P450s that have appeared since the 1993 P450 nomenclature update.
This is part E of the bibiographic P450 files.
This section contains bacterial sequences CYP101 to CYP174.
This includes references that were incomplete and duplications
of sequences that were already in the update. If a sequence
is assigned an accession number that was not in the old update
it is included in this list. 48 new P450s were added July 27, 2000
Four new sequences were added Jan. 9, 2001 CYP102C1, CYP172-174.
Added CYP175A1 9/17/2001
Compiled by David R. Nelson
Last modified June 2, 2003 added 25 new sequences.
Last modified Nov. 5, 2003 There are now 501 bacterial P450s
Last modified Dec. 2, 2003 added 4 seqs in CYP153 family
Last modified Feb. 23, 2005 added 26 seqs from Rhodococcus sp. RHA1
Last modified Feb. 23, 2005 added 155C1 and 155C2
Last modified Sept. 20, 2005 added 18 Sorangium cellulosum seqs.
Last modified Nov. 17, 2006
Last modified Dec. 31, 2007
Last modified Aug. 19, 2009
Last modified Sept. 4, 2009 added four archaeal P450s
Last modified June 22, 2010
51 Family
101 Family
102 Family
103 Family
104 Family
105A Subfamily
105B Subfamily
105C Subfamily
105D Subfamily
105E Subfamily
106 Family
107A Subfamily
107B Subfamily
107C Subfamily
107D Subfamily
107E Subfamily
107F Subfamily
107G Subfamily
107H Subfamily
107J Subfamily
108 Family
109 Family
110 Family
111 Family
112 Family
113A Subfamily
113B Subfamily
114 Family
115 Family
116 Family
117 Family
118 Family
119 Family
120 Family
121 Family
122 Family
123 Family
124 Family
125 Family
126 Family
127 Family
128 Family
129 Family
130 Family
131 Family
132 Family
133 Family
51 Family
A note on nomenclature. CYP51s were originally all called CYP51, because only one
gene was found per species and they all seemed to be in this one conserved family.
However, rice had many CYP51s in at least two sequence groups, so subfamilies
have been designated for CYP51s. These are not the typical subfamilies, but only
one subfamily is created for each major taxonomic group. CYP51A for animals,
CYP51B for bacteria. CYP51C for Chromista, CYP51D for Dictyostelium, CYP51E
for Euglenozoa, CYP51F for fungi. Those groups with only one CYP51 per species
are all called by one name: CYP51A1 is for all animal CYP51s since they are
orthologous. The same is true for CYP51B, C, D, E and F. CYP51G (green plants)
and CYP51Hs (monocots only so far) have individual sequence numbers.
CYP51B1 Mycobacterium tuberculosis (Actinobacteria)
GenEMBL Z80226 (34809bp) gi 1550642 Rv0764c
complement (6140-7495)
33.7% identical to CYP51 over 439AA overlap
this is a bacterial CYP51
CYP51B1 Mycobacterium marinum
No accession number
Tim Stinear
MM4932
82% to 51B1 M. tuberculosis
CYP51B1 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to CYP51B1 Mycobacterium marinum = ortholog
CYP51B1 Mycobacterium bovis subsp. bovis AF2122/97 (Actinobacteria)
NC_002945 complete genome complement(858662..858868)
CYP51 100% match
locus_tag = Mb0786c
CYP51B1 Mycobacterium avium (Actinobacteria)
TIGR contig:3273:m_avium Length = 5,475,738
79% to CYP51 M. tuberculosis
3021360 TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 3021539
3021540 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 3021719
3021720 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 3021899
3021900 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 3022079
3022080 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 3022259
3022260 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 3022439
3022440 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 3022619
3022620 PADSYRNDHSKMVVQLARPAKVRYRKR 3022700
CYP51B1 Mycobacterium smegmatis (Actinobacteria)
TIGR contig:3439:m_smegmatis Length = 6,989,783
80% to CYP51 M. tuberculosis
4858809 VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS 4858988
4858989 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV 4859168
4859169 ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 4859348
4859349 LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 4859528
4859529 VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 4859708
4859709 NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 4859888
4859889 DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 4860068
4860069 YRNDHSKMVVQLARPAKVRYRRR 4860137
CYP51B1 Methylococcus capsulatus (Proteobacteria)
TIGR contig:221:m_capsulatus
49% to CYP51 M. tuberculosis
NOTE FUSION PROTEIN EXTENDS C-TERMINAL.
SEE J. Biol. Chem., Vol. 277, Issue 49, 46959-46965, December 6, 2002
A Novel Sterol 14-Demethylase/Ferredoxin Fusion Protein (MCCYP51FX)
From Methylococcus capsulatus Represents a New Class of the Cytochrome
P450 Superfamily
Colin J. Jackson, David C. Lamb, Timothy H. Marczylo, Andrew G. S.
Warrilow, Nigel J. Manning, David J. Lowe, Diane E. Kelly, and Steven
L. Kelly
908332 MSHPPSNTP
908305 PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 908126
908125 DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 907946
907945 LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 907766
907765 NLPLPVFKRRDQARVRLQELVTQIMERRARSQERSTNVFQMLIDASYDDGSKLTPH 907598
907597 EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 907418
907417 PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 907238
907237 FDPDRYTPERAEDKDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE 907061
907060 SYRDDYRKMVVEPASPCLIRYRRRDAP 906980
CYP51B1 Rhodococcus sp. RHA1 (Actinobacteria)
No accession number
Marianna A. Patrauchan
Rha05830
Submitted to nomenclature committee 12/13/04
77% to CYP51B1 M. avium or M. tuberculosis
CYP51B1 Rhodococcus sp. R04
AFAQ01001981 14835-16172 (+) strand
Riu Xue
Submitted to nomenclature committee Dec. 26, 2011
85% to CYP51B1 Rhodococcus sp. RHA1
CYP51B1 Nocardia farcinica IFM 10152 (Actinobacteria)
GenEMBL AP006618.1
CDS complement(2757924..2759282)
MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFE
LAGKQVILLSGAEANEFFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHN
SALRAEQMRGHATTIAAEVDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNE
LDDRFARLYHELERGTDALAYVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPA
DKSDRDLLDVLVSVPNEDGGPRFSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHP
ELRDRVVAELDELFADGKDVSFHALRQIPLLEATLKETLRMHPPLIILMRVAQGDFEV
CGHHIAAGDHVAATPAISNRLPEDFPDPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRH
RCVGAAFALMQLKAIFSILLRDWEFEMAQPSESYRNDHSKMVVQLQQPCRVRYRRRVR
TS
CYP51B1 Mycobacterium vanbaalenii
ZP_01207535.1, AAT40578.1, EAS23094.1
Q5IZM4CP51_MYCVN Cytochrome P450 51 (CYPLI) (P450-LIA1) (Sterol 14-alpha
80% TO CYP51 Mycobacterium tuberculosis
MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSE LNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEF FAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVM HGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFY AKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASP AISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM AQPPESYQNDHSKMVVQLARPAKVRYRRRVRD
101 Family
CYP101A1 Pseudomonas putida
GenEMBL D00528 (1950bp)
Koga,H., Yamaguchi,E., Matsunaga,K., Aramaki,H. and Horiuchi,T.
Cloning and nucleotide sequences of NADH-putidaredoxin reductase
gene(camA) and putidaredoxin gene(camB) involved in cytochrome
P-450cam hydroxylase of Pseudomonas putida
J. Biochem. 106, 831-836 (1989)
Note: only the last 93 nucleotides of the cam gene was cloned along
with two downstream genes.
CYP101A1 Pseudomonas putida
PIR C60886 (last 8 amino acids)
Romeo, C., Moriwaki, N., Yasunobu, K.T., Gunsalus, I.C.,
Koga, H.
Identification of the coding region for the putidaredoxin
reductase gene from the plasmid of Pseudomonas putida.
J. Protein Chem. 6, 253-261 (1987)
CYP101B1 Novosphingobium aromaticivorans
NZ_AAAV01000165.1
complement(29626..30870) gene = Saro2804
43% to CYP101
MLPHDRGQNSTRRITAMEAPAHVPADRVVDIDIYMPPGLAEHGF
HKAWSDLSAGNPAVVWTPRNEGHWIALGGEALQEVQSDPERFSSRIIVLPKSVGEMHG
LIPTTIDPPEHRPYRQLLNAHLNPGAIRGLSESIRQTAVDLIEGFAAQGHCNFTAQYA
EQFPIRVFMALVGIEASEAPRIRHWAECMTRPGMDMTFDEAKAVFFDYVGPLVDARRE
TPGEDMISAMINADLGDGRRLTRDEALSVVTQVLIAGLDTVVNVLGFIMRELAGNPAL
RADLRQRGADILPVVHELFRRFGLVSIAREVRRDIEFHGVHLKAGDMIAIPTQVHGLD
PRVNPDPLAIDPSRKRARHSTFGSGPHMCPGQELARKEVAITLEEWLRRIPDFALGPN
SDLSPVPGIVGALRRVELVWNT
CYP101C1 Novosphingobium aromaticivorans
NZ_AAAV01000133.1
complement(4199..5389) gene = Saro1574
44% to CYP101A1
MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTA
NGGHWIAARGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVM
KGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR
PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRP
WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLIPAAADELMR
RYPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIR
HTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPL
VWRA
CYP101D1 Novosphingobium aromaticivorans
NZ_AAAV01000085.1
complement(6803..8068) gene = Saro0669
44% to CYP101
MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAW
KRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVP
TKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVF
PVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAA
RRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP
ETVAEMRREPLKLQRGVEELFRRFAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHG
LDDRHHDDPMTVDLSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLK
DRAVPIYHSGIVAAVENIPLEWEPQRVSA
CYP101D2 Novosphingobium aromaticivorans
NZ_AAAV01000042
complement(5601..6899) gene = Saro0208
63% to 101D1
MGTTRMDTFNPQESRLATNFDEAVRAKVERPANVPEDRVYEIDM
YALNGIEDGYHEAWKKVQHPGIPDLIWTPFTGGHWIATNGDTVKEVYSDPTRFSSEVI
FLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA
RGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAG
NNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVV
NFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFPVVSEARMVAKDQEYKGVFL
KRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGGPHRCAGMHLARMEVIVT
LEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR
CYP101D3 Sphingomonas sp. SKA58
ZP_01304513
78% to CYP101D2
1 MPEHVPETMS RARAPRPEHI PEQYVHEIDM YALEGIEQGY HEAWKNIPKP DMPDLIWTPF
61 TGGHWIATNG DTVREVYSDP TRFSSEVIFL PKEAGEKYEM VPTRMDPPEH TPYRKALDKG
121 LSLAQIRKVE SKVRKVAVDL IDSFVSRGEC DFSAEYANVF PVRVFMALAD LPESDVPTLS
181 RFAKMMTRPE GNTPEEMAKH LEEGNKGFFA YVEPIIQARR GKEGEDLITV MVNAEINGER
241 ITHDKALGLI SLLLLGGLDT VVNFLSFMMI HLAKNPQVVE ELRADPLKLM RSAEEMFRRF
301 PVVSEARMVA KDQDFRGIEL KRGDMILLPT ALHGLDDQLN DDPWRINLER RGISHSTFGG
361 GPHRCAGLHL ARMEVIVTIE EWLKRIPTFA MKPGAQPIYH SGIVAAVDNV PLIWSER
102 Family
CYP102A1 Bacillus megaterium
Ruettinger,R.T.,Wen, L.-P. and Fulco, A.J.
Coding Nucleotide, 5'-Regulatory, and Deduced Amino Acid Sequences of
P450BM-3, a Single Peptide Cytochrome P450:NADPH-P450 Reductase from
Bacillus megaterium.
J. Biol. Chem. 264, 10987-10995 (1989)
CYP102A1 Bacillus megaterium
GenEMBL J04832 (4957bp)
Ravichandran,K.G., Boddupalli, S.S., Hasemann,C.A.,
Peterson,J.A. and Deisenhofer,J.
Crystal structure of hemoprotein domain of P450BM-3, a prototype
for microsomal P450s.
Science 261, 731-736 (1993)
P450 is N-terminal
CYP102A2 Bacillus subtilis
GenEMBL D87979
Yamamoto, H., S. Uchiyama, F. A. Nugroho, and J. Sekiguchi.
A 23.4 kb segment at the 69 degrees-70 degrees region of the
Bacillus subtilis genome.
Microbiology. 143, 1317-20 (1997)
Gene name yfnJ 66.4% identical to CYP102A1 P450 part only
also called YetO (fusion of P450 and reductase like CYP102A1, P450 part is
N-terminal)
CYP102A3 Bacillus subtilis
GenEMBL U93874, Z99117
Sorokin, A., A. Bolotin, B. Purnelle, H. Hilbert, J. Lauber, A.
Dusterhoft, and S. D. Ehrlich.
Sequence of the Bacillus subtilis genome region in the vicinity of
the lev operon reveals two new extracytoplasmic function RNA
polymerase sigma factors SigV and SigZ.
Microbiology. 143, 2939-43 (1997)
Gene name yrhJ most similar to CYP102A2
(fusion of P450 and reductase like CYP102A1 P450 part is N-
terminal)
CYP102A4 Bacillus anthracis str. Ames
GenPept AAP27014
bifunctional P-450:NADPH-P450 reductase 1
79% to 102A2
1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFRMQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETQEPNWQ KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YEEYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKNHEIKQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVAAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKG DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQRMWSDAMK VFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF EPFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNVGEAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGQAKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI
CYP102A5 Bacillus cereus ATCC 14579
GenPept AAP10153
NADPH-cytochrome P450 reductase/P450 fusion
79% to 102A2 Bacillus subtilis
1 MEKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKIAEEYG PIFQIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG DQEENDLLSR
241 MLNVPDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYMRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFELID YQNYQLDVKQ TLTLKPGDFK IRILPRKQTI SHPTVLAPTE DKLKNDEIKQ
481 HVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSKRGEADAS GDFEEQLEQW KQNMWSDAMK AFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSDRSTRHIE VSLPEGATYK EGDHLGVLPV
721 NSEKNINRIL KRFGLNGKDQ VILSASGRSI NHIPLDSPVS LLALLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELEALL EEGVYHEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAHNRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFELPKDP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNLGQAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQDEGRYGKD VWAGI
CYP102A6 Bradyrhizobium japonicum USDA 110
GenPept BAC48147
NC_004463 complete genome 3173438..3176674
NADPH-cytochrome P450 reductase/P450 fusion
54% to 102A2
1 MSSKNRLDPI PQPPTKPVVG NMLSLDSAAP VQHLTRLAKE LGPIFWLDMM GSPIVVVSGH
61 DLVDELSDEK RFDKTVRGAL RRVRAVGGDG LFTADTREPN WSKAHNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVQKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPFEQI WMQKRRKTLA EDVAFMNKMV DEIIAERRKS AEGIDDKKDM
241 LAAMMTGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYTLYALLKH PDILKKAYDE
301 VDRVFGPDVN AKPTYQQVTQ LTYITQILKE ALRLWPPAPA YGISPLADET IGGGKYKLRK
361 GTFITILVTA LHRDPSVWGP NPDAFDPENF SREAEAKRPI NAWKPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQMHLKETL TMKPEGFKIK VRPRADRERG AYGGPVAAVS
481 SAPRAPRQPT ARPGHNTPML VLYGSNLGTA EELATRMADL AEINGFAVHL GALDEYVGKL
541 PQEGGVLIIC ASYNGAPPDN ATQFVKWLGS DLPKDAFANV RYAVFGCGNS DWAATYQSVP
601 RFIDEQLSGH GARAVYPRGE GDARSDLDGQ FQKWFPAAAQ VATKEFGIDW NFTRTAEDDP
661 LYAIEPVAVT AVNTIVAQGG AVAMKVLVND ELQNKSGSNP SERSTRHIEV QLPSNITYRV
721 GDHLSVVPRN DPTLVDSVAR RFGFLPADQI RLQVAEGRRA QLPVGEAVSV GRLLSEFVEL
781 QQVATRKQIQ IMAEHTRCPV TKPKLLAFVG EEAEPAERYR TEILAMRKSV YDLLLEYPAC
841 ELPFHVYLEM LSLLAPRYYS ISSSPSVDPA RCSITVGVVE GPAASGRGVY KGICSNYLAN
901 RRASDAIYAT VRETKAGFRL PDDSSVPIIM IGPGTGLAPF RGFLQERAAR KAKGASLGPA
961 MLFFGCRHPD QDFLYADELK ALAASGVTEL FTAFSRADGP KTYVQHVLAA QKDKVWPLIE
1021 QGAIIYVCGD GGQMEPDVKA ALVAIRHEKS GSDTATAARW IEEMGATNRY VLDVWAGG
CYP102A7 Bacillus licheniformis ATCC 14580
GenEMBL AAU24352
Rey,M.W., Ramaiya,P., Nelson,B.A., Brody-Karpin,S.D.,
Zaretsky,E.J., Tang,M., de Leon,A.L., Xiang,H., Gusti,V.,
Clausen,I.G., Olsen,P.B., Rasmussen,M.D., Andersen,J.T.,
Jorgensen,P.L., Larsen,T.S., Sorokin,A., Bolotin,A., Lapidus,A.,
Galleron,N., Ehrlich,S.D. and Berka,R.M.
Complete genome sequence of the industrial bacterium Bacillus
licheniformis and comparisons with closely related Bacillus species
Genome Biol. 5 (10), R77 (2004)
74% to CYP102A3 for the P450 domain
1 MNKLDGIPIP KTYGPLGNLP LLDKNRVSQS LWKIADEMGP IFQFKFADAI GVFVSSHELV
61 KEVSEESRFD KNMGKGLLKV REFSGDGLFT SWTEEPNWRK AHNILLPSFS QKAMKGYHPM
121 MQDIAVQLIQ KWSRLNQDES IDVPDDMTRL TLDTIGLCGF NYRFNSFYRE GQHPFIESMV
181 RGLSEAMRQT KRFPLQDKLM IQTKRRFNSD VESMFSLVDR IIADRKQAES ESGNDLLSLM
241 LHAKDPETGE KLDDENIRYQ IITFLIAGHE TTSGLLSFAI YLLLKHPDKL KKAYEEADRV
301 LTDPVPSYKQ VQQLKYIRMI LNESIRLWPT APAFSLYAKE ETVIGGKYLI PKGQSVTVLI
361 PKLHRDQSVW GEDAEAFRPE RFEQMDSIPA HAYKPFGNGQ RACIGMQFAL HEATLVLGMI
421 LQYFDLEDHA NYQLKIKESL TLKPDGFTIR VRPRKKEAMT AMPGAQPEEN GRQEERPSAP
481 AAENTHGTPL LVLYGSNLGT AEEIAKELAE EAREQGFHSR TAELDQYAGA IPAEGAVIIV
541 TASYNGNPPD CAKEFVNWLE HDQTDDLRGV KYAVFGCGNR SWASTYQRIP RLIDSVLEKK
601 GAQRLHKLGE GDAGDDFEGQ FESWKYDLWP LLRTEFSLAE PEPNQTETDR QALSVEFVNA
661 PAASPLAKAY QVFTAKISAN RELQCEKSGR STRHIEISLP EGAAYQEGDH LGVLPQNSEV
721 LIGRVFQRFG LNGNEQILIS GRNQASHLPL ERPVHVKDLF QHCVELQEPA TRAQIRELAA
781 HTVCPPHQRE LEDLLKDDVY KDQVLNKRLT MLDLLEQYPA CELPFARFLA LLPPLKPRYY
841 SISSSPQLNP RQTSITVSVV SGPALSGRGH YKGVASNYLA GLEPGDAISC FIREPQSGFR
901 LPEDPETPVI MVGPGTGIAP YRGFLQARRI QRDAGVKLGE AHLYFGCRRP NEDFLYRDEL
961 EQAEKDGIVH LHTAFSRLEG RPKTYVQDLL REDAALLIHL LNEGGRLYVC GDGSRMAPAV
1021 EQALCEAYRI VQGASREESQ SWLSALLEEG RYAKDVWDGG VSQHNVKADC IART
CYP102A8 Bacillus thuringiensis serovar konkukian str. 97-27
AAT62301
98% to CYP102A4, 96% to CYP102A5
1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFQIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETDEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDDVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YEDYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKKHEIKK
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI
721 NNEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MKVGEAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI
CYP102A9 Bacillus weihenstephanensis KBAB4
ZP_01184381
96% to CYP102A5
1 MDKKVSAIPQ PKTYGLLGNL PLIDKDKPTL SFIKIAEEYG PIFRIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSYYR ETPHPFITSM
181 SRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKI PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YQDYQLDVKQ TLTLKPGDFK IRILPRNQTI SHTTVLAPIE EKLKNDEIEQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKS DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNI EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYQ EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVS LFDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELELLL EEGVYHEQIL KKRMSMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGVAPFRGFL QARRVQKQKG INLGQAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHIAF SRLEGYPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQEEGRYGKD VWAGI
CYP102A10 Erythrobacter litoralis HTCC2594
YP_456909
60% to 102A6
1 MDAPTALAPI PQPPGKPIVG NAFTVDSSRL IQSLMELAEE YGPIFQLEVM GTPLVFVSGA
61 DMVAEICDES RFDKTVRGPL KRLRLIAGDG LFTGDTDDPN WAKAHHILLP SFSQKAMGSY
121 LPMMTDIASQ LMLKWERLNS DDVIDVPMDM VRLTLDTIGV CGFGYRFNSF YREDFHPFIE
181 ALNRTLDTTQ KMRGLPGEKL LKRQQIEQLN EDAAYMNNLV DEIIRERRQT GESGQGDLLD
241 FMLSGRDPVT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLQRAYAEVD
301 EVLGRNIDQT PTLSQIGRLP YIRAILSEAL RLWPTAPAMG LAPFEDEVLG GKYAIAKGTF
361 TTVLIPSLHR DKLVWGENPE AFNPDNFSPK AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLGMLLQR FELFDHADYQ LRIKETLSIK PDGFTIKARL RHDVERGGVA TVEPESKTPD
481 QAAAVPSHGT PLLVLYGSNL GSSEGFAREL AQRGEFSGFD VTMAPLDAHV AKLPTDGAVA
541 IACASYNGMP PDNAAKFVDW LEQADAADAP LSNVSYLVLG CGNSDWAATF QVVPRKIDAL
601 MEQHGAERLV PAEELDARGD LDTQFHDWLD GLIPQLGDAF DIDLESGFDA VFEPLYTVEI
661 TDSITGNTVA DRVGAREVEV VANRELKDTS KDEGRSTRHL EVRLPEGMEY EPGDHLCVVP
721 VNDPAVVDRL LKRFGLDRDT FVRIESRSDM RGPFPSGSTF SVLNLAETAG ELQAVATRKD
781 IATLARYSEC PNSRAALEAL AAPPSADGTD RYTSEVLEKR RSVLDMLEEF PACDVPLAVF
841 LELIPFLSPR YYSISSAPEA NQGLCSITVG VVKGPALAGT GEFKGTCSAY LADLPPGDRF
901 RAVVRKPTAQ FRLPDNPETP VIMIGPGTGV APFRAFLQRR DHLQEDGAVL GEAMLFFGCR
961 HPDIDYLYRE ELDDYDQRGV ATVHAAFSRH DGSRTYVQDL IAREADRVWE LIEQDARIYV
1021 CGDGARMEPD VRKALMAIYA EKKSSDEASA KAWIDDLVAQ DRYLLDVWVG
CYP102A11 Erythrobacter sp. NAP1
ZP_01041731
75% to CYP102A10
1 MATNATLTPI PQPPGKPLIG NALTVDASQQ IQSLMELAEE YGPIFQLDMM GTPIVIISGA
61 DLVAEVCDEK RFDKSVRGPL KRLRLIGGDG LFTGDTDAPN WSKAHNILLP SFSQKAMGSY
121 LPMMTDIATQ LVMKWERMNS DDVIDVPKDM IRLTLDTIGV CGFGYRFNSF YREDFHPFIR
181 ALTRTLETTQ KIRGIPGEKL LKGDAVKQLH RDAKYMNNLV DEIIRERQRS GGDGPEDLLD
241 FMLSGRDPLT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLTRAYAEVD
301 TVLGRNIDQP PSLKQIGQLP YIRAILFEAL RLWPTAPAFG LAPFEDEVLG GKYLIPKGTF
361 TTVLIPSLHR DKSVWGENPE VFDPENFTAE AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLAMILQR FELFDHSDYK LDIKETLSIK PDEFTIKARM RKDVERGGKA TEDAEEASTE
481 PAEPKVPKHD TPLLVLYGSN LGSSESFARE VAQKGEFSGF EVEMAPLDDY VGKLPEDGAV
541 AIACASYNGM PPDNAAKFID WIEGKDGAAP DLSGVSYMML GCGNSDWAAT FQAVPRLIDA
601 RMEELGAKRI VPTTELDARS DVDTQFHTWL DALMPQLGEH FDLDLSGEAA GIAEPLYKVE
661 VTQSVTANTV ASRVGAHAVK MVANRELKNT DIGEGRSTRH IEVELAQGET YQPGDHLCVV
721 PENDDAVVER LLRRFNLDAD TYVRIESRSE MRGPFPSGST FSVYNLAKTA GELQAVATRK
781 DIATLALYTE CPNSKPALEK LAQPPQEDGT DQYATDVLAK RKSVLDLLED YPACDLPLAV
841 FLEMIPFLSP RYYSISSAPG DTPQTCSITV GVVKGPALSG KGTFKGTCSN YLAELEPGAS
901 FNAVVREPTA NFRLPDDPKV PLIMVGPGTG LAPFRGFLQE RDALASSGEE LGPARLYFGC
961 RTPDEDFLYR DELEDYDKRG IVTLRTAFSR VDEGKCYVQD HIADDADAIW EMLEAGGRIY
1021 VCGDGARMEP DVRAALAKIH SDKTGSTPAE AQSWVGDLIT NERYSLDVWV G
CYP102A12 Rhodopseudomonas palustris HaA2
YP_487251
84% to CYP102A6
1 MSSSNKLAPI PHPPKQPVVG NMLSIDTKAP VQHLVRLAEE LGPIFWLDMM GAPIVIVSGY
61 DLVDEISDEK RFDKAVRGAL RRVRTVGGDG LFTADTSEPN WSKAHNILLT PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRDTLA EDVAFMNAMV DEIIAERRKA AAVADKMDML
241 GAMMTGVDKV TGEPLDDVNI RYQINTFLIA GHETTSGLLS CAIYALLKHP EVLQKAYDEV
301 DRVLGADTSV EPSYQQVNQL GYITQILKET LRLWPPAPAY GVAPIQDETI GGQYHLKRGT
361 FTTVLVLALH RDPSIWGPNP DAFDPENFSR EAESKRPANA WKPFGNGQRA CIGRGFAMHE
421 AALALGMILQ RFKLIDHTRY RMVLKETLTI KPEGFKIKVR PRSDKDRATR IASGVSHSVA
481 PAPAAPRARP GHNTPLLVLY GSNLGTAEEL AHRVADLADL NGFATRLGAL DQYVGQLPEE
541 GGVLIFAASY NGAPPDNATQ FVRWLSGDLP PDAFAKLRYA VFGCGNRDWT ATYQAIPRLI
601 DERLAAHGGR NIFVRGEGDA RDDLEGQFEA WFATLGPLAV KEFGIDAAFD RGADDTPLYG
661 IEPLAPAASQ PLAATGVAVA MRVLENRELQ DRAASGRSTR HIEIALPQGM SYRVGDHLSV
721 IPRNDPALVA AVAQRFGFAP DDQIRLSAAP GRRAQLPVGE AVSIGGLLGD HVELQQVATR
781 KQIVALAAHT RCPQTRPKLQ ALAGGDGAAD DAYRAEVLGK RRSVFDLLQE HPACELPFAA
841 YLEMLTPLQP RYYSISSSPA RDPARASVTV AVVEGPALSG RGIYRGACSS WLAGRGSGDT
901 VQATVRATKA CFRLPDDDRV PLIMIGPGTG VAPFRGFLQE RSARKVGGAT LGPALLFFGC
961 RHPAQDYLYA DELQGFAADG IVELHAAFSR GDGPKTYVQH LIAAQKDRVF ALIEQGAIVY
1021 VCGDGGRMEP DVKAALCAIH RERSGADATA AAAWIADLGA RDRYVLDVWA SV
CYP102A13 Rhodopseudomonas palustris HaA2
YP_568957
87% to CYP102A12
1 MPSTNKLDPI PHPPKKPVVG NMLSLDTTAP VQHLVRLAKE LGPIFWLDMM GAPLVIVSGY
61 DLVDEISDEK RFDKAVRGAL RRARAVGGDG LFTADTKEPN WSKAHNILLT PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRETLA DDVVFMNAMV DEIIAERRKA SESAADKKDM
241 LGAMLAGVDR ATGEPLDDVN IRYQINTFLI AGHETTSGLL SCAIYALLKH PDVLQKAYDE
301 VDRVLGSDTA VRPSYQQVNQ LSYITQILKE TLRMWPPAPA YGVAPIKDEV IGGKYHLKRG
361 TFVTVLVLAL HRDPAIWGPN PDAFDPENFS REAESKRPAN AWKPFGNGQR ACIGRGFAMH
421 EAALALGMIL QRFQLIDHQR YRMVLKETLT IKPEGFKIKV RPRSDKDRGD FVAAGASQVS
481 TPALAQAAPR ARPDHNTPLL VLYGSNLGTA EELATRVADL AELNGFSTRL GALDQYVGHL
541 PEEGGVLIFT ASYNGAPPDN ATQFVQWLSG DLPKDAFAKL RYAVFGCGNR DWTATYQAIP
601 RLVDERLAAH GGRNIFLRGE GDARDDLEGQ FESWFAKLGP LAVKEFGIDA KFARAVDDAP
661 LYRIEPVAPA AGNAVAAAGG AVPMKVLANR ELQDCAASGR STRHIEIALP EGISYRVGDH
721 LSVMPRNDPA LVAAVAQRLG FAPDDQIKLQ VAPGRRAQLP IGEAISVGRL LGDFVELQQV
781 ATRKQIAVMA EHTRCPQTRP KLQALAGGDG AADEAYRAGV LAKRKSVYDL MQEHPACELP
841 LHAYLEMLSP LAPRYYSISS SPLRDPSRAA ITVAVVDGPA LSGRGHYRGV CSTWLAGRSV
901 GDTIHATVRA TKAGFRLPDD DRVPLIMIGP GTGLAPFRGF LQERAARQQN GATLGPALLF
961 FGCRHPAQDY LYADELQGFA AEGVVELHTA FSRGEGPKTY VQHLIAAQKD RVFTLIEQGA
1021 IIYVCGDGGK MEPDVRAALM AIHRERSGAD AAAASTWIDD LGACNRYVLD VWASA
CYP102A14 uncultured soil bacterium
ABD83817
74% to 102A12
1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE LGPIFWLDMM GAPIVIVSGY
61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA TDVAFMNKMV DEIVAERRKS AEASDGKKDM
241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYAIYALLKH PDVLKKAYAE
301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE ALRLWPPAPA YGIAPLKDET IAGGKYSLKK
361 NTFISILVTA LHHDPAVWGP NPDLFDPENF SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL TIKPDGFKIK VRPRSGHDRT VHAEAATAAV
481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA EDLATRVADL AEVNGFATRL APLDDCAGQL
541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG ELPNDAFAKL RYAVFGCGNR DWAATYQSVP
601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ FESWFAALGA AAVKEFGLES RFSRSADDAP
661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR ELQNKSGPDA SERSTRHIEV QLPGGMTYRV
721 GDHLSVVPCN APALVDRVAR RFGFLPADQI RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL
781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG DDADSSERYR ADILSRRKSV YDLLEEFPAI
841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS RCSITVGVVS CPASSTGRGL YRGVCPYYLA
901 SRREGESVFA TVRETKAGFR LPDDPSVPII MIGPGTGLAP FRGFLQERAA RKAGGATLGP
961 AMLFFGCRHP EQDYLYADEL KAFADEGITE LFVAFSRSEG PKTYVQHLLA TQKARVWDLI
1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC TGADANGGAK WIADLGAQNR YVLDVWAGG
CYP102A15 Bacillus pumilus ATCC 7061
ZP_03053227
61% to CYP102A3, 68% for the P450 portion
1 MQQTSIIPKP KTYGPFKNIP HIKKGELSQT FWRLADELGP IFQFEFSKAT SIFVSNHELF
61 QEICDESRFD KYIGTSLNKV RAFAGDGLFT SWTEEPNWRK AHHILMPAFS QQAMKGYHEM
121 MLDIATQLVQ KWQRTGRDEE IEVAEDMTKL TLDTIGLCGF DFRFNSFYKE NQHPFIESMV
181 NGLSEAMDQA SRLPVADKLM IKRRKKFEEN VDFMKQLVDD IIQERKKQDK TGDDLLSLML
241 HAKDPETGER LSDENIRYQI ITFLIAGHET TSGLLSFAIY FLLKNPEKLK KAVQEADDVL
301 QGGLPTFKQV QKLNYTRMVL NESLRLWPTA PTFSLYAKED TVIGGKYSIE KNQSVSVLLP
361 KLHRDQAVWG EDAEEFKPER FLHPEKIPQH AYKPFGNGQR ACIGMQFALH EATMVLAMVL
421 HNLELIDHTS YELDLKESLT IKPNDFKIKV RPRKQQLFMV PPKEETKKST TTDESKVKSH
481 GTPLLVLYGS NLGTAQQIAN ELAEEGKAKG FDVTTAPLDD YTRQLPDKGA VFIVTASYNG
541 HPPDHAKKFV DWVTQEKEQD LTNVTFAVFG CGDRNWASTY QRIPRLIDEA LERKGAKRAA
601 DLGEGDAGGD MDEDKEAFQK TVFKQLAKEF QLTFQEKGKE NPKLSVAYTN ELVERPVAKT
661 YGAFSAVVLK NEELQSEKSE RQTRHIELQL PEGKKYKEGD HIGIVPKNSD ALVQRVINRF
721 NLDPKQHIKL YSEKKANHLP LDQPIQMREL LASHVELQEP ATRTQLRELA AYTVCPPHRV
781 ELEQMAGEAY QEAILKKRVT MLDLLDQYEA CELSFVHFLA LLPGLKPRYY SISSSPKVDE
841 KRVSITVAVV KGKAWSGRGE YAGVASNYLC GLKEGEEVAC FLHEAQAGFQ LPPSSEVPMI
901 MIGPGTGIAP FRGFVQAREV WQKEGKPLGE AHLYFGCRHP HEDDLYFEEM QLAAQKGVVH
961 IHRAYSRHKE QKVYVQHLLK EDGGMLIKLL DQGAYLYVCG DGKVMAPDVE ATLIDLYQHE
1021 KQCSKEAAEN WLTTLANNNR YVKDVWS
CYP102A16 Bacillus sp. C3
FR775424
97% to CYP102A9 and 97% to CYP102A4
CYP102B1 Streptomyces coelicolor cosmid F43.
GenEMBL AL136502 CDS 10570..12153 gene="SCF43.12"
Highly similar to the N-terminal P450 domain of Bacillus
megaterium 41.9% identity in 497 aa overlap.
45% to 102A1 over 433 amino acids
cloned and expressed by David Lamb and Steve Kelly
CYP102B2 Streptomyces avermitilis
GenEMBL AP005050
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV7426
78% to 102B1 from Streptomyces coelicolor
CYP102B3 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05872
Submitted to nomenclature committee 12/13/04
62% to CYP102B2
CYP102B4 Streptomyces scabies
SCAB9321
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
80% to CYP102B2 Streptomyces avermitilis
CYP102C1 Rhodococcus sp. X309
GenEMBL AF059700.1 complement(3619-4584) runs off end of sequence
partial gene 48% to 102B1
CYP102C2 Rhodococcus erythropolis PR4
YP_345116
88% to CYP102C1
1 MNGPRGSRTR PRRASLVNLA VLGVVLVHTV LMSADKCPYP KSATRAGEIT AVQPQVFESI
61 PSPAWRLPLL GDLLTVDSEK PIQKEMALAS KLGPIFEWKI VNNRVTVVSG VDLVAEVNNE
121 ALWAKSVGLP ILKLRKVAED GLFTAFNSEP NWRKAHNILS EGFSRSALRN YHPSMLRALG
181 GLTDSWDRVA DAGETIDASS DANKLALDVI GLAGFGYDFA SFIGEEHPFV GAMSRVLAHV
241 NSTSNDIPFL RKLRGNGADL QNEKDIALLR TVVDNVIAER QSKPGEHQDD LLDLMLHSAD
301 AETGEKLDPV NIRNQVFTFL VAGNETTAGT LAFALYFLSR HPDVADTARA EVADVTAGET
361 PAFEDVARMR YLRRVVDETL RLWPSAPGYF RKVRTDTTLG GRYDMPKGSW VFVLLPQLHR
421 DPVWGEDPES FDPDRFKPEN VKKRPAHAYR PFGTGPRACI GRQFALHEAV LALAIILQRY
481 NFQSDPEYKL DIRETLSLKP VGFELSLQRR
CYP102C3 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
61% to CYP102C2 Rhodococcus erythropolis PR4
CYP102D1 Streptomyces avermitilis
GenEMBL AP005023
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV575 47% to 102A3
40% to 102B1, 44% to 102C1 partial seq
CYP102E1 Ralstonia metallidurans
GenEMBL NZ_AAAI01000371
104500-107000 region
51% to 102D1
MSTATPAAALEPIPRDPGWPIFGNLFQITPGEVGQHLLARSRHHDGIFELDFAGKRVPFVS
SVALASELCDATRFRKIIGPPLSYLRDMAGDGLFTAHSDEPNWGCAHRILMPAFSQRAM
KAYFDVMLRVANRLVDKWDRQGPDADIAVADDMTRLTLDTIALAGFGYDFASFASDELDP
FVMAMVGALGEAMQKLTRLPIQDRFMGRAHRQAAEDIAYMRNLVDDVIRQRRVSPTSGMD
LLNLMLEARDPETDRRLDDANIRNQVITFLIAGHETTSGLLTFALYELLRNPGVLAQAY
AEVDTVLPGDALPVYADLARMPVLDRVLKETLRLWPTAPAFAVAPFDDVVLGGRYRLRKD
RRISVVLTALHRDPKVWANPERFDIDRFLPENEAKLPAHAYMPFGQGERACIGRQFALTE
AKLALALMLRNFAFQDPHDYQFRLKETLTIKPDQFVLRVRRRRPHERFV
TRQASQAVADAAQTDVRGHGQAMTVLCASSLGTARELAEQIHAGAIAAGFDAKLADLDDA
VGVLPTSGLVVVVAATYNGRAPDSARKFEAMLDADDASGYRANGMRLALLGCGNSQWATY
QAFPRRVFDFFITAGAVPLLPRGEADGNGDFDQAAERWLAQLWQALQADGAGTGGLGVDV
QVRSMAAIRAETLPAGTQAFTVLSNDELVGDPSGLWDFSIEAPRTSTRDIRLQLPPGITY
RTGDHIAVWPQNDAQLVSELCERLDLDPDAQATISAPHGMGRGLPIDQALPVRQLLTHFI
ELQDVVSRQTLRALAQATRCPFTKQSIEQLASDDAEHGYA
CYP102F1 Actinosynnema pretiosum subsp. auranticum
AF453501 complement(6501..9518)
maytansinoid antitumor agent ansamitocin biosynthetic gene cluster I
49% to 102A3
gene = asm30
MVATGTRIPGPKPLPLVGNLLDVLTSDLDTDVDFLDRCHREHGG
IVALTFAGQRQVFASSHELVARMCSDPSWGKAVHPALEQVRDFAGDGLFTARGDEPNW
GKAHRLLMPAFGPTAMRDHFPAMLDIAEQMLVRWRRFGPDHRIDVADDMTRLTLDTIA
LCAFGARFNSFYRDRAHPFVDAMVRSLVEAGERAERLPGVQPFLVGRNQRYRDDIATM
NRIADGIVAARAALPAGERPDDLLERMLTCADPVTGERLSARNVRYQLATFLIAGHET
TSGLLSFAVHRLLAHPEVLRKAKDAVDGVLGDRVPAFEDLARLDYLGQVLRETLRLHP
TAPAFALAPDEPAELGGHAIGAGEPVLVMLPTLHRDPAVWRDPDVFDPERFAPERMDE
IPACAWMPFGHGARACIGRPFALQEATLVLALVLQRFDLALADPDHRLTIKQTLTLKP
DSLVVRARPRADRPGATATVETVVPHQVPATHRHGTPLHVFYGSNGGSGEGLARTIAG
DGAARGWATSVAPLDDAVRALPASGPVVIVSSSYNGAPPDNAAHFVRWLTQDGPDLSG
VDYLVLGCGNLDWSATYQRVPTLIDEAMAAAGARRLRERGATDARADFFGDWERWYEP
LWPLLSAECGVEVGEIGPRFRVVESDAADGLGDLASAVVLENRELVRGPDAGSKRHLE
LRLPDGTSYRTGDYLSVLPQNHPDLVRRAVARLGTRAERVVTVESSAPTGLVPVGRAL
RVDELLTRCVDLSAPAGAGVVARLAERCPCPPERAELAATTGATLLELLERFPSCAVD
LALALELLPAPRTRLYSISSAAEEQRAEVALTVSVTGVTSGYLSRVRPGDRVAVGIAS
PPESFRPPADNTVPVVLIAAGTGIAPFRGFLRARAALGGEPGPALLLFGCRGPELDDL
YAEEFAALGDWLEVDRAYSRHPDGEVRHVQHRLWQRRDRVRELVDAGARVYLCGDATR
VGPAVEEVLGRIGPGAGWLDALRAGGRYATDVF
CYP102G1 Streptomyces scabies
SCAB5931
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
52% to 102A5 Bacillus cereus P450 part
52% to 102A3 Bacillus subtilis, 45% to 102D1
CYP102G2 Saccharopolyspora erythraea NRRL23338
SACE_4205, 4676800,4679985 (-) STRAND
56% to CYP102G1 Streptomyces scabies, 51% to CYP102B2
MTQTPLHHDDVPVADVSGTGLTATPTQQAMELARRHGPVFRRRTREFQSLLVSDVDLVAE
LSDEQRFAKAVGPALENVREFAADGLFTAYNDEFNWAKAHDILMPAFALGSMRTYHPVML
RVARRLLDSWDRAAAASAPVDVPDDMTRMTLDTIGLAGFGFDFGSFGRAEPHPFVGAMVR
CLDWSMTRLSRVPGTDHSERDEAFRADARYLASVVDEVINTRAAEGDTSGEDLLGLMLGA
RHPADGTTLDAANIRNQIITFLIAGHETTSGTLSFALHYLAKNPTVLRLVQREADELWGD
SPDPEPSFEDIGRLTYTRQVLNETLRLWPSAPAFGRQARHDTVLGGRIPMRAGEAAAVLI
PMLHRSPVRGDNPELFDPARFAPEAEAARGPHAFKPFGTGERACIGRQFALDEATMVLAM
LAHRYRLVDHAGYRLKVKETLTLKPEGLTLAVRARTAADRVTNRLALPVGLPSAAPGEPA
DAARRPGRVLPGTGLLLLHGSNYGTCRDFAAQLALAAGELGCDTAVAPLDEYAGNLPSDR
PVIVVAASYNGRPTDDAVSFSRWLDEAEPGAADGVDFAVLGVGDRNWAATYQHVPTRIDA
RLAELGGTRILERGEADASGDLAGAVRRFSAALETALLERSGDPDAVAAAPEGDGPAYTV
SEVTGGALDSLAARHGMVEMTVTEVADLTAPDYPRTKRFVRLALPEGTAYRTADHLAVLP
VHDAALVERAAGVLGVDLDTVLDIRAKRPGRLTFDRSLTVRELLSHHVELQDPPTPDGLD
ALAALNPCPPERAALRGLAEEARSGTADHRTLWDLIEDHPALRDALSWSALLELLPATRP
RQYSVSSSPAVDPRHVDLMVSVLRAPARSGRGEFRGAGSRHLSEVRPGDTVLARVQPCRE
DFRVAPDEPLIMVAAGTGLAPFRGVIADRRERVANGARQAPALCYFGCDAPDADYLHSAE
LRAAESAGAVAMRPAFNEAPVGGQCFVQHRIAAEAGEVWALLESGARVLVCGDGRHMAPG
VREAFRGIYRERTPGADDASAHEWLQAMIAGGCYVEDVYAG
CYP102G3 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY587 67% to CYP102G2
CYP102H1 Nocardia farcinica IFM 10152 plasmid pNF1
GenEMBL AP006619 177679..179100
51% TO 102C1
MAVTTSTTSGGHSNPPLPHPKWRLPIINDLLTINPIKPTLTSLR
DAEQLGGIFERRLVDWPMIVVSDSELITEICDERNWAKHLGVPLRKMRHIARDGLFTA
RNDEPNWAKAHAVLAPAFTKEAMRSYHQTMLTTIGELLDYWAKRDGQWVDVGEDMNKL
TLEIIARTGFDYTFDSFTRSEVHPFVAAMLRGLTYISRNSNMPPFLQKTIGARAAARH
SRDITYVRTVVDDVIKARQASGTVGDHHDLLDRMLTVPDPASDELLDTTNVRSQILTM
LVAGHETSAGVLAFALYELSRRPELVAAARAEIETRFADGDLSTIAYDDVAKLRTLRR
IVDETLRLYPVAPGFFREARHETTIGGGRYRFGPGDWVLVLTLHAHRDPATWGPDAGE
FQPDRWLPERMRSLDGRQVFKPFGTGLRACIGRQFAYHEIVLALAHILHTFEFTPDPG
YELDIAEQITLKPHRFRLRLNHR
CYP102J1 Burkholderia sp. 383
ABB05850
50% to CYP102A4
1 MKSSSLVPQP PLKPVIGHLM EVLGPSPLAK MMDLARTYGP VYWFEVFGQG YYVVSGQTLV
61 DEVCDETRFQ KCVHQSLLEL RPAIGDGLFT AFGDEPNWAK AHRVLMQAFG PLSIWSMFDK
121 MVDIADQMFL HWERFGPETP VDVSDHMTRL TLDTIALCAF DCRFNSFYRE DQHPFVDAMV
181 NTLSEAGKRE LRPKLVSKLM VKRSRQFDAD IEVMRSLATK MIEDRRKNPH VNEESMDLLD
241 RMLNGIDPVT GEKLDDENIV FQMITFLIAG HETTSGLLSF ATYFLLKNPD ILQKARDMVD
301 EVVGSETPRI EHLARLRYVE QILMETLRIW PTAPGFAVKP LADTTFGGKY AVSPDDIIMI
361 LTPMLHRDVS VWGEDVEAFR PERFAPENAE QLPPNSWKPF GNGARACIGR PFAMQEAHLV
421 LIMLLQRFDF SFADPDYELD VAETLTLKPA GFRVNVKPRA RGALKVPDTA LHARSNAQSP
481 SVAPVQSIAP GEDLSNLLVL FGGNTGSAES FARRIAGDAS RHGFHATCAP LDDFAGKLGG
541 YPAIVIVTAS YEGQPPDNAK SFVPYVEALD EGALDGVHFS VLGCGNKQWA RTYQAIPKRV
601 DEALEKAGAT RVHFRGELDS GGDFFGEFDR WYTEMWNRFA ISAGKEIPVI QHDDVALKVS
661 FAGSSREKVL NLGDMAHASI VDNRELVDIS VAGSRSKKHI ELKLPEAMTY RSGDYLAVLP
721 RNAKNNVDRV LRRFRVSWDT QVVIEGTSSN PRLPLGQAIG CGELFSSYVE LAVPATRSQV
781 SSLAAATRCP PEKVELERLS ADGFECEILG KRTTVMDLLE RFGSVDLSLE KFLDMLPALK
841 ARQYSISSSP LWKADHVTLT VAVVDAPALS GNGRHEGVAS SYLARLNTGD SLSVAVRPSN
901 ARFRPPAEPD LPMILICAGS GIAPFRGFLQ ERALQKQRGE NVGTSLLFFG IDDPDVDFLY
961 RDELDEWARC GVVEVMPAYS NRPEEGARFV QDKVWLERER ISALFSQGAT VFVCGDGKNM
1021 APAVRATLGR IYQETTGEND ESASAWIDTM EREHGRYVAD VFA
CYP102K1 Azorhizobium caulinodans
AP009384.1 (protein BAF89518.1)
39% to CYP102F1 Actinosynnema pretiosum subsp. auranticum (P450 part)
39% to CYP102E1 Ralstonia metallidurans (P450 part)
top 31 blast hits are all CYP102 family members
103 Family
CYP103A1 Agrobacterium tumefaciens
GenEMBL M19352, AF242881 CDS 141158.142426
gene="virH1"
CYP103A2 Agrobacterium tumefaciens
GenEMBL AF034769
GenEMBL AB016260 CDS 124584..125759
CYP103A3 Agrobacterium tumefaciens plasmid pTiAB2/73 vir region
GenEMBL AF329849 892..2148
gene = virH
61% TO 103A1
MNARGPEKVSQTSGPIISASLDPDNVSVSDLDRSGHAIFAEWRP
KRPFLRRQDGVYVLLRADDVLGLSSDPRTRQIETELMLNRGINEGAVFDFVRYSMLFS
NNEVHSRRRSPFTRTFAFRMIENLRPQVSQLTETLFQDLKELDSFNFVEEFASKLPAV
AIAGLLGLPPSDIPYFTQLVYRVARCLSPSWRDADLPDIEASAAEFKNYVQAVIDDRR
SNPRDDFLSSFIRATREAEDLSPDEGLAQLMLIVLAGTDTTKTGLTALTGQLLRHRHV
WEALLKDESLVPAAVEEGLRFEPPVGSYPRLALADIDLEGFILPKGSLLALCTMSALR
DEKHFAHPELFDIHRKQMHWHMVFGAGAHRCLGEALARLELQEGLATVLRYAPTLSIE
GEWPTVQGHGGVRRIAEMRVGFRRQI
104 Family
CYP104A1 Agrobacterium tumefaciens
GenEMBL M19352, AF242881 CDS 142447..143670
gene="virH2"
CYP104A2 Agrobacterium tumefaciens
GenEMBL AB016260
103A2 CDS 124584..125759 and
104A2 CDS 125919..127094 83% to 104A1
105A Subfamily
CYP105A1 Streptomyces griseolus
GenEMBL M36480 (1629bp) Y18556 CDS 2447..3703
Omer,C.A., Lenstra,R., Litle,P.J., Dean,C.R., Tepperman,J.M.,
Leto,K.J., Romesser,J.A. and O'Keefe,D.P.
Genes for two herbicide-inducible cytochromes P-450 from
Streptomyces griseolus
J. Bacteriol. 172, 3335-3345 (1990)
Gene suaC
CYP105A2 Amycolata autotrophica
GenEMBL D26543 (1197bp)
Kawauchi,H., Sasaki,J., Adachi,T., Hanada,K., Beppu,T. and
Horinouchi,S.
Cloning and nucleotide sequence of a bacterial cytochrome P-450
VD25
gene encoding vitamin D-3 25-hydroxylase
Biochim. Biophys. Acta 1219, 179-183 (1994)
CYP105A3 Streptomyces carbophilus
GenEMBL D30815 PIR JC4287
Watanabe,I., Nara,F. and Serizawa,N.
Cloning, characterization and expression of the gene encoding
cytochrome P-450sca-2 from Streptomyces carbophilus involved in
production of pravastatin, a specific HMG-CoA reductase inhibitor
Gene 163 (1), 81-85 (1995)
105B Subfamily
CYP105B1 Streptomyces griseolus
GenEMBL M36481 (1688bp) M32239
Omer,C.A., Lenstra,R., Litle,P.J., Dean,C.R., Tepperman,J.M.,
Leto,K.J., Romesser,J.A. and O'Keefe,D.P.
Genes for two herbicide-inducible cytochromes P-450 from
Streptomyces griseolus
J. Bacteriol. 172, 3335-3345 (1990)
Gene subC, SU-2
CYP105B2 Streptomyces tubercidicus strain R-922
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Cyp229
78% to 105B1
CYP105B3 Saccharopolyspora erythraea NRRL23338
SACE_2842, se: 3099326,3100528 (+) STRAND
55% to CYP105B2, 54% to 105Q1, 53% to 105B1
MTSTLDESTPDYPMPRARGCPFDPPPALRDLQRETPMARVRLWDGSTPWLVTRYADQRAV
LRDSHVSADMNHPTYPRQAPGGGTLSFIGMDDPEHARLRRMVGSAFAVKNVERMRPWVQR
IVDEAVDELLAGPRPADLVEEFALPVPSLVICGLLDVPYADHAFFQSNSKTMINRDSTPE
QRSQASGRLAEYLSDLLSSKMDTRGDDLRSRLCGRIEAGDLTLRQATEMAVLLLIAGHET
TANMIALSTLLLLRHPDQLALLRESDDPDVARRAVEEMLRYLNITHGGRRRVALEDVEVA
GQRVRAGEGLVLPNEIANRDPDAFPDPDRLDITREARHHVAFGFGVHQCLGQPLARLELE
IVYRTLYRRAPRLALAAGIEDIPFKHDGFVYGVYELPVTW
CYP105B4 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7395
59% to CYP105B3 Saccharopolyspora erythraea NRRL23338
CYP105B5 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE9048 66% to CYP105B2
CYP105B6 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE1311 60% to CYP105B3
CYP105B7 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY920 64% to CYP105B3
CYP105B8 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2570 59% to CYP105B3
CYP105B9 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY7881 66% to CYP105B3
CYP105B10 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY8448 81% to CYP105B4
CYP105B11 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY8453 57% to CYP105B3
CYP105B12 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY8455 64% to CYP105B3
105C Subfamily
CYP105C1 Streptomyces sp.
GenEMBL M31939 PIR S19629 (381 amino acids)
Horii, M., Ishizaki, T., Paik, S.Y., Manome, T. and Murooka, Y.
An operon containing the genes for cholesterol oxidase and a
cytochrome P-450-like protein from a Streptomyces sp.
J. Bacteriol. 172, 3644-3653 (1990)
Gene choP
105D Subfamily
CYP105D1 Streptomyces griseus
GenEMBL S45823 X63601 (1700bp) PIR S24750 (412 amino acids)
Trower,M.K., Lenstra,R., Omer.C., Buchholz,S.E., and
Sariaslani,F.S.
Cloning, nucleotide sequence determination and expression
of the genes encoding cytochrome P-450soy (soyC) and
ferredoxinsoy (soyB) from streptomyces griseus.
Mol. Microbiol. 6, 2125-2134 (1992)
PIR S35901 (412 amino acids)
Erratum. Cloning, nucleotide sequence determination and
expression of the genes encoding cytochrome P-450(soy)
(soyC) and ferredoxin(soy) (soyB) from Streptomyces griseus.
Mol. Microbiol. 7, 1024-1025 (1993)
CYP105D2 Streptomyces griseus
GenEMBL AF071145
84% identical to 105D1 partial seq.
CYP105D2 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR264
One amino acid difference with partial sequence
This is a complete sequence
CYP105D3 Streptomyces sclerotialus
GenEMBL AF071149
68% identical to 105D1
CYP105D4 Streptomyces lividans
GenEMBL AF072709 CDS complement(1593..2813)
69% to 105D1 67% to 105D2 82% to 105D3 57% to 105A1
CYP105D5 Streptomyces coelicolor
3StF60 [Full Sequence] Sanger cosmid
CDS comp(2106-3344) 98% identical to CYP105D4
cloned and expressed by David Lamb and Steve Kelly
CYP105D6 Streptomyces avermitilis
GenEMBL AB070949.1 69121-70371
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV412_pteD 55% to 105D1 from Streptomyces griseus,
53% to 105D4, 54% to 105D5 (if first 17aa left off 105D5)
Gene = pteD
CYP105D7 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV7469 73% to 105D4 from Streptomyces lividans
CYP105D8 Streptomyces tubercidicus strain I-1529
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Cyp233
68% to 105D7
CYP105D9 Streptomyces sp. JP95
GenEMBL AF509565 11774..13024
griseorhodin biosynthesis gene cluster
55% to 105D6
gene = grhO3
MTDTLDEPQTLADGAEDAPAYPVKRTCPYRMPPGYEELREKGPI
SRVTLWNGRTAWLVTGNDLGRRLFPDARLSSDVLDPRFPLLAPRIEAQRQQAAAPPLV
GVDDPVHARQRRMVLPSFGIRQINALRPEIQKYADDLLDTMLAKGPGVTVDLLTEYAL
PMPSAVICMLLGVPYEDHHYFDERSRHVLSSSGEEQAAQAQQAFTEILAYLDDLIVRK
QAEPGDTLLDELIARQLEEGKVDRQELAMIATVLLVSGHETTSNMIALSTMALLADPD
QLAALRADESLMPRAVDELMRFSSIGDMLMRVAKEDIEIEGHLIRAGDGVILSTMLMN
RDPGAFERPDELDIRRPAGRHVAFGYGIHQCIGQNLARAEMEIALATLFRRVPTLKLA
VPAEQVPVNAPFVLQGVSELPVTW
105E Subfamily
CYP105E1 Rhodococcus fascians
GenEMBL Z29635 (7139bp) PIR S42052 (399 amino acids)
Crespi,M., Vereecke,D.M., Temmerman,W.G., Van Montagu,M.
and Desomer,J.
The fas operon of Rhodococcus fascians encodes new genes required
for efficient fasciation of host plants.
J. Bact. 176, 2492-2501 (1994)
MAGTADLPLEMRRNGLNPTEELAQVRDRDGVIPVGELYGAPAFL
VCRYEDVRRIFADSNRFSNAHTPMFAIPSGGDVIEDELAAMRAGNLIGLDPPDHTRLR
HILAAEFSVHRLSRLQPRIAEIVDSALDGLEQAGQPADLMDRYALPVSLLVLCELLGV
PYADRDELRDRTARLLDLSASAEQRAVAQREDRRYMATLVTRAQEQPGDDLLGILARK
IGDNLSTDELISIISLIMLGGHETTASMIGLSVLALLHHPEQAAMMIEDPNCVNSGIE
ELLRWLSVAHSQPPRMAVTEVQIAGVTIPAGSFVIPSLLAANRDSNLTDRPDDLDITR
GVAGHLAFGHGVHFCLGHSLARMTLRTAVPAVLRRFPDLALSPSHDVRLRSASIVLGL
EELQLTW
CYP105F1 Streptomyces lavendulae
GenEMBL AF127374 CDS 2006..3229
48% to 105C1 42% to 105B1 40% to 105D1 new subfamily in 105
CYP105F2 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
85% to 105F1
clone name SP8812
CYP105G1 Amycolatopsis mediterranei
GenEMBL AF040571 CDS complement(5011..6066)
49% to 105C1, 105B1 new subfamily in 105
looks like an insertion in the seq from 80-120
CYP105H1 Streptomyces noursei ATCC 11455 nyst
GenEMBL AF263912 CDS comp (58637..59833)
gene="nysN" 47% to 105B1 46% to 105A1 46% to 105D1
function="presumably involved in modification of the
nystatin macrolactone ring"
CYP105H2 Streptomyces albus
GenEMBL AF071143
77% to 105H1
LLIAGHETTANNIGLGVVTLLSHPQWAGDERAVEELLRLHSVAD
MVALRVAVDDVEIAGQVIRKGEGIVPLLAAANHDTEVFGCPHAFDPERSERRHVAFGY
GVHQCLGQNL
CYP105H3 Streptomyces natalensis
GenEMBL AJ278573 52789..53985
pimaricin biosynthetic gene cluster.
68% to 105H1
gene = pimG
MTYTDPAAPETDPPAVDFPQRKPGVPFPPPDYADYRDRKGLVLS
QLSDGKRVWLVTRHEDVRAVLTSPSISSNPEHKGFPNVGNLGVPKQDQIPGWFVGMDS
PEHDRFRKALIPEFTVRRVRAMKPAIERTVDAQLDAMLAAGNTADLVADFALPIPSLV
ISALLGVPPADREFFESRTRVLVSLRSSTDDDRMAAAKDLLRYINRLVEIKQKWGGDD
LITRLLATGAIAPHEMSGVLMLLLIAGHETTANNIALGVVTLLANPQWIGDDRAVEET
LRFHSVADLVSLRVAVQDVEIAGQLIKAGEGIVPLVAAANHDENAFECPHAFDPSRSA
RHHVAFGYGVHQCLGQNLVRIEMEVAYRKLFERIPNLELAVPTDGLDIKYDGVLYGLN
ELPVRW
CYP105H4 Streptomyces nodosus
GenEMBL AF357202 complement(62051..63250)
amphotericin biosynthetic gene cluster
84% to 105H1
MTAETEMTTFAPGCPVAFPLRRPGRPFPPPEYADYRAGEGLVRS
ELPASGPVWLVTRHEDVRTVLTDPRISADPSRPGFPRARRTGGAPSQSEIPGWFVALD
PPEHDRFRKTLIPEFTVRKVRELRPAIQQIVDERIDALLAAGNSADLIADFALSVPSL
VISDLLGVPKADRDFFEAKTKVLVTLSSTDEQRDEASKALLRYLNRLIQIKGRRPGED
LISRLLQAGTMNRQELSGVSMLLLIAGHETTANNIGLGVVQLLTNPQWIGDDRIVEEM
LRYYSVADLVSFRVAVEDVEIGGQLIKAGEGIVPLIAAANHDGSVFDKPEEFNPERSA
RSHVAFGYGVHQCLGQNLVRVEMEIAYRTLFERIPTLELAVPVEELPLKYDGVLFGLH
ELPVTWS
CYP105H5 Streptomyces griseus
GenEMBL AJ300302 10678..11859
Gene = canC
72% to 105H3
MTTSPGPTVVDFPRRTPREPLPLSQYAEHRKQNGLVQTHLPNGR
PIWLVTRHEDVRAVLTHPRISANPDNEGFPNVGETMGVPKQEQIPGWFVGLDSPEHDR
FRKVLIPEFTVRRVRELRPAIERTVDERIDAMLAGGNTADLVNDFALPVPSLVISALL
GVPSADRDFFESRTRTLVAIRTSTDEERAEATRQLLRYINRLIVIKKKWRGEDLISRL
LSTGKLSDEELSGVLLLLLIAGHETTANNIGLGVVTLLSHREWIGDDRLVEELLRLHS
VADMVALRVAVDDVEIAGQTIRKGEGIVPLLASANHDTEAFGCPHAFNPERTERRHVA
FGYGVHQCLGQNLVRVEMEIAYRKLFERIPELRLAVPEDQLAYKYDGILFGLHELPVR
W
CYP105H6 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_4165
67% to CYP105H4 Streptomyces nodosus
CYP105H7 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY1473 66% to CYP105H4
CYP105J1 Amycolatopsis mediterranei rifamycin
GenEMBL AF040570 CDS comp (67462..68673)
52% to AF072709 105D4 50% to 105D1 new subfamily in 105
CYP105K1 Streptomyces tendae strain Tue901
GenEMBL Y18574 CDS 6325..7557
45% to 105A3 46% to 105D1 43% to 105B1 new subfamily in 105
gene="nikF"
CYP105K2 Streptomyces ansochromogenes
GenEMBL AF469953 14..1246
95% to 105K1
note="involved in nikkomycin biosynthesis
MTEAFDHDIPSFPMARECPMHPPAEYRELRGQEPVSRVRMPDGQ
VAWLVLKHALARKLLADPRVSADRLHPAFPGRLTAEQRAATERVRRLTTRRSMIHLDG
DEHGAHRRILTGEFSLRRIAAQRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIQERAAASDALNDFLEALVTEKERGEPADD
LIGRLIARNRQTPVMTHDEIVGTAVMLLVAGHQTTANMISLGVVALLENPEHKARIAA
DSSLLPPAIEEMLRYFSVVENAPARVATEDIAIGGVTIRKNEGIVVSGLAADWDDEVF
GHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC
CYP105L1 Streptomyces fradiae
GenEMBL AF055922 CDS comp (6507..7769)
GenEMBL AF147703 complement(2565..3875)
Fouces,R., Mellado,E., Diez,B. and Barredo,J.L.
The left edge of the tylosin gene cluster from Streptomyces
fradiae
Microbiology (1999) In press
tylH1
46% to 105A1 42% to 105D1 43% to 105B1 new subfamily in 105
MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFS
PPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDG
EAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRDVRPSVEQIVTGLLDDLTARGDEAD
LLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRL
ISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL
QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLL
AAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA
LRPTTDVAGLRLKSDSAVFGVYELPVAW
CYP105L2 Micromonospora griseorubida
GenEMBL AB089954 1490..2641
gene cluster for the polyketide macrolide mycinamicin
54% to 105L1
gene = mycCI
MDRTCAWALPEQYAEFRQRATGWPAKVWDGSPTWLVSRYEHVRA
LLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMR
PEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELAS
RPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVL
LLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA
TADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLG
QNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW
CYP105M1 Streptomyces clavuligerus clavulanic
GenEMBL AF200819 CDS 136..1359
GenEMBL AY034175 CDS 200..1423
GenEMBL U87786 CDS 13810..15036
function="involved in clavulanic acid biosynthesis"
48% to 105B1 42% to 105A1 41% to 105D1 new subfamily in 105
MNEAAPQSDQVAPAYPMHRVCPVDPPPQLAGLRSQKAASRVTLW
DGSQVWLVTSHAGARAVLGDRRFTAVTSAPGFPMLTRTSQLVRANPESASFIRMDDPQ
HSRLRSMLTRDFLARRAEALRPAVRELLDEILGGLVKGERPVDLVAGLTIPVPSRVIT
LLFGAGDDRREFIEDRSAVLIDRGYTPEQVAKARDELDGYLRELVEERIENPGTDLIS
RLVIDQVRPGHLRVEEMVPMCRLLLVAGHGTTTSQASLSLLSLLTDPELAGRLTEDPA
LLPKAVEELLRFHSIVQNGLARAAVEDVQLDDVLIRAGEGVVLSLSAGNRDETVFPDP
DRVDVDRDARRHLAFGHGMHQCLGQWLARVELEEILAAVLRWMPGARLAVPFEELDFR
HEVSSYGLGALPVTW
CYP105N1 Streptomyces coelicolor
St4C2 [Full Sequence] Sanger cosmid
CDS 29986-31221 45% to 105A1 new subfamily in 105
cloned and expressed by David Lamb and Steve Kelly
CYP105N2 Streptomyces glaucescens cytochrome P450
GenEMBL AF071144
95% to 105N1 only 5 aa diffs
57% to AF071148 56% to AF071146 59% to 105D3 54% to 105A3
LLIAGHETTTSMIALSTLLLLDRPELPAELRNDPDLMPAAVDEL
LRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD
NHHVAFGYGMHQCLGQNL
CYP105N3 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
91% to 107N1
clone name SP0881
CYP105P1 Streptomyces avermitilis
GenEMBL AB070949.1 67376-68575
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV413_pteC low 40% range to 105 subfamilies
Gene = pteC
CYP105P2 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
92% to 105P1
clone name SP7863
CYP105Q1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV1611 49% to 105B1 from Streptomyces griseolus
46% to 105D4 and D5
CYP105Q2 Streptomyces sp.
GenEMBL BD133549
78% to CYP105Q1
3 LIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHSGLRRVA 182
183 KGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGFGTHQC 350
CYP105Q3 Streptomyces sp.
GenEMBL BD133546
77% to 105Q1
139 MADTLTDAAPDTDGRVPEYPMPRATGCPLAPSPAAAELRGDRPITRVRIWNGSTPWLITR 318
319 HADQRTLLTDPRVSNDDHEPDFPHVNAHRAAIAPHTPKLITNTDAPEHTRLRRSVNAPFL 498
499 VKRIEAMRPAVQKIVDDLIDDMLAGPSPADLLTALALPVPSLVIAELLGVPYEDHHFFQE 678
679 NSNRVLDNSLTAEEAQESSRALGGYLDTLFRTKLEQPGEDVLSEMGSKVKAGEMTHQEAV 858
859 SMGVAMLIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHS 1038
1039 GLRRVAKGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGYGPH 1218
1219 QCLGQNLARLELQVVYGTLYRRVLTLRPAVPVDQLAFNHTGTTYGVKCLPVTW 1377
CYP105Q4 Mycobacterium marinum
No accession number
Tim Stinear
MM4762
52% to 105Q1
CYP105Q4 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 105Q4 M. marinum = ortholog
CYP105Q5 Streptomyces scabies
SCAB11341
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
92% to 105Q3 Streptomyces sp.
CYP105Q6 Mycobacterium vanbaalenii PYR-1
ZP_01205830.1, EAS26822.1
50% to 105Q3, 86% to CYP105Q7
MTETLAQEAVSVPEYPMERTAGCPFAPPQQMLEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVS VDDRREGFPHWNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVIQQVTDECIDEILA GPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLHQYLINLVEEKQ AHPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLENPEQAALLRDSDDPKFI ANAVEELMRYLSIIQNGQRRVATEDIEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRDATQQLG FGYGRHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYGVYELPVTW
CYP105Q7 Mycobacterium smegmatis
MSMEG4843 TIGR
53% to CYP105Q1, 51% to 105Q3
86% to 105Q6 M. vanbaalenii, 76% to 105Q4 M. marinum
Formerly CYP105T1 but more similar to CYP105Q sequences
MSETLTQPSATDIPGYPMERAAACPFAPPPQMLDMNKAKGLSRVRIWDGS
TPWLITGHEEARALFADSRVSVDDRRPGFPHWNEHMLATVHKRPRSVFTS
DAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDECIDAILAGPQPADIVD
KLALPVPTVVISEMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLH
QYLIDLIEKKQAEPAEDAVSDLAERVTAGELSVKEAAQLGTGLLIAGHET
TANMIGIGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQR
RVAVEDIEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRDAGQQL
GFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLA
YGVYELPVAW
CYP105R1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV7186
CYP105S1 Mycobacterium smegmatis
MSMEG0758 TIGR
fas1
52% to 105E1
76% to 105S2 Mycobacterium vanbaalenii
MTQAQALPPLHIRRDAFDPTPELGEIRAGEGVHVTVNPFGMQVYLVTRHE
DVKTVLSDHERFSNSRPPGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQ
RLRRMLTPEFTIRRIKRLEPRIVEIVDAHLDAMESAGPPADIVADFALPI
PSLVICELLGVPYEDRTDFQQRSARQLDLSAPMPERLELQRQGRAYMRGL
VERSRTRPGDDILGMLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGL
GVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTTDVEL
AGVTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRRGAPGHLAFGHGVHHC
LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQSLAVAW
CYP105S2 Mycobacterium vanbaalenii PYR-1
ZP_01208508.1, EAS22074.1
52% to 105E1, 76% to CYP105S1
MSQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPP GFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARD GEASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGAR TNPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPA VEELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGH GVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW
CYP105S3 Frankia alni ACN14a
YP_713209.1
CAJ61641.1
62% to CYP105S1 Mycobacterium smegmatis
MRRAQFDPISELSTARDTVGVCPVVTPFGVPAHLVSRYDDVREVLSDSVRFSTADRHALMPPDAAGPTEQ
EYAQARVGNLLAYDPPEHTRLRRMLTPEFTMRRMRALEPRIVDIVSAALDDVERAGRPADLVSTFALPVP
SLVICELLGVPYADRAEFQRRTVDQLDASHPPEHRLALQQASRAYMATLVERARRDPGEDILGMLVREHG
DDISAEELVGIASLLLLAGHETTANMLGLGTLALLRHPDQLARVRDDPASVEPAVEELLRWLSIVHAGIP
RTATTEVTIAGSTIAAGEHVVLALPGANRDPALVDDPDRLDITREPAGHVAFGHGLHHCLGAPLARLELR
IAYPALLRRFPGLALAVPYEQIAFRPYSVIHGLQALPVTW
CYP105S4 Frankia sp. CcI3
YP_480704.1
ABD10975.1
75% to CAJ61641
65% to CYP105S1 Mycobacterium smegmatis
MAAAPIVPLHIRRAQFDPIEELVRIRDTDGVCRVVTVFGIPAYLVSRYEDVREILADPGRFSNVNQWVVG
PGGPVLSDEEIAELRAGQMLAFDPPDHTRLRRMLTPEFTVRRMRGLEPRIRDIVDAALDEVERAGRPADL
VATFALPVPSLVICELLGVPYSDRAEFQQRTRRQIDASLPIEQRLALQREARAYMAGLVTRAQAAPGEDL
LGMLVREHGDELSTAELVGIASLLLVAGHETTSNMLALGTLALLRHPDQLAMVRDDPAQVEPAVEELLRW
LSIVPSGVPRTTTTEVEIAGHRIPAGEQLLLALPAANRDPALVGDPDRLDITRGAPGHVAFGHGVHHCLG
APLARMEMRIAFPALLRRFPDLALAVPYEQVAFRAHHVVHGLHALPVTW
CYP105T1 Burkholderia fungorum
GenEMBL NZ_AAAJ02000095
8366..9610 gene = Bcep2217
44% to 105H1
MRKTMTSAINDVRPQTTSTFPFARTGSPLHPPAEYARYRDGQPV
TRVQMWDGRYAWIFTRMEDVKAVLSSPHFSVVPSKPGYPFLTPARAATVKSYQTFITM
DPPDHTRFRRMLTRDFTQKRMEELRPQIAAYVNRLIDEMLARGSPGDLVSALALKLPV
TVVSMLVGVPYEDHEDLVKWSGQRLDLEQNPTVSESAADNMLAYFDGLLQRKERDPGD
GADMLSRLVIEQIKPGHLSRLEAIHMVNLLYFAGHETTANQIALGTLSFLLDPRQRAL
LENNPGLLKNAIEEMLRFHTISHYNSCRVATADVEVGGTLIREGEGAYALIMAANRDP
AAFPAPDRFDIERPNSQEHVAFSYGLHMCLGQPLARLELQVCFEALFRRLPRLRLAVP
LEELPFKREMYVYGLHALPVTW
CYP105U1 Streptomyces hygroscopicus strain NRRL 3602
AY179507 complement(63940..65133)
Geldanamycin biosynthesis gene cluster
50% to 105B1 52% to 105B2 not 105S
gene = gdmP
MDEIRDYPESRAAACPFSPPLGYEELRERSAVTRVRMWDGSTPF
LVTGYHEARAALGDSRFSADGTHKAMPRFVKFEVPAEVFNLGRMDDPEHARIRRMLTA
NFTIRRTEAMRPMIQGIVDGLLDRLIAQGPPADLVADFAFPLPSQVIGVMLGVSDADF
AEFQQASQGVMDFTASAEEMGAALGVMVDYVARMCAAKRADPGDDLLSRLIVDQELTG
GLTQQQVVATALVLLLAGHETTANMIALSTVLLLSHPEQLARLRADAGLMGNAVDELL
RYITIVQEGTGRVATEDVEVGGVLIPGGEGVIINLPSANRDPHFADAHELDLSRPNAR
EHVAFGFGVHQCLGQTLARVELQIALETLLRRLPTLRLEVPFDDLAFLYESMNFGVAR
VPVAW
CYP105V1 Streptomyces sp. HK803
GenEMBL AY354515 36297..37508
Gene = plmT4
43% to CYP105Q1
MSQLSSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDG
KEVWLITGYDEIRSIFTDPRISVDNTQPGYPWLSEQARTVVLTGGVKPVGRMDPPEHT
AMRRMLGQGFLVKKIQNMRGDVEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWV
LGVPPADKRLISLVPRLFDEDSGLEGAMEARAELFAYIDELITHRENQPGDDIISHLV
GYYQKGELSRVSVLTQSVTLIAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPA
AVEELLRYTVVTEFSSKRVAAADIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLD
VRRDAKQHLGFGAGIHTCIGKQLARMELEVVYGTLFRRIPELRLAVPFDQLVFRNTFD
VQGVRALPVTW
CYP105W1 Micromonospora echinospora
GenEMBL AF497482 84045..85229
Gene = calE10
calicheamicin biosynthetic locus
45% to CYP105K1 47% to 105D4
MPRRCPFGPPAEYARLRTERPVARLPMLGGNTAWVVSRYADVKR
VLSDPRMSADRRRAGFPRFAPTTESQRQASFANFRPPLNWMDPPEHTAARRQIVDEFA
ARRVRQLRPLVERVVDEHLDAMTAGRSSADLVPSFSYPVPSRVICEMLGVPYGEHAFF
ERRSTRMLSRGVPADERARCAREIREFLDGVVTDKERHPGDDVLSRLLAAQRAAGEPD
HEAVVSMAFVLLVAGHVTTSNMISLSVLALLTHPERLARLRAEPDRFPAAVEELLRYF
TIVEAATARTATADVTVGGVTIRAGEGVVALGQAANRDPAAFDRPDEFDPDRDARHHL
AFGYGRHICPGQHLARLELDVALSRLVRRLPGLRLTVDVDDLPLKEDGNIFGLHALPVAW
CYP105X1 Pseudonocardia autotrophica same as Amycolata autotrophica
GenEMBL AF525299 2766..3974
Gene = pauC
P-450 gene cluster
49% to 105A3
MAEDTLGQDFPMQRQCPFEPPKEYERLRAEQPISRVRMPDGTPA
WLVTLHEDVRTVLASPAFSSDLAHPGMPAVNPEIRTIARQQRPPFSRMDPPEHSFFRR
MLIPEFTVKRTKTLRAGIQSVVDGLIDDLLRKSPPVDLVDEFALPVPSLVICQLLGVP
YSRHEFFQQQARVILSRQSTREQVGAAFTALRAYLDTLVEEKLHTPGDDLTSRLATEH
LEPTGDVRRQDLVASCMLLLTAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEA
VEELVRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDI
HRGNRRHACFGYGVHQCIGQHLARTELEVAFSTLFTRIPTLQIAAPSDELDYDHDGML
FGLHELPVTW
CYP105X2 Amycolata autotrophica same as Pseudonocardia autotrophica
GenEMBL AF071148
99% to 105X3 94% to 105X1 61% to 165B2
LLIAGHETTSHMISLGVTALLERPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL
CYP105X3 Micromonospora inyoensis
GenEMBL AF071146
99% to 105X2 61% to 165B2 60% to 105A3
LLIAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL
CYP105Y1X Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha04313
Submitted to nomenclature committee 12/13/04
Name changed to CYP105AA3
48% to CYP105X1, 46% to 105D7
CYP105Z1 Streptomyces scabies
SCAB17851
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
49% to 105B1 Streptomyces griseolus
51% to 105B2 Streptomyces tubercidicus possible ortholog
CYP105AA1 Streptomyces tubercidicus strain R-922
GenEMBL AY549204
Istvan Molnar, Syngenta Biotechnology, Inc.
Jungmann,V., Molnar,I., Hammer,P.E., Hill,D.S., Zirkle,R.,
Buckel,T.G., Buckel,D., Ligon,J.M. and Pachlatko,J.P.
Biocatalytic conversion of avermectin to 4'-oxo-avermectin:
characterization of biocatalytically active bacterial strains and
of cytochrome p450 monooxygenase enzymes and their genes
Appl. Environ. Microbiol. 71 (11), 6968-6976 (2005)
Submitted to nomenclature committee June 2, 2003
Clone name Cyp230
56% to CYP105AA2
formerly 105S1, but that name was already assigned to
a Mycobacterium smegmatis sequence (my error).
MTGRSACGSGARSAPSVRTPASPPVGPSAAPVTPVTPSQPLTLL
EKDCPMTAMQPTARTQPMERTCPFSPPEGYRTLREEDPITQVTFPDGAKGWLVSRYSD
VRAVLADPRFGANGQQPPLPGMFLTMDPPEHTRFRRLLTGQFTVRRMRKLAPAVEQIV
AERLAEMAAAEGPVDLVQAFALPVPSLVICELLGVPYADREEFQENSSRMLRLDASQE
QFEQAQMAMYERIHQLVVAKRAHPTDDILSGLVQSGVLTDEEVTGVGVLLLIAGHETT
ANMIALGTMCLLGHPGQLASLRADPELMDDAVEELLRYLTIVQYGLRRMALEDVELGG
QRIKAGSVVVAALPSGNRDATHFSGDPETLDVRRPYSPHLAFGHGVHQCIGQQLARVE
MKAALSALIDRFPGLRLAVPAREVPMRDDMLIYGVHELPVTW
CYP105AA2 Streptomyces tubercidicus strain I-1529
GenEMBL AY549201, GenPept AAT45294
Istvan Molnar, Syngenta Biotechnology, Inc.
Jungmann,V., Molnar,I., Hammer,P.E., Hill,D.S., Zirkle,R.,
Buckel,T.G., Buckel,D., Ligon,J.M. and Pachlatko,J.P.
Biocatalytic conversion of avermectin to 4'-oxo-avermectin:
characterization of biocatalytically active bacterial strains and
of cytochrome p450 monooxygenase enzymes and their genes
Appl. Environ. Microbiol. 71 (11), 6968-6976 (2005)
Submitted to nomenclature committee June 2, 2003
Clone name Cyp234
56% to CYP105AA1
formerly 105S2, but that subfamily was already assigned to
a Mycobacterium smegmatis sequence (my error).
1 MTRTVPGPQA LPTERDAGPF APPRDISRMR EARPVSPMVF PDGHEGWIVT GYDAVRRLMA
61 DTRFSSRQDI GILHVPYETP GMPAPTEPSP QIPGLFIAMD PPDHTRLRRK LTGAFTVKRM
121 KQLEEHISDI VERQLDELTR LAPPVDLVKE FALPVPSLVI CALLGVPYAD RETFQVNSAK
181 FLEKDVSLDE KMAAYTGLTT YLSELVTRKR AAPGEDILSD LARHDDLTIE ELTGMAFLLL
241 LAGHETTANM LALGTFALLE HPEQLAELRA DPDLMPGAVE ELLRYLSIAD IFYRYATEDI
301 ELGGETIGKG STVVVSLLAA NHDPQRFDNP DTLDIHRTAR GHLSFGHGIH QCLGQQLARI
361 EMRAGFEGLL RRFPTLELAI PADEVKLKTD MNIYGVHELP VTWTDTAR
CYP105AA3 Rhodococcus jostii RHA1
YP_702567
Marianna A. Patrauchan
Rha04313
Submitted to nomenclature committee 12/13/04
Formerly CYP105Y1
84% to CYP105AA2, 48% to CYP105X1, 46% to 105D7
1 MSKTVAVPYG LPMERDAGPF DPPRRITRLR ETRPVSPMVF PDGHEGWLVT GYDAVRQLMA
61 DTRFSSRQDI GILHVPYETP GMPAATEPSP QMPGVFIAMD PPDHTRMRRK LAGAFTVKRM
121 KQLEDHIIDV AERQLDAMAR LTPPVDLVKE FALPVPSLVI CELLGVPYAD RDNFQVNSAK
181 FLIKDQPLDD KMAAYGALST YLADLVTRKR AAPGDDILSD LARDDDLTIE ELTGAAFLLL
241 LAGHETTANM LALGAFALLE NPEQLTELRT DPDLLPDAVE ELLRYLSVAD IFYRYATEDI
301 ELGGETIRAG STVVVSLLAA NRDPQRFDNP DTLDIRRKAR GHLSLGHGVH LCLGQQLARL
361 EMRAGFEGLL RRFPTLGLAI PAGDVKLRTD MNIYGVHELP VTWTETSR
CYP105AA4 Amycolatopsis azurea
GenPept BAD91667
80% to CYP105AA2
1 MTETVPVPQG LPMQRDAGPF APPSEITRLR GARPVSPMVF PDGHEGWLVT GYDEVRQMMA
61 DTRFSSRQDL GILHLPYETP GMPAPTEPSP PMPGMFVAMV PPDHGRLRKR LTGAFTVKRM
121 KQLEEHIVEI TEQHLDAMTK LVPPVDLVKE FALPVPSLVI CELLGVPYED RENFQANSAQ
181 LMVRDQTLEE KMAAFIGMNT FLTELVTRKR ETPGDDILSD LGRYDDLTIE ELAGAAFLLL
241 LAGHETTANM LALGTFALLE HPEQLAELRA DAELLPAAVE ELLRYLSVAD IFFRYATEDL
301 ELGGETIRAG STVIVSLLAA NRDPRRFENP DTLDLHRNAR GLLSFGHGVH QCLGQQLSRI
361 EMRAGFEGLL RRFPTLSLAV PADEVKLKTD MNIYGVHELP VTW
CYP105AA5 Streptomyces lydicus
GenPept BAG50414.1
79% to CYP105AA4
1 MSRTVPVPQG LPMERDAGPF DPPRDLTRLR EARPVSPLLF PDGHEGWLVT GYEAVRRLMA
61 DTRFSSRQDI GVLHVPYETP GMPVATEPSP QVPGLFIAMD PPDHTRLRRR LTGAFTVKRM
121 KMLEEHIHDI VERQLDAMAR LAPPVDLVKE FALPVPSLVI CEMLGVPYED RETFQVNSAK
181 FLVKDQPLDE KMAAYGALTT YLAELVTRKR ATPGEDILSD LARQDDLTVE ELTGIAFLLL
241 LAGHETTANM LALGTFALLE HPGQLAELRA HPELLPGAVE ELMRYLSVAD IFYRYATEDI
301 ELGGETIGKG STVVVSLLAA NRDPLRFDNP DALDVRRAAR GHLSFGHGVH QCLGQQLARI
361 EMRAGFDGLL RRFPTLELAL PADEVRLRTD MNIYGVHELP VTW
CYP105AA6 Rhodococcus opacus B4
GenPept BAH51173.1
78% to CYP105AA4
1 MTVKQTHTVS VPHGLPMERD AGPFDPPGDI TRLRDARPVS PLIFPDGHEG WLVTGYDAVR
61 QLLADTRFSS RSDLGIVHVP YETPGMPAAT EPSPQVPGLF IAMDPPDHTR LRRKLTGAFT
121 VRRMKQLEEH IADIVERQLD EMARLTPPVD LVQEFALPVP SLVICELLGV PYADRDTFQV
181 NTAKFLVKDQ ALDEKMAAYG ALTTYLAELV ALKRVTPGED ILSDLARDDD LTIEELIGIA
241 FLLLLAGHET TANMLALGAF ALLEHPEQLA ELRADPELMP NAVEELMRYL AVADIFYRYA
301 TEDIELGGET IGQGSTVVVS LLAANRDPRH FDNPDTLDLH RKARGHLSFG HGVHLCLGQQ
361 LARLEMRAGF AGLLRRFPAL ELAVPAGEVK LKTDMNIYGV HSLPVCLQPV STY
CYP105AA7 Actinosynnema mirum DSM 43827
GenPept EEH76286.1
69% to CYP105AA4
1 MDLTSPIPIP DGLPQERDAG PFAPTTFVAD LRARRPVCPL VFPDGHVGWL VTGHAAVRQV
61 LADTRFSSRL DLGVLHVPHP TPGMPQATEP SPQVPGLFVA MDPPDHTRLR RKLTGAFTVK
121 RMRALEERVA QVVEERLTAM AALTPPVDLV REFALPVPSL VICELLGVPY ADREVFQANT
181 ARFLVKDVEL AEKAAAYGAL TGYLAGLVAS KRAEPGEDVL SDLARHEDLT VEELTGCAFL
241 LLLAGHETTA NMVALGTFAL LEHPDQLAAL RAEPGLLGGA VEELTRYLSV GDLFYRYATE
301 DLELHGELIP AGSTVVLSLL AANHDPEAFE DAGALDVRRD ARGLVAFGHG VHQCLGQQLA
361 RVEMRAGFAG LLRRFPDLAL AVPAGEVPLK TDMNVYGVHA LPVTWGTAAG
CYP105AA8 Actinoplanes sp. ATCC 53771
No accession
Jamie Prior
Submitted to nomenclature committee April 28, 2009
93% to CYP105AA4, 81% to CYP105AA2
CYP105AA9 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2260 85% to CYP105AA2
CYP105AB1 Saccharopolyspora erythraea NRRL23338
SACE_3429, se: 3784062,3785189 (+) STRAND,
52% to CYP105W1, 51% to 105K1
LRSQEPVKRVRTIGGGTAWLVTRHEDVRRVLSDPRMSSDRTMPGFPSLVPGRRAIVAENK
QAMIGMDGQEHAEARRAVIGEFTVRRINRMRPRIQEIVDECVDRMLAAGGPVDLVRELSL
PVPSLVICELLGVPYSDHDFFQSRSALMISRSTPPERRRDVVLELRRYLDELVAEKVREP
ADDLLGRQVAQQSEKGEVDREGLVSLAFLLLIAGHETTANMISLGTLALLDNPDQLARIT
EDPARTPAAVEELLRYFSIVDGATSRTALADIEIGGVLIREGEGVVAVGLSANRDPEAFD
SPDELDLDRQARNHVAFGFGAHQCLGQNLARVELQIVFDTLFRRIPGLRLADGLDGIRFK
DDALVYGAHEMSVTW
CYP105AB2 Salinispora tropica (marine actinomycete)
Strop_1339 complement(1505346..1506596)
57% TO CYP105AB1 Saccharopolyspora erythraea
48% to CYP105K1 Y18574.1 Streptomyces tendae
MTETASIATTRTASGQLTDAEFPVQRGCPFTTPTEYEQIREESSIAKVRLKNGGEAWWIA
GHELGRSVLADRRFSSDRRRDNFPFVSTDPETRAQLQSQPTSMLGMDGAEHAQTRRALMG
EFTVRRMAGLRPRIQQIVDQHIDEMLATPQRSVDLVEALSLPVPSLVICELLGVPYADHD
FFQGLTGPLLRHTTPPEVRLRIQEELNTYLGTLIDRKLTDPTDDLLSRQIAKHRDNGTFD
RASMVSLAFLLLVAGHETTANMISLGVVGLLQHPDQLVIIKDDPDKTPLAVEELLRYFTI
ADSVTARVATEDVQLGDTTINAGDGVVISGLAADRDPTVFAEPDRLDLERGARHHVAFGF
GPHQCIGQTLARMELRIVFDTLFHRIPTLRLAAPLDDIPFKSDAFVYGIEELPVAW
CYP105AB3 Nonomuraea recticatena
AB180844
Gene name moxA
64% to CYP105AB2 Salinispora tropica (marine actinomycete)
MTKNVADELAGLELPVERGCPFAPPAAYERLRERAPINKVRLTS
GGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAE
HSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVI
CELLGVPYTDHDFFQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFS
RQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPG
RTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDP
AVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFK
GDSVIYGVHELPVTW
CYP105AC1 Saccharopolyspora erythraea NRRL23338
SACE_4243, se: 4724009,4725226 (-) STRAND,
52% to CYP105AA2, 52% to CYP105AA1
MQKHAPHNADDVLESLPRDRPSGCPFDPPEGLAEIRGQRPLTRLVYGDGHVGWLATGHAV
VRAVLADRRFSSRYELMHFPVAMPGLPAQIPPAQVGDITGIDPPEHTRYRKLLTGKFTVR
RMRALTERVEQITAERLDAMQRLGPPVDLVEAYAQPIPALMICELLGVPYDRLEEFLGLV
AASGDRDLTPEEQFDAFAKIQEFVRELVPAKRAKPTDDLLSDLTTTELTDQELAGIGGLL
LAAGLDTTANILALGTFALLRNPEQIAALREGDADRAVEELLRYLSIAHTGMRSALEDVE
IDGTLIRAGETVTLSIQAANRDPRRFTDPDALDLRRHAAGHLSFGHGIHQCLGQQLARVE
MRVAFPALFNRFPGLRLAVAPEEVPLRGDMNIYGVHGLPVTWDGA
CYP105AD1 Frankia alni ACN14a
YP_714282.1
CAJ62727.1
46% to CYP105AF1 YP_001507778 EAN1pec
47% to CYP105A1 Streptomyces griseolus
MTQAPQYPQTRTCPYEPPPAYKEIGQEGPVVKVSLFDGRESWMVTGYRESREILTHPNLSSLRTHPNFPI
VAPRFRSPVARSLALLAMDPPIHDVYRRYLNPHFSLRSVRAMRPELERIIAGYVDRIIDHGPPADLIEML
AVPMPSLIICHHLGVPYADHDFFQDCSGKVMLAGEEEAGKAAQDLVEYLDNLVTEQQRNPTDGLIGQLVR
ERVSDGDIGHDELVSIALVLLIAAHETTASTLAIGIINLLGHPEELAKLRADISLLPGAIEELLRYVATT
DLVAVRIAKGDIEIAGHHIREGEPVLVSGTLANRDPQVHQRADEFDIQRDDTFHLTFGFGIHQCLGQNLA
RLEIELALRELITRLPGLRLAVPMEELPILSAGTVQRVLELPVEW
CYP105AE1 Frankia alni ACN14a
YP_714292.1
CAJ62738.1
48% to YP_001507783 EAN1pec
52% to CYP105A3 Streptomyces carbophilus
MNRVTLFDGATAWLVTGHSHSRRLLADPRVSADRSRPDFPVVLPRFEADVFKPLAIIGFDPPQHGLQRGL
LTADFSMRSVRAKRESIERLVESLADRMLAAGPPADLVLDYSLPIPSMVVADLLGVPYADHQFFEDATVR
LLQATTPQGAEAAGEELLNYLDEQIRLRERDPDDTLLSRLGEHVHDEGLGRDIINKIALALLVGGHDTTS
QMIALGVVTLLDHPDQLAILRSDPSALPGVVEELLRMVSVTDLAGVRVATEDVEIDGQVIARGEGLIFCN
SMANRDPAVYDAPYEFDVRRSADDPPATRRHLTFGHGPHQCIGRNLARMELEIAYRVLFEKIPNLRLAVP
RDELPMRHGSTMQGVHRLPVTW
CYP105AF1 Frankia sp. EAN1pec
YP_001507778.1
ABW12872.1
56% to CYP105D8 Streptomyces tubercidicus
MSSNQAVVATPPAFPMDRGCPYHPPAGYAQLQQDGPITRATLFDGREVWVVTGYEEARRLLVDPRLSSDR
SRPDFPVLVPRMAAAKLVALVGMDPPEHDIQRRMLIGSFTVRRANALRPDIERIVGGRVDALLAHEPGEV
VDLVPEFALPIPSTVICELLGVPYGDHEFFEEQTRRMVIATSTAAEAAAASRALVDYFDELIARKRERPG
EGLLDELIAERLVTGQIGQDDLASMAMFLLVAGHETTANMLGLSVLALLEHPDQRARLIEDPAGRAAGAT
EELLRFLSVADEIQRIAAADIEVAGVVIRAGDGVYLPTAAANRTAATFPDPDALDIGRVPRGHLAFGYGI
HQCIGQNLARVELEIGLRELFGRIPTLRLAEPVEALGAKPGGSVQGVYRLPVVW
CYP105AF2 Frankia sp. EAN1pec
YP_001507783.1
ABW12877.1
54% to CYP105D8 Streptomyces tubercidicus
MTGTEIPEYPLARTCPFHPPAGYARYREHGPVNPVRLYDGRRVWAVTGHAEAREVLLNTRLFSSERADPR
YPATSPRFEAARKVRNFIGMDPPDHTAQRRMLQSSFTMRRINGLRPGIQRLVDELLDAIVAKGPVVDLVP
EFALPIPSIVISELLGVPYGDHAFFEQQSRRVASGTSTLEESADAFTQLLQYLDGLIQDKERSAGDGLLD
VLIAEQVRPGVLTRRELVDISLLLLVAGHETTASAIALGVVALLEHPDQLAALRADPALLPSAVEELLRF
TTIADSVARFATADTELAGQPVAAGDGVLVVLSAANRDGTVFPDPDLLDLARRARSHVAFGHGAHQCIGH
NIARAELEIAFSTLFARLPGLRLAVPLDRLPGKDAGGVQGVFELPVAW
CYP105AG1 Frankia alni ACN14a
YP_714209.1
CAJ62654.1
41% to CYP105Q1 Streptomyces avermitilis
MTTRHLIDQPISRDLAHPLDPPAAYTELRENQPVVRARFPNGSTGWLVTRFEEGSQVFSDPRFSAKRRRH
DTPEGEQAEAGDDAPFDAGFVMMDEPDHGVYRRLLTARFTPKAVQTRLQPYLDRIVAEHLDAIAAGPETF
DFVQALSLPIPCLVICELLGVPYADRDGFHHATEVMMDTGVSRAERDRGAHWLVDYITALVADKRRTGDT
EGILAELIGKADDEGSILSERQLVGLGVLLLFAGHDTTAAMMGLSTLTLLTHPEQRRDLTEHPERIGTAV
EELMRYLTIVQFGLGRVAAQDVELGGAHIGRGELVVVAMNAANRDPRVFADPDALDLDRTMVRHLGFGYG
VHACLGQNVARAELRTVLPALFRRFPHLRLATPPNEVPMDFTGTNYGVRKLMVTR
CYP105AH1 Frankia sp. EAN1pec
YP_001510028.1
ABW15122.1
46% to CYP105R1 Streptomyces avermitilis
MRELPPCAVRIPAGAADSRLAWLVTRYPDARQALMDPRLSADETLPGAPVRIQVPPDQKPGSFLRMDDPE
HARLRGTITTEFTARRVRGLRPAVQRLIDELLDGLAAGPRPTDLQDAFSRTLPTLVIARVLGVPDADSPF
FVEKTRVTISQGDTARSYAAYQEMSEYLGVLATRKQKEPADDLMSRLAVNHLATGKITLDELVGIARLVL
VAGHETTTNQIALNILSMLLDDDLRRTVLADDGVRIPQFVEESMRYWSISQDAIVRLAVEDFELGGTTMH
KGDAVVISIPAGNHDESMFPDPDRIDLDRDSGDHLQWGVGPHYCQGAPLARLEMELALKTLFGRFPGLRL
ATDDPDSVFRTGTVFHGVRELPVTW
CYP105AJ1 Frankia sp. CcI3
YP_480220.1
ABD10491.1
47% to CAJ61641
50% to CYP166B1 Streptomyces peucetius (probable 105 subfamily)
47% to CYP105AA2 Streptomyces tubercidicus
MQNAHSDLRMSSRGDLLRSPIPLPMAGERTEPAPGMFTAMDPPEHTRYRRHIVEWFSTRRTRSLEPRVIE
IVDQHLDAMIAGGGPADLVSAFAEPVSALVICELLGVPVEQREVFGAAIAALFTVHSSAEEAISGWQNIG
GLLMGLIQAKRVASADDLLGTLVARGELSDEELMTIGSVLLVAGHDTSTNMIAMGTFALLEHPEQYAALA
ADPGLAPGAVEELLRYLTIVHAGSIRAVSADLEFDGHQLTAGDAVSLSLAAANRDPALCDAPDRLDITRE
PVPHLAFGHGIHQCVGQQLSRLELRIAFESLARRLPNLHVAVPTSEIRTRSEMIIYGVRELPVTW
CYP105AK1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_6930
47% to CYP105S3
CYP105AK2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY4171 85% to CYP105AK1
CYP105AL1P Frankia alni ACN14a
YP_710901.1
CAJ59294.1
42% to CYP105AB1 Saccharopolyspora erythraea
MEAPLMTLSVESHLPSCPMERSSPFEPPPGYARARSEAPITKVRLVDGSTGWFVTGHALVRRLLNDPKVS
KNGLRPGYPPLVPDQEALVRGQKGFLVWMDPPDHTMYRRMLAGEFSVNTLERLRPHVEHIVNECIDQLLD
AGPPADLVQVLSLPVPTMTICELLGVPYTDRQLFQESTAATVNLRTTQEERNRTVAELRQCATRAGDRLP
HALPAAPGPARRAADALGADRLRAGRGRTGEDGLVVLLTEDPPEERRQEVIDAAGSCPAQAILVDGE
CYP105AM1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE8684 52% to CYP105AA1
CYP105AN1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE7349 51% to CYP105AA2
CYP105AN2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY589 68% to CYP105AN1
CYP105AP1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE9554 50% to CYP105B2
CYP105AQ1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY628
CYP105AR1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2321
CYP105AS1 Amycolatopsis orientalis
No accession number
Kirsty McLean
Submitted to nomenclature committee Dec. 5, 2012
53% to CYP105AA2 Streptomyces tubercidicus
CYP105 fragment Streptoalloteichus hindustanus
AF071147
66% to 105AA2, 63% to 105Y1
61% to 105C1 59% to AF040570 CDS 2652..3842 (CYP166A1)
LLIAGHETTANMLALGAFALLEHPEQLAELRANPDLMPGAVEEL
MRYLSIVHIGPVRTAVADVEIEGQLIRAGESVTVSVPAANWDPAKFPEPERLDLTRRT
SGHLAFGHGVHQCLRQNL
106 Family
CYP106A1 Bacillus megaterium
GenEMBL X16610
Gene BM-1
CYP106A2 Bacillus megaterium
GenEMBL Z21972 (4317bp) PIR S32216 (410 amino acids)
PIR S39924 (410 amino acids) Swiss Q06069 (410 amino acids)
Rauschenbach,R., Isernhagen,M., Noeske-Jungblut,C., Boidol,W.
and Siewert,G.
