P450s that have appeared since the 1993 P450 nomenclature update.
This is Part B of the P450 bibiographic files.
Sequences covered are CYP3 to CYP9.
This list now includes all Drosophila P450s
This includes references that were incomplete and duplications
of sequences that were already in the update. If a sequence
is assigned an accession number that was not in the old update
it is included in this list.
Added 4A23-4A25, 6X1 9J1, 9J2,
4F19 N-term (Jan 2002 added Fugu 3As and minipig 3A29v5)
Added 6P2, 6P3, 6Y1, 6Z1, 9K1 added 6Z2, 6AA1, 6P4 and 9L1
Added 4C31, 4C32, 4C33, 4C34, 4AN1, 4AN2, 4AN3, 4AP1, 4AP2
Added all human genes and pseudogenes
Added CYP8B1 pig
Added 6AB3, 6AE1, 9A6 and 9A7, 4G19
Added 25 Aedes and 104 Anopheles sequences
Added CYP9G2
This list was last revised on April 7, 2003.
Added Cyp3a58-ps to CYP3A62, wallaby 4B1, 4B3
July 2, 2003 added 4F42, 3A64, 4T6, 4T7
Last revised Aug 19 2003, added 9A12
Last revised Sept 26, 2003 added accessions for some old seqs.
Last revised July 8, 2004 added Anopheles funestus CYP9s
Last revised Jan. 31, 2005 added Anopheles funestus CYP6s and 4C25
Last revised March 17, 2005 added Anopheles funestus CYP9L4 and 9K1
Last revised June 24, 2005
Last revised Jan. 4, 2006
Last revised Dec. 31, 2007
Last revised June 22, 2010
3A Subfamily
3B Subfamily
3C Subfamily
3D Subfamily
4A Subfamily
4B Subfamily
4C Subfamily
4D Subfamily
4E Subfamily
4F Subfamily
4G Subfamily
4H Subfamily
4J Subfamily
4K Subfamily
4L Subfamily
4M Subfamily
4N Subfamily
4P Subfamily
4Q Subfamily
4R Subfamily
4S Subfamily
4T Subfamily
4U Subfamily
4V Subfamily
4W Subfamily
4X Subfamily
4Y Subfamily
4Z Subfamily
4AA Subfamily more CYP4 subfamilies follow
5A Subfamily
6A Subfamily
6B Subfamily
6C Subfamily
6D Subfamily
6E Subfamily
6F Subfamily more CYP6 subfamilies follow
7A Subfamily
7B Subfamily
8A Subfamily
8B Subfamily
9A Subfamily
9B Subfamily
9C Subfamily more CYP9 subfamilies follow
3A Subfamily
CYP3A1 rat
GenEMBL D13912 (2023bp)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of steroid-
induced cytochrome P450 3A in rats
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: only 11 differences and two missing amino acids with
3A1. All changes are limited to a 113 amino
acid region, M10161 probably represents a hybrid seq. with Cyp3a2.
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S30378 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL L24207 (2015bp)
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequences of a new rat CYP3A form.
Unpublished (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL D29967 (2026bp) PIR S39797 (502 amino acids)
Kirita,S. and Matsubara,T.
cDNA cloning and characterization of a novel member of
steroid-induced cytochrome P450 3A1 in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
GenEMBL M28452 (897bp)
Wrighton,S.A., Schuetz,E.G., Watkins,P.B., Maurel,P., Barwick,J.,
Bailey,B.S., Hartle,H.T., Young,B. and Guzelian,P.
Demonstration in multiple species of inducible hepatic cytochromes
P-450 and their mRNAs related to the glucocorticoid-inducible
cytochrome P-450 of the rat
Mol. Pharmacol. 28, 312-321 (1985)
Komori,M. and Oda,Y.
PIR JX0334 (502 amino acids)
A major glucocorticoid-inducible P450 in rat liver is not 3A1.
J. Biochem. 116, 114-120 (1994)
Note 12 amino acid diferences and 1 two amino acid deletion vs 3A1
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S36137 (30 amino acids)
Ribeiro, V. and Lechner, M.C.
Cloning and characterization of a novel CYP3A1 allelic
variant: Analysis of CYP3A1 and CYP3A2
sex-hormone-dependent expression reveals that the CYP3A2
gene is regulated by testosterone.
Arch. Biochem. Biophys. 293, 147-152 (1992)
This sequence agrees exactly with PIR JX0334, a 3A1 variant
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A1 rat
PIR S27107 (24 amino acids)
PIR S21697 (504 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A2 rat
GenEMBL M74443 (4230bp) U09725 to U09734 13 exons
Miyata,M., Nagata,K., Yamazoe,Y. and Kato,R.
A gene structure of testosterone 6-beta-hydroxylase (P450IIIA)
Biochem. Biophys. Res. Commun. 177, 68-73 (1991)
U09725-U09734 report corrections to M74443
CYP3A2 rat
Gen EMBL X79319 (8014bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL X79320 (1936bp) PIR S46938 (504 amino acids)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2
unpublished (1994)
CYP3A2 rat
GenEMBL U09742 (1936bp)
Miyata,M., Nagata,K., Shimada,M., Yamazoe,Y. and Kato,R.
Structure of a gene and cDNA of a major constitutive form of
testosterone 6-beta-hydroxylase (P450/6-beta-A) encoding CYP3A2:
Comparison of the cDNA with P450PCN2.
unpublished (1994)
CYP3A2 rat
Yamazoe,Y. et al.
Transcriptional elements directing a liver-specific expression of
P450/6bA(CYP3A2) gene encoding testosterone 6b-hydroxylase.
Arch Biochem Biophys. 318, 71-79 (1995)
CYP3A2 rat
PIR S30379 (25 amino acids)
Cooper, K.O., Reik, L.M., Jayyosi, Z., Bandiera, S., Kelley,
M., Ryan, D.E., Daniel, R., McCluskey, S.A., Levin, W. and
Thomas, P.E.
Regulation of two members of the steroid-inducible cytochrome
P450 subfamily (3A) in rats.
Arch. Biochem. Biophys. 301, 345-354 (1993)
CYP3A2 rat
GenEMBL S45634 (1572bp)
PIR S27108 (36 amino acids)
Telhada,M.B., Pereira,T.M. and Lechner,M.C.
Effect of dexamethasone and phenobarbital on run-on transcription
rate and CYP3A mRNA concentration in rat liver: changes during
development
Arch. Biochem. Biophys. 298, 715-725 (1992)
CYP3A2 rat
UCSC Browser chromosome 12
9570862 MDLLSALTLETWVLLAVILVL 9570800
9570429 LYRLGTHRHGIFKKQGIPGPKPLPFLGTVLNYYK 9570328
9566707 GLGRFDMECYKKYGKIWG 9566654
9564529 LFDGQTPVFAIMDTEMIKNVLVKECFSVFTNRR 9564431
9559660 DFGPVGIMGKAVSVAKDEEWKRYRALLSPTFTSGRLKE 9559547
9559467 MFPIIEQYGDILVKYLKQEAETGKPVTMKK 9559378
9559082 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLRFDFFDPLFLSV 9558936
9556537 VLFPFLTPIYEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHK 9556409
9555511 HRVDFLQLMLNAHNNSKDEVSHK 9555443
ALSDVEIIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSK in a seq gap
9551883 APPTYDIVMEMEYLDMVLNETLRLYPIGNRLERVCKKDIELDGLFIPKG
SVVTIPTYALHHDPQHWPKPEEFHPE 9551659
9550394 RFSKENKGSIHPYVYLPFGNGPRNCIDMRFALMNMKLALTKVLQNFSFQPCKETQ 9550230
9547469 IPLKLSRQAILEPEKPIVLKVLPRDAVINGA 9547377
CYP3A3X human
PIR A25450 (504 amino acids) PIR A29410 (504 amino acids)
Molowa, D.T., Schuetz, E.G., Wrighton, S.A., Watkins, P.B.,
Kremers, P., Mendez-Picon, G., Parker, G.A. and Guzelian, P.S.
Complete cDNA sequence of a cytochrome P-450 inducible by
glucocorticoids in human liver.
Proc. Natl. Acad. Sci. U.S.A. 83, 5311-5315 (1986)
This number is discontinued the seq = CYP3A4
CYP3A4 human
GenEMBL D11131 (1345bp)
Hashimoto,H. Toide,K., Kitamura,R., Fujita,M., Tagawa,S.,
Kamataki,T. and Itoh, S.
Gene structure of CYP3A4 an adult-specific form of cytochrome
P450 in human
livers and its transcriptional control.
Eur. J. Biochem. 218, 585-595 (1993)
CYP3A4 human
GenEMBL J04449 (2849bp)
Bork,P., Muto,T., Beaune,P.H., Srivastava,P.K., Lloyd,R.S. and
Guengerich,F.P.
Characterization of mRNA species related to human liver cytochrome
P-450 nifedipine oxidase and the regulation of catalytic activity.
J. Biol. Chem. 264, 910-919 (1989)
nf-10 nifedipine oxidase (IIIA3)
CYP3A4 Pan troglodytes (chimp)
NM_001122775.1
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPL
PFLGNILSYRKGFCMFDMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREADTGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSIIVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI
DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLALIRVLQNFSFKPCKETQIPLKLRLGGLLQPEKPIVLKVESRDGTVSGA
CYP3A4 Macaca fasicularis (monkey)
Formerly CYP3A8 but
Renamed CYP3A4 to reflect orthology with human CYP3A4
GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
PIR S28168 (503 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL
PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI
DSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV
VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA
CYP3A4 Macaca fasicularis (monkey)
Formerly CYP3A8 but
Renamed CYP3A4 to reflect orthology with human CYP3A4
Swiss P25231 (22 amino acids)
Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and
Kamataki,T.
Biochim. Biophys. Acta 996, 142-145 (1989)
CYP3A4 Macaca fasicularis (monkey)
Formerly CYP3A8 but
Renamed CYP3A4 to reflect orthology with human CYP3A4
PIR S36875 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
CYP3A4 Macaca mulatta (rhesus monkey)
Formerly named CYP3A64
Analysis of the genomic DNA shows this gene is syntenic with
human CYP3A4 so it has been renamed CYP3A4
NM_001040414
Tom Rushmore, Merck & Co. Inc.
Submitted to nomenclature committee 6/30/2003
92% to CYP3A4
MDLIPDLAVETWLLLAVTLVLLYLYGTHSHGLFKKLGIPGPTPL
PLLGNILSYRKGFWTFDMECYKKYGKVWGFYDGRQPVLAITDPNMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAKYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDP
FFLSITIFPFIIPILEVLNISIFPREVTSFLRKSVKRIKESRLKDTQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDTVLPNKAPPTYDTVLQMEYLDMVVNETLRIFPIAMRLERVCKKDVEINGIFIPKGV
VVMIPSYALHHDPKYWPEPEKFLPERFSKKNNDNIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKIESRDGTVSGA
CYP3A4 Macaca mulatta (rhesus monkey)
NP_001035504
UCSC Browser chr3:47026931-47056683 (-) strand
syntenic with CYP3A4 human
CYP3A4 Pongo pygmaeus (orangutan)
EF589794.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a4
93% to 3A4 human
LAMETWILLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPLLGNV
FSYRKGFWRFDMECHKKYGKVWGFYDGRQPVLAITDPDMIKTVLVKECYSVFTNRRPF
GPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIARYGDVLVRNLRREAET
GKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSII
VFPFLTPILEILNISVFPREVTSFLRKSVKRMKESRLKDTQKHRVDFLQLMIDSQNSK
ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQRKLQEEIDAVLP
NKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPS
YALHHDPKYWTEPGKFLPERFSKKNKDNIEPYVYTPFGTGPRNCIGMRFALMNMKLAV
IRVLQNFSFKPCKETQIPLKLRLGGLLQTEKPIVLKVESRDG
CYP3A4 Papio anubis (baboon)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
baboon3a4
93% to 3A4 human
CYP3A4 Callithrix jacchus (marmoset)
GenEMBL D31921
Igarishi, T.
Unpublished
Renamed CYP3A4 based on synteny and placement on phylogenetic trees
Formerly CYP3A21
CYP3A4-ie1b human = CYP3A4P1
GenEMBL NT_007933.10|Hs7_8090
alt exon 1 (partial)
24614522 LIPNLAVETWLLL 24614484
CYP3A4-ie1b Macaca mulatta (rhesus monkey)
UCSC browser chr3: 47055991-47055947 (-) strand
Ortholog of human CYP3A4-ie1b internal duplicate exon 1
47055991 MDLIPNLAMET*LLL 47055947
CYP3A4v1 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP3A4, 88% to human CYP3A7
CYP3A4v2 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
92% to human CYP3A4, 88% to human CYP3A7
1 aa diff to 3A4v1, 4 nuc. diffs
CYP3A4frag Tupaia belangeri (northern tree shrew)
AY699817
LMINSQNSKEMESHKALTDLELVAQSIIFIFAGYETTSSILSFI
MYTLAIHPDVQKKLQEEVDATFPNKAPPTYDALMQMEYLDMVVNEVLRLYPVAGRLER
VCKKDV
CYP3A4P1 human = CYP3A4-ie1b
GenEMBL NT_007933.10|Hs7_8090
alt exon 1 (partial)
24614522 LIPNLAVETWLLL 24614484
CYP3A5_v1 human
PIR A60558 (29 amino acids)
Wrighton, S.A., Ring, B.J., Watkins, P.B. and Vandenbranden, M.
Identification of a polymorphically expressed member of the
human cytochrome P-450III family.
Mol. Pharmacol. 36, 97-105 (1989)
CYP3A5_v1 human
GenEMBL S74699 (1526bp) S74700 (1667bp)
Jounaidi,Y., Guzelian,P.S., Maurel,P. and Vilarem,M.J.
Sequence of the 5'-flanking region of CYP3A5: comparative analysis
with CYP3A4 and CYP3A7.
Biochem. Biophys. Res. Commun. 205, 1741-1747 (1994)
CYP3A5_v1 human
GenEMBL AC005020 genomic sequence 13 exons
Same intron exon structure as CYP3A43 from human
CYP3A5-de1b2b human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7
alt exon 1 and 2 upstream of 3A5
239409 MDLIPNLAVETWLLLAVSLVLLYL
243605 YGAHSHGLFKKLGIPGPTPLLFLGTTLSYHQ 243697
CYP3A5-de13c human = CYP3A51P
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 detritus exon 13 upstream of 3A5
old name = 3A51P, note: this name is being used by the HGNC
254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
because the HGNC has strict rules for gene names,
The old names (CYP3A51P, etc.) are being used by the HGNC
These will be synonyms.
CYP3A5_v2 human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
formerly CYP3A5P1, new name = CYP3A5_v2 short for:
CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
14n, 15n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5-de1b2b3b14n4b15n Macaca mulatta (rhesus monkey)
between CYP3A7 and CYP3A5 there is a pseudogene
containing 6 exons, including the cryptic exons 14n and 15n
found in the human alt. splice form CYP3A5_v2
This pseudogene is syntenic with human CYP3A5_v2
But in humans the cryptic exons exist inside the 3A5 gene
not outside it. This suggests a deletion event happened in humans.
Loss of the first 4 exons in the ancestral 3A5 gene would make
The current human gene possible.
82% to CYP3A5_v2 alt splice from the CYP3A5 gene
MDLIPNLAVETWLLLAVSLVLLYL (2) exon 1
YGAHSHGLFKKLGIPGPTPLPFLGTTLSYRQ (0) exon 2
GLWKFDTECYKKYGKMWR (2) exon 3
SSLFGPHYPSSYEDLNDSYVRLLLCVTP**TRT*DCYALHNWG () cryptic exon 14n
YKGQQPVLAITDPNMTKTVLVKEYYSVFTNQR (0) exon 4
ICATTSMIKMQTHSITMWLPPAILQSQ cryptic exon 15n
CYP3A5_v3 human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
formerly CYP3A5P2, new name = CYP3A5_v3 short for:
CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
14n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5P1X human
GenEMBL L26985 (1599bp)
Schuetz,J.D.
unpublished (1994)
new name = CYP3A5_v2 short for:
CYP3A5-1a2a3a14n4a15n5a16nD6a7a8a9a10axD11aD12aD13a
14n, 15n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5P2X human
GenEMBL X90579 (?bp)
Maurel,P. and Jounaidi,Y.
unpublished (1995)
note: a second pseudogene similar to CYP3A5P1
new name = CYP3A5_v3 short for:
CYP3A5-1a2a3a14n4a5a16nD6a7a8a9a10axD11aD12aD13a
14n and 16n are cryptic exons, delta = deleted
exon 10ax means exon 10 is extended downstream
this is an alternative transcript not a pseudogene
CYP3A5 Pan troglodytes (chimp)
NM_001093777
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL
PLLGNVLSYRQGLWKFDTECYKKYGKMWGMYDGQLPVLAITDPDMIRTVLVKECYSVF
TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL
RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP
LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI
DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE
IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS
MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN
MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSGE
CYP3A5 Pan troglodytes (chimpanzee)
EF589798.1
99% (3 aa diffs) to human
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPL PLLGNVLSYRQGLWKFDTECYKKYGKMWGMYDGQLPVLAITDPDMIRTVLVKECYSVF TNRRSLGPVGFMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNL RREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDP LFLSIILFPFLTPVFEALNVSLFPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMI DSQNSKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKE IDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGS MVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMN MKLALIRVLQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGTLSG
CYP3A5 Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
name has been changed to indicate orthology formerly CYP3A66
CYP3A5 Macaca mulatta (rhesus monkey)
NM_001040219
MDLIPNLAMETWLLLAVSLVLLYLYGTRSYGLFKRQGIPGPTPL
PFLGNILSYRQGLWKFDTECYKKYGKMWRTQDGQLPVLTITDPEMIKTVLVKECYSVF
TNRRPLGPVGLMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDMLVRNL
RREAEKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPKDPFVESVKKFLKFDFLDP
LFLLTILFPFLTPAFEALNVSLFPKDAINFLNKSVNSMKKSRLNDKQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQKE
IDAVLPNKAPATYDAMVQMEYLDMVVNETLRLFPIAIRLERACKKDVEINGVFIPKGA
MVVIPTYALHHDPKYWTEPEEFRPERFSKKNKDSIDPYIYTPFGTGPRNCIGMRFALM
NMKLAIIKVLQNFSFKPCKETQIPLKLGNQGLLQSEKPIVLKVESRDGTLSGE
CYP3A5 Macaca fasicularis (cynomolgus monkey)
DQ074795
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A5_2-F5
3 aa diffs to 3A5 Macaca mulatta
MDLIPNLAMETWLLLAVSLVLLYLYGTRSYGLFKRQGIPGPTPL
PFLGNILSYRQGLWKFDTECYKKYGKMWRTQDGQLPVLTITDPDMIKTVLVKECYSVF
TNRRPLGPVGLMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDMLVRNL
RREAEKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPKDPFVESVKKFLKFDFLDP
LFLLTILFPFLIPAFEALNVSLFPKDAINFLNKSVNSMKKSRLNDKQKHRVDFLQLMI
DSQNSKETESHKALSDQELVAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKLQKE
IDAVLPNKAPATYDAMVQMEYLDMVVNETLRLFPIAIRLERACKKDVEINGVFIPKGA
MVVIPTYALHHDPKYWTEPEEFRPERFSKKNKDSIDPYIYTPFGSGPRNCIGMRFALM
NMKLAIIKVLQNFSFKPCKETQIPLKLGNQGLLQSEKPIVLKVESRDGTLSGE
CYP3A5 Macaca fasicularis (cynomolgus monkey)
No accession number
Wu Zhicong
Submitted to nomenclature committee 10/30/2006
91% to 3A5 human, 84% to 3A4, 80% to 3A7, 75% to 3A43
100% identical to Unos seq.
CYP3A5 Callithrix jacchus (marmoset)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Cja3a5b
89% to 3A5 human, probable ortholog of CYP3A5
note: there is a second gene CYP3A90 that is 95% identical to this
it is a paralog of the CYP3A5 gene
CYP3A5 Pongo pygmaeus (orangutan)
EF589795.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a5
98% to 3A5 human
WLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQ
GLWKFDTECYKKYGKMWGTYDGQLPVLAITDPDMIKTVLVKECYSVFTNRRSLGPVGF
MKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVT
LKDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFSFLDPLFLSIILFPFL
TPVFEALNVSLFPKDTINFLNKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESH
KALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPP
TYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGAMVVIPTYALHH
DPKYWTEPEEFRPERFSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQN
FSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRDGE
CYP3A6 rabbit
GenEMBL J05034, M19139
CYP3A7 human
NM_000765
MDLIPNLAVETWLLLAVSLILLYL
YGTRTHGLFKKLGIPGPTPL
PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF
TNRRPFGPVGFMKNAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDP
FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI
DSQNSKDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE
IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV
NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
CYP3A7-de1b2b human
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 alt exon 1 and 2 upstream of 3A7
186958 xxLIPNLAVETWLLLAVSLVLHYL + ex 1
191087 VSLCRYETHSHGLFKNLGIPGPRPLLFLGTTLSYHQ 191194 + ex 2
CYP3A7 Pan troglodytes (chimp)
UCSC genome browser chr7:100320611-100350193
3 aa diffs to human
MDLIPNLAVETWLLLAVSLILLYL YGTRTHGLFKKLGIPGPTPL PFLGNALSFRKGYWTFDMECYKKYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVF TNRRPFGPVGFMKSAISIAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL RREAETGKPVTLKHVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNPLDP FVLSIKVFPFLTPILEALNITVFPRKVISFLTKSVKQIKEGRLKETQKHRVDFLQLMI DSQNSEDSETHKALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKE IDTVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALV NMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEKPIVLKAESRDETVSGA
CYP3A7 Cercopithecus aethiops (African green monkey)
No accession number
Catherine Booth-Genthe
Merck Research laboratories
89% to human CYP3A7, 89% to human CYP3A4
82% to human 3A5 and 73% to 3A43
note: this seq is equally similar to 3A7 and 3A4
but there is another seq with a better match to
3A4 in African green monkey, so this must be
the 3A7 ortholog
CYP3A7 Pongo pygmaeus (orangutan)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a7
96% to 3A7 human
CYP3A7 Papio anubis (baboon)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
baboon3a7-like
92% to 3A7 human
CYP3A7 Macaca mulatta (rhesus monkey)
AANU01101873.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mmul3a7-like
UCSC browser chr3:46903541-46929928 (-) syntenic with CYP3A7
91% to CYP3A7 human, 88% to CYP3A4, 82% to CYP3A5
24981 MDLIPDLAVETWLPLAVSLILLYL
YGTHSHGLFKKLGIPGPTPLPFFGNVLSFRK 29288
34310 GFWTFDMECYKKYRKVWG 34363
35908 FYDCRQPVLAITDPNMIKTVLVKECYSVFTNRR 36006
38516 PLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKE 38629
38894 MVPIIAQYGDVLVRNLRREAETGKPVTLKD 38983
40270 VFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDPFFLSIK 40416
41507 IFPFLTPIFEALNITVFPRKVTRFLRKSVKRMKEGRLKETQK 41632
42652 RRVDFLQLMIDSQNSKDTESHK 42717
45311 VLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKEIDTVLPNK 45472
46900 APPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGVVVMIP
47094
47095 SYVLHHDPKYWTEPEKFLPER
48220 RFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQ 48384
51270 IPLKLSFGGLLKTEKPIVLTAESRDGTVSGA* 51371
CYP3A7 Macaca fascicularis (cynomolgus monkey)
AB206123
MDLIPDLAVETWLPLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFFGNVLSFRKGFWTFDMECYKKYRKVWGFYDCRQPVLAITDPNMIKTVLVKECYSVF
TNRRPLGPVGFMKSAITVAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREAETGKPVTLKDVFGAYSMDVITSTSFGVNVDSLNNPQDPFVENTKKLLRFNSLDP
FFLSIKIFPFLTPIFEALNITVFPRKVTSFLRKSVKRIKEGRLKETQKRRVDFLQLMI
DSQNSKDTASHKVLSDLELMAQSIMFIFAGYETTSSVLSFIIYELATHPDVQQKLQKE
IDTVLPNKAPPTYDTMLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMSIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKLALIRVLQNFSFKPCKETQIPLKLSFGGLLKTEKPIVLTAESRDGTVSGA
CYP3A8X Macaca fasicularis (monkey)
Renamed CYP3A4 to reflect orthology with human CYP3A4
GenEMBL S53047 (2032bp) Swiss P33268 (503 amino acids)
PIR S28168 (503 amino acids)
Komori,M., Kikuchi,O., Sakuma,T., Funaki,J., Kitada,M.
and Kamataki,T.
Molecular cloning of monkey liver cytochrome P-450 cDNAs:
similarity of the primary sequences to human cytochromes P-450.
Biochim. Biophys. Acta 1171, 141-146 (1992)
CYP3A8X Macaca fasicularis (monkey)
Renamed CYP3A4 to reflect orthology with human CYP3A4
Swiss P25231 (22 amino acids)
Ohta,K., Kitada,M., Hashizume,T., Komori M., Ohi,H., and
Kamataki,T.
Biochim. Biophys. Acta 996, 142-145 (1989)
CYP3A8X Macaca fasicularis (monkey)
Renamed CYP3A4 to reflect orthology with human CYP3A4
PIR S36875 (13 amino acids)
Ohmori, S., Horie, T., Guengerich, F.P., Kiuchi, M.and Kitada,M.
Purification and characterization of two forms of hepatic microsomal
cytochrome P450 from untreated cynomolgus monkeys.
Arch. Biochem. Biophys. 305, 405-413 (1993)
CYP3A9 rat
GenEMBL U46118(2101bp)
Wang,H., Kawashima,H. and Strobel,H.W.
cDNA cloning of a novel CYP3A from rat brain
Biochem. Biophys. Res. Commun. 221 (1), 157-162 (1996)
CYP3A9 rat
GenEMBL U60085(1882bp)
Nef,P.
Hepatic expression and inducibilty of CYP3A9 and other members of
the rat CYP3A subfamily.
unpublished (1996)
CYP3A9 rat
UCSC Browser chromosome 12
some frameshifts in genome seq of exon 8
17153442 MDLIPNFSMETWLLLVISLVLLYL 17153513
17155488 YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK 17155580
17156990 GFWEFDKYCHKKYGKLWG 17157043
17159222 LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17159320
17163193 NFGPVGILKKAISISEDEEWKRIRALLSPTFTSGKLKE 17163306
17163523 MFPIINQYTDMLVRNMRQGSEEGKPTSMKD 17163606
17165013 IFGAYSMDVITATSFGVNVDSLNNPQDPFVEKVKKLLKFDIFDPLFLSV 17165159
17168128 TLFPFLTPLFEALNVSMFPRDVIDFFKTSVERMKE 17168226 NRMKEKEK
17170690 QRMDFLQLMINSQNSKVKDSHK 17170755
17177660 ALSDVEIVAQSVIFIFAGYETTSSALSFVLYLLAIHPDIQKKLQDEIDAALPNK 17177821
17179040 AHATYDTLLQMEYLDMVVNETLRLYPIAGRLERVCKTDVEINGVFIPKGT
VVMIPTFALHKDPHYWPEPEEFRPE 17179264
17191573 RFSKKNQDNINPYMYLPFGNGPRNCIGMRFALMNMKVALVRVLQNFSFQPCKET 17191734
17192800 QIPLKLSKQGLLQPEKPLLLKVVSRDETVNGA 17192895
CYP3A9-se1[4]X rat
UCSC Browser chromosome 12
Note: the revised genome probably has this as part of Cyp3a62
Discontinued name
17387311 LYEGRQPVLAITDPDIIKTVLVKECYSTFTNRR 17387213 exon 4
CYP3A9-se1[1:2:4] rat
193 kb downstream of Cyp3a9 on opposite strand
100% match to Cyp3a9
MDLIPNFSMETWLLLVISLVLLYL
YGTHSHGIFKKLGIPGPKPLPFLGTILAYRK
LYDGRQPVLAITDPDIIKTVLVKECYSTFTNRR
CYP3A10 hamster
GenEMBL M73992 (2015bp)
Miyata,M., Nagata, K., Yamazoe,Y. and Kato,R.
Nucleotide and deduced amino acid sequence of a new rat CYP3A form
unpublished (1993)
Cyp3a11 mouse
PIR A60564 (24 amino acids)
Bornheim, L.M. and Correia, M.A.
Purification and characterization of a mouse liver cytochrome
P-450 induced by cannabidiol.
Mol. Pharmacol. 36, 377-383 (1989)
Cyp3a11 mouse
GenEMBL X60452, AC111090.20 genomic clone (seq shown)
104114 MDLVSALSLETWVLLAISLVLLYR 104185
106160 YGTRKHELFKKQGIPGPKPLPFLGTVLNYYK 106252
108416 GLWKFDMECYKKYGKTWG 108469
110360 LFDGQTPLLAVTDPETIKNVLVKECFSVFTNRR 110458
114653 DFGPVGIMSKAISISKDDEWKRYRALLSPTFTSGKLKE 114766
114846 MFPVIEQYGDILVKYLRQKAKKGKPVTMKD 114935
115207 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEKAKKLLRFDFFDPLLFSV 115353
117878 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVDRMKESRLDSKQK 118006
118896 HRVDFLQLMMNSHNNSKDKVSHK 118964
121382 ALSDMEITAQSIIFIFAGYETTSSTLSFTLHSLATHPDIQKKLQDEIDEALPNK 121543
123352 APPTYDTVMEMEYLDMVLNETLRLYPIANRLERVCKKDVELNGVYIPKGSTVMIPSYALH
HDPQHWSEPEEFQPER 123579
125008 FSKENKGSIDPYVYLPFGNGPRNCLGMRFALMNMKLALTKIMQNFSFQPCKETQ 125169
128728 IPLKLSRQGLLQPEKPIVLKVVPRDAVITGA 128820
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a11-de12bX mouse
old name Cyp3a-se11[12] also = Cyp3a-se6[12]
this fragment has joined with Cyp3a44-de9b10b11b
to make Cyp3a44-de9b10b11b12b (see below)
137165 RFSMENKGSIDPY 137127
137122 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 136997
CYP3A12 dog
PIR S04341 (28 amino acids)
Ciaccio, P.J. and Halpert, J.R.
Characterization of a phenobarbital-inducible dog liver
cytochrome P450 structurally related to rat and human
enzymes of the P450IIIA (steroid-inducible) gene subfamily.
Arch. Biochem. Biophys. 271, 284-299 (1989)
Cyp3a13 mouse
GenEMBL X63023(1881bp) also NT_039315.1
Yanagimoto,T., Itoh,S., Sawada,M., Hashimoto,H. and Kamataki,T.
Molecular cloning and functional expression of a mouse cytochrome
P-450 (Cyp3a-13): examination of Cyp3a-13 enzyme to activate
aflatoxin B1 (AFB1).
Biochim. Biophys. Acta 1201 (3), 405-410 (1994)
CYP3A14 Cavia cobaya (guinea pig)
GenEMBL D16363 (1827bp)
Mori,T., Itoh,S. and Kamataki,T.
cDNA and deduced amino acid sequence of a novel cytochrome
P450 from male guinea pig liver mRNA with high homology to
CYP3a family
unpublished (1993)
CYP3A14 Cavia porcellus (guinea pig)
GenEMBL D49731 (2321bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
CYP3A15 Cavia cobaya (guinea pig)
GenEMBL D26487 (2163bp)
Mori,T., Itoh,S. and Kamataki,T.
Differential effects of ascorbic acid deficiency on the expression
of the forms of cytochrome P450.
Unpublished (1995)
Cyp3a16 mouse
GenEMBL D26137 (1701bp) also NT_039318
Itoh,K., Satoh,M., Abe,Y., Hashimoto,H., Ynagimoto,T. and Kamataki T.
A novel form of mouse cytochrome P450 3A (Cyp3a16). Its cDNA cloning
and expression in fetal liver.
Eur. J. Biochem. 226, 877-882 (1994)
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a16-de12b mouse
GenEMBL NT_039318 - strand
detritus exon 12
z in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1616751 GPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1616647
CYP3A17 guinea pig
GenEMBL D28515
Mori,T.
submitted to Nomenclature Committee
Not in Genbank as of 6/26/95
CYP3A18 rat
no accession number
Kiyoshi Nagata
6-beta-C
submitted to Nomenclature Committee
CYP3A18 rat
GenEMBL X79991 (2005bp)
Strotkamp,D., Roos,P.H. and Hanstein,W.G.
A novel CYP3 from female rats.
Biochim. Biophys. Acta 1260, 341-344 (1994)
CYP3A18 rat
GenEMBL D38381 (?bp) (not in GenBank yet,1/30/97)
Yamazoe,Y. et al.
Isolation and characterization of of a new rat P450 (CYP3A18) cDNA
encoding P4506b-2 catalyzing testosterone 6b- and 16a-hydroxylations.
Pharmacogenetics in press (1995)
CYP3A18 rat
UCSC Browser chromosome 12
9166475 MEIIPNLSIETWVLLATSLMLFYI 9166404
9156355 YGTYSHGLFKKLGIPGPKPVPLFGTIFNYGD 9156263
9143764 GMWKFDDDCYKKYGKIWG 9143711
9141173 FYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRR 9141075
9137566 CFGPMGFMKKAITMSEDEEWKRLRTILSPTFTSGKLKE 9137453
9136038 MFPLMRQYGDTLLKNLRREEAKGEPINMKD 9135949
9135719 IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSV 9135573
9133657 VLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKTMKKNRLDSNQK 9133529
9132027 NRVDFLQLMMNTQNSKGQESQK 9131965
9129047 ALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNK 9128886
9126077 APVTYDALMEMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGT
VVTIPIYPLHRNPEYWLEPEEFNPE 9125853
9120566 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT 9120405
9117192 QIPLKISRQPIFQPEGPIILKLVSRD 9117115
CYP3A18-se1[5:6:7:8] rat
UCSC Browser chromosome 12
64% to 3A18
9216052 FGPVGFMKKAVTISEDDEGKRLRPLLSPVFTSGK 9216153
9216386 LWLLHFGLMCSPSSGSVMSVKHLRQEEKGEPIHMKE 9216493
9216722 FSGAYSMNGIAGASFGVNVDSLNN 9216781
XXXXXXXXXXXXXXXXXXXXXXXX
VVLFPFLTQI
CYP3A19 Capra hircus (goat)
GenEMBL X76503 (1084bp)
Zeilmaker,W.M., Van 't Klooster,G.A.E., Gremmels-Gehrmann,F.J.,
Van Miert,A.S.J.P.A. and Horbach,G.J.M.J.
cDNA and deduced amino acid sequence of a dwarf goat liver
cytochrome P450-fragment belonging to the CYP2C gene subfamily
Biochem. Biophys. Res. Commun. 200, 120-125 (1994)
C-terminal fragment from I-helix to end
CYP3A20 Guinea pig
GenEMBL
T. Mori
unpublished
CYP3A21X Callithrix jacchus (marmoset)
GenEMBL D31921
Igarishi, T.
Unpublished
Renamed CYP3A4 based on synteny and placement on phylogenetic trees
CYP3A22v1 Miniature pig
GenEMBL AB006010
Sakuma,T., Shimojima,T., Miwa,K. and Kamataki,T.
Cloning CYP2D21 and CYP3A22 cDNAs from liver of miniature pigs
Drug Metab. Disp. 32, 376-378 (2004)
CYP3A22v2 Sus scrofa (pig)
AK233355
Uenishi,H., Eguchi,T., Suzuki,K., Sawazaki,T., Toki,D., Shinkai,H.,
Okumura,N., Hamasima,N. and Awata,T.
PEDE (Pig EST Data Explorer): construction of a database for ESTs
derived from porcine full-length cDNA libraries
Nucleic Acids Res. 32 (DATABASE ISSUE), D484-D488 (2004)
This seq has 8 aa diffs to CYP3A22 and is an exact match to the
hybrid seq CYP3A46v2 last 61 aa
MDLIPSFSVETWL
LLATSLVLLYLYGTYSHGLFKKLGIPGPKPLPYFGSVLEYRKGMWHFDNKCFKKYGKMWG
FYDGRQPVLAMRDPEMIKAVLVKECYSAFTNRRNFGPAGVMKNAISVAKDEQWKRVRTLL
SPTFTSGKLKEMFPIIAQYGDMLVRNLRKEAEKGNSINTKEIFGAYSMDVITSTAFGVNV
DSLNNPRGPFVQYARKLLRFDFLDPFILSIILFPFLSPFFEVLDITLFPRSSAKFFTQSV
KRMKESRLKDQQMRRVDLLQLMINSQNSKETDAHKALSDQELVAQSIIFIFAGYETTSSS
LSFLAYILATHPDVQQKLQEEIDATFPSKALPSYDSLAQMEYLDMVVNEILRLYPIAARL
ERVCKKDVEIHGVSVPKGTVMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDTINPYTYL
PFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKV
VPRDGTVSGA
CYP3A23 rat
GenEMBL D13912
Kirita,S. and Matsubara,T.
Cloning and characterization of a novel member of steroid induced
cytochrome P450 3A in rats.
Arch. Biochem. Biophys. 307, 253-258 (1993)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A23 rat
GenEMBL D29967
Komori,M. and Oda,Y.
A major glucocorticoid inducible P450 in rat liver is not P4503A1
J. Biochem. 116, 114-120 (1994)
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
CYP3A23 rat
UCSC Browser chromosome 12
Note: 3A1 and 3A23 are the same gene. 3A23 is the accurate seq.
9625823 MDLLSALTLETWVLLAVVLVLLY 9625755
9623782 GFGTRTHGLFKKQGIPGPKPLPFFGTVLNYYM 9623687
9621110 GLWKFDVECHKKYGKIWG 9621057
9617991 LFDGQMPLFAITDTEMIKNVLVKECFSVFTNRR 9617893
9616272 DFGPVGIMGKAISVSKDEEWKRYRALLSPTFTSGRLKE 9616159
9616079 MFPVIEQYGDILVKYLRQEKGKPVPVKE 9615996
9615715 VFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSV 9615569
9614012 VLFPFLTPVYEMLNICMFPKDSIEFFKKFVYRMKETRLDS 9613893
9613004 VQKHRVDFLQLMMNAHNDSKDKESHT 9612936
9607896 ALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNK 9607735
9605981 APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKG
SVVMIPSYALHRDPQHWPEPEEFRPE 9605757
9604349 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET 9604188
9597247 QIPLKLSRQGLLQPTKPIILKVVPRDEIITGS 9597152
CYP3A24 sheep
GenEMBL U59378(1653bp)
Ching,M.S., Chun-Jing,J., Ghabrial,H., Wookey,P.J., Smallwood,R.A.
and Morgan,D.J.
Ovine foetal liver CYP3A24
unpublished (1996)
Cyp3a25 mouse
GenEMBL AF204959
Dai,D., Bai,R., Hodgson,E. and Rose,R.L.
submitted to Nomenclature Committee 10/18/96
Cloning, sequencing, heterologous expression and characterization
of murine Cytochrome P450 3A25, a 6B-Testosterone hydroxylase
Unpublished
MELIPNLSIETWVLLVTSLVLFYI
YGTYSHGLFKKLGIPGPKPLPLLGTIFNYYD
GMWKFDEDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
FFGPVGFMKKAITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPISMKD
IFGAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILKFKVFDPFLLS
IILFPFLTPIYEMLNFSIFPRDSMNFFKKFVKRMKKERLASNQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ
IPLKISREPIFQPEKPIILKVVSRDKPRTGS
Cyp3a25 mouse
GenEMBL Y11995
Mahnke,A., Roos,P. and Hanstein,W.G.
one amino acid difference with Roses sequence at amino acid 215
unpublished
Cyp3a25 mouse
GenEMBL AC111090.20 genomic clone
Last two exons. This clone also contains CYP3a11, Cyp3a44 and the
region between them. This helps to close the gap in the 3a cluster
shown in Fig 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
2345 FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQ 2506
6188 IPLKISREPIFQPEKPIILKVVSRDKPRTGS 6280
Cyp3a25-de8b9b12b mouse
GenEMBL AC111090.20 genomic clone
r in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
27841 PVFFSFLIPI*EMLNISVFQKGSIAFFKKFVDRMNESRPDSKQK 27710
18903 DLVGFLQPMINAHNNPKDKESHNG 18832
15460 XXXXXXGSID-YVYLSFGNGPRIYIGVRFTLMNMKVLTLTKVLHNFSFHPCKET* 15317
Cyp3a25-de11c mouse
GenEMBL NT_039324.1 - strand
detritus exon 11
q in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
168333 XPVTLGTLVEIEYPDMVVT*ILILYPIGNRPESVCKEGFEVFIPKGTRVTVPTFALH*DPQYWPELEKXXXXX 168133
CYP3A26 dog
no accession number
David Fraser
submitted to Nomenclature Committee
95.6% identical to 3A12 from dog
CYP3A27 Oncorhynchus mykiss (rainbow trout)
GenEMBL U96077
Don R. Buhler
Arch. Biochem. Biophys. 360, 000-000 (1998) in press
56% identical to 3A12
CYP3A28 Bos taurus (cow)
GenEMBL Y10214(1870bp)
Natsuhori,M., van Raak,M., Ligtenberg,M., Kleij,L., ten Berge,D.,
Zweers-Zeilmaker,W.M., de Groene,E.M., Van Miert,A.S.J.P.A.,
Witkamp,R.F. and Horbach,G.J.
Isolation of a full length cytochrome P450 (CYP3A) cDNA sequence
and its functional expression in V79 cells.
unpublished (1997)
CYP3A28 Bos taurus (cow)
See cattle page for details
MELIPSFSMETWVLLATSLVLLYI (2)
YGTYSYGLFKKLGIPGPRPVPYFGSTMAYHK (0)
GIPEFDNQCFKKYGKMWG (2)
FYEGRQPMLAITDPDIIKTVLVKECYSVFTNRR (0)
IFGPMGIMKYAISLAWDEQWKRIRTLLSPAFTSGKLKE (0)
MFPIIGQYGDMLVRNLRKEAEKGNPVNMKD (2)
MFGAYSMDVITGTAFGVNIDSLNNPHDPFVEHSKNLLRFRPFDPFILSI (1)
ILFPFLNPVFEILNITLFPKSTVDFFTKSVKKIKESRLTDKQM (0)
NRVDLLQLMINSQNSKEIDNHK (1)
ALSDIELVAQSTIFIFGGYETTSSTLSFIIYELTTHPHVQQKLQEEIDATFPNK (0)
APPTYDALVQMEYLDMVVNETLRMFPIAGRLERVCKKDVEIHGVTIPKGTTVLVPLFVLHNNPELWPEPEEFRPER (2)
FSKNNKDSINPYVYLPFGTGPRNCLGMRFAIMNIKLALVRILQNFSFKPCKETQ (0)
IPLKLYTQGLTQPEQPVILKVVPRGLGPQVEPDFL*
CYP3A29v1 pig
GenEMBL Z93099 (2015bp)
Nissen,P.H., Winteroe,A.K. and Fredholm,M.
Characterization and mapping of three porcine genes belonging to
the cytochrome P450 superfamily
Unpublished
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGVYDGRQPLLAVTDPNMIKSVLVKECYSVF
TNRRSFGPLGAMRNALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNIDSLNNPQDPFVENSKKLLKFSFFDP
FLLSLIFFPFLTPIFEVLNITLFPKSSVNFFTKSVKRMKESRLTDQQKRRVDLLQLMI
NSQNSKEMDPHKSLSNEELVAQGIIFIFAGYETTSSALSLLAYELATHPDVQQKLQEE
IEATFPNKAPPTYDALAQMEYLDMVVNETLRLYPIAARLERACKKDVEIHGVFVPKGT
VVVVPVFVLHRDPDLWPEPEEFRPERFSKKHKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQIPLKLTTQGLTQPEKPVVLKILPRDGTVSGA
CYP3A29v2 Sus scrofa (pig)
GenEMBL AB052260
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
2 amino acid diffs with 3A29v1
clone name 3Ac9
CYP3A29v3 Sus scrofa (pig)
GenEMBL AB052261
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1
clone name 3Ac16
CYP3A29v4 Sus scrofa (pig)
GenEMBL AB052262
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A29v1, 2 aa diffs with 3A29v3
clone name 3Ac25
CYP3A29v5 Sus scrofa (mini pig)
GenEMBL AF424780
Soucek,P., Zuber,R., Anzenbacherova,E., Linka,M. and Anzenbacher,P.
cDNA of minipig cytochrome P450 3A
Unpublished
75% to 3A4 human 98% to 3A29v1 8 diffs.
3 diffs with 3A29v3 and v4 (Partial seqs from 99-328)
4 diffs with 329v2 (Partial seq from 99-328)
CYP3A30 Fundulus heteroclitus
Genbank AF105068
Malin Celander and John J. Stegeman
Isolation of a cytochrome P450 3A cDNA sequence (CYP3A30) from the
marine teleost Fundulus heteroclitus and phylogenetic analyses of CYP3A
genes.
Biochem. Biophys. Res. Commun. 236, 306-312 (1997)
MGYFYLTAETWTLLVAFVTLLLVYAYWPYGTFKRLGISGPKPVP
FFGTMLHYRRGFFTFDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFT
NRRNFRLNGPLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMK
KKADKDEPLDLKEFFGSYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPL
FLAVAFFPFLGPILEKFELSFFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMID
SQKNSGAQQDKSLTDHEILSQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEI
DATFPNKAPVHYQPLMEMEYLDCVINESLRLFPIAARLERVAKAAVEINGVVIPKDMV
VMIPTWPLHRDPEIWPEPEAFKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVL
IKLAVVEILQQYSFSVCKETEVPFEMDIQGLLAPKRPIQLKLVPRS
CYP3A31 Syrian hamster
GenEMBL D86951
Alabouch,S., Kurose,K., Tohkin,M., Bani,M.H., Fukuhara,M.,
Nagata,K. and Yamazoe,Y.
cDNA cloning and expression of a novel CYP3A from the Syrian
hamster, CYP3A31
Biochim. Biophys. Acta 1397, 9-13 (1998)
clone name P450SH3A-1
CYP3A32 Balaenoptera acutorostrata (Minke whale)
AB014349
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
VITGIAFGVNIDSLNNPQDPFVEYSKKILKFNLLSPLLLSIVLF
PFLTPVFEALNITLFPKSSLNFLTKSVKRIKESRLKDKQTHRVDFLQLMINSQNSKET
DTHKVLSDTELMAQSIIFIFAGYETTSNSLSFIIYELATHPDVQQKLQEEIDATFPNK
APPTYEALVQ
CYP3A33 Phocoenoides dalli (Dall's porpoise)
no accession number
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
CYP3A34 Eumetopias jubatus (Steller sea lion)
AB014351
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
VITSTSFGVNIDSLNNPQDPFVENTKKLLKFDFLNPFLFSLLLF
PFLAPVFEMLNIWLFPKRVTDFFTKSVQRMKESRLKDKQKHRVDFLQLMINSQNSKEV
NTHKTLSDLELVAQSIIFIFAGYETTSTSLSFLVYELATHPDVQQKLQEEIDATFPNK
ALPTYDALLQ
CYP3A35 Phoca largha (Spotted seal)
AB014352
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
VITSTSFGVNIDSLNNPQDPFVENIKNFLKFDFLDPLFFSMLLF
PFLIPVFEKLNISLFPKSVTDFFMKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEI
DTYKALSDLELVAQSIIFIIAGYETTSTSLSFLVYELATHPDVQQKLQEEIDVTFPNK
ALPTYDALLQ
CYP3A36 Phoca fasciata (Ribbon seal)
AB014353
Ikuko Teramitsu, Yukio Yamamoto, and Shoichi Fujita
submitted to nomenclature committee 5/15/98
VITSTSFGVNIDSLNNPQDPFVENIKNFLKFDFLDPLFFSMLLF
PFLIPVFEKLNISLFPKSVTDFFMKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEI
DTYKALSDLELVAQSIIFIIAGYETTSTSLSFLVYELATHPDVQQKLQEEIDATFPNK
ALPTYDALLQ
CYP3A37 Gallus gallus (chicken)
no accession number
Manuel Baader and Urs Meyer
submitted to nomencalture committee
60% identical to mammalian CYP3A sequences
CYP3A37 Gallus gallus (chicken)
GenEMBL NM_001001751.1
Note: chicken has two CYP3As about 25kb apart on chr 14
These two genes are in the same location as human
Pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
See CYP3A80
MNFLPFFSIETWIILLIFVVLLIIYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLDFDTECFQKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRTDLAGVLRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKYFGEMLVKNI
QKRVEKNSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
VFILSFVCPFLTPLMAKMNISFFPSDAVDFFMRSIDKIKKDRERETHTGRVDFLQMMI
ESQKSDSNGSSDAKHSYKALSDIEVLSQAFIFIFAGYEPTSNTLGYLAYQLALHPDVQ
QKVVNEIDTILPNKAPLTYEAIMQLEYLDMAVNETLRLYPLGGRLERTCKRDVEINGV
TIPKGTIVIIPPYTLHRSPEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIG
MRFALLTLKVAITAVLQHFTFQVCKETQIPLKLQSLGLTTPEKPIVLKLVPRTNTAKA
CYP3A37 Meleagris gallopavo (turkey)
DQ450083
Shirley Yip, Roger Coulombe, Jr.
Submitted to nomenclature committee Jan. 20, 2006
Clone name CYP3A-F4
92% to chicken 3A37 probable ortholog
MNLLPFFSIETWILLLIFVALLIAYGTWPFGLFKKLGIPGPRPL
PFFGTCLEYRKGFLEFDTECFKKYGKIWGIYDGRQPAVVVMDPQIIKTVLVKECYSTF
TNRRRVDLAGELRNAVSLAEDDQWKRLRTVLSPTFTSGKLKEMFPTMKHFGEMLVKNV
QKRVEKDSSVPVKDFFGSYSMDVVTSTSFGVNIDSMNNPKSPFVREMQKLTKFDFFDP
LFILAFVCPFLTPLMAKMNVSFFPSDAVDFFLRSIDKIKKDREKETHKGRVDFLQMMI
ESQKSDSDGKNSHKALSDIEVLSQAFIFIFAGYEPTSNTLCYLAYLLALHPDVQQKVV
NEIDTILPNKAPLTYEAIMQLDYLDMAVNETLRLYPLGGRIERTCKKDVEINGVTIPK
ETIVVIPPYTLHRNSEYWPNPEEFRPERFSKENKDNIDPYTYLPFGAGPRNCIGMRFA
LLTLKVAITSILQHFTFQVCKETQIPLKLLSMGLMTPEKPIILKLVPRTNNAKA
CYP3A37 Struthio camelus (ostrich)
No accesion number
Yusuke Kawai
Submitted to nomenclature committee May 2, 2013
79% to CYP3A37 chicken
79% to CYP2AF1 Meleagris gallopavo (turkey)
CYP3A37 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_1137:6582-24650,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca4.
69% to CYP3A37 chick (ortholog), 64% to CYP3A113,
63% to CYP3A98 dog, 63% to 3A80 chicken
MELLPSFSIETWSFLVVLLGLLLLYGIWPFGVFGKLGIPGPRPWPFLGTLLQYRKGFVKFDSWCFQKYGRIWGIYDGRQPVM
AILDPAIIKTVLVKECYTTFTNRRNFGATGVLKSAISLAEDEHWKRVRTVLSPTFTSGKLKEMFPIIKHYGEALMRNVQKKV
DMDEPLVVKDVFGAYAMDVVTSTSFGVNIDSMNNPKDPFVKEIQKLTKFRSFDPRIILLFTFPILRTVFEALNIQIFSAEAV
DFFTRSFAKMKAGRAGETKEGRVDFLQLMIDSQTSNGHHQSNGIDHTYKGLTDDEILAQAFIFVFAGYEPTSNSLGYMAYML
ATHPDVQQKLQDEIDSVLPNKAPLTYDAIMQLEYLDMVLNETQRLYPLGGRIERVCKKDVEINGVTIPKGVVVMIPPYNLHR
DQEYWPEPEEFRPERFSKENKESVDPYTYLPFGAGPRNCIGMRFALVTMKVAITILLQHFSFRVCKETPIPLELSSQAFLVP
EKPIVLKLVRRNNLQ
CYP3A38 Medaka (fish)
no accession number
Seth Kullman
submitted to nomenclature committee 11/6/98
72% identical to CYP3A27 trout
CYP3A39v1 Sus scrofa (pig)
GenEMBL AF109068, NM_214422
Schuetz,E., Andag,R., Wieland,E. and Oellerich,M.
Porcine Cytochrome-P450 with high protein homology to human CYP3A4
(Nifedipine oxidase J04449)
Unpublished
88% identical to 3A29
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRTALSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNTDFLNNPQDPFVENSKKLLKFSFFSP
LFLSIIFFPFLTPILEVLNVTLFPKSVVNFFMRSIKRMKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKGLSDEELVAQGVFFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPSKALPSYDALAQMEYLDMVVNEILRLYPIAARLERVCKKDVEIHGVSVPKGT
VMMVPVFSIHRDPELWPEPEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCKETQTPLKLSSQGLIQPEKPILLKVVPRDGTVGGA
CYP3A39v2 Sus scrofa (pig)
GenEMBL AB052263
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
3 amino acid diffs with 3A39v1, 1 aa diff with 3A39v3
clone name 3Ac13
CYP3A39v2 Sus scrofa (pig)
Be aware that there is a sequence in Genbank called CYP3A39v2
With accession number EF625354
This sequence is really CYP3A46v3
with one amino acid difference to CYP3A46
CYP3A39v3 Sus scrofa (pig)
GenEMBL AB052264
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
1 amino acid diff with 3A39v2, 2 aa diffs with 3A39v1
clone name 3Ac19
CYP3A39v4 Sus scrofa (pig)
GenEMBL AB052265
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
4 aa diffs with 3A39v3, 6 aa diffs with 3A39v1
clone name 3Ac32
CYP3A39v5 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence with frameshifts before I-helix
95% to CYP39A1v1 NM_214422
only 2 aa diffs in first 193 aa
CYP3A40 medaka
no accession number
Seth Kullman
submitted to nomenclature committee 1/12/99
90% identical to CYP3A38 trout
Cyp3a41 mouse
GenEMBL NM_017396 AB033414
Sakuma,T., Takai,M., Endo,Y., Kuroiwa,M., Ohara,A., Jarukamjorn,K.,
Honma,R. and Nemoto,N.A novel female-specific member of the CYP3A gene
subfamily in the mouse liver
Arch. Biochem. Biophys. 377 (1), 153-162 (2000)
91% identical to 3a11 87% identical to 3a16 69% to 3a25 and
68% to 3a13 90% to 3a44
submitted to nomenclature committee 6/1/99
MNLFSALSLDTWVLLAIILVLLYR
YGTRTHGLFKKQGIPGPTPLPFLGTVLNYYK
GLWKFDMECYEKYGKTWG
LFDGQMPLFVITDPEMIKNVLVKECFSVFTNRR
EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGKLKE
MFPVIEQYGDILVKYLMQEAEKGKPVTMKD
VLGAYSIDVITSTSFGVNVDSLNNPEDPFVEKAKGILRVDFFDPLVFS
VVLFPFLTPVYEMLNICMFPKDSIEFFKKFVNRMKESRLDSKQK
HRVDFLQLMMNAHNNSKDKDSHK
ALSDMEITAQSIVFIFAGYETTSSTLSFTLYCLATHPDIQKKLQEEIDETLPNK
APPTYDTVMEMEYLDMVLNETLRLYPIGNRLERFCKKDVELNGVYIPKGSTVMIPSYALHHDPQHWPEPEEFQPER
FSKENKGSIDPYLYMPFGIGPRNCIGMRFAFMTMKLALTKVMQNFSFQPCQETQ
IPLKLSRQGLLQPEKPIVLKVVPRDVVITGA
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Cyp3a41-de1b2b mouse
GenEMBL NT_039318
exon 1,2 - strand
y in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
possible alternative exons for 3a41
1729618 MNLFSALSLDTLVLLAIILVLLYR 1729547
1727537 YGTCTHGLFKKQGIPGPKPLPFLGTVLNYYK 1727445
Note: These two exons are identical to 3A16 exons 1 and 2
This sequence is at the edge of the genome sequence gap between 3a41 and 3a44
The NT_039318 sequence has been removed in the new mouse genome assembly,
So these sequences could be due to errors in assembly.
Cyp3a41-de12c mouse
GenEMBL NT_039318 - strand
detritus exon 12
x in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1739825 SNGPRN*IGMRFALLNMKLTLTKVLQNFNFQPCKEIQ 1739715
note this seq is nearly identical to Cyp3a16-de12b
it is in a region of some uncertainty, and may be due to errors in assembly.
CYP3A42 Python regius (ball python or royal python, African snake)
GenEMBL AF319041
Mette Liljenberg, Tove Hegelund-Myrback and Malin Celander
Submitted to nomenclature committee Oct 22, 1999
59% to mouse 3a
CYP3A43 human
GenEMBL AC011904 8902-46787 13 exons
Gene assembled from genomic sequence by Henry Strobel
and David Nelson on Dec 11, 1999
intron exon boundaries defined by comparison to rat 3A9
and human 3A sequences. GT AG pairs found for all introns
ESTs AA417369 zu08d03.s1 AA416822 zu08d03.r1 Soares testis
Opposite ends of same clone
67% identical to rat 3A9
Assembled gene * = intron exon boundary ** = EST support for this boundary
MDLIPNFAMETWVLVATSLVLLYI*
YGTHSHKLFKKLGIPGPTPLPFLGTILFYLR*
GLWNFDRECNEKYGEMWG*
LYEGQQPMLVIMDPDMIKTVLVKECYSVFTNQM*
PLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKE*
MVPIISQCGDMLVRSLRQEAENSKSINLKE*
DFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLI*
SLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK*
HRVDFFQQMIDSQNSKETKSHK*
ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVLPNK**
APVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE**
RFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQ**
IPLKLDNLPILQPEKPIVLKVHLRDGITSGP*
coding region 504 amino acids
exon 1 8902-8972
exon 2 17239-17332
exon 3 19906-19958
exon 4 24929-25028
exon 5 28274-28387
exon 6 28952-29040
exon 7 30332-30480
exon 8 36377-36504
exon 9 37619-37685
exon 10 40616-40776
exon 11 42399-42625
exon 12 44323-44485
exon 13 46692-46787
CYP3A43-de1b human = CYP3A137P (name conflict with carp)
GenEMBL NT_007933.10|Hs7_8090 + strand alternate exon 1
24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214
CYP3A43-de4c6c human = CYP3A52P
GenEMBL NT_007933.12|Hs7_8090
chromosome 7 genomic contig
Length = 64383103
Last exon of 3A43 in build 33 of human genome
24697113 IPLKLDNLPILQPEKPIVLKVHLRDGITSGP* 24697208
CYP3A43-de4c6c = s in Fig. 3A,
old names = 3A52P, 3A53P
Exon 4 pseudogene fragment
24701048 MIKTVLVKECYSVFPNWR 24701101
exon 6 pseudogene fragment
24703375 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 24703464
CYP3A43 Pan troglodytes (chimp)
XM_527830.2
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWNFDRECNEKYGEMWELYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRLPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPQNCIGMRFALT
NIKLGVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
CYP3A43 Macaca fasicularis (cynomolgus monkey)
DQ074796
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP3A43
96% to human CYP3A43 only 75% to 3A4, 3A5
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKVGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKATVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQIPLKLNNLPILQPEKPIVLKVHLRDGITSGP
CYP3A43 Macaca mulatta (rhesus monkey)
XM_001098213.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mmul3a43
96% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFMKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RREAENSKPTNLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLSISLFPFLTPVFEVLNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETSLHHSLSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDIVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIKALQNFSFEPCEETQLPLKLNNLPILQPENPIVLKVHLRDGITSGP
CYP3A43 Macaca mulatta (rhesus monkey)
NP_001121102
UCSC Browser chr3:47099079-47140713 (+) strand
CYP3A43-de1b Macaca mulatta (rhesus monkey)
UCSC Browser chr3: 47090970-47091041 (+) strand
Ortholog to human CYP3A43-de1b, 4 aa diffs
pseudogene exon 1 between 3A4 and 3A43 (+)
8 kb upstream of CYP3A43
47090970 MDLIPNFAMDMWVLPATRLVLLYL (2) 47091041
CYP3A43-de4c6c Macaca mulatta (rhesus monkey)
UCSC Browser chr3: 47144523-47146892 (+) strand
ortholog to the human pseuddogene, 1 amino acid difference
47144523 MIKTVLVKECFSVFPNWR 47144576
47146803 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 47146892
CYP3A43 Pongo pygmaeus (orangutan)
EF589793.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a43
98% to 3A43 human
MDLIPNFAMETWVLVATSLVLLYIYGTHSHKLFKKLGIPGPTPL
PFLGTILFYLRGLWKFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKECYSVF
TNRMPLGPMGFLKSALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSL
RQEAENSKSINLKDFFGAYAMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDP
FLLLISLFPFLTPVFEALNIGLFPKDVTRFLKNSIERMKESRLKDKQKHRVDFFQQMI
DSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEE
IDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVLIPKGL
AVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDPYRYIPFGAGPRNCIGMRFALT
NIKLAVIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRDGITSGP
Cyp3a44 mouse
GenEMBL AB039380
Tsutomu Sakuma
Submitted to nomenclature committee 2/29/2000
This sequence differs from 3a11, 3a13, 3a16, 3a25 and 3a41 (90%)
Cyp3a44 mouse
GenEMBL AC111090.20 genomic clone
This clone contains part of 3a25, Cyp3a25-de8b9b12b, 3a11,
A pseudogene between 3a11 and 3a44, and most of 3a44
178101 MNLFSALSLDTLVLLAIILVLLYR 178172
180134 YGTRTHGLFKKQGIPGPKPLPFLGTVLNYYT 180226
182562 GIWKFDMECYEKYGKTWG 182615
184471 LFDGQTPLLVITDPETIKNVLVKDCLSVFTNRR 184569
188874 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 188987
189067 MFPVIEQYGDILVKYLRQEAEKGMPVAMKD 189156
189424 VLGAYSMDVITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPLLFSV 189570
192147 VLFPLLTPVYEMLNICMFPNDSIEFFKKFVDRMQESRLDSNQK 192275
193171 HRVDFLQLMMNSHNNSKDKDSHK 193239
195368 AFSNMEITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNK 195529
204141 ATPTCDTVMEMEYLDMVLNETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPS 204308
204309 YALHHDPQHWPDPEEF 204356 (runs off end, last section from AB039380)
QPERFSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLA
VTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIVLKVVPRDAVITGA
Cyp3a44-de9b10b11b12b mouse
GenEMBL AC111090.20 genomic clone
This seq is between 3a11 and 3a44. It is 13kb from 3a44, 20kb from 3a11
The exon 12 part used to be called Cyp3a11-de12b
The exon 9 part is identical to w in Figure 3B Nelson et al.
Pharmacogenetics 14, 1-18 2004.
165130 HQVDFLHLMINAHDKTKDKETHK 165062
160280 ALSNMEITTQSIMFIFASYKPTSSTLSFALCSLVTHHAS*KKLQENDKTLTNK 160122
156349 VELESLDMVLNETLRLYPTADRLVKVYKKDVELNDAFILKWSLEIVSCYSLCHDPQNWPEHKEFCPE 156149
148858 RFSMENKGSIDPYG 148817
148815 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQV 148690
Note: there was a sequence gap between 3a44 and 3a41 in the mouse genome assembly
This has now been filled. The pseudogene Cyp3a44-de9b10b11b12b is between
3a44 and 3a11. It is 86% identical to Cyp3a58-ps between 3a16 and 3a41.
The three genes [3a16, 3a58-ps, 3a41] represent a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11].
Note: the following sequences (4 exons) lie between 3a41b and 3a44
Cyp3a41b-de12b
(-)15459 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQ 15298
3 aa diffs to Cyp3a-se5[12]
Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]
CYP3A45 Oncorhynchus mykiss (rainbow trout)
No accession number
Su-Jun Lee, Don R. Buhler
96% to 3A27 but different 3 prime and 5 prime ends
CYP3A46 Sus scrofa (miniature pig)
EF625347
Haitao Shang
Submitted to nomenclature committee May 23, 2007 (partial)
Complete sequence in Genbank 03-SEP-2008
92% to 3A39v1, 76% to human 3A4 and 3A5
formerly CYP3A88. Name changed to CYP3A46 after whole sequence known
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILGYRKGVDHFDKKCFQQYGKMWGFFDGRQPVLAITDPDMIKTVLVKECYSVF
TNRRSFGPRGAMRSAVSLAEDEEWKRIRTLLSPTFTSGKLKEMFPIISHYGDLLVSNL
RKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNVDSLNNPQDPFVENSRKLLKFSFFSP
FFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSIKRMKESRLKDTQKHRVDLLQLMI
NSQNSKEMDAHKGLSNEELVAQGVIFIFAGYETTSSSLSLLVYELATHPDVQQKLQEE
IDATFPNKAPPTYDGLAQMEYLDMVVNESLRIFPVTPRLERSCKKDVEIHGVFVPKGT
VMMVPIFALHRAPELWPEPEEFRPERFSKKNKDTINPYTYLPFGTGPRNCIGMRFALM
NMKLALVRVLQNFSFKPCRETQIPLKISSQGLIQPEKPIVLMVVPRDGTTSGA
CYP3A46 Sus scrofa (miniature pig)
3 aa diffs to CB479861.1 EST, probably the same seq.
F22946.1 extends seq toward N-term.
AJ959509.1 overlaps F22946 with 1 aa diff in 42
Be aware this may be a hybrid of two or more gene sequences.
BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
DB799225.1
92% to 3A39v1
Formerly CYP3A88. Name changed to CYP3A46
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*
CYP3A46v1 Sus scrofa (pig)
GenEMBL AB052266
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
13 diffs with 3A39v1, 9 diffs with 3A46v2 all in the last 43 aa
clone name 3Ac4
two amino acid differences with full length CYP3A46
CYP3A46v2x Sus scrofa (pig)
GenEMBL AB052267
Misaki Kojima
Submitted to nomenclature committee Oct. 27, 2000
9 diffs with 3A46v1 all in the last 43 aa, 20 diffs with 3A39v1
clone name 3Ac28
the last 61 amino acids are identical to CYP3A22v2
this sequence appears to be a hybrid of CYP3A46 and CYP3A22v2
CYP3A46v3 Sus scrofa (pig)
EF625354
Partial sequence with 1 amino acid diff to CYP3A46
CYP3A47X Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Renamed CYP3D1
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQ (1)
GCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3A48 Fugu rubripes (pufferfish)
No accession number
Scaffold 1124a
44660 MDLLLNFSIETWTLLTLVFTLIIV 44589 (2)
44089 YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR 43997 (0)
43888 GVHHFDEECYKKYGKVWG 43835 (2)
43728 LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR 43630 (0)
43549 DLGLNGPLRDAVSVAEDEQWKRIRGILSPSFTSGRLKE 43436 (0)
43350 MYTIMLQHSKNLLNFLHKKVEADEVIDVKD 43261 (2)
42808 VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV 42662 (1)
42612 VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK 42452 (0)
42378 SRVDFMQLMVNAQMQEGNEEGSSQK 42310 (1)
42109 GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK 41948 (0)
41869 VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEI 41747
41746 NGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER 41648 (2)
41162 FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD 41001 (0)
40889 IPMVLNTEGLVAPKNPIKLKLKPRAVSS* 40803
CYP3A48 Fugu rubripes (pufferfish)
UCSC browser chrUn:165976318-165979993 (+) strand
Two genes separated by a seq gap
89% to CYP3A49 fugu, 82% to CYP3A49 Tetraodon
MDLLLNFSIETWTLLTLIFTLIIV (2)
YGYAPYGFFKKVGIPGPKPWPFIGTFLNYRR (0)
GIHHFDEECYKKYGKVWG (2)
LYDGRQPLMCIMDTGMIKTVLVKECYSNFTNRR (0)
DLGVNGPLSDAVSVAEDEQWKRIRGILSPSFTSGRLKE (0)
MYTIMLQHSKNLLNFLNKKVEADEVIDVKD (2)
VFGPYSMDVVTSTAFSVDIDSINNPSDPFVANIKEMTQFSFLNPLVVLT (1)
VLFPFLVPIFKKMNVSTFPAHVIDFFFNFLRQIKSDRNKDKKK (0)
SRVDFMQLMVNAQMQEGNEEGSSQK (1)
GLTDNEILAQAMIFIFGGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK (0)
VRPNYDDLMQLEYLDMVVNESMRVFPILSRLERMTKTSVEINGFTIPKGTVVAIPVYVLQHDKAYWPEPEAFKPER (2)
FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVPCKETD (0)
IPMVLNTEGLVAPKNPIKLKLKPRAVSS*
Note: CYP3A48 is missing in the Tetraodon genome assembly but it is found in GenPept
CYP3A48 Tetraodon nigroviridis (freshwater puffer)
CAF91666 GenPept
85% to 3A48 full (probable ortholog), 87% to 3A49 C-term fragment,
MDLLPDFSIETWTLIVLVFTLITVYGYAPYGFFKNLGIHGPKPWPFIGTFLNYRKGVHHFDQECYKKYGKVWSLFDGRQPLM
CIMDTLMIKTILIKECYSNFTNRRDLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKEMYTIMLQHPQNLINLLQKKV
KADDVIDVKDVFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILVVLFPFTQTIFDKMDVSLFPGHVL
DFFYNFLRQIKSDRSKEKKKSRVDFMQLMVNAHMTEDNEKDSSLKGLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNP
DIQKKLQEEIDKTFPGKVRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPAL
WPEPEAFKPERFSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETEIPMVLGSEGFVTPKTPI
KLKLKPRTSS
CYP3A48 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrXII:12771920-12775348, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
gac2628
70% to 3A48 Fugu, 72% to tetraodon 3A48,
MGFLPELSIQTWTLIVFLVTLITVYGYAPYGFFKKLGIPGPRPLPFIGTFLEYRKGIHNFDTECYEKYGKVWGIYDGRVPIL
VTMDTAMIKSILVKECYSNFTNRRDFGLNGALRDAITVVEDEEWKRIRSILSPSFTSGRLKEMYSIMLQHSGNLIKSLHKKA
EAGEVVDVKDIFGPYSMDVVASTAFSVDIDSINNPSDPFVANIRKLVKFTFLTPLFLLLVLFPFLEPMLDKMNVTLFPAELL
DFFYSFLKTIKSDRSKNEHKNRVDIMQLMVDSQMSETTKEDPSAHKGLSDSEILSQAMIFIFAGYETSSGTLGFLAYNLATN
PDIQKTLQEEIDETFPNKARPTYDALMQMEYLDMVLNESMRLYPSGNRLDRVSKSSVEIEGVTIPKGTVVMIPVYTLHREPT
LWPEPDDFKPERFSKENKDSIDPYSYLPFGAGPRNCIGMRFALLMMKLSVVEILQNFSFVTCKETQIPLELSTDGFTTPKDS
INLKLEPRGAHC
CYP3A49 Fugu rubripes (pufferfish)
UCSC browser chrUn:165961462-165963240 (+) strand,
exons 1-6 followed by a gap
at 204-207K on scaffold 35 95% to 3A48
FS:S000035 Scaffold_35
SLC6A8 PCTK1 DDX20 KCND2 CYP3A50P CYP3A49 CYP3A48 CAPZA1 APEH WNT5A
CAAB01000035.1 has this sequence from 204598-207532 (-) strand
MDLLPNFSIETWTLIALVITLITV (2)
YGYAPYGFFKKVGISGPKPWPFIGTFLNYKK (0)
GVHHFDEECYKKYGKVWG (2)
LYDGRQPLMCIMDTGIIKTILVKECYSNFTNRR (0)
DLGLNGPLRDAVSVTEDEQWKRIRGILSPSFTSGRLKE (0)
MYTIMLQHSKNLLNFLHKKVEADEVIDVKD (2)
VFGPYSMDVVTSTAFSADIDSINHPSDPFVANIKKMVKFNFLNPLLIFV (1?)
VLFPFTQPIFDKVDFSFFPAHVIDFFYNFLRQIKSDRNKDKKK (0)
SRVDFMQLMVNAQMQEGNEEGSSQK (1)
GLTDNEILAQAMIFIFAGYETTSSSLGFLAYNLATNPKIQKKLQEEIDKTFPGK (0)
VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMTKTSVEINGLTIPKGTVVAIPVYALQRDPVLWPEPEAFKPER (2)
FSKENKDNVDPYAYLPFGAGPRNCIGNRFALVLMKLAIAEILQHYSFVTCPETD (0)
IPMVLGNEGFVTPKNPIKLKLKLRDVSN
CYP3A49 Tetraodon nigroviridis (freshwater puffer)
87% to fugu CYP3A49, 82% to adjacent CYP3Axx gene
SLC6A8 PCTK1 DDX20 CYP3A50P CYP3A49 APEH TLR9
MDLLPDFSIETWTLIVLVFTLITV (2)
YGYAPYGFFKNLGIHGPKPWPFIGTFLNYRK (0)
GVHHFDQECYKKYGKVWS (2)
LFDGRQPLMCIMDTLMIKTILIKECYSNFTNRR (0)
DLGLNGPLRDAVSITEDEQWKRIRSILCPSFTSGRLKE (0)
MYTIMLQHPQNLINLLQKKVKADDVIDVKD (2)
VFGPYSMDVVTSTAFSVDIDSINHPSDPFVANIKKMVKFNFMNPLLILV (1)
VLFPFTQTIFDKMDVSLFPGHVLDFFYNFLRQIKSDRSKEKKK (0)
SRVDFMQLMVNAHMTEDNEKDSSLK (1)
GLTDKEILAQAMIFIFAGYETTSSSLGFLAYSLATNPDIQKKLQEEIDKTFPGK (0)
VRPNYDDLMQLEYLDMVVNESMRLYPIANRLERMAKTSVEINGVTIPKGTVVAIPVYALHRDPALWPEPEAFKPER (2)
FSKENSANIDPYTYLPFGAGPRNCIGMRFALVVMKLAIAEILQHYSFVPCKETE (0)
IPMVLGSEGFVTPKTPIKLKLKPRTSS*
CYP3A50 Fugu rubripes (pufferfish)
chrUn:165954227-165957711 (+) strand
at 212-211K on scaffold 35
the improved version of this seq does not look like a pseudogene
MNFLPDFFLNTWTFLILVIVLSTT (2)
IKRVGIRGPTPWAPLIGDIFYSTRRG (1)
KCCKRYGKVWG (2)
LYEGRIPVMFIVDTAMIKTVFVKEGYSVFLNRK (0)
SIGPNGILSTGLPFLRDDNWKRVHKIVSPAFSSGRMKD (0)
MFSIMLQHSNILM
FSIDIESLNNPSSPFLHYLQEVSKYNYMNLWRLLG (1)
AIFPFLTPLMDKMNITVNSSEALQFFISVIKKIKEERKNNPK (0)
DRVDFMQLMLNAQAPDGSNKDCDSA (1)
GLSDEEIMVQALIFALVGNGNMAYLVAFTAYNLAVHPQTQTRLQAEIDRTFPGKVSPN (1)
SYEELLQLKYLDMVVTETSRLYPLGNRIERVAKSTVEVSG
VIIPEGVAVAVPIYTLHRDPTVWPDPDSFKPER (2)
FSKDNRDNIDPYGLL
GPRSCTGTRMSMLVVKLTLVEILQHFSFVACKETM (0)
IPMVLDDNGFVHPKTPIMLIPARTPGSCFSACTYVINVLLTVRRLICSLIN*
CYP3A50P Tetraodon nigroviridis (freshwater puffer)
ortholog of fugu CYP3A50P pseudogene upstream of CYP3A49
58% to CYP3A49 Tetraodon, 69% to CYP3A50P fugu
MGFFPDLCTETWTLLALVFVL
YTLFKRLGIKGPMPWPFIG
VGNNNMATSVAFAAYNLALHPEVQKKLRAEIDRTFSGK (0)
CRPTYEKLVQMKYLEMVIKETLRLYPIGNRIERVAKSNVEVSGVIIPKGMVVATPIHTLQRDPDVWPDPDSFKPER (2)
FNNDSIDPYGFLTFGTGPRACIGMRLSILIMKLALVEILQHFSFASCKETD (0)
IPLELARNGFVLPKKPIML &
KLEPREPAA*
CYP3A51P human = CYP3A5-de13c
GenEMBL NT_033964.1|Hs7_34119
chromosome 7 detritus exon 13 upstream of 3A5
old name = 3A51P, note: this name is being used by the HGNC
254208 IPLKLRLGGLLQPEKPIVLKVESRDGTVSG 254297 ex13
because the HGNC has strict rules for gene names,
The old names (CYP3A51P, etc.) are being used by the HGNC
These will be synonyms.
CYP3A52P human = CYP3A43-de4c6c
AC011904 part of exon 4 downstream of CYP3A43, 88% to 3A4
MIKTVLVKECYSVFPNWR
67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6
CYP3A53PX human merged with CYP3A52P
NT_033964.1|Hs7_34119 Homo sapiens chromosome 7
detritus exon 6 downstream of 3A43
new name = CYP3A43-de4c6c
67275 EMLLIIL*YGDVFLRNLRQKVEKGKPLTLR 67186 ex 6
CYP3A54P human = 3A-se1[2]
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A55P human = 3A-se2[5]
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
CYP3A56 Fundulus heteroclitus (killifish)
AY143428
Tove Hegelund and Malin Celander
64% to 3A48 Fugu 99% to 3A30
submitted to nomenclature committee 6/20/02
MGYFYLTAETWTLLVAFVTLLLIYAYWPYGTFKRLGISGPKPVP
FFGTMLHYRRGFFTFDEECKKKYGKVWGIYDGRQPVLCVTDPEIIKAVLVKECLSFFT
NRRNFHLNGPLYDALSVAEDDQWKRIRSVLSPSFTSGRLKEMFEIMKNHSANLIRSMK
KKADKDEPLDLKEFFGSYSMDVVTSTAFSVDIDSLNNPSDPFVTNIKKMLKFDFLNPL
FLAVAFFPFLGPILEKFELSFFPKSVTDFFYASLEKIKSNREASQQKSRVDFLQLMID
SQKNSGAQQDKSLTDHEILSQSMIFIFAGYETSSSSLTFLAYNLATNPEVMKKLQEEI
DATFPNKAPVHYQPLMEMEYLDCVINESLRLFPIAARLERVAKAAVEINGIVIPKDMV
VMIPTWPLHRDPEIWPEPEAFKPERFSKKNKDNIDPYIYMPFGSGPRNCIGMRFALVL
IKLAVVEILQQYSFSVCKETEVPFEMDIQGLLAPKRPIQLKLVPRS
Cyp3a57 mouse
GenEMBl AC115895.3, XM_144630 XP_144630 Genbank assembly incorrect
AC115895.4 13 exons, exon 9 is backwards
NT_039318
MELIPNLSIQTWVLLVTSLVFFYI
YGTYSHGLFKKLGIPGPKPLPLFGNIINYLD
GMWKFDDDCYKKYGKIWG
FYEGPQPILAIMDPEIIKIVLVKECYSVFTNRR
PFGPVGFLKKSITISEDEEWKRLRTLLSPTFTSSKLKE
MFPIMRQYGDILVRNLRREEEKEEPINMK
DIFGAYSMDVITGTSCGVNIDSLNNPQDPFVQKIKKILKFKFFDPFLLS
VVLFPFLTPIYEMLNLSIFPRQSMNFFKKFVKKMKKDRLDYNQK
NRVDFLQLMMNTQNSKGQESLK
ALSDLEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRALPNK
APVTYDALMDMEYLDMVVNESLRLYPVVSRIDRFSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPER
FSKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQ
IPVKISRQPIFRPEKPIILKFVSRDKPRTGP
Cyp3a58-ps mouse
GenEMBL NT_039318 + strand
Between 3a16 and 3a41
Note this seq is 86% identical to Cyp3a44-de9b10b11b12b
[3a16, 3a58-ps, 3a41] is probably a tandem duplication of
[3a44, 3a44-de9b10b11b12b, 3a11]
exon 8
1629527 PVFFSFLNPI*EMLKISVFPKDSIAFFKKKLWTEQRKTSWILSKR 1629661
exon 9 new fron UCSC Browser
26701 HQVDFLHLMINAHDNTKDNESHK 26769
exon 10
1651425 ALSNIEITTQSIMFIFASYEPTSSTLSFVLYLLVTHHDIWKKLQENDRALPNK 1651583
exon 11
1660734 VEMEYLDMVLNETLRLYPTADRFVKVYKKDVELNDAFILKWS 1660859
exon 12
1669382 FSMENKGSIDPYX 1669417
1669422 YMPFGNGPRNCISMRFAVMSMKFALTKVLQNCYLHPCKETQ 1669544
Cyp3a59 mouse
GenEMBL NW_000248.1|Mm5_WIFeb01_96 gene interrupted by gaps
AC113316.2
old temp name = cyp3agg
93% to Cyp3a25
LLLYRYGTYSHGLFKKLGIPGPKPLPLFGTIFNYFD
GMWKFDEDCYKKYGKIWG
FYVGPKPILAIMDPEIIKIVLVKECYSVFTNR
RLLGPVGFLKKSITISEDEEWKRLRTLLSPTFTSGKLKE
MFPIMRQYGDILVRNLRREEEKGEPINMKE
IFGAYSMDVITGTSFGVNIDSLNNPQNPFVQKTKKILKFKIFDPFLLS
VVLFPFLTPIYEMLNLSIFPRDSMNFFKKFVKRMKKERLASKQK
NRVDFLQLMMNTQNSKGQESQK
ALSDLEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNK
APVTYDALMDMEYLDMVVNESLRLYPTAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLH
RNPEYWPEPQEFCPG
RFSKENEGNIDPYIYMPFGNGPRNCLDMRFALISMKLAVIGVLQNFTVQPCEETQ
IPLKISREPVFQPEKPIILKVVSRDKPRT
Cyp3a59-de11b mouse
GenEMBL NT_039324.1 - strand
detritus exon 11
p in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
191646 VSFLLVTLVEIEYLDILVT*ILRLNPIGNRLESVSKK 191536
191539 EMFEVFIPKGTRVTVLTFALH*DEQYWPEXXXXXXXX 191453
Cyp3a60-ps mouse
GenEMBL NT_039324.1 + strand
Cyp3a ps about 60% to 3A25
exon 2
331420 PVRLPVIGLLLSLYN 331464
exon 5
338061 KKVITISEEDERKRL*TLLSPTFIS 338135
exon 6
338410 MFPIIGQYGETLVK 338451
338451 KKRKGEPINMKE 338486
exon 7
338734 SMDVVTGTLFGVNVDSLTNSSDPCAESQGDLNKFEFS*PTSLG 338862
exon 8
341951 VAMLPFLTTIYKILSISIFP 342010
342409 KYMKQSRLDTNQK 342447
Cyp3a61-ps mouse
GenEMBL NT_039315.1, also on NW_000239.1
Old temp name = Cyp3ayyp
Exons 10,11,12,13
1115767 ALSDLEIVAQSISFIFAGYETTSNTLSYIMYTLATHPDVQKKLQQEIDAILPNK 1115606
1113252 APATYNDLEKIEYLDMVINETLRLYPIGARISRLSKKDAEINGVFIPQNTEVAVPVF 1113082
1109396 FSQENKDRINPYVYMPFGNGPRNCLGMRFALINMKLAVVKILQNFSVQPCEDTE (0) 1109235
1108058 IPLKLSKKLILSPEKPIVLKVTARDGAINEG* 7963
Cyp3a61-de11b mouse
GenEMBL NT_039315.1, also on NW_000239.1
Old temp name = Cyp3azzp
detritus exon 11 next to Cyp3a61-ps
n in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
1136553 APATYNGLVKIRYLDMVINETLRLYPVGVRISRLSKKDAEINGVLTPQNTK
VDVALFVLH*DPEYWPXXXXXXXXX 1136353
CYP3A62 rat
GenEMBL AB084894
Matsubara T, Kim H. J, Miyata M, Shimada M, Nagata K and Yamazoe Y.
Isolation and characterization of a novel rat CYP3A, CYP3AL1,
predominantly expressed in intestinal tract Unpublished 2003
80% to CYP3A9, 78% to Cyp3a13
MDLIPNISLETWMLLATILVLLYLYGTSTHGNFKKLGISGPKPL
PFVGNILAYRHGFWEFDRHCHKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTF
TNRRSFGPAGILKKAITLSEDEEWKRLRTLLSPTFTSGKLKEMFPIINQYADLLVKNV
KHEAEKGNPITMKDIFGAYSMDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFNFLDP
FFLSVILFPFLTPVFEAFDITVFPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMI
NSQSSGDKESHQGLTDVEIVAQSIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDE
IDAALPNKAPVTYDVLVEMEYLDMVLNETLRLFPVGGRLERVCKKDVEINGVFIPKGT
VVMVPTFALHKDPKCWPEPEEFCPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALM
NMKIALVRVLQNFSFGLCKETQIPLKLRKKGFFQPEKPIILRAVSRD
Cyp3a62-de11b rat
GenEMBL NW_001084671.1 11932479-11932637
11932637 KKNQDSISPYVYLPFGFRPRNCIGMRFALMNMKVALVRVLQNFSFQPCKEIQL 11932479
Cyp3a63-ps mouse
The following seqs are part of one pseudogene 3a63-ps
GenEMBL NT_045749.1|MmUn_45789_30
3a exon 2 same as 3a63-ps
396 YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK 304
NT_071156.1|MmUn_71196_30
exons 5,6,7 same as 3a63-ps
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
old name = Cyp3a44-se3[10] NW_037585.1|MmUn_WIFeb01_5425
3 diffs to 3a44
same as CYP3A63-ps
649 AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
old temp name = Cyp3attp
80% to 3a11 NW_008810.1|MmUn_WIFeb01_17679
one frameshift and small deletion same as CYP3a63-ps exon 11
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPS
YALHHHWPESEEFQPER
Old name = CYP3A44-se1[12] NW_005077.1|MmUn_WIFeb01_14285
2 diffs with CYP3a44
1231 RFSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ 1067
Cyp3a63-ps AC114427.2
This sequence is between 3a41a and 3a41b
Note: Cyp3a44-de12c has only one aa diff to this seq
63090 MNLFSALSLDTWILLAIILVLLYR 63019 probable beginning of pseudogene
YGTLTQGLFKKQGIPGPKALTFLGTVLNYYK
GFWKFDMECYEKYGKTWG
LFDGQMPLFVITDP*MIKNVLVKECFSVFTNRR
868 EFGPVGIMSKAISISKDEEWKRYRALLSPTFTSGRLKE 755
675 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 586
316 VLGAYIMDVITSTSFGVNVNSLNNPEDSFVEKARKILRVDFFDPLLFS 162
HRVDFLQLMMNAHNNSKDKDSHK
AFSNMEITAQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQEEIEKALPNK
VPPTYDSVMEMEYLDVVLNETLRFYPIVTRLERVCKKDVELNGVYTPKGSTVMIPSYALHH(fs)HWPESEEFQPER
FSKENKGSIDPYVYMPFGIGPRNCIGMRFALMNMKLALTKVLQNFSFQPCQETQ
IPLKLSRQGILQPEKPIVLKVVPRDAVITGA
The following sequences are bewtween 3a41a and 3a63-ps
(-)11231 FSKESKGNIDPYIYLPFGNGPRN*IGMSFALLNMKLTLTKVLQNFTFQPCKETQV 11067
two sites have exact matches 145849323- 145849487 between 3a41a and 3a63-ps and
146039664- 146039828 between 3a41b and 3a44
3 aa diffs (94%) to Cyp3a-se5[12] probably a poor quality seq match
Cyp3a-se12[8:9:10]
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
IVERTKENCLDSKQK
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10]
(+)31398 SPVQMEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10
The following sequences are bewtween 3a63-ps and 3a41b
Cyp3a-se13[9]
76087 HQVDFLHLMINAHDKTKDKETHK
identical to exon 9 of Cyp3a44-de9b10b11b12b includes old frag w from map
128725 RFSMENKGSIDPY 128763
128769 GPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQV 128876 = Cyp3a-se10[12]
CYP3A64X Macaca mulatta (rhesus monkey)
Analysis of the genomic DNA shows this gene is syntenic with
human CYP3A4 so it has been renamed CYP3A4
No accession number
Tom Rushmore, Merck & Co. Inc.
Submitted to nomenclature committee 6/30/2003
92% to CYP3A4
CYP3A65 Danio rerio (zebrafish)
No accession number
Hua-Bin Tseng, Hou-Chu Yin, Chin-Hwa Hu,
Jun-Lan Wang-Buhler, and Donald R. Buhler
Submitted to nomenclature committee 10/10/2003
71% to 3A27 trout, 71% to 3A45 trout, 69% to 3A40 Oryzias,
69% to 3A30 Fundulus, 69% to 3A56 fundulus,
56% to 3A37 chicken, 58% to 3A48 fugu 59% to 3A49 fugu, 45% to 3B2
CYP3A66X Macaca mulatta (rhesus monkey)
No accession number
Brian A. Carr, Merck & Co. Inc.
Submitted to nomenclature committee 4/22/2004
91% to CYP3A5, 83% to CYP3A4, probable ortholog of CYP3A5
name has been changed to indicate orthology = CYP3A5
CYP3A67 Pan troglodytes (chimpanzee)
EF507836
Eric Williams, Henry Strobel
Recent gene duplication of CYP3A7
CYP3A67 Pan troglodytes (chimpanzee)
NM_001093774
MDLIPNLAVETWLLLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFVGNVWSFRKGFWTFDMECYKKYRKVWGFYDGLQPVLAITDPDMIKTVLVKECYSVF
TNRRPLGPVGFMKSAISRAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNL
RREADTGMPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNSLDP
FILSIKIFPFLTPILEALNITVFPRKVTSFLTKSVKRIKEGRLKETQKHRVDFLQLMI
DSQNSKDMESHKALSDLELVAQSIVFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKFALVRVLQNFSFKPCKETQIPLKLRFGGLLRTEKPIVLMAESRDETVSGA
CYP3A67 Pongo pygmaeus (orangutan)
EF589796.1
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ppy3a67
96% to 3A67 chimp
MDLIPNLAVETWLLLAVSLILLYLYGTHSHGLFKKLGIPGPTPL
PFVGNALSFHKGFWTFDMECYKKYRKVWGFYDGLQPVLAITDPDMIKTVLVKECYSVF
TNRRPLGPVGFMKSAISRAEDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYADVLVRNL
RREAETGKPVTLKDFFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNSLDP
LTLSIKIFPFLIPILEALNVTVFPREVTSFLTKSVKRIKEGRLKETQKHRVDFLQLMI
DSQNLKDTESHKALSDLELVAQSIVFIFAGYETTSSVLSFIIYELATHPDVQQKLQEE
IDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGV
VVMIPSYVLHHDPKYWIEPEKFLPERFSKKNKDNIDPYIYTPFGNGPRNCIGMRFALM
NMKFALVRVLQNFSFKPCKETQIPLKLRFGGLLRTEKPIVLMAESRDETVSGA
CYP3A68 Large mouth bass
DQ786406
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-a
74% to CYP3A27 trout
MGYFFFFSAETWTLLVALITLIFVYVCWPFGTFKKMGVPGPRPI
PFFGTMLAYKKGFMHFDSECFKKYGKTWGIFDGRQPVLCITDPAMIKTVLIKECYSLF
TNRRNFRLNGELYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLISSM
KKTADKDEPLELKEFFGPYGMDVVTSTAFSVDIDSLNNPTDPFVANIKKMLKFDLFNP
IFLFIAFFPFMAPILEKLEFSFFPKSVLDFFYAALKKIKANRETTKLKNRVDFLQLMI
NSQKNNDLSKVENDKGLNDHEILSQAMIFLFAGYETTSSSLTFLAYNLARNPHVMKRL
QEEVDATFPNKAPVEYQALMQMEYLDSVVNESLRLYPIAPRLERVAKATVEINGLVIP
KGMVVMVPTWPLHRDPDLWPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRF
ALVLMKLAVVEILQTYSFSVCKETEIPIELDIQGLISPKRPIKLKLVPRSEPSN
CYP3A69X Large mouth bass
DQ786407
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-b
64% to CYP3A47 Fugu
note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR
CYP3A70 Macropus giganteus (Eastern grey kangaroo)
DQ888646
Ross McKinnon
Submitted to nomenclature committee Oct. 25, 2004
65% to CYP3A4
NOTE: THIS SEQ IS MOST LIKE RAT 3A9 compared to other rat 3As
Therefore the 3A9 seq may be the oldest of the cluster in rats
3A9 is orthologous to 3a13 in mouse. Both sequences are on the
outside edge of the cluster.
MNIIPSLSAGTWALLVLFLTLLFLYGTWTHKLFKDLGIPGPAPL
PFFGTVLSYRKGFTDFDMTCFKKYGKTWGFFDGRKPVLSIMDPETIKLVLVKECFSVF
TNRRSFGPAGIMESAISIAEDDQWKRIRTILSPTFTSGKLKEMFPIIKQYGDVLVKNM
GKEAEKSKPVSLKDIFGAYSMDVITSTSFGVKTDSLNNQDDPFVREIRKLIKFNFLDP
LLLTVSIFPFVIPLLKKMDVTIFPKETLDFLTKSIKKIKEDRKKNSQKNRVDFLQLMM
DSQTSKNSEMHSQKDLSDDEILAQSVIFIFAGYETTSSVLCFLFYHLATHPEIQQKLQ
GEIDAVLPNKEAVTYDALVQMEYLDMVIHEILRLYPIAGRIERVAKKTVEINGVKIPK
GTVVMVSPFVLHRDPDYWPEPEEFRPERFSKENRESMNPYVYLPFGAGPRNCIGRRFA
LMSMKVATSLVLQEFSFRTCKETQIPVKLNNQPLISPTIPIVLQAVPRSKKGNQH
CYP3A71P rat
UCSC Browser chromosome 12
pseudogene 78% to 3A2
9497641 LFEWHTPVFAITDREMIKNVLVKECFSVFTNWR 9497543 exon 4
9468424 DLGPMGIMNKSIAF*KDEEWKRYRALLSPMFTSGKLKV 9468311
9468234 MFPIIKLYGDILVKYLRQEAEKGKPVSVKE 9468145
9467886 IFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKFLRLDYFDPLFISV 9467737
9464756 GLFPFLKPIYDMLNISVFPKDSIAFFKNFVYSMKESHLDSKQK 9464631
9453844 YQVDFFQLMMNAHNNSSESHK 9453782
9451670 FPALSDIEIIAQSIIFTFGGYDTTSSTLSFVLYSLATHSDVQKKLQEEIDHALPNK 9451503
9449744 ASPTYDIVMEMEYLDMVFNETLRLYPVTGRLHRMCKKDIELDGVFIPKG
SMVMIPLYPLQHDPQHWPEPEEFRPE 9449520
9447351 RFSKENKCRTGHYVYLPFGNGPRNCLGMRFALMSMKLAVTKVLQNFSFHPCKET 9447190
9444444 QIPLKLSKQVILKPEKPIVLKVVPRDGVING 9444352
CYP3A72 Balaenoptera acutorostrata (Minke whale)
AB290009
Iwata Hisato
submitted to nomenclature committee 1/6/05
83% to CYP3A28 cow, 78% to 3A5 human, 75% to 3A5,
74% to 3A4, 71% to 3A43
MDLIPSFSVETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPL
PYFGNILSYRKGLWEFDNRCFKKYGKMWGCYEGQQPLLVITDPDIIKTVLVKECYSVF
TNRRAFGPVGIMKNAISLSEDEQWKRIRTLLSPAFTSGKLKEMFPIISQIGDVLVRNL
KKEAEKGKPISMKDFFGAYSMDVITGIAFGVNIDSLNNPQDPFVEYSKKILKFNLLSP
LLLSIVLFPFLTPVFEALNITLFPKSSLNFLTKSVKRIKESRLKDKQTHRVDFLQLMI
NSQNSKETDTHKVLSDTELMAQSIIFIFAGYETTSNSLSFIIYELATHPDVQQKLQEE
IDATFPNKAPPTYEALVQMEYLDMVLNETLRIFPIAGRLERVCKKDVEVNGVFIPKGT
TVVVPLFVLHNDPELWPEPQEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFVIM
NMKLALVRILQNFSFKPCKETQIPLKLLTQGLTQVEKPVVLKVVSRDATISGA
CYP3A73 rat
chr12_random_1.5 (from UCSC browser)
80% to 3A44 81% to 3A41 80% to 3A16 83% to 3A11
86% to 3A2 rat
this gene lies between Cyp3a85-ps and Cyp3a18
MDLVSALSLETWLLLAIILVLFYR (2)
FGTRTHGIFKKQGIPGPKPLPFLGTVLNYYR (0)
GLWKFDMECYKKCGKIWG (2)
LFDGQTPVFAIMDTEMIKSVLVKECFSVFTNRR (0)
NIGPVGIMSKSISVAKDEEWKRYRAFLSPTFTSGRLKE (0)
MFPIIEHYGDILVKYLKQKVEKGKPLAMKE (2)
VFGAYSMDVITSTSFEVNINSINNPKDPFVEKVKKFQRFDFFDPLFLSV (1)
VLFPFLTPIYEMLNICLFPKDSVAFFQKFVYRMKQTRLDSKHK (0)
HRVDFLQLMMNAHNNSKDKVSHK (1)
ALSDIEIVAQAIIFIFASYETTSSTLSFVLYSLATHPDSQKKLQEEIDRALPNK (0)
APPTYDTVMEMEYLDMVLNETPRLYPIGYRLERVCKKDIKLDGVFIPKGSVVMIPFYTLQHDPQHWPEPEEFLPER (2)
FSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQLCEETQ (0)
IPLKLSRQRLFGPEKPIVLKVVPRDAVITGA*
CYP3A74 Bos taurus (cow)
See cattle page for details
MELILSFSTETWVLLATGLVLLYL (2)
YGTYSYGLFKKLGVPGPRPLPYFGNILSYRK (0)
GVCEFNEECFKKYGKIWG (2)
IFEGKQPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPSGVMKNAISVAEDEQWKRIRTLLSPTFTSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDIKD (2)
IFGAYSMDVITSTSFGVNIDSLGNPQDPFVENVKKLLRFSILDPFLLAV(1)
VLFPFLVPILDVLNITIFPKSAVNFFTKSVKRIKESRLKDNQK(0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPEPEEFRPER (2)
FSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0)
IPLKISSQGVLRPEKPVVLKVVLRDGTISGA*
CYP3A75 Bos taurus (cow)
See cattle page for details
MELIPSFSMETWVLLSISLVLLYL
YGTYSHGLFKKLGVPGPRPLPYFGNVLSYRK
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSV
VLFPFLVPIFEVLNITMFPKSAVNFLAKSVKRIKESRLKDNQK
PRVDFLQLMINSQNSKETDNHK
ALSDQELMAQSVIFIFAGYETTSNTLSFLLYILATHPDVQQKLQEEIDVTFPNK
APPTYDVLAQMEYLDMVVNETLRMFPITVRLDRLCKKDVKIHGVSIPKGTTVTVPISVLHRDPQLWPEPEEFRPER
FSKKNKDTISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKSCKETQ
IPLKINSQGLIRPEKPIFLKVVLRDETISGA*
CYP3A76 Bos taurus (cow)
See cattle page for details
MELIPNFSVETWVLLAISLVLLYL(2)
YGTYSHGLFKKLGVPGPRPLPLFGNVLSYRK (0)
GVCEFDEECFKKYGKMWG (2)
IFEGKHPLLVITDPDMIKTVLVKECYSVFTNRR (0)
VFGPMGVMKNAVSVAEDEQWKRIRTLLSPTITSGKLKE (0)
MFPIIGKYGDVLVRNLRKEAEKGTSVDMKE (2)
VFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILDPFLLSV (1)
VLFPFLIPIFEVLNISIFPKSAVNFLTTSVKKIKESRLKDTQK (0)
PRVDFLQLMINSQNSKETDNHK (1)
ALSDQELMAQSIIFIFGGYETTSTSLSFIIYELATHPDVQQKLQEEIDATFPNK (0)
APPTYDVLAQMEYLDMVVNETLRMFPIAVRLERFCKKDVEIHGVSIPKGTTVTVPISVLHRDPQLWPELEEFRLER (2)
FSKKNKDSISPYVYLPFGTGPRNCIGMRFAIMNMKLAVVRVLQNFSFKPCKETQ (0)
IPLKIKSQGLLRPEKPIFLKVVLRDETISGA*
CYP3A76-ie6b Bos taurus (cow)
See cattle page for details
extra exon 6 SCAFFOLD300381 other exon 6 at 7654
9898 MFPIIGKYGDVLVRNLRKEAEKGKSVNMKE
CYP3A77 Alligator mississippiensis (alligator)
GenEMBL AB186129
Satomi Kohno
Submitted to nomenclature committee Aug. 18, 2005
54% to 3A48 Fugu, 57% to 3A27 trout, 61% to 3A5 human
62% to ball python CYP3A42
clone name CYP3A_AA
CYP3A78 Phascolarctos cinereus (koala, marsupial)
No accession number
Ross McKinnon
Submitted to nomenclature committee July 29, 2005
56% TO 3A4 AND 3A5, 77% TO OPOSSUM 3A (UNNAMED)
CYP3A79 Mediterranean sea bass
GenEMBL DQ268535 not yet available on Jan 4, 2006
Pier Giovanni Gervasi
Submitted to nomenclature committee Dec. 14, 2005
CYP3A80 Gallus gallus (chicken)
GenEMBL XM_414782
Note: chicken has two CYP3As about 25kb apart on chr 14
See CYP3A37
MGLLPDLPPITWLLLAAFLGLLVLYGIWPYQTFKKLGIPGPRPL
PFLGTFLRYRQGLLNFDQMCFEKYGKIWGIYDGRQPVMAILDPVLIKTILVKECYSTF
TNRRVFGLSGRLESALSMAMDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGDKLVKNI
EKKVANEEFLDIKSIFGAYSMDVVASTSFSVDIDSMSKPSDPFVTNIRKFLKFSFLNP
LLIFIVLFPFMIPVLEKMNVTLLPTKVMDFFDAVFMKMKKEREEGYHVDRVDFLQLMI
DSQSSQDSSKSAREKDSYKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKRLQDEIDANLPNKAAPTYNVVMQMEYLDMVVNESLRLHPPGGRIERICKKTVEFNG
VTIPKDMVVMIPAYVLHRDPAYWPKPEEFRPERFSKENGENIDPYTFLPFGAGPRNCI
GMRFALLIVKVAMVVLLQNFSFKPCKDTPIPLVLDTKGFMQPKKPIILKMVPRAHSDP
QN
CYP3A80 Meleagris gallopavo (turkey)
DQ450082
Shirley Yip, Roger Coulombe, Jr.
Submitted to nomenclature committee Jan. 20, 2006
Clone name CYP3A-F2
90% to chicken 3A80 probable ortholog
MGFLPDLSPITWLLLVAFLSLLVLYGIWPYQTFKKLGIPGPQPV
PFLGTFLGYQQGILNFDQMCFEKYGKIWGIFDGRQPIMAILDPALIKTILVKECYSTF
TNRRVFGLSGRLESAVSMAVDDQWKRIRTVLSPTFTSGKLKEMFPIIESYGEKLVKNI
EKKVANEELLDMKNIFGAYSMDVVASTSFSVDVDSMSKPSDPFVTNIRKFLKFSFLNP
LLMFIVLFPFMIPVLEKMNVTLLSNEVMDFFDVFFMKMKKEREKGYHMNRVDFLQLMI
DSQSSQDGSKTAEEKDSHKSLSDEEILAQALIFVFAGYETTSSTLSYISYHLAIHPDV
QKQLQDEIDANLPNKAAPTYNAVMQMEYLDMVVNESLRLYPAGGRIDRVCKKTVEFNG
VTIPKDMVVMIPIYVLHHDPEYWPKPEEFRPERFSKENRENIDPYTYLPFGAGPRNCI
GMRFALLVVKVAVVALLQNFSFRPCKDTPIPLVLDTKGFMQPKKPIVLKMIPRAHGDL
QN
CYP3A80 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80049345-80104701
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
mdo1
63% to CYP3A80 chicken (ortholog)
MTSYSGLSTETWTLLVAFVTLLILYGIWPYGIFKKLGIPGPRPLPFFGTFLEYRKGILEFDKQCFQKYGKMWGFYDGRLPIL
AILDPDIIKIVLVKEFYTLFTNRRNFGLNGILDSGITVAEGEKWKRIRSIISPTFTTGKLKEMFPIIKHHIDVLVNNIEKKV
AQDESVNMKDIFGAYSLDVITSTSFGVDIDSINKPNDPLLVHIKKLLSFSFMSPLLILILVFPSLVPILEKMNLSLLSKENI
DFLVNASRRIIADRKKSNSRDRVDFLQLMIDSQVMNGSRSEKRNNSPKALTEMEIVAQAVTFIFAGYETTSTTLNFITYNLA
THPEIQKKLLEEIDSTLPNKAVPTYDTIFQMEYLDMVVNETLRLFPLGGRIERICQKTAEINGITIPKGTVMLIPVYVLHHD
PEYWPEPEEFRPERFDQEGRKSIDPYVFLPFGAGPRNCVGMRFALLTLKTALVTLLQNFTMEPCKETPIPLELETKGFMQPK
KPIILKLVPRPRPDVED
CYP3A81 Xenopus tropicalis (Western clawed frog)
See Xenopus pages for seq
UCSC Browser scaffold_76:65898-87839 Aug. 2005 (xenTro2) assembly
NM_001015786.1 59% to 3A5 from refseq database
94% to CYP3A81a, 92% to CYP3A82v1, 91% to 3A82, 88% to CYP3A81b
MNLIPHLSTGTWILLAALLVLILLYGIWPYGYFKKMGIPGPTPL
PFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVLAIMDPAIIKTILVKECYTNF
TNRRNFGLNGPFESAITIAEDEQWKRIRNVLSPTFTSGKLKEMFQIMKDYSDILVKNI
QGYVEKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLKTGLLSP
LLILVVIFPFLRPILEGLNLNFVPKDFTEFFMNAVTSFREKRKKGDHSGRVDLLQLMM
DSRTTGGNDLSNKHKALTDAEIMAQSVIFIVAGYETTSTALSYLFYNLATHPDVQQRL
HEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSKQNVEINGVSIP
KGIVTLIPAYVLQRDPEYWPEPEEFRPERFSKENRATHTPFTFLPFGDGPRNCIGLRF
ALLSMKVAIVTLLQNFSVRPCAETLIPMEFSTIGFLQPKKPIVLKFLSRAAAHE
CYP3A81a Xenopus laevis
AAI29607.1 GenPept
94% to CYP3A81 (possible ortholog),
90% to CYP3A81b, 90% to CYP3A82v1, 89% to 3A82
formerly CYP3A125
renamed CYP3A81a, presumed ohnolog to CYP3A81b (90%)
CYP3A81a and CYP3A81b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE
CYP3A81b Xenopus laevis
AAH60496.1 GenPept
90% to CYP3A82v1, 90% to CYP3A81a, 89% to 3A82, 88% to CYP3A81
formerly CYP3A123
renamed CYP3A81b, presumed ohnolog to CYP3A81a (90%)
CYP3A81a and CYP3A81b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE
CYP3A82v1 Xenopus tropicalis (Western clawed frog)
UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
98% to 3A82 (different scaffold, but possible allele)
92% to 3A81, 90% to CYP3A81b, 90% to CYP3A81a
renamed CYP3A82v1, adjacent to CYP3A81
formerly CYP3A122
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE
CYP3A82v2 Xenopus tropicalis (Western clawed frog)
UCSC Browser scaffold_1918:6381-20049 Aug. 2005 (xenTro2) assembly
BX779027 CX415432.1 93% to 3A81 N. Abdletawab
CX415433 = mate pair
Trace archive 243619963 419527443 418746304
476067541 (exon 1)
416306382 joint before I-helix
98% to 3A82v1 (different scaffold, possible allele),
91% to 3A81,
89% to CYP3A81b, 89% to CYP3A81a
MNLIPHLSTGTWILLAVLLVLILL (2)
YGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGMIQFDIECFKKYGR
MWGMYDGRQPVLAIMDPAIIKTILVKECYTNFTNRRNFGLNGPLESAITVAEDEQWKRIR
SVLSPTFTSGKLKEMFQIMKDYSDILVKNVQVSVDKDEPCATKDVIGAYSMDVITSTSFS
VNIDSLQNPSNPFVIHIKNLLKTGFLSPVIIFAVIFPFLRPIFEVLNISFFPKDFTQFFM
NAVTSFREKRKKGDHS (0)
GRVDLLQLMVDSGTTEGNDSSNQHKALTDAEIMAQSLIFIFAGYETTSTALSYLF
YNLATHPDVQQKLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLFPPAGRLERVSK
QNVEINGVIIPKGTVAMIPAYVLQRDPEYWPEPEEFRPERFSKENRATQTPFTFLPFGDG
PRNCIGLRFALLSMKVAIATLLQNFSVRPCAETLIPMEFSTIGVLQPKKPIVLKFLSRAAAHE*
CYP3A83 Xenopus tropicalis (Western clawed frog)
CX982440.1 DT453227
UCSC Browser scaffold_320:299565-317579 Aug. 2005 (xenTro2) assembly
60% to 3A80 chicken, 56% to 3A81 57% to 3A82
96% to 3A120, 91% to 3A121, 89% to CYP3A83a
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYKLFKRYGIPGPTPIPFIGTFL
GNRHGLMEFDMECFKKYGKVWGIYEGQKPLLAIVDPVIIKSIMVKECYTNFTNRRDFGLS
GPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPLMNHYGELLVKNIHKKINNKEPLD
MKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLISILCPFLVP
LLDKMNFCFLSLKILNFFKDAVASIKKKRQKGTH
EDRVDFLQLMVDAQSNEGKSVPEEEKHGYKE
LSDTEILAQSLIFIMAGYETTSTTLMFLAYNIATHPDVQRKLEEEIDALLPNKAPPTYDA
LMKMEYMDMVINESLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHLNPEIWP
EPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKVALTILLQNFRLETCK
DTPVPLKICTKGYLKPTKPIILNLIPKVGQTVEE*
CYP3A83a Xenopus laevis
AAH84827.1 GenPept
89% to 3A83, 89% to 3A120, 88% to 3A121
formerly CYP3A124
renamed CYP3A83a, presumed ohnolog to CYP3A83b (91%)
CYP3A83a and CYP3A83b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A83, CYP3A120 and CYP3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE
CYP3A83b Xenopus laevis
EST EG565461.1
91% to CYP3A83a
CYP3A83a and CYP3A83b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A83, CYP3A120 and CYP3A121
GIMKFDMECFKKYGKVWGFYDGPQPVLAIVDPVIIKSIMVKECYNNFTNRRDFGLSGPLK
SSVFLSKDDHWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIQKKIDNNEPLDMKDI
FGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLLT
CYP3A84P dog pseudogene between SDK1 and FOXK1
UCSC browser chr 6
The human pseudogenes CYP3A-se1[2] and CYP3A-se2[5]
are in a syntenic location with this pseudogene
16005702-16005782 (+) strand aa 47-73 exon 1
ISNTCCFLQGFCDFDEKCFRKYARTWG
16125771-16125865 (-) strand aa 74-105 exon 2
IIYRGRQPVLVILGSLLFMRVLVKEFYILFTNR
16124466-16124555 (-) strand 112-141 exon 5
XXXXXXGSLESSLIFAKGDKWNWLRTVISWTFASGK
16119415-16119480 (-) strand 177-198 exon 7
GAFSRDVIISISFGVEADPISN
16044198-16044386 (+) strand 219-277
LFLSTIVFTFPALLLKLLNVIQLPKEGQEFFIGSISKMERKASERNLHSKQGLLVEKRQMFLN
16113643-16113882 (-) strand aa 332-419 exon 11
IQEPLHKCLSLQQAAPTCEVLLQVEYLVTV*MTPSGSTSRGMSGRVWKKT
PEGMLVMITIYRLLRHPMHWLEPEESCPER
Cyp3a85-ps rat
GenEMBL NW_001084671.1 4655562-4666355 (-) strand
86% to 3A2 new gene
(numbering is relative, taken from a larger sequence)
missing first four exons on two different contigs
67133 DLGPLGIMSKAITFSKVEEWKRYRAFLSPTFTSGKLKE 67020
66942 MFPIVEQHGDILVKYLRREDEKGKPAPVKQ 66853
VFGAYSMDEITSTSFGVSVD 66373
66372 FLTNPKDTFVEKTKKLLRFDFFDPLFLSVG
63877 LFPFLTPIYEMLNICMFPKDSIAFLQKFVYRMKETRLDSKHK
62887 HRVDFLQLMLNAHNNSKDEVSHK 62819
60567 ALSDVEIIAQSVTFIFAGYEITSSTLSFVLYSLATYPDIQKKLQEEIDGALPNK 60406
58571 APPTYDIVMEMEYLDMVLNETLRLYPVGNRLERVCKKDIELGGVFIPKGSVV 58416
58415 MIPTYPLQRDPQHWTEPEEFHPER 58344
56749 FSKENKGSIDPYVFLPFGHGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQ 56588
53720 IPLKLSIQAILEPEKAIVLKVVPWDAVITGA 53628
CYP3A86 catfish
No accession number
David S. Barber, Margaret O. James
76% to CYP3A65, 93% to CYP3A87
intestine
CYP3A87 catfish
No accession number
David S. Barber, Margaret O. James
76% to CYP3A65, 93% to CYP3A86
liver
CYP3A88X Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
86% TO 3A22 AND 3A39v1, 76% to human 3A4 and 3A5
partial seq.
name changed to CYP3A46 after whole sequence known
CYP3A88X Sus scrofa (miniature pig)
3 aa diffs to CB479861.1 EST, probably the same seq.
F22946.1 extends seq toward N-term.
AJ959509.1 overlaps F22946 with 1 aa diff in 42
Be aware this may be a hybrid of two or more gene sequences.
