P450s that have appeared since the 1993 P450 nomenclature update.
      This is part E of the bibiographic P450 files.  
      This section contains bacterial sequences CYP101 to CYP174.  
      This includes references that were incomplete and duplications
      of sequences that were already in the update.  If a sequence 
      is assigned an accession number that was not in the old update
      it is included in this list.  48 new P450s were added July 27, 2000
      Four new sequences were added Jan. 9, 2001 CYP102C1, CYP172-174.
      Added CYP175A1 9/17/2001
      Compiled by David R. Nelson
      Last modified June 2, 2003 added 25 new sequences. 
      Last modified Nov. 5, 2003 There are now 501 bacterial P450s
      Last modified Dec. 2, 2003 added 4 seqs in CYP153 family
      Last modified Feb. 23, 2005 added 26 seqs from Rhodococcus sp. RHA1 
      Last modified Feb. 23, 2005 added 155C1 and 155C2
      Last modified Sept. 20, 2005 added 18 Sorangium cellulosum seqs.
      Last modified Nov. 17, 2006 
      Last modified Dec. 31, 2007 
      Last modified Aug. 19, 2009
      Last modified Sept. 4, 2009 added four archaeal P450s
      Last modified June 22, 2010

51 Family

101 Family

102 Family

103 Family

104 Family

105A Subfamily

105B Subfamily

105C Subfamily

105D Subfamily

105E Subfamily

106 Family

107A Subfamily

107B Subfamily

107C Subfamily

107D Subfamily

107E Subfamily

107F Subfamily

107G Subfamily

107H Subfamily

107J Subfamily

108 Family

109 Family

110 Family

111 Family

112 Family

113A Subfamily

113B Subfamily

114 Family

115 Family

116 Family

117 Family

118 Family

119 Family

120 Family

121 Family

122 Family

123 Family

124 Family

125 Family

126 Family

127 Family

128 Family

129 Family

130 Family

131 Family

132 Family

133 Family


51 Family

A note on nomenclature.  CYP51s were originally all called CYP51, because only one 
gene was found per species and they all seemed to be in this one conserved family.
However, rice had many CYP51s in at least two sequence groups, so subfamilies
have been designated for CYP51s.  These are not the typical subfamilies, but only 
one subfamily is created for each major taxonomic group.  CYP51A for animals,
CYP51B for bacteria. CYP51C for Chromista, CYP51D for Dictyostelium, CYP51E
for Euglenozoa, CYP51F for fungi.  Those groups with only one CYP51 per species 
are all called by one name: CYP51A1 is for all animal CYP51s since they are 
orthologous.  The same is true for CYP51B, C, D, E and F.  CYP51G (green plants) 
and CYP51Hs (monocots only so far) have individual sequence numbers.

CYP51B1    Mycobacterium tuberculosis (Actinobacteria)
           GenEMBL Z80226 (34809bp) gi 1550642 Rv0764c
           complement (6140-7495)
           33.7% identical to CYP51 over 439AA overlap
           this is a bacterial CYP51

CYP51B1    Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4932
           82% to 51B1 M. tuberculosis

CYP51B1    Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to CYP51B1 Mycobacterium marinum = ortholog

CYP51B1    Mycobacterium bovis subsp. bovis AF2122/97 (Actinobacteria)
           NC_002945 complete genome complement(858662..858868)
           CYP51 100% match
           locus_tag = Mb0786c

CYP51B1    Mycobacterium avium (Actinobacteria)
           TIGR contig:3273:m_avium Length = 5,475,738
           79% to CYP51 M. tuberculosis
3021360 TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 3021539
3021540 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 3021719
3021720 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 3021899
3021900 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 3022079
3022080 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 3022259
3022260 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 3022439
3022440 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 3022619
3022620 PADSYRNDHSKMVVQLARPAKVRYRKR 3022700

CYP51B1    Mycobacterium smegmatis (Actinobacteria)
           TIGR contig:3439:m_smegmatis Length = 6,989,783
           80% to CYP51 M. tuberculosis
4858809 VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS 4858988
4858989 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV 4859168
4859169 ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 4859348
4859349 LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 4859528
4859529 VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 4859708
4859709 NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 4859888
4859889 DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 4860068
4860069 YRNDHSKMVVQLARPAKVRYRRR 4860137

CYP51B1    Methylococcus capsulatus (Proteobacteria)
           TIGR contig:221:m_capsulatus
           49% to CYP51 M. tuberculosis
           NOTE FUSION PROTEIN EXTENDS C-TERMINAL. 
           SEE J. Biol. Chem., Vol. 277, Issue 49, 46959-46965, December 6, 2002
           A Novel Sterol 14-Demethylase/Ferredoxin Fusion Protein (MCCYP51FX) 
           From Methylococcus capsulatus Represents a New Class of the Cytochrome 
           P450 Superfamily 
           Colin J. Jackson, David C. Lamb, Timothy H. Marczylo, Andrew G. S.
           Warrilow, Nigel J. Manning, David J. Lowe, Diane E. Kelly, and Steven 
           L. Kelly
908332 MSHPPSNTP
908305 PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 908126
908125 DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 907946
907945 LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 907766
907765 NLPLPVFKRRDQARVRLQELVTQIMERRARSQERSTNVFQMLIDASYDDGSKLTPH 907598
907597 EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 907418
907417 PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 907238
907237 FDPDRYTPERAEDKDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE 907061
907060 SYRDDYRKMVVEPASPCLIRYRRRDAP 906980

CYP51B1     Rhodococcus sp. RHA1 (Actinobacteria)
            No accession number
            Marianna A. Patrauchan
            Rha05830
            Submitted to nomenclature committee 12/13/04
            77% to CYP51B1 M. avium or M. tuberculosis

CYP51B1     Rhodococcus sp. R04
            AFAQ01001981 14835-16172 (+) strand
            Riu Xue
            Submitted to nomenclature committee Dec. 26, 2011
            85% to CYP51B1 Rhodococcus sp. RHA1

CYP51B1     Nocardia farcinica IFM 10152 (Actinobacteria)
            GenEMBL AP006618.1
            CDS complement(2757924..2759282)
MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFE
LAGKQVILLSGAEANEFFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHN
SALRAEQMRGHATTIAAEVDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNE
LDDRFARLYHELERGTDALAYVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPA
DKSDRDLLDVLVSVPNEDGGPRFSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHP
ELRDRVVAELDELFADGKDVSFHALRQIPLLEATLKETLRMHPPLIILMRVAQGDFEV
CGHHIAAGDHVAATPAISNRLPEDFPDPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRH
RCVGAAFALMQLKAIFSILLRDWEFEMAQPSESYRNDHSKMVVQLQQPCRVRYRRRVR
TS

CYP51B1   Mycobacterium vanbaalenii 
          ZP_01207535.1, AAT40578.1, EAS23094.1 
          Q5IZM4CP51_MYCVN Cytochrome P450 51 (CYPLI) (P450-LIA1) (Sterol 14-alpha 
          80% TO CYP51 Mycobacterium tuberculosis
MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSE LNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEF FAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVM HGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFY AKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASP AISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM AQPPESYQNDHSKMVVQLARPAKVRYRRRVRD

101 Family


CYP101A1    Pseudomonas putida
            GenEMBL D00528 (1950bp)
            Koga,H., Yamaguchi,E., Matsunaga,K., Aramaki,H. and Horiuchi,T.
            Cloning and nucleotide sequences of NADH-putidaredoxin reductase
            gene(camA) and putidaredoxin gene(camB) involved in cytochrome
            P-450cam hydroxylase of Pseudomonas putida
            J. Biochem. 106, 831-836 (1989)
            Note: only the last 93 nucleotides of the cam gene was cloned along 
            with two downstream genes.

CYP101A1    Pseudomonas putida
            PIR C60886 (last 8 amino acids)
            Romeo, C., Moriwaki, N., Yasunobu, K.T., Gunsalus, I.C.,
            Koga, H.
            Identification of the coding region for the putidaredoxin
            reductase gene from the plasmid of Pseudomonas putida.
            J. Protein Chem. 6, 253-261 (1987)

CYP101B1    Novosphingobium aromaticivorans
            NZ_AAAV01000165.1 
            complement(29626..30870) gene = Saro2804
            43% to CYP101
MLPHDRGQNSTRRITAMEAPAHVPADRVVDIDIYMPPGLAEHGF
HKAWSDLSAGNPAVVWTPRNEGHWIALGGEALQEVQSDPERFSSRIIVLPKSVGEMHG
LIPTTIDPPEHRPYRQLLNAHLNPGAIRGLSESIRQTAVDLIEGFAAQGHCNFTAQYA
EQFPIRVFMALVGIEASEAPRIRHWAECMTRPGMDMTFDEAKAVFFDYVGPLVDARRE
TPGEDMISAMINADLGDGRRLTRDEALSVVTQVLIAGLDTVVNVLGFIMRELAGNPAL
RADLRQRGADILPVVHELFRRFGLVSIAREVRRDIEFHGVHLKAGDMIAIPTQVHGLD
PRVNPDPLAIDPSRKRARHSTFGSGPHMCPGQELARKEVAITLEEWLRRIPDFALGPN
SDLSPVPGIVGALRRVELVWNT

CYP101C1   Novosphingobium aromaticivorans
           NZ_AAAV01000133.1 
           complement(4199..5389) gene = Saro1574
           44% to CYP101A1
MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTA
NGGHWIAARGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVM
KGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR
PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRP
WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLIPAAADELMR
RYPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIR
HTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPL
VWRA

CYP101D1   Novosphingobium aromaticivorans
           NZ_AAAV01000085.1 
           complement(6803..8068) gene = Saro0669
           44% to CYP101
MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAW
KRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVP
TKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVF
PVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAA
RRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP
ETVAEMRREPLKLQRGVEELFRRFAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHG
LDDRHHDDPMTVDLSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLK
DRAVPIYHSGIVAAVENIPLEWEPQRVSA

CYP101D2   Novosphingobium aromaticivorans
           NZ_AAAV01000042
           complement(5601..6899) gene = Saro0208
           63% to 101D1
MGTTRMDTFNPQESRLATNFDEAVRAKVERPANVPEDRVYEIDM
YALNGIEDGYHEAWKKVQHPGIPDLIWTPFTGGHWIATNGDTVKEVYSDPTRFSSEVI
FLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA
RGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAG
NNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVV
NFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFPVVSEARMVAKDQEYKGVFL
KRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGGPHRCAGMHLARMEVIVT
LEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR

CYP101D3   Sphingomonas sp. SKA58
           ZP_01304513
           78% to CYP101D2
  1 MPEHVPETMS RARAPRPEHI PEQYVHEIDM YALEGIEQGY HEAWKNIPKP DMPDLIWTPF
 61 TGGHWIATNG DTVREVYSDP TRFSSEVIFL PKEAGEKYEM VPTRMDPPEH TPYRKALDKG
121 LSLAQIRKVE SKVRKVAVDL IDSFVSRGEC DFSAEYANVF PVRVFMALAD LPESDVPTLS
181 RFAKMMTRPE GNTPEEMAKH LEEGNKGFFA YVEPIIQARR GKEGEDLITV MVNAEINGER
241 ITHDKALGLI SLLLLGGLDT VVNFLSFMMI HLAKNPQVVE ELRADPLKLM RSAEEMFRRF
301 PVVSEARMVA KDQDFRGIEL KRGDMILLPT ALHGLDDQLN DDPWRINLER RGISHSTFGG
361 GPHRCAGLHL ARMEVIVTIE EWLKRIPTFA MKPGAQPIYH SGIVAAVDNV PLIWSER

102 Family

CYP102A1   Bacillus megaterium
           Ruettinger,R.T.,Wen, L.-P. and Fulco, A.J. 
           Coding Nucleotide, 5'-Regulatory, and Deduced Amino Acid Sequences of 
           P450BM-3, a Single Peptide Cytochrome P450:NADPH-P450 Reductase from 
           Bacillus megaterium. 
           J. Biol. Chem. 264, 10987-10995 (1989)

CYP102A1    Bacillus megaterium
            GenEMBL J04832 (4957bp)
            Ravichandran,K.G., Boddupalli, S.S., Hasemann,C.A.,
            Peterson,J.A. and Deisenhofer,J. 
            Crystal structure of hemoprotein domain of P450BM-3, a prototype
            for microsomal P450s.
            Science 261, 731-736 (1993)
            P450 is N-terminal

CYP102A2    Bacillus subtilis
            GenEMBL D87979
            Yamamoto, H., S. Uchiyama, F. A. Nugroho, and J. Sekiguchi.
            A 23.4 kb segment at the 69 degrees-70 degrees region of the 
            Bacillus subtilis genome. 
            Microbiology. 143, 1317-20 (1997)
            Gene name yfnJ    66.4% identical to CYP102A1 P450 part only
            also called YetO (fusion of P450 and reductase like CYP102A1, P450 part is 
            N-terminal)

CYP102A3    Bacillus subtilis
            GenEMBL U93874, Z99117
            Sorokin, A., A. Bolotin, B. Purnelle, H. Hilbert, J. Lauber, A. 
            Dusterhoft, and S. D. Ehrlich.  
            Sequence of the Bacillus subtilis genome region in the vicinity of 
            the lev operon reveals two new extracytoplasmic function RNA 
            polymerase sigma factors SigV and SigZ. 
            Microbiology. 143, 2939-43 (1997)
            Gene name yrhJ  most similar to CYP102A2
            (fusion of P450 and reductase like CYP102A1 P450 part is N-
            terminal)

CYP102A4    Bacillus anthracis str. Ames
            GenPept AAP27014                
            bifunctional P-450:NADPH-P450 reductase 1 
            79% to 102A2
   1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFRMQTLSD TIIVVSGHEL
  61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETQEPNWQ KAHNILMPTF SQRAMKDYHA
 121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
 181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
 241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
 301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
 361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
 421 MLLQHFEFID YEEYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKNHEIKQ
 481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVAAL NDRIGSLPKE
 541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKG DELKGVQYAV FGCGDHNWAS TYQRIPRYID
 601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQRMWSDAMK VFGLELNKNM EKERSTLSLQ
 661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI
 721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
 781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF EPFLELLPAL
 841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
 901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNVGEAHLYF GCRHPEKDYL
 961 YRTELENDER DGLISLHTAF SRLEGQAKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI

CYP102A5    Bacillus cereus ATCC 14579
            GenPept AAP10153 
            NADPH-cytochrome P450 reductase/P450 fusion
            79% to 102A2 Bacillus subtilis
  1 MEKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKIAEEYG PIFQIQTLSD TIIVVSGHEL
  61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
 121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
 181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG DQEENDLLSR
 241 MLNVPDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
 301 VLTDPTPTYQ QVMKLKYMRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
 361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
 421 MLLQHFELID YQNYQLDVKQ TLTLKPGDFK IRILPRKQTI SHPTVLAPTE DKLKNDEIKQ
 481 HVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
 541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID
 601 EQMAQKGATR FSKRGEADAS GDFEEQLEQW KQNMWSDAMK AFGLELNKNM EKERSTLSLQ
 661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSDRSTRHIE VSLPEGATYK EGDHLGVLPV
 721 NSEKNINRIL KRFGLNGKDQ VILSASGRSI NHIPLDSPVS LLALLSYSVE VQEAATRAQI
 781 REMVTFTACP PHKKELEALL EEGVYHEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL
 841 KPRYYSISSS PLVAHNRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
 901 QSNFELPKDP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNLGQAHLYF GCRHPEKDYL
 961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQDEGRYGKD VWAGI

CYP102A6    Bradyrhizobium japonicum USDA 110
            GenPept BAC48147                
            NC_004463 complete genome 3173438..3176674
            NADPH-cytochrome P450 reductase/P450 fusion
            54% to 102A2
   1 MSSKNRLDPI PQPPTKPVVG NMLSLDSAAP VQHLTRLAKE LGPIFWLDMM GSPIVVVSGH
  61 DLVDELSDEK RFDKTVRGAL RRVRAVGGDG LFTADTREPN WSKAHNILLQ PFGNRAMQSY
 121 HPSMVDIAEQ LVQKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
 181 SLVRSLETIM MTRGLPFEQI WMQKRRKTLA EDVAFMNKMV DEIIAERRKS AEGIDDKKDM
 241 LAAMMTGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYTLYALLKH PDILKKAYDE
 301 VDRVFGPDVN AKPTYQQVTQ LTYITQILKE ALRLWPPAPA YGISPLADET IGGGKYKLRK
 361 GTFITILVTA LHRDPSVWGP NPDAFDPENF SREAEAKRPI NAWKPFGNGQ RACIGRGFAM
 421 HEAALALGMI LQRFKLIDHQ RYQMHLKETL TMKPEGFKIK VRPRADRERG AYGGPVAAVS
 481 SAPRAPRQPT ARPGHNTPML VLYGSNLGTA EELATRMADL AEINGFAVHL GALDEYVGKL
 541 PQEGGVLIIC ASYNGAPPDN ATQFVKWLGS DLPKDAFANV RYAVFGCGNS DWAATYQSVP
 601 RFIDEQLSGH GARAVYPRGE GDARSDLDGQ FQKWFPAAAQ VATKEFGIDW NFTRTAEDDP
 661 LYAIEPVAVT AVNTIVAQGG AVAMKVLVND ELQNKSGSNP SERSTRHIEV QLPSNITYRV
 721 GDHLSVVPRN DPTLVDSVAR RFGFLPADQI RLQVAEGRRA QLPVGEAVSV GRLLSEFVEL
 781 QQVATRKQIQ IMAEHTRCPV TKPKLLAFVG EEAEPAERYR TEILAMRKSV YDLLLEYPAC
 841 ELPFHVYLEM LSLLAPRYYS ISSSPSVDPA RCSITVGVVE GPAASGRGVY KGICSNYLAN
 901 RRASDAIYAT VRETKAGFRL PDDSSVPIIM IGPGTGLAPF RGFLQERAAR KAKGASLGPA
 961 MLFFGCRHPD QDFLYADELK ALAASGVTEL FTAFSRADGP KTYVQHVLAA QKDKVWPLIE
1021 QGAIIYVCGD GGQMEPDVKA ALVAIRHEKS GSDTATAARW IEEMGATNRY VLDVWAGG

CYP102A7  Bacillus licheniformis ATCC 14580
          GenEMBL AAU24352
          Rey,M.W., Ramaiya,P., Nelson,B.A., Brody-Karpin,S.D.,
          Zaretsky,E.J., Tang,M., de Leon,A.L., Xiang,H., Gusti,V.,
          Clausen,I.G., Olsen,P.B., Rasmussen,M.D., Andersen,J.T.,
          Jorgensen,P.L., Larsen,T.S., Sorokin,A., Bolotin,A., Lapidus,A.,
          Galleron,N., Ehrlich,S.D. and Berka,R.M.
          Complete genome sequence of the industrial bacterium Bacillus
          licheniformis and comparisons with closely related Bacillus species
          Genome Biol. 5 (10), R77 (2004)
          74% to CYP102A3 for the P450 domain
   1 MNKLDGIPIP KTYGPLGNLP LLDKNRVSQS LWKIADEMGP IFQFKFADAI GVFVSSHELV
  61 KEVSEESRFD KNMGKGLLKV REFSGDGLFT SWTEEPNWRK AHNILLPSFS QKAMKGYHPM
 121 MQDIAVQLIQ KWSRLNQDES IDVPDDMTRL TLDTIGLCGF NYRFNSFYRE GQHPFIESMV
 181 RGLSEAMRQT KRFPLQDKLM IQTKRRFNSD VESMFSLVDR IIADRKQAES ESGNDLLSLM
 241 LHAKDPETGE KLDDENIRYQ IITFLIAGHE TTSGLLSFAI YLLLKHPDKL KKAYEEADRV
 301 LTDPVPSYKQ VQQLKYIRMI LNESIRLWPT APAFSLYAKE ETVIGGKYLI PKGQSVTVLI
 361 PKLHRDQSVW GEDAEAFRPE RFEQMDSIPA HAYKPFGNGQ RACIGMQFAL HEATLVLGMI
 421 LQYFDLEDHA NYQLKIKESL TLKPDGFTIR VRPRKKEAMT AMPGAQPEEN GRQEERPSAP
 481 AAENTHGTPL LVLYGSNLGT AEEIAKELAE EAREQGFHSR TAELDQYAGA IPAEGAVIIV
 541 TASYNGNPPD CAKEFVNWLE HDQTDDLRGV KYAVFGCGNR SWASTYQRIP RLIDSVLEKK
 601 GAQRLHKLGE GDAGDDFEGQ FESWKYDLWP LLRTEFSLAE PEPNQTETDR QALSVEFVNA
 661 PAASPLAKAY QVFTAKISAN RELQCEKSGR STRHIEISLP EGAAYQEGDH LGVLPQNSEV
 721 LIGRVFQRFG LNGNEQILIS GRNQASHLPL ERPVHVKDLF QHCVELQEPA TRAQIRELAA
 781 HTVCPPHQRE LEDLLKDDVY KDQVLNKRLT MLDLLEQYPA CELPFARFLA LLPPLKPRYY
 841 SISSSPQLNP RQTSITVSVV SGPALSGRGH YKGVASNYLA GLEPGDAISC FIREPQSGFR
 901 LPEDPETPVI MVGPGTGIAP YRGFLQARRI QRDAGVKLGE AHLYFGCRRP NEDFLYRDEL
 961 EQAEKDGIVH LHTAFSRLEG RPKTYVQDLL REDAALLIHL LNEGGRLYVC GDGSRMAPAV
1021 EQALCEAYRI VQGASREESQ SWLSALLEEG RYAKDVWDGG VSQHNVKADC IART

CYP102A8   Bacillus thuringiensis serovar konkukian str. 97-27
           AAT62301
           98% to CYP102A4, 96% to CYP102A5
  1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFQIQTLSD TIIVVSGHEL
 61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETDEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDDVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YEDYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKKHEIKK
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI
721 NNEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MKVGEAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI

CYP102A9   Bacillus weihenstephanensis KBAB4
           ZP_01184381
           96% to CYP102A5
  1 MDKKVSAIPQ PKTYGLLGNL PLIDKDKPTL SFIKIAEEYG PIFRIQTLSD TIIVVSGHEL
 61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSYYR ETPHPFITSM
181 SRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKI PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YQDYQLDVKQ TLTLKPGDFK IRILPRNQTI SHTTVLAPIE EKLKNDEIEQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKS DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNI EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYQ EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVS LFDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELELLL EEGVYHEQIL KKRMSMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGVAPFRGFL QARRVQKQKG INLGQAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHIAF SRLEGYPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQEEGRYGKD VWAGI

CYP102A10   Erythrobacter litoralis HTCC2594
            YP_456909
            60% to 102A6
  1 MDAPTALAPI PQPPGKPIVG NAFTVDSSRL IQSLMELAEE YGPIFQLEVM GTPLVFVSGA
 61 DMVAEICDES RFDKTVRGPL KRLRLIAGDG LFTGDTDDPN WAKAHHILLP SFSQKAMGSY
121 LPMMTDIASQ LMLKWERLNS DDVIDVPMDM VRLTLDTIGV CGFGYRFNSF YREDFHPFIE
181 ALNRTLDTTQ KMRGLPGEKL LKRQQIEQLN EDAAYMNNLV DEIIRERRQT GESGQGDLLD
241 FMLSGRDPVT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLQRAYAEVD
301 EVLGRNIDQT PTLSQIGRLP YIRAILSEAL RLWPTAPAMG LAPFEDEVLG GKYAIAKGTF
361 TTVLIPSLHR DKLVWGENPE AFNPDNFSPK AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLGMLLQR FELFDHADYQ LRIKETLSIK PDGFTIKARL RHDVERGGVA TVEPESKTPD
481 QAAAVPSHGT PLLVLYGSNL GSSEGFAREL AQRGEFSGFD VTMAPLDAHV AKLPTDGAVA
541 IACASYNGMP PDNAAKFVDW LEQADAADAP LSNVSYLVLG CGNSDWAATF QVVPRKIDAL
601 MEQHGAERLV PAEELDARGD LDTQFHDWLD GLIPQLGDAF DIDLESGFDA VFEPLYTVEI
661 TDSITGNTVA DRVGAREVEV VANRELKDTS KDEGRSTRHL EVRLPEGMEY EPGDHLCVVP
721 VNDPAVVDRL LKRFGLDRDT FVRIESRSDM RGPFPSGSTF SVLNLAETAG ELQAVATRKD
781 IATLARYSEC PNSRAALEAL AAPPSADGTD RYTSEVLEKR RSVLDMLEEF PACDVPLAVF
841 LELIPFLSPR YYSISSAPEA NQGLCSITVG VVKGPALAGT GEFKGTCSAY LADLPPGDRF
901 RAVVRKPTAQ FRLPDNPETP VIMIGPGTGV APFRAFLQRR DHLQEDGAVL GEAMLFFGCR
961 HPDIDYLYRE ELDDYDQRGV ATVHAAFSRH DGSRTYVQDL IAREADRVWE LIEQDARIYV
1021 CGDGARMEPD VRKALMAIYA EKKSSDEASA KAWIDDLVAQ DRYLLDVWVG

CYP102A11   Erythrobacter sp. NAP1
            ZP_01041731
            75% to CYP102A10
  1 MATNATLTPI PQPPGKPLIG NALTVDASQQ IQSLMELAEE YGPIFQLDMM GTPIVIISGA
 61 DLVAEVCDEK RFDKSVRGPL KRLRLIGGDG LFTGDTDAPN WSKAHNILLP SFSQKAMGSY
121 LPMMTDIATQ LVMKWERMNS DDVIDVPKDM IRLTLDTIGV CGFGYRFNSF YREDFHPFIR
181 ALTRTLETTQ KIRGIPGEKL LKGDAVKQLH RDAKYMNNLV DEIIRERQRS GGDGPEDLLD
241 FMLSGRDPLT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLTRAYAEVD
301 TVLGRNIDQP PSLKQIGQLP YIRAILFEAL RLWPTAPAFG LAPFEDEVLG GKYLIPKGTF
361 TTVLIPSLHR DKSVWGENPE VFDPENFTAE AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLAMILQR FELFDHSDYK LDIKETLSIK PDEFTIKARM RKDVERGGKA TEDAEEASTE
481 PAEPKVPKHD TPLLVLYGSN LGSSESFARE VAQKGEFSGF EVEMAPLDDY VGKLPEDGAV
541 AIACASYNGM PPDNAAKFID WIEGKDGAAP DLSGVSYMML GCGNSDWAAT FQAVPRLIDA
601 RMEELGAKRI VPTTELDARS DVDTQFHTWL DALMPQLGEH FDLDLSGEAA GIAEPLYKVE
661 VTQSVTANTV ASRVGAHAVK MVANRELKNT DIGEGRSTRH IEVELAQGET YQPGDHLCVV
721 PENDDAVVER LLRRFNLDAD TYVRIESRSE MRGPFPSGST FSVYNLAKTA GELQAVATRK
781 DIATLALYTE CPNSKPALEK LAQPPQEDGT DQYATDVLAK RKSVLDLLED YPACDLPLAV
841 FLEMIPFLSP RYYSISSAPG DTPQTCSITV GVVKGPALSG KGTFKGTCSN YLAELEPGAS
901 FNAVVREPTA NFRLPDDPKV PLIMVGPGTG LAPFRGFLQE RDALASSGEE LGPARLYFGC
961 RTPDEDFLYR DELEDYDKRG IVTLRTAFSR VDEGKCYVQD HIADDADAIW EMLEAGGRIY
1021 VCGDGARMEP DVRAALAKIH SDKTGSTPAE AQSWVGDLIT NERYSLDVWV G

CYP102A12   Rhodopseudomonas palustris HaA2
            YP_487251
            84% to CYP102A6
  1 MSSSNKLAPI PHPPKQPVVG NMLSIDTKAP VQHLVRLAEE LGPIFWLDMM GAPIVIVSGY
 61 DLVDEISDEK RFDKAVRGAL RRVRTVGGDG LFTADTSEPN WSKAHNILLT PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRDTLA EDVAFMNAMV DEIIAERRKA AAVADKMDML
241 GAMMTGVDKV TGEPLDDVNI RYQINTFLIA GHETTSGLLS CAIYALLKHP EVLQKAYDEV
301 DRVLGADTSV EPSYQQVNQL GYITQILKET LRLWPPAPAY GVAPIQDETI GGQYHLKRGT
361 FTTVLVLALH RDPSIWGPNP DAFDPENFSR EAESKRPANA WKPFGNGQRA CIGRGFAMHE
421 AALALGMILQ RFKLIDHTRY RMVLKETLTI KPEGFKIKVR PRSDKDRATR IASGVSHSVA
481 PAPAAPRARP GHNTPLLVLY GSNLGTAEEL AHRVADLADL NGFATRLGAL DQYVGQLPEE
541 GGVLIFAASY NGAPPDNATQ FVRWLSGDLP PDAFAKLRYA VFGCGNRDWT ATYQAIPRLI
601 DERLAAHGGR NIFVRGEGDA RDDLEGQFEA WFATLGPLAV KEFGIDAAFD RGADDTPLYG
661 IEPLAPAASQ PLAATGVAVA MRVLENRELQ DRAASGRSTR HIEIALPQGM SYRVGDHLSV
721 IPRNDPALVA AVAQRFGFAP DDQIRLSAAP GRRAQLPVGE AVSIGGLLGD HVELQQVATR
781 KQIVALAAHT RCPQTRPKLQ ALAGGDGAAD DAYRAEVLGK RRSVFDLLQE HPACELPFAA
841 YLEMLTPLQP RYYSISSSPA RDPARASVTV AVVEGPALSG RGIYRGACSS WLAGRGSGDT
901 VQATVRATKA CFRLPDDDRV PLIMIGPGTG VAPFRGFLQE RSARKVGGAT LGPALLFFGC
961 RHPAQDYLYA DELQGFAADG IVELHAAFSR GDGPKTYVQH LIAAQKDRVF ALIEQGAIVY
1021 VCGDGGRMEP DVKAALCAIH RERSGADATA AAAWIADLGA RDRYVLDVWA SV

CYP102A13   Rhodopseudomonas palustris HaA2
            YP_568957
            87% to CYP102A12
  1 MPSTNKLDPI PHPPKKPVVG NMLSLDTTAP VQHLVRLAKE LGPIFWLDMM GAPLVIVSGY
 61 DLVDEISDEK RFDKAVRGAL RRARAVGGDG LFTADTKEPN WSKAHNILLT PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRETLA DDVVFMNAMV DEIIAERRKA SESAADKKDM
241 LGAMLAGVDR ATGEPLDDVN IRYQINTFLI AGHETTSGLL SCAIYALLKH PDVLQKAYDE
301 VDRVLGSDTA VRPSYQQVNQ LSYITQILKE TLRMWPPAPA YGVAPIKDEV IGGKYHLKRG
361 TFVTVLVLAL HRDPAIWGPN PDAFDPENFS REAESKRPAN AWKPFGNGQR ACIGRGFAMH
421 EAALALGMIL QRFQLIDHQR YRMVLKETLT IKPEGFKIKV RPRSDKDRGD FVAAGASQVS
481 TPALAQAAPR ARPDHNTPLL VLYGSNLGTA EELATRVADL AELNGFSTRL GALDQYVGHL
541 PEEGGVLIFT ASYNGAPPDN ATQFVQWLSG DLPKDAFAKL RYAVFGCGNR DWTATYQAIP
601 RLVDERLAAH GGRNIFLRGE GDARDDLEGQ FESWFAKLGP LAVKEFGIDA KFARAVDDAP
661 LYRIEPVAPA AGNAVAAAGG AVPMKVLANR ELQDCAASGR STRHIEIALP EGISYRVGDH
721 LSVMPRNDPA LVAAVAQRLG FAPDDQIKLQ VAPGRRAQLP IGEAISVGRL LGDFVELQQV
781 ATRKQIAVMA EHTRCPQTRP KLQALAGGDG AADEAYRAGV LAKRKSVYDL MQEHPACELP
841 LHAYLEMLSP LAPRYYSISS SPLRDPSRAA ITVAVVDGPA LSGRGHYRGV CSTWLAGRSV
901 GDTIHATVRA TKAGFRLPDD DRVPLIMIGP GTGLAPFRGF LQERAARQQN GATLGPALLF
961 FGCRHPAQDY LYADELQGFA AEGVVELHTA FSRGEGPKTY VQHLIAAQKD RVFTLIEQGA
1021 IIYVCGDGGK MEPDVRAALM AIHRERSGAD AAAASTWIDD LGACNRYVLD VWASA

CYP102A14   uncultured soil bacterium
            ABD83817
            74% to 102A12
  1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE LGPIFWLDMM GAPIVIVSGY
 61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA TDVAFMNKMV DEIVAERRKS AEASDGKKDM
241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYAIYALLKH PDVLKKAYAE
301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE ALRLWPPAPA YGIAPLKDET IAGGKYSLKK
361 NTFISILVTA LHHDPAVWGP NPDLFDPENF SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL TIKPDGFKIK VRPRSGHDRT VHAEAATAAV
481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA EDLATRVADL AEVNGFATRL APLDDCAGQL
541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG ELPNDAFAKL RYAVFGCGNR DWAATYQSVP
601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ FESWFAALGA AAVKEFGLES RFSRSADDAP
661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR ELQNKSGPDA SERSTRHIEV QLPGGMTYRV
721 GDHLSVVPCN APALVDRVAR RFGFLPADQI RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL
781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG DDADSSERYR ADILSRRKSV YDLLEEFPAI
841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS RCSITVGVVS CPASSTGRGL YRGVCPYYLA
901 SRREGESVFA TVRETKAGFR LPDDPSVPII MIGPGTGLAP FRGFLQERAA RKAGGATLGP
961 AMLFFGCRHP EQDYLYADEL KAFADEGITE LFVAFSRSEG PKTYVQHLLA TQKARVWDLI
1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC TGADANGGAK WIADLGAQNR YVLDVWAGG

CYP102A15   Bacillus pumilus ATCC 7061
            ZP_03053227
            61% to CYP102A3, 68% for the P450 portion
   1 MQQTSIIPKP KTYGPFKNIP HIKKGELSQT FWRLADELGP IFQFEFSKAT SIFVSNHELF
  61 QEICDESRFD KYIGTSLNKV RAFAGDGLFT SWTEEPNWRK AHHILMPAFS QQAMKGYHEM
 121 MLDIATQLVQ KWQRTGRDEE IEVAEDMTKL TLDTIGLCGF DFRFNSFYKE NQHPFIESMV
 181 NGLSEAMDQA SRLPVADKLM IKRRKKFEEN VDFMKQLVDD IIQERKKQDK TGDDLLSLML
 241 HAKDPETGER LSDENIRYQI ITFLIAGHET TSGLLSFAIY FLLKNPEKLK KAVQEADDVL
 301 QGGLPTFKQV QKLNYTRMVL NESLRLWPTA PTFSLYAKED TVIGGKYSIE KNQSVSVLLP
 361 KLHRDQAVWG EDAEEFKPER FLHPEKIPQH AYKPFGNGQR ACIGMQFALH EATMVLAMVL
 421 HNLELIDHTS YELDLKESLT IKPNDFKIKV RPRKQQLFMV PPKEETKKST TTDESKVKSH
 481 GTPLLVLYGS NLGTAQQIAN ELAEEGKAKG FDVTTAPLDD YTRQLPDKGA VFIVTASYNG
 541 HPPDHAKKFV DWVTQEKEQD LTNVTFAVFG CGDRNWASTY QRIPRLIDEA LERKGAKRAA
 601 DLGEGDAGGD MDEDKEAFQK TVFKQLAKEF QLTFQEKGKE NPKLSVAYTN ELVERPVAKT
 661 YGAFSAVVLK NEELQSEKSE RQTRHIELQL PEGKKYKEGD HIGIVPKNSD ALVQRVINRF
 721 NLDPKQHIKL YSEKKANHLP LDQPIQMREL LASHVELQEP ATRTQLRELA AYTVCPPHRV
 781 ELEQMAGEAY QEAILKKRVT MLDLLDQYEA CELSFVHFLA LLPGLKPRYY SISSSPKVDE
 841 KRVSITVAVV KGKAWSGRGE YAGVASNYLC GLKEGEEVAC FLHEAQAGFQ LPPSSEVPMI
 901 MIGPGTGIAP FRGFVQAREV WQKEGKPLGE AHLYFGCRHP HEDDLYFEEM QLAAQKGVVH
 961 IHRAYSRHKE QKVYVQHLLK EDGGMLIKLL DQGAYLYVCG DGKVMAPDVE ATLIDLYQHE
1021 KQCSKEAAEN WLTTLANNNR YVKDVWS

CYP102A16   Bacillus sp. C3
            FR775424
            97% to CYP102A9 and 97% to CYP102A4

CYP102B1    Streptomyces coelicolor cosmid F43.
            GenEMBL AL136502 CDS 10570..12153 gene="SCF43.12"
            Highly similar to the N-terminal P450 domain of Bacillus
            megaterium 41.9% identity in 497 aa overlap. 
            45% to 102A1 over 433 amino acids
            cloned and expressed by David Lamb and Steve Kelly

CYP102B2   Streptomyces avermitilis
           GenEMBL AP005050
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV7426 
           78% to 102B1 from Streptomyces coelicolor

CYP102B3    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05872
            Submitted to nomenclature committee 12/13/04
            62% to CYP102B2 

CYP102B4    Streptomyces scabies
            SCAB9321  
            David Lamb
            Submitted to Nomenclature committee Nov. 10, 2006
            80% to CYP102B2 Streptomyces avermitilis

CYP102C1    Rhodococcus sp. X309 
            GenEMBL AF059700.1 complement(3619-4584) runs off end of sequence
            partial gene 48% to 102B1 

CYP102C2   Rhodococcus erythropolis PR4
           YP_345116
           88% to CYP102C1 
  1 MNGPRGSRTR PRRASLVNLA VLGVVLVHTV LMSADKCPYP KSATRAGEIT AVQPQVFESI
 61 PSPAWRLPLL GDLLTVDSEK PIQKEMALAS KLGPIFEWKI VNNRVTVVSG VDLVAEVNNE
121 ALWAKSVGLP ILKLRKVAED GLFTAFNSEP NWRKAHNILS EGFSRSALRN YHPSMLRALG
181 GLTDSWDRVA DAGETIDASS DANKLALDVI GLAGFGYDFA SFIGEEHPFV GAMSRVLAHV
241 NSTSNDIPFL RKLRGNGADL QNEKDIALLR TVVDNVIAER QSKPGEHQDD LLDLMLHSAD
301 AETGEKLDPV NIRNQVFTFL VAGNETTAGT LAFALYFLSR HPDVADTARA EVADVTAGET
361 PAFEDVARMR YLRRVVDETL RLWPSAPGYF RKVRTDTTLG GRYDMPKGSW VFVLLPQLHR
421 DPVWGEDPES FDPDRFKPEN VKKRPAHAYR PFGTGPRACI GRQFALHEAV LALAIILQRY
481 NFQSDPEYKL DIRETLSLKP VGFELSLQRR

CYP102C3    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            61% to CYP102C2 Rhodococcus erythropolis PR4

CYP102D1   Streptomyces avermitilis
           GenEMBL AP005023
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV575 47% to 102A3 
           40% to 102B1, 44% to 102C1 partial seq 

CYP102E1    Ralstonia metallidurans
            GenEMBL NZ_AAAI01000371 
            104500-107000 region
            51% to 102D1
MSTATPAAALEPIPRDPGWPIFGNLFQITPGEVGQHLLARSRHHDGIFELDFAGKRVPFVS
SVALASELCDATRFRKIIGPPLSYLRDMAGDGLFTAHSDEPNWGCAHRILMPAFSQRAM
KAYFDVMLRVANRLVDKWDRQGPDADIAVADDMTRLTLDTIALAGFGYDFASFASDELDP 
FVMAMVGALGEAMQKLTRLPIQDRFMGRAHRQAAEDIAYMRNLVDDVIRQRRVSPTSGMD 
LLNLMLEARDPETDRRLDDANIRNQVITFLIAGHETTSGLLTFALYELLRNPGVLAQAY 
AEVDTVLPGDALPVYADLARMPVLDRVLKETLRLWPTAPAFAVAPFDDVVLGGRYRLRKD 
RRISVVLTALHRDPKVWANPERFDIDRFLPENEAKLPAHAYMPFGQGERACIGRQFALTE 
AKLALALMLRNFAFQDPHDYQFRLKETLTIKPDQFVLRVRRRRPHERFV
TRQASQAVADAAQTDVRGHGQAMTVLCASSLGTARELAEQIHAGAIAAGFDAKLADLDDA
VGVLPTSGLVVVVAATYNGRAPDSARKFEAMLDADDASGYRANGMRLALLGCGNSQWATY
QAFPRRVFDFFITAGAVPLLPRGEADGNGDFDQAAERWLAQLWQALQADGAGTGGLGVDV
QVRSMAAIRAETLPAGTQAFTVLSNDELVGDPSGLWDFSIEAPRTSTRDIRLQLPPGITY
RTGDHIAVWPQNDAQLVSELCERLDLDPDAQATISAPHGMGRGLPIDQALPVRQLLTHFI
ELQDVVSRQTLRALAQATRCPFTKQSIEQLASDDAEHGYA

CYP102F1   Actinosynnema pretiosum subsp. auranticum
           AF453501 complement(6501..9518)
           maytansinoid antitumor agent ansamitocin biosynthetic gene cluster I
           49% to 102A3
           gene = asm30
MVATGTRIPGPKPLPLVGNLLDVLTSDLDTDVDFLDRCHREHGG
IVALTFAGQRQVFASSHELVARMCSDPSWGKAVHPALEQVRDFAGDGLFTARGDEPNW
GKAHRLLMPAFGPTAMRDHFPAMLDIAEQMLVRWRRFGPDHRIDVADDMTRLTLDTIA
LCAFGARFNSFYRDRAHPFVDAMVRSLVEAGERAERLPGVQPFLVGRNQRYRDDIATM
NRIADGIVAARAALPAGERPDDLLERMLTCADPVTGERLSARNVRYQLATFLIAGHET
TSGLLSFAVHRLLAHPEVLRKAKDAVDGVLGDRVPAFEDLARLDYLGQVLRETLRLHP
TAPAFALAPDEPAELGGHAIGAGEPVLVMLPTLHRDPAVWRDPDVFDPERFAPERMDE
IPACAWMPFGHGARACIGRPFALQEATLVLALVLQRFDLALADPDHRLTIKQTLTLKP
DSLVVRARPRADRPGATATVETVVPHQVPATHRHGTPLHVFYGSNGGSGEGLARTIAG
DGAARGWATSVAPLDDAVRALPASGPVVIVSSSYNGAPPDNAAHFVRWLTQDGPDLSG
VDYLVLGCGNLDWSATYQRVPTLIDEAMAAAGARRLRERGATDARADFFGDWERWYEP
LWPLLSAECGVEVGEIGPRFRVVESDAADGLGDLASAVVLENRELVRGPDAGSKRHLE
LRLPDGTSYRTGDYLSVLPQNHPDLVRRAVARLGTRAERVVTVESSAPTGLVPVGRAL
RVDELLTRCVDLSAPAGAGVVARLAERCPCPPERAELAATTGATLLELLERFPSCAVD
LALALELLPAPRTRLYSISSAAEEQRAEVALTVSVTGVTSGYLSRVRPGDRVAVGIAS
PPESFRPPADNTVPVVLIAAGTGIAPFRGFLRARAALGGEPGPALLLFGCRGPELDDL
YAEEFAALGDWLEVDRAYSRHPDGEVRHVQHRLWQRRDRVRELVDAGARVYLCGDATR
VGPAVEEVLGRIGPGAGWLDALRAGGRYATDVF

CYP102G1    Streptomyces scabies
            SCAB5931  
            David Lamb
            Submitted to Nomenclature committee Nov. 10, 2006
            52% to 102A5 Bacillus cereus P450 part
            52% to 102A3 Bacillus subtilis, 45% to 102D1

CYP102G2    Saccharopolyspora erythraea NRRL23338
            SACE_4205, 4676800,4679985 (-) STRAND
            56% to CYP102G1 Streptomyces scabies, 51% to CYP102B2
MTQTPLHHDDVPVADVSGTGLTATPTQQAMELARRHGPVFRRRTREFQSLLVSDVDLVAE
LSDEQRFAKAVGPALENVREFAADGLFTAYNDEFNWAKAHDILMPAFALGSMRTYHPVML
RVARRLLDSWDRAAAASAPVDVPDDMTRMTLDTIGLAGFGFDFGSFGRAEPHPFVGAMVR
CLDWSMTRLSRVPGTDHSERDEAFRADARYLASVVDEVINTRAAEGDTSGEDLLGLMLGA
RHPADGTTLDAANIRNQIITFLIAGHETTSGTLSFALHYLAKNPTVLRLVQREADELWGD
SPDPEPSFEDIGRLTYTRQVLNETLRLWPSAPAFGRQARHDTVLGGRIPMRAGEAAAVLI
PMLHRSPVRGDNPELFDPARFAPEAEAARGPHAFKPFGTGERACIGRQFALDEATMVLAM
LAHRYRLVDHAGYRLKVKETLTLKPEGLTLAVRARTAADRVTNRLALPVGLPSAAPGEPA
DAARRPGRVLPGTGLLLLHGSNYGTCRDFAAQLALAAGELGCDTAVAPLDEYAGNLPSDR
PVIVVAASYNGRPTDDAVSFSRWLDEAEPGAADGVDFAVLGVGDRNWAATYQHVPTRIDA
RLAELGGTRILERGEADASGDLAGAVRRFSAALETALLERSGDPDAVAAAPEGDGPAYTV
SEVTGGALDSLAARHGMVEMTVTEVADLTAPDYPRTKRFVRLALPEGTAYRTADHLAVLP
VHDAALVERAAGVLGVDLDTVLDIRAKRPGRLTFDRSLTVRELLSHHVELQDPPTPDGLD
ALAALNPCPPERAALRGLAEEARSGTADHRTLWDLIEDHPALRDALSWSALLELLPATRP
RQYSVSSSPAVDPRHVDLMVSVLRAPARSGRGEFRGAGSRHLSEVRPGDTVLARVQPCRE
DFRVAPDEPLIMVAAGTGLAPFRGVIADRRERVANGARQAPALCYFGCDAPDADYLHSAE
LRAAESAGAVAMRPAFNEAPVGGQCFVQHRIAAEAGEVWALLESGARVLVCGDGRHMAPG
VREAFRGIYRERTPGADDASAHEWLQAMIAGGCYVEDVYAG 

CYP102G3    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY587 67% to CYP102G2

CYP102H1    Nocardia farcinica IFM 10152 plasmid pNF1 
            GenEMBL AP006619 177679..179100
            51% TO 102C1
MAVTTSTTSGGHSNPPLPHPKWRLPIINDLLTINPIKPTLTSLR
DAEQLGGIFERRLVDWPMIVVSDSELITEICDERNWAKHLGVPLRKMRHIARDGLFTA
RNDEPNWAKAHAVLAPAFTKEAMRSYHQTMLTTIGELLDYWAKRDGQWVDVGEDMNKL
TLEIIARTGFDYTFDSFTRSEVHPFVAAMLRGLTYISRNSNMPPFLQKTIGARAAARH
SRDITYVRTVVDDVIKARQASGTVGDHHDLLDRMLTVPDPASDELLDTTNVRSQILTM
LVAGHETSAGVLAFALYELSRRPELVAAARAEIETRFADGDLSTIAYDDVAKLRTLRR
IVDETLRLYPVAPGFFREARHETTIGGGRYRFGPGDWVLVLTLHAHRDPATWGPDAGE
FQPDRWLPERMRSLDGRQVFKPFGTGLRACIGRQFAYHEIVLALAHILHTFEFTPDPG
YELDIAEQITLKPHRFRLRLNHR

CYP102J1   Burkholderia sp. 383
           ABB05850
           50% to CYP102A4 
  1 MKSSSLVPQP PLKPVIGHLM EVLGPSPLAK MMDLARTYGP VYWFEVFGQG YYVVSGQTLV
 61 DEVCDETRFQ KCVHQSLLEL RPAIGDGLFT AFGDEPNWAK AHRVLMQAFG PLSIWSMFDK
121 MVDIADQMFL HWERFGPETP VDVSDHMTRL TLDTIALCAF DCRFNSFYRE DQHPFVDAMV
181 NTLSEAGKRE LRPKLVSKLM VKRSRQFDAD IEVMRSLATK MIEDRRKNPH VNEESMDLLD
241 RMLNGIDPVT GEKLDDENIV FQMITFLIAG HETTSGLLSF ATYFLLKNPD ILQKARDMVD
301 EVVGSETPRI EHLARLRYVE QILMETLRIW PTAPGFAVKP LADTTFGGKY AVSPDDIIMI
361 LTPMLHRDVS VWGEDVEAFR PERFAPENAE QLPPNSWKPF GNGARACIGR PFAMQEAHLV
421 LIMLLQRFDF SFADPDYELD VAETLTLKPA GFRVNVKPRA RGALKVPDTA LHARSNAQSP
481 SVAPVQSIAP GEDLSNLLVL FGGNTGSAES FARRIAGDAS RHGFHATCAP LDDFAGKLGG
541 YPAIVIVTAS YEGQPPDNAK SFVPYVEALD EGALDGVHFS VLGCGNKQWA RTYQAIPKRV
601 DEALEKAGAT RVHFRGELDS GGDFFGEFDR WYTEMWNRFA ISAGKEIPVI QHDDVALKVS
661 FAGSSREKVL NLGDMAHASI VDNRELVDIS VAGSRSKKHI ELKLPEAMTY RSGDYLAVLP
721 RNAKNNVDRV LRRFRVSWDT QVVIEGTSSN PRLPLGQAIG CGELFSSYVE LAVPATRSQV
781 SSLAAATRCP PEKVELERLS ADGFECEILG KRTTVMDLLE RFGSVDLSLE KFLDMLPALK
841 ARQYSISSSP LWKADHVTLT VAVVDAPALS GNGRHEGVAS SYLARLNTGD SLSVAVRPSN
901 ARFRPPAEPD LPMILICAGS GIAPFRGFLQ ERALQKQRGE NVGTSLLFFG IDDPDVDFLY
961 RDELDEWARC GVVEVMPAYS NRPEEGARFV QDKVWLERER ISALFSQGAT VFVCGDGKNM
1021 APAVRATLGR IYQETTGEND ESASAWIDTM EREHGRYVAD VFA

CYP102K1 Azorhizobium caulinodans
         AP009384.1 (protein BAF89518.1)
         39% to CYP102F1 Actinosynnema pretiosum subsp. auranticum (P450 part)
         39% to CYP102E1 Ralstonia metallidurans (P450 part)
         top 31 blast hits are all CYP102 family members

103 Family

CYP103A1     Agrobacterium tumefaciens
             GenEMBL M19352, AF242881 CDS 141158.142426 
             gene="virH1"

CYP103A2     Agrobacterium tumefaciens
             GenEMBL AF034769
             GenEMBL AB016260 CDS 124584..125759

CYP103A3   Agrobacterium tumefaciens plasmid pTiAB2/73 vir region
           GenEMBL AF329849 892..2148
           gene = virH
           61% TO 103A1
MNARGPEKVSQTSGPIISASLDPDNVSVSDLDRSGHAIFAEWRP
KRPFLRRQDGVYVLLRADDVLGLSSDPRTRQIETELMLNRGINEGAVFDFVRYSMLFS
NNEVHSRRRSPFTRTFAFRMIENLRPQVSQLTETLFQDLKELDSFNFVEEFASKLPAV
AIAGLLGLPPSDIPYFTQLVYRVARCLSPSWRDADLPDIEASAAEFKNYVQAVIDDRR
SNPRDDFLSSFIRATREAEDLSPDEGLAQLMLIVLAGTDTTKTGLTALTGQLLRHRHV
WEALLKDESLVPAAVEEGLRFEPPVGSYPRLALADIDLEGFILPKGSLLALCTMSALR
DEKHFAHPELFDIHRKQMHWHMVFGAGAHRCLGEALARLELQEGLATVLRYAPTLSIE
GEWPTVQGHGGVRRIAEMRVGFRRQI

104 Family

CYP104A1     Agrobacterium tumefaciens
             GenEMBL M19352, AF242881 CDS 142447..143670 
             gene="virH2"

CYP104A2    Agrobacterium tumefaciens
            GenEMBL AB016260 
            103A2 CDS 124584..125759 and 
            104A2 CDS 125919..127094 83% to 104A1

105A Subfamily

CYP105A1    Streptomyces griseolus
            GenEMBL M36480 (1629bp) Y18556 CDS 2447..3703
            Omer,C.A., Lenstra,R., Litle,P.J., Dean,C.R., Tepperman,J.M.,
            Leto,K.J., Romesser,J.A. and O'Keefe,D.P.
            Genes for two herbicide-inducible cytochromes P-450 from
            Streptomyces griseolus
            J. Bacteriol. 172, 3335-3345 (1990)
            Gene suaC

CYP105A2    Amycolata autotrophica
            GenEMBL D26543 (1197bp)
            Kawauchi,H., Sasaki,J., Adachi,T., Hanada,K., Beppu,T. and 
            Horinouchi,S. 
            Cloning and nucleotide sequence of a bacterial cytochrome P-450 
            VD25
            gene encoding vitamin D-3 25-hydroxylase
            Biochim. Biophys. Acta 1219, 179-183 (1994)

CYP105A3    Streptomyces carbophilus
            GenEMBL D30815 PIR JC4287
            Watanabe,I., Nara,F. and Serizawa,N.
            Cloning, characterization and expression of the gene encoding
            cytochrome P-450sca-2 from Streptomyces carbophilus involved in
            production of pravastatin, a specific HMG-CoA reductase inhibitor
            Gene 163 (1), 81-85 (1995)

105B Subfamily

CYP105B1    Streptomyces griseolus
            GenEMBL M36481 (1688bp) M32239
            Omer,C.A., Lenstra,R., Litle,P.J., Dean,C.R., Tepperman,J.M.,
            Leto,K.J., Romesser,J.A. and O'Keefe,D.P.
            Genes for two herbicide-inducible cytochromes P-450 from
            Streptomyces griseolus
            J. Bacteriol. 172, 3335-3345 (1990)
            Gene subC, SU-2

CYP105B2    Streptomyces tubercidicus strain R-922 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Cyp229
            78% to 105B1

CYP105B3    Saccharopolyspora erythraea NRRL23338
            SACE_2842, se: 3099326,3100528 (+) STRAND
            55% to CYP105B2, 54% to 105Q1, 53% to 105B1 
MTSTLDESTPDYPMPRARGCPFDPPPALRDLQRETPMARVRLWDGSTPWLVTRYADQRAV
LRDSHVSADMNHPTYPRQAPGGGTLSFIGMDDPEHARLRRMVGSAFAVKNVERMRPWVQR
IVDEAVDELLAGPRPADLVEEFALPVPSLVICGLLDVPYADHAFFQSNSKTMINRDSTPE
QRSQASGRLAEYLSDLLSSKMDTRGDDLRSRLCGRIEAGDLTLRQATEMAVLLLIAGHET
TANMIALSTLLLLRHPDQLALLRESDDPDVARRAVEEMLRYLNITHGGRRRVALEDVEVA
GQRVRAGEGLVLPNEIANRDPDAFPDPDRLDITREARHHVAFGFGVHQCLGQPLARLELE
IVYRTLYRRAPRLALAAGIEDIPFKHDGFVYGVYELPVTW 

CYP105B4   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7395 
           59% to CYP105B3 Saccharopolyspora erythraea NRRL23338 

CYP105B5    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE9048 66% to CYP105B2

CYP105B6    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE1311 60% to CYP105B3

CYP105B7    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY920 64% to CYP105B3

CYP105B8    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2570 59% to CYP105B3

CYP105B9    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY7881 66% to CYP105B3

CYP105B10   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY8448 81% to CYP105B4

CYP105B11   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY8453 57% to CYP105B3

CYP105B12   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY8455 64% to CYP105B3



105C Subfamily

CYP105C1    Streptomyces sp.
            GenEMBL M31939 PIR S19629 (381 amino acids)
            Horii, M., Ishizaki, T., Paik, S.Y., Manome, T. and Murooka, Y.
            An operon containing the genes for cholesterol oxidase and a
            cytochrome P-450-like protein from a Streptomyces sp.
            J. Bacteriol. 172, 3644-3653 (1990)
            Gene choP

105D Subfamily

CYP105D1    Streptomyces griseus
            GenEMBL S45823 X63601 (1700bp) PIR S24750 (412 amino acids)
            Trower,M.K., Lenstra,R., Omer.C., Buchholz,S.E., and 
            Sariaslani,F.S.
            Cloning, nucleotide sequence determination and expression
            of the genes encoding cytochrome P-450soy (soyC) and 
            ferredoxinsoy (soyB) from streptomyces griseus.
            Mol. Microbiol. 6, 2125-2134 (1992)
            PIR S35901 (412 amino acids)
            Erratum. Cloning, nucleotide sequence determination and
            expression of the genes encoding cytochrome P-450(soy)
            (soyC) and ferredoxin(soy) (soyB) from Streptomyces griseus.
            Mol. Microbiol. 7, 1024-1025 (1993)

CYP105D2    Streptomyces griseus
            GenEMBL AF071145
            84% identical to 105D1 partial seq.

CYP105D2    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR264
            One amino acid difference with partial sequence
            This is a complete sequence

CYP105D3    Streptomyces sclerotialus
            GenEMBL AF071149
            68% identical to 105D1

CYP105D4    Streptomyces lividans 
            GenEMBL AF072709 CDS complement(1593..2813)
            69% to 105D1 67% to 105D2 82% to 105D3 57% to 105A1 

CYP105D5    Streptomyces coelicolor 
            3StF60 [Full Sequence] Sanger cosmid 
            CDS comp(2106-3344) 98% identical to CYP105D4
            cloned and expressed by David Lamb and Steve Kelly

CYP105D6   Streptomyces avermitilis
           GenEMBL AB070949.1 69121-70371
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV412_pteD 55% to 105D1 from Streptomyces griseus,
           53% to 105D4, 54% to 105D5 (if first 17aa left off 105D5)
           Gene = pteD

CYP105D7   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV7469 73% to 105D4 from Streptomyces lividans

CYP105D8    Streptomyces tubercidicus strain I-1529 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Cyp233
            68% to 105D7

CYP105D9   Streptomyces sp. JP95
           GenEMBL AF509565 11774..13024
           griseorhodin biosynthesis gene cluster
           55% to 105D6
           gene = grhO3
MTDTLDEPQTLADGAEDAPAYPVKRTCPYRMPPGYEELREKGPI
SRVTLWNGRTAWLVTGNDLGRRLFPDARLSSDVLDPRFPLLAPRIEAQRQQAAAPPLV
GVDDPVHARQRRMVLPSFGIRQINALRPEIQKYADDLLDTMLAKGPGVTVDLLTEYAL
PMPSAVICMLLGVPYEDHHYFDERSRHVLSSSGEEQAAQAQQAFTEILAYLDDLIVRK
QAEPGDTLLDELIARQLEEGKVDRQELAMIATVLLVSGHETTSNMIALSTMALLADPD
QLAALRADESLMPRAVDELMRFSSIGDMLMRVAKEDIEIEGHLIRAGDGVILSTMLMN
RDPGAFERPDELDIRRPAGRHVAFGYGIHQCIGQNLARAEMEIALATLFRRVPTLKLA
VPAEQVPVNAPFVLQGVSELPVTW

105E Subfamily

CYP105E1    Rhodococcus fascians
            GenEMBL Z29635 (7139bp) PIR S42052 (399 amino acids)
            Crespi,M., Vereecke,D.M., Temmerman,W.G., Van Montagu,M.
            and Desomer,J.
            The fas operon of Rhodococcus fascians encodes new genes required 
            for efficient fasciation of host plants.
            J. Bact. 176, 2492-2501 (1994)
MAGTADLPLEMRRNGLNPTEELAQVRDRDGVIPVGELYGAPAFL
VCRYEDVRRIFADSNRFSNAHTPMFAIPSGGDVIEDELAAMRAGNLIGLDPPDHTRLR
HILAAEFSVHRLSRLQPRIAEIVDSALDGLEQAGQPADLMDRYALPVSLLVLCELLGV
PYADRDELRDRTARLLDLSASAEQRAVAQREDRRYMATLVTRAQEQPGDDLLGILARK
IGDNLSTDELISIISLIMLGGHETTASMIGLSVLALLHHPEQAAMMIEDPNCVNSGIE
ELLRWLSVAHSQPPRMAVTEVQIAGVTIPAGSFVIPSLLAANRDSNLTDRPDDLDITR
GVAGHLAFGHGVHFCLGHSLARMTLRTAVPAVLRRFPDLALSPSHDVRLRSASIVLGL
EELQLTW

CYP105F1    Streptomyces lavendulae 
            GenEMBL AF127374 CDS 2006..3229
            48% to 105C1 42% to 105B1 40% to 105D1 new subfamily in 105

CYP105F2   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           85% to 105F1
           clone name SP8812

CYP105G1    Amycolatopsis mediterranei 
            GenEMBL AF040571 CDS complement(5011..6066)
            49% to 105C1, 105B1 new subfamily in 105 
            looks like an insertion in the seq from 80-120

CYP105H1    Streptomyces noursei ATCC 11455 nyst 
            GenEMBL AF263912 CDS comp (58637..59833)
            gene="nysN" 47% to 105B1 46% to 105A1 46% to 105D1 
            function="presumably involved in modification of the
            nystatin macrolactone ring"

CYP105H2    Streptomyces albus
            GenEMBL AF071143 
            77% to 105H1
LLIAGHETTANNIGLGVVTLLSHPQWAGDERAVEELLRLHSVAD
MVALRVAVDDVEIAGQVIRKGEGIVPLLAAANHDTEVFGCPHAFDPERSERRHVAFGY
GVHQCLGQNL

CYP105H3   Streptomyces natalensis 
           GenEMBL AJ278573 52789..53985
           pimaricin biosynthetic gene cluster.
           68% to 105H1
           gene = pimG
MTYTDPAAPETDPPAVDFPQRKPGVPFPPPDYADYRDRKGLVLS
QLSDGKRVWLVTRHEDVRAVLTSPSISSNPEHKGFPNVGNLGVPKQDQIPGWFVGMDS
PEHDRFRKALIPEFTVRRVRAMKPAIERTVDAQLDAMLAAGNTADLVADFALPIPSLV
ISALLGVPPADREFFESRTRVLVSLRSSTDDDRMAAAKDLLRYINRLVEIKQKWGGDD
LITRLLATGAIAPHEMSGVLMLLLIAGHETTANNIALGVVTLLANPQWIGDDRAVEET
LRFHSVADLVSLRVAVQDVEIAGQLIKAGEGIVPLVAAANHDENAFECPHAFDPSRSA
RHHVAFGYGVHQCLGQNLVRIEMEVAYRKLFERIPNLELAVPTDGLDIKYDGVLYGLN
ELPVRW

CYP105H4   Streptomyces nodosus 
           GenEMBL AF357202 complement(62051..63250)
           amphotericin biosynthetic gene cluster
           84% to 105H1
MTAETEMTTFAPGCPVAFPLRRPGRPFPPPEYADYRAGEGLVRS
ELPASGPVWLVTRHEDVRTVLTDPRISADPSRPGFPRARRTGGAPSQSEIPGWFVALD
PPEHDRFRKTLIPEFTVRKVRELRPAIQQIVDERIDALLAAGNSADLIADFALSVPSL
VISDLLGVPKADRDFFEAKTKVLVTLSSTDEQRDEASKALLRYLNRLIQIKGRRPGED
LISRLLQAGTMNRQELSGVSMLLLIAGHETTANNIGLGVVQLLTNPQWIGDDRIVEEM
LRYYSVADLVSFRVAVEDVEIGGQLIKAGEGIVPLIAAANHDGSVFDKPEEFNPERSA
RSHVAFGYGVHQCLGQNLVRVEMEIAYRTLFERIPTLELAVPVEELPLKYDGVLFGLH
ELPVTWS

CYP105H5   Streptomyces griseus 
           GenEMBL AJ300302 10678..11859
           Gene = canC
           72% to 105H3
MTTSPGPTVVDFPRRTPREPLPLSQYAEHRKQNGLVQTHLPNGR
PIWLVTRHEDVRAVLTHPRISANPDNEGFPNVGETMGVPKQEQIPGWFVGLDSPEHDR
FRKVLIPEFTVRRVRELRPAIERTVDERIDAMLAGGNTADLVNDFALPVPSLVISALL
GVPSADRDFFESRTRTLVAIRTSTDEERAEATRQLLRYINRLIVIKKKWRGEDLISRL
LSTGKLSDEELSGVLLLLLIAGHETTANNIGLGVVTLLSHREWIGDDRLVEELLRLHS
VADMVALRVAVDDVEIAGQTIRKGEGIVPLLASANHDTEAFGCPHAFNPERTERRHVA
FGYGVHQCLGQNLVRVEMEIAYRKLFERIPELRLAVPEDQLAYKYDGILFGLHELPVR
W

CYP105H6   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_4165 
           67% to CYP105H4 Streptomyces nodosus

CYP105H7    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY1473 66% to CYP105H4

CYP105J1   Amycolatopsis mediterranei rifamycin 
           GenEMBL AF040570 CDS comp (67462..68673)
           52% to AF072709 105D4 50% to 105D1 new subfamily in 105

CYP105K1   Streptomyces tendae strain Tue901 
           GenEMBL Y18574 CDS 6325..7557
           45% to 105A3 46% to 105D1 43% to 105B1 new subfamily in 105
           gene="nikF"

CYP105K2   Streptomyces ansochromogenes
           GenEMBL AF469953  14..1246
           95% to 105K1
           note="involved in nikkomycin biosynthesis
MTEAFDHDIPSFPMARECPMHPPAEYRELRGQEPVSRVRMPDGQ
VAWLVLKHALARKLLADPRVSADRLHPAFPGRLTAEQRAATERVRRLTTRRSMIHLDG
DEHGAHRRILTGEFSLRRIAAQRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIQERAAASDALNDFLEALVTEKERGEPADD
LIGRLIARNRQTPVMTHDEIVGTAVMLLVAGHQTTANMISLGVVALLENPEHKARIAA
DSSLLPPAIEEMLRYFSVVENAPARVATEDIAIGGVTIRKNEGIVVSGLAADWDDEVF
GHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC

CYP105L1    Streptomyces fradiae 
            GenEMBL AF055922 CDS comp (6507..7769)
              GenEMBL AF147703 complement(2565..3875)
            Fouces,R., Mellado,E., Diez,B. and Barredo,J.L.
            The left edge of the tylosin gene cluster from Streptomyces 
            fradiae
            Microbiology (1999) In press
            tylH1
            46% to 105A1 42% to 105D1 43% to 105B1 new subfamily in 105
MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFS
PPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDG
EAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRDVRPSVEQIVTGLLDDLTARGDEAD
LLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRL
ISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL
QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLL
AAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA
LRPTTDVAGLRLKSDSAVFGVYELPVAW

CYP105L2   Micromonospora griseorubida
           GenEMBL AB089954 1490..2641
           gene cluster for the polyketide macrolide mycinamicin
           54% to 105L1
           gene = mycCI
MDRTCAWALPEQYAEFRQRATGWPAKVWDGSPTWLVSRYEHVRA
LLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMR
PEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELAS
RPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVL
LLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA
TADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLG
QNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW

CYP105M1    Streptomyces clavuligerus clavulanic 
            GenEMBL AF200819 CDS 136..1359
            GenEMBL AY034175 CDS 200..1423
            GenEMBL U87786 CDS 13810..15036 
            function="involved in clavulanic acid biosynthesis"
            48% to 105B1 42% to 105A1 41% to 105D1 new subfamily in 105
MNEAAPQSDQVAPAYPMHRVCPVDPPPQLAGLRSQKAASRVTLW
DGSQVWLVTSHAGARAVLGDRRFTAVTSAPGFPMLTRTSQLVRANPESASFIRMDDPQ
HSRLRSMLTRDFLARRAEALRPAVRELLDEILGGLVKGERPVDLVAGLTIPVPSRVIT
LLFGAGDDRREFIEDRSAVLIDRGYTPEQVAKARDELDGYLRELVEERIENPGTDLIS
RLVIDQVRPGHLRVEEMVPMCRLLLVAGHGTTTSQASLSLLSLLTDPELAGRLTEDPA
LLPKAVEELLRFHSIVQNGLARAAVEDVQLDDVLIRAGEGVVLSLSAGNRDETVFPDP
DRVDVDRDARRHLAFGHGMHQCLGQWLARVELEEILAAVLRWMPGARLAVPFEELDFR
HEVSSYGLGALPVTW

CYP105N1    Streptomyces coelicolor 
            St4C2 [Full Sequence] Sanger cosmid 
            CDS 29986-31221 45% to 105A1 new subfamily in 105
            cloned and expressed by David Lamb and Steve Kelly

CYP105N2    Streptomyces glaucescens cytochrome P450
            GenEMBL AF071144
            95% to 105N1 only 5 aa diffs
            57% to AF071148 56% to AF071146 59% to 105D3 54% to 105A3 
LLIAGHETTTSMIALSTLLLLDRPELPAELRNDPDLMPAAVDEL
LRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD
NHHVAFGYGMHQCLGQNL

CYP105N3   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           91% to 107N1
           clone name SP0881

CYP105P1   Streptomyces avermitilis
           GenEMBL AB070949.1 67376-68575
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV413_pteC low 40% range to 105 subfamilies 
           Gene = pteC

CYP105P2   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           92% to 105P1
           clone name SP7863

CYP105Q1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV1611 49% to 105B1 from Streptomyces griseolus 
           46% to 105D4 and D5

CYP105Q2   Streptomyces sp. 
           GenEMBL BD133549
           78% to CYP105Q1 
  3 LIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHSGLRRVA 182
183 KGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGFGTHQC 350

CYP105Q3   Streptomyces sp.
           GenEMBL BD133546 
           77% to 105Q1
 139 MADTLTDAAPDTDGRVPEYPMPRATGCPLAPSPAAAELRGDRPITRVRIWNGSTPWLITR 318
 319 HADQRTLLTDPRVSNDDHEPDFPHVNAHRAAIAPHTPKLITNTDAPEHTRLRRSVNAPFL 498
 499 VKRIEAMRPAVQKIVDDLIDDMLAGPSPADLLTALALPVPSLVIAELLGVPYEDHHFFQE 678
 679 NSNRVLDNSLTAEEAQESSRALGGYLDTLFRTKLEQPGEDVLSEMGSKVKAGEMTHQEAV 858
 859 SMGVAMLIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHS 1038
1039 GLRRVAKGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGYGPH 1218
1219 QCLGQNLARLELQVVYGTLYRRVLTLRPAVPVDQLAFNHTGTTYGVKCLPVTW 1377

CYP105Q4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4762
           52% to 105Q1

CYP105Q4   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 105Q4 M. marinum = ortholog

CYP105Q5   Streptomyces scabies
           SCAB11341
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           92% to 105Q3 Streptomyces sp.