Cloning, sequencing and expression of the genes for cytochrome
P450meg, the steroid-15beta-monooxygenase from Bacillus
megaterium ATCC 13368.
Molec. Gen. Genet. 241, 170-176 (1993)
CYP106B1 Bacillus anthracis str. Ames
Genpept AAP26480
47% to 106A2 47% to 109B1
1 MASPENVILV HEISKLKTKE ELWNPYEWYQ FMRDNHPVHY DDEQDVWNVF LYDDVNRVLS
61 DYSLFSSRRE RRQFAIPPLE TRININSTDP PEHRNVRSIV SKAFTPRSLE QWKPRIQSIA
121 NELVKDIENC SEVDIVEQFA APLPVTVISD LLGVPTTDRK KIKAWSDILF MPYSKEKFND
181 LDAEKGIALN EFKAYLLPIV QEKRYHLTDD IISDLIRAEY EGERLTDEEI VTFSLGLLAA
241 GNETTTNLII NSFYCFLVDS PATYKEVREK PKLISKAVEE VLRYRFPVTL ARRITEDTNI
301 FGPLMKKDQM VVAWVSAANL DEKKFSQASK FNIHRIGNEK HLTFGKGPHF CLGAPLARLE
361 AEIALTTFIN AFEKIALSPS FNIEQCILEN EQTLKFLPIR LKPQ
CYP106B2P Bacillus cereus ATCC 14579
GenPept AAP09572 GenEMBL AE017006
83% to 106B1 54% to CYP109B1 YjiB Z99110 Bacillus subtilis I -helix
1 MTSVITDGEI VTFSLGLLAA GNETTTNLII NSFYCFLVDS PGIYEELRKE PNLILKAIEE
61 VLRYRFPVTL TRRITALSER ESPSPLGMG
CYP106B3P Bacillus cereus ATCC 14579
GenPept AAP09575 GenEMBL AE017006
87% to 106B1 54% to 106A2 C-term fragment
LKEDTNIFGPF
1 MKKNQMIVAW VSAANLDEKK FSQASQFNVH RTGNEKHLTF GKGPHFCLGA PLARLEAEIA
61 LTTFINAFEK IELFPSFCLE KCILENEQTL KYLPIRLKAT
107A Subfamily
CYP107A1 Saccharopolyspora erythraea
GenEMBL X60379 Swiss Q00441 (406 amino acids)
Haydock S.F., Dowson J.A., Dhillon N., Roberts G.A., Cortes J.,
Leadlay P.F.
Cloning and sequence analysis of genes involved in erythromycin
biosynthesis in Saccharopolyspora erythraea: sequence similarities
between eryG and a family of S-adenosylmethionine-dependent
methyltransferases.
Mol. Gen. Genet. 230, 120-128 (1991).
Weber J.M., Leung J.O., Swanson S.J., Idler K.B., Mcalpine J.B.
An erythromycin derivative produced by targeted gene disruption in
Saccharopolyspora erythraea.
Science 252, 114-117 (1991)
CYP107A1 Saccharopolyspora erythraea NRRL23338
SACE_0730, 825267,826481 (-) strand
EryF 6-deoxyerythronolide B hydroxylase (6-DEB hydroxylase)
MTTVPDLESDSFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTG
YDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLR
KLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELLGVD
EKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRV
QDDDDGRLSADELTSIALVLLLAGFEASVSLIGIGTYLLLTHPDQLALVRRDPSAL
PNAVEEILRYIAPPETTTRFAAEEVEIRGVAIPQYSTVLVANGAANRDPKQFPDPHRF
DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSL
LLRGIDHLPVRLDG
CYP107A2 Streptomyces rochei plasmid pSLA2-L
NC_004808 complement(44847..46067)
AB088224.1 complement(44847..46067)
64% to 107A1
note="ORF26 (406 aa), lankamycin biosynthesis protein
similar to M54983-1 Saccharopolyspora erythraea
6-deoxyerythronolide B hydroxylase, EryF CYP107A1
MTTDAHTAVPSLDSDLFHIDQYEAYAALREREPVSKVSFIGREA
FLITRHAEAKAALGDLRLSNDFKKQPPGVELPTYHGIPEDVRPYFANNMGSNDPPAHT
RLRRLVSREFTARRVESMRTRVAQLAEHLLDGLAGERETDLVERFAYPLPITVISELL
GVEERYQGDFGRWSNEFLVIDADRVEQREHAARALVGFILELVDRRRADPGSDLLSAL
IHVHDEDEDRLSTDELASVVLILLIAGFETSVSLIAMATYLLLTHPGELAKVRADPSL
VPNAVDEVLRFLGPAEITTRGTLEPVEIGGVHIPAHSTVLIAGAAANRDPRRFPDPER
FDVTRDTGGHLSFGHGIHFCVGGPLARLEGEIALRALLNRFPGLDLAIPAEQVRWRRS
FLRGIESLPVRLGR
107B Subfamily
CYP107B1 Saccharopolyspora erythraea
GenEMBL M83110 Swiss P33271 (405 amino acids) PIR B42606 (405
amino acids)
Andersen J.F., Hutchinson C.R.
Characterization of Saccharopolyspora erythraea cytochrome P-450
genes
and enzymes, including 6-deoxyerythronolide B hydroxylase.
J. Bacteriol. 174, 725-735 (1992)
CYP107B1 Saccharopolyspora erythraea NRRL23338
SACE_5814, se: 6524921,6526138 (-) STRAND
MTTGEVPDLLAFDDAFAQDRHNRYARMREEPVQRIRTVNGLDAWLITRYEDVKQALLDPR
IAKDFGRTQQIIEKRLADAERRPGFSPDLGPHMLNTDPPDHTRLRKLVVKAFTARRVEGL
RPRIEQITDDLLDRLAGRSEVDLIDEFAFPLPITVISELMGVEDSRRDDFRSWTNVLVDG
SQPEAQAQASVAMVEYLTELIAKKRTEPGDDLLTALLEAVEDGDRLSEGELIAMVFLLLV
AGHETTVNLIGNCVLSLLGNPDQLAALRNDPSLLPGAIEETLRYESPVANGTFRHTAEAV
RFGDVVIPEGELVWVALGAANRDGERFEDPDRFDITRETTGHVAFGHGIHFCVGAALARL
EAQIAVGRLLERFPDLRMAASPDDLRWRFSVLMRGLEKLPVRPGA
CYP107B2 Streptomyces sp.
GenEMBL BD133548
58% to 107B1
3 LIAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDSPVGIATFRFSTE 182
183 ALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFGFGMHHC 344
107C Subfamily
CYP107C1 Streptomyces thermotolerans
GenEMBL D30759 (3267bp complete sequence of CarA)
Arisawa,A., Kawamura,N., Takeda,K., Tsunekawa,N.,
Okamura,K. and Okamoto,R.
Cloning of a macrolide antibiotic biosynthesis gene acyA, which
encodes 3-O-acyltransferase, from Streptomyces thermotolerans and
its use for direct fermentative production of a hybrid macrolide.
Appl. Environ. Microbiol. 60, 2657-2660 (1994)
Arisawa,A., Tsunekawa,N., Okamura,K. and Okamoto,R.
Nucleotide sequence analysis of carbomycin biosynthetic genes
including macrolide antibiotics 3-O-acyltransferase gene from
Streptomyces thermotolerans.
unpublished (1994)
CYP107C1 Streptomyces thermotolerans
GenEMBL M80346 (2393bp C-terminal fragment of CarA)
Schoner,B.E., Geistlich,M., Rosteck,P., Rao.R.N., Seno,E.,
Reynolds,P., Cox,K., Burgett,S. and Hershberger,C.L.
Sequence similarity between macrolide resistance determinants and
ATP binding transport proteins.
Gene 115, 93-96 (1992)
Note: P450 fragment called carX. is equivalent to C-terminal of CarA.
107D Subfamily
CYP107D1 Streptomyces antibioticus
GenEMBL L37200 (1400bp)
Rodriguez,A.M., Olano,C., Mendez,C., Hutchinson,C.R. and
Salas,J.A.
A cytochrome P450-like gene possibly involved in oleandomycin
biosynthesis by Streptomycese antibioticus.
unpublished (1994)
107E Subfamily
CYP107E1 Micromosospora griseorubida
GenEMBL D16098 (2168bp)
Inouye,M., Takada,Y., Muto,N., Horinouchi,S. and Beppu,T.
Cloning and nucleotide sequences of a gene governing mycinamicinIV
hydroxylation.
unpublished (1993)
CYP107E2 Saccharopolyspora erythraea NRRL23338
SACE_1426, se: 1577490,1578686 (+) STRAND
58% to 107E1, 56% to 107N1
MPEPRPYPFSAAERLNLDPFYARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFS
RAAVLEKDEPRMRPGITGGGILSMDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLV
DRMIEHGSPADLVEEFALPLPITVICELLGVPYEDRDDFREWSDAFLSTTKLTPEQVVDY
MDRMFGYMAGLIAKRRVDPQDDLMSALIEARDEHDKLTEQEMVQLAAGILVAGHETTATQ
IPNFVYVLLTHPDQLEGLLADLDGLPRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVR
AGEPVLVSASSANRDEAVFDDPDRLDLTRENNAHIGFGHGPHHCLGAQLARLELQVGLRT
LLTRLPGLRFAGGEDDVVWKEGMLVRGPSKLEVAWQSE
CYP107E3 Salinispora tropica (marine actinomycete)
Strop_2770 complement(3139855..3141042)
59% TO CYP107E2 Saccharopolyspora erythraea
52% to CYP107E1 D16098 Micromosospora griseorubida
MTIDQEIRKYPFCESPGIGIDPTYGLLRSTEPLARVQLPYGEVSWLATRYEDVKTVLTDP
RFSRAAAQGKDQPRTREEMTYEGIIGLDPPDHTRLRKLAGKALTARRVNAIRADAQRIAN
EYVDEMIAKGSPGDLVELFALPYPVTVICELLGVPFEDRAQFRIWTEGLTSTSEQLMVYA
EQLFGYMGKLVAQRREEPTDDLLGALVKARDEGDRLTEQELLSIAGVGLLLTGVETVSTH
IPNFVYALLTHPELMAQLRADRSLVPAAVEELLRMIPLNPAAMFPRYAVEDVTLSGITVR
AGEPVLVSLPGANRDPEVFENPETFDFTREQNPHVAFGHGPHHCLGAQLARMELQVALHT
VLDRFPDLSLADGDEGVSWKSGLLVRGPSRLLVAW
CYP107E4 Actinoplanes sp. ATCC 53771
GenEMBL FJ754024
Prior,J.E., Shokati,T., Christians,U. and Gill,R.T.
Identification and characterization of a bacterial cytochrome P450
for the metabolism of diclofenac
61% to CYP107E2
CYP107E5 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_8067
57% to CYP107E2 Saccharopolyspora erythraea NRRL23338
CYP107E6 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE8636 56% to CYP107E2
CYP107E7 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY603 56% to CYP107E2
CYP107E8 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6929 64% to CYP107E2
107F Subfamily
CYP107F1 Streptomyces griseus
GenEMBL D45916 (2787bp) AB018074 CDS 341-1561
Ueda,K. and Horinouchi,S.
Cloning and Nucleotide Sequence of a Gene Involved in Redbrown
Pigment Biosynthesis in S. griseus
Unpublished (1995)
CYP107F1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR6619
One amino acid difference with D45916 sequence
CYP107F2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV1171 55% to 107F1
this subfamily is on the outskirts of CYP107
107G Subfamily
CYP107G1 Streptomyces hygroscopicus
GenEMBL X86780 (107379bp)
complement (91764-92978)
rapN
107H Subfamily
CYP107H1 Bacillus subtilis
GenEMBL U51868 (10153bp) Z99119, AF008220
coding region 7164-8351
pimelic acid biosynthesis
gene name bioI
107J Subfamily
CYP107J1 Bacillus subtilis
GenEMBL Y11043 U93876, Z99117
Belitsky, B. R., M. C. Gustafsson, A. L. Sonenshein, and C. Von
Wachenfeldt.
An lrp-like gene of Bacillus subtilis involved in
branched-chain amino acid transport. J Bacteriol. 179, 5448-57
(1997).
gene name cypA 42.6% identical to 107B1
also called yrdE
CYP107J2 Bacillus anthracis str. Ames
GenPept AAP26475
58% to 107J1 cypA of Bacillus subtilis
1 MAMKNKVGIR IEDGINLASA QFKEDAYEIY KESRKVQPVL FVNKTELGAE WLITRYEDAL
61 PLLKDNRLKK DPANVFSQDT LNVFLTVDNS DYLTTHMLNS DPPNHNRLRS LVQKVFTPKM
121 IAQLEGRIQD IADDLLNEVE RKGSLNLVDD YSFPLPIIVI SEMLGIPKED QAKFRIWSHA
181 VIAYPETPEE IKETEKQLSE FITYLQYLVD MKRKEPKEDL VSALILAESE GHKLSARELY
241 SMIMLLIVAG HETTVNLITN TVLALLENPN QLQLLKENPK LIDAAIEEGL RYYSPVEVTT
301 SRWADEPFQI HDQTIEKGDM VVIALAAANR DETVFENPEV FDITRENNRH IAFGHGSHFC
361 LGAPLARLEA KIAITTLFER MPELQIKGNR EDIKWQGNYL MRSLEELPLT F
CYP107J3 Bacillus cereus ATCC 14579
GenPept AAP09568
59% to 107J1 cypA Y11043 Bacillus subtilis
1 MKNKVGLSIE DGINLASAQF KEDAYEIYKE SRKKQPILFV NQVEIGKEWL ITRYEDALPL
61 LKDNRLKKDW TNVFSQDIKN MYLSVDNSDH LTTHMLNSDP PNHSRLRSLV QKAFTPKMIA
121 QLDGRIQRIA DDLISDIERK GTLNLVDDYS FPLPIIVISE MLGIPKEDQA KFRIWSHAVI
181 ASPETPEEIK ETEKQLSEFI TYLQYLVDIK RKEPKEDLVS ALILAESEGH KLSARELYSM
241 IMLLIVAGHE TTVNLITNTV LALLENPNQL QLLKDNPKLI DSAIEEGLRY YSPVEVTTAR
301 WAAEPFQIHH QTIQKGDMVI IALASANRDE TVFENPEIFD ITRENNRHIA FGHGSHFCLG
361 APLARLEAKI AITTLFNRMP ELQIKGNREE IKWQGNYLMR SLEELPLTF
CYP107J4P Bacillus cereus ATCC 14579
GenPept AAP09593
46% to CYP107J3 in same genomic region
47% to CYP107Y1 SAV2377 AP005030 Streptomyces avermitilis
50% to 107H1
1 MKEPQLQQHL EKFIQYIEAL VNEKRLNPDA DLISELVQTK EQEDKLSNNE LLSTIWLLII
61 AGHETTVNLI SNGLLALLQH PEQMNLIREN PSLIPSAVDE LLRHSGPVMF ISRLASEDMT
121 IHGKRIPKGD LVLLSLTAAN IDPQKFTYPE TLNISREENN HLAFGAGIHH CLGAPLARLE
181 GQIALGTLLQ RLPNLRLAIK PDQLNYNHSK IRSLVNLPVV F
CYP107K1 Bacillus subtilis
GenEMBL AL009126 Z99113 comp(76702-77832)
polyketide hydroxylase pksS
just over 41% identical to CYP107J1
CYP107L1 Streptomyces venezuelae
GenEMBL AF087022
GenEMBL AF079139 CDS 122..1372
pikC gene
function="catalyzes the hydroxylation of YC-17 into
methymycin and neomethymycin and narbomycin into
pikromycin"
51% to 107B1 47% to 107A1 44% to AF254925 42% to 107J1
41% to AL049754 new CYP107 subfamily
CYP107L2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV1987 60% to 107L1 from Streptomyces venezuelae
CYP107L3 Streptomyces tubercidicus strain I-1529
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name CypLA
60% to CYP107L1 91% to 107L4
CYP107L4 Streptomyces tubercidicus strain R-922
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name CypLC
61% to CYP107L1 91% to 107L3
CYP107L5 Streptomyces sp.
GenEMBL BD133547
68% to 107L2
3 LIAGHETTVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAE 182
183 PLEIGGTVIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGFGTHRC 344
CYP107L6 Streptomyces sp.
GenEMBL BD133544
72% to 107L2
MGHEHVIDLGEYGPGFTENPHPVYAELRARGPVHRVRLPKHDAHHEAWLVVGYEEARAAL
ADPRLSKDGSTIGVTFLDEELIGKYLLIADPPQHTRLRGLIAREFTGRRVERLRPRVQEI
TDSLLDEMLPRGRADLVESFAYPLPLTVICELLGVPEIDRAAFRKLSTEAVAPTSGESEY
AAFVQLAAYLEELVEEKRCAPPADDLLSALIRTTDEDGDRLSPAELRGMAFILLIAGHET
TVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAEPLEIGGT
VIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGHGIHFCLGAPLARLEARVA
LRALLERCPGLTPDGAPGEWLPGMLIRGVRSLPVRW*
CYP107L7P Streptomyces narbonensis
GenEMBL AF521878 13901..14661
desosamine biosynthetic gene cluster
91% to 107L1
gene= nbmL
note= frameshift and deleltion generates premature
stop codon and truncated protein"
MSRTHQGTTASRPVLDLAALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDTARAVLADPRFSKDWRNSATPPTEAEAALSHNMLESDPRCGPT
(deletion)
ALRADLTLLDGAVEEMLRYGGPVESATYRFPVEPVDLDGTVLPAGETVLVVLAD
AHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCTGAPLARMEARIAVRALLERCPDLALD
VSPGELFWYPNPMIRGLESLPIRWRSGREAGRRVPVEPACRP*
CYP107L8 Streptomyces sp. HK803
GenEMBL AY354515 complement(72672..73871)
Gene = plmS2
56% to CYP107L6
MVTVDLSAYGPGFFTDPYPYYARLREAGPVHEIVLADGDRFWLI
VGYDEARAALADPRLAKSLDPPSEDERHVLITDPPDHTRLRRLVSREFTARRVEAMRP
RVQEITDGLLDEMVAGRRRADLVPSLGSPLPITVLCELLGVPLADREDFRGWTERVLV
PAEPDTIAWWKSRGFAQAGMALTDYLKNMIEDKRRSTPTGDLISSLLRTTAEDNDRLS
AAELHSMVFILIVAGHETTANLITNGVRALLAHPEQLAALRTDPEGLIDQAVEEMLRY
DGPVETSTKRFTLEAVRYGATKIPPGETLLVSIAATGRDPAQFERPDTFDIHRGTTGT
RSGHVAFGHGIHFCLGAGLARMESRVAILTLLRRCPDLALDIDPAGLDWLPGIRVRGV
RSLPVRW
CYP107L9 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
62% to 107L6 before frameshift at C-term
clone name SP0854
CYP107L10 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1278
59% to CYP107L1
CYP107L11 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1279
60% to CYP107L1
CYP107M1 Actinomadura hibisca
GenEMBL D87924CDS complement(6299..7534)
45% to AF127374 CDS 3226..4458 44% to AF254925
45% to 107D1 44% to 107G1, 107E1 new subfamily in 107
CYP107N1 Streptomyces lavendulae
GenEMBL AF127374 CDS 3226..4458
50% to 107D1 52% to AF254925 47% to 107E1 new subfamily in 107
CYP107N3 Streptomyces peucetis
AJ605544.1
SP0881
91% to 107N1
VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW
LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT
PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT
WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE
LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV
DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP
HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*
CYP107P1 Streptomyces coelicolor cosmid H10
GenEMBL AL049754 CDS complement(10413..11648)
41% to AF087022 40% to 107B1 40% tp 107G1
40% to 107D1 new subfamily in 107
cloned and expressed by David Lamb and Steve Kelly
CYP107P2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV4539 86% to 107P1 from Streptomyces coelicolor
CYP107P3 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
78% to 107P2 missing 156 aa at N-term
C-term may be frameshifted
clone name SP0887
CYP107P4 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9576
75% to CYP107P1 Streptomyces coelicolor
CYP107P5 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE4373 66% to CYP107P1
CYP107P6 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY4628 72% to CYP107P1
CYP107P7 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR3408
72% to CYP107P2
CYP107Q1 Amycolatopsis mediterranei
GeEMBL AF040571 CDS complement(781..>2316)
66% to AF040570 comp(68704..69969) 43% to 107C1
41% to 107B1 40% to 107A1 new subfamily in 107
CYP107Q2 Amycolatopsis mediterranei
GenEMBL AF040570 CDS comp (68704..69969)
66% to AF040571 complement(781..>2316) new subfamily in 107
CYP107R1 Streptomyces maritimus
GenEMBL AF254925 CDS comp (18384..19589)
gene="encR"
53% to AF127374 CDS 3226..4458 49% to 107E1 new subfamily in 107
MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGE
AWLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVA
GVFTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDD
REQLRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDR
EEGLLRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVE
ELLRFIPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDID
RSPNPHVAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVR
GPKTLPVKW
CYP107S1 Pseudomonas aeruginosa
NZ_AABQ07000001
NC_002516 3741011..3742267
locus_tag = PA3331
47% to 107B1
CYP107T1 Streptomyces coelicolor
StH63 [Full Sequence] Sanger cosmid
51% to CYP107L1 CDS 16028-17233
cloned and expressed by David Lamb and Steve Kelly
CYP107U1 Streptomyces coelicolor
StE41 [Full Sequence] Sanger cosmid
comp(7438-8739) 44% to CYP107B1
cloned and expressed by David Lamb and Steve Kelly
CYP107U2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV3536 85% to 107U1 from Streptomyces coelicolor
CYP107U3 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
84% to 107U1 missing 90 aa at N-term
clone name SP0819
CYP107U4 Streptomyces scabies
SCAB54411
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
90% to 107U1 Streptomyces coelicolor
CYP107U5 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_8392
80% to CYP107U2 Streptomyces avermitilis
CYP107U6 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE3655 80% to CYP107U4
CYP107U7 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY3619 82% to CYP107U4
CYP107U8 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR4436
83% to CYP107U4
CYP107V1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV3519 low 40% range with some 107 subfamilies
CYP107W1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2894_olmB low 40% to 107 subfamilies
CYP107X1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV6249 49% to 107L1 from Streptomyces venezuelae
CYP107X2 Saccharopolyspora erythraea NRRL23338
SACE_1158, se:1279482,1280657 (-) STRAND
57% to 107X1
MRPVEIDDEFVTCPHAAYARLREQGPVHRAVAPDGSRVWLVTRYDDVRAALADSRLSLDK
AHATDGYRGLSLPPALDANLLNMDAPEHTRLRRTVTRAFTAHRTELLRPRVQEIADELLA
AVAGQERAELMSAFAGPLPITVICELLGVDARDRPDFRAWTDEMLAPSTPDRARDSLRSL
YAFLVDLIARKRAEPGADMPSTLVGLRDEDGSLTEDELTSTAFLVLFAGYENTVNLIGNG
LAALLARPAQLAAVRSDRGLLPSTVEELLRFDPPPQLSIRRFPKEDLEIGGVRIPAGDTV
LLSLVSAHHDPARFTSPGELIPDRADNAHLAFGHGPHFCIGAPLARMEAEVAFSTVLTRF
PALSLAVDPAELRWRPSFRNRGLRELPVRLS
CYP107X3 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_2046
67% to CYP107X1 Streptomyces avermitilis
CYP107X4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY8268 66% to CYP107X1
CYP107Y1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2377 50% to 107L1 from Streptomyces venezuelae
CYP107Z1 Streptomyces rimosus ssp. paromyceticus strain R-2374
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema11
96% to CYP107Z2v1
CYP107Z2v1 Streptomyces albofaciens strain C-0083
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema8
96% to 107Z2v2 and CYP107Z1
CYP107Z2v2 Streptomyces rimosus ssp. paromyceticus strain BOEH-4355
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema3
96% to CYP107Z2v1 95% to CYP107Z1
CYP107Z3 Streptomyces sp. strain IHS-0435
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema7
76% to 107Z12
CYP107Z4 Streptomyces lydicus strain NRAB-0114
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema16
82% to 107Z12
CYP107Z5V1 Streptomyces lydicus strain NRRL-2433
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema15
97% to 107Z5v3
CYP107Z5v2 Streptomyces chattanoogensis DSM-40241
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema6
1 aa diff to CYP107Z5v3
CYP107Z5v3 Streptomyces lydicus strain R-401
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema4
100% to S. kasugaensis strain A/96
CYP107Z5v3 Streptomyces kasugaensis strain A/96
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema10
100% to S. lydicus strain R-401
CYP107Z6 Streptomyces sp. strain I-1525
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema5
85% to CYP107Z8
CYP107Z7 Streptomyces tubercidicus strain DSM-40261
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema17
90% to CYP107Z8
CYP107Z8 Streptomyces platensis strain Tu-3077
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema13
89% to CYP107Z9
CYP107Z9 Streptomyces tubercidicus strain NRAA-7027
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema12
89% to CYP107Z8
CYP107Z10 Streptomyces tubercidicus strain I-1529
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema2
90% to CYP107Z11
CYP107Z10 Streptomyces platensis strain I-1548
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema14
100% to S. tubercidicus strain I-1529
CYP107Z11 Streptomyces platensis strain NRAA-7479
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema9
92% to 107Z12
CYP107Z12 Streptomyces tubercidicus strain R-922
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name Ema1
92% to CYP107Z11
CYP107Z13 Streptomyces ahygroscopicus
No accession number
Li Mei
Submitted to nomenclature committee Nov. 25, 2008
83% to CYP107Z3
CYP107AA1 Mycobacterium smegmatis
MSMEG3142 TIGR
RubU (pksS)
45% to 107B1 43% to CYP107AB1P
41% to CYP105S2 Mycobacterium vanbaalenii
MTPYSRRDRNH
MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLT
DPRIGKDGAAASALFPPGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAF
TAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELL
GVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPAD
DVLSSLVHRRDGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRN
PEQLRAVRADRSLLPRAVEEALRFESPLNTATVRYTSAPVTVGDVEIPSG
ELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM
EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIAS
TMREWSGSLPSSGEADSSFAH
CYP107AB1P Mycobacterium smegmatis
45% to CYP107B1
43% to CYP107AA1
MILDEQFAQDPEGLYRMLRSEAPVCEVELIGGVRGWLVTRYADVMALLKD
PRVSKDHTSALPRLAPDRVRPYISPQLHNHMLNLDPPEHTRLRRLVVQAF
TPKALARMQPVIDAIADELLDDIDLRSGDEPIDLMADYAEPLPIQVIAEL
LGVAVEYA*PFRAAVTPLLMSVTVEEKAESGRATIEILNAVIDEKIREPG
EDLLSGMIGASVDGHGLTRDELMAMCFLLITAGYETTVNLIGNGTLALID
NPSQLEKVRENPDLTAGAVEEILRFDGPVNIATWRYATADIDVDGVVIPA
NEQIFLSLLSANRDTGRFENADRFDIERNTRGHIAFGHGIHYCLGAPLAR
MEGVTAIGRIVQRYDSITLDPTAELRYHNGTLMHGLKSLPVRLTRVPQPRP
CYP107AC1 Streptomyces atroolivaceus
GenEMBL AF484556 60948..62147
leinamycin biosynthetic gene cluster
48% to 107N1
gene = LnmA
MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGE
GWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSK
AFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDR
GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD
DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEEL
LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITRE
KNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGP
QRLPIAW
CYP107AD1 Streptomyces hygroscopicus
GenEMBL AF521896 4248..5489
ansamycin biosynthesis gene cluster
43% to 107X1
gene = gdnH
MSGRHFEQGERGTAMADTPEEELRILDPQSVAQELRKHGPPRQI
TMHGTTAWLVSRYEEVRDCLGHPGMSPAAAYAASQGQTNPVSGLFEDTVAGTNPPQHT
RLRRLLAKAFTVRRVESLRPRVQEITDTLLDRIAVDGRADLVSALAIPLPMQVICELL
GVPIADRTEFHQWADLMLTPPLDPDTAARSQDASAKLWTYMEDLAEARRKAPEDDLIS
DLMSAHEDDRLSHREVVATARMMLIAGYELTGSFISNAVFSLLSQPDQMELLRKDPEL
AGRGLEELLRHAGPGILIVRFANEDVEIGSVSIRAGDQVLLDMDAAHSDPAHFTDGER
LDLTRDSAVHLQFGHGIHYCIGAPLARVEGQIALESLVRRFPGLRLSVPAAEISHSKN
PFIRSLTALPVEFEAQQPVAG
CYP107AE1 Streptomyces sp.
GenEMBL BD133545
50% to 107X1
VILLKSLAANGLTASSCFTVSPLPIRSASPSIAFLTSSSERDSGVRNDRPSDAQPAIARF
RFPTPPHPRNPTQPHPTPPRPSPTDDPLQAPTFFADPYPTYARLRDTAPVLKVPTGSGGG
GRHSYVVTGYAEAREAFTDPRLSKDTASFFAGRPSQRDLHPAVSRNMLATDPPQHARLRA
LVTKAFTTGAVARLRPYISSLVDELLDTWPTHGTVDLIADLAVPLPVTVICELLGVPDSD
RASVRTWSSDLFAAGDPQRIDAASHAVGDYMTALVAAKRTAPGDSLLDDLIAVRDGQDHL
SEDELVSLAVLLLVAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDS
PVGIATFRFSTEALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFG
HGIHRCLGAPLARAEAELALHAVITRYPQAALATPPETLPWRHTRLTRGLASLPITLRDH
PK*
CYP107AE2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY639 66% to CYP107AE1
CYP107AE3 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR420
69% to CYP107AE2
CYP107AF1 Streptomyces collinus DSM2012
GenEMBL AF293355 24259..25518
Gene = rubU
rubrinomycin gene cluster
52% to 107B1
MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPN
GLRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPH
VLSVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLME
ALAFPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEA
KRNEPADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHP
EVREQLAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGA
AGRDPDRYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLR
LAADPDELSWRSSLMMRGLEELPVFTA
CYP107AG1 Streptomyces atroolivaceus
GenEMBL AF484556 complement(120436..121638)
Gene = LnmZ
leinamycin biosynthetic gene cluster
49% to 107E1
MSTEVETEKPAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLP
FGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRT
LVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVP
EDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIEA
RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIPAA
VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV
IDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEWKADMIIRA
PRVMHVEW
CYP107AH1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
50% to 107L6 missing about 42 aa at N-term
clone name SP0749
CYP107AJ1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
52% to 107B1 frameshifted C-term
clone name SP0908
CYP107AK1 Streptomyces scabies
SCAB79691
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
48% to 107AF1, 47% to 107B1
CYP107AL1 Streptomyces scabies
SCAB63301
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
45% to 107AC1, 45% to 107N1, 45% to 107M1
CYP107AM1 Streptomyces scabies
SCAB44031
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
41% to 107AC1, 42% to 107E1
CYP107AM2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7397
68% to CYP107AM1 Streptomyces scabies SCAB44031
CYP107AN1 Bradyrhizobium japonicum USDA 110
GenPept BAC51802
NC_004463 complete genome complement(7193424..7194725)
41% to 133B1v1 45% to 107L1
formerly CYP107AA1, but this name was also given to
an M. smegmatis sequence so one had to be changed.
1 MVTPGSGAAI GVFVSCGNRF EVTMNEQAQP AGGDPLFNPL SPDFIRNPYP HYDRLRAIDP
61 IHVTPFGQFV ASRHADVSLV MRDKRFGKDF VERSKRRYSE KIMDEPVFRS MSHWMLQADP
121 PDHTRLRGLV VKAFTARRVE DMRPRIQEIV DEAIDAVIDR GHMDLIEDFA FRLPVTIICD
181 MLGIPEDHRE VFYKSSRDGG RLLDPVPLTP EEIAKGNAGN MMAQMYFQQL FELRRRNPAD
241 DLTTQLVQAE EDGNKLTNEE LTANIILLFG AGHETTVNLI GNGLLALHRN PDQLALLKAR
301 PELMVNAIEE FLRYDSSVQM TGRVTLEDID DLGGRKIPKG ETVLCLLGSA NRDPAVYPDR
361 PDRLDVTRPN VKPLSFGGGI HFCLGAQLAR IEAEIAIATL LRRLPDLRID DVENPEWRPT
421 FVLRGLKSLP ASW
CYP107AP1 Streptomyces rochei plasmid pSLA2-L
NC_004808 Links 87725..88939
49% to 107A1
note="ORF37 lankamycin biosynthesis protein
formerly CYP107AB1 but that name was already assigned
to an M. smegmatis seq. (my error)
MNQPQLPEIPALNSELFHTDQYATYREILEQRPVTRVRFYDGSL
VWLVNRHEDVRAALTDPRLSNDPMKQSDIDLSAATGIPADLIEYFQRNMFRSDEPDHG
RLRKLVTREFTVRRINALRPRIRQIADDLLEKFAATGGGDLVEALARPLPLTVMCELL
GVPEEDRADFQTWSQHIVESSPEFAERNAVSYRSLFECVRSLIRRRRDEPGDDLLSAL
VDLRDVADRLSENELISTVFLLLVAGIETTVNVLGTGTFLLLTHPGELARLRADGALL
GPAVEEMLRYMAPIEITSRHTLEPVEIGGVSIDAQSTVLINLAAANRDPARFEDPQSF
RVDRNDGGHLTFGHGIHYCLGAALARAEAEVTFEALLERFPDLRLAASASDLTWRHAF
MRGPVELPVSWG
CYP107AQ1 Saccharopolyspora erythraea NRRL23338
SACE_0125, se:152305,153462 (-) STRAND
50% to CYP107P1
MFDTADPAFVADPYPCFAELRRRGEVHRHPGLGMAVAVSHAAASEVLRHRGLGRIWVDAQ
PAADFPAFNLLHRTSLLETEGAEHTRLRRSISAAFARGHVERVRPWVAGLADALVGGLVE
RGGGDVVEEVAAPLPVQVIAELLGVPESDRNLLRPWSNAIVKMYEPGLPERRRAAAESAA
AEFAEYMRALADRRRSAPADDMVSDLVAAEELSADEVVGTAVLLLMAGHEASVNLVANGV
LALLRHPGQWRRLVDDPGLVPTAVEELIRYDSPLQLFERTAVEDVVVAGHRVAAGSKIAA
LLGAAARDPEVFESPDVLDVGRQPNPHLGFGAGIHYCLGAPLARVEAAAALSALVRLAPR
LEQAGEPVRRPEFVIRGLRELPVSV
CYP107AR1 Saccharopolyspora erythraea NRRL23338
SACE_0651, se:714930,716198 (-) STRAND
44% to CYP107Y1
VQPDQSPTPRPESRHSPAAACPHAAVHREERPGGLVTWQISAFSEARAALGDSRFSKDPR
RLGEALRAGGRSMFAEYGDNLLDNLLNSDPPDHTRLRRLVGKAFSPATIERLGPTTQRLA
DELVASMLPAGRADLLAQFAYPFAFGVIARVLGLPPDSYRIFQRWTESMTAPREQGTDRM
VAARHLCEHVTELVRRSREWLASAPAETLLDELVSARDDGDRLSENELVATVLLLIIAGH
ETTVNLIGNGVHALLQHPGQLALLRDHPDLIDGAVEELLRFQPPISKTTLRVTTTDVEVA
GTEIPAGSIVNVLVPAANRDQRQFPDADRLDITRPPSAHMSFGHGIHYCIGAPLARMEGR
IAIGALLRGLPGLRLAEPAAEIPWRASNILRGLQRLPVRFDSAGADDEVRDRRHAGAARV
HA
CYP107AS1 Saccharopolyspora erythraea NRRL23338
SACE_2922, se: 3203418,3204656 (+) STRAND,
48% to CYP107D1
MTESIQRDADSQEAACPHARAYPFGDPGALDLDPDYARVRDEEPLTRIRMPYGEQGWLVT
RYDDVRTVLADPRFSRSEVLKRDVPRPTPQQVERPGTLVTTDPPEHGRLRRLVAGAFTHR
RAESMRPRIRGVVDELVDEMLAGDKPADLVAAVSMPLPVNVICELLGVPREDRHVFHSGA
VLSDYTVPADEREATFKSLADYLAVLIAERRARPEGPGDDVLGALISARDTDGDRLSEDE
LIELWVDILVAGYASIMSVTPDMVVTLLTERDRWDGLVADPGGVPDAVEEMLRVMPTIIE
SGHSRVATEDVEIAGGTVRAGEAVLPCLPAANRDPAVFDAAEEMRLDRDAGKHIAFGFGP
HYCLGASLARVQLQSVLTALVRKVPTLDLVEAVREDSTRVAAAVQGQLLVTW
CYP107AT1 Saccharopolyspora erythraea NRRL23338
SACE_4142, se: 4611465,4612715 (-) STRAND
56% to CYP107AT2, 47% to CYP107AU1
MSVGDIDTPSGEFDFAANLLPFDPLDPAFQADPYPFFRLVRETAPALCTQPGMWVVTGFR
ECSAVLRNPKFGHGDGRLVASQITHDAEGNVVRPFVFMDPPDHTRIRSLVTKAFSARMVE
RLRPTAERLVGELLAAAMSGPADEPVDLMAELAFALPSNLISELLGMPPQDKPLFEQWSS
ALGRGLDPDFMLSPEEMQRRDQARTEFDGYFAELARRRRAEPADDLVSALVAVEEDGRNL
SMSELVSTCRLLLSAGYLSTAHLIGNGVNALLRHPEQFEWFRAHPDQVAGVVEELLRYDS
PVQTAGMRTALQDTEIGDQPVSAGEGAMLLVGAANRDPAAFPDPDRLDVSRKPERNLGFG
IGAHFCVGAPLARLTTQVALTALAGLRVELATDDAPRINNLVLRGFAELPVFLRAA
CYP107AT2 Saccharopolyspora erythraea NRRL23338
SACE_4144, se: 4614537,4615769 (-) STRAND
56% to CYP107AT1, 47% to CYP107AU1
MSTTEGAPPVDSNVVRQLLLFDPFDPEFRADPHRVYREIRESGPVTATPGGLWLVSGHRQ
VSAVLRDQAFGWGEAELAAGHFTTDDEGNTVRPLTFADPPEHTRIRSLVTSAFSARIVER
LRPRAQELARESLAAALAGGGSADVIQQVAYPLTGRLLCELLGVDPEYQERFRAWAEAMG
RGLDPDFMQSPDQLARREEARAHFHEYFAELAARRRAEPGDDLVSALVAVEQEGDRLTAT
ELVVTCTLLLSAGYATTVHLIGNGMLALLENPDQLAWLRANPGRVGDAVEEVLRFDGPIQ
LVSRVALRDTEVDGHAVAAGSPVLLLLAAANRDPAVFDDPDRLDVSRKPGRNLGFGVGIH
FCLGAPLARLTAQAALSLLVEHELVLDGPRPAPTGSLVLRGLAELPLRSA
CYP107AU1 Saccharopolyspora erythraea NRRL23338
SACE_5309, se: 5939205,5940431 (+) STRAND
47% to CYP107AT1, 47% to CYP107AT2
MTAGTNNAGRLGALAEAVLGYNPVDPEYHANAHEHHRRMAERGPIFRTPGGMWTAVSHAA
CSAVLRDDRFGHDPGSAAQNLFDSTQRPSVAQRSFEFMDGPDHSRLRRLVNRAFTARRVE
RLRPAVRTLADQLLTDVSGRIDVLADFILPLAMTTIVDMLGAPTEDNHLFRAWAEPIVRG
LDPDFLLSSSELAAREQANAEFAEYFDRLVALRRAEPKDDLISALIAVEDDGVVLSGNEL
ISMCLLLLAAGHESIMHLVGNGTVALLRDEDQLEHFRGHPGEVTNAVNELLRYDPPVVLL
VRTALADAEVLGNRVRRGEIVWLQIGAANRDPAVFPDPDRLDLTRDTGGSLAFGLGIHFC
IGASLARLEAAAALSALLHRDVALASEQLVHQKNVVIRGYEEVPVVLR
CYP107AV1 Saccharopolyspora erythraea NRRL23338
SACE_5939, se: 6665300,6666601 (+) STRAND
44% to 107L1, 43% to 107AT2, 41% to 107AN1
MTTAEPAETGSLAELNLGMRLVLHGAVTWSIARLGDPVARLLHSPWRRDPYPIYRQLRAR
GPLVRSRLGVWAASTYEVCDAVLRDRRFGVRTSDGSYGDPTAAAVGLQLSLLELDPPDHT
RLRKLAAPAFRPRKLENYRQRIEDTAHELLDRALAKGEFDLIRDFATPLPIRVICELLGL
PELGAERLAVHGAALSGALDGIRSIRHLRRMRASTLELNELFGDLIEQRRRQPGEDIVSD
LVTALDQDRLDSTELVQMCDLLLVAGFETTVNLIGNGVLALLERPDQWRLLCDDPDQAVG
VVEETLRWDPPVQTTMRVAHEPVEVAGRLLPRNSAVLPMLGAAGRDPAVHFAPDRFDITR
GTRGDHLAFSSGIHYCLGAPLARLESEIAFRCLATRVPELRRSGALVRRPTSVIHGLSAL
PVAASKATAGGRR
CYP107AW1 Salinispora tropica (marine actinomycete)
Strop_2290 complement(2583447..2584649)
49% to CYP107B1 M83110 Saccharopolyspora erythraea
MESVTSTSAPPPVPYIADPYPALARIRANGPVSILHSDEGIPMWVIARYRNVRAALADPR
FGQDARRAQTLADNRVAGVTLGGDVIHMLNSDPPDHTRLRHLVQGAFTARRVAAMRPLVE
RITTSLLDGVGGRQTVDLVQDFAFPLPMLVICELLGFPAEERDAYRSWSTAILTHNDDPA
AFATALRDMTDYIEVQLRHRRARPGEDLLTELLAARDAGQLTDDEIVGMVFLLLIGGHET
TVNLLGTATLALVRNPDQHRWLLANPHALSEAIDEFLRYESPVAMATLRFTTAPVTVDDV
VIPAGELVLVSLGGANRDPDRFPDADRLILDRRDTGHLAFGHGLHRCLGAFLGKLEGEVA
LGALLGRYPGLTLAAEVRQLRWRDTIMLRGLESLPVSLHG
CYP107AX1 Salinispora tropica (marine actinomycete)
Strop_2367 2663162..2664352
47% to CYP107X1 SAV6249 AP005046 Streptomyces avermitilis
MTSRPTAVFDQCLLRDPHSRYNALRDQAPVHHVLTPDGAPAWLVTRYNDVRAAFTDPRLS
VDKRFSGTDGEHGSSLPPELDAHLLNRDPPDHTRLRRLAAAACTPRRVADLHPAVERIVS
TLLDGLAGHDRAELIGSLASPLPLQVMHELLGLPTQANIDFRTWTNTLLSADANQPAQSR
AAMANMRRFLIEQLAHKRAQPGDDLLTGLLAAREDDDRLTDDELVAMVFLLMFAGYDNTA
ALIGTVTHALLTNAELHEAVRGGSLALDELIDEVLRWNPAFPLAVRRFAREPITIAGQTI
PAGDRIWLCLASANRDPAQFTQPDELGIIGLRRSHLSFGHGIHYCLGAPLARLQTTIAVT
SLLNRFPEMRLAVPAHDIRWRESFRLRGLIALPVYL
CYP107AY1 Salinispora tropica (marine actinomycete)
Strop_4427 complement(5021489..5022637)
49% to CYP107X1 SAV6249 AP005046 Streptomyces avermitilis
MSQDPTMRAELAPIPRSGARLGQEYDQLRNAGDVHQVLLPDSSLAWLVTNPKLVSRALTD
PRLALNRRHSRGSWSGFALPPALDANLLNLDAPDHTRLRRLVGPAFSPQRVSALRPRIRR
TAEHLLDTLVATSGPVDLVTGYCTPLSVQVIADLMGVPEAGRADLRTWTDTMLTSYPPDR
DAIRQAVVELHGYVVDLIDTKRQQPGDDLLSALVTIEQDGDRLTRDELTSLAFLILFAGY
ENTANLIASTVLRLLDHGGLRGVQLPEAIEETLRLEPPAPAAVRRFPTEEMTIGGATIPA
GDIVLLSIAAATRGTAGNAARLAFGNGPHFCLGAALARVEAEEALTVLARRLPDLALALP
VAQVRWRPTFRTHGPAELLVTW
CYP107AZ1 Roseiflexus sp. RS-1, complete genome.
GenEMBL CP000686 REGION: 945215..946423
49% to CYP107AN1
MHHPTEPPPELWSAAAISDPYPIYDRLRAEQPIRWTGGDWQIFR
YADAQALLRDPRLGADRLQVDPQWLIASGLEPLFKTRDSMMLFADPPDHTRLRTLVHR
AFTPRVVESYRPLVQRIVDQLLDAAAARGAIELIGEFAYPLPVTVIAHMLGVPVNMHD
QFRRWSDSLAAFIGGTTRPEADVLPAALKAVLEMTDFFLALVAERRRAPRDDLLSALA
QAEDGGDRLSEQELVANSILLLLAGHETTTNLIGNGMLALMRHPDQFALLRDHPELTP
SAIEELLRYDSPVQVTSRRALTDIEFQGHRIEEGQAVTVFIGAANRDPAQYQDPARLD
VTRGDVRHLSFGHGPHYCLGAPLARLEGQVAISALVRRFPHMRTLDEQVVWRDNFALR
GLQSLHIELE
CYP107BA1 Roseiflexus sp. RS-1, complete genome.
GenEMBL CP000686 REGION: 4471138-4472327 (-) strand
Frameshift at 4471920
46% to 107B1, 46% to CYP107AZ1
4472327 MTPTIVARLASPEFLADPYPVYRQLIEQTPVFWLPHANAPGGMWCIARYDDIAFVLREAPIFKDT 4472133
4472132 SRIAPPDTLTPLDRAMLQRDPPDHTRLRRLASHAFTPRRVHDLMPRIEQI 4471983
4471982 SLDLIERIGARGEADFIADYA 4471920
4471920 PLPIIVIAELLGVPFEDHEQFSTWSDQIMAGSDSVLGGEEAARQSHQAMASLVDYFTTLI 4471741
4471740 RQRRHSPRDDLISALIAAHDAGDSLSEDELLGMCVLLLIAGHETTVNLIGNGLLTLLRH 4471564
4471563 PDQLNLLRRQSEYLTSAIEEMLRYESPVQRSTPRFAAEPFVIGGEQIEAGQQISLMFGAA 4471384
4471383 NRDPAHFSDPDRFDITRQPNPHLGFGMGIHYCLGAPLARIEARVAFTHILERLPAIRLAT 4471204
4471203 DTPAWKPVTWLRGLKSLPVLV* 4471138
CYP107BB1 Streptomyces sp. Tu6071
ABB69746
PlaO2
1 MDRVLDFLSS ADSAGELQPR LVELSRQETL PRVLLADGQE AWLVTRNEDV RTVLSDRSFT
61 RDVMGERARQ AGETPDGARS VNMDGRPHNE LRALVSKAFT VRRIEAMRPR IQAWTDELID
121 AMEETGPPAD LVAHLAVPLP ALAICELLGF PVEDRQVLSG WCERITRLGE GGPDQRAWQE
181 LSAYIARRVP VERAAARGGL APETSILTRL VHAHDSEDAL SMEELLSLTV VVLAGGLETT
241 QTAIGAGMVR LFRNPAQLDK VRADPDLVVP AVEEILRYQP VIDVNRVQVA TRTVRLGGQE
301 IRAGDLVQVS VNAANRDETV FPDSERCDVT RGPNPHLAFG YGAHHCLGAA LARLELKTAF
361 STLLRRLPDL RPAVPLESLG WRGGHVTLGL EELPVAW
CYP107BC1 Streptomyces sp. Tu6071
ABB69764
PlaO5
1 MTESLETTSP DPTRSGNSDT GATPGYTVPK QVNDMWREKP VRRFSMRDGR EAWLVTGRAE
61 VRTVLADPRF SRVEARRLDA VMSPAVIFTR PGILDMDPPE HTRLRRLVAG EFSARRMRAL
121 RPRIQQIADE LIGTMKAAGP PADLAEGLSY PLPIAVICEI LGVPYADRER FRAWADRVSA
181 PGTQPQEAMA ALRSLFDYMG GLVDDKHAHP DGSLLHGLVT ARDEQGRLDN EELVTLGCGL
241 LLAGYETTAT MLGKGLLALL DNPDQLAVVR SDPRAVPAAV SEVLRHVTPG VDPHTGLIRA
301 TTADVELGGT VIPAHSVVVA CNTAANFDPA TFRDPDRFDV TRENAAAHLT FGHGMHRCVG
361 AQLAQIELEA AFAALFPAIP GLRLAVPADE ITYTQSTLIR GLRSLPVLW
CYP107BD1 Frankia alni ACN14a
YP_713426.1, no CAJ# found for this seq
MAETGGFAEVGGVAQTGGAREIFDPRWRSDPYPLYRTLRESARCHWLSPARIGVLTRHADCVAVLQDSAW
GHVPMETSAFRPVTDQDEGLRSMLRANPPTHTRLRRLVSRAFTPARIARFRPMAEALAGELLAAAVDRGE
VDLVEAFTRPLPLRVICSLLGVPAHDEKVFSGWASALTRGLDPDQVLDPVERAQRTEATRAFADYFTALI
ARRRAEPADDLLSDLIAVQDQGDRLGADELLEICVLLLVAGYDTTVNLVANAVLALARDPGQYAALQANR
TLVPAAIEETLRHDPPVQWTGRTALTDTDLAGQAFRAGDGIILVAGAAHRDPAAFPDPDRFDLTRYASAS
APAARHLGFGHGLHYCLGAPLARLEAETMLTALLDRVARLEIVAEPTYRPHLAVRGVDALQIRLHPAG
CYP107BD2 Frankia sp. CcI3
YP_480713.1
ABD10984.1
57% to CAJ61859
53% to CYP107BE2 YP_001505774 EAN1pec
46% to CYP107AT2 Saccharopolyspora erythraea
46% to CYP164A2 Mycobacterium smegmatis
MDADSPSGAAAVGTPPAFGAFDPARRHDPYPSYHALREADPFYRLPLGAQQVTLLTRYQDCMHVLQDAAW
GRGEGGTNAWRSANSFDGGLRSLLGVNPPDHTRLRGLVSKAFTPRVISGLRPQITVLVESLLDAALAAGE
VDLIDAFARPLPLRIICDLLGVPVRDEETFRAWGTALTRGLDPDYLLTPDELALRGKATVEFDAYFTDLI
AARRARPTDDLLGLLVAVREQGDSLTEAELLELCALLLVAGYETTINLIGNAVLALLRDTDQLTALRADP
DLAPALVDETLRHDPPVQFVGRLALRGTEVAGHSFAAGEVGVIMLAAAGRDPRTFAEPDRFDIRRYAGPT
PAPRHLGFGLGIHYCLGAPLARLEAEIALQALVRRAGSLTPASDPPSYRPHLAVRGLETLPIRLSP
CYP107BE1 Frankia alni ACN14a
YP_714400.1
CAJ62848.1
57% to YP_001505774 EAN1pec
43% to CYP107AT2 Saccharopolyspora erythraea
MATVPASRSASERRSPLLAAFDAARQVDPYSTYRAIREADPLAGHDLAGHRVTLVTRHGDTAAVLQDPAF
GHGYKENISPFRPDGDADDGLESLLRSDPPDHTRLRRLVSRTFTPGTLVELAPDITSFVAGLLDAALEAG
EIDAIRALARPVPTRMICRLLGVPAADEKIFGEWSETLIRGIDPDFLLTPDEITERRRAARELDAYFRDL
IARVRVRPGTDLVSQLVAIHLGEDALTESEVLALCAVLLVAGHETTVNLIGGGVLALVQHPDQLALLRAD
PGLIPAAVEEMLRHDSPVQFIPRTALRDTEVGGRQFRRGEGALLLVGSANRDPDAFDEPDRFLVARYAGS
TPAARHFAFGTGVHYCLGAPLARMEAEIIFRLLLERTSELALIGSTPTYRNQSIIRGLQTLPLRLAA
CYP107BE2 Frankia sp. EAN1pec
YP_001505774.1
ABW10868.1
45% to CYP107AT2 Saccharopolyspora erythraea
MTTVGGMDTSEGGTSAIIAAVTATRLADPYPRYREIREVGAFIPGEIADRTVTLVTRLAEASAVLAHPAV
GHGYTDGINYRTGMDDGLGSLLRADPPDHTRLRRLVGRAFTPAVIEALAPEVTSLANVLLDEAIERGEID
AVAAFARPLPLRLISRLLGVPAADEEEFGGWADALTLGLDPHYLLTDEAKAACNRAAVEFDAYFLDLIAR
RRKEPRDDLLSRLVAIHDRGDMLAERELLELCTLLLVAGYETTANLISGGILALTRNPGQLAALRADPAL
VGPAVEEMLRFDPPVQFIARTVLADAEIGGRPFARGDGAIMMIGAANRDPEAFDEPDRFLVARHTRSDRT
RRHLGLGVGIHYCLGAPLARLEAEIAFRALFSRTSSFALAEDTVAYREQIVVRGLKRLPLHLSA
CYP107BF1 Frankia sp. EAN1pec
YP_001505776.1
ABW10870.1
43% to CYP107AT1 Saccharopolyspora erythraea
MSAAPQVVFDAFAPVYRSNPYPRYALVRESTALYPINPQIAMATRYEECSAVLTDALWGHGYEDGINPFR
PGVDPDDVPGSMLRMDPPDHTRMRGLVKRAFVPRHTEGLRPRVEGLVNELIDTAIEAGEVDLMEALARPL
PLTVIGDMLGIPPEDYTAVKKWSLEIVRGTDPDILQSPESLARRPEAMREFEAYFAGLIAQRRKDPRDDL
LSDLCAAQERDSVLSDREMLGLSVGLLIGGYETVSDLIGKGLVALLRNPDQVALWRSNPELAPYAVDELL
RYEPPVQFTHRVALEERELAGRAFARGEGVVVLIAAANRDPAVYSDPERLDITRFAGRSPAPRHLSLSEG
IHYCLGAHLGRLQTQIAVDTLLLRAPGLSLTDDEPVWRDTVAIHGLDTLPIRLRD
CYP107BG1 Frankia alni ACN14a
YP_713424.1
CAJ61857.1
53% to YP_001508234 EAN1pec
43% to CYP107AT2 Saccharopolyspora erythraea
MFPVPQVRGTEGAYEGAGFMTTAEIDGDRVDAHRVVDAHDVFDTAHRIDPYPRYRRLRQAGSPTPVRLGD
AEVTLMSRFSDCAAVLQSQAWGHGNVDRLSPFWDQQASLPGSFIRMDPPDHRRLRTLVNKAFSARMVADL
TPMITSLVDTLVDRALAAGGLDVISGLSAPLAQAMVGQRLLGVPAADAEMLRSWELAIARGTDPDALLSA
EDAARRDSAGANVVAYLQDLVARRKAHPEDDLLSRLVAVEESGEVLTAAEVLGICVLLLVAGMETSINLV
GNGILALLAHPDQLALLRARPELAPSAVEEILRYDTPTQFTMRVALTDTTVGERRFRRGDGAIVLMGSAG
RDTDVFDGGERLDVTRYAEPGRSPRHLGFSLGLHYCLGAPLARLEATTAIRTLVERAPALSLATDELSYQ
PSLIHRGLSSLPVDLSPAAA
CYP107BG2 Frankia sp. EAN1pec
YP_001508234.1
ABW13328.1
43% to CYP107AT2 Saccharopolyspora erythraea
MVAAEVTAGVAAESAPVEFTAFHPTHKADPYAVYQRVREARPLCPFMLGDIPVTVLTRYADCEAVLQSDD
WVHGYDAGISPFRDGAASAPRSFLRMDPPDHTRLRGLVNKAFTPRIVNQMAPGIQALADRLVDGALATGS
IDVIGEYAALIASATLGHLLGVPDDVGASLRGWALAIARGTDPDNLLTEAELVARRQATQDFQAYFEELI
AQRRANPTDDLISRMAAARDRDDALSELELLGVSSLLVVAGMETSINYVGSAVLSLLRHPDQLALLRARP
ELLPSAVEEVLRYDPPTQFTMRTACRRTELAGHTFARGDGVLLVSAAAGRDPAAFTDPDRFDITRYHGPR
PARRHLGFSVGIHFCLGAPLARIEAAAAIGALVRRTTTLELAVDEAELVYLPSLIHRALATLPVRVR
CYP107BH1 Frankia alni ACN14a
YP_713399.1
CAJ61832.1
56% to CYP107BH2 YP_001508236 EAN1pec
45% to CYP107AT2 Saccharopolyspora erythraea
MPNRPPPLQEPAVDLGTDTSSVLAAGPATALTPPAALTVDQAALNIFDPAWHHDTFPNYQVLREAGPFAP
GPLGLRLVTRYREVEAILADSAWSHAEEGAIMHPDSDGSDLPTSFLWMEPPDHTRIRRLVGKAFSARRIE
ALRARVTEVAGGLVDAAIAAGEVDLVEAIAYPLPLTMIAELMGVPVADHAAVRSMSFGLARGLDPDVLLS
QAEIDLRRESAAAFREYFTDLVARRRADPADDLVSALALAEAEGDRLTADEMLSTLVVLLVAGHETTVSL
ISSTFLMLMRHPDQYAALRARPDLAAPAVDELMRYCTPSHLTTRVATRDVEVLGEQFAAGDGVIILLASA
NRDAGRYADPERLDLARYAGGAAVPRHLAFGRGHHYCIGAPMVRLEMELLLRTLARRAPRLTPLVDPPPY
RPNLVVRGIAELPVRIDG
CYP107BH2 Frankia sp. EAN1pec
YP_001508236.1
ABW13330.1
42% to CYP107AT2 Saccharopolyspora erythraea
MTGPATSTPHAVAGAPAVPDAEAVLAQAVIESFDPAWRHDPYPAYGTLRRAGTFLPGPLAGTMLVPGHAE
CAAILADPVWSHAEESELLHPDSDVELPGSFLWMEPPDHTRLRGLVSRAFTPRTIEATRPLARRVVDGLI
DDALAAGELDLIEGLAYPLPLTMICELLGVPISEHPAVRRMSAGIARGLDPDVLLSPAELAARTAAVEEF
REFFGALVTARRADPRDDLISALAQVHAEGDRLTTTELLGTLLILVVAGHETTVNLIGNGVLALLRDPAQ
LDALRRDPGLALPAVEEILRFDAPAQVTTRTARAEVTVAGRTFTPGEAVICMLGSANRDPRAFDRPDEFL
VDRYAGGARVSRHLALGMGLHYCLGAPLVRLEVGEVLRGIATRLTGMTLLADPPPYRPNIVVRGMSSLPV
RVTGRPG
CYP107BH3P Frankia sp. CcI3
YP_481037.1
ABD11308.1
50% to CAJ61856
65% to CYP107BH2 YP_001508236 EAN1pec
55% to CYP107P1 Streptomyces coelicolor C-helix region
MDSAAPSLGAPDWPARSDPEMEPPGHTRLRGLVSKAFTPRTIEGMRPWAEQVVDDLLSRLIQRGLTSLPL
SLTPGGVA
CYP107BJ1 Frankia alni ACN14a
YP_713423.1
CAJ61856.1
73% to CYP107BJ3 YP_001508260 EAN1pec
45% to CYP107AT2 Saccharopolyspora erythraea
MVTVQPASSEAYVPPNESSPEQTGARLLAKLFDPANRHDPYSIYTELRAAGPLHTGPFDLKLANRYADCA
AVLGSQEWGHDREPHQLHPTIPAEAFPASFLWMEPPDHTRLRGLVTKAFTARTVAALRPRIAALVDELLD
NALRQGEFDLIATIAYPLPLTVVCEILGVPAEDHPLVQVWSQALARAFDPDVLMTPEALAERNRAIPEFL
SYFRALVSRRRREATGDDLITQLAAVEEQGDRLTEEELLGTCVTLLIAGHETTVNLVGNGMMALIRHPDQ
VALLRERPELIGPAVDELLRYDSPIHMNTRAAKRELVVGGEVFAPGEGIVALIACANRDPLVYDDPERLD
VTRFHTSKPIARHLSFSLGHHYCLGAPLALLEMELLLAGVLDRVADMELLTDTPPYKPNMLIRGLAELPT
RFHAA
CYP107BJ2 Frankia sp. CcI3
YP_481034.1
ABD11305.1
74% to CAJ61856
76% to YP_001508260 EAN1pec
45% to CYP164A2 Mycobacterium smegmatis
45% to CYP107AT2 Saccharopolyspora erythraea
45% to CYP107AE1 Streptomyces sp.
MAVTTDSVFAGADAGTGVAADHGKPLPDQAPDLLAALFDPANRPNPYPLYARLRAAGRLHETPFGLRVAT
RHDDCVAVLSNQSWGHDQEAHQLHPTLPAEEFPATFLWMEPPDHTRLRGLVSKAFTPGRVADLRPRITAL
VDDLLDTALRAGEFDLIETIAYPLPLTIICEILGVPAADHGIIQIWSQALARAFDPDVLMSPEALAERND
AIPEFLAYFRALVARSRRSGGDDLLSALAAVEEQGDRLTEDELLGTCVTLLIAGHETTVNLVGNGALALL
RNPDQTALLRDEPDLIRPAVDELLRYDSPIHLNTRAATREMTVGGRTFSPGEGVVALIACANRDPEAFDD
PDRLDVRRYVAGSGASRHLSFSLGHHYCLGAPLALLEMEIFLAGFLHRVRSAELLVDSPPYKSNLLIRGL
AELPVRFRG
CYP107BJ3 Frankia sp. EAN1pec
YP_001508260.1
ABW13354.1
47% to CYP107AT2 Saccharopolyspora erythraea
MTTSTVVPTAGTGSSGPAGEESTALLAELFDPATRPDPYPVYSRLREAGALHATPFGLPVATRHADCVAV
LANQDWGHDLEAHQMHPTLPAESFPTTFLWMEPPDHTRLRGLVSKGFTPRSVQLLRPRITALVDELLDNA
LAAGEFDLVETIAYPLPLTVICEILGVPAADHPAVQVWSQALARAFDPDALMSPEALAERNRAIPEFLEY
FGALVERHRREPGDNLISALAQVEEAGDRLTADELLGTCVTLIIAGHETTVNLVGNGMLALLRNPDQLAL
LRAEPELIPAAVEELLRYDSPIHLNTRAAKRELEVAGRVFAPGEGVVALIACANRDPRAYPDPDRLDVRR
FTSSAGGPPARHLSFSLGHHYCLGAPLALLEMELLLAAFVRRVSHAEITDNNPPYKPNLLIRGLAELPVR
FRG
CYP107BJ4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY940 59% to CYP107BJ3
CYP107BK1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9749
42% to CYP107AN1 Bradyrhizobium japonicum USDA 110
CYP107BL1X Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9870
51% to CYP107L1 Streptomyces venezuelae
name changed to CYP107BM3
CYP107BM1 Streptomyces hygroscopicus ATCC 53653
ACEX01000414.1 3915-5168 (+) strand
MSENAMSENATHLTPEQVEDPVRGYADLRTRDELPH
AVLPGLTTPVRLVTRYADVKAALTEPRLIRDRTRIPGDADEAQASDAQDELLEAASAGLP
AEYVKYFAGHLALFDGEEHAHRRAPLTRAFTARRIAALRTFVERTADALVAEAEANGGTD
LLGAFAYPLATQVICELIGVEERDRDQVCSWMRDFAFGDGSRAGEALVALVEYAKELIAR
RRAEPTEDLISALLDGDQLTEDDLIGIVFLLINTGITPPALFLAHAALALLDHPEQAARL
HAAPELLPRAVPELLRYVSIVRIGATLYATEDVDFAGTALRRGESVTVALLAADHDPEEF
GDGAGQLDVGREFGRGDGHLAFGHGAHYCIGAALGRLVTSVVLDRLFVRHDGLRLAVPRA
ELEFGHWPGDGFHLLRLPVRL*
CYP107BM2 Streptomyces sp. C strain C
ACEW01000053.1 15059-16303 (+) strand
MNETVHHLSPDRLQDPATGYAGLGDGDGLPRVVLPGLRTPV
RLVTRYADVKAALTEPRLIRDRTKVPGATDGPDAQDELLAPLGDLPPEYARYVSAHLAFL
DGAEHARLRTPLTRAFTARRVASLRPFVEESAARLIGELAGRKEADLLNEFAYPLATSVI
CELVGVDEADRARVCDWIRDFAYGDGSRMGDGLAGVVEYVKALIARRTAAPADDLISALL
GGAREGGAGALDEEEITAMVFLLINTGITPPALFLAHAVLALLDHPGQLDRLRAEPELLG
RAVPELLRHVTLLRIGATLYATEDFVFAGTGLRRGDSVTVALLAANHDPAVYGEASARLD
VTREAARGRGHLAFGHGAHHCIGAALGSLVTGVVFERLLVRRPVPELAVARGELEFGHWP
GDGFHLLRLPVRL*
CYP107BM3 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee May 24, 2010
Clone name SBI_9870
68% to CYP107BM1 69% to CYP107BM2, 38% to CYP107X3
CYP107BM4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY4225 90% to CYP107BM1
CYP107BN1P Frankia sp. CcI3
YP_483188.1
ABD13459.1
40% to CAJ61641 same as ABD13459
39% to CYP107AH1 Streptomyces peucetius
MQQCLGEAMRSLHDCAVEMVLREREEPGNGALGALTVVRDEDGTGFSDEELVSTVLLTAIAGYESTVVQI
GNGFLAMFRHPEQMEHLKRGRTDIAAAVEEILRYAQSSTGFAGMTYAMADVELGSVTVPAGATVFVSLDS
AARDEAHVDSPQRFELSRGSARHHVTFGSGHHYRA
CYP107BP1P Frankia sp. EAN1pec
YP_001505775.1
ABW10869.1
41% to CYP107AT1 Saccharopolyspora erythraea no heme signature
MPSRDIAAAGYMRSPRAKSTESREILMSVDETTEGCVTDANGNLIAYGATSCMVSQLEPSTDVNVSPPAA
APHTTFDEFHA FDVFDPEHWPNPYPRYAMARKARPLIRTPLGVHLVTRYQDCATILQDNNWSHAHKAELF
HPGVEHVDLPTSFLWMDPPDHTRLRALVSKAFTPRTVANLRPRIEQLVKDLFDAIIEAREVDVISALAYP
LPLTIIAELLGAPAEDHPDLQRWSRALARGFDPEPLLSP GNVTHAPMPPVSSWPTSADWAPGNGVSGTRR
AGKHALSVVNPVSTRRRLVTAGVEETDDWSGWLRERRHDDIPLSQRENPHERAVRSTTNTAGRTSGRKGG
PRSRRTEPGCRYRSACSCSRCRSCCRRCRTTPTSRAEQQIGVGATRR
CYP107BQ1P Frankia alni ACN14a
YP_715801.1
CAJ64277.1
56% to CYP107L3 Streptomyces tubercidicus (N-term lower case only)
MTIRTASQEVPMSPTDPIPLYgpqykrdpyplyrrlratgpvhrvrfpsgvigwlvtgyraahealndhr
lgknHALGTSDALSALIDEEGLRHLDLFSLRDILGDLPYDDKRSSVSRRYGPTSEQLRAEVRSDEDTRRL
YQGITRFLVEDTAEFVGSRSALQRECRQRAYGVIGRSRAWGRLVAEHHPRAVRLSIHPQRRGTSKFGIRL
LESSDAWMTPWHATVLRRADGASELMRRADAQRLGRLVTRDGRPSHFQAHAAV
CYP107BR1 Pseudonocardia autotrophica NBRC 12743
AB456955
vdh gene for vitamin D hydroxylase,
50% to CYP107AF1 Streptomyces collinus
MALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGP
VWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLV
GRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAED
RDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDG
DRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEF
LRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDA
SGGVFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLS
RMPVTMGPRSA
CYP107BR2 Geodermatophilus obscurus DSM 43160
CP001867.1
56% to CYP107BR1
MTAVDASVFEGSFWRDPYPAYERLRAQAPVREVALPRGGTTWLVTRYDDVRAAFTDPRLV
KDHRATLPPEVRAQAPRLPGPFGSMMILLDPPDHTRLRRLVSRAFTARRTAELRPRIEAL
AAALLDAVPETEPVDLLAGYAVPLPMAVICELLGVPDTDRDAFGTWSRALVDDQDDVDEQ
QATAGLAQYLYALVETKRRAPDGALISALVEVSEAGDQLSTEEVVAMGVLLLIAGHETTA
NLIGNAVLGVATDAALREHLLADPQRIPAAVEEFLRWDGPVHNAPLRFAAEDVEYSGTTI
PAGSVVTLSVGAANRDPGRFDRPELLDPDRETGGHLAFGHGLHYCLGAPLARLEGEVALR
SLLDRFPDLRLAVPPEELRHRRSVLVHALETLPVVLRPEAAGSASA
CYP107BS1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE12853707 41% to CYP107P1
CYP107BT1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE323 43% to CYP107AZ1
CYP107BU1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE8042 39% to CYP107L2
CYP107BV1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY941 49% to CYP107BJ3
CYP107BW1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6567
CYP107BX1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR810
39% to CYP107N1
CYP107BY1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR895
42% to CYP107L2
CYP107BZ1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR3274
39% to CYP107AF1
CYP107CA1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR6789
50% to CYP107E2
CYP107CB1 Bacillus clausii KSM K16
GenPept BAD63511
45% to CYP107J3, 60% to CYP107CB2
CYP107CB2 Bacillus lehensis
Ang Swi See
Submitted to nomenclature committee April 15,2013
47% to CYP107J3, 60% to CYP107CB1
CYP107CC1 Lyngbya majuscula (filamentous marine cyanobacterium)
EMBL AAT12284.1
UniProt tr|Q5V8A7|Q5V8A7_9CYAN LtxB OS=Lyngbya majuscula
LtxB Lyngbyatoxin biosynthesis
43% to CYP107E2 Saccharopolyspora erythraea NRRL23338
40% to CYP107E7 SCY603 Streptomyces RK95-74
39% to CYP107E1 Micromosospora griseorubida
40% to CYP107N1 Streptomyces lavendulae
41% to CYP107E4 Actinoplanes sp. ATCC 53771
MTNPFADPSRDYWVLCNAEGQYSLWPTSLEIPEGWQTAFGPESWQNCLDNVEKNWTDMRP
LSLLGQRKCPVPYPFREYVALNMDPIYASLQQRDEMLRISVPYGDDAWLASSYKHVKCVI
QDTRFSRETTKYDEARLTPIPIRTSVLGMDPPDHTRLREALAAALTPSHVEQMKPWITSM
TEQLIDDFVAQGPPADLVEQFALPFTGHITCELMGIPLEDRPQFKAWCDGFSSTSSLTKE
EVEVRMQAMYTYITELVGRRRESPSDDIISKLLQPEDKRLELSEIELIDLATILLLAGYD
STAMELANAIFVLLTHPEQTQLIREQPKLMPQAVQELLRYIPIDAHVTFARYATEDVQVG
NTLVRTGDAILASFPSANHDPAIFEDPHTFNIMRPRKPNFGLGTGIHSCAGKLLAVVELE
IALSVLIRRLPTLRLAIPAEEVPWQPGSLLRSTSKLPAEW
CYP107 fragment Streptomyces noursei
GenEMBL AF071516 CDS complement(85..>519)
putative P450 hydroxylase gene, partial cds.
function="may hydroxylate a macrolide antibiotic polyketide moiety
C-term only 63% to 107A2, 55% to 107A1
WTTPTRWSCSAPSLICLPRHGRNTAHRRTSRSHHPGRARRHPDR
DTLIPARSTVFIAGAAANRDPQKFPNPDTFDITRNTQGHLAFGYGVHHCIGRPLAQME
GEVAITALLRRFPHLHLTTPSQNLTWRRSFLRGLTALPVTLN
108 Family
CYP108A1 Pseudomonas spp.
Swiss P33006 (428 amino acids) PIR S27653 A42971 (428 amino acids)
Also found a PIR cross-reference to EMBL S39894 but could not
retrieve it
Peterson J.A., Lu J.-Y., Geisselsoder J., Graham-Lorence S.,
Carmona C., Witney F., Lorence M.C.
Cytochrome P-450 terp: Isolation and purification of the protein
and sequencing of its operon.
J. Biol. Chem. 267, 14193-14203 (1992)
CYP108A1 Pseudomonas spp.
GenEMBL M91440 (6620bp)
Hasemann,C.A., Ravichandran,K.G., Peterson,J.A. and
Deisenhofer,J.
Crystal structure and refinement of cytochrome P450terp at 2.3A
resolution.
J. Molec. Biol. 236, 1169-1185 (1994)
CYP108B1 Mycobacterium smegmatis
MSMEG1429 TIGR,
71% to CYP108B2 68% to CYP108B3
84% to CYP108B9 Mycobacterium vanbaalenii
72% to CYP108B8 Mycobacterium vanbaalenii
MFLTPVKFSPSEVPD
MSTPVINDAARVLAEPRAYADEPRLHAALAELRSQTPVAYVDVPGYYPFW
AITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIRTLIH
MDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPECDFV
QEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSSAEEL
NAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGEYLNDVDCLSYYV
IVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMPLATEEIIRWSA
PVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEIFENADKFDVGR
DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEFMAT
TFVGGLKHLPIRYSVR
CYP108B2 Mycobacterium smegmatis
MSMEG1428 TIGR
71% to CYP108B1
68% to CYP108B3
87% to CYP108B8 Mycobacterium vanbaalenii
73% to CYP108B9 Mycobacterium vanbaalenii
MSTPTMDDAAKALADPTAYADDARLHEALARLRAENPVAWVDQAPYRPFW
AITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGLRTLIH
MDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGPECDFV
TDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGTTVEEQ
MAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDGELMSDMDTLSYYV
IVASAGHDTTKDAISGGLHALIENPGELARLKADPGLMGTAVEEMIRWST
PVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSGNRDEEVFTDPFRFDVGR
DPNKHLAFGYGVHFCLGAALARMEMNSLFSELLPRLDSIELAGEPELSAT
TFVGGLKHLPIRYSIR
CYP108B3 Mycobacterium smegmatis
MSMEG2261 TIGR
68% to CYP108B1 68% to CYP108B2
73% to CYP108B7 Mycobacterium vanbaalenii
69% to CYP108B8 Mycobacterium vanbaalenii
69% to CYP108B9 Mycobacterium vanbaalenii
MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFW
AITRYADIMAIERANDLFTNSPRPVLMTAEEDEQQAAVGISTLIHMDDPQ
HRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGGECDFVQEITV
NYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALL
EMFQYFTELTASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAA
GHDTTSATISGGMLALLEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAF
MRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH
VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGG
LKHLPVRYALR
CYP108B4 Mycobacterium marinum
No accession number
Tim Stinear
MM3999
72% to 108B3
name changed to CYP108B4
CYP108B4 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 108B4 M. marinum = ortholog
name changed to CYP108B4
CYP108B5 Mycobacterium avium subsp. paratuberculosis K-10.
NP_961305, AAS04688.1,
79% to 108B7, 75% to 108B3
MSTTTMDEAA KLLADPMAYT DEQRLHAALT HLRANAPVSW VEVPNYKPFW AITKHADVMD
IERENMLFTN WPRPVLTTAE GDEMQAAAGV RTLIHMDDPQ HRVVRAIGSD WFRPKAMRAL
KVRVDELAKI YVDKMLAAGP ECDFVQEVAV NYPLYVIMSL LGLPEADFPR MLKLTQELFG
SDDSEFKRGS SNEDQLPALL DMFGYFNGVT AARREHPTED LASAIANARV DGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLQRLRDNL DLMPLATEEM IRWVTPVKEF
MRTAAKDTVV RGVPIAAGES VLLSYVSANR DEDVFDEPFR FDVGRDPNKH LAFGYGVHFC
MGAALARMEV NSFFTELLPR LKSIELTGDP ELVATTFVGG LKHLPVRYSL A
CYP108B6 Mycobacterium flavescens PYR-GCK
ZP_01192125.1, EAS11507.1
92% to 108B7, 74% to 108B3
MSVRVADEAG KVFADPTAYA DEQRLHAAMT HLRANAPVSW VDVEGYNPFW AITKHADIMA
IERDNTVFTN SPRPVLTTAE GDAQHASMGV STLIHMDDPQ HRKVRAIGAD WFRPKAMRAL
KVRVDELAKT FVDQMYDRGG ECDFVQEVAV NFPLYVIMSL LGIPESDFGR MLTYTQELFG
SDDAELQRGT TMEERGLALF DMFTYFNELT ASRRAQPTED LASAIANARI NGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLARLQQAP ELLPLAVEEM IRWVTPVKEF
MRTAQQDTEV RGVPIAAGES VLLSYPSGNR DEDVFTDPFR FDIGRDPNKH VAFGYGVHFC
LGAALARMEI NSFFSELLPR LTSVELAGRP EHIATIFVGG LKHLPIRYSL TR
CYP108B7 Mycobacterium vanbaalenii PYR-1
ZP_01203876.1 EAS24868.1
73% to CYP108B3, 73% to CYP108B9, 70% to CYP108B8
MSVRIADEAARVFADPSAYADEARLHAAMTHLRANAPVSWVEVPGYNPFWAITKHADIMAVERDNLVFTN SPRPVLTTAEGDAQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRVDELAKTFVDQMYERGG ECDFVQEVAVNFPLYVIMSLLGIPESDFQRMLTYTQELFGNDDAELQRGESMEERGLALFDMFTYFNEIT AARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIENPDQLQRLQQNP GLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKH VAFGYGVHFCLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR
CYP108B8 Mycobacterium vanbaalenii PYR-1
ZP_01205329.1, EAS26321.1
87% to 108B2
MSTPTMNQESQEAAKVLADPTAYADDQRLHKALAHLRANDPVAWVDHPPYRPFWAITKHADIMAIERAND LFLSEPRPVLVTAEADDMARAQLEAGFGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKIRVDELAKRY VDKMRDIGPECDFVTEIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGATVEEQMAVLTD FFNYFGALTASRRANPTDDLASAIANGLVDGELMSDVDTLSYYVIVASAGHDTTKDAISGGLHALVENPG ELARLQGDLDLMPTAVEEMIRWSTPVKEFMRTAAEDTTVRGVPIAKGESVYLAYVSANRDEDIFDDPFRF DVGRDPNKHLSFGYGVHFCLGAALARMEINSLFSELLPRLDSIELAGRPELSATTFVGGLKHLPVRYSLR
CYP108B9 Mycobacterium vanbaalenii PYR-1
ZP_01205327.1, EAS26319.1
84% to 108B1
MSTPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNE LWINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIY VDKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITD FFRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQD QLARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKF DVGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR
CYP108B10 Frankia sp. EAN1pec
YP_001507052.1
ABW12146.1
54% to CYP108B8 Mycobacterium vanbaalenii
MDIEAAATVFTDPRAYADNERFHTATALLRRESPIHRIEHPNFHPFWAVTKHEDVMAISRASDIWINEPR
PALGPKPKDAERENIPIRSLVQMDAPDHPVYRHVSADWFKPAGVRRLRDRIAELAKRFVDRMADQGGECD
FFTDIVSHYPLYVILSLLGLPEEDFPRMLRLTQELFGADDEDLARDQDKQAQRAPLVDFFNYFQALIQDR
RENPTDDLGSVIANATIQGEQIGKLEAAGYYTLIATAGHDTTSAALAGGLHALLESPGQWQRLVDDPRMV
ATGVDEMIRWVSPVKHFMRTAREDTVVRGVALAAGESVLLSYPSANRDEDVFENPDTFDVGRSPNRHVAF
GFGAHYCLGTHLARLEGQALYAELVPRVRSIELAGTPEYMEALFVGGPKRLPIRYTMA
CYP108B11 Frankia sp. EAN1pec
YP_001507026.1
ABW12120.1
57% to CYP108B6 Mycobacterium flavescens
MGFRSRALVIDNIPNRRASALGSLPLGSPWRGTHEGGPGMDIAEAATVFTDPTAYADNQRFHTATALLRR
AAPVQRVEHEDFESFYAITKHDDVMTISRGSDIWRNAPRPALGPKPKDGRAAEDAPVRTLIQMDAPDHPV
YRHISAEWFKPLGVRRLAGRIAELAKRYVDTMADFGGACDFFADVACHYPLYVILSLLGLPEDDFPRMLK
LTQELFGANDPDMARGSGDEQALMAALLDFFTYFQALTADRRANPTDDLASVIANATIDGEPIGELEAIG
YYVLIATAGHDTTSSALAGGMHALLQYPDQWRRLSENPGLVPTAFDEMIRWVTPVKQFMRTAARDTEIRG
VPIAAGESVLLSYPSANRDEDVFDNPDTFDVGRTPNRHVAFGFGAHYCLGTHLARLEGQALYAELVPRLR
SIDLAGTPEYMETLFVGGPKRLPIRYTMT
CYP108B12P Frankia sp. EAN1pec
YP_001509055.1
ABW14149.1
67% to CYP108B7 Mycobacterium vanbaalenii PYR-1
MDLDEAGSVFTDPTAYADEKRWHTATALLRRHSPVHRVESAGFAPFWAVTRHEDVFTDPEAFDVGRTPNK
HVGFGFGAHYCLGTHLARLEGRALYTELVPRLREVELAGTPEYMQTLFVGGPKHLPIRYTIT
CYP108C1 Saccharopolyspora spinosa strain NRRL 18395
No accession number
Istvan Molnar
Syngenta Biotechnology, Inc.
47% to CYP108B1 43% to CYP108A1
CYP108D1 Novosphingobium aromaticivorans
GenEMBL NZ_AAAV01000137
16805..18166 gene = Saro1710
47% to 108B1 39% to 108C1
MTNTSRLTKRRRPRRSDGKREGFMDSIPMVPAEVGRAVIDPKSY
GTWEPLLDRFDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKST
VFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRK
IANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDE
DMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEP
MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPGIVEEAIR
WTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANRH
LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRW
KAA
CYP108E1 Ralstonia metallidurans
GenEMBL NZ_AAAI01000348
46192..47481 gene = Reut4024
41% to 108B1 39% to 108A1 48% to 108C1
MTIASDFDTELASHEIYSDPERMHEMFETLRREDPVHWTTAPGH
PPFWAVTKQADVIEVGKHPDVFIASPKSFLMNDVEQRVRIEETAATGGKLVRTMIHMD
DPDHKKYRGLTQSYFMPANIKRLESVIQERARALVGRLIEKGTSEFCSEIAVWYPLQI
VMTLLDVPESEHPYLLKLTQQFLAPKDPTLRRDGPDERGKGAVAKEYFAYFGKMLAER
RAAPLKEDLGSLIAHATVDGEPLPLMEAVSYYVILATAGHDTTSSSMCSGLYYLLTQP
GELDRLRARPELMPSAIEEMFRHGSPVKHFVRTATRDFELRGKKIQAGDEVALMYHSA
SFDEEVFDEPRSFRIDRGPNKHVAFGFGIHACLGQNLARASMRTFFTELLARTESIEV
VGKAEFIASNQVGGMKTLNIRVTPSKQSTTDRIEVAA
CYP108F1X Mycobacterium marinum
No accession number
Tim Stinear
MM3999
46% to 108B1
name changed to CYP108B4
CYP108F1X Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 108B4 M. marinum = ortholog
name changed to CYP108B4
CYP108G1 Caulobacter crescentus CB15
GenEMBL AE005918 GenPept AAK24465
NC_002696 complete genome 2703947..2705221
Complete genome sequence of Caulobacter crescentus
Proc. Natl. Acad. Sci. U.S.A. 98 (7), 4136-4141 (2001)
47% to CYP108A1
formerly 108B1 but this was already assigned to
an M. smegmatis seq. (my error)
1 MTISTDIANT IIDPKAYADG DRIDQAFAHL RREAPLAVAQ PDGFDPFWVV TRHADILEVE
61 RQNELFHNGD RATVVTTIEP DKKVREMMGG SPHLVRSLVQ MDNPDHFAYR KITQGALLPQ
121 NLRALEARIR EIARGFVDRM AEHGDRCDFA RDVAFLYPLH VIMEVLGVPE SDEPRMLKLT
181 QELFGNADPD LNRTGKSVTD VGEGVDSIQS VVMDFMMYFN AITEDRRANP RDDLATLIAN
241 GKINGEPMGH LEAMSYYIIA ATAGHDTTSS TTAGALWALA ENPDQFAKVK ADPSLIPGLI
301 EESIRWVTPV KHFMRTATAD AELGGQKIAK GDWIMLSYPS GNRDEAVFED PFTFRVDRTP
361 NKHVAFGYGA HICLGQHLAR MEMRVLWEEL FARLDHVELD GAPTRMVANF VCGPKSVPIR
421 FKMH
CYP108G2 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
67% to CYP108G1 Caulobacter crescentus AE005918
Ectocarpus sctg_1 159023-157728
CYP108G3 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS63163.1 (protein)
CDS complement(1684831..1686087) locus_tag="Plav_1544"
56% to CYP108G1 Caulobacter crescentus
MTDKTIDNAIVNPKTYAHVDEFHRLFTQLRKEEPVRWTEPDGFRPFWTVSKHADIMEVERQNDKFLNDPR
LTLQTIEVEEEVKKFTGGNSKLIRSLVDMDNPDHRNYRGLTQAWFMPPNLKAISARVEALAEKYIDRLEA
KGGECDFVSDVAVWYPLRVIMTVLGVPAEDEPIMLKLTQELFGSTDPDMKRPDATETVNTVTEFFNYFTA
MTEDRRKNPKDDVASVIANATIDGEPIGHLEAISYYIIVATAGHDTTSSTAAGGLLALMQNPEEFAKLKA
NPEGLLGGAIDEMIRWTTPVKHFFRTAAVDYELRGQKIKAGDNLLMCYWSANRDEEAFDDPFSFKIERSP
NKHLAFGYGAHLCLGQHLAKMEIRALYKELLARLDHIELAGDPAWVEASFVSGLKRLPIRYSMKRKAA
CYP108H1 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
49% to CYP108G1 Caulobacter crescentus CB15 AE005918
Ectocarpus sctg_1 1535540-1536841
CYP108H2 Marine metagenome 1093018949056
AACY022454370
57% to CYP108H1
APPRRGPQQSAEHTETWNRVYKEFEEYYEPVIKDRQTCPREDLASLISNGKIDGCPMEHR
AQISYFIIASTAGHDTTSATLATAISVLAERPEVLEQLKANLELIPAFIEETIRWASPVK
HFLRHATQDYELRGQQIKKGDLMYLSYISGNRDEDLIEDPFEFRIDRKPNRHVAFAFGNH
ICLGQHLARLELKIMLEELLPRLESLQLTGKPKLAISDLVCGPKSVPIQYDFKRTA*
CYP108-un1 Mycobacterium smegmatis
MSMEG4159 TIGR (pseudogene)
47% to 108D1
158 residues. 39% to Msmeg_CYPXXII
LTDHYAMAHPKALNDTPDTAQPGQPQTRNPTTPGDLPPLQFFARTVHAET
SLGGVQFSENQRLVMNLAAANRDPRQFDDPESFDADRPRNPHVAFGGGLH
SCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLMAVISLPVA
FTPERSQT
109 Family
CYP109A1 Bacillus subtilis
GenEMBL M24523 (3187bp)
Lewis,P.J. and Wake,R.G.
DNA and protein sequence conservation at the replication terminus
in Bacillus subtilis 168 and W23
J. Bacteriol. 171, 1402-1408 (1989)
Ahn,K. and Wake,R.G.
A unique open reading frame adjacent to the replication terminus
of the Bacillus subtilis W23 chromosome compared with Bacillus
subtilis 168
unpublished (1990)
Ahn,K.S. and Wake,R.G.
Variations and coding features of the sequence spanning the
replication terminus of Bacillus subtilis 168 and W23 chromosomes
Gene 98, 107-112 (1991)
CYP109A2 Bacillus megaterium DSM319
YP_003597238.1
Elisa Brill
Submitted to nomenclature committee 4/17/2013
57% to CYP109A1
CYP109B1 Bacillus subtilis
GenEMBL AF015825 Z99110
YjiB
also similar to CYP106A, both 106 and 109 are close
together on a tree
CYP109C1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_111
49% to 109B1
CYP109C2 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_8140
69% to 109C1, 43% to 109B1
CYP109D1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_4257
43% to 109C1 39% to 109A1
CYP109E1 Bacillus megaterium DSM319
YP_003599057.1
Elisa Brill
Submitted to nomenclature committee 4/17/2013
46% to CYP109B1, 44% to CYP109A2
110 Family
CYP110A1 Anabaena sp. (a cyanobacterium)
Swiss P29980 (354 amino acids) GenEMBL M38044 (5933bp)
GenEMBL U38537, M13161
Lammers,P.J., McLaughlin,S., Papin,S., Trujillo-Provencio,C. and
Ryncarz,A.J.II.
Developmental rearrangement of cyanobacterial nif genes:
Nucleotide sequence, open reading frames, and cytochrome p-450
homology of the Anabaena sp. strain PCC 7120 nifD element
J. Bacteriol. 172, 6981-6990 (1990)
This sequence was later revised to give a complete P450 sequence
of 448 amino acids.