BP447724.1, DB797665.1, DB798166.1, DB798326.1, DB799120.1
DB799225.1
92% to 3A39v1
name changed to CYP3A46
MDLIPGFSTETWVLLATSLVLLYLYGTYSHGLFKKLGIPGPRPLPYF
GNILGYRKGVDHFDKKCFQQYGKMWG
FFDGRQPVLAITDPDMIKTVLVKECYSVFTNRRSFGPRGAMRSAVSLAEDEEWKRIRTLL
SPTFTSGKLKEMFPIISHYGDLLVSNLRKEAEKGKPVTMKDIFGAYSMDVITSTAFGVNV
DSLNNPQDPFVENSRKLLKFSFFSPFFLSIIFFPFLTPILEVLNITLFPKSVVNFFTRSI
KRMKESRLKDTQKHRVDLLQLMINSQNSKEMDAHKGL
SNEELVAQGVIFIFAGYETTSSSLSLLVYKLATHPDVQQKL
QEEIDATFPNKAPPTYDGLAQMEYLD
MVVNESLRIFPVTPRVERVCKKDVEIHGVFVPKGTVMMVPIFALHRAPELWPEPEEFRPE
RFSKKNKDTINPYTYLPFGTGPRNCIGMRFALMNMKLALVRVLQNFSFKPCKETQIPLKI
SSQGLIQPEKPIVLMVVPRDGTTSGA*
CYP3A89 horse
EU014892
Heather Knych
Submitted to nomenclature committee June 22, 2007
79% to 3A74 cow, 80% to CYP3A4 and CYP3A5 human
80% to CYP3A39v1 pig
CYP3A89 horse
UCSC Browser chrUn:228948991-228982779, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca2
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYHKGIWDFDKKCFEKYGKMWGTYHGTKPVL
AITDPDMIKTVLVKECYSVFTNRRPFGPFGFMKSAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPILGQYGDVLVRNLKKEA
EKGKPITLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLFSFDFLDPLLLSITLFPFLNAVFEVLNVFVFPKSVT
DFFIKSVKRMKESRLKDKEKHRVDFLQLMINSQNSKELDTHKALSDLELVAQSIIFIFAGYETTSSSLSFLMYFLATHPDVQ
QKLQEEIDVTFPNKAPPTYDALVQMEYLDMVLNESLRLFPIAVRLERVCKKDVEINGVFIPKGTVVMVPTFALHKHPEFWPE
PEEFRPERFSKENKDSINPYIYLPFGAGPRNCIGMRFALMNMKLALVRMLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVSGA
CYP3A90 Callithrix jacchus (marmoset)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Cja3a5a
87% to 3A5 human, paralog of CYP3A5
CYP3A91 Otolemur garnettii (galago)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oga1
82% to 3A92, 79% to 3A98 dog, 79% to 3A4 human, 78% to 3A5 human
CYP3A92 Otolemur garnettii (galago)
No accession number
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oga2
82% to 3A5 human, 83% to 3A4 human,
82% to 3A91, 80% to 3A98 dog
CYP3A93 horse
UCSC Browser chrUn:228891415-228923288, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca1
MDLIPSFSTETWVLLATSLVLIYLYGTYTHGLFKKLGIPGPTPLPFFGNVLSYRKGIWNFDRKCFKKYGKMWGVYDGRRPVL
AVTDPDMIKTVLVKECYSVFTNRRPFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKPVTLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLMVLFPFLQPIFEVLNISLFPKSAI
DFFTKSVKRMKESRLKDKDKHRVDFLQLMINSQNSKELDTHKGLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQ
QKLQEEIDAIFPNKAPPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFSLHRASEFWPE
PEEFRPERFSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQIPLKLGNQGLLQPQKPIVLK
VESRDGTVNGA
CYP3A93 horse
AAWR02042202.1 (+) strand
WGS section of NCBI
79% to CYP3A5
23223 MDLIPSFSTETWVLLATSLVLIYL (2) 23294
27388 YGTYTHGLFKKLGIPGPTPLPFFGNVLSYRK (0) 27480
29587 GIWNFDRKCFKKYGKMWG (2) 29640
30212 VYDGRRPVLAITDPDMIKTVLVKECYSVFTNRR (0) 30310
35597 PFRPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKE (0) 35710
35974 MFPIIGQYGDVLVRNLRKEAEKGKPVTLKD (1) 36063
37396 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENSNKLLRFDFLNPLILLM 37542
40831 IVLFPFLQPIFEVLNISLFPKSAIDFFAKSVKRMKESRLKDKDK 40962
42047 HRVDFLQLMINSQNSKELDTHK 42112
45520 GLSDLELVAQSIVFIFAGYETTSTSLSFLLYLLATHPDVQQKLQEEIDAIFPNK 45681
46292 APPTYDALVQMDYLDMVLNESLRLFPVAVRLERVCKKDAEINGVFIPKGTVVMVPTFS 46465
46466 LHRASEFWPEPEEFRPER 46519
52681 FSKKNKDNINPCIYMPFGNGPRNCIGMRFAMVNMKLALVRVLQNFSFKPCKETQ 52842
54999 IPLKLGNQGLLQPQKPIVLKVESRDGTVNGA* 55094
CYP3A94 horse
UCSC Browser chrUn:229025212-229061564, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca3
MDLIPSFSMETWVLLATSLVLLYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYLKGFWDFDKKCFKKYGSMWGIYDGPQPVL
AITDPDMIKTVLVKECYSVFTNRRSLGPVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKET
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSITLFPFLKAVFEVIHIYMFPKRVT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQDEIDVTFPNKALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFILHRASEFWPE
PEEFCPERFSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKIGNQGLIQPQKPIVLK
VESRDGTWNGA
CYP3A94 horse
AAWR02042203.1 78309-114672 (+) strand
WGS section of NCBI
78309 MDLIPSFSMETWVLLATSLVLLYL (2)
82015 YGTYTHGLFKKLGIPGPTPLPFLGTVLGYLK (0) 82107
84003 GFWDFDKKCFKKYGSMWG (2) 84056
84650 IYDGPQPVLAITDPDMIKTVLVKECYSVFTNRR (0) 84745
88583 PVGFMKNAISLSEDEQWKRIRTLLSPTFTSGKLKE (0) 88687
88948 MFPIIGQYGDVLVRNLRKETEKGKPVTLKN (2) 89037
90379 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFNFLDPFFLSI (1) 90525
95603 TLFPFLKAVFEVIHIYMFPKRVTDFFTKSVKRMKESRLKDKQK (0) 95731
96393 HRVDFLQLMINSQNSKEMDTHK (1) 96458
99613 ALSDLELVAQSIIFIFAGYETTSTSLSFLMYLLATHPDVQQKLQDEIDVTFPNK (0) 99774
109466 ALPTYDTLLQMEYLDMVLNESLRLFPIAGRLERVCKKDVEINGVLIPKGTVVMVPTFI 109639
109640 LHRASEFWPEPEEFCPER 109683 (2)
112163 FSKNNKDNINPYIYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQ (0) 112324
114577 IPLKIGNQGLIQPQKPIVLKVESRDGTWNGA* 114672
CYP3A95 horse
UCSC Browser chrUn:229104699-229137172, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca4
MDLIPSLSMETWVLLATSLVLLYLYGTYSHGHFKKLGIPGPTPLPFFGTVLGYIKGVLAFDKKCFKKYGKMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKPITMKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSILFFPFLIPVYEALNIFVFPKCVT
DFFIKSVKKMKESRLKDKAKQRVDFLQLMINSQNSKEIDNLKVLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQ
QKLQEEIDATFPNKAPPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVLHQHPEFWSE
PEEFRPERFSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQIPLKLVSQGLIRPEKPIVLK
VESRDGTMSGA
CYP3A95 horse
AAWR02042203.1 157804-190276 (+) strand
WGS section of NCBI
157804 MDLIPSLSMETWVLLATSLVLLYL 157875 (2)
161963 YGTYSHGHFKKLGIPGPTPLPFFGTVLGYIK 162055 (0)
163958 GVLAFDKKCFKKYGKMWG 164011 (2)
168704 FYDGRQPVLAITDPDMIKTVLVKECYSVFTNRR 168802 (0)
172355 SFGPMGLMKNAITIAEDEKWKRIRTLLSPTFTSGKLKE 172468 (0)
172730 MFPIIGQYGDMLVRNLRKEAEKGKPITMKE 172819 (2)
174148 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFHFLDPFFLSI 174294 (1)
178624 LFFPFLIPVYEALNIFVFPKCVTDFFIKSVKKMKESRLKDKAK 178752 (0)
179820 QRVDFLQLMINSQNSKEIDNLK 179885 (1)
183504 VLSDLELVAQSITFIFAGYEPVSTSLSFLLYLLATHPDVQQKLQEEIDATFPNK 183665 (0)
186095 APPTYDALVQMEYLDMVLNETLRLFPIADRLERVCKKDVEINGVFIPKGTTVMMPIFVL 186271
186272 HQHPEFWSEPEEFRPER 186322 (2)
187860 FSKKNKDSINPYTYLPFGTGPRNCIGMRFAIVNIKLAVVRVLQNFSFKPCKETQ 188021 (0)
190184 IPLKLVSQGLIRPEKPIVLKVESRDGTMSGA* 190279
CYP3A96 horse
UCSC Browser chrUn:229197172-229225636, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca5
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGFDTECLKKYRKMWGFYDGRQPVL
AITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEA
EKGKPIALKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFLFPKSVT
DFFTKSVKRIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQ
QKLQEEIDATFPNMAPPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFALHRDTELWPQ
PEEFHPERFSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQIPLKLVTYGFLQPEKPIVLK
VESRAGTVSGA
CYP3A96 horse
FJ755695
Heather Knych
Submitted to nomenclature committee Jan. 30, 2009
Equine CYP450 Proposed Sequence 47
72% to CYP3A4, lower case region out of frame
77% to CYP3A4, 84% TO CYP3A89 if frame restored
note: this seq has 12 diffs to the genomic sequence
5 diffs are in the frameshifted region
MDLIPSFSVETWVLLATSLALLYLYGIYTHGLFKKLGIPGPKPLPFLGTLLGYRKGFGGF
DTECLKKYRKMWGFYDGRQPVLAITDPDLIKTVLVKECYSVFTNRRSFGPVGFMKNAISI
SEDEQWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLKKEAEKGKPIALKDIFGAYS
MDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSITIFPFLNPVFELLNIFL
FPKSVTDFFTKSVKGIKESRLKDKEKQRVDFLQLMINSQNSKEMDTHKALSDLELVAQSI
IFIFAGYEpsavlfflfcifwpltlmssrscrrrlmqlppiwhlPTYDALVQMEYLDMVL
NESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFVLHRDTELWPQPEEFHPERFS
KENKDSINLYIYMPFGNGPRNCIGMRFVLMNMKVAVVRVLQNFSFNPCKETQIPLKLVTY
GFFHPEKPIVLKVESRAGTVSGA*
More P450-like translation of the lower case region
XSSSLLSFLYLLATHPDVQQKLQEEIDATSPNMAP
CYP3A96 horse
AAWR02042203.1 250268-278726 (+) strand
WGS section of NCBI
250268 MDLIPSFSVETWVLLATSLALLYL (2) 250339
253991 YGIYTHGLFKKLGIPGPKPLPFLGTLLGYRK (0) 254083
256253 GFGGFDTECLKKYRKMWG (2) 256306
256882 FYDGRQPVLAITDPDLIKTVLVKECYSVFTNRR (0) 256980
260533 SFGPVGFMKNAISISEDEQWKRIRTLLSPTFTSGKLKE (0)
260908 MFPIIGQYGDVLVRNLKKEAEKGKPIALKD (2) 260997
262303 IFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFILSI (1) 262449
267216 TIFPFLNPVFELLNIFLFPKSVTDFFTKSVKRIKESRLKDKEK (0) 267344
268416 QRVDFLQLMINSQNSKEMDTHK (1) 268481
271703 ALSDLELVAQSIIFIFAGYEPVSSSLSFLLYLLATHPDVQQKLQEEIDATFPNM (0) 271864
274219 APPTYDALVQMEYLDMVLNESLRLFPVAGRIERTCKKDVELGGVFIPKGTVVMVPSFA 274392
274393 LHRDTELWPQPEEFHPER (2) 274446
275949 FSKENKDSINPYIYMPFGNGPRNCIGMRFALMNMKVAVVRVLQNFSFKPCKETQ (0) 276114
278634 IPLKLVTYGFLQPEKPIVLKVESRAGTVSGA* 278729
CYP3A97 horse
UCSC Browser chrUn:229268263-229304613, Jan. 2007 (equCab1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
eca6
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDFDKKCFKKYGKTWGFYEGRLPVL
AITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAIIRSEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEA
EKGKPVTLKNIFGAYSMDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISVFPKSVT
DFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSIVFIFAGYETTSTSLSFLMYLLATHPDVQ
QKLQKEIDVTFPNKVPPTYDALLQMDYLDMVLNESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPE
PEEFRPERFSKENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTEAIVKPQKPIVLK
VEPRDGTMTGA
CYP3A97 horse
FJ755696
Heather Knych
Submitted to nomenclature committee Feb. 16, 2009
Equine CYP450 Proposed Sequence 43
85% TO CYP3A89, 76% to seq 47, 75% to CYP3A5
MDLIPNFSTETWVLLATSLVFLYLFGTYTHGLFKKLGIPGPTPLPFFGNILSYRKGIWDF
DKKCFKKYGKTWGFYEGRLPVLAITDPDMIKTVLVKECYSVFTNRRTFGPEGFMKNAITR
SEDEQWKRIRTLLTPTFTSGKLKEMFPIIGHYGDVLVRNLRNEAEKGKPVTLKNIFGAYS
MDVITSTSFGVNIDSLNNPQDPFVDNAKRLLRLDFLDPLILSITLFPFLRPVYEALNISV
FPKSVTDFFIKSVKRMKESRLKNKETNRVDFLQLMINSQNSKEMDTHKALSDLELVAQSI
VFIFAGYETTSTSLSFLMYLLATHPDVQQKLQKEIDVTFPNKVPPTYDALLQMDYLDMVL
NESLRLFPVAGRLQRICKKDVELNGVFIPKRTLVTVPTFVLHRASEFWPEPEEFRPERFS
KENKDSINPYIYLPFGTGPRNCIGMRFALMNMKLAVVRVLQNFSFKPCKETEIPIKLGTE
AIVKPQKPIVLKVEPRDGTVTGA*
CYP3A98 Canis familiaris (dog)
XP_536868.2 GenPept
95% to CYP3A12, 91% to 3A26
MDLIPSFSMETWLLLATSLVLLYLYGTYTHGVFKKLGIPGPTPLPFVGTALGYRKGFSVFDENCFRKYGRMWGFYDGRQPVL
AITDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAISLSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDVLVRNLRKEA
EKGKSINLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENIKKLLKFDFLDPFFFSILLFPFLTPVFEVLNIWLFPKSVT
DFFTKSVKRMKENRLKDKQKHRVDFLQLMINSQNSKETDTHKALSDLELVAQSIIFIFAGYETTSTSLSFLMYELATHPDVQ
QKLQEEIDATFPNKALPTYDALVQMEYLDMVLNETLRLYPIAGRLERVCKKDVEISGVFIPKGTVVMVPTFTLHRDQSLWPE
PEEFRPERFSRKNKDSINPYTYLPFGTGPRNCIGMRFAIMNMKLALVRVLQNFSFKPCKETQIPLKLNAQGIIQPEKPIVLK
VEPRDGSVNGA
CYP3A99 Canis familiaris (dog)
XP_546969.2 GenPept
95% to seq a + f from dog page, (exons 10, 11 do not match)
87% to 3A12, 85% to 3A26
MDLIPSFSTETWLLLATSLVLFYLYGTYTHGLFKKLGIPGPTPLPFLGTVLGYRNGFCDFDEKCFRKYGRMWGFYDGRQPVL
AIMDPDMIKTVLVKECYSVFTNRRSFGPVGFMKSAITVSEDEEWKRIRTLLSPTFTSGKLKEMFPIIGQYGDMLVRNLRKEA
EKGKAISLKDIFGAYSMDVITSTSFGVNIDSLNNPQDPFVENAKKLLKFDFPDPFLLSIILFPFLTPLYEMLNIWLFPKKIT
DFFTKSVKRMKESRLKDKQKHRVDFLQLMINSQNSKEMNTHKALSDLELVAQSIIFVVAGYETTSTSLCLLMYELATHPDVQ
QKLQKEIDATFPNKAAPTYDTLVQMEYLDMVLNESLRLYPITGRLVRVCKKDVEISGVFIPKGTVVMVPTFTLHQDPDIWPE
PEKFQPERFSKKNKDSINPYTYLPFGTGPRNCLGMRFAIMNMKLALIKVLQNFSFKPCKETQIPLKLSSQGLIRPEEPIILN
VEPRDGSVRGA
CYP3A100 Bos taurus (cattle)
XP_584699.3 GenPept
95% to 3A74, 91% to 3A76, 80% to 3A28
MELIPSFSMETWVLLSISLVLLYLYGTYSHGLFKKLGVPGPRPLPYFGNVLSYRKGVCEFDEECFKKYGKMWGIFEGKHPLL
VITDPDVIKTVLVKECYSVFTNRKVFGPRGIMKNAVSVAEDEQWKRIRTLLSPAFTSGKLKEMFPIIGKYGDVLVRNLRKEA
EKGKSVNMKEVFGAYSMDVITSTSFGVNIDSLGNPQDPFVENAKKLLRFDILNPFLLSVVLFPFLVPILDVLNITIFPKSAV
NFFTKSVKRIKESRLKDNQKPRVDFLQLMINSQNSKETDNHKALSDQELIAQSIIFIFAGYETTSSTLSFLLYILATHPDVQ
QKLQEEIDATFPNKAPPTYDVLAQMEYLDMVVNETLRMFPIAIRLERLCKKDVEIHGVSIPKGTTVMVPISVLHKDPQLWPE
PEEFRPERFSKKNKDSINPYVYLPFGTGPRNCIGMRFAIMNMKLAIVRVLQNFSFKPCKETQIPLKISSQGVLRPEKPVVLK
VVLRDGTISGA
CYP3A101 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80414036-80431004
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo2
89% to CYP3A102, 89% to 3A104, 89% to 3A103, 88% to 3A105, 69% to 3A89
IFTLPYRYGTRTHKLFKNLGIPGPTPLPFIGTVLSYHKGIEGFDYGCFKKYGKTWGFFDGTKPVLAIMDPETIKTVMVKECY
SVFTNRRMLGLSGILEKAISIAEDEQWKRMRTVLSPAFTGGKLKEMFPIIKQYGDVLVKNMKKEAEKSKPVTLKDILGAYSM
DVITSTSFGIHVDSLNNPNDPFVRKIRKLIRFSFRDPLILSIVIFPFLIPLFKKLDITIFSKDVTDFLAKSILKIKEERKKT
EKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYESTSSVLCFLFYQLATNPGIQEKLQKEIDAFLPNKEA
VTYDALVQMEYLDMVINENLRLYPITGRIERIAKKPVELNGLMIPKGTVVMAPPYVLHRDPEYWPEPEEFRPERFSKENKES
INPYVYLPFGVGPRNCLGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSYRPLLAPSVPIVLQAVLRNKKGNQH
CYP3A102 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80549861-80580975
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo3
90% to 3A104, 89% to 3A103, 89% to 3A105, 89% to 3A101, 80% to 3A106
MNIIPNLSAGTWTLIILFLTILYLYGTRTHKLFKNIGIPGPTPFPFIGTILYYRKGIVGFDYGCYKKYGKTWGFFDGTKPVL
AIMDPETIKTVLVKECYSVFTNRRMLGLSGILEKAISIAEDEEWKRIRTVLSPAFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDIIISTSFGIHVDSLNNPNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFSKDAT
DFLGKSILRIKEERKKSTEKHRVDFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIVFIFAGYESTSSVLSFLFYHLATNLE
IQEKLQKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLYPISGRIERIAKKTVQLNGLTIPQGTVVMTPPYVLHRDPEYW
PEPEEFRPERFSKENKESINPYVYLPFGAGPRNCIAMRFALMGMKVAVSRLLQEFSFIPCKETPIPLKLNNQPLLTPSVPIV
LQAVLRNKKGNQH
CYP3A103 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80611887-80640626
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo4
99% to 3A105, 99% to 3A104, 89% to 3A102, 84% tpo 3A106
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A104 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80672879-80701151
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo5
99% to 3A103, 98% to 3A105, 90% to 3A102, 89% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGILEKAISIAEDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIRKLIRFSFLDPLILSITIFPFLIPLFKKLDITVFPKEAT
DFLAKSIIKIKEERKKSTGKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A105 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80734341-80768989
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo6
99% to 3A103, 98% to 3A104, 89% to 3A102, 88% to 3A101
MNIIPSLSAGTWTLIVLFLTLLYLYGTRTHKLFKNLGIPGPTPLPFFGTVLAYRKGFADFDYGCFKKYGKTWGFFDGRQAVL
AIMDPETIKTVLVKECYSVFTNRRMFGPSGFLEKAISIAKDEQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKSKPVTMKEIFGAYSMDVITSTSFGIHVDSLNNQNDPFVREIKKLIRFSFLDPLILSTTIFPFLIPLFNKLDITVFPKEAT
DFLAKSIIKIKEERTKSTEKANFLQLMMDSQTSKNSESHSQKDLSDEEILAQSIIFIFAGYETTSSVLSFLFYHLATNPKIQ
EKLQKEIDAFLPNKEAVTYDALVQMEYLDMVINENLRLYPIAGRIERVAKKTVELNGLTIPKGTVVMAPPYVLHRDPEYWPE
PEEFRPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMSMKVAVSRLLQEFSFRPCKETQIPLKLSNQPLLTPTVPIVLQ
AELRNKKGNQH
CYP3A106 Monodelphis domestica (opussum)
UCSC Browser Opossum, chr6:80783381-80814644
Jan 2006 (monDom4) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Mdo7 note: this seq has an assembly defect in the middle
85% to 3A105, 84% to 3A103
MNIIPSLSAGTWTLIVVFLTLLYLYGTRTHKLFKNLGIPGPKPLPFFGTVFSYRKGLVNFDYDCFKKYGKTWGFYDGRQPVL
ATMDPETIKTVMVKECYSVFTNRRSFGPVGSLESAITVAKDDQWKRIRTVLSPTFTSGKLKEMFPIINQYGDVLVKNMKKEA
EKNKPVTMKDILGAYSMDVITSTSFGIHVDSLNNPNDPFVREIKKLIRFNFLDPLILSVAIFPFLTPLFNKLDITVFPKDAI
NFLAKSLISMFSTIFSALVFILHYFFQHRVDLLQLMMDSQSSKNSEPHSHKDLSDQEILAQSIIFLFAGYETTSSVLSFLFY
HLATNPEIQEKLHKEIDAVLPNKEAVTYDALVQMEYLDMVINENLRLFPIAGRVERVAKKTVELNGLTIPKGTVVMTPPYVL
HREPEYWPEPEKFHPERFSKENKESINPYVYLPFGAGPRNCIGMRFALMNMKVAVSRLLQEFSFRTCKETQVPLKLGNQPIL
TPTIPIVLQAELRNKKTN
CYP3A107 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25769723-25784944, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan1
78% to CYP3A108, 75% to CYP3A109, 71% to CYP3A110, 57% to CYP3A113
MSSILNFSIETWILLGTFLALMILYGIWPFRVFTKSGIPGPRPVPFFGNILEYSQGIIEFDKKCFQKYGKIWRLFEGRQAMV
AVLDLEIIKTVLVKEVFSSFTNRRRIGIEGIMEESIIGAEDEQWKELRILISPTFSSGKLKEMLRIMIHYGEILVKTIWKKA
EKNQNVIVKDYYGAYSLDVITSTSFGVDVNSLNKMNDTYFKEVKKLSSVDFFSPLLALTSIFPFITPLLNLLDISLFPSDSV
EYIKRFVHKIRESRHQDNQQHRADLLKLLLDSQNPKEGLKGKKGLSDTGILAQAVAFVFAGYETTSSALSFISYNLATHPDV
QQKLQEEIDKVLPNKSPLTYDAIVQMEYLDMVINETLRLYPIGPRLERMCKKTLEINGLTIHKGTCVVIPIAVLQHDPNYWT
EPDEFRPERFSKEMREKRDPYTFIPFGVGPRNCIGMRFALLNMKVAIIGLLQNFSLRTCQETQIPLELNSMGFLTPKKPIVL
QFIPRADTKSQD
CYP3A108 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25741772-25760791, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan2
79% to 3A109, 78% to 3A107, 75% to CYP3A110, 56% to 3A37 chicken
MSSIFSFSIETWILLGTFLTLMILYGIWPYGVFTKRNIPGPWPVPFLGNIQEYSQGLMVFDKKCSEKYGKIWGLYEGRQAII
AVLDLDIIKKVLVKEVFSSFTNRRNTGIEGILELAVSSAEDEHWKELRTLMSRTFTSGKLKEMLPIMTHYGEVLVRNIWRKA
EKNENVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDTFVKEIKKISSIDFFSPLFALISTFPFMIPLLKLLNINLFPNDSV
EYFKRFLHKVKERRHQDNQQHRVDFLQLMLDSQNPKEGSKGKGGLSDAELLAQAFAFIFAGYETSSNTLSFISYNLATHPDV
QEKLQAEIDTVLPNKSPLTYDALVRMEYLDMVINESLRLYPISSRLERMCKKTTEINGLTIPKGTCVVIPLFILQKDPNYWL
EPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLSIKVAMIGLLKNFSLRTCQETQIPPEINSFGLLTAKKPIVL
RYIPRADTKIKD
CYP3A109 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25693551-25724066, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan3
79% to 3A108, 75% to 3A107, 77% to 3A110, 55% to CYP3A37 chicken
MSSILSFSIETWILLGTFLALMILYGIWPYGVFTKLRIPGPRPIPFLGNILDYSQGMDEFDKKCFQKYGKIWGLYEGRKAKI
AVLDLDIIKSVLVKEVFTNFTNRQMAGIEGIMSESIFSAKDERWKELRTLVSPTFTSGKLKEMVPMMIQYGEVLVKNLQNKV
EKNQNVTIKDYFGAYNLDVITSTSFGVDIDNLNKMNNTFVKEIKKLTSINFFSPLFALISVLPFMIPLLKLLNINTFPNDSV
EYFKRFMDKIKERTQQGNPQQRMNFLQLMLDTQNPKEGLKNKGGLSDAEILAQAFSFIFAGYETSSTTLSFISYNLATHLDV
QKKLQEEIDEVLPNKAPLTYDALVQMEYLDMIINETLRLYTVGSRLERICKKTMKINGLTIPKGMTVVIPVSCLHSDPNYWV
NPDEFHPERFSKEMRDKRDPYTFMPFGAGPRNCIGMRFALLNIKVAIIGLLQNFSLRTCQETQIPLEVNSFGLLTTKKPIVL
RFIPRAEIKSKD
CYP3A110 Ornithorhynchus anatinus (platupus)
UCSC Browser, chr2:25660643-25688288, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan4
77% to CYP3A109, 75% to 3A108, 71% to 3A107, 56% to 3A37 chicken
MRGILNFSIETWILLGSFLTLVILYGIWPFGVFTKLGIPGPRPIPFFGNILEYAQGTMHFDKKCFQKYGKIWGFYEGWKAKI
AVLDLDIIKRVLVKEVFTNFTNRQNSGIEGILKHSVFAAKDKHWKKLRTLISSTFTSGKLKEMVPTIIHYGEILVKNIWYKA
EKNQNVTVKDYFGAYSLDVITSTSFGVDVDSLNKMNDRFVKEIRKLSSVDFFPPIFVLISVLPFITPLLKLLNINIFPNDSV
EYFKRFMDNIKGTHHQGNQQQQVNFLQMMLDTQNPKEGSKAKGVLSDAEILTQAFAFIFAGYESSSSVLSFIAYNLAIHPDV
QQKLQEEIDTVLPNKLPLTYEALVQMEYLDMVINETLRLYSVGPRLQRVSKKTTVINGLTIPKGMTVMIPLTCLHREPKYWL
EPDEFHPEIPLELTARGFLIPQKPIVLQFIPRAEIKKG
CYP3A111 Ornithorhynchus anatinus (platupus)
UCSC Browser, Contig7638:3143-20297, Mar. 2007 (ornAna1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
oan5
66% to CYP3A80 opossum (possible ortholog),
63% to 3A113, 60% to 3A80 chicken
GGLDSSLTIAEYHTWKRIRTIVSPAFTSGKLKEMFPIIKHYGKILVQNIDKKVKKNEPVNMKEIFGSYSLDVVTSTSFGVDI
DSMNNPNDPFVKQINKLLSFTFLSPLILLTVVCPFLVPVFEKMNLSLFPREFLEFFVGVTRNFKEKRQKGVHTGRVDFLQLM
VDSQSSDSNSEPKMTDTEISTQAIIFIFAGFETTSSTLNFVSYNLATHPEVQKKLQEEIDSILPNKASPTYESISQMDYLDM
VVQETLRLFPPGGRIERVCKETIQIKGLTIPKGTVVIIPAFVLHRDPEHWPEPEKFLPERFSKEEKASHNPYVFLPFGAGPR
NCIGMRFALLNMKAALIHLLQNFSVEPCKETPMPLELDSTGFMKPKKPIILKLVPRSGVDSED
CYP3A112 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:62196-70979,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca1
84% to CYP3A113, 69% to CYP3A114, 66% to 3A80 chicken
62% to CYP3A80 Monodelphis domestica, 60% to 3A37 chick
MDFFSFFSIQTWSLLGIFLLLLMLYGIWPYNFFKKLGIPGPRPLPFIGTFLEYNKGVLDFDERCRQKYGKIWGFFDGRQPVM
AIMDPVIIKTILVKECYTHFTNRRDFGLNGDFDASVLVAQDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGEMLVKNVQKKG
ENGEYIDTKDIFGAYSMDVITSTSFSIDIDSINNPKDPFVVSMKKIIKTNFVNPLLLLIVIFPFLRPVLEALNISLAPTSAT
GFLRGALRKIKSDRQKNVHQDRVDFLQLMVDSQISGDVFDGTNSYKALNDREILAQAFTFVFGGYETTSSTLGYMAYCLATH
PDVQKKLQDEIDEVLPDQATPVYDALLQMEYLDMVINETLRLYPPGGRIERVCKNTVEINGVTIPKGTVAMIPAFVLHRDPE
FWPEPEEFRPERFSKENKEFLNPYVFLPFGIGPRNCIGMRFALLSLKVATVVLMQRFSFRTCKETPIPLELESKGFMRPKNP
IRLKFVPRVMAESNE
CYP3A113 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:49268-57033,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca2 Browser is missing first exon in a seq gap
84% to CYP3A112, 68% to 3A80 chicken, 72% to 3A114
61% to 3A37 chick
GIWPYNFFKKLGIPGPRPLPFIGTFLEYRKGVLDFDEMCHKKYGKIWGFFDGREPVMAILDPVIIKTILVKECYTHFTNRRD
FGLNGDFDSSILTVQDEQWKRIRTVLSPNFTSGRLKEMFPIINHYGEMLVKNIQKKVENGEYIDTKDIFGAYSMDVITSTSF
SIDIDSINNPNDPFVTNIKKIVKFNFVNPLLVLIVIFPFLTPVLEALNFSLTPTSVTNFIKESIKKLKKDRQKNLHKDRVDF
LQLMVDSQISGEILDDSKSYKALNDKEILTQAIIFVFAGYETTSSTLSYMAYCLATHPDVQQKLQEEIDEALPNQATPVYEV
LLQMEYLDMVINETLRLYPPGGRIERVCKTTVEINGVTIPKGTVTMIPAFVLHRDPEFWPEPEEFRPERFSKENKETLDPYT
FLPFGAGPRNCIGMRFALLSLKVAMIVLLQRFSFRTCEETPIPLELQSQGFMTPKKPIRLKFVPRVMAESKE
CYP3A114 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:33297-45513,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca3
72% to CYP3A113, 69% to 3A112, 61% to 3A80 chicken
58% to 3A37 chick
YGIWPYNFFKKLGIPGPRPLPFIGTLHKHRIGVNNFDQKSHEKYGKIWGLFDGRQPVIAILDPAIIKIILVKHFYTHFTNRR
DFGLNGELDTSIAITRDEHWKRIRTVLSPNFTSGRLKEMLPIINHYGKILVESAQKKVENGEAIDLKSFFGGYSMDVTTSTS
FSINVDSINNPNDPFVMHIKTFLKFDTFDPVILLVVIFPFLRPLFERLNFNMVAPSSFTTFFIDVLKKVKKDRQKNDHKNRV
DFLQLMVDSQISGNIPEEAKMYKALTDKEILTQAIVFIFAGFETTSTTLSFLSHCLATNPDVQQKLQEEIDATLPDQATPTY
NAIQQMEYLDMVVNETLRLYPVGGRIERDCKNTVEINGVTIPKGTVIVIPTFPLHRDPEYWPEPEEFRPERFSKENKETQNP
YVYLPFGAGPRNCIGMRFALLVVKVAIVVLLQKHTLRPCKETQIPLEVHGQVLLEPKKTIKLKLVRRAGLEE
CYP3A115 Anolis carolinensis (green anole lizard)
UCSC Browser scaffold_533:424-21366,
Lizard Feb. 2007 (anoCar1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
aca5 partial seq
54% to 3A37 chicken
YGIWPYGVFKKLGVPGPTPLPFIGTALAYRNGILQFDKACFKKYGKVWGFYDGRTPVLAVTDPAVIKAVLVKECYTVFTNRR
KFGPTGKLEKAVSLAEDDTWKRIRTVLSPTFTSGKLKEMLPIIQHYAEILIKNFSEKADKGETVDIKDVLGPYSMDVVASSS
FGVNINSMNNPQDPFVKQAKKLVKFNFFSPLFVLMYMVPWLTPVLNKMNITLFSAEAVDFFAKAIGKIKEQRKQEMDKGRVD
FLALMIESQKAEAKTQINGMNQTYKFSKENKGRIDPYVYLPFGAGPRNCIGMRFAFLILKAGAVSLLQNFTFKPCKETQIPM
ELSTTGLMIPKKPIILKAIPRASSSH
CYP3A116 Dicentrarchus labrax (European sea bass)
ABB90404.1 GenPept
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Dla3aX
Possible Ortholog of CYP3A68
87% to 3A68 bass
MGYFFYFSAETWTLLVTLITLFFVYVYWPYGTFKKMGIPGPKPIPFFGTMLAYRKGFMNFDSECFQKYGKTWGIYDGRQPVL
CITDVSMIKTVLIKECYSLFTNRRNFRLNGPLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFGIMKQHSANLISSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDLDSLNNPSDPFVTNIKKMLKFDLFSPLFLIVAFFPFMGPVFEKMEFSFFPTYVT
DFFYAALQKIKSNRETSKQKSRVDFLQLMIDSQKNNDLSGVEQDKGLNDHEILSQAMIFIFAGYETSSSSLTFLAYNLATNP
AVMKRLQQEIDSTFPNKAPIEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVELNGIVIPKDMVVMIPTWPLHRDPDL
WPEPEEFKPERFSKENKETIDPYTYMPFGAGPRNCIGMRFALVMMKLAIVEVLQRYSFSVCKETEVPFEMDIQGLLMPKRPI
KLKLEPRSEPSS
CYP3A117 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4870920-4874088, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33062
Paralog of CYP3A68
93% to 3A119, 93% to 3A118, 81% to 3A68 bass,
81% to 3A68 Dicentrarchus
MGFSLFLSAETWTLLVALVTLLFMYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFEGRQPVL
CITDPAMIKTILIKECYSLFTNRRNTRLNGQLHDALTVAENHQWRRIRSVLSPSFTSGKLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKLLNIDFFSPVFLIVAFFPFLGPIMEKMEFSLFPKSVT
DFFYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIVPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSL
WPEPEAFKPERFSKENKDSIDHYTYMPFGAGPRNCIGMRFALMMMKLAMVEILQRFSLSVCKETEIPLEMDTQAVVMPKRPI
KLKLVSR
CYP3A118 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4859354-4863677, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33063
Paralog of CYP3A68
95% to 3A119, 93% to 3A117, 83% to 3A68 bass
MGFSLFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGIPGPQPIPFFGTMLAYRKGITTFDEDCSKKYGKVWGIFDGRQPVL
CITDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWRRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKA
DKDEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDILSPLFLIVAFFPFLGPIMEKMEFSFFPKSVT
DFFYSALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSTLSFLAYNLATNP
HIMKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIILRLERVAKATVEINGIVIPKDMVVAVPTWPLHRDPSL
WPDPEAFKPERFSKENKESIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVENLQRFSFSVCKETEIPLEMDVQDLLMPKRPI
KLKLVSR
CYP3A119 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4853058-4857963, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33064
Paralog of CYP3A68
95% to 3A118, 93% to 3A117, 87% to 3A68 bass,
86% to 3A68 Dicentrarchus
MGFFLSAETWTLLVALVTLLFVYVCWNFGIFKKLGVPGPQPIPFFGTMLAYRKGFTTFDEDCSKKYGNVWGIFDGRQPVLCI
TDPAMIKTILIKECYSLFTNRRNFRLNGQLYDAVSIAEDDQWKRIRSVLSPSFTSGRLKEMFDIMKHHSANLTSSMKKKADK
DEPLELKEFFGPYSMDVVTSTAFSVDIDSLNNPSDPFVANIKKMLKFDFFSPVFLIVAFFPFMAPILEKMEFSFFPKSVTDF
FYAALQKIKSNRVHSEQKSRVDFLQLMIDSQKNIDLSKEESNKGLSDHEILSQAMIFLFAGYETSSSSLSFLAYNLARNPHI
MKRLQEEVDSTFPNKGPVEYQALMQMEYLDSVINESLRLYPIAPRLERVAKATVEINGIVIPKDMVVMVPTWPLHRDPSLWP
EPEAFKPERFSKENKDSIDPYTYMPFGAGPRNCIGMRFALVMMKLAMVEILQRFSFSVCKETEIPLEMDVQGLLMPKRPIKL
KLVPR
CYP3A120 Xenopus tropicalis (Western clawed frog)
UCSC Browser scaffold_320:325056-341660, Aug. 2005 (xenTro2) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Xt3202
96% identical to CYP3A83, adjacent on chr, 90% to 3A121
MTFLPDFSMATWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRKGLMEFDMECFKKYGKVWGIYEGQKPLL
AIVDPVIIKSIMIKECYSNFTNRRDLGLTGPLKSSVLVSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKHIFGSYSMDIVLSTSFSVNVDSMNNPNDPFVTNARNLFKFSFFNPLFLIAILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKGTHEDRVDLLQLMVDAQSNEGESVPEEEKHGYKELSDTEILAQSLIFIMAGYETTSTTLMFLAYNI
ATHPDVQRKLEEEIDALLPNKAPPTYDALMKMEYMDMVINETLRMFPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNMKLVLTILLQNFRFETCKDTPVPLKICTDGYLKP
TKPIILNLIPKAGQTVEE
CYP3A121 Xenopus tropicalis (Western clawed frog)
UCSC Browser scaffold_320:348830-370189 Aug. 2005 (xenTro2) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Xt3203 adjacent to CYP3A120, 91% to 3A83, 90% to 3A120,
88% to CYP3A83a
MTFLPDFSKETWTLLVLLLTLLAYYAIWPYRLFKRYGIPGPTPIPFIGTFLGNRHGLMEFDMKCFKKYGNVWGFYDGPQPVL
AILDPVIIKSIMVKECYTNFTNRRDFGLSGPLKSSVLMSKDEQWKRIRTVLSPTFTSGKLKQMFPLMKHYGELLVKNIHKKI
DNKEPLDMKSIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFKPLFLITILCPFLVPLLDKMNFCFLSSKFL
KFFKDAVASIKKKRQKGAHMDRVDFLQLMVDAQSNEGESVPEEEKHRHKELSDTEILAQSLIFIMAGYETTSTTLMFLTYNI
ARYPDVQRKLEEEINTLLPNKAPPTYDALMKMEYMDMVINETLRLLPPAIRIDRVCKKTMEINGVTIPAGVVIVVPLFALHL
NPEIWPEPEEFQPERFSKENQKNQDPYNFLPFGVGPRNCIGMRFALVNIKLALTILLQNFKLETCKDTPVPLKVCTRGNLKP
TKPIILNLVPKGAQTTEEQI
CYP3A122X Xenopus tropicalis (Western clawed frog)
UCSC Browser scaffold_76:34838-54675, Aug. 2005 (xenTro2) assembly
98% to 3A82 (different scaffold, but possible allele)
92% to 3A81, 90% to CYP3A81b, 90% to CYP3A81a
renamed CYP3A82v1, adjacent to CYP3A81
MNLIPHLSTG TWILLAVLLV LILLYGIWPY GLFKKMGIPG PTPLPFIGTF LEFRKGMIQF
DIECFKKYGR MWGMYDGRQP VLAIMDPAII KTILVKECYT NFTNRRNFGL SGPLESAITS
AEDEQWKRIR SVLSPTFTSG KLKEMFQIMK DYSDILVKNV QVYVDKDEPC ATKDVIGAYS
MDVITSTSFS VNIDSLQNPS NPFVIHIKNL LKTGLLSPVI ILVVIFPFLR PIFEVLNISF
FPKNFTQFFM NAVTSFREKR KKGDHSGRVD LLQLMVDSGT TEGNDLSNQH KALTDAEIMA
QSVIFIFAGY ETTSTALSYL FYNLATHPDV QQKLHEEIDS FLPDKASPTY DILMQMEYLD
MVIQETLRLF PPAGRLERVS KQNVEINGVS IPKGTVAMIP AYVLQRDPEY WPEPEEFRPE
RFSKENRATQ TPFTFLPFGD GPRNCIGLRF ALLSMKVAIA TLLQNFSVRP CAETLIPMEF
STIGVLQPKK PIVLKFLSRA AAHE
CYP3A123X Xenopus laevis
AAH60496.1 GenPept
90% to CYP3A82v1, 90% to CYP3A81a, 89% to 3A82, 88% to CYP3A81
renamed CYP3A81b, presumed ohnolog to CYP3A81a (90%)
CYP3A81a and CYP3A81b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGLFKKMGIPGPTPLPFIGTFLEFRKGLVQFDTECFKKYGKTWGLYDGRQPVL
AIMDPAIIKTILVKECYTNFTNRRNFGLSGPLESAITAAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQDNV
GKDEPCTMKDVIGAYSMDVITSTSFSVNIDSLKNPSHPFVVHIKNLLKGGLLNPLIILVVVFPFLRPIFEGLNINFFPKNFT
QFFTNAVTSFREKRKKGDHTGRVDFLQLMVDSSVTEGNDSGNQHKALTDVEIMAQSIIFIFAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPDKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNIEINGVSIPKGTVTMIPAYVLQRDPDY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVSMLQNFSVRPCAETLIPMEYSTIGVLQPKKPI
VLKFLSRTSAQE
CYP3A124X Xenopus laevis
AAH84827.1 GenPept
89% to 3A83, 89% to 3A120, 88% to 3A121
renamed CYP3A83a, presumed ohnolog to CYP3A83b (91%)
CYP3A83a and CYP3A83b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A83, CYP3A120 and CYP3A121
MTFLPDFSMETWTLLVLLLTLLAYYAIWPYRLFKRHGIPGPTPIPFIGTFLGNRNGIMEFDMECFKKYGNVWGFYDGPKPLL
AIVDPVIIKNIMIKECYTNFTNRRDFGLSGPLKSSVLISKDEQWKRIRTVLSPTFTSGKLKQMFPVMKHYGELLVKNIQKKI
DNKEPLNMKYIFGSYSMDTILSTSFSVNVDSMNNPNDPFVTNARNLFTFSFFNPLFLLTILCPFLVPLLDKMNFCFLSLKIL
NFFKDAVASIKKKRQKDIHEDRVDFLQLMVDAQNNEGDSVPEGEKQRYKELSDDEILAQSLIFIMAGYETTSTTLMFLAYNI
AMHPDVQSRLEEEIDTLLPNKAPPTYEALMKMEYMDMVINETMRLFPSAIRIDRVCKKTMEINGVTIPAGVVIVVPLFVLHL
NPEVWPEPEKFQPERFSKENQKNQDPYSFLPFGTGPRNCIGMRFALVNMKLALTLLLQNFRFEKCEDTPDPLNICTKGYLKP
TKPIILKLVPKTAQTMKE
CYP3A125X Xenopus laevis
AAI29607.1 GenPept
94% to CYP3A81 (possible ortholog),
90% to CYP3A81b, 90% to CYP3A82v1, 89% to 3A82
renamed CYP3A81a, presumed ohnolog to CYP3A81b (90%)
CYP3A81a and CYP3A81b are probable co-orthologs to the
Xenopus tropicalis tandem gene cluster CYP3A81, CYP3A82v1
MNLIPHLSTGTWILLAALFLLILLYGIWPYGFFKKMGIPGPTPLPFIGTFLEFRKGMVQFDTECFKKYGKMWGTYDGRQPVL
AVMDPAIIKTILVKEFYTNFTNRRNFGLNGPFEFAITIAEDEQWKRIRSVLSPTFTSGKLKEMFQIMKDYSDILVKNIQGYV
DKDEPCATKDVIGAYSMDVITSTSFSVNIDSLNKPSDPFVIHMKKLLTTGLMSPVLILVVIFPFLRPILEGLNLNFVPNDFT
QFFMNAVTSFREKRKKGDHSGRVDLLQLMVDSRTTEGNDLSNQHKALTDAEIMAQAVIFIVAGYETTSTALSYLFYCLATHP
DVQQRLHEEIDSFLPNKASPTYDILMQMEYLDMVIQETLRLYPPAGRLERVSKQNVEINGVSIPKGTVTMIPAYVLQRDPEY
WPEPEEFRPERFSKENRETHTPFTFLPFGDGPRNCIGMRFALLSMKVAIVTMLQNFSVRPCAETLIPMEFSTIGFLQPKKPI
VLKFLSRTSAQE
CYP3A126 Pimephales promelas (Fathead minnow)
No accession number
Roger Meier
Submitted to nomenclature committee Dec. 29, 2007
81% to CYP3A65 Danio
CYP3A127 Gobiocypris rarus (a rare minnow)
GenEMBL EU106659
Jiayin Dai
Submitted to nomenclature committee 4/19/2008
70% to trout CYP3A27
CYP3A128P horse
AAWR02042203.1 386095-397052 (+)
Pseudogene beginning with exon 8, & = frameshift
386095 AVFPFLKPVFEA*NIFLFPKSVLDFFTKSIKx & xKESRHKDKQK (0) 386222
387533 Q*VDFLQMIT & SQNSKDMDTHK (1) 387597
390790 ALSDLELVAQSIIFIFGGYEPTSSNFSFLMYALATHPDVQQKMQEEIDVTFPNK (0) 390951
395473 APPTYEVLIQMKYLDMVINESLRLFPVTFRLERVGKKDV*ISGVFITKGTVVMVPT 395640
395641 FILHRDLELWQEPEEFHPER (2) 395700
396957 MPMKFGIQGLLQPQKPTVVKVESRDGTACGL* 397052
CYP3A129 horse
AAWR02042203.1 (-) strand
WGS section of NCBI
453729 MNLIPSFSTDTWVLLATILGLLYL (2)
YGTYTHGLFKKLGIPGPTPLPFLGNVLSYRK (0)
GFWDFDKTCFKKYGKIWG (2)
445287 FYDGRQPVLAITDPEMIKTVLVKECYSLFTNRR (0)
PVGPVGILKSSITLSEDEQWKRMRTLLSPTFTSGKLKE (0)
MFPTISQYGDVLVRNLRKEAEKGMPITLKE (2)
440191 FFGAYSMDVITGISFGVNIDSLNNPQHRFVENCKNILKFHFFDPLTILL (1) 440045
ALLPFLSPVLEVLNILVFPVSAIKFFTKSIKTIKESRLKDKQK (0)
QQVDFLQLMINSQNSKEMSRYK (1)
ALSDLELVVQSISFIFAGYETTSSSLSFLTYALATHPEVQEKLQEEIDLAFPNK (0)
APPTYDALLQMDYLDMVLNENLRLFPIAVRLERVCKKNVKINGVFIPKGTVV
MVPNFLLHRDPEFWPEPEEFHPER (2)
FSKKNKDRINPYVYLPFGTGPRNCIAMRFAIMNMKLAVVKLLQNFSFKPCEETQ (0)
IPLKLCNQGLMEPQKPIVLKVEFRDRTVSGP* 420572
CYP3A130P horse
AAWR02045041.1
4 aa diffs to CYP3A93, partial sequence
this seq is on a small contig and it may continue
in the downstream region
7949 MDLIPTFSMETWVLLATSLVLVYL 8020
12115 YGTYTHGLFKKLGIPGPTPLPFFGNVLSYRK 12207
14312 GISNFDRKCFKKYGKMWG 14365
CYP3A131 Felis cattus (cat)
no accession number
Hiroki Teraoka
Submitted to nomenclature committee April 11, 2010
Sequence 1
90% to CYP3A132, 77% to CYP3A4 and CYP3A5 human
90% to CYP3A98 dog
CYP3A132 Felis cattus (cat)
no accession number
Hiroki Teraoka
Submitted to nomenclature committee April 11, 2010
Sequence 2
90% to CYP3A131, 77% to CYP3A4 and CYP3A5 human
90% to CYP3A98 dog
CYP3A133P Callithrix jacchus (marmoset)
chr13:38423087-38424514 (-) strand UCSC Browser
intronless pseudogene
83% to CYP3A4, 79% to CYP3A7, 76% to CYP3A5, 69% to CYP3A43
NUCB2 on left, SAP25 on right (human chr7:100,169,913-100,170,791)
Human CYP3A pseudogene is chr7:99463529-99469880, 700kb away
CYP3A43 is chr7:99425739-99463621
YGTNSHGLFKKLGILGPTPLPFLGTVLSYRQDFWKFDMECYKKYGEVWGIYDGRQPVLAI
ADPNIIKTVLVKECYSVFANRRSFGPVGFMKSAISIATDDKWKKI*SLLSPIFTSGKLKE &
VPIFAQYGEVLVKNLRREAEKGK &
INMKDIFGAYSMDVITDTSFGVNNNSLNNPQDPFVESTKKLLRFDVSDPFFLSITIFPFL
TPILEALNISVFPRDSTSFLRKSIKRIKESRLKDTHKHRVDFLQLMIDSQNSKETESHKA
LSDLELMAQSIIFIFTGYETTSSSLFFVMYELATHPDVQQKPQEEIDAVLPNKAPATYDT
VLQMEYLDMVVNETLRLFPLAMRLERICKKDVEINGMLIPKGVVVMNPSYALHYDPKYWT
ETEKFLPERFSKNNKDNTDST &
YTSFRTGPRNCIGMRFALMNMVLALIRVLQNLSFKPCKEIQIPLKLCLGGLLQTEKPI
VLKVESRDGTVSG
CYP3A134P Macaca mulatta (rhesus monkey)
chr3:46953658-47019448 (-) strand UCSC browser
Pseudogene between 3A7 and 3A4 syntenic with CYP3A7-de1b2b of human
Note: the first exon is 65 kb away from the last three and it may
be an independent pseudogene fragment, but we have kept them together.
LISVSLCRYETHSHGLLKKLRIPGPTPLPFLGTTVSYHQ
APPTYDTVLQMEYLDMVVNETLRLFPVAMRLERVCKKGVEINGMFIPKGVVVMIPT
YVLHHDPKHWTEPEKFLPER (2)
FSKKNKDNIDPYIYTPFGGGPRNCIGMRFALLNMKLALTRVLQNFSFKPCKETQ (0)
IPLKLRFGGIFQPEKPIVLMAESRNGTVSGA
CYP3A135 Ctenopharyngodon idella (grass carp, white amur)
HQ191278.1
92% to CYP3A136 Carassius gibelo
CYP3A136 Carassius gibelo (Prussian carp, wild ancestor of goldfish)
GU998964.1
92% to CYP3A135, 81% to CYP3A126 Pimephales promelas,
78% to CYP3A65 Danio
CYP3A137P human = CYP3A43-de1b (name conflict with carp)
GenEMBL NT_007933.10|Hs7_8090 + strand alternate exon 1
24651143 MDLIPNFAMEMCVLLATSLVLLYL 24651214
CYP3A137 Hypophthalmichthys molotrix (silver carp)
No accession number
Xiao-Yu Li
Submitted to nomenclature committee May 18, 2012
94% to CYP3A135 Ctenopharyngodon idella (grass carp)
92% to CYP3A127 Gobiocypris rarus (a rare minnow)
89% to CYP3A126 Pimephales promelas (fathead minnow)
84% to CYP3A136 Carassius gibelo (Prussian carp)
82% to CYP3A65 zebrafish
CYP3A138 Cyprinus carpio (common carp)
No accession number
Xiao-Yu Li
Submitted to nomenclature committee March 28, 2013
94% to CYP3A136 Carassius gibelo (Prussian carp)
84% to CYP3A137 Hypophthalmichthys molotrix (silver carp)
83% to CYP3A135 Ctenopharyngodon idella (grass carp)
CYP3A-se1[2] human = CYP3A54P
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 2
2460622 LYRYGTCSHGLFKKMAIPGLTLLPF 2460548
CYP3A-se2[5] human = CYP3A55P
NT_033967.1|Hs7_34122 chromosome 7
3A psuedogene Exon 5
2246484 LESGLIITKHEKWKRLRSVISPAFPSGELQEV 2246579
mouse Cyp3a fragments of uncertain location
Cyp3a-se3[1] mouse
NT_039319.1
new 3a frag from 1-24 exon 1 + strand
v in Figure 3B Nelson et al. Pharmacogenetics 14, 1-18 2004.
The true location of this fragment is uncertain
14293 MEPV (frameshift) FSSLTGYEWILLAIILVLLYR 14358
Cyp3a-se4[5:6]X mouse
NT_071157.1|MmUn_71197_30
3a exons 5,6, only 3 aa diffs with 3a63-ps
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
95% to 3a63-ps
549 EFGSVAIMSKAISISKDEECKRYRALLSPTFTSGRLKE 436
356 MFPIIEQYGDILVKYLRQEAEKGKPVAMKD 267
Cyp3a-se5[12]X mouse
NT_071987.1|MmUn_72027_30 3a exon 12
2kb genomic sequence near exon 12 has best match to 3a41a-de12b
The fragment was removed from Genbank
This was probably a poor quality version of 3a41a-de12b
12194 FIKESKGNIHPYIYLPFGNGPRN*IGMRFALLNMKLTLTKVLQNFTFQPCKETQ 12033
Cyp3a-se6[12] mouse
NT_055698.1|MmUn_55738_30 3a exon 12
5 aa diffs with 3a58-ps
identical to 3a11-de9b10b11b12b
may be the same sequence between 3a44 and 3a11
1226 FSMENKGSIDPYX 1191
1186 YLPFGNGPRNCISMRFAVMSMKFALTKLLQNCYFHSCKKTQ 1064
Cyp3a-se7[8:9:10]X mouse
NT_067897.1|MmUn_67937_30 3a exon 8
NT_059425.1|MmUn_59465_30 3a exon 10
5160 bp of the genomic sequence was 98.9% to 3a-se12[8:9:10] pseudogene region
The fragment was removed from Genbank. This was probably a poor quality version of
3a-se12[8:9:10]
5042 FATFFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 4935
4933 IVERTKENCLDSKQK 4889
HQVDFLHLMINAHDNTKDNESHK
979 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLTHHDS*KNLRENDRALPNK 821
Cyp3a-se8[3]X mouse
NT_070793.1|MmUn_70833_30
1 diff to 3a11 exon 3 or 3a63-ps
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
671 GFWKFDMECYKKYGKTWG 618
Cyp3a-se9[8]X mouse
NT_050947.1|MmUn_50987_30
2 diffs to 3a41 exon 9
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
174 HRVDFLQLMMNAHNNSKDKNSHQ 106
Cyp3a-se10[12] mouse
NT_050917.1|MmUn_50957_30
3a exon 12, 3aa diffs to 3a58-ps
521 FSMENKGSIDPYXXXXXX 486
483 NGPRNCISMRFAVMSMKFALTKVLQNFYFHPCKKTQ 377
Cyp3a-se11[2]X mouse
NT_074310.1|MmUn_74350_30 3a exon 12
2 diffs to 3a16, 3a41 3a44, 3a63
whole genomic sequence has best match to 3a63-ps pseudogene
The fragment was removed from Genbank
This was probably a poor quality version of 3a63-ps
1107 YGTLTQGLFKKQGIPGPKPLPFLGTVLNYYK 1199
Cyp3a-se12[8:9:10] mouse
NT_056284.1|MmUn_56324_30
3a exon 10
revised to add two more exons 8 and 9
(+)20506 FICNLFFVPVFFSFLNPI*ETLKISVFPKDSIAFFKK 20616 = Cyp3a-se7[8:9:10]
(+)26737 HQVDFLHLMINAHDNTKDNESHK 26805 = Cyp3a-se7[8:9:10]
(+)31410 MEITTQSIMFIFASYKPISSTLSFGLYSLLT*HDS*KNLQENDEALPNKV 31559 =Cyp3a-se12[10],
4 aa diffs to Cyp3a-se7[8:9:10] exon 10
Cyp3a-se13[9] mouse
Between 3a63-ps and 3a41b in UCSC browser
76087 HQVDFLHLMINAHDKTKDKETHK
identical to exon 9 of Cyp3a44-de9b10b11b and old frag w from map
Cyp3a-se14[8:9:10] 91% to Cyp3a-se12[8:9:10]
(+)24769 FATFFFVPVFFSFLNPI*EMLKISVFPKDSIAFFKK 24876
(+)24878 IVERTKENCLDFKQK 24922
(+)35795 HQVDFLHLMINAHDNTKDNESHK 35863
(+)40413 SMCNMEITTQSIMFIFASYKPTSSTLSFGLYSLLAHHDS*KNLRENDRALPNK 40571
3 aa diffs to Cyp3a-se7[8:9:10]
CYP3A sheep
PIR A60728 (20 amino acids)
Pineau, T., Galtier, P., Bonfils, C., Derancourt, J. and Maurel,P.
Purification of a sheep liver cytochrome P-450 from the
P450IIIA gene subfamily. Its contribution to the
N-dealkylation of veterinary drugs.
Biochem. Pharmacol. 39, 901-909 (1990)
only one amino acid difference with CYP3A24 (L9K)
CYP3A baboon (Papio sp.)
Swiss P80056 (20 amino acids) PIR S21176 (20 amino acids)
Purification of two cytochrome P450 isozymes related to CYP2A
and CYP3A gene families from monkey (baboon, Papio papio)
liver microsomes. Cross reactivity with human forms.
Dalet-Beluche I., Boulenc X., Fabre G., Maurel P., Bonfils C.
Eur. J. Biochem. 204, 641-648 (1992)
3B Subfamily
CYP3B1 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213a
6382 MFEFVLFSGTTWALLALFFALLLL 6311 (2)
6232 YGVWPYHHFKKLGIRGPRPLPFMGSTFYYRK 6134 (0)
6052 GIIPFESWCQAEYGDVWG 5999 (2)
Exon 3 not detected may be in small seq. gap
5469 XFAGPLEDSVSAVKDERWKRIRSTISPCFTSGRLKN 5368 (0)
5259 AFPIVARYADRITKKLEQSNLDEPINVKE 5173 (2)
5069 FLAPYSLDAVTSVSFSVEADSINNPNDPLIVNLKKVFKFNFVVFFLV 4929 (1)
4846 AFFPFCARLFQFLGIDPIPRSSVNYFYNVIKNFKDQHHAD 4727 (bad boundary, 0 expected)
4124 TRGDFLQVLIQSEIPQSEIKSEQDQPPK 4041 (1)
4011 GLTEHEILSQAFIFIFGGYETTTTTLTNVLYGLAINPDVLQVLHKEIDTNIPSD 3850 (0)
3780 APISYEDLMGLQYLDQVLNESQRLYPTAPRLERACKKTVQIHG 3652
3651 LTILEGTIVGIPVHLLHKDPRFWSSPEEFRPER 3553 (2)
3416 FSKDSTEEVNPYAFMPFGLGPRNCVGMRYAILVMKMLIVRLLQSYTVETCKDTM 3252 (0)
3171 IPLEFDWKSQPLKPIKLSFIPRQK* 3097
CYP3B1 Tetraodon nigroviridis (freshwater puffer)
82% to CYP3B1 fugu
MLDLWGLSGTTWTLLALFFALFFL (2)
YGIWPYNHFKKLGIPGPGSLPFIGSLFYYRK (0)
GLVPFERWCQEQYGDIWG (2)
LFSGPLDDGVTVVKDERWKRIRSTMSPCFTSGRLKQ (0)
AFPIVARYADRVTKKLEQSDLDKPIDVKE (2)
FLAPYSLDTVTSASFSVEADAINNPNDPIIVNIKKVLKFNFVVLFLI (1)
AFFPFCSRLLSFLGIDPLPRASVNYFYNLIKKLKDEHHADES (0)
VRGDFLQVLIQSEIPQSEIKSEEDQPPK (1)
GLTEHEILSQAFIFIFGGYETTTTTLTNLLYCLAVNPDALETLHREIDANTSGD (0)
APISYEDLMGLQYLDQVLNEAQRLYPTAPRLERMCKKTVQVQGVTIPEGTVVGIPSHLLHKDPRYWSSPEEFRPER (2)
FSKENAEEVNPYAFVPFGLGPRNCVGMRYALLVMKMVIVRLLQSYTVKTCKDTM (0)
IPLEMDWKYQPLKPIKLSFVPRQK*
CYP3B2 Fugu rubripes (pufferfish)
No accession number
Scaffold_2213b
12175 MFVFMCFSATTWTILVLFSTLLLL (2)
11998 YGHWPYRLFRKNGIPGPMPLPFIGTMWNLLK 11906 (0)
11778 GNMVFDRECQSKYGDVWG 11725 (2)
11412 VFEGRTPVLMVSDPGMIKTILVKECYSVFTNHRVR (0)
11044 IFSGPLETSVFSAKDETWKRMRTSISPCFTSGRLRQ (0)
10847 AFPIIARYADRFIAKLEQTKLEDSTDIKK 10731 (2)
10640 LFGPYSLDVIASSSFSVDADSINNPDDPFIINIKKVLNLNFWLLLIK 10500 (1)
10422 NVLPFSSYLFEFLHIDIIPRSIVDYFFNLIKQLKAQHDQS 10309 (0)
9911 IKGDFLHVMIQNEIPQSEIKSDQDQPPK (1)
8638 GLTEQEILSQSVLFIFGGYDTTTITITYLLYNLAINPDVLQILHSEIDSNFPKD 8483 (0)
8391 TPFSYEDLVGFQYLDQVLNESQRLIPTAPALERFCKKTVQIHGLTIPEGTVVAVPVHLL 8215
8214 HKDPRFWSSPEEFRPER 8164 (2)
XXXXXXXXX in sequence gap
IELGTFMX frameshift
8001 FGLGPRNCIGMRYAILVMKMILVRVLQSYTVETCKDTM 7888 (0)
7808 IPLEFDWKLQPTKQIKLRLVPRQK* 7734
CYP3B2 Tetraodon nigroviridis (freshwater puffer)
73% to CYP3B2 fugu
MPLPFIGTMLYSINK
NLIFDRECQAKYGDVWG (2)
TFEARMPVLMVTNPEMIKTIMVKECYSAFTNHTD (0)
FFSGPLENSVFVAKDEKWKRMRASISPCFSSGRIKQ (0)
AFPIIARYADRFIAKLSQNLEEATDIKQ (2)
LFGPYSLDVVTSSSFSVDADSINNPDDPFILNVKKILQFKFWVLLIK (1)
SMFPFSSYLFKLLGMELTPRPHCGLFYERHQEIQGDFLHVMIQNEIPESQIKSRQDQPSK (1)
GLTEHEILSQSILFIFGGYDTTSVSITNALYNLAINPDALQTLHKEIDTCLPKD (0)
APISYEDLMGLQYLDQVLNESQRLMPTAIRLERVCKKTVQVEGVTIPKGATVVIPLLLLHKDPRFWSSPEEFRPER (2)
FSKEEVNPYAFMPFGLGPRNCVGMRYALLVMKMVIARVLQIYTVETCKDTM (0)
IPMELDWKFQPVKPIKLSLVPRQK*
CYP3B3 Oryzias latipes (medaka)
UCSC Browser, chr15:14900678-14906425, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola1
70% to 3B4, 67% to 3B7, 66% to 3B6, 67% to 3B1
MFFTLLSPTTWTLLALLFALLWLYGTWPHSVFKNLNIPGPKPLPFVGTIFGVRKGLFAFDSECQAKYGDVWGLYDGRSPVLM
VADPEMIKTIMVKECYSVFTNRRETLIPGPFEDGITVVKDDRWKRIRSTISPCFTSGRLKQVFPIVASYADRLLKKLEQTNL
DEPIHVKQFVAPYSLDTVASASFSVEMDSINNSEDPVNVHIQKLFNINFWPFILLMICPFAGRLLNSLNIGMLPKAESDFFL
NIIKKFKDQHKAGESTRQDFLQVMVQSEIPENEIKNEQEQPSKGLTEPEIVAQAFTFILGGYETTSTTLSFILYNLATNPHA
MHTLQKEIDANLQKNASFSYEELNDLHYLDQVILESMRVLPTAPRLERGCKKTVEIQGFTIPEGTVVGIPVMNLHKDPRYWS
SPELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLETCKDTLIPLQFDWKFQPLKPIKLKF
VPRKQ
CYP3B4 Oryzias latipes (medaka)
UCSC Browser, chr15:14910843-14918605, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola2
69% to 3B6, 70% to 3B3, 68% to 3B5, 66% to 3B7, 64% to 3B1
MFWSWFPGATWTLLALLLTILIFYGLWPYRVFKNLGISGPMPLPFVGTVPQQMKGLFAFNRECQAKYGDVWGLYEGRSPLLM
IADPKIIKTVLVKECYSTFTNRRNVFDDDGPLGNGVAAVKDERWKRIRSTISPCFTSGRLKQVFPFVARYADRLVNKLQKMN
LNEPIDIKQFVAPYSLDVVTSASFSVETDCINNPNDPVNVQAIKATNFNLWPMIIRMIFPLGARLLKHFKFEIIPRSSVDFF
CDVIKKIKDQHNAGKLTRPDFLQVMIESEIPESEVKNKKDEPSKGLTEQEILFQAFSFILGGYETTSTTLSHIFYNLAINPD
AMHTLQEEIDANLQKDVPVSYDKLNGLEYLDQVLCESLRLIPPAPLLDRVCKKTMQINGLTIPEGTVVGIPVHLLHRDPRFW
DSPDLFRPDRFSKENEGALNPYAYMPFGLGPRNCVGMRYAILVMKMVIVRLLQNYTLESCKDTLIPIQFNWKFQPLKPIKLK
FVPRKR
CYP3B5 Oryzias latipes (medaka)
UCSC Browser, chr15:14921023-14926010, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola3
71% to 3B6, 68% to 3B4, 66% to 3B3, 62% to 3B7, 59% to 3B1
MLFLFSATTWTLLALIFTILLLFGIWPFRIFQNMGISGPMPMPYVGNLLQQGKGFFEFDHECQTKYGDVWGVFEGRQPILMV
ADPEIIKTVMVKECYSAFTNRRNFFEGDGPLTEAVASAKDEKWKRIRSSLSPCFTSGRLKQVFSIVSRYADRLVEKLGETYL
NKAIDIRQFVAPYTLDVVASASFSVDPDCINNPDDPINVQAQKATRFNFLPTILQSIIPFGGRLLKLFKIETLPSANVEFFI
DIIRNLKDQHKTENRPDFLQVLIESEMPDAEIKNSQQQPSKGLTETEILSQALGFIVGGYDTTSTALSYIFYCLATNTDAMH
TLQKEIDSNLQKNSSISYEDLNGLEYLDQVINESLRLYPVAPRLDRECKMTVETQGFTVPEGMIVGIPVYLLHKDPRFWSSP
ELFRPERFSKENEGELNPYAYMPFGLGPRNCVGMRFAVLMMKMIIVRLLQRYSVETCKYTLIPMQFNWMFQPIKPVKLKFVP
K
CYP3B6 Oryzias latipes (medaka)
UCSC Browser, chr15:14927785-14936321, Apr. 2006 (oryLat1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
ola4
69% to 3B4, 71% to 3B5, 66 to 3B3, 65^ to 3B7, 61% to 3B1
MFSATTWTLLALFFTVLLLYGVWPYRVFRKLGISGPMPLPFVGNVLQMGRDILSFDRQCLDKYGDVWGVFEGRQPMLMVANP
ELVKAVMVKECYSAFTNRRNFFPEDGPLADGVAVVKDEKWKRIRSSLTPCFTSGRLKQVYPLVARYAENLVKKLGRMNSDEP
IDVRQFVAPYSMDVVASTSFSVDTDCINNPDDPVNVQAQKATNFNFWPVILQTMIPFGDLLLKLLKFETLPRSNVDFFYDLI
KRLRDQHKAGKLTRPDFLQVLIDSEIPQEHVKNEQPSKGLTEHEVLSQAFGFVLAGYETMSNTLCFILYNLATNPDAMCTLQ
KEIDSNLQNDGSFSYEELSGLEYLDQVLCESMRFFSPTPRLDRECKKTIEIHGVTIPKGTLVAIPVSLLHMDPRFWSSPEIF
RPERFSKENASELNPYAYMPFGLGPRNCVGMRFAVLVMKMVIVRLLQSYSLETCKDTLIPMQYDWQFQPIKPIKLKFVPRKQ
CYP3B7 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrVI:13967807-13971259, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac49971
68% to 3B1, 66% to 3B4
MFLFDWFPATSWTLLALFFTLLILYGIWPYRFFKNLGIKGPRPLPFIGTFLHFRKGWLSFDRECQAKYGDVWGNFDARLPVL
MVADPEIIKTVMVKECYSVFTNRRENAVPGPMGDAITAVKDERWKRIRTSLSPCFTSGRMKQVFPIVARYADRLTEKLGGMH
SVPIDVKQFMAPYSLDVVTSASFSVEANSINNPDDPLNVHLKNILNFKLWPVFILMVFPFGARLLRLLKLEMLDRVSVDYFY
DVIKHFKHQHGEDESTRADFLQVMIQNEIPDTDIKSEEDQPSKGLTEHEILSQALIFIFGGYETTSTTLTFLLYNLATNPDA
MRTLQEEIDANIPRDAPIRYEDLLGLQYLDQVLLESQRLIPTAPRLERVCKKTTQVHGLTIPKDTLVGIPVQLLHMDPRFWS
SPELFRPERFSKESGEEVNPYAYMPFGLGPRNCVGMRYAVLTMKTVLVRLLQSYNVETCKDTMIPLEFDWKAQPVQPVKLQF
VPREQ
3C Subfamily
CYP3C1 Danio rerio (zebrafish)
GenEMBL BC052130.1 dated 10/7/2003
Also submitted by Don Buhler 10/2/2003
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T,
Chung WG, Buhler DR. CYP3C1, the first member of a new cytochrome
P450 subfamily found in zebrafish (Danio rerio).
Biochem Biophys Res Commun. 2006 Feb 24;340(4):1039-46.
52% to 3A48, 53% to 3B1 fugu, 51% to 3B2 fugu 52% to 3A49
53% to 3A27 trout, 54% to 3A40 Oryzias, 53% to 3A45 trout,
54% to 3A56 fundulus, 54% to 3A30 fundulus, 49% to 3A37 chicken,
48% to 3A29 pig (47% to 50% to many mammal 3As)
3D Subfamily
CYP3D1 Fugu rubripes (pufferfish)
No accession number
Scaffold 600
Formerly CYP3A47, seq revised 6/18/2010
MNYLPLFALETWILLITFTCLFVM (2)
YGKRTFGIFEKLGISGPKPTMYFGSICKYNN (0)
14338 VYYLDQECAQKYGKIWG (2)
14472 TYELRKPMLVVMDPDLLKTILVKECFTHFTNRR (0)
NFCLNGDLYDAVNIAEDDDWRRIRNVLSPLFTTGRIKQ 14879 (0)
IFSLMKRQSSKLTSSLEPKAENEEIISIKD (2)
FFGAYNMNVATGVLFGMEMEPSLPIKHASKLFKFPIPLFMIQ (1)
GCFPILLPLLQLMGFSLFPRDSFAFVKKIVEKIRAERDGGSHQ (0)
EFDFLQHMISTQKNDGIYAVTS
(1) GLTDHEIVSQLTVLLTGGYETSTLALTLSIYSLATNPGSMNRLQEEIDATFPDA (0)
16040 APVTYEALMQMEYVDCVINECLR (2)
LYPPAARLERTAKETVEISGITIPKNMTVTVPIFALHRDPEHWPEPEEFKPDR 16334 (2)
FSKQNKGRINPYTYLPFGIGPRKCLGMRLALVIVKLALVETLQKYSFSVCKETE (0)
IPFKMDPNTFVGPINPIKLRVVRR*
CYP3D1 Tetraodon nigroviridis (freshwater puffer)
chrUn_random:50263388-50265036
first 3 exons and last 2 exons in sequence gaps
68% to CYP3D1 fugu, probable ortholog
MYEFSKPILVVKDPDMLKTILVKECFTHFTNRR (0)
NVGLNGDFYDAVHFAEDDDWRRIRNNVSPFFTTGRIRQ (0)
WFGLMKRQSSRLTSRLQPRAQNEDVVSVKD (2)
FFGPYSINTFTGCLLGVEVDSQLFLKRASNPFKVSIPLFILQ (1)
ACFPVLLPLLKMLGFSVFSGDSFKFVKKVVEKMRADRDGSSHQ (0)
ELDFLQHMTSTQMKAKKDTGNK (1)
GLTDHEIVTQMTVLLAGGHEAVTLVLTLCAYSLATHPQSLRLLQQEVDSTFPDQ (0)
AAVTLEALLQMEYLDGVVSECLR (2)
LYPSNPRLERTAKSTVKISGITIPKDMTVMVPVYALHRDPEHWPQPEEFQPDR (2)
CYP3D1 Large mouth bass
DQ786407
David Barber
Submitted to nomenclature committee 5/21/04
Clone name CYP3A-b
Formerly CYP3A69
64% to CYP3A47 Fugu
note 3A47 was renamed to CYP3D1 so this seq will also be 3D1
MGYLPFLSSETWILLFTFICIFVTYGCWTFGTFEKLGIPGPKPL
MYFGTIGRHNPVYYLADNECAQKYGRVWGMYELRRPMLAVMDPDMLKTILVKECFTYF
TNRRNIRLNGDLYDAVSTVEDDHWKRIRNILSPFFTSGHIKEMFSIMKHHSHKLTASL
QSKVHDDEVITIKDIFGPYSIDVMASCAFSVDMDTINNPSSPLITHASKLFKFSKSLF
LFQGCFPFFLPLLELLGVSFFPKTSTGFFKTVVEKIRAERNKSSQQNSGDVLQHMMNS
QQANEPNKEKQNKGLTDHEITSQATMFVFAGYETSATTLVFLAYNLARNPEVMKHLQE
EIESTFPNKGPVQYEALMQMEYLDSVVHESLRLYPPSPRLERIAKETVKISGITIPKD
MLVMTPVYALHRDPELWPDPEEFKPERFSKQNRQSINPYTYLPFGIGPRNCLGMRFAL
VMIKLALVEVLQNYSFSVCEETEFPLKMDPLSLVGPLQPIKLKLVTR
CYP3D1 Gasterosteus aculeatus (stickleback)
UCSC Browser, chrIX:4874663-4879489, Feb. 2006 (gasAcu1) assembly
Huan Qiu
Submitted to nomenclature committee May 30, 2007
Gac33061
76% to 3D1 bass (ortholog), 61% to 3D1 Fugu,
58% to CYP3A119, 57% to 3A68 bass
MGCLPFFSVETWILLITFICIFVIYGNWTHGIFENLGIPGPKPYTYWGTIGRHNKVYYKDDQQCAEKYGKVWGMYEFRSPML
AVMDPDMLKTILVKQCFTYFTNRRNIRLNGDLYDSVSTVEDDHWRRIRNVLTPSFTSGHIKEMFKIMKHLSSKLTASLQSKA
QNNEVVTIKDYFGAYSVDVMASCAFSVDMDSINNHSSPIIFHASRFFKFPQFVLILQGIFPVLIPLFELLGISFFSPTSTAF
FKTILAKIKAEREGSTHKNSGDFLQSMINSRTANDPSKGEKNKGSLTDHEILTQATMFMVAGYETSATTLAFLAYNLARNPE
VMKRLQEEIDSTFPNKGAVRYEELLQMEYLDSVVNESMRLYPPAGRLDRVAKKTVEIRGITIPKDMIVMIPVYALHRDPDLW
PEPEEFKPDRFSKQNKRSINPYTYLPFGTGPRNCLGMRFALVLVKLALVEVLQNYSFSVCGETEIPLTMDPGGLVGPLNPIK
LKVTTR
CYP3E1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CK326870.1, CF075781
David Drane
3clan 38% CYP3A22 pig
N-term only
MWLAWLIGIVTALS
AYYIIAARRKFEYWQKKGVPGPRPWPLVGVFVQTVRMGQGFYDVWATKQFGRMFGYFDGS
QPVIAVSDPEMLRSIMVKDFPQFINRRDVDINGPLLEQAVSVLHGQKWKDVRSTLVPTFT
SGRLKQMNGLINECCDNLVSNLEKKADADEEFECQSLFRSVTMDVIASTFFG
CYP3F1 Asterina pectinifera starfish
EST DB408526.1 mate = DB394794 (N-term)
C-term part is 51% to CYP3A4 human
N-term part is 39% to CYP3A4 human
MELLGFDLSVTWLLIIGFVLIAVWYDWWCHQYFQ
RRGIPVADYIPFFGNILRWRHGVQTTFTEYVKKHGRVVGMYDFRRPVLIITDPDILKNVL
VKNFSSFYNRRKLPLGQKPLNRGLNQLLNEEWKEIRNVITPSFSASKMRLM
VIAKMEYLDMVINESLRMYPPAVIFDRMCNETITYEGLTIEKGVNVFASLWTLHYDEEFW
PNPTKFDPERFSPENKDSIKPCTYMPFGFGPRNCIGMRFALLEAKMALVRVLQQYRFDVC
SETEIPPKLGKTSFLAPKSMKLSAVPRN*
4A Subfamily
CYP4A1 rat
PIR S21711 (22 amino acids)
Okita, R.T. and Okita, J.R.
Characterization of a cytochrome P450 from Di(2-ethylhexyl)
phthalate-treated rats which hydroxylates fatty acids.
Arch. Biochem. Biophys. 294, 475-481 (1992)
CYP4A1 rat
Aldridge et al.
Biochem. J. 306, 473-479 (1995)
note: identification of far upstream PPAR response element.
CYP4A1 rat
GenEMBL M14972
Hardwick,J.P., Song,B.-J., Huberman,E. and Gonzalez,F.J.
Isolation, complementary DNA sequence, and regulation of rat
hepatic lauric acid omega-hydroxylase (cytochrome P-450-LA-omega):
Identification of a new cytochrome P-450 gene family
J. Biol. Chem. 262, 801-810 (1987)
CYP4A1 rat
GenEMBL X07259
Earnshaw,D., Dale,J.W., Goldfarb,P.S. and Gibson,G.G.
Differential splicing in the 3' non-coding region of rat cytochrome
P-452 (P450 IVA1) mRNA
FEBS Lett. 236 (2), 357-361 (1988)
CYP4A1 rat
GenEMBL M33937 M57718
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A2 rat
GenEMBL M33938 M57719
Kimura,S., Hanioka,N., Matsunaga,E. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A gene subfamily I. Complete
intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique
exon organization, and identification of a conserved 19-bp upstream
element
DNA 8, 503-516 (1989)
CYP4A3 rat
GenEMBL M33936
Kimura,S., Hardwick,J.P., Kozak,C.A. and Gonzalez,F.J.
The rat clofibrate-inducible CYP4A subfamily II. cDNA sequence of
IVA3, mapping of the Cyp4a locus to mouse chromosome 4, and
coordinate and tissue-specific regulation of the CYP4A genes
DNA 8, 517-525 (1989)
CYP4A4 rabbit
GenEMBL L04758 (1378bp) PIR S32315 (510 amino acids)
PIR S32423 (64 amino acids)
Palmer,C.N., Griffin,K.J. and Johnson,E.F.
Rabbit prostaglandin omega-hydroxylase (CYP4A4):
Gene structure and expression.
Arch. Biochem. Biophys. 300, 670-676 (1993)
Note: The translation is different from the 4A4 sequence
in the alignment after AALLG. A frameshift occurs between
nucleotides 1201 and 1203, with an extra "G" added. After 1320
P450 similarity stops. 1320-1378 is an intron sequence.
CYP4A4 rabbit
PIR JN0089 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A4 rabbit
GenEMBL J02818
Matsubara,S., Yamamoto,S., Sogawa,K., Yokotani,N.,
Fujii-Kuriyama,Y., Haniu,M., Shively,J.E., Gotoh,O., Kusunose,E.
and Kusunose,M.
cDNA cloning and inducible expression during pregnancy of the mRNA
for rabbit pulmonary prostaglandin omega-hydroxylase (cytochrome
P-450p-2)
J. Biol. Chem. 262, 13366-13371 (1987)
CYP4A5 rabbit
GenEMBL M28655
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A5 rabbit
GenEMBL X57209
Yokotani,N., Kusunose,E., Sogawa,K., Kawashima,H., Kinosaki,M.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning and expression of the mRNA for cytochrome P-450kd
which shows a fatty acid omega-hydroxylating activity
Eur. J. Biochem. 196 (3), 531-536 (1991)
CYP4A6 rabbit
PIR S23949 (510 amino acids)
Muerhoff, A.S., Griffin, K.J. and Johnson, E.F.
Characterization of a rabbit gene encoding a
clofibrate-inducible fatty acid omega-hydroxylase: CYP4A6.
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A6 rabbit
PIR PQ0047 (20 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
CYP4A6 rabbit
GenEMBL M29531 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A6 rabbit
GenEMBL M28656
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A6 rabbit
GenEMBL L04755
Muerhoff,A.S., Griffin,K.J. and Johnson,E.F.
Characterization of a rabbit gene encoding a clofibrate-inducible
fatty acid omega-hydroxylase: CYP4A6
Arch. Biochem. Biophys. 296, 66-72 (1992)
CYP4A7 rabbit
PIR JN0090 (20 amino acids)
Yoshimura, R., Kusunose, E., Yokotani, N., Yamamoto, S.,
Kubota, I. and Kusunose, M.
Purification and characterization of two forms of fatty acid
omega-hydroxylase cytochrome P-450 from rabbit kidney
cortex microsomes.
J. Biochem. 108, 544-548 (1990)
CYP4A7 rabbit
GenEMBL M29530 J05150
Yokotani,N., Bernhardt,R., Sogawa,K., Kusunose,E., Gotoh,O.,
Kusunose,M. and Fujii-Kuriyama,Y.
Two forms of omega-hydroxylase toward prostaglandin A and laurate:
cDNA cloning and their expression
J. Biol. Chem. 264, 21665-21669 (1989)
CYP4A7 rabbit
GenEMBL M28657
Johnson,E.F., Walker,D.L., Griffin,K.J., Clark,J.E., Okita,R.T.,
Muerhoff,A.S. and Masters,B.S.
Cloning and expression of three rabbit kidney cDNAs encoding lauric
acid omega-hydroxylases
Biochemistry 29, 873-879 (1990)
CYP4A8 rat
PIR S08300 (15 amino acids)
Imaoka, S., Nagashima, K. and Funae, Y.
Characterization of three cytochrome P450s purified from
renal microsomes of untreated male rats and comparison with
human renal cytochrome P450.
Arch. Biochem. Biophys. 276, 473-480 (1990)
CYP4A8v1 rat
GenEMBL M37828
Stromstedt,M., Hayashi,S., Zaphiropoulos,P.G. and Gustafsson,J.A.
Cloning and characterization of a novel member of the cytochrome
P450 subfamily IVA in rat prostate
DNA Cell Biol. 9 (8), 569-577 (1990)
CYP4A8v2 rat
UCSC browser
This is the best match to M37828, but there are some differences
especially in exon 6 (9aa diffs)
97% TO 4A8v1 M37828 chr5:135553023-135583411 (- strand) BC081771
CK483390.1 AGENCOURT EST matches
135583411 MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHK 135583223 (0)
135581811 IPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRS 135581671 (1)
135581054 DPKSHHSYRFLAPWI 135581010 (1)
135580577 GYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIML 135580449 (0)
135558913 DKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDR 135558788 (2)
135558475 KYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHT 135558323 (1)
135557899 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135557792 (0)
135557703 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135557512 (2)
135557411 DDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPK 135557280 (1)
135556361 GITVMLSFYGLHHNPTVWPNPE 135556296 (0)
135556143 VFDPYRFAPESSRHSHSFLPFSGGAR 135556066 (2)
135553187 NCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ 135553023
CYP4A8v2-de1b rat
UCSC browser
CYP4A exon 1 pseudogene chr5:135545150-135545338 (- strand)
Frag a in fig. below
135545338 MSIFELSHITTGFGISGLLQMVSWLGLLLLLLFKAAQYYLHRQWIIKSVQHFPSPPSHWFFGN 135545150
human, mouse and rat 4ABXZ clusters
CYP4A8v2-de5c6c12c rat
UCSC browser (upper line is the new sequence)
135596695-135596537 (- strand) C exon 5
Frag b in fig. below
Query: 37481 SVLLPQNKWE*TISDS---LEIFQCASLITLATILMCVFSY*DNVHLNRSVTSQSF 37639
SV + +KWE + D LEIF SL+TL T++ C FS+ +V L+ V S+S+
Sbjct: 159 SVSIMLDKWE-KLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 211
135596212-135596066 (- strand) D exon 6
Query: 37964 HSQTYTQVVGILNNL-----RNAFPQSDIFYRMTADGHRTKNAFLIAHKHSDFV 38110
+S++YT+ V LNNL R+AF + I Y M++DG ++ A IAH+H+D V
Sbjct: 207 NSRSYTKAVEDLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTDGV 260
135594009-135593884 (- strand) E exon 12
Query: 40167 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 40292
KQF MNE+KV + LTLL FE L DPTR+ V + +L + G
Sbjct: 454 KQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNG 495
human, mouse and rat 4ABXZ clusters
CYP4A8v2-de4d12d rat
UCSC browser (upper line is the new sequence)
135628319-135628215 (- strand) A exon 4
51% to 4A8
Frag c in fig. below
Query: 5857 LSNDQTWFQHY*HI*TPLLHCDILKSNVRIVADCI 5961
L N + WFQH + TP H DILK V+I+AD +
Sbjct: 127 LLNGKKWFQHR-RMLTPAFHYDILKPYVKIMADSV 160
135617441-135617274 (- strand) B exon 12
75% to 4A2 76% to 4A8
Query: 16735 RICIGKQLAMNAQKLAVALTLLQFELLPDPTRVPIPTEKLVLKSKNGIHLHLRKLQ 16902
R CIGKQ AMN K+AVALTLL+FELLPDPTR+P+P +LVLKSKNGIHL L+KL+
Sbjct: 449 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRLKKLR 504
human, mouse and rat 4ABXZ clusters
Cyp4a10 mouse
GenEMBL X69296 (1887bp)
Colin J. Henderson, Theo Bammler & C. Roland Wolf
Deduced amino acid sequence of a murine cytochrome P-450 Cyp4a
protein: developmental and hormonal regulation in liver and kidney
Biochim. Biophys. Acta (1994) 1200, 182-190
Cyp4a10 mouse
GenEMBL X71478 (129bp) PIR S35608 (43 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
GenEMBL Y10221 (exons 10-12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a10 mouse
GenEMBL AB018421
Yasumura,N. and Ikeda,T.
Polymorphism of cyp 4A10 sequence between C57BL/6 and ddY mouse
Unpublished (1998)
Cyp4a10 mouse
GenEMBL NT_039264.1 + strand
15663999 MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRQWLLKAFQQFPSPPFHWFFGHE 15664187
15665307 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS 15665450
15665928 DPKANGAYRLLAPWI 15665972
15666744 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLML 15666872
15669925 DKWERLADQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVD 15670047
15670403 NYRTYLQAIGDLNNLFHSRVRNIFHQNDTIYKLSSNGRLAKQACQLAHDHT 15670555
15670978 DGVIKLRKDQLQDEGELEKIKKKRRLDFLDILLFAR 15671085
15671175 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPDHQQRCREEVQSLLGDGSSITW 15671366
15671463 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPK 15671594
15674911 GVQVTLSIYGLHHNPKVWPNPE 15674976
15675119 VFDPSRFAPDSPRHSHSFLPFSGGA 15675193
15678206 RNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMPLARLVLKSKNGIYLHLKKLH* 15678376
CYP4A11 human
GenEMBL L04751 (2576bp)
PIR S29845 (519 amino acids)
Palmer,C.N., Richardson,T.H., Griffin,K.J., Hsu,M.-H.,
Muerhoff,A.S., Clark,J.E. and Johnson,E.F.
Characterization of a cDNA encoding a human kidney,
cytochome P450 4A fatty acid omega-hydroxylase and the
cognate enzyme expressed in Escherichia coli.
Biochim. Biophys. Acta 1172, 161-166 (1993)
CYP4A11 human
GenEMBL X71480 (423bp) PIR S35609 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
CYP4A11 human
GenEMBL S67580 (2470bp) and S67581 (2469bp)
Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
Complete cDNA sequence and cDNA-directed expression of
CYP4A11, a fatty acid omega-hydroxylase expressed in human
kidney.
DNA Cell Biol. 12, 893-899 (1993)
GenEMBL NM_000778
Imaoka,S., Ogawa,H., Kimura,S. and Gonzalez,F.J.
Complete cDNA sequence and cDNA-directed expression of CYP4A11, a
fatty acid omega-hydroxylase expressed in human kidney
DNA Cell Biol. 12, 893-899 (1993)
CYP4A11 human
GenEMBL D26481 (2382bp) PIR JX0331, PC2194 (519 amino acids)
Kawashima,H., Kusunose,E., Kikuta,Y., Kinoshita,H., Tanaka,S.,
Yamamoto,S., Kishimoto,T. and Kusunose,M.
Purification and cDNA cloning of human liver CYP4A fatty acid
omega hydroxylase.
J. Biochem. 116, 74-80 (1994)
CYP4A11 human kidney
GenEMBL D13705 (1809bp)
Kikuta,Y.
unpublished (1994)
P-450 HVK, fatty acid omega hydroxylase
CYP4A11 Pan troglodytes (chimp)
missing some internal seq. and the N-term
DQ037004.1
MKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMAD SVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDL NNLVFXXXRNAFXXNDTIYSLTSAXXWTHRACQLAHXXXXXXXXXXXXXXXXXXXXXXXX XXXXXXXXXXXXXXXMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQ ERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALXXYPXXPGXXXXXXXXXXXXXXXX XXXXIMVFLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPFSGGSXXXXXXXXAM NELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL
CYP4A11 Macaca fasicularis (cynomolgus monkey)
DQ074797
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4A11_24C2
95% to CYP4A11 human 92% to 4A22
MSVSVLSPSRLLGSVSGILQVTSLLILLLLLIKAAQLYLHRQWL
LKALQQFPCPPSHWFFGHFQKFQQDQELQRIRKWVEMFPSACPLWLWGGKVRVQLHDP
DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVA
LMADSVRVMLDKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRDSQSYI
QAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHTDQVIQLRKAQLQK
EGELEKVKRKKHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL
YALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGISRE
LSTPVTFPDGRSLPKGIAVMLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF
SGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRR
LPNPCEDKDQL
CYP4A11 Macaca mulatta (rhesus monkey)
94% to human 4A11
MSVSVLSPSRLLGGVSGILQVASLLILLLLLIKAAQLYLHRQWLLKAFQQFPCSPSHWLFGHKQE (0)
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS (1)
DPKSQDPYRFLAPWI (1)
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML (0)
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR (2)
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT (1)
DQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK (0)
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW (2)
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK (1)
GITVMLSIYGLHHNPKVWPNPE (0)
VFDPSRFAPGSAQHSHAFLPFSGGSR (2)
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL
Cyp4a12a mouse
no accession number
Jorge Capdevila
submitted to nomenclature committee 12/4/96 fax
complete sequence 4aVJ2
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
MKLILGRSDPKANGSYRFLAPWIGRGLLMLDGQTWFQHRRMLTPAFHYDILKPYTEIM
ADSVRVMLDKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
VEDLNDLVFSRVRNIFHLNDIIYRVSSNGCKANSACKLAHDHTDQVIKSRRIQLQDEE
ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
LATNPEHQQRCRKEIQSLLGDGTSITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKELQ
Cyp4a12a mouse
GenEMBL Y10222 (exon 12)
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Chromosomal assignment of this gene is given.
Cyp4a12a mouse
GenEMBL X71479, Y10222 EST AA882070 vx36a01.r1 no UNIGENE entry
NT_039264.1
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWLLSSTQQFPSPPSHWLFGHK
ILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDYMKLILGRS
DPKANGSYRFLAPWIG
RGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIMADSVRVML
DKWEQIVGQDSTLEIFRHITLMTLDTIMKCAFSHEGSVQLDRK
YKSYIQAVEDLNDLVFSRVRNIFH(Q)NDIIYRVSSNGCKANSACKLAHDHT
DQVIKSRRIQLQDEEELEKLKKKRRLDFLDILLFAR
MENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQRCRKEIQSLLGDGTSITW
NDLDKMPYTTMCIKEALRIYPPVPSVSRELSSPVTFPDGRSLPKG
IHVMLSFYGLHHNPTVWPNPE
VFDPSRFAPGSSRHSHSFLPFSGGA
RNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ*
Cyp4a12a-de5b mouse
GenEMBL NT_039264.1 + strand, exon 5
x in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15432755 NKWE*NISDSLEIFQCASLITLATIIMCAFSYQDNVHLNRSVTYIKWVRKL 15432907
cyp4a12b mouse
GenEMBL X71479 (423bp) PIR S35610 (141 amino acids) NM_172306
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
PCR fragment
NM_172306 97% identical to Cyp4a12a 11 diffs
MSASALSSIRFPGSISEYLQVASVLSLLLLLFKTAQLYLHRQWL
LSSTQQFPSPPSHWLFGHKILKDQDLQDILTRIKNFPSACPQWLWGSKVRIQVYDPDY
MKLILGRSDPKAHGSYRFLAPWIGRGLLLLDGQTWFQHRRMLTPAFHYDILKPYTEIM
ADSVRVMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSHEGSVQLDRKYKSYIQA
VEDLNNLFFLRVRNIFHQNDIIYRVSSNGCLANSACQLAHDHTDQVIKSRRSQLQDEE
ELEKLKKKRRLDFLDILLFARMENGKSLSDKDLRAEVDTFMFEGHDTTASGISWIFYA
LATNPEHQQRCRKEIQSLLGDGASITWNDLDKMPYTTMCIKEALRIYPPVPSVSRELS
SPVTFPDGRSLPKGIHVMLSFYGLHHNPTVWPNPEVFDPSRFAPGSSRHSHSFLPFSG
GARNCIGKQFAMNELKVAVALTLLRFELLPDPTRVPIPIPRIVLKSKNGIHLHLKKLQ
Cyp4a12b-de2b5b mouse
GenEMBL NT_039264.1 + strand
exons 2,5
w in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15541025 LLVYDPD*VTLILGRA 15541072
15544976 NKWE*NISDSLEIFQCASLITLATIIMCAFSYQDNVHLNRSVTYIKWVRKL 15545128
CYP4A13 Cavia cobaya (guinea pig)
GenEMBL X71481 (423bp)
PIR S32714 (141 amino acids) PIR S35611 (141 amino acids)
Bell,D.R., Plant,N.J., Rider,C.G., Na,L., Brown,S., Ateitalla,I.,
Acharya,S.K., Davies,M.H., Elias,E.E., Jenkins,N.A.,
Gilbert,D.J., Copeland,N.G. and Elcombe,C.R.
Species-specific induction of cytochrome P-450 4A RNAs: PCR
cloning of partial guinea-pig, human and mouse cDNAs.
Biochem. J. 294, 173-180 (1993)
Cyp4a14 mouse
GenEMBL Y11639 to Y11642 exons 1-12
Heng,Y.M., Kuo,C.W.S., Jones,P.S., Savory,R., Shultz,R.M.,
Tomlinson,S.R., Gray,T.J.B. and Bell,D.R.
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a
and Cyp4b, but not of CYP4F, genes in mouse and humans.
Biochem. J. 325, 741-749 (1997)
Cyp4a14 mouse
no accession number
Jorge Capdevila
submitted to nomenclature committee
complete sequence
Cyp4a14 mouse
GenEMBL NT_039264.1 - strand also Y11638 NM_007822
15641790 MGFFLFSPTRYLDGISGFFQWAFLLSLFLVLFKAVQFYLRRQWLLKTLQHFPCMPSHWLWGH 15641605
15640707 LFPKDKELQQILIWVEKFPSACLQCLSGSNIRVLLYDPDYVKVVLGRS 15640564
15639891 DPKASGIYQFFAPWI 15639847
15639380 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVKIMADSVNIML 15639252
15638411 DKWEKLDGQDHPLEIFHCVSLMTLDTVMKCAFSYQGSVQLD 15638289
15637911 NSKLYTKAVEDLNNLTFFRLRNAFYKYNIIYNMSSDGRLSHHACQIAHEHT 15637759
15637345 DGVIKMRKSQLQNEEELQKARKKRHLDFLDILLFAR 15637238
15637154 MEDRNSLSDEDLRAEVDTFMFEGHDTTASGISWIFYALATHPEHQQRCREEVQSILGDGTSVT 15636966
15636875 DHLGQMPYTTMCIKEALRLYPPVISVSRELSSPVTFPDGRSIPK 15636744
15635704 GITATISIYGLHHNPRFWPNK 15635639
15635542 VFDPSRFAPDSSHHSHAYLPFSGGS 15635468
15632990 RNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPVPIARLVLKSKNGIHLCLKKLR* 15632820
CYP4A15 Phascolarctos cinereus (koala)
AF463456
Ieva Stupans
Submitted to nomenclature committee Oct. 20, 1999
69% identical to human 4A11
MNSPLSFAWFQGNVSGLLQVSFLLGLGLLVLKVAQMYVRRQRLL
RDFQNFPGPPSHWLYGNTLEFPVEEELPKMASLAEKFPCAFPRWLTGSWNLLQVYDPE
YMKLILSKRDPKSHDVYKFLIPWIGKGLLVLNGSDWFRHRRLLTPAFHSDILKPYVGL
MADSARVMLDKWEKLSYQPLSLEISEHVSLMTLDSLMKCAFSHQSNCQMDRHSNLYIQ
AVHDLSYLLSSRMRNAFYHNDVLYWFSSAGRRTREAAQRAHQYTDQVIQRRRQQLEQE
GGLEAISRKRHLDFLDILLCARTEGGDSLLDEELRAEVDTFMFEGHDTTASGISWLLY
ALATHPEHQQKCREEIRGVLGDGTSITWDHLGQLPYTTMCIKEALRLYPPVPSIGRDI
KETITFPDGRILRAGNSVSLHIYALHHNPRVWENPEVFNPFRFSPENLTLQHSHAFLP
FSAGSRNCIGQKFAMNEMKVVLALTLLLFELKPDTMKPPLPISKLVLKSK
CYP4A16 Felis cattus (domestic cat)
GenEMBL U91787
Gebremedhin,D.G., Lange,A.R., Narayanan,J., Aebly,M., Jacobs,E. and
Harder,D.R.
Cerebral vascular smooth muscle cells express cytochrome P450 4A2
enzyme and produces 20-HETE which enhances L-type calcium current
Unpublished
CYP4A17 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4ai 90% to mouse Cyp4a10 95% to 4A19
CYP4A18 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4aii 88% to rat CYP4A1 88% to 4A19
CYP4A19 hamster
No accession number
David Bell
Submitted to nomenclature committee 12/1/99
170 amino acid C-terminal fragment from I-helix to heme
Clone name 4aiii 92% to rat CYP4A1 95% to 4A17
CYP4A20X human
GenEMBL AJ131016 AC026935 161971-176942
Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
Full length seq now available on genomic DNA
52% to 4A11 52% to 4X1
because the sequence is the same percent identity to
4A11 and 4X1 and this is less than 55%
and the sequence does not cluster with CYP4As on a tree
the earlier name of CYP4Z1 is being resurrected.
This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDRS
SYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
HLEKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV
CYP4A21 pig
GenEMBL AJ278474
Lundell K, Hansson R, Wikvall K.
Cloning and expression of a pig liver taurochenodeoxycholic acid
6 alpha-hydroxylase (CYP4A21): a novel member of the CYP4A subfamily.
J Biol Chem. 276, 9606-12 (2001)
77% to rabbit 4A6
submitted to nomenclature committee July 3, 2000
This enzyme catalyzes a 6alpha-hydroxylation of chenodeoxycholic acid
CYP4A21 pig
NM_214425, AJ586859
MTVPALASVSGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSEPKAPVLYRLLIPWIGCGLLLLNGQMWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSQSYIQAIWDL
KNLIFSRLRSAFLQNDIIYRLSPEGRQCQRACQKVHQHTDRVIQLRKTHLQKEGEMEN
VKKKRHLDFLDILLFARMENGNSLSDTDVRAEVDTFMAAGHDSTASGISWVLYALASN
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPSVGRELSKPIT
FPDGRSLPAGIILSLSIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVVVALTLLRFELAPDPSRIPVPIQGIVLKSKNGIHLNLRKIP
CYP4A22 human
GenEMBL AL390073.5, AF208532 AL135960 all genomic sequences
new 4A11 like genomic sequence 95% identical to 4A11
three different gene sequences agree
so this gene is different from 4A11
MSVSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQE
FQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRS
DPKSHGSYKFLAPRI
GYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVML
DKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQVDR
NSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHT
DQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKG
IMVLLSIYGLHHNPKVWPNLE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL*
Also AF208532
Homo sapiens fatty acid omega-hydroxylase CYP4A11 like gene, complete cds
CDS join(2564..2758,5858..5999,6649..6693,7186..7313,
8347..8471,8840..8994,9435..9541,9628..9818,9915..10048,
10944..11008,11155..11231,13680..13875)
also AL135960 matches new 4A gene not 4A11 gene
Human DNA sequence from clone RP1-18D14 on chromosome 1 Contains genes for SIL (TAL1
(SCL) interrupting locus ), TAL1 (T-cell acute lymphocytic leukemia 1), 17 KD membrane associated protein (DD96 protein), CYP4A11 -like gene
gi|6635875|emb|AL135960.1|AL135960[6635875]
CDS complement(join(129154..129349,131798..131874,
132021..132085,132981..133147,133211..133401,
133488..133594,134035..134189,134558..134682,
135716..135843,136336..136380,137030..137171,
140271..140465))
CYP4A22 Pan troglodytes (chimpanzee)
XM_513388.3
98% to human
MSVSVLSPSRLLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWL LKALQQFPCPPSHWLFGHIQEFQHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDP DYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVG LMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYI QAISDLNSLVFCRMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQK EGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWIL YALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRE LSTPVTFPDGRSLPKGIMVFLSIYGLHHNPKVWPNPEVFDPSRFAPGSAQHSHAFLPF SGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRR
LPNPCEDKDQL
CYP4A22 Macaca mulatta (rhesus monkey)
AC203029.4
ortholog (first two exons then a seq gap in genome assembly)
AC203029.4 has all of it with a perfect match to the first two exons.
97% to 4A11 rhesus, 94% to human 4A11, 92% to human 4A22
syntenic with 4A22 human
MSVSVLSPSRLLGSVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWFFGHFQK
FQQDQELQRIRKWVEMFPSACPLWLWGGKARVQLHDPDYMKVILGRS
SDPKSHGSYRFLAPWIG
GYGLLLLNGQTWFQHRRMLTPAFHYDILKAYVALMADSVRVML
DKWEKLLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDR
DSQSYIQAISDLNNLVFSRVRNVFHQNDTIYSLTSTGRWTHRACQLAHQHT
TDQVIQLRKAQLQKEGELEKVKRKKHLDFLDILLLAK
MENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDGASITW
NHLDQMPYTTMCIKEALRLYPPVPGISRELSTPVTFPDGRSLPK
GITVMLSIYGLHHNPKVWPNPE
VFDPSRFAPGSAQHSHAFLPFSGGSR
NCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLPNPCEDKDQL
CYP4A23 pig
GenEMBL AF384031
Van Es,A., Calleja,C. and Galtier,P.
Cloning of a new member of the cyp4a subfamily in the pig renal
cell line LLC-PK1
Unpublished
Note: CYP4A23, 24 and 25 are all on the border of being alleles of the same gene
CYP4A23 pig
NM_214424.1
MTVPALASVSGPLQVASLLGLLLLLLKAAQLYLHRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELPPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSDPKTSVVYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSVQTDGDSHSYIQAIWDL
KNLFSTRTKSAFLQNDIIYRLSPEGHKNHRAARIAHQHTDRVIQLRKAQLQKQGEMEN
VRKKRHLDFLDILLLAQMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASH
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPIT
FPDGRSLPAGIILSLFIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVAVALTLLRFELAPDPSRKPIATPEVVLNSKNGIHLKLRKLP
CYP4A24 pig
GenEMBL AJ318096
Kerstin Lundell
97% to pig 4A25, 97% to pig 4A23 AF384031, 90% to pig 4A21 AJ278474
77% to rabbit 4A6, 75% to human 4A11
submitted to nomenclature committee June 12, 2001
Note: CYP4A23, 24 and 25 are all on the border of being
alleles of the same gene
CYP4A24 pig
AJ586619, NM_214424
MTVPALASASGLLQVASLLGLLLLLLKAAQLYLHRQWLLKALQQFPSPPSHWLYGHSREFQEESELPPLLKRVEKYPSACALWRWGTRAMVLVYDPDYMKVVLARSDPKNSVVYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSVQVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDLKNLFSIRTKSAFLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMENVRKKRHLDFLDILLLARMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPITFPDGRSLPAGITLSLSIYGLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRNCIGKQFAMNEMKVAVALTLLRFELAPD
CYP4A25 pig
GenEMBL AJ318097
Kerstin Lundell
97% to pig 4A24, 96% to pig 4A23, 91% to pig 4A21, 78 % to rabbit 4a6,
75% to human 4A11
submitted to nomenclature committee June 12, 2001
Note: CYP4A23, 24 and 25 are all on the border of being
alleles of the same gene
MTVPALASASGLLQVASLLGLLLLLLKAAQLYLRRQWLLKALQQ
FPSPPSHWLYGHSREFQEESELQPLLKRVEKYPSACARWLWGTRAMVLVYDPDYMKVV
LARSEPKAPVLYRLLIPWIGCGLLLLNGQTWFQRRRMLTPAFHYDILKPYVGLMAKSV
QVMLDKWEQLVAQDPRLEIVGPVSLMTLDTIMKCAFSHQGSAQTDGDSHSYIQAIWDL
KNLFSIRTKSAFLQNDIIYRLSPEGRKNHRAARIAHQHTDRVIQLRKAQLQKQGEMEN
VRKKRHLDFLDILLLARMEKGNSLSDTDLRAEVDTFMFEGHDTTASGISWILYALASH
PEHQQRCREEIQGLLGDGTSITWDHLDQMPYTTMCIKEALRLYPPVPGVSRELSKPIT
FPDGRSLPAGIILSLSVYSLHHNPQVWPNPEEFDPSRFAPGSARHSHAFMPFSGGSRN
CIGKQFAMNEMKVAVALTLLRFELAPDPSRKPTVIPEVVLHSKNGIHLKLRKLP
CYP4A26P human = CYP4A-se1[12]
AL731892.5
76% to 4A11 C-term upstream of 4A11
TCIGKKFAMNEL 135092
135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
NT_04852.13 - strand
7968299 TCIGKKFAMNELKVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRVPNHCGDKDQL* 7968105
CYP4A27P human = CYP4A-se3[12]
AL731892.5
67% to 4A11 C-term
168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
NT_04852.13 - strand exon 12
8001510 NCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRLPNTCEDKNQI* 8001322
Cyp4a28p mouse
AJ297131 also on NT_039264.1, NT_039685.1
lower case = 4a10, same contig as 4x1
4.112000001-113000000 from Ensembl mouse version 3 chr 4 add 112 million to numbers
943832 MSISALSPTRFLECVSGFLQVVSLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 943647
939707 QFKEDEELRWVLRYVEKFPSAFLHWIWGN 939621 frameshift
939621 *VFIKIYDPDYMKVILGRA 939565
939009 SDPKAGLYRFLTPWL 938965
938111 GHGLFILNGHKWFQHRRMLTSAFHYDILKPYVGTMADSVQVIL 937983
930960 DKWEQIACQDITLEIFHPISLMMLETIMKCAFSYQGSVQLDRS 930832
930514 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 930359
929925 DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 929809
DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 929542
EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 929424
(missing exon 10)
927997 VFDPSRFAMNSVQHSHAFLPFSGGS 927923
926387 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHL 926238
exact duplicate of exons 6-12
925899 RSSQAYLQAVSDLNNLVTSRMTNVFLHNDIIYNLTSHSRRTNSACQIAHEHT
DRVVKLRKAQLQDNKSMEKLRGKRCLDFLDILLLSRVSS 925195
DDGSSLSDKALRAEVDSLMFGDHDTPASGISWVFYALATHPNHQQRCTEEVQSLLGDGSPITW 924927
EHLHQMPYTTLCVKEAQRLYPTVPSVGRKLNTPVTFPDGRSLPKG 924809
923831 IESTVSCFIFSSAWKAFDKPE
923372 VFDPSRFAMNSVQHSHAFLPFSGGS 923298
922002 RNCIGKQLAMNALKVAVALTLLRFELLPDPT*VPIPTHQLILKSTNGIHLHLRKL 921838
Cyp4a29 mouse
4.113000001-114000000 chr 4 from mouse Ensembl version 3 add 113 million to numbers
91% to 4A28p
47095 MSISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGH 47280
53123 QFKVDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRA 53266
53824 SDPKASLYRFLTPWL 53868
54675 GHGLFFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVML 54803
55849 EKWEQIACQDITLEIFHPISLMMLDTIMKYAFSYQGSVQLDRS 55977
56295 RSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHEHT 56450
56880 DRVVKLRKAQLQDNKSMKKLRGKRCLDFLDILLLSRVSS 56996
57075 DDGSSLSDKALRAEVDSLMFGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITW 57263
57362 DHLHQMPYTTMCIKEALRLYPPIPSVGRKLSTPVTFPDGRSLPKG 57378
58567 IESTVSCFIFFSAWKAFDKPE
59045 VFDPSRFAMNSVQHSHAFLPFSGGS 59119
60585 RNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHLRKL 60749
Cyp4a29-de5b6b7b9b mouse
GenEMBL NT_039264.1 + strand
old temp name = Cyp4azzp
y in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15364293 QWEKII**DTTLEIFHHVSLMMLNTIIKCAFCYQGSVPLDRS 15364418
15364782 RNFQSYLQAVSYLNSIKSFCMLNLFQQNSYKLSSDGHRANCACQTVRKY 15364928
15365362 TD*VIKMRKAQQSKGSMEKLRGKR 15365433
15365704 FVGSSLLRNCIEKQLAMNVLKMDAALTLLGFD 15365799
Cyp4a29-de12b mouse
GenEMBL NT_039264.1 Cyp4axxp + strand
78% to 4a29
old temp name = Cyp4axxp
z in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15321475 KNCIVKQIAMNTLKVAVALTLLQFERLPDPTRVPIPTLQLVLI 15321603
15322479 SKNAIHLHLRKLQ* 15322520
Cyp4a30a-ps mouse
GenEMBL NT_039264.1 + strand
old temp name = Cyp4aaab
missing exons 1-4
15489465 DKWEQLVGQDCPLEIYQDISLMTMETIMKCAFSYQGSVQLE 15489587
15489953 NSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHT 15490105
15497986 ERVICMRKAQLQNEAELEKVRKKKHLDFLDILLFAQ 15498093
15498179 TEDGKSLSDEDVRAEVDTFRFEGHDTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVTW 15498370
15498472 NYLDQMPYTTMCIKEALRLYPPIPGVSREFSSPVTFPDRRSLPK 15498603
15500524 GFLVTLSFYGLHHNPRLWPNAE 15500589
15500709 VFDPSRFAPGAPWHTHAFLPFSAGTR 15500786
15508625 RNCIGKQFTMNELKVAVALTLLRFELLPDPTSVPILVLRIVLKSKNGIYLHIKKL 15508789
Cyp4a30b mouse
NT_039264.1 + strand 94% to Cyp4a30a-ps
old temp name = Cyp4aaa, also old 4ayy frags belong to this gene
LOC230640 from mouse genome
68% to 4a10
1 MSIFELSHITNVFGIFGLLQVVSLLGLLLLLLKSAQYYLHRQWLIKSLQQFPPAPPPQWLFGN 189
1729 XFPKDQDLQQILLCVEKFPSTYVRWLWGNHARVVIYDPDYMKVILGRS 1869
2385 DPKVVRSYSFFAPWI 2429
4002 GYGLLLLNGKKWFQHRRMLTPAFHYDILKPYVGIMVDSVHVML 4130
5130 DKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSVQLE 5252
5617 NSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSS 5721
5723 NGRSFYHACQIAHKHT 5770
6175 ERVIRMRKAQLQNEAELEKFRKKKRLDFLDILLFAQ 6288
6374 TEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIFYALATHPEHQQRCREEVKSILGNGTSVT 6562
6666 NHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTFPDGCSLPK 6797
8724 GFLVTLSFYGLHHNPRLRPNAE 8789
8903 VFDPSRFAPGAPRQTHAFLPFSAGTR 8986
18305 NCIGKQFTMNELKVAVALTLLRFELLPDPTRVPILVSKIVLKSKNGIYLHTKKL 18472
Cyp4a31 mouse
GenEMBL NT_039264.1 + strand
old temp name = Cyp4abb
15709394 MSVSALSLTRFAGSLSGFLQVASVFCLLLLLVKAVQVYLHRKWLLKALQQFPSPPFHWFFGHE 15709582
15710687 QFKGDQELQEIVSCIENFPSAFPRWFWGSKAYLTVYDPDYMKVILGRS 15710830
15711347 DPKANGAYRLLAPWI 15711391
15712156 GYGLLLLNGQSWFQHRKMLTPAFHYDILKTYVKNMADSIRLML 15712284
15715386 DKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDx 15715508 (g)
15715864 NYKTYLQAIGDLNNLVHSRVRNMFHQNDTIYKLSSNGRLSNQACQLAHDHT 15716016
15716439 DGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFAR 15716546
15716635 MENEDSMSDKDLRAEVDTFMIEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITX 15716823
15716923 DHLDQIPYTTMCIKEALRLYPPVPSIGRELSTSVTFPDGCSLPK 15717054
15720376 GVQVTLSIYGLHHNPKVWPNPE 15720441
15720567 VFDPSRFAPDSPRHSHSFLPFSGGA 15720641
15723611 RNCIGKQFAMSELKVIVALTLLRFELLPDPTRVPMSLARFVLKSKNGIYLHLKKVH* 15723781
Cyp4a32 mouse
GenEMBL NT_039264.1 + strand
15746652 MSVSALSPTRFADSLSGFLQVASVLGLLLLLVKAVQFYLHRKWLLKALQQFPSPPFHWFFGHE 15746840
15747937 QFKGEQELKEVVSCIEHFPSAFPCWFWGSNAYLTVYDPDYMKVILGRS 15748080
15748604 DPKANGIYRLLAPWI 15748648
15752321 GYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLML 15752449
15755304 DKWERLAGQDSSIEIFQHISLMTLDTVMKCAFSHKGSVQVDX 15755426
15756131 NYKTYLQAIGDLNNLFHSRVRNIFHQNDTIYRLSSNGRLAKQACQLAHDHT 15756283
15756698 DGVIKMRKDQLQDEGELENIKKKRRLDFLDILLFAR 15756805
15756894 MENGDSMSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSLLGDGSSITW 15757085
15757182 DHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPK 15757313
15760289 GVQVTLSIYGLHHNPKVWPNPE 15760354
15760497 VFDPSRFAPDSPRHSHSFLPFSGGA 15760571
15767109 RNCIGKQFAMSELKVIVALTLLHFELLPDPTRVPEPLARIVLKSKNGIYLHLKKLH* 15767279
CYP4A33P rat
UCSC browser exons 5-12
135689623 DKWEQIVGQDSTLEIVQHNTLMTLDTIMKCAFSQEGSVQLDR 135689766
135690074 KYKSYIKAVGDLNNLSFFRIWNIFHQNDIIYSLSSNGCQANSAC*LAHEHT 135690238
135690647 DQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFAR 135690760
135690855 IENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITW 135691046
135691147 DDLDKMPYTTMCIKEALSIYPPVPSVSRMLSTPVTFPDGCSLPK 135691278
135692145 PKGITAVLSFYGHHHNPTL*PNPE 135692213
VFDPYRVFPXSSQHSHLFLPFSGGAR 135692425
135700661 NCIGKQFAMNELKVAIALTLLCLRLLPDPTRIPIPIPRLVLKSKNGIYLHLKKLQ 135700825
CYP4A33P-de4b5b12b rat
UCSC browser (upper line is the new sequence)
frag d in fig. below
135662099-135662209 (+ strand) F exon 4
Query: 9457 LSNDQTWFQH*HILTPLFHYGILKTNVRIIVDSVHEM 9347
L N + WFQH +LTP FHYGILK V+I+ DSV+ M
Sbjct: 130 LLNGKKWFQHRRMLTPAFHYGILKPYVKIMADSVNIM 166
135671387-135671512 (+ strand) G exon 5
Query: 169 DISDSLEIFQCASLIALATIMMCAFSYQDNVHLNRSVTSQSF 44
D LEIF SL+ L T+M CAFS+Q +V L+ V S+S+
Sbjct: 175 DQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLD--VNSRSY 214
135676914-135677039 (+ strand) S exon 12
Query: 93402 KQFIMNEMKVVITLTLLCFEWLLDPTRVSVSISGFLLNPRMG 93277
KQF MNE+KV + LTLL FE L DPTR+ + I +L + G
Sbjct: 458 KQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNG 499
human, mouse and rat 4ABXZ clusters
CYP4A33P-de10c11c rat
UCSC browser (upper line is the new sequence)
frag e in fig. below
135712750-135712827 (+ strand) exon 10
Query: 57566 GVLISFSICGLHHNPRLWPNAEV*NP 57489
G+ + S GLHHNP +WPN EV +P
Sbjct: 406 GITVMLSFYGLHHNPTVWPNPEVFDP 431
135713048-135713125 (+ strand) R exon 11
Query: 57271 QVFDPFRFAPDVLRHTHAFLPFSAGAR 57191
+VFDP+RFAP+ RH+H+FLPFS GAR
Sbjct: 427 EVFDPYRFAPESSRHSHSFLPFSGGAR 453
human, mouse and rat 4ABXZ clusters
CYP4A34P rat
UCSC browser
new pseudogene seq between 4A3 and 4A2 T
65% to 4A2 135837702-135845966 (+ strand)
MGIFELSHITTVFGISRLLQMVFWLGLLLLLFKAAQYYLRRQWIIKSFQQFPFPPSHWLFGNFLK
135838759 KDQDLQQIRLWVEKFPTACVRWFWGNHACVLIYDPD*MKVILG*S 135838887 aa 65-107
(exon 3 in a seq gap)
GYSLLLLNGKKWFQHRQMLTPAFHSDILKPYVGIMA
FSIFLLQDKWEELVGQDCPLEIYQDISLMTMETLINCAFSYQGSVQLE
NSRS*IKAVEDLTHLIHFRVRNGFH*SNIIYNLSSNGGSFHCACQIAHKHKG
DRVIRRRKVQLQSGVELEKIWKKWHLDLLDILLFAQ
EDGKSLSDEDLHAEVDTFMFEGHDTAARGISWIFYALPTHPEHQERCKEEVQSILGDGTSVTW
DHLDQMPYTTMCIKKALRLYPPGPAVSRELSTPVTFPDGCSSPKNSRISVV
IFGLHHNPRL*PNPE
VLDPFRFAPDVPQHTHAFLPFSAGAR
NCIRKLFAMNELKVAVTLTLL*LELLPDPTRVPFLVARTVLKSKIRIYLHLKKLK
CYP4A34P-de12b rat
UCSC browser
C-term aa 453-508 with one frameshift
frag f in fig. below
This may be the C-term of a full gene with the rest in a seq gap
135831318 RNCIGEHFAMNELKVAMALTLL 135831383
135831383 QFELLPDPTRIPIPIPRLVLKSKNGIYLHLKKLQ 135831484
human, mouse and rat 4ABXZ clusters
CYP4A35 Balaenoptera acutorostrata (Minke whale)
AB290011
Iwata Hisato
submitted to nomenclature committee 1/6/05
81% to CYP4A11 human
MSVSVLSPTRALGGVSGLLQVASLLGLVLLLLKAAQLYLHRQWL
LKALQQFPSPPSHWLYGHMQEFQEETELRPLLKRVEKYPSACARWLWGTKALVLVYDP
DYMKVVLGRSDPKSHDSYRLLIPWIGNGLLLLERQTWFQHRRMLTPAFHYDILKPYVG
LMADSVRVMLDKWEELVSLDSHLEVLGHVSLMTLETIMKCAFSHQGSIQTDRNIQSYI
QAIRDLGNLTFSRIRNAFHQNDFIYRLTPEGRWSHRACQLAHQHTDAVIKLRKAHLQK
EGELEKVRSKRHLDFLDILLFARMENGSSLSDVDLRAEVDTFMFEGHDTTASGISWIL
YALASHPEHQQRCREEIQSLLRDGASITWDHLDKMPYTTMCIKEALRLYPPVPVISRD
MSKPITFPDGRSLPAGIPLSLSFYGLHHNPKVWPNPEVFDPSRFAPGSDRHSHAFLPF
SGGSRNCIGKQFAMNEMKVAVALTLLRFELAPDPSRVPVPIPRVVLKSKNGIHLQLRK
LL
CYP4A36 Canis familiaris (dog)
UCSC Genome browser June 13, 2005
This gene has a sequence gap that includes exons 5-9
75% to CYP4A11 human, 73% to CYP4A22 human
16550556-16550750 exon 1
16553600-16553740 exon 2
16554459-16554503 exon 3
16554973-16555101 exon 4
16574267-16574332 exon 10
16574473-16574550 exon 11
16577168-16577332 exon 12
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKTAQLYQRRQWMLKAIQQFPSPPSHWFFGHKQE
FQTGLELQELKKRTEKYRCASPLWLWGSRVSLIVYDPDYMKMIPGRS
DPKSEGAYRFMAPWI
GYGLLLLNGEIWFQHRRMLTPAFHYDILKPYVRLMVDSVQVML
DKWEELLSQNSHLEIFEHVSLMTLDTIMKCAFRYQGNH*ADR
NFQSYIQAIKDLNYLVFSRMRNVFYQKDIFYWLTSEGRRNHKACQLAHEHT
DRVIKLRKAQLQDEGELEK
VRNKRHLDFLDISFFAK
MENGRGLSDKDLRAEVDTFKFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASIT*
EHLDQMPYTTMCIKEALRLYLPVPTVGRELSKPITFPDGRSLPR
GFLVLLSFYALHHNSNVWPNPE
VFDPSRFAPDASRHSHAFLPFSGGSR
NCIGQHFAMKEMKVAVALTLLRFELAPDPFRIPVPTPKIVLMSKNGIHLHLRKLL*
CYP4A36-de10b11b12b Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15 adjacent to CYP4X1
16531225-16531290 exon 10
16531430-16531507 exon 11
16533933-16534070 exon 12
GFLVLLSFYALHHNPNVWPNPE
VFDPSHFAPDASRHSHAVLPFSGGAR
XXXXXXXXXNELKVAVALTLLRFELAPDPFRIPVSTPKIVLMSKNGIHLHLRKLL*
CYP4A37 Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
chr15 16582305-16601179
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQHRQWLLKAVQQFPSPPSHWFFGHKQE (0)
FQTGQELQVFQKWTEKYPCACPRWLWGSRVSLVVYDPDYMKMILGRS (1)
DPKAGGSYTFITPWI (1)
GYGLLLLHGEAWFQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDMNNLVFARVRNVFYQKDIFYGLTSEGRRNHKARQIAHQHT (1)
DRVIKLRKAQLQDEGELEKVRNKRHLDFLDILLFAK (0)
MENGKGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPK (1)
GFLVSLSFYALHHNPNVWPNPE (0)
VFDPSRFAPDASRHSHAFLPFSGGSR (2)
NCIGKHFAMNELKVAVALTLLRFELAPDPFKIPVPTPRIVLMSKNGIHLHLRKLL
CYP4A37 Canis familiaris (dog, beagle)
No accession number
Richard Graham
submitted to nomenclature committee 6/9/05
mRNA 99% identical to boxer 4aa diffs
clone name: group 1
CYP4A38 Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16616983-16617177 exon 1
16620038-16620178 exon 2
16627267-16627311 exon 3
16627767-16627895 exon 4
16629076-16629201 exon 5
16629573-16629725 exon 6
16630161-16630268 exon 7
16630360-16630551 exon 8
16630646-16630777 exon 9
16632476-16632541 exon 10
16632700-16632759 exon 11 frameshift extra "A" base
16634726-16634891 exon 12
MSVSLLSLTRPLDTVSGFLQVASLLGLALLLLKAAQFYWHRQWLLKAIQQFPSPPSHWFFGHRQE (0)
FQKGRELQELKKRTEKYPCASPRWLWGSRVSLVVYDPDYMRMILGRS (1)
DPKSDGSYRLMAPWI (1)
GYGLLLLNGEIWFQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLTQNSHLEIFEHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDLNNLVFARVRNVFYQKDIFYGLTSEGRRNHKACQLAHEHT (1)
DRVIKLRKAQLQDEGELEKIRNKRHLDFLDILLFAK (0)
MENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPGVGRELSKPITFPDGRSLPR (1)
GFLVLLSFYALHHNPNVWPNPE (0)
VFDPSRFAPDASRHSHAFLPFSGGSR (2)
NCIGQHFAMNELKVAVALTLLRFELAPDPFRIPVPTPRIVLMSKNGIHLHLRKLL*
CYP4A38 Canis familiaris (dog, beagle)
No accession number
Richard Graham
submitted to nomenclature committee 6/9/05
mRNA 100% identical to boxer except for frameshift
clone name: group 2
CYP4A38 Canis familiaris (dog, beagle)
No accession number
Richard Graham
submitted to nomenclature committee 6/9/05
mRNA 99% identical to boxer, 4 aa diffs
clone name: group 3
CYP4A39 Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chr 15 16641912-16651675
MSVSVLSLTRPLDTVSGLLQLASLLGLALLLLKAAQLYQRRQWLLKAVQQFPSPPSHWLFGHKRE (0)
LQKGDELQLLLKWIEDFPCAFSRWIWGTEAEIMIYDPDYMKLILGRS (1)
DPKPDGSYKLMAPWI (1)
GYGLLLLNGETWSQHRRMLTPAFHYDILKPYVRLMADSVQVML (0)
DKWEELLSQNSHLEIFDHVSLMTLDTIMKCAFSYQGNHQADR (2)
NSQAYIQAIRDLNNLVFARMRNVFYQKDIFYGLTSEGRRNHKACQLAHQHT (1)
DRVIKLRKAQLQDKGELEKVRNKRHLDFLDILLFAK (0)
VENGRGLSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPEHQQRCREEIQSLLGDGASITW (2)
EHLDQMPYTTMCIKEALRLYPPVPNVGRELSKPITFSDGRSLPK (1)
GFLVLLSFYALHHNPNVWPNPE (0)
VFDPSRFAPGVSRHSHAFLPFSGGSR (2)
NCIGQHFAMNEMKVAVALTLLRFELAPDPFRIPVPTPKIVLMSKNGIHLHLRKLL*
CYP4A39-de12b Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16655566-16655718 exon 12 (-) strand)
NCIGQQFAMNEMKVVTALCLLRFEFALDPLQLPVKMPQLILRSKNGIHLHL
CYP4A39-de9b Canis familiaris (dog, boxer)
UCSC Genome browser June 13, 2005
Chromosome 15
16657179-16657292 exon 9
XXXXXMTYLTMCIKESFRLYPPVPQVYRQLSKPVNFVDGRSLPX
CYP4A40 Bos taurus (cow)
See cattle page for details
MSVSALSPSRALGGVSGLLQVVSLLGLVLLLIKAAQLYLRRQWLLKALHHFPSPPSHWFCGHKWE
FQEEGELPHLLKRVEKYPRACVRWMWGTRALLLVYDPDYMKMVLGRS
DPKAQIIHRFVKPWI
GTGLLLLEGQTWFQHRRMLTPAFHYDILKPYVGIMADSVRVML
DKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSQQGSVQTDR 369
SSQSYIQAIKDVSHLIISRLRNAFHQNDLIYRLTPEGHWNHRACQLAHQHT 895
DAVIKERKVRLQKEGELEKVRSRRHLDFLDILLFAR 1445
MENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQS 1690
LLADGASITW
DHLDQMPYTTMCIKEAMRLYPPVPVISRELSKPITFPDGHSLPA 1952
GILVSLSIYGLHHNPKVWPNPE
VFDPTRFAPGSTRHSHAFLPFSGGSR 3927
NCIGKQFAMNELKVAVALTLLRFELSPDSSRVPVPMPVIVLRSKNGIHLQLRKLSDPGGDK
CYP4A41 Bos taurus (cow)
See cattle page for details
MSVSVLSPTRALGGVSGLLQVVSLLGLVLLLLKAAQLYLRRQWLLKALHQFPSPPSHWFYGHKKE
FQKESELPPLLERVEKYPKACVRWLWGTKALVLVYDPDYMKVFLGRS
DPKPHRTYKYLAPWI
GTGLLLLEGQKWFQHRRMLTPAFRYDILKAYVGIMADSVRVML
DKWEELVSQDSHLEIFGHVSLMTLDTIMKCAFSHQGSVQMDR
SSQSYIQAIRDLSHLIVSRLRNAFHQNDLIYRLTPEGRWNHRACQLTHQHT
DAVIKERKAHLQKEGELEKVRSRRHLDFLDILLLAR
MENGSSLSDEDLRAEVDTFMFEGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITW
DHLDQMRYTTMCIKEAMRL
YPPVPFIGRELRKPITFPDGRSLPA
GILVSLSFYGLHHNPNVWPNPE
VFDPTRFSPGSTQHSYAFLPFSGGSR
NCIGKQFAMNELKVAVALTLLRFELSPDPSRVPVPTPIMVLRSKNGIHLQLRKLSDPGGDKDKL
CYP4A42P Bos taurus (cow)
See cattle page for details
KEKELEELLKRVEEFPYAYPCWMWG
DNVHLVVYDPDYMKVVLRRS
NPKSEDIYRFLAPWI
GLLLLEEQTWFQHRQMLTPAFHYDILKPYLGLMADSVQGML
DKWEELVSQDSHLEILGDISLMTLDTIMKCVFSH*GSIRNDR
XXXXXXXXXXXXXXXXXXXLRNVFYQNDLIYRLTPEGQWSY
XXXXXXXXX
TDAVIEERKTCLRKEGELEKVRSRRHLDFLDILLFSRV
NGSSLSDEDLRAEVDTFIFGGHDTTASGISWILYALASHPEHQQRCREEIQSLLGDGASITW
CYP4A43P human = CYP4A-se2[1]
GenEMBL NT_04852.13 - strand exon 1
7994933 MSVSVLNPNRLPDGVSGLLQGASLLSLLLLLLKAAQP*LHR 7994811
CYP4A44P human = CYP4A-se4[2]
GenEMBL NT_04852.13 exon 2 - strand
8003576 XXXDQELKQFQKWVDF*IYPKRDFCDPVLTCCGGRKVHFLLYDPDKMEVILGRS 8003424
CYP4A-se1[12] human = CYP4A26P
AL731892.5
76% to 4A11 C-term upstream of 4A11
TCIGKKFAMNEL 135092
135091 KVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRV 134966
NT_04852.13 - strand
7968299 TCIGKKFAMNELKVAMALTLLRFELLPDPTRIPVGIP*ILLKFKSGIHLHLRRVPNHCGDKDQL* 7968105
CYP4A-se2[1] human = CYP4A43P
GenEMBL NT_04852.13 - strand exon 1
7994933 MSVSVLNPNRLPDGVSGLLQGASLLSLLLLLLKAAQP*LHR 7994811
CYP4A-se3[12] human = CYP4A27P
AL731892.5
67% to 4A11 C-term
168353 SAWLRNCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRL 168183
NT_04852.13 - strand exon 12
8001510 NCIGKQFAMNELKVALTLLNFKLFSDPASIPILLPQMVLKFNNGIHLHVKRLPNTCEDKNQI* 8001322
CYP4A-se4[2] human = CYP4A44P
GenEMBL NT_04852.13 exon 2 - strand
8003576 XXXDQELKQFQKWVDF*IYPKRDFCDPVLTCCGGRKVHFLLYDPDKMEVILGRS 8003424
CYP4A rabbit
PIR PQ0048 (25 amino acids)
Kikuta, Y., Kusunose, E., Okumoto, T., Kubota, I. and Kusunose,M.