CYP105Q6   Mycobacterium vanbaalenii PYR-1 
           ZP_01205830.1, EAS26822.1 
           50% to 105Q3, 86% to CYP105Q7
MTETLAQEAVSVPEYPMERTAGCPFAPPQQMLEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVS VDDRREGFPHWNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVIQQVTDECIDEILA GPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLHQYLINLVEEKQ AHPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLENPEQAALLRDSDDPKFI ANAVEELMRYLSIIQNGQRRVATEDIEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRDATQQLG FGYGRHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYGVYELPVTW

CYP105Q7   Mycobacterium smegmatis
           MSMEG4843 TIGR 
           53% to CYP105Q1, 51% to 105Q3
           86% to 105Q6 M. vanbaalenii, 76% to 105Q4 M. marinum
           Formerly CYP105T1 but more similar to CYP105Q sequences
MSETLTQPSATDIPGYPMERAAACPFAPPPQMLDMNKAKGLSRVRIWDGS 
TPWLITGHEEARALFADSRVSVDDRRPGFPHWNEHMLATVHKRPRSVFTS 
DAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDECIDAILAGPQPADIVD 
KLALPVPTVVISEMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLH 
QYLIDLIEKKQAEPAEDAVSDLAERVTAGELSVKEAAQLGTGLLIAGHET 
TANMIGIGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQR 
RVAVEDIEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRDAGQQL 
GFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLA
YGVYELPVAW

CYP105R1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV7186

CYP105S1   Mycobacterium smegmatis
           MSMEG0758 TIGR 
           fas1
           52% to 105E1
           76% to 105S2 Mycobacterium vanbaalenii
MTQAQALPPLHIRRDAFDPTPELGEIRAGEGVHVTVNPFGMQVYLVTRHE
DVKTVLSDHERFSNSRPPGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQ
RLRRMLTPEFTIRRIKRLEPRIVEIVDAHLDAMESAGPPADIVADFALPI
PSLVICELLGVPYEDRTDFQQRSARQLDLSAPMPERLELQRQGRAYMRGL
VERSRTRPGDDILGMLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGL
GVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTTDVEL
AGVTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRRGAPGHLAFGHGVHHC
LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQSLAVAW

CYP105S2   Mycobacterium vanbaalenii PYR-1 
           ZP_01208508.1, EAS22074.1 
           52% to 105E1, 76% to CYP105S1
MSQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPP GFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARD GEASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGAR TNPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPA VEELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGH GVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW

CYP105S3   Frankia alni ACN14a
           YP_713209.1
           CAJ61641.1
           62% to CYP105S1 Mycobacterium smegmatis
MRRAQFDPISELSTARDTVGVCPVVTPFGVPAHLVSRYDDVREVLSDSVRFSTADRHALMPPDAAGPTEQ
EYAQARVGNLLAYDPPEHTRLRRMLTPEFTMRRMRALEPRIVDIVSAALDDVERAGRPADLVSTFALPVP
SLVICELLGVPYADRAEFQRRTVDQLDASHPPEHRLALQQASRAYMATLVERARRDPGEDILGMLVREHG
DDISAEELVGIASLLLLAGHETTANMLGLGTLALLRHPDQLARVRDDPASVEPAVEELLRWLSIVHAGIP
RTATTEVTIAGSTIAAGEHVVLALPGANRDPALVDDPDRLDITREPAGHVAFGHGLHHCLGAPLARLELR
IAYPALLRRFPGLALAVPYEQIAFRPYSVIHGLQALPVTW

CYP105S4   Frankia sp. CcI3
           YP_480704.1
           ABD10975.1
           75% to CAJ61641
           65% to CYP105S1 Mycobacterium smegmatis
MAAAPIVPLHIRRAQFDPIEELVRIRDTDGVCRVVTVFGIPAYLVSRYEDVREILADPGRFSNVNQWVVG
PGGPVLSDEEIAELRAGQMLAFDPPDHTRLRRMLTPEFTVRRMRGLEPRIRDIVDAALDEVERAGRPADL
VATFALPVPSLVICELLGVPYSDRAEFQQRTRRQIDASLPIEQRLALQREARAYMAGLVTRAQAAPGEDL
LGMLVREHGDELSTAELVGIASLLLVAGHETTSNMLALGTLALLRHPDQLAMVRDDPAQVEPAVEELLRW
LSIVPSGVPRTTTTEVEIAGHRIPAGEQLLLALPAANRDPALVGDPDRLDITRGAPGHVAFGHGVHHCLG
APLARMEMRIAFPALLRRFPDLALAVPYEQVAFRAHHVVHGLHALPVTW

CYP105T1    Burkholderia fungorum
            GenEMBL NZ_AAAJ02000095 
            8366..9610 gene = Bcep2217
            44% to 105H1
MRKTMTSAINDVRPQTTSTFPFARTGSPLHPPAEYARYRDGQPV
TRVQMWDGRYAWIFTRMEDVKAVLSSPHFSVVPSKPGYPFLTPARAATVKSYQTFITM
DPPDHTRFRRMLTRDFTQKRMEELRPQIAAYVNRLIDEMLARGSPGDLVSALALKLPV
TVVSMLVGVPYEDHEDLVKWSGQRLDLEQNPTVSESAADNMLAYFDGLLQRKERDPGD
GADMLSRLVIEQIKPGHLSRLEAIHMVNLLYFAGHETTANQIALGTLSFLLDPRQRAL
LENNPGLLKNAIEEMLRFHTISHYNSCRVATADVEVGGTLIREGEGAYALIMAANRDP
AAFPAPDRFDIERPNSQEHVAFSYGLHMCLGQPLARLELQVCFEALFRRLPRLRLAVP
LEELPFKREMYVYGLHALPVTW

CYP105U1   Streptomyces hygroscopicus strain NRRL 3602
           AY179507 complement(63940..65133)
           Geldanamycin biosynthesis gene cluster
           50% to 105B1 52% to 105B2 not 105S
           gene = gdmP
MDEIRDYPESRAAACPFSPPLGYEELRERSAVTRVRMWDGSTPF
LVTGYHEARAALGDSRFSADGTHKAMPRFVKFEVPAEVFNLGRMDDPEHARIRRMLTA
NFTIRRTEAMRPMIQGIVDGLLDRLIAQGPPADLVADFAFPLPSQVIGVMLGVSDADF
AEFQQASQGVMDFTASAEEMGAALGVMVDYVARMCAAKRADPGDDLLSRLIVDQELTG
GLTQQQVVATALVLLLAGHETTANMIALSTVLLLSHPEQLARLRADAGLMGNAVDELL
RYITIVQEGTGRVATEDVEVGGVLIPGGEGVIINLPSANRDPHFADAHELDLSRPNAR
EHVAFGFGVHQCLGQTLARVELQIALETLLRRLPTLRLEVPFDDLAFLYESMNFGVAR
VPVAW

CYP105V1   Streptomyces sp. HK803
           GenEMBL AY354515 36297..37508
           Gene = plmT4 
           43% to CYP105Q1
MSQLSSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDG
KEVWLITGYDEIRSIFTDPRISVDNTQPGYPWLSEQARTVVLTGGVKPVGRMDPPEHT
AMRRMLGQGFLVKKIQNMRGDVEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWV
LGVPPADKRLISLVPRLFDEDSGLEGAMEARAELFAYIDELITHRENQPGDDIISHLV
GYYQKGELSRVSVLTQSVTLIAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPA
AVEELLRYTVVTEFSSKRVAAADIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLD
VRRDAKQHLGFGAGIHTCIGKQLARMELEVVYGTLFRRIPELRLAVPFDQLVFRNTFD
VQGVRALPVTW

CYP105W1   Micromonospora echinospora
           GenEMBL AF497482 84045..85229
           Gene = calE10
           calicheamicin biosynthetic locus
           45% to CYP105K1 47% to 105D4
MPRRCPFGPPAEYARLRTERPVARLPMLGGNTAWVVSRYADVKR
VLSDPRMSADRRRAGFPRFAPTTESQRQASFANFRPPLNWMDPPEHTAARRQIVDEFA
ARRVRQLRPLVERVVDEHLDAMTAGRSSADLVPSFSYPVPSRVICEMLGVPYGEHAFF
ERRSTRMLSRGVPADERARCAREIREFLDGVVTDKERHPGDDVLSRLLAAQRAAGEPD
HEAVVSMAFVLLVAGHVTTSNMISLSVLALLTHPERLARLRAEPDRFPAAVEELLRYF
TIVEAATARTATADVTVGGVTIRAGEGVVALGQAANRDPAAFDRPDEFDPDRDARHHL
AFGYGRHICPGQHLARLELDVALSRLVRRLPGLRLTVDVDDLPLKEDGNIFGLHALPVAW

CYP105X1   Pseudonocardia autotrophica same as Amycolata autotrophica
           GenEMBL AF525299 2766..3974
           Gene = pauC
           P-450 gene cluster
           49% to 105A3
MAEDTLGQDFPMQRQCPFEPPKEYERLRAEQPISRVRMPDGTPA
WLVTLHEDVRTVLASPAFSSDLAHPGMPAVNPEIRTIARQQRPPFSRMDPPEHSFFRR
MLIPEFTVKRTKTLRAGIQSVVDGLIDDLLRKSPPVDLVDEFALPVPSLVICQLLGVP
YSRHEFFQQQARVILSRQSTREQVGAAFTALRAYLDTLVEEKLHTPGDDLTSRLATEH
LEPTGDVRRQDLVASCMLLLTAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEA
VEELVRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDI
HRGNRRHACFGYGVHQCIGQHLARTELEVAFSTLFTRIPTLQIAAPSDELDYDHDGML
FGLHELPVTW

CYP105X2   Amycolata autotrophica same as Pseudonocardia autotrophica
           GenEMBL AF071148
           99% to 105X3 94% to 105X1 61% to 165B2
LLIAGHETTSHMISLGVTALLERPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL

CYP105X3   Micromonospora inyoensis 
           GenEMBL AF071146
           99% to 105X2 61% to 165B2 60% to 105A3
LLIAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL

CYP105Y1X   Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha04313
            Submitted to nomenclature committee 12/13/04
            Name changed to CYP105AA3
            48% to CYP105X1, 46% to 105D7 

CYP105Z1    Streptomyces scabies
            SCAB17851
            David Lamb
            Submitted to Nomenclature committee Nov. 10, 2006
            49% to 105B1 Streptomyces griseolus
            51% to 105B2 Streptomyces tubercidicus possible ortholog

CYP105AA1   Streptomyces tubercidicus strain R-922
            GenEMBL AY549204
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Jungmann,V., Molnar,I., Hammer,P.E., Hill,D.S., Zirkle,R.,
            Buckel,T.G., Buckel,D., Ligon,J.M. and Pachlatko,J.P.
            Biocatalytic conversion of avermectin to 4'-oxo-avermectin:
            characterization of biocatalytically active bacterial strains and
            of cytochrome p450 monooxygenase enzymes and their genes
            Appl. Environ. Microbiol. 71 (11), 6968-6976 (2005)
            Submitted to nomenclature committee June 2, 2003
            Clone name Cyp230
            56% to CYP105AA2
            formerly 105S1, but that name was already assigned to 
            a Mycobacterium smegmatis sequence (my error).
MTGRSACGSGARSAPSVRTPASPPVGPSAAPVTPVTPSQPLTLL
EKDCPMTAMQPTARTQPMERTCPFSPPEGYRTLREEDPITQVTFPDGAKGWLVSRYSD
VRAVLADPRFGANGQQPPLPGMFLTMDPPEHTRFRRLLTGQFTVRRMRKLAPAVEQIV
AERLAEMAAAEGPVDLVQAFALPVPSLVICELLGVPYADREEFQENSSRMLRLDASQE
QFEQAQMAMYERIHQLVVAKRAHPTDDILSGLVQSGVLTDEEVTGVGVLLLIAGHETT
ANMIALGTMCLLGHPGQLASLRADPELMDDAVEELLRYLTIVQYGLRRMALEDVELGG
QRIKAGSVVVAALPSGNRDATHFSGDPETLDVRRPYSPHLAFGHGVHQCIGQQLARVE
MKAALSALIDRFPGLRLAVPAREVPMRDDMLIYGVHELPVTW

CYP105AA2   Streptomyces tubercidicus strain I-1529
            GenEMBL AY549201, GenPept AAT45294
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Jungmann,V., Molnar,I., Hammer,P.E., Hill,D.S., Zirkle,R.,
            Buckel,T.G., Buckel,D., Ligon,J.M. and Pachlatko,J.P.
            Biocatalytic conversion of avermectin to 4'-oxo-avermectin:
            characterization of biocatalytically active bacterial strains and
            of cytochrome p450 monooxygenase enzymes and their genes
            Appl. Environ. Microbiol. 71 (11), 6968-6976 (2005)
            Submitted to nomenclature committee June 2, 2003
            Clone name Cyp234
            56% to CYP105AA1
            formerly 105S2, but that subfamily was already assigned to 
            a Mycobacterium smegmatis sequence (my error).
  1 MTRTVPGPQA LPTERDAGPF APPRDISRMR EARPVSPMVF PDGHEGWIVT GYDAVRRLMA
 61 DTRFSSRQDI GILHVPYETP GMPAPTEPSP QIPGLFIAMD PPDHTRLRRK LTGAFTVKRM
121 KQLEEHISDI VERQLDELTR LAPPVDLVKE FALPVPSLVI CALLGVPYAD RETFQVNSAK
181 FLEKDVSLDE KMAAYTGLTT YLSELVTRKR AAPGEDILSD LARHDDLTIE ELTGMAFLLL
241 LAGHETTANM LALGTFALLE HPEQLAELRA DPDLMPGAVE ELLRYLSIAD IFYRYATEDI
301 ELGGETIGKG STVVVSLLAA NHDPQRFDNP DTLDIHRTAR GHLSFGHGIH QCLGQQLARI
361 EMRAGFEGLL RRFPTLELAI PADEVKLKTD MNIYGVHELP VTWTDTAR

CYP105AA3   Rhodococcus jostii RHA1 
            YP_702567
            Marianna A. Patrauchan
            Rha04313
            Submitted to nomenclature committee 12/13/04
            Formerly CYP105Y1
            84% to CYP105AA2, 48% to CYP105X1, 46% to 105D7 
  1 MSKTVAVPYG LPMERDAGPF DPPRRITRLR ETRPVSPMVF PDGHEGWLVT GYDAVRQLMA
 61 DTRFSSRQDI GILHVPYETP GMPAATEPSP QMPGVFIAMD PPDHTRMRRK LAGAFTVKRM
121 KQLEDHIIDV AERQLDAMAR LTPPVDLVKE FALPVPSLVI CELLGVPYAD RDNFQVNSAK
181 FLIKDQPLDD KMAAYGALST YLADLVTRKR AAPGDDILSD LARDDDLTIE ELTGAAFLLL
241 LAGHETTANM LALGAFALLE NPEQLTELRT DPDLLPDAVE ELLRYLSVAD IFYRYATEDI
301 ELGGETIRAG STVVVSLLAA NRDPQRFDNP DTLDIRRKAR GHLSLGHGVH LCLGQQLARL
361 EMRAGFEGLL RRFPTLGLAI PAGDVKLRTD MNIYGVHELP VTWTETSR

CYP105AA4   Amycolatopsis azurea 
            GenPept BAD91667
            80% to CYP105AA2
  1 MTETVPVPQG LPMQRDAGPF APPSEITRLR GARPVSPMVF PDGHEGWLVT GYDEVRQMMA
 61 DTRFSSRQDL GILHLPYETP GMPAPTEPSP PMPGMFVAMV PPDHGRLRKR LTGAFTVKRM
121 KQLEEHIVEI TEQHLDAMTK LVPPVDLVKE FALPVPSLVI CELLGVPYED RENFQANSAQ
181 LMVRDQTLEE KMAAFIGMNT FLTELVTRKR ETPGDDILSD LGRYDDLTIE ELAGAAFLLL
241 LAGHETTANM LALGTFALLE HPEQLAELRA DAELLPAAVE ELLRYLSVAD IFFRYATEDL
301 ELGGETIRAG STVIVSLLAA NRDPRRFENP DTLDLHRNAR GLLSFGHGVH QCLGQQLSRI
361 EMRAGFEGLL RRFPTLSLAV PADEVKLKTD MNIYGVHELP VTW

CYP105AA5   Streptomyces lydicus
            GenPept BAG50414.1
            79% to CYP105AA4
  1 MSRTVPVPQG LPMERDAGPF DPPRDLTRLR EARPVSPLLF PDGHEGWLVT GYEAVRRLMA
 61 DTRFSSRQDI GVLHVPYETP GMPVATEPSP QVPGLFIAMD PPDHTRLRRR LTGAFTVKRM
121 KMLEEHIHDI VERQLDAMAR LAPPVDLVKE FALPVPSLVI CEMLGVPYED RETFQVNSAK
181 FLVKDQPLDE KMAAYGALTT YLAELVTRKR ATPGEDILSD LARQDDLTVE ELTGIAFLLL
241 LAGHETTANM LALGTFALLE HPGQLAELRA HPELLPGAVE ELMRYLSVAD IFYRYATEDI
301 ELGGETIGKG STVVVSLLAA NRDPLRFDNP DALDVRRAAR GHLSFGHGVH QCLGQQLARI
361 EMRAGFDGLL RRFPTLELAL PADEVRLRTD MNIYGVHELP VTW

CYP105AA6   Rhodococcus opacus B4
            GenPept BAH51173.1
            78% to CYP105AA4
  1 MTVKQTHTVS VPHGLPMERD AGPFDPPGDI TRLRDARPVS PLIFPDGHEG WLVTGYDAVR
 61 QLLADTRFSS RSDLGIVHVP YETPGMPAAT EPSPQVPGLF IAMDPPDHTR LRRKLTGAFT
121 VRRMKQLEEH IADIVERQLD EMARLTPPVD LVQEFALPVP SLVICELLGV PYADRDTFQV
181 NTAKFLVKDQ ALDEKMAAYG ALTTYLAELV ALKRVTPGED ILSDLARDDD LTIEELIGIA
241 FLLLLAGHET TANMLALGAF ALLEHPEQLA ELRADPELMP NAVEELMRYL AVADIFYRYA
301 TEDIELGGET IGQGSTVVVS LLAANRDPRH FDNPDTLDLH RKARGHLSFG HGVHLCLGQQ
361 LARLEMRAGF AGLLRRFPAL ELAVPAGEVK LKTDMNIYGV HSLPVCLQPV STY

CYP105AA7   Actinosynnema mirum DSM 43827
            GenPept EEH76286.1
            69% to CYP105AA4
  1 MDLTSPIPIP DGLPQERDAG PFAPTTFVAD LRARRPVCPL VFPDGHVGWL VTGHAAVRQV
 61 LADTRFSSRL DLGVLHVPHP TPGMPQATEP SPQVPGLFVA MDPPDHTRLR RKLTGAFTVK
121 RMRALEERVA QVVEERLTAM AALTPPVDLV REFALPVPSL VICELLGVPY ADREVFQANT
181 ARFLVKDVEL AEKAAAYGAL TGYLAGLVAS KRAEPGEDVL SDLARHEDLT VEELTGCAFL
241 LLLAGHETTA NMVALGTFAL LEHPDQLAAL RAEPGLLGGA VEELTRYLSV GDLFYRYATE
301 DLELHGELIP AGSTVVLSLL AANHDPEAFE DAGALDVRRD ARGLVAFGHG VHQCLGQQLA
361 RVEMRAGFAG LLRRFPDLAL AVPAGEVPLK TDMNVYGVHA LPVTWGTAAG

CYP105AA8   Actinoplanes sp. ATCC 53771
            No accession
            Jamie Prior
            Submitted to nomenclature committee April 28, 2009
            93% to CYP105AA4, 81% to CYP105AA2

CYP105AA9   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2260 85% to CYP105AA2

CYP105AB1   Saccharopolyspora erythraea NRRL23338
            SACE_3429, se: 3784062,3785189 (+) STRAND, 
            52% to CYP105W1, 51% to 105K1
LRSQEPVKRVRTIGGGTAWLVTRHEDVRRVLSDPRMSSDRTMPGFPSLVPGRRAIVAENK
QAMIGMDGQEHAEARRAVIGEFTVRRINRMRPRIQEIVDECVDRMLAAGGPVDLVRELSL
PVPSLVICELLGVPYSDHDFFQSRSALMISRSTPPERRRDVVLELRRYLDELVAEKVREP
ADDLLGRQVAQQSEKGEVDREGLVSLAFLLLIAGHETTANMISLGTLALLDNPDQLARIT
EDPARTPAAVEELLRYFSIVDGATSRTALADIEIGGVLIREGEGVVAVGLSANRDPEAFD
SPDELDLDRQARNHVAFGFGAHQCLGQNLARVELQIVFDTLFRRIPGLRLADGLDGIRFK
DDALVYGAHEMSVTW

CYP105AB2    Salinispora tropica (marine actinomycete)
             Strop_1339 complement(1505346..1506596)
             57% TO CYP105AB1 Saccharopolyspora erythraea
             48% to CYP105K1 Y18574.1 Streptomyces tendae
MTETASIATTRTASGQLTDAEFPVQRGCPFTTPTEYEQIREESSIAKVRLKNGGEAWWIA
GHELGRSVLADRRFSSDRRRDNFPFVSTDPETRAQLQSQPTSMLGMDGAEHAQTRRALMG
EFTVRRMAGLRPRIQQIVDQHIDEMLATPQRSVDLVEALSLPVPSLVICELLGVPYADHD
FFQGLTGPLLRHTTPPEVRLRIQEELNTYLGTLIDRKLTDPTDDLLSRQIAKHRDNGTFD
RASMVSLAFLLLVAGHETTANMISLGVVGLLQHPDQLVIIKDDPDKTPLAVEELLRYFTI
ADSVTARVATEDVQLGDTTINAGDGVVISGLAADRDPTVFAEPDRLDLERGARHHVAFGF
GPHQCIGQTLARMELRIVFDTLFHRIPTLRLAAPLDDIPFKSDAFVYGIEELPVAW

CYP105AB3   Nonomuraea recticatena
            AB180844
            Gene name moxA
            64% to CYP105AB2 Salinispora tropica (marine actinomycete) 
MTKNVADELAGLELPVERGCPFAPPAAYERLRERAPINKVRLTS
GGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAE
HSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVI
CELLGVPYTDHDFFQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFS
RQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPG
RTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDP
AVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFK
GDSVIYGVHELPVTW

CYP105AC1   Saccharopolyspora erythraea NRRL23338
            SACE_4243, se: 4724009,4725226 (-) STRAND, 
            52% to CYP105AA2, 52% to CYP105AA1
MQKHAPHNADDVLESLPRDRPSGCPFDPPEGLAEIRGQRPLTRLVYGDGHVGWLATGHAV
VRAVLADRRFSSRYELMHFPVAMPGLPAQIPPAQVGDITGIDPPEHTRYRKLLTGKFTVR
RMRALTERVEQITAERLDAMQRLGPPVDLVEAYAQPIPALMICELLGVPYDRLEEFLGLV
AASGDRDLTPEEQFDAFAKIQEFVRELVPAKRAKPTDDLLSDLTTTELTDQELAGIGGLL
LAAGLDTTANILALGTFALLRNPEQIAALREGDADRAVEELLRYLSIAHTGMRSALEDVE
IDGTLIRAGETVTLSIQAANRDPRRFTDPDALDLRRHAAGHLSFGHGIHQCLGQQLARVE
MRVAFPALFNRFPGLRLAVAPEEVPLRGDMNIYGVHGLPVTWDGA

CYP105AD1   Frankia alni ACN14a
            YP_714282.1
            CAJ62727.1
            46% to CYP105AF1 YP_001507778 EAN1pec
            47% to CYP105A1 Streptomyces griseolus
MTQAPQYPQTRTCPYEPPPAYKEIGQEGPVVKVSLFDGRESWMVTGYRESREILTHPNLSSLRTHPNFPI
VAPRFRSPVARSLALLAMDPPIHDVYRRYLNPHFSLRSVRAMRPELERIIAGYVDRIIDHGPPADLIEML
AVPMPSLIICHHLGVPYADHDFFQDCSGKVMLAGEEEAGKAAQDLVEYLDNLVTEQQRNPTDGLIGQLVR
ERVSDGDIGHDELVSIALVLLIAAHETTASTLAIGIINLLGHPEELAKLRADISLLPGAIEELLRYVATT
DLVAVRIAKGDIEIAGHHIREGEPVLVSGTLANRDPQVHQRADEFDIQRDDTFHLTFGFGIHQCLGQNLA
RLEIELALRELITRLPGLRLAVPMEELPILSAGTVQRVLELPVEW

CYP105AE1   Frankia alni ACN14a
            YP_714292.1
            CAJ62738.1
            48% to YP_001507783 EAN1pec
            52% to CYP105A3 Streptomyces carbophilus
MNRVTLFDGATAWLVTGHSHSRRLLADPRVSADRSRPDFPVVLPRFEADVFKPLAIIGFDPPQHGLQRGL
LTADFSMRSVRAKRESIERLVESLADRMLAAGPPADLVLDYSLPIPSMVVADLLGVPYADHQFFEDATVR
LLQATTPQGAEAAGEELLNYLDEQIRLRERDPDDTLLSRLGEHVHDEGLGRDIINKIALALLVGGHDTTS
QMIALGVVTLLDHPDQLAILRSDPSALPGVVEELLRMVSVTDLAGVRVATEDVEIDGQVIARGEGLIFCN
SMANRDPAVYDAPYEFDVRRSADDPPATRRHLTFGHGPHQCIGRNLARMELEIAYRVLFEKIPNLRLAVP
RDELPMRHGSTMQGVHRLPVTW

CYP105AF1   Frankia sp. EAN1pec
            YP_001507778.1  
            ABW12872.1
            56% to CYP105D8 Streptomyces tubercidicus
MSSNQAVVATPPAFPMDRGCPYHPPAGYAQLQQDGPITRATLFDGREVWVVTGYEEARRLLVDPRLSSDR
SRPDFPVLVPRMAAAKLVALVGMDPPEHDIQRRMLIGSFTVRRANALRPDIERIVGGRVDALLAHEPGEV
VDLVPEFALPIPSTVICELLGVPYGDHEFFEEQTRRMVIATSTAAEAAAASRALVDYFDELIARKRERPG
EGLLDELIAERLVTGQIGQDDLASMAMFLLVAGHETTANMLGLSVLALLEHPDQRARLIEDPAGRAAGAT
EELLRFLSVADEIQRIAAADIEVAGVVIRAGDGVYLPTAAANRTAATFPDPDALDIGRVPRGHLAFGYGI
HQCIGQNLARVELEIGLRELFGRIPTLRLAEPVEALGAKPGGSVQGVYRLPVVW

CYP105AF2   Frankia sp. EAN1pec
            YP_001507783.1
            ABW12877.1
            54% to CYP105D8 Streptomyces tubercidicus
MTGTEIPEYPLARTCPFHPPAGYARYREHGPVNPVRLYDGRRVWAVTGHAEAREVLLNTRLFSSERADPR
YPATSPRFEAARKVRNFIGMDPPDHTAQRRMLQSSFTMRRINGLRPGIQRLVDELLDAIVAKGPVVDLVP
EFALPIPSIVISELLGVPYGDHAFFEQQSRRVASGTSTLEESADAFTQLLQYLDGLIQDKERSAGDGLLD
VLIAEQVRPGVLTRRELVDISLLLLVAGHETTASAIALGVVALLEHPDQLAALRADPALLPSAVEELLRF
TTIADSVARFATADTELAGQPVAAGDGVLVVLSAANRDGTVFPDPDLLDLARRARSHVAFGHGAHQCIGH
NIARAELEIAFSTLFARLPGLRLAVPLDRLPGKDAGGVQGVFELPVAW

CYP105AG1   Frankia alni ACN14a
            YP_714209.1
            CAJ62654.1
            41% to CYP105Q1 Streptomyces avermitilis
MTTRHLIDQPISRDLAHPLDPPAAYTELRENQPVVRARFPNGSTGWLVTRFEEGSQVFSDPRFSAKRRRH
DTPEGEQAEAGDDAPFDAGFVMMDEPDHGVYRRLLTARFTPKAVQTRLQPYLDRIVAEHLDAIAAGPETF
DFVQALSLPIPCLVICELLGVPYADRDGFHHATEVMMDTGVSRAERDRGAHWLVDYITALVADKRRTGDT
EGILAELIGKADDEGSILSERQLVGLGVLLLFAGHDTTAAMMGLSTLTLLTHPEQRRDLTEHPERIGTAV
EELMRYLTIVQFGLGRVAAQDVELGGAHIGRGELVVVAMNAANRDPRVFADPDALDLDRTMVRHLGFGYG
VHACLGQNVARAELRTVLPALFRRFPHLRLATPPNEVPMDFTGTNYGVRKLMVTR

CYP105AH1   Frankia sp. EAN1pec
            YP_001510028.1
            ABW15122.1
            46% to CYP105R1 Streptomyces avermitilis
MRELPPCAVRIPAGAADSRLAWLVTRYPDARQALMDPRLSADETLPGAPVRIQVPPDQKPGSFLRMDDPE
HARLRGTITTEFTARRVRGLRPAVQRLIDELLDGLAAGPRPTDLQDAFSRTLPTLVIARVLGVPDADSPF
FVEKTRVTISQGDTARSYAAYQEMSEYLGVLATRKQKEPADDLMSRLAVNHLATGKITLDELVGIARLVL
VAGHETTTNQIALNILSMLLDDDLRRTVLADDGVRIPQFVEESMRYWSISQDAIVRLAVEDFELGGTTMH
KGDAVVISIPAGNHDESMFPDPDRIDLDRDSGDHLQWGVGPHYCQGAPLARLEMELALKTLFGRFPGLRL
ATDDPDSVFRTGTVFHGVRELPVTW

CYP105AJ1  Frankia sp. CcI3
           YP_480220.1
           ABD10491.1
           47% to CAJ61641
           50% to CYP166B1 Streptomyces peucetius (probable 105 subfamily)
           47% to CYP105AA2 Streptomyces tubercidicus
MQNAHSDLRMSSRGDLLRSPIPLPMAGERTEPAPGMFTAMDPPEHTRYRRHIVEWFSTRRTRSLEPRVIE
IVDQHLDAMIAGGGPADLVSAFAEPVSALVICELLGVPVEQREVFGAAIAALFTVHSSAEEAISGWQNIG
GLLMGLIQAKRVASADDLLGTLVARGELSDEELMTIGSVLLVAGHDTSTNMIAMGTFALLEHPEQYAALA
ADPGLAPGAVEELLRYLTIVHAGSIRAVSADLEFDGHQLTAGDAVSLSLAAANRDPALCDAPDRLDITRE
PVPHLAFGHGIHQCVGQQLSRLELRIAFESLARRLPNLHVAVPTSEIRTRSEMIIYGVRELPVTW

CYP105AK1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_6930 
           47% to CYP105S3

CYP105AK2   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY4171 85% to CYP105AK1

CYP105AL1P  Frankia alni ACN14a
            YP_710901.1
            CAJ59294.1
            42% to CYP105AB1 Saccharopolyspora erythraea
MEAPLMTLSVESHLPSCPMERSSPFEPPPGYARARSEAPITKVRLVDGSTGWFVTGHALVRRLLNDPKVS
KNGLRPGYPPLVPDQEALVRGQKGFLVWMDPPDHTMYRRMLAGEFSVNTLERLRPHVEHIVNECIDQLLD
AGPPADLVQVLSLPVPTMTICELLGVPYTDRQLFQESTAATVNLRTTQEERNRTVAELRQCATRAGDRLP
HALPAAPGPARRAADALGADRLRAGRGRTGEDGLVVLLTEDPPEERRQEVIDAAGSCPAQAILVDGE

CYP105AM1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE8684 52% to CYP105AA1

CYP105AN1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE7349 51% to CYP105AA2

CYP105AN2   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY589 68% to CYP105AN1

CYP105AP1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE9554 50% to CYP105B2

CYP105AQ1   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY628

CYP105AR1   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2321

CYP105AS1   Amycolatopsis orientalis
            No accession number 
            Kirsty McLean
            Submitted to nomenclature committee Dec. 5, 2012
            53% to CYP105AA2 Streptomyces tubercidicus

CYP105 fragment  Streptoalloteichus hindustanus
            AF071147 
            66% to 105AA2, 63% to 105Y1
            61% to 105C1 59% to AF040570 CDS 2652..3842 (CYP166A1)
LLIAGHETTANMLALGAFALLEHPEQLAELRANPDLMPGAVEEL
MRYLSIVHIGPVRTAVADVEIEGQLIRAGESVTVSVPAANWDPAKFPEPERLDLTRRT
SGHLAFGHGVHQCLRQNL

106 Family

CYP106A1    Bacillus megaterium 
            GenEMBL X16610
            Gene BM-1

CYP106A2    Bacillus megaterium
            GenEMBL Z21972 (4317bp) PIR S32216 (410 amino acids)
            PIR S39924 (410 amino acids) Swiss Q06069 (410 amino acids)
            Rauschenbach,R., Isernhagen,M., Noeske-Jungblut,C., Boidol,W.
            and Siewert,G.
            Cloning, sequencing and expression of the genes for cytochrome
            P450meg, the steroid-15beta-monooxygenase from Bacillus
            megaterium ATCC 13368.
            Molec. Gen. Genet. 241, 170-176 (1993)

CYP106B1    Bacillus anthracis str. Ames
            Genpept AAP26480                 
            47% to 106A2 47% to 109B1
  1 MASPENVILV HEISKLKTKE ELWNPYEWYQ FMRDNHPVHY DDEQDVWNVF LYDDVNRVLS
 61 DYSLFSSRRE RRQFAIPPLE TRININSTDP PEHRNVRSIV SKAFTPRSLE QWKPRIQSIA
121 NELVKDIENC SEVDIVEQFA APLPVTVISD LLGVPTTDRK KIKAWSDILF MPYSKEKFND
181 LDAEKGIALN EFKAYLLPIV QEKRYHLTDD IISDLIRAEY EGERLTDEEI VTFSLGLLAA
241 GNETTTNLII NSFYCFLVDS PATYKEVREK PKLISKAVEE VLRYRFPVTL ARRITEDTNI
301 FGPLMKKDQM VVAWVSAANL DEKKFSQASK FNIHRIGNEK HLTFGKGPHF CLGAPLARLE
361 AEIALTTFIN AFEKIALSPS FNIEQCILEN EQTLKFLPIR LKPQ

CYP106B2P  Bacillus cereus ATCC 14579
           GenPept AAP09572  GenEMBL AE017006
83% to 106B1 54% to CYP109B1 YjiB Z99110 Bacillus subtilis I -helix
1 MTSVITDGEI VTFSLGLLAA GNETTTNLII NSFYCFLVDS PGIYEELRKE PNLILKAIEE
61 VLRYRFPVTL TRRITALSER ESPSPLGMG

CYP106B3P  Bacillus cereus ATCC 14579
           GenPept AAP09575 GenEMBL AE017006
87% to 106B1 54% to 106A2 C-term fragment 
   LKEDTNIFGPF
 1 MKKNQMIVAW VSAANLDEKK FSQASQFNVH RTGNEKHLTF GKGPHFCLGA PLARLEAEIA
61 LTTFINAFEK IELFPSFCLE KCILENEQTL KYLPIRLKAT

107A Subfamily

CYP107A1    Saccharopolyspora erythraea
            GenEMBL X60379 Swiss Q00441 (406 amino acids)
            Haydock S.F., Dowson J.A., Dhillon N., Roberts G.A., Cortes J.,
            Leadlay P.F.
            Cloning and sequence analysis of genes involved in erythromycin 
            biosynthesis in Saccharopolyspora erythraea: sequence similarities 
            between eryG and a family of S-adenosylmethionine-dependent 
            methyltransferases.
            Mol. Gen. Genet. 230, 120-128 (1991).

            Weber J.M., Leung J.O., Swanson S.J., Idler K.B., Mcalpine J.B.
            An erythromycin derivative produced by targeted gene disruption in
            Saccharopolyspora erythraea.
            Science 252, 114-117 (1991)

CYP107A1    Saccharopolyspora erythraea NRRL23338
            SACE_0730, 825267,826481 (-) strand
            EryF 6-deoxyerythronolide B hydroxylase (6-DEB hydroxylase)
MTTVPDLESDSFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTG
YDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLR
KLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELLGVD
EKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRV
QDDDDGRLSADELTSIALVLLLAGFEASVSLIGIGTYLLLTHPDQLALVRRDPSAL
PNAVEEILRYIAPPETTTRFAAEEVEIRGVAIPQYSTVLVANGAANRDPKQFPDPHRF
DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSL
LLRGIDHLPVRLDG

CYP107A2   Streptomyces rochei plasmid pSLA2-L
           NC_004808 complement(44847..46067)
           AB088224.1 complement(44847..46067)
           64% to 107A1
           note="ORF26 (406 aa), lankamycin biosynthesis protein
           similar to M54983-1 Saccharopolyspora erythraea
           6-deoxyerythronolide B hydroxylase, EryF CYP107A1
MTTDAHTAVPSLDSDLFHIDQYEAYAALREREPVSKVSFIGREA
FLITRHAEAKAALGDLRLSNDFKKQPPGVELPTYHGIPEDVRPYFANNMGSNDPPAHT
RLRRLVSREFTARRVESMRTRVAQLAEHLLDGLAGERETDLVERFAYPLPITVISELL
GVEERYQGDFGRWSNEFLVIDADRVEQREHAARALVGFILELVDRRRADPGSDLLSAL
IHVHDEDEDRLSTDELASVVLILLIAGFETSVSLIAMATYLLLTHPGELAKVRADPSL
VPNAVDEVLRFLGPAEITTRGTLEPVEIGGVHIPAHSTVLIAGAAANRDPRRFPDPER
FDVTRDTGGHLSFGHGIHFCVGGPLARLEGEIALRALLNRFPGLDLAIPAEQVRWRRS
FLRGIESLPVRLGR

107B Subfamily

CYP107B1    Saccharopolyspora erythraea
            GenEMBL M83110 Swiss P33271 (405 amino acids) PIR B42606 (405 
            amino acids)
            Andersen J.F., Hutchinson C.R.
            Characterization of Saccharopolyspora erythraea cytochrome P-450 
            genes
            and enzymes, including 6-deoxyerythronolide B hydroxylase.
            J. Bacteriol. 174, 725-735 (1992)

CYP107B1    Saccharopolyspora erythraea NRRL23338
            SACE_5814, se: 6524921,6526138 (-) STRAND
MTTGEVPDLLAFDDAFAQDRHNRYARMREEPVQRIRTVNGLDAWLITRYEDVKQALLDPR
IAKDFGRTQQIIEKRLADAERRPGFSPDLGPHMLNTDPPDHTRLRKLVVKAFTARRVEGL
RPRIEQITDDLLDRLAGRSEVDLIDEFAFPLPITVISELMGVEDSRRDDFRSWTNVLVDG
SQPEAQAQASVAMVEYLTELIAKKRTEPGDDLLTALLEAVEDGDRLSEGELIAMVFLLLV
AGHETTVNLIGNCVLSLLGNPDQLAALRNDPSLLPGAIEETLRYESPVANGTFRHTAEAV
RFGDVVIPEGELVWVALGAANRDGERFEDPDRFDITRETTGHVAFGHGIHFCVGAALARL
EAQIAVGRLLERFPDLRMAASPDDLRWRFSVLMRGLEKLPVRPGA 

CYP107B2   Streptomyces sp.
           GenEMBL BD133548 
           58% to 107B1
3   LIAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDSPVGIATFRFSTE 182
183 ALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFGFGMHHC 344

107C Subfamily

CYP107C1    Streptomyces thermotolerans
            GenEMBL D30759 (3267bp complete sequence of CarA) 
            Arisawa,A., Kawamura,N., Takeda,K., Tsunekawa,N.,
            Okamura,K. and Okamoto,R.
            Cloning of a macrolide antibiotic biosynthesis gene acyA, which
            encodes 3-O-acyltransferase, from Streptomyces thermotolerans and 
            its use for direct fermentative production of a hybrid macrolide.
            Appl. Environ. Microbiol. 60, 2657-2660 (1994)

            Arisawa,A., Tsunekawa,N., Okamura,K. and Okamoto,R.
            Nucleotide sequence analysis of carbomycin biosynthetic genes
            including macrolide antibiotics 3-O-acyltransferase gene from
            Streptomyces thermotolerans.
            unpublished (1994)

CYP107C1    Streptomyces thermotolerans
            GenEMBL M80346 (2393bp C-terminal fragment of CarA)
            Schoner,B.E., Geistlich,M., Rosteck,P., Rao.R.N., Seno,E.,
            Reynolds,P., Cox,K., Burgett,S. and Hershberger,C.L. 
            Sequence similarity between macrolide resistance determinants and
            ATP binding transport proteins.
            Gene 115, 93-96 (1992)
            Note: P450 fragment called carX. is equivalent to C-terminal of CarA.

107D Subfamily

CYP107D1    Streptomyces antibioticus
            GenEMBL L37200 (1400bp)
            Rodriguez,A.M., Olano,C., Mendez,C., Hutchinson,C.R. and 
            Salas,J.A.
            A cytochrome P450-like gene possibly involved in oleandomycin 
            biosynthesis by Streptomycese antibioticus.
            unpublished (1994)

107E Subfamily

CYP107E1    Micromosospora griseorubida
            GenEMBL D16098 (2168bp)
            Inouye,M., Takada,Y., Muto,N., Horinouchi,S. and Beppu,T.
            Cloning and nucleotide sequences of a gene governing mycinamicinIV
            hydroxylation.
            unpublished (1993)

CYP107E2    Saccharopolyspora erythraea NRRL23338
            SACE_1426, se: 1577490,1578686 (+) STRAND
            58% to 107E1, 56% to 107N1
MPEPRPYPFSAAERLNLDPFYARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFS
RAAVLEKDEPRMRPGITGGGILSMDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLV
DRMIEHGSPADLVEEFALPLPITVICELLGVPYEDRDDFREWSDAFLSTTKLTPEQVVDY
MDRMFGYMAGLIAKRRVDPQDDLMSALIEARDEHDKLTEQEMVQLAAGILVAGHETTATQ
IPNFVYVLLTHPDQLEGLLADLDGLPRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVR
AGEPVLVSASSANRDEAVFDDPDRLDLTRENNAHIGFGHGPHHCLGAQLARLELQVGLRT
LLTRLPGLRFAGGEDDVVWKEGMLVRGPSKLEVAWQSE

CYP107E3    Salinispora tropica (marine actinomycete)
            Strop_2770 	complement(3139855..3141042)
            59% TO CYP107E2      Saccharopolyspora erythraea
            52% to CYP107E1 D16098 Micromosospora griseorubida
MTIDQEIRKYPFCESPGIGIDPTYGLLRSTEPLARVQLPYGEVSWLATRYEDVKTVLTDP
RFSRAAAQGKDQPRTREEMTYEGIIGLDPPDHTRLRKLAGKALTARRVNAIRADAQRIAN
EYVDEMIAKGSPGDLVELFALPYPVTVICELLGVPFEDRAQFRIWTEGLTSTSEQLMVYA
EQLFGYMGKLVAQRREEPTDDLLGALVKARDEGDRLTEQELLSIAGVGLLLTGVETVSTH
IPNFVYALLTHPELMAQLRADRSLVPAAVEELLRMIPLNPAAMFPRYAVEDVTLSGITVR
AGEPVLVSLPGANRDPEVFENPETFDFTREQNPHVAFGHGPHHCLGAQLARMELQVALHT
VLDRFPDLSLADGDEGVSWKSGLLVRGPSRLLVAW

CYP107E4    Actinoplanes sp. ATCC 53771
            GenEMBL FJ754024
            Prior,J.E., Shokati,T., Christians,U. and Gill,R.T.
            Identification and characterization of a bacterial cytochrome P450
            for the metabolism of diclofenac
            61% to CYP107E2

CYP107E5   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_8067 
           57% to CYP107E2 Saccharopolyspora erythraea NRRL23338

CYP107E6    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE8636 56% to CYP107E2

CYP107E7    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY603 56% to CYP107E2

CYP107E8    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6929 64% to CYP107E2

107F Subfamily

CYP107F1    Streptomyces griseus
            GenEMBL D45916 (2787bp) AB018074 CDS 341-1561
            Ueda,K. and Horinouchi,S.
            Cloning and Nucleotide Sequence of a Gene Involved in Redbrown
            Pigment Biosynthesis in S. griseus
            Unpublished (1995)

CYP107F1    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR6619
            One amino acid difference with D45916 sequence

CYP107F2   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV1171 55% to 107F1 
           this subfamily is on the outskirts of CYP107

107G Subfamily

CYP107G1   Streptomyces hygroscopicus
           GenEMBL X86780 (107379bp)
           complement (91764-92978)
           rapN

107H Subfamily

CYP107H1  Bacillus subtilis
          GenEMBL U51868 (10153bp) Z99119, AF008220
          coding region 7164-8351
          pimelic acid biosynthesis
          gene name bioI

107J Subfamily

CYP107J1  Bacillus subtilis
          GenEMBL Y11043 U93876, Z99117
          Belitsky, B. R., M. C. Gustafsson, A. L. Sonenshein, and C. Von
          Wachenfeldt. 
          An lrp-like gene of Bacillus subtilis involved in
          branched-chain amino acid transport. J Bacteriol. 179, 5448-57 
          (1997).
          gene name cypA 42.6% identical to 107B1
          also called yrdE

CYP107J2  Bacillus anthracis str. Ames 
           GenPept AAP26475
           58% to 107J1 cypA of Bacillus subtilis
  1 MAMKNKVGIR IEDGINLASA QFKEDAYEIY KESRKVQPVL FVNKTELGAE WLITRYEDAL
 61 PLLKDNRLKK DPANVFSQDT LNVFLTVDNS DYLTTHMLNS DPPNHNRLRS LVQKVFTPKM
121 IAQLEGRIQD IADDLLNEVE RKGSLNLVDD YSFPLPIIVI SEMLGIPKED QAKFRIWSHA
181 VIAYPETPEE IKETEKQLSE FITYLQYLVD MKRKEPKEDL VSALILAESE GHKLSARELY
241 SMIMLLIVAG HETTVNLITN TVLALLENPN QLQLLKENPK LIDAAIEEGL RYYSPVEVTT
301 SRWADEPFQI HDQTIEKGDM VVIALAAANR DETVFENPEV FDITRENNRH IAFGHGSHFC
361 LGAPLARLEA KIAITTLFER MPELQIKGNR EDIKWQGNYL MRSLEELPLT F

CYP107J3   Bacillus cereus ATCC 14579
           GenPept AAP09568            
           59% to 107J1 cypA Y11043 Bacillus subtilis
  1 MKNKVGLSIE DGINLASAQF KEDAYEIYKE SRKKQPILFV NQVEIGKEWL ITRYEDALPL
 61 LKDNRLKKDW TNVFSQDIKN MYLSVDNSDH LTTHMLNSDP PNHSRLRSLV QKAFTPKMIA
121 QLDGRIQRIA DDLISDIERK GTLNLVDDYS FPLPIIVISE MLGIPKEDQA KFRIWSHAVI
181 ASPETPEEIK ETEKQLSEFI TYLQYLVDIK RKEPKEDLVS ALILAESEGH KLSARELYSM
241 IMLLIVAGHE TTVNLITNTV LALLENPNQL QLLKDNPKLI DSAIEEGLRY YSPVEVTTAR
301 WAAEPFQIHH QTIQKGDMVI IALASANRDE TVFENPEIFD ITRENNRHIA FGHGSHFCLG
361 APLARLEAKI AITTLFNRMP ELQIKGNREE IKWQGNYLMR SLEELPLTF

CYP107J4P  Bacillus cereus ATCC 14579
           GenPept AAP09593                 
           46% to CYP107J3 in same genomic region
           47% to CYP107Y1 SAV2377 AP005030 Streptomyces avermitilis
           50% to 107H1
  1 MKEPQLQQHL EKFIQYIEAL VNEKRLNPDA DLISELVQTK EQEDKLSNNE LLSTIWLLII
 61 AGHETTVNLI SNGLLALLQH PEQMNLIREN PSLIPSAVDE LLRHSGPVMF ISRLASEDMT
121 IHGKRIPKGD LVLLSLTAAN IDPQKFTYPE TLNISREENN HLAFGAGIHH CLGAPLARLE
181 GQIALGTLLQ RLPNLRLAIK PDQLNYNHSK IRSLVNLPVV F

CYP107K1   Bacillus subtilis
           GenEMBL AL009126 Z99113 comp(76702-77832)
           polyketide hydroxylase pksS
           just over 41% identical to CYP107J1

CYP107L1   Streptomyces venezuelae 
           GenEMBL AF087022
           GenEMBL AF079139 CDS 122..1372
           pikC gene
           function="catalyzes the hydroxylation of YC-17 into
           methymycin and neomethymycin and narbomycin into
           pikromycin"
           51% to 107B1 47% to 107A1 44% to AF254925 42% to 107J1 
           41% to AL049754 new CYP107 subfamily

CYP107L2   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV1987 60% to 107L1 from Streptomyces venezuelae

CYP107L3    Streptomyces tubercidicus strain I-1529
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name CypLA
            60% to CYP107L1 91% to 107L4

CYP107L4    Streptomyces tubercidicus strain R-922
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name CypLC
            61% to CYP107L1 91% to 107L3

CYP107L5   Streptomyces sp.
           GenEMBL BD133547 
           68% to 107L2 
3 LIAGHETTVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAE 182
183 PLEIGGTVIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGFGTHRC 344

CYP107L6   Streptomyces sp.
           GenEMBL BD133544 
           72% to 107L2
MGHEHVIDLGEYGPGFTENPHPVYAELRARGPVHRVRLPKHDAHHEAWLVVGYEEARAAL
ADPRLSKDGSTIGVTFLDEELIGKYLLIADPPQHTRLRGLIAREFTGRRVERLRPRVQEI
TDSLLDEMLPRGRADLVESFAYPLPLTVICELLGVPEIDRAAFRKLSTEAVAPTSGESEY
AAFVQLAAYLEELVEEKRCAPPADDLLSALIRTTDEDGDRLSPAELRGMAFILLIAGHET
TVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAEPLEIGGT
VIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGHGIHFCLGAPLARLEARVA
LRALLERCPGLTPDGAPGEWLPGMLIRGVRSLPVRW*

CYP107L7P   Streptomyces narbonensis
            GenEMBL AF521878  13901..14661
            desosamine biosynthetic gene cluster
            91% to 107L1
            gene= nbmL
            note= frameshift and deleltion generates premature 
            stop codon and truncated protein"
MSRTHQGTTASRPVLDLAALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDTARAVLADPRFSKDWRNSATPPTEAEAALSHNMLESDPRCGPT
(deletion)
ALRADLTLLDGAVEEMLRYGGPVESATYRFPVEPVDLDGTVLPAGETVLVVLAD
AHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCTGAPLARMEARIAVRALLERCPDLALD
VSPGELFWYPNPMIRGLESLPIRWRSGREAGRRVPVEPACRP*

CYP107L8   Streptomyces sp. HK803
           GenEMBL AY354515 complement(72672..73871)
           Gene = plmS2
           56% to CYP107L6
MVTVDLSAYGPGFFTDPYPYYARLREAGPVHEIVLADGDRFWLI
VGYDEARAALADPRLAKSLDPPSEDERHVLITDPPDHTRLRRLVSREFTARRVEAMRP
RVQEITDGLLDEMVAGRRRADLVPSLGSPLPITVLCELLGVPLADREDFRGWTERVLV
PAEPDTIAWWKSRGFAQAGMALTDYLKNMIEDKRRSTPTGDLISSLLRTTAEDNDRLS
AAELHSMVFILIVAGHETTANLITNGVRALLAHPEQLAALRTDPEGLIDQAVEEMLRY
DGPVETSTKRFTLEAVRYGATKIPPGETLLVSIAATGRDPAQFERPDTFDIHRGTTGT
RSGHVAFGHGIHFCLGAGLARMESRVAILTLLRRCPDLALDIDPAGLDWLPGIRVRGV
RSLPVRW

CYP107L9   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           62% to 107L6 before frameshift at C-term
           clone name SP0854

CYP107L10   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1278
            59% to CYP107L1

CYP107L11   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1279
            60% to CYP107L1

CYP107M1   Actinomadura hibisca 
           GenEMBL D87924CDS complement(6299..7534)
           45% to AF127374 CDS 3226..4458 44% to AF254925 
           45% to 107D1 44% to 107G1, 107E1 new subfamily in 107

CYP107N1   Streptomyces lavendulae 
           GenEMBL AF127374 CDS 3226..4458
           50% to 107D1 52% to AF254925 47% to 107E1 new subfamily in 107

CYP107N3   Streptomyces peucetis
           AJ605544.1
           SP0881 
           91% to 107N1 
VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW
LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT
PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT
WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE
LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV
DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP
HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*

CYP107P1   Streptomyces coelicolor cosmid H10 
           GenEMBL AL049754 CDS complement(10413..11648)
           41% to AF087022 40% to 107B1 40% tp 107G1 
           40% to 107D1 new subfamily in 107
           cloned and expressed by David Lamb and Steve Kelly

CYP107P2   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV4539 86% to 107P1 from Streptomyces coelicolor

CYP107P3   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           78% to 107P2 missing 156 aa at N-term
           C-term may be frameshifted
           clone name SP0887

CYP107P4   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9576 
           75% to CYP107P1 Streptomyces coelicolor

CYP107P5    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE4373 66% to CYP107P1

CYP107P6    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY4628 72% to CYP107P1

CYP107P7    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR3408
            72% to CYP107P2

CYP107Q1   Amycolatopsis mediterranei 
           GeEMBL AF040571 CDS complement(781..>2316)
           66% to AF040570 comp(68704..69969) 43% to 107C1 
           41% to 107B1 40% to 107A1 new subfamily in 107

CYP107Q2   Amycolatopsis mediterranei 
           GenEMBL AF040570 CDS comp (68704..69969)
           66% to AF040571 complement(781..>2316) new subfamily in 107

CYP107R1   Streptomyces maritimus 
           GenEMBL AF254925 CDS comp (18384..19589) 
           gene="encR" 
           53% to AF127374 CDS 3226..4458 49% to 107E1 new subfamily in 107
MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGE
AWLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVA
GVFTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDD
REQLRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDR
EEGLLRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVE
ELLRFIPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDID
RSPNPHVAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVR
GPKTLPVKW

CYP107S1   Pseudomonas aeruginosa
           NZ_AABQ07000001
           NC_002516 3741011..3742267
           locus_tag = PA3331
           47% to 107B1

CYP107T1   Streptomyces coelicolor  
           StH63 [Full Sequence] Sanger cosmid 
           51% to CYP107L1 CDS 16028-17233
           cloned and expressed by David Lamb and Steve Kelly

CYP107U1   Streptomyces coelicolor 
           StE41 [Full Sequence] Sanger cosmid 
           comp(7438-8739) 44% to CYP107B1 
           cloned and expressed by David Lamb and Steve Kelly

CYP107U2   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV3536 85% to 107U1 from Streptomyces coelicolor

CYP107U3   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           84% to 107U1 missing 90 aa at N-term
           clone name SP0819

CYP107U4   Streptomyces scabies
           SCAB54411
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           90% to 107U1 Streptomyces coelicolor

CYP107U5   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_8392 
           80% to CYP107U2 Streptomyces avermitilis

CYP107U6    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE3655 80% to CYP107U4

CYP107U7    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY3619 82% to CYP107U4

CYP107U8    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR4436
            83% to CYP107U4

CYP107V1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV3519 low 40% range with some 107 subfamilies

CYP107W1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2894_olmB low 40% to 107 subfamilies

CYP107X1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV6249 49% to 107L1 from Streptomyces venezuelae

CYP107X2    Saccharopolyspora erythraea NRRL23338
            SACE_1158, se:1279482,1280657 (-) STRAND
            57% to 107X1
MRPVEIDDEFVTCPHAAYARLREQGPVHRAVAPDGSRVWLVTRYDDVRAALADSRLSLDK
AHATDGYRGLSLPPALDANLLNMDAPEHTRLRRTVTRAFTAHRTELLRPRVQEIADELLA
AVAGQERAELMSAFAGPLPITVICELLGVDARDRPDFRAWTDEMLAPSTPDRARDSLRSL
YAFLVDLIARKRAEPGADMPSTLVGLRDEDGSLTEDELTSTAFLVLFAGYENTVNLIGNG
LAALLARPAQLAAVRSDRGLLPSTVEELLRFDPPPQLSIRRFPKEDLEIGGVRIPAGDTV
LLSLVSAHHDPARFTSPGELIPDRADNAHLAFGHGPHFCIGAPLARMEAEVAFSTVLTRF
PALSLAVDPAELRWRPSFRNRGLRELPVRLS

CYP107X3   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_2046 
           67% to CYP107X1 Streptomyces avermitilis

CYP107X4    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY8268 66% to CYP107X1

CYP107Y1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2377 50% to 107L1 from Streptomyces venezuelae

CYP107Z1    Streptomyces rimosus ssp. paromyceticus strain R-2374 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema11
            96% to CYP107Z2v1

CYP107Z2v1  Streptomyces albofaciens strain C-0083
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema8
            96% to 107Z2v2 and CYP107Z1

CYP107Z2v2  Streptomyces rimosus ssp. paromyceticus strain BOEH-4355
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema3
            96% to CYP107Z2v1 95% to CYP107Z1

CYP107Z3    Streptomyces sp. strain IHS-0435
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema7
            76% to 107Z12

CYP107Z4    Streptomyces lydicus strain NRAB-0114 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema16
            82% to 107Z12

CYP107Z5V1  Streptomyces lydicus strain NRRL-2433 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema15
            97% to 107Z5v3

CYP107Z5v2  Streptomyces chattanoogensis DSM-40241 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema6
            1 aa diff to CYP107Z5v3

CYP107Z5v3  Streptomyces lydicus strain R-401
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema4
            100% to S. kasugaensis strain A/96

CYP107Z5v3  Streptomyces kasugaensis strain A/96
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema10
            100% to S. lydicus strain R-401

CYP107Z6    Streptomyces sp. strain I-1525 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema5
            85% to CYP107Z8

CYP107Z7    Streptomyces tubercidicus strain DSM-40261 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema17
            90% to CYP107Z8

CYP107Z8    Streptomyces platensis strain Tu-3077 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema13
            89% to CYP107Z9

CYP107Z9    Streptomyces tubercidicus strain NRAA-7027 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema12
            89% to CYP107Z8

CYP107Z10   Streptomyces tubercidicus strain I-1529 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema2
            90% to CYP107Z11

CYP107Z10   Streptomyces platensis strain I-1548
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema14
            100% to S. tubercidicus strain I-1529

CYP107Z11   Streptomyces platensis strain NRAA-7479 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema9
            92% to 107Z12

CYP107Z12   Streptomyces tubercidicus strain R-922 
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name Ema1
            92% to CYP107Z11

CYP107Z13   Streptomyces ahygroscopicus
            No accession number
            Li Mei
            Submitted to nomenclature committee Nov. 25, 2008
            83% to CYP107Z3

CYP107AA1   Mycobacterium smegmatis
            MSMEG3142 TIGR 
            RubU (pksS)
            45% to 107B1 43% to CYP107AB1P
            41% to CYP105S2 Mycobacterium vanbaalenii
MTPYSRRDRNH
MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLT 
DPRIGKDGAAASALFPPGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAF 
TAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELL 
GVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPAD 
DVLSSLVHRRDGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRN 
PEQLRAVRADRSLLPRAVEEALRFESPLNTATVRYTSAPVTVGDVEIPSG 
ELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM 
EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIAS 
TMREWSGSLPSSGEADSSFAH

CYP107AB1P    Mycobacterium smegmatis
              45% to CYP107B1
              43% to CYP107AA1
MILDEQFAQDPEGLYRMLRSEAPVCEVELIGGVRGWLVTRYADVMALLKD 
PRVSKDHTSALPRLAPDRVRPYISPQLHNHMLNLDPPEHTRLRRLVVQAF 
TPKALARMQPVIDAIADELLDDIDLRSGDEPIDLMADYAEPLPIQVIAEL 
LGVAVEYA*PFRAAVTPLLMSVTVEEKAESGRATIEILNAVIDEKIREPG 
EDLLSGMIGASVDGHGLTRDELMAMCFLLITAGYETTVNLIGNGTLALID 
NPSQLEKVRENPDLTAGAVEEILRFDGPVNIATWRYATADIDVDGVVIPA 
NEQIFLSLLSANRDTGRFENADRFDIERNTRGHIAFGHGIHYCLGAPLAR 
MEGVTAIGRIVQRYDSITLDPTAELRYHNGTLMHGLKSLPVRLTRVPQPRP

CYP107AC1   Streptomyces atroolivaceus
            GenEMBL AF484556 60948..62147
            leinamycin biosynthetic gene cluster
            48% to 107N1
            gene = LnmA
MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGE
GWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSK
AFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDR
GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD
DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEEL
LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITRE
KNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGP
QRLPIAW

CYP107AD1   Streptomyces hygroscopicus
            GenEMBL AF521896 4248..5489
            ansamycin biosynthesis gene cluster
            43% to 107X1
            gene = gdnH
MSGRHFEQGERGTAMADTPEEELRILDPQSVAQELRKHGPPRQI
TMHGTTAWLVSRYEEVRDCLGHPGMSPAAAYAASQGQTNPVSGLFEDTVAGTNPPQHT
RLRRLLAKAFTVRRVESLRPRVQEITDTLLDRIAVDGRADLVSALAIPLPMQVICELL
GVPIADRTEFHQWADLMLTPPLDPDTAARSQDASAKLWTYMEDLAEARRKAPEDDLIS
DLMSAHEDDRLSHREVVATARMMLIAGYELTGSFISNAVFSLLSQPDQMELLRKDPEL
AGRGLEELLRHAGPGILIVRFANEDVEIGSVSIRAGDQVLLDMDAAHSDPAHFTDGER
LDLTRDSAVHLQFGHGIHYCIGAPLARVEGQIALESLVRRFPGLRLSVPAAEISHSKN
PFIRSLTALPVEFEAQQPVAG

CYP107AE1   Streptomyces sp.
            GenEMBL BD133545 
            50% to 107X1
VILLKSLAANGLTASSCFTVSPLPIRSASPSIAFLTSSSERDSGVRNDRPSDAQPAIARF
RFPTPPHPRNPTQPHPTPPRPSPTDDPLQAPTFFADPYPTYARLRDTAPVLKVPTGSGGG
GRHSYVVTGYAEAREAFTDPRLSKDTASFFAGRPSQRDLHPAVSRNMLATDPPQHARLRA
LVTKAFTTGAVARLRPYISSLVDELLDTWPTHGTVDLIADLAVPLPVTVICELLGVPDSD
RASVRTWSSDLFAAGDPQRIDAASHAVGDYMTALVAAKRTAPGDSLLDDLIAVRDGQDHL
SEDELVSLAVLLLVAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDS
PVGIATFRFSTEALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFG
HGIHRCLGAPLARAEAELALHAVITRYPQAALATPPETLPWRHTRLTRGLASLPITLRDH
PK*

CYP107AE2   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY639 66% to CYP107AE1

CYP107AE3   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR420
            69% to CYP107AE2

CYP107AF1   Streptomyces collinus DSM2012
            GenEMBL AF293355 24259..25518
            Gene = rubU
            rubrinomycin gene cluster
            52% to 107B1
MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPN
GLRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPH
VLSVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLME
ALAFPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEA
KRNEPADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHP
EVREQLAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGA
AGRDPDRYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLR
LAADPDELSWRSSLMMRGLEELPVFTA

CYP107AG1   Streptomyces atroolivaceus
            GenEMBL AF484556 complement(120436..121638)
            Gene = LnmZ
            leinamycin biosynthetic gene cluster
            49% to 107E1
MSTEVETEKPAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLP
FGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRT
LVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVP
EDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIEA
RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIPAA
VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV
IDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEWKADMIIRA
PRVMHVEW

CYP107AH1  Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           50% to 107L6 missing about 42 aa at N-term
           clone name SP0749

CYP107AJ1  Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           52% to 107B1 frameshifted C-term
           clone name SP0908

CYP107AK1  Streptomyces scabies
           SCAB79691
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           48% to 107AF1, 47% to 107B1

CYP107AL1  Streptomyces scabies
           SCAB63301
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           45% to 107AC1, 45% to 107N1, 45% to 107M1

CYP107AM1  Streptomyces scabies
           SCAB44031
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           41% to 107AC1, 42% to 107E1

CYP107AM2  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7397 
           68% to CYP107AM1 Streptomyces scabies SCAB44031

CYP107AN1   Bradyrhizobium japonicum USDA 110
            GenPept BAC51802                 
            NC_004463 complete genome complement(7193424..7194725)
            41% to 133B1v1 45% to 107L1
            formerly CYP107AA1, but this name was also given to 
            an M. smegmatis sequence so one had to be changed.  
  1 MVTPGSGAAI GVFVSCGNRF EVTMNEQAQP AGGDPLFNPL SPDFIRNPYP HYDRLRAIDP
 61 IHVTPFGQFV ASRHADVSLV MRDKRFGKDF VERSKRRYSE KIMDEPVFRS MSHWMLQADP
121 PDHTRLRGLV VKAFTARRVE DMRPRIQEIV DEAIDAVIDR GHMDLIEDFA FRLPVTIICD
181 MLGIPEDHRE VFYKSSRDGG RLLDPVPLTP EEIAKGNAGN MMAQMYFQQL FELRRRNPAD
241 DLTTQLVQAE EDGNKLTNEE LTANIILLFG AGHETTVNLI GNGLLALHRN PDQLALLKAR
301 PELMVNAIEE FLRYDSSVQM TGRVTLEDID DLGGRKIPKG ETVLCLLGSA NRDPAVYPDR
361 PDRLDVTRPN VKPLSFGGGI HFCLGAQLAR IEAEIAIATL LRRLPDLRID DVENPEWRPT
421 FVLRGLKSLP ASW

CYP107AP1   Streptomyces rochei plasmid pSLA2-L
            NC_004808 Links 87725..88939
            49% to 107A1 
            note="ORF37 lankamycin biosynthesis protein
            formerly CYP107AB1 but that name was already assigned
            to an M. smegmatis seq. (my error)
MNQPQLPEIPALNSELFHTDQYATYREILEQRPVTRVRFYDGSL
VWLVNRHEDVRAALTDPRLSNDPMKQSDIDLSAATGIPADLIEYFQRNMFRSDEPDHG
RLRKLVTREFTVRRINALRPRIRQIADDLLEKFAATGGGDLVEALARPLPLTVMCELL
GVPEEDRADFQTWSQHIVESSPEFAERNAVSYRSLFECVRSLIRRRRDEPGDDLLSAL
VDLRDVADRLSENELISTVFLLLVAGIETTVNVLGTGTFLLLTHPGELARLRADGALL
GPAVEEMLRYMAPIEITSRHTLEPVEIGGVSIDAQSTVLINLAAANRDPARFEDPQSF
RVDRNDGGHLTFGHGIHYCLGAALARAEAEVTFEALLERFPDLRLAASASDLTWRHAF
MRGPVELPVSWG

CYP107AQ1   Saccharopolyspora erythraea NRRL23338
            SACE_0125, se:152305,153462 (-) STRAND
            50% to CYP107P1
MFDTADPAFVADPYPCFAELRRRGEVHRHPGLGMAVAVSHAAASEVLRHRGLGRIWVDAQ
PAADFPAFNLLHRTSLLETEGAEHTRLRRSISAAFARGHVERVRPWVAGLADALVGGLVE
RGGGDVVEEVAAPLPVQVIAELLGVPESDRNLLRPWSNAIVKMYEPGLPERRRAAAESAA
AEFAEYMRALADRRRSAPADDMVSDLVAAEELSADEVVGTAVLLLMAGHEASVNLVANGV
LALLRHPGQWRRLVDDPGLVPTAVEELIRYDSPLQLFERTAVEDVVVAGHRVAAGSKIAA
LLGAAARDPEVFESPDVLDVGRQPNPHLGFGAGIHYCLGAPLARVEAAAALSALVRLAPR
LEQAGEPVRRPEFVIRGLRELPVSV

CYP107AR1   Saccharopolyspora erythraea NRRL23338
            SACE_0651, se:714930,716198 (-) STRAND
            44% to CYP107Y1
VQPDQSPTPRPESRHSPAAACPHAAVHREERPGGLVTWQISAFSEARAALGDSRFSKDPR
RLGEALRAGGRSMFAEYGDNLLDNLLNSDPPDHTRLRRLVGKAFSPATIERLGPTTQRLA
DELVASMLPAGRADLLAQFAYPFAFGVIARVLGLPPDSYRIFQRWTESMTAPREQGTDRM
VAARHLCEHVTELVRRSREWLASAPAETLLDELVSARDDGDRLSENELVATVLLLIIAGH
ETTVNLIGNGVHALLQHPGQLALLRDHPDLIDGAVEELLRFQPPISKTTLRVTTTDVEVA
GTEIPAGSIVNVLVPAANRDQRQFPDADRLDITRPPSAHMSFGHGIHYCIGAPLARMEGR
IAIGALLRGLPGLRLAEPAAEIPWRASNILRGLQRLPVRFDSAGADDEVRDRRHAGAARV
HA

CYP107AS1   Saccharopolyspora erythraea NRRL23338
            SACE_2922, se: 3203418,3204656 (+) STRAND, 
            48% to CYP107D1
MTESIQRDADSQEAACPHARAYPFGDPGALDLDPDYARVRDEEPLTRIRMPYGEQGWLVT
RYDDVRTVLADPRFSRSEVLKRDVPRPTPQQVERPGTLVTTDPPEHGRLRRLVAGAFTHR
RAESMRPRIRGVVDELVDEMLAGDKPADLVAAVSMPLPVNVICELLGVPREDRHVFHSGA
VLSDYTVPADEREATFKSLADYLAVLIAERRARPEGPGDDVLGALISARDTDGDRLSEDE
LIELWVDILVAGYASIMSVTPDMVVTLLTERDRWDGLVADPGGVPDAVEEMLRVMPTIIE
SGHSRVATEDVEIAGGTVRAGEAVLPCLPAANRDPAVFDAAEEMRLDRDAGKHIAFGFGP
HYCLGASLARVQLQSVLTALVRKVPTLDLVEAVREDSTRVAAAVQGQLLVTW 

CYP107AT1   Saccharopolyspora erythraea NRRL23338
            SACE_4142, se: 4611465,4612715 (-) STRAND
            56% to CYP107AT2, 47% to CYP107AU1
MSVGDIDTPSGEFDFAANLLPFDPLDPAFQADPYPFFRLVRETAPALCTQPGMWVVTGFR
ECSAVLRNPKFGHGDGRLVASQITHDAEGNVVRPFVFMDPPDHTRIRSLVTKAFSARMVE
RLRPTAERLVGELLAAAMSGPADEPVDLMAELAFALPSNLISELLGMPPQDKPLFEQWSS
ALGRGLDPDFMLSPEEMQRRDQARTEFDGYFAELARRRRAEPADDLVSALVAVEEDGRNL
SMSELVSTCRLLLSAGYLSTAHLIGNGVNALLRHPEQFEWFRAHPDQVAGVVEELLRYDS
PVQTAGMRTALQDTEIGDQPVSAGEGAMLLVGAANRDPAAFPDPDRLDVSRKPERNLGFG
IGAHFCVGAPLARLTTQVALTALAGLRVELATDDAPRINNLVLRGFAELPVFLRAA 

CYP107AT2   Saccharopolyspora erythraea NRRL23338
            SACE_4144, se: 4614537,4615769 (-) STRAND
            56% to CYP107AT1, 47% to CYP107AU1
MSTTEGAPPVDSNVVRQLLLFDPFDPEFRADPHRVYREIRESGPVTATPGGLWLVSGHRQ
VSAVLRDQAFGWGEAELAAGHFTTDDEGNTVRPLTFADPPEHTRIRSLVTSAFSARIVER
LRPRAQELARESLAAALAGGGSADVIQQVAYPLTGRLLCELLGVDPEYQERFRAWAEAMG
RGLDPDFMQSPDQLARREEARAHFHEYFAELAARRRAEPGDDLVSALVAVEQEGDRLTAT
ELVVTCTLLLSAGYATTVHLIGNGMLALLENPDQLAWLRANPGRVGDAVEEVLRFDGPIQ
LVSRVALRDTEVDGHAVAAGSPVLLLLAAANRDPAVFDDPDRLDVSRKPGRNLGFGVGIH
FCLGAPLARLTAQAALSLLVEHELVLDGPRPAPTGSLVLRGLAELPLRSA

CYP107AU1   Saccharopolyspora erythraea NRRL23338
            SACE_5309, se: 5939205,5940431 (+) STRAND
            47% to CYP107AT1, 47% to CYP107AT2
MTAGTNNAGRLGALAEAVLGYNPVDPEYHANAHEHHRRMAERGPIFRTPGGMWTAVSHAA
CSAVLRDDRFGHDPGSAAQNLFDSTQRPSVAQRSFEFMDGPDHSRLRRLVNRAFTARRVE
RLRPAVRTLADQLLTDVSGRIDVLADFILPLAMTTIVDMLGAPTEDNHLFRAWAEPIVRG
LDPDFLLSSSELAAREQANAEFAEYFDRLVALRRAEPKDDLISALIAVEDDGVVLSGNEL
ISMCLLLLAAGHESIMHLVGNGTVALLRDEDQLEHFRGHPGEVTNAVNELLRYDPPVVLL
VRTALADAEVLGNRVRRGEIVWLQIGAANRDPAVFPDPDRLDLTRDTGGSLAFGLGIHFC
IGASLARLEAAAALSALLHRDVALASEQLVHQKNVVIRGYEEVPVVLR

CYP107AV1   Saccharopolyspora erythraea NRRL23338
            SACE_5939, se: 6665300,6666601 (+) STRAND
            44% to 107L1, 43% to 107AT2, 41% to 107AN1
MTTAEPAETGSLAELNLGMRLVLHGAVTWSIARLGDPVARLLHSPWRRDPYPIYRQLRAR
GPLVRSRLGVWAASTYEVCDAVLRDRRFGVRTSDGSYGDPTAAAVGLQLSLLELDPPDHT
RLRKLAAPAFRPRKLENYRQRIEDTAHELLDRALAKGEFDLIRDFATPLPIRVICELLGL
PELGAERLAVHGAALSGALDGIRSIRHLRRMRASTLELNELFGDLIEQRRRQPGEDIVSD
LVTALDQDRLDSTELVQMCDLLLVAGFETTVNLIGNGVLALLERPDQWRLLCDDPDQAVG
VVEETLRWDPPVQTTMRVAHEPVEVAGRLLPRNSAVLPMLGAAGRDPAVHFAPDRFDITR
GTRGDHLAFSSGIHYCLGAPLARLESEIAFRCLATRVPELRRSGALVRRPTSVIHGLSAL
PVAASKATAGGRR

CYP107AW1    Salinispora tropica (marine actinomycete)
             Strop_2290 complement(2583447..2584649)
             49% to CYP107B1 M83110 Saccharopolyspora erythraea
MESVTSTSAPPPVPYIADPYPALARIRANGPVSILHSDEGIPMWVIARYRNVRAALADPR
FGQDARRAQTLADNRVAGVTLGGDVIHMLNSDPPDHTRLRHLVQGAFTARRVAAMRPLVE
RITTSLLDGVGGRQTVDLVQDFAFPLPMLVICELLGFPAEERDAYRSWSTAILTHNDDPA
AFATALRDMTDYIEVQLRHRRARPGEDLLTELLAARDAGQLTDDEIVGMVFLLLIGGHET
TVNLLGTATLALVRNPDQHRWLLANPHALSEAIDEFLRYESPVAMATLRFTTAPVTVDDV
VIPAGELVLVSLGGANRDPDRFPDADRLILDRRDTGHLAFGHGLHRCLGAFLGKLEGEVA
LGALLGRYPGLTLAAEVRQLRWRDTIMLRGLESLPVSLHG

CYP107AX1    Salinispora tropica (marine actinomycete)
             Strop_2367 	2663162..2664352
             47% to CYP107X1 SAV6249 AP005046 Streptomyces avermitilis
MTSRPTAVFDQCLLRDPHSRYNALRDQAPVHHVLTPDGAPAWLVTRYNDVRAAFTDPRLS
VDKRFSGTDGEHGSSLPPELDAHLLNRDPPDHTRLRRLAAAACTPRRVADLHPAVERIVS
TLLDGLAGHDRAELIGSLASPLPLQVMHELLGLPTQANIDFRTWTNTLLSADANQPAQSR
AAMANMRRFLIEQLAHKRAQPGDDLLTGLLAAREDDDRLTDDELVAMVFLLMFAGYDNTA
ALIGTVTHALLTNAELHEAVRGGSLALDELIDEVLRWNPAFPLAVRRFAREPITIAGQTI
PAGDRIWLCLASANRDPAQFTQPDELGIIGLRRSHLSFGHGIHYCLGAPLARLQTTIAVT
SLLNRFPEMRLAVPAHDIRWRESFRLRGLIALPVYL

CYP107AY1    Salinispora tropica (marine actinomycete)
             Strop_4427 	complement(5021489..5022637)
             49% to CYP107X1 SAV6249 AP005046 Streptomyces avermitilis
MSQDPTMRAELAPIPRSGARLGQEYDQLRNAGDVHQVLLPDSSLAWLVTNPKLVSRALTD
PRLALNRRHSRGSWSGFALPPALDANLLNLDAPDHTRLRRLVGPAFSPQRVSALRPRIRR
TAEHLLDTLVATSGPVDLVTGYCTPLSVQVIADLMGVPEAGRADLRTWTDTMLTSYPPDR
DAIRQAVVELHGYVVDLIDTKRQQPGDDLLSALVTIEQDGDRLTRDELTSLAFLILFAGY
ENTANLIASTVLRLLDHGGLRGVQLPEAIEETLRLEPPAPAAVRRFPTEEMTIGGATIPA
GDIVLLSIAAATRGTAGNAARLAFGNGPHFCLGAALARVEAEEALTVLARRLPDLALALP
VAQVRWRPTFRTHGPAELLVTW

CYP107AZ1    Roseiflexus sp. RS-1, complete genome.
             GenEMBL CP000686 REGION: 945215..946423
             49% to CYP107AN1 
MHHPTEPPPELWSAAAISDPYPIYDRLRAEQPIRWTGGDWQIFR
YADAQALLRDPRLGADRLQVDPQWLIASGLEPLFKTRDSMMLFADPPDHTRLRTLVHR
AFTPRVVESYRPLVQRIVDQLLDAAAARGAIELIGEFAYPLPVTVIAHMLGVPVNMHD
QFRRWSDSLAAFIGGTTRPEADVLPAALKAVLEMTDFFLALVAERRRAPRDDLLSALA
QAEDGGDRLSEQELVANSILLLLAGHETTTNLIGNGMLALMRHPDQFALLRDHPELTP
SAIEELLRYDSPVQVTSRRALTDIEFQGHRIEEGQAVTVFIGAANRDPAQYQDPARLD
VTRGDVRHLSFGHGPHYCLGAPLARLEGQVAISALVRRFPHMRTLDEQVVWRDNFALR
GLQSLHIELE

CYP107BA1    Roseiflexus sp. RS-1, complete genome.
             GenEMBL CP000686 REGION: 4471138-4472327 (-) strand
             Frameshift at 4471920
             46% to 107B1, 46% to CYP107AZ1 
4472327  MTPTIVARLASPEFLADPYPVYRQLIEQTPVFWLPHANAPGGMWCIARYDDIAFVLREAPIFKDT  4472133
4472132  SRIAPPDTLTPLDRAMLQRDPPDHTRLRRLASHAFTPRRVHDLMPRIEQI  4471983
4471982  SLDLIERIGARGEADFIADYA  4471920
4471920  PLPIIVIAELLGVPFEDHEQFSTWSDQIMAGSDSVLGGEEAARQSHQAMASLVDYFTTLI  4471741
4471740  RQRRHSPRDDLISALIAAHDAGDSLSEDELLGMCVLLLIAGHETTVNLIGNGLLTLLRH  4471564
4471563  PDQLNLLRRQSEYLTSAIEEMLRYESPVQRSTPRFAAEPFVIGGEQIEAGQQISLMFGAA  4471384
4471383  NRDPAHFSDPDRFDITRQPNPHLGFGMGIHYCLGAPLARIEARVAFTHILERLPAIRLAT  4471204
4471203  DTPAWKPVTWLRGLKSLPVLV*  4471138

CYP107BB1   Streptomyces sp. Tu6071
            ABB69746
            PlaO2
  1 MDRVLDFLSS ADSAGELQPR LVELSRQETL PRVLLADGQE AWLVTRNEDV RTVLSDRSFT
 61 RDVMGERARQ AGETPDGARS VNMDGRPHNE LRALVSKAFT VRRIEAMRPR IQAWTDELID
121 AMEETGPPAD LVAHLAVPLP ALAICELLGF PVEDRQVLSG WCERITRLGE GGPDQRAWQE
181 LSAYIARRVP VERAAARGGL APETSILTRL VHAHDSEDAL SMEELLSLTV VVLAGGLETT
241 QTAIGAGMVR LFRNPAQLDK VRADPDLVVP AVEEILRYQP VIDVNRVQVA TRTVRLGGQE
301 IRAGDLVQVS VNAANRDETV FPDSERCDVT RGPNPHLAFG YGAHHCLGAA LARLELKTAF
361 STLLRRLPDL RPAVPLESLG WRGGHVTLGL EELPVAW

CYP107BC1   Streptomyces sp. Tu6071
            ABB69764
            PlaO5
  1 MTESLETTSP DPTRSGNSDT GATPGYTVPK QVNDMWREKP VRRFSMRDGR EAWLVTGRAE
 61 VRTVLADPRF SRVEARRLDA VMSPAVIFTR PGILDMDPPE HTRLRRLVAG EFSARRMRAL
121 RPRIQQIADE LIGTMKAAGP PADLAEGLSY PLPIAVICEI LGVPYADRER FRAWADRVSA
181 PGTQPQEAMA ALRSLFDYMG GLVDDKHAHP DGSLLHGLVT ARDEQGRLDN EELVTLGCGL
241 LLAGYETTAT MLGKGLLALL DNPDQLAVVR SDPRAVPAAV SEVLRHVTPG VDPHTGLIRA
301 TTADVELGGT VIPAHSVVVA CNTAANFDPA TFRDPDRFDV TRENAAAHLT FGHGMHRCVG
361 AQLAQIELEA AFAALFPAIP GLRLAVPADE ITYTQSTLIR GLRSLPVLW

CYP107BD1  Frankia alni ACN14a
           YP_713426.1, no CAJ# found for this seq
MAETGGFAEVGGVAQTGGAREIFDPRWRSDPYPLYRTLRESARCHWLSPARIGVLTRHADCVAVLQDSAW
GHVPMETSAFRPVTDQDEGLRSMLRANPPTHTRLRRLVSRAFTPARIARFRPMAEALAGELLAAAVDRGE
VDLVEAFTRPLPLRVICSLLGVPAHDEKVFSGWASALTRGLDPDQVLDPVERAQRTEATRAFADYFTALI
ARRRAEPADDLLSDLIAVQDQGDRLGADELLEICVLLLVAGYDTTVNLVANAVLALARDPGQYAALQANR
TLVPAAIEETLRHDPPVQWTGRTALTDTDLAGQAFRAGDGIILVAGAAHRDPAAFPDPDRFDLTRYASAS
APAARHLGFGHGLHYCLGAPLARLEAETMLTALLDRVARLEIVAEPTYRPHLAVRGVDALQIRLHPAG

CYP107BD2  Frankia sp. CcI3
           YP_480713.1
           ABD10984.1
           57% to CAJ61859
           53% to CYP107BE2 YP_001505774 EAN1pec
           46% to CYP107AT2 Saccharopolyspora erythraea
           46% to CYP164A2 Mycobacterium smegmatis
MDADSPSGAAAVGTPPAFGAFDPARRHDPYPSYHALREADPFYRLPLGAQQVTLLTRYQDCMHVLQDAAW
GRGEGGTNAWRSANSFDGGLRSLLGVNPPDHTRLRGLVSKAFTPRVISGLRPQITVLVESLLDAALAAGE
VDLIDAFARPLPLRIICDLLGVPVRDEETFRAWGTALTRGLDPDYLLTPDELALRGKATVEFDAYFTDLI
AARRARPTDDLLGLLVAVREQGDSLTEAELLELCALLLVAGYETTINLIGNAVLALLRDTDQLTALRADP
DLAPALVDETLRHDPPVQFVGRLALRGTEVAGHSFAAGEVGVIMLAAAGRDPRTFAEPDRFDIRRYAGPT
PAPRHLGFGLGIHYCLGAPLARLEAEIALQALVRRAGSLTPASDPPSYRPHLAVRGLETLPIRLSP

CYP107BE1  Frankia alni ACN14a
           YP_714400.1
           CAJ62848.1
           57% to YP_001505774 EAN1pec
           43% to CYP107AT2 Saccharopolyspora erythraea
MATVPASRSASERRSPLLAAFDAARQVDPYSTYRAIREADPLAGHDLAGHRVTLVTRHGDTAAVLQDPAF
GHGYKENISPFRPDGDADDGLESLLRSDPPDHTRLRRLVSRTFTPGTLVELAPDITSFVAGLLDAALEAG
EIDAIRALARPVPTRMICRLLGVPAADEKIFGEWSETLIRGIDPDFLLTPDEITERRRAARELDAYFRDL
IARVRVRPGTDLVSQLVAIHLGEDALTESEVLALCAVLLVAGHETTVNLIGGGVLALVQHPDQLALLRAD
PGLIPAAVEEMLRHDSPVQFIPRTALRDTEVGGRQFRRGEGALLLVGSANRDPDAFDEPDRFLVARYAGS
TPAARHFAFGTGVHYCLGAPLARMEAEIIFRLLLERTSELALIGSTPTYRNQSIIRGLQTLPLRLAA

