This file contains 556 P450 sequences from bacteria
Revised April 18, 2007 

>CYP51 Rv0764c Z80226 Mycobacterium tuberculosis
MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ
LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN
AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ
LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT
DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR
DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV
QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH
RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG
V

>CYP51 Mycobacterium avium
3021360 TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 3021539
3021540 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 3021719
3021720 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 3021899
3021900 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 3022079
3022080 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 3022259
3022260 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 3022439
3022440 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 3022619
3022620 PADSYRNDHSKMVVQLARPAKVRYRKR 3022700

>CYP51 Mycobacterium smegmatis TIGR contig:3439 
4858809 VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS 4858988
4858989 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV 4859168
4859169 ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 4859348
4859349 LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 4859528
4859529 VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 4859708
4859709 NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 4859888
4859889 DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 4860068
4860069 YRNDHSKMVVQLARPAKVRYRRR 4860137

>CYP51 Methylococcus capsulatus TIGR contig:221 
908332 MSHPPSNTP
908305 PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 908126
908125 DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 907946
907945 LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 907766
907765 NLPLPVFKRRDQARVRLQELVTQIMERRARSQERSTNVFQMLIDASYDDGSKLTPH 907598
907597 EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 907418
907417 PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 907238
907237 FDPDRYTPERAEDKDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE 907061
907060 SYRDDYRKMVVEPASPCLIRYRRRDAP 906980

>CYP51B1     Nocardia farcinica IFM 10152 (Actinobacteria) AP006618.1
MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFE
LAGKQVILLSGAEANEFFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHN
SALRAEQMRGHATTIAAEVDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNE
LDDRFARLYHELERGTDALAYVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPA
DKSDRDLLDVLVSVPNEDGGPRFSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHP
ELRDRVVAELDELFADGKDVSFHALRQIPLLEATLKETLRMHPPLIILMRVAQGDFEV
CGHHIAAGDHVAATPAISNRLPEDFPDPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRH
RCVGAAFALMQLKAIFSILLRDWEFEMAQPSESYRNDHSKMVVQLQQPCRVRYRRRVR
TS

>CYP101 M12546 Pseudomonas putida
MTTETIQSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWA
VLQESNVPDLVWTRCNGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPT
SMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPFP
IRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQKPGT
DAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLSFSMEFLAKSPEHRQELI
ERPERIPAACEELLRRFSLVADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENA
CPMHVDFSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQH
KSGIVSGVQALPLVWDPATTKAV

>CYP101B1    Novosphingobium aromaticivorans NZ_AAAV01000165.1 
MLPHDRGQNSTRRITAMEAPAHVPADRVVDIDIYMPPGLAEHGF
HKAWSDLSAGNPAVVWTPRNEGHWIALGGEALQEVQSDPERFSSRIIVLPKSVGEMHG
LIPTTIDPPEHRPYRQLLNAHLNPGAIRGLSESIRQTAVDLIEGFAAQGHCNFTAQYA
EQFPIRVFMALVGIEASEAPRIRHWAECMTRPGMDMTFDEAKAVFFDYVGPLVDARRE
TPGEDMISAMINADLGDGRRLTRDEALSVVTQVLIAGLDTVVNVLGFIMRELAGNPAL
RADLRQRGADILPVVHELFRRFGLVSIAREVRRDIEFHGVHLKAGDMIAIPTQVHGLD
PRVNPDPLAIDPSRKRARHSTFGSGPHMCPGQELARKEVAITLEEWLRRIPDFALGPN
SDLSPVPGIVGALRRVELVWNT

>CYP101C1   Novosphingobium aromaticivorans NZ_AAAV01000133.1 
MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTA
NGGHWIAARGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVM
KGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR
PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRP
WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLIPAAADELMR
RYPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIR
HTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPL
VWRA

>CYP101D1   Novosphingobium aromaticivorans NZ_AAAV01000085.1 
MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAW
KRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVP
TKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVF
PVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAA
RRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP
ETVAEMRREPLKLQRGVEELFRRFAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHG
LDDRHHDDPMTVDLSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLK
DRAVPIYHSGIVAAVENIPLEWEPQRVSA

>CYP101D2   Novosphingobium aromaticivorans NZ_AAAV01000042
MGTTRMDTFNPQESRLATNFDEAVRAKVERPANVPEDRVYEIDM
YALNGIEDGYHEAWKKVQHPGIPDLIWTPFTGGHWIATNGDTVKEVYSDPTRFSSEVI
FLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA
RGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAG
NNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVV
NFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFPVVSEARMVAKDQEYKGVFL
KRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGGPHRCAGMHLARMEVIVT
LEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR

>CYP102A1 J04832 Bacillus megaterium P450 half
MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFE
APGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHN
ILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFN
YRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVD
KIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSF
ALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL
YAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFK
PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAK
SKKIPLGGIP

>CYP102A2 P450 part (N-terminal half) Bacillus subtilis
MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI
HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH
NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF
NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV
DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL
SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF
SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA
YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS
VQSRHQEAIHADVQAAEKAAPDEQKEKTE

>CYP102A3 U93874 Bacillus subtilis P450 half
MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF
DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH
RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF
NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV
DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL
SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF
SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA
YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT
VKPRKTAAINV

>CYP102A4    Bacillus anthracis str. Ames P450 half
1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFRMQTLSD TIIVVSGHEL
  61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETQEPNWQ KAHNILMPTF SQRAMKDYHA
 121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
 181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
 241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
 301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
 361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
 421 MLLQHFEFID YEEYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKNHEIKQ

>CYP102A5    Bacillus cereus ATCC 14579 P450 half
1 MEKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKIAEEYG PIFQIQTLSD TIIVVSGHEL
  61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
 121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
 181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG DQEENDLLSR
 241 MLNVPDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
 301 VLTDPTPTYQ QVMKLKYMRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
 361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
 421 MLLQHFELID YQNYQLDVKQ TLTLKPGDFK IRILPRKQTI SHPTVLAPTE DKLKNDEIKQ

>CYP102A6    Bradyrhizobium japonicum USDA 110 P450 half
1 MSSKNRLDPI PQPPTKPVVG NMLSLDSAAP VQHLTRLAKE LGPIFWLDMM GSPIVVVSGH
  61 DLVDELSDEK RFDKTVRGAL RRVRAVGGDG LFTADTREPN WSKAHNILLQ PFGNRAMQSY
 121 HPSMVDIAEQ LVQKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
 181 SLVRSLETIM MTRGLPFEQI WMQKRRKTLA EDVAFMNKMV DEIIAERRKS AEGIDDKKDM
 241 LAAMMTGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYTLYALLKH PDILKKAYDE
 301 VDRVFGPDVN AKPTYQQVTQ LTYITQILKE ALRLWPPAPA YGISPLADET IGGGKYKLRK
 361 GTFITILVTA LHRDPSVWGP NPDAFDPENF SREAEAKRPI NAWKPFGNGQ RACIGRGFAM
 421 HEAALALGMI LQRFKLIDHQ RYQMHLKETL TMKPEGFKIK VRPRADRERG AYGGPVAAVS

>CYP102A7  Bacillus licheniformis ATCC 14580 AAU24352 P450 half
1 MNKLDGIPIP KTYGPLGNLP LLDKNRVSQS LWKIADEMGP IFQFKFADAI GVFVSSHELV
  61 KEVSEESRFD KNMGKGLLKV REFSGDGLFT SWTEEPNWRK AHNILLPSFS QKAMKGYHPM
 121 MQDIAVQLIQ KWSRLNQDES IDVPDDMTRL TLDTIGLCGF NYRFNSFYRE GQHPFIESMV
 181 RGLSEAMRQT KRFPLQDKLM IQTKRRFNSD VESMFSLVDR IIADRKQAES ESGNDLLSLM
 241 LHAKDPETGE KLDDENIRYQ IITFLIAGHE TTSGLLSFAI YLLLKHPDKL KKAYEEADRV
 301 LTDPVPSYKQ VQQLKYIRMI LNESIRLWPT APAFSLYAKE ETVIGGKYLI PKGQSVTVLI
 361 PKLHRDQSVW GEDAEAFRPE RFEQMDSIPA HAYKPFGNGQ RACIGMQFAL HEATLVLGMI
 421 LQYFDLEDHA NYQLKIKESL TLKPDGFTIR VRPRKKEAMT AMPGAQPEEN GRQEERPSAP

>CYP102B1 streptomyces coelicolor AL136502.2
MAQTAREPARDGLPKGFRSAELGWPELHRIPHPPYRLPLLGDVV
GASRRTPMQDSLRYARRLGPIFRRRAFGKEFVFVWGAALAADLADEARFAKHVGLGVA
NLRPVAGDGLFTAYNHEPNWQLAHDVLAPGFSREAMAGYHVMMLDVAARLTGHWDLAE
ASGRAVDVPGDMTKLTLETIARTGFGHDFGSFERSRLHPFVTAMVGTLGYAQRLNTVP
APLAPWLLRDASRRNAADIAHLNRTVDDLVRERRANGGTGGGTGSGSGSGDLLDRMLE
TAHPRTGERLSPQNVRRQVITFLVAGHETTSGALSFALHYLAQHPDVAARARAEVDRV
WGDTEAPGYEQVAKLRYVRRVLDESLRLWPTAPGFAREAREDTVLGGTHPMRRGAWAL
VLTGMLHRDPEVWGADAERFDPDRFDAKAVRSRAPHTFKPFGTGARACIGRQFALHEA
TLVLGLLLRRYELRPEPGYRLRVTERLTLMPEGLRLHLVRRTAAAPAPGRRTAAPGAA
DDAGDTVSAPGCPVHRAGD

>CYP102B2 SAV7426 AP005050 Streptomyces avermitilis
MAQSTRTVIPKGFRSAELGWPELHRIPHPPHRLPVVGDVLGVNV
RTPVQDSLRIGRRLGPVFRRKAFGKEIVFVGGADLAAELADESRFAKHVGLGVANLRP
VAGDGLFTAYNHEPNWQLGHDVLAPGFSREAMAGYHPMMLAVTERLIDHWDREQTAGR
AVDVPGDMTKLTLETIARTGFGHDFGSFERARPHPFVTAMVGTLTYAQRRNVVPEPLA
PLLLRTATRRNAADLAYLNRTVDALVRARRTTSGEGDLLDRMLDTARPGTGERLAPEN
IRRQVITFLVAGHETTSGALSFALHYLSRHPDVAARARAEVDRVWGGTARPGYDQVAK
LRYVRRVLDESLRLWPTAPAFAREARRDTVLGGVHPMREGAWALVLTAMLHRDPGVWG
ADAERFDPDRFDAQAVRSRAAHTFKPFGTGARACIGRQFALHEATLVLGLLLRRYELR
AEPGYRLRVAERLTLMPEGLRLRLDRRVPAVEDVPVANPEVSSGPRCPVTGAGE

>CYP102C1 partial AF059700 Rhodococcus sp.
AAAGGKIDATADANKLALDVIGLAGFGYDFASFDGDEHPFVGAM
SRVLEHVNRTSNDIPFLRKLRGNGADLQYEKDIAFVRTVVDDVITERQAKPGEHQDDL
LDLMLNNIDDETGEKLDPVNIRNQVLTFLVAGNETTAGAIAFALYFLSRHPEIADAAR
AEVADITGGETPAFEDVARMRYLRRVVDETLRLWPSAPGYFRKVRTDTTLGGRYAMPK
GSWVFVLLPQLHRDPVWGENPDSFDPDRFKPENVKKRPAHAYRPFGTGPRSCIGRQFA
LHEAVLSLATILQRYSFQSDPEYKLDVREALTLKPVGLELSLQRL

>CYP102D1 SAV575 AP005023 Streptomyces avermitilis
MTTQPETDLRPIRSPRGVPLFGHTPQIPSTNPVEYFGKLSKQFP
EGLYGMEIAGIEQVFVWDPDLVAEVCDETRFFKQIDKTPLAHVRDYAGAGLFTAHQHE
EEWGMAHRVLLPVFSQRAMKGYFGQMLEIAQNLVGKWERKEGQPVNITDDYTRLTLDT
IALSGFGYRFDSFAKEDLHPFLNALLQALVESLRRSQELPVMTKMRKADDKKYRENIR
LMRDLVENVIKERREGKGTGEDDLLGLMLEATDPETGKGLDDDNVRDQVVTFLIAGHE
TTSGLLSFATYSLMRNPHILAQAYAEVDRLLPGDTVPDYDTIMQMDVIPRILEETLRL
WAPIPMIGKSPLEDTVIGGCYGLKKGARVNILEGPLHTHPKAWERPEEFDINRWLPEN
RVNHHPHAYKPFGNGVRACIGRQFALTEARLALALVLQKFKFADTDDYKMDVKEALTR
KPGGFELNVRARQEHERTVFGAAD

>CYP102E1   Ralstonia metallidurans GenEMBL NZ_AAAI01000371 
MSTATPAAALEPIPRDPGWPIFGNLFQITPGEVGQHLLARSRHHDGIFELDFAGKRVPFVS
SVALASELCDATRFRKIIGPPLSYLRDMAGDGLFTAHSDEPNWGCAHRILMPAFSQRAM
KAYFDVMLRVANRLVDKWDRQGPDADIAVADDMTRLTLDTIALAGFGYDFASFASDELDP 
FVMAMVGALGEAMQKLTRLPIQDRFMGRAHRQAAEDIAYMRNLVDDVIRQRRVSPTSGMD 
LLNLMLEARDPETDRRLDDANIRNQVITFLIAGHETTSGLLTFALYELLRNPGVLAQAY 
AEVDTVLPGDALPVYADLARMPVLDRVLKETLRLWPTAPAFAVAPFDDVVLGGRYRLRKD 
RRISVVLTALHRDPKVWANPERFDIDRFLPENEAKLPAHAYMPFGQGERACIGRQFALTE 
AKLALALMLRNFAFQDPHDYQFRLKETLTIKPDQFVLRVRRRRPHERFV
TRQASQAVADAAQTDVRGHGQAMTVLCASSLGTARELAEQIHAGAIAAGFDAKLADLDDA
VGVLPTSGLVVVVAATYNGRAPDSARKFEAMLDADDASGYRANGMRLALLGCGNSQWATY
QAFPRRVFDFFITAGAVPLLPRGEADGNGDFDQAAERWLAQLWQALQADGAGTGGLGVDV
QVRSMAAIRAETLPAGTQAFTVLSNDELVGDPSGLWDFSIEAPRTSTRDIRLQLPPGITY
RTGDHIAVWPQNDAQLVSELCERLDLDPDAQATISAPHGMGRGLPIDQALPVRQLLTHFI
ELQDVVSRQTLRALAQATRCPFTKQSIEQLASDDAEHGYA

>CYP102F1   Actinosynnema pretiosum subsp. Auranticum AF453501 
MVATGTRIPGPKPLPLVGNLLDVLTSDLDTDVDFLDRCHREHGG
IVALTFAGQRQVFASSHELVARMCSDPSWGKAVHPALEQVRDFAGDGLFTARGDEPNW
GKAHRLLMPAFGPTAMRDHFPAMLDIAEQMLVRWRRFGPDHRIDVADDMTRLTLDTIA
LCAFGARFNSFYRDRAHPFVDAMVRSLVEAGERAERLPGVQPFLVGRNQRYRDDIATM
NRIADGIVAARAALPAGERPDDLLERMLTCADPVTGERLSARNVRYQLATFLIAGHET
TSGLLSFAVHRLLAHPEVLRKAKDAVDGVLGDRVPAFEDLARLDYLGQVLRETLRLHP
TAPAFALAPDEPAELGGHAIGAGEPVLVMLPTLHRDPAVWRDPDVFDPERFAPERMDE
IPACAWMPFGHGARACIGRPFALQEATLVLALVLQRFDLALADPDHRLTIKQTLTLKP
DSLVVRARPRADRPGATA

>CYP103A1 M19352, AF242881 Agrobacterium tumefaciens
MIANSSTDVSVADQKFLNVAKSNQIDPDAVPISRLDSEGHSIFA
EWRPKRPFLRREDGIFLVLRADHIFLLGTDPRTRQIETELMLNRGVKAGAVFDFIDHS
MLFSNGETHGKRRSGLSKAFSFRMVEALRPEIAKITECLWDDLQKVDDFNFTEMYASQ
LPALTIASVLGLPSEDTPFFTRLVYKVSRCLSPSWRDEEFEEIEASAIELQDYVRSVI
ADSGRRMRDDFLSRYLKAVREAGTLSPIEEIMQLMLIILAGSDTTRTAMVMVTALALQ
NPALWSSLRGNQSYVAAAVEEGLRFEPPVGSFPRLALKDIDLDGYVLPKGSLLALSVM
SGLRDEKHYEHPQLFDVGRQQMRWHLGFGAGVHRCLGETLARIELQEGLRTLLRRAPN
LAVVGDWPRMMGHGGIRRATDMMVKLSFDL

>CYP103A2 AF034769 Agrobacterium tumefaciens 
MITSSISGTDQQFQNATQPKELDPDAVPVSRLDSEGHEIFAEWR
PKRPFLRREDGVFLVLRADDIFLLGTDPRTRQIETELMLNRGVTRGAVFDLIRYSMLF
SNGEVHVKRRSAFAKTFAFRMIDALRPEITKLTEHLWDDVPRVDDFDFAEMYASKLPA
LTIASVLGLPFGDAPFFTRLVYNVSRCLSPSWGEDDFPEIEASAVELQDYVRAVVADR
SRRISDDFLSCYLKAVREEGTLSPIEEIMQLVFLILAGSDATRNAMVMLPTLLLQNPV
VWSSLCHDQSGVAAAVEEGLRFEPSVGSFPRLALEDIDLDGYVLPKGSFLALSIMSGL
RDERHYEHPQLFDIKRKQMRRHLGFGAGVHRCLGEALARIELQEGLRTLLRRAPSLRV
TGDWPRMIGHGGARRATGMTVNLGVDR"

>CYP103A3   Agrobacterium tumefaciens vir region GenEMBL AF329849 892..2148
MNARGPEKVSQTSGPIISASLDPDNVSVSDLDRSGHAIFAEWRP
KRPFLRRQDGVYVLLRADDVLGLSSDPRTRQIETELMLNRGINEGAVFDFVRYSMLFS
NNEVHSRRRSPFTRTFAFRMIENLRPQVSQLTETLFQDLKELDSFNFVEEFASKLPAV
AIAGLLGLPPSDIPYFTQLVYRVARCLSPSWRDADLPDIEASAAEFKNYVQAVIDDRR
SNPRDDFLSSFIRATREAEDLSPDEGLAQLMLIVLAGTDTTKTGLTALTGQLLRHRHV
WEALLKDESLVPAAVEEGLRFEPPVGSYPRLALADIDLEGFILPKGSLLALCTMSALR
DEKHFAHPELFDIHRKQMHWHMVFGAGAHRCLGEALARLELQEGLATVLRYAPTLSIE
GEWPTVQGHGGVRRIAEMRVGFRRQI

>CYP104A1 M19352, AF242881 Agrobacterium tumefaciens MEERRVSISSITWRFPMLFAPVDDVTTIDDLTLDPYPIYRRMRV
QNPVVHVASVRRTFLTKAFDTKMVKDDPSRFSSDDPSTPMKPAFQAHTLMRKDGTEHA
RERMAMARAFAPKAIADHWAPIYRDIVNEYLDRLPRGDTVDLFAEICGPVAARILAHI
LGICEASDVEIIRWSQRLIDGAGNFGWRSELFERSDEANAEMNCLFNDLVKKHRSAPN
PSAFATMLNAPDPIPLSQIYANIKIAIGGGVNEPRDALGTILYGLLTNPEQLEEVKRQ
QCWGQAFEEGLRWVAPIQASSRLVREDTEIRGFIVPKGDIVMTIQASANRDEDVFEDG
ESFNVFRPKSAHQSFGSGPHHCPGAQISRQTVGAIMLPILFDRFPDMILPHPELVQWR
GFGFRGPINLPVTLR

>CYP104A2 AB016260 Agrobacterium tumefaciens 
MQLAPVDRVTTIDDLTLDPYPIYRRMRAQTPVVRVASVMRTFLT
KASDTKMVKDQPRRFSSDDPNTPMKPAFQAHTLMRKDGAEHARERMAMAKAFAPKTTA
EHWAAIYRDIVNEYLDRLSRGSTVDLFAEICGPVAARILAHVLGISEASDAEMIRWSQ
RLIEGAGNFGWRPEPFERANEANAEMNRLFDNLVEKHRAEPNPSAFAIMVTASDPIPM
SQIYANIKIAVGGGINEPRDALGTIIYGLLTNPEQFEEVKRQQCWGQVFEEGVRWVAP
IQASSRLVLEDTEIRGFLVPKGDTVMTIQASANRDEDVFDDGERFNVFRQNNAHQSFG
SGPHHCAGAQISRQTVGAIMLPTLFERFPNMTLTNPDAVQWRGFGFRGPISLPVTLI

>CYP105A1 suaC Y18556.1 Streptomyces griseolus
MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVT
LYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPE
HGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVIC
RLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGA
LVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSL
VPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPD
ALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRP
GTTIQGVNELPVTW

>CYP105A2 D26543 Amycolata autotrophica
MTTDATDPRTTDAAPFPSNRSAPYRFSDGYAQLRDPPGPLRLGT
RYDGRQAWVVVIHEAARKLLASRFESADAHRTGFPFLTAGGRDMIGTNPTLFRMDDPE
HARLRRMTISHYTVKRIKTISEFVEEVVLVFLRRMTISGPTADLVSQFLIGAGHMVIC
RLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLQYLARLARTKRERPDDAIIS
RLVARGEILREEDISDAMLLLIAGHATDANLTSMSLYALADRSEQYAALRADRSLVPG
AVEDPLRYVAIADIATEDVPIRGRTIAAGNTQIAMGSSANLDHEYYEDPDALTARVED
LVHLAFGFGRHQCLGQNLARADQLREDLMTARNDPTLRLAVPVQSSARLEGTTIQGVN
ELPVTW

>CYP105A3 D30815 sca-2 Streptomyces carbophilus
MTEMTEKATTFLTSQEAPAFPADRTCPYQLPTAYSRLRDEPDAL
RPVTLYDGRRAWVVTKHEAARRLLADPRLSSDRLHADFPATSPRFKAFRQGSPAFIGM
DPPEHGTRRRMTISEFTVKRIKGMRPDVERIVHGFIDDMLAAGPTADLVSQFALPVPS
MVICHMLGVPYADHEFFQDASKRLVQAVDADSAVAARDDFERYLDGLITKLESEPGTG
LLGKLVTHQLADGEIDRAELISTALLLLVAGHETTASMTSLSVITLLEHPDQHAALRA
DPSLVPGAVEELLRVLAIADIAGGRIATADIEIDGQLIRAGEGVIVTNSIANRDSSVF
ENPDRLDVHRSARHHLSFGYGVHQCLGQNLARLELEVILTVLFDRIPTLRLAVPVEQL
TLRPGTTIQGVNELPVTW

>CYP105B1 subC SU-2 M32239 Streptomyces griseolus
MTTAERTAPPDALTVPASRAPGCPFDPAPDVTEAARTEPVTRAT
LWDGSSCWLVTRHQDVRAVLGDPRFSADAHRTGFPFLTAGGREIIGTNPTFLRMDDPE
HARLRRMLTADFIVKKVEAMRPEVQRLADDLVDRMTTGRTSADLVTEFALPLPSLVIC
LLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLEYLARLARTKRERPDDAIIS
RLVARGELDDTQIATMGRLLLVAGHETTANMTALSTLVLLRNPDQLARLRAEPALVKG
AVEELLRYLTIVHNGVPRIATEDVLIGGRTIAAGEGVLCMISSANRDAEVFPGGDDLD
VARDARRHVAFGFGVHQCLGQPLARVELQIAIETLLRRLPDLRLAVPHEEIPFRGDMA
IYGVHSLPIAW

>CYP105C1 choP M31939 Streptomyces sp.
MTQAAPVTFSTVRENYFGPPAEMQALRHKAPVTRTAFADGRPGW
LVTGYSAARAVLSDSRFTARGEREHPAVPRAATLEDERCRRLIAGQFTARRMRQLTGR
TERIVREHLDAMEHMGSPADLVEHFALPVPSLVIAELLGVPPPDREHFQHDTLRWGGF
GRSTEEVTEAFVSLGGQLQRLVRLKRTEPGDDLLSGLIAADPALTDEELASIAFLLLV
AGHGTTAHQIALGAFLLLEHPDQLAALRADPALTESAVEELLRHLSVVHHGPTRAALQ
DADIEGTPVKAGEVVVVSLGAANRDPARFERPDAVDVTREDTGHLAFGHGMHQCLGRQ
LARIELRVALTALLERFPHLRLACPAAEIPLRHDMQVYGADRLPVAW

>CYP105D1 P450soy X63601 Streptomyces griseus
MTESTTDPARQNLDPTSPAPATSFPQDRGCPYHPPAGYAPLREG
RPLSRVTLFDGRPVWAVTGHALARRLLADPRLSTDRSHPDFPVPAERFAGAQRRRVAL
LGVDDPEHNTQRRMLIPTFSVKRIGALRPRIQETVDRLLDAMERQGPPAELVSAFALP
VPSMVICALLGVPYADHAFFEERSQRLLRGPGADDVNRARDELEEYLGALIDRKRAEP
GDGLLDELIHRDHPDGPVDREQLVAFAVILLIAGHETTANMISLGTFTLLSHPEQLAA
LRAGGTSTAVVVEELLRFLSIAEGLQRLATEDMEVDGATIRKGEGVVFSTSLINRDAD
VFPRAETLDWDRPARHHLAFGFGVHQCLGQNLARAELDIAMRTLFERLPGLRLAVPAH
EIRHKPGDTIQGLLDLPVAW

>CYP105D2 AF071145 Streptomyces griseus
LLIAGHETTANMISLGTFTLLNHPEQLEALRSGRTTTAAVVEEL
LRFLSIAEGLQRLATEDIEVAGTTIREGEGVFFSTSLINRDTEVYENPETLDWDRPSR
HHLAFGFGVHQCLGQNL

>CYP105D3 AF071149 Streptomyces sclerotialus
LLIAGHETTANMISLGTYTLLRHPDRLAELRADPGLAPAAVEEL
LRMLSIADGMLRVATEDIEAGGTVIRAGDGVIFGTSVINRDETVYTDPDALDWHRPAR
HHVAFGFGIHQCLGQNL

>CYP105D4 AF072709  Streptomyces lividans 69% to 105D1 67% to 105D2 82% to 105D3 
MTDTDTTTNTHPAAPVAFPQDRTCPYHPPAAYDPLRTARPLARI
TLFDGRPAWLVTGHAAARRLLADQRLSTDRTRDGFPATSARLAAVRERRTALLGVDDP
EHRAQRRMVLPEFTLKRAGALRPSIRRIVGERLDAMIAQGPPADLVTAFALPVPSMVI
CALLGVPYADHEFFEEQSRRLLRGPLPADTRDARDRLEAYLGELIDRKRRAPGEGLLD
DLVRRQASEGATDREQLIAFAVILLVAGHETTANMISLGTYTLLTNPGRLAELRADPA
LLPGAVEELMRVLSIADGLLRMATEDIDVDGQTIRAGDGVVFSTSVINRDESVYPEPD
ALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALESLFDRLPTLRLAAPADEIPFKP
GDTIQGMLELPVAW

>CYP105D5 AL445945.2 SC3F60 Streptomyces coelicolor cosmid 3F60
3343 MTDTDTTTNTDTTTNT
3295 HPAAPVAFPQDRTCPYHPPAAYDPLRAARPLARITLFDGRPAWLVTGHAAARRLLADQRL 3116
3115 STDRTRDGFPATSARLAAVRERRTALLGVDDPEHRAQRRMVLPEFTLKRAGALRPSIRRI 2936
2935 VGERLDAMIAQGPPADLVTAFALPVPSMVICALLGVPYADHEFFEEQSRRLLRGPLPADT 2756
2755 RDARDRLEAYLGELIDRKRRAPGEGLLDDLVRRQASEGATDREQLIAFAVILLVAGHETT 2576
2575 ANMISLGTYTLLTNPGRLAELRADPALLPGAVEELMRVLSIADGLLRMATEDIDVDGQTI 2396
2395 RAGDGVVFSTSVINRDESVYPEPDALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALE 2216
2215 SLFDRLPTLRLAAPADEIPFKPGDTIQGMLELPVAW* 2105

>CYP105D6 SAV412_pteD AP005022 Streptomyces avermitilis
MNAALPMFERHDMTETEIRLTGSPAPSFPQDRTCPYQPPKAYEE
RRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGL
AFPLIGVDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADLVSA
FALPVPSVAICELLGVPYGDHDFFEECSRNFVGAATSAEADAAFGELYTYLHGLVGRK
QAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE
QIDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMN
RDAKAYENPDIFDARRNARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA
VPLDEVPIKAGHDAQGPIELPVVW

>CYP105D7 SAV7469 AP005050 Streptomyces avermitilis
MEIGKSKSSPARSFMTEPGTSVSAPVAFPQDRTCPYDPPTAYDP
LREGRPLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTR
RVALLGVDDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSA
FALPLPSMVICALLGVPYADHDFFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDRK
RKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPE
QLAELRAEPGLMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVIN
RDAAGFAEPDALDWHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLA
APADEIPFKPGDTIQGMLELPVTW

>CYP105D9   Streptomyces sp. JP95 GenEMBL AF509565 11774..13024
MTDTLDEPQTLADGAEDAPAYPVKRTCPYRMPPGYEELREKGPI
SRVTLWNGRTAWLVTGNDLGRRLFPDARLSSDVLDPRFPLLAPRIEAQRQQAAAPPLV
GVDDPVHARQRRMVLPSFGIRQINALRPEIQKYADDLLDTMLAKGPGVTVDLLTEYAL
PMPSAVICMLLGVPYEDHHYFDERSRHVLSSSGEEQAAQAQQAFTEILAYLDDLIVRK
QAEPGDTLLDELIARQLEEGKVDRQELAMIATVLLVSGHETTSNMIALSTMALLADPD
QLAALRADESLMPRAVDELMRFSSIGDMLMRVAKEDIEIEGHLIRAGDGVILSTMLMN
RDPGAFERPDELDIRRPAGRHVAFGYGIHQCIGQNLARAEMEIALATLFRRVPTLKLA
VPAEQVPVNAPFVLQGVSELPVTW

>CYP105E1 Z29635 Rhodococcus fascians
MAGTADLPLEMRRNGLNPTEELAQVRDRDGVIPVGELYGAPAFL
VCRYEDVRRIFADSNRFSNAHTPMFAIPSGGDVIEDELAAMRAGNLIGLDPPDHTRLR
HILAAEFSVHRLSRLQPRIAEIVDSALDGLEQAGQPADLMDRYALPVSLLVLCELLGV
PYADRDELRDRTARLLDLSASAEQRAVAQREDRRYMATLVTRAQEQPGDDLLGILARK
IGDNLSTDELISIISLIMLGGHETTASMIGLSVLALLHHPEQAAMMIEDPNCVNSGIE
ELLRWLSVAHSQPPRMAVTEVQIAGVTIPAGSFVIPSLLAANRDSNLTDRPDDLDITR
GVAGHLAFGHGVHFCLGHSLARMTLRTAVPAVLRRFPDLALSPSHDVRLRSASIVLGL
EELQLTW

>CYP105F1 AF127374  Streptomyces lavendulae LinA homolog. 
MSDTEQHAPTLPRQRTCPFSPPPELEELRRTDPISRMRFADDSP
GWLLTRHADVRAALADPGVSSHPGKAPQPWRNLAPEMRAEHYLPGFLIFMDPPDHTRY
RRLLTKWFTMRAIRKLEPRIEQIVTETLDAMEAQGGTVDLVQSFALPIPLLVICELMG
IRYEEREEFMDMVLRLQALDATPEELGALGARMNEFMMKLAAAKRANPGDDLLSHLAH
DPDADPALTDLEIAGIGVLMLIAGHETSANMLGVGTYTLLENADQWALLRDDISLIDR
AVEELLRHQTIVQQGLPRGVTRDMEIAGHQVKTGESLLASLPAANRDPAVFPDPDRLD
ITREHNPHLAFGHGIHLCLGMELARVEMRQAWRGLVTRFPGLRMAAAPEDIRWRDDQI
VYGVYNLPVTWDEAK

>CYP105G1 AF040571  Amycolatopsis mediterranei thioester CDS 
MTTKVTENAPSTESLRSPLPPEFVRREDPFHVPPALVAVSERGP
VARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPRFKELSPEFAFPAPSLMIC
ELLGVRYEDRAEFQQRASALLQMNAPVAEAVKNADALRAFMQALVTDKRANPAGDIIS
GLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPS
RIADAVEGLLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP
DLDLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVPLRN
DMLTYGVHSLPIAWDAP

>CYP105H1 AF263912  Streptomyces noursei ATCC 11455 nyst gene="nysN" 
MSTEADARTAAPQCPVAFPLRRPGRPFPPPEYATYRGGAGLVRS
ELPSGPVWLVTRHEDVRAVLTDPRISADPSKPGFPKAGRTGGAPSQYEVPGWFVAMDP
PEHGRFRKTLIPEFTVRKVRELRPVIQQIVDERIDAMLAAGTSADLVESFALPVPSLV
ISSLLGVPKVDRDFFEDRTRVLVRLSSTDEERDKATQALLRYLGRLIQIKQRRPGDDL
ISRLIAAGTLSRQELSGVAMLLLIAGHETTANNIGLGVVQLLTNPRWIGDDRIVEELL
RYYSVADLVAFRVAVEDVEIGGQLIRAGEGIVPLIAAANHDATAFAAPSEFDPERSAR
SHVAFGYGVHQCLGQNLVREEMDIAYRTLFARIPSLTLAVPVEELPLKYDGVLFGLHE
LPVTWK

>CYP105H2    Streptomyces albus GenEMBL AF071143 77% to 105H1
LLIAGHETTANNIGLGVVTLLSHPQWAGDERAVEELLRLHSVAD
MVALRVAVDDVEIAGQVIRKGEGIVPLLAAANHDTEVFGCPHAFDPERSERRHVAFGY
GVHQCLGQNL

>CYP105H3   Streptomyces natalensis GenEMBL AJ278573 52789..53985
MTYTDPAAPETDPPAVDFPQRKPGVPFPPPDYADYRDRKGLVLS
QLSDGKRVWLVTRHEDVRAVLTSPSISSNPEHKGFPNVGNLGVPKQDQIPGWFVGMDS
PEHDRFRKALIPEFTVRRVRAMKPAIERTVDAQLDAMLAAGNTADLVADFALPIPSLV
ISALLGVPPADREFFESRTRVLVSLRSSTDDDRMAAAKDLLRYINRLVEIKQKWGGDD
LITRLLATGAIAPHEMSGVLMLLLIAGHETTANNIALGVVTLLANPQWIGDDRAVEET
LRFHSVADLVSLRVAVQDVEIAGQLIKAGEGIVPLVAAANHDENAFECPHAFDPSRSA
RHHVAFGYGVHQCLGQNLVRIEMEVAYRKLFERIPNLELAVPTDGLDIKYDGVLYGLN
ELPVRW

>CYP105H4   Streptomyces nodosus GenEMBL AF357202 complement(62051..63250)
MTAETEMTTFAPGCPVAFPLRRPGRPFPPPEYADYRAGEGLVRS
ELPASGPVWLVTRHEDVRTVLTDPRISADPSRPGFPRARRTGGAPSQSEIPGWFVALD
PPEHDRFRKTLIPEFTVRKVRELRPAIQQIVDERIDALLAAGNSADLIADFALSVPSL
VISDLLGVPKADRDFFEAKTKVLVTLSSTDEQRDEASKALLRYLNRLIQIKGRRPGED
LISRLLQAGTMNRQELSGVSMLLLIAGHETTANNIGLGVVQLLTNPQWIGDDRIVEEM
LRYYSVADLVSFRVAVEDVEIGGQLIKAGEGIVPLIAAANHDGSVFDKPEEFNPERSA
RSHVAFGYGVHQCLGQNLVRVEMEIAYRTLFERIPTLELAVPVEELPLKYDGVLFGLH
ELPVTWS

>CYP105H5   Streptomyces griseus GenEMBL AJ300302 10678..11859
MTTSPGPTVVDFPRRTPREPLPLSQYAEHRKQNGLVQTHLPNGR
PIWLVTRHEDVRAVLTHPRISANPDNEGFPNVGETMGVPKQEQIPGWFVGLDSPEHDR
FRKVLIPEFTVRRVRELRPAIERTVDERIDAMLAGGNTADLVNDFALPVPSLVISALL
GVPSADRDFFESRTRTLVAIRTSTDEERAEATRQLLRYINRLIVIKKKWRGEDLISRL
LSTGKLSDEELSGVLLLLLIAGHETTANNIGLGVVTLLSHREWIGDDRLVEELLRLHS
VADMVALRVAVDDVEIAGQTIRKGEGIVPLLASANHDTEAFGCPHAFNPERTERRHVA
FGYGVHQCLGQNLVRVEMEIAYRKLFERIPELRLAVPEDQLAYKYDGILFGLHELPVRW

>CYP105J1 AF040570  Amycolatopsis mediterranei rifamycin 
MTETVAFPQDRTCPYQPAPGYEPLADRRPIAEVTLYDGRKAWAV
TGHELARKLLCDPRISSDRTNPAWPMVSAAAAVEFTDVQQKVIKLLTALVGVDGPAHR
ARRKLVQAGFTVKRIDSLRPKIQALVDRQIDEMIAEGAPVDLLKKFASPVPLIALCDL
LGIPHEDQDYFEKKAHQILFGPDAGGAYDELMAYLTKLIDKAEQNPGEEGFLQALLAE
RDPSSDVDHEEILQMFLIVLVTGHDTTSSSIGLGAFTLLQHPERLAELRADPSLMPAA
VDELTRFVVVPDGLQRVAADDIEVDADTTIRKGDGVFFLFSLINRDEEAYEDGDRLDW
HRPTFRDHLTYGFGTHQCAGMNHARAIMEIAFRRLIDRLPGLRLAVPADEVRVKPGDA
FQGLAELPVTW

>CYP105K1 Y18574.1 Streptomyces tendae strain Tue901 gene="nikF"
MTETFGHDIPSFPMARECPMHPPAEYRKLRVQEPVSRVRMPDGQ
VAWLVLKHDLARKLLADPRVSADRLHPAFPGRLTAEQRTATERVRRLSTRRSMIHLDG
DEHGAHRKILTGEFSLRRIAALRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIRERAAASDALNDFLEDLVTEKERGEPTDD
LIGRLIARNRRTPVMTHDEIVGTAVMLLIAGHQTTANMISLGVVALLENPEHKARIAA
DPSLLPPAIEEMLRYFSVVENAPARVATEDIEIGGVTIRKDEGIVVSGLAADWDDEVF
EHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC

>CYP105K2   Streptomyces ansochromogenes GenEMBL AF469953  14..1246
MTEAFDHDIPSFPMARECPMHPPAEYRELRGQEPVSRVRMPDGQ
VAWLVLKHALARKLLADPRVSADRLHPAFPGRLTAEQRAATERVRRLTTRRSMIHLDG
DEHGAHRRILTGEFSLRRIAAQRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIQERAAASDALNDFLEALVTEKERGEPADD
LIGRLIARNRQTPVMTHDEIVGTAVMLLVAGHQTTANMISLGVVALLENPEHKARIAA
DSSLLPPAIEEMLRYFSVVENAPARVATEDIAIGGVTIRKNEGIVVSGLAADWDDEVF
GHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC

>CYP105L1 AF147703  Streptomyces fradiae demethylmacroci gene=tylHI 
MAWAPDTVFSLRPQRVVSSSGDARPSQKGILLPAARANDTDEAA
GRRSIAWPVARTCPFSPPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPR
VSIHPAKLPRLSPSDGEAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRELRPSVEQI
VTGLLDDLTARGDEADLLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGE
EALEALLELRDYLDRLISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAG
HETTASMVTMSVLVLLQHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIE
IDGHTIRAGDGLVFLLAAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLAR
MELEVALGAVLERLPALRPTTDVAGLRLKSDSAVFGVYELPVAW

>CYP105L1 AF055922  Streptomyces fradiae tylH1 same as AF147703 shorter N-term
MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFS
PPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDG
EAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRDVRPSVEQIVTGLLDDLTARGDEAD
LLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRL
ISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL
QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLL
AAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA
LRPTTDVAGLRLKSDSAVFGVYELPVAW

>CYP105L2   Micromonospora griseorubida GenEMBL AB089954 1490..2641
MDRTCAWALPEQYAEFRQRATGWPAKVWDGSPTWLVSRYEHVRA
LLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMR
PEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELAS
RPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVL
LLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA
TADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLG
QNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW

>CYP105M1 AF200819  Streptomyces clavuligerus clavulanic 
MNEAAPQSDQVAPAYPMHRVCPVDPPPQLAGLRSQKAASRVTLW
DGSQVWLVTSHAGARAVLGDRRFTAVTSAPGFPMLTRTSQLVRANPESASFIRMDDPQ
HSRLRSMLTRDFLARRAEALRPAVRELLDEILGGLVKGERPVDLVAGLTIPVPSRVIT
LLFGAGDDRREFIEDRSAVLIDRGYTPEQVAKARDELDGYLRELVEERIENPGTDLIS
RLVIDQVRPGHLRVEEMVPMCRLLLVAGHGTTTSQASLSLLSLLTDPELAGRLTEDPA
LLPKAVEELLRFHSIVQNGLARAAVEDVQLDDVLIRAGEGVVLSLSAGNRDETVFPDP
DRVDVDRDARRHLAFGHGMHQCLGQWLARVELEEILAAVLRWMPGARLAVPFEELDFR
HEVSSYGLGALPVTW

>CYP105N1 AL450432.2 Streptomyces coelicolor
MTPPESPTASHTPGATPPRDFPIQRGCPFAAPAEYAALRTDDPV
ARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT
DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVST
SVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRD
DLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELR
KDPDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQ
FDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQ
VVVKHDSATFGLEELMVTW

>CYP105N2    Streptomyces glaucescens cytochrome P450 GenEMBL AF071144
LLIAGHETTTSMIALSTLLLLDRPELPAELRNDPDLMPAAVDEL
LRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD
NHHVAFGYGMHQCLGQNL

>CYP105P1 SAV413_pteC AP005022 Streptomyces avermitilis
MPEPTADAPTVPKARSCPFLPPDGIADIRAAAPVTRATFTSGHE
AWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLL
AKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTFANAVPSMVISDLFGVPVE
RRAEFQDIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDP
DGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDPSLVGNAVEE
LLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRR
PAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGV
HELPVTW

>CYP105Q1 SAV1611 AP005027 Streptomyces avermitilis
MADALAGRAPDATPPVAAYPMPRAVSCPLAPPPALQPLRDEQPI
TKVRIWNGSTPWLITRHADQRALLTDPRVSNDDRDPGFPYVNAHRAEIAHATPRLITN
TDAPEHTRLRRTVNAPFLIKRIEAMRPAVQRIVDGLIDDMLDGPNPADLLTALALPVP
SLVIAQLLGVPYADHEFFQRNSNLVLDNSVPAEEARAASGALAAYLDTLLAEKTAAPD
ADVLSEMGGRIKAGEMTHREAVHMGVAMLIAGHETTATMISLGTLALLEHPEQLAVLR
DAEDPKVIAAAVEELLRYLTIVHSGIRRVAKEDIEIGDRVIGAGDGLLFDLHAANWDS
EAFPEADRLDLSRPARHHQAFGYGPHQCLGQSLARLELQVVYGTLYRRFPTLRLAAPI
DRLAFHHTGTTYGVRCLPVTW

>CYP105Q2   Streptomyces sp. GenEMBL BD133549 78% to CYP105Q1 
  3 LIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHSGLRRVA 182
183 KGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGFGTHQC 350

>CYP105Q3   Streptomyces sp. GenEMBL BD133546 77% to 105Q1
 139 MADTLTDAAPDTDGRVPEYPMPRATGCPLAPSPAAAELRGDRPITRVRIWNGSTPWLITR 318
 319 HADQRTLLTDPRVSNDDHEPDFPHVNAHRAAIAPHTPKLITNTDAPEHTRLRRSVNAPFL 498
 499 VKRIEAMRPAVQKIVDDLIDDMLAGPSPADLLTALALPVPSLVIAELLGVPYEDHHFFQE 678
 679 NSNRVLDNSLTAEEAQESSRALGGYLDTLFRTKLEQPGEDVLSEMGSKVKAGEMTHQEAV 858
 859 SMGVAMLIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHS 1038
1039 GLRRVAKGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGYGPH 1218
1219 QCLGQNLARLELQVVYGTLYRRVLTLRPAVPVDQLAFNHTGTTYGVKCLPVTW 1377

>CYP105Q6   Mycobacterium vanbaalenii PYR-1  ZP_01205830.1, EAS26822.1 
MTETLAQEAVSVPEYPMERTAGCPFAPPQQMLEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVS VDDRREGFPHWNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVIQQVTDECIDEILA GPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLHQYLINLVEEKQ AHPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLENPEQAALLRDSDDPKFI ANAVEELMRYLSIIQNGQRRVATEDIEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRDATQQLG FGYGRHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYGVYELPVTW

>CYP105Q7   Mycobacterium smegmatis MSMEG4843 TIGR 
MSETLTQPSATDIPGYPMERAAACPFAPPPQMLDMNKAKGLSRVRIWDGS 
TPWLITGHEEARALFADSRVSVDDRRPGFPHWNEHMLATVHKRPRSVFTS 
DAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDECIDAILAGPQPADIVD 
KLALPVPTVVISEMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLH 
QYLIDLIEKKQAEPAEDAVSDLAERVTAGELSVKEAAQLGTGLLIAGHET 
TANMIGIGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQR 
RVAVEDIEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRDAGQQL 
GFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLA
YGVYELPVAW

>CYP105R1 SAV7186 AP005049 Streptomyces avermitilis
MTQTAAVTTAWPLHRTCPMSQPPALAAFRDGPPRQVLLRGDQPA
WLITRYADVRQALADPRLSVNDQHPNWPNRLLFPVPPRAVSFWRMDPPEHGAYRKMVA
AEFIAHRTQALRPLLQSITDELLDEMAAMPKPVDFHSVFALPLPCIAIARIFGVPDED
MSEFKENTSALLNQKEPEKAVQAFLATTAYLDGLARAKEREPKDDLLSRLVVNFVRPG
QLSHDDLVAMVRLMLVAGHETTANQIALSIFTLLDRPGVLAELRADPRLLTPVVDELL
RYWSIAQDNVVRTATEDLSVGDARIAAGDAVVISVPGANHDEAVFPDAADFDIHRDNS
RHLAFGHGPHFCPGGPLARTELEIAITSVFRRFPDLRLAIGRDQVPVHTDTLVYGLEC
LPVTW

>CYP105S1   Mycobacterium smegmatis MSMEG0758 TIGR 
MTQAQALPPLHIRRDAFDPTPELGEIRAGEGVHVTVNPFGMQVYLVTRHE
DVKTVLSDHERFSNSRPPGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQ
RLRRMLTPEFTIRRIKRLEPRIVEIVDAHLDAMESAGPPADIVADFALPI
PSLVICELLGVPYEDRTDFQQRSARQLDLSAPMPERLELQRQGRAYMRGL
VERSRTRPGDDILGMLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGL
GVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTTDVEL
AGVTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRRGAPGHLAFGHGVHHC
LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQSLAVAW

>CYP105S2   Mycobacterium vanbaalenii PYR-1 ZP_01208508.1, EAS22074.1 
MSQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPP GFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARD GEASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGAR TNPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPA VEELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGH GVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW

>CYP105T1   Burkholderia fungorum GenEMBL NZ_AAAJ02000095 
MRKTMTSAINDVRPQTTSTFPFARTGSPLHPPAEYARYRDGQPV
TRVQMWDGRYAWIFTRMEDVKAVLSSPHFSVVPSKPGYPFLTPARAATVKSYQTFITM
DPPDHTRFRRMLTRDFTQKRMEELRPQIAAYVNRLIDEMLARGSPGDLVSALALKLPV
TVVSMLVGVPYEDHEDLVKWSGQRLDLEQNPTVSESAADNMLAYFDGLLQRKERDPGD
GADMLSRLVIEQIKPGHLSRLEAIHMVNLLYFAGHETTANQIALGTLSFLLDPRQRAL
LENNPGLLKNAIEEMLRFHTISHYNSCRVATADVEVGGTLIREGEGAYALIMAANRDP
AAFPAPDRFDIERPNSQEHVAFSYGLHMCLGQPLARLELQVCFEALFRRLPRLRLAVP
LEELPFKREMYVYGLHALPVTW

>CYP105U1   Streptomyces hygroscopicus strain NRRL 3602 AY179507 
MDEIRDYPESRAAACPFSPPLGYEELRERSAVTRVRMWDGSTPF
LVTGYHEARAALGDSRFSADGTHKAMPRFVKFEVPAEVFNLGRMDDPEHARIRRMLTA
NFTIRRTEAMRPMIQGIVDGLLDRLIAQGPPADLVADFAFPLPSQVIGVMLGVSDADF
AEFQQASQGVMDFTASAEEMGAALGVMVDYVARMCAAKRADPGDDLLSRLIVDQELTG
GLTQQQVVATALVLLLAGHETTANMIALSTVLLLSHPEQLARLRADAGLMGNAVDELL
RYITIVQEGTGRVATEDVEVGGVLIPGGEGVIINLPSANRDPHFADAHELDLSRPNAR
EHVAFGFGVHQCLGQTLARVELQIALETLLRRLPTLRLEVPFDDLAFLYESMNFGVAR
VPVAW

>CYP105V1   Streptomyces sp. HK803 GenEMBL AY354515 36297..37508
MSQLSSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDG
KEVWLITGYDEIRSIFTDPRISVDNTQPGYPWLSEQARTVVLTGGVKPVGRMDPPEHT
AMRRMLGQGFLVKKIQNMRGDVEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWV
LGVPPADKRLISLVPRLFDEDSGLEGAMEARAELFAYIDELITHRENQPGDDIISHLV
GYYQKGELSRVSVLTQSVTLIAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPA
AVEELLRYTVVTEFSSKRVAAADIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLD
VRRDAKQHLGFGAGIHTCIGKQLARMELEVVYGTLFRRIPELRLAVPFDQLVFRNTFD
VQGVRALPVTW

>CYP105W1   Micromonospora echinospora GenEMBL AF497482 84045..85229
MPRRCPFGPPAEYARLRTERPVARLPMLGGNTAWVVSRYADVKR
VLSDPRMSADRRRAGFPRFAPTTESQRQASFANFRPPLNWMDPPEHTAARRQIVDEFA
ARRVRQLRPLVERVVDEHLDAMTAGRSSADLVPSFSYPVPSRVICEMLGVPYGEHAFF
ERRSTRMLSRGVPADERARCAREIREFLDGVVTDKERHPGDDVLSRLLAAQRAAGEPD
HEAVVSMAFVLLVAGHVTTSNMISLSVLALLTHPERLARLRAEPDRFPAAVEELLRYF
TIVEAATARTATADVTVGGVTIRAGEGVVALGQAANRDPAAFDRPDEFDPDRDARHHL
AFGYGRHICPGQHLARLELDVALSRLVRRLPGLRLTVDVDDLPLKEDGNIFGLHALPVAW

>CYP105X1   Pseudonocardia autotrophica GenEMBL AF525299 2766..3974
MAEDTLGQDFPMQRQCPFEPPKEYERLRAEQPISRVRMPDGTPA
WLVTLHEDVRTVLASPAFSSDLAHPGMPAVNPEIRTIARQQRPPFSRMDPPEHSFFRR
MLIPEFTVKRTKTLRAGIQSVVDGLIDDLLRKSPPVDLVDEFALPVPSLVICQLLGVP
YSRHEFFQQQARVILSRQSTREQVGAAFTALRAYLDTLVEEKLHTPGDDLTSRLATEH
LEPTGDVRRQDLVASCMLLLTAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEA
VEELVRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDI
HRGNRRHACFGYGVHQCIGQHLARTELEVAFSTLFTRIPTLQIAAPSDELDYDHDGML
FGLHELPVTW

>CYP105X2 AF071148  Amycolata autotrophica cytochrome P450 66% to 105S2
LLIAGHETTSHMISLGVTALLERPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL

>CYP105X3 AF071146  Micromonospora inyoensis cytochrome P450 1 diff to 105X2
LLIAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL

>CYP106A1 X16610 BM-1 Bacillus megaterium
MNKEVIPVTEIPKFQSRAEEFFPIQWYKEMLNNSPVYFHEETNT
WNVFQYEHVKQVLSNYDFFSSDGQRTTIFVGDNSKKKSTSPITNLTNLDPPDHRKARS
LLAAAFTPRSLKNWEPRIKQIAADLVEAIQKNSTINIVDDLSSPFPSLVIADLFGVPV
KDRYQFKKWVDILFQPYDQERLEEIEQEKQRAGAEYFQYLYPIVIEKRSNLSDDIISD
LIQAEVDGETFTDEEIVHATMLLLGAGVETTSHAIANMFYSFLYDDKSLYSELRNNRE
LAPKAVEEMLRYRFHISRRDRTVKQDNELLGVKLKKGDVVIAWMSACNMDETMFENPF
SVDIHRPTNKKHLTFGNGPHFCLGAPLARLEMKIILEAFLEAFSHIEPFEDFELEPHL
TASATGQSLTYLPMTVYR

>CYP106A2 Z21972 P450meg Bacillus megaterium
MKEVIAVKEITRFKTRTEEFSPYAWCKRMLENDPVSYHEGTDTW
NVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSL
LAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIVASLASPLPIIVMADLMGVPSK
DRLLFKKWVDTLFLPFDREKQEEVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDL
LKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDL
VPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFT
LNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEENLT
DSATGQTLTSLPLKASRM

>CYP106B1    Bacillus anthracis str. Ames Genpept AAP26480                 
1 MASPENVILV HEISKLKTKE ELWNPYEWYQ FMRDNHPVHY DDEQDVWNVF LYDDVNRVLS
 61 DYSLFSSRRE RRQFAIPPLE TRININSTDP PEHRNVRSIV SKAFTPRSLE QWKPRIQSIA
121 NELVKDIENC SEVDIVEQFA APLPVTVISD LLGVPTTDRK KIKAWSDILF MPYSKEKFND
181 LDAEKGIALN EFKAYLLPIV QEKRYHLTDD IISDLIRAEY EGERLTDEEI VTFSLGLLAA
241 GNETTTNLII NSFYCFLVDS PATYKEVREK PKLISKAVEE VLRYRFPVTL ARRITEDTNI
301 FGPLMKKDQM VVAWVSAANL DEKKFSQASK FNIHRIGNEK HLTFGKGPHF CLGAPLARLE
361 AEIALTTFIN AFEKIALSPS FNIEQCILEN EQTLKFLPIR LKPQ

>CYP106B2P  Bacillus cereus ATCC 14579 GenPept AAP09572  GenEMBL AE017006
1 MTSVITDGEI VTFSLGLLAA GNETTTNLII NSFYCFLVDS PGIYEELRKE PNLILKAIEE
61 VLRYRFPVTL TRRITALSER ESPSPLGMG

>CYP106B3P  Bacillus cereus ATCC 14579 GenPept AAP09575 GenEMBL AE017006
LKEDTNIFGPF
 1 MKKNQMIVAW VSAANLDEKK FSQASQFNVH RTGNEKHLTF GKGPHFCLGA PLARLEAEIA
61 LTTFINAFEK IELFPSFCLE KCILENEQTL KYLPIRLKAT

>CYP107A1 X60379 Saccharopolyspora erythraea
MTTVPDLESDSFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTG
YDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLR
KLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELLGVD
EKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRV
QDDDDGRLSADELTSIALVLLLAGFEASVSLIGIGTYLLLTHPDQDQLALVRRDPSAL
PNAVEEILRYIAPPETTTRFAAEEVEIRGVAIPQYSTVLVANGAANRDPKQFPDPHRF
DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSL
LLRGIDHLPVRLDG

>CYP107A2   Streptomyces rochei plasmid pSLA2-L NC_004808 complement(44847..46067)
MTTDAHTAVPSLDSDLFHIDQYEAYAALREREPVSKVSFIGREA
FLITRHAEAKAALGDLRLSNDFKKQPPGVELPTYHGIPEDVRPYFANNMGSNDPPAHT
RLRRLVSREFTARRVESMRTRVAQLAEHLLDGLAGERETDLVERFAYPLPITVISELL
GVEERYQGDFGRWSNEFLVIDADRVEQREHAARALVGFILELVDRRRADPGSDLLSAL
IHVHDEDEDRLSTDELASVVLILLIAGFETSVSLIAMATYLLLTHPGELAKVRADPSL
VPNAVDEVLRFLGPAEITTRGTLEPVEIGGVHIPAHSTVLIAGAAANRDPRRFPDPER
FDVTRDTGGHLSFGHGIHFCVGGPLARLEGEIALRALLNRFPGLDLAIPAEQVRWRRS
FLRGIESLPVRLGR

>CYP107B1 M83110 Saccharopolyspora erythraea
MTTGEVPDLLAFDDAFAQDRHNRYARMREEPVQRIRTVNGLDAW
LITRYEDVKQALLDPRIAKDFGRTQQIIEKRLADAERRPGFSPDLGPHMLNTDPPDHT
RLRKLVVKAFTARRVEGLRPRIEQITDDLLDRLAGRSEVDLIDEFAFPLPITVISELM
GVEDSRRDDFRSWTNVLVDGSQPEAQAQASVAMVEYLTELIAKKRTEPGDDLLTALLE
AVEDGDRLSEGELIAMVFLLLVAGHETTVNLIGNCVLSLLGNPDQLAALRNDPSLLPG
AIEETLRYESPVANGTFRHTAEAVRFGDVVIPEGELVWVALGAANRDGERFEDPDRFD
ITRETTGHVAFGHGIHFCVGAALARLEAQIAVGRLLERFPDLRMAASPDDLRWRFSVL
MRGLEKLPVRPGA

>CYP107B2   Streptomyces sp. GenEMBL BD133548 58% to 107B1
3   LIAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDSPVGIATFRFSTE 182
183 ALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFGFGMHHC 344

>CYP107C1 D30759 Streptomyces thermotolerans
MTALNLMDPEVLRDPFGAYAEIRAQAPLVRASYPWGAVQWLATR
YSDVKAVLTDPRLVNNPANVPEMHLPHPYEQALGDGGIPDEYVRYLAGSILSQDGPGH
LRLRRLSSRAFTVRRVNALRPRVTELAHRLLASLPDRAQDGVIDVLEDFSYPLSIDVI
CEIVGIPEEAREQWHTWGSAFYTMDPAVIGPAVRGMADHLHLLIEQRRATPTGDLLTG
LVQAEDEQGEPLTDEEIATLVLTFVTAGNETTAHLIGNGVAALLTHSDQLALLRSDRR
LLSQAVDELMRWCTPVQVTQPRYATEDLDVGGVTVRKGEQVVAVIGAAGHDPDRFPDP
ERFDITRNHRAPHEAHVGFGFGPHYCLGAALAHQETAIALDTLFDRFPSLALAVPPSA
LERQPFPGAWRLKSLPVRL