Purification and characterization of two forms of cytochrome
P-450 with omega-hydroxylase activities toward
prostaglandin A and fatty acids from rabbit liver
microsomes.
J. Biochem. 107, 280-286 (1990)
This fragment has 2 differences with 4A7
4B Subfamily
CYP4B1 human
GenEMBL NM_000779 J02871
Nhamburo,P.T., Gonzalez,F.J., McBride,O.W., Gelboin,H.V. and
Kimura,S.
Identification of a new P450 expressed in human lung: Complete cDNA
sequence, cDNA-directed expression and chromosome mapping
Biochemistry 28, 8060-8066 (1989)
CYP4B1 human
GenEMBL X16699
Yokotani,N., Sogawa,K., Matsubara,S., Gotoh,O., Kusunose,E.,
Kusunose,M. and Fujii-Kuriyama,Y.
cDNA cloning of cytochrome P-450 related to P-450p-2 from the cDNA
library of human placenta. Gene structure and expression
Eur. J. Biochem. 187 (1), 23-29 (1990)
CYP4B1 Pan troglodytes (chimp)
XM_513140.3 5 aa diffs to CYP4B1 human
Missing the N-term
GRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVA VFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYL AVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDE KVQKKIQNRRHLDFLDILLGAWDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLY CMALYPEHQHRCREEVREILGDQDSFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQL SKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDPLRFSTENASKRHPFAFMP FSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLCSKNGFHLHLK
PLGPGSGK
CYP4B1 Macaca mulatta (rhesus monkey)
NM_000779
95% to human 4B1
MVPSFLSLRLSCLGLWASGLILVLGFLKLIRLLLRRQRLAKAMGNFPGPPTHWLFGHALE (0)
IQQTGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRG (1)
DPKAPDVYDFFLQWI (1)
GRGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML (0)
DKWEEKAQEGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHR (2)
DSSYYLAVSDLTLLMQQRLVSFHYHNDFIYWLTPHGRRFLRACQVAHDHT (1)
DQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGAR (0)
DEDDSKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDSFQW (2)
DDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA (1)
GSLISMHIYALHRNSAVWPDPE (0)
VFDPLRFSTENASKRHPFAFMPFSAGPR (2)
NCIGQQFAMSEMKVVTAMCLLHFEFSLDPSRLPIKMLQLVLRSKNGIHLHLKPLGPGSGK
CYP4B1 rat
GenEMBL M29853
Gasser,R. and Philpot,R.M.
Primary structures of cytochrome P-450 isozyme 5 from rabbit and
rat and regulation of species-dependent expression and induction in
lung and liver: Identification of a new cytochrome P-450 gene
subfamily IVB
Mol. Pharmacol. 35, 617-625 (1989)
CYP4B1 rabbit
GenEMBL M29852
Gasser,R. and Philpot,R.M.
Primary structures of cytochrome P-450 isozyme 5 from rabbit and
rat and regulation of species-dependent expression and induction in
lung and liver: Identification of a new cytochrome P-450 gene
subfamily IVB
Mol. Pharmacol. 35, 617-625 (1989)
CYP4B1 rabbit
GenEMBL AF176914
Mastyugin,V., Aversa,E., Bonazzi,A., Vafaes,C., Mieyal,P. and
Schwartzman,M.L.
Hypoxia-induced production of 12-hydroxyeicosanoids in the corneal
epithelium: involvement of a cytochrome P-4504B1 isoform
J. Pharmacol. Exp. Ther. 289 (3), 1611-1619 (1999)
CYP4B1 Canis familaris (dog)
XM_845151.1
86% to CYP4B1 human
MVSTLLSLSVSHLVLWATGLILVLGFLKLIRLLLRRQMLARAMD
SFPGPPTHWLFGHAQEIQQTGSLDKVVTWAHQYDYAHPLWLGPFLGFLNIYEPDYAKA
VYSRGDPKAADVYDFFLQWIGKGLLVLQGPKWYQHRKLLTPGFHYDVLKSYVAVFTNS
THAMLDKWEEKAREDKSFDIFCDVGYMALDSLMKCTFGKGDSSLGHRDSSYYSAVRDL
TLLMQQRIESFQYHNDFIYWLTPHGRRFLRACQAAHDHTDQVIRERKAALQDEKEQEK
IQNRRHLDFLDILLGARDENGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALY
PQHQHRCREEVCEILGDRDSFQWDDLVKMTYLTMCIKESFRLYPPVPQVYRQLSKPVN
FVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSSENVARRHPFAFMPFSAGP
RNCIGQQFAMNEMKVVTALCLLRFEFALDPLQLPVKMPQLILRSKNGIHLHLKSLRLG
SGK
Cyp4b1 mouse
GenEMBL D50834 (1871bp)
Imaoka,S., Hiroi,T., Tamura,Y., Yamazaki,H., Shimada,T., Komori,M.,
Degawa,M. and Funae,Y.
Mutagenic activation of 3-methoxy-4-aminoazobenzene by mouse renal
cytochrome P450, CYP4B1: Cloning and characterization of mouse
Cyp4b1.
Arch. Biochem. Biophys. 321, 255-262 (1995)
Cyp4b1 mouse
GenEMBL NT_039264.1 - strand
15793364 MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALE 15793185
15787670 IQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRG 15787524
15787339 DPKAAYVYDFFLQWIGK 15787289
15786110 GKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVML 15785982
15782099 DKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSH 15781943
15781704 SDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHT 15781552
15781416 DHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGAR 15781309
15774536 DESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQW 15774345
15772616 DDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPA 15772485
15771566 GSLISLHIYALHRNSAVWPDPE 15771501
15771405 VFDPLRFSPENMTGRHPFAFMPFSAGP 15771325
15770907 RNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKPLGPGSGK 15770725
Cyp4b1-de2b4b mouse
GenEMBL NT_039264.1 - strand
v in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15690726 DLDKVGTWTEQFPYAHPLWLGQFVVFLNIYEPDYSKAVYSQA 15690601
15689190 GKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVML 15689062
Cyp4b1-de10c11c12c mouse
GenEMBL NT_039264.1 - strand
u in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
15728822 GSLISLHIYALHRNSAVWPDPE 15728757
15728661 VFDPLRFSPENMTGRHPFAFMPFSAGP 15728581
15728149 RNCIGQQFAMNKMKVV 15728102
15728100 TALCLLCFEISQDPLKIPIKVPQLILGSKNGIHLYLKPLGPGSGK 15727966
CYP4B1 wallaby
No accession number
Ross McKinnon
Submitted to nomenclature committee Dec. 2, 2002
Clone name W4B2
73% to mouse Cyp4b1
CYP4B1 Sus scrofa (pig)
AK231936.1
CJ022616.1 BP435822.1 CF179484.1 AW480803.1 CJ026219.1
BP440482.1
80% to human 4B1, 81% to cow 4B2
MVPALLSLSLSHLSLWALGLILALGVLKLTSLLLRRQMLARAMDK
FPGPPTHWIFGHALEIQQTGSLDKMVSWAHQFPHAHPLWLGPFLGFLNIYEPEYAKAVYS
RGDPKASDLYDFFLQWIGKGLLVLHGPKWFQHRKLLTPGFHHDVLKPYVAVMANSARVML
DKWEEKAREDKSFDIYHDVGHMALELLMKC
TFGKGTSGLNYSDNAYHLAVRDLTLLMQQRLSSFQYHNDFIYWLTPHGRRFLRACRVAHD
HTDQVIRERKAALQDKEEQERIQSRRHLDFLDILLGAQDEDRVKLPDADLRAEVDTFMFG
GHDTTTRGISWFLYCMSLNPEHQHRCRDEIREILGDRDSIQGEDLGKMTYLTMCIRESFRLYPP
GPQVYRQLSEPVSFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRH
PFAFLPFSAGPRNCIGQQFAMNEMKVVAALSLLRFEFAPDPSRPPIPMPQLTLCSKTGIH
LRLTSLGQGSGK*
CYP4B1 Bos taurus cattle
GenEMBL AW347853
Differs from 4B2 shown below
This seq is 100% match to pig 4B1 (possible contamination?)
Efforts to extend this sequence in genomic DNA have failed
3 DGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSLENMAGRHPFAFLPFSAGPRNC 179
CYP4B2 Bos taurus (cow)
See cattle page for details
94% to goat 4B2 only 82% to human 4B1
note: there was some evidence for two CYP4B genes in cow,
but only one can be found in the genomic data so far.
This may be the CYP4B1 ortholog and 4B1 may be a pig sequence.
MVPVLLSLSLSHLSLWAFALVSVLVFLKLTRLLLRRQMLARAMDRFSGPPTHWLFGHALE
IQQTGSLDKVVSWTHEFPYAHQLWVGQFLGFLNIYDPDYAKAVYSR
GDPKAPDFYDFFLQWI
GKGLLVLQGPKWFQHRKLLTPGFHYDVLKPYVALFAESTRVML
DKWEKKAREQKSFDIYSDVGHMALDSLMKCTFGKGTSGLNDR
DNNYYLSVKELTLLMQQRIDSFQYHNDFIYFLTPHGRRFLRACQVAHDHT
DQVIRERKAALQDEKERERIQSKRHLDFLDILLGAW
DEEGIKLSDEDLRAEVDTFMFEGHDTTTSAISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKW
DDLAEMTYLTMCIKESFRL
YPPVPQVYRQLSQPVNFVDGRSLPE
GSLISLHIYALHRNSTVWPDPE
VFDPLRFSPENVAGRHSFAFIPFSAGPR
NCIGQQFAMAEVKVVTALCLLRFEFSPDPSRLPIKMPQLVLRSKNGIHLHLKPLGPGSEK*
CYP4B2 Capra hircus (goat)
AY151046
Garold Yost
Submitted to nomenclature committee August 2002
82% to human 4B1, 94% to bovine 4B2
MVPVLLSLSLSHLSLWAFGLVSVLVFLKLTRLLLRRQMLARAMD
RFSGPPTHWLFGHALEIQQTGGLDKVVYWTHQFPYAHQLWLGRFLGFLNIYDPEYAKA
VYSRGDPKAPDVYDFFLQWIGKGLLVLQGPKWFQHRKLLTPGFHYDVLKPYVAVFAES
ARVMLDKWEKKAREQKSFDIFSDVGHMALDSLMKCTFGKGTSGLNDRDNNYYLAVSEL
TLLMQQRIDSFQYHNDFIYFLTPHGRRFLRACQVAHDHTDQVIRERKAALQDKKEREK
IQSKRHLDFLDILLGARDEEGIKLSDEDLRAEVNTFMFAGHDTTTSAISWVLYCMSLY
PEHQRRCREEIQEILGDRDSLKWEDLAEMTYLTMCIKESFRLYPPVPQVYRQLSKPVN
FVDGRSLPAGSLISLHIYALHRNSTVWTDPEVFDPLRFSPENVAGRHSFAFIPFSAGP
RNCIGQQFAMNEVKVVTALCLLRFEFSPDPSKLPIQMPQLVLRSKNGIHLHLKPVGPG
SEK
CYP4B2 Bos taurus cattle
GenEMBL BF602740
94% to goat 4B2 only 82% to human 4B1
3 AISWVLYCMSLYPEHQRRCREEIQEILGDRDTLKWDDLAEMTYLTMCIKESFRLYPPVPQ 182
183 VYRQLSQPVNFVDGRSLPEGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENVARRHSFA 362
363 FIPFSAGPRNCIGQQFAMAEVKVVTALCLLRFEFAPDP 476
CYP4B3 wallaby
No accession number
Ross McKinnon
Submitted to nomenclature committee Dec. 2, 2002
Clone name W4B1
69% to mouse Cyp4b1
4C Subfamily
CYP4C1 Blaberus discoidalis (cockroach)
GenEMBL M63798 Swiss P29981 (511 amino acids)
Bradfield,J.Y., Lee,Y.-H. and Keeley,L.L.
Cytochrome P450 family 4 in a cockroach: Molecular cloning and
regulation by hypertrehalosemic hormone
Proc. Natl. Acad. Sci. U.S.A. 88, 4558-4562 (1991)
CYP4C2 Anopheles albimanus (mosquito)
GenEMBL L38678 (379bp) PIR PC2257 (126 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
Cyp4c3 Drosophila melanogaster
GenEMBL U34323(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4c3 Drosophila melanogaster
AC014779 73845-80196 also AC008219
Cyp4c3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4C4 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071073
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C4
Unpublished
CYP4C5 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071074
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C5
Unpublished
CYP4C6 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071075
Andersen,J.F. and Feyereisen,R.
Cockroach fat body CYP4C6
Unpublished
CYP4C7 Diploptera punctata (Pacific beetle roach)
GenEMBL AF071072
Andersen,J.F. and Feyereisen,R.
CYP4C7, a P450 from cockroach corpora allata
Unpublished
CYP4C8 Mastotermes darwiniensis (Australian termite)
GenEMBL U77126(432bp)
Falckh,P.H.J., Balcombe,W.M., Haritos,V.S. and Ahokas,J.T.
Isolation, identification and sequence of a cytochrome P450 in an
Australian termite, Mastotermes darwiniensis.
unpublished (1996)
note: 92 amino acid C-terminal fragment
CYP4C9 Coptotermes acinaciformis (termite)
GenEMBL AF046008
Patrick Falckh
C4-8_9-A
CYP4C10 Coptotermes acinaciformis (termite)
GenEMBL AF046009
Patrick Falckh
C4-8_9-I
CYP4C11 Mastotermes darwiniensis (Australian termite)
GenEMBL AF067631
Quoc Wu
M4-150.4
CYP4C12 Mastotermes darwiniensis (Australian termite)
GenEMBL AF067632
Quoc Wu
M4-100-8
CYP4C13 Mastotermes darwiniensis (Australian termite)
GenEMBL AF067633
Quoc Wu
M4-240-2
CYP4C14 Coptotermes acinaciformis (termite)
GenEMBL AF067634
Quoc Wu
4F-22_24
CYP4C15X Orconectes limosus (crayfish)
GenEMBL AF091117
Chantal Dauphin-Villemant
submitted to nomenclature committee
this is a tentative assignment, this sequence may require its own
subfamily
50% identical to 4C1 over full length, 58% identical over C-terminal
renamed CYP4V11
CYP4C16X Penaeus setiferus (shrimp)
GenEMBL AF072854
Mark Snyder
submitted to nomenclature committee
renamed CYP4V12
CYP4C17X Haliotis rufescens (red abalone)
GenEMBL AF072853
Mark Snyder
submitted to nomenclature committee
renamed CYP4V13
CYP4C18X Homarus americanus (lobster)
GenEMBL AF072852
Mark Snyder
submitted to nomenclature committee
renamed CYP4V14
CYP4C19 Lytechinus anamesis (sea urchin)
GenEMBL AF072850
Mark Snyder
submitted to nomenclature committee
first sequence from sea urchin
CYP4C20 Lytechinus anamesis (sea urchin)
GenEMBL AF072851
Mark Snyder
submitted to nomenclature committee
second sequence from sea urchin
CYP4C21 Blattella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee Dec. 30, 1998
CYP4C22v1 Culex pipiens pallens (mosquito)
GenEMBL AF157093
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 150 amino acids
clone name NYDR2 81% identical to 4C2
this sequence has one frameshift
EVDTFMFEGHDTTSAAISWILLLLGAEPAIQDRIVEEIDEIMGG
DRDRFPTMKELNDMKYLECCIKEGLRLYPSVPLIARKLVEDCVVQDYTIPAGTTAMIV
VYQLHRDPAVFPNPDKFNPDHFAPENCRGRHPYAYIPFMAGPRNCIGH
CYP4C22v2 Culex pipiens
AF208659
Changliang Zhu
Clone NYDS6 PCR fragment 97% identical to 4C22v1
Submitted to nomenclature committee 9/30/99
TSAAISWILLLLGAEPAIQDRIVEEIDQIMGGDRDRFPTMKELN
DMKYLECCIKEGLRLYPSVPLIARQLVEDCVVQDYSIPAGTTAMIVVYQPHRDPAVFP
NPDKFNPDHFAPENCRGRHPYAYI
CYP4C23 Culex pipiens pallens (mosquito)
GenEMBL AF157090
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 167 amino acids
clone name NYDS1 84% identical to AF117650 at C-terminal 44 amino acids
this sequence has numerous frameshifts and insertions/deletions it may
be a pseudogene
MFEGHDTTAAGIILTIMLPANEQDAQRRVYEDLSKARRLKPEHE
AFTIADYTNLKYLDRFVKEALRLYPPVSFISRSLTGRLDVGRYSKLPVNQILVHIELL
NRSHHHLAARNYRQHSHLRSAPYPEQFPDPERFDPDRFLPEVSAKRNPYAYVPFCAGP
RNCIGH
CYP4C24X Orconectes limosus (crayfish)
no accession number
C. Dauphin-Villemant, M. Tom, M. Waterman and D. Bšcking
submited to nomenclature committee 6/15/99
name changed to CYP4V21, 86% to CYP4V18
CYP4C25 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450Q
CYPb1x3 on chromosome 1
91% identical to 4C2
CYP4C25 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x3
CYP4C25 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 5
98% identical to CYP4C25 Anopheles gambiae probable ortholog
only 2 amino acid differences
CYP4C26 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450S
CYPb1x1 on chromosome 1
73% identical to 4C2
CYP4C26 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x1
CYP4C27 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450I
CYPo3r3 on chromosome 3
58% identical to 4C6
CYP4C27 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r3
CYP4C28 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450R
CYPs3l1 on chromosome 3
61% identical to 4C2
CYP4C28 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3l1
CYP4C29X Cherax quadricarinatus (crayfish)
No accession number
Moshe Tom
Submitted to nomenclature committee May 4, 2000
Clusters with the other crayfish sequence 4C24 on trees
Reanmed CYP4V15
CYP4C30 Coscinasterias muricata Australian sea star (11 armed starfish)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
63% to 4C19 partial seq. from I-helix to heme
CYP4C31 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.5 203 aa
65% to 4C24 crayfish 65% to 4C16 shrimp 69% to 4C18 lobster
68% to 4C17 abalone 82% to 4C33
CYP4C32 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.6 149 aa
95% to 4C34
CYP4C33 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.14 200 aa
62% to 4C24 crayfish 61% to 4C16 shrimp 66% to 4C18 lobster
66% to 4C17 abalone 82% to 4C31
CYP4C34 Daphnia pulex (Daphnia, water flea)
No accession number
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.16 206 aa
61% to 4C24 crayfish 63% to 4C16 shrimp 64% to 4C18 lobster
65% to 4C17 abalone 95% to 4C32
CYP4C35 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r1
CYP4C36 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPo3r2
CYP4C37 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPb1x2
CYP4C38 Aedes aegypti (yellow fever mosquito)
CYP4C38 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.4
CYP4C38 Culex pipiens
CYP4C39X Carcinus maenas (shore crab)
GenEMBL AY328467
Kim Rewitz
submitted to nomenclature committee 6/18/2003
59.5% to 4C15
renamed CYP4V16
CYP4C40 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 3 same as contig2
88% to 4C36
probable ortholog of 4C35
note 4C35 is only 84% to 4C36 and less to all other gambiae CYP4Cs
CYP4C41 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 9
93% to 4C27
probable ortholog of 4C27
CYP4C42 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4C
83% to 4C3 (106 aa)
CYP4C43v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #2v1
72% to 4C8 I-helix to heme, 99.5% identical to CYP4C43v2
CYP4C43v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #2v2
71% to 4C8 I-helix to heme, 99.5% identical to CYP4C43v1
CYP4C44v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #3v1
88% to 4C14 I-helix to heme, 99.5% identical to CYP4C44v2
CYP4C44v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #3v2
88% to 4C14 I-helix to heme, 99.5% identical to CYP4C44v1
CYP4C45v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #4v1
66% to 4C13 I-helix to heme, 99.7% identical to CYP4C45v2
CYP4C45v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #4v2
66% to 4C12 I-helix to heme, 99.7% identical to CYP4C45v1
CYP4C46 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #5
86% to 4C14 I-helix to heme
CYP4C47 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #6
61% to 4C13 I-helix to heme
note name may change when full seq is known
CYP4C48 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #7
90% to 4C9 I-helix to heme
CYP4C49X Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 58_23_ext
63% identical to CYP4C17 Haliotis rufescens (red abalone) partial seq.
renamed CYP4V10, one aa difference to CYP4V10v1
CYP4C50 Aedes aegypti (yellow fever mosquito)
CYP4C50v1 Culex pipiens
CYP4C50v2 Culex pipiens
CYP4C51 Aedes aegypti (yellow fever mosquito)
CYP4C51v1 Culex pipiens
CYP4C51v2 Culex pipiens
CYP4C52 Aedes aegypti (yellow fever mosquito)
CYP4C52v1 Culex pipiens
CYP4C52v2 Culex pipiens
CYP4C53 Daphnia magna (water flea)
GenEMBL AB257772
Yoshinori Ikenaka
Submitted to nomenclature committee 8/28/06
CYP family-2, full length sequence
70% to CYP4C31, amino acids 88 to end 55% to 4V2 human
The CYP4C subfamily in invertebrates may be the orthologous
group to the chordate CYP4V sequences
CYP4C53 Daphnia pulex (water flea)
CYP4C54X Litopenaeus vannamei (Pacific white shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
58% to 4C39 shore crab, 64% to 4C32 Daphnia, 62% to 4C31 Daphnia,
49% to 4C25 Anopheles, 48% to 4C53 Daphnia, 47% to 4C3 Drosophila
Clone name Lv03
Renamed CYP4V17
CYP4C55 Daphnia pulex (water flea)
CYP4C56 Daphnia pulex (water flea)
CYP4C57 Daphnia pulex (water flea)
CYP4C58 Daphnia pulex (water flea)
CYP4C59 Daphnia pulex (water flea)
CYP4C60 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4C61 Nilaparvata lugens (Homoptera: Delphacidae) brown planthopper
No accession number
Zhifan Yang
Submitted to nomenclature committee 5/23/08
Clone CYP4-2
55% to CYP4C62, 47% to CYP4C27
CYP4C62 Nilaparvata lugens (Homoptera: Delphacidae) brown planthopper
No accession number
Zhifan Yang
Submitted to nomenclature committee 5/23/08
Clone CYP4-6
55% to CYP4C1
CYP4C62 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
96% to CYP4C62 Nilaparvata lugens (brown planthopper)
presumed ortholog, missing C-term
CYP4C62 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
96% to CYP4C62 Nilaparvata lugens (brown planthopper)
presumed ortholog, complete seq. 2 aa diffs to Jia Shuangs seq.
CYP4C63v1 Trialeurodes vaporariorum (whitefly)
CYP4C63v2 Trialeurodes vaporariorum (whitefly)
CYP4C64 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
52% to CYP4CS1 Trialeurodes vaporariorum (whitefly)
CYP4C65 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf52
87% to CYP4C61 Nilaparvata lugens
CYP4C66 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf46
73% to CYP4C1 cockroach
CYP4C67 Diaphorina citri Kuwayama (Asian citrus psyllid)
No accession number
Siddharth Tiwari
Submitted to nomenclature committee April 7, 2011
75% to CYP4C63v1 whitefly
CYP4C68 Diaphorina citri Kuwayama (Asian citrus psyllid)
No accession number
Siddharth Tiwari
Submitted to nomenclature committee April 7, 2011
65% to CYP4C1 cockroach
CYP4C69 Locusta migratoria manilensis
No accession number
Xiaoyu Ren
Submitted to nomenclature committee Nov. 8, 2011
54% to CYP4C62 Laodelphax striatellus
CYP4C70 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
63% to CYP4C62, incomplete
CYP4C71 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
55% to CYP4C62, 82% to CYP4C61 Nilaparvata lugens, complete
CYP4C72 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
70% to CYP4C52 Aedes aegypti, EXXR to heme
CYP4C73 Locusta migratoria manilensis
No accession number
Xiaoyu Ren
Submitted to nomenclature committee Sept. 13, 2012
60% to CYP4C64 Bemisia tabaci, 58% to CYP4C1 cockroach
55% to CYP4C69 Locusta migratoria
4D Subfamily
Cyp4d1 Drosophila melanogaster
GenEMBL X67645 (1675bp) Swiss P33269 (511 amino acids)
PIR S25707 (511 amino acids)
Gandhi,R., Varak,E. and Goldberg,M.L.
Molecular analysis of a cytochrome P450 gene of family 4 on the
Drosophia X chromosome.
DNA Cell Biol. 11, 397-404 (1992)
note: X67645 has a probable frameshifts at the C-terminal
see Z98269 and AF016992 to AF017004 for correct end
Cyp4d1 Drosophila melanogaster
GenEMBL AC017770 49988-51720
Alternative splice AC017770 48817-51720
Cyp4d1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4d1_v1b Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
(alt splice, exon 1)
Cyp4d2 Drosophila melanogaster
GenEMBL Z23005 (1481bp) X75955 (1883bp) PIR S41192 (496 amino acids)
Frolov,M.V. and Alatortsev,V.E.
Cluster of cytochrome P450 genes on the X-chromosome of
Drosophila melanogaster
DNA Cell Biol. 13, 663-668 (1994)
probable frameshift at C-terminal
see Al009194 and AF017006 to AF017019 for correct end
Cyp4d2 Drosophila melanogaster
GenEMBL AC017770 comp(32267-34028)
Cyp4d2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4D3v1 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4d3v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
68% to 4d1 D. pseudoobscura
3 aa diffs to 4D3v1
CYP4D4v1 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4d4v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
57% to 4d14 D melano.,
100% to 4D4v2 (PCR fragment), 4 aa diffs to 4D4v1
CYP4D5 Anopheles albimanus (mosquito)
GenEMBL L38679 (382bp) PIR PC2270 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4D6 Anopheles albimanus (mosquito)
GenEMBL L38680 (446bp) PIR PC2271 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4D7 Anopheles albimanus (mosquito)
GenEMBL L38681 (447bp) PIR PC2272 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
Cyp4d8 Drosophila melanogaster
GenEMBL U34329(385bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Dro-G453 (formerly called 4N3)
Cyp4d8 Drosophila melanogaster
GenEMBL AC017388 comp(37292-39859)
also AC010557 AC010112 AC010113
Cyp4d8 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4D9 Musca domestica
Rene Feyereisen
no accession number
6-full
submitted to nomenclature committee
CYP4D10 Drosophila mettleri
GenEMBL U91634
Jim Fogleman
full length sequence 288mt
submitted to nomenclature committee (one of 109 sequences)
CYP4D11 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD60 PCR of C-terminal
CYP4D12 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD5 PCR of C-terminal
CYP4D13 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD84 PCR of C-terminal
Cyp4d14 Drosophila melanogaster
GenEMBL AL009194 comp(10685-12421)
also submitted by Michael Goldberg
55% identical to Cyp4d2
Cyp4d14 Drosophila melanogaster
GenEMBL AC017770 35699-37438
Cyp4d14 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4D15 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450E
77% identical to 4D6
CYP4D15 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r3
CYP4D16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450F
84% identical to 4D6
CYP4D16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r5
CYP4D17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450H
79% identical to 4D5
CYP4D17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r4
CYP4D18v1 Culex pipiens
GenEMBL AF190775
Changliang Zhu
Clone NYDS2 PCR fragment 95% identical to 4D18v2, 66% to 4D6
Submitted to nomenclature committee 9/30/99
TTSAMSFILGILAKHPEVQKKAYDEVRNVFGDDPSKPATLAMLN
ELNYLDMVIKETLRLYPSVPMFGRKMLENHDIGKFWQRNAVLLVKLNAPKPLPYGTIF
PAGSNVIVMPYIMGRDPEYFDDPLEFRPERFAVETSAEKSNPYRYV
CYP4D18v2 Culex pipiens
AF191728
Changliang Zhu
Clone NYDR16 PCR fragment 95% identical to 4D18v1
Submitted to nomenclature committee 9/30/99
TTSAMSFLLGVLAKHPEVQKKAYDEVRNVFGDDPSKPATLAMLN
ELNYLDMVIKETLRLYPSVPIFGRKMLENHDIGKFWHRNAVLLVKLNAPKPLPDGTIF
PAGSNVIIMPYIMGRDPDYFDDPLEFRPERFAVETSAEKSNPYRYV
CYP4D19 Culex pipiens
CPIJ009477
CYP4D19v1 Culex pipiens
AF190786
Changliang Zhu
Clone NYDR11 PCR fragment 3 diffs with 4D19v2
Submitted to nomenclature committee 9/30/99
TSGVSFTLYNLAKYPTIQQKVHDEIIAVLGTDPHKPVTMATLNE
LTYLEMVIKETLRLFPSVPIIGRKCVEEVTIEGKTVPAGTNIIIGIYYMGRDANYYDN
PLEFIPERFEGEKSVEKFNPYKYV
CYP4D19v2 Culex pipiens
AF190789
Changliang Zhu
Clone NYDR14 PCR fragment 3 diffs with 4D19v1
Submitted to nomenclature committee 9/30/99
TTSGVSFTLYNLAKYPAIQQKVHDEIIAVLGTDPHKPVTMATLN
ELTYLEMVIKETLRLFPSVPIIGRKCVEEVTIEGKTVPAGTNIITGIYYMGRDANYYD
NPLEFIPERFEGEKSVGKFNPYKYV
CYP4D19v3 Culex pipiens
GenEMBL AF190777
Changliang Zhu
Clone NYDS4 PCR fragment 95% identical to 4D19v2, 54% to 4D5
Submitted to nomenclature committee 9/30/99
TTSGVSFTLYNLAKYPTIQQKVHDEIIAVLGTDPHKPVTMATLN
ELTYLEMVIKETLRLFPSLPIIGRKCVEEVTIEGKTVPAGTNIIIGIYYMGRDANYYD
NPPELIPERFEGEKSVEKFNPYKYV
Cyp4d20 Drosophila melanogaster
GenEMBL AC019509 comp(19731-21636)
Cyp4d20 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4d21 Drosophila melanogaster
GenEMBL AC020004 55466-57280
CYP4D22 Anopheles gambiae (malaria mosquito)
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450O
50% identical to 4H5, 4H7
note the 4H subfamily might really be considered two differernt
subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.
4H20 falls between these. Revised seq now groups with CYP4Ds
formerly CYP4H20
CYP4D22 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r6
CYP4D23 Aedes aegypti (yellow fever mosquito)
CYP4D23v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.8
CYP4D23v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.3
CYP4D23v3 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.1
CYP4D24 Aedes aegypti (yellow fever mosquito)
CYP4D24 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.6
CYP4D25 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 5
94% to 4D22
probable ortholog of 4D22
CYP4D26 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 8
85% to 4D15, 78% to 4D27
CYP4D27 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 10
86% to 4D17 78% to contig 10 possible ortholog of 4D17
79% to 4D16 and 80% to 4D15
CYP4D28 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D1
55% to 4D2 (276 aa)
CYP4D29v1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D2
56% to 4D2 (278 aa)
CYP4D29v2 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0103K16
57% identical to Drosoph. CYP4d2 only 5 aa diffs to 4D29v1 98%
CYP4D30 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D3
82% to 4D3 (150 aa)
CYP4D31 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D4
72% to 4D4 (149 aa)
CYP4D32 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D5
72% to 4D2 (149 aa)
CYP4D33 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D6
63% to 4D2 81% to 4D29 (149 aa)
CYP4D34 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4D7
61% to 4D20 81% to 4D33 (150 aa)
CYP4D35 Musca domestica (house fly)
No accession number
Nannan Liu
50% identical to 4d8, 79% to 4D36
clone #12
submitted to nomenclature committee 4/10/06
CYP4D36 Musca domestica (house fly)
No accession number
Nannan Liu
61% identical to 4d4 fragment, 79% to 4D35
clone #12prime
Missing C-term after EXXR motif
submitted to nomenclature committee 4/10/06
CYP4D37 Aedes aegypti (yellow fever mosquito)
CYP4D38 Aedes aegypti (yellow fever mosquito)
CYP4D39 Aedes aegypti (yellow fever mosquito)
CYP4D40 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 2
84% to 03, 67% to 4D24 Aedes
96% (5 aa diffs out of 127) to CYP4D18v2 AF191728 Culex pipiens
CYP40 and CYP41 may be paralogs of CYP4D18
CYP4D40 Culex pipiens
CYP4D41 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 3
60% to CYP4D16 Anoph. 66% to 4D24 Aedes
96% (5 aa diffs out of 127) to CYP4D18v2 AF191728 Culex pipiens
CYP40 and CYP41 may be paralogs of CYP4D18
CYP4D41 Culex pipiens
CYP4D42 Culex pipiens pallens
CB074945.1
NJS1618(2) 488bp, NJ008 in Genbank entry
58% to CYP4H12v5, 77% to 4D22, 84% to 4D23
GRGNSIEVDTFMFEGHDTTTIAITFTLMLLAKHPDIQEKVYQEVTEIIGKDLNAPTTYRN
LQDMKYLELVIKESLRLYPPVPIIGRKFTEKTEIDGKVVPEDSNFNVGIILMHRDPTQFE
DPERFDPERFSPERTTELSSPYAYIPFSAGPRNCIGQNH
CYP4D42v1 Culex pipiens
CYP4D42v2 Culex pipiens
CYP4D43 Culex pipiens pallens
CB074951.1
NJS1618(4) 488bp, NJ008 in Genbank entry
57% to CYP4D42 70% to 4D16
GRGNSIEVDTFMFEGHDTTTSAISFLMYRLARHPEVQRKVYEEIVAVIGADRDRPVTLAM
LNELHYLELVVKETLRLYPSVPFYGRKILENCEIEGRTFPAGANVIIMPFFMGRDSEYFE
DPQKFRPERFAVGTSAEKTNPYRYIPFSAGPRNCIGQNH
CYP4D43 Culex pipiens
CYP4D44 Culex pipiens
CYP4D45P Culex pipiens
CYP4D46 Bactrocera dorsalis (Oriental fruit fly)
GU292422 (not released yet 2/1/2010)
Jiang Hongbo
submitted to nomenclature committee 1/28/2010
55% to CYP4d8 Drosophila melanogaster
CYP4D47 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
66% to Cyp4d1 Drosophila melanogaster
CYP4D48 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
56% to CYP4D4v2 housefly
CYP4D or 4AR Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4I1.3
CYP4D or 4AR Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T1.6
4E Subfamily
Cyp4e1 Drosophila melanogaster
GenEMBL AC020402 44580-46698
CYP4E1 HAS INSERT AT C-TERM VSKDGYISTTLGLQPAEKKSRDAHNHK
Cyp4e2 Drosophila melanogaster
no accession number
Amichot, M., Brun, A., Cuany, A., Helvig, C., Salaun, J. P., Durst, F.
and Berge, J. B.
Expression study of CYP genes in drosophila strains
resistant or sensitive to insecticides. In: Cytochrome P450
Lechner M.C. ed. John Libbey Eurotext, Paris.pp. 689-692 (1994)
(PCR fragment) 144 amino acid region
Cyp4e1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4e2 Drosophila melanogaster
GenEMBL X86076(1408bp)
Amichot,M., Brun,A., Cuany,A., LeMouel,T. and Berge,J.
Cloning and expression study of CYP4E2 a novel P450 gene in
drosophila.
unpublished (1995)
Cyp4e2 Drosophila melanogaster
GenEMBL U56957(1458bp) U34332(373bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4e2 Drosophila melanogaster
GenEMBL AC020402 41848-44099
Cyp4e2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4e3 Drosophila melanogaster
GenEMBL U34330(370bp)
Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B.,
ffrench-Constant, R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251, 290-297 (1996)
DroG4-2
Cyp4e3 Drosophila melanogaster
GenEMBL AC020324 73117-75125
Cyp4e3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4e4x Drosophila melanogaster
GenEMBL U34331(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
formerly called 4N4
note: this sequence is pretty far out in the 4E subfamily
it has been reassigned as Cyp4ae1
CYP4E5 Drosophila mettleri
GenEMBL U78486
Phil Danielson
Mt1
CYP4E6 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD21 PCR of C-terminal
CYP4E7 Musca domestica (house fly)
no accession number (530 amino acids)
Claus Tittiger and Gary Blomquist
submitted to nomenclature committee
CYP4E8 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4E
70% to 4E2 (150 aa)
CYP4E9 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
61% to Cyp4e2 Drosophila melanogaster
4F Subfamily
CYP4F1 rat
GenEMBL S53039 M94548 (1977bp) Swiss P33274 (524 amino acids)
PIR S29723 (524 amino acids)
Chen,L. and Hardwick,J.P.
Identification of a new P450 subfamily, CYP4F1, expressed
in rat hepatic tumors.
Arch. Biochem. Biophys. 300, 18-23 (1993)
Note: rat 4F1 has an alternatively spliced 3 prime untranslated exon
CYP4F2 human
GenEMBL U02388 (2368bp)
Chen,L. and Hardwick,J.P.
The human liver CYP4F2 cDNA sequence and expression in
baculovirus-infected cells.
unpublished (1993)
CYP4F2 human
GenEMBL D26480 (2227bp)
Kikuta,Y., Kusunose,E., Kondo,T., Yamamoto,S., Kinoshita,H. and
Kusunose,M.
Cloning and expression of a novel form of leukotriene B4
omega-hydroxylase from human liver
FEBS Lett. 348, 70-74 (1994)
CYP4F2-ie2b human = CYP4F63P
CYP4F2-de12b human CYP4F36P
NT_011281.4|Hs19_11438
chromosome 19 detritus exon 12 75% TO 4F11
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448
CYP4F2 Pan troglodytes (chimpanzee)
XM_001172535.2
98% to human
MSQLSLSWLGLGPVAASPWPLLLLVGASWLLAHVLAWTYAFYDN CRRLRCFPQPPRRNWFWGHQGMIHSSEEGLLYAQSLACTFGDMGCWWVGPWQAIVRIF HPTYIKPVLFAPAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL KPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP SEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR TLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLH PPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENI KERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA
EGGLWLRVEPLS
CYP4F3 human
GenEMBL D12620 (2073bp) D12621 (1185bp) S63604 (2073bp)
Swiss Q08477 (520 amino acids)
Kikuta,Y., Kusunose,E., Endo,K., Yamamoto,S., Sogawa,K,
Fujii-Kuriyama,Y. and Kusunose,M.
A novel form of cytochrome P-450 family 4 in human
polymorphonuclear leukocytes. cDNA cloning and expression of
leukotriene B4 omega-hydroxylase.
J. Biol. Chem. 268, 9376-9380 (1993)
Note: three overlapping clones F-22, A-4 and M-6 are identical.
Clone S-8 is different at 4 nucleotides and one amino acid.
CYP4F3 human
GenEMBL AD000685 12 exons from 26660-44629
CYP4F3-ie2b human = CYP4F64P
CYP4F3 Pan troglodytes (chimp)
7 aa diffs to CYP4F3 human
UCSC genome browser chr19:15933453-15951437 (+) strand
MPQLSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCRRLRCFPQPLKRNWFLGHLGL
IHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAP
AAIVPKDKVFYSFLKPWL
GDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMH
AKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQE
KPSEYIAAILELSALVTKRHQQILLYIDFLYYLTHDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVDDFLQAKAKSKTLDFIDVLLLSK
DEDGKKLSDEDIRAEADTFMFE
GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEW
DDLAHLPFLTMCMKESLRLHPPVPAVSRCCTQDIVLPDGRVIPK
GIICLISVFGTHHNPAVWPDPE
VYDPFRFDPKNIKERSPLAFIPFSAGPR
NCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVE
CYP4F3v2 human
GenEMBL AF054821
Kanga Morgan
alternative splice variant of 4F3 with a cryptic exon at amino acids
67-114 this exon resembles the region in 4F2.
CYP4F3v2 Macaca fasicularis (cynomolgus monkey)
DQ074799
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F2#2
88% to 4F3v1, 94% to AF054821
one exon may be alternate splice this is the case in humans
MPQLSLSSLGLGPVAVSPWLLLLLIGVSWLLARVLAWTYTFYDN
CRRLRCFPQPPKRNWFWGHLGLVTPTEQGMRVLTQLVATYPQGFKVWMGPIIPVIRFC
HPNLIRSVINASAAIVPKDKLFYSFLKPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL
KPYMKIFNESVNIMHAKWQLRASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
SEYIAAILELSALVAKRHQQFFLYIDFLYYLTHDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVEDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTA
SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFVTMCIKESLRLH
PPVPAISRCCTQDIVLPDGRVIPKGVICHISVLGTHHNPAVWPDPEVYDPFRFDPENI
KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA
EGGLWLRVEPLS
CYP4F4 rat
GenEMBL U39206
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F5 rat
GenEMBL U39207
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F6 rat
GenEMBL U39208
Kawashima, H. and Strobel, H.W. (1995)
BBRC 217, 1137-1144
CYP4F7 Dicentrarchus labrax (European sea bass)
GenEMBL AF045925
Sabourault C, Amichot M, Pauron D, Berge JB, Lafaurie M, Girard JP
Cloning of CYP4F7, a kidney-specific P450 in the sea bass Dicentrarchus
labrax.
Biochem Biophys Res Commun 258, 155-61 1999
62% identical to human 4F3
authors name CYP4Dl2
Query: 1 GHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKES 60
GHDTTAS + W LY+LA+H +YQE+CRQEV EL++ R+ EIEW+DL+ LPF TMCI+ES
Sbjct: 1 GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES 180
Query: 61 LRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPK 120
LRLH PV AV+R TQD+ LP +PKG ICL+S++GTHHNP VW +P + P RFDP
Sbjct: 181 LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT 360
Query: 121 NIKERSPLAFIPFSAGPRNCIGQAFAMAE 149
N + + AFIPFS+GPRNCIGQ FA+AE
Sbjct: 361 NKEGLAAHAFIPFSSGPRNCIGQKFALAE 447
Sequence of reported protein may have 2 frameshifts at the end
See alignment below to human 4F3 as query
Possible corrected sequence
GHDTTASAICWTLYNLARHDQYQEKCRQEVMELMEGRDRHEIEWEDLSNLPFTTMCIRES
LRLHSPVQAVTRKYTQDMTLPGDCTVPKGAICLVSIYGTHHNPTVWTNPHEFHPLRFDPT
NKEGLAAHAFIPFSSGPRNCIGQKFALAELRVVVALTLLRFRLTLGVNPEVGPSSGEVRR
LPQLVLRAEGGMWLQVEPL
Score = 85 (29.9 bits), Expect = 6.3e-62, Sum P(2) = 6.3e-62
Identities = 23/59 (38%), Positives = 31/59 (52%), Frame = +2
Query: 132 PFSAGPRNCIGQAFAMAEMKVVLGLTLLAFRVL--------PDHTEPRRKPELVLRAEG 182
PF P + ++ ++VV+ LTLL FR+ P E RR P+LVLRAEG
Sbjct: 395 PFPQAPGTALVRSSPWQRLRVVVALTLLRFRLTLGVNPEVGPSSGEVRRLPQLVLRAEG 571
Score = 54 (19.0 bits), Expect = 1.2e-58, Sum P(2) = 1.2e-58
Identities = 10/18 (55%), Positives = 12/18 (66%), Frame = +3
Query: 174 PELVLRAEGGLWLRVEPL 191
P L GG+WL+VEPL
Sbjct: 546 PSLSCVQRGGMWLQVEPL 599
CYP4F8 human
GenEMBL AD000685 13 exons from 862-14599
GenEMBL AF133298
Bylund, J., Finnstršm, N. and Oliw, E. H. (1999) Gene Expression of a
Novel Cytochrome P450 of the CYP4F subfamily in Human Seminal Vesicles.
Biochem. Biophys. Res. Commun. 261, 169-174.
submitted to nomenclature committee 10/30/98
81.2% identity with CYP4F2 and 76.7% with CYP4F3.
EST AI401776, AI349730
CYP4F8 Pan troglodytes (chimpanzee)
XM_001172317.2
98% to human
MSLLSLSWLGLRPVAASPWLLLLVVGASWLLAHILAWTYAFYHN CRRLRCFPQPRKQNWFLGHLGLVTPTEEGLRVLTQLVATYPQGFVRWLGPITPIINLC HPDIVRSVINTSDAITDKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNIL KPYIKIFSKSANIMHAKWQHLAMEGSTCLDVFEHISLMTLDSLQKCIFSFESNCQEKP SEYITAIMELSALVVKRNNQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDTVIQERRR TLTSQGVDDFLQAKAKSKTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTA SGLSWVLYNLARHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCLKESLRLH PPIPIFARGCTQDVVLPDSRVIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENA QKRSPMAFIPFSAGPRNCIGQKFAMAEMKVVLALTLLRFRILPDHREPRRTPEIVLRA
EDGLWLRVEPLG
CYP4F9P HUMAN
GenEMBL AC004609 complement(13903-33104 region)
pseudogene N-terminal not on this cosmid, may be on adjacent cosmid
missing 71 amino acids at N-terminal
69% identical to 4F3 67% identical to 4F8
EGMRVLTQLVATYPQGFKIWMNPITPIIRLCHPNIIWSVINASATIAPKD
EAFYKFLKPWLGDGLLVNASDKWSCHRQMLMPAFHFNMLKPYMKFFTDSV
NIMHAKWQLLASGGSAHLDMFEHTSLMTLDSVQKCVFSFDSHCQEKPSQYIATI
LELSSLFSXXXXXXXLCMDFLYYLIPSGWRFRRACCLVHDFTEAIIQEQRH
TLTSQGVDYFHEVKAKSKTLDFTDVLLLSKXXXXXXXXXXXXXXXXXXXXXX
GHNTTASGLSWVLYYLARHPEYQEHCWQEVQKLLKDHEPKEIEX
DDLAQLPFLTMYIKDSLWLHPPVPVISRCCTQDIVLPGG*VIPKGIVCLF
SNFETHHNPTVWLDPEVYDPFRFDPENSKERSPLAFIPFSAGSX
NCIGQAFAMAEMKVVLALTLLCFRVCPDHMEPRRKPEVIMYAEGGLWLWVKPLS
CYP4F10P human
GenEMBL AD000685 exons 3-6 (cosmid ends in middle of exon 6)
49350 to end of cosmid. Cannot recognize exons 1 and 2 after 4F3 gene
ends at 44623 and before exon 3 starts at 49350. May be a pseudogene
(No ESTs)
SATIAPKDKVFYSFLKPWLG
DGFLLSAGDKWSCHRGMLMPAFHFNILKPYMKIFDESVNIMH
AKWHLLTLEHNACLDMFEHMNLMTLDSLQKCVFSFDSQCQE
KPSEYIASVLELSSLVAKRNQQ
CYP4F11 human
GenEMBL AC005336 cosmid F20129 end of cosmid
ESTs T56269 and T56204 opposite ends of clone yb89b03
ESTs T69576 and T69645 opposite ends of clone yc44c03
EST AA991369 and EST W23003
N-terminal up though C helix and C-terminal from I helix to end is
Present middle region is not present. The rest of this gene should be
on cosmid R28342 this is not in the database yet. About 22 amino acids
missing at N-terminal
N-terminal is on AC011517 rest is on AC020950
MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQC
FPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLI
LCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRML
TPAFHFNLKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDS
LQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQR
FRRACHLVHDFTDAVIQERRRTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKD
EDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEV
QELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDG
RVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFNQENIKERSPLAFIPFSAGP
RNCIGQAFAMAEMKVVLALTLLHFRILPTHIEPRRKPELILRAEGGLWLRVEPLGANSQ
CYP4F11 Pan troglodytes (chimpanzee)
XM_003339308
98% to human
MPQLCLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYTFYDN CRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILC HPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNIL KPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP SEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRR TLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTA SGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLH PPVPVISRCCTQDIVLPDGRVIPKGIVCLINIIGLHYNPTVWPDPEVYDPFRFDQENI KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRA
EGGLWLRVEPLGANSQ
CYP4F11 Macaca fasicularis (cynomolgus monkey)
DQ074800
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F11_2-E5
91% to 4F11 human 80% to 4F12 human
MLQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDN
CRHLQCFPQPPKQNWFWGHQGLVTPTEEGMKKVTQLVATYPQGFKFWMGPTFPLLTLC
HPDTIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNIL
KPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHLSLMTLDSVQKCVFNFESNCQEKP
SEYIAAILELSALIEKRNQHILVYPDFLYHLTPDGQRFRRACRLVHDFTDAVIQERRQ
TLRTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFGGHDTTA
SGLSWVLYHLAQHPEYQERCRQEARELLKDCEPVEIEWDDLAQLPFLTMCIKESLRLH
PPVPAVSRCCTQDIVLPDGRIIPKGIICIISIFGIHHNPTVWPDPEVYDPFRFYQENI
KERSPLAFIPFSAGPRNCIGQVFAMAEMKVVLALTLLRFRILPTHPEPCRKPELVLRT
EGGLWLRVEPLGVNSQ
CYP4F12 human
GenEMBL AC004523 missing N-terminal
UNIGENE entry Hs.110130 (12 ESTs)
UNIGENE Hs.168862 R08175 and R08229 (opposite end)
Complete cDNA sequence submitted by Johan Bylund June 16, 2000
mRNA for cytochrome P450, complete cds. AB035130
MSLLSLPWLGLRPVAMSPWLLLLLVVGSWLLARILAWTYAFYNN
CRRLQCFPQPPKRNWFWGHLGL
ITPTEEGLKDSTQMSATYSQGFTVWLGPIIPFIVLC
HPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNIL
KSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP
SEYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRR
TLPTQGIDDFFKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTA
SGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRCCTQDIVLPDGRVIPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENS
KGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRRKLELIMRA
EGGLWLRVEPLNVGLQ
CYP4F12 Pan troglodytes (chimp)
XM_524141.3 96% to CYP4F12
MSLLSLPWLGLRQVAISPWLLLLLVVGSWLLTRILAWTYAFYNN CRRLQCFPQPPKRNWFWGHLGLITPTEEGLKDSTQMSATYSQGFTIWLGPIIPFIVL
CHPDTIRSITNASAAIALKDDLSIRFLKPWLGDGLLLSGVDKWSRHRRMLTPAFHFN
ILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQ
ERPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIR
ERRRTLPTQGIDDFLKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGG
HDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVK
ESLRLHPPAPFISRCCTQDIVLPDGRVIPKGITCVINIIGVHHNPTVWPDPEVYDPF
RFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHTEPRR
KPELIMRAEGGLWLRVEHLNVGLQ
CYP4F12 Macaca fasicularis (cynomolgus monkey)
DQ074801
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F12_2-G6
91% to 4F12 human 82% to 4F11 human
MSLLSLPWLGLGPVATSPGLLLMLVVGSWLLARVLAWTYASYDN
RRRLQCFPQPPKQNWFWGHLGLITPTEEGLKNLTQISATYSQGFMIWMGPIIPFIVLC
HPDTIRSITNASAAIAPKDALSIRFLKPWLGEGILLSGGDKWSHHRRMLTPAFHFNIL
KPYIKIFNKSATIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSRCQERP
SEYIATILELSALVEKRSQHILQYMDFLYYLTQDGRRFRRACRLVHDFTDAVIQERRR
TLPTQGIDDFLKDKAKSKTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFAGHDTTA
SGLSWILYNLVRHPEYQERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLH
PPAPFISRHCTQDIVLPDGRVIPKGIICVINITGVHHNPTVWPDPEVYDPYRFDPENS
KERSPLAFIPFSAGPRNCIGQAFAMAEMETVLALMLLHFRFLPDHTEPRRKPELILRA
EGGLWLRVEPLSAGLQ
Cyp4f13 mouse
GenEMBL ESTs AI304244 ui64h08.y1, AA277579 va77c04.r1
AA238458 my34d11.r1, AA277631 va81d08.r1
AI265156 uj03h07.y1, AI120320 ub69c04.r1
AI327511 mb31b06.y1, AA245188 mx09e08.r1
AA799238 vx69h12.r1, AA797204 vw22d08.r1
AI196488 ui64h08.x1, AI196852 ui67e09.x1
AA511038 vh55g04.r1,AI323999 mb31b06.x1
W64560 md70f05.r1, AI121221 ud70e01.x1
Unigene Mm.22045
89% identical to rat CYP4F6 probable ortholog
CONSENSUS
MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWF
WGHLALMKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQASAAVAPKEMTLYGFLKP
WLGDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMHAKWQCLASKGTSRLD
MFEHISLMTLDSLQKCIFSVDSNCQESDSKYIAAILELSSLVVKRHRQP
FLYLDLLYYLTADGRRFRKACDLVHNFTDAVIKERRSTLNTQGVEFLKAKAKTKTLD
FIDVLLMAEDEHGKGLSNEDIRAEADTFMFGGHDTTTSALSWILYNXXXXXXXXXXXXX
EVQELLRDRDSEEIEWDDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAI
PKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPENPQKRSPLAFIPFSAGTRNCIGQTFA
MSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ*
Cyp4f13 mouse
GenEMBL NT_039649.1|Mm17_39689_30 - strand.
seq gap at exon 7,8
Mm.22045 15 ESTs follow AI323999 BF533850 BC003954 AF233643
9512124 MLQLCLSWLGMGSLTASPWHLLLLGGASWILARILAWIYAFYDNCSRLRCFPQPPKPSWFWGHLAL 9511927
9506326 MKNNEESMQFITHLGHDFHDVHLSWVGPVYPILRLVHPNFIAPLLQA 9506186
9497701 SAAVAPKEMTLYGFLKPWL 9497645
9497556 GDGLLMSAGDKWSHHRRLLTPAFHFDILKSYVKIFNKSVNIMH 9497428
9495574 AKWQCLASKGTSRLDMFEHISLMTLDSLQKCIFSVDSNCQE 9495452
9495033 SDSKYIAAILELSSLVVKRHRQPFLYLDLLYYLTADGRRFRKACDLVHNFT
DAVIKERRSTLNTQGVEFLKAKAKTKTLDFI 9494788
DVLLMAE
DEHGKGLSNEDIRAEADTFMFGG
HDTTTSALSWILYNLARHPEYQERCRQEVQELLRDRDSEEIEW
9490318 DDLAQLPFLTMCIKESLRLHPPVLLISRCCTQDVLLPDGRAIPK 9490187
9490098 GNICVISIFGVHHNPSVWPDPE 9490033
9489902 VYNPFRFDPENPQKRSPLAFIPFSAGT 9489822
9489452 RNCIGQTFAMSEIKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSAGAQ* 9489273
Cyp4f14 mouse
GenEMBL ESTs
AI098768 ue38c01.y1
AI047403 ud65h03.y1
AI099192 ue40b11.y1
AA237519 mx10h12.r1
AA793220 vl85g08.r1
AA869706 vq44d03.r1
AI118365 ue40b11.x1 chimeric clone contains a-L-Fucosidase
AA880205 vx39b01.r1
consensus N-terminal to 370
MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWL
MGHVGMVTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALK
DVIFYSILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQR
VISDGSAPLDMFEHVSLMTLDSLQKCVVFSFDSNCQEKSSEYIAAILELSALVAK
KDQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLD
FIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLARHPEYQERCRQE
VQELLRGREPEE
gap of 69 amino acids
Cyp4f14 Cterminal 439-524
AI046446 ud65h03.x1 C-term
AA274495 vb07d01.r1 C-term
AI121221 ud70e01.x1 C-term
consensus
VYDXFRFDPENIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVE
PLSAGAH*
UNIGENE entry Mm.10976 (C-terminal part only)
92% identical to rat CYP4F1 probable ortholog
Cyp4f14 mouse
GenEMBL NT_039649.1|Mm17_39689_30 - strand
80% to 4f15
Mm.10976 C-term only. AF233644 AK018676 AC073720 91k-108k
9480783 MSQLSLSWLGLGPEVAFPWKTLLLLGASWILARILIQIYAAYRNYRHLHGFPQPPKRNWLMGHVGM 9480586
9478580 VTPTEQGLKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNA 9478440
9475637 SAAVALKDVIFYSILKPWL 9475581
9475492 GDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMH 9475364
9475203 AKWQRLISDGSARLDMFEHVSLMTLDSLQKCVFSFDSNCQE 9475081
9473316 KSSEYIAAILELSALVAKRHQQPLMFMDLLYNLTPDGMRFRKACNVVHEFTDAVIRERHRTLPDQGLDDFLKSKAKSKTLDFIDVLLLSK 9473047
9471961 DEDGKELSDEDIRAEADTFMFEG 9471893
9471699 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRGREPEEIEW 9471571
9470493 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGRTIPK 9470362
9470279 GIICLISIFGIHHNPSVWPDPE 9470214
9470056 VYDPFRFDPENIKDSSPLAFIPFSAGP 9469976
9469605 RNCIGQTFAMSEMKVALALTLLRFRLLPDDKEPRRQPELILRAEGGLWLRVEPLSAGAH* 9469426
Cyp4f15 mouse
GenEMBL ESTs
AI315840 uj47c01.y1
AI046615 ud70e01.y1
AI048594 ud61g02.y1 this clone skips over exons
MPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWF
LGHLGMITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNASASVALK
EVVFYSFLKPWLGDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQH
LALGGSARLDVFENISLMTLD
AI048594 ud61g02.y1 407-480
AI121221 ud70e01.x1 C-term this fragment also is an exact match to 4f13 and 4f14
There may have been gene conversion at the C-terminal of these three genes.
LLPDGRVIPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPFSAGPR
NCIGQTFAMNEMXVXXXXXXXXXXXXPDDKEPRRKPELILRAEGGLWLRVEPLSTQ
No UNIGENE entry for these ESTs
92% identical to rat CYP4F4 probable ortholog
Cyp4f15 mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
Mm.26539 AF233645 1EST AI121221 AK018904
MGFF
9250760 RMPQLDLSWLGLRLEASSPWLLLLLIGASWLLARVLTQTYIFYRTYHHLCDFPQPPKWNWFLGHLGM 9250960
9255347 ITPTEHGLKEVTNLVATYPQGFMTWLGPIIPIITLCHPDIIRSVLNA 9255487
9257115 SASVALKEVVFYSFLKPWL 9257171
9257260 GDGLLLSDGDKWSSHRRMLTPAFHFNILKPYVKIFNDSTNIMH 9257388
9259977 AKWQHLASGGSARLDVFENISLMTLDSLQKCVFSFDSNCQE 9260099
9262477 NPSEYISAILELSALVTKRYHQLLLHIDSLYQLTCSGRRFHKACHLVHSFTDAVIQDRRRTLPSKHEDDVLKAKAKSKTLDFIDVLLLSK 9262746
9264634 DEDGKELSDEDIRAEADTFMFEG 9264702
9264910 HDTTASGLSWILYNLARHPEYQERCRQEVQELLRDRESTEIEW 9265038
9266608 DDLAQLPFLTMCIKESLRLHPPVTVISRRCTQDIVLPDGRVIPK 9266739
9266828 GVICIINIFATHHNPTVWPDPE 9266893
9267035 VYDPFRFDPENIKDRSPLAFIPFSAGP 9267115
9267490 RNCIGQTFAMNEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSTQ* 9267663
Cyp4f16 mouse
GenEMBL ESTs AA059667 mj77a08.r1
AA863889 vx15d11.r1, AA673923 vo83a09.r1
AA798644 vw34b12.r1, AA896484 vx63d12.r1
MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWF
SGHLGMIQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWL
GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMF
EHISLMTLDSLQKCLFGFDSNCQESPSEYISAILELSSXXXXXXXXXXXXXXX
Cyp4f fragment a 93% identical to 4F5 88% to 4F6, 86% to 4F1 83% to 4F4
This fragment belongs to Cyp4f16
AA671839 vl02c09.r1
AA755081 vu02b08.r1
LYYHTADGRRFRKACDLVHNFTDAVIRERRHTLSSQNHDEFLKSKTKSKTLDFIDVL
LLAKDEHGKELSDEDIRAEADTFMFGGHDTTASALSWILYNLARHPEYQERCRQRVQE
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHSPVIDXXXXXXX
Cyp4f fragment c 91% identical to 4F6, 86% to 4F1 and 4F5, 85% to 4F4
This fragment is part of Cyp4f16
AA688499 vq53e04.r1
AA791143 vv91d10.r1
AI036012 vz68a09.r1
AA794692 vu63c06.r1
DIVLXXXXXXPKGNICVISIFGIHHNPSVWPDPEXXX
PFRFDPENPQKRSPLAFIPFSAGPRNCIGQTFAMSEM
KVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ*
92% identical to rat CYP4F5 probable ortholog
Cyp4f16 mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
AF233646 AK009445 no UNIGENE entry ESTs AA059667 mj77a08.r1
9097626 MLRLSVSGLDLGSVVTSSWHLLLLGVASWILARILAWTYSFYENCSRLSCFPQPPKKNWFSGHLGM 9097823
9100841 IQSNEEGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQA 9100981
9103307 ALVAPKDMTFLRFLKPWL 9103360
9103446 GDGLFLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH 9103574
9104679 AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE 9104801
9105455 SPSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR 9105622
9105623 ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK 9105724
9106943 DEHGKELSDEDIRAEADTFMFGG 9107011
9107206 HDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEW 9107334
9110828 DDLAQLPFLTMCIKESLRLHSPVIDLLRRCTRDIVLPDGRVIPK 9110959
9111076 GNICVISIFGIHHNPSVWPDPE 9111141
9111306 VYDPFRFDPENPQKRSPLAFIPFSAGP 9111386
9111628 RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLSKGAQ* 9111807
Cyp4f17 mouse
GenEMBL ESTs AA387122 vc22e06.r1, AA386914 vc23b12.r1
AA387149 vc22f06.r1
MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWF
WGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQASAAVAPK
EMIFYGFLKPWLGDGLLVSAGEKWSRH
66% to CYP4F6 but 81% identical to a rat EST AI030199
The rat homolog to this gene has not been cloned yet.
Cyp4f17 mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
AC073754 (5 exon 9s) no UNIGENE entry
9067942 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPSRHWFWGHMSM 9068139
9078921 VKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGPILQAS 9079064
9081387 AAVAPKEMIFYGFLKPWLG 9081443
9081530 DGLLVSAGEKWSRHRHLLTPAFHFDILKPYMKNFNKSVNIMH 9081655
9083143 AKWQRLTTKGTACLDMLEHISLMTLDSLQNCVFSFDSNCQE 9083265
9085028 SPSEYIAAIQELSSLIVKRHHQPFLYLDFLYYCTADGRRFRKACDLVH 9085171
9085172 NFTDAVIRERRRTLSSQNLDEFLKSKTKSKTLDFIDVLLLAK 9085297
9085604 DEHGKELSDEDIRAEADTFMFG 9085669
9085859 GHDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW 9085990
9088714 DDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDVVLPDGRVIPK 9088845
9088918 GTDCVISIFGVHHNPEVWPDPE 9088983
9089148 VYDPFRFDPENPQKRSPLAFIPFSAGPR 9089231
9089587 RNCIGQTFAMREMKVALALTLLRFRVLPGDKEPRRKPELILRAEGGLWLRVEPLSKGTQ* 9089766
Cyp4f17 rat
Cyp4f18 frag.b mouse
GenEMBL ESTs AA716998 vu61b04.r1 AI006742 ua82h10.r1
frag. d AI006742 ua82h10.r1
PKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKXVVLA
frag. b AA716998 vu61b04.r1
LLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRD
LLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVIS
RISIFGTHHNPAVWPDPEV
Cyp4f18 fragments b and d 90% identical to 4F6, 89% to 4F4, 88% to 4F5, 87% to 4F1
complete sequence known but confidential (Henry Strobel)
Cyp4f18 mouse
GenEMBL NT_039466.1|Mm8_39506_30 - strand Chr 8
Note: not in the 4f gene cluster on chr 19
AF233647 AK007863 frag.b no UNIGENE entry EST AA716998 vu61b04.r1
138896 MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGL 138699
131761 IQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLA 131621
130374 PALVAPKDTVFYRFLKPWL 130318
130232 GDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMH 130104
127524 AKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQE 127402
125384 KPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDA
VIRERRRTLLDQGGVDVLKAKAKAKTLDFIDVLLLSK 125115
122460 DEHGKALSDEDIRAEADTFMFG 122395
122191 GHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEW 122060
119223 DDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPK 119092
119002 GVISRISIFGTHHNPAVWPDPE 118937
118372 VYDPFRFDADNVKGRSPLAFIPFSAGP 118292
117969 RNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLKVEPLSAGAQ 117793
Cyp4f18 rat
CYP4F19 rat
GenEMBL AI030199
probable rat ortholog to 4f17 81% identical
opposite end of this clone = BF554573 N-terminal
4f17 1 MLQLGLSWLGLGPGAAFPWQLLQLVGASLFLARILTWICAFYDNYCRLRCFPEPPS 56
MLQL LS LG GP PWQLL +VG SL LARIL WI AFYDNYCRLRCFP+PPS
4f19 1 MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS 56
4f17 53 EPPSRHWFWGHMSMVKNNEEGLQLLTERSHQFHDVHLCWIGPFYPILRLIHPKFIGSILQA 113
+P SRHWFWGH+++VKNNEEGLQLL E SHQF D+HLCWIG FYPILRLIHPKFIG ILQA
4F19 53 QPLSRHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA 113
* one amino acid difference in overlap
sequence = MLQLSLSCLGRGPVTVSPWQLLLVVGTSLLLARILGWISAFYDNYCRLRCFPQPPS
RHWFWGHLNLVKNNEEGLQLLAEMSHQFQDIHLCWIGIFYPILRLIHPKFIGPILQA
Cacgaggcattaacagagaagagcggaagtctctgggactcctgagaaaagg (start met)
atgctacagctgagcctg tcctgcctgg gccgggggcc agtgactgtc tccccatggc agcttctgct
ggtggttggg acctccttgc ttctggctcg aattctgggc tggatcagtg ctttctatga
caactactgc cgtctccgct gcttccctca gcccccttca
CGG CAC TGG TTT TGG GGT CAC TTG AAC TTG GTC AAG AAC AAT GAA GAA GGC CTG CAG TTG TTG GCT GAA ATG AGC CAC CAG TTC CAG GAT ATC CAC CTC TGT TGG ATT GGG ATC TTC TAC CCC ATC CTG AGG CTT ATC CAC CCC AAG TTT ATT GGC CCC ATA CTC CAG GCC
CYP4F20X starfish
Quoc Wu
Given its own subfamily renamed CYP4FA1
CYP4F21 sheep
AF246236
Johan Bylund
submitted to nomenclature committee 8/3/99
MLELSVSRLGFGLVAASPWLLLLVVGASWLLARVLAWTYTFYNN
CRLLQCFPQPPKQNWFFAHLYLVPPTEQGLRKSTQLAANYSHGYLIWFGPITPMIVFC
HPDMLRSIANASAAVAPKNMDFYKFLKPWLGDGLLLSAGDKWSRHRHLLTPTFHFNIL
KPYMKIFTKSTDIMHTKWERLITQGHTRLDMFEHLSLLTLDSLQKCVFSFDSNCQELS
SCRKPSKYITAILELSELVAKRNRQIFLHADFLYFLTLDGWRFLRACRLVHDFTDAVI
QERCRTLPENVDDFLKAKAKTKTLDFIDVLLLTKDEDGKRLSDEDIRAEADTFMFEGH
DTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRESKEIEWDNLAQLPFLTMCIKES
LRLHPPVTIISRCCTQDIVLPNGWVIPKGVICIIDIFGTHHNQSVWPDPEVYDPFRFD
QENIKGRSPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRFLPDKEEPRRKREL
ILRAEGGLWLQVEPLSASPQ
CYP4F22 human
GenEMBL AC011492
assembled gene 13 exons 114537-140651 66% to 4F3, 65% to 4F11, 63% to 4F2,
59% to 4F8, 64% to 4F12, 57% to AC011537 exact intron boundaries need checking no ESTs
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMVS
PNEAGLQDEKKVLDNMHHVLLVWMGPVLPLLVLVHPDYIKPLLGAS
AAIAPKDDLFYGFLKPWLG
DGLLLSKGDKWSRHRRLLTPAFHFDILKPYMKIFNQSADIMH
AKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSYNSNCQE
KMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTTEVIQERRR
ALRQQGAEAWLKAKQGKTLDFIDVLLLAR
DEDGKELSDEDIRAEADTFMFEG
HDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEW
DDLTQLPFTTMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPK
GIICLVSIYGTHHNPTVWPDSK
VYNPYRFDPDNPQQRSPLAYVPFSAGPR
NCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRPELILRTENGLWLKVEPLPPRA*
CYP4F22 Pan troglodytes (chimpanzee)
XM_512456.3
98% to human
MLPITDRLLHLLGLEKTAFRIYAVSTLLLFLLFFLFRLLLRFLR LCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPNEAGLQDEKKVLDNMHNVLLVWMGP VLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSRHRRLLT PAFHFDILKPYMKIFNQCTDIMHAKWRHLAEGSAVSLDMFEHISLMTLDSLQKCVFSH NSNCQEKMSDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVHHFTT EVIQERRWALRQQGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAEADTFMF EGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFTTMCI KESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYNPY RFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTRKVRR
KPELILRTENGLWLKVEPLPPRA
CYP4F22 Bos taurus (cow)
See cattle page for details
MLPITEQLLHLLGLEKTAFRLYAVSGLLLTLLFFLFRLLLQFLRLCWGFYITCRRLRCFPQPPRRNWLLGHLGM (0)
YLPNERGLQDEKKVLDDMHHVILVWLGPVLPLVVLVHPDYIKPLVGAS (1)
AAVAPKDDLFYGFLKPWL (1)
GDGLLLSRGDKWSRHRRLLTPAFHFDILKPYMKIFNQCADTMH (0)
AKWRGLAEGSEVSLDMFEHVSLMTLDCLQKCVFSYNSNCQE (2)
KMSDYISAIIELSALVVRRQYRLHHYLDFIYYRTADGRRFRQACDTVHGFTTEVIQERRR ALRQQGAEAWFKAKQGKTLDFIDVLLLAK (0)
DEDGKELSDEDIRAEADTFMFE (1)
GHDTTSSGLSWVLFNLAKYPEYQEKCREEIQEVMKGRELEELEWSGQ (2)
DDLTQLPFTTMCIKESLRQFPPVTLVSRRCTEDIKLPDGRIIPK (1)
GIICLVSIYGTHYNPAVWPDSK (0)
VYNPYRFDPDNPQQRSPLAYVPFSAGPR (2)
NCIGQSFAMAEMRVAVALTLLRFRLFLDRTRKVRRKPELILRTENGIWLKVEPLPPRA*
CYP4F23P human
GenEMBL AC011492
assembled gene 76% to 4F3, 76% to 4F8, 76% to 4F11, 73% to 4F2, 75% to 4F12,
77% to 4F11, 60% to other 4F on this accession no ESTs also on AD000091
MSLLSLSWLGLGPVAASPWLLLLLVGASWLLARVLAWTYAFYDNCHRLQCFQQPPKRNCF*GHLSLVS
GNEEDMRLMEDLGHYFRDVQLWWLGSFYPVLHLVHPTFTAPVLQAS AAVALKDMSFYGFLKPWLG
DGLLISAGDKWRWHRHLLTPAFHFKILKPYVKIFNESTNIMH
AKWQRLALEGSVRLEMFEHISLMTLDSLQKCIFSFDSNCQE
KPSEYIDAILELSALSLKRHQHIFLLTDFLYFLTPNGRRFCRACDIVHNFTDAVIQERRR
TLTSQGVDDFLQAKAKSKTLDFIDVLLLAK DENGKKLSDENIRAEADTFMSG
GHDTTASGLSWVLYNLARYPEYQEHCRQEVQELLKNGDPKEIEW
DDLAQLPFLTMCLKESLRLHSPVSRIHRCCPQDGVLPDGRVIPK GNTCTISIFGIHHNPSVWPDPEV
YDPFRFDPENLQKTSPLAFIPFSAVPR
NCIGQTFAMAEMKVVLALTLLRFRVLPDHAEPRRKLELIVRAEDGLWLRVEPLSADLQ*
CYP4F24P human
GenEMBL AC011537.4
77% to 4F11 missing last exon two in frame stops and a gap.
24346 MPQLSLSWLGLGQVAAFPWLLLLLAGASRLLAGFLAWTYAFYDNCRRLQYFPQPPKQKWF 24167
24166 WGQPGX 24152
6633 IIATEEGLKNLTQMSATYPQGFRIWLGPIFPFIVLCHPDIVRSITNAS 6788
8837 AAIAPKDDLSIRFLKPWLGEGILLSGGDK 9016
9017 WSRHRRMLTPAFHFNILKPYIKIFNRSVNIMH 9112
11018 DKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQE 11140
11921 RPSEYIATILELSALVEKRNQHILQHMDFLYYLSHDGWRFRRACRLVHDFTDAVIQERRH 12100
12101 TLPTQGI 12121
12115 CDFLKNKAKS*TLDFIDVLLLSKXXXXXXXXXXXXXXXXXXXXXX 12189
13460 GHDTTASGLSWVLYNLARHPEYQEHCRQEVQELLKDRDPKEIEWX 13591
21804 DLAQLPFLTMCVKESLRLHPPVPYTSRHRIWDIVLPDGRVIPK 21932
22019 GIICIINIIGIHHNPTV*PDPEV 22165
22263 YNPFRFNSENSKERSPLAFIPFSAGPR 22361
CYP4F25P human = CYP4F-se1[6:8]
GenEMBL AC018949
62% to 4F3 pseudogene
95242 LWRCFLSPTSPCRNPSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDL 95066
95065 VHNF 95054
95052 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 94936
GenEMBL NT_078056.1|Hs9_78125 chromosome
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 65960 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 66106
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 66108 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 66224
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 66811 GYDSTASGLYWILVPLRRHP 66870
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 66878 GVLPPRGARVLRDGNSEDIEW 66940
CYP4F26P Human = CYP4F-se2[6]
GenEMBL AL139008
Homo sapiens chromosome 9 clone RP11-255A11 81% TO CYP4F-se1[6:8]
NT_008413.15|Hs9_8570 Homo sapiens chromosome 9
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
S+Y+AT+ EL ALIV*WHQQICLCMDFLYY PEG CFCRA DLVHNF
Sbjct: 33593291 SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF 33593434
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQ V D LK +ATFKT DF DALVL K
Sbjct: 33593436 DTIILEQHCTLTSQSV-DILKARATFKTLDFIDALVLSK 33593549
CYP4F27P human = CYP4F-se3[6:7:8]
GenEMBL AC018804.2
Chr2:130805998-130806965 (-) strand
Homo sapiens clone RP11-397H17 62% TO CYPF25P
New name/synonym = CYP4F-se3[6:7:8]
because the HGNC has strict rules for gene names,
The old names (CYP3A51P, etc.) are being used by the HGNC
These will be synonyms.
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171
CYP4F28 Fugu rubripes (pufferfish)
No accession number
Scaffold_2425
76% to 4F7
8381 MSVLQLALSWTSVCPLLAVLAAAPVALLTFWTAKLLVRHAWYTHRMACFSKPHARSWLLGHLGQ 8190 (0)
7561 MQSTEEGLLQVDELVQMFTYCCSWFIGPFYHLVRVFHPDYVKPLLMAP 7418 (1)
7238 ASITVKDELIYDHLRPWL 7185 (1)
7049 GNSLLLSNGEAWSRRRRLLTPAFHFDILKNYVTKFNTSTNTLH 6921 (0)
6727 DKWHRLLVEGTTNIEVFEHFTLMTLDSLLKCAFSYDSDCQQ 6605 (2)
6527 SSSEYASAIIELSDLIIERRQRILHHWDWIYWRTQQGKRFKKALSIVHK 6381 (2)
6307 FTRDVVQKRLALISQKGVAELAAHRKRDFVDIILLTK 6197 (0)
6115 DEDGKGLTDEELQAEANTFMFA 6050 (1)
5813 GHDTTASAICWSLYNLAHHNHYQEQCRQEVMDLMEGRDVDEIKW 5682 (2)
5607 EDLSSLPFTTMCIRESLRLHSPVQAVTRRYIQDVKLPGERTVPK 5476 (1)
5248 GAICLVSIYGTHHNPAVWTNPH 5183 (0)
5101 DFDPLRFDPKNQEGLSSHAFIPFSSGPR 5018 (2)
4948 NCIGQKFALAELRVVVALTLLRFRLLPGNDPKRETPFEKVRRLPQLVLRAEGGLWLQIKPVTQTQ* 4751
CYP4F28 Tetraodon nigroviridis (freshwater puffer)
84% to fugu CYP4F28 (ortholog)
MTVLQLLAALGAGLCAGLCALLAFWTAKLLVRHAWYTHRMSCFSRPHARSWLLGHLGQ (0)
MQSTEEGLLQVEELVQMFTYCCSWFIGPFYHLLRVFHPDYVKPLLTAS (1)
ASITVKDELIYGHLRPWL (1)
GRSLLLSNGEVWLRKRRLLTPAFHFDILKNYVAKFNTSTNTMH (0)
DKWRRLAAEGPTHVEAFEDVTLMTLDSLLKCAFSYDSDCQQ (2)
SSSEYASAIVQLSDLIIERRQRILHHWDWIYWRTRQGKRFQQALSIVHK (2)
FTRDVVQERRTLIGQKGEMAAQGKKDFVDIILLSK (0)
DEDGKGLTDEEIQAEANTFMFA (1)
GHDTTASAICWSLYNLARHDHYQEKCRKEVMDLMEGRDVHEINW (2)
EDLSSLPFTTMCIRESLRLHSPVQAVTRRYLQDVELPGGHTVPE (1)
GAICLVSIYGTHHNPAVWTNPH (0)
DFDPLRFDPTNQKGLSSHAFIPFSSGPR (2)
NCIGQKFALAELRVVVALTLLRFRLSPGRDPRLGTTSGKVRRLPQLVLRAEGGLWLQVEPVTPAQ*
CYP4F29P human = CYP4F-se4[6:7:8]
AL109748 chr 21
designated CYP4F3LP pseudogene Nature 405, 311-319 2000
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW
CYP4F30P human = CYP4F-se9[6:7:8]
NT_022140.9|Hs2_22296 Homo sapiens chromosome 2
270169 RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLTSQGVDDFLKAKATFKA 269990
269989 SDFIDALVLSK 269957
CYP4F31P human = CYP4F-se10[6:7:8]
NT_019306.9|Hs2_19462 Homo sapiens chromosome 2
2940797 PEG*CFYKACDLVHNF 2940844
CYP4F32P human = CYP4F-se5[6:8]
NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to CYP4F-se1[6:8]
New name = CYP4F-se5[6:8]
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
NT_022300.8|Hs2_22456 chromosome 2 88% to 4F25P
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845
CYP4F33P human = CYP4F-se6[6]
NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 genomic contig
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTLT 61
S+Y+AT+ EL ALIV*WHQQICLC DFLYY PEG CFC DTIILE+ CTLT
Sbjct: 38532567 SDYVATILELHALIV*WHQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLT 38532388
Query: 62 SQGVHDFLKTKATFKTWDFSDALVLGK 88
SQGV D LK KATFKT DF DALV K
Sbjct: 38532387 SQGV-DVLKAKATFKTLDFIDALVPSK 38532310
CYP4F34P human = CYP4F-se7[6:7:8]
NT_009799.9|Hs13_9956 Homo sapiens chromosome 13
343178 DTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
NT_009799.9|Hs13_9956 chromosome 13 4F pseudogene 78% to 4F27P
Old name = 4F34P
343270 HQQICLCMDFLYYXX 343232
343226 PDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
NT_009799.12|Hs13_9956 Homo sapiens chromosome 13 genomic contig
Length = 12392145
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 33
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
Sbjct: 296823 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 296725
Query: 32 PFPEG*CFCRACDLVHNFDTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
P P+G DTIILEQ CTLTSQGVHDFLK KATFKT DFSDAL+LGK
Sbjct: 296731 PIPDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 296561
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELSDEDI*MEA IFMST
Sbjct: 296237 QDENGKELSDEDI*MEADIFMST 296169
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRD NPEDIEW
Sbjct: 295991 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDRNPEDIEW 295869
CYP4F35P human = CYP4F-se8[6:7:8]
NT_010859.8|Hs18_11016 chromosome 18 4F pseudogene 84% to 4F12
chr18p11.21 14328070-14328279 + strand build 33
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
NT_010859.12|Hs18_11016 Homo sapiens chromosome 18 Length = 14719514
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTL 60
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF G DTIILEQ CTL
Sbjct: 14328016 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTL 14328195
Query: 61 TSQGVHDFLKTKATFKTWDFSDALVLGK 88
TSQGVHDFLK KATFKTWDFSDALVLGK
Sbjct: 14328196 TSQGVHDFLKAKATFKTWDFSDALVLGK 14328279
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELS+EDI*MEAGIFMST
Sbjct: 14328531 QDENGKELSEEDI*MEAGIFMST 14328599
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GY+STATGLY*ILCNLRRHPGVMPS GARVLRD NPEDIEW
Sbjct: 14328777 GYESTATGLY*ILCNLRRHPGVMPSRGARVLRDRNPEDIEW 14328899
CYP4F36P human = CYP4F2-de12b
NT_011281.4|Hs19_11438 chromosome lone last exon 75% TO 4F11
66609 ICMGQVFAVAEMKVVLALTLLGFRFLRHHMEPGRKPELIMHAEGGL*LLVEPLS 66448
Cyp4f37 mouse
AC073754 comp(28012-47256) also NT_039649.1
93% identical to 4f16, duplicate exon 6, fs in exon 7
MLRLSVSGLDLGSVVTLSWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQPPKRNWFLGHLGM
IEHNEEGMQLMTEAGQTYRDVHLCWLGPVIPVLRIVDPAFVAPLLLA TALVAPKDTTFHTFVKPWL
GDGLFLNSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMH
AKWKHLSSEGSARLEMFEHISLMTLDSLQKCLFGFDSNCQE
SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHTADGRRFRKACDLVHNFTDAVIR
ERRHTLSSQNHDEFLKSKTKSKTLDFIDVLLLAK
DEHGKELSDEDIRAEADTFMFGG
HDTTASALSWILYNLARHPEYQERCRQEVQELLRGREPQEIEW
DDLAQLPFLTMCIKESLRLHPPVIDLLRRCTRDIVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VYDPFRFDPENAHKRPPLAFIPFSAGP
RNCIGQTFAMNEMMVALALTLLRFRILPDDKEPRRKPEIILRAEGGLWLRVEPLS
Cyp4f37-ie6b mouse
GenEMBL NT_039649.1 duplicate exon 6, incomplete
x in Figure 4B Nelson et al. Pharmacogenetics 14, 1-18 2004.
9192951 SPSEYISAILELSSLVIKRSHQLFLFVDFLYYHPADGR 9193064
9193067 FRKACD 9193084
>Cyp4f37-de1b mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
exon 1 22-60
z in Figure 4D Nelson et al. Pharmacogenetics 14, 1-18 2004.
9142319 LLPFMAS*PLGRILAWTHFFYEVCACLICFPQAPKQNWF 9142435
>Cyp4f37-de7b8b mouse
GenEMBL NT_039649.1|Mm17_39689_30 + strand
exons 7, 8
y in Figure 4D Nelson et al. Pharmacogenetics 14, 1-18 2004.
9166323 DERGKELSDEDIWAEAYTFVFGR 9166391
9168358 XXXXXXALSWILYNLVRHPEYPECCLWEVQELLRDLNHEEIEX 9168465
Cyp4f37 rat
Cyp4f38-ps mouse
AC073754 comp(9555-20475) also NT_039649.1
partial pseudogene 52% to 4f14
AHILIQVYAAYGNYPHIPKWNWLMGHVSM
PQRRARRMLLNW*GNYP*GFIL*MIPLVSILKPCHPGIAKSV
VSAGDKWSHHCHMLTPAFHFNILKLYVKIFNDSTNIVH
LNISDHVILMTLGNFQKCIFSFDSNCQD
AIMELSMLISRRNKEPLLHMDLLGHLTPDGMCCCKACSMMHGLDDAVI
QERGHILSRQGLDGFFKDKVKFKPLNFIAVLLLTK
DDMSQLPFLTMCISLWLHPPDLLISYYCI*DVVLPDGWIIPKG
Cyp4f39 mouse
AC073754 range 185296-209241, also NT_039649.1
minus strand 62% to 4F14
MLPLTDYLLQLLGLEKTAFRVYV
VSALLLLVLFFFFRLLVRAFKLFSDFRITCRKLSCFPEPPGRHWLLGHMSMVS
PNEKGLQNEKKVLDTMHHIILAWVGPFLPLLVLVHPDYIKPVLGAS
AAIAPKDEFFYSFLKPWLG
DGLLISKGNKWSRHRRLLTPAFHFDILKPYMKIFNQCTNIMH
AKWRRHLAEGSVTSFDMFEHISLMTLDSLQKCVFSYNSDCQE
SMSDYISSIIELSALVVRRQYRLHHYLDFMYYLTADGRRFRQACDTVHNFTTEVI
QERRQALRQQGAEAWLKAKQGKTLDFIDVLLLAK
DEEGKELSDEDIRAEADTFMFEG
HDTTSSGLSWALFNLAKYPEYQEKCREEIQEVMKGRELEELDW
DDLTQLPFTTMCIKESLRQFPPVTLISRRCTEDIKLPDGRVIPK
GIICLVSIYGTHHNPIVWPDSK
VYNPYRFDPDTPQQRSPLAFVPFSAGP
RNCIGQSFAMAEMRVVVALTLLRFRLSVDRTHKVRRKPELILRTENGLWLNVEPLPSRA*
Cyp4f39 rat
Cyp4f40 mouse
AC073754 range <1-3688, also NT_039649.1
minus strand two N-terminal exons no ESTs
continues on AC073720 comp(118300-137027) 79% to 4F14
MRYLDLSWLGLGPMSASPWLLFFLVGISWFLARFLTQLYTLYAKCQRLCGFPQPPKKNWFWGHLGMVS
PTEEGMKQVTELVTTYPQGFMTWLGPIVPLITLCHPDIIRSVLSAS
SAAVAPKDDIFYSFLKPWL
GDGLLVSAGDKWNRHRRMLTPAFHFNILKPYVKIFNDSTNIMH
AKWLRLASGGSTRLNMFENISLMTLDTLQKCVFSFNSNCQE
KPSQYIAAILELSTLAVKRNEQLLMHVDLLYRLTPDGMRFYKACRLVHDF
TDAVIQERRRTLLKHGGDDIIKAKAKSKTLDFIDVLLLTK
DEDGKELSDEDIRAEADTFMFRG
HDTTASGLSWILYNLARHPEHQERCRQEVQELLRDRDPKEIEW
DDLAQLPFLTMCIKESLRLHPPVTMVSRCCTQDISLPDGRIIPK
GVICIINIFGTHHNPTVWRDPE
VYDPFRFDPENIQARSPLSFIPFSAGP
RNCIGQTFAMSEMKVALALTLLRFRILPDDKEPRRKPELILRAEGGLWLRVEPLSTQA
Cyp4f40 rat
Cyp4f41-ps mouse
GenEMBL NT_039649.1|Mm17_39689_30 - strand
Pseudogene exons 5,6,9,10,12 189-216
9523155 NKWQCLTFESSASL 9523114
9523111 ALFEHMNLTTVDSLQKCVFSFHSNCQE 9523031
9521583 SNSKYIAAILELISFNSTSPSWMWTSCTNYLSVDG*CFHKACNLVDSFTDVVIT 9521422
9521421 TEGPCNLNTQGVDEFLKAKAKAKTLDFIDVLLKTR 9521317
9518053 NDLTQLPFLTMSMKESLRLHPPGSMISLCCIQDILLLDDLVISS 9517922
9517838 GHVC 9517827
9517828 VTSIFRSHHNPSVWPDPE 9517775
9517097 RNCIGLTFGHECNEDDDGADADAARFCVLPGDKGPRRLSALMLRTEGGLWLQVELLT 9516927
CYP4F42a Xenopus laevis (African clawed frog)
NM_001172179
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
64% to 4F22 in humans (full length)
MLPFLDHFLDSLNLSHSTFRVYIFYAVILFFSLIMFRTILKMVT
YIYAYIINARRLRCFPEPPRRSWLLGHLGLFMPTEEGLTEVSDAISSFRKTFLTWMGP
ISLVSVFHPDTVKPIVAASAAIAPKDDLFYGFLRPWLGDGLLLSHGEKWGRHRRLLTP
AFHFDILKSYVKIFNQSTDIMLAKWRRMTVEGPVSLDMFEHISLMTLDTLLKCTFSYD
SDCQEKPSDYIAAIYELSSLMVKREHYLPHHLDFIYNLSSNGRNFRQACKKVHEFTAG
VVQQRQKALKEKGMEEWIKSKQGKTKDFIDILLLSKVEDGNQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLARHPEYQEKCRKEIIELLEGKILKHLEWDELSQLPFTTMCIK
ESLRLHPPVTAVSRRCTEDIKLPDGKVIPKGNTCLISIYGTHHNPEIWPNPQVYDPYR
FDPENVQERSSHAFVPFSAGPRNCIGQNFAMAEMKIVLALILYKFHVRLDETKAVRRK
PELILRAENGLWLQVEELKR
CYP4F42b Xenopus laevis (African clawed frog)
SwissProt A0AUU0
86% to CYP4F42a presumed ohnolog due to genome duplication
MLQFLDHFLDSLNPSHTTFRVYIFAAIILIFSLIIFRTILKMVKFIYAYIINARRLRCF
PEPPRRSWLLGHMGLIKNTEEGLLVVDSLVKTYIYACSWWFSLCYPIVRLFHPSSIKPI
LQVSAAIAQKDELFYGFLRPWLGDGLLLSHGEKWGRHRRLLTPAFHFDILKNYVKIFNQ
STDIMLAKWRRLAVEGPVSLDMFEHVSLMTLDTLLKCTFSYDSDCQEKPSDYITAIYEL
SSLVVKREHYLPHHFDFIYNLSSNGRKFRLACKKVHKFTAGVVQQRKKALQETGAEEWI
KSKQGKTKDFIDILLLSKDEDGNQLSDEDMRAEVDTFMFEGHDTTASGLSWILYNLARH
PEYQEKCRKEITELLEGKDTKHLEWDELSQLPFTTMCIKESLRLYPPVTAISRRCTEDI
KLPDGKVIPKGNSCLISIYGTHHNPEVWPNPQVYDPYRFDPEKLQERSAHAFVPFSAGP
RNCIGQNFAMAEMKIVLALTLYNFHVRLDETKPVRRKPELILRAENGLWLQVEELKS
CYP4F43P rat
pseudogene chr7 (+) strand exons 4, 5, 9, 10, 11, 12
between 4F37 and 4F40
13179984 RDGVFLISFDKWNHHHCLLTPAFHFDNLVL 13180073
*VKIFNQSVNIIH
13181413 VSFLKAKWKCLFSEGSACLEIFENLTTLDSLQKCLFSLDSNCQE 13181544
13207589 NDLAQLPFLTMCIKASLQLYPQDTNLICSCT 13207681
*DILLPDG*VIPK
XXXXXXXXXGVHHSPSVWTDPX
13208327 VYYPFPFDSKNPQKISPLAFMPFSVGP 13208407
13208782 RNCKRQTYPMSERKVALVLKLLHFHTIPGEIDPPRQPELILSLEGRLWLLKESLSVG 13208952
CYP4F44P human = CYP4F-se12[6:8] name conflict with rat
NT_008251.13|Hs8_8408 Homo sapiens chromosome 8 genomic contig
Length = 5847381
chr8P11.1 43132635-43132941 + STRAND BUILD 33
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PS+YIAT+ ELSALI+* QQI L DFLYY EG CFCRAC +VHNF
Sbjct: 5439042 PSDYIATILELSALIM*RQQQIFLHRDFLYYVTAEGWCFCRACVVVHNF 5439188
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQGV++FLK ATFKT DF D LVL K
Sbjct: 5439190 DTIILEQHCTLTSQGVNNFLKVTATFKTLDFIDVLVLDK 5439306
Query: 111 GYDSTATGLY*IL 123
GYDSTA+GL+ +L
Sbjct: 5439892 GYDSTASGLFWVL 5439930
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P+ GA VLRDH+PEDIEW
Sbjct: 5439959 GVLPALGAGVLRDHSPEDIEW 5440021
CYP4F44P rat (name conflict with human CYP4F44P)
pseudogene MISSING EXON 1 AND HALF OF EXON 2 90% to 4f16
between 4F37 and 4F40
13215861 LGPVIPVLRLVDPAFVAPLLQAP 13215929
13219942 ALVAPKDMNFYGFLKPWL 13219995
13220082 GDGLLLSSGDKWNRHRXLTPAFHFDILKPYVKIFNQSVNIMH 13220206
13227610 VKWKHLCVEGSAHLEMFENISLMTLDSLQKCLFGFDSNCQE 13227732
13228571 SPSEYISAILELSSLTIKRSYQLFLYLDFLYYRTADGRRFRKAC
DLVHSFTDAVIRERRRLLSSQGVDEFLESKTKSKSKTLDFIDVLLLAK 13228846
13230087 DEHGKELSDEDIRAEADTFMFG 13230152
13230344 GHDTTASTLSWILYNLARHPEYQESCLQEVWELLRDREPEEIEW 13230475
13239583 DDLAQLPFLTMCIKESLRLHPPAVDLLRRCTQDIVLPDGRVIPK 13239714
13239826 GNICVISIFGIHHNPSVWPDPE 13239891
13240051 VYDPFRFDPESRQKRSPLSFIPFSAGP 13240131
13240378 RNCIGQTFAMNEMKVAVALTLLRFRLLPDDKEPRRKPEIILRAEGGLRLLVEPLSGGA* 13240554
CYP4F45P human = CYP4F-se13[6:8] (name conflict with macaque)
AC018949 62% to 4F3 pseudogene
found in two places 100% match
CYP4F-se1[6:8] chr9p11.2 43742181-43742487 (4F25P) + strand build 33
CYP4F-se13[6:8] chr9q13 63753376-63753682 (4F45P) + strand build 33
NT_078070.1|Hs9_78139 Homo sapiens chromosome 9 genomic contig
Length = 423701
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 34719 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 34865
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 34867 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 34983
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 35569 GYDSTASGLYWILVPLRRHP 35628
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 35636 GVLPPRGARVLRDGNSEDIEW 35698
CYP4F45/4F2 Macaca fasicularis (cynomolgus monkey)
DQ074798
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP4F2#1
87% to 4F11 human, 88% to 4F2 and 87% to 4F3
needs a separate name. Cannot identify the ortholog without map data
based on the rhesus genome this is probably the CYP4F2 ortholog
MSQLSLSWLGLGPVAVSPWLLLLLVGTSWLLARVLAWTYTFYDN
SRRLRGFPQPPKRNWFWGHQGMVKSTEEGMRVLTQLVATYPQGFRVWMGPVFPLLSLC
HPDIIRSVINASAAIVPKDKLFYRFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNIL
KPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKP
SEYIAAILELSALVSKRHQQFLLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRR
TLPSQGVEDFLQAKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTA
SGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLH
PPVPVISRRVTQDIVLPDGRVIPKGITCLLSVFGTHHNPTVWPDPEVYDPFRFDPENI
KERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRA
EGGLWLRVEPLS
CYP4F46 Bos taurus (cow)
See cattle page for details
MLELSMSRLGLGLVAASPWLLLLVVGASWLLAHILAWTYTFFNNCRLLQCFPQPPKLNWFFAHLYL (0)
VPMTEQGLRKLTQLAANYSHGYMIWFGPITLMIVFCHPDMLRSITNAS
AAVAPKDMDFYNFLKPWLG
DGLLLSAGDKWSRHRCMLTPTFHFNILKPYMKIFTKSTDIMH
TNWECLVTQGHTRLDMFEHVSLLTLDSLQKCVFSFDSNCQE
KPSEYITTIFELCELAAKRNKQICLHTDFLYFLTLDGWHFRRACRLVHNFTDSIIQEQRCTLPSENI
DDFFKAKVKTKTLDFIDVLLLSK
DEDGKGLSDEE
IRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCGQEVKELLRDCESKEIEW
DDLAHLPFLTMCIKESPRLHPPVTFIFRYCTQDIVLPDGRVIPK
GVVCLIDIFGTHHNPSVWPDPE
VYDPFRFDPENIKGRSPLAFIPFSAGSR
NCIGQTFAMTEMNVVLALTLLRFRFRPDKEEPRRKPELILRAEGGLWLQVELLSAGPQ*
CYP4F47 Bos taurus (cow)
See cattle page for details
MLELSLSWLGLRPVAASPWLLLVLVGASWILAHVLAWTYTFYNNSRHLQCFPQPPKRNWFLGHMGQYPP
TEKGLRDFTQLVANYPQGFRICLGPAIPIIIFCHPDMIRIVANAS
AAAAPKDVIFYDFLKPWLG
DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFTKSADIMH
AKWQRLITEGHTHLDMFEHISLMTLDSLQKCVFSYDSNCQE
KPNEYIASILELSALVAKRNQQIFLHMDFLYFLTPDWRRFRRACRLVHDFTDAVIQERRHTLPSEGT
DDFLKAKVKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWVLYNLAKHPEYQERCRQEVQDLLRDRESKEIEW
DDLAQLPFLTMCIKESLRLHPPVSVISRRYAQDTLLPDGRVIPK
GVICLINIIGTHHNPSVWPDPE
VYDPFRFEPENIKGRSPLAFIPFSVGPR
NCIGQTFAMTEMKVVLALTLLRFRVLPGEEPRRKPELILRAEGGLWLRVEPLSADQ
CYP4F48 Bos taurus (cow)
See cattle page for details
MLELSLSRLGLGPLAASPWLLPLLAGVSWILARVLAWTYTFYNNSRRLRCFLQPPKPNWFLGHMNL
VPSTEQGLIYFTQMAANYPRGYLIWFGPIIPMVIFCHPDMLRSITNAS
AAIAPKDMQFYGTLKPWLG
DGLLLSAGDKWSSHRRMLTPAFHFNILKPYIKIFTKSAEIMH
AKWEHLITEGHTHLDMFEHISLLTLDNLQKCVFSFDSNCQE
KPSEYIAAILELSALVSKRNQQLFLYMDFLYYLTSDGQRFRNACRLVHDFTDAVIQERRRTLPKENI
DDFLKAKAKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCRQEVQDLLRDRESKEIEW
DDLAQLPFLTMCIKESLRLHPPVTSISRRCTQDIVLPDGRVIPK
GVVCLIDIFGTHHNPSVWQDPE
VYDPFRFDPENIKGRSPLAFIPFSAGPR
NCIGQTFAMTEMKVILALTLLRFRVLPDKEPCRKPELILRTEGGLWLRVEPLSAGQQ*
CYP4F49 Bos taurus (cow)
See cattle page for details
MLELSLSWLGLGPVAASPWLLLLFTGASWLLARILAWTYTFYNNSRRLQCFPQPPKRNWFLGHLGL
VPPTEQGMSKLTELVAKYSQGFRIWMGPITPIIVFCHPDLIRIVANAS
AAVAPKDVIFYEVLKPWLG
DGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFTKSTDIMH
AKWQHLIKEGHTHLDMFEHISLMTLDSLQKCIFSYDSNCQE
KPSEYIAAILELSALVAKRHQEIFLHMDFLYYLTPDGRRFRRACRLVHDFTDAVIQERHRTLPSESI
DDFLKAKAKTKTLDFIDVLLLTK
DEDGKGLSDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHKEYQERCRQEVQELLKDREPKNIEW
DDLAQLPFLTMCIKESLRLHPPVSVISRRCTQDTVLPDGRVIPK
GVICLISIFGTHHNPSVWPDPE
VFDPFRFDPENIKGRSPVAFVPFSVGPR
NCIGQTFAMTEMKVVLALTLLRFRVLPDKEEPRRKPELILRAEGGLWLRVEPLSTGQQ*
CYP4F50 Bos taurus (cow)
See cattle page for details
MLELSLSWLGLGPVAASPWLLLLLVGASWILARILAWIYAFYDNCCRLRCFPQPPKRSWFWGHLGL
AQSNEESMRLVEELGHYFRDVHLWWMGPFFPILRLVHPNFVAPLLQAS
ATIIPKDMFFYSFLKPWLG
DGLLLSAGDKWSSHRRLLTPAFHFEILKPYMKIFNKSADIMH
AKWQRLALEGSTRLDMFEHISLMTLDSLQKCVFSYDSNCQE
KPSEYIAAILELSALVMKRIKHIFLHVDFLYYLTRDGQRFYRACRLVHDFTDAIIQKRRRTLISQGS
QEFLKTKTKAKTLDFIDVLLLAK
DEDGKGLPDEDIRAEADTFMFE
GHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDREPKEIEW
EDLAQLPFLTMCIKESLRLHPPVAVISRLCTHDVVLPDGRVIPK
GNICVISIFGIHHNPSVWPDPE
VFNPFRFDPEAPKRSPLAFIPFSAGPR
NCIGQTFAMNEMKVALALTLLRFRILPDEEEPRRKPELILRAEGGLWLQVEPLNTGQ*
CYP4F51 Danio rerio (zebrafish)
See zebrafish page for seq
CYP4F52 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
77% to human 4F11, 81% to 4F49 cow
only 1 aa diff to AK233364 complete seq.
partial seq.
CYP4F52 Sus scrofa (pig)
AK233364
2 aa diffs to AK233483
MLQLSLSWLGLGPVEASPWLLLLLVGASWLLARVLVWTCTSLDNV
RRLRGFPQPPKPNWLLGHMGQVPPTEEGMTKLTQMMNTYPNGFMIWMGPITPIIVLCHPD
LIRTMANASAAVAPKDVVFYDFLKPWLGDGLLLSAGDKWSSHRRMLTPAFHFNILKPYMK
IFNDSVNVMHAKWQRLVTEGHNRLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYIAAI
LELSALVAKRHQQIFLHLDFLYYLTPDGWRFHKACRLVHDFTDAVIQERRNTLPTEGIDD
FLKAKAKAKTLDFIDVLLLTKDEDGKGLSDEDIRAEADTFMFEGHDTTASGLSWVLYNLA
KHPEYQERCRQEVHELLRDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRRCTQD
IVLPDGRIIPKGVICLISIFGTHHNPLVWQDPEVYDPFRFDPENIKERSPLAFIPFSAGP
RNCIGQTFAMTEMKVVLALTLLRFRVLPVEEEPRRKPELILRAEGGLWLRVEPLSASPQ*
CYP4F53 pig
AK230568
85% to AK233364
MLQLSLSKMGLWLMAASPWLLLLLVGASWLLVQVLVW
TYTSYDNARRLRGFPQPPKRNWFLGHLGLIQSSEEGLLYTQDLASTYGDVCCWWVGPWHA
VIRIFHPTYIKPVLFAPAAIAPKASVFYDFLKPWLGDGLLLSAGDKWSSHHRMLTPAFHF
NILKLYMKNFNDSVNVMHAKWQHLVTEGHNRLDMFEHISLMTLDSLLKCVFSFHSNCQEK
PSQYIAAIVELSALVAKRHQQIFLHLDFLYYLTPDGWRFHKACRLVHDFTDAVIQERRNT
LPTEGIDDFLKAKDKAKTLDFIDVLLLTKDEDGKRLSDEDIRAEADTIMFGDHDTTASGL
SWVLYNLAKHPEYQECCRQEVHELLRDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVTV
ISRRCAQDIVLPDGRIIPKGVICLISIFGTHHNPSVWPDPEVYDPFRFDPENIKGRSPLA
FIPFSAGPRNCIGQTFAMTEMKVVLALTLLHFRVLPDKEEPRRKPELILRAEGGLWLQLE
PLSAGQQ*
CYP4F54 pig
AK238099
95% to AK233210 22 diffs
MLQLSLSWLGPGPVSASPWLLLQLVGATWLLSRILS
WIYDFYDNCCRLRCFPQPPKRNWFWGHWDLAKSNEEGLQLIEDMGRLFCDVYLWWLGPFY
PILRLVHPNFVAPLLQAPATIIPKDMLFYSFLKPWLGVGLLLSAGEKWSHQRRLLTPAFH
FDILKSYVKIFNRSADIMHAKWQRLASEGHTRLDMFEHISLMTLDSLQKCVFSFDSNCQE
KPSEYITAILALSALVIKRCEQIFLHKDFLYYLTPEGRRFRKACRLVHDFTDAVIQERRC
TLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIRAEADTFMFAGHDTTASG
LSWVLYNLAKHPEYQERCRKEVQELLRDREPKEIEWDELAQLPFLTMCIKESLRLHPPVP
GISRCCAQDVVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYNPFRFDPESPQKRSPL
AFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPRRKPEIVLRAEGGLWLRV
EPLRGGQQ*
CYP4F55 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
Three partial sequences called CYP4F6v1a,
CYP4F6v1b and CYP4F6v2 each have only 1 or 2
Amino acid diffs to the complete seq AK233210
These all appear to be from a single gene
CYP4F55v1 Sus scrofa (pig)
AK233210
5 aa diffs to AK239242 allele?
MLQLSLSWLGLGPVSASPWLLLQLVGATWLLSQ
ILSWIYDFYDNCCRLRCFPQPPKRNWFWGHRDLAKSNEECLQLMEDVGHYFHDVYLWWLG
PFYPILRLVHPNFVAPLLQAPATIIHKDMFLYIFLKPWLGVGLLLSAGEKWSHQRRLLTP
AFHFDILKSYVKIFNRSADIMHAKWQRLASEGHTRLDMFEHISLMTLDSLQKCVFSFDSN
CQEKPSEYIAAISELSALVTKRNEQIFLHKDFLYYLTPEGRRFRKACRLVHDFTDAVIQE
RRRTLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIRAEADTFMFAGHDTT
ASGLSWVLYNLAKHPEYQERCRQEVQELLRDREPKEIEWDELAQLPFLTMCIKESLRLHP
PVTGISRCCTQDVVLPDGRVIPKGNICVISIFGIHHNPSVWPDPEVYNPFRFDPESPQKR
SPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPRRKPEIVLRAEGGLW
LRVEPLRGGQQ*
CYP4F55v2 Sus scrofa (pig)
AK239242, AK232426
5 aa diffs to AK233210
MLQLSLSWLGLGPVSASPW
LLLQLVGATWLLSRILSWIYDFYDNCCRLRCFPQPPKRNWFWGHQDLAKSNEECLQLMED
VGHYFHDVYLWWLGPFYPILRLVHPNFVAPLLQAPATIIHKDMFLYIFLKPWLGVGLLLS
AGEKWSHQRRLLTPAFHFDILKSYVKIFNRSADIMHAKWQHLASEGHTRLDMFEHISLMT
LDSLQKCVFSFDSNCQEKPSEYIAAISELSALVTKRNEQIFLHKDFLYYLTPEGRRFRKA
CRLVHDFTDAVIQERRRTLISQGSQDFLRAKAKAKTLDFIDVLLLAKDEDGKGLSDEDIQ
AEADTFMFAGHDTTASGLSWVLYNLAKHPEYQERCRQEVQELLRDREPKEIEWDELAQLP
FLTMCIKESLRLHPPVTGISRCCTQDVVLPDGRIIPKGNICVISIFGIHHNPSVWPDPEV
YNPFRFDPESPQKRSPLAFIPFSAGPRNCIGQTFAMTEMKVVLALTLLRFRVLPDEEEPR
RKPEIVLRAEGGLWLRVEPLRGGQQ*
CYP4F56 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
84% to 4F3 human, 88% to 4F49 cow, 94% to CYP4F52
15 aa diff to AK233364 CYP4F52 complete seq.
partial seq.
CYP4F57v1 Xenopus tropicalis (Western clawed frog)
AL648475.2, CF786466.1, AL896688.2
NM_001016020.2
62% to 4F22, 1aa different to NM_001015770
90% to NM_001015810, same as DT404766.1
87% to CYP4F42 X. laevis
CYP4F57 and CYP4F58 are adjacent and seem to be co-orthologs
of CYP4F42 Xenopus laevis
MLPFLDHFLDSLNMSRTSFRVYIFAAVILMFCLIMCRTIFKMAI
YIYAYIINARRLRCFPEPPRRSWLLGHLGMFMPTEEGLTEISSAICNLRRTLLTWLGP
IPEVSLVHPDTVKPVVAASAAIAPKDELFYGFLRPWLGDGLLLSRGEKWGQHRRLLTP
AFHFDILKNYVKIFNQSTDIMLAKWRRLTAEGPVSLDMFEHVSLMTLDTLLKCTFSYD
SDCQEKPSDYISAIYELSSLVVKREHYLPHHFDFIYNLSSNGRKFRQACKTVHEFTAG
VVQQRKKALQEKGMEEWIKSKQGKTKDFIDILLLSKNEDGSQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLACHPEYQEKCRKEITELLEGKDIKHLEWDELSKLPFTTMCIK
ESLRLHPPVVAVIRRCTEDIKLPKGDILPKGNCCIINIFGIHHNPDVWPNPQVYDPYR
FDPENLQERSSYAFVPFSAGPRNCIGQNFAMAEMKIVLALILYNFQVRLDETKTVRRK
PELILRAENGLWLQVEELKR
CYP4F57v2 Xenopus tropicalis (Western clawed frog)
CX980073.1, CX968437.1, CF589328.1
NM_001015770.1
62% to 4F22
note there are two seqs that differ at only 2 nucleotides
but there are three ESTs that support each sequence so these
are probably alleles.
88% to CYP4F42 X. laevis
scaffold 403 669820-690787 (-) strand
CYP4F57 and CYP4F58 are adjacent and seem to be co-orthologs
of CYP4F42 Xenopus laevis
MLPFLDHFLDSLNMSRTSFRVYIFAAVILMFCLIMCRTIFKMAT
YIYAYIINARRLRCFPEPPRRSWLLGHLGMFMPTEEGLTEISSAICNLRRTLLTWLGP
IPEVSLVHPDTVKPVVAASAAIAPKDELFYGFLRPWLGDGLLLSRGEKWGQHRRLLTP
AFHFDILKNYVKIFNQSTDIMLAKWRRLTAEGPVSLDMFEHVSLMTLDTLLKCTFSYD
SDCQEKPSDYISAIYELSSLVVKREHYLPHHFDFIYNLSSNGRKFRQACKTVHEFTAG
VVQQRKKALQEKGMEEWIKSKQGKTKDFIDILLLSKNEDGSQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLACHPEYQEKCRKEITELLEGKDIKHLEWDELSKLPFTTMCIK
ESLRLHPPVVAVIRRCTEDIKLPKGDILPKGNCCIINIFGIHHNPDVWPNPQVYDPYR
FDPENLQERSSYAFVPFSAGPRNCIGQNFAMAEMKIVLALILYNFQVRLDETKTVRRK
PELILRAENGLWLQVEELKR
CYP4F58 Xenopus tropicalis (Western clawed frog)
NM_001015810.1
64% to 4F22
90% to CYP4F42 X. laevis,
90% to CYP4F57v1 and CYP4F57v2
scaffold 403 641462-661033 (-) strand
CYP4F57 and CYP4F58 are adjacent and seem to be co-orthologs
of CYP4F42 Xenopus laevis
MLPSLDHFLDSLNMSRSSFRVYIFAAVILLFCLIMFRTILKMAI
YIYAYIINARRLRCFPEPPRRSWLLGHLGLFMPTEEGLTEVSNTISNFRKSFLTWMGP
ISLVSMVHPDTIKPMVAASAAIAPKDELFYGFLRPWLGDGLLLSRGEKWGRQRRLLTP
AFHFDILKNYVKIFNQSTDIMLAKWRRLAAVGPVSLDMFEHVSLMTLDTLLKCTFSYD
SDCQEKPSDYIAAIYELSSLVVKREHYLPHHFDFIYNLSSNGRKFHQACKTVHEFTAG
VVQQRKKALQEKGIEEWIKSKQGKTKDFIDILLLSKDEDGNQLSDEDMRAEVDTFMFE
GHDTTASGLSWILYNLACHPEYQEKCRKEITELLEGKDTKHLEWDELSQLPFTTMCIK
ESLRLHPPVTAVSRRCTEDIKLPDGKVIPKGNSCLISIYGTHHNPDVWPNPQVYDPYR
FDPEKLQERSSHAFVPFSAGPRNCIGQNFAMAEMKIVLALTLYNFYMRLDETKTVRRK
PELILRAENGLWLQVEELKQ
CYP4F59P human = CYP4F-se14[6:8]
Chr9:43030439-43031461 (-) strand
CYP4F60P human = CYP4F-se15[6:7:8]
Chr9:44019570-44020591 (-) strand
CYP4F61P human = CYP4F-se16[6:7:8]
Chr9:66367007-66368028 (-) strand
CYP4F62P human CYP4F-se11[6;7:8]
NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
Length = 18291257
chr2q21.1 131461272 131461568 5 DIFFS TO 27P 1 DIFF TO 4F32P
CFLSLASPCRNA
47879 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLT 48058
48059 SQGVDDFLKAKATFKASDFIDALVLSK 48139
48462 QDENGKELSDEDI*MEAGIFMSAG 48533
48727 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 48846
CYP4F63P human = CYP4F2-ie2b
CYP4F64P human = CYP4F3-ie2b
CYP4F65P human
1 kb downstream of CYP4F44P
CYP4F-se1[6:8] human = CYP4F25P
GenEMBL NT_078056.1|Hs9_78125 chromosome 9
Length = 79560
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 65960 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 66106
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 66108 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 66224
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 66811 GYDSTASGLYWILVPLRRHP 66870
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 66878 GVLPPRGARVLRDGNSEDIEW 66940
CYP4F-se2[6] human = CYP4F26P
GenEMBL NT_008413.15|Hs9_8570 Homo sapiens chromosome 9
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
S+Y+AT+ EL ALIV*WHQQICLCMDFLYY PEG CFCRA DLVHNF
Sbjct: 33593291 SDYVATILELHALIV*WHQQICLCMDFLYYLTPEGRCFCRAYDLVHNF 33593434
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQ V D LK +ATFKT DF DALVL K
Sbjct: 33593436 DTIILEQHCTLTSQSV-DILKARATFKTLDFIDALVLSK 33593549
CYP4F-se3[6:7:8] human = CYP4F27P
AC018804.2 Homo sapiens clone RP11-397H17 62% TO CYP4F-se1[6:8]
chr2q21.1 Chr2:130805998-130806965 (-) strand
because the HGNC has strict rules for gene names,
The old names (CYP4F27P, etc.) are being used by the HGNC
These will be synonyms.
21476 LRSCFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTW 21300
21299 CTTSDTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 21171
NT_005079.12|Hs2_5236 Homo sapiens chromosome 2 genomic contig
Length = 4419942
3868414 SEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 3868235
3868234 SQGVDDFLKAKATFKASDFIDALVLSK 3868154
3867831 QDENGKELSDEDI*MEAGIFMSAG 3867760
3867566 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 3867447
chr2q21.1 130711641-130711937
4 DIFFS TO CYP4F-se3[6:7:8]
Query: 1 CFLSLASPCRNASELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTS 180
CFLSLASPCRNASE ADILELSTLIV*RRQ ICLC DFLYYPFLRGDASAGPVTWCTTS
Sbjct: 4 CFLSLASPCRNASEHTADILELSTLIV*RRQ*ICLCLDFLYYPFLRGDASAGPVTWCTTS 63
Query: 181 DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 297
DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK
Sbjct: 64 DTIILQQHRTLTSQGVDDFLKAKATFKASDFIDALVLSK 102
CYP4F-se4[6:7:8] human = CYP4F29P
AL109748 designated CYP4F3LP pseudogene
Nature 405, 311-319 2000 chr21q11.2 14140950-14141905 + strand build 33
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
PEG*CFCRACDLVHNF
DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK
DENGKELSDEDI*MEAGIFMST
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW
CYP4F-se5[6:8] human CYP4F32P
NT_033006.1|Hs2_33182 chromosome 2 4F pseudgene 88% to CYP4F-se1[6:8]
chr2q11.1 94893656-94893866 + strand build 33
22206 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 22114
22112 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 21996
NT_022300.8|Hs2_22456 chromosome 2 88% to CYP4F-se1[6:8]
740635 HQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 740727
740729 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 740845
NT_026970.9|Hs2_27130 Homo sapiens chromosome 2 genomic contig
Length = 2594449
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSAL+V*WHQQICLC DFLYY PEG CFCRA DLVHNF
Sbjct: 99822 PSEYIATILELSALLV*WHQQICLCTDFLYYLTPEGRCFCRAYDLVHNF 99676
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ TLT +GV DFLK KATFK DFSDA +L K
Sbjct: 99674 DTIILEQHLTLTCRGVDDFLKAKATFKILDFSDAFLLSK 99558
Query: 110 TGYDSTATGLY*ILCNLRRH 129
+GYDSTA+GLY IL NLRRH
Sbjct: 98986 SGYDSTASGLYWILYNLRRH 98927
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 98916 GVLPPRGARVLRDRNSEDIEW 98854
CYP4F-se6[6] human = CYP4F33P
NT_030040.6|Hs9_30295 chromosome 9 78% TO 4F26P
chr9p13.1 38532310-38532516 + strand build 33
6944743 HQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLTSQGVDVLKAKATFKTL 6944567
6944566 DFIDALVPSK 6944537
NT_008413.15|Hs9_8570 Homo sapiens chromosome 9 genomic contig
Length = 39435727
Query: 2 SEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTLT 61
S+Y+AT+ EL ALIV*WHQQICLC DFLYY PEG CFC DTIILE+ CTLT
Sbjct: 38532567 SDYVATILELHALIV*WHQQICLCTDFLYYLTPEGRCFCGPATWCSTLDTIILERHCTLT 38532388
Query: 62 SQGVHDFLKTKATFKTWDFSDALVLGK 88
SQGV D LK KATFKT DF DALV K
Sbjct: 38532387 SQGV-DVLKAKATFKTLDFIDALVPSK 38532310
CYP4F-se7[6:7:8] human = CYP4F34P
NT_009799.9|Hs13_9956 chromosome 13 4F pseudogene 78% to 4F27P
343270 HQQICLCMDFLYYXX 343232
343226 PDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 343062
NT_009799.12|Hs13_9956 Homo sapiens chromosome 13 genomic contig
Length = 12392145
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 33
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF
Sbjct: 296823 PSEYIATLFELSALIV*WHQQICLCMDFLYYPF 296725
Query: 32 PFPEG*CFCRACDLVHNFDTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
P P+G DTIILEQ CTLTSQGVHDFLK KATFKT DFSDAL+LGK
Sbjct: 296731 PIPDGDASAGPVTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKT*DFSDALMLGK 296561
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELSDEDI*MEA IFMST
Sbjct: 296237 QDENGKELSDEDI*MEADIFMST 296169
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRD NPEDIEW
Sbjct: 295991 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDRNPEDIEW 295869
CYP4F-se8[6:7:8] human = CYP4F35P
NT_010859.8|Hs18_11016 chromosome 18
84% to 4F12 chr18p11.21 14328070-14328279 + strand build 33
623264 HQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTLTSQGVHDFLKAKATFKTW 623085
623084 DFSDALVLGK 623055
NT_010859.12|Hs18_11016 Homo sapiens chromosome 18 Length = 14719514
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNFDTIILEQPCTL 60
PSEYIATLFELSALIV*WHQQICLCMDFLYYPF G DTIILEQ CTL
Sbjct: 14328016 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFLRGDASAGPMTWCTTLDTIILEQHCTL 14328195
Query: 61 TSQGVHDFLKTKATFKTWDFSDALVLGK 88
TSQGVHDFLK KATFKTWDFSDALVLGK
Sbjct: 14328196 TSQGVHDFLKAKATFKTWDFSDALVLGK 14328279
Query: 88 KDENGKELSDEDI*MEAGIFMST 110
+DENGKELS+EDI*MEAGIFMST
Sbjct: 14328531 QDENGKELSEEDI*MEAGIFMST 14328599
Query: 111 GYDSTATGLY*ILCNLRRHPGVMPSCGARVLRDHNPEDIEW 151
GY+STATGLY*ILCNLRRHPGVMPS GARVLRD NPEDIEW
Sbjct: 14328777 GYESTATGLY*ILCNLRRHPGVMPSRGARVLRDRNPEDIEW 14328899
CYP4F-se9[6:7:8] human = CYP4F30P
NT_005079.12|Hs2_5236 Homo sapiens chromosome 2 genomic contig
Length = 4419942 =
chr2q21.1 131102500-131102796
2 diffs with 4F31P
4259273 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 4259094
4259093 SQGVDDFLKAKATFKASDFIDALVLSK 4259013
4258690 QDENGKELSDEDI*MEAGIFMSAG 4258619
4258425 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 4258306
Query: 1 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 60
SE IADILELSTLIV*RRQ ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT
Sbjct: 1 SEHIADILELSTLIV*RRQ*ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 60
Query: 61 SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL 120
SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL
Sbjct: 61 SQGVDDFLKAKATFKASDFIDALVLSKQDENGKELSDEDI*MEAGIFMSAGGYDSRASGL 120
Query: 121 Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 151
Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW
Sbjct: 121 Y*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 151
CYP4F-se10[6:7:8] human = CYP4F31P
NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
Length = 18291257
chr2q21.1 132067957-132068253
2 diffs with CYP4F30P
654564 SEHIADILELSTLIV*RRQ*ICLCWDFLYYPFLRGDASAGPVTWCTTSDTIILQQHRTLT 654743
654744 SQGVDDFLKAKATFKASDFIDALVLSK 654824
655147 QDENGKELSDEDI*MEAGIFMSAG 655218
655412 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 655531
CYP4F-se11[6:7:8] human = CYP4F62P formerly CYP4F43P but this is a rat seq.
