYKLVLRAFPNHFKGNSIYAHFPLV
IPSENKKILTKLGFAEKYSWDKPGLTPPPEFINSHSACMSILSDQETFKVTWGSKIEF
LMHRGKQPFGRDFMLSGDRPPNSASRKMMGAALYRKRWENEVRSFYEDITLKLLHRNS
YKIAGINQVDIVRDVANPAQVNFCANVFSLPLKTESNPRGIFTESELYQIMAVVFTSI
FYDADPANSFELNQAAREVTQQLGQLAMANVELVNNTGFIANLVSSLHRHDVLSEYGV
HMIQRLLGSGLPAEEIVWTHILPTAGGMVANQAQLFSQCLDYYLSEEGSVHLPDIKRL
AKVDTPETDELLLRYFMEGARLRSSVGLPRMVTKPTVIEDNGKKLNLKAGQHILCNLV
SASMDPTSFPEPEKVRLDRDMDLYAHFGFGPHQCLGIGLCKLALTTMLKVIGRLDNLR
RAPGPQGQLKKLSGPGGIAKYMNPNQSGFSPFPTSMKIQWDGELPQVER
>CYP6001A1 Aspergillus clavatus NRRL 1
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001271947 fatty acid oxygenase PpoA,
putative
ACLA_049940
Name revised from 6001A3
MSGKREESTNGGIGKTIAQIEKVVTASLRPLPSKTGDGTYVTEA
VKTGLLKDLSHVDLGDLKTLLEVSKSALTGEAVDDKKYIMERVVQLAAGLPSTSQIGK
DMTNTFLTTLWNDLEHPPISYLGRDAMYRKADGSGNNILWPHIGAAGTPYARSVRPKT
MQSPNLPDPETLFDCLLARKEYKEHPNKISSVLFYIASIIIHDIFQTDRKDPTVSLTS
SYLDLSPLYGNNQDEQNLVRTFKDGKLKPDCFSTKRVLGFPPGVGVLLIMFNRFHNHV
VENLALINEGGRFTKPQESDAQAYAKYDNDLFQTGRLITCGLYVNIILKDYVRTILNI
NRTDSIWSLDPRADMKDGLLGEAAAQATGNQVSAEFNLVYRWHSCISKRDQKWTEDMY
QEVFPGQDPSKLPLQDFMRGLGRWEAKLPGEPQERPFAGLQRKADGSYDDDDLVKIFG
DSVEDCAGAFGVLHVPTVFRSIEALGIQQARSWNLATLNEFRNYFNLAPYKTFEEINP
DPYVADQLRRLYDHPDRVEIYPGIIVEDTKESMAPGSGLCTNFTISRAILSDAVALVR
GDRFHTVDFTPKHLTNWAYNEIQPQESVDQTHVLYKLVFRAFPNHFKGDSIYAHFPLV
IPSENKKILTKLGTADKYSWDRPSFTHPPQFINSHSACMSILADQETFKVSWGKKIEF
LMRHNDQPHGRDFMLSGDKPPNAESRQMMGKALYRNKWETEVKDFYEEITLKLLHRNS
YKLAGTNQVDIVRDVANLAQVYFCASVFSLPLKTESNPRGVFTESELYQIMAVVFTSI
FYDADVCKSFELNQGARAVTQQLGQLTMANVELIEKTGFIANLVNSLHRHDALTEYGV
HMIQRLLDTGTPAAEIVWTHVLPTAGGMVANQAQLFSQCLDYYLSDEGSIHLPEINRL
AKQDTPEADDLLLRYFMEGARLRSSVALPRVVAQPTVVEDNGQKVILKEGQHILCNLV
SASMDPASFPEPDKVKLDRDMNLYAHFGFGPHQCLGIGLCKLALTTMLKVVGRLDNLR
RAPGGQGRLKKLSGPGGIAMYMTPDQSGFFPFPTTMKIQWDGDLPPLKTE
>CYP6001A1 Aspergillus fumigatus Af293
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XP_751750.1 fatty acid oxygenase PpoA
SAME AS EAL89712.1 fatty acid oxygenase PpoA
Name revised from CYP6001A5
MSEKQTGSANGGLGKTLAQLEQVVSASLRPLPSQTGDGTYVTEQVKTGILKDLSHVDLGDLKTLVDVSKS
ALTGEALDDRKYIMERVIQLSAGLPSTSQIGKELTNTFLTTLWNDLEHPPISYLGRDAMYRRADGSGNNV
LWPHIGAAGTPYARSVQPKTVQSPNLPDPETLFDCLLARKEYKEHPNKISSVLFYIASIIIHDLFETDRK
DPAISLTSSYLDLSPLYGNNQQEQDLIRTFKDGKLKPDCFSTKRVLGFPPDVGVVLIMFNRFHNYVVEKL
AMINEGGRFTKPQESDTAAYAKYDNDLFQTGRLVTCGLYVNIILKDYVRTILNINRTDSIWSLDPRSEMK
DGLLGRAAAQATGNQVAAEFNLVYRWHSCISQRDQKWTEDMYQELFPGQDPSKISLQDFLRGLGRWEAKL
PGEPRERPFAGLQRKADGSYDDNDLVKIFEESVEDCAGAFGALHVPTVFRSIEALGIQQARSWNLATLNE
FRKYFNLAPYKTFEEINSDPYVADQLKRLYDHPDRVEIYPGIIVEDAKESMAPGSGLCTNFTISRAILSD
AVALVRGDRFHTVDFTPKHLTNWAYNEIQPQDSVDQTHVFYKLVLRAFPNHFRGDSIYAHFPLVVPSENK
KILTKLGTADKYSWDRPNYTPPPQFINSHSACMSILSDQETFKVTWGSKIEFLMRHNNQPYGRDFMLSGD
RTPNAMSRQMMGKALYRDKWETEVKRFYENITLKLLHRYSYKLAGVNQVDVVRDIANLAQVHFCASVFSL
PLKTESNPRGIFTESELYQIMAVVFTSIFYDADIGKSFELNQAARAVTQQLGQLTLANVELIAKTGFIAN
LVNSLHRHDVLSEYGVHMIQRLLDSGMPAPEIVWTHVLPTAGGMVANQAQLFSQSLDYYLSEEGSVHLPE
INRLAKEDTTEADDLLLRYFMEGARIRSSVALPRVVAQPTVVEDNGQKITLKQGQHIICNLVSASMDPVT
FPEPDKVKLDRDMNLYAHFGFGPHQCLGLGLCKTALTTMLKVIGRLDNLRRAPGGQGKLKKLSGPGGIAM
YMTPDQTAFFPFPTTMKIQWDGDLPEVKE
>CYP6001A1 Neosartorya
fischeri NRRL 181
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001266940, same seq as DS027685Neosartorya
fischeri NRRL 181 XP_001266941.1
96% to CYP6001A1 Aspergillus
fumigatus = ortholog
NFIA_105320
Name revised from 6001A4
MSEKQTGSANG GLGKTLAQLEQVVSASLRPLPSQTGDGTYVTEQ
VKTGILKDLPHVDLGDLKTLVDVSKSALTGEALDDRKYIMERVV
QLAAGLPSTSQIGKELTNTFLTTLWNDLEHPPISY
LGRDAMYRRADGSGN
NVLWPHIGAAGTPYARSVRPKT
TQSPNLPDPETLFDCLLARKEYKEHPNKISSVLFYIASIIIHDLFQTDRKDPAISLTS
SYLDLSPLYGNNQEEQNRVRTFKDGKLKPDCFSTKRVLGFPPGVGVVLMMFNRFHNYV
VEKLAMINEGGRFTKPQESDTAAYAKYDNDLFQTGRLVTCGLYVNIILKDYVRTILNI
NRTNSIWSLDPRSEMKDGLLGSAAARATGNQVAAEFNLVYRWHSCISQRDQKWTEDMY
QELFPGQDPSNISLQDFLRGLGRWEAKLPEEPQERPFAGLQRKADGSYDDDDLVKIFE
ESVEDCAGAFGALHVPTVFRSIEALGIQQARSWNLATLNEFRKYFNLAPYKTFEEINP
DPHVADQLKRLYDHPDRVEIYPGIIVEDAKESMAPGSGLCTNFTISRAILSDAVALVR
GDRFHTVDFTPKHLTNWAYSEIQPQDSVDQTHVFYKLVLRAFPNHFRGDSIYAHFPLV
VPSENKKILTELGTADKYSWDRPNYTPPPQFINSHSACMSILSDQETFKVTWGSKIEF
LMRHNNQPYGRDFMLSGDRTPNAMSRQMMGKALYRDKWETEVKKFYENITLKLLHRYS
YKLAGVNQVDIVRDIANLAQVHFCASVFSLPLKTESNPRGIFTESELYQIMAVVFTAI
FYDADVGKSFELNQGARGVTQQLGQLTLANVELIEKTGFIASLVNSLHRHDVLSEYGV
HMIQRLLDSGMPAPEIVWTHVLPTAGGMVANQAQLFSQSLDYYLSEEGSVHLPEINRL
AKEDTPEADDLLLRYFMEGARIRSSVALPRVVAKPTVVEDNGQKITLKQGQHIICNLV
SASMDPVSFPEPDKVKLDRDMNLYAHFGFGPHQCLGLGLCKTALTTMLKVIGRLDNLR
RAPGGQGHLKKLSGPGGIAMYMTADQTGFFPFPTTMKIQWDGDLPELKE
>CYP6001A1 Aspergillus terreus
79% to CYP6001A1 Aspergillus oryzae
Supercontig 5: 1242713-1246265 (-) strand
ATEG_03992.1
MQGIGKAISQLEKVATASLRPLPTETGDGSYVAESTATGLVQDLPHVDLGDLKT
LLDVTKNAATGEPIDDKGYVMERLIQ (0)
LASGLPSTSRNAKQLTSAFLNQLWNDLDHPPVS (2)
TVGGEYSHRSADGSGN (0)
NILWPGIGAAGSHYARSVQPKTMQSPSLPDPEALFDSLLARKDFKEHPNKISSVLFYIASIIIH
(1)
DLFQTDHRDSSINRTSSYLDLSPLYGNNQDEQYLMRTFK
DGKLKPDCFSSKRILGFPPGVGVLLIMFNRFHNYVVEQLAAVNEGGRFTKPSESNDKEYA
KYDNNLFQTGRLVTCGLYINIILKDYVRTILNINRTNSTWSLDPRMDMKDGLLGDAAPLA
TGNQVSAEFNLIYRWHSCISQRDEKWTTDLYNDIFSDKGQEDIPLNEFMMGVGKWEAGLP
QQPAERPFAGLKRKPNGLFDDDDLVTIFKESVEDCAGAFGASHVPTIFKSIESLGIKQAR
AWNLATLNELRQYFGLTPHKTFEDINSDPYISEQLRRLYDHPDQVEIYPGVIVEETKESM
LPGSGLCTNFTISRAILSDAVALVRGDRFYTVDYTPKQLTNWAFTEIQPKDSVDQGHMFH
KLVYRAFPNYFKGNSVYAHFPMVVPSENQKILTALGSAEKYSWDKPGFIHPPQFINSHST
CVSILADQETFKVSWGDKIEFLMSNHDKIYGKDFMLSGDRLPNAESRKMMGAALYTDQWE
EEVKKFYEKITLKLLKKHSYKIAGVNQVDIVRDVANLAQVNFCANVFSLPLKTEASPRGI
FTESELYMIMAAVFAAIFYDADPANSFALNQAAREVTQQLGQVTMANVELIHKTGFISNL
VNGLQRHDVLSNYGIHMIQRLLASGLPASEIVWTHLLPTAGGMVANQGQLFSQCLDYYLS
EEGSVHLPEINRLAKENTPEADELLLRY (2)
FMEGARLRSSVGLPRVVAKPTVIDDNGTKLTLKEGQHILCNL (0)
VAASHDPVSFPEPEKVRLDRDMDLYVHFGSGPHKCLGFGLCKLGLTTMLKVVGGLDNLRR
APGPQGQLKRLAGPGGISKYMTADQSGFFPFPTTMKIQWDGDLPEPASD*
>CYP6001A1 Aspergillus niger
Supercontig 17: 397517-401111 (+) strand
76% to CYP6001A1 Aspergillus oryzae
MSGANNHSIVNGIGSTISQVEKAISASLRPLPTATGNGTYITEPDQTGIVKDL
SHVDFTDIKALLEVVKDAVTGQPVDDRHYIMERVIQ (0)
LAAGLPSTSKNGKDLTNAFLKQLWNDLEHPPIS (2)
YLGRDSSYRKADGSGN (0)
NFLWPHIGAAGSHYARSVRPTTVQSPSLPDPS
TLFASLLERKEYKEHPNKISSVLFYLASVIIH (1)
DLFQTDRSDFTLNKTSSYLDLSPLYGNNQDEQDLVRTFK
DGKLKPDCFSSKRVLGFPPGVGVLLLMFNRFHNYVVENLATINEGGRFTKPDESDVDAST
KYDNDLFQTGRLVTCGLYINIILKDYVRTILNINRTDSLWSLDPRADIQDSLLGSAPAEA
TGNQVSAEFNLVYRWHACISQRDEKWTQDLYKDLFPGKDPNNVSLQEFIRGVAKWEASLP
EQPPDRPFAGLQRNADGAFDDGDLANMFADGVEDCAGAFGAGNIPSVFRNIEALGILQAR
SWNLATLNEFRKFFDLAPYKTFEEINPDPYIAAQLKNLYDEPDLVEMYPGVIVEATKDAI
VPGSGLCTNFTISRAILSDAVSLVRGDRFYTVDYTPKHLTNWAYNEIQPQDSVDQGQVFY
KLVLRAFPSHFKGDSVYAHFPLVIPSENKKILEKLSVAQDYSWGRPSYTPSPQFVSSNAA
CISVLNDQEAFKVTWGSKIEFLMRHNNHPYGRDFMLSGDKPPNAASRRMMGSALYRDKWE
SEVKRFYEDITIKLLRQHSYQLGGVNQVDIVRDVANYAQVHFCANVFSLPLKTESNPRGI
FAESELYEILALVFASIFYDADVGTSFQLNQTARDVTQQLGELTMANVDFVNKAGFIANL
VSSLHRHDVLSEYGEHMIQRLLHSNVPPAEIVWTHLLPTAGGMVANQAQLFSQCLDYYLS
DEGSIHLPDIKRLAKENTSEADALLLRY (2)
FMEGARLRSSVGLPRLVAKPTVVDDGGSKYTLKPGQSVLCNL (0)
VSASMDPRSFPEPEKVKLDRDMSLYAHFGFGPHQCLGMGICKLALTTMLRVVGRL
DNLRRAPGSQGQLKKIAGPGGISMYMTADQSSYWPFPSTMKIQWDGDLPSLATN*
>CYP6001A2 Coccidioides immitis RS
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001247707.1 linoleate diol synthase
(CIMG_01479)
Name revised from CYP6001A6
MVLDSSSRRGVLDDLAKYFPHFGGIANGSLWPITPDSGHHSPSQ
GPTGGLLQDLGSLDVKDVGTVLELIKNTASGAPVEDKRYIMERVIQLASSLPSTSHNR
TTITNTLLAQLWNDLSHPPVSYLGRDVIYRQADGSYNNIYWPQIGKAGSNYARSVQPK
SIQPASRPDPGLLFDGLLARQQFKEHPNKLSSVLFYLAALIIHDLFRTDPTDSSRNMT
SSYLDLSPLYGCNQEEQNQVRTFKDGKLRPDCFSERRVFGFPPGVGVLLIMFNRFHNY
VVQNLAAINENNRFRKPDESDADACAKYDNDLFQTGRLITCGLYINIILKDYVRNILN
INQTDSDWSLDPRSDVKELLSHKPVQEAGGNMVAAEFNLVYRWHSCLSDRDDRWMQEI
FEKALDGKDLDTIGMPEFLGKIRKLQSSIPDDPMLRPFANLERQSNGSYDDNDLVKIL
TESIEDCAGSFGARHVPKVLRSVEILGILQARSWNLSSLNEFRKYFNLAPHTSFEDIN
SDPEVVEQLRHFYGHPDNVELYPGIVVEEGKPRIVPGSGLCASYTISRTVLSDAVALV
RGDRFYTVDYTPQNLTNWGYNEANYDMTVNNGHIFHKLILRAFPRHFKPDSVYAHFPF
VIPSENKKILSDLGLAEKYSWERPGAVPHPTVILSHGACNAILHNKEDFKITWGEKVK
HIMARNSIPYGADFMLSGDEQVHEDSRQMMKKALYIEDWCGQVRAFYERITLELLHSK
SHRISGVSQVDIVRDVANLAAIHFSSNIFLLPLKTEGLPHGVFTDTELYRSMALILNY
IFYDVDPTQSFKLRERSRSESQKLGELVMLNVQAISKTGFIGSIIDKLHGNEALANYG
VHMIRRLLATQMPIDELVWTHILPTAGGMVANQAQLFSQCLDFYLSEQGSRHWPEIRR
LAGLNTKEADDLLLRYFLEGARIRSTVALYRDVSKDCKVQDHGKEVNLHAGQRIICNL