>CYP107D1 L37200 Streptomyces antibioticus
MTDTHTGPTPADAVPAYPFSLPHALDLDPHYAELRRDEPVSRVR
LPYGEGTAWLVTRMSDARIVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHT
RLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICEL
LGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLGA
LALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVADPAL
VPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHA
DELDFHRERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWK
QGMLIRGLERQIVSW

>CYP107E1 D16098 Micromosospora griseorubida
MTSAEPRAYPFNDVHGLTLAGRYGELQETEPVSRVRPPYGEEAW
LVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAF
TARRAESLRPRAREIAHELVDQMAATGQPADLVAMFARQLPVRVICELLGVPSADHDR
FTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDS
LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELIPSAVEELTR
WVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN
QHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLE
LPVVW

>CYP107F1 AB018074  Streptomyces griseus CDS 341..1561
MENTSVQNKETVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMA
YGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSR
LRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPGDFVARVSAPLPLITICEAL
DIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTL
ATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRL
PRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPD
ELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNT
TSIWRYPLALPVTW

>CYP107F2 SAV1171 AP005025 Streptomyces avermitilis
MTPSDEAIMCPFDFSKGLEFDPSLAELMARDSITRIRLPYGDAD
AWLVTGFDAVRQVTTDQRFSRAGIMGSDYPRLTPEPIVSPESINVVDPPHSSRLRRLV
SQAFTKGHVERMRRRIVRLADTLLDEMAAQGPPADLAHHLSNRLPQHTICDVLGIEQD
DWPRMEQYVHQLLSTGPDSRQSAATAKSELREYFGGLVEKRRSSPGNDLISALAAAKD
GEDVLDDQELAVMALTLMLSGHDTATCQISNICYLLLTRPELMKHLRSRPDTLTAVLN
EMLRFIPFRKGVGIPRVAVEDAEVDGVKIRAGDFVHVSYLTANRDPERYPDPDAIDPD
RPSLPHMTFGWGGHRCIAVPLAMAELEVAIGRLLERFPELRLAVPPEEVRWDTETIRR
FPIELPVAW

>CYP107G1 rapN X86780 Streptomyces hygroscopicus
MSTTDQGETGKACPYPFAEMERLEIHPEYNRLRDAGELGRVLML
DGREAWLAASWEDVAKVFVDPRFSRSATLGKDVPRVLPAIQDQPVIMLMDPPEHTRLR
RVATKALTSRRMEALRPRTQEVADDLIDKMLAKGAPADLMEDFALPLPIIMICELLGV
PIEDQTKFRTWSDQMLSNGAYSQEVVMAAGQSLYLYLSELIAERRKQDTNDLLGSLVR
ARDKDDRLSETELVGFAVTLLIAGYETTANAIGNSVYTLLTHPEKLAELRKDLSLIPK
AVDELLRIIPIAKQASWVRMAVEDVELSGTIVKAGEAVAIQTHSANTDPKVYDHPEEI
DFHRTSNPHMSLGHGAHHCMGAQLVRVEMQTALGSLISRIPALRFAVPEPRIKFLRGR
LVPSLEALPLTW

>CYP107H1 BioI U51868 Bacillus subtilis
MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG
YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP
RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE
WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD
KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL
RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP
HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV
TFE

>CYP107J1 cypA Y11043 Bacillus subtilis
MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL
GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP
DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS
EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD
LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ
QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF
PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM
KWKGNFLMRALEELPISF

>CYP107J2  Bacillus anthracis str. Ames GenPept AAP26475
1 MAMKNKVGIR IEDGINLASA QFKEDAYEIY KESRKVQPVL FVNKTELGAE WLITRYEDAL
 61 PLLKDNRLKK DPANVFSQDT LNVFLTVDNS DYLTTHMLNS DPPNHNRLRS LVQKVFTPKM
121 IAQLEGRIQD IADDLLNEVE RKGSLNLVDD YSFPLPIIVI SEMLGIPKED QAKFRIWSHA
181 VIAYPETPEE IKETEKQLSE FITYLQYLVD MKRKEPKEDL VSALILAESE GHKLSARELY
241 SMIMLLIVAG HETTVNLITN TVLALLENPN QLQLLKENPK LIDAAIEEGL RYYSPVEVTT
301 SRWADEPFQI HDQTIEKGDM VVIALAAANR DETVFENPEV FDITRENNRH IAFGHGSHFC
361 LGAPLARLEA KIAITTLFER MPELQIKGNR EDIKWQGNYL MRSLEELPLT F

>CYP107J3   Bacillus cereus ATCC 14579 GenPept AAP09568            
1 MKNKVGLSIE DGINLASAQF KEDAYEIYKE SRKKQPILFV NQVEIGKEWL ITRYEDALPL
 61 LKDNRLKKDW TNVFSQDIKN MYLSVDNSDH LTTHMLNSDP PNHSRLRSLV QKAFTPKMIA
121 QLDGRIQRIA DDLISDIERK GTLNLVDDYS FPLPIIVISE MLGIPKEDQA KFRIWSHAVI
181 ASPETPEEIK ETEKQLSEFI TYLQYLVDIK RKEPKEDLVS ALILAESEGH KLSARELYSM
241 IMLLIVAGHE TTVNLITNTV LALLENPNQL QLLKDNPKLI DSAIEEGLRY YSPVEVTTAR
301 WAAEPFQIHH QTIQKGDMVI IALASANRDE TVFENPEIFD ITRENNRHIA FGHGSHFCLG
361 APLARLEAKI AITTLFNRMP ELQIKGNREE IKWQGNYLMR SLEELPLTF

>CYP107J4P  Bacillus cereus ATCC 14579 GenPept AAP09593                 
1 MKEPQLQQHL EKFIQYIEAL VNEKRLNPDA DLISELVQTK EQEDKLSNNE LLSTIWLLII
 61 AGHETTVNLI SNGLLALLQH PEQMNLIREN PSLIPSAVDE LLRHSGPVMF ISRLASEDMT
121 IHGKRIPKGD LVLLSLTAAN IDPQKFTYPE TLNISREENN HLAFGAGIHH CLGAPLARLE
181 GQIALGTLLQ RLPNLRLAIK PDQLNYNHSK IRSLVNLPVV F

>CYP107K1 Z99113 Bacillus subtilis gene="pksS" 43% to 107J1
MQMEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATY
PAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHT
RLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELM
GIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKL
VHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMI
ATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEI
LNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKAAFEEIS

>CYP107L1 AF087022  Streptomyces venezuelae cytochrome P. = pikC gene AF079139
MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTR
LRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISEL
LGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALV
RTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLL
DGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHR
FDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPN
PMIRGLKALPIRWRRGREAGRRTG

>CYP107L2 SAV1987 AP005029 Streptomyces avermitilis
MGNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEG
WLVVGHEEARAALADPRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAF
TMRRVEALRPRIQEITDGLLDEMLPRGRADLVDSFAYPLPITVICELLGVPDIDRVTF
RALSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAEDDDRL
SGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDGAVEEVLRF
EGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHRAPQGH
LAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW

>CYP107L5   Streptomyces sp. GenEMBL BD133547 68% to 107L2 
3 LIAGHETTVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAE 182
183 PLEIGGTVIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGFGTHRC 344

>CYP107L6   Streptomyces sp. GenEMBL BD133544 72% to 107L2
MGHEHVIDLGEYGPGFTENPHPVYAELRARGPVHRVRLPKHDAHHEAWLVVGYEEARAAL
ADPRLSKDGSTIGVTFLDEELIGKYLLIADPPQHTRLRGLIAREFTGRRVERLRPRVQEI
TDSLLDEMLPRGRADLVESFAYPLPLTVICELLGVPEIDRAAFRKLSTEAVAPTSGESEY
AAFVQLAAYLEELVEEKRCAPPADDLLSALIRTTDEDGDRLSPAELRGMAFILLIAGHET
TVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAEPLEIGGT
VIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGHGIHFCLGAPLARLEARVA
LRALLERCPGLTPDGAPGEWLPGMLIRGVRSLPVRW*

>CYP107L7P   Streptomyces narbonensis GenEMBL AF521878  13901..14661
MSRTHQGTTASRPVLDLAALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDTARAVLADPRFSKDWRNSATPPTEAEAALSHNMLESDPRCGPT
ALRADLTLLDGAVEEMLRYGGPVESATYRFPVEPVDLDGTVLPAGETVLVVLAD
AHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCTGAPLARMEARIAVRALLERCPDLALD
VSPGELFWYPNPMIRGLESLPIRWRSGREAGRRVPVEPACRP*

>CYP107L8   Streptomyces sp. HK803 GenEMBL AY354515 complement(72672..73871)
MVTVDLSAYGPGFFTDPYPYYARLREAGPVHEIVLADGDRFWLI
VGYDEARAALADPRLAKSLDPPSEDERHVLITDPPDHTRLRRLVSREFTARRVEAMRP
RVQEITDGLLDEMVAGRRRADLVPSLGSPLPITVLCELLGVPLADREDFRGWTERVLV
PAEPDTIAWWKSRGFAQAGMALTDYLKNMIEDKRRSTPTGDLISSLLRTTAEDNDRLS
AAELHSMVFILIVAGHETTANLITNGVRALLAHPEQLAALRTDPEGLIDQAVEEMLRY
DGPVETSTKRFTLEAVRYGATKIPPGETLLVSIAATGRDPAQFERPDTFDIHRGTTGT
RSGHVAFGHGIHFCLGAGLARMESRVAILTLLRRCPDLALDIDPAGLDWLPGIRVRGV
RSLPVRW

>CYP107M1 D87924  Actinomadura hibisca polyketide synthase CDS 
MPSSKDAPTVDPRPDVTPAFPFRPDDPFQPPCEHARLRASDPVA
KVVLPTGDHAWVVTRYADVRFVTSDRRFSKEAVTRPGAPRLIPMQRGSKSLVIMDPPE
HTRMRKIVSRAFTARRVEGMRAHVRDLTSGFVDEMVEHGPPADLIAHLALPLPVTVIC
EMLGVPPEDRPRFQDWTDRMLTIGAPALAQADEIKAAVGRLRGYLAELIDAKTAAPAD
DLLSLLSRAHADDGLSEEELLTFGMTLLAAGYHTTTAAITHSVYHLLREPSRYARLRE
DPSGIPAAVEELLRYGQIGGGAGAIRIAVEDVEVGGTLVRAGEAVIPLFNAANRDPEV
FADPEELDLGRTDNPHIALGHGIHYCLGAPLARLELQVVLETLVERTPALRLAIDDAD
ITWRPGLAFARPDALPIAW

>CYP107N1 AF127374  Streptomyces lavendulae LinA homolog 
MTGPEAAVRGCPFGAGEAPAYPFHAPDRLEPDPYWEPLRRERPL
QRVTLPYGGEAWLATRYQDVRAVFADRRFSRQLAVAPGAPRFLPHQPPPDAVLSVEGP
DHARLRRLVGKVFTPRRVEDMRPLIQRTADGLLDAMEEMGPPADLVEDFSLPFAVSMI
CELLGVPPEDRKRFCVWSDALLTTTAHTPAQVRDYMMQMHDYLGGLVAQRRVRPTADL
IGSLVTARDEEDKLTEGELVRLAEAILIAGYETSASQIPNFLYVLFRHPQLLERIRND
HDLIPDAVEELLRFVPIGTVDGFPRTATEDVELGGVLVRAGETVVPSMGAANRDPELF
TDPDELDLARRPNPHLGFGAGPHHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESL
SWKEGLMVRGMHTMPVTW

>CYP107P1 AL049754.1 Streptomyces coelicolor cosmid H10 CDS 
MTAATDGPHVSGPAFDPWDPAFVADPYPAFAELRARGRVLYYEP
SDQWLVPHHADVSALLRDRRLGRTYQHRFTHEDFGRTPPPPEQEPFHTLNDHGMLDLE
PPDHTRIRRLVSKAFTPRTVERLKPYVHGLADDLVARLVAAGGGDLLTDVAEPLPVAV
IAEMLGIPESDRAPLRPWSAEICGMYELNPSEETAAKAVRASLDFSDYLRALIAARRK
EPGDDLISGLIAAHDEDDRLTEQEMISTCVLLLNAGHEATVNATTNGWLALFRHPDQL
AALRADHSLVPSAVEELMRYDTPLQLFERWVLDEIEIDGTTLPRGAEVAMLFGSANHD
PAVFTDPERLDLTRRDNPHISFSAGIHYCIGAPLARIELAASMTSLLKRAPGLRLAAE
PERRPNFVMRGLTELRVEL

>CYP107P2 SAV4539 AP005039 Streptomyces avermitilis
MAAAFDLAFDPWDPAFLADPYPAYADLRAKGRVHYYEPTNQWLV
PHHADVSALLRDRRLGRAYQHRYTHEDFGRTAPPAEHEPFHTLNDHGMLDLEPPDHTR
IRRLVSKAFTPRTVEQLKPYVAKLAGELVDRLVAAGGGDLLADVAEPLPVAVIAEMLG
IPESDRAPLRPWSADICGMYELNPPKDVAAKAVRASVEFSDYLRELIAERRKEPGDDL
ISGLIAAHDEGDRLTEQEMISTCVLLLNAGHEATVNATVNGWYALFRNPDQLAALRAD
HSLVPAAVEELMRYDTPLQLFERWVLDEIEIDGTTVPRGAEIAMLFGSANHDPEVFRN
PEKLDLTREDNPHISFSAGIHYCIGAPLARIELAASMTALLEKAPTLGLVAEPKRKPN
FVIRGLEGLSVAV

>CYP107Q1 AF040571  Amycolatopsis mediterranei thioester 
PVPLSIVSRDRVSIQRLACKVFGETRSGPPGRASFVLIAPRRPQ
TVHKGHNSEHCQVGGCSTGRPLPTVRNRACRTRAGRPRRHQEGMAMTATAKPSAKPVD
LFSPEVVADPFGWYARLREEPLPHTGTLNLGTMMGGPDMWLATRYEDVLTVLTDPRFL
TNPPADSPLADIRDGVFKAMNFPEDLIPWMANKLNTADGEDHTRLRKLVSYALTARRV
NALRPRVEKITEDLFDRMAEQGKDGSPVDIVEEFCFPLPVTVICELVGIDEPDRAAWH
AWGNAMATMDGPKIPPALRECIALSRELMARRRVEPKDDLVTALVQAQADDPGRVSDD
EIVGILFSLVTAGHQTTTYLIGNSVLFLLEQPEQLARLKAEPALWAQAVRELQRLGPL
QFTQARFPSEDVELGGVTIPRGTPVAPLLLAANTDPRKFPEPDKLVVDRLSVANEMHL
SFGKGIHRCLGQHLAYQEAEVALHGLFTRFPDLALAVPRDEIPWILRPAFTRTKTLPL
KLA

>CYP107Q2 AF040570  Amycolatopsis mediterranei rifamycin 
MTTTAETSAEPVDLFSPEVVADPWGAHAAVREAPTLQIGGFMGG
PPMYLAARYEDVRQVLMDQRFQCNPLADSPAEDIRNGVFRHLDMPEELIPWLKNLINA
SDGEEHARLRKLVSYALTAHRVGKFRPRVEELTAELLDKLEAAGGDGTPIDLVESFCY
PLPVTVICELVGVDHEDRPQWRAWSDAMATLDGKRLPEEVRKTLAAARGMIERRRAEP
KDDMVTALVEAQAKNPGIATDDELVGVLFSLVTAGHQTTTYLIGNSVLALHEHPDQLA
RLKADPSLWPQAVRELQRLGPIQFGQPRFATEDIEVGGTVIPRGMPVVPLIMAANSDP
RKFPEPEKLQIDRLAVGSESHLGFGKGIHRCLGQHVAYLEAEVALRGLYTRFPDMTLA
VPREEIPWILRPGFTRTKDLPVRLARPAS

>CYP107R1 AF254925  Streptomyces maritimus enterocin 
MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGE
AWLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVA
GVFTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDD
REQLRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDR
EEGLLRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVE
ELLRFIPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDID
RSPNPHVAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVR
GPKTLPVKW

>CYP107S1 NZ_AABQ07000001 Pseudomonas aeruginosa 
VPDRKLRLGEELISPLHALYDGLQVDGAPRPAHRAAEHPVWVVTRYRDAR
KVLNHPGVRRDARQAAELYAKRTGSPRAGIGEGLSHHMLNLDPPDHTRL
RSLVGRAFTPRQVERLQPHIERITEALLDAMAGREQADLMADFAIPLTI
AVIFELLGIPEAEREHARQSWERQAELLSPEEAQALADAQVDYLRVLLE
AKRRQPADDVYSGLVQAADESGQLSEAELVSMAHLLMMSGFETTMNMIG
NALVTLLVNPEQLALLRAQPELLPNAMEELVRHDSPVRASMLRFTVEDV
ELDGVTIPAGEYILVSNLTANHDAERFDDPDRLDLTRNTDGHLGYGFGV
HYCVGASLARLEGRIAIQRLLARFPDLQLAVPHAELQWLPITFLRALIS
VPVRTGCSAPANTASHANPIERIAQ*

>CYP107T1 Streptomyces coelicolor AL442629.1 SCH63 16028-17233
16049 MGSAPRLIVSLTGGPMTAPTYEELAALRAVGAVHRVFVPGSGESRLVVTRDAARAALTDPRL 16234
16235 RNDIRHSASWDSDGGHAIGHNMLQSDPPQHTRLRRLVAGHFTPGRTAALRPRVERIAHDL 16414
16415 LDALPPAGTADLVARYALPLPVTVICELLGVPESDRGTFHTWSNELVMPTSPEAAGSA 16588
16589 ATALTGYLTELTDAKRRTPDGTLLGDLVAAADSGELTPGELLGMAFLILVAGHETTVN 16762
16763 LISATVHGLLTHPGQLARLRAEPELTEAAVEESLRYHSPVHASAFRFAAEPLELAGTAIA 16942
16943 AGDPVLVSLAAASRDPAHFPDPDRFDIGRRPRGHLGFGHGPHHCLGAPLARVEAAVAVRL 17122
17123 LLDRHPALALAAGPATLTWRTSTLLRGLVELPVRLG* 17233

>CYP107U1 AL442120.1 SCE41 Streptomyces coelicolor cosmid E41
8739 MTGSSSAPVPELFSWEFASDPYPAYAWLREHAPVHRTRLPSGVEAWLVTRYADAKQALADP 8557
8556 RLSKNPAHHDEPAHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEF 8377
8376 APRVQELADGLIDRFADTGSADLIHDFAFPLPIYAICDLLGVPREDQDDFRDWAGMMI 8203
8202 RHQGGPRGGVARSVKKMRGYLADLIHRKRAALPPEPAPGEDLISGLIRASDHGEHLTEN 8026
8025 EAAAMAFILLFAGFETTVNLVGNGTYALLTHPEQRERLQTSLAAGERGLLETGVEELLRY 7846
7845 DGPVELATWRFATRPLTIGGQDVAAGDPVLVVLAAADRDPERFTDPDTLDLARRDSQHLG 7666
7665 YGHGIHYCLGAPLARLEGQTALATLLTRLPDLRLAADPAELRWRGGLIMRGLRTLPV 7495
     SFTPPASSAGNGPSPTQK*

>CYP107U2 SAV3536 AP005035 Streptomyces avermitilis
MAGSARRRGRHGGGVGTVAGSAAGTRRLQRERGSRYRHPVNAPH
SEPELFTWEFATDPYPAYAWLREHAPVHRTTLPSGVEAWLVTRYADAKQALADARLSK
NPVHHSEDAPGKSKTGIPGERSANLMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAP
RVQELTDHLIDQFAQTGSADLIHEFAFPLPIYAICDLLGVPREDQDDFRDWAGMMIRH
GGGPRGGVARSVKKMRGYLAELIHRKREALPADPGPGEDLISGLIRASDHGEHLTENE
AAAMCFVLLFAGFETTINLIGNGTYALLRNPQQRARLQQSIERGEQDLLDTGIEELLR
YDGPVELATWRYATEPLDMGGQRIASGDPVLVVLAAADRDPARFDEPDTLDLSRSDNQ
HLGYGHGIHYCIGAPLARLEGRTALATLLRRLPDLRLAADPADLRWRGGLIMRGLRNL
PVEFTAT

>CYP107V1 SAV3519 AP005035 Streptomyces avermitilis
MSGASARCPFSGAGGGTDVLPLPADPGTAAGAPAPGPPDAPAAP
APRTADRSAPHAADPHAPSTADLPRFPFPGLSGIPLDPVLLDRYRGEPLVPVGLANGR
EALLVTRYADVRTVLSDDRFSREAWANGTLFARRSGALALVTSDAPTHTRRRSRVQSR
FTHRRAEEDRPRIARIAAELLDSLQAADTGRPVDLIAEFTTPFPYRVICEMLGVPVAD
LDRLLPSVTVMMSAGRFSADEAARAHEVMYGYFFGQLAARREAIAAGCPGDDLLTSLL
SAPRETRLSDEEIVVFGFGLMMAGGETTASHLAMCVLQVLGTPGLADRLRRDASAVPA
VVEELLRWVWFAGTGGQPHVALEDVELAGRVLPAGQVVIPLTDAANRDPGVFPDADEF
RPDRAPNPHIGFGHGRHMCLGAAHARVELQEGLTAVLERLDHLELAVEPAELRWRDQM
FMRGVWELPVRWHTKEDGRC

>CYP107W1 SAV2894_olmB AP005032 Streptomyces avermitilis
MAEAPSEPIAFPFPDPPSVCELPPELAEIRDGQSVVEVKFPDGI
SGWMVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRK
LVTKAFTARRVETLRPRITELVGQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVP
AGDQDTFHAWSNALLGDWQQVVEKEAATVSLVNYFGELIAVKRENPADDLISELIAIS
DGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRDNREAIPKAV
DELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL
NVTRENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSAS
IIRGLESLPITW

>CYP107X1 SAV6249 AP005046 Streptomyces avermitilis
MDPAEGLLADPYAVYDRLRDTAPVHRIAGTDGKPAWLVTRYDDV
REGLANPLLSLDKKHALPGNYRGLALPPALDANLLNMDAPDHTRIRRLVGRAFTLRRV
EQLREPVRETAHRLLDALGTHGSTDLIASYAAPLPITVICDLLGVPDEHRRDFRAWTD
PLVTPDPARPDVARESVVSLLGFFTGLLADKRKNPADDLLSDLIAVQEEGDRLTEDEL
MSLAFLILFAGYENTVHLIGNAVLALLRHPEQLAALREDPARLPDAVGEFARYEGPAL
LAIRRFPVRDVTIGGVTVPAGETVLLSLSAANRDPSRFPDPDRLDLGRDAAGHLALGH
GVHYCLGAPLARLETEVALAALLERFPDLALAETEPRRRPSLRARGLLALPVTY

>CYP107Y1 SAV2377 AP005030 Streptomyces avermitilis
MDFGADPYPEYAWLRAEEPVRQVLEGRGLYGLLVTRYEDVRKLL
SDPRMSKDPRNAPLDWQEAGKGRPLEDRTGLGTHLLTTDAPEHTRLRRLVSTAFTARR
VEGLRAQVQHITDGLLDTIVPRGQAELIGDFAFPLAITVICELLGVPKADQDVFRQWT
KDFRRWTNTDSAQADRGDARPVGLRDLLEYLTRLVDKRRQDPADGLVDALIAARDDDD
RLNEAELLSMMSLLLVGGFETTVNLIGNGTLALLRHPDQLALLRERPELVDSALEEML
RYDGSFETATWRFPLEPIEVAGTRIEKGHPVLLSLASANRDGAKFPAPDDFDVTRADP
AHVAFGRGAHFCLGAPLARLEGRIAFHGLLRRLPGLALSVPPEQLRWQRSLTVRGLEA
LPVTFDA

>CYP107AA1   Mycobacterium smegmatis MSMEG3142 TIGR 
MTPYSRRDRNH
MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLT 
DPRIGKDGAAASALFPPGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAF 
TAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELL 
GVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPAD 
DVLSSLVHRRDGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRN 
PEQLRAVRADRSLLPRAVEEALRFESPLNTATVRYTSAPVTVGDVEIPSG 
ELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM 
EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIAS 
TMREWSGSLPSSGEADSSFAH

>CYP107AB1P    Mycobacterium smegmatis
MILDEQFAQDPEGLYRMLRSEAPVCEVELIGGVRGWLVTRYADVMALLKD 
PRVSKDHTSALPRLAPDRVRPYISPQLHNHMLNLDPPEHTRLRRLVVQAF 
TPKALARMQPVIDAIADELLDDIDLRSGDEPIDLMADYAEPLPIQVIAEL 
LGVAVEYA*PFRAAVTPLLMSVTVEEKAESGRATIEILNAVIDEKIREPG 
EDLLSGMIGASVDGHGLTRDELMAMCFLLITAGYETTVNLIGNGTLALID 
NPSQLEKVRENPDLTAGAVEEILRFDGPVNIATWRYATADIDVDGVVIPA 
NEQIFLSLLSANRDTGRFENADRFDIERNTRGHIAFGHGIHYCLGAPLAR 
MEGVTAIGRIVQRYDSITLDPTAELRYHNGTLMHGLKSLPVRLTRVPQPRP

>CYP107AC1   Streptomyces atroolivaceus GenEMBL AF484556 60948..62147
MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGE
GWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSK
AFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDR
GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD
DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEEL
LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITRE
KNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGP
QRLPIAW

>CYP107AD1   Streptomyces hygroscopicus GenEMBL AF521896 4248..5489
MSGRHFEQGERGTAMADTPEEELRILDPQSVAQELRKHGPPRQI
TMHGTTAWLVSRYEEVRDCLGHPGMSPAAAYAASQGQTNPVSGLFEDTVAGTNPPQHT
RLRRLLAKAFTVRRVESLRPRVQEITDTLLDRIAVDGRADLVSALAIPLPMQVICELL
GVPIADRTEFHQWADLMLTPPLDPDTAARSQDASAKLWTYMEDLAEARRKAPEDDLIS
DLMSAHEDDRLSHREVVATARMMLIAGYELTGSFISNAVFSLLSQPDQMELLRKDPEL
AGRGLEELLRHAGPGILIVRFANEDVEIGSVSIRAGDQVLLDMDAAHSDPAHFTDGER
LDLTRDSAVHLQFGHGIHYCIGAPLARVEGQIALESLVRRFPGLRLSVPAAEISHSKN
PFIRSLTALPVEFEAQQPVAG

>CYP107AE1   Streptomyces sp. GenEMBL BD133545 50% to 107X1
VILLKSLAANGLTASSCFTVSPLPIRSASPSIAFLTSSSERDSGVRNDRPSDAQPAIARF
RFPTPPHPRNPTQPHPTPPRPSPTDDPLQAPTFFADPYPTYARLRDTAPVLKVPTGSGGG
GRHSYVVTGYAEAREAFTDPRLSKDTASFFAGRPSQRDLHPAVSRNMLATDPPQHARLRA
LVTKAFTTGAVARLRPYISSLVDELLDTWPTHGTVDLIADLAVPLPVTVICELLGVPDSD
RASVRTWSSDLFAAGDPQRIDAASHAVGDYMTALVAAKRTAPGDSLLDDLIAVRDGQDHL
SEDELVSLAVLLLVAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDS
PVGIATFRFSTEALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFG
HGIHRCLGAPLARAEAELALHAVITRYPQAALATPPETLPWRHTRLTRGLASLPITLRDH
PK*

>CYP107AF1   Streptomyces collinus DSM2012 GenEMBL AF293355 24259..25518
MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPN
GLRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPH
VLSVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLME
ALAFPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEA
KRNEPADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHP
EVREQLAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGA
AGRDPDRYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLR
LAADPDELSWRSSLMMRGLEELPVFTA

>CYP107AG1 Streptomyces atroolivaceus GenEMBL AF484556 complement(120436..121638)
MSTEVETEKPAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLP
FGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRT
LVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVP
EDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIEA
RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIPAA
VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV
IDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEWKADMIIRA
PRVMHVEW

>CYP107AN1   Bradyrhizobium japonicum USDA 110 GenPept BAC51802                 
1 MVTPGSGAAI GVFVSCGNRF EVTMNEQAQP AGGDPLFNPL SPDFIRNPYP HYDRLRAIDP
 61 IHVTPFGQFV ASRHADVSLV MRDKRFGKDF VERSKRRYSE KIMDEPVFRS MSHWMLQADP
121 PDHTRLRGLV VKAFTARRVE DMRPRIQEIV DEAIDAVIDR GHMDLIEDFA FRLPVTIICD
181 MLGIPEDHRE VFYKSSRDGG RLLDPVPLTP EEIAKGNAGN MMAQMYFQQL FELRRRNPAD
241 DLTTQLVQAE EDGNKLTNEE LTANIILLFG AGHETTVNLI GNGLLALHRN PDQLALLKAR
301 PELMVNAIEE FLRYDSSVQM TGRVTLEDID DLGGRKIPKG ETVLCLLGSA NRDPAVYPDR
361 PDRLDVTRPN VKPLSFGGGI HFCLGAQLAR IEAEIAIATL LRRLPDLRID DVENPEWRPT
421 FVLRGLKSLP ASW

>CYP107AP1   Streptomyces rochei plasmid pSLA2-L NC_004808 Links 87725..88939
MNQPQLPEIPALNSELFHTDQYATYREILEQRPVTRVRFYDGSL
VWLVNRHEDVRAALTDPRLSNDPMKQSDIDLSAATGIPADLIEYFQRNMFRSDEPDHG
RLRKLVTREFTVRRINALRPRIRQIADDLLEKFAATGGGDLVEALARPLPLTVMCELL
GVPEEDRADFQTWSQHIVESSPEFAERNAVSYRSLFECVRSLIRRRRDEPGDDLLSAL
VDLRDVADRLSENELISTVFLLLVAGIETTVNVLGTGTFLLLTHPGELARLRADGALL
GPAVEEMLRYMAPIEITSRHTLEPVEIGGVSIDAQSTVLINLAAANRDPARFEDPQSF
RVDRNDGGHLTFGHGIHYCLGAALARAEAEVTFEALLERFPDLRLAASASDLTWRHAF
MRGPVELPVSWG

>CYP108A1 P450terp M91440 Pseudomonas spp.
MDARATIPEHIARTVILPQGYADDEVIYPAFKWLRDEQPLAMAH
IEGYDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSL
TSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALY
YPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIAT
FYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS
GGAIIGLSRNPEQLALAKSDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKR
GDRIMLSYPSANRDEEVFSNPDEFDITRFPNRHLGFGWGAHMCLGQHLAKLEMKIFFE
ELLPKLKSVELSGPPRLVATNFVGGPKNVPIRFTKA

>CYP108B1    Mycobacterium smegmatis MSMEG1429 TIGR, 
MFLTPVKFSPSEVPD
MSTPVINDAARVLAEPRAYADEPRLHAALAELRSQTPVAYVDVPGYYPFW
AITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIRTLIH
MDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPECDFV
QEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSSAEEL
NAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGEYLNDVDCLSYYV
IVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMPLATEEIIRWSA
PVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEIFENADKFDVGR
DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEFMAT
TFVGGLKHLPIRYSVR

>CYP108B2    Mycobacterium smegmatis MSMEG1428 TIGR 
MSTPTMDDAAKALADPTAYADDARLHEALARLRAENPVAWVDQAPYRPFW
AITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGLRTLIH
MDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGPECDFV
TDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGTTVEEQ
MAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDGELMSDMDTLSYYV
IVASAGHDTTKDAISGGLHALIENPGELARLKADPGLMGTAVEEMIRWST
PVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSGNRDEEVFTDPFRFDVGR
DPNKHLAFGYGVHFCLGAALARMEMNSLFSELLPRLDSIELAGEPELSAT
TFVGGLKHLPIRYSIR

>CYP108B3    Mycobacterium smegmatis MSMEG2261 TIGR
MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFW 
AITRYADIMAIERANDLFTNSPRPVLMTAEEDEQQAAVGISTLIHMDDPQ 
HRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGGECDFVQEITV 
NYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALL 
EMFQYFTELTASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAA 
GHDTTSATISGGMLALLEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAF 
MRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH 
VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGG
LKHLPVRYALR

>CYP108B5   Mycobacterium avium subsp. paratuberculosis K-10. NP_961305, AAS04688.1, 
MSTTTMDEAA KLLADPMAYT DEQRLHAALT HLRANAPVSW VEVPNYKPFW AITKHADVMD
IERENMLFTN WPRPVLTTAE GDEMQAAAGV RTLIHMDDPQ HRVVRAIGSD WFRPKAMRAL
KVRVDELAKI YVDKMLAAGP ECDFVQEVAV NYPLYVIMSL LGLPEADFPR MLKLTQELFG
SDDSEFKRGS SNEDQLPALL DMFGYFNGVT AARREHPTED LASAIANARV DGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLQRLRDNL DLMPLATEEM IRWVTPVKEF
MRTAAKDTVV RGVPIAAGES VLLSYVSANR DEDVFDEPFR FDVGRDPNKH LAFGYGVHFC
MGAALARMEV NSFFTELLPR LKSIELTGDP ELVATTFVGG LKHLPVRYSL A

>CYP108B6   Mycobacterium flavescens PYR-GCK ZP_01192125.1, EAS11507.1 
MSVRVADEAG KVFADPTAYA DEQRLHAAMT HLRANAPVSW VDVEGYNPFW AITKHADIMA
IERDNTVFTN SPRPVLTTAE GDAQHASMGV STLIHMDDPQ HRKVRAIGAD WFRPKAMRAL
KVRVDELAKT FVDQMYDRGG ECDFVQEVAV NFPLYVIMSL LGIPESDFGR MLTYTQELFG
SDDAELQRGT TMEERGLALF DMFTYFNELT ASRRAQPTED LASAIANARI NGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLARLQQAP ELLPLAVEEM IRWVTPVKEF
MRTAQQDTEV RGVPIAAGES VLLSYPSGNR DEDVFTDPFR FDIGRDPNKH VAFGYGVHFC
LGAALARMEI NSFFSELLPR LTSVELAGRP EHIATIFVGG LKHLPIRYSL TR

>CYP108B7   Mycobacterium vanbaalenii PYR-1 ZP_01203876.1 EAS24868.1 
MSVRIADEAARVFADPSAYADEARLHAAMTHLRANAPVSWVEVPGYNPFWAITKHADIMAVERDNLVFTN SPRPVLTTAEGDAQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRVDELAKTFVDQMYERGG ECDFVQEVAVNFPLYVIMSLLGIPESDFQRMLTYTQELFGNDDAELQRGESMEERGLALFDMFTYFNEIT AARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIENPDQLQRLQQNP GLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKH VAFGYGVHFCLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR

>CYP108B8   Mycobacterium vanbaalenii PYR-1 ZP_01205329.1, EAS26321.1 
MSTPTMNQESQEAAKVLADPTAYADDQRLHKALAHLRANDPVAWVDHPPYRPFWAITKHADIMAIERAND LFLSEPRPVLVTAEADDMARAQLEAGFGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKIRVDELAKRY VDKMRDIGPECDFVTEIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGATVEEQMAVLTD FFNYFGALTASRRANPTDDLASAIANGLVDGELMSDVDTLSYYVIVASAGHDTTKDAISGGLHALVENPG ELARLQGDLDLMPTAVEEMIRWSTPVKEFMRTAAEDTTVRGVPIAKGESVYLAYVSANRDEDIFDDPFRF DVGRDPNKHLSFGYGVHFCLGAALARMEINSLFSELLPRLDSIELAGRPELSATTFVGGLKHLPVRYSLR

>CYP108B9   Mycobacterium vanbaalenii PYR-1  ZP_01205327.1, EAS26319.1 
MSTPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNE LWINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIY VDKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITD FFRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQD QLARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKF DVGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR

>CYP108D1   Novosphingobium aromaticivorans GenEMBL NZ_AAAV01000137
MTNTSRLTKRRRPRRSDGKREGFMDSIPMVPAEVGRAVIDPKSY
GTWEPLLDRFDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKST
VFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRK
IANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDE
DMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEP
MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPGIVEEAIR
WTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANRH
LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRW
KAA

>CYP108E1   Ralstonia metallidurans GenEMBL NZ_AAAI01000348
MTIASDFDTELASHEIYSDPERMHEMFETLRREDPVHWTTAPGH
PPFWAVTKQADVIEVGKHPDVFIASPKSFLMNDVEQRVRIEETAATGGKLVRTMIHMD
DPDHKKYRGLTQSYFMPANIKRLESVIQERARALVGRLIEKGTSEFCSEIAVWYPLQI
VMTLLDVPESEHPYLLKLTQQFLAPKDPTLRRDGPDERGKGAVAKEYFAYFGKMLAER
RAAPLKEDLGSLIAHATVDGEPLPLMEAVSYYVILATAGHDTTSSSMCSGLYYLLTQP
GELDRLRARPELMPSAIEEMFRHGSPVKHFVRTATRDFELRGKKIQAGDEVALMYHSA
SFDEEVFDEPRSFRIDRGPNKHVAFGFGIHACLGQNLARASMRTFFTELLARTESIEV
VGKAEFIASNQVGGMKTLNIRVTPSKQSTTDRIEVAA

>CYP108G1 Caulobacter crescentus AE005918
MTISTDIANTIIDPKAYADGDRIDQAFAHLRREAPLAVAQPDGF
DPFWVVTRHADILEVERQNELFHNGDRATVVTTIEPDKKVREMMGGSPHLVRSLVQMD
NPDHFAYRKITQGALLPQNLRALEARIREIARGFVDRMAEHGDRCDFARDVAFLYPLH
VIMEVLGVPESDEPRMLKLTQELFGNADPDLNRTGKSVTDVGEGVDSIQSVVMDFMMY
FNAITEDRRANPRDDLATLIANGKINGEPMGHLEAMSYYIIAATAGHDTTSSTTAGAL
WALAENPDQFAKVKADPSLIPGLIEESIRWVTPVKHFMRTATADAELGGQKIAKGDWI
MLSYPSGNRDEAVFEDPFTFRVDRTPNKHVAFGYGAHICLGQHLARMEMRVLWEELFA
RLDHVELDGAPTRMVANFVCGPKSVPIRFKMH

>CYP109A1 M24523 Bacillus subtilis
MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESP
VRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAF
TPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLI
KTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQ
AEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVAN
VIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKI
DRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFV
FGVKRLPVRITFK

>CYP109B1 YjiB Z99110 Bacillus subtilis
MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE
NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP
RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA
WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE
ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV
EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR
HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF
RVKM

>CYP110A1 U38537 Anabaena sp.
MLTQLPNPISVPSWWQLINWIADPIGFQKKYSKKYGNIFSMQLA
GIGSFVILGEPQALQEIFTQDSRFDVGRGNTLAEPLIGRTSLMLMDGDRHRRERKLLM
PPFHGERLQAYAQQICLITNQIASEWQIGQPFVARSAMQKLSLEVIIQIVFGLADGER
YQQIKPLFTDWLNMTDSPLRSSMLFLKSLQKDWGTWTPWGQMKHKQRSIYDLLQAEIE
EKRTKENEQRGDVLSLMMAARDENGQAMTDEELKDELLTILFAGHETTATTIAWAFYQ
ILKNVNVQEKLQQELDRLGANPNPMEIAQLPYLTAVSQETLRMYPVLPTLFPRITKSS
INIAGYQLEPDTTLMASIYLIHYREDLYPNPQQFRPERFIERQYSPSEYIPFGGGSRR
CLGIALALLEIKLVIATVLSNYQLALAEDKPVNVQRRGFTLAPDGGVRVIMTGKKSLK
FEQSSKIFN

>CYP110A2 U38478 Anabaena variabilis
MLTQLPNPISVPSWWQLINWIADPIGFQKKYSQKYGDIFSMQLA
GIGSFVILGEPQAIQEIFTQDSRFDIGRGNKLAEPLIGRTSLMLMDGDRHRRERKLLM
PPFHGEKLQAYAQQICLITHQIASQWQIGQPFVARSAMQKLSLEVIIQIVFGLANGER
YQQIKPLFTDWLNMTDSPLRSSMLFLKSLQQDWGNRSPWGQMKYQQRCIYDLLQAEIE
EKRTKENERRGDVLSLMMAARDENGQAMTDEELKDELLTILFAGHETTATTIAWAFYQ
IFRNVNVREKLQQELDSLGENPNPMEIAQLPYLTAVCQETLRMYPVLPTLFPRITKSS
INIAGYQLEPNTTLMASIYLIHYREDLYPHPQQFRPERFIERQYSPSEYIPFGGGSRR
CLGYALALLEIKLVIATVLSNYQLALAEDKPIKVQRRGFTLAPEGGVRMIMTGKKSLR
FEQSNKIFN

>CYP110B1   Nostoc sp. PCC 7120 Same as Anabaena GenPept BAB75445                 
1 MHLPKGPQTP VFVQVLRWVF SPMSFLEDCA KRYGDIFSVK LAKDVPAIVF LSNPKDIQQI
 61 LTNDNNQLDS PGDWNDLFEP LLGKRSVITL SGAEHQRQRQ LLMPPFHGER MRGYSQVITD
121 VTEKVISQHQ IGQPFQVRSV TQAITLRVIM QAVFGLYEGS RAEKLQHLLS DLLEKSSSPF
181 SVALLYFPSL RRDFGPIKFW GEQVQIQQQA DELIYQEIQE RRENPDPSRT DILSLLMDAR
241 DADGQPMTDV ELRDELMTLL VAGHETTATA LAWAMYWIHK LPPVKARLLE ELDSLGDNPD
301 STTIFKLPYL NAVYSETLRI YPVAMLTFAR RVIETMALGG YELPPGTPVL GSIYLTHHRE
361 DLYPEPKKFK PERFLERQFS PYEYLPFGGG TRRCLGLAFA QWEMKLALAK ILTSYELELV
421 NNSVEVRPKR RGLVTGPHRP IEMVIKSQRQ ITSRILETTT VS

>CYP110B2   Nostoc punctiforme NZ_AAAY02000005 gene = Npun6097
MKLPKGPQSPAVLQMLRWITSPMSFMETCAKRYGDMFTIRLDSK
SPPLIFVSKPEVLEQILTNDIKGLEAPGDTNLVFESLLGKHSVITISGAEHQRQRQLL
LPPFHGERMRSYSQIISDITEKVISQYQIGQPFNIRSVTQAITLRVIMQAVFGLDEGP
RAEKLQHCLAEMLEKGSSVLSAALLYFPALQRDFGPINFWGKQMRRQQAADKLIYEEI
RERQEQPDPSRTDILSLLMAARDEAGQPMTDEKLRDELMTLLVAGHETTATALAWAFY
WIQKIPTVRQKLLKELDSLGDNPDPSTIFKLPYLNAVCSETLRIYPVAMLTFARVVRT
PLSLGGYELEPGIGVIGSIYLTHHREDLYPEPKQFKPERFLERQFSPYEYLPFGGGAR
RCIGLAFAQLEMKLALAKILSTRELELVDNSEVRPKRRGLVTGQDRPIQMVVTSQRQV
KFPILQTATV

>CYP110C1   Nostoc sp. PCC 7120 Same as Anabaena GenPept BAB76385                 
1 MKYQIQRPNP LKTHPFLQKL QWIADPVEYM KKASLQHPDM FTAEVIGFGD TVVFVSHPQG
 61 IQTLFANDRK KLVAVGEANR ILYPLVGNNS MFLLEGVKHK QRRQLLMPSF HGERMREYGH
121 LIRNITENLF SQLQQDVTFS ALTAMREISM QVILQAVFGF YEGERCQQFK HLLPIFLSEL
181 FQSPLASSIL FFPSLQKDLG NLTPWGRFVR QREKIDKLLY AEIAERRQEI NSDRIDILSL
241 LISARDETGD SMSDKELRDE LITLMISGHE TTGTAMAWSL YWILQTPEVF QRLIQELDSL
301 GDSPDPMSIF RLPYLTAVCN ETLRINPVAM LTLPRVVKEP IELLGNRLET STTVVGCIYL
361 THHREDLYPE SKLFKPERFL KREFSQYEFM PFGGGVRGCI GQALAMFEMK IVLATVLSRY
421 QLALADRKPE RPQRQGFTLT PTNGVKMLIT GQHKRQNYSM AASTTFNA

>CYP110C2   Nostoc punctiforme GenPept ZP_00108280.1
1 MQLPNILKSP SLLQKLHWVS DPIGYMENAA QEYPDIFTGK IVGFGDTVVF VNHPQAIQEI
 61 LTNDRKKFTA VGELNGILKP LLGDNSVLML ESDRHKRQRQ LVTPSFHGER MQAYGQLICN
121 VSKKIFNQLP LNKPFVARNL TKEISLQVIL QSIFGFYEGE KIQKLRQLLP LLLELFESPL
181 SSSLFLFSFL QQDLGAWSPW GNFLRVREKI DQFLYTEIAE CQQQADPERI DILSLLISCR
241 DEAGQPMTDQ ELRDQLITLI LAGYDTTATA MAWGLYWIHK QPLVCEKLLQ ELDTLGDSPD
301 PMSISRLPYL TAVCNETLRI HPVTMFSFPR VVQEPLELLG HSLEPGTILL PSIYLTHHRE
361 NLYPQSKQFK PERFIERQFS PYEFLPFGGG VRRCMGEALA LFEIKLALAT IVSHYHLALV
421 DQRPEQPQRR GFNLAPGSGV KMVMTDQRAR KESLINMTTT PLS

>CYP110D1   Nostoc sp. PCC 7120 Same as Anabaena GenPept BAB76465                 
1 MTVTQNLPNG PRIPRLLRLF KFITQPIQYV EDFAKVYGDN FTIWGSGESY FVYFSHPQAL
 61 EQIFTNVSCF ESSGGGSPLL ELLLGKNSLI LLEGDRHQRQ RQLLTPPFHG ERMRAYGQTI
121 REITQQVTQA WQMGKPFNIR ASMQEITMRV ILRVVFGVDE GELFQELRQL LTTLLDFMGS
181 PLMSSTFFFS FTQKDYGAWS PWGRMVRLIK KIDQLIYALI AQRRAEFGEN RQDILSLLIS
241 ARYDDGQPMS DVELRDELMT MLVAGHETTA SALTWAFYWI DSVPEVREKL FQELDTLNDD
301 SEPSIIAKLP YLTAVCQETL RFYPIVLNAF FRRTKNPMEI MGYKLPKATL VVPSIYLAHH
361 REEVYPQSKQ FRPERFLEKQ FSPYEYLPFG GGNRRCIGLA FAQYEMKIVL ATILSQFQVS
421 RLSKRPVQPV RRGLTLAAPG GMKMVANKRM RNS

>CYP110D2   Nostoc punctiforme NZ_AAAY02000028 gene = Npun3650
MNIPLSVTLSNMKSRNNKIQKPSNLQTPMTATYNLPDGPQMPRW
LRTIKFISQPVKYVDDFAKTYGDTFTIRSSRSDNHIVYFSQPQALEEIFTADSRHFEV
GRGNTGLRFLLGDRSFMLVDGDRHQRQRQLLAPPFHGERMRAYGEDIRKITQQVSHEW
KIGKPFNIRESMQEITLRVILRVVFGLNEGELFEELRRSLSDLLDFISSPIMSSAFFF
RFIQKDFGAWSPWGRILLQRQKVDLLIYTLLRERRAQTDQNRQDILSLMMAARYDDGQ
GMSDEELHDELMTLLVAGHETTASALTWAFYWIDHLPEVREKLLQELNTIGVNPDLSS
VAKLPYLTAVCQETLRIYPIAMTAFVRIVKTPITIMGYELREGTAIVPSIYLAHHREE
VYPQSKQFKPERFLERQYSPYEYLPFGGGNRRCIGMAFAQYEMKIVLATVLSEFQVSL
VNKRPVHPVRRGLTVATPAGMRMVATPQVKRANTPALV

>CYP110D3   Trichodesmium erythraeum NZ_AABK02000068 gene = Tery3870
MTLPDGPSLSPLQRRLRTWKFIFSPLSAIEERYSEYGDIFRTNT
NSLYPFIYFCNPKAIQQIFTADPDTFTSGSINGILKYFVGLNSLLLQDGDRHKRQRKL
LMPPFHGDRMRKYGDLIYNITSNVISQWKIEQPFPIRKSTQEISLKVILAAVFGLDQE
GKSYEKLRVLMSDLLDSMSSPLSSTFLFFNFLRKDWGPWSPWGRFLRKKQELHELIIA
EIQTAKKEGNHRDDILSLLLEARDEAGNAMSDEEIKDELLTMLFAGHETTASALAWAL
YWIDMIPSVGEKLMAELATIPSNSDQVAITKLPYLSAICQETLRIYPIAMNAFPRVVQ
KPIEIMGYQLEPGMVAIVPIYLTHHREDIYPEPKKFKPERFLERQFSPYEYLPFGGGS
RRCIGSAFALFEMKLVLATILSQWELKLLPNQRISPVRRGLTMAPPANMRMVVKPKKS
WQKVSQPILTSG

>CYP110E1    Nostoc sp. PCC 7120 Same as Anabaena GenPept BAB76532                 
1 MKLPDSPKIP KFMQLVQWIY QPLQLMEASA KAHGDSFTLW LTNKRPIVFL SNPQAIQELF
 61 TTPLEQLDAR GTAQVLQPLL GENSLLLLSG ETHQRQRKLL TPPFHGDRMR AYGDIITNIT
121 KEVISNWQLG KPFSVRDSMQ EITLRVILQA VFGLREGERY TQLQKRLCDI LDLSGSALRS
181 TLSFLPALQI DLGRWSPWGH FLRQREAIDQ LLYAEIQDRR DHPDPSRTDI LSLMMAARDE
241 NGEAMTDVEL RDELMTLLVA GHETTASALT WALYWIHKLP QVREKLLAEL DNFGDNGDVN
301 EITRLPYLTA VCQETLRIYP IAMVTIPRIT KTNLEIGGHQ FAPGTMLVGC IYLMHRRPDL
361 YPQPQEFKPE RFLEKQYSLY EYLPFGGSNR RCVGMAFALY EMKLILATVL ANVDLALVDN
421 YPVKPTRRGV TLAPSGGKWL IATAQHQKIK NPVEV

>CYP110E2   Nostoc punctiforme NZ_AAAY02000088 gene = Npun1723
MSLLKLPNGPQTHPWIQMYQWLTNPLEYMEACTKRYGDIFTLKL
GQNFAHQVFISNPQAIQQIFTTDPKQLDSGESAGIKAPLLGQQSLLALDGKPHQRQRK
LLTPPFHGERMLAYGELIREITEQVSSQWQVGETFAVLPSMQAISFQVILKAVFGLED
GPRYKKLNELLIKILNPKIPLLRTVLLIFPSMRQDLGAWSPWGKYLRLRQQIDQLIYA
QIQERKAQPNLSGTDILSLMMAARDEAGEPMTDLELRDELMTLLVAGHETTATSLSWA
LYWIHHRPQVREKLLQELDNLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMSALNRLV
KSPLQIGEYNFEPGTILIPSIYLTHHREDLYPESKQFKPERFLERQFSPYEYLPFGGG
NRRCIGMAFALFEMKLVLATVLSRWQMELADSKPVRPVRKGLLFSPAGGVQMVVKGKR
LQNQPILQTSSSSV

>CYP110E3   Trichodesmium erythraeum GenPept ZP_00072591.1
1 MIKLPGPKSP ALTQILQWTA KPIKFMEKCA REYGDTFEVK LNYPIVFISH PKAIEEIFKA
 61 NPKKFDCGSS NKLAQPLLGD YSLLLLDDIP HQRQRKLLMP PFHGKRMQAY GELICNVAQE
121 VASKWEIGQV FSMREFTAEI SLKVILQAVF GLYEGERYSK LEKLLGSLLE SLSSPLKTSM
181 LFFQFLQIDL GPWSPWGNFI KNREEIYELL CAEISERRQK LDPERSDILT MLLLARDEEG
241 EGMSDIELRD ELMTLLIAGH ETTATSLSWA FYWIHHQPEI YQKLSRELET FGDDLNPMTV
301 INLPYMNAVC SETLRIYPVV IIVSPRKTKL PITIMGQT

>CYP110E4   Gloeobacter violaceus PCC 7421 GenEMBL AP006578 
MSLPPGPSSPSPFQLMQWIGCPTDYLHTTAARYGDPFTMRVGVF
PPLVMFSDPRAIQQLFTAEAGTFDAGASNVALRPTLGANSLLLLDGERHQQQRRLLTP
PFHGERMRAYGELIRQVTEEVIVRWQPGKPFLVRNAMQRISLAVILQAVFGLHDGTRL
VRLRQALGSMLDAMSSPLSMAMLLMLPEDFGPWSPRARLQAHLGAIDELLYAEIRERR
EHFDAGAGDILGLLLAARDEAGAAMGDAELRDELMTLLVAGHETTATAMAWALYWIHY
LPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVALIASPRVARHTVRI
LERDYEAGTRLAAGIYLAHHRPETYPEPERFRPERFLERTFSPYEFVPFGGGSRRCIG
MAFALYEMKLVIATVLLERDLRLVQPRLLRPVRRGVTLAPPEGLYLVPTGERSASRLL
SRTSTAGQ

>CYP110E5   Gloeobacter violaceus PCC 7421 GenEMBL AP006578 
MSLPAGPASPPPLQLLQWIGRPTDYLERTARRYGDPFTMRLGLH
SPVTGVFFSSPEAFQQLFNTEPGLFDSGGANASSTFNLLFGTNSLILLDGERHQQQRR
LLTPPFHGERMRSYGELIRTLAEQVTARWNLGTPFQARRSMQRISLGVILKAVFGLHD
GTRYLRVCRLLGNLIDASASPLLFGLRLIFPQDAGPMSPMGQLKAQIDAIDELLYAEI
RERRERPDPRADDILSLLMAARDEAGQGMGDVELRDELMTLLVAGHETTATAMAWALY
WIHRLPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVAMVAFARVPRR
PVRILDREYPAGTFLIPNIYLAHRRPEAYPDPERFRPERFLERTFSPYEFVPFGGGSR
RCIGVAFALYEMKLVLATVLSRVELRLADPRPRLPVRRGLTLAPPEDLHLIPTALRSG
HRDLLPAC

>CYP110F1   Nostoc punctiforme NZ_AAAY02000005 gene = Npun6096
MKILDSLTTPSLLQTLQLIAKPTKTLENYATKYGDIFTMRVMGL
KSPPIVFFSHPQAISDCFAVPAHKLDFKKATHVFKPLFGENSIVFKEARSHQQQRQLL
LPAFHGDNLKSYGQAICQIAEELTQSWTSGTNICIHKLMSKITLEIILQVVFGITHGV
RYQQLKEQLSALLEDVTKPWYSSLFFFPSLQKDLGAWSPWGIFLKRREQIDKLIYAEI
SERRWQNDAMRTDILSLLMSAHDVNGQQMTDEELRDQLVSLLLLGYETTSGVLAWIFY
LIHSHPEVKHRLMQELSTLDNLTNPEAITQLPYLTAVCQETLRIHPIALICTPRMLKE
PVEIMGHKFTSETVLVPCIHLAHRRTDTYPEPEQFRPERFLNQKFSPYEYLPFGGGYR
GCIGAAFSMYELKLVTAIILSRFELSLTDKRPAYPVRRGITIVPSGGVKMVVTKKAKF
KRQTILST

>CYP110G1   Trichodesmium erythraeum GenPept ZP_00074734.1
1 MKQVCALKTP LWLQRFNYIT NPVSYWQKAY SSYKDAFYAQ GINFGKPLMV FYTPSAAKQI
 61 IENCQGDLTT TSFDSELTAI FGDSSFFILE GTNHKKMRKL LIPALHGKHI KTYGELICNL
121 VNNLIENLPF NQSFSALEIA QEISMQVMIK LLFGNYQQER YQKIKQLMIN MVSLFAANVF
181 GFPLFFKFLQ QDLGLVSPWG NFLQQRRKIQ QLIYQEIAER RNHPNQERTD ILSLLMTAQD
241 EKGNFLNDEE LLGQLLSLLF TGNESTAASI AWSWYEVYRN SKIKEKLLEE INNLGDSPEP
301 LSLFNLPYLS AVCNETLRKY PVTMFMIPRI VKNTTEINGY QLDKGMLVTV GTYILHHRED
361 IYDQPEEFKP ERFIEHRFSS FEFLPFGRGM RGCIGADIAL YQMKLTLATI ISHHRLELTN
421 YGQIFPKRRN TILTPIKLRI IKAC

>CYP111A1 P450 lin L23310 Pseudomonas incognita
MERPDLKNPDLYTQQVPHDIFARLRREEPVYWNPESDGSGFWAV
LRHKDIIEVSRQPLLFSSAYENGGHRIFNENEVGLTNAGEAAVGVPFISLDPPVHTQY
RKVIMPALSPARLGDIEQRIRVRAEALIERIPLGEEVDLVPLLSAPLPLLTLAELLGL
DPDCWYELYNWTNAFVGEDDPEFRKSPEDMAKVLGEFMGFCQELFESRRANPGPDIAT
LLANAEINGQPVALRDFIGNLTLTLVGGNETTRNSISHTIVTLSQQPDQWDILRQRPE
LLKTATAEMVRHASPVLHMRRTAMEDTEIGGQAIAKGDKVVLWYASGNRDESVFSDAD
RFDVTRTGVQHVGFGSGQHVCVGSRLAEMQLRVVFEILSTRVKRFELCSKSRRFRSNF
LNGLKNLNVVLVPK

>CYP111A2   Novosphingobium aromaticivorans GenEMBL NZ_AAAV01000134
MLDLKNPDTYQGGVPYAALQDLRAEGPVHWNPESDGAGFWAVLG
HDEIVAVSRQPDLFSSAFENGGHRIFNENQVGLTGAGESAIGIPFISRDPPSHTQYRK
FVMPALSPARLQGIEERIAKRVERLFAQVPLGETVNILPLLTVPLPLLTLAELLGVPA
DLWPDLHRWTDAFVGEDDPDFRQSPEAMQAVLAEFMGFATALFEDRRANPGPDIASLL
ANTEIRGEPAPLRDFIANLILALVGGNETTRNSINHTMIALAENPGQWDILRADPSLM
TAAVKEMVRFASPVIHMRRTAMRDTQLGQQAICKGDKVVIFYPAGNRDPAVFENPDRF
EITRPVRQHLAFGSGAHVCVGSRLAEMQLRLAFAEMARHVRAFEVVGEPSRVRSNFIN
GFKRLEVRLLV

>CYP112A1 BJ-1 U12678 Bradyrhizobium japonicum
MSEQQPLPTLPMWRVDHIEPSPEMLALRANGPIHRVRFPSGHEG
WWVTGYDEAKAVLSDAAFRPAGMPPAAFTPDSVILGSPGWLVSHEGREHARLRAIVAP
AFSDRRVKLLVQQVEAIAAHLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDH
AFFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPDDNLLTDLLAAVD
QGKASEEEAVGLAAGMLVAGHESTVAQIEFGLHAMFRHPQQRERLVGDPSLVDKAVQE
ILRMYPPGAGWDGIMRYPRTDVTIAGEHIPAESKVLVGLPATSFDPHHFDDPEIFDIE
RQEKPHLAFSYGPHACIGVALARLELKVVFGSIFQRLPALRLAVAPEQLKLRKEIITG
GFEQFPVLW