CYP107BE2   Frankia sp. EAN1pec
            YP_001505774.1
            ABW10868.1
            45% to CYP107AT2 Saccharopolyspora erythraea
MTTVGGMDTSEGGTSAIIAAVTATRLADPYPRYREIREVGAFIPGEIADRTVTLVTRLAEASAVLAHPAV
GHGYTDGINYRTGMDDGLGSLLRADPPDHTRLRRLVGRAFTPAVIEALAPEVTSLANVLLDEAIERGEID
AVAAFARPLPLRLISRLLGVPAADEEEFGGWADALTLGLDPHYLLTDEAKAACNRAAVEFDAYFLDLIAR
RRKEPRDDLLSRLVAIHDRGDMLAERELLELCTLLLVAGYETTANLISGGILALTRNPGQLAALRADPAL
VGPAVEEMLRFDPPVQFIARTVLADAEIGGRPFARGDGAIMMIGAANRDPEAFDEPDRFLVARHTRSDRT
RRHLGLGVGIHYCLGAPLARLEAEIAFRALFSRTSSFALAEDTVAYREQIVVRGLKRLPLHLSA

CYP107BF1   Frankia sp. EAN1pec
            YP_001505776.1
            ABW10870.1
            43% to CYP107AT1 Saccharopolyspora erythraea
MSAAPQVVFDAFAPVYRSNPYPRYALVRESTALYPINPQIAMATRYEECSAVLTDALWGHGYEDGINPFR
PGVDPDDVPGSMLRMDPPDHTRMRGLVKRAFVPRHTEGLRPRVEGLVNELIDTAIEAGEVDLMEALARPL
PLTVIGDMLGIPPEDYTAVKKWSLEIVRGTDPDILQSPESLARRPEAMREFEAYFAGLIAQRRKDPRDDL
LSDLCAAQERDSVLSDREMLGLSVGLLIGGYETVSDLIGKGLVALLRNPDQVALWRSNPELAPYAVDELL
RYEPPVQFTHRVALEERELAGRAFARGEGVVVLIAAANRDPAVYSDPERLDITRFAGRSPAPRHLSLSEG
IHYCLGAHLGRLQTQIAVDTLLLRAPGLSLTDDEPVWRDTVAIHGLDTLPIRLRD

CYP107BG1  Frankia alni ACN14a
           YP_713424.1
           CAJ61857.1
           53% to YP_001508234 EAN1pec
           43% to CYP107AT2 Saccharopolyspora erythraea
MFPVPQVRGTEGAYEGAGFMTTAEIDGDRVDAHRVVDAHDVFDTAHRIDPYPRYRRLRQAGSPTPVRLGD
AEVTLMSRFSDCAAVLQSQAWGHGNVDRLSPFWDQQASLPGSFIRMDPPDHRRLRTLVNKAFSARMVADL
TPMITSLVDTLVDRALAAGGLDVISGLSAPLAQAMVGQRLLGVPAADAEMLRSWELAIARGTDPDALLSA
EDAARRDSAGANVVAYLQDLVARRKAHPEDDLLSRLVAVEESGEVLTAAEVLGICVLLLVAGMETSINLV
GNGILALLAHPDQLALLRARPELAPSAVEEILRYDTPTQFTMRVALTDTTVGERRFRRGDGAIVLMGSAG
RDTDVFDGGERLDVTRYAEPGRSPRHLGFSLGLHYCLGAPLARLEATTAIRTLVERAPALSLATDELSYQ
PSLIHRGLSSLPVDLSPAAA

CYP107BG2   Frankia sp. EAN1pec
            YP_001508234.1
            ABW13328.1
            43% to CYP107AT2 Saccharopolyspora erythraea
MVAAEVTAGVAAESAPVEFTAFHPTHKADPYAVYQRVREARPLCPFMLGDIPVTVLTRYADCEAVLQSDD
WVHGYDAGISPFRDGAASAPRSFLRMDPPDHTRLRGLVNKAFTPRIVNQMAPGIQALADRLVDGALATGS
IDVIGEYAALIASATLGHLLGVPDDVGASLRGWALAIARGTDPDNLLTEAELVARRQATQDFQAYFEELI
AQRRANPTDDLISRMAAARDRDDALSELELLGVSSLLVVAGMETSINYVGSAVLSLLRHPDQLALLRARP
ELLPSAVEEVLRYDPPTQFTMRTACRRTELAGHTFARGDGVLLVSAAAGRDPAAFTDPDRFDITRYHGPR
PARRHLGFSVGIHFCLGAPLARIEAAAAIGALVRRTTTLELAVDEAELVYLPSLIHRALATLPVRVR

CYP107BH1  Frankia alni ACN14a
           YP_713399.1
           CAJ61832.1
           56% to CYP107BH2 YP_001508236 EAN1pec
           45% to CYP107AT2 Saccharopolyspora erythraea
MPNRPPPLQEPAVDLGTDTSSVLAAGPATALTPPAALTVDQAALNIFDPAWHHDTFPNYQVLREAGPFAP
GPLGLRLVTRYREVEAILADSAWSHAEEGAIMHPDSDGSDLPTSFLWMEPPDHTRIRRLVGKAFSARRIE
ALRARVTEVAGGLVDAAIAAGEVDLVEAIAYPLPLTMIAELMGVPVADHAAVRSMSFGLARGLDPDVLLS
QAEIDLRRESAAAFREYFTDLVARRRADPADDLVSALALAEAEGDRLTADEMLSTLVVLLVAGHETTVSL
ISSTFLMLMRHPDQYAALRARPDLAAPAVDELMRYCTPSHLTTRVATRDVEVLGEQFAAGDGVIILLASA
NRDAGRYADPERLDLARYAGGAAVPRHLAFGRGHHYCIGAPMVRLEMELLLRTLARRAPRLTPLVDPPPY
RPNLVVRGIAELPVRIDG

CYP107BH2   Frankia sp. EAN1pec
            YP_001508236.1
            ABW13330.1
            42% to CYP107AT2 Saccharopolyspora erythraea
MTGPATSTPHAVAGAPAVPDAEAVLAQAVIESFDPAWRHDPYPAYGTLRRAGTFLPGPLAGTMLVPGHAE
CAAILADPVWSHAEESELLHPDSDVELPGSFLWMEPPDHTRLRGLVSRAFTPRTIEATRPLARRVVDGLI
DDALAAGELDLIEGLAYPLPLTMICELLGVPISEHPAVRRMSAGIARGLDPDVLLSPAELAARTAAVEEF
REFFGALVTARRADPRDDLISALAQVHAEGDRLTTTELLGTLLILVVAGHETTVNLIGNGVLALLRDPAQ
LDALRRDPGLALPAVEEILRFDAPAQVTTRTARAEVTVAGRTFTPGEAVICMLGSANRDPRAFDRPDEFL
VDRYAGGARVSRHLALGMGLHYCLGAPLVRLEVGEVLRGIATRLTGMTLLADPPPYRPNIVVRGMSSLPV
RVTGRPG

CYP107BH3P Frankia sp. CcI3
           YP_481037.1
           ABD11308.1
           50% to CAJ61856
           65% to CYP107BH2 YP_001508236 EAN1pec
           55% to CYP107P1 Streptomyces coelicolor C-helix region
MDSAAPSLGAPDWPARSDPEMEPPGHTRLRGLVSKAFTPRTIEGMRPWAEQVVDDLLSRLIQRGLTSLPL
SLTPGGVA

CYP107BJ1  Frankia alni ACN14a
           YP_713423.1
           CAJ61856.1
           73% to CYP107BJ3 YP_001508260 EAN1pec
           45% to CYP107AT2 Saccharopolyspora erythraea
MVTVQPASSEAYVPPNESSPEQTGARLLAKLFDPANRHDPYSIYTELRAAGPLHTGPFDLKLANRYADCA
AVLGSQEWGHDREPHQLHPTIPAEAFPASFLWMEPPDHTRLRGLVTKAFTARTVAALRPRIAALVDELLD
NALRQGEFDLIATIAYPLPLTVVCEILGVPAEDHPLVQVWSQALARAFDPDVLMTPEALAERNRAIPEFL
SYFRALVSRRRREATGDDLITQLAAVEEQGDRLTEEELLGTCVTLLIAGHETTVNLVGNGMMALIRHPDQ
VALLRERPELIGPAVDELLRYDSPIHMNTRAAKRELVVGGEVFAPGEGIVALIACANRDPLVYDDPERLD
VTRFHTSKPIARHLSFSLGHHYCLGAPLALLEMELLLAGVLDRVADMELLTDTPPYKPNMLIRGLAELPT
RFHAA

CYP107BJ2   Frankia sp. CcI3
            YP_481034.1
            ABD11305.1
            74% to CAJ61856
            76% to YP_001508260 EAN1pec
            45% to CYP164A2 Mycobacterium smegmatis
            45% to CYP107AT2 Saccharopolyspora erythraea
            45% to CYP107AE1 Streptomyces sp.
MAVTTDSVFAGADAGTGVAADHGKPLPDQAPDLLAALFDPANRPNPYPLYARLRAAGRLHETPFGLRVAT
RHDDCVAVLSNQSWGHDQEAHQLHPTLPAEEFPATFLWMEPPDHTRLRGLVSKAFTPGRVADLRPRITAL
VDDLLDTALRAGEFDLIETIAYPLPLTIICEILGVPAADHGIIQIWSQALARAFDPDVLMSPEALAERND
AIPEFLAYFRALVARSRRSGGDDLLSALAAVEEQGDRLTEDELLGTCVTLLIAGHETTVNLVGNGALALL
RNPDQTALLRDEPDLIRPAVDELLRYDSPIHLNTRAATREMTVGGRTFSPGEGVVALIACANRDPEAFDD
PDRLDVRRYVAGSGASRHLSFSLGHHYCLGAPLALLEMEIFLAGFLHRVRSAELLVDSPPYKSNLLIRGL
AELPVRFRG

CYP107BJ3   Frankia sp. EAN1pec
            YP_001508260.1
            ABW13354.1
            47% to CYP107AT2 Saccharopolyspora erythraea
MTTSTVVPTAGTGSSGPAGEESTALLAELFDPATRPDPYPVYSRLREAGALHATPFGLPVATRHADCVAV
LANQDWGHDLEAHQMHPTLPAESFPTTFLWMEPPDHTRLRGLVSKGFTPRSVQLLRPRITALVDELLDNA
LAAGEFDLVETIAYPLPLTVICEILGVPAADHPAVQVWSQALARAFDPDALMSPEALAERNRAIPEFLEY
FGALVERHRREPGDNLISALAQVEEAGDRLTADELLGTCVTLIIAGHETTVNLVGNGMLALLRNPDQLAL
LRAEPELIPAAVEELLRYDSPIHLNTRAAKRELEVAGRVFAPGEGVVALIACANRDPRAYPDPDRLDVRR
FTSSAGGPPARHLSFSLGHHYCLGAPLALLEMELLLAAFVRRVSHAEITDNNPPYKPNLLIRGLAELPVR
FRG

CYP107BJ4   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY940 59% to CYP107BJ3

CYP107BK1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9749 
           42% to CYP107AN1 Bradyrhizobium japonicum USDA 110

CYP107BL1X  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9870 
           51% to CYP107L1 Streptomyces venezuelae
           name changed to CYP107BM3

CYP107BM1  Streptomyces hygroscopicus ATCC 53653
           ACEX01000414.1 3915-5168 (+) strand
MSENAMSENATHLTPEQVEDPVRGYADLRTRDELPH
AVLPGLTTPVRLVTRYADVKAALTEPRLIRDRTRIPGDADEAQASDAQDELLEAASAGLP
AEYVKYFAGHLALFDGEEHAHRRAPLTRAFTARRIAALRTFVERTADALVAEAEANGGTD
LLGAFAYPLATQVICELIGVEERDRDQVCSWMRDFAFGDGSRAGEALVALVEYAKELIAR
RRAEPTEDLISALLDGDQLTEDDLIGIVFLLINTGITPPALFLAHAALALLDHPEQAARL
HAAPELLPRAVPELLRYVSIVRIGATLYATEDVDFAGTALRRGESVTVALLAADHDPEEF
GDGAGQLDVGREFGRGDGHLAFGHGAHYCIGAALGRLVTSVVLDRLFVRHDGLRLAVPRA
ELEFGHWPGDGFHLLRLPVRL*

CYP107BM2  Streptomyces sp. C strain C
           ACEW01000053.1 15059-16303 (+) strand
MNETVHHLSPDRLQDPATGYAGLGDGDGLPRVVLPGLRTPV
RLVTRYADVKAALTEPRLIRDRTKVPGATDGPDAQDELLAPLGDLPPEYARYVSAHLAFL
DGAEHARLRTPLTRAFTARRVASLRPFVEESAARLIGELAGRKEADLLNEFAYPLATSVI
CELVGVDEADRARVCDWIRDFAYGDGSRMGDGLAGVVEYVKALIARRTAAPADDLISALL
GGAREGGAGALDEEEITAMVFLLINTGITPPALFLAHAVLALLDHPGQLDRLRAEPELLG
RAVPELLRHVTLLRIGATLYATEDFVFAGTGLRRGDSVTVALLAANHDPAVYGEASARLD
VTREAARGRGHLAFGHGAHHCIGAALGSLVTGVVFERLLVRRPVPELAVARGELEFGHWP
GDGFHLLRLPVRL*

CYP107BM3  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee May 24, 2010
           Clone name SBI_9870 
           68% to CYP107BM1 69% to CYP107BM2, 38% to CYP107X3

CYP107BM4   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY4225 90% to CYP107BM1

CYP107BN1P   Frankia sp. CcI3
             YP_483188.1
             ABD13459.1
             40% to CAJ61641 same as ABD13459
             39% to CYP107AH1 Streptomyces peucetius
MQQCLGEAMRSLHDCAVEMVLREREEPGNGALGALTVVRDEDGTGFSDEELVSTVLLTAIAGYESTVVQI
GNGFLAMFRHPEQMEHLKRGRTDIAAAVEEILRYAQSSTGFAGMTYAMADVELGSVTVPAGATVFVSLDS
AARDEAHVDSPQRFELSRGSARHHVTFGSGHHYRA

CYP107BP1P   Frankia sp. EAN1pec
             YP_001505775.1
             ABW10869.1
             41% to CYP107AT1 Saccharopolyspora erythraea no heme signature
MPSRDIAAAGYMRSPRAKSTESREILMSVDETTEGCVTDANGNLIAYGATSCMVSQLEPSTDVNVSPPAA
APHTTFDEFHA FDVFDPEHWPNPYPRYAMARKARPLIRTPLGVHLVTRYQDCATILQDNNWSHAHKAELF
HPGVEHVDLPTSFLWMDPPDHTRLRALVSKAFTPRTVANLRPRIEQLVKDLFDAIIEAREVDVISALAYP
LPLTIIAELLGAPAEDHPDLQRWSRALARGFDPEPLLSP GNVTHAPMPPVSSWPTSADWAPGNGVSGTRR
AGKHALSVVNPVSTRRRLVTAGVEETDDWSGWLRERRHDDIPLSQRENPHERAVRSTTNTAGRTSGRKGG
PRSRRTEPGCRYRSACSCSRCRSCCRRCRTTPTSRAEQQIGVGATRR

CYP107BQ1P  Frankia alni ACN14a
            YP_715801.1
            CAJ64277.1
            56% to CYP107L3 Streptomyces tubercidicus (N-term lower case only)
MTIRTASQEVPMSPTDPIPLYgpqykrdpyplyrrlratgpvhrvrfpsgvigwlvtgyraahealndhr
lgknHALGTSDALSALIDEEGLRHLDLFSLRDILGDLPYDDKRSSVSRRYGPTSEQLRAEVRSDEDTRRL
YQGITRFLVEDTAEFVGSRSALQRECRQRAYGVIGRSRAWGRLVAEHHPRAVRLSIHPQRRGTSKFGIRL
LESSDAWMTPWHATVLRRADGASELMRRADAQRLGRLVTRDGRPSHFQAHAAV

CYP107BR1   Pseudonocardia autotrophica NBRC 12743
            AB456955
            vdh gene for vitamin D hydroxylase,
            50% to CYP107AF1 Streptomyces collinus
MALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGP
VWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLV
GRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAED
RDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDG
DRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEF
LRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDA
SGGVFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLS
RMPVTMGPRSA 

CYP107BR2   Geodermatophilus obscurus DSM 43160
            CP001867.1
            56% to CYP107BR1
MTAVDASVFEGSFWRDPYPAYERLRAQAPVREVALPRGGTTWLVTRYDDVRAAFTDPRLV
KDHRATLPPEVRAQAPRLPGPFGSMMILLDPPDHTRLRRLVSRAFTARRTAELRPRIEAL
AAALLDAVPETEPVDLLAGYAVPLPMAVICELLGVPDTDRDAFGTWSRALVDDQDDVDEQ
QATAGLAQYLYALVETKRRAPDGALISALVEVSEAGDQLSTEEVVAMGVLLLIAGHETTA
NLIGNAVLGVATDAALREHLLADPQRIPAAVEEFLRWDGPVHNAPLRFAAEDVEYSGTTI
PAGSVVTLSVGAANRDPGRFDRPELLDPDRETGGHLAFGHGLHYCLGAPLARLEGEVALR
SLLDRFPDLRLAVPPEELRHRRSVLVHALETLPVVLRPEAAGSASA

CYP107BS1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE12853707 41% to CYP107P1

CYP107BT1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE323 43% to CYP107AZ1

CYP107BU1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE8042 39% to CYP107L2

CYP107BV1   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY941 49% to CYP107BJ3

CYP107BW1   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6567

CYP107BX1   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR810
            39% to CYP107N1

CYP107BY1   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR895
            42% to CYP107L2

CYP107BZ1   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR3274
            39% to CYP107AF1

CYP107CA1   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR6789
            50% to CYP107E2

CYP107CB1   Bacillus clausii KSM K16 
            GenPept BAD63511
            45% to CYP107J3, 60% to CYP107CB2

CYP107CB2   Bacillus lehensis
            Ang Swi See
            Submitted to nomenclature committee April 15,2013
            47% to CYP107J3, 60% to CYP107CB1

CYP107CC1     Lyngbya majuscula (filamentous marine cyanobacterium)
              EMBL AAT12284.1
              UniProt tr|Q5V8A7|Q5V8A7_9CYAN LtxB OS=Lyngbya majuscula
              LtxB Lyngbyatoxin biosynthesis
              43% to CYP107E2 Saccharopolyspora erythraea NRRL23338
              40% to CYP107E7 SCY603 Streptomyces RK95-74
              39% to CYP107E1 Micromosospora griseorubida
              40% to CYP107N1 Streptomyces lavendulae
              41% to CYP107E4 Actinoplanes sp. ATCC 53771
MTNPFADPSRDYWVLCNAEGQYSLWPTSLEIPEGWQTAFGPESWQNCLDNVEKNWTDMRP
LSLLGQRKCPVPYPFREYVALNMDPIYASLQQRDEMLRISVPYGDDAWLASSYKHVKCVI
QDTRFSRETTKYDEARLTPIPIRTSVLGMDPPDHTRLREALAAALTPSHVEQMKPWITSM
TEQLIDDFVAQGPPADLVEQFALPFTGHITCELMGIPLEDRPQFKAWCDGFSSTSSLTKE
EVEVRMQAMYTYITELVGRRRESPSDDIISKLLQPEDKRLELSEIELIDLATILLLAGYD
STAMELANAIFVLLTHPEQTQLIREQPKLMPQAVQELLRYIPIDAHVTFARYATEDVQVG
NTLVRTGDAILASFPSANHDPAIFEDPHTFNIMRPRKPNFGLGTGIHSCAGKLLAVVELE
IALSVLIRRLPTLRLAIPAEEVPWQPGSLLRSTSKLPAEW

CYP107 fragment  Streptomyces noursei 
          GenEMBL AF071516 CDS complement(85..>519)
          putative P450 hydroxylase gene, partial cds.
          function="may hydroxylate a macrolide antibiotic polyketide moiety
          C-term only 63% to 107A2, 55% to 107A1
WTTPTRWSCSAPSLICLPRHGRNTAHRRTSRSHHPGRARRHPDR
DTLIPARSTVFIAGAAANRDPQKFPNPDTFDITRNTQGHLAFGYGVHHCIGRPLAQME
GEVAITALLRRFPHLHLTTPSQNLTWRRSFLRGLTALPVTLN

108 Family

CYP108A1    Pseudomonas spp.
            Swiss P33006 (428 amino acids) PIR S27653 A42971 (428 amino acids)
            Also found a PIR cross-reference to EMBL S39894 but could not 
            retrieve it
            Peterson J.A., Lu J.-Y., Geisselsoder J., Graham-Lorence S.,
            Carmona C., Witney F., Lorence M.C.
            Cytochrome P-450 terp: Isolation and purification of the protein 
            and sequencing of its operon.
            J. Biol. Chem. 267, 14193-14203 (1992)

CYP108A1    Pseudomonas spp.
            GenEMBL M91440 (6620bp)
            Hasemann,C.A., Ravichandran,K.G., Peterson,J.A. and
            Deisenhofer,J.
            Crystal structure and refinement of cytochrome P450terp at 2.3A
            resolution.
            J. Molec. Biol. 236, 1169-1185 (1994)

CYP108B1    Mycobacterium smegmatis
            MSMEG1429 TIGR, 
            71% to CYP108B2 68% to CYP108B3
            84% to CYP108B9 Mycobacterium vanbaalenii
            72% to CYP108B8 Mycobacterium vanbaalenii
MFLTPVKFSPSEVPD
MSTPVINDAARVLAEPRAYADEPRLHAALAELRSQTPVAYVDVPGYYPFW
AITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIRTLIH
MDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPECDFV
QEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSSAEEL
NAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGEYLNDVDCLSYYV
IVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMPLATEEIIRWSA
PVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEIFENADKFDVGR
DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEFMAT
TFVGGLKHLPIRYSVR

CYP108B2    Mycobacterium smegmatis
            MSMEG1428 TIGR 
            71% to CYP108B1
            68% to CYP108B3
            87% to CYP108B8 Mycobacterium vanbaalenii
            73% to CYP108B9 Mycobacterium vanbaalenii
MSTPTMDDAAKALADPTAYADDARLHEALARLRAENPVAWVDQAPYRPFW
AITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGLRTLIH
MDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGPECDFV
TDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGTTVEEQ
MAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDGELMSDMDTLSYYV
IVASAGHDTTKDAISGGLHALIENPGELARLKADPGLMGTAVEEMIRWST
PVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSGNRDEEVFTDPFRFDVGR
DPNKHLAFGYGVHFCLGAALARMEMNSLFSELLPRLDSIELAGEPELSAT
TFVGGLKHLPIRYSIR

CYP108B3    Mycobacterium smegmatis
            MSMEG2261 TIGR
            68% to CYP108B1 68% to CYP108B2
            73% to CYP108B7 Mycobacterium vanbaalenii
            69% to CYP108B8 Mycobacterium vanbaalenii
            69% to CYP108B9 Mycobacterium vanbaalenii
MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFW 
AITRYADIMAIERANDLFTNSPRPVLMTAEEDEQQAAVGISTLIHMDDPQ 
HRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGGECDFVQEITV 
NYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALL 
EMFQYFTELTASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAA 
GHDTTSATISGGMLALLEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAF 
MRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH 
VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGG
LKHLPVRYALR

CYP108B4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3999
           72% to 108B3
           name changed to CYP108B4

CYP108B4   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 108B4 M. marinum = ortholog
           name changed to CYP108B4

CYP108B5   Mycobacterium avium subsp. paratuberculosis K-10.
           NP_961305, AAS04688.1, 
           79% to 108B7, 75% to 108B3
MSTTTMDEAA KLLADPMAYT DEQRLHAALT HLRANAPVSW VEVPNYKPFW AITKHADVMD
IERENMLFTN WPRPVLTTAE GDEMQAAAGV RTLIHMDDPQ HRVVRAIGSD WFRPKAMRAL
KVRVDELAKI YVDKMLAAGP ECDFVQEVAV NYPLYVIMSL LGLPEADFPR MLKLTQELFG
SDDSEFKRGS SNEDQLPALL DMFGYFNGVT AARREHPTED LASAIANARV DGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLQRLRDNL DLMPLATEEM IRWVTPVKEF
MRTAAKDTVV RGVPIAAGES VLLSYVSANR DEDVFDEPFR FDVGRDPNKH LAFGYGVHFC
MGAALARMEV NSFFTELLPR LKSIELTGDP ELVATTFVGG LKHLPVRYSL A

CYP108B6   Mycobacterium flavescens PYR-GCK
           ZP_01192125.1, EAS11507.1 
           92% to 108B7, 74% to 108B3
MSVRVADEAG KVFADPTAYA DEQRLHAAMT HLRANAPVSW VDVEGYNPFW AITKHADIMA
IERDNTVFTN SPRPVLTTAE GDAQHASMGV STLIHMDDPQ HRKVRAIGAD WFRPKAMRAL
KVRVDELAKT FVDQMYDRGG ECDFVQEVAV NFPLYVIMSL LGIPESDFGR MLTYTQELFG
SDDAELQRGT TMEERGLALF DMFTYFNELT ASRRAQPTED LASAIANARI NGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLARLQQAP ELLPLAVEEM IRWVTPVKEF
MRTAQQDTEV RGVPIAAGES VLLSYPSGNR DEDVFTDPFR FDIGRDPNKH VAFGYGVHFC
LGAALARMEI NSFFSELLPR LTSVELAGRP EHIATIFVGG LKHLPIRYSL TR

CYP108B7   Mycobacterium vanbaalenii PYR-1 
           ZP_01203876.1 EAS24868.1 
           73% to CYP108B3, 73% to CYP108B9, 70% to CYP108B8
MSVRIADEAARVFADPSAYADEARLHAAMTHLRANAPVSWVEVPGYNPFWAITKHADIMAVERDNLVFTN SPRPVLTTAEGDAQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRVDELAKTFVDQMYERGG ECDFVQEVAVNFPLYVIMSLLGIPESDFQRMLTYTQELFGNDDAELQRGESMEERGLALFDMFTYFNEIT AARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIENPDQLQRLQQNP GLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKH VAFGYGVHFCLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR

CYP108B8   Mycobacterium vanbaalenii PYR-1 
           ZP_01205329.1, EAS26321.1 
           87% to 108B2
MSTPTMNQESQEAAKVLADPTAYADDQRLHKALAHLRANDPVAWVDHPPYRPFWAITKHADIMAIERAND LFLSEPRPVLVTAEADDMARAQLEAGFGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKIRVDELAKRY VDKMRDIGPECDFVTEIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGATVEEQMAVLTD FFNYFGALTASRRANPTDDLASAIANGLVDGELMSDVDTLSYYVIVASAGHDTTKDAISGGLHALVENPG ELARLQGDLDLMPTAVEEMIRWSTPVKEFMRTAAEDTTVRGVPIAKGESVYLAYVSANRDEDIFDDPFRF DVGRDPNKHLSFGYGVHFCLGAALARMEINSLFSELLPRLDSIELAGRPELSATTFVGGLKHLPVRYSLR

CYP108B9   Mycobacterium vanbaalenii PYR-1 
           ZP_01205327.1, EAS26319.1 
           84% to 108B1
MSTPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNE LWINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIY VDKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITD FFRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQD QLARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKF DVGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR

CYP108B10   Frankia sp. EAN1pec
            YP_001507052.1
            ABW12146.1
            54% to CYP108B8 Mycobacterium vanbaalenii
MDIEAAATVFTDPRAYADNERFHTATALLRRESPIHRIEHPNFHPFWAVTKHEDVMAISRASDIWINEPR
PALGPKPKDAERENIPIRSLVQMDAPDHPVYRHVSADWFKPAGVRRLRDRIAELAKRFVDRMADQGGECD
FFTDIVSHYPLYVILSLLGLPEEDFPRMLRLTQELFGADDEDLARDQDKQAQRAPLVDFFNYFQALIQDR
RENPTDDLGSVIANATIQGEQIGKLEAAGYYTLIATAGHDTTSAALAGGLHALLESPGQWQRLVDDPRMV
ATGVDEMIRWVSPVKHFMRTAREDTVVRGVALAAGESVLLSYPSANRDEDVFENPDTFDVGRSPNRHVAF
GFGAHYCLGTHLARLEGQALYAELVPRVRSIELAGTPEYMEALFVGGPKRLPIRYTMA

CYP108B11   Frankia sp. EAN1pec
            YP_001507026.1
            ABW12120.1
            57% to CYP108B6 Mycobacterium flavescens
MGFRSRALVIDNIPNRRASALGSLPLGSPWRGTHEGGPGMDIAEAATVFTDPTAYADNQRFHTATALLRR
AAPVQRVEHEDFESFYAITKHDDVMTISRGSDIWRNAPRPALGPKPKDGRAAEDAPVRTLIQMDAPDHPV
YRHISAEWFKPLGVRRLAGRIAELAKRYVDTMADFGGACDFFADVACHYPLYVILSLLGLPEDDFPRMLK
LTQELFGANDPDMARGSGDEQALMAALLDFFTYFQALTADRRANPTDDLASVIANATIDGEPIGELEAIG
YYVLIATAGHDTTSSALAGGMHALLQYPDQWRRLSENPGLVPTAFDEMIRWVTPVKQFMRTAARDTEIRG
VPIAAGESVLLSYPSANRDEDVFDNPDTFDVGRTPNRHVAFGFGAHYCLGTHLARLEGQALYAELVPRLR
SIDLAGTPEYMETLFVGGPKRLPIRYTMT

CYP108B12P  Frankia sp. EAN1pec
            YP_001509055.1
            ABW14149.1
            67% to CYP108B7 Mycobacterium vanbaalenii PYR-1
MDLDEAGSVFTDPTAYADEKRWHTATALLRRHSPVHRVESAGFAPFWAVTRHEDVFTDPEAFDVGRTPNK
HVGFGFGAHYCLGTHLARLEGRALYTELVPRLREVELAGTPEYMQTLFVGGPKHLPIRYTIT

CYP108C1    Saccharopolyspora spinosa strain NRRL 18395
            No accession number
            Istvan Molnar
            Syngenta Biotechnology, Inc.
            47% to CYP108B1 43% to CYP108A1

CYP108D1    Novosphingobium aromaticivorans
            GenEMBL NZ_AAAV01000137
            16805..18166 gene = Saro1710
            47% to 108B1 39% to 108C1 
MTNTSRLTKRRRPRRSDGKREGFMDSIPMVPAEVGRAVIDPKSY
GTWEPLLDRFDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKST
VFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRK
IANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDE
DMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEP
MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPGIVEEAIR
WTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANRH
LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRW
KAA

CYP108E1    Ralstonia metallidurans
            GenEMBL NZ_AAAI01000348
            46192..47481 gene = Reut4024
            41% to 108B1 39% to 108A1 48% to 108C1 
MTIASDFDTELASHEIYSDPERMHEMFETLRREDPVHWTTAPGH
PPFWAVTKQADVIEVGKHPDVFIASPKSFLMNDVEQRVRIEETAATGGKLVRTMIHMD
DPDHKKYRGLTQSYFMPANIKRLESVIQERARALVGRLIEKGTSEFCSEIAVWYPLQI
VMTLLDVPESEHPYLLKLTQQFLAPKDPTLRRDGPDERGKGAVAKEYFAYFGKMLAER
RAAPLKEDLGSLIAHATVDGEPLPLMEAVSYYVILATAGHDTTSSSMCSGLYYLLTQP
GELDRLRARPELMPSAIEEMFRHGSPVKHFVRTATRDFELRGKKIQAGDEVALMYHSA
SFDEEVFDEPRSFRIDRGPNKHVAFGFGIHACLGQNLARASMRTFFTELLARTESIEV
VGKAEFIASNQVGGMKTLNIRVTPSKQSTTDRIEVAA

CYP108F1X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3999
           46% to 108B1
           name changed to CYP108B4

CYP108F1X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 108B4 M. marinum = ortholog
           name changed to CYP108B4

CYP108G1    Caulobacter crescentus CB15
            GenEMBL AE005918 GenPept AAK24465
            NC_002696 complete genome 2703947..2705221
            Complete genome sequence of Caulobacter crescentus
            Proc. Natl. Acad. Sci. U.S.A. 98 (7), 4136-4141 (2001)
            47% to CYP108A1
            formerly 108B1 but this was already assigned to 
            an M. smegmatis seq. (my error)
  1 MTISTDIANT IIDPKAYADG DRIDQAFAHL RREAPLAVAQ PDGFDPFWVV TRHADILEVE
 61 RQNELFHNGD RATVVTTIEP DKKVREMMGG SPHLVRSLVQ MDNPDHFAYR KITQGALLPQ
121 NLRALEARIR EIARGFVDRM AEHGDRCDFA RDVAFLYPLH VIMEVLGVPE SDEPRMLKLT
181 QELFGNADPD LNRTGKSVTD VGEGVDSIQS VVMDFMMYFN AITEDRRANP RDDLATLIAN
241 GKINGEPMGH LEAMSYYIIA ATAGHDTTSS TTAGALWALA ENPDQFAKVK ADPSLIPGLI
301 EESIRWVTPV KHFMRTATAD AELGGQKIAK GDWIMLSYPS GNRDEAVFED PFTFRVDRTP
361 NKHVAFGYGA HICLGQHLAR MEMRVLWEEL FARLDHVELD GAPTRMVANF VCGPKSVPIR
421 FKMH

CYP108G2    Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            67% to CYP108G1 Caulobacter crescentus AE005918
            Ectocarpus sctg_1 159023-157728

CYP108G3    Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS63163.1 (protein)
            CDS complement(1684831..1686087) locus_tag="Plav_1544"
            56% to CYP108G1 Caulobacter crescentus
MTDKTIDNAIVNPKTYAHVDEFHRLFTQLRKEEPVRWTEPDGFRPFWTVSKHADIMEVERQNDKFLNDPR
LTLQTIEVEEEVKKFTGGNSKLIRSLVDMDNPDHRNYRGLTQAWFMPPNLKAISARVEALAEKYIDRLEA
KGGECDFVSDVAVWYPLRVIMTVLGVPAEDEPIMLKLTQELFGSTDPDMKRPDATETVNTVTEFFNYFTA
MTEDRRKNPKDDVASVIANATIDGEPIGHLEAISYYIIVATAGHDTTSSTAAGGLLALMQNPEEFAKLKA
NPEGLLGGAIDEMIRWTTPVKHFFRTAAVDYELRGQKIKAGDNLLMCYWSANRDEEAFDDPFSFKIERSP
NKHLAFGYGAHLCLGQHLAKMEIRALYKELLARLDHIELAGDPAWVEASFVSGLKRLPIRYSMKRKAA

CYP108H1    Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            49% to CYP108G1  Caulobacter crescentus CB15 AE005918
            Ectocarpus sctg_1 1535540-1536841

CYP108H2    Marine metagenome 1093018949056
            AACY022454370
            57% to CYP108H1
APPRRGPQQSAEHTETWNRVYKEFEEYYEPVIKDRQTCPREDLASLISNGKIDGCPMEHR
AQISYFIIASTAGHDTTSATLATAISVLAERPEVLEQLKANLELIPAFIEETIRWASPVK
HFLRHATQDYELRGQQIKKGDLMYLSYISGNRDEDLIEDPFEFRIDRKPNRHVAFAFGNH
ICLGQHLARLELKIMLEELLPRLESLQLTGKPKLAISDLVCGPKSVPIQYDFKRTA*

CYP108-un1   Mycobacterium smegmatis
             MSMEG4159 TIGR (pseudogene)
             47% to 108D1
             158 residues. 39% to Msmeg_CYPXXII
LTDHYAMAHPKALNDTPDTAQPGQPQTRNPTTPGDLPPLQFFARTVHAET
SLGGVQFSENQRLVMNLAAANRDPRQFDDPESFDADRPRNPHVAFGGGLH
SCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLMAVISLPVA
FTPERSQT 

109 Family

CYP109A1    Bacillus subtilis
            GenEMBL M24523 (3187bp)
            Lewis,P.J. and Wake,R.G.
            DNA and protein sequence conservation at the replication terminus
            in Bacillus subtilis 168 and W23
            J. Bacteriol. 171, 1402-1408 (1989)

            Ahn,K. and Wake,R.G.
            A unique open reading frame adjacent to the replication terminus 
            of the Bacillus subtilis W23 chromosome compared with Bacillus
            subtilis 168
            unpublished (1990)

            Ahn,K.S. and Wake,R.G.
            Variations and coding features of the sequence spanning the
            replication terminus of Bacillus subtilis 168 and W23 chromosomes
            Gene 98, 107-112 (1991)

CYP109A2    Bacillus megaterium DSM319
            YP_003597238.1
            Elisa Brill
            Submitted to nomenclature committee 4/17/2013
            57% to CYP109A1

CYP109B1    Bacillus subtilis
            GenEMBL AF015825 Z99110  
            YjiB
            also similar to CYP106A, both 106 and 109 are close 
            together on a tree

CYP109C1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_111
            49% to 109B1

CYP109C2    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_8140
            69% to 109C1, 43% to 109B1

CYP109D1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_4257
            43% to 109C1 39% to 109A1

CYP109E1    Bacillus megaterium DSM319
            YP_003599057.1
            Elisa Brill
            Submitted to nomenclature committee 4/17/2013
            46% to CYP109B1, 44% to CYP109A2

110 Family

CYP110A1    Anabaena sp. (a cyanobacterium)
            Swiss P29980 (354 amino acids) GenEMBL M38044 (5933bp)
            GenEMBL U38537, M13161
            Lammers,P.J., McLaughlin,S., Papin,S., Trujillo-Provencio,C. and
            Ryncarz,A.J.II.
            Developmental rearrangement of cyanobacterial nif genes: 
            Nucleotide sequence, open reading frames, and cytochrome p-450 
            homology of the Anabaena sp. strain PCC 7120 nifD element
            J. Bacteriol. 172, 6981-6990 (1990)
            This sequence was later revised to give a complete P450 sequence 
            of 448 amino acids.

CYP110A1    Nostoc sp. PCC 7120 same as Anabaena sp. PCC 7120
            GenPept BAB73407, C37842 (this entry missing N-term)
            NC_003272 complete genome 1708114..1709493
            1 aa diff to M38044
  1 MLTQLPNPIS VPSWWQLINW IADPIGFQKK YSKKYGNIFS MQLAGIGSFV ILGEPQALQE
 61 IFTQDSRFDV GRGNTLAEPL IGRTSLMLMD GDRHRRERKL LMPPFHGERL QAYAQQICLI
121 TNQIASEWQI GQPFVARSAM QKLSLEVIIQ IVFGLADGER YQQIKPLFTD WLNMTDSPLR
181 SSMLFLKSLQ KDWGTWTPWG QMKHKQRSIY DLLQAEIEEK RTKENEQRGD VLSLMMAARD
241 ENGQAMTDEE LKDELLTILF AGHETTATTI AWAFYQILKN VNVQEKLQQE LDRLGANPNP
301 MEIAQLPYLT AVSQETLRMY PVLPTLFPRI TKSSINIAGY QLEPDTTLMA SIYLIHYRED
361 LYPNPQQFRP ERFIERQYSP SEYIPFGGGS RRCLGYALAL LEIKLVIATV LSNYQLALAE
421 DKPVNVQRRG FTLAPDGGVR VIMTGKKSLK FEQSSKIFN

CYP110A2    Anabaena variabilis (a cyanobacterium)
            GenEMBL U38478 (1743bp)
            Lammers, P.J. and Duran, S.
            possible alkane/fatty acid hydroxylase

CYP110B1   Nostoc sp. PCC 7120 Same as Anabaena
           GenPept BAB75445, AC2274 
           NC_003272 complete genome complement(4523158..4524546)
           45% to CYP110A2 53% to 110E1 49% to 110D1 47% to 110C1
  1 MHLPKGPQTP VFVQVLRWVF SPMSFLEDCA KRYGDIFSVK LAKDVPAIVF LSNPKDIQQI
 61 LTNDNNQLDS PGDWNDLFEP LLGKRSVITL SGAEHQRQRQ LLMPPFHGER MRGYSQVITD
121 VTEKVISQHQ IGQPFQVRSV TQAITLRVIM QAVFGLYEGS RAEKLQHLLS DLLEKSSSPF
181 SVALLYFPSL RRDFGPIKFW GEQVQIQQQA DELIYQEIQE RRENPDPSRT DILSLLMDAR
241 DADGQPMTDV ELRDELMTLL VAGHETTATA LAWAMYWIHK LPPVKARLLE ELDSLGDNPD
301 STTIFKLPYL NAVYSETLRI YPVAMLTFAR RVIETMALGG YELPPGTPVL GSIYLTHHRE
361 DLYPEPKKFK PERFLERQFS PYEYLPFGGG TRRCLGLAFA QWEMKLALAK ILTSYELELV
421 NNSVEVRPKR RGLVTGPHRP IEMVIKSQRQ ITSRILETTT VS

CYP110B2   Nostoc punctiforme
           NZ_AAAY02000005 GenPept ZP_00111619.1
           complement(58895..60277) gene = Npun6097
           75% TO 110B1
MKLPKGPQSPAVLQMLRWITSPMSFMETCAKRYGDMFTIRLDSK
SPPLIFVSKPEVLEQILTNDIKGLEAPGDTNLVFESLLGKHSVITISGAEHQRQRQLL
LPPFHGERMRSYSQIISDITEKVISQYQIGQPFNIRSVTQAITLRVIMQAVFGLDEGP
RAEKLQHCLAEMLEKGSSVLSAALLYFPALQRDFGPINFWGKQMRRQQAADKLIYEEI
RERQEQPDPSRTDILSLLMAARDEAGQPMTDEKLRDELMTLLVAGHETTATALAWAFY
WIQKIPTVRQKLLKELDSLGDNPDPSTIFKLPYLNAVCSETLRIYPVAMLTFARVVRT
PLSLGGYELEPGIGVIGSIYLTHHREDLYPEPKQFKPERFLERQFSPYEYLPFGGGAR
RCIGLAFAQLEMKLALAKILSTRELELVDNSEVRPKRRGLVTGQDRPIQMVVTSQRQV
KFPILQTATV

CYP110C1   Nostoc sp. PCC 7120 Same as Anabaena
           GenPept BAB76385, AF2391         
           NC_003272 complete genome 5587079..5588485
           48% to CYP110A2 49% to 110E1 47% to 110B1
  1 MKYQIQRPNP LKTHPFLQKL QWIADPVEYM KKASLQHPDM FTAEVIGFGD TVVFVSHPQG
 61 IQTLFANDRK KLVAVGEANR ILYPLVGNNS MFLLEGVKHK QRRQLLMPSF HGERMREYGH
121 LIRNITENLF SQLQQDVTFS ALTAMREISM QVILQAVFGF YEGERCQQFK HLLPIFLSEL
181 FQSPLASSIL FFPSLQKDLG NLTPWGRFVR QREKIDKLLY AEIAERRQEI NSDRIDILSL
241 LISARDETGD SMSDKELRDE LITLMISGHE TTGTAMAWSL YWILQTPEVF QRLIQELDSL
301 GDSPDPMSIF RLPYLTAVCN ETLRINPVAM LTLPRVVKEP IELLGNRLET STTVVGCIYL
361 THHREDLYPE SKLFKPERFL KREFSQYEFM PFGGGVRGCI GQALAMFEMK IVLATVLSRY
421 QLALADRKPE RPQRQGFTLT PTNGVKMLIT GQHKRQNYSM AASTTFNA


CYP110C2   Nostoc punctiforme
           GenPept ZP_00108280.1
           GenEMBL NZ_AAAY02000070 complement(34550..35941)
           gene = Npun2703
           60% to 110C1
  1 MQLPNILKSP SLLQKLHWVS DPIGYMENAA QEYPDIFTGK IVGFGDTVVF VNHPQAIQEI
 61 LTNDRKKFTA VGELNGILKP LLGDNSVLML ESDRHKRQRQ LVTPSFHGER MQAYGQLICN
121 VSKKIFNQLP LNKPFVARNL TKEISLQVIL QSIFGFYEGE KIQKLRQLLP LLLELFESPL
181 SSSLFLFSFL QQDLGAWSPW GNFLRVREKI DQFLYTEIAE CQQQADPERI DILSLLISCR
241 DEAGQPMTDQ ELRDQLITLI LAGYDTTATA MAWGLYWIHK QPLVCEKLLQ ELDTLGDSPD
301 PMSISRLPYL TAVCNETLRI HPVTMFSFPR VVQEPLELLG HSLEPGTILL PSIYLTHHRE
361 NLYPQSKQFK PERFIERQFS PYEFLPFGGG VRRCMGEALA LFEIKLALAT IVSHYHLALV
421 DQRPEQPQRR GFNLAPGSGV KMVMTDQRAR KESLINMTTT PLS

CYP110C3   Anabaena variabilis ATCC 29413
           YP_322498 
           95% to 110C1
MKYQIKRPNPLKTHPFLQKLQWIADPVEYMEKASLQHRDMFTAEVIGFGDTVVFVSHPQGIQTIFANDRK
KLVAVGEANRILYPLVGNNSMFLLEGVKHKQRRQLLMPSFHGERMREYGHLIRNITETLFSQLQQNVTFS
ALTAMREISMQVILQAVFGFYEGERCQQFKHLLPVFLSELFQSPLASSILFFPFLQKDLGNLTPWGRFVR
QREKIDKLLYEEIAERRQEINSDRIDILSLLISSRDETGNSMSDQELRDELITLMISGHETTGTAMAWSL
YWILQTPEVFQRLIQELDSLGDSPDPMSIFRLPYLTAVCNETLRINPVAMLTLPRVVKEPVELLGNRLES
GTTVVGCIYLTHHREDLYPESKLFQPERFLKREFSQYEFMPFGGGVRGCIGQAIAMFEMKIVLATVLSRY
QFALADGKPERPQRQGFTLTPANGVKMLITGKHQRQNYSTAASTTFTT

CYP110C4   Nodularia spumigena CCY9414
           ZP_01629302 
MSTPNRLKTPAFFQQLQWVADPVGYMEKAAQQYPDIFTAQVVGFGNNLVFVNHPQAMQEILTNDRKKLFA
GGKENKILQPLLGDYSMIMLDGDRHRKRRQLVMPSFHGDRMRSYGEIISNITEEVWSNLPTDKSFLARNV
TQDITLQVMIQAVFGVYQGERSQQLKKQLELMANIFRSPLSSSMLFFSSLQQDLGAWSPWGKFVRDRQEL
DNLIYTEIAERRQQNLENRIDILSLLMSAEDESGNPMTVQELRDELMTLLFAGYETTATALAWGLYFIQK
HPEVQEKLLQELDTLGDSPDPMSIFRLPYLTAVCNETLRIHPVAMLTFPRTVKEPVEISGYALDPGTILV
GSMYLTHQREDLYPEPKQFKPERFLERQFSPYEFIPFGGGVRRCVGEALAVFELKLVLATILSRYELALT
DDQPEVPRRRGVTLAPGRGVNMMITGQRLA

CYP110C5    Crocosphaera watsonii WH 8501
            ZP_00518945 
MKTIPTPKTPTLVQQLQWVLNPTGYLQTNHHRYPDLFKAKIIGLGNDIILISNPEIMQYILTHDRQEFTA
PSSLNTLLKPLLGDYSVVMLDGDGHRQRRQLVMPSFHGERLKVYGDLTCRITREAMEKLPENQPFLAREV
MQDISLKVIMEAVFGVTEGERYEELQYRLKELLDLFDSPITSGFLFFPSLQKDLGNWSPWGYFLRQRQAL
DKLIYAEISDRRANPDPERTDILSLLMFAKDEQGESMKDQELRDELITLLMAGHETTASAMAWALYWLHH
IPEIKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRLAQQTVEVGGYTFKPGDIVA
GCLYLTHLREDIYANPKQFNPQRFLDHKYSAYEFIPFGGGSRRCMGEALAKFEMKLVIAIIISEYCLKLA
DTQPEKQQRRGLTLSPKRGVKMILEGKRQPQKARELELSTR

CYP110C6    Cyanothece sp. CCY0110
            ZP_01731952 
MKTIPGSKTPKLIQQLQWIFNPTKYLKTNHRRYPDIFKAKIIGFGDKMILTSRPEIMQYILTHDRKQFTS
PSGLNAILRPLLGDSSVLMLDGDRHRQRRQLVMPSFHGERLKVYGDLTCRITEEVMAKVPQNQPFLAREI
MQDISLKVIMEAVFGVTEGKRYEQLQDRLKKMLDLFNSPLTSAFLFFPFLQKDLGSWSPWGHFLRQRQAI
DELIYAEISDRKAHPDSDRTDILSLLMSAKDEQGQGMKDQELRDELMTLLTAGHETTASAMAWALYWIHH
TPEVKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRVAQEKVEVAGYTFEPGDMIM
GCMYLTHLREDLYTNPEQFNPQRFVDRQYTPYEFIPFGGGSRRCVGEALAQFEIKLVIATIMSQYCLKLA
DTQPEKQQRRGVTLSPARGVKMILEGKRQPQPVRELELSRQ

CYP110C7    Lyngbya sp. PCC 8106
            ZP_01620519 
MKTLNSPKTSPLIQRLQWVFNPLEYMETNVKINRDIFNTQVTGGVGLIFVNSPEGMQELLTRDTKEFYAP
GSINEILKPLLGEQSVMLLDGDRHKRQRKLLMPPFHGERMRTYGELILNITQQATAKLKPGQPFIARNAM
QEITLAVILQAVFGIYEGSRYDKLKQLITSLLAVTDSPVSSSLLFFTSLQKDWGAWSPWGRFLRMRQKVD
QLLFAEIEERRQNWDENRTDILNLMMAARDEDGQPMADEELRDELLTLLVAGHETTATAMAWALYWIHRQ
PEVYQKLIQELESLPENADPMTIFRLPYLTAVCNEALRIYPVAMLTFPRVTKEPTQLLGYELEANIGLAG
CIYLLHHREDLYPEPKQFKPERFLERKFSPYEFLPFGSGARQCIGMALAQFEMKLALAQILLDYDLTLLE
KRPVKAARRGVTLSPVGGIKMMMNGKRTPSKSVAIPATV

CYP110D1   Nostoc sp. PCC 7120 Same as Anabaena
           GenPept BAB76465, AF2401
           NC_003272 complete genome 5678382..5679743
           48% to CYP110A1 53% to 110E1, 49% to 110B1
  1 MTVTQNLPNG PRIPRLLRLF KFITQPIQYV EDFAKVYGDN FTIWGSGESY FVYFSHPQAL
 61 EQIFTNVSCF ESSGGGSPLL ELLLGKNSLI LLEGDRHQRQ RQLLTPPFHG ERMRAYGQTI
121 REITQQVTQA WQMGKPFNIR ASMQEITMRV ILRVVFGVDE GELFQELRQL LTTLLDFMGS
181 PLMSSTFFFS FTQKDYGAWS PWGRMVRLIK KIDQLIYALI AQRRAEFGEN RQDILSLLIS
241 ARYDDGQPMS DVELRDELMT MLVAGHETTA SALTWAFYWI DSVPEVREKL FQELDTLNDD
301 SEPSIIAKLP YLTAVCQETL RFYPIVLNAF FRRTKNPMEI MGYKLPKATL VVPSIYLAHH
361 REEVYPQSKQ FRPERFLEKQ FSPYEYLPFG GGNRRCIGLA FAQYEMKIVL ATILSQFQVS
421 RLSKRPVQPV RRGLTLAAPG GMKMVANKRM RNS

CYP110D2   Nostoc punctiforme
           NZ_AAAY02000028 GenPept ZP_00109203.1
           52704..54170 gene = Npun3650
           68% to 110D1
MNIPLSVTLSNMKSRNNKIQKPSNLQTPMTATYNLPDGPQMPRW
LRTIKFISQPVKYVDDFAKTYGDTFTIRSSRSDNHIVYFSQPQALEEIFTADSRHFEV
GRGNTGLRFLLGDRSFMLVDGDRHQRQRQLLAPPFHGERMRAYGEDIRKITQQVSHEW
KIGKPFNIRESMQEITLRVILRVVFGLNEGELFEELRRSLSDLLDFISSPIMSSAFFF
RFIQKDFGAWSPWGRILLQRQKVDLLIYTLLRERRAQTDQNRQDILSLMMAARYDDGQ
GMSDEELHDELMTLLVAGHETTASALTWAFYWIDHLPEVREKLLQELNTIGVNPDLSS
VAKLPYLTAVCQETLRIYPIAMTAFVRIVKTPITIMGYELREGTAIVPSIYLAHHREE
VYPQSKQFKPERFLERQYSPYEYLPFGGGNRRCIGMAFAQYEMKIVLATVLSEFQVSL
VNKRPVHPVRRGLTVATPAGMRMVATPQVKRANTPALV

CYP110D3   Trichodesmium erythraeum
           GenPept ZP_00074554.1 GenEMBL NZ_AABK02000068
           complement(10019..11407) gene = Tery3870
           54% to 110D1
MTLPDGPSLSPLQRRLRTWKFIFSPLSAIEERYSEYGDIFRTNT
NSLYPFIYFCNPKAIQQIFTADPDTFTSGSINGILKYFVGLNSLLLQDGDRHKRQRKL
LMPPFHGDRMRKYGDLIYNITSNVISQWKIEQPFPIRKSTQEISLKVILAAVFGLDQE
GKSYEKLRVLMSDLLDSMSSPLSSTFLFFNFLRKDWGPWSPWGRFLRKKQELHELIIA
EIQTAKKEGNHRDDILSLLLEARDEAGNAMSDEEIKDELLTMLFAGHETTASALAWAL
YWIDMIPSVGEKLMAELATIPSNSDQVAITKLPYLSAICQETLRIYPIAMNAFPRVVQ
KPIEIMGYQLEPGMVAIVPIYLTHHREDIYPEPKKFKPERFLERQFSPYEYLPFGGGS
RRCIGSAFALFEMKLVLATILSQWELKLLPNQRISPVRRGLTMAPPANMRMVVKPKKS
WQKVSQPILTSG

CYP110D4    Lyngbya sp. PCC 8106
            ZP_01620515 
MTLPNGPQTPRVLRMMKFVARPLDYLEDYYRRYGDFIRIGKSATPLVYVNHPAAIEKIFTAGSEQFRTGN
AGGVLLFLLGDNSVLMVDGERHERQRKLLMPPFHGERLKTYNQLICEITKEVMSQVKIGQPFRVRTLMQD
ITLRVILKAVFGLTEGERYEQLRHLLSAMMESIGSPLAASLMFFPSLRQDWGEWSPWGRFLRYKQQADEM
IYAEIRERKQQRDFDGDDILTLLMSARDETGKPMNETELRDELVTLLIAGHETTASSLTWALYWTHYLPE
VKDKLCFELANLGENPHLSEIARLPYLTAVCNETLRIYPVTLTSGVRVLKKPLELGGYSFEPGTVLFPCT
YLVHQREDIYPEPKKFKPERFLQRQFSPYEFFPFGGGHRRCIGSAMATLEMKIALATILSDWQLKLPHHK
AYKPVRRGLTLSPPAQLSLVAVNRLN

CYP110D5    Crocosphaera watsonii WH 8501
            ZP_00513562 
MNLPPTLSQPRLLRLFKLIFYPLDYLEDNYQRYGDIFVAGKSETPFVYISNPQGIQTILTRDKTDFKTGG
GSGFLSTLLGDNSLLFLQGERHRRERKLLMPPFHGERLKSYANLIYSISDKVTDKLQINRSFNVRDIMQE
ITLKVILKAVFGITEGERYQRLQELLKSWLSFFDSPANAILIFFPWLRKNWGNWTPWGRFLQIKAEIQEL
IYTEIRERREQKKYEGTDILTLLMLAKDEEGKPLSDQELHDELITLLIAGHETTASALTWALYWIHFCPD
VEDKLRFHFSNLNNNTDLLDIVKLPYLDAVCKETLRIYPVLLTTFIRVLQTPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSQQFRPERFLERNFSPYEYFPFGGGSRRCIGMELAKMEMKIVLYTILSKHKLKLPSSR
PLKAVRRGLTVAPPSNFKMILSN

CYP110D6    Cyanothece sp. CCY0110
            ZP_01726400 
MVLPPSISTPRLLRLFKLIFYPLDSLENYYERYGDIFIVGQSETPFVYISNPQGIQEILTKDKTHFRTGG
GSGFLTTFLGNNSLLSLKGEKHQRERKLLTPAFHGERLQSYATLIYSISDEVSEKLEINQSFNVREIMQE
ITLQVILKAVFGIAEGKRYQKLKNLLTSWLSFFDSPINATIIFFPFLQKDWGNWTTWGRFLRIKAQIDDL
IYTEINERRQQKNYQGKDILTLLILARDEDGNPMSDQELHDELITLLIAGHETTASSLTWALYWIHYCPE
VEEKLRSHFSILDKNIDLLNIIKLPYLDAVCSETLRIYPVVVNAFIRVLETPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSKQFRPERFLERQFSPYEYLPFGGGSRRCIGMELAKMEMKIVLFTLLSKYKFKLSSSH
PLKPVRRGLTIAPPNSFKMIITQKLAYT

CYP110E1    Nostoc sp. PCC 7120 Same as Anabaena
            GenPept BAB76532, AI2409
            NC_003272 complete genome 5753083..5754450
            50% to CYP110A2 53% to CYP110B1 53% to 110D1
  1 MKLPDSPKIP KFMQLVQWIY QPLQLMEASA KAHGDSFTLW LTNKRPIVFL SNPQAIQELF
 61 TTPLEQLDAR GTAQVLQPLL GENSLLLLSG ETHQRQRKLL TPPFHGDRMR AYGDIITNIT
121 KEVISNWQLG KPFSVRDSMQ EITLRVILQA VFGLREGERY TQLQKRLCDI LDLSGSALRS
181 TLSFLPALQI DLGRWSPWGH FLRQREAIDQ LLYAEIQDRR DHPDPSRTDI LSLMMAARDE
241 NGEAMTDVEL RDELMTLLVA GHETTASALT WALYWIHKLP QVREKLLAEL DNFGDNGDVN
301 EITRLPYLTA VCQETLRIYP IAMVTIPRIT KTNLEIGGHQ FAPGTMLVGC IYLMHRRPDL
361 YPQPQEFKPE RFLEKQYSLY EYLPFGGSNR RCVGMAFALY EMKLILATVL ANVDLALVDN
421 YPVKPTRRGV TLAPSGGKWL IATAQHQKIK NPVEV

CYP110E2   Nostoc punctiforme
           NZ_AAAY02000088 GenPept ZP_00107327.1
           complement(18173..19567) gene = Npun1723
           58% TO 110E1 55% TO 110B1
MSLLKLPNGPQTHPWIQMYQWLTNPLEYMEACTKRYGDIFTLKL
GQNFAHQVFISNPQAIQQIFTTDPKQLDSGESAGIKAPLLGQQSLLALDGKPHQRQRK
LLTPPFHGERMLAYGELIREITEQVSSQWQVGETFAVLPSMQAISFQVILKAVFGLED
GPRYKKLNELLIKILNPKIPLLRTVLLIFPSMRQDLGAWSPWGKYLRLRQQIDQLIYA
QIQERKAQPNLSGTDILSLMMAARDEAGEPMTDLELRDELMTLLVAGHETTATSLSWA
LYWIHHRPQVREKLLQELDNLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMSALNRLV
KSPLQIGEYNFEPGTILIPSIYLTHHREDLYPESKQFKPERFLERQFSPYEYLPFGGG
NRRCIGMAFALFEMKLVLATVLSRWQMELADSKPVRPVRKGLLFSPAGGVQMVVKGKR
LQNQPILQTSSSSV

CYP110E3   Trichodesmium erythraeum
           GenPept ZP_00072591.1
           GenEMBL NZ_AABK02000017 complement(<3..1016)
           53% to 110E1 missing C-terminal 121 aa (runs off end of clone)
  1 MIKLPGPKSP ALTQILQWTA KPIKFMEKCA REYGDTFEVK LNYPIVFISH PKAIEEIFKA
 61 NPKKFDCGSS NKLAQPLLGD YSLLLLDDIP HQRQRKLLMP PFHGKRMQAY GELICNVAQE
121 VASKWEIGQV FSMREFTAEI SLKVILQAVF GLYEGERYSK LEKLLGSLLE SLSSPLKTSM
181 LFFQFLQIDL GPWSPWGNFI KNREEIYELL CAEISERRQK LDPERSDILT MLLLARDEEG
241 EGMSDIELRD ELMTLLIAGH ETTATSLSWA FYWIHHQPEI YQKLSRELET FGDDLNPMTV
301 INLPYMNAVC SETLRIYPVV IIVSPRKTKL PITIMGQT

CYP110E4   Gloeobacter violaceus PCC 7421
           GenEMBL AP006578 complement(257348..258724) 
           gene = gll3063
           NC_005125 complete genome complement(3256348..3257724)
           locus_tag = gll3063
           71% to 110E5 55% to 110E1
MSLPPGPSSPSPFQLMQWIGCPTDYLHTTAARYGDPFTMRVGVF
PPLVMFSDPRAIQQLFTAEAGTFDAGASNVALRPTLGANSLLLLDGERHQQQRRLLTP
PFHGERMRAYGELIRQVTEEVIVRWQPGKPFLVRNAMQRISLAVILQAVFGLHDGTRL
VRLRQALGSMLDAMSSPLSMAMLLMLPEDFGPWSPRARLQAHLGAIDELLYAEIRERR
EHFDAGAGDILGLLLAARDEAGAAMGDAELRDELMTLLVAGHETTATAMAWALYWIHY
LPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVALIASPRVARHTVRI
LERDYEAGTRLAAGIYLAHHRPETYPEPERFRPERFLERTFSPYEFVPFGGGSRRCIG
MAFALYEMKLVIATVLLERDLRLVQPRLLRPVRRGVTLAPPEGLYLVPTGERSASRLL
SRTSTAGQ

CYP110E5   Gloeobacter violaceus PCC 7421
           GenEMBL AP006578 complement(258800..260176) gene = gll3064
           NC_005125 complete genome complement(3257800..3259176)
           locus_tag = gll3064
           71% to 110E4 55% to 110E2
MSLPAGPASPPPLQLLQWIGRPTDYLERTARRYGDPFTMRLGLH
SPVTGVFFSSPEAFQQLFNTEPGLFDSGGANASSTFNLLFGTNSLILLDGERHQQQRR
LLTPPFHGERMRSYGELIRTLAEQVTARWNLGTPFQARRSMQRISLGVILKAVFGLHD
GTRYLRVCRLLGNLIDASASPLLFGLRLIFPQDAGPMSPMGQLKAQIDAIDELLYAEI
RERRERPDPRADDILSLLMAARDEAGQGMGDVELRDELMTLLVAGHETTATAMAWALY
WIHRLPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVAMVAFARVPRR
PVRILDREYPAGTFLIPNIYLAHRRPEAYPDPERFRPERFLERTFSPYEFVPFGGGSR
RCIGVAFALYEMKLVLATVLSRVELRLADPRPRLPVRRGLTLAPPEDLHLIPTALRSG
HRDLLPAC

CYP110E6   Anabaena variabilis ATCC 29413
           YP_322620 
MKLPDSPKIPRFMQLVQWIYQPLQLMEASAKAHGDCFTLWLTNKRPIVFLSNPQAIQELFTTPLEQLDAR
GTAQVLQPLLGENSLLLLSGETHQRQRKLLTPPFHGDRMRAYGDIITNITQEVISKWQLGEPFSVRDSMQ
EITLRVILQAVFGLREGERYTQLQKRLCDILDLSGSALRSTLSFLPALQIDLGSWSPWGHFLRQRAAIDQ
LLYAEIQDRRDHPDPSRTDILSLMMAARDENGEAMTDIELRDELMTLLVAGHETTASALTWALYWIHKLP
QVREKLLAELDNFGDNGDVNEITRLPYLTAVCQETLRIYPIAMVTIPRIVKTTLEIGGHQFAPGTMLVGC
IYLMHRRPDLYPQPQEFKPERFLEKQYSLYEYLPFGGSNRRCVGMAFALYEMKLVLATVLANMDLALVDN
YPVKPTRRGVTLAPSGGKWLIATGQHQKVKSPVEV

CYP110E7   Nodularia spumigena CCY9414
           ZP_01631632 
MPALQLPDGPKNHPWLQTYRWLTSPLEYMEDCAKNYGDIFTIRVGPLSTPQVFVSNPQAIQQIFSTDPKY
LDSGAAAGFKSPLLGNQSLLSLDGKPHQRQRKLLTPPFHGERMLAYGELIRDISQQVTNKWQVGETVSVL
SSMQAISFQVILKAVFGLAEGPRYEKIKEALIAILNPKKPLLRSMLLMFPSLRRDLGAWSPWGEFLRLRQ
QIDELVYAEIQERKAQLDSSRTDILSLMMATRDEAGEPMTDLELRDELMTLLVAGHETTATALSWALYWI
HHQPQVREKLLQELDTLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMLLLSRLVKSPLQIGEYQFEPGTL
LIPCVYLTHHREDLYPDSQTFKPERFLERQFSNSEFIPFGGGNRRCIGMAFALFEMKLVLATVLSNWQME
LANTQPVLPVRKGLLFGPKGGVQMVVKGRRELS

CYP110F1   Nostoc punctiforme
           NZ_AAAY02000005 GenPept ZP_00111618.1
           complement(57031..58407) gene = Npun6096
           48% TO 110E1 48% TO 110D1
MKILDSLTTPSLLQTLQLIAKPTKTLENYATKYGDIFTMRVMGL
KSPPIVFFSHPQAISDCFAVPAHKLDFKKATHVFKPLFGENSIVFKEARSHQQQRQLL
LPAFHGDNLKSYGQAICQIAEELTQSWTSGTNICIHKLMSKITLEIILQVVFGITHGV
RYQQLKEQLSALLEDVTKPWYSSLFFFPSLQKDLGAWSPWGIFLKRREQIDKLIYAEI
SERRWQNDAMRTDILSLLMSAHDVNGQQMTDEELRDQLVSLLLLGYETTSGVLAWIFY
LIHSHPEVKHRLMQELSTLDNLTNPEAITQLPYLTAVCQETLRIHPIALICTPRMLKE
PVEIMGHKFTSETVLVPCIHLAHRRTDTYPEPEQFRPERFLNQKFSPYEYLPFGGGYR
GCIGAAFSMYELKLVTAIILSRFELSLTDKRPAYPVRRGITIVPSGGVKMVVTKKAKF
KRQTILST

CYP110G1   Trichodesmium erythraeum
           GenPept ZP_00074734.1
           GenEMBL NZ_AABK02000081 complement(2404..3738)
           42% to 110C1
  1 MKQVCALKTP LWLQRFNYIT NPVSYWQKAY SSYKDAFYAQ GINFGKPLMV FYTPSAAKQI
 61 IENCQGDLTT TSFDSELTAI FGDSSFFILE GTNHKKMRKL LIPALHGKHI KTYGELICNL
121 VNNLIENLPF NQSFSALEIA QEISMQVMIK LLFGNYQQER YQKIKQLMIN MVSLFAANVF
181 GFPLFFKFLQ QDLGLVSPWG NFLQQRRKIQ QLIYQEIAER RNHPNQERTD ILSLLMTAQD
241 EKGNFLNDEE LLGQLLSLLF TGNESTAASI AWSWYEVYRN SKIKEKLLEE INNLGDSPEP
301 LSLFNLPYLS AVCNETLRKY PVTMFMIPRI VKNTTEINGY QLDKGMLVTV GTYILHHRED
361 IYDQPEEFKP ERFIEHRFSS FEFLPFGRGM RGCIGADIAL YQMKLTLATI ISHHRLELTN
421 YGQIFPKRRN TILTPIKLRI IKAC

CYP110H1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_2802
            44% to 110E4, 43% to 110E2

CYP110J1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_5885
            41% to 110E4 46% to 110H1

CYP110K1    Cyanothece sp. CCY0110
            ZP_01731775 
MTATIKAKKSNNLAFPQGIKRYGLKGILNLIFRPLPTLEAYRNRYGDIYYSPAFSSFPPFIVVSNSEGVE
ALFTADPDLFNSGTSNAAFQPLLGSQSILQLDGEPHKKRRKLLMPSFHGQRLQTYGEIITNITQSIISHW
QKEDIFSMREVTQEITLSVILQAVFGITQGNNYQSLRKQLGRYLDLFNSPLYTSTLFLPILQKNWGTWTP
WGNFIAQRDKVYELLSQEIDKRTTTKDGEDILTLLLSVIDEEGEHLTKSEVMSELMTLLFAGHETTASAL
AWAFYWIHFHPEIYHNLKDELDTIDLDTDPMEIAKLPYLSAVVSETLRIYPIALFAFSRTLTTSWEFMGY
SLDKGMSLAPCIYLVHHHPDIYPNSKQFKPERFLERQFSPYEFIPFGGSNRRCLGYALALYEMKLVLATV
LKQVNLKLVSSQPILPVRRGFTMSPQGGVKMQVI

CYP110L1    Synechococcus sp. CC9311
            YP_731620 
MLEAILRPIAYYRRCFFRNSGVVRVRMSPTLPPQQVLISDPSVIKELINEDGGRHITAPGQLNGLLSQVL
GKHSIILLAPATHRQRRKLLTPPFHGERLKAYGQLISSLADQSLIDLNVGDVFDAREQMQGITMRVILTA
VFGLHEGDAFRQLERSLASSISIRSGPLGSLLLFFPFLRRDLGRWSPGGRIKAADAAIRRLLLEQIASRR
RAVERCGEENMSADILSLLLSCKDDEGQGLSDDELHDELLTLLFAGHETTATALTWAFYWIHRNPLVLER
LMNELNGLLDHSDPEAIARLPYLSAVVNEVLRIHPVAMLTFPRRIESAITLGGYAFRSGDVVMACIQAVH
ERPDLYPKPLQFNPERFMNQTYGLHEFLAFGGGSRRCIGAALALYEMKLILAKILLNNQFELTPKSNRWN
KPRRRGFTLGPSIPVKLKMVSLRP

CYP110M1    Lyngbya sp. PCC 8106
            ZP_01619763 
MRLPDGPRLPALLQTLQIIAQPTQFLERCANQFGDCFTLRVLGFNSPPIVFFSNSEAIEAIFTTDTDKFE
LGKITHVFQPLTGSQSLIMQDGKRHQRLRQLLMPSLHSKQLPAYGQTICNLTLKATQNWSPGDFISIRDY
TSEIALEVILQVVLGLKENRRYFQLKHLIEPYLESVNKPLNSIQFFLPPLQQNLGQKSPWGKFLKQRKKI
DDLIYAEIAERRTKPLGEDVLSLLISAKDEAGQPLTDQELRDQLITLLLLGHDTTASALAWAFYWIHRYP
KIVNQLVEELNSLGENPDPMDIVQLPYLNAVCQETLRIHPIALISQPRVVKESIKIENYQFKPGTILVPC
IHLAHHREQIYPNSKQFNPNRFLEQKFSPYEYLPFGGGNRSCIGMALSLFEMKLILATILLNYQLAFNQS
HVVKPVRRGITIVPSINFRLTVLTRKQAGIASKSVNH

CYP110M2    Synechococcus elongatus PCC 6301
            YP_170898 
MLPPGPSQLALLQTLRIITQPVSFLLSCADRYGDWFTLRVLGPQSPPVVFVSDPEAILAIFSSLADQLEL
GRIADVFRPLVGNESLIMQNGDRHRQQRQLLMPALQGERLFDYTPAMTAITQAAIAQWPLGQPLDLRRQM
SQISLAVILQVVFGLTPGPRYRDLYQRLDQLLEAITDPLYSLQFFWPALQQDWGNWSPWGRFCRQREAID
ALITAEIQEGRQSQQPRQDVLELLLAARDRDGNPLSDQELRDQLMTLLLLGHETTASALTWAVFWLLRHP
DCLNRLQSELVAIGDNDRAIAKAPYLDAVCREALRLQPIALIAQPRRVASPLSLGGYDFASGTILVPCVL
TAHRRAATYPNPDQFQPNRFLERRFSNGEFLPFGGGQRSCIGMALSLIEMKMVLATLLRQCQIAEVSQRP
VRPARRGITFVPSQDFRIQVQQWHNPSAQTAIASV

CYP110N1    Lyngbya majuscula (filamentous marine cyanobacterium)
            EMBL AAY42399.1
            UniProt tr|Q1EDA9|Q1EDA9_9CYAN HctG OS=Lyngbya majuscula
            http://www.ncbi.nlm.nih.gov/pubmed/18001088
            HctG in the hectochlorin biosynthetic gene cluster
            54% to CYP110E2 Nostoc punctiforme
            53% to CYP110E7 gi|119512554| ZP_01631632 Nodularia spumigena CCY9414
            52% to CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena
            52% to CYP110E6 gi|75908324| YP_322620 Anabaena variabilis ATCC 29413
            53% to CYP110B2 Nostoc punctiforme
            51% to CYP110B1 Nostoc sp. PCC 7120 Same as Anabaena
            49% to CYP110D4 gi|119486457| ZP_01620515 Lyngbya sp. PCC 8106
            47% to CYP110C7 gi|119486461| ZP_01620519 Lyngbya sp. PCC 8106
            45% to CYP110M1 gi|119485435| ZP_01619763 Lyngbya sp. PCC 8106
            46% to Q1EDA8|Q1EDA8_9CYAN HctH OS=Lyngbya majuscula
MKLPPGPQTPAILQMIEWVFHPSKLMQTCAQRYGDTFTVKVGPNLAPVVFLSDPKAIQKI
FTADLKQFETGKLNKIAQPLIGEYSLMLQDGKYHQRQRRLLMPPFHGERMRRYNKIIDDI
AKQVISQWPEGKPFSIRPSIGKISLELIVECVFGLRKGPRSQHLIQLLTLMAEYTSKPLA
IALVSCKPMQRDFGSWSPWGSFIRLKQQITKLIYDEIGERRSQFDSSRTDILTLLMSARD
EDGMPMTDVELHDQLITFLMGGHDTTTTALVWAFYWIHYLPEVREKLLRELDSLGDDLEE
SNIIKLRYLNAVCSETLRINPISVLTLFRSVKSPLQLMSYQYDPGTILAGCIYLTHRRED
LYPEPEKFKPERFLERQFSFYEYLPFGGGNRRCVGDALAMFVMKRVIATVLREKQLTLVD
RRPVKPVFRGPGLAPSGSMQMVAVTKK

CYP110P1    Lyngbya majuscula (filamentous marine cyanobacterium)
            EMBL AAY42400.1 
            UniProt tr|Q1EDA8|Q1EDA8_9CYAN HctH OS=Lyngbya majuscula
            HctH in the hectochlorin biosynthetic gene cluster
            48% to CYP110E2 Nostoc punctiforme
            47% to CYP110D4 gi|119486457| ZP_01620515 Lyngbya sp. PCC 8106
            49% to CYP110E6 gi|75908324| YP_322620 Anabaena variabilis ATCC 29413
            49% to CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena
            48% to CYP110E7 gi|119512554| ZP_01631632 Nodularia spumigena CCY9414
            46% to CYP110 Lyngbya majuscula (marine cyanobacterium)
            45% to CYP110C7 gi|119486461| ZP_01620519 Lyngbya sp. PCC 8106
            43% to CYP110M1 gi|119485435| ZP_01619763 Lyngbya sp. PCC 8106
MMKFPDGPKTPALLQSINLIVNPLNYLEDCAKRYGDIFTIRFLNYPPTVLVSHPQAMKEI
FTASSQTFNTGEAMKELPTAFTGENALPLLDGDLHKHRKRMLMPAFHGERLRAYSELIYD
LTKQEIEQWTKGEPFHVQASMQDISLKFIIRAIFGVNDEDRFQQFKKTLISLLNLLSDPW
TSIVLYFRALQQDWGSWSLWGRFVRLRQQVDDIIYAEIKRRRDDPALLGEDILSLMMSAR
NEQGELINDVELRDDLMILLLGGHETTSMSMTWALYWIHHFPQVYETLMAELDTLDDYQD
SSAIMKLPYLDAVCHETLRIYPPTILGAYRIAQKPVEIMSHKFEAGTFILPCIYLTHRQE
DLYPEPNHFRPERFLERQFSAYEFVAFGGGSRRCIGYALSLFEMKLILATILTNLKLALP
DNRVIKPVRSAFTVAPSPMYMIRA

111 Family

CYP111A1    Pseudomonas incognita
            GenEMBL L23310 (2080bp)
            Ropp,J.D., Gunsalus,I.C. and Sligar,S.G.
            Cloning and expression of a member of a new cytochrome P-450
            family: cytochrome P450lin (CYP111) from Pseudomonas incognita.
            J. Bact. 175, 6028-6037 (1993)

CYP111A2    Novosphingobium aromaticivorans
            GenEMBL NZ_AAAV01000134
            complement(20145..21356) gene = Saro1618
            65% to CYP111A1
MLDLKNPDTYQGGVPYAALQDLRAEGPVHWNPESDGAGFWAVLG
HDEIVAVSRQPDLFSSAFENGGHRIFNENQVGLTGAGESAIGIPFISRDPPSHTQYRK
FVMPALSPARLQGIEERIAKRVERLFAQVPLGETVNILPLLTVPLPLLTLAELLGVPA
DLWPDLHRWTDAFVGEDDPDFRQSPEAMQAVLAEFMGFATALFEDRRANPGPDIASLL
ANTEIRGEPAPLRDFIANLILALVGGNETTRNSINHTMIALAENPGQWDILRADPSLM
TAAVKEMVRFASPVIHMRRTAMRDTQLGQQAICKGDKVVIFYPAGNRDPAVFENPDRF
EITRPVRQHLAFGSGAHVCVGSRLAEMQLRLAFAEMARHVRAFEVVGEPSRVRSNFIN
GFKRLEVRLLV

CYP111B1    Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS61652.1 (protein)
            CDS complement(33622..34875) locus_tag="Plav_0029"
            49% to CYP111A1 P450 lin L23310 Pseudomonas incognita
MLRPQAKAIDLNGKPDLKDPDLYLHEQHHEAFRRLRAEEPVYWNPEADGPGFWAVTRYDDIEAVSKNPKL
FSSAKHNGGHRIFNENEIGGNDTDASMISMDPPAHAGYRRMVTPGFVPKRISNMEERIRARVTRLLDAMP
KTGEAEFISAVAAALPIEVLAELFGVPESDGPKLFEWSNATVGEDDPELRVSDEYMQKCIMEMAGYAAGL
WQQRLETPGDDLISMLAHSKIGGEAMNFPTYIGTFILLVVAGNETTRNSISGGLLALSENPGERQKLLDD
PSLIPSAVQEIVRWVSPVLHMRRTATEDTELRGQKIRKGDKVVMWYASGNRDEAQWADPYRFDVARYAAP
GVPAQIGFGVGQHFCLGSRLAELQLTILFEELLRRFPDINVSGPIRRLRSNFIYGIKEMPVSYTPEG

112 Family

CYP112A1    Bradyrhizobium japonicum
            GenEMBL L02323 L12971 U12678 (11,715bp)
            NC_004463 complete genome 2317922..2319127
            Tully,R.E. and Keister,D.L.
            Cloning and mutagenesis of a cytochrome P-450 locus from
            Bradyrhizobium japonicum that is expressed anaerobically and
            symbiotically
            Appl. Environ. Microbiol. 59, 4136-4142 (1993)
            Note: called BJ-1 see CYP114, CYP115P, CYP117

CYP112A2    Rhizobium sp. NGR234 plasmid pNGR234a
            GenEMBL   AE000083 
            NC_000914 complement(233666..234868)
            Gene = y4lD
            Freiberg,C., Fellay,R., Bairoch,A., Broughton,W.J., Rosenthal,A.
            and Perret,X.
            Molecular basis of symbiosis between Rhizobium and legumes
            Nature 387 (6631), 394-401 (1997)
            about 92% identical to 112A1
MPEQPLPTLPMWRVDHIEPSPTMLALRANGPIHNVRFPRGHEGW
WVTGYDEAKAVLSDAAFRPAGMPPAAFTPDCVILGSPGWLVSHEGGEHARLRTIVAPA
FSDRRVKLLAQQVEAIAAQLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDHA
FFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPGDNLLTDLLAAVDR
GEATEEEAIGLAAGMLVAGHESTVAQIEFGLLAMLRHPQQRERLVGNPSLVDKAVEEI
LRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPRHFEDPEIFDIGR
DAKPHLAFSYGPHYCIGMALARLELKVVFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEFPVLW

CYP112A3v1  Mesorhizobium loti
            GenPept NP_106888                
            95% to 112A2 Rhizobium sp. NGR234
  1 MSEQPLPTLP MWRVDHIEPS PEMLALRANG PIHHVRFPSG HEGWWVTGYD EAKAALSDAA
 61 FRPAGMPPAA FTPDSVILGS PGWLVSHEGG EHARLRTIVA PAFSNRRVKV LAQQVEAIAA
121 QLFETLAAQP QPADLRRHLS FPLPAMVISA LMGVLYEDHA FFAGLSDEVM THQHESGPRS
181 ASRLAWEELR AYIRGKMWDK RQDPGDNLLT DLLAAVEQGN ATEEEAIGLA AGMLVAGHES
241 TVAQIEFGLL AMFRHPQQRE RLVGDPSLVD KAVEEILRMY PPGAGWDGIM RYPRTDVTIA
301 GVHIPAESKV LVGLPATSFD PRHFDDPEIF DIGRDENPHL TFSHGPHYCI GMALARLELK
361 VVVGSIFQRF PALRLAVAPE ELKLRKEIIT GGFEEFPVLW

CYP112A3v2  Mesorhizobium loti
            GenEMBL AL672112 complement(85404..86606)
            Strain R7A symbiosis island
            Gene = msi071
            2 DIFFS with CYP112A3v1

CYP112A4   Rhizobium etli symbiotic plasmid p42d
           NC_004041 55365..56645
           89% to 112A3
           gene = cpxP2
MSEQSLPTLPMWRVDHIEPSPEMLALRAKGPIHRVRLPSGHECW
WVTGYDEAKAVLSDAAFLPAGMPPADFTPDSVILGSPGWLVSHEGDEHARLRTIVAPA
FSNSRVKLLTQQVEAITVQLFDTLAVQPQPADLRRHLSFPLPAKVISALMGVPFEEHA
FFAGLSDEVMTHQHESGPRSASGLAWEELRAYIHGKIRGKRQDPGDNLLTDLLAAVDQ
GKATEEEAIGLAAGVLVAGHESTVAQIEFGLLAMFRHPQQRERLVRDPSLVDKAVEEI
LRMYSPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPCHFKDPEVFDIGR
DANPHLAFSYGQHNCIGAALARLELKAIFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEMPVLWCGRPPASQSSHLAAPGAHRSDQPLDR

113A Subfamily

CYP113A1    Saccharopolyspora erythraea
            GenEMBL L05776 (1320bp) S51613 U82823 PIR B40634 (412 amino acids)
            Stassi,D.L., Donadio,S., Staver,M.J. and Katz,L.
            Identification of a Saccharopolyspora erythraea gene 
            required for the final hydroxylation step in erythromycin
            biosynthesis.
            J. Bact. 175, 182-189 (1993)
            eryK erythromycin C-12 hydroxylase
            Note: two different database entries have different start 
            codons.  Neither is ATG.