MSACKDPEVFPEPDEVDLTRDLDSYIHLGVGPHECLGKGMVQIGLTTMLKVVGRLDNL
RRAPGPQGQLHSIPGPGGIPLYMSEDESEVSPFPATMKVLWDGELPPLPQ
>CYP6001A3 Pyrenophora tritici-repentis
Pt-1C-BFP
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001936500.1 linoleate diol synthase
Name revised from CYP6001A7
MSATEEAKAAWDSHVDTRTGIEPPKAADASEISTLRSAIGAPFR
AAAGLIGAVTAPVPDQTGDGSKIPPEEKASLYKKIEGGLRDMSHLGIENIGSLLEIQK
EKMLGSYTDDKTYLMEGLIRTAAALPDGSKTRDAVTANFLSQLWNDLQHPPQSYLGTK
YQYRSADGSNNSLVNPQVGAAGTPYARTVKPITMQTPARPDPGVIFDSIMTRKHAELH
PNRISSMLFYLASIIIHDCFRTSHEDYSISMTSSYLDLSPLYGSNQAEQDMMRTGKDG
KIKPDCFSESRLLFFPPGVGALLIMFGRFHNYTVENLAEINEQGRFTKPSAEVPKSTG
DVEVDKKTQEKYDAAWKKYDNDLFQTGRLITCGLYVNTILIDYVRTILDLNRTDSNWQ
LNPRSEVEGLPMGIGNQVSAEFNLVYRWHSTVSDRDEKWTQEMWEGIFGEDCDPKSIG
KHEFLGRLNEVYKKTDRDPSKREFAGLKRNEDGTFPDQGLVDILTSSIEDCANSFGPN
RVPSVFRAIEVLGIEQARSWNLGSLNEFRKHFKLEPHKTFEDITSDKYVQEQLKHLYD
TPDKVEIYPGMVVEDAKKPMAPGSGLCTNYTISRAVLSDAVALVRGDRFYTQDYNPRT
LTNWGYNLADSDIGIDNGCVFYKLFLRALPQHFKYNSVYAHYPLTVPSAMQIALTDLK
KDHLYDFSKPVATPHPHIVKEYKLATQIMKDQTNFKVVWGRAMEYIMGPTAADFMLAG
DGPKNTASRQMMSKALYISDWDKEVRTYYTLKMQQLLQEKAAKIADFNQVDIIRDVGN
LAHVHFCSELFMLPLKTDDRPYGIFTEAELYLIMSSVFALIFFDADPASSFPLHVKAR
KATQILGTIVEKNVAAIAKSGILSSIIQTIWPHESVLKSYGVHMIKRLLETGMEPKQL
VWGHILGTAGGMVSNQGQLFAQTLEYYILGAGQKHWPAIQALAAQDGEEAFETLMHYT
MEAGRLNGETGVIRAVAHPTPLTTADGTTTTLSPGSTVFVKLRSASHDPAVFPNPDEV
DITRPLDSYIHLGYGPHQCLGLPMTRVALTTMLKEVAKLKNLRPAKGPQGKIHKVEKR
MEKVAEEEYVYHAYLTENWDMYFPFPCALKLCWDD
>CYP6001A4
Mycosphaerella graminicola MgPOSS13100
55% to CYP6001A3 Pyrenophora tritici-repentis
MRKDTRKSMEQLGTLLKAIRAPLPTQTGDGSALPQPKKDTFSKDVREILRDIPRQDIDDIEGLIKVFKSTAMGENLDDKEYLMESMIAVATKLPESFLQDRLTTTLVTTLWNDLEHPPNVILGE
EYEFRQPDGSNNNFKYPNVGKAGMPYARTVNPKSKQGGVLPDPGVLFDTVMARKHEAGEKHPNRISSMLFYLASIIIHDIFRTDHLDARISNTSSYLDLSPLYGSNWKEQKTMRTFQNGKIK
PDCFAETRLLSFPPGCGALLIMFNRYHNYVVEQLALINEDGRFTENPRQVTVDRYGETGLNKRDDDLFQTARLIVCGLYINIILIDYVRTILNLNRTDDNWQLDPRVDIPGGIPVATGNQCSAE
FNLVYRWHSAVSERDDLWTQQLFKELPLPDGLTAEDAAKPENMKKFLMTLAHMQHDTESKDPTERDFPALKSEKMDRIPEGPFKGNYKDDDLAALLTSSIEDCANAMGPQQVPAVMKAIE
ILGIQQARTWRCATLNEFREHFHLKPHKTFEDITTNKEVSEALKHLYNTPDDVELYPGLVVEDDKQAKLPGSGLCPSYTTSRGVLSDAVALVRGDRFYTTAYTPASLTNWGFQEASSDLSIDN
GCVFYKLFLRALPNSYDPGSVYVHYPMTIPDEMKTILQGLEKDHMYNFDKPKASHHPVTLFSHAAGMQVTENQEDFHVTWGPAMIFLMGPEAKNFMLAGDGPENAKSRAMMEKTMYQGI
PSGNEKWLTAVRDFYEMKTTELLKQKSYKLAGVNNVDIIRDIGNLAHVHFCAELFSIPLKTEKFPLGIFTEQQLYLIMAAVFTCVFFDLDPPKSFPLRQKARAATQSLGNIMKAQVQSVKTFG
KLAESLIDVVKPNDGPLGDYGVHMIAQLCKQDVDVDDLVWGNIMGTAGGMVANQGQLLGQALDYFFTTGKDHLPEINRLAKLDTPEADDTLMHYLMEGARLNGETAIFRTVTKDTTVVD
NTPLLGEQVHHLKKGDTVFVNLKSASRDAAAYPNPDALDLTRDLNSYITLGHGVHQCMGLPMTRVALTTMLKVIGRLDNLRPAPVSVGTQSVGHSVKKVMKEFVPGDKHVLPEEWHYHL
YLTEDWDQYFPFPTSKFEMV
>CYP6001A5 Mycosphaerella fijiensis
70% to CYP6001A4 Mycosphaerella graminicola
estExt_Genewise1.C_11811
MSHSAKSNCVKMPLDPELSTLDRYRQSVGQSLTSLKTLLNAVRAPLPKDTGDGTYLPQADNETVLGEINDVIRDLARQDI
KDIAGLVETVKGAALDKPLDDRKYLMETMVRVASKLPTDDLQKKITETLIITLWNDLEHPPQTLLSDEFQFRQPDGSNNS
YKYPDIGKAGMPYARTVAPKTKQAGVLPDPGILFDSVLARKSPKGELHPNRISSMLFYLASIIIHDIFRTDHRDFTKSNT
SSYLDLAPLYGSNWEEQKKMRTFKNGMIKPDCFSETRLLGLPPGVGAILICFNRYHNYVVQQLAAINEDGRFTEDAEKPA
MVERYTNKEGKKDTINKRDDDLFQTARLITCGLYINIILIDYVRTILNLNRTDSNWQLNPRVEVQDGPPMGTGNQCSAEF
NLVYRWHSAISERDDYWTQELFKEMFPGVEPSKVAEPQNVGMFLGKLAEDQMKIQKLDPTERPFPALKAEQEKMPRKKDG
PFKGNYDDDDLADLLTSSIEDCANAMGPQQVPTIMKAIETLGINQARTWRCATLNEMRKHFKLKPHEKFSDITENEEVAT
ALKHLYDSPDQVELYPGLVVEDAKDPVLPGSGLCPSYTVSRGVLSDAVALVRGDRFYTSAYTPALLTNWGYQEAHYDLAI
DNGCVFYKLFLRALPNSFDPMSVYVHYPLTIPSETRTILKGLKKDHLYNFDRPQESHHPVVLFSAEAAKKVTEDQETFHV
TWGPAMEFLMGPKAKNFMLAGDGPENAASRKIMEKPMYQGASSRSIPQGNEKWLRAVRDFYELKTTELLKQKSYKLAGMR
YVDIIRDVSNMAHVAFGAELFSIPLKTEDFPHGIFTEQQLYLIMAAVFICVFFDLDPPKSFPLRVKAREACQTLGKIMAL
QVESVKRFGKLSETLIDAVMPNEGPLKEYGVHMIAQLCKANPDLSVDDLVWGNIMGTAGGMIPNQGQLFGQALDYFFTNE
GHKYWSDIQKLAKQDTLEADDKLMHYLMEAARLSGETGAFRYATKDVTIVDDTGLENLPIGDKGKITHHIKQGDIVMVNF
KAASRDARLFPNPDQLDLNRPLDSYLMLGHGAHQCLGLPMTRVALTTMLKVIARLDGLEPMPVSVGKQSGPHCVKKVVKE
FIPGDRAYLPESWHYHLYLTEDWDQYFPFPTSLKLRFKGEVPNVKAA*
>CYP6001C1 Emericella nidulans, Aspergillus
nidulans
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
FATTY ACID OXYGENASE PpoC (Afu3g12120)
AY613780.1
1 MLRRFSTFRK SKGDKTEKAD RDSKANGSNA NSAAAASNSS KRQSKVPPPR RPSSDSGSSA
61 ESEDVPAVFE KYAQVLHASS RPIPHQGGEA AYLEKEHPSG LFNDLKSLGF
KDFASLKDVI
121 KTKINGELTD DKTMIMERII QIVSSLPSNS
KMRVDLTNMF LDELWGSLPH PPLSYMGNDY
181 QYRSADGSNN NPTLPWLGAA NTAYARSIEP
LTVQPGGLPD AGLVFDTLFA RQKFTPHPNK
241 VSSLFFDWAS LIIHDIFQTD YRDYNKNKTS
AYLDLAILYG DVQEEQDLVR THKDGKLKPD
301 SFSEPRLQAF PAACCVLLVM LNRFHNYVVE ELAAINENGR
FTKPSPDLPE EQAKKAWAKY
361 DEDLFQTGRL ITCGLFINIT LYDYLRTIVN
LNRVNSTWCL DPRAQMEGSA TPAGLGNQCS
421 VEFNLAYRWH SAISANDEKW TEKVYEELIG
KPGSEISTQE LLMGLGKYGA SLPKDPSQRT
481 FAGLKRQEDG TFKDEELVNI LTSAIEDVAG
SFGARNVPKV LKAVEVLGIE QGRKWNVGSL
541 NEFRKFFGLK NYETFEEINS DPEVAESLRA
LYGHPDYVEL YPGIVSEEAK EPMIPGVGIA
601 PTYTISRAVL SDAVALVRGD RHYTVDYNPR
NLTNWGYNEV RYDLNINQGC VFYKLATRAF
661 PNWFKPDSIY AHYPMTIPSE NKVIMKNLGR
EADYSWDRPQ YQAPRASLTS YSNVKLILDQ
721 QKDFRVVWGD CTPLHSGKGG EDFWSKTLSD
PQFKKSIKEF YEKTTLELFA DKSVNLAGRK
781 QIDIVKDVGN IVPARFASKL LSLPLRSKEN
SKGVFTDHEI FMALAVIYNA IFFDVDTTKS
841 FPLRKAADAV SKELGKHVES HVKSVSSPGF
LSRVIDNFRD DHNALKDLGD QLIKRLAEGG
901 LSVSDITYGQ ILPTAVELVH GQAQMFTRVV
EYYLNEGKQH LPELSLLAKQ DSAETDAKLT
961 RYALEAIRLN AGSGAYRKAE TNFYFKEGDA DINLKPGDEI
FISSTQANRD PTAFPDPDEV
1021 RLDRPDESYL NYGIGSQIGL GKDATLTAVT
AMVRAAFSLE GLRPAPGVQG VLKKVVRPEG
1081 YTLYMREDHG AFSPFPTTFR VHFDGEVVTP KKQIDSA
>CYP6001C2 Aspergillus fumigatus Af293
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XP_754409.1 fatty acid oxygenase PpoC
SAME as EAL92371.1
95% to CYP6001C2 Neosartorya fischeri = ortholog
MLRRFSSTFKKKGDRESKQNGTASSSSAAVANTNNNDNKRHSKISAARKSSSDDDRNEK
KGNSVSPFEKYASVLHASRSPIPNQTGDGAYLEHEHTTSLLQDARHLGFKDFKTLKEVIESKLPGGQLIDDKTMLMERIIQ
(0)
LVSRLPHNSKHREELTNAFLTELWDSLPHPPLS (2)
YMGNDYAYRSADGSNNNPTLPR
LGAANTLYARTIPPLIIQPGGLPDPGLVFDTLFARQTFKPHPNKVSSVFFYWASLIIH (1)
DIFQTDYKNPNMNKTSGYLDLSILYGDVQEEQNLIRTFKDGKLKPDSFSEPRL
QAFPATCCVLMVMLNR (2)
FHNYAVEQLAAINENGRFTKPADNLSEEEAKKAWAKYDEDLFQTGRL
(2)
ITCGLYINITLYDYLRTIVNLNRTNSTWCL
DPRAQMEGSHTAPSGLGNQCSVEFNLAYRWHSATSATDEKWTEDV
YERLMGKPASEVSMTELLMGLGKYQAELPKDPSKRTFADLERQADGRFKDEDLVNLLVNAVEDVA
GSFGA
RNVPKVLKNVEILGIIQSRKWNVGSLNEFRKFFGLKPYETFEEINSDPDVAESLRSLYDHPDFVELYPGI
VAEEAKQPMVPGVGIAPTYTISRAVLSDAVALVRGDRFYTIDYNPRNLTNWGYSEVRYDLSINQGCIFYK
LATRAFPNWFKPDSIYAHYPMTIPSENRKIMKDLGREIHYSWDRPQYTPPRVDLVSYSNAKLVAEQQNQF
RAAWGDTVEFVFGKASKEFKLYQDSAFIQKHADVMSKLLNKEEWHRSVKEFYEDITAKLLEDKTRRFGGI
NQVDI
TNDVGNLTPVIFAANVFSLPLKSKENPRGIYTEHEMFKVLAALYNCLYFDIDKTKSYPLHHASQA
VGEPLGKALEANVKALGGSSLLSGIFRSFRENKNALKEYGVHLTKQLLENGLGAHEIAWAQFLPTVIAMV
PAQAQA
FTQIVDFYLSKEGSKHLPAIQRLAKQDTKKSDEQLLHYCLEAVRLNDMSGLYRQSETTLAVTDE
AVEVTIQPGDKVFVSFAKANRDASVFPDPAEVRLDRPMNSYINPTLGPHGFLSKETSHIALTAMLRAVGR
LNNLRVAPGVQGQLKKIPQPGGYSAYLREDHGSYSIFPTTFRVQYDA
>CYP6001C2 Neosartorya
fischeri
82% to CYP6001C11 Aspergillus clavatus
NFIA_065200
Supercontig 574: 1021375-1025419 +
MLRRFSSTFKKKGDRESKQNGTAAAVANTNNNDNNKRHSKISAARKSSS
DDDRNEKKGDSVSPFEKYASVLHASRSPIPNQTGDGAYLEHEHTTSLLQDARHLGFKDFKTLKEVIESKLPGGQLIDDK
TMLMERIIQ LVSRLPHNSKHREELTNAFLTELWDSLPHPPLS
YMGNDYAYRS
ADGSNNNPTLPWLGAANTPYARTIAPLIIQPGGLPDPGLVFDTLFARQTFKPHPNKVSSVFFDWASLIIH
(1)
DIFQTDYKNPNVNKTSGYLDLSILYGDVQEEQNLIRTFKDGKLKPDSFSEPRLQAFPATCCVLMVMLNR
(2)
FHNYAVEQLAAINEDGRFTKPADNLSEEEAKKAWAKYDEDLFQTGRL
(2)
ITCGLYINITLYDYLRTIVNLNRTNSTWCL (0)
DPRAQMEGSRTTPSGLGNQCSVEFNLAYRWHSAISATDEKWTEDVYERLMGKPASEVSMT
ELLMGLGKYQAELPKDPSKRTFADLERQADGKFKDEDLVNLLVNAVEDVA
(1)
GSFGARNVPKVLKNVEILGIIQSRKWNVGSLNEFRKFFGLKPYETFEEINSDPDVAESLR
SLYDHPDFVELYPGIVAEEAKQPMVPGVGIAPTYTISRAVLSDAVALVRGDRHYT
(0)
IDYNPRNLTNWGYSEVRYDLSINQGCVFYKLATRAFPNWFKPDSIYAHYPMTIPSENR
KIMKDLGRESHYSWDRPRYTPPRVDLVSYSNAKLVAEQQNQFRAAWDDTVEFVFGKASKE
FKLSQDSAFIQKHADVMSKLLNKEEWHRSVKEFYEDITTKLLEDKTRRFGGLNQVDITKD
(2)
VGNLAPVIFASNVFSLPLRSKENSRGIYTEHEMFKVLATLYNCLYFDIDKTKSY
PLYHASQAVGEPLGKALEASVKALGGSSLLSGIFGSFRENNNALKEYGVHMTKQ
LLENGLGAHEIAWAQILPTVIAMVPGQAQA (0)
FTQIVDFYLSKEGSKHLPEIQRLAKQDTKESDEQLLRYCLEAVRL
NDHSGLYRQSETTLAVTDEAGEVTIQPGDKVFVSF (0)
AKANRDASVFPDPEEVRLDRPMNSYISPNLGPHGFLSKETSHIALTAML
RTVGRLNNLRVAPGVQGQLKKIPQPGGYSAYLREDHGSYSVFPT
(1)