>CYP112A2 AE000083 Rhizobium sp. NGR234
MPEQPLPTLPMWRVDHIEPSPTMLALRANGPIHNVRFPRGHEGW
WVTGYDEAKAVLSDAAFRPAGMPPAAFTPDCVILGSPGWLVSHEGGEHARLRTIVAPA
FSDRRVKLLAQQVEAIAAQLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDHA
FFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPGDNLLTDLLAAVDR
GEATEEEAIGLAAGMLVAGHESTVAQIEFGLLAMLRHPQQRERLVGNPSLVDKAVEEI
LRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPRHFEDPEIFDIGR
DAKPHLAFSYGPHYCIGMALARLELKVVFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEFPVLW

>CYP112A3    Mesorhizobium loti GenPept NP_106888                
1 MSEQPLPTLP MWRVDHIEPS PEMLALRANG PIHHVRFPSG HEGWWVTGYD EAKAALSDAA
 61 FRPAGMPPAA FTPDSVILGS PGWLVSHEGG EHARLRTIVA PAFSNRRVKV LAQQVEAIAA
121 QLFETLAAQP QPADLRRHLS FPLPAMVISA LMGVLYEDHA FFAGLSDEVM THQHESGPRS
181 ASRLAWEELR AYIRGKMWDK RQDPGDNLLT DLLAAVEQGN ATEEEAIGLA AGMLVAGHES
241 TVAQIEFGLL AMFRHPQQRE RLVGDPSLVD KAVEEILRMY PPGAGWDGIM RYPRTDVTIA
301 GVHIPAESKV LVGLPATSFD PRHFDDPEIF DIGRDENPHL TFSHGPHYCI GMALARLELK
361 VVVGSIFQRF PALRLAVAPE ELKLRKEIIT GGFEEFPVLW

>CYP112A4   Rhizobium etli symbiotic plasmid p42d NC_004041 55365..56645
MSEQSLPTLPMWRVDHIEPSPEMLALRAKGPIHRVRLPSGHECW
WVTGYDEAKAVLSDAAFLPAGMPPADFTPDSVILGSPGWLVSHEGDEHARLRTIVAPA
FSNSRVKLLTQQVEAITVQLFDTLAVQPQPADLRRHLSFPLPAKVISALMGVPFEEHA
FFAGLSDEVMTHQHESGPRSASGLAWEELRAYIHGKIRGKRQDPGDNLLTDLLAAVDQ
GKATEEEAIGLAAGVLVAGHESTVAQIEFGLLAMFRHPQQRERLVRDPSLVDKAVEEI
LRMYSPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPCHFKDPEVFDIGR
DANPHLAFSYGQHNCIGAALARLELKAIFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEMPVLWCGRPPASQSSHLAAPGAHRSDQPLDR

>CYP113A1 U82823 eryK Saccharopolyspora erythraea
MTTIDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHAD
VQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTPRTISDLEP
RIRDVTRSLLADAGESFDLVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQM
DDPTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAA
NFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQ
MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQFSFGH
GVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLAGSS
PRQSA

>CYP113B1 U08223 Streptomyces fradiae
MTTQTLEAEKPPEPERTANSVHPLAQPAGAGARGLLEWFARARA
EAPVFWDESRQAWQVFRYDDYLTVSTNPQLFSSDFSPVFPVPEELAILMGPGTFGGID
PPRHGPLRKLVSQAFTPRRIATLEPRIAEITRGLLDGLREKGQIDVVSDLAYPLPVIV
IAELLGIPAEDRDLFREWVDVILNNEGMEYPNLPDDFSETMGPAIKEWGDYLYRRIAL
KRETPTDDLMSGLIEAEVEGRRLTDEEIVNIVALLLTAGHISSATLLGNLFLVLDEHR
EAQAELRADRDLIPGAIEETLRYRSPFNNIFRLLKEDTDILGHPMKAGQMVVAWIASA
NRDSAHFSDPDTFDVRRQPNKHMSFGHGIHHCLGSFLARLEAKVFLELFFDEFSDYRV
EHDEVEFYEEDELTARRLPVTVTRH

>CYP113B2    Streptomyces caelestis GenEMBL AF016585 
MVDSVTGPMELSKDANAKELLDWFSHNRTHHPVFWDEGRQAWQV
FRYDDYLTVSNHPEFFSSDFTEVAPTPPELEMILGPGTIGALDPPAHGPMRKLVSQAF
TPRRMAGQEQRIRVIAEELLDRVRGQKTIA

>CYP113C1   Streptomyces virginiae GenEMBL AB072568 4994..6202
MAQQTPPAPPSMADGGKAMLAWLRTMRDEHPVHEDQYGVFHVYR
HSDVLAVTSDPAVFSSDLSRLRPDSSALSEEILSVIDPPLHRKLRSLVSQAFTLRTVA
DLEPRVTELAGRLLEKVEGSEFDLVGDFAYPLPVIVIAELLGVPAEDRELFRGWSDRM
LSMQVDDPLEIQFGDEAGEDYERLVKEPLKEMHAYLQRHVDARRETPGDDLLSRLVTA
EIAGERLTDRQIVEFGALLLMAGHVSTSMLLGNTVLCLEENPETAAALRADRALISGV
IEEVLRMRPPITVAARVTTGEVVVGGVTIPKDRMVMASLLSANHDERHIQDPEVFDPR
RSPNPQLAFGHGIHYCLGGPLARLEGRVALEMLLDRFEDIRVTPGAPYDFHREGLFVP
ARSPLTVRRG

>CYP114A1 BJ-3 U12678 Bradyrhizobium japonicum
MLSRHADIFWAFKATGDAFRGPAPGELARYFSRAATSPSLNLLA
STLAMKDPPTHTRLRRLISRDFTMGQIDNLRPSIARIVAARLDGITPALERGEAVDLH
REFALALPMLVFAELFGMPQDDMFELAAGIGTILEGLGPHASDPQLAAADAASARVQA
YFGDLIQRKRTDPRRDIVSMLVGAHDDDADTLSDAELISMLWGMLLGGFVTTAASIDH
AVLAMLAYPEQRHWLQADAARVRAFVEEVLRCDAPAMFSSIPRIAQRDIELGGVVIPK
NADVRVLIASGNRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQL
ARVQLAESLPRIQARFPTLAFAGQPTREPSAFLRTFRTLPVRLHAQGS

>CYP114A2 AE000082  Rhizobium sp. NGR234 
MDMQETTTACADAFAELASPACIDDPYPFMRWLREHDPVHRAAS
GLFLLSRHADICWALKATGDAFRGPAPGELARYFPRAATSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTMREIDNLRPSIARFVAARLDGMAPALERGEAVDLHRQFALALPMLV
FAELFGMPQDDMFGLAAGIGAILEGLSPHASDPQLAAADAASARMKAYFGDLIQRKCI
DPRHDIVATLVGAHDDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPDQ
RHWLQGDAAGVEAFVEEVLRCDAPAMFSSIPRIAQSDIELSGVVIPKNADVRVLIAAG
NRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQLARVQLAESLPR
IQARFPTLTVAEQPTREPSAFLRTFRALPVRLHAQGDSPRLTSAFLNGQRGVEGGASF
EHGDGERRSATDRRAQP

>CYP114Av1    Mesorhizobium loti GenPept NP_106889          
1 MDVQETTAAC RDAFAELASP ACIQDPYTFM RWLREHDPVH RAASGLFLLS RHADIYWALK
 61 ATGDVFRGPA PGELARYFPR AETSLSLNLL ASTLAMKEPP THTRLRRLIS RDFTIRQIDN
121 LRPSIARIVA ARLDGMAPAL ERGEAVDLHW EFALAVPILV FAELFGMPQD DMFGLAAGIG
181 AILEGLSPHA SDPQLAEADA ASARVQAYFG DLIQRKRTDP RNDIVSMVVG AHDDDADTLS
241 DAELISMLWG MLLGGFATTA ATIDHAVLAM LAYPEQRHWL QGDAVGVKAF VEEVLRCDAP
301 AMFSSIPRIA QRDIELGGVV IPKNADVRVL IAAGNRDPDA FSDPDRFDPA RFYGTTPGMS
361 TDGKIMLSFG HGIHFCLGAQ LARVQLAESL PRIEARFPTL ALAEQPTREP SAFLRTFRAL
421 PVRLHAQGG

>CYP114A4   Rhizobium etli symbiotic plasmid p42d NC_004041 56651..58252
MDVQDTTAACHDAFAELASPACIQDPYPFMRWLREHDPVHRAAS
GLFLLSRHADIYWAFKATGDAFRGPAPSELARYFPRAASSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTVGQIDNLRPSIARIVAARLDGMAPALERGEAVDLHREFALALPMLV
FAELFGMPQDDVFELSAIVSAILEGLSPHASDPQLAAADVASARVKAYFGDLILRKRA
DPRRDIVSTLVGAHTDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPEE
RHWLQGDAAGVEAFVEEVLRCEAPAMFSSIPRIAQRDIELHGVVIPKDADVRVLIAAG
NRDPDAFADPDRFDPVRFYGTRPGMSSDGKIMLSFGHGIHFCLGAQLARVQLAESLPQ
IQARFPTLALAEQPTREPSAFLRTFRALPVRLHAQAAAEVRVVVDQDLCGTTGQCVLT
LPGTFRQREPDGVAEVCMATVPQALHAAVRLAASQCPVAAIRVIESEAGDDHCTNPGP
TPSPADAERHAAKDLRNPGEHDGTI

>CYP115P pseudogene U12678 1351-1578 Bradyrhizobium japonicum
FDVTRRHNPHLSFGQGPHFCLGAALARLELGCAFPALFVRLEHLALTIAAEDVVYMPSYV
IRCPQRLPVTFRPSIA

>CYP115A1P BAC47408 Bradyrhizobium japonicum USDA 110 52% to 107A1 C-term 88% to NP_106680 same as CYP115P
 1 MADTSGARSN LLHQSVRSIY 
   GDADRFDVTR RHNPHLSFGQ GPHFCLGAAL ARLELGCAFP
61 ALFVRLEHLA LTIAAEDVVY MPSYVIRCPQ RLPVTFRPSI A

>CYP115A2v1 NP_106680 Mesorhizobium loti 39% to 154C1 41% to 154A1 88% to CYP115P
  1 MPAAPTQLDR LSSAILRQGG MARVSLPGDV VTWAAARHQT LRQMLSDQRF NKDWRQWRAL
 61 QDGEIPEDHP LIGICKVDNM TTAHGADHRR LRGLLSSSFA PSRIALLAPR VEQCVDRLLA
121 EMAQRGGSAD LMSEFAAPLP TNVIAELFGL PDEQREEIVA LTYSLASTSA TAEEVRQTRQ
181 RIPEFFRRLI ALKRGQLGDD LASALIVARD KGELVSDTEL IDMLFMVLSA GFVTTAGVIG
241 NGVLALLTHP QQLHLVRSGQ VPWSQAIEEI LRWGTSAANL PFRYATQDVE IDGCLVRRGD
301 AVLMAFHAAN RDEKAFGPGA NRFDVTRRHN PHLSFGEGPH SCLGAALARL ELRCAFPPLF
361 GRLEDLALTI AAEDVVYMPS YVIRCPQRLP VSFRPSVA

>CYP115A3P   Rhizobium etli symbiotic plasmid p42d NC_004041 54883..55296
ANSYGRPTYGDTDMFDFNRLQNPHLPLGQGPHLCLGAALARLELGSVFPPPFVRPEDLALAIAAE

>CYP116A1 U17130 Rhodococcus erythropolis gene="thcB"
MTVDHAPEGVKSPTGCPVSGMAADFDPFRGAYQVDPSSSLRQAR
KDEPVFFSPLLDYWVVTRYEDIKQIFKTPSVFSPSITVDQITPISDEALQILGSYQFA
AGRMLVNEDEPIHTERRRLLMQPFEADNVATLEPKIREVVNTYLDRVIKDGRADLIGD
LLYEVPCIVALIFLGVPDEDIETCRQYGMQQTLFTWGHPTGDEQTRVATGMGKFWEFA
GGLVDKLKADPNAKGWIPHAIEMQRQHPDLFDDNYLQNIMFGGVFAAHETTTNATGNA
FRTLLENRSSWDEICADPTLIPKAIEECLRYSGSVVAWRRKAVVDTTVGEVDIPAGGR
LLIVMASANRDDSMFPEPDDFDIHRGNAQRHLTFGIGSHTCLGATLARLEMKVFLEEV
SRRLPHMSLVAGQEFSYLPNTSFRGPEHVLVEWDPQQNPVPADRP"

>CYP116B1   Ralstonia metallidurans GenEMBL NZ_AAAI01000322 
MPQTNAPASSGSCPIDHSALRAPNGCPISHQAAAFDPFEDGYQQ
DPPEYVRWSRAQEPVFYSPKLGYWVVTRYDDIKAIFRDNITFSPSIALEKITPTGEAA
NAVLASYGYAMNRTLVNEDEPAHMPRRRALMEPFTPAELAHHEPMVRKLTREYVDRFI
DTGRADLVDEMLWEVPLTVALHFLGVPEEDMDLLRQYSIAHTVNTWGRPKPEEQVAVA
HAVGNFWQLAGRILDKMREDPSGPGWMQYGLRKQRELPEVVTDSYLHSMMMAGIVAAH
ETTANASANAIKLLLQHPDVWREICEDPALIPNAVEECLRHNGSVAAWRRLVTRDTEV
GGMSLAAGSKLLIVTSSANHDEHHFADADLFDIHRDNASDQLTFGYGSHQCMGKNLAR
MEMQIFLEELTSRLPHMRLAGQRFTYVPNTSFRGPEHLWVEWDPARNPERTDPTVLAP
RDAVRIGEPTGGTTGRTLIVERVETAAQGVSRIRLVSPDGRALPRWSPGSHIDIECGH
TGISRQYSLCGDPADTSAFEIAVLREPESRGGSAWIHASLRAGDKLKVRGPRNHFRLD
ETCRRAIFIAGGIGVTPVSAMARRAKELGVDYTFHYCGRSRASMAMIDELRALHGDRV
RIHAADEGQRADLAQVLGAPDANTQIYACGPARMIEALEALCATWPEDSLRVEHFSSK
LGTLDPSREQPFAVELKDSGLTLEVPPDQTLLATLRAANIDVQSDCEEGLCGSCEVRV
LAGEIDHRDVVLTRGERDANNRMMACCSRAAKGGKIVLGL

>CYP116B2   Rhodococcus sp. NCIMB 9784 GenEMBL AF459424 
MSASVPASAPACPVDHAALAGGCPVSANAAAFDPFGSAYQTDPA
ESLRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNILFSPAIALEKITPVSAEATAT
LARYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESG
KADLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAV
GRFWQYAGTVLEKMRQDPSGHGWMPYGIRKQREMPDVVTDSYLHSMMMAGIVAAHETT
ANASANAFKLLLENRAVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATADTRIGDV
DIPAGAKLLVVNASANHDERHFERPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEM
QIFLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLHRHQ
PVTIGEPAARAVSRTVTVERLDRIADDVLRLVLRDAGGKTLPTWTPGAHIDLDLGALS
RQYSLCGAPDAPSYEIAVHLDPESRGGSRYIHEQLEVGSPLRMRGPRNHFALDPGAEH
YVFVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSE
EGTRIDLAALLAEPAPGVQIYACGPGRLLAGLEDASRNWPDGALHVEHFTSSLAALDP
DVEHAFDLELRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVAVLDGEVD
HRDTVLTKAERAANRQMMTCCSRACGDRLALRL

>CYP116B3    Rhodococcus ruber AY957485 P450 half
MSASVPASACPVDHAALAGGCPVSTNAAAFDPFGPAYQADPAES
LRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNLVFSPAIALEKITPVSEEATATLA
RYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESGKA
DLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAVGR
FWQYAGTVLEKMRQDPSGHGWMPYGIRMQQQMPDVVTDSYLHSMMMAGIVAAHETTAN
ASANAFKLLLENRPVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATTDTRIGDVDI
PAGAKLLVVNASANHDERHFDRPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEMQI
FLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLQRQHPV

>CYP117A1 BJ-4 U12678 Bradyrhizobium japonicum
MFGGTLVAQDGIAHRQARDAIQAALLPKGLTLAGIGELFAPVIR
ARVQRWRERGDVTILRETGDLMLKLIFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDL
PGLPLRRGRAARDWIDARLREFVRAAREHASRTGLINDMVSAFDRSDDALSDDVLVAN
IRLLLLGGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEA
LFRETLRVHPATPLLVRRALRELRIGQQRIPTGTDLCIPLLHFSTSALLHEAPDQFRL
ARWLQRTEPIRPVDMLQFGTGPHFCMGYHLVWLELVQFCIALALTMHEAGVRPRLLSG
VEKGRRYYPTAHPSMTIRIGFS

>CYP117A2 AE000082 Rhizobium sp. NGR234
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDG
GAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRD
ARAHAARTGLINDMVSAFDRSDDALSDDLLVANIRLLLLAGHDTTASTMAWMVIELAR
QPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPATTLLPRRALQELQL
GQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVC
IGYHLVWLELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS

>CYP117A3    Mesorhizobium loti GenPept NP_106891                 
1 MDMLLNPLDR RHRLRDDIPV VPGAFPLVGH LPAIVCDLPR LLRRAERTLG SHFWLDFGPA
 61 GHLMTCVDPD AFALLRHKDV SSALIEEIAP ELLGGTLVAQ DGGAHRQARD AIKAAFLPKG
121 LTQAGIGNLF APVIQARVQA WRDRGDVTIL RETGDLMLKL IFSLMGIPAQ DLPGWHRKYR
181 QLLQLIVAPP VDLPGLPLRR GRAARDWIDA QLRQFVRDAR AHAARTGLIN DMVSSFDRGD
241 DALSDDVLVA NIRLLLLAGH DTTASTMAWM VIELARQPGL WDALVEEAQR VGAVPTRHAD
301 LAQCPVAEAL FRETLRVHPA TTLLPRRALQ ELQLGQRRIP AGTPLCIPLL HFSTSALLHE
361 APDQFRLARW LQRTEPIRPV DMLQFGTGPH VCIGYHLVWL EMVQFCIALA LTMHKAGVRP
421 RLLSAVEKGR RYFPTAHPSM KIRIGFS

>CYP117A4   Rhizobium etli symbiotic plasmid p42d NC_004041 59081..60424
MDMLLNPLNRWRRLRDDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCLDPDALALLRHKEVSSALIEEMAPDILGGTLVTLDG
SAHRQARDGIKAAFLPRGLTEAGIGELFEPIIRAQVKAWRDRGEVAILPDTRNLMLKL
TFSLMGIPAQDLSEWHRKYRQLLQLMVAPPIDLPGMPLRRGRAARDWIDAQSRQFIRD
ARARAARTGLINDMVSAFDCSDGALSDDVLVANIRLLLLAGHETSASTIAWMVIELAQ
HPELWDALVEEAQRVGAVPTGHEDLAQCPVAEALFRETLRMHPASSLVPRRAMQELQL
GQRRIPSGTHLCIPLLHFSTSPLLHEAPDQFRLGRWLQRTEPIRPVDMLQFGAGPHVC
MGYHLVWLELVQFSIALALTMQEAGVRPRLMSGVEKGRRYYPTAHPSMTVRIGFS

>CYP118 fragments Mycobacterium leprae
RLGSGIVEQRISVLSIIALADPXXXXXXXDETVWENI
XXXXXXRLLMGDELFTXXXXESNWGKAHN 
SQHDDILDIMLYSADPSTGEQLDTDNV
VNQILTLLVSGSQTLANAIAFALHYLLSIHHDIAAQTRREI
RCLRRVVDATLRLWSXXXXXXRQARRDTTLGNGXXFPKGXXXXXXXXXXXX
RADAWGPDANEFNPDRVLPEICRKLPYTYILFGTGLRTCIGRRFALHEMALELTMIVHQYD

>CYP118      Mycobacterium leprae GenPept CAC31116                 
4 TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH 183
184 DIAAQTRREIYQNRSDRGIANVSY
258 FGDVVKLRCLRRVVDATLRLWS
    VPCYLRQARRD 360
361 TTLGNGTSLFHKGQWVIVLLTAPMPG
    WGPDANEFNPDRXXXXXXXXXXXXXXXX 470
520 FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG 
    YCLSISEAFTLKTVGL 677

>CYP119A1 U51337 Sulfolobus solfataricus (an archaebacterium)
MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLT
GYHERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRET
TRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGE
IFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLI
SNSVIDFTRFNLWQRIREENLYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGE
YVRVWIASANRDEEVFHDGEKFIPDRNPNPHLSFGSGIHLCLGAPLARLEARIAIEEF
SKRFRHIEILDTEKVPNEVLNGYKRLVVRLKSNE

>CYP119A2   Sulfolobus tokodaii GenPept BAB66184                 
1 MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL EMLRSGKVFF
 61 DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV TVKLLSELDE EFDVIESFAI
121 PLPILVISKM LGINPDVKKV KDWSDLVALR LGRADEIFSI GRKYLELISF SKKELDSRKG
181 KEIVDLTGKI ANSNLSELEK EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA
241 LKAVEEALRF SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP
301 DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID NEVLNGYRKL
361 VVRVERA

>CYP120A1 D64003 Synechocystis sp.
MITSPTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGKKRQQQFG
PIFKTRLFGKNVIFISGALANRFLFTKEQETFQATWPLSTRILLGPNALATQMGEIHR
SRRKILYQAFLPRTLDSYLPKMDGIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFM
GEKVSQNPQLFPWFETYIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQP
PSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDI
RERVRQEQNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGF
HFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECL
GKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKLHSLM

>CYP120A2   Trichodesmium erythraeum NZ_AABK02000021 gene = Tery2088
MTANYLEKWVEMGTLTWYPEIRNYTFDIASLLFMGSDESSQTKL
VSLFEEWVKGLFSIPLSLPWTRFGKSLRCRQKLLQHIEEIILQRQQQQNLGEDALGIL
LQAQDKEVNGLSLDELKDQILLLLFAGHETLTSAIASFCLLTSQHLDVLTRLRQEQKQ
FSAIEPLTLENLKRMTYLDMVLKEVLRLIPPVGGGFRQVTQDCEFCGYSIPKGWLVQY
QIAKTHQDETLYPDDKNFDPERFAPENAVDKQKVFGYVPFGGGMRECLGKEFARLEMK
IFAVMLLRGYEWELLPEQDLSVVAAPTPYPRDGLKVKFRKVE

>CYP120B1   Nostoc punctiforme NZ_AAAY02000018.1 gene = Npun4299
MKTNQIPPGSFGLPVLGETLSFVFDRDFAKKRYHQYGPIFKTHL
LGRPTVVMAGPEALEFVLSSHIENFSWREGWPDNFKTLLGESLFLQDGEEHRRNRRLM
MPALHGPALASYFSTMEDITRSYLQKWEKKQEFTWFQEFKQLTFDIASQLFLGTRPGP
ECVRLSQLFTTLTNGLLAINPLPLPFTTFGKAIAARNEILEHLTQVVRERQQNPTQDT
ISLLIKAKDEDGNSLSEKEIIAQAVLLLFAGHETTTSMLTWLCTELACHPEVLEKARV
EQLQLASQGDLDLEQLGKMPYLEQVLWEVERLHQPVGGGFRGVIKDFELNGYHVPTGW
QLYYSIGVTHQIEEIYSEPELFDPDRFSPQRQEHKKYPFSLVGFGGGPRICIGIAFAK
MEMKIVAAHLLRSYHWEILPNQSLEVVAVPTNRPKDGLRVRFQPR

>CYP120C1   Nostoc punctiforme NZ_AAAY02000127.1 gene = Npun477
MQQLKSAEEIPGSYGLPILGETLEIFRDSELYLWRRFQQYGSVF
KTSVLGRKRAYLIGPSANRLVLVEQAENMSSRIGWYFLESTFGNNILLQDGEEHRLTR
RLMYPAFHGKAIATYFDTIQNIVQDFLKDWGERGTISLNSSFRQLTLMIATRLFLGSQ
NKSEVEQTSQWFTQLLDSSMAIFKWNVPFTLYGRGQNARGKLVAFLREAIAQRIEQGN
LEESKDVLGLLLAAVDEDGNKLSETQVINEALLLLFAGHETTASLLTWVIFELGNHPE
WRERLRQEQLAVVGNNPLSLSHLKQFPQLTNVLKEAERLYPPVYAYNRGVLKDIEYGG
YRIPAGWFVTISPMLTHRLPELYTEPDRFDPDRFAPPREEDKKHPLALMGFGYGSHSC
LGMEFAQMEMKIVLSTLLRHYDWTVKPDYSAIAPVRQPSKVKDILQAYIEPLLIKHPL
DS

>CYP121 Rv2276 Z77163 Mycobacterium tuberculosis
MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWL
VSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAI
TPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL
FRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHV
SDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRI
NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTS
HLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERL
PVLW

>CYP122A1 U65940 Streptomyces sp.
MSTDTPAGTPQAGRCPFAIQDAHRAILDSATVGSFDLFGIKHWL
VAAAEDVKLVTNDPRFSSAAPSEMLPDRRPGWFSGMDVPEHSRYRQKIAGDFTLRAAR
RQEEFVFEAADACLDEIEAAGPGADLVPGYAKRLPSLVINALYGLTPEEGAVLETRMR
GITGSTDLDSVKTLTDDFFAHALELVRAKRDERGDDLLHRLASAEDGEIPLSDDEATG
VFATLLFAGHDSVQQMVGYCLYALLSHPEQEGALRTRPELIDGAVEEMLRFLPVNQMG
VPRVCVADVDLRGVRISVGDNVIPLYSTANRDPEVFPDPDTFDVSRPTEGNFAFGHGV
HKCPGQHVARLLIKVACLRLLERFPDVRLVGDVPMNEGLGLFSPAELRITWGAA

>CYP122A2 rapJ X86780 Streptomyces hygroscopicus
MSTEAQQESTPTARCPFSIQDGHRTILETGTVGAHELFGVKQWL
VAAAEDVKLVTNDPRFSSAAPSGILGDRRPGWFSGMDSPEHNRYRQKIARDFTLRAAR
KQEEFIVRAADSCLDDIEASGPGTDLVPGYAKRLASLAIHDLYGLNEEGPVLEGQMRA
MEGGTDMESIKRLTDEFGHVLALVRAKRDEAGDRLLHRLAESGEDEILLSDEEATGVF
ATLLFAGHDSMQQMVGYSLYALLSHPEQRAALRENPDLIDGAVEELLRFLPLNQLGVP
RVCVEDVELHGQTISAGDNVIPLYSTANRDPGVFADPDTFDITRKPEHNFAFGYGIHG
CPGQHLARVLIKVATVRLFERFPDVRLAGDVPMNEGLGLFSPAELRVTWGAE

>CYP122A3 AF235504  Streptomyces hygroscopicus var. gene="fkbD"
MSTDTHEGTPPAGRCPFAIQDGHRAILESGTVGSFDLFGVKHWL
VAAAEDVKLVTNDPRFSSAAPSEMLPDRRPGWFSGMDSPEHNRYRQKIAGDFTLRAAR
KREDFVAEAADACLDDIEAAGPGTDLIPGYAKRLPSLVINALYGLTPEEGAVLEARMR
DITGSADLDSVKTLTDDFFGHALRLVRAKRDERGEDLLHRLASADDGEISLSDDEATG
VFATLLFAGHDSVQQMVGYCLYALLSHPEQQAALRARPELVDNAVEEMLRFLPVNQMG
VPRVCVEDVDVRGVRIRAGDNVIPLYSTANRDPEVFPQPDTFDVTRPLEGNFAFGHGI
HKCPGQHIARVLIKVACLRLFERFPDVRLAGDVPMNEGLGLFSPAELRVTWGAA"

>CYP123 Rv0766c Z80226 Mycobacterium tuberculosis
MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNF
WAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVS
KGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDR
ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAE
LDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWV
EETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGR
EIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGF
AHLPISVQAR

>CYP123A2   Mycobacterium smegmatis  MSMEG5826 TIGR 
MSLPTVEPVLDPYDYDFHEDPYPYYKRLRDEAPLYRNDERNFWALSRHED
VLKGFRNSTALSNKHGVSLDPVSRNDEAHRVMSFLALDDPAHLRLRTLVS
KGFTPRRIRELEARVTEIAVQHLEIALQSDSFDFVDDFAGKLPMDVISEL
MGVPEEDRVRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRR
RRNVSDDLTSALVEAEIDGDKLTDDEIMAFLFLMVVAGNETTTKLLANAA
YWGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGT
TVPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLG
AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR

>CYP123A4   Mycobacterium vanbaalenii PYR-1 ZP_01207533.1, EAS23092.1 
MTISEVRLDPYNYDFHEDPYPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDPA SRGPHASKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTEIAVTHLDAMLEQATTGDAVDYVDEF AGKLPMDVISELMGVPDADRVQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTDDL TSALLEAEIDGDRLTDDEIIGFMFLMVIAGNETTTKLLANAAFWGHRNPDQLTSVYQDLARVPLWVEETL RFDTSSQILARTVSGELTLYDTTIPDGDVVLLLPGSAHRDERVFENPDDYVIGREIGSKLMSFGSGAHFC LGAHLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR

>CYP123B2   Mycobacterium vanbaalenii PYR-1 ZP_01203471.1,EAS24463.1 
MVSVQIRYDPFDASILNDPYPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPTPP GSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAI LPAAVIADLLGVPATDRDQFRLWSSQLVQVDVNHGQTTDALAAAAAIYAYFTDFLADRRKNPREDLMSAL ANATVDGIGLTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDS PAQGLSRTLTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSEHQVAFGRGIHFCLGAAL ARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV

>CYP124A1 Rv2266 Z77163 Mycobacterium tuberculosis
MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFA
TLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPE
LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQ
ADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSAD
IGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVA
FDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS

>CYP124A1   Mycobacterium avium subsp. paratuberculosis str k10 AE017234.1
MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRD
GAFATLRREAPISFWPAIEMDGFVAGNGYWALTKHEDVHFASRHPEIFSSVPNITIND
QTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERARRLVSSLVANH
PNGEAELVSELAGPLPLQVICDMMGIPEEDHQRVFHWTNVILGFGDPDLATDFEEFLQ
VSMDIGAYATALAEDRRVNHHDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETT
RNAISHGVLALSRYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRG
TKMKAGDKVALWYNSANRDESTFGNPWLFDVARTPNPHLGFGGGGAHFCLGANLARRE
IRVVFDELRHEIPDIVATEEPARLLSQFIHGIKRLPVAWTPPR

>CYP124A1   Mycobacterium smegmatis MSMEG3551  TIGR 
MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAPISF
HPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIVIGDQTPEL
AEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDSVRDRARRLVAGMV
DRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQIFHWTNVILGFGDP
DLTTDFDEFVTVAMDIGAYATALADQRRSAPADDLTTSLVQAEVDGERLT
SAEVASFFILLVVAGNETTRNAISHGVLALTRYPEQRRLWWSRFDELAPT
AVEEIVRWASPVSYMRRTVTRDTELAGTALPAGSKVTLWYGSANRDETKF
DNPWMFDVQRHPNPHVGFGGGGAHFCLGANLARREITVLFSELHRHLPDI
VATEEPDRLQSAFIHGIKRLPVAWR

>CYP124B1   Streptomyces cinnamonensis GenEMBL AF440781 93981..95273
MGLTVGPDNAKRGIVPITDSKPAATFPDLVDPSFWARPHAERVA
LFEEMRGLPRPAFIRQNMPGVPWTFGYHALVKYADIVEVSRRPQDFSSNGATTIIGLP
PELDEYYGSMINMDNPEHSRLRRIVSRSFGRNMIPEFEAVATRTARRIIDELIARGPG
DFIRPVAAEMPIAVLSDMMGIPAEDHDFLFDRSNTIVGPLDPDYVPDRADSERAVIEA
SRELGDYIAGLRAERLAAPGNDLITKLVQVQADGEQLTRQELVSFFILLVIAGMETTR
NAISHALVLLTEHPEQKQLLLSDFDTHAPNAVEEILRVSTPINWMRRVATRDCDMNGH
RFRRGDRIFLFYWSGNRDESVFPDPYRFDITRGTNAHVTFGAVGPHVCLGAHLARMEI
TVLYRELLAALPQIHAVGQPRRLDSSFIEGIKHLHCAF

>CYP124B2   Streptomyces nanchangensis NS3226 AF521085 complement(100196..101467)
MNRGVVSPTEATPASSAKATRPPDFMDPSFWLRPRDERAEVFEK
LRALPGPEFVPPRLPWGPLASGYYALSKHADICEVSRRPQDFSSEGATAILPPEMDEF
YGSMINMDNPEHSRLRRIVARSFGRGMAPKFDAMSRRVARRIVDELIERGPGDFIRPA
AEMPIAVLSTMMGIPGEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDY
IGRLREDRLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQAL
VLLTEHPDQRQLLLSDFELHAKGAVEEILRVGTPINWMRRTATGDCEMNGHRFRKGDE
IFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFCLGAHLARIEIIAMLREL
LASLPDIRVEGEPVRLASSFIEGFKELSCTF

>CYP124D1    Mycobacterium avium subsp. paratuberculosis str. k10
MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY
RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD
APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE
CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ
YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG
ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER
VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV
LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA

>CYP124D2   Mycobacterium vanbaalenii PYR-1 ZP_01204629.1, EAS25621.1 
MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA

>CYP124D3   Mycobacterium flavescens PYR-GCK ZP_01194022.1, EAS09632.1
MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT
GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG
YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR
HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD
IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF
FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT
ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG
ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA

>CYP125A1 Rv3545c Z82098 Mycobacterium tuberculosis
MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFA
ELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKN
DIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAA
AGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSA
ELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNS
ITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKG
QRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFN
AVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH

>CYP125A2 SAV5841 AP005044 Streptomyces avermitilis
MPCPALPDGFDLTDPDLLHQRVPLPEFAELRRTAPVHWVPQQHG
LAGFQDDGYWAVTRHADVKYVSTHPELFSSYLNTAIIRFHETMQREQIDAQRLFMLNM
DPPEHTRVRQIVQRGFTPRAIRALEDTLRRRARSIVETALADAGPDGSFDFVTQVACE
LPLQAIAELIGIPQDDRAKIFDWSNKMIAYDDPEYAITEEVGAESATELIAYAMNMAA
DRKQCPAKDIVSTLVAAEDVGNLASDEFGFFVLMLAVAGNETTRNAITHGMHAFLTHP
DQWDLYKRERPATAAEEIVRWATPVVSFQRTATQDTELGGKQIRKGDRVGIFYSSANH
DPEVFEHPDVFDITRDPNPHLGFGGGGPHFCLGKSLAVVEIDLIFGAIADVMPGLRLT
GDPRRLRSAWLNGVKGLQVSAG

>CYP125A3   Mycobacterium smegmatis MSMEG5951 TIGR
MPTPNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGD
KGYWLVTKHADVKEVSRRSDVFGSSPDGAIPVWPQDMTREAVDLQRAVLL
NMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAAQGAGDFV
EQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSS
FELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAV
AGNETTRNSITHGMIAFAQNPDQWELYKKERPETAADEIVRWATPVSAFQ
RTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHV
GFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNG
IKHWQVDYTGAGKASVSGAPGTCPVAH

>CYP125A4   Mycobacterium smegmatis MSMEG3526 TIGR 
MSDSALHLPAGFDFTDPDIYAERLPVDELAELRRVAPIWWNAQPIGAGGF
DDGGFWVVTKHKDVKEISLRSDVFSSLEKTALPRYPEGTVQDQIEQGRFV
LLNMDAPHHTHLRKIISRAFTPRAVERLRDDLAERARAIVRAAAEEGSGD
FVEQVACELPLQAIAGLMGVPQEDRRKLFDWSNQMVGNQDPEFVANDGAS
AAVELITYGMQLAAQRAAAPGDDLVTKLVQADVEGHKLSDDEFGFFVVLL
AVAGNETTRNSITQGMMAFTDHRDQWELFKRERPVTTADEIVRWATPVTS
FQRTALADTEVSGVRIKKGQRVVMFYRSANFDEDVFTDPYRFDILRDPNP
HVGFGGTGAHYCIGANLARMTIDLIFNAIADEMPDLTPISEPVRLRSGWL
NGIKHWQVDYRGDAAKHRAAQASSQADR

>CYP125A5P   Mycobacterium smegmatis MSMEG5819 TIGR
MATMNTCPFGNGYDFTDPDVLFRGIPVEEFAVLRKTAPVWWNQQGESIFDDGG
YWVISRHEDIKTISRDGGEVWSTNAKGAVMRLPDGVTAEQLDLTKALLIN
HDAPEHTRLRKLVSRLFTPRSVAALEEKLAVAAHDIVAEAKAEGSGNFVE
DIAMKLPLLAIADLIGVPEADREKIFAWSNAIINTDDPDFDSDPTVANAE
LMGYAYTMAEERRRCPADDIVTRLVQADVSGESLGEVEFAFFVILLAVAG
NETTRNAITHGMNAFFENPDQWELFKRERPITAVDEIVRWATPVHCFQRT
AVVDTEIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGF
GGNGAHYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVK
DLQVSYRG*PARLIYYSRMRTHGWSGSAPATD 

>CYP125A9   Mycobacterium vanbaalenii PYR-1 ZP_01208885.1, EAS21554.1 
MPGPNSCPISPEFDFLDASLNLERLPVEELAELRKSEPVHWVDVPGGTGGFGDRGYWLVTKHADVKEVSK HNEIFGSSPDGAIPVWPQEMTREAIDLQKAVLLNMDAPQHTRLRKIISRGFTPRAVGRLEDELRARAQRI AATAATEGSGDFVEQVSCELPLQAIAELLGVPQEDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELITYA MKMAEERAKNPTEDIVTKLIEADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFSRNPDQWELY KKERPETAADEIVRWATPVSAFQRTALEDTELGGVQIKKGQRVVMSYRSANFDEEVFENPHSFDIMRNPN PHVGFGGTGAHYCIGANLAKMTINLMFNAIADAMPDLKPIGDPERLKSGWLNGIKHWQVDYTGQCPVQH

>CYP125A10   Mycobacterium vanbaalenii PYR-1 ZP_01209149.1, EAS21410.1 
MATPTLPPGFDFTDPDLNLERLPVEELAELRRCAPIWWNEQTSGGAGPFGDGGYWVVTKHRDVKEISKHS EVFSSQQKTALPRYPEGSTTEQVETGSLVLLNMDAPRHTHLRKIISRGFTPRAVERLREDLAQRAHNIAK SAAAAGAGDFVEQVSCELPLQAIAGLLGVPLEDRKKLFDWSNQMVSDDDPEFAHYDNRNAATELIMYAMQ LAALRAEQPGEDIVTKLIEADVDGHKLTDDEFGFFMVLLAVAGNETTRNSITHGMIAFTEHPDQWELFKR ERPATAVDEIVRWATPVTSFQRTALRDYELSGVQIKKGQRVVMSYRSANFDEEVFDDPFTFDIMRDPNPH VGFGGTGAHYCIGANLARMTIDLMFNAIADHLPDLSSAGTPDRLRSGWLNGIKHWQVDYTGPSGCPVAH

>CYP125A11   Mycobacterium vanbaalenii PYR-1 ZP_01207525.1, EAS23084.1 
MTATQSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTAPVWWNEQADSIFDDGGYWVISRHEDVKAISRN STQWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEDRLADAAREIV RSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFHWTNAIMNTDDPEFDADPTMANAELMGYAYS MAEERRRCPADDIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDNPAQWELFKR ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPH LAFGGNGAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR

>CYP125A12P  Mycobacterium leprae GenPept CAC30983 51% to CYP125A1 
   1 PGFDFPDPEIYTEQLSV*EPAEMCQAETI**NEQPIGRSGFYDDDY 138
     XXXXXXXXXXXXXX
 174 HSGTFSNLEKTALACYQEGMNDEQISRGKLVLLNIDASQYTRLHKIISPGFIP*AAEQLR 353
 354 DDLXXXXXXXXXXXXXXX 362 
 410 SGDFVEHVSCELSRQAAIAGLPSG 481
 480 VPQEDCKKLFHWSN 521
 522 QTVGAQDPKFATNDPMVTSVKLIM*AMQIAADRAKPLGQVIVTNLVEADIEGHKLSKDEFGSF 710 
 713 VIMLTAAGKENTRNCIMQSMMQFTNFPD*WELYK 814 
 816 KKAPGTTADKIIRQATLVMS 875
 876 FQRTVLK*YELSSVSIKKGQRVVVIYRSANFDEKVLTIRLPCSIMRNPT 1022
1022 PHAGFNDTNVHYCIGIN 1072
1073 LARMTIDRMFHAIAESMPNL*STGKPK*LRSGWLNGVKHWQVD 1201

>CYP126A1 Rv0778 Z80226 Mycobacterium tuberculosis
MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEH
TPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPR
HTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICI
LLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA
DDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQL
QTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRD
PSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP
AEWTRSNRHTGIRHLVVELRGG

>CYP126A2   Mycobacterium smegmatis MSMEG5812 TIGR
MRADLTDLDNFADGFPHALFEAHRREAPVYWHEPTEHTPDGEGFWSVATY
AETLAVLRDPVTFSSVTGGSRPYGGTLLQDLAIAGQVLNMMDDPRHAQIR
RLVSSGLTPRMIARVEEDLRVRARRLLDAVEPGVPLDFLVEVAAELPMQM
ICILLGVPESERHWLFHAIEPQFDFSGSRTASVGQLTPEEAGNRMYRYGM
ELIAAKRAAPTDDMLSVVANAHDAELSDLELYLFFSLLFSAGAETTRNAV
AGGLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVE
LGGCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFGQGVHY
CLGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA

>CYP126A4   Mycobacterium vanbaalenii PYR-1 ZP_01207518.1, EAS23077.1
MRVAGALAAVDFTDLDNFAAGFPHGLFALHREQAPVYWHEPTENTPDGEGFWSVATHAETLAVFRDPETY SSVTGGERAFGGTLLQDLPIAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLRERARRLLDEVEPG TPVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIEPSFDFGGARKASITRLSVEEAGSRMFEYGQELI AAKRAQPGDDMLSVVVNSGDPQLSDLESYLFFNLLFSAGAETTRNAIAGGLLALIENPDAYRALRADPGL LPTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLG FGQGVHYCLGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR

>CYP126A5P  Mycobacterium leprae GenPept CAC31567 37% to CYP126 C-terminal
184 DRSLIPSAIEEGSRSETPNWASVTRITIA*LAIGGKTILPNAGVDILMGSANRDGSRWTE 363
364 PNTFDIHWPRQAHTTLAGSHMCLGIGLAQLDTRVMLNNLFD 486

>CYP127A1 AE000101 Rhizobium sp. NGR234 same seq as Z68203
MSDLRRKRVKTNPIPDHVPPALVRHFSLFTSPGMAPTPNGDPHA
AVACVHDDGPPIFYSPSNTRDGRGTWVITRARDQRRVLEDTETFSSHRSIFASALGEH
WPVIPLELDPPAHGVFRALLNPLFSSRRVLALEPTIHARAGALIDCIAKEKTSCDVMK
DFALPFTFSVFLSFLGLSQRRSEVLVGWVSDLLHGNAEKRRAAARSVVAFIDEMAAMR
RKSPAVDFMTFVVQAKIEGRSLTEEEVRGIGVLFLVAGLDTVAAAIGFDMAYLARNPK
HQELLRNEPARLGLAAEELLRAYSTVQIIRVATKDIEFEGVPIREGDYVSCPAMIANR
DPSEFKCPNTIDLARQDNQHTAFGYGPHLCHGAHLARREIVIGLREWLARIPAFRIKE
GTAPITHGGHVFGISNIILTWA

>CYP127A2 U26451 Rhizobium sp.
MILRRNHVALKPVPDHVPPEMVRDFSLFTSPGMQRMPNGDPHAA
VARVHGGPPIFYSPDNTRDSRGTWVITRAKDQRRVLQDSESFSSHRSIFASALGENWP
MIPLELDPPAHGVFRSLLNPLFSPKRVMALEPAIRQRAMALIDRICASRTSCDVMSDF
AFPFAVNIFLRFLGLSDERLDTYVGWGKDLLHGDSVKRTAAALAIVAFIDELAAMRRK
EPTDDVMTFVVETEVDGRRLTDEEVRGIGVLVFVAGLDTVATAIGFDLAHLARNPNDQ
ALLRGEPDRIVPAVEELLRAYSTVQIIRVARKNIDFEGAPIRKGDYISCATMIANRDP
AEFECPNTIDLAREDNRHTAFAYGPHRCLGSHLARREIVIGLEEWLSRIPDFRIKEGT
APITFGGHVFGIENLILDWS

>CYP127A3v1   Mesorhizobium loti GenPept NP_106463                
1 MAINPVPDHV PPEMVRDFSL FTSPGMPPTP NGDPHAAVAC AHDGPPIFYS PYNTQDGRGT
 61 WVITRAADQR KVLQDTETFS SHRSIFSSIL GETWPTIPLE LDPPAHGAFR SLLSPLLSPK
121 RVTALEPAVR ERAIALIDRI TASATSCDVM KDFAFPFTVS IFLRFLGLPD QGLDTFVGWA
181 KDLLHGDDVE RPVAARKIVA FIDELATNRR KDPVDDLMTF IVQAQIEGRR LTDGEIRGIG
241 VLVFVAGLDT VAAAIGFDLA YLARNLKDQE LLRSEPARIL LATEELLRAY PPIQLIRVAT
301 KDIDFEGAPI RKGDYVSCAT MIANRDPEEF ESPNTVDLAR DHNRHAAFGY GPHRCLGSHL
361 ARREIVIGLE EWLARIPTFR IKEGTAPITC GGHVFGIENL ILDWS

>CYP127A4   Rhizobium etli symbiotic plasmid p42d NC_004041 97484..98974
MHLCSERIYRKRGTRENPMSTGRAGEASKKFRLRPTKQRGFRAA
RRSDRCIACHWRLALLRLEIWRSTILLAPSPRRIRSRRRGFDDRRKAVATIRVPEHVP
PEMVKDFSLFTSPGMERMPNGDPHAAVACLHNGPRIFYSPCNTRDGRGTWVIVRAQDQ
RKLLQDTGTFSSHRSLFASALGENWPLIPLELDPPAHSVFRSLLNPLLSPRRIMELEP
AVRDRAIALISKISASSTSCDILTDFAFPFAVSIFLRLLGLSDERLNTFVGWGKDLLH
GDGIRRTAAARTILAFIDELAAMRRKEPADDFMTFVVQAKVDGRLLRDQEIHGIGVLL
FVAGLDTVATAIGFDLAYLARNPTEQELLRSKPDRIVLAAEELLRAYSTVQMIRVATK
DINFEGAPIRKGDYISCATMIANRDPVEFENPNTIDLAREDNRHTAFAYGPHRCLGSH
LARREIIIGLEEWLSRIPDFRIKDGTAPITYGGHVFGMENLILDWS

>CYP128 Rv2268c Z77163 Mycobacterium tuberculosis
MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTR
RRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDF
DPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVT
FSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPAD
VVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGF
RRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMI
STLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPA
GSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILR
EIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP

>CYP129A1 U50973 doxA Streptomyces sp.
MSGEAPRVAVDPFSCPMMTMQRKPEVHDAFREAGPVVEVNAPAG
GPAWVITDDALAREVLADPRFVKDPDLAPTAWRGVDDGLDIPVPELRPFTLIAVDGED
HRRLRRIHAPAFNPRRLAERTDRIAAIADRLLTELADSSDRSGEPAELIGGFAYHFPL
LVICELLGVPVTDPAMAREAVGVLKALGLGGPQSAGGDGTDPAGDVPDTSALESLLLE
AVHAARRKDTRTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAE
VLAGRLAADADGDAISRFVEEALRHHPPVPYTLWRFAATEVVIRGVRLPRGAPVLVDI
EGTNTDGRHHDAPHAFHPDRPSRRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPQ
ARLAVPYEELRWCRKGAQTARLTDLPVWLR

>CYP129A2 U77891 Streptomyces peucetius daunorubicin "doxA"
MAVDPFACPMMTMQRKPEVHDAFREAGPVVEVNAPAGGPAWVIT
DDALAREVLADPRFVKDPDLAPAAWRGVDDGLDIPVPELRPFTLIAVDGEAHRRLRRI
HAPAFNPRRLAERTDRIAAIAGRLLTELADASGRSGKPAELIGGFAYHFPLLVICELL
GVPVTDPAMAREAVSVLKALGLGGPQSGGGDGTDPAGGVPDTSALESLLLEAVHSARR
NDTPTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAEVLAGRLA
ADADEDAVSRFVEEALRYHPPVPYTLWRFAATEVTIGGVRLPRGAPVLVDIEGTNTDG
RHHDAPHAFHPDRPSWRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPEARLAVPY
DELRWCRKGAQTARLTELPVWLR

>CYP130A1 Rv1256c Z77137 Mycobacterium tuberculosis
MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEY
DYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRK
LVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPE
EDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVA
AGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI
PDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAE
LDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSY
VRRPLSVPFRVTS

>CYP130A2   Mycobacterium smegmatis MSMEG5026 TIGR
MSHPAVAFELANADTWADPWDMYTALRDHDPVHHVVPPERPHHDYF
VLSRHADIWAAARDHETYSSAQGLTVNYGELELIGLADNPPFVMQDPPTH
TEFRKLVSRGFTPRQVEAVEPQVREFVVERLERLRAEGGGDIVAELFKPL
PSMVVAHYLGVPEADRAQFDGWTEAIVAANSEAGSALGAGDAVMSMTGYF
AELIERRRREPGDDTISHLVAAGADDEAVDVLSILAFTFTMVTGGNDTTT
GMLGGAVQLLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATR
DVTIGDTTIPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSH
GAHFCLGAAAARMQSRVALTELLTRCPDFTVDLDAVVWAGGSYVRRPLSV
PFRAGA

>CYP130A5   Mycobacterium vanbaalenii PYR-1 ZP_01208620.1, EAS21834.1 
MTAVLSHGSPVHFALADASTWADPWPMYRALRDHDPVHHVVPEDRPNHDYYVLSRHADIWAAARDHQTFS SALGLTVNYGELDLIGLADNPPMVMQDPPVHTEFRKLVARGFTPRQVEAVEPKVHDFVVDRIEHLRANGG GDIVAELFKPLPSMVVAHYLGVPDEDRGKFDGWTDAIVAANTSAGGLGGALDTLGDALGEMMSYFTALIE RRRTEPEDDTISHLVAAGVGADGDISGVLSILAFTFTMVTGGNDTTTGMLGGSVQLLHRRPDQRTMLAEN PDLIPDAVDEFLRLTSPVQMLGRTVTHDVTIGDVTIPEGRRVMFLYGSGNRDERQYGDDAGELDVTRKPR NILTFSHGAHHCLGAAAARMQSRVALTELLTRIPDFEVDESGIAWAGGSYVRRPVSVPFTVTH

>CYP130A6P   Mycobacterium leprae strain TN GenPept AL583920.1
VMSHRFRFTTADIWPNPWSMYRTLRDHEAVHHVVPANQPEDDYYVLPRHADVWSMAMRS
HAKLSSAQRLTVNYSDMELIGLQDNPPMVMQDQPV*TKCRKLVSRRFTPRQTNVVEPKVR
HFVVEHIEQLRAKGSVDIVTELFKPLPPMVVAHYFGFPEKVRSQFDGW
TTAADGGGALFRFPRKSPITIRRLAPAIVAANTADAGGITNELDVAGYAVESMLAYFTR
IATGGNNTVTGMLGG*MPL
SHRRKQHRHWHARRLDAVKDTAEAD
LLRLTSSVRGLMRTTTRDVAIGHTTVSPGRRVLMRYGQAKRDER*YSAAAS*LDVTW*
PPNILIFSHGAH
YLGAKVTRMQRR
VRLTELLARYPDFEVDESSIAWAGGKLHTTP

>CYP131A1 dnrQ L47164 Streptomyces peucetius C-term may be wrong not heme sign.
MPTPTSAPPAAPTDSELGRHLLTVRGFHFVFGALGDPYARRLRG
EADHLSLGELVRDRGPLHGSALGTWVTADGGISARLLDDPLLGPRHPASEGPQEHVLE
NVWETWRTCHVTPLGEDLLTPAAADSDRLAALLGPVLGPRTCTAWQVDAGRAVHRVLD
GLPPHFDVVSDLARPAIAGSLAAVLGLPDEARAELPDLLAACGPVLDSALCPPRLPVA
RAMTQALRRVRELMAAAVANHLTAPADGAVSALLAVDPGGGRDPGDTVTAAVLSTVVG
AETAITTVANAVMALLKHDEQWSLLRADPGRAADAVEETLRWAPPVTLRSLITQGEVQ
IGGETLEADQHVVVLVDAAQRDPALYEDPDRFRLDRPRSPGFTHMALAGRDHLGLVAP
LVRVQCTAVLRALAERLPGLRAEGEPLRRGRSPVVRAPLSLRLAQK

>CYP131A2 L35154 Streptomyces sp. dauQ N-terminal 
MTMPTPTSAPPAAPTNSELGRHLLTVRGFHFVFGALGDPYARRL
RGEADHLSLGELVRDRGPLHRSALGTWVTADGETSAGLLDDPLLGPRHPASEGLQ

>CYP132 Rv1394c Z80108 Mycobacterium tuberculosis
MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGS
DITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWA
RHRGALNSTFARRHLRGLVGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALF
SQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLRE
MQEITLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGH
ETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRY
FSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPT
DRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRP
KHGVHVIGRRR

>CYP133A1 M95628.1 Erwinia herbicola = Pantoea agglomerans whole gene confidential MQLHELMDPDYSDNPFPLYRKLHQQGPLIPAGDKIIISGSHAVVDALLNDRRVGKNYMESVRVRFGDDAAGLPLFQGISRMFLVLNPPDHNRL

>CYP133B1 AE003889  Xylella fastidiosa
MKLTDLSNPAFLENPYPLYETLRAQAPFVSIGPNALMTGRYSLV
DSLLHNRNMGKKYMESMRVRYGDSAADMPLFQAFSRMFITINPPAHTHLRGLVMQAFT
GRESESMRPLAIDTAHQLIDNFEQKPSVDLVAEFAFPFPMQIICKMMDVDIGDAVTLG
IAVSKIAKVFDPSPMSADELVHASTAYEELAQYFTKLIELRRTHPGTDLISMFLRAEE
DGEKLTHDEIVSNVIMLLIAGYETTSNMIGNALIALHRHPEQLALLKSDLSLMPQAVS
ECLRYDGSVQFTMRAAMDDIEVEGELVPRGTVVFLMLGAANRDPAQFTHPDQLDITRK
QGRLQSFGAGIHHCLGYRLALIELECALTTLFERLPHLRLAHLDALNWNQRSNLRGVN
TLIVDLHAKN

>CYP133B1v2  Xylella fastidiosa Temecula1 GenPept AAO29526 6 diffs 
  1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYIES
 61 IRLRYGDTAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG MAVSKIAKVL DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

>CYP133B1v3 Xylella fastidiosa Dixon NZ_AAAL01000071 complement(6849..8057)
MKLTDLSNPAILENPYPLYETLRAQAPFVSIGPNALMTGRYSLV
DSLLHNRNMGKNYMESMRVRYGDSAADMPLFQAFNRMFITINPPAHTHLRGLVMQAFT
GRESESMRPLVIDTAHQLIDNFEQKPSVDLVAEFAFPFPMQIICKMMDVDIGDAVTLG
MAVSKIAKVFDPSPMSADELVHASTAYEELAQYFTKLIELRRTHPGTDLISMFLRAEE
DGEKLTHDEIVSNVIMLLIAGYETTSNMIGNALIALHRHPEQLTLLKSDLSLMPQAVS
ECLRYDGSVQFTMRAAMDDIEVEGELVPRGTVVFLMLGAANRDPAQFTHPDQLDITRK
QGRLQSFGAGIHHCLGYRLALIELECALTALFERLPHLRLAHLDALNWNQRSNLRGVN
TLIVDLHAKN

>CYP133B2v1 AE003887  Xylella fastidiosa
MKLADLSSPAFLENPYPLYETLRRQGSFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLATDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLS
VAVSNIAKVLDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAIL
ECLRYDGSVQFTMRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLDITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHS

>CYP133B2v2  Xylella fastidiosa Ann-1 NZ_AAAM01000051 complement(2764..3966)
MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLATDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLS
VAVSNIAKVFDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLSGYETASNMIGNALIALHRHPKQLARLKSDLSLMPQTVL
ECLRYDGSVQFTVRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP

>CYP133B2v3  Xylella fastidiosa Dixon NZ_AAAL01000066 complement(2275..3477)
MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLAIDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMHVDISDAISLS
VAVSNLAKVLDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAVL
ECLRYDGSVQFTIRAAIDDVSIEGDVVPRGTIVFLMLGAANRDPVQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP

>CYP133B3   Xanthomonas axonopodis pv. citri str. 306 GenPept AAM38014                 
1 MLLSDLATPQ FRHDPYPTYA RLREEGPLVQ VADGRLMSGR YAVVDRLLSD RRVGRDYLQS
 61 VRLRYGEAAV HLPLFQGMSR MFLLLNPPLH TQLRGLMTQA FGARQMESMR EVASDIAAGL
121 IDAFQANGHC DLLTEFAFPL PIAIICRMLD IAAADVTALS HATSALAKVF DPMMTAEELQ
181 ATSVAYDQLA TYFHGVIAQR RSAGGDDLIA RFIQAEDNGR RLSEEEIVSN VILLFFAGHE
241 TTSNMICNAL VALHRHPQQL RLLQETPGLL PNAVLECMRY DSSVQMATRT ALQDFEIEGV
301 AVPRGTMLYL MLGAANHDTL QFTDPQVLDI RRQQGRALSL GGGIHHCLGN RLALIEVEAA
361 LACLLARLPA LRLEQLDTLS WNDRANLRGV DALLASW

>CYP133B4   Xanthomonas campestris pv. Campestris str. ATCC 33913 GenPept AAM42318                
1 MQLSDFATPA FRQDPYPMYA RLRAAGPLVQ ISDNGWVSGH YTVVDALLSD RRVGRNYLDS
 61 IRVRYGANAA EMPLFQGMSR MFLLLNPPVH TQQRALMTKA FGARQLEALR EVAVDTADAL
121 LDQHEDRRSC DLLNDFAMPM TISLICRMLG LAVTDVAALG QASSALAKVF DPLMRPEDMA
181 QATAAYTTLE QYFRAIVLQR RDTQEDDLIA RLIAAEDHGQ RMPVDDIVSN VIMLFTAGHE
241 TTANMICNAL IALHRHPEQL QLLRDTPTLM PNAVLECMRY DSSVQVAMRS VLQPLQVEGT
301 TLPVGAILYL MLGSANHDAE QFTAPQQLDL RRQQGRALSF GGGVHHCLGN RLALIELETA
361 LERLLQRAPA LRLPELDNLS WNERANLRGI QALHATW