CYP113A1    Saccharopolyspora erythraea NRRL23338
            SACE_0713, se: 778654,779847 (+) STRAND
            eryK - erythromycin B/D C-12 hydroxylase
LTTIDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHADVQTVLRDTATFSSDPT
RVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTPRTISDLEPRIRDVTRSLLADAGESFD
LVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQMDDPTDPALAERIADVLNPLT
AYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAANFSTALLLAGHITTTVLLGNIV
RTLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQMQRTTTKATEVAGVPIPADVMVNT
WVLSANRDSDAHDDPDRFDPSRKSGGAAQLSFGHGVHFCLGAPLARLENRVALEEIIARF
GRLTVDRDDERLRHFEQIVLGTRHLPVLAGSSPRQSA

113B Subfamily

CYP113B1    Streptomyces fradiae
            GenEMBL U08223 (7082bp)
            Merson-Davies,L.A. and Cundliffe,E.
            Analysis of five tylosin biosynthestic genes from the tylIBA 
            region of the Streptomyces fradiae genome.
            unpublished (1994)

CYP113B2    Streptomyces caelestis 
cytochrome P-450 hydroxylase homolog (nidi)
GenEMBL AF016585 CDS complement(1-396) N-term only, 60% to 113B1
MVDSVTGPMELSKDANAKELLDWFSHNRTHHPVFWDEGRQAWQV
FRYDDYLTVSNHPEFFSSDFTEVAPTPPELEMILGPGTIGALDPPAHGPMRKLVSQAF
TPRRMAGQEQRIRVIAEELLDRVRGQKTIA

CYP113B3    Streptomyces mycarofaciens 
            DQ672719.1 
            midM gene partial (missing C-term)
MSEAPTVPLELSKEANAQELLGLGSPSTGTHHPVFWDENWACLG
KVFRYDDYLTVSNNPQFFSSDFNEVMPTPPELEMVIGPGTIGALDPPAHGPMRKLVSQ
ALTPRRMARLGPRIRAVTQGLLDAVRGQETIDVVGDLSYALPVIVIAELLGIPSGDRD
VFRGWVDTLLTNEGLGYPSLPDNFSETIAPALKEMTDYLLHQIHAKREAPVDDLICGL
VQAEQDGRKLTDVEIVNIVALLLTAGHVSSSTLLSNLSLVLEENPQALADLRADRELV
TGAVEETLRYRSPFNNIFRFLKEDTDILGPEMKKGQMVIAWSQSANRDPEHFPEPDTF
DIRRSSSSRHMAFGIGIHHCLGAFLARQEGKVVLELML

CYP113C1   Streptomyces virginiae
           GenEMBL AB072568 4994..6202
           46% to 113A1
           gene = visD
MAQQTPPAPPSMADGGKAMLAWLRTMRDEHPVHEDQYGVFHVYR
HSDVLAVTSDPAVFSSDLSRLRPDSSALSEEILSVIDPPLHRKLRSLVSQAFTLRTVA
DLEPRVTELAGRLLEKVEGSEFDLVGDFAYPLPVIVIAELLGVPAEDRELFRGWSDRM
LSMQVDDPLEIQFGDEAGEDYERLVKEPLKEMHAYLQRHVDARRETPGDDLLSRLVTA
EIAGERLTDRQIVEFGALLLMAGHVSTSMLLGNTVLCLEENPETAAALRADRALISGV
IEEVLRMRPPITVAARVTTGEVVVGGVTIPKDRMVMASLLSANHDERHIQDPEVFDPR
RSPNPQLAFGHGIHYCLGGPLARLEGRVALEMLLDRFEDIRVTPGAPYDFHREGLFVP
ARSPLTVRRG

CYP113D1    Saccharopolyspora erythraea NRRL23338
            SACE_0229, se: 264665,265870 (-) STRAND
            45% to CYP113A1, 49% to 113C1
MSIPADTWGIPASQFWLRGRRPERTVDYDAATGMWNVYGYPEIQHVLSDPRTFSSDTTRL
MPAKVAERTSALSEGSLLQMDPPEHTKLRKLVSHAFTPKVVADLAPRIADLANELLDDVG
DRMEMVEDLAYPLPVIVIAELLGVPGSDRHLFKKWVDALLQRDQQFSLVDESDEQVQQVE
EAIAQVKHLTDYLGEHAAERRRAPREDLLTKLVQAEVDGHRLSDTEVVNFANILLLAGHI
TTTMLLGNTVLCLDTHPRQRDAVRADRSLVPSAIEESLRFFSPFAVLGRVTQREVEVGGQ
TIPQDQMLMLWIAAANRDPRQFADPDVFDVTRDPNPQIAFGRGIHFCVGAPLARLEGKVA
LNILLDRFPHLRTDPDEGPTFLPAPTTTGVRKLPLLLTPSA

CYP113E1    Salinispora tropica (marine actinomycete)
            Strop_0603 684254..685447 45% to CYP113D1, 
MATVPRLTFADGGVSVLPWFRQMRDDQPVWYDQGTGSWNVFRYADIAQILTDPATFSSDP
GRTMPPELVEEAEGSLVAVDPPRHGRLRALISTAFTPRLVEQLAPRVRSIAERLLDRTFV
DRGPEGEFDAIGDVAYLLPVYVIGELLGLPETDREYLVRTADEFYAISADDPFDGTYMAS
MQSTLDGLGTYMLDQAERRRARPGDDLMSALAHAEIDGEQLNDREIRNFAVLLLTAGHIT
TTALLGNTLLALGERRDVMLRWRHGQVDTADVLEEVLRHRTPFTEVYRFTTTEVTIGNQV
VPGDQLLRLWIASGNRDERQFADPDTFVLGRDSRHLGFGLGIHYCLGASLARMESSVVLE
VLAERTTTLAPAVQGLSYYDAPGIFCLRSLPVSYRRS

CYP113F1   Streptomyces sp. Tu6071
           ABB69748
           PlaO3
  1 MTASEEGTRL ADQSADAATM LAWFRRMRES EPVSHDEEAG VWHVFRHADV ERVLADPGTF
 61 SSDFSSFMPA QEDVDRFIKG NLLRKDPPQH RKLRTLVSKA FTPGVVARLA PRIEVIADEL
121 LDAKAGADQL ELVADLASPL PVTVIAELLG IPAEDRPMFG RWADSLVAPE SQTSFIPNED
181 RTKAMAVVMR EMNAYCLEHI RRRRAAPSQD LVSKLVAAEV DGQRLDDDEI IGFVGLLLLA
241 GHITTTALLT NVILCLDEFP DIAAALRADP SALPGAIEEV LRFRTPLAPS MRRTTREVRV
301 GEHTVPAGRI LLAWLASANR DERQFTAPDT FDIHRAPNPH LSLGHGIHFC LGAPLARLEV
361 RIAVEKMLGR WSGITVADGV ECHDARGIVG AKKLPLRLRW A

CYP113F2   Frankia sp. EAN1pec
           YP_001504963.1
           ABW10057.1
           56% to CYP113F1 Streptomyces sp. Tu6071
MSQLTTRPNAVRRSLPDLLRWLDELRRRGQVHRDDRQRCWHVLGHPEAGAVLADHRSFTSDLRGLLPRPE
DMPEYNLQEGSFQEDMELFQRGNFVRLDPPEHHRLRGLASRAFTSRTVAGLAPRIAEVTTELLDATGGRT
RLELIDDLAYPLPVIVIAELLGLPAADRPMFRGWADALFDREVADPDQPLTELAAANTRAAVPVLREMNA
YLLDRIRACRAHPGDDLTGRLVQVEVDGQRLADEEIVGFVGLLLLAGHITTTATLGNAALALDEHPGAAA
ELRAEPELLPATIEEVLRLRTPFPRLVRRAVADTRVGDEVIPAGAVVTVWLTAANRDERVFAEPDRFDPR
RAPNPHIAFGQGIHFCLGAPLARLEARTALGILLDRYSDIAVAADVPVEHRDPWAMVSVNSLPLDVRPR

CYP113G1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_3232 
           47% to CYP113C1 Streptomyces virginiae

114 Family

CYP114A1    Bradyrhizobium japonicum
            GenEMBL L02323 L12971 U12678 (11,715bp)
            NC_004463 complete genome 2319222..2320511
            Tully,R.E. and Keister,D.L.
            Cloning and mutagenesis of a cytochrome P-450 locus from
            Bradyrhizobium japonicum that is expressed anaerobically and
            symbiotically
            Appl. Environ. Microbiol. 59, 4136-4142 (1993)
            Note: called BJ-3 see CYP112, CYP115P, CYP117

CYP114A2    Rhizobium sp. NGR234 plasmid pNGR234.
            GenEMBL AE000082 CDS comp (9861..11264) gene = y4lC 
            NC_000914 complement(232170..233573)
            cytochrome P450 BJ-3 homolog" 90% to CYP114A1
MDMQETTTACADAFAELASPACIDDPYPFMRWLREHDPVHRAAS
GLFLLSRHADICWALKATGDAFRGPAPGELARYFPRAATSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTMREIDNLRPSIARFVAARLDGMAPALERGEAVDLHRQFALALPMLV
FAELFGMPQDDMFGLAAGIGAILEGLSPHASDPQLAAADAASARMKAYFGDLIQRKCI
DPRHDIVATLVGAHDDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPDQ
RHWLQGDAAGVEAFVEEVLRCDAPAMFSSIPRIAQSDIELSGVVIPKNADVRVLIAAG
NRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQLARVQLAESLPR
IQARFPTLTVAEQPTREPSAFLRTFRALPVRLHAQGDSPRLTSAFLNGQRGVEGGASF
EHGDGERRSATDRRAQP

CYP114A3v1  Mesorhizobium loti
            GenPept NP_106889          
            92% to 114A2
  1 MDVQETTAAC RDAFAELASP ACIQDPYTFM RWLREHDPVH RAASGLFLLS RHADIYWALK
 61 ATGDVFRGPA PGELARYFPR AETSLSLNLL ASTLAMKEPP THTRLRRLIS RDFTIRQIDN
121 LRPSIARIVA ARLDGMAPAL ERGEAVDLHW EFALAVPILV FAELFGMPQD DMFGLAAGIG
181 AILEGLSPHA SDPQLAEADA ASARVQAYFG DLIQRKRTDP RNDIVSMVVG AHDDDADTLS
241 DAELISMLWG MLLGGFATTA ATIDHAVLAM LAYPEQRHWL QGDAVGVKAF VEEVLRCDAP
301 AMFSSIPRIA QRDIELGGVV IPKNADVRVL IAAGNRDPDA FSDPDRFDPA RFYGTTPGMS
361 TDGKIMLSFG HGIHFCLGAQ LARVQLAESL PRIEARFPTL ALAEQPTREP SAFLRTFRAL
421 PVRLHAQGG

CYP114A3v2  Mesorhizobium loti
            GenEMBL AL672112 complement(84020..85309)
            Strain R7A symbiosis island
            Gene = msi070
            10 DIFFS with CYP114A3v1

CYP114A4   Rhizobium etli symbiotic plasmid p42d
           NC_004041 56651..58252
           90% to 114A3
           gene = cpxP3
MDVQDTTAACHDAFAELASPACIQDPYPFMRWLREHDPVHRAAS
GLFLLSRHADIYWAFKATGDAFRGPAPSELARYFPRAASSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTVGQIDNLRPSIARIVAARLDGMAPALERGEAVDLHREFALALPMLV
FAELFGMPQDDVFELSAIVSAILEGLSPHASDPQLAAADVASARVKAYFGDLILRKRA
DPRRDIVSTLVGAHTDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPEE
RHWLQGDAAGVEAFVEEVLRCEAPAMFSSIPRIAQRDIELHGVVIPKDADVRVLIAAG
NRDPDAFADPDRFDPVRFYGTRPGMSSDGKIMLSFGHGIHFCLGAQLARVQLAESLPQ
IQARFPTLALAEQPTREPSAFLRTFRALPVRLHAQAAAEVRVVVDQDLCGTTGQCVLT
LPGTFRQREPDGVAEVCMATVPQALHAAVRLAASQCPVAAIRVIESEAGDDHCTNPGP
TPSPADAERHAAKDLRNPGEHDGTI

115 Family

CYP115A1P   Bradyrhizobium japonicum
            GenEMBL L02323 L12971 U12678 (11,715bp see 1351-1578)
            NC_004463 complete genome 2317600..2317905
            Tully,R.E. and Keister,D.L.
            Cloning and mutagenesis of a cytochrome P-450 locus from
            Bradyrhizobium japonicum that is expressed anaerobically and
            symbiotically
            Appl. Environ. Microbiol. 59, 4136-4142 (1993)
            Note: called BJ-2 see CYP112, CYP114, CYP117
            Note: This gene fragment has a perfectly good P450 sequence 
            of 76 amino
            acids that includes the C-terminal up to a stop codon.
            This may be a fragment of another intact P450 that was 
            broken up or
            rearranged during cloning.  A pseudogene would be expected 
            to have lost
            integrity slowly and the whole gene should fade at about 
            the same rate.
            This fragment is good but no upstream region continues it.
GDADRFDVTRRHNPHLSFGQGPHFCLGAALARLELGCAFPAL
FVRLEHLALTIAAEDVVYMPSYVIRCPQRLPVTFRPSIA

CYP115A2v1  Mesorhizobium loti 
            GenPept NP_106680 88% to CYP115A1P 39% to 154C1 41% to 154A1 
  1 MPAAPTQLDR LSSAILRQGG MARVSLPGDV VTWAAARHQT LRQMLSDQRF NKDWRQWRAL
 61 QDGEIPEDHP LIGICKVDNM TTAHGADHRR LRGLLSSSFA PSRIALLAPR VEQCVDRLLA
121 EMAQRGGSAD LMSEFAAPLP TNVIAELFGL PDEQREEIVA LTYSLASTSA TAEEVRQTRQ
181 RIPEFFRRLI ALKRGQLGDD LASALIVARD KGELVSDTEL IDMLFMVLSA GFVTTAGVIG
241 NGVLALLTHP QQLHLVRSGQ VPWSQAIEEI LRWGTSAANL PFRYATQDVE IDGCLVRRGD
301 AVLMAFHAAN RDEKAFGPGA NRFDVTRRHN PHLSFGEGPH SCLGAALARL ELRCAFPPLF
361 GRLEDLALTI AAEDVVYMPS YVIRCPQRLP VSFRPSVA

CYP115A2v2  Mesorhizobium loti
            GenEMBL AL672113 41375..42607
            Strain R7A symbiosis island
            Gene = msi159
            10 DIFFS with CYP115A2v1

CYP115A3P   Rhizobium etli symbiotic plasmid p42d
            NC_004041 54883..55296
            70% to 115A1P 70% to 115A2
            gene = cpxP1 pseudogene C-terminal
ANSYGRPTYGDTDMFDFNRLQNPHLPLGQGPHLCLGAALARLELGSVFPPPFVRPEDLALAIAAE

116 Family

CYP116A1    Rhodococcus erythropolis
            GenEMBL U17130 (6458bp)
            Nagy,I., Schoofs,G., Compernolle,F., Proost,P., Vanderleyden,J. 
            And De Mot,R.
            Degradation of the thiocarbamate herbicide EPTC (S-ethyl
            dipropylcarbamothioate) and biosafening by Rhodococcus sp. NI86/21
            involve an inducible cytochrome P-450 system and aldehyde
            dehydrogenase.
            unpublished

CYP116A2    Saccharopolyspora erythraea NRRL23338
            SACE_4562, se: 5100284,5101570 (-) STRAND, 
            56% to CYP116A1, 53% to CYP116B1
VEELQVDATRVGAGCPISRIAEEFDPFGEAYQQDPAGVLKAAREREPVFYSPELDHWVVT
RYADIKEIFRDTRRFSASNALDPITPLGAKARERLAEYDFAPGPVLVNEDEPLHMRRRRA
LAGPLAADEVAKLEGRIRDLVTRYVDGFAGRGRADLVDDLLWEVPAIVGLLVCGVPDEDI
DRARHYTIKMGSFTWGRPTEEHQVEIADQVGQWWSLSGRLVERLKREGGEGWVPTAIEVH
REDPELVNDNHLQNMMMSGLVAAHETTTNATANALRHLLSNRSSWEALCADPSAIPNAVE
ECLRFSSSVLCWRRKALVDVPVGGVTIPAGARVLLVIGSGNHDDDVFGDPGELDIARSNA
KRHLTFGIGSHACIGAPLARLEMRIILEELTRRLPGMRLVEGQDFGYLRNASFHGPRHLL
VEWEPAGA 

CYP116B1    Ralstonia metallidurans
            GenEMBL NZ_AAAI01000322 
            25751..28093 gene = Reut3205
            52% to CYP116A1 with C-term. Extension
            extension may contain a reductase and a ferredoxin component
MPQTNAPASSGSCPIDHSALRAPNGCPISHQAAAFDPFEDGYQQ
DPPEYVRWSRAQEPVFYSPKLGYWVVTRYDDIKAIFRDNITFSPSIALEKITPTGEAA
NAVLASYGYAMNRTLVNEDEPAHMPRRRALMEPFTPAELAHHEPMVRKLTREYVDRFI
DTGRADLVDEMLWEVPLTVALHFLGVPEEDMDLLRQYSIAHTVNTWGRPKPEEQVAVA
HAVGNFWQLAGRILDKMREDPSGPGWMQYGLRKQRELPEVVTDSYLHSMMMAGIVAAH
ETTANASANAIKLLLQHPDVWREICEDPALIPNAVEECLRHNGSVAAWRRLVTRDTEV
GGMSLAAGSKLLIVTSSANHDEHHFADADLFDIHRDNASDQLTFGYGSHQCMGKNLAR
MEMQIFLEELTSRLPHMRLAGQRFTYVPNTSFRGPEHLWVEWDPARNPERTDPTVLAP
RDAVRIGEPTGGTTGRTLIVERVETAAQGVSRIRLVSPDGRALPRWSPGSHIDIECGH
TGISRQYSLCGDPADTSAFEIAVLREPESRGGSAWIHASLRAGDKLKVRGPRNHFRLD
ETCRRAIFIAGGIGVTPVSAMARRAKELGVDYTFHYCGRSRASMAMIDELRALHGDRV
RIHAADEGQRADLAQVLGAPDANTQIYACGPARMIEALEALCATWPEDSLRVEHFSSK
LGTLDPSREQPFAVELKDSGLTLEVPPDQTLLATLRAANIDVQSDCEEGLCGSCEVRV
LAGEIDHRDVVLTRGERDANNRMMACCSRAAKGGKIVLGL

CYP116B2   Rhodococcus sp. NCIMB 9784
           GenEMBL AF459424 
           66% to 116B1 over full fusion protein length
           extension may contain a reductase and a ferredoxin component
MSASVPASAPACPVDHAALAGGCPVSANAAAFDPFGSAYQTDPA
ESLRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNILFSPAIALEKITPVSAEATAT
LARYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESG
KADLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAV
GRFWQYAGTVLEKMRQDPSGHGWMPYGIRKQREMPDVVTDSYLHSMMMAGIVAAHETT
ANASANAFKLLLENRAVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATADTRIGDV
DIPAGAKLLVVNASANHDERHFERPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEM
QIFLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLHRHQ
PVTIGEPAARAVSRTVTVERLDRIADDVLRLVLRDAGGKTLPTWTPGAHIDLDLGALS
RQYSLCGAPDAPSYEIAVHLDPESRGGSRYIHEQLEVGSPLRMRGPRNHFALDPGAEH
YVFVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSE
EGTRIDLAALLAEPAPGVQIYACGPGRLLAGLEDASRNWPDGALHVEHFTSSLAALDP
DVEHAFDLELRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVAVLDGEVD
HRDTVLTKAERAANRQMMTCCSRACGDRLALRL

CYP116B3    Rhodococcus ruber
            GenEMBL AY957485 
            Liu,L., Urlacher,V.B. and Schmid,R.D.
            Cloning, expression, and characterization of a 
            self-sufficient cytochrome P450 monooxygenase from 
            Rhodococcus ruber DSM 44319
            Applied Microbiology and Biotechnology
            Published online: 11 April 2006 
            DOI: 10.1007/s00253-006-0355-0
            93% to CYP116B2 
MSASVPASACPVDHAALAGGCPVSTNAAAFDPFGPAYQADPAES
LRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNLVFSPAIALEKITPVSEEATATLA
RYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESGKA
DLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAVGR
FWQYAGTVLEKMRQDPSGHGWMPYGIRMQQQMPDVVTDSYLHSMMMAGIVAAHETTAN
ASANAFKLLLENRPVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATTDTRIGDVDI
PAGAKLLVVNASANHDERHFDRPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEMQI
FLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLQRQHPV
TIGEPSTRSVSRTVTVERLDRIVDDVLRVVLRAPAGNALPAWTPGAHIDVDLGALSRQ
YSLCGAPDAPTYEIAVLLDPESRGGSRYVHEQLRVGGSLRIRGPRNHFALDPDAEHYV
FVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSAEG
TRVDLAALLATPVSGTQIYACGPGRLLAGLEDASRHWPDGALHVEHFTSSLTALDPDV
EHAFDLDLRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVTVLEGEVDHR
DTVLTKAERAANRQMMTCCSRACGDRLTLRL

CYP116B4    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            73% to CYP116B3 Rhodococcus ruber

CYP116B5    Acinetobacter radioresistens
            No accession number
            Gianfranco Gilardi, Daniela Minerdi
            Submitted to nomencature committee July 25, 2012
            62% to CYP116B2 in P450 part

CYP116C1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha08932
            Submitted to nomenclature committee 12/13/04
            45% to CYP116A1, and 116B1, 53% to rha10704 CYP116C2 

CYP116C2    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha08932
            Submitted to nomenclature committee 12/13/04
            53% to rha08932 CYP116C1 

CYP116D1    Saccharopolyspora erythraea NRRL23338
            SACE_2622, se: 2849652,2850875 (+) STRAND
            39% to CYP116A1, 43% to 116A2 
            45% to CYP116C2
MHERFDPLATDYLADPFPILAAIREETPVFYSSELDMWPVTRHEDIKRIFTDYETFSGAI
TQTPVYPLAEEAKDILAAGFHTTPTVSNCDPPKHTRVRAHNVKAFSARRIAVLEPTIRAY
VTEMIDRILHQDRFDIVQEVTFPLPATIVFNLIGFPESDMEMLKGLAINRMAFTWGRSTE
AEQVRIAKNQVDYWQYCTEFVASRLAEPKDDFTSDLIRTHLADPDELSVDEITNVVHALS
FAGHETTTNVSSSMIQRLLTHREQWEELCADPALIPKAIEEGLRFDPSLFTWRRITTKPV
SIGGVEVPAGAKLLLLVGSANHDPAKFPDPEAFNIHRSGAQAHLTFGRGIHSCFGAPLAR
LEMQIMLEELTARMPGLRLVEDQDVQYHVNACFRGPVELWLDNSAHR 

117 Family

CYP117A1    Bradyrhizobium japonicum
            GenEMBL L02323 L12971 U12678 (11,715bp)
            NC_004463 complete genome 2321653..2322996
            Tully,R.E. and Keister,D.L.
            Cloning and mutagenesis of a cytochrome P-450 locus from
            Bradyrhizobium japonicum that is expressed anaerobically and
            symbiotically
            Appl. Environ. Microbiol. 59, 4136-4142 (1993)
            Note: called BJ-4 see CYP112, CYP114, CYP115P

CYP117A2    Rhizobium sp. NGR234 plasmid pNGR234a
            GenEMBL   AE000082 complement(7357..8700) U00090
            NC_000914 complement(229666..231009) gene = y4kV
            Freiberg,C., Fellay,R., Bairoch,A., Broughton,W.J., Rosenthal,A.
            and Perret,X.
            Molecular basis of symbiosis between Rhizobium and legumes
            Nature 387 (6631), 394-401 (1997)
            about 90% identical to 117A1
MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDG
GAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRD
ARAHAARTGLINDMVSAFDRSDDALSDDLLVANIRLLLLAGHDTTASTMAWMVIELAR
QPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPATTLLPRRALQELQL
GQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVC
IGYHLVWLELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS

CYP117A3    Mesorhizobium loti
            GenPept NP_106891
            NC_002678 complete genome 5191629..5192972
            locus_tag = mlr6367
            94% to 117A2
  1 MDMLLNPLDR RHRLRDDIPV VPGAFPLVGH LPAIVCDLPR LLRRAERTLG SHFWLDFGPA
 61 GHLMTCVDPD AFALLRHKDV SSALIEEIAP ELLGGTLVAQ DGGAHRQARD AIKAAFLPKG
121 LTQAGIGNLF APVIQARVQA WRDRGDVTIL RETGDLMLKL IFSLMGIPAQ DLPGWHRKYR
181 QLLQLIVAPP VDLPGLPLRR GRAARDWIDA QLRQFVRDAR AHAARTGLIN DMVSSFDRGD
241 DALSDDVLVA NIRLLLLAGH DTTASTMAWM VIELARQPGL WDALVEEAQR VGAVPTRHAD
301 LAQCPVAEAL FRETLRVHPA TTLLPRRALQ ELQLGQRRIP AGTPLCIPLL HFSTSALLHE
361 APDQFRLARW LQRTEPIRPV DMLQFGTGPH VCIGYHLVWL EMVQFCIALA LTMHKAGVRP
421 RLLSAVEKGR RYFPTAHPSM KIRIGFS

CYP117A3v2  Mesorhizobium loti
            GenEMBL AL672112 complement(81551..82888)
            Strain R7A symbiosis island
            Gene = msi068
            2 DIFFS with CYP117A3v1

CYP117A4   Rhizobium etli symbiotic plasmid p42d
           NC_004041 59081..60424
           85% to 117A2
           gene = cpxP4
MDMLLNPLNRWRRLRDDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCLDPDALALLRHKEVSSALIEEMAPDILGGTLVTLDG
SAHRQARDGIKAAFLPRGLTEAGIGELFEPIIRAQVKAWRDRGEVAILPDTRNLMLKL
TFSLMGIPAQDLSEWHRKYRQLLQLMVAPPIDLPGMPLRRGRAARDWIDAQSRQFIRD
ARARAARTGLINDMVSAFDCSDGALSDDVLVANIRLLLLAGHETSASTIAWMVIELAQ
HPELWDALVEEAQRVGAVPTGHEDLAQCPVAEALFRETLRMHPASSLVPRRAMQELQL
GQRRIPSGTHLCIPLLHFSTSPLLHEAPDQFRLGRWLQRTEPIRPVDMLQFGAGPHVC
MGYHLVWLELVQFSIALALTMQEAGVRPRLMSGVEKGRRYYPTAHPSMTVRIGFS

>CYP117B1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_5081
            41% to 117A3

118 Family

CYP118P1    Mycobacterium leprae
            GenEMBL L04666 (40,123bp)
            Smith,D.R.
            M. leprae cosmid dna sequence
            Unpublished (1992)
            Note 15,700 to 17,350 is the region of interest

CYP118P1    Mycobacterium leprae
            GenPept CAC31116                 
            NC_002677 547312..547788 locus_tag = ML0447
            NC_002677 complement(2562932..2563627) locus_tag = ML2159 
            (a duplication of the seq.)
            putative fatty oxidation complex alpha subunit 
            Sequence below is from TIGR primary nucleotide sequence for ML2159
            CYP118 exact match, 49% to 102C1
  4 TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH 183
184 DIAAQTRREIYQNRSDRGIANVSY
258 FGDVVKLRCLRRVVDATLRLWS
    VPCYLRQARRD 360
361 TTLGNGTSLFHKGQWVIVLLTAPMPG
    WGPDANEFNPDRXXXXXXXXXXXXXXXX 470
520 FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG 
    YCLSISEAFTLKTVGL 677

CYP118P1/CYP102 PSEUDOGENE Mycobacterium leprae 
        Combined from fragments 50% TO 102C1
        Probable CYP102 pseudogene
RLGSGIVEQRISVLSIIALADPXXXXXXXDETVWENI
XXXXXXRLLMGDELFTXXXXESNWGKAHN 
TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH
DIAAQTRREIYQNRSDRGIANVSY
FGDVVKLRCLRRVVDATLRLWS
VPCYLRQARRD
TTLGNGTSLFHKGQWVIVLLTAPMPG
WGPDANEFNPDRVLPEICRKLPYTYIL
FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG 
YCLSISEAFTLKTVGL

119 Family

CYP119A1   Sulfolobus acidocaldarius (formerly solfataricus) (an archaebacterium)
           CORRECTION: Sulfolobus acidocaldarius (see Rabe et al. 2008)
           GenEMBL U51337 (1254bp)
           Wright, R.L., Harris, K., Solow, B., White, R.H. and Kennelly, P.J.
           Cloning of a potential cytochrome P450 from the Archaeon Sulfolobus 
           solfataricus.
           FEBS. Lett. 384, 235-239 (1996)
           Kersten S. Rabe, Kathrin Kiko, and Christof M. Niemeyer
           Characterization of the Peroxidase Activityof CYP119, a
           Thermostable P450 From Sulfolobus acidocaldarius
           ChemBioChem 2008, 9, 420 - 425
           DOI: 10.1002/cbic.200700450


CYP119A2   Sulfolobus tokodaii
           GenPept BAB66184                 
           64% to CYP119A1 U51337 Sulfolobus solfataricus
  1 MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL EMLRSGKVFF
 61 DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV TVKLLSELDE EFDVIESFAI
121 PLPILVISKM LGINPDVKKV KDWSDLVALR LGRADEIFSI GRKYLELISF SKKELDSRKG
181 KEIVDLTGKI ANSNLSELEK EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA
241 LKAVEEALRF SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP
301 DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID NEVLNGYRKL
361 VVRVERA

120 Family

CYP120A1    Synechocystis sp. (strain PCC6803) Cyanobacterium
            GenEMBL   D64003(113064bp)
            coding region 62160-63494
            Kaneko,T., Tanaka,A., Sato,S., Kotani,H., Sazuka,T., Miyajima,N.,
            Sugiura,M. and Tabata,S.
            Sequence analysis of the genome of the unicellular cyanobacterium
            Synechocystis sp. strain PCC6803. I. sequence features in the 1Mb
            region from map positions 64% to 92% of the genome
            DNA Res. 2,153-166 (1995)
            note: gene slr0574 (previously had incorrect gene identifier here)

NT01NS3472 Nostoc sp. PCC 7120 in TIGR not in Genbank
40% to CYP120 aa 399-443
MEMKIVAAHLLRRYHWEILPNQSLDSVLVPTNQPQDGLRVRFQPL

CYP120A2   Trichodesmium erythraeum
           NZ_AABK02000021 
           complement(1844..2800) gene = Tery2088
           318aa (short) 57% to 120A1 (missing N-term 127aa)
MTANYLEKWVEMGTLTWYPEIRNYTFDIASLLFMGSDESSQTKL
VSLFEEWVKGLFSIPLSLPWTRFGKSLRCRQKLLQHIEEIILQRQQQQNLGEDALGIL
LQAQDKEVNGLSLDELKDQILLLLFAGHETLTSAIASFCLLTSQHLDVLTRLRQEQKQ
FSAIEPLTLENLKRMTYLDMVLKEVLRLIPPVGGGFRQVTQDCEFCGYSIPKGWLVQY
QIAKTHQDETLYPDDKNFDPERFAPENAVDKQKVFGYVPFGGGMRECLGKEFARLEMK
IFAVMLLRGYEWELLPEQDLSVVAAPTPYPRDGLKVKFRKVE

CYP120A3    Cyanothece sp. CCY0110
            ZP_01730375.1
            54% to CYP120A1
MLIFFFYNKSKLIYNFDQKMTNIESQKSVSLPPGETGLPFIGETLSFLFDPDFAKKKKSKYGQIYKTNIF
GNDTVTMIGAEANQFLFRNENKYVVSTWPKSTRVLLGKLSLAVKDGNFHTSRRKLLAQAFQPRALNSYIP
KMTEITQQYVEKWLQTKELTWYPELRKYTFDVACSLLISIDNASQTKLASDFETWCQGLFTLPINLPWTN
FGKALKCRAKLLQEIETIIINRQQQPKHQNDALGILLEAKDEEGNSLTIEELKDQILLLLFAGHETLTSS
LSSFVLLMAQHPNILEKVRTEQENLNITEDITSEKLKEMTYLEEVLKEVLRFIPPVGGGFRKVIEEFEFQ
GYRIPKDWTVQYQIAQTHKESDIFPDYQTFDPERFSPENMADKQKNFGYIPFGGGLRECLGKEFARLEMK
IFASVLVHNCHWQLLPDQDLEMITIPSPRPRDGLKVKITEV 

CYP120A4    Lyngbya sp. PCC 8106
            ZP_01619745.1
            53% to CYP120A1
MTTSEKKQSYPTPPGSLGLPLIGETLSFLRDRDFATKRHQKYGSVFKTNIFGNPTIMMIGTEANQFIFTN
EKKYFENSWPPSTTALLGPASLTIQTGDIHKSRRKLLAQAFQPRVLAGYVPTMEIMTRRYLQKWEQQKTF
AWYPELRKYTFDVACKLFVGDEKASETEMGEWFETWCQGLFTLPLRLPGTKFNKALNCRKKLLNQIETII
RQRQQQAEPGEDALGLLLQAKDEDGNSLSVEELKDQILTLLFAGHETLTSSVTAFCFLLAQHPDVLAKAR
LEQQQIQLTEPLSFEQLKLMSYLDQVLKEVLRFIPPVGGAFREVIETCEFNGYTFPKGWTVLYQIGKTHQ
DNSIYNQPEKFDPDRFSPERTEEKPYGYIPFGGGMRECLGKEFAKLEMKVLATMLLREYEWELLPNQNLE
MTVSPTPHPKDELLVNFKRLSEVH 

CYP120A5    Nodularia spumigena CCY941
            ZP_01628555.1
            53% to CYP120A1
METTNSQTQNKLPLPPGNLGLPLIGETISFLRDPEFAEQRYQQYGPIFKTHLFGQPTIMMIGAEANRFLF
SNENQNFTISWPDSTKTLLGPASLALQTGGTHQKRRKLLSQAFQPRALAGYTSKMEEITHNYLHKWQRMG
TFKWYPELRNYTFDVACKLLIGTDAASDSHFGELFEEWCAGLFTIPINLPWTKFGRALRCRQQLLVKIEE
IILQRQQQPHSDADALGLLLQAEDEDGNRLSLAELKDQVLLLLFAGHETLTSAIASFCLQLAQHPEVLAQ
ALAEQQQLAIEESLTLEHLKQMQYLDQVLKEVLRTIPPVGGGFRRVIQSSEFNGYQIPEGWSVLYQIGKT
HQDSSTYTEPESFDPQRFAPERVEDKQKPFGYVPFGGGVRECLGKEFAKLEMKLFAALLIREYHWELVPG
QNLDLIMVPTPHPRDDLQVNFSTQRGAEGSAKVRGVLDLGGEVAM 

CYP120A6    Synechococcus sp.PCC7002
            ORF00071
            53% to CYP120A1
MTSPSELPLPPGKFGLPVIGETIEFFTDRNFQKKRLEKYGDVFKTSIFTKPTVVMVGAEA
NEVLFRNENKYVKATWPKSTRILLGADSLATQEGGIHSSRRRIIFQAFQPRALESYIPTI
EKITQRYLTQWEQKQEFAWYDELRKYTFDVASTLFIGKDGGAETPLANLFEEWVKGLFSL
PINLPWTAFGKAMKCRRKLLRELEMIIGDRLKTYDANAEPTDALDLLIRAKDEDGNSLSI
DELKDQILLLLFAGHETLTSSLVSFGLLVGQHRDVFEKIRAEQDALDIGNGLDMAVLQQM
TYLDQVFKEVLRLVPPVGGGFREVINTFEYKNFQIPQGWAVQYQIAQTHKDEALYPDHEK
FDPERFSPERLADKQKKFGFIPFGGGMRECIGKEFARLEAKILASMLARDYDWELLPDQD
LSMQVIPTPLPKDGLQIRFYRRQESSSTTA 

CYP120B1   Nostoc punctiforme
           NZ_AAAY02000018.1 
           complement(62382..63695) gene = Npun4299
           43% TO CYP120A1
MKTNQIPPGSFGLPVLGETLSFVFDRDFAKKRYHQYGPIFKTHL
LGRPTVVMAGPEALEFVLSSHIENFSWREGWPDNFKTLLGESLFLQDGEEHRRNRRLM
MPALHGPALASYFSTMEDITRSYLQKWEKKQEFTWFQEFKQLTFDIASQLFLGTRPGP
ECVRLSQLFTTLTNGLLAINPLPLPFTTFGKAIAARNEILEHLTQVVRERQQNPTQDT
ISLLIKAKDEDGNSLSEKEIIAQAVLLLFAGHETTTSMLTWLCTELACHPEVLEKARV
EQLQLASQGDLDLEQLGKMPYLEQVLWEVERLHQPVGGGFRGVIKDFELNGYHVPTGW
QLYYSIGVTHQIEEIYSEPELFDPDRFSPQRQEHKKYPFSLVGFGGGPRICIGIAFAK
MEMKIVAAHLLRSYHWEILPNQSLEVVAVPTNRPKDGLRVRFQPR

CYP120C1   Nostoc punctiforme
           NZ_AAAY02000127.1 GenPept ZP_00106106.1
           8154-9512 gene = Npun477
           44% to 120B1 36% to CYP120A1
MQQLKSAEEIPGSYGLPILGETLEIFRDSELYLWRRFQQYGSVF
KTSVLGRKRAYLIGPSANRLVLVEQAENMSSRIGWYFLESTFGNNILLQDGEEHRLTR
RLMYPAFHGKAIATYFDTIQNIVQDFLKDWGERGTISLNSSFRQLTLMIATRLFLGSQ
NKSEVEQTSQWFTQLLDSSMAIFKWNVPFTLYGRGQNARGKLVAFLREAIAQRIEQGN
LEESKDVLGLLLAAVDEDGNKLSETQVINEALLLLFAGHETTASLLTWVIFELGNHPE
WRERLRQEQLAVVGNNPLSLSHLKQFPQLTNVLKEAERLYPPVYAYNRGVLKDIEYGG
YRIPAGWFVTISPMLTHRLPELYTEPDRFDPDRFAPPREEDKKHPLALMGFGYGSHSC
LGMEFAQMEMKIVLSTLLRHYDWTVKPDYSAIAPVRQPSKVKDILQAYIEPLLIKHPL
DS

CYP120D1    Cyanothece sp. CCY0110
            ZP_01732300.1
            48% to CYP120A1
MLFGNSSISVQVGEIHKQRRQILYEVFKPRMLDSYFNTMVKITEKYLDYWMKQENIVWYPEIENYTFDLA
FKFLIGLDKASESSFKPLYEQWQKGIFSLNTIKLPWTKFGKAWKARNLLKKELKEIIIKRQKEQEANDSD
ALDILIKAKDEDGKQLLVDEISDHLLNILFAGYGTLTSTLASFCRLMAQEGEILGKIREEQQRFPKQLTI
MQLKEMPYLDLVLKELLRTNTPVGTGFRQTINNCEINGYHIPKNWFIFYQISNTHKDTDIYQDPDVFDPD
RFGLDRAEGEKPFSYLPFGGGIRECLGKDFARLEMKIFSSLLVRKCQWDLLPNQNLEIEFTPVAKPKDGL
KVKISSY

CYP120E1    Trichodesmium erythraeum IMS101
            YP_722428 
MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVYQKYGPVYKTNFLGKNFIYFQGYEAIK
FILTNENKYFTYSQILRNYQRIFGENDITVLAGKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKW
IKSDYVDLYSEINNYTLDMILKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFN
QFEQIIVRRKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTSEHLD
VLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDCSFQGFRIPKGWHAYYY
ISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGGARECIGKEFAYLVIKIFISALLDNCSWK
FKENQDLTINTFPVARPAHKIEVCFTPK

121 Family

CYP121A1   Mycobacterium tuberculosis
           GenEMBL Z77163 (42861bp) gi 1449344 Rv2276
           complement (32358 to 33548)
           unpublished

CYP121A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome 2526703..2527893
           Gene = cyp121 100% match
           locus_tag = Mb2299

122 Family

CYP122A1   Streptomyces sp.
           GenEMBL U65940( 2500bp)
           nearly identical to rapJ gene of St. hygroscopicus involved in 
           rapamycin biosynthesis

CYP122A2   Streptomyces hygroscopicus
           GenEMBL X86780 (107379bp)
           coding region 96465-97625
           rapJ

CYP122A3   Streptomyces hygroscopicus var. 
           GenEMBL AF235504 CDS 71460..72626 
           gene="fkbD"
           note="C9 hydroxylase" 89% to 122A1 77% to 122A2

123 Family

CYP123A1   Mycobacterium tuberculosis
           GenEMBL Z80226 (34809bp) gi 1550644 Rv0766c
           complement (8322-9530)

CYP123A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome complement(861053..862261)
           Gene = cyp123 100% match
           locus_tag = Mb0789c

CYP123A2   Mycobacterium smegmatis 
           MSMEG5826 TIGR 
           pksS
           75% to CYP123A1
           75% to CYP123A4 Mycobacterium vanbaalenii 
           40% to CYP275B9
           41% to CYP275B6 MSMEG3700
MSLPTVEPVLDPYDYDFHEDPYPYYKRLRDEAPLYRNDERNFWALSRHED
VLKGFRNSTALSNKHGVSLDPVSRNDEAHRVMSFLALDDPAHLRLRTLVS
KGFTPRRIRELEARVTEIAVQHLEIALQSDSFDFVDDFAGKLPMDVISEL
MGVPEEDRVRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRR
RRNVSDDLTSALVEAEIDGDKLTDDEIMAFLFLMVVAGNETTTKLLANAA
YWGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGT
TVPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLG
AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR

CYP123A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4930
           72% to 123A1

CYP123A3   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 123A3 M. marinum = ortholog

CYP123A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01207533.1, EAS23092.1 
           71% to 123A1
MTISEVRLDPYNYDFHEDPYPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDPA SRGPHASKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTEIAVTHLDAMLEQATTGDAVDYVDEF AGKLPMDVISELMGVPDADRVQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTDDL TSALLEAEIDGDRLTDDEIIGFMFLMVIAGNETTTKLLANAAFWGHRNPDQLTSVYQDLARVPLWVEETL RFDTSSQILARTVSGELTLYDTTIPDGDVVLLLPGSAHRDERVFENPDDYVIGREIGSKLMSFGSGAHFC LGAHLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR

CYP123A5    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05833 and Rha05832
            Submitted to nomenclature committee 12/13/04
            61% to CYP123A1
            formerly CYP123A2 but this was already assigned to
            a Mycobacterium smegmatis seq (my error)

CYP123A6    Rhodococcus sp. R04
            No accession number
            Rui Xue
            Submitted to nomenclature committee 5/30/11
            77% to CYP123A5 but CYP123A5 has an 
            error in the I-helix region

CYP123B1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4833
           45% to 123A1

CYP123B2   Mycobacterium vanbaalenii PYR-1 
           ZP_01203471.1,EAS24463.1 
           72% to 123B1
MVSVQIRYDPFDASILNDPYPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPTPP GSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAI LPAAVIADLLGVPATDRDQFRLWSSQLVQVDVNHGQTTDALAAAAAIYAYFTDFLADRRKNPREDLMSAL ANATVDGIGLTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDS PAQGLSRTLTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSEHQVAFGRGIHFCLGAAL ARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV

124 Family

CYP124A1   Mycobacterium tuberculosis
           GenEMBL Z77163 (42861bp) gi 1449354 Rv2266
           complement (39907-41193)

CYP124A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome 2519058..2520344
           Gene = cyp124 100% match
           locus_tag = Mb2289

CYP124A1   Mycobacterium avium subsp. paratuberculosis str k10
           GenEMBL AE017234.1
           85% to 124A1 (ortholog)
MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRD
GAFATLRREAPISFWPAIEMDGFVAGNGYWALTKHEDVHFASRHPEIFSSVPNITIND
QTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERARRLVSSLVANH
PNGEAELVSELAGPLPLQVICDMMGIPEEDHQRVFHWTNVILGFGDPDLATDFEEFLQ
VSMDIGAYATALAEDRRVNHHDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETT
RNAISHGVLALSRYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRG
TKMKAGDKVALWYNSANRDESTFGNPWLFDVARTPNPHLGFGGGGAHFCLGANLARRE
IRVVFDELRHEIPDIVATEEPARLLSQFIHGIKRLPVAWTPPR

CYP124A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3361
           85% to 124A1 (ortholog)

CYP124A1   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 124A1 M. marinum = ortholog

CYP124A1   Mycobacterium smegmatis 
           MSMEG3551  TIGR 
           74% to CYP124A1 M. tuberculosis
           44% to CYP268A3
           80% to CYP124A1 Mycobacterium vanbaalenii
           44% to CYP142B1 Mycobacterium vanbaalenii
           note: TIGR seq has 25 extra aa at N-term (lower case).  
           These my not be real. They do not match other 124A sequences.
           formerly 124A2, but all of the CYP124A appear to be orthologs
mpcstadrisagippvgaaalypgg
MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAPISF
HPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIVIGDQTPEL
AEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDSVRDRARRLVAGMV
DRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQIFHWTNVILGFGDP
DLTTDFDEFVTVAMDIGAYATALADQRRSAPADDLTTSLVQAEVDGERLT
SAEVASFFILLVVAGNETTRNAISHGVLALTRYPEQRRLWWSRFDELAPT
AVEEIVRWASPVSYMRRTVTRDTELAGTALPAGSKVTLWYGSANRDETKF
DNPWMFDVQRHPNPHVGFGGGGAHFCLGANLARREITVLFSELHRHLPDI
VATEEPDRLQSAFIHGIKRLPVAWR

CYP124A1   Mycobacterium vanbaalenii PYR-1 
           ZP_01209134.1,EAS21395.1 
           72% to 124A1 M. tuberculosis (ortholog)
MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDNEV AGHWALTRHDDVFYASRHPEIFSSALGITVGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAL IEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDPDIA TDFDEFVSVAMGIGAYATQLADDRRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAI SHGVLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA NRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAF 
IHGIKRLPVSWSA

CYP124B1   Streptomyces cinnamonensis
           GenEMBL AF440781 93981..95273
           polyether antibiotic monensin biosynthesis gene cluster
           41% to CYP124
           gene = monD
MGLTVGPDNAKRGIVPITDSKPAATFPDLVDPSFWARPHAERVA
LFEEMRGLPRPAFIRQNMPGVPWTFGYHALVKYADIVEVSRRPQDFSSNGATTIIGLP
PELDEYYGSMINMDNPEHSRLRRIVSRSFGRNMIPEFEAVATRTARRIIDELIARGPG
DFIRPVAAEMPIAVLSDMMGIPAEDHDFLFDRSNTIVGPLDPDYVPDRADSERAVIEA
SRELGDYIAGLRAERLAAPGNDLITKLVQVQADGEQLTRQELVSFFILLVIAGMETTR
NAISHALVLLTEHPEQKQLLLSDFDTHAPNAVEEILRVSTPINWMRRVATRDCDMNGH
RFRRGDRIFLFYWSGNRDESVFPDPYRFDITRGTNAHVTFGAVGPHVCLGAHLARMEI
TVLYRELLAALPQIHAVGQPRRLDSSFIEGIKHLHCAF

CYP124B2   Streptomyces nanchangensis NS3226
           GenEMBL AF521085 complement(100196..101467)
           polyether ionophore nanchangmycin biosynthetic gene cluster
           41% to CYP124
           gene = nanP
MNRGVVSPTEATPASSAKATRPPDFMDPSFWLRPRDERAEVFEK
LRALPGPEFVPPRLPWGPLASGYYALSKHADICEVSRRPQDFSSEGATAILPPEMDEF
YGSMINMDNPEHSRLRRIVARSFGRGMAPKFDAMSRRVARRIVDELIERGPGDFIRPA
AEMPIAVLSTMMGIPGEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDY
IGRLREDRLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQAL
VLLTEHPDQRQLLLSDFELHAKGAVEEILRVGTPINWMRRTATGDCEMNGHRFRKGDE
IFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFCLGAHLARIEIIAMLREL
LASLPDIRVEGEPVRLASSFIEGFKELSCTF

CYP124B2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_3705 
           99% to CYP124B2 Streptomyces nanchangensis NS3226 only 3 aa diffs

CYP124C1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha04649
            Submitted to nomenclature committee 12/13/04
            Borderline CYP124

CYP124D1X   Mycobacterium avium subsp. paratuberculosis str. k10
            GenEMBL AE017241, NP_962752.1, AE016958.1 4266449-4267744
            69% to ZP_01204629 CYP124D2 Mycobacterium vanbaalenii
            48% to 124E1
            renamed CYP125F1 based on clustering on a tree
MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY
RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD
APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE
CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ
YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG
ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER
VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV
LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA

CYP124D2X  Mycobacterium vanbaalenii PYR-1 
           ZP_01204629.1, EAS25621.1 
           83% to CYP124D3
           renamed CYP125F2 based on clustering on a tree
MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA

CYP124D3X  Mycobacterium flavescens PYR-GCK
           ZP_01194022.1, EAS09632.1
           83% to CYP124D2
           renamed CYP125F3 based on clustering on a tree
MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT
GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG
YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR
HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD
IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF
FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT
ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG
ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA

CYP124E1X   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_7184
            49% to 124D1, 48% to 124D3
            44% to 124A1 and 124A2
            renamed CYP125E1 based on clustering on a tree

CYP124F1   Frankia alni ACN14a
           YP_713586.1
           CAJ62021.1
           49% to CYP124A1 Mycobacterium avium subsp. paratuberculosis
MSLIADVDLDDLDWWTRPAAERDAYFASVRASGERPYFPELDLAGNTRGRGFYAVTRYADVMEVSRRPED
FCSGEGTNIFDQPLDLREFFGSIIAMDNPQHARQRRIISRGFTAKNLEALRANVGEVTREVLATVAEKGE
CDFVTEVAALIPLRIVNDMMGIPRSQEQFIFESTNKLLGASDPEYVPDQSPRGVAKNLSRVGDDFAELLR
ELAADRQRNPGDDLISLLVAAEGENLTAQELASFFILLVGAGNETTRNAIAHGLLALTQNPDQRALWASD
VDGLTPTAVDEVVRWASPVLHMRRTVTADGVRLGDQEFREGDKLVLWYRSANQDESVFPDGTRFDVRRDL
TPPHLGFGAPGPHFCLGAHLARLELSVVFKALFEYLPDIHAVEEPQFLRTNFLHGIKHLKAAYTPTTVRA

CYP124F2   Frankia alni ACN14a
           YP_715440.1
           CAJ63908.1
           46% to CYP124A1 Mycobacterium avium subsp. paratuberculosis
MPGTRGLPGDVLDDLSWWTRPAAERDATFAWLRAHDPRPYVPELDLTGAPRGGGFWALTRLDDVREVSRR
PADFCSGQGSLIFDQPPRLREFRGSIIDMDNPEHARQRRIVARGFTPKAVAALVEDIARTSREVISAVAR
RGECDFVTEVAALLPLRIVNNLLGIPRSEERFLFEQTNILMGASDPEYVPDQTPRSVARAVHGAGQAMSG
LLEELARDRIRNPQDDLVSSLVAAQEEENLTPTELATFFNLLVGAGNETTRNALAHGLSALTRFPDQREL
WRSDLDRYTPGAVEELLRWASPVLYMRRTVARDGVTLGEQRFDAGDKVVLWYRSANQDEAYFDDATAFRV
TRDPNPHVTFGAPGPHHCLGANLARVELAIAFRTLFELLPDIEATAEPDLLRSNFLHGVKHLPARFTPTA
PRP

CYP124G1    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR529
            42% to CYP124B1

125 Family

CYP125A1   Mycobacterium tuberculosis
           GenEMBL Z82098 (34154bp) gi 1666115 Rv3545c also AD000003
           coding region 8135-9436

CYP125A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome complement(3927359..3928660)
           Gene = cyp125A1 100% match
           locus_tag =Mb3575c

CYP125A2   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV5841 57% to CYP125A1 from Mycobacterium tuberculosis

CYP125A3   Mycobacterium smegmatis
           MSMEG5951 TIGR
           75% to CYP125A1
           58% to CYP125A2 67% to CYP125A4 54% to CYP125A5
           90% to CYP125A9  Mycobacterium vanbaalenii
           70% to CYP125A10 Mycobacterium vanbaalenii
           56% to CYP125A11 Mycobacterium vanbaalenii
MPTPNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGD
KGYWLVTKHADVKEVSRRSDVFGSSPDGAIPVWPQDMTREAVDLQRAVLL
NMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAAQGAGDFV
EQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSS
FELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAV
AGNETTRNSITHGMIAFAQNPDQWELYKKERPETAADEIVRWATPVSAFQ
RTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHV
GFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNG
IKHWQVDYTGAGKASVSGAPGTCPVAH

CYP125A4   Mycobacterium smegmatis
           MSMEG3526 TIGR 
           73% to CYP125A1
           67% to CYP125A3, 58% to CYP125A5P 57% to 125A2
           77% to CYP125A10 Mycobacterium vanbaalenii
           67% to Cyp125A9  Mycobacterium vanbaalenii
           59% to Cyp125A11 Mycobacterium vanbaalenii
MSDSALHLPAGFDFTDPDIYAERLPVDELAELRRVAPIWWNAQPIGAGGF
DDGGFWVVTKHKDVKEISLRSDVFSSLEKTALPRYPEGTVQDQIEQGRFV
LLNMDAPHHTHLRKIISRAFTPRAVERLRDDLAERARAIVRAAAEEGSGD
FVEQVACELPLQAIAGLMGVPQEDRRKLFDWSNQMVGNQDPEFVANDGAS
AAVELITYGMQLAAQRAAAPGDDLVTKLVQADVEGHKLSDDEFGFFVVLL
AVAGNETTRNSITQGMMAFTDHRDQWELFKRERPVTTADEIVRWATPVTS
FQRTALADTEVSGVRIKKGQRVVMFYRSANFDEDVFTDPYRFDILRDPNP
HVGFGGTGAHYCIGANLARMTIDLIFNAIADEMPDLTPISEPVRLRSGWL
NGIKHWQVDYRGDAAKHRAAQASSQADR

CYP125A5P   Mycobacterium smegmatis
            MSMEG5819 TIGR
58% to Msmeg_CYPXXXIV  56% to CYP125
54% to MSMEG5951, 56% to 125A1, 58% to MSMEG3526, 54% to MSMEG5951
80% to CYP125A9  Mycobacterium vanbaalenii
59% to CYP125A10 Mycobacterium vanbaalenii
55% to CYP125A11 Mycobacterium vanbaalenii
MATMNTCPFGNGYDFTDPDVLFRGIPVEEFAVLRKTAPVWWNQQGESIFDDGG
YWVISRHEDIKTISRDGGEVWSTNAKGAVMRLPDGVTAEQLDLTKALLIN
HDAPEHTRLRKLVSRLFTPRSVAALEEKLAVAAHDIVAEAKAEGSGNFVE
DIAMKLPLLAIADLIGVPEADREKIFAWSNAIINTDDPDFDSDPTVANAE
LMGYAYTMAEERRRCPADDIVTRLVQADVSGESLGEVEFAFFVILLAVAG
NETTRNAITHGMNAFFENPDQWELFKRERPITAVDEIVRWATPVHCFQRT
AVVDTEIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGF
GGNGAHYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVK
DLQVSYRG*PARLIYYSRMRTHGWSGSAPATD 

CYP125A6   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2783
           74% to 125A1

CYP125A6P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 125A6 M. marinum = ortholog
           disrupted by insertion sequence and chromosomal inversion

CYP125A7   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM5032
           90% to 125A1

CYP125A7   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 125A7 M. marinum = ortholog

CYP125A8   Streptomyces scabies
           SCAB65311
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           84% to CYP125A2

CYP125A9   Mycobacterium vanbaalenii PYR-1 
           ZP_01208885.1, EAS21554.1 
           74% to 125A1
MPGPNSCPISPEFDFLDASLNLERLPVEELAELRKSEPVHWVDVPGGTGGFGDRGYWLVTKHADVKEVSK HNEIFGSSPDGAIPVWPQEMTREAIDLQKAVLLNMDAPQHTRLRKIISRGFTPRAVGRLEDELRARAQRI AATAATEGSGDFVEQVSCELPLQAIAELLGVPQEDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELITYA MKMAEERAKNPTEDIVTKLIEADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFSRNPDQWELY KKERPETAADEIVRWATPVSAFQRTALEDTELGGVQIKKGQRVVMSYRSANFDEEVFENPHSFDIMRNPN PHVGFGGTGAHYCIGANLAKMTINLMFNAIADAMPDLKPIGDPERLKSGWLNGIKHWQVDYTGQCPVQH

CYP125A10   Mycobacterium vanbaalenii PYR-1 
            ZP_01209149.1, EAS21410.1 
            71% to 125A1 
MATPTLPPGFDFTDPDLNLERLPVEELAELRRCAPIWWNEQTSGGAGPFGDGGYWVVTKHRDVKEISKHS EVFSSQQKTALPRYPEGSTTEQVETGSLVLLNMDAPRHTHLRKIISRGFTPRAVERLREDLAQRAHNIAK SAAAAGAGDFVEQVSCELPLQAIAGLLGVPLEDRKKLFDWSNQMVSDDDPEFAHYDNRNAATELIMYAMQ LAALRAEQPGEDIVTKLIEADVDGHKLTDDEFGFFMVLLAVAGNETTRNSITHGMIAFTEHPDQWELFKR ERPATAVDEIVRWATPVTSFQRTALRDYELSGVQIKKGQRVVMSYRSANFDEEVFDDPFTFDIMRDPNPH VGFGGTGAHYCIGANLARMTIDLMFNAIADHLPDLSSAGTPDRLRSGWLNGIKHWQVDYTGPSGCPVAH

CYP125A11   Mycobacterium vanbaalenii PYR-1 
            ZP_01207525.1, EAS23084.1 
            57% to 125A1 
MTATQSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTAPVWWNEQADSIFDDGGYWVISRHEDVKAISRN STQWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEDRLADAAREIV RSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFHWTNAIMNTDDPEFDADPTMANAELMGYAYS MAEERRRCPADDIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDNPAQWELFKR ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPH LAFGGNGAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR

CYP125A12P  Mycobacterium leprae
           GenPept CAC30983
           NC_002677 2415021..2416227
           locus_tag="ML2024
           Sequence below is from TIGR primary nucleotide sequence for ML2024
           51% to CYP125A1 Rv3545c Z82098 Mycobacterium tuberculosis
   1 PGFDFPDPEIYTEQLSV*EPAEMCQAETI**NEQPIGRSGFYDDDY 138
     XXXXXXXXXXXXXX
 174 HSGTFSNLEKTALACYQEGMNDEQISRGKLVLLNIDASQYTRLHKIISPGFIP*AAEQLR 353
 354 DDLXXXXXXXXXXXXXXX 362 
 410 SGDFVEHVSCELSRQAAIAGLPSG 481
 480 VPQEDCKKLFHWSN 521
 522 QTVGAQDPKFATNDPMVTSVKLIM*AMQIAADRAKPLGQVIVTNLVEADIEGHKLSKDEFGSF 710 
 713 VIMLTAAGKENTRNCIMQSMMQFTNFPD*WELYK 814 
 816 KKAPGTTADKIIRQATLVMS 875
 876 FQRTVLK*YELSSVSIKKGQRVVVIYRSANFDEKVLTIRLPCSIMRNPT 1022
1022 PHAGFNDTNVHYCIGIN 1072
1073 LARMTIDRMFHAIAESMPNL*STGKPK*LRSGWLNGVKHWQVD 1201

CYP125A13  Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           75% to 125A2 before frameshifted region
           clone name SP0266
           formerly 125A4 but this name was already assigned to 
           an M. smegmatis sequence (my error)

CYP125A14P  Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05823
            Submitted to nomenclature committee 12/13/04
            67% to 125A1 
            formerly 125A5P but this name was already assigned to 
            an M. smegmatis sequence (my error)

CYP125A15    Salinispora tropica (marine actinomycete)
             Strop_2612 complement(2932913..2934139)
             66% TO CYP125A14P    Rhodococcus sp.
             58% to CYP125A1 Rv3545c Z82098 Mycobacterium tuberculosis
             60% to CYP125A2 SAV5841 AP005044 Streptomyces avermitilis
MTEPRIPVGFDFTDPAVLERRVPREEFAELRRTAPVWWNVQPRGSAGFDDDGYWVVTRYA
DVMAVSRDSDTYSTRENTAIARFQPGTTRADLEMQRVIMLNVDPPEHTKLRAIVSRGFTP
RAINALRGSLAERAERIVRDAAVRGTGDFVADVACELPLQAIAELIGVPQHHRRKVFDWS
NQLIGYDDPAYGVDPLTAAAELLAYAMEMANERQLNPSDDLVTKLVNAQIDGEHLTTDEF
GFFVMLLAVAGNETTRNAITHGMLAFLEHPEQWELFKAERPRSAVEEIIRWATPVNVFQR
TALVDTTLGGQAISAGQRVALFYGSANFDESVFEEPERFDITRSPNPHLGFGGSGAHFCL
GANLARLEIELIFHSIADHMPDIRKVAEPRRLRSGWINGIREMPVRYR

CYP125A16  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1118 
           79% to CYP125A2 Streptomyces avermitilis

CYP125A17   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2554 79% to CYP125A2

CYP125A18   Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            76% to CYP125A14P Rhodococcus sp. RHA1
            note: formerly CYP125A17 but name conflict with another P450 

CYP125A19   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR5169
            78% to CYP125A2

CYP125B1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05835
            Submitted to nomenclature committee 12/13/04
            48% to 125D1 44% to 125A5, 44% to 125A2

CYP125B2    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            76% to CYP125B1 Rhodococcus sp. RHA1

CYP125C1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha04272
            Submitted to nomenclature committee 12/13/04
            47% to 125D1, 44% to 125B1 

CYP125D1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05286
            Submitted to nomenclature committee 12/13/04
            48% to 125B1, 47% to 125C1 

CYP125E1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_7184
            49% to 124D1, 48% to 124D3
            44% to 124A1 and 124A2
            renamed CYP125E1 based on clustering on a tree
            formerly CYP124E1

CYP125F1    Mycobacterium avium subsp. paratuberculosis str. k10
            GenEMBL AE017241, NP_962752.1, AE016958.1 4266449-4267744
            69% to ZP_01204629 CYP124D2 Mycobacterium vanbaalenii
            48% to 124E1
            renamed CYP125F1 based on clustering on a tree
            formerly CYP124D1
MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY
RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD
APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE
CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ
YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG
ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER
VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV
LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA

CYP125F2   Mycobacterium vanbaalenii PYR-1 
           ZP_01204629.1, EAS25621.1 
           83% to CYP124D3
           renamed CYP125F2 based on clustering on a tree
           formerly CYP124D2
MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA

CYP125F3   Mycobacterium flavescens PYR-GCK
           ZP_01194022.1, EAS09632.1
           83% to CYP124D2
           renamed CYP125F3 based on clustering on a tree
           formerly CYP124D3
MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT
GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG
YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR
HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD
IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF
FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT
ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG
ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA

CYP125G1    Salinispora tropica (marine actinomycete)
            Strop_2786 complement(3187819..3189087)
            46% TO 125C1 Rhodococcus sp. 45% to 125B1 Rhodococcus sp.
            44% to 125E1 Sorangium cellulosum
            42% to CYP180A1 SAV2165_geoC AP005029 Streptomyces avermitilis
MSTEVVSTGNRADIAHPATYAAGVPYAEFARLRRDKPVSWVPEAALWRRSGEGRILSQGP
GFWAVTTHEGVVAASRQPEVFSSGRQGAFLADPRTTADLEQARQLLVNMDAPQHARVRKL
VTAVFTPRAIRALGDSVTAHARNLVERAVRQEECDVVADLAAELPLLVLADLLGLPREDR
HLLYQWSNNLVGFDDPEYGGGDVEAYRKTFFEAFQYALSVAGERRRAPREDLMTLLATSE
VDGRRLTDREFCNFWLLLVVAGNETTRHLITGSVLALVDNPMQRERLVADDTLLPSAVDE
LLRWVSPIMQFRRTAIVDTELCGTPIAAGDKVVLWYTSANRDAAVFEAPDELRLHRNPNP
HLSFGMGPHFCLGAHLARLEARTMLRELAPHLSRFRLTGPVVRLESNFVNGVKSLPGSFT
GQ

126 Family

CYP126A1   Mycobacterium tuberculosis
           GenEMBL Z80226 (34809bp) gi 1550656 Rv0778
           coding region 20888-22132

CYP126A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome 873620..874864
           Gene = cyp126 100% match
           locus_tag = Mb0801

CYP126A2   Mycobacterium smegmatis
           MSMEG5812 TIGR
           78% to CYP126A1
           78% to CYP126A4 Mycobacterium vanbaalenii
           44% to CYP124D2 Mycobacterium vanbaalenii
           42% to CYP162A
MRADLTDLDNFADGFPHALFEAHRREAPVYWHEPTEHTPDGEGFWSVATY
AETLAVLRDPVTFSSVTGGSRPYGGTLLQDLAIAGQVLNMMDDPRHAQIR
RLVSSGLTPRMIARVEEDLRVRARRLLDAVEPGVPLDFLVEVAAELPMQM
ICILLGVPESERHWLFHAIEPQFDFSGSRTASVGQLTPEEAGNRMYRYGM
ELIAAKRAAPTDDMLSVVANAHDAELSDLELYLFFSLLFSAGAETTRNAV
AGGLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVE
LGGCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFGQGVHY
CLGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA

CYP126A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4915
           79% to 126A1

CYP126A3   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 126A3 M. marinum = ortholog

CYP126A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01207518.1, EAS23077.1
           74% to 126A1
MRVAGALAAVDFTDLDNFAAGFPHGLFALHREQAPVYWHEPTENTPDGEGFWSVATHAETLAVFRDPETY SSVTGGERAFGGTLLQDLPIAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLRERARRLLDEVEPG TPVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIEPSFDFGGARKASITRLSVEEAGSRMFEYGQELI AAKRAQPGDDMLSVVVNSGDPQLSDLESYLFFNLLFSAGAETTRNAIAGGLLALIENPDAYRALRADPGL LPTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLG FGQGVHYCLGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR

CYP126A5P  Mycobacterium leprae
           GenPept CAC31567       
           NC_002677 complement(1384839..1385327)
           locus_tag="ML1185
           Sequence below is from TIGR primary nucleotide sequence for ML1185
           37% to CYP126 C-terminal
184 DRSLIPSAIEEGSRSETPNWASVTRITIA*LAIGGKTILPNAGVDILMGSANRDGSRWTE 363
364 PNTFDIHWPRQAHTTLAGSHMCLGIGLAQLDTRVMLNNLFD 486

CYP126B1    Saccharopolyspora erythraea NRRL23338
            SACE_4143, 4612821,4614128 (-) STRAND, 
            46% to 126A2 44% to 126A1
VTVDQPELPTSRNASESVSDQLPAVLGGFDLTDQVRFSGGFPHEVFNRLRADEPILLHPP
GRTRDGESFWVLSRYEDVVEAAANPVFSSQGGGSREGGGTHLDDLPAGTYAGGMLNMMDD
PRHQLIKDIVSPAVCPSAVAALEPVVRERASALVSTVLERGTCDLQAEVAGRYSVEVVAA
LLGVPRQDWSRLVDWAEIAMGYEDRDEGEATGRSQAALLDMYKYGCELVRAKRAEPAGDF
MSLIATGEIPEGHGQAPLVDYEREVFFNLISLAGTEPTRNAIAIGLLALVEHPEQWQALR
ADRSLLDGAVEEALRWSSPTPYNRRTATEDIRFRDVLIREGDKVTLWWASANRDERVFAD
PFRFDVRRSPNPHLAFGHGAHTCLGPALARMELRVLLEELLDRVERIELTGPVPWARNSK
HTVALRVPVALTASS 

127 Family

CYP127A1   Rhizobium sp.
           GenEMBL Z68203(34010bp) 
           coding region 29431-30675
           also AE000101 Rhizobium sp. NGR234

CYP127A2   Rhizobium sp. BR816
           No accession number
           Ellen Luyten
           Submitted to nomenclature committee 4/12/2000
           73% identical to CYP127A1

CYP127A3v1 Mesorhizobium loti
           GenPept NP_106463
           NC_002678 complete genome 4745586..4746803
           79% to 127A2
  1 MAINPVPDHV PPEMVRDFSL FTSPGMPPTP NGDPHAAVAC AHDGPPIFYS PYNTQDGRGT
 61 WVITRAADQR KVLQDTETFS SHRSIFSSIL GETWPTIPLE LDPPAHGAFR SLLSPLLSPK
121 RVTALEPAVR ERAIALIDRI TASATSCDVM KDFAFPFTVS IFLRFLGLPD QGLDTFVGWA
181 KDLLHGDDVE RPVAARKIVA FIDELATNRR KDPVDDLMTF IVQAQIEGRR LTDGEIRGIG
241 VLVFVAGLDT VAAAIGFDLA YLARNLKDQE LLRSEPARIL LATEELLRAY PPIQLIRVAT
301 KDIDFEGAPI RKGDYVSCAT MIANRDPEEF ESPNTVDLAR DHNRHAAFGY GPHRCLGSHL
361 ARREIVIGLE EWLARIPTFR IKEGTAPITC GGHVFGIENL ILDWS

CYP127A3v2  Mesorhizobium loti
            GenEMBL AL672114 complement(100678..101895)
            Strain R7A symbiosis island
            Gene = msi332
            2 DIFFS with CYP127A3v1

CYP127A4   Rhizobium etli symbiotic plasmid p42d
           NC_004041 97484..98974
           81% to 127A2
           gene = cpxA5
MHLCSERIYRKRGTRENPMSTGRAGEASKKFRLRPTKQRGFRAA
RRSDRCIACHWRLALLRLEIWRSTILLAPSPRRIRSRRRGFDDRRKAVATIRVPEHVP
PEMVKDFSLFTSPGMERMPNGDPHAAVACLHNGPRIFYSPCNTRDGRGTWVIVRAQDQ
RKLLQDTGTFSSHRSLFASALGENWPLIPLELDPPAHSVFRSLLNPLLSPRRIMELEP
AVRDRAIALISKISASSTSCDILTDFAFPFAVSIFLRLLGLSDERLNTFVGWGKDLLH
GDGIRRTAAARTILAFIDELAAMRRKEPADDFMTFVVQAKVDGRLLRDQEIHGIGVLL
FVAGLDTVATAIGFDLAYLARNPTEQELLRSKPDRIVLAAEELLRAYSTVQMIRVATK
DINFEGAPIRKGDYISCATMIANRDPVEFENPNTIDLAREDNRHTAFAYGPHRCLGSH
LARREIIIGLEEWLSRIPDFRIKDGTAPITYGGHVFGMENLILDWS

128 Family

CYP128A1   Mycobacterium tuberculosis
           GenEMBL Z77163 (42861bp) gi 1449352 Rv2268c
           coding region 37021-38490

CYP128A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome complement(2521761..2523230)
           Gene = cyp128 100% match
           locus_tag = Mb2291c

129 Family

CYP129A1       Steptomyces sp.
          GenEMBL U50973(3196bp)
          Dickens,M.L. and Strohl,W.R.
          Isolation and characterization of a gene from Streptomyces sp.
          strain C5 that confers the ability to convert daunomycin to
          doxorubicin on Streptomyces lividans TK24
          J. Bacteriol. 178, 3389-3395 (1996)
          gene name doxA

CYP129A2   Streptomyces peucetius 
           GenEMBL U77891 CDS comp (83..1330)
           gene="doxA"
           product="daunorubicin C-14 hydroxylase" 94% to 129A1 

130 Family

CYP130A1   Mycobacterium tuberculosis
           GenEMBL Z77137 (36096bp) gi 1480330 Rv1256c
           coding region 30691-31908 cy50.26

CYP130A1X  Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome
           CYP130 lies in a deletion in M. bovis

CYP130A2   Mycobacterium smegmatis
           MSMEG5026 TIGR
           77% to CYP130A1
MSHPAVAFELANADTWADPWDMYTALRDHDPVHHVVPPERPHHDYF
VLSRHADIWAAARDHETYSSAQGLTVNYGELELIGLADNPPFVMQDPPTH
TEFRKLVSRGFTPRQVEAVEPQVREFVVERLERLRAEGGGDIVAELFKPL
PSMVVAHYLGVPEADRAQFDGWTEAIVAANSEAGSALGAGDAVMSMTGYF
AELIERRRREPGDDTISHLVAAGADDEAVDVLSILAFTFTMVTGGNDTTT
GMLGGAVQLLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATR
DVTIGDTTIPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSH
GAHFCLGAAAARMQSRVALTELLTRCPDFTVDLDAVVWAGGSYVRRPLSV
PFRAGA

CYP130A3    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha08652
            Submitted to nomenclature committee 12/13/04
            69% to 130A1 

CYP130A4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4184
           86% to 130A1

CYP130A4P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 130A4 M. marinum = ortholog

CYP130A5   Mycobacterium vanbaalenii PYR-1 
           ZP_01208620.1, EAS21834.1 
           78% to 130A1  
MTAVLSHGSPVHFALADASTWADPWPMYRALRDHDPVHHVVPEDRPNHDYYVLSRHADIWAAARDHQTFS SALGLTVNYGELDLIGLADNPPMVMQDPPVHTEFRKLVARGFTPRQVEAVEPKVHDFVVDRIEHLRANGG GDIVAELFKPLPSMVVAHYLGVPDEDRGKFDGWTDAIVAANTSAGGLGGALDTLGDALGEMMSYFTALIE RRRTEPEDDTISHLVAAGVGADGDISGVLSILAFTFTMVTGGNDTTTGMLGGSVQLLHRRPDQRTMLAEN PDLIPDAVDEFLRLTSPVQMLGRTVTHDVTIGDVTIPEGRRVMFLYGSGNRDERQYGDDAGELDVTRKPR NILTFSHGAHHCLGAAAARMQSRVALTELLTRIPDFEVDESGIAWAGGSYVRRPVSVPFTVTH

CYP130A6P   Mycobacterium leprae strain TN
            GenPept AL583920.1
            59% to CYP130A1
VMSHRFRFTTADIWPNPWSMYRTLRDHEAVHHVVPANQPEDDYYVLPRHADVWSMAMRS
HAKLSSAQRLTVNYSDMELIGLQDNPPMVMQDQPV*TKCRKLVSRRFTPRQTNVVEPKVR
HFVVEHIEQLRAKGSVDIVTELFKPLPPMVVAHYFGFPEKVRSQFDGW
TTAADGGGALFRFPRKSPITIRRLAPAIVAANTADAGGITNELDVAGYAVESMLAYFTR
IATGGNNTVTGMLGG*MPL
SHRRKQHRHWHARRLDAVKDTAEAD
LLRLTSSVRGLMRTTTRDVAIGHTTVSPGRRVLMRYGQAKRDER*YSAAAS*LDVTW*
PPNILIFSHGAH
YLGAKVTRMQRR
VRLTELLARYPDFEVDESSIAWAGGKLHTTP

131 Family

CYP131A1       Streptomyces peucetius
         GenEMBL L47164(3444bp)
         coding region 32-1348
         gene dnrQ  duanosamine biosynthesis
         possible sequence errors at C-terminal (no recognizable signature sequence 
         in the last 68 amino acids)

CYP131A2     Streptomyces sp.
         GenEMBL L35154 (4134bp)
         3838-4134 N-terminal fragment 94% identical to L47164
         gene dauQ daunomycin biosynthesis 

132 Family

CYP132A1  Mycobacterium tuberculosis
          GenEMBL Z80108 (40778bp) gi 1542902 Rv1394c
          complement (9842-11227)
          most often matches CYP4 family in blast search

CYP132A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome complement(1566263..1567648)
           Gene = cyp132 1 aa diff
           locus_tag = Mb1429c

133 Family

CYP133A1     Erwinia herbicola
           Randy S. Fischer, Roy A. Jensen
           First P450 from an enteric bacteria (similar to E. coli)
           submitted to nomenclature committee

CYP133B1v1     Xylella fastidiosa, section 35 of 22. 
               AE003889 CDS complement(3751..4959)
               82% to AE003887 48% to CYP133A1

CYP133B1v1   Xylella fastidiosa 9a5c 
             GenPept AAF83187                 
             100% match
  1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYMES
 61 MRVRYGDSAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG IAVSKIAKVF DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

CYP133B1v2  Xylella fastidiosa Temecula1
            GenPept AAO29526                 
            6 diffs to CYP133B1v1
  1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYIES
 61 IRLRYGDTAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG MAVSKIAKVL DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

CYP133B1v3 Xylella fastidiosa Dixon
           NZ_AAAL01000071 complement(6849..8057)
           98% to 133B1v1 7 diffs 97% TO 133B1v2 11 diffs 
           gene = XfasA0474
MKLTDLSNPAILENPYPLYETLRAQAPFVSIGPNALMTGRYSLV
DSLLHNRNMGKNYMESMRVRYGDSAADMPLFQAFNRMFITINPPAHTHLRGLVMQAFT
GRESESMRPLVIDTAHQLIDNFEQKPSVDLVAEFAFPFPMQIICKMMDVDIGDAVTLG
MAVSKIAKVFDPSPMSADELVHASTAYEELAQYFTKLIELRRTHPGTDLISMFLRAEE
DGEKLTHDEIVSNVIMLLIAGYETTSNMIGNALIALHRHPEQLTLLKSDLSLMPQAVS
ECLRYDGSVQFTMRAAMDDIEVEGELVPRGTVVFLMLGAANRDPAQFTHPDQLDITRK
QGRLQSFGAGIHHCLGYRLALIELECALTALFERLPHLRLAHLDALNWNQRSNLRGVN
TLIVDLHAKN

CYP133B2v1  Xylella fastidiosa, section 33 of 22 
            AE003887 CDS 6723..7925
            82% to AE003889 48% to CYP133A1

CYP133B2v2  Xylella fastidiosa Ann-1
            NZ_AAAM01000051 complement(2764..3966)
            97% TO 133B2v1 8 diffs
            gene = XfasO1476
MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLATDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLS
VAVSNIAKVFDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLSGYETASNMIGNALIALHRHPKQLARLKSDLSLMPQTVL
ECLRYDGSVQFTVRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP

CYP133B2v3  Xylella fastidiosa Dixon
            NZ_AAAL01000066 complement(2275..3477)
            97% TO 133B2v1 9 diffs 10 diffs to CYP133B2v2
            gene = XfasA0420
MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLAIDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMHVDISDAISLS
VAVSNLAKVLDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAVL
ECLRYDGSVQFTIRAAIDDVSIEGDVVPRGTIVFLMLGAANRDPVQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP

CYP133B3   Xanthomonas axonopodis pv. citri str. 306
           GenPept AAM38014                 
           56% to 133B2
  1 MLLSDLATPQ FRHDPYPTYA RLREEGPLVQ VADGRLMSGR YAVVDRLLSD RRVGRDYLQS
 61 VRLRYGEAAV HLPLFQGMSR MFLLLNPPLH TQLRGLMTQA FGARQMESMR EVASDIAAGL
121 IDAFQANGHC DLLTEFAFPL PIAIICRMLD IAAADVTALS HATSALAKVF DPMMTAEELQ
181 ATSVAYDQLA TYFHGVIAQR RSAGGDDLIA RFIQAEDNGR RLSEEEIVSN VILLFFAGHE
241 TTSNMICNAL VALHRHPQQL RLLQETPGLL PNAVLECMRY DSSVQMATRT ALQDFEIEGV
301 AVPRGTMLYL MLGAANHDTL QFTDPQVLDI RRQQGRALSL GGGIHHCLGN RLALIEVEAA
361 LACLLARLPA LRLEQLDTLS WNDRANLRGV DALLASW

CYP133B4   Xanthomonas campestris pv. Campestris str. ATCC 33913
           GenPept AAM42318                
           BioI biotin synthesis
           52% to 133B2 65% to 133B3
  1 MQLSDFATPA FRQDPYPMYA RLRAAGPLVQ ISDNGWVSGH YTVVDALLSD RRVGRNYLDS
 61 IRVRYGANAA EMPLFQGMSR MFLLLNPPVH TQQRALMTKA FGARQLEALR EVAVDTADAL
121 LDQHEDRRSC DLLNDFAMPM TISLICRMLG LAVTDVAALG QASSALAKVF DPLMRPEDMA
181 QATAAYTTLE QYFRAIVLQR RDTQEDDLIA RLIAAEDHGQ RMPVDDIVSN VIMLFTAGHE
241 TTANMICNAL IALHRHPEQL QLLRDTPTLM PNAVLECMRY DSSVQVAMRS VLQPLQVEGT
301 TLPVGAILYL MLGSANHDAE QFTAPQQLDL RRQQGRALSF GGGVHHCLGN RLALIELETA
361 LERLLQRAPA LRLPELDNLS WNERANLRGI QALHATW

CYP133B5   Ralstonia solanacearum GMI1000 megaplasmid
           GenEMBL AL646080 77388..78584
           gene = RSp0709
           77% to CYP133B2v2
MKLADLSTPSFLENPYPLYETLRSQGPFVRIGPNALMTGHYSIV
DALLHNRQMGKSYMESIRLRYGDEGPNMPLFQGFSRMFLMLNPPMHTRLRGLMMQVFN
ARQIESMREVATATAHQLIDDFEQKPSADLVAEFAFPLPVRIICQMMDLDIDDAMALG
VGVSKLAKVFDPAPMSADALVETSAAYEELAQYFTKVIEARRAQPGTDLISMLMRAEE
NGETLTHDEIVSNVILLFIAGHETTSNMIGNALIALHRNPQQLDLLKREPSRMPNAVL
ECLRYDGSVQVTIRAALEDVEVEGEVLPRGTTVFLMLGAANRDPAQFTDPDQLDIGRQ
QGRLQTFGAGIHHCLGYRLALIELESALGALFERLPNLRLTNLDQLSWNQRGNLRGVN
ALMAAW

CYP134A1   Bacillus subtilis
           GenEMBL AF017113, Z99121, Z99122
           cypB also called cypX

CYP134A2P  Bacillus cereus ATCC 14579
           GenPept AAP10061   
           57% to CYP134A1 cypX Z99122 Bacillus subtilis C-term
 1 MIGATNCDSN VFERPDKFNV YRPDIDIKKA FSGTARHLAF GLSIYNCVGV AFAKLKIEID
61 STIKDNISRK KLRDIKDFVK KTSKMN

CYP134B1   Photorhabdus luminescens subsp. laumondii TTO1
           GenEMBL NC_005126 complete genome complement(313663..314886)
           locus_tag = plu0296
           46% to CYP134A1
MAKLSSFNIHDPKFIKNPYDFYDILHKQDLVYFEQSQNSYFIGK
YEDVDAILKSSIFNTKPLTALAEPVMGDRVLAQMEGEEHACKRKFIMQGLSRDYFNRY
YEPMIRKITEDLLQPYMEKGNIDIVNDFGRDYAVLVTLSILGLPSDNYRDIAEWHKGI
ASFITQFDQTELEKMHSLECSQKLIRLLKPIIDQRRRNPSKDIISIFCQDTAMSMSEI
TALCLNILLAATEPADKILAMMLNHLISNPSMLDVVLKDRSLVRDAFEETLRLTSPVQ
LIPREASEDVTISGIDIPKGAVVFCMIGAANRDPSVFHKPNEFDLYRRKNTTSPQKAN
RKRHLAFGAGTHACAAAAFSLSQLEVSSNIILDLLHNLRFADHYHYQETGVYTRGPSK
LLLSFDPIASSAIKE

CYP135A1    Mycobacterium tuberculosis
            GenEMBL Z96800
            Rv0327c

CYP135A1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome complement(393726..395075)
            Gene = cyp135A1 1 aa diff
            locus_tag = Mb0334c

CYP135B1    Mycobacterium tuberculosis
            GenEMBL AL021942
            Rv0568

CYP135B1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome 660693..662111
            Gene = cyp135B1 100% match
            locus_tag = Mb0583

CYP135B2   Mycobacterium smegmatis
           68% to 135B1
MSTPGTLPPGPPLPAFVQTAMMLRHWSRFVSACRRRYGDVFTLRIASMGT 
WVYLADPADIKTVFAGDPTVFHAGEANSMLSGLLGETSVLVIDEDVHRDR 
RRLMLAPFARDAVARQTGVMAEVAATNIASWPVGTPFPVAPKMAEIALEV 
ILRTVIGATEPARLAALRHVMPQLLGIGPWQSLAIASPGLQRRRPWRTLQ 
RNLAEADRLLYAEIAACRAGPDLASRPDALAMLVRAANDEGRTMTDRELR 
DQLMTLLVAGHETTATGLSWTLERLIRHPAVLDKAVAAARTTDGSGEAYL 
DAVVRESLRIRPVVFEAGRVLTEPVELGGYLLPAGTLVAPSIGLVHASAD 
VYPDPDRFEPDRMLASTQAPSTWLPFGGGNRRCLGATFALVEMRVVLREI 
LHRVDLFATTARGEKQRLKHVTMIPHRGGRICVRALRDVAPAPMTCPAEA 
RRA 

CYP135B3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4483
           71% to 135B1

CYP135B4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0938
           75% to 135B1

CYP135B5   Mycobacterium vanbaalenii PYR-1 
           ZP_01204401.1, EAS25393.1 
           73% to 135B1
MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLRCGPRFVAACRRRYGSAFTLRVASMGTLVYLT DPADIKTVFAGDPDIYHAGEANSMLKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAA DNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGPWETLAIANQDLLRRRP WRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVRAGDMSDKELRDQLITLLVAGHDTTATALSW ALERLTRHPAVLAKAVRAARDGDDDYLDAVAKETLRDRPVVFDVGRVLKAPVELAGYRLPAGVMVIPGLV AVHADSQIYPHADRFDPDRMLGATLSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARG 
EHRRLKHVIFVPHRGARIRVRAKRVVAAEAPKCPMSGPA

CYP135B6   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2978
           64% to 135B1
           formerly CYP135B2 but that name was already assigned
           to a Mycobacterium smegmatis sequence (my error).