CYP110A1 Nostoc sp. PCC 7120 same as Anabaena sp. PCC 7120
GenPept BAB73407, C37842 (this entry missing N-term)
NC_003272 complete genome 1708114..1709493
1 aa diff to M38044
1 MLTQLPNPIS VPSWWQLINW IADPIGFQKK YSKKYGNIFS MQLAGIGSFV ILGEPQALQE
61 IFTQDSRFDV GRGNTLAEPL IGRTSLMLMD GDRHRRERKL LMPPFHGERL QAYAQQICLI
121 TNQIASEWQI GQPFVARSAM QKLSLEVIIQ IVFGLADGER YQQIKPLFTD WLNMTDSPLR
181 SSMLFLKSLQ KDWGTWTPWG QMKHKQRSIY DLLQAEIEEK RTKENEQRGD VLSLMMAARD
241 ENGQAMTDEE LKDELLTILF AGHETTATTI AWAFYQILKN VNVQEKLQQE LDRLGANPNP
301 MEIAQLPYLT AVSQETLRMY PVLPTLFPRI TKSSINIAGY QLEPDTTLMA SIYLIHYRED
361 LYPNPQQFRP ERFIERQYSP SEYIPFGGGS RRCLGYALAL LEIKLVIATV LSNYQLALAE
421 DKPVNVQRRG FTLAPDGGVR VIMTGKKSLK FEQSSKIFN
CYP110A2 Anabaena variabilis (a cyanobacterium)
GenEMBL U38478 (1743bp)
Lammers, P.J. and Duran, S.
possible alkane/fatty acid hydroxylase
CYP110B1 Nostoc sp. PCC 7120 Same as Anabaena
GenPept BAB75445, AC2274
NC_003272 complete genome complement(4523158..4524546)
45% to CYP110A2 53% to 110E1 49% to 110D1 47% to 110C1
1 MHLPKGPQTP VFVQVLRWVF SPMSFLEDCA KRYGDIFSVK LAKDVPAIVF LSNPKDIQQI
61 LTNDNNQLDS PGDWNDLFEP LLGKRSVITL SGAEHQRQRQ LLMPPFHGER MRGYSQVITD
121 VTEKVISQHQ IGQPFQVRSV TQAITLRVIM QAVFGLYEGS RAEKLQHLLS DLLEKSSSPF
181 SVALLYFPSL RRDFGPIKFW GEQVQIQQQA DELIYQEIQE RRENPDPSRT DILSLLMDAR
241 DADGQPMTDV ELRDELMTLL VAGHETTATA LAWAMYWIHK LPPVKARLLE ELDSLGDNPD
301 STTIFKLPYL NAVYSETLRI YPVAMLTFAR RVIETMALGG YELPPGTPVL GSIYLTHHRE
361 DLYPEPKKFK PERFLERQFS PYEYLPFGGG TRRCLGLAFA QWEMKLALAK ILTSYELELV
421 NNSVEVRPKR RGLVTGPHRP IEMVIKSQRQ ITSRILETTT VS
CYP110B2 Nostoc punctiforme
NZ_AAAY02000005 GenPept ZP_00111619.1
complement(58895..60277) gene = Npun6097
75% TO 110B1
MKLPKGPQSPAVLQMLRWITSPMSFMETCAKRYGDMFTIRLDSK
SPPLIFVSKPEVLEQILTNDIKGLEAPGDTNLVFESLLGKHSVITISGAEHQRQRQLL
LPPFHGERMRSYSQIISDITEKVISQYQIGQPFNIRSVTQAITLRVIMQAVFGLDEGP
RAEKLQHCLAEMLEKGSSVLSAALLYFPALQRDFGPINFWGKQMRRQQAADKLIYEEI
RERQEQPDPSRTDILSLLMAARDEAGQPMTDEKLRDELMTLLVAGHETTATALAWAFY
WIQKIPTVRQKLLKELDSLGDNPDPSTIFKLPYLNAVCSETLRIYPVAMLTFARVVRT
PLSLGGYELEPGIGVIGSIYLTHHREDLYPEPKQFKPERFLERQFSPYEYLPFGGGAR
RCIGLAFAQLEMKLALAKILSTRELELVDNSEVRPKRRGLVTGQDRPIQMVVTSQRQV
KFPILQTATV
CYP110C1 Nostoc sp. PCC 7120 Same as Anabaena
GenPept BAB76385, AF2391
NC_003272 complete genome 5587079..5588485
48% to CYP110A2 49% to 110E1 47% to 110B1
1 MKYQIQRPNP LKTHPFLQKL QWIADPVEYM KKASLQHPDM FTAEVIGFGD TVVFVSHPQG
61 IQTLFANDRK KLVAVGEANR ILYPLVGNNS MFLLEGVKHK QRRQLLMPSF HGERMREYGH
121 LIRNITENLF SQLQQDVTFS ALTAMREISM QVILQAVFGF YEGERCQQFK HLLPIFLSEL
181 FQSPLASSIL FFPSLQKDLG NLTPWGRFVR QREKIDKLLY AEIAERRQEI NSDRIDILSL
241 LISARDETGD SMSDKELRDE LITLMISGHE TTGTAMAWSL YWILQTPEVF QRLIQELDSL
301 GDSPDPMSIF RLPYLTAVCN ETLRINPVAM LTLPRVVKEP IELLGNRLET STTVVGCIYL
361 THHREDLYPE SKLFKPERFL KREFSQYEFM PFGGGVRGCI GQALAMFEMK IVLATVLSRY
421 QLALADRKPE RPQRQGFTLT PTNGVKMLIT GQHKRQNYSM AASTTFNA
CYP110C2 Nostoc punctiforme
GenPept ZP_00108280.1
GenEMBL NZ_AAAY02000070 complement(34550..35941)
gene = Npun2703
60% to 110C1
1 MQLPNILKSP SLLQKLHWVS DPIGYMENAA QEYPDIFTGK IVGFGDTVVF VNHPQAIQEI
61 LTNDRKKFTA VGELNGILKP LLGDNSVLML ESDRHKRQRQ LVTPSFHGER MQAYGQLICN
121 VSKKIFNQLP LNKPFVARNL TKEISLQVIL QSIFGFYEGE KIQKLRQLLP LLLELFESPL
181 SSSLFLFSFL QQDLGAWSPW GNFLRVREKI DQFLYTEIAE CQQQADPERI DILSLLISCR
241 DEAGQPMTDQ ELRDQLITLI LAGYDTTATA MAWGLYWIHK QPLVCEKLLQ ELDTLGDSPD
301 PMSISRLPYL TAVCNETLRI HPVTMFSFPR VVQEPLELLG HSLEPGTILL PSIYLTHHRE
361 NLYPQSKQFK PERFIERQFS PYEFLPFGGG VRRCMGEALA LFEIKLALAT IVSHYHLALV
421 DQRPEQPQRR GFNLAPGSGV KMVMTDQRAR KESLINMTTT PLS
CYP110C3 Anabaena variabilis ATCC 29413
YP_322498
95% to 110C1
MKYQIKRPNPLKTHPFLQKLQWIADPVEYMEKASLQHRDMFTAEVIGFGDTVVFVSHPQGIQTIFANDRK
KLVAVGEANRILYPLVGNNSMFLLEGVKHKQRRQLLMPSFHGERMREYGHLIRNITETLFSQLQQNVTFS
ALTAMREISMQVILQAVFGFYEGERCQQFKHLLPVFLSELFQSPLASSILFFPFLQKDLGNLTPWGRFVR
QREKIDKLLYEEIAERRQEINSDRIDILSLLISSRDETGNSMSDQELRDELITLMISGHETTGTAMAWSL
YWILQTPEVFQRLIQELDSLGDSPDPMSIFRLPYLTAVCNETLRINPVAMLTLPRVVKEPVELLGNRLES
GTTVVGCIYLTHHREDLYPESKLFQPERFLKREFSQYEFMPFGGGVRGCIGQAIAMFEMKIVLATVLSRY
QFALADGKPERPQRQGFTLTPANGVKMLITGKHQRQNYSTAASTTFTT
CYP110C4 Nodularia spumigena CCY9414
ZP_01629302
MSTPNRLKTPAFFQQLQWVADPVGYMEKAAQQYPDIFTAQVVGFGNNLVFVNHPQAMQEILTNDRKKLFA
GGKENKILQPLLGDYSMIMLDGDRHRKRRQLVMPSFHGDRMRSYGEIISNITEEVWSNLPTDKSFLARNV
TQDITLQVMIQAVFGVYQGERSQQLKKQLELMANIFRSPLSSSMLFFSSLQQDLGAWSPWGKFVRDRQEL
DNLIYTEIAERRQQNLENRIDILSLLMSAEDESGNPMTVQELRDELMTLLFAGYETTATALAWGLYFIQK
HPEVQEKLLQELDTLGDSPDPMSIFRLPYLTAVCNETLRIHPVAMLTFPRTVKEPVEISGYALDPGTILV
GSMYLTHQREDLYPEPKQFKPERFLERQFSPYEFIPFGGGVRRCVGEALAVFELKLVLATILSRYELALT
DDQPEVPRRRGVTLAPGRGVNMMITGQRLA
CYP110C5 Crocosphaera watsonii WH 8501
ZP_00518945
MKTIPTPKTPTLVQQLQWVLNPTGYLQTNHHRYPDLFKAKIIGLGNDIILISNPEIMQYILTHDRQEFTA
PSSLNTLLKPLLGDYSVVMLDGDGHRQRRQLVMPSFHGERLKVYGDLTCRITREAMEKLPENQPFLAREV
MQDISLKVIMEAVFGVTEGERYEELQYRLKELLDLFDSPITSGFLFFPSLQKDLGNWSPWGYFLRQRQAL
DKLIYAEISDRRANPDPERTDILSLLMFAKDEQGESMKDQELRDELITLLMAGHETTASAMAWALYWLHH
IPEIKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRLAQQTVEVGGYTFKPGDIVA
GCLYLTHLREDIYANPKQFNPQRFLDHKYSAYEFIPFGGGSRRCMGEALAKFEMKLVIAIIISEYCLKLA
DTQPEKQQRRGLTLSPKRGVKMILEGKRQPQKARELELSTR
CYP110C6 Cyanothece sp. CCY0110
ZP_01731952
MKTIPGSKTPKLIQQLQWIFNPTKYLKTNHRRYPDIFKAKIIGFGDKMILTSRPEIMQYILTHDRKQFTS
PSGLNAILRPLLGDSSVLMLDGDRHRQRRQLVMPSFHGERLKVYGDLTCRITEEVMAKVPQNQPFLAREI
MQDISLKVIMEAVFGVTEGKRYEQLQDRLKKMLDLFNSPLTSAFLFFPFLQKDLGSWSPWGHFLRQRQAI
DELIYAEISDRKAHPDSDRTDILSLLMSAKDEQGQGMKDQELRDELMTLLTAGHETTASAMAWALYWIHH
TPEVKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRVAQEKVEVAGYTFEPGDMIM
GCMYLTHLREDLYTNPEQFNPQRFVDRQYTPYEFIPFGGGSRRCVGEALAQFEIKLVIATIMSQYCLKLA
DTQPEKQQRRGVTLSPARGVKMILEGKRQPQPVRELELSRQ
CYP110C7 Lyngbya sp. PCC 8106
ZP_01620519
MKTLNSPKTSPLIQRLQWVFNPLEYMETNVKINRDIFNTQVTGGVGLIFVNSPEGMQELLTRDTKEFYAP
GSINEILKPLLGEQSVMLLDGDRHKRQRKLLMPPFHGERMRTYGELILNITQQATAKLKPGQPFIARNAM
QEITLAVILQAVFGIYEGSRYDKLKQLITSLLAVTDSPVSSSLLFFTSLQKDWGAWSPWGRFLRMRQKVD
QLLFAEIEERRQNWDENRTDILNLMMAARDEDGQPMADEELRDELLTLLVAGHETTATAMAWALYWIHRQ
PEVYQKLIQELESLPENADPMTIFRLPYLTAVCNEALRIYPVAMLTFPRVTKEPTQLLGYELEANIGLAG
CIYLLHHREDLYPEPKQFKPERFLERKFSPYEFLPFGSGARQCIGMALAQFEMKLALAQILLDYDLTLLE
KRPVKAARRGVTLSPVGGIKMMMNGKRTPSKSVAIPATV
CYP110D1 Nostoc sp. PCC 7120 Same as Anabaena
GenPept BAB76465, AF2401
NC_003272 complete genome 5678382..5679743
48% to CYP110A1 53% to 110E1, 49% to 110B1
1 MTVTQNLPNG PRIPRLLRLF KFITQPIQYV EDFAKVYGDN FTIWGSGESY FVYFSHPQAL
61 EQIFTNVSCF ESSGGGSPLL ELLLGKNSLI LLEGDRHQRQ RQLLTPPFHG ERMRAYGQTI
121 REITQQVTQA WQMGKPFNIR ASMQEITMRV ILRVVFGVDE GELFQELRQL LTTLLDFMGS
181 PLMSSTFFFS FTQKDYGAWS PWGRMVRLIK KIDQLIYALI AQRRAEFGEN RQDILSLLIS
241 ARYDDGQPMS DVELRDELMT MLVAGHETTA SALTWAFYWI DSVPEVREKL FQELDTLNDD
301 SEPSIIAKLP YLTAVCQETL RFYPIVLNAF FRRTKNPMEI MGYKLPKATL VVPSIYLAHH
361 REEVYPQSKQ FRPERFLEKQ FSPYEYLPFG GGNRRCIGLA FAQYEMKIVL ATILSQFQVS
421 RLSKRPVQPV RRGLTLAAPG GMKMVANKRM RNS
CYP110D2 Nostoc punctiforme
NZ_AAAY02000028 GenPept ZP_00109203.1
52704..54170 gene = Npun3650
68% to 110D1
MNIPLSVTLSNMKSRNNKIQKPSNLQTPMTATYNLPDGPQMPRW
LRTIKFISQPVKYVDDFAKTYGDTFTIRSSRSDNHIVYFSQPQALEEIFTADSRHFEV
GRGNTGLRFLLGDRSFMLVDGDRHQRQRQLLAPPFHGERMRAYGEDIRKITQQVSHEW
KIGKPFNIRESMQEITLRVILRVVFGLNEGELFEELRRSLSDLLDFISSPIMSSAFFF
RFIQKDFGAWSPWGRILLQRQKVDLLIYTLLRERRAQTDQNRQDILSLMMAARYDDGQ
GMSDEELHDELMTLLVAGHETTASALTWAFYWIDHLPEVREKLLQELNTIGVNPDLSS
VAKLPYLTAVCQETLRIYPIAMTAFVRIVKTPITIMGYELREGTAIVPSIYLAHHREE
VYPQSKQFKPERFLERQYSPYEYLPFGGGNRRCIGMAFAQYEMKIVLATVLSEFQVSL
VNKRPVHPVRRGLTVATPAGMRMVATPQVKRANTPALV
CYP110D3 Trichodesmium erythraeum
GenPept ZP_00074554.1 GenEMBL NZ_AABK02000068
complement(10019..11407) gene = Tery3870
54% to 110D1
MTLPDGPSLSPLQRRLRTWKFIFSPLSAIEERYSEYGDIFRTNT
NSLYPFIYFCNPKAIQQIFTADPDTFTSGSINGILKYFVGLNSLLLQDGDRHKRQRKL
LMPPFHGDRMRKYGDLIYNITSNVISQWKIEQPFPIRKSTQEISLKVILAAVFGLDQE
GKSYEKLRVLMSDLLDSMSSPLSSTFLFFNFLRKDWGPWSPWGRFLRKKQELHELIIA
EIQTAKKEGNHRDDILSLLLEARDEAGNAMSDEEIKDELLTMLFAGHETTASALAWAL
YWIDMIPSVGEKLMAELATIPSNSDQVAITKLPYLSAICQETLRIYPIAMNAFPRVVQ
KPIEIMGYQLEPGMVAIVPIYLTHHREDIYPEPKKFKPERFLERQFSPYEYLPFGGGS
RRCIGSAFALFEMKLVLATILSQWELKLLPNQRISPVRRGLTMAPPANMRMVVKPKKS
WQKVSQPILTSG
CYP110D4 Lyngbya sp. PCC 8106
ZP_01620515
MTLPNGPQTPRVLRMMKFVARPLDYLEDYYRRYGDFIRIGKSATPLVYVNHPAAIEKIFTAGSEQFRTGN
AGGVLLFLLGDNSVLMVDGERHERQRKLLMPPFHGERLKTYNQLICEITKEVMSQVKIGQPFRVRTLMQD
ITLRVILKAVFGLTEGERYEQLRHLLSAMMESIGSPLAASLMFFPSLRQDWGEWSPWGRFLRYKQQADEM
IYAEIRERKQQRDFDGDDILTLLMSARDETGKPMNETELRDELVTLLIAGHETTASSLTWALYWTHYLPE
VKDKLCFELANLGENPHLSEIARLPYLTAVCNETLRIYPVTLTSGVRVLKKPLELGGYSFEPGTVLFPCT
YLVHQREDIYPEPKKFKPERFLQRQFSPYEFFPFGGGHRRCIGSAMATLEMKIALATILSDWQLKLPHHK
AYKPVRRGLTLSPPAQLSLVAVNRLN
CYP110D5 Crocosphaera watsonii WH 8501
ZP_00513562
MNLPPTLSQPRLLRLFKLIFYPLDYLEDNYQRYGDIFVAGKSETPFVYISNPQGIQTILTRDKTDFKTGG
GSGFLSTLLGDNSLLFLQGERHRRERKLLMPPFHGERLKSYANLIYSISDKVTDKLQINRSFNVRDIMQE
ITLKVILKAVFGITEGERYQRLQELLKSWLSFFDSPANAILIFFPWLRKNWGNWTPWGRFLQIKAEIQEL
IYTEIRERREQKKYEGTDILTLLMLAKDEEGKPLSDQELHDELITLLIAGHETTASALTWALYWIHFCPD
VEDKLRFHFSNLNNNTDLLDIVKLPYLDAVCKETLRIYPVLLTTFIRVLQTPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSQQFRPERFLERNFSPYEYFPFGGGSRRCIGMELAKMEMKIVLYTILSKHKLKLPSSR
PLKAVRRGLTVAPPSNFKMILSN
CYP110D6 Cyanothece sp. CCY0110
ZP_01726400
MVLPPSISTPRLLRLFKLIFYPLDSLENYYERYGDIFIVGQSETPFVYISNPQGIQEILTKDKTHFRTGG
GSGFLTTFLGNNSLLSLKGEKHQRERKLLTPAFHGERLQSYATLIYSISDEVSEKLEINQSFNVREIMQE
ITLQVILKAVFGIAEGKRYQKLKNLLTSWLSFFDSPINATIIFFPFLQKDWGNWTTWGRFLRIKAQIDDL
IYTEINERRQQKNYQGKDILTLLILARDEDGNPMSDQELHDELITLLIAGHETTASSLTWALYWIHYCPE
VEEKLRSHFSILDKNIDLLNIIKLPYLDAVCSETLRIYPVVVNAFIRVLETPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSKQFRPERFLERQFSPYEYLPFGGGSRRCIGMELAKMEMKIVLFTLLSKYKFKLSSSH
PLKPVRRGLTIAPPNSFKMIITQKLAYT
CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena
GenPept BAB76532, AI2409
NC_003272 complete genome 5753083..5754450
50% to CYP110A2 53% to CYP110B1 53% to 110D1
1 MKLPDSPKIP KFMQLVQWIY QPLQLMEASA KAHGDSFTLW LTNKRPIVFL SNPQAIQELF
61 TTPLEQLDAR GTAQVLQPLL GENSLLLLSG ETHQRQRKLL TPPFHGDRMR AYGDIITNIT
121 KEVISNWQLG KPFSVRDSMQ EITLRVILQA VFGLREGERY TQLQKRLCDI LDLSGSALRS
181 TLSFLPALQI DLGRWSPWGH FLRQREAIDQ LLYAEIQDRR DHPDPSRTDI LSLMMAARDE
241 NGEAMTDVEL RDELMTLLVA GHETTASALT WALYWIHKLP QVREKLLAEL DNFGDNGDVN
301 EITRLPYLTA VCQETLRIYP IAMVTIPRIT KTNLEIGGHQ FAPGTMLVGC IYLMHRRPDL
361 YPQPQEFKPE RFLEKQYSLY EYLPFGGSNR RCVGMAFALY EMKLILATVL ANVDLALVDN
421 YPVKPTRRGV TLAPSGGKWL IATAQHQKIK NPVEV
CYP110E2 Nostoc punctiforme
NZ_AAAY02000088 GenPept ZP_00107327.1
complement(18173..19567) gene = Npun1723
58% TO 110E1 55% TO 110B1
MSLLKLPNGPQTHPWIQMYQWLTNPLEYMEACTKRYGDIFTLKL
GQNFAHQVFISNPQAIQQIFTTDPKQLDSGESAGIKAPLLGQQSLLALDGKPHQRQRK
LLTPPFHGERMLAYGELIREITEQVSSQWQVGETFAVLPSMQAISFQVILKAVFGLED
GPRYKKLNELLIKILNPKIPLLRTVLLIFPSMRQDLGAWSPWGKYLRLRQQIDQLIYA
QIQERKAQPNLSGTDILSLMMAARDEAGEPMTDLELRDELMTLLVAGHETTATSLSWA
LYWIHHRPQVREKLLQELDNLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMSALNRLV
KSPLQIGEYNFEPGTILIPSIYLTHHREDLYPESKQFKPERFLERQFSPYEYLPFGGG
NRRCIGMAFALFEMKLVLATVLSRWQMELADSKPVRPVRKGLLFSPAGGVQMVVKGKR
LQNQPILQTSSSSV
CYP110E3 Trichodesmium erythraeum
GenPept ZP_00072591.1
GenEMBL NZ_AABK02000017 complement(<3..1016)
53% to 110E1 missing C-terminal 121 aa (runs off end of clone)
1 MIKLPGPKSP ALTQILQWTA KPIKFMEKCA REYGDTFEVK LNYPIVFISH PKAIEEIFKA
61 NPKKFDCGSS NKLAQPLLGD YSLLLLDDIP HQRQRKLLMP PFHGKRMQAY GELICNVAQE
121 VASKWEIGQV FSMREFTAEI SLKVILQAVF GLYEGERYSK LEKLLGSLLE SLSSPLKTSM
181 LFFQFLQIDL GPWSPWGNFI KNREEIYELL CAEISERRQK LDPERSDILT MLLLARDEEG
241 EGMSDIELRD ELMTLLIAGH ETTATSLSWA FYWIHHQPEI YQKLSRELET FGDDLNPMTV
301 INLPYMNAVC SETLRIYPVV IIVSPRKTKL PITIMGQT
CYP110E4 Gloeobacter violaceus PCC 7421
GenEMBL AP006578 complement(257348..258724)
gene = gll3063
NC_005125 complete genome complement(3256348..3257724)
locus_tag = gll3063
71% to 110E5 55% to 110E1
MSLPPGPSSPSPFQLMQWIGCPTDYLHTTAARYGDPFTMRVGVF
PPLVMFSDPRAIQQLFTAEAGTFDAGASNVALRPTLGANSLLLLDGERHQQQRRLLTP
PFHGERMRAYGELIRQVTEEVIVRWQPGKPFLVRNAMQRISLAVILQAVFGLHDGTRL
VRLRQALGSMLDAMSSPLSMAMLLMLPEDFGPWSPRARLQAHLGAIDELLYAEIRERR
EHFDAGAGDILGLLLAARDEAGAAMGDAELRDELMTLLVAGHETTATAMAWALYWIHY
LPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVALIASPRVARHTVRI
LERDYEAGTRLAAGIYLAHHRPETYPEPERFRPERFLERTFSPYEFVPFGGGSRRCIG
MAFALYEMKLVIATVLLERDLRLVQPRLLRPVRRGVTLAPPEGLYLVPTGERSASRLL
SRTSTAGQ
CYP110E5 Gloeobacter violaceus PCC 7421
GenEMBL AP006578 complement(258800..260176) gene = gll3064
NC_005125 complete genome complement(3257800..3259176)
locus_tag = gll3064
71% to 110E4 55% to 110E2
MSLPAGPASPPPLQLLQWIGRPTDYLERTARRYGDPFTMRLGLH
SPVTGVFFSSPEAFQQLFNTEPGLFDSGGANASSTFNLLFGTNSLILLDGERHQQQRR
LLTPPFHGERMRSYGELIRTLAEQVTARWNLGTPFQARRSMQRISLGVILKAVFGLHD
GTRYLRVCRLLGNLIDASASPLLFGLRLIFPQDAGPMSPMGQLKAQIDAIDELLYAEI
RERRERPDPRADDILSLLMAARDEAGQGMGDVELRDELMTLLVAGHETTATAMAWALY
WIHRLPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVAMVAFARVPRR
PVRILDREYPAGTFLIPNIYLAHRRPEAYPDPERFRPERFLERTFSPYEFVPFGGGSR
RCIGVAFALYEMKLVLATVLSRVELRLADPRPRLPVRRGLTLAPPEDLHLIPTALRSG
HRDLLPAC
CYP110E6 Anabaena variabilis ATCC 29413
YP_322620
MKLPDSPKIPRFMQLVQWIYQPLQLMEASAKAHGDCFTLWLTNKRPIVFLSNPQAIQELFTTPLEQLDAR
GTAQVLQPLLGENSLLLLSGETHQRQRKLLTPPFHGDRMRAYGDIITNITQEVISKWQLGEPFSVRDSMQ
EITLRVILQAVFGLREGERYTQLQKRLCDILDLSGSALRSTLSFLPALQIDLGSWSPWGHFLRQRAAIDQ
LLYAEIQDRRDHPDPSRTDILSLMMAARDENGEAMTDIELRDELMTLLVAGHETTASALTWALYWIHKLP
QVREKLLAELDNFGDNGDVNEITRLPYLTAVCQETLRIYPIAMVTIPRIVKTTLEIGGHQFAPGTMLVGC
IYLMHRRPDLYPQPQEFKPERFLEKQYSLYEYLPFGGSNRRCVGMAFALYEMKLVLATVLANMDLALVDN
YPVKPTRRGVTLAPSGGKWLIATGQHQKVKSPVEV
CYP110E7 Nodularia spumigena CCY9414
ZP_01631632
MPALQLPDGPKNHPWLQTYRWLTSPLEYMEDCAKNYGDIFTIRVGPLSTPQVFVSNPQAIQQIFSTDPKY
LDSGAAAGFKSPLLGNQSLLSLDGKPHQRQRKLLTPPFHGERMLAYGELIRDISQQVTNKWQVGETVSVL
SSMQAISFQVILKAVFGLAEGPRYEKIKEALIAILNPKKPLLRSMLLMFPSLRRDLGAWSPWGEFLRLRQ
QIDELVYAEIQERKAQLDSSRTDILSLMMATRDEAGEPMTDLELRDELMTLLVAGHETTATALSWALYWI
HHQPQVREKLLQELDTLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMLLLSRLVKSPLQIGEYQFEPGTL
LIPCVYLTHHREDLYPDSQTFKPERFLERQFSNSEFIPFGGGNRRCIGMAFALFEMKLVLATVLSNWQME
LANTQPVLPVRKGLLFGPKGGVQMVVKGRRELS
CYP110F1 Nostoc punctiforme
NZ_AAAY02000005 GenPept ZP_00111618.1
complement(57031..58407) gene = Npun6096
48% TO 110E1 48% TO 110D1
MKILDSLTTPSLLQTLQLIAKPTKTLENYATKYGDIFTMRVMGL
KSPPIVFFSHPQAISDCFAVPAHKLDFKKATHVFKPLFGENSIVFKEARSHQQQRQLL
LPAFHGDNLKSYGQAICQIAEELTQSWTSGTNICIHKLMSKITLEIILQVVFGITHGV
RYQQLKEQLSALLEDVTKPWYSSLFFFPSLQKDLGAWSPWGIFLKRREQIDKLIYAEI
SERRWQNDAMRTDILSLLMSAHDVNGQQMTDEELRDQLVSLLLLGYETTSGVLAWIFY
LIHSHPEVKHRLMQELSTLDNLTNPEAITQLPYLTAVCQETLRIHPIALICTPRMLKE
PVEIMGHKFTSETVLVPCIHLAHRRTDTYPEPEQFRPERFLNQKFSPYEYLPFGGGYR
GCIGAAFSMYELKLVTAIILSRFELSLTDKRPAYPVRRGITIVPSGGVKMVVTKKAKF
KRQTILST
CYP110G1 Trichodesmium erythraeum
GenPept ZP_00074734.1
GenEMBL NZ_AABK02000081 complement(2404..3738)
42% to 110C1
1 MKQVCALKTP LWLQRFNYIT NPVSYWQKAY SSYKDAFYAQ GINFGKPLMV FYTPSAAKQI
61 IENCQGDLTT TSFDSELTAI FGDSSFFILE GTNHKKMRKL LIPALHGKHI KTYGELICNL
121 VNNLIENLPF NQSFSALEIA QEISMQVMIK LLFGNYQQER YQKIKQLMIN MVSLFAANVF
181 GFPLFFKFLQ QDLGLVSPWG NFLQQRRKIQ QLIYQEIAER RNHPNQERTD ILSLLMTAQD
241 EKGNFLNDEE LLGQLLSLLF TGNESTAASI AWSWYEVYRN SKIKEKLLEE INNLGDSPEP
301 LSLFNLPYLS AVCNETLRKY PVTMFMIPRI VKNTTEINGY QLDKGMLVTV GTYILHHRED
361 IYDQPEEFKP ERFIEHRFSS FEFLPFGRGM RGCIGADIAL YQMKLTLATI ISHHRLELTN
421 YGQIFPKRRN TILTPIKLRI IKAC
CYP110H1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_2802
44% to 110E4, 43% to 110E2
CYP110J1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_5885
41% to 110E4 46% to 110H1
CYP110K1 Cyanothece sp. CCY0110
ZP_01731775
MTATIKAKKSNNLAFPQGIKRYGLKGILNLIFRPLPTLEAYRNRYGDIYYSPAFSSFPPFIVVSNSEGVE
ALFTADPDLFNSGTSNAAFQPLLGSQSILQLDGEPHKKRRKLLMPSFHGQRLQTYGEIITNITQSIISHW
QKEDIFSMREVTQEITLSVILQAVFGITQGNNYQSLRKQLGRYLDLFNSPLYTSTLFLPILQKNWGTWTP
WGNFIAQRDKVYELLSQEIDKRTTTKDGEDILTLLLSVIDEEGEHLTKSEVMSELMTLLFAGHETTASAL
AWAFYWIHFHPEIYHNLKDELDTIDLDTDPMEIAKLPYLSAVVSETLRIYPIALFAFSRTLTTSWEFMGY
SLDKGMSLAPCIYLVHHHPDIYPNSKQFKPERFLERQFSPYEFIPFGGSNRRCLGYALALYEMKLVLATV
LKQVNLKLVSSQPILPVRRGFTMSPQGGVKMQVI
CYP110L1 Synechococcus sp. CC9311
YP_731620
MLEAILRPIAYYRRCFFRNSGVVRVRMSPTLPPQQVLISDPSVIKELINEDGGRHITAPGQLNGLLSQVL
GKHSIILLAPATHRQRRKLLTPPFHGERLKAYGQLISSLADQSLIDLNVGDVFDAREQMQGITMRVILTA
VFGLHEGDAFRQLERSLASSISIRSGPLGSLLLFFPFLRRDLGRWSPGGRIKAADAAIRRLLLEQIASRR
RAVERCGEENMSADILSLLLSCKDDEGQGLSDDELHDELLTLLFAGHETTATALTWAFYWIHRNPLVLER
LMNELNGLLDHSDPEAIARLPYLSAVVNEVLRIHPVAMLTFPRRIESAITLGGYAFRSGDVVMACIQAVH
ERPDLYPKPLQFNPERFMNQTYGLHEFLAFGGGSRRCIGAALALYEMKLILAKILLNNQFELTPKSNRWN
KPRRRGFTLGPSIPVKLKMVSLRP
CYP110M1 Lyngbya sp. PCC 8106
ZP_01619763
MRLPDGPRLPALLQTLQIIAQPTQFLERCANQFGDCFTLRVLGFNSPPIVFFSNSEAIEAIFTTDTDKFE
LGKITHVFQPLTGSQSLIMQDGKRHQRLRQLLMPSLHSKQLPAYGQTICNLTLKATQNWSPGDFISIRDY
TSEIALEVILQVVLGLKENRRYFQLKHLIEPYLESVNKPLNSIQFFLPPLQQNLGQKSPWGKFLKQRKKI
DDLIYAEIAERRTKPLGEDVLSLLISAKDEAGQPLTDQELRDQLITLLLLGHDTTASALAWAFYWIHRYP
KIVNQLVEELNSLGENPDPMDIVQLPYLNAVCQETLRIHPIALISQPRVVKESIKIENYQFKPGTILVPC
IHLAHHREQIYPNSKQFNPNRFLEQKFSPYEYLPFGGGNRSCIGMALSLFEMKLILATILLNYQLAFNQS
HVVKPVRRGITIVPSINFRLTVLTRKQAGIASKSVNH
CYP110M2 Synechococcus elongatus PCC 6301
YP_170898
MLPPGPSQLALLQTLRIITQPVSFLLSCADRYGDWFTLRVLGPQSPPVVFVSDPEAILAIFSSLADQLEL
GRIADVFRPLVGNESLIMQNGDRHRQQRQLLMPALQGERLFDYTPAMTAITQAAIAQWPLGQPLDLRRQM
SQISLAVILQVVFGLTPGPRYRDLYQRLDQLLEAITDPLYSLQFFWPALQQDWGNWSPWGRFCRQREAID
ALITAEIQEGRQSQQPRQDVLELLLAARDRDGNPLSDQELRDQLMTLLLLGHETTASALTWAVFWLLRHP
DCLNRLQSELVAIGDNDRAIAKAPYLDAVCREALRLQPIALIAQPRRVASPLSLGGYDFASGTILVPCVL
TAHRRAATYPNPDQFQPNRFLERRFSNGEFLPFGGGQRSCIGMALSLIEMKMVLATLLRQCQIAEVSQRP
VRPARRGITFVPSQDFRIQVQQWHNPSAQTAIASV
CYP110N1 Lyngbya majuscula (filamentous marine cyanobacterium)
EMBL AAY42399.1
UniProt tr|Q1EDA9|Q1EDA9_9CYAN HctG OS=Lyngbya majuscula
http://www.ncbi.nlm.nih.gov/pubmed/18001088
HctG in the hectochlorin biosynthetic gene cluster
54% to CYP110E2 Nostoc punctiforme
53% to CYP110E7 gi|119512554| ZP_01631632 Nodularia spumigena CCY9414
52% to CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena
52% to CYP110E6 gi|75908324| YP_322620 Anabaena variabilis ATCC 29413
53% to CYP110B2 Nostoc punctiforme
51% to CYP110B1 Nostoc sp. PCC 7120 Same as Anabaena
49% to CYP110D4 gi|119486457| ZP_01620515 Lyngbya sp. PCC 8106
47% to CYP110C7 gi|119486461| ZP_01620519 Lyngbya sp. PCC 8106
45% to CYP110M1 gi|119485435| ZP_01619763 Lyngbya sp. PCC 8106
46% to Q1EDA8|Q1EDA8_9CYAN HctH OS=Lyngbya majuscula
MKLPPGPQTPAILQMIEWVFHPSKLMQTCAQRYGDTFTVKVGPNLAPVVFLSDPKAIQKI
FTADLKQFETGKLNKIAQPLIGEYSLMLQDGKYHQRQRRLLMPPFHGERMRRYNKIIDDI
AKQVISQWPEGKPFSIRPSIGKISLELIVECVFGLRKGPRSQHLIQLLTLMAEYTSKPLA
IALVSCKPMQRDFGSWSPWGSFIRLKQQITKLIYDEIGERRSQFDSSRTDILTLLMSARD
EDGMPMTDVELHDQLITFLMGGHDTTTTALVWAFYWIHYLPEVREKLLRELDSLGDDLEE
SNIIKLRYLNAVCSETLRINPISVLTLFRSVKSPLQLMSYQYDPGTILAGCIYLTHRRED
LYPEPEKFKPERFLERQFSFYEYLPFGGGNRRCVGDALAMFVMKRVIATVLREKQLTLVD
RRPVKPVFRGPGLAPSGSMQMVAVTKK
CYP110P1 Lyngbya majuscula (filamentous marine cyanobacterium)
EMBL AAY42400.1
UniProt tr|Q1EDA8|Q1EDA8_9CYAN HctH OS=Lyngbya majuscula
HctH in the hectochlorin biosynthetic gene cluster
48% to CYP110E2 Nostoc punctiforme
47% to CYP110D4 gi|119486457| ZP_01620515 Lyngbya sp. PCC 8106
49% to CYP110E6 gi|75908324| YP_322620 Anabaena variabilis ATCC 29413
49% to CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena
48% to CYP110E7 gi|119512554| ZP_01631632 Nodularia spumigena CCY9414
46% to CYP110 Lyngbya majuscula (marine cyanobacterium)
45% to CYP110C7 gi|119486461| ZP_01620519 Lyngbya sp. PCC 8106
43% to CYP110M1 gi|119485435| ZP_01619763 Lyngbya sp. PCC 8106
MMKFPDGPKTPALLQSINLIVNPLNYLEDCAKRYGDIFTIRFLNYPPTVLVSHPQAMKEI
FTASSQTFNTGEAMKELPTAFTGENALPLLDGDLHKHRKRMLMPAFHGERLRAYSELIYD
LTKQEIEQWTKGEPFHVQASMQDISLKFIIRAIFGVNDEDRFQQFKKTLISLLNLLSDPW
TSIVLYFRALQQDWGSWSLWGRFVRLRQQVDDIIYAEIKRRRDDPALLGEDILSLMMSAR
NEQGELINDVELRDDLMILLLGGHETTSMSMTWALYWIHHFPQVYETLMAELDTLDDYQD
SSAIMKLPYLDAVCHETLRIYPPTILGAYRIAQKPVEIMSHKFEAGTFILPCIYLTHRQE
DLYPEPNHFRPERFLERQFSAYEFVAFGGGSRRCIGYALSLFEMKLILATILTNLKLALP
DNRVIKPVRSAFTVAPSPMYMIRA
111 Family
CYP111A1 Pseudomonas incognita
GenEMBL L23310 (2080bp)
Ropp,J.D., Gunsalus,I.C. and Sligar,S.G.
Cloning and expression of a member of a new cytochrome P-450
family: cytochrome P450lin (CYP111) from Pseudomonas incognita.
J. Bact. 175, 6028-6037 (1993)
CYP111A2 Novosphingobium aromaticivorans
GenEMBL NZ_AAAV01000134
complement(20145..21356) gene = Saro1618
65% to CYP111A1
MLDLKNPDTYQGGVPYAALQDLRAEGPVHWNPESDGAGFWAVLG
HDEIVAVSRQPDLFSSAFENGGHRIFNENQVGLTGAGESAIGIPFISRDPPSHTQYRK
FVMPALSPARLQGIEERIAKRVERLFAQVPLGETVNILPLLTVPLPLLTLAELLGVPA
DLWPDLHRWTDAFVGEDDPDFRQSPEAMQAVLAEFMGFATALFEDRRANPGPDIASLL
ANTEIRGEPAPLRDFIANLILALVGGNETTRNSINHTMIALAENPGQWDILRADPSLM
TAAVKEMVRFASPVIHMRRTAMRDTQLGQQAICKGDKVVIFYPAGNRDPAVFENPDRF
EITRPVRQHLAFGSGAHVCVGSRLAEMQLRLAFAEMARHVRAFEVVGEPSRVRSNFIN
GFKRLEVRLLV
CYP111B1 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS61652.1 (protein)
CDS complement(33622..34875) locus_tag="Plav_0029"
49% to CYP111A1 P450 lin L23310 Pseudomonas incognita
MLRPQAKAIDLNGKPDLKDPDLYLHEQHHEAFRRLRAEEPVYWNPEADGPGFWAVTRYDDIEAVSKNPKL
FSSAKHNGGHRIFNENEIGGNDTDASMISMDPPAHAGYRRMVTPGFVPKRISNMEERIRARVTRLLDAMP
KTGEAEFISAVAAALPIEVLAELFGVPESDGPKLFEWSNATVGEDDPELRVSDEYMQKCIMEMAGYAAGL
WQQRLETPGDDLISMLAHSKIGGEAMNFPTYIGTFILLVVAGNETTRNSISGGLLALSENPGERQKLLDD
PSLIPSAVQEIVRWVSPVLHMRRTATEDTELRGQKIRKGDKVVMWYASGNRDEAQWADPYRFDVARYAAP
GVPAQIGFGVGQHFCLGSRLAELQLTILFEELLRRFPDINVSGPIRRLRSNFIYGIKEMPVSYTPEG
112 Family
CYP112A1 Bradyrhizobium japonicum
GenEMBL L02323 L12971 U12678 (11,715bp)
NC_004463 complete genome 2317922..2319127
Tully,R.E. and Keister,D.L.
Cloning and mutagenesis of a cytochrome P-450 locus from
Bradyrhizobium japonicum that is expressed anaerobically and
symbiotically
Appl. Environ. Microbiol. 59, 4136-4142 (1993)
Note: called BJ-1 see CYP114, CYP115P, CYP117
CYP112A2 Rhizobium sp. NGR234 plasmid pNGR234a
GenEMBL AE000083
NC_000914 complement(233666..234868)
Gene = y4lD
Freiberg,C., Fellay,R., Bairoch,A., Broughton,W.J., Rosenthal,A.
and Perret,X.
Molecular basis of symbiosis between Rhizobium and legumes
Nature 387 (6631), 394-401 (1997)
about 92% identical to 112A1
MPEQPLPTLPMWRVDHIEPSPTMLALRANGPIHNVRFPRGHEGW
WVTGYDEAKAVLSDAAFRPAGMPPAAFTPDCVILGSPGWLVSHEGGEHARLRTIVAPA
FSDRRVKLLAQQVEAIAAQLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDHA
FFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPGDNLLTDLLAAVDR
GEATEEEAIGLAAGMLVAGHESTVAQIEFGLLAMLRHPQQRERLVGNPSLVDKAVEEI
LRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPRHFEDPEIFDIGR
DAKPHLAFSYGPHYCIGMALARLELKVVFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEFPVLW
CYP112A3v1 Mesorhizobium loti
GenPept NP_106888
95% to 112A2 Rhizobium sp. NGR234
1 MSEQPLPTLP MWRVDHIEPS PEMLALRANG PIHHVRFPSG HEGWWVTGYD EAKAALSDAA
61 FRPAGMPPAA FTPDSVILGS PGWLVSHEGG EHARLRTIVA PAFSNRRVKV LAQQVEAIAA
121 QLFETLAAQP QPADLRRHLS FPLPAMVISA LMGVLYEDHA FFAGLSDEVM THQHESGPRS
181 ASRLAWEELR AYIRGKMWDK RQDPGDNLLT DLLAAVEQGN ATEEEAIGLA AGMLVAGHES
241 TVAQIEFGLL AMFRHPQQRE RLVGDPSLVD KAVEEILRMY PPGAGWDGIM RYPRTDVTIA
301 GVHIPAESKV LVGLPATSFD PRHFDDPEIF DIGRDENPHL TFSHGPHYCI GMALARLELK
361 VVVGSIFQRF PALRLAVAPE ELKLRKEIIT GGFEEFPVLW
CYP112A3v2 Mesorhizobium loti
GenEMBL AL672112 complement(85404..86606)
Strain R7A symbiosis island
Gene = msi071
2 DIFFS with CYP112A3v1
CYP112A4 Rhizobium etli symbiotic plasmid p42d
NC_004041 55365..56645
89% to 112A3
gene = cpxP2
MSEQSLPTLPMWRVDHIEPSPEMLALRAKGPIHRVRLPSGHECW
WVTGYDEAKAVLSDAAFLPAGMPPADFTPDSVILGSPGWLVSHEGDEHARLRTIVAPA
FSNSRVKLLTQQVEAITVQLFDTLAVQPQPADLRRHLSFPLPAKVISALMGVPFEEHA
FFAGLSDEVMTHQHESGPRSASGLAWEELRAYIHGKIRGKRQDPGDNLLTDLLAAVDQ
GKATEEEAIGLAAGVLVAGHESTVAQIEFGLLAMFRHPQQRERLVRDPSLVDKAVEEI
LRMYSPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPCHFKDPEVFDIGR
DANPHLAFSYGQHNCIGAALARLELKAIFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEMPVLWCGRPPASQSSHLAAPGAHRSDQPLDR
113A Subfamily
CYP113A1 Saccharopolyspora erythraea
GenEMBL L05776 (1320bp) S51613 U82823 PIR B40634 (412 amino acids)
Stassi,D.L., Donadio,S., Staver,M.J. and Katz,L.
Identification of a Saccharopolyspora erythraea gene
required for the final hydroxylation step in erythromycin
biosynthesis.
J. Bact. 175, 182-189 (1993)
eryK erythromycin C-12 hydroxylase
Note: two different database entries have different start
codons. Neither is ATG.
CYP113A1 Saccharopolyspora erythraea NRRL23338
SACE_0713, se: 778654,779847 (+) STRAND
eryK - erythromycin B/D C-12 hydroxylase
LTTIDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHADVQTVLRDTATFSSDPT
RVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADAGESFD
LVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLT
AYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIV
RTLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNT
WVLSANRDSDAHDDPDRFDPSRKSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF
GRLTVDRDDERLRHFEQIVLGTRHLPVLAGSSPRQSA
113B Subfamily
CYP113B1 Streptomyces fradiae
GenEMBL U08223 (7082bp)
Merson-Davies,L.A. and Cundliffe,E.
Analysis of five tylosin biosynthestic genes from the tylIBA
region of the Streptomyces fradiae genome.
unpublished (1994)
CYP113B2 Streptomyces caelestis
cytochrome P-450 hydroxylase homolog (nidi)
GenEMBL AF016585 CDS complement(1-396) N-term only, 60% to 113B1
MVDSVTGPMELSKDANAKELLDWFSHNRTHHPVFWDEGRQAWQV
FRYDDYLTVSNHPEFFSSDFTEVAPTPPELEMILGPGTIGALDPPAHGPMRKLVSQAF
TPRRMAGQEQRIRVIAEELLDRVRGQKTIA
CYP113B3 Streptomyces mycarofaciens
DQ672719.1
midM gene partial (missing C-term)
MSEAPTVPLELSKEANAQELLGLGSPSTGTHHPVFWDENWACLG
KVFRYDDYLTVSNNPQFFSSDFNEVMPTPPELEMVIGPGTIGALDPPAHGPMRKLVSQ
ALTPRRMARLGPRIRAVTQGLLDAVRGQETIDVVGDLSYALPVIVIAELLGIPSGDRD
VFRGWVDTLLTNEGLGYPSLPDNFSETIAPALKEMTDYLLHQIHAKREAPVDDLICGL
VQAEQDGRKLTDVEIVNIVALLLTAGHVSSSTLLSNLSLVLEENPQALADLRADRELV
TGAVEETLRYRSPFNNIFRFLKEDTDILGPEMKKGQMVIAWSQSANRDPEHFPEPDTF
DIRRSSSSRHMAFGIGIHHCLGAFLARQEGKVVLELML
CYP113C1 Streptomyces virginiae
GenEMBL AB072568 4994..6202
46% to 113A1
gene = visD
MAQQTPPAPPSMADGGKAMLAWLRTMRDEHPVHEDQYGVFHVYR
HSDVLAVTSDPAVFSSDLSRLRPDSSALSEEILSVIDPPLHRKLRSLVSQAFTLRTVA
DLEPRVTELAGRLLEKVEGSEFDLVGDFAYPLPVIVIAELLGVPAEDRELFRGWSDRM
LSMQVDDPLEIQFGDEAGEDYERLVKEPLKEMHAYLQRHVDARRETPGDDLLSRLVTA
EIAGERLTDRQIVEFGALLLMAGHVSTSMLLGNTVLCLEENPETAAALRADRALISGV
IEEVLRMRPPITVAARVTTGEVVVGGVTIPKDRMVMASLLSANHDERHIQDPEVFDPR
RSPNPQLAFGHGIHYCLGGPLARLEGRVALEMLLDRFEDIRVTPGAPYDFHREGLFVP
ARSPLTVRRG
CYP113D1 Saccharopolyspora erythraea NRRL23338
SACE_0229, se: 264665,265870 (-) STRAND
45% to CYP113A1, 49% to 113C1
MSIPADTWGIPASQFWLRGRRPERTVDYDAATGMWNVYGYPEIQHVLSDPRTFSSDTTRL
MPAKVAERTSALSEGSLLQMDPPEHTKLRKLVSHAFTPKVVADLAPRIADLANELLDDVG
DRMEMVEDLAYPLPVIVIAELLGVPGSDRHLFKKWVDALLQRDQQFSLVDESDEQVQQVE
EAIAQVKHLTDYLGEHAAERRRAPREDLLTKLVQAEVDGHRLSDTEVVNFANILLLAGHI
TTTMLLGNTVLCLDTHPRQRDAVRADRSLVPSAIEESLRFFSPFAVLGRVTQREVEVGGQ
TIPQDQMLMLWIAAANRDPRQFADPDVFDVTRDPNPQIAFGRGIHFCVGAPLARLEGKVA
LNILLDRFPHLRTDPDEGPTFLPAPTTTGVRKLPLLLTPSA
CYP113E1 Salinispora tropica (marine actinomycete)
Strop_0603 684254..685447 45% to CYP113D1,
MATVPRLTFADGGVSVLPWFRQMRDDQPVWYDQGTGSWNVFRYADIAQILTDPATFSSDP
GRTMPPELVEEAEGSLVAVDPPRHGRLRALISTAFTPRLVEQLAPRVRSIAERLLDRTFV
DRGPEGEFDAIGDVAYLLPVYVIGELLGLPETDREYLVRTADEFYAISADDPFDGTYMAS
MQSTLDGLGTYMLDQAERRRARPGDDLMSALAHAEIDGEQLNDREIRNFAVLLLTAGHIT
TTALLGNTLLALGERRDVMLRWRHGQVDTADVLEEVLRHRTPFTEVYRFTTTEVTIGNQV
VPGDQLLRLWIASGNRDERQFADPDTFVLGRDSRHLGFGLGIHYCLGASLARMESSVVLE
VLAERTTTLAPAVQGLSYYDAPGIFCLRSLPVSYRRS
CYP113F1 Streptomyces sp. Tu6071
ABB69748
PlaO3
1 MTASEEGTRL ADQSADAATM LAWFRRMRES EPVSHDEEAG VWHVFRHADV ERVLADPGTF
61 SSDFSSFMPA QEDVDRFIKG NLLRKDPPQH RKLRTLVSKA FTPGVVARLA PRIEVIADEL
121 LDAKAGADQL ELVADLASPL PVTVIAELLG IPAEDRPMFG RWADSLVAPE SQTSFIPNED
181 RTKAMAVVMR EMNAYCLEHI RRRRAAPSQD LVSKLVAAEV DGQRLDDDEI IGFVGLLLLA
241 GHITTTALLT NVILCLDEFP DIAAALRADP SALPGAIEEV LRFRTPLAPS MRRTTREVRV
301 GEHTVPAGRI LLAWLASANR DERQFTAPDT FDIHRAPNPH LSLGHGIHFC LGAPLARLEV
361 RIAVEKMLGR WSGITVADGV ECHDARGIVG AKKLPLRLRW A
CYP113F2 Frankia sp. EAN1pec
YP_001504963.1
ABW10057.1
56% to CYP113F1 Streptomyces sp. Tu6071
MSQLTTRPNAVRRSLPDLLRWLDELRRRGQVHRDDRQRCWHVLGHPEAGAVLADHRSFTSDLRGLLPRPE
DMPEYNLQEGSFQEDMELFQRGNFVRLDPPEHHRLRGLASRAFTSRTVAGLAPRIAEVTTELLDATGGRT
RLELIDDLAYPLPVIVIAELLGLPAADRPMFRGWADALFDREVADPDQPLTELAAANTRAAVPVLREMNA
YLLDRIRACRAHPGDDLTGRLVQVEVDGQRLADEEIVGFVGLLLLAGHITTTATLGNAALALDEHPGAAA
ELRAEPELLPATIEEVLRLRTPFPRLVRRAVADTRVGDEVIPAGAVVTVWLTAANRDERVFAEPDRFDPR
RAPNPHIAFGQGIHFCLGAPLARLEARTALGILLDRYSDIAVAADVPVEHRDPWAMVSVNSLPLDVRPR
CYP113G1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_3232
47% to CYP113C1 Streptomyces virginiae
114 Family
CYP114A1 Bradyrhizobium japonicum
GenEMBL L02323 L12971 U12678 (11,715bp)
NC_004463 complete genome 2319222..2320511
Tully,R.E. and Keister,D.L.
Cloning and mutagenesis of a cytochrome P-450 locus from
Bradyrhizobium japonicum that is expressed anaerobically and
symbiotically
Appl. Environ. Microbiol. 59, 4136-4142 (1993)
Note: called BJ-3 see CYP112, CYP115P, CYP117
CYP114A2 Rhizobium sp. NGR234 plasmid pNGR234.
GenEMBL AE000082 CDS comp (9861..11264) gene = y4lC
NC_000914 complement(232170..233573)
cytochrome P450 BJ-3 homolog" 90% to CYP114A1
MDMQETTTACADAFAELASPACIDDPYPFMRWLREHDPVHRAAS
GLFLLSRHADICWALKATGDAFRGPAPGELARYFPRAATSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTMREIDNLRPSIARFVAARLDGMAPALERGEAVDLHRQFALALPMLV
FAELFGMPQDDMFGLAAGIGAILEGLSPHASDPQLAAADAASARMKAYFGDLIQRKCI
DPRHDIVATLVGAHDDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPDQ
RHWLQGDAAGVEAFVEEVLRCDAPAMFSSIPRIAQSDIELSGVVIPKNADVRVLIAAG
NRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQLARVQLAESLPR
IQARFPTLTVAEQPTREPSAFLRTFRALPVRLHAQGDSPRLTSAFLNGQRGVEGGASF
EHGDGERRSATDRRAQP
CYP114A3v1 Mesorhizobium loti
GenPept NP_106889
92% to 114A2
1 MDVQETTAAC RDAFAELASP ACIQDPYTFM RWLREHDPVH RAASGLFLLS RHADIYWALK
61 ATGDVFRGPA PGELARYFPR AETSLSLNLL ASTLAMKEPP THTRLRRLIS RDFTIRQIDN
121 LRPSIARIVA ARLDGMAPAL ERGEAVDLHW EFALAVPILV FAELFGMPQD DMFGLAAGIG
181 AILEGLSPHA SDPQLAEADA ASARVQAYFG DLIQRKRTDP RNDIVSMVVG AHDDDADTLS
241 DAELISMLWG MLLGGFATTA ATIDHAVLAM LAYPEQRHWL QGDAVGVKAF VEEVLRCDAP
301 AMFSSIPRIA QRDIELGGVV IPKNADVRVL IAAGNRDPDA FSDPDRFDPA RFYGTTPGMS
361 TDGKIMLSFG HGIHFCLGAQ LARVQLAESL PRIEARFPTL ALAEQPTREP SAFLRTFRAL
421 PVRLHAQGG
CYP114A3v2 Mesorhizobium loti
GenEMBL AL672112 complement(84020..85309)
Strain R7A symbiosis island
Gene = msi070
10 DIFFS with CYP114A3v1
CYP114A4 Rhizobium etli symbiotic plasmid p42d
NC_004041 56651..58252
90% to 114A3
gene = cpxP3
MDVQDTTAACHDAFAELASPACIQDPYPFMRWLREHDPVHRAAS
GLFLLSRHADIYWAFKATGDAFRGPAPSELARYFPRAASSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTVGQIDNLRPSIARIVAARLDGMAPALERGEAVDLHREFALALPMLV
FAELFGMPQDDVFELSAIVSAILEGLSPHASDPQLAAADVASARVKAYFGDLILRKRA
DPRRDIVSTLVGAHTDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPEE
RHWLQGDAAGVEAFVEEVLRCEAPAMFSSIPRIAQRDIELHGVVIPKDADVRVLIAAG
NRDPDAFADPDRFDPVRFYGTRPGMSSDGKIMLSFGHGIHFCLGAQLARVQLAESLPQ
IQARFPTLALAEQPTREPSAFLRTFRALPVRLHAQAAAEVRVVVDQDLCGTTGQCVLT
LPGTFRQREPDGVAEVCMATVPQALHAAVRLAASQCPVAAIRVIESEAGDDHCTNPGP
TPSPADAERHAAKDLRNPGEHDGTI
115 Family
CYP115A1P Bradyrhizobium japonicum
GenEMBL L02323 L12971 U12678 (11,715bp see 1351-1578)
NC_004463 complete genome 2317600..2317905
Tully,R.E. and Keister,D.L.
Cloning and mutagenesis of a cytochrome P-450 locus from
Bradyrhizobium japonicum that is expressed anaerobically and
symbiotically
Appl. Environ. Microbiol. 59, 4136-4142 (1993)
Note: called BJ-2 see CYP112, CYP114, CYP117
Note: This gene fragment has a perfectly good P450 sequence
of 76 amino
acids that includes the C-terminal up to a stop codon.
This may be a fragment of another intact P450 that was
broken up or
rearranged during cloning. A pseudogene would be expected
to have lost
integrity slowly and the whole gene should fade at about
the same rate.
This fragment is good but no upstream region continues it.
GDADRFDVTRRHNPHLSFGQGPHFCLGAALARLELGCAFPAL
FVRLEHLALTIAAEDVVYMPSYVIRCPQRLPVTFRPSIA
CYP115A2v1 Mesorhizobium loti
GenPept NP_106680 88% to CYP115A1P 39% to 154C1 41% to 154A1
1 MPAAPTQLDR LSSAILRQGG MARVSLPGDV VTWAAARHQT LRQMLSDQRF NKDWRQWRAL
61 QDGEIPEDHP LIGICKVDNM TTAHGADHRR LRGLLSSSFA PSRIALLAPR VEQCVDRLLA
121 EMAQRGGSAD LMSEFAAPLP TNVIAELFGL PDEQREEIVA LTYSLASTSA TAEEVRQTRQ
181 RIPEFFRRLI ALKRGQLGDD LASALIVARD KGELVSDTEL IDMLFMVLSA GFVTTAGVIG
241 NGVLALLTHP QQLHLVRSGQ VPWSQAIEEI LRWGTSAANL PFRYATQDVE IDGCLVRRGD
301 AVLMAFHAAN RDEKAFGPGA NRFDVTRRHN PHLSFGEGPH SCLGAALARL ELRCAFPPLF
361 GRLEDLALTI AAEDVVYMPS YVIRCPQRLP VSFRPSVA
CYP115A2v2 Mesorhizobium loti
GenEMBL AL672113 41375..42607
Strain R7A symbiosis island
Gene = msi159
10 DIFFS with CYP115A2v1
CYP115A3P Rhizobium etli symbiotic plasmid p42d
NC_004041 54883..55296
70% to 115A1P 70% to 115A2
gene = cpxP1 pseudogene C-terminal
ANSYGRPTYGDTDMFDFNRLQNPHLPLGQGPHLCLGAALARLELGSVFPPPFVRPEDLALAIAAE
116 Family
CYP116A1 Rhodococcus erythropolis
GenEMBL U17130 (6458bp)
Nagy,I., Schoofs,G., Compernolle,F., Proost,P., Vanderleyden,J.
And De Mot,R.
Degradation of the thiocarbamate herbicide EPTC (S-ethyl
dipropylcarbamothioate) and biosafening by Rhodococcus sp. NI86/21
involve an inducible cytochrome P-450 system and aldehyde
dehydrogenase.
unpublished
CYP116A2 Saccharopolyspora erythraea NRRL23338
SACE_4562, se: 5100284,5101570 (-) STRAND,
56% to CYP116A1, 53% to CYP116B1
VEELQVDATRVGAGCPISRIAEEFDPFGEAYQQDPAGVLKAAREREPVFYSPELDHWVVT
RYADIKEIFRDTRRFSASNALDPITPLGAKARERLAEYDFAPGPVLVNEDEPLHMRRRRA
LAGPLAADEVAKLEGRIRDLVTRYVDGFAGRGRADLVDDLLWEVPAIVGLLVCGVPDEDI
DRARHYTIKMGSFTWGRPTEEHQVEIADQVGQWWSLSGRLVERLKREGGEGWVPTAIEVH
REDPELVNDNHLQNMMMSGLVAAHETTTNATANALRHLLSNRSSWEALCADPSAIPNAVE
ECLRFSSSVLCWRRKALVDVPVGGVTIPAGARVLLVIGSGNHDDDVFGDPGELDIARSNA
KRHLTFGIGSHACIGAPLARLEMRIILEELTRRLPGMRLVEGQDFGYLRNASFHGPRHLL
VEWEPAGA
CYP116B1 Ralstonia metallidurans
GenEMBL NZ_AAAI01000322
25751..28093 gene = Reut3205
52% to CYP116A1 with C-term. Extension
extension may contain a reductase and a ferredoxin component
MPQTNAPASSGSCPIDHSALRAPNGCPISHQAAAFDPFEDGYQQ
DPPEYVRWSRAQEPVFYSPKLGYWVVTRYDDIKAIFRDNITFSPSIALEKITPTGEAA
NAVLASYGYAMNRTLVNEDEPAHMPRRRALMEPFTPAELAHHEPMVRKLTREYVDRFI
DTGRADLVDEMLWEVPLTVALHFLGVPEEDMDLLRQYSIAHTVNTWGRPKPEEQVAVA
HAVGNFWQLAGRILDKMREDPSGPGWMQYGLRKQRELPEVVTDSYLHSMMMAGIVAAH
ETTANASANAIKLLLQHPDVWREICEDPALIPNAVEECLRHNGSVAAWRRLVTRDTEV
GGMSLAAGSKLLIVTSSANHDEHHFADADLFDIHRDNASDQLTFGYGSHQCMGKNLAR
MEMQIFLEELTSRLPHMRLAGQRFTYVPNTSFRGPEHLWVEWDPARNPERTDPTVLAP
RDAVRIGEPTGGTTGRTLIVERVETAAQGVSRIRLVSPDGRALPRWSPGSHIDIECGH
TGISRQYSLCGDPADTSAFEIAVLREPESRGGSAWIHASLRAGDKLKVRGPRNHFRLD
ETCRRAIFIAGGIGVTPVSAMARRAKELGVDYTFHYCGRSRASMAMIDELRALHGDRV
RIHAADEGQRADLAQVLGAPDANTQIYACGPARMIEALEALCATWPEDSLRVEHFSSK
LGTLDPSREQPFAVELKDSGLTLEVPPDQTLLATLRAANIDVQSDCEEGLCGSCEVRV
LAGEIDHRDVVLTRGERDANNRMMACCSRAAKGGKIVLGL
CYP116B2 Rhodococcus sp. NCIMB 9784
GenEMBL AF459424
66% to 116B1 over full fusion protein length
extension may contain a reductase and a ferredoxin component
MSASVPASAPACPVDHAALAGGCPVSANAAAFDPFGSAYQTDPA
ESLRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNILFSPAIALEKITPVSAEATAT
LARYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESG
KADLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAV
GRFWQYAGTVLEKMRQDPSGHGWMPYGIRKQREMPDVVTDSYLHSMMMAGIVAAHETT
ANASANAFKLLLENRAVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATADTRIGDV
DIPAGAKLLVVNASANHDERHFERPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEM
QIFLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLHRHQ
PVTIGEPAARAVSRTVTVERLDRIADDVLRLVLRDAGGKTLPTWTPGAHIDLDLGALS
RQYSLCGAPDAPSYEIAVHLDPESRGGSRYIHEQLEVGSPLRMRGPRNHFALDPGAEH
YVFVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSE
EGTRIDLAALLAEPAPGVQIYACGPGRLLAGLEDASRNWPDGALHVEHFTSSLAALDP
DVEHAFDLELRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVAVLDGEVD
HRDTVLTKAERAANRQMMTCCSRACGDRLALRL
CYP116B3 Rhodococcus ruber
GenEMBL AY957485
Liu,L., Urlacher,V.B. and Schmid,R.D.
Cloning, expression, and characterization of a
self-sufficient cytochrome P450 monooxygenase from
Rhodococcus ruber DSM 44319
Applied Microbiology and Biotechnology
Published online: 11 April 2006
DOI: 10.1007/s00253-006-0355-0
93% to CYP116B2
MSASVPASACPVDHAALAGGCPVSTNAAAFDPFGPAYQADPAES
LRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNLVFSPAIALEKITPVSEEATATLA
RYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESGKA
DLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAVGR
FWQYAGTVLEKMRQDPSGHGWMPYGIRMQQQMPDVVTDSYLHSMMMAGIVAAHETTAN
ASANAFKLLLENRPVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATTDTRIGDVDI
PAGAKLLVVNASANHDERHFDRPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEMQI
FLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLQRQHPV
TIGEPSTRSVSRTVTVERLDRIVDDVLRVVLRAPAGNALPAWTPGAHIDVDLGALSRQ
YSLCGAPDAPTYEIAVLLDPESRGGSRYVHEQLRVGGSLRIRGPRNHFALDPDAEHYV
FVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSAEG
TRVDLAALLATPVSGTQIYACGPGRLLAGLEDASRHWPDGALHVEHFTSSLTALDPDV
EHAFDLDLRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVTVLEGEVDHR
DTVLTKAERAANRQMMTCCSRACGDRLTLRL
CYP116B4 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
73% to CYP116B3 Rhodococcus ruber
CYP116B5 Acinetobacter radioresistens
No accession number
Gianfranco Gilardi, Daniela Minerdi
Submitted to nomencature committee July 25, 2012
62% to CYP116B2 in P450 part
CYP116C1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha08932
Submitted to nomenclature committee 12/13/04
45% to CYP116A1, and 116B1, 53% to rha10704 CYP116C2
CYP116C2 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha08932
Submitted to nomenclature committee 12/13/04
53% to rha08932 CYP116C1
CYP116D1 Saccharopolyspora erythraea NRRL23338
SACE_2622, se: 2849652,2850875 (+) STRAND
39% to CYP116A1, 43% to 116A2
45% to CYP116C2
MHERFDPLATDYLADPFPILAAIREETPVFYSSELDMWPVTRHEDIKRIFTDYETFSGAI
TQTPVYPLAEEAKDILAAGFHTTPTVSNCDPPKHTRVRAHNVKAFSARRIAVLEPTIRAY
VTEMIDRILHQDRFDIVQEVTFPLPATIVFNLIGFPESDMEMLKGLAINRMAFTWGRSTE
AEQVRIAKNQVDYWQYCTEFVASRLAEPKDDFTSDLIRTHLADPDELSVDEITNVVHALS
FAGHETTTNVSSSMIQRLLTHREQWEELCADPALIPKAIEEGLRFDPSLFTWRRITTKPV
SIGGVEVPAGAKLLLLVGSANHDPAKFPDPEAFNIHRSGAQAHLTFGRGIHSCFGAPLAR
LEMQIMLEELTARMPGLRLVEDQDVQYHVNACFRGPVELWLDNSAHR
117 Family
CYP117A1 Bradyrhizobium japonicum
GenEMBL L02323 L12971 U12678 (11,715bp)
NC_004463 complete genome 2321653..2322996
Tully,R.E. and Keister,D.L.
Cloning and mutagenesis of a cytochrome P-450 locus from
Bradyrhizobium japonicum that is expressed anaerobically and
symbiotically
Appl. Environ. Microbiol. 59, 4136-4142 (1993)
Note: called BJ-4 see CYP112, CYP114, CYP115P
CYP117A2 Rhizobium sp. NGR234 plasmid pNGR234a
GenEMBL AE000082 complement(7357..8700) U00090
NC_000914 complement(229666..231009) gene = y4kV
Freiberg,C., Fellay,R., Bairoch,A., Broughton,W.J., Rosenthal,A.
and Perret,X.
Molecular basis of symbiosis between Rhizobium and legumes
Nature 387 (6631), 394-401 (1997)
about 90% identical to 117A1
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDG
GAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRD
ARAHAARTGLINDMVSAFDRSDDALSDDLLVANIRLLLLAGHDTTASTMAWMVIELAR
QPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPATTLLPRRALQELQL
GQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVC
IGYHLVWLELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS
CYP117A3 Mesorhizobium loti
GenPept NP_106891
NC_002678 complete genome 5191629..5192972
locus_tag = mlr6367
94% to 117A2
1 MDMLLNPLDR RHRLRDDIPV VPGAFPLVGH LPAIVCDLPR LLRRAERTLG SHFWLDFGPA
61 GHLMTCVDPD AFALLRHKDV SSALIEEIAP ELLGGTLVAQ DGGAHRQARD AIKAAFLPKG
121 LTQAGIGNLF APVIQARVQA WRDRGDVTIL RETGDLMLKL IFSLMGIPAQ DLPGWHRKYR
181 QLLQLIVAPP VDLPGLPLRR GRAARDWIDA QLRQFVRDAR AHAARTGLIN DMVSSFDRGD
241 DALSDDVLVA NIRLLLLAGH DTTASTMAWM VIELARQPGL WDALVEEAQR VGAVPTRHAD
301 LAQCPVAEAL FRETLRVHPA TTLLPRRALQ ELQLGQRRIP AGTPLCIPLL HFSTSALLHE
361 APDQFRLARW LQRTEPIRPV DMLQFGTGPH VCIGYHLVWL EMVQFCIALA LTMHKAGVRP
421 RLLSAVEKGR RYFPTAHPSM KIRIGFS
CYP117A3v2 Mesorhizobium loti
GenEMBL AL672112 complement(81551..82888)
Strain R7A symbiosis island
Gene = msi068
2 DIFFS with CYP117A3v1
CYP117A4 Rhizobium etli symbiotic plasmid p42d
NC_004041 59081..60424
85% to 117A2
gene = cpxP4
MDMLLNPLNRWRRLRDDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCLDPDALALLRHKEVSSALIEEMAPDILGGTLVTLDG
SAHRQARDGIKAAFLPRGLTEAGIGELFEPIIRAQVKAWRDRGEVAILPDTRNLMLKL
TFSLMGIPAQDLSEWHRKYRQLLQLMVAPPIDLPGMPLRRGRAARDWIDAQSRQFIRD
ARARAARTGLINDMVSAFDCSDGALSDDVLVANIRLLLLAGHETSASTIAWMVIELAQ
HPELWDALVEEAQRVGAVPTGHEDLAQCPVAEALFRETLRMHPASSLVPRRAMQELQL
GQRRIPSGTHLCIPLLHFSTSPLLHEAPDQFRLGRWLQRTEPIRPVDMLQFGAGPHVC
MGYHLVWLELVQFSIALALTMQEAGVRPRLMSGVEKGRRYYPTAHPSMTVRIGFS
>CYP117B1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_5081
41% to 117A3
118 Family
CYP118P1 Mycobacterium leprae
GenEMBL L04666 (40,123bp)
Smith,D.R.
M. leprae cosmid dna sequence
Unpublished (1992)
Note 15,700 to 17,350 is the region of interest
CYP118P1 Mycobacterium leprae
GenPept CAC31116
NC_002677 547312..547788 locus_tag = ML0447
NC_002677 complement(2562932..2563627) locus_tag = ML2159
(a duplication of the seq.)
putative fatty oxidation complex alpha subunit
Sequence below is from TIGR primary nucleotide sequence for ML2159
CYP118 exact match, 49% to 102C1
4 TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH 183
184 DIAAQTRREIYQNRSDRGIANVSY
258 FGDVVKLRCLRRVVDATLRLWS
VPCYLRQARRD 360
361 TTLGNGTSLFHKGQWVIVLLTAPMPG
WGPDANEFNPDRXXXXXXXXXXXXXXXX 470
520 FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG
YCLSISEAFTLKTVGL 677
CYP118P1/CYP102 PSEUDOGENE Mycobacterium leprae
Combined from fragments 50% TO 102C1
Probable CYP102 pseudogene
RLGSGIVEQRISVLSIIALADPXXXXXXXDETVWENI
XXXXXXRLLMGDELFTXXXXESNWGKAHN
TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH
DIAAQTRREIYQNRSDRGIANVSY
FGDVVKLRCLRRVVDATLRLWS
VPCYLRQARRD
TTLGNGTSLFHKGQWVIVLLTAPMPG
WGPDANEFNPDRVLPEICRKLPYTYIL
FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG
YCLSISEAFTLKTVGL
119 Family
CYP119A1 Sulfolobus acidocaldarius (formerly solfataricus) (an archaebacterium)
CORRECTION: Sulfolobus acidocaldarius (see Rabe et al. 2008)
GenEMBL U51337 (1254bp)
Wright, R.L., Harris, K., Solow, B., White, R.H. and Kennelly, P.J.
Cloning of a potential cytochrome P450 from the Archaeon Sulfolobus
solfataricus.
FEBS. Lett. 384, 235-239 (1996)
Kersten S. Rabe, Kathrin Kiko, and Christof M. Niemeyer
Characterization of the Peroxidase Activityof CYP119, a
Thermostable P450 From Sulfolobus acidocaldarius
ChemBioChem 2008, 9, 420 - 425
DOI: 10.1002/cbic.200700450
CYP119A2 Sulfolobus tokodaii
GenPept BAB66184
64% to CYP119A1 U51337 Sulfolobus solfataricus
1 MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL EMLRSGKVFF
61 DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV TVKLLSELDE EFDVIESFAI
121 PLPILVISKM LGINPDVKKV KDWSDLVALR LGRADEIFSI GRKYLELISF SKKELDSRKG
181 KEIVDLTGKI ANSNLSELEK EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA
241 LKAVEEALRF SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP
301 DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID NEVLNGYRKL
361 VVRVERA
120 Family
CYP120A1 Synechocystis sp. (strain PCC6803) Cyanobacterium
GenEMBL D64003(113064bp)
coding region 62160-63494
Kaneko,T., Tanaka,A., Sato,S., Kotani,H., Sazuka,T., Miyajima,N.,
Sugiura,M. and Tabata,S.
Sequence analysis of the genome of the unicellular cyanobacterium
Synechocystis sp. strain PCC6803. I. sequence features in the 1Mb
region from map positions 64% to 92% of the genome
DNA Res. 2,153-166 (1995)
note: gene slr0574 (previously had incorrect gene identifier here)
NT01NS3472 Nostoc sp. PCC 7120 in TIGR not in Genbank
40% to CYP120 aa 399-443
MEMKIVAAHLLRRYHWEILPNQSLDSVLVPTNQPQDGLRVRFQPL
CYP120A2 Trichodesmium erythraeum
NZ_AABK02000021
complement(1844..2800) gene = Tery2088
318aa (short) 57% to 120A1 (missing N-term 127aa)
MTANYLEKWVEMGTLTWYPEIRNYTFDIASLLFMGSDESSQTKL
VSLFEEWVKGLFSIPLSLPWTRFGKSLRCRQKLLQHIEEIILQRQQQQNLGEDALGIL
LQAQDKEVNGLSLDELKDQILLLLFAGHETLTSAIASFCLLTSQHLDVLTRLRQEQKQ
FSAIEPLTLENLKRMTYLDMVLKEVLRLIPPVGGGFRQVTQDCEFCGYSIPKGWLVQY
QIAKTHQDETLYPDDKNFDPERFAPENAVDKQKVFGYVPFGGGMRECLGKEFARLEMK
IFAVMLLRGYEWELLPEQDLSVVAAPTPYPRDGLKVKFRKVE
CYP120A3 Cyanothece sp. CCY0110
ZP_01730375.1
54% to CYP120A1
MLIFFFYNKSKLIYNFDQKMTNIESQKSVSLPPGETGLPFIGETLSFLFDPDFAKKKKSKYGQIYKTNIF
GNDTVTMIGAEANQFLFRNENKYVVSTWPKSTRVLLGKLSLAVKDGNFHTSRRKLLAQAFQPRALNSYIP
KMTEITQQYVEKWLQTKELTWYPELRKYTFDVACSLLISIDNASQTKLASDFETWCQGLFTLPINLPWTN
FGKALKCRAKLLQEIETIIINRQQQPKHQNDALGILLEAKDEEGNSLTIEELKDQILLLLFAGHETLTSS
LSSFVLLMAQHPNILEKVRTEQENLNITEDITSEKLKEMTYLEEVLKEVLRFIPPVGGGFRKVIEEFEFQ
GYRIPKDWTVQYQIAQTHKESDIFPDYQTFDPERFSPENMADKQKNFGYIPFGGGLRECLGKEFARLEMK
IFASVLVHNCHWQLLPDQDLEMITIPSPRPRDGLKVKITEV
CYP120A4 Lyngbya sp. PCC 8106
ZP_01619745.1
53% to CYP120A1
MTTSEKKQSYPTPPGSLGLPLIGETLSFLRDRDFATKRHQKYGSVFKTNIFGNPTIMMIGTEANQFIFTN
EKKYFENSWPPSTTALLGPASLTIQTGDIHKSRRKLLAQAFQPRVLAGYVPTMEIMTRRYLQKWEQQKTF
AWYPELRKYTFDVACKLFVGDEKASETEMGEWFETWCQGLFTLPLRLPGTKFNKALNCRKKLLNQIETII
RQRQQQAEPGEDALGLLLQAKDEDGNSLSVEELKDQILTLLFAGHETLTSSVTAFCFLLAQHPDVLAKAR
LEQQQIQLTEPLSFEQLKLMSYLDQVLKEVLRFIPPVGGAFREVIETCEFNGYTFPKGWTVLYQIGKTHQ
DNSIYNQPEKFDPDRFSPERTEEKPYGYIPFGGGMRECLGKEFAKLEMKVLATMLLREYEWELLPNQNLE
MTVSPTPHPKDELLVNFKRLSEVH
CYP120A5 Nodularia spumigena CCY941
ZP_01628555.1
53% to CYP120A1
METTNSQTQNKLPLPPGNLGLPLIGETISFLRDPEFAEQRYQQYGPIFKTHLFGQPTIMMIGAEANRFLF
SNENQNFTISWPDSTKTLLGPASLALQTGGTHQKRRKLLSQAFQPRALAGYTSKMEEITHNYLHKWQRMG
TFKWYPELRNYTFDVACKLLIGTDAASDSHFGELFEEWCAGLFTIPINLPWTKFGRALRCRQQLLVKIEE
IILQRQQQPHSDADALGLLLQAEDEDGNRLSLAELKDQVLLLLFAGHETLTSAIASFCLQLAQHPEVLAQ
ALAEQQQLAIEESLTLEHLKQMQYLDQVLKEVLRTIPPVGGGFRRVIQSSEFNGYQIPEGWSVLYQIGKT
HQDSSTYTEPESFDPQRFAPERVEDKQKPFGYVPFGGGVRECLGKEFAKLEMKLFAALLIREYHWELVPG
QNLDLIMVPTPHPRDDLQVNFSTQRGAEGSAKVRGVLDLGGEVAM
CYP120A6 Synechococcus sp.PCC7002
ORF00071
53% to CYP120A1
MTSPSELPLPPGKFGLPVIGETIEFFTDRNFQKKRLEKYGDVFKTSIFTKPTVVMVGAEA
NEVLFRNENKYVKATWPKSTRILLGADSLATQEGGIHSSRRRIIFQAFQPRALESYIPTI
EKITQRYLTQWEQKQEFAWYDELRKYTFDVASTLFIGKDGGAETPLANLFEEWVKGLFSL
PINLPWTAFGKAMKCRRKLLRELEMIIGDRLKTYDANAEPTDALDLLIRAKDEDGNSLSI
DELKDQILLLLFAGHETLTSSLVSFGLLVGQHRDVFEKIRAEQDALDIGNGLDMAVLQQM
TYLDQVFKEVLRLVPPVGGGFREVINTFEYKNFQIPQGWAVQYQIAQTHKDEALYPDHEK
FDPERFSPERLADKQKKFGFIPFGGGMRECIGKEFARLEAKILASMLARDYDWELLPDQD
LSMQVIPTPLPKDGLQIRFYRRQESSSTTA
CYP120B1 Nostoc punctiforme
NZ_AAAY02000018.1
complement(62382..63695) gene = Npun4299
43% TO CYP120A1
MKTNQIPPGSFGLPVLGETLSFVFDRDFAKKRYHQYGPIFKTHL
LGRPTVVMAGPEALEFVLSSHIENFSWREGWPDNFKTLLGESLFLQDGEEHRRNRRLM
MPALHGPALASYFSTMEDITRSYLQKWEKKQEFTWFQEFKQLTFDIASQLFLGTRPGP
ECVRLSQLFTTLTNGLLAINPLPLPFTTFGKAIAARNEILEHLTQVVRERQQNPTQDT
ISLLIKAKDEDGNSLSEKEIIAQAVLLLFAGHETTTSMLTWLCTELACHPEVLEKARV
EQLQLASQGDLDLEQLGKMPYLEQVLWEVERLHQPVGGGFRGVIKDFELNGYHVPTGW
QLYYSIGVTHQIEEIYSEPELFDPDRFSPQRQEHKKYPFSLVGFGGGPRICIGIAFAK
MEMKIVAAHLLRSYHWEILPNQSLEVVAVPTNRPKDGLRVRFQPR
CYP120C1 Nostoc punctiforme
NZ_AAAY02000127.1 GenPept ZP_00106106.1
8154-9512 gene = Npun477
44% to 120B1 36% to CYP120A1
MQQLKSAEEIPGSYGLPILGETLEIFRDSELYLWRRFQQYGSVF
KTSVLGRKRAYLIGPSANRLVLVEQAENMSSRIGWYFLESTFGNNILLQDGEEHRLTR
RLMYPAFHGKAIATYFDTIQNIVQDFLKDWGERGTISLNSSFRQLTLMIATRLFLGSQ
NKSEVEQTSQWFTQLLDSSMAIFKWNVPFTLYGRGQNARGKLVAFLREAIAQRIEQGN
LEESKDVLGLLLAAVDEDGNKLSETQVINEALLLLFAGHETTASLLTWVIFELGNHPE
WRERLRQEQLAVVGNNPLSLSHLKQFPQLTNVLKEAERLYPPVYAYNRGVLKDIEYGG
YRIPAGWFVTISPMLTHRLPELYTEPDRFDPDRFAPPREEDKKHPLALMGFGYGSHSC
LGMEFAQMEMKIVLSTLLRHYDWTVKPDYSAIAPVRQPSKVKDILQAYIEPLLIKHPL
DS
CYP120D1 Cyanothece sp. CCY0110
ZP_01732300.1
48% to CYP120A1
MLFGNSSISVQVGEIHKQRRQILYEVFKPRMLDSYFNTMVKITEKYLDYWMKQENIVWYPEIENYTFDLA
FKFLIGLDKASESSFKPLYEQWQKGIFSLNTIKLPWTKFGKAWKARNLLKKELKEIIIKRQKEQEANDSD
ALDILIKAKDEDGKQLLVDEISDHLLNILFAGYGTLTSTLASFCRLMAQEGEILGKIREEQQRFPKQLTI
MQLKEMPYLDLVLKELLRTNTPVGTGFRQTINNCEINGYHIPKNWFIFYQISNTHKDTDIYQDPDVFDPD
RFGLDRAEGEKPFSYLPFGGGIRECLGKDFARLEMKIFSSLLVRKCQWDLLPNQNLEIEFTPVAKPKDGL
KVKISSY
CYP120E1 Trichodesmium erythraeum IMS101
YP_722428
MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVYQKYGPVYKTNFLGKNFIYFQGYEAIK
FILTNENKYFTYSQILRNYQRIFGENDITVLAGKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKW
IKSDYVDLYSEINNYTLDMILKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFN
QFEQIIVRRKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTSEHLD
VLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDCSFQGFRIPKGWHAYYY
ISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGGARECIGKEFAYLVIKIFISALLDNCSWK
FKENQDLTINTFPVARPAHKIEVCFTPK
121 Family
CYP121A1 Mycobacterium tuberculosis
GenEMBL Z77163 (42861bp) gi 1449344 Rv2276
complement (32358 to 33548)
unpublished
CYP121A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 2526703..2527893
Gene = cyp121 100% match
locus_tag = Mb2299
122 Family
CYP122A1 Streptomyces sp.
GenEMBL U65940( 2500bp)
nearly identical to rapJ gene of St. hygroscopicus involved in
rapamycin biosynthesis
CYP122A2 Streptomyces hygroscopicus
GenEMBL X86780 (107379bp)
coding region 96465-97625
rapJ
CYP122A3 Streptomyces hygroscopicus var.
GenEMBL AF235504 CDS 71460..72626
gene="fkbD"
note="C9 hydroxylase" 89% to 122A1 77% to 122A2
123 Family
CYP123A1 Mycobacterium tuberculosis
GenEMBL Z80226 (34809bp) gi 1550644 Rv0766c
complement (8322-9530)
CYP123A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(861053..862261)
Gene = cyp123 100% match
locus_tag = Mb0789c
CYP123A2 Mycobacterium smegmatis
MSMEG5826 TIGR
pksS
75% to CYP123A1
75% to CYP123A4 Mycobacterium vanbaalenii
40% to CYP275B9
41% to CYP275B6 MSMEG3700
MSLPTVEPVLDPYDYDFHEDPYPYYKRLRDEAPLYRNDERNFWALSRHED
VLKGFRNSTALSNKHGVSLDPVSRNDEAHRVMSFLALDDPAHLRLRTLVS
KGFTPRRIRELEARVTEIAVQHLEIALQSDSFDFVDDFAGKLPMDVISEL
MGVPEEDRVRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRR
RRNVSDDLTSALVEAEIDGDKLTDDEIMAFLFLMVVAGNETTTKLLANAA
YWGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGT
TVPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLG
AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR
CYP123A3 Mycobacterium marinum
No accession number
Tim Stinear
MM4930
72% to 123A1
CYP123A3 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 123A3 M. marinum = ortholog
CYP123A4 Mycobacterium vanbaalenii PYR-1
ZP_01207533.1, EAS23092.1
71% to 123A1
MTISEVRLDPYNYDFHEDPYPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDPA SRGPHASKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTEIAVTHLDAMLEQATTGDAVDYVDEF AGKLPMDVISELMGVPDADRVQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTDDL TSALLEAEIDGDRLTDDEIIGFMFLMVIAGNETTTKLLANAAFWGHRNPDQLTSVYQDLARVPLWVEETL RFDTSSQILARTVSGELTLYDTTIPDGDVVLLLPGSAHRDERVFENPDDYVIGREIGSKLMSFGSGAHFC LGAHLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR
CYP123A5 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05833 and Rha05832
Submitted to nomenclature committee 12/13/04
61% to CYP123A1
formerly CYP123A2 but this was already assigned to
a Mycobacterium smegmatis seq (my error)
CYP123A6 Rhodococcus sp. R04
No accession number
Rui Xue
Submitted to nomenclature committee 5/30/11
77% to CYP123A5 but CYP123A5 has an
error in the I-helix region
CYP123B1 Mycobacterium marinum
No accession number
Tim Stinear
MM4833
45% to 123A1
CYP123B2 Mycobacterium vanbaalenii PYR-1
ZP_01203471.1,EAS24463.1
72% to 123B1
MVSVQIRYDPFDASILNDPYPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPTPP GSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAI LPAAVIADLLGVPATDRDQFRLWSSQLVQVDVNHGQTTDALAAAAAIYAYFTDFLADRRKNPREDLMSAL ANATVDGIGLTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDS PAQGLSRTLTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSEHQVAFGRGIHFCLGAAL ARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV
124 Family
CYP124A1 Mycobacterium tuberculosis
GenEMBL Z77163 (42861bp) gi 1449354 Rv2266
complement (39907-41193)
CYP124A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 2519058..2520344
Gene = cyp124 100% match
locus_tag = Mb2289
CYP124A1 Mycobacterium avium subsp. paratuberculosis str k10
GenEMBL AE017234.1
85% to 124A1 (ortholog)
MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRD
GAFATLRREAPISFWPAIEMDGFVAGNGYWALTKHEDVHFASRHPEIFSSVPNITIND
QTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERARRLVSSLVANH
PNGEAELVSELAGPLPLQVICDMMGIPEEDHQRVFHWTNVILGFGDPDLATDFEEFLQ
VSMDIGAYATALAEDRRVNHHDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETT
RNAISHGVLALSRYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRG
TKMKAGDKVALWYNSANRDESTFGNPWLFDVARTPNPHLGFGGGGAHFCLGANLARRE
IRVVFDELRHEIPDIVATEEPARLLSQFIHGIKRLPVAWTPPR
CYP124A1 Mycobacterium marinum
No accession number
Tim Stinear
MM3361
85% to 124A1 (ortholog)
CYP124A1 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 124A1 M. marinum = ortholog
CYP124A1 Mycobacterium smegmatis
MSMEG3551 TIGR
74% to CYP124A1 M. tuberculosis
44% to CYP268A3
80% to CYP124A1 Mycobacterium vanbaalenii
44% to CYP142B1 Mycobacterium vanbaalenii
note: TIGR seq has 25 extra aa at N-term (lower case).
These my not be real. They do not match other 124A sequences.
formerly 124A2, but all of the CYP124A appear to be orthologs
mpcstadrisagippvgaaalypgg
MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAPISF
HPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIVIGDQTPEL
AEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDSVRDRARRLVAGMV
DRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQIFHWTNVILGFGDP
DLTTDFDEFVTVAMDIGAYATALADQRRSAPADDLTTSLVQAEVDGERLT
SAEVASFFILLVVAGNETTRNAISHGVLALTRYPEQRRLWWSRFDELAPT
AVEEIVRWASPVSYMRRTVTRDTELAGTALPAGSKVTLWYGSANRDETKF
DNPWMFDVQRHPNPHVGFGGGGAHFCLGANLARREITVLFSELHRHLPDI
VATEEPDRLQSAFIHGIKRLPVAWR
CYP124A1 Mycobacterium vanbaalenii PYR-1
ZP_01209134.1,EAS21395.1
72% to 124A1 M. tuberculosis (ortholog)
MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDNEV AGHWALTRHDDVFYASRHPEIFSSALGITVGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAL IEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDPDIA TDFDEFVSVAMGIGAYATQLADDRRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAI SHGVLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA NRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAF
IHGIKRLPVSWSA
CYP124B1 Streptomyces cinnamonensis
GenEMBL AF440781 93981..95273
polyether antibiotic monensin biosynthesis gene cluster
41% to CYP124
gene = monD
MGLTVGPDNAKRGIVPITDSKPAATFPDLVDPSFWARPHAERVA
LFEEMRGLPRPAFIRQNMPGVPWTFGYHALVKYADIVEVSRRPQDFSSNGATTIIGLP
PELDEYYGSMINMDNPEHSRLRRIVSRSFGRNMIPEFEAVATRTARRIIDELIARGPG
DFIRPVAAEMPIAVLSDMMGIPAEDHDFLFDRSNTIVGPLDPDYVPDRADSERAVIEA
SRELGDYIAGLRAERLAAPGNDLITKLVQVQADGEQLTRQELVSFFILLVIAGMETTR
NAISHALVLLTEHPEQKQLLLSDFDTHAPNAVEEILRVSTPINWMRRVATRDCDMNGH
RFRRGDRIFLFYWSGNRDESVFPDPYRFDITRGTNAHVTFGAVGPHVCLGAHLARMEI
TVLYRELLAALPQIHAVGQPRRLDSSFIEGIKHLHCAF
CYP124B2 Streptomyces nanchangensis NS3226
GenEMBL AF521085 complement(100196..101467)
polyether ionophore nanchangmycin biosynthetic gene cluster
41% to CYP124
gene = nanP
MNRGVVSPTEATPASSAKATRPPDFMDPSFWLRPRDERAEVFEK
LRALPGPEFVPPRLPWGPLASGYYALSKHADICEVSRRPQDFSSEGATAILPPEMDEF
YGSMINMDNPEHSRLRRIVARSFGRGMAPKFDAMSRRVARRIVDELIERGPGDFIRPA
AEMPIAVLSTMMGIPGEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDY
IGRLREDRLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQAL
VLLTEHPDQRQLLLSDFELHAKGAVEEILRVGTPINWMRRTATGDCEMNGHRFRKGDE
IFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFCLGAHLARIEIIAMLREL
LASLPDIRVEGEPVRLASSFIEGFKELSCTF
CYP124B2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_3705
99% to CYP124B2 Streptomyces nanchangensis NS3226 only 3 aa diffs
CYP124C1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha04649
Submitted to nomenclature committee 12/13/04
Borderline CYP124
CYP124D1X Mycobacterium avium subsp. paratuberculosis str. k10
GenEMBL AE017241, NP_962752.1, AE016958.1 4266449-4267744
69% to ZP_01204629 CYP124D2 Mycobacterium vanbaalenii
48% to 124E1
renamed CYP125F1 based on clustering on a tree
MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY
RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD
APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE
CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ
YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG
ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER
VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV
LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA
CYP124D2X Mycobacterium vanbaalenii PYR-1
ZP_01204629.1, EAS25621.1
83% to CYP124D3
renamed CYP125F2 based on clustering on a tree
MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA
CYP124D3X Mycobacterium flavescens PYR-GCK
ZP_01194022.1, EAS09632.1
83% to CYP124D2
renamed CYP125F3 based on clustering on a tree
MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT
GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG
YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR
HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD
IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF
FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT
ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG
ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA
CYP124E1X Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_7184
49% to 124D1, 48% to 124D3
44% to 124A1 and 124A2
renamed CYP125E1 based on clustering on a tree
CYP124F1 Frankia alni ACN14a
YP_713586.1
CAJ62021.1
49% to CYP124A1 Mycobacterium avium subsp. paratuberculosis
MSLIADVDLDDLDWWTRPAAERDAYFASVRASGERPYFPELDLAGNTRGRGFYAVTRYADVMEVSRRPED
FCSGEGTNIFDQPLDLREFFGSIIAMDNPQHARQRRIISRGFTAKNLEALRANVGEVTREVLATVAEKGE
CDFVTEVAALIPLRIVNDMMGIPRSQEQFIFESTNKLLGASDPEYVPDQSPRGVAKNLSRVGDDFAELLR
ELAADRQRNPGDDLISLLVAAEGENLTAQELASFFILLVGAGNETTRNAIAHGLLALTQNPDQRALWASD
VDGLTPTAVDEVVRWASPVLHMRRTVTADGVRLGDQEFREGDKLVLWYRSANQDESVFPDGTRFDVRRDL
TPPHLGFGAPGPHFCLGAHLARLELSVVFKALFEYLPDIHAVEEPQFLRTNFLHGIKHLKAAYTPTTVRA
CYP124F2 Frankia alni ACN14a
YP_715440.1
CAJ63908.1
46% to CYP124A1 Mycobacterium avium subsp. paratuberculosis
MPGTRGLPGDVLDDLSWWTRPAAERDATFAWLRAHDPRPYVPELDLTGAPRGGGFWALTRLDDVREVSRR
PADFCSGQGSLIFDQPPRLREFRGSIIDMDNPEHARQRRIVARGFTPKAVAALVEDIARTSREVISAVAR
RGECDFVTEVAALLPLRIVNNLLGIPRSEERFLFEQTNILMGASDPEYVPDQTPRSVARAVHGAGQAMSG
LLEELARDRIRNPQDDLVSSLVAAQEEENLTPTELATFFNLLVGAGNETTRNALAHGLSALTRFPDQREL
WRSDLDRYTPGAVEELLRWASPVLYMRRTVARDGVTLGEQRFDAGDKVVLWYRSANQDEAYFDDATAFRV
TRDPNPHVTFGAPGPHHCLGANLARVELAIAFRTLFELLPDIEATAEPDLLRSNFLHGVKHLPARFTPTA
PRP
CYP124G1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR529
42% to CYP124B1
125 Family
CYP125A1 Mycobacterium tuberculosis
GenEMBL Z82098 (34154bp) gi 1666115 Rv3545c also AD000003
coding region 8135-9436
CYP125A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(3927359..3928660)
Gene = cyp125A1 100% match
locus_tag =Mb3575c
CYP125A2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV5841 57% to CYP125A1 from Mycobacterium tuberculosis
CYP125A3 Mycobacterium smegmatis
MSMEG5951 TIGR
75% to CYP125A1
58% to CYP125A2 67% to CYP125A4 54% to CYP125A5
90% to CYP125A9 Mycobacterium vanbaalenii
70% to CYP125A10 Mycobacterium vanbaalenii
56% to CYP125A11 Mycobacterium vanbaalenii
MPTPNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGD
KGYWLVTKHADVKEVSRRSDVFGSSPDGAIPVWPQDMTREAVDLQRAVLL
NMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAAQGAGDFV
EQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSS
FELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAV
AGNETTRNSITHGMIAFAQNPDQWELYKKERPETAADEIVRWATPVSAFQ
RTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHV
GFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNG
IKHWQVDYTGAGKASVSGAPGTCPVAH
CYP125A4 Mycobacterium smegmatis
MSMEG3526 TIGR
73% to CYP125A1
67% to CYP125A3, 58% to CYP125A5P 57% to 125A2
77% to CYP125A10 Mycobacterium vanbaalenii
67% to Cyp125A9 Mycobacterium vanbaalenii
59% to Cyp125A11 Mycobacterium vanbaalenii
MSDSALHLPAGFDFTDPDIYAERLPVDELAELRRVAPIWWNAQPIGAGGF
DDGGFWVVTKHKDVKEISLRSDVFSSLEKTALPRYPEGTVQDQIEQGRFV
LLNMDAPHHTHLRKIISRAFTPRAVERLRDDLAERARAIVRAAAEEGSGD
FVEQVACELPLQAIAGLMGVPQEDRRKLFDWSNQMVGNQDPEFVANDGAS
AAVELITYGMQLAAQRAAAPGDDLVTKLVQADVEGHKLSDDEFGFFVVLL
AVAGNETTRNSITQGMMAFTDHRDQWELFKRERPVTTADEIVRWATPVTS
FQRTALADTEVSGVRIKKGQRVVMFYRSANFDEDVFTDPYRFDILRDPNP
HVGFGGTGAHYCIGANLARMTIDLIFNAIADEMPDLTPISEPVRLRSGWL
NGIKHWQVDYRGDAAKHRAAQASSQADR
CYP125A5P Mycobacterium smegmatis
MSMEG5819 TIGR
58% to Msmeg_CYPXXXIV 56% to CYP125
54% to MSMEG5951, 56% to 125A1, 58% to MSMEG3526, 54% to MSMEG5951
80% to CYP125A9 Mycobacterium vanbaalenii
59% to CYP125A10 Mycobacterium vanbaalenii
55% to CYP125A11 Mycobacterium vanbaalenii
MATMNTCPFGNGYDFTDPDVLFRGIPVEEFAVLRKTAPVWWNQQGESIFDDGG
YWVISRHEDIKTISRDGGEVWSTNAKGAVMRLPDGVTAEQLDLTKALLIN
HDAPEHTRLRKLVSRLFTPRSVAALEEKLAVAAHDIVAEAKAEGSGNFVE
DIAMKLPLLAIADLIGVPEADREKIFAWSNAIINTDDPDFDSDPTVANAE
LMGYAYTMAEERRRCPADDIVTRLVQADVSGESLGEVEFAFFVILLAVAG
NETTRNAITHGMNAFFENPDQWELFKRERPITAVDEIVRWATPVHCFQRT
AVVDTEIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGF
GGNGAHYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVK
DLQVSYRG*PARLIYYSRMRTHGWSGSAPATD
CYP125A6 Mycobacterium marinum
No accession number
Tim Stinear
MM2783
74% to 125A1
CYP125A6P Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 125A6 M. marinum = ortholog
disrupted by insertion sequence and chromosomal inversion
CYP125A7 Mycobacterium marinum
No accession number
Tim Stinear
MM5032
90% to 125A1
CYP125A7 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 125A7 M. marinum = ortholog
CYP125A8 Streptomyces scabies
SCAB65311
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
84% to CYP125A2
CYP125A9 Mycobacterium vanbaalenii PYR-1
ZP_01208885.1, EAS21554.1
74% to 125A1
MPGPNSCPISPEFDFLDASLNLERLPVEELAELRKSEPVHWVDVPGGTGGFGDRGYWLVTKHADVKEVSK HNEIFGSSPDGAIPVWPQEMTREAIDLQKAVLLNMDAPQHTRLRKIISRGFTPRAVGRLEDELRARAQRI AATAATEGSGDFVEQVSCELPLQAIAELLGVPQEDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELITYA MKMAEERAKNPTEDIVTKLIEADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFSRNPDQWELY KKERPETAADEIVRWATPVSAFQRTALEDTELGGVQIKKGQRVVMSYRSANFDEEVFENPHSFDIMRNPN PHVGFGGTGAHYCIGANLAKMTINLMFNAIADAMPDLKPIGDPERLKSGWLNGIKHWQVDYTGQCPVQH
CYP125A10 Mycobacterium vanbaalenii PYR-1
ZP_01209149.1, EAS21410.1
71% to 125A1
MATPTLPPGFDFTDPDLNLERLPVEELAELRRCAPIWWNEQTSGGAGPFGDGGYWVVTKHRDVKEISKHS EVFSSQQKTALPRYPEGSTTEQVETGSLVLLNMDAPRHTHLRKIISRGFTPRAVERLREDLAQRAHNIAK SAAAAGAGDFVEQVSCELPLQAIAGLLGVPLEDRKKLFDWSNQMVSDDDPEFAHYDNRNAATELIMYAMQ LAALRAEQPGEDIVTKLIEADVDGHKLTDDEFGFFMVLLAVAGNETTRNSITHGMIAFTEHPDQWELFKR ERPATAVDEIVRWATPVTSFQRTALRDYELSGVQIKKGQRVVMSYRSANFDEEVFDDPFTFDIMRDPNPH VGFGGTGAHYCIGANLARMTIDLMFNAIADHLPDLSSAGTPDRLRSGWLNGIKHWQVDYTGPSGCPVAH
CYP125A11 Mycobacterium vanbaalenii PYR-1
ZP_01207525.1, EAS23084.1
57% to 125A1
MTATQSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTAPVWWNEQADSIFDDGGYWVISRHEDVKAISRN STQWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEDRLADAAREIV RSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFHWTNAIMNTDDPEFDADPTMANAELMGYAYS MAEERRRCPADDIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDNPAQWELFKR ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPH LAFGGNGAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR
CYP125A12P Mycobacterium leprae
GenPept CAC30983
NC_002677 2415021..2416227
locus_tag="ML2024
Sequence below is from TIGR primary nucleotide sequence for ML2024
51% to CYP125A1 Rv3545c Z82098 Mycobacterium tuberculosis
1 PGFDFPDPEIYTEQLSV*EPAEMCQAETI**NEQPIGRSGFYDDDY 138
XXXXXXXXXXXXXX
174 HSGTFSNLEKTALACYQEGMNDEQISRGKLVLLNIDASQYTRLHKIISPGFIP*AAEQLR 353
354 DDLXXXXXXXXXXXXXXX 362
410 SGDFVEHVSCELSRQAAIAGLPSG 481
480 VPQEDCKKLFHWSN 521
522 QTVGAQDPKFATNDPMVTSVKLIM*AMQIAADRAKPLGQVIVTNLVEADIEGHKLSKDEFGSF 710
713 VIMLTAAGKENTRNCIMQSMMQFTNFPD*WELYK 814
816 KKAPGTTADKIIRQATLVMS 875
876 FQRTVLK*YELSSVSIKKGQRVVVIYRSANFDEKVLTIRLPCSIMRNPT 1022
1022 PHAGFNDTNVHYCIGIN 1072
1073 LARMTIDRMFHAIAESMPNL*STGKPK*LRSGWLNGVKHWQVD 1201
CYP125A13 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
75% to 125A2 before frameshifted region
clone name SP0266
formerly 125A4 but this name was already assigned to
an M. smegmatis sequence (my error)
CYP125A14P Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05823
Submitted to nomenclature committee 12/13/04
67% to 125A1
formerly 125A5P but this name was already assigned to
an M. smegmatis sequence (my error)
CYP125A15 Salinispora tropica (marine actinomycete)
Strop_2612 complement(2932913..2934139)
66% TO CYP125A14P Rhodococcus sp.
58% to CYP125A1 Rv3545c Z82098 Mycobacterium tuberculosis
60% to CYP125A2 SAV5841 AP005044 Streptomyces avermitilis
MTEPRIPVGFDFTDPAVLERRVPREEFAELRRTAPVWWNVQPRGSAGFDDDGYWVVTRYA
DVMAVSRDSDTYSTRENTAIARFQPGTTRADLEMQRVIMLNVDPPEHTKLRAIVSRGFTP
RAINALRGSLAERAERIVRDAAVRGTGDFVADVACELPLQAIAELIGVPQHHRRKVFDWS
NQLIGYDDPAYGVDPLTAAAELLAYAMEMANERQLNPSDDLVTKLVNAQIDGEHLTTDEF
GFFVMLLAVAGNETTRNAITHGMLAFLEHPEQWELFKAERPRSAVEEIIRWATPVNVFQR
TALVDTTLGGQAISAGQRVALFYGSANFDESVFEEPERFDITRSPNPHLGFGGSGAHFCL
GANLARLEIELIFHSIADHMPDIRKVAEPRRLRSGWINGIREMPVRYR
CYP125A16 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1118
79% to CYP125A2 Streptomyces avermitilis
CYP125A17 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2554 79% to CYP125A2
CYP125A18 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
76% to CYP125A14P Rhodococcus sp. RHA1
note: formerly CYP125A17 but name conflict with another P450
CYP125A19 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR5169
78% to CYP125A2
CYP125B1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05835
Submitted to nomenclature committee 12/13/04
48% to 125D1 44% to 125A5, 44% to 125A2
CYP125B2 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
76% to CYP125B1 Rhodococcus sp. RHA1
CYP125C1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha04272
Submitted to nomenclature committee 12/13/04
47% to 125D1, 44% to 125B1
CYP125D1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05286
Submitted to nomenclature committee 12/13/04
48% to 125B1, 47% to 125C1
CYP125E1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_7184
49% to 124D1, 48% to 124D3
44% to 124A1 and 124A2
renamed CYP125E1 based on clustering on a tree
formerly CYP124E1
CYP125F1 Mycobacterium avium subsp. paratuberculosis str. k10
GenEMBL AE017241, NP_962752.1, AE016958.1 4266449-4267744
69% to ZP_01204629 CYP124D2 Mycobacterium vanbaalenii
48% to 124E1
renamed CYP125F1 based on clustering on a tree
formerly CYP124D1
MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY
RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD
APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE
CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ
YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG
ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER
VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV
LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA
CYP125F2 Mycobacterium vanbaalenii PYR-1
ZP_01204629.1, EAS25621.1
83% to CYP124D3
renamed CYP125F2 based on clustering on a tree
formerly CYP124D2
MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA
CYP125F3 Mycobacterium flavescens PYR-GCK
ZP_01194022.1, EAS09632.1
83% to CYP124D2
renamed CYP125F3 based on clustering on a tree
formerly CYP124D3
MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT
GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG
YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR
HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD
IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF
FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT
ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG
ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA
CYP125G1 Salinispora tropica (marine actinomycete)
Strop_2786 complement(3187819..3189087)
46% TO 125C1 Rhodococcus sp. 45% to 125B1 Rhodococcus sp.