>CYP133B5   Ralstonia solanacearum GenEMBL AL646080 77388..78584
MKLADLSTPSFLENPYPLYETLRSQGPFVRIGPNALMTGHYSIV
DALLHNRQMGKSYMESIRLRYGDEGPNMPLFQGFSRMFLMLNPPMHTRLRGLMMQVFN
ARQIESMREVATATAHQLIDDFEQKPSADLVAEFAFPLPVRIICQMMDLDIDDAMALG
VGVSKLAKVFDPAPMSADALVETSAAYEELAQYFTKVIEARRAQPGTDLISMLMRAEE
NGETLTHDEIVSNVILLFIAGHETTSNMIGNALIALHRNPQQLDLLKREPSRMPNAVL
ECLRYDGSVQVTIRAALEDVEVEGEVLPRGTTVFLMLGAANRDPAQFTDPDQLDIGRQ
QGRLQTFGAGIHHCLGYRLALIELESALGALFERLPNLRLTNLDQLSWNQRGNLRGVN
ALMAAW

>CYP134 cypX Z99122 Bacillus subtilis also cypB AF017113
MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS
RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD
HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG
VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL
SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY
KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK
SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT
RGPVSLLVAFDGA

>CYP134A2P  Bacillus cereus ATCC 14579 GenPept AAP10061   
1 MIGATNCDSN VFERPDKFNV YRPDIDIKKA FSGTARHLAF GLSIYNCVGV AFAKLKIEID
61 STIKDNISRK KLRDIKDFVK KTSKMN

>CYP134B1   Photorhabdus luminescens NC_005126 complement(313663..314886) 
MAKLSSFNIHDPKFIKNPYDFYDILHKQDLVYFEQSQNSYFIGK
YEDVDAILKSSIFNTKPLTALAEPVMGDRVLAQMEGEEHACKRKFIMQGLSRDYFNRY
YEPMIRKITEDLLQPYMEKGNIDIVNDFGRDYAVLVTLSILGLPSDNYRDIAEWHKGI
ASFITQFDQTELEKMHSLECSQKLIRLLKPIIDQRRRNPSKDIISIFCQDTAMSMSEI
TALCLNILLAATEPADKILAMMLNHLISNPSMLDVVLKDRSLVRDAFEETLRLTSPVQ
LIPREASEDVTISGIDIPKGAVVFCMIGAANRDPSVFHKPNEFDLYRRKNTTSPQKAN
RKRHLAFGAGTHACAAAAFSLSQLEVSSNIILDLLHNLRFADHYHYQETGVYTRGPSK
LLLSFDPIASSAIKE

>CYP135A1 Rv0327c Z96800 Mycobacterium tuberculosis
MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFS
LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHAR
MRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFG
VTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIA
SRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLW
ELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPA
GTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTE
GAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP

>CYP135B1 AL021942 Mycobacterium tuberculosis H37Rv complete
MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFT
LHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDR
RRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGA
SDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIAD
RRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALER
LTRHPVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAG
YRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGAT
FAMVEMRVVLREILRRVELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATSQA
TAQGAGCPAARGGGPSRAVGSQ

>CYP135B2   Mycobacterium smegmatis
MSTPGTLPPGPPLPAFVQTAMMLRHWSRFVSACRRRYGDVFTLRIASMGT 
WVYLADPADIKTVFAGDPTVFHAGEANSMLSGLLGETSVLVIDEDVHRDR 
RRLMLAPFARDAVARQTGVMAEVAATNIASWPVGTPFPVAPKMAEIALEV 
ILRTVIGATEPARLAALRHVMPQLLGIGPWQSLAIASPGLQRRRPWRTLQ 
RNLAEADRLLYAEIAACRAGPDLASRPDALAMLVRAANDEGRTMTDRELR 
DQLMTLLVAGHETTATGLSWTLERLIRHPAVLDKAVAAARTTDGSGEAYL 
DAVVRESLRIRPVVFEAGRVLTEPVELGGYLLPAGTLVAPSIGLVHASAD 
VYPDPDRFEPDRMLASTQAPSTWLPFGGGNRRCLGATFALVEMRVVLREI 
LHRVDLFATTARGEKQRLKHVTMIPHRGGRICVRALRDVAPAPMTCPAEA 
RRA

>CYP135B5   Mycobacterium vanbaalenii PYR-1 ZP_01204401.1, EAS25393.1 
MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLRCGPRFVAACRRRYGSAFTLRVASMGTLVYLT DPADIKTVFAGDPDIYHAGEANSMLKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAA DNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGPWETLAIANQDLLRRRP WRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVRAGDMSDKELRDQLITLLVAGHDTTATALSW ALERLTRHPAVLAKAVRAARDGDDDYLDAVAKETLRDRPVVFDVGRVLKAPVELAGYRLPAGVMVIPGLV AVHADSQIYPHADRFDPDRMLGATLSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARG 
EHRRLKHVIFVPHRGARIRVRAKRVVAAEAPKCPMSGPA

>CYP136A1 Mycobacterium tuberculosis Z83866 Rv3059 coding region 23158-24636
MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKK
LAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVA
ALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSR
LAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVT
KVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTV
LCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESD
RHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIA
YPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLEIK
TILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR

>CYP136A1   Mycobacterium smegmatis MSMEG0997 MSMEG2291 TIGR
MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP 
AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS 
SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR 
RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD 
IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ 
ARKTLEDYFLSRIDEKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMIF 
LMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEKL 
ETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINHR 
LPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLEI 
KTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR

>CYP136A1   Mycobacterium vanbaalenii PYR-1 ZP_01203885.1, EAS24877.1 
MPSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPPAGSDLKPILGDAGLPIIGHMI EIFRGGPDFILEIYRKHGPVYFAESPALSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLL DFDEHMFHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLDIASEVFMGVPA GTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIKARKTLEDYFSSRIGEKRRSESTDMFSVLCHS ADEDGQSFTDDQIVSHMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEKLE TYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINHRLPELWTDPEKFDPERFAEPRS EHKKHRYAFAPFGGGAHKCIGMVFGQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLR PLH

>CYP136B1   Mycobacterium smegmatis MSMEG1160 TIGR 
MTIPAAEAAADAKVRLQTAVAGITARYPSREHALAAPPPGSGLKPV
MGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVGFRVALLMGPE
ALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRDHRRIMQQAF
TRSALNGYLDLMRPGIDRTVRSWPAAQRFPFYTSVKHLLLDQAAEVFIGA
ELGPEADQLSRDFHDTVCGGQAVIRADVPGGVWSRGLRARRRLERYFAGQ
LPARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNHMIFLLMAAHDTSAIA
ISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDLDSAYPLLDAAFKESL
RMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGVYASMRLADWWPEPDEF
DPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQFANMNVKAIMLHLLRHF
RWHVPAGYQPRMTWGTGPTPADGLPITLERLSA

>CYP136B2   Mycobacterium flavescens PYR-GCK ZP_01192884.1, EAS10792.1 
MSALPQSLPG LPAASAKLRF QSAAASVTSR YPSRVRPLSR PPAGSGLKPV LGNYGFPVLG
HHLSTFVEPL EFARERYERF GPVSWAGGIG FRVVQLMGPE ALETAWINRD KAFSSTRGWA
PVIGPFFHRG IMLLDFEEHR DHRRIMQQAF TRSALDGYLT LMRPGISRTV TSWPTAAGFP
FYTAIKKLLL DQAAEVFVGA VLGAEADRLS SDFHDTVCGG QAMIRADVPG GTWARGLRAR
ERLERYFAAQ IPDRRAGTGA DLFSMMCRSR SEDGDSFSDA DIVNHMIFLL MAAHDTSAIA
ISMLVYELGR NLRWQDALRD EADAGDGLGL ADLDGAYPLL DAAFKEILRM YAPAGTLFRQ
TVTDTEVCGH YIPRRTQVAI NVYASLRLAD WWPDPDRFDP GRFLGGGDAA AVHRYAFAPF
GGGVHKCIGQ QFADMNVKLV MHQLLRQFRW RVAPGYRPLM TWGTGPTPAD GLPISLQRLSGG

>CYP136B3   Mycobacterium sp. KMS ZP_01282080.1 
MTALTAQLTS PANTHRLQVA GAALTSRFPS REEPLATPPP GSNLKPVMGN YGFPFLGHTL
SALAEPLDFA RRRYDMYGPV SWAGGVGFRV VALMGPDALE TAWINRDKVF SSTRGWAPVI
GPFFHRGIML LDFEEHRDHR RIMQQAFART ALDGYLELMR PGIDRTLGGW PASDAFPFYP
SIKHLLLEQA AEVFVGTHLG PESDQLSADF HDTVRGGQAL LRADVPGGVW ARGLRARKRL
ERYFGDQIAD RQRGDGADLF SMLCRSEDDD GARFTPADIV NHMIFLLMAA HDTTAIALSM
LVYELGRNQK WQKTLRDEAV GRPNDAPAVG DLDAYPLLDA AFKEILRMYA PAGTLFRQTT
RDTDILGHFV PAKTQVAINV HASMRLADWW PDPDTFDPAR FIDQPGARAA VSRYAFAPFG
GGAHKCIGQQ FADMTVKTTM HQMLRRFEWS VADGYRIPLT WGTGPTPADD LPITLRTLTT

>CYP136B4   Nocardia farcinica IFM 10152 YP_117347.1, BAD55983.1 
MVEITRSVAK GFGMSLQLPT TVSAVSDNAR HLRTRLSWQA QRAGLQVVKR YPTRIRPLAE
PPPGSGLKPV LGDFGPPGIG YTLHTLADPM GFSRERFERL GPVSWLGVLG RPVVSVAGPE
AFEEVLLDRD KVYSAQRGWE WLIGPFFHGG VMLRDFDDHM FHRRILQQAF TRPRLHGYQD
LTSPLLRRGI ESWRPAAEFH IHTAIKQLLL QQATEVFAGA ELGRESVALA HAFEDAVHGG
TAMVRANVPG GVWARGLRGR RRLEDYFRRE LPAKRAGEGN DLFSVLSRAT TEEGHTFTDE
EVVQHMIFVM LAAHDTSTIA SSMLVYELGR HPEWQDKLRA EAIGLGKESV GYDDLDELPL
LDMAFKEALR MYAPVAQQAR ETIADTALCG HYLPRGTLVM CGPYMMMRTA RYWRDPDEFD
PERFAPERRE DKSHRFAWAP FGGGAHKCIG LYFGGMTVKA VLYQMLTRFR WSVRPGYEPL
LVAGTGPTPA DGLPIRLERL AR

>CYP136D1    Mycobacterium abscessus GenPept AAN38721 
1 MDAVEAAQRP GGTMTNHLLA PAHHVKERLS SVIMVPAPHA VDDRWRRWSR DWPVRELAPA
 61 PAGSGLKAVR GDAGLPFVGH TLDYIRFGSD FSRERYDRLG SVSWMGAFGT KMVVIAGPDA
121 TREAFTSEAK AFSQDGWSFL IDAFFHRGLM LMSFDEHLMH RRIMQEAFTR PRLTGYVEQV
181 TPCVRSAVPA WPVGPSVRIY PLLKELTLDI ATDVFMGGRG KDESDAVNKA FVATVRAASS
241 LVRAPLPGTR FRAGVQGRRV LEDYFFRHLP AARAGETEDL FAALCQATTE DGERFSDEDV
301 VNHMIFLMMA AHDTSTITTT AVTYFLAKYP QWQEAAAAEA AAIGDGLPDI EALEKMTVID
361 RVIKEALRLL APVPLVMRKT VRDVAIDGYH IPSNTLCAIT PAVNHFDRTI WNDPERFDPS
421 RFDEPRREDQ HHRFAWVPFG GGAHKCIGMQ FGTLEVKAIL HRMLRSFTWK VPENYHVRWD
481 NTSLPIPVDG LPLEMKRR

>CYP137 Rv3685c AL022121 Mycobacterium tuberculosis
MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGL
PAPRGFRAAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGDVAIVSDSALAKE
VFTAPTDVLLGGEGVGPAAAIYGSGSMFVQEEPEHLRRRKLLTPPLHGAALDRYVPII
ENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLG
VSEQLTVRYALRRLGALRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLV
SARGESGEQLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGG
GEAFTTAVINETLRVRPPAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYE
HPHEFRPERFLGTRPQTYAWVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAVDD
EPERIVRRSIMLVPRRGTRVRFRPAR

>CYP138A1 Rv0136 Z92770 Mycobacterium tuberculosis
MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVR
RYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGD
DHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILR
AIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVID
KLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLG
WAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGE
WVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAA
FANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR

>CYP138A2    Mycobacterium smegmatis
MTATVERPESAIRAAQLPPVLPLPKTVQGLAFSVARRWVVKQAARRYGDV
VTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPNLSRMLGPGSVFAL
DGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAASWPDGQEFRTLEP
MMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRNYGR
LTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGS
SMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAATD
DNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAH
IQEREEEFSDPHRFDPQRFVGNRPGLGWLPYGGGTRRCVGAVFANIEMDV
VLRTILRHFVIETTTAPDEKVHPRGVAYTPASGGRVVMRRRREPLGA

>CYP138A5   Mycobacterium vanbaalenii PYR-1 ZP_01206398.1, EAS24160.1 
MSEATIAAHRSTADAESAPPRPVRLPPTPRIPKLLQGLGFSFSRQWTVAQIVRRYGDVFSMTLPVFGPTV MVADPALAKQLFMANTDDVGNIQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEET LREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTPHRTYGRFS PWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRSTYEDGSTMSRQDIGDELLTLLAAGHETT AATLGWAFERISRHPEVLAKLVAEAETDGNEYRQATILEIQRSRTVIDFAGRHVYAPTFELGEWVIPQGY SIVVAIGQVHKRAQDFDDPDRFDPQRYIGQRPPTFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVI 
ETTAAPGEKMHSRGVAYTPKDGGRVVMRRR

>CYP138A6P   Mycobacterium leprae GenPept CAC32181 40% to CYP138
  1 NRVAREIVVEVIYGALFGAFEALSGLVPQDTVLGPMGRYSMAPSLIR
439 ITINVIMRAGFGSELDELRRLHPTAATL 522
    RWTVERQARCNHDIFMLDSRSTAERLRRRLHGTCMKNH 351
352 VRIFEAEPLWGLRTGLKASLLPHCRLINRITINVIMRAGFGSELDELRRLHPTAA 516
517 TLVGLF*LLSQHLGVLADPSSMGATMPGDDPAPALRQATIPG
638 LGVQWTRTVIDFAARRVYSSVYHLSEWAIPREDSILISIAQIYXXXXXXXXXXXX 766
795 DPRRYVEHKPSSFAWI 842
    PFSGGT 861
862 SRCVSICQDGDGMNVVLKMVLRYWIIDTTTAPGER*HLRGVVYTPRNGGR 1011

>CYP138C1   Mycobacterium vanbaalenii PYR-1 ZP_01207105.1, EAS23276.1 
MATATTDPVRLPPGPRIPKLIQGAAVLTQRYGAIAALGRRYGPTFTLNIPVFGETVVISDPVLVKDLFST HRDLVGRPQNNLGGDVLGPGSIFNLEGDALQARRKLLLPPFNGKSMRGYASITEEEAIREIRTWPEGVEF ETLEPMMRITLNTILRAVFGAEGEQLDELRELMPKAVEFGSKIALMPSIVRKDFGPWSPGGKFARYRKRM DELLNGLLNDARSDPNFTERNDVLSLLLQARYDDGSPMPDSFILDELLTMLVAGHETTSTQLAWTIERIR RHPQLLVRLTEEVDAGGNELLLATIAESQRTRPVLTAALRRARTRIRLGEWVIPEGDTILASTQLAMAAE SSFPDADKFNPDRFVGNPPNPFAWIPFGGGMMRCIGASFATMEMEVTLRALLREFTIEPTTEPDEKPHSR 
GVTVTPGRNGRLVVHRREHKAARATDSVSVAESS

>CYP138C2   Mycobacterium flavescens PYR-GCK ZP_01193212.1, EAS10582.1 
MATATTDPVR LPPGPRFPKL IQGGAVLAFR YGSVAALGRR YGSTFTLQLP VFGETVVISD
PVLVKDLFST SRELVGRPQN NLGGDVLGPG SIFNLEGDEL LARRKLLLPP FNGKNMRAYE
DITEQEVIRE MQSWPEGVEF ETLEPMMRIT LNTILRAVFG AKGDELDELR VVIPAAVEFG
SKIALLPSVV RKDLGAWSPG GKFARYRRRM DEICTQLIAD ARSDPDFTDR GDVLSLLLQA
RYDNGDPIPD AFVVDELLTM LVAGHETTST QLAWTIERIR RHPDLLARLS DEVDAGGNEL
MAATIAESQR TRPVLTAALR RARTRIRLGE WVIPEGDTIM ASTQLAMAAE QSFPDAEKFN
PDRFVGNPPN PFAWIPFGGG MMRCIGASFA TMEMDVTLRT MLREFRLEPT DEPDEKPHSR
GVTVTPGRGG RAVVRRRRTP ASGDANSVSV AETSR

>CYP139A1 Rv1666c Z95617 Mycobacterium tuberculosis
mrtyrtvRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFAN
ADAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNID
TVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQ
VMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTT
LSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAAD
DLSALTYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPE
IWPEPTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR
AMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ"

>CYP139A2P   Mycobacterium leprae GenPept CAC31622 GenEMBL AL583921.1
GAAVATTSMTVILARLASRTRLHLLAHYTHRVRARNFAALIP*LSLTVEVINSMPTQ

>CYP140A1 Z97193 Mycobacterium tuberculosis cosmid Y180 Rv1880c
MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPF
YDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQ
LHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIV
DVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRG
FDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV
NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR
IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGE
VGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP

>CYP140A2    Mycobacterium smegmatis MSMEG0673 TIGR 
MRERLRWMALHGFVRSMATLGLRRGDPQARLIADPVVRADPTTFADQMRKQGPVIRG
RVVLLTFDHAVAFDLLRSDDFQVSQLGANLPKPLRWIADKTNPGLLHPIE
PPSLLSIEPPDHTRMRKLVSSVFTTRAVATLRERVEQTAHELLDGLEAES
GVVDIVERYCAQLPVAVIGDILGVPEPDRPNILRYGELGAPSLDIGLSWS
QYQQVNEGIIGFETWLNRHLRTLRRDPGDDLLSQIITASESGATGEPLTD
RELKALAGLVLAAGFETTVNLLGNGIRMLLDHREHLETLAARPDVWPNAV
EEILRLDSPVQMTARAAVRDVDVAGTAVGRGELVVLHIAGANRDPKVFDD
PHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRAFFDRFPDARL
AGDPVRRDTRVLRGWSTLPIALGKARAAVGS

>CYP140A3P  Mycobacterium leprae TN GenEMBL L01095.1 48% to 140A1
 234 VRQRLHWFAQYGFIRGIAATHH
 301 RRSDPLARLDIALAIKANPVP
     YCHKPRPRRPLVQSRISYLTANRAITHELLQSEDFHVFWLNVTLPAPSHWL 517
     RRRTGYRTSSQYNL 542
 543 LHPLLAIQ*AYHIHYRKTVSPLFAPKAVATLRDRIEQTTLALLDQLAHQHDVVDVVNRY 719
 720 CSQLPVAVISDILGYP 767
 761 VPDRDRSHILKFGELVAPSLDVELT*Q*YQQA*REVAGFNFWL
     LKHLPQLQRTPGDNLVRHLSH*EDNKPTEISLSKSKLQAISG 1014
     GLVLATGGETTVNLLGRGI 1069
1080 LLLDTPEHMVMLQACPEPGHKRG*EILRLDSPIQMAARVARKDVDLAGSTIKRSQVVVLY 1259
1260 FGRSQPGPVRLCRSR*VQHRTPQCGKESRIFR*QEFCLENALTRAYNAVGLRAFFDHLP* 1439
1440 TRAAGTRSRLDTRVLRGWSTLPIALGPTRSMVS 1538

>CYP140A4 Mycobacterium avium paratuberculosis AJ250018 
GAAARQSRPVGPRRSRRSCDRQPGPDDRAHAPPATSTSAPAMVG
LVPRRARNRDPKVFSDPTTFDVTRPNAREHLAFASGIHACLGAALARIEGATCARSFE
NFPDRSSRARNGGR

>CYP140A6   Mycobacterium vanbaalenii PYR-1 ZP_01208430.1, EAS21996.1 
MAADLQQRIRWLALHGVIRGLSKVAVRRGQDPQARLIADPAVRADPAAFADELRGRGPVIRCRAVLMTVD HQVVNEILRSDDFRVSSLGAGLPKPLQWINRKTHPGLLHPIEPPSLLSIEPPDHTRCRKLVSSVFTTRAV AALRERVQQTANDLLDDLERESGVVDIVERYCSQLPVAVISDILGVPERDRRHILHFGELGAPSLDIGLS WRQYTQVHEGLVGFNEWLGGHMDELRRNPGDDLMSQLIQASQAADEGSRLTDRELQATAGLVLAAGFETT VNLLGNGIRMLLETPGHLETLAARPELWPNAVEEILRLDSPVQMSARFARRDVTVGGTEIKRGELVILHL AGANRDPEVFTDPHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRTFFERYPDARLAGQGSRRD TRVLRGWSTLPITLGTARAALGS

>CYP140B1    Mycobacterium vanbaalenii PYR-1 ZP_01206566.1, EAS24328.1 
MGQHAGRQAGPGGAGRPVGRSGARRSGGGQPWAARAAGRRRAQVGAGAGPGSGRAAHGRHLRRPSPRQPD RRMRSRPAVWLRWATVHGVPRAFLTVRARRGEPLARLILGRGDRLALIEEIRAAGPLMRTPVVWATADYD VCRTVLRDNDFGVADPSETGLPDALLGLIRRVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFTPRSIA ALDTRIGELTAELLDDLGRRREVDLIADYAAQLPAAVISRMLGVPDEDRARILGWGETGAALLDIGIGWR PFRAAIDGLVDVDTHLGAHFRRLHQNGADGTPFSSLALDGSLSGRELISNAALLVGAGVETTVNLIGNGI AALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTARTAHRDTEIAGVGIRKGAVIVMLLGGANRDPK VFDRPQTFDITRANARDHLAFASGIHVCLGAALARIEGATALRELFTRYPDLHLTAPAEPRDLVTLHGYR HLPVRLGRAATATRRAS

>CYP141A1 Mycobacterium tuberculosis Z95150 Rv3121 
MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAW
LVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQG
LNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH
ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQS
TMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIV
RFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPN
EHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIK
ELLVTWPT

>CYP142A1 AL022022 Mycobacterium tuberculosis Rv3518c
MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAAS
TYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
EASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLV
TFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDD
ELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAP
VKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFG
FGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFT
PSPPLG

>CYP142A2    Mycobacterium smegmatis MSMEG5877 TIGR
MTQMLTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQ
AVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRK
RVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPT
ERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEP
TDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLL
RHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRA
GEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLAR
LELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA

>CYP142A4   Mycobacterium vanbaalenii PYR-1 ZP_01207590.1, EAS23149.1 
MTSTLPALDVDLADGNFYADGRAAREAYKWMRANQPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIR PDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDKVPSIENLCDTLIDAVCERGECDFVRDIAAPLPMA VIGDMLGVLPDERDMLLKWSDDLVCGLSSTVDEQTIQKLMDTFAAYTAFTTEVIADRRANPRDDLFSVLV NAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHQDQWRQAVADPELLPGAIEEMLRWTSP VKNMCRTLTADTEFHGTSLKAGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA RLELRLMLTKILQRLPDLRLADESMLPLRPANFVSGLESMPVVFTPTAPVGA

>CYP142B1    Mycobacterium vanbaalenii PYR-1 ZP_01204842.1, EAS25834.1 
MTTAVPTHRDIDLSDRNFWARPHEERDAAFAVLRRENPVPWSRPADSDLLPPEQNLKGFWSLTKHEDIRY ASRHPEIFSSAEGITVEDFPVEIRMMSQSFIAMDAPRHTQLRGITLDAFKPRNMLRLQDWIQGHARDLIS EISHLGEGDFVDLVSVKLPGRIFGSFFGLPPGELHEKTINAAQRTLGWTDPEVRGDLTAVELFVGAVMDL HETVTTLLPERRANPGDDLLSWMVQAEFDGEKMTDDELKAFFTLLAVAANDTTRHASAHAILAFSQFPDQ RDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQDVTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKF DIARNPNPHIAFGGGGPHFCLGAALARTMLRSLLTEVYTRIPDISAPEPRYQVANFINGINSLPATWTPERR

>CYP142B2    Mycobacterium sp. JLS ZP_01275530.1 
MTTVFPETTH GDIDLSAREF WAKPPVERDA AFAVLRRENP VAWSRPADSD LLPPEQNLKG
FWSLTKHEDI RYASRHPEIF SSAQGITMED FPHEILMMSQ SFIAMDAPRH TQLRGITLDA
FKPRNMRRLQ GWVQEHARDL ISEMSHLGEG DFVELVSVKL PGRIFGSFFG LPPGEIHEKT
IDAAQRTLGW TDPDVRGDRT ALELFAGAVM DLHETVTTLL PERRANPGDD LLSWMVQAEF
DGVKMTDDEL KAFFTLLAVA ANDTTRHASA QAIYAFSQFP DQRDLLVADV EGRVDSAVEE
ALRWASPLIH MRRTATQDVT VRGAEIKAGD KVVLWYSSAN RDEDVFDDPF TFDIERNPNP
HLAFGGGGPH FCLGAALART MLRSLLTEVY TRIPDIHAPE PKFQVANFIN GINSLPATWT
PERR

>CYP143A1 AL022021 Mycobacterium tuberculosis Rv1785c
MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFM
NGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYF
SPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRL
IGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLS
EIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLE
PSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWG
FGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS

>CYP143A2P   Mycobacterium leprae GenPept CAC30494 55% to CYP143A1 
   1 MSTSAKANPTHFTYCSLNYSALSMITDRGVIWKTLXX 105
 113 AKPVVFMNG*YYLNVSRKCILHTTSITKGFSSREAXXX 217
 225 PGNALPVLPXXXXXXXXXXXXXXXXXXX 251 
 278 SLNNLNKALPALRTYTVTMANAITSRGEW 364 
 366 EAMTDFANX 389
 391 LFPLQLFLVL*GLXX 429
 434 AQDRDHLIALLKDVVIGMSDKPFLSQADIADQGELCEYLVDTIAERKQNPA 586
 585 PDVLSQVLIGEDPLSEIKVLDLESL 659
 659 MLILAELDTVTATVGFSLLQPACRQQLRTMLRDKPKQIRILIED 790
 792 ILQLEPPAQITPYITTEFVNVDGMTLSPGSRVRLC 896
     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
 993 GSHLARLKLTLAVDEWLINI 1052 
     XXXXXXXXXXXXXXXXXX
1116 LFALKALALHW 1148

>CYP143A5   Mycobacterium vanbaalenii PYR-1 ZP_01203645.1, EAS24637.1 
MSALPHVLYGDLPMAADRGAGWATLREFGPVAYGDGWYYLTRRDDVLAALRNPEVFSSRIAYDDMISPVP LVPLGFDPPEHTRYRRILHPFFSPQALGVLLPSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLTLF GLPLQDRERLIAWKDAIIAFSLTNDPTSVDLTPAVELYGYLTEAVARQREKPREGILSHLLHGDEQLTDN EAVGLSLVFVLAGLDTVTSTIGATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREV TVAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLDGKLHKHWGFGGGPHRCLGSHLARMELRLVVTEWL SRIPDFELAPGYVPEITWPSATCTLPTLPLILTRKTP

>CYP144A1 Z97345 Mycobacterium tuberculosis cosmid Y25C11 Rv1777
MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAE
SVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAE
GTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV
DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLV
AAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGG
ESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTL
DGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALAR
LEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ

>CYP144A2   Mycobacterium smegmatis MC2 MSMEG0667 TIGR 
MTFGCMTPPEGLGLALFRPECIQDPYPLYRRMLDTAPVHPIADSGFYAVC
GWDAVNDAIARPENFSSNLTATMTYQADGTVGAFEMESLGGKSHVLATAD
EPAHTAHRKALLPQLAARRIRAFEPFILETANSLWHSHLHDGHIEWMSAV
ANRLPMMIVGRLIGVPDADVDKLVRWGYSATQVVEGLVGQDQLTQATVAV
MELAGYITDQFRHAAQDPQDNLLGDLATACATGEMDELTAQSMMIILFSA
GGESTASLIGSAAWILASRPDIQEHLRAKPELLGAFVEEVLRYEPPFRGH
YRHVVHDTTLGGVDLPAGSRLLLLWGAANRDPSHFDAPDEFRLDRSSAKS
HLSFGKGTHFCVGAALARLEALVVLRHLLHNTANITAGDTGPWLPSLLVR
RLAHLELVTT

>CYP144A3   Mycobacterium vanbaalenii PYR-1 ZP_01207741.1, EAS22731.1 
MTVGHTDLGLALFHDEFLQDPHPLYARMHAEAPVHRVGDSDFYAVCGWDAITEAVARPGDFSSNLTGAMR YQADGTVSLLPLDTLGSPTQALATADDPAHAAHRKLLVPYLAAKRVRALETFAENTMHALWQQMPAGAPV EWMAVVADRLPMTVVCKLIGVPAEDVDRIAAWAYASTQILEGRVDEHTLTAAGTAALELAGYISDKLGRA SLDPGDNLLGCIATACAAGELNNLTAQVMLVTLFSAGGESTAALIGSATQIIATRPDVQRRLRADPGLIP AFLEEVLRFEPPFRGHYRHVVRDCALAGKELTAGSRLLLLWGAANRDPARFDAPNEFQIERPNSKAHIAF GKGAHFCIGAALARFEARIVIDLLLRHTSWVDAAGPGWWLPSLLVRRLDELPLTMT

>CYP145A1 AB000735 Nocardioides sp. 32% with B.s. 109B1
MSSVLAPESDVDLFAGEVLADPYPIYAALRSLGPVVWLPRHGFY
VVVRYAEAREVLNDHERFVSGRGVGFNQQFNDVRSGSIIASDPPRHDILRSVLNERLG
PRALKDTEVMIRSRASDLVAEMAQRRSFDAVKDFAEVFPVQVVGELIGLPEGSRGRLL
QWANGAFNAFGPSGERTAAGLEAIAEQFDYIRTVANREQLMPDSMGAAVYQAADEGII
SEDDCLPLLSAYLTAGMDTTVNALSAMLLLLSTDPDQWQELRSSPSLAPSVVNEVLRI
EAPAQLFSRVTATRVDLAGTRIEAGERVAVIYASANRDEKKYPDPDRFDIRRNPAGHL
AFGSGLHVCAGQFLAKTELRAVLDALIEQIETMTVGEPVRKINNVLRGLSSLPATFVP
VQTSR

>CYP146A1 AJ223998 Amycolatopsis orientalis cosmid PCZA361 2 genes
MQTTTAVGDLGNPDLYTTLDRHARWRELAARDAMVWSEPGSSPT
GFWSVFSHRACAAVLAPSAPFTSEYGMMIGFDRDHPDKSGGQMMVVSEQEQHRKLRRL
VGPLLSRAAARKLSERVRTEVSGVLDQVLDGGVCDVATAIGPRIPAAVVCEILGVPAE
DEDMLIELTNHAFGGEDELFDGMTPRQAHTEILVYFDELITARRERPADDLVSTLVTD
DELTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTGLQDGSADVDTVVEEV
LRWTSPAMHVLRVSTDDVTINGQDLPAGTPVVAWLPAANRDPAEFDDPDTFLPGRKPN
RHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVELVKEPAWLRAIVVQGYAELSA
RFTGR

>CYP147A1 AF111947  Myxococcus xanthus Partial missing C-term 
MAQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTY
DEIVALLHDPRVSSDIRNLVRQAGATPSPQEGPPGLPEPFIRRDPPDHDRLRKLAMRP
FGRTPPDALMPFVPGWSRPRRACLTRSRARTKSTSSDDVAYPFPVTVICKLLGVPRED
EARFHELADAGVETLDPTTGTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSG
FLTDNGPDGRMSREEVLSTAALLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPEL
SIPLVEELLRYEPPVQFLPDRVTLADIDIAGTTIPQG

>CYP147B1 SAV584 AP005023 Streptomyces avermitilis
MASDTLLARITDYANRPDPYPLYAELREAGPVVRQADGSYLIGT
YHEIVALLHDPRMSADPRSRTAPAPYEVTRKPSFLRLDDPEHHRLRNSAMRPFGPPHS
PGRVDSMRGEIVQLTKELAEVFQEGRQIDVVDDFAYPLPVTVICRLLGIPDKDEQLFQ
DWTDTLVASADIGPEGDTAERDQAADQAQQEMGQYLVQLAEQRRGRPTGDMLSDLVNE
PDPAARLSEEDLAANTILLFIAGHETTVNLIANGVLTLLRRPDQLDRLREDPSLLPRA
VEELLRYEPPVHMRERVPLVDIDVAGTTIPGGTSVILALASGSRDPMRFSEPDRFDPT
RPDNQHVGFGSGIHLCFGAPLARIEAEAALGALLPHLGTARLVQDPPPYRQNAMLRGP
RHLPIQL

>CYP147D1   Magnetospirillum magnetotacticum GenEMBL NZ_AAAP01002628 
MCAPGPGRDPQCGTGRSSSGDPPDHDRLRGQVMRCFTPQRVRGM
REKTRRITDDLIAKMAGKTRIDLVDDFSYPLPVTVICELLGVPPEDEAQFHGWATQLA
TALEPNQRGDEETQAKNEVCFNEIADYIQGLIKEKRKNPQEDILSDLATDTDGMNDFD
LIATAVLLLVAGHETTVNLITNGMLTLLRFPEHLERLRAEPETAPRLIEELLRYEPPV
HYRTRLALADIPVAGITIPKDAPVILLLAAANRDPLRFSDPDRFDPDRPDNRHLGFGG
GLHYCVGAPLARIEAEVALVSLVRRLKGLSLTENPPPYRPGASLRGPCHLRLALEEVAEG

>CYP147E1   Methanosarcina barkeri Archaea GenEMBL NZ_AAAR01001943 4935..6305
MYRQGSGPNDRRQTMTQQSLYEQVLDYANRANPYPLYAKLRQTP
ITRQIDGSYVVSTYREIVSLLHDPRIGSDFRMRSA
HDRPSAGLSANQELASKNQAQDEGAETSSSNQGSETEVV
PSFIGLDPPEHDRLRRQATWPFGPPHTPGRVADMEPELILLA
NRQIDTIKGRTSIDIVEDFAYPIPVTMISELLGVPPEDQPRLHALSEAIIEDIDLDPR
QSPEEQKRRQEQSSQTFKELEQYMEVLIEHHRKQPGSDLLSGLITDHGSDGPMAQADL
VSTASLLLIAGHETTVNLITNGMLTLLRHPDVLERLRREPDLVIRLVEEFLRYEPPVQ
ILPNRVALSDITIAGTTIQKGSPVILLLASGSRDPARFHDPEKFDPDRRDNMHLGFGS
GIHYCYGAPLARLETQIALTELVQRLENPRLAHDPPPYRQSATLRGPRHLIVEIDGVK
DWEFHL

>CYP147G2   Mycobacterium vanbaalenii PYR-1 ZP_01203548.1, EAS24540.1
MTTASQAWAQAMAFAHRADPYPFFAELRKTPVARVADDLYVVTGYYELLALAHDPRVSSDFRRSPLSSDR APAEPADDVGAYGSEPSLIVTDPPSHDRARRQVSRHFAPPHSPDLIPSMEPAVVALCNDLLDTAKANGRT RIDVVDDYAYPVPVMVICKILGVPLEDEPRFHAWIFDMLAGVDLGPDATTDEGQGRAARARDAQAALRDY LAGLIEGYRGAGGDGLLSALVNDASGPDGAMPPGQALANAVLLLIAGHDSTVNTISNCVLTFLRNPGTVE LLRDRPELIPRAIEEVQRLQSAVQFFPSRSATADIEVGGTVIPEGAAVHLMYGAANRDPRRFADPDTFDI FRPDNEHFGWGSGIHTCVGGPLARLEVNLALEIFLRRVHRPRLVSDPPPYRQSQIFRGPRHVLVDVEAIG D

>CYP148A1 AE002083  Deinococcus radiodurans R1 
MTASSGSSAPSSGPLLAAVQGLWSGAALADPHPIYEQIRGFANA
DGLVRLPEWNTAFAVGHAATSAVLRSPAARSGEWDHGPSDGGKLLQHMMLFRNGIPHA
RLRGLVQKAFTPRVVEEQRDLVRSLLDELLSDMARAGGPVDLVAGLSGPLPGRVIMRM
LGLRGADEERFLGWSASVAELLGGADRSPALLARIEADAREMRGYFRDLADELRVSPQ
PGLLSALAAVEDGGERLSGDELLSNAVLLLAAGHETTSNLIPGGVLALSQQPGAWAAL
LNHPRHPGVADELLRHVSPVQLDGRMLTEAQTVGETPLPAGTPVQLLLAAANRDPQVF
PDPERLDWDRPNASRHLAFAAGPHYCLGASLARLEIAETFAALAERFPDLRVSAAPHY
KANFVLRGPQELWVTLG

>CYP149A1 AB036790  Microcystis aeruginosa 
MIKQPIAIVGMGCRFPGANNPSEFWEILQNGVHKITKDPIDRPT
QMTGWAGFLDGIDKFDAAFFGIYSEEAIKMDPQHRLLLETSWEALEDAKLVPANLAGT
DTGVFIGLSGSEYPNLLIEDSTFNTTIGTLDCMLANRISSYFDFQGLSITINTACSSV
LVAIDSACQSLWNEDICLALVGGTHLTFSPVIASRASLNAMRPKIQAIVDDLLDRFAP
RGEMEIIADFATPLPAFAITKILGLPIEDYQQLIRWSAKTVFIFDQPVSLEEYKEQNQ
ILIEHRAYFAQKVAEYKRQPNDGLISQLANYNDNINALTEDEIISTSILLIATSQESM
KGLLSNGLLALLKHPQSLEYVRQNPGNIENIVEELLRYDSPIQYVSRRAIEDVEVSGK
IIHRGEYVVIYLGAVNHDPEYFSNPQQLDFSRRKPNLGFGGGLHYCVGMFLARLQVQI
ALNAMVQRFPDICLNTDKLDWCDSKISRRLKTLPVKFTPVA

>CYP150A1 Mycobacterium species AF107046 
MSDFDTIDYFTDPALVPDPHPYFDHLRAQCPVVKEPHYGVLAVT
GYDEAATVLKDNETFSSCIAVAGPFPPLPFTPEGDDITDQITAHRPQMPMFEHMVTMD
PPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDFVTDGRCEFLTAFAKPFSLLV
IADMLGVPEEDHDEFRAVLGAPRPGANVGSLDHSDLVGTNPLEWLDEKFIGYLEDRRR
EPRNDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASMRVLGDHPDV
QERLRRDRSRIPVFVEEALRMDAPVKSQFRLAKKNTKVGDMNVPAGTTMMVCPGAVNR
DPNRFEHPHEFDLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMADIQID
EELHGPPGARRYTYEPTFILRGLTDINITFSPVG

>CYP150A2 Mycobacterium smegmatis AF107047 
MTDSTATDPAATTPDFDTVDYFTDQSLVPDPHPYFDHLRSKCPV
VREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPFPPLPFTPEGDDITGQIEQHRT
QLPMFEHMVTMDPPEHTNARSLLNRLLTPKRLKENEDFMWRLADECLDDFIDDGSCEF
LKQYAKPFSLLVIADLLGVPEEDHDEFRHVLGAPRPGAIVGSLDGDQLAMNPLAWLDD
KFVRYLEDRRKEPRDDVLTALATAKYPDGSTPEVIDVVRSATFLFAAGQETTTKLLSA
SLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAKKTTQLGGVDVPAGT
TLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSLER
ILDRMADIRIDEEHHGPADNRRYTYEPTYILRGLTDLHIKFEPVR

>CYP150A3   Mycobacterium smegmatis MSMEG4812 TIGR 
MAIDPAGIDWFKDPRLVDDPYPYFNALRDKCPVQSEDHYGVTMVTGWEEA 
VSVYNDEKSFSSCTSVTGPFPGFPVPLEGRDDVAELIEKHRDELPFSDQL 
PTLDPPVHTNHRSLMMRLITPKRLKENEDAMWQLADEVLDDFLAPGKGEF 
IKGFASPFTLLVIADLLGIPAEDRNAFVDGISQNSGGGVGSTGDESLSHS 
PLEFLYGQFEAYIEDRRSNPREDILTGMATALFPDGTTPSPGDVARVATN 
VFSAGQETTVRLLGTALKVLGDRPDVQKMVREDRSLLPNFIEEALRHESP 
VKGDFRLSRCPVTVGDKDLPSGRTVMVVNGAANRDPRRFENPDDFDPARK 
NARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTTDIRISEEHHGPAA 
NRDYKYIPTFILRGLTHLHLEFDVK

>CYP150A4   Mycobacterium smegmatis MSMEG5988 TIGR
MTDLASVDYFSDPAVAQDPYEYYDFLRSRGPVTTEPHYGVVAVTGYQEVM
AAFKDHDSFSAVNAIGGPFPPLPFTPEGDDITEQIEAHRHLFPIHEHMVV
MDPPAHERARSLLSKLLTPRRLKENEDFMWQLVDRQLDAIIGNQADEGRC
EFLSEYAKPFATSAIIDLLGVPEEDRAEFLEALGAAPREGARVGALDGEP
VGLDPLQYLDCKFAGYLAERRREPRGDVLSGMATATYPDGSTPDLMEVVK
PATFLFAAGQETVTKLLSSAVQTLAERPEFQERLRKEPDLIPVFIEEALR
TQSPTKVDFRLARKTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFR
IDRPNVREHIAFGRGIHTCAGAPLARVEGQITVRRMLDRLRDIRIDATRH
GPADSRTYAYEPTFLLRGLTKLHIEYTPA

>CYP150A7   Mycobacterium vanbaalenii PYR-1 ZP_01205741.1, AAS77249.1, EAS26733.1 
MSDFDTIDYFTDPSLVPDPHPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPFP PLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDI ISRDPVGRCEFLSAYAKPFSLLVIADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANPLEWLDE KFIGYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASLRVLGDHPDIQ ERLRRDRSRIPIFVEEALRMDAPVKSQFRLAKKNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDL DRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPTFILRGLTD LNITFTPVR

>CYP150A8   Mycobacterium vanbaalenii PYR-1 ZP_01207544.1, EAS23103.1 
MTDLASADFFSDYALSQDPHPYWDHLREQNPVYREPHYGVVAVTGYQEVLAAFKDHDSFSAVNAIGGPFP PLPFTPEGDDITEQIEAHRHLFPIHEHLVVMDPPAHERARSLLNKLLTPRRLKENEDYMWQLVDSQIDQV IGKGRCEFLSEYAKPFATSAIIDLLGVPEEDRPEFLAALGAEQPDGARVGALDGEPVGLDPLQYLDDKFA GYLAERRREPRGDVLSGMATAVYPDGSTPELIEVVKPATFLFAAGQETVTKLLSAAVKTLAEQPEYQRIL RAHPDRIPTFIEESLRMNAPTKVDFRLVRKTTTLGGVHLKAGTIVMLCLGAANRDPRKFEDPHEFRPERK NVREHIAFGRGIHTCAGAPLARVEGQITVRRWLDRTDEIHLDESVHGPAGQHHFAYDPTFLLRGLSQLNI EFTAAT

>CYP150A9   Mycobacterium vanbaalenii PYR-1 ZP_01205777.1, EAS26769.1
MAEDLTTVDFFRDSRLTDDPYTFYEALRNKCPVSREEHYGVTMVTGWQEAVDVYNDAESFSSCVSVTGPF PGFPVSLEGRQDDDITALIEQHRDEIPFSDQLPTLDPPTHTNHRALLMRLITPKRLKENEDAMWQLADDI LDDYLAQGEGEFIKGFAGPFTLRVIADLLGVPEEDRPELLERLAKGTHGGGLGNADKTLTKTPLEYLYDV FATYVEERRAEPRDDVLTGLATANFPDGTVPEVGDVVRVATNVFSAGQETTVRLLSTALKVIGDRPDIQE RLRADRSLLPNFIEECLRIESPVKGDFRLSRVPTTIGDQALGAGCTVMVINGAANRDPRRFEDPDAFDPE RKNARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTSDIRISESKHGPAGNRRYDYIPTYILRGLTEL HLEYDVR

>CYP150A10   Mycobacterium vanbaalenii PYR-1 ZP_01205906.1, EAS26898.1 
MTEQLTPTDIDEVDFFTDNTVLHDPYGYLAAMRNECPVRRERHHDVVMITGYEEAVAVYNDNARFSSCTA VTGPFPGFPVPLVGDDVSGLIAEHRDKLPFNDQLPTLDPPLHTDHRALLSRMITPKRLKENEEFMWRLAD RQYDEALAGGRCEFVGEFGNPFAMLVIADLLGVPESDHNDFKDQLLTSTGTIGSSGGDAMHHSPLEYLYG KFTDYITDRRENPRDDVLTGLASALFPDGRTPPVIDVVCVAANLFAAGQETTVRLLSTAVMMIAEDPALQ AKLRADRSLIPGFVEEALRFESPIRGDFRLSKVPVSVGGVELPAGTTVMLNNAAANRDPRRFTDPDTFDL QRPNARQHIAFGRGAHSCPGAPLARAEAKVSINRLLDRTSDIWIDEDKHGPVDARRYKYLPTFILRGLTR LHIEFS

>CYP151A1 Mycobacterium smegmatis AF102510
MSSTTLDSVPSFDVTDPAFSITSDEVHEAREKSWYATTPYGLAV
LRYEQVNRLIKHPKLRQGSAAWPAHNGVTEGPFAEWFASWILNKEGEEHHRLRRLMNP
AFSPKLIGSLVPRFQALANELIDNFAEPDRCEFVSEFAEPYAARVIAIMLGLPEEEWK
VISTESATIGLALGVTLREDLPKIEAAVQRLYEYSDELIADRRANPRDDFMTTLVNAS
RPDDGRLSDKELRDAILLLIFGGFDTTRNQLGLAMQTFMKHPDQWRLLGERPDLGGKA
VEEVMRVNPTVRWVTREVVEDFEYEGVTLKAGTTVHLYSESAGTDPRVFEPGFDITAE
RKPHFGFGGGVHHCLGHFVARSDMSEALPLLARRLRDPHELPGATWLPDSGNTGPNTL
PIGFTPAP

>CYP151A2     Mycobacterium sp. strain RP1 AJ310142
MSSLALGPVAAFDVADPSFSITSNEVHAARERSWYATTPYGIAV
LRYEQFSRLLKHPKLRQGSVAWPAHNGVTEGPFAEWFASWILNKEGEEHHRLRRLMNP
AFSPKLIGSLVPRFQALANELVDNFAEPYRCEFMSEFAEPYAARVIAIMLGIPEDEWK
VISTEAATMGLCLGVTLGKDLPKIEAALQRLYEYCDALITDRRANPREDFVTALVEAS
REEDGRLSDTELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGKA
VEEVMRVNPTVRWVTREVLEDFEYEGVLLKAGTTVHLYSESAGTDPRVFDGSFDITAE
RKPHFGFGGGAHHCLGHFVARSDMSEALPLLARRMRDPQALPGATWLPDSGNTGPIQL
PIGFTPAR

>CYP151A3    Mycobacterium vanbaalenii PYR-1 ZP_01205617.1, AAS49915.1, EAS26609.1 
MSSATVGSVPAFAVTDPGFSITSAEVHAARERSWYATTEYGLAVLRYEQVNRLLKHPKLRQGSAAWPAHN GVTEGPFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRFQALAAELIDGFAEPGRCEFVGEFA EPYAARVIAIMLGLPESEWKVIATESATIGLALGVTILDDLPRIEAALAHLYEYCDELIADRRASPRDDF VTTLVNASRPEDGRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGNAVEEV MRVNPTVRWVTREVLEDFEYEGVELAAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGVHHCLG HFVARSDMSEALPLLARRMLDPHELPGATWLPDSGNTGPITLPIGFTPAS

>CYP152A1 Bacillus subtilis AB006424 ybdT gene
MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK
NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL
MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK
ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA
FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER
EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF
RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS
LHYSLARMPSLPESGFVMSGIRRKS

>CYP152A2    Clostridium acetobutylicum GenPept AAK81262                 
1 MLLKENTAKD KGIDSTLDLL KEGYLFIKNR ADHYQSDLFE TRLMGQRIIC MTGEEAARIF
 61 YDSDKFKRQG AAPKRVQETL LGENAIQTLD GESHLHRKKL FMLLTNQVQQ KRLAELTTEK
121 WEASASKWHT KSIVLFNEAN EILCQVACHW AGVPLMESDI KNRAEDFSSM IDSFGAVGPR
181 HWKGKKARNT IEAWIKEIIE NVRSGRIRAE EGSPLHEIAF YIDVNGQQMP AEMAAIELIN
241 ILRPIVAIST FITFSALALY EHSEYREKLQ SKDIRYLEMF TQEVRRYYPF APFVGARVRK
301 DFLWNNCEFK KEMLVLLDIY GTNHDSRIWQ KPYEFIPDRF RSYKGNLFDF IPQGGGDPSS
361 THRCPGEGIT LEIMKTSLDF LSTKIDFTVP DQDLSYSLSK IPTLPKSGFI IDNINLKL

>CYP152B1 Sphingomonas paucimobilis AB006957
MPKTPHTKGPDETLSLLADPYRFISRQCQRLGANAFESRFLLKK
TNCLKGAKAAEIFYDTTRFEREGAMPVAIQKTLLGQGGVQGLDGETHRHRKQMFMGLM
TPERVRALAQLFEAEWRRAVPGWTRKGEIVFYDELHEPLTRAVCAWAGVPLPDDEAGN
RAGELRALFDAAGSASPRHLWSRLARRRVDAWAKRIIEGIRAGSIGSGSGTAAYAIAW
HRDRHDDLLSPHVAAVELVNVLRPTVAIAVYITFVAHALQTCSGIRAALVQQPDYAEL
FVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRP
ERFRAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDVPDQDLS
IDFARLPALPKSGFVMRNVHIGG

>CYP152B2    Azotobacter vinelandii NZ_AAAU02000007 102969-104183
MHRIPRDKGLDSTLALLHDPYRFIARRCRLHGSNLFETRLLLRKTLCMSGAEAARLFYDP
ERFVRHGAMPPRLQKTLFGVGGVQGLDGEAHRHRKHMFVALLMDAERVAQLVEAVRGEWR
TCARRWERMEKVVLYD 
CAWAGIPLAEEEAGPRAREIALLFDYAGSVGPKHWRSRLARRRSEAWMGALVESIRASRR
QPPAETAAQVISWHRGLDGNLLEAR
VAAVELLNVIRPVVAIAVYLTFVAHALHRYPHCRHGLRSGDAEYREWFVQEVRRFYPFFPA
VVARVRQDFEWRGYAFPAGRRVMLDLYGTDHDVRLWQAPETFRPERFGSREYGPCDFIPQ
GGGEHESGHRCPGERIVMKLGADVLARELSYAVPMQNLEIDFSRLPALPRSRFVMSDIHGAP*

>CYP152C1   Rhodobacter sphaeroides GenEMBL NZ_AAAE01000129 
MTTDEGRRPEEPGTPASLREMPRDPRIDASMALMSEGYRFVSNL
CDRMDSDAVATRLRLREVVCLRGSAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQ
LEGPAHRHRKALFLSICMDPARVEALVSEMRLAWRERLPAWEAEGRIVLQQEAARLLT
RAGCRWAGVAHQPEAQLADEIFDMIDKAGSVGPRNWLAQMRRAGTEKRLRTLVEEVRA
GEVVPEAATALHAIAFHREEDGTLLDPSVAAVELLNLLRPIVAVGRYITFAALALHRE
TTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPITWEGYDFPEGQWLLLDLY
GTTHDPRHFPEPTRFRAERMLSWTGQDEAFIPQGAGDVARTHRCPGEMITVELMKEAI
RLLCCEMDYEVPAQDLGVRLNRMPAQPRSGMILSAISRRAGTEASRNG

>CYP152C2   Rhodobacter sphaeroides ZP_00915817, EAP62861.1
MSNSDARHEA GPSDTTCGRE IPRDPRLDAS MGLLSEGYRF VSNLCDQLDS DIVSTRIRLR
EVICLRGGTA ARLLYGAEGL TRVGAMPSSV LHLLQDKGSV QQLEGPAHRH RKALFLGICM
DPARVEALVA EFRAAWRAAL DEWEEADSIV LQQEAARVLT RAACRWAGVE NQPEARLAEE
IFDMIDKAGS IGPRNWLAQM RRSGTERRLR KLIEQVRAGE VVPGSATALH AIAFHREADG
ALLDDTVAAV ELLNVLRPIV AVGRYITFTA LALHRETNWR DLFRSGTLEL AADFAEEVRR
ISPFFPFTAA VTTRPLQWEG YDLPADQWLL LDLYGTLHDA RNFPDPARFR AERMLSWSGQ
DDCFVPQGGG EVAVTHRCPG EMITVELLKE AIRLLCLEMD YEIPPQDLGV RLNRLPAQPR
TGMVLASIRR RPGTEPCVAG

>CYP153A1 Acinetobacter calcoaceticus AJ311718.1 Acinetobacter sp. EB104
MNSVAEIFEKITQTVTSTAADVATTVTDKVKSNEQFQTGKQFLHGQVTRFVPLHTQVRGIQWMQKAKFRVFNVQEFPAFIEQPIPEVATLALAEIDVSNPFLYKQKKWQSYFKRLRDEAPVHYQANSPFGAFWSVTRYDDIVYVDKNHEIFSAEPVIAIGNTPPGLDAEMFIAMDPPKHDVQRQAVQDVVAPKNLKELEGLIRLRVQGVLDQLPTDQPFDWVQNVSIELTARMLATLFDFPYEKRHKLVEWSDLMAGTAEATGGTVTNLDEIFDAAVDAAKHFAELWHRKAAQKSAGAEMGYDLISLMQSNEATKDLIYRPMEFMGNLVLLIVGGNDTTRNSMTGGVYALNLFPNEFVKLKNNPSLIPNMVSEIIRWQTPLAYMRRIAKQDVELNGQTIKKGDKVVMWYVSGNRDERVIERPDELIIDRKGARNHLSFGFGVHRCMGNRLAEMQLRILWEELLQRFENIEVLGEPEIVQSNFVRGYAKMMVKLTAKA

>CYP153A2   Caulobacter crescentus CB15 GenPept AAK22050                 
1 MMSQNTDPRE DLMSDGSIDL KADARARAYS IPLEDYHVAD PALFQADAMW PYFERLRKEA
 61 PVHYSKGDEE VGPYWSVTRY NDIMTVDTTH QVFSSDAHLG GITIRNFDED FVLPMFIAMD
121 QPKHDIQRKT VSPIVSPANL GRLEGIIRER VCGILDALPI NEPFDWVDKV SIELTTQMLA
181 TLFDFPWEER RKLTRWSDIA TASPESGLIE SEEARRAELL ECLAYFTNLW NERVNLTEPG
241 NDLISMLAHG EATRDMPPME YLGNVILLIV GGNDTTRNSL TGGLYALSKN PQEEAKLRAD
301 PGLIPNMVSE IIRWQTPLAH MRRTALEDYE LAGQTIKKGD KVVMWYVSGN RDDTVIENAD
361 QFIVDRPNAR RHLSFGFGIH RCVGNRLAEM QLKIVWEEIL KRFPKIEVLE EPKRVYSTFV
421 KGYERMMVRI PERI

>CYP153A3   Bradyrhizobium japonicum USDA 110 GenPept BAC52507                 
1 MHYCKDSMFG PYWSVTRYND IMEIETNHSV FSSASALGGI TIRDIDPDLR RESFISMDPP
 61 RHAAQRKTVA PMFTPTHLDN LALNIRARSA ECLDNLPRGE VFDWVDRVSI ELTTQMLAVL
121 FDFPWEDRRK LTRWSDIATT IPGPDGLVAT EDERQAELTE CAGYFARLWK ERIEQPPKSD
181 LLSMMAHGAA TRDMDAKNFL GNLVLLIVGG NDTTRNTMSG SIYALSQHPE QYRKLRENPA
241 LLDSFVPEVI RWQTPLAHMR RTALSDFEFR GKQIKKGDKV VMWYVSGNRD EEAIEKPYDF
301 IIDRARPRTH LSFGFGIHRC VGLRLAELQL KIIWEEILKR FDHIDVVGEP KRVYSSFVKG
361 LETLPVKIAA

>CYP153A4   Bradyrhizobium japonicum USDA 110 GenPept BAC52508                 
1 MDGRRRRPMP LPQAGEVRKT TGATTMNIQT PVKVDKAERM RRARGEAYAT PLAQFHPGAP
 61 RLFQDDTLWP WFERLRKEEP VHYCTNAPIE PYWSVVKYND IMHVDTNHGI FSSDSTLGGI
121 SIRDVPEGYD YPSFIAMDQP RHSAQRKTVS PMFTPTHLDE LAKLIRQRSQ TVLDNLPRNE
181 TFNFVERVSI ELTTQMLATL FDFPWEERRK LTRWSDVSTA LPKSGIVASA EERRREMDEC
241 YAYMSKLWNE RVNSAPRNDL LSLMAHNDAT RFMDPDNLMG NIILLIVGGN DTTRNTMTGS
301 VLALNENPEQ YDKLRANPAL IDSMVPEVIR WQTPLAHMRR TALQDTEIGG KQIKKGDRVV
361 MWYVSGNRDE EAIDRPNEFI IDRPRPRTHL SFGFGIHRCV GMRLAELQLK IVWEEMLKRF
421 DRIEVVGEPK RIYSSFIKGY ESLPVRIPG

>CYP153A5   Rhodopseudomonas palustris NZ_AAAF01000001 
MTWPGRTTMHGTIETGKAARLRAAREEAYATPLKDFHPGAPRHF
RDDTLWPWFERLRAEEPVHYCTNAPIEPYWSVTKYNDIMHVDTNHQIFSSDSTLGGIS
IRDAPVGYDWPSFIAMDEPRHSAQRKTVSPMFTPQHLDELAVLIRGRTQKVLDGLPRG
ETFNFVDRVSIELTTQMLATLFDFPFDERRKLTRWSDVATALPKSGVVDSEQQRRDEL
NECAAYFARMWNDRVNSEPRNDLLSMMAHHDATRTMDRDNLIGNILLLIVGGNDTTRN
TMSGSVLALNENPHEFEKLRANPKLIDTLVPEVIRWQTPLAHMRRTALQDAELGGKTI
RKGDRVVMWYVSGNRDDEVIERPEEFIIDRARARIHLSFGFGIHRCVGMRLAELQLRI
VWEEMLKRFERIEVVGEPKRVYSSFVKGYESLPVRVS