NT_005058.13|Hs2_5215 Homo sapiens chromosome 2 genomic contig
Length = 18291257
chr2q21.1 131461272 131461568 5 DIFFS TO 27P 1 DIFF TO 4F32P
CFLSLASPCRNA
47879 SELIADILELSTLIV*RRQQICLCWDFLYYPFLRGDASAGSVTWCTTSDTIILQQHRTLT 48058
48059 SQGVDDFLKAKATFKASDFIDALVLSK 48139
48462 QDENGKELSDEDI*MEAGIFMSAG 48533
48727 GYDSRASGLY*ILYNLTKHPDIGSAASL*CKSPNPEDIEW 48846
CYP4F-se12[6:8] human = CYP4F44P
NT_008251.13|Hs8_8408 Homo sapiens chromosome 8 genomic contig
Length = 5847381
chr8P11.1 43132635-43132941 + STRAND BUILD 33
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PS+YIAT+ ELSALI+* QQI L DFLYY EG CFCRAC +VHNF
Sbjct: 5439042 PSDYIATILELSALIM*RQQQIFLHRDFLYYVTAEGWCFCRACVVVHNF 5439188
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILEQ CTLTSQGV++FLK ATFKT DF D LVL K
Sbjct: 5439190 DTIILEQHCTLTSQGVNNFLKVTATFKTLDFIDVLVLDK 5439306
Query: 111 GYDSTATGLY*IL 123
GYDSTA+GL+ +L
Sbjct: 5439892 GYDSTASGLFWVL 5439930
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P+ GA VLRDH+PEDIEW
Sbjct: 5439959 GVLPALGAGVLRDHSPEDIEW 5440021
CYP4F-se13[6:8] human = CYP4F45P (name conflict with macaque)
AC018949 62% to 4F3 pseudogene
found in two places 100% match
CYP4F-se1[6:8] chr9p11.2 43742181-43742487 (4F25P) + strand build 33
CYP4F-se13[6:8] chr9q13 63753376-63753682 (4F45P) + strand build 33
NT_078070.1|Hs9_78139 Homo sapiens chromosome 9 genomic contig
Length = 423701
Query: 1 PSEYIATLFELSALIV*WHQQICLCMDFLYYPFPEG*CFCRACDLVHNF 49
PSEYIAT+ ELSALIV* HQQICLC DFLYY PEG CFCRACDLVHNF
Sbjct: 34719 PSEYIATILELSALIV*QHQQICLCTDFLYYLTPEGRCFCRACDLVHNF 34865
Query: 50 DTIILEQPCTLTSQGVHDFLKTKATFKTWDFSDALVLGK 88
DTIILE+ CTLTSQGV DFL KATFK +DFSDA VL K
Sbjct: 34867 DTIILERHCTLTSQGVDDFLNAKATFKIFDFSDAFVLSK 34983
Query: 111 GYDSTATGLY*ILCNLRRHP 130
GYDSTA+GLY IL LRRHP
Sbjct: 35569 GYDSTASGLYWILVPLRRHP 35628
Query: 131 GVMPSCGARVLRDHNPEDIEW 151
GV+P GARVLRD N EDIEW
Sbjct: 35636 GVLPPRGARVLRDGNSEDIEW 35698
CYP4F-se14[6:8] human = CYP4F59P
Chr9:43030439-43031461 (-) strand
CYP4F-se15[6:7:8] human = CYP4F60P
Chr9:44019570-44020591 (-) strand
CYP4F-se16[6:7:8] human = CYP4F61P
Chr9:66367007-66368028 (-) strand
CYP4FA1 see bottom of Cyp4 family entries
4G Subfamily
Cyp4g1 Drosophila melanogaster
no accession number
Waters,L.C. personal communication (1993)
Note: called P450-A1 starts at amino acid 192 and goes to
the end.
Cyp4g1 Drosophila melanogaster
GenEMBL U34328(385bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4g1 Drosophila melanogaster
GenEMBL AL009188 comp (26402-24747) region genomic
Cyp4g1 Drosophila melanogaster
GenEMBL AC020093 comp(33262-34932) no introns
Cyp4g1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4G2v1 Musca domestica (house fly)
Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh,
R. H. ffrench-Constant and R. Feyereisen.
1996. Cytochrome P450 gene clusters in Drosophila
melanogaster. Mol. Gen. Genetics 251: 290-297.
Dta1
corrected from error, previously listed as 4G6
CYP4G2v1 Musca domestica (house fly)
no accession number (559 amino acids)
Claus Tittiger and Gary Blomquist
submitted to nomenclature committee 1/5/98
CYP4G2v1 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #20-3
71% to Cyp4g1 65% to 4g13v2
1 aa diff to 4G2v1 Blomquist and Tittiger 1/5/98
CYP4G2v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #20-1
65% to 4g1 60% to 4g13
99% (4 aa diffs) to 4G2v1 plus 4 frameshifts
CYP4G3 Musca domestica (house fly)
Dunkov, B.C., R. Rodriguez-Arnaiz, B. Pittendrigh,
R. H. ffrench-Constant and R. Feyereisen. 1996.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251: 290-297.
Dt6-139
corrected from error, previously listed as 4G5
CYP4G4 Manduca sexta (tobacco hornworm)
GenEMBL AY635178.1
Snyder,M.J., Guzov,V.M., Stevens,J.L. and Feyereisen,R.
A CYP4G-like transcript expressed in the prothoracic glands of
Manduca sexta
Unpublished
CYP4G4 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4G5 Heliothis virescens(tobacco budworm)
no accession number (382bp)
Richard ffrench-Constant
submitted to nomenclature committee
corrected from error, previously listed as 4G2
Hv-13a
CYP4G6 Heliothis virescens(tobacco budworm)
no accession number (386bp)
Richard ffrench-Constant
submitted to nomenclature committee
corrected from error, previously listed as 4G3
Hv-1
CYP4G7 Tribolium castaneum (red flour beetle)
GenEMBL AF265300
Jeff Stuart
R39
submitted to nomenclature committee
TAAASSFFICILGVYPEIQEKVYQELRDIFQDSDRPITFNDTLQ
MKYLERVLLETLRMYPPVPIITRVINEEVKLASGDYTLPVGTTVGIGQFLVHRNPKYF
PNPDKFDPDNFLPERCQQRHYYSY
CYP4G7 Tribolium castaneum (red flour beetle)
GenEMBL XP_975951
MVVVEESLNHSLNLGNSVLISLGVVAVILAVYHFWLQSLRYTKLGNKIPGYDPLPIIGNAHMVMNKNPTQ
VMELALRVASEKGSVVRFWFGSKLGVALLDPRDIELILGSNVHLEKSSEYRFFEPWLGDGLLISKGDKWR
SHRKMIAPTFHQSILKTFVPVFNKNAMDLVEQLRNEALDQICDVHDYLSGATVDVLLETVMGVKKTKEAR
TSYKYAKAVMDMCTILHFRHVKLWLRSDWIFSFTKLFKEQTSLLRIIHNLTDRVIKQKKKETEEENLKIK
NEQTFNFGSGLRDDLDENDENLGEKKRLAFLDFMVEASQTEGNKLNDEEIREEVNTIMFEGHDTTAAASS
FFICILGVYPEIQEKVYQELRDIFQDSDRPITFNDTLQMKYLERVLLETLRMYPPVPIITRVINEEVKLA
SGDYTLPVGTTVGIGQFLVHRNPKYFPNPDKFDPDNFLPERCQQRHYYSFIPFSAGPRSCVGRKYAMLKL
KILLASIVRNFKIKSVVKEKDFQLQADIILKRADGFRVILTSRT
CYP4G8v1 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86002
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp24
submitted to nomenclature committee
CYP4G8v1 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
86% to 4G15 C-term frag. 98 aa seq #3 HaCypZ006a-v2Pep
note old 4G8, 4G9 and 4G10 were all PCR fragments
the Heme region AGPRNCIGQ is the same in all 3
and it may be a primer used for the PCR that was not
trimmed. only 1 aa diff outside the primer region
CYP4G8v1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_179 has 3 aa diffs to HAH002281
74% to CYP4G36 Aedes
100% to partial CYP4G8 HaCypZ006a-v2Pep
HAH002281 has 3 aa diffs to Contig_179
CYP4G8v2 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp443
submitted to nomenclature committee
CYP4G8v3 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp477g
submitted to nomenclature committee
CYP4G8v4 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp73g
submitted to nomenclature committee
CYP4G9 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86003
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp60
submitted to nomenclature committee
CYP4G9 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
78% to 4G17 C-term frag. 261 aa seq #5 HaCypZ008a-v1Pep
note old 4G8, 4G9 and 4G10 were all PCR fragments
the Heme region AGPRNCIGQ is the same in all 3
and it may be a primer used for the PCR that was not
trimmed. only 1 aa diff outside the primer region.
CYP4G9 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
correct version 60% to CYP4G17, 3 aa diffs to CYP4G9
Contig_165 is missassembled, 1 aa diff to CYP4G9 of Grubor
Contig_166 1 aa diff to Contig_165 1 aa diff to CYP4G9 of Grubor
CYP4G10 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86004
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp5g
submitted to nomenclature committee
CYP4G10X Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
78% to 4G17 C-term frag. 100 aa seq #13
note old 4G8, 4G9 and 4G10 were all PCR fragments
the Heme region AGPRNCIGQ is the same in all 3
and it may be a primer used for the PCR that was not
trimmed. only 3 aa diffs outside the primer region to 4G10
revised longer sequence is diffferent from 4G10 renamed CYP4G26
CYP4G11 Apis cerana cerana (Asian Honeybee)
No accession number
Han Li
Submitted to nomenclature committee July 14, 2013
96% identical to CYP4G11 Apis mellifera (honey bee)
CYP4G11 Apis mellifera (honey bee)
GenEMBL AF207948
S. Tares, J.B. BergŽ and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacÏciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 18Am
CYP4G11v2 Apis mellifera mellifera (honeybee)
No accession number
S. Tares, J.B. BergŽ and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacÏciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 9Am only 2 amino acid differences, one in EXXR motif, possible PCR
errors
CYP4G12 Trichogramma cacÏciae (a parasitoid wasp)
GenEMBL AF207949
S. Tares, J.B. BergŽ and M. Amichot.
Cloning and expression of cytochrome P450 genes belonging to the
CYP4 family and to a novel family, CYP48, in two hymenopteran insects,
Trichogramma cacÏciae and Apis mellifera
BBRC 268, 677-682 (2000)
clone 3Tc 76% identical to CYP4G8
clone 6Tc is identical to 3Tc in the coding region but not in a short
intron this probably represents a recent gene duplication rather than an
allele
CYP4G13 Musca domestica (house fly)
no accession number
Xiaohua Shen, Gary Blomquist
68% identical to 4G1 full length, but different from 4G2 fragment (75%)
and 4G3 fragment (71%)
submitted to nomenclature committee 10/9/98
CYP4G13v2 Musca domestica (house fly)
GenEMBL AF355145.1
Nannan Liu
98% identical to 4G13, may be same gene with some errors between the
two
submitted to nomenclature committee 7/29/99
CYP4G14 Tribolium castaneum (red flour beetle)
GenEMBL AF263514
Jeff Stuart
S19
submitted to nomenclature committee
TAAGSSFFLSMMGVHQDIQDKVVQELYDIFGDSDRPATFADTLE
MKYLERCLMETLRMFPPVPIIARQLNQDLKLASGDYTVPAGCTVVIGTFKVHRLEEYY
PNPDKFDPDNFLPERTANRHYYSFI
CYP4G14 Tribolium castaneum (red flour beetle)
GenEMBL XP_973423, AF263514, AAJJ01000136
82% to 4G29 (shortened N-term in gene model)
MSTTVPTPDISTPSGILSASNVFYFLLIPALLLWYAYWRISKRHMLELAAKIPGPPGLPILGNALDLVGKPH 99617
99569 VFSHVYQKSFEYKKVVKMWAGPKLLVFLTDPSDIELILSSYVHIDKSSEYRFFKPWLGDG 99390
99389 LLISTGQKWKAHRKLIAPTFHLNVLKSFIDLFNANSRDVIRKLQKEIGKEFDCHDYMSEATVEMLL 99192
ETAMGVSKKTQDQSGYDYAMAVMKMCDILHLRHTKFWLRPDIIFNQTKYAEYQKSLINTIHSLTRKV
IKRKRADFDKGIRGSTAEVPPELQTKNYDKTESKTVVEGLSYGQSAGLKDDLDVDDNDIGEKKRMAFLDL
MIEASQNGVVINDEEIKEQVDTIMFEGHDTTAAGSSFFLSMMGVHQDIQDKVVQELYDIFGDSDRPATFA
DTLEMKYLERCLMETLRMFPPVPIIARQLNQDLKLASGDYTVPAGCTVVIGTFKVHRLEEYYPNPDKFDP
DNFLPERTANRHYYSFIPFSAGPRSCVGRKYAMLKLKILLSTILRNYRIYSDLKEKDFQLQGDIILKRAE
GFKVRLEPRKMAKA
Cyp4g15 Drosophila melanogaster
GenEMBL AF159624
M. Ma•bche, D. Bšcking, S. Aragon and C. Dauphin-Villemant.
submitted to nomenclature committee 6/15/99
ESTs AI134510, AI388987, AI403684
Cyp4g15 Drosophila melanogaster
GenEMBL AC013897 comp(8972-10574 and 5306-6643) two pieces
Cyp4g15 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4G16 Anopheles gambiae
GenEMBL AY062189
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450A
79% identical to 4G8
CYP4G16 Anopheles gambiae (malaria mosquito)
GenEMBL AY062189
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x5
CYP4G17 Anopheles gambiae
GenEMBL AY062200
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450L
69% identical to 4G9
CYP4G17 Anopheles gambiae (malaria mosquito)
GenEMBL AY062200
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x3
CYP4G18 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF243507
Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
Insecticide Resistance Associated Cytochrome P450 Gene Fragments
from D. v. virgifera
Unpublished
DvP450-2
CYP4G19 Blattella germanica (German cockroach)
GenEMBL AY176056.1
Nannan Liu
Submitted to nomenclature committee 9/24/02
About 65% identical to Cyp4g15
CYP4G20 Mamestra brassicae (moth)
GenEMBL AY390259
Martine Maibeche
73% to 4G16
submitted to nomenclature committee Sept. 12, 2003
CYP4G21 Anopheles funestus
GenEMBL AY648704
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 4
94% to 4G17 probable ortholog of 4G17
CYP4G22 Bombyx mori (silkworm)
AV404689 prothoracic gland EST spans two contigs
AV405174 prothoracic gland EST
AV404871 prothoracic gland EST
BP183989 P5PG cDNA clone
BP182770 cDNA clone NRPG1026
BP182055 NRPG cDNA clone
BP183011 cDNA clone NRPG1327
BP183771 P5PG cDNA clone
AU004478 EST
BP183321 NRPG cDNA clone
BAAB01118673.1 BAAB01085960.1 84% to 4G20
64% to 4G19
Temp name 4Gxx
MSYTNAENVVPTSTFSAINLFYVLLVPAVILWYAYWRMSRRRLYELADKLNGPPGLPLLGNALEFVGGSA ()
DIFRNIVQKSADYDHESVVKIWIGPRLLVFLYDPRDVEVILSSHVYIDKAEEYRFFKPWLGNGLLIST (1?)
GQKWRSHRKLIAPTFHLNVLKSFIDLFNANSRAVVDKLKKEASNFDCHDYMSECTVEILL (1)
234 ETAMGVSKSTQDQSGFEYAMAVMKMCDILHLRHTKIWLRPDLLFKFTDYAKNQTKLLDIIHGLTKK 431 (0)
988 VIKRKKEEFASGKKPSNLNETATTSEPSTGKLTSVEGLSFGQSSGLKDDLDVDDDVGQK 1164
1165 KRLAFLDLLLESSQSGVAISDEEIKEQVDTIMFE 1266 ()
1340 GHDTTAAGSSFFLSMMGIHQDIQDKVIEELDQIFGDSDRPVTFQDTLEMKYLERCLMET 1516
1517 LRLYPPVPIIARQVNQEITL 1576 ()
1680 SNGKKIPAGTTLVIATYKLHRRPDVYPNPNKFDPDNFLPERSANRHYYAFVPFSAGPRSCV 1862 (1)
1960 GRKYAMLKLKVILSTILRNFRVISDLKESDFKLQADIILKRAEGFQVRLQPRKRMAKA* 2136
CYP4G23 Bombyx mori (silkworm)
CK508129 rswdd0_001928.y1 swd cDNA
CK505752 rswcc0_009305.y1 swc cDNA
AV401408 BP122820 BP123076 BP183420 CK509955 CK505752 CK505553
BAAB01050777.1 BAAB01096227.1 BAAB01156775.1 BAAB01003438.1
BAAB01073763.1 BAAB01110168.1 BAAB01050777.1
58% to 4G19 59% to CYP4G22
Temp name 4Gyy
MTSLVDETEGYHVNSRVIFYPLLGLTTAIWILYRWQQNSHMHKLAELLPGPASIPIFGNALTLMRKNPHE ()
LVNLALGYAQTFGNVIRVWLGSKLIVFLVDADDIEIILNSHVHIDKATEYRFFKPWLGEGLLISS (1?)
GPKWRSHRKMIAPTFHINILKSFVGIFNQNSNNVVEKLKSEVGKTFDVHDYMSGTTVDILL ()
ETAMGISRKTQDESGFDYAMAVMK ()
MCDIIHQRHYKFWMRSEIVFKLTSFFKQQTKLLGIIHGLTNK ()
VIKNKKETYLENKAKGIIPPTLEEFTHHSGEILANNAKTLSDTVFKGYRDDLDFNDENDV ()
GEKKRLAFWDLMIESSQNGTNKISDHEIKEEVDTIMFE ()
GHDTTAAGSSFVLCLLGIHQDVQARVYDELYQIFGDSDRPATFADTLEMKYL
ERVILESLRLYPPVPVIARKLNRDVTI ()
STKNYVIPAGTTVVIGTFMLHRQPKYYKDPEVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1)
GRKYALLKLKILLSTILRNFRTISEIPEKEFKLQGDIILKRAEGFQMKVEPRKRVPTNVAR*
CYP4G24 Bombyx mori (silkworm)
BAAB01149226.1 BAAB01135847.1 BAAB01073803.1 BAAB01199362.1
FIRST TWO EXONS ARE JOINED WITHOUT OVERLAPPING EVIDENCE
BUT THEY ARE THE ONLY OTHER 4G N-TERM SEQUENCES WITHOUT A PARTNER
71% TO CYP4G23
Temp name CYP4Gzz
MSSLLNYNFEFDVPPIFHTLLLAIMIMWM
LHRWQQSSRLFRLGNKLPGPMALPLVGNSLLILGKKAEGW = BAAB01031491.1
VKYALDYSEKYG
TVVRAWAGPKLVVFLTDANDVEVILNSQIHIDKSPEYRFFKPWLGEGLLISSG = BAAB01016193.1
XKWRSHRKMIAPTFHINILKSFMGVFNENSKSVVKKLRSEVGKTFDVHDYMSCVTVDILL
ETAMGITKTTQDAASFDYAMAVMK
MCNIIHQRHYKVWLHFDAIFKLTSLFKKQRELLKTIHGLTNK (0)
VIKKKKFMYLQNKEKGIIPPTIEELTKIKDTNDSIMEDSAKTLSDTVFKGYRDDLDFNDEQDV ()
GEKKRLAFLDLMIESAQNHTCNISDHEIKEEVDTIMFE ()
GHDTTAAGSSFVLCLLGIHQEIQSKV
YDELFEIFGDSDRLVTFADTLQMKYLERVILESLRLYPPVPAIARKLTRDVQI ()
VTNNYIIPAGSTVVIGTFKIHRDPKYHKNPNVFNPDNFLPENTQNRHYYSYIPFSAGPRSCV (1)
GRKYALLKLKVLLSTILRNYKTTSEISEDQFVLQADIILKRYDGFKIRIEPRNKNHSNTV*
CYP4G25 Antheraea yamamai (Japanese oak silkmoth)
GenEMBL AB196795
Yang,P., Onodera,C., Abe,S., Saito,N., Tanaka,H. and Suzuki,K.
Molecular cloning and nucleotide sequence of a cytochrome P450 cDNA
from the wild silkmoth, Antheraea yamamai.
Unpublished
87% to the silkworm seq temporarily named CYP4Gxx (see silkworm seqs)
CYP4G25 Antheraea pernyi (Chinese oak moth, Chinese Tussah moth)
GU205081 not released as of Nov. 24, 2009
Qiuning Liu
submitted to nomenclature committee Nov. 23, 2009
97% to CYP4G25 Antheraea yamamai
CYP4G26 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ013a-v2Pep
Previously assigned to CYP4G10, but the longer sequence is not 4G10
478aa almost complete, 79% to 4Gyy silkworm 80% to 4G10
CYP4G26 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_174 has 1 aa diff to HAH004055 61% to CYP4G17,
6 aa diffs to CYP4G26 HaCypZ013a-v2Pep partial seq
HAH004055 has 1 aa diff to Contig_174
Contig_215 100% to HAH004055 C-term, 2 aa diffs to CYP4G26 of Heckel
CYP4G27 Ips paraconfusus (California fivespined ips, bark beetle)
GenEMBL DQ471883
Dezene Huber
Submitted to nomenclature committee May 19, 2005
65% to 4G22, full length
CYP4G28 Papilio polyxenes (black swallowtail butterfly)
No accession number
Zhimou Wen, Mary Schuler, May Berebaum
Submitted to nomenclature committee June 17, 2005
85% to 4G22 of silkworm
CYP4G29 Leptinotarsa decemlineata (Colorado potato beetle)
GenEMBL DQ117464
Jianhua Zhang
Submitted to nomenclature committee June 29, 2005
65% to 4G15, 74% to 4G28
CYP4G29 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4G294419
65 amino acids from heme to end
CYP4G30 Spodoptera litura (common cutworm)
GenEMBL DQ350811
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RAG3 81% to 4G23
CYP4G31 Spodoptera litura (common cutworm)
GenEMBL DQ350813
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SC2: 80% to 4G23
CYP4G32 Spodoptera litura (common cutworm)
GenEMBL DQ350812
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SD2: 78% to 4G23
CYP4G33 Chironomus tentans (aquatic midge)
GenEMBL AY880065
Londono,D.K., Siegfried,B.D. and Sarath,G.
Induction of cytochrome P450 family 4 by atrazine in Chironomus
tentans
Unpublished
62% to 4G17
CYP4G34 Leptinotarsa decemlineata (Colorado potato beetle)
GenEMBL DQ631644
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4G2535138
61 amino acids from heme to end
67% to 4G17, 62% to 4G7, 60% to 4G29
CYP4G34 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP4 clan
Clone name seq 5
100% to CYP4G34 C-term
CYP4G35 Aedes aegypti (yellow fever mosquito)
CYP4G35 Culex pipiens
CYP4G36 Aedes aegypti (yellow fever mosquito)
CYP4G36 Culex pipiens
CYP4G37 Spodoptera exigua Hubner (beet armyworm)
GenEMBL EF113593
Mo Jianchu
Submitted to nomenclature committee Oct. 30, 2006
98% to 4G31
151 aa fragment
CYP4G38 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-9, 70% to 4G29 Leptinotarsa decemlineata (Colorado potato beetle),
68% to 4G28 Papilio polyxenes
Pediculus genome site
CYP4G39 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-1, 54% to 4g15 Drosophila, 56% to 4G16 Anopheles,
56% to 4G11 Apis, 57% to 4G29 Leptinotarsa decemlineata
Pediculus genome site
CYP4G40 Apocrypta bakeri (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
88% to 4G11 Apis
CYP4G41 Ceratosolen solmsi martchali (Hymenoptera) fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
84% to 4G11 Apis
CYP4G42 Philotrypesis sp (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
85% to 4G11 Apis
CYP4G43 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4G44 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4G45X Bombyx mori (silkworm)
This name does not match any known silkworm sequence
Is is probably an error
CYP4G46 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0090J16 (531 aa, missing N-term)
82% identical to Drosoph. Cyp4g15
CYP4G47 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_c636
86% to 4G28 Papilio polyxenes
CYP4G48 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_2363
74% to 4G23 Bombyx mori
CYP4G49 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4G50 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4G51 Acyrthosiphon pisum (pea aphid)
LOC100164072
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
64% to CYP4G16
CYP4 clan
MVTNVQGVNPLFALSAFNLFFYLLTPAIVLWYIYFRMSRKQLYDLASKIPGSEGLPLLGNALDFMQDPHTIFEKIYERSFEFEKNSPIKMWIGPRLLVFLTDPRDVEVILSSNVYIDKSPEYRLFEPWLGNGLLISTGDKWRAHRKLIAPTFHLNVLKSFVTLFNVNSRDTVSKLRKMGSSTFDIHDFMSECTVEILLETAMGVSKKTQKKSGFEYAAAVMKMCDILHMRHTNLWLKPDFIFNFTKYAKEQVGLLDLIHGLTNNVLAKKKEEFLKKKSLMKEVSDIPAASEEIVETSSTLEVEEVPYGNSFGQSAGLKDDLDVEDDGIGEKKRVAFLDLLIECSENGVVLSDEEVREQVDTIMFEGHDTTAAGSSFFLCLMGAHQDVQQKVVDELYSIFGDSDRPVTFQDTLQMKYMERCIMETLRMYPPVPIISRQIKEKVKLGEDITLPVGATIVIATFKIHRNEDVFPNPEVFNPDNFLPEKSASRHYYAYVPFSAGPRSCVGRKYAMLKLKIILSTILRNFKINSNLTEKDWKLQADIILKRTDGFKLSLEPRKSLAKTAA
CYP4G52 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig04379 540aa
57% TO CYP4G36 Aedes, in the CYP4 clan
CYP4G53 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig8045 523aa
62% TO CYP4G14 Tribiolium, in the CYP4 clan
CYP4G54 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig11924 541aa
55% TO CYP4G14 Tribolium, in the CYP4 clan
CYP4G55 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
82% to CYP4G27 Ips paraconfusus (California fivespined ips, bark beetle)
clone name DPO0818_D23
CYP4G55v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH4-1
95% to CYP4G55 Dendroctonus ponderosae (probable ortholog),
98% to CYP4G55v2
CYP4G55v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH4-2
95% to CYP4G55 Dendroctonus ponderosae (probable ortholog),
98% to CYP4G55v1
CYP4G55v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4E-1
100% to CYP4G55v4
99% to CYP4G55v2
96% to CYP4G55 DPO0818_D23
CYP4G55v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4E-2
100% to CYP4G55v3
99% to CYP4G55v2
96% to CYP4G55 DPO0818_D23
CYP4G56 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
56% to CYP4G44 Nasonia vitripennis (jewel wasp)
clone name DPO1118_C02
CYP4G56v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH5-1
96% to CYP4G56 Dendroctonus ponderosae (probable ortholog),
100% to CYP4G56v2 at thje amino acid sequence level
CYP4G56v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH5-2
96% to CYP4G56 Dendroctonus ponderosae (probable ortholog),
100% to CYP4G56v1 at thje amino acid sequence level
CYP4G56v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4C-1
97% to CYP4G56 DPO1118_C02
97% to CYP4G56v1
small insertion compared to CYP4G56v4
CYP4G56v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4C-2
100% to CYP4G56v1
97% to CYP4G56v3
CYP4G57 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-13
59% to CYP4G7 Tribolium castaneum (aa 64-261)
68% to CYP4G56
CYP4G58 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-4
52% to CYP4G47 Zygaena filipendulae (aa 116-169) C-helix region
52% to CYP4G28 Papilio polyxenes
CYP4G59 Trialeurodes vaporariorum (whitefly)
confidential
CYP4G60 Trialeurodes vaporariorum (whitefly)
confidential
CYP4G61 Trialeurodes vaporariorum (whitefly)
confidential
CYP4G62 Locusta migratoria manilensis
No accession number
Rongrong Yu
Submitted to nomenclature committee Dec. 12, 2010
64% to CYP4G35 Aedes aegypti
CYP4G63 Linepithema humile (argentine ant)
No accession number
CYP4G64 Linepithema humile (argentine ant)
No accession number
CYP4G65 Linepithema humile (argentine ant)
No accession number
CYP4G66 Linepithema humile (argentine ant)
No accession number
CYP4G67 Linepithema humile (ant)
No accession number
CYP4G68 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
Formerly CYP4G63 but changed due to name conflict
77% to CYP4G60 Trialeurodes vaporariorum (whitefly)
CYP4G69 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
Formerly CYP4G64 but changed due to name conflict
66% to CYP4G60 Trialeurodes vaporariorum (whitefly)
CYP4G70 Diaphorina citri Kuwayama (Asian citrus psyllid)
No accession number
Siddharth Tiwari
Submitted to nomenclature committee April 7, 2011
78% to CYP4G43 Nasonia
CYP4G71 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
90% to CYP4G4 Manduca sexta
CYP4G72 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
90% to CYP4G65 Linepithema humile
Formerly CYP4G71, but name conflict
CYP4G73 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
64% to CYP4G71 Heliconius melpomene
CYP4G74 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
88% to CYP4G26 Heliothis virescens
CYP4G75 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
91% to CYP4G8 Helicoverpa armigera
CYP4G75 Spodoptera littoralis
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
98% to CYP4G75 Spodoptera frugiperda (ortholog)
CYP4G76 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
63% to CYP4G29 Leptinotarsa decemlineata,
64% to CYP4G4 Manduca sexta
N-term half
CYP4G77 Plutella xylostella
Gene number CCG008026.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
87% to CYP4G8 Helicoverpa armigera
complete
CYP4G78 Plutella xylostella
Gene number CCG007099.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
79% to CYP4G49 Manduca sexta
complete
CYP4G79 Harmonia axyridis (ladybug)
CYP4G80 Lucilia sericata (sheep blowfly)
CYP4G81 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP4G82 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
4H Subfamily
CYP4H1 Anopheles albimanus (mosquito)
GenEMBL L38682 (382bp) PIR PC2261 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H2 Anopheles albimanus (mosquito)
GenEMBL L38683 (382bp) PIR PC2262 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H3 Anopheles albimanus (mosquito)
GenEMBL L38684 (382bp) PIR PC2263 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H4 Anopheles albimanus (mosquito)
GenEMBL L38685 (382bp) PIR PC2264 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H5 Anopheles albimanus (mosquito)
GenEMBL L38686 (382bp) PIR PC2265 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H6 Anopheles albimanus (mosquito)
GenEMBL L38687 (452bp) PIR PC2266 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H7 Anopheles albimanus (mosquito)
GenEMBL L38688 (382bp) PIR PC2267 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H8 Anopheles albimanus (mosquito)
GenEMBL L38689 (461bp) PIR PC2268 (127 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H9 Anopheles albimanus (mosquito)
GenEMBL L38690 (406bp) PIR PC2269 (135 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4H10X Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R26
submitted to nomenclature committee
note this short sequence has been renamed as CYP4BR1
after the full sequence became known.
CYP4H11X Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R18
submitted to nomenclature committee
note this short sequence has been renamed as CYP4BN6
after the full sequence became known.
CYP4H12v1 Culex pipiens pallens (mosquito)
GenEMBL AF157091
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 125 amino acids
clone name NYDR1 73% identical to 4H7
this sequence has three frameshifts and some poor quality sequence at
the 5 prime end
MFEGHDTTTSGIAFTILQLAKHQHLRQKVYDEIVAILGQGGSKT
TPLTYNNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYF
VHRNPDVYPDPERFDPERFAEGSEQQQRRGPYDYIPFWAGPRNCIGH
CYP4H12v2 Culex pipiens
AF191731
Changliang Zhu
Clone NYDR19 PCR fragment 100% aa identical to NYDR18
98% identical to 4H12v1
1 aa diff to 4H12v4
Submitted to nomenclature committee 9/30/99
This seq was accidentally named CYP4H23v1
TTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKT
TPLTYNNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYI
VHRNPDVYPDPERFDPERFAEGSEQQQRRGPYDYI
CYP4H12v4 Culex pipiens pallens
CB074950.1
NJS1618(7) 497bp, NJ007 in Genbank entry
96% to CYP4H12v5, 6 diffs, 73% to 4H24
99% to 4H12v3 97% to 4H12v1
NSLVIEVDTFMFEGHDTTTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKTTPLTYN
NLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYIVHRNPDVY
PDPERFDPERFAEGSEQQQRREPYDYIPFSAGPRNCIGQNRIPAA
CYP4H12v5 Culex pipiens pallens
CB074949.1
NJS1618(9) 496bp, NJ006 in Genbank entry
96% to NJS1618(7) 6 diffs 71% to 4H24 96% to 4H12v3 95% to 4H12v1
GRGNSIEVDTFMFEGHDTTTSGIALTILQLAKHQDLQQKVYDEIVAILGQEGSKTTPLTY
NNLNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGRDVTVPIYIVHRNPDV
YPDPERFDPERFAEGSEQQQRRGPYDYIPFTAGPRNCIGQNH
CYP4H13 Culex pipiens pallens (mosquito)
GenEMBL AF160259
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 151 amino acids
clone name NYDR3 74% identical to 4H5
This sequence has a retained intron
EVDTFMFEGHDTTTSRISFTIWHLAKYQDVQQRLYEEIDRILGE
DKKHAELTNLKVQESEYLDMVVKESLRLIPPVPIIGRCLLEDMEM
DGVTIPAGTNISIKICNIHTNPKIRPNPEKFDPERFSKTNEDKRGPYDYIPFW
AGPRNCIG
CYP4H14 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450P
94% identical to 4H8
CYP4H14 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r1
CYP4H14 Anopheles funestus
No accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
Submitted to nomenclature committee 1/5/05
92% to 4H14 A. gambiae probable ortholog, 58% to 4H24
also 92% to 4H8 A. albimanus, probable ortholog
CYP4H15 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450B
77% identical to 4H3
CYP4H15 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r2
CYP4H15v2 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450Y
one amino acid difference with 4H15, DNA is 95% identical
CYP4H16 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450C
78% identical to 4H6
CYP4H16 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r1
CYP4H17 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450D
83% identical to 4H16
CYP4H17 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r3
CYP4H18 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450G
77% identical to 4H16
CYP4H18 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPn3r2
CYP4H19 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450K
78% identical to 4H7
CYP4H19 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPa1x1
CYP4H20X Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450O
50% identical to 4H5, 4H7
note the 4H subfamily might really be considered two differernt
subfamilies 4H1,2,3,4,9 in one group and 4H5,6,7,8 in another.
4H20 falls between these.
Renamed CYP4D22
CYP4H21v1 Culex pipiens
AF208660
Changliang Zhu
Clone NYDR15 PCR fragment 79% identical to 4H13
Submitted to nomenclature committee 9/30/99
TTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNVKI
QEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMDGTTIPAGTQINIKIYNIHRNPKIW
PDPERFDPDRFSKTNEDKRGPYDFI
CYP4H21v2 Culex pipiens pallens
CB074948.1
NJS1618(10) 487bp, NJ005 in Genbank entry
98% to CYP4H21v3, 3 diffs, 72% to 4H18, 97% to 4H21
GRGNSIEVDTFMFEGHDTTTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNV
KIQEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMNGTTIPAGTQINIKIYNIHRNPKIW
PDPERFDPDRFSKTNEDRRGPYDYIPFTAGPRNCIGQNH
CYP4H21v3 Culex pipiens pallens
CB270837.1
NJS1618(11) 487bp, NJ009 in Genbank entry
98% to CYP4H21v2, 3 diffs, 71% to 4H18, 96% to 4H21
GRGNSIEVDTFMFEGHDTTTSGISFTIWHLAKHQDVQQKLCDEIDQILGTEKKTAELNNV
KIQEFEYLDMVVKESLRLIPPVPIIGRQLIEDLEMNGTTIPAGTQINTKIYDIHRNPKIW
PDPERFDPDRFSKTNEDKRGPYDYIPFTAGPRNCIGQNH
CYP4H22v1 Culex pipiens
GenEMBL AF190782
Changliang Zhu
Clone NYDR7 PCR fragment 96% identical to 4H22v2, 57% to 4H3
Submitted to nomenclature committee 9/30/99
TTSCISFAAYHIARNTAVQHKLYDEMVQVLGPDFKNAQLTYSNL
QELKYLEMTIKEVLRIHPSVPVIGHKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVF
PEPTRFDPERFNEENSSKRHPYAYV
CYP4H22v2 Culex pipiens
AF190784
Changliang Zhu
Clone NYDR9 PCR fragment 96% identical to 4H22v1
Submitted to nomenclature committee 9/30/99
TTSCISFAAYHIARNPAVQQKLYDEMVQVLGPDFKNAQLTYSNL
QELKYLEMTIKEVLRIHPSVPVIGRKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVF
PEPTRFDPERFNEESSSKRHPYAYV
CYP4H22v3 Culex pipiens pallens
CB074946.1
NJS1618(3) 483bp, NJ003 in Genbank entry
56% to CYP4H12v4, 64% to 4H15, 96% to 4H22v2
NSLVIEVDTFMFEGHDTTTSCISFAAYHIARNPAVQQKLYDKMVQVLGPDFENAQLTYSN
LQELKYLEMTIKEVLRIHPSVPVIGRKSAHDMIIDGSKVPPGIDVAILIYAMHNNPAVFP
EPTRFDPERFNEENSSKRHPYASVPFTAGPRNCIGQNRIPAA
CYP4H23v1X Culex pipiens
AF191731
Changliang Zhu
Clone NYDR18 PCR fragment 100% amino acid identical to 4H23v2
Submitted to nomenclature committee 9/30/99
Note: these sequences are 50% to 4D14 and 47% to 4H7,
But they sort to the 4H cluster on a tree.
1 aa div to 4h12v4, 2 aa diffs to 4H12v1
This seq is 100% identical to CYP4H12v2 not a 4H23 seq
TTSGIAFTILQLAKHQHLQQKVYDEIVAILGQGGSKTTPLTYNN
LNDFKYLDMVIKESLRLLPPVSFIGRRLLEDTEINGVTIPAGLDVTVPIYIVHRNPDV
YPDPERFDPERFAEGSEQQQRRGPYDYI
CYP4H23v2 Culex pipiens
AF190787
Changliang Zhu
Clone NYDR12 PCR fragment 100% amino acid identical to 4H23v1
Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNTSKQVSLAGLTVPPNTNISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV
CYP4H23v3 Culex pipiens
AF191729
Changliang Zhu
Clone NYDR17 PCR fragment 1 diff to 4H23v1
Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNTSKQVTLAGLTVPPNTNISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV
CYP4H23v4 Culex pipiens
GenEMBL AF190783
Changliang Zhu
Clone NYDR8 PCR fragment 2 diffs with 4H23v1
Submitted to nomenclature committee 9/30/99
TASAITFILFSLAKHPDIQQKVYEEVRSVFGDAKDTPTTLSSLN
DLKYLELVIKESLRMFPPVPFISRNISKQVSLAGLTVPPNTSISIGIYNMHHNPDYFP
DPERFVPERFEAERGAEKLNPYAYV
CYP4H24 Anopheles Gambiae (mosquito)
No accession number
Hilary Ranson
Submitted to nomenclature committee 10/15/2001
82% to CYP4H7
clone name Cyp43_3
CYP4H24 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPa1x2
CYP4H25 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r3
CYP4H26 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPc2r4
CYP4H27 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3r1
CYP4H28 Aedes aegypti (yellow fever mosquito)
CYP4H28 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4T2.2
CYP4H29 Aedes aegypti (yellow fever mosquito)
CYP4H29 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 4I1.8
CYP4H30 Aedes aegypti (yellow fever mosquito)
CYP4H30 Culex pipiens
CYP4H31 Aedes aegypti (yellow fever mosquito)
CYP4H31 Culex pipiens
CYP4H32 Aedes aegypti (yellow fever mosquito)
CYP4H33 Aedes aegypti (yellow fever mosquito)
CYP4H34 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 4
58% to CYP4H31 Aedes, 66% to 4H12v5 and 4H12v4
CYP4H34 Culex pipiens
CYP4H35 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 8
74% to 4H29 Aedes, 59% to 4H15 Anoph., 59% to 4H25 Anoph.,
40% to 4D1, 44% to 4H34, 45% to 4D40
The 4H subfamily seems to need to be split
CYP4H35 Culex pipiens
CYP4H36 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 9
72% to 4H29 Aedes, 60% to 4H15 Anoph., 44% to 4H34
CYP4H36 Culex pipiens
CYP4H37 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 10
62% to 4H19 Anoph., 62% to 4H31 Aedes, 59% to 4H34
CYP4H37v1 Culex pipiens
CYP4H37v2 Culex pipiens
CYP4H38 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 16
70% to 4H18 Anoph., 79% to 4H33 Aedes, 53% to 4H34
CYP4H38 Culex pipiens
CYP4H39 Culex pipiens
CYP4H40 Culex pipiens
CYP4H41 Culex pipiens
CYP4H42v1 Aedes albopictus
No accession number
Silas Avicor
submitted to nomenclature committee 3/27/13
73% to CYP4H30 Aedes aegypti
100% to CYP4H42v2 in protein seq
8 nucleotide diffs in coding region
97% to CYP4H43 Aeded albopictus
CYP4H42v2 Aedes albopictus
No accession number
Silas Avicor
submitted to nomenclature committee 3/27/13
73% to CYP4H30 Aedes aegypti
100% to CYP4H42v1 in protein seq
8 nucleotide diffs in coding region
97% to CYP4H43 Aeded albopictus
CYP4H43 Aedes albopictus
No accession number
Silas Avicor
submitted to nomenclature committee 3/27/13
72% to CYP4H30 Aedes aegypti
97% to CYP4H42v1 in protein seq
CYP4I I and O are not used in this nomenclature
4J Subfamily
CYP4J1 Anopheles albimanus (mosquito)
GenEMBL L38691 (433bp) PIR PC2258 (124 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4J2 Anopheles albimanus (mosquito)
GenEMBL L38692 (397bp) PIR PC2259 (132 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4J3 Anopheles albimanus (mosquito)
GenEMBL L38693 (385bp) PIR PC2260 (128 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4J4 Culex pipiens
CPIJ016284
CYP4J4v1 Culex pipiens pallens (mosquito)
AF157092
Zhu Changliang, Dept. of Parasitology, Nanjing University
submitted to nomenclature committee 5/20/99
PCR C-terminal fragment 149 amino acids
clone name NYDR4 63% identical to 4J2
EVDTFMFEGHDTTASALVFIFFQLAREQTVQEHIFNEIHALYDR
KPQADKSFRPQDYAELKFMDRALKECLRLWPPVTFISRAITDDIILADGALLPAGCVG
NVQIFDLHRDPEQFPDPERFDPDRFLPESVDKRNPYAYVPFTAGPRNCIG
CYP4J4v2 Culex pipiens
No accession number
Changliang Zhu
Clone NYDS5 PCR fragment 96% identical to 4J4v1
Submitted to nomenclature committee 9/30/99
TASALVFIFFQLAREQTVQERIFNEIHALYDRKPQADKSFRPQD
YAELKFMDRALKECLRLWPPVTFISRAITDDIVLADGALLPAGCVANVQIFDLHRDPE
QFPDPERFDPDGFLPESVDKRNPYAYV
CYP4J5 Anopheles gambiae
no accession number
Hilary Ranson
Submitted to nomenclature committee 8/9/99
clone name P450J
66% identical to 4J2
CYP4J5 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPk2l2
CYP4J6 Culex pipiens
CPIJ001754
CYP4J6v1 Culex pipiens
GenEMBL AF190776
Changliang Zhu
Clone NYDS3 PCR fragment 95% identical to 4J6v2, 59% to 4J3
Submitted to nomenclature committee 9/30/99
TASAVTFIFFVVAEHPDVQQKLCDEIEASSPHSQYTVKDYNELR
YMDRVIKECLRLYPPVPFIGRTVSEDSWFADHFVPKGSMANVHIWDLYRDPEQFPDPE
RFDPDRFLPENVEKRNPYAYV
CYP4J6v2 Culex pipiens
AF190781
Changliang Zhu
Clone NYDR6 PCR fragment 95% identical to 4J6v1
Submitted to nomenclature committee 9/30/99
TASAVTFIFFVVAEHPDVQQKLYDEIEASRPHSQYTVKDYNELR
YMDRVIKECLRLYPPVPFIGRTVSEDSWFADRFVPKGSMANVHIWDLHRDPDQFPDPE
RFDPDRFLPESVEKRNPYAYV
CYP4J7v1 Culex pipiens
GenEMBL AF190780
Changliang Zhu
Clone NYDR5 PCR fragment 96% identical to 4J7v2, 60% to 4J3
Submitted to nomenclature committee 9/30/99
TASAFTFIFLLVAEHSDVQQALVDEILTVNSSRLDPLAQFTVKD
YNELRYMDRVIKECLRLYPPVPFIGRMINEDSWFGDRFIPKDSMANVLIWDLHRDPKQ
FLDPERFDPDRFLPENVGQRNPYAYV
CYP4J7v2 Culex pipiens
AF190785
Changliang Zhu
Clone NYDR10 PCR fragment 96% identical to 4J7v1
Submitted to nomenclature committee 9/30/99
TASAFTFIFLLVAEHSDVQQALVDEILTVNSSRLDPLAQFTVKD
YNEFRYMDRVIKECLRLYPPVPFIGRMINEDSWFGYRFIPKDSMANVLIWDLHRDPRQ
FLDPERFDPDRFLPENVEQRNPYAYV
CYP4J8v1 Culex pipiens
GenEMBL AF190788
Changliang Zhu
Clone NYDR13 PCR fragment 61% identical to 4J6v2
Submitted to nomenclature committee 9/30/99
TGSAFVFIFLSIANHQDVQERVYQEVHATLHDRSGPAEPLTIQD
YNNLKYMERVLKECMRVYPPVPFISRFVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQ
FPDPERFDPDRFLPEHVEKRNPYAYV
CYP4J8v2 Culex pipiens pallens
CB074944.1
NJS16171(1) 490bp, NJ001 in Genbank entry
98% to 4J8v3, 3 diffs, 61% to 4J10 97% to 4J8v1
NSLVIEVDTFMFEGHDTTGSAFVFIFLSIANHQDVQERVYQEIHATLHDRSDPAEPLTIQ
DYNNLKYMERVLKECMRVYPPVPFISRYVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQF
PDPERFDPDRFLPEHVEKRNPYAYVPFSAGPRNCIGQNRIPAA
CYP4J8v3 Culex pipiens pallens
CB074947.1
NJS1618(8) 490bp, NJ004 in Genbank entry
98% to CYP4J8v2, 3 diffs, 59% to 4J10 97% to 4J8v1
NSLVIEVDTFMFEGHDTTGSAFVFIFLSIANHQDDQERVYQEIHATLHDRSDPAEPLTIQ
DYNNLKYMERVLKECMRVYPPVPFISRFVTEDVRYEDKWIPKGSVISVEIFDLHRDPEQF
PDPERFDPDRFLPEHVEKRNPYAYVPFTAGPRNCIGQNRIPAA
CYP4J9 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPk2l1
CYP4J9 Anopheles funestus
No accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
Submitted to nomenclature committee 1/5/05
88% to 4J9 A. gambiae probable ortholog, 56% to 4J5
CYP4J10 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPk2l3
CYP4J11 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 1
79% TO 4J5 57% TO CONTIG 7 probable ortholog of 4J5
60% to 4J9 and 58% to 4J10
CYP4J12 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 5/13/04
Contig 6 and contig 7 (1 aa diff)
83% TO 4J10 54% to 4J9 and 53% to 4J5
probable ortholog of 4J10
CYP4J13 Aedes aegypti (yellow fever mosquito)
CYP4J13 Culex pipiens
CYP4J14 Aedes aegypti (yellow fever mosquito)
CYP4J15v1 Aedes aegypti (yellow fever mosquito)
CYP4J15v2 Aedes aegypti (yellow fever mosquito)
CYP4J16 Aedes aegypti (yellow fever mosquito)
CYP4J17 Aedes aegypti (yellow fever mosquito)
CYP4J18 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 14
68% to 4J16 Aedes, 54% to 4J9 Anoph.
CYP4J18 Culex pipiens
CYP4J19 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 12
59% to 4J9 Anoph., 71% to 4J19 Aedes
CYP4J19 Culex pipiens
CYP4J20 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 13
54% to 4J5 Anoph., 50% to 4J13 Aedes
CYP4J20 Culex pipiens
4K Subfamily
CYP4K1 Anopheles albimanus (mosquito)
GenEMBL L38694 (379bp) PIR PC2273 (126 amino acids)
Scott, J.A., Collins,F.H. and Feyereisen, R.
Diversity of cytochrome P450 genes in the mosquito, Anopheles
albimanus.
Biochem. Biophys. Res. Commun. 205, 1452-1459 (1994)
CYP4K2 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
73% to 4K1 fragment
SLRAICLH sequence not seen in 4K1 probably bad
joint
CYP4K2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r1
Note very similar to CYP4AR1 (almost in the same subfamily)
CYP4K3 Aedes aegypti (yellow fever mosquito)
CYP4K3 Culex pipiens
4L Subfamily
CYP4L1 Manduca sexta (tobacco hornworm)
GenEMBL L38668 (391bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4L2 Manduca sexta (tobacco hornworm)
GenEMBL L38669 (394bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4L2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4L3 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Kate Aronstein and Richard ffrench-Constant
submitted to nomenclature committee
called evacyp4
CYP4L4 Mamestra brassicae (moth)
GenEMBL AY063501
Martine Maibeche
59% to 4L1 (partial seq)
clone name MbraC5 full length
submitted to nomenclature committee Oct. 5 2001
CYP4L5 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
100% identical to Grubors seq
CYP4L5 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #9 HaCypZ012a-v1Pep
85% to 4L4
CYP4L5 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_173 100% to CYP4L5
HAH001637 100% to Contig_173, 1 aa diff to Contig_172
Contig_172 1 aa diff to Contig_173
HAH001562_2 1 aa diff to Contig_173
Contig_186 1 aa diff to Contig_173
CYP4L5 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
93% to CYP4L5 Helicoverpa armigera
CYP4L6 Bombyx mori (silkworm)
CK535040 BP182824 ESTs
BAAB01121615.1 BAAB01097697.1 BAAB01093085.1 BAAB01107041.1
See silkworm page for sequence
CYP4L7 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee July 26, 2004
75% to 4L4
CYP4L8 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A4
78% to CYP4L4, 91% to CYP4L7
CYP4L9v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SA3 97% to 4L9v2, 3 aa diffs,
87% to 4L4, 91% to 4L7, 88% to 4L8
CYP4L9v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RAG1 97% to 4L9v1, 3 aa diffs,
87% to 4L4 89% to 4L7 86% to 4L8
CYP4L9 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to CYP4L13, 80% to CYP4L12, 77% to 4L5
86% to 4L7, 78% to 4L4, 97% to 4L9v1 (4 aa diffs,
probable ortholog), 95% to 4L9v2 (6 aa diffs)
89% to 4L8, 88% to 4L10
CYP4L10 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RT5 98% to 4L8 2 aa diffs,
78% to 4L4 possible ortholog of 4L8
CYP4L10 Spodoptera litura (common cutworm)
No accession number
Gangfeng Shao
Submitted to nomenclature committee 12/17/2008
Partial sequence I-helix to heme
100% to CYP4L10 of Huang
CYP4L11 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
86% to CYP4L5 Helicoverpa armigera 80% TO 4L3 Helicoverpa armigera
83% to 4L9v1, 80% to 4L10, 80% to 4L8
CYP4L11 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_158 3 aa diffs to CYP4L11 of Rene Feyereisen
HAH001562 100% to Contig_158
CYP4L12 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to 4L5, 80% to CYP4L9, 77% to 4L11, 76% to CYP4L13
89% to 4L4, 87% to 4L9, 78% to 4L8, 77% to 4L10
CYP4L12 Spodoptera littoralis
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
95% to CYP4L12 Spodoptera frugiperda (ortholog)
CYP4L13 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to CYP4L9, 76% to CYP4L12, 72% to 4L5, 69% to 4L11
86% to 4L7, 74% to 4L4, 89% to 4L9v1, 89% to 4L8,
88% to 4L10, 87% to 4L9v2
CYP4L14 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_218 94% to Contig_173 CYP4L5
CYP4L15 Spodoptera exigua (beet armyworm)
No accession number
Gangfeng Shao
Submitted to nomenclature committee 12/17/2008
Partial sequence I-helix to heme
94% to CYP4L4, 97% to CYP4L16
CYP4L16 Spodoptera exigua (beet armyworm)
No accession number
Gangfeng Shao
Submitted to nomenclature committee 12/17/2008
Partial sequence I-helix to heme
93% to CYP4L4, 97% to CYP4L15
CYP4L17 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-12
49% to CYP4L4, 48% to CYP4L7,
probable ortholog of other CYP4Ls in moths
CYP4L18 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: CM4-2
58% to CYP4L4 Mamestra brassicae
55% to CYP4L7 Spodoptera exigua
CYP4L19 Spodoptera litura
No accession number
Gangfeng Shao
Submitted to nomenclature committee May 22, 2009
94% to CYP4L4 Mamestra brassicae, 97% to CYP4L15 Spodoptera litura
97% to CYP4L21, 97% to CYP4L20
CYP4L20 Spodoptera litura
No accession number
Gangfeng Shao
Submitted to nomenclature committee May 22, 2009
92% to CYP4L4, 95% to CYP4L15 Spodoptera litura, 97% TO CYP4L19,
97% to CYP4L21
CYP4L21 Spodoptera litura
No accession number
Gangfeng Shao
Submitted to nomenclature committee May 22, 2009
92% to CYP4L4, 96% to CYP4L15 Spodoptera litura,
97% TO CYP4L19, 97% TO CYP4L20
CYP4L22 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
56% to CYP4L4 Mamestra brassicae
CYP4L23 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP4L24 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP4L25 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
4M Subfamily
CYP4M1 Manduca sexta (tobacco hornworm)
GenEMBL L38670 (397bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4M1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4M2 Manduca sexta (tobacco hornworm)
GenEMBL L38671 (1512bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
CYP4M2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4M3X Manduca sexta (tobacco hornworm)
GenEMBL L38672 (397bp)
Snyder, M.J., Stevens, J.L., Andersen, J.F. and Feyereisen, R.
Expression of cytochrome P450 genes of the CYP4 family in midgut and
fat body of the tobacco hornworm, Manduca sexta.
Arch. Biochem. Biophys. 321, 13-20 (1995)
Name changed to CYP4CG1
CYP4M4v1 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U86005
Pittendrigh,B., Aronstein,K., Zinkovsky,E., Andreev,O.,
Campbell,B., Daly,J., Trowell,S. and ffrench-Constant,R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
pyrethroid-susceptible and -resistant strain
Insect Biochem. Mol. Biol. 27 (6), 507-512 (1997)
hacyp63
CYP4M4v2 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL AF182171
99% to 4M6 in H. zea = ortholog
98% to 4M4v1 (2 aa diffs)
CYP4M4? Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
100% overlap with CYP4M4v2 (14aa) C-term frag. 70 aa
seq #16 HaCypZ019a-v1Pep
this seq may be the C-terminal of CYP4M4
CYP4M5 Bombyx mori (silkworm)
No accession number
Kyoko Kikuchi
54% to 4M2 71% to partial 4M1 sequence 74% to 4M4 partial seq.
submitted to nomenclature committee Jan. 16, 2001
CYP4M6 Helicoverpa zea (corn earworm)
GenEMBL AY113687
Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
submitted to nomenclature committee June 15, 2001
Clone name x32
501 aa 54% to 4M2
CYP4M6v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
98% (9 aa diffs) to CYP4M6 AY113687 Helicoverpa zea
(corn earworm) ortholog
CYP4M6v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH005656 97% to CYP4M6v1
CYP4M7 Helicoverpa zea (corn earworm)
GenEMBL AY113688
Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
submitted to nomenclature committee June 15, 2001
Clone name x39
502 aa 53% to 4M2 77% to 4M4 I-helix to heme
CYP4M7v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
99% 6 aa diffs to CYP4M7 AY113688 Helicoverpa zea
(corn earworm) ortholog
CYP4M7v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_194 97% to CYP4M7
HAH003557 100% to Contig_194
CYP4M8 Trichoplusia ni Family: Noctuidae (caterpillar)
No accession number
Ping Wang
54% to 4M2 70% to 4M1 I-helix to heme (sequence 2)
submitted to nomenclature committee 5/20/02
CYP4M9 Bombyx mori (silkworm)
BAAB01103156.1 BAAB01142776.1 BAAB01178932.1
57% to 4M5
See silkworm page for sequence
CYP4M10v1 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ020a-v1Pep
67% to 4M7
CYP4M10v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
1 aa diff to Heckels seq
CYP4M10v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH001186 has 4 aa diffs to CYP4M10v1
Contig_155 has 1 aa diff to HAH001186
Contig_225 2 aa diffs to Contig_155
CYP4M11 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee June 12, 2005
Clone name sequence 2
70% to CYP4M6 but only I-helix to heme fragment
CYP4M12v1 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A1
76% to CYP4S2
CYP4M12v2 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A11
2 aa diffs to CYP4M12v1
CYP4M13v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RT4 83% to 4M6,
98% or 2 aa diffs to CYP4M12v1 possible ortholog
CYP4M13v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SC4 97% to 4M13v1,
possible allele, 96% to 4M12v1, 81% to 4M6
CYP4M14v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name R35 79% to 4M6
CYP4M14v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SB2 99% (1 aa diff) to CYP4M14v1,
78% to 4M6, 89% to CYP4M15
CYP4M14 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to 4M15, 77% to 4M10, 69% to 4M6, 67% to 4M7,
65% to 4M17, 64% to 4M18, 69% to 4M6, 91% to 4M14v1
and v2, 89% to 4M15, 79% to 4M4v2, 75% to 4M13v1,
75% to 4M12v1, 61% to 4M16, 63% TO 4M11, 65% TO 4M8
possible ortholog of CYP4M14 Spodoptera litura (common cutworm)
CYP4M15 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name R31 89% to 4M14v2, 81% to 4M6
CYP4M15 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
86% to 4M14, 79% to 4M10, 71% to 4M7, 70% to 4M6, 67% to 4M17,
66% to 4M18, 71% TO 4M7, 65% to 4M8, 62% to 4M16,
96% to 4M15 (5 aa diffs),
90% to 4M14v1, 76% to 4M13v1, 77% to 4M12v1, 68% to 4M11
possible ortholog of CYP4M15 Spodoptera litura (common cutworm)
CYP4M16 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SD1 65% to CYP4M14v1, 63% to 4M7
CYP4M17 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
74% to 4M7, 78% to 4M14v1, 73% to 4M13v1, 75% to 4M15,
73% to 4M12v1, 69% to 4M11, 65% to 4M16
CYP4M18 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
95% to 4M13v1 (6 aa diffs in 149aa), 96% to 4M12v1 (5 aa diffs in
149aa), 77% to 4M15, 73% to 4M14v1, 65% to 4M16, possible ortholog of
CYP4M12 or 4M13.
CYP4M19 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189047.1, GenPept ABW34434
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
5 aa diffs to 4M11 this might be a CYP4M11 allele
MFEGHDTTATGLVYLLMSLACDKMIQDKVVEELKEIFGDSTRPA
TMQDLGKMKYLDCCIKESLRLYPPVPFIARILNEEVVLSGYKVPAGTQCNIHIYDLHR
RADLFENPSKFDPDRFLPKNSAGRHPYAYIPFSAGPRNCIGQK
CYP4M20 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189048.1, GenPept ABW34435
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
75% to 4M15 Spodoptera litura
MFEGHDTTASGLVYFLMLLANHRDIQKKVTAELDSIFGSSDRPA
SMADLARMRYLDCCVKESLRLYPPVPFISRELQEPVVLSNYTIPSGMFVHIHIFDLHR
REDLFPDADRFDPDRFLPENSAGRHPYAYIPFSAGPRNCIGQK
CYP4M21 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189049.1, GenPept ABW34436
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
61% to 4M19 Plutella xylostella
MFEGHDTTARALCFLLMSIANEPIVQDTISSELQDIFQGSDRPP
TVEDLHEMKYLECCIREGLRLYPSVPYIARLLKEDTVLSGYVVPAGTIVNIHVFDVHR
RAELFPEPEAFRPERWLAPPPHKYAYVPFSAGPRNCIGQK
CYP4M22 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189050.1, GenPept ABW34437
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
65% to 4M19, 65% to 4M5
MFEGHDTTAMGLTFILMELANNPSVQDKVVQELREIFGQSARPG
SMQDMSQMKYLECCIKETLRLYPPVPFISRYITDTVTLSGHVIPRGKTLCHIHIFDLH
RRADLYPSPLVFNPEQFTAGNCASRHPYAYIPFSGGPRNCIGQK
CYP4M22 Plutella xylostella
Gene number CCG006053.1b
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
95% to CYP4M22 short fragment (I-helix to heme)
with 7 aa diffs (one on the end)
two genes fused
CYP4M23 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189051.1, GenPept ABW34438
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
62% to 4M6 Helicoverpa zea
MFEGHDTTSTALQMIFMLLANNVDSQDKIVEECDRIFGSSDRSA
TMDDLTQMKYLECCIKEGLRLFPPVFFIQRMLTEPMKFREHEVPAGTDCTVFILDLHR
RADQFDEPHSFRPERFLAESPSWHPYSYIPFSAGPRNCIGQKI
CYP4M23 Plutella xylostella
Gene number CCG006053.1a
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
96% to CYP4M23 (I-helix to heme) 3 aa diffs (two on the end)
Two genes fused
CYP4M24 Ostrinia furnacalis (Asian corn borer)
No accession number
Zhang Yuliang
submitted to nomenclature committee Feb. 17, 2009
77% to CYP4M6, partial sequence
CYP4M25 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: CM4-1
59% to CYP4M7 Helicoverpa zea
CYP4M26 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4M27 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
53% to CYP4M10v1 Helicoverpa armigera
CYP4M28 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee May 20, 2011
CYP4M29 Ostrinia nubilalis (European corn borer)
GH996933
CYP4M30 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
90% to CYP4M7 Helicoverpa zea
CYP4M31 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
95% to CYP4M6 Helicoverpa zea
CYP4M31 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
98% to CYP4M31 Heliothis subflexa
CYP4M32 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
83% to CYP4M16 Spodoptera litura
CYP4M33 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP4M34 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
4N Subfamily
CYP4N1 Musca domestica
Rene Feyereisen
submitted to nomenclature committee
CYP4N2 Musca domestica (house fly)
Rene Feyereisen
submitted to nomenclature committee
CYP4N3X see CYP4D8
CYP4N4X see CYP4E4
CYP4O1 I and O not used in this nomenclature
4P Subfamily
Cyp4p1 Drosophila melanogaster
GenEMBL U34327(379bp)
Dunkov,B.C., Rodriguez-Arniaz,R., Pittendrigh,B.,
ffrench-Constant,R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genet. 251, 290-297 (1996)
Cyp4p1 Drosophila melanogaster
GenEMBL AC018129 comp(67703-69662)
ESTs AI405947 AI109737 AI293255
GSS AL063060 722-913
Cyp4p1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4p2 Drosophila melanogaster
GenEMBL AC018129 comp(70087-72192)
EST AI389883
GSS AL055774 comp(4-805) AL063060 28-294
Cyp4p2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4p3 Drosophila melanogaster
GenEMBL AC018129 comp(65426-67385)
No ESTs no GSSs
Cyp4p3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4P4 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4P
63% to 4P1 (140 aa)
CYP4P5 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
56% to CYP4p1 Drosophila melanogaster
CYP4P6 Bactrocera orientalis (oriental fruit fly)
No accession number
Yong Huang
Submitted to nomenclature committee March 16, 2012
66% to CYP4P5 Bactrocera dorsalis
4Q Subfamily
CYP4Q1 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S2
submitted to nomenclature committee
CYP4Q1 Tribolium castaneum (red flour beetle)
GenEMBL XP_971238
69% to CYP4Q2, 63% to 4Q7
MLLSTTLVCAIGLLGVFHLLAWIKFHASNYMKMCVIPGPPQKGILIGNMTYLQTTPEKIFLRLREATKNF
YPIYKLNALHKCAANILNPEDCELIMSNSAHNQKGQIYDLLRNWLKDGLLTSFGAKWQTRRKILTPAFHF
SILQQFVQIFNEEAEILVEDLKKDCSKSYISISSHITKFTLKTIAETAMGSKLKFETQKEIDYYQAVYDV
GKILLYRLTHPWFIFHYVNFFSPWYLQEVKVTKTLHNFTREVIKHREENFKDIELPTEEHEVYKGKKRLA
MLDLLLSAKHKEGIVENDGIQEEVDTFMFKGHDTTSAALCFALMLIASHSEVQESIVAEMREVLGDLSKK
PSYNDLQNLKYLERCIKETLRLYPSVHFISRTLGQDLITTGGYTLPKESNAIIHIYDVHHNADIYPDPEK
FDPDRFLPENVQKRHPYAYLPFSAGPRNCIGQRFAMLELKTAICAILANFTLQPIDTPETIILVVDIILR
TKEPIKIKFVPRS
CYP4Q2 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S35
submitted to nomenclature committee
CYP4Q2 Tribolium castaneum (red flour beetle)
GenEMBL XP_971175
69% to CYP4Q1
MFASTLILTTIFAIVSVLAFKRIKYHVKNYILLNKLPGPPPDGLFVGNMPYLQTTPEDIFNRLREANKKF
YPIYKLFAVHRMGANILSPEDSEIVLSNPIHNEKGYIYKLLHHWLKEGLLTSKGEKWQLRRKILTPAFHF
NILQQFIMILNEEAEKLVEGLRKECHKPYINITPHISQFTLKSITETAMGTKLDFTTKKEIRYKEAVYKI
GKILTYRITHPWFIEPLLNIFSPCFIQERRVTSTLHKFTKEVIEDREKNFKDFELPTEEHDVYKGKKRLA
MLDLLLSAKKKDGIIDNKGIQEEVDTFMFEGHDTTAVALNFALMLIACHKDVQETILQEMRDVLGDIHAK
PTYSDLQNLKYLERCIKESLRLYPSVHLISRALGEDVRTQKGYLIPKDTITIIHIYDLHHNPDIYPDPEK
FDPDRFLPENCQNRHPFAYLPFSAGPRNCIGQRFAMLELKAAICAILANFVLEPIDTPETIVVVVDIVLR
TKEGIKIRFVPREQ
CYP4Q3 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R15
submitted to nomenclature committee
CYP4Q3 Tribolium castaneum (red flour beetle)
GenEMBL XP_971112
66% to 4Q7
MLLSSSVLFVISFFLVLYFFKKLKCVSAKLYNLGKLDGPSNHNIIIGNVLRLH
AAPEVIFKKLRQWARDYYPVYQLRAIHIPAACILAPEDFEAILSNPRHIEKSMVYLLLHDWLGTGLLTSG
GQKWATRRKILTPAFHFSILQQFITIFNEETDKLVDTFKQQCDQPIEITSHITQFTLKTIGETAMGTKFE
FTTRKQIEYKQAILEIGEILLYRLLNSWLISDYLNFFSPHRLREKRLVKTLHTFTRDVITEREKTFEKFQ
LPTEEHDVYIGKKRLAMLDLLLTAKNEERTIDEDGIREEVDTFMFEGHDTTSAALSFALMLLANHKNVQD
QIVDEMVTVLGDLHQKPTYNNLQEMKYLERAIKESLRLYPSVHFISRKLGEDFVTCNGLKLPKSTITHLH
IYDLHHNPDIYPDPEKFDPERFRPENSQKRHPFAYLPFSAGPRNCIGQKFAMLELKAAICGILANFILEP
VDTPESIVLVVDLVLRTKNGIKIGFIPRVK
CYP4Q4 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S1
submitted to nomenclature committee
CYP4Q4 Tribolium castaneum (red flour beetle)
GenEMBL AAP94193, 98% to AF251548_1 (7 aa diffs)
57% to 4Q5
MFLAPIILCLVLLALLVSSLRKKGRFWECLAPIPQPPAYPIIGNLFDIMRTPEQMFLADRERGLKYYPIY
KLDVCGTGGVNLLNPEDVELVLTDTKQNTKSFIYHFLHSWLGTGLLTSRGPKWQNRRKILTPAFHFNILQ
EFIQIFNEETKRLVEDLEAESHKPYIDVVVPITQFTLLSIGETAMGIKLNASDNDKDGYKRAVYKIGQLL
TYRAPRPWIHNETIYSLTPQGRKEQKVLKSLHSFSNNVIAERKKHFSSSSYSSRKRLAMLDLLLKYKSEG
ANIDDEGIREEVDTFMFEGHDTTSVSICYTLMLLANHREVQEEILKEMEAVLDEEPPTYAKLQELKFMDR
VIKESLRLYPSVPFISRVSGSEIQTKTGYTIPKDCMVNLQIYDMHHNPNVFPDPEKFDPDRFLPENIQKR
HPFAYIPFSAGSRNCIGQKFAMLEIKTVLCGILKKFILEAVDTRKDMAFVSDLVLRPKGSIKVKFVPRRAN
CYP4Q5 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S58
submitted to nomenclature committee
CYP4Q5 Tribolium castaneum (red flour beetle)
GenEMBL XP_971423
57% to 4Q4
MIQSTLLLIFIVILSVIIYIWWYQNFSRFFSLLNKVPGPPGYPIIGNIIQFLATPEELFKIDRELGRRFY
PIYKEWTLTYGAVNLLHPDDIELVLSNSKYNDKSAIYDFLHCWLGTGLLTSSGTKWQTRRKVLTPAFHFN
ILQQFLPIFNEETVKLIKNIKNDQPIDVIPPVTQFTLLSIAETSMGVKLDASPKSCDDYKNAIHVFGYAL
TYRLGRPWLHNPFVFFNLTRLGHLTKKSIKILHDFSRNVIEQKKRTFEGEKRGKRLAMLDLLLLAKHQGA
DIDDEGIAEEVDTFMFEGHDTTSIAICYTLLLLANHPDIQDELYSELKSVLSDPTQTPSYSDLKQLNLME
RCIKESLRIFPSVPFISRLLTEDLTTASGYVIPRGSMAHIHIYDLHNNPEIYPDPKKFDPDRFLPENCQK
RHPFAYLPFSAGPRNCIGQKFAMLELKVVLSGILGNFVLEAVDKPKDVTMITDLVLRCKGPIRVKFVPRYKIN
CYP4Q6 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R4
submitted to nomenclature committee
CYP4Q6 Tribolium castaneum (red flour beetle)
GenEMBL XP_970404, AAJJ01002630.1
54% to 4Q4
MLSFYLLLTGVGLILLLQTWRFFRKYFKNKTILKKIRGPPETPIFGHMYIFTQDP (1)
DLLFSRIRKYSREYYPIFRFSALYVDIVNFLEPNDIELILSTTKHLSKSKIYTFLNNWLGTG
LLTSTGAKWHQRRKILTPAFHFNILQQFLNIFNDETEKLVLRLGEDCGRTIDVVPPVTNFTLQSIAETAM
GLSNINELTQKEYKKAIYKIGHIFLKRLSKPWYRLDAIYNYSKLAEEENATVKILHDFSNGIISEREKER
TTNLSQNLASYSKKKRMAMLDLLLAAKNEGADIDYEGIREEVDTFMFEGHDTTSMAISFILLTLANLQDV
QTKVREEILSVVGKEKIPTYNDLQELKYTERCIKETLRLFPSVPFISRYASEDFVTKTGYTIPEGTVLHI
HIFDLHRNAEIYPDPLKFDPDRFLPEKVNERHPFAYIPFSAGPRNCIGQKFAFLELKTVLCGILRKFKLE
KVDDMYEIEFRPDLVLRPKNDVKVRIEKL
CYP4Q7 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
formerly CYP4R1 (sequence revised 1/29/99)
submitted to nomenclature committee
CYP4Q7 Tribolium castaneum (red flour beetle)
GenEMBL AF254755_1
66% to 4Q3
MLVLTTVLTAAAVFLLFYLFYCYKTIKQHIYSLISLSYLPGPPVNDIISGNILPLYTSAENIFKQLREWG
RLYYPIYKLNAAHLAAANILSPEDCELVLSNPTHMEKSAIYNLLHDWLGTGLLTSTGLKWQTRRKILTPA
FHFSILQQFVAIFNEETDKLVEVLKEECYKPFINVNAHVAQFTLKTIAETAMGTKLRFTTRKETIYKQSI
VDMGEFLLYRLLRCWLISKCIYVFNPRYYLEKKVTRRLHRFTKSVIAERQENFKEIVVPETDEVYTGKRR
LAMLDLLLTAKNKEGLIDDEGIREEVDTFMFEGHDTTAAALGFALMVLAGHKEVQDKIVEEMNEVLGDIK
KKPTYQDLQEMKYLERCVKEVLRLYPSVHFISRKLGEDLVTHSGHKLAKGSIVNLHIYDLHHNPAIYPDP
EKFDPDRFLPENCQKRHPFAYLPFSAGPRNCIGKKFAMLELKAAICGILANFTLEPIDIPETIVLVVDIV
LRTKEGIKVRFIPRV
CYP4Q8 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
R22
submitted to nomenclature committee 1/29/99
CYP4Q8 Tribolium castaneum (red flour beetle)
GenEMBL XP_970987
68% to 4Q7
this seq is short
AAJJ01001877.1 N-term only runs off this contig
AAJJ01002307.1 C-term part, missing ETAM exon
MVLENIIIGLAAATAICYLFKQLIEMALVIFFVQKMPGPRKFNLFYGNMRPLHSSPAEIFNVLRKWGLEY
YPIYKLWLFFVSVANIMSPEDLALILPDMKHSKKSIAYDLIHRWLGSGLLTSYGTHWQVRRKILTPAFHF
SILQDFILTFNESTEELVELLKKEVEKPFVEITPLITXXXXXXXX
xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx
PKFYEERKLIKLLHNFTNDIIAKRRKDFHQGIVASQ
KKKRLAMLDLLLTVQKEEGIIDDEGIREEVDTFMFEGHDTVSSAINFALMVLANHPTVQEEIVQEMKDVL
GDTKKKPVYNDLQELKYMERVIKEVLRLYPSVHYISRELGEDMVTTTGYKLRKGTILQLHIYDLHYNPVI
YPEPEKFDPDRFLPENCDKRHPYAYIPFSAGPRNCIGQRFAMLELKAVLCGILSNFTLQPVDTPESIVMV
EDIVLRTKENIKVKFVPREM
CYP4Q9 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S25
submitted to nomenclature committee 1/29/99
CYP4Q9P Tribolium castaneum (red flour beetle)
GenEMBL AF265297_2, AAJJ01002307.1, 6 P450s on this contig
66% to 4Q7
Some frameshifts and a bad boundary, probable pseudogene
MIILLIIVALVLALFLKPLGHYISIIKYVQQLPGPPCENFLHGNITHLYGPP (1)
EKMFKTVRKWGLEYYPIYQNWIAHVAVANVMNPYDFEV (1?)
ILSNMKH TSKSMIYDMLHCWLGTGLLTSDGIKWQTRRKILTPAFHFNILQEFIKIFNEETETLVQQL
KKHSNSSVDVTEYISAFTLNTIG (1)
ETAMGTSFGTETSTGREYKKSIQEIGEILKYKLLRPWLLSKFVYVCDPNYWKEIKLVKIL
HNFTNNVIANRQSNFKPVEQKSDEFSYSRRKRMAMLDLLLTAKNEDNLIDDEGIREEVD
TFMFEGHDT
2269 TAVAICFALMCIACHPDIQ (0)
ERIFEEIEETFSDDTKPDYKSLQELKYMERCIKEVLRLYPSVPFIARSLGE
DIVTYSGHKLKAGSMVHLHIYDMHHNPQVYPDPEKFDPDRFLPENCLKRHNFAYVFP 2694
SAGPRNCIGQKFAILEMKAVLVGILKEFTLEPVD
VDTPETLVMKTDLVLRAMNGVRVKFVPRICAK*
CYP4Q10 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4Q53c63
64 amino acids from heme to end
49% to 4C3, 51% to 4C25, 66% to CYP4Q3 = XP_971112,
67% to 4Q11
CYP4Q11 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4G758106
64 amino acids from heme to end
53% to 4J9, 52% to 4C3, 68% to CYP4Q8 = XP_970987
CYP4Q11? Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-6
67% to CYP4Q5 Tribolium castaneum
62% to CYP4CV1, 63% to CYP4BG2v2
identical to CYP4Q11 in 18 aa overlap at heme region
identical to CYP4BN14v1 in 18 aa overlap at heme region
CYP4Q12 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
51% to CYP4Q7v1 Tribolium, best hits are all CYP4Qs
nearly complete seq.
CYP4Q13 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
49% to CYP4Q12 N-term
half complete seq.
4R Subfamily
CYP4R1X Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
S11
submitted to nomenclature committee
sequence revised now it is CYP4Q7
4S Subfamily
CYP4S1 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp59a
submitted to nomenclature committee
CYP4S1v2 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ021a-v2Pep
73% to 4S4 95% to 4S1 only 4 aa diffs not on the extreme ends
of the original 4S1 PCR fragment. Probably the same gene.
CYP4S2 Helicoverpa armigera (Australian cotton bollworm)
no accesssion number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp58
submitted to nomenclature committee
Cyp4s3 Drosophila melanogaster
GenEMBL AC018488 comp(98620-101060) also AC015418 AC018487
Cyp4s3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4S4 Mamestra brassicae (moth)
GenEMBL AY063500
Martine Maibeche
86% to 4S1 (partial seq)
clone name MbraB1 full length
submitted to nomenclature committee Oct. 5 2001
CYP4S5 Bombyx mori (silkworm)
BAAB01177041.1 BAAB01181662.1 BAAB01048279.1 BAAB01025317.1
64% to CYP4S4
See silkworm page for sequence
CYP4S6 Bombyx mori (silkworm)
BAAB01121123.1 BAAB01054179.1 BAAB01073078.1 BAAB01008096.1
BAAB01081659.1
94% to 4S5
See silkworm page for sequence
CYP4S7 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4S
71% to 4S3 (266 aa)
CYP4S8v1 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A2
76% to 4S2
CYP4S8v1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
98% to CYP4S8v4 Spodoptera frugiperda partial seq. (ortholog)
CYP4S8 fragment 1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
79% to CYP4S12 Helicoverpa armigera
(may be the N-term of CYP4S8v1 or an allele
2 aa diffs in 24 aa overlap)
CYP4S8v2 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A6
1 aa diff to CYP4S8v1
CYP4S8v3 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee July 7, 2005
Clone A9
1 aa diff to CYP4S8v1
CYP4S8v4 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SB1 84% to 4S2, identical to 4S8v1
except for a short frameshifted region.
The CYP4S8v1 sequence is probably wrong in this region.
CYP4S9v1 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name RTH17 78% to 4S4, 97% to 4S9v2
CYP4S9v2 Spodoptera litura (common cutworm)
No accession number
Shuijin Huang
Submitted to nomenclature committee 10/28/2005
PCR fragment from I-helix to heme
Clone name SA4 78% to 4S4, 97% to 4S9v1
CYP4S10v1 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee Dec. 10, 2005
Clone name Sequence 4 NB5 fragment (C-terminal)
76% to 4S9v2 73% to 4S4
CYP4S10v2 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189052.1, GenPept ABW34439
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
1 aa diff to 4S10v1, 75% to 4S9v1
CYP4S10 Plutella xylostella
Gene number CCG002092.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
98% to CYP4S10v1, nearly complete
CYP4S11 Spodoptera exigua Hubner (beet armyworm)
No accession number
Mo Jianchu
Submitted to nomenclature committee Oct. 30, 2006
95% to 4S8v4
146 aa fragment
CYP4S12 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_149 59% to CYP4S5, 44% to CYP4M7
HAH002398 has 1 aa diff to Contig_149
CYP4S13 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH006401 67% TO CYP4S5, 45% to CYP4M15, 45% to CYP4J9
CYP4S14 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_232 64% to CYP4S13
HAH001808 100% to Contig_232 95% TO CYP4S12 N-term,
56% TO CYP4S5, 54% TO CYP4AX1, 42% to CYP4M10
CYP4S15 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4S16 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
59% to CYP4S13 Helicoverpa armigera
CYP4S17 Heliothis subflexa
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
95% to CYP4S17 Heliothis virescens
CYP4S17 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
90% to CYP4S1v2 Helicoverpa armigera
CYP4S18 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
66% to Cyp4s3 D. pseudoobscura
clone name 1141
CYP4S19 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP4S20 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
4T Subfamily
CYP4T1 Oncorhynchus mykiss (rainbow trout)
GenEMBL U82983
Patrick Falckh
closest resemblance to CYP4B
CYP4T2 Dicentrarchus labrax (European sea bass)
GenBank AF045468
Sabourault,C., Berge,J., Lafaurie,M., Girard,J.P. and Amichot,M.
Molecular cloning of a phthalate-inducible CYP4 gene (CYP4T2) in
kidney from the sea bass, Dicentrarchus labrax.
Biochem. Biophys. Res. Commun. 251, 213-219 (1998)
69% identical to 4T1 fragment
authors name CYP4DL1
CYP4T3v1 Xenopus laevis (African clawed frog)
GenEMBL AB022671, SwissProt Q9PVV8
Satoru Yamamoto
Clone XL-304
58% identical to CYP4T2 62% to 4T1
submitted to nomenclature committee Oct 19, 1999
MWNALVWQQVAALLCLLAVLLKATQIYLSKKRQERILEQFPGPP
RHWLLGNVDQIRRDGKDLDLLVNWTQSHGGAYPVWFGNFSSFLFLTHPDYAKVIFGRE
EPKRQLSYNFLVPWIGNGLLVLTGPKWFQHRRLLTPGFHYDVLKPYVKLISKCTTDML
DNWEKLITKQKTVELFQHVSLMTLDSIMKCAFSYESNCQKDSDNAYIKAVFDLSYLAN
LRLRCFPYHNDTIFYLSPpwvsispslqnnsEHTDKVIQQRKESMKHEKELEKIQQKR
HLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQTMEWKDLGKIPYTNMCIKESLRIYPPVPGVARMLRNPVTFFDGR
SIPAGTLVGLSIYAIHKNPAVWEDPEVFNPLRFTPENSANRHSHAFVPFAAGPRNCIG
QNFAMNEMKIAVALTLNRFHLAADLENPPILIPQLVLKSKNGIHVHLNKVQ
CYP4T3v2 Xenopus laevis (African clawed frog)
SwissProt Q766Z0 100% to Q5XG47
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
99% to 4T3 1 aa diff (PCR from I-helix to heme)
TASGISWILYCMAKYPEHQQKCREEIKEVLGDRQTMEWEDLGKIPYTNMCIKESLRIYPP
VPGVARMLRNPVTFFDGRSIPAGTLVGLSIYAIHKNPAVWEDPEVFNPLRFTPENSANRH
SHAFVPFA
CYP4T3v2 Xenopus laevis (African clawed frog)
SwissProt Q5XG47
lower case possibly frameshifted in 4T3v1, 4 other aa diffs
MANEAVLGSMWNALVWQQVAALLCLLAVLLKATQIYLSKKRQERILEQFPGPPRHWLLG
NVDQIRRDGKDLDLLVNWTQSHGGAYPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSLS
YNFLVPWIGNGLLVLTGPKWFQHRRLLTPGFHYDVLKPYVKLISKCTTDMLDNWEKRIT
KQKTVELFQHVSLMTLDSIMKCAFSYESNCQKDSDNAYIKAVFDLSYLANLRLRCFPYH
NDTIFYLSPhgyrfrqackithEHTDKVIQQRKESMKHEKELEKIQQKRHLDFLDILLF
ARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIKEVLG
DRQTMEWEDLGKIPYTNMCIKESLRIYPPVPGVARMLRNPVTFFDGRSIPAGTLVGLSI
YAIHKNPAVWEDPEVFNPLRFTPENSANRHSHAFVPFAAGPRNCIGQNFAMNEMKIAVA
LTLNRFHLAADLENPPILIPQLVLKSKNGIHVHLNKVQ
CYP4T3 Xenopus tropicalis (Western clawed frog)
DR860523.1 CX967683.1 DT412234.1 DR834559.1
93% to CYP4T3v2 of Xenopus laevis (ortholog)
best match in human = CYP4B1 55%
note: macrosynteny between Danio and human shows CYP4T
is related to the CYP4ABXZ locus. CYP4B may be the parent
gene in this cluster since it is most similar to CYP4T.
MWNTLVWQQVA
ALLCLLAVLLKATQLYLSQKRQENIFKQFPGPPRHWLLGNVDQIRRDGKDLDLLVNWTHK
NGGAFPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSISYDFLVPWIGKGLLVLTGPKWFQ
HRRLLTPGFHYDVLKPYVNLISKCTTDMLDNWEKLITKQKTVELFQHLSLMTLDSIMKCA
FSYDSNCQKDSNNAYIKAVFDLS
YVANLRLRCFPYHNDTVFYLSPhgyrfrkacrithEHTDKVIQQRKESMKLEKELEKIQQ
KRHLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQIMEWEDLGKIPYTNMCIKESLRMYPPVPGVARQLRNPVTFFDGRSV
PAGTVIGLSIYAIHKNPAVWEDPEVFNPLRFSPENSANRHSHAFLPFAAGPRNCIGQNFA
MNEMKVAVALTLNRFHLAPDLENPPIRIPQLVLKSKNGIHVHLTKVQ*
CYP4T4v1 Xenopus laevis (African clawed frog)
SwissProt A2VD77
79% to CYP4T6 X. tropicalis
78% to CYP4T6 Q6AZQ1 X. laevis
MASNLWEVLSSPGLFGNIYQFGQFAAQLCLVLLLLKAWGLFIRWKSLKDALQNFPGPPK
HWLYGHANQFRGDGTDMDRVLAWADKYPKAFPMWVGQFFANLIITNPEYAKAVFARSDP
KTPTGYNFLIPWIGKGLLVLSGDKWFQHRKLLTPGFHYDVLKPYVRLISDSTNVMLDKW
VSFSNKGETVELFHHVSLMTLDSIMKCAFSYHSNCQTDKDNSYTKAVYDLSFLAHHRAR
TFPYHNNLIYYLSPHGFLFRKACRIAHQHTGKVIKQRKTLLQNKGEFEKVKQKRHPDFL
DILLCARDENGKGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEI
REVLGEKDSFEWEHLSKIPYTTMCIKESLRLYPPVPGVSRELNKPITFYDGRSLPAGSV
IFINIFCIHRNPSVWKDPEVFDPLRFSSENSSKRHSHAFVPFAAGPRNCIGQNFAMNEL
KVAVALTLNRYELSPHLSKPPLKSPQLVLRSKNGIHVYLKKAS
CYP4T4v2 Xenopus laevis (African clawed frog)
GenEMBL AB022672
Satoru Yamamoto
Clone XL-301
98% to CYP4T4v1 (4 aa diffs)
93% to CYP4T4 X. tropicalis, 70% identical to CYP4T3
submitted to nomenclature committee Oct 19, 1999
KQCAGLFCVFASHSNLCIAYEMQKPLIVTQILAGKGLLVLSGDK
WFQHRKLLTPGFHYDVLKPYVRLISDSTNVMLDKWVSFSNKGETVELFHHVSLMTLDS
IMKCAFSFHSNCQTDKDNSYTKAVYDLSFLAHHRARTFPYHNNLIYYLSPHGFLFRKA
CRIAHQHTGKVIKQRKTLLQNKGEFEKVKQKRHPDFLDILLCARDENGKGLSDEDLRA
EVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIREVLGEKDSYEWEHLSKIPY
TTMCIKESLRLYPPVPGVSRELNKPITFYDGRSLPAGSVIFINIFCIHRNPSVWKVPE
VFDPLRFSSENSSKRHSHAFVPFAAGPRNCIGQNFAMNELKVAVALTLNRYELSPDLS
KPPLKSPQLVLRSKNGIHVYLKKAS
CYP4T4 Xenopus tropicalis (Western clawed frog)
scaffold_1:2677138-2694187
93% to CYP4T4 X. laevis (ortholog)
MASNLWEVLSSPGLPGNIYQFGQFAALLCLILLLLKACGLFIRWKSLKDALQNFPGPPKHWLYGNANQ (0)
FRNDGTDMDRILLWANKYPKAFPLWVGQFFASLVITNPEYAKAAFARS (1)
DPKTPTGYDFLIPWI (1)
GKGLLVLSGDTWFQHRRLLTPGFHYDVLKPYAKLISDSTKVML (0)
DKWVPFSNKGEPVELFHHVSLMTLDSIMKCAFSYHSNCQTDN (2)
DNSYTKAVYDLSYLTHHRARTFPYHNNLIYYLSPHGFLFRKACRIAHQHT (1)
DKVIKQRKTLLQNKEEFEKVKQKRHPDFLDILLCAR (0)
DENGKGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQKCREEIRDVLGEKESFEW (2)
EDLNKIPYTTMCIKESLRLYPPVPAVSRELNKPITFSDGRSLPA (1)
GSVIFINIFCIHRNPTVWKDPE (0)
VFDPLRFSSENSSKRHSHAFVPFAAGPR (2)
NCIGQNFAMNELKVAVALTLNRYELSPDLSKAPLKSPQLVLRSKNGIHVYLKKASY*
CYP4T5 Fugu rubripes (pufferfish)
No accession number
Scaffold_8637
78% to 4T2
508 MEITRALVVLGWSHFYQLLALFCLAIVLYKLTVLLMLKRALIRNFESFPGPPGHWLFGNILE 693 (0)
902 FKQDGNDLDKLVKFGQKYPYCFPLWFGPFVCFLNIHHPEYVKTILAST 1045 (1)
1142 EPKDDLAYSFIQNWI 1186 (1)
1291 GNGLLVSQGQKWFRHRRLLTPGFHYDVLKPYVKLMAHSTKTML 1419 (0)
1673 DKWESYAKTNKPLEVFEYVSLMTLDTILNCAFSYDSNCQTER 1798 (2)
2267 KNTYIKAVYELSNLINLRFRIFPYHNDLIFYLSPHGFRYRKACMVAHSHT 2416 (1)
2521 EEVIKKRREALKKEKELERIQAKRNLDFLDILLFAK 2638 (0)
3171 DENQQGLLDEDIRAEVDTFMFEGHDTTASGISFLLYNLACHPKHQKLCRKEIMQVLHGKDTMDW 3362 (2)
3457 EDLNKIPYTTMCIKESLRMHPPVPGISRKTTKPITFFDGRTLPA 3588 (1)
392 ESRIGTSVFGIHRNASLWENPNV 457 (1) this exon from Fugu LPC.11421.x1
fdhwrflpenvskrsphafvpfsagpr this exon from 4T2 Dicentrarchus labrax
NCIGQNFAMNEMKVVIAMTLLKYELLEEPTLKPKIIPRLVLRSLNGIHIKIKNANQN*
CYP4T5 Tetraodon nigroviridis (freshwater puffer)
~84% to CYP4T5 fugu (ortholog)
lower case is from fugu
MEKTKALIELGWSQAHQLFVLFCVFVVLYKLTVLLVQKRALIQNFELFPGPPGHWLFGNVXX (0)
FKQDGNDLDKMVKFGQQYPYAFPLWFGPFVGFLNIHHPEYVKTILGST (1)
EPKDDLAYRFLQDWI (1)
GKGLLVTEGQKWFRHRRLLTPGFHYDVLKPYIKLIADSTKTML (0)
DKWENYAKTNKPFELFEYVSLMTLDSILKCAFSYDSDCQTKR (2)
kntyikavyelsnlinlrfrifpyhndlifylsphgfryrkacmvahsht (1)
eevikkrrealkkekeleriQAKRNLDFLDILLFAK (0)
DENQQGLSDEDIRAEVDTFMFEGHDTTASGISFILYNLACHPEHQKxCREEILQVLNGKDTMDW (2)
EDLSKIPYTTMCIKESLRLHPPVPGISRKTTKPITFFDGRTLPA (1)
GTRIGTSVFGIHRNATVWENPTV (2?)
NCIGQTFAMNEIKVVIAMTLKKYELMEEPTMKPKIIPRVVLRSLNGIHIRIKDVK*
CYP4T6 Xenopus laevis (African clawed frog)
SwissProt Q6AZQ1 (revised, added lower case seq)
91% to CYP4T6 X. tropicalis (ortholog)
MASGLWKVLSSSWLPVNVAQIGQFAILLCVVLLVLKACALYSRGRKFTAALTPFPGPPS
HWLYGHVNQFRRDGKDLDRLMVWAKKYPNAFPLWIGKFFGTLIITHPEYAKLVFGRPDP
KTSTGYSFLIPWIGKGLLVLSGDTWFQHRRLITPGFHYDVLKPYVGLISDSTKIMLDKL
DAFSNKDEPVELFQHVSLMTLDSIMKCAFSYQSNCQTDIDNDYIQAVYDLSWLTQQRIR
TFPYHSNLIYYLSPHGFRFRKACRIAHLHTDKVIGQRKKLLESKEELEKVQKKRHLDFL
DILLCAKDENGQRLSDEDIRAEVDTFMFEGHDTTSSGISWILHCMATHPEHQQKCQEEI
NEVLGERQTMEWDDLNRIPYTTMCIKESLRLYPPVPSVSRELAKPITFHDGKSLPAGIL
vslqiyaihrnpnvwkdpe
IFDPLRFSPENSSKRHSHAFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELLPDLSK
PPLKLPQLVLRSKNGIHVYLKKAS
CYP4T6 Xenopus laevis (African clawed frog)
AB114056 SwissProt Q766Y9
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
Second of three sequences submitted
76% to 4T3, 77% to 4T4, 72% TO 4T7 (PCR from I-helix to heme)
94% to CYP4T6 Xenopus tropicalis, ortholog
2 aa diffs to SwissProt Q6AZQ1 CYP4T6
TSSGISWILYCMATHPEHQQKCQEEINEVLGERQTMEWDDLGRI
PYTTMCIKESLRLYPPVPSVSRELAKPITFHDGKSLPAGILVSLQIYAIHRNPNVWKD
PEIFDPLRFSPENSSKRHSHAFVPFA
CYP4T6 Xenopus tropicalis (Western clawed frog)
NM_001017348.2
55% to 4B1 human, 73% to DR860523.1
79% to CYP4T3 of Xenopus laevis
Called CYP4T9 on Xenopus pages
MASTLWKALSSPWLSVNIYQIGQFVALLCVVLLLLKAYALYSRG
RRFAAALVPFPGPPAHWLYGHVNQFRRDGKDLDRLMVWVNKYPNAFPLWIGKFFGTLI
ITDPDYAKVVFGRSDPKTSTGYNFLVPWIGKGLLILSGNTWFQHRRLITPGFHYDVLK
PYVSLISDSTKIMLDELDVYSNKDESVELFQHVSLMTLDSIMKCAFSYHSNCQTDKDN
DYIQAVYDLSWLTQQRIRTFPYHSNLIYFLSPHGFRFRKACRIVHLHTDKVIGQRKKL
LESKEELEKVQKKRHLDFLDILLCSKDENGQGLSHEDLRAEVDTFMFEGHDTTSSGIS
WILYCMATHPEHQQKCREEISEALGERQTMEWDDLNRMPYTTMCIKESLRLYPPVPSV
SRELAKPITFHDGRSLPAGMLVSLQIYAIHRNPNVWKDPEIFDPLRFSPENSSKRHSH
AFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELSPDLSKPPLKQPQLVLRSKNGIH
VYLKKAS
CYP4T7 Xenopus laevis (African clawed frog)
SwissProt A1L2K6
MASNVLFGLFPTQLYSWAASLCLLLVLYKATQLYLRRRFLLTAFSSFPGPKCHWLYGNA
LQFLQVGKELDLILKWAQVYPYGVSMWLGNFHAALFLTHPDYAKAILARQDPKDETAYK
YIVPWIGEGLLVLSGPKWFQHRRLLTPGFHYDVLKPYVTLMSNCTRVMLDKWDKLMPNE
KTVELFHHVSLMTLDTIMKCAFSYNSSCQNNRDNSYIKAVYELSYLLDQRSRFFLYHND
VIFYLSPLGFRFRRALTVAHQHTDKVIKHRKQSLMNETELDKIKQKRHLDFLDILLCAK
DENGKGLSDKDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQHKCREEIRELLGDR
ETMEWGDLGQMPYTTLCIKESIRLYPPVPTIGRRLSKPITFCDGRSLPEGTEVLTSIYA
INRSPSVWNDPEVFDPLRFSPENSDNRHSHAFVPFSAGARNCIGQNFAMNEMKVAVALT
LQRYELFPDPDNEPQVIPQVVLRSLNGIHIKIRRVEKEKNKKGM
CYP4T7 Xenopus laevis (African clawed frog)
AB114057, SwissProt Q766Y8
Yoshiaki Fujita and Hiroaki Ohi
Submitted to nomenclature committee 7/1/2003
Third of three sequences submitted
74% to 4T3, 71% to 4T4, 72% to 4T6 (PCR from I-helix to heme)
1 aa diff to CYP4T7 A1L2K6
TASGISWILYCMAKYPEHQKKCREEIRELLGDRETMEWGDLGQM
PYTTLCIKESIRLYPPVPTIGRRLSKPITFCDGRSLPEGTEVLTSIYAINRSPSVWND
PEVFDPLRFSPENSDNRHSHAFVPFS
CYP4T7 Xenopus tropicalis (Western clawed frog)
scaffold_1:2712980-2727232,
83% to CYP4T7 X. laevis
MASNILFGLFPAQLYSWAASLCLLLVLYKATQLYLKRRFLVAALSPFPGPKSHWLYGNAHE (0)
FFQVGKELDLILRWAQVYPYGVSMWLGNFHAALFVTHPDYAKAILGRQ (1)
EPKDDTAYKYLVPWI (1)
GKGLLVLSGPKWFQHRRLLTPGFHYDVLKQYVSLMSDCTRDML (0)
DKWDKLMPNEKSIELFHHVSLMTLDTIMKCAFSYNSSCQNNR
DNEYIKAVYELSYLVYERSSFFPYHNDVIFSLSPLGFRFRKALSIAHQHT (1)
DKVIKHRKESLINETELDKISQKRHLDFLDILLFAK (0)
KDENGKGLSDEDLRAEVDTFMFAGHDTTASGISWILYCIAKYPEHQQKCREEITELLGDRETMEW (2)
GDLGQIPYTTSCIKESLRLYPPVPIIGRRLSKSITFSDGRSLPE (1)
GSVIFINIFCIHRNPTVWKDPE (0)
VFDPLRFSSENSSKRHSHAFVPFAAGPR (2)
NCIGQNFAMNELKVAVALTLNRYELSPDLSKAPLKSPQLVLRSKNGIHVYLKKASY*
CYP4T8 Danio rerio (zebrafish)
BC056734, NM_199216, CF943677
AI959112 fd24f08.y1 AI558878 fb67e05.y1
64% to 4T5 fugu
MLLYGISPFVLSVNHVFALIFLACLLTVVKLLIVRRKGVKTMER
FPGPPAHWLFGHVKEFRQDGHDLEKIVKWMELYQFAFPLWFGPSLAVLNIHHPSYAKT
ILTTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLTPGFHYDVLKPYVKLISDS
TKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFD
LCHLVNLRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKRKEVLKMEEEQG
IVKNRRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLAC
NPEHQEKCRQEIQQALDGKDTLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKLTKPL
TFFDGRTVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENAANRSPHAFVPFSAG
PRFVTRSV
CYP4T9X Xenopus tropicalis (Western clawed frog)
DR860523.1 CX967683.1 DT412234.1 DR834559.1
Called CYP4T8 on Xenopus pages
93% to CYP4T3v2 of Xenopus laevis
best match in human = 4B1 55%, possibly a 4B1 ortholog
note: this sequence is identical to CYP4T3 X. tropicalis
MWNTLVWQQVA
ALLCLLAVLLKATQLYLSQKRQENIFKQFPGPPRHWLLGNVDQIRRDGKDLDLLVNWTHK
NGGAFPVWFGNFSSFLFLTHPDYAKVIFGREEPKSSISYDFLVPWIGKGLLVLTGPKWFQ
HRRLLTPGFHYDVLKPYVNLISKCTTDMLDNWEKLITKQKTVELFQHLSLMTLDSIMKCA
FSYDSNCQKDSNNAYIKAVFDLS
YVANLRLRCFPYHNDTVFYLSPHGYRFRKACRITHEHTDKVIQQRKESMKLEKELEKIQQ
KRHLDFLDILLFARDEKGHGLSDEDLRAEVDTFMFEGHDTTASGISWILYCMAKYPEHQQ
KCREEIKEVLGDRQIMEWEDLGKIPYTNMCIKESLRMYPPVPGVARQLRNPVTFFDGRSV
PAGTVIGLSIYAIHKNPAVWEDPEVFNPLRFSPENSANRHSHAFLPFAAGPRNCIGQNFA
MNEMKVAVALTLNRFHLAPDLENPPIRIPQLVLKSKNGIHVHLTKVQ*
CYP4T10X Xenopus tropicalis (Western clawed frog)
NM_001017348.2 from refseq database
Called CYP4T9 on Xenopus pages
55% to 4B1 human, 73% to DR860523.1
79% to CYP4T3 of Xenopus laevis
this sequence is identical to CYP4T6
MASTLWKALSSPWLSVNIYQIGQFVALLCVVLLLLKAYALYSRG
RRFAAALVPFPGPPAHWLYGHVNQFRRDGKDLDRLMVWVNKYPNAFPLWIGKFFGTLI
ITDPDYAKVVFGRSDPKTSTGYNFLVPWIGKGLLILSGNTWFQHRRLITPGFHYDVLK
PYVSLISDSTKIMLDELDVYSNKDESVELFQHVSLMTLDSIMKCAFSYHSNCQTDKDN
DYIQAVYDLSWLTQQRIRTFPYHSNLIYFLSPHGFRFRKACRIVHLHTDKVIGQRKKL
LESKEELEKVQKKRHLDFLDILLCSKDENGQGLSHEDLRAEVDTFMFEGHDTTSSGIS
WILYCMATHPEHQQKCREEISEALGERQTMEWDDLNRMPYTTMCIKESLRLYPPVPSV
SRELAKPITFHDGRSLPAGMLVSLQIYAIHRNPNVWKDPEIFDPLRFSPENSSKRHSH
AFVPFAAGPRNCIGQNFAMNEMKVAVALTLKRFELSPDLSKPPLKQPQLVLRSKNGIH
VYLKKAS
CYP4T11 Gobiocypris rarus (a rare minnow)
GenEMBL EU593896 (not available yet on May 16, 2008)
Jiayin Dai
Submitted to nomenclature committee 4/2/2008
87% to zebrafish CYP4T8
MQLYEIFPLNLEALSINHAFPLALLVCLVIVDRLMTMKRRGMRTMEPFPGPPAHWLFGHVKEFHQDGHDLEKIIMWCEQYPFAFPLWFGPSLSILNIHHPSYVKTILTTTEPKDDYAYKFFIPWLGDGLLVSAGQKWFRHRRLLTPGFHYDVLKPYVKLISDSTKVMLDKWELYAKSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDSGTNPYIQAVFDLCHLVNLRFRVFPYHSKAIFHLSPHGYKFRKAAGMAHNHTAEVIRKRKEVLKMEKEQGIVKNKRYLDFLDILLSARDENQQGLSDEDIRAEVDTFMFEGHDTTASGISWIFYNLACNPEHQEKCREEILRALDGKDTLEWEDLNKIPYTTMCIKESLRLCPPVPGISRKLTKPLTFFDGRTVPEGCTIGVSIYGIHLNATVWENPYVFDPLRFLPENTAKRSPHAFVPFSAGPRKGKFFKELFPVQS
CYP4T12 medaka
UCSC Browser chr16:19969746-19976887 (+) strand, Oct. 2005 assembly
68% to 4T1 zebrafish, 52% to CYP4B1 human,
51% to CYP4A11
MFAAGLTEALFG
FQLTWLHIHVAFGALCIIVIVHKLTLLTATRKSLLRDVEAFPGPPGNWLFGH (0)
LAQDGTDLERGLKWGEQYPYAFPMWFGPSVCFLNIHHPDYAKTILTTT (1)
EPKDDLAYRFIESWI (1)
GNGLLVSKGQKWFRHRRLLTPGFHYDVLKHYVNLMSESAQVML (0)
DKWESYANTSETFELFEHVSLMTLDSILKCAFSHNSNCQREG (2)
ETNKYIKAVYELSDLISFRMRTFPYHSDLIFYLSPHGFRHRRACKVAHSHT (1)
QVIRKRKEALKEETESSRKRNLDFLDILLFAK (0)
DENQQGLSDEDIRAEVDTFMFEGHDTTASGISFILYCLASHPEHQKICRNEVMEA
LDGKDTIEW (2)
EDLNKIPYTTMCIKESLRLYPPVPGISRKLTKPITFFDGRTLPA (1)
GFKVGTSVFGIHRNATVWENPE (0)
VFDPLRFLPENVSKRSPHAFVPFSAGAR (2)
NCIGQNFAMNEMKVVIAMTLKKYQLIEEPSLKPRIIPRLVLRSLNGIHIKIKPVEAQK*
CYP4T13P medaka
UCSC Browser chr16:19947384-19950469 (+) strand, Oct. 2005 assembly
missing some parts, 95% to CYP4T12 medaka, upstream by 19 kb
MFAAGLTEALFG
FQLTWLHIHVAFGALCLIVIVHKLTLLTATRKSLLRDVEAFPGPPGNWLFGH (0)
PTQDTTNLERGLKWGEQYPYAFPMWFGPSVCFLNIHHPDYAKTILTTT (1)
EPKDDFGYMFIESWI (1)
GNGLLVSKGQKWFRHRRLLTPGFHYDVLKHYVNLMSESAQVML (0)
(missing 5 exons)
GFKVRTSVFGIHRNATVWENPE (0)
FDPLRFLPENVSKRSPHAFVPFSAGAR (2)
(seq gap)
CYP4T14 Lancelet (Branchiostoma floridae)
UCSC Browser chrUn: 340141881-340149534 March 2006 assembly
55% to 4T1 zebrafish, 54% to 4T12 medaka
gene order: KIF2A CYP4T14 PTCH1 MKNK1
MTPFMNFCLLILSTTTMGSIPAQWLPHWEA
GYLRTACLTVLVAVAVQLVFRFLRALLWKRYIQKVLAPFPGQPAHWLFGHMRE (0)
VRPDETGFTIVPQWAAKFKFAFPLWIGPFRVVLSLVHPDYIKEINSP (1)
VNDLHTILSIFFTEPKDRVSYAWLKPWI (1)
GDGLLVSEGQKWFRNRRLLTPGFHFDVLKPYVKVFSECTNIML (0)
DRWADLAPGTPVEMFHYASAMTLDSLMRCALSVRSDCQRDSDGSPYIRA
VYDLTKC
VVERGRFPPFHIPLIFHLSPTGFR ()
FRKACKTAHDFSDEVIRKRRTELQQQGCHQNDTANSSE
DGGKKRYLDFLDILLQAR (2)
DEDGKGLSEREIRDEVDTFMFEGHDTTASGVSWILY
NLAKHPACQDRCRAEVDAVLQGRAEVKW (2)
EDLSKLPYTTMCIKESLRMHSPVPGVTRLTTQPHTFPDGRSIPA (1)
GVSVSIGVHSLHHNIHVWGDN (0)
EFDPERFSPENSKGRSSHAFIPFSAGSR (2)
NCIGQHFAMNELKVTVALTLQRYRLELDETRPPYR
VARLITRTRDGLWLKVYPRGADN*
CYP4T15 Xenopus laevis (African clawed frog)
EST BG018182 de66c08.x1
64% to CYP4T6 Xenopus laevis (African clawed frog)
no X. tropicalis ortholog is found
IYHLVPLDRREVAIPILSMIGTSSAAGILVSLKTYAIHENPDVSKDPEIFDHLRWSPESS
CKRHSHAFVPSAAGPRKCIVQNFAMN
DMKVDGTVSLTRY
4U Subfamily
CYP4U1 Coptotermes acinaciformis (termite)
GenEMBL AF046010
Patrick Falckh
C4-8_9-D
CYP4U2 Coptotermes acinaciformis (termite)
GenEMBL AF046011
Patrick Falckh
C4-8_9-F
CYP4U3 Reticulitermes flavipes (termite)
No accession number
Michael Scharf
Submitted to nomenclature committee Feb. 19, 2009
Clone name RfP4501V1 (full length)
99% to CYP4U3v1 (only 1 aa diff)
98% to 4U3v2 (only 2 aa diffs)
52% to CYP4U1 Coptotermes acinaciformis (termite),
69% to CYP4U2 partial seq
47% to CYP4BN6 Tribolium
CYP4U3v1 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #1v1
67% to 4U2 I-helix to heme, 98.1% identical to CYP4U3v2
CYP4U3v2 Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #1v2
68% to 4U2 I-helix to heme, 98.1% identical to CYP4U3v1
CYP4U4P Reticulitermes flavipes (termite)
No accession number
Michael E. Scharf
Submitted to nomenclature committee 10/7/05
Clone name #8 (pseudogene)
78% to 4U1 I-helix to heme, one stop, 2 frameshifts
4V Subfamily
CYP4V1 Oncorhynchus mykiss (rainbow trout)
GenEMBL AF046012
Patrick Falckh
OM4-8_9
CYP4V2 human
GenEMBL AC012525
formerly CYP4AH1 AC012525 Homo sapiens chromosome 4
MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGR
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEG
ILTSSKQIDKSSMYKFLEPWLGLGLLT
STGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIIC
ETAMGKNIGAQSNDDSEYVRAVYR
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSV
IAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE
GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDV
KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSED
YFLTAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQG
RHPYAYVPFSAGPRNCIG
QKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER*
CYP4V2 Pan troglodytes (chimpanzee)
XM_001165629.2
97% to human two short regions do not match
MAGLWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVATYARKW QQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVAL YNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILE DFLDIMNEQANTLVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSE YVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHTFTNSVIAERANEM NANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTT AAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLF PSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPKNAQ GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILR
PSNGIWIKLKRRNADER
CYP4V2 Macaca mulatta (rhesus monkey)
95% to human 4V2
MAGIWLGLVWQKLLLWGAASAVSLAGASLVLSLLQRVASYVRKWQQMRPIPTVARAYPLV
GHALLMKRDGR (1)
EFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE (0)
VILTSSKQIDKSSMYKFLEPWLGLGLLTS (2)
TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHVNQEAFNCFVYITLCALDIIC (1)
ETAMGKNIGAQSNDDSEYVRAVYR (2)
MSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLKILHAFTNN (0)
VIAERANEMNVDEDCRGDGRDSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFE (0)
GHDTTAAAMNWSLYLLGSNPEVQKKVDHELDDVF (1)
GRTDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV (1)
AGYRVLKGTEAV
IIPYALHRDPRYFPNPEEFRPERFFPENAQGRHPYAYVPFSAGPRNCI (1)
GQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPTNGIWIKLKRRNADE 1551
CYP4V2 Bos taurus (cow)
See cattle page for details
MLAPWLLSVGPKLLLWSGLC
AVSLAGATLTLNLLKMVASYARKWRQMRPVPTIGDPYPLVGHALMMKSDARDFFQQIIDFTEECR
HLPLLKLWLGPVPLVALYNAETVEVILSSSKHIEKSYMYKFLEPWLGLGLLTSTGNKW
RSRRKMLTPTFHFTILEDFLDV
MNEQANILVTKLEKHVNQEAFNCFFYVTLCTLDIICETAMGKNIGAQRNDDSEYVRAVYR
MSDSIHQRMKMPWLWLDLIFYMFKNGREHRRSLKIVHDFTNNVITERANEMKRHEEGTSN
DKEKDFPPRKTKCRAFLDLLLNVT
DDQGNKLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGWYPEVQQKVDTELEEVFGKS
DRPVTLEDLKKLKYLDCVIKESLRLFPSVPFFARNLTEDCEVAGHKMVQGCQVIIVPYAL
GSSRDPKYFPDPE
EFKPERVFPENLKGRHTYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKRE
ELGLAGELILRPSNGIWIKLKRRNTDES*
CYP4V2 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
Two partial sequences called CYP4V2_1 and CYP4V2_2
Are different parts of the same gene
Ortholog of human CYP4V2
CYP4V2 Sus scrofa (pig)
CB473254.1, DB791600.1
lower case = cow seq
mlapwllsvgpklllwsglc
avslagatltlnllkmvasyarkwrqmrpvptigdpyplvghalmmksdardffqqiidfteecr
hlpllklwlgpvplvalynaetvevilssskhieksymyk FLEPWLGLGLLTST
1 GNKWRSRRKMLTPTFHFTILEDFLDVMNEQATILVTKLEKHVNQEAFNCFF 153
153 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRVSDSIHRRMKAPWLWFDFLYFMFK 329
330 DGQEYRKSLKILHNFTSNVITERASEMKRDEERSHDDKDIPPHKNKCKAFLDLLLNVTDD 509
510 KGNKLSHEDIREEVDTFMFE 557
ghdttaaainwslyllg
FYPEVQKKVDNELDEVFGKSDRPATLEDLKKLKYLECVIKESLRLFPS
3 VPFFARSINEDCEIAGHKIVKDSQVIIVPYALHRDPRYFPNPEEFRPERFFPENSKGRH 179
180 SYAYVPFSAGPRNCIGQKFAIMEEKTILSCILRHFWVESNQKREELGLAGEPILRPTNG 356
IWIKLKRRNTDES*
CYP4V3 mouse
No accession number
Yoshiaki Fujita, Hiroaki Ohi, Katsuya Kase
Submitted to nomenclature committee July 5, 2000
Clone name KK-1
80% identical to 4V2 human
Cyp4v3 mouse
GenEMBL AB056457 28 feb 2001 81% to 4v2
MLWLWLGLSGQKLLLWGAASAVSLAGATILISIFPMLVSYARKW
QQMRSIPSVARAYPLVGHALYMKPNNAEFFQQLIYYTEEFRHLPIIKLWIGPVPLVAL
YKAENVEVILTSSKQIDKSFLYKFLQPWLGLGLLTSTGSKWRTRRKMLTPTFHFTILE
NFLDVMNEQANILVNKLEKHVNQEAFNCFFYITLCALDIICETAMGKNIGAQSNNDSE
YVRTVYRMSDMIYRRMKMPWLWFDLWYLVFKEGRDHKRGLKCLHTFTNNVIAERVKER
KAEEDWTGAGRGPIPSKNKRKAFLDLLLSVTDEEGNRLSQEDIREEVDTFMFEGHDTT
AAAINWSLYLLGTNPEVQRKVDQELDEVFGRSHRPVTLEDLKKLKYLDCVIKETLRVF
PSVPLFARSLSEDCEVGGYKVTKGTEAIIIPYALHRDPRYFPDPEEFRPERFFPENSQ
GRHPYAYVPFSAGPRNCIGQKFAVMEEKTILACILRQFWVESNQKREELGLAGDLILR
PNNGIWIKLKRRHEDDP
Cyp4v3 rat
CYP4V4a Xenopus laevis (African clawed frog)
87% to CYP4V4 X. tropicalis, 83% to CYP4V4b X. laevis
presumed ohnolog to CYP4V4b
MEFKGDVQPLVWMAAAVVLLTLLAFSALPPLLDYFRKWKLMRPIPGPGPNYPLVGDALF
LKPNGGDFFLQMCEFTELFRVEPLIKLWIGPIPFVIVYHADTVEPILSTSKHMDKSYAY
KFLHPWLGQGLLTSTGEKWRSRRKMITPTFHFAILSEFLEVMNEQSKVCVEKLQKHVDG
ESFNCFMDVTLCALDIISETAMGRKIQAQNNRDSEYVQAIYKMSDIIQRRQKMPWLWLD
FIYAHLKDGKEHNKNLKNLHAFTDKAILERAEELKKTEAKKGHFDSEPESEKPKKRSAF
LDMLLMATDDAGNKLSYKDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKE
LDEVFGKSDRPVTMDDLKKLRYLEAVIKEALRIYPSVPFFARTITEDCIIRGFHVPKGV
NVVIIPYALHRDPEYFPEPEVFRPERFFSENASGRNPYAYIPFSAGLRNCIGQRFALME
EKVVLSSILRNYWVEATQKREELCLLGELILRPQDGMWIKLKNRKTASSA
CYP4V4b Xenopus laevis (African clawed frog)
NM_001172180
Yoshiaki Fujita, Hiroaki Ohi, Katsuya Kase
Submitted to nomenclature committee July 5, 2000
Clone name XL-4
58% identical to 4V2 human
82% to CYP4V4 X. tropicalis
CYP4V4b is a presumed ohnolog to CYP4V4a
MELKGDVNVLLWTAVIVVLLTLLVFSALPVLLDYVRKCKVMRLI
PGPGPNYPLVGDALLLKSDAREFFLQMCEFAEDFRSEPLLKLWIGPIPFLIVYHADTL
EPFLSTSKHVDKAYLYKFLHPWLGKGLLTSTGEKWRIRRKMITPTFHFAILSEFLEVM
NEQSNVLVEKLQKHADGESFDCFIDVTLCVLDIISETAMGRKIEAQSNKDSEYVQAIY
KMADFIQNRQTKPWLWSDSLYAYLKEGKEHNKTLNILHTFTDKAILERAEELKKMEVK
KGDSDPESEKPKKRSAFLDMLLMATDDAGNKMSYKDIREEVDTFMFEGHDTTASALNW
TLFLLGSHPEAQRQVHKELDEVFGKSDRPVTMDDLKKLRYLEAVIKESLRIFPPVPMF
GRTVTEDCTVRGFKVPKGVNIIVITYSLHRDPEYFPEPEEFRPERFFPENASGRNPYA
YIPFSAGLRNCIGQRFALMEEKVVLSSILRKYWVEATQKRDECLLVGELILRPQDGMW
IKLKNRETASSA
CYP4V4 Xenopus tropicalis (Western clawed frog)
CX972921.1 AL876066.2 CR409635.1 DT527908.1
scaffold_95:1665309-182117 (+) strand adjacent to CYP4V9
best hit to CYP4V2 in ESTdb X.tropicalis
best match in human = 4V2 62%, a 4V ortholog
82% to CYP4V4b X. laevis, 87% to CYP4V4a X. laevis
MELGGEVHLLVWVAAAVVLLTLLALSILPALQDYVRKRRILKPIPGPGPNYPLIGDALFLKN
NGGDFFLQICEYTESYRLQPLLKVWIGTIPFIVVYHADTVEPVLSSSKHMDKAFLYKFLHPW
LGKGLLTSTGEKWRSRRKMITPTFHFAILSEFLEVMNEQSKILVEKLQTHVDGESFDCFM
DVTLCALDIISETAMGRKIQAQSNRDSEYVQAIYKMSDIIQRRQKMPWLWLDFLYAHLRD
GKEHDKNLKILHSFTDKAILERAEELKKMGEQKKEHCDSDPESDKPKKRSAFLDMLLMAT
DDAGNKMSYMDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKELDEVFGKSD
RPVTMDDLKKLRYLEAVIKESLRIYPSVPLFGRTVTEDCSIRGFHVPKGVN
VVIIPYALHRDPEYFPEPEEFRPERFFPENASGRNPYAYIPFSAGLRNCIGQRFALMEEK
VVLSSILRNYWVEASQKREELCLLGELILRPQDGMWIKLKNRETAPTA*
CYP4V5 Fugu rubripes (pufferfish)
No accession number
Scaffold_485
60% to 4V3 over 513 aa
exon 5 starts with ETAM seen in many Drosophila 4 fam. and C. elegans sequences
36037 MADLLGGFTLPLLGASVFVAALTCFTYRMLSDYLHKWFQMKPIPELEGTYPLIGNALQFKPNAG 36222 (1)
36309 DFFNQIVEYTRENYHRPLFKIWVGPVPFVVLFHPETVE (0)
36504 PVLTNAVHMEKSYSYSFLHPWLGTGLLT 36587 (2)
37012 STGPKWRRRRKMLTPTFHFSILADFLEVMNEQAEILVEKLDQQAGKGPFNCFSYVTLCALDIIC 37203 (1)
ETAMGKKIYAQSNSESEYVKCVSK 37380 (2)
37458 MSDIISRRQRTPWFWPNFAYYSIGDGREHDSTLKVLHSFTYK (0)
37661 VITERAENVSSVESDSDSDHGRKKRQAFLDMLLKTTDEDGNKMSHRDIQEEVDTFMFR (0)
37906 GHDTTAASMNWVLHLMGSHPEAQSKVHQELQEVF (1)
38199 GESNRPITTEDLKKLKYLESVIKEALRLFPSVPFFARSLGEDCHI 38321 (1)
38530 NGFKVPKGANAVIITYALHRDPRYFPEPEEFRPERFLPENSVGRPPYAYLPFSAGLRNCI 38724 (1)
38802 GQRFALIEEKVVLASILRKFNVEACQKREELRPVGELILRPEKGIWIKLEKRKPLIPPS* 38981
CYP4V5-like fragment Fugu rubripes (pufferfish)
FS:S000209 Scaffold_209 52% to 4V5
102980 DSTIAGFKVPKGHGAIYVSHAVHRDPDVFQQPDSFLPERW 103099
CYP4V5 Tetraodon nigroviridis (freshwater puffer)
90% TO FUGU CYP4V5 (ortholog)
MADLPGSLTLPLLGASVFVAALTCLTYWMLGEYLHKWFTMKPIPQLQGTYPLIGNALLFKPNAG (1)
DFFNQIVEYTREFSNYPLFKIWVGPVPFVVLFHPETVE (0)
PVLNNAVHMEKSYSYSFLHPWLGTGLLTS (2)
TGPKWRHRRKMLTPTFHFSILTDFLEVMNEQAEILVEKLELQAGKGPFNCFSHITLCALDIIC (1)
ETAMGKKIYAQSNSESEYVKCVYK (2)
MSDIISRRQRTPWFWPDFVYYSFGDGREHDSTLKVLHSFTYK (0)
VITERSENISCVESDRDSDHGRRKRQAFLDMLLKTTDEDGNKMSHGDIQEEVDTFMFR (0)
GHDTTAASMNWVMHLLGSHPKAQSKVHQELQEVF (1)
GESDRPTNIEDLKKLKYLECVIREALRLFPSVPFFARSLGEDCHI (1)
NGFKVPKGANAIIITYGLHRDPRYFPDPEEFRPERFLPENSVGRPPYAYLPFSAGLRNCI (1)
GQRFALMEEKVVLASILRRFTVEACQTREELRPVGELILRPEKGIWIKLEKRKPLVLSS*
CYP4V6 Balaenoptera acutorostrata (Minke whale)
AB290012
Iwata Hisato
submitted to nomenclature committee 1/6/05
82% to CYP4V ortholog of cow and 76% to 4V2 human
MLALWLLSVGQKLLLWGGLCAVSLAGAILTLNLLRMAASYAWTW
QRMRAVPTLEGAYPFLGHALLLKPDARDFFQQMIQYTEEHRHLPLLKLWLGPIPVVFL
YNAENVEVILTSSKHIDKSYMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILE
DFLDVMNEQANILVNKLEKYVNQEAFNCFSYITLCALDIICETAMGKNIGAQSNNDSE
YVQAVYRMSDSIHQRMKMPWLWLDLLFFIFKDGWEHKRSLKILHNFTKNVITERANEM
KRHEEGRSNDKDFPPHNNKRRGFLDLLLNVTDDQGNKLSYEEIREEVDTFMFEGHDTT
AAAINLSLYLLGSYPEVQQKVDNELEEVFGRSDRPATLDDLKKLKYLECVVKESLRLF
PSVPFFARNLNEDCEVAGYKIVKGSQVIIMPYALHRDQRYFPNPEEFKPERFFPENSK
GRHSYAYVPFSAGPRNCIGQKFAMMEEKTILSCILRHFWVESNQKREELGLAGELILR
PSNGIWIKLKRRNTNES
CYP4V7 Danio rerio (zebrafish)
See zebrafish page for seq
CYP4V7-ie6b Danio rerio (zebrafish)
See zebrafish page for seq
CYP4V8 Danio rerio (zebrafish)
See zebrafish page for seq
CYP4V9 Xenopus tropicalis (Western clawed frog)
scaffold_95:133361-146085 (+) strand adjacent to CYP4V4
93% to CYP4V4 X. tropicalis, 90% to CYP4V4a X. laevis
82% to CYP4V4b X. laevis
MELRGEVHLLVWVAAAVVLLTLLALSILPALQDYVRKWKLMKPIPGPGPNYPIVGDALFL
KPNGGDFFLQMCEFTESFRSEPLIKIWIGPIPFIIVYHADTVEPILSYSKHMDKAYSYKF
LHPWLGKGLLTSTGEKWRSRRKMITPTFHFAILSEFLEVMNEQSKILVEKLQKHVDGESF
NCFMDVTLCALDIISETAMGRKIQAQSNRDSEYVHAIYKMSDIIQRRQKMPWLWLDFFYA
YLKDGKEHDKNLKILHAFTDKAILERAEELKKMGEQKKEHCDSDPESDKPKKRSAFLDML
LMATDDAGNKMSYMDIREEVDTFMFEGHDTTAAALNWSLFLLGSHPEAQRQVHKELDEVF
GKSDRPVTMDDLKKLRYLEAVIKEALRIYPSVPFFARTVTEDCSIRGFHVPKGVNVVIIP
YALHRDPEYFPEPEEFRPERFFPENASGRNPYAYIPFSAGLRNCIGQRFALMEEKVVLSS
ILRNYWVEASQKREDLCLLGDLILRPQDGMWIKLKNRETAPTA
CYP4V10v1 Cyphoma gibbosum (cowrie, gastropod mollusc)
EU546250.1
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-1v1, formerly CYP4C49
CYP4V10v2 Cyphoma gibbosum (cowrie, gastropod mollusc)
EU546251.1
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-1v2, one small deletion and
1 aa diff compared to CYP4V10v1
CYP4V11 Orconectes limosus (crayfish)
GenEMBL AF091117
Chantal Dauphin-Villemant
submitted to nomenclature committee
this is a tentative assignment, this sequence may require its own
subfamily
50% identical to 4C1 over full length, 58% identical over C-terminal
formerly CYP4C15
CYP4V12 Penaeus setiferus (shrimp)
GenEMBL AF072854
Mark Snyder
submitted to nomenclature committee
formerly CYP4C16
CYP4V13 Haliotis rufescens (red abalone)
GenEMBL AF072853
Mark Snyder
submitted to nomenclature committee
formerly CYP4C17
CYP4V14 Homarus americanus (lobster)
GenEMBL AF072852
Mark Snyder
submitted to nomenclature committee
formerly CYP4C18
CYP4V15 Cherax quadricarinatus (crayfish)
No accession number
Moshe Tom
Submitted to nomenclature committee May 4, 2000
Clusters with the other crayfish sequence 4C24 on trees
formerly CYP4C29
CYP4V16 Carcinus maenas (shore crab)
GenEMBL AY328467
Kim Rewitz
submitted to nomenclature committee 6/18/2003
59.5% to 4C15
formerly CYP4C39
CYP4V17 Litopenaeus vannamei (Pacific white shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
58% to 4C39 shore crab, 64% to 4C32 Daphnia, 62% to 4C31 Daphnia,
49% to 4C25 Anopheles, 48% to 4C53 Daphnia, 47% to 4C3 Drosophila
Clone name Lv03
formerly CYP4C54
CYP4V18 Litopenaeus vannamei (Pacific white shrimp)
GU969106
Xichao Xia
Submitted to nomenclature committee June 10, 2010
71% to CYP4V16 Carcinus maenas (shore crab)
62% to CYP4V17 Litopenaeus vannamei (Pacific white shrimp)
This seq is not named correctly in Genbank. It is called CYP4C39.