44% to 125E1 Sorangium cellulosum
42% to CYP180A1 SAV2165_geoC AP005029 Streptomyces avermitilis
MSTEVVSTGNRADIAHPATYAAGVPYAEFARLRRDKPVSWVPEAALWRRSGEGRILSQGP
GFWAVTTHEGVVAASRQPEVFSSGRQGAFLADPRTTADLEQARQLLVNMDAPQHARVRKL
VTAVFTPRAIRALGDSVTAHARNLVERAVRQEECDVVADLAAELPLLVLADLLGLPREDR
HLLYQWSNNLVGFDDPEYGGGDVEAYRKTFFEAFQYALSVAGERRRAPREDLMTLLATSE
VDGRRLTDREFCNFWLLLVVAGNETTRHLITGSVLALVDNPMQRERLVADDTLLPSAVDE
LLRWVSPIMQFRRTAIVDTELCGTPIAAGDKVVLWYTSANRDAAVFEAPDELRLHRNPNP
HLSFGMGPHFCLGAHLARLEARTMLRELAPHLSRFRLTGPVVRLESNFVNGVKSLPGSFT
GQ
126 Family
CYP126A1 Mycobacterium tuberculosis
GenEMBL Z80226 (34809bp) gi 1550656 Rv0778
coding region 20888-22132
CYP126A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 873620..874864
Gene = cyp126 100% match
locus_tag = Mb0801
CYP126A2 Mycobacterium smegmatis
MSMEG5812 TIGR
78% to CYP126A1
78% to CYP126A4 Mycobacterium vanbaalenii
44% to CYP124D2 Mycobacterium vanbaalenii
42% to CYP162A
MRADLTDLDNFADGFPHALFEAHRREAPVYWHEPTEHTPDGEGFWSVATY
AETLAVLRDPVTFSSVTGGSRPYGGTLLQDLAIAGQVLNMMDDPRHAQIR
RLVSSGLTPRMIARVEEDLRVRARRLLDAVEPGVPLDFLVEVAAELPMQM
ICILLGVPESERHWLFHAIEPQFDFSGSRTASVGQLTPEEAGNRMYRYGM
ELIAAKRAAPTDDMLSVVANAHDAELSDLELYLFFSLLFSAGAETTRNAV
AGGLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVE
LGGCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFGQGVHY
CLGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA
CYP126A3 Mycobacterium marinum
No accession number
Tim Stinear
MM4915
79% to 126A1
CYP126A3 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 126A3 M. marinum = ortholog
CYP126A4 Mycobacterium vanbaalenii PYR-1
ZP_01207518.1, EAS23077.1
74% to 126A1
MRVAGALAAVDFTDLDNFAAGFPHGLFALHREQAPVYWHEPTENTPDGEGFWSVATHAETLAVFRDPETY SSVTGGERAFGGTLLQDLPIAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLRERARRLLDEVEPG TPVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIEPSFDFGGARKASITRLSVEEAGSRMFEYGQELI AAKRAQPGDDMLSVVVNSGDPQLSDLESYLFFNLLFSAGAETTRNAIAGGLLALIENPDAYRALRADPGL LPTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLG FGQGVHYCLGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR
CYP126A5P Mycobacterium leprae
GenPept CAC31567
NC_002677 complement(1384839..1385327)
locus_tag="ML1185
Sequence below is from TIGR primary nucleotide sequence for ML1185
37% to CYP126 C-terminal
184 DRSLIPSAIEEGSRSETPNWASVTRITIA*LAIGGKTILPNAGVDILMGSANRDGSRWTE 363
364 PNTFDIHWPRQAHTTLAGSHMCLGIGLAQLDTRVMLNNLFD 486
CYP126B1 Saccharopolyspora erythraea NRRL23338
SACE_4143, 4612821,4614128 (-) STRAND,
46% to 126A2 44% to 126A1
VTVDQPELPTSRNASESVSDQLPAVLGGFDLTDQVRFSGGFPHEVFNRLRADEPILLHPP
GRTRDGESFWVLSRYEDVVEAAANPVFSSQGGGSREGGGTHLDDLPAGTYAGGMLNMMDD
PRHQLIKDIVSPAVCPSAVAALEPVVRERASALVSTVLERGTCDLQAEVAGRYSVEVVAA
LLGVPRQDWSRLVDWAEIAMGYEDRDEGEATGRSQAALLDMYKYGCELVRAKRAEPAGDF
MSLIATGEIPEGHGQAPLVDYEREVFFNLISLAGTEPTRNAIAIGLLALVEHPEQWQALR
ADRSLLDGAVEEALRWSSPTPYNRRTATEDIRFRDVLIREGDKVTLWWASANRDERVFAD
PFRFDVRRSPNPHLAFGHGAHTCLGPALARMELRVLLEELLDRVERIELTGPVPWARNSK
HTVALRVPVALTASS
127 Family
CYP127A1 Rhizobium sp.
GenEMBL Z68203(34010bp)
coding region 29431-30675
also AE000101 Rhizobium sp. NGR234
CYP127A2 Rhizobium sp. BR816
No accession number
Ellen Luyten
Submitted to nomenclature committee 4/12/2000
73% identical to CYP127A1
CYP127A3v1 Mesorhizobium loti
GenPept NP_106463
NC_002678 complete genome 4745586..4746803
79% to 127A2
1 MAINPVPDHV PPEMVRDFSL FTSPGMPPTP NGDPHAAVAC AHDGPPIFYS PYNTQDGRGT
61 WVITRAADQR KVLQDTETFS SHRSIFSSIL GETWPTIPLE LDPPAHGAFR SLLSPLLSPK
121 RVTALEPAVR ERAIALIDRI TASATSCDVM KDFAFPFTVS IFLRFLGLPD QGLDTFVGWA
181 KDLLHGDDVE RPVAARKIVA FIDELATNRR KDPVDDLMTF IVQAQIEGRR LTDGEIRGIG
241 VLVFVAGLDT VAAAIGFDLA YLARNLKDQE LLRSEPARIL LATEELLRAY PPIQLIRVAT
301 KDIDFEGAPI RKGDYVSCAT MIANRDPEEF ESPNTVDLAR DHNRHAAFGY GPHRCLGSHL
361 ARREIVIGLE EWLARIPTFR IKEGTAPITC GGHVFGIENL ILDWS
CYP127A3v2 Mesorhizobium loti
GenEMBL AL672114 complement(100678..101895)
Strain R7A symbiosis island
Gene = msi332
2 DIFFS with CYP127A3v1
CYP127A4 Rhizobium etli symbiotic plasmid p42d
NC_004041 97484..98974
81% to 127A2
gene = cpxA5
MHLCSERIYRKRGTRENPMSTGRAGEASKKFRLRPTKQRGFRAA
RRSDRCIACHWRLALLRLEIWRSTILLAPSPRRIRSRRRGFDDRRKAVATIRVPEHVP
PEMVKDFSLFTSPGMERMPNGDPHAAVACLHNGPRIFYSPCNTRDGRGTWVIVRAQDQ
RKLLQDTGTFSSHRSLFASALGENWPLIPLELDPPAHSVFRSLLNPLLSPRRIMELEP
AVRDRAIALISKISASSTSCDILTDFAFPFAVSIFLRLLGLSDERLNTFVGWGKDLLH
GDGIRRTAAARTILAFIDELAAMRRKEPADDFMTFVVQAKVDGRLLRDQEIHGIGVLL
FVAGLDTVATAIGFDLAYLARNPTEQELLRSKPDRIVLAAEELLRAYSTVQMIRVATK
DINFEGAPIRKGDYISCATMIANRDPVEFENPNTIDLAREDNRHTAFAYGPHRCLGSH
LARREIIIGLEEWLSRIPDFRIKDGTAPITYGGHVFGMENLILDWS
128 Family
CYP128A1 Mycobacterium tuberculosis
GenEMBL Z77163 (42861bp) gi 1449352 Rv2268c
coding region 37021-38490
CYP128A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(2521761..2523230)
Gene = cyp128 100% match
locus_tag = Mb2291c
129 Family
CYP129A1 Steptomyces sp.
GenEMBL U50973(3196bp)
Dickens,M.L. and Strohl,W.R.
Isolation and characterization of a gene from Streptomyces sp.
strain C5 that confers the ability to convert daunomycin to
doxorubicin on Streptomyces lividans TK24
J. Bacteriol. 178, 3389-3395 (1996)
gene name doxA
CYP129A2 Streptomyces peucetius
GenEMBL U77891 CDS comp (83..1330)
gene="doxA"
product="daunorubicin C-14 hydroxylase" 94% to 129A1
130 Family
CYP130A1 Mycobacterium tuberculosis
GenEMBL Z77137 (36096bp) gi 1480330 Rv1256c
coding region 30691-31908 cy50.26
CYP130A1X Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome
CYP130 lies in a deletion in M. bovis
CYP130A2 Mycobacterium smegmatis
MSMEG5026 TIGR
77% to CYP130A1
MSHPAVAFELANADTWADPWDMYTALRDHDPVHHVVPPERPHHDYF
VLSRHADIWAAARDHETYSSAQGLTVNYGELELIGLADNPPFVMQDPPTH
TEFRKLVSRGFTPRQVEAVEPQVREFVVERLERLRAEGGGDIVAELFKPL
PSMVVAHYLGVPEADRAQFDGWTEAIVAANSEAGSALGAGDAVMSMTGYF
AELIERRRREPGDDTISHLVAAGADDEAVDVLSILAFTFTMVTGGNDTTT
GMLGGAVQLLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATR
DVTIGDTTIPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSH
GAHFCLGAAAARMQSRVALTELLTRCPDFTVDLDAVVWAGGSYVRRPLSV
PFRAGA
CYP130A3 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha08652
Submitted to nomenclature committee 12/13/04
69% to 130A1
CYP130A4 Mycobacterium marinum
No accession number
Tim Stinear
MM4184
86% to 130A1
CYP130A4P Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 130A4 M. marinum = ortholog
CYP130A5 Mycobacterium vanbaalenii PYR-1
ZP_01208620.1, EAS21834.1
78% to 130A1
MTAVLSHGSPVHFALADASTWADPWPMYRALRDHDPVHHVVPEDRPNHDYYVLSRHADIWAAARDHQTFS SALGLTVNYGELDLIGLADNPPMVMQDPPVHTEFRKLVARGFTPRQVEAVEPKVHDFVVDRIEHLRANGG GDIVAELFKPLPSMVVAHYLGVPDEDRGKFDGWTDAIVAANTSAGGLGGALDTLGDALGEMMSYFTALIE RRRTEPEDDTISHLVAAGVGADGDISGVLSILAFTFTMVTGGNDTTTGMLGGSVQLLHRRPDQRTMLAEN PDLIPDAVDEFLRLTSPVQMLGRTVTHDVTIGDVTIPEGRRVMFLYGSGNRDERQYGDDAGELDVTRKPR NILTFSHGAHHCLGAAAARMQSRVALTELLTRIPDFEVDESGIAWAGGSYVRRPVSVPFTVTH
CYP130A6P Mycobacterium leprae strain TN
GenPept AL583920.1
59% to CYP130A1
VMSHRFRFTTADIWPNPWSMYRTLRDHEAVHHVVPANQPEDDYYVLPRHADVWSMAMRS
HAKLSSAQRLTVNYSDMELIGLQDNPPMVMQDQPV*TKCRKLVSRRFTPRQTNVVEPKVR
HFVVEHIEQLRAKGSVDIVTELFKPLPPMVVAHYFGFPEKVRSQFDGW
TTAADGGGALFRFPRKSPITIRRLAPAIVAANTADAGGITNELDVAGYAVESMLAYFTR
IATGGNNTVTGMLGG*MPL
SHRRKQHRHWHARRLDAVKDTAEAD
LLRLTSSVRGLMRTTTRDVAIGHTTVSPGRRVLMRYGQAKRDER*YSAAAS*LDVTW*
PPNILIFSHGAH
YLGAKVTRMQRR
VRLTELLARYPDFEVDESSIAWAGGKLHTTP
131 Family
CYP131A1 Streptomyces peucetius
GenEMBL L47164(3444bp)
coding region 32-1348
gene dnrQ duanosamine biosynthesis
possible sequence errors at C-terminal (no recognizable signature sequence
in the last 68 amino acids)
CYP131A2 Streptomyces sp.
GenEMBL L35154 (4134bp)
3838-4134 N-terminal fragment 94% identical to L47164
gene dauQ daunomycin biosynthesis
132 Family
CYP132A1 Mycobacterium tuberculosis
GenEMBL Z80108 (40778bp) gi 1542902 Rv1394c
complement (9842-11227)
most often matches CYP4 family in blast search
CYP132A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(1566263..1567648)
Gene = cyp132 1 aa diff
locus_tag = Mb1429c
133 Family
CYP133A1 Erwinia herbicola
Randy S. Fischer, Roy A. Jensen
First P450 from an enteric bacteria (similar to E. coli)
submitted to nomenclature committee
CYP133B1v1 Xylella fastidiosa, section 35 of 22.
AE003889 CDS complement(3751..4959)
82% to AE003887 48% to CYP133A1
CYP133B1v1 Xylella fastidiosa 9a5c
GenPept AAF83187
100% match
1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYMES
61 MRVRYGDSAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG IAVSKIAKVF DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN
CYP133B1v2 Xylella fastidiosa Temecula1
GenPept AAO29526
6 diffs to CYP133B1v1
1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYIES
61 IRLRYGDTAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG MAVSKIAKVL DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN
CYP133B1v3 Xylella fastidiosa Dixon
NZ_AAAL01000071 complement(6849..8057)
98% to 133B1v1 7 diffs 97% TO 133B1v2 11 diffs
gene = XfasA0474
MKLTDLSNPAILENPYPLYETLRAQAPFVSIGPNALMTGRYSLV
DSLLHNRNMGKNYMESMRVRYGDSAADMPLFQAFNRMFITINPPAHTHLRGLVMQAFT
GRESESMRPLVIDTAHQLIDNFEQKPSVDLVAEFAFPFPMQIICKMMDVDIGDAVTLG
MAVSKIAKVFDPSPMSADELVHASTAYEELAQYFTKLIELRRTHPGTDLISMFLRAEE
DGEKLTHDEIVSNVIMLLIAGYETTSNMIGNALIALHRHPEQLTLLKSDLSLMPQAVS
ECLRYDGSVQFTMRAAMDDIEVEGELVPRGTVVFLMLGAANRDPAQFTHPDQLDITRK
QGRLQSFGAGIHHCLGYRLALIELECALTALFERLPHLRLAHLDALNWNQRSNLRGVN
TLIVDLHAKN
CYP133B2v1 Xylella fastidiosa, section 33 of 22
AE003887 CDS 6723..7925
82% to AE003889 48% to CYP133A1
CYP133B2v2 Xylella fastidiosa Ann-1
NZ_AAAM01000051 complement(2764..3966)
97% TO 133B2v1 8 diffs
gene = XfasO1476
MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLATDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLS
VAVSNIAKVFDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLSGYETASNMIGNALIALHRHPKQLARLKSDLSLMPQTVL
ECLRYDGSVQFTVRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP
CYP133B2v3 Xylella fastidiosa Dixon
NZ_AAAL01000066 complement(2275..3477)
97% TO 133B2v1 9 diffs 10 diffs to CYP133B2v2
gene = XfasA0420
MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLAIDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMHVDISDAISLS
VAVSNLAKVLDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAVL
ECLRYDGSVQFTIRAAIDDVSIEGDVVPRGTIVFLMLGAANRDPVQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP
CYP133B3 Xanthomonas axonopodis pv. citri str. 306
GenPept AAM38014
56% to 133B2
1 MLLSDLATPQ FRHDPYPTYA RLREEGPLVQ VADGRLMSGR YAVVDRLLSD RRVGRDYLQS
61 VRLRYGEAAV HLPLFQGMSR MFLLLNPPLH TQLRGLMTQA FGARQMESMR EVASDIAAGL
121 IDAFQANGHC DLLTEFAFPL PIAIICRMLD IAAADVTALS HATSALAKVF DPMMTAEELQ
181 ATSVAYDQLA TYFHGVIAQR RSAGGDDLIA RFIQAEDNGR RLSEEEIVSN VILLFFAGHE
241 TTSNMICNAL VALHRHPQQL RLLQETPGLL PNAVLECMRY DSSVQMATRT ALQDFEIEGV
301 AVPRGTMLYL MLGAANHDTL QFTDPQVLDI RRQQGRALSL GGGIHHCLGN RLALIEVEAA
361 LACLLARLPA LRLEQLDTLS WNDRANLRGV DALLASW
CYP133B4 Xanthomonas campestris pv. Campestris str. ATCC 33913
GenPept AAM42318
BioI biotin synthesis
52% to 133B2 65% to 133B3
1 MQLSDFATPA FRQDPYPMYA RLRAAGPLVQ ISDNGWVSGH YTVVDALLSD RRVGRNYLDS
61 IRVRYGANAA EMPLFQGMSR MFLLLNPPVH TQQRALMTKA FGARQLEALR EVAVDTADAL
121 LDQHEDRRSC DLLNDFAMPM TISLICRMLG LAVTDVAALG QASSALAKVF DPLMRPEDMA
181 QATAAYTTLE QYFRAIVLQR RDTQEDDLIA RLIAAEDHGQ RMPVDDIVSN VIMLFTAGHE
241 TTANMICNAL IALHRHPEQL QLLRDTPTLM PNAVLECMRY DSSVQVAMRS VLQPLQVEGT
301 TLPVGAILYL MLGSANHDAE QFTAPQQLDL RRQQGRALSF GGGVHHCLGN RLALIELETA
361 LERLLQRAPA LRLPELDNLS WNERANLRGI QALHATW
CYP133B5 Ralstonia solanacearum GMI1000 megaplasmid
GenEMBL AL646080 77388..78584
gene = RSp0709
77% to CYP133B2v2
MKLADLSTPSFLENPYPLYETLRSQGPFVRIGPNALMTGHYSIV
DALLHNRQMGKSYMESIRLRYGDEGPNMPLFQGFSRMFLMLNPPMHTRLRGLMMQVFN
ARQIESMREVATATAHQLIDDFEQKPSADLVAEFAFPLPVRIICQMMDLDIDDAMALG
VGVSKLAKVFDPAPMSADALVETSAAYEELAQYFTKVIEARRAQPGTDLISMLMRAEE
NGETLTHDEIVSNVILLFIAGHETTSNMIGNALIALHRNPQQLDLLKREPSRMPNAVL
ECLRYDGSVQVTIRAALEDVEVEGEVLPRGTTVFLMLGAANRDPAQFTDPDQLDIGRQ
QGRLQTFGAGIHHCLGYRLALIELESALGALFERLPNLRLTNLDQLSWNQRGNLRGVN
ALMAAW
CYP134A1 Bacillus subtilis
GenEMBL AF017113, Z99121, Z99122
cypB also called cypX
CYP134A2P Bacillus cereus ATCC 14579
GenPept AAP10061
57% to CYP134A1 cypX Z99122 Bacillus subtilis C-term
1 MIGATNCDSN VFERPDKFNV YRPDIDIKKA FSGTARHLAF GLSIYNCVGV AFAKLKIEID
61 STIKDNISRK KLRDIKDFVK KTSKMN
CYP134B1 Photorhabdus luminescens subsp. laumondii TTO1
GenEMBL NC_005126 complete genome complement(313663..314886)
locus_tag = plu0296
46% to CYP134A1
MAKLSSFNIHDPKFIKNPYDFYDILHKQDLVYFEQSQNSYFIGK
YEDVDAILKSSIFNTKPLTALAEPVMGDRVLAQMEGEEHACKRKFIMQGLSRDYFNRY
YEPMIRKITEDLLQPYMEKGNIDIVNDFGRDYAVLVTLSILGLPSDNYRDIAEWHKGI
ASFITQFDQTELEKMHSLECSQKLIRLLKPIIDQRRRNPSKDIISIFCQDTAMSMSEI
TALCLNILLAATEPADKILAMMLNHLISNPSMLDVVLKDRSLVRDAFEETLRLTSPVQ
LIPREASEDVTISGIDIPKGAVVFCMIGAANRDPSVFHKPNEFDLYRRKNTTSPQKAN
RKRHLAFGAGTHACAAAAFSLSQLEVSSNIILDLLHNLRFADHYHYQETGVYTRGPSK
LLLSFDPIASSAIKE
CYP135A1 Mycobacterium tuberculosis
GenEMBL Z96800
Rv0327c
CYP135A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(393726..395075)
Gene = cyp135A1 1 aa diff
locus_tag = Mb0334c
CYP135B1 Mycobacterium tuberculosis
GenEMBL AL021942
Rv0568
CYP135B1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 660693..662111
Gene = cyp135B1 100% match
locus_tag = Mb0583
CYP135B2 Mycobacterium smegmatis
68% to 135B1
MSTPGTLPPGPPLPAFVQTAMMLRHWSRFVSACRRRYGDVFTLRIASMGT
WVYLADPADIKTVFAGDPTVFHAGEANSMLSGLLGETSVLVIDEDVHRDR
RRLMLAPFARDAVARQTGVMAEVAATNIASWPVGTPFPVAPKMAEIALEV
ILRTVIGATEPARLAALRHVMPQLLGIGPWQSLAIASPGLQRRRPWRTLQ
RNLAEADRLLYAEIAACRAGPDLASRPDALAMLVRAANDEGRTMTDRELR
DQLMTLLVAGHETTATGLSWTLERLIRHPAVLDKAVAAARTTDGSGEAYL
DAVVRESLRIRPVVFEAGRVLTEPVELGGYLLPAGTLVAPSIGLVHASAD
VYPDPDRFEPDRMLASTQAPSTWLPFGGGNRRCLGATFALVEMRVVLREI
LHRVDLFATTARGEKQRLKHVTMIPHRGGRICVRALRDVAPAPMTCPAEA
RRA
CYP135B3 Mycobacterium marinum
No accession number
Tim Stinear
MM4483
71% to 135B1
CYP135B4 Mycobacterium marinum
No accession number
Tim Stinear
MM0938
75% to 135B1
CYP135B5 Mycobacterium vanbaalenii PYR-1
ZP_01204401.1, EAS25393.1
73% to 135B1
MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLRCGPRFVAACRRRYGSAFTLRVASMGTLVYLT DPADIKTVFAGDPDIYHAGEANSMLKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAA DNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGPWETLAIANQDLLRRRP WRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVRAGDMSDKELRDQLITLLVAGHDTTATALSW ALERLTRHPAVLAKAVRAARDGDDDYLDAVAKETLRDRPVVFDVGRVLKAPVELAGYRLPAGVMVIPGLV AVHADSQIYPHADRFDPDRMLGATLSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARG
EHRRLKHVIFVPHRGARIRVRAKRVVAAEAPKCPMSGPA
CYP135B6 Mycobacterium marinum
No accession number
Tim Stinear
MM2978
64% to 135B1
formerly CYP135B2 but that name was already assigned
to a Mycobacterium smegmatis sequence (my error).
CYP136A1 Mycobacterium tuberculosis
GenEMBL Z83866
coding region 23158-24636
Rv3059
CYP136A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 3376038..3377516
Gene = cyp136 1 aa diff
locus_tag = Mb3085
CYP136A1 Mycobacterium marinum
No accession number
Tim Stinear
MM1634
86% to 136A1
note name change from 136A2 since all
CYP136As seem to be orthologs
CYP136A1 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 136A2 M. marinum = ortholog
note name change from 136A2 since all
CYP136As seem to be orthologs
CYP136A1 Mycobacterium smegmatis
MSMEG0997 TIGR
MSMEG2291 TIGR
65% to CYP136A1 M. tub.
88% to ZP_01203885.1 Mycobacterium vanbaalenii
note name change from 136A2 since all
CYP136As seem to be orthologs
MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP
AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS
SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR
RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD
IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ
ARKTLEDYFLSRIDEKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMIF
LMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEKL
ETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINHR
LPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLEI
KTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR
CYP136A1 Mycobacterium vanbaalenii PYR-1
ZP_01203885.1, EAS24877.1
65% to 136A1 M. tub
MPSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPPAGSDLKPILGDAGLPIIGHMI EIFRGGPDFILEIYRKHGPVYFAESPALSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLL DFDEHMFHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLDIASEVFMGVPA GTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIKARKTLEDYFSSRIGEKRRSESTDMFSVLCHS ADEDGQSFTDDQIVSHMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEKLE TYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINHRLPELWTDPEKFDPERFAEPRS EHKKHRYAFAPFGGGAHKCIGMVFGQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLR PLH
CYP136B1 Mycobacterium smegmatis
MSMEG1160 TIGR
43% to 136A1, 42% to 136D1
MTIPAAEAAADAKVRLQTAVAGITARYPSREHALAAPPPGSGLKPV
MGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVGFRVALLMGPE
ALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRDHRRIMQQAF
TRSALNGYLDLMRPGIDRTVRSWPAAQRFPFYTSVKHLLLDQAAEVFIGA
ELGPEADQLSRDFHDTVCGGQAVIRADVPGGVWSRGLRARRRLERYFAGQ
LPARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNHMIFLLMAAHDTSAIA
ISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDLDSAYPLLDAAFKESL
RMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGVYASMRLADWWPEPDEF
DPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQFANMNVKAIMLHLLRHF
RWHVPAGYQPRMTWGTGPTPADGLPITLERLSA
CYP136B2 Mycobacterium flavescens PYR-GCK
ZP_01192884.1, EAS10792.1
78% to MSMEG1160 CYP136B1
MSALPQSLPG LPAASAKLRF QSAAASVTSR YPSRVRPLSR PPAGSGLKPV LGNYGFPVLG
HHLSTFVEPL EFARERYERF GPVSWAGGIG FRVVQLMGPE ALETAWINRD KAFSSTRGWA
PVIGPFFHRG IMLLDFEEHR DHRRIMQQAF TRSALDGYLT LMRPGISRTV TSWPTAAGFP
FYTAIKKLLL DQAAEVFVGA VLGAEADRLS SDFHDTVCGG QAMIRADVPG GTWARGLRAR
ERLERYFAAQ IPDRRAGTGA DLFSMMCRSR SEDGDSFSDA DIVNHMIFLL MAAHDTSAIA
ISMLVYELGR NLRWQDALRD EADAGDGLGL ADLDGAYPLL DAAFKEILRM YAPAGTLFRQ
TVTDTEVCGH YIPRRTQVAI NVYASLRLAD WWPDPDRFDP GRFLGGGDAA AVHRYAFAPF
GGGVHKCIGQ QFADMNVKLV MHQLLRQFRW RVAPGYRPLM TWGTGPTPAD GLPISLQRLSGG
CYP136B3 Mycobacterium sp. KMS
ZP_01282080.1
72% to MSMEG1160 CYP136B1
MTALTAQLTS PANTHRLQVA GAALTSRFPS REEPLATPPP GSNLKPVMGN YGFPFLGHTL
SALAEPLDFA RRRYDMYGPV SWAGGVGFRV VALMGPDALE TAWINRDKVF SSTRGWAPVI
GPFFHRGIML LDFEEHRDHR RIMQQAFART ALDGYLELMR PGIDRTLGGW PASDAFPFYP
SIKHLLLEQA AEVFVGTHLG PESDQLSADF HDTVRGGQAL LRADVPGGVW ARGLRARKRL
ERYFGDQIAD RQRGDGADLF SMLCRSEDDD GARFTPADIV NHMIFLLMAA HDTTAIALSM
LVYELGRNQK WQKTLRDEAV GRPNDAPAVG DLDAYPLLDA AFKEILRMYA PAGTLFRQTT
RDTDILGHFV PAKTQVAINV HASMRLADWW PDPDTFDPAR FIDQPGARAA VSRYAFAPFG
GGAHKCIGQQ FADMTVKTTM HQMLRRFEWS VADGYRIPLT WGTGPTPADD LPITLRTLTT
CYP136B4 Nocardia farcinica IFM 10152
YP_117347.1, BAD55983.1
54% to MSMEG1160 CYP136B1
MVEITRSVAK GFGMSLQLPT TVSAVSDNAR HLRTRLSWQA QRAGLQVVKR YPTRIRPLAE
PPPGSGLKPV LGDFGPPGIG YTLHTLADPM GFSRERFERL GPVSWLGVLG RPVVSVAGPE
AFEEVLLDRD KVYSAQRGWE WLIGPFFHGG VMLRDFDDHM FHRRILQQAF TRPRLHGYQD
LTSPLLRRGI ESWRPAAEFH IHTAIKQLLL QQATEVFAGA ELGRESVALA HAFEDAVHGG
TAMVRANVPG GVWARGLRGR RRLEDYFRRE LPAKRAGEGN DLFSVLSRAT TEEGHTFTDE
EVVQHMIFVM LAAHDTSTIA SSMLVYELGR HPEWQDKLRA EAIGLGKESV GYDDLDELPL
LDMAFKEALR MYAPVAQQAR ETIADTALCG HYLPRGTLVM CGPYMMMRTA RYWRDPDEFD
PERFAPERRE DKSHRFAWAP FGGGAHKCIG LYFGGMTVKA VLYQMLTRFR WSVRPGYEPL
LVAGTGPTPA DGLPIRLERL AR
CYP136C1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha02367
Submitted to nomenclature committee 12/13/04
48% to 136D1, 74% to 136C2
CYP136C2 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha06567
Submitted to nomenclature committee 12/13/04
49% to 136D1
CYP136C3 Frankia sp. CcI3
YP_481755.1
ABD12026.1
not like Frankia alni P450s
53% to CYP136C1 Rhodococcus sp. RHA1
MAVRGSRGPVPGDGGPPLVGYTLRYLHDPAQHWRQRYDRYGPVSWERTFGLRVVSLLGPDATGLALRNHE
QAFANGPGQQRIAGPFFRRGLSMLDFDEHRHHRRILAGAFAPDRLRGYLAGMNPSIERGVAGWRPGARFQ
VYPAVKQLTLELATRIFMGERLGPEADRFNAALFACIRAPGAVVRVPAPGLRWSRGLAGRRYLEEFLRLR
VPAKRAGSGTDMFSRLCHAEAEDGSRLSDDDVVNHMILMMVAAHDTSTITMTSMSYYLARHPEWQQRCRE
ESLALGTPAVDHADLDRLPSLALVMKEALRLVTPVPILLRATVKDIDVLGVTVPAGTVAALALAFTHQMP
EYWPSPERFDPERFADHRREDKVHPYAWQPFGGGPHTCIGLHFAGQQVKAILHQMLLRYRWSLAPGYRIS
LDRFPLPVPRDGLPVQLEKIT
CYP136C4 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
84% to CYP136C2 Rhodococcus sp. RHA1
CYP136C5P Rhodococcus sp. R04
AFAQ01002075.1 47570-47776 (-) strand
Riu Xue
Submitted to nomenclature committee Feb. 28, 2012
73% to CYP136C2 Rhodococcus sp. RHA1
CYP136C5P Rhodococcus pyridinivorans AK37
AHBW01000043.1 60959-61165 (+)
2 aa diffs to CYP136C5P Rhodococcus sp. R04
CYP136D1 Mycobacterium abscessus
GenPept AAN38721
46% to CYP136A1
name change from 136B1
1 MDAVEAAQRP GGTMTNHLLA PAHHVKERLS SVIMVPAPHA VDDRWRRWSR DWPVRELAPA
61 PAGSGLKAVR GDAGLPFVGH TLDYIRFGSD FSRERYDRLG SVSWMGAFGT KMVVIAGPDA
121 TREAFTSEAK AFSQDGWSFL IDAFFHRGLM LMSFDEHLMH RRIMQEAFTR PRLTGYVEQV
181 TPCVRSAVPA WPVGPSVRIY PLLKELTLDI ATDVFMGGRG KDESDAVNKA FVATVRAASS
241 LVRAPLPGTR FRAGVQGRRV LEDYFFRHLP AARAGETEDL FAALCQATTE DGERFSDEDV
301 VNHMIFLMMA AHDTSTITTT AVTYFLAKYP QWQEAAAAEA AAIGDGLPDI EALEKMTVID
361 RVIKEALRLL APVPLVMRKT VRDVAIDGYH IPSNTLCAIT PAVNHFDRTI WNDPERFDPS
421 RFDEPRREDQ HHRFAWVPFG GGAHKCIGMQ FGTLEVKAIL HRMLRSFTWK VPENYHVRWD
481 NTSLPIPVDG LPLEMKRR
CYP136D2 Mycobacterium marinum
No accession number
Tim Stinear
MM3315
85% to 136D1
name change from 136B2
CYP137A1 Mycobacterium tuberculosis
GenEMBL AL022121
Rv3685c
CYP137A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(4064642..4066072)
Gene = cyp137 1 aa diff
locus_tag = Mb3710c
CYP137A2 Mycobacterium marinum
No accession number
Tim Stinear
MM5175
83% to 137A1
CYP137A2P Mycobacterium ulcerans
No accession number
Tim Stinear
100% to 137A2 M. marinum = ortholog except for insertion
and one stop codon
CYP137A3 Mycobacterium vanbaalenii PYR-1
ZP_01208503.1, EAS22069.1
61% TO CYP137 Rv3685c AL022121 Mycobacterium tuberculosis
MAEHSPHESYRCEMVHIVRPPSLPAPPPLAPVFGGLYAAAFGMGGQAIVAQMVRRYGPVVALPVLGFGKV VAVADAALAKQVFTENPDVLLGGEGVGPAAAIYGPRSMFVLEEPGHLRRRRLLTPPLHGELLGSYVPIIE SSTRSAMATWPVGRPMRMLDAARELTLDVIVQVVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRR FGALRRWGRLSDANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRDDLITLVLA GHETTATTLSWLIDLLLHHPRALARVRAEAVSGDTGYTEAVIAETLRLRPAAPITGRMTTGPYRLGDYTL EPDTRIVLLLDVINRNPDTYPQPDEFRPERFLGSRPHPYAWIPFGGGVKRCIGAAFAMRELTTTLHTVLR EGELEPVSARPETPPLRAAPVLVPRDGTRVRFTPARPAASPRCADRTSTV
CYP138A1 Mycobacterium tuberculosis
GenEMBL Z92770
Rv0136
CYP138A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 163556..164881
Gene = cyp138 100% match
locus_tag = Mb0141
CYP138A2 Mycobacterium smegmatis
66% to CYP138A1
MTATVERPESAIRAAQLPPVLPLPKTVQGLAFSVARRWVVKQAARRYGDV
VTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPNLSRMLGPGSVFAL
DGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAASWPDGQEFRTLEP
MMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRNYGR
LTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGS
SMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAATD
DNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAH
IQEREEEFSDPHRFDPQRFVGNRPGLGWLPYGGGTRRCVGAVFANIEMDV
VLRTILRHFVIETTTAPDEKVHPRGVAYTPASGGRVVMRRRREPLGA
CYP138A3 Mycobacterium marinum
No accession number
Tim Stinear
MM0346
75% to 138A1
CYP138A3P Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 138A3 M. marinum = ortholog except for insertion
CYP138A4 Mycobacterium marinum
No accession number
Tim Stinear
MM3976
55% to 138A1
CYP138A4P Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 138A4 M. marinum = ortholog in the conserved region
CYP138A5 Mycobacterium vanbaalenii PYR-1
ZP_01206398.1, EAS24160.1
70% to 138A1
MSEATIAAHRSTADAESAPPRPVRLPPTPRIPKLLQGLGFSFSRQWTVAQIVRRYGDVFSMTLPVFGPTV MVADPALAKQLFMANTDDVGNIQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEET LREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTPHRTYGRFS PWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRSTYEDGSTMSRQDIGDELLTLLAAGHETT AATLGWAFERISRHPEVLAKLVAEAETDGNEYRQATILEIQRSRTVIDFAGRHVYAPTFELGEWVIPQGY SIVVAIGQVHKRAQDFDDPDRFDPQRYIGQRPPTFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVI
ETTAAPGEKMHSRGVAYTPKDGGRVVMRRR
CYP138A6P Mycobacterium leprae
GenPept CAC32181 GenEMBL AL583926
NC_002677 complement(3167438..3168451)
locus_tag = ML2648
Sequence below is from TIGR primary nucleotide sequence for ML2648
40% to CYP138
1 NRVAREIVVEVIYGALFGAFEALSGLVPQDTVLGPMGRYSMAPSLIR
439 ITINVIMRAGFGSELDELRRLHPTAATL 522
RWTVERQARCNHDIFMLDSRSTAERLRRRLHGTCMKNH 351
352 VRIFEAEPLWGLRTGLKASLLPHCRLINRITINVIMRAGFGSELDELRRLHPTAA 516
517 TLVGLF*LLSQHLGVLADPSSMGATMPGDDPAPALRQATIPG
638 LGVQWTRTVIDFAARRVYSSVYHLSEWAIPREDSILISIAQIYXXXXXXXXXXXX 766
795 DPRRYVEHKPSSFAWI 842
PFSGGT 861
862 SRCVSICQDGDGMNVVLKMVLRYWIIDTTTAPGER*HLRGVVYTPRNGGR 1011
CYP138B1 Mycobacterium marinum
No accession number
Tim Stinear
MM4430
65% to 138A1
CYP138C1 Mycobacterium vanbaalenii PYR-1
ZP_01207105.1, EAS23276.1
49% to 138A1, 48% to 138B1
MATATTDPVRLPPGPRIPKLIQGAAVLTQRYGAIAALGRRYGPTFTLNIPVFGETVVISDPVLVKDLFST HRDLVGRPQNNLGGDVLGPGSIFNLEGDALQARRKLLLPPFNGKSMRGYASITEEEAIREIRTWPEGVEF ETLEPMMRITLNTILRAVFGAEGEQLDELRELMPKAVEFGSKIALMPSIVRKDFGPWSPGGKFARYRKRM DELLNGLLNDARSDPNFTERNDVLSLLLQARYDDGSPMPDSFILDELLTMLVAGHETTSTQLAWTIERIR RHPQLLVRLTEEVDAGGNELLLATIAESQRTRPVLTAALRRARTRIRLGEWVIPEGDTILASTQLAMAAE SSFPDADKFNPDRFVGNPPNPFAWIPFGGGMMRCIGASFATMEMEVTLRALLREFTIEPTTEPDEKPHSR
GVTVTPGRNGRLVVHRREHKAARATDSVSVAESS
CYP138C2 Mycobacterium flavescens PYR-GCK
ZP_01193212.1, EAS10582.1
83% to 138C1
MATATTDPVR LPPGPRFPKL IQGGAVLAFR YGSVAALGRR YGSTFTLQLP VFGETVVISD
PVLVKDLFST SRELVGRPQN NLGGDVLGPG SIFNLEGDEL LARRKLLLPP FNGKNMRAYE
DITEQEVIRE MQSWPEGVEF ETLEPMMRIT LNTILRAVFG AKGDELDELR VVIPAAVEFG
SKIALLPSVV RKDLGAWSPG GKFARYRRRM DEICTQLIAD ARSDPDFTDR GDVLSLLLQA
RYDNGDPIPD AFVVDELLTM LVAGHETTST QLAWTIERIR RHPDLLARLS DEVDAGGNEL
MAATIAESQR TRPVLTAALR RARTRIRLGE WVIPEGDTIM ASTQLAMAAE QSFPDAEKFN
PDRFVGNPPN PFAWIPFGGG MMRCIGASFA TMEMDVTLRT MLREFRLEPT DEPDEKPHSR
GVTVTPGRGG RAVVRRRRTP ASGDANSVSV AETSR
CYP139A1 Mycobacterium tuberculosis
GenEMBL Z95617 GenPept AAK45973 (with 7 more aa at N-term)
Rv1666c
CYP139A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(1877656..1878948)
Gene = cyp139 start codon differs by 6 aa
locus_tag = Mb1694c
CYP139A2P Mycobacterium leprae
GenPept CAC31622 GenEMBL AL583921.1
NC_002677 complement(1474970..1475188) and
complement(1474991..1475161)
locus_tags = ML1237 ML1238
61% to CYP139A1
GAAVATTSMTVILARLASRTRLHLLAHYTHRVRARNFAALIP*LSLTVEVINSMPTQ
CYP139A3 Mycobacterium marinum
No accession number
Tim Stinear
MM2475
79% to 139A1
CYP139A3P Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 139A3 M. marinum = ortholog in the conserved region
CYP140A1 Mycobacterium tuberculosis
GenEMBL Z97193
Rv1880c
CYP140A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(2120751..2122067)
Gene = cyp140A1 100% match
locus_tag = Mb1912c
CYP140A2 Mycobacterium smegmatis
MSMEG0673 TIGR
65% to CYP140A1
76% to 140A6 Mycobacterium vanbaalenii
64% to 140A1
MRERLRWMALHGFVRSMATLGLRRGDPQARLIADPVVRADPTTFADQMRKQGPVIRG
RVVLLTFDHAVAFDLLRSDDFQVSQLGANLPKPLRWIADKTNPGLLHPIE
PPSLLSIEPPDHTRMRKLVSSVFTTRAVATLRERVEQTAHELLDGLEAES
GVVDIVERYCAQLPVAVIGDILGVPEPDRPNILRYGELGAPSLDIGLSWS
QYQQVNEGIIGFETWLNRHLRTLRRDPGDDLLSQIITASESGATGEPLTD
RELKALAGLVLAAGFETTVNLLGNGIRMLLDHREHLETLAARPDVWPNAV
EEILRLDSPVQMTARAAVRDVDVAGTAVGRGELVVLHIAGANRDPKVFDD
PHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRAFFDRFPDARL
AGDPVRRDTRVLRGWSTLPIALGKARAAVGS
CYP140A3P Mycobacterium leprae TN
GenEMBL L01095.1
48% to 140A1
VRQRLHWFAQYGFIRGIAATHH
RRSDPLARLDIALAIKANPVP
YCHKPRPRRPLVQSRISYLTANRAITHELLQSEDFHVFWLNVTLPAPSHWL
RRRTGYRTSSQYNL
LHPLLAIQ*AYHIHYRKTVSPLFAPKAVATLRDRIEQTTLALLDQLAHQHDVVDVVNRY
CSQLPVAVISDILGYP
VPDRDRSHILKFGELVAPSLDVELT*Q*YQQA*REVAGFNFWL
LKHLPQLQRTPGDNLVRHLSH*EDNKPTEISLSKSKLQAISG
GLVLATGGETTVNLLGRGI
LLLDTPEHMVMLQACPEPGHKRG*EILRLDSPIQMAARVARKDVDLAGSTIKRSQVVVLY
FGRSQPGPVRLCRSR*VQHRTPQCGKESRIFR*QEFCLENALTRAYNAVGLRAFFDHLP*
TRAAGTRSRLDTRVLRGWSTLPIALGPTRSMVS
CYP140A4 Mycobacterium avium subsp. paratuberculosis
GenEMBL AJ250018 complement(2795..>3145)
59% to 140A1 runs off end
GAAARQSRPVGPRRSRRSCDRQPGPDDRAHAPPATSTSAPAMVG
LVPRRARNRDPKVFSDPTTFDVTRPNAREHLAFASGIHACLGAALARIEGATCARSFE
NFPDRSSRARNGGR
CYP140A5 Mycobacterium marinum
No accession number
Tim Stinear
MM2768
80% to 140A1, 62% to CYP140A7
CYP140A5 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 140A5 M. marinum = ortholog
CYP140A6 Mycobacterium vanbaalenii PYR-1
ZP_01208430.1, EAS21996.1
66% to 140A1
MAADLQQRIRWLALHGVIRGLSKVAVRRGQDPQARLIADPAVRADPAAFADELRGRGPVIRCRAVLMTVD HQVVNEILRSDDFRVSSLGAGLPKPLQWINRKTHPGLLHPIEPPSLLSIEPPDHTRCRKLVSSVFTTRAV AALRERVQQTANDLLDDLERESGVVDIVERYCSQLPVAVISDILGVPERDRRHILHFGELGAPSLDIGLS WRQYTQVHEGLVGFNEWLGGHMDELRRNPGDDLMSQLIQASQAADEGSRLTDRELQATAGLVLAAGFETT VNLLGNGIRMLLETPGHLETLAARPELWPNAVEEILRLDSPVQMSARFARRDVTVGGTEIKRGELVILHL AGANRDPEVFTDPHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRTFFERYPDARLAGQGSRRD TRVLRGWSTLPITLGTARAALGS
CYP140A7 Mycobacterium ulcerans
No accession number
Pam Small
Submitted to nomenclature committee 10/17/2003
62% to CYP140A1
formerly 140A2 but that name was already assigned
to a M. smegmatis seq. (my error)
CYP140B1 Mycobacterium vanbaalenii PYR-1
ZP_01206566.1, EAS24328.1
43% to 140A1, 47% to 140A6
MGQHAGRQAGPGGAGRPVGRSGARRSGGGQPWAARAAGRRRAQVGAGAGPGSGRAAHGRHLRRPSPRQPD RRMRSRPAVWLRWATVHGVPRAFLTVRARRGEPLARLILGRGDRLALIEEIRAAGPLMRTPVVWATADYD VCRTVLRDNDFGVADPSETGLPDALLGLIRRVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFTPRSIA ALDTRIGELTAELLDDLGRRREVDLIADYAAQLPAAVISRMLGVPDEDRARILGWGETGAALLDIGIGWR PFRAAIDGLVDVDTHLGAHFRRLHQNGADGTPFSSLALDGSLSGRELISNAALLVGAGVETTVNLIGNGI AALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTARTAHRDTEIAGVGIRKGAVIVMLLGGANRDPK VFDRPQTFDITRANARDHLAFASGIHVCLGAALARIEGATALRELFTRYPDLHLTAPAEPRDLVTLHGYR HLPVRLGRAATATRRAS
CYP140C1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE1265 48% to CYP140A6
CYP140C2P Frankia sp. EAN1pec
YP_001510627.1
ABW15721.1
51% to CYP140A5 Mycobacterium marinum
formerly CYP140C1P
MSVRPAVSARPALSVRPAMSVRESLRDNALGMVLDMSALPAPLRLMARLSPDPAVNGPLDPPSLLAIDPP
DHTRLRRLVSKVFTPRAVDGLRGEVERAADALLDAMADEGTVDLVGRCASRLPVTVIATILGVPAAMHAQ
FLAWGTAAAATLDFGLPYGAFRRVERAQQAINTWLRGHFEGLRRDPGEDILSQLVRLVDDGDRLTETELI
ATAQLLLAAGFETTVNLLGNGAALLMEHPDQLEYLRSGPDRW
CYP141A1 Mycobacterium tuberculosis
GenEMBL Z95150
Rv3121
cosmid cY164 from Sanger Centre
coding region 29289-30488
CYP141A1P Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 3441289-3441483
aa 337-400 (first part of gene is in a deletion)
IAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT*
CYP142A1 Mycobacterium tuberculosis
GenEMBL
Rv3518c
CYP142A1aP Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(3898119..3898736)
gene = CYP142A1a aa 1-197 100%
locus_tag = Mb3548c
In Mycobacterium bovis, a frameshift due to a single base
deletion (c-*) splits cyp142 into 2 parts (pseudogene)
CYP142A1bP Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(3897541..3898122)
gene = CYP142A1b aa 207-end 100%
locus_tag = Mb3547c
In Mycobacterium bovis, a frameshift due to a single base
deletion (c-*) splits cyp142 into 2 parts (pseudogene)
CYP142A2 Mycobacterium smegmatis
MSMEG5877 TIGR
86% to CYP142A4 Mycobacterium vanbaalenii
78% to CYP142A1
MTQMLTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQ
AVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRK
RVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPT
ERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEP
TDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLL
RHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRA
GEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLAR
LELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA
CYP142A3 Mycobacterium marinum
No accession number
Tim Stinear
MM5003
92% to 142A1
CYP142A3 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 142A3 M. marinum = ortholog
CYP142A4 Mycobacterium vanbaalenii PYR-1
ZP_01207590.1, EAS23149.1
78% to 142A1
MTSTLPALDVDLADGNFYADGRAAREAYKWMRANQPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIR PDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDKVPSIENLCDTLIDAVCERGECDFVRDIAAPLPMA VIGDMLGVLPDERDMLLKWSDDLVCGLSSTVDEQTIQKLMDTFAAYTAFTTEVIADRRANPRDDLFSVLV NAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHQDQWRQAVADPELLPGAIEEMLRWTSP VKNMCRTLTADTEFHGTSLKAGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA RLELRLMLTKILQRLPDLRLADESMLPLRPANFVSGLESMPVVFTPTAPVGA
CYP142A5 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05910
Submitted to nomenclature committee 12/13/04
64% to 142A1
formerly 142A2 but that name was already assigned
to a M. smegmatis seq. (my error)
CYP142B1 Mycobacterium vanbaalenii PYR-1
ZP_01204842.1, EAS25834.1
44% to 124A1, 43% to 268A1, 45% to 142A5
MTTAVPTHRDIDLSDRNFWARPHEERDAAFAVLRRENPVPWSRPADSDLLPPEQNLKGFWSLTKHEDIRY ASRHPEIFSSAEGITVEDFPVEIRMMSQSFIAMDAPRHTQLRGITLDAFKPRNMLRLQDWIQGHARDLIS EISHLGEGDFVDLVSVKLPGRIFGSFFGLPPGELHEKTINAAQRTLGWTDPEVRGDLTAVELFVGAVMDL HETVTTLLPERRANPGDDLLSWMVQAEFDGEKMTDDELKAFFTLLAVAANDTTRHASAHAILAFSQFPDQ RDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQDVTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKF DIARNPNPHIAFGGGGPHFCLGAALARTMLRSLLTEVYTRIPDISAPEPRYQVANFINGINSLPATWTPERR
CYP142B2 Mycobacterium sp. JLS
ZP_01275530.1
89% to CYP142B1 Mycobacterium vanbaalenii
46% to 142A5
MTTVFPETTH GDIDLSAREF WAKPPVERDA AFAVLRRENP VAWSRPADSD LLPPEQNLKG
FWSLTKHEDI RYASRHPEIF SSAQGITMED FPHEILMMSQ SFIAMDAPRH TQLRGITLDA
FKPRNMRRLQ GWVQEHARDL ISEMSHLGEG DFVELVSVKL PGRIFGSFFG LPPGEIHEKT
IDAAQRTLGW TDPDVRGDRT ALELFAGAVM DLHETVTTLL PERRANPGDD LLSWMVQAEF
DGVKMTDDEL KAFFTLLAVA ANDTTRHASA QAIYAFSQFP DQRDLLVADV EGRVDSAVEE
ALRWASPLIH MRRTATQDVT VRGAEIKAGD KVVLWYSSAN RDEDVFDDPF TFDIERNPNP
HLAFGGGGPH FCLGAALART MLRSLLTEVY TRIPDIHAPE PKFQVANFIN GINSLPATWT
PERR
CYP143A1 Mycobacterium tuberculosis
GenEMBL AL022021
Rv1785c
CYP143A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome complement(2013905..2015086)
Gene = cyp143A1 100% match
locus_tag = Mb1813c
CYP143A2P Mycobacterium leprae
GenPept CAC30494
NC_002677 1861010..1862160
locus_tag = ML1542
P450 pseudogene
Sequence below is from TIGR primary nucleotide sequence for ML1542
55% to CYP143 Mycobacterium tuberculosis Rv1785c
1 MSTSAKANPTHFTYCSLNYSALSMITDRGVIWKTLXX 105
113 AKPVVFMNG*YYLNVSRKCILHTTSITKGFSSREAXXX 217
225 PGNALPVLPXXXXXXXXXXXXXXXXXXX 251
278 SLNNLNKALPALRTYTVTMANAITSRGEW 364
366 EAMTDFANX 389
391 LFPLQLFLVL*GLXX 429
434 AQDRDHLIALLKDVVIGMSDKPFLSQADIADQGELCEYLVDTIAERKQNPA 586
585 PDVLSQVLIGEDPLSEIKVLDLESL 659
659 MLILAELDTVTATVGFSLLQPACRQQLRTMLRDKPKQIRILIED 790
792 ILQLEPPAQITPYITTEFVNVDGMTLSPGSRVRLC 896
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
993 GSHLARLKLTLAVDEWLINI 1052
XXXXXXXXXXXXXXXXXX
1116 LFALKALALHW 1148
CYP143A3 Mycobacterium marinum
No accession number
Tim Stinear
MM2631
60% to 143A1
CYP143A3 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 143A3 M. marinum = ortholog
CYP143A4 Mycobacterium marinum
No accession number
Tim Stinear
MM2666
75% to 143A1, 53% to 143A3
CYP143A4 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 143A4 M. marinum = ortholog
CYP143A5 Mycobacterium vanbaalenii PYR-1
ZP_01203645.1, EAS24637.1
59% to 143A1
MSALPHVLYGDLPMAADRGAGWATLREFGPVAYGDGWYYLTRRDDVLAALRNPEVFSSRIAYDDMISPVP LVPLGFDPPEHTRYRRILHPFFSPQALGVLLPSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLTLF GLPLQDRERLIAWKDAIIAFSLTNDPTSVDLTPAVELYGYLTEAVARQREKPREGILSHLLHGDEQLTDN EAVGLSLVFVLAGLDTVTSTIGATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREV TVAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLDGKLHKHWGFGGGPHRCLGSHLARMELRLVVTEWL SRIPDFELAPGYVPEITWPSATCTLPTLPLILTRKTP
CYP143B1 Frankia alni ACN14a
YP_713572.1
CAJ62007.1
47% to CYP143A1 Mycobacterium tuberculosis
MSAGEAQPLTFEDLPVRDDRDAAWRLIRERGGIVQLEPDVALTDHTLVEAAFRNPAVFSSRQAFDSLGSP
LPLVPIAFDPPEHARYRHILQPFFSPRSIRPLEPELRRQLAELIAPLPARGACDFVADVASVFPVQAFLT
FFGLPLDMRDQFVAWKDAILALSDPSGAISTDEADLRHAGELFTYLSELVAARRGVPGPDVLSELLCLDG
DDALTDAEVIGLCFLFVLAGLDTVTDALGFGMERLARNPDRRQEIVDDPGLVPAAVEELLRLDPPAPFVP
RITTAQTELGGRTLPAGTRVTAYIAACNRDEARYPDPYGVDFHRGDNPHASFGVGVHRCLGSHLARLEMR
LVYEEWHRLIPHYDIAPGFAPTVKFPRGTVGLEALPLVLTPGASR
CYP143B2 Frankia alni ACN14a
YP_715649.1
CAJ64123.1
45% to CYP143A3 Mycobacterium marinum
MTHKRDMRHSASHAWNESWVTRRAGERVEGTAMTDDRNNEKVTLSNLPIARDRDAAWRQLREHGRTVLLD
GGLAATDVETVETVLRQPAIFSSKKAFDVLGSPLPLVPIAFDPPDQTRYRRILQPFFSPRAIRPLEDELR
RQIVEIVEPLVRRGSCEYVSEVAGIFPVQVFLTLFGLPLEMRDQFIEWKDAILGLSDPSGNTALDEAATE
AAMATALGLFSYLADLVPARRGVAGDDVLSQLLCLEGDEALTDEEAVGLCFLFVLAGLDTVVDALSFGTD
RLIRNPDRRREIVDDPALIPAAIEELLRLDPPAPFVPRVTTEQTVLDGRTLPAGTRVTTNLAAANRDPAR
HPDPYTVNFHRGESPHLSFGAGVHRCLGSHLARLEMRLVFEEWHRLIPDYDLAPGASPQVKWPRGTLGLD
ALPLVFPASAPAAGAGGQAS
CYP143C1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7215
51% to CYP143B2 Frankia alni ACN14a
CYP144A1 Mycobacterium tuberculosis
GenEMBL Z97345
Rv1777
CYP144A1 Mycobacterium bovis subsp. bovis AF2122/97,
NC_002945 complete genome 2001114..2002418
Gene = cyp144 1 aa diff
locus_tag = Mb1806
CYP144A1P Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha02971
Submitted to nomenclature committee 12/13/04
57% to 144A1
CYP144A2 Mycobacterium smegmatis MC2
MSMEG0667 TIGR
67% to CYP144A1
59% to CYP144A3 Mycobacterium vanbaalenii
MTFGCMTPPEGLGLALFRPECIQDPYPLYRRMLDTAPVHPIADSGFYAVC
GWDAVNDAIARPENFSSNLTATMTYQADGTVGAFEMESLGGKSHVLATAD
EPAHTAHRKALLPQLAARRIRAFEPFILETANSLWHSHLHDGHIEWMSAV
ANRLPMMIVGRLIGVPDADVDKLVRWGYSATQVVEGLVGQDQLTQATVAV
MELAGYITDQFRHAAQDPQDNLLGDLATACATGEMDELTAQSMMIILFSA
GGESTASLIGSAAWILASRPDIQEHLRAKPELLGAFVEEVLRYEPPFRGH
YRHVVHDTTLGGVDLPAGSRLLLLWGAANRDPSHFDAPDEFRLDRSSAKS
HLSFGKGTHFCVGAALARLEALVVLRHLLHNTANITAGDTGPWLPSLLVR
RLAHLELVTT
CYP144A3 Mycobacterium vanbaalenii PYR-1
ZP_01207741.1, EAS22731.1
60% to 144A1
MTVGHTDLGLALFHDEFLQDPHPLYARMHAEAPVHRVGDSDFYAVCGWDAITEAVARPGDFSSNLTGAMR YQADGTVSLLPLDTLGSPTQALATADDPAHAAHRKLLVPYLAAKRVRALETFAENTMHALWQQMPAGAPV EWMAVVADRLPMTVVCKLIGVPAEDVDRIAAWAYASTQILEGRVDEHTLTAAGTAALELAGYISDKLGRA SLDPGDNLLGCIATACAAGELNNLTAQVMLVTLFSAGGESTAALIGSATQIIATRPDVQRRLRADPGLIP AFLEEVLRFEPPFRGHYRHVVRDCALAGKELTAGSRLLLLWGAANRDPARFDAPNEFQIERPNSKAHIAF GKGAHFCIGAALARFEARIVIDLLLRHTSWVDAAGPGWWLPSLLVRRLDELPLTMT
CYP144A4 Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 144A2 M. marinum = ortholog
formerly 144A2 but that name waws already assigned to
a Mycobacterium smegmatis seq (my error)
CYP144A4 Mycobacterium marinum
No accession number
Tim Stinear
MM2654
80% to 144A1
formerly 144A2 but that name waws already assigned to
a Mycobacterium smegmatis seq (my error)
CYP145A1 Nocardioides sp.
GenEMBL AB000735
gene for 2-carboxybenzal
CYP145B1 Streptomyces scabies
SCAB90301
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
47% to CYP145A1 AB000735 Nocardioides sp.
CYP145C1 Streptomyces scabies
SCAB90701
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
44% to CYP217A1 Thermobifida fusca GenEMBL NZ_AAAQ01000029b
42% to to CYP145A1 AB000735 Nocardioides sp.
Change CYP217A1 to CYP145
CYP146A1 Amycolatopsis orientalis
GenEMBL AJ223998
cosmid PCZA361 (gene 2 of 2)
CYP146A2 Amycolatopsis balhimycina
biosynthetic gene cluster for balhimycin,
strain DSM 5908.
Y16952.3
90% to CYP146A1
MFEESNALRGTEIHRRDRFAPGPELRSLMGEGTMSILQPPDSPG
GRTGWLATGHDEVRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMVTS
AFTVRRMQDFRPRIEQIVQASLDAIEAAGGPVDFVPRFAWSVATTVTCDFLGIPRDDQ
ADLSRALHASRSERSGKRRVAAGNKYWTYMTEIAARARRDPGDDMFGAVVRDHGDAIT
DAELLGVAAFVMGAGGDQVARFLAAGAWLMVEHPDQFALLREKPDTVPDWLNEVERYL
TSDEKTTPRIAQEDVRIGDQLVKAGDAVTCSLLAANRRKFPAPEDEFDITRERPVHVT
FGHGIHHCLGRPLAEMVFRAAIPALAQRFPKLRLAEPDREIKLGPPPFDVEALLLEW
CYP147A1 Myxococcus xanthus Partial missing C-term
GenEMBL AF111947 CDS 1939..>2877
42% to AF087022 partial new family
CYP147B1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV584 50% to 147A1 from Myxococcus xanthus
(147A1 is missing C-term so could be higher % identity)
CYP147B2 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05428
Submitted to nomenclature committee 12/13/04
55% to 147B1, 57% to 147E1 (partial seq)
CYP147C1 Streptomyces tubercidicus strain I-1529
No accession number
Istvan Molnar, Syngenta Biotechnology, Inc.
Submitted to nomenclature committee June 2, 2003
Clone name CypEA
50% to 147A1
CYP147D1 Magnetospirillum magnetotacticum
GenEMBL NZ_AAAP01002628
complement(814..1824) gene = Magn3224
N-terminal is about 61 aa short
51% to 147B1 44% to 147C1
MCAPGPGRDPQCGTGRSSSGDPPDHDRLRGQVMRCFTPQRVRGM
REKTRRITDDLIAKMAGKTRIDLVDDFSYPLPVTVICELLGVPPEDEAQFHGWATQLA
TALEPNQRGDEETQAKNEVCFNEIADYIQGLIKEKRKNPQEDILSDLATDTDGMNDFD
LIATAVLLLVAGHETTVNLITNGMLTLLRFPEHLERLRAEPETAPRLIEELLRYEPPV
HYRTRLALADIPVAGITIPKDAPVILLLAAANRDPLRFSDPDRFDPDRPDNRHLGFGG
GLHYCVGAPLARIEAEVALVSLVRRLKGLSLTENPPPYRPGASLRGPCHLRLALEEVA
EG
CYP147E1 Methanosarcina barkeri Archaea; Euryarchaeota
GenEMBL NZ_AAAR01001943 4935..6305
52% to 147D1 probable lateral transfer
gene = Meth3340
MYRQGSGPNDRRQTMTQQSLYEQVLDYANRANPYPLYAKLRQTP
ITRQIDGSYVVSTYREIVSLLHDPRIGSDFRMRSA
HDRPSAGLSANQELASKNQAQDEGAETSSSNQGSETEVV
PSFIGLDPPEHDRLRRQATWPFGPPHTPGRVADMEPELILLA
NRQIDTIKGRTSIDIVEDFAYPIPVTMISELLGVPPEDQPRLHALSEAIIEDIDLDPR
QSPEEQKRRQEQSSQTFKELEQYMEVLIEHHRKQPGSDLLSGLITDHGSDGPMAQADL
VSTASLLLIAGHETTVNLITNGMLTLLRHPDVLERLRREPDLVIRLVEEFLRYEPPVQ
ILPNRVALSDITIAGTTIQKGSPVILLLASGSRDPARFHDPEKFDPDRRDNMHLGFGS
GIHYCYGAPLARLETQIALTELVQRLENPRLAHDPPPYRQSATLRGPRHLIVEIDGVK
DWEFHL
CYP147E1 Methanosarcina barkeri str. Fusaro (Euryarchaeota; Methanomicrobia)
YP_305464, AAZ70884 GenPept, NC_007355 chr 1,
complement(2430095..2431423),
1 MTQQSLYEQV LDYANRANPY PLYAKLRQTP ITRQIDGSYV VSTYREIVSL LHDPRIGSDF
61 RMRSAHDRPS AGLSANQELA SKNQAQDEGA ETSSSNQGSE TEVVPSFIGL DPPEHDRLRR
121 QATWPFGPPH TPGRVADMEP ELILLANRQI DTIKGRTSID IVEDFAYPIP VTMISELLGV
181 PPEDQPRLHA LSEAIIEDID LDPRQSPEEQ KRRQEQSSQT FKELEQYMEV LIEHHRKQPG
241 SDLLSGLITD HGSDGPMAQA DLVSTASLLL IAGHETTVNL ITNGMLTLLR HPDVLERLRR
301 EPDLVIRLVE EFLRYEPPVQ ILPNRVALSD ITIAGTTIQK GSPVILLLAS GSRDPARFHD
361 PEKFDPDRRD NMHLGFGSGI HYCYGAPLAR LETQIALTEL VQRLENPRLA HDPPPYRQSA
421 TLRGPRHLIV EIDGVKDWEF HL
CYP147F1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
55% to 147B1 if 9 aa removed, 54% to 147E1
clone name SP0549
CYP147F2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7351
57% to CYP147F1 Streptomyces peucetius
60% to CYP147F3 Streptomyces bingchenggensis
CYP147F3 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9076
68% to CYP147F1 Streptomyces peucetius
60% to CYP147F2 Streptomyces bingchenggensis
CYP147F4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY4255 73% to CYP147F1
CYP147G1 Mycobacterium marinum
No accession number
Tim Stinear
MM2930
41% to 147B1 41% to 147E1 45% to 147A1
CYP147G2 Mycobacterium vanbaalenii PYR-1
ZP_01203548.1, EAS24540.1
44% to 147E1, 69% to 147G1
MTTASQAWAQAMAFAHRADPYPFFAELRKTPVARVADDLYVVTGYYELLALAHDPRVSSDFRRSPLSSDR APAEPADDVGAYGSEPSLIVTDPPSHDRARRQVSRHFAPPHSPDLIPSMEPAVVALCNDLLDTAKANGRT RIDVVDDYAYPVPVMVICKILGVPLEDEPRFHAWIFDMLAGVDLGPDATTDEGQGRAARARDAQAALRDY LAGLIEGYRGAGGDGLLSALVNDASGPDGAMPPGQALANAVLLLIAGHDSTVNTISNCVLTFLRNPGTVE LLRDRPELIPRAIEEVQRLQSAVQFFPSRSATADIEVGGTVIPEGAAVHLMYGAANRDPRRFADPDTFDI FRPDNEHFGWGSGIHTCVGGPLARLEVNLALEIFLRRVHRPRLVSDPPPYRQSQIFRGPRHVLVDVEAIG D
CYP140H1P Frankia sp. EAN1pec
YP_001510211.1
ABW15305.1
58% to CYP147B2 Rhodococcus sp. RHA1 I-helix
MAELAAKRHDAPRDHMLSGLVSDDGPQGRMSQAEPITTAILLFVAGHETTVDLITDGMLIFLRHPELLEW
MRREPDLMAGAVEELLRYEPPVHMLPQRTTLTDVEIAGTTIPRALRSP
CYP147J1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE7364 46% to CYP147F1
CYP148A1 Deinococcus radiodurans R1
GenEMBL AE002083 CDS 1719..2948
38% to AL049754 complement(10413..11648)
CYP148A1 Deinococcus radiodurans
GenPept AAF12079
GenEMBL NC_001263 2539498..2540727
Gene = DR2538
1 MTASSGSSAP SSGPLLAAVQ GLWSGAALAD PHPIYEQIRG FANADGLVRL PEWNTAFAVG
61 HAATSAVLRS PAARSGEWDH GPSDGGKLLQ HMMLFRNGIP HARLRGLVQK AFTPRVVEEQ
121 RDLVRSLLDE LLSDMARAGG PVDLVAGLSG PLPGRVIMRM LGLRGADEER FLGWSASVAE
181 LLGGADRSPA LLARIEADAR EMRGYFRDLA DELRVSPQPG LLSALAAVED GGERLSGDEL
241 LSNAVLLLAA GHETTSNLIP GGVLALSQQP GAWAALLNHP RHPGVADELL RHVSPVQLDG
301 RMLTEAQTVG ETPLPAGTPV QLLLAAANRD PQVFPDPERL DWDRPNASRH LAFAAGPHYC
361 LGASLARLEI AETFAALAER FPDLRVSAAP HYKANFVLRG PQELWVTLG
CYP149A1 Microcystis aeruginosa
GenEMBL AB036790 CDS complement(779..2254)
gene="mapks"
41% to 107H1 partial seq new family
46% to CYP1011A1 C-term
note="In CYP149A1 the amino acid residues 2 to 200 are similar to
polyketide synthase
The amino acid residues 217 to 502 are similar to
cytochrome P450.
CYP150A1 Mycobacterium species
GenEMBL AF107046
Pascal Poupin
gene 1
CYP150A2 Mycobacterium smegmatis mc2155
GenEMBL AF107047 1092..2405
MSMEG4769 TIGR
Pascal Poupin
gene 2
61% to 150A4, 57% to 150A3, 82% to 150A1
84% to CYP150A7 Mycobacterium vanbaalenii
60% to CYP150A8 Mycobacterium vanbaalenii
58% to CYP150A9 Mycobacterium vanbaalenii
56% to CYP150A10 Mycobacterium vanbaalenii
MTDSTATDPAATTPDFDTVDYFTDQSLVPDPHPYFDHLRSKCPV
VREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPFPPLPFTPEGDDITGQIEQHRT
QLPMFEHMVTMDPPEHTNARSLLNRLLTPKRLKENEDFMWRLADECLDDFIDDGSCEF
LKQYAKPFSLLVIADLLGVPEEDHDEFRHVLGAPRPGAIVGSLDGDQLAMNPLAWLDD
KFVRYLEDRRKEPRDDVLTALATAKYPDGSTPEVIDVVRSATFLFAAGQETTTKLLSA
SLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAKKTTQLGGVDVPAGT
TLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSLER
ILDRMADIRIDEEHHGPADNRRYTYEPTYILRGLTDLHIKFEPVR
CYP150A3 Mycobacterium smegmatis
MSMEG4812 TIGR has extra seq (lower case)
but this may not be real protein seq
56% to CYP150A1 47% to CYP150A4
56% to 150A2
74% to CYP150A9 Mycobacterium vanbaalenii
62% to CYP150A10 Mycobacterium vanbaalenii
55% to CYP150A7 Mycobacterium vanbaalenii
mtakrrcgnvilnnerhvlirlspsgngvth
MAIDPAGIDWFKDPRLVDDPYPYFNALRDKCPVQSEDHYGVTMVTGWEEA
VSVYNDEKSFSSCTSVTGPFPGFPVPLEGRDDVAELIEKHRDELPFSDQL
PTLDPPVHTNHRSLMMRLITPKRLKENEDAMWQLADEVLDDFLAPGKGEF
IKGFASPFTLLVIADLLGIPAEDRNAFVDGISQNSGGGVGSTGDESLSHS
PLEFLYGQFEAYIEDRRSNPREDILTGMATALFPDGTTPSPGDVARVATN
VFSAGQETTVRLLGTALKVLGDRPDVQKMVREDRSLLPNFIEEALRHESP
VKGDFRLSRCPVTVGDKDLPSGRTVMVVNGAANRDPRRFENPDDFDPARK
NARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTTDIRISEEHHGPAA
NRDYKYIPTFILRGLTHLHLEFDVK
CYP150A4 Mycobacterium smegmatis
MSMEG5988 TIGR
61% to CYP150A2
47% to CYP150A3
81% to CYP150A8 Mycobacterium vanbaalenii
61% to CYP150A7 Mycobacterium vanbaalenii
49% to CYP150A10 Mycobacterium vanbaalenii
51% to CYP150A9 Mycobacterium vanbaalenii
MTDLASVDYFSDPAVAQDPYEYYDFLRSRGPVTTEPHYGVVAVTGYQEVM
AAFKDHDSFSAVNAIGGPFPPLPFTPEGDDITEQIEAHRHLFPIHEHMVV
MDPPAHERARSLLSKLLTPRRLKENEDFMWQLVDRQLDAIIGNQADEGRC
EFLSEYAKPFATSAIIDLLGVPEEDRAEFLEALGAAPREGARVGALDGEP
VGLDPLQYLDCKFAGYLAERRREPRGDVLSGMATATYPDGSTPDLMEVVK
PATFLFAAGQETVTKLLSSAVQTLAERPEFQERLRKEPDLIPVFIEEALR
TQSPTKVDFRLARKTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFR
IDRPNVREHIAFGRGIHTCAGAPLARVEGQITVRRMLDRLRDIRIDATRH
GPADSRTYAYEPTFLLRGLTKLHIEYTPA
CYP150A5 Mycobacterium marinum
No accession number
Tim Stinear
MM4737
57% to 150A2
formerly CYP150A3 but this name was already assigned to
an M. smegmatis seq (my error)
CYP150A6 Mycobacterium marinum
No accession number
Tim Stinear
MM4694
97% to 150A6 M. ulcerans
CYP150A6 Mycobacterium ulcerans
No accession number
Tim Stinear
70% to 150A2 M. smegmatis, 55% to 150A3 M. marinum
formerly CYP150A4 but this name was already assigned to
an M. smegmatis seq (my error)
CYP150A7 Mycobacterium vanbaalenii PYR-1
ZP_01205741.1, AAS77249.1, EAS26733.1
91% TO CYP150A1 Mycobacterium species
MSDFDTIDYFTDPSLVPDPHPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPFP PLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDI ISRDPVGRCEFLSAYAKPFSLLVIADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANPLEWLDE KFIGYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASLRVLGDHPDIQ ERLRRDRSRIPIFVEEALRMDAPVKSQFRLAKKNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDL DRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPTFILRGLTD LNITFTPVR
CYP150A8 Mycobacterium vanbaalenii PYR-1
ZP_01207544.1, EAS23103.1
60% to 150A2
MTDLASADFFSDYALSQDPHPYWDHLREQNPVYREPHYGVVAVTGYQEVLAAFKDHDSFSAVNAIGGPFP PLPFTPEGDDITEQIEAHRHLFPIHEHLVVMDPPAHERARSLLNKLLTPRRLKENEDYMWQLVDSQIDQV IGKGRCEFLSEYAKPFATSAIIDLLGVPEEDRPEFLAALGAEQPDGARVGALDGEPVGLDPLQYLDDKFA GYLAERRREPRGDVLSGMATAVYPDGSTPELIEVVKPATFLFAAGQETVTKLLSAAVKTLAEQPEYQRIL RAHPDRIPTFIEESLRMNAPTKVDFRLVRKTTTLGGVHLKAGTIVMLCLGAANRDPRKFEDPHEFRPERK NVREHIAFGRGIHTCAGAPLARVEGQITVRRWLDRTDEIHLDESVHGPAGQHHFAYDPTFLLRGLSQLNI EFTAAT
CYP150A9 Mycobacterium vanbaalenii PYR-1
ZP_01205777.1, EAS26769.1
58% to 150A2
MAEDLTTVDFFRDSRLTDDPYTFYEALRNKCPVSREEHYGVTMVTGWQEAVDVYNDAESFSSCVSVTGPF PGFPVSLEGRQDDDITALIEQHRDEIPFSDQLPTLDPPTHTNHRALLMRLITPKRLKENEDAMWQLADDI LDDYLAQGEGEFIKGFAGPFTLRVIADLLGVPEEDRPELLERLAKGTHGGGLGNADKTLTKTPLEYLYDV FATYVEERRAEPRDDVLTGLATANFPDGTVPEVGDVVRVATNVFSAGQETTVRLLSTALKVIGDRPDIQE RLRADRSLLPNFIEECLRIESPVKGDFRLSRVPTTIGDQALGAGCTVMVINGAANRDPRRFEDPDAFDPE RKNARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTSDIRISESKHGPAGNRRYDYIPTYILRGLTEL HLEYDVR
CYP150A10 Mycobacterium vanbaalenii PYR-1
ZP_01205906.1, EAS26898.1
55% to 150A2
MTEQLTPTDIDEVDFFTDNTVLHDPYGYLAAMRNECPVRRERHHDVVMITGYEEAVAVYNDNARFSSCTA VTGPFPGFPVPLVGDDVSGLIAEHRDKLPFNDQLPTLDPPLHTDHRALLSRMITPKRLKENEEFMWRLAD RQYDEALAGGRCEFVGEFGNPFAMLVIADLLGVPESDHNDFKDQLLTSTGTIGSSGGDAMHHSPLEYLYG KFTDYITDRRENPRDDVLTGLASALFPDGRTPPVIDVVCVAANLFAAGQETTVRLLSTAVMMIAEDPALQ AKLRADRSLIPGFVEEALRFESPIRGDFRLSKVPVSVGGVELPAGTTVMLNNAAANRDPRRFTDPDTFDL QRPNARQHIAFGRGAHSCPGAPLARAEAKVSINRLLDRTSDIWIDEDKHGPVDARRYKYLPTFILRGLTR LHIEFS
CYP150A11 Frankia sp. EAN1pec
YP_001508962.1
ABW14056.1
71% to CYP150A3 Mycobacterium smegmatis
MREFEAMDFFRDETLVADPYPYLDALRRKCPVQRERHHDVVMVTGYEEAVEVFHDSEAFSSCVSVTGPFP
GFPVPLDGDDVSALIERHRHELPMNDQLPTMDPPTHTDHRALLMRLITPKRLKENEALMWDLADRMLDPF
LTPGEGEFISGFAGPFTLLVIADLLGVPEEDQDEFLDKLQRQPAQTGGVGGTGAETLAHSPLEFLYGKFT
GYIEDRRRNPRADVLTGLAGATFPDGSTPEVIDVVRVAANLFSAGQETTVRLLSSALKILAERPDLQRQL
RVERERIPAFIEETLRWESPVKGDFRLSRVPVTVGGVQLPAGTTVMVVNGAANRDPRRFENPETFDVARS
NARQHLAFGRGIHSCPGAPLARAEARASLERLLDRTTDIRVNERVHGPAGNRRYEYMPTFILRGLTALHL
EFDLAPAPPRDFPPAGSPVGWIKG
CYP150A12 Frankia sp. EAN1pec
YP_001508233.1
ABW13327.1
69% to CYP150A5 Mycobacterium marinum
MSELETKDFFRDEELVADPYPFLEAMRGKCPVQRENHHDVVMVTGYDEAVQVFHDSATFSSCVSVTGPFP
GFPVPLEGDDVTELIERHRGELPMNDQLPTLDPPTHTAHRALLMRLITPKRLKENEAQMWRLVDQMVEPY
LAGGEGEFITGFAGPFTLLVIADLLGVPEEDQEEFLDRLQRQPQESGGIGSTGDDHMAHNPLEFLYNKFT
AYIEDRRREPREDVLTGLALATFPDGSTPEVIDAVRVAANLFSAGQETTVRLLSSALKILAEDRELQQLL
RAEPDRVGNFIEETLRLESPVKGDFRLSRVPTTVGGVDLPAGTTVMVVNGAANRDPRRFENPSVFDVARP
NARHHVAFGRGIHTCPGAPLARAEARASIERLLERTTDIRISESVHGPADDRRYSYLPTFILRGLTHLNL
EFTLAESKTP
CYP150A13 Frankia sp. EAN1pec
YP_001507995.1
ABW13089.1
69% to CYP150A5 Mycobacterium marinum
MKDIEAIDFFRGDELVADPYPYFHALREQCPVRREPHHGVVMVTGYEEAVSVFHDSDRFSSCTSVTGPFP
GFPVPLEGLEGDDISELIERHRAELPMSDQLPTFDPPMHTDHRALLMRLITPKRLKENEEFIWRLADRLL
DEYLASGEGEFIRGFAGPFALLVIADLLGVPEEDHEEFTDRLQHRPAEGGGVGSTGDHSMEHSPLQFLYD
RFTTYIEDRRREPRDDVLTGLATATFPDGSTPEVIDVVRVAANLFSAGQETTVRLVSTAAKLIADNPGLQ
RLLRAERDRIPNFIEETLRLESPVKGDFRLARVPTTVGGVDIPAGSTVMVVNGAANRDPRRFADPDTLDV
ARPNARQHIAFGRGIHSCPGAPLARAEARAGLERLLDRTADIRISERVHGPAGARNYQYLPTFILRGLTH
LQLEFTPAASDSR
CYP150A14 Frankia sp. EAN1pec
YP_001504962.1
ABW10056.1
60% to CYP150A2 Mycobacterium smegmatis
MTDWTTTDFFNDESLAEDPYPYFDELRSVCPVLPLPHLGVVAVTGYDEAHEVYRDVDTFSSCNSVVGPFA
TFPVPLEGDEVGAIIDRHRDQLPMNEHMVTMDPPMHTRERALVMRMLTPKRLQENEAFIWRLADQQLDEF
IADGRCEFIRAYAQPFSMLAVADVLGVLESDHQRFREGFGLTVSPGQIGAGEQTDGELNALGWLDAWFAR
YIESRRHEPRNDVLTQMAAATYPDGTTPEVTSVVRAATFLFAAGQETTARLLGAALKFIAENPGLQEEIR
EHRERIPDLIEETLRVESPVKADFRLARRTTTIGDVEVPAGTPVMLLNGAANRDPRQFECPAEFRISRRN
VRQHIAFGRGIHSCPGGPLARVEGRISLERILDRTRDIRISEEHHGPPDARRFDYEPTWILRGLTNLHLE
FTPVESAR
CYP150A15P Frankia sp. EAN1pec
YP_001505067.1
ABW10161.1
59% to CYP150A2 Mycobacterium smegmatis
MSDWKTIDYFTDESLVADPYPYFDELREAGPVLPLPHLGMVAVTGYEEASQVYREAETFSSCSSVVGPFA
TFPVPLEGDDVSEIIDRYRTRLPMFEHMVTMDPPDHTRERALLMRLLTPRRLKENERFISRQADRQLDEF
IDRGTCEFVREYAQPFTMTGPLTSGCPKSTTGRRVPGVSPTTPPGSCAA
CYP150A16 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
66% to CYP150A12 Frankia sp. EAN1pec
CYP151A1 Mycobacterium smegmatis
GenEMBL AF102510
Poupin P, Ducrocq V, Hallier-Soulier S, Truffaut N
Cloning and Characterization of the Genes Encoding a Cytochrome
P450 (PipA) Involved in Piperidine and Pyrrolidine Utilization and
Its Regulatory Protein (PipR) in Mycobacterium smegmatis mc2155.
J Bacteriol 181, 3419-3426 1999
CYP151A2 Mycobacterium sp. strain RP1
GenEMBL AJ310142
Pascal Poupin
Submitted to nomenclature committee March 22, 2001
86% identity in 399 aa overlap with CYP151A1
CYP151A3 Mycobacterium vanbaalenii PYR-1
ZP_01205617.1, AAS49915.1, EAS26609.1
88% TO CYP151A1 Mycobacterium smegmatis
MSSATVGSVPAFAVTDPGFSITSAEVHAARERSWYATTEYGLAVLRYEQVNRLLKHPKLRQGSAAWPAHN GVTEGPFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRFQALAAELIDGFAEPGRCEFVGEFA EPYAARVIAIMLGLPESEWKVIATESATIGLALGVTILDDLPRIEAALAHLYEYCDELIADRRASPRDDF VTTLVNASRPEDGRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGNAVEEV MRVNPTVRWVTREVLEDFEYEGVELAAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGVHHCLG HFVARSDMSEALPLLARRMLDPHELPGATWLPDSGNTGPITLPIGFTPAS
CYP152A1 Bacillus subtilis
GenEMBL AB006424
ybdT gene
this sequence is missing part of the heme signature sequence, but has
PERF and EXXR
CYP152A2 Clostridium acetobutylicum
GenPept AAK81262
YBDT B.subtilis ortholog
59% to 152A1
1 MLLKENTAKD KGIDSTLDLL KEGYLFIKNR ADHYQSDLFE TRLMGQRIIC MTGEEAARIF
61 YDSDKFKRQG AAPKRVQETL LGENAIQTLD GESHLHRKKL FMLLTNQVQQ KRLAELTTEK
121 WEASASKWHT KSIVLFNEAN EILCQVACHW AGVPLMESDI KNRAEDFSSM IDSFGAVGPR
181 HWKGKKARNT IEAWIKEIIE NVRSGRIRAE EGSPLHEIAF YIDVNGQQMP AEMAAIELIN
241 ILRPIVAIST FITFSALALY EHSEYREKLQ SKDIRYLEMF TQEVRRYYPF APFVGARVRK
301 DFLWNNCEFK KEMLVLLDIY GTNHDSRIWQ KPYEFIPDRF RSYKGNLFDF IPQGGGDPSS
361 THRCPGEGIT LEIMKTSLDF LSTKIDFTVP DQDLSYSLSK IPTLPKSGFI IDNINLKL
Note on Clostridium acetobutylicum.
This organism is classed as an obligate anaerobe, however the article below
Shows that it grew well in a microoxic environment and peptides were induced
Within 10 minutes of exposure to oxygen.
Kawasaki S, Ishikura J, Watamura Y, Niimura Y.
Identification of O2-induced peptides in an obligatory anaerobe, Clostridium
acetobutylicum. FEBS Lett. 2004 Jul 30;571(1-3):21-5.
Furthermore, all three classes of ribonucleotide reductase are present
In the genome.
Torrents E, Aloy P, Gibert I, Rodriguez-Trelles F.
Ribonucleotide reductases: divergent evolution of an ancient enzyme.
J Mol Evol. 2002 Aug;55(2):138-52.
Class I RNR absolutely requires oxygen to generate a free radical on Cys.
Class III is poisoned by oxygen and class II can work either way.
The P450 in an anaerobe is odd, but the CYP152A1 is a peroxygenase not
A monooxygenase, so CYP152A2 is also expected to be a peroxygenase.
The other facts mentioned above may suggest C. acetobutylicum is not
Completely unable to be exposed to oxygen. The P450 might serve a protective
role, or it may be an oxygen sensor, producing a signaling molecule in response to
oxygen/hydrogen peroxide. Alternatively, it may have recently become an anaerobe
and still has oxygen metabolic enzymes left over from an aerobic past.
CYP152A3 Clostridium lentocellum DSM 5427
GenEMBL YP_004308874
58% to CYP152A1 Bacillus subtilis
CYP152A4 Bacillus amyloliquefaciens FZB42
YP_001420702.1
70% to CYP152A1 Bacillus subtilis
CYP152A5 Clostridium botulinum A2 str. Kyoto
YP_002803405.1
68% to CYP152A2 Clostridium acetobutylicum
CYP152A6 Bacillus halodurans C-125
NP_242623.1
57% to CYP152A1 Bacillus subtilis
CYP152A7 Clostridium phytofermentans ISDg
YP_001560008.1
68% to CYP152A3 Clostridium lentocellum DSM 5427
CYP152B1 Sphingomonas paucimobilis
GenEMBL AB006957
Isamu Matsunaga
this sequence is missing part of the heme signature sequence, but has
PERF and EXXR
CYP152B2 Azotobacter vinelandii
NZ_AAAU02000007 102969-104183
56% to CYP152B1 with two frameshifts
may have 10 aa deletion after aa 136
MHRIPRDKGLDSTLALLHDPYRFIARRCRLHGSNLFETRLLLRKTLCMSGAEAARLFYDP
ERFVRHGAMPPRLQKTLFGVGGVQGLDGEAHRHRKHMFVALLMDAERVAQLVEAVRGEWR
TCARRWERMEKVVLYD
CAWAGIPLAEEEAGPRAREIALLFDYAGSVGPKHWRSRLARRRSEAWMGALVESIRASRR
QPPAETAAQVISWHRGLDGNLLEAR
VAAVELLNVIRPVVAIAVYLTFVAHALHRYPHCRHGLRSGDAEYREWFVQEVRRFYPFFPA
VVARVRQDFEWRGYAFPAGRRVMLDLYGTDHDVRLWQAPETFRPERFGSREYGPCDFIPQ
GGGEHESGHRCPGERIVMKLGADVLARELSYAVPMQNLEIDFSRLPALPRSRFVMSDIHGAP*
CYP152B3 Chelativorans sp. BNC1
YP_665837.1
58% to CYP152B1 Sphingomonas paucimobilis
58% to CYP152B2 Azotobacter vinelandii
82% to CYP152B4 Sphingopyxis alaskensis RB2256
CYP152B4 Sphingopyxis alaskensis RB2256
YP_617595.1
59% to CYP152B2 Azotobacter vinelandii
82% to CYP152B3 Chelativorans sp. BNC1
CYP152B5 Kytococcus sedentarius DSM 20547
YP_003150307.1
52% to CYP152B1 Sphingomonas paucimobilis
55% to CYP152B3 Chelativorans sp. BNC1
55% to CYP152B4 Sphingopyxis alaskensis RB2256
CYP152C1 Rhodobacter sphaeroides
GenEMBL NZ_AAAE01000129 complement(38633..39955)
gene = Rsph2136
also YP_352437.1, ABA78536.1
40% to 152A1, 41% to 152B1
MTTDEGRRPEEPGTPASLREMPRDPRIDASMALMSEGYRFVSNL
CDRMDSDAVATRLRLREVVCLRGSAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQ
LEGPAHRHRKALFLSICMDPARVEALVSEMRLAWRERLPAWEAEGRIVLQQEAARLLT
RAGCRWAGVAHQPEAQLADEIFDMIDKAGSVGPRNWLAQMRRAGTEKRLRTLVEEVRA
GEVVPEAATALHAIAFHREEDGTLLDPSVAAVELLNLLRPIVAVGRYITFAALALHRE
TTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPITWEGYDFPEGQWLLLDLY
GTTHDPRHFPEPTRFRAERMLSWTGQDEAFIPQGAGDVARTHRCPGEMITVELMKEAI
RLLCCEMDYEVPAQDLGVRLNRMPAQPRSGMILSAISRRAGTEASRNG
CYP152C2 Rhodobacter sphaeroides
ZP_00915817, EAP62861.1
78% to 152C1
MSNSDARHEA GPSDTTCGRE IPRDPRLDAS MGLLSEGYRF VSNLCDQLDS DIVSTRIRLR
EVICLRGGTA ARLLYGAEGL TRVGAMPSSV LHLLQDKGSV QQLEGPAHRH RKALFLGICM
DPARVEALVA EFRAAWRAAL DEWEEADSIV LQQEAARVLT RAACRWAGVE NQPEARLAEE
IFDMIDKAGS IGPRNWLAQM RRSGTERRLR KLIEQVRAGE VVPGSATALH AIAFHREADG
ALLDDTVAAV ELLNVLRPIV AVGRYITFTA LALHRETNWR DLFRSGTLEL AADFAEEVRR
ISPFFPFTAA VTTRPLQWEG YDLPADQWLL LDLYGTLHDA RNFPDPARFR AERMLSWSGQ
DDCFVPQGGG EVAVTHRCPG EMITVELLKE AIRLLCLEMD YEIPPQDLGV RLNRLPAQPR
TGMVLASIRR RPGTEPCVAG
CYP152D1 Streptomyces scabies
SCAB80661
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
42% to 152A1, 42% to 152B2, 39% to 152C1
CYP152E1 Cyanothece sp. CCY0110
ZP_01728364
MIKKIPQDKWIDSSLALIFDGYDFISKRCKRYQSNIFQTRLMLEKTICFKGEEAAKIFYDKTKFTRKNAA
PDRVKKTLFGEKGIQGMDGDAHLHRKQMFMSLMSKERIQEVGTLTQKQWHNYAKKWERMDTIVLFEEARE
VLCRVACTWAGVPLEESEVKLRSQQFEAMIAGSGVVGPKHWQGRKARKENEQWIETIIEKVRNHQLEVPE
ISATYIFANHRDLSGELLDKRVAAVELINVLRPIVAIDRYITFGALALHEHPECRPKLLESEDYLRAFVE
EIRRFYPFFPFASARVRQDFDWQGYHFPEGTRVLLDLYGTNRDPQSWDKHDVFYPERFLNFSELDSFKFI
PQGGGDYHTNHRCPGEWITIELLKVTMTFLIQSINYNVPKQDLRINHLKMPTVPASGFVIKNVNLC
CYP152F1 Rhodococcus sp. R04
AFAQ01001450 1011-2294 (-) strand
Riu Xue
Submitted to nomenclature committee Dec. 26, 2011
41% to CYP152D1 Streptomyces scabies
CYP152G1 Rhodopirellula baltica SH28
GenEMBL ZP_16052477
52% to CYP152B1 Sphingomonas paucimobilis
CYP152H1 Sporolactobacillus vineae DSM 21990
GenEMBL ZP_10970070
52% to CYP152A1 Bacillus subtilis
CYP152J1 Oceanobacillus iheyensis HTE831
GenEMBL NP_694023
41% to CYP152A3 Clostridium lentocellum DSM 5427
CYP152K1 Bacillus clausii KSM K16
GenPept BAD65574
53% to CYP152H1
CYP152L1 Jeotgalicoccus sp. ATCC 8456
E9NSU2_9STAP
Terminal olefin-forming fatty acid decarboxylase OleT
CYP152L2 Staphylococcus massiliensis S46
K9B6J8_9STAP
CYP152M1 Enterococcus faecium
NZ_AAAK01000185 complement(2963..4222)
Gene = Efae1119
36% to 152B1
formerly CYP241A1, name changed
MKEVPVVDIKITDLKKLYQKGYNMLEELRHEADAPVVKAKIFNK
EAITIYGSSAAKVFYDPRNFKRKGAMPKLVLKTLFGQGGVQTLDGAAHHHRKNIFMDL
MTPERMEDYHRILDKNLTQALEAQHGQFELFDLSKMVFFTSICEWAGINLSAISKDEV
EKLAEYQISMISGTFTSPIDHIKGVENRKKSEKWAQGLIEEARQNPVAGKENVALYAF
ANATDLDGQLLPLEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFSTL
QDPFIQEMRRYYPFFPMLPAISLKEVEVDGYRIPEGSWVILDLYGTDHDERTVEAPDS
FMIKRYVGKAKDISYKEEYEMIAQGGGNFRQMHRCAGEWITLHSLRVFSDQLVNKFEF
SVPEQDWTIPFNQFPTYPNSRALLYKN
CYP152N1 Exiguobacterium sp. AT1b
YP_002886666.1
48% to CYP152K1 Bacillus clausii KSM K16
44% to CYP152H1 Sporolactobacillus vineae DSM 21990
CYP152P1 Methylobacterium populi BJ001
YP_001923998.1
60% to CYP152P2 Methylobacterium sp. 4-46
45% to CYP152A1 Bacillus subtilis
CYP152P2 Methylobacterium sp. 4-46
YP_001771085.1
60% to CYP152P1 Methylobacterium populi BJ001
47% to CYP152H1 Sporolactobacillus vineae DSM 21990
CYP152Q1 Arthrobacter sp. AK-1
YP_001742037.1
44% to CYP152G1 Rhodopirellula baltica SH28
47% to CYP152C1 Rhodobacter sphaeroides
CYP152R1 Pseudomonas stutzeri A1501
YP_0011173755.1
47% to CYP152E1 Cyanothece sp. CCY0110
46% to CYP152G1 Rhodopirellula baltica SH28
CYP152S1 Methylobacillus flagellatus KT
YP_545551.1
49% to CYP152H1 Sporolactobacillus vineae DSM 21990
49% to CYP152E1 Cyanothece sp. CCY0110
CYP153A1 Acinetobacter calcoaceticus
GenEMBL AJ311718.1
MAIER; T; FOERSTER, H.H.; ASPERGER, O. AND HAHN, U.:
Cloning of an unusual 56 kDa-P450 from the n-alkane-assimilating
bacterium Acinetobacter calcoaceticus EB104.