>CYP153A9   Bradyrhizobium japonicum USDA 110 GenPept BAC47118                 
1 MNRRLEIHRA DDGYIIPLSE LDVSEGKRFQ DDSIWGCFER LRREDPVHYC QNSAHGPYWS
 61 ITKYRDIVAV DTNHHAFSSQ QGVTIVEVPD KHWTPSFIKM GPPQHAEQRN TVSPIVGPES
121 LTRLETLIRS RVRMILDGLP RNEVFNWVTK VSIELTTQTL ATLFDFPFED RRLLTYWSDA
181 AVTTPKAGYA IDSWDKRSTI LSECLDYFTR LWNERINAEP RLDLISLMAH SPVTRHMEPT
241 EFLGNLILLI VGGNDTTRNS ITGGLLFMSQ YPSELRKLTD NPKLISSAVS EIIRYQTPIA
301 HMRRTAAIDS IVGGKPIRTG DKVVMWYISG NRDEEVIENA NSFVIDRKNV RQHLSFGFGI
361 HRCLGRHLAE LQLRVLWEEI LDGGLKIKVV GEPERIASNF VHGYSALPVR IEA

>CYP153A10   Burkholderia fungorum NZ_AAAJ02000161
MRHVSCLRRSRLERSRGRARRPGGFHADLFTDPQGQLAALLPDR
GARGTRRTGPAPSRRPALTTLARHSNPVPDKALAPLTRNCHSAKVNCMNTLVVDSSHV
RLAPDALSQPVEDIDPSLPYRFQQQTHFAMFDRLRRESPVHYVKDSEYGPFWSVHRYN
DIIDVEIDHATFSSDVKYGGMLIKDLPENMRRTSFINADPPLHDHQRRVVSPIVAPGN
LNRLEHTIRREAADILDGLPRGETFDWVDNVSIELTGRVLCELMDFPRADRRLLTYWS
DIVNVDLEVGGEINTEEKRYVKLKECASYFGVLFKERMNSEPKDDLISMLAHSEYTKN
MPEQEFLGMIVLLMVGGNDTTRNSISGGLVALNQFPEQYAKLHNDPGLIPKLVPEILR
WVTPVTHMRRTATRDIEFRGKQIRQGDKVVVWYASGNRDSDVIKDPYQFIIDRANPRL
HLSFGFGIHRCLGNRLAELQLRVLWEEILKRQMLIEMMGEPVRKYANNITGVMALPVR
IAA

>CYP153A13a Alcanivorax borkumensis Strain SK2 AY505118.1
MSTSSSTSNDIQAKIINATSKVVPMHLQIKALKNLMKVKRKTIGTSRPQVHFVETDLPDVNDLAIEDIDTSNPFLYRQGK
ANAYFKRLRDEAPVHYQKNSAFGPFWSVTRYEDIVFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRRAVQ
GVVAPKNLKEMEGLIRKRTGDVLDSLPLDTPFNWVPVVSKELTGRMLASLLDFPYDEREKLVGWSDRLSGASSATGGEFT
NEDVFFDDAADMAWAFSKLWRDKEARQKAGEEPGFDLISMLQSNEDTKDLINRPLEFIGNLALLIVGGNDTTRNSMSGGV
LALNQFPEQFEKLKANPKLIPNMVSEIIRWQTPLAYMRRVAKQDVELNGQTIKKGDRVLMWYASGNQDERKFENPEQFII
DRKDTRNHVSFGYGVHRCMGNRLAELQLRILWEELLPRFENIEVIGEPERVQSNFVRGYSKMMVKLTAKK

>CYP153A15  Hyphomonas neptunium gnl|TIGR_228405|contig:1062
859136 MAADTVSFVNHPALERPKVTEREPLHPHNLRFGANIPPAADIDLSTLDLIDGELWRQGKY 858957
858956 WDRFERLRNEDPLHYCPDSFPGPFWSVTRYEDVMAIDTDHKRFSSSWEYGGITLGEPISD 858777
858776 FEMPMFIAMDEPRHSEQRKTVQPAVAPDMLKVYEPLIRSRTQGLLDSLPVNEPFDWVDKV 858597
858596 SVELTTMMLATLFDYPFENRRDLTHWSDVATGMHNPDICPGGEEEWKATMMKCLMTFMGI 858417
858416 YQERQQQPQKPDLMSLLAHGEKTKNMTPMELLGNVILLIVGGNDTTRNSMTASVFALNKF 858237
858236 PKEYEKLKADPSIIPNMVSETIRWQTPLAYMRRTALEDVEMHGKTIKKGDQVAMWYVSAN 858057
858056 RDERFWDKPNDFIADRPEARRHISFGFGIHRCVGNRLAELQLRILWEEIMERFEHIEVLA 857877
857876 EPSLNQNAFVKGYNWMPVVLHPK 857808

>CYP153C1   Novosphingobium aromaticivorans GenEMBL NZ_AAAV01000116
MAATLAPDRAINPHDVSLNALYTEDRWREPFRWLRENMPVSYRA
ESPFGAYWSVVTHDLIQQVELDPGTYSSSWQRGNITIADSVNETEFPNFIAQDPPIHT
AQRKVIAPAFGPSQMVKLERLVRERTTQLLDGLPMGEEFDWVERVSIPLTLGMLLILF
DMPFDEWRDIKRWSDWASGVSEDSLNDAYRAEFVQQMGQMLMRFDRELEARRALPPSD
DLLSRMVHSDAMGHLTPPERIANIALLIVGGNDTTRNSMSGLIEALHRYPAELDKLRA
DPALSANAAQEIIRWQSPVTHMRRTLTRDAELGGQRLAEGDKIVMWYISGNRDENVFP
DAERFDVTRENARRHIGFGHGIHRCVGARLAEVQIAAVIEEIATRRLRITPQGAPTRL
ASPFLHGFTAMPVVMSRD

>CYP153D1   Novosphingobium aromaticivorans NZ_AAAV01000178 
MATQLAPEVPQFTYHSSPTATEAFAAWLKDNPQAIPAHSHPWDV
SRSDIYVEDRWQPIFAEMRAKAPVNRVPDSPYGAYWNVASHKAIMHVESLPELFSSSW
QYGGITIGDPPEDVDPQKLAERQLPMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEI
RRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWAGDVEL
TLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGN
LVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLIPNAVQECIRYVTPLAHMR
RTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNARRHLSFGHGIH
RCVGARLAELQLRILLEEMHERRMRVRVAGEVERVRANFVHGFRKLEVELEKR

>CYP153E1   Erwinia chrysanthemi strain 3937 gnl|TIGR_198628|NC_003916 
4874678 MKMTKQLQDVFEDIDAVPLEKINPASRDRFINAAELPMFERLRREDPVHFTPESEFGPYW 4874499
4874498 SLTLWEDIRAVGNNYRDFTSTQNIDLKSIEEKIKLEAALQALGHERRKNVGFITMDPPEH 4874319
4874318 TKHRKAVTPAVGPSSLAQMEPIMRERAGIILDSLPIGEPFDWVDLVSKELTATVLATLLD 4874139
4874138 FPFEERRKLTFWSDLLMFEPGHGLVKSWEQKAEETVKCYQVFEALWEKRRNGPPSYDLIS 4873959
4873958 MLAHHPDTRDMTLEQFRGTIVLLIIGGNDTTRNTISSSLYLLDKYPEEFAKLKANPKLVM 4873779
4873778 PMISETLRFHPPVNFMSRVATRDVEIRGKNIKEGDRVVMWYTSGNRDASAIEDPDTFSID 4873599
4873598 RERARRHLSFGVGVHACIGSRVAEMQLTVIWEEILKRFSRIEVLEEPERSYSNFLHGFEN 4873419
4873418 LKVII 4873404

>CYP154A1 AL353832.1 Streptomyces coelicolor cosmid E6 MATQQPALVLDPTGADHHTEHRTLREGGPATWVDVLGVQAWSVS
DPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENMFTAYGPNHRKLRRLV
APAFSARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELAYPLPIAVIGHLMGVP
QDRRDGFRALVDGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAAR
DDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRKGEVTWA
DVVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADT
FDATRTVKEHLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPPVPS
LISNGHQRLPVLLHAG

>CYP154A2 SAV109 AP005021 Streptomyces avermitilis
MSEQQIIVLDPTGSDPDAEHQALRERGSAALVDILGVRAWSVSD
PALLKQLLTSKDVSKDGRAHWPAFAETVPTWPLALWVAVENMFTAYGDNHSRLRRMVA
PALSARRTAALQADIEALVNSMLDGLDAFPAGEVADLRKHLAYPLPIAVIGKLMGVPA
DRRTEFRTVVDNVFATHLSAEEQAANTAALYALLDALIEIRRAEPGQDMTSLLIAARD
EEDGSAFSDAELRDTLLLMISAGYETTVNVIDQAITTLLTDPCQLAHVREGRCTWQDV
VEETLRHQPAVKHLPLRYARIDIPLPDGQTIKTGEAILASYAAANRHPTWHEDADRFD
ATRPSKEHLAFGHGVHFCLGAPLARLEVATALRLLFERFPDARLATERTALEALPSLI
SNGHTSVPVHLRPTSSASS

>CYP154B1 AF145049  Streptomyces fradiae tylosin-biosynt. 
MAPDPVLVPRVGTYSMRPTERSARMETTSCPYALDPLGRDLAGE
AAMLRSQGPATWVELPGGVGAWAVTGHRYVKQVVADPRVSREARHWPAFTEGRITEEW
PLYYWVAAQNMMFSYGERHARLRRMVAGAFTVRRTEALRPRIEGLVGELLDGLAASPA
GEPVDLRASFAKLLPMRVICALFGVPEADRDTLCAEVDTTFNTAATPEETTASQIKVF
RMLAELIALKRAEPEDDLTSALIAIRDSGDRLTEDELIGTLNLMIAAGAESTVHLIGN
AVAALLTRNDQRDLVRSGRAGWEDVIAETMRTKNPAAYLPLRYAVEDIDLDGVPIRKG
DPILVSFAAPGLDPERHGDDAAEFDLLRAGRDNLGFGHGVHYCLGAPLARLEAGIALE
KLFERFPAMSLARPVESLEPLSSLIVNGYAALPVLLGPAAS"

>CYP154B2 SAV3704 AP005036 Streptomyces avermitilis
MAETAEAPGTAEAPGTAEAPGTAEAPETAEVSGTAEAPRTAETA
EAPETNGTNRVAEGVGAAGVTGMNQCPYALDVTGRDLAGETAQLRTRGPAVEVELPGG
VAAWAVVRQKYVKQLLMDARVSKDARQHWPAFVSGQIDEAWPLYPWVANENMLFAHGD
RHARLRRLNAAAFTARRTEALRPRVEEITAALLDGLADRPAGEQVDLRAEFAKLLPMR
VICELFGIAEANREPLCTALELVFGTAVPADEMAAAQVKVFGMLAELVAEKRERPGGD
LTSALIEARDGDDSRLTEQELLGTLYLMIAAGQETTCTLITNAVAALCAHPDQLSHVR
EGRADWADVVGETLRTHGPAAYSPMRFAIDDIELDGVHIKKGDPILVSFAAAAADPEP
YGADAAVFDVLRPGRRDDLAFGYGVHRCLGAPLARLEATTALSALFTRFPDLTSVQPT
EELEPVRSFIVNGYGSLPVVLRPH

>CYP154C1 AL158061 Streptomyces coelicolor cosmid 6D11 
MTTGTEEARIPLDPFVTDLDGESARLRAAGPLAAVELPGGVPVW
AVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHRR
LRTLVAQALTVRRVEHMRGRITELTDRLLDELPADGGVVDLKAAFAYPLPMYVVADLM
GIEEARLPRLKVLFEKFFSTQTPPEEVVATLTELASIMTDTVAAKRAAPGDDLTSALI
QASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEAEWS
AVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADR
FDLTRTSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKP
VVTQNDLFELPVRLA

>CYP154C2 SAV3882 AP005036 Streptomyces avermitilis
MTTRIALDPFVSDLEAESAALRAAGPLAAVELPGGVPVWAVTHH
AEAKKLLTDPRLVKDINVWGAWQRGEIAPDWPLIGLANPGRSMLTVDGADHRRMRTLV
AQALTPRRVEQMRERITKLTEELLDRLTGEVVDLKADFAYPLPMYVVADLMGIDEARL
PRLGELFEKFFSTQTPPAEVIATLTELAGIMAETVAAKRAAPGDDLTSALILASEDGD
HLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEADWSSVVEETL
RYSTPTSHVLIRFATEDVPVGDKVLPAGDALIVSYGALGRDEAAHGPTAGEFDITRST
ENRHISFGHGPHVCPGAALSRLEAGVALPALYARFPKLDLAVPAAELRNKPVVTQNDL
FELPVRLG

>CYP154D1 SAV1308 AP005026 Streptomyces avermitilis
MRGVPRAGRLVRRTAPTRRRSQETSLDTSSGTQPHRMDPAGGCP
HADNARLLARGAVAPVLLPGDIEGMAVLGHDALKEFLAHPEVAKNARHFTALQEGRTA
PGWPLLTFATVQGMTTADGEDHRRLRSLVSKAFTARRVERLRPWIEELTSALLDGLGR
AAEEGGQVADLRAHFALPLPMGVIGELLGVDAEHRDRLHHLSNQVVATDIGPEQAIAA
NRELVAVLSTVAAARAERPGDDLTSALIAARDEGGDRLSQQELIGTLVLMIIAGHETT
LNLITNAVRALCGNRDQLELVRKGDAGWPDVVEETLRWDAPVSYFPFRYPVRDLTVDG
TVIPAGTPVLAGYSAAGRDPAAHGPDADRFDVTRPARSETTRHLSLGHGAHYCLGAPL
ARMEATIALERLFTRFPDLELAVPEAELARHSSFVGNSVRALPVRPGVPRS

>CYP154E1   Thermobifida fusca GenEMBL NZ_AAAQ01000039b 
MGQSRRPHTVYLDPAKGVDIPAQRRELLDKGPVVRVAFPGNLEV
WALTHDAPLRNALADESVFVRGWRNWRALMAGEVDPTHPVANMLRVESMLARSGADHK
RMRGLVQAAFTRRRVEALRPRIEEITNELLDRMAESDGVVDLKAAYSFPLPIRVISEL
LGLNEEDHLTLQTLVTRTLSGTDPEANADAFTFVASLIEAKRKNLDDGLISAMIEARA
EDGDRLSETELIHNTLLLIIGGFETTMGMISNSVQLLLTHPDQLHLLRTGQASWENAI
EECLRFESAVVMLPFLYTTRDVEIDGITIPAGDAVLIGFGPANRDPQAYDDPDRFDIT
RPRPRHLAFGHGAHLCLGAALARLELLIALPALFERFPDITLVGEAPPTPTVFMNHPL
SRPVLLRPKP

>CYP154F1   Thermobifida fusca GenEMBL NZ_AAAQ01000042a 
MAVSADHAAAGALPGARHPAGRRVRAGRRLLDHRLRSGTRRPGG
CPVHRPAQPVRDPRPPGVGDRAPRVPGAADLPADRGRRGECAAGPVAGRASRGSPRVA
GAAPFPVRPRTQGASCHLHPRRHHPTNGGT

MAAVPEPIVLVPGKSREQALQLREAGPL
ARVVVEGLEVWALTHDRELREALIDPRFRRNWRTWRALNEGEVATDHPVAAMVYLDNM
LTVDGEAHRRMRSPVAQAFTPRRVELLRPRVTEIVNALLDQLAERDGTVDFKTEFAYP
LSMRVFSALFGIPERDHGRMQQMVNTAFSPSSPEEVRAMREELDAFLDELIEDKRRSP
GEDLTSALVTATDEEHKLSDAELRDTLWLLVTAGFETTSSALANAVQTLLTHPDQLAH
LRSGSIAWEDAIEEVLRQSSSVATLPFLFAAEDVQIGDRTIRAGEPVLLAYLAANLDV
ERYGEDAAEFDATQSRPRHLAFGHGPHTCLGAALARLEMEVALTTLFTEFPEVSLAEG
EAPRLESVFIHAPAALPIRLGPRRTAA

>CYP154G1   Thermobifida fusca GenEMBL NZ_AAAQ01000029a 
MLDTERGLTEADIHALAEHGPVVRLSVMGLDVWAVTGYEELRTL
MADPEVKRGVEHWTAVAQGKVPAEHPLVKLVSMGSMLSKNPPEHTRLRRLVQHAFTTR
RVEGLRPVVQELTRACLDRIDASQPFDINAALSHPVPVGVIGRLLGIPETDQPALDSL
VTRLLSGTDATVHEELYAYVAAMVAARREQPDDGLISALLHVHDDDGSTLSEEDLMWT
VVLLVDAGFETTVGQISNSVRLLLEHPDQLALVTSGEVPWERAVEECLRHTASVVMLP
FCFPTREKELGGYTIGAGEPVMMVYGAANRDSRVHAAPKVFDVTRSDSRHITFGHGPH
HCLGAPLARLELNVVLPELFARFPKLALAERDIPRVKSLFVNRPSELWVTAGMG

>CYP154H1   Thermobifida fusca GenEMBL NZ_AAAQ01000035b 
MMASPTDNPIVLDPYVSDLEGERERLYEAGPIAWVELPGGVRTW
SVTHHQAARELLTDSRLSKNMAHWGAYNRGEISPTWPLLSVIPPTPTNLLGTDGAEHK
RLRTLTAQAFTPRRVEKLRPRIREITEELLDALEERANEPQDLKSEFSFKLPMRVIGE
LYGVEEAAHGQLRSLYDKFFSSVTPPEEFLATREALVQFYTELMERKKANPSDDLTTA
LLQANENGDRMTDEEVLGTLQIVVAAGHETTVNLLTNTVRALLRFPDQLELLRTGKAT
WEAAIEESLRWDPPTTNFIFRFATEDIEYGGVTIAKGDSVMISYGAIGRDRGQHGDNP
EVFDVTRKTSSRHISFGYGPHVCPGAPLARLEAQVALPMLFERYPDMKLAVDDSELVP
NPSVIVNSLKEFPVILRP

>CYP154J1   Streptomyces carzinostaticus subsp. Neocarzinostaticus GenEMBL AY117439 
MCPYRLDPEGADTHGETARLREQGPIARVELQDGVLAWSVHDYA
VAKQIMADERFSKNPRKNWPAYINGEISNGWPLITWVAMDTMATQDGADHARLRKLLL
KAFTERRVESMRPHIEKTVKELLDNMAAKADDEIVDIKEMFHAELPTRLMCDLFGVPE
ERRAEVLAGGHKNIDTRISSEAAEANLGQWQEAISDLVEYKRHHPGDDLTSALIEARD
EGSRLSDSELIGTLHLLLGAGSETLVNALAHSSLALLVDADLRKKVTSGEIPWVNVWE
ETLRVESPVAHLPFRYATEDFEIGGVKISKGDPLLVDFAGIGRDPAVHSDAPDEFDAL
RPDKTHLSFGHGVHYCLGARLAKHAWMIGIPALFERFPDMELAVRRDELKGQGSFVVN
GHASLPVHLKGRAAALAR

>CYP154K1   Streptomyces rochei NC_004808 complement(144081..145325)
MLRQEAPYVIDSAGRDLPGEAARLRERGPVVRVVLPGGVSAWAV
TDLDLIKQLLTDSRASKDAYRHWPAWAGGEVDESWQMSMWVSVRNMLTAYGEEHARLR
RLVAGAFTARRTADLRPRVERITARLLDGLAAVPPGAAVDVRNEFARPLSVLVMGETL
GLPEDLHADLQRMVDVLFKTTAEPEEARANQYELYALLTELVAARRSAPGTDLTSELI
AARDEDGGEGLSEKELVDTLLLLIGAGTETTVNLIDQAVHGLITHPAQLALVLGGEAT
WDSVIDETLRHQPVVANVPFRFAVEDIEVGGVTIPKGDPILLSLAAAARCPHRHGADA
DQFDVARPSRRDHVPFGYGVHHCVGRPLARLEVSIALESLFARYPRMAAAVPEAELAV
RESFISSGHVALPVVLVPGAAA

>CYP155A1 AL158061.1 Streptomyces coelicolor cosmid 6D11 
DPGDHVVEPGGRRGRTAGVGGGHVVQDGRVSARKADRGRAGPAC
PVDRAADGTWRVHDFAVARALLRGPGTVQAGLGIETVEKLPPRVRRPVLYRDGPEHRE
HRRQTARYFTPRRVDEHYREPMVRIAEEQLAVLRSAGEAPLSDLAFGLAVGVVSEVVG
LRYSRPGIRRRLERFFPEEFGEPGLTSVRGLYWLVRQNTNWLRIHLADVRPAVRAHRR
REHDDLISHLIAEGCSDVEILGECLTFAAAGMVTTREFVCLAAWHLFSDAELLGHYRS
ADETGRLAVLQELLRLEPVIGSLRRRATGPVELSCRDGPVTVRPGEYVEVHLDDANAD
PKAVGEEPLLVRPERAGAVGAGLSFGDGPHRCPGAHIALLETDVFLSRLFALDGVRMS
GGPRVAFQEAIDGYEIRDLTVALPRAGRG

>CYP155B1   Deinococcus radiodurans NC_001264 192795..193784 
MPSFLSFRSSAMTAHDAQPEPARCPFTGQAAPTETITRRHVPPQ
GDLAQPVETYARARDLLKSEQAQQAGFLADMVSRVPGSQHPPVLYLEGEEHTEMRRAT
AKYFTPTQVNTYQPDIARLADELIGKLARRGEAKLDDLSLELAVRVAAGVVGLTNSRL
PGMDRRIERFIPSGVDAEPGVKLEGASPLENARQAANMALFYALDVKPAIEARRKAPQ
DDLISYLLSRGYNDQDILTECVTYGTAGMITTREFISVAAWHLLKNPELRAAYVHGTE
KERHAVLHEILRLEPVVGTLYRRA
GTGDDCGRRSHPAGSVFALDIGQANLDPAVMGEGAEQLCPMRELPRGVQAQGLSFG
DGHHRCPGAFLAIKETDVFLRRLLIWNDLHVVSEPRVTYNEVIKGYELRGFRVRLGGARA*

>CYP155B2P   Deinococcus radiodurans GenEMBL NC_000959 73..384 
SGSTDAEILPYVVEAEPSSPVVHLDISQ
ANRDESVFTQAQQFCPHRKNVRQHLSFGKGEHACLGQSLVYTICRVMAHALELLSAPAGQ
RTDQVSQ*

>CYP155C1    Brevibacterium linens strain ATCC 9175 AF139916
MNSVSMRKAVGTHDETEPRVGHDGTMWRIRSYEAATTVLRARHQ
TTQAGFTAEKIPRGYFRQHPILISDGDDHDVQRREVARYFAPAVVSAKYGDFINKRAQ
ALVDSALANGRLRLDEAALNYSVEVTAEIVGLTDSPIDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWIQAAVNGLVPIGRFYISDVRPAIRARRDRRRDDVLSHLLSAGYSTADIL
VECVTYGTAGMVTTREFITMACWHLLTNDELGRRYTEASQPTRLEILEEIIRLDPVVG
HLYRRAQADIEVSDNGCPYTIPEGDLIDVCVRQTNTDPQAMGAAPETVIPGRDLRRGS
AATGLSFSDGAHTCPGQPLALYETDALLHKVLATRPRILREPTISWDNVIEGYRLRGL
DLSLMTRSRPVTTRMTT

>CYP155C2    Brevibacterium linens strain ATCC 9174 (JGI genome project)
MNSAGMRKAVGAHDETEPRVEHDGAMWRIRSYEAATTVLRARHRTTQAGFTAEKIPRGYFRKHPILISDGDEHDSQRKEV
ARYFAPAVVSAKYGEFINERAQALVDRAVANGGLRLDEAALNYSVEVTAEIVGLTESSTDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWAQAAVNGLLPIGRFYVHDVQPAIRSRRSRRRDDVLSHLLSAGYSTADILVECMTYGTAGMVTTREFITMAC
WHLLTDEELGRRYTESSQPTRLKILEEIIRLDPVVGHLYRRAQADIEVSDNGCPHTISAGDLIDVCVRQTNTDPHAMGTA
PETIIPGRDLGRGTAATGLSFSDGAHACPGQPLALYETDALVHKLLTIGPRILRKPEISWDNLIEGYRLRGMDLSLMERS
RPAATREPI

>CYP156A1 AL353832 Streptomyces coelicolor cosmid E6 
MTLPSTETAPTGEPGRIALYAPEFAADPHAAYRSMRRTHGPLVP
VDLAPGVPATLVIGYYQARRILNDPLRFPADPRAWEKLIPATCPVRPMMEWRPNALRS
GGAEHTRYRSANTHAIDQVDQHGLRALVEQVASDAIEGFRTAGSADLLTQYSFPIAFR
VLSALLGCPDEIGQRIADGMAKIFDTTNADQGNLILAQAVSDLVTLRRTHPGDDITSR
LALHPVRLTDEEMSHQLVTLYGAGIEPMTNLISNTILKILTDEEFSADLHAGLSTVRD
ALDAVLYTDPPMANYCISYPPYPVDVEGVLLPADQPVVISMAAANNDPALTEGVPAGQ
HGGNRAHLAWSTGPHTCPARSHAYLIAETAVTHLLDALPETDLARPAAELVWRPGPFH
RALESLPVTFPAAQSAAH

>CYP156B1 Streptomyces coelicolor cosmid IF3 gene AL590982.1 10933-12276
MDATTPAVPPPGCPAHADARIPLYGPDFAADPHAYYDYARSYGP
SAPVELAPGVDASLVTDYATALRLLQDNGTFRKDARRWKAFNEGLIPADSPVVPLLAY
RPNAMFSDGAEHLRLRQAITDAMARIDTARLARSTEQISDYLISQFGSRGSADLMADY
AKQLPLFVFNELFGCPADIGDRILFGISGMFDGVNAERAAEVLFGAVGELVALKRSRP
GEDVTSWLMQHETRMTDEEMVYQLSLILGAGADPLRNLIGNTLHRILIHDEYARQGGL
IDEAMEDTLWENPPVPNLAPHYPAADVEFAGQKFEAGELIMVSFAAANNSPSLAAARQ
SGSNRSHLAWSAGPHACPSKDPARQITMAAVENLLNRIPDIAAAVPEDSLTWRPGPFT
RGLTALPARFTPLPAPDRTPAPAQAPAGERAEQSGTARKAAGTGRWSQFLNWLTR

>CYP157A1 AL158061 Streptomyces coelicolor cosmid 6D11 
MSTDAHDVPGAVPLGGPRFQTDPALLYRQMRREHGAVTPVVLDG
DVPAWLVLGYRELHQVTGDPVLFSRDSDLWNQWENIPDDWPLLPMIGRRQPSILYTVG
ERHRERAAMISDALEAVDPHLLRGHAERFADELVDRLCAKGEADLVGDYAMLLPVRVL
ARLYGFPDEQGPALVTALNDMIDGRERALAGQTHLGTSMARLLADRKAAPADDVASRM
LADESGFTEEEVAQDLMVMMAAGHQPTADWIGNSLRLMLTDDRFAASLFGGRNSVAEA
MNEVLWEDTPTQNVAGRWAARDTQLGGRRIRAGDLVLLGLQGANSDPQVRTDGSALTG
GNNAHFSFGHGEHRCPFPAQEVAEVIARTGIEVVLDRLPDIDLAVPAGSLTRRPSPWL
RGLTELPVRFTPTTALGGTSA

>CYP157A2 SAV3881 AP005036 Streptomyces avermitilis
MTPAPAPAPVPLSGPRFQTDPAALYREMRREHGSVAPVLLDGDI
PAWLVLGYRELHQVTGDPVLFSRDSELWNQWPNIPADWPLLPMIGHKQPSILYTVGER
HRERAAMISDALEAVDPFELRSLTEKFADELIDAVCAKGETDLVADYAALLPVRVLAL
LYGFAEEQGPGLVTALNDMIDGRDRAIAGQTHLATSMAQLLADRKAEPANDVVSRMLA
DSGGFTDEEIAQDLMVMMAAGHQPTADWIGNSLRLMLTDERFAASLFGGRNSVAEAMN
EVLWEDTPTQNVAGRWASRDTQLGGRRVRAGDLLLLGLQGANNDPQVRIDGAALTGGN
NAHFSFGHGEHRCPFPAQEIAEVIARTGIEVVLDRLPDIDLALPAGSLARRPSPWLRG
LTELPVKFTPIPALGGSPA

>CYP157A3   Thermobifida fusca GenEMBL NZ_AAAQ01000035a 
MGPAVHRGARRSRPRRRPPTRRLLVLHRPAGGARHSLRRRPQQL
RVLLHPGPDPRGTRPGPLSPPPGMRRPGTRVRQTGAGHPGPTCDDDHRGGGRPMNAQR
GIPSSHQNAFRLYGPQFQNKPAELYRQMRTDYGPVAPVLLDGDIPAWLVIGYREVTHV
LNHPETFARSSRRWNAWDLVPENWPLYPMVTRTPNILYSEGEEHRRRATAISDALSGA
DQHEVRQYAVQAADRLIDGFCAASRADLRADYASRLPAIVLGRLYGLDQKHAEVLAEA
MTTMIDSGPDAVKAQQFLLQTMGTLVAERRKQPGPDVVSRLVHHPAKLRDEELIPDLV
VILGGGHQPTTEWLGNTLRLMLTDDRFAASLTGARSSVREALNEVLWEDTPTQIYLGR
YAAHDVELGGQLIRRGDLVLLGLAGANSDPQINPGPECRMSQGNQAYLSFSHGEHRCP
YPAPELAEIIVTAGIEVLLDRLPDVELAVPVDELRWRPSPWMRGLVALPVVFTPVPPI
GGQ

>CYP157B1 AL132991 Streptomyces coelicolor cosmid F55 
MTDIDPSPHPVAAPGCPVHPDAVPLAGLEYQQTPSELYRGLRAE
HGAVAPVLLDGGIPAWLVLGYPEVSYVTSHDELFARDSRRWNQWGSIPPDWPLLPYVG
HQPSVLFTEGEEHRRRAGVITQALAGIDQFELARDCRHLADRLIAAFAGSGRAELMSG
YAHPLPMRAAVRMCGMPHTGVETRQLVEDLRISLDAAEGDDPVAAYTRVGERIHQLVR
HKRERPGPDVTSRMLTHPAGLTDEEIVQDLISVIAAAQQPTANWIGNTLRLLLTDERF
ALNVSGGRLSVGEALNEVLWLDTPTQNFIGRWAVNDTQLGGRHIRAGDCLVLGFAAAN
TDPQLWPEAHVGAENSAHLSFSNGEHRCPYPAPLLADVVARTAVETLLERLPDLVLAL
EPGELTWRPSIWMRGLTALPALFTPVVA

>CYP157B2   Streptomyces hygroscopicus subsp. Yingchengensis AY260760 
MGSATSELPSQRTPLTAAAETGLKIVVVGGFGVGKTTLVRSVSE
IRPLNTEELMTQAGQGIDETAGVERKTTTTVAFDFGRISLNDRMVLYLFGAPGQERFW
FLWDRLFAGTLGAVVLVDTRRMEDCWYAIDRLEHHGTPFVVAVNRFDGDEKRFSLDEV
RQALALGEHVPMIECDARVRASGKEVLIALVDHLYTRALAKESTACSDTTGFPSTDAP

PPGCPAHGSAVPLAGLEYQQTPSQLYRTLRREHGAVAPVLLDGGIPAWLVLGYPEVCY
VTAHDELFARDSRRWNQWEHIPPDWPLLPYVGYQPSVLFTEGAEHQRRAGVITQALEG
VDQFELARECQLIAARLISSFSGSGRAELMSMYAHALPARGVLWMCGMPAEDADTERL
VDDLRISLDAGEGDDPVAAYTRVGERIMRLVKEKRERPGPDVTSRMILHPAGLGDEEI
VQDLISVIAAAQQPTANWICNTLRLLLTDERFAVNVAGGRVSVGEALNEVLWLDTPTQ
NFIGRWAVRDTQLGGRHIREGDCLVLGLAAANTDPQIWPEPHAGSGNSAHLSFSNGEH
RCPYPAPLLADVMARTAVETLLEHLPDLVLAVEPEELTWRPSIWMRGLTSLPVEFTPAMN

>CYP157C1 AL132648 Streptomyces coelicolor cosmid I41 
MTPESHSPTGTGEPLLEPPPGCPAHGLGPGGLHRLHEAEDLEEL
YEKLREQHGPVAPALLHDDVPMWVVLGHAENLHMVSTPSQFCRDSRIWTPLNEGMVKP
DHPLMPHIAWQPICSHAEGDEHKRLRGAVTSAMSDLDYRELRRHIKRYTQRVVNRFCE
EGRADLVSQFAEHLPMGVMCHLLGMPEEYNDRLVEAARDTLKGTETAIASHAYVMEAL
GRLTATRRADPADDIAGRLVTHPAGLTDDEVREHLRVVLLAAYEATVNLIGNVMRVVL
TDPGFRAQLSGGQMTVPQAVEQSLWDEPPFSTVFAYFAKQETELGGQRIRAGDGLLLG
IAPGNVDPRIRPDLDASMMGNRAHLAFGGGPHECPGQDIGRAIADAGIDALLMRLPDL
QLDCDEDDLRWRSSIASRHLVELPVRFEPRAQQDIMQQPSHAPTPERHAPWHVGLPKP
ERRAQPPLPAQPPQPVSVTAAEPQQAPGAGQPRPRGAWQRFLLWWRGY

>CYP157C2 SAV6706 AP005047 Streptomyces avermitilis
MTPEPHPSTGTDDPTFGPPPGCPAHDPGLGGVRRLYGPEAEDLG
DLYEKLRAEHGAVAPVLLHNDVPMWVVLGHTENLHMVRSPSQYTRDSRVWTPVLDGTA
GPDHPLMPHIAWQPICSHAEGDEHLRLRGAVSGAISTIDHRGIRRYINRSSQALVNRF
CEEGRADLVGQFAEHLPMAVMCEILGMPDEYNDRMVQAARDMLKGTETAIASNAYVMD
ALMRLTARRRAHPEGDFTSHLINHPAQLSDDEVGQHLRLVLIAAYEATTNLLANVLRM
VLTDPRFRAQLNGGQMTVPEAVEQSLWDEPPFSTVLGYFAKQETELGGQLIRKGDGLL
LGIAPGNVDPHVRPDLSANMQGNRSHLAFGGGPHECPGQDVGRAIADVGVDALLMRLP
DVQLDCAEDELRWTASISSRHLVELPVRFAPKEPQDVSQRPSLRPLPQPVPSRPVRTQ
QPQATTPPPAPPAPPAAAPERGPGAWQRFLRWWRGY

>CYP157C3   Streptomyces griseus GenEMBL AB044803 3754..5328
MTTPFHHEPGTVPPPQCPAHNLDIGPGGLRRLHGPEAENNPAGL
YDKLRAEHGTVAPILLHGDVPAWLVLGHSENLHVTRTPSQFSRDSRRWRALQDGSVAP
DHPLAPIFTWQPICVFADGPKHERQRGAVTDSMERIDTRGVRRHINRFSNRLVNDFCE
KGTADLVGQFAEHLPMMVVCAIFGMPEEYDERLVQAARDMTRGTETAVASNAHIVSVL
TRLVERRRAEPSPDLASWLVEHPATMTDTEVIEHLRLIMIAAYESTANLIANVLRMVL
IDPRFRARLSGGHMTVPEAVEQTLWDEPPFTAVFGRWAVGDTELGGQQIKAGDALLVG
IAPANTDPTVRPDLGADMGGNRAHLAFSGGPHECPGQDIGRAIADVGVDALLMRLPDL
ELGVGESELHWVGNIMSRHLVELPVKFAPGPQQKLDADPLTVMARLLAPPTPGRSPPR
PGRSPSPATRGPWRRAHAPGAAPTAEPDPAPAAPPAPEPAAAPEPAPVATIPQQRRPA
APARFWQAVTRWWSGY

>CYP158A1 AL353864 Streptomyces coelicolor cosmid 8F11 
MTQETTTLTGQSPPPVRDWPALDLDGPEFDPVLAELMREGPLTR
VRLPHGEGWAWLATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQP
DHNRLRRAVAGAFTVGATKRLRPRAQEILDGLVDGILAEGPPADLVERVLEPFPIAVV
SEVMGVPAADRERVHSWTRQIISTSGGAEAAERAKRGLYGWITETVRARAGSEGGDVY
SMLGAAVGRGEVGETEAVGLAGPLQIGGEAVTHNVGQMLYLLLTRRELMARMRERPGA
RGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDP
DRIDLDRDPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWR
RKTMIRGPRTLPCTW

>CYP158A2    Streptomyces coelicolor AL939108.1 CDS 76346-77560
MTEETISQAVPPVRDWPAVDLPGSDFDPVLTELMREGPVTRISL
PNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFIPARGAVGFLDPPDHT
RLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICEL
MGVPATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLL
GAAVGRDEITLSEAVGLAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSEPEIRPR
AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRI
DFERSPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGA
LIRGPEALPVTW

>CYP158A3 SAV7130 AP005049 Streptomyces avermitilis
MTEKTITEALPPVRHWPALNLTGVEFDPVLSQLMSEGPVSRIQLPNGEGW
AWLVTRYDDVRMVANDPRFSRAAVMGRQVTRLAPHFIPTAGAVGFLDPPD
HTRLRRSVAAAFTARGVERVREKSRRMLDELIDELLRGGPPADLVETVLS
PFPIAVVCELMGVPAADRHSMHTWTQLILSSAHGAEVSEKARNDMGAHFE
RLIGERRGSTGEDVTSLLGAAVGSGEITLDEAVGLAVLIQIGGEAVTNNS
GQLFYILLTRPDLAERLRAEPKIRPQGIDELLRYIPHRNAVGLSRIATED
IEIRGVRIREGDTVYVSYLAANRDPDVFPDPERIDLTRSPNPHVSFGFGP
HYCVGGMLARLESELLVEALLDRVPGLRLAVPPGLVPFKKGALIRGPEAL
PVTW

>CYP158B1   Saccharopolyspora erythraea GenEMBL AY078067 4211..5416
MTDRCPARMYDPADLPGMTFDPVFLELLRDEPVARIRMRYGEGE
AWLLTRYEDVKFVTSDPRFSRKIMGRPFPKMTKHHIPMDRAISFSDPPEHARVRRVVA
RDFSPGSIERLRPTGREIMHRYLDELVASGPPADLVRHVTSPFPMAVLGELMGIPESD
RQWLIDCSSQVLSMAPDQAAVDRINGIKAEVAEYFLALVESRRADPRDDVVSTVAAAR
ERGDLDDEEVGAMTVLLALNGWHAVRNNSTNMVYVLLTDPELRSRLKADLALVPTAVE
ELLRYIPHKRGIGQPRIATEDVDIRGVRISKGDVVYVSYIAANWDEEVYPEPDRVDLD
RPEVPHLAFGHGPHYCMGPMLARMESQVLLSSLLTRLPDLALAVPPEQVAWQPNALIR
GPVELPVTW

>CYP159A1 AL132991 Streptomyces coelicolor cosmid F55 
MSTAQQVPDILSPEFAANPYPAYRTMRDSAPLIRHEATQSWIVS
RYEDVERVFKDRAGQFTTENYDWQIEPVHGRTILQLSGREHAVRRALVAPAFRGADLQ
ERFLPVIERNSRELIDAFRHTGRADLVADYATRFPVNVIADMLGLDKADHDRFHGWYT
SVIAFLGNLSGDQEVAAAGARTRTEFAEYMIPVIRERRENPGDDLLSTLCAAEVDGVR
MSDEDIKAFCSLLLAAGGETTDKAIAGIFANLLAHPEQLAAVREDRSLIPRAFAETLR
YTPPVHMIMRQTATDVTLSGGTIPAGATVTCLIGAANRDETRYRDPDRFDIMRDDLTT
TTAFSAAADHLAFALGRHFCVGALLAKAEVEIGVGQLLDALPGLRTEDGFEVVERGVF
TRGPQSLPVRFTPAA

>CYP159A2   Streptomyces hygroscopicus Yingchengensis GenEMBL AY260760 983..2209
MSAAHHLPDILSPEFAANPYPAYAVMREKEPLIWHEATQSYIIS
RYEDVERVFKDKKAEFTTDNYNWQLEPVHGKTILQLSGREHAVRRALVAPAFRGSDLE
QKFLPVIERNSRELIDAFRHTGSADIVNDYATRFPVNVIADMLGLDKADHARFHGWYT
AVIAFLGNLSGDPEVAAAGERTRVEFAEYMLPVIRERRANPGDDLLSTLCAAEVDGVR
MSDEDIKAFCSLLLAAGGETTDKAIAGILANLLSHPDQLAAVRADRSLIPAAFAETLR
YTPPVQMIMRQSATDVEVTGGTIPAGATVTCLIGAANRDERRYRDPDRFDIFRDDLAT
TSAFSAAAGHLAFALGRHFCVGALLAKAEVEVGLNQLLDAMPDLRLADGHDLVEQGVF
TRGPKTLPVRFTPVTA

>CYP160A1 AF127374 Streptomyces lavendulae LinA homolog 
MTSAAPPAFPFPPGPGGTVPPEYARLLTDDPVAEVRLADGSRIW
LVTRHEDVRTVLTDGRFSRHRAAMLPGSGFGRSQGSGIVDLDPPEHGRLRGPVVAAFG
ASRTARFAPRIEAAAEAALDRLPAGSGTVDLVAAYTAPFAGRVTAEFLGLPGDRWQDV
TSDVELLLLPRGATEQALKEARGRLGQVLDELLAARRAEPGDSVTDTLLDAEELTDDD
RRLLLHGLIISGFITIRDLLARHLFGVLSSPGLAARLREDPSVLPSAVQELLRYYPSS
NDGLLRVATEDVVLSGRRVAAGDAVLPLVSAASRDPEVFADPHVLDIERVADRGIAFG
AGQHACPATGLAVTELTVGIGRLLAAFPRIALAVPPEEVEHSSELLPLGVRSLPVVPG
PRN

>CYP161A1 AF263912 Streptomyces noursei ATCC 11455 nyst gene="nysL"
MSTPTAPPSLKAEVPPVLRLSPLLRELQSRAPVCKVRTPAGDEG
WLVTRHTELKQLLHDDRLARAHADPANAPRYVHNPFLDLLVVDDFDLARTLHAEMRSL
FTPQFSARRVMDLTPRVEALAEGVLAHFVAQGPPADLHNDFSLPFSLSVLCALIGVPA
EEQGKLIAALTKLGELDDPARVQEGQDELFGLLSGLARRKRITPEDDVISRLCLKVPS
DERIGPIASGLLFAGLDSVASHIDLGTVLFIQHPDQLAAALADEKLMRGAVEEILRSA
KAGGSVLPRYATADVPIGDVTIRAGDLVLLDFTLVNFDRTVFDEPELFDIRRAPNPHL
TFGHGMWHCIGAPLARVNLRTAYTLLFTRLPGLRLVRPVEELRVLSGQLSAGLTELPV
TW

>CYP161A2   Streptomyces natalensis GenEMBL AJ278573 81418..82611
MTAASHDLPCLNLEPPKMLKLSPLLRALQDRGPIHRVRTPAGDE
AWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLDLLISDADAESGRRQHAETR
RLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGDLHGELTVPFALTVLCEVIGV
PPQRRAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLNDGE
LTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPDVMARAVEEVLR
TARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAARTPN
PHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPVEQLRLKEGQLSGGFAELRVVW

>CYP161A3   Streptomyces nodosus GenEMBL AF357202 56829..58019
MVNPTPPPSLEDAAPSVLRLSPLLRELQMRAPVTKIRTPAGDEG
WLVTRHAELKQLLHDERLARAHADPANAPRYVKSPLMDLLIMDDVEAARAAHAELRTL
LTPQFSARRVLNMMPMVEGIAEQILNGFAAQEQPADLRGNFSLPYSLTVLCALIGIPL
QEQGQLLAVLGEMATLNDAESVARSQAKLFGLLTDLAGRKRAEPGDDVISRLCETVPE
DERIGPIAASLLFAGLDSVATHVDLGVVLFTQYPDQLKEALADEKLMRSGVEEILRAA
KAGGSGAALPRYATDDIEIADVTIRTGDLVLLDFTLVNFDEAVFDDADLFDIRRSPNE
HLTFGHGMWHCIGAPLARMMLKTAYTQLFTRLPGLKLASSVEELQVTSGQLNGGLTEL
PVTW

>CYP162A1 AJ250199 Streptomyces tendae nikkomycin gene="nikQ"
MRVDLSDPLLYRDSDPEPVWSRLRAEHPVYRNERANGEHFWAVM
THGLCTDMLTDPRVFSSQNGMRLDSDPQVLAAAAGKMLNITDPPRHDKIRKVVSSAFT
PRMVSRLEATMRETAAKAIDEALAAGECEFTRVAQKLPVSVICDMLGVAPADWDFMVE
RTRFAWSSTALDEAEEARKVRAHTEILLHFQDLAAERRREPKDDLMSALVCGEIDGAP
LTDQEILYNCDALVSGGNETTRHATVGGLLALIDNPDQWHRLRDEPALMPSAIQEIVR
YTSPVMHALRTATEDVEFGGERISAGDHVVAWLPSANRDEKVFDDPDRFDIEREPNRH
LGFIQGNHYCIGSSLAKLELTVMFEELLARVEVAELAGQVRRLRSNLLWGFDSLPVKF
VPRA

>CYP163A1 AF170880 Streptomyces spheroides novobiocin gene="novI"
MSTRPTVSPSELEQIDLASPVLHAEYELDEIFRHLRADEPVYWQ
QPRNEQPGFWVISRHADVNEVYKDKEHFTTEHGNALATLLTGGDSASGAMLAVTDGVR
HHQVRNVLSRGFSARMLDLIAHTLQETVDGLLLAALERGECDAAQDIAADVPLGAICD
LLEIPHADRKYLLGLTSHAWSTDYADEPPEESWVAKNEILLYFSKLLKERRGGVREDM
VSLLANCRIDGDPLKAAEQMANCYGLMIGGDETGRHAITGTILALIQNPDQWRALKNG
DVDLNTATEEALRWTVPSLHGGRKATGDVVINGRRINAGDVVSVWISSANRDETVFDA
PDEFNLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYS
SILHGMSSLPIRITG

>CYP163A2   Streptomyces roseochromogenes subsp. Oscitans AF329398 15196..16419
MSTRPTVSPDELEQIDLASPILHAEYELGEVFRYLRANRPMYWQ
QPRGEQPGFWVISRYADVNEVYKDKAHFTTEHGNALATLLTGGDSASGAMLAVTDGVR
HHQVRNLLSKGFSPQMLDLIANSLRETVDGLLLAALDRGECDAAQDIAANVPLGAICD
LLEIPQTDRKYLLGLTAHAWSTDYADETPEEGWVAKNEILLYFSKLLKERRGGDRDDM
VSLLANCRIDGHPLNAAEQVANCYGLMIGGDETGRHAITGTILALIENPDQWRALKNG
DVDLKTATEEALRWTVPSLHGGRKATGDVVINGQQIKAGDVVSVWISSANRDEAIFDA
ADEFKLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYS
SILHGMSSLPIRITV

>CYP163A3   Streptomyces antibioticus GenEMBL AF322256 22228..23478
MNPRPMLSPDVLEDIDLNDRQLHADYDLSEVWRYLRAERPFYYQ
TARGSQPGFWVVTRHADCTAVYKDKTNFTAERGNVLPTLLAGGDSASRTMLALTDGDR
HTQVRNLLMKAFSPKMLSNIGQSLRTTVDGLLRDAIEKGECDFARDVSGKVPLVAICD
LLAVPQEDREYLLSLTAHALSADEADATAEDNWTAKNEILLYFADLAESRRSSGHNDV
VSLLATSSIEGEPLSDGELMANCYGLMIGGDETGRHAITGGLRALIHHPDQWRMLRNG
EADLQTATEEVLRWTVPSLHGARTATADVVVNGKQQIRAGEIVSVWFASANRDEEVFR
DADRFDLNRTPNKHLTFAFGPHFCLGHYLARMEVEAILDGLRRMVDDIQQTGPEKLIY
SSILQGISSFPALLKPDRRVPPQT

>CYP164A1 AL007924 Mycobacterium leprae GenPept CAC31043
1 MRTCVPTRTC VYAFIEYLSH NRPMGTNPPS LVEAQMLLLR LIDPGTRADP FPVYRALIDY
 61 GPMQLPGMPL TVFSSFSDCD EALRHPLSAS DRLKATLAQQ AIAAGAEPRP FYASSFMFLD
121 PPDHTRLRKL VSKAFAPKVV QALEGDIAAL VDSLLDKGAA AGQFDVIADL AFPLAVAVIC
181 RLLGVPYEDA PEFGRVSALL VQSVDPFITI TGEPPEATEE RLRAGVWLRD YLEQLVKCRR
241 GTPGEDLISR LIELDESGDQ LTEEEIIATC GLLLVAGHET TVNLIANAVL AMLRNPSQWK
301 ALSSNPQRAP LVVEETLRYD PAIHLIGRVA AKDMTIGQTT LTEGDTMVLL LAAANRDPAV
361 YSRPDEFDPD RPSSRHLAFA VGSHFCLGAA LARLEATVTL SAISARFPQV QLAGELVYKP
421 NVAMRGMSAL PVQV

>CYP164A2   Mycobacterium smegmatis  MSMEG6272 TIGR 
MHNGWMSTAATAQEAQGLLLQLLDPATRADPYPIYDRIRRGGPLALPEAN
LAVFSSFSDCDDVLRHPSSCSDRTKSTIFQRQLAAETQPRPQGPASFLFL
DPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDGPEFNLIDNL
AYPLPVAVICRLLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDE
QMKAGMWLRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATC
NLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRASAVIEETMRYD
PPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD
RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR
NLTLRGMSTLSIAV

>CYP164A4   Mycobacterium vanbaalenii PYR-1 ZP_01206517.1, EAS24279.1 
MRLLHLHALHPRVSAPLVQGQGDAVRDAVHDPQRAVRHPPRRRHPRRHPRGPVRRAARARPRPVLRQGVA SAGVFDLHPFRLVHNKSMTTAAEPQSLLLQMLAPEVRADPYPVYAQILAHGPMQLPGNNLTVFSSYADCD EVLRHPDASSDRLKSTAAQRAIADGAEARPFGPPGFLFLDPPDHTRLRWLVSKAFVPKVVKALEPDIVTM VDGLLREAEAGATFEAIGGLAYPLPVAVICRLLGVPLEDEPQFSAASALLAQSLDPFISVTGSAGSGFEE RMQAARWLRGYLRELIARRRRDPGEDLMSGLIHVEESGDQLTEDEIVATCNLLLVAGHETTVNLIANAIL ALLRNDGQWAALAADPGRAAAVIEETLRHDPPVQLVGRIAGQDMTIGGERSDGGNVAGGVTVPKGDNILL LTAAAHRDPDHVDRPDEFDPDRPVIRHLGFGKGAHFCLGAPLARLEATLALTALTSRFPDAKLAAEPVYK PNVTLRGMSELSITLA

>CYP164A5P Mycobacterium leprae cosmid B1450 GenEMBL AL035159.1 
AVDALLCFLSPPGLAGPRFAVTDVEIGQHTVVAGQTVRLYLASANHDPQRFNCTDELEPTRPAPHTA

>CYP165A1 Y16952 Amycolatopsis mediterranei 
MFEESNALRGTEIHRRDRFAPGPELRSLMGEGTMSILQPPDSPG
GRTGWLATGHDEVRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMVTS
AFTVRRMQDFRPRIEQIVQASLDAIEAAGGPVDFVPRFAWSVATTVTCDFLGIPRDDQ
ADLSRALHASRSERSGKRRVAAGNKYWTYMTEIAARARRDPGDDMFGAVVRDHGDAIT
DAELLGVAAFVMGAGGDQVARFLAAGAWLMVEHPDQFALLREKPDTVPDWLNEVERYL
TSDEKTTPRIAQEDVRIGDQLVKAGDAVTCSLLAANRRKFPAPEDEFDITRERPVHVT
FGHGIHHCLGRPLAEMVFRAAIPALAQRFPKLRLAEPDREIKLGPPPFDVEALLLEW

>CYP165A2 AJ223999 Amycolatopsis orientalis 
MFAENNAVRGTEIHRREQFDPGPELRSLMAEGPMSILEADDPAE
GRTGWLATGYDEIRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMLTS
AFTVRRMQGFRPRIELIVEATLDDIEATGGPVDFVPRFAWPIATTVTCDFIGIPRDDQ
ADLSRALLASRSERTGKRRVAAGNKFWTYMSQVAAQARRDPGDNMFGAVVREHGDAIT
DAELLGVAAFIIGAAGDQVARFLAAGAWLIAEHPEQFAVLRDKPDTIPDWLNEVARYL
TSDEKTTPRIALEDVYIGDQLVKAGDAVTCSLLAANRRNFPAPEDQFDITRERPAHVT
FGHGIHHCLGRPLAEMVFRTAITALTRRFPTLRLAEPGREIKLGPPPFDVEVLLLDW

>CYP165A3    Amycolatopsis orientalis GenEMBL AF486630
MFEEKNALRGTEIHRRERFDPGPELRALMAEGRMSVMESEESPG
GRTGWLATGYEETRQVLGSDKFSAKLLFGGTAAGRIWPGFLNQYDPPEHTRLRRMVAS
AFTVRRMRDFRPRIEAVVKATLDDIEATGGPVDFVPRFAWPIATTVICDFLGIPRDDQ
AELSRVLHASRSERSGKRRVAAGNKYWTYMGQVAAKTRRDPGDDMFGAVVREHGDDIT
DAELLGVAAFVMGASGDQVARFLSAGAWLMVEHPEQFAVLRDDPDSVPDWLNEVARYL
TSDEKTTPRIALEDVRIGDQLVKKGDAVTCSLLASNRHRFPDPEDRFDITREKPSHVT
FGHGIHHCLGRPLAEMVFRTAIPALAHRFPTLRLAEPDREIKLGPPPFDVEALLLDW

>CYP165A4   Streptomcyes toyocaensis AF039028 complement(11438..12613)
MFEEINVVRASQLHRRDRFDPVPELHSLMKEGGLTVLGTEDSTE
GRTAWLATGIDEVRQVLGSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVP
AFSHRRMQKFRPRVEQIVQDSLDTIESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQ
ADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAIT
DAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVPEWLDETMRYL
TTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPNYPSAEDEFDITREKAEHLA
FGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPPFDVEALLLDW

>CYP165A5   Actinomadura sp. ATCC 39727 GenEMBL AJ561198 complement(23387..24568)
MEVFEELNVVLPGELHWRDRFDPVPQLRSFMAEGPMTELGAEEG
PGGRTAWLATGFDEVRQVLGSDKFSSRLLYGGTAAGIVFPGFITQYDPPEHTRLRRVV
SPAFTVRRMERFRPQVDQVVEDCLDAIESIGGPLDFVPHFGWSIATTATCDFLGIPRD
DQAELSRSLHASRSQRAASRRGAAGNKFMTYMGQVVARTRRDPGDDMLSVVVREHGDE
ITDAELTGLAAFVMGAGGDQVARFLAAGAWLMAEVPEQFALLRDKPDVVPDWLEEMVR
YLTIDEKLTPRIALEDVRIGDRIVKAGDTVTCSLLGANRRHFPGPDDQFDLTRDRAPN
VAFGHGIHHCLGRPLAELIFRSAIPALARRFPALRLAEPEQEIRLGPPPFDVKALLLDW

>CYP165B1 Y16952 Amycolatopsis mediterranei gene="oxyB"
MNDDDPRPLHIRRQGLDPADELLAAGSLTRVTIGSGADAETHWM
ATAHALVRQVMGDHQRFSTRRRWDPRDEIGGTGTFRPRELVGNLMDYDPPEHTRLRQK
LTPGFTLRKMQRLQPYIEQIVNERLDEMARAGSPADLVAFVADKVPGAVLCELIGVPR
DDRATFMQLCHAHLDASRSQKRRAAAGEAFSRYLLAMIARERKDPGEGLIGAVVAEYG
DEATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIDALRGGEQPAQRAVDEL
IRYLTVPYGPTPRIAKQDVTVGDQVIKAGESVICSLPAANRDPALVPDADRLDVTRDP
VPHVAFGHGIHHCLGAALARLELRTVFTALWRRFPDLRLADPAQETKFRLTTPAYGLT
ELMVAW

>CYP165B2 AJ223999 Amycolatopsis orientalis 
MVAQELSQSGDDDPRPLHIRRQDLDPADELLAAGALTRVTVGSG
ADAETSWMATTHGAVRQVMGDHKSFSTRRRWHQRDEIGGTGIFRPRELVGNLMDYDPP
EHTRLRQKLTPGFTLRKMQRMQPYIEQIVADRLDAMEQAGSPADLIEFVADEVPGAVL
CELIGVPRDDRAMFMQLCHGHLDASRSQKRRAAAGEAFSRYLLAMIARERKDPGEGLI
GAVIAEYGDEATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIAAFQGDEQS
AQRAVDELIRYLTVPYAPTPRIAMQDVIVASQMIKKGESVICSLPAANRDPALVPDPN
RLDVTREPVPHVAFGHGVHHCLGAALSRLELRTVYTALWQRFPTLRLADPAKETNFRL
TTPAYGVTSLLVAW

>CYP165B3    Amycolatopsis orientalis GenEMBL AF486630; AAL90878.1
MSEDDPRPLHIRRQGLDPADELLAAGALTRVTIGSGADAETHWM
ATAHAVVRQVMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRK
LTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPR
DDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYG
DDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQRAVDEL
IRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREP
IPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLT
ELMVAW

>CYP165B4   Streptomcyes toyocaensis U82965 AF039028 complement(9077..10273)
MSGDDRPPIHTLRQGFDPADELRAAGELTRVRLGSGADAEHTWL
ATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELVGNLMDYDPPEHTRLRRL
LAPGFTHRKIRRMAPYIEQIVTERLDEMEREGSPADLIELFADEVPGPVLCELLGVPR
DDRAMFLQLCHRHLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHG
DTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPAAERAVDEL
IRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREA
VPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATEFRLSTPAYGIS
RLMVTW

>CYP165B5   Streptomyces lavendulae GenEMBL AF386507 42222..43493
MPQQAQRQAPQQQPRAQQAYPELLYTRRTRFDPADDLRAAPPLS
RYVIGPNESDEWVWLATGYTEVRRILGDHTNFSTRRRWGAEGPNWRPPELVGHLMDYD
PPEHTRLRQMLTPEFTVRRLRRLEPDITAIIEEHLDTVEATGPGADLMPLFAQPVPGE
VLCELIGVPRDDRPEFLRHCHRHLDFSRSRKVRAADGAAFSRYLVSMVARQRKDPDDG
FIGALVREHGDDFTDEEMRGVCVLLILAGIDNIEGMIGLGVLAMLENPDQLPLLLGER
DSTGGPGAGKGDGGRLASDRALDELIRYMSVANAPTPRTAVNDVRIGDQLIKAGETVI
CSLTMANRDPALTDGPDRLDLAREPVAHVAFGHGVHHCLGAALARTELRIAYKALWRR
FPELRLAVPVEEVRFYNRALAHGVHRLPVAW