This was due to the strong similarity to the old CYP4C39 that is now
named CYP4V16.
CYP4V19 Fenneropenaeus chinensis (fleshy prawn)
GenEMBL ACZ48687
Zhe Zhang
Submitted to nomenclature committee Oct. 28, 2010
58% to CYP4V16, 58% to CYP4V11
CYP4V20 Macrobrachium nipponense (fresh water shrimp)
GenEMBL JN704302
Wenfeng Wang
Submitted to nomenclature committee July 4, 2011
65% to CYP4V16 crab
CYP4V21 Orconectes limosus (crayfish)
no accession number
C. Dauphin-Villemant, M. Tom, M. Waterman and D. Bšcking
submited to nomenclature committee 6/15/99
formerly CYP4C24, 86% to CYP4V18
4W Subfamily
CYP4W1 Boophilus microplus (cattle tick)
no accession number
Crampton AL, Baxter GD, Barker SC
Identification and characterisation of a cytochrome P450 gene and
processed pseudogene from an arachnid: the cattle tick, Boophilus
microplus.
Insect Biochem Mol Biol 29, 377-84 1999
CYP4W2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W2-de10b11b Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4W7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
4X Subfamily
CYP4X1 human
GenEMBL BC028102
David Bell
submitted to nomenclature committee 12/30/97 revised 4/12/00
about 50% identical to CYP4A members
R56515, R53456, AA652746, AC026935
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQK
FIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQKFSPP
LLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVE
VYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFK
LSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDES
GSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSSIT
WDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNP
AVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRV
TPDPTRPLTFPNHFILKPKNGMYLHLKKL
CYP4X1 Pan troglodytes (chimpanzee)
XM_001162991.2
99% (2 aa diffs) to human
MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLR PFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTL LSRTDPKSQYLQKFSPPLLGKGLAALDGPKWFQHRRLLTPGFHFNILKAYVEVMAHSV KMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQTNSTHDPYAKAIFE LSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSLQAGVKQD NTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISWILYCLAL NPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPL TFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAG SRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLSEC
CYP4X1 Bos taurus (cow)
See cattle page for details
24776 MESSWLETHWARPFYLTLVFCLALGLLQAIKLYLQRQRLLRDLRLFPSPPTHWLYGHSK 24600
4386 LFKDGKMEILEKIVEKYPCAFPRWIGPFQAFLYIYDPDYAKTFLSRT (1)
DPKSNFLYKFMTASV
1563 GKGLVNLSGPKWSQHRRLLTPGFHFNTLKSFVEVMAQSVNIML 1435
NKWEKICGSQNTLLDIYEHINLMTLDVLMKCIFSWETNCQTDSSHDNYVKATSEGSNILMQR
LFNYFYHYDLIFKLSPLGHRLREVNKILHHHTDKIVKNRRNSLKDENKQTNTQKRKYRDF
LDIVLSAQAENDSFTDADLWSEVNTFMVAGHD
SVSAGISWLLYHLALYPEHQEKCREEIRAILGDGSSITWDQLSEM
SYTTMCIKESLRLAPPAVSISRQLSKPITFPDGRSLPAGMTVVLSIWGLHHNPAVWENPE
VFDPLRFSQECNKRHSHAYLPFSSGPRNCIGQNFAIAEIKVIVALI
LLRFQMRVEPTKPV
VFVPYIFIKPKKGIYLHLKKLP*
CYP4X1 Sus scrofa (pig)
DB802053.1 DB802658.1
MESSWLETHWARPLHLALVFCLALGLLQAVKLYLQRQRLLRDLRPFPSPPSHWFYGHQKI
IQNGGMETLGEITDKYPRAFPFWLGPFQAFFFIYDPDYAKTLLSRPDPKSNFLYKFMDPV
VGKGLLNLNGPKWFQHRRLLTPGLHLNALKSHVEIMAHSVNTMLGKWERICGTEDTLLEI
SAHVTLLTLDIIMKCVFGLETNCQINSTYDHYVKAVNEGSNLIFYRVYNFLYHHDIIFKF
SPKGHRFLELRKILHPYTAKIIQAGKNSLMNENQQGNTQKRKY
RNIFDIALSAQAENGDSFSDTDLRSEVNTFLLAGHETMTGGLT
WLLYHLALYPEHQERCREEIRSILGDGSSITWGQLGEMSYTTMCIKESLRLAPPVLSFSR
ELSKPITFSDGRSLPAGITVVCSIWGLHHNPAIWENPQVFDPLRFSQENNDKRHCYAYLP
FSAGPRNCVGQQFAMAELKAAVALILLRFSLTAEATRPLVSRPNIFLKPKNGLYLHLKKLP*
CYP4X1 Canis familaris (dog)
XM_539622.2
74% to CYP4X1 human
MESSWLETRWARPLYLAFAFCLALGLLQAIKLYLRRLRLLRDLC
PFPAPPTHWFYGHQKLLQDGKIEKLEELVEKYPCAFPYWVGPFQAFFYIYDPDYAKTF
LGRTDPKSKYLYKFLIPCLGNGLVNLEGSKWFQHRCLLTPGFNVNILKSYIKVMAHSV
NTMLGKWEKICGTQDTVVEVFEHINLMTLDVLMKCAFSQETNCQISSNHDLYVKTTFE
ASKINFYRLYSFLHHHDIIFKFSPQGHRLQELVKILHQYTEKVIQDRKKLLKDEKKHG
NTQKRKDQDYLDIILSAQAENGNSFSDTDLRSEVNTFILAGHDTMAGSISWLLYHLAL
NPEHQERCRQEIRGILRDRSSITWDQLGEMSYTTMCIKESLRLAPPIPSISRELSKPI
TFPDGRSLPAGITVVLSIWGLHHNSAIWENPKVFDPLRFSQENSDQRHTHSFLPFSAG
PRNCIGQHFAMVKLKVAIALILLHFKVSPDPTRPLVFLHQIVLKPKNGVHLHLKKLP
Cyp4x1 mouse
No accession number
Berthold Gottgens
Approx. 410 amino acids covered with some missing parts
66% identical to 4X1 human
Cyp4x1 mouse
GenEMBL AJ297131 runs from 112000 to 138000 on the minus strand
NT_039264.1, NT_039685.1
MEASWLETRWARPLHLALVFCLALVLMQAMKLYLRRQRLLRDLSPFPGPPAHWLLGHQK
FLQEDNMETLDEIVKKHPCAFPCWVGPFQAFFYIYDPDYAKIFLSRT
GRGLLNLDGPRWFQHRCLLTPAFHQDILKPCVDTMAHSVKVML
DKWEKMWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQIN
STYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQYT
EKIIQDRKKILKNQVKQDDTQTSQIFLDIVLSAQ
GKEDERAFSDADLRAEVNTFMWAGHDASAASISWLLYCLALNPEHQDRCRTEIRSILGDGSSITW
EQLDEMSYTTMCIKETLRLIPPVPSISRELSKPLTLPDGHSLPAG
MTVVLSIWGLHHNPAVWNDPK
VFDPLRFTKENSDQRHPCAFLPFSSGP
RNCIGQQFAMLELKVAIALILLHFQVAPDLTRPPAFSSHTVLRPKHGIYLHLKKL
CYP4X1 rat
no accession number
Johan Bylund and David R. Harder
submitted to nomenclature committee 9/26/01
91% identical to CYP4X1 mouse, 69% to 4X1 human
4Y Subfamily
CYP4Y1 Mytilus galloprovincialis (blue mussel)
no accession number
Mark Snyder
submitted to nomenclature committee
4Z Subfamily
CYP4Z1 human
GenEMBL AY262056 AJ131016 AC026935 161971-176942
ESTs H21976, H21977, H25577, H25624
Formerly named 4Z1 from a fragment renamed 4A20 then restored to 4Z1
Full length seq now available on genomic DNA
52% to 4A11 52% to 4X1
because the sequence is the same percent identity to
4A11 and 4X1 and this is less than 55%
and the sequence does not cluster with CYP4As on a tree
the earlier name of CYP4Z1 is being resurrected.
This seems to be a more accurate name.
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKE
FYPVKEFEVYHKLMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQDP
KSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSE
SVRMML
NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD
STLDYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT
EKVIQDRKESLKDKLKQDTTQKRRWDFLDILLSAKV
ENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSSITW
EHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPA
GITVFINIWALHHNPYFWEDPQV
FNPLRFSRENSEKIHPYAFIPFSAG
PRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVRQVVLKSKNGIHVFAKKV
CYP4Z1 Pan troglodytes (chimp)
XR_023310 10 aa diffs to CYP4Z1
MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLHQRRRWMIRALRLFPA PPAHWFYGHKEFYPVKEFEVYPELMEKYPCAVPLWVGPFTMFFSVHDPDYAKILLKRQD
(gap)
EKVIQDRKESLKDKLKQDTTQKRCR DFLDILLSAKSENTKDFSEADLQAEVKTFMFAGHDTTSSAISWILYCLAKYPGHQKRCRD EIRELLGDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGI TVFINIWALHHNPDFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLRNCIGQHFAIIEC KVAVALTLLRFELAPDHSRPPQPVRQVVLKSKNGIHVFAKKVC
CYP4Z2P human
NT_004386.11|Hs1_4543 92% to 4Z1 add full length version
652145 TKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDG 651978
CYP4Z2P human
AL731892.5 94% to 4Z1 1 stop codon in exon 8
67693 MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYQRRRWTIRAMHLFPAPPAHWFYGHKES 67514
66240 YPVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQ 66103
54555 DPKSAVSHKILESWV 54511
52843 GRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMML 52715
50555 NKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLD 50433
50353 STLDYLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 50198
40609 EKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKV 40502
35393 ENTKDFSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSSITW 35205
27034 EHLSQMPYATMCIKECLRLYAPVVNISQLLDKPITFPDGRSLPA 26903
12988 GITVFINIWALHHNPYFWENPQ 12923
11873 VFNPLRFSRESSEKMHPYAFIPFSAG 11796
10762 PRNCIGQHFAIIGCKVAVALTLLCFELAPDYSRPPQPVRQMLLKSKNGIHVFAKKV 10595
CYP4Z2P human
AK097373 mRNA 15-JUL-2002
breast, tumor tissue cDNA to mRNA
42 MEPSWLQELMAHPFLLLILLCMSLLLFQVIRLYRRRRWTIRAMHLFPAPPAHWFYGHKES 221
222 YPVKEFEVYPELMEKYPCAVPLWVGPFTMFFNIHDPDYVKILLKRQDPKSAVSHKILESW 401
402 VGRGLVTLDGSKWKKHRQIVKPGFNISILKIFITMMSKSVRMMLNKWEEHIAQNSRLELF 581
582 QHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHNDLVFKFS 761
762 SQGQIFSKFNQELHQFTEKVIQDRKESLKDKLKQDTTQKRRQDFLDILLSAKSENTKD 935
936 FSEADLQAEVKTFMFAGHDTTTTAISWIFYCLAKYPEHQQRC*DEIRELLGDGSSITWEH 1115
1116LSQMPYATMCIKECLRLYAPVVNISRLLDKPITFPDGRSLPAGL 1247
4AA Subfamily
Cyp4aa1 Drosophila melanogaster
AC004516, AC004304, AC005556, AC004426
This sequence was called CYP47 initially, but trees with the C-terminal
Sequence clearly place it in the 4 family. Since all the letters of the
alphabet have been used, I have had to start using double letters to
indicate the subfamily. This will permit naming 576 subfamilies with
double letters and 24 with single letters for a total of 600 subfamiles.
I don't think we will ever need that many.
35% to 4D2 35% to 4C1
Cyp4aa1 Drosophila melanogaster
GenEMBL AC020355 comp(15477-16779) and AC007579 comp(38212-38842)
MHLRLLSPPQLERTTNLELCSILILLVISLSIYTFYATLNTYLRSVLLSLRLTGPPSLPF
LGNCMLVTDKDLMRRCAGKAFDLYGSLVRIWVLLFPFFAVLEPEDLQVILSSKKHTNKVF
FYRLMHNFLGDGLITSSGSKWSNHRRLIQPAFHHNLLEKFIDTFVDASQSLYENLDAEAV
GTEINIAKYVNNCVLDILNEAVLGVPIKKRGQDVAMMEDSPFRQGKIMMPARFTQPWLLL
DGIYHWTKMANDELNQKKRLNDFTRKMIQRRRQIQNNNNGNSERKCLLDHMIEISESNRD
FTEEDIVNEACTFMLAGQDSVGAAVAFTLFLLTQNPECQDRCVLELATIFEDSNRAPTMT
DLHEMRYMEMCIKEALRLYPSVPLIARKLGEEVRLAKHTLPAGSNVFICPYATHRLAHIY
PDPEKFQPERFSPENSENRHPYAFLPFSAGPRYCIGNRFAIMEIKTIVSRLLRSYQLLPV
TGKTTIAATFRITLRASGGLWVRLKERDHPLIAH
Cyp4aa1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4AA1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPi2r2
CYP4AA1-de7b8b Anopheles gambiae (malaria mosquito)
CYP4AA1 Lutzomyia longipalpis Jacobina (phlebotomine sandfly)
GenEMBL AM096652 AM096653 AM096654 AM096655
63% to anoph. 4AA1, 62% to Drosophila 4AA1
4 FLKLLHNFLGNGLITSSGDKWNVHRKLIQPSFHLNILEKFIGTFNDSSQCLLDKFKSVEG 183
184 EVNITDFVNNCVLDILNEAVLGVPVFREDKEKEKSPFRQGKVVMPYRVTRPWLLLNWVY 360
361 KLTDTAASELNQKKQLDNFTRKMIHIRREAKRTGNLGERKCLLDYLIDISDQVPDFTEDD 540
541 IINEACTFMLAGQDSVGAAVAFSFFMLAQNPDCQKKCIEEIDNIFDGDTRAPTMRDLRE 717
718 MRYLEQCIKETLRLYPSVPLLARRLGEDIRVGEHTLIAGSHIFIVPYAIHRLPYIYPDPE 897
KFDPDRFLPEEVEKRNPYAFLPFSAGPRNCIGHKFAILEMKTVISKILR 379
378 HFTLHPVEGKEDLHPSFRVTLRATVGLWIKLQRRDKV 268
CYP4AA1 Apis mellifera (honeybee)
48% to Drosophila Cyp4aa1 (ortholog)
MGKVSSSLTSIYILYILRTYIRSIIYISQLNGPKTIPIIGNANSILKEN (1)
FLYRLAYESQMYGRIVRIWLTIFPYVMFLEPEDIQLILNNAKHTQKVFFYKLLDNFLGKGL
ITRDIKSWRIHRRLLQPAFHLHVLEKFTNTFAKHADHLMNKILEKNNQEINITTFINDSVYNILS (1)
ETVLGINRINRINEMDDLPFRK (2)
GQIMLLYRMIRPWLLIEWIYRLTKYGREEEKQRKNLFDTCFKMVKEKRDLLQSKDRISNNDIKKNK
NISLLEYMVEINEKNPCFSDEDIVEECCTFMLAGQDSVGTATAMTIFLLANHPEWQNKCIEEIDEI
FNGDTRFPTISDLKEMKCLEMCIKESLRLYPSVPIIGRTLGEDIKI (1)
GKHIIPAGCSVLISPYSTHHLPHHFPDPDTFKPERFNSENSEKRHPYAYIPFSAGPRNCI (1)
GYKFAMLEMKSIISAILRKCRLQSIPGKKEIRPKFRMTIRAQGGLWVKIIERDQILKSIAA*
CYP4AA1 Linepithema humile (argentine ant)
No accession number
CYP4AA1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
79% to CYP4AA1 Linepithema humile
CYP4AA1 Tribolium castaneum (red flour beetle)
GenEMBL XP_973810 AAJJ01000447.1
44% to CYP4aa1 Drosophila, 37% to CYP4BN8
41% to 4aa1 bee, 43% to 4aa1 Anopheles
MWTDICTYLVILAVMLMSIYFKNYIRSVYLAFQLSGPPAVPLIGNVL
LMKNDRSKYQFFRGHILS (1?)
EMYSPFMRCWLSIFPVFFIYEPKALQLIMGTNRYTSKNIFYNCLHNVVGDGLITSS (1)
GEIWKQHRKLIQPYFHISVLKVYFDIFYKWS
41760 MAMVQDLENETEVNITKYANKFVFD (0)
SQYWAFLGKDQSRLLIGGNLVQHIHQ (1)
CQFLMLHRITRPWLLFNTIFKRTDFSKVEENQKNILQQYTKS (0)
41348 ILDGKKQNSHGTAMNNLMEMMMEISNMNPEFTDDDIVNETCTFMLA (0)
41162 GQDSVGAALSFALYSLAAHQDIQEKVVQELNGIFKDGNQAATFEDVAEMKYLEQCIKETLRLYPSVPM
ITRKITEDVPL 40926 (1)
GKYTLPTGTNIVISPFVTHRLPHVFPDPLKFDPDRFS
PENKAKIHPYGFIPFSAGPRNCI (1)
GYKFAIIELKTVLSQILRKYHVSLVPGREKLILSYRMTLKAKKGIWLRLKKRSV*
CYP4AA1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
40% to CYP4AA1 D. pseudoobscura
39% to CYP4AA1 Anopheles gambiae
38% to CYP4AA1 Tribolium
CYP4AA1 Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
50% to 4AA1 Apis, 45% to 4aa1 Drosophila probable ortholog
CYP4AA1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AA1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-1 and P-4-9
65% to CYP4AA1 Tribolium castaneum (aa 260-317 with intron)
This piece and P-4-1 are missing about 9 amino acids between them.
63% to CYP4AA1 Tribolium castaneum (aa 327-482), C-terminal
CYP4AB1 Solenopsis invicta (fire ant)
GenEMBL AY345970
Nannan Liu
submitted to nomenclature committee 8/16/99
51% to 4Q2 and 4M4
MPRQHLINLLFSLCDKYYPIFRTWAFFEGFVSIRHPDDLEVILN
SSTNIEKSRIYSVLHPWFGLGLLTSGGSKWHSRRKILTPTFHFNILQQFVEILIEEGE
SMTNSLKNAGSTITKDLVPLISEHTLNAICETAMGTSLQGMNSVQQEYRKAVHRMGEL
FIYRLVRHWLISDWIFALTSQGREQVKILKILHGFTNKIIAERKDYHKRTNGQYLKNF
NQSIITDNEEIVGSKKKRLAMLDFLIYASQEGHLTDVDIREEVDTFMFEGHDTTSTSL
CYTLALLAENKDIQDRVRQEVDLVMQENEGKLTIKSLQNLQYLERCIKESLRLYPSVY
FISRITTEEAQLKSHLIPVGTIMHLHIYGVHRDPNFWPNPDVFDPDRFLPENSRNRHP
YSYIPFSAGPRNCIGQRFAMLEMKAMIAPLIHNFCLEPVDLLKNLRVGPDLVLRPLGG
HRIKFIPIATKCI
CYP4AB2 Solenopsis invicta (red imported fireant)
GenEMBL AY345971
Nannan Liu
submitted to nomenclature committee 9/24/02
43% to 4C1 and 43% to 4M7 71% to CYP4AB1
Note: formerly named CYP4AS1 by mistake
MFIALLLIIIVVYLMCHCYAQYGPNGRLINKIPGPPGYPIIGNL
FNLLESREQFWETLSILNEQYYPIYKLRAFFNSLVFIRHPDDLEIILNNTKHISKSNL
YDALRPWLGMGLLTSGGSKWHLRRKILTPTFHFNILQQFVEILIEEGESMTRSLKNAG
GTITKDLVPFISEYTLNAICETAMGTSLQEMGSFQQQYRKAVHRMGELLVYRAMRPWL
KYDWIFSLTSKGREQKKLLKILHGFTEKVIAKRKDYHKRTKGQYLKNLNKDVVPNETE
TIGIKKKRFAMLDLLIQASQEGLLTDFDIREEVDTFMFEGFDTTGMAMCFILSLLAEH
KDIQDCVRKEIDAVMQENQGKLNMKSLQDLQYLERCIKEALRLYPSVYFISRITSEET
ELKTYLIPAGTLVILNFYITHRDSNFWPNPEVFDPDRFLPDNIRNRHPYSYLPFSAGP
RNCIGQRFALLELKAMLVPLIYNFYLEPVDYLENQRFGIDMILRSLDPCRLKFVPIAT
EGI
CYP4AB3 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5748 (1270-4633)
50% to CYP4AB2 fire ant
formerly CYP4AZ1
renamed to recognize a large hymenopteran clade
N-term extended to match other CYP4AB seqs.
MISAILFFIFLLATLHYFLLHHRKFGKMINLIPGPEPLPILGNIPTFHNISP (1)
SELWKFLTQLSKQYYPIYRMWTFLEAYVHICHPDDIE (0)
TILGNIKFTKKGFGYKYLKPWFNTGLLTSS (1)
GHKWHVRRKILTSAFHFNVLRQFVDIFIEDAERLIKTLESEEGIFVENLLQLTSEHTLNVIC (1)
ETAMGTSLKNKEKFQYEYRKAVYNMGCIFANR(2)
IVKPWFYYDFFFNLSPEGWQQSKLLKILHNFTRK(0)
IIQERKEYHDKTNGRYLNDFHENINENDNNNDYND(1)
FRRKRLAMLDLLIEAHRNNKIDDEGIREEVDTFMFR(0)
GHDTTAISFCFSIMLLAEHKEIQ(0)
DRARAEIKAAIEENGGKLNITVLQNLPYLERCIKESLRLFPSVPRISRKLETSVKL (1)
SNYEIPSNTIINVNIFDTHRDPKFWPNPNKFDPDRFLPENSKKRHPYAYVPFSAGPRNCI (1)
GQRFAMLELKTYLGLLLYNYYFEPIDYLKDVTFVSGIVLRLENPVRMKFIPVKKIC*
CYP4AB4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB6 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB7 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB8 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB9 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB10 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB11 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB11-de7b8b10b11b Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB12 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB13 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB14 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB15 Nasonia vitripennis (jewel wasp)
GE363597 EST
See wasp page
CYP4AB16 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB16-de1b2b Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB16-de1c2c11c12c Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB17P Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB18 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB19 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB20 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB21 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB22 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB23 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AB24 Solenopsis invicta (Lausanne fire ant)
EE131689 EST
N-term region of CYP4AB
65% to CYP4AB2
YPIIGNTIKLINLGVLRIWKYIICTSSDKYYPIWKLRSFFESLVIIRHPDDMETILN
NTKHINKSKLYDILHPWLGTGLLTSTDSKWHTRRKILTPTFHFNI
CYP4AB25 Solenopsis invicta (Lausanne fire ant)
EE142405 EST
46% to CYP4AB2
MFVTLLILCVSIILLYFITYYGRFRRLIGKVPSKPDLPFIGNALEFFMYS
QEKIWEAERLANKTHTIYTFWCGPIAFIATRDPDDIEKILSNTTQHLSKGYIYNLLHPWL
GTGLLTSEGAKWRKRRKILTPTFHFTILKEFVDIFTEESNRMIKYLKNIEGSNIDNLMNF
ISHHTLNAICG
CYP4AB26 Solenopsis invicta (Lausanne fire ant)
EE148664.1 EE147029.1
MAY JOIN WITH 4AB24 82% TO 4AB2, 72% TO 4AB1
TLNAICETAMGI
SLQGLGSFQQQYRKAVHQMGEFIVYRLLRQWLKNDWIFSLTPRGREQAKL
LKILHGFTEKIIKERKDYHKLTNGQYLKNLNKDAVADEEIIGIRRKRLAMLDLLIQASQE
GLLTDKDIREEVDTFTFEGHDTTSSGICFTLALLAEHKDIQERVRKEIDVIMKENQEKLT
MKSLQDLQYLERCIKEALRLYPGVFFISRNTSEKVQLKSYLIPAGTLLHLNIFGVHRDPK
FWPNPEVFDPDRFLPDNIRNRHPYSYLPFSAGPRNCIGQRFALLELKAMLVPLIYNFYL
EPVDYLENQRFGIDMILRSLDPCRLKFAPIATEGI*
CYP4AB27 Solenopsis invicta (Lausanne fire ant)
EE134101 EST
70% to CYP4AB2
DGDHSTGSKWQSRRRLLTPIFHFNALQQFTEILIEEGESMANSLKNAADTITKDLV
PFISEHTLNAICEAVVGISPQKMGSFQHQYWTAVYRINEFIIYR
CYP4AB28 Linepithema humile (argentine ant)
No accession number
CYP4AB29 Linepithema humile (argentine ant)
No accession number
CYP4AB30 Linepithema humile (argentine ant)
No accession number
CYP4AB31 Linepithema humile (argentine ant)
No accession number
CYP4AB32 Linepithema humile (argentine ant)
No accession number
CYP4AB33 Linepithema humile (argentine ant)
No accession number
CYP4AB34Pv1 Linepithema humile (argentine ant)
No accession number
CYP4AB34Pv2 Linepithema humile (argentine ant)
No accession number
CYP4AB35P Linepithema humile (argentine ant)
No accession number
CYP4AB36 Linepithema humile (argentine ant)
No accession number
CYP4AB37P Linepithema humile (argentine ant)
No accession number
CYP4AB38 Linepithema humile (argentine ant)
No accession number
CYP4AB39P Linepithema humile (argentine ant)
No accession number
CYP4AB40 Linepithema humile (argentine ant)
No accession number
CYP4AB41P Linepithema humile (argentine ant)
No accession number
CYP4AB42 Linepithema humile (argentine ant)
No accession number
CYP4AB43P Linepithema humile (argentine ant)
No accession number
CYP4AB44 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
61% to CYP4AB2 Solenopsis invicta
CYP4AB45 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
55% to CYP4AB1 Solenopsis invicta
CYP4AB46 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
61% to CYP4AB1 Solenopsis invicta
CYP4AB47 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
CYP4AB48 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
56% to CYP4AB1 Solenopsis invicta
CYP4AB49 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
CYP4AB50 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
61% to CYP4AB1 Solenopsis invicta
CYP4AB51 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
46% to CYP4AB25 Solenopsis invicta (N-term only)
CYP4AB52 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
58% to CYP4AB1 Solenopsis invicta
CYP4AB53 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
65% to CYP4AB30 Linepithema humile
CYP4AB54P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
63% to CYP4AB32 Linepithema humile
CYP4AB55P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
71% to CYP4AB1 Solenopsis invicta
CYP4AB56 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
56% to CYP4AB1 Solenopsis invicta
CYP4AB57 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
CYP4AB58P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
53% to CYP4AB36 Linepithema humile
CYP4AB59P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
34% to CYP340F1 Bombyx mori (may be a false positive)
upstream from CYP4AB60
CYP4AB60 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
CYP4AB61 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
CYP4AB61-ie4b Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
53% to CYP4AB27 Solenopsis invicta
CYP4AB62P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
60% to CYP4AB26 Solenopsis invicta
CYP4AB63P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
CYP4AB64P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
56% to CYP4AB1 Solenopsis invicta
CYP4AB65P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
42% to CYP4AB32 Linepithema humile
CYP4AB66P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
51% to CYP4AB2 Solenopsis invicta
CYP4AB67P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
50% to CYP4AB2 Solenopsis invicta
CYP4AB67-ie6b Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
68% to CYP4AB26 Solenopsis invicta
CYP4AB68 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
62% to CYP4AB1 Solenopsis invicta
CYP4AB69 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
60% to CYP4AB1 Solenopsis invicta
CYP4AB70 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP4AB1 Solenopsis invicta
Cyp4ac1 Drosophila melanogaster
GenEMBL AC017771 comp(24745-26507)
Cyp4ac1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4ac2 Drosophila melanogaster
GenEMBL AC017771 comp(22220-24109)
Cyp4ac2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp4ac3 Drosophila melanogaster
GenEMBL AC017771 comp(20241-21996)
CYP4AC4 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
54% to Cyp4ac1 Drosophila melanogaster
Cyp4ad1 Drosophila melanogaster
AC020402 comp(36565-39829)
Cyp4ad1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4AD1 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
67% to CYP4AD1 D. pseudoobscura
clone name 1196
Cyp4ae1 Drosophila melanogaster
GenEMBL AL009194 16210-17867
Old Cyp4e4 renamed
Cyp4ae1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP4AE2 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP4AE
59% to 4AE1 (148 aa)
Cyp4af1x discontinued name see Cyp4ad1
CYP4AG1X discontinued number assigned to sea bass 4F7 seq due to
An error at the C-terminal of this sequence (see 4F7 above)
CYP4AH1X discontinued name see CYP4V2 human
CYP4AJ1 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF243506
Scharf,M.E., Srinivas,P., Siegfried,B.D. and Meinke,L.J.
Insecticide Resistance Associated Cytochrome P450 Gene Fragments
from D. v. virgifera
Unpublished
DvP450-1
CYP4AK1 Diabrotica virgifera (western corn rootworm) a beetle, Order Coleoptera
GenEMBL AF257100
Isolation of family 4 cytochrome P450 gene fragments from
insecticide-resistant and -susceptible western corn rootworms
Unpublished
DvP450-3
CYP4AL1 Mytilus edulis planulatus (Australasian version of common mussel)
No accession number
Karl Herron
46% to 4T4 from Xenopus, 38% to 4Y1 from blue mussel,
39% to abalone 4C17
submitted to nomenclature committee Jan. 30, 2001
I-helix to heme region
CYP4AM1 Plebidonax deltoides (Pipi or Goolwa cockle, a type of clam)
No accession number
Karl Herron
48% to 4T4 Xenopus 48% to 4A20
partial seq. from I-helix to heme
submitted to nomenclature committee Oct. 9, 2001
CYP4AN1 Daphnia pulex (Daphnia, water flea)
BQ703378 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.3 205 aa
53% to 4B1 52% to 4V2 54% to 4v3 53% to 4W1 93% to 4AN2
CYP4AN2 Daphnia pulex (Daphnia, water flea)
BQ703379 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.3 prime 209 aa
57% to 4C17 55% to 4C18 93% to 4AN1
CYP4AN3X Daphnia pulex (Daphnia, water flea)
BQ703375 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.1 149 aa
58% to 4v3 mouse 59% to 4c24 66% to 4AN2
renamed CYP4BY5v2 based on genomic full seq
CYP4AN4 Daphnia pulex (Daphnia, water flea)
CYP4AN5 Daphnia pulex (Daphnia, water flea)
CYP4AN6 Daphnia pulex (Daphnia, water flea)
CYP4AN7 Daphnia pulex (Daphnia, water flea)
CYP4AN8 Daphnia pulex (Daphnia, water flea)
CYP4AN9 Daphnia pulex (Daphnia, water flea)
CYP4AN10 Daphnia pulex (Daphnia, water flea)
CYP4AN11 Daphnia pulex (Daphnia, water flea)
CYP4AP1 Daphnia pulex (Daphnia, water flea)
BQ703376 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.2 197 aa
49% to 4V2 50% to 37A1 51% to 4C21 74% to 4AP2
CYP4AP2 Daphnia pulex (Daphnia, water flea)
BQ703377 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.2 prime 187 aa
49% to 4V2 47% to 4C1 51% to 4C21 74% to 4AP1
CYP4AP3 Daphnia pulex (Daphnia, water flea)
CYP4AP4 Daphnia pulex (Daphnia, water flea)
CYP4AP5 Daphnia pulex (Daphnia, water flea)
CYP4AP6 Daphnia pulex (Daphnia, water flea)
CYP4AP7 Daphnia pulex (Daphnia, water flea)
CYP4AP8 Daphnia pulex (Daphnia, water flea)
CYP4AQ1X Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
57% to 4H9 fragment (from Anopheles albimanus)
but 44% to 4H24 so new 4 subfamily related to 4H
same seq as CYP4H26 above
CYP4AR1 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
41% to 4D2 lower to other 4Ds
CYP4AR1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPe2r2
Note very similar to CYP4K2 (almost in the same subfamily)
CYP4AR2 Aedes aegypti (yellow fever mosquito)
CYP4AR3 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 11
70% to CYP4AR2 Aedes, 45% to 4AR1 Anoph.
CYP4AR3 Culex pipiens
CYP4AR4 Culex pipiens
CYP4AS1X Solenopsis invicta (red imported fireant) renamed CYP4AB2
No accession number
Nannan Liu
submitted to nomenclature committee 9/24/02
43% to 4C1 and 43% to 4M7 71% to CYP4AB1
CYP4AT1 Capitella capitata (polychaete worm)
No accession number
Bo Li
submitted to nomenclature committee 2/3/2004
Most similar to CYP4T and CYP4F
CYP4AU1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #14 HaCypZ014a-v3Pep revised from earlier seq.
51% to 4M4 235aa fragment from C-term
CYP4AU1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000052 4 aa diffs to CYP4AU1 of Grubor in the C-term part
53% TO CYP4AU2, 38% to CYP341A3, 36% to CYP4G25
CYP4AU2 Bombyx mori (silkworm)
No accession number
See silkworm page for details
CYP4AU3 Heliconius erato (red postman or red passion flower butterfly)
GenEMBL EST EL596754.1
N-term 51% to CYP4AU2
MFVAVLICLFCCLYYLHFRRKRKQLYEFSKSI
PSVGNLPVVGHSHWFIGGPEKILKNIQTLAQMIEDSGGISSIWLGPTLYVVTMNPEDVQK
ILENSLQKDFSYKFLQEWLGNGLFVAPVDLWKVHRRLLLPVFHNRIIEDYIDVFGEQGSV
LVKRMGEKVGKSEFDVFPYITSCMLDIVFETAMGEKMDVQHNPDTPYLRARNTVISI
CYP4AU3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP4AU1 Helicoverpa armigera
CYP4AU4 Heliothis virescens
GR960305
LSHKEGRKDILQLLLERKLAFSNIELREHIDSITIAGNDTTTLVISYALVLLGDHQDAQD
KVYKELQEIFGDSKRTPTKEDLTKMEYLERVIKETMRLYAVVPIIARTTQKELKLSTCTI
PAGVGCVVVPMVLHRSKKLWGPDADCFDPDRFLPENSVDRHPCAYIPFSHGTRNCIGRHF
GMLAMKSILATFLRTYKVSSKIPDRLKIEILLFPVDGHQITIEKRL*
CYP4AU5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP4AU2 Bombyx mori
CYP4AU6 Plutella xylostella
Gene number CCG0015762.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
69% to CYP4AU1 Helicoverpa armigera
missing the correct C-term
CYP4AV1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2000
41% to CYP4C3 Drosophila.
CYP4AV2 Apocrypta bakeri (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 25, 2007
65% to CYP4AV1 Apis, 82% to CYP4AV3, 81% to CYP4AV4
CYP4AV3 Philotrypesis sp (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 25, 2007
Philotrypesis sp4
68% to CYP4AV1 Apis, 97% to CYP4AV4, 82% to CYP4AV2
CYP4AV4 Philotrypesis sp (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 25, 2007
Philotrypesis sp5
66% to CYP4AV1 Apis, 97% to CYP4AV3, 81% to CYP4AV2
CYP4AV5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4AV6 Trialeurodes vaporariorum (whitefly)
confidential
CYP4AV7 Linepithema humile (argentine ant)
No accession number
CYP4AV8 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
80% to CYP4AV7 Linepithema humile
CYP4AW1 Phyllopertha diversa (scarab beetle)
GenEMBL AY605086.1
Maibeche-Coisne,M., Nikonov,A.A., Ishida,Y., Jacquin-Joly,E. and
Leal,W.S.
Pheromone anosmia in a scarab beetle induced by in vivo inhibition
of a pheromone-degrading enzyme
Proc. Natl. Acad. Sci. U.S.A. 101 (31), 11459-11464 (2004)
Submitted to nomenclature committee Nov. 4, 2003
Clone name Cyp4Pd1
41% to CYP4C1 40% to CYP4D2
61% to CYP4W2
CYP4AW2 Phyllopertha diversa (scarab beetle)
GenEMBL AY605087.1
Maibeche-Coisne,M., Nikonov,A.A., Ishida,Y., Jacquin-Joly,E. and
Leal,W.S.
Pheromone anosmia in a scarab beetle induced by in vivo inhibition
of a pheromone-degrading enzyme
Proc. Natl. Acad. Sci. U.S.A. 101 (31), 11459-11464 (2004)
Submitted to nomenclature committee Nov. 4, 2003
Clone name Cyp4Pd2
42% to CYP4C1 42% to CYP4D2
61% to CYP4W2
CYP4AX1 Bombyx mori (silkworm)
BAAB01092965.1 BAAB01135526.1 BAAB01183645.1
50% to CYP4S4
See silkworm page for sequence
CYP4AX2 Bombyx mori (silkworm)
BAAB01152933.1 BAAB01194854.1 BAAB01058563.1
BAAB01102208.1 BAAB01008375.1
94% to CYP4AX1
See silkworm page for sequence
CYP4AY1 Ips paraconfusus (a bark beetle, California fivespined ips)
No accession number
Dezene Huber
Submitted to nomenclature committee Nov. 10, 2004
38% to CYP4AW1 from scarab beetle p= e-88
40% to CYP4S3 p= e-77, better percent match but poorer p value.
CYP4AY2 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
56% to 4AY1, full length
CYP4AZ1X Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5748 (1270-4633)
50% to CYP4AB2 fire ant
renamed CYP4AB3 to recognize a large hymenopteran clade
CYP4BA1X Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_49183273 (824-692) partial seq.
52% to CYP4AA1
name changed to CYP4AA1 (ortholog)
CYP4BB1 Nereis virens (annelid polychaete worm, clamworm, sandworm)
GenEMBL AY453407.1 (partial seq)
Rewitz KF, Kjellerup C, Jorgensen A, Petersen C, Andersen O.
Identification of two Nereis virens (Annelida: Polychaeta)
cytochromes P450 and induction by xenobiotics.
Comp Biochem Physiol C Toxicol Pharmacol. 138, 89-96 2004.
Clone name CYP4(1), CYP41 in abstract
Submitted to nomenclature committee April 29, 2005 (full seq)
41% to 4f15 mouse, most similar to vertebrate 4F seqs.
CYP4BB2 Perinereis nuntia (polychaete worm)
No accession number
Senlin Zheng
Submitted to nomenclature committee Feb. 22, 2011
68% to CYP4BB1
CYP4BB3 Perinereis nuntia (polychaete worm)
No accession number
Senlin Zheng
Submitted to nomenclature committee Feb. 22, 2011
69% to CYP4BB1
CYP4BB4 Perinereis aibuhitensis (polychaete worm)
HM126463
88% to CYP4BB3
CYP4BC1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CD449348, CF075894.1, CO741868.1
David Drane
4clan 52% to 4C3(bottom half only)
N-term and C-term
These ESTs are missing the middle region between
The C-HELIX and the I-helix.
The ESTs are continuous across the gap region
Like several exons have been skipped.
MFFLNVVIYFLIGFLVTRLVKIFLKYRRIASHIDK
IAGPPRLWLPVGNALQLSGNHFKFFQQIRQLAKDYREQSPTGALRLWIGPYPYVIMVKGK
AAEAVLSSYKFLEKGPDYDLVHPWLGTGLLTSTGDKWRSRRKFLTPAFLDLL
LSAKTEDGKVLDNASIREEVDTFMFEGHDTTSVAAAFAVFLLGNHQDVQQKAYEELRQIF
GDSDRAPTTEDLKNMRYLDCVLKESLRLYPSVPMITRKCNEDYKLPDSDIIIPEGSIVSI
FIFALGRDPDMFPEPDRFDPERFSDTKSARHRPFDYVPFSAGPRNCIGQKFAVMEEKTIL
STILRSYTIQSVEDPETLRIAGELITRPIDGISVKLFR
CYP4BD1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
43% to 4AW1, full length
CYP4BD2 Ips pini (pine engraver, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
79% to 4BD1 Ips paraconfusus, 54% to CYP4BN4
clone name EST 25A04
CYP4BD3 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Formerly CYP4BP1
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
46% to CYP4BM1 Tribolium castaneum
clone name EST MPB4B04
note 79% to CYP4BD1 so the name was changed to CYP4BD3
CYP4BD4v1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
58% to CYP4BD2 Ips pini (pine engraver, bark beetle)
clone name DPO1124_K13
CYP4BD4v2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
58% to CYP4BD2 Ips pini (pine engraver, bark beetle)
insertion relative to other P450s
clone name DPO1414_C01
CYP4BD5v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH2-1
80% to CYP4BD4v1 Dendroctonus ponderosae,
100% to clone CYP4BD5v2 at the amino acid sequence level
CYP4BD5v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH2-2
80% to CYP4BD4v1 Dendroctonus ponderosae,
100% to clone CYP4BD5v1 at the amino acid sequence level
CYP4BD5v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4A-1
1 aa diff to CYP4BD5v4
97% to CYP4BD5v1
CYP4BD5v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4A-2
1 aa diff to CYP4BD5v3
97% to CYP4BD5v1
CYP4BD6 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
78% to CYP4BD4v1 Dendroctonus ponderosae
CYP4BE1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
45% to 4V2, 44% to 4C1 55% to 4C18 lobster
missing about 88 aa at N-term
CYP4BE2 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
65% to 4BE1
CYP4BF1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
50% to 4BE1, full length sequence
53% to 4AN3 Daphnia from I-helix to heme
CYP4BF2 Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee Aug. 15, 2007
59% to 4BF1 Ips paraconfusus
I-helix to heme region
CYP4BF2 Ceratosolen solmsi martchali (Hymenoptera) fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
Only two amino acid differences to Philotrypesis pilosa CYP4BF2
In the overlapping region
This is a clear ortholog so it has the same name
I-helix to heme region, with some missing sequence
CYP4BG1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
43% to 4J9 full length sequence
52% to 4C21 from I-helix to heme
CYP4BG2v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH3-1
60% to CYP4BG1 Ips paraconfusus
98% to CYP4BG2v2
CYP4BG2v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH3-2
60% to CYP4BG1 Ips paraconfusus
98% to CYP4BG2v1
CYP4BG2v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4B-1
97% to CYP4BG2v2
98% to CYP4BG2v4
CYP4BG2v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4B-2
99% to CYP4BG2v2
CYP4BG3 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
94% to CYP4BG2v4 Dendroctonus valens
CYP4BH1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
43% to 4AW1 full length sequence
CYP4BJ1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
41% to 4BF1, missing sequence after heme signature
CYP4BJ2 Ceratosolen solmsi martchali (Hymenoptera) fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee July 17, 2007
57% to CYP4BJ1
This seq will be less than 55% identical to 4BJ1 in full length,
so the name may not be correct. However, the next closest match
is 46% so this looks like it may be an ortholog.
CYP4BJ2 Philotrypesis pilosa (Hymenoptera) non-pollinating fig wasp,
No accession number
Dong-Guang Wan
Submitted to nomenclature committee Aug. 15, 2007
57% to 4BJ1 Ips paraconfusus
Only 3 amino acid differences to Ceratosolen solmsi martchali CYP4BJ2
This is a clear ortholog so it has the same name
I-helix to heme region
CYP4BK1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 60_1_ext
41% to 4F11, 43% to 4F6
57% to part of CYP342A1 Nereis AY453408, but not to whole seq
same region is 57% to CYP4F11
CYP4BK1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-2a
CYP4BK2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-2b
CYP4BK3 Ruditapes philippinarum (Japanese littleneck clam, mollusc)
GenPept FJ516740.2
55% to CYP4BK1
CYP4BK4 Meretrix meretrix (hard clam, mollusc)
No accession number
Hongjun Li
Submitted to nomenclature committee April 30, 2012
86% to CYP4BK3 Ruditapes philippinarum (Japanese littleneck clam)
55% to CYP4BK1
CYP4BK5 Capitella teleta (polychaeate worm, annelid)
CYP4BK6 Perinereis nuntia (polychaete worm)
No accession number
Eun-Ji Won
Submitted to nomenclature committee Feb. 16, 2012
54% to CYP4BK3, 50% to CYP4BK1
60% to CYP4BK5 Capitella teleta
formerly CYP4DU1
CYP4BL1v1X Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 54_4_F_ext
52% to part of seq CYP4FA1 AF163824.1 Coscinasterias muricata
47% to CYP4Y1 Mytilus galloprovincialis (blue mussel) AF072855 partial
seq
Note: these old sequences have been replaced by newer versions below
CYP4BL1v2X Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Mark Hahn, Kristen Whalen
Submitted to nomenclature committee Oct. 24, 2005
Clone name 54_9_F_ext
97% to CYP4BL1v1X probable allele
Note: these old sequences have been replaced by newer versions below
CYP4BL1v1 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3a1v1
CYP4BL1v2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3a1v2 (old CYP4BL1v1X above)
CYP4BL1v3 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3a2
CYP4BL2 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3c possible hybrid of CYP4BL1 (N-term)
and 4BL3 (C-term) genes.
CYP4BL3 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b3
CYP4BL4 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b1
CYP4BL5 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #1
CYP4BL6 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #2
CYP4BL7 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #3
CYP4BL8 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #4
CYP4BL9 Cyphoma gibbosum (cowrie, gastropod mollusc)
No accession number
Kristen Whalen
Submitted to nomenclature committee Feb. 4, 2008
Clone name CYP4-3b2 #5
possible hybrid of CYP4BL3 or CYP4BL8 (N-term) with CYP4BL1 (C-term)
CYP4BM1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966563
poor match 42% to 4C3
MDFTYLLLFTFFTIGFVNFCKWLKDRKRIWDAIEPIGGEKWYPLIGTCLELIKTKRKDFYDVYCARNMKY
GPFFRTWMGFIPAVHVMKPDHVERILSSTVNLTKGDNYRFVVPWLGEGLITGSNHKKWRVHRKLITPTFH
FSILDNMMEVMAEKGQFLAEQLVPKANGQFFNIYPFLTLCELDIICETAMGVEVNAMKHSQSEYVRSVYG
ISDIMLYRMFHPYLHPDFVFNLSSKGRQHKKYLSILHGFTRKVIQERKEKLTSGRDVVQELSEEDKLLGK
KKRLAFLDLLLEANKNSEGGLTDEDIREEVDTFMFAGHDTSTVTVGWTLFTLSNYPEYQEKVHQELDEIF
QGEERPITPQDVLKMQYLDKVIKETQRLIPVVPVIARTLDQDLEIVASSRTIPAGVMVVIHLARLHKDPD
QFPEPDRFDPERFLPENVSKRHPYSFVPFSAGPRNCLGQKFALRNTKVLLASILRKYKVRAEKKIDEMKY
NIEIVLRPQGGLSVALEPRRR
CYP4BN1 Tribolium castaneum (red flour beetle)
GenEMBL XP_971854
66% to 4BN4, 48% to 4AW1, 48% to 4BH1
MGALALVVFAVTTLLFLIWFIRLVRKNNDYYKDIPGPRPLFFFGNVFEVSTTRDILNVMHKYALQFNGLY
KIHLGPVRKLIIASDYKFLECVLSSMKILNKSEDYLYLRPWLGTGLLTSDGPKWKKHRKIITPAFHFQIL
EQFVEVFESGGNRFVQQLQKEVGKKSVDIYPYVTLCTLDIICESAMGISINAQFDDNSDYVRSVKAMCRI
TMERLFHLLEMNDVTYPLTKNYYTQKKSLNVLHNQTNSVINRRRKELENKTEAINVTNEDKADNNDTLFG
RNKKAFLDLLLQATVDGRPLTQEEIREEVDTFMFEGHDTTASAISFAIYCLANNADVQAKAYEEQIALFG
GNKSPAVTYSDLQSMKYLELVIKETLRLYPSVPMFARKTSEPVQYENIFIPEGVTVNIFAYGIHRDPKYF
KDPEKFDPSRFETVDGKLPYAYIPFSAGPRNCIGQKFAMLEMKSTISKVLRNFELQPATPTHTVQLAAES
VLKSANGVKIALKNRN
CYP4BN2 Tribolium castaneum (red flour beetle)
GenEMBL XP_971905
72% to 4BN5
MILPILLCLIFSFLIWSLYQTCKKNSFYKNIPGPSGVPIFGIAFEFKSTQ (1)
DVLINLTSYIKTYGDIVTAKIGPFR
86921 RYLLVSDYNFLECVLSSTKLIKKSHHYTFFQGWLGTGLLTAD (1)
GAKWKTHRRILTPAFHFQILEQ 86682
FIEVFEKCGDVLVKKFENEVGRKSFDIYPYVTLHTLDVICESIMGISVNAQNNSTSEYVNSVKNICKIFV
ERSVSPLQMCRFMYPFTKNYWAEQKALKILHQHTNSVIDARRKELHKAENGHNTNPKKSKKPFLDLLLET
KIDGIPLTQEEIREEVDTFMFEGHDTTASAISFTLYSLANNLHVQEKAVDEQKKIFGERKDVTAAYADLQ
NMKYLENIIKESLRLYPSVPFYNREITDDIMFDNKLLPKGDTIMVFAFAIHRNAKYFDNPEQFNPDRFND
LENKLPYAYIPFSAGPRNCIGQKFAMLEMKSTISKILRKYKLLPADPQHELNLVSELILKSSNGIKISIE
PRC
CYP4BN3 Tribolium castaneum (red flour beetle)
GenEMBL XP_966858, XP_975914
56% to 4BN1
MALLTDVFLPLVIILLIFWYWYRSQKNKKYYQNVATPPTVPILGNALDFTTTTELLGTFMRYRKDYGGLV
KVHIGPLRHFLLVSDYKMLEYLLSSPKIVDKSEDYKFLSSWLGTGLLLADGGPKWKKHRKILTPAFHFQI
LEQFVDVFDSCSNVLIQKLDKEVGNTSVDVYPFVTLFTLDVICESTMGTKINAQDDVTSDYVQSVKHMCR
IIIERSISPVQMYDFLFVFTRNYFIQRRALRILHDKADGVISQRLRELQAQTKTDSEGDSEGIKKKKAFL
DLILEAKVDGKPLSQDDIRQEVETFMFAGHDTTASAISFTLYCLANYPEVQKMAYEEQLSIFEDNNEPDV
TYANLQSMKYLELVIKETLRLYPSVPIIGRQSGEDFQF
DNSWIPKGDTMLLFLYGIHRDPKYFKDPEVFD
PNRFENPDNKMPYSYIPFSAGPRNCIGQKFAMLEMKCVLSKILRKFELQPAVPQHNLLLTAETVLKSANG
IKIGIKLRK
CYP4BN4 Tribolium castaneum (red flour beetle)
GenEMBL XP_971963
66% to 4BN1, 52% to 4AW1, 51% to 4BD1
MCCCFPLALAALHWPRDARVDDCRLCYPMPMRDAGQQLLQHQKLSGTLRMDTQAAAKTPTLALRHDAMQS
FNRPTFYLVLDIMMKYMKIYGGVVKFHGGPIDKTLLVSDYNFLENVLSSTKILNKTDDYKFLHSWLGTGL
LTSAGPKWKKHRRILTPAFHFKILEQFIDVFESAGNKLVKKLEKVVGKDSVDIYPFVTLCTLDIICETAM
GIKINAQDNGESEYVRSVKQMCKIIIERSFSLLQMINLTYPLTKNFYIEKNALKILHQQTNSVINQRRQE
LKNQSKNIEQENDLGTKTRKAFLDLILEATVDGRPLTDTEIREEVDTFMFEGHDTTASAISFALFCLATH
PEVQARALEEQKALFGDTKNPTPTYTDLQNMKYLEQVIKEALRLYPSVPFHGRKTNEAVEFNNGTVVPKD
VTITVFTYGIHRNPEYFKDPEKFDPSRFDTIDGKLPYSFIPFSAGPRNCIGQKFAMLELKSTLSKVVRKF
ELRPATPEHKLQLTAETVLKSVNGIKISLKLRQ
CYP4BN5 Tribolium castaneum (red flour beetle)
GenEMBL XP_967939
72% to 4BN2
MITIVIILIFILVSINFITKYLKKLKQNKDFYQNIRGPRGLPILGSALDFKTTK (1)
DVLQNLINYTRDYGEVVTAQIGPFHRYILVSNYDFLECVLSSTKLSSKSHNYNFLRPWLGTGLLTSD (1)
GAKWKTHRRILTPAFHFQILEQFIEVFEKCGNTLLEKLRNEVDKETCDIYPYVTMCTLDIICESIM
GISINAQEDSTSDYVQSVKNVCRIMVERSISPLQMCPFMYPLTKNYWTEKKSLKILHKQTNDVINARRKE
LESSKEVSSYEENFTKKKKPFLDLLLETKIDNRLLTQEEIREEVDTFMFEGHDTTASAVSFTLFCLANNL
ESQQKAFEEQQAIFGNIQNVTASYTDLQNMKYLEQVIKEALRLYPSVPFYGREITENVEYDGKLLPKGDI
LLIFAFGIHRNEKYFPNPEKFDPDRFHNMDNKTPYAYIPFSAGPRNCIGQKFAMLEMKSTVSKVLRQYKL
LPTTPQHELELVGETILKSTNGIKIRVTLRN
CYP4BN6 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000217.1, DT795816 = EST
76% to 4BN1, 46% to 4d2, 50% to 4D24,
51% to 4AW1, 43% to 4H8
MNIILEFFSALAVIIVLSWWYLFLKNYKVGKFFKNFSGPPGVPLLGNALDFKNKTK (1)
41530 GVLPAFLNYNKNFGGLVKVQIGPFRKLLLVSDYKFLEFVLSSTKIINKSQNYRTMLPWLGTGLLTS 41727
41728 EGIKWKKHRRIITPTFHFKILEQFINSFDAAGDVMINKLRKKVGIESVDIYPFVTLCALD 41907
41908 IIC (1) 41916
41969 ETAMGTTINAQNNEESEYVTSVKEMGRIIIERAIAPQKNNEFLFRFTKDY 42118
42119 QLQKSALKVLHNYTNNVISKRREELLKDQASKVSENVIDMGIKKKMAFLDLLLQATVDGR 42298
42299 PLTNEEIREEVDTFMFE (0)
GHDTTASGISFALYCLANNPEAQEKAYEEQVALFGKEKKPIVSYSDLQEMKYLELVIKEALRLYP
SVPFYARETNQEVEFGDI 42696
42697 KIPKGVNITIFAYGIHRDPKYFPEPDKFDPGRFETIDGKLPYAYIPFSAGPRNCI (1) 42861
42915 GQKFAMLEMKSTISKVLRNFKLCPATPHHTLDLVAETVLKSDNGVRLSLMERQ* 43076
CYP4BN7 Tribolium castaneum (red flour beetle)
GenEMBL XP_972577
66% to CYP4BN8
MYLIAIVIVLISLYLIVKPVKKTGNIDDFPEPPSKVFFGHALDAKSTTEILNVTTNYVKKYGKIVKLRLG
PFFKALVVTDYKLVEFFLSSNSLLTKSQNYAFARSWLGNGLILANGTHWKQHRKILTPAFHLEILREYLE
TFDSVGRIFIEKLKSLDNVQSVDLDALVPLCTLDVICETAMGTKINAQKGENSEYVSSVKEMCRIIVARF
LSPLKILKCTYWMTHDFYTERKVVNILHSFTSKVIDGRKTNRNETEKSGKKKAFLDLLLKFSDIEKLSDR
DIREEVDTFMFAGHDTTATGVCFALYLLANNPEVQEKVLSEQKELFGDEKNPCVTYQELQNMKYLEYVIK
ETLRLYPSVPVIGRYLKEDTTFGDRVISAKTNVAIFIYGIHRNPDYFPEPEKFIPERFENMTNLPPYAYI
PFSAGPRNCIGQKFAMLEMKSLISKVIRHFELTPANPHHELVLAAETVLKSANGIKIGLRARSENKM
CYP4BN8 Tribolium castaneum (red flour beetle)
GenEMBL XP_972624, AAJJ01005264.1
66% to CYP4BN7, 55% to 4BN4
MFIFAALFFLIIFYLYHQNVKLNRILCTFPEPPKKFLLGHVLDITSTT (1)
DVLNVFSK YINNYGPTIKLRAATLFAGLGTTDYKLCELLLSNNRILSKSLNYQYAR
NWLGNGLLISDGDYWRRHRKILTPAFHFEILKQFVETFESVGKVFVEKLDISQGPSVDLPPLVTLCTLDV
ICETAMGTQINAQKGQNAKYVQSVREMCRILIDRGLSPLKILNNTYWMTKDYYIEKKSLKVLHSFTSSVI
EKRKAERNERNCTKLAFLDLLLKFSNEGELLTDQELREEVDTFMFEGHDTTASSISFVLFCLANHPEVQE
KVLREQNELFGDDKDPSVTYHELQKMKYLEQVIKETLRLYPAVPIIGRCTSEDITFGEHFIPKDTNIAIY
IYGIHRNPEHFPEPETFNPDRFKNSNSLPPYAYIPFSAGPRNCIGQKFAMLEIKSIVSRVVRCFELRPAE
PYHSLVLSAETVLKSANGIKIGIRKRI
CYP4BN9 Tribolium castaneum (red flour beetle)
GenEMBL XP_971513, AAJJ01000614.1 also has 4BN10
66% to CYP4BN10
MIVFTGYLIAIVLILFPLYYYYAKCYALEKFYHQFPSPPKTPFFGNALDLKTTK (1)
DLFQSFHRYVKAYGT
17128 MVHLKIGPFDHMLLCSNPKFLEFLLTSNTLLKKSPNLRYLVPWIGTGVATAY (1) 16970
16925 GPKWKLHRKLVTPAFHYS
VLSQFVNTFESSGNILVEKISKLCDGQKVDNFDLYPHITRCTFDIICETAMGTKSNVQTNETSVYFESIK
EMCRIFMSRTMAVFQRYDFIFRFSKDFHLQKKALDIIHNYSNEVIATKRKELDENVKQKESVDDLGRKEK
MVFLDMILNKAIDGHIFSQEAIRGEVDTFMFAGHDTTATAISFILLCIANHNEVQDKIIEEQERLFGCEK
NPKVTFAHLQEMQFLENVIKEGLRLYTPVPLYGRQIDKNVEFEGMLIPKGVNVVIFNHGVHMNPEFYPNP
EKFDPNRFESMEDKHPFAFIPFSAGPRVCIGKKFAILEIKSILSKIVRNFELFPASPSYELDLAAETVLK
SLNGIRIGIKRRETF
CYP4BN10 Tribolium castaneum (red flour beetle)
GenEMBL XP_971570
66% to CYP4BN9
MSVLTEFFIALVALILLPFYFYYTKIRRIENFFKHFPSPAGVPILGVAPEFKTTSSVLDNFHKYAKAHGT
MVHLKFGPFKHALLCTDTKFLEFLLSSNKLLKKSVNLRFLEPWIGTGLVTADGGPKWKTHRKLITPAFHF
KILEQFVDIFESGGDILVKKLSEVSGSKSCDIYPYITKCTLDIICETAMGTKVDVQNTENSAYFESIKEM
CRIFTVRTVGAFLSNDFIFRFSKDYKIQTKAVKVLHNHSNEVIVNKRKELKEKNNENTSDIDELGRKKKK
VFLDLILSATTDGQSLSPEEIREEVDTFMFGGHDTTGTATSFILYCIANNKEAQEKILEEQKQLFGDERS
PKVTYSTLQEMKYLENAIKEGLRLYSPVPIYGRLIDQDTEYNGTMIPKGVGVIIFAHGIHMNPKYYPNPE
KFDPSRFENTTGKDPFTFIPFSAGPRNCIGQKYAMLEIKSLVSKVVRNFELFPASPTHEMHLAPETVLKS
LNGVKIGLKMR
CYP4BN11 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000275
53% to CYP4BN4, 49% to CYP4BN6
73454 MEILFTLFILLLCLLLYFYNKYVYIFDKNLKDYPAPPQVPILGHTLDF (0) 73597
73690 LIFLGFLDVLLSYTHKYGDIVRIRPGPIRQLLLTSNYKLFEAVLSNAKITKKSADYKFFHRWLGTG 73887
73888 LLTSDGAKWKKHRQIITPTFHFQILENFVDVFEKNGKILTKQLEKHLNEDSVNVYGFVNL 74067
74068 CALDIIC (1) 74088
74133 EAAMGTSVKAQENMNSEYVRSVKDLLDTLMGRIFSPYKMIDFIYFFTEDYKKEMKALQ 74306
74307 VIHSYTRNVIKSRQAAINSGEFEQKTKKNFLDLLLAANEQQMTLEEIREE 74456
74457 VDTFMFA (0) 74477
74527 GHDTTASTISFALFCLANHPDEQ (0) 74595
74648 ARVYREQKDIFGDDFKRAVTFQDLKKMKYLEYVIKETLRLYPVGPFFSRELDKDVPFAG 74824
74825 KVLPKGLTITLFIYAMHRNPEYFPDPEKFNPSRFETFDGKMPFAFVPFGAGPRNCL (1) 74996
75039 GQKFAMLEMLSVVSRVVRTYKILPSIPRHEINVAAQVVLISTNGMRMRFEKR 75194
CYP4BN12v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4D262110
65 amino acids from heme to end
71% to 4E2 (very short match), 64% to 4D2,
96% to CYP4BN12v2, 2 aa diffs
72% to CYP4BN1, 45% to 4D22, 51% to XM_967484
70% to XM_967484.1 PREDICTED: Tribolium castaneum 42% to 4D14
CYP4BN12v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD1553
62 amino acids from heme to end
68% to 4E2 short match, 61% to 4D2,
69% to 4BN1, 67% to CYP4BN13v1
CYP4BN12v3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
2 aa diffs to CYP4BN12v1
CYP4BN13v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD25180
64 amino acids from heme to end
57% to 4D2, 71% to 4BN3
71% to XM_961765.1 PREDICTED: Tribolium castaneum,
44% to 4D22, 47% to 4D23
56% to XM_966761.1, 52% to XM_967484
CYP4BN13v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD24810
61 amino acids from heme to end
54% to 4D2, 95% to CYP4BN13v1 (3 aa diffs), 68% to 4BN3
CYP4BN13v3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD29346
60 amino acids from heme to end
56% to 4D2, 95% to CYP4BN13v1 (3 aa diffs), 71% to 4BN3
CYP4BN13v4 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD61109
53 amino acids from heme to end
52% to 4D2, 96% to CYP4BN13v1, 69% to 4BN3
same aa seq as CYP4BN13v3, different nucleotide seq
CYP4BN14v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4D215Ic4
61 amino acids from heme to end
63% to 4D2, 64% to 4BN1 98% to CYP4BN14v2, 1 aa diff
CYP4BN14v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P4PD273ic4
61 amino acids from heme to end
61% to 4D2, 62% to 4BN1
CYP4BN15 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-12
58% to CYP4BN4 Tribolium castaneum, N-term half
CYP4BN fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-5
56% to CYP4BN4 Tribolium castaneum C-term
59% to CYP4BN12v1 Leptinotarsa decemlineata
too short to name yet
CYP4BP1X Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
46% to CYP4BM1 Tribolium castaneum
clone name EST MPB4B04
note 79% to CYP4BD1 so name changed to CYP4BD3
CYP4BQ1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
50% to 4AY1 full seq Ips paraconfusus
clone name EST DPG20G05
CYP4BQ1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
1 aa diff to CYP4BQ1 of Sandstrom
clone name DPO1017_M20
CYP4BQ1v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH1-1
89% to CYP4BQ1 Dendroctonus ponderosae (probable ortholog)
98% to CYP4BQ1v2
CYP4BQ1v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP4RH1-2
89% to CYP4BQ1 Dendroctonus ponderosae (probable ortholog)
98% to CYP4BQ1v1
CYP4BQ1v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4D-1
100% to CYP4BQ1v4
97% to CYP4BQ1v2
90% to CYP4BQ1 DPO1017_M20
CYP4BQ1v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP4D-2
100% to CYP4BQ1v3
97% to CYP4BQ1v2
90% to CYP4BQ1 DPO1017_M20
CYP4BQ2 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
54% to CYP4BQ1v3 Dendroctonus valens
CYP4BR1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966411, XP_975718 (missing an exon)
AAJJ01002884.1
53% to 4BR3, 45% to 4H11, 43% to 4D23,
6659 MILAIVIALISAPFIWWMLILSKYRSLSNVPGPKPSPVIGNSLHIGYRPQDLFNNIVKWAKEYGTVYKIF
VANDVRVLITNPELTELVLSSNVHITKSNAYDLLKPWLGIGLLIST GKKWKSRRKLITPTFHFKILDQFL
DVFNSCGNVLVQRLSSQVGKDSFDVYPFINLCSLDIIC ETSMGVKIKAQQGNNTEYVEAVRRFLDIFIIR
TFSVWKGIDALFKFSSAYSVYKRLLKILHQFTINIIVQRRGEKAQQKTQNVTSDDGIKRKVALLEMLLES
EDNNMLSNEDIREEIDTFMFEGHDT TTSGIAFAILCLAENPKVQEKLYEEVVAVIDNIENITMQQLQEMK
YLEMVLKEAQRLYPSV PVIERRLEVDCNIGGYDFPKDTFLSLFIYGMHHNEKYFPEPEKFDPNRYLPENQ
AKRHNYAYVPFSAGPRNCIGQKFAMLEMKTTIAKIVKHFKILPVPDYKPDLGIAAILKSYNGVCVRLQHR
HGN 8527
CYP4BR2P Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01002884 pseudogene between 4BR1 and 4BR3
9437 SGKKWKTRRKMITPTFHFKILDQFIEVFNSCGNVLVEKLSSHVGKESVDVYPFINLCS 9610
9699 TKRNGIKRKVAXXX
9737 MLLESEHNNVLSNEDIREEIDNFMIRG
9823 HDTTAFGIAFAILALADN
9876 PKVQDKVYGEILSVIGDYEDVTMQ*LQDSRYLEMVIKEA 9992
GGYDFPKDTAFSTFXXXXXXXXXX 10083
10082 FPNPEKFDPNIFLPENQS 10135
CYP4BR3 Tribolium castaneum (red flour beetle)
GenEMBL XP_967724
53% to CYP4BR1
MFVVAFFVTLTVILCTPLIWWYLTLAKYSSLKKVPGPPPLPVIGNSNVIGKTTVDLLHSFMNLQDKYGTV
VKVWLGPRLHLLITKPEMVEFFLNSTVHLNKSDGYDLFKPWLGDGLLVSTGSKWKTRRKLITPTFHFKIL
ENFLETSFNKQINILLDVLLKEASQTDKSIEIHSLINLCSLDIICETAFGTELNAQAKCNPKYVEAVTGF
LEIFTLRFFSAWLRHPLIFRLSDKYAKYMEYLKILHDFTNTIIKRRKEEFKLLQDNAKISEEGIKRRAAL
LDMLLEVSDNGKNLTDEDIREEVDTFMFEGHDTTTTSICFVLYAIAQNPDVQKKIYDELVSVLGPDCKKE
ITFSDIQELKYLDVVIKEAHRLYPPVPLIERSLEEDCTIDGLTIPKNTNISIFLYGMNYNKDVYPEPHVF
DPDRFLPEKQGERHTFAYVPFSAGPRNCIGQKFALLELKTTIAKLLRCFEISPDPKNPPQVGMCSVLKSR
NGIHMFLKKKN
CYP4BR4 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
56% to CYP4BR3 Tribolium castaneum
CYP4BS1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-2, 49% to 4C1 cockroach, 79% to CYP4BS2
Pediculus genome site
CYP4BS2 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-3, 48% to 4C1 cockroach, 79% to CYP4BS1
Pediculus genome site
CYP4BS3 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-4i, 71% to CYP4BS1
Pediculus genome site
CYP4BT1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-5, 42% to CYP4C3
Pediculus genome site
CYP4BU1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-6, 42% to 4C1 cockroach, 52% to CYP4BU2
Pediculus genome site
CYP4BU2 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-7, 52% to CYP4BU1, 38% to CYP4C1, 39% to 4AZ1 Apis
Pediculus genome site
CYP4BV1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph4-8, 41% to CYP4C3
Pediculus genome site
CYP4BW1 Ceratosolen solmsi martchali (fig wasp)
No accesion number
Dong-Guang Wan
Submitted to nomenclature committee July 9, 2007
54% to CYP4C25, 56% to CYP4C24 Orconectes limosus (crayfish)
partial seq from I-helix to heme
CYP4BW2 Ceratosolen solmsi martchali (fig wasp)
No accesion number
Dong-Guang Wan
Submitted to nomenclature committee July 9, 2007
95% to CYP4BW1, 55% to CYP4C24 Orconectes limosus (crayfish)
CYP4BW3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BW4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BW5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BW6 Linepithema humile (argentine ant)
No accession number
CYP4BW7 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
72% to CYP4BW6 Linepithema humile
CYP4BW8 Solenopsis invicta (fire ant)
EH413513 EST
81% to CYP4BW6 Linepithema humile
CYP4BX1 Daphnia pulex (Daphnia, water flea)
CYP4BX2 Daphnia pulex (Daphnia, water flea)
CYP4BX3 Daphnia pulex (Daphnia, water flea)
CYP4BX4 Daphnia pulex (Daphnia, water flea)
CYP4BY1 Daphnia pulex (Daphnia, water flea)
CYP4BY2 Daphnia pulex (Daphnia, water flea)
CYP4BY3 Daphnia pulex (Daphnia, water flea)
CYP4BY4 Daphnia pulex (Daphnia, water flea)
CYP4BY5v1 Daphnia pulex (Daphnia, water flea)
CYP4BY5v2 Daphnia pulex (Daphnia, water flea)
BQ703375 EST
Dauphin-Villemant, C., David, J-P, Mesneau, A., Meyran, J-C.
Submitted to nomenclature committee Feb. 27, 2002
Clone name 2.1 149 aa
58% to 4v3 mouse 59% to 4c24 66% to 4AN2
formerly CYP4AN3
renamed based on genomic full seq
CYP4BY6 Daphnia pulex (Daphnia, water flea)
CYP4BZ1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4BZ2 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4CA1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP4CB1 Liposcelis bostrychophila (psocid)
EU979550
Jiang Hongbo
Submitted to nomenclature committee Feb. 20, 2009
36% to CYP4C3 Droso., 37% to CYP4C37, 38% TO 4C61, 37% TO 4C62
40% TO EU979551, 41% TO EU979549, 37% TO 4BM1 Tribolium
MLGLLILLVIIFALVIGLDYYNHYKDPRRIIDRIFPGPFRIPIVGNALIAACSREAFYRVYLNLSKSYDYKPFRLWFLKQPYVFISDYENTKKILSSNDLLDKAEDYRYFEPWLGQGLLTSKGDKWRRDRKIITPAFHFQILHRFFQIFYDNGEIFCEKLTAHDGGDVFDVFEYIEMLTLDNLCNAALKLDIQAQLNPFSALVCAIQNMGVVIYNRIFTLWLRYDAMFRLSSTARLQKKCLEIIHGNDVKIIRERKEEMKTKQPKLKTMEFDEKEKVAFLDLLLEMQDDVGYTDEDIREQLDTFMFAGHDTVTATLGFLIYSLAEHPDVQEKVYRELLDIYGESERCPNFSDLQDMKYTEQVIKETLRLYTVVTAVARRVEEDFELSEHQVVPKGVEIVLLLSALHRNPEIFPNPDIFDPDRFSPEVNQERDSFAFVPFSAGSRNCIGQKFAMHEMKITVYKIVKKFKLSISDKPEDKVRTRTGVVLSSTNGIRIKVQSRKKKTPSKLADQ
CYP4CC1 Liposcelis bostrychophila (psocid)
EU979549
Jiang Hongbo
Submitted to nomenclature committee Feb. 20, 2009
39% to CYP4D22, 43% to CYP4D2, 40% TO 4C62, 39% TO CYP4C61
44% TO CYP4CD1, 41% TO CYP4CB1, 41% TO CYP4BN1 TRIBOLIUM
MIFYVIVTTILLLLYIKYRLTIRHLVVVDTMFPGPTCLPIIGNALMLRGTSEDFYKRFTETCFYYRRSFRVWIAHRLFIACLYPEDAEVILGNNFEITKADVYEFLLPWIGDGLITSTGKKWRTHRKMLTPAFHFRILEEFTKVFNKNGKIFCEVLSKIPENKIFDVYEYVKMYAMDNICETAMSVSINAQKNPNSAYIRAVKDMCTVAFKRMRTLWLRSDFLFRMSPWAKVHDDALSLIHSQTRDVIKKRKQELERNPDLRLTMENDNFSIKGKLAFLDILLHAAQEYRLTDEDIREEVDTFMFEGHDTITSAISFAMYYISRDQEVQKKILQETESIFRGEDREPTVKDFGAMKYLETVIKETLRLHPSVPFIARKISQDFQIDMKAYAPRGAEVLVVIAALHRNPYQWEKWDQFYPEHFLPEATQKRHPYSFVPFSAGPRNCIGQKFAMIEMKSVLSKVVKEFELIPSPHPEHAIREVPDLILTSGTGMHVGLRKRISGAA
CYP4CD1 Liposcelis bostrychophila (psocid)
EU979551
Jiang Hongbo
Submitted to nomenclature committee Feb. 20, 2009
47% TO CYP4BN6 TRIBOLIUM,
42% to 4D17, 43% to 4D2, 41% to CYP4C62, 39% to 4C61
44% TO CYP4CC1, 40% TO CYP4CB1
MVLHGLFVTFVCATLIYVLERIIHRRVYKAEKQFDGPPGYWFFGNSFDFINKSSKEIFDQVVENLKTYGNGRFYKIRIMHRLGIACSDHRDMEVILGSNTLIDKGVHYHFILPWIGFGPLTSNGSRWRKHRKIITPTFHFKILEQFIDVFNKNGAIMCEKMEKEVNGEPFNVYNYVNLAALDNIFESAMGINMNVQKNSETTYVRAIKEMCNVVNKRVFWWILRIYPIFRLSKYYKMQTDALNVLHSTTVNIIEQRKKELAVRKKLEKDDEKDEEIEFYQKKRMAFLDLLLESAEASNISDEDIRQEVDTFMFEGHDTISSGLSFALWALANNPDVQQKVYEEQMEIFGDSNRPPTFNDLQNMKYLERTLKESQRLFPSVPMITRKLNEDVDLPGGYHLPKGTNVGMIIYSLHRDPKVWPNPEKFDPDNFTPDAIQGRNPYSYVPFSAGPRNCIGQKFAMLEMKSTVSKVVRQYKLLPSPYEKHKLQLTSELVLMSLSGVHVKIQRRSNSFS
CYP4CE1 Nilaparvata lugens (Homoptera: Delphacidae)
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: BPH4-8
38% to CYP4AZ1 honeybee, 42% to Cyp4c3 Drosophila
43% to Nilaparvata lugens CYP4C61, 41% to Nilaparvata lugens CYP4C62
CYP4CE2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
87% to CYP4CE1 Nilaparvata lugens
CYP4CF1 Panonychus citri (citrus red mite)
FJ480404
47% to CYP4V2 human
CYP4CF2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP4CG1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
Confidential, formerly CYP4M3 (fragment)
CYP4CG2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4CG3 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP4CG4 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
54% to CYP4CG1 Manduca sexta
CYP4CG5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
55% to CYP4CG1 Manduca sexta
CYP4CG6 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
49% to CYP4CG1 Manduca sexta
CYP4CG7 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
49% to CYP4CG1 Manduca sexta
CYP4CG8 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP4CG6 Heliconius melpomene
CYP4CG9 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP4CG11 Heliconius melpomene
CYP4CG10 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP4CG9 Heliconius melpomene
CYP4CG11 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP4CG9 Heliconius melpomene
CYP4CG12 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
84% to CYP4CG11 Heliconius melpomene
CYP4CG13 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
47% to CYP4CG1 Manduca sexta
CYP4CH1 Acyrthosiphon pisum (pea aphid)
LOC100167623p SCAFFOLD15279:22883..50385 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
70% to LOC100163721
small duplication near C-term
CYP4 clan
MWYLTVITPIAILVVIIMILRLEGRRKRVLANKIPGPDGSIFIGMLPLFLQGPEQLILKGLKVYQKYEKSLFKVWVLNNLYIVLTRPEDIEMVLTNPKLQKKSKEYLVLQESIMGQGIFSIDDIKKWKSNRKMVSGGFNFTIIKSFIPIFYEESNVLNDILKQKCDLKSNECDISVPVSMATMEMIGKTALGVKFNAQNGGRHRFVENLQTAMHAWEYRISHP
WYLSKTLFQLSSVKKKHDQSQKIINEFTDEIINKKLDELNQNANN
KNKVETDDEDVCRKTKTVIEILLGNYHEMSHEQIRDELVTIMI
GGQETTAMANACAIFMLAHHPDVQNKVFEELQSIFSTGDHNRPPTYEDLQQMEYLERVIKETLRIFPPLPVFGRSLEEEMKIGEHLCPAGSTLMVSPLFVHSSGQYYTDPEKFNPDNFLPDTCRGRHPYSFIPFSAGYRNCIGIKYG
ILQMKTVISTLVRK
NTFSPSERCPTPKHLRVMFLSTLKFVDGCYVKIVPRTS*
CYP4CH2 Acyrthosiphon pisum (pea aphid)
LOC100167777p SCAFFOLD9588:3006..11080 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
30% to CYP4G7
missing N-term, might be a pseudogene
CYP4 clan
YEKSMFKAWLFNKLYIVLTRPEDIEFVLASPKFLRKAKEYMVLQQSIMGQGIFTIEDINKWKINR (2?)
XXXXXXXXXXXXXXXXXXXXXXXXVLAEILGD NSDSTSKECDISVPVSMATMEMIGKTALGVTFNAQKGGCNRFVENLLTAMHAWEYRITHPWYLSSTLFQFSSIKQKHDHSQKIINEFTDEIIKSKIVEINNSGSENGVNADDDDIGRNTKTLTKIFLENPHENMTLEQIRDELVTVMIGGQETTAMANACVVFMLAHHQDVQDKVFKEQESIFSIGDRNRPITYNDLLQMEYLERVIKETLRLFPPLPVFGRDLNEDTTIGDHLCPAGSTLIICPLFLHSSPQHYGSTAHGPDAFDPDNFLPEACHERHAYAYIPFSTGPRNCIGIKYAMLQMKTVASTLVRHHRFLPSDRCPTPDQLRLVFLTTLKLADGCYVKVEPRRPQ
CYP4CH3 Acyrthosiphon pisum (pea aphid)
LOC100163721 SCAFFOLD9588:25696..30352 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
revised middle
70% to LOC100167623p, downstream of LOC100167777p
CYP4 clan
MXXXXXXXXXXXXXXXXXILVITIVILILKGRKNRILANRIPGPNGWFLVGMLPLFLQGPEKLIKNILREYRIYEKHIVKFWLFNNLYIVLTRHQDIELVLGNPKFLRKSKDYMVLQESIMGQGIFSIDDIEKWKNNR
KMVMKGFNFTPTKSFIPIFYQEAN
VLAEILQEKCVLKSNECNISGPVSMATMEMIGKTALGVTFNAQTGGCNQFVEHLQTAMHAWEYRVTHP
PWYLNNTLFRFSSVKREHDRSQKIINKLTDEIIKQKIIELSQNINNS
EKKIESDNEECCQKSKTVLEILLGSSHKMDHEQIRDEIVTVMI (1)
GGQETTAMAITCTIFMLAHHQDVQNKVFEELQSIFVNGDRNVPPTYKDFQQMKYVEMVIKETLRLFPPLPFLGRRLDEDMKIGEYMCPAGAALIICPIFVQSSPLYYTDSEKFNPDNFLPDACGSRHSYAYIPFGAGLRNCIGIKYAMLQIKTVISTLVRK IKFSPSERCPTPEDLRLMFLMTLKLVDGCYIKMEPRT
CYP4CJ1 Acyrthosiphon pisum (pea aphid)
LOC100166760.pro SCAFFOLD7010:99236..111631 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP4 clan
MIFSNVIGALTSDSNTQWMALLSLVVLGVYFLFSDRFSENRGRQISLLPSITRSQWTSLILSLKLASFGPRDILPYFDNVIKKYGSLIHLKIIARHYIIINDPDDIKVLLSSVQHITKGPDYEMLEPWLNKGLLTSTDQKWHSRRKLLTNTFHFKILETYVPSLNKHSRSLVKNLINASDNGKSIADIDSHVTLCALDIVCETIMGVNLRTQEGKSMNYVKAIKNVSQILIKRIFTFWYWNEIVFNLSSIGREFRKSLKLLHDFTENVIRERRKILENVEQKKVDENGKKRIYSFLDLLVGVSKENPGAMTDKDIREEVDTFLFEGHDTSSIAITMAIIHLGLDQNIQNLVRDELYEIFGDSDRDATMEDLKAMTNLERVIKETMRLYPSVTGITRTLKQPLHLDKYTIPSKSVMVVVPHLLHRDKNIYPNPEKFDPDRFLPEQCNGRHPYAYIPFSAGPRNCIGQKFAMYQMKTVLSTILRYTNVETLGTQKSIVISTQLILRADYLPSGVRDFPVKSFSLV
CYP4CJ2 Acyrthosiphon pisum (pea aphid)
LOC100164743.pro SCAFFOLD7010:120446..129462 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
adjacent to LOC100166760.pro
CYP4 clan
MLETNVYNFVLIPLAILISYAIWSRLRKPLEYRQISSHVPSVTKNLWSELLFSCSIAMKHPRDLLPFFMEIFLNNGPVVHCNITGRSYVLLNDPDDIKILLSSTQYINKGPEYKMLKPWLNDGLLLSSGLKWQNRRKLLTNTFHFKTLDMYNPAVNKHAKVFTKKLLEACEDDKEISVMEYVTLCSLDIICETIMGTEMNAQKGKSIQYVYSIKSACRSVIDRVFKFWLWNDLIYRISESGRSFFKSIRVLHDFTDSVIKRKQSLLKTSGNTIVQPESKPAEKRKTKSFLDLLLDVLKDNPDQMTIKDIREEVDTFLFEGHDTSSISMTMTLLLLGMHQDIQDRAREELHSIFGDSDRDATMEDLNAMRYLDAVIKESLRLYPSVPSFTRELETTLQLENYKIPPMTTMVIFPYILHRNENIFPKPEDFIPERFLDEDNKSKFLFGYIPFSAGARNCIGQKYAMNQMKTVVSTVLRNAKIVSSGCKEDIKISMQLLIRIESLPKVIFRPL
CYP4CJ3 Acyrthosiphon pisum (pea aphid)
LOC100162661.pro SCAFFOLD7010:131616..139794 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
41% to CYP4C3 adjacent to LOC100164743.pro
CYP4 clan
MIEVNFYSVVLVPLAGLISYAIWSRLRMPVEYRQISSHVPSVTKSFWSEMVLSWKLAMLQPK
DILPFVTDLFKENGPVVHFNLSGRSYVLLNDPDDLKVLLSNTQYIKKGPEYEMLKPWLNEGLLLSSGQKWHNRRKLLTNTFHFKTLDMYNPSINKHSRILVDKLFEASANDDKEISIAEYVTLCSLDIICETIMGTEMNAQKGKSAEYVHSIKSACKSVIERIFKFWLWNDLVFRMSGSGQSFFKSIKILHEYTDNVIKSKRASLNNSGIEKIRSDSKFEKTKKKSFLDLLLNVLNDTPDQMSDRDIREEVDTFLFEGHDTSSIAMTMILVLLGMHPEIQDRARDELRSIFGYSTRDATMEDLNAMKYLEAVIKESLRMYPSVPAFTRELDKPLQLNKYIIPPMTTITVYPFILHRNEDIYPDAEEFIPERFLDEENKAKFIFGYLPFSAGARNCIGQKYAMNQMKIVVSTILRNAKFESLGRKEDIQISTQLIIRIESLPKMKFYKL
CYP4CJ4 Acyrthosiphon pisum (pea aphid)
LOC100160629 SCAFFOLD7010:141476..155172 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
adjacent to LOC100162661.pro
CYP4 clan
MIEVNFYSVVLMPLAGLISYAIWSRLRMPVEYRQISSHVPSATKTFWSEMVLSWKLAMMQPK
DILPFLTDLIRNNGPVVHFNLSGRSYVLLNDPDDLKILLSNTQNIKKGPEYEMLKPWLNEGLLLSSGQKWHNRRKLLTNTFHFKTLDMYNHSINKHSRILVDKLLDASANSNKEISIADYVTLCSLDIICETIMGTEMNAQEGKSVQYVHSIKCACKSVIERIFKFWLWNDLIYKISGSGQSFFKSIKALHEFTDNVIKSKRALLNNSGIEEMQSDKKTKKKSFLDLLLNVLNDTPDQMNDRDIREEVDTFLFEGHDTSSISMTMTLVLLGMYPDIQDRARDELHSIFGDSDRNATMEDLNAMKYVEAVIKESLRLYPSVPGITRELQTPLQLKNYIIPPMTTIAVYPFILHRSENIYPNAEEFIPERFLDEENKAKFQFGYLPFSAGARNCIGQKYAMNQMKIVVSTILRNAKFESLGSKEDIQISTQLVLRIESLPKMKFFNL*
CYP4CJ5 Acyrthosiphon pisum (pea aphid)
AUG5s3079g1t1 SCAFFOLD3079:13926..21110 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
64% to LOC100166760.pro
43% to CYP4CE1, 43% to 4V16, 42% to 4C1
missing the N-term
CYP4 clan
DVLPFLSSILKQHGSLVHIHLLGHSYVLLNDPNDIKVLLSSPQHINKGPEYGLLKPWLNKGLLTSGSQKWQMRRKLLTYTFHFKILETYISSFNKHAQCLTKKLENMASNNQRVSIYTHMTLCALDLVCDTIMGTELRSQEGKSLEYVEAINTVTDITIKRIFKFWLWNGSIFNLSQIGRDFNKSLKILHTFTENVIKEKRAKLESVNCLETEELSFGKKRVESFLDLLIGISKQNPEKMTDMDIREEVDTFLFEGHDTSSTAMTMAFIQLGLNQDIQNSVREELYSIFGDSDREATMADLKSMTYLDRVIKETIRLYPSVPSVTRMLRQHLHIKEYDIPPQTVVVVVPYLLHREEKHFPNPLTFDPDRFLPEHSINRHPYAFIPFSAGPRNCIGQKFAMYQMKTIISTVIRKMKIETLGSQDDIKISAQLILRPESLPDIKLTKIK
CYP4CK1 Acyrthosiphon pisum (pea aphid)
LOC100161405.pro SCAFFOLD15733:160611..183325 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
47% to CYP4BT1 Pediculus humanus
CYP4 clan
MNYHDHLTTRSRHCTTTVEEINDVERDDYNRSPLPLSTSGILIRTVEPILATVSLVFDKSFILFACFSKFSLQYFNELYLFLCQLLVDLHFFRLLLEWHSKFGDTYQLWIGLRPFIAMANADHIQQILKSTVHIDKNLEYNLLLPFIGTGLVTSSGSKWHTRRKLLSPTFHQNILEGFLPLIEKQMKTLVKVLRKEVNNVNGFDIKPYAKLAALDTIGNTAMGCEINSQENSQLDYVKALDELTAIMQKRFITPWLKPNLLFNLTSLSKRQKACIDVIHTFTRKVIKERKDNFKLFNNQTSDANKNEIHYEKKPNRALLDLLIEVSEDGKVLSDEDIQEEVDTFMFAGVDTTSVTLSWVMYVLGKHPHVQDKIVEELNQKIPNFGDGNLTLNILSSLDYLGRTIKEVLRLYPSVPFIGRQIYQPLTIGDHTILPGTSIFINVFALHRNEKHFENPEKFDPDRFLKEKKNDRHRFAFVPFSAGSRNCIGQKFAMIVLKIAVATVIKTYRVKSIDPEEKLGLVGEIVLNALNGIHVTLEERT
CYP4CL1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP4CL2 Panonychus citri (citrus red mite)
JQ690089
Tian-bo Ding
Submitted to nomenclature committee Feb. 26, 2012
94% to CYP4CL1
CYP4CM1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig11893 491aa
47% TO CYP4CJ1 aphid, in the CYP4 clan
CYP4CN1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig6889 501aa
40% TO CYP4BR1 Tribolium, in the CYP4 clan
CYP4CP1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig7689 509aa
43% TO CYP4D23, in the CYP4 clan
CYP4CQ1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig3337 502aa
40% TO CYP4D24, in the CYP4 clan
CYP4CR1 Trialeurodes vaporariorum (whitefly)
confidential
CYP4CS1 Trialeurodes vaporariorum (whitefly)
confidential
CYP4CS2 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
52% to CYP4CS1 Trialeurodes vaporariorum (whitefly)
CYP4CS3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
58% to CYP4CS1 Trialeurodes vaporariorum (whitefly)
CYP4CS4 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
60% to CYP4CS1 Trialeurodes vaporariorum (whitefly)
CYP4CS5 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
54% to CYP4CS1 Trialeurodes vaporariorum (whitefly)
CYP4CT1 Trialeurodes vaporariorum (whitefly)
confidential
CYP4CU1 Ummeliata insecticeps (spider)
No accession number
Zhifan Yang
Submitted to nomenclature committee March 27, 2010
45% to CYP4C55 Daphnia pulex
first spider P450
confidential
CYP4CV1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
46% to CYP4BM1 Tribolium castaneum (red flour beetle)
clone name DPO0110_J19
CYP4CV2 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
76% to CYP4CV1 Dendroctonus ponderosae
CYP4CW1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-2
41% to CYP4BR1 Tribolium castaneum (new CYP4 subfamily)
CYP4CX1 Linepithema humile (argentine ant)
No accession number
CYP4CX2 Linepithema humile (argentine ant)
No accession number
CYP4CX3 Linepithema humile (argentine ant)
No accession number
CYP4CX4 Linepithema humile (argentine ant)
No accession number
CYP4CX5 Linepithema humile (argentine ant)
No accession number
CYP4CX6P Linepithema humile (argentine ant)
No accession number
CYP4CX7 Linepithema humile (argentine ant)
No accession number
CYP4CX8 Linepithema humile (argentine ant)
No accession number
CYP4CX9 Linepithema humile (argentine ant)
No accession number
CYP4CX10 Linepithema humile (argentine ant)
No accession number
CYP4CY1 Linepithema humile (argentine ant)
No accession number
CYP4CY2 Linepithema humile (argentine ant)
No accession number
CYP4CY3 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
64% to CYP4CY2 Linepithema humile
CYP4CZ1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
Formerly CYP4CX1 but name conflict required a change
46% to CYP4C7 Diploptera punctata
CYP4DA1 Diaphorina citri Kuwayama (Asian citrus psyllid)
No accession number
Siddharth Tiwari
Submitted to nomenclature committee April 7, 2011
50% to CYP4C10 Coptotermes acinaciformis
CYP4DB1 Diaphorina citri Kuwayama (Asian citrus psyllid)
No accession number
Siddharth Tiwari
Submitted to nomenclature committee April 7, 2011
49% to CYP4G60 whitefly
CYP4DC1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
40% to CYP4U3 Reticulitermes flavipes (termite)
CYP4DC1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
40% to CYP4U3 Reticulitermes flavipes
gene 11 plus P22 make a complete sequence
CYP4DD1v1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
44% to CYP4C61 Nilaparvata lugens (brown planthopper)
CYP4DD1v2 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
45% to CYP4C61 Nilaparvata lugens (brown planthopper)
2 amino acid diffs to CYP4DD1v1
CYP4DD1v2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
More complete but still missing the N-term
CYP4DE1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
45% to CYP4C61 Nilaparvata lugens (brown planthopper)
CYP4DE1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
complete
CYP4DF1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
43% to CYP4CX9 Linepithema humile
Formerly CYP4DC1, but name conflict
CYP4DF2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
47% to CYP4CA1 Nasonia, 77% to CYP4DF1
Formerly CYP4DC2, but name conflict
CYP4DF3 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
48% to CYP4CA1 Nasonia, 77% to CYP4DF1
Formerly CYP4DC3, but name conflict
CYP4DG1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
47% to CYP4J18 Culex pipiens, 61% To CYP4DG2
CYP4DG2 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
44% to CYP4J18 Culex pipiens, 61% To CYP4DG2
CYP4DH1 Locusta migratoria manilensis
No accession number
Ren Xiaoyu
Submitted to nomenclature committee Nov. 8, 2011
49% to CYP4U3 Reticulitermes flavipes (termite)
CYP4DJ1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 39% to CYP4U3 Reticulitermes flavipes,
38% to CYP4C1 cockroach
CYP4DK1v1 Plutella xylostella
Gene number CCG004951.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
98% to CCG005621.2, 6 aa diffs in overlap
38% to CYP4BN1 Tribolium castaneum
CYP4DK1v2 Plutella xylostella
Gene number CCG005621.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Missing N-term 89 aa
CYP4DL1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL3P Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL4-de3b Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DL5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DM1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DN1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DN2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DP1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DP2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DQ1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DR1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS8 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS9 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DS10 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DT1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP4DU1X Perinereis nuntia (polychaete worm)
No accession number
Eun-Ji Won
Submitted to nomenclature committee Feb. 16, 2012
54% to CYP4BK3, 50% to CYP4BK1
60% to CYP4BK4 Capitella teleta
renamed CYP4BK5
CYP4DV1 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
50% to CYP4BH1 Ips paraconfusus, 51% t0 CYP4BN6 Tribolium
missing N-term
CYP4 fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP4 clan
Clone name seq 2
60% to CYP4AK1 Diabrotica virgifera
too short to name EXXR to PKG fragment
CYP4FA1 Coscinasterias muricata Australian sea star (11 armed starfish)
GenEMBL AF163824
Georgiades,E., Holdway,D., Wu,Q.K., Brennan,S., Butty,J. and
Temara,A.
The impact of oil-derived products on the biology of the
eleven-armed asteroid Coscinasterias muricata
Aquatic Toxicol. (1999) In press
partial seq. from I-helix to heme
Given its own subfamily renamed CYP4FA1
Old name CYP4F20
CYP4FA1 Coscinasterias muricata Australian sea star (11 armed starfish)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
3 aa differences with AF163824 from I-helix to heme region
partial seq. from I-helix to heme
CYP4 Caenorhabditis elegans (nematode worm)
CEMSH91R
C-terminal fragment with coding region identical to wEST00713
CYP4 fragment. Region before translated "AGPRNCIG" may be an
intron sequence.
The complete gene of this fragment is CYP29A2, probably a 4 family
equivalent in C. elegans.
5A Subfamily
CYP5A1 rat
GenEMBL D28773
Tone,Y. et al.
unpublished
submitted to Nomenclature Committee
CYP5A1 rat
GenEMBL S69335 (1849bp)
Tone,Y., Miyata,A., Hara,S., Yukawa,S. and Tanabe,T.
Abundant expression of thromboxane synthase in rat macrophages
FEBS Lett. 340, 241-244 (1994)
Cyp5a1 mouse
GenEMBL L18868 (1856bp) Swiss P36423 (533 amino acids) AC073390.1
PIR JN0683 (533 amino acids)
Zhang,L., Chase,M.B. and Shen,R.-F.
Molecular cloning and expression of murine thromboxane synthase.
Biochem. Biophys. Res. Commun. 194, 741-748 (1993)
Note: ExxR sequence in K-helix is ETLS. The S deviates from an
extremely highly conserved R at this position.
MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGI
RHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVE
NFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACE
LLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRAST
FCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRR
DFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQ
AFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPY
LDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPET
FDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPET
QVPLQLESKSALGPKNGVYIKIVSR
Cyp5a1 mouse
GenEMBL U41326 to U41337 and U41397 (genomic sequences)
Zhang,L. and Shen,R.-F.
unpublished (1996)
CYP5A1 Cavia porcellus (guinea pig)
AAD20319
1 DMIKQVLVEN FSNFTNRMAS GLEPKPVANS ILLLRDKRWE EVRGVLTSVF SPEKLNEMIP
61 LISQACDLLL AHLRRCAESG NACDMQRYYR AFATDVVASV AFGTRVDSQK DPEDPFVLHC
121 RRFFAFSMAR PLLVLILSFP SIMVPLARIL PNKNRDELNH FFTELXRNVI A
CYP5A1 Sus scrofa (pig)
GenEMBL L13128 (1789bp)
Shen,R.-F., Zhang,L., Baek,S.-J., Tai,H.-H. and Lee,K.-d.
Porcine thromboxane synthase complementary DNA: cloning,
expression, and sequence comparison.
Gene 140, 261-265 (1994)
CYP5A1 human
GenEMBL M74055 (687bp) PIR JN0074 (245 amino acids)
Wang,L.-H., Oshashi,K. and Wu,K.K.
Isolation of partial complementary DNA encoding human thromboxane
synthase
Biochem. Biophys. Res. Commun. 177, 286-291 (1991)
CYP5A1 human
GenEMBL M80646 (1719bp) M80647 (1882bp)
PIR A41766 (534 amino acids)
Ohashi,K., Ruan,K.-H., Kulmacz,R.J., Wu,K.K. and Wang,L.-H.
Primary structure of human thromboxane synthase determined from
the cDNA sequence.
J. Biol. Chem. 267, 789-793 (1992)
M08646 is truncated M08647 is functional.
CYP5A1 human
GenEMBL S70152 (1753bp)
Lee,K.-d., Baek,S.-J. and Shen,R.-F.
Cloning and characterization of the human thromboxane synthase
gene promoter.
Biochem. Biophys. Res. Commun. 201, 379-387.
exon 1 and promoter
CYP5A1 human
GenEMBL S51388 (1910bp)
Yokoyama,C., Miyata,A., Ihara,H., Ullrich,V. and Tanabe,T.
Molecular cloning of human platelet thromboxane A synthase.
Biochem. Biophys. Res. Commun. 178, 1479-1484 (1991)
CYP5A1 human
GenEMBL D34614 to D34625
Miyata,A., Yokoyama,C., Ihara,H., Bandoh,S., Takeda,O.,
Takahashi,E.-I. and Tanabe,T.
Characterization of the human gene (TBXAS1) encoding thromboxane
synthase
Eur. J. Biochem. 224, 273-279 (1994)
CYP5A1 Pan troglodytes (chimpanzee)
XM_003318833
TBXAS1
EXTRA EXON REMOVED FROM TRANSLATION
98% (6 AA DIFFS) TO HUMAN
MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLG LRHPKPSPFIGNLTFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLV ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNE
MVPLISQACNLLLAHLKRYAE
SGDAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLL LSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARH SASPMGVQDFDIVREVFSSTGCKPNPSRQHQPSSMARPLTVDEIVGQAFIFLIAGYEI VTNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLKEGLPYLDMVIAETLRM YPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEAR QQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSA
LGPKNGVYIKIVSR
CYP5A1 Macaca fascicularis (cynomolgus monkey)
AB220392
MMEALGFLKLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLG
LRHPKPSPFIGNLMFFRQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLV
ENFSNFTNRMASGLEFKSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMTPLISQAC
DLLLAHLKRYAESGDAFDIQRCYRNYTTDVVASVAFGTPVDSQQAPEDPFVKHCKRFF
EFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERR
RDFLQMVLDARHSASPVGVQDFDMVGDVFSSTRCKPNPSRQHQAGPMARPLTVDEIVG
QAFIFLIAGYEIVTNTLSFATYLLATNPDCQEKLLREVDLFKEKHMVPEFCSLEEGLP
YLDMVIAETLRMYPPAFRFTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPE
TFNPERFTAEAQQQHRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFQFQACPE
TQVPLQLESKSALGPKNGVYIKIVSR
CYP5A1 Bos taurus (cow)
See cattle page for details
94 MEVLGLFRLEVSGPMVTVALSVVFLALLKWYSTSAFSRLEKLGIRHPKPSPFIGNLAFFRQ 276
277 GFWESHMELRKQYGPLSGYYLGRLMFIVISEPDMIEQVLVEKFSNFTNRMAT 432
433 GLEPKPVADSVLFLRDKRWEEVRSVLTVAFSPEKLSEMTPLISRACDVLLAHLERH 600
601 AQSGEAFDIQKTYCCYTTDVVASVAFGTEVNSQEAPEHPF 720
VEHCRRFFASSIPKPLLVLLLSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQ
AAEERRRDFLQMVQDVRHSAATVGVENFDIVRQVFSATKCPANPPRRHSPRPLSKP
1069 LSVDEVVGQAFIFLIAGYEIVTNTLSFATYLLATNPECQEKLLEEVDCFSKEHLAPEYCS 1248
1249 LQEGLPYLDMVIKETLRMYPPAFRFTRVAAQDCEVLGQRIPAGAVLETAVGALHYDPE 1422
1423 HWPNPENFNPERFTAEAQQRRRPYTYLPFGAGPRSCLGVRLGLLELKLTLLHILRKFR 1596
1597 FEACPETQVPLQLESKSALGPKNGVYIRIVSR*
CYP5A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
82% to human 5A1, one aa diff to NM_214046.1
Ortholog of human CYP5A1
CYP5A1 Sus scrofa (pig)
NM_214046.1
82% to human 5A1
MEVLGFLSPELNGPMVTMALAVVLLALLKWYSTSAFSRLEKLGI
RHPKPSPFIGNLTFFRQGFWESHMELRKQYGPLSGYYLGRRMIVVISDPDMIKQVLAE
KFSNFTNRMATGLESKPVADSILFLRDKRWEEVRSVLTSAFSPKKLNKLTPLISQACD
LLLAHLERYAESGDAFDIQRCYCCYTTDVVASVAFGTQVNSSEEPEHPFVKHCRRFFA
FSVPRLILVLILSFPSIMVPLARILPNKKRDEVNGFFNKLIRNVIALRDQQAAEERRQ
DFLQMVLDLRHSAPSVGVENFDIVRQAFSSAKGCPADPSQPHLPRPLSKPLTVDEVVG
QAFLFLIAGYEIITNTLSFVTYLLATNPDCQEKLLREVDDFSKKHPSPEHCSLQQGLP
YLDMVLSETLRMYPPAFRFTREAARDCEVLGQRIPAGTVLEVAVGALHHDPKHWPHPE
TFDPERFTAEAQRLQQPFTYLPFGAGPRSCLGVQLGLLEIKLTLLHILRKFRFEACPE
TQVPLQLESKSALSPKNGVYIRIVPR
CYP5A1 Canis familaris (dog)
XM_539887.2
MEVLSFLKLEVNGPMVTVALSVVLLALLKWYSTAAFSRLEKLGI
RHPKPSPFIGNLPFFCQGFWESQMELRKLYGPLCGYYLGRRMFIVISEPDMIKQVLVE
NFHNFTNRMVSGLESKPVMDSVLFLRDKRWEEVRSVLTSAFSPEKLNEMTPLISQACD
LLLAHLKHYAESGDAFDIQRCYSCYTTDVVASVAFGTQVDSRRAPGDPFVKHCRRFFA
YSIPRPILVLILSFPSIMVPLARILPNKNRDELNGFFNKLIRNVIALRDQQAAEERRR
DFLQLILDARHLATSLGVDSFDMVRQVFSSTDCTVGPSRPHQPRHLSQPLTLDEIVGQ
AFIFLIAGYEIITNTLSFATYLLATNPDCQEKLLAEVDSFKEKYTALDYCSLQEGLPY
LDMVIAETLRIYPPAFRFTREAARDCEVRGQRIPAGAVVEVAVGALHRDPEYWPQPET
FNPERFKAEAQRRQQPFTYLPFGAGPRSCLGVRLGLLEVKLTLLQVLHQFRFEACPET
QVPLQLDSKSALGPKNGIYIKIVSR
CYP5A1 chicken
XP_416334, 63% to human CYP5A1
1 MAAQPSAAAL TLTLSSAAEG WPMLQRGDAG RWQEDGGLVS FQGGNYIPCD KYSTSAFSKL
61 SKVGIRHPPP LPFIGNLLFF REGFWENHTK LITEYGPVCG YYIGRQMFVV ISTPEVIKQI
121 LVTDFGNFTN RTKPNLISKP MLDSILCLRD ERWKYVRSLL TPAFSDAKLK EMIPLINQAC
181 DVLLSNLKVY ADSGRAFDIQ RCYNCFTLDV VGSVAFGTEV DSQKNPDDPF VKNCRTFFEM
241 SLFKPLLFLI LSFPFIMIPL LRILPNKKQK ELNGFFIQTI KNAIAFRDQQ DAAERRRDFL
301 QWMLDSRNSA DALAGGYFDQ ICPATTSSHN EVPLVDKTPS EKAQKMLTED EIAGQAFLFL
361 IAGYETTTST LSFATYLLAT NPECQEKLLQ EIDEFSAKHM AQDLCALEEN LPYLDMVIAE
421 TLRMFPPAFR FTREAAKDCV VLGQRIPAGA VIETAVGHLH HNPEFWPEPE KFIPERFTEE
481 AKKERHPFAY LPFGAGPRGC IGRKMGLLAT KMTLLRILQM FRFKTCPETE IPLQLKSKAT
541 LGPKNGVYII LESR
CYP5A1a Xenopus laevis (African clawed frog)
BC060001.1
92% to X. tropicalis CYP5A1
MEEPTLWGLDGCTVTFALVAGFLGLLYWYSVSAFSQLDKVGIKH
PKPLPFIGNVMLFKKGFWEGDRHLIKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDF
VNFTNRMKLNLVTKPMSDSLLCLRDDKWKRVRSVMTPSFSAIRMKEMCPLINQCCDVL
VDNLLEYASSGEACNVQRCYACYTMDVVASVAFGTQVDSQRDPDHPLVQNCKRFLELF
TPFKPLILLCLAFPSIMIPIARRLPNKQRDRINSFFLKVIRDIIAFRENQPPNERRRD
FLQLMLDAQDSVSHVTVDHFDIVNQADLSVPQNSPSEKQDRGQDPPRKSSKKLNKEEI
LGQAFIFLIAGYETTCSLLSFTSYLLATHPDCQEKLLKEVDEFSQEHKEADYNTVHDL
PYMDMVINETLRMYPPAYRFAREAARDCTVMGQNIPAGAVVEIPIGCLQNDPRFWHEP
EKFNPERFTAEEKQKRHPFLFLPFGAGPRSCIGMRLALLEAKITLYRVLQKFRFQTCD
LTQIPLQLSAMSTLRPKDGVYVTVVAR*
CYP5A1b Xenopus laevis (African clawed frog)
SwissProt Q6PCI4
93% to CYP5A1a X. laevis, 90% to CYP5A1 X. tropicalis
ohnolog due to genome duplication in X. laevis
MEMLRLWGLDGCTVTFALVAGFLGLVYWYSVSAFSQLEKVGIKHPKPLPFIGNVMLFQK
GFWEGDRHLLKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDFVNFTNRMKFNLATKPM
SDSLLCLRDDKWKRVRSVLTPSFSAIRMKEMCPLINQCCDVLVDNLQEYASSGEACNVQ
RCYACFTMDVVASVAFGTQVDSQKDPEHPLVQNCKRFLEQFTPFKPLVLLCLAFPSIMI
PIARRLPNKQRDRINSFFLKVIRDIIAFRENQPPNERRRDFLQLMLDARDSAGHVTVDH
FDIVNQADLSVPRNSPSEKQDRGQDSPRKSTKKLNEEEILGQAFIFLIAGYETTCSLLS
FASYLLATHPECQKKLLREVDEFGREHKEADYNTVHELPYMEMVINETLRMYPPAYRFA
REAARDCTVMGLNIPAGAVVEIPIGCLQNDPRFWHEPEKFNPERFTAEEKQKRHPFLFL
PFGAGPRSCIGMRLALLEAKITLYRILKNFRFQTCDLTQIPLQLSAMSTLRPKDGVYVR
VVAR
CYP5A1 Xenopus tropicalis (Western clawed frog)
CX843268.1 CX920105.1 CX846214.1
BC159143 cDNA
scaffold_1778:46661-92162 UCSC Browser
54% to CYP5A1 human
missing last exon in seq gap, not in ESTdb or UCSC genome browser
Trace archive 414884422, 418775930
MGESWLWGLDGCTVTLTLVAGFLGLLYWYSVSAFWQLEKAGIKHPKPLPFIGNI
MLFQKGFWEGDRHLLKTYGPICGYYMGRRPMIVIAEPDAIKQVLQKDFVNFTNRMRLNLV
TKPMSDSLLCLRDDKWKRVRSVLTPSFSAARMKEMCPLINQCCDVLVENLMEYASSGEAC
NVQRCYACFTMDVVASVAFGTQVDSQRDSDHPLVQNCKRFLELFTPFKPVVLLCLAFPSI
MIPIARRLPNKHRDRINSFFLKVIRDIIAFRENQPPNERRRDFLQLMLDAR
DSAGHVSVDHFDIVNQADLSVPQNQDRGQDPPRKSTQKTLNEEEILGQAFIFLIAGYETT
CSLLSFASYLLATHPDCQEKLLKEVDEFSQEHEEADYNTVHDLPYMEMVINETLRMYPPA
YRFAREAARDCTVMGLGIPAGAVVEIPIGCLQNDPRFWHEPEKFNPER (2)
FTAEEKQKRHPFLFLPFGAGPRSCIGMRLALLEAKITLYRVLRKFRFQTCDLTQ (0)
IPLQLSAMTTLRPKDGVYVRVVAR*
CYP5A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP5A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_1244
49% to 5A1 human
N-terminal revised June 18, 2010
MMALWEFQYIFHNTSGLSVTLGLLLLGLLYW (2)
YSVRPFSVLSRNGIKHPKPLPFFGNLFMFRQ 7316 (0)
7158 GFFNPLNDLIKTHGRVCG 7105 (2)
7021 YYLGRKPVVVVADPEMLRQVMVKDFSSFPNRM 6926 (0)
6848 SLRFITKPMSDCLLMLRNERWKRVRSILTPAFSASKMKE 6732 (0)
6519 MVPLINTATDALIKNLDAFAESAEAFNIHK 6430 (2)
6355 CFGCFTMDVVASVAFGTQVDSQNNCDDPFVRHAQLFFSFNFFRPIMLFF 6209 (1)
6046 AAFPSLAAPLVGIIPNKKRDDMNHFFIRTIQKIIKQREEQPPEQ 5915 (0)
5794 RRRDFLQLMLDARTSDESVSIEHFDTAHPVGEAHNRSEQNQDNQVGPQERPQMKM 5630
5629 ITEDEIVGQAFVFLVAGYETSSNTLAFACYLLAINPECQRELQKEVDHFFTRH 5471 (0)
5395 ESPDYTNVQELKYLDMVISETLRLYPPGFR 5306 (2)
5229 FAREIERDCVVNGQSFPKGATFEIPAGFLHRDPEHWPDPDKFIPER (2)
4998 FTPEAKASRHPFVYIPFGAGPRNCVGMRLAQLEMKMALVRLFRRFNLLACTETK 4837 (0)
4699 VPLELKSSSTLGPKNGVFVKIERRHWDESQVNSPSED* 4586
CYP5A1 Tetraodon nigroviridis (freshwater puffer)
MMAVWDFLNIFHNTSGLSVTLGLLLLGLIYW (2)
YSVYPFSVLSRHGIKHPKPLPFFGNLFMFHQ (0)
LTLFCLTPFSYYLGRKPVVVVADPDMLRQVMVRDFSSFPNRMV (2)
KPMSDCLLMLKNERWKRVRSILTPAFSASKMKE (0)
MVPLINTATDALMKNLDAYAESGEAFNIHK (2)
CFGCFTMDVIASVAFATQVDSQNNTDDPFVRHAQLFFSFSLFRPIALLF (1)
AAFPSIATLLVRIPNKRRDDMNHFFIGTIQKIIQQREEQPPEQ (0)
RRRDFLQLMLDARSSDASVSLEHFDTAEPAGELDTTNEQILNQDRPQRKMITEDEIVGQAFVFLVAGYETSSNTLA FACYLLAINPECQRKLQEEVDHFFTRH (0)
ELPDYTNVQELKYLDMVISETLRLYPPGFR (2)
FARNVERDCVVNGQSFPKGASLEIPAGFLHRDPEHWPDPDKFIPER (2)
FTPEAKASRHPFVYIPFGAGPRNCVGMRLAQLEMKMALVRLFRRFSLVACPETK (0)
VPLELKSSSTLGPKNGVFVKIERRQG*
6A Subfamily
CYP6A1 Musca domestica (house fly)
GenEMBL L27241 (1982bp) L27242 (3888bp)
Cohen,M.B., Koener,J.F. and Feyereisen,R.
Structure and chromosomal localization of CYP6A1, a cytochrome
P450-encoding gene from the house fly.
Gene 146, 267-272 (1994)
Cyp6a2 Drosophila melanogaster (fruit fly)
GenEMBL S51248 (1689bp) M88009 (2848bp)
GenEMBL S36482 S36608 (cross-reference numbers from SwissProt
but they do not match any sequences in Genbank)
Swiss P33270 (507 amino acids) PIR A45378 A47198 (507 amino acids)
Waters,L.C., Zelhof,A.C., Shaw,B.J. and Ch'ang,L.-Y.
Possible involvement of the LTR of transposable element
17.6 in regulating expression of an insecticide resistance
associated P450 gene in Drosophila.
Proc. Natl. Acad. Sci. USA 89, 4855-4859 (1992)
correction: PNAS 89, 12209, (1992)
Note: This is P450-B1, the sister sequence P450-A1 is CYP4G1.
Cyp6a2 Drosophila melanogaster (fruit fly)
GenEMBL U78088(5737bp)
Dunkov, B.C., Guzov, V.M., Mocelin, F., Shotkoski, F., Brun, A.,
Amichot, R., ffrench-Constant, R.H. and Feyereisen,R.
The Drosophila melanogaster gene Cyp6a2: Structure, localization,
heterologous expression and induction by phenobarbital.
submitted (1996)
Cyp6a2 Drosophila melanogaster (fruit fly)
GenEMBL AC007549 comp(100072-101661)
Cyp6a2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6A3 Musca domestica (housefly)
GenEMBL U09231 (2142bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A4 Musca domestica (housefly)
GenEMBL U09232 (2089bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A5v1 Musca domestica (housefly)
GenEMBL U09343 (2110bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A5v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #10-3
7 aa diffs to 6A5v1
CYP6A6 Musca domestica (housefly)
GenEMBL U09344 (718bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6A7 Musca domestica (housefly)
Rene Feyereisen
Submitted to nomenclature committee
Cyp6a8 Drosophila melanogaster
GenEMBL L46859(1595bp) AC020447 comp(122688-124264)
Maitra,S., Dombrowski,S.M., Waters,L.C. and Ganguly,R.
Organization and expression of new cytochrome P450 (Cyp) genes of
Drosophila melanogaster.
Unpublished (1995)
Cyp6a8 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a9 Drosophila melanogaster
GenEMBL L46860(1591bp) AC020447 comp(115043-116610)
Maitra,S., Dombrowski,S.M., Waters,L.C. and Ganguly,R.
Organization and expression of new cytochrome P450 (Cyp) genes of
Drosophila melanogaster.
Unpublished (1995)
CYP6A10 Ceratitis capitata (Mediterranean fruit fly)
GenEMBL U78795(1720bp)
Danielson,P.B., Foster,J.L.M., Cole,S.K. and Fogleman,J.C.
unpublished (1996)
CYP6A11 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD154 PCR of C-terminal
CYP6A12 Ceratitis capitata (Mediterranean fruit fly)
Phil Danielson
Submitted to nomenclature committee
MD47 PCR of C-terminal
Cyp6a13 Drosophila melanogaster
GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, region 44D1-
44D2, DS08616, complete sequence [Drosophila melanogaster]
4-474 comp(7564-8986) 52% identical to CYP6A5
Cyp6a13 Drosophila melanogaster
GenEMBL AC020451 3757-5238 also AC007085 126189-124714 no introns
MLTLLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIY
RKFRGVERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFL
DGPEWRWLRQNLTQVFTSGKMKFMFPNMVEVGEKLTQACRLQVGEIEAKDLCARFTTDVI
GSCAFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVS
EFFLDTVRQTLDYRRRENIHRNDLIQLLMELGEEGVKDALSFEQIAAQALVFFLAGFDTS
STTMSFCLYELALNPDVQERLRVEVLAVLKRNNQKLTYDSVQEMPYLDQVVAETLRKYPI
LPHLLRRSTKEYQIPNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKAR
HPFAYLPFGEGPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQ
EGVHLRMEGLERP
Cyp6a13 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a14 Drosophila melanogaster
GenEMBL AC005457 Drosophila melanogaster, chromosome 2R,
region 44D1-44D2, 2-474 13565-15095 57% identical to CYP6A5
Cyp6a14 Drosophila melanogaster
GenEMBL AC007085 33266-34850
MLFTIALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIY
KKFKGQGPIAGMYTFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTGHLFAL
EGEEWRAMRHKLTPVFTSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLCA
RFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIFTNARLARKLRIK
VLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTL
EQMAAQAFVFFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVL
AQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIHHDPEIY
PEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVS
NRTDVPLIFSKKSFLLTTNDGIYLKVERV
Cyp6a14 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a15p Drosophila melanogaster
GenEMBL AC005457 Drosophila melanogaster, chromosome 2R, region
44D1-44D2, mid to heme comp(10139-9361) POSSIBLE PSEUDOGENE
(MISSING N-TERMINAL)
Cyp6a15p Drosophila melanogaster
GenEMBL AC020451 2595-3373 with in frame stops and frame shifts
AFTVTNSKLAKKLKMKILRDDLTDFFLSVVKPALSGMTLWTSPPSGGRSSRQGGSKFDLS
HNWTLEQMAAQAIVFFLAGFETSSSTMSSCKYELALQPEI*NQIRDEIERVLEGNAITYD
ALAKINYPEQVLSETLRKHPIQLIKFLLETQESFRVRNTELIVEKGTSLLIPVHSVHYDP
HLYPHPKLFDSSRLKAYKSNSRHPFAYLPFGTFGPRSCIGLRFGKMQAKIGIVSLCQRFK
FGDSDLTDIPL
Cyp6a16p Drosophila melanogaster
GenEMBL AC004721 comp(2956-5070)
47% to 6a8
1 exta A nucleotide after MDLLLDLRR causes a frameshift
Cyp6a16 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a17 Drosophila melanogaster
GenEMBL AC020447 109264-110826 complete
AL052842 assembled from fragments only
AL074108 AA699131 AI135898 AI260230 AI258456
AI534145 AI114010 AI533952 AI402220
49% with 6a2
Cyp6a17 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a18 Drosophila melanogaster
GenEMBL AC008285 85740-87319 AI403838
Cyp6a19 Drosophila melanogaster
GenEMBL AC020447 113084-114646
Cyp6a20 Drosophila melanogaster
GenEMBL AC020447 117416-119045
Cyp6a20 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a21 Drosophila melanogaster
GenEMBL AC020447 comp(120585-122149)
Cyp6a21 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a22 Drosophila melanogaster
GenEMBL L46858 AC020447 106987-108653
Ranjan Ganguly
Cyp6a22 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6a23 Drosophila melanogaster
GenEMBL AC020447 111145-112718
Cyp6a23 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6A24 Musca domestica (housefly)
No accession number
Eriko Kamiya
Submitted to nomenclature committee 1/8/2000
62% to CYP6A1
CYP6A25 Musca domestica (housefly)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Feb. 20, 2000
Clone name TA14-1
Cyp6a26 Drosophila simulans
No accession number
Sophie Tares-Amichot
Submitted to nomenclature committee Sept. 29, 2000
96% to Cyp6a2, probable ortholog to 6a2
CYP6A27 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised June 27, 2005 to full length
Clone name Lc_CYP6A8
61% to 6A9 64% to 6A32
CYP6A28 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised June 27, 2005 to full length
Clone name Lc_CYP6A2
52% to 6A9 63% to 6A1 and 6A24
CYP6A29 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A7
50% to 6A9 63% to 6A28 (307 aa)
CYP6A30 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A1
59% to 6A16 (308 aa)
CYP6A31 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A3
60% to 6A14 (355 aa)
CYP6A32 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A4
58% to 6A9 64% to 6A27 (347 aa)
CYP6A33 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A5
51% to 6A16 78% to 6A34 60% to 6A30 (309 aa)
CYP6A34 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A6
49% to 6A16 78% to 6A33 (309 aa)
CYP6A35 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6A9
60% to 6A9 (262 aa)
CYP6A36 Musca domestica (house fly)
No accession number
Nannan Liu
59% identical to 6a21, 61% to 6A27, 58% to 6A37
clone #15
submitted to nomenclature committee 4/10/06
CYP6A37 Musca domestica (house fly)
No accession number
Nannan Liu
66% to 6A9, 67% to 6A7 first 334 aa
clone #15prime
submitted to nomenclature committee 4/10/06
CYP6A38v1 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #17
ONLY 4 AA DIFFS PLUS 2 FRAMESHIFTS TO 6A38v2
98% to AB050019.1 Musca domestica CYP6A24 (7 aa diffs)
12 aa diffs to 6A39
could be an allele of 6A24, or in a gene cluster with 6A genes
CYP6A38v2 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #16-2
ONLY 4 AA DIFFS PLUS 2 FRAMESHIFTS TO 6A38v1
96% (16 aa diffs to 6A39)
could be an allele of 6A24, or in a gene cluster with 6A genes
CYP6A39 Musca domestica (house fly)
No accession number
Nannan Liu
submitted to nomenclature committee 7/20/06
clone #16-8
49% to 6A2, 12 aa diffs to 6A38v1
16 diffs plus two frameshifts to 6A38v2
97% to AB050019.1 13 aa diffs TO 6A24
could be an allele of 6A24, or in a gene cluster with 6A genes
CYP6A40 Musca domestica (housefly) insecticide-susceptible strain TJS
No accession number
Qi Gao
Submitted to nomenclature committee April 2, 2009
top 19 BLAST hits are all CYP6A sequences
52% to Cyp6a9 D. melanogaster
47% to CYP6A1 Musca domestica
47% to Cyp6a2 D. melanogaster
43% to CYP6A3 Musca domestica
44% to CYP6A4 Musca domestica
44% to CYP6A5 Musca domestica
46% to CYP6A6 Musca domestica (partial seq)
49% to CYP6A7 Musca domestica (partial seq)
45% to CYP6A24 Musca domestica
50% to CYP6A25 Musca domestica (partial seq)
49% to CYP6A36 Musca domestica
51% to CYP6A37 Musca domestica
45% to CYP6A38v1 Musca domestica
45% to CYP6A39 Musca domestica
sequence # 1
CYP6A41 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
65% to CYP4A10 Ceratitis capitata (Mediterranean fruit fly)
CYP6A41 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Hu-liming
submitted to nomenclature committee 9/26/2011
99% to CYP6A41 from Jiang Hongbo, 4 amino acid differences
CYP6A42 Lucilia sericata
CYP6A43 Lucilia sericata
CYP6A44 Lucilia sericata
CYP6A45 Lucilia sericata
CYP6A46 Lucilia sericata
CYP6A47 Lucilia sericata
CYP6A48 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
54% to Cyp6a23 D. melanogaster
clone name 926
CYP6A49 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
55% to CYP6A50 Bactrocera dorsalis, 50% to CYP6A28 Lucilia cuprina
top 21 hits are all CYP6A
clone name 1204
CYP6A50 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
53% to Cyp6a9 D. melanogaster, 55% to CYP6A49 Bactrocera dorsalis
top 28 hits are all CYP6A
clone name 1400
CYP6A51 Ceratitis capitata (Mediterranean fruit fly)
No accession number
Rene Feyereisen and Pedro Hernandez
submitted to nomenclature committee Oct. 8, 2012
58% to CYP6A48 Bactrocera dorsalis
6B Subfamily
CYP6B1 Papilio polyxenes (black swallowtail butterfly)
GenEMBL S48952 M80828 (1623bp) M83117 (1608bp)
Swiss Q04552 Q04553 (498 amino acids) PIR A46367 (498 amino acids)
Cohen,M.B., Schuler,M.A. and Berenbaum,M.R.