TFRVQYDA*
>CYP6001C3 Ajellomyces capsulatus NAm1
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
MQFLHISSLAEYPTAQIIMWHPLSKLELCMDRAPRSLDPDVKTE
NNKLLRTPKNGHVNGKLKDAPLPVAKRSKGRRVERQEIEDTFAKYSEFSGDHSRMKKD
GSSGKFQEVRWMGWKGVRTLLEVVKSKTSGKLVDDRDYLMERIIQLVANLPPESSARE
QLTKTFVKSLWVSLPHPPLAYLGDEYRYRAADGSNNNPMFPRLGAANTPYARSVRPIT
IQPAALPDPGLIFDSLFARQEFKPHPTGVSSTDPRNQHISQTSSYLDLSTLYGDNQDD
QNQMRTFKDGKLKADTFSDPRLLALPPACSVILVLLNRFHNYVVEQLAQINENGRFTK
PHANLPPDQSAKAWVKYDNDLFQTGRLITCGLYINITLYDYVRTIINLTRSNTTWSLD
PRIDTKKVAAPESAESGVGNQVSFEFNLAYRWHSCIGQLDEKWINDIYHDLFGKSGED
ISMPELMVGMGKWKQKLPEDPSKRTFAKLKRQADGRFRDEDLARIITEATEEVAGTFG
PRNVPKALRAVEILGIQQARKFGCGTLNEFRKFFGLKQYESFEEINSDPEIAGQLRNL
YEHPDYVELYPGIVSEEPKIPMVPGAGICPTYTISRAVLSDAVALVRGDRFYTSDYNA
KSLTNWGYTETHYDLSINQGVPDSIYAHYPMTIPSVNKEIFAKLGRQSHFSWDRPALL
SPRIDLTSYNGAKTILQNSKDFRVTWEASLGSHLASQGFNESQAKVIDETFAQDSWRE
EVKQFYQDITQKLLKRNSVKIAGINQIDITRDLGNLTHVHFAASTFNLPIKTKDNSKG
VFTDHEMFMVMLAAFTSVFSDVDPTKSFPLRQVAREVGEQFGQVVESYVKSIKAFNPF
SSIIDRFQKDGNTLAKFGADATRRLLKAGLSVPQVALSYILPIICTAVPSQAQAFTQI
IDYYLSDEGKIHLPDINSLAKEDSLESDTKLLHYCMEGLRLNGPFSSYRDSNANILIN
DGGREVSINDGDTVFISSARDPNIFPRPDEVVLDRPLESYIHYTDGAFTCFGRDAQMV
ALSSMLRVVGRLDNLRPAPGPQGQLARISRPDGHFAYMREDWGGYSALPMTLKVHYDA
TEAQPIKIITNYLAVWLLSEQIMLTPSYDFIELLYCCTWYLFERGRFDISFSIAEKAV
EFAKRSLKIKEQAVADNALDKHHPQLANSYINIGVFIAGMNPRDAIRLHEKAIVIREG
SPKYADDQMQLLSLNYMNIGRCWWMVKGLDKATAAYEKSISIIKELEEATGAPFAQKS
WAMSALANVLIDKGKFDAAFDLFTQSVKVHQQVLGATHHKTVACYNKIAWFLRKQGEY
GMAM
>CYP6001C4 Aspergillus fumigatus
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
EU020167 PpoC-like
Revised N-term
MRPEPQTEGASSKTSDDSHARFVDTAPKRVHEVQRFNEPSREPPKGDVGAEQGGAFGRFK
DLSEVVHKATRPLPTETGNGTYIEDSSKGGSLWEDLLSLGIEDAKTVKDFVKTEALRRPI
DDKTMLMERIIQ (0)
MVAKLPDKSKIREKGTHKFLGILWNSLPHPPLS (2)
YVGDKYAYRSADGSYNNPTLPRLGAANTEYARTTE
ASKMRPASMPDPGLIFDSIFARETFKPHANNVSSIFFTWASLIIH
(1)
DVFQTGYPDQSINKTSSYLDLSTLYGDNQDEQN
MIRTFEDGKIKPDCFSEPRLHILPAASGVILIMLNRFHNYVAEQ
LAIINENGRFTKPKAEIIDPVEARLAWAKYDNDLFQTARLITCGMYINITLYDYLRTI
INLNRDNSTWNLDPRTHDDQDEIPTAQGNQCSVEFNLAYRWHSTIGRQDEAWTEKTYR
EIVGKPGQEATLQDLMDGMRKFNARMDKDPSKRTFAGLQRQGNGTFRDVDLVDILTRA
IEEVSGSFGPNNVPKVLRSVEILGIQQARKWNIGSLNEFRKFFDLKPYESFEEINPDP
YVADQLRHLYEHPDYVELYPGIVAEEPKEPMVPGVGIAPGYTVSRAVLSDAVTLVRGD
RFYTKEFNARNLTNWGFSEAKYNLEINQGCSFYRLALRAFPKWFKYDSIYPHYPMTIP
SENRVIMKALGREEDFSWDRPSYIPQRISVFDYANVRHILQDASNFRVMWGEATAYVF
GSKGWDFMLSGDAPTHANQRNIMSRALYRGQWHDAVKQFYLDITQQLLTEKSCRIGNV
NQVDISRDVGNLAHVHFASNVFSLPLKSREHPHGIITAHEMFEAMAVIFTAIFFDAEP
VKSFELRHKAREAANKLGRLVELNVKAIKSSGLIATLLGNMPANRNALFEYGVHMVER
LLQSGLDPEQVTWSQVLPTAVAMVPNQAQVFTQIIDYYLSDKGRKHLPDIKRFAKEDS
PASDEVLLRYCMEAIRLNGIFGSYRKSQTNLTLDDKGGKVHIKAGDNVFVSFIDANRD
PDVFPKPEEVDLNRPMESYIHYGVGPHTCLGSEASKVALTTMLRVVGRLDNLRRAPGA
QGELKKIPREHGFYTYMREDQSSFYPFSMSWKLHYDGEIPGKEQPVRGDFVCNVPGHWQN
>CYP6001C4 Neosartorya fischeri
95% to CYP6001C4 Aspergillus fumigatus = ortholog
NFIA_045480
MRPEPQTEGASSKPGNDSHAKFVDTGPKRIHEVQHFNELSREPPKGDVGAEQGGAIGRFKDLSEVVHKATRPLPTETGNG
TYIKDSSKGGSLWEDLLSLGIEDAKTVKDFVKTEALGRPMDDKTMLMERIIQMVAKLPDKSKIREKGTHKFLGILWNSLP
HPPLSYVGDKYAYRSADGSYNNPTLPLLGAANTEYARTTEASKMRPASMPDPGLIFDSIFARETFKPHPNNVSSIFFTWA
SLIIHDVFQTGYPDQSINKTSSYLDLSTLYGDNQDEQNM
MRTFEDGKIKPDCFSEPRLHMLPAASGVILIMLNRFHNHVA
EQLASINENGRFTKPKDEIIDPVEARAAWAKYDNDLFQTARLITCGMYINITLYDYLRTIINLNRDNSTWNLDPRTHDDQ
DEIPTAEGNQCSVEFNLAYRWHSTIGRQDEAWTEKTYREIVGKPAQEATLQDLMEGMRKFNARMDKDPSKRTFAGLQRQG
DGTFKDVDLVDILTRAIEEVSGSFGPNNVPKVLRSVEILGIQQARKWNVGSLNEFRKFFDLKPYESFEEINSDPYVADQL
RHLYEHPDYVELYPGIVAEEPKEPMVPGVGIAPGYTVSRAVLSDAVALVRGDRFYTKEFNARNLTNWGFSEANYNLEINQ
GCSFYRLALRAFPKWFKYDSIYAHYPMTIPSENRVIMKALGREEDFSWDRPAYIPQRISVFDYANVRHILQDASNFRVMW
GEATAYVFGPKGWDFMLSGDAPTHANQRNIMSRALYRGQWHDAVKQFYLDITQQLLTEKSCRVGNVNQVDISRDVGNLAH
VHFASSVFSLPLKSREHPHGILTEHEMFEAMAVIFTAIFFDAEPVKSFELRHKAREAAEKLGKLVEINVKAIKSSGLITT
LLGNMHANKNALFEYGVHMVERLLQSGLDPEQVTWSQILPTAIAMVPNQAQVFTQIIDYYLSDNGRKHLPDIKRFAKEDS
PASDEVLLRYCMEAIRLNGIFGSYRKSQTNLTLDDKGGKVHIKAGDKVFVSFVDANRDPNVFPKPKEVDLNRPMDSYIHY
GVGPHTCLGGEASKVALTAMLRVVGRLDNLRRAPGAQGELKKISREHGFYTYMREDQSAFYPFPMSWKLHYDGEIPGKEQ
PVRGDFVCNVPGHWQN*
>CYP6001C5 Botryotinia fuckeliana B05.10
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001557594.1 (BC1G_04254)
MEQPHQGGPARRLTLGVPKKSTSGNASSNPQVFEGPDHSVKRAG
IVGTLESLGKVISTANRPLNTETGDGSYDTKQEQSGLLDDLKALRIKDLETLQMTMKQ
ELGSSNLADDKTMLMEKLIQLVANLPGTSKTRVKLTEVLVDELWGSLEHPPASMLGDK
YNYRQADGSFNNIRFPDIGKAGTAYARSVTPKIVQPNPKPDPGLIFDTIMSRENGGFK
PHPNNISSMLYYIASIIIHDCFRTSHEDFNISMTSSYLDLSPLYGSNQDEQNNMRTLK
DGELKPDCFSEKRLLGFPPGVGCILIMFNRFHNYVVKQLATINENGRFTPPKDNLPDD
KKQAAWKKYDNDLFQTGRLITCGLYINIILLDYLRTIVGLNRVNSTWTLDPRIEMERN
SKPGTEAGVGNQCAAEFNLVYRWHSCISQRDEKWSEDLYMKIFGKSYKEVTMQELLIG
LGKLEAMTPEDPLQRDFAGMKRGTDGKLNDDDLVNELTASIEDLAGSSGANNVPAVLR
AVEILGMEQARAWKCATLNEFRKHFGLIPHEKFSDINSDPAVYEKLKVLFDEPDLVEL
YAGLVCEDAKKPMDPGVGIGPTYTISRSILSDAVTLVRGDRFYTTDYHPANLTNWGVT
EVKYDLNVNQGCVFYKLFIRAFPNHFSYNSIYAHYPLTIPSENKKIMEKLGRADDYSW
DKPVKVPERKNIVTFDGVKSVLTNAEVFGVDNWRRGLAYLMGKPGANFMLAGDGDFFA
ERRNQMKECLYQDKWHESVKNYYESIVPRLLKRWSYNIGGTTNQVDVIRDIDNSAHVH
FAANVFHLPLKTEENPKGVYTEHELYMVLAVIFIVIFFGDVDPAKTFSLRAAGLPVTQ
DLGQLVEQNVNFISKTSLVSGIVDTFMEENNALKDYGVHMVRHLLKAGLGVHETVWSQ
ILPTAGAMVANQAQVFGQVLDFYLGDGKEHLPEINRLAKLNTAEADDILLHYLLEGIR
MYGTFGAYRTCHQNITINDGSRKVECKPGDSVFVSFVSLAQDPKIYPDPKTVRLDRPV
DSYLVYGVGSHACLGGEASRVALTAMLKCIGRLDNLRRASGPQGEMKKVPREGGFYVY
MDKMMGSEFPFPTTMKICWDGGLNEPVPVVEKGKGKKNGA
>CYP6001C6 Podospora anserina DSM 980
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001904176.1 (PODANSg1229)
MSDYNGNGHKASNGTGVTALNGSSSSHGSSSAHQSREGMELVAS
QAKPRPTPLDLKPTGANRAGVANAFERYGQVMQSSVAPLPNQHGADTFSRSKKWGKLR
DDVKQLRLADYKTLLGVVKAKVKGEKIKDDKTMAMEKVIQLVSNLPSNSKTRTELTNS
FLSELWYTLEHPPSMYVGEKFQYRQADGSYNNVMFPQLGAAGTSYSRSVAANVVRQGA
LPDPNLIFESVMKRTEYTEHPNNVSSILWYWASIIIHDLFWTDYRDMSKSKTSSYLDL
SPLYGSNQDMQDTIRTFKDGKIKPDCFADKRLLGMPPGVGVFLIMFNRVHNHVAENLA
RINEDGRFSPPSPNLEGEKKEAAWKKYDNDLFQHARLITSGLYINITLLDYVRNIVNL
NRVDTTWTLDPRVETGINVDTKEGAERGTGNVCSAEFNLCYRWHSCISAKDDKWIQDF
YYDLFKKPGKDLSIHELIMGFGKFEGMIPDDPAERPFNKFQRGPDGKFNDDDLVNCIS
DAIEDPAGSFGARNVPESMRAVEILGIIQGRRWNVAGLNEFRKHFGLKPYEKFEDINS
DPGVAESLRRLYDHPDFVELYPGLVAEERKEPMVPGVGIAPTYTISRVVLSDAVCLVR
GDRHYTIDYTPRNLTNWGFNEVQYDLNINHGCVFYKLFLRAFPNHFKYNSVYAHYPMV
TPSENSKILKDLKRAHLFDFSRPGRIATPTEVTSYDGAQRIFAAEDKFKSTWNAGVAG
IRAKASPELSGDAAVHDRHRTTASRSLFTPELGTQIKAFYESLTDKLLTTKSYTLVPG
SKFADLVRDIANIVPTHFAASVFGLPLTTKENRKGIYTEHELYAVLQIIASALFVDSE
PVKLFPVVEAAKTVAGQLGTLVDKTVKSPKAAKNSVLNTFGVNFIKELKKAGLATHDI
TWNHVLPTAAALASSQGELFTQAVDYYLSPEGAAHVADITAIASQPSSSQNDALLLGY
VLEGIRLSGSARSHFEATTAGTVTASNGTELQIQPGSKVTINSSTASRDAAYFPEPET
VNPRRPLDKYIHFDAGPHAFLGKEISQIALTEMFRALFKRKNVRRAPGPQGELKKVPR
ADGNGVDYLREDWGALTPFPVTMKVMWDEV
>CYP6001C7 Neurospora crassa OR74A
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_954756.2
MSSHQNGTNGHSASTSDNGKESKSRNVIGPDPKAERTASMAKPR
PTSMKLPFTGASRQGVENAFERHRQTIQSAVQPLPTQQGAGTFSENKKWGKLSSDLMT
LRWADIKTLKHMVVAKIKGERLADDKTMIMEKVIQLVSNLPSNSKLRVELTNGFLGEL
WYTLEHPPSIYVGEYYQYRKADGSCNNIMFPQLGAAGTTYARSVRPNVIRQGALPDPE
LIFDSVMKRTEYKSHPNNVSSILWYWASIIIHDLFWTDYRDMSKSKTSSYLDLSPLYG
SNQDMQDTIRTFKDGKLKVDCYADKRLLGMPPGVSVLLIFFNRFHNYTCDNLIAINED
GRFNKPSPKLEGEKAEAAWKKYDNDLFQTARLITSGLYINITLLDYVRNIVNLNRVDT
TWTLDPRADTGIDVGTKDGAERGTGNVVSAEFNLCYRWHSCISAKDEAWIEDFYYELF
GKPGSDLSFHELIMGFGKFEGGIPADPADRPIRKDKGHFSRDANGKISDDELAECIAD
AIEDPAGSFGAKNVPPSMRAVEILGIIQGRKWNLAGLNEFRKHFGLKPYETFEDINSD
PGVSEALRRLYDHPDFVELYPGIVAEEHKSPMVPGVGIAPTYTISRVVLSDAVCLVRG
DRHYTIDYNPRNLTNWGYNEVQYDLNLKHGCVFYKLFMRALPNHFKENSVYAHYPMVT
PAENKKILTDLKRDHLFDWARPTRQPKPHQVKTHAGAQHVLDNDKEGTSGAYMSSWHA
GLESLLGKPLSNNNPDAHDSQRRDIHEQLYSAEWADQVKAFFAQTTDALLAGESYNVG
GHLLVDLVRDVGNIVPTLFAAKVFGISLQTKNNTNGLYTPQELYAVLAVIFAAIFYDH
DPVKTHQLRDAARTVATQLGTALESAVKSQTSFFGSLLGGGGSGSNNNALTAYGNDLV
KRLSKAGLSASDVAFGQVLPIVASSVPSIAEAFASAADFYLGEKGQAHLGAIQELARQ
PASASADAQLLGYVLEGIRLSGNALGAFRQASAVDAIKEEDGSEVRVQPGDRVFVSVK
SAAQSPTTFPSPEEVNPSRPLEAYKIFFFGTHSYLGHEVSQIALREMFRSLFKRSNVR
RAPGPQGQLKKITRELNEELSQTFYLREDWGAVTPFPVTMKVTWDE
>CYP6001C8 Nectria haematococca
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
Necha1/scaffold_11:165096-168594
e_gw1.11.503.1 [Necha1:49009]
Note the YRKAE seq is near the end of the PpoC
like gene in A. nidulans
The P450 motif is later, like it is added on
at the end.