CYP136A1    Mycobacterium tuberculosis
            GenEMBL Z83866
            coding region 23158-24636
            Rv3059

CYP136A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome 3376038..3377516
           Gene = cyp136 1 aa diff
           locus_tag = Mb3085

CYP136A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM1634
           86% to 136A1
           note name change from 136A2 since all
           CYP136As seem to be orthologs

CYP136A1   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 136A2 M. marinum = ortholog
           note name change from 136A2 since all
           CYP136As seem to be orthologs

CYP136A1   Mycobacterium smegmatis
           MSMEG0997 TIGR
           MSMEG2291 TIGR
           65% to CYP136A1 M. tub.
           88% to ZP_01203885.1 Mycobacterium vanbaalenii
           note name change from 136A2 since all
           CYP136As seem to be orthologs
MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP 
AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS 
SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR 
RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD 
IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ 
ARKTLEDYFLSRIDEKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMIF 
LMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEKL 
ETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINHR 
LPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLEI 
KTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR

CYP136A1   Mycobacterium vanbaalenii PYR-1 
           ZP_01203885.1, EAS24877.1 
           65% to 136A1 M. tub
MPSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPPAGSDLKPILGDAGLPIIGHMI EIFRGGPDFILEIYRKHGPVYFAESPALSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLL DFDEHMFHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLDIASEVFMGVPA GTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIKARKTLEDYFSSRIGEKRRSESTDMFSVLCHS ADEDGQSFTDDQIVSHMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEKLE TYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINHRLPELWTDPEKFDPERFAEPRS EHKKHRYAFAPFGGGAHKCIGMVFGQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLR PLH

CYP136B1   Mycobacterium smegmatis
           MSMEG1160 TIGR 
           43% to 136A1, 42% to 136D1
MTIPAAEAAADAKVRLQTAVAGITARYPSREHALAAPPPGSGLKPV
MGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVGFRVALLMGPE
ALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRDHRRIMQQAF
TRSALNGYLDLMRPGIDRTVRSWPAAQRFPFYTSVKHLLLDQAAEVFIGA
ELGPEADQLSRDFHDTVCGGQAVIRADVPGGVWSRGLRARRRLERYFAGQ
LPARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNHMIFLLMAAHDTSAIA
ISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDLDSAYPLLDAAFKESL
RMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGVYASMRLADWWPEPDEF
DPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQFANMNVKAIMLHLLRHF
RWHVPAGYQPRMTWGTGPTPADGLPITLERLSA

CYP136B2   Mycobacterium flavescens PYR-GCK
           ZP_01192884.1, EAS10792.1 
           78% to MSMEG1160 CYP136B1
MSALPQSLPG LPAASAKLRF QSAAASVTSR YPSRVRPLSR PPAGSGLKPV LGNYGFPVLG
HHLSTFVEPL EFARERYERF GPVSWAGGIG FRVVQLMGPE ALETAWINRD KAFSSTRGWA
PVIGPFFHRG IMLLDFEEHR DHRRIMQQAF TRSALDGYLT LMRPGISRTV TSWPTAAGFP
FYTAIKKLLL DQAAEVFVGA VLGAEADRLS SDFHDTVCGG QAMIRADVPG GTWARGLRAR
ERLERYFAAQ IPDRRAGTGA DLFSMMCRSR SEDGDSFSDA DIVNHMIFLL MAAHDTSAIA
ISMLVYELGR NLRWQDALRD EADAGDGLGL ADLDGAYPLL DAAFKEILRM YAPAGTLFRQ
TVTDTEVCGH YIPRRTQVAI NVYASLRLAD WWPDPDRFDP GRFLGGGDAA AVHRYAFAPF
GGGVHKCIGQ QFADMNVKLV MHQLLRQFRW RVAPGYRPLM TWGTGPTPAD GLPISLQRLSGG

CYP136B3   Mycobacterium sp. KMS
           ZP_01282080.1 
           72% to MSMEG1160 CYP136B1
MTALTAQLTS PANTHRLQVA GAALTSRFPS REEPLATPPP GSNLKPVMGN YGFPFLGHTL
SALAEPLDFA RRRYDMYGPV SWAGGVGFRV VALMGPDALE TAWINRDKVF SSTRGWAPVI
GPFFHRGIML LDFEEHRDHR RIMQQAFART ALDGYLELMR PGIDRTLGGW PASDAFPFYP
SIKHLLLEQA AEVFVGTHLG PESDQLSADF HDTVRGGQAL LRADVPGGVW ARGLRARKRL
ERYFGDQIAD RQRGDGADLF SMLCRSEDDD GARFTPADIV NHMIFLLMAA HDTTAIALSM
LVYELGRNQK WQKTLRDEAV GRPNDAPAVG DLDAYPLLDA AFKEILRMYA PAGTLFRQTT
RDTDILGHFV PAKTQVAINV HASMRLADWW PDPDTFDPAR FIDQPGARAA VSRYAFAPFG
GGAHKCIGQQ FADMTVKTTM HQMLRRFEWS VADGYRIPLT WGTGPTPADD LPITLRTLTT

CYP136B4   Nocardia farcinica IFM 10152
           YP_117347.1, BAD55983.1 
           54% to MSMEG1160 CYP136B1
MVEITRSVAK GFGMSLQLPT TVSAVSDNAR HLRTRLSWQA QRAGLQVVKR YPTRIRPLAE
PPPGSGLKPV LGDFGPPGIG YTLHTLADPM GFSRERFERL GPVSWLGVLG RPVVSVAGPE
AFEEVLLDRD KVYSAQRGWE WLIGPFFHGG VMLRDFDDHM FHRRILQQAF TRPRLHGYQD
LTSPLLRRGI ESWRPAAEFH IHTAIKQLLL QQATEVFAGA ELGRESVALA HAFEDAVHGG
TAMVRANVPG GVWARGLRGR RRLEDYFRRE LPAKRAGEGN DLFSVLSRAT TEEGHTFTDE
EVVQHMIFVM LAAHDTSTIA SSMLVYELGR HPEWQDKLRA EAIGLGKESV GYDDLDELPL
LDMAFKEALR MYAPVAQQAR ETIADTALCG HYLPRGTLVM CGPYMMMRTA RYWRDPDEFD
PERFAPERRE DKSHRFAWAP FGGGAHKCIG LYFGGMTVKA VLYQMLTRFR WSVRPGYEPL
LVAGTGPTPA DGLPIRLERL AR

CYP136C1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha02367
            Submitted to nomenclature committee 12/13/04
            48% to 136D1, 74% to 136C2

CYP136C2    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha06567
            Submitted to nomenclature committee 12/13/04
            49% to 136D1

CYP136C3    Frankia sp. CcI3
            YP_481755.1
            ABD12026.1
            not like Frankia alni P450s 
            53% to CYP136C1 Rhodococcus sp. RHA1
MAVRGSRGPVPGDGGPPLVGYTLRYLHDPAQHWRQRYDRYGPVSWERTFGLRVVSLLGPDATGLALRNHE
QAFANGPGQQRIAGPFFRRGLSMLDFDEHRHHRRILAGAFAPDRLRGYLAGMNPSIERGVAGWRPGARFQ
VYPAVKQLTLELATRIFMGERLGPEADRFNAALFACIRAPGAVVRVPAPGLRWSRGLAGRRYLEEFLRLR
VPAKRAGSGTDMFSRLCHAEAEDGSRLSDDDVVNHMILMMVAAHDTSTITMTSMSYYLARHPEWQQRCRE
ESLALGTPAVDHADLDRLPSLALVMKEALRLVTPVPILLRATVKDIDVLGVTVPAGTVAALALAFTHQMP
EYWPSPERFDPERFADHRREDKVHPYAWQPFGGGPHTCIGLHFAGQQVKAILHQMLLRYRWSLAPGYRIS
LDRFPLPVPRDGLPVQLEKIT

CYP136C4    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            84% to CYP136C2 Rhodococcus sp. RHA1

CYP136C5P   Rhodococcus sp. R04
            AFAQ01002075.1 47570-47776 (-) strand
            Riu Xue
            Submitted to nomenclature committee Feb. 28, 2012
            73% to CYP136C2 Rhodococcus sp. RHA1

CYP136C5P   Rhodococcus pyridinivorans AK37
            AHBW01000043.1 60959-61165 (+)
            2 aa diffs to CYP136C5P Rhodococcus sp. R04

CYP136D1    Mycobacterium abscessus
            GenPept AAN38721 
            46% to CYP136A1
            name change from 136B1
  1 MDAVEAAQRP GGTMTNHLLA PAHHVKERLS SVIMVPAPHA VDDRWRRWSR DWPVRELAPA
 61 PAGSGLKAVR GDAGLPFVGH TLDYIRFGSD FSRERYDRLG SVSWMGAFGT KMVVIAGPDA
121 TREAFTSEAK AFSQDGWSFL IDAFFHRGLM LMSFDEHLMH RRIMQEAFTR PRLTGYVEQV
181 TPCVRSAVPA WPVGPSVRIY PLLKELTLDI ATDVFMGGRG KDESDAVNKA FVATVRAASS
241 LVRAPLPGTR FRAGVQGRRV LEDYFFRHLP AARAGETEDL FAALCQATTE DGERFSDEDV
301 VNHMIFLMMA AHDTSTITTT AVTYFLAKYP QWQEAAAAEA AAIGDGLPDI EALEKMTVID
361 RVIKEALRLL APVPLVMRKT VRDVAIDGYH IPSNTLCAIT PAVNHFDRTI WNDPERFDPS
421 RFDEPRREDQ HHRFAWVPFG GGAHKCIGMQ FGTLEVKAIL HRMLRSFTWK VPENYHVRWD
481 NTSLPIPVDG LPLEMKRR

CYP136D2   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3315
           85% to 136D1
           name change from 136B2

CYP137A1    Mycobacterium tuberculosis
            GenEMBL AL022121
            Rv3685c

CYP137A1   Mycobacterium bovis subsp. bovis AF2122/97, 
           NC_002945 complete genome complement(4064642..4066072)
           Gene = cyp137 1 aa diff
           locus_tag = Mb3710c

CYP137A2   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM5175
           83% to 137A1

CYP137A2P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           100% to 137A2 M. marinum = ortholog except for insertion 
           and one stop codon

CYP137A3   Mycobacterium vanbaalenii PYR-1 
           ZP_01208503.1, EAS22069.1 
           61% TO CYP137 Rv3685c AL022121 Mycobacterium tuberculosis
MAEHSPHESYRCEMVHIVRPPSLPAPPPLAPVFGGLYAAAFGMGGQAIVAQMVRRYGPVVALPVLGFGKV VAVADAALAKQVFTENPDVLLGGEGVGPAAAIYGPRSMFVLEEPGHLRRRRLLTPPLHGELLGSYVPIIE SSTRSAMATWPVGRPMRMLDAARELTLDVIVQVVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRR FGALRRWGRLSDANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRDDLITLVLA GHETTATTLSWLIDLLLHHPRALARVRAEAVSGDTGYTEAVIAETLRLRPAAPITGRMTTGPYRLGDYTL EPDTRIVLLLDVINRNPDTYPQPDEFRPERFLGSRPHPYAWIPFGGGVKRCIGAAFAMRELTTTLHTVLR EGELEPVSARPETPPLRAAPVLVPRDGTRVRFTPARPAASPRCADRTSTV

CYP138A1    Mycobacterium tuberculosis
            GenEMBL Z92770
            Rv0136

CYP138A1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome 163556..164881
            Gene = cyp138 100% match
            locus_tag = Mb0141

CYP138A2    Mycobacterium smegmatis
            66% to CYP138A1
MTATVERPESAIRAAQLPPVLPLPKTVQGLAFSVARRWVVKQAARRYGDV
VTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPNLSRMLGPGSVFAL
DGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAASWPDGQEFRTLEP
MMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRNYGR
LTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGS
SMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAATD
DNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAH
IQEREEEFSDPHRFDPQRFVGNRPGLGWLPYGGGTRRCVGAVFANIEMDV
VLRTILRHFVIETTTAPDEKVHPRGVAYTPASGGRVVMRRRREPLGA

CYP138A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0346
           75% to 138A1

CYP138A3P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 138A3 M. marinum = ortholog except for insertion 

CYP138A4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3976
           55% to 138A1

CYP138A4P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 138A4 M. marinum = ortholog in the conserved region

CYP138A5   Mycobacterium vanbaalenii PYR-1 
           ZP_01206398.1, EAS24160.1 
           70% to 138A1
MSEATIAAHRSTADAESAPPRPVRLPPTPRIPKLLQGLGFSFSRQWTVAQIVRRYGDVFSMTLPVFGPTV MVADPALAKQLFMANTDDVGNIQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEET LREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTPHRTYGRFS PWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRSTYEDGSTMSRQDIGDELLTLLAAGHETT AATLGWAFERISRHPEVLAKLVAEAETDGNEYRQATILEIQRSRTVIDFAGRHVYAPTFELGEWVIPQGY SIVVAIGQVHKRAQDFDDPDRFDPQRYIGQRPPTFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVI 
ETTAAPGEKMHSRGVAYTPKDGGRVVMRRR

CYP138A6P   Mycobacterium leprae
            GenPept CAC32181 GenEMBL AL583926
            NC_002677 complement(3167438..3168451)
            locus_tag = ML2648
            Sequence below is from TIGR primary nucleotide sequence for ML2648
            40% to CYP138
  1 NRVAREIVVEVIYGALFGAFEALSGLVPQDTVLGPMGRYSMAPSLIR
439 ITINVIMRAGFGSELDELRRLHPTAATL 522
    RWTVERQARCNHDIFMLDSRSTAERLRRRLHGTCMKNH 351
352 VRIFEAEPLWGLRTGLKASLLPHCRLINRITINVIMRAGFGSELDELRRLHPTAA 516
517 TLVGLF*LLSQHLGVLADPSSMGATMPGDDPAPALRQATIPG
638 LGVQWTRTVIDFAARRVYSSVYHLSEWAIPREDSILISIAQIYXXXXXXXXXXXX 766
795 DPRRYVEHKPSSFAWI 842
    PFSGGT 861
862 SRCVSICQDGDGMNVVLKMVLRYWIIDTTTAPGER*HLRGVVYTPRNGGR 1011

CYP138B1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4430
           65% to 138A1

CYP138C1   Mycobacterium vanbaalenii PYR-1 
           ZP_01207105.1, EAS23276.1 
           49% to 138A1, 48% to 138B1 
MATATTDPVRLPPGPRIPKLIQGAAVLTQRYGAIAALGRRYGPTFTLNIPVFGETVVISDPVLVKDLFST HRDLVGRPQNNLGGDVLGPGSIFNLEGDALQARRKLLLPPFNGKSMRGYASITEEEAIREIRTWPEGVEF ETLEPMMRITLNTILRAVFGAEGEQLDELRELMPKAVEFGSKIALMPSIVRKDFGPWSPGGKFARYRKRM DELLNGLLNDARSDPNFTERNDVLSLLLQARYDDGSPMPDSFILDELLTMLVAGHETTSTQLAWTIERIR RHPQLLVRLTEEVDAGGNELLLATIAESQRTRPVLTAALRRARTRIRLGEWVIPEGDTILASTQLAMAAE SSFPDADKFNPDRFVGNPPNPFAWIPFGGGMMRCIGASFATMEMEVTLRALLREFTIEPTTEPDEKPHSR 
GVTVTPGRNGRLVVHRREHKAARATDSVSVAESS

CYP138C2   Mycobacterium flavescens PYR-GCK
           ZP_01193212.1, EAS10582.1 
           83% to 138C1
MATATTDPVR LPPGPRFPKL IQGGAVLAFR YGSVAALGRR YGSTFTLQLP VFGETVVISD
PVLVKDLFST SRELVGRPQN NLGGDVLGPG SIFNLEGDEL LARRKLLLPP FNGKNMRAYE
DITEQEVIRE MQSWPEGVEF ETLEPMMRIT LNTILRAVFG AKGDELDELR VVIPAAVEFG
SKIALLPSVV RKDLGAWSPG GKFARYRRRM DEICTQLIAD ARSDPDFTDR GDVLSLLLQA
RYDNGDPIPD AFVVDELLTM LVAGHETTST QLAWTIERIR RHPDLLARLS DEVDAGGNEL
MAATIAESQR TRPVLTAALR RARTRIRLGE WVIPEGDTIM ASTQLAMAAE QSFPDAEKFN
PDRFVGNPPN PFAWIPFGGG MMRCIGASFA TMEMDVTLRT MLREFRLEPT DEPDEKPHSR
GVTVTPGRGG RAVVRRRRTP ASGDANSVSV AETSR

CYP139A1    Mycobacterium tuberculosis
            GenEMBL Z95617 GenPept AAK45973 (with 7 more aa at N-term)
            Rv1666c

CYP139A1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome complement(1877656..1878948)
            Gene = cyp139 start codon differs by 6 aa
            locus_tag = Mb1694c

CYP139A2P   Mycobacterium leprae 
            GenPept CAC31622 GenEMBL AL583921.1
            NC_002677 complement(1474970..1475188) and
            complement(1474991..1475161)
            locus_tags = ML1237 ML1238
            61% to CYP139A1
GAAVATTSMTVILARLASRTRLHLLAHYTHRVRARNFAALIP*LSLTVEVINSMPTQ

CYP139A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2475
           79% to 139A1

CYP139A3P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 139A3 M. marinum = ortholog in the conserved region

CYP140A1    Mycobacterium tuberculosis
            GenEMBL Z97193
            Rv1880c

CYP140A1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome complement(2120751..2122067)
            Gene = cyp140A1 100% match
            locus_tag = Mb1912c

CYP140A2    Mycobacterium smegmatis
            MSMEG0673 TIGR 
            65% to CYP140A1
            76% to 140A6 Mycobacterium vanbaalenii
            64% to 140A1
MRERLRWMALHGFVRSMATLGLRRGDPQARLIADPVVRADPTTFADQMRKQGPVIRG
RVVLLTFDHAVAFDLLRSDDFQVSQLGANLPKPLRWIADKTNPGLLHPIE
PPSLLSIEPPDHTRMRKLVSSVFTTRAVATLRERVEQTAHELLDGLEAES
GVVDIVERYCAQLPVAVIGDILGVPEPDRPNILRYGELGAPSLDIGLSWS
QYQQVNEGIIGFETWLNRHLRTLRRDPGDDLLSQIITASESGATGEPLTD
RELKALAGLVLAAGFETTVNLLGNGIRMLLDHREHLETLAARPDVWPNAV
EEILRLDSPVQMTARAAVRDVDVAGTAVGRGELVVLHIAGANRDPKVFDD
PHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRAFFDRFPDARL
AGDPVRRDTRVLRGWSTLPIALGKARAAVGS

CYP140A3P  Mycobacterium leprae TN
           GenEMBL L01095.1
           48% to 140A1
VRQRLHWFAQYGFIRGIAATHH
RRSDPLARLDIALAIKANPVP
YCHKPRPRRPLVQSRISYLTANRAITHELLQSEDFHVFWLNVTLPAPSHWL
RRRTGYRTSSQYNL
LHPLLAIQ*AYHIHYRKTVSPLFAPKAVATLRDRIEQTTLALLDQLAHQHDVVDVVNRY
CSQLPVAVISDILGYP
VPDRDRSHILKFGELVAPSLDVELT*Q*YQQA*REVAGFNFWL
LKHLPQLQRTPGDNLVRHLSH*EDNKPTEISLSKSKLQAISG
GLVLATGGETTVNLLGRGI
LLLDTPEHMVMLQACPEPGHKRG*EILRLDSPIQMAARVARKDVDLAGSTIKRSQVVVLY
FGRSQPGPVRLCRSR*VQHRTPQCGKESRIFR*QEFCLENALTRAYNAVGLRAFFDHLP*
TRAAGTRSRLDTRVLRGWSTLPIALGPTRSMVS

CYP140A4   Mycobacterium avium subsp. paratuberculosis 
           GenEMBL AJ250018 complement(2795..>3145)
           59% to 140A1 runs off end
GAAARQSRPVGPRRSRRSCDRQPGPDDRAHAPPATSTSAPAMVG
LVPRRARNRDPKVFSDPTTFDVTRPNAREHLAFASGIHACLGAALARIEGATCARSFE
NFPDRSSRARNGGR

CYP140A5   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2768
           80% to 140A1, 62% to CYP140A7

CYP140A5   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 140A5 M. marinum = ortholog

CYP140A6   Mycobacterium vanbaalenii PYR-1 
           ZP_01208430.1, EAS21996.1 
           66% to 140A1
MAADLQQRIRWLALHGVIRGLSKVAVRRGQDPQARLIADPAVRADPAAFADELRGRGPVIRCRAVLMTVD HQVVNEILRSDDFRVSSLGAGLPKPLQWINRKTHPGLLHPIEPPSLLSIEPPDHTRCRKLVSSVFTTRAV AALRERVQQTANDLLDDLERESGVVDIVERYCSQLPVAVISDILGVPERDRRHILHFGELGAPSLDIGLS WRQYTQVHEGLVGFNEWLGGHMDELRRNPGDDLMSQLIQASQAADEGSRLTDRELQATAGLVLAAGFETT VNLLGNGIRMLLETPGHLETLAARPELWPNAVEEILRLDSPVQMSARFARRDVTVGGTEIKRGELVILHL AGANRDPEVFTDPHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRTFFERYPDARLAGQGSRRD TRVLRGWSTLPITLGTARAALGS

CYP140A7    Mycobacterium ulcerans
            No accession number
            Pam Small
            Submitted to nomenclature committee 10/17/2003
            62% to CYP140A1
            formerly 140A2 but that name was already assigned
            to a M. smegmatis seq. (my error)

CYP140B1    Mycobacterium vanbaalenii PYR-1 
            ZP_01206566.1, EAS24328.1 
            43% to 140A1, 47% to 140A6
MGQHAGRQAGPGGAGRPVGRSGARRSGGGQPWAARAAGRRRAQVGAGAGPGSGRAAHGRHLRRPSPRQPD RRMRSRPAVWLRWATVHGVPRAFLTVRARRGEPLARLILGRGDRLALIEEIRAAGPLMRTPVVWATADYD VCRTVLRDNDFGVADPSETGLPDALLGLIRRVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFTPRSIA ALDTRIGELTAELLDDLGRRREVDLIADYAAQLPAAVISRMLGVPDEDRARILGWGETGAALLDIGIGWR PFRAAIDGLVDVDTHLGAHFRRLHQNGADGTPFSSLALDGSLSGRELISNAALLVGAGVETTVNLIGNGI AALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTARTAHRDTEIAGVGIRKGAVIVMLLGGANRDPK VFDRPQTFDITRANARDHLAFASGIHVCLGAALARIEGATALRELFTRYPDLHLTAPAEPRDLVTLHGYR HLPVRLGRAATATRRAS

CYP140C1    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE1265 48% to CYP140A6

CYP140C2P   Frankia sp. EAN1pec
            YP_001510627.1
            ABW15721.1
            51% to CYP140A5 Mycobacterium marinum
            formerly CYP140C1P
MSVRPAVSARPALSVRPAMSVRESLRDNALGMVLDMSALPAPLRLMARLSPDPAVNGPLDPPSLLAIDPP
DHTRLRRLVSKVFTPRAVDGLRGEVERAADALLDAMADEGTVDLVGRCASRLPVTVIATILGVPAAMHAQ
FLAWGTAAAATLDFGLPYGAFRRVERAQQAINTWLRGHFEGLRRDPGEDILSQLVRLVDDGDRLTETELI
ATAQLLLAAGFETTVNLLGNGAALLMEHPDQLEYLRSGPDRW

CYP141A1    Mycobacterium tuberculosis
            GenEMBL Z95150
            Rv3121
            cosmid cY164 from Sanger Centre
            coding region 29289-30488

CYP141A1P   Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome 3441289-3441483
            aa 337-400 (first part of gene is in a deletion)
IAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT*

CYP142A1    Mycobacterium tuberculosis
            GenEMBL
            Rv3518c

CYP142A1aP  Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome complement(3898119..3898736)
            gene = CYP142A1a aa 1-197 100%
            locus_tag = Mb3548c
            In Mycobacterium bovis, a frameshift due to a single base
            deletion (c-*) splits cyp142 into 2 parts (pseudogene)

CYP142A1bP  Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome complement(3897541..3898122)
            gene = CYP142A1b aa 207-end 100%
            locus_tag = Mb3547c
            In Mycobacterium bovis, a frameshift due to a single base
            deletion (c-*) splits cyp142 into 2 parts (pseudogene)

CYP142A2    Mycobacterium smegmatis
            MSMEG5877 TIGR
            86% to CYP142A4 Mycobacterium vanbaalenii
            78% to CYP142A1
MTQMLTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQ
AVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRK
RVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPT
ERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEP
TDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLL
RHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRA
GEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLAR
LELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA

CYP142A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM5003
           92% to 142A1

CYP142A3   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 142A3 M. marinum = ortholog

CYP142A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01207590.1, EAS23149.1 
           78% to 142A1
MTSTLPALDVDLADGNFYADGRAAREAYKWMRANQPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIR PDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDKVPSIENLCDTLIDAVCERGECDFVRDIAAPLPMA VIGDMLGVLPDERDMLLKWSDDLVCGLSSTVDEQTIQKLMDTFAAYTAFTTEVIADRRANPRDDLFSVLV NAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHQDQWRQAVADPELLPGAIEEMLRWTSP VKNMCRTLTADTEFHGTSLKAGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA RLELRLMLTKILQRLPDLRLADESMLPLRPANFVSGLESMPVVFTPTAPVGA

CYP142A5    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05910
            Submitted to nomenclature committee 12/13/04
            64% to 142A1
            formerly 142A2 but that name was already assigned
            to a M. smegmatis seq. (my error)

CYP142B1    Mycobacterium vanbaalenii PYR-1 
            ZP_01204842.1, EAS25834.1 
            44% to 124A1, 43% to 268A1, 45% to 142A5
MTTAVPTHRDIDLSDRNFWARPHEERDAAFAVLRRENPVPWSRPADSDLLPPEQNLKGFWSLTKHEDIRY ASRHPEIFSSAEGITVEDFPVEIRMMSQSFIAMDAPRHTQLRGITLDAFKPRNMLRLQDWIQGHARDLIS EISHLGEGDFVDLVSVKLPGRIFGSFFGLPPGELHEKTINAAQRTLGWTDPEVRGDLTAVELFVGAVMDL HETVTTLLPERRANPGDDLLSWMVQAEFDGEKMTDDELKAFFTLLAVAANDTTRHASAHAILAFSQFPDQ RDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQDVTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKF DIARNPNPHIAFGGGGPHFCLGAALARTMLRSLLTEVYTRIPDISAPEPRYQVANFINGINSLPATWTPERR

CYP142B2    Mycobacterium sp. JLS
            ZP_01275530.1 
            89% to CYP142B1 Mycobacterium vanbaalenii
            46% to 142A5
MTTVFPETTH GDIDLSAREF WAKPPVERDA AFAVLRRENP VAWSRPADSD LLPPEQNLKG
FWSLTKHEDI RYASRHPEIF SSAQGITMED FPHEILMMSQ SFIAMDAPRH TQLRGITLDA
FKPRNMRRLQ GWVQEHARDL ISEMSHLGEG DFVELVSVKL PGRIFGSFFG LPPGEIHEKT
IDAAQRTLGW TDPDVRGDRT ALELFAGAVM DLHETVTTLL PERRANPGDD LLSWMVQAEF
DGVKMTDDEL KAFFTLLAVA ANDTTRHASA QAIYAFSQFP DQRDLLVADV EGRVDSAVEE
ALRWASPLIH MRRTATQDVT VRGAEIKAGD KVVLWYSSAN RDEDVFDDPF TFDIERNPNP
HLAFGGGGPH FCLGAALART MLRSLLTEVY TRIPDIHAPE PKFQVANFIN GINSLPATWT
PERR

CYP143A1    Mycobacterium tuberculosis
            GenEMBL AL022021
            Rv1785c

CYP143A1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome complement(2013905..2015086)
            Gene = cyp143A1 100% match
            locus_tag = Mb1813c

CYP143A2P   Mycobacterium leprae
            GenPept CAC30494                
            NC_002677 1861010..1862160
            locus_tag = ML1542
            P450 pseudogene
            Sequence below is from TIGR primary nucleotide sequence for ML1542
            55% to CYP143 Mycobacterium tuberculosis Rv1785c
   1 MSTSAKANPTHFTYCSLNYSALSMITDRGVIWKTLXX 105
 113 AKPVVFMNG*YYLNVSRKCILHTTSITKGFSSREAXXX 217
 225 PGNALPVLPXXXXXXXXXXXXXXXXXXX 251 
 278 SLNNLNKALPALRTYTVTMANAITSRGEW 364 
 366 EAMTDFANX 389
 391 LFPLQLFLVL*GLXX 429
 434 AQDRDHLIALLKDVVIGMSDKPFLSQADIADQGELCEYLVDTIAERKQNPA 586
 585 PDVLSQVLIGEDPLSEIKVLDLESL 659
 659 MLILAELDTVTATVGFSLLQPACRQQLRTMLRDKPKQIRILIED 790
 792 ILQLEPPAQITPYITTEFVNVDGMTLSPGSRVRLC 896
     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
 993 GSHLARLKLTLAVDEWLINI 1052 
     XXXXXXXXXXXXXXXXXX
1116 LFALKALALHW 1148

CYP143A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2631
           60% to 143A1

CYP143A3   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 143A3 M. marinum = ortholog

CYP143A4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2666
           75% to 143A1, 53% to 143A3

CYP143A4   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 143A4 M. marinum = ortholog

CYP143A5   Mycobacterium vanbaalenii PYR-1 
           ZP_01203645.1, EAS24637.1 
           59% to 143A1
MSALPHVLYGDLPMAADRGAGWATLREFGPVAYGDGWYYLTRRDDVLAALRNPEVFSSRIAYDDMISPVP LVPLGFDPPEHTRYRRILHPFFSPQALGVLLPSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLTLF GLPLQDRERLIAWKDAIIAFSLTNDPTSVDLTPAVELYGYLTEAVARQREKPREGILSHLLHGDEQLTDN EAVGLSLVFVLAGLDTVTSTIGATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREV TVAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLDGKLHKHWGFGGGPHRCLGSHLARMELRLVVTEWL SRIPDFELAPGYVPEITWPSATCTLPTLPLILTRKTP

CYP143B1   Frankia alni ACN14a
           YP_713572.1
           CAJ62007.1
           47% to CYP143A1 Mycobacterium tuberculosis
MSAGEAQPLTFEDLPVRDDRDAAWRLIRERGGIVQLEPDVALTDHTLVEAAFRNPAVFSSRQAFDSLGSP
LPLVPIAFDPPEHARYRHILQPFFSPRSIRPLEPELRRQLAELIAPLPARGACDFVADVASVFPVQAFLT
FFGLPLDMRDQFVAWKDAILALSDPSGAISTDEADLRHAGELFTYLSELVAARRGVPGPDVLSELLCLDG
DDALTDAEVIGLCFLFVLAGLDTVTDALGFGMERLARNPDRRQEIVDDPGLVPAAVEELLRLDPPAPFVP
RITTAQTELGGRTLPAGTRVTAYIAACNRDEARYPDPYGVDFHRGDNPHASFGVGVHRCLGSHLARLEMR
LVYEEWHRLIPHYDIAPGFAPTVKFPRGTVGLEALPLVLTPGASR

CYP143B2   Frankia alni ACN14a
           YP_715649.1
           CAJ64123.1
           45% to CYP143A3 Mycobacterium marinum
MTHKRDMRHSASHAWNESWVTRRAGERVEGTAMTDDRNNEKVTLSNLPIARDRDAAWRQLREHGRTVLLD
GGLAATDVETVETVLRQPAIFSSKKAFDVLGSPLPLVPIAFDPPDQTRYRRILQPFFSPRAIRPLEDELR
RQIVEIVEPLVRRGSCEYVSEVAGIFPVQVFLTLFGLPLEMRDQFIEWKDAILGLSDPSGNTALDEAATE
AAMATALGLFSYLADLVPARRGVAGDDVLSQLLCLEGDEALTDEEAVGLCFLFVLAGLDTVVDALSFGTD
RLIRNPDRRREIVDDPALIPAAIEELLRLDPPAPFVPRVTTEQTVLDGRTLPAGTRVTTNLAAANRDPAR
HPDPYTVNFHRGESPHLSFGAGVHRCLGSHLARLEMRLVFEEWHRLIPDYDLAPGASPQVKWPRGTLGLD
ALPLVFPASAPAAGAGGQAS

CYP143C1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7215 
           51% to CYP143B2 Frankia alni ACN14a

CYP144A1    Mycobacterium tuberculosis
            GenEMBL Z97345
            Rv1777

CYP144A1    Mycobacterium bovis subsp. bovis AF2122/97, 
            NC_002945 complete genome 2001114..2002418
            Gene = cyp144 1 aa diff
            locus_tag = Mb1806

CYP144A1P   Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha02971
            Submitted to nomenclature committee 12/13/04
            57% to 144A1

CYP144A2   Mycobacterium smegmatis MC2
           MSMEG0667 TIGR 
           67% to CYP144A1
           59% to CYP144A3 Mycobacterium vanbaalenii
MTFGCMTPPEGLGLALFRPECIQDPYPLYRRMLDTAPVHPIADSGFYAVC
GWDAVNDAIARPENFSSNLTATMTYQADGTVGAFEMESLGGKSHVLATAD
EPAHTAHRKALLPQLAARRIRAFEPFILETANSLWHSHLHDGHIEWMSAV
ANRLPMMIVGRLIGVPDADVDKLVRWGYSATQVVEGLVGQDQLTQATVAV
MELAGYITDQFRHAAQDPQDNLLGDLATACATGEMDELTAQSMMIILFSA
GGESTASLIGSAAWILASRPDIQEHLRAKPELLGAFVEEVLRYEPPFRGH
YRHVVHDTTLGGVDLPAGSRLLLLWGAANRDPSHFDAPDEFRLDRSSAKS
HLSFGKGTHFCVGAALARLEALVVLRHLLHNTANITAGDTGPWLPSLLVR
RLAHLELVTT

CYP144A3   Mycobacterium vanbaalenii PYR-1 
           ZP_01207741.1, EAS22731.1 
           60% to 144A1 
MTVGHTDLGLALFHDEFLQDPHPLYARMHAEAPVHRVGDSDFYAVCGWDAITEAVARPGDFSSNLTGAMR YQADGTVSLLPLDTLGSPTQALATADDPAHAAHRKLLVPYLAAKRVRALETFAENTMHALWQQMPAGAPV EWMAVVADRLPMTVVCKLIGVPAEDVDRIAAWAYASTQILEGRVDEHTLTAAGTAALELAGYISDKLGRA SLDPGDNLLGCIATACAAGELNNLTAQVMLVTLFSAGGESTAALIGSATQIIATRPDVQRRLRADPGLIP AFLEEVLRFEPPFRGHYRHVVRDCALAGKELTAGSRLLLLWGAANRDPARFDAPNEFQIERPNSKAHIAF GKGAHFCIGAALARFEARIVIDLLLRHTSWVDAAGPGWWLPSLLVRRLDELPLTMT

CYP144A4   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 144A2 M. marinum = ortholog
           formerly 144A2 but that name waws already assigned to 
           a Mycobacterium smegmatis seq (my error)

CYP144A4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2654
           80% to 144A1
           formerly 144A2 but that name waws already assigned to 
           a Mycobacterium smegmatis seq (my error)

CYP145A1   Nocardioides sp.
           GenEMBL AB000735
           gene for 2-carboxybenzal

CYP145B1   Streptomyces scabies
           SCAB90301
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           47% to CYP145A1 AB000735 Nocardioides sp.

CYP145C1   Streptomyces scabies
           SCAB90701
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           44% to CYP217A1 Thermobifida fusca GenEMBL NZ_AAAQ01000029b
           42% to to CYP145A1 AB000735 Nocardioides sp.
           Change CYP217A1 to CYP145

CYP146A1    Amycolatopsis orientalis
            GenEMBL AJ223998
            cosmid PCZA361 (gene 2 of 2)

CYP146A2    Amycolatopsis balhimycina
            biosynthetic gene cluster for balhimycin,
            strain DSM 5908.
            Y16952.3
            90% to CYP146A1
MFEESNALRGTEIHRRDRFAPGPELRSLMGEGTMSILQPPDSPG
GRTGWLATGHDEVRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMVTS
AFTVRRMQDFRPRIEQIVQASLDAIEAAGGPVDFVPRFAWSVATTVTCDFLGIPRDDQ
ADLSRALHASRSERSGKRRVAAGNKYWTYMTEIAARARRDPGDDMFGAVVRDHGDAIT
DAELLGVAAFVMGAGGDQVARFLAAGAWLMVEHPDQFALLREKPDTVPDWLNEVERYL
TSDEKTTPRIAQEDVRIGDQLVKAGDAVTCSLLAANRRKFPAPEDEFDITRERPVHVT
FGHGIHHCLGRPLAEMVFRAAIPALAQRFPKLRLAEPDREIKLGPPPFDVEALLLEW 

CYP147A1    Myxococcus xanthus Partial missing C-term 
            GenEMBL AF111947 CDS 1939..>2877
            42% to AF087022 partial new family

CYP147B1    Streptomyces avermitilis
            No accession number
            Submitted by David Lamb and Haruo Ikeda 9/3/02
            Clone name SAV584 50% to 147A1 from Myxococcus xanthus
            (147A1 is missing C-term so could be higher % identity)

CYP147B2    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05428
            Submitted to nomenclature committee 12/13/04
            55% to 147B1, 57% to 147E1 (partial seq)

CYP147C1    Streptomyces tubercidicus strain I-1529
            No accession number
            Istvan Molnar, Syngenta Biotechnology, Inc.
            Submitted to nomenclature committee June 2, 2003
            Clone name CypEA
            50% to 147A1

CYP147D1    Magnetospirillum magnetotacticum
            GenEMBL NZ_AAAP01002628 
            complement(814..1824) gene = Magn3224
            N-terminal is about 61 aa short
            51% to 147B1 44% to 147C1
MCAPGPGRDPQCGTGRSSSGDPPDHDRLRGQVMRCFTPQRVRGM
REKTRRITDDLIAKMAGKTRIDLVDDFSYPLPVTVICELLGVPPEDEAQFHGWATQLA
TALEPNQRGDEETQAKNEVCFNEIADYIQGLIKEKRKNPQEDILSDLATDTDGMNDFD
LIATAVLLLVAGHETTVNLITNGMLTLLRFPEHLERLRAEPETAPRLIEELLRYEPPV
HYRTRLALADIPVAGITIPKDAPVILLLAAANRDPLRFSDPDRFDPDRPDNRHLGFGG
GLHYCVGAPLARIEAEVALVSLVRRLKGLSLTENPPPYRPGASLRGPCHLRLALEEVA
EG

CYP147E1   Methanosarcina barkeri Archaea; Euryarchaeota
           GenEMBL NZ_AAAR01001943 4935..6305
           52% to 147D1 probable lateral transfer
           gene = Meth3340
MYRQGSGPNDRRQTMTQQSLYEQVLDYANRANPYPLYAKLRQTP
ITRQIDGSYVVSTYREIVSLLHDPRIGSDFRMRSA
HDRPSAGLSANQELASKNQAQDEGAETSSSNQGSETEVV
PSFIGLDPPEHDRLRRQATWPFGPPHTPGRVADMEPELILLA
NRQIDTIKGRTSIDIVEDFAYPIPVTMISELLGVPPEDQPRLHALSEAIIEDIDLDPR
QSPEEQKRRQEQSSQTFKELEQYMEVLIEHHRKQPGSDLLSGLITDHGSDGPMAQADL
VSTASLLLIAGHETTVNLITNGMLTLLRHPDVLERLRREPDLVIRLVEEFLRYEPPVQ
ILPNRVALSDITIAGTTIQKGSPVILLLASGSRDPARFHDPEKFDPDRRDNMHLGFGS
GIHYCYGAPLARLETQIALTELVQRLENPRLAHDPPPYRQSATLRGPRHLIVEIDGVK
DWEFHL

CYP147E1   Methanosarcina barkeri str. Fusaro (Euryarchaeota; Methanomicrobia)
           YP_305464, AAZ70884 GenPept, NC_007355 chr 1, 
           complement(2430095..2431423), 
  1 MTQQSLYEQV LDYANRANPY PLYAKLRQTP ITRQIDGSYV VSTYREIVSL LHDPRIGSDF
 61 RMRSAHDRPS AGLSANQELA SKNQAQDEGA ETSSSNQGSE TEVVPSFIGL DPPEHDRLRR
121 QATWPFGPPH TPGRVADMEP ELILLANRQI DTIKGRTSID IVEDFAYPIP VTMISELLGV
181 PPEDQPRLHA LSEAIIEDID LDPRQSPEEQ KRRQEQSSQT FKELEQYMEV LIEHHRKQPG
241 SDLLSGLITD HGSDGPMAQA DLVSTASLLL IAGHETTVNL ITNGMLTLLR HPDVLERLRR
301 EPDLVIRLVE EFLRYEPPVQ ILPNRVALSD ITIAGTTIQK GSPVILLLAS GSRDPARFHD
361 PEKFDPDRRD NMHLGFGSGI HYCYGAPLAR LETQIALTEL VQRLENPRLA HDPPPYRQSA
421 TLRGPRHLIV EIDGVKDWEF HL

CYP147F1   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           55% to 147B1 if 9 aa removed, 54% to 147E1
           clone name SP0549

CYP147F2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7351 
           57% to CYP147F1 Streptomyces peucetius
           60% to CYP147F3 Streptomyces bingchenggensis

CYP147F3   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9076 
           68% to CYP147F1 Streptomyces peucetius 
           60% to CYP147F2 Streptomyces bingchenggensis

CYP147F4    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY4255 73% to CYP147F1

CYP147G1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2930
           41% to 147B1 41% to 147E1 45% to 147A1

CYP147G2   Mycobacterium vanbaalenii PYR-1
           ZP_01203548.1, EAS24540.1
           44% to 147E1, 69% to 147G1
MTTASQAWAQAMAFAHRADPYPFFAELRKTPVARVADDLYVVTGYYELLALAHDPRVSSDFRRSPLSSDR APAEPADDVGAYGSEPSLIVTDPPSHDRARRQVSRHFAPPHSPDLIPSMEPAVVALCNDLLDTAKANGRT RIDVVDDYAYPVPVMVICKILGVPLEDEPRFHAWIFDMLAGVDLGPDATTDEGQGRAARARDAQAALRDY LAGLIEGYRGAGGDGLLSALVNDASGPDGAMPPGQALANAVLLLIAGHDSTVNTISNCVLTFLRNPGTVE LLRDRPELIPRAIEEVQRLQSAVQFFPSRSATADIEVGGTVIPEGAAVHLMYGAANRDPRRFADPDTFDI FRPDNEHFGWGSGIHTCVGGPLARLEVNLALEIFLRRVHRPRLVSDPPPYRQSQIFRGPRHVLVDVEAIG D

CYP140H1P   Frankia sp. EAN1pec
            YP_001510211.1
            ABW15305.1
            58% to CYP147B2 Rhodococcus sp. RHA1 I-helix
MAELAAKRHDAPRDHMLSGLVSDDGPQGRMSQAEPITTAILLFVAGHETTVDLITDGMLIFLRHPELLEW
MRREPDLMAGAVEELLRYEPPVHMLPQRTTLTDVEIAGTTIPRALRSP

CYP147J1    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE7364 46% to CYP147F1

CYP148A1    Deinococcus radiodurans R1 
            GenEMBL AE002083 CDS 1719..2948
            38% to AL049754 complement(10413..11648)

CYP148A1    Deinococcus radiodurans
            GenPept AAF12079 
            GenEMBL NC_001263 2539498..2540727
            Gene = DR2538
  1 MTASSGSSAP SSGPLLAAVQ GLWSGAALAD PHPIYEQIRG FANADGLVRL PEWNTAFAVG
 61 HAATSAVLRS PAARSGEWDH GPSDGGKLLQ HMMLFRNGIP HARLRGLVQK AFTPRVVEEQ
121 RDLVRSLLDE LLSDMARAGG PVDLVAGLSG PLPGRVIMRM LGLRGADEER FLGWSASVAE
181 LLGGADRSPA LLARIEADAR EMRGYFRDLA DELRVSPQPG LLSALAAVED GGERLSGDEL
241 LSNAVLLLAA GHETTSNLIP GGVLALSQQP GAWAALLNHP RHPGVADELL RHVSPVQLDG
301 RMLTEAQTVG ETPLPAGTPV QLLLAAANRD PQVFPDPERL DWDRPNASRH LAFAAGPHYC
361 LGASLARLEI AETFAALAER FPDLRVSAAP HYKANFVLRG PQELWVTLG

CYP149A1    Microcystis aeruginosa 
            GenEMBL AB036790 CDS complement(779..2254)
            gene="mapks"
            41% to 107H1 partial seq new family
            46% to CYP1011A1 C-term
            note="In CYP149A1 the amino acid residues 2 to 200 are similar to
                  polyketide synthase
                  The amino acid residues 217 to 502 are similar to
                  cytochrome P450.

CYP150A1     Mycobacterium species
             GenEMBL AF107046
             Pascal Poupin
             gene 1

CYP150A2     Mycobacterium smegmatis mc2155
             GenEMBL AF107047 1092..2405
             MSMEG4769 TIGR 
             Pascal Poupin
             gene 2 
             61% to 150A4, 57% to 150A3, 82% to 150A1
             84% to CYP150A7 Mycobacterium vanbaalenii
             60% to CYP150A8 Mycobacterium vanbaalenii
             58% to CYP150A9 Mycobacterium vanbaalenii
             56% to CYP150A10 Mycobacterium vanbaalenii
MTDSTATDPAATTPDFDTVDYFTDQSLVPDPHPYFDHLRSKCPV
VREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPFPPLPFTPEGDDITGQIEQHRT
QLPMFEHMVTMDPPEHTNARSLLNRLLTPKRLKENEDFMWRLADECLDDFIDDGSCEF
LKQYAKPFSLLVIADLLGVPEEDHDEFRHVLGAPRPGAIVGSLDGDQLAMNPLAWLDD
KFVRYLEDRRKEPRDDVLTALATAKYPDGSTPEVIDVVRSATFLFAAGQETTTKLLSA
SLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAKKTTQLGGVDVPAGT
TLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSLER
ILDRMADIRIDEEHHGPADNRRYTYEPTYILRGLTDLHIKFEPVR

CYP150A3   Mycobacterium smegmatis
           MSMEG4812 TIGR has extra seq (lower case) 
           but this may not be real protein seq
           56% to CYP150A1 47% to CYP150A4
           56% to 150A2
           74% to CYP150A9 Mycobacterium vanbaalenii
           62% to CYP150A10 Mycobacterium vanbaalenii
           55% to CYP150A7 Mycobacterium vanbaalenii
mtakrrcgnvilnnerhvlirlspsgngvth
MAIDPAGIDWFKDPRLVDDPYPYFNALRDKCPVQSEDHYGVTMVTGWEEA 
VSVYNDEKSFSSCTSVTGPFPGFPVPLEGRDDVAELIEKHRDELPFSDQL 
PTLDPPVHTNHRSLMMRLITPKRLKENEDAMWQLADEVLDDFLAPGKGEF 
IKGFASPFTLLVIADLLGIPAEDRNAFVDGISQNSGGGVGSTGDESLSHS 
PLEFLYGQFEAYIEDRRSNPREDILTGMATALFPDGTTPSPGDVARVATN 
VFSAGQETTVRLLGTALKVLGDRPDVQKMVREDRSLLPNFIEEALRHESP 
VKGDFRLSRCPVTVGDKDLPSGRTVMVVNGAANRDPRRFENPDDFDPARK 
NARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTTDIRISEEHHGPAA 
NRDYKYIPTFILRGLTHLHLEFDVK

CYP150A4   Mycobacterium smegmatis
           MSMEG5988 TIGR
           61% to CYP150A2
           47% to CYP150A3
           81% to CYP150A8 Mycobacterium vanbaalenii
           61% to CYP150A7 Mycobacterium vanbaalenii
           49% to CYP150A10 Mycobacterium vanbaalenii
           51% to CYP150A9 Mycobacterium vanbaalenii
MTDLASVDYFSDPAVAQDPYEYYDFLRSRGPVTTEPHYGVVAVTGYQEVM
AAFKDHDSFSAVNAIGGPFPPLPFTPEGDDITEQIEAHRHLFPIHEHMVV
MDPPAHERARSLLSKLLTPRRLKENEDFMWQLVDRQLDAIIGNQADEGRC
EFLSEYAKPFATSAIIDLLGVPEEDRAEFLEALGAAPREGARVGALDGEP
VGLDPLQYLDCKFAGYLAERRREPRGDVLSGMATATYPDGSTPDLMEVVK
PATFLFAAGQETVTKLLSSAVQTLAERPEFQERLRKEPDLIPVFIEEALR
TQSPTKVDFRLARKTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFR
IDRPNVREHIAFGRGIHTCAGAPLARVEGQITVRRMLDRLRDIRIDATRH
GPADSRTYAYEPTFLLRGLTKLHIEYTPA

CYP150A5   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4737
           57% to 150A2
           formerly CYP150A3 but this name was already assigned to 
           an M. smegmatis seq (my error)

CYP150A6   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4694
           97% to 150A6 M. ulcerans

CYP150A6   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           70% to 150A2 M. smegmatis, 55% to 150A3 M. marinum
           formerly CYP150A4 but this name was already assigned to 
           an M. smegmatis seq (my error)

CYP150A7   Mycobacterium vanbaalenii PYR-1 
           ZP_01205741.1, AAS77249.1, EAS26733.1 
           91% TO CYP150A1 Mycobacterium species
MSDFDTIDYFTDPSLVPDPHPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPFP PLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDI ISRDPVGRCEFLSAYAKPFSLLVIADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANPLEWLDE KFIGYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASLRVLGDHPDIQ ERLRRDRSRIPIFVEEALRMDAPVKSQFRLAKKNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDL DRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPTFILRGLTD LNITFTPVR

CYP150A8   Mycobacterium vanbaalenii PYR-1 
           ZP_01207544.1, EAS23103.1 
           60% to 150A2 
MTDLASADFFSDYALSQDPHPYWDHLREQNPVYREPHYGVVAVTGYQEVLAAFKDHDSFSAVNAIGGPFP PLPFTPEGDDITEQIEAHRHLFPIHEHLVVMDPPAHERARSLLNKLLTPRRLKENEDYMWQLVDSQIDQV IGKGRCEFLSEYAKPFATSAIIDLLGVPEEDRPEFLAALGAEQPDGARVGALDGEPVGLDPLQYLDDKFA GYLAERRREPRGDVLSGMATAVYPDGSTPELIEVVKPATFLFAAGQETVTKLLSAAVKTLAEQPEYQRIL RAHPDRIPTFIEESLRMNAPTKVDFRLVRKTTTLGGVHLKAGTIVMLCLGAANRDPRKFEDPHEFRPERK NVREHIAFGRGIHTCAGAPLARVEGQITVRRWLDRTDEIHLDESVHGPAGQHHFAYDPTFLLRGLSQLNI EFTAAT

CYP150A9   Mycobacterium vanbaalenii PYR-1 
           ZP_01205777.1, EAS26769.1
           58% to 150A2
MAEDLTTVDFFRDSRLTDDPYTFYEALRNKCPVSREEHYGVTMVTGWQEAVDVYNDAESFSSCVSVTGPF PGFPVSLEGRQDDDITALIEQHRDEIPFSDQLPTLDPPTHTNHRALLMRLITPKRLKENEDAMWQLADDI LDDYLAQGEGEFIKGFAGPFTLRVIADLLGVPEEDRPELLERLAKGTHGGGLGNADKTLTKTPLEYLYDV FATYVEERRAEPRDDVLTGLATANFPDGTVPEVGDVVRVATNVFSAGQETTVRLLSTALKVIGDRPDIQE RLRADRSLLPNFIEECLRIESPVKGDFRLSRVPTTIGDQALGAGCTVMVINGAANRDPRRFEDPDAFDPE RKNARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTSDIRISESKHGPAGNRRYDYIPTYILRGLTEL HLEYDVR

CYP150A10   Mycobacterium vanbaalenii PYR-1 
            ZP_01205906.1, EAS26898.1 
            55% to 150A2
MTEQLTPTDIDEVDFFTDNTVLHDPYGYLAAMRNECPVRRERHHDVVMITGYEEAVAVYNDNARFSSCTA VTGPFPGFPVPLVGDDVSGLIAEHRDKLPFNDQLPTLDPPLHTDHRALLSRMITPKRLKENEEFMWRLAD RQYDEALAGGRCEFVGEFGNPFAMLVIADLLGVPESDHNDFKDQLLTSTGTIGSSGGDAMHHSPLEYLYG KFTDYITDRRENPRDDVLTGLASALFPDGRTPPVIDVVCVAANLFAAGQETTVRLLSTAVMMIAEDPALQ AKLRADRSLIPGFVEEALRFESPIRGDFRLSKVPVSVGGVELPAGTTVMLNNAAANRDPRRFTDPDTFDL QRPNARQHIAFGRGAHSCPGAPLARAEAKVSINRLLDRTSDIWIDEDKHGPVDARRYKYLPTFILRGLTR LHIEFS

CYP150A11   Frankia sp. EAN1pec
            YP_001508962.1
            ABW14056.1
            71% to CYP150A3 Mycobacterium smegmatis
MREFEAMDFFRDETLVADPYPYLDALRRKCPVQRERHHDVVMVTGYEEAVEVFHDSEAFSSCVSVTGPFP
GFPVPLDGDDVSALIERHRHELPMNDQLPTMDPPTHTDHRALLMRLITPKRLKENEALMWDLADRMLDPF
LTPGEGEFISGFAGPFTLLVIADLLGVPEEDQDEFLDKLQRQPAQTGGVGGTGAETLAHSPLEFLYGKFT
GYIEDRRRNPRADVLTGLAGATFPDGSTPEVIDVVRVAANLFSAGQETTVRLLSSALKILAERPDLQRQL
RVERERIPAFIEETLRWESPVKGDFRLSRVPVTVGGVQLPAGTTVMVVNGAANRDPRRFENPETFDVARS
NARQHLAFGRGIHSCPGAPLARAEARASLERLLDRTTDIRVNERVHGPAGNRRYEYMPTFILRGLTALHL
EFDLAPAPPRDFPPAGSPVGWIKG

CYP150A12   Frankia sp. EAN1pec
            YP_001508233.1
            ABW13327.1
            69% to CYP150A5 Mycobacterium marinum
MSELETKDFFRDEELVADPYPFLEAMRGKCPVQRENHHDVVMVTGYDEAVQVFHDSATFSSCVSVTGPFP
GFPVPLEGDDVTELIERHRGELPMNDQLPTLDPPTHTAHRALLMRLITPKRLKENEAQMWRLVDQMVEPY
LAGGEGEFITGFAGPFTLLVIADLLGVPEEDQEEFLDRLQRQPQESGGIGSTGDDHMAHNPLEFLYNKFT
AYIEDRRREPREDVLTGLALATFPDGSTPEVIDAVRVAANLFSAGQETTVRLLSSALKILAEDRELQQLL
RAEPDRVGNFIEETLRLESPVKGDFRLSRVPTTVGGVDLPAGTTVMVVNGAANRDPRRFENPSVFDVARP
NARHHVAFGRGIHTCPGAPLARAEARASIERLLERTTDIRISESVHGPADDRRYSYLPTFILRGLTHLNL
EFTLAESKTP

CYP150A13   Frankia sp. EAN1pec
            YP_001507995.1
            ABW13089.1
            69% to CYP150A5 Mycobacterium marinum
MKDIEAIDFFRGDELVADPYPYFHALREQCPVRREPHHGVVMVTGYEEAVSVFHDSDRFSSCTSVTGPFP
GFPVPLEGLEGDDISELIERHRAELPMSDQLPTFDPPMHTDHRALLMRLITPKRLKENEEFIWRLADRLL
DEYLASGEGEFIRGFAGPFALLVIADLLGVPEEDHEEFTDRLQHRPAEGGGVGSTGDHSMEHSPLQFLYD
RFTTYIEDRRREPRDDVLTGLATATFPDGSTPEVIDVVRVAANLFSAGQETTVRLVSTAAKLIADNPGLQ
RLLRAERDRIPNFIEETLRLESPVKGDFRLARVPTTVGGVDIPAGSTVMVVNGAANRDPRRFADPDTLDV
ARPNARQHIAFGRGIHSCPGAPLARAEARAGLERLLDRTADIRISERVHGPAGARNYQYLPTFILRGLTH
LQLEFTPAASDSR

CYP150A14   Frankia sp. EAN1pec
            YP_001504962.1
            ABW10056.1
            60% to CYP150A2 Mycobacterium smegmatis
MTDWTTTDFFNDESLAEDPYPYFDELRSVCPVLPLPHLGVVAVTGYDEAHEVYRDVDTFSSCNSVVGPFA
TFPVPLEGDEVGAIIDRHRDQLPMNEHMVTMDPPMHTRERALVMRMLTPKRLQENEAFIWRLADQQLDEF
IADGRCEFIRAYAQPFSMLAVADVLGVLESDHQRFREGFGLTVSPGQIGAGEQTDGELNALGWLDAWFAR
YIESRRHEPRNDVLTQMAAATYPDGTTPEVTSVVRAATFLFAAGQETTARLLGAALKFIAENPGLQEEIR
EHRERIPDLIEETLRVESPVKADFRLARRTTTIGDVEVPAGTPVMLLNGAANRDPRQFECPAEFRISRRN
VRQHIAFGRGIHSCPGGPLARVEGRISLERILDRTRDIRISEEHHGPPDARRFDYEPTWILRGLTNLHLE
FTPVESAR

CYP150A15P  Frankia sp. EAN1pec
            YP_001505067.1
            ABW10161.1
            59% to CYP150A2 Mycobacterium smegmatis
MSDWKTIDYFTDESLVADPYPYFDELREAGPVLPLPHLGMVAVTGYEEASQVYREAETFSSCSSVVGPFA
TFPVPLEGDDVSEIIDRYRTRLPMFEHMVTMDPPDHTRERALLMRLLTPRRLKENERFISRQADRQLDEF
IDRGTCEFVREYAQPFTMTGPLTSGCPKSTTGRRVPGVSPTTPPGSCAA

CYP150A16   Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            66% to CYP150A12 Frankia sp. EAN1pec

CYP151A1    Mycobacterium smegmatis
            GenEMBL AF102510
            Poupin P, Ducrocq V, Hallier-Soulier S, Truffaut N
            Cloning and Characterization of the Genes Encoding a Cytochrome
            P450 (PipA) Involved in Piperidine and Pyrrolidine Utilization and
            Its Regulatory Protein (PipR) in Mycobacterium smegmatis mc2155.
            J Bacteriol 181, 3419-3426 1999

CYP151A2    Mycobacterium sp. strain RP1
            GenEMBL AJ310142
            Pascal Poupin 
            Submitted to nomenclature committee March 22, 2001
            86% identity in 399 aa overlap with CYP151A1

CYP151A3    Mycobacterium vanbaalenii PYR-1 
            ZP_01205617.1, AAS49915.1, EAS26609.1 
            88% TO CYP151A1 Mycobacterium smegmatis
MSSATVGSVPAFAVTDPGFSITSAEVHAARERSWYATTEYGLAVLRYEQVNRLLKHPKLRQGSAAWPAHN GVTEGPFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRFQALAAELIDGFAEPGRCEFVGEFA EPYAARVIAIMLGLPESEWKVIATESATIGLALGVTILDDLPRIEAALAHLYEYCDELIADRRASPRDDF VTTLVNASRPEDGRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGNAVEEV MRVNPTVRWVTREVLEDFEYEGVELAAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGVHHCLG HFVARSDMSEALPLLARRMLDPHELPGATWLPDSGNTGPITLPIGFTPAS

CYP152A1    Bacillus subtilis
            GenEMBL AB006424
            ybdT gene
            this sequence is missing part of the heme signature sequence, but has 
            PERF and EXXR

CYP152A2    Clostridium acetobutylicum
            GenPept AAK81262                 
            YBDT B.subtilis ortholog
            59% to 152A1
  1 MLLKENTAKD KGIDSTLDLL KEGYLFIKNR ADHYQSDLFE TRLMGQRIIC MTGEEAARIF
 61 YDSDKFKRQG AAPKRVQETL LGENAIQTLD GESHLHRKKL FMLLTNQVQQ KRLAELTTEK
121 WEASASKWHT KSIVLFNEAN EILCQVACHW AGVPLMESDI KNRAEDFSSM IDSFGAVGPR
181 HWKGKKARNT IEAWIKEIIE NVRSGRIRAE EGSPLHEIAF YIDVNGQQMP AEMAAIELIN
241 ILRPIVAIST FITFSALALY EHSEYREKLQ SKDIRYLEMF TQEVRRYYPF APFVGARVRK
301 DFLWNNCEFK KEMLVLLDIY GTNHDSRIWQ KPYEFIPDRF RSYKGNLFDF IPQGGGDPSS
361 THRCPGEGIT LEIMKTSLDF LSTKIDFTVP DQDLSYSLSK IPTLPKSGFI IDNINLKL

Note on Clostridium acetobutylicum.
This organism is classed as an obligate anaerobe, however the article below 
Shows that it grew well in a microoxic environment and peptides were induced
Within 10 minutes of exposure to oxygen.
Kawasaki S, Ishikura J, Watamura Y, Niimura Y.
Identification of O2-induced peptides in an obligatory anaerobe, Clostridium 
acetobutylicum. FEBS Lett. 2004 Jul 30;571(1-3):21-5.
Furthermore, all three classes of ribonucleotide reductase are present
In the genome.  
Torrents E, Aloy P, Gibert I, Rodriguez-Trelles F.
Ribonucleotide reductases: divergent evolution of an ancient enzyme.
J Mol Evol. 2002 Aug;55(2):138-52.
Class I RNR absolutely requires oxygen to generate a free radical on Cys.  
Class III is poisoned by oxygen and class II can work either way.  
The P450 in an anaerobe is odd, but the CYP152A1 is a peroxygenase not
A monooxygenase, so CYP152A2 is also expected to be a peroxygenase.
The other facts mentioned above may suggest C. acetobutylicum is not 
Completely unable to be exposed to oxygen.  The P450 might serve a protective 
role, or it may be an oxygen sensor, producing a signaling molecule in response to 
oxygen/hydrogen peroxide. Alternatively, it may have recently become an anaerobe 
and still has oxygen metabolic enzymes left over from an aerobic past.