A host-inducible cytochrome P450 from a host specific
caterpillar: molecular cloning and evolution.
Proc. Natl. Acad. Sci. USA 89, 10920-10924 (1992)
Note: have not been able to download S48952 from GCG or NCBI.
CYP6B1 Papilio polyxenes (black swallowtail butterfly)
GenEMBL Z29624 (3191bp)
Prapaipong,H.H., Berenbaum,M.M. and Schuler,M.M.
Transcriptional regulation of the Papilio polyxenes CYP6B1 gene.
Nuc. Acids Res. 22, 3210-3217 (1994)
CYP6B1v3 Papilio polyxenes (black swallowtail butterfly)
GenEMBL U05037 (3191BP)
Prapaipong,H. Berenbaum,M.R., Schuler,M.A.
Transcriptional regulation of the Papilio polyxenes CYP6B1 gene.
unpublished (1994)
CYP6B1v1/v2Papilio polyxenes (black swallowtail butterfly)
no accession number
Ma, R., Cohen,M.B., Berenbaum,M.R. and Schuler,M.A.
Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that
selectively metabolize linear furanocoumarins.
Arch. Biochem. Biophys. 310, 332-340 (1994)
CYP6B2/CYP6B6 chimera Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U18085 (1995bp)
Wang,X. and Hobbs,A.A.
Isolation and Sequence Analysis of a cDNA clone for a Pyrethroid
Inducible Cytochrome P450 from Helicoverpa armigera.
Unpublished (1995)
Note: this sequence is reported to be a chimera of 6B2 and 6B6
The first 90 aa do not seem to belong to 6B2
Pers. Comm. David G. Heckel
The N-term seq of U18085 is very similar to 6B6, 6B9 and 6B27
With 3-4 amino acid differences.
CYP6B2v1 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ017a-v1Pep
59% to 6B29 96% to 6B2 18 aa diffs in first 90aa
only 2 aa diffs after that. (alternative splicing?)
CYP6B2v2 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ017b-v2Pep
58% to 6B29 2aa diffs to CYP6B2v2
CYP6B2v3 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000107 4 aa diffs to Ha-12E11-C (R. Feyereisen)
in a CYP6B gene cluster
11 aa diffs to CYP6B2v1
The related sequence HAH013651 has 4 aa diffs to HAH000107
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B6v1 Helicoverpa armigera (Australian cotton bollworm)
U64800
Note: this gene cluster has at least 5 genes
CYP6B7, 6B6, 6B2 and two more
There is high polymorphism and the
haplotypes are being examined in more detail
CYP6B6v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_187 99% to 6B6v1 U64800, 4 aa diffs
in a CYP6B gene cluster
The related sequence Contig_271 has 3 aa diffs to Contig_187
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B3 Papilio polyxenes (black swallowtail butterfly)
GenEMBL U25819 (1599bp)
Hung,C.-F., Harrison,T.L., Berenbaum,M.R. and Schuler,M.A.
CYP6B3-A Second Furanocoumarin-inducible Cytochrome P450 Expressed
in Papilio polyxenes
Insect Biochem. and Mol. Biol. (1995) In press
CYP6B3v2 Papilio polyxenes (black swallowtail butterfly)
GenEMBL U65488(2978bp)
Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
Conserved promoter elements in the CYP6B gene family suggest common
ancestry for cytochrome P450 monooxygenases mediating
furanocoumarin detoxification
unpublished (1996)
CYP6B4 Papilio glaucus (butterfly)
GenEMBL U47059(1619bp)
Hung,C.F., Berenbaum,M.R. and Schuler,M.A.
Isolation and characterization of a furanocoumarin-inducible
cytochrome P450 cDNA from a polyphagous lepidopteran.
unpublished (1996)
cDNA slight difference with both genomic sequences
CYP6B4v1 Papilio glaucus (butterfly)
GenEMBL U65490(2957bp)
Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
Conserved promoter elements in the CYP6B gene family suggest common
ancestry for cytochrome P450 monooxygenases mediating
furanocoumarin detoxification.
unpublished (1996)
CYP6B4v2 Papilio glaucus (butterfly)
GenEMBL U65489(4279bp)
Hung,C.F., Holzmacher,R., Connolly,E., Berenbaum,M. and Schuler,M.
Conserved promoter elements in the CYP6B gene family suggest common
ancestry for cytochrome P450 monooxygenases mediating
furanocoumarin detoxification.
unpublished (1996)
CYP6B5 Papilio glaucus (butterfly)
Hung,C.-F. and Schuler,M.
no accession number
genomic DNA missing last 24 amino acids
1 aa difference from B4v2, both B4v2 and B5 on one piece of DNA
submitted to Nomenclature Committee
CYP6B6 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL U64800(1936bp)
Ranasinghe,C. and Hobbs,A.A.
A member of the cytochrome P450 family CYP6B from Helicoverpa
armigera.
unpublished (1996)
CYP6B6 Helicoverpa armigera (Australian cotton bollworm)
Note: this gene cluster has at least 5 genes
CYP6B7, 6B6, 6B2 and two more
There is high polymorphism and the
haplotypes are being examined in more detail
CYP6B7 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL AF031468 (2411bp)
Ranasinghe,C. and Hobbs,A.A.
Complete cDNA sequence for Cytochrome P450 CYP6B7 from Helicoverpa
armigera (Cotton Bollworm)
Unpublished
CYP6B7 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
1 aa diff.
CYP6B8v1 Helicoverpa zea
GemEMBL AF102263
Li,X.C., Berenbaum,M.R. and Schuler,M.A.
Molecular cloning and expression of CYP6B8: a xanthotoxin-inducible
cytochrome P450 cDNA from Helicoverpa zea
Insect Biochem. Mol. Biol. 30, 75-84 2000
submitted to nomenclature committee 10/27/98
99% identical to 6B7 (this is the orthologous gene to 6B7)
CYP6B8v2 Helicoverpa Zea
GenEMBL AF285828
Xianchun Li
Clone name: P6
very similar to 6B8
Submitted to nomenclature committee June 14, 2000
CYP6B8v3 Helicoverpa Zea
GenEMBL AF285829
Xianchun Li
Clone name: P12
very similar to 6B8
Submitted to nomenclature committee June 14, 2000
CYP6B8v4 Helicoverpa Zea
GenEMBL AF285830
Xianchun Li
Clone name: P15
very similar to 6B8
Submitted to nomenclature committee June 14, 2000
CYP6B8v5 Helicoverpa Zea
GenEMBL AF285186
Xianchun Li
Clone name: P23
Intron sequence differs from 6B8 by 229 bp insertion otherwise very
similar to 6B8
Submitted to nomenclature committee June 14, 2000
formerly CYP6B28 but now an allele of CYP6B8
CYP6B8v6 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_208 99% to 6B8v1 (2 aa diffs)
in a CYP6B gene cluster
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B9 Helicoverpa zea
no accession number
Satish Pimprale
submitted to nomenclature committee 10/6/98
most like CYP6B6 (95% identity) 90% with 6B2, 86% with 6B7
and 87% with 6B8
CYP6B10v1 Heliothis virescens (tobacco budworm)
no accession number
Satish Pimprale
submitted to nomenclature committee 10/6/98
most like CYP6B6 (92% identity) 86% with 6B2, 6B7 and 6B8
CYP6B10v2 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
96% to CYP6B10v1 Heliothis virescens
CYP6B11 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F2
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B12 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F47
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B13 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-C1
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B14 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-P46
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B15 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-P47
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B16 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F28
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B17 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
IN-G1
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B18 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F54
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B19 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F17
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B20 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F61
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B21 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-F46
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B22 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-F8
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B23 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-X9
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B24 Papilio glaucus
No accession number
Weimin Li and May Berenbaum
SF-X43
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B25 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-X21
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B26 Papilio canadensis
No accession number
Weimin Li and May Berenbaum
CAN-X22
Note: all 6b11-6b26 sequences are very similar at the protein level
They have been given different gene names because they have insertions/
deletions in their intron and 5 prime flanking regions that suggest they are different genes
CYP6B27 Helicoverpa Zea
GenEMBL AF285831
Xianchun Li
Clone name: 6B6G13R4
Intron sequence differs from 6B9
Submitted to nomenclature committee June 14, 2000
CYP6B28X Helicoverpa Zea
GenEMBL AF285186
Xianchun Li
Clone name: P23
Intron sequence differs from 6B8 by 229 bp insertion otherwise very
similar to 6B8
Submitted to nomenclature committee June 14, 2000
Renamed CYP6B8v5 an allele of CYP6B8
CYP6B29 Bombyx mori (silkworm)
BAAB01105883.1 BAAB01064450.1
51% TO 6B1
See silkworm page for sequence
CYP6B29 Bombyx mori (silkworm)
GenEMBL DQ252324
Wang,D., Xu,Y.X., Wei,Z.G., Zhao,H.Q., Chen,Y.H.,
Li,B., Gong,C.L. and Shen,W.D.
Only 8 differences to 6B29 Bombyx mori genomic seqs
Since one of the genomic diffs is a stop codon
This mRNA seq is probably the more accurate seq
CYP6B29 Bombyx mandarina (wild silkworm)
GenEMBL DQ252325
Wang,D., Xu,Y.X., Wei,Z.G., Zhao,H.Q., Chen,Y.H.,
Li,B., Gong,C.L. and Shen,W.D.
Only 4 differences to 6B29 Bombyx mori genomic seqs
CYP6B30 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
Submitted to nomenclature committee Jan. 13, 2004
94% to CYP6B25
CYP6B31 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee Jan. 27, 2005
74% to 6B2
CYP6B32 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
2 aa diffs to PMC5-8, 3 aa diffs to PMC7-13,
3 aa diffs to PMC5-15, 6 aa diffs to PMC6-15, 7 aa diffs to PMC6-13
91% to 6B30
clone name PMC5-4
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B33 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
1 aa diff to PMC5-15 , 2 aa diffs to PMC5-4, 91% to 6B30
clone name PMC5-8
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B34 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
1 aa diff to PMC5-8, 91% to 6B30
clone name PMC5-15
note: 6B32-6B37 came from a single larvae, so there cannot be six alleles of a
single gene in one larvae. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B35 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
6 aa diffs to PMC7-13, 90% to CYP6B30
clone name PMC6-13
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B36 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
6 aa diffs to PMC5-4, 91% to CYP6B30
clone name PMC6-15
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B37 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
3 aa diffs to PMC5-4, 91% to CYP6B30
clone name PMC7-13
note: 6B32-6B37 came from a single larva, so there cannot be six alleles of a
single gene in one larva. Because we cannot tell allele from gene, we have given
them all separate gene names, though some of them may be alleles.
CYP6B38 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
95% to 6B39, 79% to 6B40, 75% to 6B42,
74% to CYP6B6 Helicoverpa armigera, 73% to CYP6B2v1, 73% to 6B27
CYP6B39 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
95% to 6B38, 79% to 6B40, 76% to 6B42,
74% to CYP6B6 Helicoverpa armigera
CYP6B40 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
79% to 6B38, 79% to 6B39,
74% to CYP6B6 Helicoverpa armigera, 73% to 6B2 Helicoverpa armigera
CYP6B41 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
73% to 6B39, 71% to 6B6
CYP6B42 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
76% to 6B6, 77% to 6B7
CYP6B42 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
93% to CYP6B42 Spodoptera frugiperda (probable ortholog)
CYP6B43.a Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_157 54% to CYP6B2 N-term aa 1-164, might join with Contig_259
HAH005783 is 100% to Contig_157
in a CYP6B gene cluster
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B43.b Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_259 37% to 6B27 aa 174-340 mid region,
HAH005621 is 100% to Contig_259
might join with Contig_157
in a CYP6B gene cluster
The genes in this cluster are complicated by
Polymorphism and sequencing of different haplotypes
and different strains. There is potential for name changes.
CYP6B43 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
90% to CYP6B43.a Helicoverpa armigera
85% to CYP6B43.b Helicoverpa armigera
CYP6B44 Amyelois transitella (Navel orangeworm)
No accession number
Guodong Niu
submitted to nomenclature committee May 27, 2008
clone AL55-2
55% to CYP6B29
CYP6B45 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6B46 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6B47 Spodoptera litura (common cutworm)
No accession number
Jialiang Zhou
submitted to nomenclature committee July 28, 2009
84% to CYP6B39
CYP6B48 Spodoptera litura (common cutworm)
No accession number
Jialiang Zhou
submitted to nomenclature committee July 28, 2009
85% to CYP6B39, 94% to CYP6B47
CYP6B48 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
95% to CYP6B48 Spodoptera litura (probable ortholog)
93% to CYP6B47 Spodoptera litura
CYP6B49 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
94% to CYP6B27 Helicoverpa zea
CYP6B49 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
93% to CYP6B6v2 Helicoverpa armigera
CYP6B50 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
64% to CYP6B43 Heliothis virescens
CYP6B51 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6B52 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6B53 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
6C Subfamily
CYP6C1 Musca domestica (housefly)
GenEMBL U09233 (2310bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
CYP6C2 Musca domestica (housefly)
GenEMBL U09345 (1801bp)
Cohen,M.B. and Feyereisen,R.
A cluster of P450 genes of the CYP6 family in the house fly.
DNA and Cell Biol. 14, 73-82 (1995)
6D Subfamily
CYP6D1 Musca domestica (housefly)
GenEMBL U15168 (1551bp)
Tomita,T. and Scott,J.G.
cDNA and deduced protein sequence of CYP6D1: the putative gene for
a cytochrome P450 responsible for pyrethroid resistance in the
house fly.
Insect Biochem. Molec. Biol. 25, 275-283 (1995)
Liu,N., Tomita,T. and Scott,J.G.
Allele-specific PCR reveals the CYP6D1 is on chromosome 1 in the
house fly, Musca domestica.
Unpublished (1995)
CYP6D1 Musca domestica (housefly)
GenEMBL U22362(1551bp)
Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
Molecular mechanisms involved in increased expression of a
cytochrome P450 responsible for pyrethroid resistance in the
housefly, Musca domestica
Insect Mol. Biol. 4 (3), 135-140 (1995)
CYP6D1 Musca domestica (housefly)
GenEMBL U22366(1548bp)
Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
Molecular mechanisms involved in increased expression of a
cytochrome P450 responsible for pyrethroid resistance in the
housefly, Musca domestica
Insect Mol. Biol. 4 (3), 135-140 (1995)
CYP6D1 Musca domestica (housefly)
GenEMBL U22367(1551bp)
Tomita,T., Liu,N., Smith,F.F., Sridhar,P. and Scott,J.G.
Molecular mechanisms involved in increased expression of a
cytochrome P450 responsible for pyrethroid resistance in the
housefly, Musca domestica
Insect Mol. Biol. 4 (3), 135-140 (1995)
CYP6D1 Musca domestica strain LPR (house fly)
GenEMBL AF064794
Scott,J.G., Liu,N., Wen,Z., Smith,F.F. and Horak,C.E.
House fly cytochrome P450 CYP6D1: 5' flanking sequences and
comparison of two alleles
Unpublished
CYP6D1v1 allele, complete cds.
CYP6D1v2 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee
CYP6D1v3 Musca domestica strain LPR (house fly)
GenEMBL AF064795
Scott,J.G., Liu,N., Wen,Z., Smith,F.F. and Horak,C.E.
House fly cytochrome P450 CYP6D1: 5' flanking sequences and
comparison of two alleles
Unpublished
CYP6D1v3 allele, complete cds.
CYP6D1v4 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee
CYP6D1v5 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee
Cyp6d2 Drosophila melanogaster
Berkeley Drosophila Genome Project P1 clone DS00837 subclone 2a10 (-)
strand
complete genomic sequence, 4 exons
Cyp6d2variant Drosophila melanogaster
Andrew Hobbs
exon 4 48/53 amino acids identical
submitted to Nomenclature Committee
Cyp6d2 Drosophila melanogaster
GenEMBL AC020206 comp(66328-68065) also AC008350
Cyp6d2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6D3v1 Musca domestica (housefly)
Scott,J.
submitted to Nomenclature Committee 10/28/99
79% identical to 6D1
CYP6D3v2 Musca domestica (housefly)
Eriko Kamiya
Submitted to nomenclature committee Sept. 17, 2000
98% identical to CYP6D3v1
Cyp6d4 Drosophila melanogaster
GenEMBL AC017250 37993-39657 also AC008197 AC009846
Cyp6d4 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6d5 Drosophila melanogaster
GenEMBL AC018176 comp(132649-134791)
Cyp6d5 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6D6 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP6D1
62% to 6D2 70% to 6D3 (366 aa)
CYP6D7 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Sequence revised on Dec. 18, 2007
Original Clone name Lc_CYP6D2
New clone name Luce0098H18 (full length)
61% identical to Drosoph. CYP6d5
CYP6D8 Musca domestica (housefly) insecticide-susceptible strain TJS
No accession number
Qi Gao
Submitted to nomenclature committee April 2, 2009
56% to Cyp6d5 D. melanogaster
sequence # 3
CYP6D9 Bactrocera orientalis (oriental fruit fly)
No accession number
Yong Huang
Submitted to nomenclature committee March 16, 2012
60% to CYP6D7 Lucilia cuprina
6E Subfamily
CYP6E1 Culex quinquefasciatus Say (mosquito)
GenEMBL AB001323
Shinji Kasai
Culex-1
CYP6E1 Culex pipiens
6F Subfamily
CYP6F1 Culex quinquefasciatus Say (mosquito)
Shinji Kasai
Culex-2
submitted to Nomenclature Committee
CYP6F1 Culex pipiens
CYP6F2 Aedes aegypti (yellow fever mosquito)
CYP6F3 Aedes aegypti (yellow fever mosquito)
CYP6F4 Culex pipiens
CYP6F5P Culex pipiens
CYP6F6 Culex pipiens
Cyp6g1 Drosophila melanogaster
no accession number
Phil Danielson
Submitted to nomenclature committee 6/13/98
CS39
Cyp6g1 Drosophila melanogaster
GenEMBL AC015208 comp(21239-22935) also AC007440
Cyp6g1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6g2 Drosophila melanogaster
GenEMBL AC015208 19014-20624
Cyp6g2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6G3 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised to full length June 27, 2005
Clone name Lc_CYP6G
60% to 6G1
CYP6G4 Musca domestica (housefly) insecticide-susceptible strain TJS
No accession number
Qi Gao
Submitted to nomenclature committee April 2, 2009
60% to Cyp6g1 D. melanogaster
sequence # 2
CYP6G5a Lucilia sericata (sheep Blowfly)
CYP6G5b Lucilia sericata (sheep Blowfly)
CYP6G6 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
50% to Cyp6g2 D. pseudoobscura, 48% to CYP6G4 Musca domestica
43% to CYP6AQ17 Pogonomyrmex barabatus
clone name 736
CYP6H1 Locusta migratoria migratorioides
GenEMBL AF115777
Jochen Winter, Graeme Bilbe, Hanny Richener, Bernd Sehringer, Hartmut
Kayser
Cloning of a cDNA Encoding a Novel Cytochrome P450 from the Insect
Locusta migratoria: CYP6H1, a Putative Ecdysone 20-Hydroxylase
BBRC 259, 305-310 (1999)
Submitted to nomenclature committee 12/2/98
CYP6J1 Blattella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee 1/20/99
41% identical to 6H1
CYP6J2 Blattella germanica (German cockroach)
No accession number
Ameya D. Gondhalekar and Mike Scharf
submitted to nomenclature committee Nov. 21, 2010
49% to CYP6J1 in the N-terminal only
CYP6K1 Blatella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee 3/9/99
CYP6L1 Blatella germanica (German cockroach)
GenEMBL AF227531
Wen, Z. and Scott, J.G.
Cytochrome P450 CYP6L1 is specifically expressed in the
reproductive tissues of adult male German cockroaches, Blattella
germanica (L.)
Insect Biochem. Molec. Biol. 31: 179-187 (2001)
submitted to nomenclature committee 2/11/99
41% to CYP6H1, 35% to 6J1
CYP6M1 Anopheles gambiae
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene D
CYPm3r7 on chromosome 3
47% identical to CYP6A5
CYP6M1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r7
CYP6M1 Anopheles funestus
No accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
Submitted to nomenclature committee 1/5/05
81% to 6M1v2 probable ortholog, 66% to 6M2
CYP6M1a Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
Tandem duplication with CYP6M1b and CYP6M1c (88-90% identical)
82% to CYP6M1 An. gambiae
CYP6M1b Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
Tandem duplication with CYP6M1a and CYP6M1c (88-90% identical)
79% to CYP6M1 An. gambiae
CYP6M1c Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
Tandem duplication with CYP6M1a and CYP6M1b (88-90% identical)
83% to CYP6M1 An. gambiae
CYP6M2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r9
CYP6M3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r10
CYP6M4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r11
CYP6M4 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
79% to CYP6M4 An. gambiae
CYP6M5 Aedes aegypti (yellow fever mosquito)
CYP6M5v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I1.4
CYP6M5v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I1.1
CYP6M6 Aedes aegypti (yellow fever mosquito)
CYP6M6 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1-1
CYP6M7 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 3, aa 316-440
89% to 6M3, 76% to 6M2
probable ortholog of 6M3
CYP6M8 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 4, aa 317-441
91% to 6M2, 80% to 6M3
probable ortholog of 6M2
CYP6M9 Aedes aegypti (yellow fever mosquito)
CYP6M10 Aedes aegypti (yellow fever mosquito)
CYP6M11 Aedes aegypti (yellow fever mosquito)
CYP6M12 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 6
83% to CYP6M6 Aedes
CYP6M12 Culex pipiens
CYP6M13 Culex pipiens
CYP6M14 Culex pipiens
CYP6M15 Culex pipiens
CYP6M16 Culex pipiens
CYP6N1 Anopheles gambiae
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 12D2
46% identical to CYP6E1
CYP6N1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r8
CYP6N1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
82% to CYP6N1 An. gambiae
CYP6N2 Anopheles gambiae (formerly CYP6Q1)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene A
46% identical to CYP6A1 and 6E1 52% to 6N1
renamed CYP6N2 based on close sequence similarity to 6N3 and 6N4 sequences
CYP6N2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r4
CYP6N2 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 4
89% identical to CYP6N2 Anopheles gambiae probable ortholog
CYP6N2 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
92% to CYP6N2 An. gambiae
CYP6N3v1 Aedes albopictus
GenEMBL AF283836 (still confidential on July 31 2000)
Zhou Guo-li
62% identical to CYP6N1 over the full length sequence
submitted to nomenclature committee July 31, 2000
CYP6N3v2 Aedes albopictus
GenEMBL AF283837 (still confidential on July 31 2000)
Zhou Guo-li
3 diffs with CYP6N3v1 over the full length sequence
submitted to nomenclature committee July 31, 2000
CYP6N3v3 Aedes albopictus
GenEMBL AF283838 (still confidential on July 31 2000)
Zhou Guo-li
4 diffs with CYP6N3v1 over the full length sequence
submitted to nomenclature committee July 31, 2000
CYP6N3v4 Aedes albopictus
GenEMBL AF284783 (still confidential on July 31 2000)
Zhou Guo-li
2 diffs with CYP6N3v1 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v1 Aedes albopictus
GenEMBL AF284782 (still confidential on July 31 2000)
Zhou Guo-li
83% to CYP6N3v1 over partial sequence (missing heme-end)
60% to 6N1 and 60% to 6N2
submitted to nomenclature committee July 31, 2000
CYP6N4v2 Aedes albopictus
GenEMBL AF284784 (still confidential on July 31 2000)
Zhou Guo-li
3 diffs with CYP6N4v1 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v3 Aedes albopictus
GenEMBL AF284785 (still confidential on July 31 2000)
Zhou Guo-li
1 diff with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v4 Aedes albopictus
GenEMBL AF284786 (still confidential on July 31 2000)
Zhou Guo-li
5 diffs with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v5 Aedes albopictus
GenEMBL AF284787 (still confidential on July 31 2000)
Zhou Guo-li
4 diffs with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N4v6 Aedes albopictus
GenEMBL AF284788 (still confidential on July 31 2000)
Zhou Guo-li
6 diffs with CYP6N4v2 over partial sequence
submitted to nomenclature committee July 31, 2000
CYP6N5X Aedes aegypti (yellow fever mosquito)
Note: 6N5 is the same seq as CYP6N1
CYP6N6 Aedes aegypti (yellow fever mosquito)
CYP6N6v1 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1.4
CYP6N6v2 Aedes aegypti (mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I2.2
CYP6N7 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427077.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 14
66% to CYP6N4v6, 65% to CYP6N3v1
partial seq, 84 aa EXXR to heme
CYP6N8 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427073.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone1-5
61% to CYP6N7
partial seq, 84 aa EXXR to heme
CYP6N9 Aedes aegypti (yellow fever mosquito)
CYP6N10P Aedes aegypti (yellow fever mosquito)
CYP6N11 Aedes aegypti (yellow fever mosquito)
CYP6N12 Aedes aegypti (yellow fever mosquito)
CYP6N13 Aedes aegypti (yellow fever mosquito)
CYP6N14 Aedes aegypti (yellow fever mosquito)
CYP6N15 Aedes aegypti (yellow fever mosquito)
CYP6N16 Aedes aegypti (yellow fever mosquito)
CYP6N17 Aedes aegypti (yellow fever mosquito)
CYP6N18 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 33
75% to 6N16 Aedes, 74% to 6N2 Anoph.
CYP6N18 Culex pipiens
CYP6N19 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 31
68% to 6N11 Aedes, 57% to 6N1v2 Anoph.
CYP6N19 Culex pipiens
CYP6N20 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 28
55% to 6N1v2 Anoph., 67% to 6N9 Aedes
CYP6N20v1 Culex pipiens
CYP6N20v2 Culex pipiens
CYP6N21P Culex pipiens
CYP6N22 Culex pipiens
CYP6N23 Culex pipiens
CYP6N24 Culex pipiens
CYP6N25 Culex pipiens
CYP6N26P Culex pipiens
CYP6N27P Culex pipiens
CYP6P1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 7G05
44% identical to CYP6A5
CYP6P1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r7
CYP6P1 Anopheles funestus
No accession number
Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson,
Lizette Koekemoer, on Sept. 9, 2004
82% identical to A. gambiae CYP6P1 I-helix to heme
this is the presumed ortholog to CYP6P1
other 6P sequences are much less similar
CYP6P1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
81% to CYP6P1 An. gambiae,
88% to CYP6P8 An. minimus probable ortholog
CYP6P2 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/31/02
clone name P2
61% identical to CYP6P1
CYP6P2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r8
CYP6P2 Anopheles funestus
No accession number
Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson,
Lizette Koekemoer, on Sept. 9, 2004
84% identical to A. gambiae CYP6P2 I-helix to heme
this is the presumed ortholog to CYP6P2 A. gambiae
other 6P sequences are much less similar
CYP6P2 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
82% to CYP6P1 An. gambiae,
89% to CYP6P7 An. minimus probable ortholog
CYP6P3 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/31/02
clone name 17d17
55% identical to CYP6P1
CYP6P3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r4
CYP6P4 Anopheles gambiae (mosquito)
no accession number
Dimitra Nikou
submitted to nomenclature committee 2/25/02
clone name 18M16
64% to 6P3 missing C-term
CYP6P4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r6
CYP6P4 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 3, 126 aa fragment
89% identical to CYP6P4 Anopheles gambiae probable ortholog
1 aa diff to CYP6P4b Anopheles funestus
4 aa diffs to CYP6P4a Anopheles funestus
CYP6P4a Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
85% to CYP6P1 An. gambiae
CYP6P4a and CYP6P4b are tandem duplicates 95% identical
CYP6P4b Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
85% to CYP6P1 An. gambiae
CYP6P4a and CYP6P4b are tandem duplicates 95% identical
CYP6P5 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
77% to 6P3
CYP6P5 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r5
CYP6P5 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 2
88% identical to CYP6P5 Anopheles gambiae probable ortholog
CYP6P5 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
90% to CYP6P5 An. gambiae (complete seq)
CYP6P6 Anopheles minimus
GenEMBL AY128947
This sequence was named incorrectly by the author as CYP6P5
but that was not an official name, so it has been changed.
84% to CYP6P3
CYP6P7 Anopheles minimus
No accession number
Rongnoparut, P.
Submitted to nomenclature committee October 17, 2003
Clone name minimus 1
81% to CYP6P2
note this is the ortholog of CYP6P2 An. Gambiae and An. Funestus
It may be best to rename this seq CYP6P2 to indicate that.
CYP6P8 Anopheles minimus
No accession number
Rongnoparut, P.
Submitted to nomenclature committee October 17, 2003
Clone name minimus 2
79% to CYP6P1
CYP6P9a Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
Tandem duplication with CYP6P9bv1 (94% identical)
95% to CYP6P9bv3 Anopheles funestus
93% to CYP6P9bv2 (old CYP6P13) Anopheles funestus
89% to CYP6P6 An. minimus probable co-ortholog
CYP6P9bv1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
98% to CYP6P9bv2 (old CYP6P13) Anopheles funestus
97% to CYP6P9bv3 Anopheles funestus
94% to CYP6P9a Anopheles funestus (adjacent gene)
92% to CYP6P6 An. minimus probable co-ortholog
CYP6P9bv2 Anopheles funestus
Formerly CYP6P13
No accession number
Tonderayi Matambo, Lizette Koekemoer
submitted to nomenclature committee 12/13/07
complete seq
98% to CYP6P9bv1 Anopheles funestus
97% to CYP6P9bv3 Anopheles funestus EU852650
93% to CYP6P9a full seq., 90% to 6P6
name changed from CYP6P13 to CYP6P9bv2
CYP6P9bv3 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 1, aa 327-451 (only 125 aa long)
86% to 6P3, 83% to 6P5
note: there are two 6P9 genes 94% identical by tandem duplication
This seq is CYP6P9bv3 and the other is CYP6P9a
These are co-orthologs to An. gambiae CYP6P3 and An. minimus CYP6P6
CYP6P9bv3 Anopheles funestus
EU852650
Tonderayi Matambo, Lizette Koekemoer
submitted to nomenclature committee 12/13/07
nearly complete seq, one aa diff to partial seq of 125 aa
97% to to CYP6P9bv1 Anopheles funestus
97% to to CYP6P9bv2 (old CYP6P13) Anopheles funestus
95% to CYP6P9a Anopheles funestus
84% to 6P3
CYP6P10v1 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948075
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 1
65% to CYP6P4
CYP6P10v2 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948076
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 2
98.6% to CYP6P10v1
CYP6P10v3 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948077
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 3
98.4% to CYP6P10v2
CYP6P10v4 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948078
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 5
99% to CYP6P10v3
CYP6P10v5 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY948079
Shaoming Huang
Submitted to nomenclature committee Feb. 21, 2005
Clone name sample 6
99% to CYP6P10v4
CYP6P10v6 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427074.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 9
77% to CYP6P4, 1aa diff to CYP6P10v5
partial seq, 84 aa EXXR to heme
CYP6P10v7 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427078.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 17
1aa diff to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P10v8 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427079.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 18
3aa diffs to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P10v9 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427080.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 19
3aa diffs to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P10v10 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427081.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 21
1aa diff to CYP6P10v6
partial seq, 84 aa EXXR to heme
CYP6P11 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427084.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 26
66% to CYP6P3, 63% to 6P6
partial seq, 84 aa EXXR to heme
CYP6P12v1 Aedes aegypti (yellow fever mosquito)
CYP6P12v2 Aedes aegypti (yellow fever mosquito)
CYP6P13X Anopheles funestus
No accession number
Tonderayi Matambo, Lizette Koekemoer
submitted to nomenclature committee 12/13/07
complete seq
93% to CYP6P9a full seq., 90% to 6P6
name changed to CYP6P9bv2
CYP6P14 Culex pipiens
CYP6P15P Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
between CYP6AA2 and CYP6P9a
the most conserved region (before the PERF motif)
is 70% to CYP6P2 so this is probably a CYP6P pseudogene
CYP6P16 Anopheles sinensis
No accession number
Yanfei
Submitted to nomenclature committee 7/4/2013
80% to CYP6P5 A. funestus
78% to CYP6P5 A. gambiae
76% to CYP6P9bv1 A. funestus
CYP6Q1X Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene A
46% identical to CYP6A1 and 6E1 52% to 6N1
renamed CYP6N2 based on close sequence similarity to 6N3 and 6N4 sequences
CYP6R1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene B
43% identical to CYP6Q1
CYP6R1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r3
CYP6R1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
68% to CYP6R1 An. gambiae
CYP6S1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 8/9/99
clone name 04I gene C
45% identical to CYP6A1
CYP6S1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r2
CYP6S1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
83% to CYP6S1 An. gambiae
CYP6S2 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 10/15/2001
clone name 24H06
72% identical to CYP6S1
CYP6S2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r1
CYP6S2 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
82% to CYP6S2 An. gambiae
CYP6S3 Aedes aegypti (yellow fever mosquito)
CYP6S4 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 27
77% to 6S3 Aedes, 66% to 6S1 Anopheles
CYP6S4 Culex pipiens
Cyp6t1 Drosophila melanogaster
GenEMBL AC012831 comp(42975-44564) no introns
Cyp6t1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6t2p Drosophila melanogaster
GenEMBL AC014742 1042-2504
Cyp6t3 Drosophila melanogaster
GenEMBL AC015208 comp(17123-18689)
Cyp6t3 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6u1 Drosophila melanogaster
GenEMBL AC017706 15959-17471 also AC008288
Cyp6u1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6v1 Drosophila melanogaster
GenEMBL AC011761 comp(54926-57766) also AC015002
Cyp6v1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp6w1 Drosophila melanogaster
GenEMBL AC014226 comp(15025-16689) also AC008257
Cyp6w1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP6X1v1 Lygus lineolaris (Heteroptera: Miridae) Lygus bug
GenEMBL AY054411.1|
Yu Cheng Zhu
Submitted to nomenclature committee 8/17/01
CYP42% to CYP6N sequences, 41% to CYP6S, 40% to CYP6P sequences
40% to some CYP6A sequences, 40% to CYP6F
Pyrethroid susceptible strain
CYP6X1v2 Lygus lineolaris (Heteroptera: Miridae) Lygus bug
GenEMBL AY054412.1|
Yu Cheng Zhu
Submitted to nomenclature committee 8/17/01
CYP42% to CYP6N sequences, 41% to CYP6S, 40% to CYP6P sequences
40% to some CYP6A sequences, 40% to CYP6F
Pyrethroid resistant strain (0ne amino acid difference to 6X1v1)
CYP6X1v3 Lygus lineolaris (Heteroptera: Miridae) Lygus bug
GenEMBL AY125086
Yu Cheng Zhu
Submitted to nomenclature committee 6/17/02
Clone name LRR118 99% to 6X1 v1 (2 aa differences)
Note: clone names were reversed. Corrected on 2/9/2010
CYP6X1v4 Lygus lineolaris (Heteroptera: Miridae) Lygus bug
No accession number
Yu Cheng Zhu
Submitted to nomenclature committee 6/17/02
Clone name LRR117 98% to 6X1v1 (6 aa differences)
Note: clone names were reversed. Corrected on 2/9/2010
CYP6Y1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/21/02
clone name M1b
45% identical to CYP6M1
CYP6Y1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r6
CYP6Y1 Anopheles funestus (mosquito)
no accession number
John Morgan, Hilary Ranson, Ashley Vaughan, Dolphine Amenya,
Lizette Koekemoer
submitted to nomenclature committee 11/17/04
submitted name sequence 1
85% identical to CYP6Y1 Anopheles gambiae probable ortholog
CYP6Y1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
85% to CYP6Y1 An. gambiae
CYP6Y2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r5
CYP6Y2 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
88% to CYP6Y2 An. gambiae
CYP6Y3 Aedes aegypti (yellow fever mosquito)
CYP6Y4 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 29
57% to 6Y3 Aedes, 64% to 6Y2 Anoph.
CYP6Y4 Culex pipiens
CYP6Y5 Culex pipiens
CYP6Y6 Culex pipiens
CYP6Z1 Anopheles gambiae (mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/21/02
clone name 18L09
40% identical to CYP6F1 41% to CYP6D3v2
CYP6Z1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r14
CYP6Z1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
85% to CYP6Z1 An. gambiae
CYP6Z2 Anopheles gambiae (mosquito)
no accession number
Dimitra Nikou
submitted to nomenclature committee 2/25/02
clone name 18LB
69% to CYP6Z1
CYP6Z2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r13
CYP6Z3 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
40% to 6d5 70% to 6Z1 67% to 6Z2
CYP6Z3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r10
CYP6Z3 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
85% to CYP6Z3 An. gambiae
CYP6Z4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPm3r12
CYP6Z5v1 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427067.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
CloneE1
64% to CYP6Z2, 3aa diffs to CYP6Z5v4
partial seq, 130 aa at C-term
CYP6Z5v2 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427068.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
CloneE2
1aa diff to CYP6Z5v4
partial seq, 130 aa at C-term
CYP6Z5v3 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427069.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
CloneE3
4aa diffs to CYP6Z5v4
partial seq, 130 aa at C-term
CYP6Z5v4 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427070.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
CloneE4
64% to CYP6Z2
partial seq, 130 aa at C-term
CYP6Z5v5 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427071.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
CloneE5
2aa diffs to CYP6Z5v4
partial seq, 130 aa at C-term
CYP6Z5v6 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427075.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 10
3aa diffs to CYP6Z5v1
partial seq, 83 aa EXXR to heme
CYP6Z5v7 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427075.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 24
2aa diffs to CYP6Z5v1
partial seq, 83 aa EXXR to heme
CYP6Z6 Aedes aegypti (yellow fever mosquito)
CYP6Z7 Aedes aegypti (yellow fever mosquito)
CYP6Z8 Aedes aegypti (yellow fever mosquito)
CYP6Z9 Aedes aegypti (yellow fever mosquito)
CYP6Z10 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 5
58% to CYP6Z4 Anopheles gambiae
CYP6Z10 Culex pipiens
CYP6Z11 Culex pipiens
CYP6Z12 Culex pipiens
CYP6Z13P Culex pipiens
CYP6Z14 Culex pipiens
CYP6Z15 Culex pipiens
CYP6Z16 Culex pipiens
CYP6Z17 Culex pipiens
CYP6AA1 Anopheles gambiae (mosquito)
no accession number
Dimitra Nikou
submitted to nomenclature committee 2/25/02
clone name 29006
45% to 6P1 44% to 6A2 missing about 25aa at C-term
CYP6AA1 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
47% to 6A2 100% to 6AA1
CYP6AA1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r1
CYP6AA1 Anopheles minimus
GenEMBL AY129952
This sequence was named incorrectly by the author as CYP6AA2
but that was not an official name, so it has been changed.
85% to CYP6AA1
name changed from CYP6AA3
note: recent work has shown this seq is the ortholog of CYP6AA1
We are renaming the sequence to CYP6AA1 for this reason.
CYP6AA1 Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 2, aa 323-447
84% to 6AA1, 68% to 6AA2
probable ortholog of 6AA1
name changed from CYP6AA4
note: recent work has shown this seq is the ortholog of CYP6AA1
We are renaming the sequence to CYP6AA1 for this reason.
CYP6AA2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r2
CYP6AA2 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
80% to CYP6AA2 A. gambiae
CYP6AA3X Anopheles minimus
GenEMBL AY129952
This sequence was named incorrectly by the author as CYP6AA2
but that was not an official name, so it has been changed.
85% to CYP6AA1
note: recent work has shown this seq is the ortholog of CYP6AA1
We are renaming the sequence to CYP6AA1 for this reason.
CYP6AA4X Anopheles funestus
No accession number
Lizette Koekemoer
submitted to nomenclature committee 6/14/04
CYP6 Contig 2, aa 323-447
84% to 6AA1, 68% to 6AA2
probable ortholog of 6AA1
note: recent work has shown this seq is the ortholog of CYP6AA1
We are renaming the sequence to CYP6AA1 for this reason.
CYP6AA5v1 Aedes aegypti (yellow fever mosquito)
CYP6AA5v2 Aedes aegypti (yellow fever mosquito)
CYP6AA6 Aedes aegypti (yellow fever mosquito)
CYP6AA7 Culex pipiens
CYP6AA8 Culex pipiens
CYP6AA9 Culex pipiens
CYP6AB1 Trichoplusia ni Family: Noctuidae (caterpillar)
No accession number
Ping Wang
38% to 6F1 39% to 6a2 (sequence 1)
submitted to nomenclature committee 5/20/02
54% to 6AB2 58% to 6AB3
CYP6AB2 Trichoplusia ni Family: Noctuidae (caterpillar)
No accession number
Ping Wang
38% to 6B9, 38% to 6a2 (sequence 4)
submitted to nomenclature committee 5/20/02
formerly 6AC1 renamed CYP6AB2 54% identical to 6AB1 56% to 6AB3
CYP6AB3v1 Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
AY295773.1
Weimin Li and May Berenbaum
submitted to nomenclature committee 10/15/02
58% to 6AB1, 56% to 6AB2
clone name heme1
CYP6AB3v2 Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
EF111024.1
CYP6AB4 Bombyx mori (silkworm)
BAAB01081811.1 BAAB01162324.1 BAAB01031011.1
EF017798 (4 aa diffs to BAAB accessions), EF415299
64% TO 6AB1
See silkworm page for sequence
CYP6AB4 Bombyx mandarina
DQ993198
8 aa diffs to CYP6AB4 Bombyx mori
CYP6AB5 Bombyx mori (silkworm)
BAAB01021567.1 BAAB01206787.1
56% TO 6AB4
See silkworm page for sequence
CYP6AB5 Bombyx mandarina
FJ795021
95% to CYP6AB5 B. mori
CYP6AB6 Papilio multicaudatus
No accession number
Wenfu Mao and May Berenbaum
submitted to nomenclature committee 11/1/05
62% to 6AB4
CYP6AB7 Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
EF111023.1
Wenfu Mao and May Berenbaum
submitted to nomenclature committee 12/28/05
88% to 6AB3, 57% to 6AB1
clone name C-1
CYP6AB8 Bombyx mori (silkworm)
AADK01010774.1
See silkworm page for details
CYP6AB9 Helicoverpa armigera (cotton bollworm)
JN176570 (3 aa diffs)
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_217 64% to CYP6AB4 Bombyx
Contig_161 has 1 aa diff to Contig_217
CYP6AB10.a Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_164 N-terminal half
87% to CYP6AB2, 53% to CYP6AB9, 50% to CYP6AN1
HAH006987_2 is 100% to Contig_164
CYP6AB10.b Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_196 C-terminal half
opp end of 6AB10.a? Whole seq is 54% to CYP6AB9
Contig_195 has 4 aa diffs to Contig_196
85% to CYP6AB2, 54% to 6AB9, 56% to 6AN1
CYP6AB11 Amyelois transitella (Navel orangeworm)
No accession number
Guodong Niu
submitted to nomenclature committee May 22, 2008
65% to CYP6AB4
CYP6AB12 Spodoptera frugiperda (a moth)
KC789747
Rene Feyereisen
Submitted to nomenclature committee Nov. 21, 2008
60% to CYP6AB1 Trichoplusia ni,
75% to CYP6AB9 Helicoverpa armigera
CYP6AB13 Manduca sexta
GU731534
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6AB14 Spodoptera litura
JF829002
Zihbin Xu, Sichun Zheng, Qili Feng
submitted to nomenclature committee April 17, 2011
70% to CYP6AB4 Bombyx mori
CYP6AB14 Spodoptera littoralis (cotton leafworm)
JX310081
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
98% to CYP6AB14 Spodoptera litura (probable ortholog)
CYP6AB15 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
61% to CYP6AB7 Depressaria pastinacella
CYP6AB16 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
63% to CYP6AB13 Manduca sexta
CYP6AB17 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
66% to CYP6AB13 Manduca sexta
CYP6AB18 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
54% to CYP6AB7 Depressaria pastinacella
CYP6AB19v1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
89% to CYP6AB9 Helicoverpa armigera
CYP6AB19v2 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
99% to CYP6AB19v1 Heliothis subflexa
CYP6AB19 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
98% to CYP6AB19v2 Heliothis subflexa
CYP6AB20 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
CYP6AB20 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
98% to CYP6AB20 Heliothis subflexa
CYP6AB21 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
85% to CYP6AB2 Trichoplusia ni
CYP6AB21 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
97% to CYP6AB21 Heliothis subflexa
CYP6AB22 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
79% to CYP6AB14 Spodoptera litura
CYP6AB23 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
84% to CYP6AB19v1 Heliothis subflexa
CYP6AB24 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
95% to CYP6AB17 Heliconius melpomene
CYP6AB25 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
69% to CYP6AB14 Spodoptera litura
CYP6AB26 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
65% to CYP6AB14 Spodoptera litura
CYP6AB27 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
56% to CYP6AB14 Spodoptera litura
CYP6AB28 Plutella xylostella
Gene number CCG004643.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
61% TO CYP6AB7 Depressaria pastinacella
MISSING 4 AA AT HEME SIGNATURE
CYP6AB29 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 14, 2012
90% to CYP6AB15 Heliconius melpomene
CYP6AB30 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 14, 2012
82% to CYP6AB27 Heliconius melpomene
CYP6AB31 Spodoptera littoralis (cotton leafworm)
JX310080
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
81% to CYP6AB23 Heliothis virescens
CYP6AB32 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AB33 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AB34 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AB35 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AB36 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AB37 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AB38 Helicoverpa armigera (cotton bollworm)
CYP6AB39 Amyelois transitella (Navel orangeworm)
CYP6AB40 Amyelois transitella (Navel orangeworm)
CYP6AB41 Amyelois transitella (Navel orangeworm)
CYP6AB42 Amyelois transitella (Navel orangeworm)
CYP6AB43 Amyelois transitella (Navel orangeworm)
CYP6AB44 Amyelois transitella (Navel orangeworm)
CYP6AB45 Chilo suppressalis (striped rice stem borer)
CYP6AB46 Chilo suppressalis (striped rice stem borer)
CYP6AB47 Chilo suppressalis (striped rice stem borer)
CYP6AB48 Chilo suppressalis (striped rice stem borer)
CYP6AB49 Chilo suppressalis (striped rice stem borer)
CYP6AB50 Chilo suppressalis (striped rice stem borer)
CYP6AB51 Chilo suppressalis (striped rice stem borer)
CYP6AB52 Chilo suppressalis (striped rice stem borer)
CYP6AB53 Chilo suppressalis (striped rice stem borer)
CYP6AB54 Manduca sexta (tobacco hornworm)
CYP6AB55 Agrotis ipsilon
JQ901386
85% to CYP6AB10
CYP6AB56 Mamestra brassicae
JQ901385
88% to CYP6AB2
CYP6AC1X Trichoplusia ni Family: Noctuidae (caterpillar) name discontinued
No accession number
Ping Wang
38% to 6B9, 38% to 6a2 (sequence 4)
submitted to nomenclature committee 5/20/02
renamed CYP6AB2 54% identical to 6AB1 56% to 6AB3
CYP6AD1 Anopheles gambiae (malaria mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
42% to 6P1
CYP6AD1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPf2r9
CYP6AD1 Anopheles funestus
No accession number
Charles Wondji
submitted to nomenclature committee 6/25/12
80% to CYP6AD1 A. gambiae
CYP6AE1 Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
No accession number
Weimin Li and May Berenbaum
submitted to nomenclature committee 10/15/02
38% to 6AB2
clone name C4-31
CYP6AE2 Bombyx mori (silkworm)
No accession number
Junwen Ai
submitted to nomenclature committee Jan. 31, 2007
nearly identical to sequence CYP6AEcc on Bombyx page except
one region from amino acids 106-256 does not match.
The EST BY914225 agrees with this sequence so the CYP6AEcc sequence
appears to be a hybrid assembled from two genes.
CYP6AE3P Bombyx mori (silkworm)
Matches CYP6AEbb except for a short middle region
This part of 6AEbb matches 6AE2
96% to CYP6AE2
See silkworm page for sequences
CYP6AE4 Bombyx mori (silkworm)
Matches CYP6AEaa
See silkworm page for sequences
CYP6AE5 Bombyx mori (silkworm)
Matches CYP6AEff
See silkworm page for sequences
CYP6AE6P Bombyx mori (silkworm)
Matches CYP6AEee
See silkworm page for sequences
CYP6AE7 Bombyx mori (silkworm)
Matches CYP6AEdd
See silkworm page for sequences
CYP6AE7 Bombyx mori strain Laos
GenEMBL EF432656
Dong Wang
submitted to nomenclature committee Oct. 2, 2007
MILTIIFILSLCVYILYRISTRKFDYWQKKNVSYVEPAPFLGNY
SGYILLKENLLDVVHNLSKLFPNDPYVGAFFGTKPTLIVKDPEFIKLVLIKDFYYFHG
REGSKYTHNEVITQGIFFTYGDRWKVIRQNLTPLFSSSKIRNMFRTIEKCSGVFENLL
DEESLAPEVEMRSVMSRFTMDCIGGCAFGVDTNAMQEPKDNIFKTMGYLFFESTTRRG
IKNVFKAIWPEIFYGLGFKVFPTDLNEFFSKLLVGIFEARDYKPSSQNVFINLLLNLK
KNRHIVGDRLLKIKTGNVRAESKIKLEVDDELLVSQCVAFFIAGFETSSTISRFTLYE
LAKNPDVQKRAQKEVDEYIKKHNNKLDYDCVKELPFVEACIDEALRLYPVLGVLTREV
MEQYTFPTGLTLDKGDRVHIPVYHLHRDPEYFPEPELFKPERFCGEEKRNIRPFTYLP
FGAGPRTCIGQRFAKMQMLAGLVTILKRYTVCLAEGMPETINFEQRAIVTQPNIGIRL
NLLPRNN
CYP6AE8X Bombyx mori (silkworm)
Matches CYP6AEgg
See silkworm page for sequence
Note: this sequence has had a name change from CYP6AE8 to CYP6AE9v2
CYP6AE8 Bombyx mori strain Laos
GenEMBL EF528486
Dong Wang
submitted to nomenclature committee Oct. 2, 2007
MSVSAVVFAAFVLLVTYIYYWSTRKFDYWKRKNVPYAKPVPFFG
NYMRYITLQSYIGDVTQKLCQQFPDRPYFGSFYGTEPALVLQNPEIIKQVFTKDFYYF
NSRENSDYNHKEIVTQNLFFANGDKWKVVRQNLTPLFSSLKMKNMFYLVEKCNHSLED
MLDKEIKDLQIIEIRSAMIRYTLDSICSSAFGIESNTLSEGGENSPFANMGSIVFSSS
ITRGLKWISRSMWPGIFYKLGLQCFPAEIDGFFERVLTEVFENRGYKPTNRNDFVDLI
LSLKQNDYLTGDGLVPKNMDAKKVTVKVDDALLIAQCVVFFGAGFETSASTLSAALYE
PAKNPEAQRRAQEEVDELLLKHNNKLNYDCLAELPYLEACMNEAMRLYPVLPNITREA
VADYTFPDGLRIEKGMRVHVPVYAIHRNPDNFPDPEEFRPERHLGDAKNDIKQFTFFP
FGEGPRICIGMRFGKMQTIAGMVTCLKKYNFELADGMSKTVPFRSTTVLTQPSTGLFL
KATPRDGWKQRIFAR
CYP6AE9X Bombyx mori (silkworm)
Matches Cyp6AEhh
See silkworm page for sequences
Note: this sequence has had a name change from CYP6AE9 to CYP6AE22v2
CYP6AE9v1 Bombyx mori strain Laos
GenEMBL EF535809
Dong Wang
submitted to nomenclature committee Oct. 2, 2007
MFLLINICVILFVIYYLVTKKYSYWRNRNVSHEKPVLLLGNYGD
LILQKKNFGEMARAICQKFPGEPVVGAFFGTEPVLIPQDPEVIKTILTKDFYYFNGRE
ISEHVHKELLSYNLFATYRDEWKILRQNLTPIFSTAKLKSMFTLIEKCSKSFQNLLED
ETKISKELEVRTLMQRFTIECIGSCIFGVDTDTLGNDKMNPFKAAGSQLSDFSRLVFV
KGIVRAIWPTLFYALGFKTFTTELDIFKKLVNAVFAQRKHKPTTRNDFVDLILTWKNN
NTITGDSIGSFKNSDKTKFSIDVNDDLLLAQCLVFFAAGFETSAMTSSYTLHELAKNQ
RALKKACDEVDAYLLRHGNKINYDCVTELPYLEACIEETLRLYPVLGIITREVMEDYV
LLDKIHLKKGDRIHVPVFHLHHNPEHFPNPEEYRPERFYGEEKRKVKPYTYLPFGEGP
RICIGMRFAKMQSIAGLITILKKFRLELPEGAPTKIEFKPEAFVTTPKDLIKIKFLER
EGWQQRVFV
CYP6AE9v2 Bombyx mori (silkworm)
Matches CYP6AEgg
See silkworm page for sequence
Note: this sequence has had a name change from CYP6AE8 to CYP6AE9v2
CYP6AE10 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee July 26, 2004
56% to 6AE1
CYP6AE11 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
100% identical to Heckels seq.
CYP6AE11 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ018a-v1Pep
58% to 6AE1 66% to 6AE10
CYP6AE11 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH003743 100% to CYP6AE11
Contig_207 has 4 aa diffs to HAH003743
CYP6AE12v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
98% (9 aa diffs) to 6AE12v2
CYP6AE12v1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_150 100% to CYP6AE12v1 from Rene Feyereisen
CYP6AE12v2 Helicoverpa armigera (cotton bollworm)
GenEMBL DQ256407
Yidong Wu and Lina Yue
submitted to nomenclature committee Aug. 13, 2005
clone name YS-6a
67% to CYP6AE11
CYP6AE13 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee Dec. 10, 2005
Clone name sequence 3 NR3 fragment (C-terminal)
63% to 6AE12
CYP6AE14 Helicoverpa armigera (cotton bollworm)
No accession number
Ying-Bo Mao
Submitted to nomenclature committee Sept. 15, 2006
Clone name GIP (Gossypol Inducible P450)
90% to CYP6AE11
CYP6AE14 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_206, 2 aa diffs to CYP6AE14 from Ying-Bo Mao
90% to contig _207 (6AE11)
CYP6AE15v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
74% to CYP6AE12
CYP6AE15v1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH002367 has 4 aa diffs to Contig_184 CYP6AE15v2
100% to CYP6AE15v1 from Rene Feyereisen
CYP6AE15v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_184 4 aa diffs to CYP6AE15v1
CYP6AE16 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
83% to CYP6AE11
CYP6AE17 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
73% to CYP6AE11
CYP6AE17 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_175 has 3 aa diffs to CYP6AE17 from Rene Feyereisen
HAH001433 is 100% to Contig_175
Contig_223 has 4 aa diffs to Contig_175
CYP6AE18 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
72% to CYP6AE11
CYP6AE19 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
56% to CYP6AE11
CYP6AE19 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_224 100% to CYP6AE19 from Rene Feyereisen
89% to Contig_160 CYP6AE20v2, 90% to HAH000205 CYP6AE23
CYP6AE20v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
56% to CYP6AE11
CYP6AE20v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_160 has 3 aa diffs to CYP6AE20v1
including an internal stop codon (not in HAH012568)
HAH012568 has 1 aa diff to Contig_160 at an internal stop codon
CYP6AE21 Bombyx mori strain Laos
GenEMBL EF432657
Dong Wang
submitted to nomenclature committee Oct. 2, 2007
94% to CYP9AE3P
MSVSALVFAAFVLLVTYIYYWSTRKFEYWKRKNVPYAKPVPFFG
NYMRYITLQSYIGDVMQKLCQQFPDRPYFGSFYGTEPALVLQNPEIIKQVFTKDFYYF
NSRDNSDYNHKEVVTQNLFFANGDKWKVVRQNLTPLFSSSKMKNMFYLVEKCNHSLED
MLDRETKDLQIIEIRAAMIRYTLDSICSSAFGIETNTLSEGGEYSPFANMASIIFSPS
IARGLKWISRSMWPGIFYKLGLQCFPAEIDDFFERLLTEVFENRGCKPTNRNDFVDLI
LSLKQNDYLTGDGLVPKNVDAKKVTVKVDDALLIAQCVVFFGAGFETSATTLSAALYE
LAKNPEAQRRAQEEVDELLLKHNNKLNYDCLAELPYLEACMNEAMRLYPVFPNITRET
VADYTFPDGLRIDKGMRVHVPVYAIHRNPDNFPDPEEFRPERYLGDAKNDIKQFTFFP
FGEGPRICIGMRFGKMQTIAGLITCLKKFNFELADGMPRTLAFRSTTLLTQLSTGLFL
KATPRDGWEQRIFAR
CYP6AE22v1 Bombyx mori strain Laos
GenEMBL EF528485
Dong Wang
submitted to nomenclature committee Oct. 2, 2007
4 amino acid differences to CYP6AE22v2
MYVLTFLLHFILFLVLVVYYITKRNHDYWKNKKVPFEKPYPILG
NYGDYILLKIFFGNVTKRLCEKFPESPYVGTFYGTEPALVVQDPDLIRLILVKDFFYF
HGREVCIYVDREITTQSIFFTYGDDWRVLRHSLTPLFTTSKMKNMFHLIKNCCRVFEN
VLEEKATVKSFEINSIIKYFIMDCVGACLFGVEINAMEKHSQNPIVKISKEIFPKSTT
RGIINVLRGIWPSLFYALRLKLFPEVITMFFTDLLECAFKDRQRNLSQRQDFIDLFMK
LRQNKYLVGDSIPDIKNGRVQKVNLEVTDELLIAQCVSFFGAAFETSSTTLSLTFYEL
AKNPKYQKRAIEEVDDYFAKHNNEIEFDIVSETPYLNACIDETLRLYPSLANLTREVM
EDYTFPTGLKVEKGTRIHIPVYHLQRNPKYFPEPNKFDPRRFLPEAKQTIYPFTYMPF
GEGHRICIAMRFAKMQMLAGFATLLKKYEVAVDDTTPQELTIDPRIIVTTPIENIQLK
LIARQHAL
CYP6AE22v2 Bombyx mori (silkworm)
Matches Cyp6AEhh
See silkworm page for sequences
Note: this sequence has had a name change from CYP6AE9 to CYP6AE22v2
CYP6AE23 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000205
95% to Contig_160 CYP6AE20v2
96% to CYP6AE20
CYP6AE24 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_169 57% to CYP6AE8 Bombyx,
56% to CYP6AE12 Helicoverpa armigera
HAH003329 has 3 aa diffs to Contig_169
CYP6AE25 Ostrinia furnacalis (Asian corn borer)
No accession number
Fengshan Yang
The same seq. was also submitted on Jan 5, 2009 by Yuliang Zhang
submitted to nomenclature committee Feb. 16, 2009
59% to Cyp6ae12
CYP6AE26 Epiphyas postvittana (Light brown apple moth)
EV813520 EST from male antennae
56% to CYP6AE12v1
MVLVASCRLILGTLVALAVAIGYLIL
SHKYSFWKRYGLPTPKHLPLLGNYADFILMRKNLGDTFTEICKQLPNEPIIGTYYGTEPA
VVVKDPELLKLIITKDFYYFSSRELRDHVHKETSTKNVFSAEGDYWRVIRQNLTPVFSSA
KMKKMFHLIQKRTAEYEKVLAKEIRENPIHDARSFNTRFTMDCIGSCMFGVDTNAMSSAA
NENPFRIISDKILDFSPLKLSKVIFRSIFPTIFYALKMEAFPKEANVFFEDLVKNVFKDR
NYKPGSRNDFVDFMLSFKQNDYLEGDEIKSLKIKDGSTGKIKLSVDDEMLVAQCLVFFAA
GFETSTATMSFTLYELAKKPEVLQKVLDEVDEHMKKHDGKITYDCVTELPYLEACIDESL
RLYPVLGGLTREVIEDYTLPSGVVLKKGVRVHIPVYYLQKHPDYFPEPEDYRPERFLGEN
KQDIKPFTYYPFGEGPRICIGMRFARMQMMAGLVTLLKDYTVELPPSTPRQVTFTPHAFT
TQTKEELKLKFLPRRVLAA*
CYP6AE27 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_ c6669
51% to 6AE8 Bombyx, 52% to CYP6AE11 Helocoverpa armigera,
a probable ortholog to the CYP6AE subfamily of moths
CYP6AE28 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
Submitted to nomenclature committee April 13, 2009
clone name: CM6-1
56% to 6AE12 Helicoverpa armigera
55% to CYP6AE1 AY295774 Depressaria pastinacella parsnip webworm
CYP6AE29 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6AE30 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
submitted to nomenclature committee Aug. 13, 2009
52% to CYP6AE28
CYP6AE31 Manduca sexta
No accession number
Yannick Pauchet
CYP6AE32 Manduca sexta
No accession number
Yannick Pauchet
CYP6AE33 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
47% to CYP6AE12v1 Helicoverpa armigera
CYP6AE34 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
48% to CYP6AE32 Manduca sexta
CYP6AE35 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
49% to CYP6AE32 Manduca sexta
CYP6AE36 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
56% to CYP6AE9v1 Bombyx mori
CYP6AE37 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
78% to CYP6AE17 Helicoverpa armigera
CYP6AE38 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
CYP6AE39 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
85% to CYP6AE17 Helicoverpa armigera
CYP6AE40 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
55% to CYP6AE33 Heliconius melpomene
CYP6AE41 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
54% to CYP6AE33 Heliconius melpomene
CYP6AE42 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
53% to CYP6AE33 Heliconius melpomene
CYP6AE43 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
63% to CYP6AE23 Helicoverpa armigera
CYP6AE44 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
87% to CYP6AE10 Spodoptera exigua
CYP6AE45 Plutella xylostella
Gene number CCG003246.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Complete, 86% to CCG017253.1
55% to CYP6AE12v1 Helicoverpa armigera
CYP6AE46 Plutella xylostella
Gene number CCG017253.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Probably missing first 23 aa
CYP6AE47 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
75% to CYP6AE24 Helicoverpa armigera
CYP6AE48 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
88% to CYP6AE10 Spodoptera exigua
CYP6AE49 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
80% to CYP6AE43 Spodoptera frugiperda
CYP6AE50 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
62% to CYP6AE24 Helicoverpa armigera
CYP6AE51 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AE52 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AF1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPq3l1
Note: CYP6AF1 and CYP6AF2 are nearly identical duplicate genes
CYP6AF2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPq3l2
Note: CYP6AF1 and CYP6AF2 are nearly identical duplicate genes
CYP6AF frag. Anopheles funestus
No accession number
Submitted by Ashley Vaughan, Dolphine Amenya, Hilary Ranson,
Lizette Koekemoer, on Sept. 9, 2004
78% identical to both CYP6AF1 and CYP6AF2 I-helix to heme
it is not known if A. funestus has the same gene duplication
as A. gambiae, so this sequence cannot be named yet.
CYP6AG1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPh2r1
CYP6AG2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPh2r3
CYP6AG3 Aedes aegypti (yellow fever mosquito)
CYP6AG4 Aedes aegypti (yellow fever mosquito)
CYP6AG5 Aedes aegypti (yellow fever mosquito)
CYP6AG6 Aedes aegypti (yellow fever mosquito)
CYP6AG7 Aedes aegypti (yellow fever mosquito)
CYP6AG8 Aedes aegypti (yellow fever mosquito)
CYP6AG9 Culex pipiens
CYP6AG10 Culex pipiens
CYP6AG11 Culex pipiens
CYP6AG12 Culex pipiens
CYP6AG13 Culex pipiens
CYP6AG14 Culex pipiens
CYP6AG15 Culex pipiens
CYP6AG16 Culex pipiens
CYP6AH1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2l4
CYP6AH1 Aedes aegypti (yellow fever mosquito)
CYP6AH2 Culex pipiens
CYP6AH3 Culex pipiens
CYP6AJ1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3l3
CYP6AK1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3l2
CYP6AK1 Aedes aegypti (yellow fever mosquito)
CYP6AK1 Culex pipiens
CYP6AK1-de1b Culex pipiens
Pseudogene
CYP6AL1 Aedes aegypti (yellow fever mosquito)
CYP6AL1 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I1.2
CYP6AL2v1 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1.2
CYP6AL2v2 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I2.3
CYP6AL3 Aedes aegypti (yellow fever mosquito)
CYP6AM1 Homotermopsis sjostedti (termite)
No accession number
Richard Cornette
Submitted to nomenclature committee Jan. 20, 2004
CYP6AM2 Blattella germanica (German cockroach)
No accession number
Ameya D. Gondhalekar and Mike Scharf
submitted to nomenclature committee Nov. 21, 2010
53% to CYP6AM1 in the N-terminal only
CYP6AN1 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
54% to 6AB1, 6AB2, 6AB3 C-term frag. 197 aa
seq #2 HaCypZ005a-v2Pep
CYP6AN1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_171 100% to CYP6AN1 from Vladimir Grubor,
60% to CYP6AN2 Bombyx,
55% to CYP6AB4, 53% to CYP6AB9
the CYP6AN and CYP6AB subfamilies overlap
CYP6AN2 Bombyx mori (silkworm)
no accession number
see silkworm page for details
CYP6AN3 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_241 89% to CYP6AN1, 61% to CYP6AN2 Bombyx, 54% to CYP6AB4
the CYP6AN and CYP6AB subfamilies overlap
CYP6AN4 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Nov. 21, 2008
77% to CYP6AN1 Helicoverpa amigera
81% to CYP6AN3 partial seq, 62% to CYP6AN2 Bombyx
CYP6AN4 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
94% to CYP6AN4 Spodoptera frugiperda (ortholog)
CYP6AN5 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6AN6 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
85% to CYP6AN1 Helicoverpa armigera
CYP6AN7 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
87% to CYP6AN1 Helicoverpa armigera
CYP6AN8 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
85% to CYP6AN1 Helicoverpa armigera
CYP6AN9 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
56% to CYP6AN5 Manduca sexta
CYP6AN10 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
83% to CYP6AN9 Heliconius melpomene
CYP6AN11 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
56% to CYP6AN5 Manduca sexta
CYP6AN12 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
59% to CYP6AN4 Spodotera frigiperda
CYP6AN13 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
92% to CYP6AN12 Heliconius melpomene
CYP6AN14 Plutella xylostella (L.) (diamondback moth)
CYP6AN15v1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AN15v2 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AN16 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP6AP1X Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
51% to 6P5 (58/113aa), C-term frag. 144 aa seq #8
renamed CYP337B1 54% (76/140aa) to 337A1 over a longer range
this partial sequence clusters with CYP337A1 and A2 on trees.
CYP6AQ1 Apis mellifera (honeybee)
WGS section genbank
ESTs = BE844578, BE844462, BE844394, BE844353, BE844352,
BE844331, all ESTs from antennae
Submitted by May Berenbaum 2/11/04
AmGroup12.14
Am2_12.16 (1067523-1070348),
45% to CYP6K1, 42% to Cyp6g2
CYP6AQ2 Philotrypesis sp5 (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
sequence 2
50% to Philotrypesis sp. 6AS21, 51% to Philotrypesis sp1 6AS22,
49% to Philotrypesis pilosa 6AS20,
51% to CYP6AQ1 Apis, 49% to 6A5 housefly
this seq missing 5aa at heme signature compared to 6AQ3
CYP6AQ is one of 5 clear subdivisions in the CYP6 family in wasps
These clades are deeper than typical subfamilies.
CYP6AQ3 Philotrypesis sp5 (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
sequence 3
52% to Philotrypesis sp. 6AS21, 53% to Philotrypesis sp1 6AS22,
51% to Philotrypesis pilosa ^AS20, 46% to CYP6CK1
only diff with CYP6AQ2 is a 5 aa insert
51% to CYP6AQ1 Apis, 51% to 6A5 housefly
68% TO Nasonia Nv6-22i and 53% to Tribolium 345A1
68% to Nasonia Nv6-23, 65% to Nv6-P2 and CYP6AQ1 Apis
CYP6AQ4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AQ5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AQ6P Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AQ7 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AQ8 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AQ9 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AQ10 Linepithema humile (argentine ant)
No accession number
CYP6AQ11 Linepithema humile (argentine ant)
No accession number
CYP6AQ12 Linepithema humile (argentine ant)
No accession number
CYP6AQ13 Linepithema humile (argentine ant)
No accession number
CYP6AQ14 Linepithema humile (argentine ant)
No accession number
CYP6AQ15 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
69% to CYP6AQ10 Linepithema humile
CYP6AQ16 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
69% to CYP6AQ10 Linepithema humile
CYP6AQ17 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
76% to CYP6AQ14 Linepithema humile
CYP6AQ18 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
61% to CYP6AQ10 Linepithema humile
CYP6AR1X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.19
Am2_5.8 (434944-432195),
50% to CYP6AS1
renamed CYP6AS19 as part of a larger clade
that became obvious with inclusion of wasp P450s from Nasonia
CYP6AS1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.5496
Am2_Un.5363 (3492-1105),
44% to CYP6A14, 64% to 6AS3
CYP6AS2 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.792a
Am2_Un.476 (25830-23485)
86% to 6AS1
CYP6AS2P1 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5353 (3026-2045)
92% to last 3 exons of CYP6AS2
CYP6AS3 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.792b
Am2_Un.476 (20769-18418)
64% to 6AS1
CYP6AS4 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.1753
Am2_Un.476 (1718-4379)
80% to 6AS6
CYP6AS5 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.42a
Am2_Un.4238 (9913-6869)
56% to 6AS1
CYP6AS6X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.42b
Am2_13.15 (124021-121751)
80% to 6AS4
renamed CYP6AS17 and CYP6AS18
two very similar genes, not alleles
CYP6AS7 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.42c
Am2_13.15 (119129-116557)
66% to 6AS4
CYP6AS8 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.4533
Am2_13.16 (153493-156158)
65% to 6AS9
CYP6AS9P Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2792
Am2_13.17 (7981-5161)
65% to 6AS8, frameshift at RNHL and bad boundary at EXXR
CYP6AS10 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2631
Am2_13.17 (13740-10480)
53% to 6AS8
CYP6AS11 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_13.16 (147797-150778)
Looked like a pseudogene in ver 1.2 now looks whole
83% to 6AS8
CYP6AS11-de1b Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_13.16 (152312-152647)
only 6 amino acid differences to 6AS11 in an 11 amino acid window
alternative exon 1
CYP6AS12 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.476 (9611-6794)
Looked like a pseudogene in ver 1.2 now looks whole
64% to 6AS9
CYP6AS13 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5370 (9442-11518),
63% to 6AS2
CYP6AS14 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_13.16 (142794-146154),
73% to 6AS8
CYP6AS15 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.210 (2742-6273)
68% to 6AS8
CYP6AS16 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.5370 (792-4695),
64% to 6AS9
CYP6AS17 Apis mellifera (honeybee)
Am3_13.15 (12051-14321),
497 aa, 5 exons, 5 aa differences between CYP6AS6v1 and CYP6ASv2
version 2 = CYP6AS6 Am2_13.15 (124021-121751), 497 aa, 5 exons
version 1.2 = CYP6AS6 Am1.2_13.15c (120924-123194) minus
version 1.1 = CYP6AS6 Am1.1_Un.42b (121844-124324) minus,
41% to 6a17, best matches all CYP6As 80% to 6AS4
name changed from CYP6AS6v1, two genes, not alleles
MFDYFQILIAFVASFLALYYYLTSNFDFWKNRNVVAPKPIPFFGNTKDVVLKKIEISNFIA
ELYKKYENEAMFGIFFGGSPNLILRDLDLIKDVLIKDFSTFDERGFKISER (0)
ADPLNANLFNMDVTRWRPLRIKLSPVFTSGKLKEMFPLILKCAERLEQCLEDAVKRGGPVD
CFEISARYTTDVIGSCAFGINMNALSDERSEFRRIGKRIFDLDKNILRSFLRQFFPRFYNL
LGFVIPYSETSKFVTKFISEMIKYREENNVVKADFVNLLMELKKHPEKLQNI (1)
KITDNLLAAQAFVFFAAGFETSSTTMAHALYEMALNPNIQDKLRKEIKEFYANNNFTYEEV
KKMKYLDKVFK (1)
ETLRKYPPGVFLKRKCNSNYTFKGTKVSIPAGTSVIIPVYSIQTDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRKCI (1)
GIRFGVYQTKVGLIKMLKNFKVNVCEKTMIPYIKKINSFTLAPKDGIFLKIEKNN*
CYP6AS18 Apis mellifera (honeybee)
Am3_13.15 (6830-9094), 497 aa, 5 exons
version 2 = CYP6AS6v2 Am2_Un.4238 (4309-2045), 497 aa, 5 exons,
completes on N-term what appeared to be a single exon fragment
in version 1.2
version 1.2 = CYP6AS6-se1[5] Am1.2_13.15a solo exon pseudogene
(132407-132573) minus, 54 aa, 1 exon
the two sequences are on AADG03005752.1 11483 bp apart
name changed from CYP6AS6v2, two genes, not alleles
MFDYFQILIAFVASFLALYYYLTSNFDFWKNRNVVAPKPIPFFGNTKDVVLKKIEISNFIA
ELYKKYENEAMFGIFFGGSPNLILRDLDLIKDVLIKDFSTFDERGFKISER (0)
ADPLNANLFNLDVTRWRSLRIKLSPVFTSGKLKEIFPLILKCAERLEQCLEDAVKRGGSVD
CFEISARYTTDVIGSCAFGINMNALSDERSEFRRIGKRIFDLDKNILRSFLRQFFPRFYNL
LGFVIPYSETSKFVTKFISEMIKYREENNVVKADFVNLLMELKKHPEKLQNI (1)
KITDNLLAAQAFVFFAAGFETSSTTMAHALYEMALNPNIQDKLRKEIKEFYANNNFTYEEV
KKMKYLDKVFK (1)
ETLRKYPPGVFLKRKCNSNYTFKGTKVSIPAGTSVIIPVYSIQTDPKFYENPDVFDPERFN
EDAVAARHPMTYLPFGDGPRKCI (1)
GIRFGVYQTKVGLIKMLKNFKVNVCEKTMIPYIKKINSFTLAPKDGIFLKVEKNN*
CYP6AS19 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.19
Am2_5.8 (434944-432195),
50% to CYP6AS1
formerly CYP6AR1
renamed CYP6AS19 as part of a larger clade
that became obvious with inclusion of wasp P450s from Nasonia
CYP6AS20 Philotrypesis pilosa (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
95% to Philotrypesis sp. 6AS21, 91% to Philotryp. sp4 sequence 1 6AS23
90% to Philotrypesis sp1 6AS22, 61% to CYP6AS4 Apis
probable ortholog of CYP6A21
78% to Nv6-8, 68% to Nv6-7i, 60% to Nv6-9, 63% to Nv6-27
note: on Feb. 18, 2008 Ying Liu sent a possible extension
of this gene into the middle region of the gene.
CYP6AS21 Philotrypesis sp. (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
95% to Philotrypesis pilosa 6AS20, 91% to Philotrypesis sp1 6AS22,
90% to Philotrypesis sp4 sequence 1 6AS23, 63% to CYP6AS4 Apis
probable ortholog of CYP6A20
80% to Nv6-8, 68% to Nv6-7i, 63% to Nv6-9, 63% to Nv6-27
note: on Feb. 18, 2008 Ying Liu sent a possible extension
of this gene into the middle region of the gene.
CYP6AS22 Philotrypesis sp1 (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
92% to Philotrypesis sp4 sequence 1 6AS23, 90% to Philot. pilosa 6AS20
91% to Philotrypesis sp. 6AS21, 64% to CYP6AS4 Apis
80% to Nv6-8, 68% to Nv6-7i, 64% to Nv6-9, 64% to Nv6-27
CYP6AS23 Philotrypesis sp4 sequence 1 (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
91% to Philotrypesis pilosa 6AS20, 92% to Philotrypesis sp1 6AS22,
90% to Philotrypesis sp. 6AS21, 64% to CYP6AS4 Apis
78% to Nv6-8, 68% to Nv6-7i, 65% to Nv6-9, 61% to Nv6-27
CYP6AS24 Philotrypesis sp4 sequence 2 (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
65% to Philotrypesis sp5 sequence 1 6AS25, 57% to CYP6AS4 Apis
57% to Philotrypesis sp1 6AS21
55% to fire ant EST EE143495.1 Lausanne fire ant
66% to Nv6-5, 63% to Nv6-6
CYP6AS25 Philotrypesis sp5 sequence 1 (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 28, 2007
65% to Philotrypesis sp4 sequence 2 6AS24, 52% to Philot. sp1 6AS22,
51% to Philotrypesis sp4 sequence 1 6AS23, 51% to Philot. pilosa 6AS20
52% to Philotrypesis sp. 6AS21, 50% to CYP6AS4 Apis
58% to Nv6-6, 56% to Nv6-5
CYP6AS26 Solenopsis invicta (Lausanne fire ant)
EST EE143495.1
63% to Nv6-28, 62% to 6AS2 Apis
CYP6AS27 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS28P Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS29 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS30 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS31 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS32 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS33 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS34 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS35 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS36P Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS37P Nasonia vitripennis (jewel wasp)
See wasp page
CYP6AS38 Apocrypta bakeri (fig wasp)
No accession number
Liu Ying
Submitted to nomenclature committee Feb. 18, 2008
Probable ortholog of CYP6AS20 (71% identical)
CYP6AS39 Linepithema humile (argentine ant)
No accession number
CYP6AS40 Linepithema humile (argentine ant)
No accession number
CYP6AS41P Linepithema humile (argentine ant)
No accession number
CYP6AS42 Linepithema humile (argentine ant)
No accession number
CYP6AS43 Linepithema humile (argentine ant)
No accession number
CYP6AS44 Linepithema humile (argentine ant)
No accession number
CYP6AS45P Linepithema humile (argentine ant)
No accession number
CYP6AS46 Linepithema humile (argentine ant)
No accession number
CYP6AS47 Linepithema humile (argentine ant)
No accession number
CYP6AS48 Linepithema humile (argentine ant)
No accession number
CYP6AS49 Linepithema humile (argentine ant)
No accession number
CYP6AS50P Linepithema humile (argentine ant)
No accession number
CYP6AS51 Linepithema humile (argentine ant)
No accession number
CYP6AS52 Linepithema humile (argentine ant)
No accession number
CYP6AS52-de5b Linepithema humile (argentine ant)
No accession number
CYP6AS53 Linepithema humile (argentine ant)
No accession number
CYP6AS54 Linepithema humile (argentine ant)
No accession number
CYP6AS55 Linepithema humile (argentine ant)
No accession number
CYP6AS56 Linepithema humile (argentine ant)
No accession number
CYP6AS57 Linepithema humile (argentine ant)
No accession number
CYP6AS58 Linepithema humile (argentine ant)
No accession number
CYP6AS58v2 Linepithema humile (argentine ant)
No accession number
CYP6AS59 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
71% to CYP6AS55 Linepithema humile
CYP6AS60 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
62% to CYP6AS52 Linepithema humile
CYP6AS61 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP6AS55 Linepithema humile
CYP6AS62 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP6AS52 Linepithema humile
CYP6AS63 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
73% to CYP6AS52 Linepithema humile
CYP6AS64 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
76% to CYP6AS52 Linepithema humile
CYP6AS65 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
71% to CYP6AS42 Linepithema humile
CYP6AT1 Phyllopertha diversa (scarab beetle)
No accession number
Walter Leal
Submitted to nomenclature committee Nov. 4, 2003
Clone name Cyp6Pd
43% to CYP6K1
CYP6AU1 Bombyx mori (silkworm)
BAAB01129923.1
40% TO 6B1
See silkworm page for sequence
CYP6AV1 Bombyx mori (silkworm)
BAAB01020563.1 BAAB01140967.1
44% TO 6AB1
See silkworm page for sequence
CYP6AW1 Bombyx mori (silkworm)
BAAB01195862.1 BAAB01153386.1 CK496233 EST
39% to CYP6P5
See silkworm page for sequence
CYP6AW1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
68% to CYP6AW1 Bombyx mori
formerly CYP6AW2
CYP6AW1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
74% to CYP6AW1 Bombyx mori
formerly CYP6AW3
CYP6AW1 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
98% to CYP6AW3 Heliothis subflexa
formerly CYP6AW3
CYP6AX1 Nilaparvata lugens biotype II (brown planthopper)
GenEMBL AJ852422, AJ629021 partial EST
Zhifan Yang and Guangcun He
Submitted to nomenclature committee Sept. 21, 2004
39% to CYP6A20 Drosophila pseudoobscura
full length sequence known but confidential
falls inside the CYP6 family on trees with all CYP6 subfams
clone sequence 1
CYP6AX2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 85% to 6AX1 Nilaparvata lugens
CYP6AY1 Nilaparvata lugens biotype II (brown planthopper)
GenEMBL AJ852423
Zhifan Yang and Guangcun He
Submitted to nomenclature committee Sept. 21, 2004
41% to CYP6M1, 40% to Cyp6a2
full length sequence known but confidential
falls inside the CYP6 family on trees with all CYP6 subfams
clone sequence 2
CYP6AY2 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf27 and sf28 two pieces probably from the same gene
88% to CYP6AY1 Nilaparvata lugens
CYP6AY3 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 83% to 6AY1 Nilaparvata lugens
CYP6AZ1 Mayetiola destructor (Hessian fly)
No accession number
Omprakash Mittapalli Richard Shukle
Submitted to nomenclature committee Nov. 22, 2004
43% to CYP6F1 from Culex mosquito, only 36% to 6BA1
clone name HFP450-1
CYP6BA1 Mayetiola destructor (Hessian fly)
No accession number
Omprakash Mittapalli Richard Shukle
Submitted to nomenclature committee Nov. 22, 2004
45% to CYP6Z3 from Anopheles, only 36% to 6AZ1
clone name HFP450-2
CYP6BB1v1 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY896792
Shaoming Huang
Submitted to nomenclature committee Jan. 7, 2005
Very close to CYP6P subfamily.
One CYP6P is above 55% identical but the rest are below 55%
Clone name G2-5-2
99.2% to CYP6BB1v2
CYP6BB1v2 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY896793
Shaoming Huang
Submitted to nomenclature committee Jan. 7, 2005
Very close to CYP6P subfamily.
One CYP6P is above 55% identical but the rest are below 55%
Clone name G2-5-3
98.8% to CYP6BB1v3
CYP6BB1v3 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY896794
Shaoming Huang
Submitted to nomenclature committee Jan. 7, 2005
Very close to CYP6P subfamily.
One CYP6P is above 55% identical but the rest are below 55%
Clone name G2-5-4
98.4% to CYP6BB1v4
CYP6BB1v4 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY896795
Shaoming Huang
Submitted to nomenclature committee Jan. 7, 2005
Very close to CYP6P subfamily.
One CYP6P is above 55% identical but the rest are below 55%
Clone name S7
98.2% to CYP6BB1v5
CYP6BB1v5 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL AY896796
Shaoming Huang
Submitted to nomenclature committee Jan. 7, 2005
Very close to CYP6P subfamily.
One CYP6P is above 55% identical but the rest are below 55%
Clone name S9
98.2% to CYP6BB1v4
CYP6BB1v6 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ059299.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone6BB1
Identical aa seq to 6BB1v3 and 6BB1v4, but nucleotide seq is different
partial seq, 420 aa
CYP6BB1v7 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427072.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 1-1
65% to CYP6P3, 1aa diff to CYP6BB1v5
partial seq, 84 aa EXXR to heme
CYP6BB1v8 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427076.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 13
65% to CYP6P3, 2aa diff to CYP6BB1v7
partial seq, 84 aa EXXR to heme
CYP6BB1v9 Ochlerotatus sollicitans (salt marsh mosquito)
GenEMBL DQ427083.1
Shaoming Huang
Submitted to nomenclature committee Feb. 5, 2006
Clone 25
65% to CYP6P3, 1aa diff to CYP6BB1v7
partial seq, 84 aa EXXR to heme
CYP6BB2 Aedes aegypti (yellow fever mosquito)
CYP6BB3 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/19/07
sequence 7
66% to CYP6BB1 salt marsh mosquito Ochlerotatus sollicitans
CYP6BB3 Culex pipiens
CYP6BB4 Culex pipiens
CYP6BC1 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_1.19 (858065-862228)
46% to 6AS7
CYP6BC2 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6BC3 Linepithema humile (argentine ant)
No accession number
CYP6BC4 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
81% to CYP6BC3 Linepithema humile
CYP6BD1 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_11.13 (431584-428990)
41% to 6AQ1
CYP6BD2 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6BD2-de4b Nasonia vitripennis (jewel wasp)
See wasp page
CYP6BD3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6BD4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6BD5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6BD6 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6BD7 Linepithema humile (argentine ant)
No accession number
CYP6BD8 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
73% to CYP6BD7 Linepithema humile
CYP6BD9 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP6BD5 Nasonia vitripennis
CYP6BD10 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 55% to CYP6DB2 whitefly Trialeurodes vaporariorum
92% to CYP6DB5 Sogatella furcifera
CYP6BD11 Plutella xylostella
Gene number CCG003086.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
66% to CYP6BD5 Nasonia vitripennis
CYP6BE1 Apis mellifera (honeybee)
Version 2 Baylor College of Medicine
Submitted by Reed Johnson 2/9/05
Am2_Un.1086 (577-5116)
42% to 6AS2
CYP6BE2 Linepithema humile (argentine ant)
No accession number
CYP6BE2-de2b Linepithema humile (argentine ant)
No accession number
CYP6BE3 Linepithema humile (argentine ant)
No accession number
CYP6BE4P Linepithema humile (argentine ant)
No accession number
CYP6BE5P Linepithema humile (argentine ant)
No accession number
CYP6BE6 Linepithema humile (argentine ant)
No accession number
CYP6BE7 Linepithema humile (argentine ant)
No accession number
CYP6BE7-de6b Linepithema humile (argentine ant)
No accession number
CYP6BE8 Linepithema humile (argentine ant)
No accession number
CYP6BE9P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
66% to CYP6BE6 Linepithema humile
CYP6BE10P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
62% to CYP6BE1 Apis mellifera
CYP6BE11P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
75% to CYP6BE6 Linepithema humile
CYP6BF1v1 Plutella xylostella (L.) (diamondback moth)
GenEMBL AY971374
Hongshan Li
Submitted to nomenclature committee June 8, 2005
Clone name msword
3 nuc diffs and 1 aa diff to CYP6BF1v2
CYP6BF1v2 Plutella xylostella (L.) (diamondback moth)
No accession number
Hongshan Li
Submitted to nomenclature committee June 8, 2005
Clone name A3b3
3 nuc diffs and 1 aa diff to CYP6BF1v1
CYP6BF1v3 Plutella xylostella (L.) (diamondback moth)
No accession number
Hongshan Li
Submitted to nomenclature committee June 8, 2005
Clone name A1
96% at the nucleotide level and 1 aa diff to CYP6BF1v1
CYP6BF1v4 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee Nov. 17, 2005
Clone name Sequence 1. 6XYr21 (Full cDNA sequence)
98% identical to 6BF1v1, 6BFv2 and 6BFv3
CYP6BF1 Plutella xylostella
Gene number CCG013145.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
complete
CYP6BG1 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee June 12, 2005
Clone name sequence 1
62% to CYP6AE1 but only I-helix to heme fragment
69% to CYP6BG2
CYP6BG2 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee June 12, 2005
Clone name sequence 2
55% to CYP6AE1 but only I-helix to heme fragment
69% to CYP6BG2
CYP6BG3 Plutella xylostella
Gene number CCG014217.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
incomplete
CYP6BG4 Plutella xylostella
Gene number CCG005902.4
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Complete, 96% to CYP6BG5
CYP6BG5 Plutella xylostella
Gene number CCG014216.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
complete
CYP6BH1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee June 29, 2005
39% to 6N3
CYP6BH1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P6BH203 r1e10
64 amino acids from heme to end
100% to CYP6BH1v1
CYP6BH1v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee June 29, 2005
39% to 6N3, 100% to CYP6BH1v1 at amino acid level
4 nucleotide differences
CYP6BH1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP3 clan
Clone name seqs. 10 and 26
100% to CYP6BH1 Leptinotarsa decemlineata
two partial sequences
CYP6BH2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-13
87% to CYP6BH1v2 Leptinotarsa decemlineata
53% to CYP6ED1 (P-6-1), C-helix region
CYP6BJ1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee June 29, 2005
46% to 6M1
CYP6BJ1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P6BJ7946
64 amino acids from heme to end
100% to CYP6BJ1v1
CYP6BJ1v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P6BJ146c61
61 amino acids from heme to end
98% to CYP6BJ1v1, 1 aa diff
CYP6BJ2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P6BJ42c63
64 amino acids from heme to end
92% to CYP6BJ1v1, 5 aa diff
CYP6BJ3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-9
87% to CYP6BJ1v1 Leptinotarsa decemlineata (aa 166-251)
CYP6BK1 Tribolium castaneum
GenEMBL XP_970556
67% to CYP6BK2
MFSVLVFLIIVVVFLYYKWAFTYWHRRNIPYLEPSFPFGNLPNLFQRKENIGLTVEKFYNEMKRRKWKHG
GVYFLVSPVYCVIDLEYVKNIMNRDFEYFTNRSIYYNEKDDPLSAHLFAIGGQKWRNLRTKLTATFTSGK
MKAMFQTLLECETNLLKQIEDCNNPINIKEILSCFTTDVIGSVGFGLECKTFEEKNSPFRIYGKKVFKDS
VLRSLKRAFLTSNFPELARKLGILAFPSEITDFFLKVVADTVKYREENNRSRNDFLQLLIDLKNSGTLSL
EEIAAQCFLFFLAGFETSSTTMTFALYELAQHQDIQDKVREEIDAVLKKYGGKITYEAIHDMKYMNQVID
ETLRKYPAASIITRTCVKDYKIPDQDIVIEKGTSVIIPVLGIHHDEKFYPNPEKFDPERFTEENKAARHH
YAHLPFGEGPRICIGMRFGLVQSKVGLTSLLKNYIFKVNKKTIEPLKMQARSLILAAEGEIWLDVYKL
CYP6BK2 Tribolium castaneum
GenEMBL XP_970481
65% to 6BK4, 67% to 6BK1
MLFSDSLTKDLFGCVLTFAILIIAYFKWSYQYWKRKNLPYLKPTFPFGNITGLLTRKETFGVIIQKVYQE
MKNCNWNHGGIYLTLNPAYCAIDLEYVKNIMTKDFQHFVDRGSYYNEKDDPLSAHLFAIGGQKWRNLRTK
LTPTFTSGKMKQMFQTLVDCESNLAKKIDMEYEKKHPIDIKEVLGCFTTDIIGSCAFGLDCKTFEHENSP
FRVYGKKLFKGSTLRNIKRSLLTQNFPDLAQKLGVLALPEDISNFFMKVVKDTVRYREKNGFTRSDFLQL
LINLKNSKVAEEEGYKHDGNTLTLEEIAAQSFVFFIAGFETSSTTMTFALYELAKNQEIQSQVREEIDAV
LKKHDGKITYDSIQDMKFMNQVIDETLRKYPPIPFVTRKCVNNYQIPGENIVIEKGTTVIIPILGIHYDK
DYYPNPEKFDPERFTEKNKNARHHYAHIPFGEGPRICIGARFGLMQTKVGLISLLRNYKFTVNNMTREPL
RMQVDSFVLAAEGEIWLDAHKL
CYP6BK3 Tribolium castaneum
GenEMBL XP_966437 or XP_975753
changed C-term seq on XP_975753
this end is a better match to
CYP6BK4 and is probably the correct C-term
MFVSNSLLGDLIALFVTLGVLLTFYFKWTYQYWTRRNVPQIDPHIPFGNISESIKGREIVGVTFKKIYQQ
LKSQGCRHGGIYIFTQPSYFPIDLDYIRNILTKDFQYFVDRPFYVNEKDPLQAHLLNLSGTRWRNMRSKL
TPTFTSGKMKLMFHIMAESQSDLLKRMDKEAESLEPINIKEVLACFTTNIIGSCAFGLDCKALEDENSPF
RQFGKKLFKISVLHRLKRTFAATFPDFAKFLRMSNSRKEIVKFIMDMVEGTIEYREKNNYSRNDFMQLLI
DMKNNKPKGDHDGKPLTLDEVASQAIVFFAAGFETSSTLMTFAFYELAKNPHIQDKLREEINLILAEHNN
EISYDAIQEMKYLSQVIDETLRLHPPAAQTSRKCIKDYKIPDQDITIEKGTSVTVSILGIHHDPDYYPDP
EKFDPERFTEENKSLRHNYAFLPFGEGPRNCIGMRFGLLQSKMGLVSLIKNYKFTVNEKTK
EPITYQPAHVVLAAQGEIWLNAQKV
CYP6BK4 Tribolium castaneum
GenEMBL XP_970415
65% to 6BK2
MLITTSLTGDLLAVFLTLVLIIVTYCKWSYQYWERKHLPYLEPQIPFGNVGDSIKGKTNFGITIKKIYEE
MKHNGWKHGGLYVFTEPNYMVLDLEYVKNIMTKDFQYFVDRSTYYNKKEDPLNAHLLNLGGTKWRNLRTK
LTPTFTSGKMKMMFQTLADCQTGLLKRMEKERLTRQPIDIKEVLACFTTEIIGSCAFGLNCKAFEDENSP
FRVYGRKVFATSKLQRLKRTIATIFPTLGYLFNISITPKDITNFYLNVVKDTVEYREKNNYNRNDFMQLL
IDLKNNKLEGGTSNGGFTLKEVAAQSFVFFLAGFETSSTLMTFALYELARHQEIQDIVREEINEVLRKHN
GNVTYDSINDMKYLSQVIDETLRLYPPASLVNRKCIKDYQVPDCDLVIEKGTTVLIPIMGIHYDKDYYPD
PEKFDPERFTEENKNARHNYAHIPFGEGPRICIGMRFGLMQTKVGLSCLLKHYKFTVNKRTQEPLKMQPS
PLILSAEGEIWLDAEKL
CYP6BK5 Tribolium castaneum
GenEMBL XP_970347, AAJJ01005400.1 has exact match, runs off the end
73% to 6BK2
1 IGDFFLKVVKDTVNYREKNNFTRKDFMQLLIDLK
105 NNKLVGEEGKSERGLTIEEVAAQSFVFFLAGFETSSTTMTFALYEMAKHQDIQAKVREEIDT
VLKKHDGKITYEAIQEMKYMGQVID (1) 365
2242 ETLRKYPPVPFLTRQCVKDYKIPNEDVTIEKGTTVIIPVLGIHYD
KDIYPDPEKFDPERFTEENKNARHNYSHIPFGEGPRICIGMRFGLMQSKVGLTSLLKKYKFTVNKKTQEP
IKFQVNPFILAAEGEIWLSAEKI* 2658
CYP6BK6 Tribolium castaneum
GenEMBL XP_970282
76% to 6BK12
MFRFLDLVGVFIALFAILFAYFKWTYQYWSQKNVPFIQPTIPFGNSNLFRQKESGGIRMKNFYDEMKAQG
WKHGGLYSILKPSYMVIDLDYLKNIMTKDFDYFSDRGFYYNEKDDPLSAHLFAIGGEKWRNLRIKLTPTF
TSGKMKMMFQTLVDCAPGLVKQIDRKMESIDIKEVLGCFTTDIIGSCAFGLDFNTSNDNNSPFREYGRKA
FVPTKFDIVKIIFAMSFPRLAQLFRLTLTRKDVSEFFLKVVRETVEYREKNNYRRKDFIQLLIDLKGEDG
KTLTINEIAAQSFVFFIAGFETSSTTMAFVLYELSRRPDLQQKLRDEINTVLSRYEGSITYEATQEMKYM
DQVINEALRMYPPVPMLGRKCVKDYKIPDQDVIIEKGTSILIPVLGIHYDQEYYPDPKTFDPERFNEENR
KARHHYAHLPFGEGPRICIGMRFGLMQTKVGLATLLKNYKFKVGERTQEPLKFKVASFVLAAEGEIWLDAEKL
CYP6BK7 Tribolium castaneum
GenEMBL XP_970215
67% to 6BK6
MFTFVGVAIALLATLFAYFKWTYKYWERRNLQYLEPKIPYGNGTGPFKRTENAGFRFKRQYEELKSRGWK
HGGLYSILNPIYLVADLDYIKNIMTKDFHYFTDRGIYYNEKNDPLSAHLFALGGPKWRHLRTKLSPTFTS
GKMKQMFQTLVDCVPQLLQQIDKNVPVDIKEVLGCFTTDIIGSCAFGLECKTFEDENSPFREYGRKFFQV
SNLKIAKFLFSGNFPNVARTLGVTITSKDVSDFFISVVEDTVKYREKHNLVRKDFMQLLIDLKNTEKEQM
LTIEELAAQCFVFFIAGFETSSTTMTFALFELAKRPDLQQQVRDEIETVLAKHGNITYDAIQDLKFMDQV
IDETLRMYPPVPVLTRKCVKDYKIPDQDVIIQKGTRVFIPVLGIHYDSDLYPNPSQFDPDRFSEEKKKSR
HGYAHLPFGEGPRICIGMRFGLMQTKVGLTALLKNYKFSVNSKTQTPLKMKPNSFILAAEGDVWLNAQKV
CYP6BK8P Tribolium castaneum
GenEMBL AAJJ01004329 Pseudogene
61% to 6BK11
3214 MFFDSISLNVLSVFIALTAVIFAYYKWTYHYWERQKLPFLTPTIPYGNILSPLSKTENFA 3035
3034 ITCKHLYNKIKQREWKHGGIYAILAPIYFVVNLDYVKNIMTKDFQYLDRGFYHKEKVDP 2858
2857 VSAHFFXXXXXX 2840
2823 QNKLTPTFTSGKMKMMFKTIADCEVNL*EKMLEEHE*KEPIDIKDILSCFTTDIIGSCAF 2644
2643 GLNCNSFKEENSAFRIYGRKVFTPTKTRVLRDTFSFNFPDLARRLNVRAFPKHIGDFFV 2467
2466 NMVKDTVNYREKNNFIRKDFMQLLIDLKNNKL 2371
2365 EEGKSERGLTIEEVAAQSFVFFLAGFETFSTTMTFALYELAKHQDIQDKVREEIDAVL 2192
2191 KKHDGK 2174
2172 AIQEMKYMGQVID (1)
EILRKYPPIPFLTRQCVKDYRIPEE 2012
2011 DVIIEKGTTVLIPVLAIHHDKDIYPNPEKFDPERFTEERKNARHNYAHIPFGEGPKICIG 1832
1831 TRFGLMQSKVGLTSLLKKYKFTVDN*TQEPIKFQVDSFILAAEGQVWLNAERV 1673
CYP6BK9 Tribolium castaneum
GenEMBL AAJJ01000871.1, one stop codon, possible pseudogene
65% to 6BK4, 67% to 6BK1
note this seq has P450s from 3760-6622, 22800-21300 (-) = CYP6BR1,
29500-31000 = CYP6BR2, 33000-38500 = CYP6BR3
46% to 6BE1 bee, similar to 6A and 6N subfamilies
3760 MMCILGVF
3784 IALLAVILTSYYKWSFQYWERKNLPYLKPTIPYGNITSPFNRKENIAVTIQNIYEEMKTR 3963
3964 GWRHGGIYTVTSPAYFLVNLDYVKNIMTKDFQHFVNRGFYHNENDDPVSAHLFAIGGSKW 4143
4144 RFLRTKLTPTFTSGKMKMMF*TLADCEINLQEKMQDEFEKNQPIDIKEILACFTTDIIDS 4323
4324 CVFGLDCNSFKEENLPFRQYGRKVFAATKFRVVRSTFAANFPDLARFLKVRTFPKDIGD 4500
4501 FFLKVVKDTVNYREKNNFTRKDFMQLLIDLKNNKLVGEEGKSERGLTIEEVAAQSFV 4671
4672 FFLAGFETSSTTMTFALYEMVKHQHIQAKVREEINTVLQKHDGKITYEAIQEMKYMGKVVD (1) 4854
6206 ETLRKYPPVPFLTRQCVKDYKISDEDVIIEKGTTVIIPVLGIHYDKDIYPDPEKFDPERF 6385
6386 TEENKNDRHNYAHVPFGEGPRICIGMRFGLMQSKVGLTSLLKKYIFTVNKKSKEPIKFQV 6565
6566 NSLILAAQGEIWLNAERI* 6622
CYP6BK10 Tribolium castaneum
GenEMBL XP_969948
55% to 6BK13
MSLLLSFLLRLGSVIISLIVVVLSVIKWKHQYWANRNIPFFPPSVPFGNLQNPRRKKHSIGYHIKNFYDQ
AKRKGWKHCGLYFFASPVYLVIDVNYVKHIMNTDFHHFVDRGMYSNEKIDPISAHLFALGGTRWKNLRNK
LSPTFTSSKMKMMFPTIVECVSLLLDAMTEKSEQIDIKELLGRFTTDIIGSCAFGLDCNTIKEENSPFRL
YGKKVFFSTKMRTFKLTFASSFPTLGRLLRIRQVSSDVSDFFRKIVKDTIEYRAQNQFSRPDFLQMLIDL
RRDGAEITLDEIIAQCFIFFLAGFETSSTTMTFTLYELAKNHQIQDKLRQEIMTILTKYHGEITYDAISE
MKYLDQVIEESLRKYPPLPFVTRTCVMDYKVPNTDLVIEKGRRVILPILALHHDPEFWPEPQNFDPERFN
DQNRNLRHQFSYIPFGEGPRFCIGKKFGLTQTKVGLVALIQNYKFSVNSRTLDPLKMAPNTFILSAAGGI
WLDSEKL
CYP6BK11 Tribolium castaneum
GenEMBL XP_968370
63% to 6BK4
MLLTNSICGDLVTIFLTLVTVLTLYFKWCHQYWEKLNLPSLPPSIPFGTSLGPKGHFGLRMKHIYDKMRQ
KGWKHGGIYLMQRPFYVVVDLDYVKNIMTKDFHHFSDRGIFHNEKADPLSAHLFNISGPKWRNLRSKLTP
TFTSGKMKLMFQTLLDCEVNLRKQVEQHYEAKKPIDIKEVLGCFTTDIIGSCAFGLDCNSFKEENSPFRV
YGRRVFDRSGFIRTLKRTFASNFPNLAKLVNIALVPRDISDFFINIVKDTVEYREKNKIVRNDFLQLLLD
LKTEESGNDGTALTFEEIAAQSFVFFIAGFETSSTTMAFALYELARHQDIQDQVRDEIESVLKKYDGKIT
YEAIQEMSFLGQVIDEALRMYPPGPLVPRRCVKDYKVPNTDVVIEKGVMVLIPILGIHYDEKYYPDPEKF
DPERFSEENKALRHSYAHIPFGEGPRICIGLRFGLMQSKVGLVSLLRNFKFTVNEKTQEPLKMKTNSLVL
AVEGEIWLNVHRL
CYP6BK12 Tribolium castaneum
GenEMBL XP_969107
94% to 6BK12
MPTLFDILGVSVALLVITYAYFKWRFQYWRQKNVPFLPPTVPFGNFNMLRQRDNGGILLKKFYDEMKSHG
WKHGGFYSLFQPGYLVIDLDYLKNIMTKDFDHFTDRGFYYNEKDDPLSAHLFALGGEKWRNLR TKITPTF
TSGKMKQ MFQILVDCTPDLIERIDSFCREKKPIDIKELLGCFTTDIIGSCAFGLQFNTSKDKNSPFREYG
RKAFTPTYFDIVKMTFAMAFPRLALALKLRMTRKDVSDFFLQLVRDTVKYRVENNYSRKDFIQLLIDLKS
LTIEEIAAQCFVFFIAGFETSSTTMTFVLYELSRRHDLQQKLRNEINTVLAKYDGHMTYEAIQDMKYMDQ
VINEALRMYPPVPLLSRKCVKDYKIPDQEIIIDKGTTVCIPIWGIHYDKDYYPEPEIFDPERFNEDNKKS
RHHYAHLPFGEGPRICIGLRFGLMQ TKVGLATLLQNYNFRVAGRTQEPLKYKVASFVLAAEGEIWLDAEKL
CYP6BK13 Tribolium castaneum
GenEMBL XP_969633
65% to 6BK14
MFSCFLTNIIGIFVAFFAVIIAFYKWSFGYWKQKNVPYLPPKIPFGNLANPLRPAENMGVQVQHFYAQMR
AKKWKHGGLFFLANPTYMVVDLEYVKNILTKDFQHFVDRGVYYNEDVDPIGAHLFALGGTKWRNLRTKLT
PTFTSGKMKMMFQTLIDCESNLHKKIQAQKNKPIDIKDVLGCFTTDIIGSCAFGLDCNTFEDEDSPFRKY
GKKVFVATPLERLKIAIFMNFPKVGRFFKMRQVSKDISDFYSKVVKDTVEYREKHNYSRKDFMQLLIDLK
NDGNALTLDEITAQSFIFFLAGFETSSTTMTFALYELAKNSEVQEKVREEVLAVLGKHGGKITYEAIQDM
KYMNQVLNETLRKYPPVPFITRQCIKEYKIPDQEIIIETGTRVIIPILGIHYDPEYYPDPQKFDPERFSE
ENVNKRHHYAHLPFGEGPRICIGLRFGLMQSKVGLASLLSKYRFKLNERTKQPMKFQVKSFVLAAEGEVW
LDAESL
CYP6BK14 Tribolium castaneum
GenEMBL XP_969713
65% to 6BK13
MEMLFSAIILILALNYFYYKWKFTYWQCKKIPTLAPKIPFGDLPNPLKQAEATGVHIKRLYDQIKGKGWK
HAGLYFLARPVYMVVDLEYVKNILTKDFHHFVDRGFYFNEKDDPISAHVFAVGGQKWRNLRTKLTPTFTS
GKMKMMFQTLLECEANLLKRFEKEHKSAIDIKDILGCFTTDIIGSCGFGLDFNTFEDENSPFRKYGKKVF
ASNLTRRLQIFFFTHFPSMARALKVRHFSKDVADFFTKVVKDTVEFRERNNYKRKDFMQLLIDLKNCNSG
LTLNEITAQSLIFFLAGFETSSTTMTFALYELAKNEKIQERVRDEIFSILGEEKITYEALQKMKYLALVI
NETLRKYPPLSFLTRECVQDYKIPDQDVIIEKGTKVVISILGMHRDQEFYPDPETFDPGRFSEGNVVSRH
QYAYIPFGEGPRICMGLRFGMMQTKVGLVSLLRKFKFTVNGRTKEPIKFDVRGFILAAEGDIWLNAQKVC
CYP6BK15P Tribolium castaneum
GenEMBL XP_969180 AAJJ01005841.1
76% to 6BK6
N-term 133 aa not found,
this is probably a pseudogene, since the most
similar seq does not have an intron here.