MSSAEVKNGHATNGHSQEKAPAPKPQPKAAGQSNQKKEGALKSFKKLRVLSKRPLPTEMGDGSYRTVVNR
PRLKEDLRRLKIKDLKTLLEIVKAKAKGETQQDDKTMIMERTIQIVASLNDHSKVQEVLTNSFIDKLWNS
LDHPPMLYMGDQYRFRQPDGSLNNPYMPKLGAAKTPYSRSVRPKGMSLGAQPDPEAVFESVMARDGFKKN
PNNVSSILWYWATIIIH (1)
DLFWTNLKDPNQNDSSSYLDLSPLYGSTVEARDSIRTFEDGLLKPDTFADKRL
IGNPPGVCIILIMFNRFHNHVATNLADINEGGRFSKPGPNLDPEAAAAAWKKRDEELFETARLVTSGLYI
NITLIDYVRNIINLNRVDTTWTLDPRQEMGVSVGTKEGSESGTGNVVSAEFNLCYRWHSCISEMDDKWIQ
DFYVQLLGDNYGAMDMRALMMALKKFEMSVPQDPAERTFGGFKRGKDGKFSDNELVDALATAIEQPGGAF
GGRNVPRIMKPVEMLGIIRGRKWNLAGLNEFRKHFGLKAYDTFEEINSDPEIAESLRNLYQHPDYVELYP
GIVAEEAKTPMVPGVGIAPTYTISRVVLSDAVALVRGDRYYTTDYHPRNLTNWGYKEVDYDLNINHGCVF
YKLFIRAFPQHFKGNSVYAHYPMVIPSENRKILTDLKRADRFDFDRPSFTPARINIVGYNAAKYILENQE
IYKVCWDEGLGHLMGEGGRRFMLSGDGAFFAQQRRCMGALLYNDTWKSAIKSFYSMIAEKLLAEKSYKLA
GKTQVDVVRDVGNLAHTHFVSRMFNLPLKTKENPKGLFSEQELYKILAVIFVCIFFDIDPAKSFPLRQGA
REVAQALGKVVEMNVKLSNGIGMKGLFTGKANKDDPLAAYGVNMAKGLKKAGLSTEDIVWSQILPTAGAM
VPNQAQV (0)
FAQTLDWYLSPAGEKYRPELHRIAALETGDETDALLLGYAMEGIRMAGTFGLYRKAESADVIE
EDNGERVEVK AGDRVFVSFVSAAKDPKIFPNPEVVDPRRPLESYIHYGTGPHECLGRNISQVALTELFRA
LFRKKGLRRVPGAQGELKKVPR
PGGFYVYMTEDWGSIWPFPTSMKVTWDGE*
>CYP6001C8 Fusarium oxysporum
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
gene model FOXG_12909
ortholog to CYP6001C8 Nectria haematococca
name revised for CYP6001C9
MAEHKNGVATNGYEKKSSPASSSTKSEAKPLPNSDKKDGIVKSFKQLRVASKRPLPKEMGDGSYRVVENRPGLKQDIRRL
RGRDLKTLLEIVKAKVKGETQQDDKTMIMERTIQLVANLSDHSKVQESLTNSFISQLWNSIDHPPMLYMGDKFRFRQPDG
SNNNPYLPQLGAARTPYSRTVRPKGMSLGAQPDPEAIFESVFARDAFRKNPNNVSSILWYWATIIIHDPNQNDSSSYLDL
APLYGSTEKDRDSIRTFKDGQLKPDCFADKRLIGNPPGVPILLIMFNRFHNHVATNLADINEGGRFSKPAEHLSPEAADA
AWKKRDTELFETARLVTSGLYINITLIDYVRNIINLNRVDTTWTLDPRQEMGVSVGTKDLSESGTGNVVSAEFNLCYRWH
SCLSEMDDKWVQDFYTELLGENYGPMNLQTMMKALKAFEASVADEPSERTFGGFKRGPDGKFNDDELVEALATAIEQPGG
AFGGRNVPRIMKPIEMLGIMRGRKWNLAGLNEFRKHFGLKAYETFEDINSDPSVADALRNLYQHPDYVELYPGIVAEEAK
TPMVPGVGIAPTYTISRVVLSDAVALVRGDRYYTTDYNPRHLTNWGYKEVDYDLKVNHGCVFYKLFLRAFPQHFKGNSVY
AHYPMVIPSENEKILTNIKRADRFDFSRPEPTATRINIIGYNAAKYILEDQQKYRVCWEEGLKHLMGEAGGRFMLSGDTA
LHAQQRKCMGKLLYNDTWRNAVKSFYATTAEKLLAEKSYRLAGKMQVDVVRDVGNVAHTHFVARMFNLPLKTSENPKGVF
SEQELYMILAVIFVCIFFDIDPAKSFPLRQGAREVAQKLGGIIEMNVKLANSIGVKGLFTSKPDKNDDPLARYGENMAKG
LKKAGLSTEDIVWSQILPTAGAMVPNQAQVFAQTLDWYLSPAGEKYRPELARIAALETGDETDALLLGYAMEGIRMAGTF
GLYREATGPDTIHEDDGRSIPVNAGDRVFVSFVQAAQDPKIFPNPGVVDPKRPLDKYIHYGVGPHACLGRDISQVALTEL
FRAVFRKKGVRRVPGAQGELKKVPRPGGFFVYMTEDWGSIWPFPTSMKITWDE
>CYP6001C8 Fusarium verticillioides
98% to CYP6001C9 Fusarium oxysporum = ortholog
FVEG_11670
Name revised from CYP6001C9
MAEHKNGVATNGYEKRASPASSSTKSEAKPLPNGDKKDGIVKSFKQLRVASKRPLPKEMGDGSYRVVENRPGLKEDIRRL
RGRDLKTLLEIVKSKVKGETQQDDKTMIMERTIQLVANLSDHSKVQESLTNSFISQLWNSIDHPPMLYMGDKFRFRQPDG
SNNNPYLPQLGAARTPYSRTVRPKGMSLGAQPDPEAIFESVFARDAFRKNPNNVSSILWYWATIIIHDPNQNDSSSYLDL
APLYGSTEKDRDSIRTFKDGQLKPDCFADKRLIGNPPGVPILLIMFNRFHNHVATNLADINEGGRFSKPAEHLSPEAAEA
AWKKRDTELFETARLVTSGLYINITLIDYVRNIINLNRVDTTWTLDPRQEMGVSVGTKDLSESGTGNVVSAEFNLCYRWH
SCLSEMDDKWVQDFYTELLGENYGPMNLQTMMKALKAFEASVADEPSERTFGGFKRGPDGKFNDDELVEALATAIEQPGG
AFGGRNVPRIMKPIEMLGIMRGRKWNLAGLNEFRKHFGLKAYETFEDINSDPSVADALRNLYQHPDYVELYPGIVAEEAK
TPMVPGVGIAPTYTISRVVLSDAVALVRGDRYYTTDYNPRHLTNWGYKEVDYDLNVNHGCVFYKLFLRAFPQHFKGNSVY
AHYPMVIPSENKKILTDIKRADRFDFSRPEPTATRINIIGYNAAKYILEDQQKYRVCWEEGLKHLMGEAGGRFMLSGDTQ
LHAQQRKCMGKLLYNDTWRNAVKSFYATTAEKLLTEKSYQLAGKTQVDIVRDVGNVAHTHFVARMFNLPLKTSENPKGVF
SEQELYMILAVIFVCIFFDIDPAKSFPLRQGAREVAQKLGGIIEMNVKLANSIGVKGLFTSKPDKNDDPLARYGENMAKG
LKKAGLSTEDIVWSQILPTAGAMVPNQAQVFAQTLDWYLSPAGEKYRPELARIAALETGDETDALLLGYAMEGIRMAGTF
GLYREATGPDTIHEDDGRSIPVNAGDRVFVSFVQAAQDPKIFPNPGVVDPKRPLDKYIHYGVGPHACLGRDISQVALTEL
FRAVFRKKGVRRVPGAQGELKKVPRPGGFFVYMTEDWGSIWPFPTSMKITWDE*
>CYP6001C10
Fusarium graminearum
FG10960.1
AACM01000456 FGcontig1.456_scaffold8
88% to CYP6001C9
Fusarium verticillioides
very poor match
39% to FG02668.1
linoleate diol
synthase a modified P450 fused to a dioxygenase
MASNQVKNGAVASNGYGKEKSPSSASSSQKNEVPAPPHNKSEGLVKSIKK
LRLASKRPLPTEMGDGSYRQVATRPGLKQDVRRLRGKDLKTLLEIISSKL
KGEMQQDDKTMIMERTIQLVANLSDHSKVQEALTNSFIAQLWNSIDHPPM
LYMGNKYRFRQPDGSWNNPYLPQLGAARTPYSRTVRPKGMSLGAQPDPEA
IFESVFARGIFRKNPNNVSSILWYWATIIIHDLFWTNTKDPDQNDSSSYL
DLAPLYGSTVKDRDSIRTFKDGQLKPDCFADKRLIGNPPGVPIILIMFNR
FHNHVATNLADINEGGRFSKPGAHLDAEAAAAAWKKRDEELFETARLVTS
GLYINITLIDYVRNIINLNRVDTTWTLDPRQEMGVSVGTKNLSESGTGNV
VSAEFNLCYRWHSCLSEMDEKWVEDFYTELLGENYGPMNLQTMMRALKAF
EATVAEEPSERTFGGFKRGPDGKFNDDELVEALATAIEQPGGAFGGRNVP
RIMKPIEMLGIMRGRKWNLAGLNEFRKHFGLKAYDTFEDINSDPEVADAL
RNLYQHPDYVELYPGIVAEEAKTPMVPGVGIAPTYTISRVVLSDAVALVR
GDRYYTIDYHPRNLTNWGYKEVDYDLNINHGCVFYKLFLRAFPQHFKGNS
VYAHYPMVIPTENHKILTDLKRVDRFDFSRPAPTATRINIVGYKAAKYIL
EDQAKYRVCWEEGLKHLMGEGGGRFMLSGDTALHAQQRKCMGRLLYNDTW
RNAVKSFYSTTAEMLLNEKSYTLAGKKQVDVVRDVGNVAHTHFVARMFNL
PLKTKQNPKGVFSEQELYMILAVIFVCIFFDIDPAKSFPLRQAAREVAQQ
LGKIVEMNVKLATSVGIKGLFTSKPNKNDDPLAAYGENMAKGLKKAGLSI
DDIVWSQILPTAGAMVPNQAQVFAQTLDWYLSPAGEKYRPELHRIAALET
GDETDALLLGYAMEGIRMAGTFGLYREATTADVIQEDDGREVPVKAGDRV
FVSFVTAAKDPNIFPDPEVVDPRRPLDSYIHYGVGPHACLGRDISQVALT
ELFRALFRKKGLRRVAGAQGELKKVPRPGGFFVYMTEDWGSIWPFPTSMK
VTWDE*
>CYP6001C11 Aspergillus clavatus
81% to CYP6001C2 Aspergillus fumigatus
ACLA_039980
MLRRFSSTFNKKKGDREPKQNGVATTTTTTTPTTNKRYSKVPEGHKSSSEEERNEKKGGAVSPFEKYASVLHASRTPIPN
QTGDGAYLEHEHTTSLLQDARHLGFKDLATLKEVIKNKATGQLVDDKTMLMERVIQLVSSLPHNSKHREELTHSFLDELW
GSLPHPPLSYMGSEYAYRSADGSNNNPTLPWLGAANTAYARTIAPLIIQPGGLPDPGLVFDTLFARQSFKPHPNNVSSLF
FDWASLIIHDIFQTDYRNPHVNKTSGYLDLSILYGDVQEEQNLIRTFEGGRLKTDSFSEPRLQAFPAACCVLLVMLNRFH
NHVVEQLAAINENGRFTQPRDGLPEDQAKKAWEKYDEDLFQTGRLITCGLYINITLYDYLRTIVNLNRTNSTWCLDPRAQ
MEGNNTTPSGLGNQCSVEFNLAYRWHSAISANDEKWTEKIYEDLMGKPASEVSMTELLMGLGKYEAGLSKDPSQRTFAGL
ERQADGRFRDEDLVNILTGAIEDVAGSFGARNVPKVLKNVEVLGILQSRKWNVGSLNEFRKFFGLKPYETFEEINSDPDV
AESLRSLYDHPDFVELYPGIVSEEAKEPMIPGVGIAPTYTISRAVLSDAVALVRGDRYYTIDYNARNLTNWGYSEVRYDL
SINQGCVFYKLATRAFPDWFKSDSIYAHYPMTIPSENRKIMKNLGREAHYSYDRPQYIPPPVDLLSYPSAKLVAEQRKDF
HTVWADTVEFVFGKASKNFKLSEDTAFIERQRETISKLLSQDEWQRNVKEFYEEITTGLLEEKTRRFAGINQVDITRDIG
NLVPVIFASNLFSLPLRSKENSRGIFTEHEMFNVLAVLYNCIYFDIDKTKSFPLHHASQAVGEQLGKAVEANVKSLGGSS
LLSGILGGSRDNKNALKEYGAHMTKQLLENGLGASEITWSQILPTVIAMVPSQAQAFTQIIDFYLSKEGSKYLPEIQRLA
REESKESDEQLLRYCMEAIRLNKTSGAYREARTSLTVTEETGQVTLQPGDKVFVGFAKANRDPSVFPDPSEVRLDRPLDA
YINHSLGPHGFLSKETSQIALTAMLRAVGRLNNLRRAPGAQGEVKKVPIADGYSAYLREDHGSYSVFPTTFRVHYDV*
>CYP6001C12 Aspergillus oryzae
100% to CYP6001C Aspergillus flavus
Supercontig 6: 2075682-2079724 (-) strand
MLRRISTNFKKSKNDRETKQNGTQNGAQNGTQVNGDKRQSKVSPARKSADQEPSRKAANGASVFGKYAQVLHASQSPLPN
QTGDGATFEQRHGSLVQDLKSLHLEDAATLKQLSMNKIKGVPVDDKTMLMEKIIQ
(0)
IASSLPDNSENRTKATNLFLNQLWDSLPHPPLS (2)
YVGPEYSYRSADGSNNNPTLPWLGAANTPYARSIAPLTIQPGGLPDAGLVFDSLFAREKFNPHPNKVSSLFFDWASLIIH
(1)
DIFQTDHANPHINKTSGYLDLSILYGDVQEEQDLIRTHRDGKLKPDSFSEPRLQAFPAACCVMLVMLNR
(2)
FHNYVVEQLAEINENGRFTKPSPDLSEEKAKKAWAKYDEDLFQTGRL
(2)
ITCGLYINITLYDYLRTIVNLNRVNSTWCL (0)
DPRAQMEGNDPTPSGLGNQCSVEFNLAYRWHSAISANDEKWTEQIYEELMGKPAKDVTVLDLKKGLGKYAMGLSKDPSERTFAHLK
RQEDGTFKDEELVSILANAIEDVA (1)
GSFGARNVPKCLRAVEIMGIEQARSWNVGSLNEFRKFFDLKPYERFEDINSDEEVV
EALRHLYGHPDYVELYPGIVAEDAKQPMVPGVGIAPTYTISRAVLSDAVALVRGDRFYT
(0)
VDYNPRNLTNWGYNEVRYDLN
VNQGCVFYKLATRAFPNWFKSDSIYAHYPMTIPSENRNIMKDLGRESDFSYERPSFTPPHVNLVSYPNVKLALEREEDFR
VVWNGNTPLASAKGGDDFWSKSLDNDQWRNSIKEFYEDITAKLLQEKSGNLAGLKQVDITRD
(2)
IGNLAPVHFASKLFSLPL
KTKENSRGVFTDNETFMSMAVIFTSIFFDVDKTKSFSLHHAARAVAEQLGHSVENHVKSINSPSFLSGIIGNRRNDHNAL
KEYGDQLIKKLLESGLGVSDVTYSQVLPAAVAMVHNQAQM
(0)
FTQIIDYYLSEGKKHLPEINRLSKEDSKDSEDKLMRYCLE
GFRLNGTFGSYREAQTDLSMTEETGNVNIKRGDRVFVGA
(0)
VKANRDPQVFPDPNEVHLDRPLESYIQYGLGPHTGLGKETT
LLALTSMLRVVGGLDNLRRAPGPQGELKKIHREGGYYVYLREDWGSYSPFPT
(1)
TFKVHFDGAIPAPKKRLTYLGN*
>CYP6001C12 Aspergillus
flavus
69% to CYP6001C1 Aspergillus nidulans
AFL2G_02242