Unpublished
32% identical to CYP111 58% to 153A7 57% to 153A2
trivial name P450EB104
MNSVAEIFEKITQTVTSTAADVATTVTDKVKSNEQFQTGKQFLHGQVTRFVPLHTQVRGIQWMQKAKFRVFNVQEFPAFIEQPIPEVATLALAEIDVSNPFLYKQKKWQSYFKRLRDEAPVHYQANSPFGAFWSVTRYDDIVYVDKNHEIFSAEPVIAIGNTPPGLDAEMFIAMDPPKHDVQRQAVQDVVAPKNLKELEGLIRLRVQGVLDQLPTDQPFDWVQNVSIELTARMLATLFDFPYEKRHKLVEWSDLMAGTAEATGGTVTNLDEIFDAAVDAAKHFAELWHRKAAQKSAGAEMGYDLISLMQSNEATKDLIYRPMEFMGNLVLLIVGGNDTTRNSMTGGVYALNLFPNEFVKLKNNPSLIPNMVSEIIRWQTPLAYMRRIAKQDVELNGQTIKKGDKVVMWYVSGNRDERVIERPDELIIDRKGARNHLSFGFGVHRCMGNRLAEMQLRILWEELLQRFENIEVLGEPEIVQSNFVRGYAKMMVKLTAKA
CYP153A2 Caulobacter crescentus CB15
GenPept AAK22050
NC_002696 complete genome 61849..63153
56% to 153A1
1 MMSQNTDPRE DLMSDGSIDL KADARARAYS IPLEDYHVAD PALFQADAMW PYFERLRKEA
61 PVHYSKGDEE VGPYWSVTRY NDIMTVDTTH QVFSSDAHLG GITIRNFDED FVLPMFIAMD
121 QPKHDIQRKT VSPIVSPANL GRLEGIIRER VCGILDALPI NEPFDWVDKV SIELTTQMLA
181 TLFDFPWEER RKLTRWSDIA TASPESGLIE SEEARRAELL ECLAYFTNLW NERVNLTEPG
241 NDLISMLAHG EATRDMPPME YLGNVILLIV GGNDTTRNSL TGGLYALSKN PQEEAKLRAD
301 PGLIPNMVSE IIRWQTPLAH MRRTALEDYE LAGQTIKKGD KVVMWYVSGN RDDTVIENAD
361 QFIVDRPNAR RHLSFGFGIH RCVGNRLAEM QLKIVWEEIL KRFPKIEVLE EPKRVYSTFV
421 KGYERMMVRI PERI
CYP153A3 Bradyrhizobium japonicum USDA 110
GenPept BAC52507
NC_004463 complete genome 7964879..7965991
51% to 153A1 70% to 153A4
FORMERLY CYP153B2 CYP153A and CYP153B have merged
1 MHYCKDSMFG PYWSVTRYND IMEIETNHSV FSSASALGGI TIRDIDPDLR RESFISMDPP
61 RHAAQRKTVA PMFTPTHLDN LALNIRARSA ECLDNLPRGE VFDWVDRVSI ELTTQMLAVL
121 FDFPWEDRRK LTRWSDIATT IPGPDGLVAT EDERQAELTE CAGYFARLWK ERIEQPPKSD
181 LLSMMAHGAA TRDMDAKNFL GNLVLLIVGG NDTTRNTMSG SIYALSQHPE QYRKLRENPA
241 LLDSFVPEVI RWQTPLAHMR RTALSDFEFR GKQIKKGDKV VMWYVSGNRD EEAIEKPYDF
301 IIDRARPRTH LSFGFGIHRC VGLRLAELQL KIIWEEILKR FDHIDVVGEP KRVYSSFVKG
361 LETLPVKIAA
CYP153A4 Bradyrhizobium japonicum USDA 110
GenPept BAC52508
NC_004463 complete genome 7966159..7967508
51% to 153A1
FORMERLY CYP153B3 CYP153A and CYP153B have merged
1 MDGRRRRPMP LPQAGEVRKT TGATTMNIQT PVKVDKAERM RRARGEAYAT PLAQFHPGAP
61 RLFQDDTLWP WFERLRKEEP VHYCTNAPIE PYWSVVKYND IMHVDTNHGI FSSDSTLGGI
121 SIRDVPEGYD YPSFIAMDQP RHSAQRKTVS PMFTPTHLDE LAKLIRQRSQ TVLDNLPRNE
181 TFNFVERVSI ELTTQMLATL FDFPWEERRK LTRWSDVSTA LPKSGIVASA EERRREMDEC
241 YAYMSKLWNE RVNSAPRNDL LSLMAHNDAT RFMDPDNLMG NIILLIVGGN DTTRNTMTGS
301 VLALNENPEQ YDKLRANPAL IDSMVPEVIR WQTPLAHMRR TALQDTEIGG KQIKKGDRVV
361 MWYVSGNRDE EAIDRPNEFI IDRPRPRTHL SFGFGIHRCV GMRLAELQLK IVWEEMLKRF
421 DRIEVVGEPK RIYSSFIKGY ESLPVRIPG
CYP153A5 Rhodopseudomonas palustris
NZ_AAAF01000001
complement(3283981..3285270) gene = Rpal2887
80% TO 153A4
FORMERLY CYP153B4 CYP153A and CYP153B have merged
MTWPGRTTMHGTIETGKAARLRAAREEAYATPLKDFHPGAPRHF
RDDTLWPWFERLRAEEPVHYCTNAPIEPYWSVTKYNDIMHVDTNHQIFSSDSTLGGIS
IRDAPVGYDWPSFIAMDEPRHSAQRKTVSPMFTPQHLDELAVLIRGRTQKVLDGLPRG
ETFNFVDRVSIELTTQMLATLFDFPFDERRKLTRWSDVATALPKSGVVDSEQQRRDEL
NECAAYFARMWNDRVNSEPRNDLLSMMAHHDATRTMDRDNLIGNILLLIVGGNDTTRN
TMSGSVLALNENPHEFEKLRANPKLIDTLVPEVIRWQTPLAHMRRTALQDAELGGKTI
RKGDRVVMWYVSGNRDDEVIERPEEFIIDRARARIHLSFGFGIHRCVGMRLAELQLRI
VWEEMLKRFERIEVVGEPKRVYSSFVKGYESLPVRVS
CYP153A6 Mycobacterium sp. HXN1500
No accession number
Jan van Beilen
Submitted to nomenclature committee 11/27/2003
66% to CYP153A2 62% to 153A4 55% to 153A1
CYP153A7 Sphingomonas sp. HXN200
No accession number
Jan van Beilen
Submitted to nomenclature committee 11/27/2003
66% to CYP153A2
clone name P450-A
CYP153A8 Sphingomonas sp. HXN200
No accession number
Jan van Beilen
Submitted to nomenclature committee 11/27/2003
62% to CYP153A2 59% to CYP153A4
clone name P450-E
CYP153A9 Bradyrhizobium japonicum USDA 110
GenPept BAC47118
NC_004463 complete genome 2007526..2008767
49% to 153A1 60% to 153A6 58% to 153A2
FORMERLY CYP153B1 CYP153A and CYP153B have merged
1 MNRRLEIHRA DDGYIIPLSE LDVSEGKRFQ DDSIWGCFER LRREDPVHYC QNSAHGPYWS
61 ITKYRDIVAV DTNHHAFSSQ QGVTIVEVPD KHWTPSFIKM GPPQHAEQRN TVSPIVGPES
121 LTRLETLIRS RVRMILDGLP RNEVFNWVTK VSIELTTQTL ATLFDFPFED RRLLTYWSDA
181 AVTTPKAGYA IDSWDKRSTI LSECLDYFTR LWNERINAEP RLDLISLMAH SPVTRHMEPT
241 EFLGNLILLI VGGNDTTRNS ITGGLLFMSQ YPSELRKLTD NPKLISSAVS EIIRYQTPIA
301 HMRRTAAIDS IVGGKPIRTG DKVVMWYISG NRDEEVIENA NSFVIDRKNV RQHLSFGFGI
361 HRCLGRHLAE LQLRVLWEEI LDGGLKIKVV GEPERIASNF VHGYSALPVR IEA
CYP153A10 Burkholderia fungorum
NZ_AAAJ02000161
complement(10797..12332) gene = Bcep0832
56% to 153A3 58% to 153A6 57% to 153A2
FORMERLY CYP153B5 CYP153A and CYP153B have merged
MRHVSCLRRSRLERSRGRARRPGGFHADLFTDPQGQLAALLPDR
GARGTRRTGPAPSRRPALTTLARHSNPVPDKALAPLTRNCHSAKVNCMNTLVVDSSHV
RLAPDALSQPVEDIDPSLPYRFQQQTHFAMFDRLRRESPVHYVKDSEYGPFWSVHRYN
DIIDVEIDHATFSSDVKYGGMLIKDLPENMRRTSFINADPPLHDHQRRVVSPIVAPGN
LNRLEHTIRREAADILDGLPRGETFDWVDNVSIELTGRVLCELMDFPRADRRLLTYWS
DIVNVDLEVGGEINTEEKRYVKLKECASYFGVLFKERMNSEPKDDLISMLAHSEYTKN
MPEQEFLGMIVLLMVGGNDTTRNSISGGLVALNQFPEQYAKLHNDPGLIPKLVPEILR
WVTPVTHMRRTATRDIEFRGKQIRQGDKVVVWYASGNRDSDVIKDPYQFIIDRANPRL
HLSFGFGIHRCLGNRLAELQLRVLWEEILKRQMLIEMMGEPVRKYANNITGVMALPVRIAA
CYP153A11 Sphingomonas sp. HXN200
No accession number
Jan van Beilen
Submitted to nomenclature committee 7/20/2004
80% to CYP153A8 62% to 153A2
clone name P450-C
CYP153A12 Alcanivorax borkumensis
No accession number
Jan van Beilen
Submitted to nomenclature committee 7/20/2004
66% to CYP153A1 94% to 153A13
clone name AP1-A
CYP153A13 Alcanivorax borkumensis Strain AP1
No accession number
Jan van Beilen
Submitted to nomenclature committee 7/20/2004
68% to CYP153A1 94% to 153A12
clone name AP1-B
CYP153A13a Alcanivorax borkumensis Strain SK2
GenEMBL AY505118.1
Jan van Beilen
Submitted to nomenclature committee 7/21/2004
Nearly identical to CYP153A13 from strain AP1
Two genes in this strain code for identical proteins
SK2 Abo_193 and Abo_2132
Protein seq for both is shown below
MSTSSSTSNDIQAKIINATSKVVPMHLQIKALKNLMKVKRKTIGTSRPQVHFVETDLPDVNDLAIEDIDTSNPFLYRQGK
ANAYFKRLRDEAPVHYQKNSAFGPFWSVTRYEDIVFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRRAVQ
GVVAPKNLKEMEGLIRKRTGDVLDSLPLDTPFNWVPVVSKELTGRMLASLLDFPYDEREKLVGWSDRLSGASSATGGEFT
NEDVFFDDAADMAWAFSKLWRDKEARQKAGEEPGFDLISMLQSNEDTKDLINRPLEFIGNLALLIVGGNDTTRNSMSGGV
LALNQFPEQFEKLKANPKLIPNMVSEIIRWQTPLAYMRRVAKQDVELNGQTIKKGDRVLMWYASGNQDERKFENPEQFII
DRKDTRNHVSFGYGVHRCMGNRLAELQLRILWEELLPRFENIEVIGEPERVQSNFVRGYSKMMVKLTAKK
CYP153A13b Alcanivorax borkumensis Strain SK2
No accession number
Jan van Beilen
Submitted to nomenclature committee 7/21/2004
Nearly identical to CYP153A13 from strain AP1
Two genes in this strain code for identical proteins
CYP153A14 Mycobacterium marinum
No accession number
Jan van Beilen
Submitted to nomenclature committee 7/20/2004
71% to CYP153A1
CYP153A15 Hyphomonas neptunium
gnl|TIGR_228405|contig:1062
Found in the genomic blast server at NCBI
http://www.ncbi.nlm.nih.gov/sutils/genom_table.cgi
859136 MAADTVSFVNHPALERPKVTEREPLHPHNLRFGANIPPAADIDLSTLDLIDGELWRQGKY 858957
858956 WDRFERLRNEDPLHYCPDSFPGPFWSVTRYEDVMAIDTDHKRFSSSWEYGGITLGEPISD 858777
858776 FEMPMFIAMDEPRHSEQRKTVQPAVAPDMLKVYEPLIRSRTQGLLDSLPVNEPFDWVDKV 858597
858596 SVELTTMMLATLFDYPFENRRDLTHWSDVATGMHNPDICPGGEEEWKATMMKCLMTFMGI 858417
858416 YQERQQQPQKPDLMSLLAHGEKTKNMTPMELLGNVILLIVGGNDTTRNSMTASVFALNKF 858237
858236 PKEYEKLKADPSIIPNMVSETIRWQTPLAYMRRTALEDVEMHGKTIKKGDQVAMWYVSAN 858057
858056 RDERFWDKPNDFIADRPEARRHISFGFGIHRCVGNRLAELQLRILWEEIMERFEHIEVLA 857877
857876 EPSLNQNAFVKGYNWMPVVLHPK 857808
CYP153A16 Mycobacterium marinum
No accession number
Tim Stinear
MM3154
67% to 153A1
CYP153A17 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
59% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
57% to CYP153A29 Parvibaculum lavamentivorans DS-1 CP000774
REGION: 1935500..1936753 protein ABS63400
Ectocarpus sctg_1 1458016-1459287
CYP153A18 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
57% to CYP153A2 Caulobacter crescentus at C-term
70% to seawater bacterial sequence CYP153A25 JCVI_PEP_1096681995831
Ectocarpus sctg_1 2416172-2417446
CYP153A19 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
59% to CYP153A8 Sphingomonas sp. HXN200
Ectocarpus sctg_1 2455477-2454218
CYP153A20 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
58% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
63% to Parvibaculum lavamentivorans DS-1
CP000774.1 REGION: 2309535..2310806
Ectocarpus sctg_1 2456749-2455490
CYP153A21 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
Ectocarpus sctg_1 2728336-2729601
CYP153A22 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
71% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
Ectocarpus sctg_1 2729680-2730936
CYP153A23 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
Ectocarpus sctg_1 2731016-2732278
CYP153A24 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
Ectocarpus sctg_1 2732360-2733622
CYP153A25 seawater sequencing J. Craig Venter Institute
JCVI_PEP_1096681995831
70% to CYP153A18
MSIHPEIDNSSGPLRELDVSLPEHYENDTWRPMFARLRKEAPVHYLSDSVNGPFWSVTSHALIKEVDANNSIFSSEKGGI
SIVDLKPVEGQVQGKNFIAMDEPEHSIQRSAVAPSVAPKNLVELEPLIRERAVDILENLPVGETFNWVQEVSIELTARML
TTILDFPYDQRHKLVQWSDLATDVPQVTGKEGTDMQARYDELMNCAAAFYQLWVSKSGQPPSFDLISMLQNNPDTARMNE
DMELFLGNMLLLIVGGNDTTRNSISGGVMALNQYPDEYQKLRDNPALIPNMVSEIIRWQTPVIHMRRTALEDYELGGQHI
KKGEKVIMWYLSGNRDESVFEDPDRLIIDRPNARSHVAFGFGVHRCMGNRMAELQLRVLWEEIMERFHTIEVVGDITRLP
NNFIRGIKEVPVRVHAH*
CYP153A26 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS61648.1 (protein)
CDS 27133..28401 locus_tag="Plav_0025"
73% to CYP153A2 Caulobacter crescentus
MSDAAVKYEADEARDEAYSIPLAEINVADPSLFRDYKMWPYFERLRAEAPVHYSQGNEDTGPYWSVTRYN
DIMSVDTNHQVFSSEGGITLRDQDEDFKLPMFIAMDPPKHDDQRKVVSPIVAPGNLAKLEGTIRERAGKI
LDELPTGEPVDWVDRVSIELTTQMLATLFDFPFEERRKLTRWSDVATATEESGIIESEEQRRAELLECAE
YFMGLWNERVNAREPGNDLISMLAHGESTRNMDKMEYLGNLILLIVGGNDTTRNSISGGLYALNKFPDQY
KKLLANPGIIPNMVPEIIRWQTPLAYMRRTALQDAEVGGQTIRKGEKVAMWYVSGNRDESVIQNPNELVI
DRERPRQHLSFGFGIHRCVGNRLAEMQLRIIWEEILKRWDQPIRVLSEPQRVHSSFVKGYEKMMVELPKR
KH
CYP153A27 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS63384.1 (protein)
CDS complement(1917064..1918329) locus_tag="Plav_1765"
68% to CYP153A2 Caulobacter crescentus
MSETLVAARDKSIADAYAIPLEKIDVSNPELFRANAIWPYFERLRREDPVHYCKESEYGSFWSVTKYKDI
MHVDTNHGIYSSEATLGGVALRNQEEGFFLPMFIMMDPPKHDAQRKVVSPIVAPGNLAKLEGTIRERAGN
ILDSLPVNETFDWVDRVSIELTTQMLATLFDFPWEERRKLTRWSDVAAAGTAFGDEETEKARRNELRDCA
AYFTELWNQRVNATEPGNDLITMLAQGEATKNMGPMEYLGNVLLLIVGGNDTTRNSITGGLLALNENPVQ
YKKLRDNPSLVESMVPEIIRWQTPLSHMRRTALQDTELGGKQIKKGDKVVMWYVSGNRDEEAIENANSFI
IDRKHPRQHLSFGFGIHRCVGNRLAEMQLRVVWEEILKRWPDKPIEVVGEPTRVFSNLIKGYSSMPVRIPG
CYP153A28P Parvibaculum lavamentivorans DS-1
CP000774 (genome)
CDS 1927820..1929084 locus_tag="Plav_1775"
67% to CYP153A2 Caulobacter crescentus
1927820 MSSMNVAERVQSLDDPYAIPLDKLNVSDPELFRSNRMWPYFERLRREDPVHYCAESAYGPFWSVTK 1928017
1928018 YKDIMHVETNHGVYSSDVEQ 1928077 (frameshift)
1928077 GGITIRDNNAGLKLP
1928122 MFIAMDPPKHDAQRKVVSPIVAPANLAKLEGTIRERAGKILDSLPVNETFNWVDRVSIEL 1928301
1928302 TTQMLATLFDFPWEERRKLTRWSDVATSEEAFKTPEGEAAREAELLECAAYFTELWNQRV 1928481
1928482 NATEPGGDLITMLAQGESTKNMSPAEYLGNVILLIVGGNDTTRNSLTGGLLALHE 1928646
1928647 NPDQYRKLRENPALVETMIPEIIRWQTPLTHMRRTALQDTELAGKRIKKGDRVVMWYVSG 1928826
1928827 NRDEEAIDEPNRFIIDRARPRQHLSFGFGIHRCVGNRLAEMQLRIVWEEILKRWPDKPIE 1929006
1929007 VVDEPKRVFSNFIKGYEALPVRIPG* 1929084
CYP153A29 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS63400.1 (protein)
CDS 1935500..1936753 locus_tag="Plav_1782"
73% to 153A8
temporarily named CYP153A26 but revised to match
genome order of P450 genes
1 MTTDTLVGDT ASTVPLSQMD VSDPKLFQSD MIGSYFARLR REDPVHYCPE SAYGPYWSVT
61 KFNDIMQVEV NHQTFSSEAK LGGIALQDMQ SGEAALELEM FIAMDPPKHD AQRKAVSPAV
121 APSNLVLLEP IIRERAGIIL DSLPIGEEID WVDRVSIELT TMTLATLFDF PWEERRKLTR
181 WSDVATSTPE TGVVSSFEQR REELLECAHY FKGLWDQRVN EPPKPDLISM MVHSPATRDM
241 PYLEFLGNLI LLIVGGNDTT RNSISGGVLA LNQNPAEYRK LMADPDLIPK MIPEIIRWQT
301 PLTHMRRTAL MDAEIGGKKI RKGDKVVMWY LSGNRDDEVI DRPNEFIINR PNSRHHLSFG
361 FGVHRCMGNR VAELQLRIIW EEILKRFSKV EVVGAPERTL SNFIRGFTHL PVKLYVH
CYP153A30 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS63566.1 (protein)
CDS 2129237..2130550 locus_tag="Plav_1951"
58% to CYP153A29 Parvibaculum lavamentivorans DS-1
54% to CYP153A2 Caulobacter crescentus
MSEQVSVGRDYTRSNADLAAKWKIDVNRDPWSIPLEELDPAHDELFAANTVLPYFERLRKEDPVHLNETG
PYGRYWSVTKYEDIMHVDTNHKIFSSDIRNGGIRLGGQRIEGEPDPLTYLPMFIMEDPPKHDEQRKAVQP
MFTPQNLADLEPLIRERAGLILDALPRGETFNWVRQVSVELTGRTLATLFNVPQEDRHKLIHWSDTVERL
GDPEYFETPEEGFKELWNCWEYFDGVWKDRLANPGSDLISLLAHSPSTKNMPPNEYLGNMLLLIVGGNDT
TRNSITGGVLALNQYPDEYAKLIANPDIIPNMVSEIIRWQSPVAHMCRTATEDTELGGKKIRKWDKVAMW
YVSGNRDDSKIDRANEFLIDREGARHHLSFGFGIHRCIGNRVGEMQLRILWEEIMKRFKKVEVVGDPKYL
RSNFIRGITELPVIVRE
CYP153A31 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS63742.1 (protein)
CDS complement(2309535..2310806) locus_tag="Plav_2128"
64% to CYP153A2 Caulobacter crescentus
77% to CYP153A7 Sphingomonas sp. HXN200
MTATASAAAPAGIDDPYALSLDQIDVSKPELFERNAEGAYFARLRREDPVHFCADSAYGPYWSITKYKDI
MAVDTNHQVFSSEAGLGGIIIEDGIQKSSGEGSIDLPNFIAMDPPKHDGQRKAVSPIVAPANLANLEGTI
RERVGRVLDGLPVGEEFDWVPAVSIELTTQMLATLFDFPFEERSKLTRWSDVATAEPGSGIVDSWEQRTS
EIMECAECFQGLWNERMEKPGMDLVSMMAHSPATHDMTPQNYLGNVLLLIVGGNDTTRNSMTGGVLALHQ
NPAEFAKLKANHGLIDSMVSETIRWQTPLAHMRRTALADAEVGGKTIRKGDKVVMWYVSGNRDKDVIIQP
DDFIIDRERPRQHLSFGFGVHRCVGNRLAEMQLKILWEEILKRFSRIEVTSEPVRTRSNFVRGYASMPVR
LHA
CYP153A32 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
82% to CYP153A16 Mycobacterium marinum
CYP153B1X Bradyrhizobium japonicum USDA 110
Renamed CYP153A9
CYP153B2X Bradyrhizobium japonicum USDA 110
Renamed CYP153A3
CYP153B3X Bradyrhizobium japonicum USDA 110
Renamed CYP153A4
CYP153B4X Bradyrhizobium japonicum USDA 110
Renamed CYP153A5
CYP153B5X Bradyrhizobium japonicum USDA 110
Renamed CYP153A10
CYP153C1 Novosphingobium aromaticivorans
GenEMBL NZ_AAAV01000116
complement(18298..19530) gene = Saro1194
45% to 153A5
MAATLAPDRAINPHDVSLNALYTEDRWREPFRWLRENMPVSYRA
ESPFGAYWSVVTHDLIQQVELDPGTYSSSWQRGNITIADSVNETEFPNFIAQDPPIHT
AQRKVIAPAFGPSQMVKLERLVRERTTQLLDGLPMGEEFDWVERVSIPLTLGMLLILF
DMPFDEWRDIKRWSDWASGVSEDSLNDAYRAEFVQQMGQMLMRFDRELEARRALPPSD
DLLSRMVHSDAMGHLTPPERIANIALLIVGGNDTTRNSMSGLIEALHRYPAELDKLRA
DPALSANAAQEIIRWQSPVTHMRRTLTRDAELGGQRLAEGDKIVMWYISGNRDENVFP
DAERFDVTRENARRHIGFGHGIHRCVGARLAEVQIAAVIEEIATRRLRITPQGAPTRL
ASPFLHGFTAMPVVMSRD
CYP153D1 Novosphingobium aromaticivorans
NZ_AAAV01000178
4242..5579 gene = Saro3794
47% to 153C1
MATQLAPEVPQFTYHSSPTATEAFAAWLKDNPQAIPAHSHPWDV
SRSDIYVEDRWQPIFAEMRAKAPVNRVPDSPYGAYWNVASHKAIMHVESLPELFSSSW
QYGGITIGDPPEDVDPQKLAERQLPMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEI
RRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWAGDVEL
TLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGN
LVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLIPNAVQECIRYVTPLAHMR
RTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNARRHLSFGHGIH
RCVGARLAELQLRILLEEMHERRMRVRVAGEVERVRANFVHGFRKLEVELEKR
CYP153D2 Sphingomonas sp. HXN200
No accession number
Jan van Beilen
Submitted to nomenclature committee 11/27/2003
55% to 153D1
clone name P450-D
CYP153D3 Sphingomonas sp. HXN200
No accession number
Jan van Beilen
Submitted to nomenclature committee 7/20/2004
59% to CYP153D1 68% to 153D2
clone name P450-B
CYP153E1 Erwinia chrysanthemi strain 3937
gnl|TIGR_198628|NC_003916
Jan van Beilen
Submitted to nomenclature committee 7/21/2004
Found in the genomic blast server at NCBI
http://www.ncbi.nlm.nih.gov/sutils/genom_table.cgi
4874678 MKMTKQLQDVFEDIDAVPLEKINPASRDRFINAAELPMFERLRREDPVHFTPESEFGPYW 4874499
4874498 SLTLWEDIRAVGNNYRDFTSTQNIDLKSIEEKIKLEAALQALGHERRKNVGFITMDPPEH 4874319
4874318 TKHRKAVTPAVGPSSLAQMEPIMRERAGIILDSLPIGEPFDWVDLVSKELTATVLATLLD 4874139
4874138 FPFEERRKLTFWSDLLMFEPGHGLVKSWEQKAEETVKCYQVFEALWEKRRNGPPSYDLIS 4873959
4873958 MLAHHPDTRDMTLEQFRGTIVLLIIGGNDTTRNTISSSLYLLDKYPEEFAKLKANPKLVM 4873779
4873778 PMISETLRFHPPVNFMSRVATRDVEIRGKNIKEGDRVVMWYTSGNRDASAIEDPDTFSID 4873599
4873598 RERARRHLSFGVGVHACIGSRVAEMQLTVIWEEILKRFSRIEVLEEPERSYSNFLHGFEN 4873419
4873418 LKVII 4873404
CYP154A1 Streptomyces coelicolor cosmid E6
GenEMBL AL353832 CDS 17561..18787
51% to AF145049 42% to AL158061 complement(14764..15987)
38% to 107A1, 107B1 39% to AF087022
cloned and expressed by David Lamb and Steve Kelly
CYP154A2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV109 70% to 154A1 from Streptomyces coelicolor
CYP154A3 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
75% to 154A1
clone name SP0673
CYP154A4 Streptomyces scabies
SCAB20211
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
57% to CYP154K1 Streptomyces rochei
58% to 154A1 Streptomyces coelicolor, note 154K1 is 52% to 154A1
CYP154A5 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1147
58% to CYP154A4 Streptomyces scabies SCAB20211
missing about 34 aa at N-term
CYP154A6 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE7009 67% to CYP154A1
CYP154A7 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6527 65% to CYP154A4
CYP154A8 Nocardia farcinica
YP118504
62% to CYP154A4 Streptomyces scabies
CYP154B1 Streptomyces fradiae tylosin-biosynt.
GenEMBL AF145049 CDS 3108..4409
51% to AL353832 CDS 17561..18787 44% to AL158061
complement(14764..15987)
39% to 107C1
CYP154B2 Streptomyces avermitilis
GenEMBL AP005036
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV3704 64% to 154B1 from Streptomyces fradiae
A tylosin-biosynthesis gene in fradiae
CYP154C1 Streptomyces coelicolor cosmid 6D11
GenEMBL AL158061 CDS complement(14764..15987)
44% to AF145049 42% to AL353832 CDS 17561..18787 39% to 107C1
cloned and expressed by David Lamb and Steve Kelly
CYP154C2 Streptomyces avermitilis
GenEMBL AP005036
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV3882 87% to 154C1 from Streptomyces coelicolor
CYP154C3 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1085
58% to CYP154C1
CYP154C4 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR3108
74% to CYP154C2
CYP154C5 Nocardia farcinica
AP006618.1 5611314-5612546 (+) strand
67% to CYP154C3 Streptomyces griseus
CYP154D1 Streptomyces avermitilis
GenEMBL AP005026
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV1308 47% to 154A1 from Streptomyces coelicolor,
46% to 154B1, 45% to 154C1
CYP154D2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_870
70% to CYP154D1 Streptomyces avermitilis
CYP154D3 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE5553 59% to CYP154D1
CYP154D4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2869 68% to CYP154D1
CYP154E1 Thermobifida fusca
GenEMBL NZ_AAAQ01000039b
99628..100836 gene = Tfus2243
49% to NZ_AAAQ01000042a 154F1
47% to NZ_AAAQ01000029a 154G1
46% to 154D1
MGQSRRPHTVYLDPAKGVDIPAQRRELLDKGPVVRVAFPGNLEV
WALTHDAPLRNALADESVFVRGWRNWRALMAGEVDPTHPVANMLRVESMLARSGADHK
RMRGLVQAAFTRRRVEALRPRIEEITNELLDRMAESDGVVDLKAAYSFPLPIRVISEL
LGLNEEDHLTLQTLVTRTLSGTDPEANADAFTFVASLIEAKRKNLDDGLISAMIEARA
EDGDRLSETELIHNTLLLIIGGFETTMGMISNSVQLLLTHPDQLHLLRTGQASWENAI
EECLRFESAVVMLPFLYTTRDVEIDGITIPAGDAVLIGFGPANRDPQAYDDPDRFDIT
RPRPRHLAFGHGAHLCLGAALARLELLIALPALFERFPDITLVGEAPPTPTVFMNHPL
SRPVLLRPKP
CYP154F1 Thermobifida fusca
GenEMBL NZ_AAAQ01000042a
complement(347138..348745) gene = Tfus3014
49% to NZ_AAAQ01000039b 154E1
44% to 154C1 and 154C2
N-terminal extension may be incorrect
MAVSADHAAAGALPGARHPAGRRVRAGRRLLDHRLRSGTRRPGG
CPVHRPAQPVRDPRPPGVGDRAPRVPGAADLPADRGRRGECAAGPVAGRASRGSPRVA
GAAPFPVRPRTQGASCHLHPRRHHPTNGGT
MAAVPEPIVLVPGKSREQALQLREAGPL
ARVVVEGLEVWALTHDRELREALIDPRFRRNWRTWRALNEGEVATDHPVAAMVYLDNM
LTVDGEAHRRMRSPVAQAFTPRRVELLRPRVTEIVNALLDQLAERDGTVDFKTEFAYP
LSMRVFSALFGIPERDHGRMQQMVNTAFSPSSPEEVRAMREELDAFLDELIEDKRRSP
GEDLTSALVTATDEEHKLSDAELRDTLWLLVTAGFETTSSALANAVQTLLTHPDQLAH
LRSGSIAWEDAIEEVLRQSSSVATLPFLFAAEDVQIGDRTIRAGEPVLLAYLAANLDV
ERYGEDAAEFDATQSRPRHLAFGHGPHTCLGAALARLEMEVALTTLFTEFPEVSLAEG
EAPRLESVFIHAPAALPIRLGPRRTAA
CYP154G1 Thermobifida fusca
GenEMBL NZ_AAAQ01000029a
complement(12913..14079) gene = Tfus0891
47% to NZ_AAAQ01000039b 154E1
41% to 154C1
MLDTERGLTEADIHALAEHGPVVRLSVMGLDVWAVTGYEELRTL
MADPEVKRGVEHWTAVAQGKVPAEHPLVKLVSMGSMLSKNPPEHTRLRRLVQHAFTTR
RVEGLRPVVQELTRACLDRIDASQPFDINAALSHPVPVGVIGRLLGIPETDQPALDSL
VTRLLSGTDATVHEELYAYVAAMVAARREQPDDGLISALLHVHDDDGSTLSEEDLMWT
VVLLVDAGFETTVGQISNSVRLLLEHPDQLALVTSGEVPWERAVEECLRHTASVVMLP
FCFPTREKELGGYTIGAGEPVMMVYGAANRDSRVHAAPKVFDVTRSDSRHITFGHGPH
HCLGAPLARLELNVVLPELFARFPKLALAERDIPRVKSLFVNRPSELWVTAGMG
CYP154H1 Thermobifida fusca
GenEMBL NZ_AAAQ01000035b
93951..95183 gene = Tfus1569
51% to 154C2
MMASPTDNPIVLDPYVSDLEGERERLYEAGPIAWVELPGGVRTW
SVTHHQAARELLTDSRLSKNMAHWGAYNRGEISPTWPLLSVIPPTPTNLLGTDGAEHK
RLRTLTAQAFTPRRVEKLRPRIREITEELLDALEERANEPQDLKSEFSFKLPMRVIGE
LYGVEEAAHGQLRSLYDKFFSSVTPPEEFLATREALVQFYTELMERKKANPSDDLTTA
LLQANENGDRMTDEEVLGTLQIVVAAGHETTVNLLTNTVRALLRFPDQLELLRTGKAT
WEAAIEESLRWDPPTTNFIFRFATEDIEYGGVTIAKGDSVMISYGAIGRDRGQHGDNP
EVFDVTRKTSSRHISFGYGPHVCPGAPLARLEAQVALPMLFERYPDMKLAVDDSELVP
NPSVIVNSLKEFPVILRP
CYP154J1 Streptomyces carzinostaticus subsp. neocarzinostaticus
GenEMBL AY117439
complement(35390..36622)
47% to 154B1
MCPYRLDPEGADTHGETARLREQGPIARVELQDGVLAWSVHDYA
VAKQIMADERFSKNPRKNWPAYINGEISNGWPLITWVAMDTMATQDGADHARLRKLLL
KAFTERRVESMRPHIEKTVKELLDNMAAKADDEIVDIKEMFHAELPTRLMCDLFGVPE
ERRAEVLAGGHKNIDTRISSEAAEANLGQWQEAISDLVEYKRHHPGDDLTSALIEARD
EGSRLSDSELIGTLHLLLGAGSETLVNALAHSSLALLVDADLRKKVTSGEIPWVNVWE
ETLRVESPVAHLPFRYATEDFEIGGVKISKGDPLLVDFAGIGRDPAVHSDAPDEFDAL
RPDKTHLSFGHGVHYCLGARLAKHAWMIGIPALFERFPDMELAVRRDELKGQGSFVVN
GHASLPVHLKGRAAALAR
CYP154K1 Streptomyces rochei plasmid pSLA2-L
NC_004808 complement(144081..145325)
53% to 154B2
note = ORF84
MLRQEAPYVIDSAGRDLPGEAARLRERGPVVRVVLPGGVSAWAV
TDLDLIKQLLTDSRASKDAYRHWPAWAGGEVDESWQMSMWVSVRNMLTAYGEEHARLR
RLVAGAFTARRTADLRPRVERITARLLDGLAAVPPGAAVDVRNEFARPLSVLVMGETL
GLPEDLHADLQRMVDVLFKTTAEPEEARANQYELYALLTELVAARRSAPGTDLTSELI
AARDEDGGEGLSEKELVDTLLLLIGAGTETTVNLIDQAVHGLITHPAQLALVLGGEAT
WDSVIDETLRHQPVVANVPFRFAVEDIEVGGVTIPKGDPILLSLAAAARCPHRHGADA
DQFDVARPSRRDHVPFGYGVHHCVGRPLARLEVSIALESLFARYPRMAAAVPEAELAV
RESFISSGHVALPVVLVPGAAA
CYP154L1 Streptomyces scabies
SCAB32131
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
49% to 154A1, 47% to 154B1, 47% to 154K1
CYP154M1 Salinispora tropica (marine actinomycete)
Strop_2724 complement(3069331..3070560)
51% to CYP154J1 Streptomyces carzinostaticus
MRRRCPVVIDPAGTDIHAEGARIRANGSVSQVELPGGVLAWSVTGQQVARKVLSDQRFSK
DPRKHWTDYLEGRIGQDFPLIGWVLMDNLTTAYGSDHSRLRKPCANAFTPRRVEALRPAV
ERAAVELLGELATVSPTESVDLKARYAHPLPSRVICDLFGVPEEDREEMLRGGEVNVDTR
VSAEEAAANVERWHQQMLDFIEEKRRNPGPDLTSDLIAAQQAEGSRLTDSEMVGTLHIML
ATGTEPVKNLIGNAVFALLTHPEQLDLVRSGRAGWDDVIQETLRMQAPVAHLPFRFAVED
VDIDGVTIRRGDPLLVNFAAIGRDPDVHGDTAAEFDITRADKEHLSFGHGVYRCIGQPLA
LREAEIALRMLFQRFPNLVLAVPPEEVTPQPTFIMNGLDTLPVLLKGRA
CYP154M2 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR622
69% to CYP154M1
CYP154M3 Streptomyces ghanaensis ATCC 14672
GenPept EFE72442.1
CYP154N1 Frankia alni ACN14a
YP_711761.1
CAJ60170.1
52% to CYP154L1 Streptomyces scabies
MVHVQPLSVAAAGPSLVAEAAALRARGPVAEVTLPGGIPAYAVNEHALLRALLLDPRVSKDPRRHWAQWD
EACRRPEWGWVLQWVGVVNMLSTYGVDHARLRRLVAPSFSARRTELLRPAVVAVTERLLDDLAAGSARAA
GSAGSVGSVGSVGSAGSVGSAGSVGSARSVGSAGSAGSVVDLVGTFAQPLPLAVISGLFGIPDRMRPDFA
HVVEQIMNTTVSSEQAAANLGRTRSVLATLVERKVREPGDDLTSELIGVRDAVTGDRLAHRELLDTLLLL
ISAGHETTRHLLGNAVHALLTHDRQLRRLRAGEITWDQVVEETLRWAPSIANIPLRFAVTDIDTGAVTIP
AGAAIVAGILAAGHDPGHHGPGASRFEPGRDAADHLAFGVGVHRCLGAPLARLEAGYALPALFARFPGLA
LATPADDLPQAPSFIVHGWQALPVRLAPPAPLVTASAR
CYP154P1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1935
43% to CYP154D1 Streptomyces avermitilis
41% to CYP154H1 Thermobifida fusca
CYP154P2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY842 70% to CYP154P1
CYP154Q1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6952
CYP154R1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY5125
CYP154S1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY1366
CYP155A1 Streptomyces coelicolor cosmid 6D11
GenEMBL AL158061 CDS complement(40542..>41807)
32% to AF127374 new family
cloned and expressed by David Lamb and Steve Kelly
CYP155A2 Saccharopolyspora erythraea NRRL23338
SACE_3189, se: 3523366,3524559 (-) STRAND,
63% to CYP155A1, 47% to 155B1
MPTDSTDARKIDRGETEGGCPVHRRPDGVWEVRGYASARAVLRSTDTVQAGLGVETVEKM
PSRIRRPVLYRDGTEHREHRRQTARYFTPRRVDEHYRDIMERVTDEQLAKLRADGRAQLS
ELSFHLAIDVASSVIGLTESKPGIQARLERFFPEEFGEPGFTSINGIYWIFRQLRNWLGI
YLGDVRPAVRARKRRRQDDLISHLLDEGCSSAEILGECITFAAAGMVTTREFVNLAAWHL
FTDEALRERYRSAEEAERLEVLHELLRLEPVVGHLRRRTNAELRVPDGDSEVTVPAGEVV
DIVVSATNLDERVMGEQPASLCPGRELSDGAYAHGMSFGDGAHKCPGAHIAILETDTFLR
KLFALPGVTMETPPRVTFNDAIGGYELRDLVVSVSAN
CYP155A3 Frankia sp. CcI3
YP_481069.1
ABD11340.1
not like Frankia alni P450s same as |ABD11340
58% to CYP155A2 Saccharopolyspora erythraea
MADPVVTDVGTSARKIDREDPNGGCPVVQGADGVWRISGYAAGQAVLRSLETKQAGLGIDASKAIPKRIR
RPVLHSDGPEHRERRRLTARFFTLRRVDEHYRELMHRVADEQIDRLRRERSVDLSELSFALAVEVAAAVI
GLTNSRPGMAARLERFAQGDLGPPNVTSIRGIRQFIRQNRHALAFYLADVRPAVRARRRRRTDDLISHMI
DQGCTNAEIFAECVTFAPAGMITTREFINVAAWHLFTDDTLRARYHDADQTERIAILHEFLRLEPVISTL
KRRTTADIQLPGPHGPLTIPAGAQIDIAVSSTNIDTQAIGADPYTVRPARPIGDGVSPAGLSFGDGPHKC
PGAHVAIHETDIFLHKLFMLDGLHMASPPQVTLRDEIAAYELRGLVVTLD
CYP155A4 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1967
68% to CYP155A2 Saccharopolyspora erythraea NRRL23338
CYP155B1 Deinococcus radiodurans
NC_001264 192795..193784
frameshifted C-term, frameshift not a seq error
43% to 155A1
MPSFLSFRSSAMTAHDAQPEPARCPFTGQAAPTETITRRHVPPQ
GDLAQPVETYARARDLLKSEQAQQAGFLADMVSRVPGSQHPPVLYLEGEEHTEMRRAT
AKYFTPTQVNTYQPDIARLADELIGKLARRGEAKLDDLSLELAVRVAAGVVGLTNSRL
PGMDRRIERFIPSGVDAEPGVKLEGASPLENARQAANMALFYALDVKPAIEARRKAPQ
DDLISYLLSRGYNDQDILTECVTYGTAGMITTREFISVAAWHLLKNPELRAAYVHGTE
KERHAVLHEILRLEPVVGTLYRRA
GTGDDCGRRSHPAGSVFALDIGQANLDPAVMGEGAEQLCPMRELPRGVQAQGLSFG
DGHHRCPGAFLAIKETDVFLRRLLIWNDLHVVSEPRVTYNEVIKGYELRGFRVRLGGARA*
CYP155B2P Deinococcus radiodurans
GenEMBL NC_000959 73..384
plasmid CP1
44% to 155B1
C-term only runs off end might be a full gene
SGSTDAEILPYVVEAEPSSPVVHLDISQ
ANRDESVFTQAQQFCPHRKNVRQHLSFGKGEHACLGQSLVYTICRVMAHALELLSAPAGQ
RTDQVSQ*
CYP155C1 Brevibacterium linens strain ATCC 9175
GenEMBL AF139916
Krubasik P, Sandmann G.
A carotenogenic gene cluster from Brevibacterium linens with novel
lycopene cyclase genes involved in the synthesis of aromatic
carotenoids.
Mol Gen Genet. 2000 Apr;263(3):423-32.
87% identical to CYP155C2
complement(9188..10417)
MNSVSMRKAVGTHDETEPRVGHDGTMWRIRSYEAATTVLRARHQ
TTQAGFTAEKIPRGYFRQHPILISDGDDHDVQRREVARYFAPAVVSAKYGDFINKRAQ
ALVDSALANGRLRLDEAALNYSVEVTAEIVGLTDSPIDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWIQAAVNGLVPIGRFYISDVRPAIRARRDRRRDDVLSHLLSAGYSTADIL
VECVTYGTAGMVTTREFITMACWHLLTNDELGRRYTEASQPTRLEILEEIIRLDPVVG
HLYRRAQADIEVSDNGCPYTIPEGDLIDVCVRQTNTDPQAMGAAPETVIPGRDLRRGS
AATGLSFSDGAHTCPGQPLALYETDALLHKVLATRPRILREPTISWDNVIEGYRLRGL
DLSLMTRSRPVTTRMTT
CYP155C2 Brevibacterium linens strain ATCC 9174 (JGI genome project)
Version 09sep02 - Scaffold2 Gene 3393
This sequence is 40% identical to CYP155B1 from
Deinococcus radiodurans NC_001264 192795..193784.
It is about 37% to CYP155A1 AL158061.1 Streptomyces coelicolor.
MNSAGMRKAVGAHDETEPRVEHDGAMWRIRSYEAATTVLRARHRTTQAGFTAEKIPRGYFRKHPILISDGDEHDSQRKEV
ARYFAPAVVSAKYGEFINERAQALVDRAVANGGLRLDEAALNYSVEVTAEIVGLTESSTDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWAQAAVNGLLPIGRFYVHDVQPAIRSRRSRRRDDVLSHLLSAGYSTADILVECMTYGTAGMVTTREFITMAC
WHLLTDEELGRRYTESSQPTRLKILEEIIRLDPVVGHLYRRAQADIEVSDNGCPHTISAGDLIDVCVRQTNTDPHAMGTA
PETIIPGRDLGRGTAATGLSFSDGAHACPGQPLALYETDALVHKLLTIGPRILRKPEISWDNLIEGYRLRGMDLSLMERS
RPAATREPI
CYP155D1 Frankia sp. EAN1pec
YP_001507958.1
ABW13052.1
41% to CYP155A2 Saccharopolyspora erythraea
MTTTELPKCPMDPTRDDRKSAALAAQRVRADAGARVVGSFDFGRAILRSATMLQAGAGSEQVKVGGDEHG
PVFFLDGEEHRRRRTAIARFFTPKAISTRHRLVMERTSDELLARLRAKGGGQLDELSYQLAVAVAAEIVG
LTDSNQVAMARRIQATLLGTRLRGMHPVIRVGAQALTAVHAMRFFLRDVRPAIRSRRRERRDDVISHLID
EGYPDKAILIECMTYAVAGMVTTREFIVMVAWHLFDNDELRARFTAGGEADQTAIIEEILRLEPVAAMLH
RRATQDSDLGVGSVKEGELLAVSIRAANVDPETVGECPHALDPDRARRLKAVGSYMSFGDGSHRCPGAQV
AINETRVFLDRLMRLPDLRLARTPDMTWCDGLMSYELRGATVTCSRDLTPAAHEVGQDAGPDGEQT
CYP156A1 Streptomyces coelicolor cosmid E6 gene
AL353832 16317..17549
34% to AL158061 complement(15984..17225)
cloned and expressed by David Lamb and Steve Kelly
CYP156A2 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE7011 67% to CYP156A1
CYP156B1 Streptomyces coelicolor cosmid IF3 gene
AL590982.1 10933-12276
41% to 156A1
cloned and expressed by David Lamb and Steve Kelly
CYP156B2 Streptomyces scabies
SCAB79211
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
65% to 156B1
CYP156B3 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE4276 63% to CYP156B2
CYP156B4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY3624 59% to CYP156B2
CYP156B5 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR3494
59% to CYP156B4
CYP156C1 Streptomyces scabies
SCAB20221
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
54% TO 156B2, 51% to 156A1, 50% to 156B1
CYP156C2P Saccharopolyspora erythraea NRRL23338
SACE_4886, se: 5459819,5460361 (-) STRAND
56% to 156C1, 46% TO 156A1 AA 138-308
LINEFGSAGEADLLTQYAGPLTLRVLTWLFGCPTDLGQRLLADMAHIADAADAGAAGEAG
ADLDECLRRLVHLKRGHPGRGVTSRLMAHSAQLSDDEVVHQLVILMGVSGEAQQNLISNA
LRLLLSDERFAGDLSGGSLPVEDALDEVLWADPPIANHSTAYPTREVHLDGVHLPRVNRW
CYP156C3 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1148
57% to CYP156C1 Streptomyces scabies SCAB20221
CYP156C4 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1149
59% to CYP156C1 Streptomyces scabies SCAB20221
80% to CYP156C3, 58% to CYP156C5
CYP156C5 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_5524
58% to CYP156C1 Streptomyces scabies SCAB20221
60% without 16 aa insertion
CYP156C6 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6526 66% to CYP156C5
CYP156D1 Streptomyces scabies
SCAB32121
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
41% to 156B1, 38% to 156A1
CYP156E1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_8426
52% to CYP156C1 Streptomyces scabies SCAB20221
CYP156E2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY3639 64% to CYP156E1
CYP156F1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_8398
56% to CYP156B2 Streptomyces scabies SCAB79211
missing N-term 165 amino acids
CYP157A1 Streptomyces coelicolor cosmid 6D11
GenEMBL AL158061 CDS complement(15984..17225)
51% to AL132991 complement(7477..8739) 40% to AL132648
cloned and expressed by David Lamb and Steve Kelly
CYP157A2 Streptomyces avermitilis
GenEMBL AP005036
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV3881 86% to 157A1 from Streptomyces coelicolor
CYP157A3 Thermobifida fusca
GenEMBL NZ_AAAQ01000035a
92419..93954 gene = Tfus1568
55% to 157A1
MGPAVHRGARRSRPRRRPPTRRLLVLHRPAGGARHSLRRRPQQL
RVLLHPGPDPRGTRPGPLSPPPGMRRPGTRVRQTGAGHPGPTCDDDHRGGGRPMNAQR
GIPSSHQNAFRLYGPQFQNKPAELYRQMRTDYGPVAPVLLDGDIPAWLVIGYREVTHV
LNHPETFARSSRRWNAWDLVPENWPLYPMVTRTPNILYSEGEEHRRRATAISDALSGA
DQHEVRQYAVQAADRLIDGFCAASRADLRADYASRLPAIVLGRLYGLDQKHAEVLAEA
MTTMIDSGPDAVKAQQFLLQTMGTLVAERRKQPGPDVVSRLVHHPAKLRDEELIPDLV
VILGGGHQPTTEWLGNTLRLMLTDDRFAASLTGARSSVREALNEVLWEDTPTQIYLGR
YAAHDVELGGQLIRRGDLVLLGLAGANSDPQINPGPECRMSQGNQAYLSFSHGEHRCP
YPAPELAEIIVTAGIEVLLDRLPDVELAVPVDELRWRPSPWMRGLVALPVVFTPVPPI
GGQ
CYP157A4 Streptomyces scabies
SCAB51111
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
71% to 157A2 Streptomyces avermitilis
CYP157A5 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6784 61% to CYP157A1
CYP157A6 Streptomyces cyaneofuscatus IT17-157
AB426723.1
80% to CYP157A1
CYP157A7 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1086
59% to CYP157A1
CYP157A8 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1086
80% to CYP157A1
CYP157B1 Streptomyces coelicolor cosmid F55
GenEMBL AL132991 CDS complement(7477..8739)
51% to AL158061 (15984..17225) new family
cloned and expressed by David Lamb and Steve Kelly
CYP157B2 Streptomyces hygroscopicus subsp. yingchengensis
AY260760 complement(2270..4150)
P450 fusion protein
83% to 157B1 C-term part
gene = shy2
note= fusion to ATP/GTP binding protein at N-term
MGSATSELPSQRTPLTAAAETGLKIVVVGGFGVGKTTLVRSVSE
IRPLNTEELMTQAGQGIDETAGVERKTTTTVAFDFGRISLNDRMVLYLFGAPGQERFW
FLWDRLFAGTLGAVVLVDTRRMEDCWYAIDRLEHHGTPFVVAVNRFDGDEKRFSLDEV
RQALALGEHVPMIECDARVRASGKEVLIALVDHLYTRALAKESTACSDTTGFPSTDAP
PPGCPAHGSAVPLAGLEYQQTPSQLYRTLRREHGAVAPVLLDGGIPAWLVLGYPEVCY
VTAHDELFARDSRRWNQWEHIPPDWPLLPYVGYQPSVLFTEGAEHQRRAGVITQALEG
VDQFELARECQLIAARLISSFSGSGRAELMSMYAHALPARGVLWMCGMPAEDADTERL
VDDLRISLDAGEGDDPVAAYTRVGERIMRLVKEKRERPGPDVTSRMILHPAGLGDEEI
VQDLISVIAAAQQPTANWICNTLRLLLTDERFAVNVAGGRVSVGEALNEVLWLDTPTQ
NFIGRWAVRDTQLGGRHIREGDCLVLGLAAANTDPQIWPEPHAGSGNSAHLSFSNGEH
RCPYPAPLLADVMARTAVETLLEHLPDLVLAVEPEELTWRPSIWMRGLTSLPVEFTPA
MN
CYP157B3 Saccharopolyspora erythraea NRRL23338
SACE_1153, se: 1272726,1274018 (+) STRAND,
56% to CYP157B1
MTGASEVEWPAADAPSDCPVQEVPAAPQEHAVRMYGPILQRDPKELYREMRREHGPVAPI
LLEGDLPAWLVLGYREVHQVTTDSELFARNSRRWNHWDDVPEGHPLWPWLGIDHSVLVSE
GEEHRRRAGAISDALAAVDQFELWDHCARIADRLIDSFAGSGRADLIAEYTDRIPLLVVT
TMFGMTEEQTRNLIGDLSTTIDAAEGAGAAHNRVVDRMRALLAVKRERPGNDLPTRLLGH
PSTADDDECAIDLVILLTAAHQPTASWIGNTLRLLLTDERFALTLSGGRRSVGDALNEVL
WEDSPVSNLLGRWAARDTQLGGRAIRKGDLLLLGYNAANSDPQVWPDGTNAHMAGNHAHM
AFGHGEHGCPFPAPELAEVIAKSTIEVLLDRLPDLRLAVEPEALRWRQSTTIRGLVDLPV
EFSPTYAKRP
CYP157B4 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9885
56% to CYP157B2 Streptomyces hygroscopicus subsp. yingchengensis
CYP157B5 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9382
62% to CYP157B4
53% to CYP157D1 Frankia alni ACN14a
CYP157B6 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE2761 69% to CYP157B2
CYP157B7 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE5134 57% to CYP157B6
CYP157B8 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY4504 79% to CYP157B5
CYP157B9 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR4392
79% to CYP157B1
CYP157C1 Streptomyces coelicolor cosmid I41
AL132648 CDS complement(9396..10892)
40% to AL158061 (15984..17225) 39% to AL132991 complement(7477..8739)
cloned and expressed by David Lamb and Steve Kelly
CYP157C2 Streptomyces avermitilis
GenEMBL AP005047
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV6706 70% to 157C1 from Streptomyces coelicolor
CYP157C3 Streptomyces griseus
GenEMBL AB044803 3754..5328
61% to 157C2
gene = rarE
MTTPFHHEPGTVPPPQCPAHNLDIGPGGLRRLHGPEAENNPAGL
YDKLRAEHGTVAPILLHGDVPAWLVLGHSENLHVTRTPSQFSRDSRRWRALQDGSVAP
DHPLAPIFTWQPICVFADGPKHERQRGAVTDSMERIDTRGVRRHINRFSNRLVNDFCE
KGTADLVGQFAEHLPMMVVCAIFGMPEEYDERLVQAARDMTRGTETAVASNAHIVSVL
TRLVERRRAEPSPDLASWLVEHPATMTDTEVIEHLRLIMIAAYESTANLIANVLRMVL
IDPRFRARLSGGHMTVPEAVEQTLWDEPPFTAVFGRWAVGDTELGGQQIKAGDALLVG
IAPANTDPTVRPDLGADMGGNRAHLAFSGGPHECPGQDIGRAIADVGVDALLMRLPDL
ELGVGESELHWVGNIMSRHLVELPVKFAPGPQQKLDADPLTVMARLLAPPTPGRSPPR
PGRSPSPATRGPWRRAHAPGAAPTAEPDPAPAAPPAPEPAAAPEPAPVATIPQQRRPA
APARFWQAVTRWWSGY
CYP157C4 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
57% to 157C3
clone name SP0618
CYP157C5 Streptomyces scabies
SCAB73721
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
76% to 157C2
CYP157C6 Frankia sp. CcI3
YP_483409.1
ABD13680.1
39% to CYP157D1 CAJ59158 same as YP_483409
56% to CYP157C4 Streptomyces peucetius
MSTPIPEAGAESGAAIPPPGCPAHAAFAQDAVRTALYGPEAQHDPGAVYEKLRAEHGGIAPVELEGGVPA
WLVLGYRENMEVARTPSRFTRDARLWRDWNEGRIAADDPLLPLIGWRPDVVSYDGEEHARLRAAVNECLT
RFDRHGTRRHVQRYANQLIDGFVEDGRADLVTQFAVYLPMLVLSRLVGLSEGYGRKLVEAIVGMVSGGED
AYAHNQYIIGTLRSLTEERRRAPAHDLASWFVQHPSGLNDEEVLNHLRLVIVLGYEATANLVSNTLRMVL
TDPRFRASLAGGLMTLPDAVEQMLWDDPPLLVCPARFATHDMHFADKEIREGDMLLLGIAAGNADPEIRP
DLGAPMHGNRSHLAFSRGPHECSGQEIARAITDTGVDVLLNRLPDLHLTVPEEQLTWTASTWSRHLDALP
VKFAPQCRPVPQSAPAAPAFSAPVVEPSAAKDALAAVAEADAQARADTRRGFWASLGGMFRGRR
CYP157C7 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7811
60% to CYP157C4 Streptomyces peucetius
CYP157C8 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY1152 63% to CYP157C4
CYP157C9 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY8043 67% to CYP157C4
CYP157C10 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1059
94% to CYP157C3
CYP157D1 Frankia alni ACN14a
YP_710767.1
CAJ59158.1
55% to YP_001509751 EAN1pec
54% to CYP157A2 Streptomyces avermitilis
MTPPSHDRVDTWAPAPAAPELAAPAPGFPDHPGAVRLYGPRFQHNPAQMYREMRRVHGPVAPILLDGDIP
AWLVLGYRELHYVTSNPELYGRDPRRWNAWDRVPPDWPLLPVVGYQPYTMHLEGAEFERRSAIMNDVLGD
VDLFELRALCERTCDELIDGFAGRGEADLITEYAQSMPMLLIGRMIGIPEAGLPELLASMNAATDGSGPE
AVAGHSRFVAIINALLADRRARPRPDLPSAMLGHPGKLTDEEASWDLLLIVGIGQQPITDWIGNTLRLML
TDSRFAVTLSGGRRSVGQALNEVLWEDTPLQNMSGRWAVRSTQLAGQHIQAGDMLVLSCAAANGDPQVRP
DSFEGPGGNHAHMSFGHGEHRCPYPAQEIAETIVRGAVEVLLDRLPDAVLAVSPDALVWRPSPWMRGLSA
LPVHFSPS
CYP157D2 Frankia sp. EAN1pec
YP_001509751.1
ABW14845.1
52% to CYP157B1 Streptomyces coelicolor
MTTAREPARESLRGPAREPAREPARAARERPPGGRTPPCHLGEAQFQGGPARAYRDLRRKHGAVAPVLLD
GGLPAWLVLGYRELHYVLSHPEIFAHDPRHWAGWDDVPPDWAALPGVGHRPSVLRAEGAEHRRRYTAIQD
VLGAVDLFELRARAEEITDDVIDAFAGRGETDLIDSFAHRVPALVLASLCGPPEVDTAGLVHDLIVLIDD
GPDAAESHQRVLDRLRWLLADRREHPDDDIVSRLIAHPAGLADEEVVEDLAVVFGFGARAVAGWIGNSLR
LLLTDGSFALDLSGGRRSVMQALNQVLWEDTPMQVVAGRWATRNTQLGGQRIEAGDMIALGLGAGNADPQ
VRRGHAPDTQTGAGTSANSAHLSFGHGEHRCPYPAQEIAEVVTRTAVEALLDRLPNMWIAVPADALGWRR
TAWNRALTALPVRFSPV
CYP157E1 Frankia sp. EAN1pec
YP_001509752.1
ABW14846.1
48% to CYP157A3 Thermobifida fusca
MTHPNPRQLGTCASGMPRAFGAVRQLGALRQYGASCPAPTTRRGGPEDTPSGEPVPGPSSGPPSGPRGGP
VRGTAGAHPPARPDLDARWPAHATAVRLPADGPGDDRAAFYRRIRDEHGPVAPVLLEGDVPAWLVLGYRE
VVYVAGTPALFGRDCRIWNAWDLVPPAWPLQSMVGQRPSLRALDGPAHARRLGAIGDVLGMFEPHGLRAR
AASGADALIDAMASDGRAELMTQYASPLPAMVAAGMWGLPDTDLTALARDLTLLVSGGTGARDARRRAHA
MLTRVVRRRRAQPGDDAVSALLTHPAGLRDDEVVEDVMATLIAGQAPTADWIGNTLRLMLTDPRFATDLA
GGRLSAGDAMAEVLWADPPIQNLVARWARRDVRLGGRWIRAGDLLIFGLSAANSDPWARPQPSGRPSGNH
AHLAFGHGEHRCPFPAQMTAETIATTAIEVLLDRLPDLELAVEPRDLRWRPSVWARGVAALPVRFTPP
CYP157F1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_871
47% to CYP157C6 Frankia sp. CcI3
missing about 33 aa at N-term
CYP157F2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2868 81% to CYP157F1
CYP157G1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_4984
50% to CYP157B3 Saccharopolyspora erythraea NRRL23338
CYP157G2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY6022 65% to CYP157G1
CYP157H1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY5124 51% to CYP157A1
CYP158A1 Streptomyces coelicolor cosmid 8F11
AL353864 CDS complement(25687..26910)
40% to AF254925, 107E1, 107F1 34% to 107A1 probably a new family
cloned and expressed by David Lamb and Steve Kelly
CYP158A2 Streptomyces coelicolor 2StG58 [Full Sequence] Sanger cosmid
AL939108.1 CDS 76346-77560 61% to 158A1
Note this sequence shows greater than 40% identity to some CYP107
subfamilies
cloned and expressed by David Lamb and Steve Kelly
CYP158A3 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV7130 58% to 158A1 from Streptomyces coelicolor
CYP158B1 Saccharopolyspora erythraea
GenEMBL AY078067 4211..5416
gene = rppB
red pigment gene cluster
47% to 158A3
MTDRCPARMYDPADLPGMTFDPVFLELLRDEPVARIRMRYGEGE
AWLLTRYEDVKFVTSDPRFSRKIMGRPFPKMTKHHIPMDRAISFSDPPEHARVRRVVA
RDFSPGSIERLRPTGREIMHRYLDELVASGPPADLVRHVTSPFPMAVLGELMGIPESD
RQWLIDCSSQVLSMAPDQAAVDRINGIKAEVAEYFLALVESRRADPRDDVVSTVAAAR
ERGDLDDEEVGAMTVLLALNGWHAVRNNSTNMVYVLLTDPELRSRLKADLALVPTAVE
ELLRYIPHKRGIGQPRIATEDVDIRGVRISKGDVVYVSYIAANWDEEVYPEPDRVDLD
RPEVPHLAFGHGPHYCMGPMLARMESQVLLSSLLTRLPDLALAVPPEQVAWQPNALIR
GPVELPVTW
CYP158B1 Saccharopolyspora erythraea NRRL23338
SACE_1242, se: 1364163,1365368 (-) STRAND
47% to CYP158A3
gene = rppB
red pigment gene cluster
CYP159A1 Streptomyces coelicolor cosmid F55
GenEMBL AL132991 CDS 6235..7458
41% to 107K1 41% to 134 new family
cloned and expressed by David Lamb and Steve Kelly
CYP159A2 Streptomyces hygroscopicus subsp. yingchengensis
GenEMBL AY260760 983..2209
84% to 159A1
gene = shy1
MSAAHHLPDILSPEFAANPYPAYAVMREKEPLIWHEATQSYIIS
RYEDVERVFKDKKAEFTTDNYNWQLEPVHGKTILQLSGREHAVRRALVAPAFRGSDLE
QKFLPVIERNSRELIDAFRHTGSADIVNDYATRFPVNVIADMLGLDKADHARFHGWYT
AVIAFLGNLSGDPEVAAAGERTRVEFAEYMLPVIRERRANPGDDLLSTLCAAEVDGVR
MSDEDIKAFCSLLLAAGGETTDKAIAGILANLLSHPDQLAAVRADRSLIPAAFAETLR
YTPPVQMIMRQSATDVEVTGGTIPAGATVTCLIGAANRDERRYRDPDRFDIFRDDLAT
TSAFSAAAGHLAFALGRHFCVGALLAKAEVEVGLNQLLDAMPDLRLADGHDLVEQGVF
TRGPKTLPVRFTPVTA
CYP159A3 Frankia alni ACN14a
YP_710491
CAJ58879
52% to CYP159A1 Streptomyces coelicolor
53% to CYP159A2 Streptomyces hygroscopicus subsp. Yingchengensis
MTTTPTTVPEKPDVLSAEFARDPHTYYKIMRDFYPVLHHEVSGYYFVSRY
EDVARIYKDSVGFSNENYAFQMEPVIGKTVIQMGGREHAINRQLITPALR
GNYLEELLPQVDELATEMIDKFRTAGRVDLAEDFTKWFPINVIVKMLDLP
REDLPKFHEWYSSLMAFLANLTNDPEIHAWGMRTQQEYPAYILPIIAERR
RNPGTDLISRLTQAEINDEQFSDEQIKALIGLLLIAGGETTDKSIASTLK
YLIMHPEQLEAVRQDPSLATRALVETLRYHPPVQIILRTTTDDVEVAGTV
IPVGSVVGCVNGAANRDERRFDDPDTYNIFRTDINIRQAFAGSADHIAFA
LGRHFCVGSLLAKREAETAINQILAAMPDIRFADGIEPTDAGLFTRGPES
LIVEFTPAS*
CYP159A4 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE2759 76% to CYP159A1
CYP159A5 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR4391
84% to CYP159A1
CYP160A1 Streptomyces lavendulae LinA homolog.
GenEMBL AF127374 CDS complement(43595.44782)
gene="mmcN" 39% to D87924 new family
CYP161A1 Streptomyces noursei ATCC 11455 nyst.
GenEMBL AF263912 CDS 57095.58279 gene="nysL"
function="presumably involved in modification of the
nystatin macrolactone ring" 36% to AF127374 = new family
CYP161A2 Streptomyces natalensis
GenEMBL AJ278573 81418..82611
pimaricin biosynthetic gene cluster.
58% to 161A1
gene = pimD
MTAASHDLPCLNLEPPKMLKLSPLLRALQDRGPIHRVRTPAGDE
AWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLDLLISDADAESGRRQHAETR
RLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGDLHGELTVPFALTVLCEVIGV
PPQRRAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLNDGE
LTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPDVMARAVEEVLR
TARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAARTPN
PHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPVEQLRLKEGQLSGGFAELRVVW
CYP161A3 Streptomyces nodosus
GenEMBL AF357202 56829..58019
gene = amphL
amphotericin biosynthetic gene cluster
71% to 161A1
note = probably hydroxylates amphotericin precursor at C-8
MVNPTPPPSLEDAAPSVLRLSPLLRELQMRAPVTKIRTPAGDEG
WLVTRHAELKQLLHDERLARAHADPANAPRYVKSPLMDLLIMDDVEAARAAHAELRTL
LTPQFSARRVLNMMPMVEGIAEQILNGFAAQEQPADLRGNFSLPYSLTVLCALIGIPL
QEQGQLLAVLGEMATLNDAESVARSQAKLFGLLTDLAGRKRAEPGDDVISRLCETVPE
DERIGPIAASLLFAGLDSVATHVDLGVVLFTQYPDQLKEALADEKLMRSGVEEILRAA
KAGGSGAALPRYATDDIEIADVTIRTGDLVLLDFTLVNFDEAVFDDADLFDIRRSPNE
HLTFGHGMWHCIGAPLARMMLKTAYTQLFTRLPGLKLASSVEELQVTSGQLNGGLTEL
PVTW
CYP161A4 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY1472 57% to CYP161A1
CYP161B1 Streptomyces sp. Tu6071
ABB69759
PlaO4
1 MAAQIQLPLD PPHPARPQHN LRALQKRAPV HRVSTAVGDP AWLVTGYQEI KQLLADPRLG
61 RSHHDPENAA RSGASELLDG PRGDYDTEQK WIATMRSRLQ PFFSAGHVKA MRPRVEALVG
121 ELLDRLEKQG PPADLAEALA LLLPREVIGE LLGVPVEERE LLDEWTTAVS DARDRERSAA
181 GLAALHRYGH ELAARKRAHP TQDVVSWLCE DGTLSDDQVA QLAMGVLFAG YETTATALCV
241 GTALLLDSPE QWRALRENPG LAPTAAEESV RVVSRLLPPV IRYTREDLEI AGAEVRRGEL
301 VMLDIYAATH DESIFPDPDR FDITREDNPH LCFGFGLRYC IGAPLARLEL QAALTQLTTR
361 FPRMRLTVPV EDLTVRPGSF AAIPTSLPVI W
CYP161C1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_10607
42% to CYP161B1 Streptomyces sp. Tu6071 ABB69759
40% to CYP161A2 Streptomyces natalensis
CYP161C2 Streptomyces arenae TU469
HQ292065
David E. Cane
Submitted to nomenclature committee Nov. 28, 2010
Gene name PntM
Catalyzes the oxidative rearrangement of pentalenolactone F
To the antibiotic pentalenolactone
89% to CYP161C1
CYP161C3 Streptomyces exfoliatus strain UC5319
HQ292066
David E. Cane
Submitted to nomenclature committee Nov. 28, 2010
Gene name PenM
Catalyzes the oxidative rearrangement of pentalenolactone F
To the antibiotic pentalenolactone
84% to CYP161C1
CYP162A1 Streptomyces tendae nikkomycin
AJ250199 CDS 22..1212 gene="nikQ"
38% to AF170880 new family
CYP162A2 Streptomyces ansochromogenes
AF322179.3
nikkomycin biosynthesis gene cluster
gene SanQ
96% to 162A1
CYP162B1 Saccharopolyspora erythraea NRRL23338
SACE_4920, se: 5495967,5497184 (-) STRAND
41% to 162A1 NikQ in nikkomycin biosynthesis gene cluster
41% to 162A2 AF322179.3 Streptomyces ansochromogenes
nikkomycin biosynthesis gene cluster SanQ (96% to 162A1)
VIQAPTVDLTDPELFSSNRFWEVLAWLRANDPVHWHPDAEGSGFWVVTRYDDVTAVYADA
ETFSSRFGMRLGSNDDAVSAVSQRMLIVSDPPDHTHLKRVLSKTFGGSEMSRLEGLVRDV
VREVVADAVEAGETDFLDVAKLIPNYVVCAVMDLPREDWAWVGRTTTDAFEGEDEETRSG
AHGEIFLYFDDLLRQRRGGSGEDFISRVARDRRATDVPDQDRLLTDEEIVFNCNGVLAGA
NETTRYSTAGGVLALAENPDQWRKLREGGAAAIPAAVEEILRWTVPGVHALRTATRPATI
RGQSIGVGDRVTIWNVSANRDEAVFADADSFVVDRSPNRHITFGAGRHLCLGARLARLEL
SAFLSELLDRVEEIELCGEPQYNASNFTWGLRELPVRLVRKQKVP
CYP162C1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR582
42% to CYP162A1
CYP163A1 Streptomyces spheroides novobiocin
AF170880 CDS 9688..10911 gene="novI"
38% to AJ250199 new family
CYP163A2 Streptomyces roseochromogenes subsp. oscitans
AF329398 15196..16419
Clorobiocin biosynthetic gene cluster
90% to 163A1
gene = cloI
MSTRPTVSPDELEQIDLASPILHAEYELGEVFRYLRANRPMYWQ
QPRGEQPGFWVISRYADVNEVYKDKAHFTTEHGNALATLLTGGDSASGAMLAVTDGVR
HHQVRNLLSKGFSPQMLDLIANSLRETVDGLLLAALDRGECDAAQDIAANVPLGAICD
LLEIPQTDRKYLLGLTAHAWSTDYADETPEEGWVAKNEILLYFSKLLKERRGGDRDDM
VSLLANCRIDGHPLNAAEQVANCYGLMIGGDETGRHAITGTILALIENPDQWRALKNG
DVDLKTATEEALRWTVPSLHGGRKATGDVVINGQQIKAGDVVSVWISSANRDEAIFDA
ADEFKLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYS
SILHGMSSLPIRITV
CYP163A3 Streptomyces antibioticus
GenEMBL AF322256 22228..23478
simocyclinone biosynthetic gene cluster
62% to 163A1
gene = simI
MNPRPMLSPDVLEDIDLNDRQLHADYDLSEVWRYLRAERPFYYQ
TARGSQPGFWVVTRHADCTAVYKDKTNFTAERGNVLPTLLAGGDSASRTMLALTDGDR
HTQVRNLLMKAFSPKMLSNIGQSLRTTVDGLLRDAIEKGECDFARDVSGKVPLVAICD
LLAVPQEDREYLLSLTAHALSADEADATAEDNWTAKNEILLYFADLAESRRSSGHNDV
VSLLATSSIEGEPLSDGELMANCYGLMIGGDETGRHAITGGLRALIHHPDQWRMLRNG
EADLQTATEEVLRWTVPSLHGARTATADVVVNGKQQIRAGEIVSVWFASANRDEEVFR
DADRFDLNRTPNKHLTFAFGPHFCLGHYLARMEVEAILDGLRRMVDDIQQTGPEKLIY
SSILQGISSFPALLKPDRRVPPQT
CYP163A3 Streptomyces antibioticus
GenEMBL AF324838 26497..27762
simocyclinone biosynthetic gene cluster
gene = simD1
note="involved in aminocoumarin formation"
same seq as AF322256 except this seq has MKGTM added
at the N-terminal (a disagreement on start codon)
CYP163B1 Salinispora tropica (marine actinomycete)
Strop_1021 complement(1150011..1151288)
46% to CYP163A3 Streptomyces antibioticus
MTAADTGRVGSGESQTPAHTVDLADPATFANHDLTGFWQQLRDEEPIHWNPPTAGRRGFW
VVSRYADILDVYRDDVTFTSERGNVLVTLLAGGDAGAGRMLAVTDGPRHAELRKLLLRAL
GPRVLAPVCAAVRTNTRQMIREAVTKGECDFASDIASRIPMMTISNLLGVPDADRAFLLS
LTKTALSADDESISETESAMARNEILLYFQDLMEFRRDHPGEDVVSMLVNSSIDGAPLSD
DDIVLNCYSLIIGGDETSRLTMIDSVNTLAAHPQQWRRLKDGQCEIDKAVDEVLRWASPS
MHFGRVAARDTILHGVRIRADDIVTLWHASGNRDERVFHRPEVFDLGRTPNRHLSFGHGP
HYCIGSYLAKVEISELLIALRDLTSGFETTGEPQRIRSNLLTGFATMPVRFVPDRAGLAR
DALDG
CYP163B2 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR3267
56% to CYP163B1
CYP163B3 Streptomyces sp. Acta 2897
EMBL AEA30275.1
UniProt tr|F2YRY7|F2YRY7_9ACTO P450 monooxygenase
sky32 for making skyllamycin
62% to CYP163B2 SGR3267 Streptomyces griseus
56% to CYP163B1 Salinispora tropica (marine actinomycete)
51% to CYP163C1 SBI_8210 Streptomyces bingchengensis
48% to CYP163A1 Streptomyces spheroides novobiocin
49% to CYP163A2 Streptomyces roseochromogenes subsp. oscitans
49% to CYP163A3 Streptomyces antibioticus
MTAHTLPIPDDISTINLTDPRTYEVNDLSEYWRQLRTTRPLYWHPPVGDAPGFWVVSRYA
DVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSFSPQALK
PIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLGVPAADREFLLKLNKSAL
SSEDADQSATDAWLARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLN
CYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVTLESATEEVLRWATPAMHFGRR
AVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPNKHITFGYGPHFCLGA
YLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQPNEAAIAAYDSDNG
VRS
CYP163C1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_8210
49% to CYP163A3 Streptomyces antibioticus
CYP164A1 Mycobacterium leprae cosmid B1788
GenEMBL AL007924 CDS complement(38296-39228)
40% to AL049754 partial
CYP164A1 Mycobacterium leprae
GenPept CAC31043
NC_002677 complement(2481544..2482848)
locus_tag = ML2088
100% match but this is complete
1 MRTCVPTRTC VYAFIEYLSH NRPMGTNPPS LVEAQMLLLR LIDPGTRADP FPVYRALIDY
61 GPMQLPGMPL TVFSSFSDCD EALRHPLSAS DRLKATLAQQ AIAAGAEPRP FYASSFMFLD
121 PPDHTRLRKL VSKAFAPKVV QALEGDIAAL VDSLLDKGAA AGQFDVIADL AFPLAVAVIC
181 RLLGVPYEDA PEFGRVSALL VQSVDPFITI TGEPPEATEE RLRAGVWLRD YLEQLVKCRR
241 GTPGEDLISR LIELDESGDQ LTEEEIIATC GLLLVAGHET TVNLIANAVL AMLRNPSQWK
301 ALSSNPQRAP LVVEETLRYD PAIHLIGRVA AKDMTIGQTT LTEGDTMVLL LAAANRDPAV
361 YSRPDEFDPD RPSSRHLAFA VGSHFCLGAA LARLEATVTL SAISARFPQV QLAGELVYKP
421 NVAMRGMSAL PVQV
CYP164A2 Mycobacterium smegmatis
MSMEG6272 TIGR
61% to CYP164A1
67% to CYP164A4 Mycobacterium vanbaalenii
66% to 164A3
MHNGWMSTAATAQEAQGLLLQLLDPATRADPYPIYDRIRRGGPLALPEAN
LAVFSSFSDCDDVLRHPSSCSDRTKSTIFQRQLAAETQPRPQGPASFLFL
DPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDGPEFNLIDNL
AYPLPVAVICRLLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDE
QMKAGMWLRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATC
NLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRASAVIEETMRYD
PPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD
RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR
NLTLRGMSTLSIAV
CYP164A3 Mycobacterium marinum
No accession number
Tim Stinear
MM5268
57% to 164A1
CYP164A3P Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 164A3 M. marinum in conserved region
CYP164A4 Mycobacterium vanbaalenii PYR-1
ZP_01206517.1, EAS24279.1
60% to 164A1
MRLLHLHALHPRVSAPLVQGQGDAVRDAVHDPQRAVRHPPRRRHPRRHPRGPVRRAARARPRPVLRQGVA SAGVFDLHPFRLVHNKSMTTAAEPQSLLLQMLAPEVRADPYPVYAQILAHGPMQLPGNNLTVFSSYADCD EVLRHPDASSDRLKSTAAQRAIADGAEARPFGPPGFLFLDPPDHTRLRWLVSKAFVPKVVKALEPDIVTM VDGLLREAEAGATFEAIGGLAYPLPVAVICRLLGVPLEDEPQFSAASALLAQSLDPFISVTGSAGSGFEE RMQAARWLRGYLRELIARRRRDPGEDLMSGLIHVEESGDQLTEDEIVATCNLLLVAGHETTVNLIANAIL ALLRNDGQWAALAADPGRAAAVIEETLRHDPPVQLVGRIAGQDMTIGGERSDGGNVAGGVTVPKGDNILL LTAAAHRDPDHVDRPDEFDPDRPVIRHLGFGKGAHFCLGAPLARLEATLALTALTSRFPDAKLAAEPVYK PNVTLRGMSELSITLA
CYP164A5P Mycobacterium leprae cosmid B1450
GenEMBL AL035159.1
45% to 164A1 C-term region before heme binding seq
AVDALLCFLSPPGLAGPRFAVTDVEIGQHTVVAGQTVRLYLASANHDPQRFNCTDELEPTRPAPHTA
CYP164B1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
45% to 164A1 missing about 112 aa at N-term
clone name SP0831
CYP165A1 Amycolatopsis mediterranei
Y16952 CDS 224..1399 gene="oxyA"
85% to AJ223999 CDS 31325..32500 42% to Y16952 CDS 1449..2645
41% to AJ223999 32520..33740
CYP165A2 Amycolatopsis orientalis cosmid PCZA363.
GenEMBL AJ223999 region 31325-32500
van Wageningen,A., Kirkpatrick,P., Williams,D., Harris,B.,
Kershaw,J., Lennard,N., Jones,M., Jones,S. and Solenberg,P.
Sequencing and analysis of genes involved in the
biosynthesis of a vancomycin group antibiotic
Unpublished
CYP165A3 Amycolatopsis orientalis
GenEMBL AF486630
Zerbe,K., Pylypenko,O., Vitali,F., Zhang,W., Rouset,S., Heck,M.,
Vrijbloed,J.W., Bischoff,D., Bister,B., Sussmuth,R.D., Pelzer,S.,
Wohlleben,W., Robinson,J.A. and Schlichting,I.
Crystal Structure of OxyB, a Cytochrome P450 Implicated in an
Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
J. Biol. Chem. 277 (49), 47476-47485 (2002)
oxyA
84% to CYP165A2
MFEEKNALRGTEIHRRERFDPGPELRALMAEGRMSVMESEESPG
GRTGWLATGYEETRQVLGSDKFSAKLLFGGTAAGRIWPGFLNQYDPPEHTRLRRMVAS
AFTVRRMRDFRPRIEAVVKATLDDIEATGGPVDFVPRFAWPIATTVICDFLGIPRDDQ
AELSRVLHASRSERSGKRRVAAGNKYWTYMGQVAAKTRRDPGDDMFGAVVREHGDDIT
DAELLGVAAFVMGASGDQVARFLSAGAWLMVEHPEQFAVLRDDPDSVPDWLNEVARYL
TSDEKTTPRIALEDVRIGDQLVKKGDAVTCSLLASNRHRFPDPEDRFDITREKPSHVT
FGHGIHHCLGRPLAEMVFRTAIPALAHRFPTLRLAEPDREIKLGPPPFDVEALLLDW
CYP165A4 Streptomcyes toyocaensis strain NRRL 15009
GenEMBL U82965 AF039028 complement(11438..12613)
72% to CYP165A1
MFEEINVVRASQLHRRDRFDPVPELHSLMKEGGLTVLGTEDSTE
GRTAWLATGIDEVRQVLGSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVP
AFSHRRMQKFRPRVEQIVQDSLDTIESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQ
ADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAIT
DAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVPEWLDETMRYL
TTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPNYPSAEDEFDITREKAEHLA
FGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPPFDVEALLLDW
CYP165A5 Actinomadura sp. ATCC 39727
GenEMBL AJ561198 complement(23387..24568)
gene = dbv14
gene cluster for biosynthesis of
glycopeptide antibiotic A40926
function="cross-linking of amino acids 2 and 4"
72% to 165A1
MEVFEELNVVLPGELHWRDRFDPVPQLRSFMAEGPMTELGAEEG
PGGRTAWLATGFDEVRQVLGSDKFSSRLLYGGTAAGIVFPGFITQYDPPEHTRLRRVV
SPAFTVRRMERFRPQVDQVVEDCLDAIESIGGPLDFVPHFGWSIATTATCDFLGIPRD
DQAELSRSLHASRSQRAASRRGAAGNKFMTYMGQVVARTRRDPGDDMLSVVVREHGDE
ITDAELTGLAAFVMGAGGDQVARFLAAGAWLMAEVPEQFALLRDKPDVVPDWLEEMVR
YLTIDEKLTPRIALEDVRIGDRIVKAGDTVTCSLLGANRRHFPGPDDQFDLTRDRAPN
VAFGHGIHHCLGRPLAELIFRSAIPALARRFPALRLAEPEQEIRLGPPPFDVKALLLDW
CYP165A6 Actinoplanes teichomyceticus
Genpept CAG105017
GenEMBL AJ632270 CDS 47098..48273
teicoplanin gene cluster
80% to CYP165A4 Streptomcyes toyocaensis strain NRRL 15009
MFEEINVVRAAELHRRDRFDPVPQLRSLMAEGPLTTLGTEESPG
GRTAWLATGYDEIRQVLSSDDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVAP
AFAVRRMQKFQPQVERVVQDSLDAIEALGGPVDFVPRFGWSVATTATCDFLGIPRDDQ
ADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVREYGDEIT
DAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTVPDWLDEVIRYL
TTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANRRNFPRPEDRFDITRVRPEHLA
FGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGPPPFDVEALLLDW
CYP165B1 Amycolatopsis mediterranei 9.9kB DNA
Y16952 CDS 1449..2645 gene="oxyB"
87% to AJ223999 32520..33740 47% to Y16952 CDS 2795..4015
47% to AJ223998 gene 1 53% to U84350 partial
CYP165B2 Amycolatopsis orientalis cosmid PCZA363.
GenEMBL AJ223999 region 32520-33740
van Wageningen,A., Kirkpatrick,P., Williams,D., Harris,B.,
Kershaw,J., Lennard,N., Jones,M., Jones,S. and Solenberg,P.
Sequencing and analysis of genes involved in the
biosynthesis of a vancomycin group antibiotic
Unpublished
CYP165B3 Amycolatopsis orientalis
GenEMBL AF486630; AAL90878.1
Zerbe,K., Pylypenko,O., Vitali,F., Zhang,W., Rouset,S., Heck,M.,
Vrijbloed,J.W., Bischoff,D., Bister,B., Sussmuth,R.D., Pelzer,S.,
Wohlleben,W., Robinson,J.A. and Schlichting,I.
Crystal Structure of OxyB, a Cytochrome P450 Implicated in an
Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
J. Biol. Chem. 277 (49), 47476-47485 (2002)
Zhang W., Zerbe K., Vrijbloed J.W., Robinson J.A.
DNA sequence coding for P450 monooxygenases of vancomycin producer
87% to CYP165B1 and 85% to CYP165B2
MSEDDPRPLHIRRQGLDPADELLAAGALTRVTIGSGADAETHWM
ATAHAVVRQVMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRK
LTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPR
DDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYG
DDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQRAVDEL
IRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREP
IPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLT
ELMVAW
CYP165B4 Streptomcyes toyocaensis strain NRRL 15009
GenEMBL U82965 AF039028 complement(9077..10273)
77% to CYP165B1
MSGDDRPPIHTLRQGFDPADELRAAGELTRVRLGSGADAEHTWL
ATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELVGNLMDYDPPEHTRLRRL
LAPGFTHRKIRRMAPYIEQIVTERLDEMEREGSPADLIELFADEVPGPVLCELLGVPR
DDRAMFLQLCHRHLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHG
DTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPAAERAVDEL
IRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREA
VPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATEFRLSTPAYGIS
RLMVTW
CYP165B5 Streptomyces lavendulae
GenEMBL AF386507 42222..43493
complestatin biosynthetic gene cluster
58% to 165B1
note = ORF11; comO2
MPQQAQRQAPQQQPRAQQAYPELLYTRRTRFDPADDLRAAPPLS
RYVIGPNESDEWVWLATGYTEVRRILGDHTNFSTRRRWGAEGPNWRPPELVGHLMDYD
PPEHTRLRQMLTPEFTVRRLRRLEPDITAIIEEHLDTVEATGPGADLMPLFAQPVPGE
VLCELIGVPRDDRPEFLRHCHRHLDFSRSRKVRAADGAAFSRYLVSMVARQRKDPDDG
FIGALVREHGDDFTDEEMRGVCVLLILAGIDNIEGMIGLGVLAMLENPDQLPLLLGER
DSTGGPGAGKGDGGRLASDRALDELIRYMSVANAPTPRTAVNDVRIGDQLIKAGETVI
CSLTMANRDPALTDGPDRLDLAREPVAHVAFGHGVHHCLGAALARTELRIAYKALWRR
FPELRLAVPVEEVRFYNRALAHGVHRLPVAW
CYP165B6 Actinomadura sp. ATCC 39727
GenEMBL AJ561198 complement(21025..22221)
gene = dbv12
gene cluster for biosynthesis of
glycopeptide antibiotic A40926
function="cross-linking of amino acids 4 and 6"
84% to 165B2
MSGDGARPLHTRRQDLDPADELRAAGTLTRITIGSGADAETTWL
ATGYTVVRQVLGDHRRFSTRRRWNERDEIGGRGNFRPRELVGNLMDYDPPEHTRLRQK
LTPGFTLRRIRRLKPYIEQIVTERLDALERAGPPADLVELVADEVPGAVLCELIGVPR
DDRAMFMQLCHGHLDASRSQKRRAAAGAAFSRYLLAMIARERKDPGEGLLGAVLAEYG
DTATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIAALQGDDQSADRAVDEL
IRYLTVPYAPTPRVAMEDVTIGGQVIKEGETVSCSLPMANRDPALLPDAGRLDVRREP
VPHVAFGHGVHHCLGAALARLELRTVYTALWRRFPTLRLADPDREPSFRLTTPAYGLT
SLMVAW
CYP165B7 Actinoplanes teichomyceticus
Genpept CAG105019
GenEMBL AJ632270 CDS 49590..50636
teicoplanin gene cluster
82% to CYP165B4 Streptomcyes toyocaensis strain NRRL 15009
MRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPP
EHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGPPADLIELFADEVPGAVL
CELIGVPRDDQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFI
GSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS
ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDAD
RLDVTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRT
STPAYGLTSLLVAW
CYP165C1 Amycolatopsis mediterranei 9.9kB DNA
Y16952 CDS 2795..4015 gene="oxyC"
90% to AJ223998 gene 1 89% to U84350 partial
47% to AJ223999 32520..33740
47% to Y16952 CDS 1449..2645 40% to AJ223999 CDS 31325..32500
CYP165C2 Amycolatopsis orientalis hypothetical
U84350 CDS <1..935
92% to AJ223998 gene 1 new family
CYP165C3 Amycolatopsis orientalis cosmid PCZA363.
GenEMBL AJ223999 region 33791-34244 incomplete
This gene continues on AJ223998
van Wageningen,A., Kirkpatrick,P., Williams,D., Harris,B.,
Kershaw,J., Lennard,N., Jones,M., Jones,S. and Solenberg,P.
Sequencing and analysis of genes involved in the
biosynthesis of a vancomycin group antibiotic
Unpublished
CYP165C4 Amycolatopsis orientalis
GenEMBL AF486630
Zerbe,K., Pylypenko,O., Vitali,F., Zhang,W., Rouset,S., Heck,M.,
Vrijbloed,J.W., Bischoff,D., Bister,B., Sussmuth,R.D., Pelzer,S.,
Wohlleben,W., Robinson,J.A. and Schlichting,I.
Crystal Structure of OxyB, a Cytochrome P450 Implicated in an
Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
J. Biol. Chem. 277 (49), 47476-47485 (2002)
OxyC
93% to CYP165C2 83% to CYP165C3
MGHDIDQVAPLLREPANFQLRTNCDPHEDNFGLRAHGPLVRIVG
ESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDP
PEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHA
LCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGL
LGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPE
KAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDP
DVLDANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYR
SAFVDCPDQVPVTW
CYP165C5 Streptomcyes toyocaensis strain NRRL 15009
GenEMBL U82965 AF039028
complement(6312..7490)
70% to CYP165C3
MRRTLCDPHEDMFALRAHGPLIRIEGNASDQMSTDYVWQAMGYD
VVRKILGDHENFTTRLRLTDAQPLSGEGVSVPPELAGQISIYDPPEHTRLRRMLTPEF
TVRRIRRLEPAIEGIIEEHLDALEGAGPPADLQVLFADPVGGETLCELLGVPRDDRNE
FIRRVRQNVDLSRGYKARAADSAAFNRYLMTLITRQRKDPDEGFLGMLVREHGDRITD
EELKGVCTALILGGVESVAGMIGFGVLALLEHPDQRRLLFGSREEADRLVNELLRFLS
AVQQPTPRMAVRDVVVEGQLIKAGEYVLCSILMANRDEGLTSDSHLLDANREPLPHVA
FGHGIHHCIGAAVARAVLRITYQSLWRRFPRLSLAVPAGEVKFRNAFIDSPDRLPVTW
CYP165C6 Actinomadura sp. ATCC 39727
GenEMBL AJ561198 complement(19681..20943)
gene = dbv11
gene cluster for biosynthesis of
glycopeptide antibiotic A40926
function="cross-linking of amino acids 5 and 7"
76% to 165C5
MRIDSEWSFDPGMDDDIDAGAPVLQPTANYMMRTHCDPHEDMFA
LRAHGPLVRIGGDAATQLRVDYVWQALGYDVVRRILGDHENFTTRPRWSSAPSIAGEP
IPPNLVGQLSVYDPPEHTRLRGMLTPEFTARRIRRLEPAMQDLIDDRIDELEAAGPPA
DVQALFADPVGGGVLCELLGIPRDDRIEFIRRVRQNVDLSRGFKARAADSAAFNRYLN
GLIIRQRKDPDEGFIGMLVREHGDDVTDEELKGVLTALILGGVETVAGSIGFGVLALL
DHPDQRQSLFAGREEADRVVGELLRFLSPVQQPNPRLAVRDVVVDGQLIKAGDYVLCS
ILMANRDEALTPNANVLDVRRDCGSHVGFGHGIHYCIGAAIARTLLRMAYQSLWRRFP
GLRLAVSAEEVKFRNAFIDCPDELPVTW
CYP165C7 Actinoplanes teichomyceticus
Genpept CAG105021
GenEMBL AJ632270 CDS 52502..53746
teicoplanin gene cluster
78% to CYP165C6 Actinomadura sp. ATCC 39727
MFTGMDHDIDEVAPVVEPTANYMRRTVCDPHEDMFALRAHGPLI
RIGGDAAVQMGADYLWQAMGYDVVRQILGDHENFTTRLRLTASEPISGEGATKPQELV
GQISTYDPPEHTRLRRMLTPEFTVRRVRRLEPAIQELIDDRIDAMEAAGPPVDVQTVF
ADPVGGGALCELLGIPRDDRNQFMRRVRQNVDLSRGYKARAADSAAFNRYLQSLITRQ
RKDPDEGFLGMLVRDHGDDITDEELKGVCTALLLGGVETVAGMLGFGVLALLDHPDQR
RLLFAGREEADRLVNELLRYLSAVQQPTPRMAVKDVVVDGQQIRAGEYVLCSILMANR
DEALTPHPNVLDAEREPAPHIGFGHGIHHCIGAAVARTVLRMAYQTLWRRLPGLRLAI
PAGQVKLRNAFIDSPDQLPVTW
CYP165D1 Streptomcyes toyocaensis strain NRRL 15009
GenEMBL U82965 AF039028 complement(10263..11417)
45% to CYP165A3
MALPLPHRRHRLDPVPEFHDLQNEGPLHEYDTEPGMDGRKQWLV
TGYHEVRDILADPERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDLEDVGSPVDFVRYAAWPIPALIACEFLDVPRDDRAELSRM
IRESRESRLPRQRTSSGMGVVNYTQKLAARKRLDPGEGMIGVIVREHGAEVSDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREHPELVDGATEELLRHASIVEAP
APRVALEDVSVAGRDIRAGDVLTCSMMAVNRPQGEHFDITRENPKHMAFGYGIHHCLG
APLARLQLRVALPAVLRRFPSLRLAVPEEDLRFKPGRPAPFAVEELPVEW
CYP165D2 Actinomadura sp. ATCC 39727
GenEMBL AJ561198 complement(22211..23365)
Gene = dbv13
gene cluster for biosynthesis of
glycopeptide antibiotic A40926
function="cross-linking of amino acids 1 and 3"
75% to 165D1
MVVPLPHQRLRLDPVPALFDLQEDGPLHEYDTEPGLDGHKQWLV
TGYGEIREILADANRFSSMRPVEDEAERAWLPGILQSYDAPDHTRLRRTVTRANTARR
IESLRPVVEETVEDCLADLESMGSPVDFVRNAAWPIPALIACDFLGVPRDDQAELSRM
FRDSRESRVPRQRNVSGLGIVDYARKLAARERLDPGTGMIGGIVREHGGEVTDEELAG
LVEGIMIGAVEQMASQLAIAVLLLVTHPDQMALLRERPELADSAAEEVFRYASIVETP
SPRTALVDTRLAGRDIHAGDVLTCSILAGNRAREDRFDLTRGNPEHLAFGHGVHFCLG
APLARLQAQVALPALVRRFPSLRLAVPAEDLRFKPGKPAPFAVEELPVEW
CYP165D3 Actinoplanes teichomyceticus
Genpept CAG105018
GenEMBL AJ632270 CDS 48296..49450
teicoplanin gene cluster
86% to CYP165D1, 75% to CYP165D2
MALPLPHQRLRLDPVPEFEELQKAGPLHEYDTEPGMDGRKQWLV
TGHDEVRAILADHERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDFESVGAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELSRM
IRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELIDSATEEVLRHASIVEAP
APRVALADVRMAGRDIHAGDVLTCSMLATNRAPGDRFDITREKATHMAFGHGIHHCIG
APLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPGRPAPFAVEELPLEW
CYP165E1 Streptomyces lavendulae
GenEMBL AF386507 41015..42208
complestatin biosynthetic gene cluster
45% to 165B1
note = ORF10; comO1
MASRDVPVYNRRDRLDPVPELVELRNRCPVLRTELHGGPSSQVV
GWLVTGIDESREVLSDQHRFTMLPPADTEAQSRRLQNIGNPLHYDPPEHTRLRKMLNP
EFTMRRLRRLQPRIDAVVEECLDAMEQAGAPADLMQHFAWQIPGHTACELLGVPRDDR
AELSRHLDITRDDGRGRARQMAAGRAYRAYFHQLTARQRRDPGDDLLGMLVREYGDEI
TDEELEGLAASLTSAGIENVASMLGLGTLVLLEHPDQLAELREKPELIDRAVEELLRH
VSVIPTLSPRTALEDVPLGGHVVPKGERVICSAFAANRIATPGDDLEDGFDITREPAP
HMAFGHGVHHCLGAPLARMQLRTAYQALWRRFPELRLAVPHEEIRFRMPSSRVYSVDA
LPVAW
CYP166A1 Amycolatopsis mediterranei rifamycin.
AF040570 CDS 2652..3842 identical to AJ223012
similar to Streptomyces Sp. ChoP"
probably a new family 41% to 105C1 but less to other 105s
CYP166B1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
46% to 166A1
clone name SP0879
CYP167A1 Sorangium cellulosum = Polyangium cellulosum
AF210843 CDS 62369..63628 gene = epoF
35% to 107B1 new family
CYP167A1 Sorangium cellulosum = Polyangium cellulosum
GenEMBL AF217189 56757..58016
epothilone gene cluster
gene = epoK
note = P450 epoxidase
CYP168A1 Pseudomonas aeruginosa
NC_002516 complement(2792798..2794132)
locus_tag = PA2475
35% to 107P1
MDDAFSEEGSAQPRHDAQRPALAPRSDGFDIHTYHPDFVADPYP
LLRLIRSRAPVCRDQASIWWISRYADVSACLRDRRFSADPARLGAAGVRQGGASWFGH
QQLQPLARFYDNFMLFNDAPRHTRLRRLFAPAFGPDAVRRWEARIEVLVEELLDSLLE
RREPDLLRDFAEPLTIRVAAELFGFPREDTGQLLPWGRDLAAGLDLAASHGDAGQINR
SAVAFSDYLQRQARGWSDGSSRPPSGAAPSILDGAAMLEAGLGLEDLVAAYAMVFMAA
FETTISMVGNATLALLTHPDQLDLLRRCPELAANAVEELLRFDGAVRGGVRCTLEEVE
IGGQRIPPGEKVWLSFLAANRDPEMFAAPDRLQLQRANAKQHVAFAHGPHYCLGAYLA
RLELQCALRGLVRRRFALASEPTDLRWRRSSVFRTLERLPIVPEGDAQKTCE
CYP169A1 Pseudomonas aeruginosa
NC_002516 complement(4121113..4122390)
locus_tag = PA3679
MQQTIDCPIRRRLAHLPWANDGRAGVRHWLEMQRDPLAWLQKMH
VAQPDLAVARMGPQRLWCLFHPQAVQELMVDRRDDLQRWQPALCMLKQWNGRSFMMRE
GAPAQARRKEVRPHLAPPPASEVRRLAAEWGERVEEGREYDLDLEMAAFSVTLSGHAL
FDVDLQPSAYRIAKAVRLLSRVALLEMSTGLPLGHWFPSKLCPRKRWALGQLREAVGE
VAERSPRPLADLRDELCTLLMASHQSTGVTLTWSLLLLAQRPELLARLRAELAGVNWT
AIRSVADLRDCALLRAVLQECLRLYPPAYGLAPRQVTADIEVFGQRLKRGDVTMVSSW
ITQRDPRWFEAPLEFRPERFLEPARWPRGAYFPFGLGDRACPGTAMAMIDLAAALAYW
VEHWDIMHDGDLAPRGWFSLRPQRARVRFRRRA
CYP170A1 Streptomyces coelicolor cosmid 7E4 gene="SC7E4.20
GenEMBL AL359214 CDS 18278..19663
32% to Streptomyces avermitilis CYP171A1
cloned and expressed by David Lamb and Steve Kelly
CYP170A2 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV3031 79% to CYP170A1 from Streptomyces coelicolor
CYP170A3 Streptomyces lividans
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
99% to CYP170A1 Streptomyces coelicolor (ortholog)
CYP170A4 Streptomyces viridochromogenes
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
85% to CYP170A1 Streptomyces coelicolor
CYP170A5 Streptomyces ghanaensis
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
81% to CYP170A1 Streptomyces coelicolor
CYP170A6 Streptomyces sviceus
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
80% to CYP170A1 Streptomyces coelicolor
CYP170A7 Streptomyces griseoflavus
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
80% to CYP170A8 Streptomyces sp E14
75% to CYP170A1 Streptomyces coelicolor
CYP170A8 Streptomyces sp E14
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
80% to CYP170A7 Streptomyces griseoflavus
73% to CYP170A1 Streptomyces coelicolor
CYP170B1 Streptomyces albus
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
63% to CYP170B3 Streptomyces SPB78
62% to CYP170B2 Streptomyces SPB74
55% to CYP170A1 Streptomyces coelicolor
CYP170B2 Streptomyces SPB74
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
92% to CYP170B3 Streptomyces SPB78
51% to CYP170A1 Streptomyces coelicolor
CYP170B3 Streptomyces SPB78
No accession number
David Lamb
Submitted to nomenclature committee 9/29/2011
92% to CYP170B2 Streptomyces SPB74
52% to CYP170A1 Streptomyces coelicolor
CYP171A1 Streptomyces avermitilis polyketide synthase gene cluster
GenEMBL AB032367 CDS complement(31914..33284)
gene="aveE"
note="probably catalyzes furan ring formation at C6 to C8
32% to CYP170A1
CYP171A1 Streptomyces avermitilis
GenEMBL AB032367 CDS complement(31914..33284)
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV941_aveE see above entry
CYP171A2 Streptomyces nanchangensis
GenEMBL AY129009
complement(2614..3993)
MeiE; involved in meilingmycin biosynthesis
62% to 171A1
MPAPLQVPDVPGSWPVVGHLPQLARRPLDFLSSLADHGDLVRIR
LGRKPVYVATHPDLVRSLLVTDAHAYTRGAGHAKALAFIGPILVATTGEPHRRQRRMM
QPCFHRQRLGSYVSAMCSAATETADSWSAQDVVDVVPVMTELATAMIAKSLFVSERAA
HAEAELRKTGNAILTVARMSAILPGIYRRLPTPGNRQLPPARTVIEETIAAYRAEGQD
HGDMLSTLLRTTDATGTGLTDEEIRDEVMGLAITGIGGPAAIASWIFYELGQNPDLER
RLHEELDTVLDGRPPSSQDLTRLVFTQRLVKEALRKYPGWVGARRTRESVRLGGHEIP
ADAEVMYSAYALQNDPRWYPDPERFDPDRWDPQQNATRVKKGAWVPFSGGVYKCIGDA
FTETETAVAVAVIASRWRLRPADGRSVRASHLATHVVPRPLRMVVEPRSRNKDEAERS
PHEAPQVSR
CYP171A2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_9777
99% to CYP171A2 Streptomyces nanchangensis
only 2 aa diffs, missing 15 aa at N-term
CYP172A1 Campylobacter jejuni
GenEMBL AL139078 comp(120285-121649)
Parkhill,J., Wren,B.W., Mungall,K., Ketley,J.M., Churcher,C.,
Basham,D., Chillingworth,T., Davies,R.M., Feltwell,T., Holroyd,S.,
Jagels,K., Karlyshev,A., Moule,S., Pallen,M.J., Penn,C.W.,
Quail,M., Rajandream,M.A., Rutherford,K.M., VanVliet,A.,
Whitehead,S. and Barrell,B.G.