1415 TEVTPSFTLGKIKQ
MFKILVDCTPDLIERIDSFCREKKPIDIKEVLGCFTTDIIGSCAIGLQFNTSKDKNSLFREYGRKAFTPT
YFDLIKMSFAMAFPRLALAFKLRMTRKDVSDFFLQLVRDTVKYRVENNYSRKDFIQLLIDLQNLTNEEIA
AQCFVFFIAGFETSSTTMTFVLYELSRRQDLQQKLRNEINTVLAKYDGHMTYEAIQDMKYMDQVINEALR
MYPPVPLLSRKCVKDYKIPDQEIIIDKGTTVCIPIWGIHYDKDYYPEPEIFDPERFNEDNKKSRHHYAHL
PFGEGPRICI (1) 504
GLRFGLMQTKVGLATLLQNYNFWVAGRTQEPLKYKVASFILAAEGEIWLDAEKL* 294
CYP6BK16P Tribolium castaneum
GenEMBL XP_969554 AAJJ01002474.1
65% to 6BK13
three P450s on this contig 6BK13 11kb region,
6BK14 7kb region and this one in the 15kb region
short missing EXXR to end, pseudogene, this seq is not present before
the end of 6BK13 is found
MGMFFTQSLLTDVTTLVVTLTVILVTYYKWSYTYWRRRGVPSLTPKIPWGNLSNPLNRKDTIGVDVKKMY
DSMRRQNWKHGGVFFMASPVYLVTDLEYVKDILTKNFQNFVDRGLYYNEKDDPISAHLFAIGGPKWRNLR
TKLTPTFTSGKMKAMFQTLLDCESNLQEKVAAELGKNQAIDIKDVFGCFTTDVIGSCAFGLDCNTFKEAD
SPFRKYGKKVFTNTPIRQLKSSFSNSFPKLAQQFGISVMPKDVSDFFTKVVKDTVEYRQKNNYTRKDFMQ
LLIDLKGEGKQDGKSLTMDEITAQSFLFFAAGFETSSTTVTFALYELAKHQDIQQKVREEIETVLAKFDG
KVTYEAIQEMHYMNQVLNVTIIK 14679
CYP6BK17 Tribolium castaneum
No accession number
Jiang Hongbo
Submitted to nomenclature committee on Nov. 16, 2007
78% to 6BK10 (not found in genome assembly)
CYP6BK18 Dastarcus helophorides (parasitoid beetle)
KC683905
Haidong Wang
Submitted to nomenclature committee on Dec. 13, 2012
58% to CYP6BK2 Tribolium
CYP6BL1 Tribolium castaneum
GenEMBL XP_968293
49% to CYP6BK11
MLTSCLATLFITLLSIFAYFYKRFYFSYWERKKIPNLQQHVPRTKPHLGIQLQQLYKIMKEKKWKHGGFY
QQLSPVYVICDLNYVKNIMTRDFNYFPYRGLYYNETSDPLSAHIFNTSGAKWKRMRRKLDQIFTSSKLKT
IFPLLPNCGEKLAGKCEPVDIKKVLDDFISDVIELCVFGSECKVFKQLGRKILNRSRLRRLKGIIINNFP
KLAKILDIVLIPRDASTFFKKVVAEIVEERKKGQTGRNDFLQVLVEMEKKFEITIDEIAAQCFIFLIAGM
STSPTAMTFALYELARHQDIQEKVRQDIAKFGKVTYDSLQEMKYLGQVFDETLRMYPPAAYLNRKCERNY
EIPDGSGIIVEKGTIVAIPVLGIHYDRDYYPDPEKFDPEHFSEENKRLRPNFAFLPFGEGPRICIGMRFG
LMQSKLGLVSLLKRYKFTVSEKTREPLKMKPNSLVLSAEGEIWLDVTEIKI
CYP6BM1 Tribolium castaneum
GenEMBL XP_970825.1
52% to CYP6BK1
MAFISLTILAILLLLAVTLFYKWKFQYWKTRQVPFLPPKIPFGNIPNPFTLKEKPGIFIKQFYQEMKRNG
WKHGGFYFFACPVYMVVDPDYIKQVLIKDFQYFIDRGIYSNEKDDPISHNLFSANETKWKYLRTLLNPSF
TSKKIKAMFTILLACEKFLTQNVENNQVIDANHIFANFTIDVITTCAFGLDCNGNQNLALKHFGEKTINY
SKLKMFVLMLASIFPKLAKKFGCVIMHKNTQEFFVQFVADIIKFREENNYTRDDFMQFLIKLKNKSAKQV
FTLEEVASQCVLFFIAGFETSHATMSFALYELAKHQDIQQKVREEFWAVVDSQESEITYEAVQKLKYLDQ
VLNETLRKYPVVMYLTRRCIKDYKVPEDGAVIEKGTTVIIPTVALNYDENYYPNPKKFDPQRFSEENKKL
RHPCIHLPFGLGPRFCIGRRFALIQVKVGLVLLLKNYSFTVNPNTREPIKLKIHSFISAPEDKILLDVHKL
CYP6BN1 Tribolium castaneum
GenEMBL XP_969048
50% to CYP6BK1
MNTTIEILTIIILTIFCFYKWKFSYWKSRKIPYLDPKFPFGNVSNPFFMKEKVGMTLARFYNDMKQRGWK
YGGFYFGVSPICLIVDPDLIKNIVTRDFEHFVDRGVYFNEKDDPLSGHLANLDGQKWKNMRRKLNPTFSA
SKTKNMFPIVKFCVENMMEKVKSCYENAHKCCNINEVFPAFSINVICSCAFGLQEENALFKAYADECVSW
TKYKYLVQILATFFDKTAKRMGITTVPRNAAKFFMKVVTDSVKYREENDYVRSDFMQLLIEMKKQNQLTI
EEIAAQCFVFFIAGFETSSATLTFALYELAKNQNLQNVARDEILANCPNEITYDSLADLKFLDQVVDETL
RKYPPLLYVTRQCVKNYKIPDEDVVIEKGTLVAIPISALHSDEEFYPKPETFEPERFSKTEKSLRHPYTF
LPFGEGPRMCIGKRFGLLEVKLALTCLLKNYKFSVNCKTKEPLAMRVDTVVLAPKDEIWLDLEKI
CYP6BP1 Tribolium castaneum
GenEMBL XP_970699
49% to CYP6BN1
MILLVLSVVLLVALRIFFFWRFQYWEKLQIPYLRPYCPFGCLPNPLINKEKGGIILKRLYRNVRDKGWKH
AGIFVFVTPVYLPTNLDYIKNILTKDFEHFDDRGLYYNEKDDPLSGHLINLGGPKGVTMRKKLNSLFTPS
SLKMMFQTLNTSIEDLLQQIHSRNTIDIHKLFTCFTIHVIASCTLGLECNIFKEEHLLFESYANKFLVWS
RGKWCLQLLAAMYIDTARKLKVRTVPKETEDFFVKIVTKNIKYREENDYFRQDMMQFFIEQKNANTMSIN
EIIAQCFIFFIAAYETSTTTLTFALYELAQNLDIQDRVRREITSVLLKHQKYSYEAIAEMKYLNQIVDET
MRKYPPFLYVVRRCTKDYTIPGEDVTIKKGIFALISILGIHHDEEIYPNPQKFDPDRFSKENKKMRHPYA
YLPFGEGPRICIGKRFALMQIKFGLAALLEKYKFTLNEKTKVPLEIRTDTLVVAPKGDVLLDIQKIN
CYP6BP2P Tribolium castaneum
GenEMBL AAJJ01000994 pseudogene
between 6BM1 and 6BP1
14792 GSGYRGFYVFVTPVYLPTDLNYVKNILTNDFNYFNRRGIYYNEKDDPLGAHLINLSGKKK 14971
14972 HILRK 14986
15032 MIKAHKVAATFTIDIIFSCTLGLDCKTFKDKHSLLQYFLNKCLFWSKFRWFVQVLAAMN 15208
15209 GSVKQNKQNFFLEIVSILNIARK*LRE
15276 NNYVRKDLQMLINQKKSNAFSVSEITAQCLPFFDAGFDTSAATLTFALT 15422
EIAKNLEVQEIIRAEIGEINYEILLETRYLDQVID 15526
15571 KTLRKYPPVLFVPRRCCDDYRTP 15639
SSIVIEKGTFVLISIFGI 15709
15710 HHDQESAKFDPERFCRENKKLRHPYAYIPFGEGPRS*IG 15826
15871 KRFGLMQIKFFVASISKNYKLTKNPRTPEPLTIEVDRMVLLP*NDIFLDLVKVD 16032
CYP6BQ1 Tribolium castaneum
GenEMBL XP_975578
60% to CYP6BQ11
gene model too long at N-term shorten it
MNYTFLA
LFVTFLLGVISYLKWKLRYWDKKGLPTIPPKLPFGNLTDVIFGRKSFGEQFVEFYQILKAKGYRHGGIYF
GASPLYVPTDPEIVKHIMLVDFAHFSSHGGYVDEESDPLSGHLFNLDDIKWRNLRVKLTPTFTSGKMKMM
FQTLAEVSYNLKNVLDESVINKTPVDARDVLSRFGVDVISSVAFGLECDSLKDPNVSFRKYGKKAVDFDI
WVRIKLFMQVLLPHCVLRAIGHKFTKTEVEEFFMKSIRDVVEYREKNNIFRKDFMHLLIQLKNLGTVTDD
GQILDETSGSKEVGLTMNQVAAQAFVFFMAGYETSSSTITFALYELAMNPPLQDKLRDEINTILAKHDNK
LTYAAMMEMTYMEKVIQETLRKYPPLPIIMRLCTKDYVVPGTDIEIKKGVGVMIPVLGLQTDPEYFPDPD
VFDPDRFSEEKKKERPGFTWLPFGDGPRICIGMRFGMLQSKVALTTFIRNYRVKLNEKTKIPLKIDKGSF
TTRAEGGVWLNLEKLN
CYP6BQ2 Tribolium castaneum
GenEMBL XP_975576
95% to CYP6BQ4
MLLVNGSLTYDLVAILVTVLAGLVVYYKWAFTYWKKRGLEYLEPSIPFGNCASLFKAKYNFGEQFAEFYK
QFREKNLRHGGVFMFARPFYIPVDPAIMKDIMQKDFQHFVDRGFYVNEEIDPLSGHLFSLEGNKWKNLRA
KLTATFTSGKMKMMFETMSRCAEELDNYVNEASKRKETIDIKETLARFTTDIISSCAFGLESNCLKNPDT
KFRYYGKRTFQNTTWENLKNLIQFMTPMYLLNLVKFKTTKQDVEDYMLNLVKKTVDYREKNNVYRKDFLH
LLLQLKNKGKITDDETFLDNNNKSKEVALTINELAAQVFVFFAAGYETSSTAMTFTLYELCLNQKIQDKM
REEIKTVLAKHNNKISYEALMEMTYMEQALNETLRKYPPVPFLNRKCTKAYDVAGTNLHLDEGTMVVLPI
LGLQHDPEYYPDPSKYDPDRFSEENKNSRPPFTWMPFGEGPRICIGLRFGMLQAKVGLATLLENYKVTLS
QKTKTPLEMDCKTFITTTKEGIWLDFTRLN
CYP6BQ3P Tribolium castaneum
GenEMBL XP_975574, AAJJ01000063.1
87% to CYP6BQ5
12 P450s on this contig
14kb region XP_975572
NFHHFMNHGNYFDSENDPLTGHLFNLEDNK*KNLRVKLTPTFILGKIK
12032 MMFQTLADCASGPNTIMDEAAKNQTSLDIKDILARFTTDVIGSVAFGLECNSLKDPDVEFRKFGKRIFQI
DVLDRIKILLQLIFPRNVLQTMKMKTTKSEVKAFFMKAIRDTVNYREKNNIYRKDFMHLLIQLTNRGVVT
DDGNITSDQSKTDKALSLNELAAQVFVFFIDRFETSLTTMI 12574
YEIASNPQVQEKL*EEIVTTLSKYNGELSYNAIMEMTYME
LRKYPPLPLLTRQCTKDY
DPEYHP
RFNPERFSEENKKKRPNFT*ILFGE
GLRFEILQSKVGLTTLLRNLKLL*TKKNKVPLEMDKKAFVSSAEGG
VWIDVEKL
CYP6BQ4 Tribolium castaneum
GenEMBL XP_975572
95% to CYP6BQ2
MLLVNGSLTYDLVAILATVLAGLVVYYKWAFTYWKRRGLEYLEPSIPFGNCASLLKLKYSFGEQFAEFYK
QFREKNLRHGGVFMFARPFYIPVDPAIMKDIMQKDFQHFVDRGFYVNEEHDPLSGHLFSLEGNKWKNLRA
KLTATFTSGKMKMMFETMSKCAEELDNYVNEAAKREETIDIKETLARFTTDIISSCAFGLESNCLKNPDT
QFRYYGKRTFQNTTWENFKDVIQFITPTYLLDLVKFKITKPDVEDYMLNLVKKTVDYREKNNVYRKDFLH
LLLQLKNKGKITDDETFLDHNNKSKEVALTINELAAQVFVFFAAGYETSSTAMTFTLYELCLNQKIQDKL
REEIKTVLAKHNNKISYEAIMEMTYMDQALNETLRKYPPVPVLNRKCTKAYDVAGTNLHLDEGTMVVLPI
LGLQHDPEYYPDPSKYDPDRFSEENKNSRPPFTWMPFGEGPRICIGLRFGMLQAKVGLATLLGNYKVTLS
QKTQTPLEMDCKAFITTTKEGIWLDFTRLN
CYP6BQ5 Tribolium castaneum
GenEMBL XP_975570
65% to CYP6BQ11
added lower case seq to gene model
MNTLLHNFVYDFVALFATVLIGVLLYYKWKFTYWAKVGLPTLAPTFPFGDAKEVMLGRLTFGEQFLEFYK
KFRANGFKHGGVYFCLQQFYVPVDPEIIKHIMQKDFHHFMNHGNYFDSENDPLSGHLFNLEDNKWKNMRV
KLTPTFTSGKIK MMFQTLADCASGLNTIMDEAAKNQTSLDIKDILARFTTDVIGSVAFGLECNSLKDPDA
EFRKFGKRIFQIDVLDRIKILLQLIFPRNVLQTMKMKTTKSEVEEFFMKAIRDTVNYREKNNVYRKDFMH
LLIQLKNRGAVTDD gnitsdqsktdk
ALSLNELAAQAFVFFIAGFETSSTTMT FALYEIASNPQVQEKLREEIVTTLSKYNG
ELNYNAMMEMTYMEKVIFETLRKYPPLPLLTRQCTKDYLIPNTTIRLKKGDMVGIAAQALHYDPEYHPDP
EKFDPERFSEENKSKRPDFTWIPFGEGPRLCIGLRFGMLQSKVGLTTLLRNYKIALNKKTKVPLEMDKKA
FVSSPEGGVWLDVEKLE
CYP6BQ6 Tribolium castaneum
GenEMBL XP_975569
75% to CYP6BQ7
MTFMTESLIFDIVTIISTIVVLTIAFWKWKLSYWDRVGLPTLSPILFFGDTKDVLLGRLTFGEQFQELYK
KLKAKGLKHGGVYLGTRPFYLPTDPEIIKHIWQKDFQHFVNHGNYFDEEADPLSGHLFNLEDAKWKNMRV
KLTPTFTSRKMKMMFQTLADCTHGLKDIMDEGASSGSPVDIKEILGRFTTDIIGSVAFGLECNSLKDPNT
LFRMYGKKIFELSTGRRLHLFLQFILPERVLHAMKFKVTPSDVETFFMKVIRDTVGYREKNNVYRKDFLH
MLIQLKNRGTVTDDEKITEDNGKTGEKALTMNELAAQSFVFFAAGFETSSTTVTFALLELALNQDIQQKL
REEINTCLAKSNGELTYQAIMEMTYMDKVLQETLRKYPPVPFLTRRCTKDYTIPETSIKLRKGDHVGISV
VGIQNDPEYYPDPEKFVPERFNEENKNSRHPFTWMPFGEGPRICIGLRFGMLQSKVGLAALLKNYKITLN
SKTKMPIEMEKSSFITSVNGGVWLNVEKLS
CYP6BQ7 Tribolium castaneum
GenEMBL XP_975568
75% to CYP6BQ6
MLFSDSLIVDLVTIIST IVVVSIAYCKWKLSYWNNTGLPTLSPVFPFGDTKELLLGQKSFGEQFQDLYKE
IRAKGWKHAGVYLAIQPFYLPVDPKIIKHIWQVDFQHFVNHGNYINEEVDPLSGHLFNLEDAKWKEMRVK
LTPTFTSGKMKMMFQTLADCTHGLKTIMNECATSGTPIEIKDVLGRFTTDIIGSAAFGLECNSLKDPDST
FRKYGKKVFELQGWERIKVLAQFALPHSFLRAIKFKQTQSDVEKFFMKVVRDTADYREKNKIYRKDFMHL
LLQLKNRGKVSDDEKVTQENGKTGEKALTMNEVAAQAFVFFLAGFETSSTLMTFTLYELATNPDIQGKLR
EEINTVLAKHDGQMTYEAMMEMTYMEKVLNETLRKHPPIPFLFRRCTKDYTIPETSVKLRKGDDVGISIV
GIHNDPEYYPNPEKFIPERFNEENKNARPPFTWIPFGEGPRICIGLRFGMLQSKVGLTALLKNYKISLSS
KTKMPLEMEKSGLVTTVEGGMWLNVEKIN
CYP6BQ8 Tribolium castaneum
GenEMBL XP_975567
75% to CYP6BQ11
MLLNNFTLNILAVFITVLVGVIVYFKWHLSYWDRLGVPSLSPVLFFGDTKNLILSKCTIGEQFRVFYNKF
KSKGYKHGGIFFGPIPFYIAIDPEIIKHILQKDFQHFMNHGYYINEEDDPLTGHLLNLENVKWKNMRAKL
TPTFTSGKMKIMFQTLADCTTGLKKVMDDSALNHTPVDIKDIFGRFTTDIIGSVAFGIECNSLENPDAEF
RKYGKKVFEIDFFGRIKTLCTFAIPHPILRLFRFKFYNSDVATFFMDAIRETVNYREKNNIYRKDFMHLL
LQLKNRGLVTDDEKITGDKDIVTEALTMNELAAQAFVFFLAGFETSSTAMTWALYELAINPDVQQKLRAE
INDVLRKHNKLTYEAMMDMTYMEKVICETLRKYPPIPVLTRKCTKDYTIPNTSIQLQRGVSVSVPVLALH
TDPEYYPNPEKFDPDRFNDENVKARPGFTWLPFGEGPRICIGLRFGLLQSKVGLTAVLKHYRIKLNHKTQ
LPVTLNPRSFITSAKGGVWLDVEKID
CYP6BQ9 Tribolium castaneum
No accession number
Dr. Reddy Palli
Submitted to nomenclature committee Feb. 5, 2008
97% to CYP6BQ9P except it is not a pseudogene
CYP6BQ9P Tribolium castaneum
GenEMBL AAJJ01000063
between CYP6BQ8 and CYP6BQ10
78% to CYP6BQ11
lower case = possible duplication or intron seq, one stop codon
possible pseudogene
25815 MTLITNNLMFDLIAILATVLVCVIAYLKWHLTYWNRLGVPSLNPVLFFGDATDYLFGKCGVG
EQFAKFYGKFKSKGYKHGGVFLGPKCYYVPVDPDLVKHIMQKDFQHFMNHGFYINEEVDP
LTGNLFSLEDAKWRNMRVKLTPTFTSGKMKMMFQTLADCTRGLKEIMDNLALNHAPADIK
EILGRFTTDIIGSVAFGIECNSLKNPDAEFRKYGRKIVETGFIDRIKVFLVLSIPHALLR
FLRFKFTNTEVETFFMGAIQDTVNYREKNSVYRKDFMHLLLQLKNRGLVADDEKITDDKG
NIKENDFITINQLAAQAFVFFLGGFETSSTTMSWAL*ELATNQDIQEKLRKEINDVLSRH
NNKLSYDAMMEMTYMDK virhnnklsydammemtymdk VIN (1)
ETLRKYPPLPIIPRVCNKDYTI
PNTSTKLSRGTSVAIPVLAIHTDPEYYPNPEKFDPEHFSEENIKSRPGFTWLPFGDGPRICI (1) 27220
27307 GMRFGMMQSKVGLATILKNYKIKLNNKTEFPIKVDPKNFITTAKGGVWLDVEKLD* 27480
CYP6BQ10 Tribolium castaneum
GenEMBL XP_975564
87% to CYP6BQ11
MTLITNNITLDLVAIIATFLVGIIVYFKWQLSYWDRLGVPSLNPTLVFGDFKNYIFAKCSLGEQFKELYD
QFKSKGYKHGGVFVGPKPFYVPIDPEIVQHIMQKDFHHFMNHGNYFDENADPLSGHLFNLEDSKWKNMRV
KLTPTFTSGKIKMMFQTLADCTRGLDEIMYNSALNHAPADIKDILGRFTTDIIGSIAFGIECNSLKNPDA
EFRKYGRRVFEVGIIDRIKIICILALPDSVLRLLKLKFTKSDVENFFMNAIRDTVNYREKNNIYRKDFMH
LLLQLKNRGSVTDDEKVTDDKDNVKEKALTLNELSAQAFVFFLAGFETSSTTMTWALYELATNQDVQEKL
RNEINNVLSRHDNKLTYEAMMEMTYMEKVIHETLRKYPPLPILTRKCNKDYTIPNTCIKLRRGTTVAIPV
LGLHTDPEYYSNPEKFDPEHFSEENVKSRPGFTWLPFGDGPRICIGLRFGMLQSKVGLTAILKNYKVTLS
NKTKFPVTLDPKSFITTAKDGIWLDVKKLD
CYP6BQ11 Tribolium castaneum
GenEMBL XP_975563
87% to CYP6BQ10
MSLITDNLTFDLVAILATILVGIIVYFKWQLSYWDRLGVPSLNPVLFFGDIKDFILAKCTLGEQFKEFYG
KFKSKGYKHGGIFLGPKPFYVPIDPELVKHIMQKDFQHFVNHGNYFDEDADPLSGHLFNLEDAKWKNMRI
KLTPTFTSGKIKMMFQTLADCTRGLKEIMDHSALNHAPADIKDILGRFTTDIIGSVAFGIECNSLKDPDA
EFRKYGRKVFEVGFIDRLKTICILSLPHPVLRFFKLKFTKSDVEKFFMSAIRDTVNYREKNNIYRKDFMH
LLLQLKNRGFVADDGKVTDEKENVKEKALTLNELSAQAFVFFLAGFETSSTTMTWALYELATNQDVQEKL
RNEINNVLSRHDNKLTYEAMMEMTYMEKVIHETLRKYPPLPILTRKCNKDYTIPNTSIKLSRGTAVGIPV
LALHTDPEYYSNPEKFDPEHFSEENVKTRPGFTWLPFGDGPRVCIGLRFGMLQSKVGLTALLKNYKIKLS
KKTELPIKLDPKSFITTAKGGIWLDVEKLD
CYP6BQ12 Tribolium castaneum
GenEMBL XP_975562
65% to CYP6BQ6
MAIFTSSIFIDIITIITTVLALTIAFFKWKLTFWEKLGVPTLNPVLFFGDAKNILLGKRQVGVEFIDYYK
QFKPRGLKHGGVYLGPRPFWVITDPGLIKHILQIDFPHFINHGTYADEENDPLSAHLFSLEGTKWKNMRT
KMTPTFTSGKMKMMFQTLVDCTPGLKDIMDEHASKKKAVNIKNILERFTTDIIGSVGFGIECNSLKDPDS
LFPKYGKKVFDLTPAEQLKQSLLFFLPNPVLKAMKFRITNKDVEDFFMKTVRETVLYREKNNIYRKDFMH
LLLQLKNRGTVTDDEKIIDHSNQKQEPALTMNELTAQAFVFFLAGFETSSTTMTFALYELATNPDIQEKL
RNEICTVLEKHNNELTYNAIAEMTYMDQVLHETLRKYPPLPILQRQCNKDYIVPETNIRIPKGVDVAITI
LALHRDPEFYPNPEVFDPERFNEENKNARTPFTWLPFGDGPRVCIGLRFGMMQSKVGLTALLKDYRVTLN
KKTKVPLEMSKNSFIIAAEGGIWLDIEKINT
CYP6BQ13v1 Tribolium castaneum
GenEMBL XP_967146
54% to CYP6BQ4
MAILTYSWLLDIFGILTALIAVFIAWAQWSHTYWSRRNLIAPKTTFFLGNSKGIVTQKQSFGDFTVEMYE
YIRKHNKPHGGFYLTLMPNYMPVDPEIIKHIMLNDFDHFVDRGIYYNEEVDPLSAHLFSLDGAKWRNLRI
KLTPTFTSGKMKMMFDTLVKCSDQLLVEMNQTAGKAPVDAKNILARFTTDIIGSCAFGIECNSLKNPNDE
FTQYLKLFFVEGFWQNLNGIITFVAPELAKKLNMKVVNPVLSNFFMKVVEDTVNMRERNNIYRKDFMHLL
LQLKNRGELVDDDSILQNNTDAENKEVTLTLNELAAQAFVFFLAGYETSSTTMTFCLYELASNPEIQDKL
RAEINEVLQKHGKLTYDAIMEMRYMDKVVNETLRKYPPLPGLNRVCNKEYKVPGTDFVIEKGTKIWIPVL
GLHRDPEYFPNPEKFDPERFTEENKRQRHPYTYLPFGEGPRICIGLRFGMMQTKVGLSVLLKNYKFSINS
KTKLPLQLDPKSFIMSTEGGIWLDYTRV
CYP6BQ13v2 Tribolium castaneum (red flour beetle)
No accession number
Xu Yongqiang
Submitted to nomenclature committee Sept. 14, 2008
98% to CYP6BQ13v1, 9 aa diffs, 53% to CYP6BQ4
CYP6BQ14P Tribolium castaneum
GenEMBL AAJJ01000098
70% to 6BQ11
Frameshift in last exon,
one stop codon, no start, possible pseudogene
ISLGTTAYLVVLELGIALLVIVISYLKWRMTYWQKLGVPTLNPAMLFGDTKKMFLGECTF
GEQFLDIYNKFKARGVKHGGVYLGIKPFYLPLEPELVKHIMQNDFEHFVNHGLYMDKEND
PLSGHLFNLEDEKWKNMRNKLTPTFTSGKLKMMFQTLANCTVGLQTIMDDADTNHTPLDI
KDILGRFTTDIIGSVAFGLECNSLKDPDALFRKYGRKVFEMDIWERLKMFTQFVLSHRVL
RAIKFKV*KNDVERFFMKVIKDTVEYREKNNVSRKDFMHLLLQLKNRGSVTDDDKVTDDH
GKAQEKALTLNELSAQAFVFFIAGFETSSTTMTFALFELSTNPHIQDKLREEINQVLEKY
DDKLTYDAMMELTYMEKVIN (1)
ETLRKYPPAPVLFRRCNKDYKVPNTSIIIQKGIDVAIPVLGLHTDP
DYYPNPEDFDPERFSEDNKNKRPGFTWLPFGEGPRVCI (1)
GLRFGVLQTKVGLTALLKNYRVKLSPKTKMPLKMDKT
LLTSAEGGIWLDMEKLN
CYP6BQ15 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-8
56% to CYP6BQ6 Tribolium castaneum
48% to CYP6BW2
65% to short fragment CYP6BU1 Leptinotarsa decemlineata DQ631653
CYP6BQ16 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-18
50% to CYP6BQ10 Tribolium castaneum, 81% to CYP6BQ17
CYP6BQ17 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-19
47% to CY6BQ11 Tribolium castaneum, 81% to CYP6BQ16
68% to CYP6BQ18, 56% to CYP6BQ15
CYP6BQ18v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
96% to CYP6BQ18v2 possible variant of CYP6BQ18v2
2 aa diffs in 51 aa overlap
CYP6BQ18v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-17
51% to CY6BQ11 Tribolium castaneum
93% to CYP6BQ19
70% to CYP6BQ16, 68% to CYP6BQ17, 58% to CYP6BQ15
CYP6BQ19 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-20
62% to CYP6BQ2 Tribolium castaneum, 93% to CYP6BQ18
CYP6BQ20 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-11
55% to CYP6BQ10 Tribolium castaneum
57% to CYP6BQ15
CYP6BQ21 Dastarcus helophorides (parasitoid beetle)
KC683903
Haidong Wang
Submitted to nomenclature committee on Dec. 13, 2012
53% to CYP6BQ5 Tribolium. Top 14 hits are all CYP6BQ
CYP6BQ22 Dastarcus helophorides (parasitoid beetle)
KC683904
Haidong Wang
Submitted to nomenclature committee on Dec. 13, 2012
61% to CYP6BQ13v1 Tribolium
CYP6BQ23 Meligethes aeneus (pollen beetle)
No accession number
Christoph Zimmer
Submitted to nomenclature committee Nov. 27, 2011
61% to CYP6BQ19
CYP6BQ24 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
96% to CYP6BQ17 possible variant of CYP6BQ17
CYP6BQ25 Meligethes aeneus (pollen beetle)
No accession number
Christoph Zimmer
Submitted to nomenclature committee July 13, 2012
86% to CYP6BQ23 Meligethes aeneus (pollen beetle)
CYP6BQ? Or CYP6BU? Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-3
72% to CYP6BU1 Leptinotarsa decemlineata C-term
69% to CYP6BQ15
too short to name yet.
CYP6BR1 Tribolium castaneum
GenEMBL XP_969875
59% to 6BR2
MNIPSPYFEILGTVLALLVAIIFYYHHAFQFWARKNIPFIPPRFPLGNTNVVLPRGLTIGLLSKTFYDYF
KQRGHKIGGVFLVTEPNLMILDPDYIKNILLKDFHHFVDRGFYFNEKTDPISANLFTIDGDQWRNLRTKL
TPTFTSSKMKIMFQTVKNCCNNMLEAIASNTDLDKDLKEFLGRYTVDVVGSCAFGIECNSFKHPDAEFRK
MGLRAFHFSFLRSIRAFFIAYLPKLSRQMGLPSNNKDIREFFYKVVMETIQKREETQIKRNDFLQILMDL
RKTEILSLDEVAAQVFLFFTAGFETSSSTMAMCLYEIAKEPEYQEKLRQEICEITNGEITYENLFEMKYL
DQVFSETLRKYPPGQTLNRRCVKDYTLPGTSTIIEKGTPILISAIGVHRDPEYYPDPEKFDPERFSEENK
KLRHPFVYLPFGDGPRNCIGMRFGTMQSKLGIASVVKNFKVSVSPITKRVELDPNTFLLNTIDKIYFRVE
KIVK
CYP6BR2 Tribolium castaneum
GenEMBL XP_969813
59% to 6BR1
MGLFLEDFWTEVFFLLTTLAILVLSYFHNAYKYWEKRGVPTIKPTFPLGNGDTLLPEGFSVGMLSRKFYE
ELKKRGEKFGGVYLVTQPNLVLVDPEYVKDILATDFQYFVDRGFYFNEKTDPLSAHLFALDGTSWRNLRI
KLSPTFSSGKMKMMFKTVLECCGYMRDYIEDILDKDLDIKEIFSRYTTDVIGSCAFGIECNSFKYPDAEF
RKMGKKVFSFGLWRSICSFCIIYFPNLSYHLGVPTNEKDVQNFFRGIVAESVNTRKEQNIKRNDFLQLLI
DLKDHSALSLNEMAAQVFLFFAAGFESSSTTMTFVLYELAKHPDIQQELRNEIRKTLDKHQGQLTYEAVM
EMKYLQQVIDETLRLYPPLATLNRRCIKDYTLRNTGIKIEKGTSVIIPSLGLHMDPELYPDPEIFNPDNF
SEENKKKRPSFVHLPFGDGPRNCIGLRFALMQSKCGIATVVNNFRFSLSPATKPLRLNPNSFVLNTYDKI
YLRAERLAM
CYP6BR3 Tribolium castaneum
GenEMBL XP_969746, AAJJ01000871.1
59% to 6BR2
gene model is too long, revised
MSVFTEFWPQILVFLALFLLVLVNYFNYCYRYWSKKGVATIKPRFPLGNTNIILPQGLSIGILSKQFYDE
FKAKGHKFGGVYLVTEPNLLIVDPEYVKDIMSKDFQHFVDRGFYYNKEKDVLSAHLFAIDGSDWRNLRIK
LTPTFTSGKMKMMFEAVVQCSKHMIENLDKNLGSDIEIKEVLGRFTTDVIGTCAFGIECNSFKYPDAEFR
MMGKKIFEYDLWKSVKAFFAVNVPKVALQLGLTSTPDDVIDFFTRIVADAVKMRESNNIRRNDFLQILID
LKNTTSLTLDEMSAQVFLFFVAGFETSSTTMTFALYELARNEKMQEKLRFEICQVLDKTGGQITYESLIE
MKYLQQVID (1)
38219 ETLRMYPPLPTLNRRCTKDYVLRDTNIIIEKDTPILISALGLHMDPEFFPKPEKFDPERFT
EEKKKERHPFVHLPFGDGPRNCI (1) 38470
38524 GLRFGVMQSKIGIITIIKNFKLTVSSNMKPVQFNPYVFLLNINDKVLLQVGKL* 38685
CYP6BS1 Tribolium castaneum
GenEMBL XP_974742
47% to 6BQ13
MESALMEAGIIFLTIVSFVYLYFKHAYTYWKARNVPQLSPTFPFGDMASVIFRRHNMGDKIKEIYDETKA
RGHKYVGLYFFSRKAFLPIDPVLIKKILAPDFQHFHDRGIYYDEENDPISAHLFSLAGPKWKNLRARLTP
AYSPGKLKFMFDTVLACGEEMADILKEIAKREGKVEIKEILARYSTDVIGCCAFGIDCNSMRNPTAEFRL
MGRRAFTQTIGDVLKMIVIRSFPRLAKLLGFGVFSPTVTGFFQRVVNETIRYREENNVTRNDFMQLLIQL
KNKGKLEGDGEEKDGAPAVGTSLTLDEAAAQAFIFFLAGFETTSTTISFALFEMARNESIRTKARTEINK
VLGKHGGKLTYEATMEMEYLDTVISETLRKYPPAPVFLRKCTKTYRVPDTDVIIEEGLSVLIPAYGLHRD
PEYFPDPETFDPDRFNEDNRSKIWDYTYIPFGDGPRICIGMRFAMIQIKIALALILKSFEFPLSEKTILP
MKMENSGIILAPIGGIWLNLIPLE
CYP6BS2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
68% to Tribolium CYP6BS1 XM_969649.1
44% to CYP6AM1 Hodotermopsis sjostedti
43% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
clone name DPO024_H01
CYP6BT1 Tribolium castaneum
GenEMBL XP_969982, AAJJ01005307.1
45% to 6BK11
missing C-term runs off the end of AAJJ01005307.1
MLLLAESLITLVLLLIAYYKFSFQYWKRQNVPFIQPSIPWGNYPSALKRQDNFGELVVRMYHQMKKQGHK
YFGIYLFFQPCFVPTDPKFIKLILAKDFQHFNFRNFYYNEKDDPISAHLLSLNGEKWKRLRSKLTPTFTA
GKIKMVFKIFVECGKIIEHTLEHHAQNRTSFDVKEMFSSYSTDVIVNCAFGVEVDRLKKTEFKNYSQKAL
DFNTRRCIVMYLGAVFPKLCRKLGFRQIAKSAGDFFINIVRNTVEFREKTNTIRNDFLQLLINLKNDESD
DWGQFSIEEVAAQCFIFFLAGFETSATTMSFALYEIAANPHVYEQIMDEMRRVLDKYNGEMCHDAIKEMT
YLGQVVDETLRIHSPAYAVSRTCTQDYHVPETNIVLKKGFQVLIPIRGIHSDPEFYPEPEKFKPERFHPD
NRQNIEPYSYLPFGEGPRICIG 48
CYP6BU1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P6AA56104
65 amino acids from heme to end
48% to 6BJ1, 54% to 6BQ6 = XP_975569
CYP6BV1 Ips pini (pine engraver, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
41% to Cytochrome P450 6BQ1 [Tribolium castaneum]
clone name EST 24D01
CYP6BW1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
48% to Cytochrome P450 6BQ7 [Tribolium castaneum]
clone name EST MPB3B10
CYP6BW1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
100% to CYP6BW1 of Sandstrom
clone name DPO079_G21
CYP6BW2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on August 28, 2006
Full length sequence
65% to 6BW1
clone name #2, EST DPG14E01
CYP6BW2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
100% to the Sandstrom sequence
clone name DPO1127_B15
CYP6BW3 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
96% to CYP6BW1 Dendroctonus ponderosae
clone name DPO049_N22
CYP6BW4 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
96% to CYP6BW2
clone name DPO0410_N13
CYP6BW5v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH3-1
92% to CYP6BW3 Dendroctonus ponderosae
99% to CYP6BW5v2
CYP6BW5v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH3-2
92% to CYP6BW3 Dendroctonus ponderosae
99% to CYP6BW5v1
CYP6BW5v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6I-1
98% to CYP6BW5v2
CYP6BW5v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6I-2
98% to CYP6BW5v2
CYP6BW6 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
57% to CYP6BW1 Dendroctonus ponderosae
CYP6BX1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Missing some 5' sequence
47% to Cytochrome P450 6BQ12 [Tribolium castaneum]
clone name EST MPB1F02
CYP6BX1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
99% to CYP6BX1 Dendroctonus ponderosae
only 2 aa diffs at N-term, same gene
clone name DPO095_N14
CYP6BY1 Aedes aegypti (yellow fever mosquito)
CYP6BY2 Culex pipiens
CYP6BY3 Culex pipiens
CYP6BY4 Culex pipiens
CYP6BY5 Culex pipiens
CYP6BY6 Culex pipiens
CYP6BY7 Culex pipiens
CYP6BZ1 Aedes aegypti (yellow fever mosquito)
CYP6BZ2 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 32
50% to 6P4 Anoph., 64% to 6BZ1 Aedes
CYP6BZ2 Culex pipiens
CYP6CA1 Aedes aegypti (yellow fever mosquito)
CYP6CB1 Aedes aegypti (yellow fever mosquito)
CYP6CB2 Aedes aegypti (yellow fever mosquito)
CYP6CC1v1 Aedes aegypti (yellow fever mosquito)
CYP6CC1v2 Aedes aegypti (yellow fever mosquito)
CYP6CC2 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 35
53% to CYP6CC1 Aedes, 44% to 6AD1 Anoph.
CYP6CC2 Culex pipiens
CYP6CD1 Aedes aegypti (yellow fever mosquito)
CYP6CD2 Culex pipiens
CYP6CD3 Culex pipiens
CYP6CE1v1 Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
EF421245.1
Jiang Hongbo
Submitted to nomenclature committee on Jan. 31, 2007
48% to 6AM1
The psocid Liposcelis bostrychophila is often found infesting
flour in households.
CYP6CE1v2 Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
EU266572
1 aa diff to CYP6CE1v1, DDVP resistant strain
CYP6CE1v3 Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
EU266573
6 aa diffs to CYP6CE1v1, phosphine resistant strain
CYP6CE2 Liposcelis bostrychophila (a psocid, booklouse, parthenogenetic)
No accession number
Jiang Hongbo
Submitted to nomenclature committee on April 7, 2007
74% to 6CE1
The psocid Liposcelis bostrychophila is often found infesting
flour in households.
CYP6CF1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-3, 40% to CYP6N5
Pediculus genome site
CYP6CG1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-6, 44% to 6CE1 psocid, Liposcelis bostrychophila,
55% to CYP6CG2
Pediculus genome site
CYP6CG2 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-9i, 44% to 6CE1 psocid, Liposcelis bostrychophila,
55% to CYP6CG1, incomplete, missing N-term and last exon on C-term
Ph6-4f probably the C-term to CYP6CG2
54% to 6CE1 psocid, Liposcelis bostrychophila, 91% to 6CG3
Pediculus genome site
CYP6CG3 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-10i, Ph6-5f these probably join together
90% to louse EST CB887363,
Pediculus genome site
CYP6CG4 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-7,
53% to 6CE1 psocid, Liposcelis bostrychophila, 54% to 6CG1
Pediculus genome site
CYP6CH1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-8
39% to 6CE1 psocid, Liposcelis bostrychophila,
40% to 6BK4 Tc, 60% to 6CH2
Pediculus genome site
CYP6CH2 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-11
45% to 6CE1 psocid, Liposcelis bostrychophila, 60% to 6CH1
Pediculus genome site
CYP6CJ1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph345
47% to CYP6K1 Blatella germanica, 45% to 6CG2
Pediculus genome site
CYP6CK1 Philotrypesis sp1 (Hymenoptera: Chalcidoidea: Agaonidae)
non-pollinating fig wasp
No accession number
Liu Ying
Submitted to nomenclature committee Aug. 4, 2007
48% to CYP6BK5 Tribolium, 49% to CYP345B1 Tribolium
49% to CYP345A2 Tribolium, 47% to CYP6AS8 Apis
partial seq from I-helix to heme. Name may need revision later.
CYP6CK2P Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK6 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK7 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK8 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK9P Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK10 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK11 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK11-de3b6b Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK12 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CK13 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CL1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP6CM1v1 Bemisia tabaci (whitefly)
GQ214539
Shai Morin
Submitted to nomenclature committee Dec. 3, 2007
36% to many CYP6 subfamily sequences as in CYP6AM1
CYP4CM1v2 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
2 aa diffs to CYP6CM1v1
CYP6CM2 Trialeurodes vaporariourum (whitefly)
CYP6CM3 Trialeurodes vaporariourum (whitefly)
CYP6CM4 Trialeurodes vaporariourum (whitefly)
CYP6CN1 Plutella xylostella (L.) (diamondback moth, Lepidoptera)
GenEMBL EU189053.1 (incorrectly named CYP6B38),
GenPept ABW34440 (incorrectly named CYP6B43)
Jihyeong Baek
submitted to nomenclature committee Dec. 3, 2007
48-50% to CYP6Bs, 50% to CYP6B2
CYP6CN1 Plutella xylostella
Gene number CCG008489.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Complete, 97% to CYP6CN1, 8 aa diffs, 4 on the ends
CYP6CP1 Culex pipiens
CYP6CQ1 Culex pipiens
CYP6CQ2 Culex pipiens
CYP6CR1 Dendroctonus ponderosae (mountain pine beetle)
No accession number
Claus Tittiger
submitted to nomenclature committee Feb. 17, 2009
39% to 6BQ2, 41% to CYP6BQ7 Tribolium
note the names CYP6CR1 and CYP6CS1 have been swapped
to correct a bookkeeping error on my part
CYP6CR1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
100% to the Tittiger sequence
clone name DPO076_J20
CYP6CR2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
71% to CYP6CR1 Dendroctonus ponderosae (mountain pine beetle)
40% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
clone name DPO023_A01
CYP6CR3 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
84% to CYP6CR1 Dendroctonus ponderosae, 93% to CYP6CR4
CYP6CR4 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
82% to CYP6CR1 Dendroctonus ponderosae, 93% to CYP6CR3
CYP6CS1 Nilaparvata lugens, Homoptera: Delphacidae (brown planthopper)
FM994118
Zhifan Yang
submitted to nomenclature committee Jan. 20, 2009
~40% to 6F1
note the names CYP6CR1 and CYP6CS1 have been swapped
to correct a bookkeeping error on my part
CYP6CS2.a Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
N-term, 74% to CYP6CS1 Nilaparvata lugens
CYP6CS2.b Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
mid region, 82% to CYP6CS1 Nilaparvata lugens
CYP6CS2.c Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
C-term, 87% to CYP6CS1 Nilaparvata lugens
CYP6CT1 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-6
37% to CYP6BK4 Tribolium
CYP6CT1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
64% to CYP6CT1 Zygaena filipendulae
renamed as an ortholog, formerly CYP6CT2
CYP6CT1 Plutella xylostella
Gene number CCG013017.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Complete, 56% to CYP6CT1 Zygaena filipendulae
renamed as an ortholog, formerly CYP6CT3
CYP6CT1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
renamed as an ortholog, formerly CYP6CT4
CYP6CT1 Helicoverpa armigera (cotton bollworm)
CYP6CT1 Chilo suppressalis (striped rice stem borer)
CYP6CU1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP6CV1 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
submitted to nomenclature committee June 13, 2009
41% to CYP6B8v1 Helicoverpa zea
37% to CYP6AE28 Cnaphalocrocis medinalis
CYP6CV2 Plutella xylostella (L.) (diamondback moth)
No accession number
Selina Zhang
submitted to nomenclature committee Nov. 10, 2010
52% to CYP6CV1
CYP6CV2 Plutella xylostella
Gene number CCG002723.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Complete, 99% to CYP6CV2 3 aa diffs
CYP6CW1 Nilaparvata lugens, Homoptera: Delphacidae (brown planthopper)
No accession number
Zhifan Yang
submitted to nomenclature committee June 13, 2009
35% to CYP6N1
CYP6CW2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 76% to CYP6CW1 Nilaparvata lugens
CYP6CW3 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
mid region, 71% to CYP6CW1 Nilaparvata lugens mid region
CYP6CX1v1 Bemisia tabaci (whitefly)
No accession number
Lin Zheng and Gang Wu
Submitted to nomenclature committee June 10, 2009
Resistant strain, 2 amino acid differences to the susceptible strain
49% to CYP6CM1 Bemisia tabaci
CYP6CX1v2 Bemisia tabaci (whitefly)
No accession number
Lin Zheng and Gang Wu
Submitted to nomenclature committee June 10, 2009
Susceptible strain
49% to CYP6CM1 Bemisia tabaci
CYP4CX1v3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
3 aa diffs to CYP6CX1v2
CYP4CX2 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
CYP4CX3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
CYP4CX4 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
CYP4CX5 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
CYP6CY1 Acyrthosiphon pisum (pea aphid)
LOC100159226.pro SCAFFOLD10025:26656..31321 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
82% to LOC100163313.pro (adjacent),
77% to LOC100168115.pro (2 genes away)
CYP3 clan
MFTASWWINVITPCTIIVTITYYFCVSTFKKWEKLNVPYIKPIPLFGNFLNVALGKNHPLEFYNKIYHEFAGQKYAGVFQMRTPYLMVRDPEIINDVMIKNFSSFPDRGIYSDFVAEPLTNNLLLMENPQWKIIRNKLTPAFTAGKLKTMYDQIKECGDELMKNIDIDLNRTSNEIEVKDIMGKYSTDVIGTCAFGLKLNAINDDESPFRKYGKLIFKPSLRVLMRELCVMITPALLKVVRLKKFPTAATDFFHAAFNETMTYRLENNIVRNDFVHYLMQARNDLVLNTDLPKHEKFAESQIVANAFVLFAAGFETVSSAISYCLYELALNKSIQDRVRKEIQLQLSKNNGQINHELLIDLNYLDMVIAETLRKYPPLVALFRKASQTYRVPNSSLIIEKGQKIIIPIYAIHYDNKYYSDPEKFIPERFSAEEKAKRPSGVYLPFGDGPRICIDSEWLRNVLMLQ
CYP6CY2 Acyrthosiphon pisum (pea aphid)
LOC100163313.pro SCAFFOLD10025:31376..37086 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MFTANWWINFITPCTIIVTIAYYFCVSTFKKWEKLNVPYIKPIPLFGNLLNVAVGKDHPLDFYNKIYHKFAAHKYAGVFQMRTPYLMVRDPEIINDMLIKDFSSFPDRGIYSDFVAEPFSNHLFFMENPQWKIIRNKLTPAFTSGKLKMMYDQIKECGDELMKTIDIELIKNDDEIEVRDIIGKYSTDVIGTCAFGLKLNAIKDDESPFRKHGKTLFEPSLRALFKELCLMIAPALLKVIKVKDFPTDATDFLHTVFKETITYRQKNKIVRNDIFQCLIQVRNDLVLNADLSKNEKFTETQIVANAFAMFAAGFETVSSAISYCLYELALNKSIQDRVREDIELKLSNNDGQINHELLIDLNYLDMVIAETLRKYPPVVALFRKASQTYRVPNDSLIIEKGQKIIIPIYALHYDSKYYTDPEKFIPERFSAEEKAKRPSGIHLPFGDGPRICIGKRFAEMEMKLAFVEILTKFEVFPCEKTEIPLKYSNKVFTLMPKHGIWLRFKRIN
CYP6CY3 Acyrthosiphon pisum (pea aphid)
LOC100168115.pro SCAFFOLD10025:41696..46319 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
37% to CYP6A14, 38% to CYP6Y1, 39% to CYP6AQ1 bee
42% to CYP6AX1
CYP3 clan
MAYDLNEIKIKLNYVNIINVIIVVLYHYLFKIRFREKKYAEKYPLIEFDTKRENSVDSCVFCVGTLFNIQNCVNYRKGHMYPSSSSATDWWIYIVTPCLVAVTITYYFCISTFNKWEKLNVPYIKPIPLFGNFLKVALAKDHPLEFYDKIYYKFSGLKYGGLFQMRTPYLMVRDPEIINNMLIKDFSSFPNRGIYSDLAANPLSDNLFFMENPRWKTIRSKLTPAFTSGKLKIMYDQIKECGDKLMKNIDNDLKGKNDEIEVRDIMGKYSTDVIGTCAFGLKLNSISDDESPFRKYGKSIFIPSLRTLFRELCLMVSPALLKVVRVKDFPTDATAFFNAAFKETITYRLENKIVRNDFVNCLMQARNDLTLNTNLPKHERFSESQIVANAFVMFAAGFETTSTTLSYCLYELALNIHIQDKVRQEIQLKLSKSDGQIDNEFLMGLNYLDMVIAETLRKYPPLIALFRKASQTYRLPDNLILEKGQKIVIPIYSIHFDSKYFEDPLKFNPERFSSEERAKRPNCVYLPFGDGPRTCIGKRFAELEMKLALVEMLTKFEVLPCGKTEVPLKYSNKALTLMPKHGIWLRFKKIV
CYP6CY3 Myzus persicae (green peach aphid)
no accession number
Chris Bass
submitted to nomenclature committee March 4, 2010
88% to CYP6CY3, next best match is 79% to CYP6CY4
this is the apparent ortholog of CYP6CY3 of pea aphid
CYP6CY4 Acyrthosiphon pisum (pea aphid)
LOC100164042.pro SCAFFOLD10025:137606..141395 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
87% to LOC100167264.pro, 85% to LOC100163313.pro
80% to LOC100168115.pro 90kb downstream of LOC100168115.pro
CYP3 clan
MFTANWWINVITPCTIIVTIAYYFCVSTFKRWEKLNVPYIKPIPLFGNFLNIALGKDHPLEFYNKIYYEFAGRKYGGLFQMRTPYLMVRDPEIINDVMIKDFSSFPDRGIYSDFTANPLSNNLFFMENPQWKTIRNKLSPAFTSGKLKTMYDQIKKCGDELMKNIDIDLNKNGNEIEVRDILGKYSTDVIGTCAFGLKLNAISDDESPFRKYGKSIFTPSLRMLFRELCLMITPALLKVIRVKDFPTAATDFFHAAFKETMTYRIENKIVRNDFVHCLMQARNDLVLNTDLPKHEKFTETQIVANAFVMFAAGFETVSTTVSYSLYELALDKSIQDRAREEIQLKLSKNDGQINHEFLMDLNYLDMVIAETLRKYPPLVALFRKASQTYRIPNDSLIIEKGQKIIIPIYAIHYDTKYYPEPEKFIPERFSVEEKAKRPSGIYLPFGDGPRMCIGKRFAEMEMKLAFVEILTKFEVFPCEKTEVPLKYSNKVLTLMPKHGIWLRFNRIN
CYP6CY5 Acyrthosiphon pisum (pea aphid)
LOC100167264.pro SCAFFOLD13514:28216..31057 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MFTANWWINVITPCTIIVTIAYYFCVSTFKKWEKLNVPYIKPIPLFGNFLDIALGKAHPLEFYGKIYNEFAGRKYGGLYQMRTPYLMVRDPEIINDMLIKDFSSFPDRGIYSDFVANPLSNGLFFMENPQWKIIRNKLTPAFTSGKLKTMYDQIKECGDELMKTIDMDLIKNGKEIEVRDIMGKYSTDVIGTCAFGLKLNAINDDESPFRKHGKSIFTPSLRSLFRELCLMVTPALLKVVRVKDFPTDATDFFHAVFKETITYRLENKIVRNDFVQCLIQARNDLVLNADLPNHDFVLEKFTESQIVANAFGMFAAGFETVSSTISYCLYELALNKSIQDRLRKEIQLKLSKNDGQINPEFLMDLNYLDMVIAETLRKYPPLVALFRKASQKYRLPNDSLIIEKGQKIIIPIYALHYDNKYFTDPENFIPERFSAEEKAKRPNGIYLPFGDGPRICIGKRFAEMEMKLAFVEMLTKFEVFPCDKTDIPLKYSNNVITLVPKHGIWLTFKRIN
CYP6CY6 Acyrthosiphon pisum (pea aphid)
LOC100165240.pro SCAFFOLD13514:36706..45131 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
downstream of LOC100167264.pro
CYP3 clan
MFTDNWWIYVITPCTIIVTIVYYFCVSTFKKWENLNVPYIKPVPLFGNFLNVALGKEHHIDFYNKFYHKFAGHKYAGVFQMRLPILMIIDPEIINDVLIKDFSSFPNRGFSVDFKANPLSNNLFLMENPQWKIIRNKLTPAFTSGKLKVMYDQIKECGEELMKNIDIDLKKSGDEIEVRDIMGKYSTDVIGTCAFGLKLDAINDDESPFRKHGKSIFAPSLRQLFREMCMLISPVLVKVVRVKDFPKDATDFFHAAFKETMKYRHENKIVRNDLVHCLMQARNDLVLNTDLPKHEIVLEKFTESQIVANAFIMFAAGFETVSSAISYCLYELALNKSIQDRVREEIQLKLSKNDGQINHEFLMELHYLDMVLAETLRKYPPLVFLMRKALQTYRLPNDSLTIEKDQKVIIPVYAIHHDSKYYPEPENFIPERFSTEEKAKRPNGTYMPFGDGPRICIGKRFAEVEMKLAMVEMLTKFEVFPCEKTEVPLKYSHKTITLMPKHGIWLKFKKIN
CYP6CY7 Acyrthosiphon pisum (pea aphid)
LOC100160895.pro SCAFFOLD17283:187176..190201 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MIDVISCSIIGLLSSVYILYATVFLSIAYYLCTSTHDKWRKLNVPYTKPLPLFGNSMNLVLAREHPMDFFTGLYNRFPDEKLCGFYQMTTPFLMIRDPKLINNIMVRDFSYFTDHGFDTDPSVNILANSLFMLNGDRWRTMRQKLSPGFTSGKLKDTHDQIKECTDQLINIVDDNLKVSDHFEIRELVGNFSTDVIGMSAFGLKLDTIRNGNLDFRKFGKKIFQSDFKQLFVQAMMLFCPKLVTILKLKQFPDDAADFYGSMFRDVLEYRDRNNVIRNDVTQTLIQAKKDLVTNNDGDDSTSKNKWTEMDIVGNAILMFVAGAETVSITICFCLYQLALNKDIQDKLREEIVTTNAKHGGQLNNDFLTNLHYMNMVLEEVSRMYSITMILFRQATKNYEVPGQSLVIEKGQKIIIPAYCIHNDPKYYPNPGTFDPERFSTEEKAKRLNGTYIPFGDGPRLCIGKRFAELEMKLVLSKILLKYEVLPCEKTEVPINIRGAGSIVNPKNGVWLSFKPIVAN
CYP6CY8 Acyrthosiphon pisum (pea aphid)
LOC100159248 SCAFFOLD5532:14697..15575 (- strand)
and SCAFFOLD5532:7975..9925 (- strand) (seq gap in middle of gene
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MLIFANFWMDFIILVTVLFSIIYYYCTSTFNVWKKLNVPYVRPIPLFGNYLKVALGIENPMETYKNIYYELAGFQYGGMFQMRTPYLMIRDPEIVNNILIKDFSYFTDRGIHVDFKAEPLSEVLFLMENPRWKKLRSKLSPAFTSGKLKQMYSQIEKCGQDMIINIFAELKKNPNEIDIRDILAKYSIDVIGSCAFGLALNVASDDTSLFRSYGKTAFSETLRKYPLLFALFRVATKTYRVPNDSLIIEKGQKIIIPTFSLHFDPRYFSDPEVFNPERFSTKEKAMRPNGVYLPFGDGPRLCIGKRFAEMEMKLALVEILSKFEVEPCEKTEIPIQFSKLSVVVIPKDEKILLKLNPLSE
CYP6CY9 Acyrthosiphon pisum (pea aphid)
LOC100161627 SCAFFOLD1099:1136..6561 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MSASQLLVDLAAGWWTVAVLALLAATVYHFCTSTFGYWRDRGVPYVRPTVPLFGNIGGLALGVEHQARMFGRIYDGFRGQRYGGFFQMRTPHLMVCDPALVNRVLIGDFAHFTDHGMYTAGPDENPLANGLFNMNGAQWKIMRQKLSPVFTAGKLRHMRGQVTECSEQLMRNVAADVPAGGGQMEIRDVLGKYSTDVIGTCAFGLHLNAINDERSSFRKHGKAVFAPSFRVLLKELAWMVTPALRRALRIGDMPPDAAQFFTAAFTDTMKYREEHGIVRDDFMQSLIQARTDLVVNKTEPSVEFLETDIVANAFILFAAGFETVSTAMSFCLYELALKKPIQDKVREEMNTTKKKHNAEIDNDFLKDLHYLEMVLAETLRKYPPLLTLFREATQDYQVPDDTFVIEKGTKVLIPAYAIHHDYRYYPDPETFDPERFSPEEKAKRPNGTYMPFGDGPRLCIGKRFAEMEMKLALTELLTTYEVEPCEKTDIPMRFSKRSLIITPENGIWLKFKPIHTSK
CYP6CY10P Acyrthosiphon pisum (pea aphid)
LOC100159387 SCAFFOLD6634 coords:14145-18091 (- strand) pseudogene
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
upstream part not found in region up to next gene
47% to CYP6A13, 48% to CYP6AQ1 C-term only CYP3 clan
67% to LOC100168007.pro
CYP3 clan
MESQILSNAFGFFAAGFDTTSTSISYCLYELALKKNIQDRVREEIKLTKSKYNGVIDNEFLNDLHYLDMVIAESLRKYPLMFALFRVATKTYRVPNDSLIIEKGQKIIIPTFSLHYDPKYFSDPEVFNPERFSPKEKAMRPNGVYLPFGDGPRLCIGKRFAEMEMKLALVEILSKFEVEPSEKTMIPVQFSKLSVVVIPRDEKILLKLNPLSE
CYP6CY11P Acyrthosiphon pisum (pea aphid)
SCAFFOLD12002:AUG4_SCAFFOLD12002.g13.t1 pseudogene
SCAFFOLD12002:309999..313284 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
86% to LOC100163195.pro not in the submitted gene collection
CYP3 clan
MISCLIDFLLGTPAIAVTVLMAFVYYYTTNTYDKWLKLNLRYDPPWPLVGNTMKMVTLIE HQLATIDGIYKRLAGEKYCGFYQTKTPFLMIRDPELINNILIKDFLNFANRGFHKDPALN IIANGLFFMEGPKWDVMRQKLSSGFTSGKLKLAHNQIAECSDELMRFIAAKMKENDQIEVK
*TMSKYSTDVIGTCAFGLSL
CYP6CY12 Acyrthosiphon pisum (pea aphid)
LOC100163195.pro
SCAFFOLD12002:306085..309474 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
39% to CYP6AX1
CYP3 clan
MISCLIYVLFGTPAIAAVAVLAAILYYYTTNTYDKWLKLKVPHDPPWPLVGNTAKMMTLIEHQLTTIDGIYKRFSGEKYCGFYQMKTPFLMIRDPELINNILIKDFSNFADRGFHKDPALNIIANGLFFMEGPKWKMMRQKLSPGFTSGKLKLAHNQIAECSDELMRFIAAKMKENDQIEVK ETMSKYSTDVIGTCAFGLKLDTVKNEGSDFRLYGRKILKLSFRFLLAEMVSPKILKLLGVAEFPPDASAFYESAFKEVIRYREENGIVRHDVAQSLIEARKELVLDSTDENGFTEQHIIANAILMFLAGFETVSSTLSFCLYHLALNQDVQEKIRDEMNSKLKQHGKINNDFLVNLHYTDMVLAETERMYVVTNALFREAVKTYHVPGDTLVIEKGTKIMIPIYSIHHDPTYYPEPYIFDPQRFSPEEKAKRQSSTYLPFGDGPRFCIGKRFAELEMKMVLSQIITTFRILPCEKTEVPLKLQNGLPMMVAKNGIWLRFQSISE
CYP6CY13 Acyrthosiphon pisum (pea aphid)
LOC100167704.pro SCAFFOLD7563:47979..58025 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
only P450 on this 60 kb contig
CYP3 clan
MISWMFNCLIDSFTLICTTVIGLLFYYYSTSTYKKWRKANVPHTKPVPFFGNFFRSTLGFETINDTYHNIYKQFPDKKFCGFYQMRTPTLMIRDPELINNVLIKDFSHFTDHGLDMDPSVNFLASSLFFTRGQKWKIMRQKMSAGFTSGKLKLMHSQIKDCSKEMIDYIDRKSKTTDQFDMHDIMNKYATDVIGTCAFGLKLGSMKDEDNEFRKFTKLLFKPSFRLIFTNILSLISPKTSNILKIKTSSPEVMEYFTTSFQNVIEYREKNNMDRNDVAQTLMRARKELKFTEMDIISNAILMYLAGAEPVSDTLGFCLHELAINKHVQDKLRKHINTKRKEHGGEFTNDYLMDLHYADMVLTETLRKCNGTIVLFRKATKAYQVPDSSLVIEKGQQIIIPTYSIHHDPKYYTNPDVFDPERFSPEEKSKRPSSTELLFGDGPRFCIGKRLAELEMKLGLSEIISKFEILPCEKTENPVQLANAGGAIKPKNGIWLI
CYP6CY14 Acyrthosiphon pisum (pea aphid)
LOC100161480.pro SCAFFOLD8603:3827..8475 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MISYLTNLLFDYIFLSLIIVCTFLYYYTTSTYDTWRKLNVPFAKPVPFFGNIFKMFTGLERQVDAFGRIYQQFPDEKFCGFYQMSTPFLMLRDPELINTVIIKDFSYFTDHGIDMNPSVNVMARSLFFATGQKWKTMRQKLSPGFTSGKLKGTHEQIRECSDQLTNCIYEKSQKTDAIEVYELVGNTATDVIGTCAFGMKLDTINNDNSSFRQNVKKVFKPSGKVIFAQILGVLFPKIVKFLKLQTSPVDVDAVNFFHSVFGEVIEYRTKNDVVRNDLTQTLMKARQDLVVSSDYKGEEKYCELDIIANAMLLFTAGSETVTATASFCFYELALNKVIQDRLRDEIISSKIKHGGQLNNEFLEDLHYADMVLDXXIEKGQKILIPIYSIHHDPKYYPNPETFDPERFTAEEKSKRPNGTFLPFGDGPRHCIGKRFAELELKLILSKILTKFEISPCEKTEIPLQMNKERGITSPKNGIWLNFRPIVE
CYP6CY15 Acyrthosiphon pisum (pea aphid)
LOC100163900.pro SCAFFOLD5222 coords:2410-5346
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MYFLTDWLLDNFTYLSLIAVFTGFYYYSTSTYGKWQKLNIPYIPPVPLFGNAFRMVTKLECPMDMYDRLYKQFPDVKLLGFYQMTEPMLLIRDPELINAILIKDFPYFTDHGFVMDPSTTVMAKSLFFSNGQRWRTMRQKLSPGFTSGKLRDTYLAINECSNQMVSSIVEKLGKTDRLAIRSIISGFSNDVIGMCAFGIQLDSMNNEDSDFRRYSERIFEKTTKQIIVQAVTTIFPFVINLFKIQMFSAEATNFFRKVFADVINYREKNNIVRNDLTQTLLQARKELVLKENSTAEGIVFADQFTDDDIIGNAIVLFADGAETISSIVSFCLYELALNKEIQDKMRAEICSMKAKHDGQFNNDFLMDLRYTNMVLEETGRKYSIASILMREATKTYTLPDESFVIEKGQKLIIPMFSIHRDPKYYPDPLIFDPERFSKEQKSQRPNGIYMPFGDGPRMCMGKRFAELEMKLVLSNVLSKFEVLPCEETEIPLEITDETGVIAPKRDLVLKFRPIIED
CYP6CY16 Acyrthosiphon pisum (pea aphid)
LOC100162372 SCAFFOLD1019:69426..73624 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MISFMTDWLHDNVTCLSLIAVLASFYYYSTSTYGKWRILNIPYVPPVPLFGNTTRMMLRLEHPIDMFERFYNSFPDVKLFGFYQMRDPVLLVRDPELINAILVKDFSYFTDHGIDLDSSTSVLANSLFFANGQKWRTMRQKLSPGFTSGKLKDTHGQINECSDEMVSGIVESIKKKTDQIDVKTITGGFSTDVIGTCAFGMKLDTIKNDDSDFRRYVKIMFQSTPKQMIVQVLLMICPWVIKVLKINMFSVEATNFFHNVFTDVFKYREEHNVIRNDLTQTLMQARKELVLKENSSIEDKFTDADIIGNAILMFTAGSETISSMLSFCLYELALNIEIQDRLRSEICSMKAKHDGHLNNDYLMDLYYTNMVLEETARKYSIAFNLMRVATKTYTLPDESFVIEKGQKLIIPMFSIHRDPKYYPDPLRFDPERFSTEQKSQRPNGIYMPFGDGPRLCIGKRFAESEMKLVLSNVLSKFEVLPCEKTEIPVNIRSMSGFITPKNGIVLKFRPIVEH
CYP6CY17 Acyrthosiphon pisum (pea aphid)
LOC100164459mod.pro (N-term trimmed)
SCAFFOLD2510:85936..93942 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP3 clan
MNDIKLLNGLVSGAVDSPDLLSRIGFRIPDKYSNRKRPLPLNKPIMISFLIDCLVNNVTCLSLIVIFTGSFYYYSTSTYNKWRKLKIPYVPPVPLFGNTFRMLARLEHPIDTFDKIYNHFPDFKLFGFYQMREPMLLVRDPELINMILVKDFLYFTDHGVDIDPSMSTLAKSLFFANGQKWRTMRQKLSPGFTSGKLKGTYCQINECSDEMVSSIVEAIGKKTDRIELKTITGRFSTDVIATCAFGLKLDSIKNGDSEFRRYVKILFQTTTKQAIILILSLICPRVVKILRLQFFSLEATNFFSKVFADVIKYREDHNVSRNDITQTLIEARKELVLKEISTTEDKFTDDDIIGNAIFLFSAGSETISSLVCFCLYELALNKEIQDKLRAEIYSMKAKHNGKLNNDYLVDLRYTNMVLEETGRKYSIAFNITRVATKTYTLPDESFVIEKGQKLIIPMFNIHRDPKYYPDPLRFDPERFSMEQKSQRPNGTYIPFGDGPRLCIGKRFAEAEMKLVLSKVLSKFEVQPCEQTEIPLDIRSGSGLLSPKNGLVLKFKPIIEH
CYP6CY18 Acyrthosiphon pisum (pea aphid)
LOC100168007.pro SCAFFOLD1502:67256..70800 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
39% to CYP6AX1
73% to LOC100164042.pro
CYP3 clan
MHRTTLISLGGLFMHNINLLSNNIIVSVVKMSLYNLYLYCLYGCNVIYKLDKFSGITIYHNENPSSIQYRITNDIFTLYLMKIAEANAVLTLAYVKLVVFCVFLIMFSFIFIWWINIITPCLFIFTITYYFCTLTYSKWEKINVPYIQPIPLFGNFLDVALGMQHPIDFYRKIYYELAGYKYGGLFQMRTPYLMIRDPEIINNVLIKDFSNFPNRGIYSDFSANPLSNQLFFMENPQWKIIRKILSPAFTSGKLKLMYDQIKECGDELMKNIHKNLTKTDNKMEVRDILGKYSTDVIGTCIFGLKLNAVSDDNSTFRKYGKSLFLPSLRTHLRELSLMITPALLNILRFKDFPADATEFFHSAFHETITYREKNNIVRNDFVQTLIQARNDLVLNKNIPQRERFLESQIVANAFVMFAAGFETVSTAISFCLYELSFCLYELSLKKHIQDKVREEINLKLSKNNGLINNDLLIDLNYLDMVLAETLRKYPPTFALFRKASQTYHVPNDSLTIEKDQKVIIPIYSLHYDPKYFADPEVFDPERFSPEEKSKRISGTYLPFGDGPRICIGKRFAELEMKLALVEILTKFETEPCERTEVPIRFSKKALITMPENGIWLTFKKITNQ
CYP6CZ1 Acyrthosiphon pisum (pea aphid)
LOC100165972.pro SCAFFOLD1502:79066..88489 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
downstream of LOC100168007.pro, 46% to LOC100168007.pro
CYP3 clan
MFEFVYELFDLKMLLVTAFLGAIYVYSTWTHSHWSKLGISSPSAPVPLFGHAMPSMLGQMHFMDVLHNLYKELGDQRFGGIYTMRTPQLLVKDPELIGHILIKDFNNFTDRGLYAGTHTNPLNNNIFFTRGERWKTMRQKLSPTFTANKLKYMNEQVKECSDGLLSTIGKNLDDDAGRIEIREMMAKYSTDVIGSCAFGLKLDAINDPDSEFRKHGKTVFQPSLRSKIRVAVIFMQPSLLSIFRVHHYSHRTIRFFHDAFQQTIEYREKHNEDRKDFVQHLMKAREDLVLNPNLKPE
EKFTEMDIVANAYILFIAGFETVSTSMSFCMYELALRKDVQDKVRKEILEVKSKYNGQMNSECLNELHYMGMVIKETLRKYPPLVTLNRVVTKPYVIPGTQIKLKIGTKIVVPVHAIHYDPKYYSDPEAFEPDRFSDENIHNIQPNTYMPFGDGPRFCIGKRFAEFEMKMALSEVLTNYEVMACDKTQIPIKYVIGSFVNIPESVWLKFRKVNT
CYP6DA1 Acyrthosiphon pisum (pea aphid)
LOC100159636.pro SCAFFOLD17790 coords:18123-22112
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
41% to CYP6AX1
CYP3 clan
MSGVWSIPFVQLCAAAVLLVTFLGYMYLTYHYGKWTGLGVPHAAPSPPFGSLRDVVMGRVPLVDAIHSLYRRFDGQRYFGIYEGRQPLLVVCDPQLVHTIMVKDFRSFVDRNAGKVSFVHDKLFDHLVNLRGEQWKAIRAKLSPTFSAAKLKSMLGDINVCTARLIDNLNGQITKNSGIVDVSEASAQFTTDTIGSCAFGLDCNALSNPDSEFRRTGRAIFTPSLRSNLLNITRLVGFGRLLDVFRIRGMSGNIYDFFDNLLDTTMEQHKSGENTRNDFIALLVKLKDEEKQKEHGQKLFTDDILAANSFVFFVAGFETTASTISYCLYELAMNPEIQVKLRENIKKTLDANDGKLAYDTLKDMKYLDMVINETFRLHPPVPVLNRVCTQKYTITDSNITLNVGDKLIIPTYSLHHDSKYYSDPEIFDPERFTEENISSRPHGTFLPFGDGPRICIGLRFAMMEAKTGLAEILSKFEVSPCKETQTPIKIKPRSILLTPNESIRLSFKSIDQ
CYP6DA2 Acyrthosiphon pisum (pea aphid)
LOC100168454.pro SCAFFOLD17790:22986..29493 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
downstream of LOC100159636.pro
39% to CYP6AX1, 39% to CYP6a2
CYP3 clan
MICFSCWLEIVPIAAIASALLTYVYCTRYYGHWTALGVPHTKPAPLLGHFAGPTMGRESGTITVDTLYRRFVGHRYFGVYQLRHPMLVVRDPVLVHAVLATEFGSFHDRVMSRTSFEHDGLFNSLVNLRGDKWKAVRAKLSPTFTVAKLKAMFASLHVCTGQLTDKLLLLTSGGQGIVNVTDVSSKFTIDTIGRCAFGINCNTLFDSNTEFQRAGQAVFTPTLKSSVLNFMRLIDLGWLVDLFRLRSMPDLVYEFYLNLFQDTLELRKNEKEDRNDFVSILVKLRNDEKINNSRVELFTDDVLASNAFIFFAAGFETTASAMSYCLYELALNQDIQVELRKQIQHTLNENGGILTYDVLKDMKYLDMVLNETLRMHPPGPGLLRVCTKKFKIPDSDITLDTGMKVLIPTYSLHHDPAYYPNPELFDPLRFTEDNKALRPNGTFLPFGDGPRICIGLRFALMEAKTGLAEIISKFEIFPCKYTKIPIKLNPRSILLTPNEPISLLFKQIA
CYP6DB1 Acyrthosiphon pisum (pea aphid)
AUG5s6612g1t2 XR_045850
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
40% to CYP6K1
missing about 60 aa at N-term (added)
CYP3 clan
MISKEIIFVYTTCAIVVLFTAVYLYYRNIYSYWKKLGVYHLEPLFFFGNAKERVLFKKSFHEFHRD
MYFKFKGHRYAGYYLGRRASLVILDPEIIKCIMIKDFNHFTDRQTMRFRTSEYITEMLINLKGSKWKRMRGQLTPAFTSGKLRTMEHLVDVCCNNMSDFLNENIKSEQGYDLEMKDFFGKFTLDVIATCAFGVESNSLKDVNGGFASRVSKFASLSIMKRLTLYIVLLFMPGIARFVPLSFFNMEVIQFLANVIKEAKKCRKSTGQKRNDFLQLLLDSETDLDKNDKTKSKEDVLTEAQVVAQSVLFLIAGFETSSTLLTFTCYELAINQTIQDKLREEICSVLKRFNGKCTYEAMQEMPLLDMVLMETLRMHPPVAQLERVSTQDYTLPDSNLLLKKGMTVQIPVIGLHYDPEYYPDPYKFEPYRFSPEEKAKRSHYVFLPFGTGPRNCIGLRFALMSTKRGMVHLLKDFSIDLSKEMTVPYEYSKHSMLLKAKDGIRLSFNKLSA
CYP6DB2 Trialeurodes vaporariourum (whitefly)
CYP6DB3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
68% to CYP6DB2 Trialeurodes vaporariourum (whitefly)
CYP6DB4 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
77% to CYP6DB2 Trialeurodes vaporariourum (whitefly)
CYP6DB5 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf31
58% to CYP6DB2
CYP6DC1 Acyrthosiphon pisum (pea aphid)
AUG5s9515g6t1p
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
41% to CYP6AM1 Hodotermopsis sjostedti
CYP3 clan
MVFFDSSLLNLVAYGIVISTTFYFYLRYRYTFWQRQGCPVPLKPHIIYGHTKEVTKMKTWVGKHYANIYYNTDGYKFVGFYQFQKPKLMLRDLNIIKDVFTKEFSTFPNRGIVFDDKLEPLTGNLLTLEGHRWKVLRNKLTPAFTIGKIKNMIDLIDGRAQEMVRVLEKSAVIGEQVEFKELLARFSTDVISIVAFGFETNSLTNPDAEFRRVGRMLFSTSLETIIRNALNALAPSLIGLLKVRSIKKEYADFFYNVVNDTVKYREENGIQRNDFLDLLMKIKRGQNLASDEDNFKFTMDVLAAQCFVWFIGGYETSSVTLTFTFFELAQNLDVQMRAQDEIDSVLSKYDGKLTYEILQEMPYLDMIVSEALRKYPPVPNLTRKAVKPYKLPNSDFTLDKGLQVVIPVYGIHNDPEYWPEPEKFIPERFTEEEKRNRPQYAYLPFGAGPRLCIGMRFGMMQVKVALFRILSTYNISLSKSMKLPMKMNPKTIPANPDGGMFLHITKRKN
CYP6DD1 Acyrthosiphon pisum (pea aphid)
LOC100162594.pro SCAFFOLD16233:102870..132505 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
46% to CYP6AY1, 42% to CYP6M11
CYP3 clan
MFPAVVIIVACCTTVILFLYKYTTYTYKYWKSKSVTFATPVPLFGNIKDHVTLKMTQGECLKNIYNDFPREKFVGMYQLQTPTLLLRDPETIRLFLVKSFAHFTDRGFSYDGHREPLTKHLVNLEGDTWKILRQKLTPTFSSGKIKSMLGLLQGCGVQLIEYMDATIESGKTEFEIRDLTAKFTTDVIGTCAFGLECNSLKDSQSEFRRMGCAVLNSSASLALAKMVRVFFPKLFKALKLRTFPAEVQQFFMGIVKQTIDFRNTNRVRRNDFIQLLLEIKNQNHNQENAIKSIELTEELIAAQVFVFFLAGFETSSTTLSFCLHEMAVNQDIQNRVYDEINETANMYGLPFSYEAISSMNYLEQCLKETMRKYPPVQALARVCTKQFRVPGTDLDLDVGTAVLIPVYAIHHDPQYYPEPDTFNPDRFAKDGDGGGGDNGRPSGVFLPFGDGPRICIGMRFAMLEMKLALAQFLHRYLVTLSDKSCTRIEFEPASFLSCPKGGIWLNVNKRKA
CYP6DE1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
99% to EZ115020 Dendroctonus ponderosae 16-AUG-2009 Tittiger
84% to DPO047_M21
45% to CYP6BV1 Ips pini (pine engraver, bark beetle)
clone name DPO0814_E19
CYP6DE2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
84% to CYP6DE1
44% to CYP6BV1 Ips pini (pine engraver, bark beetle)
clone name DPO047_M21
CYP6DE3 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
81% to CYP6DE2
45% to CYP6BV1 Ips pini (pine engraver, bark beetle)
clone name DPO089_C09
CYP6DE4 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
67% to CYP6DE2
43% to CYP6BV1 Ips pini (pine engraver, bark beetle)
clone name DPO0910_C07
CYP6DF1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
45% to CYP6BW1 Dendroctonus ponderosae
clone name DPO074_P02
CYP6DG1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
47% to CYP6BR3
42% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
clone name DPO0310_A06
CYP6DG1v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH4-1
89% to CYP6DG1 Dendroctonus ponderosae (probable ortholog)
98% to CYP6DG1v2
CYP6DG1v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH4-2
89% to CYP6DG1 Dendroctonus ponderosae (probable ortholog)
98% to CYP6DG1v1
CYP6DG1v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6F-1
100% to CYP6DG1v4
99% to CYP6DG1v2
CYP6DG1v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6F-2
100% to CYP6DG1v3
99% to CYP6DG1v2
CYP4DG2 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
57% to CYP6DG1 Dendroctonus ponderosae
CYP6DH1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
97% to DPO123_O19
40% to CYP6BW1 Dendroctonus ponderosae
clone name DPO011_M04
CYP6DH2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
40% to CYP6BW1 Dendroctonus ponderosae
clone name DPO123_O19
CYP6DH3 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
68% to CYP6DH1 Dendroctonus ponderosae
Clone name DPO143_B19
CYP6DJ1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
99% to EZ115116.1 1 aa diff EZ115116 16-AUG-2009 Tittiger
84% to EZ116057.1 16-AUG-2009 Tittiger
43% to DPO0310_A06
39% to CYP6BJ1 Leptinotarsa decemlineata (Colorado potato beetle)
clone name DPO0411_I13
CYP6DJ1v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH1-1
90% to CYP6DJ1 Dendroctonus ponderosae (probable ortholog)
97% to CYP6DJ1v2
CYP6DJ1v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH1-2
90% to CYP6DJ1 Dendroctonus ponderosae (probable ortholog)
97% to CYP6DJ1v1
CYP6DJ1v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6H-1
99% to CYP6DJ1v4
97% to CYP6DJ1v2
CYP6DJ1v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6H-2
99% to CYP6DJ1v3
98% to CYP6DJ1v2
CYP6DJ2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
82% to CYP6DJ1 Dendroctonus ponderosae
clone name DPO1016_M18
CYP6DJ2v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH2-1
93% to CYP6DJ2 Dendroctonus ponderosae (probable ortholog)
99% to CYP6DJ2v2
CYP6DJ2v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP6RH2-2
93% to CYP6DJ2 Dendroctonus ponderosae (probable ortholog)
99% to CYP6DJ2v1
CYP6DJ2v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6G-1
99% to CYP6DJ2v1
98% to CYP6DJ2v4
CYP6DJ2v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP6G-2
98% to CYP6DJ2v1
93% to CYP6DJ2 DPO1016_M18
CYP6DK1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
99% to EZ115020 16-AUG-2009 Tittiger
39% to CYP6BW1 Dendroctonus ponderosae
clone name DPO0814_K02
CYP6DL1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig7818_21018 494aa (formerly 6DE1, but name conflict)
44% TO CYP6CY3, in the CYP3 clan
CYP6DL2 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig7817 395aa (formerly 6DE2, but name conflict)
40% to CYP6AX1, 87% to contig7818, in the CYP3 clan
CYP6DM1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig9338_22180 501aa (formerly 6DF1, but name conflict)
40% TO CYP6A2, 79% to contig22179, 51% to CYP6X1, in the CYP3 clan
CYP6DM2 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig22179 347aa (formerly 6DF2, but name conflict)
47% to CYP6X1 Lygus lineolaris, in the CYP3 clan
CYP6DN1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig20497 560aa (formerly 6DG1, but name conflict)
38% TO CYP6CE2 Liposcelis bostrychophila, 90% to contig22672,
62% to contig10526, 57% to contig10525, in the CYP3 clan
CYP6DN2 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig22672 511aa (formerly 6DG2, but name conflict)
35% to CYP6M11, in the CYP3 clan
CYP6DN3 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig10526 515aa (formerly 6DG3, but name conflict)
35% TO CYP6BQ13 Tribolium, in the CYP3 clan
CYP6DN4 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig10525 477aa (formerly 6DG4, but name conflict)
37% TO CYP6BQ13 Tribolium, in the CYP3 clan
CYP6DP1 Trialeurodes vaporariourum (whitefly)
CYP6DP2 Trialeurodes vaporariourum (whitefly)
CYP6DP3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
58% to CYP6DP1 Trialeurodes vaporariourum (whitefly)
CYP6DQ1 to CYP6DV3 Trialeurodes vaporariourum (whitefly)
CYP6DV4 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
59% to CYP6DV1 Trialeurodes vaporariourum (whitefly)
CYP6DV5 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
66% to CYP6DV4 Bemisia tabaci
CYP6DV6 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
58% to CYP6DV4 Bemisia tabaci
CYP6DW1 Trialeurodes vaporariourum (whitefly)
CYP6DW2 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
60% to CYP6DW1 Trialeurodes vaporariourum (whitefly)
CYP6DW3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
71% to CYP6DW2 Bemisia tabaci
CYP6DX1 Trialeurodes vaporariourum (whitefly)
CYP6DX2 Trialeurodes vaporariourum (whitefly)
CYP6DY1 Trialeurodes vaporariourum (whitefly)
CYP6DZ1 Trialeurodes vaporariourum (whitefly)
CYP6DZ2 Trialeurodes vaporariourum (whitefly)
CYP6DZ3 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
62% to CYP6DZ1 Trialeurodes vaporariourum (whitefly)
CYP6DZ4 Bemisia tabaci (sweet potato whitefly)
JN165274.1
Yidong Wu
Submitted to nomenclature committee March 2, 2011
60% to CYP6DZ1 Trialeurodes vaporariourum (whitefly)
CYP6DZ5 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
60% to CYP6DZ4 Bemisia tabaci
CYP6DZ6 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
84% to CYP6DZ4 Bemisia tabaci
CYP6DZ7 Bemisia tabaci (sweet potato whitefly)
No accession number
Xin Yang
Submitted to nomenclature committee May 23, 2012
96% to CYP6DZ6
CYP6EA1 Trialeurodes vaporariourum (whitefly)
CYP6EB1 Frankliniella occidentalis (western flower thrips)
EST part GQ290643
Dina Cifuentes Romo
Submitted to nomenclature committee Feb. 17, 2010
47% to CYP6EC1, 40% to CYP6N6
whole sequence known but confidential
CYP6EC1 Frankliniella occidentalis (western flower thrips)
EST part GQ290640
Dina Cifuentes Romo
Submitted to nomenclature committee Feb. 17, 2010
47% to CYP6EB1, 41% to CYP6AA5v1
whole sequence known but confidential
CYP6ED1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-1
40% to CYP6BK6 Tribolium castaneum
48% to CYP6EE1
43% to CYP6EF1
48% to CYP6BH1v1 in 64 aa from heme region to end
CYP6ED1v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
98% to CYP6ED1v1 (4 aa diffs)
CYP6ED2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-2
56% to CYP6F1 Culex pipiens (aa 299-399)
65% to CYP6ED1, 55% to CYP6EE1
CYP6EE1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-16
39% to CYP6BK2 Tribolium castaneum
48% to CYP6ED1
44% to CYP6EF1
43% to CYP6BH1v1 from heme to end
CYP6EE1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
100% to CYP6EE1v1
complete seq.
CYP6EE1v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
98% to CYP6EE1v1 (5 aa diffs)
CYP6EF1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-5
52% to CYP6BR2 Tribolium castaneum
48% to CYP6DG1 Dendroctonus ponderosae
51% to CYP6BH1v1 from heme to end
CYP6EG1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-7
43% to CYP6BK1 Tribolium castaneum, 37% to CYP6BQ15, N-term
CYP6EH1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-15
41% to CYP6BQ2 Tribolium castaneum
41% to CYP6CR2 Dendroctonus ponderosae
CYP6EJ1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-21
42% to CYP6AT1 Phyllopertha diversa scarab beetle
CYP6EK1 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Jiang Hongbo
submitted to nomenclature committee 9/17/2010
48% to Cyp6a2 Drosophila melanogaster
CYP6EL1 Locusta migratoria manilensis
No accession number
Rongrong Yu
Submitted to nomenclature committee Dec. 12, 2010
49% to CYP6BQ13v1 Tribolium castaneum
CYP6EL2 Linepithema humile (argentine ant)
No accession number
CYP6EL3 Linepithema humile (argentine ant)
No accession number
CYP6EL4P Linepithema humile (argentine ant)
No accession number
CYP6EL5P Linepithema humile (argentine ant)
No accession number
CYP6EL6 Linepithema humile (argentine ant)
No accession number
CYP6EL7 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
83% to CYP6EL2 Linepithema humile
CYP6EM1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
50% to CYP6DT5v1 Trialeurodes vaporariourum (whitefly)
CYP6EN1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
52% to CYP6DX1 Trialeurodes vaporariourum (whitefly)
CYP6EP1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
53% to CYP6CX1v1 Bemisia tabaci
CYP6EQ1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
50% to CYP6CX1v2 Bemisia tabaci
CYP6ER1 Nilaparvata lugens (brown planthopper)
No accession number
Chris Bass
Submitted to nomenclature committee April 18, 2011
43% to CYP6CS1 Nilaparvata lugens
CYP6ER2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
62% to CYP6ER1 Nilaparvata lugens
mid region
CYP6ER3 Laodelphax striatellus (small brown planthopper)
No accession number
Xu Lu
Submitted to nomenclature committee June 11, 2012
73% to CYP6ER1 Nilaparvata lugens
CYP6ES1 Linepithema humile (argentine ant)
No accession number
CYP6ES2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
57% to CYP6ES1 Linepithema humile
CYP6ES3 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
68% to CYP6ES1 Linepithema humile
CYP6ES4 Solenopsis invicta (fire ant)
See Solenopsis page
78% to CYP6ES3
CYP6ES5 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
64% to CYP6ES1 Linepithema humile
CYP6ET1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
51% to CYP6N18 Culex pipiens
CYP6EU1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
47% to CYP6AG6 Aedes aegypti, top 16 hits are CYP6AG
CYP6EV1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
40% to CYP6M2 Anopheles gambiae
96% to CYP6EV2 mostly identical with small regions of diffs
CYP6EV2 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
41% to CYP6M2 Anopheles gambiae
96% to CYP6EV1 mostly identical with small regions of diffs
CYP6EV3 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
41% to CYP6M2 Anopheles gambiae
58% to CYP6EV4, 58% to CYP6EV2, 56% to CYP6EV5, 57% to CYP6EV1
CYP6EV4 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
43% to CYP6M3 Anopheles gambiae
CYP6EV5 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
41% to CYP6M3 Anopheles gambiae
CYP6EW1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
43% to CYP6AA3 Anopheles minimus
61% to CYP6EW2
CYP6EW2 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
43% to CYP6AA9 Culex pipiens
61% to CYP6EW1
CYP6EX1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
42% to CYP6M2 Anopheles gambiae
CYP6EY1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
43% to CYP6N2 Anopheles gambiae
CYP6EZ1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
CYP6FA1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
51% to CYP6AE33 Heliconius melpomene
CYP6FA2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
62% to CYP6FA1 Heliconius melpomene
CYP6FB1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
46% to CYP6BQ7
CYP6FC1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
53% to CYP6CR2 Dendroctonus ponderosae
CYP6FD1 Locusta migratoria manilensis
No accession number
Yanqiong Guo
Submitted to nomenclature committee Aug. 5, 2011
78% to CYP6FD2, 46% to CYP6AM1
CYP6FD2 Locusta migratoria manilensis
No accession number
Yanqiong Guo
Submitted to nomenclature committee Aug. 5, 2011
78% to CYP6FD1, 45% to CYP6AM1
CYP6FE1 Locusta migratoria manilensis
No accession number
Yanqiong Guo
Submitted to nomenclature committee Aug. 5, 2011
47% to CYP6FD1, 45% to CYP6AM1
CYP6FF1 Locusta migratoria manilensis
No accession number
Yanqiong Guo
Submitted to nomenclature committee Aug. 5, 2011
50% to CYP6FD1, 46% to CYP6AM1
CYP6FG1 Locusta migratoria manilensis
No accession number
Yanqiong Guo
Submitted to nomenclature committee Aug. 5, 2011
38% to CYP6FD1, 37% to CYP6F4 Culex pipiens
CYP6FH1 Agrilus planinennis (wood boring beetle)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Aug. 23, 2011
50% to CYP6BQ11
note: this was attributed to Cimex before.
CYP6FH2 Agrilus (Emerald ash borer)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Nov. 10, 2011
55% to CYP6FH1 Agrilus planinennis
CYP6FH3 Agrilus planipennis
No accession number
Swapna Priya Rajarapu
Submitted to nomenclature committee March 20, 2012
91% to CYP6FH1
CYP6FJ1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 45% to CYP6CW1 Nilaparvata lugens
CYP6FK1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 42% to CYP6P10v1 Ochlerotatus sollicitans
42% to CYP6P12v1 Aedes aegypti
CYP6FL1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
36% to CYP6CW1 Nilaparvata lugens, 35% to CYP6BK6 Tribolium castaneum
N-term
CYP6FL2 Laodelphax striatellus (small brown planthopper)
No accession number
Xu Lu
Submitted to nomenclature committee June 11, 2012
87% to CYP6FL1 Laodelphax striatellus
CYP6FM1 Plutella xylostella
Gene number CCG013454.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Complete 50% to CCG005902.4 (CYP6BG4)
49% to 6AE12v2 Helicoverpa armigera
CYP6FN1 Harmonia axyridis (ladybug)
CYP6FN2 Harmonia axyridis (ladybug)
CYP6FP1 Harmonia axyridis (ladybug)
CYP6FP2 Harmonia axyridis (ladybug)
CYP6FP3 Harmonia axyridis (ladybug)
CYP6FP4 Harmonia axyridis (ladybug)
CYP6FP5 Harmonia axyridis (ladybug)
CYP6FP6 Harmonia axyridis (ladybug)
CYP6FQ1 Harmonia axyridis (ladybug)
CYP6FR1 Lucilia sericata (sheep blowfly)
CYP6FR2 Lucilia sericata (sheep blowfly)
CYP6FS1 Lucilia sericata (sheep blowfly)
CYP6FT1 Lucilia sericata (sheep blowfly)
CYP6FU1 Laodelphax striatellus (small brown planthopper)
No accession number
Xu Lu
Submitted to nomenclature committee June 11, 2012
45% to CYP6AX2 Laodelphax striatellus
CYP6 fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-4
50% to CYP6BK11 Tribolium castaneum C-term
56% to CYP6BQ15
49% to CYP6BJ1v1
too short to name yet.
CYP6 fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP3 clan
Clone name seq 14
43% to CYP6EJ1 Leptinotarsa decemlineata
short seq before the I-helix
CYP6-un1 Acyrthosiphon pisum (pea aphid)
AUG5s17796g1t1p SCAFFOLD17796:3506..66376 (+ strand)
possible pseudogene
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
36% to CYP6BX1 Dendroctonus ponderosae C-term no Cys
CYP3 clan
MFVPRKNSRFSIIALSFLLRNLVADVNILAVRISFLFIPPSADVADKQVRLDMFEFVTGTIEQTAALVTGALYELARDQNIQNHLREHLDSVLDEHQEQVTIDQWXXXXXXXXXXXXXXXXXXNQTLRKYPLAAVVRRVATKPYVVPGTGGRGTIEPDSLIVVPVYELHHDAEHFTEPEKFQPHRFPGQLSSAYMPHGSGPQSYIGKHFVELEAKLVIAMLMSRYEVHVDSATPGTPPDPLDRKSFEGVRMTVANRSSVRESTMGASLRQFHMSNGVNSGDRKFLFF
7A Subfamily
CYP7A1 human
GenEMBL L04629 to L04634 PIR S29818 (504 amino acids)
Nishimoto,M., Noshiro,M. and Okuda,K.
Structure of the gene encoding human liver cholesterol 7
alpha-hydroxylase.
Biochim. Biophys. Acta 1172, 147-150 (1993)
CYP7A1 human
GenEMBL L07951 (3880bp)
Thompson,J.F., Lira,M.E., Lloyd,D.B., Hayes,L.S.,
Williams,S. and Elsenboss,L.
Cholesterol 7 alpha hydroxylase promoter separated from
cyclophilin psuedogene by alu sequence.
Biochim. Biophys. Acta 1168, 239-242 (1993)
Cohen,J.C., Cali,J.J., Jelinek,D.F., Mehrabian,M.,
Sparkes,R.S., Lusis,A.J., Russell,D.W. and Hobbs,H.H.
Cloning of the human cholesterol 7 alpha hydroxylase
gene (CYP7) and localization to chromosome 8q11-q12.
Genomics 14, 153-161 (1992)
PIR A42201 (25 amino acids)
Molowa,D.T., Chen,W.S., Cimis,G.M. and Tan,C.P.
Transcriptional regulation of the human cholesterol
7 alpha hydroxylase gene.
Biochemistry 31, 2539-2544 (1992)
CYP7A1 human
GenEMBL L20569 (2575bp upstream region)
GenEMBL L20570 (2317bp exons 5 and 6)
Chiang, J.Y.L. and Wang,D.-P.
Genomic cloning and sequencing of human cholesterol 7a-
hydroxylase gene (CYP7).
unpublished (1993)
CYP7A1 human
GenEMBL L13460 (4959bp)
Wang.D.-P. and Chiang,J.Y.L.
Cloning, sequencing and analysis of human cholesterol 7a-
hydroxylase gene (CYP7).
Genomics 20, 320-323 (1994)
CYP7A1 Pan troglodytes (chimp)
XM_519773.2 3 aa diffs to human
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGC ALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHF ATSAKAFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESVSELISLRMFLNDTLSTFDDLEKA KTHLVVLWASQANTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPIC LSQAELNDLPVLDSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ LMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
CYP7A1 Macaca fasicularis (cynomolgus monkey)
DQ074791
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP7A1_8F1
94% to 7A1 human partial sequence
IFGRDLTRQDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRT
AHSAREKLAESLRHENLQKRESVSELIRLRMFLNDTLSTFDDLEKAKTHLVVLWASQA
NTIPATFWSLFQMIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQTQLNDLPVL
ESIIKESLRLSSASLNIRTAKEDFTLHLEEGSYNIRKDDIIALYPQLMHLDPEIYPDP
LIFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRVFAIHEIKQFLVLML
SYFELELVEGQDKCPPLDQSRAGLGILPPLYDIEFKYRFKHL
CYP7A1 Macaca mulatta (rhesus monkey)
NM_000780
MMTTSLIWGIAIAACCCLWLILGIRRR (2)
QTGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCKLMGKYVHFITNPLSY
HKVLCHGKYFDWKKFHFATSAK (0)
AFGHRSIDPMDGNTTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSN
SKTAAWVTEGMYSFCYRVMFEAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPA
LVAGLPIHMFRTAHNAREKLAESLRHENLQKRESISELISLRMFLNDTLSTFDDLEKA
KTHLVVLWASQANTIPATFWSLFQMIR (2)
NPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVL (1)
DSIIKESLRLSSASLNIRTAKEDFTLHLEDGSYNIRKDSIIALYPQLMHLDPEIYPDPL (0)
TFKYDRYLDENGKTKTTFYCNGLKLKYYYMPFGSGATICPGRLFA
IHEIKQFLILMLSYFELELIEGQAKCPPLDQSRAGLGILPPLNDIEFKYKFKHL*
CYP7A1 Bos taurus (cow)
See cattle page for details
MMSLSLIWGIVIAVCCCLYLLGMRRR (2) 5259
QMGEPPLENGLIPYLGCALQFGANPLEFLRANQRKHGHVFTCRLMGNYVHFITNPLSYH 3625
KVLCHGKYFDWKKFHFTASAK (0)
AFGHRSIDPSDGNTTDTISKTIIKTLQGDALSSLTEAMMGNLQLVLRPQGPPQPPTPTW 2193
VTEGMYSFCYRVMFEAGYLTLFGRDLAGQDAQKALILNSLDNFKQFDKIFPALVAGFPIH 2013
VFKTGHYAREKLTEGLRLQKFRERDHISELVRFLNDTFATLDDTERAKSLLAVLWAS 1842
QANTIPATFWSLFQMIR
RNPEAMKAATEEVNKTLENAGQKVSFEDSPIHLNQTQLDNMPVL (1)
60 DSIIKESLRLSSASLNIRTAKEDFTLHLQDGSYNIRKDDIIALYPQLMHLDPEIYP 239
240 DPLTFKYDRYLDENGKTKTTFYSNGLKLKYYYMPFGSGVTICPGRLFAVQEIKQFLILML 419
420 SYFELELVESCVKCPPLDQSRAGLGILPPLYDTEFRYKFKHS* 548
CYP7A1 pig
AK230789.1
88% to cow 7A1
MMSISLLGGIVTAVCCCLWLLLGMR
RRQTGEPPLENGIIPYLGCALQFGANPLEFLRANQRKHGHIFTCQLMGNYVHFITNPLSY
HKVLCHGKYLDWKKFHFTASAKAFGHRSIDPSDGNTTDNINKTIIKTLQGDALNLLAAAM
MENLQLVLRPQVAPQPEKPAWVTEGMYSFCYRVMFEAGYVTLFGKDPIGHDAQKALILNN
LDNFKQFDKIFPALVAGFPIHVFKTGHYAREKLAEGLRLQKLRKRDHISELVRFLNDTLS
TLDDAEKAKSLLAVLWASQANTIPATFWCLFQTIRSPEAMKAASEEVNKTLEKAGQKISL
DDKPIYLNQIELDSMPVLDSIIKESLRLSSASLNIRTAKEDFTLHLQDGSYNIRKDDIIA
LYPQLMHLDPEIYPDPLTFKYDRYLDENGKTKTTFYSHGLKLKYYYMPFGSGATICPGRL
FAVQEIKQFLILMLSYFDLELVESHVKCPPLDQSRAGLGILPPSNDIEFRYKLKHL*
CYP7A1 Canis familaris (dog)
XM_544091.1
MMTISLIWGIVVAVCCCLWLIFGMRRRQMGEPPLENGLIPYLGC
ALKFGANPLEFLRANQRKYGHVFTCRLMGNYVHFITNPLSYQKVLCHGKYLDWKKFHF
TTSAKAFGHRSIDPSDGNTTENINKTFIKTLQGDALNSLTEAMMENLQLVMRCPLVSK
SKTPAWVTEGMYSFCYRVMFEAGYLTLFGKDLTGQDAQKGLILNNLDHFKEFDKIFPA
LVAGLPIHVFKTAHHAREKLAEGLRHENLGKRDHISELVRFLNDMLSTLDDMDKAKTH
LAILWASQANTIPATFWSLFQMIRSPEAMKAATEEVNKTLENAGQKISLDGSPICLNQ
MQLNDMPVLDSLIKESLRLSSASLNIRTATEDFTLHLQDSSYNIRKDDIIAFYPQLVH
LDPEIYPDPLTFKYDRYLDENGKTKTTFYSNGIKLKYYYMPFGSGATMCPGRLFAVQE
IKQFLILMLSYFELELVESQVKCPPLDQSRAGLGILPPLNDIEFKYKFKHL
CYP7A1 rat
GenEMBL U01962 (7998bp)
Chiang, J.Y.L. and Stroup,D.
Identification and characterization of a putative bile acid responsive
element in cholesterol 7 alpha-hydroxylase gene promoter.
J. Biol. Chem. 269, 17502-17507 (1994)
CYP7A1 rat
PIR S27206 (26 amino acids)
Chiang, J.Y.L., Yang, T.P. and Wang, D.P.
Cloning and 5'-flanking sequence of a rat cholesterol 7alpha-
hydroxylase gene.
Biochim. Biophys. Acta 1132, 337-339 (1992)
CYP7A1 rat
PIR A35609 (26 amino acids)
Jelinek, D.F. and Russell, D.W.
Structure of the rat gene encoding cholesterol
7alpha-hydroxylase.
Biochemistry 29, 7781-7785 (1990)
CYP7A1 rat
Lee, Y.-H., Alberta,J.A., Gonzalez,F.J. and Waxman,D.J.
Multiple functional DBP sites on the promoter of the cholesterol 7
alpha hydroxylase P450 gene CYP7. Proposed role in diurnal regulation
of liver gene expression.
J. Biol. Chem. 269, 14681-14689 (1994)
CYP7A1 rat
GenEMBL Z18860 (?bp)
Hoekman,M.F.M., Rientjes,J.M.J., Twisk,J., Planta,R.J., Princen,H.M.G.
and Mager,W.H.
Gene 130, 217-223 (1993)
note: promoter sequence
CYP7A1 rat
Ramirez et al.
Cholesterol amd bile acids regulate...
Molec. Cell. Biol. 14, 2809-2821 (1994)
CYP7A1 rabbit
GenEMBL S67315 (770bp)
Poorman,J.A., Buck,R.A., Smith,S.A., Overturf,M.L. and
Loose-Mitchell,D.S.
Bile acid excretion and cholesterol 7 alpha-hydroxylase expression
in hypercholesterolemia-resistant rabbits
J. Lipid Res. 34, 1675-1685 (1993)
CYP7A1 rabbit
GenEMBL L10754 (3002bp)
Kai,M., Eto,T.,Kondo,K.-H., Setoguchi,Y., Maeda,Y., Higashi,S.
and Setoguchi,T.
Effects of bile acids feeding on cholesterol 7 alpha-hydroxylase
mRNA levels in subtotally cecectomized rabbits
J.Lipid Res. 36, 367-374 (1995)
CYP7A1 Cricetulus griseus (hamster)
GenEMBL L04690 (10614bp)
Crestani,M., Galli,G. and Chiang,J.Y.
Genomic cloning, sequencing, and analysis of the hamster
cholesterol 7 alpha-hydroxylase gene (CYP7)
Arch. Biochem. Biophys. 306, 451-460 (1993)
Cyp7a1 mouse
GenEMBL L23754 (2939bp) EST AA254999
Tzung,K.-W., Ishimura-Oka,K., Kihara,S., Oka,K. and Chan,L.
Structure of the mouse cholesterol 7 alpha-hydroxylase gene.
Genomics 21, 244-247 (1994)
MMSISLIWGIAVVVSCCIWFIIGIRRRKVGEPPLDNGLIPYLGC
ALKFGSNPLEFLRAKQRKHGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHY
TTSAKAFGHRSIDPSDGNTTENINKTFNKTLQGDALCSLSEAMMQNLQSVMRPPGLPK
SKSAVWVTEGMYAFCYRVMFEAGYLTLFGKDISKTDTQRAFIQNNLDSFKQFDQVFPA
LVAGVPIHLLKTAHKARERLAESLKHKNLYMRDQVSELIRLRMFLNDTLSTFDDMEKA
KTHLVILWASQANTIPATFWSLFQMIRSPEAMKAASEEVNGSLQSAGQELSSGGNAIY
LDQEQLNNLPVLDSIIKEALRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQ
LMHLDPEIYPDPLTFKYDRYLDESGKAKTTFYRNGNKLKYFYMPFGSGATICPGRLFA
VQEIKQFLILMLSYFELELVESHTKCPPLDQSRAGLGILPPLNDIEFKYKLKH
CYP7A1 Monodelphis domestica (gray short-tailed opossum)
DQ051398
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN
TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF
EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE
SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ
MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS
LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK
TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD
QSRAGLGILPPLNDIEFKYKFKHL*
CYP7A1 Gallus gallus (chicken)
NM_001001753
Christoph Handschin
Submitted to nomenclature committee 3/27/02
66% to human 7A1
MFIAPWIWGTVIIVCCSFWFLFGRRRRRRQGEPPLENGFLPYLG
CALQFGANPLKFLREKQKKHGHIFTCQVAGKYIHFLTDPFSYHSLIRQGKHLDWKKFH
FATSAKAFGHGSIDPAEGNTTENFHHTFIRTLQGNALDALIKAMMENLQYVMLQSRAS
KFQPNTWVTEGLYTFCCQVMFESGFLTLFGKEFNSNHDKNLSKRETERARILNALENF
KEFDKIFPALVAGLPIHLFKSAHSAREKLGEALLHKNLLKRDNLSELVMLRMFLNDTL
STFDDMEKAKTHVAVLWASQANTIPATFWSLFYLLKNPEAMRAATKEVQSVLESAGEK
ISLDGNYISLNRKQLDNMPVLDSIIKEAMRLSSASMTFRVAKEDFTLHLENSFYNIRK
DDIVALYPQLLHFDPEIYADPLTLKYDRYLNENKEEKTDFYRNGRKLKYYYMPFGAGI
AKCPGRLFAVHEIKQFLVLIFSYFEIDLVDSNVQCPSLDQSRAGLGILQPSNDIDFRY
RLKCL
CYP7A1 Xenopus tropicalis (Western clawed frog)
scaffold_8:3335708-3339166 UCSC browser
5102_prot
64% to human 7A1
MLTVSLIWGLVVALCCFFWLIVGIRRRQPGEPPLENGLIPYLGCALQFGA
NPLEFLRVRQNKFGNVFTCKIAGQFVHFVTDPFSFNSVMRHGRHFDWQKF
HFATSAKAFGHSNIDSSDSEVTQNVHDSFLKTLQGDALDPLISNMMENLQ
HTMLQNSSYKVNSKDWVTEGLYAFCYRVMFEAGYLTLFGKEFNSPEDKNL
ARQEAQRALILNAIENFKEFDKIFPALVAGLPIHVFKSAYSARENLAKDL
LHENLRKRNNISELISLRMFLNESMTSLNDMEKAKTHLALLWASQANTLP
ATFWSVFYLLRCPHAMKASTEEVQRVLEKASQKVNCDGRYIFLNRHELDD
MPVLDSIIKEAMRLSSASLNIRVAKENFVLHIDDKQAFNIRKDDIVALYP
QMVHLNPDIYEDPNNFKYDRYLGEDGKEKTSFFLNGRKLKYYYMPFGSGK
TKCPGRQFAVHEIKQMLTLIICYFDMELVDKNIRSPPLDQSRAGLGILQP
THDVDFRYKLKAH
CYP7A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP7A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_5172
59% to 7A1 human
14694 MILSIALIWAVVVGFCCLLWLAVGIRHR 14777 (2)
15070 HSSEPPVENGLIPYLGCALQFGANPLQFLRSRQKKYGHIFTCKIA 15204 frameshift
15205 GQYIHFLCDPFSYHSVIRQGRHLDWRKFHFATSVK 15310 (0 expected) bad boundary
15425 AFGHDSFDPRHGHTTENLHQ 15484
15485 TFLKTLQGEALPSLIKTMMGHLQDVMLKSDTLRRSKDHWEVDGIFAFCYK 15634 (0)
15757 VMFESGYLTLFGKELGEDTCQARQAAQKALVLNALENFKEFDKIFPALVAGLPIHVFKSAYSARE 15951 (0)
16053 NLAKTMHAEKLSKRENVSDLISMRMILNDSLSTFNDVSKARTHVALLWASQANTLPATFWSLFYMIR 16253 (2)
16383 SPDAIKAAREEAQKVFETFGVKIDPHNPTLNLTRDVLDNMPVL 16511 (1)
16744 DSIIKEAMRLSSASLNIRVAKEDFLLHLDNQEAYRIRKDDVIALYPPMLHYDPEIFEDPY 16923 (0)
17029 EYKFDRFLDENNQEKTTFTRNGRKL 17103
17104 RYFYMPFGSGVTKCPGRFFAVYEIKQFLTLVLTYFDMELLDPAIQVPPLDQSRAGLGILQ 17283
17284 PTYDVDFRYKLKLAY* 17331
CYP7A1 Tetraodon nigroviridis (freshwater puffer)
95% TO FUGU CYP7A1
EXON 3 FROM CAAE01017512.1
MILSIALIWAVVVGFCCLLWLAVGIRHR (2)
QSSEPPVENGLIPYLGCALQFGANPLQFLRSRQKKYGHIFTCKIA
GQYIHFLCDPFSYHSVIRQGRHLDWRKFHFATSVK (0)
AFGHDSFDPRHGHTTENLHQTFLKTLQGEALPSLIKAMMGHLQDAMLKSDTLSRSKDRWEVDGIFAFCYK (0)
vmfeSGYLTLFGKELGEDKCQARQEAQKALVLNALENFKEFDKIFPALVAGLPIHVFKSAYCARE (0)
NLAKTMHAEKLSKRENVSDLISMRMILNDSLSTFNDVSKARTHVALLWASQANTLPATFWSLFYMIR (2)
SPDAMKAAREEVQKVFETFGLKIDPDNPTLNLTRDVLDNMPVL (1)
DSIMKEAMRLSSASLNIRVAKEDFLLHLDNQEAYRIRKDDVIALYPPMLHYDPEIYEDPY (0)
EYKFDRFLDEKGQEKTTFTRKGRKLRYFYMPFGSGVTKCPGR FFAVYEMKQFLSLVLSYFDMELLDPAIQVPPLDQSRAGLGILQPTYDVDFRYKLRSVY*
7B Subfamily
CYP7B1 human
GenEMBL AF029403
Setchell,K.D.R., Schwarz,M., O'Connell,N.C., Lund,E.G., Davis,D.L.,
Lathe,R., Thompson,H.R., Weslie Tyson,R., Sokol,R.J. and
Russell,D.W.
Identification of a new inborn error in bile acid synthesis:
mutation of the oxysterol 7alpha-hydroxylase gene causes severe
neonatal liver disease.
J. Clin. Invest. 102, 1690-1703 (1998)
CYP7B1 Pan troglodytes (chimpanzee)
XM_001159731.1
99% (3 aa diffs) to human
MAGEVSAATGRFSLERLGLPGLALAAALLLLALCLLVRRTRRPG EPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQLV IKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQN LKQVFEPQLLKTTSWDMAQLYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLK FDDKFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYV HEDLEIGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKG SGFPIHLTREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDL VAIFPPILHGDPEIFEAPEEFRYDRFIEDGKKKTTFFKRGKKLKCYLMPFGTGTSKCP GRFFALMEIKQLLVILLTYFDLEIIDDKPIGLNYSRLLFGIQYPDSDVLFRYKVKS
CYP7B1 Bos taurus (cow)
See cattle page for details
MNAGMGGFWPEPWLTRSLGYPGLALAAALLLLVLCLNARRTR (2)
RPGEPPLIKGWLPYFGQALKLQKDPLGFMTSLQKQYGDIFTLLLG (1)
GKYITFILDPFHYTSVAKNQKLSFQIFTNKFLKRVFSIKKMLTDSDLIDEIHSTYQ 56
3 FLQGKHLDILMESTMQNLKQVFEPQLLKTTSWSTEYLLPFCNSVIFEMTFTTIYGNILAD 182
183 DKKTFITELKDDFLKFDEKFTRLASGIPIELLGNIKSVRTKLIKDLTIESLAKLQGMSEV 362
363 VQRRNDILEKYYTPKDTEIG (1)
AHHLGLLWASVTNTVPTMFWAMYYLLRNPKAMAVLRDEIDHLLQSTGQKKGPGFSIYLTR
EQLDSLVYL (1)
ESTILEVLRLCSFSGIFRFVQEDLTLHLESQDCCLRKGDFVVIFPPILHHDPEIFEAPD
EFRFDRFTENGKKKTTFFKRGKKLKYYHLPFGLGVSKCP
GRFLAMVEIKQLLVVLLTYFDLEIIDNKPLELNYSRFLFGIPYPDSDVLFRYKIKS
CYP7B1 pig
AJ956520.1, AJ955923, CK455462.1, CJ000103.1
MGRFSPEPWLPQLLSPRGLALAAALLLLVLFLRTRRTRRPGEPPLVKSWLPFIGEAL
KLQRDPIGFMTTLQKQYGDIFTVLLGGKYITFILDPFQYQSVIKNQKLSFRGFSNKVLL
RVFSIKKLVEDDAMNDELHTCYQLLQGRHLDMLMENTMQSLKQVFEPQLLKTTSWHTESL
FTFCNSVIFEMTLTTVYGSILLGHRKTFITELKDDFFKFDGKFTQLASGMPIELLGNIKSIRLKLIKL
LTTENLAKFQGWSEVVQRRQDILEKYYLPQDIEIGAHHLGLLWASVANTAPTMSWTMYYL
LRNPEAMAVLRDEIDHLLQSTGQKKGPGFSIHLTREQLDSLVYLESTILESLRLSSFSST
FRFVQEDLTLHLEAQDCCLRKGDFVGVFPPILHYDPEIFEAPEEFRFDRFVENGKKKTTF
FKRGKKLKYYLMPFGFGISKCPG
RFLAVVEIKQLLVILLTYFDLEIIDDKPVKLNFSRSLFGIQHPDSDVSFRYKVKS*
CYP7B1 Canis familaris (dog)
XM_544102.2
MNGHTSGSLQFSTVPSAWRTLGVLESEWTKKGESAAKRQKVTEL
QVRCEYNVNGDRAEMSAPPPSGGSTWAAIQWMGPSSTKEERGCDEQISPRRPGEPPLI
KGWLPYLGEALKLQKDPLGFLRTLQKQHGDTFTLFAGGKYITFILDPFQYQLIMKTHK
LSFRIFSNKLSRKVFSIKKLETTDDLSNDLHGCYHLLQGKSLDVLTETMMQNLKQVFE
LHLLKTTNWDMAHLLTFCSSIIFEITLKTIYGKSLAGNGEKFITELRDNFLKFDDKFP
YLISDIPIELLGNIKSIRKKLIKHLASEHLGKTQGWSEIVQMRQDVLEKYYTLEDFEV
GAHHLGFLWASVTNTIPTMFWAMYYLLQHPEAMAVLRDEIDHLLQSTGQKKGSGFPMH
LTREQLDNLVYLESTVLEVLRIRSFSSIIRFVQEDLTLHSETQDYCLRKGDLVALFPP
AIHYDPEIFEAPEEFRFDRFVEDGKKKTTFFKKGKRLKYYLLPFGIGTSKCPGRFLAV
VEIKQLLVVLLTYFDLELIDDKPVVANRSRLLLGVQHPASDVFFRYKVKT
CYP7B1 rat
GenEMBL U36992 (1763bp)
Stapleton,G., Steel,M., Richardson,M., Mason,J.O., Rose,K.A.,
Morris,R.G.M. and Lathe,R.
A novel cytochrome P450 expressed primarily in brain.
J. Biol. Chem. 270, 29739-29745 (1995)
Cyp7b1 mouse
GenEMBL U36993 (1880bp)
Stapleton,G., Steel,M., Richardson,M., Mason,J.O., Rose,K.A.,
Morris,R.G.M. and Lathe,R.
A novel cytochrome P450 expressed primarily in brain.
J. Biol. Chem. 270, 29739-29745 (1995)
39% identical to CYP7A subfamily
Ken A. Rose, Genevieve Stapleton, Karin Dott, Marie Paule Kieny, Ruth
Best, Margrit Schwarz, David W. Russell, Ingemar Bjšrkhem, Jonathan
Seckl, and Richard Lathe
Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of
neurosteroids 7-
alpha hydroxy dehydroepiandrosterone and 7-alpha hydroxy pregnenolone
Proc. Natl. Acad. Sci. USA 94, 4925-4930 (1997)
MQGATTLDAASPGPLALLGLLFAATLLLSALFLLTRRTRRPREP
PLIKGWLPYLGMALKFFKDPLTFLKTLQRQHGDTFTVFLVGKYITFVLNPFQYQYVTK
NPKQLSFQKFSSRLSAKAFSVKKLLTDDDLNEDVHRAYLLLQGKPLDALLETMIQEVK
ELFESQLLKITDWNTERIFAFCGSLVFEITFATLYGKILAGNKKQIISELRDDFFKFD
DMFPYLVSDIPIQLLRNEESMQKKIIKCLTSEKVAQMQGQSKIVQESQDLLKRYYRHD
DSEIGAHHLGFLWASLANTIPAMFWAMYYILRHPEAMEALRDEIDSFLQSTGQKKGPG
ISVHFTREQLDSLVCLESTILEVLRLCSYSSIIREVQEDMNLSLESKSFSLRKGDFVA
LFPPLIHNDPEIFDAPKEFRFDRFIEDGKKKSTFFKGGKRLKTYVMPFGLGTSKCPGR
YFAVNEMKLLLIELLTYFDLEIIDRKPIGLNHSRMFLGIQHPDSAVSFRYKAKSWRS
CYP7B1 Monodelphis domestica (gray short-tailed opossum)
DQ037866
RPGEPPLIKGWLPYLGVVLNLRKDPLRFMKTLQKQHGDTFTVLLGGKYITFILDPFQYQL
VIKNHKQLSFRVFSNKLLEKAFSISQLQKNHDMNDELHLCYQFLQGKSLDILLESMMQNL
KQVFEPQLLKTTSWDTAELYPFCSSIIFEITFTTIYGKVIVCDNNKFISELRDDFLKFDD
KFAYLVSNIPIELLGNVKSIREKIIKCFSSEKLAKMQGWSEVFQSRQDVLEKYYVHEDLE
IGAHHLGFLWASVANTIPTMFWAMYYLLRHPEAMAAVRDEIDRLLQSTGQKKGSGFPIHL
TREQLDSLICLESSIFEALRLSSYSTTIRFVEEDLTLSSETGDYCVRKGDLVAIFPPVLH
GDPEIFEAPE
CYP7B1 Gallus gallus (chicken)
AY700579
Christoph Handschin
Submitted to nomenclature committee 3/27/02
54% to human 7B1
PWRRSAGGAAAAALLLWVVCVLCRRKRKTGEPPLINGWIPYLGK
ALPFRKDAFKFLLDQQKKLGDIFTVHIAGRYITFIMDPFQYVYVIRNSKQLEFHEFAD
KMASKTFDYPALSNVKFPDLKENLHRIYQYLQGKPLEIISDHMMKNLQDIFEWKCSQA
TDWETEKMYKFCCSVMFEASFVTLYGRVPAADGRKVISEIRDKFIKFDASFPYLAANI
PIELLGATKKVRKELIHHFLLQNMTKWLGGSKVVQARQDIFEKYELLGDYDKAAHHFA
FLWASVGNTIPATFWAMYYLLRHPEALAAVRDEITHLLQSTGQKRGPTYNIHLTREQL
DNLVYLESALNESLRMCSSSMNIRISQEDFVLKLEGDQEVSLRKGDWIALYPQILHMD
PEVYEDPKKYKFDRYIENGKKKTTFYKAGRKLKYFLMPFGSGISMCPGRFLAMNEMKM
FLFLLLAHFDVELGENKAVRLDNSRM
CYP7B1 Xenopus tropicalis (Western clawed frog)
CX908537.1 CX805060.1 CX814354.1 BX713865.1 CN080250.1
52% to 7B1 human
MLDTLLYTVTGLVLGGLLLLLLLPRRQ
RREGEPPLENGWIPFIGLAYEFHKNALEFLISRQQKYGDIFTVHVAGKYITFIMDSTQFQ
YVIKHGKQLDFHEFANSLSSRTFDHPRLTEAKFPHLNDKLHRIYKIMQGRALDKLTDSMM
GNLQRVFKWKFSQATDWKAEKMYQFCCCIMFEASFMTLYGRDPIADGHKVISEIREK
FTKFDAKFPYLVINIPIALLGATKKIREELIHFFFPNKMEKRSEISEVVQERKNVLEQYE
LQDYDRAAHHFAFLWASVGNTIPATFWAMYYLVRHPEALAAVRDEIDHLLQSTGQKKGP
EYDIHITREQLDSMVLLGSAIKESFRLCAASMNIRLVQEDFDLELEGNQTIRLRKDDFIA
LYPPALHMDPEIYEDPERYKYDRFVENGKEKILFYKKGKKLKEYLMPFGSGTSKCPGRFF
AMNEIKQFLAVLLIYVEMELVEHKALGHDNRRSGLGILLPNSDIMFRFKPRTLDL*
CYP7C1 Fugu rubripes (pufferfish)
No accession number
Scaffold_16085
N-terminal revised June 18, 2010
MSGLLLLLVGVLSLLVCVLRRRIR (2)
RDNEPPLVIGWIPFVGKAVEFGRDAQGFLLQQKKKFGDVFTVLIA (1)
1129 GKYMTFIMDPLMYPNIIKHGRQLDFHSFSDSMAPVVFGYPPVRSWKTPSLHEDIQ 1293
1294 RAFKLLQGDHLCALTEGMMGNLMMLLRQDHLGRRPGAGPGWKSGDMYEFCSRVMFEATFL 1473
1474 TLYGIPQEGGRHDGMDELRKDLFQFDGWFPWLVAGVPIGLLRQAKTSRNKLTRS 1635
1636 LLPMRISSWSNRSQFIRRRQELVEKVDALKDVDRA 1740 (1)
2208 AHHFAMLWASVANTIPACFWSMYNLVSHPDALQVVRQQILDELKLSGVQFSTDTDVTL 2387
2388 SRDLLDKLLYL (1)
ESSVNESLRLSSASMNIRVAQEDFSLHLKNERSANVRKGDIIVLYPQSLHMDPEVYEDPQ 2666 (0)
2786 TFQFDRYVQDSKGGFFKGGQRLKYYLMPFGSGSSMCPGRHFAVNEIKQFLCLMLLYF 2956
2957 NLELEPGQTRATVDSSRAGLGILFPSAKVHFRYRLRCV* 3073
CYP7C1 Fugu rubripes (pufferfish)
ENSTRUT00000025007
next to ARMC1
length=498 (last 6 aa do not agree with sequence from Scaffold_16085
MSGLLLLLVGVLSLLVCVLRRRIRRDNEPPLVIGWIPFVGKAVEFGRDAQ
GFLLQQKKKFGDVFTVLIAGKYMTFIMDPLMYPNIIKHGRQLDFHSFSDS
MAPVVFGYPPVRSWKTPSLHEDIQRAFKLLQGDHLCALTEGMMGNLMMLL
RQDHLGRRPGAGPGWKSGDMYEFCSRVMFEATFLTLYGIPQEGGRHDGMD
ELRKDLFQFDGWFPWLVAGVPIGLLRQAKTSRNKLTRSLLPMRISSWSNR
SQFIRRRQELVEKVDALKDVDRAAHHFAMLWASVANTIPACFWSMYNLVS
HPDLQVVRQQILDELKLSGVQFSTDTDVTLSRDLLDKLLYLESSVNESLR
LSSASMNIRVAQEDFSLHLKNERSANVRKGDIIVLYPQSLHMDPEVYEDP
QTFQFDRYVQDSKGGFFKGGQRLKYYLMPFGSGSSMCPGRHFAVNEIKQF
LCLMLLYFNLELEPGQTRATVDSSRAGLGILFPSAKVHFRYRWSSWSS
CYP7C1 Tetraodon nigroviridis (freshwater puffer)
84% TO FUGU CYP7C1
MSGLLLLFFGVLSLFICFLRRRTR (2)
RVNEPPLDIGWIPYIGKAVEFGKDAHGFLLQQKKKFGDVFTILIA (1)
GKYMTFIMDPLMYPNIIKHGRQLDFHSFSDTMAPLVFGYPPVRSYRSPSLHEDIQR
AFKLLQGDHLCALTESMMGNLMMLLRQQHLGLKPKVGSGWKTDDMYEFCSRIMFEATFN
TLYGTPQDGGRHGAVEKLRRELFQFDSWFPLLVAGIPIGLLRQAKTSRNKLLKNLLPNR
ISSWSNRSQFISRRQELVEKVDVLTDMDRA (1)
AHHFAMLWASVANTIPACFWSMYNLVSHPDALRVVRQQIFDVLKLSGVEFSVDKDVTLSKDFLDKLLYL (1)
ESAINESLRLSSASMNIRVAQEDFSLHLKNERSVKVRKDDIIVLYPQSLHMDPEVYEDPQ (0)
MFQFDRYIQDNSGKSVFFKDGQKLKYYLMPFGSGSSMCPGRHFAINEIK
QFLCLMLLYFDLELDLGQTRATVDSSRAGLGILFPSTNVRFRYRLQ*
CYP7C1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP7C1 Gasterosteus aculeatus (stickleback)
next to ARMC1 in Stickleback
43% to CYP7B1 human, 42% to CYP7A1 human
56% to CYP7C1 zebrafish, 41% to CYP7A1 zebrafish,
40% to CYP7D1 zebrafish
60% to CYP7C1 fugu, 39% to CYP7A1 fugu
(seq gap)
VTFGYPPIRGGKFPGLPEQIGRTFQLLQGDGLSALTESMMSNLLLLFRQDHLGGPPPGGA 3355
SGDWRSAGMYEFCNSIMFEATFLTIYGRPASASRHSDTGLLRRDFVRFDNMFPLLIAQIP 3175
IRLLGRTKAVRDKLIDYFLPHRMSRWADTSLFIRTRSELFEQYDALGDVDKA (1) 3019
AQHFAILWASVGNTIPATFWAMYHLARHPEALREARREIQSVLGLGDGVPFSSSRDVRLD 992
REQLEKLVYL (1) 962
ESAISESLRLSSASMNIRVAQEDFSLRLDAGRSVAVRRGDFVALYPQTMHMDPEIYEEPQ (0) 708
SFRADRFLQDGVEKTDFYKDGQRLRYYLMPFGSGSSRCPGRFFAVNEIKQFLCVLLLCV 374
DLQLEDGQAGATLDASRAGLGILLPAADVRFRYRPRNM*
CYP7D1 Danio rerio (zebrafish)
BG883457 fp29f09.x1 381-502
54% to 7A Z35725-a6349d05.p1c
N-term revised June 18, 2010
MSTFLFTVAAILLTLFIVWICGHTRKR (2)
KPGEPPLVTGWLPFIGVTKDYVSNPLGFLTETQKKHGNVFTCLIA
GKYFTFVTDPFSFSSVVRQGKNLDFQKFAINFSQR (0)
VFGHADFNSPQLSGNYREIHSIFRQTLQGPSLQHLTQSMLCNLQTVLERCLPHEHDWLEEGVQSFTNR
IMFEAGFLTLFGKEDIRFLQDHGMSGNRISMPKATQDFLVFDHAFPLLAAGVPIGLCTKAWRARE
ALAEELLHDELHRRKCISDLIQRRMDIFDRMLLDETGKARTDVCMLWASQANTLPAAFWSLYYTLK (2)
SVDAFTAARTEVNRVLLGQSLNNKDQTVYLSKDQLDSMTVL (1)
ESIIEEALRLSSASMMIRVASDDFTLTLESDQTAAIRKGDYIALYPQLLHLDPEIYPNPT (0)
EFKYNRFLDENDQPKTNFFKSGRRLRNFLMPFGSGASECPGR
FFAVYEIKLFLALTLWHYDLQLRDPDVPVVQDSARAGLGIMPPSQDVLLRFRKKQRTPGNEHKDTK*
CYP7D1 Ictalurus punctatus (channel catfish)
GenEMBL CB936535.1
73% to Danio 7D1
CYP7D1 Pimephales promelas
GenEMBL DT118939.1
73% to Danio 7D1
CYP7 Eptatretus burgeri (hagfish)
GenEMBL BJ652936.1 BJ664927.1 ESTs C-term
49% to human CYP7B1, 47% to human 7A1, 55% to Xenopus 7B1,
44% to xenopus 7A1
2 SARGLPAAFWALYHLLCHPDALTVIRKEVDDVLKSTGQYPKPSSLLKLSPTTLPNLVCLG 181
182 SAISESLRLCSASINIRVAQDDLDLELEPGRTVPLRKNDWVAMYPQTALHLDPEIYPEPE 361
362 IYKYDRFLENGQEKTNFYKGGQKLHHYLMPFGSGVSMCPGRFLALNEIKQFLFLLIAVL 538
539 DLEILPDQPQVKIDNGR 589
CYP7 Branchiostoma floridae (lancelet)
MVTELLGVCLAVVLVFVLLQVTTRR (2)
RRPGEPPLEPGPLPYLGVALEFSRNPLGFITSRWKKYGDVFTVRLAGHYTTFVLDPHSFTHAIRNSK (2)
VLDFRVFSSKIAHRAFGMPIVYGTHRDWVRADSDALYPKELQGQGLEKVTE (0)
VMMNNLQSAMLAATDVKDKWNKGELWSFVYRIMFS (1)
ASYKTLFGRHKEDEEETARLLHAMEEFQKYDKRFPEIISNVPWWLMGQTKKRYEYLK (0)
SMVSPTELSQRGVSDFIRMRQEIYADGNLSPDEMTGFNFATMWASL (0)
SNTVPAAFWTLFYLLKDPVAMDAVREEVNQ (0)
ILKETGQSLETVKEAGEMLHVTREQLNDMKCL (1)
GSAINEALRMCSASIIIRVATEDAELALESGSTFRIRKGDRVALYPGFLHMDPEVFDDPE (0)
TFKYDRFLENGMEKTTFYKNGRKLRHYLLPFGHGASMCPGRFFALNEIKQFVTIVVCYFN
MELMEKQTPPKDQSRAGLGTLAPLKECLFRYSLK*
CYP7-like Ciona savignyi
one intron shared with human CYP7A1 ortholog
seq 166
MLVSIIYTVLLLLLSSYAIWFIAKRKQKRGEPPIVPFWIPWL (1)
GSGLTYQKDPIAFLKKQTKKYGPIFTVFM (1)
GGNYFTFVTDPFTHPLVAKEGKILNFRICTLPMIKHLFDYQRPAVEEPTMGGLFVKYLQ (0)
GQRLNVMIEKMMKCLQRIMLAGKYTNTDWSEVGLLHFVESIMCTASFSTL (2)
FGDYPKSSNKDIPAFEHQMFEDFRKFDEAFPYLVKGYPLNSFK (0)
GLEESRKNFWKHLASDELNKREMVSDLIAEYARICDAEKDRTLPKKLFSTAWAAQ (0)
SNTMVSAFWTIYFVTKHGDAKAAAEVEIQRLLKETSQTLDGKTPINFNRDDMDKMTVL (1)
DSIINESLRLHVSASMLRQALQDYDLKVLSVGKTYRLRKGDRVMSLFELNHKDPEIYS
NPEVFKYDRFLNEDGSLKTDFYKNGKVVRFALQPFGSGL (2)
SKCPGRYWAVTELKQIVILLLLYFDFELINPNEEIKMNKNRVAFGSLPPTNDPKIRFPSTV*
8A Subfamily
CYP8A1 human
GenEMBL D83402
MAWAALLGLLVALLLLLLLSRRRTRRPGEPPLDLGSIPWLGYAL
DFGKDAASFLTRMKEKHGDIFTILVGGRYVTVLLDPHSYDAVVWEPRTRLDFHAYAIF
LMERIFDVQLPHYSPSDEKARMKLTLLHRELQALTEAMYTNLHAVLLGDATEAGSGWH
EMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQLDRLLPKLA
RGSLSVGDKDHMCSVKSRLWKLLSPARLARRAHRSKWLESYLLHLEEMGVSEEMQARA
LVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVSQTTTLPQKV
LDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRLLLFPFLSPQ
RDPEIYTDPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHCLGRSYAVNS
IKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIRP
CYP8A1 Pan troglodytes (chimpanzee)
XM_514713.3
PTGIS prostacyclin synthase
98% to human, except at the N-term
chimp N-term may be in a seq gap and this N-term may
be a prediction error
MPAASQSRSRDGLGALLGLWRTVAAAATEPRRTR
RPGEPPLDLG
SIPWLGYALDFGKDAASFLTRMKEKHGDIFTILVGGRYITVLLDPHSYDAVVWEPRTR LDFHAYAIFLMERIFDVQLPHYSPSDEKARMKPTLLHRELQALTEAMYTNLHTVLLGD ATEAGSGWHEMGLLDFSYSFLLRAGYLTLYGIEALPRTHESQAQDRVHSADVFHTFRQ LDRLLPKLARGSLSVGDKDHMCSVKSRLWKLLSPARLATRAHRSKWLESYLLHLEEMG VSEEMQARALVLQLWATQGNMGPAAFWLLLFLLKNPEALAAVRGELESILWQAEQPVS QTTTLPQKVLDSTPVLDSVLSESLRLTAAPFITREVVVDLAMPMADGREFNLRRGDRL LLFPFLSPQRDPEIYADPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNHC LGRSYAVNSIKQFVFLVLVHLDLELINADVEIPEFDLSRYGFGLMQPEHDVPVRYRIR P
CYP8A1 bovine
GenEMBL D30718 (2206bp)
Hara,S., Miyata,A., Yokoyama,C., Inoue,H., Brugger,R.,
Lottspeich,F., Ullrich,V. and Tanabe,T.
Isolation and molecular cloning of prostacyclin synthase from bovine
endothilal cells.
J. Biol. Chem. 269, 19897-19903 (1994)
CYP8A1 bovine
GenEMBL L34208 (1920bp)
Pereira,B., Wu,K.K. and Wang,L.-H.
Molecular cloning and characterization of bovine prostacylin
synthase.
Biochem. Biophys. Res. Commun. 203, 59-66 (1994)
CYP8A1 bovine
GenEMBL S67757 (676bp)
Pereira,B., Wu,K.K. and Wang,L.-H.
Bovine prostacyclin synthase: purification and isolation of partial
cDNA.