MLRRISTNFKKSKNDRETKQNGTQNGAQNGTQVNGDKRQSKVSPARKSADQEPSRKAANGASVFGKYAQVLHASQSPLPN
QTGDGATFEQRHGSLVQDLKSLHLEDAATLKQLSMNKIKGVPVDDKTMLMEKIIQIASSLPDNSENRTKATNLFLNQLWD
SLPHPPLSYVGPEYSYRSADGSNNNPTLPWLGAANTPYARSIAPLTIQPGGLPDAGLVFDSLFAREKFNPHPNKVSSLFF
DWASLIIHDIFQTDHANPHINKTSGYLDLSILYGDVQEEQDLIRTHRDGKLKPDSFSEPRLQAFPAACCVMLVMLNRFHN
YVVEQLAEINENGRFTKPSPDLSEEKAKKAWAKYDEDLFQTGRLITCGLYINITLYDYLRTIVNLNRVNSTWCLDPRAQM
EGNDPTPSGLGNQCSVEFNLAYRWHSAISANDEKWTEQIYEELMGKPAKDVTVLDLKKGLGKYAMGLSKDPSERTFAHLK
RQEDGTFKDEELVSILANAIEDVAGSFGARNVPKCLRAVEIMGIEQARSWNVGSLNEFRKFFDLKPYERFEDINSDEEVV
EALRHLYGHPDYVELYPGIVAEDAKQPMVPGVGIAPTYTISRAVLSDAVALVRGDRFYTVDYNPRNLTNWGYNEVRYDLN
VNQGCVFYKLATRAFPNWFKSDSIYAHYPMTIPSENRNIMKDLGRESDFSYERPSFTPPHVNLVSYPNVKLALEREEDFR
VVWNGNTPLASAKGGDDFWSKSLDNDQWRNSIKEFYEDITAKLLQEKSGNLAGLKQVDITRDIGNLAPVHFASKLFSLPL
KTKENSRGVFTDNETFMSMAVIFTSIFFDVDKTKSFSLHHAARAVAEQLGHSVENHVKSINSPSFLSGIIGNRRNDHNAL
KEYGDQLIKKLLESGLGVSDVTYSQVLPAAVAMVHNQAQMFTQIIDYYLSEGKKHLPEINRLSKEDSKDSEDKLMRYCLE
GFRLNGTFGSYREAQTDLSMTEETGNVNIKRGDRVFVGAVKANRDPQVFPDPNEVHLDRPLESYIQYGLGPHTGLGKETT
LLALTSMLRVVGGLDNLRRAPGPQGELKKIHREGGYYVYLREDWGSYSPFPTTFKVHFDGAIPAPKKRLTYLGN*
>CYP6001C13 Aspergillus oryzae
Supercontig 26: 1555206-1559023 (-)
strand
MKGVPSSAEASNSIPGSSLPSQRAHEPLTHKQPTLDHPRKQSVQSISSEHGGMAENFSKITKVVQAARRPLPTETGDGTY
IEPENGGSLWRDLRALGIKDANTLKDLIENKAGGLVKGSGQVVDDKTMLMERIIQ
(0)
LVAKLPTESRNRVKLTNMFLGELWDSLPHPPLS (2)
YVGDKYAYRSADGSYNNPTLPWLGAANTEYARTIEPLKVRPASLPDPGLVFDSLFARDTFNPHPNNVSSVFFTWASLIIH
(1)
DIFQTGHPDENFNKTSSYLDLSILYGDNQEEQNMMRTFKDGKIKPDSFSEPRLHALPAACGVILVMLNR
FHNHVVEQLAAINENGRFTKPPERILDPVEARAAWAKYDNDLFQTGRL
ITCGLYINITLYDYLRTIVNLNRDNTTWTL
DPRAHMEHDTVPTALGNQCSVEFNLAYRWHSTISRKDEAWTEQAYQAIVGKPGSEATVEDLMSGMRRLGANMPKDPSKREFAGLK
RQSSGKFKDEELVDILTMAIDEVA
GSFGARNVPKVLRSVEILGMEQARRWNVGSLNEFRKFFDLKPYQSFEEINSDPEVA
DQLRHLYEHPDNVELYPGIVAEDAKKPMIPGVGIAPGYTVSRAVLSDAVALVRGDRFYT ()
KEYNSRNLTNWGYEEANYDLE
INQGCVFYKLALRAFPQYFKQNSIFAHYPMTTPSANRDIMKMLGREEDFSWDRPSYTPPRTTLFDYANVRRILEDSSNFR
VIWDEATGYVFGKGGYDFMLSGDSPFHANQRRIMKESLYRSQWHEAVKEFYLEITEQLLSEKSCRVGNVNQIDISRD
()
VGNLAHVHFASNIFSLPLKTKEHPHGVLTEHEMFDVMSIIFTAIFFDVDPSKSFRLRHMARKAAETLGPLVEANVKAVSSASF
LSTLIDGIRSNKNALSGYGVHMIRRLLDHGLDASEVTWSQILPTAVAMVPNQAQV ()
FTQIIDYYLSDEGKEHLPNIQQLAK
EDTPASDEMLLRYVMEAIRLNGIFGSYRKSHTNLTLDDKNKMVQIKPGDTVFVSF
(0)
VDANRDPNVFPNPKKVDLNRPMESY
IHYGVGPHTCLGGEASKVALTAMLRVVGRLKNLRRAPGPQGELKKIPRDHGFYTYMRADETSLYALPM (1)
TWKLHYDGTIPGRERSVPEKLTCNVPGHWHD*
>CYP6001C13 Aspergillus flavus
74% to CYP6001C4 Neosartorya fischeri
99% to CYP6001C13 Aspergillus
oryzae
AFL2G_11739
MKGVPSSAEASNSSPGSSLPSQRAHEPLTHKQPTLDHPRKQSVQSISSEHGGMAENFSKITKVVQAARRPLPTETGDGTY
IEPENGGSLWRDLRALGIKDANTLKDLIENKAGGLVKGSGQVVDDKTMLMERIIQLVAKLPTESRNRVKLTNMFLGELWD
SLPHPPLSYVGDKYAYRSADGSYNNPTLPWLGAANTEYARTIEPLKVRPASLPDPGLVFDSLFARDTFNPHPNNVSSVFF
TWASLIIHDIFQTGHPDENFNKTSSYLDLSILYGDNQEEQNMMRTFKDGKIKPDSFSEPRLHALPAACGVILVMLNRFHN
HVVEQLAAINENGRFTKPPERILDPVEARAAWAKYDNDLFQTGRLITCGLYINITLYDYLRTIVNLNRDNTTWTLDPRAH
MEHDTVPTALGNQCSVEFNLAYRWHSTISRKDEAWTEQAYQAIVGKPGSEATVEDLMSGMRRLGANMPKDPSKREFAGLK
RQSSGKFKDEELVDILTMAIDEVAGSFGARNVPKVLRSVEILGMEQARRWNVGSLNEFRKFFDLKPYQSFEEINSDPEVA
DQLRHLYEHPDNVELYPGIVAEEAKKPMIPGVGIAPGYTVSRAVLSDAVALVRGDRFYTKEYNSRNLTNWGYEEANYDLE
INQGCVFYKLALRAFPQYFKQNSIFAHYPMTTPSANRDIMKMLGREEDFSWDRPSYTPPRTTLFDYANVRRILEDSSNFR
VIWDEATGYVFGKGGYDFMLSGDSPFHANQRRIMKESLYRSQWHEAVKEFYLEITEQLLSEKSCRVGNVNQIDISRDVGN
LAHVHFASNIFSLPLKTKEHPHGVLTEHEMFDVMSIIFTAIFFDVDPSKSFRLRHMARKAAETLGPLVEANVKAVSSASF
LSTLIDGIRTNKNALSGYGVHMIRRLLDHGLDASEVTWSQILPTAVAMVPNQAQVFTQIIDYYLSDEGKEHLLNIQQLAK
EDTPASDEMLLRYVMEAIRLNGIFGSYRKSHTNLTLDDKNKMVQIKPGDTVFVSFVDANRDPNVFPNPKKVDLNRPMESY
IHYGVGPHTCLGGEASKVALTAMLRVVGRLKNLRRAPGPQGELKKIPRDHGFYTYMRADETSLYAFPMTWKLHYDGTIPG
RERSVPEKLTCNVPGHWHD*
>CYP6001C14 Aspergillus terreus
64% to CYP6001C13 Aspergillus oryzae
ATEG_03171.1
MKFNQTTEAEGSNPQLVVRGRTPETEPAGKASINRVSSPLVNVVSAPPVNESPPMSNGENETKNTVHNIEELEQESQRPL
PKETGDGTYVEEETSKSTLWQDLRRLGIQDVNTLASMIKTEATGQYIDDKTMLMEHIMQLVSKFPDGSKTRETLTNLFLN
ELWTSLPHPPLSYVGDKYAYRSADGSYNNPTLPLLGAANTEYARSIAPRTVRPNSLPDPGLVFDSVFARDQFHPHPNRVS
SMFFVWASLVIHDIFQTGHPDLNMNKTSSYLDLSILYGDTQEDQDQIRTFKDGKLKPDSFSEPRLQALPPASCVILVMLN
RYHNHVVEQLAIINEGGRFTKPQTSKMDPEQARKAWLKYDNDLFQTGRLITCSLYINITLYDYLRTIVNLNRTNSTWCLD
PRAQSEGQKPIPSGLGNQCSVEFNLAYRWHSTISNKDEKWAEKVYKEIVGKDGEEASVSDLLLSMKKFAGNLGHDPAQRT
FAGLQRQADGMYRDEDLVQILTSATEEVAGSFGARNVPKVLRSIEMMGIEQARKWNVGSLNEFRKFFKLKPYQTFEEINS
DPDVADALRHLYDHPDNVELYPGIVAEEAKEPMVPGVGIAPTYTISRAVLSDAVALVRGDRFYTVDYNSKNLTNWGFAES
QFDLGINQGCVFYKLAMRALPNWYKPDSIYAHYPMTIPPENKVIMRTLGRENDYSWDRPAYMPPGINVCAYPNVWGILND
PTCFRVTWGDAMGSIFGKPGLDFMQSGDSRIHSNQRVTMASALYREHWQEQIKSFYLSITGQLLKERSYKLGKVHQVDLT
RDVGNIAHVHFAADIFSLPLKTEKNPRGIFTEHELYEMLSTIFTYIFFDDDAPRSFQLRRDARAAAQKLGTVVEATVKST
GGSGFISSLVDSFRSPGNAALKDYGVHMVRRLLDSGLDAAEATWSQILPTAVVMVANQAQAFTQIMDYYLSPAGAQHLPL
IQRLAQYDSPEADEKLLRYCMEGMRLNGTFNLARESLTNAVLEERGRRVHLTPGSKILLNIVEASRDPDVFPDPDEVRLD
RPMSAYLHYGEGPHMCLGREASKIALTAMMRVVGRLPNLRRAPGPQGELKMVPGPNGCYSYLDEDETRLMPLPTTFKVHF
DGPV*
>CYP6001C15 Aspergillus niger CBS 513.88
72% to CYP6001C12 Aspergillus oryzae
An02g07930
MLRRFSSTFKRSSKGDRDSKPNGTQ
VNGQKRQSKVPAPRKSSSDESHSDHGVESDDGVSVFEKYAQVLHASRRPLPNQNG
DGTYLEQEHSGSLFKDLRALGFKDIGTLKDLIKTKAKGEYIDDKTMLMERIIQLVSSLPGNSKTRVDLTNAFLDELWGSL
PHPPLSYMGEEYAYRSADGSNNNPTLPWLGAAGTPYARSIAPLTIQPGGLPDAGLVFDCLFAREKFTPHPNKVSSLFFDW
ASLVIHDIFQTDYTNSHVNKTSAYLDLSILYGDDQEDQNLVRTFKDGKLKPDTFSEQRLQAFPPACSVLMVMLSRFHNWV
VEELAAINENGRFNKPDPRLDEEKARKAWEKYDNDLFQTGRLVTCGLFINITLYDYLRTIVNLNRSNSTWCLDPRVQMEG
TKSTPSGLGNQCSVEFNLAYRWHSAISANDEKWTEEIYEELMGKPASEVSMRELLVGLGKYEREIPKDPSKRTFAGLKRQ
EDGTFKDEDLVRILANAIEDVASSFGARNVPKVLRSVEILGIEQGRKWNVGSLNEFRKFFDLKPYETFEEINSDPDVADS
LRHLYEHPDYVELYPGIVAEEAKEPMIPGVGIAPTYTISRAVLSDAVALVRGDRYYTIDYNPRNLTNWGYNEVRYDLNIN
QGCVFYKLAMRAFPNYFKPDSIYAHYPMTIPSENRNIMKNLGRESHYSYDRPRYTEPVPNLLSYANAKLVLNNQKDFTVP
WGGLSSIHAGKGGADFWSKSFDNEQWRNSVKEFYEDATLKLLNEKSCKLAGNKQVDIARDVGNLVPVHFVSKVFSLPLKT
KSNPRGIFTEHEMFMIMAVVFNSTFFDVDPTKSFPLQHAARAVSQELGKVVEAHVKSINHPGFLHGIIDSFRDDHNALKD
YGDQLIKRLLESGLGVSDVTWGQILPAAVEMVHTQSQMFTQIIHFYLTEGQKYLPEINRLANENTAEANDRLTRFCLEAV
RLNGNLGIYREAQADINVSDETGQYSVKSGEKVFVGSSKANRDPQAFPSPDEVRLDRPLDSYLHYGLGPQSGLGKDATLA
AVTAMVRVVARLDTLRPAPGAQGQLKKIPQEAGFSVYMREDYGSYSPFPTTYKVHYNGDVPAPKRQVTTA*
>CYP6001C16 Aspergillus terreus
78% to CYP6001C12 Aspergillus oryzae
ATEG_04755.1
MLRRFSTQFKKSKGDRESKQNGTPGPANNSSKRQSKLAQPRKSSSSSSDGERSAKNEDGVPAFEKYAQVLHASRSPLPNQ
TGDGATSAHDHQTTLFQDLRSFGFKDFGTLKEVIATKAKGEHVDDKTMVMERIIQLVSGLPANSKSRTELTHLFLDQLWE
SLPHPPLSYMGSDYAYRSADGSNNNPTLPWLGAANTPYARSIAPLTIQPGGLPDAGLVFDSLFARDKFRPHPNKVSSVFF
DWASLIIHDIFQTDHQNPNINKTSGYLDLSILYGDVKEEQDLVRTHKDGKLKPDAFSEPRLQAFPATCCVLLVMLNRFHN
HVVEQLAEINENGRFTKPSPDLPEDKAKAAWEKYDEDLFQTGRLITCGLYINITLYDYLRTIVNLNRVNSTWCLDPRAQM
EGSSSTPSGLGNQCSVEFNLAYRWHSAISANDEKWTEQVYQDLMGKPAEEVSVEELLGGLMKYGRSLEKDPSKRTFAGLQ
RQADGTFKDEELVEILTNAVEDVAGSFGARHVPKALKAVEVLGINQARQWNVGSLNEFRKFFDLKPYESFEEINSDPDVA
DALRNLYEHPDYVELYPGIVAEEAKEPMIPGVGIAPTYTISRAVLSDAVALVRGDRHYTIDYNPRNLTNWGYNECRYDLS
INQGCVFYKLATRAFPNWFKPDSIYAHYPMTIPSENRNIMKNLGRESHYSWERPKFTPPQVNLVSYPNVKLALEQEKQFR
VIWSGNTPLRPAKGGDDFWSKALNNDEWRKNIKEFYEDMTIKLLNEKSCKLGGIRQIDITRDLGNLAPVHFASKVFSLPL
KTKQNSKGVFTEHEMFMIMAVVFTSVFFDVDPTKSFPMHFASRAVSQQLGSAIESHVKSIGHPGFLSAIIDSFRDDDNVL
KEYGDQLIKKLLDSGLGVSDVTYSQILPTAVSMVHNQARMFTHIVDYYVTEGKKHLPEINRLAKETTPEADEKLTRYCLE
AFRLFGTFGSYREAQTDFTVNDGSGPVDIKQGDKVFVGAVKANRDPSVFPDPDEVRLDRPLDSYIQFGLGPHAGLGKEAT
LLALTAMLRVVGRLDNLRPAPGPQGQLKKIPREGGYYVYLREDWGSYSPFPTTFKVHFDGELPAPKKRGIASA*
>CYP6002A1 Emericella nidulans
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
PpoB AY940146
MAPFMQNGSDADDLSSSKSKQSTLTSLLSSVHADLLSQAHRIPA
DIRTLRELSQAGLQGGLIDDKKYLNIMYPHLGASGSHYARTVTPKHPRPAVLPDPGLI
FDSLLAREGPAKEHPAEISSNLFYFAIIIIHGDFQFRSYTEQTQVRTFTDGLLKPDTF
AEKRLLSQPPGVCALLVAFNRFHNYVVTELARINEAGRFDLPTGGQEKSPDYVWALQK