CYP152A3    Clostridium lentocellum DSM 5427
            GenEMBL YP_004308874
            58% to CYP152A1 Bacillus subtilis

CYP152A4    Bacillus amyloliquefaciens FZB42
            YP_001420702.1
            70% to CYP152A1 Bacillus subtilis

CYP152A5    Clostridium botulinum A2 str. Kyoto
            YP_002803405.1
            68% to CYP152A2 Clostridium acetobutylicum

CYP152A6    Bacillus halodurans C-125
            NP_242623.1
            57% to CYP152A1 Bacillus subtilis

CYP152A7    Clostridium phytofermentans ISDg
            YP_001560008.1
            68% to CYP152A3 Clostridium lentocellum DSM 5427

CYP152B1    Sphingomonas paucimobilis
            GenEMBL AB006957
            Isamu Matsunaga
            this sequence is missing part of the heme signature sequence, but has 
            PERF and EXXR

CYP152B2    Azotobacter vinelandii
            NZ_AAAU02000007 102969-104183
            56% to CYP152B1 with two frameshifts 
            may have 10 aa deletion after aa 136
MHRIPRDKGLDSTLALLHDPYRFIARRCRLHGSNLFETRLLLRKTLCMSGAEAARLFYDP
ERFVRHGAMPPRLQKTLFGVGGVQGLDGEAHRHRKHMFVALLMDAERVAQLVEAVRGEWR
TCARRWERMEKVVLYD 
CAWAGIPLAEEEAGPRAREIALLFDYAGSVGPKHWRSRLARRRSEAWMGALVESIRASRR
QPPAETAAQVISWHRGLDGNLLEAR
VAAVELLNVIRPVVAIAVYLTFVAHALHRYPHCRHGLRSGDAEYREWFVQEVRRFYPFFPA
VVARVRQDFEWRGYAFPAGRRVMLDLYGTDHDVRLWQAPETFRPERFGSREYGPCDFIPQ
GGGEHESGHRCPGERIVMKLGADVLARELSYAVPMQNLEIDFSRLPALPRSRFVMSDIHGAP*

CYP152B3   Chelativorans sp. BNC1
           YP_665837.1
           58% to CYP152B1 Sphingomonas paucimobilis
           58% to CYP152B2 Azotobacter vinelandii
           82% to CYP152B4 Sphingopyxis alaskensis RB2256

CYP152B4   Sphingopyxis alaskensis RB2256
           YP_617595.1
           59% to CYP152B2 Azotobacter vinelandii
           82% to CYP152B3 Chelativorans sp. BNC1

CYP152B5   Kytococcus sedentarius DSM 20547
           YP_003150307.1
           52% to CYP152B1 Sphingomonas paucimobilis
           55% to CYP152B3 Chelativorans sp. BNC1
           55% to CYP152B4 Sphingopyxis alaskensis RB2256

CYP152C1   Rhodobacter sphaeroides 
           GenEMBL NZ_AAAE01000129 complement(38633..39955) 
           gene = Rsph2136
           also YP_352437.1, ABA78536.1
           40% to 152A1, 41% to 152B1
MTTDEGRRPEEPGTPASLREMPRDPRIDASMALMSEGYRFVSNL
CDRMDSDAVATRLRLREVVCLRGSAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQ
LEGPAHRHRKALFLSICMDPARVEALVSEMRLAWRERLPAWEAEGRIVLQQEAARLLT
RAGCRWAGVAHQPEAQLADEIFDMIDKAGSVGPRNWLAQMRRAGTEKRLRTLVEEVRA
GEVVPEAATALHAIAFHREEDGTLLDPSVAAVELLNLLRPIVAVGRYITFAALALHRE
TTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPITWEGYDFPEGQWLLLDLY
GTTHDPRHFPEPTRFRAERMLSWTGQDEAFIPQGAGDVARTHRCPGEMITVELMKEAI
RLLCCEMDYEVPAQDLGVRLNRMPAQPRSGMILSAISRRAGTEASRNG

CYP152C2   Rhodobacter sphaeroides 
           ZP_00915817, EAP62861.1
           78% to 152C1
MSNSDARHEA GPSDTTCGRE IPRDPRLDAS MGLLSEGYRF VSNLCDQLDS DIVSTRIRLR
EVICLRGGTA ARLLYGAEGL TRVGAMPSSV LHLLQDKGSV QQLEGPAHRH RKALFLGICM
DPARVEALVA EFRAAWRAAL DEWEEADSIV LQQEAARVLT RAACRWAGVE NQPEARLAEE
IFDMIDKAGS IGPRNWLAQM RRSGTERRLR KLIEQVRAGE VVPGSATALH AIAFHREADG
ALLDDTVAAV ELLNVLRPIV AVGRYITFTA LALHRETNWR DLFRSGTLEL AADFAEEVRR
ISPFFPFTAA VTTRPLQWEG YDLPADQWLL LDLYGTLHDA RNFPDPARFR AERMLSWSGQ
DDCFVPQGGG EVAVTHRCPG EMITVELLKE AIRLLCLEMD YEIPPQDLGV RLNRLPAQPR
TGMVLASIRR RPGTEPCVAG

CYP152D1   Streptomyces scabies
           SCAB80661
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           42% to 152A1, 42% to 152B2, 39% to 152C1

CYP152E1   Cyanothece sp. CCY0110
           ZP_01728364 
MIKKIPQDKWIDSSLALIFDGYDFISKRCKRYQSNIFQTRLMLEKTICFKGEEAAKIFYDKTKFTRKNAA
PDRVKKTLFGEKGIQGMDGDAHLHRKQMFMSLMSKERIQEVGTLTQKQWHNYAKKWERMDTIVLFEEARE
VLCRVACTWAGVPLEESEVKLRSQQFEAMIAGSGVVGPKHWQGRKARKENEQWIETIIEKVRNHQLEVPE
ISATYIFANHRDLSGELLDKRVAAVELINVLRPIVAIDRYITFGALALHEHPECRPKLLESEDYLRAFVE
EIRRFYPFFPFASARVRQDFDWQGYHFPEGTRVLLDLYGTNRDPQSWDKHDVFYPERFLNFSELDSFKFI
PQGGGDYHTNHRCPGEWITIELLKVTMTFLIQSINYNVPKQDLRINHLKMPTVPASGFVIKNVNLC

CYP152F1    Rhodococcus sp. R04
            AFAQ01001450 1011-2294 (-) strand
            Riu Xue
            Submitted to nomenclature committee Dec. 26, 2011
            41% to CYP152D1 Streptomyces scabies

CYP152G1    Rhodopirellula baltica SH28
            GenEMBL ZP_16052477
            52% to CYP152B1 Sphingomonas paucimobilis

CYP152H1    Sporolactobacillus vineae DSM 21990
            GenEMBL ZP_10970070
            52% to CYP152A1 Bacillus subtilis

CYP152J1    Oceanobacillus iheyensis HTE831
            GenEMBL NP_694023
            41% to CYP152A3 Clostridium lentocellum DSM 5427

CYP152K1    Bacillus clausii KSM K16 
            GenPept BAD65574
            53% to CYP152H1

CYP152L1   Jeotgalicoccus sp. ATCC 8456 
           E9NSU2_9STAP
           Terminal olefin-forming fatty acid decarboxylase OleT

CYP152L2   Staphylococcus massiliensis S46
           K9B6J8_9STAP

CYP152M1   Enterococcus faecium
           NZ_AAAK01000185 complement(2963..4222) 
           Gene = Efae1119
           36% to 152B1
           formerly CYP241A1, name changed
MKEVPVVDIKITDLKKLYQKGYNMLEELRHEADAPVVKAKIFNK
EAITIYGSSAAKVFYDPRNFKRKGAMPKLVLKTLFGQGGVQTLDGAAHHHRKNIFMDL
MTPERMEDYHRILDKNLTQALEAQHGQFELFDLSKMVFFTSICEWAGINLSAISKDEV
EKLAEYQISMISGTFTSPIDHIKGVENRKKSEKWAQGLIEEARQNPVAGKENVALYAF
ANATDLDGQLLPLEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFSTL
QDPFIQEMRRYYPFFPMLPAISLKEVEVDGYRIPEGSWVILDLYGTDHDERTVEAPDS
FMIKRYVGKAKDISYKEEYEMIAQGGGNFRQMHRCAGEWITLHSLRVFSDQLVNKFEF
SVPEQDWTIPFNQFPTYPNSRALLYKN

CYP152N1    Exiguobacterium sp. AT1b
            YP_002886666.1
            48% to CYP152K1 Bacillus clausii KSM K16
            44% to CYP152H1 Sporolactobacillus vineae DSM 21990

CYP152P1    Methylobacterium populi BJ001
            YP_001923998.1
            60% to CYP152P2 Methylobacterium sp. 4-46
            45% to CYP152A1 Bacillus subtilis

CYP152P2    Methylobacterium sp. 4-46
            YP_001771085.1
            60% to CYP152P1 Methylobacterium populi BJ001
            47% to CYP152H1 Sporolactobacillus vineae DSM 21990

CYP152Q1    Arthrobacter sp. AK-1
            YP_001742037.1
            44% to CYP152G1 Rhodopirellula baltica SH28
            47% to CYP152C1 Rhodobacter sphaeroides

CYP152R1    Pseudomonas stutzeri A1501
            YP_0011173755.1
            47% to CYP152E1 Cyanothece sp. CCY0110
            46% to CYP152G1 Rhodopirellula baltica SH28

CYP152S1    Methylobacillus flagellatus KT
            YP_545551.1
            49% to CYP152H1 Sporolactobacillus vineae DSM 21990
            49% to CYP152E1 Cyanothece sp. CCY0110

CYP153A1    Acinetobacter calcoaceticus
            GenEMBL AJ311718.1  
            MAIER; T; FOERSTER, H.H.; ASPERGER, O. AND HAHN, U.: 
            Cloning of an unusual 56 kDa-P450 from the n-alkane-assimilating 
            bacterium Acinetobacter calcoaceticus EB104. 
            Unpublished
            32% identical to CYP111 58% to 153A7 57% to 153A2
            trivial name P450EB104
MNSVAEIFEKITQTVTSTAADVATTVTDKVKSNEQFQTGKQFLHGQVTRFVPLHTQVRGIQWMQKAKFRVFNVQEFPAFIEQPIPEVATLALAEIDVSNPFLYKQKKWQSYFKRLRDEAPVHYQANSPFGAFWSVTRYDDIVYVDKNHEIFSAEPVIAIGNTPPGLDAEMFIAMDPPKHDVQRQAVQDVVAPKNLKELEGLIRLRVQGVLDQLPTDQPFDWVQNVSIELTARMLATLFDFPYEKRHKLVEWSDLMAGTAEATGGTVTNLDEIFDAAVDAAKHFAELWHRKAAQKSAGAEMGYDLISLMQSNEATKDLIYRPMEFMGNLVLLIVGGNDTTRNSMTGGVYALNLFPNEFVKLKNNPSLIPNMVSEIIRWQTPLAYMRRIAKQDVELNGQTIKKGDKVVMWYVSGNRDERVIERPDELIIDRKGARNHLSFGFGVHRCMGNRLAEMQLRILWEELLQRFENIEVLGEPEIVQSNFVRGYAKMMVKLTAKA

CYP153A2   Caulobacter crescentus CB15
           GenPept AAK22050                 
           NC_002696 complete genome 61849..63153
           56% to 153A1
  1 MMSQNTDPRE DLMSDGSIDL KADARARAYS IPLEDYHVAD PALFQADAMW PYFERLRKEA
 61 PVHYSKGDEE VGPYWSVTRY NDIMTVDTTH QVFSSDAHLG GITIRNFDED FVLPMFIAMD
121 QPKHDIQRKT VSPIVSPANL GRLEGIIRER VCGILDALPI NEPFDWVDKV SIELTTQMLA
181 TLFDFPWEER RKLTRWSDIA TASPESGLIE SEEARRAELL ECLAYFTNLW NERVNLTEPG
241 NDLISMLAHG EATRDMPPME YLGNVILLIV GGNDTTRNSL TGGLYALSKN PQEEAKLRAD
301 PGLIPNMVSE IIRWQTPLAH MRRTALEDYE LAGQTIKKGD KVVMWYVSGN RDDTVIENAD
361 QFIVDRPNAR RHLSFGFGIH RCVGNRLAEM QLKIVWEEIL KRFPKIEVLE EPKRVYSTFV
421 KGYERMMVRI PERI

CYP153A3   Bradyrhizobium japonicum USDA 110
           GenPept BAC52507                 
           NC_004463 complete genome 7964879..7965991
           51% to 153A1 70% to 153A4
           FORMERLY CYP153B2 CYP153A and CYP153B have merged
  1 MHYCKDSMFG PYWSVTRYND IMEIETNHSV FSSASALGGI TIRDIDPDLR RESFISMDPP
 61 RHAAQRKTVA PMFTPTHLDN LALNIRARSA ECLDNLPRGE VFDWVDRVSI ELTTQMLAVL
121 FDFPWEDRRK LTRWSDIATT IPGPDGLVAT EDERQAELTE CAGYFARLWK ERIEQPPKSD
181 LLSMMAHGAA TRDMDAKNFL GNLVLLIVGG NDTTRNTMSG SIYALSQHPE QYRKLRENPA
241 LLDSFVPEVI RWQTPLAHMR RTALSDFEFR GKQIKKGDKV VMWYVSGNRD EEAIEKPYDF
301 IIDRARPRTH LSFGFGIHRC VGLRLAELQL KIIWEEILKR FDHIDVVGEP KRVYSSFVKG
361 LETLPVKIAA

CYP153A4   Bradyrhizobium japonicum USDA 110
           GenPept BAC52508                 
           NC_004463 complete genome 7966159..7967508
           51% to 153A1
           FORMERLY CYP153B3 CYP153A and CYP153B have merged
  1 MDGRRRRPMP LPQAGEVRKT TGATTMNIQT PVKVDKAERM RRARGEAYAT PLAQFHPGAP
 61 RLFQDDTLWP WFERLRKEEP VHYCTNAPIE PYWSVVKYND IMHVDTNHGI FSSDSTLGGI
121 SIRDVPEGYD YPSFIAMDQP RHSAQRKTVS PMFTPTHLDE LAKLIRQRSQ TVLDNLPRNE
181 TFNFVERVSI ELTTQMLATL FDFPWEERRK LTRWSDVSTA LPKSGIVASA EERRREMDEC
241 YAYMSKLWNE RVNSAPRNDL LSLMAHNDAT RFMDPDNLMG NIILLIVGGN DTTRNTMTGS
301 VLALNENPEQ YDKLRANPAL IDSMVPEVIR WQTPLAHMRR TALQDTEIGG KQIKKGDRVV
361 MWYVSGNRDE EAIDRPNEFI IDRPRPRTHL SFGFGIHRCV GMRLAELQLK IVWEEMLKRF
421 DRIEVVGEPK RIYSSFIKGY ESLPVRIPG

CYP153A5   Rhodopseudomonas palustris
           NZ_AAAF01000001 
           complement(3283981..3285270) gene = Rpal2887
           80% TO 153A4
           FORMERLY CYP153B4 CYP153A and CYP153B have merged
MTWPGRTTMHGTIETGKAARLRAAREEAYATPLKDFHPGAPRHF
RDDTLWPWFERLRAEEPVHYCTNAPIEPYWSVTKYNDIMHVDTNHQIFSSDSTLGGIS
IRDAPVGYDWPSFIAMDEPRHSAQRKTVSPMFTPQHLDELAVLIRGRTQKVLDGLPRG
ETFNFVDRVSIELTTQMLATLFDFPFDERRKLTRWSDVATALPKSGVVDSEQQRRDEL
NECAAYFARMWNDRVNSEPRNDLLSMMAHHDATRTMDRDNLIGNILLLIVGGNDTTRN
TMSGSVLALNENPHEFEKLRANPKLIDTLVPEVIRWQTPLAHMRRTALQDAELGGKTI
RKGDRVVMWYVSGNRDDEVIERPEEFIIDRARARIHLSFGFGIHRCVGMRLAELQLRI
VWEEMLKRFERIEVVGEPKRVYSSFVKGYESLPVRVS

CYP153A6   Mycobacterium sp. HXN1500 
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 11/27/2003
           66% to CYP153A2 62% to 153A4 55% to 153A1 

CYP153A7   Sphingomonas sp. HXN200 
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 11/27/2003
           66% to CYP153A2
           clone name P450-A

CYP153A8   Sphingomonas sp. HXN200 
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 11/27/2003
           62% to CYP153A2 59% to CYP153A4
           clone name P450-E

CYP153A9   Bradyrhizobium japonicum USDA 110
           GenPept BAC47118
           NC_004463 complete genome 2007526..2008767
           49% to 153A1 60% to 153A6 58% to 153A2
           FORMERLY CYP153B1 CYP153A and CYP153B have merged
  1 MNRRLEIHRA DDGYIIPLSE LDVSEGKRFQ DDSIWGCFER LRREDPVHYC QNSAHGPYWS
 61 ITKYRDIVAV DTNHHAFSSQ QGVTIVEVPD KHWTPSFIKM GPPQHAEQRN TVSPIVGPES
121 LTRLETLIRS RVRMILDGLP RNEVFNWVTK VSIELTTQTL ATLFDFPFED RRLLTYWSDA
181 AVTTPKAGYA IDSWDKRSTI LSECLDYFTR LWNERINAEP RLDLISLMAH SPVTRHMEPT
241 EFLGNLILLI VGGNDTTRNS ITGGLLFMSQ YPSELRKLTD NPKLISSAVS EIIRYQTPIA
301 HMRRTAAIDS IVGGKPIRTG DKVVMWYISG NRDEEVIENA NSFVIDRKNV RQHLSFGFGI
361 HRCLGRHLAE LQLRVLWEEI LDGGLKIKVV GEPERIASNF VHGYSALPVR IEA

CYP153A10  Burkholderia fungorum
           NZ_AAAJ02000161
           complement(10797..12332) gene = Bcep0832
           56% to 153A3 58% to 153A6 57% to 153A2
           FORMERLY CYP153B5 CYP153A and CYP153B have merged
MRHVSCLRRSRLERSRGRARRPGGFHADLFTDPQGQLAALLPDR
GARGTRRTGPAPSRRPALTTLARHSNPVPDKALAPLTRNCHSAKVNCMNTLVVDSSHV
RLAPDALSQPVEDIDPSLPYRFQQQTHFAMFDRLRRESPVHYVKDSEYGPFWSVHRYN
DIIDVEIDHATFSSDVKYGGMLIKDLPENMRRTSFINADPPLHDHQRRVVSPIVAPGN
LNRLEHTIRREAADILDGLPRGETFDWVDNVSIELTGRVLCELMDFPRADRRLLTYWS
DIVNVDLEVGGEINTEEKRYVKLKECASYFGVLFKERMNSEPKDDLISMLAHSEYTKN
MPEQEFLGMIVLLMVGGNDTTRNSISGGLVALNQFPEQYAKLHNDPGLIPKLVPEILR
WVTPVTHMRRTATRDIEFRGKQIRQGDKVVVWYASGNRDSDVIKDPYQFIIDRANPRL
HLSFGFGIHRCLGNRLAELQLRVLWEEILKRQMLIEMMGEPVRKYANNITGVMALPVRIAA

CYP153A11  Sphingomonas sp. HXN200 
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 7/20/2004
           80% to CYP153A8 62% to 153A2
           clone name P450-C

CYP153A12  Alcanivorax borkumensis
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 7/20/2004
           66% to CYP153A1 94% to 153A13
           clone name AP1-A

CYP153A13  Alcanivorax borkumensis Strain AP1
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 7/20/2004
           68% to CYP153A1 94% to 153A12
           clone name AP1-B

CYP153A13a Alcanivorax borkumensis Strain SK2
           GenEMBL AY505118.1
           Jan van Beilen
           Submitted to nomenclature committee 7/21/2004
           Nearly identical to CYP153A13 from strain AP1
           Two genes in this strain code for identical proteins
           SK2 Abo_193 and Abo_2132 
           Protein seq for both is shown below
MSTSSSTSNDIQAKIINATSKVVPMHLQIKALKNLMKVKRKTIGTSRPQVHFVETDLPDVNDLAIEDIDTSNPFLYRQGK
ANAYFKRLRDEAPVHYQKNSAFGPFWSVTRYEDIVFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRRAVQ
GVVAPKNLKEMEGLIRKRTGDVLDSLPLDTPFNWVPVVSKELTGRMLASLLDFPYDEREKLVGWSDRLSGASSATGGEFT
NEDVFFDDAADMAWAFSKLWRDKEARQKAGEEPGFDLISMLQSNEDTKDLINRPLEFIGNLALLIVGGNDTTRNSMSGGV
LALNQFPEQFEKLKANPKLIPNMVSEIIRWQTPLAYMRRVAKQDVELNGQTIKKGDRVLMWYASGNQDERKFENPEQFII
DRKDTRNHVSFGYGVHRCMGNRLAELQLRILWEELLPRFENIEVIGEPERVQSNFVRGYSKMMVKLTAKK

CYP153A13b Alcanivorax borkumensis Strain SK2
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 7/21/2004
           Nearly identical to CYP153A13 from strain AP1
           Two genes in this strain code for identical proteins

CYP153A14  Mycobacterium marinum
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 7/20/2004
           71% to CYP153A1 

CYP153A15  Hyphomonas neptunium
           gnl|TIGR_228405|contig:1062
           Found in the genomic blast server at NCBI
http://www.ncbi.nlm.nih.gov/sutils/genom_table.cgi
859136 MAADTVSFVNHPALERPKVTEREPLHPHNLRFGANIPPAADIDLSTLDLIDGELWRQGKY 858957
858956 WDRFERLRNEDPLHYCPDSFPGPFWSVTRYEDVMAIDTDHKRFSSSWEYGGITLGEPISD 858777
858776 FEMPMFIAMDEPRHSEQRKTVQPAVAPDMLKVYEPLIRSRTQGLLDSLPVNEPFDWVDKV 858597
858596 SVELTTMMLATLFDYPFENRRDLTHWSDVATGMHNPDICPGGEEEWKATMMKCLMTFMGI 858417
858416 YQERQQQPQKPDLMSLLAHGEKTKNMTPMELLGNVILLIVGGNDTTRNSMTASVFALNKF 858237
858236 PKEYEKLKADPSIIPNMVSETIRWQTPLAYMRRTALEDVEMHGKTIKKGDQVAMWYVSAN 858057
858056 RDERFWDKPNDFIADRPEARRHISFGFGIHRCVGNRLAELQLRILWEEIMERFEHIEVLA 857877
857876 EPSLNQNAFVKGYNWMPVVLHPK 857808

CYP153A16  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3154
           67% to 153A1

CYP153A17   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            59% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
            57% to CYP153A29 Parvibaculum lavamentivorans DS-1 CP000774 
            REGION: 1935500..1936753 protein ABS63400
            Ectocarpus sctg_1 1458016-1459287

CYP153A18   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            57% to CYP153A2 Caulobacter crescentus at C-term
            70% to seawater bacterial sequence CYP153A25 JCVI_PEP_1096681995831
            Ectocarpus sctg_1 2416172-2417446

CYP153A19   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            59% to CYP153A8 Sphingomonas sp. HXN200
            Ectocarpus sctg_1 2455477-2454218

CYP153A20   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            58% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
            63% to Parvibaculum lavamentivorans DS-1 
            CP000774.1 REGION: 2309535..2310806
            Ectocarpus sctg_1 2456749-2455490

CYP153A21   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
            Ectocarpus sctg_1 2728336-2729601

CYP153A22   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            71% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
            Ectocarpus sctg_1 2729680-2730936

CYP153A23   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
            Ectocarpus sctg_1 2731016-2732278

CYP153A24   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050
            Ectocarpus sctg_1 2732360-2733622

CYP153A25   seawater sequencing J. Craig Venter Institute
            JCVI_PEP_1096681995831 
            70% to CYP153A18
MSIHPEIDNSSGPLRELDVSLPEHYENDTWRPMFARLRKEAPVHYLSDSVNGPFWSVTSHALIKEVDANNSIFSSEKGGI
SIVDLKPVEGQVQGKNFIAMDEPEHSIQRSAVAPSVAPKNLVELEPLIRERAVDILENLPVGETFNWVQEVSIELTARML
TTILDFPYDQRHKLVQWSDLATDVPQVTGKEGTDMQARYDELMNCAAAFYQLWVSKSGQPPSFDLISMLQNNPDTARMNE
DMELFLGNMLLLIVGGNDTTRNSISGGVMALNQYPDEYQKLRDNPALIPNMVSEIIRWQTPVIHMRRTALEDYELGGQHI
KKGEKVIMWYLSGNRDESVFEDPDRLIIDRPNARSHVAFGFGVHRCMGNRMAELQLRVLWEEIMERFHTIEVVGDITRLP
NNFIRGIKEVPVRVHAH*

CYP153A26   Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS61648.1 (protein)
            CDS  27133..28401 locus_tag="Plav_0025"
            73% to CYP153A2 Caulobacter crescentus
MSDAAVKYEADEARDEAYSIPLAEINVADPSLFRDYKMWPYFERLRAEAPVHYSQGNEDTGPYWSVTRYN
DIMSVDTNHQVFSSEGGITLRDQDEDFKLPMFIAMDPPKHDDQRKVVSPIVAPGNLAKLEGTIRERAGKI
LDELPTGEPVDWVDRVSIELTTQMLATLFDFPFEERRKLTRWSDVATATEESGIIESEEQRRAELLECAE
YFMGLWNERVNAREPGNDLISMLAHGESTRNMDKMEYLGNLILLIVGGNDTTRNSISGGLYALNKFPDQY
KKLLANPGIIPNMVPEIIRWQTPLAYMRRTALQDAEVGGQTIRKGEKVAMWYVSGNRDESVIQNPNELVI
DRERPRQHLSFGFGIHRCVGNRLAEMQLRIIWEEILKRWDQPIRVLSEPQRVHSSFVKGYEKMMVELPKR
KH

CYP153A27   Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS63384.1 (protein)
            CDS  complement(1917064..1918329) locus_tag="Plav_1765"
            68% to CYP153A2 Caulobacter crescentus
MSETLVAARDKSIADAYAIPLEKIDVSNPELFRANAIWPYFERLRREDPVHYCKESEYGSFWSVTKYKDI
MHVDTNHGIYSSEATLGGVALRNQEEGFFLPMFIMMDPPKHDAQRKVVSPIVAPGNLAKLEGTIRERAGN
ILDSLPVNETFDWVDRVSIELTTQMLATLFDFPWEERRKLTRWSDVAAAGTAFGDEETEKARRNELRDCA
AYFTELWNQRVNATEPGNDLITMLAQGEATKNMGPMEYLGNVLLLIVGGNDTTRNSITGGLLALNENPVQ
YKKLRDNPSLVESMVPEIIRWQTPLSHMRRTALQDTELGGKQIKKGDKVVMWYVSGNRDEEAIENANSFI
IDRKHPRQHLSFGFGIHRCVGNRLAEMQLRVVWEEILKRWPDKPIEVVGEPTRVFSNLIKGYSSMPVRIPG

CYP153A28P  Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) 
            CDS 1927820..1929084 locus_tag="Plav_1775" 
            67% to CYP153A2 Caulobacter crescentus
1927820 MSSMNVAERVQSLDDPYAIPLDKLNVSDPELFRSNRMWPYFERLRREDPVHYCAESAYGPFWSVTK  1928017
1928018 YKDIMHVETNHGVYSSDVEQ  1928077 (frameshift)
1928077 GGITIRDNNAGLKLP
1928122 MFIAMDPPKHDAQRKVVSPIVAPANLAKLEGTIRERAGKILDSLPVNETFNWVDRVSIEL 1928301
1928302 TTQMLATLFDFPWEERRKLTRWSDVATSEEAFKTPEGEAAREAELLECAAYFTELWNQRV 1928481
1928482 NATEPGGDLITMLAQGESTKNMSPAEYLGNVILLIVGGNDTTRNSLTGGLLALHE 1928646
1928647 NPDQYRKLRENPALVETMIPEIIRWQTPLTHMRRTALQDTELAGKRIKKGDRVVMWYVSG 1928826
1928827 NRDEEAIDEPNRFIIDRARPRQHLSFGFGIHRCVGNRLAEMQLRIVWEEILKRWPDKPIE 1929006
1929007 VVDEPKRVFSNFIKGYEALPVRIPG* 1929084

CYP153A29   Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS63400.1 (protein)
            CDS 1935500..1936753 locus_tag="Plav_1782"
            73% to 153A8
            temporarily named CYP153A26 but revised to match 
            genome order of P450 genes
  1 MTTDTLVGDT ASTVPLSQMD VSDPKLFQSD MIGSYFARLR REDPVHYCPE SAYGPYWSVT
 61 KFNDIMQVEV NHQTFSSEAK LGGIALQDMQ SGEAALELEM FIAMDPPKHD AQRKAVSPAV
121 APSNLVLLEP IIRERAGIIL DSLPIGEEID WVDRVSIELT TMTLATLFDF PWEERRKLTR
181 WSDVATSTPE TGVVSSFEQR REELLECAHY FKGLWDQRVN EPPKPDLISM MVHSPATRDM
241 PYLEFLGNLI LLIVGGNDTT RNSISGGVLA LNQNPAEYRK LMADPDLIPK MIPEIIRWQT
301 PLTHMRRTAL MDAEIGGKKI RKGDKVVMWY LSGNRDDEVI DRPNEFIINR PNSRHHLSFG
361 FGVHRCMGNR VAELQLRIIW EEILKRFSKV EVVGAPERTL SNFIRGFTHL PVKLYVH

CYP153A30   Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS63566.1 (protein)
            CDS  2129237..2130550 locus_tag="Plav_1951"
            58% to CYP153A29 Parvibaculum lavamentivorans DS-1
            54% to CYP153A2 Caulobacter crescentus
MSEQVSVGRDYTRSNADLAAKWKIDVNRDPWSIPLEELDPAHDELFAANTVLPYFERLRKEDPVHLNETG
PYGRYWSVTKYEDIMHVDTNHKIFSSDIRNGGIRLGGQRIEGEPDPLTYLPMFIMEDPPKHDEQRKAVQP
MFTPQNLADLEPLIRERAGLILDALPRGETFNWVRQVSVELTGRTLATLFNVPQEDRHKLIHWSDTVERL
GDPEYFETPEEGFKELWNCWEYFDGVWKDRLANPGSDLISLLAHSPSTKNMPPNEYLGNMLLLIVGGNDT
TRNSITGGVLALNQYPDEYAKLIANPDIIPNMVSEIIRWQSPVAHMCRTATEDTELGGKKIRKWDKVAMW
YVSGNRDDSKIDRANEFLIDREGARHHLSFGFGIHRCIGNRVGEMQLRILWEEIMKRFKKVEVVGDPKYL
RSNFIRGITELPVIVRE

CYP153A31   Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS63742.1 (protein)
            CDS  complement(2309535..2310806) locus_tag="Plav_2128"
            64% to CYP153A2 Caulobacter crescentus
            77% to CYP153A7 Sphingomonas sp. HXN200
MTATASAAAPAGIDDPYALSLDQIDVSKPELFERNAEGAYFARLRREDPVHFCADSAYGPYWSITKYKDI
MAVDTNHQVFSSEAGLGGIIIEDGIQKSSGEGSIDLPNFIAMDPPKHDGQRKAVSPIVAPANLANLEGTI
RERVGRVLDGLPVGEEFDWVPAVSIELTTQMLATLFDFPFEERSKLTRWSDVATAEPGSGIVDSWEQRTS
EIMECAECFQGLWNERMEKPGMDLVSMMAHSPATHDMTPQNYLGNVLLLIVGGNDTTRNSMTGGVLALHQ
NPAEFAKLKANHGLIDSMVSETIRWQTPLAHMRRTALADAEVGGKTIRKGDKVVMWYVSGNRDKDVIIQP
DDFIIDRERPRQHLSFGFGVHRCVGNRLAEMQLKILWEEILKRFSRIEVTSEPVRTRSNFVRGYASMPVR
LHA

CYP153A32   Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            82% to CYP153A16  Mycobacterium marinum

CYP153B1X   Bradyrhizobium japonicum USDA 110
            Renamed CYP153A9

CYP153B2X   Bradyrhizobium japonicum USDA 110
            Renamed CYP153A3

CYP153B3X   Bradyrhizobium japonicum USDA 110
            Renamed CYP153A4

CYP153B4X   Bradyrhizobium japonicum USDA 110
            Renamed CYP153A5

CYP153B5X   Bradyrhizobium japonicum USDA 110
            Renamed CYP153A10

CYP153C1    Novosphingobium aromaticivorans
            GenEMBL NZ_AAAV01000116
            complement(18298..19530) gene = Saro1194
            45% to 153A5
MAATLAPDRAINPHDVSLNALYTEDRWREPFRWLRENMPVSYRA
ESPFGAYWSVVTHDLIQQVELDPGTYSSSWQRGNITIADSVNETEFPNFIAQDPPIHT
AQRKVIAPAFGPSQMVKLERLVRERTTQLLDGLPMGEEFDWVERVSIPLTLGMLLILF
DMPFDEWRDIKRWSDWASGVSEDSLNDAYRAEFVQQMGQMLMRFDRELEARRALPPSD
DLLSRMVHSDAMGHLTPPERIANIALLIVGGNDTTRNSMSGLIEALHRYPAELDKLRA
DPALSANAAQEIIRWQSPVTHMRRTLTRDAELGGQRLAEGDKIVMWYISGNRDENVFP
DAERFDVTRENARRHIGFGHGIHRCVGARLAEVQIAAVIEEIATRRLRITPQGAPTRL
ASPFLHGFTAMPVVMSRD

CYP153D1   Novosphingobium aromaticivorans
           NZ_AAAV01000178 
           4242..5579 gene = Saro3794
           47% to 153C1
MATQLAPEVPQFTYHSSPTATEAFAAWLKDNPQAIPAHSHPWDV
SRSDIYVEDRWQPIFAEMRAKAPVNRVPDSPYGAYWNVASHKAIMHVESLPELFSSSW
QYGGITIGDPPEDVDPQKLAERQLPMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEI
RRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWAGDVEL
TLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGN
LVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLIPNAVQECIRYVTPLAHMR
RTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNARRHLSFGHGIH
RCVGARLAELQLRILLEEMHERRMRVRVAGEVERVRANFVHGFRKLEVELEKR

CYP153D2   Sphingomonas sp. HXN200 
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 11/27/2003
           55% to 153D1
           clone name P450-D

CYP153D3   Sphingomonas sp. HXN200 
           No accession number
           Jan van Beilen
           Submitted to nomenclature committee 7/20/2004
           59% to CYP153D1 68% to 153D2
           clone name P450-B

CYP153E1   Erwinia chrysanthemi strain 3937
           gnl|TIGR_198628|NC_003916 
           Jan van Beilen
           Submitted to nomenclature committee 7/21/2004
           Found in the genomic blast server at NCBI
http://www.ncbi.nlm.nih.gov/sutils/genom_table.cgi
4874678 MKMTKQLQDVFEDIDAVPLEKINPASRDRFINAAELPMFERLRREDPVHFTPESEFGPYW 4874499
4874498 SLTLWEDIRAVGNNYRDFTSTQNIDLKSIEEKIKLEAALQALGHERRKNVGFITMDPPEH 4874319
4874318 TKHRKAVTPAVGPSSLAQMEPIMRERAGIILDSLPIGEPFDWVDLVSKELTATVLATLLD 4874139
4874138 FPFEERRKLTFWSDLLMFEPGHGLVKSWEQKAEETVKCYQVFEALWEKRRNGPPSYDLIS 4873959
4873958 MLAHHPDTRDMTLEQFRGTIVLLIIGGNDTTRNTISSSLYLLDKYPEEFAKLKANPKLVM 4873779
4873778 PMISETLRFHPPVNFMSRVATRDVEIRGKNIKEGDRVVMWYTSGNRDASAIEDPDTFSID 4873599
4873598 RERARRHLSFGVGVHACIGSRVAEMQLTVIWEEILKRFSRIEVLEEPERSYSNFLHGFEN 4873419
4873418 LKVII 4873404

CYP154A1    Streptomyces coelicolor cosmid E6 
            GenEMBL AL353832 CDS 17561..18787
            51% to AF145049 42% to AL158061 complement(14764..15987) 
            38% to 107A1, 107B1 39% to AF087022
            cloned and expressed by David Lamb and Steve Kelly

CYP154A2   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV109 70% to 154A1 from Streptomyces coelicolor

CYP154A3   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           75% to 154A1
           clone name SP0673

CYP154A4   Streptomyces scabies
           SCAB20211
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           57% to CYP154K1 Streptomyces rochei
           58% to 154A1 Streptomyces coelicolor, note 154K1 is 52% to 154A1

CYP154A5   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1147
           58% to CYP154A4 Streptomyces scabies SCAB20211 
           missing about 34 aa at N-term

CYP154A6    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE7009 67% to CYP154A1

CYP154A7    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6527 65% to CYP154A4

CYP154A8   Nocardia farcinica
           YP118504
           62% to CYP154A4 Streptomyces scabies

CYP154B1   Streptomyces fradiae tylosin-biosynt. 
           GenEMBL AF145049 CDS 3108..4409
           51% to AL353832 CDS 17561..18787 44% to AL158061    
           complement(14764..15987)
           39% to 107C1

CYP154B2   Streptomyces avermitilis
           GenEMBL AP005036
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV3704 64% to 154B1 from Streptomyces fradiae 
           A tylosin-biosynthesis gene in fradiae

CYP154C1   Streptomyces coelicolor cosmid 6D11 
           GenEMBL AL158061 CDS complement(14764..15987)
           44% to AF145049 42% to AL353832 CDS 17561..18787 39% to 107C1 
           cloned and expressed by David Lamb and Steve Kelly

CYP154C2   Streptomyces avermitilis
           GenEMBL AP005036
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV3882 87% to 154C1 from Streptomyces coelicolor

CYP154C3    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1085
            58% to CYP154C1

CYP154C4    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR3108
            74% to CYP154C2

CYP154C5   Nocardia farcinica
           AP006618.1 5611314-5612546 (+) strand
           67% to CYP154C3 Streptomyces griseus

CYP154D1   Streptomyces avermitilis
           GenEMBL AP005026
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV1308 47% to 154A1 from Streptomyces coelicolor, 
           46% to 154B1, 45% to 154C1

CYP154D2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_870
           70% to CYP154D1 Streptomyces avermitilis  

CYP154D3    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE5553 59% to CYP154D1

CYP154D4    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2869 68% to CYP154D1

CYP154E1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000039b 
            99628..100836 gene = Tfus2243
            49% to NZ_AAAQ01000042a   154F1
            47% to NZ_AAAQ01000029a   154G1
            46% to 154D1
MGQSRRPHTVYLDPAKGVDIPAQRRELLDKGPVVRVAFPGNLEV
WALTHDAPLRNALADESVFVRGWRNWRALMAGEVDPTHPVANMLRVESMLARSGADHK
RMRGLVQAAFTRRRVEALRPRIEEITNELLDRMAESDGVVDLKAAYSFPLPIRVISEL
LGLNEEDHLTLQTLVTRTLSGTDPEANADAFTFVASLIEAKRKNLDDGLISAMIEARA
EDGDRLSETELIHNTLLLIIGGFETTMGMISNSVQLLLTHPDQLHLLRTGQASWENAI
EECLRFESAVVMLPFLYTTRDVEIDGITIPAGDAVLIGFGPANRDPQAYDDPDRFDIT
RPRPRHLAFGHGAHLCLGAALARLELLIALPALFERFPDITLVGEAPPTPTVFMNHPL
SRPVLLRPKP

CYP154F1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000042a 
            complement(347138..348745) gene = Tfus3014
            49% to NZ_AAAQ01000039b 154E1
            44% to 154C1 and 154C2
            N-terminal extension may be incorrect
MAVSADHAAAGALPGARHPAGRRVRAGRRLLDHRLRSGTRRPGG
CPVHRPAQPVRDPRPPGVGDRAPRVPGAADLPADRGRRGECAAGPVAGRASRGSPRVA
GAAPFPVRPRTQGASCHLHPRRHHPTNGGT

MAAVPEPIVLVPGKSREQALQLREAGPL
ARVVVEGLEVWALTHDRELREALIDPRFRRNWRTWRALNEGEVATDHPVAAMVYLDNM
LTVDGEAHRRMRSPVAQAFTPRRVELLRPRVTEIVNALLDQLAERDGTVDFKTEFAYP
LSMRVFSALFGIPERDHGRMQQMVNTAFSPSSPEEVRAMREELDAFLDELIEDKRRSP
GEDLTSALVTATDEEHKLSDAELRDTLWLLVTAGFETTSSALANAVQTLLTHPDQLAH
LRSGSIAWEDAIEEVLRQSSSVATLPFLFAAEDVQIGDRTIRAGEPVLLAYLAANLDV
ERYGEDAAEFDATQSRPRHLAFGHGPHTCLGAALARLEMEVALTTLFTEFPEVSLAEG
EAPRLESVFIHAPAALPIRLGPRRTAA

CYP154G1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000029a 
            complement(12913..14079) gene = Tfus0891
            47% to NZ_AAAQ01000039b 154E1
            41% to 154C1
MLDTERGLTEADIHALAEHGPVVRLSVMGLDVWAVTGYEELRTL
MADPEVKRGVEHWTAVAQGKVPAEHPLVKLVSMGSMLSKNPPEHTRLRRLVQHAFTTR
RVEGLRPVVQELTRACLDRIDASQPFDINAALSHPVPVGVIGRLLGIPETDQPALDSL
VTRLLSGTDATVHEELYAYVAAMVAARREQPDDGLISALLHVHDDDGSTLSEEDLMWT
VVLLVDAGFETTVGQISNSVRLLLEHPDQLALVTSGEVPWERAVEECLRHTASVVMLP
FCFPTREKELGGYTIGAGEPVMMVYGAANRDSRVHAAPKVFDVTRSDSRHITFGHGPH
HCLGAPLARLELNVVLPELFARFPKLALAERDIPRVKSLFVNRPSELWVTAGMG

CYP154H1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000035b 
            93951..95183 gene = Tfus1569
            51% to 154C2
MMASPTDNPIVLDPYVSDLEGERERLYEAGPIAWVELPGGVRTW
SVTHHQAARELLTDSRLSKNMAHWGAYNRGEISPTWPLLSVIPPTPTNLLGTDGAEHK
RLRTLTAQAFTPRRVEKLRPRIREITEELLDALEERANEPQDLKSEFSFKLPMRVIGE
LYGVEEAAHGQLRSLYDKFFSSVTPPEEFLATREALVQFYTELMERKKANPSDDLTTA
LLQANENGDRMTDEEVLGTLQIVVAAGHETTVNLLTNTVRALLRFPDQLELLRTGKAT
WEAAIEESLRWDPPTTNFIFRFATEDIEYGGVTIAKGDSVMISYGAIGRDRGQHGDNP
EVFDVTRKTSSRHISFGYGPHVCPGAPLARLEAQVALPMLFERYPDMKLAVDDSELVP
NPSVIVNSLKEFPVILRP

CYP154J1    Streptomyces carzinostaticus subsp. neocarzinostaticus
            GenEMBL AY117439 
            complement(35390..36622)
            47% to 154B1
MCPYRLDPEGADTHGETARLREQGPIARVELQDGVLAWSVHDYA
VAKQIMADERFSKNPRKNWPAYINGEISNGWPLITWVAMDTMATQDGADHARLRKLLL
KAFTERRVESMRPHIEKTVKELLDNMAAKADDEIVDIKEMFHAELPTRLMCDLFGVPE
ERRAEVLAGGHKNIDTRISSEAAEANLGQWQEAISDLVEYKRHHPGDDLTSALIEARD
EGSRLSDSELIGTLHLLLGAGSETLVNALAHSSLALLVDADLRKKVTSGEIPWVNVWE
ETLRVESPVAHLPFRYATEDFEIGGVKISKGDPLLVDFAGIGRDPAVHSDAPDEFDAL
RPDKTHLSFGHGVHYCLGARLAKHAWMIGIPALFERFPDMELAVRRDELKGQGSFVVN
GHASLPVHLKGRAAALAR

CYP154K1   Streptomyces rochei plasmid pSLA2-L
           NC_004808 complement(144081..145325)
           53% to 154B2
           note = ORF84 
MLRQEAPYVIDSAGRDLPGEAARLRERGPVVRVVLPGGVSAWAV
TDLDLIKQLLTDSRASKDAYRHWPAWAGGEVDESWQMSMWVSVRNMLTAYGEEHARLR
RLVAGAFTARRTADLRPRVERITARLLDGLAAVPPGAAVDVRNEFARPLSVLVMGETL
GLPEDLHADLQRMVDVLFKTTAEPEEARANQYELYALLTELVAARRSAPGTDLTSELI
AARDEDGGEGLSEKELVDTLLLLIGAGTETTVNLIDQAVHGLITHPAQLALVLGGEAT
WDSVIDETLRHQPVVANVPFRFAVEDIEVGGVTIPKGDPILLSLAAAARCPHRHGADA
DQFDVARPSRRDHVPFGYGVHHCVGRPLARLEVSIALESLFARYPRMAAAVPEAELAV
RESFISSGHVALPVVLVPGAAA

CYP154L1   Streptomyces scabies
           SCAB32131
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           49% to 154A1, 47% to 154B1, 47% to 154K1

CYP154M1    Salinispora tropica (marine actinomycete)
            Strop_2724 complement(3069331..3070560)
            51% to CYP154J1 Streptomyces carzinostaticus
MRRRCPVVIDPAGTDIHAEGARIRANGSVSQVELPGGVLAWSVTGQQVARKVLSDQRFSK
DPRKHWTDYLEGRIGQDFPLIGWVLMDNLTTAYGSDHSRLRKPCANAFTPRRVEALRPAV
ERAAVELLGELATVSPTESVDLKARYAHPLPSRVICDLFGVPEEDREEMLRGGEVNVDTR
VSAEEAAANVERWHQQMLDFIEEKRRNPGPDLTSDLIAAQQAEGSRLTDSEMVGTLHIML
ATGTEPVKNLIGNAVFALLTHPEQLDLVRSGRAGWDDVIQETLRMQAPVAHLPFRFAVED
VDIDGVTIRRGDPLLVNFAAIGRDPDVHGDTAAEFDITRADKEHLSFGHGVYRCIGQPLA
LREAEIALRMLFQRFPNLVLAVPPEEVTPQPTFIMNGLDTLPVLLKGRA

CYP154M2    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR622
            69% to CYP154M1

CYP154M3   Streptomyces ghanaensis ATCC 14672
           GenPept EFE72442.1

CYP154N1   Frankia alni ACN14a
           YP_711761.1
           CAJ60170.1
           52% to CYP154L1 Streptomyces scabies
MVHVQPLSVAAAGPSLVAEAAALRARGPVAEVTLPGGIPAYAVNEHALLRALLLDPRVSKDPRRHWAQWD
EACRRPEWGWVLQWVGVVNMLSTYGVDHARLRRLVAPSFSARRTELLRPAVVAVTERLLDDLAAGSARAA
GSAGSVGSVGSVGSAGSVGSAGSVGSARSVGSAGSAGSVVDLVGTFAQPLPLAVISGLFGIPDRMRPDFA
HVVEQIMNTTVSSEQAAANLGRTRSVLATLVERKVREPGDDLTSELIGVRDAVTGDRLAHRELLDTLLLL
ISAGHETTRHLLGNAVHALLTHDRQLRRLRAGEITWDQVVEETLRWAPSIANIPLRFAVTDIDTGAVTIP
AGAAIVAGILAAGHDPGHHGPGASRFEPGRDAADHLAFGVGVHRCLGAPLARLEAGYALPALFARFPGLA
LATPADDLPQAPSFIVHGWQALPVRLAPPAPLVTASAR

CYP154P1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1935
           43% to CYP154D1 Streptomyces avermitilis 
           41% to CYP154H1 Thermobifida fusca

CYP154P2    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY842 70% to CYP154P1

CYP154Q1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6952 

CYP154R1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY5125 

CYP154S1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY1366

CYP155A1      Streptomyces coelicolor cosmid 6D11 
              GenEMBL AL158061 CDS complement(40542..>41807)
              32% to AF127374 new family
              cloned and expressed by David Lamb and Steve Kelly

CYP155A2    Saccharopolyspora erythraea NRRL23338
            SACE_3189, se: 3523366,3524559 (-) STRAND, 
            63% to CYP155A1, 47% to 155B1
MPTDSTDARKIDRGETEGGCPVHRRPDGVWEVRGYASARAVLRSTDTVQAGLGVETVEKM
PSRIRRPVLYRDGTEHREHRRQTARYFTPRRVDEHYRDIMERVTDEQLAKLRADGRAQLS
ELSFHLAIDVASSVIGLTESKPGIQARLERFFPEEFGEPGFTSINGIYWIFRQLRNWLGI
YLGDVRPAVRARKRRRQDDLISHLLDEGCSSAEILGECITFAAAGMVTTREFVNLAAWHL
FTDEALRERYRSAEEAERLEVLHELLRLEPVVGHLRRRTNAELRVPDGDSEVTVPAGEVV
DIVVSATNLDERVMGEQPASLCPGRELSDGAYAHGMSFGDGAHKCPGAHIAILETDTFLR
KLFALPGVTMETPPRVTFNDAIGGYELRDLVVSVSAN 

CYP155A3    Frankia sp. CcI3
            YP_481069.1
            ABD11340.1
            not like Frankia alni P450s same as |ABD11340
            58% to CYP155A2 Saccharopolyspora erythraea 
MADPVVTDVGTSARKIDREDPNGGCPVVQGADGVWRISGYAAGQAVLRSLETKQAGLGIDASKAIPKRIR
RPVLHSDGPEHRERRRLTARFFTLRRVDEHYRELMHRVADEQIDRLRRERSVDLSELSFALAVEVAAAVI
GLTNSRPGMAARLERFAQGDLGPPNVTSIRGIRQFIRQNRHALAFYLADVRPAVRARRRRRTDDLISHMI
DQGCTNAEIFAECVTFAPAGMITTREFINVAAWHLFTDDTLRARYHDADQTERIAILHEFLRLEPVISTL
KRRTTADIQLPGPHGPLTIPAGAQIDIAVSSTNIDTQAIGADPYTVRPARPIGDGVSPAGLSFGDGPHKC
PGAHVAIHETDIFLHKLFMLDGLHMASPPQVTLRDEIAAYELRGLVVTLD

CYP155A4   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1967
           68% to CYP155A2 Saccharopolyspora erythraea NRRL23338

CYP155B1   Deinococcus radiodurans
           NC_001264 192795..193784 
           frameshifted C-term, frameshift not a seq error
           43% to 155A1 
MPSFLSFRSSAMTAHDAQPEPARCPFTGQAAPTETITRRHVPPQ
GDLAQPVETYARARDLLKSEQAQQAGFLADMVSRVPGSQHPPVLYLEGEEHTEMRRAT
AKYFTPTQVNTYQPDIARLADELIGKLARRGEAKLDDLSLELAVRVAAGVVGLTNSRL
PGMDRRIERFIPSGVDAEPGVKLEGASPLENARQAANMALFYALDVKPAIEARRKAPQ
DDLISYLLSRGYNDQDILTECVTYGTAGMITTREFISVAAWHLLKNPELRAAYVHGTE
KERHAVLHEILRLEPVVGTLYRRA
GTGDDCGRRSHPAGSVFALDIGQANLDPAVMGEGAEQLCPMRELPRGVQAQGLSFG
DGHHRCPGAFLAIKETDVFLRRLLIWNDLHVVSEPRVTYNEVIKGYELRGFRVRLGGARA*

CYP155B2P   Deinococcus radiodurans
            GenEMBL NC_000959 73..384 
            plasmid CP1
            44% to 155B1
            C-term only runs off end might be a full gene
SGSTDAEILPYVVEAEPSSPVVHLDISQ
ANRDESVFTQAQQFCPHRKNVRQHLSFGKGEHACLGQSLVYTICRVMAHALELLSAPAGQ
RTDQVSQ*

CYP155C1    Brevibacterium linens strain ATCC 9175
            GenEMBL AF139916
       Krubasik P, Sandmann G.       
       A carotenogenic gene cluster from Brevibacterium linens with novel
       lycopene cyclase genes involved in the synthesis of aromatic 
       carotenoids.
       Mol Gen Genet. 2000 Apr;263(3):423-32.
            87% identical to CYP155C2
            complement(9188..10417)
MNSVSMRKAVGTHDETEPRVGHDGTMWRIRSYEAATTVLRARHQ
TTQAGFTAEKIPRGYFRQHPILISDGDDHDVQRREVARYFAPAVVSAKYGDFINKRAQ
ALVDSALANGRLRLDEAALNYSVEVTAEIVGLTDSPIDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWIQAAVNGLVPIGRFYISDVRPAIRARRDRRRDDVLSHLLSAGYSTADIL
VECVTYGTAGMVTTREFITMACWHLLTNDELGRRYTEASQPTRLEILEEIIRLDPVVG
HLYRRAQADIEVSDNGCPYTIPEGDLIDVCVRQTNTDPQAMGAAPETVIPGRDLRRGS
AATGLSFSDGAHTCPGQPLALYETDALLHKVLATRPRILREPTISWDNVIEGYRLRGL
DLSLMTRSRPVTTRMTT

CYP155C2    Brevibacterium linens strain ATCC 9174 (JGI genome project)
            Version 09sep02 - Scaffold2 Gene 3393
            This sequence is 40% identical to CYP155B1 from 
            Deinococcus radiodurans NC_001264 192795..193784.  
            It is about 37% to CYP155A1 AL158061.1 Streptomyces coelicolor.
MNSAGMRKAVGAHDETEPRVEHDGAMWRIRSYEAATTVLRARHRTTQAGFTAEKIPRGYFRKHPILISDGDEHDSQRKEV
ARYFAPAVVSAKYGEFINERAQALVDRAVANGGLRLDEAALNYSVEVTAEIVGLTESSTDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWAQAAVNGLLPIGRFYVHDVQPAIRSRRSRRRDDVLSHLLSAGYSTADILVECMTYGTAGMVTTREFITMAC
WHLLTDEELGRRYTESSQPTRLKILEEIIRLDPVVGHLYRRAQADIEVSDNGCPHTISAGDLIDVCVRQTNTDPHAMGTA
PETIIPGRDLGRGTAATGLSFSDGAHACPGQPLALYETDALVHKLLTIGPRILRKPEISWDNLIEGYRLRGMDLSLMERS
RPAATREPI

CYP155D1    Frankia sp. EAN1pec
            YP_001507958.1
            ABW13052.1
            41% to CYP155A2 Saccharopolyspora erythraea
MTTTELPKCPMDPTRDDRKSAALAAQRVRADAGARVVGSFDFGRAILRSATMLQAGAGSEQVKVGGDEHG
PVFFLDGEEHRRRRTAIARFFTPKAISTRHRLVMERTSDELLARLRAKGGGQLDELSYQLAVAVAAEIVG
LTDSNQVAMARRIQATLLGTRLRGMHPVIRVGAQALTAVHAMRFFLRDVRPAIRSRRRERRDDVISHLID
EGYPDKAILIECMTYAVAGMVTTREFIVMVAWHLFDNDELRARFTAGGEADQTAIIEEILRLEPVAAMLH
RRATQDSDLGVGSVKEGELLAVSIRAANVDPETVGECPHALDPDRARRLKAVGSYMSFGDGSHRCPGAQV
AINETRVFLDRLMRLPDLRLARTPDMTWCDGLMSYELRGATVTCSRDLTPAAHEVGQDAGPDGEQT

CYP156A1      Streptomyces coelicolor cosmid E6 gene 
              AL353832 16317..17549
              34% to AL158061 complement(15984..17225)
              cloned and expressed by David Lamb and Steve Kelly

CYP156A2    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE7011 67% to CYP156A1

CYP156B1      Streptomyces coelicolor cosmid IF3 gene 
              AL590982.1 10933-12276
              41% to 156A1
              cloned and expressed by David Lamb and Steve Kelly

CYP156B2   Streptomyces scabies
           SCAB79211
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           65% to 156B1

CYP156B3    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE4276 63% to CYP156B2

CYP156B4    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY3624 59% to CYP156B2

CYP156B5    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR3494
            59% to CYP156B4

CYP156C1   Streptomyces scabies
           SCAB20221
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           54% TO 156B2, 51% to 156A1, 50% to 156B1

CYP156C2P   Saccharopolyspora erythraea NRRL23338
            SACE_4886, se: 5459819,5460361 (-) STRAND
            56% to 156C1, 46% TO 156A1 AA 138-308
LINEFGSAGEADLLTQYAGPLTLRVLTWLFGCPTDLGQRLLADMAHIADAADAGAAGEAG
ADLDECLRRLVHLKRGHPGRGVTSRLMAHSAQLSDDEVVHQLVILMGVSGEAQQNLISNA
LRLLLSDERFAGDLSGGSLPVEDALDEVLWADPPIANHSTAYPTREVHLDGVHLPRVNRW 

CYP156C3   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1148
           57% to CYP156C1 Streptomyces scabies SCAB20221

CYP156C4   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1149
           59% to CYP156C1 Streptomyces scabies SCAB20221 
           80% to CYP156C3, 58% to CYP156C5

CYP156C5   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_5524
           58% to CYP156C1 Streptomyces scabies SCAB20221  
           60% without 16 aa insertion

CYP156C6    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6526 66% to CYP156C5

CYP156D1   Streptomyces scabies
           SCAB32121
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           41% to 156B1, 38% to 156A1

CYP156E1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_8426
           52% to CYP156C1 Streptomyces scabies SCAB20221 

CYP156E2    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY3639 64% to CYP156E1

CYP156F1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_8398
           56% to CYP156B2 Streptomyces scabies SCAB79211 
           missing N-term 165 amino acids

CYP157A1      Streptomyces coelicolor cosmid 6D11 
              GenEMBL AL158061 CDS complement(15984..17225)
              51% to AL132991 complement(7477..8739) 40% to AL132648
              cloned and expressed by David Lamb and Steve Kelly

CYP157A2   Streptomyces avermitilis
           GenEMBL AP005036
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV3881 86% to 157A1 from Streptomyces coelicolor

CYP157A3    Thermobifida fusca
            GenEMBL NZ_AAAQ01000035a 
            92419..93954 gene = Tfus1568
            55% to 157A1
MGPAVHRGARRSRPRRRPPTRRLLVLHRPAGGARHSLRRRPQQL
RVLLHPGPDPRGTRPGPLSPPPGMRRPGTRVRQTGAGHPGPTCDDDHRGGGRPMNAQR
GIPSSHQNAFRLYGPQFQNKPAELYRQMRTDYGPVAPVLLDGDIPAWLVIGYREVTHV
LNHPETFARSSRRWNAWDLVPENWPLYPMVTRTPNILYSEGEEHRRRATAISDALSGA
DQHEVRQYAVQAADRLIDGFCAASRADLRADYASRLPAIVLGRLYGLDQKHAEVLAEA
MTTMIDSGPDAVKAQQFLLQTMGTLVAERRKQPGPDVVSRLVHHPAKLRDEELIPDLV
VILGGGHQPTTEWLGNTLRLMLTDDRFAASLTGARSSVREALNEVLWEDTPTQIYLGR
YAAHDVELGGQLIRRGDLVLLGLAGANSDPQINPGPECRMSQGNQAYLSFSHGEHRCP
YPAPELAEIIVTAGIEVLLDRLPDVELAVPVDELRWRPSPWMRGLVALPVVFTPVPPI
GGQ

CYP157A4   Streptomyces scabies
           SCAB51111
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           71% to 157A2 Streptomyces avermitilis

CYP157A5    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6784 61% to CYP157A1

CYP157A6    Streptomyces cyaneofuscatus IT17-157 
            AB426723.1
            80% to CYP157A1

CYP157A7    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1086
            59% to CYP157A1

CYP157A8    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1086
            80% to CYP157A1

CYP157B1      Streptomyces coelicolor cosmid F55 
              GenEMBL AL132991 CDS complement(7477..8739)
              51% to AL158061 (15984..17225) new family
              cloned and expressed by David Lamb and Steve Kelly

CYP157B2   Streptomyces hygroscopicus subsp. yingchengensis
           AY260760 complement(2270..4150)
           P450 fusion protein
           83% to 157B1 C-term part
           gene = shy2
           note= fusion to ATP/GTP binding protein at N-term
MGSATSELPSQRTPLTAAAETGLKIVVVGGFGVGKTTLVRSVSE
IRPLNTEELMTQAGQGIDETAGVERKTTTTVAFDFGRISLNDRMVLYLFGAPGQERFW
FLWDRLFAGTLGAVVLVDTRRMEDCWYAIDRLEHHGTPFVVAVNRFDGDEKRFSLDEV
RQALALGEHVPMIECDARVRASGKEVLIALVDHLYTRALAKESTACSDTTGFPSTDAP

PPGCPAHGSAVPLAGLEYQQTPSQLYRTLRREHGAVAPVLLDGGIPAWLVLGYPEVCY
VTAHDELFARDSRRWNQWEHIPPDWPLLPYVGYQPSVLFTEGAEHQRRAGVITQALEG
VDQFELARECQLIAARLISSFSGSGRAELMSMYAHALPARGVLWMCGMPAEDADTERL
VDDLRISLDAGEGDDPVAAYTRVGERIMRLVKEKRERPGPDVTSRMILHPAGLGDEEI
VQDLISVIAAAQQPTANWICNTLRLLLTDERFAVNVAGGRVSVGEALNEVLWLDTPTQ
NFIGRWAVRDTQLGGRHIREGDCLVLGLAAANTDPQIWPEPHAGSGNSAHLSFSNGEH
RCPYPAPLLADVMARTAVETLLEHLPDLVLAVEPEELTWRPSIWMRGLTSLPVEFTPA
MN

CYP157B3    Saccharopolyspora erythraea NRRL23338
            SACE_1153, se: 1272726,1274018 (+) STRAND, 
            56% to CYP157B1
MTGASEVEWPAADAPSDCPVQEVPAAPQEHAVRMYGPILQRDPKELYREMRREHGPVAPI
LLEGDLPAWLVLGYREVHQVTTDSELFARNSRRWNHWDDVPEGHPLWPWLGIDHSVLVSE
GEEHRRRAGAISDALAAVDQFELWDHCARIADRLIDSFAGSGRADLIAEYTDRIPLLVVT
TMFGMTEEQTRNLIGDLSTTIDAAEGAGAAHNRVVDRMRALLAVKRERPGNDLPTRLLGH
PSTADDDECAIDLVILLTAAHQPTASWIGNTLRLLLTDERFALTLSGGRRSVGDALNEVL
WEDSPVSNLLGRWAARDTQLGGRAIRKGDLLLLGYNAANSDPQVWPDGTNAHMAGNHAHM
AFGHGEHGCPFPAPELAEVIAKSTIEVLLDRLPDLRLAVEPEALRWRQSTTIRGLVDLPV
EFSPTYAKRP

CYP157B4   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9885
           56% to CYP157B2 Streptomyces hygroscopicus subsp. yingchengensis

CYP157B5   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9382
           62% to CYP157B4
           53% to CYP157D1 Frankia alni ACN14a

CYP157B6    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE2761 69% to CYP157B2

CYP157B7    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE5134 57% to CYP157B6

CYP157B8    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY4504 79% to CYP157B5

CYP157B9    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR4392
            79% to CYP157B1

CYP157C1      Streptomyces coelicolor cosmid I41 
              AL132648 CDS complement(9396..10892)
              40% to AL158061 (15984..17225) 39% to AL132991 complement(7477..8739)
              cloned and expressed by David Lamb and Steve Kelly

CYP157C2   Streptomyces avermitilis
           GenEMBL AP005047
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV6706 70% to 157C1 from Streptomyces coelicolor

CYP157C3   Streptomyces griseus
           GenEMBL AB044803 3754..5328
           61% to 157C2
           gene = rarE
MTTPFHHEPGTVPPPQCPAHNLDIGPGGLRRLHGPEAENNPAGL
YDKLRAEHGTVAPILLHGDVPAWLVLGHSENLHVTRTPSQFSRDSRRWRALQDGSVAP
DHPLAPIFTWQPICVFADGPKHERQRGAVTDSMERIDTRGVRRHINRFSNRLVNDFCE
KGTADLVGQFAEHLPMMVVCAIFGMPEEYDERLVQAARDMTRGTETAVASNAHIVSVL
TRLVERRRAEPSPDLASWLVEHPATMTDTEVIEHLRLIMIAAYESTANLIANVLRMVL
IDPRFRARLSGGHMTVPEAVEQTLWDEPPFTAVFGRWAVGDTELGGQQIKAGDALLVG
IAPANTDPTVRPDLGADMGGNRAHLAFSGGPHECPGQDIGRAIADVGVDALLMRLPDL
ELGVGESELHWVGNIMSRHLVELPVKFAPGPQQKLDADPLTVMARLLAPPTPGRSPPR
PGRSPSPATRGPWRRAHAPGAAPTAEPDPAPAAPPAPEPAAAPEPAPVATIPQQRRPA
APARFWQAVTRWWSGY

CYP157C4   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           57% to 157C3
           clone name SP0618

CYP157C5   Streptomyces scabies
           SCAB73721
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           76% to 157C2

CYP157C6   Frankia sp. CcI3
           YP_483409.1
           ABD13680.1
           39% to CYP157D1 CAJ59158 same as YP_483409
           56% to CYP157C4 Streptomyces peucetius
MSTPIPEAGAESGAAIPPPGCPAHAAFAQDAVRTALYGPEAQHDPGAVYEKLRAEHGGIAPVELEGGVPA
WLVLGYRENMEVARTPSRFTRDARLWRDWNEGRIAADDPLLPLIGWRPDVVSYDGEEHARLRAAVNECLT
RFDRHGTRRHVQRYANQLIDGFVEDGRADLVTQFAVYLPMLVLSRLVGLSEGYGRKLVEAIVGMVSGGED
AYAHNQYIIGTLRSLTEERRRAPAHDLASWFVQHPSGLNDEEVLNHLRLVIVLGYEATANLVSNTLRMVL
TDPRFRASLAGGLMTLPDAVEQMLWDDPPLLVCPARFATHDMHFADKEIREGDMLLLGIAAGNADPEIRP
DLGAPMHGNRSHLAFSRGPHECSGQEIARAITDTGVDVLLNRLPDLHLTVPEEQLTWTASTWSRHLDALP
VKFAPQCRPVPQSAPAAPAFSAPVVEPSAAKDALAAVAEADAQARADTRRGFWASLGGMFRGRR

CYP157C7   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7811
           60% to CYP157C4 Streptomyces peucetius   

CYP157C8    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY1152 63% to CYP157C4

CYP157C9    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY8043 67% to CYP157C4

CYP157C10   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1059
            94% to CYP157C3

CYP157D1   Frankia alni ACN14a
           YP_710767.1
           CAJ59158.1
           55% to YP_001509751 EAN1pec
           54% to CYP157A2 Streptomyces avermitilis
MTPPSHDRVDTWAPAPAAPELAAPAPGFPDHPGAVRLYGPRFQHNPAQMYREMRRVHGPVAPILLDGDIP
AWLVLGYRELHYVTSNPELYGRDPRRWNAWDRVPPDWPLLPVVGYQPYTMHLEGAEFERRSAIMNDVLGD
VDLFELRALCERTCDELIDGFAGRGEADLITEYAQSMPMLLIGRMIGIPEAGLPELLASMNAATDGSGPE
AVAGHSRFVAIINALLADRRARPRPDLPSAMLGHPGKLTDEEASWDLLLIVGIGQQPITDWIGNTLRLML
TDSRFAVTLSGGRRSVGQALNEVLWEDTPLQNMSGRWAVRSTQLAGQHIQAGDMLVLSCAAANGDPQVRP
DSFEGPGGNHAHMSFGHGEHRCPYPAQEIAETIVRGAVEVLLDRLPDAVLAVSPDALVWRPSPWMRGLSA
LPVHFSPS

CYP157D2    Frankia sp. EAN1pec
            YP_001509751.1
            ABW14845.1
            52% to CYP157B1 Streptomyces coelicolor
MTTAREPARESLRGPAREPAREPARAARERPPGGRTPPCHLGEAQFQGGPARAYRDLRRKHGAVAPVLLD
GGLPAWLVLGYRELHYVLSHPEIFAHDPRHWAGWDDVPPDWAALPGVGHRPSVLRAEGAEHRRRYTAIQD
VLGAVDLFELRARAEEITDDVIDAFAGRGETDLIDSFAHRVPALVLASLCGPPEVDTAGLVHDLIVLIDD
GPDAAESHQRVLDRLRWLLADRREHPDDDIVSRLIAHPAGLADEEVVEDLAVVFGFGARAVAGWIGNSLR
LLLTDGSFALDLSGGRRSVMQALNQVLWEDTPMQVVAGRWATRNTQLGGQRIEAGDMIALGLGAGNADPQ
VRRGHAPDTQTGAGTSANSAHLSFGHGEHRCPYPAQEIAEVVTRTAVEALLDRLPNMWIAVPADALGWRR
TAWNRALTALPVRFSPV

CYP157E1    Frankia sp. EAN1pec
            YP_001509752.1
            ABW14846.1
            48% to CYP157A3 Thermobifida fusca
MTHPNPRQLGTCASGMPRAFGAVRQLGALRQYGASCPAPTTRRGGPEDTPSGEPVPGPSSGPPSGPRGGP
VRGTAGAHPPARPDLDARWPAHATAVRLPADGPGDDRAAFYRRIRDEHGPVAPVLLEGDVPAWLVLGYRE
VVYVAGTPALFGRDCRIWNAWDLVPPAWPLQSMVGQRPSLRALDGPAHARRLGAIGDVLGMFEPHGLRAR
AASGADALIDAMASDGRAELMTQYASPLPAMVAAGMWGLPDTDLTALARDLTLLVSGGTGARDARRRAHA
MLTRVVRRRRAQPGDDAVSALLTHPAGLRDDEVVEDVMATLIAGQAPTADWIGNTLRLMLTDPRFATDLA
GGRLSAGDAMAEVLWADPPIQNLVARWARRDVRLGGRWIRAGDLLIFGLSAANSDPWARPQPSGRPSGNH
AHLAFGHGEHRCPFPAQMTAETIATTAIEVLLDRLPDLELAVEPRDLRWRPSVWARGVAALPVRFTPP

CYP157F1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_871
           47% to CYP157C6 Frankia sp. CcI3
           missing about 33 aa at N-term

CYP157F2    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2868 81% to CYP157F1

CYP157G1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_4984
           50% to CYP157B3 Saccharopolyspora erythraea NRRL23338 

CYP157G2    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY6022 65% to CYP157G1

CYP157H1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY5124 51% to CYP157A1

CYP158A1      Streptomyces coelicolor cosmid 8F11 
              AL353864 CDS complement(25687..26910)
              40% to AF254925, 107E1, 107F1 34% to 107A1 probably a new family
              cloned and expressed by David Lamb and Steve Kelly

CYP158A2    Streptomyces coelicolor 2StG58 [Full Sequence] Sanger cosmid 
            AL939108.1 CDS 76346-77560 61% to 158A1
            Note this sequence shows greater than 40% identity to some CYP107 
            subfamilies
            cloned and expressed by David Lamb and Steve Kelly

CYP158A3   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV7130 58% to 158A1 from Streptomyces coelicolor

CYP158B1   Saccharopolyspora erythraea
           GenEMBL AY078067 4211..5416
           gene = rppB
           red pigment gene cluster
           47% to 158A3
MTDRCPARMYDPADLPGMTFDPVFLELLRDEPVARIRMRYGEGE
AWLLTRYEDVKFVTSDPRFSRKIMGRPFPKMTKHHIPMDRAISFSDPPEHARVRRVVA
RDFSPGSIERLRPTGREIMHRYLDELVASGPPADLVRHVTSPFPMAVLGELMGIPESD
RQWLIDCSSQVLSMAPDQAAVDRINGIKAEVAEYFLALVESRRADPRDDVVSTVAAAR
ERGDLDDEEVGAMTVLLALNGWHAVRNNSTNMVYVLLTDPELRSRLKADLALVPTAVE
ELLRYIPHKRGIGQPRIATEDVDIRGVRISKGDVVYVSYIAANWDEEVYPEPDRVDLD
RPEVPHLAFGHGPHYCMGPMLARMESQVLLSSLLTRLPDLALAVPPEQVAWQPNALIR
GPVELPVTW

CYP158B1    Saccharopolyspora erythraea NRRL23338
            SACE_1242, se: 1364163,1365368 (-) STRAND
            47% to CYP158A3
            gene = rppB
            red pigment gene cluster

CYP159A1      Streptomyces coelicolor cosmid F55 
              GenEMBL AL132991 CDS 6235..7458
              41% to 107K1 41% to 134 new family
              cloned and expressed by David Lamb and Steve Kelly

CYP159A2   Streptomyces hygroscopicus subsp. yingchengensis
           GenEMBL AY260760 983..2209
           84% to 159A1
           gene = shy1
MSAAHHLPDILSPEFAANPYPAYAVMREKEPLIWHEATQSYIIS
RYEDVERVFKDKKAEFTTDNYNWQLEPVHGKTILQLSGREHAVRRALVAPAFRGSDLE
QKFLPVIERNSRELIDAFRHTGSADIVNDYATRFPVNVIADMLGLDKADHARFHGWYT
AVIAFLGNLSGDPEVAAAGERTRVEFAEYMLPVIRERRANPGDDLLSTLCAAEVDGVR
MSDEDIKAFCSLLLAAGGETTDKAIAGILANLLSHPDQLAAVRADRSLIPAAFAETLR
YTPPVQMIMRQSATDVEVTGGTIPAGATVTCLIGAANRDERRYRDPDRFDIFRDDLAT
TSAFSAAAGHLAFALGRHFCVGALLAKAEVEVGLNQLLDAMPDLRLADGHDLVEQGVF
TRGPKTLPVRFTPVTA

CYP159A3   Frankia alni ACN14a
           YP_710491 
           CAJ58879
           52% to CYP159A1 Streptomyces coelicolor
           53% to CYP159A2 Streptomyces hygroscopicus subsp. Yingchengensis
MTTTPTTVPEKPDVLSAEFARDPHTYYKIMRDFYPVLHHEVSGYYFVSRY
EDVARIYKDSVGFSNENYAFQMEPVIGKTVIQMGGREHAINRQLITPALR
GNYLEELLPQVDELATEMIDKFRTAGRVDLAEDFTKWFPINVIVKMLDLP
REDLPKFHEWYSSLMAFLANLTNDPEIHAWGMRTQQEYPAYILPIIAERR
RNPGTDLISRLTQAEINDEQFSDEQIKALIGLLLIAGGETTDKSIASTLK
YLIMHPEQLEAVRQDPSLATRALVETLRYHPPVQIILRTTTDDVEVAGTV
IPVGSVVGCVNGAANRDERRFDDPDTYNIFRTDINIRQAFAGSADHIAFA
LGRHFCVGSLLAKREAETAINQILAAMPDIRFADGIEPTDAGLFTRGPES
LIVEFTPAS*

CYP159A4    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE2759 76% to CYP159A1

CYP159A5    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR4391
            84% to CYP159A1

CYP160A1      Streptomyces lavendulae LinA homolog.
              GenEMBL AF127374 CDS complement(43595.44782)
              gene="mmcN" 39% to D87924 new family

CYP161A1      Streptomyces noursei ATCC 11455 nyst.
              GenEMBL AF263912 CDS 57095.58279 gene="nysL"
              function="presumably involved in modification of the
              nystatin macrolactone ring" 36% to AF127374 = new family

CYP161A2   Streptomyces natalensis 
           GenEMBL AJ278573 81418..82611
           pimaricin biosynthetic gene cluster.
           58% to 161A1
           gene = pimD
MTAASHDLPCLNLEPPKMLKLSPLLRALQDRGPIHRVRTPAGDE
AWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLDLLISDADAESGRRQHAETR
RLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGDLHGELTVPFALTVLCEVIGV
PPQRRAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLNDGE
LTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPDVMARAVEEVLR
TARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAARTPN
PHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPVEQLRLKEGQLSGGFAELRVVW

CYP161A3   Streptomyces nodosus
           GenEMBL AF357202 56829..58019
           gene = amphL
           amphotericin biosynthetic gene cluster
           71% to 161A1
           note = probably hydroxylates amphotericin precursor at C-8
MVNPTPPPSLEDAAPSVLRLSPLLRELQMRAPVTKIRTPAGDEG
WLVTRHAELKQLLHDERLARAHADPANAPRYVKSPLMDLLIMDDVEAARAAHAELRTL
LTPQFSARRVLNMMPMVEGIAEQILNGFAAQEQPADLRGNFSLPYSLTVLCALIGIPL
QEQGQLLAVLGEMATLNDAESVARSQAKLFGLLTDLAGRKRAEPGDDVISRLCETVPE
DERIGPIAASLLFAGLDSVATHVDLGVVLFTQYPDQLKEALADEKLMRSGVEEILRAA
KAGGSGAALPRYATDDIEIADVTIRTGDLVLLDFTLVNFDEAVFDDADLFDIRRSPNE
HLTFGHGMWHCIGAPLARMMLKTAYTQLFTRLPGLKLASSVEELQVTSGQLNGGLTEL
PVTW

CYP161A4    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY1472 57% to CYP161A1

CYP161B1   Streptomyces sp. Tu6071
           ABB69759
           PlaO4 
  1 MAAQIQLPLD PPHPARPQHN LRALQKRAPV HRVSTAVGDP AWLVTGYQEI KQLLADPRLG
 61 RSHHDPENAA RSGASELLDG PRGDYDTEQK WIATMRSRLQ PFFSAGHVKA MRPRVEALVG
121 ELLDRLEKQG PPADLAEALA LLLPREVIGE LLGVPVEERE LLDEWTTAVS DARDRERSAA
181 GLAALHRYGH ELAARKRAHP TQDVVSWLCE DGTLSDDQVA QLAMGVLFAG YETTATALCV
241 GTALLLDSPE QWRALRENPG LAPTAAEESV RVVSRLLPPV IRYTREDLEI AGAEVRRGEL
301 VMLDIYAATH DESIFPDPDR FDITREDNPH LCFGFGLRYC IGAPLARLEL QAALTQLTTR
361 FPRMRLTVPV EDLTVRPGSF AAIPTSLPVI W

CYP161C1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_10607
           42% to CYP161B1 Streptomyces sp. Tu6071 ABB69759 
           40% to CYP161A2 Streptomyces natalensis 

CYP161C2   Streptomyces arenae TU469
           HQ292065
           David E. Cane
           Submitted to nomenclature committee Nov. 28, 2010
           Gene name PntM
           Catalyzes the oxidative rearrangement of pentalenolactone F
           To the antibiotic pentalenolactone
           89% to CYP161C1

CYP161C3   Streptomyces exfoliatus strain UC5319
           HQ292066
           David E. Cane
           Submitted to nomenclature committee Nov. 28, 2010
           Gene name PenM
           Catalyzes the oxidative rearrangement of pentalenolactone F
           To the antibiotic pentalenolactone
           84% to CYP161C1

CYP162A1   Streptomyces tendae nikkomycin 
           AJ250199 CDS 22..1212 gene="nikQ"
           38% to AF170880 new family

CYP162A2   Streptomyces ansochromogenes 
           AF322179.3
           nikkomycin biosynthesis gene cluster 
           gene SanQ 
           96% to 162A1

CYP162B1    Saccharopolyspora erythraea NRRL23338
            SACE_4920, se: 5495967,5497184 (-) STRAND
            41% to 162A1 NikQ in nikkomycin biosynthesis gene cluster
            41% to 162A2 AF322179.3 Streptomyces ansochromogenes 
            nikkomycin biosynthesis gene cluster SanQ (96% to 162A1)
VIQAPTVDLTDPELFSSNRFWEVLAWLRANDPVHWHPDAEGSGFWVVTRYDDVTAVYADA
ETFSSRFGMRLGSNDDAVSAVSQRMLIVSDPPDHTHLKRVLSKTFGGSEMSRLEGLVRDV
VREVVADAVEAGETDFLDVAKLIPNYVVCAVMDLPREDWAWVGRTTTDAFEGEDEETRSG
AHGEIFLYFDDLLRQRRGGSGEDFISRVARDRRATDVPDQDRLLTDEEIVFNCNGVLAGA
NETTRYSTAGGVLALAENPDQWRKLREGGAAAIPAAVEEILRWTVPGVHALRTATRPATI
RGQSIGVGDRVTIWNVSANRDEAVFADADSFVVDRSPNRHITFGAGRHLCLGARLARLEL
SAFLSELLDRVEEIELCGEPQYNASNFTWGLRELPVRLVRKQKVP 

CYP162C1    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR582
            42% to CYP162A1

CYP163A1   Streptomyces spheroides novobiocin 
           AF170880 CDS 9688..10911 gene="novI"
           38% to AJ250199 new family

CYP163A2   Streptomyces roseochromogenes subsp. oscitans
           AF329398 15196..16419
           Clorobiocin biosynthetic gene cluster
           90% to 163A1
           gene = cloI
MSTRPTVSPDELEQIDLASPILHAEYELGEVFRYLRANRPMYWQ
QPRGEQPGFWVISRYADVNEVYKDKAHFTTEHGNALATLLTGGDSASGAMLAVTDGVR
HHQVRNLLSKGFSPQMLDLIANSLRETVDGLLLAALDRGECDAAQDIAANVPLGAICD
LLEIPQTDRKYLLGLTAHAWSTDYADETPEEGWVAKNEILLYFSKLLKERRGGDRDDM
VSLLANCRIDGHPLNAAEQVANCYGLMIGGDETGRHAITGTILALIENPDQWRALKNG
DVDLKTATEEALRWTVPSLHGGRKATGDVVINGQQIKAGDVVSVWISSANRDEAIFDA
ADEFKLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYS
SILHGMSSLPIRITV

CYP163A3   Streptomyces antibioticus
           GenEMBL AF322256 22228..23478
           simocyclinone biosynthetic gene cluster
           62% to 163A1
           gene = simI
MNPRPMLSPDVLEDIDLNDRQLHADYDLSEVWRYLRAERPFYYQ
TARGSQPGFWVVTRHADCTAVYKDKTNFTAERGNVLPTLLAGGDSASRTMLALTDGDR
HTQVRNLLMKAFSPKMLSNIGQSLRTTVDGLLRDAIEKGECDFARDVSGKVPLVAICD
LLAVPQEDREYLLSLTAHALSADEADATAEDNWTAKNEILLYFADLAESRRSSGHNDV
VSLLATSSIEGEPLSDGELMANCYGLMIGGDETGRHAITGGLRALIHHPDQWRMLRNG
EADLQTATEEVLRWTVPSLHGARTATADVVVNGKQQIRAGEIVSVWFASANRDEEVFR
DADRFDLNRTPNKHLTFAFGPHFCLGHYLARMEVEAILDGLRRMVDDIQQTGPEKLIY
SSILQGISSFPALLKPDRRVPPQT

CYP163A3   Streptomyces antibioticus
           GenEMBL AF324838 26497..27762 
           simocyclinone biosynthetic gene cluster
           gene = simD1
           note="involved in aminocoumarin formation"
           same seq as AF322256 except this seq has MKGTM added
           at the N-terminal (a disagreement on start codon)