The genome sequence of the food-borne pathogen Campylobacter jejuni
reveals hypervariable sequences
Nature 403 (6770), 665-668 (2000)
only 28% to 102A3
CYP172A1 Campylobacter jejuni subsp. jejuni NCTC 11168
GenPept CAB73835
100% match
1 MSECPFFPKP YKNKASTLLT FLLKRRSWLD GLYERSYKMQ TGYVKMPNFD LYVINDTKEV
61 KRMMVDEVRE FPKSAFLHEL LSPLLGESIF TTNGEVWKKQ RELLRPSFEM TRINKVFNLM
121 SEAVADMMDR FSKYPNHAVI EVDEAMTFIT ADVIFRTIMS SKLDEEKGKK ILNAFVTFQE
181 QSVHTAMRRM FRFPKWLSYV LGDCKRAKAG DVIRQVLSDI IKPRYDMADN AEFEDILGSL
241 LLVVDADTNK RFSFEEILDQ VAMLFLAGHE TTASSLTWTL YLLSLYPKEQ EKAYEEITQV
301 LQGGVIEISH LRQFKYLTNI FKESLRLYPP VGFFAREAKK DTQVRDKLIK KGSGVVIAPW
361 LIHRHEEFWT NPHGFNPSRF EGEYKKDAYL PFGVGERICI GQGFAMQEAI LILANILKTY
421 KLELEEGFVP DVVGRLTVRS ANGMRIKFSK RKL
CYP173A1 Mesorhizobium loti
GenEMBL AP003005.1 327049-328782
only 30% to 172A1
CYP173A1 Mesorhizobium loti
GenPept NP_105897
NC_002678 complete genome 4126331..4127698
100% match
1 MDTQPAPFVP PAPKPRTSPP STLEMIRIVY RNPLELWGEP TYNEPWISAN GVGGHLIVAN
61 DPGLIRHVLV DNAKNYKMAT VRQKILRPIL RDGLLTAEGE VWKRSRKAMA PVFTPRHIFG
121 FAQPMLKRTK EFVTRYEEGG ASDIAHDMTL LTYDILAETL FSGEIAGEPG SFANEIDRLF
181 ETMGRVDPLD LLRAPDWLPR LTRIRGRKTM AYFRKIVTDT VKMREEKFRR DPDAVPQDFL
241 TLLLKAEGPD GLTRSEVEDN IITFIGAGHE TTARALGWTL YCLAESPWER NRVEQEIDEV
301 LAREPDPTKW LDAMPLTRAA FDEALRLYPP APSINREPIE PEMWKDLYIP RHAAVLVMPW
361 VVHRHRKLWD RPDAFLPERF HPGNREKIDR FQYLPFGAGP RVCIGASFAM QEAIIALAIL
421 LSRFRFDTTA ETKPWPVQKL TTQPQGGLPM QVTPR
CYP173A2 Sinorhizobium meliloti 1021
Genpept CAC41447
NC_003047 65218..66618 = 173A2
locus_tag = SMc02579
62% to CYP173A1 Mesorhizobium loti
MDTRPEPFEPPAPVPRTGIPSRLEIIRTVLRNPLELWGEPSYTL
PWIETKFINQRTLIVNDPGLIRYILVENAANYEMSNVRRLILRPILRDGLLTAEGEVW
KRSRKAMAPVFTPRHAQGFAGQMLRVCEAFVDRYAGASSEPFVTNVAVDMTELTFEIL
AETLFSGEIAVEKQGFAANVEELLHRMGRVDPMDLLVAPSWVPRLTRIGGRKVLDRFR
GVVSETMSLRRRRTTEAPGDVPNDFLTLLLQLEGPDGLSTSEIEDNILTFIGAGHETT
ARALAWCFYCVANTPAYRETMEQEIDSVLASGADPVDWLGRMPHVLAAFEEALRLYPP
APSINRAAIEEDAWTSPEGERVPIRKGISVLVMPWTLHRHALYWQKPRAFMPERFLPE
NRDKINRFQYLPFGAGPRVCIGATFALQEAVIALAVLMHRFRFDLTDETHPWPVQRLT
TQPRGGLPMKVSARVK
CYP173B1 Magnetospirillum magnetotacticum
GenEMBL AAAP01002719
42% to 173A1 missing N-term 91 aa
1466 NGLLTAEGDEWRLQRRTLAPIFSARHVAGFVAQMDAAGARLGRRLARRDGATVDIALEMT 1287
1286 RATLDVLERTIVHAKGLPGPIPDALGRAITRLLESVGPIDP 1164
1185 SDVFGFPAFVPRLGRLRAGRHCVSSRRW*HLLDGRKQALARGEAPHDLM 1015
1014 TLLLAAQDPETGRGLSDIEVKANIVTFIAAGHETTANALTWALYCLSQDGAARARVEAEA 835
834 DAAAGPEGNLRLDRLPFTKAVMEETMRLFPPVPFLSRQALRDDRIGRVKIPRNSTVIV 661
660 APWVMQRHRKLWDEPDAFIPDRFFGSRRESIERYAYLPFGAGPRVCIGQSFSVQEATLVL 481
480 AHVARAVRFTLPDEHPPVTPLHRVTLRPKDGLRMVARRRM* 358
CYP174A1 Halobacterium sp. NRC-1 (Euryarchaeota; Halobacteria)
GenEMBL AE004998 comp(560-1777)
only 33% to 171A1
CYP174A1 Halobacterium sp. NRC-1 (Euryarchaeota; Halobacteria)
AAG18971.1 GenPept, AE004437.1complement(326955..328172) genomic
1 MGPMETYVVT EPALVERLLV SDAAEFRKPE FQADAIDDLL GDGLLLSEGE SWREQRGRAN
61 PAFSMARVAG FDADIAAHAA DRVDDWPVGD TVDVEAAMTH ITLDVILDVM LGVSLPEARV
121 DAIGDALEPV GARFEPDPVR FAVPEWLPMP DDREYAAAVA TLDDLVDDIV AAREGTASGG
181 DGDDPMDLLS VLLRARDRGE QSLDRLRDEV MTTLLAGHDT TALTLTYTWF LLSEHPDVEA
241 RLHAELDGAL DDGAQPTVAQ LQDLDYLEWV LQESMRLYPP VYNVFRTPIE PVELAGSEVP
301 AGAPIMLPQW AIHRSPDHWD DPEAFDPERW RPERRADRPR FAYFPFGGGP RHCIGKQLAL
361 LEAKLIVATV ASDYRLRYEG DTPLSFVPSL TIHPEQEMRM RVEPR
CYP174A2 Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)
YP_134859, AAV45153 GenPept, NC_006396.1:56503..57840 genomic
62% to 174A1
1 MSKTPPGPKG EPLFGSSRTY ARDPFRFISA LERAYGDVAR FDMGPMDTVM LCDPTAIERV
61 LVSEADRFRK PDFQGDALGD LLGDGLLLSE GETWEQQRKL ANPAFSMARL SGMADRITGH
121 AEDRIADWSH GDVIDAEQSM TRVTLDVILD LMMGVELSEQ RVQTIEEQLL PLGQRFEPDP
181 IRFAMPQWMP MPDDAEFNRA VRTLDEVLDD IIEVREDSLG TDEDGPMDFL SVLLRARDDG
241 NQSPEQLRDE MMTMLLAGHD TTALTLTYTW FLLSEHPEVE QRVHEELDDV IGDDRPGMEH
301 VRELDYLEWV IQEAMRLYPP VYTIFREPTE DVTLSGYEVE AGTTLMVPQW GVHRSERFYD
361 DPETFDPERW KPERASERPR FAYFPFGGGP RHCIGKHLAM LEAQLITATT ASQYRLEFQG
421 ETPLELLPSL TAHPRQKMSM RVQER
CYP174A2 Haloarcula sp. LK1 (Euryarchaeota; Halobacteria)
GenEMBL HM135515
9 amino acid differences to CYP174A2 Haloarcula marismortui
probable ortholog
Lemoenkloof saltern, South Africa
CYP174A3 Halomicrobium mukohataei DSM 12286 (Archaea; Euryarchaeota)
ZP_03873471
72% to CYP174A2 Haloarcula marismortui
1 MAETPPGPKG EPLFGSSRTY AQDPFRFVEA LEDAYGGVAR FDMGPMDTLL IAEPELVQQI
61 LVDDDAKYRK PDFQDDALGD LLGDGLLLSE GDTWQEQRKL ANPAFSMARL ADMDDRIVDH
121 AESLVADWQD GSVVDAERGM THVTLDVILD LMMGVELPDE RVTTVQDQLV PLGARFEPDP
181 IRFAMPDWVP MPDDAEFDAA METLDGVLDD IFERRRGTTG DEDDGPMDFL SILMRARDRG
241 EQSDEQLRDE MMTMLLAGHD TTALTLTYTW FLLSEHPEVE QRLHEEIDAV VGDERPTIDH
301 VQELEFLDWV IDESMRMYPP VYTIFRTPTD PVELGGYDVA PSTNLMLPQW AVHHSERHWE
361 NPEEFDPERW SPERSEDRHR FAFFPFGGGP RHCIGKHLAL LEAKLIVATV AKDYRLRFEG
421 ETPLELVPSL TVHPRQEMSM RVEER
CYP174B1 Halorubrum lacusprofundi ATCC 49239 (Euryarchaeota; Halobacteria)
ZP_02017101.1, EDN48184.1 GenPept, NZ_ABEB01000009.1
complement(36125..37534) genomic
63% to YP_659381 Haloquadratum walsbyi, 53% to 174A1 with an insertion
1 MSATPPGPIG DPVFGNGRQY ADDPFSFMRA CADSYGDVVR FDLGPRETYM LTNPADVERV
61 LVADAERYRK PDFGDDAIDT LLGNGLLMSE GETWERQRRL ASPSFHSRRI GALAGTMVEH
121 TESQLADWAD GEVVDVQLEV ARLTVKIIVS AMFGADITDE EVKTVQEKLE PLGARFEPDP
181 RRFLIPNWMP TRENREFDAA IGTLESVIDG IVDRRRGTEY DPSVDPAGPG GVAVRGPVGD
241 GPDGDGAGDL PMDLLSVLLR ARDRGEQTDE NLRDELVTML LAGHDTTALA LTYTFYLLSN
301 HPEARERVAR EAAAATADGP PTAADAREMK FTERVLNESL RLYPPVYTLF REPKLDVKLG
361 GYRIPEGSAL MLSQWAIHRS PRWYDDPETF DPSRWEPERQ SKRPRFAFFP FGGGPRHCIG
421 KAFSLLEAKL ILAEVCSRYD LDYEGPDLSL RGSLTMHPDH PVPMRIRER
CYP174B2 Haloquadratum walsbyi DSM 16790 (Euryarchaeota; Halobacteria)
YP_659381 GenPept, NC_008212.1:3112950..3114311 genomic
CAJ53807 GenPept, AM180088.1:3112950..3114311
1 MSTQPPGPNG VPVFGNSRQY ASDPFTFLRS VADAYGDVVR FSLGPLDTYM LTNPVDIERV
61 LVTDDQKYQK PDFQDDAIGT LLGDGLLLSE GETWQKQRQL AQPAFGPKRI TSLAGTMTDH
121 TRGMLDGWEP GDIKDVHLEM ARVTVRIIVE AMFGTSLTDT QTTAVQENLE PLGKRFEPDP
181 LRFIIPDWVP TQENQEYHKS VSVLEDIIDE IVSERRGTET NSDIDPGAGS DDDPMDLLSI
241 LLRAKQRGEQ TDKQLRDEMM TILLAGHDTT ALTLTYTWYL LSEHPKVRDQ VHEELASVCG
301 GETPTMADTR SLDYTERVLQ ESMRMYPPVY VIFREPQVDV RLGGYRIPAG SAIMLPQWVV
361 HRSPRWYDNP TTFDPDRWRP ERRADRPRFS YFPFGGGPRH CIGKHLSMLE AKLILGTVAQ
421 SYELDYVRDR PFDLRGSLTM HPDEPMGMRV TER
CYP174B3 Halobaculum gomorrense (Euryarchaeota; Halobacteria)
GSS sequences BZ894476.1, BZ894445.1
54% TO 174A1, 60% TO 174B2, 66% TO 174B1
These two sequences do not overlap but they are
Most likely from the same gene
GRAGDLGRRRPHRRATGARAAHRPDHRHRDVGTDIDEETVRAVQENLEPLGQRFEPNPMR
AVIPNWAPTRENRRFDDAVATLEGVIDDLVARRRGTEETAPDPAGDAVDSPMPMDLLSIL
LRAHDRGDQTEGDLRDELMTMLLAGHDTTALALTYTFYLLSKHPEAKARFQREVDALDGT
PTAADLRDLSFTDRVLSEAXXXXXX
VYTLFRESKVDARVAGYRIPEGSLIMLPQWVVHRSDRWYDDPLAFDPDRWAPGRRADRPR
FAYFPFGAGPRHCIGKQFSLLEAKLILATVGRAFDLEYEGPELDLRGSLTMHPDHPMPLR
LSSR*
CYP174B4 Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
ZP_03998664, EEJ57769, ABTX01000001.1 1368411-1369736
76% to CYP174B2 Haloquadratum walsbyi DSM 16790 (Euryarchaeota;
Halobacteria)
1 MPLFGNSREY AKDPFTFLRQ VSEAYGDVVY FGLGPLDTYM LTNPADIERV LVSEDAKFHK
61 PDFQDDAIGT LLGDGLLLSE GETWRKQREL AQPSFDPRRI AALGETMTDH ATAMVEGWND
121 GEVRDVQLEM ARVTVKIIVD AMFGSSLADE RVRTVQENLE PLGKRFEPDP LRFLIPDWAP
181 TRENREYKQS ISILEGIIDD VVAERLGTEN DPSAAVAGED GAPMDLLSVL LRAKQRGEQT
241 DQQIRDEMMT MLLAGHDTTA LTLTYAFYLL SQHPESEAKV QAEVDKVCGG ETPTVADVRQ
301 FDYLERVLQE AMRLYPPVYV IFREPQVDVR LGGYRIPSGS AIMLPQWVVH RSPRWYDAPT
361 EFDPDRWRPE RRASRPRFSY FPFGGGPRHC IGKQFSMMEA KLILATVAQA YELDYVRDRP
421 FSLRGSLTMH PEEPMGMRLR AR
CYP174C1 Halomicrobium mukohataei DSM 12286 (Archaea; Euryarchaeota)
ZP_03874667
42% to CYP174A2, 41% to CYP197C1, 41% to CYP1002A1
1 MTTTDAPGPR GLPVIGNSHQ WARDPCAFRE RCAAEYGPVV NYEMLGWDTY MLTDPADVKR
61 VLEDPDTFPK HEPSNAQLEA FVGNGLLTSG GDLWERQREA IQPAFYMDHI RNYAERMVAQ
121 AAATADRWTA GESVDVRRAM TRCTLDILVD CLFGQEIDPA ERGLYEAVEA FQAPLEPSKQ
181 PITFFAPDWA PVPFLRRADR ALSHIDDQIY DIVETRRADE ADRDDLVAML IAADTAMDDE
241 QIRDELVTFL FAGHETTALS MTYVWDLLSR NPTAQRRLHE ELDALLDGRP TIEDVFDFEY
301 TGAVIEEAMR LYPPAHDIRR SPATTVEIGG YTIPEGSLVT LPTWVLHRDE RFWDDPEQFR
361 PGRFLDGGRS DRPEYAYFPF GGGPRRCIGQ QFAMTEAQLI LATIASEWTL EREYGDLELS
421 AAVTLQPSHD VAMTPHRRD
CYP175A1 Thermus thermophilus
GenEMBL AB001637 N-terminal 30 amino acids only 1587-1677
AX451783 full seq
Francesca Blasco francesca.blasco@po.uni-stuttgart.de
Full sequence submitted to nomenclature committee 9/17/2001
Crystal structure known
CYP175A1 Thermus sp. NMX2.A1
GenEMBL GU220073
6 amino acid differences to CYP175A1 Thermus thermophilus
probable ortholog from Jemez Springs, New Mexico
CYP176A1 Citrabacter braakii
GenEMBL AF456128
David Hawkes and James De Voss, University of Queensland, Australia
Full sequence submitted to nomenclature committee 11/15/2001
P450cin involved the hydroxylation of cineole
CYP177A1 Rhodococcus rhodochrous strain 11Y
GenEMBL AF449421
Seth-Smith,H.M., Rosser,S.J., Basran,A., Travis,E.R., Dabbs,E.R.,
Nicklin,S. and Bruce,N.C.
Cloning, Sequencing, and Characterization of the
Hexahydro-1,3,5-Trinitro-1,3,5-Triazine Degradation Gene Cluster
from Rhodococcus rhodochrous
Appl. Environ. Microbiol. 68 (10), 4764-4771 (2002)
submitted to nomenclature committee 7/30/2002
degrades an explosive to confer RDX degrading phenotype
alternative name XplA (for explosive gene A)
CYP178A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV838
CYP179A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2061
CYP179A2 Streptomyces scabies
SCAB19191
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
74% to 179A1 with insertion Streptomyces avermitilis
CYP180A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2165
CYP180A2 Saccharopolyspora erythraea NRRL23338
SACE_3525, se: 3884312,3885574 (-) STRAND,
61% to CYP180A1
VTATGVPDVFDPRRYSSGIPHADFAWLRANAPVSWQPEHAVGDWPAGPGFWAVTGYDDVV
RVLRSPGEFSSWLGATQIRDPAPADLPFIRRMMLNLDPPEHGKLRRIVSRAFTPRRVERF
RAEVAARARRLVDAVAERGGCDVPPDLTDDFPLLNLADLMGVPEADRRMLLEWTNRIIGY
QDPEHSEVVRDADGRPLNPRSPAMLADMFGYAQELAAHKRRHPADDLMTALATAEVDGGR
LSGAELEMFFFLLSVAGNDTVRSALPGGLRAFAEHPGQHRLLLESPELLDRAIEETLRYH
PPVLSFRRTATTDVELAGQAIPVGAKVVVFHCSANFDPARFDDPLRFDIRRDPNEQLSFG
TGPHVCLGAHFARLQLRAFYSEALWRLRDLHVTGPVRHLVSNFINGIKHLPVAFTAVRPR
CYP180A3 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_2082
51% to CYP180A2 Saccharopolyspora erythraea NRRL23338
54% without 21 aa insertion
missing about 5 amino acids at N-term
CYP180B1 Streptomyces scabies
SCAB9651
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
41% TO 180A1 Streptomyces avermitilis,
40% to CYP125A2 Streptomyces avermitilis NOTE: CYP180 AND CYP125 ARE
QUITE CLOSE AND MAY BE LIKE SUBFAMILIES OF A SINGLE FAMILY.
CYP181A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2385
CYP182A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2806
CYP182B1 Streptomyces scabies
SCAB81761
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
47% to 182A1 Streptomyces avermitilis
CYP182C1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2935 48% to CYP182B1
CYP183A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV2999
CYP183A2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_10598
72% to CYP183A1 Streptomyces avermitilis
CYP183B1 Mycobacterium marinum
No accession number
Tim Stinear
MM0281
45% to 183A1
CYP183C1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7103
43% to CYP183B1 Mycobacterium marinum MM0281
CYP183D1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7104
44% to CYP183A1 Streptomyces avermitilis
CYP183E1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7185
43% to CYP183B1 Mycobacterium marinum MM0281
CYP184A1 Streptomyces avermitilis
No accession number
Submitted by David Lamb and Haruo Ikeda 9/3/02
Clone name SAV5111
CYP184A2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_734
65% to CYP184A1 Streptomyces avermitilis
CYP185A1 Mycobacterium smegmatis
MSMEG0814 TIGR
59% to CYP185A5 Mycobacterium vanbaalenii
57% to CYP185A3 Mycobacterium avium subsp. paratuberculosis
52% to CYP185A2, 57% to 185A4, 66% to 185A5, 54% to 185A6
MRADTRFMVETASPPLTELPLAPRNTLPCREQIRCLRSFIDGMQRLRDVGGPVTRIV
LGPRWLVPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQLQRLMGGNLL
DLPHDRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWADGATVDLD
RACRALTLRALGRSVFGVDLDQRAEDVGPALRTSLSWVADRASRPVNLPQ
WVPTRGQRKARAGNATLHRLAAEILADVRADPDRDAPLVRALLEARDPET
GRGLTDDQICDELVLFMLAGHDTTSTTLCYSLWALGHHPDIQERVYAEVA
ALGDRELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMTVDGYRV
EAGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAGRNRWQYLPFGGG
PRSCIGDHFAMLEATLALATVIRAVSVESQNTDLPVETPFTVIAAAPVPA
RVTRR
CYP185A2 Mycobacterium smegmatis
MSMEG0958 TIGR
52% to CYP185A1
71% to 185A6, 59% to 185A5, 57% to 185A3, 53% to 185A4
MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVRAL
DMGQQVIRAAGGAVTRVQFGPRWLVPPLVAVFSPEGIRDVLGRNDAFAER
CIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTKHSVRAFGGHMSRAA
QTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGRSVLGIDLNERADVIV
EHMHVASSYATDRALRPLRAPRWLPTPARRRARAAVAAMRAVTAEILQAC
RDDADRDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATAL
TYALWALGHHPEIQDRVAAEARALGDRELTPADVPQLGYTVQVLHESLRM
CPPAAGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPDPEVFDP
DRFSPENSRERDRWHFIPFAGGARACIGEHFARLETTLALATIIRSVVVG
SVDAEFPVDVPFTTVAKGPIRANVAPRGPDHYTL
CYP185A3 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017231.1
CDS 236434..237804
Name changed from CYP277A1
MSVAEPKRDIAGLPLAPKNPLSYRERLRAIKEFHTGTNKLRDAG
GPVTRVTLGPRWLISPIVLATSPQGIRDIVSVRDGSIDKTSTVATELRRLLGPNLFVL
PHTEWLPRRRTLQPVFTRQRVREFGGHMAEAAESVCAGWPEDTEIDLDAQCRTLTLRA
LGRSVLGLDLDERSDAIAEPLRVATSYAVRRALRPLRAPEWLPTPSRRRARAAAGAIR
ALADEILQACRADPGREAPLVHALIAATDPETGQALSDKEIRDEMIIFLFAGHDTTAT
TLTYALWALGRHPEYQARVAAEVAELPDRHLTPDDVARLGFTVRVLQEALRLCPPGPT
GTRMATRDVEVAGYRVEAGTMLAFGRMAVQTDPSLWDAPLRFDPDRFDPRRAGDRDRW
QYLPFGGGPRSCIGDHFAMLEATLALATIVRRVEIESLSDDFPLAVPFTMVAAAPIRA
MVRRRR
CYP185A4 Mycobacterium marinum
No accession number
Tim Stinear
MM0852
58% to CYP277A1 Mycobacterium avium subsp. Paratuberculosis
35% to 184A1
Name changed from CYP277A2
CYP185A4 Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 277A1 M. marinum = ortholog
Name changed from CYP277A2
CYP185A5 Mycobacterium vanbaalenii PYR-1
ZP_01204630.1, EAS25622.1
59% to Msmeg_CYP185A1
MVGTVEREDLGALPLAPRNPLPYRQQVRAIRTFHTGLETLRDAGGPVTRLKLAPKWLMPPMVVATSPQGA RDILARGGGHIDKTRVHHEMRRLLGANLFDLTHEPWLPRRRALQPIFTKQHVREFAGHMATAAQTVADSW ADGTELDLDTECRKLTLRALGRSVLGLDLDEHSDAIAEPLRTALEYIADRALQPISAPRWLPTPARRRAR AASSTLHKLADKILQACRTDPTRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYA MWALGHHHDVQDRVRAEVVGIGDRELTPEDVPALGYTIQVLHEALRLCPPAAATARMAMRDVEVDGYRIE AGSMMAVGIYALHRDPALWERPLVFDPDRFSAQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLALATI IRSAEIRSSDPHFPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR
CYP185A6 Mycobacterium vanbaalenii PYR-1
ZP_01204233.1, EAS25225.1
71% to CYP185A2
54% to 185A4
MTARDTAAAPEVGSLPLVPRNPLPLWKLVQLVRRLDTGQEVIRDAGGPITRIQLGPKKLMPPIVAVMSPA GMRDVLGRNDASSDRCIIHEQVQEMAGDSLWVLPNEQWRPRKRALAPVFTKTSVRAFGGHMSKAAQAFVD RWPSGGEVDLDAECRRVAMQSLGRSVLGVDLNERGETIARCMHVASSYTADRALRPVRAPRWLLTPARQR ARSAVNAMRAITDEMVKACRDDPTRDAPLVQALIAATDPETGRPLTDEEISNDLLIFMLAGHDTTATALT HALWVLGHHPDIQDRVAAEAAAIGDRELTPDDVPALGYTVQVLHESVRLCPPAAGVARLVTRDFAVDGYR VEAGSLVALGLYALHHDPALWPDPMAFDPDRFSPENVKARDRWQFLPFLGGGRPCIGEHFARLETTLALA
TVVRACRIESLDDLFECEVPLTTVAKGPIRARVTPRR
CYP185B1 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
51% to CYP185A5 Mycobacterium vanbaalenii PYR-1
CYP186A1 Mycobacterium smegmatis
MSMEG1773 TIGR
65% to CYP186A2
MSDGGHQLRGAQALATLVDLGFPAIASGVIARRPPVLGLLERMQADERAGRR
MHRLRSEFGRGPVELVIPGRRIVVVTDPEDVAAVLVQAPEPFHPANRE
KRKALQWFQPHGVLISQGPIREQRRTVNEAALDSGAAMHRLAESFAAKVA
AEADTLVARTLPGQRLDADEFMTAWWRLVRRLTLGERARDDHAITDQLAR
LRRAGNWSFLSLPHYRARSRFLSHLYRYAEDPEPGTLVGALADVPAGGAV
DPVGQIPQWLFAFDAAGMALLRALAVLATHPLQRDRALEDAGEPNRPLLR
PYLRGCLLESVRLWPTTPAILRDTTEDTHWREGAERFTVAKGAGLLIVAP
AFHRDDQVLPFAHDFVPEIWIDGRAQLYPQLVPFSAGPAECPGRNLVLFT
TSTLAANLLNRLHFDVRSEPRPVPGEPLPMTFNHAGIEFSLRPARRAVTA
ATVDPAT
CYP186A2 Mycobacterium sp. JLS
ZP_01278281
65% to MSMEG1773 CYP186A1
MGASGRRLTG ARAAATLADL GPASTAARAV RRMQQLREQF GAGPVELVLP GRRMVVVLDP
DDVRRVLAGA PEPFHPANRE ERKSLEWSQR RDLDDAALDS GAEMHRLAGA FGDVIAAEAR
ELTDEVTARG TMDANQFMAA WWRIVRRIAL GDRARDDDEI TDALLRLRRA RNWSFLSMPH
YRTRARFLER LYDYVEDPQI GTLAAAVPAS GAVDPVGPLP QWLFAFDAAG IAQLRALAVL
ATHPAAMARA IEDAAEPDRL RLRPFLRACV LESVRLWPTT PTILRETTEK GAGLMIVTPA
FHRDPKLLPF ANDFVPDIWL DGRARSYPQL VPFSAGPAEC PGRNLALFTT STLLANLLSA
LDFRISSMPH LSPDEPLPVT LNQHGLEFAV VTAPRWRHHR AGSAVRS
CYP186A3 Nocardia farcinica
AP006618.1, YP_120573.1
65% to MSMEG1773 CYP186A1
4523238 MSGRHPETVARDQDERSPAPVPTS
4523166 AEHGRRLDGTRAVAALTDLGFAAIAAGVIARRRPVMGLLEKAQADSRALQRMRQLRREFG 4522987
4522986 AGPVELVVPGRRIVVLLDPGDVGRVLAEAPTPFHPANREKRAALRQFQPHGVLLSKGVVR 4522807
4522806 EQRRAVNEAVLDTDAPLHRLAEPFAAIIADEAAQLMASALQRGHLDAEHFTIQWWRMVRR 4522627
4522626 LVLGERGRDDSAITDELWRLRSAANWSFLAPPHRRRREVFTEQLYRYVERPDPNSLAGAV 4522447
4522446 AAVQTGGAVDPVGQIPHWLFAFDAAGMAAQRALAVLATHPDQQAAATADAADPHQVHLRP 4522267
4522266 YLRACVLESVRLWPTTSTILRDITEPTQWRAGADAFTIAPGAALLILVPAFHRDADLLPF 4522087
4522086 ADRFAPEIWLDGQAAQYPQLVPFSAGPAECPGRNLVLFTTSTLLAHLLAAAEFRLRSGHR 4521907
4521906 MSPQTPLPLTLNNFGLDFDVTRLPNVAS* 4521820
CYP186B1 Saccharopolyspora erythraea NRRL23338
SACE_2090, se: 2276121,2277467 (+) STRAND
49% to CYP186A3 AP006618.1 Nocardia farcinica = YP_120573.1
MTPKVSAALTTGVRTASPTDTARVAAQVVLPALATGVISRRPRVMALAERLRADRRAVGL
LRELRSRYGAGPLRLRVPGRDVVLVLSPEHVRRVLVSDAESFTPANREKQAALGHFQPHG
VLLSRGLDRARRRQFHEHVLETREHAHHLAPRFIQVVREEARVLLDEAERTGSLDWQTFG
AGWWRVVRRIVLGDQARDDRELTGELDALRSDANWAFLSPKRLSLRRDLRARLREHLRRA
EPGSLAETVARAETPVQAPEEQVPHWLFAFDAAGMAAFRALALLAAQPEQAARARSEIAE
SDLATPQPLHHLRACVLDALRLWPTTPMLLRDSVEETAWDGRQLPAGTAFLVFAPLFHRD
ETAADFAHAFTPEAWLDGRAEHHSALVPFSAGPGRCPGENLVLLVTSTLLAVLMRDAEFE
PGEGPALGPQGPLPATFDNFHTTVRLAR
CYP186C1 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
50% to CYP186A3 Nocardia farcinica
CYP187A1 Mycobacterium smegmatis
MSMEG2245 TIGR
35% to 159A2
78% to CYP187A6 Mycobacterium vanbaalenii
77% to CYP187A2 Mycobacterium avium subsp. paratuberculosis
MDSRIRDDPAVDTAALLRDPYPIFARYRAQAGVFRGSVMDWSKTPKELMP
EHQYAAMSFDAVNTVFRDGKTFNSKIYDSTIGLFIGPSILAMEGKTHRDH
RNLVSAAFKSKSLARWEPEIARPICEALVDEFVDTGSADLVRDYTFEFPT
RVISKLLGLPEEDLPWFRRRAVELISYSVKYKRAFEASAALKDYFLDQIE
RRRSRPTEDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGN
LLYLLLTHPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELE
GVQIPAGAVIDVCIGSANRDENRWERPEEFDIFRKRIPHITFAAGEHTCM
GLHLARMETRVAMETLLNRVTDLRLIADDDPHIFGQPFRSPTAIPVTFRPAG
CYP187A2 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017235.1
CDS 255472..256674
Formerly CYP273A1
MMTNVPTAAGDETVSLRDPYPFFARKRREAGVFAGTVMDYSKTP
ESLMPKQEYSAVSFDAVNTVFRDGRVFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNL
VSAAFKSKALARWEPTIVRPICNALIDDFIDAGTADLVRQFTFEFPTRVIARLLGLPD
EDLPMFHTRAVQLISYHVDYERAFEASAALKDYFLEQIEQRKSKPTEDIIGDLVTAEI
DGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPDQFAALQADRELLAPAIE
EGLRFETPLTTVQRFTTEDTELQGVRIPARSVIGVCIGSANRDERRWERSEEFDIFRK
HVPHISFAAGEHTCLGLHLARLETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTA
LPVTFDAK
CYP187A3 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017235.1
CDS 236687-237919
MPLSTGPTGQPVVPTLDFTGETSPYPFFEHMRRTDPVWHGSLAD
ASQLPEELRPEDEWVLFDYESVSQAFRDDRIFSSHKYDETIGLVMGHTILAMGGREHH
DHRNLVAKAFRATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTL
LGLPAEDLDLFRRLSLDLISIPTDIEAGLNAATELYDYFLKQVEQRRRKPTDDIIGDL
VAAEIDGEKLTDEAIIAFLRLLLPGGLETTYRSSGNLLYLLLTHPEQLAMVYRDRSLI
PMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAF
DIRRPRQAHIAFAGGIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIV
GLTFRSPNKLPVTFAPAA
CYP187A4 Mycobacterium marinum
No accession number
Tim Stinear
MM3996
85% to CYP187A2 Mycobacterium avium subsp. Paratuberculosis
57% to CYP187A3 Mycobacterium avium subsp. Paratuberculosis
38% to 159A1, 38% to 159A2, 57% to 187A5
CYP187A4 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 187A4 M. marinum = ortholog
CYP187A5 Mycobacterium marinum
No accession number
Tim Stinear
MM4008
82% to CYP273A1 Mycobacterium avium subsp. Paratuberculosis
56% to CYP273A2 Mycobacterium avium subsp. Paratuberculosis
36% to 159A2, 57% to 187A4
CYP187A5 Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 187A5 M. marinum = ortholog
CYP187A6 Mycobacterium vanbaalenii PYR-1
ZP_01203863.1, EAS24855.1
78% to 187A1, 35% to 159A2
MDQRPGRARRFGVRHVDDGGHSDRAVARRCTGKYCKRYSNEMETPVQDLAKDEPIDLRDPYPMFARRRAE GGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGKVFNSHIYDSTIGLFIGPTILAMEGKTHWEH RNLVSAAFKTRSLARWEPEIVRPVVNELIDEFIDDGRADLVRDFTFEFPTRVISRLLGLPEEDLPWFRKR AVELISYAVNYKKAFEASAALKDYFLGQIDKRRSAPTEDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAG LETTFRSSGNLLYLLLTHRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPAGSVI DVCIGSANRDESRWERAEQFDIFRTRTPHISFAAGEHTCMGLHLARMETRVAAETLLSRLSAIELLTDGD PHIHGQPFRSPTALPVTFTPSRARP
CYP188A1 Mycobacterium smegmatis
MSMEG4791 TIGR
87% to CYP188A4 Mycobacterium vanbaalenii
65% to CYP188A5 Mycobacterium vanbaalenii
72% to 188A3
MSIQDVTTDDDREKITYHFDRHTPEYRLQFEKITEEMHSRCPVAWTETYD
GHWVAAGSNEVFELARCPVVSNHHDISGETPFQGITIPKASRATVVRGGI
LEMDEPEHSAYRGALNPYLSPAAIKRWEPFVDEITRAAIDEHISSGRIDF
VEHLANVVPAVFTLAMMGIELKKWNVYSEPTHASVYTPEHAPEREKINEQ
HREMGIDLINNMMEIRQNPRPGLVNALLQL
RIDGEPAPDMEILGNLGLII
GGGFDTTTALTAHALEWLGEHPDERERLSRERDTLLNPATEEFLRFFTPA
PGDGRTFAEDAEVAGYKFKQYERLWLSWAMANRDPSVFDKPNEVILDRKG
NRHFSFGIGVHRCVGSNVARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTI
GVIQGMRNLPATFTPSRPLGPGLDETLEKLQRICNEEELARPITERKERA
VID
CYP188A2 Mycobacterium avium subsp. Paratuberculosis
AE017229.1 CDS complement(173813..175057)
MPDAWTDTYGGHRVAAGSHEVFELARCPAVSNDHDINGERRGYK
GISIPTASRVSAVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWEPFIDEVTRAALDE
KIEEGSIDFVDDLANIVPAVLTLAMLGIPLKKWKMYSEPVHAAVYTPEHSPDIERVTA
MHREMGLDMVNNMLEIRENPRPGIVNALLQMRIDGEPAPDLEILGNLGLVIGGGFDTT
TALTAHSLEWLSEHPEQRQLLSDERKTLLDPATEEFLRYFTPAPGDGRTFSEDFELDG
TVFKEGERLWISWAMANRDPAVFHDPDEVILDRKGNRHFSFGLGIHRCIGSNVARTVF
KSMLIAVLDRMPDYRCDPEGTVHYETIGVIQGMRKLPATFTPGRRIGAGLDETLEKLQ
RICDEQELARPITERKEAAVID
CYP188A3 Mycobacterium marinum
Tim Stinear
MM4717
86% to CYP188A2 35% to CYP222A1 Thermobifida fusca
CYP188A3 Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 188A3 M. marinum
36% to CYP243A1 Mycobacterium avium
formerly 281A2
CYP188A4 Mycobacterium vanbaalenii PYR-1
ZP_01205759.1, EAS26751.1
74% to 188A3
MSVDDVVSGTADDSRKQNRYYFDRHTPEYRLQFEKITEEMQTKCPMAWSDTYGGHWVAADSKHVFELARC PVVSNHHDISGETPFQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWEPFIHEITRA ALDEHIESGRIDFVDHLANVVPAVFTLAMMGIKLDKWNVYSEPTHASVYTPEHAPEREKINEQHRAMGLD LITNMMEIRENPRPGLVNALLQLRIDGEPAPDIEILGNLGLIIGGGFDTTTALTAHALEWLGEHPDQRQR LSSERATLLDPATEEFLRFFTPAPGDGRTFADDVEVEGQRFKKFERLWLSWAMANRDASVFDRPNEVVLD RKGNRHFSFGIGVHRCVGSNVARTLFKSMVTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPGK
RLGPGLDETLEKLQRICDEQELARPITERKEAAVID
CYP188A5 Mycobacterium vanbaalenii PYR-1
ZP_01203997.1, EAS24989.1
68% to 188A3
MADQLDRRREARSFHFDRHTPQYRDRFQEITAQMQARCPLAWTDTYGGHWVAAGNREVFELARCPHVSND NDIDGTRRGYTGINIPRGDYSVAFRGGMLEMDDPEHREYRSPLNGYLSPAAVRRWVPVVDELVKACLDEK IEDGRIDFVDDLANIVPAVLTLGLLGVPLKDWEIYCEPAHASVYTPADSPDFPRVADLAIASAMGMMHHV AEIRQTPRPGLIDALVRTRIDGQPAPDTEIMGMLMLLIGGGFDTTTALTAHALEWLSQHPDERERLSRDR DTLLDPATEEFLRYFTPAPGDGRTVAEDIEVDGVVLKEGERLWLSWAMANRDPALFQNPDEVVLDRKGNR HFSFGLGVHRCIGSNVARTVFKSMLTAVLDRMPDFQCDAAGAVHYETIGVIQGMQHLPAAFTPGPRLGPG
LEATLEKLQRVCDEQQLAAPITVHKAAAVI
CYP189A1 Mycobacterium smegmatis
MSMEG4818 TIGR
64% to 189A2, 52% to 189A3 52% to 189A4
64% to 189A7
82% to 189A9 Mycobacterium vanbaalenii
53% to 189A8 Mycobacterium vanbaalenii
MPPFDDGVPMAQPSTSATPDLYYDPYSVQLNMEPHEVFARIREEAPLYYN
EQHDFYALSRYHDVNKAVIDHETFISGRGALLELIKSGMEIPPGTLIFED
PPIHNIHRNLLSRMFTPRKVLALEPQIREFTTRCLDAVAGSDTFDFVNDL
GEQMPMRVIGMLLGIPEDRQRAITDHGEETLQGTTVDSLATGEVFAEFID
WRADNPSDDIMTDLLNAEFEDETGTVRKLRRDELLLYLTVIATAGSETTT
RALGWAGKTLADHPDQRRDLVENPALIPQAIEELLRWEPPALQIARYVTR
DVEYYGKTVPAGSAMLMLVGAANRDHRRFPPNGDVFDIHREQFSHMTFGA
GTHFCMGNALARLELRVALEEILKRFPEWEVDWDNARPSETAAVRGWAAM
PTFVR
CYP189A2 Mycobacterium smegmatis
MSMEG4873 TIGR
64% to 189A1, 59% to 189A3, 55% to 189A4
72% to 189A7
61% to 189A9 Mycobacterium vanbaalenii
58% to 189A8 Mycobacterium vanbaalenii
MTASATQNVYFDPYDVAINADPYPTFARLREEAPLYYNEQFDFYALSRFS
DVNKALIDHETFSSARGAIVELIKADIEIPSGALIFEDPPIHTAHRKLLS
RMFTPRKINALEPEIRRFCAQSLDAVAGVERFDIIKDFGAIMPMRVISAL
LGIPEEDQEKIRDHGNAQMRTEAGKPMKAAEEGLVDGSIFEAYIDWRKDN
PSDDIMTELLNVEFTDEHGVTRNLTREELLIYINVVAGAGNETTTRLIGW
AAKTLAEHPDQRRQLVENPALIPQAIEEILRFEPPAPHVARYVTRDVEYH
GRTVPEGSVMMLLIGAAVRDSRQFPPDGEVFDINRAPRQHLAFSVGTHFC
LGSALARLEGRVALEEILKRFPEWDVDLASAELSPTSTVRGWDSLPVIVR
CYP189A3 Mycobacterium smegmatis
MSMEG3700 TIGR
59% to 189A2, 57% to 189A4 52% to 189A1
86% to 189A8 Mycobacterium vanbaalenii
50% to 189A9 Mycobacterium vanbaalenii
83% to 189A6
MTVDDSGVVVTGVAGPYYDPYDVGIVADPYPVYARLRDEAPLYHNERYGF
WALSRHADVESALANWETFSNSRSDILELVKSDFDMPPGVMMFTDPPMHT
MLRGLMSRVFTPRRMAEIEDQIRRYCVRCLDPLVGSDRFDIIAELASTMP
MRVIGMLLGIPESEQIGVRDANDANLRTKPGAPMKVAQADKIADGRIYAD
YVEWRSKNPSDDLMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNE
TTGRLIGWLAKVLAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARW
VARDFEAYGQTVPAGSAMLLLFGAANRDPRRYTDPDVFDIHRDNISHLTF
GKGLHYCLGANLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWE
RLDVLVG
CYP189A4 Mycobacterium smegmatis
MSMEG6584 TIGR
57% to 189A3, 55% to 189A2, 40% to CYP123
58% to 189A8 Mycobacterium vanbaalenii
53% to 189A9 Mycobacterium vanbaalenii
57% to 189A7
MRVLDELSYDPYDVEIDVDPYPTYRRLRDEAPVYFNGRFGFWALSRFADV
EAALRDVDNLSNAKGDILEVVKAEPKMPLGVFINEDPPLHTVHRLLVSRA
FTPRKMRAIEDQIRTFCAACLDPLTSGDRFDFTLDLGAEMPMRVIGMLIG
IPEELQRSVRKVAGQRLRNKPGEPLPVNKDNYFNGNMFRDYVEWRAQNPS
DDLVTELLNVEFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLG
KLLGEHPDQRRALVADPSLIPGAVEEVLRYEPPVHNIARYVSADVDYHGQ
TIPAGSALLLMTGAANRDERRFDDPDRFDIRRSPNHLSFGRGAHFCLGAS
LARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG
CYP189A5 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017234.1
CDS complement(151992..153206)
MVMTGTSAIELYYDPFDSGIDDNPYPVWQRMREEAPLYYNEKYN
FYALSRYEDVARELPNWQTYRSGRGTTADILFSNVEVPPGILLFEDPPLHDLHRRLLS
RVFTPRRMLAVEDLVRGFCVRELDPLVGAGGFDFIRDLGAMMPMRTIGYLLGIPEEDQ
EKIRDRSVANIELSRDSDPAAVDANVFANSIALFADYIEWRADHPSDDLMTELLRAEI
DEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQLLSDHPDQRRELAADPSLI
PGAVEETLRFEPPSPVQARYVARDAEHYGRVVPEGSFMLLLNGSANRDPRRFTDPDRY
DIHRQGGGHLSFGQGLHFCLGSALARMEARVAFEEVLKRWPDWEVDYANAERARTASV
RGWARLPVVTGG
CYP189A6 Mycobacterium marinum
No accession number
Tim Stinear
MM0928
57% to 189A7
52% to 189A5 Mycobacterium avium subsp. Paratuberculosis
37% to 123A1
CYP189A6P Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 189A6 M. marinum in conserved region = ortholog
CYP189A7 Mycobacterium marinum
No accession number
Tim Stinear
MM4753
57% to CYP189A6
54% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
37% to 123A1
CYP189A7 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 189A7 M. marinum = ortholog
CYP189A8 Mycobacterium vanbaalenii PYR-1
ZP_01203775.1, EAS24767.1
82% to 189A6, this seq is short at N-term
MADDLYYDPYDQGIVADPYPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILELIK SDFDMPKGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRRYCVNCLDPLVGSDGFDVIAELAAMMPM RVIGMLLGIPESEQVSVRDANDANLRTRPGAPMKVADPDRIADGRIYSDYVEWRAANPSDDLMTALLNVE FTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKVLAEHPQQRREIVEDRSLLGRAVDETLRFE PTGPHVARYLARDFEYDGTTVPAGSAILLLFGAANRDERRYRNPDTFDIHRDNISHLTFGKGLHYCLGAN LARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG
CYP189A9 Mycobacterium vanbaalenii PYR-1
ZP_01205817.1, EAS26809.1
35% to 123A1, 82% to 189A1, 66% to 189A6
MTISADDSDVQNADTAAELYYDPYNVDLNMDPHGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQ TFISGRGALLEIIKSGMEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIREFTARCLDPLTGTN RFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDHGEATLQSDSVDLMATGEVFAEFIDHRTEHPSDDIMT DLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKTLADYPEQRAQLVADPALIPQAIE EILRWEPPALQIARYVTRDVEYYGQVVPEGSAMLMLVGSANRDHRRFPPNGDVFDIHRELRSHMTFGAGT HFCMGNALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS
CYP189A10 Frankia sp. EAN1pec
YP_001507240.1
ABW12334.1
61% to CYP189A7 Mycobacterium marinum
MSLLRSKDIYYDPYDAQIDSDPYPVWRSMRNEEPLYYNEKYDFYALSRYGDVDACLSDRATYRSGRGSIL
EIIKANIEFPPGMILFEDPPIHDVHRGILARIFTPKKMNALESKVREFCVRSLDPLVGSGRFDFVEDLGA
QMPMRTIGFLLGIPEKDQEAIRDHSNAGQRLDEGQEPTVREPNGEHFEAYIDWRAEHPSDDLMTELLHAE
FDDETGTRRRLSRSEVLLYIQMLAGAGNETTTRLIGWTGKVLGEHPDQRREIAADRSLIPQAIEELLRYE
APSPVQARYVARDVEHYGRTIPENSAILLLNGSANRDERQFPDGDRFDIHRRRSRHLSFGYGIHFCLGAA
LARLEGRVALDEVLKRFPDWEIDRDSAIQARTSTVRGWQSLPVFVP
CYP189A11 Frankia sp. EAN1pec
YP_001508161.1
ABW13255.1
59% to CYP189A7 Mycobacterium marinum
MTTVTTETSDAAGDVYYDPYDFEIDADPYPVWRRMRDSVPLYYNAKYDFFAISRFDDVEKVMGDFETYRS
GRGSVLEIIRSNIDFPPGNILFEDPPVHDIHRSILARVFTPRKMLAIEPKVREFCARSLDSLVAEGNFDF
IADLGAQMPMRTIGMLLGIPEQDQEAIRDAVDEGLTLTEGAPKPLNEDPLARSEGMFADYLDWRARNPSD
DLMTELITAEFEDETGTTRRLTRAEVLTYVNMLSSAGNETTTRLIGWTGKVLSDHPDQLRQVARDRSMVN
QVIEEVLRFEAPSPVQARYVARDVEVHGQTVPEGSVMVLLNGSANRDERQFVNGDSFDIHRSISRHVSFG
RGLHFCLGAALARLEGRVALDEVLKRWDRWEVDYDRAVQARTSTVRGWAKLPVTATPR
CYP189A12 Frankia sp. EAN1pec
YP_001508322.1
ABW13416.1
64% to CYP189A7 Mycobacterium marinum
MPLTSPSDVYYDPYDAQIDADPYPVWRRMRDEASLYYNEKYDFYALSRFEDVEPCLSDWNTYRSGRGSIL
ELIKANIELPSGIILFEDPPIHDIHRSLLARVFTPRKMNALEPKIREFCARSLDPLVGTERFDFIRDLGA
QMPMRTIGFLLGIPESDQEAIRDRLDEGLQLREGEELSVSAEDFNADEFGAYIDWRAEHPSDDLMTELLN
AEFEDETGTVRKLHREEVLTYVTMLAGAGNETTTRLIGWTGKILAENPDQRRELVADRSLIPNAIEELLR
FEAPSPVQARYVARDVEHHGHTVPEGSIMVLLNGSANRDERRFADPDRFDVHRDVGRHLSFGYGIHHCLG
AALARLEGRVALDEVLSRFPTWEIDWDNAVQARTSTVRGWETMPAFVR
CYP189A13 Frankia sp. EAN1pec
YP_001509005.1
ABW14099.1
62% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MSLASHLGDVYYDPYDFRIDADPYPVWRRMRDEAPIYYNEKYEFYALSRFEDVERALSEWGTFLSGRGTL
LEIIKANVPIPSGNILFEDPPVHHAHRGVMARVFTPKKMNAVESKVREFCGRALDPFIGTDGFDFIGDLG
THMAMRTIGYLLGIPEEDQEAIRSLFDDNLRIEDPDNPRPPDIGIDGAFVDYIEWRAEHPSDDLMTELMN
AEFEDETGTVRTLTRDEVIAYINLLAGAGNETTARLVGWVGKLLGEHADQRRELAADRSLIPNAVEEVLR
YEAPSPVQARYIEREVELHGRTIPAGSVVLLLNGSANRDERRFPDPDRFDIHRSVGRHLGFGYGIHHCLG
AALARLEGRVALDEVLQRFPDWEVDWDNAVQARTSTVRGWEKMPVRIG
CYP189A14 Frankia sp. EAN1pec
YP_001509058.1
ABW14152.1
58% to CYP189A7 Mycobacterium marinum
MSRSGPVYWDPFDRDIAGDPYPVYQRLRAEAPLYYNDRQDFYALSRHEDIDRCLTDWKTFSSARGPILEI
IKANVEIPPGTLLMEDPPAHDIHRALLARVFTPRRVTSLEPQVRDFCRRCLDRLVDVDSFDLMAEFANEV
PMRVIGMLLGIPESDQPAIRERADAKLRTEPGQQMKVSQQALMDSDLFAEYIDWRAEHPSDDLMTELLRA
EFEETLRFEPTGHAIARYVTTGVELHGRTVPAGSAMMLLIASANRDENSWSDPDRFDVHRGTGHLRTFGL
GTHYCLGAALARLEARVALEEILKRFPRWNVDWENSALSSTSTMRGWETLPITVG
CYP189A15 Frankia sp. EAN1pec
YP_001510639.1
ABW15733.1
61% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MQDESVYYDPYDFEIDANPYPVWRRLRDSAPLYYNEKYDFYALSRFEDVEKALTDFGTYTSGKGFILEVI
KAGIRLPPGNLLAEDPPLHDIHRGLLSRVFTPRKMAALEPQVRELCARILDELVGTDGFDFVADLGAIVP
MRVIGMMLGIPESDQVAIRDAGTRRHQLTEGEAPAPTDARSTAQPFADYIDWRATHPSDDLMTELLRAEF
EDETGTTRRLTRDEVLTYTSVLAGAGNETTRRLIGWTGQLLGEHPDQCRELAADHSNVPQAIEEILRFES
PSPVQGRVVSRDVEHHGGTIPGTIPEGSAVILLNASANRDERHFADPDTFDIHRRIDRHLAFGHGLHFCL
GASLARMEGRVVLDEVLKRWSSWEVDRDNSVLDHTSTTRGWMNLPVVTS
CYP189A16 Frankia sp. EAN1pec
YP_001511333.1
ABW16427.1
70% to CYP189A4 Mycobacterium smegmatis
MTQDDLYYDPYDVEIDVDPYPTYRRLRDEEPLYYNERLDFWGLSRFADVGAALKDQKRLSSAKGDILEVI
KADPVMPPGVFINEDPPLHTVHRVLVSRAFTPKKMKALEDKIRAFCIACLEPLEGADRFDFVADLGDELP
MRAIGMLVGIPDAEQPTVRDHAQRGLRNERGKPLTVTKDKYFDGDFYADYVAWREKNPSDDLITELLNVE
FEDVSGTTRRLTKEEILIFLAVIAGAGVETTGNLFGWLGKVLAEHPDQRQQIVSDRSLIPNAIEELLRYE
PPGPHVARYVTEDVEYHGQTVPAGSALLLMLSSANRDERQFTDPGRFDIHRSISQHVTFGIGAHFCLGAA
LARMEGRIALDEVLNRFPEWDLDMANARRKPTTTVRGWDSMPAIVG
CYP189B1 Frankia sp. EAN1pec
YP_001504949.1
ABW10043.1
47% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MTEDLYWDPFDREFHVDPHPVWHRMRDEAPVYRNEKMDFYALSRFADVDAAHLDTATYSSAYGTVLELMS
PEPLKTGQIIFMDPPIHTTLRVLVSRAFTPRRVGGLEGHIRQICAELLDRQVGGGGFDYIQDFAALLPSM
VISQLIGVDPADREEIRHTIDQTFHLDPEKGMVNDISMAASAKFHAYLSEQLEARRAAPRDDMMTALVQA
EIATDGGTRQLTTSEAADFTALLVAAGTETVARLLGWACDALEAHPDQRAELAVDPSLLGNAVEETLRYE
SPSPVQGRVTTRDVELHGTTIPARSKIILLTASAGRDGRRYDDPDRFDIRRRVDSHVAFGRGAHFCLGAA
LARMEGRIALEETLRRFPTWEVDRDNAARLHTSTVRGYEKLPIVV
CYP189B2 Frankia sp. EAN1pec
YP_001504992.1
ABW10086.1
49% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MAELYWDPFDEVIDVNPYPLWKRMRDEEPVYRNDKFDFYALSRHADIDAAHVNADTYSSAHGTILEIMKP
EPMPPGFMIFTDAPAHHLLRSLVSRAFTPRRIAALEEHIRVLCAEMLDPQIGAGGFDYISDFAAQLPSKV
ISQLIGVDPADREEVRRTIDLTFHIEEGVGMVNETSHAATIKLRTYFAGLIEDRRRSPRDDMITGLAEAE
VTDGNGERRRLTTPEAASVTNEIVSAGTETVARLLGWACVLLEAHPDQRAELAADPSLLSNAVEETLRYE
APSPVQGRMLKNDVELHGTTIPTGAKVLLLTGSAGRDGRRYTDPDRYDIHRKFDGHVAFGRGAHFCLGAA
LARMEGRIGIEETLRRFPNYQVDHDSAVRLHTSTVRGYEHLPLVV
CYP189B3 Frankia sp. EAN1pec
YP_001508614.1
ABW13708.1
48% to CYP189A4 Mycobacterium smegmatis
MTELSWDPFDKVIHLAPYDVWRRMRDEAPVYRNDRLDFFALSRHADVEAAHRDPATYSSAHGTVLEIMSP
EPMQTGLIIFIDPPTHTELRTLVSRAFTPRRISALEDSIRALCAEMLDPQVGGSGFDYVQDFAAQLPSKV
ISELIGVDPADREDVRQLIDQTFHLEEGAGMINDISFGAQIKLHTYWSEQIELRRRQPRDDMMTALVEAE
VKSETGSRRLTTQEAADFTNLLVSAGTETVARLLGWAGFVLAAHPDQRAEITADPSLIGNTIEELLRYEA
PSPVQGRVLTREVELHGTVLPAKSKVLLLTGSAGRDERKYPDADRFDIHRRFDSHVSFGHGVHFCLGASL
ARLEGRVALQETLHRFPEWDVDHDRAVRLHTSTVRGYEKLPITLG
CYP189B4 Frankia sp. EAN1pec
YP_001508508.1
ABW13602.1
49% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MTDDLYWDPFDKEIDVNPHPLWKRMRDEAPVYHNEKFDFYALSRFTDVDTAHLDPATYSSKYGTVLELMK
SEPWDTGQIIFMDPPTHTTLRVLVSRAFTPRRVGGLEGVIRDLCAELLDPQVGGGGFDFVQDFAAQLPSL
VISQLIGVDPADREDVRKMIDGTFYLDPEKGMFNETAMAATAKFHGYLNGQIQERVKNPRDDMMTALTQA
EITTDDGTRRLSLSEATDFTALLVSAGTETVARLLGWACVLLAAHPDQRADLAADPSLLGGAVEETLRYE
APSPVQGRVTTRDVELHGTEIPAKSKVLLLTGSAGRDDRKYDDPDRYDIRRRFDSHVSFGHGVHFCLGAA
LARMEGRIALEETLRRFPTWDVDHGNTVRLHTSTVRGYEELPIIV
CYP189B5 Frankia sp. EAN1pec
YP_001510780.1
ABW15874.1
47% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MPPVTGRARAWRRELAVLGGSQRGPGTEKGSTVTEDLYWDPFDKIIDVNPHPLWRRLRDEAPVYRNEKHD
FYALSRHADVDAAHVEPETYSSAHGTVLELMGPEPFNTGQIIFMDPPTHTLLRVLVSRAFTPRRVGGLEG
SIREICAELLDPQIGGGGFDYVQDFAAQLPSLVISKLIGVDEADREEIRQTIDQTFHIEEGKGMINDVSF
AAQIKLHTYFSEQIDARRTAPRDDMMTGLAEAEITTDEGARRLTTSEAADFTNLLVAAGTETVARLLGWA
GDLLEAHPDQRAELAADPSLLGNAVEETLRYESPSPVQGRVNTREVELHGTTIPAKSRILLLTSSANRDE
RKYPDADRYDIRRNFDSHLAFGRGPHFCLGAALARMEGRIALEETLRRFPNYEVDRDNAVRLHTSTVRGY
EKLPIKV
CYP190A1 Mycobacterium smegmatis
MSMEG4807 TIGR pksS
76% to 190A4 Mycobacterium vanbaalenii
63% to 190A5 Mycobacterium vanbaalenii
77% to 190A2 Mycobacterium avium subsp. paratuberculosis
38% to 123A2
MTTPQMIFDPFSEQYFENPFDIYRQMRDDAPLYYDSEQDFYALSRHEDVA
AALKDHEAFSSSRGCDLAMVKGDEPPQKSIIFMDPPEHRHMRSLLNKAFT
PRAVQAQRDTVVEQVEHYLGQIDSDEFDVVQDFSGPFPVEVITRMAGVEP
EYRQQVRHWIDTSLSREPGQVAYSEAGMKANIDTAMYYYSLVQKRRENPQ
DDMISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAM
VTFAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSG
TIPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGIHSCL
GAALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR
CYP190A2 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017229.1
CDS complement(151750..152955)
Formerly 270A1
MTKPKLVFDPYSEDYFNNPYEIYRRMREEAPLYYDEKEDFYALT
RHVDVAAAFKDYETYSSARGCDLAMVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTP
RAIQSQRETIIEVVDKYLSAADPDNFDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
IDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQDPQDDMISRLIAAEIPGENG
QMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVIFARHPDQWQKLQEDRDKIPGAVE
ELLRYEGPVQYNVRYTLKEAHVSGGVIPAGKPVFLCGAAANRDPEAFTDADTFDIERD
QTEAQHLGLGYGIHSCLGAALARLESRIALERLLDFMPRYDVDWAGCRRVTMQNVAGW
KNVPVKVLR
CYP190A3 Mycobacterium marinum
No accession number
Tim Stinear
MM4733
69% to 190A2 Mycobacterium avium subsp. paratuberculosis
38% to CYP123A1
Formerly 270A2
CYP190A4 Mycobacterium vanbaalenii PYR-1
ZP_01205773.1, EAS26765.1
78% to 190A2, 76% to 190A1
MTAPELRFDPVSQDYFDNPYEIYRRMRDEAPIYYDAEEDFYALTRHEDVAAALKDHEAFSSARGCDLGMV RSEDGPVKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETVIELVEHYLSKVDPDNFDVVQDFSGPFPVE VITRMAGVPEEFRQQVRHWIDKGLERKPGQIEWSDENMQANIDSGVYYYGLVQERRRNPQDDMISRLIAA EIPGENGEMRKLDDIEITGFTSLLGGAGAETVTKLLGSAVVEFARHPEQWQMLLDDRNLIPDAVEELLRY VGPVQYNVRYTVKEAHVPSGTIPAHKPVFLMKAAANRDPRAFDNAETFDITRDRTQAQNLGLGYGIHSCL GAALARTETAIALEHLLDFMPRFEVDFSGLQRVNMQNVAGYHHVPVKVLR
CYP190A5 Mycobacterium vanbaalenii PYR-1
ZP_01203858.1, EAS24850.1
68% to 190A3
MAVVDVGRDPVVFDPFSEEFYRDPQGCYPRLRAEAPVYYNATYDFYALSRHADVAAGLKDFATYSSAYGV DLGMVRRGEKVPAKMIISIDPPEHRAMRSLVNKVFTPRAIEALRTMVTDTVTRFLSAVRGDSFDVVQDFS VYFPVDVITQMLGVPEKYRQQVRLWIDESLHREPGQIDMSEAGMQAMAETWLMYYDLIKQRRADPRDDMI SALIAAEVEREDGTVDRLKDSEIAGFATLLGGAGAETVTKLVGSAVVTFARHPEQWQQLLDDRGKIGVAI EELLRYDAPVQYNVRRSNHPVTLHGVTIPAGAPVFLLGASANRDPDAWTAPDVFDINRDRTEAQNLGFGY GIHSCLGAALARLESSIALDMLLDFMPRYGVEWDGCRRVSMQNVSGWANVPVRIL
CYP191A1 Mycobacterium smegmatis
MSMEG2565 TIGR
81% to 191A4 Mycobacterium vanbaalenii
69% to CYP191A3 Mycobacterium marinum
MTTTVKPPVTEAVTGEFSYDPFDPAVMADPTPYYRVLREKYPLYHIEKWD
TWALSRFSDIWEVLEVNDGTFVASEGTLPAATVLAEHNDGAVPDPPWHPM
PFHANFDTPIYDSVRRCTSPQFRPRSVTKLADRIRTLANERLDELLPRGQ
FDLTQDYGGIVAASVVCELVGLPVDLAADVLATVNAGSLAEPGSGVEVAN
ARPGYLEYLTPVVQRRRAGEGRELPIVDNLLQYRLPDGSAFSDLEAAVQM
LGVFIGGTETVPKIVAHGLWELTRHPEQLAAVRTDLDANVPIAREEMIRF
CAPAQWFARTVRKPFTLHGTTLQPGQRVITLLASAGRDEREYPDPDSFIW
DRRIERLLAFGRGQHFCLGVHLARLEITIMVTEWLKRVGEFRVDERAARR
PPSSFQWGWNNVPVEV
CYP191A2 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017240.1
CDS 48827..50038
formerly 280A1
MDFAYDPFDAEVMANPLPYYRILRDHHPVYYMPQWDTFALSRFD
DIWRVLEVNNGTFVASEGTLPPASVLAQHNDGPVDDPPLHPLPFHAMFDADLYGEIRR
THSRPFRPRAVTDLEGRIRTLANERLDELLARGSFDLTQEYGGVVVATIVCELLGIPT
DLAPQVLAAVNAGSLAEPGVGVDTGQARPNYFEFLLPAVQRRRADPSGPPLEVVDGLL
GYQLPDGSALDDLEVATQMLCIFIGGTETVPKIVAHGLWELSRHPDQLAAVRADPQHN
IPVAREEMIRYCAPAQWFARTVRKPFDIHGQTPNPGQRVITLLASANRDEREYPDPDD
FVWDRPIRRSLAFGRGQHFCIGYHLARLEVAVLLQEWLRRVPDYAIRADAATRLPSSF
QWGWNKIPVEV
CYP191A3 Mycobacterium marinum
No accession number
Tim Stinear
MM0399
81% to 191A2 Mycobacterium avium subsp. paratuberculosis
29% to CYP123
formerly 280A2
CYP191A3 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 191A3 M. marinum = ortholog
formerly 280A2
CYP191A4 Mycobacterium vanbaalenii PYR-1
ZP_01206303.1, EAS24065.1
31% to 123A1
MVDIPARHRRQRRGPDHVRRAQQQDAGAVAGIGFPGRPGDSGSHADQAGPAGRLHQGTGTPLRAVVGVDG QALARLLHHHLQVQRGDPLLGARRRLGLLRESLPVVEGQPAGRDRHLDERRPRTARRLGGLHPGRPAPVP AAVSAKMSAAQQPDCRPGRRPFTYDPFDPDVMADPLPYYRVLRDEHPVYYLQKWDTYALSRFDDIWNVLE INDGTFVASEGTLPSAAVLAGHNDGPVADPPLHPMPFHANFDAPIYDEVRRCTAAPFRPRNVAKLADRIR VLANERLDELLPRGRFDLTQEYGGIVAASVVCELVGLPADLAPDVLATVNAGSLAQPGSGVEVANARPGY LEYLTPVVARRRAGQGSELPIVDNLLNYRLPDGSALSDTEAAVQMLGVFIGGTETVPKIVAHGLWELSSR PDQLAEVRSDMDANVPVAREEMIRYCAPAQWFARTLRRPFTLHDTTMRPGQRIISLLASANRDEREFPDA DRFVWNRPMPRLLAFGRGQHFCLGAHLARLEIAIMVTEWLKRVPEFRVDTAAAFRPPSSFQWGWSELPVE V
CYP192A1 Caulobacter crescentus CB15
GenPept AAK24959, C87620
NC_002696 complete genome 3214816..3216192
35% to 173A1 40% to BAC45822
1 MDADVRSAPL IPPAPKVHPR QLGGSFVGEL RIALEMSRNL MGAWCEEDFD NLFTPYVFMG
61 QPGMVVSDPA AARRILSSPN YVRPVKAARS VRPIAGDGLL LSEGETWRRQ RKSLAPVFTP
121 MAVEGLLPHF VAAGASLAEA LSGHARADLS EAFHHATLDA VLSALFSRRA DAQGDQLAYM
181 VRRYMEGPAH FNLMDFVSRG ADDLTFLDVE RRRQGAAWFQ AVEHLIAQRQ AHPHAEARDL
241 LDRLLAARDE DGAPLSNQEI RDQCGTMLVA GFETTSRLLF WATYLLALDP ATQDRLRAEV
301 LAAPAAAVRT LDDLQAWPLM RSVLFETLRL YPTAPLLARE AIGPDTVMGH AVVPGQIITI
361 SPWLIHRHRK LWDAPTAFVP DRFIDQPHPW GIEAFLPFGA GPRVCIGASF ALAEAQIVLA
421 SLLERFEIGL VSDRPVIPIA SITLGPDHAP AFTLTPVS
CYP193A1 Bradyrhizobium japonicum USDA 110
GenPept BAC52277
NC_004463 complete genome complement(7721594..7723027)
33% to 104A2
1 MARGCASRCS RPVSDASPAP RAGTLSGARL ECRLCRFMAL DERCLCVCRC PLLWVMRTRY
61 RARTPCPNRW GQTAAPERAS LAGHSRETAL STAPRIDIDP AAFWADPYPM LANMRKEAPI
121 AFVPQLGSTL LTSRDDISIS EKQIDVFSSH QPAGLMNRLM GHNMMRKDGE AHQVERRAMF
181 PTVSPKTVKG YWTALFQAHA DRIIDAIEPG RIDFMRDFAL PFSGECLKSI TGLTNIGFAE
241 MDAWSQGMIE GIANYVGDPA VEARCHAATS GIDAAIDDML PVMRKNPDQS ILGVLLASGM
301 PMESVRANVK LAISGGQNEP RKAIAGTVWA LMTHPEQLDL VRRGEVTWLQ AFEEYARWIS
361 PIGMSPRRIA KPWSIRDVAF ELDERVFLMF GSANRDEKHF ERADQFDVRR DTSKSVAFGA
421 GPHFCAGAWA SRAMIADVAL PTLFARAGRI EIADDEPVRI GGWAFRGLQN LPARWLH
CYP194A1 Bradyrhizobium japonicum USDA 110
GenPept BAC48170
NC_004463 complete genome complement(3198120..3199340)
36% to 176A1
1 MSDVSEPVAH PPVTDWVNDF DHTDPQWTDD PFPIWDELRA ASPVVHTERF LGCYMPTTYE
61 AVREIANDTE HFSSRRIIVR DVRPEIARNA APPITSDPPV HKPAKQLLLP PFTPDAMKKL
121 EPRVRTICNE LIDGFISDGK VDAAARYSKY IPVRAIAHML GIPESDSDLF VNWIHMILEL
181 GIKDETMLLQ AVQEMSAYFR THIEERRSRP TDDLISYLMN AKDKEGQPLE ESHVLGSLRL
241 LLIAGIDTTW SAIGSSLWHL ARTPADRERL IAEPGLIPIA VEELLRAYSP VTMAREVVKE
301 TTISGCPVKA GNMVLLSFPA ANRDPKMFPD ADKVVIDRRE NRHAAFGLGI HRCVGSNLAR
361 MEMQVALEEW LKRIPDFRLD PAGTVTWSQG TVRGPRQLPF LLGKAM
CYP194A2 Rhodopseudomonas palustris
NZ_AAAF01000001
complement(3427752..3428951) gene = Rpal3007
74% TO 194A1
MSERAPVTDWVNDFDHTDPRWTENPYPIWDELRSAGPLVHTDRF
LGCYMPTTFAAVKEISYDTDHFSSRRVIVRNVRSESPPPAPPITSDPPEHKPAKRLLL
PPFTPDAVAKLEPRVRAICNELIDAFIEDEGCDAATAYTKHIPVKTICHMLGIPEDDS
DIFIRWIHEILELGINDDAILMKAVFEMSTYFQGHIAHRKQKPTDDLISTLMNARDDK
GQPLSDAHVLGSLRLLLIAGIDTTWSAIGAALWHLATHPADRERLLAEPELMPTAIEE
FLRAYSPVTMAREVMKETSIAGCPVKPGNMVLLSFPAANRDPSVFPEADRVMIDRKEN
PHVAFGLGIHRCVGSNLARMEMTVAIEEWLKRIASFRLDPSQKVRWSEGTVRGPRSLP
LLFGKPS
CYP194B1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE12854399 78% to CYP194B2
CYP194B2 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE12855425 52% to CYP194A1
CYP195A1 Bradyrhizobium japonicum USDA 110
GenPept BAC48121
NC_004463 complete genome complement(3142651..3143883)
34% to 107P2 37% to BAC51802
1 MNADAKELAA SFDLEKLTPE FYDNPYPTYR ALRENEPVKR LPNGTVFLTR YDDLVTTYKN
61 TKSFSSDKKR EFAPKYGNTP LYEHHTTSLV FNDPPAHTRV RRLIMGALSP RAIAGMEADL
121 IKLVDGLLDA IAAKGSCELI EDFAASIPIE VIGNLLDVPH DERTPLRDWS LAILGALEPV
181 VSPEAAARGN KAVKDFLSYL ETLVARRRGK PGNPERDVLT RLIQGEGNGE ENGERLTEKE
241 LLHNCIFLLN AGHETTTNLI GNGLVALDRH PDQKQRLIDH PDMIKTAVEE MLRYESSNQL
301 GNRMTTERVE LGGVMLDAGT SVTLCIGAAN RDPAQFPDPE SFDIARTPNR HLAFATGAHQ
361 CAGMALARLE VAIAISRFLA RFPNYAVNGR PVRGGRVRFR GFLSVPCAIG
CYP195A2 Rhodopseudomonas palustris
NZ_AAAF01000001
305794..307173 gene = Rpal0264
74% TO 195A1
MSVEEAALAAGPGPPTGRMTCVAPVPAARPDPQISRPFRQRRKS
PIDVKNGNDMETAPAELAEAFDLARLTPDFYDNPYPTYHALRAHQPVKRLASGGYFLT
RYDDLVAVYKNTTLFSSDKKREFTPKYGDSLLFEHHTTSLVFNDPPSHTRVRRLIMGA
LTPRAIAGMEPDLIALVDRLLDAMAAKGRVDLIEDFASAIPIEVIGNLLGVPHDERGP
LRGWSLAILGALEPVIGPEAFALGNAAVAEFLGYLDTLIARRTAEPGDPERDVLTRLI
RGEAGGEKLTAKELLHNCIFLLNAGHETTTNLIGNGLVTLAANPDQKRRLIAEPALIK
TAVEEILRYESSNQLGNRITTAEVEIGGVSMPANTSLTLCIGAANRDPAQFADPDRFD
VSRSPNRHLAFASGPHQCAGMALARLEGAIALSRFLAHFPDYVLDGPPQRGGRVRFRG
YLGVPCRLG
CYP195A3 Burkholderia fungorum
GenEMBL NZ_AAAJ02000119
3110..4828 gene = Bcep1797
64% to 195A2
MGAAIDVEVGALGDACIGNPDRVGVDDAGVRTARQRNERFVMVG
GKGRGALNDEVHGRRRSDTVEGGRAARAANPAIVTVRRFASPRAIRAKRCCARHPAWR
RAILRRAVHTDESNDASQPPRTPTVACTPSRRAKSGTRTQRHPRRGAPLRRHRMTPAT
ASDASTLARDFDLRHLNPAFHADPYPVYHALRAHEPVKRMPDGSLFLTRFRDVQAVYR
DPKTFSSDKTVEFKPKYGDSPLYAHHTTSLVFNDPPRHTRVRKLIAGALTARAIAAME
PGLVRLVDGLLDAAAARGRIDLIDEFASAIPVEVIGNLLDVPHTERAPLRDWSLAILG
ALEPSLSEAQLERGNRAVSEFIDYLRDLVARRRREPGDPQHDVLTRLIQGEAGGEQLS
EAELLQNCIFILNAGHETTTNLIGNGLVTLTQWPEQRAALLHEPSLIESAVEECLRFE
SSNQLGNRMATVDTEIGGVAVARGTPVTLCIGAANRDPEQFADPDRFDIRRDPNRHLA
FGFGIHQCAGLSLARLEARIAIGRFVQRFPAYRVNGEPTRGGRVRFRGFAAVPVELEP
AGRRTA
CYP195A4 Stigmatella aurantiaca
GenEMBL AJ421825 complement(4978..6231)
66% to 195A2
note = ORF8
MLRSVSASRPPSPANPVAAFDLARLDDAFYADPFPLYRAMRERD
PVHRMPDGSLFLTRWADLDCIYRDTRTFSSDKRAEFGAKYGDAPLFEHHTTSLVFNDP
PLHTRVRRLIVGALTPRALSTMEPGLRTLVDRLLDGLAVKGAADLIEDFAAAIPIEVI
GNLLDIPTEERGPLRGWSLAILGALEPRLTAEQEACGNEAVTEFLDYLRILVAQRRAR
PGDPATDVLTRLIQGESDGERLTETELLHQCVFLLNAGHETTTNLIGNALELLARFPD
ERARLLRAPALIPTAVEEVLRYESSNQLGNRRVAEDTEIGGVAVPTGTFLTLCIGAAN
RDPARFEDPEHFDVGRQPNRHLAFAGGAHTCAGMNLARIEARIALAAFLARFPDYALT
APPVRARRARFRGFTAMPTRLGSLR
CYP196A1 Bradyrhizobium japonicum USDA 110
GenPept BAC46159
NC_004463 complete genome complement(972593..974053)
36% to CYP136A1
1 MLPRSAGAGR NKVAVARCPF GQPTGALVMS MQNVAAPALQ FTAPRRNELT HIPGDEGWPV
61 IGKTFQVLAD PKGHIEANGA KYGPVYRTHV FGETNVVLLG PEANELVMFD QQKLFSSTHG
121 WNKVLGLLFP RGLMLLDFDE HRLHRKALSV AFKSGPMKSY LSDLDRGISA RVAQWKAKPG
181 EMQLYPAMKQ LTLDLAAASF LGADIGPEVD EINRAFVDMV AAAVAPIRRP LPGTQMARGV
241 AGRKRIVAYF RQQIPLRRGN HGGDDLFSQL CRATHEDGAL LSEQDIIDHM SFLMMAAHDT
301 LTSSLTSFIG ELAANPDWQD RLRAEVLALG LAPGAPSSFD DLEKMPLSEM AFKEALRIKP
361 PVPSMPRRAM RDFTFKGFRI PAGTAVGVNP LYTHHMKDIW PEPDRFDPLR FTEEAQRNRH
421 RFAWVPFGGG AHMCLGLHFA YMQAKCFARH FLQNIEVSLA PGYKPDWQMW PIPKPRDGLK
481 VRVKAV
CYP196A2 Rhodopseudomonas palustris
NZ_AAAF01000001
complement(2360490..2361869) gene = Rpal2059
70% TO 196A1
MSIQVADSSLVARLSPPKPSALAHVPGDEGWPIIGRTLAVLADP
KGEVEKMARTYGPVYRSRVLGETSITLLGPEANELVLFDNTKLFSSTHGWGPILGRLF
PRGLMMLDFDEHRLHRRTLSVAFKAGPMQSYLAELNAGIAHRVAEWRARPGEMLCYPA
MKQLTLDLAATSFLGTAIGAETEEVNRAFIDMVAASVAPIRKPWPGTAMARGVKGRQR
IVAYFAEQIPIRRAKGGDDLFSQLCRATHDDGALLSNQAIIDHMSFLMMAAHDTLTSS
LTSFVAALAAHPEWQQKLREEIAGLGLKPGEPISFEQLDALPLTEMAFKEAMRLRPPV
PSLPRRATRAFSFKGYTIPAGTMVAVNPLFTHHMPEIWPNPDQFDPLRFTDEASRGRH
RFAWIPYGGGAHMCLGLNFAYMQAKCFAVHLLQHLDLSLPPNYQASWQMWPIPKPKDG
LRVNVAPLN
CYP196A3 Novosphingobium aromaticivorans
NZ_AAAV01000177
complement(59115..60509) gene = Saro3719
57% TO 196A1
MASIAPDSRTDLHTERANPHWVRLGGDHKLDHVPGEDGWPVLGT
TLMQLADPLGFQRRMVETHGPVFRTRSFGRRGVNLIGADANELVLFDRDRLFSNEQGW
GPVLNLLFPRGLMLMDFEAHRVDRRALSIAFKPEPMRAYCSVLNTGIAQAVQGWGGQM
RFYDAIKALTLDTAASSFLGLPLGPEADRLNKAFVDMVQASGGVVRRPLPFTRMGKGV
AGRRLMVEYFGRLVRERRADPGQDMFSQFALATREDGSLLPEDVVVDHMIFLMMAAHD
TITSSATVLFWQLARNPDWQDRLRAEARAVTGGDGLPLAYEDLGRMELTEMAFKEALR
FMPPVPNMPRRALRDFEFGGYRIPAGTPVGISPAAVHADPAHWPEPDRFDPLRFTPEN
VSGRHKYAWVPFGGGAHMCLGLHFAYMQVKLLVSHILTRYEVAMQPGPAPSWQAWPIP
KPRDGLRVEMRRIC
CYP197A1 Bacillus halodurans
GenPept BAB04298 GenPept NP_241445.1
34% to CYP174A1 Halobacterium sp. NRC-1
1 MPTNTMPTGP KGNPVLGNTI EFGKDPLQFI TRCSQEYGEI VRLRFERERD TFLLNDPKHI
61 QYVFMNKGGE FSKGYQQDPI MGLVFGNGLL TSEGSFWLRQ RRLSQPAFHP KRIADYADTM
121 VGYCERMLNT WMDNDTRDIN DEMMQLTMAI ATKTLFDLDL HKGDTQEASR SLDTVMTAFN
181 EQMTNVFRHV LHLIGLGKLV PPVSRELREA VESLDKMIYS IIEERRKHPG DRGDLLSMLI
241 STYDEDDGSY MTDRQLRDEI ITLFLAGHET TANTLSWAFY LLSQHPHVEE KLYQEVSQVL
301 GNRPATLEDM PKLSYAEHVI KETLRVQPTV WLISRRAEKD VTLGDYHISA GSEIMISQWG
361 MHRNPRYFND PLTFLPERWD NNDNKPSKYV YFPFGGGPRV CIGERFALME ATLIMATIVR
421 EFRMELVDEL PIKMEPSITL RPKHGVTMKL RKR
CYP197B1 Nostoc punctiforme
NZ_AAAY02000014 GenPept ZP_00110793.1
complement(44530..45885) gene = Npun5259
44% TO 197A1
MVADVFELPAPSVNSIVGHLFELGQDPLGFLTRCRDYGDIVPLQ
LGLTPSCLIINPEYIEEVLKNRNDFIKSRGLRALKSLLGEGLLSAEGESWFWQRRLAQ
PVFHQKRINGYSQTMVEYTNRMVQTWHDGETHDIHEDMMRLTLQIVMKCIFSDDIDAG
EAKVVADALDVAMQWFESKRRQNFLVWEWFPRPENIRYRDAIAQMDEAIYKLIQERRN
GGEKTNDLLTMLMEAKDEQTLQQMDDKLLRDEVATLMLAGHETTANTLSWTWMLLAQN
PGVREKLESELNQVLQGKLPTLEDLGQLVYTQQIIKESMRLYPPVPLMGREAAVDTQI
GDYEIPQGMAIMISQWVMHRHPKYFENPEAFQPERWTQEFEKQLPKGVYIPFGDGPRI
CIGKGFAQMEAALLLATIAQRFQIDLVPGYPIVPQPSITLRPENGLKVQLKQIALDTS
K
CYP197C1 Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
ZP_04000803, ABTX01000013.1 3913-2567
41% to CYP197A1 Bacillus halodurans (Firmicutes),
41% to CYP197B1 Nostoc punctiforme (Cyanobacteria)
1 MMSSDTPPVT DEMPPGPDGL PVVGNYPSYI REPFEFMTRN AREYGDIVGW EERNGPVYQL
61 NHPDHIEQVL VQNNQNYVKG DAFQSTLGPI TGSGILNSEG AIWRRNRHLI QPAFHPNRIE
121 EYSEMMTGYT EEMLETWSDG ETREIHEDMM TVTLKIVSRA LFGVDIDDHV EDIGEALESF
181 MEASESLSHY VLPEEIPTPS RKQIQGAREQ LDDVVYELIE DRRANPGEQD VISMLLDVTD
241 DDGNTLSTEQ IRDEVVTLLL AGHETTALSL SFTAYALARH PEAEAKLVEE LDEVLDGRTP
301 TMSDLSELTY TEQVVKESMR LYPPVPGIVR EPVKPDIIGG YEIPAGATVR MHQWVVHRDE
361 RWYDDPLAFE PERWTDDLEQ SIPKLAYFPF AAGPRRCIGD RFAMLEARLL LATIYQKYHL
421 ELTPGTELDL MATVTARPKS EIEMTVERR
CYP198A1 Xanthomonas campestris pv. Campestris str. ATCC 33913
GenPept AAM42184
32% to 174A1
1 MRRPAFPASV MNSSGAVWQH KRRTLMPAFR AALVRESAMQ ASAATRSLLH ELGDSCATQD
61 MRTLMTGLCA QLGAGFLLGD SANAADLLRM LPMVDAISKQ TRRQSLAPTW WPSSGRRRLR
121 RLRADIDMAL DRILMQSTQR PPRAASVLAL LLAETARDDG DWCRDEAAAI LMSALEPMSA
181 ALTWTLLLLA QHPHIAQEVA QEASALDGAD VASGTSLLDR LPQSRACVKE SMRLYPPAWI
241 TARIAQRDAT LNGFHVPRGT QLLVSAWVVH RDGRHFPDPE IFLPARWLDD SATHSLTRYS
301 YFPFGGGPRS CIGCMLALTQ MTIVIATVLH ACSLHLAPDA RPSPFPALVL RPMDVRIALR
361 PRVIRSVVPS RAHASPVRLA SVTPND
CYP199A1 Bradyrhizobium japonicum USDA 110
GenPept BAC46313
NC_004463 complete genome 1159976..1161184
39% to CYP145
1 MSAPGSAASG VPHLDVDPFD MNFFADPYAA HELLREAGPV VYLDKWNVYG VARYAEVHAV
61 LNDPATFCSS RGVGLSDFKK ETPWRPPSLI LEADPPAHTR TRAVLSKVLS PTVMKQVRDR
121 FAAAAEERVD ALIEKRSFDA IADLAEAYPL SIFPDALGLK SEGREHLIPY ASVVFNAFGP
181 PNQLRQEAIA RSTPHQAYVA EQCQRENLAP GGFGACIHAQ VDEGAITASE APLLVRSLLS
241 AGLDTTVNGI GAAVYCLARF PEQWQRLRGD LSLARSAFEE AVRFESPVQT FFRTTTREVE
301 LSGATIGEGE KVLMFLAAAN RDPRRWDKPD SYDVTRRSSG HVGFGSGIHM CVGQLVARLE
361 GEVMLTALAR RIAKIEITGE PKRRFNNTLR GLDGLPVTIT PA
CYP199A2 Rhodopseudomonas palustris
NZ_AAAF01000001
3590168..3591556 gene = Rpal3146
78% TO 199A1
MRPSGLGAAAADRRDFGGRDAPVMGMSAANACADIRTCHGISQV
AIEEDNMTTAPSLVPVTTPSQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPVVYL
DKWNVYGVARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRT
RAVLSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVFPDAMG
LKQEGRENLLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGAC
IHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSLA
RNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRY
DITRKTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNTLR
GLESLPIQLTPA
CYP199A3 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha06678
Submitted to nomenclature committee 12/13/04
56% to 199A2, 53% to 199A1
CYP200A1 Bradyrhizobium japonicum USDA 110
GenPept BAC49097
NC_004463 complete genome 4251077..4252333
39% to 107L2
1 MAPRLDFTSE AFFRDPPAAI AALRASGPVV ATRFPLVGDV WITTTHDATA EVLKDGTTFT
61 LRKEDGKVAG LRWWMPKLVT TIANNMLTMD EPDHTRLRSI VDEAFRRRAI VAMEPRIRAI
121 ADGLANDLFA DGSPADLVQC YARILPVSVI CELLGLPAAD RPRFIAWANK MSSLTNVVSF
181 FRLLFAFRKM RAYLERQLQI ARVRGGEGLI AELVQVELEG GQITPDEMVS MVFLLLAAGS
241 ETTTHLISGS VYELLRNPAL RDWLEEDWSR ISLAVEEFLR FVSPVQFSKP RYLRRDVELA
301 GVRLKKGDRV MVMLAAANMD PAVHDRPERL DLTRKPNRHM SFGTGIHFCL GHQLARIEAT
361 CALQALLARW PKLELAVDPA QIHWRKRPGM RAIARLPVVA GGNRRPSRGA AAEPLLAD
CYP201A1 Bradyrhizobium japonicum USDA 110
GenPept BAC45822, NP_767197.1
NC_004463 complete genome complement(596460..597827)
35% to 173A1 40% to AAK24959 CYP192A1
1 MNIASVRRPI VPPTPPRAPD DMSFLGRVAV IRQNMIATWG QRAYEEDVLE GRFFLHKSFI
61 LNRPDAIRHV LLSNYENYTR TPAGIRMLRP VLGEGLLIAE GHAWTFQRRT LAPAFTPRAT
121 ANLVPHMTAV LDETIAKLDA RSGETVDLRE TMQRMTLEIA GRTMFSFGMD RHGPTLRNFV
181 VEYGERLGRP YFLDMLLPVS WPSPMDFARA RFRKRWTEFV AMLIAERRAA GKKDGAPPRD
241 LFDLMDEARD PETGKGFSDE QLIDEVATMI LAGHETTATA LFWALYLLAL DPDTQEEVAS
301 ETRGEHLDSM ADIDRQKFTR AVIEETMRLY PPAFLIARAA RAKDNAAGIE IGRGDIIMIA
361 PWLLHRHEKL WDQPNAFVPK RFMSTEAPDR FAYLPFGAGP RVCVGAPFAQ AESVLALARL
421 IGAFRVELVD TVPVIPHGVV TTQPDRSPMF RITRR
CYP201A2 Rhodopseudomonas palustris
NZ_AAAF01000001 GenPept ZP_00010020.1
complement(1953073..1954536) gene = Rpal1705
65% TO 201A1
MGSAGAFSLPVSHTTFVEQQRGSGFEVSIAAIDDRPASRAPLIP
PTPPRAPENLSALGRLAAIRHNAIASWGDRAYQDDVVRGRFFAHSSYILNTPDAIRHV
LVDNTDNYRRTATGIRVLRPMLGEGLLLAEGRAWKHQRRTLAPAFTPRAVATLVPHMA
SATDEVVEGLRRKTGVPLDLRETMQHLALEIAGRTMFSFEMGTHGQALRGFVIDYGTR
LASPRFLDLLLPLGWPTPQDVSRALFRRRWTRFIGELIAARRAAGKAEGAPPRDLFEL
MLAARDPETGEAFSDAQLGDQVATMILAGHETTATALFWALYLLALDPDAQERLANEV
RRVGFGGTEIERLPFTRAVLDETLRLYPPAFLIVREAAGPDRVAGFAVRKHDVMLIAP
WLLHRHDKLWSDPNAFVPERFLPGVPSPDRFAYLPFGVGPRVCIGAHFALVEATLALA
KIVGTFRIELIDTEPVIPIGVVTTQPDRSPLFRLTPR
CYP201A3 Magnetospirillum magnetotacticum
GenEMBL NZ_AAAP01000877
60% to 201A2 runs off the end
675 LILAGHETTAV 643
640 PLLWACTLLALSPETQERVAAESGQADKPFTRAVIDETVRLYPPAFVLARR 488
487 AAGVDTLGGETVQPGDSVTISPWLLHRHRRLWRDPDAFDPGRFLPGASPVPRFAYLPF 314
313 GAGPRVCIGAAFALTEATLALSRIVGRFRLARADARPVLP 194
AAVVTTQPDHAPAFRLTLRT* 131
CYP202A1 Sinorhizobium meliloti
GenPept CAC45831
40% to 107P1 56% to 202A2 NP_108561
1 MSIAPGITID GPARRVSLDV RNPRFFRNPL PAYAALHAQC PAFFWEEPQQ WFFAGYEQVN
61 SLLRDRRFGR QILHVATREE LGMPEPKPHL KDFDALEAHS LLELEPPAHT RLRTLVNRAF
121 VSRQIEELRP EIEALSHAVI DGFEKDGETE LLKTYAETIP VTIIARMLGI PVEAAPRLLD
181 WSHRMVKMYV FNPSLETEFD ANNASAEFAD YLKGIIAEKR TNPADDLLTH MITSEKDGER
241 LSDAELISTT VLLLNAGHEA TVHQIGNAVR TILQSGLSPA ELFSDEKATE RTVEECLRFA
301 APLHIFQRYA LMDIELENGI ALRKGDKIGL MLGAANVDPR KFSSPDTFRP DRNEGANVSF
361 GAGLHFCIGA PLARLELQIS LPILFRRLPG MRLKNEPPVK DAFHFHGLER LDLVW
CYP202A2 Mesorhizobium loti
GenPept NP_108561
42% to 107P2 56% to 202A1
1 MTNSTLPYLA FDPATRRLRL DPHEPAFFLN PYEAYGFLHD VSNAFFWEEF GFWCFGGFDD
61 VNRLLRDRRF GRQNPAGIPD SRGVGQDRSH LRAFDGIEAN SMLELEPPVH TRLRTLVNRA
121 FVSRQVERLR PRVEALANEL IDRFDPTGPV DLLPAFASPL PITIIAEMLG VPVEMGPQLL
181 DWSHQMVAMY IHGRTRETEE TANRAASEFA DFLRGYVAER RRNPGDDLLS LLISAQEDGE
241 RLSEDEMVSS AILLLNAGHE ATVHQTGNAV RSILAQGGDP SRFFTSAEAT AATVEECLRF
301 DAPLHMFMRY AYQEIEIAPG IVVRPGQTIG LLLGMANHDP RAFAEPQAFR PDRADQKNVS
361 FGAGIHFCIG APLARLELQV SLKTLFERHP RLHLAEQSRF RDTYHFHGLE TLAVGF
CYP202A3 Agrobacterium tumefaciens strain C58
GenEMBL NC_003062 complement(1243027..1244274)
63% TO 202A1
locus_tag = AGR_C_2319
MTATFPFLKIDPATRRVSLNARDPAFYNDPNPVYAALHAQCPTF
YWEEQRQWFFTCYDHVSTLLRDRRFGRQILHVASREEIGLPEPLEHVKHFDLAEQHSL
LELEPPEHTRLRTLINRAFVSRHVDKMKPEIEELANRLIEAFEANGETELLSSYADII
PVTMIARMIGIPEEMGPQLLKWSHAYVGMYMFKRTPEDELLADKAAQEFSDYVRRVIA
ERRAEPKDDLLSHMIHTEHKGQYLTDDELVSTTIVLLNAGHEATVHQIGNSVRIILES
GLDPKTLFHDETATERTVEETLRICAPVHIFQRWVLEPVEIDGVQFKRGDKVSLILAA
ANLDPAKFSDPLAFQPDRNEGANVSFGAGIHFCIGAPLARLELNLALPLLFKRLPGLK
IAEPPKVKDVYHFHGLERLDLAW
CYP202B1 Rhodobacter sphaeroides
GenEMBL NZ_AAAE01000131
30501..31682 gene = Rsph2231
48% to 202A2
MQTLSQSPHDRRFLRNPYRFYREARAAGPFFHWEELGLVCTTSY
AAANAILRDRRFGREVPPGRASAVPDHLAPFAAVEAHSMLELEPPRHTRLRNLVLRAF
TSRRIGTMQPEVAALSESLVAAVPEGPFDLLPAFSQRLPITLIARLIGIPESLAPELL
RWSSAMVAMYQAGRTRKTEERAALAAADFSDFLRLHIEARRHAPADDLLTHLIAAEAD
GQQLSTDEIVSTCILILNAGHEAAVHAIGNAAAVLLRHRTPPEALAPPHLLGTVEELL
RFDPPLHLFRRMAYERVEIMGRTIEEGCEVALLLGAANRDPGPWERPDRFLWNRPEKT
HLAFGAGLHFCLGAPLARLELATALPILFGRLPNLQLVKPPSYGDSWHFRGLERLIVSA
CYP203A1 Rhodopseudomonas palustris
NZ_AAAF01000001
2600909..2602096 gene = Rpal2284
35% TO 113B1
MFSFDPYSPIVDADPFPLYKTLRDEYPVFWSEPAQMWILSRYLD
VAGAGSNWQVFSSAKGNLMTELPNRAGATLGTTDPPRHDRLRGLVQHAFMKRNLEALA
EPMREIARDAAEALRGRDQFDFISDFSSKFTVRVLFAALGLPMGDEQTVRDKAVLMVQ
SDPVTRAKGPEHLAAYAWMQDYASSVIAQRRAEPKNDLISHFSMAEIDGDRLDEREVL
LTTTTLIMAGIESLGGFMSMLALNLADFADARRAVVADPALLPDAVEESLRYNTSAQR
FKRCLQSDLTLHGVTMKAGDFVCLAYGSANRDERQFPNPDVYDVKRKPKGHLGFGGGV
HACLGSAIARMAIRIAFDEFHKVVPDYTRTEQQLNWMPSSTFRSPLRLDFAVEQAASR
SAA
CYP203A2 Novosphingobium aromaticivorans
GenEMBL NZ_AAAV01000114
complement(9289..10479) gene = Saro1156
62% to 203A1
MATVIERPQFRFDPYSPAIDADPFPAYKVLRDEYPCFWSEEAGK
WVLSRYDDVLAALQDWRTYSSAKGNLVDEFPGRAGSTLGSSDPPRHDRLRALIQSAVT
KRALEHIIAPARASAQAHLAALADKPVFDLVGDYTSKLTVDLLFYLFALPDEGAQQVR
ENAVLMVQTDPVTRQKSPEHLAAFHWMADYAEKLVASRKANPGDDLLSSFITAEIDGE
KLLDKEVQLTVTTLIMAGIESLSGFMAMFGLNLADYPEARSALVADPSLIPDAIEESL
RFNTSAQRFKRTLTRDVELHGQVMKAGDAVILAYGSANRDERMFENPDVYDITRKPRR
HLGFGGGVHACLGSMIGRLATQIAYEELLKAVPDFRRADAPLDWVPSSNFRSPKSLML
EKKA
CYP204A1 Novosphingobium aromaticivorans
NZ_AAAV01000167 GenPept ZP_00095854.1
16299-17720 gene = Saro2888
30% to CYP51A2 in Arabidopsis 27% to CYP51 M. tuberculosis
MARAATAAGNGLPLLDGGVPLLGHLAQFFRDPVSVLKRGYRSKG
RLFAMNFMGQRMNVMLGPEHNRFFFEETDKLLSIRESMPFFLKMFSPEFYSFAEMDEY
LRQRSIIMPRFKAASMKQYVPVMVEESLNLVERLGEEGEFDLIPTLGPVVMDIAAHSF
MGREFHEKLGHEFFELFRDFSGGMEFVLPLWLPTPKMVKSQRAKRKLHAILQSWIDKR
RAAPLDPPDFFQTMIETKYPDGRPVPDEIIRHLILLLVWAGHETTAGQVSWALADLLQ
NPDYQKVLRGEISSLLGGSDGRDLGWEQAVAMEKMDLALRETERLHPVAYMLSRKARA
DIERDGYVIRKGEFVLLAPSVSHRMEETFRNPDAYDPERFNPANPDAQIESNSLIGFG
GGVHRCAGVNFARMEMKVLVAILLQNFDMELMDEVRPIAGASTYWPAQPCRVRYRRRK
LDGSEAGADMAALARAAGCPAHT
CYP204B1 Saccharopolyspora erythraea NRRL23338
SACE_3928, se: 4309034,4310356 (-) STRAND,
47% to CYP204A1, 30% to CYP51B1 Msmeg
MLSGARPLVGHAGEFIRNPVAMAERGYAECGEAFSVRIPGWTAHMFIGPEHNRFFFSETD
RRLSIRTAYPFFVRMFDPAFYFFAGDDEYRRQRALVLPRFQGRQLENYVATMVDEVCELD
RALGNSGEFDLVRTMGPLVMRIAARAFLGREFSARLENGFFEKFRRFSAGMDPVMAGWLP
LPHLVRSRFAKRELHRLMGELIRQRRRSPVEPGDFLQTLIEARYDDGEVVPDRVLINLIL
LFSWAGHETTTGHISWAVIDLLRNPEALRKVLEETHGVLGSRSFGELTLSDVGKLKYLGH
ALHETERLHPVAFTMARTAAEAFEYAGYRIPEGAMLMISPAVTHRLPGLYPEPDRFRPER
FQDNPKDTRYLVGFGGGVHRCLGVHFAYLEMTIALAHLFREFEFELLDTNPRPVPGAHTK
WPRSPCRVRYVRRAGTGRAA
CYP205A1 Chloroflexus aurantiacus
NZ_AAAH01000322 GenPept ZP_00019057.1
1835..3214 gene="Chlo2055"
41% to 197A1 and 197B1
MIPAIPVLIGDTAMIRFPSPVAIRNLQQLRREPLTLLEELAARG
DVVPFRVGPQMMVLVNHPDLIREVLVTQHRSFVKGRVLERAKRLLGEGLLTSEGELHL
RQRRLMQPAFHRQRIAAYGDAMVAVAEARSARWQDGLVLDVSREFMAITLQIVGITLF
SADTEADADEVFAAMHDLVAMFDLAVLPFADWLFALPLPPVRRFQAVKARLDAIIYRL
IAQRRANPVDRGDLLSMLLTAVDHEGDGYRMTDTQLRDELLTIFLAGHETTANALTWA
LYLLAQYPSLAAHLAAELDTVLGGRKPTVADLPKLTYTSWFFAEALRLYPPAWLIGRR
AIAPVTLGDVRIAPDTIVLLSPWLMHHDPRFFHEPYHCDPLRHTPEAQAQRPKFAFFP
FGGGPRTCIGEPFAWMEGILVLATLAQRWQFLPVADHPVVLQTGITLRPRYGMQLQLR
ERRTVLGAA
CYP205B1 Frankia sp. CcI3
YP_483539.1
ABD13810.1
not like alni P450s same as ABD13810
52% to CYP205B2 YP_001509421 EAN1pec
45% to CYP205A1 Chloroflexus aurantiacus
MSRAPHVRSVAAPPSTAKTSDIKTSDRVPGSGEGPVEAIRRLRADPLTRLNELARAHGPVVRLASWPVSA
FLVTDPDAIADALVSGHRAYAKGAVRRGAGSRRTVVQPLALLLGQGLLTSAGDTHRQQRRLLQPLFHKQR
IAGYADAFAAIADKTADGWRDGQRLDVHTEMTEMTLAIVARTLFDVDLDSHVVDVIRAALDQNMPAARRA
QLPGFTTLERLPLPAPRRRRDARNALDRVVHDLIADRRATGATGNDLLSLLLTARDADTGASMDDSQVRD
EALTLLLAGHETTANALTWTFHLLGRDPEVLATLQAELDRVLGERRPTIDDLPQLPYTNAVISEAMRLYP
PVWAMGRHLVEDRDVAGYRLPAGSTLVFSQWVVHRDERWWPRPELFDPIRWTGPDTADEPADAGPKMRPR
FAYFPFGAGPRQCIGNTFAITEGVLALAAIARRWSFTPVPGLPVTPQPLVTLRPKDGLPMIAHGRYPNR
CYP205B2 Frankia sp. EAN1pec
YP_001509421.1
ABW14515.1
42% to CYP205A1 Chloroflexus aurantiacus
MSIDRLPTAGHTGAQAPGPGRATPAFLRELLADPLRLFTRLRTSYGPIVRVPVGRGGFHLVCGPEAVEQV
LVGEQRAYAKGLRRRTMPPGEGIQPLSLLLGSGLLTSGGDLHRTRRRLIQPMFHRERIAGYGAAISELSR
ATALGWADGSRREVHTDMSELTLAIVARTVFGVDVDSEVVRRVRRAVAANMRLSQLAVLPGAIRLQQHLP
IGPLRAARDARDDLTAVVMEMIEQRRSLDAAGSDLLSTLLATRDADTGAPLDDTSIRDEALTILLAGHET
TANAMAWAYHLLATNPQARDRMHTELDDVLNGRKPTTADLAELPYTRAVFSETLRLYPPAWILLRRTTRD
VTLTGYHLPADTNVLLSQWVIHRDPTWWPAPEEFRPQRWLTPDPTRPKYAYFPFGGGTRQCIGNTFAEME
GALALAAISSIRTLTPTPGRPVTPIPRVTLRPQPLQMTAHPRTPHPTPATHQPH
CYP206A1 Agrobacterium tumefaciens (strain C58, Cereon)
GenPept H97549
NC_003062 1555403..1556797
34% to CYP173A1
1 MTEIGFRTPS TDTTGAQPVS KLATARLALS LIRNPLKALP PEIFSEPAVF TRLGGVMRVH
61 LADPVLIHEA LVKNAALLGK GEDVRRALGP ALGQGLLTAD GDHWKWQRQS VAAAFRHEKL
121 LELLPVMIET ARRTQKRWRS SSTADIDIGH EMMRTTFDII VETMMSGGYG IDIARVEQSI
181 TDYLKPTGWT FALAMLGAPE WLPHPGRRKS RAAVDYLRAS LATVITGRRK NPTDRPDLVS
241 MLLEAKDPET GRMMSDEEII DNLLTFITAG HETTALGLAW TFHLLSQNPE TERKAVEEIE
301 AVTGGEPVAA EHIANLAYVR QVFSEAMRLY PPAPVITRTA LQDFRLGEHD IPAGTVLYVP
361 IYAVHRHTAL WDEPERFDPS RFEPEKVKAR HRYAYMPFGA GPRVCIGNAF AMMEAVAILA
421 VILQKNHLEN RTMASAEPLM RVTLRPQERL MMKITQRQNK SPAV
CYP207A1 Kitasatospora griseola
GenPept BAB39208
GenEMBL AB048795 6250..7698
30% to 183A1
1 MKGNLPAMST ATSSSVTGSV TTPRTATTPG RRPGLAPGGV PVLGHLPMIL RSRFEFIETV
61 RNAGPVTRVK LGPKTAYFVN DYELLAQILV SDADKFVRGI HFKKMRNMVG NGVVTTSGDL
121 HRRQRRIMLP SFSQRRLAMH LPVMRKIMSE FVASVPERRP YDLMGPVMGV GCDIVTSTML
181 GEKTPPEVLR LVREAVPVFV ENAAIQAVDV TGIYKHLPTK SNRDFERLLN AFNEYMYSVI
241 DDKFRNGAGE EAGLLDMLIN ATDPETGEKF DRTEVRDQAA TILLASTETT ANTISWACYE
301 LARHPRIFAE CRAEIDALVK DRDWLDIEIG RHDLPALKRV LFEALRMYPS SYLLSRQASV
361 DTTLGGYAIP KDAAILYSHY GQQRDERNFP HGDEFDPDRW LDKDGAEVTA SAFMPFGFGA
421 YRCLGESVAV LEATYCLAMM VHQWDFALSD YSEPKMNATI TLSPKDLEFL FTKRTESGAH
481 DE
CYP208A1 Streptomyces globisporus
GenPept AAL06697
38% to 184A1
1 MRIDPPGPPL RALPGLLRKL AVDRLGMMRD AAGLGDAVRV SMGPKKLYIF NRPDYAKHVL
61 ADNSDNYHKG IGLVQSRRVL GDGLLTSDGE TWREQRRIVQ PAFKPGRINQ QAAAVAEEAA
121 KLVALLRGHE GGGPVDVLQE VTGLTLGVLG RTLLDSNLTA HESLAHSFEE VQDQAMLEMV
181 SQGTVPAWLP LPPQARFRRA RRELYRVADL LVADRRSRMA DGGPGDDALS RIIVAADRRR
241 DDPARARNRL REELVTLLLA GHETTASTLG WTLHLLERHP EVRDRVRAEA RAALGDGVPG
301 PEDLHRLTYT TMVVQEAMRL FPPVWILPRV AQQRDVVGGY TVSAGSDVLV CPYIMHRHPG
361 LWEDPERFDP ERFEPRQTAD RPRYAYIPFG AGPRFCVGSN LGMMEAVFVT ALVTRDLDLR
421 TVAGHRAVAE PMLSLRMRGG LPMTVSTAR
CYP208A2 Streptomyces carzinostaticus subsp. neocarzinostaticus
GenEMBL AY117439
complement(50199..51551)
70% to 208A1
MNGRRPVSPPLRALPGLLRKLAVDRLGMMRDAAALDDAVLVSMG
PKKLFVFNRPDYAKHVLADNAANYRKGIGLIESRKMLGDGLLTSEGELWREQRRTVQP
AFRPARVAAQADAVAEETMNLRDLLMRRGADGPVDVLQEVTGFTLGVLGRTVLNTDLG
GYGGIAHAFEAVQDQAMFDMVTQNMVPTWAPLATQRRFRRARRELIRTVDELVADRSA
RMTDGEEADDAFSLMIAAARRQTDPRTGQGRLRDELVTLLLAGHETTASTLAWTLLLL
ARHPHMRDLVREEARGVLADGRAPDAGDLRKLTYTTQVVQEAMRLYPPVWILPRVARQ
SDEVGPYSVSAGADVLICPYTLHRHPDLWERPEQFDPGRFDPARVADRPRYAYIPFGA
GPRFCVGSNLGMMEAVFVTALLTRDLVLEVVPGDERTPEPMMSLRMRGGLPMTVRPVR
CYP208A3 Actinomadura madurae
GenEMBL AY271660 10415..>11426
maduropeptin biosynthesis gene cluster
partial sequence RUNS OFF END
69% TO 208A1
gene = madE7
MSIDELDARGGTPRAAGRVPPGPPRRATPNLLRMLATDRLGMMQ
AALRHGDAVRVGLGPKALYLFNRPEHAKHVLADNSGNYHKGIGLVQARRALGDGLLTS
EGDLWREQRRVVQPAFQHKRIAGLADAVVEEAGALVARLRARAGGPPVDVVGEMTALT
LGVLGRTLLDADLTAHTSLGRAFETVQDQAMFEMVSQGMVPMWLPLPGQLRFRRARRE
LDRIVRALVAERLREGGGAEDALSRLIESARREPDGRVGRRRLRDELVTLLLAGHETT
ASTLGWTFHLLDRHPLVRARVRAEARAVFGDGTPTLDDLSALSYTTMVVQEVMRMYPPVWI
CYP208A4 Salinispora tropica (marine actinomycete)
Strop_2694 complement(3029601..3030959)
62% to CYP208A1 Streptomyces globisporus
67% to CYP208A3 Actinomadura madurae
MTVAAAGRTFSGPTGAALLRSLWQLGQDRLGLMTSAARYGDAVRLGVGSRSLYFFNHPDH
AKHVLADNSGNYTKGLGLVHARRALGDGLLTSEGELWREQRRVIQPVFQAKRVAGQAHAV
AEEADRLIARLRARRGRGPVNLTDEFTALTLGVLGRTLLDANLDAFTTVGAAFEEMQNQA
MFEMASMSMVPMWVPLPQQLRFRRARRELERIVGRLVADRTARGEGTGADDALSRLIAST
RDEPDPGVARRRMRDELVTLLLAGHETTASTLGWTFHLINQDPRVRVRLREEAIDVLGGR
LPEYADLARLTYTKMVVSEAMRLYPPVWMLSRLARDADVVDGYPVPARADVLICPYTLHR
HPAFWPEPERFDPERFDPEVTTDRPRYAYVPFGAGPRFCVGNHLGLMEAVFVVAMVSREF
DLVAPVGQPVVAEPMLSLRVRGGLSMTVEPVS
CYP208A5 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR611
84% to CYP208A1
CYP209A1 Myxococcus xanthus
GenPept CAB40542
38% to 110D2
1 MGTSEPVEPD HALSKPPPVA PVGAQALPRG PAMPGIAQLM MLFLRPTEFL DRCAARYGDT
61 FTLKIPGTPP FIQTSDPALI EVIFKGDPDL FLGGKANNGL KPVVGENSLL VLDGKRHRRD
121 RKLIMPTFLG ERMHAYGSVI RDIVNAALDR WPVGKPFAVH EETQQIMLEV ILRVIFGLED
181 ARTIAQFRHH VHQVLKLALF LFPNGEGKPA AEGFARAVGK AFPSLDVFAS LKAIDDIIYQ
241 EIQDRRSQDI SGRQDVLSLM MQSHYDDGSV MTPQELRDEL MTLLMAGHET SATIAAWCVY
301 HLCRHPDAMG KLREEIAAHT VDGVLPLAKI NELKFLDAVV KETMRITPVF SLVARVLKEP
361 QTIGGTTYPA NVVLSPNIYG THHRADLWGD PKVFRPERFL EERVNPFHYF PFGGGIRKCI
421 GTSFAYYEMK IFVSETVRRM RFDTRPGYHA KVVRRSNTLA PSQGVPIIVE SRLPS
CYP210A1 Polyangium cellulosum = Sorangium cellulosum
GenPept CAD43453
spiL biosynthesis of spirangiene
40% to 110E2
1 MISISKSKQK LLPPGPRSPM ALQTLQWLKN PVPFLEACGA RYGEMFTLKL PTQWPVVVVQ
61 HPEAVKEVFA LDSNAGHAGE ANNILKPFLG KYSLLVLDGE EHMRQRKMMM PAFHGERMEA
121 YGHAMIDAAH ASIDAWPVGS PFGVHAPMQA ITLQVILRTV VGMTDGPLLA ELEALYPQVI
181 DAASAPAMHF ELFRKDLGPW SPWGKFKRRS ARGKEIMIHE IRRAREKGTA GRTDVLAMII
241 DAKDENGELL TEDEIHGELM TLLVAGHETT ATALCWALRW LLRDAALTRR VAEEAAEVAD
301 DPVKIAKSEL LDRVVKEALR LQPIGPVVAR VLKQPLTIQG RELPADVMVA PCVQLLHHRP
361 SLYPEPTRFD PDRYATFTPK PWEFIPFGGG LRKCIGAAFS MYEMKMVLAT AFSRLSMELA
421 TDDIKIIRRG VTLAPSGGLP LVIRKKSPRA TKPIAA
CYP211A1 Streptomyces globisporus
GenEMBL AY048670
47223..48479 ORF29
39% to 107L1
MAGLVMSPVEALDALGTVQGRQDPYPFYEAIRAHGQAVPTKPGR
FVVVGHDACDRALREPALRVQDARSYDVVFPSWRSHSSVRGFTSSMLYSNPPDHGRLR
QVVSFAFTPPKVRRMHGVIEDMTDRLLDRMARLGSGGSPVDLIAEFAARLPVAVISEM
IGFPAKDQVWFRDMASRVAVATDGFTDPGALTGADAAMDEMSAYFDDLLDRRRRTPAD
DLVTLLAEAHDGSPGRLDHDELMGTMMVLLTAGFETTSFLIGHGAMIALEQRAHAARL
RAEPDFADGYVEEILRFEPPVHVTSRWAAEDLDLLGLSVPAGSKLVLILAAANRDPGR
YPEPGRFDPDRYAPRPGGPEATRPLSFGAGGHFCLGAPLARLEARIALPRLLRRFPDL
AVSEPPVYRDRWVVRGLETFPVTLGS
CYP211B1 Salinispora tropica (marine actinomycete)
Strop_1867 2135609..2136880,
45% to CYP211A1 Streptomyces globisporus,
45% to CYP107AE1 Streptomyces sp.