RDEDLFQTGRLYIIPSSSNTTTDIDKANACMGNRVTCGLYVSIILNDYLRTILNLNDN
PTNSDWKLDPRKNLSVFDSEGLPRGVGNQVSAEFNMIYRWHATTSNEDEKWLNELSIR
VFGSKVDPSTLSVQRYLNGLHEYLGKTAPGEPNTWTFGDLNRGKDGMFADKDLVKLLH
DGCEKVAADVNSDPKVAEALEALYGHPDNIELYVGVQAEEAKKPFLPGAGLCPGFTIS
FAILSDAVALVRGDRFYTVDYSPVNLTNFGFNTAESDPDVANGGVMYKLLMRAFPGWY
EPNNVYALYPFTIPAKNKEVFEKYGRADTLEFKRPEYTRPPVAITSWKGVVELLNNPK
AFRVPCMLAYLALRYHIQPWFIYPLTGWYEGNRNTFRLTKHDYMLSGDSVANSEQRTF
MAERLYRVPDALEQVRRFYESITADLIRRNSMRLGSSSCQIDIVRDVCNLAHAYFCSE
FFNIPLKPKDGHNGNGSGNKHLETTDAYTPKELAEALFAQFAYVFLDIDPVQSRKNRV
VAYRETQRMGDIMTQVVSATSESGYGLASASGYLFNRPSWISGGKNSSGLSMNGYGPQ
LVKRLREGGKSVEEVVWMIIPTAAAACATQATGWAQMLDLYLSDRYFTHWPAIQELAR
SDKPEAFEKLKRYALEGFRLSTPANGVLRNCNTATTTLKDGSATKSISKGDTVFADFA
SAGMDPDTFPNPEEIRLDRPLQLYIHHGWGTHACLGRAIVTTAAAALLKIVGRLDGLR
RANGMQGELFRKEVGGFRMFLDEKGESWRVFPQNMKVVFDSLDGLKA
>CYP6002A2 Fusarium oxysporum
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
FOXG_16700, FOXG_16765 identical models
MSTDEFLQGLRKWSWSLPGDPEKWTFGGLTRLEDGRFPDAELVRLLQTGTENVAGKLFFKLKPYTTFADMNSDPSIAEAL
EAMYGHPDNVELYPGLLAEETKKPMEPGSGLCPGFTTSFAIMSDAVALVRGDRFYTVDYSPSNLTSFGYTEVSSDFDVAG
GGMMYKLLMRAFPGWYRANSVYALYPFTTPEANFEVFKKLGTSQDFDFNKPSFIGPPTPITSWQGVVDVLSDQEHFHVPC
EISLRNSNLSAEAHNSAGGNHTFQLTHHDYMLSGDTPTNTEQRGFVKQCLYSPESGLEEVRHFYESITAELFRQHSRKVG
ESYQVDIEYGAGSDSYTARALSDVLANLFGYVFLDLDTAASYKNRVVAAAETKSLGEKMQTTVAGIKAQRFPSLRHMLRI
ASSDGVLRSYGVELIDRLLESGKGVDEAVWTIIPTAAAACATQAQGYYSHWPAIQKLAMSDEPEAFEKLKKYALEGFRLS
TPAFGLLRTVVADKADLRDGPRVVSVKKGDTIFTDFVTAGLDATKFPDPYEIKLDRPDDLYIHHGWGPHACLGRPIVTVA
GASMLRVCARLGNLRRAPGQAGEMKSKRVNDAFKVYLAENGSKWGPFPVSKKVVFDKTTEM
>CYP6002A3 Aspergillus clavatus
42% to CYP6001A2 (over full length)
up to 71% to 6002A1 in parts
ACLA_078500
MTSLIETSTTGGDKKPHNFLNDARQDLVSQAGRIVPNLKTVQELVQTVLNGGLMDDRRFLIENIIQ
VAASLPNTSNARDKITDTFVRTLWDTLQHPPLSYLGDQFKYRAADGSYNNIM
YPHLGAAGSYYARTVTPQHPRPAVLPDPALNFDTLLAREGPA
REHPSKISSNLFYLATLIIHDLFHTDEHD
GTKLKNSSYLDLGPLYGHNQ
EQQDQVRTFNNGLLKPDTFAEKRLLSQPPGV
CALLVAFNRFHNWVVGELASINEGGRFSLPPGMKSDDPACANAQKKRDNDLFQTGRL
(2)
ITCGLYVNIILNDYLRTILNLNE
NPVNSDWKLDPRKSIDVFDKGGFPRGVGNQVSAEFNMIYRWHAAINNQDEAWVNDLCRKIFGPSVDASKLSVSDFLDGLR
RYFRDSAPDGPSLWTFGGLKRRKDGRFADSDIVRLLQEGCDNVA
GAFGARNTPKVIKAIEMLGIQQGRQWGLATLNEFRTFFKLKPYSTF
EEVNSDPSVAGALEGLYGHPDNIELYVGIQAEEAKKPFLPGSGLCPGFTISAAILSDAVALVRGDRFYTV
DYSPANLTSFGFNVADSDSNVAGGGVMYKLLMKAFPGWYQSNSVYALYPFTTPGKTREIMDRYGNIKDLDFGKPSYMPSP
VMATTWAGVTKLLEDQRVCPLWGQRIFQVAGHGSALSEQVSLQEAQRRFITECFEDSEDALEKVRKTYEVIITDLLGEHS
RRLGDTYQVDVVRDVTNLAHAYFCARFFRIPLTEPNNPSPDAYTPRELSDTLSLLFGHIFLDLDPSESSQKRAKATKEGQ
RMGAIMAKVVATAEDNLVNRVLQALVRGTARSPVTTYGTQLIKQLLRGGKSIDEVVWMIIPTAAAMCASQAQMWAHMVDL
YLSDEYISHWPAIQELSRSDAPEAFDVLKKYALEGFRLSPVFGVLRTAVDKTSIMDGGEIRTVEKNTTVFADVAAANRDA
SRFRDPLKIRLDRPADVYIHRGWEPHASLGSMISCTAGAVLLRVLGRMGNVRRAPGPAGEIRSRLVDGRVRVYLREDGTD
WTHFPQNQKILFDRFA*
>CYP6002A4 Neosartorya fischeri
71% to CYP6002A3 Aspergillus clavatus
NFIA_045180
Note: this seq does not have an ortholog in A.
fumigatus
MAPPTESSSHSAGQNGKQRMFLIDARQDLLSQAGRILPDLRTIHELGQTAFNGGLVDDRKYLIENIIQVTASLPNTSALR
GKITDAFVSTLWDNLQHPPLSYLGDQFKYRTADGSYNNIMYPHLGASGSHYARTVTPQHPRPAVLPDPSLIFDTLLARDG
PAKEHPSKISSTLFYLATVIIHDLFHTDECDGTKVKNSSYLDLGPLYGHNQDQQNKVRTFTDGLLEPDTFAEKRLLTQPP
GVGALLVAFNRFHNWVVGELAYINEAGRFSLPAGVNQDDPRYSSAVAQRDNDLFQTGRLITCGLYVNIILNDYLRTILNL
NENLTQSDWTLDPRKSLEVFDKGGVPRGVGNQVSVEFNMIYRWHAAISNQDEAWANSLCQRIFGPEVDGSTLSVNQFLDG
LRKYFEDNVPGEPPTWTFGGLERQQDGRFADSDLVRLISDGCENVAGAFGARNIPKVMKAIEMLGIEQGRQWQLATLNEL
RAFFKLKPYSSFLEVNSNPAIAEALEALYGHPDNIELYVGIQAEEAKKPFYPGSGLCPGFTISTAILSDAVALVRGDRFY
TVDYSPANLTNFGFNAVSSDFDVAGGGVMYKLLMRAFPGWYRPNSVYALYPFVTPEKSREIMDKYMKFKDLNFDRPSYTP
PPVPVTTWEGATTVLENQKRFHVPWGTHTFQITGHDYMLSGDSAANAEQRRFVNECLYEPKTVLEVVRKLYESITTALLH
EKAFKLRDYYHVDIVGD ()
VGNLAHAHFCSQFFNIPLKDDKDPSPDAYTPRELSDALSLLFGYVFLDLEPTDSLRNRIAAAA
EEQRMGAIMAKSVSSARHSVVRRFMQALGRSEAGPGSYGQQLANRLLREGKSVDEVVWTIIPTAAAACATQAQGWAQMLD
LYLSDKYASHWPAIQKLARSADPAAFEKLKKYALEGFRLSTPAFGVLRTAVEEATIKDGEATTTVHEGDTIFVDFITAGR
DPVKFPDPDEIRLDRPADSYIHHGWGPHACLGRAIVTTAGAALLRVLGRLENIRRAPGPAGEMKSKMVNNAFKLYLRENG
SSWTPFPQNMKVIFDSFK*
>CYP6002A5 Aspergillus terreus
65% to CYP6002A4 Neosartorya fischeri
ATEG_00985.1
MTYNDRREPNGPSGNLSKLTKLVTGLRQDISSQTGRILPDLEVLQGIGSTIIAGGIIDDRKYLIERIIQVAASLPDNSRL
RDDITNELVKTLWNSLQHPPVSSLGNEFKYRTADGMSQNIMYPHLGAAGSPYARTVTPQHPRPSVLPDPSVIFD
(1)
TLLARKGPAKEHPTRVSSTLFYLATIIIH (1)
DLFHTDESDMNRLKNSSYLDLGPLYGHNQEQQNRVRTFKDGLLKDDTFSESRLLGQPPGVCALIIAFNRFHNYVVKEMAFINEAGR
FSLPTGLTPDSPEYLSALSKRDNDLFQTGRL (2)
VTCSLYVNIILGDYLRTILNLNANPVNSNWKLDPRGQIDFFDSEGVPRGLGNQ
VSAEFNMIYRWHAAISNQDEAWANAFMKDLFGQDVDPSTLSVTEFLRGLGKWSANLDKEPSRWTFGTLERLPTGSFKDSD
LVKILQDGTEHVAGAFGARNTPQVLKAIEMLGIQQGRDWGLATLNELRSYFKLKPYTTFEAVNSDPAIAEALEALYGHPD
NIELYVGVQAEESKVPFSPGSGLCPGFTISVAILSDAVALVRGDRFYTVDYGPVNLTTFGFKESNSDFDVANGGAMYKLL
MRAFPRYYAPNSVYALYPFTTPQQVRESFGKQAASGDLDYNVPSFQGPVTAIKSWEGVTHVLNQQKHFHVPWGSHTFQLT
HHDYMLSGDSTADANQRLFVDKCLYTPKDALDEVRRFYEDATSRLLQKYSRKLGPYYQVDVVRDIGNLVHAEFTSEFFDI
PLCADADRMDRDSYTTTELYDVLASLFGYVFLDVDVMQSFKHRVAASKYTEKLGKVMQKRIGHVTTHNSHLREYLIGSKS
KQKLLPDYGTELVRRLSAGGKSAEEVTWTIIPTAAAACATQAQG (0)
WAQLIDLYLSDKYYVHWP
DIQRLARSNDAESFEKLKKYALEGFRLSTPAFGVLREVTKDSTIEDGVEQVNLKRGDTLFVDFVTAGRDITKFPDPESIR
LDRPDDLYIHHGWGPHSCLGRPVVTVAAAAMLRVVARLDNFRRAPGPVGEMKNKVVAPGFKVYLPEDGSEWTPFPCNKKA
LFDSI
>CYP6002A6
Mycosphaerella graminicola MgPOSS11.41.1
52% to CYP6002A4 Neosartorya fischeri
MSFTNGHSDDVPTVKQTVHNYIKDVKSQLERLPEDATVVKSFVSALLTEGVTDDRKYLLENLIKWAASYPKDSPTGALLTNTMLATLWDNLKHPPLSYLGDQWRYRTADGSHNNILYPDL
GKSGSYYARSVVPERSPPAALPDPGDIFDALFARKGLAKEHPTQFSSIAISLATIIIHDVMRTDDLDPNKVASSSYLDLGPLYGHNQDMQNKVRTFKDGKLKPDTFAEPRILGQPPGVGALLVS
FGRFHNYVVEQLAEINENGRFNGMTDYAAARGLSEEAVTKKRDNDLFQTGRLITCGLYVNIILRDYVRVILNLNRADTAWTLDPRTDEFNPFDADGIPRGIGNQVSMEFNLIYRWHATVSNA
NEQWVNDFFAKIFPGKDPATITQAELVEGFKAWGHSLDADPSKWTFGGLQRNSAGGFDDGALVDILARTTEDVAGAFGARNVPVALRAIEILGINQGRNWGAASLNEARKFFKLKPHETFL
EINPDPDVAAALQALYEHPDNVELYPGLVCEDTKPPMVPGSGLCAGLTMAKAILSDAVALVRGDRYYTIDNSPANLTSFGFAEIASDPNVGFGTTINKLLIRAYPGWYRSNSVYALFPLTIPPE
NRAIFQARGIENDYTYDAPRFVPPPVPVTTWQGVVDVLENTKDFKVTAGPHVYELIKHDWMLSGDKTWNAEQKKTCLHALYDVPNGLAQIRDFYGTVTDSLIKSKSIKLRDRYQIDLVRDV
AIPSHAIVTAHIFRIPLDNSGGTLTATELYEAMATVFQYTFLDIDTAKTLAIKAAAKLAVTKLATAVSASCTEVSNGNLSFLESIFMKRDKGDVALPDYGTKLVQRLFDAGMSLDEVIWTIVPT
AAAAAPIQSQGIARLLDFYLSPEQEVHWAAIQELASSDSAESLEKLRKYALEGFRLSPAAAGALRRVASTNATIHDGDKSLHPPSGSSVFADFNTAGLDPAVFPDPEHIKLDRDDKLYIHHGW
GGHQCLGRDVVMGAMAVQLRAFARLKNLRRANGPAGELKSKVVNGAFRVYMNQDWSGWTPFPSTWKLYYDA
>CYP6003A1 Gibberella zeae
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XP_382844, 87% to CYP6003A2 Fusarium
verticillioides
MSFNEKYQAG ESYKDTSKED PSSLLDNPEK
LVADLMKDFA GVRSQASPAD LLALVKQLLS
61 KGQPLDDKKG VRTTELLIGI LTALPRSSKA RTALTNKLID TLWGNLQHPP LSYVGGDVKY
121 EVAGAEPDHK SHCAQYDTIE FQVPGTNVTL KEQVPQAPDG LHQYRMPDGS
FNNILEPNLG
181 KAGTPYAKSV RTEKRLHGVK PDPGLLFDLL MARDEGSFKE NPAGISSMLF
YHAAIIIHDI
241 FRTNRTDMNK SDTSSYLDLA PLYGSSLKDQ LEIRTMKEGK LKPDTFHEKR
LLGQPAGVNV
301 MLVLYSRFHN YVADILLKIN ENGRFSMSTP PNATEEEKAK AIAKQDHDLF
NVARLITGGL
361 YINICLHDYL RAITNTHHSA SDWTLDPRVA IDKQFDGEGV PRGVGNQVSV
EFNLLYRFHS
421 CISKRDERWI NGFFLKLFPG RKAEDLQDVS WTELGQALMT FEANTPKDPS
VRTFDGLERQ
481 ADGTFKDEDL VNILKTAMED PAGCFGARMV PKALKVVEVL GIIQGRKWQC
ASLNEFREFF
541 GLKRYNQFSD INSDPEIANI LEKLYTDPDM VELYPGLMVE DIKPQRNPGS
GIMPTYSVGR
601 AVLSDAITLV RSDRFNTIDY TVSNLTSWGY NEVQQDYKTL GGSMLYKLIQ
RGVPNWFPYN
661 SVAVMQPMYT KSANEKIAKE IGTFDQFTTD DPKPPAKVAV TMSNETIKKV
LSNTKQYVVP
721 WLKPLNDLFP GKKEYGWFML AGDEAKNYQH RADWTKALKK VPNLHDAVHT
FIEREGARLI
781 KKESFTFKKG LDQIDIIRDV AIPLNAQLLS DMFYFDMRTD ENPDGELGAA
ELYRSLLDIR
841 VWGVNNNDPG QAWNRRRRAQ EGVKRIYDST KKLVSEVEVA RPRGIGLISA
VSNRIGAKSY
901 LKKDSLRSCG LKLVEELLAQ GSSIDHVTDN LWLTAFGGIG VPVTAFYEVL
AFFLRPENAS
961 IWAEVQAIAQ KGDDATLHAY VAEALRMTSS QRNVRISKTP GEVDGQSIAP