CYP163B1    Salinispora tropica (marine actinomycete)
            Strop_1021 	complement(1150011..1151288)
            46% to CYP163A3 Streptomyces antibioticus
MTAADTGRVGSGESQTPAHTVDLADPATFANHDLTGFWQQLRDEEPIHWNPPTAGRRGFW
VVSRYADILDVYRDDVTFTSERGNVLVTLLAGGDAGAGRMLAVTDGPRHAELRKLLLRAL
GPRVLAPVCAAVRTNTRQMIREAVTKGECDFASDIASRIPMMTISNLLGVPDADRAFLLS
LTKTALSADDESISETESAMARNEILLYFQDLMEFRRDHPGEDVVSMLVNSSIDGAPLSD
DDIVLNCYSLIIGGDETSRLTMIDSVNTLAAHPQQWRRLKDGQCEIDKAVDEVLRWASPS
MHFGRVAARDTILHGVRIRADDIVTLWHASGNRDERVFHRPEVFDLGRTPNRHLSFGHGP
HYCIGSYLAKVEISELLIALRDLTSGFETTGEPQRIRSNLLTGFATMPVRFVPDRAGLAR
DALDG

CYP163B2    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR3267
            56% to CYP163B1

CYP163B3      Streptomyces sp. Acta 2897 
              EMBL AEA30275.1
              UniProt tr|F2YRY7|F2YRY7_9ACTO P450 monooxygenase
              sky32 for making skyllamycin
              62% to CYP163B2 SGR3267 Streptomyces griseus
              56% to CYP163B1 Salinispora tropica (marine actinomycete)
              51% to CYP163C1 SBI_8210 Streptomyces bingchengensis
              48% to CYP163A1 Streptomyces spheroides novobiocin
              49% to CYP163A2 Streptomyces roseochromogenes subsp. oscitans
              49% to CYP163A3 Streptomyces antibioticus
MTAHTLPIPDDISTINLTDPRTYEVNDLSEYWRQLRTTRPLYWHPPVGDAPGFWVVSRYA
DVMALYKDNKKLTSEKGNVLVTLLAGGDSAAGKMLAVTDGAMHRGLRNVLLKSFSPQALK
PIVDQIRVNTTRLVVDAARRGECDFAADVAEQIPLNTISDLLGVPAADREFLLKLNKSAL
SSEDADQSATDAWLARNEILLYFSELVAERRAKPTEDVISVLANSMVDGKPLTEEVIVLN
CYSLILGGDETSRLSMIDSVQTFTQYPDQWELLRDGKVTLESATEEVLRWATPAMHFGRR
AVTDMELHGQVIAAGDVVTLWNNSANRDEEVFADPYAFDLNRSPNKHITFGYGPHFCLGA
YLGRAEVHALLDALRTYTTGFEITGEPQRIHSNFLTGLSRLPVRIQPNEAAIAAYDSDNG
VRS

CYP163C1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_8210
           49% to CYP163A3 Streptomyces antibioticus 

CYP164A1      Mycobacterium leprae cosmid B1788 
              GenEMBL AL007924 CDS complement(38296-39228)
              40% to AL049754 partial 

CYP164A1      Mycobacterium leprae 
              GenPept CAC31043                
              NC_002677 complement(2481544..2482848)
              locus_tag = ML2088
              100% match but this is complete
  1 MRTCVPTRTC VYAFIEYLSH NRPMGTNPPS LVEAQMLLLR LIDPGTRADP FPVYRALIDY
 61 GPMQLPGMPL TVFSSFSDCD EALRHPLSAS DRLKATLAQQ AIAAGAEPRP FYASSFMFLD
121 PPDHTRLRKL VSKAFAPKVV QALEGDIAAL VDSLLDKGAA AGQFDVIADL AFPLAVAVIC
181 RLLGVPYEDA PEFGRVSALL VQSVDPFITI TGEPPEATEE RLRAGVWLRD YLEQLVKCRR
241 GTPGEDLISR LIELDESGDQ LTEEEIIATC GLLLVAGHET TVNLIANAVL AMLRNPSQWK
301 ALSSNPQRAP LVVEETLRYD PAIHLIGRVA AKDMTIGQTT LTEGDTMVLL LAAANRDPAV
361 YSRPDEFDPD RPSSRHLAFA VGSHFCLGAA LARLEATVTL SAISARFPQV QLAGELVYKP
421 NVAMRGMSAL PVQV

CYP164A2   Mycobacterium smegmatis 
           MSMEG6272 TIGR 
           61% to CYP164A1 
           67% to CYP164A4 Mycobacterium vanbaalenii
           66% to 164A3
MHNGWMSTAATAQEAQGLLLQLLDPATRADPYPIYDRIRRGGPLALPEAN
LAVFSSFSDCDDVLRHPSSCSDRTKSTIFQRQLAAETQPRPQGPASFLFL
DPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDGPEFNLIDNL
AYPLPVAVICRLLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDE
QMKAGMWLRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATC
NLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRASAVIEETMRYD
PPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD
RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR
NLTLRGMSTLSIAV

CYP164A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM5268
           57% to 164A1

CYP164A3P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 164A3 M. marinum in conserved region

CYP164A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01206517.1, EAS24279.1 
           60% to 164A1
MRLLHLHALHPRVSAPLVQGQGDAVRDAVHDPQRAVRHPPRRRHPRRHPRGPVRRAARARPRPVLRQGVA SAGVFDLHPFRLVHNKSMTTAAEPQSLLLQMLAPEVRADPYPVYAQILAHGPMQLPGNNLTVFSSYADCD EVLRHPDASSDRLKSTAAQRAIADGAEARPFGPPGFLFLDPPDHTRLRWLVSKAFVPKVVKALEPDIVTM VDGLLREAEAGATFEAIGGLAYPLPVAVICRLLGVPLEDEPQFSAASALLAQSLDPFISVTGSAGSGFEE RMQAARWLRGYLRELIARRRRDPGEDLMSGLIHVEESGDQLTEDEIVATCNLLLVAGHETTVNLIANAIL ALLRNDGQWAALAADPGRAAAVIEETLRHDPPVQLVGRIAGQDMTIGGERSDGGNVAGGVTVPKGDNILL LTAAAHRDPDHVDRPDEFDPDRPVIRHLGFGKGAHFCLGAPLARLEATLALTALTSRFPDAKLAAEPVYK PNVTLRGMSELSITLA

CYP164A5P     Mycobacterium leprae cosmid B1450
              GenEMBL AL035159.1 
              45% to 164A1 C-term region before heme binding seq
AVDALLCFLSPPGLAGPRFAVTDVEIGQHTVVAGQTVRLYLASANHDPQRFNCTDELEPTRPAPHTA

CYP164B1   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           45% to 164A1 missing about 112 aa at N-term
           clone name SP0831

CYP165A1    Amycolatopsis mediterranei 
            Y16952 CDS 224..1399 gene="oxyA"
            85% to AJ223999 CDS 31325..32500 42% to Y16952 CDS 1449..2645 
            41% to AJ223999 32520..33740

CYP165A2    Amycolatopsis orientalis cosmid PCZA363.
            GenEMBL AJ223999 region 31325-32500
            van Wageningen,A., Kirkpatrick,P., Williams,D., Harris,B.,
            Kershaw,J., Lennard,N., Jones,M., Jones,S. and Solenberg,P.
            Sequencing and analysis of genes involved in the   
            biosynthesis of a vancomycin group antibiotic
            Unpublished

CYP165A3    Amycolatopsis orientalis
            GenEMBL AF486630
            Zerbe,K., Pylypenko,O., Vitali,F., Zhang,W., Rouset,S., Heck,M.,
            Vrijbloed,J.W., Bischoff,D., Bister,B., Sussmuth,R.D., Pelzer,S.,
            Wohlleben,W., Robinson,J.A. and Schlichting,I.
            Crystal Structure of OxyB, a Cytochrome P450 Implicated in an
            Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
            J. Biol. Chem. 277 (49), 47476-47485 (2002)
            oxyA 
            84% to CYP165A2
MFEEKNALRGTEIHRRERFDPGPELRALMAEGRMSVMESEESPG
GRTGWLATGYEETRQVLGSDKFSAKLLFGGTAAGRIWPGFLNQYDPPEHTRLRRMVAS
AFTVRRMRDFRPRIEAVVKATLDDIEATGGPVDFVPRFAWPIATTVICDFLGIPRDDQ
AELSRVLHASRSERSGKRRVAAGNKYWTYMGQVAAKTRRDPGDDMFGAVVREHGDDIT
DAELLGVAAFVMGASGDQVARFLSAGAWLMVEHPEQFAVLRDDPDSVPDWLNEVARYL
TSDEKTTPRIALEDVRIGDQLVKKGDAVTCSLLASNRHRFPDPEDRFDITREKPSHVT
FGHGIHHCLGRPLAEMVFRTAIPALAHRFPTLRLAEPDREIKLGPPPFDVEALLLDW

CYP165A4   Streptomcyes toyocaensis strain NRRL 15009 
           GenEMBL U82965 AF039028 complement(11438..12613)
           72% to CYP165A1
MFEEINVVRASQLHRRDRFDPVPELHSLMKEGGLTVLGTEDSTE
GRTAWLATGIDEVRQVLGSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVP
AFSHRRMQKFRPRVEQIVQDSLDTIESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQ
ADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAIT
DAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVPEWLDETMRYL
TTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPNYPSAEDEFDITREKAEHLA
FGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPPFDVEALLLDW

CYP165A5   Actinomadura sp. ATCC 39727 
           GenEMBL AJ561198 complement(23387..24568)
           gene = dbv14
           gene cluster for biosynthesis of
           glycopeptide antibiotic A40926
           function="cross-linking of amino acids 2 and 4"
           72% to 165A1
MEVFEELNVVLPGELHWRDRFDPVPQLRSFMAEGPMTELGAEEG
PGGRTAWLATGFDEVRQVLGSDKFSSRLLYGGTAAGIVFPGFITQYDPPEHTRLRRVV
SPAFTVRRMERFRPQVDQVVEDCLDAIESIGGPLDFVPHFGWSIATTATCDFLGIPRD
DQAELSRSLHASRSQRAASRRGAAGNKFMTYMGQVVARTRRDPGDDMLSVVVREHGDE
ITDAELTGLAAFVMGAGGDQVARFLAAGAWLMAEVPEQFALLRDKPDVVPDWLEEMVR
YLTIDEKLTPRIALEDVRIGDRIVKAGDTVTCSLLGANRRHFPGPDDQFDLTRDRAPN
VAFGHGIHHCLGRPLAELIFRSAIPALARRFPALRLAEPEQEIRLGPPPFDVKALLLDW

CYP165A6   Actinoplanes teichomyceticus 
           Genpept CAG105017 
           GenEMBL AJ632270 CDS 47098..48273
           teicoplanin gene cluster
           80% to CYP165A4 Streptomcyes toyocaensis strain NRRL 15009
MFEEINVVRAAELHRRDRFDPVPQLRSLMAEGPLTTLGTEESPG
GRTAWLATGYDEIRQVLSSDDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVAP
AFAVRRMQKFQPQVERVVQDSLDAIEALGGPVDFVPRFGWSVATTATCDFLGIPRDDQ
ADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVREYGDEIT
DAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTVPDWLDEVIRYL
TTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANRRNFPRPEDRFDITRVRPEHLA
FGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGPPPFDVEALLLDW

CYP165B1    Amycolatopsis mediterranei 9.9kB DNA 
            Y16952 CDS 1449..2645 gene="oxyB"
            87% to AJ223999 32520..33740 47% to Y16952 CDS 2795..4015 
            47% to AJ223998 gene 1 53% to U84350 partial 

CYP165B2    Amycolatopsis orientalis cosmid PCZA363.
            GenEMBL AJ223999 region 32520-33740
            van Wageningen,A., Kirkpatrick,P., Williams,D., Harris,B.,
            Kershaw,J., Lennard,N., Jones,M., Jones,S. and Solenberg,P.
            Sequencing and analysis of genes involved in the   
            biosynthesis of a vancomycin group antibiotic
            Unpublished

CYP165B3    Amycolatopsis orientalis
            GenEMBL AF486630; AAL90878.1
            Zerbe,K., Pylypenko,O., Vitali,F., Zhang,W., Rouset,S., Heck,M.,
            Vrijbloed,J.W., Bischoff,D., Bister,B., Sussmuth,R.D., Pelzer,S.,
            Wohlleben,W., Robinson,J.A. and Schlichting,I.
            Crystal Structure of OxyB, a Cytochrome P450 Implicated in an
            Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
            J. Biol. Chem. 277 (49), 47476-47485 (2002)
            Zhang W., Zerbe K., Vrijbloed J.W., Robinson J.A.
            DNA sequence coding for P450 monooxygenases of vancomycin producer
            87% to CYP165B1 and 85% to CYP165B2
MSEDDPRPLHIRRQGLDPADELLAAGALTRVTIGSGADAETHWM
ATAHAVVRQVMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRK
LTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPR
DDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYG
DDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQRAVDEL
IRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREP
IPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLT
ELMVAW

CYP165B4   Streptomcyes toyocaensis strain NRRL 15009 
           GenEMBL U82965 AF039028 complement(9077..10273)
           77% to CYP165B1
MSGDDRPPIHTLRQGFDPADELRAAGELTRVRLGSGADAEHTWL
ATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELVGNLMDYDPPEHTRLRRL
LAPGFTHRKIRRMAPYIEQIVTERLDEMEREGSPADLIELFADEVPGPVLCELLGVPR
DDRAMFLQLCHRHLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHG
DTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPAAERAVDEL
IRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREA
VPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATEFRLSTPAYGIS
RLMVTW

CYP165B5   Streptomyces lavendulae
           GenEMBL AF386507 42222..43493
           complestatin biosynthetic gene cluster
           58% to 165B1
           note = ORF11; comO2
MPQQAQRQAPQQQPRAQQAYPELLYTRRTRFDPADDLRAAPPLS
RYVIGPNESDEWVWLATGYTEVRRILGDHTNFSTRRRWGAEGPNWRPPELVGHLMDYD
PPEHTRLRQMLTPEFTVRRLRRLEPDITAIIEEHLDTVEATGPGADLMPLFAQPVPGE
VLCELIGVPRDDRPEFLRHCHRHLDFSRSRKVRAADGAAFSRYLVSMVARQRKDPDDG
FIGALVREHGDDFTDEEMRGVCVLLILAGIDNIEGMIGLGVLAMLENPDQLPLLLGER
DSTGGPGAGKGDGGRLASDRALDELIRYMSVANAPTPRTAVNDVRIGDQLIKAGETVI
CSLTMANRDPALTDGPDRLDLAREPVAHVAFGHGVHHCLGAALARTELRIAYKALWRR
FPELRLAVPVEEVRFYNRALAHGVHRLPVAW

CYP165B6   Actinomadura sp. ATCC 39727 
           GenEMBL AJ561198 complement(21025..22221)
           gene = dbv12
           gene cluster for biosynthesis of
           glycopeptide antibiotic A40926
           function="cross-linking of amino acids 4 and 6"
           84% to 165B2
MSGDGARPLHTRRQDLDPADELRAAGTLTRITIGSGADAETTWL
ATGYTVVRQVLGDHRRFSTRRRWNERDEIGGRGNFRPRELVGNLMDYDPPEHTRLRQK
LTPGFTLRRIRRLKPYIEQIVTERLDALERAGPPADLVELVADEVPGAVLCELIGVPR
DDRAMFMQLCHGHLDASRSQKRRAAAGAAFSRYLLAMIARERKDPGEGLLGAVLAEYG
DTATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIAALQGDDQSADRAVDEL
IRYLTVPYAPTPRVAMEDVTIGGQVIKEGETVSCSLPMANRDPALLPDAGRLDVRREP
VPHVAFGHGVHHCLGAALARLELRTVYTALWRRFPTLRLADPDREPSFRLTTPAYGLT
SLMVAW

CYP165B7   Actinoplanes teichomyceticus 
           Genpept CAG105019 
           GenEMBL AJ632270 CDS 49590..50636
           teicoplanin gene cluster
           82% to CYP165B4 Streptomcyes toyocaensis strain NRRL 15009
MRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPP
EHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGPPADLIELFADEVPGAVL
CELIGVPRDDQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFI
GSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS
ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDAD
RLDVTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRT
STPAYGLTSLLVAW

CYP165C1    Amycolatopsis mediterranei 9.9kB DNA 
            Y16952 CDS 2795..4015 gene="oxyC"
            90% to AJ223998 gene 1 89% to U84350 partial 
            47% to AJ223999 32520..33740
            47% to Y16952 CDS 1449..2645 40% to AJ223999 CDS 31325..32500

CYP165C2    Amycolatopsis orientalis hypothetical 
            U84350 CDS  <1..935
            92% to AJ223998 gene 1 new family

CYP165C3    Amycolatopsis orientalis cosmid PCZA363.
            GenEMBL AJ223999 region 33791-34244 incomplete
            This gene continues on AJ223998
            van Wageningen,A., Kirkpatrick,P., Williams,D., Harris,B.,
            Kershaw,J., Lennard,N., Jones,M., Jones,S. and Solenberg,P.
            Sequencing and analysis of genes involved in the 
            biosynthesis of a vancomycin group antibiotic
            Unpublished

CYP165C4    Amycolatopsis orientalis 
            GenEMBL AF486630
            Zerbe,K., Pylypenko,O., Vitali,F., Zhang,W., Rouset,S., Heck,M.,
            Vrijbloed,J.W., Bischoff,D., Bister,B., Sussmuth,R.D., Pelzer,S.,
            Wohlleben,W., Robinson,J.A. and Schlichting,I.
            Crystal Structure of OxyB, a Cytochrome P450 Implicated in an
            Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis
            J. Biol. Chem. 277 (49), 47476-47485 (2002)
            OxyC
            93% to CYP165C2 83% to CYP165C3
MGHDIDQVAPLLREPANFQLRTNCDPHEDNFGLRAHGPLVRIVG
ESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDP
PEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHA
LCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGL
LGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPE
KAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDP
DVLDANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYR
SAFVDCPDQVPVTW

CYP165C5   Streptomcyes toyocaensis strain NRRL 15009 
           GenEMBL U82965 AF039028
           complement(6312..7490)
           70% to CYP165C3
MRRTLCDPHEDMFALRAHGPLIRIEGNASDQMSTDYVWQAMGYD
VVRKILGDHENFTTRLRLTDAQPLSGEGVSVPPELAGQISIYDPPEHTRLRRMLTPEF
TVRRIRRLEPAIEGIIEEHLDALEGAGPPADLQVLFADPVGGETLCELLGVPRDDRNE
FIRRVRQNVDLSRGYKARAADSAAFNRYLMTLITRQRKDPDEGFLGMLVREHGDRITD
EELKGVCTALILGGVESVAGMIGFGVLALLEHPDQRRLLFGSREEADRLVNELLRFLS
AVQQPTPRMAVRDVVVEGQLIKAGEYVLCSILMANRDEGLTSDSHLLDANREPLPHVA
FGHGIHHCIGAAVARAVLRITYQSLWRRFPRLSLAVPAGEVKFRNAFIDSPDRLPVTW

CYP165C6    Actinomadura sp. ATCC 39727 
            GenEMBL AJ561198 complement(19681..20943)
            gene = dbv11
            gene cluster for biosynthesis of
            glycopeptide antibiotic A40926
            function="cross-linking of amino acids 5 and 7"
            76% to 165C5
MRIDSEWSFDPGMDDDIDAGAPVLQPTANYMMRTHCDPHEDMFA
LRAHGPLVRIGGDAATQLRVDYVWQALGYDVVRRILGDHENFTTRPRWSSAPSIAGEP
IPPNLVGQLSVYDPPEHTRLRGMLTPEFTARRIRRLEPAMQDLIDDRIDELEAAGPPA
DVQALFADPVGGGVLCELLGIPRDDRIEFIRRVRQNVDLSRGFKARAADSAAFNRYLN
GLIIRQRKDPDEGFIGMLVREHGDDVTDEELKGVLTALILGGVETVAGSIGFGVLALL
DHPDQRQSLFAGREEADRVVGELLRFLSPVQQPNPRLAVRDVVVDGQLIKAGDYVLCS
ILMANRDEALTPNANVLDVRRDCGSHVGFGHGIHYCIGAAIARTLLRMAYQSLWRRFP
GLRLAVSAEEVKFRNAFIDCPDELPVTW

CYP165C7   Actinoplanes teichomyceticus 
           Genpept CAG105021 
           GenEMBL AJ632270 CDS 52502..53746
           teicoplanin gene cluster
           78% to CYP165C6 Actinomadura sp. ATCC 39727
MFTGMDHDIDEVAPVVEPTANYMRRTVCDPHEDMFALRAHGPLI
RIGGDAAVQMGADYLWQAMGYDVVRQILGDHENFTTRLRLTASEPISGEGATKPQELV
GQISTYDPPEHTRLRRMLTPEFTVRRVRRLEPAIQELIDDRIDAMEAAGPPVDVQTVF
ADPVGGGALCELLGIPRDDRNQFMRRVRQNVDLSRGYKARAADSAAFNRYLQSLITRQ
RKDPDEGFLGMLVRDHGDDITDEELKGVCTALLLGGVETVAGMLGFGVLALLDHPDQR
RLLFAGREEADRLVNELLRYLSAVQQPTPRMAVKDVVVDGQQIRAGEYVLCSILMANR
DEALTPHPNVLDAEREPAPHIGFGHGIHHCIGAAVARTVLRMAYQTLWRRLPGLRLAI
PAGQVKLRNAFIDSPDQLPVTW

CYP165D1   Streptomcyes toyocaensis strain NRRL 15009 
           GenEMBL U82965 AF039028 complement(10263..11417)
           45% to CYP165A3
MALPLPHRRHRLDPVPEFHDLQNEGPLHEYDTEPGMDGRKQWLV
TGYHEVRDILADPERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDLEDVGSPVDFVRYAAWPIPALIACEFLDVPRDDRAELSRM
IRESRESRLPRQRTSSGMGVVNYTQKLAARKRLDPGEGMIGVIVREHGAEVSDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREHPELVDGATEELLRHASIVEAP
APRVALEDVSVAGRDIRAGDVLTCSMMAVNRPQGEHFDITRENPKHMAFGYGIHHCLG
APLARLQLRVALPAVLRRFPSLRLAVPEEDLRFKPGRPAPFAVEELPVEW

CYP165D2   Actinomadura sp. ATCC 39727 
           GenEMBL AJ561198 complement(22211..23365)
           Gene = dbv13
           gene cluster for biosynthesis of
           glycopeptide antibiotic A40926
           function="cross-linking of amino acids 1 and 3"
           75% to 165D1
MVVPLPHQRLRLDPVPALFDLQEDGPLHEYDTEPGLDGHKQWLV
TGYGEIREILADANRFSSMRPVEDEAERAWLPGILQSYDAPDHTRLRRTVTRANTARR
IESLRPVVEETVEDCLADLESMGSPVDFVRNAAWPIPALIACDFLGVPRDDQAELSRM
FRDSRESRVPRQRNVSGLGIVDYARKLAARERLDPGTGMIGGIVREHGGEVTDEELAG
LVEGIMIGAVEQMASQLAIAVLLLVTHPDQMALLRERPELADSAAEEVFRYASIVETP
SPRTALVDTRLAGRDIHAGDVLTCSILAGNRAREDRFDLTRGNPEHLAFGHGVHFCLG
APLARLQAQVALPALVRRFPSLRLAVPAEDLRFKPGKPAPFAVEELPVEW

CYP165D3   Actinoplanes teichomyceticus 
           Genpept CAG105018 
           GenEMBL AJ632270 CDS 48296..49450
           teicoplanin gene cluster
           86% to CYP165D1, 75% to CYP165D2
MALPLPHQRLRLDPVPEFEELQKAGPLHEYDTEPGMDGRKQWLV
TGHDEVRAILADHERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDFESVGAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELSRM
IRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELIDSATEEVLRHASIVEAP
APRVALADVRMAGRDIHAGDVLTCSMLATNRAPGDRFDITREKATHMAFGHGIHHCIG
APLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPGRPAPFAVEELPLEW

CYP165E1   Streptomyces lavendulae
           GenEMBL AF386507 41015..42208
           complestatin biosynthetic gene cluster
           45% to 165B1
           note = ORF10; comO1
MASRDVPVYNRRDRLDPVPELVELRNRCPVLRTELHGGPSSQVV
GWLVTGIDESREVLSDQHRFTMLPPADTEAQSRRLQNIGNPLHYDPPEHTRLRKMLNP
EFTMRRLRRLQPRIDAVVEECLDAMEQAGAPADLMQHFAWQIPGHTACELLGVPRDDR
AELSRHLDITRDDGRGRARQMAAGRAYRAYFHQLTARQRRDPGDDLLGMLVREYGDEI
TDEELEGLAASLTSAGIENVASMLGLGTLVLLEHPDQLAELREKPELIDRAVEELLRH
VSVIPTLSPRTALEDVPLGGHVVPKGERVICSAFAANRIATPGDDLEDGFDITREPAP
HMAFGHGVHHCLGAPLARMQLRTAYQALWRRFPELRLAVPHEEIRFRMPSSRVYSVDA
LPVAW

CYP166A1       Amycolatopsis mediterranei rifamycin.
               AF040570 CDS 2652..3842 identical to AJ223012
               similar to Streptomyces Sp. ChoP" 
               probably a new family 41% to 105C1 but less to other 105s

CYP166B1   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           46% to 166A1
           clone name SP0879

CYP167A1     Sorangium cellulosum = Polyangium cellulosum
             AF210843 CDS 62369..63628 gene = epoF
             35% to 107B1 new family

CYP167A1     Sorangium cellulosum = Polyangium cellulosum
             GenEMBL AF217189 56757..58016 
             epothilone gene cluster
             gene = epoK
             note = P450 epoxidase

CYP168A1     Pseudomonas aeruginosa
             NC_002516 complement(2792798..2794132)
             locus_tag = PA2475
             35% to 107P1
MDDAFSEEGSAQPRHDAQRPALAPRSDGFDIHTYHPDFVADPYP
LLRLIRSRAPVCRDQASIWWISRYADVSACLRDRRFSADPARLGAAGVRQGGASWFGH
QQLQPLARFYDNFMLFNDAPRHTRLRRLFAPAFGPDAVRRWEARIEVLVEELLDSLLE
RREPDLLRDFAEPLTIRVAAELFGFPREDTGQLLPWGRDLAAGLDLAASHGDAGQINR
SAVAFSDYLQRQARGWSDGSSRPPSGAAPSILDGAAMLEAGLGLEDLVAAYAMVFMAA
FETTISMVGNATLALLTHPDQLDLLRRCPELAANAVEELLRFDGAVRGGVRCTLEEVE
IGGQRIPPGEKVWLSFLAANRDPEMFAAPDRLQLQRANAKQHVAFAHGPHYCLGAYLA
RLELQCALRGLVRRRFALASEPTDLRWRRSSVFRTLERLPIVPEGDAQKTCE

CYP169A1   Pseudomonas aeruginosa
           NC_002516 complement(4121113..4122390)
           locus_tag = PA3679
MQQTIDCPIRRRLAHLPWANDGRAGVRHWLEMQRDPLAWLQKMH
VAQPDLAVARMGPQRLWCLFHPQAVQELMVDRRDDLQRWQPALCMLKQWNGRSFMMRE
GAPAQARRKEVRPHLAPPPASEVRRLAAEWGERVEEGREYDLDLEMAAFSVTLSGHAL
FDVDLQPSAYRIAKAVRLLSRVALLEMSTGLPLGHWFPSKLCPRKRWALGQLREAVGE
VAERSPRPLADLRDELCTLLMASHQSTGVTLTWSLLLLAQRPELLARLRAELAGVNWT
AIRSVADLRDCALLRAVLQECLRLYPPAYGLAPRQVTADIEVFGQRLKRGDVTMVSSW
ITQRDPRWFEAPLEFRPERFLEPARWPRGAYFPFGLGDRACPGTAMAMIDLAAALAYW
VEHWDIMHDGDLAPRGWFSLRPQRARVRFRRRA

CYP170A1  Streptomyces coelicolor cosmid 7E4 gene="SC7E4.20
          GenEMBL AL359214 CDS 18278..19663
          32% to Streptomyces avermitilis CYP171A1
          cloned and expressed by David Lamb and Steve Kelly

CYP170A2  Streptomyces avermitilis
          No accession number
          Submitted by David Lamb and Haruo Ikeda 9/3/02
          Clone name SAV3031 79% to CYP170A1 from Streptomyces coelicolor

CYP170A3  Streptomyces lividans
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          99% to CYP170A1 Streptomyces coelicolor (ortholog)

CYP170A4  Streptomyces viridochromogenes
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          85% to CYP170A1 Streptomyces coelicolor

CYP170A5  Streptomyces ghanaensis
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          81% to CYP170A1 Streptomyces coelicolor

CYP170A6  Streptomyces sviceus 
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          80% to CYP170A1 Streptomyces coelicolor

CYP170A7  Streptomyces griseoflavus
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          80% to CYP170A8 Streptomyces sp E14
          75% to CYP170A1 Streptomyces coelicolor

CYP170A8  Streptomyces sp E14
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          80% to CYP170A7 Streptomyces griseoflavus
          73% to CYP170A1 Streptomyces coelicolor

CYP170B1  Streptomyces albus 
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          63% to CYP170B3 Streptomyces SPB78
          62% to CYP170B2 Streptomyces SPB74
          55% to CYP170A1 Streptomyces coelicolor

CYP170B2  Streptomyces SPB74
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          92% to CYP170B3 Streptomyces SPB78
          51% to CYP170A1 Streptomyces coelicolor

CYP170B3  Streptomyces SPB78
          No accession number
          David Lamb
          Submitted to nomenclature committee 9/29/2011
          92% to CYP170B2 Streptomyces SPB74
          52% to CYP170A1 Streptomyces coelicolor

CYP171A1 Streptomyces avermitilis polyketide synthase gene cluster 
         GenEMBL AB032367 CDS complement(31914..33284)
         gene="aveE"
         note="probably catalyzes furan ring formation at C6 to C8
         32% to CYP170A1

CYP171A1   Streptomyces avermitilis
           GenEMBL AB032367 CDS complement(31914..33284)
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV941_aveE see above entry

CYP171A2    Streptomyces nanchangensis
            GenEMBL AY129009 
            complement(2614..3993)
            MeiE; involved in meilingmycin biosynthesis
            62% to 171A1
MPAPLQVPDVPGSWPVVGHLPQLARRPLDFLSSLADHGDLVRIR
LGRKPVYVATHPDLVRSLLVTDAHAYTRGAGHAKALAFIGPILVATTGEPHRRQRRMM
QPCFHRQRLGSYVSAMCSAATETADSWSAQDVVDVVPVMTELATAMIAKSLFVSERAA
HAEAELRKTGNAILTVARMSAILPGIYRRLPTPGNRQLPPARTVIEETIAAYRAEGQD
HGDMLSTLLRTTDATGTGLTDEEIRDEVMGLAITGIGGPAAIASWIFYELGQNPDLER
RLHEELDTVLDGRPPSSQDLTRLVFTQRLVKEALRKYPGWVGARRTRESVRLGGHEIP
ADAEVMYSAYALQNDPRWYPDPERFDPDRWDPQQNATRVKKGAWVPFSGGVYKCIGDA
FTETETAVAVAVIASRWRLRPADGRSVRASHLATHVVPRPLRMVVEPRSRNKDEAERS
PHEAPQVSR

CYP171A2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_9777
           99% to CYP171A2 Streptomyces nanchangensis 
           only 2 aa diffs, missing 15 aa at N-term

CYP172A1   Campylobacter jejuni 
           GenEMBL AL139078 comp(120285-121649)
           Parkhill,J., Wren,B.W., Mungall,K., Ketley,J.M., Churcher,C.,
           Basham,D., Chillingworth,T., Davies,R.M., Feltwell,T., Holroyd,S.,
           Jagels,K., Karlyshev,A., Moule,S., Pallen,M.J., Penn,C.W.,
           Quail,M., Rajandream,M.A., Rutherford,K.M., VanVliet,A.,
           Whitehead,S. and Barrell,B.G.
           The genome sequence of the food-borne pathogen Campylobacter jejuni
           reveals hypervariable sequences
           Nature 403 (6770), 665-668 (2000)
           only 28% to 102A3 

CYP172A1   Campylobacter jejuni subsp. jejuni NCTC 11168
           GenPept CAB73835                 
           100% match
  1 MSECPFFPKP YKNKASTLLT FLLKRRSWLD GLYERSYKMQ TGYVKMPNFD LYVINDTKEV
 61 KRMMVDEVRE FPKSAFLHEL LSPLLGESIF TTNGEVWKKQ RELLRPSFEM TRINKVFNLM
121 SEAVADMMDR FSKYPNHAVI EVDEAMTFIT ADVIFRTIMS SKLDEEKGKK ILNAFVTFQE
181 QSVHTAMRRM FRFPKWLSYV LGDCKRAKAG DVIRQVLSDI IKPRYDMADN AEFEDILGSL
241 LLVVDADTNK RFSFEEILDQ VAMLFLAGHE TTASSLTWTL YLLSLYPKEQ EKAYEEITQV
301 LQGGVIEISH LRQFKYLTNI FKESLRLYPP VGFFAREAKK DTQVRDKLIK KGSGVVIAPW
361 LIHRHEEFWT NPHGFNPSRF EGEYKKDAYL PFGVGERICI GQGFAMQEAI LILANILKTY
421 KLELEEGFVP DVVGRLTVRS ANGMRIKFSK RKL

CYP173A1   Mesorhizobium loti 
           GenEMBL AP003005.1  327049-328782 
           only 30% to 172A1 

CYP173A1   Mesorhizobium loti
           GenPept NP_105897
           NC_002678 complete genome 4126331..4127698
           100% match
  1 MDTQPAPFVP PAPKPRTSPP STLEMIRIVY RNPLELWGEP TYNEPWISAN GVGGHLIVAN
 61 DPGLIRHVLV DNAKNYKMAT VRQKILRPIL RDGLLTAEGE VWKRSRKAMA PVFTPRHIFG
121 FAQPMLKRTK EFVTRYEEGG ASDIAHDMTL LTYDILAETL FSGEIAGEPG SFANEIDRLF
181 ETMGRVDPLD LLRAPDWLPR LTRIRGRKTM AYFRKIVTDT VKMREEKFRR DPDAVPQDFL
241 TLLLKAEGPD GLTRSEVEDN IITFIGAGHE TTARALGWTL YCLAESPWER NRVEQEIDEV
301 LAREPDPTKW LDAMPLTRAA FDEALRLYPP APSINREPIE PEMWKDLYIP RHAAVLVMPW
361 VVHRHRKLWD RPDAFLPERF HPGNREKIDR FQYLPFGAGP RVCIGASFAM QEAIIALAIL
421 LSRFRFDTTA ETKPWPVQKL TTQPQGGLPM QVTPR

CYP173A2   Sinorhizobium meliloti 1021
           Genpept CAC41447                 
           NC_003047 65218..66618 = 173A2
           locus_tag = SMc02579
           62% to CYP173A1 Mesorhizobium loti
MDTRPEPFEPPAPVPRTGIPSRLEIIRTVLRNPLELWGEPSYTL
PWIETKFINQRTLIVNDPGLIRYILVENAANYEMSNVRRLILRPILRDGLLTAEGEVW
KRSRKAMAPVFTPRHAQGFAGQMLRVCEAFVDRYAGASSEPFVTNVAVDMTELTFEIL
AETLFSGEIAVEKQGFAANVEELLHRMGRVDPMDLLVAPSWVPRLTRIGGRKVLDRFR
GVVSETMSLRRRRTTEAPGDVPNDFLTLLLQLEGPDGLSTSEIEDNILTFIGAGHETT
ARALAWCFYCVANTPAYRETMEQEIDSVLASGADPVDWLGRMPHVLAAFEEALRLYPP
APSINRAAIEEDAWTSPEGERVPIRKGISVLVMPWTLHRHALYWQKPRAFMPERFLPE
NRDKINRFQYLPFGAGPRVCIGATFALQEAVIALAVLMHRFRFDLTDETHPWPVQRLT
TQPRGGLPMKVSARVK

CYP173B1    Magnetospirillum magnetotacticum
            GenEMBL AAAP01002719 
            42% to 173A1 missing N-term 91 aa
1466 NGLLTAEGDEWRLQRRTLAPIFSARHVAGFVAQMDAAGARLGRRLARRDGATVDIALEMT 1287
1286 RATLDVLERTIVHAKGLPGPIPDALGRAITRLLESVGPIDP 1164
1185 SDVFGFPAFVPRLGRLRAGRHCVSSRRW*HLLDGRKQALARGEAPHDLM 1015
1014 TLLLAAQDPETGRGLSDIEVKANIVTFIAAGHETTANALTWALYCLSQDGAARARVEAEA 835
 834 DAAAGPEGNLRLDRLPFTKAVMEETMRLFPPVPFLSRQALRDDRIGRVKIPRNSTVIV 661
 660 APWVMQRHRKLWDEPDAFIPDRFFGSRRESIERYAYLPFGAGPRVCIGQSFSVQEATLVL 481
 480 AHVARAVRFTLPDEHPPVTPLHRVTLRPKDGLRMVARRRM* 358

CYP174A1   Halobacterium sp. NRC-1 (Euryarchaeota; Halobacteria)
           GenEMBL AE004998 comp(560-1777) 
           only 33% to 171A1 

CYP174A1   Halobacterium sp. NRC-1 (Euryarchaeota; Halobacteria)
           AAG18971.1 GenPept,  AE004437.1complement(326955..328172) genomic
  1 MGPMETYVVT EPALVERLLV SDAAEFRKPE FQADAIDDLL GDGLLLSEGE SWREQRGRAN
 61 PAFSMARVAG FDADIAAHAA DRVDDWPVGD TVDVEAAMTH ITLDVILDVM LGVSLPEARV
121 DAIGDALEPV GARFEPDPVR FAVPEWLPMP DDREYAAAVA TLDDLVDDIV AAREGTASGG
181 DGDDPMDLLS VLLRARDRGE QSLDRLRDEV MTTLLAGHDT TALTLTYTWF LLSEHPDVEA
241 RLHAELDGAL DDGAQPTVAQ LQDLDYLEWV LQESMRLYPP VYNVFRTPIE PVELAGSEVP
301 AGAPIMLPQW AIHRSPDHWD DPEAFDPERW RPERRADRPR FAYFPFGGGP RHCIGKQLAL
361 LEAKLIVATV ASDYRLRYEG DTPLSFVPSL TIHPEQEMRM RVEPR

CYP174A2   Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)
           YP_134859, AAV45153 GenPept, NC_006396.1:56503..57840 genomic
           62% to 174A1 
  1 MSKTPPGPKG EPLFGSSRTY ARDPFRFISA LERAYGDVAR FDMGPMDTVM LCDPTAIERV
 61 LVSEADRFRK PDFQGDALGD LLGDGLLLSE GETWEQQRKL ANPAFSMARL SGMADRITGH
121 AEDRIADWSH GDVIDAEQSM TRVTLDVILD LMMGVELSEQ RVQTIEEQLL PLGQRFEPDP
181 IRFAMPQWMP MPDDAEFNRA VRTLDEVLDD IIEVREDSLG TDEDGPMDFL SVLLRARDDG
241 NQSPEQLRDE MMTMLLAGHD TTALTLTYTW FLLSEHPEVE QRVHEELDDV IGDDRPGMEH
301 VRELDYLEWV IQEAMRLYPP VYTIFREPTE DVTLSGYEVE AGTTLMVPQW GVHRSERFYD
361 DPETFDPERW KPERASERPR FAYFPFGGGP RHCIGKHLAM LEAQLITATT ASQYRLEFQG
421 ETPLELLPSL TAHPRQKMSM RVQER

CYP174A2   Haloarcula sp. LK1 (Euryarchaeota; Halobacteria)
           GenEMBL HM135515
           9 amino acid differences to CYP174A2 Haloarcula marismortui
           probable ortholog
           Lemoenkloof saltern, South Africa

CYP174A3   Halomicrobium mukohataei DSM 12286  (Archaea; Euryarchaeota)
           ZP_03873471
           72% to CYP174A2 Haloarcula marismortui
  1 MAETPPGPKG EPLFGSSRTY AQDPFRFVEA LEDAYGGVAR FDMGPMDTLL IAEPELVQQI
 61 LVDDDAKYRK PDFQDDALGD LLGDGLLLSE GDTWQEQRKL ANPAFSMARL ADMDDRIVDH
121 AESLVADWQD GSVVDAERGM THVTLDVILD LMMGVELPDE RVTTVQDQLV PLGARFEPDP
181 IRFAMPDWVP MPDDAEFDAA METLDGVLDD IFERRRGTTG DEDDGPMDFL SILMRARDRG
241 EQSDEQLRDE MMTMLLAGHD TTALTLTYTW FLLSEHPEVE QRLHEEIDAV VGDERPTIDH
301 VQELEFLDWV IDESMRMYPP VYTIFRTPTD PVELGGYDVA PSTNLMLPQW AVHHSERHWE
361 NPEEFDPERW SPERSEDRHR FAFFPFGGGP RHCIGKHLAL LEAKLIVATV AKDYRLRFEG
421 ETPLELVPSL TVHPRQEMSM RVEER

CYP174B1   Halorubrum lacusprofundi ATCC 49239 (Euryarchaeota; Halobacteria)
           ZP_02017101.1, EDN48184.1 GenPept, NZ_ABEB01000009.1 
           complement(36125..37534) genomic
           63% to YP_659381 Haloquadratum walsbyi, 53% to 174A1 with an insertion
  1 MSATPPGPIG DPVFGNGRQY ADDPFSFMRA CADSYGDVVR FDLGPRETYM LTNPADVERV
 61 LVADAERYRK PDFGDDAIDT LLGNGLLMSE GETWERQRRL ASPSFHSRRI GALAGTMVEH
121 TESQLADWAD GEVVDVQLEV ARLTVKIIVS AMFGADITDE EVKTVQEKLE PLGARFEPDP
181 RRFLIPNWMP TRENREFDAA IGTLESVIDG IVDRRRGTEY DPSVDPAGPG GVAVRGPVGD
241 GPDGDGAGDL PMDLLSVLLR ARDRGEQTDE NLRDELVTML LAGHDTTALA LTYTFYLLSN
301 HPEARERVAR EAAAATADGP PTAADAREMK FTERVLNESL RLYPPVYTLF REPKLDVKLG
361 GYRIPEGSAL MLSQWAIHRS PRWYDDPETF DPSRWEPERQ SKRPRFAFFP FGGGPRHCIG
421 KAFSLLEAKL ILAEVCSRYD LDYEGPDLSL RGSLTMHPDH PVPMRIRER

CYP174B2   Haloquadratum walsbyi DSM 16790 (Euryarchaeota; Halobacteria)
           YP_659381 GenPept, NC_008212.1:3112950..3114311 genomic
           CAJ53807 GenPept, AM180088.1:3112950..3114311
  1 MSTQPPGPNG VPVFGNSRQY ASDPFTFLRS VADAYGDVVR FSLGPLDTYM LTNPVDIERV
 61 LVTDDQKYQK PDFQDDAIGT LLGDGLLLSE GETWQKQRQL AQPAFGPKRI TSLAGTMTDH
121 TRGMLDGWEP GDIKDVHLEM ARVTVRIIVE AMFGTSLTDT QTTAVQENLE PLGKRFEPDP
181 LRFIIPDWVP TQENQEYHKS VSVLEDIIDE IVSERRGTET NSDIDPGAGS DDDPMDLLSI
241 LLRAKQRGEQ TDKQLRDEMM TILLAGHDTT ALTLTYTWYL LSEHPKVRDQ VHEELASVCG
301 GETPTMADTR SLDYTERVLQ ESMRMYPPVY VIFREPQVDV RLGGYRIPAG SAIMLPQWVV
361 HRSPRWYDNP TTFDPDRWRP ERRADRPRFS YFPFGGGPRH CIGKHLSMLE AKLILGTVAQ
421 SYELDYVRDR PFDLRGSLTM HPDEPMGMRV TER

CYP174B3   Halobaculum gomorrense (Euryarchaeota; Halobacteria)
           GSS sequences BZ894476.1, BZ894445.1
           54% TO 174A1, 60% TO 174B2, 66% TO 174B1
           These two sequences do not overlap but they are
           Most likely from the same gene
GRAGDLGRRRPHRRATGARAAHRPDHRHRDVGTDIDEETVRAVQENLEPLGQRFEPNPMR
AVIPNWAPTRENRRFDDAVATLEGVIDDLVARRRGTEETAPDPAGDAVDSPMPMDLLSIL
LRAHDRGDQTEGDLRDELMTMLLAGHDTTALALTYTFYLLSKHPEAKARFQREVDALDGT
PTAADLRDLSFTDRVLSEAXXXXXX
VYTLFRESKVDARVAGYRIPEGSLIMLPQWVVHRSDRWYDDPLAFDPDRWAPGRRADRPR
FAYFPFGAGPRHCIGKQFSLLEAKLILATVGRAFDLEYEGPELDLRGSLTMHPDHPMPLR
LSSR*

CYP174B4   Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
           ZP_03998664, EEJ57769, ABTX01000001.1 1368411-1369736
           76% to CYP174B2 Haloquadratum walsbyi DSM 16790 (Euryarchaeota; 
           Halobacteria)
  1 MPLFGNSREY AKDPFTFLRQ VSEAYGDVVY FGLGPLDTYM LTNPADIERV LVSEDAKFHK
 61 PDFQDDAIGT LLGDGLLLSE GETWRKQREL AQPSFDPRRI AALGETMTDH ATAMVEGWND
121 GEVRDVQLEM ARVTVKIIVD AMFGSSLADE RVRTVQENLE PLGKRFEPDP LRFLIPDWAP
181 TRENREYKQS ISILEGIIDD VVAERLGTEN DPSAAVAGED GAPMDLLSVL LRAKQRGEQT
241 DQQIRDEMMT MLLAGHDTTA LTLTYAFYLL SQHPESEAKV QAEVDKVCGG ETPTVADVRQ
301 FDYLERVLQE AMRLYPPVYV IFREPQVDVR LGGYRIPSGS AIMLPQWVVH RSPRWYDAPT
361 EFDPDRWRPE RRASRPRFSY FPFGGGPRHC IGKQFSMMEA KLILATVAQA YELDYVRDRP
421 FSLRGSLTMH PEEPMGMRLR AR

CYP174C1   Halomicrobium mukohataei DSM 12286  (Archaea; Euryarchaeota)
           ZP_03874667
           42% to CYP174A2, 41% to CYP197C1, 41% to CYP1002A1
  1 MTTTDAPGPR GLPVIGNSHQ WARDPCAFRE RCAAEYGPVV NYEMLGWDTY MLTDPADVKR
 61 VLEDPDTFPK HEPSNAQLEA FVGNGLLTSG GDLWERQREA IQPAFYMDHI RNYAERMVAQ
121 AAATADRWTA GESVDVRRAM TRCTLDILVD CLFGQEIDPA ERGLYEAVEA FQAPLEPSKQ
181 PITFFAPDWA PVPFLRRADR ALSHIDDQIY DIVETRRADE ADRDDLVAML IAADTAMDDE
241 QIRDELVTFL FAGHETTALS MTYVWDLLSR NPTAQRRLHE ELDALLDGRP TIEDVFDFEY
301 TGAVIEEAMR LYPPAHDIRR SPATTVEIGG YTIPEGSLVT LPTWVLHRDE RFWDDPEQFR
361 PGRFLDGGRS DRPEYAYFPF GGGPRRCIGQ QFAMTEAQLI LATIASEWTL EREYGDLELS
421 AAVTLQPSHD VAMTPHRRD

CYP175A1   Thermus thermophilus
           GenEMBL AB001637 N-terminal 30 amino acids only 1587-1677
           AX451783 full seq
           Francesca Blasco francesca.blasco@po.uni-stuttgart.de
           Full sequence submitted to nomenclature committee 9/17/2001
           Crystal structure known

CYP175A1   Thermus sp. NMX2.A1
           GenEMBL GU220073
           6 amino acid differences to CYP175A1 Thermus thermophilus
           probable ortholog from Jemez Springs, New Mexico

CYP176A1   Citrabacter braakii
           GenEMBL AF456128
           David Hawkes and James De Voss, University of Queensland, Australia
           Full sequence submitted to nomenclature committee 11/15/2001
           P450cin involved the hydroxylation of cineole

CYP177A1   Rhodococcus rhodochrous strain 11Y
           GenEMBL AF449421
           Seth-Smith,H.M., Rosser,S.J., Basran,A., Travis,E.R., Dabbs,E.R.,
           Nicklin,S. and Bruce,N.C.
           Cloning, Sequencing, and Characterization of the
           Hexahydro-1,3,5-Trinitro-1,3,5-Triazine Degradation Gene Cluster
           from Rhodococcus rhodochrous
           Appl. Environ. Microbiol. 68 (10), 4764-4771 (2002)
           submitted to nomenclature committee 7/30/2002
           degrades an explosive to confer RDX degrading phenotype
           alternative name XplA (for explosive gene A)

CYP178A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV838

CYP179A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2061

CYP179A2   Streptomyces scabies
           SCAB19191
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           74% to 179A1 with insertion Streptomyces avermitilis

CYP180A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2165

CYP180A2    Saccharopolyspora erythraea NRRL23338
            SACE_3525, se: 3884312,3885574 (-) STRAND, 
            61% to CYP180A1
VTATGVPDVFDPRRYSSGIPHADFAWLRANAPVSWQPEHAVGDWPAGPGFWAVTGYDDVV
RVLRSPGEFSSWLGATQIRDPAPADLPFIRRMMLNLDPPEHGKLRRIVSRAFTPRRVERF
RAEVAARARRLVDAVAERGGCDVPPDLTDDFPLLNLADLMGVPEADRRMLLEWTNRIIGY
QDPEHSEVVRDADGRPLNPRSPAMLADMFGYAQELAAHKRRHPADDLMTALATAEVDGGR
LSGAELEMFFFLLSVAGNDTVRSALPGGLRAFAEHPGQHRLLLESPELLDRAIEETLRYH
PPVLSFRRTATTDVELAGQAIPVGAKVVVFHCSANFDPARFDDPLRFDIRRDPNEQLSFG
TGPHVCLGAHFARLQLRAFYSEALWRLRDLHVTGPVRHLVSNFINGIKHLPVAFTAVRPR

CYP180A3   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_2082
           51% to CYP180A2 Saccharopolyspora erythraea NRRL23338 
           54% without 21 aa insertion
           missing about 5 amino acids at N-term

CYP180B1   Streptomyces scabies
           SCAB9651
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           41% TO 180A1 Streptomyces avermitilis, 
           40% to CYP125A2 Streptomyces avermitilis NOTE: CYP180 AND CYP125 ARE           
           QUITE CLOSE AND MAY BE LIKE SUBFAMILIES OF A SINGLE FAMILY.

CYP181A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2385

CYP182A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2806

CYP182B1   Streptomyces scabies
           SCAB81761
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           47% to 182A1 Streptomyces avermitilis

CYP182C1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2935 48% to CYP182B1

CYP183A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV2999

CYP183A2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_10598
           72% to CYP183A1 Streptomyces avermitilis  

CYP183B1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0281
           45% to 183A1

CYP183C1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7103
           43% to CYP183B1 Mycobacterium marinum MM0281 

CYP183D1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7104
           44% to CYP183A1 Streptomyces avermitilis 

CYP183E1   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7185
           43% to CYP183B1 Mycobacterium marinum MM0281  

CYP184A1   Streptomyces avermitilis
           No accession number
           Submitted by David Lamb and Haruo Ikeda 9/3/02
           Clone name SAV5111

CYP184A2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_734
           65% to CYP184A1 Streptomyces avermitilis 

CYP185A1   Mycobacterium smegmatis
           MSMEG0814 TIGR
           59% to CYP185A5 Mycobacterium vanbaalenii
           57% to CYP185A3 Mycobacterium avium subsp. paratuberculosis
           52% to CYP185A2, 57% to 185A4, 66% to 185A5, 54% to 185A6
MRADTRFMVETASPPLTELPLAPRNTLPCREQIRCLRSFIDGMQRLRDVGGPVTRIV
LGPRWLVPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQLQRLMGGNLL
DLPHDRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWADGATVDLD
RACRALTLRALGRSVFGVDLDQRAEDVGPALRTSLSWVADRASRPVNLPQ
WVPTRGQRKARAGNATLHRLAAEILADVRADPDRDAPLVRALLEARDPET
GRGLTDDQICDELVLFMLAGHDTTSTTLCYSLWALGHHPDIQERVYAEVA
ALGDRELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMTVDGYRV
EAGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAGRNRWQYLPFGGG
PRSCIGDHFAMLEATLALATVIRAVSVESQNTDLPVETPFTVIAAAPVPA
RVTRR

CYP185A2   Mycobacterium smegmatis
           MSMEG0958 TIGR 
           52% to CYP185A1
           71% to 185A6, 59% to 185A5, 57% to 185A3, 53% to 185A4
MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVRAL
DMGQQVIRAAGGAVTRVQFGPRWLVPPLVAVFSPEGIRDVLGRNDAFAER
CIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTKHSVRAFGGHMSRAA
QTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGRSVLGIDLNERADVIV
EHMHVASSYATDRALRPLRAPRWLPTPARRRARAAVAAMRAVTAEILQAC
RDDADRDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATAL
TYALWALGHHPEIQDRVAAEARALGDRELTPADVPQLGYTVQVLHESLRM
CPPAAGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPDPEVFDP
DRFSPENSRERDRWHFIPFAGGARACIGEHFARLETTLALATIIRSVVVG
SVDAEFPVDVPFTTVAKGPIRANVAPRGPDHYTL

CYP185A3   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017231.1 
           CDS 236434..237804
           Name changed from CYP277A1
MSVAEPKRDIAGLPLAPKNPLSYRERLRAIKEFHTGTNKLRDAG
GPVTRVTLGPRWLISPIVLATSPQGIRDIVSVRDGSIDKTSTVATELRRLLGPNLFVL
PHTEWLPRRRTLQPVFTRQRVREFGGHMAEAAESVCAGWPEDTEIDLDAQCRTLTLRA
LGRSVLGLDLDERSDAIAEPLRVATSYAVRRALRPLRAPEWLPTPSRRRARAAAGAIR
ALADEILQACRADPGREAPLVHALIAATDPETGQALSDKEIRDEMIIFLFAGHDTTAT
TLTYALWALGRHPEYQARVAAEVAELPDRHLTPDDVARLGFTVRVLQEALRLCPPGPT
GTRMATRDVEVAGYRVEAGTMLAFGRMAVQTDPSLWDAPLRFDPDRFDPRRAGDRDRW
QYLPFGGGPRSCIGDHFAMLEATLALATIVRRVEIESLSDDFPLAVPFTMVAAAPIRA
MVRRRR

CYP185A4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0852
           58% to CYP277A1 Mycobacterium avium subsp. Paratuberculosis
           35% to 184A1
           Name changed from CYP277A2

CYP185A4   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 277A1 M. marinum = ortholog
           Name changed from CYP277A2

CYP185A5   Mycobacterium vanbaalenii PYR-1 
           ZP_01204630.1, EAS25622.1 
           59% to Msmeg_CYP185A1
MVGTVEREDLGALPLAPRNPLPYRQQVRAIRTFHTGLETLRDAGGPVTRLKLAPKWLMPPMVVATSPQGA RDILARGGGHIDKTRVHHEMRRLLGANLFDLTHEPWLPRRRALQPIFTKQHVREFAGHMATAAQTVADSW ADGTELDLDTECRKLTLRALGRSVLGLDLDEHSDAIAEPLRTALEYIADRALQPISAPRWLPTPARRRAR AASSTLHKLADKILQACRTDPTRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYA MWALGHHHDVQDRVRAEVVGIGDRELTPEDVPALGYTIQVLHEALRLCPPAAATARMAMRDVEVDGYRIE AGSMMAVGIYALHRDPALWERPLVFDPDRFSAQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLALATI IRSAEIRSSDPHFPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR

CYP185A6   Mycobacterium vanbaalenii PYR-1 
           ZP_01204233.1, EAS25225.1 
           71% to CYP185A2
           54% to 185A4
MTARDTAAAPEVGSLPLVPRNPLPLWKLVQLVRRLDTGQEVIRDAGGPITRIQLGPKKLMPPIVAVMSPA GMRDVLGRNDASSDRCIIHEQVQEMAGDSLWVLPNEQWRPRKRALAPVFTKTSVRAFGGHMSKAAQAFVD RWPSGGEVDLDAECRRVAMQSLGRSVLGVDLNERGETIARCMHVASSYTADRALRPVRAPRWLLTPARQR ARSAVNAMRAITDEMVKACRDDPTRDAPLVQALIAATDPETGRPLTDEEISNDLLIFMLAGHDTTATALT HALWVLGHHPDIQDRVAAEAAAIGDRELTPDDVPALGYTVQVLHESVRLCPPAAGVARLVTRDFAVDGYR VEAGSLVALGLYALHHDPALWPDPMAFDPDRFSPENVKARDRWQFLPFLGGGRPCIGEHFARLETTLALA 
TVVRACRIESLDDLFECEVPLTTVAKGPIRARVTPRR

CYP185B1    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            51% to CYP185A5 Mycobacterium vanbaalenii PYR-1

CYP186A1   Mycobacterium  smegmatis 
           MSMEG1773 TIGR 
           65% to CYP186A2
MSDGGHQLRGAQALATLVDLGFPAIASGVIARRPPVLGLLERMQADERAGRR
MHRLRSEFGRGPVELVIPGRRIVVVTDPEDVAAVLVQAPEPFHPANRE
KRKALQWFQPHGVLISQGPIREQRRTVNEAALDSGAAMHRLAESFAAKVA
AEADTLVARTLPGQRLDADEFMTAWWRLVRRLTLGERARDDHAITDQLAR
LRRAGNWSFLSLPHYRARSRFLSHLYRYAEDPEPGTLVGALADVPAGGAV
DPVGQIPQWLFAFDAAGMALLRALAVLATHPLQRDRALEDAGEPNRPLLR
PYLRGCLLESVRLWPTTPAILRDTTEDTHWREGAERFTVAKGAGLLIVAP
AFHRDDQVLPFAHDFVPEIWIDGRAQLYPQLVPFSAGPAECPGRNLVLFT
TSTLAANLLNRLHFDVRSEPRPVPGEPLPMTFNHAGIEFSLRPARRAVTA
ATVDPAT

CYP186A2   Mycobacterium sp. JLS 
           ZP_01278281
           65% to MSMEG1773 CYP186A1
MGASGRRLTG ARAAATLADL GPASTAARAV RRMQQLREQF GAGPVELVLP GRRMVVVLDP
DDVRRVLAGA PEPFHPANRE ERKSLEWSQR RDLDDAALDS GAEMHRLAGA FGDVIAAEAR
ELTDEVTARG TMDANQFMAA WWRIVRRIAL GDRARDDDEI TDALLRLRRA RNWSFLSMPH
YRTRARFLER LYDYVEDPQI GTLAAAVPAS GAVDPVGPLP QWLFAFDAAG IAQLRALAVL
ATHPAAMARA IEDAAEPDRL RLRPFLRACV LESVRLWPTT PTILRETTEK GAGLMIVTPA
FHRDPKLLPF ANDFVPDIWL DGRARSYPQL VPFSAGPAEC PGRNLALFTT STLLANLLSA
LDFRISSMPH LSPDEPLPVT LNQHGLEFAV VTAPRWRHHR AGSAVRS

CYP186A3   Nocardia farcinica
           AP006618.1, YP_120573.1
           65% to MSMEG1773 CYP186A1
4523238  MSGRHPETVARDQDERSPAPVPTS
4523166  AEHGRRLDGTRAVAALTDLGFAAIAAGVIARRRPVMGLLEKAQADSRALQRMRQLRREFG  4522987
4522986  AGPVELVVPGRRIVVLLDPGDVGRVLAEAPTPFHPANREKRAALRQFQPHGVLLSKGVVR  4522807
4522806  EQRRAVNEAVLDTDAPLHRLAEPFAAIIADEAAQLMASALQRGHLDAEHFTIQWWRMVRR  4522627
4522626  LVLGERGRDDSAITDELWRLRSAANWSFLAPPHRRRREVFTEQLYRYVERPDPNSLAGAV  4522447
4522446  AAVQTGGAVDPVGQIPHWLFAFDAAGMAAQRALAVLATHPDQQAAATADAADPHQVHLRP  4522267
4522266  YLRACVLESVRLWPTTSTILRDITEPTQWRAGADAFTIAPGAALLILVPAFHRDADLLPF  4522087
4522086  ADRFAPEIWLDGQAAQYPQLVPFSAGPAECPGRNLVLFTTSTLLAHLLAAAEFRLRSGHR  4521907
4521906  MSPQTPLPLTLNNFGLDFDVTRLPNVAS*  4521820

CYP186B1    Saccharopolyspora erythraea NRRL23338
            SACE_2090, se: 2276121,2277467 (+) STRAND
            49% to CYP186A3 AP006618.1  Nocardia farcinica = YP_120573.1
MTPKVSAALTTGVRTASPTDTARVAAQVVLPALATGVISRRPRVMALAERLRADRRAVGL
LRELRSRYGAGPLRLRVPGRDVVLVLSPEHVRRVLVSDAESFTPANREKQAALGHFQPHG
VLLSRGLDRARRRQFHEHVLETREHAHHLAPRFIQVVREEARVLLDEAERTGSLDWQTFG
AGWWRVVRRIVLGDQARDDRELTGELDALRSDANWAFLSPKRLSLRRDLRARLREHLRRA
EPGSLAETVARAETPVQAPEEQVPHWLFAFDAAGMAAFRALALLAAQPEQAARARSEIAE
SDLATPQPLHHLRACVLDALRLWPTTPMLLRDSVEETAWDGRQLPAGTAFLVFAPLFHRD
ETAADFAHAFTPEAWLDGRAEHHSALVPFSAGPGRCPGENLVLLVTSTLLAVLMRDAEFE
PGEGPALGPQGPLPATFDNFHTTVRLAR 

CYP186C1    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            50% to CYP186A3 Nocardia farcinica

CYP187A1   Mycobacterium smegmatis
           MSMEG2245 TIGR 
           35% to 159A2
           78% to CYP187A6 Mycobacterium vanbaalenii
           77% to CYP187A2 Mycobacterium avium subsp. paratuberculosis
MDSRIRDDPAVDTAALLRDPYPIFARYRAQAGVFRGSVMDWSKTPKELMP 
EHQYAAMSFDAVNTVFRDGKTFNSKIYDSTIGLFIGPSILAMEGKTHRDH 
RNLVSAAFKSKSLARWEPEIARPICEALVDEFVDTGSADLVRDYTFEFPT 
RVISKLLGLPEEDLPWFRRRAVELISYSVKYKRAFEASAALKDYFLDQIE 
RRRSRPTEDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGN 
LLYLLLTHPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELE 
GVQIPAGAVIDVCIGSANRDENRWERPEEFDIFRKRIPHITFAAGEHTCM 
GLHLARMETRVAMETLLNRVTDLRLIADDDPHIFGQPFRSPTAIPVTFRPAG

CYP187A2   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017235.1 
           CDS 255472..256674
           Formerly CYP273A1
MMTNVPTAAGDETVSLRDPYPFFARKRREAGVFAGTVMDYSKTP
ESLMPKQEYSAVSFDAVNTVFRDGRVFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNL
VSAAFKSKALARWEPTIVRPICNALIDDFIDAGTADLVRQFTFEFPTRVIARLLGLPD
EDLPMFHTRAVQLISYHVDYERAFEASAALKDYFLEQIEQRKSKPTEDIIGDLVTAEI
DGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPDQFAALQADRELLAPAIE
EGLRFETPLTTVQRFTTEDTELQGVRIPARSVIGVCIGSANRDERRWERSEEFDIFRK
HVPHISFAAGEHTCLGLHLARLETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTA
LPVTFDAK

CYP187A3   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017235.1 
           CDS 236687-237919
MPLSTGPTGQPVVPTLDFTGETSPYPFFEHMRRTDPVWHGSLAD
ASQLPEELRPEDEWVLFDYESVSQAFRDDRIFSSHKYDETIGLVMGHTILAMGGREHH
DHRNLVAKAFRATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTL
LGLPAEDLDLFRRLSLDLISIPTDIEAGLNAATELYDYFLKQVEQRRRKPTDDIIGDL
VAAEIDGEKLTDEAIIAFLRLLLPGGLETTYRSSGNLLYLLLTHPEQLAMVYRDRSLI
PMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAF
DIRRPRQAHIAFAGGIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIV
GLTFRSPNKLPVTFAPAA

CYP187A4   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3996
           85% to CYP187A2 Mycobacterium avium subsp. Paratuberculosis 
           57% to CYP187A3 Mycobacterium avium subsp. Paratuberculosis 
           38% to 159A1, 38% to 159A2, 57% to 187A5

CYP187A4   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 187A4 M. marinum = ortholog

CYP187A5   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4008
           82% to CYP273A1 Mycobacterium avium subsp. Paratuberculosis 
           56% to CYP273A2 Mycobacterium avium subsp. Paratuberculosis 
           36% to 159A2, 57% to 187A4

CYP187A5   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 187A5 M. marinum = ortholog

CYP187A6   Mycobacterium vanbaalenii PYR-1 
           ZP_01203863.1, EAS24855.1 
           78% to 187A1, 35% to 159A2
MDQRPGRARRFGVRHVDDGGHSDRAVARRCTGKYCKRYSNEMETPVQDLAKDEPIDLRDPYPMFARRRAE GGVFRGSVMDWSRTPDSLRPENLYAAVSFDAVNRVFRDGKVFNSHIYDSTIGLFIGPTILAMEGKTHWEH RNLVSAAFKTRSLARWEPEIVRPVVNELIDEFIDDGRADLVRDFTFEFPTRVISRLLGLPEEDLPWFRKR AVELISYAVNYKKAFEASAALKDYFLGQIDKRRSAPTEDIIGDLVSAEIDGERLTDEAIFSFLRLLLPAG LETTFRSSGNLLYLLLTHRDQFEAVNADHALIGAAIEEGLRYETPLTTVQRFANEDTEIDGVEIPAGSVI DVCIGSANRDESRWERAEQFDIFRTRTPHISFAAGEHTCMGLHLARMETRVAAETLLSRLSAIELLTDGD PHIHGQPFRSPTALPVTFTPSRARP

CYP188A1   Mycobacterium smegmatis
           MSMEG4791 TIGR 
           87% to CYP188A4 Mycobacterium vanbaalenii
           65% to CYP188A5 Mycobacterium vanbaalenii
           72% to 188A3 
MSIQDVTTDDDREKITYHFDRHTPEYRLQFEKITEEMHSRCPVAWTETYD 
GHWVAAGSNEVFELARCPVVSNHHDISGETPFQGITIPKASRATVVRGGI 
LEMDEPEHSAYRGALNPYLSPAAIKRWEPFVDEITRAAIDEHISSGRIDF 
VEHLANVVPAVFTLAMMGIELKKWNVYSEPTHASVYTPEHAPEREKINEQ 
HREMGIDLINNMMEIRQNPRPGLVNALLQL 
RIDGEPAPDMEILGNLGLII 
GGGFDTTTALTAHALEWLGEHPDERERLSRERDTLLNPATEEFLRFFTPA 
PGDGRTFAEDAEVAGYKFKQYERLWLSWAMANRDPSVFDKPNEVILDRKG 
NRHFSFGIGVHRCVGSNVARTVFKSMLTAVLDRMPDYVCDPEGTVHYDTI 
GVIQGMRNLPATFTPSRPLGPGLDETLEKLQRICNEEELARPITERKERA 
VID

CYP188A2   Mycobacterium avium subsp. Paratuberculosis
           AE017229.1 CDS complement(173813..175057)
MPDAWTDTYGGHRVAAGSHEVFELARCPAVSNDHDINGERRGYK
GISIPTASRVSAVRGGILEMDDPEHRIYRTVLNPYLSPAAVKRWEPFIDEVTRAALDE
KIEEGSIDFVDDLANIVPAVLTLAMLGIPLKKWKMYSEPVHAAVYTPEHSPDIERVTA
MHREMGLDMVNNMLEIRENPRPGIVNALLQMRIDGEPAPDLEILGNLGLVIGGGFDTT
TALTAHSLEWLSEHPEQRQLLSDERKTLLDPATEEFLRYFTPAPGDGRTFSEDFELDG
TVFKEGERLWISWAMANRDPAVFHDPDEVILDRKGNRHFSFGLGIHRCIGSNVARTVF
KSMLIAVLDRMPDYRCDPEGTVHYETIGVIQGMRKLPATFTPGRRIGAGLDETLEKLQ
RICDEQELARPITERKEAAVID

CYP188A3   Mycobacterium marinum 
           Tim Stinear
           MM4717
           86% to CYP188A2 35% to CYP222A1 Thermobifida fusca

CYP188A3   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 188A3 M. marinum
           36% to CYP243A1 Mycobacterium avium
           formerly 281A2

CYP188A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01205759.1, EAS26751.1 
           74% to 188A3
MSVDDVVSGTADDSRKQNRYYFDRHTPEYRLQFEKITEEMQTKCPMAWSDTYGGHWVAADSKHVFELARC PVVSNHHDISGETPFQGITIPKASRATVVRGGILEMDEPEHSAYRGALNPYLSPAAIKRWEPFIHEITRA ALDEHIESGRIDFVDHLANVVPAVFTLAMMGIKLDKWNVYSEPTHASVYTPEHAPEREKINEQHRAMGLD LITNMMEIRENPRPGLVNALLQLRIDGEPAPDIEILGNLGLIIGGGFDTTTALTAHALEWLGEHPDQRQR LSSERATLLDPATEEFLRFFTPAPGDGRTFADDVEVEGQRFKKFERLWLSWAMANRDASVFDRPNEVVLD RKGNRHFSFGIGVHRCVGSNVARTLFKSMVTAVLDRMPDYVCDPEGTVHYDTIGVIQGMRNLPATFTPGK 
RLGPGLDETLEKLQRICDEQELARPITERKEAAVID

CYP188A5   Mycobacterium vanbaalenii PYR-1 
           ZP_01203997.1, EAS24989.1 
           68% to 188A3
MADQLDRRREARSFHFDRHTPQYRDRFQEITAQMQARCPLAWTDTYGGHWVAAGNREVFELARCPHVSND NDIDGTRRGYTGINIPRGDYSVAFRGGMLEMDDPEHREYRSPLNGYLSPAAVRRWVPVVDELVKACLDEK IEDGRIDFVDDLANIVPAVLTLGLLGVPLKDWEIYCEPAHASVYTPADSPDFPRVADLAIASAMGMMHHV AEIRQTPRPGLIDALVRTRIDGQPAPDTEIMGMLMLLIGGGFDTTTALTAHALEWLSQHPDERERLSRDR DTLLDPATEEFLRYFTPAPGDGRTVAEDIEVDGVVLKEGERLWLSWAMANRDPALFQNPDEVVLDRKGNR HFSFGLGVHRCIGSNVARTVFKSMLTAVLDRMPDFQCDAAGAVHYETIGVIQGMQHLPAAFTPGPRLGPG 
LEATLEKLQRVCDEQQLAAPITVHKAAAVI

CYP189A1   Mycobacterium smegmatis
           MSMEG4818 TIGR
           64% to 189A2, 52% to 189A3 52% to 189A4
           64% to 189A7
           82% to 189A9 Mycobacterium vanbaalenii
           53% to 189A8 Mycobacterium vanbaalenii
MPPFDDGVPMAQPSTSATPDLYYDPYSVQLNMEPHEVFARIREEAPLYYN 
EQHDFYALSRYHDVNKAVIDHETFISGRGALLELIKSGMEIPPGTLIFED 
PPIHNIHRNLLSRMFTPRKVLALEPQIREFTTRCLDAVAGSDTFDFVNDL 
GEQMPMRVIGMLLGIPEDRQRAITDHGEETLQGTTVDSLATGEVFAEFID 
WRADNPSDDIMTDLLNAEFEDETGTVRKLRRDELLLYLTVIATAGSETTT 
RALGWAGKTLADHPDQRRDLVENPALIPQAIEELLRWEPPALQIARYVTR 
DVEYYGKTVPAGSAMLMLVGAANRDHRRFPPNGDVFDIHREQFSHMTFGA 
GTHFCMGNALARLELRVALEEILKRFPEWEVDWDNARPSETAAVRGWAAM
PTFVR

CYP189A2   Mycobacterium smegmatis
           MSMEG4873 TIGR
           64% to 189A1, 59% to 189A3, 55% to 189A4
           72% to 189A7
           61% to 189A9 Mycobacterium vanbaalenii
           58% to 189A8 Mycobacterium vanbaalenii
MTASATQNVYFDPYDVAINADPYPTFARLREEAPLYYNEQFDFYALSRFS 
DVNKALIDHETFSSARGAIVELIKADIEIPSGALIFEDPPIHTAHRKLLS 
RMFTPRKINALEPEIRRFCAQSLDAVAGVERFDIIKDFGAIMPMRVISAL 
LGIPEEDQEKIRDHGNAQMRTEAGKPMKAAEEGLVDGSIFEAYIDWRKDN 
PSDDIMTELLNVEFTDEHGVTRNLTREELLIYINVVAGAGNETTTRLIGW 
AAKTLAEHPDQRRQLVENPALIPQAIEEILRFEPPAPHVARYVTRDVEYH 
GRTVPEGSVMMLLIGAAVRDSRQFPPDGEVFDINRAPRQHLAFSVGTHFC 
LGSALARLEGRVALEEILKRFPEWDVDLASAELSPTSTVRGWDSLPVIVR

CYP189A3   Mycobacterium smegmatis
           MSMEG3700 TIGR
           59% to 189A2, 57% to 189A4 52% to 189A1 
           86% to 189A8 Mycobacterium vanbaalenii
           50% to 189A9 Mycobacterium vanbaalenii
           83% to 189A6
MTVDDSGVVVTGVAGPYYDPYDVGIVADPYPVYARLRDEAPLYHNERYGF 
WALSRHADVESALANWETFSNSRSDILELVKSDFDMPPGVMMFTDPPMHT 
MLRGLMSRVFTPRRMAEIEDQIRRYCVRCLDPLVGSDRFDIIAELASTMP 
MRVIGMLLGIPESEQIGVRDANDANLRTKPGAPMKVAQADKIADGRIYAD 
YVEWRSKNPSDDLMTALLGVEFTDEHGVTRKLTRKEVLHYTQVVAGAGNE 
TTGRLIGWLAKVLAEHPDQRRQIEQDRSLLTRAVDETLRFEPTGPHVARW 
VARDFEAYGQTVPAGSAMLLLFGAANRDPRRYTDPDVFDIHRDNISHLTF 
GKGLHYCLGANLARLEGRVALDELLNRFPEWDIDYSTARLAPTSTVRGWE
RLDVLVG

CYP189A4   Mycobacterium smegmatis
           MSMEG6584 TIGR
           57% to 189A3, 55% to 189A2, 40% to CYP123
           58% to 189A8 Mycobacterium vanbaalenii
           53% to 189A9 Mycobacterium vanbaalenii
           57% to 189A7
MRVLDELSYDPYDVEIDVDPYPTYRRLRDEAPVYFNGRFGFWALSRFADV 
EAALRDVDNLSNAKGDILEVVKAEPKMPLGVFINEDPPLHTVHRLLVSRA 
FTPRKMRAIEDQIRTFCAACLDPLTSGDRFDFTLDLGAEMPMRVIGMLIG 
IPEELQRSVRKVAGQRLRNKPGEPLPVNKDNYFNGNMFRDYVEWRAQNPS 
DDLVTELLNVEFEDVTGTTRKLSSEELLVFLGVIANAGTETVGRLFGWLG 
KLLGEHPDQRRALVADPSLIPGAVEEVLRYEPPVHNIARYVSADVDYHGQ 
TIPAGSALLLMTGAANRDERRFDDPDRFDIRRSPNHLSFGRGAHFCLGAS 
LARVEGRVALEEILKRWPDWTVDMGNAVRAPTATVRGWDSMPAIVG

CYP189A5   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017234.1 
           CDS complement(151992..153206)
MVMTGTSAIELYYDPFDSGIDDNPYPVWQRMREEAPLYYNEKYN
FYALSRYEDVARELPNWQTYRSGRGTTADILFSNVEVPPGILLFEDPPLHDLHRRLLS
RVFTPRRMLAVEDLVRGFCVRELDPLVGAGGFDFIRDLGAMMPMRTIGYLLGIPEEDQ
EKIRDRSVANIELSRDSDPAAVDANVFANSIALFADYIEWRADHPSDDLMTELLRAEI
DEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQLLSDHPDQRRELAADPSLI
PGAVEETLRFEPPSPVQARYVARDAEHYGRVVPEGSFMLLLNGSANRDPRRFTDPDRY
DIHRQGGGHLSFGQGLHFCLGSALARMEARVAFEEVLKRWPDWEVDYANAERARTASV
RGWARLPVVTGG

CYP189A6   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0928
           57% to 189A7
           52% to 189A5 Mycobacterium avium subsp. Paratuberculosis
           37% to 123A1 

CYP189A6P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 189A6 M. marinum in conserved region = ortholog

CYP189A7   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4753
           57% to CYP189A6
           54% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
           37% to 123A1 

CYP189A7   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 189A7 M. marinum = ortholog

CYP189A8   Mycobacterium vanbaalenii PYR-1 
           ZP_01203775.1, EAS24767.1 
           82% to 189A6, this seq is short at N-term  
MADDLYYDPYDQGIVADPYPTYARLRDEAPLYYNGRYDFWALSRHADVEKALQDWSTFSNSRSDILELIK SDFDMPKGVMMFEDPPEHTMLRGLMSRVFTPRRMAEIEDQIRRYCVNCLDPLVGSDGFDVIAELAAMMPM RVIGMLLGIPESEQVSVRDANDANLRTRPGAPMKVADPDRIADGRIYSDYVEWRAANPSDDLMTALLNVE FTDEAGVHRKLTRKEVLHYTQVVAGAGNETTGRLIGWLAKVLAEHPQQRREIVEDRSLLGRAVDETLRFE PTGPHVARYLARDFEYDGTTVPAGSAILLLFGAANRDERRYRNPDTFDIHRDNISHLTFGKGLHYCLGAN LARLEGRVALDELLNRWPEWNIDYDTARLAPTSTVRGWEHLRMLVG