Biochem. Biophys. Res. Commun. 197, 1041-1048 (1993)
CYP8A1 Bos taurus (cow)
See cattle page for details
30 MSWAVVFGLLAALLLLLLLTRRRTRRPGEPPLDLGSIPWLGHALEFGKDAAGFLTRMKEK 209
210 HGDIFTVLVGGRHVTVLLDPHSYDAVVWEPRSRLDFHAYAVFLMERIFDVQLPHYNPGDE 389
390 KSKMKPTLLHKELQALTDAMYTNLRTVLLGDTVEAGSGWHEMGLLEFSYGFLLRAGYLTQ 569
570 YGVEAPPHTQESQAQDRVHSADVFHTFRQLDLLLPKLARGSLSAGDKDRVGKVKGRLWKL 749
750 LSPTRLASRAHRSRWLESYLLHLEEMGVSEEMQARALVLQLWATQGNMGPAAFWLLLFLL 929
930 KNPEALAAVRGELETVLLGAEQPISQMTTLPQKVLDSMPVLDSVLSESLRLTAAPFITRE 1109
1110 VVADLALPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPEVFKYNRFLNPDGSEKKDF 1289
1290 YKDGKRLKNYSLPWGAGHNQCLGKGYAVNSIKQFVFLVLTQFDLELITPDVDIPEFDLSR 1469
1470 YGFGLMQPEHDVPVRYRIRP* 1532
CYP8A1 human
GenEMBL D38145 (1977bp) PIR JC2231(500 amino acids)
Miyata,A., Hara,S., Yokoyama,C., Inoue,H., Ullrich,V. and
Tanabe,T.
Molecular cloning and expression of human prostacyclin synthase.
Biochem Biophys.Res. Commun. 200, 1728-1734 (1994)
CYP8A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
90% to human 8A1, full seq. is not known
Ortholog of human CYP8A1
CYP8A1 Sus scrofa (pig)
Pig ESTs BP457025.1, BE013722.1, BE013644.1, AJ666831.1
lower case = cow seq
mswavvfgllaallllllltrrrtrrpgeppldlgsipwlghalefgkdaagfltrmkek
hgdiftvlvggrhvtvlldphsydavvweprsrldfhayavflmerifdvqlphynpgde
kskmkptllhkelqaltdamytnlrtvllgdtveagsgwhemgllefsygfllragyltq
ygveapphtqesqaqdrvhsadvfhtfrqldlllpklargslsagdkdrvgkvkgrlwkl
lsptrlasrahrsrw
LESYLQHLEEMGVSEQMQARALVLQLW
ATQGNMGPAAFWLLLFLLKNPEALAAVRGELEPILSRAEQPISQMTTLPQKVLDSTPVLD
SVLSESLRLTAAPFITREVVADLALPMADGREFTLRRGDRLLLFPFLSPQKDPAIYTDPE
VFKYNRFLNPDGSEKRDFYKDGKRLKNYSLPWGAGHNQCLGRAYAVSSIKQFVFLVL
AHFDLELSSPDVEMPEFDLSRYGFGLMQPERDVSIRYRLRA*
CYP8A1 Canis familaris (dog)
XM_543043.2
MVTCFSFTVAGKGVRNRRVLMGAASGVLSGGETGQVVKLAMESE
SEEWALWGGTHMLGIKAPGEDQKRRPGEPPLDLGSIPWLGHALEFGKDAASFLTRMKK
KHGDIFTVLVGGRYVTVLLDPHSYDAVVWEPHSKLDFHAYAVFLMERIFDVQLPHYSP
SDEKAKMKPTLLHKDLQALTDSMYANLRTVLLGDTTEAGSGWHEISLLDFSYSCLLRA
GYLTLYGVEALPRTHESQAQDRAHSADVFHTFRQLDLLLPKLARGSLSAGDKDQACRV
KGRLWKLLSPARLATRAHRSNWLESYLLYLEEMGVSADMQARALVLQLWATQGNMGPA
AFWLLIFLLKNPEALAAVRGEFEQLLSRAEQPISQMTTLPQKLLDNMPVLDSVLSESL
RLTAAPFITREVMVDLAMPMADGREFSLRRGDRLLLFPFLSPQKDPEIYTDPEVFKYN
RFLNSDGSEKKDFYKDGKRLKNYSMPWGAGHNQCLGKAYAISSIKQFVFLVLVHLDLE
LINPDMEIPEFDLSRYGFGLMQPEHDVPVRYRTRP
CYP8A1 rat
GenEMBL U53855(1618bp)
Geraci,M.W., Gao,B., Shepherd,D., Moore,M., Vernon,J., Miller,Y.E.
and Voelkel,N.F.
Nucleic acid sequence of rat prostacyclin synthase
unpublished (1996)
Cyp8a1 mouse
GenEMBL AB001607 AA032426, AA000011, W76862, W13004, W64189
overlapping EST fragments that match best to CYP8A1
MSWAALLGLLAVLLLLLLLLSRRRARRPGEPPLDLGSIPWLGHA
LEFGRDAASFLTRMKEKHGDIFTVLVGGRYVTVLLDPHSYDTVVWELRTRLDFHPYAI
FLMERIFDLQLPNFNPSEEKARMKPTLMHRDLQALTEAMYTNLRTVLLGDSTEAGSGW
QETGLLEFSYNALLSAGYLTLYGVEASPRTHESQAQDRVHSADVFHTFRQLDLLLPKL
ARGSLSAGDKDHACSVKNRLWKLLSPARLASRADRSSWLESYLRHLEEMGVSEEMQAR
ALVLQLWATQGNMGPTAFWLLLFLLKNPEALAAVRAELKHTVWQAEQPVSQMTTLPQK
ILDSMPVLDSVLNETLRLTAAPFITREVMADLALPMADGREFSLRRGDRLLLFPFLSP
QKDPEIYTEPEVFKYNRFLNPDGSEKKDFYKDGKRLKNYNMPWGAGHNQCLGKSYAIN
SIKQFVVLLLTHFDLELGSEDTEVPEFDLSRYGFGLMQPEEDVPIRYRARL
CYP8A1 Xenopus tropicalis (Western clawed frog)
DT406915.1 DN063760.1 cannot extend in ESTdb
29605_prot model missing internal exon(s) UCSC browser
55% to 8A1 human
MVWAGVFSLLLLILCIGFCYYRFLHRTR (2)
QPNEPPLDRGSIPWLGYALEFGKDAAKFLSDMKEKHGDIFT (0)
IQVAGKFITVLLDPHSYDAVFWAPSNQLDFGKYARMLMDRMFDVRLPPSGGNEEKTLLAS (2)
HFQGSNLTKLTRSMFHNLSTILLKDRRLPNTEWTDQGLFDFIYGVMLR (2)
AGYLTLFGTESEQYTSTYSPMRDLKHSEDVYKEFRKLDWLLMKAARNTLST (1)
GEKEEASLVKNRLQKLISIKSHKGKCCKSSWFEYYQQHLEEIQATEDMQSRALVLQLWATQ (0)
GNAGPATFWLVLYLLKHPEAMAAVQAEFESIFQRNLQEKRHIEEMNQDLLDKMIIL (1)
DNVLNETLRLTAAPFISREVLTDMTLKLADGHQYQLRRGDRLCLFPFVSPQMDPEVHQQPE (0)
VFQHNRFLNADGTEKTEFYKKGKRLKYYNLPWGAGSNVCVGKKHAVNSIKQ (2)
FVCLLLFYFDFELKTPAEKIPEFNRTRYGFGLLQPEHDILFRYRRKA*
CYP8A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP8A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_4451
55% to 8A1 human over 423 aa
MIWTVLLLVHALLLYFILRHRSR 15761 (2)
NEPPLDKGLIPWLGHALEFGKDASKFLERMKRKHGDIFT 15636 (0)
VRAAGRYVTVLLDPHSYDQVIHDQDCLDFHSYAKVLMERIFQLRLPNHEPAKEKAVMTQ (2)
15682 HFLGMNLCGLNSSMSRHMLEVAKAEMPQNQKDWKEDGLFNLSYSLLFK 15539
VGYLTLFGGEQNNNCSDLASIYEEYKKFDGLLTKMARGTLKS (1)
YEKKTAQSARQRLWELLAPARLAKGSGSTPWLHAYRRLLREEGVDNEMQTRALLLQLWATQ (0)
GNVGPAAFWMLGYLLTHPEALTAVKTEMEALQLSPLDSSVVTPVF (1)
DSALDEALRLTAAPFITREVLQDKVLHMADGQQYLLRKGDRVCLFPFISPQMDPEIHQEPQ (0)
12256 KYKFNRFLNEDGSVKKDFYKGGRRLKYYSMPWGAGANGCVGKQFAISTMKQ 12107 (2)
YIYVLLTNYDLELCDPCALMPGVNASRYGFGMLQPEGDLLVRYRPRQKL*
CYP8A1 Tetraodon nigroviridis (freshwater puffer)
54% to CYP8A1 zebrafish, 80% to CYP8A1 fugu
MI & WAVLLLVHLLLLYFVVTRRSR (2)
SKNDPPLDKGLIPWLGHALEFGQDAAKFLSRMKRKHGDIFTVRAAGRYVTVLLDPHSY DPVIHNQDSLDFHRYAQVLMERIFLLQLPNYQPDKEKAVMKQ (2)
HFLGKNLSALNSTVSKHMHNLLKTEMPQNQKDWKEDGLFNLSYSLLFK (2)
VGYLTLFAGEQSSDSSHLAVVYEEFKKFDGLLTKLARGTLKS (1)
ADEKKTAQSVRQRLWRLLAPAALTGGLGSTPWLDGYRQVLKEEGADDEMQARALLLQLWATQ (0)
GNVGPAAFWLLGYLLTNPEALAAVKTEMEALRLPPLDSSVSTPVL (1)
DSALDETLRLTAAPFITREVLQDTPLHMADGQQFVLRKGDRLCLFPLISPQMDPEIYQEPQ (0)
KYKFNRFLNEDGSVKKDFYKGGKRLKYYNMPWGAGLNGCMGKEVAITTLKQ (2)
FTYMILTQYDLELCNPRAQIPAVDVSRYGYGMVQPEGDLLVRYKPKKTF
CYP8A2 Fugu rubripes (pufferfish)
No accession number
Scaffold_5061
48% to 8A1 human over 491 aa
MIWAALLGGLLTLVLLYFSRRR (2)
15028 QDNEPPLDKGALPWLGHALEFGRDAAKFLARMKEKHGDVFT 14906 (0)
14562 VRVAGQYITVLLDANSFDSVLNDTVSLDFVKSKNQLLERIFFLKLPGLQPAAEREWMEQ 14389 (2)
14306 HFHGFRLSNLSGTMKANIESLLLSDVKGGSASGWRQDGLFNFCYSLLFR 14163 (2)
AGYLTLFDSADNVTAIYKEFRKFDKLLSKLVRGSLKK (1)
GETHTVNSSRKRLWELLSADWLSRASGSISWQQSYNRFLEKEGVDMEMQRRASLLQLWTTQ 13707 (0)
CNNGPAAFWLLGFLLTHPEAMEALKSEIRQFNLQDPAVRHRTSGSPDSRRTPVF 12379 (1)
12150 DSILSETLRLTAAVLISRVVVGDKVLRMASGQQYKLRRGDKAILFPFLSPQMDP 11989 (frameshift)
EIHLEPQ (0)
11610 SFKYDRFLNIDMSMKDTFYKNEGRLKYYTMPWGAGRHACVGKEFAVATIKQ 11458 (2)
10998 FVFFILTHFDLETCDPQAKLPPVNPSRYGLGMLQPEGELQVRYRLKRSQPET* 10840
CYP8A2 Tetraodon nigroviridis (freshwater puffer)
chr11 4876258-4880369 (+) strand
ortholog to CYP8A2 fugu, 79% to CYP8A2 fugu,
MIWAALLGITGILTLVLLFFSRTR (2)
QENEPPLDKGALPWLGHALEFGRDAAKFLARMKEKHGDVFT (0)
VRVAGQYVTVVLDANSFDSVVNDTVSLDFISSKNQLLERIFHLKLPGLQPAAEREWMER (2)
YFQGCRFAKLCQTMKANIESLLLGEVQGSSASEWKQDSLFSFCYSLLFR (2)
AGYLTMFESTGNANVVYEEFRKFDQLLPKLAQGSLKK (1)
EESQTVNSSRERLWKLGSADWLSQGSGPLSWQQSYLRFLHEEGVGAEMQKRASLLQLWTTQ (0)
CNNGPAVFWLLAFLLTHPEAMEALKSEIRRLNLQDPSGHHLTSNSLELYHTPVF (1)
DSILSETLRLTAAVLIKRVVVEDKVLQMASGQRYKLRRGDKVILFPWLSPQMDPEIHPEPQ (0)
SFKFDRFLNNDRSVKDKFYKNERRLKYYTMPWGAGRHACIGKEFAIATIKQ (2)
FVFFILTHFDVKKLEPQAQLPPVNPSRYGFGMLQPDGDLQVQYRLKRSQSET*
CYP8A3P Fugu rubripes (pufferfish)
Scaffold_11168 Length = 7738 60% to CYP8A2
347 (2) RDNEPPLVMGWIPFVGKAVEFGRDAQGFLLQQKKKFGDVFT 225 (0
8B Subfamily
CYP8B1 rabbit
GenEMBL Y08269
Eggersten, O., Olin, M., Andersson, U., Ishida, H., Kubota, S.,
Hellman, U., Okuda, K.-I. and Bjorkhem, I.
Molecular cloning and expression of rabbit sterol 12 alpha-hydroxylase.
J. Biol. Chem. 271, 32269-32275 (1996)
erroneously called CYP12 in this paper. CYP12 is an insect sequence.
CYP8B1 human
GenEMBL AF090318
Gafvels,M., Olin,M., Chowdhary,B., Raudsepp,T., Andersson,U.,
Persson,B., Jansson,M., Bjorkhem,I. and Eggertsen,G.
Structure and chromosomal assignment of the sterol
12-alpha-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic
cytochrome P-450 gene devoid of introns.
Genomics 56, 184-196 (1999)
CYP8B1 Pan troglodytes (chimpanzee)
XM_001140682.2
98% to human CYP8B1
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPWEPPLDKGTVPWLG HAMAFRKNMFEFLKRMRTKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQY AKKLVLKVFGYRSVQGDHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLTSKGSSLD ASCWHEDSLFRFCYYILFTAGYLSLFGYTKDKEQDLLQAGELFMEFRKFDLLFPRFVY SLLWPREWLEVGRLQRLFHKMLSVSHSQEKEGISNWLGNMLQFLREQGVPSAMQDKFN FMMLWASQGNTGPTSFWALLFLLKHPEAIRAVREEATQVLGEARLETKQSFAFKLGAL QHTPVLDSEVEETLRLKAAPTLLRLVHEDYTLKMSSGQEYLFRHGDILALFPYLSVHM DPDIHPEPTVFKYDRFLNPNGSRKVDFFKAGKKIHHYTMPWGSGVSICPGRFFALSEV KLFILLMVTHFDLELVDPDTPLPHVDPQRWGFGTMQPSHDVRFRYRLHPTE
CYP8B1 Macaca mulatta (rhesus monkey)
AC198108.4
96% to human 8B1
MVLWGPVLGALLVVIAGYLCLPGMLRQRRPREPPLDKGTVPWLGYAMAFRKNMFEFLK
RMRSKHGDVFTVQLGGQYFTFVMDPLSFGPILKDTQRKLDFGQYAKKLVLKVFGYRSVQG
DHEMIHSASTKHLRGDGLKDLNETMLDSLSFVMLKSKGWSLDASCWHEDSLFHFCYYILF
TAGYLSLFGYTKDKEQDLLQAGELFVEFRKFDLLFPRFVYSLLWPQEWLEVGRLQRLFHK
MLSVSHSQEKEGISNWLCNMLQFLREQGVPSAMQDKFNFMMLWASQGNTGPTSFWALLFL
LKHPEAIRAVRQETTQVLGEARLETKQSFAFKLSALQHTPVLDSVVEETLRLRAAPTLLR
LVHEDYTLKMASGQEYLFRRGDILALFPYLSVHVDPDIHPEPTIFKYDRFLNPNGSRKVD
FFKAGKKIHHYTMPWGSGVSICPGRFFALSEVKLFILLMVTHFDLELVDPDTPLPHVDPQ
RWGFGTMQPSHDVRFRYRLRPIV*
CYP8B1 Sus scrofa (pig)
AJ488932, NM_214426
Lundell,K. and Wikvall,K.
Gene structure of pig sterol 12alpha-hydroxylase (CYP8B1) and
expression in fetal liver: comparison with expression of
taurochenodeoxycholic acid 6alpha-hydroxylase (CYP4A21)
Biochim. Biophys. Acta 1634 (3), 86-96 (2003)
Submitted to nomenclature committee August 26, 2002
81% to CYP8B1 human
MVLWGPVLGVLLVAIVGYLCLQGLLRQRRPEEPPLDKGSVPWLG
HAMTFRKNMLEFLKHMWARHGDIFTVQLGGQYFTFVMDPLSFGPILKDAKRKLDFVEY
AEKLVLKVFGYRSMQGDHRMIHSASTKHLMGDGLEELNKAMLDNLSLVMLGPKGPSPD
ASCWREDGLFHFCYDILFKAGYLSLFGRTEDKEQDLLQAEELFMQFRKFDRMFPRFVY
SLLGPREWLEVGRLQCLFHKMLSVEHSLERHGISSWITDMLQVLREQGVAPAMQDKFN
FMMLWASQGNTGPTTFWALLFLLKHPEAMRAVREEATRVLGEARLEDKQSFDVEVSAL
NHMPVLDSVMEETLRLGAAPTLLRVVNSDQILKMASGQEYRLRHGDILALFPYLSVHM
DPDIHPEPTTFKYDRFLTPSGSRKVNFYKAGKKIHHYTMPWGSGISICPGRFFALTEM
KLFVLLMVTHFDLELVDPDTPVPPVDPQRWGFGTMQPSYEVRFRYRLRPTE
CYP8B1 Bos taurus (cow)
See cattle page for details
MVLWGPALGALLVAIVGYLCLRGLLRQRRPKEPPLDKGPVPWLGHAMAFRKNMFEFLRHM
QAKHGDIFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVEYAQKLVLKVFGYRSVQGDY
RMIHSASTKHLMGEGLEELNKVMLDTLSLVMLGPIGPSLGTHHWREDGLFHFCYNILFKA
GYLSLFGYTKDKEQDLLQAEELFLEFRKYDRLFPRFVYSLLGPREWLEVGRLQRLFHKEL
SVEHNLEKYGVSNWITYMLQFLREQGVSPAMQDKFNFMMLWASQGNTGPTSFWALLFLLK
HPEAMRAVREEATRLLGEVRLEAKQSFKFGALHHMPVLDSVMEETLRLRASPTLLRVV
NDDQILQMASGQEYMLRNGDILALFPYLSVHMDPDIXXXXXXXXXXXXXXXXXLL
KAGKKIRHYTMPWGSGVSICPGRFLALNEMKLFILLMVMNFDLELVDPATPVPPVDPQRW
GFGTTQPSHEVRFRYRLRPAE
CYP8B1 horse
XM_001501428.1
86% to pig 8B1
MVLWVPVLGVLLVAIVGYLCVLGLLRQRRPQEPPLDKGSIPWLG
HAVAFRKNMFEFLKHMWAKHGDVFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVEY
AEKLVLKVFGYHSVQGDHRMIHSASTKHLMGDGLEDLNKVMLDSLSLVILGPTGRSPD
ASCWREDGLFHFCYDILFKAGYLSLFGYTKDKEQDLLQAEELFIHFRKFDCLFPRFVY
SLLWPREWLEVGRLQRLFHKTLSVKHNLEKDGISNWISYMLQFLREQEVAPAMQDKFN
FMMLWASQGNTGPTSFWALLFLLKHPEAMRAVRKEATRVLGEARLEARQSFNFKVSAL
HHTPVLDSVMEETLRLGAAPTLLRVVHGDHTLKMASGQEYRLRSGDIVALFPYLSVHM
DPDIHPDPTAFKYDRFLNPNGSRKVAFYKAGKKIHHYTMPWGSGVSICPGRFLALSEM
KLFILLMVTHFDLELVDPDTPVPPVDPKRWGFGTTQPSHDVRFRYRLQPTE
CYP8A1 Canis familaris (dog)
XM_542738.1
84% to pig 8B1
MVFWGLVLGALLVVTTGCLYLLGVLRQRRPQEPPLDKGSIPWLG
HAMAFRKNMFEFLKHMWAKHGDVFTVQLGGQYFTFVMDPLSFGPILKDAQRKLDFVKY
AEKLVLKVFGYHSGQGDYRMIHSASTKYLMGDGLEDLNKTMLDSLSLVMLGPTGQSLD
SSCWHEDGLFHFCYNVLFKAGYLSLFGYTKDQEQDLRQAEELFVQFRKFDRLFPRFVY
SLLGPREWREVGRLQRLFHKALSVKRNLEKNGISRWISYMLQYLRERGVAPAMQDKFN
FMMLWASQGNTGPTSFWALLFLLKHPEALRAVREEATQVLGEARLKARQSFDFKVSTL
HHTPVLDSVMEETLRLGAAPTLLRVVHNDHILKMASGQEYLLRSGDIVALFPYLSVHM
DPDIHPEPTTFKYDRFLNPNGSRKVDFYKAGKKIHHYTMPWGSGVSICPGRFLATNEM
KLFVLLMVTYFDLELVDPNTPVPPVDPQRWGFGTTQPSHEVRFRYRLRPTS
Cyp8b1 mouse
GenEMBL AF090317
Gafvels,M., Olin,M., Chowdhary,B., Raudsepp,T., Andersson,U.,
Persson,B., Jansson,M., Bjorkhem,I. and Eggertsen,G.
Structure and chromosomal assignment of the sterol
12-alpha-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic
cytochrome P-450 gene devoid of introns.
Genomics 56, 184-196 (1999)
MTLWCTVLGALLTVVGCLCLSLLLRHRRPWEPPLDKGFVPWLGH
SMAFRKNMFEFLKGMRAKHGDVFTVQLGGQYFTFVMDPLSFGPIIKNTEKALDFQSYA
KELVLKVFGYQSVDGDHRMIHLASTKHLMGQGLEELNQAMLDSLSLVMLGPKGSSLGA
SSWCEDGLFHFCYRILFKAGFLSLFGYTKDKQQDLDEADELFRKFRRFDFLFPRFVYS
LLGPREWVEVSQLQRLFHQRLSVEQNLEKDGISCWLGYMLQFLREQGIASSMQDKFNF
MMLWASQGNTGPTCFWVLLFLLKHQDAMKAVREEATRVMGKARLEAKKSFTFTPSALK
HTPVLDSVMEESLRLCATPTLLRVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMD
PDIHPEPTAFKYDRFLNPDGTRKVDFYKSGKKIHHYSMPWGSGVSKCPGRFFALSEMK
TFVLLMIMYFDFKLVDPDIPVPPIDPRRWGFGTSQPSHEVRFLYRLKPVQ
CYP8B1 rat
NM_031241.1
89% to mouse 8b1
MLWGSVLGALLMAVGCLCLSLLPRHRRPWEPPLDKGFVPWLGHT
MAFRKNMFEFLKGMRAKHGDVFTLQLGGQYFTFVMDPLSFGPIIKSTQKVLDFVTYAR
ELVFKVFGYQSMDEDHQMLHVASTKHLMGQGLEDLNRAMLDSLSLVMLGPKGRSLGAR
SWCEDGLFHFCYSILFKAGFLSLFGCTKDKEQDLDEADELFRKFRRFDLLFPRFVYSL
LGPLEWVEVSQLQRLFHQRLSVEQNLEKDGISNWLGFMLRFLRERGMASSMQDKFNFM
MLWASQGNTGPTCFWALLFLLKHQDAMKAVREEATRVLGEARLEAETSFAFTLSALKC
TPVLDSVMEETLRLCATPTLLGVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMDP
DIHPEPTTFKYNRFLNPDGTRKVDFYKSGKKIHHYNMPWGSGVSICPGRFFAPSEMKT
FVLLMVMYFDFELVDPDMPVPPIDPRRWGFGTSQPSHEVRFRYRLKPMQ
CYP8B1 Monodelphis domestica (gray short-tailed opossum)
XM_001377081.1
48% to 8B1 human
MALWVFVFIILVSSVLVVLYALGVLRQRRAREPPLDKGPIPWFG
YTWHLSKDASSFLKKMHRRYGNIFTILLGGKYVTFVTDPLSFDAILKENRSKLDFSNF
ASQLVFKIFEFQGPKQYQKVLKSHSTKYLMGSSLAVMTQAMMDNLQVLLLELDADMKP
GLQEWKQDGLLEHCYNIVFRAGYLALFGSLPTSGKSGHIQDLLRSQKVFEEFRKFDRL
FPRAFLSALLPNEKQEMKRLRRFFWDILAPQKILEKDNVSPWIYFSQQQLADSGVSDI
GQSQNNLILLWASQGNTGIVSFWALLFLLKNPGALKAVREEAEGILRKMGKERRPGGV
PIQVEYSMLQQTPVLDSVMEETLRLVVAPFLTRSVMQDMILKMDDGREYALRKGDEVC
VFPYLFLHMDPEIYPDPTTFKYDRFLNLDGSQKVDFYKQGRRIKSYMLPWGAGPSLCP
GRFFALNEMKMFVFLMVTQYDIELVDQEVEIPPINVKRWGIGAMQPIYDVQFRYRIKP
LKSRAKAETSKVEWCWTMETLEN
CYP8B1 chicken
NM_001005571.1
59% to 8B1 Fugu
MTFWAVFLCTLAVSLLGGLYVLGTFRRRRPNEPPLDKGIIPWLG
YALDFRQDSSGFLSKMQRKHGDIFTVLIGGHYFTFVMDPFCFGAIVKESRSKLDFLTF
AAKLVLRVFGYKSNKDNNSALHSFNTKHLMGEGLSLLTQATMDNFQKLMLFKLSSGEE
KQPWQEAGLFHYCYNIVFRAGYLALYGTESYQGTGNKEKAHEQDLIHSNQLFTEFRKY
DRLFPRLAYAVLPPKDKVEAERLKRFFWDALSVSKDSQKENVSRWISEQDQYLAESGV
PDYMRDRFKFMMLWASQGNTGPTAFWLLLYLMKDPEAMKAVKGEVEKVLREHGQEVKP
GSPPVNITRDMLDQTPFLDSAVEETLRLVAAPILIRAVLQDVNLKMSSGREYTLRKGD
RVALFPHLSVQMNPEIHPEPHKFKYDRFVNPDGTKKDFYKNGKRLKYFNMPWGAGVST
CPGRFFATAEMKLFVFLMLTHYDLELVNDKEEIPAIDSSRWGFGTMQPVHDVRFRYRP
RV
CYP8B1 Xenopus tropicalis (Western clawed frog)
CX973251.1 cannot extend in ESTdb
Trace archive 413359888 234313629 248374609 continues on CF343441.1
54% to human CYP8B1, an 8B1 ortholog
MALFLPIILALLVSVIGGLYLLGMFRKRRPDEPPLDKGTIPWLGYALDFRKNTSTFLQKMHKK
HGDIFTVQIAGYYFTFVMDPLSFGPIIKESKGNLDFEEFAKDLVLRVFGYQSFTNDHKML
EKSSTKHLMGDGLIVMTQAMMENLQNLMVHNIGSGKGEREWQQDGLFNYSYNIVFRAGYL
ALYGNEPAKNKGSKEKAKEFDRKHSDELFYEFRKYDQLFPRLAYAVLPPKDKIEAERLKR
LFWNMLSVKKTLQKENISGWIGEQHQ
QRAEQGLPEYMQDRFMFLLLWASQGNTGPASFWFLLYLLKHPEALKAVREEVEAVLKETG
QEVKPGGPLINLTRDMLMKTPVMDSAVEETLRLTAAPVLIRAVKQDMKIKMASGKDFSMR
KGDRVALFPYIAVQMDPEIHAEPEKFKYNRFLNEDGTKKTEFFKNGKKVKYYTMPWGAGS
TICPGRFFATNELKQFAFLMLTYFEFELVNPNEEIPSIDPNRWGFGTMQPTRDVQFRYRLRY*
CYP8B1 Xenopus laevis (African clawed frog)
BU908175.1, EG582632.1 DT064227.1 BX850755.1
53% to human CYP8B1
MALFFPIILALLASVIGGLYLLGMFRKRRSDEPPLDKGTIPWLGYALDFRKSTSNFLQKMHKKHGDIF
TVQIAGYYFTFVMDPLSFGPIIKESKANLDFEEFARELVSRVFGYQSVTHGHKMLEKSST
KHLMGDGLVVMTQAMMENLQNLMVHNIGSSKGEREWHQDGLFNYSYNVVFRAGYLALYGN
EPAKNKGKEKAKEFDRTHSDELFYEFRKYDQLFPRLAYSVLPPKDKIEAERLKRLFWNML
SVKKTLQKENISGWIGEQHQQRAEQGMPEHMQDRFMF
LLLWASQGNTGPASFWFILYLLKHPEAMRAVREEVEAVLKETGQEVKPGGPLINLTRDML
MKTPVMDSAVEETLRLTAAPVLIRAVKQDMKIKMASGNDFSIRKGDRVALFPYIAVQMDP
SIRKGDRVALFPYIAVQMDP
EPEKYKYNRFLNEDGTKKTDFFKNGKKVKYYTMPWGAGSTICPGRFFATNELKQFVFLML
TYFEFELVNPDEEIPGIDPNRWGFGTMQPTHDVQFRYRLRY*
CYP8B1 Danio rerio (zebrafish)
CU694226.12 LINKAGE GROUP 2 72852-74384 (+) STRAND
NO HIT IN UCSC BROWSER BUT CYP8B1, CYP8B2 and CYP8B3 ARE ADJACENT
On CU694226.12
MALVQILLALLISVIGALYLLGSFRRRRTGEPPLEKGPIPWLGHVLEFRKDTAKFLNRM KAKHGDIFTVQLGGFYFTFITDPLSFGAVVKEARAKLDFTKFAEQLVQRVFGYHSIQSE HKVLQASSTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYSYNIVFR AGYLSLFGNESPKGTGKESVEKAKEIDRQESNDLFWEFRKYDQLFPNLAYGVLGPSEKM EAERLKRLFWSTLSVQKMRARDNISGWVSDQQQVRAEHGMQEFMQDRYMFLLLWASQGN TGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTPILDS AVEETLRLTAAPILTRAVMQDMTIIMANGQEYKIREGDRVAVFPYVVHVDPEVHPDPLT FKYDRFLNADGSRKTDFYKGGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYF DFELTNPNEQIPGIDIRRWGFGSMQSDRDIQFRYRPRI
CYP8B1 Takifugu rubripes (pufferfish)
No accession number
Scaffold_7782
50% to 8B1 human
this seq is older than the UCSC browser assembly
Takifugu rubripes v4.0 (Oct. 2004) (JGI 4.0/fr2)
4794 MASVLLILLTFLVALLGGLYLLGVFRQRRPGE
4890 PPLDKGLIPWLGHVLEFRRNTWRFLERMEKKHGDVFTVQLAGFYITFIQDPMSFGAFVKE 5069
5070 SREKLDFRKFASHLVRRVFGYSSIQNDHDILNASSNRHLKGDGLEVMTQAMM 5225
5226 VNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRAGYLSLYGNEPFDSKISQEKAKEKD 5405
5406 RAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATKLLEYFWNVLSVQKLKGRD 5567
5568 NISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSSFWLLLFL
MKHPEAMRSVKEEIDKVVRESGQEVKPGGPLVNLSREMLMKTPIL
DSAVEETLRLTAAPLLTRAVLQDMTLKMADGQQYFIRQGDRVALFPYSAIQMDPEIHPDPR
SFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQ
FAFLMLLYFEFELINPDEEIPEIDYSRYGFGTMQPDRDLQFRYRLRY* 6329
Note: The UCSC browser has three intact and three partial CYP8B sequences
in Takifugu rubripes v4.0 (Oct. 2004) (JGI 4.0/fr2) assembly
CYP8B1a Takifugu rubripes (pufferfish)
UCSC Browser chrUn:138771800-138773332 (+) strand 129kb downstream
USP14 THOC1 AQP1 CYP8B1b (other) CRHR2 MYL6 PTHR1 CCDC13 HIGD1A
CYP8B1a (this one) GJA12/CX47.1 JMJD4 WNT9A
3 aa diffs to our CYP8B1 fugu (old version shown above)
note human CYP8B1 is next to CCBP2 HIGD1A CCDC13
this gene is syntenic with Tetraodon CYP8B1a
MASVLLILLTFLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYSSIQNDH
EILNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRA
GYLSLYGNETFDSKISQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSVQKLKGRDNISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSS
FWLLLFLMKHPEAMRSVKEEIDKVVRESGQEVKPGGPLVNLSREMLMKTPILDSAVEETL
RLTAAPLLTRAVLQDMTLKMADGQQYFIRQGDRVALFPYSAIQMDPEIHPDPRSFKYDRF
LNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLYFEFELINP
DEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY*
CYP8B1a-de1b Takifugu rubripes (pufferfish)
UCSC browser chrUN 138769130-138769446 (+) strand
Scaffold_20802 Length = 2432 9 diffs with Scaffold_7782
C-term 2.3 kb upstream of CYP8B1a
Called CYP8B3P in P450 Blast server
DIAGAKEDMINRFISRYMFVLFWASWGNTGPSSFWLLLFL
MPWGSGISMCPGRFFATNELKQFAFLMLLYFEFELINPDLEIPEIDYSRYGFGTTQPD*D
LQFRYRSRY
CYP8B1-se1[1] Takifugu rubripes (pufferfish)
chrUn:392992722-392993066 (-) strand UCSC browser
ZNF511 MED12 (this seq) NOTCH1 CCDC57
Solo exon, 1 aa diff to CYP8B1c fugu
FXYSAVQMDPEIHPDPHSFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRF
FATNELKQFAFLMLLYFEFELINPDEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY
CYP8B1a Tetraodon nigroviridis (freshwater puffer)
UCSC browser chr 15 1216631-1218163 (-) strand
98.9% to CYP8B1b
94 kb downstream
MAPLLLILLTLLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWKFLDRM
KQKHGDVFTIQLAGFYITFIQDPMSFGAFVKESRDKLDFRKFAAHLVYRVFGYITVEGDH
ESLNTSSNRHLKGDGLEVMTQAMMSSLQNLMLHNVGPCSDHMTWREDKLFAYCYNIVFRA
GYLSLYGNEPFNSNISEEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSIQKVKSRDNISRWIWDVQESKDNAGVKEDMLSRYMFVLLWASQGNTGPSS
FWLLLFLMKHPEALRAVKEEINKVVRESGQEVKRGGPLVNLSREMLMKTPILDSAVEETL
RLSAAPLLTRAVLQDMTINMADGKKYFIRQGDRVALFPYSAVQMDPEIHPDPHSFKYDRF
LNPDGSEKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLYFELELINP
DEEIPEMDQSRYGFGTMQPDRDVQFRYRLRY*
CYP8B1a-de1b Tetraodon nigroviridis (freshwater puffer)
UCSC browser chr 15 1212312-1212371 (-) STRAND
N-TERM FRAG 4 kb downstream from CYP8B1a
LLILLALLVALLGGLYLLGV
CYP8B1a-de1c Tetraodon nigroviridis (freshwater puffer)
UCSC browser chr 15 1206903-1207616 (-) strand
97.9% to CYP8B1a
9 kb downstream of CYP8B1a
MAPLLLILLTLLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWKFLDRM
KQKHGDVFTIQLAGFYITFIQDPMSFGAFVKESRDKLDFRKFAAHLVYRVFGYITVEGDH
ESLNTSSNRHLKGDGLEVMTQAMMSSLQNLMLHNVGPCSDHMTWREDKLFAYCYNIVFRA
GYLSLSGNEPFNSNISEEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREA
CYP8B1b Tetraodon nigroviridis (freshwater puffer)
UCSC browser chr 15 1311319-1312851 (-) strand
98.9% (6 aa diffs) to CYP8B1a Tetraodon
ROCK2 ROCK1 USP14 THOC1 AQP1 CYP8B1c CRHR1 MYL6 PTHR2 CCDC13
HIGD1A CYP8B1b CYP8B1a GJA12 JMJD4
The very high percent identity between 8B1a and 8B1b
Indicates a very recent duplication.
Based on synteny CYP8B1a is the ortholog of CYP8B1a in fugu,
But CYP8B1b is not orthologous to CYP8B1c in fugu.
MAPLLLILLALLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWKFLDR MKQKHGDVFTIQLAGFYITFIQDPMSFGAFVKESRNKLDFRKFSAHLVYRVFGYITVEG DHEGLNTSSNRHLKGDGLEVMTQAMMSSLQNLMLHNVGPCSDHMTWREDKLFAYCYNIV FRAGYLSLYGNEPFNSNISEEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQR EATKLLEYFWNVLSIQKVKSRDNISRWIWDVQESKDNAGVKEDMLSRYMFVLLWASQGN TGPSSFWLLLFLMKHPEALRAVKEEINKVVRKSGQEVKRGGPLVNLSREMLMKTPILDS AVEETLRLSAAPLLTRAVLQDMTINMADGKKYFIRQGDRVALFPYSAVQMDPEIHPDPH SFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLY FELELINPDEEIPEMDQSRYGFGTMQPDRDVQFRYRLRY
CYP8B1c Takifugu rubripes (pufferfish)
chrUn:138640517-138642049 (+) strand UCSC browser
4 aa diffs to CYP8B1a fugu,
this is a very recent duplication of fugu CYP8B1a.
It is not the ortholog of zebrafish CYP8B2 or CYP8B3,
or Tetraodon CYP8B1a or CYP8B1b.
This gene is not syntenic with any Tetraodon seq
MASVLLILLTFLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYSSIQNDH
DILNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRA
GYLSLYGNEPFDSKISQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSVQKLKGRDNISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSS
FWLLLFLMRHPEAMRSVKEEIDKVVRESGQEVKPGGPLVNLSREMLMKTPILDSAVEETL
RLTAAPLLTRAVLQDMTLKMADGRQYFIRQGDRVALFPYSAVQMDPEIHPDPHSFKYDRF
LNPDGSKKTDFYKAGNKVKYYTMPWGSGISMCPGRFFATNELKQFAFLMLLYFEFELINP
DEEIPEIDYSRYGFGTMQPDRDLQFRYRLRY*
CYP8B1v1 Petromyzon marinus (sea lamprey)
Assembled from trace files
97% identical to ver 2 (alleles)
note: CYP8B seems to be derived from CYP7A by whole genome duplication
CYP8A is not found in lamprey and probably arose later from an 8B
Duplication.
Probable role in making petromyzonol and
the pheromone petromyzonol 24-sulfate.
MAGLVLFASSCVVGLLVIIGLVLFVTRRSQ (2)
HPGEPPLDKGLIPWLGHAIEFRRNMYTFLRRMQRKHGDVFT (0)
VCLGGEYITFMLDPHDVAAVAREPRSALDFKAFARQFVLIVFGVNIKVEYPKVTSALNVS (2)
HLQGDGLVAMTDAMMSQLHLLMGPGSFNEGNGRGGCGGHGDAKWHESGLFDFCYGIVFR (2)
AGYLALFGQEPGGPARQTTHSLEVFKEFRKYDQLFPAIATSTLWP (1)
AQRKEADRLKSWFWEHLTVSLLRVREHVSPWILGRDEKLAELQADKETRDRTLFMLLWASQ (0)
GNTGPAAFWTLAYLMKHADAMAAVRAEVQQLLEATGQSDGAETREISLTRDMLVNTPVL (1)
DSVIEEMLRLRSAPILVRAVQQDMTLQVPGASGPGTKLRAGDRLAMFPHLSPHMDPEVHANPE (0)
EFKFDRFLNEDGSKKTDFFKSGRKLRYPTMPWGAGVSICPGRFFATNEIKQ (2)
FIVLMLIHYDVELSDPTTKVPDINVSRFGFGVMHPTHEISFRYRPRF*
CYP8B1v2 Petromyzon marinus (sea lamprey)
Assembled from trace files
97% identical to ver 1 (alleles)
note: CYP8B seems to be derived from CYP7A by whole genome duplication
CYP8A is not found in lamprey and probably arose later from an 8B
Duplication.
Probable role in making petromyzonol and
the pheromone petromyzonol 24-sulfate.
MAGLVLFASSWVVGLLVIIGLVLFVTRRSR (2)
HPGEPPLDKGLIPWLGHAIEFRRNMYTFLRRMQRKHGDVFT (0)
VCLGGEYITFMLDPHDVAAVAREPRSALDFKAFARQFVLIVFGVNIKVEYPKVTSALNVS (2)
HLQGDGLVALTDAMMSQLHLLMGPGSFNEGNGRGGCGGHGDAKWHESGLFDFCYGIVFR (2)
AGYLALFGQEPGGPARQTTHSPGVFKEFRKYDQLFPAIATSTLWP (1)
AQRKEADRLKSWFWEHLTVSLLRVREHVSPWILGRDEKLAELQADKETRDRTLFMLLWASQ (0)
GNTGPAAFWTLAYLMKHADAMAAVRAEVQQLLEATGQSDGAETQEISLTRDMLVNTPVL (1)
DSVIEEMLRLRSAPILMRAVQQDMTLQVPGASGPGTKLRAGDRLAMFPHLSPHMDPEVHADPE (0)
EFKFDRFLNEDGSKKTDFFKSGRKLRYPTMAWGAGVSICPGRFFAANEIKQ (2)
FIVLMLIHYDIEFSDPTTKVPDINVSRFPFGVMHPTHEICFRYRPRF*
CYP8B2 Danio rerio (zebrafish)
chr2:2598909-2600450 100%
CU694226.12 LINKAGE GROUP 2 56515-58059 (-) STRAND 100%
Note there are two P450s next to each other due to a mirror duplication
That includes the flanking gene GJC1
GJC1 8B2 8B3 GJC1 JMJD4
The UCSC browser is missing CYP8B1 but it present in CU694226.12
GENE ORDER on CU694226.12:
CX47.1/GJA12 8B3 41040-42575 (-) STRAND, 8B2 56515-58059 (-) STRAND,
8B1 72852-74384 (+) STRAND
GENE ORDER FROM Zv8 browser: WNT3A MMP16 C1QL3 GPT2 SERP1 CX47.1/GJA12,
8B3 8B2 (8B1 INFERRED FROM CU694226.12) CX47.1/GJA12 SERP1 JMJD4
This location is syntenic with CYP8B1a in Tetraodon
The duplications forming CYP8B2 and CYP8B3 are independent of the
duplications in pufferfish.
MESLVQILLALLLSVIGALYLLGGFRRRRTGEPPLEKGLIPWLGCVLEFRKDTVKFLQR MKAKHGDIFTVQLGGFYFTFITDPQSFGAVVKESRAKLDFT
NFADQLVERVFGYGAVEIKHKFFKNLQTTSTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYSYN IVFRAGYLSLFGNESPKGTGKESVEKAKEIDLQHSNDLFWEFRKYDQLFPNLAYGVLGP RGKMEAERLKRLFWNMLSVQKMKARDNVSGWVSDQQQVRAEHGMQEFMQDRFMFLLLWA SQGNTGPSAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTP ILDSAVEETLRLTTAPLLTRGVMEDMTIIMANGQEYKIREGDRVSVFPYLVHIDPEVHP DPLTFKYDRFLNADGSRKTDFYKDGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLM LSYFDLELKNPNEEIPSIETRRWGFGSMHPDRDIQFRYRPRI
CYP8B2X Fugu rubripes (pufferfish)
No accession number
Scaffold_21917
59% to 8B1 human
renamed CYP8B4
MASLLLILLTFLVALLGALYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFCRNTWRFLERMEKKHGD
VFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYIATKADHEMLNASSNRH
LKGDGLEVMTQAMMINLQNLMLHNVDSSSDRVTWREEKLFAYCYNIVFRAGYLSLYGNEA
FDSKTSQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKRREATKLLEYFWNVLS
VQKLKGRDNISRWIWDVQEGKDNAGVKEDMITR
YMFVLLWASQGNTGPSSFWLLLFLMKHPEAMRSVKEEIDKAVRESGQEVKPGGPLVKMSR
EMLMKTPILDSAVEETLRLTAAPLLTRAVLQDMTLKMADGRQYFIRQGDRVALFPYSAVQ
MDPEIHPDPRSFKYDRFLNPDGSKKTDFYKAGNKVKYYTMPWGSGASMCPGRFFATNELKQFAFLM
LLYFEFELINPDEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY*
CYP8B3 Danio rerio (zebrafish)
chr2:2583434-2584966 1 aa diff
CYP8B3 SEEMS TO BE THE ORTHOLOG OF HUMAN CYP8B1
Revised the N-TERMINAL sequence
93% TO CYP8B2 Danio, 91% TO CYP8B1 Danio
CU694226.12 LINKAGE GROUP 2 41040-42575 (-) STRAND 100%
MESLVQILLALLLSVIGALYLLGGFRRRRTGEPPLEKGLIPWLGCVLEFRKDTVKFLQKM
KAKHGDIFTVQLGGFYFTFITDPLSFGAVVKESRAKLDFTK
FSDQLVERVFGYHPMENEHKF LQTASTKHLMGDGLVVMTQAMMYNLQNLMLHSVGSGNGKVWQESGLFAYCYNIVFRAGY LSLFGNESPKGTGKESVEKAKEIDLQHSNDLFCEFRKYDQLFPNLAYGVLGPRGKMEAE RLKRLFWSTLSVQKMRVKDNISGWISDQQQVRAELDMQEFMQDRFMFLLLWASQGNTGP SAFWLLLYLMKHPEAMSAVRKEVEEILKEAGQEVKPGGPLIDLSRDMLLKTPILDSAVE ETLRLTTVPLLTRGVVQDMTIIMANGQEYKIREGDRVSVFPYLVHIDPEVHPDPLTFKY DRFLNADGSRKTDFYKDGKKLKYYSMPWGAGTTMCPGRFFATNELKQFVFLMLSYFDFE LTNPNEQIPDIDIRRWGFGSMHPDRDIQFRYRPRI
CYP8B4 Takifugu rubripes (pufferfish)
chrUn:372955311-372956843 (-) strand UCSC browser
formerly called CYP8B2
RIOK1 CDYL CARS SPN CYP8B4-de1b, CYP8B4 (this one) MED12-like SOX2
5aa diffs to CYP8B2X fugu (older assembly shown above)
This gene is in a novel location not syntenic to Danio CYP8B1,
CYP8B2 or CYP8B3.
MASLLLILLTFLVALLGALYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFCRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYIATKADH
EMLNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYCYNIVFRA
GYLSLYGNETFDSKISQEKAKEKDRAESEALYHEFRKYDQLFPRLAYGVLPPKKQREATK
LLEYFWNVLSVQKLKGRDNISRWIWDVQEGKDNAGVKEDMITRYMFVLLWASQGNTGPSS
FWLLLFLMKHPEAMRSVKEEIDKAVRESGQEVKPGGPLVKMSREMLMKTPILDSAVEETL
RLTAAPLLTRAVLQDMTLKMADGRQYFIRQGDRVALFPYSAVQMDPEIHPDPRSFKYDRF
LNPDGSKKTDFYKAGNKVKYYTMPWGSGASMCPGRFFATNELKQFAFLMLLYFEFELINP
DEEIPEIDYSRYGFGTMQPDRDLQFRYRRRY
CYP8B4-de1b Takifugu rubripes (pufferfish)
chrUn:372951772-372952290 (-) strand UCSC browser
N-term 3kb downstream
100% to CYP8B1a fugu, 94% to CYP8B4 fugu
This looks like 8B4 was at one time usptream of CYP8B1a
It may have been copied taking a piece of CYP8B1a with it.
MASVLLILLTFLVALLGGLYLLGVFRQRRPGEPPLDKGLIPWLGHVLEFRRNTWRFLERM
EKKHGDVFTVQLAGFYITFIQDPMSFGAFVKESREKLDFRKFASHLVRRVFGYSSIQNDH
EILNASSNRHLKGDGLEVMTQAMMVNLQNLMLHNVDSSSDQVTWREEKLFAYC
9A Subfamily
CYP9A1 Heliothis virescens (tobacco budworm)
GenEMBL U23506 (1763bp)
Randy L. Rose, Doreen Goh, Deborah M. Thompson, Kuldeep D. Verma,
David G. Heckel, Linda J. Gahan, Richard M. Roe, and Ernest Hodgson.
Cytochrome P450 (CYP) 9A1 in Heliothis virescens: The first member of
a new CYP family.
Insect Biochem. Molec. Biol. 27, 605-615 (1997)
CYP9A1v2 Heliothis virescens
no accession number
Satish Pimprale
submitted to nomenclature committee 10/6/98
98% identical to 9A1
CYP9A2 Manduca sexta
GenEMBL AF172278
Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
Inducible P450s of the CYP9 family from larval Manduca sexta midgut
Unpublished
submitted to Nomenclature Committee
sequence revised 4/14/99
CYP9A2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP9A3 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
99% 3 aa diffs to 9A3v2 all in N-term 22 aa
83% to CYP9A1 Heliothis virescens,
note 9A3 of Pittendrigh et al. was a PCR frag
This is the full length sequence
CYP9A3 frag. Helicoverpa armigera (Australian cotton bollworm)
no accession number
Pittendrigh, B., Aronstein, K., Zinkovsky, E., Andreev, O.,
Campbell, B., Daly, J., Trowell, S. and ffrench-Constant, R.H.
Cytochrome P450 genes from Helicoverpa armigera: expression in a
Pyrethroid susceptible and resistant strain. Submitted
hacyp945
submitted to Nomenclature Committee
CYP9A3 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000133 has 1 aa diff to CYP9A3 from Rene Feyereisen
CYP9A3v2 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #10 532 aa HaCypZ003a-v2Pep
Only 4aa diffs in 125aa (not including the ends of 9A3)
CYP9A4 Manduca sexta
GenEMBL AF172279
Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
Inducible P450s of the CYP9 family from larval Manduca sexta midgut
Unpublished
submitted to Nomenclature Committee 3/13/99
sequence (a)
Note: an older sequence was formerly 9A4, but it was renamed to 9E1
this sequence was never public, so the number has been reused.
CYP9A4 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP9A4v2 Manduca sexta
GenEMBL AF172280
Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
Inducible P450s of the CYP9 family from larval Manduca sexta midgut
Unpublished
submitted to Nomenclature Committee 3/13/99
sequence (c)
CYP9A5 Manduca sexta
GenEMBL AF172281
Stevens,J.L., Snyder,M.J., Koener,J.F. and Feyereisen,R.
Inducible P450s of the CYP9 family from larval Manduca sexta midgut
Unpublished
submitted to Nomenclature Committee 3/13/99
sequence (b)
CYP9A6 Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
No accession number
Weimin Li and May Berenbaum
submitted to nomenclature committee 10/15/02
52% to 9A1 missing from PERF to end
CYP9A7 Depressaria pastinacella (Lepidoptera: Oecophoridae) (parsnip webworm)
No accession number
Weimin Li and May Berenbaum
submitted to nomenclature committee 10/15/02
67% to 9A6 N-terminal 134 aa piece only
CYP9A8 Spodoptera litura (common cutworm)
GenEMBL AF525031.1
Chang,C.-K., Wu,M.-C. and Lu,K.-H.
Cloning of cytochrome P450 gene in the larva of common cutworm,
Spodoptera litura
Unpublished
CYP9A9 Spodoptera exigua (beet armyworm)
No accession number
Kei Shimada
submitted to nomenclature committee 7/14/03
89% to CYP9A8, 78% to 9A10, 56% identical to CYP9A4
clone name sequence #1
CYP9A10 Spodoptera exigua (beet armyworm)
No accession number
Kei Shimada
submitted to nomenclature committee 7/14/03
79% to 9A8, 78% to 9A9, 56% identical to CYP9A4
clone name sequence #2
CYP9A10 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee Jan. 27, 2005
Clone name S4-1
80% to 9A13, 79% to 9A8, 64% to 9A23
2 amino acid diffs compared to Shimadas seq.
CYP9A11 Spodoptera exigua (beet armyworm)
No accession number
Kei Shimada
submitted to nomenclature committee 7/14/03
65% identical to CYP9A8, 64% to 9A10, 53% to 9A1
clone name sequence #3
CYP9A11 Spodoptera exigua (beet armyworm)
No accession
Katsuya Natsuhara
Submitted to nomenclature committee Jan. 27, 2005
Clone name S4-4
66% to 9A13, 79% to 9A8, 64% to 9A22
4 amino acid insert compared to Shimadas seq.
CYP9A12v1 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL AY371318
Yidong Wu & Song Chen
submitted to nomenclature committee 8/19/03
72% to CYP9A8 57% to partial seq CYP9A3
CYP9A12v2 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Wu Yidong
Submitted to nomenclature committee Dec. 4, 2004
Clone name CYP_Ger
98% to CYP9A12v1
CYP9A12v3 Helicoverpa zea (corn earworm)
No accession
Xianchun Li
Submitted to nomenclature committee Oct. 3, 2005
clone name: P12cDNA-2
probable ortholog to CYP9A12v2 only 13 aa diffs
CYP9A13 Mamestra brassicae (moth)
GenEMBL AY390260
Martine Maibeche
80% to 9A10
submitted to nomenclature committee Sept. 12, 2003
CYP9A14 Helicoverpa armigera
GenEMBL AY487948
Yidong Wu & Song Chen
CYP9A14 Helicoverpa zea (corn earworm)
No accession
Xianchun Li
Submitted to nomenclature committee Oct. 3, 2005
clone name: P14cDNA-1
ortholog of Helicoverpa armigera CYP9A14 only
6aa diffs
CYP9A14 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_261 99% to CYP9A14 AY487948
CYP9A15 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
Note: this seq has two aa diffs to Grubors seq #12
outside Grubors frameshifted region.
The successor to Grubors seq #12 is
HaCypZ001a-v7Pep, but this seq has the two aa diffs
mentioned above and 7 more outside the frameshifted
region that is now corrected.
HaCypZ001a-v7Pep may be an allele of the original #12 seq.
Or it could be a very similar distinct gene.
12 aa diffs to CYP9A15v2
10 aa diffs to CYP9A18, one is in the same codon,
but no mutations are the same.
CYP9A15 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #12
65% to 9A12, 64% to 9A17, 56% to 9A14
Note: the name CYP9A15 refers to the original seq #12
And its full length non-frameshifted version from
Feyereisen. HaCypZ001a-v7Pep must be CYP9A15v2
unless it is a second very similar gene.
CYP9A15 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_191 has 3 aa diffs to 9A15 from Rene Feyereisen Ha_02A22_C
Contig_246 has 3 aa diffs to Contig_191, 100% in first 275aa to Rene
Contig_255 has 1 aa diff to Contig_246
CYP9A15v2 Helicoverpa armigera (Australian cotton bollworm)
No accession number
HaCypZ001a-v7Pep, successor to Grubors seq #12
See comments above.
12 aa diffs to CYP9A15 Feyereisen
3 aa diffs are in Grubors frameshifted region.
CYP9A16 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
only 1 aa diff to CYP9A16 of Grubor,
64% to CYP9A17, 62% to CYP9A12
CYP9A16 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #4 132 aa from C-term HaCypZ007a-v1Pep
70% to 9A13, 70% to 9A14, 67% to 9A12
CYP9A17 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
Note: 1 aa diff to 9A17v2, 3aa diffs to CYP9A17v1
2 of these three diffs are at the extreme C-term in
the last 3 aa so these are probably seq errors.
This seq. represents the consensus seq between the three versions.
CYP9A17 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_200 has 1 aa diff to CYP9A17 Ha_02A22_B from Rene
41% to CYP9J5
CYP9A17v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Cai-Xia Ma
Submitted to nomenclature committee Sept. 14, 2004
This sequence has one aa diff to Vladimir Grubors
CYP9A12v2 fragment over 162 aa.
Therefore, these seem to be the same gene.
This sequence is full length and shows 93% identity to 9A12
It does not look like an allele, so I am renaming 9A12v2
To CYP9A17.
CYP9A17v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
95% to 9A12v1, 8aa diffs in 162aa. Seq #11 HaCypZ002x-v3Pep
from mid region of P450
formerly CYP9A12v2, 1 aa diff to 9A17v1 of Cai-Xia Ma
CYP9A17v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Vladimir Grubor
Submitted to nomenclature committee Dec. 30, 2003
Sequence #17 HaCypZ002y-v2Pep
100% to 9A17v1 of Ma Seq #17
from C-term of P450
CYP9A17v2 Helicoverpa armigera (Australian cotton bollworm)
GenEMBL DQ003275
Wu Yidong
Submitted to nomenclature committee Dec. 4, 2004
Clone name CYP_Fen
94% to CYP12, 4 amino acid diffs to 9A17v1
CYP9A18 Helicoverpa armigera (cotton bollworm)
GenEMBL DQ256408
Yidong Wu and Lina Yue
submitted to nomenclature committee Aug. 13, 2005
clone name YS-QJ-9
96% to CYP9A15, might be an allele of 9A15
21 aa diffs to CYP9A15v2
CYP9A19 Bombyx mori (silkworm)
See Bombyx page
CYP9A19 Bombyx mori (silkworm)
No accession number
Junwen Ai
submitted to nomenclature committee Jan. 31, 2007
identical to sequence CYP9A19 (qq) on Bombyx page
CYP9A20 Bombyx mori (silkworm)
No accession number
Junwen Ai
submitted to nomenclature committee Jan. 31, 2007
identical to sequence CYP9A20 (rr) on Bombyx page
CYP9A21 Bombyx mori (silkworm)
No accession number
Junwen Ai
submitted to nomenclature committee Jan. 31, 2007
nearly identical to sequence CYP9A21 (ss) on Bombyx page except
one short exon does not match.
This exon matches to an adjacent gene sequence on the
genomic sequence AADK01003199. At present we cannot tell
which sequence is accurate and which is chimeric.
CYP9A22 Bombyx mori (silkworm)
See Bombyx page CYP9A tt
CYP9A23v1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
73% to CYP9A17, 71% to CYP9A12, 69% to 9A18, 67% to 9A15,
65% to CYP9A16, 62% to 9A14, 52% to 9A3
CYP9A23v1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_209 = CYP9A23v1 except for a 3 aa FFK insertion
HAH001047 100% to Contig_209, 1 aa diff to Contig_177
This seq is missing from Renes seq and it needs to be there.
CYP9A23v2.a Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
N-terminal
Contig_177 = CYP9A23v1 except for a 3 aa FFK insertion and 1 aa diff
HAH001985 100% to Contig_177
HAH006958 100% to Contig_177
HAH007484 has 2 aa diffs to Contig_177
CYP9A23v2.b Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
C-terminal
Contig_210 has 1 aa diff to 9A23v1
HAH005732 has 1 aa diff to Contig_210
.a and .b may belong to the same gene
CYP9A24 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
64% to CYP9A16
9A24 may be the ortholog of CYP9A16 of H. armigera
CYP9A25 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
75% to 9A23, 69% to 9A18
70% to 9A12v2, 67% to 9A27.
Genes 9A25 and 9A26 may be paralogs of CYP9A23 of H. armigera
CYP9A26 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
66% to 9A25, 65% to 9A23, 64% to 9A18
CYP9A27 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
69% to 9A18, 68% to 9A15,
9A27 may be an ortholog of CYP9A15 of H. armigera
CYP9A28 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
89% to adjacent 9A29, 78% to 9A30, 75% to 9A17v2
This one and The next 3 genes 9A28-9A31 look like
paralogs of CYP9A17 of H. armigera
CYP9A29 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
89% to adjacent 9A28, 77% to 9A30,
75% to 9A31, 71% to 9A17
CYP9A30 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
77% to 9A29, 80% to 9A28, 70% to 9A17
CYP9A31 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
78% to 9A28, 76% to 9A29, 73% to 9A30,
69% to CYP9A17
CYP9A32 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
69% to 9A1, 66% to 9A3,
may be an ortholog of CYP9A3 of H. armigera
CYP9A33 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_178 has 5 aa diffs to 9A23 plus two indels (one is FFK)
HARM_contig_2 100% to Contig_178, 98% to Contig_177
CYP9A33 Helicoverpa armigera (cotton bollworm)
No accession number
Ji Jichao
Submitted to nomenclature committee Aug. 27, 2012
99% to CYP9A33 Helicoverpa armigera 1 aa diff in 287 aa
complete seq.
CYP9A34 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_154 95% to HA-RN46_F13_CYP450
96% to CYP9A16, 3 aa diffs
CYP9A35 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HA-RN46_F13_CYP450 95% to Contig_154 9A34
98% to CYP9A16, 1 aa diff
CYP9A36 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_c7429
63% to CYP9A19 Bombyx mori
CYP9A37 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-2
60% to 9A19, 63% to CYP9A36
CYP9A38 Cnaphalocrocis medinalis (Lepidoptera: Pyralidae) rice leaffolder
No accession number
Zhifan Yang
submitted to nomenclature committee June 13, 2009
66% to CYP9A20 Bombyx mori
CYP9A39 Spodoptera litura (common cutworm)
No accession number
Jialiang Zhou
submitted to nomenclature committee July 28, 2009
75% to CYP9A8, 76% to CYP9A9, 76% to CYP9A10
CYP9A40 Spodoptera litura
No accesion number
Zihbin Xu, Sichun Zheng, Qili Feng
submitted to nomenclature committee April 17, 2011
87% to CYP9A32 Spodoptera frugiperda
CYP9A41 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
64% to CYP9A38 Cnaphalocrocis medinalis
CYP9A42 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
64% to CYP9A38 Cnaphalocrocis medinalis
CYP9A43 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
66% to CYP9A20 Bombyx mori
CYP9A44 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
64% to CYP9A13 Mamestra brassicae
CYP9A45 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
61% to CYP9A20 Bombyx mori
CYP9A46 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
77% to CYP9A45 Heliconius melpomene
CYP9A47v1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
89% to CYP9A14 Helicoverpa zea
CYP9A47v2 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
88% to CYP9A14 Helicoverpa zea
CYP9A48 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
83% to CYP9A14 Helicoverpa zea
CYP9A49v1 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
90% to CYP9A14 Helicoverpa zea
CYP9A49v2 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
93% to CYP9A14 Helicoverpa zea
CYP9A50 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
87% to CYP9A17v2 Helicoverpa armigera
CYP9A50 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
95% to CYP9A50 Heliothis subflexa
CYP9A51 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
89% to CYP9A25 Spodoptera frugiperda (possible ortholog)
CYP9A52 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
87% to CYP9A10 Spodoptera exigua
CYP9A53 ??
CYP9A54v1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP9A54v2 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP9A54v3 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP9A55 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP9A56 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP9A57 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP9A58 Spodoptera frugiperda (the fall armyworm)
CYP9A59 Spodoptera frugiperda (the fall armyworm)
CYP9A60 Spodoptera frugiperda (the fall armyworm)
CYP9A61 Cydia pomonella (codling moth)
No accession number
Yang Xueqing
Submitted to nomenclature committee March 28, 2013
59% to CYP9A20 Bombyx mori
9B Subfamily
Cyp9b1 Drosophila melanogaster
GenEMBL U34324(358bp)
Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B.,
ffrench-Constant, R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251, 290-297 (1996)
Cyp9b1 Drosophila melanogaster
GenEMBL AC006469, chromosome 2R, region 43A1-43A2
75% identical to AC006469 comp(54916-56640) 62% identical to CYP9B3
56640 VEICLVLATIGLLLFKWSTGTFKAFEGRNLYFEKPYPFLGNMAASALQKASFQKQISEFY 56461
56460 NRXX 56455
56384 SKLVGLFNLRTPMIQINDPQLIKKICVKDFDHFPNHQTLNIPNERLVNDMLNV 56226
56225 MRDQHWRNMRSVLTPVFTSAKMRNMFTLMNESFAQCLEHLKSSQPIAAGENAFELDMKVL 56046
56045 CNKLSNDVIATTAFGLKVNSFDDPENEFHTIGKTLAFSRGLPFLKFMMCLLAPKVF 55875
55806 KLTIFDSTNVEYFVRLVVDAMQYREKHNITRPDMIQLLMEAKKESKDNWTD 55654
55653 DEIVAQCFIFFFAAFENNSNLICTTAYELLRNLDIQERLYEEVKETQEALKGAPLTYDAA 55474
55473 QEMTYMDMVISESLRKWTLSAAADRLCAKDYTLTDDEGTKLFEFKAGDNINIPICGLHWD 55294
55293 ERFFPQPQRFDPERFSERRKKDLIPYTYLPFGVGPRSCI 55114
55113 GNRYAVMQAKGMLYNLMLNYKIEASPRTTRDMWESARGFNIIPTTGFWM 54934
54933 QLVSRK 54916
Cyp9b1 Drosophila melanogaster
GenEMBL AC019916 10502-12238
Cyp9b2 Drosophila melanogaster
GenEMBL U34325(358bp)
Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B.,
ffrench-Constant, R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251, 290-297 (1996)
Cyp9b2 Drosophila melanogaster
GenEMBL AC006469, chromosome 2R, region 43A1-43A2
66% identical to CYP9B3 44% to 9C1 over I-helix to heme
Cyp9b2 Drosophila melanogaster
GenEMBL AC019916 8190-9903
MALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEKPYPFVGNMAAAALQKSSFQRQLT
EFYERTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFITSNDRLFNDMLS
VMRDQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGFEVDMKV
MCNKLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLL
KLTIFDSAKVDYFARLVVEAMQYREKHNITRPDMIQLLMEAKNESEDKWTDDEIVAQCFI
FFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMV
ISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRK
FDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIK
DLWGSASGFNFTPRSGFWMHLVPRK
Cyp9b2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP9B3 Drosophila mettleri
GenEMBL AF083945
Danielson,P.B., Reeves,S.A. and Fogleman,J.C.
Isolation of a novel cytochrome P450 (CYP9B3) from Drosophila mettleri.
Unpublished
DU544mt
9C Subfamily
Cyp9c1 Drosophila melanogaster
GenEMBL U34326(358bp)
Dunkov, B.C., Rodriguez-Arnaiz, R., Pittendrigh, B.,
ffrench-Constant, R.H. and Feyereisen,R.
Cytochrome P450 gene clusters in Drosophila melanogaster.
Mol. Gen. Genetics 251, 290-297 (1996)
Cyp9c1 Drosophila melanogaster
GenEMBL AC019937 comp(1757-3443)
Cyp9c1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP9D1 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
submitted to nomenclature committee 8/14/98
new1
CYP9D1 Tribolium castaneum (red flour beetle)
GenEMBL AAX62142, NP_001034541, NM_001039452, AY920544
Some gene models are short, corrected below
lower case regions
mltlilgvilgaiiyyklrkpahfwakktsptchhgpllgnMWPFVV
QKKHITEIIADIYRQFPTDRYVGYYHFMTPTLLLRDVELIKQIGVKE
FDSFHDHVSVSNTNTEPLLSEALTNLPGEKWKEMRATLSPAFTSSKIKNM
YSLISECAENFVDFFQGREQDVEIKEVFSRFSNDVIATAAFGI
RVNSVQEPNNEFYAMGRSLTTFSAFQILKIFLAHLVPKIAEFFEYRVL
PRKVTDFFEGLILDNMQKREAEKIVRPDLIHLLMEARKGKLKHDNSNEG
GEGFATVEESEIGKNTKQVELTDEKIVAQALLFFFAGFETVSTGVSFMA
YELATNPHVQKKLQKEIDLTLQENHGKISYNVLQSMKYLDQVVCESLRLW
PPAPQTDRLCNKNFVIEASKPHERTFTVEKDTMVMISMFAIHRDPQYFP
DPEKFDPERFSDENKAKIVPGTYMPFGVGPRNCIgsrfalleiktlfc
hllAKFDIVPNGKTVIPIKISPSTANMVPQEGIHLTFKPRL*
CYP9D2 Tribolium castaneum (red flour beetle)
no accession number
Jeff Stuart
submitted to nomenclature committee 8/14/98
new2 9 diff with genomic seq below (98%)
CYP9D2 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000243.1
MLTTILLTLLSALIYFKLIKPASFWETRNVPHVTSWPLVGSMFPVLTQKKHFVEISQNIYTQFPNAK (2)
CVGYVLFTKPTLLIRDLDLLKQIGVK
8454 EFDSFHDHLPFVTEATEPLLSKSLLNLLGDEWRKMRATLSPAFTSSKMKHMYQLICECAE 8633
8634 RFTQHFGNRTVDVEIKDVFSRFSNDVIASAAFGIQVDSLKEPGNEFYSMGKAVTSILNGF 8813
8814 QMVKVFLAL (2) 8840
8887 LFHAIFQLIQFRAIPPKVTSFFYDIIIDNIKKRKNEGIVRPDMVHLLMEAQSGKLKHDNN 9066
9067 TEQVDGFATVEESEIGKNSNKIQLTDELIVAQALIFLLAGFDSVSTGLSFIAYELATNPD 9246
9247 VQKKLQEEIDSVLEKNQGKVMYNEIQSMKYLDQVLC (1) 9354
9922 ETLRLWPPAPQTDRYCNKDFPIDANFTIEKGVMIEIPIFAIHRDPQYFADPDKFDPGRFS 10101
10102 DENKSKIVPGTYIPFGVGPRNCI (1) 10170
10212 GSRFALLEIKILFWHLLSKFDILPNEKTVVPFKLCKRSSSLVPNEGIHLRFRPRK* 10379
CYP9D3 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000243.1
MLTIILSVVLGALIYYKLIKPASFWEERNITHASAWPLIGSMWESVIQKKNFNEISADIYKKYPNDR (2)
YVGYMQFSNPALLIRDLNLIKQIGVKA
6156 FDHFHDHLAFVGVKAEPLFSKSLAILQGEEWKQMRATLSPVFTSSKMKNMYHLIYECAEN 6335
6336 FAKHFQGRKEDVEVKDIFSKFTNDVIATAAFGIQINSLEEPNNEFYLMGKLLTTFKGWQ 6512
6513 LIN (2)
NNTILYRLIFEILFQLTKLNIFNQKVIKYFYDIIIDNIHKREK 6692
6693 EGIIRPDLIHLLMEARKGKLKHDNSNEGGDGFATVEESDIGKNSKQLELTEDLMVAQALI 6872
6873 FFFAGFETISTSFSFTAYELATNPDVQKKLQKEIDSAFQENHGKISYNVLQSMKYLDQVV 7052
7053 S(1)ESLRLWPPAPQTDRFCNTDFVLEPTKPDERRFTIEKGVTTIIPI 7232
7233 YGIHRDPQYFPNPDKFDPERFSDENKAKIVPGTYMPFGVGPRNCI (1)
7413 GSRLALLELKTLFFHLLSKCDIVTNSKTVIPLKISPNNGNITPKEGIHLSFKPRKINGKM* 7595
CYP9D4 Tribolium castaneum (red flour beetle)
GenEMBL XP_967481
78% to 9D7, 67% to 9D1
CYP9D5 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000243.1
87% to 9D3
1081 MLTIILSVVLGALIYYKLIKPASFWDERNITHASAWPLIGSMWESVIQKKNFNEISSDFY 1260
1261 KKYPNDR (2?)
1333 YVGYMQFSNPVLLIRDLDLIKQIGVKVFDNFHDHLAITGIKTDPLFSKSLIVLRGEEWK 1509
1510 QMRATLSPAFTSSKMKNMYHLIYECAENFAKHFQDEKKNVEVKDIFSKFTNDVIATVAFG 1689
1690 IQINSLKEPNNEFYSMGKLLTTFKGFELMKFFFALALPQIFE (0) 1815
1868 LTKLSLFNQKVTNFFRNIIIDNMHKREKDGIVRPDLIHLLMEARKGKLKHDNSN-EGG 2038
2039 DGFATVEESEIGKNSKKMELTDDLMVAQALLFFFAGFETISTGFSFMAYELATNPDVQKK 2218
2219 LQKEIDLTLQENHGKISYNVLQSMKYLDQVV 2311
2376 ESLRLWPPAPQTDRFCNTDFVLEPTKPHERRFTIERGVTIIIPIYGIHRDPEYFPNPDKF 2555
2556 DPERFSDENKAKIVPGTYMPFGVGPRNCI
GSRLALLELKTLFFH 2735
2736 LLSKCDIVTNSKTVIPLKISPNNGNITPKEGIHLTFKPRNVA 2861
CYP9D6 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000243.1 runs off the end
93% to 9D4
2 TDRFCNTHFVLEPTKPHERRFTIEKGVTVVFPIYGIHRDPQYFPNPDKFDPERFSDENKA 181
182 KIVPGTYMPFGVGPRNCI (1) 235
283 GSRLALLELKTLVFHLLSKCDIVTNSKTVIPLKISPNNANITPKEGIHLTFKPRNVA 453
CYP9D7 Tribolium castaneum (red flour beetle)
GenEMBL XP_973677
Gene model fused to another seq
this seq only seen in tribolium, delete the fusion part
78% to 9D4
MLTIILSVIFCALIYYKL
MKPANFWKKRNITHVPSWPLVGNMLDSIIQKKHILEISTDIYKKYPDDRYVGYMQFTNPTLLIRDIDLIK
QIGVKIFDSFHDHVTAAGIETEPLLNQSLISLHGEDWKRMRATLSPAFTSSKMKNMYHLIYECSENFAQH
FQDGKQNVEVKDIFSKFTNDVIATAAFGIQVNSLKEPDNEFYSMGKALTTFQGFQLIKFFFVQLVPKIAE
ILKVRFLNPKVANFFTSIIINNMQKRERDGIIRPDLIHLLMEARKGKLKYDKGNEFGDGFATVEESEIGK
NTKQVELTDDLIVAQALLFFFAGFDTVSTGASFLAHELATNPDVQKKLQEEIDMVLEENHGKISYTRIQS
MKYLDQVISESLRLWPPAPQTDRFCNTDFVLEPTKPHERRFTIEKGVTTIIPIYGIHRDPQYFPNPDKFD
PERFSDENKAKIVPGTYMPFGVGPRNCIGSRFALLELKTLFFHLLSKCDVIPNEKTVIPLKISPNNASIT
PKEGIHLTFRPRNFVQFKKSF
CYP9D8 Tribolium castaneum (red flour beetle)
GenEMBL XP_973646, AAJJ01000243.1
AAJJ01000243.1 around 88kb
89% to 9D4, runs off the end of the contig
MLTIILSVVLGALIYYKLIKPASFWEERNITHVSAWPLVGN
87975MWSTFIQKKNFNEISNDIYKKYPNDRYVGYMQFTDPVLLIRDLDLIKQIGVKVFDNFRDHHAVAGFKTEP
LFNKSLAFLEGEEWKQMRATLSPAFTSSKMKNMYHLIYECAENFAKHFQGKKQDVEVKDVFSRFTNDIIA
TVAFGIQINSLEERNNEFYLSGKSVTTFSGKQLLKFFAAQVIPQVFEFFKVGVFDQKIVKYFNDIIIDNM
HKREKEGIIRPDLIHLLMEARKGKLKHDNSNEGGDGFATVEESDIGKNSKKMELTDELMVAQALLFFFAG
FETISTGASFLAHELATNPDVQRKLQEEIDSVLEENQEKISYTTIQSMKYLDQVIS
CYP9E1 Diploptera punctata (cockroach)
no accession number
Rene Feyereisen
submitted to Nomenclature Committee
77% identical to CYP9E2
CYP9E2 Blatella germanica (German cockroach)
no accession number
Jeff Scott
submitted to nomenclature committee 3/8/99
77% identical to CYP9E1
CYP9F1 Drosophila mettleri
GenEMBL AF083947
Danielson,P.B., Al-Zahrani,A. and Fogleman,J.C.
Isolation of a novel CYP9 cytochrome P450 from Drosophila mettleri
Unpublished
46% identical to CYP9B3 46% to CYP9B4 47% to CYP9B5 38% to CYP9A1
44% to 9C1 partial seq.
Cyp9f2 Drosophila melanogaster
GenEMBL AC017132 AC017240 AC009741 AC017170 AC007594
ESTs AA735946 AI113499 AI259899
78% IDENTICAL TO Cyp9f1
Cyp9f2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp9f3p Drosophila melanogaster
GenEMBL AC017132 AC017240 AC009741 AC017170 AC007594
PLUS ESTs
CYP9F4 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP9F1
65% to 9F2 (364 aa)
CYP9F4 Lucilia sericata (sheep blowfly)
CYP9F5 Lucilia sericata (sheep blowfly)
CYP9F6 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
57% to CYP9F1 D. mettleri
clone name 639
CYP9G1 Bombyx mori (silkworm)
no accession number
Manabu Kamimura
submitted to nomenclature committee 3/22/99
42% identical to CYP9E2
CYP9G2 Plutella xylostella (L.) (diamondback moth)
GenEMBL AB096739
Ben-Chang,S. and Chuan-Ling,Q.
Molecular Cloning and Complete cDNA Sequence of Cytochrome P450 in
Plutella xylostella (L.)
Published Only in Database (2002)
49% to 9G1
CYP9G2 Plutella xylostella
Gene number CCG014982.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
missing N-term
CYP9G3 Bombyx mori (silkworm)
ESTs CK508550 BP125176 AU000984 CK510649 BP127468
BAAB01164136.1 BAAB01189844.1 BAAB01100167.1 BAAB01034600.1
59% to CYP9G1
See silkworm page for sequence
CYP9G3-de9b10b Bombyx mori (silkworm)
BAAB01034600.1 pseudogene detritus exons downstream of CYP9G3
2492 DFLFNVANSIHIDPIYHTEPDTFNPARFLVENEYQMREFTFMPFSIGPRNFF
4065 GKGFALL*IKLILYYLVLNFKVMKFMKTQNPIKLIQHEFNLEV 4193
CYP9G4 Plutella xylostella (L.) (diamondback moth)
No accession number
Anita Bautista
Submitted to nomenclature committee Dec. 10, 2005
Clone name Sequence 2. 6XYR 17 fragment (C-terminal)
63% to CYP9G2 61% to 9G1, 58% to 9G3
CYP9G4 Plutella xylostella (L.) (diamondback moth)
FJ023535, EST BP937771 (partial seq)
Ji Hyeong Baek
Submitted to nomenclature committee Aug. 14, 2008
99% to 9G4 fragment of Bautista, (1 aa diff in 124 aa)
70% to 9G2, 55% to 9G3, 54% to 9G5, 50% to 9G1
note: 9G1 and 9G5 have 30 missing amino acids in the middle region
complete sequence
CYP9G4 Plutella xylostella
Gene number CCG014981.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
CYP9G5 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_167 78% TO CYP9G3, 51% to CYP9G1
HARM_contig_3 has 3 aa diffs to Contig_167
CYP9G6 Danaus plexippus (monarch butterfly)
EY269870.1 EY257342.1 EY274447.1 ESTs
86% to 9G7, 57% to 9G3
MIIEIVVFILTSLIIYFIYIHKSIHKYFDDRGIKYLPGVPIFGNNFRSWFLKRHLLDDLD
SVYKAFPEERYVGYIEGTTKIIIIRDPEITRNITVKDFQHFTDHKTFFSEETEPLFGGSL
FSMKGERWHSMRTTLSPAFTSSKMRLMMPFMSEISSNIVEYLKGHV
NEYVDVQDLMRRYTNDVIASAAFGLQVNSVKDRDNEFFNIGRDLFSFTFFQRF
YMIFVALFPNFTKNLGITIFPKKVMHFFKGLVVNTMQHREKNNIHRPDMIQLLMEASKGT
LKDESDKSQTNEASKQKPEKEWTLEEIASQVFIFFAAGYETSASTLVMCVHELALNPDVQ
EKLYQEIKEYKDKHGEITFEHIHNLKYLDCVLNETSRKWSA
ALIMDRACTIPYELPPPREGLKPVQLQPGDVVYNMVNCIHMDPIYHP
(missing about 89 aa)
CYP9G7 Danaus plexippus (monarch butterfly)
EY256661.1 EY258344.1 ESTs
86% to 9G6, 57% to 9G3
XXXXXXVFLLTSLIVYFIYIHKSIHKYFDDRGIKYLPGVPFFGNNLRSSFLKVHVLEDLEAV
YKAFPEERYVGYIEGTTKIIIIRDPEVMRNITVKDFQHFTDHKTFVSEDSEPLFGRSLFF
MKGERWHSMRTTLSPAFTSSKMKLMMPFMSEISTNIVEYLKGHVNEDVDVQ
DLMRRYTNDVIVSAAFGLPVNSVKDRDNE
FFTIGRDLFSFTFFQKIYSILVAFPNFMKKLGITVFPKKVINFFKGILVNTMQNREKNNI
HRPDMIQLLMEASKGILKDESDTNGNKSQNNEASKQKPIKEWSVEELSSQVFIFFAAGYE
SSASTLVMCVHELALNPDVQEKLYQEIKEFXDKHGEITFEHIHNLKYLDCVLSETSRKMVN
(missing about 126 aa)
CYP9G8 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP9G9 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
65% to CYP9G3 Bombyx mori
CYP9G10 Plutella xylostella
Gene number CCG014978.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
73% to CYP9G2 Plutella xylostella AB096739
CYP9G11v1 Plutella xylostella
Gene number CCG003485.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
98% to CCG013884.1 (7 aa diffs)
61% to CYP9G2 Plutella xylostella AB096739
CYP9G11v2 Plutella xylostella
Gene number CCG013884.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
missing 73 aa at N-term
98% to CCG003485.1
CYP9G12 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
Cyp9h1 Drosophila melanogaster
GenEMBL AC017648 8657-10342 also AC005450
Cyp9h1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP9J1 Aedes aegypti strain RED yellow fever mosquito
GenEMBL AF390099
Isabelle Morlais
Low 40% range to other CYP9 members
40% to 9A1, 40% to 9F1, 41% to 9D1
CYP9J1/9J2v2 Aedes aegypti (yellow fever mosquito)
probable allele of 9J2 gene
CYP9J2 Aedes aegypti (yellow fever mosquito)
GenEMBL AF329892
Isabelle Morlais
96% to 9J1
Low 40% range to other CYP9 members
40% to 9A1, 40% to 9F1, 41% to 9D1
CYP9J2 Aedes aegypti (yellow fever mosquito)
CYP9J3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPr3l1
This gene cluster includes CYP9L1, L2 and L3
CYP9J4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPr3l2
This gene cluster includes CYP9L1, L2 and L3
CYP9J5 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPr3l6
This gene cluster includes CYP9L1, L2 and L3
CYP9J6 Aedes aegypti (yellow fever mosquito)
CYP9J6 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I2.1
CYP9J7 Aedes aegypti (yellow fever mosquito)
CYP9J7 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1.5
CYP9J8 Aedes aegypti (yellow fever mosquito)
CYP9J8 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T2.2
CYP9J9 Aedes aegypti (yellow fever mosquito)
CYP9J9v1 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T2.3
CYP9J9v2 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T2.1
CYP9J9v3 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T1.3
CYP9J10 Aedes aegypti (yellow fever mosquito)
CYP9J10-de2b Aedes aegypti (yellow fever mosquito)
CYP9J10-de1c Aedes aegypti (yellow fever mosquito)
CYP9J10v1 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6T2.5
CYP9J10v2 Aedes aegypti (yellow fever mosquito)
No accession number
David, J-P and Dauphin-Villemant, C.
I-helix to heme fragment
Clone name 6I1.5
CYP9J11 Anopheles funestus
No accession number
Dolphine Achieng Amenya, Lizette Koekemoer
submitted to nomenclature committee 7/6/04
Contig 1
80% to CYP9J5
probable ortholog of CYP9J5
CYP9J12 Anopheles funestus
No accession number
Dolphine Achieng Amenya, Lizette Koekemoer
submitted to nomenclature committee 7/6/04
Contig 3
84% to CYP9J3
probable ortholog of CYP9J3
CYP9J13 Anopheles funestus
No accession number
Dolphine Achieng Amenya, Lizette Koekemoer
submitted to nomenclature committee 7/6/04
Contig 5
84% to CYP9J4
probable ortholog of CYP9J4
CYP9J14 Anopheles funestus
No accession number
Dolphine Achieng Amenya, Lizette Koekemoer
submitted to nomenclature committee 7/6/04
Contig 7
55% to CYP9J5
not an ortholog of other Anopheles CYP9Js
CYP9J15 Aedes aegypti (yellow fever mosquito)
CYP9J16 Aedes aegypti (yellow fever mosquito)
CYP9J17 Aedes aegypti (yellow fever mosquito)
CYP9J18v1 Aedes aegypti (yellow fever mosquito)
CYP9J18v2 Aedes aegypti (yellow fever mosquito)
CYP9J19 Aedes aegypti (yellow fever mosquito)
CYP9J20v1 Aedes aegypti (yellow fever mosquito)
CYP9J20v2 Aedes aegypti (yellow fever mosquito)
CYP9J20 Aedes aegypti (yellow fever mosquito)
CYP9J21 Aedes aegypti (yellow fever mosquito)
CYP9J22 Aedes aegypti (yellow fever mosquito)
CYP9J23 Aedes aegypti (yellow fever mosquito)
CYP9J24 Aedes aegypti (yellow fever mosquito)
CYP9J25P Aedes aegypti (yellow fever mosquito)
CYP9J26 Aedes aegypti (yellow fever mosquito)
CYP9J27 Aedes aegypti (yellow fever mosquito)
CYP9J28 Aedes aegypti (yellow fever mosquito)
CYP9J29 Aedes aegypti (yellow fever mosquito)
CYP9J30 Aedes aegypti (yellow fever mosquito)
CYP9J31 Aedes aegypti (yellow fever mosquito)
CYP9J32 Aedes aegypti (yellow fever mosquito)
CYP9J33 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 17
62% to 9J23 Aedes, 61% to 9J5 Anoph.
CYP9J33 Culex pipiens
CYP9J34 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 18
59% to 9J5 Anoph., 67% to 9J28 Aedes
CYP9J34 Culex pipiens
CYP9J35 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 19
76% to 9J9v1 Aedes, 58% to 9J4 Anoph.
CYP9J35 Culex pipiens
CYP9J36 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 20
57% to 9J4 Anoph., 76% to 9J10 Aedes
CYP9J36 Culex pipiens
CYP9J37 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 21
63% to 9J16 Aedes, 55% to 9J4
CYP9J37 Culex pipiens
CYP9J38 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 22
55% to 9J4 Anoph, 69% to 9J8 Aedes
CYP9J38 Culex pipiens
CYP9J39 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 23
63% to 9J26 Aedes, 57% to 9J5 Anoph.
CYP9J39 Culex pipiens
CYP9J40 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 24
60% to 9J5 Anoph., 66% to 9J22 Aedes
CYP9J40 Culex pipiens
CYP9J41 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 25
58% to 9J7 Aedes, 56% to 9J5 Anoph.
CYP9J41 Culex pipiens
CYP9J42 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 30
53% to 9J5 Anoph., 67% to 9J6 Aedes
CYP9J42 Culex pipiens
CYP9J43 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 34
55% to 9J5 Anoph., 68% to 9J6 Aedes
CYP9J43 Culex pipiens
CYP9J44 Culex pipiens
CYP9J45 Culex pipiens
CYP9J46 Culex pipiens
CYP9J47 Culex pipiens
CYP9J48 Culex pipiens
CYP9K1 Anopheles gambiae (malaria mosquito)
no accession number
Hilary Ranson
submitted to nomenclature committee 1/31/02
clone name 105
41% identical to CYP9E2
CYP9K1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x2
CYP9K1 Anopheles funestus
No accession number
Ashley Vaughan, Dolphine Achieng Amenya, Hilary Ranson,
Lizette Koekemoer
submitted to nomenclature committee 3/17 /05
76% to CYP9K1
ortholog of Anopheles gambiae CYP9K1
CYP9L1 Anopheles gambiae (malaria mosquito)
no accession number
Dimitra Nikou
submitted to nomenclature committee 2/25/02
clone name 18B07
41% to 9K1
CYP9L1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPr3l5
CYP9L2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPr3l4
CYP9L3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPr3l3
CYP9L4 Anopheles funestus
No accession number
Ashley Vaughan, Dolphine Achieng Amenya, Hilary Ranson,
Lizette Koekemoer
submitted to nomenclature committee 3/17/05
76% to CYP9L2 and 9L3
cannot assign ortholog from Anopheles CYP9Ls without map info
CYP9M1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPp3r1
CYP9M2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPp3r4
CYP9M3 Anopheles funestus
No accession number
Dolphine Achieng Amenya, Lizette Koekemoer
submitted to nomenclature committee 7/6/04
Contig 2
84% to CYP9M2
probable ortholog of CYP9M2
CYP9M4 Aedes aegypti (yellow fever mosquito)
CYP9M5 Aedes aegypti (yellow fever mosquito)
CYP9M6 Aedes aegypti (yellow fever mosquito)
CYP9M7 Aedes aegypti (yellow fever mosquito)
CYP9M8 Aedes aegypti (yellow fever mosquito)
CYP9M9 Aedes aegypti (yellow fever mosquito)
CYP9M10 Culex quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
Submitted to nomenclature committee July 10, 2007
68% to CYP9M6
CYP9M10 Culex pipiens
CYP9M10-de1b Culex pipiens
CYP9M11P Culex pipiens
CYP9M12 Culex pipiens
CYP9M13P Culex pipiens
CYP9M14 Culex pipiens
CYP9N1 Mayetiola destructor (Hessian fly)
No accession number
Omprakash Mittapalli, Richard Shukle
Submitted to nomenclature committee Nov. 30, 2004
clone name HfP450-3 and HfP450-4
Two clones have the same amino acid sequence
Missing the C-terminal
40% to CYP9J4 in the first 323 amino acids
CYP9P1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7a
40% to Cyp9f2 Drosophila melanogaster. 50% to 9J8 partial seq.
63% to CYP9P2
formerly CYP335A1
CYP9P2 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7b
40% to CYP9K1 Drosophila melanogaster. 54% to 9J7 partial seq.
63% to CYP9P1
formerly CYP335A2
CYP9P3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9P4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9P5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9P6 Linepithema humile (argentine ant)
No accession number
CYP9P7 Linepithema humile (argentine ant)
No accession number
CYP9P8 Linepithema humile (argentine ant)
No accession number
CYP9P9 Linepithema humile (argentine ant)
No accession number
CYP9P10 Linepithema humile (argentine ant)
No accession number
CYP9P11 Linepithema humile (argentine ant)
No accession number
CYP9P12 Linepithema humile (argentine ant)
No accession number
CYP9P13 Linepithema humile (argentine ant)
No accession number
CYP9P14 Linepithema humile (argentine ant)
No accession number
CYP9P15 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
68% to CYP9P11 Linepithema humile
CYP9P16 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
66% to CYP9P9 Linepithema humile
CYP9P17 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
68% to CYP9P11 Linepithema humile
CYP9P18 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
66% to CYP9P9 Linepithema humile
CYP9P19 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
67% to CYP9P12 Linepithema humile
CYP9P20P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
59% to CYP9P9 Linepithema humile
CYP9Q1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7c
39% to CYP9E 42% to 335A1
57% to CYP9Q2
formerly CYP335B1
CYP9Q2 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7d
57% to CYP9Q1
formerly CYP335B2
CYP9Q3 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7e
58% to CYP9Q2
formerly CYP335B3
CYP9R1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7f
44% to CYP9Q2
formerly CYP335C1
CYP9R2P Linepithema humile (argentine ant)
No accession number
CYP9R3 Linepithema humile (argentine ant)
No accession number
CYP9R4 Linepithema humile (argentine ant)
No accession number
CYP9R5 Linepithema humile (argentine ant)
No accession number
CYP9R6 Linepithema humile (argentine ant)
No accession number
CYP9R7 Linepithema humile (argentine ant)
No accession number
CYP9R8 Linepithema humile (argentine ant)
No accession number
CYP9R9 Linepithema humile (argentine ant)
No accession number
CYP9R10 Linepithema humile (argentine ant)
No accession number
CYP9R11 Linepithema humile (argentine ant)
No accession number
CYP9R12 Linepithema humile (argentine ant)
No accession number
CYP9R13 Linepithema humile (argentine ant)
No accession number
CYP9R14 Linepithema humile (argentine ant)
No accession number
CYP9R15 Linepithema humile (argentine ant)
No accession number
CYP9R16 Linepithema humile (argentine ant)
No accession number
CYP9R17 Linepithema humile (argentine ant)
No accession number
CYP9R18 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
75% to CYP9R6 Linepithema humile
CYP9R19 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP9R9 Linepithema humile
CYP9R20 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
73% to CYP9R6 Linepithema humile
CYP9R21 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
73% to CYP9R14 Linepithema humile
CYP9R22P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
76% to CYP9R6 Linepithema humile
CYP9R23P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
64% to CYP9R9 Linepithema humile
CYP9R24P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
50% to CYP9R9 Linepithema humile
CYP9R25P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
43% to CYP9R9 Linepithema humile
CYP9R26 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
73% to CYP9R7 Linepithema humile
CYP9R27 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
76% to CYP9R9 Linepithema humile
CYP9R28P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
58% to CYP9R9 Linepithema humile
CYP9R29 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP9R6 Linepithema humile
CYP9R30 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
72% to CYP9R10 Linepithema humile
CYP9R31 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
79% to CYP9R13 Linepithema humile
CYP9R32 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
73% to CYP9R10 Linepithema humile
CYP9R33P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
50% to CYP9R8 Linepithema humile
CYP9R34P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
48% to CYP9R9 Linepithema humile
CYP9S1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7g
49% to CYP9R1
renamed CYP9
formerly CYP335D1
CYP9T1 Ips paraconfusus (California fivespined ips, bark beetle)
No accession number
Dezene Huber
Submitted to nomenclature committee May 19, 2005
38% to 9D1
CYP9T1 Ips confusus (Pinyon Ips, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on August 28, 2006
Full length sequence
98% to 9T1, only 8 aa diffs
clone name #1
CYP9T2 Ips pini (pine engraver, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
full length
94% to CYP9T1
Clone name EST 2G06
CYP9T3 Ips pini (pine engraver, bark beetle)
No accession number
Claus Tittiger
Submitted to nomenclature committee on Oct. 20, 2010
93% to CYP9T2, 94% to CYP9T1 Ips paraconfusus
CYP9U1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP9F2
50% to 9F2 52% to 9F4 (352 aa)
CYP9V1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee June 29, 2005
44% to 9D1 44% to 9T1
CYP9V1v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
98% to CYP9V1v1 (8 aa diffs)
CYP9V2v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V12ic4
68 amino acids from heme to end
94% to 9V1, 3 aa diffs to CYP9V2v2
CYP9V2v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V117ic4
68 amino acids from heme to end
94% to 9V1, 3 aa diffs to CYP9V2v1
CYP9W1 Tribolium castaneum (red flour beetle)
GenEMBL XP_972391
51% to CYP9D7
MWYVYLSIFCGFLALFIYYKIIKPANFWKKRNVPHESTFALLQRKHPATILTQLYQKHKDQRYVGYLQLN
HPFLMIRDLELIKQLTVKDFESFHDHYPFSYAKNDPILGKSLLMLNGQDWKQMRATLSPAYTTNKLKNMH
QLMTECAQNFVGHFKGREKVAVDMKDIFTRFTTDVIASTAFGIKTDSLNQPNNRFFLMAKSLSKFGFIQV
VKILISSFAKVGIFPSSVVNYFGTIIKSNIRERKQSCIVRPDMIHLMLEANKGQANQLTDDDIVAQAMTF
FFAGFETVATACSFMAYELAIHPEIQQKLQAEIDSVGGVTYESLLSMKFLDQVVSESLRLWPPGFQIERM
CTKSYKIEPKNHNEKGIVLEEGVSLIIPVIALHHDPDLFPEPDRFDPERFSEANRSQIVPGSYLPFGVGP
RNCIASRFALLEIKTLFFHMLSKFDIVPIDTTQIPLKLSTKKMHLEPEKGFRLGIRPRKV
CYP9X1 Tribolium castaneum
GenEMBL XP_972443
52% to 9D7
MLLLLVLGVLLSCIWTYYKIIKPVKYWQERDVTHARAWPIVGSLNQVTLKKKHIADAIDEIYQHFPNQRC
VGYMHFTTPFLMVRDLDLIKKITVKDFDHFQDRLASKTIKTDPLLSKSLLSLGGENWKRMRATISPVFTS
SKMKFLFGLMDECAKNFTGHFTQNETKLEMKDVFSKFANDVIASTAFGIRIDSLQDPTNEFYKLGSSFIN
FGWWDIAKVLVMQLSPGLANLLQLRVFSEETSTFFRSLVKDNIRKRQSEGIIRPDLIQLLMQAQNGDEIQ
HSSEKIALTEDHFVSQALTFFIAGFETVSTAACFMAQELALNPHIQKRLQVEIDSVLENHKGDISYETLQ
SMKYLDQVVEETLRLWPPATQTDRLCVKSYVIEPVNPKEKVVFVEKGVSVLVPVMSIQRDSSFWEKPNKF
DPERFSEENRAKIVPGTYLPFGTGPRNCIGSRFALLELKILFFHLLAKFILVPCDNTPIPLKLDPKKLTM
SPENGFQLSLRRRLLSP
CYP9Y1 Tribolium castaneum
GenEMBL XP_972348
49% to 9AB1
gene model too long
delete the fusion part at N-term
MLAVLLLVFVFLAVIYFKLVVPFFYWQKRDIFYVKPWT
RFRKVFLGKESFAEAVRAAYDEHPDKRYYGSYQFLQPSLFVRDLDLIKAITVKDFEHFTDHSAFTSEKTD
PILGLNLFSLKGQKWREMRSTLSPAFTGSKMRAMFTLIAQTAESFTQYLLGLGQGVVEVEMKDTCTKFTN
DVIANCAFGIECNSLLNPENEFYKMGTMVSKPSPWRLFKTLPPTISDFFLRIIKDAIIVREQQGIVRPDM
IHLLLEARKGRLKHDKIESNEPGFATVQESTIGQNEKSLQITDELITAQALVFFIAGFTTSSSLMSFLAY
ELVVNPEIQKKMQKEIDAFLDREFSYEQVLQMKYLDQVVSEALRKYPPGYVLNRICVKDYVIKPKQEGEK
VAVIEKGCLVAIPVIALHYSPEFFPDPEKFNPERFSDENKGKILPGSYIPFGLGPRNCIGSRFALLEIKV
LLVKLLAKFDLVPVDKTVIPLKFAKTLGLDAKGGIWVGLKKRT
CYP9Z1 Tribolium castaneum
GenEMBL XP_975381
66% to 9Z4, 56% to 9Z5
MILLCLIAVIVILSYRFLYRPHKYWLERGVIQGNPKPLLGHFMGTTFHKQSFADCIQMVYNMAPNSRYCG
MYQFTMPTLVVRDPDLIKQITVKDFDYFLNHRTFIPEECDALWGKNLFALTNQKWRDMRSTLSPAFTGSK
MKFMFPLISETAEYFIRHFLSKQEDVVTVEMKDAFTRFTNDVIANTAFGVSCDSLKERENEFYLMGKEAT
DLKGFWKNIKLLLFFLIPQVFKLCKVRFFSKSVANFFTNLIKGNITKREEFGIVRPDMIYLLMEARKNVS
NEPISDEDITAQALIFFFAGFDTVSSAMCFMSYELATNPEIQEKLLQEIDSVEGKPTYDTLMNLKYLDMV
VSETLRKWPISVATDRICNKPYTIEPKSPDKRPLLLEKNLAVWIPVYALHRDPNYFPDPNRFDPERFNEE
NKANIKPYTYLPFGLGPRNCIGSRFALLEMKILFFYILSHFEITPIPRTQIPLKINKTQFALTAEDGFWL
GLKRRQK
CYP9Z2 Tribolium castaneum
GenEMBL XP_975385
69% to 9Z4
MFWILIVIAAIIAISYHQLRRYHKYWSEKGVQQGDPLPLFGHCLGTTLQKQSLSEFIQMSYNVAPDARYC
GIYQFYSPILIVRDPELIKQITVKDFDHFVNRMAFIPEDCDPLWGKNLVALTDQRWRDMRSTLSPAFTSS
KMKYMFSLISESAEQFAQYFANQDQDLITIEMKDIFTRFTNDVIANTAFGVKIDSLEERNNEFYLMGIEA
TDFRGFWRNMKIVIYFIFPTLFKSLGWRFFSKNVADFFVKLVRDNIAKREKHGIVRPDLINLFLEARKNG
LKYEEQEHALDTGFATAEESEIGKNGMVRQTLTDVDIAAQALLFFFGGFDSVSSMMCFMSYELALNPDVQ
AKLLREVDETFESCDGKLTYEALIKMKYLDMVVSETLRLWPTNVSADRVCTKPYTIEPKNPNEKALHLEK
NTNVIVPIFGIHRDAKNFPEPNRFDPERFSDENKANIRPYTYLPFGAGPRNCIGSRFALLETKALFFHLL
SKFEITPVEQTQIPIQLNRKSFNMTAENGFWLGLKRRKNDN
CYP9Z3 Tribolium castaneum
GenEMBL XP_975390
61% to 9Z1
MIWFSTAVITIIALFYWLLIRPFKHWIKKGVAQGNPVPVFGHLLGTILHKQSFSEMIQTVYNIAPDSRYC
GMYQFFQPMLVLRDPELIKQITVKDFDLFMNHKGFIPPDCEPLMGKVLILLTDQKWKDMRNTLSPAFTSS
KMKYMFGLISESAQRFTGHFSKKNDNVITIEMKDIFSRFTNDVIANTAFGVEIDSLEEPNNEFYLMGLEI
TNFQGVVTFLKFLTFVILPRVAKFLKLTFFSKKVGKFFTKVIKENIANREKHGIVRPDMVNLLLEARKNS
DTQKITDEDITSQAIIFFMGGFDPVSSLMSFMSYELAANPDVQTKLLREIDKTYERCDGKLTYEALVEMK
FMDMVVSETLRLWPANGMTDRVCNTSYIIEPKDSTEKPLRLEKGDVVMVPIFGIQRDPKYFPEPNRFDPE
RFNEENKIKIKPYTYLPFGTGPRNCLGTRLALLETKALFFHLLSTFEIIPVEKTEIPLRLTRKSFNMTAE
NGFWLGLKRRSDKL
CYP9Z4 Tribolium castaneum
GenEMBL XP_975395
69% to 9Z2, 68% to 9Z3
MLWILVSIAIIALSYLFLIRPFKYWTNLGVEQGNPVPVFGHSWGTIVHTQSFADLVQMVYNIAPGARYSG
MYQFFTPTLVLKDPDLIKQIAVKEFDSFLNHRSFIPEDVDPLWSKNLFSLTNQKWRDMRSTLSPAFTSSK
MKYMFVLISESAEQFIGHFLKQKEDVITIEMKDTFTRFTNDVIANTAFGVKIDSLEERNNEFYLMGKEAT
DFKGFWRNLKFLILLSCPTLFKYLGINFFPKAVSSFFRRLVKDNINNREKHGIVRPDMINLLLEARKNVE
ESDIGKNGAIKQKITDDDITAQALLFFFGGFDSVSSLMCFMSYELGINPDVQEKLHQEIDETLEACKGKL
TYEALMKMKYMDMVISETLRLWPTAVASDRLCNKPYTIEPKDPTEKPIHLEKNSVVWIPIFAIHRDPQYF
PEPNRFDPERFSDENKNNINPYAYMPFGVGPRNCIGSRFALLETKALFFHILSKFEIVPIEKTEIPLQLN
RKSFSMTAENGFWFGLKRRESNK
CYP9Z5 Tribolium castaneum
GenEMBL XP_975402
57% to 9Z4
MFWALILAAVLLVTYWLLSRPYKYWTERGVKQGKPVFIFGDYWGPMLRKQTNAEVVDMLYNQIDKEARYC
GIYQFLTPVLLIRDPELIKKITVKDFEHFVDHRIVIPEESDPLSGQKWRDMRSTLSPVFTSSKLKYMFSL
ISERGEQFAQSLLKENKDVITLDIKNSFTRYTNDVMASTMFGITCDSLQEPKNEFYSLAQKSQDFSGFWK
NVKLLGYFLFPEFCKSLEISFYSKEVNSFFEKLVTENIGSRQKHGIVRPDLIHLLMEAKNHAKKSTGYQE
SNKMKTEITDQDIATQALIFFFGGFDTVASLMSFMSYELATNPDCQEKLRQEVDEVMQNCNGKVTYEAIV
NMKYMDMVTSETLRKWPNAPAVDRVCTKPYTIEPARPDEKPIHLKENDTVLLPIYALHRDPKYFPNPDRF
EPERFSEENKANIEPYTYMPFGSGPRNCIGQRFALIETKLFFFYILANFELIPVERTQIPLKLTKNPFTM
TAEKGFWLGFKKR
CYP9Z6 Tribolium castaneum
GenEMBL XP_972794
63% to 9Z7
MFWILVGLALVALYWALSRPHSYWKRKGVVQGSPVFLLGDSWPMLFRKYSPPEMTELFYKASPNTRYFGI
YEFLTPGLLLRDPDLIKQITVKDFDHFVDRRPFVPEKADPLFGKSLFSLKGPKWRAMRSTLSPVFTSSKM
KYMFQLMSQTGERFINHFLNQKEEVVTVEMKEITTKFANDVIGNIVFGYECDSVKDPKNEFYVMGADLTN
FRSLRFLLVFSAKSIFQLFKIPLFPKKVSDFFVRVVNDNIESREKHGIVRPDMIHLLLKMKSNNLKHEEV
ETVPDAGFASVEESELGKNAKTVTKITNEDIAAQALLFFFAGFDSVSSLISYMAYELAVNPDVQTKLLQE
VDETRQKSDGKITYEALMSMKYMDMVVSEALRKWPNAIATERVCTKPYTIEPKLPDEKPLRLEIGDVVAI
PMYAIQRDPKYFPEPERFIPERFSDENKSKVQPYTFMSFGTGPRSCIGSRFALLETKLLFYYFLTNFEFV
PVEKTQIPIKFNRKALNMSPENGFWLGLKRRV
CYP9Z7 Tribolium castaneum
GenEMBL XP_972840
63% to 9Z6
MLLVLLAIATLIYFYWKIIYPHKYWTRKGVPQSKPVFLFGDIWPMIIRKYSAPELVDEFYKIDQNARYCG
VYQFLSPGLILRDPELIKEITVKDFDHFVDRRVFVKENVDPVFGRSLLSLDGEKWRNMRAAVSPVFTSSK
MKYMFPSISQCGEDFANYFLKQNKDLLELEMKESITKFTNDVIANTVFGFTCNSLENPNNEFYKMGDEVG
NMTSMRTRIVFLMNALAPKILSFFKIYLFSPRIYTFFRQVVNENISSREKHGVTRPDMIDLLVKAKNNSL
KNEEADDLPEAGFTTVKDTENGKKSRKYQITDEDIVAQALLFFFAGFDSVAGVISYMCYELAVAQDAQEK
LRQEVDETREKCGGKISYEELMKMKYMHMAVSETLRKWPTAIASDRVCVKPYTIQPKLPNEKPLHLKVGD
TVNIPIYAIQRDPQYFPEPDRFIPERFSEENKSKIVPYTYMSFGTGPRSCIGYRFALLEMKILMYHLISN
FEIVPVAKTQIPIRFNPKAVNMTAEKGFWVGLKRRVKV
CYP9Z8 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9E25017
63 amino acids from heme to end
65% to 9V1, 54% to 9E2, 78% to CYP9Z2 = XP_975385
CYP9Z9 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9E22146
62 amino acids from heme to end
66% to 9V1, 58% to 9R1, 77% to CYP9Z2, 93% to 9Z8 (4 aa diffs)
CYP9Z10 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9J12446
64 amino acids from heme to end
67% to 9V1, 61% to 9A19, 73% to CYP9Z2, 88% to 9Z9, 87% to 9Z8
CYP9Z11 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V2046
64 amino acids from heme to end
64% to 9V1, 60% to 9R1, 85% to 9Z8
74% to 9Z2 = XP_975385
CYP9Z12v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V1433
66 amino acids from heme to end
64% to 9A19, 62% to 9V1, 96% to CYP9Z12v2 (1 aa diff)
69% to CYP9Z2 = XP_975385
CYP9Z12v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V1103RRB3
66 amino acids from heme to end
62% to 9V1, 62% to 9A19, 77% to 9Z14v1
67% to CYP9Z2 = XP_975385
CYP9Z13 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V44c61
66 amino acids from heme to end
62% to 9V1, 61% to 9A19, 59% to 9E2,
69% to CYP9Z3 = XP_975390, 78% to 9Z14v1
CYP9Z14v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V1like273r42
136 amino acids from EXXR to end
61% to 9V1, 57% to 9D1, 57% to 9E2,
69% to 9Z2 = XP_975385
98% to CYP9Z14v2 (2 aa diffs), 97% to CYP9Z14v3 (3 aa diffs)
CYP9Z14v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V1043
136 amino acids from EXXR to end
60% to 9V1, 53% to 9A19, 68% to 9Z2 = XP_975385
CYP9Z14v3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P9V1153
136 amino acids from EXXR to end
61% to 9V1, 58% to 9E2, 68% to 9Z2 = XP_975385
CYP9Z15 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P941121
64 amino acids from heme to end
56% to 9V1, 56% to 9a20, 55% to 9G3, 64% to 9Z10
62% to 9Z1 = XP_975381, 65% to 9Z4
CYP9Z16 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P945125
73 amino acids from heme to end
53% to 9V1, 48% to 9a20, 46% to 9E2
56% to 9Z2 = XP_975385, 66% to 9Z8
CYP9Z17 Ips pini (pine engraver, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
61% to 9Z14 Colorado potato beetle (C-term piece), 55% to 9Z18
clone name EST 9D04
CYP9Z18 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
55% to 9Z17
clone name EST MPB1G10
CYP9Z18 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
Clone name DPO1028_G02
CYP9Z18 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP9J-2
93% to CYP9Z18 Dendroctonus ponderosae DPO1028_G02 probable ortholog
57% to CYP9Z20v1
CYP9Z19 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
57% to CYP9Z18
50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO1029_P08
CYP9Z20 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
57% to CYP9Z18
59% to DPO1029_P08, 59% to DPO1017_C19
58% to DPO111_E18, 57% to DPO1028_G02
56% to DPO1119_I16, 58% to DPO1021_H21
54% to CYP9Z2, 53% to CYP9Z4,
50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO042_F03
CYP9Z20v1 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP9RH1-1
94% to CYP9Z20 Dendroctonus ponderosae (probable ortholog)
98% to CYP9Z20v2
CYP9Z20v2 Dendroctonus rhizophagus
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee May 20, 2010
Clone name CYP9RH1-2
94% to CYP9Z20 Dendroctonus ponderosae (probable ortholog)
98% to CYP9Z20v1
CYP9Z20v3 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP9J-1
99% to CYP9Z20v4
98% to CYP9Z20v2
CYP9Z20v4 Dendroctonus valens
No accession number
Claudia Cano Ramirez
Submitted to nomenclature committee June 8, 2010
Clone name CYP9J-2
97% to CYP9Z20v2
CYP9Z21 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
54% to CYP9Z18
51% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO1119_I16
CYP9Z22 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
55% to CYP9Z18
49% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO1021_H21
CYP9Z23 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
54% to CYP9Z18
50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO111_E18
CYP9Z24 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
54% to CYP9Z18
50% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO1017_C19
CYP9Z25 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z26 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z27 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z28 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z29 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z30 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z31 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP9Z32 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
55% to CYP9Z25 Leptinotarsa decemlineata
missing N- and C-terminals
CYP9Z33 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
60% to CYP9Z20 Dendroctonus ponderosae
missing N- and C-terminals
CYP9Z34 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
95% to CYP9Z23 Dendroctonus ponderosae
CYP9Z35 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
91% to CYP9Z21 Dendroctonus ponderosae
CYP9Z36 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
93% to CYP9Z19 Dendroctonus ponderosae
CYP9Z37 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
79% to CYP9Z19 Dendroctonus ponderosae
CYP9Z38 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
80% to CYP9Z22 Dendroctonus ponderosae
CYP9Z fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP3 clan
Clone name seq 46
60% to CYP9Z4 Tribolium
short internal seq, probably belongs to CYP9Z8-9Z16 C-terms
CYP9AA1 Tribolium castaneum
GenEMBL XP_972755
52% to 9Z5
MWWLLIAAFTLLYALYIRLKKKNEYWIKKGVKQGSPVLIFGDKWRAIAHNESLADMVQKIYNVGPGDRYC
GAYDFMSPALVLKDPELIKDILVKDFDHFVDHKRVIPEGSDPIWDKNLFFLTGQKWRDMRSTLSPVFTGS
KMRFMFNLIAKSADQFVQHFVKQEETLIQIEMKDACARLTNDIIASTVFGFESDSVEDPDSKFYEMARKI
TDFSGLWQGLKILGFFIFPKYFENQNLSTEISNFFYNIVKENIRSRQLQNISRPDMISLLMEARENHKLI
HGVEISDEDVTAQALVFFFAGFDSVSSLMTFMSYELALNPEIQKKLIEEIDTTTKTLDYDVVKSMKYLDM
VVSETLRKWPITPFVNRVCTIPYTVQPKRPDENPIHLKKDAIVFLPIYGLHHDPKYFKDPERFDPERFSD
ENKAKIVPYTYVPFGAGPRKCIGYRFALLEIKILFFFLLSKFEIVTVDRTEIPVKICKKALNMTPEGGLW
LGLKPRK
CYP9AB1 Tribolium castaneum
GenEMBL XP_972546
51% to 9Z4
MWWFFVLLLGAPIVFFIFLYRTQKHWERRGLKQKNMGVTIPDNWAETKYPITFPDYVQKFYEMFPNRRYV
GYYTISNPSLFIRDLDLIKQIIVKDFEYFTDHQHFIWEENDPLWSQNLFSLKGKKWREMRTTLSPTFTSS
KIKYMFTLVQKNGEQFARYFLDKNENFMVFEMKDIFTRFTNDVIASSAFGVECDSLREPQNEFYLMSKAV
TDFTGLWKIVAGTFYFLMPSVAKFLNISLFPKKGSKFFSNLVKSNIKSRLQHGIVRPDMINIMLEARKHG
LKHEETQPSQDTGFATIEESELGKSGKVKKEITDDDITSQALVFIFAGFETVSSMMCFLSYELALNPDIQ
KRLIQEIDQTLDACGGSITYESLMGMKYLDMVLTESLRKWPISAGLDRVCTKEYVIEPKLPGENPVRVDK
GTTILVPVYALLRDPKYFPNPEKFDPERFSDENKGKIVPYTFLPFGAGPRSCIGTRFAIMETKVLFFSIL
RHFEIVRVEKTAVPIRYIPQQITLSSADGFWLGFKRRVKV
CYP9AC1 Tribolium castaneum
GenEMBL XP_969007
50% to 9Z2
MINMNYMITKHNKEQKNHGNKIQQHRKRITGTIYLGIFCAIFGYFYYYVKRQQNVWHQKGIKYCKPKFLL
GSLEIIRSKSLAQIIQELYNAFPEERYHGFYQFLLPTLIIKDPDLIKQITIKDFDHFVNHRRFVNADDDP
FWSRNLRGILVFARRDEKWRDMRATLSPSFTSSKMRIMFELMDECAREFVQHFKSQNSDTVELEMKDTLR
RFTNDVIASTAFGLKINSLKDRKNEFLLMGAAATDFGYIRTMKFLLYTLSPKLCQLLKMKIIPTKVADFF
TVIIKDTIKKRKEKNIIRPDMIHLLLEAQKGRQHPEEHLDIDEGFSSVSESKLTKPNEKLEITTEDIISQ
ALIFFLAGFDTVSTLLNFLFYELAVNPDVQTRLRTEIQSVDEKITYETLLKLKYLDMVMSEALRKWPPAI
ATDREVAKNYTIEPTKPDEKPLLLEEGMLCSIPICAIHRDEKYYPEPEKFDPERFNDENKHKINPLTFIP
FGAGPRNCIGSRFALLESKLLVFHVVKNFEIVPIDKTLIPLVMDKYQINWSVKGGTWLGLKNI
CYP9AD1 Tribolium castaneum
GenEMBL XP_973619
49% to 9Z2, gene model shortened at N-term
MLLLLLGTLIVILVLYLVNLSTKNFDHWEKRRVKYVKPFPFVGNLLPTVLKTKSTA
ELIQHLYKAFPNERFVGIFQFNTPILLIRDPELIKSIAIKNFDNFVDHYGFANDDIDPLWAKNLFASQGE
RWRDLRQTLSPVFTSSKMRTMFVLMDECVKQLTEYFKDQKQDVIDIELKDIFSRYTTDVIATTAFGIKVD
SLRNRNNDFVVSGREFTDFSGLRGLAFFINGSYPRLAKFLNIKIVSDRLGNFFRTIIKETLTLREEKKIV
RPDLIHSLMLARKGKLKYEELMELPEAGFAAVEESNLTKSNNNVNFLTDEDITAQALVFFLGGFDTTSSL
MCFAGYELAINPHIQKRLKDEVLATDRECNGQITYEKLLNMKYLDMVVSETLRKWNQAVWLDRKCTKEIE
IESETSGEPSVTLKVGDIIWMPAYAIHHDPKYYPNPELFDPERFSDENKDKIRTGTYLPFGVGPRNCIGS
RFALLETKLLLYNLLLNFDLVTNHKTENPIKLRRDTPLLMPQNGFQVSLRKNDAFSEK
CYP9AE1 Aedes aegypti
CYP9AF1 Tribolium castaneum
GenEMBL XP_972495, AAJJ01001543.1
56% to 9Z14 (potato beetle C-term fragment)
46% to 9D4
deletion in mid region
MLLSLFAVFLSVLIFFKFVSPCTYWKEKGVKHAQAWPFIGSMGRVFFKKQPYVEFLTELYNKFPNER (2)
YVGFMKFTQNHILIRDIELIGKITGKEFNFFTDRTVSSRLRKDKILSQSLISLTGDHWRD
MRATLSPAFTSNRTRNLYTFIETCARNFVNHYKAEVEIEVKEVFAKFANDVIASVAFSTELNSLKEPNDFYTN
ASQLKPDFFKQFI
TTSDKNRQDLISLLKDESLKFETYKRAKGEGFAIGEEPQIDPLSRKIQLTDEQI
LAQALLFFLTGFETISTSASFLAYELAVNLDVQKKLQREIDKVVQITGDRIPYDALLSMKYLDQVISESL
17091 RKWPPKFETDRVCTRDYHIKAQKGEKSLLIRKGMSVVIPIMAIHRDPDYYPNPNRFDPERFSDENRDKVV
PGTYLPFGAGPRNCI (1)
GARLALLEMKTVFGYLLAKFDIVQAKKTQMPIKLSAKCLDMEPEEGFWLGFRPRN 17561
CYP9AG1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG2 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG6 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG7 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AG8P Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH2 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH3 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH4 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH4-de1b Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH5 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH6 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AH7 Nasonia vitripennis (jewel wasp)
See wasp page
CYP9AJ1 Bombyx mori (silkworm)
no accession number
see silkworm page for details
CYP9AJ1 Antheraea mylitta (wild silkmoth) from fat body
EB742536.1
76% to CYP9AJ1
renamed as an ortholog, formerly CYPCYP9AJ2
RYFGLYQYLVPTLVPRDPELIRQIMVRDFHAFADRGVHISADCDPLFGRNLIMLT
GSNWRSMRVSLSPAFSGARCRCMAPLMADTARAVAQHLKHHITHEQLIDINT
ITMAYVNDVIASCAFGFAVNSLEDLQ
NGIFRLGQRAIVQDTT
CYP9AJ1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_190 69% to CYP9AJ1, 39% to CYP9P22
HAH015123 1 aa diff to Contig_190
renamed as an ortholog, formerly CYPCYP9AJ3
CYP9AJ1v1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
renamed as an ortholog, formerly CYPCYP9AJ4v1
CYP9AJ1v2 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
renamed as an ortholog, formerly CYPCYP9AJ4v2
CYP9AK1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee on Dec. 18, 2007
Clone name Luce0072E07
51% identical to Dm CYP9f2
153 aa at C-term
CYP9AL1 Culex pipiens
CYP9AM1 Culex pipiens
CYP9AN1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
49% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO0410_B16
CYP9AP1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
44% to CYP9Z4
41% to CYP9V1 Leptinotarsa decemlineata(Colorado potato beetle)
clone name DPO1319_O05
CYP9AQ1 Locusta migratoria manilensis
No accession number
Rongrong Yu
Submitted to nomenclature committee Dec. 12, 2010
49% to CYP9E1 Diploptera punctata
CYP9AQ2 Locusta migratoria manilensis
No accession number
Yanqiong Guo
Submitted to nomenclature committee Aug. 17, 2011
61% to CYP9AQ1 Locusta migratoria
CYP9AR1 Pediculus humanus humanus (body louse)
CYP9AR2 Pediculus humanus humanus (body louse)
CYP9AS1 Linepithema humile (argentine ant)
No accession number
CYP9AS2 Linepithema humile (argentine ant)
No accession number
CYP9AS3 Linepithema humile (argentine ant)
No accession number
CYP9AS4 Linepithema humile (argentine ant)
No accession number
CYP9AS5 Linepithema humile (argentine ant)
No accession number
CYP9AS6 Linepithema humile (argentine ant)
No accession number
CYP9AS7P Linepithema humile (argentine ant)
No accession number
CYP9AS8 Linepithema humile (argentine ant)
No accession number
CYP9AS9 Linepithema humile (argentine ant)
No accession number
CYP9AS10P Linepithema humile (argentine ant)
No accession number
CYP9AS11v1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP9AS1 Linepithema humile
CYP9AS11v2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP9AS1 Linepithema humile
CYP9AS12Pv1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
50% to CYP9AS6 Linepithema humile
CYP9AS12Pv2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
49% to CYP9AS4 Linepithema humile
CYP9AS13v1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
67% to CYP9AS8 Linepithema humile
CYP9AS13v2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
67% to CYP9AS5 Linepithema humile
CYP9AS14v1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
69% to CYP9AS5 Linepithema humile
CYP9AS14v2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
69% to CYP9AS5 Linepithema humile
CYP9AS14v3 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
69% to CYP9AS5 Linepithema humile
CYP9AS15Pv1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
60% to CYP9AS8 Linepithema humile
CYP9AS15Pv2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
64% to CYP9AS8 Linepithema humile
CYP9AT1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
48% to CYP9J16 Aedes aegypti
CYP9AT2 Chironomus riparius(aquatic midge)
No accession number
Jinhee Choi
Submitted to nomenclature committee Dec. 1, 2011
55% to CYP9AT1 Chironomus tentans
CYP9AU1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
42% to CYP9J24 Aedes aegypti
CYP9AV1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
46% to CYP9Z17
CYP9AV1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
100% to CYP9AV1
complete seq.
CYP9AW1 Agrilus (Emerald ash borer)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Nov. 10, 2011
49% to CYP9Z4 Tribolium
CYP9AX1 Coptotermes formosanus (termite)
GenEMBL JN969113 (March 2012)
Qinggang Xu
Submitted to nomenclature committee Nov. 22, 2011
51% to CYP9E2 Blatella germanica
CYP9AY1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
46% to CYP9Z2 Tribolium
nearly complete seq.
CYP9AZ1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
50% to CYP9Z19 Dendroctonus ponderosae
CYP9 fragment? Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-9
53% to CYP9P5 Nasonia, 53% to 9J7 Aedes aegypti
52% to CYP6DB2 whitefly Trialeurodes vaporariorum
Too short to name yet.