GTAVVLMLGE
1021 AGRNPKEIPD ADKFNAQRKQ QEVSAFSYGQ
HECVAKDVAL AFVTGLIKLV ADLKELRPAP
1081 GQMGTVKTIR VGTEKAYLND SWSYLGFDAS
TWKVHFNGHG KGNFEGDRVP TSNTPIQEYY
1141 SLLQKRKDEL LRR
>CYP6003A1 Fusarium oxysporum
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
Fox10645
Ortholog to CYP6003A1
Gibberella zeae
Name revised from CYP6003A2
MSFNEKFQAGESYGDSKEDPSSLLNNPEKLVADLMKDFAGVRSQASPAQLLGLVKELLQKGQPLDDKKGTTELLIGILTA
LPATSKARTALTNKLIDTLWGNLQHPPLSYMGGDVKYDVVNSDKPAHKHNCELYDTIEFKVPGTDVLLREQVPQAPDGLH
QYRMPDGSFNNILEPNLGRAGTPYAKSVKSEKRLHGVKPDPGLLFDLLMARDETTFQENPAGISSMLFYHAAIIIHDIFR
TNRTDMNKSDTSSYLDLAPLYGSSLKDQHEIRTMKEGKLKPDTFHEKRLLGQPAGVNVMLVLYSRFHNYVADILLKINEN
GRFSLSVPPNASEEDKAKAIAKQDHDLFNVARLITGGLYINICLHDYLRAITNTHHSASDWTLDPRVAIDKQFDGDGVPR
GVGNQVSVEFNLLYRFHSCISKRDEKWINNFFLKLFPGRKAEDLQDVSWTELGQALLTFEQNTPKDPSVRTFDGLERQAD
GTFKDEDLVRILKDAMEDPAGTFGARMVPKALKVVEVLGIIQGRKWQCASLNEFREFFGLKRYDSFSEINSNPDIANILE
KLYTDPDMVELYPGLMIEDIKPQRNPGSGIMPTYSVGRAVLSDAVTLVRSDRFNTIDYTVSNLTAWGYNEVQQDYKTLGG
SMLYKLIQRGVPNWFPFNSIAVMQPMYTKKANEQIAKEIGTFDQYTLDDPKAPPKVAVLTSGPAIKQILSNTKQYVVPWL
KPLNTLFPGKKDFGWFMLAGDQPQNYTHRANFSKAMSKIPNMHNAVHAFIEREGTKLINKETFTLKKGLDQIDIIRDVAI
PLNTQLLADLFYFDLRTDENPDGKLGVAELYRSLLDIRVWGVNNNDPAQAWNRRRRAQEGAKRMIETTKTIVAEADAGRP
RGIGLVSAVANRIGARSYLKKDSLRSCGLKLVEELLAQGNNVDQVTDNLWLTAFGGIGVPVTAFYEVLSFFLRPENEAIW
AEVQAIAQKGDDATLHAYVAEAQRMTSSQRNVRVATAPGEVQGQAIQPGTAVVLMLGEAGRNPKEVPDAGKFNPQRKKED
VSAFSYGQHECIAKDVALAFVTGLIKLVADLKELRPAPGQMGTVKTIQVGTEKAYLNDSWSYLGFDASTWKVHFNGHGKG
KFEGERVPTKSTPIQEYYYLLQKRKDEILGN
>CYP6003A1 Fusarium verticillioides
98% to CYP6003A2 Fusarium oxysporum ortholog
FVEG_09294
Name revised from CYP6003A2
MSFNEKFQAGESYGDSKEDPASLLNNPEKLVADLMKDYAGVRSQASPAQLLGLVKELLQKGQPLDDKKGTTELLIGILTA
LPASSKARTALTNKLIDTLWGNLQHPPLSYVGGDVKYDVVNSDKPAHKHNCELYDTIEFKVPGTDVLLREQVPQAPDGLH
QYRMPDGSFNNILEPNLGRAGTPYAKSVKSEKRLHGVKPDPGLLFDLLMARDETTFQENPAGISSMLFYHAAIIIHDIFR
TNRTDMNKSDTSSYLDLAPLYGSSLKDQLEIRTMKEGKLKPDTFHEKRLLGQPAGVNVMLVLYSRFHNYVADILLKINEN
GRFSMSVPPNASEEEKAKAIAKQDHDLFNVARLITGGLYINICLHDYLRAITNTHHSASDWTLDPRVAIDKQFDGDGVPR
GVGNQVSVEFNLLYRFHSCISKRDEKWINNFFLKLFPGRKAEDLQDVSWTELGQALLTFEQNTPKDPSVRTFDGLERQAD
GTFKDEDLVRILKDAMEDPAGTFGARMVPKALKVVEVLGIIQGRKWQCASLNEFREFFGLKRYDSFSDINSNPDIANILE
KLYTDPDMVELYPGLMIEDIKPQRNPGSGIMPTYSVGRAVLSDAVTLVRSDRFNTIDYTVSNLTAWGYNEVQQDYKTLGG
SMLYKLIQRGVPNWFPFNSIAVMQPMYTKKANEQIAKEIGTFDQYTLDDPKTPPKVAVLTSGPAIKQILSNTKQYVTPWL
KPLNTLFPGKKDFGWFMLAGDQPQNYSHRANFAKAMSKIPNMHNAVHAFIEREGTKLINKETFTLKKGLDQIDIIRDVAI
PLNTQLLADLFYFDLRTDENPDGKLGVAELYRSLLDIRVWGVNNNDPAQAWNRRRRAQEGAKRMIETTKTIVAEADAGRS
RGIGLVNAVANRIGARSYLKKDSLRSCGLKLVEELLAQGNNVDQVTDNLWLTAFGGIGVPVTAFYEVLSFFLRPENEAIW
AEVQAIAQKGDDATLHAYVAEAQRMTSSQRNVRVATAPGEVQGQTIQPGTAVVLMLGEAGRNPKEVPDAGKFNPQRKKED
VSAFSYGQHECIAKDVALAFVTGLIKLVADLKELRPAPGQMGTVKTIQVGTEKAYLNDSWSYLGFDASTWKVHFNGHGKG
KFEGERVPTKSTPIQEYYYLLQKRKDEILGK*
>CYP6003A1 Nectria haematococca (Fusarium
solani f. batatas)
84% to CYP6003A2 Fusarium oxysporum = ortholog
estExt_Genewise1Plus.C_sca_20_chr6_4_01131
name revised from CYP6003A2
MSFNEKFQAGESYGDARTGSTSLLDDPIKLATDIIKEYGGIRSQASIPELAELIKELTIEKGKPLDDKKGTTELLIGILT
SLPRTSKARTQLTNKLIDTLWGNLQHPPLSYVGGDVKYEVVNSNEPAHKHNCELYDTIEFKAPDSDVILREQVPQAPDGL
HQYRMPDGSFNNILEPNLGRAGTPYAKSVRSEKRLHGVKPDPGLLFDLLLARDDKNFTENPAGISSMLFYHAAIIIHDIF
RTSRTDPNKSDTSSYLDLAPLYGSSLKDQLEIRTMKEGKLKPDTFHEKRLLGQPAGVNVMLVLYSRFHNYVADILLKINE
NGRFTLQCPANASAEDKAKAVAKQDHDLFNVARLITGGLYINICLHDYLRAITNTHHSKSDWTLDPRVAIDKQFDGEGVP
RGVGNQVSVEFNLLYRFHSCISKRDEGWINNFFLKLFPGRKAEDLQDVSWNELGQALFNFERSIPKDPSVRTFDGLQRQE
NGTFKDEDLVRILKDAMEDPAGTFGARMVPKALKVVEVLGIIQGRKWQVASLNEFREFFGLKKYDQFSEINSNPEIANIL
EKLYTDPDMVELYPGLMIEDIKPARNPGSGIMPTYSVGRAVLSDAVTLVRSDRFNTIDYTVSNLTAWGYNEVQQDYKTLG
GSMLYKLIQRGVPNWFPFNSVAVMQPMYTKKANIAIAKEIGTYDQFSEADPKPPAKPIVVTTNEAIKKTLSNPKQFVVPW
LQALNTLFPGKKDYGWFMLAGDEAKNFKHRADFQKAMGKIPNLHAAVHNMIERVGAKLIEKETFKLKAGLEQIDIIRDVA
IPLNTQLLADLFYFDLRTDENPDGTLGVAELYRHLLNIRVWGVNNNDPGQAWNRRRWAQEGVTAVYNSSKKLVDEAVLGR
GMGLGIASAISSKVGRKSYLKKDSLRSCGLKLVEELLAQGNNADQVTDNMWLTAFGGIGVPVTSFYEVLAFFLRPENAAV
WAEVQAIAQKGDDATLHAYVTEAQRLTSSQRNVRIATAPAELEGKPVQPGTPVVMMLGMAGRNDKEVPDAGKFDAQRKTD
AVTAFSYGQHECIAKDMALAYVTGLIKLVADLKQLRPAPGQMGEVKTIQVGTEKAYLNDSWSYLGFDASTWKVHFDGHGK
GTFEGDRAPTATTPLQQYYYMLQKRKEEILG*
>CYP6003B1 Aspergillus oryzae RIB40
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001727759.1 revised 3/17/2009
MGWLSTTTKSSWNPFSTGSSGSSLDSGGSLASLAFGSKDQKWFQ
SVLSKFGFNGVLATVLSFFLYALYLKFVSHDEKGLQTLIKEKASQYLGKIPGLNKLSF
LKGHLPLGKFSKSLIPKATKGALGSIAGSSGGILSKLNPFNWKIFNKRKIAEEEDDMR
YQAGEPYGDPEVLAPTLRDDLKAVGLKAGVQDLKVLLDVVKNKGKPIDDRDLTMEKLI
AIVSSLPRNSKAREKLTGVLIDTLWQSLPHPPMTYLGNKYQYRTPDGSYNNPLQPDLG
KAGSPYARNVPKLKHMHGVPPDPGLLFDLLMARSDETFKENPAGLSSVLFYHATIIIH
DIFRSNRFDPNISDTSSYLDLAPLYGSSLEDQMKVRTKVRGLLKPDTFSEKRLIGMPP
GVNAILVMYNRFHNYVADNLLKINEGGRFSLPATKSEEDKKAALAKQDEDLFQTARLV
TNGLYVNISLHDYIRGLANVHHSSSDWTLDPRVKINKIFDSEGVPRGIGNQVSVEFNL
LYRFHSIISRRDEKWMNEFFADIFGQDKKVDQLTPQEFIQGLYRFEQSIPEDPSEREF
GGLKRGENGKFSDADLVQLMKDSMEDPAGCFGARMVPKALRVIEILGIIQARKWQLAS
LNETRDFFKLKRHETFEDVNSNHEIADLLRKLYDDPDMVEMYPGL
FLEDIKPRMDPGHGGCTPYTVGR
AVFSDAVTLVRSDRFLTIDYTASNLTCWGYNEVQQDYDILGGSMFHKLFQRALPNWFP
YNSLHITQPMYTRKMNEQIAREIGTIDEYTLDDPSPPPKTVIVTKHSTITKLSKDQAN
FRVIWAKYLNEMIPGRDFSGYMLLGDKPANTDQKTLVKEILYSPAEFVQLLSETAVSV
AKEQLATETLNLTSELHQVDIVRDVAIPMVTRILADLFCLDLKTPENPNGTYNVAELY
KYIIDVRIFGFNNDDPGLALQRRKWAREGAESLTKTTLRVVSNLPASEKSGKGIVKGA
VSTAKSIASKIPLVGKLVGDGKGVEGQSTSGSLRWYGYNVAKELIASGKTPAEVADIS
WMNAVGGVGATIGVFTDVLNYFLQDENSHHWEEIQKLAASSDLESSNKSLRQYVLEAQ
RLTSTQRSIRLCAGKAVIDGQSFEPGNLVICLLGAACKDPDAVPDPEAFKLDRPSSAY
IHFNVGPHECLGREIALSCITSLVRVCAGLKNLRAAPGQMGVLKSITTGTEKHFLNDS
WSTLTVDPTTWKIHFEGQGQGIHHPPKIPVTAGRDLNALSNALKKQHQDKLQETVSKV
ANGVTAPLTKLIPSNGPSNGASTPGHLPLPINPFQNGNGNSNGVANGNTHPSLLHQAV
SSAAAIPQHALGTVHDVAHNTVGHLPGGQQVTDFTHGLVHPFAGAVSPGQTQTPPQGQ
TQPHQGNWFFLPHGMENAAKQVPGHLFGQTA
>CYP6003B1 Aspergillus flavus
99% to CYP6003B1 Aspergillus oryzae
AFL2G_03725
MGWLSTTTKSSWNPFSTGSSGSSLDSGGSLASLAFGSKDQKWFQSVLSKFGFNGVLATVLSFFLYALYLKFVNHDEKGLQ
TLIKEKASQYLGKIPGLNKLSFLKGHLPLGKFSKSLIPKATKGALGSIAGSSGGILSKLNPFNWKIFNKRKIAEEEDDMR
YQAGEPYGDPEVLAPTLRDDLKAVGLKAGVQDLKVLLDVVKNKGKPIDDRDLTMEKLIAIVSSLPRNSKAREKLTGVLID
TLWQSLPHPPMTYLGNKYQYRTPDGSYNNPLQPDLGKAGSPYARNVPKLKHMHGVPPDPGLLFDLLMARSDETFKENPAG
LSSVLFYHATIIIHDIFRSNRFDPNISDTSSYLDLAPLYGSSLEDQMKVRTKVRGLLKPDTFSEKRLIGMPPGVNAILVM
YNRFHNYVADNLLKINEGGRFSLPATKSEEDKKAALAKQDEDLFQTARLVTNGLYVNISLHDYIRGLANLHHSSSDWTLD
PRVKINKIFDSEGVPRGIGNQVSVEFNLLYRFHSIISRRDEKWMNEFFADIFGQDKKVDQLTPQEFIQGLYRFEQSIPED
PSEREFGGLKRGENGKFSDADLVQLMKDSMEDPAGCFGARMVPKALRVIEILGIIQARKWQLASLNETRDFFKLKRHETF
EDVNSNHEIADLLRKLYDDPDMVEMYPGLFLEDIKPRMDPGHGGCTPYTVGRAVFSDAVTLVRSDRFLTIDYTASNLTCW
GYNEVQQDYDILGGSMFHKLFQRALPNWFPYNSLHITQPMYTRKMNEQIAREIGTIDEYTLDDPSPPPKTVIVTKHSTIT
KLSKDQANFRVIWAKYLNEMIPGRDFSDYMLLGDKPANTAQKTLVKEILYSPAEFVQLLSETAVSVAKEQLATETLNLTS
ELHQVDIVRDVAIPMVTRILADLFCLDLKTPENPNGTYNVAELYKYIIDVRIFGFNNDDPGLALQRRKWAREGAESLTKT
TLKVVSNLPASEKSGKGIVKGAVSTAKSIASKIPLVGKLVGDGKGVEGQSTSGSLRWYGYNVAKELIASGKTPAEVADIS
WMNAVGGVGATIGVFTDVLNYFLQDENSHHWEEIQKLAASSDLESSNKSLRQYVLEAQRLTSTQRSIRLCAGKAVIDGQS
FEPGNLVICLLGAACKDPDAVPDPEAFKLDRPSSAYIHFNVGPHECLGREIALSCITSLVRVCAGLKNLRAAPGQMGVLK
SITTGTEKHFLNDSWSTLTVDPTTWKIHFEGQGQGIHHPPKIPVTAGRDLNALSNALKKQHQDKLQETVSKVANGVTAPL
TKLIPSNGPSNGASTPGHLPLPINPFQNGNGNSNGVANGNTHPSLLHQAVSSAAAIPQHALGTVHDVAHNTVGHLPGGQQ
VTDFTHGLVHPFAGAVSPGQTQTPPQGQTQPHQGNWFFLPHGMENAAKQVPGHPFGQTA*
>CYP6003B2 Aspergillus terreus NIH2624
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001211214.1
ATEG_02036
MSSVIVALAVLVLSLLYLTLFRNDLTHLIIEKLQSFRTGSGWEL
SPRSRLLPRATKAALSSITGTGVGIWSRLYARIFHSDELAEEEDDEKYQAGEAYGDPK
VLATSLIKDLRALGVKGRRSDLRTLIEMVKNKGKPMDDRQMHMEKIIAIVAMLPRTSK
ARQRLTGVLIDQLWRSLQHPPLSYFGNKYQYRTPDGSYNNPLEPNLGKAGSPYARSIP
RIKTMHGVRPDPGLLFDLLMARDDSTFKENPAGISSMLFYHASIIIHDIFRTNRRDPN