>CYP165B6   Actinomadura sp. ATCC 39727 GenEMBL AJ561198 complement(21025..22221)
MSGDGARPLHTRRQDLDPADELRAAGTLTRITIGSGADAETTWL
ATGYTVVRQVLGDHRRFSTRRRWNERDEIGGRGNFRPRELVGNLMDYDPPEHTRLRQK
LTPGFTLRRIRRLKPYIEQIVTERLDALERAGPPADLVELVADEVPGAVLCELIGVPR
DDRAMFMQLCHGHLDASRSQKRRAAAGAAFSRYLLAMIARERKDPGEGLLGAVLAEYG
DTATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIAALQGDDQSADRAVDEL
IRYLTVPYAPTPRVAMEDVTIGGQVIKEGETVSCSLPMANRDPALLPDAGRLDVRREP
VPHVAFGHGVHHCLGAALARLELRTVYTALWRRFPTLRLADPDREPSFRLTTPAYGLT
SLMVAW

>CYP165C1 Y16952 Amycolatopsis mediterranei gene="oxyC"
MGHDIGQLAPLLPEPANFQLRTNCDPHADNFDLRAHGPLVRIAG
DSSAQLGREYVWQAHGYDVVRRILGDHENFTTRPQFTQAKSGAHVEAQFVGQISTYDP
PEHTRLRKMLTPEFTVRRIRRMEPAIQALVDDRLDRVAAEGPPADLQALFADPVGALA
LCELLGIPRDDQREFVRRIRRNTDLSRGLKARAADSAAFNRYLDNLIARQRRDADDGF
LGMIVREHGDTVTDEELKGLCTALILGGVETVAGMIGFGVLALLENPGQVPLLFAGPE
QADRVVNELLRYLSPVQAPNPSLAVKDVIIDGQLIKAGDYVLCSVLMANRDEALTPNP
NVFDANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQALWQRFPGLRLAVPIAEVKYR
SAFVDCPDRVPVTW

>CYP165C2 U84350 Amycolatopsis orientalis 
ISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLVDDRLDMLE
AEGSPADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAA
FNRYLDNLIARQRADPDDGLLGTIVREHGGNVTDEELRGLCTALILGGVETVAGMIGF
GVLALLQHPGQIPLLFEGPEKADRVVNELVRYLSPVQAPNPRLAIKDVVVDGQLIKAG
DYVLCSVLMANRDEALTPDPNVFDANRTAVSDVGFGHGIHYCVGAALARSMLRTAYQT
LWRRFPGLRLAVPVEEVKYRSAFVDCPDQVPVTW

>CYP165C3 AJ223998 Amycolatopsis orientalis cosmid PCZA361 gene 1 
MAHGIDQHGIDQHGIDQHGIDQHGIDQHGIDQHGIDQHSIDQHG
IDQHGMEQVAPLLQEPANFQMRTGCDPHEENFDLRAHGPLVRLVGDSSTQLGRDYVWQ
AHGYDVVRKILGDHENFTTRPQFTHAKSDAHVEAQFVGQISTYDPPEHTRLRKMLT
PEFTVRRIRRMEPAIQGLIDDRLDMVEAEGPPADLQGLFADPVGALALCELLGIPRDD
QREFVRRIRRNTDLSRGLKARAADSAAFNRYLDNLISRQRKDPDEGFLGMIVREHGDN
VTDEELKGLCTALILGGVETVAGMIGFGVLALLENPDQIQLLFAGPEKADRVVNELVR
YLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSVLMANRDEALTPNPNVLDANRAAVS
DVGFGHGIHYCVGAALARSMLRMAYQTLWQRFPGLRLAVPIAEVKYRSAFVDCPDQVP
VTW

>CYP165C4    Amycolatopsis orientalis GenEMBL AF486630
MGHDIDQVAPLLREPANFQLRTNCDPHEDNFGLRAHGPLVRIVG
ESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDP
PEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHA
LCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGL
LGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPE
KAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDP
DVLDANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYR
SAFVDCPDQVPVTW

>CYP165C5   Streptomcyes toyocaensis strain NRRL 15009 GenEMBL U82965 AF039028
MRRTLCDPHEDMFALRAHGPLIRIEGNASDQMSTDYVWQAMGYD
VVRKILGDHENFTTRLRLTDAQPLSGEGVSVPPELAGQISIYDPPEHTRLRRMLTPEF
TVRRIRRLEPAIEGIIEEHLDALEGAGPPADLQVLFADPVGGETLCELLGVPRDDRNE
FIRRVRQNVDLSRGYKARAADSAAFNRYLMTLITRQRKDPDEGFLGMLVREHGDRITD
EELKGVCTALILGGVESVAGMIGFGVLALLEHPDQRRLLFGSREEADRLVNELLRFLS
AVQQPTPRMAVRDVVVEGQLIKAGEYVLCSILMANRDEGLTSDSHLLDANREPLPHVA
FGHGIHHCIGAAVARAVLRITYQSLWRRFPRLSLAVPAGEVKFRNAFIDSPDRLPVTW

>CYP165C6   Actinomadura sp. ATCC 39727 GenEMBL AJ561198 complement(19681..20943)
MRIDSEWSFDPGMDDDIDAGAPVLQPTANYMMRTHCDPHEDMFA
LRAHGPLVRIGGDAATQLRVDYVWQALGYDVVRRILGDHENFTTRPRWSSAPSIAGEP
IPPNLVGQLSVYDPPEHTRLRGMLTPEFTARRIRRLEPAMQDLIDDRIDELEAAGPPA
DVQALFADPVGGGVLCELLGIPRDDRIEFIRRVRQNVDLSRGFKARAADSAAFNRYLN
GLIIRQRKDPDEGFIGMLVREHGDDVTDEELKGVLTALILGGVETVAGSIGFGVLALL
DHPDQRQSLFAGREEADRVVGELLRFLSPVQQPNPRLAVRDVVVDGQLIKAGDYVLCS
ILMANRDEALTPNANVLDVRRDCGSHVGFGHGIHYCIGAAIARTLLRMAYQSLWRRFP
GLRLAVSAEEVKFRNAFIDCPDELPVTW

>CYP165D1   Streptomcyes toyocaensis U82965 AF039028 complement(10263..11417)
MALPLPHRRHRLDPVPEFHDLQNEGPLHEYDTEPGMDGRKQWLV
TGYHEVRDILADPERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDLEDVGSPVDFVRYAAWPIPALIACEFLDVPRDDRAELSRM
IRESRESRLPRQRTSSGMGVVNYTQKLAARKRLDPGEGMIGVIVREHGAEVSDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREHPELVDGATEELLRHASIVEAP
APRVALEDVSVAGRDIRAGDVLTCSMMAVNRPQGEHFDITRENPKHMAFGYGIHHCLG
APLARLQLRVALPAVLRRFPSLRLAVPEEDLRFKPGRPAPFAVEELPVEW

>CYP165D2   Actinomadura sp. ATCC 39727 GenEMBL AJ561198 complement(22211..23365)
MVVPLPHQRLRLDPVPALFDLQEDGPLHEYDTEPGLDGHKQWLV
TGYGEIREILADANRFSSMRPVEDEAERAWLPGILQSYDAPDHTRLRRTVTRANTARR
IESLRPVVEETVEDCLADLESMGSPVDFVRNAAWPIPALIACDFLGVPRDDQAELSRM
FRDSRESRVPRQRNVSGLGIVDYARKLAARERLDPGTGMIGGIVREHGGEVTDEELAG
LVEGIMIGAVEQMASQLAIAVLLLVTHPDQMALLRERPELADSAAEEVFRYASIVETP
SPRTALVDTRLAGRDIHAGDVLTCSILAGNRAREDRFDLTRGNPEHLAFGHGVHFCLG
APLARLQAQVALPALVRRFPSLRLAVPAEDLRFKPGKPAPFAVEELPVEW

>CYP165E1   Streptomyces lavendulae GenEMBL AF386507 41015..42208
MASRDVPVYNRRDRLDPVPELVELRNRCPVLRTELHGGPSSQVV
GWLVTGIDESREVLSDQHRFTMLPPADTEAQSRRLQNIGNPLHYDPPEHTRLRKMLNP
EFTMRRLRRLQPRIDAVVEECLDAMEQAGAPADLMQHFAWQIPGHTACELLGVPRDDR
AELSRHLDITRDDGRGRARQMAAGRAYRAYFHQLTARQRRDPGDDLLGMLVREYGDEI
TDEELEGLAASLTSAGIENVASMLGLGTLVLLEHPDQLAELREKPELIDRAVEELLRH
VSVIPTLSPRTALEDVPLGGHVVPKGERVICSAFAANRIATPGDDLEDGFDITREPAP
HMAFGHGVHHCLGAPLARMQLRTAYQALWRRFPELRLAVPHEEIRFRMPSSRVYSVDA
LPVAW

>CYP166A1 AF040570 Amycolatopsis mediterranei rifamycin 
MTDAISFEVPWDRTDKFDPPAVFDSLREERPLAKMVYPDGHVGW
IVSSYELVREVLSDLRFSHSCEVGHFPVTHQGQVIPTHPLIPGMFIHMDPPEHTRYRK
LLTGEFTVRRASRLIPRAEAVAAEQIEVMRAKGAPADVVMDFAKPLVLRMLGELVGLP
YEERDRYVPAVTLLHDAEADPAEAAAAYEVAGKFFDEVIERRRQRPQDDLISSLVTED
LTQEELRNIVTLLLFAGYETTEGALATGVFALLHHTDQLAALRAEPEKLDAAIEELLR
YLTVNQYHTYRTALEDVKLEGELIKKGDTVTVSLPAANRDPAKFGCPAELDIERDTSG
HVAFGFGIHQCLGQNLARIELRAGFTALLRAFPELRLAVPADEVPLRLKGSVFSVKKL
PVSW

>CYP167A1 AF210843 Sorangium cellulosum strain gene="epoF"
MTQEQANQSETKPAFDFKPFAPGYAEDPFPAIERLREATPIFYW
DEGRSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSSAIPELSDMKKYGLFGLPPED
HARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRAISA
LLKVPAECDEKFRRFGSATARALGVGLVPQVDEETKTLVASVTEGLALLHDVLDERRR
NPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEA
LELVKAEPGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSAL
RDGTVFSRPDVFDVRRDTGASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLK
ETPVFGYHPAFRNIESLNVILKPSKAG

>CYP168A1 Pseudomonas aeruginosa NC_002516 complement(2792798..2794132)
MDDAFSEEGSAQPRHDAQRPALAPRSDGFDIHTYHPDFVADPYPLLRLIR
SRAPVCRDQASIWWISRYADVSACLRDRRFSADPARLGAAGVRQGGASW
FGHQQLQPLARFYDNFMLFNDAPRHTRLRRLFAPAFGPDAVRRWEARIE
VLVEELLDSLLERREPDLLRDFAEPLTIRVAAELFGFPREDTGQLLPWG
RDLAAGLDLAASHGDAGQINRSAVAFSDYLQRQARGWSDGSSRPPSGAA
PSILDGAAMLEAGLGLEDLVAAYAMVFMAAFETTISMVGNATLALLTHP
DQLDLLRRCPELAANAVEELLRFDGAVRGGVRCTLEEVEIGGQRIPPGE
KVWLSFLAANRDPEMFAAPDRLQLQRANAKQHVAFAHGPHYCLGAYLAR
LELQCALRGLVRRRFALASEPTDLRWRRSSVFRTLERLPIVPEGDAQKT
CE*

>CYP169A1 Pseudomonas aeruginosa NC_002516 complement(4121113..4122390)
MQQTIDCPIRRRLAHLPWANDGRAGVRHWLEMQRDPLAWLQKMHVAQPDL
AVARMGPQRLWCLFHPQAVQELMVDRRDDLQRWQPALCMLKQWNGRSFM
MREGAPAQARRKEVRPHLAPPPASEVRRLAAEWGERVEEGREYDLDLEM
AAFSVTLSGHALFDVDLQPSAYRIAKAVRLLSRVALLEMSTGLPLGHWF
PSKLCPRKRWALGQLREAVGEVAERSPRPLADLRDELCTLLMASHQSTG
VTLTWSLLLLAQRPELLARLRAELAGVNWTAIRSVADLRDCALLRAVLQ
ECLRLYPPAYGLAPRQVTADIEVFGQRLKRGDVTMVSSWITQRDPRWFE
APLEFRPERFLEPARWPRGAYFPFGLGDRACPGTAMAMIDLAAALAYWV
EHWDIMHDGDLAPRGWFSLRPQRARVRFRRRA*

>CYP170A1 Streptomyces coelicolor cosmid 7E4 
MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDP
LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKE
GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFR
VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND
ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS
ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL
RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERA
ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR
PHDLLVRPVAR

>CYP170A2 SAV3031 AP005033 Streptomyces avermitilis
MTLESVKPEAPEAPQLRNPPLAGGGIPGLGHGWKLARDPLGFLAQLRDHG
DIVRLKLGPKTMYAVTTPALTGELALSPDYEIGGPLWESLEGLLGKHGVA
TANGPTHRRQRRTIQPAFRLDIIPEYGPIMEEEARAFAARWQPGEIIDCT
SESFRVAVRIAARCLLRGHYMDERAERLSIALTTVFRGMYRRMVIPAGPL
YRLPLPANRKFDRALADLHLLVDEIVAERRASGQKPDDLLTALLEAKDDN
GDPITEQEIHDQVVAILTPGSETIASTIMWLLQVLTEHPEHAAKVCAEVE
SVTGDRTVAFDDVRKLSHTNNVVVEAMRLRPAVWILTRRAVTETELGGYR
IPAGADIVYSPYAIQRDPRSYAEHLEFDPDRWLPERSKDLPKYAMRPFSL
GNRKCPSDHFSMAQLTLITATVAAKWRFEQVSESSDATRVGITLRPHRLL
LKAIPR

>CYP171A1 SAV941_aveE AP005024 Streptomyces avermitilis
MMSQSTSSIPEAPGAWPVVGHVPPLMRQPLEFLRSAADHGDLLKLRLGPK
TAYLATHPDLVRTMLVSSGSGDFTRSKGAQGASRFIGPILVAVSGETHRR
QRRRMQPGFHRQRLESYVATMAAAAQETADSWSAGQVVDVEQAACDLSLA
MITKTLFFSDLGAKAEAALRKTGHDILKVARLSALAPTLYEVLPTAGKRS
VGRTSATIREAITAYRADGRDHGDLLSTMLRATDAEGASMTDQEVHDEVM
GIAVAGIGGPAAITAWIFHELGQNAEIESRLHAELDTVLGGRLPTHEDLP
RLPYTQNLVKEALRKYPGWVGSRRTVRPVRLGGHDLPADVEVMYSAYAIQ
RDPRWYPEPERLDPGRWETKGSSRGVPKGAWVPFALGTYKCIGDNFALLE
TAVTVAVVASHWRLHALPGDEVRPKTKATHVFPNRLRMIAEPRSVVRLEE
PAAMGA

>CYP171A2   Streptomyces nanchangensis GenEMBL AY129009 
MPAPLQVPDVPGSWPVVGHLPQLARRPLDFLSSLADHGDLVRIR
LGRKPVYVATHPDLVRSLLVTDAHAYTRGAGHAKALAFIGPILVATTGEPHRRQRRMM
QPCFHRQRLGSYVSAMCSAATETADSWSAQDVVDVVPVMTELATAMIAKSLFVSERAA
HAEAELRKTGNAILTVARMSAILPGIYRRLPTPGNRQLPPARTVIEETIAAYRAEGQD
HGDMLSTLLRTTDATGTGLTDEEIRDEVMGLAITGIGGPAAIASWIFYELGQNPDLER
RLHEELDTVLDGRPPSSQDLTRLVFTQRLVKEALRKYPGWVGARRTRESVRLGGHEIP
ADAEVMYSAYALQNDPRWYPDPERFDPDRWDPQQNATRVKKGAWVPFSGGVYKCIGDA
FTETETAVAVAVIASRWRLRPADGRSVRASHLATHVVPRPLRMVVEPRSRNKDEAERS
PHEAPQVSR

>CYP172A1   Campylobacter jejuni AL139078 comp(120285-121649)
MSECPFFPKPYKNKASTLLTFLLKRRSWLDGLYERSYKMQTGYV
KMPNFDLYVINDTKEVKRMMVDEVREFPKSAFLHELLSPLLGESIFTTNGEVWKKQRE
LLRPSFEMTRINKVFNLMSEAVADMMDRFSKYPNHAVIEVDEAMTFITADVIFRTIMS
SKLDEEKGKKILNAFVTFQEQSVHTAMRRMFRFPKWLSYVLGDCKRAKAGDVIRQVLS
DIIKPRYDMADNAEFEDILGSLLLVVDADTNKRFSFEEILDQVAMLFLAGHETTASSL
TWTLYLLSLYPKEQEKAYEEITQVLQGGVIEISHLRQFKYLTNIFKESLRLYPPVGFF
AREAKKDTQVRDKLIKKGSGVVIAPWLIHRHEEFWTNPHGFNPSRFEGEYKKDAYLPF
GVGERICIGQGFAMQEAILILANILKTYKLELEEGFVPDVVGRLTVRSANGMRIKFSK
RKL

>CYP173A1 Mesorhizobium loti AP003005.1  327049-328782
MDTQPAPFVPPAPKPRTSPPSTLEMIRIVYRNPLELWGEPTYNE
PWISANGVGGHLIVANDPGLIRHVLVDNAKNYKMATVRQKILRPILRDGLLTAEGEVW
KRSRKAMAPVFTPRHIFGFAQPMLKRTKEFVTRYEEGGASDIAHDMTLLTYDILAETL
FSGEIAGEPGSFANEIDRLFETMGRVDPLDLLRAPDWLPRLTRIRGRKTMAYFRKIVT
DTVKMREEKFRRDPDAVPQDFLTLLLKAEGPDGLTRSEVEDNIITFIGAGHETTARAL
GWTLYCLAESPWERNRVEQEIDEVLAREPDPTKWLDAMPLTRAAFDEALRLYPPAPSI
NREPIEPEMWKDLYIPRHAAVLVMPWVVHRHRKLWDRPDAFLPERFHPGNREKIDRFQ
YLPFGAGPRVCIGASFAMQEAIIALAILLSRFRFDTTAETKPWPVQKLTTQPQGGLPM
QVTPR

>CYP173A2   Sinorhizobium meliloti Genpept CAC41447                 
1 MDTRPEPFEP PAPVPRTGIP SRLEIIRTVL RNPLELWGEP SYTLPWIETK FINQRTLIVN
 61 DPGLIRYILV ENAANYEMSN VRRLILRPIL RDGLLTAEGE VWKRSRKAMA PVFTPRHAQG
121 FAGQMLRVCE AFVDRYAGAS SEPFVTNVAV DMTELTFEIL AETLFSGEIA VEKQGFAANV
181 EELLHRMGRV DPMDLLVAPS WVPRLTRIGG RKVLDRFRGV VSETMSLRRR RTTEAPGDVP
241 NDFLTLLLQL EGPDGLSTSE IEDNILTFIG AGHETTARAL AWCFYCVANT PAYRETMEQE
301 IDSVLASGAD PVDWLGRMPH VLAAFEEALR LYPPAPSINR AAIEEDAWTS PEGERVPIRK
361 GISVLVMPWT LHRHALYWQK PRAFMPERFL PENRDKINRF QYLPFGAGPR VCIGATFALQ
421 EAVIALAVLM HRFRFDLTDE THPWPVQRLT TQPRGGLPMK VSARVK

>CYP173B1   Magnetospirillum magnetotacticum GenEMBL AAAP01002719 
1466 NGLLTAEGDEWRLQRRTLAPIFSARHVAGFVAQMDAAGARLGRRLARRDGATVDIALEMT 1287
1286 RATLDVLERTIVHAKGLPGPIPDALGRAITRLLESVGPIDP 1164
1185 SDVFGFPAFVPRLGRLRAGRHCVSSRRW*HLLDGRKQALARGEAPHDLM 1015
1014 TLLLAAQDPETGRGLSDIEVKANIVTFIAAGHETTANALTWALYCLSQDGAARARVEAEA 835
 834 DAAAGPEGNLRLDRLPFTKAVMEETMRLFPPVPFLSRQALRDDRIGRVKIPRNSTVIV 661
 660 APWVMQRHRKLWDEPDAFIPDRFFGSRRESIERYAYLPFGAGPRVCIGQSFSVQEATLVL 481
 480 AHVARAVRFTLPDEHPPVTPLHRVTLRPKDGLRMVARRRM* 358

>CYP174A1 Halobacterium sp. NRC-1 AE004998 comp(560-1777)
MGPMETYVVTEPALVERLLVSDAAEFRKPEFQADAIDDLLGDGL
LLSEGESWREQRGRANPAFSMARVAGFDADIAAHAADRVDDWPVGDTVDVEAAMTHIT
LDVILDVMLGVSLPEARVDAIGDALEPVGARFEPDPVRFAVPEWLPMPDDREYAAAVA
TLDDLVDDIVAAREGTASGGDGDDPMDLLSVLLRARDRGEQSLDRLRDEVMTTLLAGH
DTTALTLTYTWFLLSEHPDVEARLHAELDGALDDGAQPTVAQLQDLDYLEWVLQESMR
LYPPVYNVFRTPIEPVELAGSEVPAGAPIMLPQWAIHRSPDHWDDPEAFDPERWRPER
RADRPRFAYFPFGGGPRHCIGKQLALLEAKLIVATVASDYRLRYEGDTPLSFVPSLTI
HPEQEMRMRVEPR

>CYP175A1 Thermus thermophilus AB001637 N-terminal only AX451783 full seq 
MKRLSLREAWPYLKDLQQDPLAVLLAWGRAHPRLFLPLPRFPLA
LIFDPEGVEGALLAEGTTKATFQYRALSRLTGRGLLTDWGESWKEARKALKDPFLPKN
VRGYREAMEEEARAFFGEWRGEERDLDHEMLALSLRLLGRALFGKPLSPSLAEHALKA
LDRIMAQTRSPLALLDLAAEARFRKDRGALYREAEALIVHPPLSHLPRERALSEAVTL
LVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQEALRLYPPAWILTRRLE
RPLLLGEDRLPPGTTLVLSPYVTQRLHFPDGEAFRPERFLEERGTPSGRYFPFGLGQR
LCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVLAQVTLRPEGGLPARPREEVRA

>CYP176A1 Citrobacter braakii  P450cin AF456128
MTATVASTSLFTTADHYHTPLGPDGTPHAFFEALRDEAETTPIG
WSEAYGGHWVVAGYKEIQAVIQNTKAFSNKGVTFPRYETGEFELMMAGQDDPVHKKYR
QLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGDAATWLANEIPARLTAILLGLP
PEDGDTYRRWVWAITHVENPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMSKI
DGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRLIAHPELIPNAVD
ELLRFYGPAMVGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTP
NRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHV
PIIFPKGKRLSE

>CYP177A1 Rhodococcus rhodochrous AF449421.1 Metabolizes explosive named XplA 
MTDVTVLFGTETGNAEMVADDIASALGEFDIEATVVGMEDFDVADLAASGTVVLVTSTYGEGELPATTQPFFDAMKAAEPDLTGLRFGAFGLGDSTYDTYNNAIDILVGAVTDAGATQVGATGRHDAASFQPADGPVAEWAKQFAEALSDRTRRGGHEMTAASIDRELVPWSDPEFRNNPYPWYRRLQQDHPVHKLEDGTYLVSRYADVSHFAKLPIMSVEPGWADAGPWAVASDTALGSDPPHHTVLRRQTNKWFTPKLVDGWVRTTRELVGDLLDGVEAGQVIEARRDLAVVPTHVTMARVLQLPEDDADAVMEAMFEAMLMQSAEPADGDVDRAAVAFGYLSARVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVFTAFRNDESARAAIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTRPPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIELAEEPTVAHNDFARRYRKLPIVLS

>CYP178A1 SAV838 AP005024 Streptomyces avermitilis
MIDLADLDLFTDGDPHEAWRVLRRDRPVHWNATGGDTASGVGPSGFWALT
RYQDVHDAYVDAGLFSSRWGTVMGGSHRRDADSASGRMLIASDDPQHRLM
RQQVHRAFLPALMDRARRVVRDYVNAALDRVLKDGGGDFATDVAPELPAG
LLAAMFGLERRDALHLLALTRSMIGFQDPRYHSDSTPPAVLVSSQVEIFD
VMMDLMETRRRAPSDDLVSILLGASINGRRFTEDEVLYNCLNVAVGGNET
TPFTASAAVQAFMDFPDQAQRLLDDGGLLPTAVEEIFRWTSTNAYVQRVA
TRDVELHGQLIRAGDPVTLWNASANRDEEKFPNPDRFDVRRTPNRHIAFG
VGVHRCIGMGAAQMEIALLLKEIVRRGITFEPAGPPARLRSNFMLGLTCL
PVHATVAQDAS

>CYP179A1 SAV2061 AP005029 Streptomyces avermitilis
MDLELHGRLDELQRDPYPHYARARRFTALEHVPELDAWLVARDADVREVL
RRPDDFSSANALRPDVMPAPAALAVLGGGFGGRPVVVTADGARHQELRAP
IVRGLSPARVAAVLPYAAERATALVDRFLSGAESGRVELMAAYARRLPGD
VIGRIVGLDPADVPAVVYGGHRAEELLFRPLTEDEQVVAAQDVVAMQHLL
DAFVRDRRADPREDLASEIIASVAPGDGELTLDQRHDIVAHLQNLLLAGH
LTTTALIGTTVLNLLRHPRQWELLCAEPERIPAAIEEAARYDSALQGFRR
VTTRPVTLAGTELPAGASVFVAFGGANRDGGRHPRPDEFDITRTPRRHLA
FGFGVHGCPGAQLAREQLRLTLEQLTRRLPGLRPADDRPVTMRPTLIHRS
PRSLHLVW

>CYP180A1 SAV2165_geoC AP005029 Streptomyces avermitilis
MSVREQAPPVPDVFDPRRYAAGVPHAAYRTLRDHHPVARQAEPEVLGWPA
GPGFWAVTRHADVVRVLKDSTTYSSRFGATQIRDPDPDDLPFIRDMMLNQ
DPPDHGRLRRLVSRAFTPRRVDRFESLARDRARTLLAAALAGARAGDGSC
DLVATVTDDYALLNLADLLGVPESDRGLLLHWTRRVIGYQDPDEAGEPLL
DAAGKPVDPRSPGALRDMFEYARQLASYKREHPADDIMTTLATDPELTGP
ELAMFFFLLTVAGNDTVRGAAPGGLLALAEHPEAYARLRARPQQLPSAVE
ELLRWHPPVLTFRRTAVRDTDLAGQRIRAGDKVVVFHASANRDGRVFTAP
DRLDLSRSPNPHVSFGDGPHVCLGAHFARLQLRVLYAQTLRALPAPRVAG
PPGRLVSNFINGIKSLPLQVA

>CYP181A1 SAV2385 AP005030 Streptomyces avermitilis
MLPAEYETLRERGIGQVELPTGKLVWMVVRPEYARIVLSDPRFSSDKTDD
RFPKLTPNSLMKLRYCAPFMINLDGPEHLKKKKSIMDEFSPEGLARLLPR
LRVAVEEKIDDMLRQPTKPVDLVKELAFPIAWQLQEMFLGIPAAELETMR
DNVWKLLLGTTTEAEEREAADRLNGHAEEVLKEKAKHLGDDMMSRLIVQE
REKHGEVNWYELAPLMLSNAQGIHNSVSTMISLGVLTLLNHPEQRPTLLA
HPDRMTTAVDEMLRYFSVNDGTPMRLATEDMLIGDTLVKAGDGVAVPTLP
VNRDPSVCPYPHQLDIMREEPARHLAFGHGPHKCPADRLVPSLLEIVYTT
LFERVPTLALAVPEAELTYKYHSIQAFGPAEMPVTW

>CYP182A1 SAV2806 AP005032 Streptomyces avermitilis
MHGRCGMRSGMEAQPYATAPAGSPRLESLRVEPLLTSEFDADPAGVYERL
RRTYGPVAPVGLMGVPVWLVLDYHEVLEVLRDDSQWRRDIRYWRARAQGQ
LPRDWPLLAGYEVRQTMFLDGDEHHAARLTHHSALRPFQDGHSPQGWELR
AAVARYADELIALLAAESGSAGYADLGAQYTRPLLLMVTGKLFGCPVGLG
DELVMDLWRMLDGGPDAGPATDRAAAVMTRLAAHRRQRPGDDLTSYLLLA
DPGMTDEQLGRELLMNAVYLNDITGNMVMNTLLEVLRGNATVRRSVSDGH
LGETFHRVALVNPPVANMCFRFAAGDVRLGAFWIRAGDVVSPSAAAAHQD
LLTIGTSPLGDATASTRAHLGWGAGQHQCPGAARELAGMIVTTAVGRIFD
HFTKAELTLPADQLPWRSGPVVRGLRLLPVRYELRGTPSESHPVPPPRHD
GEAPDTAPTADHRSRGLLSALRRLMTGTGRAG

>CYP183A1 SAV2999 AP005033 Streptomyces avermitilis
MSQHTFVAGTAPGAVPVVGHAWQMMRRPLHFMSSLSAHGDLVKIRIGPTS
AYVPCHPELLRQVLTNDRVFDKGGVFYDRARDIAGNGLVTCPYRDHRRQR
RLMQSAFQRTQLERYSTAMRAEIDATAARWHDGTVIDAFPELYGMALRTV
ARTLYSTPVTEELAQRVEQAFDTVLNGLFRQMFLPHSLRRLPTPANLRYR
NNLRFLHDTVQDLITEYRRDDTQRDDLLSALLASRDEDGGRLGDTEIHDQ
VITVMAAGTETVAGTLTWIFHLLSRHPEIEARLYEEIDTVLDGKPPHWDD
LPSLSLTDRIITEALRMYPPAWIFTRLTASDVDLAGVRLPEGTTIVFSPS
SVQRHSEAYDDASRFDPDRWLPDRTSAVARQAFTAFGTGARKCIGDLFAR
TEATLALATMLSQWRVTVEPDADVRPVALATVYHPRRLRLRLTARTPGQ

>CYP184A1 SAV5111 AP005041 Streptomyces avermitilis
MAAVTAAGAAQAPIVAGHPLLGSMNDLLNDPLATYLRARRDHGDVVRFRA
GPPGLRADIYAVFSAEGAQQVLATESGNFRKDNVFYGELRDSVGNGLLTS
QDATYLRQRRLVQPLFTRRRVDGYAGQVADEAAGLAEAWRGIPGGGVELV
GEMHRFALRVVGRILFGTDMETTFEVIERTLPLLQEYALKRGLAPVRTPR
TWPTPANRRAARTQAELFALCDGIIDSRRNRKNEGDGGEESGEDLVTLLV
RAGNAEDGSLDAAELREQVLIFLLAGHETTATALAFALHLLARHPEQQRR
VRDEADRVLGGPGGRAPTAADMEALPYLTMVLKEAMRLYPSAPVIGRRAV
ADAEVDGVRIPAGADLFVSPWVTHRHPDYWPDPERFDPERFTPEAEAGRP
RYAWFPFGGGPRACIGQHLSMLESVLGLAVLIREFEFEAVGEEEVPLGAG
ITLLAKGPARCRVIPRSSGPRSS

>CYP185A1   Mycobacterium smegmatis MSMEG0814 TIGR
MRADTRFMVETASPPLTELPLAPRNTLPCREQIRCLRSFIDGMQRLRDVGGPVTRIV
LGPRWLVPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQLQRLMGGNLL
DLPHDRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWADGATVDLD
RACRALTLRALGRSVFGVDLDQRAEDVGPALRTSLSWVADRASRPVNLPQ
WVPTRGQRKARAGNATLHRLAAEILADVRADPDRDAPLVRALLEARDPET
GRGLTDDQICDELVLFMLAGHDTTSTTLCYSLWALGHHPDIQERVYAEVA
ALGDRELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMTVDGYRV
EAGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAGRNRWQYLPFGGG
PRSCIGDHFAMLEATLALATVIRAVSVESQNTDLPVETPFTVIAAAPVPA
RVTRR

>CYP185A2   Mycobacterium smegmatis MSMEG0958 TIGR 
MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVRAL
DMGQQVIRAAGGAVTRVQFGPRWLVPPLVAVFSPEGIRDVLGRNDAFAER
CIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTKHSVRAFGGHMSRAA
QTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGRSVLGIDLNERADVIV
EHMHVASSYATDRALRPLRAPRWLPTPARRRARAAVAAMRAVTAEILQAC
RDDADRDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATAL
TYALWALGHHPEIQDRVAAEARALGDRELTPADVPQLGYTVQVLHESLRM
CPPAAGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPDPEVFDP
DRFSPENSRERDRWHFIPFAGGARACIGEHFARLETTLALATIIRSVVVG
SVDAEFPVDVPFTTVAKGPIRANVAPRGPDHYTL

>CYP185A3   Mycobacterium avium subsp. Paratuberculosis  GenEMBL AE017231.1 
MSVAEPKRDIAGLPLAPKNPLSYRERLRAIKEFHTGTNKLRDAG
GPVTRVTLGPRWLISPIVLATSPQGIRDIVSVRDGSIDKTSTVATELRRLLGPNLFVL
PHTEWLPRRRTLQPVFTRQRVREFGGHMAEAAESVCAGWPEDTEIDLDAQCRTLTLRA
LGRSVLGLDLDERSDAIAEPLRVATSYAVRRALRPLRAPEWLPTPSRRRARAAAGAIR
ALADEILQACRADPGREAPLVHALIAATDPETGQALSDKEIRDEMIIFLFAGHDTTAT
TLTYALWALGRHPEYQARVAAEVAELPDRHLTPDDVARLGFTVRVLQEALRLCPPGPT
GTRMATRDVEVAGYRVEAGTMLAFGRMAVQTDPSLWDAPLRFDPDRFDPRRAGDRDRW
QYLPFGGGPRSCIGDHFAMLEATLALATIVRRVEIESLSDDFPLAVPFTMVAAAPIRA
MVRRRR

>CYP185A5   Mycobacterium vanbaalenii PYR-1 ZP_01204630.1, EAS25622.1 
MVGTVEREDLGALPLAPRNPLPYRQQVRAIRTFHTGLETLRDAGGPVTRLKLAPKWLMPPMVVATSPQGA RDILARGGGHIDKTRVHHEMRRLLGANLFDLTHEPWLPRRRALQPIFTKQHVREFAGHMATAAQTVADSW ADGTELDLDTECRKLTLRALGRSVLGLDLDEHSDAIAEPLRTALEYIADRALQPISAPRWLPTPARRRAR AASSTLHKLADKILQACRTDPTRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYA MWALGHHHDVQDRVRAEVVGIGDRELTPEDVPALGYTIQVLHEALRLCPPAAATARMAMRDVEVDGYRIE AGSMMAVGIYALHRDPALWERPLVFDPDRFSAQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLALATI IRSAEIRSSDPHFPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR

>CYP185A6   Mycobacterium vanbaalenii PYR-1 ZP_01204233.1, EAS25225.1 
MTARDTAAAPEVGSLPLVPRNPLPLWKLVQLVRRLDTGQEVIRDAGGPITRIQLGPKKLMPPIVAVMSPA GMRDVLGRNDASSDRCIIHEQVQEMAGDSLWVLPNEQWRPRKRALAPVFTKTSVRAFGGHMSKAAQAFVD RWPSGGEVDLDAECRRVAMQSLGRSVLGVDLNERGETIARCMHVASSYTADRALRPVRAPRWLLTPARQR ARSAVNAMRAITDEMVKACRDDPTRDAPLVQALIAATDPETGRPLTDEEISNDLLIFMLAGHDTTATALT HALWVLGHHPDIQDRVAAEAAAIGDRELTPDDVPALGYTVQVLHESVRLCPPAAGVARLVTRDFAVDGYR VEAGSLVALGLYALHHDPALWPDPMAFDPDRFSPENVKARDRWQFLPFLGGGRPCIGEHFARLETTLALA 
TVVRACRIESLDDLFECEVPLTTVAKGPIRARVTPRR

>CYP186A1   Mycobacterium  smegmatis MSMEG1773 TIGR 
MSDGGHQLRGAQALATLVDLGFPAIASGVIARRPPVLGLLERMQADERAGRR
MHRLRSEFGRGPVELVIPGRRIVVVTDPEDVAAVLVQAPEPFHPANRE
KRKALQWFQPHGVLISQGPIREQRRTVNEAALDSGAAMHRLAESFAAKVA
AEADTLVARTLPGQRLDADEFMTAWWRLVRRLTLGERARDDHAITDQLAR
LRRAGNWSFLSLPHYRARSRFLSHLYRYAEDPEPGTLVGALADVPAGGAV
DPVGQIPQWLFAFDAAGMALLRALAVLATHPLQRDRALEDAGEPNRPLLR
PYLRGCLLESVRLWPTTPAILRDTTEDTHWREGAERFTVAKGAGLLIVAP
AFHRDDQVLPFAHDFVPEIWIDGRAQLYPQLVPFSAGPAECPGRNLVLFT
TSTLAANLLNRLHFDVRSEPRPVPGEPLPMTFNHAGIEFSLRPARRAVTA
ATVDPAT

>CYP186A2   Mycobacterium sp. JLS  ZP_01278281
MGASGRRLTG ARAAATLADL GPASTAARAV RRMQQLREQF GAGPVELVLP GRRMVVVLDP
DDVRRVLAGA PEPFHPANRE ERKSLEWSQR RDLDDAALDS GAEMHRLAGA FGDVIAAEAR
ELTDEVTARG TMDANQFMAA WWRIVRRIAL GDRARDDDEI TDALLRLRRA RNWSFLSMPH
YRTRARFLER LYDYVEDPQI GTLAAAVPAS GAVDPVGPLP QWLFAFDAAG IAQLRALAVL
ATHPAAMARA IEDAAEPDRL RLRPFLRACV LESVRLWPTT PTILRETTEK GAGLMIVTPA
FHRDPKLLPF ANDFVPDIWL DGRARSYPQL VPFSAGPAEC PGRNLALFTT STLLANLLSA
LDFRISSMPH LSPDEPLPVT LNQHGLEFAV VTAPRWRHHR AGSAVRS

>CYP186A3   Nocardia farcinica AP006618.1, YP_120573.1
4523238  MSGRHPETVARDQDERSPAPVPTS
4523166  AEHGRRLDGTRAVAALTDLGFAAIAAGVIARRRPVMGLLEKAQADSRALQRMRQLRREFG  4522987
4522986  AGPVELVVPGRRIVVLLDPGDVGRVLAEAPTPFHPANREKRAALRQFQPHGVLLSKGVVR  4522807
4522806  EQRRAVNEAVLDTDAPLHRLAEPFAAIIADEAAQLMASALQRGHLDAEHFTIQWWRMVRR  4522627
4522626  LVLGERGRDDSAITDELWRLRSAANWSFLAPPHRRRREVFTEQLYRYVERPDPNSLAGAV  4522447
4522446  AAVQTGGAVDPVGQIPHWLFAFDAAGMAAQRALAVLATHPDQQAAATADAADPHQVHLRP  4522267
4522266  YLRACVLESVRLWPTTSTILRDITEPTQWRAGADAFTIAPGAALLILVPAFHRDADLLPF  4522087
4522086  ADRFAPEIWLDGQAAQYPQLVPFSAGPAECPGRNLVLFTTSTLLAHLLAAAEFRLRSGHR  4521907
4521906  MSPQTPLPLTLNNFGLDFDVTRLPNVAS*  4521820

>CYP187A1   Mycobacterium smegmatis MSMEG2245 TIGR 
MDSRIRDDPAVDTAALLRDPYPIFARYRAQAGVFRGSVMDWSKTPKELMP 
EHQYAAMSFDAVNTVFRDGKTFNSKIYDSTIGLFIGPSILAMEGKTHRDH 
RNLVSAAFKSKSLARWEPEIARPICEALVDEFVDTGSADLVRDYTFEFPT 
RVISKLLGLPEEDLPWFRRRAVELISYSVKYKRAFEASAALKDYFLDQIE 
RRRSRPTEDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGN 
LLYLLLTHPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELE 
GVQIPAGAVIDVCIGSANRDENRWERPEEFDIFRKRIPHITFAAGEHTCM 
GLHLARMETRVAMETLLNRVTDLRLIADDDPHIFGQPFRSPTAIPVTFRPAG

>CYP187A2   Mycobacterium avium subsp. Paratuberculosis AE017235.1 
MMTNVPTAAGDETVSLRDPYPFFARKRREAGVFAGTVMDYSKTP
ESLMPKQEYSAVSFDAVNTVFRDGRVFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNL
VSAAFKSKALARWEPTIVRPICNALIDDFIDAGTADLVRQFTFEFPTRVIARLLGLPD
EDLPMFHTRAVQLISYHVDYERAFEASAALKDYFLEQIEQRKSKPTEDIIGDLVTAEI
DGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPDQFAALQADRELLAPAIE
EGLRFETPLTTVQRFTTEDTELQGVRIPARSVIGVCIGSANRDERRWERSEEFDIFRK
HVPHISFAAGEHTCLGLHLARLETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTA
LPVTFDAK

>CYP187A3   Mycobacterium avium subsp. Paratuberculosis AE017235.1 
MPLSTGPTGQPVVPTLDFTGETSPYPFFEHMRRTDPVWHGSLAD
ASQLPEELRPEDEWVLFDYESVSQAFRDDRIFSSHKYDETIGLVMGHTILAMGGREHH
DHRNLVAKAFRATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTL
LGLPAEDLDLFRRLSLDLISIPTDIEAGLNAATELYDYFLKQVEQRRRKPTDDIIGDL
VAAEIDGEKLTDEAIIAFLRLLLPGGLETTYRSSGNLLYLLLTHPEQLAMVYRDRSLI
PMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAF
DIRRPRQAHIAFAGGIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIV
GLTFRSPNKLPVTFAPAA

>CYP187A6   Mycobacterium vanbaalenii PYR-1 ZP_01203863.1, EAS24855.1 
MDQRPGRARRFGVRHVDDGGHSDRAVARRCTGKYCKRYSNEMETPVQDLAKDEPIDLRDPYPMFARRRAE GGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGKVFNSHIYDSTIGLFIGPTILAMEGKTHWEH RNLVSAAFKTRSLARWEPEIVRPVVNELIDEFIDDGRADLVRDFTFEFPTRVISRLLGLPEEDLPWFRKR AVELISYAVNYKKAFEASAALKDYFLGQIDKRRSAPTEDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAG LETTFRSSGNLLYLLLTHRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPAGSVI DVCIGSANRDESRWERAEQFDIFRTRTPHISFAAGEHTCMGLHLARMETRVAAETLLSRLSAIELLTDGD PHIHGQPFRSPTALPVTFTPSRARP

>CYP188A1   Mycobacterium smegmatis MSMEG4791 TIGR 
MSIQDVTTDDDREKITYHFDRHTPEYRLQFEKITEEMHSRCPVAWTETYD 
GHWVAAGSNEVFELARCPVVSNHHDISGETPFQGITIPKASRATVVRGGI 
LEMDEPEHSAYRGALNPYLSPAAIKRWEPFVDEITRAAIDEHISSGRIDF 
VEHLANVVPAVFTLAMMGIELKKWNVYSEPTHASVYTPEHAPEREKINEQ 
HREMGIDLINNMMEIRQNPRPGLVNALLQL 
RIDGEPAPDMEILGNLGLII 
GGGFDTTTALTAHALEWLGEHPDERERLSRERDTLLNPATEEFLRFFTPA 
PGDGRTFAEDAEVAGYKFKQYERLWLSWAMANRDPSVFDKPNEVILDRKG 
NRHFSFGIGVHRCVGSNVARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTI 
GVIQGMRNLPATFTPSRPLGPGLDETLEKLQRICNEEELARPITERKERA 
VID

>CYP188A2   Mycobacterium avium subsp. Paratuberculosis AE017229.1 CDS 
MPDAWTDTYGGHRVAAGSHEVFELARCPAVSNDHDINGERRGYK
GISIPTASRVSAVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWEPFIDEVTRAALDE
KIEEGSIDFVDDLANIVPAVLTLAMLGIPLKKWKMYSEPVHAAVYTPEHSPDIERVTA
MHREMGLDMVNNMLEIRENPRPGIVNALLQMRIDGEPAPDLEILGNLGLVIGGGFDTT
TALTAHSLEWLSEHPEQRQLLSDERKTLLDPATEEFLRYFTPAPGDGRTFSEDFELDG
TVFKEGERLWISWAMANRDPAVFHDPDEVILDRKGNRHFSFGLGIHRCIGSNVARTVF
KSMLIAVLDRMPDYRCDPEGTVHYETIGVIQGMRKLPATFTPGRRIGAGLDETLEKLQ
RICDEQELARPITERKEAAVID

>CYP188A4   Mycobacterium vanbaalenii PYR-1 ZP_01205759.1, EAS26751.1 
MSVDDVVSGTADDSRKQNRYYFDRHTPEYRLQFEKITEEMQTKCPMAWSDTYGGHWVAADSKHVFELARC PVVSNHHDISGETPFQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWEPFIHEITRA ALDEHIESGRIDFVDHLANVVPAVFTLAMMGIKLDKWNVYSEPTHASVYTPEHAPEREKINEQHRAMGLD LITNMMEIRENPRPGLVNALLQLRIDGEPAPDIEILGNLGLIIGGGFDTTTALTAHALEWLGEHPDQRQR LSSERATLLDPATEEFLRFFTPAPGDGRTFADDVEVEGQRFKKFERLWLSWAMANRDASVFDRPNEVVLD RKGNRHFSFGIGVHRCVGSNVARTLFKSMVTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPGK 
RLGPGLDETLEKLQRICDEQELARPITERKEAAVID

>CYP188A5   Mycobacterium vanbaalenii PYR-1  ZP_01203997.1, EAS24989.1 
MADQLDRRREARSFHFDRHTPQYRDRFQEITAQMQARCPLAWTDTYGGHWVAAGNREVFELARCPHVSND NDIDGTRRGYTGINIPRGDYSVAFRGGMLEMDDPEHREYRSPLNGYLSPAAVRRWVPVVDELVKACLDEK IEDGRIDFVDDLANIVPAVLTLGLLGVPLKDWEIYCEPAHASVYTPADSPDFPRVADLAIASAMGMMHHV AEIRQTPRPGLIDALVRTRIDGQPAPDTEIMGMLMLLIGGGFDTTTALTAHALEWLSQHPDERERLSRDR DTLLDPATEEFLRYFTPAPGDGRTVAEDIEVDGVVLKEGERLWLSWAMANRDPALFQNPDEVVLDRKGNR HFSFGLGVHRCIGSNVARTVFKSMLTAVLDRMPDFQCDAAGAVHYETIGVIQGMQHLPAAFTPGPRLGPG 
LEATLEKLQRVCDEQQLAAPITVHKAAAVI

>CYP189A1   Mycobacterium smegmatis MSMEG4818 TIGR
MPPFDDGVPMAQPSTSATPDLYYDPYSVQLNMEPHEVFARIREEAPLYYN 
EQHDFYALSRYHDVNKAVIDHETFISGRGALLELIKSGMEIPPGTLIFED 
PPIHNIHRNLLSRMFTPRKVLALEPQIREFTTRCLDAVAGSDTFDFVNDL 
GEQMPMRVIGMLLGIPEDRQRAITDHGEETLQGTTVDSLATGEVFAEFID 
WRADNPSDDIMTDLLNAEFEDETGTVRKLRRDELLLYLTVIATAGSETTT 
RALGWAGKTLADHPDQRRDLVENPALIPQAIEELLRWEPPALQIARYVTR 
DVEYYGKTVPAGSAMLMLVGAANRDHRRFPPNGDVFDIHREQFSHMTFGA 
GTHFCMGNALARLELRVALEEILKRFPEWEVDWDNARPSETAAVRGWAAM
PTFVR

>CYP189A2   Mycobacterium smegmatis MSMEG4873 TIGR
MTASATQNVYFDPYDVAINADPYPTFARLREEAPLYYNEQFDFYALSRFS 
DVNKALIDHETFSSARGAIVELIKADIEIPSGALIFEDPPIHTAHRKLLS 
RMFTPRKINALEPEIRRFCAQSLDAVAGVERFDIIKDFGAIMPMRVISAL 
LGIPEEDQEKIRDHGNAQMRTEAGKPMKAAEEGLVDGSIFEAYIDWRKDN 
PSDDIMTELLNVEFTDEHGVTRNLTREELLIYINVVAGAGNETTTRLIGW 
AAKTLAEHPDQRRQLVENPALIPQAIEEILRFEPPAPHVARYVTRDVEYH 
GRTVPEGSVMMLLIGAAVRDSRQFPPDGEVFDINRAPRQHLAFSVGTHFC 
LGSALARLEGRVALEEILKRFPEWDVDLASAELSPTSTVRGWDSLPVIVR

>CYP189A3   Mycobacterium smegmatis MSMEG3700 TIGR
MTVDDSGVVVTGVAGPYYDPYDVGIVADPYPVYARLRDEAPLYHNERYGF 
WALSRHADVESALANWETFSNSRSDILELVKSDFDMPPGVMMFTDPPMHT 
MLRGLMSRVFTPRRMAEIEDQIRRYCVRCLDPLVGSDRFDIIAELASTMP 
MRVIGMLLGIPESEQIGVRDANDANLRTKPGAPMKVAQADKIADGRIYAD 
YVEWRSKNPSDDLMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNE 
TTGRLIGWLAKVLAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARW 
VARDFEAYGQTVPAGSAMLLLFGAANRDPRRYTDPDVFDIHRDNISHLTF 
GKGLHYCLGANLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWE
RLDVLVG

>CYP189A4   Mycobacterium smegmatis MSMEG6584 TIGR
MRVLDELSYDPYDVEIDVDPYPTYRRLRDEAPVYFNGRFGFWALSRFADV 
EAALRDVDNLSNAKGDILEVVKAEPKMPLGVFINEDPPLHTVHRLLVSRA 
FTPRKMRAIEDQIRTFCAACLDPLTSGDRFDFTLDLGAEMPMRVIGMLIG 
IPEELQRSVRKVAGQRLRNKPGEPLPVNKDNYFNGNMFRDYVEWRAQNPS 
DDLVTELLNVEFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLG 
KLLGEHPDQRRALVADPSLIPGAVEEVLRYEPPVHNIARYVSADVDYHGQ 
TIPAGSALLLMTGAANRDERRFDDPDRFDIRRSPNHLSFGRGAHFCLGAS 
LARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG

>CYP189A5   Mycobacterium avium subsp. Paratuberculosis  AE017234.1 
MVMTGTSAIELYYDPFDSGIDDNPYPVWQRMREEAPLYYNEKYN
FYALSRYEDVARELPNWQTYRSGRGTTADILFSNVEVPPGILLFEDPPLHDLHRRLLS
RVFTPRRMLAVEDLVRGFCVRELDPLVGAGGFDFIRDLGAMMPMRTIGYLLGIPEEDQ
EKIRDRSVANIELSRDSDPAAVDANVFANSIALFADYIEWRADHPSDDLMTELLRAEI
DEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQLLSDHPDQRRELAADPSLI
PGAVEETLRFEPPSPVQARYVARDAEHYGRVVPEGSFMLLLNGSANRDPRRFTDPDRY
DIHRQGGGHLSFGQGLHFCLGSALARMEARVAFEEVLKRWPDWEVDYANAERARTASV
RGWARLPVVTGG

>CYP189A8   Mycobacterium vanbaalenii PYR-1 ZP_01203775.1, EAS24767.1 
MADDLYYDPYDQGIVADPYPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILELIK SDFDMPKGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRRYCVNCLDPLVGSDGFDVIAELAAMMPM RVIGMLLGIPESEQVSVRDANDANLRTRPGAPMKVADPDRIADGRIYSDYVEWRAANPSDDLMTALLNVE FTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKVLAEHPQQRREIVEDRSLLGRAVDETLRFE PTGPHVARYLARDFEYDGTTVPAGSAILLLFGAANRDERRYRNPDTFDIHRDNISHLTFGKGLHYCLGAN LARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG

>CYP189A9   Mycobacterium vanbaalenii PYR-1 ZP_01205817.1, EAS26809.1
MTISADDSDVQNADTAAELYYDPYNVDLNMDPHGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQ TFISGRGALLEIIKSGMEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIREFTARCLDPLTGTN RFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDHGEATLQSDSVDLMATGEVFAEFIDHRTEHPSDDIMT DLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKTLADYPEQRAQLVADPALIPQAIE EILRWEPPALQIARYVTRDVEYYGQVVPEGSAMLMLVGSANRDHRRFPPNGDVFDIHRELRSHMTFGAGT HFCMGNALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS

>CYP190A1   Mycobacterium smegmatis MSMEG4807 TIGR pksS
MTTPQMIFDPFSEQYFENPFDIYRQMRDDAPLYYDSEQDFYALSRHEDVA 
AALKDHEAFSSSRGCDLAMVKGDEPPQKSIIFMDPPEHRHMRSLLNKAFT 
PRAVQAQRDTVVEQVEHYLGQIDSDEFDVVQDFSGPFPVEVITRMAGVEP 
EYRQQVRHWIDTSLSREPGQVAYSEAGMKANIDTAMYYYSLVQKRRENPQ 
DDMISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAM 
VTFAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSG 
TIPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGIHSCL 
GAALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR

>CYP190A2   Mycobacterium avium subsp. Paratuberculosis AE017229.1 
MTKPKLVFDPYSEDYFNNPYEIYRRMREEAPLYYDEKEDFYALT
RHVDVAAAFKDYETYSSARGCDLAMVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTP
RAIQSQRETIIEVVDKYLSAADPDNFDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
IDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQDPQDDMISRLIAAEIPGENG
QMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVIFARHPDQWQKLQEDRDKIPGAVE
ELLRYEGPVQYNVRYTLKEAHVSGGVIPAGKPVFLCGAAANRDPEAFTDADTFDIERD
QTEAQHLGLGYGIHSCLGAALARLESRIALERLLDFMPRYDVDWAGCRRVTMQNVAGW
KNVPVKVLR

>CYP190A4   Mycobacterium vanbaalenii PYR-1 ZP_01205773.1, EAS26765.1 
MTAPELRFDPVSQDYFDNPYEIYRRMRDEAPIYYDAEEDFYALTRHEDVAAALKDHEAFSSARGCDLGMV RSEDGPVKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETVIELVEHYLSKVDPDNFDVVQDFSGPFPVE VITRMAGVPEEFRQQVRHWIDKGLERKPGQIEWSDENMQANIDSGVYYYGLVQERRRNPQDDMISRLIAA EIPGENGEMRKLDDIEITGFTSLLGGAGAETVTKLLGSAVVEFARHPEQWQMLLDDRNLIPDAVEELLRY VGPVQYNVRYTVKEAHVPSGTIPAHKPVFLMKAAANRDPRAFDNAETFDITRDRTQAQNLGLGYGIHSCL GAALARTETAIALEHLLDFMPRFEVDFSGLQRVNMQNVAGYHHVPVKVLR

>CYP190A5   Mycobacterium vanbaalenii PYR-1 ZP_01203858.1, EAS24850.1 
MAVVDVGRDPVVFDPFSEEFYRDPQGCYPRLRAEAPVYYNATYDFYALSRHADVAAGLKDFATYSSAYGV DLGMVRRGEKVPAKMIISIDPPEHRAMRSLVNKVFTPRAIEALRTMVTDTVTRFLSAVRGDSFDVVQDFS VYFPVDVITQMLGVPEKYRQQVRLWIDESLHREPGQIDMSEAGMQAMAETWLMYYDLIKQRRADPRDDMI SALIAAEVEREDGTVDRLKDSEIAGFATLLGGAGAETVTKLVGSAVVTFARHPEQWQQLLDDRGKIGVAI EELLRYDAPVQYNVRRSNHPVTLHGVTIPAGAPVFLLGASANRDPDAWTAPDVFDINRDRTEAQNLGFGY GIHSCLGAALARLESSIALDMLLDFMPRYGVEWDGCRRVSMQNVSGWANVPVRIL

>CYP191A1   Mycobacterium smegmatis MSMEG2565 TIGR
MTTTVKPPVTEAVTGEFSYDPFDPAVMADPTPYYRVLREKYPLYHIEKWD 
TWALSRFSDIWEVLEVNDGTFVASEGTLPAATVLAEHNDGAVPDPPWHPM 
PFHANFDTPIYDSVRRCTSPQFRPRSVTKLADRIRTLANERLDELLPRGQ 
FDLTQDYGGIVAASVVCELVGLPVDLAADVLATVNAGSLAEPGSGVEVAN 
ARPGYLEYLTPVVQRRRAGEGRELPIVDNLLQYRLPDGSAFSDLEAAVQM 
LGVFIGGTETVPKIVAHGLWELTRHPEQLAAVRTDLDANVPIAREEMIRF 
CAPAQWFARTVRKPFTLHGTTLQPGQRVITLLASAGRDEREYPDPDSFIW 
DRRIERLLAFGRGQHFCLGVHLARLEITIMVTEWLKRVGEFRVDERAARR
PPSSFQWGWNNVPVEV

>CYP191A2   Mycobacterium avium subsp. Paratuberculosis AE017240.1 
MDFAYDPFDAEVMANPLPYYRILRDHHPVYYMPQWDTFALSRFD
DIWRVLEVNNGTFVASEGTLPPASVLAQHNDGPVDDPPLHPLPFHAMFDADLYGEIRR
THSRPFRPRAVTDLEGRIRTLANERLDELLARGSFDLTQEYGGVVVATIVCELLGIPT
DLAPQVLAAVNAGSLAEPGVGVDTGQARPNYFEFLLPAVQRRRADPSGPPLEVVDGLL
GYQLPDGSALDDLEVATQMLCIFIGGTETVPKIVAHGLWELSRHPDQLAAVRADPQHN
IPVAREEMIRYCAPAQWFARTVRKPFDIHGQTPNPGQRVITLLASANRDEREYPDPDD
FVWDRPIRRSLAFGRGQHFCIGYHLARLEVAVLLQEWLRRVPDYAIRADAATRLPSSF
QWGWNKIPVEV