44% to 107L2, 45% to CYP107AZ1, 42% to Strop_2480
note CYP211 is quite close to CYP107
MDASEAVALLMSPLGRIDPYPTYERLRAHGPVVQTAAGFFVVTGYTEADTVLRNARLAFE
VMDDELRDDVFPHWQDSPAMKSIARSMIRANPPNHGRMRRLAAGAFTPRRIAALREVVTA
QADELADEMIRAGRDGAPVDFMGSFAYPLPVAVICALLGVPAADWARFRGWASDLTAVLE
PEITPQELTVADAGASELRDYFTELIAQRRRAPADDLTTALVQTHDADGDRLSGEELLAN
LVLLLVAGFETTTNLLGNGLVVLLAHPDSATALRDQPELAPGHVDELLRYDSPVQLTTRT
VRESVLLAGVELPAGSWVLVLLGAANRDPERFTDPTRFDPGRAQSPPLSFGAGAHYCLGA
GLARLEAQVAFPLLLRRLPELALAGEPTRRNRLTLRGYETLPVTVSAIAADHGTPAGVAR
GTP
CYP211C1 Salinispora tropica (marine actinomycete)
Strop_2480 complement(2788560..2789786)
41% to CYP211A1 Streptomyces globisporus
39% to CYP107L1 AF087022 Streptomyces venezuelae
42% to CYP211B1
note CYP211 is quite close to CYP107
MLDVEGLLTRLYSEQGRQDPYPVYAGLHAQGAIAALAPRPEGQRVAAVAVGYDLVGAVLR
DPEWSKQPPPGWMEQEILRTLQSSMMFINPPDHGRMRKVFAGTFTPRRLGTLEPVINRVA
DELLDRMADAGPGEVDFVAEFAYPLPARVMAEFIGIPATELAWYRDRVDRIDAFLDVAGK
TPERLAAANAAAAELRVFYADLLARRRRTPGEDLISGLVEAVDAGGVQLTEDELINNLIV
LFNASFVTTVYMLSNGLPVLLEHPEVAAALADDPELTAGAIDEILRLQTPVHLLARAAPR
DTVLGGVPIPQGQNVLLLIAAANRDPAHFPDPDRFDPRRPGPPSLAFGLGLHYCLGAAVS
RLEGRLALPRLLSRFPRLRIMEQPVYSGSLFLRGIDKLSVSPGGRMHP
CYP211D1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE2708 46% to CYP211B1
CYP211E1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY1166 40% to CYP211A1
Formerly CYP211D1 but not orthologous
CYP212A1 Chromobacterium violaceum ATCC 12472
GenEMBL AE016919 complement(139513..140919)
NC_005085 complement(2867614..2869020)
locus_tag = CV2656
57% to 2A12A2 33% to 205A1
MKTPPQSSCPFHAVGRPPTPPRSSAGRWPPGPESGLTGWGLLKL
MSRDLMGTLAGWQREFGDLVHVRTWPEHQVIVSDPQLARELLVNQADALQRWERALTV
YRRVHGHSVLIAEGQVWREKRQALQPDFTRKSVQAFSPSIVEAARRAFEQWPARHAAW
PIESELTSVTMEVILRMMFSSGVGSEAQQAEEAVHTLMVASTEELWRPASLPDWVPWQ
RKRRRARLLMNGLIERHLQARLAMPQDAWPEDLLSRLLRLHLQQPQSWPLQAVRDECK
TAFLAGHETVATSLTWWAWCMASHPEIQERAREEALAALSGGGQADPAALQYVSQTLL
ETMRLYPAVPLLMSRRALKPVTLGDWTFPAKTVFMVPMQLMQHDERWFPEPRSYRPER
FGPDAARPQQGAYLPFGGGPRVCLGQHLAMAEMALVAAQLLLRYRLSAPEGAEPPRPV
FHVSQRPSQPLTLGIARI
CYP212A2 Ralstonia metallidurans
GenEMBL NZ_AAAI01000313
14554..16035 gene = Reut2995
57% to 2A12A1 32% to 197B1
MTVDVVSIQDSPRGSVWNLHMTTESQAQCPFQTAKSPPPAGSPL
PHPYGTWPPGPAAGLTGWHLLRRMSRDLLGTLGEWQQTYGDVVHLRMWPEHAVVVTDP
QLVRELLVTHHDSLIRWERGTRVFSRVHGHSVLTAEGDAWSRKRQALQPGFMPKAVHG
FVPGIVEIVDKGLATWPTRVADWPVESALTSLTMDVIVRMMFSDEIGEDARVAECAVR
AISEAANADFYWPASLPDWVPWKRARRRALHTLRDLIERHLQARLRMRTDTWPDDLLS
RLLCLHRDDATAWPLQAVRDECMTTFLAGHETTAATLTWWAWCMASNPSAQDAARAEV
THVLRGQAPTADSRQALRQVVQTITESMRLYPVAPVLISRRAVRPITLGPWRLPARTL
FMLPLQLMHHDPRLFPEPERFQPDRFSTGSPQAPRGAYMPFGTGPRVCLGQHLATAEM
TVIAAMLLQRYKLSVPEGAAHPRPLLNVTLRPDQPLWLAVTPI
CYP213A1 Synechococcus sp. WH 8102
GenEMBL AABA02000001 or GenEMBL BX569692 335184..336428
63% to 213A2 31% to 120A1
1370816 MTAAPLPSTGAVTGLGETLAFFRDPSFSQRRFSELGDVFETKLLAQSIV
FIRGERAIGDLLKQEDCLQGWWPDS
1381038 VRQLLGSKSLANRSGADHKARRRVVGQLFSSAALS
RYTPAIEALVNDLANELQQAEGPIPLAARMRRFAFSVIA
TTVLGLEAENRDALFADFEIWTRALFSIPLALP 1381358
1381359 GTPFARALAARQRLLARLKTVLQTNNNRQQGGLDLLSGGLDEAGLPLDDDDLVEQ 1381523
1381524 LLLLLFAGYETTASSLSCLFRALLLNPEVEQWLMQDLNNHERPSRLDATVL 1381676
1381677 EVMRMTPPVGGFFRQNTQSIELADVAIPQGRVIQVVLSSSSTTNQIDLETFRPQRHL 1381847
1381848 DGSFQQTLLPFGGGERVCLGKALAELEIRLMAMGLLQRVQLHL 1381976
EPDQDLNLQLIPSPTPRDGLLVRATAR* 1382160
CYP213A2 Prochlorococcus marinus str. MIT 9313
GenEMBL AAAZ02000001
63% to 213A1 35% to 120A1
1661568 MASSDDAKLRPLPNTAALSGVLEAFAFFRDPAFAQKRFERHGNVFETSLLGQPMVFIQGGQAIRDLLA 1661771
1661772 QPNAVEGWWPESVRQLLGSHSLANRNGASHRARRRVIGQLFSASALQRYSAGIISMVQ 1661945
1661946 DLADELQAAKTALPLAERMRRFAFSVIATTVLGLEGTDRDELFVDFEIWT 1662095
1662096 RALFSIPIALPGSSFAKALKARERLLRRLQKVLLKASNGNGGLDLLAGGLDE 1662251
1662252 AGIPLTDEDMVEQLLLLLFAGYETTASSLSCLMRELLLNPQVETWLREEINGVDWPPAPE 1662431
1662432 QATTAYDQVNAPKLDAVVSEVMRLTPAVGGFFRRTKCALVIDGVEVPKNRVVQVALA 1662602
1662603 ASNRHGAGDLEAFRPQRHLEDGCSATLLPFGGGERVCLGKPLAELEIRLMVVGLFHQLR 1662779
1662780 LHLIPDQDLTLQMLPSPTPRDGLLTKVL* 1662866
CYP213A3 Prochlorococcus marinus str. MIT 9303
YP_001016373
MASSDDAKLRPLPNTAALSGVLEAFAFFRDPAFAQKRFKRHGNVFETSLLGQPMVFIQGGQAISDLLAQP
NAVEGWWPESVRKLLGSHSLANRNGASHRARRRVIGQLFSASALQRYSAGIISMVKDLADELQAATTALP
LAERMRRFAFSVIATTVLGLEGTDRDELFVDFEIWTRALFSIPIALPGSSFAKALKARERLLKRLQKVLL
KASNGNGGLDLLAGGLDEAGIPLTDEDVVEQLLLLLFAGYETTASSLSCLMRELLLNPQVETWLREEIDG
LDWPPAPEQATTAYDQVNAPKLDAVVSEIMRLTPAVGGFFRRTKCALVIDGVEVPKNRVVQVALAASNRH
GAGDLEAFRPQRHLDDGCSATLLPFGGGERVCLGKPLAELEIRLMVVGLFHQLRLHLIPDQDLTLQMLPS
PTPRDGLLTKVL
CYP213A4 Synechococcus sp. CC9605
YP_381833
MATTPLPSTGALSGLGETLAFFTQADFAQRRFETHGDVFETKLLAQRMVFIRGERAIGDMLGQGDALQGW
WPESVRQLLGSRSLANRSGPGHKARRRVVGQLFSSAALARYTPSIEQLVAELCHELITTNTALPLAARMR
RFAFAVIATTVLGLDGASRDALFADFEIWTRALFSIPLAIPGTPFAKAMAARQRLLKRIKGVLQAGTNQG
GLDLLSGGLDEAGIPLDDDDLAEQLLLLLFAGYETTASSLSCLFRALLLNPEVESWLRDGLNKDPASPKL
DATVMEVMRLTPPVGGFFRRSLAPIELAGVAVPEGSVIQVVLSPTSDGDDDDLASFRPQRHLDGSFKQTL
LPFGGGERVCLGKALAELEIRLMAVGLLQAVELQLQPGQDLALQLIPSPTPKDGLLVQAAAR
CYP213A5 Synechococcus sp. RCC307
YP_001227362
MSASAEQAESITCSLARSGSMPAKPLPNTGALSGLKETLDFFGDPGFAQRRFETYGDVFATKLLAQPIVF
IRGERAINDLFSQSDSLEGWWPESVKKLLGSRSLANRSGAGHKARRRVVGQLFSSAALARYTPSIIGLVD
ELADELINADGPVSLAGRMRRFAFAVIATTVLGLDSESREALFADFEIWTKALFSIPLAIPGTPFAKAMG
ARQRLLNRIKAVLQEGSNQGGLDLISGGLDEAGIPLDDDDLAEQLLLLLFAGYETTASSLSCLFRALLLH
PEVMEWLSSDVMASPWPAATSPQSEKLDATVLEVMRQTPPVGGFFRRSKQAIELADVAVPENSVIQVALT
PTAATSGTDLSEFRPQRHLDGSFEQTLLPFGGGERVCLGKALAELEIRLMAVGLLQKVQLQLVPDQDLAL
QLVPSPTPRSGLMVTATER
CYP213A6 Synechococcus sp. WH 780
YP_001224729 3
MVTFVLPCVMAAKTLPSTGAVTGIKETLDFFGDPQFAQKRFKAHGDVFETRLLNQRLVFIRGEQTMADLF
AQGDALEGWWPESVRQLLGSRSLANRSGDGHKARRRVVGQLFSAAALSRYTPSIAALVEELADELIQAKA
PVQLVPCMRRFAFAVIATTVLGLDASDRQALFADFEIWTRALFSIPVAIPGTPFAKALEAKKRLLGRLKQ
VVAQTSAERGGLDLLSGGLDEAGIPLTDDDLVEQLLLLLFAGYETTASSLSCLMRALLLNPEIEQWLLPE
LLDQPWPNLESRSCPRLDATVLEVMRLTPPVGGFFRRTKQTIQLAGVAVPPDRVIQVALAPDLGDGSCDL
AEIRPERHLDGSFTQTLLPFGGGGRVCLGKALAELEIRLMAIGLLQRVHLGLTPNQDLTLQQIPSPSPRG
GLLVTASARHKS
CYP213A7 Synechococcus sp. WH 7805
ZP_01123846
MTARSLPSTGAVTGLKETLDFFRDPQFAQKRFTAYGEVFETRLLNQRLVFIRGEQPIADLFAQGDALEGW
WPESVRQLLGNRSLANRSGEGHKARRRVVGQLFSAAALSRYTPSIAALVEELAEELIQAKAPVQLVPCMR
RFAFAVIATTVLGLDASDRQALFADFEIWTRALFSIPVAIPGTPFAKALEAKKRLLLRLQQVLAQTSTRR
GGLDLLSGGLDEAGIPLTDDDLVEQLLLLLFAGYETTASSLSCLMRALLLNPEVEQWLLPELLDQSWPNL
DARSCPRLDATVLEVMRLTPPVGGFFRRTKDTVQLGGVAIPPNRVIQVALSPDLGDGSCDLADIRPQRHL
DGSFTATLLPFGGGERVCLGKALAELEIRLMAVGLLQRVRLELTPDQDLTLQQIPSPSPRGGLLVRASAR
DTSR
CYP213A8 Synechococcus sp. CC9311
YP_730662
MMAHAHLPTTGALTGVFESLAFFRDPSFAKRRFRAHGDVFETCLLGQRIVFIQGDQPIADLLAQGGCLEG
WWPKSVQLLLGSRSLANRNGDGHKVRRRVVGQLFSSAALRRYTPEISVLVQKLVDELLNSTSPQPLAPRM
RRFAFSVIANVVLGLDDRNRDECFADFEIWTKALFSIPISIPGTPFAQAMNARTRLLTRFKQLLANDTPL
RGGLDLLRAGVDESGISLDDDDLAEQLLLLLFAGYETTASSLSCLFRALLIDPTVNTWLLSELDAKSAQD
DLDRSLPRLDATVLEVMRLTPPVGGFFRRTKAPVILSGIEVSADRVIQVVLTPSSPSDDSDFFDFRPQRH
LDGSFHQTLLPFGGGERVCLGKALADLEIRLMALGVLKNIELQLHPNQDLSLQQIPSPTPRDGLVITSQR
RLE
CYP213A9 Synechococcus sp. CC9902
YP_376971
MSRPLPSTGAVTGIVEAINFFRDPDFATRRFTEFGDIFETSLIGQRLVFIRGDKAIADLLAQGDAVEGWW
PESVRQLLGSQSLANRNGSDHKARRRVVGQLFSSAALKRYTPGMIGLVDELSQELLEETKPIRLADRMRR
FAFRVIATTVLGLEGSDRDALFHDFEIWTQALFSVPIAIPGTPFANALAARRRLLDRLRDVLEQADQNRG
GLDLLAGGLDEAGQPLTADDIVEQLLLLLFAGYETTASSLSCLMRACLIEPHVEPWLREELDGLEWPPQG
DATTAFDGNRAPRLQAVVTEVMRMTPPVGGFFRRTCRPIELANILIPKGHVVQVALASSNRAGSSELNEF
RPQRHLDGSNKPTLLPFGGGERVCLGKALAELEIRLMVVGLLKRVQLSLAGDQDLDLQLIPSPSPKDGLK
VVAKHYAPADAKA
CYP213A10 Synechococcus sp. BL107
ZP_01468069
MSRLLPSTGAVTGILEAIGFFRDPDFATKRFVEYGDIFETTLIGQRLVFIRGDEAIADLLAQGDAVEGWW
PASVRQLLGSQSLANRNGSEHKARRRVVSQLFSNAALKRYTPGIVGLVDELSHELLQETKPIRLADRMRR
FAFRVIATTVLGLEGSDRDALFHDFEIWTQALFSVPIAIPGTPFANALAARRRLLDRLREVLEQADQNRG
GLDLLAGGLDEAGQPLTADDIVEQLLLLLFAGYETTASSLSCLMRACLIEPHVEPWLREELEGLEWPAQG
DATTAFDGLRAPRLQAVVNEVMRLTPPVGGFFRRTCRPIELANVLIPKGHVVQVALAASNRAGSSDLNEF
RPQRHLDGSNNPTLLPFGGGDRVCLGKALAELEIRLMVVGLLKRVQLSLAVDQDLDLQLIPSPSPKDGLK
VVARHYAPDDARG
CYP213A11 Synechococcus sp. RS9916
ZP_01472377
MTRSPSARPLPTTGAITGVGEAIAFFRNADFAQQRFERLGDVFETKLIGQRLVFIRGDAAISDLLGQAEA
VEGWWPESVRRLLGSRSLANRNGAAHKARRRVVGQLFSSAALQRYSPRIVEQVNALAQDLLNSTHTPIPL
AERMRRFAFSVIASTVLGLDDNDRDALFGDFEIWTRALFSVPLAIPGTAFAKALAARERLLIRLKEVLAK
ADGSRGGLDLMTGGLDEAGLPLSDDDLVEQLLLLLFAGYETTASSLSCLMRELLLQPTVDQWLREETNAL
AWPPHDAEAAMAYDSQRAPRLNAVVQEVMRMTPPVGGFFRRTTGAVTLAGVEVPAGSVIQVALAASNRHG
AGDLDAFRPSRHLEPGNGGPTLMPFGGGERVCLGKALAELEIRLMVVGLLQQVDLELTPDQDVSLQLIPS
PTPRDGLRVRATADHERHPSLKTD
CYP213A12 Synechococcus sp. WH 5701
ZP_01086392
MSGVLETLAFFRDPDFARSRFERYGDVYETTLLGQRTVFIRGGQAVGDLFAQGDAVQGWWPDSVRKLLGP
LSLANRNGVDHKARRRVVGQLFTTVALKRYSPAIVALVNELSHDLLGCAAPVALVPRLRRFAFSVIASTV
LGLDPVDRDALFVDFETWCQGLFSLPFALPGSPYARARQARGRLLLRLGSVLNKAQAAVAAGKPLAAGGL
DLLAGGLDEAGLPLADDDVAEQLLLLLFAGYETTASSLSCLLQTLLQHPAELAWLQQELGALSWPPPQGE
ATTAYDAIRAPRLDAVVKEVMRLTPPVGGFFRRTLEPIALAGVLVPADRVVQVSIAASHRHGREDEDLEV
FRPQRHLAGDSTATLLPYGGGERVCLGKSLAELEIRLLTVGMLKQLMLVLKPDQDLTLRVIPSPSPTDGL
LVRPLPRATGLHSPVR
CYP214A1 Trichodesmium erythraeum IMS101
GenEMBL NZ_AABK02000024
74165..75511 gene = Tery2345
36% to 120A1
MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVY
QKYGPVYKTNFLGKNFIYFQGYEAIKFILTNENKYFTYSQILRNYQRIFGENDITVLA
GKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKWIKSDYVDLYSEINNYTLDMI
LKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFNQFEQIIVR
RKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTS
EHLDVLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDC
SFQGFRIPKGWHAYYYISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGG
ARECIGKEFAYLVIKIFISALLDNCSWKFKENQDLTINTFPVARPAHKIEVCFTPK
CYP215A1 Thermobifida fusca
GenEMBL AAAQ01000026
complement(53223-54434)
35% to 127A3
MPAPIRIQQCPVSHTDFSTDTEIYG
HYAMLDAEREASRFRFNDTTDRGFLMIQRYDDVVEGFQHHETWTTKVRSAINPDSRSGTA
LLPQDLNGEAHAKLRRVLNPFFSPAAVRRMEPMAVARCIELIEELQPKGSCDFVAEFAIR
YPTDLFLALLGLPVSDGEFFLPWSETVFAGFFGEDPAKVAEARKNIIDYFTETIRERRAN
PRDPKEDMVTRLLEARIDGTPIPEEDILTICLTLMLAGLDTTRSALGYIYAHLARNDADR
QAIIDNPDLVPRAVEEFLRMYPLVFQVGREVQEPTEFHGLDLQPGDVVWLGIAQANRDPR
KFPEPDRFNPDRKGVNQHIAFGAGPHRCLGMHLARLELAIVLREWHQRIPHYRIREGVTL
TERGGQLTLPTLPLEWEA*
CYP216A1 Thermobifida fusca
GenEMBL NZ_AAAQ01000039a
98411..99769 gene = Tfus2242
37% to NZ_AAAQ01000042 Thermobifida fusca
39% to 157B1
MTRSPSPPIRLYQAADPTALWPALLAEYGEIAPVELEPGINGWL
LLSWRLNREVMRDAETYARDPDRWADMANGRIGPRSPLRVLYGKYQSALYSDGADHKR
YRAALTAALDSLSLRQVTGHITAAADQLIDAFCLHGKADLVTQYTRQLTVTVLARLFG
LGPAETMRICLEMQAMWDEGPNAFPALMRIAEMLTELARKRRRTPGKDLASVLVAQGL
SDVEVRDNLLLIIAAADDPVTHLTGNTIRMLLTTPESRAALTTSPGLISEAVNTALWT
TPPLQTLVGRYPVRDVELAGVPIRAGECLVLGFAAASLDLAQHSDADTMSTNRAHLTW
GVGPHSCPLRGQDMALAIAETAVERLLRRLPDVALAVPPEQLRWRPSLAVRGLESLPV
RFTPTPVSNPGGTEWDSPADPTPSTSIRPKESTSPRSDANSSTKARWYAWLFPGTWKS
GL
CYP217A1 Thermobifida fusca
GenEMBL NZ_AAAQ01000029b
complement(46399..47577) gene = Tfus0917
39% to 145A1
MTTLAPSTDLDFYSEEVILNPYDTYRRLRDTAPAVWLERYQVWA
VTRYDDVYAALHDHRTFASGYGVALNDPLNEKMKGSALVSDPPYHDHVRGVMGGPLTP
RALRKHHDYFQERADALIDHLLELGRFDGVRDFAQIFPLSVVPDLLGWPAEGREHFLD
WASAGFQALGPMNERALRDLPTLKGMWEYMAEIVRPGRLAPGSWGAALVEAAEKGEVD
KQLLPALIGDYLVPSLDTTVSALSTMLWQLGENPDQWRMVREDPSLIPNVLNESIRYE
APIRALSRYVTEDTEIGGIPLARGSRALMVYASANRDERHRKDPDTFDVTRSNANTHV
GFGHGIHGCVGQGLARLEGHSLLNALVRKVARIEVGQPTWRVHNTIRAMTTLPVEFSA
CYP218A1 Thermobifida fusca
GenEMBL NZ_AAAQ01000042b
complement(348226..349737) gene = Tfus3015
35% to 156B1
MILNCEHDPVFHVPVVSTPGRWSVTHPLYPVGNSDTPHDRNAGS
SEGCPVSLDDREALHRLAVPVYGELDADLPDVLERLRKQFGRIAPVEVAPGVAAWILL
GYDVNRRVLQDSAEFARDPRRWREAREGRATPEKVPGPFWYFRNALASDDPDHSRYRP
VIVDALSGITADGTRLAVRRIATELLAPVALTGKADLVADFAFRVPLLVLNRYFGLSA
EEGLELVELMRQVWDGGEEAEKARLGLFAYAQSVTARRRENPGSDIVSRMVRHPNALD
DEEIAHQLILLISAAHDPLMNLIANTAHTLLTDEEVRYDLAGAHLRVEEVVDTVLWRS
PPITLLPGRYPVRDTLLEGAYVQEGDCLIIGYGPAHADPAVAPYIDPLSPSGIRGHLA
WGTGPHACPAQRISRQIAVDAVSALLDLLPDVRLAVPPESLERRRSLFAHGLKALPVT
FTPVDITPPTEAPWQQSQNPSSSSQENPASKPSSSVKRGRLPEWWSKVWKFGR
CYP219A1 Novosphingobium aromaticivorans
GenEMBL NZ_AAAV01000054
complement(4309..5553) gene = Saro0307
41% to 107AA1
MEAEAAIPPLDTSDPALIPDPWPTFTTLRERDPFHWSKYGYWVV
SRHEHVRDVLMNRKDFGTGDFAANLRLFYGPDFDVLANPAYRWLSEVFIMQDPPQHTR
IRNLVVGSLTAKRVRAMEPRIREIAQALTDGFKARGSADLITEFAYKFPVMVICDLMG
IDYEASEMADLIAAIPEAFTVFEARILSPEELALANRRILELEAFFQAQFENRLAHPR
GDLLTSLARTGQEPGGLSVHEAITVTIGLFGAGFETTANIIGNGLHALHANPEQWARL
VADPSGMASGACEEALRHQSSLIATYRTALADTSVCGHPVSAGQRVLTLIGAANRDPR
KFADPDRFDIARNDADHLTFGGGIHFCVGAELARIEARVAFEHLARELPQMQVDTGGA
CWRENFLFRGLTGLEARWPAQA
CYP220A1 Burkholderia fungorum
GenEMBL NZ_AAAJ02000117
18981..20198 gene = Bcep1617
35% to 107B1
MTFIYDPNDPDVRRDPHAVFRKLRETEPVHWSPKLSGWVVTSYE
LASEVLTTNGTYSAERFTAVQQHLSEEKRVTAAEVMRWFQHWMVFRDPPDHTRLRRHM
ANTLNIPVFDARRETVISVVNELLDRIPVGDAFDFFQAFSLWMPGIVVADLLGVERDR
LLEVKQWSDDMMTFIGSARGVPDKYERARRGANGMGTYFLDLIAKRRAEPREDALSRL
IASEVEGQRLSDDELVGCMMMVLNGGHETTANLLNNSMLALAAHPQTVQHLRQHPDEM
AAAVEEFLRYDSPVLSIGRIVTEDTELGDQEIAAGDRVFAMLVGANRDPEVFSDPDEL
RTSRNPNPHMAFGKGPHFCLGTPLARLEGQIALTAILERFSSIELCEPVESIPWLNSL
VTHGPTRLPLRLK
CYP221A1 Pseudomonas fluorescens PfO-1
GenEMBL NZ_AAAT02000002
complement(179015..181831) gene = Pflu5298
36% to 107B1
N-term is 38% to acyl CoA oxidase of Streptomyces coelicolor
MSDPLLKLLQKPLFDPEKRHRVSLREYMDLNIDRMRAIIGNGLM
TNAMWLSQPRQSEFRLMLERAALIGAVDYSLLACIVDHFIAGDAFFAHGSQHQIAQYH
QEICQLKAVYAFGCTEIASGSDVANLQTTINYDPHKHCLILNSPTPQSCKFWIGNALH
AAVVVMVLGRLIVKGVDEGLHWFRVRIREQENGPLLPGVRITTCDPKGGIHANQVAGI
RFCNMKLPLDALMQRYARFSAQGVFSSEIPPKERLKSAMQTFIQERLFLIAGARGAAS
MCVYLAYRFACHRLVKGNEGSQSLLTKALFRQRLYAEQLKVLALKLLEQAVLSRFEAC
WHQPARRKELHILAAVVKSVGTWLGLEVMSACRELCGSQGFHHHNRIVTLVMDHGIST
TFAGDNNILCCQVARDAINRPRFANENIAQRIESLIVDQCRRAGDFSHRQAVALTYAR
ALDLIINEGKHHPLVTSEIFEDIVHVFSPKLYEWELVASTKLEQNATEAQLILLNELL
KPPSELVRAPIDKKNYVKHF TKPLYDNKPDFSNRNTIRNPYRAYTWLRKHQPVYWCEH
LQAWFLTRYCDVIAAQADSRRFSSNRMQQLIDARVPENKRTHLNEFIKLASRWMYSQD
GDTHKASRHLLGNAFTPRSIEALRAIIQDITDRELSRLHGQTDLKTALFDRVPALILA
RLYGMKDDEALRLRRWTRDIVMFLGGSQDADQGPDQALEGIKEMYACFAELIEQRRRQ
PGDDLVSRVLESGQNSAASLDEVLAQIVFILVAGYTTSADQMCLGLLHLLKHPQQLEA
LLADPTLIGSFIEEMLRFDPAGSLSHRILMEDVTIDNITMKKGNLVYLIRASANRDPE
KFHAPNTFDIRRARNEHLTFGKGEHFCMGTSLFRLEAEIVFTSLLKRFPDLQLIARRP
AKWRNSNLQFRGLKTLPVDLGTGV
CYP222A1 Thermobifida fusca
GenEMBL NZ_AAAQ01000022.1
52729..54468 gene = Tfus0480
33% to CYP101
MSLRGLPGTAPRQRAGSPGPASFLKRRRDAAPRPTISLDGDGPL
RAGLGSIPGRRLQFGAHLFVEHVGVPVFFARRKHVGRGHVAHTVPLALLSVDSDAHVA
LLRDQRSLFSLAILTLMLLSITIITRTAIKITHHTRSRHRPYPHSSQRTSAHEPGQER
AHSMSNPTRCPVIHFDHHSPEHAKDPVGAYRALRQTHKRGWTEAHGGYWVLSDYQSVF
DAARDDDLFSSTREAAGTDGLAIVIPPTPMYHHIPIEVDPPEFRKYRKIVNQVTAPAA
VERMKEMVERYTVAFVDSVIEKGECDFTTIIGVPAIVTIDWLGLPVKDWKRYADAHRA
TLAEPQDSEAFRHAVEVELPALSQQMWDTIRARRQEPKDDVISFLVSQKVDDRPITDE
EVFAMVDLLVSGGTGTTASLVSQALVWLAKNPDVRQELIDDLSLLDRAVEEFLRVFSP
TQALARTVTRDVEFHGCSMKKGDRVLLSWASANRDEEQFENPDTIDIHRWPNRHVAFG
IGVHRCAGSHLGRFMAKRLLQEILTRMPDYTIDFDALVPFHDQGTNVGFRSIPAKFTP
GKRVLPLSEAVIG
CYP222B1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE9564 40% to CYP222A1
CYP223A1 Novosphingobium aromaticivorans
NZ_AAAV01000162.1
complement(33798..34988) gene = Saro2671
31% to 194A1
MHRAMTTTVQDFDPEVPEDFDSPHAEYARLRRECPVAHTNGLGG
FWALTRYEDVKRAASDSTTFITSVQNVVPKVAFTGRRPPLHLDPPEHTPYRKALNPLL
SLERSEAFAGKARELTRKLLAPMVENGGGDICVELSSYLPVHVFGEWMRMPEEWLDTL
HDAGRAFILAVHSNTPERMKETSLRLYDMARGLIAVRRENPQDPALDPTSALLAARHE
GEPLPEELLVGTVRQVLVVGMVAPMVMIGNICVHLSRDKALQQQLRADPSLVPAAIEE
FLRLYTPYRGFARTAVCDVDMGGRTIPKDEAIALVYASANRDEDVFPDGDKFILNRPN
IAQHLAFGRGPHNCPGVHLGRMQLRVALEEILAATREFELSGPVSVSRWPEVGALSVP
LRFV
CYP224A1 Novosphingobium aromaticivorans
NZ_AAAV01000154
complement(32211..33443) gene = Saro2336
36% to 127A2
MTLLFQPSPPDHVPGERMVDFDMFHVPEGQDDPVEIWHDLVRRG
VPRIFYTPRNGGHWVFLDYADIVEAYRDHTVFSTYQTPVPPIEPFPVVQPQGVDPPAH
NVFRRLLAPMFTPTAVRGMIGELERRASELIDRFAARGECDFITEFAERFPTSTFLHL
FGLPEEQLDAFLALANVFFRSTDAETRARNIGEIYAVLDTLFREKERNPGNDIASAIV
AARDEEGRQHPWEDILNCGFLLFVAGLDTVTNTMAYIWRYLATTPAARRHFRERLDDP
DAFLRAIEELMRINAVSNLFRRVTHDCEYKGVQLRRNDRVVLPNTVANRDPRVFSDPQ
AIDLDREVNVHLTFGVGPHRCIGSVLAKREVMVSLQQWLRRIPEFELAPEQPAGSAFG
GSVMGFTALRLRWVRVEA
CYP225A1 Novosphingobium aromaticivorans
NZ_AAAV01000151
17550..18872 gene = Saro2207
34% to CYP124
MPSPPRLAGTSTASGLEDQMQFPFSRSTNPNVDLSSLDAFNEGA
PFATFDRMRREDPMAWSEMVNGDRGFWSVTRHADLLELNRQADLLSSAKGIRMEDQTE
EEYEARKTFQETDAPHHRGFRALVSKAFSKGTVAGFEDQIRKIVTDLLDVALAEGEFD
AVDRIARRLPMQMLAQIMGVPQEDGPWLVEKGDALISNSDPDYTDFVVDQVDTEAYRM
LPFRSPAAVELFDYANGLLDRMDAGEQIGVLNLVREPTSTGTRMSRDEFRNFFCLLVA
AGNDTTRYSISATIHALANNPHLLQALKDGDFTSWEAAADEMIRYASPTTHFRRTATR
DFTFHDRHVKAGDKVLLWFISGNRDETAILDPYTINLRRERNPFLSFGQGGPHICLGM
WLAKLEVAIVMQELAKRLSSIEQVAEHSYLRSNFIHGIKHLPVRIVAR
CYP226A1 Burkholderia fungorum
NZ_AAAJ02000018
25472..26761 gene = Bcep5906
61% to 226A2 30% to 109B1
METGMTSPAKSNALESAFESTASNYRGSDVDLNAIYRDMRRNSP
VIAQDFMASLGVPNIAKLDPNRPTFTLFKYKDVMSVLRDAANFTSGFIAEGLGSFFDG
LILTGLDGEAHRRARALLQPVFLPEVVNRWRESKMEPIVRNEFIGPMVPQRRADLMHF
GLHFPIRLIYSLIGFADDRPEQVEQYAAWALAILAGPQVDAQKAAIARKAAMEAAEAL
YAAIRSEVAVVRAKGAEGEDLISRLIRAEYEGRRLDDHDIATFVRSLLPAAGETTTRT
FGSLMTLLLERPALLERVKADRSLVSKAIDEAVRFEPVATFKVRQAAVDTGIGGVSIP
KGAMVQCIVSSANRDEEVFENSETFDIDRKPKPSFGFGFGPHMCIGQFIAKVELQVAV
NAILDLLPNLRLDPDRSPPKIVGAQLRGPDAVHVVWD
CYP226A2 Burkholderia fungorum
NZ_AAAJ02000018
complement(62819..64102) gene = Bcep5938
61% to 226A1 32% to 107N1
MSTTLENPMLDLEAAYHAVSDTYRGPDIDLQALCREMRHKNPVM
KGDFVATHLGIPTNAGASAAKCEVTLFRYQDVLAVMRDATTFTNGFIAEGLGGFFDGL
IILAMDGDAHRRARGLLQPVFMPETVNRWRPELDRVIREDFLAPLVPNRHADLMDFGL
YFPIREMYALMGFPTDDTAKFNQYATWALAMVAGNQIDPGKIRIFGPIAAAAVKHLYD
AVMEVVLQRRAAGADGNDLISRLMRAEYEGHKLDDHEVTTFVRSLLPAAGETTTRTFS
SVITLLLERPALVERVRNDRSLIPRLIDEAVRYEPVATFKVRQAARDIEIGGVKVRSG
GLVQCMVMSANRDEDVFENADTFDIDRKPKPSFGFGFGAHMCIGQFVAKIELQCAVNA
ILDLFPNVRLDPARPAPKIAGAQLRGAKSVPVIWD
CYP226A3 Pseudomonas diterpeniphila
GenEMBL AF274704 7700..8974
P450 monooxygenase (tdtD) gene
72% TO 226A1 32% to 159A1
note="abietic acid metabolism"
MSGPAHSNLEQVFANVASNYRGADVDLHAVYREMREKSPVLPEN
FMARLGVPSIAGLDPNRPTFTLFKYDDVMAVMRDATNFTSGFIAEGLGSFFDGLILTA
MDGEAHKNIRSLLQPVFMPETVNRWKETKIDRVIREEYLRPMVASKRADIMEFALYFP
IRVIYSLIGFPEDRPEEIEQYAAWALAILAGPQVDPEKAAAARGAAMEAAQALYDVVK
VVVAQRRAEGATGDDLICRLIRAEYEGRSLDDHEITTFVRSLLPAASETTTRTFGTLM
TLLLERPELLARIREDRSLVGKAIDEAVRYEPVATFKVRQAAKDVEIRGVAIPKGAMV
SCIVTSANRDEDAFENADTFDIDRRAKPSFGFGFGPHMCIGQFVAKTEINCALNAILD
LMPNIRLDPDKPAPEIIGAQLRGPHHVHVIWD
CYP226B1 Mycobacterium marinum
No accession number
Tim Stinear
MM0272
40% to 226A3, 38% to 226A2, 37% to 226A1
CYP226B1P Mycobacterium ulcerans
No accession number
Tim Stinear
100% to 226B1 M. marinum in conserved region
CYP227A1 Nostoc punctiforme
GenEMBL NZ_AAAY02000109 21775..23139
very poor similarity to P450s
gene = Npun0867
MTVNIMTLKDKVLKGQDRQLWLAPILAKVGYDTAIGKFLRLIFY
YTDASIILKAWRDFLYIRKDNIGDKYFAVDQAIMHSSHSQVRELMQTQPQLRGNDLGI
IRILAPSYLLDNPLSLGTNGNEHTGLRTVILQALPEPSQKIDFLGNLVEQSLLEAAKQ
GKLHIGNDLPKIILSILHQLVFQISLSEEEITASDSYIKGLALASLPNFINKYLLAIL
TAPKIRHRQYLTNRYKQSAKWASYFETGAQYQLNEHQIANTLFDMIHIAGTAGTSALL
GSVIGVLCLDNDLRNDVVSEVNAVWNGKKTLDPDALEQLTILNQVILETARLYPPVRF
VSQLTNEGGEVEIGEQKCPFQKGTRLLGSIFTANRDANRYQNPNDFDLTRNFSDILSW
NGEGHERACPGKSLSIGFIKIFCLHLFQNYQWDSITEVKWDFEKVTAVTPNNLVLQGF
AQRL
CYP228A1 Magnetospirillum magnetotacticum
GenEMBL NZ_AAAP01002937 216..>1496
Gene = Magn3794
34% to 107N1
MGPRPHARLVRRPPLPARARGHPVTGTALAPAPAGLAAAMRWEE
RVQRGAHPLVYPAIRALRHRGPVVRVPGIGVVVSDAATARAVLLDTEHFSKVGPGSPS
DLWTPVLGPSVLLNMEGADHARLRRALSGLFTPRAVRDLVAVSVPDVLAGLAPRLLAG
ERVDLVAETATMAGTVVCAMTGLPPTDSAVREAMTAAQSVVGLVRLHRRSLTPSQVRH
ARAVLARLSAPARDAYRAGDPATVPGRMRELGLSEDEALGAVGAFVLTGTETIQSFVP
RLVALTADTGWLDRLLAADPGAGPEAAALRGRVVEEALRVTAPTPAMLRSVRAATTVG
DVRVRAGDRVVIATISCCKDAGPFDPDAPVDPAVRHLWFGAGPHFCLGMPLATAQVDA
VLDALRPVAAAGRSLQVTDRAVARGVLIPAYRSLV
CYP229A1 Pseudomonas fluorescens PfO-1
GenEMBL NZ_AAAT02000063 complement(5763..6863)
Gene = Pflu1316
MDPIIAATHADPYPYYAELRAAGGLTFHHGLKLWVASSARAVCA
VLAHPDCRVRPVQEPVPKAIVDGMAGKVFGLLMRMNDGEAQRCPRSAIEPPLGLIDRE
EVGALVSARLITNDSDGLYKAMFRGPVCVVASLLGFTPAQARVISELTADFAACLSPL
SNDLQLAAAHRAAEQLRGYFIEMLADPNPFLADIRQRFVGNEEVLLANLIGLCSQTFE
ATAGLIGNALVALHRQPELRNASVDSLLAEVQRFDPSVQNTRRFMANSCEIDGVRLEA
GDVILVLLASANRDPALNENPDRFRVDRPNRRSFTFGSGRHQCPGQTLAMTIASATLT
EILARNIDPGRFTWHYRPSLNGRVPMFSEVQP
CYP230A1 Pseudomonas fluorescens NCIMB
GenEMBL AF318063 58574..59938
mupirocin biosynthetic gene cluster.
Gene = mupO
MTSWEREVSRGAGNRQLPVVKGWPLLGSALALIRNPLGFLQTTR
STYGDVYRVKAAHMNFVVLAGMEANRFVADKGKDCFVSSGFWEATLQEMQCPHSFIGV
DGDAHRFQRNLMKPLFSKSAFNERIPMLAQIFTDTLQARYGVDQKVSALFRHVLSQQI
GGSLQGYQPTPDEVEALMRYQNTAMNVCALKKWPRLALRLPGYRAAKKQVQALADRII
ESERTQEQTQGYFQTLKEKGQMVQPQWFTPGDMRNHAIISYLAGIDTVGATLSFMLLE
LFKQPHLHQALRDEVDACFSQGLPDADGLENMETLKNFIREVMRLYPTAYAVRRTRRK
DFEFQGYSIDKGQDIILFTTANHTDPAWFKNPQVFDITRYEEPRLEHRASGAWAPFGR
GPHTCIGAGLANILLSLNLALFLYHTDLRPACKLSDIKMDFSNPAAGLSERFAISFTPRNRP
CYP231A1 Ferroplasma acidarmanus Archaea; Euryarchaeota
GenEMBL NZ_AABC02000007 complement(32352..33461)
Gene = Faci1014
38% to 109A1
MEHDVFQYYRKMRKESPVHFNNDTGSWDVFDYKSVYFVLMNPDI
YSSDPSYAGNIPENRQGPGASFITMDNPDHKELRNVTTPYFLTSKITGYRDMIESTSK
RLMEGINKNSDFIRDYAVMLPVTVISELLGVPENDRSKFKEWSDYIIGNRSDAGFQDL
NRYMYSTMAEIFKTNTEDNIISTINKGLFHSEPLSINQKIGYVMLLVIGGNETTTNLI
GNMVKVLSEHPEIADKLRQEPELKKGFIEETLRYYSPIQFLPHRFAARDSVLNGQEIK
KGQRLSIWLGSANRDGAKFEDPDTFNMERQNNDHLAFGMGIHMCLGSPLARLEAEIAL
NDILNKFKHVKINAEKTSMLKNPMVYGFSTMQLDD
CYP231A2 Picrophilus torridus, Archaea; Euryarchaeota
coded_by="complement(AE017261.1:1398572..1399603)
also YP_024177 in Entrez protein
Paul Ortiz de Montellano
Submitted to nomenclature committee May 25, 2006
Gene PTO1399
53% to 231A1
MRLNDPVHYDGAWHVYKYSDVKHVLMNDKIFSSNPGNRYSNAGG
ISFITMDNPEHKEFRDISAPYFLPSKINDYKDFIEETSNDLIKNIDNKDIISEYAVRL
PVNIISKILGIPDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHGII
NVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIIDDALKNR
SGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDL
FKIGRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMV
LGYDKLFLS
CYP232A1 Ferroplasma acidarmanus Archaea; Euryarchaeota
GenEMBL NZ_AABC02000015 12150..13295
42% to 109B1 40% to 119A1
gene = Faci0565
MEIPTYKEEPFEWYREMRKNSPVYREGNMIHIFKYNTISKILSD
HQNFSSQFRDLLGEEMAAMLNEKTTPSILLLDPPLHTTLRGLVGSAFTPRSIELFEPR
IREIARMLAHAIVEKENSDIVSDLSYQLPIRVISEMLGVPESDSEIFRDWSDKLATSL
GRGPDIETQYDMADYFYKKIDRNSKGNNLISRLSTVEMDGRKLSDKEIAGFAILLLVA
GNETTTNLITNAILSLYDHPEIYNEMRKTPSLIPGVVEETLRYRSPVQSTRRYSKIDT
EIEGEEILKNDILALYLGSANRDEEAFEDGESFNPYRKEKRHMAFGQGIHFCLGAPLA
RLEARIALEEFSKAVPGFEIEKPSPDDRIDSDIMYGFRKLNLKVNRS
CYP232A2 Picrophilus torridus, Archaea; Euryarchaeota
coded_by="AE017261.1:98333..99481
also YP_022863 in Entrez protein
Paul Ortiz de Montellano
Submitted to nomenclature committee May 25, 2006
Gene PTO0085
60% to 232A1
MYIPSYKEEPFEWYKSMRTQRIVREGNSVHVFKYNDVVTVLSNH
NVFSSQFRDLLGDDIKNELDSRAAPSILILDPPRHTELRGLVSSAFTPRKIESYDNYI
RELAAKMIENIIEKRRCDLVSEISYPLPIMVISNMLGVPEKDLKKFKEWSDALATSLG
RGPDLRTQREMSEYFLNMIDRDSNDDNLISRLSNVSIDDKKLTDQEITGFSILLLVAG
NETTTNLITNALIELSNHPDIYKELVDNNKIAGDIVEETLRFRSPVQSTRRYAKYDYQ
INGFNIYKNDFIFLYLSSANRDEEIFKDPDNFNPFRENKRHIAFGNGIHFCLGAPLAR
LESRIVLEEFAKRIESFSIERLNPDDRIDSDIMYGYKRAIINVKKINQ
CYP233A1 Gloeobacter violaceus
GenEMBL NC_005125 complete genome
complement(2058447..2059673)
40% to 107X1
MSALPPPRFNPFDSEFRQDPYRVYAHLRVAAPIHRSLGMWVLTR
YADVLAVLKDPHFSSSQIPLAVRQRSERPDQAQSHPLARLAAKSIVFTDEPDHTRLRH
LVVRAIKRRTPEQEQAHLTRIASALLERVGPKGRMDAVADYAERLPLQFMAESMALPP
DSWQTVRDWTHQLRYLLEPGLMGRGDFERVQAVLDEVIAFFEDMLAVRRQQPGDDLIS
ALDAAHREAQADRLSDEEIVYCCIMMFVAGHETTRSLIASGLLALLQHPEQLAYLRMH
PERMGAAVTEMLRYESPLQQTKRRATAAVAVGGRTIQPQEQVLLCLGAANRDPARFEQ
PDRFDITRTDNGHLAFGQGMHHCLGAALAQMEAQVALRVLLERFANLTLQDTPEWLEH
SFILRGLKTLPVQWDR
CYP233A2 Frankia sp. CcI3
YP_480709.1
ABD10980.1
64% to CAJ62096 same as ABD10980
76% to YP_001506247 EAN1pec
55% to CYP233A1 Gloeobacter violaceus
MSTGGMTSPTPSTATADTATADTATAEATRAPIRFNPFGAEFRRSPYPLYARLRGAQPVHRTLGMWVLTR
HADVRGVLHDRTFSAGLIPQLVSRQASRLSRDDVARIGRLATKSLVFTDNPDHARLRGLVNRVFTAQAVA
ELRPRVHEVAERLVRRAWDDGGMDVVADLAGPLPLTVMCDWMALPDSLRERVGPWTHDIRFLLEPGLMKT
EDFTRVSDVVETFAQALDDVVTERRSRPGDDLISRLLAARTAGGDRLSDEEVVFVCIMCFVAGNETTKSL
IGNGLLALLQHPDQDARLRRRPELLGGAVDEALRYDSPLQLTKRVATREVEIDGSRIRAGDQVLLCLGAA
NRDPAVFSRPDEFDITRDARGHLAFGHGMHGCLGGILAQLQAQVALDRLYRRAERLELLVTQPDWQDHSF
IVRGLKQLPVSVRGVG
CYP233A3 Frankia alni ACN14a
YP_713660.1
CAJ62096.1
63% to YP_001506247 EAN1pec
49% to CYP233A1 Gloeobacter violaceus
MPTPSTASTASAAPTAPAAARFNPFSAAFRADPYPVYRELRRTSPVLRTMGMWVLTRHADVRAVLHDRTF
SAGLIPRLVSRAAGGDALGSVAAGNSGRSGNAERMVQLAHTSLVFTDNPQHARLRALVNRVFTTAEVTRL
RPRIAAIARGLLDRALSDCGGLDAVTDLAGPLPIAVLSEWMALPDDVRGEVGRWTHDVRFLLEPGLMAPG
EVDRVGEVVATFADAMAGVIAARRARPGDDLVSRLLAARTGGGDRLTDTELGFLCIMCFVAGVETTTALI
GNGLLALVHHPDTAALLHRRPELVAAAVEEALRYDSPLQLTKRLATRDVELGGSRIRAGEQVLLCLGAAN
RDPAVFDRPDTFDITRPAGGHLAFGHGMHGCLGGMLARAQAEIVFGCLTGRAERLAPAVDRHGDAGGRDL
PRQEHSLIVRGLTSLPVALAGAW
CYP233A4 Frankia sp. EAN1pec
YP_001506247.1
ABW11341.1
51% to CYP233A1 Gloeobacter violaceus
MTPRAHEAAVDEAAAAVDGTPAGRAPGGGAAGGGRAAIRFNPFGAEFRRDPYPLYRRMREAQPVHRTMGM
WVLTRHADVQGVLRDRTFSAGLIPQLVSRRAGQLARANVDRVVRLGEKSLVFTDNPDHARLRGLVNRVFT
ATEVAALRPRVEEVAGGLVRRALAAGGMDAIADLAAPLPVTVMCDWMALPDGLRAQVGPWTHDIRFLLEP
GLMRAGDFEHVCDVVETFARALDGVVAERRQRPGGDLISRLLAARTAGGDALTPEELIFVCIMCFVAGNE
TTKSLLGNGLLALLRHPDQAARLHRAPELAGDAVTEALRYDSPLQMTKRVATRDVDVDGRRIRAGDQVLL
CLGAANRDPAVFDRPDEFDVTRAPKAHLAFGHGMHGCLGGLLAEMQAQVVFERLFGATTSIEPRTDQLEW
QDHSSIVRGLRHLPVTLHPAAPR
CYP234A1 Photorhabdus luminescens subsp. laumondii TTO1
GenEMBL NC_005126 complete genome
complement(4894114..4895217)
locus_tag = plu4183
very poor match
MMNVLINEYKKKMDSVRLGDPERKGFFYDAKQAIWHCYSYDICS
YFLNSDYVTKKKLSIPLEIFSASDQSRVARFILYLNNSLIFNDDKYNTDAVSFIRGKF
NEMNFEVIANDLLSPLKQCDLLTAKHLRGVNNLLAASLVGLKASAFFSAHALNVGMFF
DGSMSGRAHFVSIAESFIAIYQQVLRQITINGGAEDVIHIEKFVADLSVTFIAAHETT
MQLIIATFLYIKSHVITVTENNIKSIVTETYRLSSPVLAVNRVFKERLIYKNSCFNKG
DRVLFYTGLANFDATVFDHPYQFQLDREGCPLSFGVGVKKCIGMNIAIHFTCQLITKI
LSCYQLDDVEIHEVTVGSLAIGCSKFTLKISKK
CYP235A1 Streptomyces antibioticus
GenEMBL AJ002638 184..1389
35% to 131A1 no heme sign.
Gene = oleP1
MEDSELGRRLQMLRGMQWVFGANGDPYARLLCGMEDDPSPFYDA
IRTLGELHRSRTGAWVTADPGLGGRILADRKARCPEGSWPVRAKTDGLEQYVLPGHQA
FLRLEREEAERLREVAAPVLGAAAVDAWRPLIDEVCAGLAKGLPDTFDLVEEYAGLVP
VEVLARIWGVPEEDRARFGRDCRALAPALDSLLCPQQLALSKDMASALEDLRLLFDGL
DATPRLAGPADGDGTAVAMLTVLLCTEPVTTAIGNTVLGLLPGQWPVPCTGRVAAGQV
AGQALHRAVSYRIATRFAREDLELAGCEVKSGDEVVVLAGAIGRNGPSAAAPPAPPGP
AAPPAPSVFGAAAFENALAEPLVRAVTGAALQALAEGPPRLTAAGPVVRRRRSPVVGG
LHRAPVAAA
CYP236A1 Microscilla sp. PRE1 plasmid pSD15
GenEMBL NC_002806 40616..41776
32% TO 109A1 C-TERM
MKKDLIPDPFEKTREAAGYGEMNDQNDPVTMILRLKDVRKCAHN
FKTFQSGARPGRIVVPSEVSIRDTRQIPFEVDPPEHTDYRALVEPWFKRPLEAEYREK
LSQQIGYIVEERLARDAVEVVEEFSLPLQSRALTLLLNIPIEEAETWIKWGTHVFRSE
DSPVDGDKAKILYDYIDQQIDRALEKPGEDLYTVLLNSEINGKKLSREEVKGVMILTF
AGGRDTVINAVTNSVAYFAVHPESLELLRKEPEITGRAVEELIRYFAPLTHMGRVVTE
DTQVCEYAVKADSRISLVWASANRDSSVFEKPNEVVLDRKINPHVSFGFSHHNCLGAT
HARQIMHILLKTLAEKVGSIEIQEHEDNIETWGEFERKVGYDRLKVQFNPLQ
CYP237A1 Pirellula sp.
NC_005027 complete genome 6102783..6104327
34% TO 184A1 C-TERM
gene = cypX
locus_tag = RB11252
MRNGTSYLQNFFPGYRRLSRLPKQCLAINPFAGDCMPSRVRLLA
PRSDRPTQPFPHRWNYEDPVRILETYFWKADEEQGPGRHNRYLDVPGFAPVLVTRDPG
MIRAIATATGDREGQFDRDTLPSVGIARATGTDTLLYANGAEWKKQRKIAACPFGKTT
LFQPEQFCEFADTFRETVRGRIDVLRQHLTASGKKTVDIQLEPEVKVVMLEMLTNNFF
GADISYEELREKYVPALERVIDHIVKDTVKNRLGIPWRKFPSVSDRIVRAKADDATFE
ELTQRILVPRGEKKALWKQFKSDAPDAKLISNLKVFLAGALEATTSYATWAISHLARH
PDAQEKVFEEVKDIDVYTPEILAGAKYLRAVLDETLRLTPSLYFLPRRATADTWVTSA
DGRKMFIPWGTHLLLDVWHANRHEDHWGVQVSGYPANEFEPDRWRILAEWGRATKDTL
HFGFGHGPRVCPGKHLGELEVGLTVGALVKTFRFQSESPENLARAGVSTKPADGTRVC
MSLRLS
CYP238A1 Pseudomonas putida KT2440
NC_002947 2211866..2213101
26% to CYP101A1 30% to 107X1
locus_tag = PP1955
MEILDRPQAPSDFNPMSEQSFRDPASICQRAREETPVFFYAPLG
VWMVTRREDAERVLSEWETFSSLANSPNVPEEFRSRFAPSVMADSIVAIDPPRHTQAR
NVIQRGFMKPKIDPLEPIIEQRAHEIIDRFAGESGTEIMNNYCLELTTRTLMALYDLP
LEDRPMFERIRDVSIKVLASVYEPMQEPEKSRVWNEYVSGYEYFYQLVEQRRNSDARD
IISTMASQKDNQGNPALSTERIALHLVEIAFAGTDTTAQMMANAILFLDSHPEALAAA
KADKTLWSRVFEETVRRRPSAPFAGRITTTEVEIQGVKIPAGSPVWVSLAAANTDPRH
VGCPMNFDINREAPQDHLAFTKGRHTCPGAPLARLQGATGLRVLFERLPELKVVPDQP
LNFAPMALLPVRLSLQVIW
CYP239A1 Pseudomonas aeruginosa strain SG17M
GenEMBL AF440524 34312..35472
Integrated gene island PAGI-3(SG).
38% to 194A1 96% 14 diffs to CYP239A2 AJ311159
gene =ORF SG16"
MKDVNEVARNFDFHGEALDDIFDTYSTLRHGCPVGRSENYGGFW
FLTKSDDIFAAEQDPEAFSVYPSMMVPSVSEGIQLPPIDIDPPEHTAYRRILLPLFTP
QELKKLEQPIRDTARKLAEEFAKEGSGADASYHYSRPLPTIIFSRLAGYPEQDWPKFD
KWVDDIIYERVEKPEVANQASKDVFSYFENLLDNWKDDSESANLIDYLCRAKINGRPL
TRDELLRYCYLLFLAGLDTTAWSIRAGLWYLANNPADQQKLRDNPDLIPLACEEFLRT
LSPVQVMARTCLKDTVIRDQEIKAGERVMLVFGAGNRDEEVFPNPDKIDIERQENRHL
AFGGGIHRCLGSNLGRRELVVGIEEFLRAVPQFKPADPSEKWHGVGPLKLAF
CYP239A2 Pseudomonas sp. KIE171
GenEMBL AJ311159 4194..5354
isopropylamine degradation gene cluster (ipuABCDEFGH genes)
38% to 194A1 96% 14 diffs to CYP239A1 AF440524
gene = ipuD
MKDVNEVARNFDFHGEALDEIFDTYSTLRNGCPVGRSENYGGFW
FLTKSDDIFAAEQDPEAFSVYPSMMVPSVSEGIQLPPIDIDPPEHTAYRRILLPLFTP
QELKKLEQPIRDTARKLAEDFAKEGTGADASYHYSRPLPTIIFSRLAGYPEKDWPKFD
KWVDDIIYERVEKPEVANQASKDVFSYFENLLDNWKDNGESANLMDYLCRAKIDGRPL
TRDELLRYCYLLFLAGLDTTAWSIRAGLWYLANNPEDQQKLRDNPELIPLACEEFLRT
LSPVQVMARTCLKDTVIRGQDIKAGERVMLVFGAGNRDEEIFPNPDKIDIERQENRHL
AFGGGIHRCLGSNLGRRELVVGIEEFLRAVPQFKPADPSEKWHGVGPLKLAF
CYP240A1v1 Bordetella bronchiseptica
NC_002927 3943708..3944865
extremely poor match may not be a P450
locus_tag = BB3721
100% to B. parapertussis 98% to B. pertussis 7 diffs
MIADTARQHRGDIMQPADPLEAVAHPDPYPYYAALARERPFYHD
DRLGLWVAAGPQAIRAVLTCPAARVRPPGEPVPAALGAGPAAQMFGRFIRMNDGAVHE
RLKPMLTAYLTQRTAADLAEPAWPAIGNDPAQVDRYLYQAPVHAQACLMGLPDEVAAS
CAREIEAFMAACRPGADAAAVARADQAAQALQARMLAHLRAARGDAALGVLRRLALAG
GVEADALAANLAGLLLQSCEAGAGLLGNALVHAGRLSPAAAAAAPDLLHTCVEIVTHV
ARHDPPLHNTRRFLAAPATLLGQSVPAGAGILVVLAAAHALAEGAWPWTFGAERHACP
GRTPALLHAAQALAHALRHGVDAPALARRVRYRPLPNARVPRFHFPPGDTP
CYP240A1v1 Bordetella parapertussis
NC_002928 3527249..3528406
locus_tag = BPP3270
100% to B. bronchiseptica
CYP240A1v2 Bordetella pertussis
NC_002929 2545572..2546720
locus_tag = BP2405
98% to CYP240A1v1 7 aa diffs
MIADTARQHRGDSMQPADPLEAVAHPDPYPYYAALARERPFYHD
DRLGLWVAAGPQAIRAVLTCPAARVRPPGEPVPAALGAGPAAQMFGRFIRMNDGAVHE
RLKPMLTAYLTQRTAADLAEPAWPAIGNDPAQVDRYLYQAPVHAQACLMGLPDEVAAS
CAREIEAFMAACRPGADAAAVARADQAAQALQARMLAHLRAARGDAALGVLRRLALAG
GVEADALAANLAGLLLQSCEAGAGLLDNALVHAGRLSPAAAPDLLHTCVEIVTHVARH
DPPLHNTRRFLAAPATLLGQSAPAGAGILVVLAAAHALAEGAWPWTFGAERHACPGRT
PALLHAAQALAHALRHGVDAPALARCVRYRPLPNARVPRFHFPPGDTP
CYP241A1X Enterococcus faecium
NZ_AAAK01000185 complement(2963..4222)
Gene = Efae1119
36% to 152B1
renamed CYP152M1
MKEVPVVDIKITDLKKLYQKGYNMLEELRHEADAPVVKAKIFNK
EAITIYGSSAAKVFYDPRNFKRKGAMPKLVLKTLFGQGGVQTLDGAAHHHRKNIFMDL
MTPERMEDYHRILDKNLTQALEAQHGQFELFDLSKMVFFTSICEWAGINLSAISKDEV
EKLAEYQISMISGTFTSPIDHIKGVENRKKSEKWAQGLIEEARQNPVAGKENVALYAF
ANATDLDGQLLPLEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFSTL
QDPFIQEMRRYYPFFPMLPAISLKEVEVDGYRIPEGSWVILDLYGTDHDERTVEAPDS
FMIKRYVGKAKDISYKEEYEMIAQGGGNFRQMHRCAGEWITLHSLRVFSDQLVNKFEF
SVPEQDWTIPFNQFPTYPNSRALLYKN
CYP242A1 Kitasatospora griseola
GenEMBL AB048795 2479..3729
36% to 107P1
MADLETKFPRYELISSGKYVDRIPELHELREKSPIAWVPVMDAA
FLTRHADIVRVLKDHRMAPANLTQGIRLLSPEQQEELEPLSSAVKKWMGHTVPADHQR
FIGLLKRYFTPAMIDRMRPRVRQLSHELLDAVEPAGRMDIVSDIAYPLPACVIAEMLG
VPMDNRAQLLAWSADIGAIAEIVSYDRLMECQRSLLAMQDFVLEVVKERRAEPKDDLI
SMFVAAEREGLVSEAEILSNCVMLLFSGHETTGGLITSGLVQLFDHPDQLELLKSDPD
LMPGAVEEMLRLAGPASVISRVSTEPVEVAGSSIRSGAAVPPGADGGKRDPRVFEDPD
RLDATRRPNDHLAFATGMFYCLGAALARMEADEFFRILLDRFPDVNPGYETPDWQPVL
LISRRLKTLPVNLRGVGGSGAGDE
CYP243A1 Mycobacterium avium
AF232829 complement(389..1609)
38% to 222A1
MTPTRSTSTNWPSTPNCGNDVRSRGTRTTAGSGSSAATTPSAKP
PQRRHFRPQSTSRTPQTAWTTRARWASRDPEGQPALGLGEVDGPYHQALRHALAPFFS
PGAVEKLNPFMEQSAHWFLDQQITTGQMDLVLDYASPVPAILTMKLMGLPYDNWRLYA
NLFHSVMAVSQDSDEYAAAIAKVPAMMHEVLDYAATRRAKPEEDLTSFLIRFEFDGHR
LTDEQLLNILWNLIGGGVDTTTSQTALTVLHLGTHPDLRQQLIDHPELYRTATDEFLR
YFSVNQTLSRTVTHDVVLAGQRLRKNDRVVISWLSANHDENEFDRPDEIILDRAPNRH
VAFGLGPHRCIGSHLARLMSEVMVRAVLXRIPDYQVDVENVHQYLGNPSMTGLGQLPV
TFAPGKSRKTLRPW
CYP244A1 Streptomyces sp. TP-A0274
GenEMBL AB088119 complement(5410..6594)
staurosporine biosynthetic gene cluster
31% to 107B1
gene = staN
MTDMPVDPGPFDCMPELLAAARVAPVVRIPYLEEHAWVVCDPEL
VRTALTHPKMAKDITLVPQFMRKPGLMVGSQPPPEYARAMIMSDGEDHARIRRVHQPV
LSPRNTQRWGERVGVKVGGFLDELEQSRASDSAEVDVVTDYTHRVPLAFISEMLGLPL
EAERRLRSITDVMLYSSDYPARQEAVGALFGAVESWVQNPAPLRDGVITGFLAAADGP
DKVTEGEVIVWTVGMIITGYETTGSLISASLYEALRRPPEERPGTDEEIKSWIEEALR
VHPPFPHPTWRFPTEDIELGGYLIPKGAPVQVSIAAANRQPGEGADSFEAARGGHGHL
SFGLGMHYCIGASLVRLEAQIAVREFLRRFPKARLSDGSAVQWESEWMIRRLSALPAVLN
CYP245A1 Streptomyces sp. TP-A0274
AB088119 13260..14513
staurosporine biosynthetic gene cluster
38% to 107P2 53% TO Lechevalieria (10860..12053)
gene = staP
MASATLPRFDLMGWDKKDIADPYPVYRRYREAAPVHRTASGPGK
PDTYYVFTYDDVVRVLSNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLD
PPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILV
ISALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRG
GDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDV
LDELRTTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANR
DPARFPDPDVLDVHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALLDGIPALGRGA
HEVEYADDMVFHGPTRLLLDLPDAA
CYP245A2 Lechevalieria aerocolonigenes
GenEMBL AF534707 complement(10860..12053)
36% to 107P1
gene = rbmE
MKPFDLKAFTGADLADPYPVYREYLTGDPVHHNGEAWYVFGYDG
VAHVLTSRDYGRRGPGGRATPIPPSHDTLSRIVENWLVFLDPPRHTALRSLLAKEFSP
AVVTGLRERVRKIAGELLAGLGDAGEIDLVEDFAAPLPILVISELLGVPARLRSWFRR
CAVDLQEASTARATRNPGALARADGAASELVEFFGGELGTRKPDDEDLVALLVNAQRR
GEALTDEEIVSTCVHLLTAGHETTTNLISKSVLALLANPAAAAEPLAGLDVTPQVVEE
LNRFDTPVQMVTRWAHQDTALGGKPIRRGDKVVLVLGSANRDPAAFAEPDRLDLRRDS
RRHCGFGLGIHYCLGAALARTEAEIGLSVLFTNFPGLRLGGEPVRYADDLVFHGPARL
PMLTR
CYP245A2 Lechevalieria aerocolonigenes
GenEMBL AB090952 15478..16671
rebeccamycin biosynthetic gene cluster
gene = rebD
100% to AF534707 rbmE
100% to Saccharothrix aerocolonigenes rebP
CYP245A2 Saccharothrix aerocolonigenes
GenEMBL AJ414559 15358..16551
gene cluster for rebeccamycin biosynthesis.
gene = rebP
36% to 107P1, 100% to AB090952, AF534707
CYP246A1 Streptomyces acidiscabies
GenEMBL AF393159 537..1724
40% to 105M1
gene = txtC
MESPATQVDPANSPLEPYHIYPEAKSCPVAKVGLWNGTPAHVFS
GYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRGTIAREF
LPKHIELLRPAIREIVQGVLDGLAETAPPQDMLEAFAVPVASATVFRLLGIPAEDRAL
LTRCVKGVVSAVGSEDEGAEVFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQL
TFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEHPERIPLLVEELLRY
HTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDRPSVPH
VGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMTW
CYP246A1 Streptomyces scabies
SCAB31761
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
100% to 246A1 Streptomyces acidiscabies GenEMBL AF393159
MOST LIKE CYP105 FAMILY 40% TO 105M1, 38% TO 105B1, 38% TO 105B2
CYP247A1 Actinomadura verrucosospora
GenEMBL AF411574 1..>954 runs off end
40% to 162A1
MRARAPLHHQVLPDGREFWSVTRYDDVCRVLGEHQRFTSERGTV
VTHLGVDDVAAGTLLTSTDPPRHTLVRRAIGARLTARAVAPWRERIPERDWDELVQLT
AMVTAPSDPHFRHGSEAATLAIAHHELVTYVKEWAARRRSAGGDDGSLLDHLMTVRVA
GAPLTDEEIALDGYSILLGANVTTPHTVSGTVLALIERPEQFGKVQADPSLVPNLVEE
GLRWTSAACNFMRYAVDDVRIAGGTIPARGAVVAWIGSANRDESQFADPHTFDVTRNA
SRQVAFGYGPHYCVGAPLARLTLRVFFKELLRRFGSLSSGGS
CYP247A2 Frankia alni ACN14a
YP_712777.1
CAJ61205.1
75% to CYP247A1 Actinomadura verrucosospora
MRLSPGAASDVDLDRLDLFDLDLYSSGDPHAIWEVMRAQAPLHHQVLADGRAFWSVTRYDDVRAVLGDHR
RFTSERGTVVTHLGEDDLTAGKLMTSTDPPRHTQVRRAIGTRLTARAVASRQNQIRQAIVRFLEPLLDGG
TDDLAERALRLPMVVAGPLLGIPERDWDELVQLTAMVTAPSDPHFQCGGRAATLAIAHHEIVTYVTDWVR
RRRSSGERDGSLLDHLMSVRAGDAPLTDEEIAYDGYSLLLGANVTTPHTISGTVLALVELPEQFDKAQAD
PTLVPSLVEEGLRWTSAACNFMRYAACDTEIGGGTVRRGDAVVAWIASANRDESRFADPHEFDLTRDANR
HVAFGVGPHYCIGAPLARLTAQIFFDELLDRCASIELGGAPEHLRSYFIAGMTHLPVVARKRRSS
CYP248A1 Micromonospora echinospora
GenEMBL AF497482 72606..73799
gene = calO2
calicheamicin biosynthetic locus
34% to 107H1
MTAFDPTDADVRRDPYPSYHWLLRHDPVHRGAHRVWYVSRFADV
RAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSA
LRRLEPVIAGTVDDLLRPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWS
RDVGRTLDRGASAEDMRRGHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLM
SRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRPDLLAQAVEECLRY
DPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIERDPVPSM
SFGAGMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQPRTMFRGLASLPIA
FTPGG
CYP249A1 Rhodococcus ruber
GenEMBL AF333761 12042..13244
Chauvaux,S., Chevalier,F., Le Dantec,C., Fayolle,F., Miras,I.,
Kunst,F. and Beguin,P.
Cloning of a genetically unstable cytochrome P-450 gene cluster
involved in degradation of the pollutant ethyl tert-butyl ether by
Rhodococcus ruber
J. Bacteriol. 183 (22), 6551-6557 (2001)
gene = ethB
37% TO CYP217A1
MTLSLATAQERYATDADVFAHDTLVDPYDTYRSLRDIGRVSYMT
RYDTWALTRYDEVRHALGDWQTFSSAQGIGMSTALNEAWKDFAPCKDGADHLPMRKLM
MQDLGPKAAAAYKEKIQQAAVTLVEELLDRREFDAVLDFAQMMPMRVFMEVLGVEPDI
EQRRTMLHWGTDTYNCAAPDGLYDDTLPSMDKLYSWALENITPETAREGSVAASTWES
VERGDITDVQAVATLAAYVTAGLDTTAGTLGNTIAQFAANPDQWAIVRDDPKTIPGAI
LEGIRFDSVAQWFTRVTTRDVEYDDIVIPAGSRTYHSYAAANRDERHYRDPDSFDVLR
NPTDHVGFGYGPHMCVGKSVSNTEMIALWTELGRRVDRIEQIGPKKQHINNLIRSLDS
LPVRIYPK
CYP250A1 Arthrobacter aurescens
GenEMBL AF146701
32% TO 219A1 N-TERM ONLY
MKEPLDFADPTLYQNPVPAFNKMREEHPVFWSDSAGSWVVSRHA
DVVRVLNNLEDAQASLFKINDYAEQCPFGKGTAISRGIENALVTTDLPDHPRLRRHTA
PLLTRRSVERDYAETVEQTVIALLEGIEEDTRFDVLDSISVPLPLAVVTKLIGFDAED
CYP251A1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
38% to 183A1 and 171A2
clone name SP0759
CYP251B1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2317 42% to CYP251C1
CYP251C1 Amycolatopsis mediterranei U32
GenPept ADJ49978.1
CYP251D1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2320 42% to CYP251A1
CYP252A1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
39% to 197A1
clone name SP0812
CYP253A1 Streptomyces peucetis
No accession number
Niranjan Parajuli
Submitted to nomenclature committee Nov. 2, 2003
36% to 197B1
clone name SP0913
CYP253A2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_4844
85% to CYP253A1 Streptomyces peucetius
CYP253B1 Streptomyces peucetis
No accession number
Pramod Shrestha
Submitted to nomenclature committee May 16, 2008
Clone name SP_4173
44% to CYP253A1 Streptomyces peucetis
CYP253B2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_4843
83% to CYP253B1 Streptomyces peucetius SP_4173
CYP253C1 Streptomyces peucetis
No accession number
Pramod Shrestha
Submitted to nomenclature committee May 16, 2008
Clone name SP_9081
45% to CYP253A1 Streptomyces peucetis
42% to CYP253B1
CYP254A1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha02824
Submitted to nomenclature committee 12/13/04
36% to 239A2
CYP254A2 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha02853
Submitted to nomenclature committee 12/13/04
68% to 254A1, 67% to 254A3
CYP254A3 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha02973
Submitted to nomenclature committee 12/13/04
70% to 254A1, 37% to 239A2
CYP255A1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha04605
Submitted to nomenclature committee 12/13/04
54% to 255A2
CYP255A2 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha05312
Submitted to nomenclature committee 12/13/04
54% to 255A1
CYP255A3 Rhodococcus sp. R04
No accession number
Riu Xue
Submitted to nomenclature committee March 17, 2011
58% to CYP255A1 Rhodococcus sp. RHA1
CYP255A4 Rhodococcus sp. R04
AFAQ01001933.1 15866-17097 (+) strand
Riu Xue
Submitted to nomenclature committee Feb. 28, 2012
62% to CYP255A3 Rhodococcus sp. R04
CYP255A4 Rhodococcus pyridinivorans AK37
AHBW01000047.1 54163-52952 (+)
98% to CYP255A4 Rhodococcus sp. R04
CYP255A frag Rhodococcus rhodochrous
Swiss P31718 (20 amino acids)
Eltis L.D., Karlson U., Timmis K.N.