ISDTSSYLDLAPLYGSSLEDQLKVRTMEKGMLKPDTFHEKRLLGQPAGVNVILVMYSR
FHNYVADMLLKINENGRFTLPPTSSEEARKKALAKQDEDLFQVARLVVNGLYVNISLH
DYLRGLTNTHHSASDWTLDPRIAVGRTFDPDGVPRGIGNQISAEFNLLYRFHSVISRR
DEKWTNEFLKSLFPDLNKPLDQLTPQEFMMGLMRYEQSIDKDPSKREFGGLKRSPDGK
FNDADLVQILKDSMEDPAGLFGPRNVPKALRMIEIAGIMSARKWDLGSLNEMRDFFKL
KRHATFEDINPDPEIADLLRKLYDHPDMVEMYPGMFLEDAKPRLDPGCGGCPPYTVGR
AVFSDAVTLVRSDRFLTLDYTASNLTNWGFREVQQDYDILGGSMFHKLIQRALPGWFP
YNSLHATQPMFTRKMNEQIAREIGTIDHYSLADPAPPPRKIVLTDYATNIKVLKDQAS
FRVPWARYLNDMFPGKTYNDYMLGGDDPANAAQKKLVHSILFSPDQFLDLLSETTTKL
GSELLKANTLWLTKDLHQVDIIRDVAIPLNARIMADLFCLDMKTPENPTGSMNAATVY
RHLMNVRIWGFNNNDPALMLQRRKWAIESAEALIETTRKLVNEQAQPAQSGVLKNLMT
RRQATGTLRWYGNNVAKEMMEMGMSAEEVADICWLTAIGGVGTPSGVVANVLQYYFRY
ENIGHWEEIQKLVTQPDTPAADRTLRQYVLEANRLTSMECTVRVCARPVTVDGHDFKP
GEVIVNHLGLACRDPHNIPDADKFRLDRPASAYIQWGYGAHECLGKEIAITFAVSMIR
ILAGLKYLRPAPGEMGVLKSVMADGRQAFLNDSWSWLTQDPTSKSNMHGKASAVD
>CYP6003B3 Aspergillus niger CBS 513.88
fusion with diooxygenase, P450 (C-term) part may act like
a hydroperoxide isomerase
XM_001395183.1 (An12g01320)
MGSIFAALLLCLLSYLYLRVFADDLTRPFQILAKFFSSHQHPAW
KLRPRFLPKATRAALSSIAGTGEGLWQRLYARTFHAQELAEVEDDVKYQAGEPYGDPD
VLATGLVKDLSALGLKGKRNDLRTLIQLVKAKGKPIDDRQMLMEKVIAIVSMLPRTSK
SRQRLTGILIDQLWQSLEHPPLSYFGNKYQYRTPDGSYNNPLEPDLGKAGSPYARSVP
RLKALHGVQPDPGLLFDLLMARDDTTFRENPAGISSVLFYHASIIIHDVFCTNRRDPN
ISDTSSYLDLAPLYGSSYEDQLRVRTMQRGMLKPDTFHEKRLLGQPPGVNVILVMYNR
FHNYVADVLLKINENGRFTLPPTTSEDAKRKALAKQDEDLFQVTRLIVNGLYVNISLH
DYLRGLTNTHHSASDWTLDPRVAVSRAFDADGVPRGVGNQVSAEFNLLYRFHSVISRR
DEQWTNEFLKSLFPDLKKPLEQLTPQELMQGLINYERSIDKDPSKREFGGLKRNQDGR
FNDAELVQILKDSMEDPAGLFGARMVPKALRMVEIAGILTARKWNLASLNEMRDFFKL
KRHSSFEDINPDPNIADLLRKLYDHPDMVEMYPGIFLEDAKPAMDPGCGGCPPYTVGR
AVFSDAVTLVRSDRFLTLDYTASNLTNWGIREVQQDYDILGGSMFHKLIQRALPGWFP
YNSLHATQPMFTRKMNEQIAKEIGTIDRYSQEDPKPPPRTVMLANHATIIEVLKDQDT
FRVPWARYLNDMIPGKRFNDYMLGGDGPVNAAQKKLVKSILFSPDQFNQLLSQTTVRL
GKELLELNALQLSKDLNQVDIIRDVAIPLNARIMADLFCLDMKTPENESGSMNAATVY
KHLMNVRTWGFNNTDPGLMLQRRKWASESAEALVKTTLKVVNEQAQPQKTRMLGKLTG
YQQSEVSTLRWYGNNVVKQMMEMDMTAAGTAEVCWLTAVGGVGAPVGLIADVLQYYLR
PENIDHWKRIQNLVSQPDNSGSIDKLLRQYVLEAQRLTSMECTVRVCKAHRTINDQEF
KPGDVVITLLGPACRDPTSIPDAETFKLDRPSNAYIHFGYGAHECLGKEIGLTFAVSM
LRVLAGLKYLRPAPGDMGMLKSIIVDGRRVYLNDSWSWMTRDPTNGGIGMSTQYSFGQ
HHHHQYHEITRTSSSSLPSMLGDDESYGRFSGTLN
>CYP6003B4
Mycosphaerella graminicola MgPOSS40860
51% to CYP6003B2 Aspergillus terreus
MPNPLTEHPLFAGAAGLGAIAAAASLWSQKPPSPEVSTTEKYRPGDDYTDNAHLAVDVVKELRKAGVHSTFHDIKTLLTFAFTAATHQPVDDRELMMEKVIAVVTKLPQNSKARRKLTGILI
TGLWNSLDHPPLTFQGPEYQYRRADGSYNNILNPQLGAAKTPYAKSIRTEQKLNAARPDPGVLFDSLMARDDSQYEENPAGLSSMLFYHATIITHDIFRSSHTNPNISDTSSYLDLASLYGNSV
ADQKKIRAFEGGKLLPDTYFEERLLAQPPGVNVMLVLYSRYHNFVADMLSKINEGGRFNLKPVPADAEDPKMAAKAQDEDLFQTARLVVNGLYINVCLHDYLRALTNTHHSDSTWTLDPR
VEIPGSALKSETARGIGNQVSTEFNLMYRFHSVISQKDEKWFEEFFAKESKLKKPLSECTPREVLIALQKFEGTIDEDPSKRTFAGLQRGADGKFADADLARVLKECMDDTAGRFGPRHVPKS
LRAIEMMGINRARQWNTASLNEFRKFFGLKPHETFEDINPDPEIVNTLRGFYGHPDLVEAYPAMWLEDGKPRMDPGQGACVPYTVGRAIFSDAVTLVRSDRYYTIDYTAASLTNWGFTEVQ
QDLSTMGGSMMYKLIQRGLPGWFAFNSVAVMQPFFSKKMNAQIATELGTIGDFTQDDPKTPPKPKIVTKASTARKILTDSTNFVVPWGKAYRDLNDGHDYSHFMLSGDAPANVEQKKLMH
SLLFKSPDFKKLVSETTFRIADKHIKAEMFSMGKDFLDGKPKFEVDLVRDVAIPTLAELLSDIFCLGIKTDENPIGTYNAAGLTRDLLALRTWGFANFDPAQAWRRRREAREAADRLRTRVVA
HLKLVTGSSDGGLVSKAIGYLTGSSADHPPKANSLRWHGINTARQLLAAGNSYSKTAEILFLSALGGIGSPISQFTESYYWLTQSSSTGHAAAIQSLVSSNAPDLNDKLEKYILEAERMTSLGR
VARVVKSPVTVDGVSYSPSDAVILLMGVNGAAMDSDLHSNPSTFDLTRPRRNYLNGGYGSHECLGREISLSFSTALLHAATGLQLMTWAPGTGVLRPISAHNNRFYLSEDGAHLTSDPTTLK
CHFRAYTHDRGAFLPLPPIPKEIMPPSEGKVERGLRPSDIAEEKKYLIETGSTYTKEEIEVSYSANAPPGAIVFAGGDGGIQKAVRKEFVRMNTKINREEKREEGKTDFGHGHYHHHHN
Unnamed
>Alternaria
brassicicola DN479176.1 51%
to 65AH1
TRVTIPQCAINSSPRNFENPGAFIPERWLPGTGF
DKDIKEAMQAFGVGPRNCLGRNLAYMEIRMLIANLLWHFD
MELSDKSQNWLKQKTW
MMWERGPMFVYVTPRKK*
Note
fungal species have a fatty acid oxygenase PpoA like
protein that is a dioxygenase fused to a P450. It is found in
blast searches. Example XP_382844 Gibberella zeae
PH-1 (anamorph: Fusarium graminearum), also Fusarium oxysporum FOXG_10645, FOXG_16700, FOXG_16765, FOXG_12909
MSFNEKFQAGESYGDSKEDPSSLLNNPEKLVADLMKDFAGVRSQASPAQLLGLVKELLQKGQPLDDKKGTTELLIGILTA
LPATSKARTALTNKLIDTLWGNLQHPPLSYMGGDVKYDVVNSDKPAHKHNCELYDTIEFKVPGTDVLLREQVPQAPDGLH
QYRMPDGSFNNILEPNLGRAGTPYAKSVKSEKRLHGVKPDPGLLFDLLMARDETTFQENPAGISSMLFYHAAIIIHDIFR
TNRTDMNKSDTSSYLDLAPLYGSSLKDQHEIRTMKEGKLKPDTFHEKRLLGQPAGVNVMLVLYSRFHNYVADILLKINEN
GRFSLSVPPNASEEDKAKAIAKQDHDLFNVARLITGGLYINICLHDYLRAITNTHHSASDWTLDPRVAIDKQFDGDGVPR
GVGNQVSVEFNLLYRFHSCISKRDEKWINNFFLKLFPGRKAEDLQDVSWTELGQALLTFEQNTPKDPSVRTFDGLERQAD
GTFKDEDLVRILKDAMEDPAGTFGARMVPKALKVVEVLGIIQGRKWQCASLNEFREFFGLKRYDSFSEINSNPDIANILE
KLYTDPDMVELYPGLMIEDIKPQRNPGSGIMPTYSVGRAVLSDAVTLVRSDRFNTIDYTVSNLTAWGYNEVQQDYKTLGG
SMLYKLIQRGVPNWFPFNSIAVMQPMYTKKANEQIAKEIGTFDQYTLDDPKAPPKVAVLTSGPAIKQILSNTKQYVVPWL
KPLNTLFPGKKDFGWFMLAGDQPQNYTHRANFSKAMSKIPNMHNAVHAFIEREGTKLINKETFTLKKGLDQIDIIRDVAI
PLNTQLLADLFYFDLRTDENPDGKLGVAELYRSLLDIRVWGVNNNDPAQAWNRRRRAQEGAKRMIETTKTIVAEADAGRP
RGIGLVSAVANRIGARSYLKKDSLRSCGLKLVEELLAQGNNVDQVTDNLWLTAFGGIGVPVTAFYEVLSFFLRPENEAIW
AEVQAIAQKGDDATLHAYVAEAQRMTSSQRNVRVATAPGEVQGQAIQPGTAVVLMLGEAGRNPKEVPDAGKFNPQRKKED
VSAFSYGQHECIAKDVALAFVTGLIKLVADLKELRPAPGQMGTVKTIQVGTEKAYLNDSWSYLGFDASTWKVHFNGHGKG
KFEGERVPTKSTPIQEYYYLLQKRKDEILGN
>CYP6004A1
Mycosphaerella graminicola
MgPOSS60064
only 33% to CYP6001C16 Aspergillus terreus, no heme signature
yellow area resembles CYP6001C8 heme region
with D as CYS
MAVGQLKSLLGSIRRKPSTAPDRRSREETNGVNGEKTSLMSDLSSIGVKNVKMLGGALVDMAGGEPLDDKQLLLENGVSMLQSLPSNSGLGSTVSNGFIGMLWNDLPHPAATLAGPESRYR
RHDGGGNNPWQPEMGKAGTPYSRSVPPVKPKGPNLPDVELVFEQLLKRDGAFREHPSGLNRLFFSFATI
HECFQTSREHHWINETSSYVDLSTLYGNTEVEQKRVRTYNNG
TIYPDSIASERIMMMPPGVVAVLVMFSRNHNEIAQSLYTINEDGKYKPWDSLDKEQQV (?)
QDNDIFQLSRNINVGFFATVVLKDYVAAILNTPRANSEWSLDLGAEIKKGGS
RVERGTGNVVSTEFAVLYHWHAALSAADAQWMEDIIRESAPEIGHIDDVTAETFTKVVKTQGHKLMSTEPRLWTFGGIKRGADGRFSDNDLGEILKNCVDEPAHAFGAHGTPASLKVVDL
MGQLQARNHFKVCTMNEFRTYLNLKAYESFEDWNPDKKTARAAELLYGHIDNLELYPGLMAECTKPAMPGSGVCPGQTTGRGILDDAVALVRGDRFLSYDFNSNTLTNWGFAKLGSLPG
GSYGGMLPHLLFTGLPGAYKGTSPYALLPFYTPKAVAGILKGNKAIDRYDLNRNRSDGGIVAVHSQAGCKQVFEDEQTFR
PAFSMD
KTNFLPKVFFTDGFDGKITKYFSETVARLIKDSSLKY
AGSKRSVDIVRDVTNVAPIMWLAEHFAIPLKTARTPKGLLSLPQLFDMYMVTFLYQNFNILPINEWKLRDGYQKAEPVLRNIFETHLKTQQGFKETIVDRLAKGSAYEVGPEADRLYHALND
SKLPTRDLVTDCIGMGAPVAGIVTQQASLLIAFYLRPDNSQHKGRIVQLAHQNDAASESQLQGYVLEGMRHAGVVPGLPRVATKDVVVEDGANGSVRIKRDQTVLIATSSSSKDASAFADP
DTIDPSRPRESYFMLRSGLHADFGSKLVLPALAATLREVFKLKNVRAAPGKNGMFTTTRH
VVAGVVLTHYLDDNARESPFPTSLTVEYDE
>CYP6004A2 Mycosphaerella fijiensis
65% to CYP6004A1
32% to CYP6001A1
e_gw1.1.1178.1
MPGKLSRVIGTIKRKPTTAPDRKDDQEAALAPSQRKTSAIHDLIHL (0)
DMKDKKVIASGLTGLASGEPMDDKELLLENGVSM
LQGLPLNSGLSAATSDAFITMLYHDLPHPPTTMAGPTSRYRRHDGGNNNPWNPEMGKAGTPYSRSVPPSKPKGPNLPDPE
LVFEQLMKREDGNFRKHPSGLNRLFFSFATIVIHECFQTSREDPWINETSSYV
DLSTLYGNTKNEQKRVRTYQQG
RIWN DSMASERIMLMPPGVVALLVMFSRNHNSIVESLLTINEAGKYKPWDQLNEEQKVW (2)
QDEDLFQLGRNINVGFFASVVLKDYVAAILNTPRADSTWSLDLGKEIKKS
GQRIERGTGNVVSTEFAVLYHWHAALSAADAQWMEGVLRANLPELKSVDDMTVEMFYKVMYQEGHKLRDTLPREWTFNGL
KRAPDGRFNDHELAELIKDCIEEPAHAFGAHGTPASLKVVDIMGQLQARELFNVCTMNEFRSYLNLKAYESFEEWNPDKK
VARAAELLYGHIDNLELYPGLMAECTKPPMPGSGVCPGQTTGRGILDDAVALVRGDRFLSYDFNSNTLTNWGLSKVGTSV
AGGAYGGVLPKLIMNGLPGAWTGTSLYALLQFYTPEAAQGIVKQHKAIGQYDTTRPRSDLDIVSVQTSAGCKQVSEDLTSFR
SIQPTATQTIANGNNFMLGSGDPK
KAASLQRIFFEDGFVASVRKYFETEVSKLIKASSLRYSNGKRSFDVVRDITNVT
PITWLAERLAIPLKTVAQPRGLISQPQLFEAYMAIFLYQNFNIIPAHEWTLRAGATQATALLTEVHSAHLSTQSGFKEHI
VDWLAKGSAFEVKPEADRIYKALIATKEPNDKLAGDCIGVAAPIAGILTHQASLLIDLYLRPGYEAYKARIIELSHKNDD
ASFKELQGFVFEGMRHAGVVPGLPRQATRDITVQDGVRGPVNVKKGNIVLIATSKEALDPTSFAEPEKLNPHRPLSEYTL
LGSGLSFGASLIGPAIAATLKEVFKLPGIRRANGKPGHLATVEHFVGGIPVRSYLDSNAKESPVPTTLVLEYDEAVAPLT
NGVNGVNGGANGVHSLYTPSQTLAGPQNGS