>CYP191A4   Mycobacterium vanbaalenii PYR-1 ZP_01206303.1, EAS24065.1 
MVDIPARHRRQRRGPDHVRRAQQQDAGAVAGIGFPGRPGDSGSHADQAGPAGRLHQGTGTPLRAVVGVDG QALARLLHHHLQVQRGDPLLGARRRLGLLRESLPVVEGQPAGRDRHLDERRPRTARRLGGLHPGRPAPVP AAVSAKMSAAQQPDCRPGRRPFTYDPFDPDVMADPLPYYRVLRDEHPVYYLQKWDTYALSRFDDIWNVLE INDGTFVASEGTLPSAAVLAGHNDGPVADPPLHPMPFHANFDAPIYDEVRRCTAAPFRPRNVAKLADRIR VLANERLDELLPRGRFDLTQEYGGIVAASVVCELVGLPADLAPDVLATVNAGSLAQPGSGVEVANARPGY LEYLTPVVARRRAGQGSELPIVDNLLNYRLPDGSALSDTEAAVQMLGVFIGGTETVPKIVAHGLWELSSR PDQLAEVRSDMDANVPVAREEMIRYCAPAQWFARTLRRPFTLHDTTMRPGQRIISLLASANRDEREFPDA DRFVWNRPMPRLLAFGRGQHFCLGAHLARLEIAIMVTEWLKRVPEFRVDTAAAFRPPSSFQWGWSELPVE V

>CYP192A1   Caulobacter crescentus CB15 GenPept AAK24959       
1 MDADVRSAPL IPPAPKVHPR QLGGSFVGEL RIALEMSRNL MGAWCEEDFD NLFTPYVFMG
 61 QPGMVVSDPA AARRILSSPN YVRPVKAARS VRPIAGDGLL LSEGETWRRQ RKSLAPVFTP
121 MAVEGLLPHF VAAGASLAEA LSGHARADLS EAFHHATLDA VLSALFSRRA DAQGDQLAYM
181 VRRYMEGPAH FNLMDFVSRG ADDLTFLDVE RRRQGAAWFQ AVEHLIAQRQ AHPHAEARDL
241 LDRLLAARDE DGAPLSNQEI RDQCGTMLVA GFETTSRLLF WATYLLALDP ATQDRLRAEV
301 LAAPAAAVRT LDDLQAWPLM RSVLFETLRL YPTAPLLARE AIGPDTVMGH AVVPGQIITI
361 SPWLIHRHRK LWDAPTAFVP DRFIDQPHPW GIEAFLPFGA GPRVCIGASF ALAEAQIVLA
421 SLLERFEIGL VSDRPVIPIA SITLGPDHAP AFTLTPVS

>CYP193A1   Bradyrhizobium japonicum USDA 110 GenPept BAC52277    
1 MARGCASRCS RPVSDASPAP RAGTLSGARL ECRLCRFMAL DERCLCVCRC PLLWVMRTRY
 61 RARTPCPNRW GQTAAPERAS LAGHSRETAL STAPRIDIDP AAFWADPYPM LANMRKEAPI
121 AFVPQLGSTL LTSRDDISIS EKQIDVFSSH QPAGLMNRLM GHNMMRKDGE AHQVERRAMF
181 PTVSPKTVKG YWTALFQAHA DRIIDAIEPG RIDFMRDFAL PFSGECLKSI TGLTNIGFAE
241 MDAWSQGMIE GIANYVGDPA VEARCHAATS GIDAAIDDML PVMRKNPDQS ILGVLLASGM
301 PMESVRANVK LAISGGQNEP RKAIAGTVWA LMTHPEQLDL VRRGEVTWLQ AFEEYARWIS
361 PIGMSPRRIA KPWSIRDVAF ELDERVFLMF GSANRDEKHF ERADQFDVRR DTSKSVAFGA
421 GPHFCAGAWA SRAMIADVAL PTLFARAGRI EIADDEPVRI GGWAFRGLQN LPARWLH

>CYP194A1   Bradyrhizobium japonicum USDA 110 GenPept BAC48170        
1 MSDVSEPVAH PPVTDWVNDF DHTDPQWTDD PFPIWDELRA ASPVVHTERF LGCYMPTTYE
 61 AVREIANDTE HFSSRRIIVR DVRPEIARNA APPITSDPPV HKPAKQLLLP PFTPDAMKKL
121 EPRVRTICNE LIDGFISDGK VDAAARYSKY IPVRAIAHML GIPESDSDLF VNWIHMILEL
181 GIKDETMLLQ AVQEMSAYFR THIEERRSRP TDDLISYLMN AKDKEGQPLE ESHVLGSLRL
241 LLIAGIDTTW SAIGSSLWHL ARTPADRERL IAEPGLIPIA VEELLRAYSP VTMAREVVKE
301 TTISGCPVKA GNMVLLSFPA ANRDPKMFPD ADKVVIDRRE NRHAAFGLGI HRCVGSNLAR
361 MEMQVALEEW LKRIPDFRLD PAGTVTWSQG TVRGPRQLPF LLGKAM

>CYP194A2   Rhodopseudomonas palustris NZ_AAAF01000001 gene = Rpal3007
MSERAPVTDWVNDFDHTDPRWTENPYPIWDELRSAGPLVHTDRF
LGCYMPTTFAAVKEISYDTDHFSSRRVIVRNVRSESPPPAPPITSDPPEHKPAKRLLL
PPFTPDAVAKLEPRVRAICNELIDAFIEDEGCDAATAYTKHIPVKTICHMLGIPEDDS
DIFIRWIHEILELGINDDAILMKAVFEMSTYFQGHIAHRKQKPTDDLISTLMNARDDK
GQPLSDAHVLGSLRLLLIAGIDTTWSAIGAALWHLATHPADRERLLAEPELMPTAIEE
FLRAYSPVTMAREVMKETSIAGCPVKPGNMVLLSFPAANRDPSVFPEADRVMIDRKEN
PHVAFGLGIHRCVGSNLARMEMTVAIEEWLKRIASFRLDPSQKVRWSEGTVRGPRSLP
LLFGKPS

>CYP195A1   Bradyrhizobium japonicum USDA 110 GenPept BAC48121     
1 MNADAKELAA SFDLEKLTPE FYDNPYPTYR ALRENEPVKR LPNGTVFLTR YDDLVTTYKN
 61 TKSFSSDKKR EFAPKYGNTP LYEHHTTSLV FNDPPAHTRV RRLIMGALSP RAIAGMEADL
121 IKLVDGLLDA IAAKGSCELI EDFAASIPIE VIGNLLDVPH DERTPLRDWS LAILGALEPV
181 VSPEAAARGN KAVKDFLSYL ETLVARRRGK PGNPERDVLT RLIQGEGNGE ENGERLTEKE
241 LLHNCIFLLN AGHETTTNLI GNGLVALDRH PDQKQRLIDH PDMIKTAVEE MLRYESSNQL
301 GNRMTTERVE LGGVMLDAGT SVTLCIGAAN RDPAQFPDPE SFDIARTPNR HLAFATGAHQ
361 CAGMALARLE VAIAISRFLA RFPNYAVNGR PVRGGRVRFR GFLSVPCAIG

>CYP195A2   Rhodopseudomonas palustris NZ_AAAF01000001 gene = Rpal0264
MSVEEAALAAGPGPPTGRMTCVAPVPAARPDPQISRPFRQRRKS
PIDVKNGNDMETAPAELAEAFDLARLTPDFYDNPYPTYHALRAHQPVKRLASGGYFLT
RYDDLVAVYKNTTLFSSDKKREFTPKYGDSLLFEHHTTSLVFNDPPSHTRVRRLIMGA
LTPRAIAGMEPDLIALVDRLLDAMAAKGRVDLIEDFASAIPIEVIGNLLGVPHDERGP
LRGWSLAILGALEPVIGPEAFALGNAAVAEFLGYLDTLIARRTAEPGDPERDVLTRLI
RGEAGGEKLTAKELLHNCIFLLNAGHETTTNLIGNGLVTLAANPDQKRRLIAEPALIK
TAVEEILRYESSNQLGNRITTAEVEIGGVSMPANTSLTLCIGAANRDPAQFADPDRFD
VSRSPNRHLAFASGPHQCAGMALARLEGAIALSRFLAHFPDYVLDGPPQRGGRVRFRG
YLGVPCRLG

>CYP195A3   Burkholderia fungorum GenEMBL NZ_AAAJ02000119 64% to 195A2
MGAAIDVEVGALGDACIGNPDRVGVDDAGVRTARQRNERFVMVG
GKGRGALNDEVHGRRRSDTVEGGRAARAANPAIVTVRRFASPRAIRAKRCCARHPAWR
RAILRRAVHTDESNDASQPPRTPTVACTPSRRAKSGTRTQRHPRRGAPLRRHRMTPAT
ASDASTLARDFDLRHLNPAFHADPYPVYHALRAHEPVKRMPDGSLFLTRFRDVQAVYR
DPKTFSSDKTVEFKPKYGDSPLYAHHTTSLVFNDPPRHTRVRKLIAGALTARAIAAME
PGLVRLVDGLLDAAAARGRIDLIDEFASAIPVEVIGNLLDVPHTERAPLRDWSLAILG
ALEPSLSEAQLERGNRAVSEFIDYLRDLVARRRREPGDPQHDVLTRLIQGEAGGEQLS
EAELLQNCIFILNAGHETTTNLIGNGLVTLTQWPEQRAALLHEPSLIESAVEECLRFE
SSNQLGNRMATVDTEIGGVAVARGTPVTLCIGAANRDPEQFADPDRFDIRRDPNRHLA
FGFGIHQCAGLSLARLEARIAIGRFVQRFPAYRVNGEPTRGGRVRFRGFAAVPVELEP
AGRRTA

>CYP195A4   Stigmatella aurantiaca GenEMBL AJ421825 complement(4978..6231)
MLRSVSASRPPSPANPVAAFDLARLDDAFYADPFPLYRAMRERD
PVHRMPDGSLFLTRWADLDCIYRDTRTFSSDKRAEFGAKYGDAPLFEHHTTSLVFNDP
PLHTRVRRLIVGALTPRALSTMEPGLRTLVDRLLDGLAVKGAADLIEDFAAAIPIEVI
GNLLDIPTEERGPLRGWSLAILGALEPRLTAEQEACGNEAVTEFLDYLRILVAQRRAR
PGDPATDVLTRLIQGESDGERLTETELLHQCVFLLNAGHETTTNLIGNALELLARFPD
ERARLLRAPALIPTAVEEVLRYESSNQLGNRRVAEDTEIGGVAVPTGTFLTLCIGAAN
RDPARFEDPEHFDVGRQPNRHLAFAGGAHTCAGMNLARIEARIALAAFLARFPDYALT
APPVRARRARFRGFTAMPTRLGSLR

>CYP196A1   Bradyrhizobium japonicum USDA 110 GenPept BAC46159     
1 MLPRSAGAGR NKVAVARCPF GQPTGALVMS MQNVAAPALQ FTAPRRNELT HIPGDEGWPV
 61 IGKTFQVLAD PKGHIEANGA KYGPVYRTHV FGETNVVLLG PEANELVMFD QQKLFSSTHG
121 WNKVLGLLFP RGLMLLDFDE HRLHRKALSV AFKSGPMKSY LSDLDRGISA RVAQWKAKPG
181 EMQLYPAMKQ LTLDLAAASF LGADIGPEVD EINRAFVDMV AAAVAPIRRP LPGTQMARGV
241 AGRKRIVAYF RQQIPLRRGN HGGDDLFSQL CRATHEDGAL LSEQDIIDHM SFLMMAAHDT
301 LTSSLTSFIG ELAANPDWQD RLRAEVLALG LAPGAPSSFD DLEKMPLSEM AFKEALRIKP
361 PVPSMPRRAM RDFTFKGFRI PAGTAVGVNP LYTHHMKDIW PEPDRFDPLR FTEEAQRNRH
421 RFAWVPFGGG AHMCLGLHFA YMQAKCFARH FLQNIEVSLA PGYKPDWQMW PIPKPRDGLK
481 VRVKAV

>CYP196A2   Rhodopseudomonas palustris NZ_AAAF01000001 gene = Rpal2059
MSIQVADSSLVARLSPPKPSALAHVPGDEGWPIIGRTLAVLADP
KGEVEKMARTYGPVYRSRVLGETSITLLGPEANELVLFDNTKLFSSTHGWGPILGRLF
PRGLMMLDFDEHRLHRRTLSVAFKAGPMQSYLAELNAGIAHRVAEWRARPGEMLCYPA
MKQLTLDLAATSFLGTAIGAETEEVNRAFIDMVAASVAPIRKPWPGTAMARGVKGRQR
IVAYFAEQIPIRRAKGGDDLFSQLCRATHDDGALLSNQAIIDHMSFLMMAAHDTLTSS
LTSFVAALAAHPEWQQKLREEIAGLGLKPGEPISFEQLDALPLTEMAFKEAMRLRPPV
PSLPRRATRAFSFKGYTIPAGTMVAVNPLFTHHMPEIWPNPDQFDPLRFTDEASRGRH
RFAWIPYGGGAHMCLGLNFAYMQAKCFAVHLLQHLDLSLPPNYQASWQMWPIPKPKDG
LRVNVAPLN

>CYP196A3   Novosphingobium aromaticivorans NZ_AAAV01000177 gene = Saro3719
MASIAPDSRTDLHTERANPHWVRLGGDHKLDHVPGEDGWPVLGT
TLMQLADPLGFQRRMVETHGPVFRTRSFGRRGVNLIGADANELVLFDRDRLFSNEQGW
GPVLNLLFPRGLMLMDFEAHRVDRRALSIAFKPEPMRAYCSVLNTGIAQAVQGWGGQM
RFYDAIKALTLDTAASSFLGLPLGPEADRLNKAFVDMVQASGGVVRRPLPFTRMGKGV
AGRRLMVEYFGRLVRERRADPGQDMFSQFALATREDGSLLPEDVVVDHMIFLMMAAHD
TITSSATVLFWQLARNPDWQDRLRAEARAVTGGDGLPLAYEDLGRMELTEMAFKEALR
FMPPVPNMPRRALRDFEFGGYRIPAGTPVGISPAAVHADPAHWPEPDRFDPLRFTPEN
VSGRHKYAWVPFGGGAHMCLGLHFAYMQVKLLVSHILTRYEVAMQPGPAPSWQAWPIP
KPRDGLRVEMRRIC

>CYP197A1   Bacillus halodurans  GenPept BAB04298     
1 MPTNTMPTGP KGNPVLGNTI EFGKDPLQFI TRCSQEYGEI VRLRFERERD TFLLNDPKHI
 61 QYVFMNKGGE FSKGYQQDPI MGLVFGNGLL TSEGSFWLRQ RRLSQPAFHP KRIADYADTM
121 VGYCERMLNT WMDNDTRDIN DEMMQLTMAI ATKTLFDLDL HKGDTQEASR SLDTVMTAFN
181 EQMTNVFRHV LHLIGLGKLV PPVSRELREA VESLDKMIYS IIEERRKHPG DRGDLLSMLI
241 STYDEDDGSY MTDRQLRDEI ITLFLAGHET TANTLSWAFY LLSQHPHVEE KLYQEVSQVL
301 GNRPATLEDM PKLSYAEHVI KETLRVQPTV WLISRRAEKD VTLGDYHISA GSEIMISQWG
361 MHRNPRYFND PLTFLPERWD NNDNKPSKYV YFPFGGGPRV CIGERFALME ATLIMATIVR
421 EFRMELVDEL PIKMEPSITL RPKHGVTMKL RKR

>CYP197B1   Nostoc punctiforme NZ_AAAY02000014 gene = Npun5259
MVADVFELPAPSVNSIVGHLFELGQDPLGFLTRCRDYGDIVPLQ
LGLTPSCLIINPEYIEEVLKNRNDFIKSRGLRALKSLLGEGLLSAEGESWFWQRRLAQ
PVFHQKRINGYSQTMVEYTNRMVQTWHDGETHDIHEDMMRLTLQIVMKCIFSDDIDAG
EAKVVADALDVAMQWFESKRRQNFLVWEWFPRPENIRYRDAIAQMDEAIYKLIQERRN
GGEKTNDLLTMLMEAKDEQTLQQMDDKLLRDEVATLMLAGHETTANTLSWTWMLLAQN
PGVREKLESELNQVLQGKLPTLEDLGQLVYTQQIIKESMRLYPPVPLMGREAAVDTQI
GDYEIPQGMAIMISQWVMHRHPKYFENPEAFQPERWTQEFEKQLPKGVYIPFGDGPRI
CIGKGFAQMEAALLLATIAQRFQIDLVPGYPIVPQPSITLRPENGLKVQLKQIALDTS
K

>CYP198A1 Xanthomonas campestris pv. Campestris str. ATCC 33913 GenPept AAM42184          
1 MRRPAFPASV MNSSGAVWQH KRRTLMPAFR AALVRESAMQ ASAATRSLLH ELGDSCATQD
 61 MRTLMTGLCA QLGAGFLLGD SANAADLLRM LPMVDAISKQ TRRQSLAPTW WPSSGRRRLR
121 RLRADIDMAL DRILMQSTQR PPRAASVLAL LLAETARDDG DWCRDEAAAI LMSALEPMSA
181 ALTWTLLLLA QHPHIAQEVA QEASALDGAD VASGTSLLDR LPQSRACVKE SMRLYPPAWI
241 TARIAQRDAT LNGFHVPRGT QLLVSAWVVH RDGRHFPDPE IFLPARWLDD SATHSLTRYS
301 YFPFGGGPRS CIGCMLALTQ MTIVIATVLH ACSLHLAPDA RPSPFPALVL RPMDVRIALR
361 PRVIRSVVPS RAHASPVRLA SVTPND

>CYP199A1   Bradyrhizobium japonicum USDA 110 GenPept BAC46313        
1 MSAPGSAASG VPHLDVDPFD MNFFADPYAA HELLREAGPV VYLDKWNVYG VARYAEVHAV
 61 LNDPATFCSS RGVGLSDFKK ETPWRPPSLI LEADPPAHTR TRAVLSKVLS PTVMKQVRDR
121 FAAAAEERVD ALIEKRSFDA IADLAEAYPL SIFPDALGLK SEGREHLIPY ASVVFNAFGP
181 PNQLRQEAIA RSTPHQAYVA EQCQRENLAP GGFGACIHAQ VDEGAITASE APLLVRSLLS
241 AGLDTTVNGI GAAVYCLARF PEQWQRLRGD LSLARSAFEE AVRFESPVQT FFRTTTREVE
301 LSGATIGEGE KVLMFLAAAN RDPRRWDKPD SYDVTRRSSG HVGFGSGIHM CVGQLVARLE
361 GEVMLTALAR RIAKIEITGE PKRRFNNTLR GLDGLPVTIT PA

>CYP199A2   Rhodopseudomonas palustris NZ_AAAF01000001 gene = Rpal3146
MRPSGLGAAAADRRDFGGRDAPVMGMSAANACADIRTCHGISQV
AIEEDNMTTAPSLVPVTTPSQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPVVYL
DKWNVYGVARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRT
RAVLSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVFPDAMG
LKQEGRENLLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGAC
IHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSLA
RNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRY
DITRKTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNTLR
GLESLPIQLTPA

>CYP200A1   Bradyrhizobium japonicum USDA 110 GenPept BAC49097        
1 MAPRLDFTSE AFFRDPPAAI AALRASGPVV ATRFPLVGDV WITTTHDATA EVLKDGTTFT
 61 LRKEDGKVAG LRWWMPKLVT TIANNMLTMD EPDHTRLRSI VDEAFRRRAI VAMEPRIRAI
121 ADGLANDLFA DGSPADLVQC YARILPVSVI CELLGLPAAD RPRFIAWANK MSSLTNVVSF
181 FRLLFAFRKM RAYLERQLQI ARVRGGEGLI AELVQVELEG GQITPDEMVS MVFLLLAAGS
241 ETTTHLISGS VYELLRNPAL RDWLEEDWSR ISLAVEEFLR FVSPVQFSKP RYLRRDVELA
301 GVRLKKGDRV MVMLAAANMD PAVHDRPERL DLTRKPNRHM SFGTGIHFCL GHQLARIEAT
361 CALQALLARW PKLELAVDPA QIHWRKRPGM RAIARLPVVA GGNRRPSRGA AAEPLLAD

>CYP201A1   Bradyrhizobium japonicum USDA 110 GenPept BAC45822           
1 MNIASVRRPI VPPTPPRAPD DMSFLGRVAV IRQNMIATWG QRAYEEDVLE GRFFLHKSFI
 61 LNRPDAIRHV LLSNYENYTR TPAGIRMLRP VLGEGLLIAE GHAWTFQRRT LAPAFTPRAT
121 ANLVPHMTAV LDETIAKLDA RSGETVDLRE TMQRMTLEIA GRTMFSFGMD RHGPTLRNFV
181 VEYGERLGRP YFLDMLLPVS WPSPMDFARA RFRKRWTEFV AMLIAERRAA GKKDGAPPRD
241 LFDLMDEARD PETGKGFSDE QLIDEVATMI LAGHETTATA LFWALYLLAL DPDTQEEVAS
301 ETRGEHLDSM ADIDRQKFTR AVIEETMRLY PPAFLIARAA RAKDNAAGIE IGRGDIIMIA
361 PWLLHRHEKL WDQPNAFVPK RFMSTEAPDR FAYLPFGAGP RVCVGAPFAQ AESVLALARL
421 IGAFRVELVD TVPVIPHGVV TTQPDRSPMF RITRR

>CYP201A2   Rhodopseudomonas palustris NZ_AAAF01000001 gene = Rpal1705
MGSAGAFSLPVSHTTFVEQQRGSGFEVSIAAIDDRPASRAPLIP
PTPPRAPENLSALGRLAAIRHNAIASWGDRAYQDDVVRGRFFAHSSYILNTPDAIRHV
LVDNTDNYRRTATGIRVLRPMLGEGLLLAEGRAWKHQRRTLAPAFTPRAVATLVPHMA
SATDEVVEGLRRKTGVPLDLRETMQHLALEIAGRTMFSFEMGTHGQALRGFVIDYGTR
LASPRFLDLLLPLGWPTPQDVSRALFRRRWTRFIGELIAARRAAGKAEGAPPRDLFEL
MLAARDPETGEAFSDAQLGDQVATMILAGHETTATALFWALYLLALDPDAQERLANEV
RRVGFGGTEIERLPFTRAVLDETLRLYPPAFLIVREAAGPDRVAGFAVRKHDVMLIAP
WLLHRHDKLWSDPNAFVPERFLPGVPSPDRFAYLPFGVGPRVCIGAHFALVEATLALA
KIVGTFRIELIDTEPVIPIGVVTTQPDRSPLFRLTPR

>CYP201A3   Magnetospirillum magnetotacticum GenEMBL NZ_AAAP01000877 60% to 201A2 
675 LILAGHETTAV 643
640 PLLWACTLLALSPETQERVAAESGQADKPFTRAVIDETVRLYPPAFVLARR 488
487 AAGVDTLGGETVQPGDSVTISPWLLHRHRRLWRDPDAFDPGRFLPGASPVPRFAYLPF 314
313 GAGPRVCIGAAFALTEATLALSRIVGRFRLARADARPVLP 194
    AAVVTTQPDHAPAFRLTLRT* 131

>CYP202A1   Sinorhizobium meliloti GenPept CAC45831                 
1 MSIAPGITID GPARRVSLDV RNPRFFRNPL PAYAALHAQC PAFFWEEPQQ WFFAGYEQVN
 61 SLLRDRRFGR QILHVATREE LGMPEPKPHL KDFDALEAHS LLELEPPAHT RLRTLVNRAF
121 VSRQIEELRP EIEALSHAVI DGFEKDGETE LLKTYAETIP VTIIARMLGI PVEAAPRLLD
181 WSHRMVKMYV FNPSLETEFD ANNASAEFAD YLKGIIAEKR TNPADDLLTH MITSEKDGER
241 LSDAELISTT VLLLNAGHEA TVHQIGNAVR TILQSGLSPA ELFSDEKATE RTVEECLRFA
301 APLHIFQRYA LMDIELENGI ALRKGDKIGL MLGAANVDPR KFSSPDTFRP DRNEGANVSF
361 GAGLHFCIGA PLARLELQIS LPILFRRLPG MRLKNEPPVK DAFHFHGLER LDLVW

>CYP202A2   Mesorhizobium loti GenPept NP_108561                
1 MTNSTLPYLA FDPATRRLRL DPHEPAFFLN PYEAYGFLHD VSNAFFWEEF GFWCFGGFDD
 61 VNRLLRDRRF GRQNPAGIPD SRGVGQDRSH LRAFDGIEAN SMLELEPPVH TRLRTLVNRA
121 FVSRQVERLR PRVEALANEL IDRFDPTGPV DLLPAFASPL PITIIAEMLG VPVEMGPQLL
181 DWSHQMVAMY IHGRTRETEE TANRAASEFA DFLRGYVAER RRNPGDDLLS LLISAQEDGE
241 RLSEDEMVSS AILLLNAGHE ATVHQTGNAV RSILAQGGDP SRFFTSAEAT AATVEECLRF
301 DAPLHMFMRY AYQEIEIAPG IVVRPGQTIG LLLGMANHDP RAFAEPQAFR PDRADQKNVS
361 FGAGIHFCIG APLARLELQV SLKTLFERHP RLHLAEQSRF RDTYHFHGLE TLAVGF

>CYP202A3   Agrobacterium tumefaciens NC_003062 complement(1243027..1244274)
MTATFPFLKIDPATRRVSLNARDPAFYNDPNPVYAALHAQCPTF
YWEEQRQWFFTCYDHVSTLLRDRRFGRQILHVASREEIGLPEPLEHVKHFDLAEQHSL
LELEPPEHTRLRTLINRAFVSRHVDKMKPEIEELANRLIEAFEANGETELLSSYADII
PVTMIARMIGIPEEMGPQLLKWSHAYVGMYMFKRTPEDELLADKAAQEFSDYVRRVIA
ERRAEPKDDLLSHMIHTEHKGQYLTDDELVSTTIVLLNAGHEATVHQIGNSVRIILES
GLDPKTLFHDETATERTVEETLRICAPVHIFQRWVLEPVEIDGVQFKRGDKVSLILAA
ANLDPAKFSDPLAFQPDRNEGANVSFGAGIHFCIGAPLARLELNLALPLLFKRLPGLK
IAEPPKVKDVYHFHGLERLDLAW

>CYP202B1   Rhodobacter sphaeroides GenEMBL NZ_AAAE01000131 48% to 202A2
MQTLSQSPHDRRFLRNPYRFYREARAAGPFFHWEELGLVCTTSY
AAANAILRDRRFGREVPPGRASAVPDHLAPFAAVEAHSMLELEPPRHTRLRNLVLRAF
TSRRIGTMQPEVAALSESLVAAVPEGPFDLLPAFSQRLPITLIARLIGIPESLAPELL
RWSSAMVAMYQAGRTRKTEERAALAAADFSDFLRLHIEARRHAPADDLLTHLIAAEAD
GQQLSTDEIVSTCILILNAGHEAAVHAIGNAAAVLLRHRTPPEALAPPHLLGTVEELL
RFDPPLHLFRRMAYERVEIMGRTIEEGCEVALLLGAANRDPGPWERPDRFLWNRPEKT
HLAFGAGLHFCLGAPLARLELATALPILFGRLPNLQLVKPPSYGDSWHFRGLERLIVSA

>CYP203A1   Rhodopseudomonas palustris NZ_AAAF01000001 gene = Rpal2284
MFSFDPYSPIVDADPFPLYKTLRDEYPVFWSEPAQMWILSRYLD
VAGAGSNWQVFSSAKGNLMTELPNRAGATLGTTDPPRHDRLRGLVQHAFMKRNLEALA
EPMREIARDAAEALRGRDQFDFISDFSSKFTVRVLFAALGLPMGDEQTVRDKAVLMVQ
SDPVTRAKGPEHLAAYAWMQDYASSVIAQRRAEPKNDLISHFSMAEIDGDRLDEREVL
LTTTTLIMAGIESLGGFMSMLALNLADFADARRAVVADPALLPDAVEESLRYNTSAQR
FKRCLQSDLTLHGVTMKAGDFVCLAYGSANRDERQFPNPDVYDVKRKPKGHLGFGGGV
HACLGSAIARMAIRIAFDEFHKVVPDYTRTEQQLNWMPSSTFRSPLRLDFAVEQAASR
SAA

>CYP203A2   Novosphingobium aromaticivorans GenEMBL NZ_AAAV01000114 62% to 203A1
MATVIERPQFRFDPYSPAIDADPFPAYKVLRDEYPCFWSEEAGK
WVLSRYDDVLAALQDWRTYSSAKGNLVDEFPGRAGSTLGSSDPPRHDRLRALIQSAVT
KRALEHIIAPARASAQAHLAALADKPVFDLVGDYTSKLTVDLLFYLFALPDEGAQQVR
ENAVLMVQTDPVTRQKSPEHLAAFHWMADYAEKLVASRKANPGDDLLSSFITAEIDGE
KLLDKEVQLTVTTLIMAGIESLSGFMAMFGLNLADYPEARSALVADPSLIPDAIEESL
RFNTSAQRFKRTLTRDVELHGQVMKAGDAVILAYGSANRDERMFENPDVYDITRKPRR
HLGFGGGVHACLGSMIGRLATQIAYEELLKAVPDFRRADAPLDWVPSSNFRSPKSLML
EKKA

>CYP204A1   Novosphingobium aromaticivorans NZ_AAAV01000167 gene = Saro2888
MARAATAAGNGLPLLDGGVPLLGHLAQFFRDPVSVLKRGYRSKG
RLFAMNFMGQRMNVMLGPEHNRFFFEETDKLLSIRESMPFFLKMFSPEFYSFAEMDEY
LRQRSIIMPRFKAASMKQYVPVMVEESLNLVERLGEEGEFDLIPTLGPVVMDIAAHSF
MGREFHEKLGHEFFELFRDFSGGMEFVLPLWLPTPKMVKSQRAKRKLHAILQSWIDKR
RAAPLDPPDFFQTMIETKYPDGRPVPDEIIRHLILLLVWAGHETTAGQVSWALADLLQ
NPDYQKVLRGEISSLLGGSDGRDLGWEQAVAMEKMDLALRETERLHPVAYMLSRKARA
DIERDGYVIRKGEFVLLAPSVSHRMEETFRNPDAYDPERFNPANPDAQIESNSLIGFG
GGVHRCAGVNFARMEMKVLVAILLQNFDMELMDEVRPIAGASTYWPAQPCRVRYRRRK
LDGSEAGADMAALARAAGCPAHT

>CYP205A1   Chloroflexus aurantiacus NZ_AAAH01000322 gene="Chlo2055"
MIPAIPVLIGDTAMIRFPSPVAIRNLQQLRREPLTLLEELAARG
DVVPFRVGPQMMVLVNHPDLIREVLVTQHRSFVKGRVLERAKRLLGEGLLTSEGELHL
RQRRLMQPAFHRQRIAAYGDAMVAVAEARSARWQDGLVLDVSREFMAITLQIVGITLF
SADTEADADEVFAAMHDLVAMFDLAVLPFADWLFALPLPPVRRFQAVKARLDAIIYRL
IAQRRANPVDRGDLLSMLLTAVDHEGDGYRMTDTQLRDELLTIFLAGHETTANALTWA
LYLLAQYPSLAAHLAAELDTVLGGRKPTVADLPKLTYTSWFFAEALRLYPPAWLIGRR
AIAPVTLGDVRIAPDTIVLLSPWLMHHDPRFFHEPYHCDPLRHTPEAQAQRPKFAFFP
FGGGPRTCIGEPFAWMEGILVLATLAQRWQFLPVADHPVVLQTGITLRPRYGMQLQLR
ERRTVLGAA

>CYP206A1   Agrobacterium tumefaciens (strain C58, Cereon) GenPept H97549
1 MTEIGFRTPS TDTTGAQPVS KLATARLALS LIRNPLKALP PEIFSEPAVF TRLGGVMRVH
 61 LADPVLIHEA LVKNAALLGK GEDVRRALGP ALGQGLLTAD GDHWKWQRQS VAAAFRHEKL
121 LELLPVMIET ARRTQKRWRS SSTADIDIGH EMMRTTFDII VETMMSGGYG IDIARVEQSI
181 TDYLKPTGWT FALAMLGAPE WLPHPGRRKS RAAVDYLRAS LATVITGRRK NPTDRPDLVS
241 MLLEAKDPET GRMMSDEEII DNLLTFITAG HETTALGLAW TFHLLSQNPE TERKAVEEIE
301 AVTGGEPVAA EHIANLAYVR QVFSEAMRLY PPAPVITRTA LQDFRLGEHD IPAGTVLYVP
361 IYAVHRHTAL WDEPERFDPS RFEPEKVKAR HRYAYMPFGA GPRVCIGNAF AMMEAVAILA
421 VILQKNHLEN RTMASAEPLM RVTLRPQERL MMKITQRQNK SPAV



>CYP207A1   Kitasatospora griseola GenPept BAB39208  
1 MKGNLPAMST ATSSSVTGSV TTPRTATTPG RRPGLAPGGV PVLGHLPMIL RSRFEFIETV
 61 RNAGPVTRVK LGPKTAYFVN DYELLAQILV SDADKFVRGI HFKKMRNMVG NGVVTTSGDL
121 HRRQRRIMLP SFSQRRLAMH LPVMRKIMSE FVASVPERRP YDLMGPVMGV GCDIVTSTML
181 GEKTPPEVLR LVREAVPVFV ENAAIQAVDV TGIYKHLPTK SNRDFERLLN AFNEYMYSVI
241 DDKFRNGAGE EAGLLDMLIN ATDPETGEKF DRTEVRDQAA TILLASTETT ANTISWACYE
301 LARHPRIFAE CRAEIDALVK DRDWLDIEIG RHDLPALKRV LFEALRMYPS SYLLSRQASV
361 DTTLGGYAIP KDAAILYSHY GQQRDERNFP HGDEFDPDRW LDKDGAEVTA SAFMPFGFGA
421 YRCLGESVAV LEATYCLAMM VHQWDFALSD YSEPKMNATI TLSPKDLEFL FTKRTESGAH
481 DE

>CYP208A1   Streptomyces globisporus GenPept AAL06697  
1 MRIDPPGPPL RALPGLLRKL AVDRLGMMRD AAGLGDAVRV SMGPKKLYIF NRPDYAKHVL
 61 ADNSDNYHKG IGLVQSRRVL GDGLLTSDGE TWREQRRIVQ PAFKPGRINQ QAAAVAEEAA
121 KLVALLRGHE GGGPVDVLQE VTGLTLGVLG RTLLDSNLTA HESLAHSFEE VQDQAMLEMV
181 SQGTVPAWLP LPPQARFRRA RRELYRVADL LVADRRSRMA DGGPGDDALS RIIVAADRRR
241 DDPARARNRL REELVTLLLA GHETTASTLG WTLHLLERHP EVRDRVRAEA RAALGDGVPG
301 PEDLHRLTYT TMVVQEAMRL FPPVWILPRV AQQRDVVGGY TVSAGSDVLV CPYIMHRHPG
361 LWEDPERFDP ERFEPRQTAD RPRYAYIPFG AGPRFCVGSN LGMMEAVFVT ALVTRDLDLR
421 TVAGHRAVAE PMLSLRMRGG LPMTVSTAR

>CYP208A2   Streptomyces carzinostaticus subsp. Neocarzinostaticus GenEMBL AY117439 
MNGRRPVSPPLRALPGLLRKLAVDRLGMMRDAAALDDAVLVSMG
PKKLFVFNRPDYAKHVLADNAANYRKGIGLIESRKMLGDGLLTSEGELWREQRRTVQP
AFRPARVAAQADAVAEETMNLRDLLMRRGADGPVDVLQEVTGFTLGVLGRTVLNTDLG
GYGGIAHAFEAVQDQAMFDMVTQNMVPTWAPLATQRRFRRARRELIRTVDELVADRSA
RMTDGEEADDAFSLMIAAARRQTDPRTGQGRLRDELVTLLLAGHETTASTLAWTLLLL
ARHPHMRDLVREEARGVLADGRAPDAGDLRKLTYTTQVVQEAMRLYPPVWILPRVARQ
SDEVGPYSVSAGADVLICPYTLHRHPDLWERPEQFDPGRFDPARVADRPRYAYIPFGA
GPRFCVGSNLGMMEAVFVTALLTRDLVLEVVPGDERTPEPMMSLRMRGGLPMTVRPVR

>CYP208A3   Actinomadura madurae GenEMBL AY271660 
MSIDELDARGGTPRAAGRVPPGPPRRATPNLLRMLATDRLGMMQ
AALRHGDAVRVGLGPKALYLFNRPEHAKHVLADNSGNYHKGIGLVQARRALGDGLLTS
EGDLWREQRRVVQPAFQHKRIAGLADAVVEEAGALVARLRARAGGPPVDVVGEMTALT
LGVLGRTLLDADLTAHTSLGRAFETVQDQAMFEMVSQGMVPMWLPLPGQLRFRRARRE
LDRIVRALVAERLREGGGAEDALSRLIESARREPDGRVGRRRLRDELVTLLLAGHETT
ASTLGWTFHLLDRHPLVRARVRAEARAVFGDGTPTLDDLSALSYTTMVVQEVMRMYPPVWI

>CYP209A1   Myxococcus xanthus GenPept CAB40542 
1 MGTSEPVEPD HALSKPPPVA PVGAQALPRG PAMPGIAQLM MLFLRPTEFL DRCAARYGDT
 61 FTLKIPGTPP FIQTSDPALI EVIFKGDPDL FLGGKANNGL KPVVGENSLL VLDGKRHRRD
121 RKLIMPTFLG ERMHAYGSVI RDIVNAALDR WPVGKPFAVH EETQQIMLEV ILRVIFGLED
181 ARTIAQFRHH VHQVLKLALF LFPNGEGKPA AEGFARAVGK AFPSLDVFAS LKAIDDIIYQ
241 EIQDRRSQDI SGRQDVLSLM MQSHYDDGSV MTPQELRDEL MTLLMAGHET SATIAAWCVY
301 HLCRHPDAMG KLREEIAAHT VDGVLPLAKI NELKFLDAVV KETMRITPVF SLVARVLKEP
361 QTIGGTTYPA NVVLSPNIYG THHRADLWGD PKVFRPERFL EERVNPFHYF PFGGGIRKCI
421 GTSFAYYEMK IFVSETVRRM RFDTRPGYHA KVVRRSNTLA PSQGVPIIVE SRLPS

>CYP210A1   Polyangium cellulosum GenPept CAD43453  
1 MISISKSKQK LLPPGPRSPM ALQTLQWLKN PVPFLEACGA RYGEMFTLKL PTQWPVVVVQ
 61 HPEAVKEVFA LDSNAGHAGE ANNILKPFLG KYSLLVLDGE EHMRQRKMMM PAFHGERMEA
121 YGHAMIDAAH ASIDAWPVGS PFGVHAPMQA ITLQVILRTV VGMTDGPLLA ELEALYPQVI
181 DAASAPAMHF ELFRKDLGPW SPWGKFKRRS ARGKEIMIHE IRRAREKGTA GRTDVLAMII
241 DAKDENGELL TEDEIHGELM TLLVAGHETT ATALCWALRW LLRDAALTRR VAEEAAEVAD
301 DPVKIAKSEL LDRVVKEALR LQPIGPVVAR VLKQPLTIQG RELPADVMVA PCVQLLHHRP
361 SLYPEPTRFD PDRYATFTPK PWEFIPFGGG LRKCIGAAFS MYEMKMVLAT AFSRLSMELA
421 TDDIKIIRRG VTLAPSGGLP LVIRKKSPRA TKPIAA

>CYP211A1   Streptomyces globisporus GenEMBL AY048670 
MAGLVMSPVEALDALGTVQGRQDPYPFYEAIRAHGQAVPTKPGR
FVVVGHDACDRALREPALRVQDARSYDVVFPSWRSHSSVRGFTSSMLYSNPPDHGRLR
QVVSFAFTPPKVRRMHGVIEDMTDRLLDRMARLGSGGSPVDLIAEFAARLPVAVISEM
IGFPAKDQVWFRDMASRVAVATDGFTDPGALTGADAAMDEMSAYFDDLLDRRRRTPAD
DLVTLLAEAHDGSPGRLDHDELMGTMMVLLTAGFETTSFLIGHGAMIALEQRAHAARL
RAEPDFADGYVEEILRFEPPVHVTSRWAAEDLDLLGLSVPAGSKLVLILAAANRDPGR
YPEPGRFDPDRYAPRPGGPEATRPLSFGAGGHFCLGAPLARLEARIALPRLLRRFPDL
AVSEPPVYRDRWVVRGLETFPVTLGS

>CYP212A1   Chromobacterium violaceum ATCC 12472 GenEMBL AE016919 
MKTPPQSSCPFHAVGRPPTPPRSSAGRWPPGPESGLTGWGLLKL
MSRDLMGTLAGWQREFGDLVHVRTWPEHQVIVSDPQLARELLVNQADALQRWERALTV
YRRVHGHSVLIAEGQVWREKRQALQPDFTRKSVQAFSPSIVEAARRAFEQWPARHAAW
PIESELTSVTMEVILRMMFSSGVGSEAQQAEEAVHTLMVASTEELWRPASLPDWVPWQ
RKRRRARLLMNGLIERHLQARLAMPQDAWPEDLLSRLLRLHLQQPQSWPLQAVRDECK
TAFLAGHETVATSLTWWAWCMASHPEIQERAREEALAALSGGGQADPAALQYVSQTLL
ETMRLYPAVPLLMSRRALKPVTLGDWTFPAKTVFMVPMQLMQHDERWFPEPRSYRPER
FGPDAARPQQGAYLPFGGGPRVCLGQHLAMAEMALVAAQLLLRYRLSAPEGAEPPRPV
FHVSQRPSQPLTLGIARI

>CYP212A2   Ralstonia metallidurans GenEMBL NZ_AAAI01000313 
MTVDVVSIQDSPRGSVWNLHMTTESQAQCPFQTAKSPPPAGSPL
PHPYGTWPPGPAAGLTGWHLLRRMSRDLLGTLGEWQQTYGDVVHLRMWPEHAVVVTDP
QLVRELLVTHHDSLIRWERGTRVFSRVHGHSVLTAEGDAWSRKRQALQPGFMPKAVHG
FVPGIVEIVDKGLATWPTRVADWPVESALTSLTMDVIVRMMFSDEIGEDARVAECAVR
AISEAANADFYWPASLPDWVPWKRARRRALHTLRDLIERHLQARLRMRTDTWPDDLLS
RLLCLHRDDATAWPLQAVRDECMTTFLAGHETTAATLTWWAWCMASNPSAQDAARAEV
THVLRGQAPTADSRQALRQVVQTITESMRLYPVAPVLISRRAVRPITLGPWRLPARTL
FMLPLQLMHHDPRLFPEPERFQPDRFSTGSPQAPRGAYMPFGTGPRVCLGQHLATAEM
TVIAAMLLQRYKLSVPEGAAHPRPLLNVTLRPDQPLWLAVTPI

>CYP213A1   Synechococcus sp. WH 8102 GenEMBL AABA02000001 or GenEMBL BX569692 335184..336428
1370816 MTAAPLPSTGAVTGLGETLAFFRDPSFSQRRFSELGDVFETKLLAQSIV
        FIRGERAIGDLLKQEDCLQGWWPDS
1381038 VRQLLGSKSLANRSGADHKARRRVVGQLFSSAALS
        RYTPAIEALVNDLANELQQAEGPIPLAARMRRFAFSVIA
        TTVLGLEAENRDALFADFEIWTRALFSIPLALP 1381358
1381359 GTPFARALAARQRLLARLKTVLQTNNNRQQGGLDLLSGGLDEAGLPLDDDDLVEQ 1381523
1381524 LLLLLFAGYETTASSLSCLFRALLLNPEVEQWLMQDLNNHERPSRLDATVL 1381676
1381677 EVMRMTPPVGGFFRQNTQSIELADVAIPQGRVIQVVLSSSSTTNQIDLETFRPQRHL 1381847
1381848 DGSFQQTLLPFGGGERVCLGKALAELEIRLMAMGLLQRVQLHL 1381976
        EPDQDLNLQLIPSPTPRDGLLVRATAR* 1382160

>CYP213A2   Prochlorococcus marinus str. MIT 9313 GenEMBL AAAZ02000001 
1661568 MASSDDAKLRPLPNTAALSGVLEAFAFFRDPAFAQKRFERHGNVFETSLLGQPMVFIQGGQAIRDLLA 1661771
1661772 QPNAVEGWWPESVRQLLGSHSLANRNGASHRARRRVIGQLFSASALQRYSAGIISMVQ 1661945
1661946 DLADELQAAKTALPLAERMRRFAFSVIATTVLGLEGTDRDELFVDFEIWT 1662095
1662096 RALFSIPIALPGSSFAKALKARERLLRRLQKVLLKASNGNGGLDLLAGGLDE 1662251
1662252 AGIPLTDEDMVEQLLLLLFAGYETTASSLSCLMRELLLNPQVETWLREEINGVDWPPAPE 1662431
1662432 QATTAYDQVNAPKLDAVVSEVMRLTPAVGGFFRRTKCALVIDGVEVPKNRVVQVALA 1662602
1662603 ASNRHGAGDLEAFRPQRHLEDGCSATLLPFGGGERVCLGKPLAELEIRLMVVGLFHQLR 1662779
1662780 LHLIPDQDLTLQMLPSPTPRDGLLTKVL* 1662866

>CYP214A1   Trichodesmium erythraeum IMS101 GenEMBL NZ_AABK02000024 
MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVY
QKYGPVYKTNFLGKNFIYFQGYEAIKFILTNENKYFTYSQILRNYQRIFGENDITVLA
GKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKWIKSDYVDLYSEINNYTLDMI
LKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFNQFEQIIVR
RKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTS
EHLDVLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDC
SFQGFRIPKGWHAYYYISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGG
ARECIGKEFAYLVIKIFISALLDNCSWKFKENQDLTINTFPVARPAHKIEVCFTPK

>CYP215A1   Thermobifida fusca GenEMBL AAAQ01000026 
MPAPIRIQQCPVSHTDFSTDTEIYG
HYAMLDAEREASRFRFNDTTDRGFLMIQRYDDVVEGFQHHETWTTKVRSAINPDSRSGTA
LLPQDLNGEAHAKLRRVLNPFFSPAAVRRMEPMAVARCIELIEELQPKGSCDFVAEFAIR
YPTDLFLALLGLPVSDGEFFLPWSETVFAGFFGEDPAKVAEARKNIIDYFTETIRERRAN
PRDPKEDMVTRLLEARIDGTPIPEEDILTICLTLMLAGLDTTRSALGYIYAHLARNDADR
QAIIDNPDLVPRAVEEFLRMYPLVFQVGREVQEPTEFHGLDLQPGDVVWLGIAQANRDPR
KFPEPDRFNPDRKGVNQHIAFGAGPHRCLGMHLARLELAIVLREWHQRIPHYRIREGVTL
TERGGQLTLPTLPLEWEA*

>CYP216A1   Thermobifida fusca GenEMBL NZ_AAAQ01000039a 
MTRSPSPPIRLYQAADPTALWPALLAEYGEIAPVELEPGINGWL
LLSWRLNREVMRDAETYARDPDRWADMANGRIGPRSPLRVLYGKYQSALYSDGADHKR
YRAALTAALDSLSLRQVTGHITAAADQLIDAFCLHGKADLVTQYTRQLTVTVLARLFG
LGPAETMRICLEMQAMWDEGPNAFPALMRIAEMLTELARKRRRTPGKDLASVLVAQGL
SDVEVRDNLLLIIAAADDPVTHLTGNTIRMLLTTPESRAALTTSPGLISEAVNTALWT
TPPLQTLVGRYPVRDVELAGVPIRAGECLVLGFAAASLDLAQHSDADTMSTNRAHLTW
GVGPHSCPLRGQDMALAIAETAVERLLRRLPDVALAVPPEQLRWRPSLAVRGLESLPV
RFTPTPVSNPGGTEWDSPADPTPSTSIRPKESTSPRSDANSSTKARWYAWLFPGTWKS
GL

>CYP217A1   Thermobifida fusca GenEMBL NZ_AAAQ01000029b 
MTTLAPSTDLDFYSEEVILNPYDTYRRLRDTAPAVWLERYQVWA
VTRYDDVYAALHDHRTFASGYGVALNDPLNEKMKGSALVSDPPYHDHVRGVMGGPLTP
RALRKHHDYFQERADALIDHLLELGRFDGVRDFAQIFPLSVVPDLLGWPAEGREHFLD
WASAGFQALGPMNERALRDLPTLKGMWEYMAEIVRPGRLAPGSWGAALVEAAEKGEVD
KQLLPALIGDYLVPSLDTTVSALSTMLWQLGENPDQWRMVREDPSLIPNVLNESIRYE
APIRALSRYVTEDTEIGGIPLARGSRALMVYASANRDERHRKDPDTFDVTRSNANTHV
GFGHGIHGCVGQGLARLEGHSLLNALVRKVARIEVGQPTWRVHNTIRAMTTLPVEFSA

>CYP218A1   Thermobifida fusca GenEMBL NZ_AAAQ01000042b 
MILNCEHDPVFHVPVVSTPGRWSVTHPLYPVGNSDTPHDRNAGS
SEGCPVSLDDREALHRLAVPVYGELDADLPDVLERLRKQFGRIAPVEVAPGVAAWILL
GYDVNRRVLQDSAEFARDPRRWREAREGRATPEKVPGPFWYFRNALASDDPDHSRYRP
VIVDALSGITADGTRLAVRRIATELLAPVALTGKADLVADFAFRVPLLVLNRYFGLSA
EEGLELVELMRQVWDGGEEAEKARLGLFAYAQSVTARRRENPGSDIVSRMVRHPNALD
DEEIAHQLILLISAAHDPLMNLIANTAHTLLTDEEVRYDLAGAHLRVEEVVDTVLWRS
PPITLLPGRYPVRDTLLEGAYVQEGDCLIIGYGPAHADPAVAPYIDPLSPSGIRGHLA
WGTGPHACPAQRISRQIAVDAVSALLDLLPDVRLAVPPESLERRRSLFAHGLKALPVT
FTPVDITPPTEAPWQQSQNPSSSSQENPASKPSSSVKRGRLPEWWSKVWKFGR

>CYP219A1   Novosphingobium aromaticivorans GenEMBL NZ_AAAV01000054 
MEAEAAIPPLDTSDPALIPDPWPTFTTLRERDPFHWSKYGYWVV
SRHEHVRDVLMNRKDFGTGDFAANLRLFYGPDFDVLANPAYRWLSEVFIMQDPPQHTR
IRNLVVGSLTAKRVRAMEPRIREIAQALTDGFKARGSADLITEFAYKFPVMVICDLMG
IDYEASEMADLIAAIPEAFTVFEARILSPEELALANRRILELEAFFQAQFENRLAHPR
GDLLTSLARTGQEPGGLSVHEAITVTIGLFGAGFETTANIIGNGLHALHANPEQWARL
VADPSGMASGACEEALRHQSSLIATYRTALADTSVCGHPVSAGQRVLTLIGAANRDPR
KFADPDRFDIARNDADHLTFGGGIHFCVGAELARIEARVAFEHLARELPQMQVDTGGA
CWRENFLFRGLTGLEARWPAQA

>CYP220A1   Burkholderia fungorum GenEMBL NZ_AAAJ02000117
MTFIYDPNDPDVRRDPHAVFRKLRETEPVHWSPKLSGWVVTSYE
LASEVLTTNGTYSAERFTAVQQHLSEEKRVTAAEVMRWFQHWMVFRDPPDHTRLRRHM
ANTLNIPVFDARRETVISVVNELLDRIPVGDAFDFFQAFSLWMPGIVVADLLGVERDR
LLEVKQWSDDMMTFIGSARGVPDKYERARRGANGMGTYFLDLIAKRRAEPREDALSRL
IASEVEGQRLSDDELVGCMMMVLNGGHETTANLLNNSMLALAAHPQTVQHLRQHPDEM
AAAVEEFLRYDSPVLSIGRIVTEDTELGDQEIAAGDRVFAMLVGANRDPEVFSDPDEL
RTSRNPNPHMAFGKGPHFCLGTPLARLEGQIALTAILERFSSIELCEPVESIPWLNSL
VTHGPTRLPLRLK

>CYP221A1   Pseudomonas fluorescens PfO-1 GenEMBL NZ_AAAT02000002
MSDPLLKLLQKPLFDPEKRHRVSLREYMDLNIDRMRAIIGNGLM
TNAMWLSQPRQSEFRLMLERAALIGAVDYSLLACIVDHFIAGDAFFAHGSQHQIAQYH
QEICQLKAVYAFGCTEIASGSDVANLQTTINYDPHKHCLILNSPTPQSCKFWIGNALH
AAVVVMVLGRLIVKGVDEGLHWFRVRIREQENGPLLPGVRITTCDPKGGIHANQVAGI
RFCNMKLPLDALMQRYARFSAQGVFSSEIPPKERLKSAMQTFIQERLFLIAGARGAAS
MCVYLAYRFACHRLVKGNEGSQSLLTKALFRQRLYAEQLKVLALKLLEQAVLSRFEAC
WHQPARRKELHILAAVVKSVGTWLGLEVMSACRELCGSQGFHHHNRIVTLVMDHGIST
TFAGDNNILCCQVARDAINRPRFANENIAQRIESLIVDQCRRAGDFSHRQAVALTYAR
ALDLIINEGKHHPLVTSEIFEDIVHVFSPKLYEWELVASTKLEQNATEAQLILLNELL
KPPSELVRAPIDKKNYVKHF  TKPLYDNKPDFSNRNTIRNPYRAYTWLRKHQPVYWCEH
LQAWFLTRYCDVIAAQADSRRFSSNRMQQLIDARVPENKRTHLNEFIKLASRWMYSQD
GDTHKASRHLLGNAFTPRSIEALRAIIQDITDRELSRLHGQTDLKTALFDRVPALILA
RLYGMKDDEALRLRRWTRDIVMFLGGSQDADQGPDQALEGIKEMYACFAELIEQRRRQ
PGDDLVSRVLESGQNSAASLDEVLAQIVFILVAGYTTSADQMCLGLLHLLKHPQQLEA
LLADPTLIGSFIEEMLRFDPAGSLSHRILMEDVTIDNITMKKGNLVYLIRASANRDPE
KFHAPNTFDIRRARNEHLTFGKGEHFCMGTSLFRLEAEIVFTSLLKRFPDLQLIARRP
AKWRNSNLQFRGLKTLPVDLGTGV

>CYP222A1   Thermobifida fusca GenEMBL NZ_AAAQ01000022.1 
MSLRGLPGTAPRQRAGSPGPASFLKRRRDAAPRPTISLDGDGPL
RAGLGSIPGRRLQFGAHLFVEHVGVPVFFARRKHVGRGHVAHTVPLALLSVDSDAHVA
LLRDQRSLFSLAILTLMLLSITIITRTAIKITHHTRSRHRPYPHSSQRTSAHEPGQER
AHSMSNPTRCPVIHFDHHSPEHAKDPVGAYRALRQTHKRGWTEAHGGYWVLSDYQSVF
DAARDDDLFSSTREAAGTDGLAIVIPPTPMYHHIPIEVDPPEFRKYRKIVNQVTAPAA
VERMKEMVERYTVAFVDSVIEKGECDFTTIIGVPAIVTIDWLGLPVKDWKRYADAHRA
TLAEPQDSEAFRHAVEVELPALSQQMWDTIRARRQEPKDDVISFLVSQKVDDRPITDE
EVFAMVDLLVSGGTGTTASLVSQALVWLAKNPDVRQELIDDLSLLDRAVEEFLRVFSP
TQALARTVTRDVEFHGCSMKKGDRVLLSWASANRDEEQFENPDTIDIHRWPNRHVAFG
IGVHRCAGSHLGRFMAKRLLQEILTRMPDYTIDFDALVPFHDQGTNVGFRSIPAKFTP
GKRVLPLSEAVIG

>CYP223A1   Novosphingobium aromaticivorans NZ_AAAV01000162.1
MHRAMTTTVQDFDPEVPEDFDSPHAEYARLRRECPVAHTNGLGG
FWALTRYEDVKRAASDSTTFITSVQNVVPKVAFTGRRPPLHLDPPEHTPYRKALNPLL
SLERSEAFAGKARELTRKLLAPMVENGGGDICVELSSYLPVHVFGEWMRMPEEWLDTL
HDAGRAFILAVHSNTPERMKETSLRLYDMARGLIAVRRENPQDPALDPTSALLAARHE
GEPLPEELLVGTVRQVLVVGMVAPMVMIGNICVHLSRDKALQQQLRADPSLVPAAIEE
FLRLYTPYRGFARTAVCDVDMGGRTIPKDEAIALVYASANRDEDVFPDGDKFILNRPN
IAQHLAFGRGPHNCPGVHLGRMQLRVALEEILAATREFELSGPVSVSRWPEVGALSVP
LRFV

>CYP224A1   Novosphingobium aromaticivorans NZ_AAAV01000154 
MTLLFQPSPPDHVPGERMVDFDMFHVPEGQDDPVEIWHDLVRRG
VPRIFYTPRNGGHWVFLDYADIVEAYRDHTVFSTYQTPVPPIEPFPVVQPQGVDPPAH
NVFRRLLAPMFTPTAVRGMIGELERRASELIDRFAARGECDFITEFAERFPTSTFLHL
FGLPEEQLDAFLALANVFFRSTDAETRARNIGEIYAVLDTLFREKERNPGNDIASAIV
AARDEEGRQHPWEDILNCGFLLFVAGLDTVTNTMAYIWRYLATTPAARRHFRERLDDP
DAFLRAIEELMRINAVSNLFRRVTHDCEYKGVQLRRNDRVVLPNTVANRDPRVFSDPQ
AIDLDREVNVHLTFGVGPHRCIGSVLAKREVMVSLQQWLRRIPEFELAPEQPAGSAFG
GSVMGFTALRLRWVRVEA

>CYP225A1   Novosphingobium aromaticivorans NZ_AAAV01000151 
MPSPPRLAGTSTASGLEDQMQFPFSRSTNPNVDLSSLDAFNEGA
PFATFDRMRREDPMAWSEMVNGDRGFWSVTRHADLLELNRQADLLSSAKGIRMEDQTE
EEYEARKTFQETDAPHHRGFRALVSKAFSKGTVAGFEDQIRKIVTDLLDVALAEGEFD
AVDRIARRLPMQMLAQIMGVPQEDGPWLVEKGDALISNSDPDYTDFVVDQVDTEAYRM
LPFRSPAAVELFDYANGLLDRMDAGEQIGVLNLVREPTSTGTRMSRDEFRNFFCLLVA
AGNDTTRYSISATIHALANNPHLLQALKDGDFTSWEAAADEMIRYASPTTHFRRTATR
DFTFHDRHVKAGDKVLLWFISGNRDETAILDPYTINLRRERNPFLSFGQGGPHICLGM
WLAKLEVAIVMQELAKRLSSIEQVAEHSYLRSNFIHGIKHLPVRIVAR