Eur. J. Biochem. 213, 211-216 (1993)
85% to CYP255A2 rha05312 (3 aa diffs no start Met)
TSTLSWLDEITMEELERNPY
CYP256A1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha09714
Submitted to nomenclature committee 12/13/04
CYP257A1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha10525
Submitted to nomenclature committee 12/13/04
CYP258A1 Rhodococcus sp. RHA1
No accession number
Marianna A. Patrauchan
Rha10666
Submitted to nomenclature committee 12/13/04
CYP259A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_4259
36% to 117A3
CYP260A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_1461
48% to 260B1, 35% to some CYP107 members
CYP260B1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_4416
48% to 260A1
CYP261A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_182
No strong matches
CYP261B1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rita Bernhardt
Submitted to nomenclature committee Oct 18, 2007
Sce5725
49% to CYP261A1
CYP261C1 Photobacterium profundum strain SS9
YP_133374.1
see link
Dmitri R. Davydov
P450-SS9
41% to CYP261A1
CYP261C2 Photobacterium profundum strain 3TCK
ZP_01217946.1
Dmitri R. Davydov
P450-3TCK
97% to CYP261C1
CYP261D1 Moritella sp. PE36
ZP_10899073.1
Dmitri R. Davydov
P450-PE36
47% to CYP261C1
CYP262A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_2000
39% to 205A1, 252A1, 38% to 253A1
CYP262B1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rita Bernhardt
Submitted to nomenclature committee Oct 18, 2007
Sce1860
41% to CYP262A1
CYP263A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_4484
No strong matches
CYP264A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_5791
42% to 264B1, 37% match to some CYP107s
CYP264B1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_7808
42% to 264A1
CYP265A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_7503
37% to 151A1
CYP266A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_5168
40% to 107AA1, lower to other CYP107s
CYP266B1P Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rita Bernhardt
Submitted to nomenclature committee Oct 18, 2007
Sce6630
45% to CYP266A1 C-term only, probable pseudogene
CYP267A1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rolf Muller
Submitted to nomenclature committee 8/5/05
Clone name sce_040811_619
41% to 107P1, 40% to 195A2, borderline CYP107-like
but also similar to CYP195
CYP267B1 Sorangium cellulosum So Ce56 (myxobacterium)
no accession number
Rita Bernhardt
Submitted to nomenclature committee Oct 18, 2007
Sce7167
43% to CYP267A1
CYP268A1 Mycobacterium avium subsp. Paratuberculosis
GenEMBL AE017235.1
CDS complement(103932..105242)
MTGVIAERIGIMAVLTGESGTDRSGRPYDEIDLSSRAFWSGTAA
ERERSFAVLRAERPVSWHPPVEDSLLPDPTDPGFWAVTRRADIVTVSRNNDVFLSGHG
VMFESIPAELLEASQSFLAMDPPRHTKLRKLAHAALSPRQVRRIEDSIKANAKAIVEE
LRSAGSGCDFVDHCAKELPIRTLSDMMGIPESERERMAHATDALVSWADPEFLNGRPA
LEVLLENQMYLHQVVGDLATQRRERPGDDLISSLVTAEVDGDRLEDAEVAAFFVLLSV
AGNDTTRQTISHTLRALTVFPDEKFWLLEDFGHRIGTAVEEFIRWASPVMTFRRTAAA
DVELGGQTILAGEKVVMFYPSGNWDTEAFDHPERLNLGRDPNPHVGFGGGGLHFCLGA
HVARAQLRAIFSELFRQLPGIQAGEPTYLAGNFVHAIRAMPCTF
CYP268A2 Mycobacterium marinum
No accession number
Tim Stinear
MM3761
78% to CYP268A1 Mycobacterium avium subsp. Paratuberculosis
41% to 124A1 40% to 125A1
CYP268A2P Mycobacterium ulcerans
No accession number
Tim Stinear
95% to 268A2 M. marinum
CYP268A3 Mycobacterium smegmatis
MSMEG4612 TIGR
77% to 268A2 Mycobacterium marinum
76% to 268A1
50% to CYP268B2, 52% to MSMEG3700
51% to CYP268C1 Mycobacterium vanbaalenii
48% to CYP268B1 Mycobacterium vanbaalenii
45% to CYP142B1 Mycobacterium vanbaalenii
formerly 124B1 but new sequences caused a split of 124B from 124A
MTVLPITRPYDAVDLSSRAFWATTAADREVAFAQLRAERPVSWHPPVEDA
LMHDPDDKGFWAVTRHADIVAISRDSETFLSGQGVLFENVPQELLEASQS
FLAMDAPRHTLIRKLVHSAFTPRQVARIEDSIKANAAAIVAELKAAGSGV
DFVDHCAKELPIRTLSDMVGIPEGEREKVAHAADALVSWADPIYLAGRHP
LEVLLENQMYLHQVANTLAAERRENPGNDLISALVHAEVDGDRLTDAEVA
AFFVLLAVAGNDTTRQTTSHALKALTDFEDQRAWLMEDFDDRIGVAVEEM
VRWASPVMTFRRTAAVDVELGGRQIAAGEKVVMFYASGNWDTTVFDRPDV
LDLGRKPNPHLGFGGGGRHFCLGAHVARTQLRAIFGELLHQLPDIRAGEP
EYLQGNFVHAIRAMPCTFS
CYP268A4 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_1278
53% to CYP268A2 Mycobacterium marinum MM3761
55% without the small insertion
CYP268B1 Mycobacterium vanbaalenii PYR-1
ZP_01206299.1, EAS24061.1
49% to 268A2
MSGSPDRRRSADHDHPAAVAACRQLYKLTVKCHANSVTAPSLHEREHSAIDITSHDFWSRPFAQRDESFA RLRAGDGLSWHAPFPSLFPMEEPGYWAVTRRADIAYVSQHPELFTSERGVALDPMPAEVQRFASFFLTMD PPQHTTYRRLISSAFTPRNVRQIEEQIQRNAVAIVDDLVGAGDIDFVADCSARLPMLTIMEMLGVPGADQ PAVALAAEKLFSMSDDEYSSLEERAANTLNEIMLLSSTGAELAKFRRAHPGDDLMTGIVNAEVDGQRLTD EEIGAFLILLASAGNDTTKQTTTHAMMALVENPQQRAWLMADFDGRIGAAVEEFVRWSSPVLQFARFATR DTEINGQPVAEGDKVGLFYCSANRDEAVFDNPAGFDLSRSPNPHLGFGGGGPHFCLGNQLAKAELRNLFR
ELLTRLKTVEFGEPDLLHSSFVHGVKRLPAHVR
CYP268B2 Mycobacterium smegmatis
50% to CYP268A3, 40% to CYP124A1
78% to CYP268B1
formerly 124C1 but new sequences caused a split of 124C from 124A
MTVASSAQAREYSPFDITSHEFWSRPFAVRDETFAQLRAAEGLSWHQPLS
TLFDVEEPGFWALTRRADIQFVSQHPELFTSAQGVALDPMPADVQKFATF
FLMMDPPEHTVYRRLISSAFTPRNVRRIEEQIHANAVDVVDQLIGVGNVD
FVEACSAQLPMRTISDMLGVPKADQPALAKAAEKLFSMSDDEYSSLEERA
VATINEIMLISNTGVELAKFRRANPGDDLMTSIVNAEVDGHRLTDEEIGA
FLILLASAGNDTTKQTTTHAMMALAAHPDQRDWLMADFDGRIGPAVEEFV
RWATPVIQFARFATEDVEVAGQTIRAGEKVGLFYCSANRDEAVFTDPQRF
DLSRSPNPHLGFGGGGPHFCLGNQLAKTELRNLFRELLTRLKTIEFGEPE
LLHSSFVHGIKRVPAYIR
CYP268C1 Mycobacterium vanbaalenii PYR-1
ZP_01209026.1, EAS21466.1
51% to 268A1, 44% to 268B1, 42% to 268B2
MQIDEYLAATSDNKPDHCDIDISRKAFWARPADEKMEIFAALRAEHPVSWQRPIEGAVVPDPDDPGFWAV VRHADIRQVSHDNRTFISGQGVMFDRLPPLFLEMALSFLAMDPPRHDKLRRLVNKAFTPRQITRIEDKID LVAKEVVDGFIADPTGEIEFMDRCASRLPLRMFCEMFGVPDHLEERTVEHVIGSVSWSDEEILAGRSAAD MQLESIGGLHQVAQEIIEMRRQQPGDDIISSLVHAEIDGQMLTDFEISSFFCLLSGAATDTTKTTLGHAV RALSLFPEQHAWLLEDFDNRIGTAVEEFIRWATPLLTFTRTAAVETELGGRRIMPGDRVVMIYQAGNFDE DVFDRPRELDLARSPNPHVSFGGGGVHYCLGANLARSMLRAELRELLLRITEFETDAPDMLATNFIHGLK RLPFRFTPQ
CYP269A1 Mycobacterium marinum
No accession number
Tim Stinear
MM3969
40% to 107E1, 34% to 107G1
CYP269A1P Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 269A1 M. marinum in conserved region = ortholog
CYP270A1X Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017229.1
CDS complement(151750..152955)
name changed to 190A2
MTKPKLVFDPYSEDYFNNPYEIYRRMREEAPLYYDEKEDFYALT
RHVDVAAAFKDYETYSSARGCDLAMVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTP
RAIQSQRETIIEVVDKYLSAADPDNFDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
IDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQDPQDDMISRLIAAEIPGENG
QMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVIFARHPDQWQKLQEDRDKIPGAVE
ELLRYEGPVQYNVRYTLKEAHVSGGVIPAGKPVFLCGAAANRDPEAFTDADTFDIERD
QTEAQHLGLGYGIHSCLGAALARLESRIALERLLDFMPRYDVDWAGCRRVTMQNVAGW
KNVPVKVLR
CYP270A2X Mycobacterium marinum
No accession number
Tim Stinear
MM4733
69% to 190A2 Mycobacterium avium subsp. paratuberculosis
38% to CYP123A1
name changed to 190A3
CYP271A1 Mycobacterium marinum
No accession number
Tim Stinear
MM0274
40% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
38% to 127A4
CYP272A1 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017234.1
CDS 77322-78491
MTEAGGFVDQTVTGVAEPQPMYKALRESNPVFRSTQAVVLSRLA
DIEMALKHTELFSSNMDAVDLGNVRPLIPLQIDPPDHAKYRRILDPLFTPREMARREP
LVTELVNEMIDRFAPRGECDFHAEFAVPLPCTVFLQLLGLPLEDLDRFLLWKDGVIRP
AGDSGFDRRHESSAGVAQQIYEYFDKAIDEHIAVPRDDVLSAMIAADVGGQPLSREEL
LDICFLFLIAGLDTVTDSLDCFFVYLARHPQHRRQLVERPDVLPGAVEELLRWETPVP
GVARVATQDVEVGGCPISKGERVSPLLGAANTDPAEFPDPEIVDFTRSPNRHRAFGGG
PHRCLGSHLARMELRVALREFHRRIPDYEIRPGTQLTYTAALRSVESLPLVFPVR
CYP272B1 Frankia alni ACN14a
YP_714029.1
CAJ62469.1
46% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
MPDDTAGAAAPADGGHGLRAATLDWLEFERQRAEDPRAYFSRLRAKCPVDYDEGHEGWIQILRRAEIDEV
LRNPEVFSNLIPELMSSPLPAIPMGVDPPDHAKYRRILDPLFSPRRMAALEAEVVANTVATIESFLDRGS
CDFATDLAVPLPCSVFLTLFGLPQSELPGLLHMKDALIRPESLTDDPDEKLRIQTEAGTQVFTLFGTVLA
QRRAEPRDDLITELLKAEIEGRPLTEPELLGICFMLMMAGLDTVTISLTCILAYLLEHPEARQRIVADPE
TIPAIVEELLRWETPVMAVPRIVTRDTEVAGCPVRKGEMVHVMLASGNLDPDADPRAGVVDLDRADKRHL
AFGGGPHRCLGSHLARMELRTVLREWHRLIPEYSLAPGASITWNGSTLRGLDSLALTWPTDAGQA
CYP272C1P Frankia sp. EAN1pec
YP_001511056.1
ABW16150.1
54% to CYP272A1 Mycobacterium avium subsp. Paratuberculosis C-term
59% to CYP272A1 over 171 aa
52% to CYP1027B1 over 159 aa
MAQTGTERPLIPLQIDPPKHREYRRILDPLFSPQRMKEMEGPITELARGLVDWESPVMMVARFATQDTEI
AGCPVRKGQVVTDLLGAANTDEREIPEPEAVRFNRDANRHIAFGRGPHRCLGSHLARLELRIALREWHAR
IPDYRVPDGFQPAFTTTIRSLVALPLQLDPSA
CYP273A1X Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017235.1
CDS 255472..256674
Name changed to CYP187A2
MMTNVPTAAGDETVSLRDPYPFFARKRREAGVFAGTVMDYSKTP
ESLMPKQEYSAVSFDAVNTVFRDGRVFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNL
VSAAFKSKALARWEPTIVRPICNALIDDFIDAGTADLVRQFTFEFPTRVIARLLGLPD
EDLPMFHTRAVQLISYHVDYERAFEASAALKDYFLEQIEQRKSKPTEDIIGDLVTAEI
DGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPDQFAALQADRELLAPAIE
EGLRFETPLTTVQRFTTEDTELQGVRIPARSVIGVCIGSANRDERRWERSEEFDIFRK
HVPHISFAAGEHTCLGLHLARLETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTA
LPVTFDAK
CYP273A2X Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017235.1
CDS 236687-237919
Name changed to CYP187A3
MPLSTGPTGQPVVPTLDFTGETSPYPFFEHMRRTDPVWHGSLAD
ASQLPEELRPEDEWVLFDYESVSQAFRDDRIFSSHKYDETIGLVMGHTILAMGGREHH
DHRNLVAKAFRATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTL
LGLPAEDLDLFRRLSLDLISIPTDIEAGLNAATELYDYFLKQVEQRRRKPTDDIIGDL
VAAEIDGEKLTDEAIIAFLRLLLPGGLETTYRSSGNLLYLLLTHPEQLAMVYRDRSLI
PMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAF
DIRRPRQAHIAFAGGIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIV
GLTFRSPNKLPVTFAPAA
CYP273A3X Mycobacterium marinum
No accession number
Tim Stinear
MM3996
85% to CYP273A1 Mycobacterium avium subsp. Paratuberculosis
57% to CYP273A2 Mycobacterium avium subsp. Paratuberculosis
38% to 159A1, 38% to 159A2, 57% to 273A4
CYP273A3X Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 273A3 M. marinum = ortholog
CYP273A4X Mycobacterium marinum
No accession number
Tim Stinear
MM4008
82% to CYP273A1 Mycobacterium avium subsp. Paratuberculosis
56% to CYP273A2 Mycobacterium avium subsp. Paratuberculosis
36% to 159A2, 57% to 273A3
CYP273A4X Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 273A4 M. marinum = ortholog
CYP274A1 Mycobacterium marinum
No accession number
Tim Stinear
MM0283
37% to 183A1
CYP274A1 Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 274A1 M. marinum in conserved region = ortholog
CYP275A1X Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017234.1
CDS complement(151992..153206)
MVMTGTSAIELYYDPFDSGIDDNPYPVWQRMREEAPLYYNEKYN
FYALSRYEDVARELPNWQTYRSGRGTTADILFSNVEVPPGILLFEDPPLHDLHRRLLS
RVFTPRRMLAVEDLVRGFCVRELDPLVGAGGFDFIRDLGAMMPMRTIGYLLGIPEEDQ
EKIRDRSVANIELSRDSDPAAVDANVFANSIALFADYIEWRADHPSDDLMTELLRAEI
DEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQLLSDHPDQRRELAADPSLI
PGAVEETLRFEPPSPVQARYVARDAEHYGRVVPEGSFMLLLNGSANRDPRRFTDPDRY
DIHRQGGGHLSFGQGLHFCLGSALARMEARVAFEEVLKRWPDWEVDYANAERARTASV
RGWARLPVVTGG
CYP275B1X Mycobacterium marinum
No accession number
Tim Stinear
MM0928
57% to CYP275B2
52% to CYP275A1 Mycobacterium avium subsp. Paratuberculosis
37% to 123A1
name changed to 189A6
CYP275B1PX Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 275B1 M. marinum in conserved region = ortholog
name changed to 189A6P
CYP275B2X Mycobacterium marinum
No accession number
Tim Stinear
MM4753
57% to CYP275B1
54% to CYP275A1 Mycobacterium avium subsp. Paratuberculosis
37% to 123A1
name changed to 189A7
CYP275B2X Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 275B2 M. marinum = ortholog
name changed to 189A7
CYP276A1 Mycobacterium marinum
No accession number
Tim Stinear
MM1564
36% to 107AA1
CYP277A1X Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017231.1
CDS 236434..237804
Name changed to CYP185A3
MSVAEPKRDIAGLPLAPKNPLSYRERLRAIKEFHTGTNKLRDAG
GPVTRVTLGPRWLISPIVLATSPQGIRDIVSVRDGSIDKTSTVATELRRLLGPNLFVL
PHTEWLPRRRTLQPVFTRQRVREFGGHMAEAAESVCAGWPEDTEIDLDAQCRTLTLRA
LGRSVLGLDLDERSDAIAEPLRVATSYAVRRALRPLRAPEWLPTPSRRRARAAAGAIR
ALADEILQACRADPGREAPLVHALIAATDPETGQALSDKEIRDEMIIFLFAGHDTTAT
TLTYALWALGRHPEYQARVAAEVAELPDRHLTPDDVARLGFTVRVLQEALRLCPPGPT
GTRMATRDVEVAGYRVEAGTMLAFGRMAVQTDPSLWDAPLRFDPDRFDPRRAGDRDRW
QYLPFGGGPRSCIGDHFAMLEATLALATIVRRVEIESLSDDFPLAVPFTMVAAAPIRA
MVRRRR
CYP277A2X Mycobacterium marinum
No accession number
Tim Stinear
MM0852
58% to CYP277A1 Mycobacterium avium subsp. Paratuberculosis
35% to 184A1
Name changed to CYP185A4
CYP277A2X Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 277A1 M. marinum = ortholog
Name changed to CYP185A4
CYP278A1 Mycobacterium marinum
No accession number
Tim Stinear
MM2877
35% to 107L1
CYP278A1P Mycobacterium ulcerans
No accession number
Tim Stinear
99% to 278A1 M. marinum in conserved region = ortholog
CYP278A2 Mycobacterium vanbaalenii PYR-1
ZP_01209042.1, EAS21482.1
37% to 107U2, 34% to 109B1
83% to 278A1
MTMSSTTASALELLTTASGIADPYPLYNQLRRLSPVAGYRDWPPGTIPGADEPVTAWALFRYDQVFEAAR DSATFSSRDPLQEASSAPSLMLVNTDPPKHEIERKLVSQAFSPRRVKRLEGWLGELVPRLLEDLGSGEVD VMEFAAEVPTRAMVRLLGLPDGDHVRFKRWANAFMLSSSLTPDERIASNDEMVAAFAGRLTEHTARLAEQ APTDDVEDAEDLISALLRAEVGGQRLTPEEIVRFCVTLVVAGSETTTFLIGNLLHAMARDPETTARMRAD RALLNVFVEETMRLDGPPQRLFRIATRDVEVGGKLIRKGEWVALFFGSANRDPDVFADPNVLDLDRPNIR QQLSMGHGLHFCLGASLARLEVMAVLNAVLDRYRTIALTDDPGTKQTASLLTHAYVRLPLHLS
CYP278A3 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
54% to CYP278A1 Mycobacterium marinum MM2877
49% to seawater bacterial sequence CYP278B1 JCVI_PEP_1096680833653
68% to CP000774.1 CYP278A4 Parvibaculum lavamentivorans DS-1
REGION: 3745637..3746905 ABS65098.1
Ectocarpus sctg_1 302460-301204
CYP278A4 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS65098.1 (protein)
CDS complement(3745637..3746905) locus_tag="Plav_3499"
35% to CYP107L1 AF087022 Streptomyces venezuelae
MQEIRKSDRADDLAALVAALPAGDTIASPYALYDRLRPYGPVYG
YRDYPPGTVPDADEAVTAWVLLNYDHVSAAARDHRIFSSRDPLQEQSSAPTLMLVNHD
NPEHDRLRSIVNLAFSRPRIEALDPWVREIVGGMVAGLGDGDTEVMEALAARIPARIM
VGLLGLPEEVVDRFRHWATAFMLSADLDPAEREASNAELVRYFTETVDSLYGALEAGD
PVPDGLIAALLKAEVDGEQLTLDEVIRFCITLVVAGSETTTFLLGNLLHNLAVMPDIR
AQLAANRALIGPFIDESLRHSGPPQRLFRIATQDVEVGGARISKGDWVALFFAAANHD
PAMFPDPEKFDISRPNLNKQLTFGVGIHHCLGSALARMEGRALIEAILDRMDDVSLGA
LPPVPQRASLLNHGFDSLTLRFTAREDETQ
CYP278B1 seawater sequencing J. Craig Venter Institute
JCVI_PEP_1096680833653
VAVAEMAIQAARLNSPEVIANPYPYYDQLRAASPVHGYVDLPPGTVPGQDEPKISWAVLRHADVVEA
ARDAQTFSSADPLQAESTAPTLMLVNDDPPRHSKLRAIAHKAFTPRRILEKGPWVAQVAAEILAPCG
GRCFDFMTDVAPVLPTRVMAKVIGVDDAQAPRFRNWATAFMLSADLTPAAREASNREVAAFFVDHVN
RRYALIERGGDPPDDLVTALILEDSDGQRLTRDEVTRFCITLLVAGAET
CYP279A1 Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017241.1
CDS complement(293697..294926)
MTVGAAPPSVFDSDLPTLHYHSDETPAQVYPRLREAQRRAAVAI
GPHGPEVLSYHLVRSVLRDPRFQIPPGINLLAQGIDSGPLWDKVANSLLCLEGDAHHR
LRSLCSKAFTPRTVARLHDTMAAVMNELVDRVAAAGRCDVVTDIARPYPVPIICALLG
APREDWRRFSSWADDVFKAFSFTVDLREVEPVVMRAWRELDDYVDEMVARRRHNLTDD
LLSDLIRVGDEGDRLDAAELRMLAGGLLLAGTDTTRNQVAASVQVLCEHPDQWELLRQ
RPELAMRAVEETMRHSPIACGTLRLVVEDAELDGHLFPAGTAVLVNTFAANRDPVVYN
DPDRVDITREAAPPILTFGGGVHYCLGANLARREIAEALNVLANRLRNPRLAGPAPWK
PMVSLSGPTSLPIEFDR
CYP279A2 Mycobacterium marinum
No accession number
Tim Stinear
Clone name MM0122
35% to CYP107AE1, 35% to CYP107L6 new family
59% to AE017241.1 CYP279A1 Mycobacterium avium subsp. Paratuberculosis
CYP279A3 Mycobacterium vanbaalenii PYR-1
ZP_01203523.1, EAS24515.1
70% to 279A1 Mycobacterium avium subsp. Paratuberculosis
55% to 279A5 M. smegmatis
65% to 297A4 M. vanbaalenii ZP_01203646
60% to 279A2 M. marinum MM0122
MSGDYVRDSARDHAFPCPYPPHGHTLFSIRKSNRPGSEATMVVSPTVANVFDAGLPTLTYDVFSTPAQVW PDLHDAQRTAPIAIGPMGPEVLSYEMARAVLRDTRFTIPPGINLAAQGITSGPLFDKVMSTLLCLEGSEH QRLRKLVSKAFTPRATERLHDTIVAVVDELVDNIAGARRCDVVADIARPYPIPIICALLGAPREDWRLFS DWTEDVFRAFSFSTDVATVQDDVMRAWNELDDYVDRMVAHRRRHLTDDLLSDLIRAEDDGDRLSTSELQM LAASLLMAGTDTTRNQLAASVQALSERPDQWALLADRPELAMRAVEETMRHSPVVCGAPRIVLDDVEFDG YLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGVHYCLGANLARRELAEALRILAGRL
SNPRRSGSAPWKPMLGMTGPTVLELEFDA
CYP279A4 Mycobacterium vanbaalenii PYR-1
ZP_01203646.1, EAS24638.1
66% to CYP279A1 Mycobacterium avium subsp. Paratuberculosis
51% to 279A5 M. smegmatis
65% to 279A3 M. vanbaalenii ZP_01203523
56% to 279A2 M. marinum MM0122
MALPHSRLRTRTRLRPRDHLAVGDVHAAHAAADPDEEDAVTAAATKPSVFDAGLPTLSYDVTDTPQQIYP QFRAAQRIAPIALGPIGPEVLSYEMARTVLRDPRFVIPPGIHLSAHGITSGPLWDRVTRSILNMEGDEHR RLRSLVSRAFTPRATARMHDAIHLVVNELLDAIQDTGRCEFVAEVARPYPIPIICALLGAPREDWQLFSR WAEDIFKIVSFDCDLAEEEPVVLKAWAEFDDYIDGMIADRRRHLSDDLLSDLIRIEDGGDRLDAAELRML AFSVLVAGTDTTRSQLAASVQVLCEHPDQWALLRADSDLAMRTVEETMRHSPSMCSTVRSVTADVEVGEY TFPAGTFILVNTYAANRDHTVYDDPTRFDITREDPPPILTFGGGVHHCLGANLARLELAEALKILSHRFR
YARRTGPVPWKPLLGLSGPTSLPLEFGP
CYP279A5 Mycobacterium smegmatis
MSMEG4219 TIGR
44% to CYP107E1, 58% to 279A2,
57% to 279A1, 55% to 279A3, 51% to 279A4
40% to 107AC1, 43% to 107E1
formerly named CYP107Z1, but this name was given to
a large subfamily of Streptomyces sequences.
This new family overlaps slightly with the CYP107 family.
MTRMTVAELTPISYHHATMPAEVHDIIRQARANGPLALGPYGPEILGYEL
VRAVLRDERFEVPRGMFLAAQGITSGPLWERANNTLVGLGGPAHLRLRRL
VARAFIPKAAERLRATCVDIVTELVARCVPAGRCDVVADLAVPYAVPVIC
ALLGAPARDWARFSAWADEIFKMFSWDLGEHAEAVETAWKELDAYVDDMV
VRRRHTLTDDLLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQLA
AAVETLCDHPREWDLLAEHPELAPTFVEELMRFSPATLGTVRIAKEEVEI
AGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLHY
CLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR
CYP280A1X Mycobacterium avium subsp. paratuberculosis
GenEMBL AE017240.1
CDS 48827..50038
Name changed to CYP191A2
MDFAYDPFDAEVMANPLPYYRILRDHHPVYYMPQWDTFALSRFD
DIWRVLEVNNGTFVASEGTLPPASVLAQHNDGPVDDPPLHPLPFHAMFDADLYGEIRR
THSRPFRPRAVTDLEGRIRTLANERLDELLARGSFDLTQEYGGVVVATIVCELLGIPT
DLAPQVLAAVNAGSLAEPGVGVDTGQARPNYFEFLLPAVQRRRADPSGPPLEVVDGLL
GYQLPDGSALDDLEVATQMLCIFIGGTETVPKIVAHGLWELSRHPDQLAAVRADPQHN
IPVAREEMIRYCAPAQWFARTVRKPFDIHGQTPNPGQRVITLLASANRDEREYPDPDD
FVWDRPIRRSLAFGRGQHFCIGYHLARLEVAVLLQEWLRRVPDYAIRADAATRLPSSF
QWGWNKIPVEV
CYP280A2X Mycobacterium marinum
No accession number
Tim Stinear
MM0399
81% to CYP280A1 Mycobacterium avium subsp. paratuberculosis
29% to CYP123
Name changed to CYP191A3
CYP280A2X Mycobacterium ulcerans
No accession number
Tim Stinear
98% to 280A2 M. marinum = ortholog
Name changed to CYP191A3
CYP281A1X Mycobacterium avium subsp. Paratuberculosis
AE017229.1 CDS complement(173813..175057)
Name changed to 188A2
CYP281A2X Mycobacterium marinum
Tim Stinear
MM4717
86% to CYP188A2 35% to CYP222A1 Thermobifida fusca
name changed to 188A3
CYP281A2X Mycobacterium ulcerans
No accession number
Tim Stinear
97% to 188A3 M. marinum
36% to CYP243A1 Mycobacterium avium
formerly 281A2
name changed to 188A3
CYP282A1 Streptomyces scabies
SCAB14541
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
NEW FAMILY no obvious matches 34% to 107U1
CYP282B1 Mycobacterium vanbaalenii PYR-1
NZ_AAPF01000001.1
45% TO CYP282A1
261164 VTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYA 261343
261344 ECVQILQDWEHFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFS 261490
261491 PARMKALRPEIGVETDRLIDDFIETGSGDLAAVAWRQPGIVFFKYLLGMPVDDVPLCV 261664
261665 ELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMIDVLLSAEIDGEKLAFAD 261844
261845 VVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIRFAGSIHG 262024
262025 IPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHR 262204
262205 CLGSNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKR 262372
CYP283A1 Streptomyces scabies
SCAB56621
David Lamb
Submitted to Nomenclature committee Nov. 10, 2006
NEW FAMILY 34% to CYP215A1
CYP284A1 Nostoc sp. PCC 7120 (cyanobacteria same as Anabaena)
GenPept BAB73318
NC_003272 complete genome complement(1615917..1617470)
24% to 172A1
formerly 186A1 but that name was already given to
an M. smegmatis seq (my error).
1 MLQYITAQID NSSSFPYLVT VLSVTTIAGT FAWRWWKQKK KYKSLQSLPS PPKHWLLGNL
61 PQVLAAVKQK KLFQLFFDWS QQLGPMYVVW NGSSPVVILS KPKVIEDTIV NGMRDGSLIR
121 SARLRQAWND ISGPILIGET GNEWQWRRKV WNPEFSSSSL AKYLKIINQA CVQVIDTLKE
181 TALPKEVEVD PLFVELTMRV ISSLVLGIPV DRKITTNEGP PLEVLKVYEA MCVVGYRFLR
241 QATGEKIWMK YLPTKNSQDY WASRRYLEEF LTPRVDLALQ MREQSTDFPQ VSPLFRESML
301 VRIAAKEPKY NRQTLIAESV EFLIAGTDTT AHTLSFAVGE LSLNPRVFQK AREIVDQAWQ
361 GQDNINTESF KELAYISAIL KETLRLYSIA SGSTSLEAQR DTVIEGKVIP SGTRISWSML
421 AAGRDPEVYA NPEEFLPERW LDKSKETSSL PMIDFGSGPH RCLGEHLSML EGTMMLALLL
481 RHFDWELVNG RSSLEQLQQN LLIYPSDKMP VRFRLRN
CYP284A2 Nostoc punctiforme
GenEMBL NZ_AAAY02000016.1
complement(17366..18917) gene = Npun4356
77% to 284A1
formerly 186A2 but that name was already given to
an M. smegmatis seq (my error).
MFQQIAAQITFSDSFPYLVTALGITSTAGIFGWRWWKQKNTYKS
LQSFPSPKRHWLLGNIPQVLAAVKEKKFFQLLFDWSQQLGPMYVYWTGFP
18635 VLVLSKPKVIEDTIVNGMRDGSLIRSQRASKAWNDIGGPILLGQNGSEWQYRRKAWNPEF 18456
18455 SSSGLSKYVEIINQACEQIIEKIQSVASPEVQVDPLFVELTMRVISCLVLGIPVDKN 18285
18284 IATNEGQPLDVLKVYEAMSIVGYRFLRVATGEKIWMKYLPTKNSRDYWAARRYLEEFIT 18108
18107 PRVDLALQMREQNQTDLTQVSPLFQESMLVKIAAKEPKYNRETLVAEVIELLIA 17946
17945 GTDTTAHTLSFAIGELALNPRVFHQAQAVVDQVWESQGTINGESLKELNYIRAILKETLR 17766
17765 LYSDDS 17748
XXXSLXAQR
DTVIEGTVIPRGTKIYWSMLAAGRDPEVYSHPDEFLPERWLEKGKEN 17579
17578 SQLPMIDFGSGSHRCLGEHLSMLEGTMMLALLVYYFDWELVNGRSSLEQLQQNLLIYPPD 17399
RMPVRFRLRK* 17366
CYP284A3 Anabaena variabilis ATCC 29413
YP_324562
MLQYVTAQMNNSSSFPYLVTIFSFTTIAGTFAWRWWKQKKKYKSLQSLPSPPQHWLLGNLPQVLAAVKQK
KLFQLFFDWSQQLGPMYVVWNGSSPVVILSKPKVIEDTIVNGMRDGSLIRSARLRQAWNDISGPILIGET
GNEWQWRRKVWNPEFSSSSLAKYLKIIHQACEQVIDTLKETAPPKEVEVDPLFVELTMRVISSLVLGIPV
DRTITTNEGPPLEVLKVYEAMCVVGYRFLRQATGEKIWMKYLPTKNSQDYWASRRYLEEFLTPRVDLALQ
MREQKTDFPQVSPLFRESMLVRIAAKEPKYNRQTLIAESVEFLIAGTDTTAHTLSFAVGELSLNPRVFQK
ARDIVDQAWQSQDNINTESFKELAYISAILKETLRLYSVASGSTSLEAQRDTVIEGKVIPSGTRISWSML
AAGRDPEVYAHPEEFLPERWLDKSKETSSLPMIDFGSGPHRCLGEHLSMLEGTMMLALLLRHFDWELVNG
RSSLEQLQQNLLIYPSDKMPVRFRLRN
CYP285A1 Streptomyces tubercidicus strain I-1529
GenEMBL AY549199
Istvan Molnar, Syngenta Biotechnology, Inc.
Jungmann,V., Molnar,I., Hammer,P.E., Hill,D.S., Zirkle,R.,
Buckel,T.G., Buckel,D., Ligon,J.M. and Pachlatko,J.P.
Biocatalytic conversion of avermectin to 4'-oxo-avermectin:
characterization of biocatalytically active bacterial strains and
of cytochrome p450 monooxygenase enzymes and their genes
Appl. Environ. Microbiol. 71 (11), 6968-6976 (2005)
Submitted to nomenclature committee June 2, 2003
Clone name CypLB
Low 30% range to other bacterial P450s
formerly CYP185A1 but that name was already given to
an M. smegmatis seq (my error)
CYP286A1 Deinococcus radiodurans
GenPept AAF11281
GenEMBL NC_001263 complement(1748793..1750130)
Gene = DR1723
25% to CYP120
formerly CYP187A1 but that name was already given to
an M. smegmatis seq (my error)
1 MVPAPPFLGH AAEMGTIKLR PFLTRCYQAY GPVFQLTVPG QKITVLAGPE ANLFAMKEGH
61 RVLRSLEAWR DNDHEMGSDR SMISLDGAEH RAYRRVEGRA FARSFFAAGL RPALAVLAED
121 LAPFQPGDVL PVATWCKKTI TEQLARMAVG GTVRPYLPDL LHFIQTALQV TVNRQLPPAV
181 LRLPKYRRAK ARIFQMVDDL IEDHRQNPPE KSGRAPDLID DVLADQQVNP ERWEHPDVRL
241 AALGAFIAGM DTAANSLAFV LYRMHLHSEF LPALRAEADA LFRDGPPTAE ALGRSPLLHR
301 FVMETLRVHP IAPALSRTLT EDVEFAGHRI PAGTPVIIGT TVPHGLPELF PDPEHFDPGR
361 FAPGRAEHRQ PGAYAPFGVG SHTCAGSGMA EGLIMLGAAA ALRTLDLSLE PDYVLRQTAK
421 PTPSLDNKLQ LRVNAVRHNP VFLVH
CYP287A1 Deinococcus radiodurans
GenPept AAF12016, F75270
GenEMBL NC_001263 2469804..2470949
Gene = DR2473
30% to 175A1
formerly CYP188A1 but that name was already given to
an M. smegmatis seq (my error)
1 MLSSLHDLPE PASRPGSGHL QDWAARPLAL IEEGATQALA AGQDLFRLRL GLPAVVGLSP
61 AWNRRVLTDL NTFVSAGSFS AVVPYLAGGV ILTDAPGHGA RRRALNPGFG KGSVQQLRER
121 MRQASSPVPT GRFNALAWAD ETVRRQLNAA YFASEFDDRL LAAFLAPLRR PFPVPALPRP
181 LLFRRVEQEI RRLAERRLRE GGDDLLSTLA PLPGGLLETR ISLAAAHDTT THALAYAVWE
241 LAKAPQDQTP HTHSAVLKEV LRLYPPGWMG SRRLSRAAEW QGTEIPRGTL ALYSPYLTGR
301 DPTLWERPLD FRPERWEKSP PAWAYLPFGG GERTCLGVHL AQTLILDVLA ELPPLQAHWG
361 NDEPHPGITL GPRGPLVVER R
CYP288A1 Corynebacterium efficiens YS-314
GenPept BAC17372
35% to CYP116 82% to CYP189A2 NP_599791
formerly CYP189A1 but that name was already given to
an M. smegmatis seq (my error)
1 MIHNMETRCG SYHRATGILT GDDMTSDSTT ALSTAPETTS GGCPYGHGNP DATGTPGTSH
61 HGYEPFNMTN PFPAYEELRR EEPVMFDERI GYWVVTRYDD IKATFDDWET FSSENAQAPV
121 RKRGPQATKI MEEGGFTAYS GLSARIPPEH TRIRAIAQKA FTPRRYKALE PDIRANVVAR
181 LETMLKQGAP ADIVPALAYD IPTITILTLI GADVSMVDTY KRWSDSRAAM TWGDLSDEEQ
241 IPHAHNLVEY WQECQRMVAD AHANGGDNLT ADLVRAQESG QEITDHEIAS LLYSLLFAGH
301 ETTTTLISNC FRVLLAHRDQ WEALIEDPKK IPAAIDEVLR YSGSIVGWRR KALRDTEIGG
361 QPIKKGDGVL LLMGSANRDE ARFDDGETFD ITRPNAREHL SFGFGIHYCL GNMLAKLQAK
421 ICLEEATRLV PSLELADDQS VEFRENLSFR VPVSVPVTWS N
CYP288A2 Corynebacterium glutamicum ATCC 13032
GenPept NP_599791
35% to CYP116 82% to BAC17372
formerly CYP189A2 but that name was already given to
an M. smegmatis seq (my error)
1 MTSQTSQQST STGGCPFGHT SESTSHHGYQ PFDMHNPFPA YKELRQEEPV MFDERIGYWV
61 VTKYDDIKTT FDDWETFSSE NAQAPVRKRG PQATQIMTDG GFTAYSGLSA RIPPEHTRIR
121 AIAQKAFTPR RYKALEPDIR AMVIDRVEKM LANDQHVGDM VSDLAYDIPT ITILTLIGAD
181 ISMVDTYKRW SDSRAAMTWG DLSDEEQIPH AHNLVEYWQE CQRMVADAHA HGGDNLTADL
241 VRAQQEGQEI TDHEIASLLY SLLFAGHETT TTLISNCFRV LLDHPEQWQA ILENPKLIPA
301 AVDEVLRYSG SIVGWRRKAL KDTEIGGVAI KEGDGVLLLM GSANRDEARF ENGEEFDISR
361 ANAREHLSFG FGIHYCLGNM LAKLQAKICL EEVTRLVPSL HLVADKAIGF RENLSFRVPT
421 SVPVTWNA
CYP289A1 Brucella melitensis 16M
GenPept AAL54121
PUTATIVE CYTOCHROME P450 YJIB
31% to CYP145
formerly CYP190A1 but that name was already given to
an M. smegmatis seq (my error)
1 MRAGGIMTSP TERPKQDWDP RSEAVLSDQI GAYDAMRHQC PVAHSDYLGW SLFSYDDVVR
61 VLDDHETFSS VVSAHLSVPS GMDPPQHTAF RQLVERYFEP ERIKAFEPIC REISKKLVCE
121 LPRDAEIDLV TQFAQLYAVR IQCAFLGWPD SLQGPLLDWV HKNHAATLAR DTKAMAAIAL
181 EFDEYIRDLL DERRKLGADA PDDVTTRLLR DRIDRRNLTH EEIVSILRNW TVGELGTITA
241 CVGILCHYLA KSQQTQALMR GGPDLLPAAI DEILRLHAPL ISNRRVTTRA VVVGGREIPA
301 GEKITLMWAS ANRDEAVFDK PDELRLNRDP ALNLLYGRGI HVCPGAELAR AGLRILMEEL
361 LGQTRKLDLV PGSVPALAVY PASGFSRLPA RIS
CYP290A1 Caulobacter crescentus CB15
GenPept AAK22930
NC_002696 complete genome 1051211..1052545
34% to CYP180A1
formerly CYP191A1 but that name was already given to
an M. smegmatis seq (my error)
1 MDLISQTVVD GKAGPGAPPT YPTLKDVDLA DIFRFTKGQP WADFARMRQE APVMWHPEPM
61 GGPGFWALTR YEDVHRVNGD PETFSSQRGG ILMSMGAPEK RHALLFRASM DTMINMDAPH
121 HLQLRREHMP YFTPSYLRGL TERVKGEVTR LLDEMEPLLA NGAEIDMVEH FSSVLPLFTL
181 CEILGVPPED RPKFLTWMHY LERAQDLAVK QANAPMQPTL ELMQFVMDFN NNVEEMFEYG
241 RTMLHKRRED PKEDLMTAIA RAQLDGAVLP DEYLDGSWLL IVFAGNDTTR NTLSGAMRLL
301 TEFPDQKQKL IADPSLLGGA VDEFIRMVSP VVYMRRTATR DVEVNGQLIR EGEKAIMYYG
361 AANRDPAMFE NPDQLDVTRA NAGKHIAFGY GPHTCIGKRV AQIQLEEAYR QILARFPDLN
421 WTGNIEIAPN NFVHAISKLG VKRG
CYP290B1 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
46% to CYP290A1 Caulobacter crescentus CB15 GenPept AAK22930
75% to seawater bacterial sequence CYP290B3 JCVI_PEP_1096682145269
67% to CYP290B2 CP000449.1 Maricaulis maris MCS10
Ectocarpus sctg_1 3343594-3342116
CYP290B2 Maricaulis maris MCS10, synonymous with Caulobacter halobacteroides
CP000449.1
67% to CYP290B1
MQLVSDVILEDRPQTEPGFGATYPGFDDFKLWDPAAWTSGHPHD
FFRKMREQAPVMWQSADKSKAGYWSVTRYDDIKTVELAPEIYSSERGSINMFVMPRKE
WKPKKLIPAAFNSIINLDQPHHMQMRIQQKDFFIPRFVSELQERVDAKIDDLLDEMER
RGPVVDFVKLFSQELPLFTLCEMLGVDEADRPKIIEWMHYLELANQYFVNPWSLLSRR
PWFPIKFYHHVNAMFAYGERVMAERRANPRRDLMTAIANTEMAGKPLPQEYLDGSWLL
IIFAGNDTSRNSLSGTIRLMTQFEDQREAILSDPSLIPAMTNEALRMISPVQHMRRTA
MEDTELNGQRIARDEKVVLWYPAANRDPSVFPDPDRFDMTRENGDKHLAFGHGAHKCL
GSRIAQMQLQSAFRKIFERFPKIAWTGRQTIAPNTLVHAISSLEVNLYGRDGERPRPV
QERWP
CYP290B3 seawater sequencing J Craig Venter Institute
JCVI_PEP_1096682145269,
70% to CYP290B1
MMVGDRKLWKPEKLAPAAFNSLINLDAPAHMEMRMQQSEFFFPAYIETLRDKVEAKIDAMLDELERQGPVVDFA
KLFSEELPLFTLCEMLGIDEEDRPRIKLWMHHLELAGQFLANPWQTFLSEPMFPFRFNKVVQEMFAFGERIMKDRRANPR
DDLLTVIAQSKLEGELLPQEYLDGSWLLIIFAGNDTSRNSLSGTIRLMTEFPTQRTLVLDDPSLIPQMSEEALRMVSPVI
HMRRTAVEDTEINGQPIAKDEKVVLWYGAANRDPDIFPDPDTFNLHRDNVEKHLAFGHGVHKCLGSRIAKMQLRLAFEQI
FKRFPNIYWTGKQKIAPNSLVHAISSLKVNLYGPDARRPTRIAANK*
CYP291A1 Mycobacterium vanbaalenii PYR-1
ZP_01204524.1, EAS25516.1
MSRLSNPLHSPAFYAGDPFPVYRELRATDPVCWNDEHEFWALLKYEDIRYVSTNPALFSSARGVTVPDPA LENPVMEGSLIFTDPPRHRQLRKLINSGFTRRQVAILEPKLRAFARAALDAIDPSATEFAEQVAAPLPTR MIAELLGAPDEDWEQFRTWSDATVGMDDPDVELDTFAAMGELYQYFEAQIARRRDGTLRDSDDLLSVLVA AEVDGVRLTDQDLLQFCLLLLVAGNETTRNLVALGTLALIENPDQFRLLRQRRDLVPTAVEEMLRYASPV ANMTRCATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNPNPHLAFGCGEHSCLGAQLA RLEARVLFEELLNRFDHIELDGDVLRMQATMVPGVRQMPVRLSATAAEPRETGTAAVSV
CYP291A2 Mycobacterium flavescens PYR-GCK
ZP_01195006.1, EAS08752.1
85% to CYP291A1
MGRRTDLESP CGALHPSARI HPARTSPARQ RHRRRLGRRR ALGVPARPAR HPDRPAAHVT
PAVISAIPPV ASLAQKEIAL PPPLHSPAFY AGDPFPAYRE LRATDPVTWN EEHGFWALLK
YEDIRYVSTN PALFSSARGI TVPDPAIENP VMEGSLIFTD PPRHRRLRKL INSGFTRRQV
AILEPKLRAF ARTALDAIDP AGGTEFAERI AAPLPTRMIA ELLGAPDEDW EQFRRWSDAA
VGMDDPDVEL DTFTAMGELY QYFEKLIALR RNGALRDSDD LLSVLVAAEV DGVRLSDQDL
LQFCLLLLVA GNETTRNLIA LGTLALIEHP QQFRLLREHP ELIPTAVEEF LRYTSPVANM
TRCATRDVEM RGRLIREGQY VTMLYGSANR DEDIFGPTSE QLDVTRNPNP HLAFGCGEHS
CLGAQLARLE ARVLFEELLA RFEHIEPAGE VLRMQATMVP GVRAMPVRLR AATDPRRAKARAG
CYP291A3 Mycobacterium avium subsp. Paratuberculosis
NP_961518.1, AAS04901.1
69% to CYP291A1 = L76374
MQTHPPLRSP SFPLHSPDFY AGNPYPAYRE LRATAPVCWN DVTNFWALLK YEDIRFVSSN
PALFTSTRGI TIPDPQLPNP VQQGSLIFTD PPRHRQLRKL INSGFTRRRV SVLEPKIRKI
VRGILDGIER GAVHEFAEQI AAPLPTRMIA ELIGAPPDDW EQFRAWSDAA TGTADPEIEL
DPAVAAGQLY EYFQRLIAAR RARPRADLLS VLAEAEIDEH RLTDEDLLNF AFLLLVAGNE
TTRNLIALGT LALIAHPDQY RLLVEEPARI PLAVEEMLRW NSPVVHMART ATADVEIRGQ
RIRAGEVVVM LYGSANRDED VFGPDSEEFD VTRHPNPHIA FGCGEHSCVG AQLARLEATV
FFEELLRRYP RIELVGEVDR MRATMVPGVK RMPVRMGA
CYP292A1 Mycobacterium vanbaalenii PYR-1
ZP_01203641.1, EAS24633.1
MTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYAECVQILQDWE HFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFSPARMKALRPEIGVETDRLIDDFIETGSGDLA AVAWRQPGIVFFKYLLGMPVDDVPLCVELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMI DVLLSAEIDGEKLAFADVVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIR FAGSIHGIPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHRCLG SNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKRVTA
CYP292A2 Mycobacterium flavescens PYR-GCK
ZP_01190587.1, EAS12881.1
88% to CYP292A1
MSPTVEQHAE NWDLRHADFN DPDFLYDVYT VMRGNSPFAR TDNPFLSATP SGAWVAVRYA
ECVQILQDWE HFSSSPTPEG AEQLAGDLVI TLDPPRQQKF RKVLNPYFSP ARMKALRHEI
AAETDDLIDV FIESGSGDLA EVAWRQPGIV FFKYLLGMPV DDVPLCVELT DTALNGATEE
ARMGAWGGLY QHLHDAVTAR TAEPPRDDMI DVLLSAEIDG EKLAFGDVVS NAMLLVQAGL
ETTASAMSFA YHYLATHPAE RDRLIAEPDL LARAVEEFIR FAGSIHGIPR TVAKEVELSG
CTFSPGESVI VNYASANRDE EQFPEADRCI LDRRENRHLG FGAGVHRCLG SNLARLEFQV
GLERVLTRMP DFTLTAGAEA KFHGNSVTRG FRSVPVTFTP AARTR
CYP293A1 Saccharopolyspora erythraea NRRL23338
SACE_1376, se: 1521656,1522816 (-) STRAND
61% to CYP293A2, 39% to CYP279A3 S. vanbaalenii, 36% to CYP151A1
VDVFDRNFGYDSDTLAAARERHWYARIPNGLMVLGHEEVNDLLRDHRLVSDGKRYLEMHG
VTSGPLYDWFVPMILHREGQDHARLRSVVRRTFTPRVIEGLRPYMRETVGRIADGIAETG
ECEFVETLANPFPVMVMGRLLGVPPQDHELFHGWSTDVGLVFSLAYGGDVRERVERAVSE
LGDYFDGLIERRRAEPADDLISSMIAAQTEEEVISGEELRNLLVALVSAGHDTTRHQFGS
AMLTLCRNPEQWTAFRDDPDRAVEEILRWCPAAPVLFRFAQEDIAYRDTTIPAGTFVMLC
VHTANRDPKRFDRAEVFDTTASRQTPHLTLSAGPHFCLGAAAARAELSEAFTVLSTRFGA
PRIAGEVTWRNPVGIYGPETLPVRFV
CYP293A2 Saccharopolyspora erythraea NRRL23338
SACE_3308, se: 3655951,3657162 (-) STRAND
61% to CYP293A1
MPTSIESASQAPFLDVTDPGFTFEAPEVARARERHWYARTPVGPIVLRHAEVQELIRDPR
LAQDGARYLAMHGITSGPVHDWFVPLILHRNGVDHLRLRRVVQKSFTPRVVNNLRPFMRA
TAERLAERIAAEGACDFVEMFADPYPVAVMCELLGVPPQDYELFHRCSTDIGLVFSLSQG
DGVRERVERGVVELYAYVDSLIARRRAAPTGDLVSRMISAHEDDARLSSEELRNLVVALV
FAGHDTTRHQLGRAMVALCAHSEQWTALREEPQRAGAIVEELLRLFPTAPVIFRFATEDL
EYQDTAIPAGTFVMLCVQSAHRDVRAFGPDVESLDPAAERGAAQMVFGGGPHFCLGAATA
RAELAEALPVLARRLGAPAPAGPVAWRHPIGIYGPESLPLRFG
CYP294A1 Saccharopolyspora erythraea NRRL23338
SACE_2631, se: 2876305,2877468 (-) STRAND
41% to CYP107N1
MEQASTGQLGPLPEFLRQATDEVERIVAPSGDKVLLVRGYALGRQVLTDKRFSRAAAVQP
DAPRFNDAQPVPDSMMSMDGAKHARLRRVVAGTFTTGRVSAMAPAVERLVDEHLNRVADI
GPGADLVEELAAPLSLSVLCSLLGIPLDDSARFREWVEVLFDITASTPREKARHRLELIG
YMTDTIEQKLQRQDDDLLTTLIRAHTQGKMSRPELLTLGLTLLMAGYETTAGQIGLSVLS
LLSDRETHDELRAHPELLPDAVEEFLRLTPATPLSFPRVAVEPVELNGVTIQAGEAVVVS
LLHGNRDTEVFAEPGQLMLRSRDAVHLTFGHGVHRCLGAPLAKLQVQLVLGRLLERFPAL
RLTPGPDSVVWKDGLATRGLSRLRVEW
CYP295A1 Saccharopolyspora erythraea NRRL23338
SACE_2082, se: 3065572,3066867 (-) STRAND
26% to CYP171A1
MLGTRTVRPPGPKGRWLVGNTLDYDRDRMAFLVRCRQEYGDVFSFDERTIVVLDPGLVHD
LLTRTNDDFHSESVPLATRIDPERAAADAQAWMTARRKGWHGLNRAVAQAHAGRLRLLFE
QTLAETRGETVDVLPVMERFAGLATADFCLGADADGMAEILTENVRAIEPLGGSSQLFPA
WWPSRHIRRFLRAREGTLNAVTERIHRRRDKPPADHPQDLLDVLLAAGEPELTEQQVQLL
LRGIMLAAFGVPATALTWLVWTLASRPDLHRRVAEEAAAWPGEEAPPLSALPQTEAVVKE
VLRLWPPTWLIGRTARRGTTLGEWQLRPDDHVMFSPYLMHRDPRWWTDPDELTPDRWLDP
ARTPKRHTYIPFGAGPRVCVGTQLGMIQLCLAAHWLTRNHEIRPTTETCAPKFHDLLLPQ
GFRARFTPRTP
CYP296A1 Saccharopolyspora erythraea NRRL23338
SACE_4818, se: 5381779,5382957 (+) STRAND
38% to CYP107X1
MLEQDVLDEVTNPFPGLAALQEQTPAVRVRTPDGPPAWLVTRYADVRDLLRDDTRLSVDP
DHGAGEDYAGFELPPQLRPHLLAVDAAQHDRLRELISSPFTGTGLHRTVEVVEAEAHRLV
AALAPDQPVDLVAELAFPLALTAVRAVLPLPDPAHQAFAEWAHDALLAPRRQEDGAEVRA
RDTLGRMAEIIQTATTVPGDGLLGELQAAYHHGRLSAHELAAQVFYLLFVPTEPLVDAFG
VVLLRLLAGTRHRAVLRDSPAARHVAVAEALRFDTPQGLAAPRFALVDLDIDGVRVRAGQ
TLLLSLAAANRDPRQFDDPDELVLTRSPNPHLALGRGDHACPATALSYQLLSSSVAALLS
RYPSTTVVPEKTQWRGNFRHRGPASVWADLKP
CYP297A1 Saccharopolyspora erythraea NRRL23338
SACE_5461, se: 6115384,6116697 (+) STRAND)
38% to 102C1 (I-helix to end)
MAGPVLSSSDIPGPPPSAGGHNLRDIAEAGGLPGFQVRLHRTYGEIAHFAMPNAQVVSVA
SPEVLESTLDLPECPMELAPFLTPLADAANVLLSGEQDRARWRRTVIPALSCPHRAESDH
PRFIDIIEESAQRWSSTGEPVALERELDTLALRLMCTSVLGSTPGQAAIVERVTDAFERL
PEFFLGQVYGVRTTSQEPAVDSALTTLRDVVTFLVDEVAPSDLISAARRAGQSSKDLVNT
LLAILIGAHRTTGTVVSHALRQLMRHRDVAKRLRAELKTVLGGKAAPAFHELPCLRYLRR
TLNESVRLASPVPGIARRAPDGIALGAYRIPAGTVVHYAIRAVHMNPRVWPRPDEFDPDR
FDTAPQNSRPAMAFVPFGIGRNDCPGALVAMEHALLMLAVLAHRFRFESRTAGKQGSRFS
LGGPCADPVRVRPRRSR
CYP298A1 Saccharopolyspora erythraea NRRL23338
SACE_6112, se: 6855037,6856212 (+) STRAND
34% to 107X1
MSVPTAVGAACPGEVFDPLSPSMLADPYLVYERLRTEAPVHWHEHLRAWVLTRHEDCVGV
LRRPEVFGSDPRKLAKPIPESVISLQTMDPPEHSAVRHHFLAKLRRQDLDAWSARVRRIA
VELLSNAGPDPFDFVAEVAEPLALHSMCSLCGVPYPEDDERFRTASRTMVLGMDAGLEPA
RREPALAARGVLNEIIEDWIARAPRESLISGLDEVSGIERGYLVNSARAVFDAGYSTTGN
MLGNIVKWLLGPGGVRETAPLGGLDSRAVEELGRIEGVVQAVSRHCLAAVEIGGRTLRRG
DVVIVMLAAANHDPKVFPDPRRADFSRESGPHLVFGRGVHSCLGGHVAGRVALALLHALA
DGFERIEPAGPHRQRPTATQRGLDHLPIRLS
CYP299A1 Natronomonas pharaonis DSM 2160 (Euryarchaeota; Halobacteria)
CAI49361 GenPept, CR936257.1:1230684..1232030 genomic
YP_326920 GenPept, NC_007426.1:1230684..1232030
1 MSTRLPEPPE AGLLNALRFG TDTFRFLEGI QARFDDGTSV SIPGRPPLVV LTGPDLVGEA
61 LDRPEDFPRV PAQDAVTMIA ENGLVQSEGA LWSQQRSVMA PSFSGEQVTA YANTTGRRIE
121 ARADQWAAAG ARTTDLHREM TSLTVRVASE ILLGEDIGTE RADQFHEWMQ VAGEEFEFGI
181 ETVLPDWVPT PTSGEFEQAA AGIRELSEQL IERRRESLAA GERPDASDML TMLIRAEDNP
241 DIDYPENQIR DEVATFLIAG HETTALSLTY TLCLLSWHPE ARRRVRQEAD EALGDGPPTH
301 DDLAELTYTR RVYDEALRLY PPAWGVFRQA NGDVTLGQYT IPDGSAVIMP LWSIHRDGSY
361 FEQPDTFDPD RWERRTPRAV DAYRPFSSGP HACIGRGFAL AGSTLVLARL VRDFDIDVPE
421 SALDDLRLTP TLRPADGVEA TIQPVGGR
CYP1001A1 uncultured haloarchaeon FLAS10H9 (Euryarchaeota; Halobacteria)
ABT17365 GenPept, EF558547.1 4383-5705 genomic
58% to YP_135740 Haloarcula marismortui
1 MTRAPHTPPG PPVVGNVPRF ADDPLRFLVG VQEAYGGQYP VVRLEPAGGQ RIVVILDAAL
61 VHEILADRER FVRPRAGPEA SRREGLLSSR GPLWERQRSV IQPELVGGQL AAYADIAARS
121 VEEMLDRWPE NGEIDLVAEL SMLTMQVIAR SLLGRDATRE QARTVYEALD TFAEEFEFGA
181 DALLLPDALQ SGPSAAFERA DADLEAVARD FVDWQREHED PPDSMLTALI EAERDGVELS
241 EDELIDQTVL FLTAGQETTA LTIAYAFHHL SRSPDVRAGV TEEATGVLDG AAPSWEHLSG
301 FDLTERVVRE TLRLTPAAWN VTREVRGPTT LGGTRFETDD LVLLPTYAHQ REDRVWGDGD
361 AFRPARWTDE VSRSHDSYFP FGSGPRVCIG RQVALTEAQF TLAHTLQQYE VDVHGDELAF
421 EPAITLRPAD GLRATVTERE
CYP1001A2 Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)
YP_135740, AAV46034 GenPept, NC_006396.1:957294..958619 genomic
58% to ABT17365 uncultured haloarchaeon FLAS10H9
1 MERTAHTPPG LPVVGNLPRL ARDPLRFLTG MQDAYANQYP LVRVDPQVGQ SVTVVLDPDI
61 AHEVLADRDR FRRPNVGAQE QRRQGLVSSD GALWEQQRSV LDPEFVGGRL ADYAEIAGDT
121 LEETLTAWPE SGRVDLFEEL SILTMRVITR SLFSQDTDRE RGETVHEALA ALNDEFDASV
181 FDLVLPEQLQ SGVSAEFEEA DAVLDSVATE FVDWHLNHED PPRDVITALI DAKADPDIEL
241 SENELIDQTV LFMTGGQETT ALTIAYAFYW LSQNPAAKER VRAEAQDVLD GGQPGWADLS
301 DLTYTERVVR ETLRLTPAVW SVSREAREPV TLAGTDLDAG EFVMLPIYAH HRDSRVWSDP
361 LTFDPDRWAG SASRGDSAYY PFGSGPRVCI GRQVALTEAQ FALAHVLQHY DVQVTADELD
421 LQPSVTLRPS GPMEAEISAL E
CYP1002A1 Halorubrum lacusprofundi ATCC 49239 (Euryarchaeota; Halobacteria)
ZP_02015811, EDN49875.1 GenPept, NZ_ABEB01000002.1
complement(438766..440292) genomic
1 MCNPITRSDD DRARQSGGSE RTDTADADVD VADAPPPPDP GGLPVLGNVH ELASDALGFY
61 ERRSAEYGGI VRYDVFGTES YLVTDPGAIG RILVEDHDRF VKGEMPREQL GGLLGDGLFL
121 AEGEAWREQR TAIRSAFFRE RVAAYGDSMV EHAREAVDSW GDGAVVDVHA ASTEYAFAVL
181 AESLLGSDIE GERETVRAAA EAITDRFDMS RPTSFLPEWL PTPANRRYRR RLGALRATIR
241 DLVTERRAAG PPADPSAADD LLGTLVAAAK LGALDDEELV DNAVTFLFAG HETSALGLTY
301 ALYCLARRPA FQDRIRSEIA PLHGDPTPAD LRECPALTAA VDEALRLYPP VHSFFREPTE
361 PIALGEYRIP SGVVLTLAPW SVHRDGRWWN APETYRPERW LRETEDGGVV HGDDRSGPAV
421 GEHPEHAFFP FGGGPRHCIG MRFARQELRL AVATILRRVR LEPVTEELSL QASANTRPDG
481 PVHVRILTRD EPSDPESLDQ DEPSKTSW
CYP1002B1 Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
ZP_04000149, ABTX01000002.1 262288-260948
49% to CYP1002A1 Halorubrum lacusprofundi (Euryarchaeota;
Halobacteria)
1 MSTEGGYPPG DGGLPVVGNT VELSRDILEF YEGLRNEYGR IASYRVFGTD ACMVADPEAI
61 RQILLEDHDA YEKGDVLTRS LGDAMGDGLF LSAGEQWHRQ RTRMQPAFYR ERLDTYVPAM
121 RDTASQSLDD WHDEAVIEVN DAMTAMTIDV LGRTLFGVDV ADEPVVTDAS DAILARFDTN
181 RFWSFLPDSV PTPTNRRYRR EIERLREFVD GLADQRRRRP REERGDDLLS ILVGFVESGD
241 LTMSEFRDNL ITFLFAGHET TALGLTYTVL CLARNPDEQE RIRAEVDSVC DGSVTAADLP
301 ELEQTGRAID EALRLYPPVY LFFRETARDV KLAGYRIPNG TTLVLSPWVV HRDSAWWDDP
361 QTYRPDRFAG ESDRPEYAYF PFGGGPRHCI GMRFARMEMK TVIASILRRY EFELVSDPDP
421 ELIASSNLKP AEDIEIRVSE RASTTSN
CYP1002C1 Halorhabdus utahensis DSM 12940 (Archaea; Euryarchaeota)
ZP_03870570
46% to CYP1002B1 Halogeometricum borinquense
1 MAETQGSSTE RGEQPSETPP GPGGLPLLGN TLDLYRDPWA LYEELESYGD VVHYTAGGND
61 FNVVLDPTLV EQVLLTDHDA YGKWALGDVG GGIGSEGLVL TEGEQWQRQR RVIQDAFTMD
121 RIRAYGDAMG QYAAEAVEAW DDGEEIALNE AFSRLTLRIL AHSLFDLDID AEAGTVAEFT
181 RTVNDRMDVD NLTAFVPLWV PLPRNRRFKR RVAAFESFVE ELIEQRRADA TERDDLLSLL
241 LAHEGDGLTE TEIRDQMTTF LFAGHETTSL ALTYACMALA THPGPRERLN REHERVLDGG
301 IPSLAQLPQL EATERAIKEA LRLYPPVYVL FREANRDVEL GGYRVPSGQK VTVPQFWIHR
361 KEAFYDDPDE FDPSRWTDGF EDELHDYAYF PFGGGPRHCI GMRFAMQELK TVLPTVLQRV
421 DFELLSDPDP DFSMGATLRP AEDVRVRVRK RD
CYP1003A1 Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)
YP_137709, AAV48003 GenPept, NC_006396.1:2929400..2930776 genomic
1 MDTQQAIRET PEPVTPGDRP PRLGRVPFVD NTAAMLRDPL GFYDRAGAHE ADMVGYSVAG
61 TTGCFVCHPD LVEQVLVTDA DVYEKGQLLQ DTLGQFIGEG LFLLEGEEWQ QQRTALQPAF
121 YRERIAAYGD TMTEFADRAA AGWSDGQRID VLPHMQSLTL NILGKTLLDV DIETTADALE
181 PLLDALRTRL DPRSLSAYLP LWVPTATNRA VTNSLAEFQS TLDDVIAARQ REDEHAREAR
241 DDVLSLLLSL DDETMDRERL GHQLLTFLVA GHDTTALTLT YAWFLLANNP KRQQRLHDEL
301 DATLGERQPT PEDLFELPYL DAVLNEVLRL YPPAFTVFRQ PTEPVTLGGY ELSTDAQLTL
361 PQWLVHRDDR WYDAPDAFRP ERWDDDLEAS LPDYAYYPFG GGPRHCIGMR FARMEAKLAL
421 ATIAQQYAVE AVTEPPLSLA MQITLSPTAP VEVRLRER
CYP1004A1 Salinispora tropica (marine actinomycete)
Strop_2825 complement(3240153..3241445)
45% to Strop_2829
39% TO CYP107AQ1 Saccharopolyspora erythraea
36% to CYP107P1 AL049754.1 Streptomyces coelicolor
MSTFSLERVACDRMLGLAVRGRLADSLLMRANTARPHLSAAFLATKDDPYPAYAELRARG
PLTRAELGQWLVTGHGAVSALLRDGRLESRMPAEYTRLTLGDSPGVDFLHRIVLTRTPPE
HTRLRRFIGRALGTPVVRRLHDRIAAATDALLEPALDRGRLDVVTELAVPLPVGVVCDLI
GIPTGDRPAVLTRVTALAKVFDAANLSPADLADINTALPWLHDYFGDLLAVRRAGSGGPT
LTEMYWEESASDRLAVADFVDNMLFLFHAGFETTMGLVSNGVAALLNNPEQLGRLRADPA
LVPSAVEEFLRYDAPIQNVIRVARKPVEVAGQKIRAGRTVLLLLGAANRDEEVFADAERL
DVGRDPNPHLGFGGGLHHCVGTALARLMAVVVFERLVDRVTVLGPAAPAVRRRHASLRSY
DHLPLAVAAR
CYP1004B1 Salinispora tropica (marine actinomycete)
Strop_2829 3244612..3245814
45% to Strop_2825
39% to CYP107P1 AL049754.1 Streptomyces coelicolor
MTTSALAPRFDALDPNVVEDPYPEYARLRAAGPLCRLGPGSWGVTRFADVTNLQHDPRLG
SEFPAGYHEISVGDGPASAFFQRVMLYRDPPDHIRLRRLMSGAFTPAVVRRLRSHIEDLV
DELLAPALAAGRMDLVPELAYPLPVRVVCRLMGIPPESTEDVRHHATNIGRAFTAVVPEQ
ARTEADEAVSWLREHLGALLEQRRSHRGDDLLSRLLDAEESGDNLSADEIVDNTVFSFFA
GFETTVHMITTGTAALLAHPDQLARLRADPSLVTTAVDEFLRWDAPIQGTARYVREPIEI
GGRTIRRGRVLVLMIGSANHDERRFAQPDRLDVGRQDNPHVAFGGGAHLCLGAFLARMEG
AVVFDRLARLAVLEPDGPTVREPNTPFRAYASVPVRIGDR
CYP1005A1 Salinispora tropica (marine actinomycete)
Strop_1572 complement(1785780..1786949)
29% to CYP116B2 Rhodococcus sp.
53% to CP000481.1 Acidothermus cellulolyticus 11B
MSAVLFRSWTKTAGTHWPAITRVADQQGTEHLVVTQHALVRQVLTDQLTYRPDNALDAVT
PIPVAALRVLAGHRFRLPPTLANNGGVSHPAIRALVADALHPAKVAAQRPWLTGLVAERV
AAIRRTLDSGGSTDLHAELNADLPLLVLARLVELPDAPVSAVKQFARAALELFWAPLDAD
RQLALADEVGRFHQVLREFADTGGGLAAALRATGHPPDVLVGALFFLLVAGQETTSQFLT
LLLHRLADEPTVRAALRADSVSVADVVEEGLRLEPPIVTWRRVAAVDSTLGGSTVAAGTS
VLLWLARAGRDPAVVPAPDEFRPGQRGSRRHLAFGAGAHRCLGDQLARMEAAVVVEQVTP
LLDGVTVVRPPWYPDNLTFRMPDAFVVRR
CYP1005A2 Acidothermus cellulolyticus 11B (Actinobacteria)
GenEMBL CP000481 REGION: 1144006..1145259
53% to CYP3005A1
MSGATDAAERETEILYRDWYATDPRRPVIRVGRHWLVSSRALVK
AVLLDQETFAADNTLDAETPMSVAALRILAGHRFRLPHTLANNSGPSHAGWRRLLAPY
FSPSAIERHRAYVDRVAEQLVAEAAAVLARDGVVDLHAAVSQPLPLVVLDRIIGLPPD
DIATVKRFAAAALELFWAPLTPERQRVLADQVGAYHARLRRFAQTAGGLGAELRDHAQ
RTGLSDDDVVGVLFFLVVAGQETTSQFLTALFARLLAEPAVLAGLRRGRIAVADVVAE
GLRLLTPVVTWRRVATRDVVLGGTTIPRGGSIVLRLAAAGRDPDEVAEPEHFLPGQRG
SRRHLAFGAGAHRCLGAQLATMEAEIVVTRIADLLAEAEVVRAPRHPLNLSFRMPDAL
VVRSAAVSAGVAPAGGSCRGRSRSM
CYP1006A1 Natrialba asiatica (Euryarchaeota; Halobacteria)
BZ895753.1 GSS sequence
42% TO CYP205A1 Chloroflexus aurantiacus
WRYAEDVARALFGVDIDDDVETVGSALDEFMLATESLSHMMLPPRVPTPSRRRIQRARES
LDAVVYRMIEERRANPTDRDVISKLLEVTDEDGTKLSDEQIRDEVVTLLLAGHETTALSL
TFTAYLLATNPAAEERLVDELDDVLGGETPTMADLDDLTYTEQVVEESMRLYPPVPGIVR
EPAKPDIIGGYEIEPGATVRMHQWGGPPRP
CYP1007A1 Lyngbya sp. PCC 810
ZP_01623228 6
MLASAADQAEFIDLGVKKMTTIANQKAWTIPGPSPLPLVGRIVNTINFAKDSIGYSSELFKTYGKVASIV
AGGGTNLYSAASDCPGTVIAYGPEIVRQVATQSHIYHKAPLSGILYRYKDVSERTKPLKNYGVGLFGVND
ETHLKQRKLMMPAFHHQQLRSYRDDMVAITQSELEQIKVNEPCEINQLMKRLTLRIATQSLFGEDVIEKD
HSAGNLLQEIISIQISPFTRLLPLDLPGFSFHRYLDLLSLFETQMKGIIAEKKAKTTPDSDVLSMLVKAR
YEDTGHLLTEDELIAHTGVLFLAGHETTANALTWILLLLSQHPQVCSDLFDELDSTLHGNSPSVEQLQKL
PLLERVIKESLRVITSVPWNGRVTSQTTELGGYVLPKGTEVFVSIYHTHHLPDIYPDPEAFNPQRWESIN
PSVYEYNPFSAGPRLCLGAAFAMMEIKIVLAMLLQRFRWEYLPVQKIDRNGFISIKPKFGMQMKVCSQDR
EFMHGVGSVEGNVREMVKLPS
CYP1008A1 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
56% to seawater bacterial sequence CYP1008A2
Ectocarpus sctg_1 2052003-2053223
CYP1008A2 seawater sequencing J Craig Venter Institute
JCVI_PEP_1096696260773
56% to CYP1008A1
MMSETNQAAIGDWVGADFFDPSFRDDPYPKLAHLRENDPVNLTPVGTWRISRYEDVKAVFNDAPTSMTDKLGDSPNFDP
LDTKGSFLEFVLNKDGDAHRRLRMLVQKSFGQKTVRLMEEEVAKTVAAAFDKAQADGGMDVVPALAHEVPSRMICQIMGV
PMQDRQIFNEWTAARTNAFFAKFLPPDVQERTRNAGAAMEDYFRALIAERKRDLGDDLLSSMIMASEGGDKFTDDELIIQ
AIGVIVAGYETTIGLLGNGTRAFVEHPDQLAKLRNNPELVSNATDECLRYDTPILFNWRVLEEPYELSGVTLPAEAVIWQ
LLGAANRDPARFADPDQFDIEREDVAHQSFGGG
CYP1009A1 Ectocarpus bacterium
Genoscope Ectocarpus siliculosus brown algae project
A bacterial genome was found with the Ectocarpus DNA
58% to partial Metagenome sequence AAFZ01017524.1 CYP1009A2
Ectocarpus sctg_1 2103615-2102353
CYP1009A2 Metagenome sequence,
AAFZ01017524.1
microbial mat from gray whale carcass in the Pacific Ocean
34 NQMDALDNTYRALVHRAFSRRTVEERRPRIVEVVNGLLDAASAKG
170 LFDLVHDFAFHVPIIVASEIIGIPTDARELFRAAFEKSAGLMQPKRDEESWAESLDAA 343
344 RWIGRYIKGLIAERRASPQDDLITGLIRAEEEGDRLSEAEMSSAISTIYTAAGTTTERFI 523
524 SSGIFILLSHPEQWRALVADPKLLDGAIEEILRFHHPMQSTSNNRRCTVDTPLG 685
682 GRQLIRAGDTIRVGLGAANRDPAV*SDPDTFNI 780
CYP1010A1 Parvibaculum lavamentivorans DS-1
CP000774 (genome) ABS61705.1 (protein)
CDS complement(82741..84153) locus_tag="Plav_0082"
37% to CYP205A1 Chloroflexus aurantiacus (eukaryote-like P450)
MAMRAERFDEEAPEIFIPARPVPPKEAPGIGAAVFRPQLLANLIASYPEFWYSARSCPFRVGIARGGRGM
LVNDPDAIRRILVSDAEHFPKDDNQLAILKPLLGNGLLTAEGATWRRNRKLAAPIFQHSSVRDFAPLFVR
AAERSARRALEQQGFFPLDREMTKLTLEIIGETVLSANLEDDIDGISHTVTSVLDKFPAMFLASAFLPGQ
LRNRVIDTVVRPGRRALDVFARRIIDEARKSGEETTLLQRLMVSQSKAGHEMTLDQVRDEVATFLLAGHE
TTATTMSWVWYLLTVHPEWQERLYEEVWAVTEGRRLTIDDVPALVETRAVIEEALRLYPPVANLMRRAIK
TTELTPDITIERGQTVLISPWLLHRHRFFWREPDRFDPTRFLGEEAATRPRHLYIPFGGGPRICIGASFA
LLEAVLILATFMQRARVKVINADQVMPQARIVLRPNVALQAVVTPRRPGG
CYP1011A1 Crocosphaera watsonii WH 8501
ZP_00517718
similar to CYP107 family
46% to CYP149A1 Microcystis aeruginosa C-term
note="In CYP149A1 the amino acid residues 2 to 200 are similar to
polyketide synthase
The amino acid residues 217 to 502 are similar to
cytochrome P450.
45% to CYP1011B1 Gloeobacter violaceus PCC 7421
MTKTKKNKTQNKLVFNPFYRAFHNNPYPIYERLRNEDPIHWSFLKAWIITRYQDVDTILKDNLFQVDDLP
LRLEEKSAYLKQGNFLPLAKTIDKWLFFQQPPNHTRLRSLVNKSFSPASVGNMKEEIEAKVNHLLDKVIP
TGKMDLIDDLASPLPAMTVTNILGLPPEDYYKLIHWSYELFFVFDQPMSLEGYEKQNKMAMEAREYLLRF
IANIDENSQGLIADLVKAKDEENKLDEDEILGFCIMLLIVGQETTKSFISNSILALLQHPEKLQELKDNP
EIIKEASEELLRYDTPVQVIARLAREDVEIGGKTILKGDKVILCLGGANRDENKFPNPEKIEFQRSNRNL
PFGGGIHFCLGAFLARLQGQISINRIVQRLPNLQLVNQTPDWRESITLRGLKSLPLTFDKNDIKTD
CYP1011B1 Gloeobacter violaceus PCC 7421
NP_924888
similar to CYP107 family
45% to CYP1011A1
MDSVANLNQDAFGNTLPQTEAPFKFNVFDPAFHEDPYPFYDRLRRESPIYRNFMGAWVFTRYSDIKSILR
DRRFRVLDKPGWIKNKNRYLTPDQGNFDALVRSSSKFFFFLEPPDHGRLRGLITKAFSASFVDRLRPHVE
ATLADLLGKVREQGAMDIMADLACPLPAIVIARLIGVPAADYARLGHLSDELARIFDPVISLEGYLHLNA
VVEEFGSYFLDLVAEHKRQPGTDLIDSLIAAQEEGNRLSEEEVVAVCMQLFAGGEETTVNLIGNGMLALL
THPEQLELLRSKPEIIAGAVEELLRYDSSIQLVARAAIEDIEIEGCTIGAGEHVHLYLGAANRDPAQFFD
PHSLDLTRVDNRHLAFGDGIHHCFGGPLARVEGQVVFQTLVQQFPKLRLAESRRPERREGTLLRGLKTLP
VTF
CYP1012A1 Streptomyces peucetis
No accession number
Pramod Shrestha
Submitted to nomenclature committee May 16, 2008
Clone name SP_7691
CYP1013A1 Streptomyces peucetis
No accession number
Pramod Shrestha
Submitted to nomenclature committee May 16, 2008
Clone name SP_1171
CYP1014A1 Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
ZP_04000645, ABTX01000007.1 36825-35530
38% to CYP174A2, 37% to CYP1003A1
1 MGDNGPPTPG GLPVLGNTVA FARDPFSFID SAVTTHGDVI RLSMLGRDRY IVAHPDLFER
61 ALVTDRDAFV KTEDFRLAFG DSVLAVDGDE WREQRDLLDP FFFFRQITDY IPKMRKQADR
121 RAESWTPGQT YSAVEEMKGL TFDILGSTLL GQDPGKRSGD DSLRRAADDL NAYFAPTSWA
181 LPGSLPTPSR RRFNRAVTTL REEVDRLLAA DHSGDDLLSV LAEARGEEGY PRSETAVSDQ
241 LVGIIFAGHE TTALALTYTW YLLSEHPSVR ERVEHEIDEV VGDDPVGAEH LSDLTVLERV
301 IKESLRVYPP IHTLPRTTTR EIELGGYSIP EGSEVLLSVR NVHRDERFFE HPDQFDPDRW
361 ERNDAPEYAY VPFGAGPRRC IGQSFAMIEA KTALTELMKR YRLEWAGNGE LDLSPQMTTQ
421 PRGDVPMIVR ER
CYP1015A1 Natrialba magadii ATCC 43099 (Archaea; Euryarchaeota)
ZP_03692266
39% to CYP1003A1
1 MTDPQSTADD RSPRTDAEAG TEPARNDGET GSMRATARTP PPGPRGLPLI DSTLTFVREP
61 LEFLSDLSTY GDVAGYEAFG REFVAVSDPG LVEEVLVSRD DEFWRGEFEN EFSDAVAIEG
121 VFFAEGDRWR RQRVLLQNAF TPARIQSYAD DMVDETTRLV ERWSDGDVVD LREASSTLTL
181 RALTRSLFDL EFGDDRAERV RRWVHAMGVY NDTEFFGVRA VLPTWLPSGA EREYRRATAD
241 VEALVEGLVA DRRQSGTDGD DLLSLLATGA YPDGSRPSAE EITDQLLLFL LAGHETTATA
301 LTYACWLLAG DDADVDVDAD IDADADAGAD FDVDVDGGAD ADADFDTASV RSQLEREVDA
361 VCGDRNPTFT DLPELSVTEA VSREALRLYP PLPFLQREPH ESTAVGGYRI DPGTTVQLNM
421 YGIHRDDRWW SEPDAFRPAR WLSADEDGRP VLDARTDTNR PEYAYFPFGG GPRHCIGMRF
481 AMTELQLSLA TLVQHADFDR ITESIDPSFK VSLDPGPVEM RVRKR
CYP1016A1 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0162
36% to CYP150A9 Mycobacterium vanbaalenii PYR-1
35% to CYP150A5 Mycobacterium marinum MM4737
34% to CYP194A1 Bradyrhizobium japonicum
CYP1016A1 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000115.1 3646-4842 (-) strand, EFG78513.1
4 aa diffs to CYP1016A1 Mycobacterium indicus pranii
CYP1017A1 Sphingomonas wittichii RW1
GenPept ABQ67388
MSGSRDIDHH AVAFARDHLA IYRDARAHCP VLRSDAHGGF AILTRYADNR AALRNHDTFA
SGRIRAGDRL GGGVAIPPNG LRIGMIEMDG AEARALRALL QPWFTIAAVE AAAPRMAQLS
AWLVDRIIAR GACDVVEDLA KPMPSLLILD ILGLPLDRWR DYGRVLHEAV AKSSGSIDGL
RWLASDLRAS VERREVHPEG LIAAMIAAEV DGRPLGDALV CELAMMLLFG GTDTTIAAIG
HALRHLTEHP ADRAALVARP ALIPAAVEEI LRLYSPSTGV ARTVTAPVEI GGERFEPGQR
VLCAINSANR DEEMFADAER FDLDRPKRPH LAFGWGVHAC LGQNLARADL RILLGELLAR
MPDFAVDVAA SERYASIPLV NGHARMPMRF TPGTPAGTGG GELPILTAPR LRPLP
CYP1017B1 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0161
45% to Sphingomonas wittichii RW1 CYP1017A1
37% to CYP188A3 Mycobacterium marinum MM4717
33% to CYP222A1 Thermobifida fusca GenEMBL NZ_AAAQ01000022.1
CYP1017B1 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000115.1 4886-5812 (-) strand
95% to CYP1017B1 Mycobacterium indicus pranii
CYP1017C1 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000109.1 13577-14839 (+) strand
46% to CYP1017A1 Mycobacterium indicus pranii
CYP1018A1 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0241
52% to CYP1018A2, 40% to CYP1018B1
32% to CYP239A2 Pseudomonas sp. KIE171 GenEMBL AJ311159 4194..5354
CYP1018A1 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000109.1 29026-30219 (-) strand
100% to CYP1018A1 Mycobacterium indicus pranii except
the end that seems frameshifted in the pranii seq.
CYP1018A2 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0283
52% to CYP1018A1, 41% to CYP1018B1
32% to CYP194A1 Bradyrhizobium japonicum USDA 110 GenPept BAC48170
CYP1018A2 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000108.1 3707-4894 (-) strand
98% to CYP1018A2 Mycobacterium indicus pranii
CYP1018B1 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0281
43% to CYP1018A2, 40% to CYP1018A1
31% to CYP194A2 Rhodopseudomonas palustris NZ_AAAF01000001 gene
= Rpal3007
CYP1018B1 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000108.1 6175-7389 (-) strand
97% to CYP1018B1 Mycobacterium indicus pranii
CYP1019A1 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0272
53% to CYP1019A2
34% to CYP194A2 Rhodopseudomonas palustris NZ_AAAF01000001 gene
= Rpal3007
CYP1019A1 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000109.1 3763-4911 (-) strand
97% to CYP1019A1 Mycobacterium indicus pranii
CYP1019A2 Mycobacterium indicus pranii
No accession number
Submitted by Vikram Saini Oct. 7, 2009
Clone name MIP0295
55% to CYP1019A1, 34% to CYP1018B1
33% to CYP194A2 Rhodopseudomonas palustris NZ_AAAF01000001 gene
= Rpal3007
CYP1019A2 Mycobaterium parascrofulaceum ATCC BAA-614
NZ_ADNV01000107.1 7908-9115 (-) strand
98% to CYP1019A2 Mycobacterium indicus pranii
CYP1020A1 Frankia sp. CcI3
YP_481145.1
ABD11416.1
not like alni P450s same as ABD11416
31% to CYP211B1 Salinispora tropica
MRNTAPRASKGPNQLLTTLLATLPRPDPFPLYAELHQQGESFRSPLGTVYLVSHARCSESLRDPRLAVED
AALRARHRPGWADEAWSPFFDSLLFLNGADHRAVKTVAQSLLVPRALRLLEEGLETATDEVLGALAGAAK
AGEAIDVCHDVAWPLQLYTLSTFLGVGPGELDFLPGLMPRLVVLGSPLMWHSADDAKHAAEASRTLVAFF
KRIIEQRSELAARLGARWEHGLVHRLLASADAGGLDTSDVLATLVAVVVAGVETTIGLIANAVVEILRDP
RGTDFGDLRGPDSTPFVEEVIRLAAPIHIVGRRALESGTVVAGHEVPAGAHVVLLLGAALRDPAMFPEPN
QIDPTRAAGSSLAFGSGPHYCLGAALARIQLRAVVGGLFTRYPQLRLSGEPQLGRHLNPHSYSSVPVLLA
CYP1021A1 Frankia sp. EAN1pec
YP_001506746.1
ABW11840.1
44% to CYP107D1 Streptomyces antibioticus
MSVTETVPQDQDQDLPSFPFPDTFSPLPSGTLAEIARRAPAIRVRFGPGQIPIWLIVRHSPARAMLSDPR
FSRTKTLEFRPPLTGAQIPDPNSLLWLDPPDHTRIRRLVSTGFAHRRIEQLRPWVAETARRHVTAMTAKD
APADLRAALAAALPVDVICQILGVPEIDRENVRTWSETLFRFATNREAAAAGQKALYGYMDSLVRERQAQ
LAAGEPVTKLFDVLITTQDTDDGRLNEVELRSLALTLLIGGFETTAGVITNAVTTLLTDRSQWESLVGNP
ALLPNAVEELLRYHPLSMTFPRVATEDVDLGEFTVRAGEVAIAPFAATNRDPDLYDDPDRLDLTREPVAN
LAFGHGAHHCIGAHLARVELTEVLSALIDIVPTLRLAVPVSELRYELAAPIGRPEKLPVAW
CYP1021A2 Frankia alni ACN14a
YP_714124.1
CAJ62566.1
70% to YP_001506746 EAN1pec
41% to CYP107D1 Streptomyces antibioticus
MSITEAVQNDQEIPSFPFDDTFSPHSSERLAEYAREAPAIRVRFGPGQLPIWLIVRYAPARAMLADSRFS
RTRTLDFSPPLTAGQMPDPNSMLWLDPPEHTRIRRMVNAGFAHRRIERMRPWIAATARARIDAMTAQGAP
GDIRTLAFHLPIEVICQLLGVPDLDREKVRTWSESLFRFHLDPKGAAEGLFALYGYMGELVRARKAAAGD
THSPEGLLDVLIAAADDDGTLTEPELHSLAMTLLIGGFETTGGVISNVITTLLTQRSHWESLVADPSGMP
NAIEELLRYHPLSMTFPRVATEDVDLGGFVVRAGEVVVVPLAAMSRDPAVFTDPDRLDLTREPVPNLTFG
AGVHHCIGAHLARVELTEVLTALIETVPGLRLAVAPAELRYELKAPIGRPETLPVVW
CYP1022A1 Frankia sp. EAN1pec
YP_001506696.1
ABW11790.1
33% to CYP107X2 Saccharopolyspora erythraea
MSTQAFEDFDPFDLAQAERHHAVMADMRERCPVARLSSGMIAVTRFADVRATLHEPALRNSHAARAPGVT
VPPEDRFFFFEYDPPEHHELRRLLLDLLSRRQSEQLAPSIRALVTELLTPLVGRGGAELVNEFSIPLASR
LMMRVAGFPEDDAPQWRQWIRDMVRSGFSFTNRNERGAGFEQCYPDVLAYLDGRLASAPATDSAQHGVLA
RVRDAQIDGEPLTRTQQRMILFSVVSAGTNTLANFMSNTLASLTREPGLFESLRDDRSLVPVVVEESLRR
DSPSMHLTRLCAEATTIADVPVAPGEKVLLSLASANRDATVFPDPDEFRTDRRDQPSHVAFGWGAHLCLG
APVARQAGVTMVDTFLGLVGAITLEPGTSPVPYLSPQGNGLDELRVCLAPTRAPARAET
CYP1023A1 Frankia sp. CcI3
YP_480874.1
ABD11145.1
40% to CAJ62848
31% to CYP220A1 Burkholderia fungorum
MATLPDLGDADALRDWHTSFRAIREHQRMYWDDAVGAWLVTRHADVEMGLYDHRLSSQGPTSFMAQLSAE
DLAKFADLQRFYESWMVFSNEPYHTVVRGSVQRVLTPRAVQKRQEAVRAAARSLLDRARAEVVDVNSDFA
RPLATAVISEVLGVPEQEWDNCSRWSHHIIDFISAPQPDASRAMAAAESYDQMCDYVYHLVEEHRRTGRD
DSPMLAVADVGAHAVVGTFAQFMTGGCDPISAAIANAVATLLAHPDQMQRLERDRSLIPTAIEEFIRYES
PFTLVPRVVTEPMTVAGQHLHEGSRVLFMLLAANRDPGVFERPDEVDVGRSPNPHLGFGKGSHYCIGAGL
ARLEMTESIEAIIDMAPNLELAGQVEWSSSLGLRSAVKLPVSVSR
CYP1024A1 Frankia alni ACN14a
YP_713272.1
CAJ61705.1
40% to CYP125F1 Mycobacterium avium subsp. paratuberculosis
MTIVETESIDLYSLASFEHGHPHALYARLREHDPVHWNDEPNGPGFWAVTRWEDIRAVNRDDENFSHWPV
SMIEDFMETEDKSMVNLDPPLHTVIRRAVVPGFMPSAVRRRMTRFVDAAEAIVDEIRPAGGCDLAVDVAG
KIAAYVTADVLRIPREDAVRLYEYIEIGLGGGAYTEQERQGATEALIRYSIQVWEDRRAHPGDDVCSMLA
ACEVDGAPMSLENFSANMTLLIVGAGDTTRHLIGGGLHALFTHPDQRELLQADLDGRMPAAVEEMLRWVT
PVVYNRRTALRDVEIGGRSISAGDKVCVYYGAGNRDPREFADPERFDITRSPNRHLAFSGLGQHFCLGAH
VARAEAIAMITTLLRAFPGIHPAGEMEWTRSNFVMGPAHLPVTW
CYP1025A1 Frankia sp. EAN1pec
YP_001511098.1
ABW16192.1
37% to CYP254A2 Rhodococcus sp. RHA1
MNQMPTPAAAAAPMPDEWCLKDFDHLSTDLAAVFPETMDRMRTLCPVTHTGQHGGFWVVTKYGDVLDVAQ
DWESFSSAYGLAIPPSTTHVRNIPVEVDPPEQRVYKKLVNSHFTPKAIAGWEAPARALVTDLIDEFIERG
ECEFMDDFARPFPSLSFFKFALDAPTEDLDKVSFLASKASIPNDPIGKECWAGLSEWINGFVEQRRQRPP
RGDVVDALLKAEFEGRPLTQKEIVGIVQLLILGGLETTAGALGLMLLRFSRQPEIPAYLRAHPERIPAGV
EELLRLDGPFIAIARTATRDIELDGKQISKGDRVLIYWASANHDDAEFTNPKTFDIDRSPNRHLAFGAGP
HRCLGSNVARLNMRIALEELLRRMDDIRLREDADIHFHSTLTRAPLHVPITFTPGPRSAPVG
CYP1025A2 Frankia sp. EAN1pec
YP_001509704.1
ABW14798.1
36% to CYP292A1 Mycobacterium vanbaalenii
MSYDSTAASGERAGPAGESIDDDWCRNQFDHLSQELVDNLYPALTRMRSLCPVTHSNQYGGYWVVTKYDD
VLRVAQEWETFSSAFGLTVPPSPIATRNLPVEIDPPLQREFKRLINAYFTPKAVRPWEPRTRALVNRLID
GFVERGECDFMAEFARPYPALSFFDVAIGAPADQIERVAYLASKSGAPKDPDAAACWRGLSEWINGFLEQ
RRCEPPRGDVVDAILSAEIQGRPITHEEIIGTVQLLILGGLETTAGALGQIMLRFCRQPEIPAALRENPD
LLPQAVEELLRLDGPFVQITRTAMHDTEIDGHQIKQGEKVIIYWASANRDEGEFPASDEFDLDRKINRHV
AFGVGPHRCVGSNLARMNLRIALDELLRRLHDLRLRDGAEIHFHPTVNRAPVAVPVTFTPGPRVGADG
CYP1025A3 Frankia sp. EAN1pec
YP_001508195.1
ABW13289.1
37% to CYP254A3 Rhodococcus sp. RHA1
MTDAATGQLDAEWVEHHFDHLSPELARDLHPTLALARSRCPVAHSDQYDGFWVVTGYEDVLRVAQDWETF
SSELGITVPHTPTPMKILPVTIDPPLQRTFKRLINTHFRPVVVVEWEQQTRALVNRLIDGFIEAGECDFM
TEFARPLPGLAFFDMALHAPAEDLEMVNHWATLASLSHLEESRESHGKLAAWIGALMAKRREEGPRGDVV
DAVMNADIEGRPITPAEAVGTVQLLVLGGLETTAGALGMSMIRFCRHPEILARLRENPELIPDAVEELLR
LDGSFICIARTARHDTELGGRQIKAGERVLIYWASANRDESEFDNADTFDLDRGRNRHIAFGAGPHRCAG
SNLARMNLRIALEEIVTRLVDVRLQPGADIDYHSTFNRAPQSVPITFTPGPRLTPAG
CYP1025B1P Frankia alni ACN14a
CAJ58987
CT573213.2, no YP#
42% to CYP188A5 Mycobacterium vanbaalenii
VLSDLTEAEIDGERLSDEELSGIVMPLLLGGMDTTAGRTGNAFLRIDADP
ALRRRLLEDPAVLEIATEEFLRRDTPVQGLTRVVTRDAQFHGRQLKKGDR
VMLMFAAANRDPSTFACPHDIDLDCGTNRHLAFAPVVHRCLGSNFARAMF
RVMITALLRRLPDGHVAPPVERLADAGDVYTVKHLPVRLTPGPREGVGPP
ACASRTA*
CYP1026A1 Frankia sp. EAN1pec
YP_001508774.1
ABW13868.1
38% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
MSVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPLVPGASLWYLL
DYESVYTALRDWETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLNAHFSPGAIRALEPDIRRTAV
ELIESFKDSGQCDFVTDFALHFPTRVFERMFGVPLEDHDQLTAWVHTFGQQMATQTAIDKAVAAEQEVLA
YLGKKLDEREQSPREDLLGAIAFMEVDGARISRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQ
AILADPKLIPSTVEELLRSYDILSHTMIVAKDVEFNGCPMKKGDRVVTMISAANRDPNEFPDPDTFDVSR
KPNRHMAFGVGPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQSMKWAVTSMESLPLEWDVEAV
N
CYP1027A1 Frankia alni ACN14a
YP_713106.1
CAJ61538.1
37% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
MTTPTTEITDHRIVGVGTVGDAGDRFDALRSLHRIVRVTEPDRSYWMVLDHDLARECLQNPAVFSSEVIT
PLSPDPPLSMIPIQLDPPEHTQWRRLLAQYFSPRTMGLLRPRLEERTTELVAAIRARGECDYVEDFALEL
PTVVFLELMGLPIDELPTFLEWEKQALAPTDSGDFDKDRQIGGIFSVVGYFQAEIARRRDSGERGDGLLG
AMLDWELDGAPAPDDALVNCSLLLFLAGLDTVAMSLSFAMHHLATHDADRRHVAGLAAAGEPLDGVVEEL
LRFYAVPEVGRKVKQDIEIGGQQLRAGDLVLFPLVAANRDEALVAGAGTVDLVSRPPAPHLAFGAGPHRC
LGSHLARIEMNVALAGWHRVIPAYALGEGTAPQAYWGNVHGIFSLPLAEFGS
CYP1027B1 Frankia alni ACN14a
YP_714309.1
CAJ62755.1
48% to CYP1037C1 YP_001508864 EAN1pec
36% to CYP215A1 Thermobifida fusca
MDYVTGPPPAPALSLFQRMDDHQAAGRPAVRTGEAGGYWIFTDHDVILEGLQQPDLWSSSVIVPTESDPP
YRWIPIMLDPPEHTKWRHLLGSYFSPGRTKAMKAGQHRLAVELIEGLRDQGECDFVRDFAQVFPSTIFLE
IMGMPREQLGEFLRWEHMILHQNNDSDPDGSVRLAGMQAVQTYFAGLVAQRRANPDPHAQDVVSAAISWE
IDGEPVSDADVLNCLLLLFMAGLDTVAGQSSYALLHLATHPADRARIVAEPALIPHAVEELLRAYPIVQT
ARKATRDAQFHGCPIRKGDMAAFPLSAAGRDEQAYPDARRVDLDRPTTRHLSFGGGPHRCLGSHLARQEL
AVLLQEWHRLIPDYELAELPLEHGGGVWGLESLPLRWAV
CYP1027C1 Frankia sp. EAN1pec
YP_001508864.1
ABW13958.1
40% to CYP254A2 Rhodococcus sp. RHA1
MSVTEPVPSRCPAVTYSPHEQRPVGEWTAFFDQLRDEAPVVRNTFANGYYVLTRYEDILSAYQDTDTFST
QAVTVLEPDPSYRWIPHMLGGNEHRQWRRQLGPYFSPRAIEGLDDRIRARAVGLIESFADRGSCDVITDF
SFHFPTTIFLELMGLPVGDLDRFMAWEANILHSNGSTPEEIAHNRTTAMAAVYEYFGSVIADRRRRPGDD
LVSHAIAFKVDGRPVTDDEVLSYCFFMFMAGLDTVAAALGYSLYHLATHPEDRARIVADPALIPSAIEEI
LRAYAFTIPARKVTRDIEVAGCPIAAGSMVQLPIKAAMRDGAAFASASEVLIDRKPNNHIAFGAGPHRCL
GSHLARHELAIALEEWHKRIPDYRLADDAVITELGRSSGPDTVPVVWAR
CYP1028A1 Frankia sp. EAN1pec
YP_001508760.1
ABW13854.1
35% to CYP107AT1 Saccharopolyspora erythraea
MSTVGDRELNGAVGIVHTSIEAVNDGANPYQTLAPLHDYGEAVIMPEGYLAVWGHQACMDIMRSSAWGRH
LPDSSIRAAWQHDLTAEQAELLRQEEPPHIAPWLQTFDGPEHARQRSLVSKPFTPRRLQVMRQRTTEVVG
RLAAAAPRGVPFDFMSTIAFPIPNQVVGELVGLPLQDRDWFAERAVLLLAERDPRSSFDQLRRSTRAIRE
LGDYIRGLLRGETCPTEGLASDLLEAEETGARLTEPELLSLMLLMYVAGHGTTAHSMGNGLYVLLQHPDQ
LAALRADRGLTRSAVEEILRWDSGVTSVDYSAVEDTDIDGIRVPAGTPAHLFLSAANRDPRVYTDPGSFD
IRRTEGPTVVFGAGPHFCLGAALARLELEIALDVLLAGFASIELATSTPPRGDSFNYRYFTQLPIVVSDN
CYP1029A1 Frankia sp. CcI3
YP_480965.1
ABD11236.1
40% to CAJ62848
42% to CYP107AH1 Streptomyces peucetius
MDGQGSVRRYINVYRNDNDIRGLENLETRVEESDVVWIIPAVAGGSIRPAVQEPKVPEVLPSEFFLNPGP
SPHATNAELRSKCPVHQINYPPGSEAYAVLGHRAVAEAFTDSRLSKEAENLPPRFRDRALSSSLLMVRNL
GFADPPDHARLRRPISRAFLPNAIADLRPRIQDVVDDLIDTFPAPGEIDLLGAFALPLPLTVICEYLGIP
VQDRPLFLEWGYILSQDPFQHAESELKAATEEFTDYFTRLVARRRTDLRKDLLSELVRAADSDALSEREL
LSTILLLLIAGHKTVANLIGNGTALLLGHPGQLDLLRTTPELIPAAVEEMLRFEGSAAWASMRVAVEDMR
LAGTEIPRGSFVHLLLSSAGHDPEAYDEPERFDVTRSPNHHLAFGHGAHFCVGAPLGRLQGDIAFTTLLR
RLPGFELAVRQDEVEWLADSSLSRGLRALPIRVRERLPR
CYP1030A1 Frankia sp. EAN1pec
YP_001510577.1
ABW15671.1
38% to CYP147F1 Streptomyces peucetius
MPVQTMDFAAPSFRTDPFPAWSDLRRAGPLHRDVSGAWIVVSHREVGRLLADPRVGKDLRRLSTYGAQRP
YGPDGLAEYYIEQWMECRLPTMHRRWRQLVLPGFTHRAVHGLRAELCRTADDLLTHALTHAPSDGQVDLL
RDFARPFPVAVIVRVLGLTDLDTDRLAQLSRTIAAVLEPNAAVSAREAGDAALAELAGLLWDAVRADRGP
HPDGFLRRLVDANKGLLSPEQLIATVLLLFLSGNDTITGLIANGVLALASVPDQADRLRAHPELLPMAVE
EVLRFDAPACVAVRTTYEPMTIDGVTVERGAALLLAISSANRDPAAFAEPDVFRVDRRPIRHFAFGSGDH
TCVGIGLARMEATIALEALLHRFPRLTHDPSTLRWSDALYLRSPENLVLLCTVPPAPERACGVPEVGLGR
DLG
CYP1031A1 Frankia sp. EAN1pec
YP_001506244.1
ABW11338.1
41% to CYP107AN1 Bradyrhizobium japonicum
MTDTRTPRAASGPYVFNPFADGFAEDPYPHYAQLRENAPAHRHPLGFWLVSRYEDVARIQRSGHSVDERH
ITELPEWKSESRTLGKQNRLMHGLSMLDQDPPNHTRLRRLVTKAFTRRAVDALEGRIERIVDDALDRMAE
AGRVDLVAELAFPLPFTVISELLGIPVLEHGRLRELTGTMVRALEPLPDPGLQAEIRAANDEVAAIMRAV
TDWKRDNPGDDLLTALIGAEHDGDVLSAEELVAQVMLLYVAGHETTVNLVAGGILTLLRHPDQMRRLRDE
PELAGNAVEELLRYDSPVHLMRRITLEPLSVRGTEIPPGVFVTVCLAAANRDPDFWGPDADEVRLDRTDA
HRHVSFGAGIHHCVGAALARLEARVAISRFVGRFPAPALEDVRWNGRINVRGPASLTVAVR
CYP1031A2 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7216
57% to CYP1031A1 Frankia sp. EAN1pec
CYP1032A1 Frankia sp. EAN1pec
YP_001508733.1
ABW13827.1
43% to CYP107AZ1 Roseiflexus sp. RS-1
MRFDPTAAAIKADPYPAYARLRAEAPVEWNDLGFWTVARHQDCLFALRDKRLGKEHPFAWAIENPDLPLI
QIHDAMMIFHDGQAHRRVRRLFTSAFTTRAADRLRPDIAAIVDELLAELVERDEFDLVSQFCYPVTLRTI
CYMLGVPRSDIDWCHSLTKNVQRLLEQDLSRAELVQISDSTVTLSEYFAEHVRDRRRNPKDDLISLLVQA
EIDGERLTEEEIIANSILLYLGGEDTNANLMANSTLALLAAPDQAELLRHDAGVVHATAFDELLRYDSSF
QMLTRYANEPVEIGGQRIEEGQTVMCLLGSANRDEREYERPDELDLRRVVKRGVSFGGGPHLCVGAPLAR
AQLQEALPRLFRAFPWMQNLTEELEYPLLVVRGPKELTLATGKQRVMA
CYP1033A1 Frankia sp. EAN1pec
YP_001508979.1
ABW14073.1
35% to CYP187A5 Mycobacterium ulcerans
MLKPVQPADRIVGDVDDDVDYVDGQITDFHARLAALRAEKGVARLRFGPDTGLMLLRHADVVVALRDETR
FSKSGAFRPITFPFLGPNITGYDGHEHNVKRALVSPTFRRTMIPRYIQPVIRPIAEELVADLATLGEADL
MATFAKKYPMRITSRLLGIPSDEEDKLASWAFSMLHIAGDPDGAMKANAEFTEYVGPLIDTRRAHPRDDL
LSALLTEEVEGQHLDHDEVLGFLRLLFPAGVDTTWQALGSLVHAVLEHPEVHQRLRRDEEERAWAVEETL
RWESPVAADSRLTLQDVVVSGVEIAAGELVRLGLSVANRDPDVFPDPDRWNLDRRPTNHITFGLGRHFCL
GAHLARVELQVALDVLLQRLPNLRLLEQPQITGIGIRGPKTLRVAWDAPSTPGAP
CYP1034A1 Frankia sp. EAN1pec
YP_001504987.1
ABW10081.1
37% to CYP187A1 Mycobacterium smegmatis
MSTTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDGPAMFSGLPYP
DRPHFSAFSYAACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQHRRYRGLVQPSFVPGKAKWW
ISNWIEETVDLLIDGFVDAGRAELNVDFCAAIPVLTITSSFGVPVDRALDIRAALTRPDEIVRMLEPIVA
ARRADPQDDLISILVQAEMTDENGVTHRLTDAEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAV
RADRSLLRLAIEESLRWSPTDPMFSRWVTEDVDFFGVHMPAGSVLHLCIGAANRDPARWDRPDEYDITRA
LRPSFAFGGGAHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFIGMYERGATEIPVVFG
CYP1034A2 Frankia sp. EAN1pec
YP_001509649.1
ABW14743.1
35% to CYP187A2 Mycobacterium avium subsp. Paratuberculosis
MTRPDSIVLLDRARLREVFDLRNEANLGTVAGYEEDPYPRWHELRELAAVHPGTLHELTGFSGPVLFQGL
PFEDRPHFTAFTFAACDEALKNQEVFASSPVAVDLEGGRLAPLNSIFSMAGAQHRRYRRLVQSSFVPPRM
AWWTEKWIETTVHALIDWFAGDGSADLNVDFSAAVPVLTITGSFGVAVEQAIAIREALSSPERLVPLLAP
IIAARRETREDDLISVLVDAEVQDDDGNPHRLSDAEIYSFAVLLLMAGSGTTWRQMGIVLTALLQRPEIL
DAVRRDRQLLRNAIDESLRWMPTNPMFSRFLTKDVEFHGAHLPKGAVLHLALGAGSRDPRRWERPDEFDV
TRPPKPSLGFGGGPHVCLGMHVARAEMYTGIGALLDRLPNLRLDPDANPPRIIGMYHRGPTAIPVLFG
CYP1035A1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_8399
34% to CYP107BH1 Frankia alni ACN14a
CYP1035A2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY3625 74% to CYP1035A1
CYP1036A1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_10544
43% to CYP145C1 Streptomyces scabies SCAB90701
42% to CYP217A1 Thermobifida fusca
CYP1037A1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_3522
38% to CYP163B1 Salinispora tropica (marine actinomycete)
CYP1038A1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7163
33% to CYP208A1 Streptomyces globisporus
CYP1038A2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2020 81% to CYP1038A1
CYP1039A1 Streptomyces bingchenggensis
No accession number
Wensheng Xiang (Ann)
Submitted to nomenclature committee Jan. 30, 2010
Clone name SBI_7500
42% to CYP107AV1 Saccharopolyspora erythraea NRRL23338
CYP1040A1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE1257 32% to CYP107T1
CYP1041A1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE4151 31% to CYP183B1
CYP1042A1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE4609 32% to CYP135B4
CYP1042A2 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY972 75% to CYP1042A1
CYP1043A1 Streptomyces SN-593
No accession number
Shunji Takahashi
Submitted to nomenclature committee Jan. 28 ,2011
SRE9042 29% to CYP174B1
CYP1044A1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY2316 39% to CYP107L2
CYP1045A1 Streptomyces RK95-74
No accession number
Shunji Takahashi
Submitted to nomenclature committee Feb. 3 ,2011
SCY910 81% to CYP1045A2
CYP1045A2 Streptomyces sp. MP39-85
GenPept ACO94495.1
ML-449 biosynthetic cluster
CYP1045A3 Streptomyces sp. DSM 21069
FJ872523.1
BE-14106 biosynthetic cluster
BecO
CYP1046A1 Streptomyces griseus
AP009493.1 444916-446232 (+) strand
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR410
84% to CYP208A1
CYP1046A2 Streptomyces anulatus
HM038106.1
Actinomycin biosynthetic gene cluster
89% to CYP1046A1
CYP1046A3 Streptomyces flavogriseus
CP002475.1 49894-51195 (-) strand
84% to CYP1046A1
CYP1047A1 Streptomyces griseus
No accession number
Takuya Makino
Submitted to nomenclature committee May 23 ,2011
SGR1079
37% to CYP197C1
CYP1048A1 Streptomyces scabiei 87.22
FN554889.1 361391-3615100 (+) strand
Only 33% to CYP107P4 Streptomyces bingchenggensis
CYP1048A2 Streptomyces turgidiscabies
AY707081.1 13770-14990 (-) strand
Pathogenicity island
87% to CYP1048A1
33% to CYP107BT1 Streptomyces SN-593
CYP1049A1 Burkholderia sp. CCGE1002
YP_003609334.1
CYP1049A2 Burkholderia phymatum STM815 plasmid pBPHY01
GenPept ACC75152.1
CYP1049A3 Enterobacteriaceae bacterium strain FGI 57
GenPept AGB77447.1
CYP1050A1 Rhodococcus erythropolis
AB694012
rauA gene from rau gene cluster for aurachin RE biosynthesis
36% to CYP164A3 Mycobacterium marinum
33% to CYP164A1 Mycobacterium leprae
32% to CYP164A2 Mycobacterium smegmatis
CYP1050B1 Streptomyces sulphureus L180
AJTQ01000106
46% to CYP1050A1 Rhodococcus erythropolis
42% to CYP107BD2 Frankia sp. Ccl3
40% to CYP107P4 Streptomyces bingchenggensis
less to other CYP107 sequences
Unidentified fragments
Rhodobacter capsulatus 1st sequence from a genome project
Rhodobacter capsulatus 2nd sequence from a genome project
Rhodobacter capsulatus 3rd sequence from a genome project 32% id with U08223