>CYP226A1   Burkholderia fungorum NZ_AAAJ02000018
METGMTSPAKSNALESAFESTASNYRGSDVDLNAIYRDMRRNSP
VIAQDFMASLGVPNIAKLDPNRPTFTLFKYKDVMSVLRDAANFTSGFIAEGLGSFFDG
LILTGLDGEAHRRARALLQPVFLPEVVNRWRESKMEPIVRNEFIGPMVPQRRADLMHF
GLHFPIRLIYSLIGFADDRPEQVEQYAAWALAILAGPQVDAQKAAIARKAAMEAAEAL
YAAIRSEVAVVRAKGAEGEDLISRLIRAEYEGRRLDDHDIATFVRSLLPAAGETTTRT
FGSLMTLLLERPALLERVKADRSLVSKAIDEAVRFEPVATFKVRQAAVDTGIGGVSIP
KGAMVQCIVSSANRDEEVFENSETFDIDRKPKPSFGFGFGPHMCIGQFIAKVELQVAV
NAILDLLPNLRLDPDRSPPKIVGAQLRGPDAVHVVWD

>CYP226A2   Burkholderia fungorum NZ_AAAJ02000018
MSTTLENPMLDLEAAYHAVSDTYRGPDIDLQALCREMRHKNPVM
KGDFVATHLGIPTNAGASAAKCEVTLFRYQDVLAVMRDATTFTNGFIAEGLGGFFDGL
IILAMDGDAHRRARGLLQPVFMPETVNRWRPELDRVIREDFLAPLVPNRHADLMDFGL
YFPIREMYALMGFPTDDTAKFNQYATWALAMVAGNQIDPGKIRIFGPIAAAAVKHLYD
AVMEVVLQRRAAGADGNDLISRLMRAEYEGHKLDDHEVTTFVRSLLPAAGETTTRTFS
SVITLLLERPALVERVRNDRSLIPRLIDEAVRYEPVATFKVRQAARDIEIGGVKVRSG
GLVQCMVMSANRDEDVFENADTFDIDRKPKPSFGFGFGAHMCIGQFVAKIELQCAVNA
ILDLFPNVRLDPARPAPKIAGAQLRGAKSVPVIWD

>CYP226A3   Pseudomonas diterpeniphila GenEMBL AF274704 7700..8974
MSGPAHSNLEQVFANVASNYRGADVDLHAVYREMREKSPVLPEN
FMARLGVPSIAGLDPNRPTFTLFKYDDVMAVMRDATNFTSGFIAEGLGSFFDGLILTA
MDGEAHKNIRSLLQPVFMPETVNRWKETKIDRVIREEYLRPMVASKRADIMEFALYFP
IRVIYSLIGFPEDRPEEIEQYAAWALAILAGPQVDPEKAAAARGAAMEAAQALYDVVK
VVVAQRRAEGATGDDLICRLIRAEYEGRSLDDHEITTFVRSLLPAASETTTRTFGTLM
TLLLERPELLARIREDRSLVGKAIDEAVRYEPVATFKVRQAAKDVEIRGVAIPKGAMV
SCIVTSANRDEDAFENADTFDIDRRAKPSFGFGFGPHMCIGQFVAKTEINCALNAILD
LMPNIRLDPDKPAPEIIGAQLRGPHHVHVIWD

>CYP227A1   Nostoc punctiforme GenEMBL NZ_AAAY02000109 21775..23139
MTVNIMTLKDKVLKGQDRQLWLAPILAKVGYDTAIGKFLRLIFY
YTDASIILKAWRDFLYIRKDNIGDKYFAVDQAIMHSSHSQVRELMQTQPQLRGNDLGI
IRILAPSYLLDNPLSLGTNGNEHTGLRTVILQALPEPSQKIDFLGNLVEQSLLEAAKQ
GKLHIGNDLPKIILSILHQLVFQISLSEEEITASDSYIKGLALASLPNFINKYLLAIL
TAPKIRHRQYLTNRYKQSAKWASYFETGAQYQLNEHQIANTLFDMIHIAGTAGTSALL
GSVIGVLCLDNDLRNDVVSEVNAVWNGKKTLDPDALEQLTILNQVILETARLYPPVRF
VSQLTNEGGEVEIGEQKCPFQKGTRLLGSIFTANRDANRYQNPNDFDLTRNFSDILSW
NGEGHERACPGKSLSIGFIKIFCLHLFQNYQWDSITEVKWDFEKVTAVTPNNLVLQGF
AQRL

>CYP228A1   Magnetospirillum magnetotacticum GenEMBL NZ_AAAP01002937 
MGPRPHARLVRRPPLPARARGHPVTGTALAPAPAGLAAAMRWEE
RVQRGAHPLVYPAIRALRHRGPVVRVPGIGVVVSDAATARAVLLDTEHFSKVGPGSPS
DLWTPVLGPSVLLNMEGADHARLRRALSGLFTPRAVRDLVAVSVPDVLAGLAPRLLAG
ERVDLVAETATMAGTVVCAMTGLPPTDSAVREAMTAAQSVVGLVRLHRRSLTPSQVRH
ARAVLARLSAPARDAYRAGDPATVPGRMRELGLSEDEALGAVGAFVLTGTETIQSFVP
RLVALTADTGWLDRLLAADPGAGPEAAALRGRVVEEALRVTAPTPAMLRSVRAATTVG
DVRVRAGDRVVIATISCCKDAGPFDPDAPVDPAVRHLWFGAGPHFCLGMPLATAQVDA
VLDALRPVAAAGRSLQVTDRAVARGVLIPAYRSLV

>CYP229A1   Pseudomonas fluorescens PfO-1 GenEMBL NZ_AAAT02000063 
MDPIIAATHADPYPYYAELRAAGGLTFHHGLKLWVASSARAVCA
VLAHPDCRVRPVQEPVPKAIVDGMAGKVFGLLMRMNDGEAQRCPRSAIEPPLGLIDRE
EVGALVSARLITNDSDGLYKAMFRGPVCVVASLLGFTPAQARVISELTADFAACLSPL
SNDLQLAAAHRAAEQLRGYFIEMLADPNPFLADIRQRFVGNEEVLLANLIGLCSQTFE
ATAGLIGNALVALHRQPELRNASVDSLLAEVQRFDPSVQNTRRFMANSCEIDGVRLEA
GDVILVLLASANRDPALNENPDRFRVDRPNRRSFTFGSGRHQCPGQTLAMTIASATLT
EILARNIDPGRFTWHYRPSLNGRVPMFSEVQP

>CYP230A1   Pseudomonas fluorescens NCIMB GenEMBL AF318063 58574..59938
MTSWEREVSRGAGNRQLPVVKGWPLLGSALALIRNPLGFLQTTR
STYGDVYRVKAAHMNFVVLAGMEANRFVADKGKDCFVSSGFWEATLQEMQCPHSFIGV
DGDAHRFQRNLMKPLFSKSAFNERIPMLAQIFTDTLQARYGVDQKVSALFRHVLSQQI
GGSLQGYQPTPDEVEALMRYQNTAMNVCALKKWPRLALRLPGYRAAKKQVQALADRII
ESERTQEQTQGYFQTLKEKGQMVQPQWFTPGDMRNHAIISYLAGIDTVGATLSFMLLE
LFKQPHLHQALRDEVDACFSQGLPDADGLENMETLKNFIREVMRLYPTAYAVRRTRRK
DFEFQGYSIDKGQDIILFTTANHTDPAWFKNPQVFDITRYEEPRLEHRASGAWAPFGR
GPHTCIGAGLANILLSLNLALFLYHTDLRPACKLSDIKMDFSNPAAGLSERFAISFTPRNRP

>CYP231A1   Ferroplasma acidarmanus Archaea GenEMBL NZ_AABC02000007 
MEHDVFQYYRKMRKESPVHFNNDTGSWDVFDYKSVYFVLMNPDI
YSSDPSYAGNIPENRQGPGASFITMDNPDHKELRNVTTPYFLTSKITGYRDMIESTSK
RLMEGINKNSDFIRDYAVMLPVTVISELLGVPENDRSKFKEWSDYIIGNRSDAGFQDL
NRYMYSTMAEIFKTNTEDNIISTINKGLFHSEPLSINQKIGYVMLLVIGGNETTTNLI
GNMVKVLSEHPEIADKLRQEPELKKGFIEETLRYYSPIQFLPHRFAARDSVLNGQEIK
KGQRLSIWLGSANRDGAKFEDPDTFNMERQNNDHLAFGMGIHMCLGSPLARLEAEIAL
NDILNKFKHVKINAEKTSMLKNPMVYGFSTMQLDD

>CYP231A2   Picrophilus torridus, Archaea; Euryarchaeota
MRLNDPVHYDGAWHVYKYSDVKHVLMNDKIFSSNPGNRYSNAGG
ISFITMDNPEHKEFRDISAPYFLPSKINDYKDFIEETSNDLIKNIDNKDIISEYAVRL
PVNIISKILGIPDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHGII
NVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIIDDALKNR
SGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDL
FKIGRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMV
LGYDKLFLS

>CYP232A1   Ferroplasma acidarmanus Archaea, GenEMBL NZ_AABC02000015 12150..13295
MEIPTYKEEPFEWYREMRKNSPVYREGNMIHIFKYNTISKILSD
HQNFSSQFRDLLGEEMAAMLNEKTTPSILLLDPPLHTTLRGLVGSAFTPRSIELFEPR
IREIARMLAHAIVEKENSDIVSDLSYQLPIRVISEMLGVPESDSEIFRDWSDKLATSL
GRGPDIETQYDMADYFYKKIDRNSKGNNLISRLSTVEMDGRKLSDKEIAGFAILLLVA
GNETTTNLITNAILSLYDHPEIYNEMRKTPSLIPGVVEETLRYRSPVQSTRRYSKIDT
EIEGEEILKNDILALYLGSANRDEEAFEDGESFNPYRKEKRHMAFGQGIHFCLGAPLA
RLEARIALEEFSKAVPGFEIEKPSPDDRIDSDIMYGFRKLNLKVNRS

>CYP232A2   Picrophilus torridus, Archaea; Euryarchaeota AE017261.1:98333..99481
MYIPSYKEEPFEWYKSMRTQRIVREGNSVHVFKYNDVVTVLSNH
NVFSSQFRDLLGDDIKNELDSRAAPSILILDPPRHTELRGLVSSAFTPRKIESYDNYI
RELAAKMIENIIEKRRCDLVSEISYPLPIMVISNMLGVPEKDLKKFKEWSDALATSLG
RGPDLRTQREMSEYFLNMIDRDSNDDNLISRLSNVSIDDKKLTDQEITGFSILLLVAG
NETTTNLITNALIELSNHPDIYKELVDNNKIAGDIVEETLRFRSPVQSTRRYAKYDYQ
INGFNIYKNDFIFLYLSSANRDEEIFKDPDNFNPFRENKRHIAFGNGIHFCLGAPLAR
LESRIVLEEFAKRIESFSIERLNPDDRIDSDIMYGYKRAIINVKKINQ

>CYP233A1   Gloeobacter violaceus GenEMBL NC_005125 complete genome
MSALPPPRFNPFDSEFRQDPYRVYAHLRVAAPIHRSLGMWVLTR
YADVLAVLKDPHFSSSQIPLAVRQRSERPDQAQSHPLARLAAKSIVFTDEPDHTRLRH
LVVRAIKRRTPEQEQAHLTRIASALLERVGPKGRMDAVADYAERLPLQFMAESMALPP
DSWQTVRDWTHQLRYLLEPGLMGRGDFERVQAVLDEVIAFFEDMLAVRRQQPGDDLIS
ALDAAHREAQADRLSDEEIVYCCIMMFVAGHETTRSLIASGLLALLQHPEQLAYLRMH
PERMGAAVTEMLRYESPLQQTKRRATAAVAVGGRTIQPQEQVLLCLGAANRDPARFEQ
PDRFDITRTDNGHLAFGQGMHHCLGAALAQMEAQVALRVLLERFANLTLQDTPEWLEH
SFILRGLKTLPVQWDR

>CYP234A1   Photorhabdus luminescens NC_005126 complement(4894114..4895217)
MMNVLINEYKKKMDSVRLGDPERKGFFYDAKQAIWHCYSYDICS
YFLNSDYVTKKKLSIPLEIFSASDQSRVARFILYLNNSLIFNDDKYNTDAVSFIRGKF
NEMNFEVIANDLLSPLKQCDLLTAKHLRGVNNLLAASLVGLKASAFFSAHALNVGMFF
DGSMSGRAHFVSIAESFIAIYQQVLRQITINGGAEDVIHIEKFVADLSVTFIAAHETT
MQLIIATFLYIKSHVITVTENNIKSIVTETYRLSSPVLAVNRVFKERLIYKNSCFNKG
DRVLFYTGLANFDATVFDHPYQFQLDREGCPLSFGVGVKKCIGMNIAIHFTCQLITKI
LSCYQLDDVEIHEVTVGSLAIGCSKFTLKISKK

>CYP235A1   Streptomyces antibioticus GenEMBL AJ002638 184..1389
MEDSELGRRLQMLRGMQWVFGANGDPYARLLCGMEDDPSPFYDA
IRTLGELHRSRTGAWVTADPGLGGRILADRKARCPEGSWPVRAKTDGLEQYVLPGHQA
FLRLEREEAERLREVAAPVLGAAAVDAWRPLIDEVCAGLAKGLPDTFDLVEEYAGLVP
VEVLARIWGVPEEDRARFGRDCRALAPALDSLLCPQQLALSKDMASALEDLRLLFDGL
DATPRLAGPADGDGTAVAMLTVLLCTEPVTTAIGNTVLGLLPGQWPVPCTGRVAAGQV
AGQALHRAVSYRIATRFAREDLELAGCEVKSGDEVVVLAGAIGRNGPSAAAPPAPPGP
AAPPAPSVFGAAAFENALAEPLVRAVTGAALQALAEGPPRLTAAGPVVRRRRSPVVGG
LHRAPVAAA

>CYP236A1   Microscilla sp. PRE1 plasmid pSD15 GenEMBL NC_002806 40616..41776
MKKDLIPDPFEKTREAAGYGEMNDQNDPVTMILRLKDVRKCAHN
FKTFQSGARPGRIVVPSEVSIRDTRQIPFEVDPPEHTDYRALVEPWFKRPLEAEYREK
LSQQIGYIVEERLARDAVEVVEEFSLPLQSRALTLLLNIPIEEAETWIKWGTHVFRSE
DSPVDGDKAKILYDYIDQQIDRALEKPGEDLYTVLLNSEINGKKLSREEVKGVMILTF
AGGRDTVINAVTNSVAYFAVHPESLELLRKEPEITGRAVEELIRYFAPLTHMGRVVTE
DTQVCEYAVKADSRISLVWASANRDSSVFEKPNEVVLDRKINPHVSFGFSHHNCLGAT
HARQIMHILLKTLAEKVGSIEIQEHEDNIETWGEFERKVGYDRLKVQFNPLQ

>CYP237A1   Pirellula sp. NC_005027 complete genome 6102783..6104327
MRNGTSYLQNFFPGYRRLSRLPKQCLAINPFAGDCMPSRVRLLA
PRSDRPTQPFPHRWNYEDPVRILETYFWKADEEQGPGRHNRYLDVPGFAPVLVTRDPG
MIRAIATATGDREGQFDRDTLPSVGIARATGTDTLLYANGAEWKKQRKIAACPFGKTT
LFQPEQFCEFADTFRETVRGRIDVLRQHLTASGKKTVDIQLEPEVKVVMLEMLTNNFF
GADISYEELREKYVPALERVIDHIVKDTVKNRLGIPWRKFPSVSDRIVRAKADDATFE
ELTQRILVPRGEKKALWKQFKSDAPDAKLISNLKVFLAGALEATTSYATWAISHLARH
PDAQEKVFEEVKDIDVYTPEILAGAKYLRAVLDETLRLTPSLYFLPRRATADTWVTSA
DGRKMFIPWGTHLLLDVWHANRHEDHWGVQVSGYPANEFEPDRWRILAEWGRATKDTL
HFGFGHGPRVCPGKHLGELEVGLTVGALVKTFRFQSESPENLARAGVSTKPADGTRVC
MSLRLS

>CYP238A1   Pseudomonas putida KT2440 NC_002947 2211866..2213101  
MEILDRPQAPSDFNPMSEQSFRDPASICQRAREETPVFFYAPLG
VWMVTRREDAERVLSEWETFSSLANSPNVPEEFRSRFAPSVMADSIVAIDPPRHTQAR
NVIQRGFMKPKIDPLEPIIEQRAHEIIDRFAGESGTEIMNNYCLELTTRTLMALYDLP
LEDRPMFERIRDVSIKVLASVYEPMQEPEKSRVWNEYVSGYEYFYQLVEQRRNSDARD
IISTMASQKDNQGNPALSTERIALHLVEIAFAGTDTTAQMMANAILFLDSHPEALAAA
KADKTLWSRVFEETVRRRPSAPFAGRITTTEVEIQGVKIPAGSPVWVSLAAANTDPRH
VGCPMNFDINREAPQDHLAFTKGRHTCPGAPLARLQGATGLRVLFERLPELKVVPDQP
LNFAPMALLPVRLSLQVIW

>CYP239A1   Pseudomonas aeruginosa strain SG17M GenEMBL AF440524 34312..35472
MKDVNEVARNFDFHGEALDDIFDTYSTLRHGCPVGRSENYGGFW
FLTKSDDIFAAEQDPEAFSVYPSMMVPSVSEGIQLPPIDIDPPEHTAYRRILLPLFTP
QELKKLEQPIRDTARKLAEEFAKEGSGADASYHYSRPLPTIIFSRLAGYPEQDWPKFD
KWVDDIIYERVEKPEVANQASKDVFSYFENLLDNWKDDSESANLIDYLCRAKINGRPL
TRDELLRYCYLLFLAGLDTTAWSIRAGLWYLANNPADQQKLRDNPDLIPLACEEFLRT
LSPVQVMARTCLKDTVIRDQEIKAGERVMLVFGAGNRDEEVFPNPDKIDIERQENRHL
AFGGGIHRCLGSNLGRRELVVGIEEFLRAVPQFKPADPSEKWHGVGPLKLAF

>CYP239A2   Pseudomonas sp. KIE171 GenEMBL AJ311159 4194..5354
MKDVNEVARNFDFHGEALDEIFDTYSTLRNGCPVGRSENYGGFW
FLTKSDDIFAAEQDPEAFSVYPSMMVPSVSEGIQLPPIDIDPPEHTAYRRILLPLFTP
QELKKLEQPIRDTARKLAEDFAKEGTGADASYHYSRPLPTIIFSRLAGYPEKDWPKFD
KWVDDIIYERVEKPEVANQASKDVFSYFENLLDNWKDNGESANLMDYLCRAKIDGRPL
TRDELLRYCYLLFLAGLDTTAWSIRAGLWYLANNPEDQQKLRDNPELIPLACEEFLRT
LSPVQVMARTCLKDTVIRGQDIKAGERVMLVFGAGNRDEEIFPNPDKIDIERQENRHL
AFGGGIHRCLGSNLGRRELVVGIEEFLRAVPQFKPADPSEKWHGVGPLKLAF

>CYP240A1v1   Bordetella bronchiseptica NC_002927 3943708..3944865 
MIADTARQHRGDIMQPADPLEAVAHPDPYPYYAALARERPFYHD
DRLGLWVAAGPQAIRAVLTCPAARVRPPGEPVPAALGAGPAAQMFGRFIRMNDGAVHE
RLKPMLTAYLTQRTAADLAEPAWPAIGNDPAQVDRYLYQAPVHAQACLMGLPDEVAAS
CAREIEAFMAACRPGADAAAVARADQAAQALQARMLAHLRAARGDAALGVLRRLALAG
GVEADALAANLAGLLLQSCEAGAGLLGNALVHAGRLSPAAAAAAPDLLHTCVEIVTHV
ARHDPPLHNTRRFLAAPATLLGQSVPAGAGILVVLAAAHALAEGAWPWTFGAERHACP
GRTPALLHAAQALAHALRHGVDAPALARRVRYRPLPNARVPRFHFPPGDTP

>CYP240A1v2   Bordetella pertussis NC_002929 2545572..2546720
MIADTARQHRGDSMQPADPLEAVAHPDPYPYYAALARERPFYHD
DRLGLWVAAGPQAIRAVLTCPAARVRPPGEPVPAALGAGPAAQMFGRFIRMNDGAVHE
RLKPMLTAYLTQRTAADLAEPAWPAIGNDPAQVDRYLYQAPVHAQACLMGLPDEVAAS
CAREIEAFMAACRPGADAAAVARADQAAQALQARMLAHLRAARGDAALGVLRRLALAG
GVEADALAANLAGLLLQSCEAGAGLLDNALVHAGRLSPAAAPDLLHTCVEIVTHVARH
DPPLHNTRRFLAAPATLLGQSAPAGAGILVVLAAAHALAEGAWPWTFGAERHACPGRT
PALLHAAQALAHALRHGVDAPALARCVRYRPLPNARVPRFHFPPGDTP

>CYP241A1   Enterococcus faecium NZ_AAAK01000185 complement(2963..4222) 
MKEVPVVDIKITDLKKLYQKGYNMLEELRHEADAPVVKAKIFNK
EAITIYGSSAAKVFYDPRNFKRKGAMPKLVLKTLFGQGGVQTLDGAAHHHRKNIFMDL
MTPERMEDYHRILDKNLTQALEAQHGQFELFDLSKMVFFTSICEWAGINLSAISKDEV
EKLAEYQISMISGTFTSPIDHIKGVENRKKSEKWAQGLIEEARQNPVAGKENVALYAF
ANATDLDGQLLPLEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFSTL
QDPFIQEMRRYYPFFPMLPAISLKEVEVDGYRIPEGSWVILDLYGTDHDERTVEAPDS
FMIKRYVGKAKDISYKEEYEMIAQGGGNFRQMHRCAGEWITLHSLRVFSDQLVNKFEF
SVPEQDWTIPFNQFPTYPNSRALLYKN

>CYP242A1   Kitasatospora griseola GenEMBL AB048795 2479..3729
MADLETKFPRYELISSGKYVDRIPELHELREKSPIAWVPVMDAA
FLTRHADIVRVLKDHRMAPANLTQGIRLLSPEQQEELEPLSSAVKKWMGHTVPADHQR
FIGLLKRYFTPAMIDRMRPRVRQLSHELLDAVEPAGRMDIVSDIAYPLPACVIAEMLG
VPMDNRAQLLAWSADIGAIAEIVSYDRLMECQRSLLAMQDFVLEVVKERRAEPKDDLI
SMFVAAEREGLVSEAEILSNCVMLLFSGHETTGGLITSGLVQLFDHPDQLELLKSDPD
LMPGAVEEMLRLAGPASVISRVSTEPVEVAGSSIRSGAAVPPGADGGKRDPRVFEDPD
RLDATRRPNDHLAFATGMFYCLGAALARMEADEFFRILLDRFPDVNPGYETPDWQPVL
LISRRLKTLPVNLRGVGGSGAGDE

>CYP243A1   Mycobacterium avium AF232829 complement(389..1609)
MTPTRSTSTNWPSTPNCGNDVRSRGTRTTAGSGSSAATTPSAKP
PQRRHFRPQSTSRTPQTAWTTRARWASRDPEGQPALGLGEVDGPYHQALRHALAPFFS
PGAVEKLNPFMEQSAHWFLDQQITTGQMDLVLDYASPVPAILTMKLMGLPYDNWRLYA
NLFHSVMAVSQDSDEYAAAIAKVPAMMHEVLDYAATRRAKPEEDLTSFLIRFEFDGHR
LTDEQLLNILWNLIGGGVDTTTSQTALTVLHLGTHPDLRQQLIDHPELYRTATDEFLR
YFSVNQTLSRTVTHDVVLAGQRLRKNDRVVISWLSANHDENEFDRPDEIILDRAPNRH
VAFGLGPHRCIGSHLARLMSEVMVRAVLXRIPDYQVDVENVHQYLGNPSMTGLGQLPV
TFAPGKSRKTLRPW

>CYP244A1  Streptomyces sp. TP-A0274 GenEMBL AB088119 complement(5410..6594)
MTDMPVDPGPFDCMPELLAAARVAPVVRIPYLEEHAWVVCDPEL
VRTALTHPKMAKDITLVPQFMRKPGLMVGSQPPPEYARAMIMSDGEDHARIRRVHQPV
LSPRNTQRWGERVGVKVGGFLDELEQSRASDSAEVDVVTDYTHRVPLAFISEMLGLPL
EAERRLRSITDVMLYSSDYPARQEAVGALFGAVESWVQNPAPLRDGVITGFLAAADGP
DKVTEGEVIVWTVGMIITGYETTGSLISASLYEALRRPPEERPGTDEEIKSWIEEALR
VHPPFPHPTWRFPTEDIELGGYLIPKGAPVQVSIAAANRQPGEGADSFEAARGGHGHL
SFGLGMHYCIGASLVRLEAQIAVREFLRRFPKARLSDGSAVQWESEWMIRRLSALPAVLN

>CYP245A1 Streptomyces sp. TP-A0274 AB088119 13260..14513
MASATLPRFDLMGWDKKDIADPYPVYRRYREAAPVHRTASGPGK
PDTYYVFTYDDVVRVLSNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLD
PPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILV
ISALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRG
GDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDV
LDELRTTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANR
DPARFPDPDVLDVHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALLDGIPALGRGA
HEVEYADDMVFHGPTRLLLDLPDAA

>CYP245A2 Lechevalieria aerocolonigenes GenEMBL AF534707 complement(10860..12053)
MKPFDLKAFTGADLADPYPVYREYLTGDPVHHNGEAWYVFGYDG
VAHVLTSRDYGRRGPGGRATPIPPSHDTLSRIVENWLVFLDPPRHTALRSLLAKEFSP
AVVTGLRERVRKIAGELLAGLGDAGEIDLVEDFAAPLPILVISELLGVPARLRSWFRR
CAVDLQEASTARATRNPGALARADGAASELVEFFGGELGTRKPDDEDLVALLVNAQRR
GEALTDEEIVSTCVHLLTAGHETTTNLISKSVLALLANPAAAAEPLAGLDVTPQVVEE
LNRFDTPVQMVTRWAHQDTALGGKPIRRGDKVVLVLGSANRDPAAFAEPDRLDLRRDS
RRHCGFGLGIHYCLGAALARTEAEIGLSVLFTNFPGLRLGGEPVRYADDLVFHGPARL
PMLTR

>CYP246A1 Streptomyces acidiscabies GenEMBL AF393159 537..1724
MESPATQVDPANSPLEPYHIYPEAKSCPVAKVGLWNGTPAHVFS
GYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRGTIAREF
LPKHIELLRPAIREIVQGVLDGLAETAPPQDMLEAFAVPVASATVFRLLGIPAEDRAL
LTRCVKGVVSAVGSEDEGAEVFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQL
TFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEHPERIPLLVEELLRY
HTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDRPSVPH
VGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMTW

>CYP247A1   Actinomadura verrucosospora GenEMBL AF411574 runs off end
MRARAPLHHQVLPDGREFWSVTRYDDVCRVLGEHQRFTSERGTV
VTHLGVDDVAAGTLLTSTDPPRHTLVRRAIGARLTARAVAPWRERIPERDWDELVQLT
AMVTAPSDPHFRHGSEAATLAIAHHELVTYVKEWAARRRSAGGDDGSLLDHLMTVRVA
GAPLTDEEIALDGYSILLGANVTTPHTVSGTVLALIERPEQFGKVQADPSLVPNLVEE
GLRWTSAACNFMRYAVDDVRIAGGTIPARGAVVAWIGSANRDESQFADPHTFDVTRNA
SRQVAFGYGPHYCVGAPLARLTLRVFFKELLRRFGSLSSGGS

>CYP248A1   Micromonospora echinospora AF497482 72606..73799
MTAFDPTDADVRRDPYPSYHWLLRHDPVHRGAHRVWYVSRFADV
RAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSA
LRRLEPVIAGTVDDLLRPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWS
RDVGRTLDRGASAEDMRRGHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLM
SRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRPDLLAQAVEECLRY
DPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIERDPVPSM
SFGAGMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQPRTMFRGLASLPIA
FTPGG

>CYP249A1   Rhodococcus ruber GenEMBL AF333761 12042..13244
MTLSLATAQERYATDADVFAHDTLVDPYDTYRSLRDIGRVSYMT
RYDTWALTRYDEVRHALGDWQTFSSAQGIGMSTALNEAWKDFAPCKDGADHLPMRKLM
MQDLGPKAAAAYKEKIQQAAVTLVEELLDRREFDAVLDFAQMMPMRVFMEVLGVEPDI
EQRRTMLHWGTDTYNCAAPDGLYDDTLPSMDKLYSWALENITPETAREGSVAASTWES
VERGDITDVQAVATLAAYVTAGLDTTAGTLGNTIAQFAANPDQWAIVRDDPKTIPGAI
LEGIRFDSVAQWFTRVTTRDVEYDDIVIPAGSRTYHSYAAANRDERHYRDPDSFDVLR
NPTDHVGFGYGPHMCVGKSVSNTEMIALWTELGRRVDRIEQIGPKKQHINNLIRSLDS
LPVRIYPK

>CYP250A1   Arthrobacter aurescens GenEMBL AF146701 
MKEPLDFADPTLYQNPVPAFNKMREEHPVFWSDSAGSWVVSRHA
DVVRVLNNLEDAQASLFKINDYAEQCPFGKGTAISRGIENALVTTDLPDHPRLRRHTA
PLLTRRSVERDYAETVEQTVIALLEGIEEDTRFDVLDSISVPLPLAVVTKLIGFDAED

>CYP251A1 Streptomyces peucetis AJ605552
MQPAASRSVPVAPGAVPLLGHALKLWRDPLGFLKSLRENGDLVR
VNLGTMPMYVATSAELIHEVTVRQARSFEKGRFFDRLRPLAGDGLATANGEVHRKHRR
LIQPMFHPGRITMYAETMSSNALALADSWTAGQEVEMEQAMAQFAIETLATTLFSTDI
GQPAVVAIRENLPVVLQNLLIRAASPKFLDRFPIRPNRDFDAAAAKLRSVIDEVVATT
RRAGTSEHNDLLSVLLGARDSETGEYLSDTEVRDELSTILFAGAETTASTLSWTFYQL
AEHPEVEAELVAEIKDVVGDRPVSIEDVPKLEAVRRVLDEVIRLHGVTMLMRRTTAPV
ELGGHLLPVGTEVGFSLYAMHRDPTLYDDPDRFDPDRWLPERRGDITRQAYIPFGAGN
RKCIGDAFVWTEATIALATVLARWQLRPLPGHTPKEVASAVAHPDRMPMTVLPRDA

>CYP252A1 Streptomyces peucetis AJ605545
MSPSTRSETADPQPPGERGTMSPTLSGHLRRPPGPAGYPVVGCG
PDLVRDLVGTFTRAWREYGDIVSFRLPGKRNLFLIVHPDHIKHVLDDRQPNYPKDPLS
VGKFEPWVGQGLFTSNGDFHFRQRRLAQPAFKGSRISGFGPAMVEATSDLVRDWHGRA
TREETFDITPEMFRLALTIVMQTLFSTDVSNRAGELARAVRICNAYTNVRLQRFVELP
QALPSKARSRFLRARATLDSFVYGLIAERRRDPAPPDDLLTRFLNAQDEQTGERMSDK
QLRDEVVTMFLGGYETTALSLVWAFSLLSRHPEAERKVRSEVAEVCGDREPAASDLPR
LRYLRAFYQEVLRLYPSVWTLSRSPLEDDEIGGYHIPAGSQVFISPYLMHRHPGFWEN
PEGFRPERFEKSATGGAPLYAYIPFSRGPRLCPGSSVAVLEAPLVIARMLQDYRLTLA
GGHVCEPTSNVFLYPRAGMPMRLQHFKSTGEGAA

>CYP253A1 Streptomyces peucetis AJ605548
MCPPSSPTTYPSSPCDPPPLRKGLVRMTTTLVPPGPRGHPVLGS
IREIQRDNVSAFMEAFRHHGDIVNFRGPLRINLLAHPDYVQHVLRDQHKRYPRPRKVQ
GCLSTIVGDGLVAAEGTSWLRSRRLTQPAFHRDILRRFGDSFTASTAELLDGWERRAR
DGEPLDIKSEMMHLSLANLARALFRTEWTDEVSRIEPAVQEALGFTHRRMTSPVDPLK
FPSAARTRFRGALETINSLLYPMVAERRRDGGGDDLVSLLIDAVDPESGGMFTDEQIR
DEVSGFFVAGHETVSTALSWTWYLLSLNPESRRRLQAEVDEVLAGRVPTVDDLPKLTY
TTMVLQESMRLYPPIFVYMRCAAEDDVIGGYHIPEGRWVVVCPYVTHRHPEFWDNPEG
FEPERFTPENSANRHRMAYLPFGAGPRKCIGDSFAMLQMPLVVAMIAQRFRLDLVEGQ
QVFPEPAISLRPRDPLMMWLRPNEETP

>CYP268A1   Mycobacterium avium subsp. Paratuberculosis AE017235.1 
MTGVIAERIGIMAVLTGESGTDRSGRPYDEIDLSSRAFWSGTAA
ERERSFAVLRAERPVSWHPPVEDSLLPDPTDPGFWAVTRRADIVTVSRNNDVFLSGHG
VMFESIPAELLEASQSFLAMDPPRHTKLRKLAHAALSPRQVRRIEDSIKANAKAIVEE
LRSAGSGCDFVDHCAKELPIRTLSDMMGIPESERERMAHATDALVSWADPEFLNGRPA
LEVLLENQMYLHQVVGDLATQRRERPGDDLISSLVTAEVDGDRLEDAEVAAFFVLLSV
AGNDTTRQTISHTLRALTVFPDEKFWLLEDFGHRIGTAVEEFIRWASPVMTFRRTAAA
DVELGGQTILAGEKVVMFYPSGNWDTEAFDHPERLNLGRDPNPHVGFGGGGLHFCLGA
HVARAQLRAIFSELFRQLPGIQAGEPTYLAGNFVHAIRAMPCTF

>CYP268A3   Mycobacterium smegmatis MSMEG4612 TIGR
MTVLPITRPYDAVDLSSRAFWATTAADREVAFAQLRAERPVSWHPPVEDA 
LMHDPDDKGFWAVTRHADIVAISRDSETFLSGQGVLFENVPQELLEASQS 
FLAMDAPRHTLIRKLVHSAFTPRQVARIEDSIKANAAAIVAELKAAGSGV 
DFVDHCAKELPIRTLSDMVGIPEGEREKVAHAADALVSWADPIYLAGRHP 
LEVLLENQMYLHQVANTLAAERRENPGNDLISALVHAEVDGDRLTDAEVA 
AFFVLLAVAGNDTTRQTTSHALKALTDFEDQRAWLMEDFDDRIGVAVEEM 
VRWASPVMTFRRTAAVDVELGGRQIAAGEKVVMFYASGNWDTTVFDRPDV 
LDLGRKPNPHLGFGGGGRHFCLGAHVARTQLRAIFGELLHQLPDIRAGEP 
EYLQGNFVHAIRAMPCTFS

>CYP268B1   Mycobacterium vanbaalenii PYR-1 
MSGSPDRRRSADHDHPAAVAACRQLYKLTVKCHANSVTAPSLHEREHSAIDITSHDFWSRPFAQRDESFA RLRAGDGLSWHAPFPSLFPMEEPGYWAVTRRADIAYVSQHPELFTSERGVALDPMPAEVQRFASFFLTMD PPQHTTYRRLISSAFTPRNVRQIEEQIQRNAVAIVDDLVGAGDIDFVADCSARLPMLTIMEMLGVPGADQ PAVALAAEKLFSMSDDEYSSLEERAANTLNEIMLLSSTGAELAKFRRAHPGDDLMTGIVNAEVDGQRLTD EEIGAFLILLASAGNDTTKQTTTHAMMALVENPQQRAWLMADFDGRIGAAVEEFVRWSSPVLQFARFATR DTEINGQPVAEGDKVGLFYCSANRDEAVFDNPAGFDLSRSPNPHLGFGGGGPHFCLGNQLAKAELRNLFR 
ELLTRLKTVEFGEPDLLHSSFVHGVKRLPAHVR

>CYP268B2   Mycobacterium smegmatis
MTVASSAQAREYSPFDITSHEFWSRPFAVRDETFAQLRAAEGLSWHQPLS 
TLFDVEEPGFWALTRRADIQFVSQHPELFTSAQGVALDPMPADVQKFATF 
FLMMDPPEHTVYRRLISSAFTPRNVRRIEEQIHANAVDVVDQLIGVGNVD 
FVEACSAQLPMRTISDMLGVPKADQPALAKAAEKLFSMSDDEYSSLEERA 
VATINEIMLISNTGVELAKFRRANPGDDLMTSIVNAEVDGHRLTDEEIGA 
FLILLASAGNDTTKQTTTHAMMALAAHPDQRDWLMADFDGRIGPAVEEFV 
RWATPVIQFARFATEDVEVAGQTIRAGEKVGLFYCSANRDEAVFTDPQRF 
DLSRSPNPHLGFGGGGPHFCLGNQLAKTELRNLFRELLTRLKTIEFGEPE
LLHSSFVHGIKRVPAYIR

>CYP268C1   Mycobacterium vanbaalenii PYR-1 ZP_01209026.1, EAS21466.1 
MQIDEYLAATSDNKPDHCDIDISRKAFWARPADEKMEIFAALRAEHPVSWQRPIEGAVVPDPDDPGFWAV VRHADIRQVSHDNRTFISGQGVMFDRLPPLFLEMALSFLAMDPPRHDKLRRLVNKAFTPRQITRIEDKID LVAKEVVDGFIADPTGEIEFMDRCASRLPLRMFCEMFGVPDHLEERTVEHVIGSVSWSDEEILAGRSAAD MQLESIGGLHQVAQEIIEMRRQQPGDDIISSLVHAEIDGQMLTDFEISSFFCLLSGAATDTTKTTLGHAV RALSLFPEQHAWLLEDFDNRIGTAVEEFIRWATPLLTFTRTAAVETELGGRRIMPGDRVVMIYQAGNFDE DVFDRPRELDLARSPNPHVSFGGGGVHYCLGANLARSMLRAELRELLLRITEFETDAPDMLATNFIHGLK RLPFRFTPQ

>CYP272A1   Mycobacterium avium subsp. Paratuberculosis AE017234.1 
MTEAGGFVDQTVTGVAEPQPMYKALRESNPVFRSTQAVVLSRLA
DIEMALKHTELFSSNMDAVDLGNVRPLIPLQIDPPDHAKYRRILDPLFTPREMARREP
LVTELVNEMIDRFAPRGECDFHAEFAVPLPCTVFLQLLGLPLEDLDRFLLWKDGVIRP
AGDSGFDRRHESSAGVAQQIYEYFDKAIDEHIAVPRDDVLSAMIAADVGGQPLSREEL
LDICFLFLIAGLDTVTDSLDCFFVYLARHPQHRRQLVERPDVLPGAVEELLRWETPVP
GVARVATQDVEVGGCPISKGERVSPLLGAANTDPAEFPDPEIVDFTRSPNRHRAFGGG
PHRCLGSHLARMELRVALREFHRRIPDYEIRPGTQLTYTAALRSVESLPLVFPVR

>CYP279A1   Mycobacterium avium subsp. Paratuberculosis AE017241.1 
MTVGAAPPSVFDSDLPTLHYHSDETPAQVYPRLREAQRRAAVAI
GPHGPEVLSYHLVRSVLRDPRFQIPPGINLLAQGIDSGPLWDKVANSLLCLEGDAHHR
LRSLCSKAFTPRTVARLHDTMAAVMNELVDRVAAAGRCDVVTDIARPYPVPIICALLG
APREDWRRFSSWADDVFKAFSFTVDLREVEPVVMRAWRELDDYVDEMVARRRHNLTDD
LLSDLIRVGDEGDRLDAAELRMLAGGLLLAGTDTTRNQVAASVQVLCEHPDQWELLRQ
RPELAMRAVEETMRHSPIACGTLRLVVEDAELDGHLFPAGTAVLVNTFAANRDPVVYN
DPDRVDITREAAPPILTFGGGVHYCLGANLARREIAEALNVLANRLRNPRLAGPAPWK
PMVSLSGPTSLPIEFDR

>CYP279A3   Mycobacterium vanbaalenii PYR-1 ZP_01203523.1, EAS24515.1 
MSGDYVRDSARDHAFPCPYPPHGHTLFSIRKSNRPGSEATMVVSPTVANVFDAGLPTLTYDVFSTPAQVW PDLHDAQRTAPIAIGPMGPEVLSYEMARAVLRDTRFTIPPGINLAAQGITSGPLFDKVMSTLLCLEGSEH QRLRKLVSKAFTPRATERLHDTIVAVVDELVDNIAGARRCDVVADIARPYPIPIICALLGAPREDWRLFS DWTEDVFRAFSFSTDVATVQDDVMRAWNELDDYVDRMVAHRRRHLTDDLLSDLIRAEDDGDRLSTSELQM LAASLLMAGTDTTRNQLAASVQALSERPDQWALLADRPELAMRAVEETMRHSPVVCGAPRIVLDDVEFDG YLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGVHYCLGANLARRELAEALRILAGRL 
SNPRRSGSAPWKPMLGMTGPTVLELEFDA

>CYP279A4   Mycobacterium vanbaalenii PYR-1 ZP_01203646.1, EAS24638.1 
MALPHSRLRTRTRLRPRDHLAVGDVHAAHAAADPDEEDAVTAAATKPSVFDAGLPTLSYDVTDTPQQIYP QFRAAQRIAPIALGPIGPEVLSYEMARTVLRDPRFVIPPGIHLSAHGITSGPLWDRVTRSILNMEGDEHR RLRSLVSRAFTPRATARMHDAIHLVVNELLDAIQDTGRCEFVAEVARPYPIPIICALLGAPREDWQLFSR WAEDIFKIVSFDCDLAEEEPVVLKAWAEFDDYIDGMIADRRRHLSDDLLSDLIRIEDGGDRLDAAELRML AFSVLVAGTDTTRSQLAASVQVLCEHPDQWALLRADSDLAMRTVEETMRHSPSMCSTVRSVTADVEVGEY TFPAGTFILVNTYAANRDHTVYDDPTRFDITREDPPPILTFGGGVHHCLGANLARLELAEALKILSHRFR 
YARRTGPVPWKPLLGLSGPTSLPLEFGP

>CYP279A5   Mycobacterium smegmatis MSMEG4219 TIGR 
MTRMTVAELTPISYHHATMPAEVHDIIRQARANGPLALGPYGPEILGYEL
VRAVLRDERFEVPRGMFLAAQGITSGPLWERANNTLVGLGGPAHLRLRRL
VARAFIPKAAERLRATCVDIVTELVARCVPAGRCDVVADLAVPYAVPVIC
ALLGAPARDWARFSAWADEIFKMFSWDLGEHAEAVETAWKELDAYVDDMV
VRRRHTLTDDLLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQLA
AAVETLCDHPREWDLLAEHPELAPTFVEELMRFSPATLGTVRIAKEEVEI
AGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLHY
CLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR

>CYP282B1   Mycobacterium vanbaalenii PYR-1 NZ_AAPF01000001.1 
261164  VTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYA  261343
261344  ECVQILQDWEHFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFS  261490
261491  PARMKALRPEIGVETDRLIDDFIETGSGDLAAVAWRQPGIVFFKYLLGMPVDDVPLCV  261664
261665  ELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMIDVLLSAEIDGEKLAFAD  261844
261845  VVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIRFAGSIHG  262024
262025  IPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHR  262204
262205  CLGSNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKR  262372

>CYP284A1   Nostoc sp. PCC 7120 GenPept BAB73318                 
1 MLQYITAQID NSSSFPYLVT VLSVTTIAGT FAWRWWKQKK KYKSLQSLPS PPKHWLLGNL
 61 PQVLAAVKQK KLFQLFFDWS QQLGPMYVVW NGSSPVVILS KPKVIEDTIV NGMRDGSLIR
121 SARLRQAWND ISGPILIGET GNEWQWRRKV WNPEFSSSSL AKYLKIINQA CVQVIDTLKE
181 TALPKEVEVD PLFVELTMRV ISSLVLGIPV DRKITTNEGP PLEVLKVYEA MCVVGYRFLR
241 QATGEKIWMK YLPTKNSQDY WASRRYLEEF LTPRVDLALQ MREQSTDFPQ VSPLFRESML
301 VRIAAKEPKY NRQTLIAESV EFLIAGTDTT AHTLSFAVGE LSLNPRVFQK AREIVDQAWQ
361 GQDNINTESF KELAYISAIL KETLRLYSIA SGSTSLEAQR DTVIEGKVIP SGTRISWSML
421 AAGRDPEVYA NPEEFLPERW LDKSKETSSL PMIDFGSGPH RCLGEHLSML EGTMMLALLL
481 RHFDWELVNG RSSLEQLQQN LLIYPSDKMP VRFRLRN

>CYP284A2   Nostoc punctiforme GenEMBL NZ_AAAY02000016.1 77% to 186A1
MFQQIAAQITFSDSFPYLVTALGITSTAGIFGWRWWKQKNTYKS
LQSFPSPKRHWLLGNIPQVLAAVKEKKFFQLLFDWSQQLGPMYVYWTGFP
18635 VLVLSKPKVIEDTIVNGMRDGSLIRSQRASKAWNDIGGPILLGQNGSEWQYRRKAWNPEF 18456
18455 SSSGLSKYVEIINQACEQIIEKIQSVASPEVQVDPLFVELTMRVISCLVLGIPVDKN 18285
18284 IATNEGQPLDVLKVYEAMSIVGYRFLRVATGEKIWMKYLPTKNSRDYWAARRYLEEFIT 18108
18107 PRVDLALQMREQNQTDLTQVSPLFQESMLVKIAAKEPKYNRETLVAEVIELLIA 17946
17945 GTDTTAHTLSFAIGELALNPRVFHQAQAVVDQVWESQGTINGESLKELNYIRAILKETLR 17766
17765 LYSDDS 17748
      XXXSLXAQR
      DTVIEGTVIPRGTKIYWSMLAAGRDPEVYSHPDEFLPERWLEKGKEN 17579
17578 SQLPMIDFGSGSHRCLGEHLSMLEGTMMLALLVYYFDWELVNGRSSLEQLQQNLLIYPPD 17399
      RMPVRFRLRK* 17366

>CYP285A1 Streptomyces tubercidicus AY549199
MKLSQSVPPEQIDLDSVDLTDSVLYGEGDPHSIWNAMRQRDPVR
WQQVDDTLGFWSVTKFEDADLVLRDHTLFTSQRGTMLFLLGKDDPARGRQMAATDPPR
HTRMRAPMQRALTNKQVEKYREAVTGEVRRLLEPALSEEPFDFAESMMTLPMTAAGTM
MGLPREDWTRLTQLTTMSIAPDDPEFAGPGSAEETLKAAHRELFAYFHDILRDRRNNL
GDDLISLLLGMEIDGRSLETGAILSNCYSLILGANVTTPFVPTGAMAEIVGTPLLHEW
RTDPKLMNTGVDEALRWSSPTNHFMRYALQDIELRGKKIRAGDAVVVWLGSANRDEEV
FANPFTFDIRRKPNRHMAFGSGPHYCVGHTVARMSMKILFTELFESFEDFELVGEVEH
LHSNFVAGIKHMPMVAKVRAGAARSHTGLVK

>CYP286A1   Deinococcus radiodurans GenPept AAF11281   
1 MVPAPPFLGH AAEMGTIKLR PFLTRCYQAY GPVFQLTVPG QKITVLAGPE ANLFAMKEGH
 61 RVLRSLEAWR DNDHEMGSDR SMISLDGAEH RAYRRVEGRA FARSFFAAGL RPALAVLAED
121 LAPFQPGDVL PVATWCKKTI TEQLARMAVG GTVRPYLPDL LHFIQTALQV TVNRQLPPAV
181 LRLPKYRRAK ARIFQMVDDL IEDHRQNPPE KSGRAPDLID DVLADQQVNP ERWEHPDVRL
241 AALGAFIAGM DTAANSLAFV LYRMHLHSEF LPALRAEADA LFRDGPPTAE ALGRSPLLHR
301 FVMETLRVHP IAPALSRTLT EDVEFAGHRI PAGTPVIIGT TVPHGLPELF PDPEHFDPGR
361 FAPGRAEHRQ PGAYAPFGVG SHTCAGSGMA EGLIMLGAAA ALRTLDLSLE PDYVLRQTAK
421 PTPSLDNKLQ LRVNAVRHNP VFLVH

>CYP287A1   Deinococcus radiodurans GenPept AAF12016      
1 MLSSLHDLPE PASRPGSGHL QDWAARPLAL IEEGATQALA AGQDLFRLRL GLPAVVGLSP
 61 AWNRRVLTDL NTFVSAGSFS AVVPYLAGGV ILTDAPGHGA RRRALNPGFG KGSVQQLRER
121 MRQASSPVPT GRFNALAWAD ETVRRQLNAA YFASEFDDRL LAAFLAPLRR PFPVPALPRP
181 LLFRRVEQEI RRLAERRLRE GGDDLLSTLA PLPGGLLETR ISLAAAHDTT THALAYAVWE
241 LAKAPQDQTP HTHSAVLKEV LRLYPPGWMG SRRLSRAAEW QGTEIPRGTL ALYSPYLTGR
301 DPTLWERPLD FRPERWEKSP PAWAYLPFGG GERTCLGVHL AQTLILDVLA ELPPLQAHWG
361 NDEPHPGITL GPRGPLVVER R

>CYP288A1   Corynebacterium efficiens YS-314 GenPept BAC17372                 
1 MIHNMETRCG SYHRATGILT GDDMTSDSTT ALSTAPETTS GGCPYGHGNP DATGTPGTSH
 61 HGYEPFNMTN PFPAYEELRR EEPVMFDERI GYWVVTRYDD IKATFDDWET FSSENAQAPV
121 RKRGPQATKI MEEGGFTAYS GLSARIPPEH TRIRAIAQKA FTPRRYKALE PDIRANVVAR
181 LETMLKQGAP ADIVPALAYD IPTITILTLI GADVSMVDTY KRWSDSRAAM TWGDLSDEEQ
241 IPHAHNLVEY WQECQRMVAD AHANGGDNLT ADLVRAQESG QEITDHEIAS LLYSLLFAGH
301 ETTTTLISNC FRVLLAHRDQ WEALIEDPKK IPAAIDEVLR YSGSIVGWRR KALRDTEIGG
361 QPIKKGDGVL LLMGSANRDE ARFDDGETFD ITRPNAREHL SFGFGIHYCL GNMLAKLQAK
421 ICLEEATRLV PSLELADDQS VEFRENLSFR VPVSVPVTWS N

>CYP288A2   Corynebacterium glutamicum ATCC 13032 GenPept NP_599791  
1 MTSQTSQQST STGGCPFGHT SESTSHHGYQ PFDMHNPFPA YKELRQEEPV MFDERIGYWV
 61 VTKYDDIKTT FDDWETFSSE NAQAPVRKRG PQATQIMTDG GFTAYSGLSA RIPPEHTRIR
121 AIAQKAFTPR RYKALEPDIR AMVIDRVEKM LANDQHVGDM VSDLAYDIPT ITILTLIGAD
181 ISMVDTYKRW SDSRAAMTWG DLSDEEQIPH AHNLVEYWQE CQRMVADAHA HGGDNLTADL
241 VRAQQEGQEI TDHEIASLLY SLLFAGHETT TTLISNCFRV LLDHPEQWQA ILENPKLIPA
301 AVDEVLRYSG SIVGWRRKAL KDTEIGGVAI KEGDGVLLLM GSANRDEARF ENGEEFDISR
361 ANAREHLSFG FGIHYCLGNM LAKLQAKICL EEVTRLVPSL HLVADKAIGF RENLSFRVPT
421 SVPVTWNA

>CYP289A1   Brucella melitensis 16M GenPept AAL54121    
1 MRAGGIMTSP TERPKQDWDP RSEAVLSDQI GAYDAMRHQC PVAHSDYLGW SLFSYDDVVR
 61 VLDDHETFSS VVSAHLSVPS GMDPPQHTAF RQLVERYFEP ERIKAFEPIC REISKKLVCE
121 LPRDAEIDLV TQFAQLYAVR IQCAFLGWPD SLQGPLLDWV HKNHAATLAR DTKAMAAIAL
181 EFDEYIRDLL DERRKLGADA PDDVTTRLLR DRIDRRNLTH EEIVSILRNW TVGELGTITA
241 CVGILCHYLA KSQQTQALMR GGPDLLPAAI DEILRLHAPL ISNRRVTTRA VVVGGREIPA
301 GEKITLMWAS ANRDEAVFDK PDELRLNRDP ALNLLYGRGI HVCPGAELAR AGLRILMEEL
361 LGQTRKLDLV PGSVPALAVY PASGFSRLPA RIS

>CYP290A1   Caulobacter crescentus CB15 GenPept AAK22930  
1 MDLISQTVVD GKAGPGAPPT YPTLKDVDLA DIFRFTKGQP WADFARMRQE APVMWHPEPM
 61 GGPGFWALTR YEDVHRVNGD PETFSSQRGG ILMSMGAPEK RHALLFRASM DTMINMDAPH
121 HLQLRREHMP YFTPSYLRGL TERVKGEVTR LLDEMEPLLA NGAEIDMVEH FSSVLPLFTL
181 CEILGVPPED RPKFLTWMHY LERAQDLAVK QANAPMQPTL ELMQFVMDFN NNVEEMFEYG
241 RTMLHKRRED PKEDLMTAIA RAQLDGAVLP DEYLDGSWLL IVFAGNDTTR NTLSGAMRLL
301 TEFPDQKQKL IADPSLLGGA VDEFIRMVSP VVYMRRTATR DVEVNGQLIR EGEKAIMYYG
361 AANRDPAMFE NPDQLDVTRA NAGKHIAFGY GPHTCIGKRV AQIQLEEAYR QILARFPDLN
421 WTGNIEIAPN NFVHAISKLG VKRG

>CYP291A1   Mycobacterium vanbaalenii PYR-1 ZP_01204524.1, EAS25516.1 
MSRLSNPLHSPAFYAGDPFPVYRELRATDPVCWNDEHEFWALLKYEDIRYVSTNPALFSSARGVTVPDPA LENPVMEGSLIFTDPPRHRQLRKLINSGFTRRQVAILEPKLRAFARAALDAIDPSATEFAEQVAAPLPTR MIAELLGAPDEDWEQFRTWSDATVGMDDPDVELDTFAAMGELYQYFEAQIARRRDGTLRDSDDLLSVLVA AEVDGVRLTDQDLLQFCLLLLVAGNETTRNLVALGTLALIENPDQFRLLRQRRDLVPTAVEEMLRYASPV ANMTRCATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNPNPHLAFGCGEHSCLGAQLA RLEARVLFEELLNRFDHIELDGDVLRMQATMVPGVRQMPVRLSATAAEPRETGTAAVSV

>CYP291A2   Mycobacterium flavescens PYR-GCK ZP_01195006.1, EAS08752.1 
MGRRTDLESP CGALHPSARI HPARTSPARQ RHRRRLGRRR ALGVPARPAR HPDRPAAHVT
PAVISAIPPV ASLAQKEIAL PPPLHSPAFY AGDPFPAYRE LRATDPVTWN EEHGFWALLK
YEDIRYVSTN PALFSSARGI TVPDPAIENP VMEGSLIFTD PPRHRRLRKL INSGFTRRQV
AILEPKLRAF ARTALDAIDP AGGTEFAERI AAPLPTRMIA ELLGAPDEDW EQFRRWSDAA
VGMDDPDVEL DTFTAMGELY QYFEKLIALR RNGALRDSDD LLSVLVAAEV DGVRLSDQDL
LQFCLLLLVA GNETTRNLIA LGTLALIEHP QQFRLLREHP ELIPTAVEEF LRYTSPVANM
TRCATRDVEM RGRLIREGQY VTMLYGSANR DEDIFGPTSE QLDVTRNPNP HLAFGCGEHS
CLGAQLARLE ARVLFEELLA RFEHIEPAGE VLRMQATMVP GVRAMPVRLR AATDPRRAKARAG

>CYP291A3   Mycobacterium avium subsp. Paratuberculosis NP_961518.1, AAS04901.1 
MQTHPPLRSP SFPLHSPDFY AGNPYPAYRE LRATAPVCWN DVTNFWALLK YEDIRFVSSN
PALFTSTRGI TIPDPQLPNP VQQGSLIFTD PPRHRQLRKL INSGFTRRRV SVLEPKIRKI
VRGILDGIER GAVHEFAEQI AAPLPTRMIA ELIGAPPDDW EQFRAWSDAA TGTADPEIEL
DPAVAAGQLY EYFQRLIAAR RARPRADLLS VLAEAEIDEH RLTDEDLLNF AFLLLVAGNE
TTRNLIALGT LALIAHPDQY RLLVEEPARI PLAVEEMLRW NSPVVHMART ATADVEIRGQ
RIRAGEVVVM LYGSANRDED VFGPDSEEFD VTRHPNPHIA FGCGEHSCVG AQLARLEATV
FFEELLRRYP RIELVGEVDR MRATMVPGVK RMPVRMGA

>CYP292A1   Mycobacterium vanbaalenii PYR-1  ZP_01203641.1, EAS24633.1 
MTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYAECVQILQDWE HFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFSPARMKALRPEIGVETDRLIDDFIETGSGDLA AVAWRQPGIVFFKYLLGMPVDDVPLCVELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMI DVLLSAEIDGEKLAFADVVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIR FAGSIHGIPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHRCLG SNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKRVTA

>CYP292A2   Mycobacterium flavescens PYR-GCK ZP_01190587.1, EAS12881.1 
MSPTVEQHAE NWDLRHADFN DPDFLYDVYT VMRGNSPFAR TDNPFLSATP SGAWVAVRYA
ECVQILQDWE HFSSSPTPEG AEQLAGDLVI TLDPPRQQKF RKVLNPYFSP ARMKALRHEI
AAETDDLIDV FIESGSGDLA EVAWRQPGIV FFKYLLGMPV DDVPLCVELT DTALNGATEE
ARMGAWGGLY QHLHDAVTAR TAEPPRDDMI DVLLSAEIDG EKLAFGDVVS NAMLLVQAGL
ETTASAMSFA YHYLATHPAE RDRLIAEPDL LARAVEEFIR FAGSIHGIPR TVAKEVELSG
CTFSPGESVI VNYASANRDE EQFPEADRCI LDRRENRHLG FGAGVHRCLG SNLARLEFQV
GLERVLTRMP DFTLTAGAEA KFHGNSVTRG FRSVPVTFTP AARTR

>L76374 Mycobacterium avium paratuberculosis 39% identical to 107B1
483 LIFTDPPRHRQLRKLINSGFXXRRVSVLEPKIRKIVXXILDGIEXGAVHEFTEQITAPLP 304
303 TRMIAELIGAPPDDWEQFRAWSDAATGTADPEIELDPAVAAGQLYEYFQRLIAARRARPR 124
123 ADLLSVLAEAEIDEHRLTDEDLLNFAFLLLVAGNETTRNLI 1

>AF071147 Streptoalloteichus hindustanus cytochrome 61% to 105C1 
LLIAGHETTANMLALGAFALLEHPEQLAELRANPDLMPGAVEEL
MRYLSIVHIGPVRTAVADVEIEGQLIRAGESVTVSVPAANWDPAKFPEPERLDLTRRT
SGHLAFGHGVHQCLRQNL