CYP189A9   Mycobacterium vanbaalenii PYR-1 
           ZP_01205817.1, EAS26809.1
           35% to 123A1, 82% to 189A1, 66% to 189A6
MTISADDSDVQNADTAAELYYDPYNVDLNMDPHGVFARLREEAPLYYNDKHDFYALSRYEDVNKGVIDHQ TFISGRGALLEIIKSGMEIPPGTLIFEDPPIHNIHRNLLSRVFTPRKVQALEPQIREFTARCLDPLTGTN RFDFVRDLGAQMPMRVIGMLLGIPEEDQRRVTDHGEATLQSDSVDLMATGEVFAEFIDHRTEHPSDDIMT DLLNAEFEDETGTRRRLRRDELLMYLTVIATAGSETTTRLIGWAGKTLADYPEQRAQLVADPALIPQAIE EILRWEPPALQIARYVTRDVEYYGQVVPEGSAMLMLVGSANRDHRRFPPNGDVFDIHRELRSHMTFGAGT HFCMGNALARLEGKIALEEILKRFPTWEVDWPNAVPSQTTAVRGWESMPTIVS

CYP189A10  Frankia sp. EAN1pec
           YP_001507240.1 
           ABW12334.1
           61% to CYP189A7 Mycobacterium marinum
MSLLRSKDIYYDPYDAQIDSDPYPVWRSMRNEEPLYYNEKYDFYALSRYGDVDACLSDRATYRSGRGSIL
EIIKANIEFPPGMILFEDPPIHDVHRGILARIFTPKKMNALESKVREFCVRSLDPLVGSGRFDFVEDLGA
QMPMRTIGFLLGIPEKDQEAIRDHSNAGQRLDEGQEPTVREPNGEHFEAYIDWRAEHPSDDLMTELLHAE
FDDETGTRRRLSRSEVLLYIQMLAGAGNETTTRLIGWTGKVLGEHPDQRREIAADRSLIPQAIEELLRYE
APSPVQARYVARDVEHYGRTIPENSAILLLNGSANRDERQFPDGDRFDIHRRRSRHLSFGYGIHFCLGAA
LARLEGRVALDEVLKRFPDWEIDRDSAIQARTSTVRGWQSLPVFVP

CYP189A11  Frankia sp. EAN1pec
           YP_001508161.1
           ABW13255.1
           59% to CYP189A7 Mycobacterium marinum
MTTVTTETSDAAGDVYYDPYDFEIDADPYPVWRRMRDSVPLYYNAKYDFFAISRFDDVEKVMGDFETYRS
GRGSVLEIIRSNIDFPPGNILFEDPPVHDIHRSILARVFTPRKMLAIEPKVREFCARSLDSLVAEGNFDF
IADLGAQMPMRTIGMLLGIPEQDQEAIRDAVDEGLTLTEGAPKPLNEDPLARSEGMFADYLDWRARNPSD
DLMTELITAEFEDETGTTRRLTRAEVLTYVNMLSSAGNETTTRLIGWTGKVLSDHPDQLRQVARDRSMVN
QVIEEVLRFEAPSPVQARYVARDVEVHGQTVPEGSVMVLLNGSANRDERQFVNGDSFDIHRSISRHVSFG
RGLHFCLGAALARLEGRVALDEVLKRWDRWEVDYDRAVQARTSTVRGWAKLPVTATPR

CYP189A12  Frankia sp. EAN1pec
           YP_001508322.1
           ABW13416.1
           64% to CYP189A7 Mycobacterium marinum
MPLTSPSDVYYDPYDAQIDADPYPVWRRMRDEASLYYNEKYDFYALSRFEDVEPCLSDWNTYRSGRGSIL
ELIKANIELPSGIILFEDPPIHDIHRSLLARVFTPRKMNALEPKIREFCARSLDPLVGTERFDFIRDLGA
QMPMRTIGFLLGIPESDQEAIRDRLDEGLQLREGEELSVSAEDFNADEFGAYIDWRAEHPSDDLMTELLN
AEFEDETGTVRKLHREEVLTYVTMLAGAGNETTTRLIGWTGKILAENPDQRRELVADRSLIPNAIEELLR
FEAPSPVQARYVARDVEHHGHTVPEGSIMVLLNGSANRDERRFADPDRFDVHRDVGRHLSFGYGIHHCLG
AALARLEGRVALDEVLSRFPTWEIDWDNAVQARTSTVRGWETMPAFVR

CYP189A13  Frankia sp. EAN1pec
           YP_001509005.1
           ABW14099.1
           62% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MSLASHLGDVYYDPYDFRIDADPYPVWRRMRDEAPIYYNEKYEFYALSRFEDVERALSEWGTFLSGRGTL
LEIIKANVPIPSGNILFEDPPVHHAHRGVMARVFTPKKMNAVESKVREFCGRALDPFIGTDGFDFIGDLG
THMAMRTIGYLLGIPEEDQEAIRSLFDDNLRIEDPDNPRPPDIGIDGAFVDYIEWRAEHPSDDLMTELMN
AEFEDETGTVRTLTRDEVIAYINLLAGAGNETTARLVGWVGKLLGEHADQRRELAADRSLIPNAVEEVLR
YEAPSPVQARYIEREVELHGRTIPAGSVVLLLNGSANRDERRFPDPDRFDIHRSVGRHLGFGYGIHHCLG
AALARLEGRVALDEVLQRFPDWEVDWDNAVQARTSTVRGWEKMPVRIG

CYP189A14  Frankia sp. EAN1pec
           YP_001509058.1
           ABW14152.1
           58% to CYP189A7 Mycobacterium marinum
MSRSGPVYWDPFDRDIAGDPYPVYQRLRAEAPLYYNDRQDFYALSRHEDIDRCLTDWKTFSSARGPILEI
IKANVEIPPGTLLMEDPPAHDIHRALLARVFTPRRVTSLEPQVRDFCRRCLDRLVDVDSFDLMAEFANEV
PMRVIGMLLGIPESDQPAIRERADAKLRTEPGQQMKVSQQALMDSDLFAEYIDWRAEHPSDDLMTELLRA
EFEETLRFEPTGHAIARYVTTGVELHGRTVPAGSAMMLLIASANRDENSWSDPDRFDVHRGTGHLRTFGL
GTHYCLGAALARLEARVALEEILKRFPRWNVDWENSALSSTSTMRGWETLPITVG

CYP189A15  Frankia sp. EAN1pec
           YP_001510639.1
           ABW15733.1
           61% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MQDESVYYDPYDFEIDANPYPVWRRLRDSAPLYYNEKYDFYALSRFEDVEKALTDFGTYTSGKGFILEVI
KAGIRLPPGNLLAEDPPLHDIHRGLLSRVFTPRKMAALEPQVRELCARILDELVGTDGFDFVADLGAIVP
MRVIGMMLGIPESDQVAIRDAGTRRHQLTEGEAPAPTDARSTAQPFADYIDWRATHPSDDLMTELLRAEF
EDETGTTRRLTRDEVLTYTSVLAGAGNETTRRLIGWTGQLLGEHPDQCRELAADHSNVPQAIEEILRFES
PSPVQGRVVSRDVEHHGGTIPGTIPEGSAVILLNASANRDERHFADPDTFDIHRRIDRHLAFGHGLHFCL
GASLARMEGRVVLDEVLKRWSSWEVDRDNSVLDHTSTTRGWMNLPVVTS

CYP189A16  Frankia sp. EAN1pec
           YP_001511333.1
           ABW16427.1
           70% to CYP189A4 Mycobacterium smegmatis
MTQDDLYYDPYDVEIDVDPYPTYRRLRDEEPLYYNERLDFWGLSRFADVGAALKDQKRLSSAKGDILEVI
KADPVMPPGVFINEDPPLHTVHRVLVSRAFTPKKMKALEDKIRAFCIACLEPLEGADRFDFVADLGDELP
MRAIGMLVGIPDAEQPTVRDHAQRGLRNERGKPLTVTKDKYFDGDFYADYVAWREKNPSDDLITELLNVE
FEDVSGTTRRLTKEEILIFLAVIAGAGVETTGNLFGWLGKVLAEHPDQRQQIVSDRSLIPNAIEELLRYE
PPGPHVARYVTEDVEYHGQTVPAGSALLLMLSSANRDERQFTDPGRFDIHRSISQHVTFGIGAHFCLGAA
LARMEGRIALDEVLNRFPEWDLDMANARRKPTTTVRGWDSMPAIVG

CYP189B1   Frankia sp. EAN1pec
           YP_001504949.1
           ABW10043.1
           47% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MTEDLYWDPFDREFHVDPHPVWHRMRDEAPVYRNEKMDFYALSRFADVDAAHLDTATYSSAYGTVLELMS
PEPLKTGQIIFMDPPIHTTLRVLVSRAFTPRRVGGLEGHIRQICAELLDRQVGGGGFDYIQDFAALLPSM
VISQLIGVDPADREEIRHTIDQTFHLDPEKGMVNDISMAASAKFHAYLSEQLEARRAAPRDDMMTALVQA
EIATDGGTRQLTTSEAADFTALLVAAGTETVARLLGWACDALEAHPDQRAELAVDPSLLGNAVEETLRYE
SPSPVQGRVTTRDVELHGTTIPARSKIILLTASAGRDGRRYDDPDRFDIRRRVDSHVAFGRGAHFCLGAA
LARMEGRIALEETLRRFPTWEVDRDNAARLHTSTVRGYEKLPIVV

CYP189B2   Frankia sp. EAN1pec
           YP_001504992.1
           ABW10086.1
           49% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MAELYWDPFDEVIDVNPYPLWKRMRDEEPVYRNDKFDFYALSRHADIDAAHVNADTYSSAHGTILEIMKP
EPMPPGFMIFTDAPAHHLLRSLVSRAFTPRRIAALEEHIRVLCAEMLDPQIGAGGFDYISDFAAQLPSKV
ISQLIGVDPADREEVRRTIDLTFHIEEGVGMVNETSHAATIKLRTYFAGLIEDRRRSPRDDMITGLAEAE
VTDGNGERRRLTTPEAASVTNEIVSAGTETVARLLGWACVLLEAHPDQRAELAADPSLLSNAVEETLRYE
APSPVQGRMLKNDVELHGTTIPTGAKVLLLTGSAGRDGRRYTDPDRYDIHRKFDGHVAFGRGAHFCLGAA
LARMEGRIGIEETLRRFPNYQVDHDSAVRLHTSTVRGYEHLPLVV

CYP189B3   Frankia sp. EAN1pec
           YP_001508614.1
           ABW13708.1
           48% to CYP189A4 Mycobacterium smegmatis
MTELSWDPFDKVIHLAPYDVWRRMRDEAPVYRNDRLDFFALSRHADVEAAHRDPATYSSAHGTVLEIMSP
EPMQTGLIIFIDPPTHTELRTLVSRAFTPRRISALEDSIRALCAEMLDPQVGGSGFDYVQDFAAQLPSKV
ISELIGVDPADREDVRQLIDQTFHLEEGAGMINDISFGAQIKLHTYWSEQIELRRRQPRDDMMTALVEAE
VKSETGSRRLTTQEAADFTNLLVSAGTETVARLLGWAGFVLAAHPDQRAEITADPSLIGNTIEELLRYEA
PSPVQGRVLTREVELHGTVLPAKSKVLLLTGSAGRDERKYPDADRFDIHRRFDSHVSFGHGVHFCLGASL
ARLEGRVALQETLHRFPEWDVDHDRAVRLHTSTVRGYEKLPITLG

CYP189B4   Frankia sp. EAN1pec
           YP_001508508.1
           ABW13602.1
           49% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MTDDLYWDPFDKEIDVNPHPLWKRMRDEAPVYHNEKFDFYALSRFTDVDTAHLDPATYSSKYGTVLELMK
SEPWDTGQIIFMDPPTHTTLRVLVSRAFTPRRVGGLEGVIRDLCAELLDPQVGGGGFDFVQDFAAQLPSL
VISQLIGVDPADREDVRKMIDGTFYLDPEKGMFNETAMAATAKFHGYLNGQIQERVKNPRDDMMTALTQA
EITTDDGTRRLSLSEATDFTALLVSAGTETVARLLGWACVLLAAHPDQRADLAADPSLLGGAVEETLRYE
APSPVQGRVTTRDVELHGTEIPAKSKVLLLTGSAGRDDRKYDDPDRYDIRRRFDSHVSFGHGVHFCLGAA
LARMEGRIALEETLRRFPTWDVDHGNTVRLHTSTVRGYEELPIIV

CYP189B5   Frankia sp. EAN1pec
           YP_001510780.1
           ABW15874.1
           47% to CYP189A5 Mycobacterium avium subsp. Paratuberculosis
MPPVTGRARAWRRELAVLGGSQRGPGTEKGSTVTEDLYWDPFDKIIDVNPHPLWRRLRDEAPVYRNEKHD
FYALSRHADVDAAHVEPETYSSAHGTVLELMGPEPFNTGQIIFMDPPTHTLLRVLVSRAFTPRRVGGLEG
SIREICAELLDPQIGGGGFDYVQDFAAQLPSLVISKLIGVDEADREEIRQTIDQTFHIEEGKGMINDVSF
AAQIKLHTYFSEQIDARRTAPRDDMMTGLAEAEITTDEGARRLTTSEAADFTNLLVAAGTETVARLLGWA
GDLLEAHPDQRAELAADPSLLGNAVEETLRYESPSPVQGRVNTREVELHGTTIPAKSRILLLTSSANRDE
RKYPDADRYDIRRNFDSHLAFGRGPHFCLGAALARMEGRIALEETLRRFPNYEVDRDNAVRLHTSTVRGY
EKLPIKV

CYP190A1   Mycobacterium smegmatis
           MSMEG4807 TIGR pksS
           76% to 190A4 Mycobacterium vanbaalenii
           63% to 190A5 Mycobacterium vanbaalenii
           77% to 190A2 Mycobacterium avium subsp. paratuberculosis
           38% to 123A2
MTTPQMIFDPFSEQYFENPFDIYRQMRDDAPLYYDSEQDFYALSRHEDVA 
AALKDHEAFSSSRGCDLAMVKGDEPPQKSIIFMDPPEHRHMRSLLNKAFT 
PRAVQAQRDTVVEQVEHYLGQIDSDEFDVVQDFSGPFPVEVITRMAGVEP 
EYRQQVRHWIDTSLSREPGQVAYSEAGMKANIDTAMYYYSLVQKRRENPQ 
DDMISRLIAAEIPGENGEMRRLDDVEITGFATLLGGAGAETVTKLIGTAM 
VTFAKFPDQWQKLLDDRSKVPAAVEELLRYEGPVQYNVRYTLKEARVPSG 
TIPAGKPVFLLKASANRDERAWTDPDVFDIDRDRTEAQNLGLGYGIHSCL 
GAALARLESTIALERLLDFMPRYEVKWDGLQRVHMQNVAGYSHVPVKVLR

CYP190A2   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017229.1 
           CDS complement(151750..152955)
           Formerly 270A1
MTKPKLVFDPYSEDYFNNPYEIYRRMREEAPLYYDEKEDFYALT
RHVDVAAAFKDYETYSSARGCDLAMVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTP
RAIQSQRETIIEVVDKYLSAADPDNFDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
IDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQDPQDDMISRLIAAEIPGENG
QMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVIFARHPDQWQKLQEDRDKIPGAVE
ELLRYEGPVQYNVRYTLKEAHVSGGVIPAGKPVFLCGAAANRDPEAFTDADTFDIERD
QTEAQHLGLGYGIHSCLGAALARLESRIALERLLDFMPRYDVDWAGCRRVTMQNVAGW
KNVPVKVLR

CYP190A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4733
           69% to 190A2 Mycobacterium avium subsp. paratuberculosis
           38% to CYP123A1
           Formerly 270A2

CYP190A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01205773.1, EAS26765.1 
           78% to 190A2, 76% to 190A1
MTAPELRFDPVSQDYFDNPYEIYRRMRDEAPIYYDAEEDFYALTRHEDVAAALKDHEAFSSARGCDLGMV RSEDGPVKSIIFMDPPEHRHMRSLLNKAFTPRAIQSQRETVIELVEHYLSKVDPDNFDVVQDFSGPFPVE VITRMAGVPEEFRQQVRHWIDKGLERKPGQIEWSDENMQANIDSGVYYYGLVQERRRNPQDDMISRLIAA EIPGENGEMRKLDDIEITGFTSLLGGAGAETVTKLLGSAVVEFARHPEQWQMLLDDRNLIPDAVEELLRY VGPVQYNVRYTVKEAHVPSGTIPAHKPVFLMKAAANRDPRAFDNAETFDITRDRTQAQNLGLGYGIHSCL GAALARTETAIALEHLLDFMPRFEVDFSGLQRVNMQNVAGYHHVPVKVLR

CYP190A5   Mycobacterium vanbaalenii PYR-1 
           ZP_01203858.1, EAS24850.1 
           68% to 190A3  
MAVVDVGRDPVVFDPFSEEFYRDPQGCYPRLRAEAPVYYNATYDFYALSRHADVAAGLKDFATYSSAYGV DLGMVRRGEKVPAKMIISIDPPEHRAMRSLVNKVFTPRAIEALRTMVTDTVTRFLSAVRGDSFDVVQDFS VYFPVDVITQMLGVPEKYRQQVRLWIDESLHREPGQIDMSEAGMQAMAETWLMYYDLIKQRRADPRDDMI SALIAAEVEREDGTVDRLKDSEIAGFATLLGGAGAETVTKLVGSAVVTFARHPEQWQQLLDDRGKIGVAI EELLRYDAPVQYNVRRSNHPVTLHGVTIPAGAPVFLLGASANRDPDAWTAPDVFDINRDRTEAQNLGFGY GIHSCLGAALARLESSIALDMLLDFMPRYGVEWDGCRRVSMQNVSGWANVPVRIL

CYP191A1   Mycobacterium smegmatis
           MSMEG2565 TIGR
           81% to 191A4 Mycobacterium vanbaalenii
           69% to CYP191A3 Mycobacterium marinum
MTTTVKPPVTEAVTGEFSYDPFDPAVMADPTPYYRVLREKYPLYHIEKWD 
TWALSRFSDIWEVLEVNDGTFVASEGTLPAATVLAEHNDGAVPDPPWHPM 
PFHANFDTPIYDSVRRCTSPQFRPRSVTKLADRIRTLANERLDELLPRGQ 
FDLTQDYGGIVAASVVCELVGLPVDLAADVLATVNAGSLAEPGSGVEVAN 
ARPGYLEYLTPVVQRRRAGEGRELPIVDNLLQYRLPDGSAFSDLEAAVQM 
LGVFIGGTETVPKIVAHGLWELTRHPEQLAAVRTDLDANVPIAREEMIRF 
CAPAQWFARTVRKPFTLHGTTLQPGQRVITLLASAGRDEREYPDPDSFIW 
DRRIERLLAFGRGQHFCLGVHLARLEITIMVTEWLKRVGEFRVDERAARR
PPSSFQWGWNNVPVEV

CYP191A2   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017240.1 
           CDS 48827..50038
           formerly 280A1
MDFAYDPFDAEVMANPLPYYRILRDHHPVYYMPQWDTFALSRFD
DIWRVLEVNNGTFVASEGTLPPASVLAQHNDGPVDDPPLHPLPFHAMFDADLYGEIRR
THSRPFRPRAVTDLEGRIRTLANERLDELLARGSFDLTQEYGGVVVATIVCELLGIPT
DLAPQVLAAVNAGSLAEPGVGVDTGQARPNYFEFLLPAVQRRRADPSGPPLEVVDGLL
GYQLPDGSALDDLEVATQMLCIFIGGTETVPKIVAHGLWELSRHPDQLAAVRADPQHN
IPVAREEMIRYCAPAQWFARTVRKPFDIHGQTPNPGQRVITLLASANRDEREYPDPDD
FVWDRPIRRSLAFGRGQHFCIGYHLARLEVAVLLQEWLRRVPDYAIRADAATRLPSSF
QWGWNKIPVEV

CYP191A3   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0399
           81% to 191A2 Mycobacterium avium subsp. paratuberculosis
           29% to CYP123
           formerly 280A2

CYP191A3   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 191A3 M. marinum = ortholog
           formerly 280A2

CYP191A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01206303.1, EAS24065.1 
           31% to 123A1
MVDIPARHRRQRRGPDHVRRAQQQDAGAVAGIGFPGRPGDSGSHADQAGPAGRLHQGTGTPLRAVVGVDG QALARLLHHHLQVQRGDPLLGARRRLGLLRESLPVVEGQPAGRDRHLDERRPRTARRLGGLHPGRPAPVP AAVSAKMSAAQQPDCRPGRRPFTYDPFDPDVMADPLPYYRVLRDEHPVYYLQKWDTYALSRFDDIWNVLE INDGTFVASEGTLPSAAVLAGHNDGPVADPPLHPMPFHANFDAPIYDEVRRCTAAPFRPRNVAKLADRIR VLANERLDELLPRGRFDLTQEYGGIVAASVVCELVGLPADLAPDVLATVNAGSLAQPGSGVEVANARPGY LEYLTPVVARRRAGQGSELPIVDNLLNYRLPDGSALSDTEAAVQMLGVFIGGTETVPKIVAHGLWELSSR PDQLAEVRSDMDANVPVAREEMIRYCAPAQWFARTLRRPFTLHDTTMRPGQRIISLLASANRDEREFPDA DRFVWNRPMPRLLAFGRGQHFCLGAHLARLEIAIMVTEWLKRVPEFRVDTAAAFRPPSSFQWGWSELPVE V

CYP192A1   Caulobacter crescentus CB15
           GenPept AAK24959, C87620
           NC_002696 complete genome 3214816..3216192
           35% to 173A1 40% to BAC45822
  1 MDADVRSAPL IPPAPKVHPR QLGGSFVGEL RIALEMSRNL MGAWCEEDFD NLFTPYVFMG
 61 QPGMVVSDPA AARRILSSPN YVRPVKAARS VRPIAGDGLL LSEGETWRRQ RKSLAPVFTP
121 MAVEGLLPHF VAAGASLAEA LSGHARADLS EAFHHATLDA VLSALFSRRA DAQGDQLAYM
181 VRRYMEGPAH FNLMDFVSRG ADDLTFLDVE RRRQGAAWFQ AVEHLIAQRQ AHPHAEARDL
241 LDRLLAARDE DGAPLSNQEI RDQCGTMLVA GFETTSRLLF WATYLLALDP ATQDRLRAEV
301 LAAPAAAVRT LDDLQAWPLM RSVLFETLRL YPTAPLLARE AIGPDTVMGH AVVPGQIITI
361 SPWLIHRHRK LWDAPTAFVP DRFIDQPHPW GIEAFLPFGA GPRVCIGASF ALAEAQIVLA
421 SLLERFEIGL VSDRPVIPIA SITLGPDHAP AFTLTPVS

CYP193A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC52277    
           NC_004463 complete genome complement(7721594..7723027)
           33% to 104A2
  1 MARGCASRCS RPVSDASPAP RAGTLSGARL ECRLCRFMAL DERCLCVCRC PLLWVMRTRY
 61 RARTPCPNRW GQTAAPERAS LAGHSRETAL STAPRIDIDP AAFWADPYPM LANMRKEAPI
121 AFVPQLGSTL LTSRDDISIS EKQIDVFSSH QPAGLMNRLM GHNMMRKDGE AHQVERRAMF
181 PTVSPKTVKG YWTALFQAHA DRIIDAIEPG RIDFMRDFAL PFSGECLKSI TGLTNIGFAE
241 MDAWSQGMIE GIANYVGDPA VEARCHAATS GIDAAIDDML PVMRKNPDQS ILGVLLASGM
301 PMESVRANVK LAISGGQNEP RKAIAGTVWA LMTHPEQLDL VRRGEVTWLQ AFEEYARWIS
361 PIGMSPRRIA KPWSIRDVAF ELDERVFLMF GSANRDEKHF ERADQFDVRR DTSKSVAFGA
421 GPHFCAGAWA SRAMIADVAL PTLFARAGRI EIADDEPVRI GGWAFRGLQN LPARWLH

CYP194A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC48170        
           NC_004463 complete genome complement(3198120..3199340)
           36% to 176A1
  1 MSDVSEPVAH PPVTDWVNDF DHTDPQWTDD PFPIWDELRA ASPVVHTERF LGCYMPTTYE
 61 AVREIANDTE HFSSRRIIVR DVRPEIARNA APPITSDPPV HKPAKQLLLP PFTPDAMKKL
121 EPRVRTICNE LIDGFISDGK VDAAARYSKY IPVRAIAHML GIPESDSDLF VNWIHMILEL
181 GIKDETMLLQ AVQEMSAYFR THIEERRSRP TDDLISYLMN AKDKEGQPLE ESHVLGSLRL
241 LLIAGIDTTW SAIGSSLWHL ARTPADRERL IAEPGLIPIA VEELLRAYSP VTMAREVVKE
301 TTISGCPVKA GNMVLLSFPA ANRDPKMFPD ADKVVIDRRE NRHAAFGLGI HRCVGSNLAR
361 MEMQVALEEW LKRIPDFRLD PAGTVTWSQG TVRGPRQLPF LLGKAM

CYP194A2   Rhodopseudomonas palustris
           NZ_AAAF01000001 
           complement(3427752..3428951) gene = Rpal3007
           74% TO 194A1
MSERAPVTDWVNDFDHTDPRWTENPYPIWDELRSAGPLVHTDRF
LGCYMPTTFAAVKEISYDTDHFSSRRVIVRNVRSESPPPAPPITSDPPEHKPAKRLLL
PPFTPDAVAKLEPRVRAICNELIDAFIEDEGCDAATAYTKHIPVKTICHMLGIPEDDS
DIFIRWIHEILELGINDDAILMKAVFEMSTYFQGHIAHRKQKPTDDLISTLMNARDDK
GQPLSDAHVLGSLRLLLIAGIDTTWSAIGAALWHLATHPADRERLLAEPELMPTAIEE
FLRAYSPVTMAREVMKETSIAGCPVKPGNMVLLSFPAANRDPSVFPEADRVMIDRKEN
PHVAFGLGIHRCVGSNLARMEMTVAIEEWLKRIASFRLDPSQKVRWSEGTVRGPRSLP
LLFGKPS

CYP194B1    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE12854399 78% to CYP194B2

CYP194B2    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE12855425 52% to CYP194A1

CYP195A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC48121     
           NC_004463 complete genome complement(3142651..3143883)
           34% to 107P2 37% to BAC51802
  1 MNADAKELAA SFDLEKLTPE FYDNPYPTYR ALRENEPVKR LPNGTVFLTR YDDLVTTYKN
 61 TKSFSSDKKR EFAPKYGNTP LYEHHTTSLV FNDPPAHTRV RRLIMGALSP RAIAGMEADL
121 IKLVDGLLDA IAAKGSCELI EDFAASIPIE VIGNLLDVPH DERTPLRDWS LAILGALEPV
181 VSPEAAARGN KAVKDFLSYL ETLVARRRGK PGNPERDVLT RLIQGEGNGE ENGERLTEKE
241 LLHNCIFLLN AGHETTTNLI GNGLVALDRH PDQKQRLIDH PDMIKTAVEE MLRYESSNQL
301 GNRMTTERVE LGGVMLDAGT SVTLCIGAAN RDPAQFPDPE SFDIARTPNR HLAFATGAHQ
361 CAGMALARLE VAIAISRFLA RFPNYAVNGR PVRGGRVRFR GFLSVPCAIG

CYP195A2   Rhodopseudomonas palustris 
           NZ_AAAF01000001 
           305794..307173 gene = Rpal0264
           74% TO 195A1
MSVEEAALAAGPGPPTGRMTCVAPVPAARPDPQISRPFRQRRKS
PIDVKNGNDMETAPAELAEAFDLARLTPDFYDNPYPTYHALRAHQPVKRLASGGYFLT
RYDDLVAVYKNTTLFSSDKKREFTPKYGDSLLFEHHTTSLVFNDPPSHTRVRRLIMGA
LTPRAIAGMEPDLIALVDRLLDAMAAKGRVDLIEDFASAIPIEVIGNLLGVPHDERGP
LRGWSLAILGALEPVIGPEAFALGNAAVAEFLGYLDTLIARRTAEPGDPERDVLTRLI
RGEAGGEKLTAKELLHNCIFLLNAGHETTTNLIGNGLVTLAANPDQKRRLIAEPALIK
TAVEEILRYESSNQLGNRITTAEVEIGGVSMPANTSLTLCIGAANRDPAQFADPDRFD
VSRSPNRHLAFASGPHQCAGMALARLEGAIALSRFLAHFPDYVLDGPPQRGGRVRFRG
YLGVPCRLG

CYP195A3    Burkholderia fungorum
            GenEMBL NZ_AAAJ02000119 
            3110..4828 gene = Bcep1797
            64% to 195A2
MGAAIDVEVGALGDACIGNPDRVGVDDAGVRTARQRNERFVMVG
GKGRGALNDEVHGRRRSDTVEGGRAARAANPAIVTVRRFASPRAIRAKRCCARHPAWR
RAILRRAVHTDESNDASQPPRTPTVACTPSRRAKSGTRTQRHPRRGAPLRRHRMTPAT
ASDASTLARDFDLRHLNPAFHADPYPVYHALRAHEPVKRMPDGSLFLTRFRDVQAVYR
DPKTFSSDKTVEFKPKYGDSPLYAHHTTSLVFNDPPRHTRVRKLIAGALTARAIAAME
PGLVRLVDGLLDAAAARGRIDLIDEFASAIPVEVIGNLLDVPHTERAPLRDWSLAILG
ALEPSLSEAQLERGNRAVSEFIDYLRDLVARRRREPGDPQHDVLTRLIQGEAGGEQLS
EAELLQNCIFILNAGHETTTNLIGNGLVTLTQWPEQRAALLHEPSLIESAVEECLRFE
SSNQLGNRMATVDTEIGGVAVARGTPVTLCIGAANRDPEQFADPDRFDIRRDPNRHLA
FGFGIHQCAGLSLARLEARIAIGRFVQRFPAYRVNGEPTRGGRVRFRGFAAVPVELEP
AGRRTA

CYP195A4   Stigmatella aurantiaca 
           GenEMBL AJ421825 complement(4978..6231)
           66% to 195A2
           note = ORF8
MLRSVSASRPPSPANPVAAFDLARLDDAFYADPFPLYRAMRERD
PVHRMPDGSLFLTRWADLDCIYRDTRTFSSDKRAEFGAKYGDAPLFEHHTTSLVFNDP
PLHTRVRRLIVGALTPRALSTMEPGLRTLVDRLLDGLAVKGAADLIEDFAAAIPIEVI
GNLLDIPTEERGPLRGWSLAILGALEPRLTAEQEACGNEAVTEFLDYLRILVAQRRAR
PGDPATDVLTRLIQGESDGERLTETELLHQCVFLLNAGHETTTNLIGNALELLARFPD
ERARLLRAPALIPTAVEEVLRYESSNQLGNRRVAEDTEIGGVAVPTGTFLTLCIGAAN
RDPARFEDPEHFDVGRQPNRHLAFAGGAHTCAGMNLARIEARIALAAFLARFPDYALT
APPVRARRARFRGFTAMPTRLGSLR

CYP196A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC46159     
           NC_004463 complete genome complement(972593..974053)
           36% to CYP136A1
  1 MLPRSAGAGR NKVAVARCPF GQPTGALVMS MQNVAAPALQ FTAPRRNELT HIPGDEGWPV
 61 IGKTFQVLAD PKGHIEANGA KYGPVYRTHV FGETNVVLLG PEANELVMFD QQKLFSSTHG
121 WNKVLGLLFP RGLMLLDFDE HRLHRKALSV AFKSGPMKSY LSDLDRGISA RVAQWKAKPG
181 EMQLYPAMKQ LTLDLAAASF LGADIGPEVD EINRAFVDMV AAAVAPIRRP LPGTQMARGV
241 AGRKRIVAYF RQQIPLRRGN HGGDDLFSQL CRATHEDGAL LSEQDIIDHM SFLMMAAHDT
301 LTSSLTSFIG ELAANPDWQD RLRAEVLALG LAPGAPSSFD DLEKMPLSEM AFKEALRIKP
361 PVPSMPRRAM RDFTFKGFRI PAGTAVGVNP LYTHHMKDIW PEPDRFDPLR FTEEAQRNRH
421 RFAWVPFGGG AHMCLGLHFA YMQAKCFARH FLQNIEVSLA PGYKPDWQMW PIPKPRDGLK
481 VRVKAV

CYP196A2   Rhodopseudomonas palustris
           NZ_AAAF01000001 
           complement(2360490..2361869) gene = Rpal2059
           70% TO 196A1
MSIQVADSSLVARLSPPKPSALAHVPGDEGWPIIGRTLAVLADP
KGEVEKMARTYGPVYRSRVLGETSITLLGPEANELVLFDNTKLFSSTHGWGPILGRLF
PRGLMMLDFDEHRLHRRTLSVAFKAGPMQSYLAELNAGIAHRVAEWRARPGEMLCYPA
MKQLTLDLAATSFLGTAIGAETEEVNRAFIDMVAASVAPIRKPWPGTAMARGVKGRQR
IVAYFAEQIPIRRAKGGDDLFSQLCRATHDDGALLSNQAIIDHMSFLMMAAHDTLTSS
LTSFVAALAAHPEWQQKLREEIAGLGLKPGEPISFEQLDALPLTEMAFKEAMRLRPPV
PSLPRRATRAFSFKGYTIPAGTMVAVNPLFTHHMPEIWPNPDQFDPLRFTDEASRGRH
RFAWIPYGGGAHMCLGLNFAYMQAKCFAVHLLQHLDLSLPPNYQASWQMWPIPKPKDG
LRVNVAPLN

CYP196A3   Novosphingobium aromaticivorans
           NZ_AAAV01000177 
           complement(59115..60509) gene = Saro3719
           57% TO 196A1 
MASIAPDSRTDLHTERANPHWVRLGGDHKLDHVPGEDGWPVLGT
TLMQLADPLGFQRRMVETHGPVFRTRSFGRRGVNLIGADANELVLFDRDRLFSNEQGW
GPVLNLLFPRGLMLMDFEAHRVDRRALSIAFKPEPMRAYCSVLNTGIAQAVQGWGGQM
RFYDAIKALTLDTAASSFLGLPLGPEADRLNKAFVDMVQASGGVVRRPLPFTRMGKGV
AGRRLMVEYFGRLVRERRADPGQDMFSQFALATREDGSLLPEDVVVDHMIFLMMAAHD
TITSSATVLFWQLARNPDWQDRLRAEARAVTGGDGLPLAYEDLGRMELTEMAFKEALR
FMPPVPNMPRRALRDFEFGGYRIPAGTPVGISPAAVHADPAHWPEPDRFDPLRFTPEN
VSGRHKYAWVPFGGGAHMCLGLHFAYMQVKLLVSHILTRYEVAMQPGPAPSWQAWPIP
KPRDGLRVEMRRIC

CYP197A1   Bacillus halodurans 
           GenPept BAB04298 GenPept NP_241445.1
           34% to CYP174A1 Halobacterium sp. NRC-1
  1 MPTNTMPTGP KGNPVLGNTI EFGKDPLQFI TRCSQEYGEI VRLRFERERD TFLLNDPKHI
 61 QYVFMNKGGE FSKGYQQDPI MGLVFGNGLL TSEGSFWLRQ RRLSQPAFHP KRIADYADTM
121 VGYCERMLNT WMDNDTRDIN DEMMQLTMAI ATKTLFDLDL HKGDTQEASR SLDTVMTAFN
181 EQMTNVFRHV LHLIGLGKLV PPVSRELREA VESLDKMIYS IIEERRKHPG DRGDLLSMLI
241 STYDEDDGSY MTDRQLRDEI ITLFLAGHET TANTLSWAFY LLSQHPHVEE KLYQEVSQVL
301 GNRPATLEDM PKLSYAEHVI KETLRVQPTV WLISRRAEKD VTLGDYHISA GSEIMISQWG
361 MHRNPRYFND PLTFLPERWD NNDNKPSKYV YFPFGGGPRV CIGERFALME ATLIMATIVR
421 EFRMELVDEL PIKMEPSITL RPKHGVTMKL RKR

CYP197B1   Nostoc punctiforme
           NZ_AAAY02000014 GenPept ZP_00110793.1
           complement(44530..45885) gene = Npun5259
           44% TO 197A1
MVADVFELPAPSVNSIVGHLFELGQDPLGFLTRCRDYGDIVPLQ
LGLTPSCLIINPEYIEEVLKNRNDFIKSRGLRALKSLLGEGLLSAEGESWFWQRRLAQ
PVFHQKRINGYSQTMVEYTNRMVQTWHDGETHDIHEDMMRLTLQIVMKCIFSDDIDAG
EAKVVADALDVAMQWFESKRRQNFLVWEWFPRPENIRYRDAIAQMDEAIYKLIQERRN
GGEKTNDLLTMLMEAKDEQTLQQMDDKLLRDEVATLMLAGHETTANTLSWTWMLLAQN
PGVREKLESELNQVLQGKLPTLEDLGQLVYTQQIIKESMRLYPPVPLMGREAAVDTQI
GDYEIPQGMAIMISQWVMHRHPKYFENPEAFQPERWTQEFEKQLPKGVYIPFGDGPRI
CIGKGFAQMEAALLLATIAQRFQIDLVPGYPIVPQPSITLRPENGLKVQLKQIALDTS
K

CYP197C1   Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
           ZP_04000803, ABTX01000013.1  3913-2567
           41% to CYP197A1 Bacillus halodurans (Firmicutes), 
           41% to CYP197B1 Nostoc punctiforme (Cyanobacteria)
  1 MMSSDTPPVT DEMPPGPDGL PVVGNYPSYI REPFEFMTRN AREYGDIVGW EERNGPVYQL
 61 NHPDHIEQVL VQNNQNYVKG DAFQSTLGPI TGSGILNSEG AIWRRNRHLI QPAFHPNRIE
121 EYSEMMTGYT EEMLETWSDG ETREIHEDMM TVTLKIVSRA LFGVDIDDHV EDIGEALESF
181 MEASESLSHY VLPEEIPTPS RKQIQGAREQ LDDVVYELIE DRRANPGEQD VISMLLDVTD
241 DDGNTLSTEQ IRDEVVTLLL AGHETTALSL SFTAYALARH PEAEAKLVEE LDEVLDGRTP
301 TMSDLSELTY TEQVVKESMR LYPPVPGIVR EPVKPDIIGG YEIPAGATVR MHQWVVHRDE
361 RWYDDPLAFE PERWTDDLEQ SIPKLAYFPF AAGPRRCIGD RFAMLEARLL LATIYQKYHL
421 ELTPGTELDL MATVTARPKS EIEMTVERR

CYP198A1   Xanthomonas campestris pv. Campestris str. ATCC 33913
           GenPept AAM42184          
           32% to 174A1
  1 MRRPAFPASV MNSSGAVWQH KRRTLMPAFR AALVRESAMQ ASAATRSLLH ELGDSCATQD
 61 MRTLMTGLCA QLGAGFLLGD SANAADLLRM LPMVDAISKQ TRRQSLAPTW WPSSGRRRLR
121 RLRADIDMAL DRILMQSTQR PPRAASVLAL LLAETARDDG DWCRDEAAAI LMSALEPMSA
181 ALTWTLLLLA QHPHIAQEVA QEASALDGAD VASGTSLLDR LPQSRACVKE SMRLYPPAWI
241 TARIAQRDAT LNGFHVPRGT QLLVSAWVVH RDGRHFPDPE IFLPARWLDD SATHSLTRYS
301 YFPFGGGPRS CIGCMLALTQ MTIVIATVLH ACSLHLAPDA RPSPFPALVL RPMDVRIALR
361 PRVIRSVVPS RAHASPVRLA SVTPND

CYP199A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC46313        
           NC_004463 complete genome 1159976..1161184
           39% to CYP145
  1 MSAPGSAASG VPHLDVDPFD MNFFADPYAA HELLREAGPV VYLDKWNVYG VARYAEVHAV
 61 LNDPATFCSS RGVGLSDFKK ETPWRPPSLI LEADPPAHTR TRAVLSKVLS PTVMKQVRDR
121 FAAAAEERVD ALIEKRSFDA IADLAEAYPL SIFPDALGLK SEGREHLIPY ASVVFNAFGP
181 PNQLRQEAIA RSTPHQAYVA EQCQRENLAP GGFGACIHAQ VDEGAITASE APLLVRSLLS
241 AGLDTTVNGI GAAVYCLARF PEQWQRLRGD LSLARSAFEE AVRFESPVQT FFRTTTREVE
301 LSGATIGEGE KVLMFLAAAN RDPRRWDKPD SYDVTRRSSG HVGFGSGIHM CVGQLVARLE
361 GEVMLTALAR RIAKIEITGE PKRRFNNTLR GLDGLPVTIT PA

CYP199A2   Rhodopseudomonas palustris
           NZ_AAAF01000001 
           3590168..3591556 gene = Rpal3146
           78% TO 199A1
MRPSGLGAAAADRRDFGGRDAPVMGMSAANACADIRTCHGISQV
AIEEDNMTTAPSLVPVTTPSQHGAGVPHLGIDPFALDYFADPYPEQETLREAGPVVYL
DKWNVYGVARYAEVYAVLNDPLTFCSSRGVGLSDFKKEKPWRPPSLILEADPPAHTRT
RAVLSKVLSPATMKRLRDGFAAAADAKIDELLARGGNIDAIADLAEAYPLSVFPDAMG
LKQEGRENLLPYAGLVFNAFGPPNELRQSAIERSAPHQAYVAEQCQRPNLAPGGFGAC
IHAFSDTGEITPEEAPLLVRSLLSAGLDTTVNGIAAAVYCLARFPDEFARLRADPSLA
RNAFEEAVRFESPVQTFFRTTTRDVELAGATIGEGEKVLMFLGSANRDPRRWDDPDRY
DITRKTSGHVGFGSGVHMCVGQLVARLEGEVVLAALARKVAAIEIAGPLKRRFNNTLR
GLESLPIQLTPA

CYP199A3    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha06678
            Submitted to nomenclature committee 12/13/04
            56% to 199A2, 53% to 199A1

CYP200A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC49097        
           NC_004463 complete genome 4251077..4252333
           39% to 107L2
  1 MAPRLDFTSE AFFRDPPAAI AALRASGPVV ATRFPLVGDV WITTTHDATA EVLKDGTTFT
 61 LRKEDGKVAG LRWWMPKLVT TIANNMLTMD EPDHTRLRSI VDEAFRRRAI VAMEPRIRAI
121 ADGLANDLFA DGSPADLVQC YARILPVSVI CELLGLPAAD RPRFIAWANK MSSLTNVVSF
181 FRLLFAFRKM RAYLERQLQI ARVRGGEGLI AELVQVELEG GQITPDEMVS MVFLLLAAGS
241 ETTTHLISGS VYELLRNPAL RDWLEEDWSR ISLAVEEFLR FVSPVQFSKP RYLRRDVELA
301 GVRLKKGDRV MVMLAAANMD PAVHDRPERL DLTRKPNRHM SFGTGIHFCL GHQLARIEAT
361 CALQALLARW PKLELAVDPA QIHWRKRPGM RAIARLPVVA GGNRRPSRGA AAEPLLAD

CYP201A1   Bradyrhizobium japonicum USDA 110
           GenPept BAC45822, NP_767197.1
           NC_004463 complete genome complement(596460..597827)
           35% to 173A1 40% to AAK24959 CYP192A1
  1 MNIASVRRPI VPPTPPRAPD DMSFLGRVAV IRQNMIATWG QRAYEEDVLE GRFFLHKSFI
 61 LNRPDAIRHV LLSNYENYTR TPAGIRMLRP VLGEGLLIAE GHAWTFQRRT LAPAFTPRAT
121 ANLVPHMTAV LDETIAKLDA RSGETVDLRE TMQRMTLEIA GRTMFSFGMD RHGPTLRNFV
181 VEYGERLGRP YFLDMLLPVS WPSPMDFARA RFRKRWTEFV AMLIAERRAA GKKDGAPPRD
241 LFDLMDEARD PETGKGFSDE QLIDEVATMI LAGHETTATA LFWALYLLAL DPDTQEEVAS
301 ETRGEHLDSM ADIDRQKFTR AVIEETMRLY PPAFLIARAA RAKDNAAGIE IGRGDIIMIA
361 PWLLHRHEKL WDQPNAFVPK RFMSTEAPDR FAYLPFGAGP RVCVGAPFAQ AESVLALARL
421 IGAFRVELVD TVPVIPHGVV TTQPDRSPMF RITRR

CYP201A2   Rhodopseudomonas palustris
           NZ_AAAF01000001 GenPept ZP_00010020.1
           complement(1953073..1954536) gene = Rpal1705
           65% TO 201A1
MGSAGAFSLPVSHTTFVEQQRGSGFEVSIAAIDDRPASRAPLIP
PTPPRAPENLSALGRLAAIRHNAIASWGDRAYQDDVVRGRFFAHSSYILNTPDAIRHV
LVDNTDNYRRTATGIRVLRPMLGEGLLLAEGRAWKHQRRTLAPAFTPRAVATLVPHMA
SATDEVVEGLRRKTGVPLDLRETMQHLALEIAGRTMFSFEMGTHGQALRGFVIDYGTR
LASPRFLDLLLPLGWPTPQDVSRALFRRRWTRFIGELIAARRAAGKAEGAPPRDLFEL
MLAARDPETGEAFSDAQLGDQVATMILAGHETTATALFWALYLLALDPDAQERLANEV
RRVGFGGTEIERLPFTRAVLDETLRLYPPAFLIVREAAGPDRVAGFAVRKHDVMLIAP
WLLHRHDKLWSDPNAFVPERFLPGVPSPDRFAYLPFGVGPRVCIGAHFALVEATLALA
KIVGTFRIELIDTEPVIPIGVVTTQPDRSPLFRLTPR

CYP201A3    Magnetospirillum magnetotacticum
            GenEMBL NZ_AAAP01000877 
            60% to 201A2 runs off the end
675 LILAGHETTAV 643
640 PLLWACTLLALSPETQERVAAESGQADKPFTRAVIDETVRLYPPAFVLARR 488
487 AAGVDTLGGETVQPGDSVTISPWLLHRHRRLWRDPDAFDPGRFLPGASPVPRFAYLPF 314
313 GAGPRVCIGAAFALTEATLALSRIVGRFRLARADARPVLP 194
    AAVVTTQPDHAPAFRLTLRT* 131

CYP202A1   Sinorhizobium meliloti
           GenPept CAC45831                 
           40% to 107P1 56% to 202A2 NP_108561
  1 MSIAPGITID GPARRVSLDV RNPRFFRNPL PAYAALHAQC PAFFWEEPQQ WFFAGYEQVN
 61 SLLRDRRFGR QILHVATREE LGMPEPKPHL KDFDALEAHS LLELEPPAHT RLRTLVNRAF
121 VSRQIEELRP EIEALSHAVI DGFEKDGETE LLKTYAETIP VTIIARMLGI PVEAAPRLLD
181 WSHRMVKMYV FNPSLETEFD ANNASAEFAD YLKGIIAEKR TNPADDLLTH MITSEKDGER
241 LSDAELISTT VLLLNAGHEA TVHQIGNAVR TILQSGLSPA ELFSDEKATE RTVEECLRFA
301 APLHIFQRYA LMDIELENGI ALRKGDKIGL MLGAANVDPR KFSSPDTFRP DRNEGANVSF
361 GAGLHFCIGA PLARLELQIS LPILFRRLPG MRLKNEPPVK DAFHFHGLER LDLVW

CYP202A2   Mesorhizobium loti
           GenPept NP_108561                
           42% to 107P2 56% to 202A1
  1 MTNSTLPYLA FDPATRRLRL DPHEPAFFLN PYEAYGFLHD VSNAFFWEEF GFWCFGGFDD
 61 VNRLLRDRRF GRQNPAGIPD SRGVGQDRSH LRAFDGIEAN SMLELEPPVH TRLRTLVNRA
121 FVSRQVERLR PRVEALANEL IDRFDPTGPV DLLPAFASPL PITIIAEMLG VPVEMGPQLL
181 DWSHQMVAMY IHGRTRETEE TANRAASEFA DFLRGYVAER RRNPGDDLLS LLISAQEDGE
241 RLSEDEMVSS AILLLNAGHE ATVHQTGNAV RSILAQGGDP SRFFTSAEAT AATVEECLRF
301 DAPLHMFMRY AYQEIEIAPG IVVRPGQTIG LLLGMANHDP RAFAEPQAFR PDRADQKNVS
361 FGAGIHFCIG APLARLELQV SLKTLFERHP RLHLAEQSRF RDTYHFHGLE TLAVGF

CYP202A3   Agrobacterium tumefaciens strain C58
           GenEMBL NC_003062 complement(1243027..1244274)
           63% TO 202A1
           locus_tag = AGR_C_2319
MTATFPFLKIDPATRRVSLNARDPAFYNDPNPVYAALHAQCPTF
YWEEQRQWFFTCYDHVSTLLRDRRFGRQILHVASREEIGLPEPLEHVKHFDLAEQHSL
LELEPPEHTRLRTLINRAFVSRHVDKMKPEIEELANRLIEAFEANGETELLSSYADII
PVTMIARMIGIPEEMGPQLLKWSHAYVGMYMFKRTPEDELLADKAAQEFSDYVRRVIA
ERRAEPKDDLLSHMIHTEHKGQYLTDDELVSTTIVLLNAGHEATVHQIGNSVRIILES
GLDPKTLFHDETATERTVEETLRICAPVHIFQRWVLEPVEIDGVQFKRGDKVSLILAA
ANLDPAKFSDPLAFQPDRNEGANVSFGAGIHFCIGAPLARLELNLALPLLFKRLPGLK
IAEPPKVKDVYHFHGLERLDLAW

CYP202B1    Rhodobacter sphaeroides
            GenEMBL NZ_AAAE01000131 
            30501..31682 gene = Rsph2231
            48% to 202A2
MQTLSQSPHDRRFLRNPYRFYREARAAGPFFHWEELGLVCTTSY
AAANAILRDRRFGREVPPGRASAVPDHLAPFAAVEAHSMLELEPPRHTRLRNLVLRAF
TSRRIGTMQPEVAALSESLVAAVPEGPFDLLPAFSQRLPITLIARLIGIPESLAPELL
RWSSAMVAMYQAGRTRKTEERAALAAADFSDFLRLHIEARRHAPADDLLTHLIAAEAD
GQQLSTDEIVSTCILILNAGHEAAVHAIGNAAAVLLRHRTPPEALAPPHLLGTVEELL
RFDPPLHLFRRMAYERVEIMGRTIEEGCEVALLLGAANRDPGPWERPDRFLWNRPEKT
HLAFGAGLHFCLGAPLARLELATALPILFGRLPNLQLVKPPSYGDSWHFRGLERLIVSA

CYP203A1   Rhodopseudomonas palustris
           NZ_AAAF01000001 
           2600909..2602096 gene = Rpal2284
           35% TO 113B1
MFSFDPYSPIVDADPFPLYKTLRDEYPVFWSEPAQMWILSRYLD
VAGAGSNWQVFSSAKGNLMTELPNRAGATLGTTDPPRHDRLRGLVQHAFMKRNLEALA
EPMREIARDAAEALRGRDQFDFISDFSSKFTVRVLFAALGLPMGDEQTVRDKAVLMVQ
SDPVTRAKGPEHLAAYAWMQDYASSVIAQRRAEPKNDLISHFSMAEIDGDRLDEREVL
LTTTTLIMAGIESLGGFMSMLALNLADFADARRAVVADPALLPDAVEESLRYNTSAQR
FKRCLQSDLTLHGVTMKAGDFVCLAYGSANRDERQFPNPDVYDVKRKPKGHLGFGGGV
HACLGSAIARMAIRIAFDEFHKVVPDYTRTEQQLNWMPSSTFRSPLRLDFAVEQAASR
SAA

CYP203A2    Novosphingobium aromaticivorans
            GenEMBL NZ_AAAV01000114
            complement(9289..10479) gene = Saro1156
            62% to 203A1
MATVIERPQFRFDPYSPAIDADPFPAYKVLRDEYPCFWSEEAGK
WVLSRYDDVLAALQDWRTYSSAKGNLVDEFPGRAGSTLGSSDPPRHDRLRALIQSAVT
KRALEHIIAPARASAQAHLAALADKPVFDLVGDYTSKLTVDLLFYLFALPDEGAQQVR
ENAVLMVQTDPVTRQKSPEHLAAFHWMADYAEKLVASRKANPGDDLLSSFITAEIDGE
KLLDKEVQLTVTTLIMAGIESLSGFMAMFGLNLADYPEARSALVADPSLIPDAIEESL
RFNTSAQRFKRTLTRDVELHGQVMKAGDAVILAYGSANRDERMFENPDVYDITRKPRR
HLGFGGGVHACLGSMIGRLATQIAYEELLKAVPDFRRADAPLDWVPSSNFRSPKSLML
EKKA

CYP204A1   Novosphingobium aromaticivorans
           NZ_AAAV01000167 GenPept ZP_00095854.1
           16299-17720 gene = Saro2888
           30% to CYP51A2 in Arabidopsis 27% to CYP51 M. tuberculosis
MARAATAAGNGLPLLDGGVPLLGHLAQFFRDPVSVLKRGYRSKG
RLFAMNFMGQRMNVMLGPEHNRFFFEETDKLLSIRESMPFFLKMFSPEFYSFAEMDEY
LRQRSIIMPRFKAASMKQYVPVMVEESLNLVERLGEEGEFDLIPTLGPVVMDIAAHSF
MGREFHEKLGHEFFELFRDFSGGMEFVLPLWLPTPKMVKSQRAKRKLHAILQSWIDKR
RAAPLDPPDFFQTMIETKYPDGRPVPDEIIRHLILLLVWAGHETTAGQVSWALADLLQ
NPDYQKVLRGEISSLLGGSDGRDLGWEQAVAMEKMDLALRETERLHPVAYMLSRKARA
DIERDGYVIRKGEFVLLAPSVSHRMEETFRNPDAYDPERFNPANPDAQIESNSLIGFG
GGVHRCAGVNFARMEMKVLVAILLQNFDMELMDEVRPIAGASTYWPAQPCRVRYRRRK
LDGSEAGADMAALARAAGCPAHT

CYP204B1    Saccharopolyspora erythraea NRRL23338
            SACE_3928, se: 4309034,4310356 (-) STRAND, 
            47% to CYP204A1, 30% to CYP51B1 Msmeg
MLSGARPLVGHAGEFIRNPVAMAERGYAECGEAFSVRIPGWTAHMFIGPEHNRFFFSETD
RRLSIRTAYPFFVRMFDPAFYFFAGDDEYRRQRALVLPRFQGRQLENYVATMVDEVCELD
RALGNSGEFDLVRTMGPLVMRIAARAFLGREFSARLENGFFEKFRRFSAGMDPVMAGWLP
LPHLVRSRFAKRELHRLMGELIRQRRRSPVEPGDFLQTLIEARYDDGEVVPDRVLINLIL
LFSWAGHETTTGHISWAVIDLLRNPEALRKVLEETHGVLGSRSFGELTLSDVGKLKYLGH
ALHETERLHPVAFTMARTAAEAFEYAGYRIPEGAMLMISPAVTHRLPGLYPEPDRFRPER
FQDNPKDTRYLVGFGGGVHRCLGVHFAYLEMTIALAHLFREFEFELLDTNPRPVPGAHTK
WPRSPCRVRYVRRAGTGRAA 

CYP205A1   Chloroflexus aurantiacus
           NZ_AAAH01000322 GenPept ZP_00019057.1
           1835..3214 gene="Chlo2055"
           41% to 197A1 and 197B1
MIPAIPVLIGDTAMIRFPSPVAIRNLQQLRREPLTLLEELAARG
DVVPFRVGPQMMVLVNHPDLIREVLVTQHRSFVKGRVLERAKRLLGEGLLTSEGELHL
RQRRLMQPAFHRQRIAAYGDAMVAVAEARSARWQDGLVLDVSREFMAITLQIVGITLF
SADTEADADEVFAAMHDLVAMFDLAVLPFADWLFALPLPPVRRFQAVKARLDAIIYRL
IAQRRANPVDRGDLLSMLLTAVDHEGDGYRMTDTQLRDELLTIFLAGHETTANALTWA
LYLLAQYPSLAAHLAAELDTVLGGRKPTVADLPKLTYTSWFFAEALRLYPPAWLIGRR
AIAPVTLGDVRIAPDTIVLLSPWLMHHDPRFFHEPYHCDPLRHTPEAQAQRPKFAFFP
FGGGPRTCIGEPFAWMEGILVLATLAQRWQFLPVADHPVVLQTGITLRPRYGMQLQLR
ERRTVLGAA

CYP205B1   Frankia sp. CcI3
           YP_483539.1
           ABD13810.1
           not like alni P450s same as ABD13810
           52% to CYP205B2 YP_001509421 EAN1pec
           45% to CYP205A1 Chloroflexus aurantiacus
MSRAPHVRSVAAPPSTAKTSDIKTSDRVPGSGEGPVEAIRRLRADPLTRLNELARAHGPVVRLASWPVSA
FLVTDPDAIADALVSGHRAYAKGAVRRGAGSRRTVVQPLALLLGQGLLTSAGDTHRQQRRLLQPLFHKQR
IAGYADAFAAIADKTADGWRDGQRLDVHTEMTEMTLAIVARTLFDVDLDSHVVDVIRAALDQNMPAARRA
QLPGFTTLERLPLPAPRRRRDARNALDRVVHDLIADRRATGATGNDLLSLLLTARDADTGASMDDSQVRD
EALTLLLAGHETTANALTWTFHLLGRDPEVLATLQAELDRVLGERRPTIDDLPQLPYTNAVISEAMRLYP
PVWAMGRHLVEDRDVAGYRLPAGSTLVFSQWVVHRDERWWPRPELFDPIRWTGPDTADEPADAGPKMRPR
FAYFPFGAGPRQCIGNTFAITEGVLALAAIARRWSFTPVPGLPVTPQPLVTLRPKDGLPMIAHGRYPNR

CYP205B2   Frankia sp. EAN1pec
           YP_001509421.1
           ABW14515.1
           42% to CYP205A1 Chloroflexus aurantiacus
MSIDRLPTAGHTGAQAPGPGRATPAFLRELLADPLRLFTRLRTSYGPIVRVPVGRGGFHLVCGPEAVEQV
LVGEQRAYAKGLRRRTMPPGEGIQPLSLLLGSGLLTSGGDLHRTRRRLIQPMFHRERIAGYGAAISELSR
ATALGWADGSRREVHTDMSELTLAIVARTVFGVDVDSEVVRRVRRAVAANMRLSQLAVLPGAIRLQQHLP
IGPLRAARDARDDLTAVVMEMIEQRRSLDAAGSDLLSTLLATRDADTGAPLDDTSIRDEALTILLAGHET
TANAMAWAYHLLATNPQARDRMHTELDDVLNGRKPTTADLAELPYTRAVFSETLRLYPPAWILLRRTTRD
VTLTGYHLPADTNVLLSQWVIHRDPTWWPAPEEFRPQRWLTPDPTRPKYAYFPFGGGTRQCIGNTFAEME
GALALAAISSIRTLTPTPGRPVTPIPRVTLRPQPLQMTAHPRTPHPTPATHQPH

CYP206A1   Agrobacterium tumefaciens (strain C58, Cereon)
           GenPept H97549
           NC_003062 1555403..1556797
           34% to CYP173A1
  1 MTEIGFRTPS TDTTGAQPVS KLATARLALS LIRNPLKALP PEIFSEPAVF TRLGGVMRVH
 61 LADPVLIHEA LVKNAALLGK GEDVRRALGP ALGQGLLTAD GDHWKWQRQS VAAAFRHEKL
121 LELLPVMIET ARRTQKRWRS SSTADIDIGH EMMRTTFDII VETMMSGGYG IDIARVEQSI
181 TDYLKPTGWT FALAMLGAPE WLPHPGRRKS RAAVDYLRAS LATVITGRRK NPTDRPDLVS
241 MLLEAKDPET GRMMSDEEII DNLLTFITAG HETTALGLAW TFHLLSQNPE TERKAVEEIE
301 AVTGGEPVAA EHIANLAYVR QVFSEAMRLY PPAPVITRTA LQDFRLGEHD IPAGTVLYVP
361 IYAVHRHTAL WDEPERFDPS RFEPEKVKAR HRYAYMPFGA GPRVCIGNAF AMMEAVAILA
421 VILQKNHLEN RTMASAEPLM RVTLRPQERL MMKITQRQNK SPAV

CYP207A1   Kitasatospora griseola
           GenPept BAB39208  
           GenEMBL AB048795 6250..7698
           30% to 183A1
  1 MKGNLPAMST ATSSSVTGSV TTPRTATTPG RRPGLAPGGV PVLGHLPMIL RSRFEFIETV
 61 RNAGPVTRVK LGPKTAYFVN DYELLAQILV SDADKFVRGI HFKKMRNMVG NGVVTTSGDL
121 HRRQRRIMLP SFSQRRLAMH LPVMRKIMSE FVASVPERRP YDLMGPVMGV GCDIVTSTML
181 GEKTPPEVLR LVREAVPVFV ENAAIQAVDV TGIYKHLPTK SNRDFERLLN AFNEYMYSVI
241 DDKFRNGAGE EAGLLDMLIN ATDPETGEKF DRTEVRDQAA TILLASTETT ANTISWACYE
301 LARHPRIFAE CRAEIDALVK DRDWLDIEIG RHDLPALKRV LFEALRMYPS SYLLSRQASV
361 DTTLGGYAIP KDAAILYSHY GQQRDERNFP HGDEFDPDRW LDKDGAEVTA SAFMPFGFGA
421 YRCLGESVAV LEATYCLAMM VHQWDFALSD YSEPKMNATI TLSPKDLEFL FTKRTESGAH
481 DE

CYP208A1   Streptomyces globisporus
           GenPept AAL06697  
           38% to 184A1 
  1 MRIDPPGPPL RALPGLLRKL AVDRLGMMRD AAGLGDAVRV SMGPKKLYIF NRPDYAKHVL
 61 ADNSDNYHKG IGLVQSRRVL GDGLLTSDGE TWREQRRIVQ PAFKPGRINQ QAAAVAEEAA
121 KLVALLRGHE GGGPVDVLQE VTGLTLGVLG RTLLDSNLTA HESLAHSFEE VQDQAMLEMV
181 SQGTVPAWLP LPPQARFRRA RRELYRVADL LVADRRSRMA DGGPGDDALS RIIVAADRRR
241 DDPARARNRL REELVTLLLA GHETTASTLG WTLHLLERHP EVRDRVRAEA RAALGDGVPG
301 PEDLHRLTYT TMVVQEAMRL FPPVWILPRV AQQRDVVGGY TVSAGSDVLV CPYIMHRHPG
361 LWEDPERFDP ERFEPRQTAD RPRYAYIPFG AGPRFCVGSN LGMMEAVFVT ALVTRDLDLR
421 TVAGHRAVAE PMLSLRMRGG LPMTVSTAR

CYP208A2    Streptomyces carzinostaticus subsp. neocarzinostaticus
            GenEMBL AY117439 
            complement(50199..51551) 
            70% to 208A1
MNGRRPVSPPLRALPGLLRKLAVDRLGMMRDAAALDDAVLVSMG
PKKLFVFNRPDYAKHVLADNAANYRKGIGLIESRKMLGDGLLTSEGELWREQRRTVQP
AFRPARVAAQADAVAEETMNLRDLLMRRGADGPVDVLQEVTGFTLGVLGRTVLNTDLG
GYGGIAHAFEAVQDQAMFDMVTQNMVPTWAPLATQRRFRRARRELIRTVDELVADRSA
RMTDGEEADDAFSLMIAAARRQTDPRTGQGRLRDELVTLLLAGHETTASTLAWTLLLL
ARHPHMRDLVREEARGVLADGRAPDAGDLRKLTYTTQVVQEAMRLYPPVWILPRVARQ
SDEVGPYSVSAGADVLICPYTLHRHPDLWERPEQFDPGRFDPARVADRPRYAYIPFGA
GPRFCVGSNLGMMEAVFVTALLTRDLVLEVVPGDERTPEPMMSLRMRGGLPMTVRPVR

CYP208A3   Actinomadura madurae 
           GenEMBL AY271660 10415..>11426
           maduropeptin biosynthesis gene cluster
           partial sequence RUNS OFF END
           69% TO 208A1
           gene = madE7
MSIDELDARGGTPRAAGRVPPGPPRRATPNLLRMLATDRLGMMQ
AALRHGDAVRVGLGPKALYLFNRPEHAKHVLADNSGNYHKGIGLVQARRALGDGLLTS
EGDLWREQRRVVQPAFQHKRIAGLADAVVEEAGALVARLRARAGGPPVDVVGEMTALT
LGVLGRTLLDADLTAHTSLGRAFETVQDQAMFEMVSQGMVPMWLPLPGQLRFRRARRE
LDRIVRALVAERLREGGGAEDALSRLIESARREPDGRVGRRRLRDELVTLLLAGHETT
ASTLGWTFHLLDRHPLVRARVRAEARAVFGDGTPTLDDLSALSYTTMVVQEVMRMYPPVWI

CYP208A4    Salinispora tropica (marine actinomycete)
            Strop_2694 complement(3029601..3030959)
            62% to CYP208A1 Streptomyces globisporus
            67% to CYP208A3 Actinomadura madurae
MTVAAAGRTFSGPTGAALLRSLWQLGQDRLGLMTSAARYGDAVRLGVGSRSLYFFNHPDH
AKHVLADNSGNYTKGLGLVHARRALGDGLLTSEGELWREQRRVIQPVFQAKRVAGQAHAV
AEEADRLIARLRARRGRGPVNLTDEFTALTLGVLGRTLLDANLDAFTTVGAAFEEMQNQA
MFEMASMSMVPMWVPLPQQLRFRRARRELERIVGRLVADRTARGEGTGADDALSRLIAST
RDEPDPGVARRRMRDELVTLLLAGHETTASTLGWTFHLINQDPRVRVRLREEAIDVLGGR
LPEYADLARLTYTKMVVSEAMRLYPPVWMLSRLARDADVVDGYPVPARADVLICPYTLHR
HPAFWPEPERFDPERFDPEVTTDRPRYAYVPFGAGPRFCVGNHLGLMEAVFVVAMVSREF
DLVAPVGQPVVAEPMLSLRVRGGLSMTVEPVS

CYP208A5    Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR611
            84% to CYP208A1

CYP209A1   Myxococcus xanthus
           GenPept CAB40542 
           38% to 110D2
  1 MGTSEPVEPD HALSKPPPVA PVGAQALPRG PAMPGIAQLM MLFLRPTEFL DRCAARYGDT
 61 FTLKIPGTPP FIQTSDPALI EVIFKGDPDL FLGGKANNGL KPVVGENSLL VLDGKRHRRD
121 RKLIMPTFLG ERMHAYGSVI RDIVNAALDR WPVGKPFAVH EETQQIMLEV ILRVIFGLED
181 ARTIAQFRHH VHQVLKLALF LFPNGEGKPA AEGFARAVGK AFPSLDVFAS LKAIDDIIYQ
241 EIQDRRSQDI SGRQDVLSLM MQSHYDDGSV MTPQELRDEL MTLLMAGHET SATIAAWCVY
301 HLCRHPDAMG KLREEIAAHT VDGVLPLAKI NELKFLDAVV KETMRITPVF SLVARVLKEP
361 QTIGGTTYPA NVVLSPNIYG THHRADLWGD PKVFRPERFL EERVNPFHYF PFGGGIRKCI
421 GTSFAYYEMK IFVSETVRRM RFDTRPGYHA KVVRRSNTLA PSQGVPIIVE SRLPS

CYP210A1   Polyangium cellulosum = Sorangium cellulosum
           GenPept CAD43453  
           spiL biosynthesis of spirangiene
           40% to 110E2
  1 MISISKSKQK LLPPGPRSPM ALQTLQWLKN PVPFLEACGA RYGEMFTLKL PTQWPVVVVQ
 61 HPEAVKEVFA LDSNAGHAGE ANNILKPFLG KYSLLVLDGE EHMRQRKMMM PAFHGERMEA
121 YGHAMIDAAH ASIDAWPVGS PFGVHAPMQA ITLQVILRTV VGMTDGPLLA ELEALYPQVI
181 DAASAPAMHF ELFRKDLGPW SPWGKFKRRS ARGKEIMIHE IRRAREKGTA GRTDVLAMII
241 DAKDENGELL TEDEIHGELM TLLVAGHETT ATALCWALRW LLRDAALTRR VAEEAAEVAD
301 DPVKIAKSEL LDRVVKEALR LQPIGPVVAR VLKQPLTIQG RELPADVMVA PCVQLLHHRP
361 SLYPEPTRFD PDRYATFTPK PWEFIPFGGG LRKCIGAAFS MYEMKMVLAT AFSRLSMELA
421 TDDIKIIRRG VTLAPSGGLP LVIRKKSPRA TKPIAA

CYP211A1    Streptomyces globisporus
            GenEMBL AY048670 
            47223..48479 ORF29
            39% to 107L1
MAGLVMSPVEALDALGTVQGRQDPYPFYEAIRAHGQAVPTKPGR
FVVVGHDACDRALREPALRVQDARSYDVVFPSWRSHSSVRGFTSSMLYSNPPDHGRLR
QVVSFAFTPPKVRRMHGVIEDMTDRLLDRMARLGSGGSPVDLIAEFAARLPVAVISEM
IGFPAKDQVWFRDMASRVAVATDGFTDPGALTGADAAMDEMSAYFDDLLDRRRRTPAD
DLVTLLAEAHDGSPGRLDHDELMGTMMVLLTAGFETTSFLIGHGAMIALEQRAHAARL
RAEPDFADGYVEEILRFEPPVHVTSRWAAEDLDLLGLSVPAGSKLVLILAAANRDPGR
YPEPGRFDPDRYAPRPGGPEATRPLSFGAGGHFCLGAPLARLEARIALPRLLRRFPDL
AVSEPPVYRDRWVVRGLETFPVTLGS

CYP211B1    Salinispora tropica (marine actinomycete)
            Strop_1867 2135609..2136880, 
            45% to CYP211A1 Streptomyces globisporus, 
            45% to CYP107AE1 Streptomyces sp.
            44% to 107L2, 45% to CYP107AZ1, 42% to Strop_2480
            note CYP211 is quite close to CYP107
MDASEAVALLMSPLGRIDPYPTYERLRAHGPVVQTAAGFFVVTGYTEADTVLRNARLAFE
VMDDELRDDVFPHWQDSPAMKSIARSMIRANPPNHGRMRRLAAGAFTPRRIAALREVVTA
QADELADEMIRAGRDGAPVDFMGSFAYPLPVAVICALLGVPAADWARFRGWASDLTAVLE
PEITPQELTVADAGASELRDYFTELIAQRRRAPADDLTTALVQTHDADGDRLSGEELLAN
LVLLLVAGFETTTNLLGNGLVVLLAHPDSATALRDQPELAPGHVDELLRYDSPVQLTTRT
VRESVLLAGVELPAGSWVLVLLGAANRDPERFTDPTRFDPGRAQSPPLSFGAGAHYCLGA
GLARLEAQVAFPLLLRRLPELALAGEPTRRNRLTLRGYETLPVTVSAIAADHGTPAGVAR
GTP

CYP211C1    Salinispora tropica (marine actinomycete)
            Strop_2480 	complement(2788560..2789786)
            41% to CYP211A1 Streptomyces globisporus
            39% to CYP107L1 AF087022  Streptomyces venezuelae
            42% to CYP211B1 
            note CYP211 is quite close to CYP107
MLDVEGLLTRLYSEQGRQDPYPVYAGLHAQGAIAALAPRPEGQRVAAVAVGYDLVGAVLR
DPEWSKQPPPGWMEQEILRTLQSSMMFINPPDHGRMRKVFAGTFTPRRLGTLEPVINRVA
DELLDRMADAGPGEVDFVAEFAYPLPARVMAEFIGIPATELAWYRDRVDRIDAFLDVAGK
TPERLAAANAAAAELRVFYADLLARRRRTPGEDLISGLVEAVDAGGVQLTEDELINNLIV
LFNASFVTTVYMLSNGLPVLLEHPEVAAALADDPELTAGAIDEILRLQTPVHLLARAAPR
DTVLGGVPIPQGQNVLLLIAAANRDPAHFPDPDRFDPRRPGPPSLAFGLGLHYCLGAAVS
RLEGRLALPRLLSRFPRLRIMEQPVYSGSLFLRGIDKLSVSPGGRMHP

CYP211D1    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE2708 46% to CYP211B1

CYP211E1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY1166 40% to CYP211A1
            Formerly CYP211D1 but not orthologous

CYP212A1    Chromobacterium violaceum ATCC 12472
            GenEMBL AE016919 complement(139513..140919)
            NC_005085 complement(2867614..2869020) 
            locus_tag = CV2656
            57% to 2A12A2 33% to 205A1
MKTPPQSSCPFHAVGRPPTPPRSSAGRWPPGPESGLTGWGLLKL
MSRDLMGTLAGWQREFGDLVHVRTWPEHQVIVSDPQLARELLVNQADALQRWERALTV
YRRVHGHSVLIAEGQVWREKRQALQPDFTRKSVQAFSPSIVEAARRAFEQWPARHAAW
PIESELTSVTMEVILRMMFSSGVGSEAQQAEEAVHTLMVASTEELWRPASLPDWVPWQ
RKRRRARLLMNGLIERHLQARLAMPQDAWPEDLLSRLLRLHLQQPQSWPLQAVRDECK
TAFLAGHETVATSLTWWAWCMASHPEIQERAREEALAALSGGGQADPAALQYVSQTLL
ETMRLYPAVPLLMSRRALKPVTLGDWTFPAKTVFMVPMQLMQHDERWFPEPRSYRPER
FGPDAARPQQGAYLPFGGGPRVCLGQHLAMAEMALVAAQLLLRYRLSAPEGAEPPRPV
FHVSQRPSQPLTLGIARI

CYP212A2    Ralstonia metallidurans
            GenEMBL NZ_AAAI01000313 
            14554..16035 gene = Reut2995
            57% to 2A12A1 32% to 197B1
MTVDVVSIQDSPRGSVWNLHMTTESQAQCPFQTAKSPPPAGSPL
PHPYGTWPPGPAAGLTGWHLLRRMSRDLLGTLGEWQQTYGDVVHLRMWPEHAVVVTDP
QLVRELLVTHHDSLIRWERGTRVFSRVHGHSVLTAEGDAWSRKRQALQPGFMPKAVHG
FVPGIVEIVDKGLATWPTRVADWPVESALTSLTMDVIVRMMFSDEIGEDARVAECAVR
AISEAANADFYWPASLPDWVPWKRARRRALHTLRDLIERHLQARLRMRTDTWPDDLLS
RLLCLHRDDATAWPLQAVRDECMTTFLAGHETTAATLTWWAWCMASNPSAQDAARAEV
THVLRGQAPTADSRQALRQVVQTITESMRLYPVAPVLISRRAVRPITLGPWRLPARTL
FMLPLQLMHHDPRLFPEPERFQPDRFSTGSPQAPRGAYMPFGTGPRVCLGQHLATAEM
TVIAAMLLQRYKLSVPEGAAHPRPLLNVTLRPDQPLWLAVTPI

CYP213A1    Synechococcus sp. WH 8102
            GenEMBL AABA02000001 or GenEMBL BX569692 335184..336428
            63% to 213A2 31% to 120A1
1370816 MTAAPLPSTGAVTGLGETLAFFRDPSFSQRRFSELGDVFETKLLAQSIV
        FIRGERAIGDLLKQEDCLQGWWPDS
1381038 VRQLLGSKSLANRSGADHKARRRVVGQLFSSAALS
        RYTPAIEALVNDLANELQQAEGPIPLAARMRRFAFSVIA
        TTVLGLEAENRDALFADFEIWTRALFSIPLALP 1381358
1381359 GTPFARALAARQRLLARLKTVLQTNNNRQQGGLDLLSGGLDEAGLPLDDDDLVEQ 1381523
1381524 LLLLLFAGYETTASSLSCLFRALLLNPEVEQWLMQDLNNHERPSRLDATVL 1381676
1381677 EVMRMTPPVGGFFRQNTQSIELADVAIPQGRVIQVVLSSSSTTNQIDLETFRPQRHL 1381847
1381848 DGSFQQTLLPFGGGERVCLGKALAELEIRLMAMGLLQRVQLHL 1381976
        EPDQDLNLQLIPSPTPRDGLLVRATAR* 1382160

CYP213A2    Prochlorococcus marinus str. MIT 9313
            GenEMBL AAAZ02000001 
            63% to 213A1 35% to 120A1
1661568 MASSDDAKLRPLPNTAALSGVLEAFAFFRDPAFAQKRFERHGNVFETSLLGQPMVFIQGGQAIRDLLA 1661771
1661772 QPNAVEGWWPESVRQLLGSHSLANRNGASHRARRRVIGQLFSASALQRYSAGIISMVQ 1661945
1661946 DLADELQAAKTALPLAERMRRFAFSVIATTVLGLEGTDRDELFVDFEIWT 1662095
1662096 RALFSIPIALPGSSFAKALKARERLLRRLQKVLLKASNGNGGLDLLAGGLDE 1662251
1662252 AGIPLTDEDMVEQLLLLLFAGYETTASSLSCLMRELLLNPQVETWLREEINGVDWPPAPE 1662431
1662432 QATTAYDQVNAPKLDAVVSEVMRLTPAVGGFFRRTKCALVIDGVEVPKNRVVQVALA 1662602
1662603 ASNRHGAGDLEAFRPQRHLEDGCSATLLPFGGGERVCLGKPLAELEIRLMVVGLFHQLR 1662779
1662780 LHLIPDQDLTLQMLPSPTPRDGLLTKVL* 1662866

CYP213A3    Prochlorococcus marinus str. MIT 9303
            YP_001016373 
MASSDDAKLRPLPNTAALSGVLEAFAFFRDPAFAQKRFKRHGNVFETSLLGQPMVFIQGGQAISDLLAQP
NAVEGWWPESVRKLLGSHSLANRNGASHRARRRVIGQLFSASALQRYSAGIISMVKDLADELQAATTALP
LAERMRRFAFSVIATTVLGLEGTDRDELFVDFEIWTRALFSIPIALPGSSFAKALKARERLLKRLQKVLL
KASNGNGGLDLLAGGLDEAGIPLTDEDVVEQLLLLLFAGYETTASSLSCLMRELLLNPQVETWLREEIDG
LDWPPAPEQATTAYDQVNAPKLDAVVSEIMRLTPAVGGFFRRTKCALVIDGVEVPKNRVVQVALAASNRH
GAGDLEAFRPQRHLDDGCSATLLPFGGGERVCLGKPLAELEIRLMVVGLFHQLRLHLIPDQDLTLQMLPS
PTPRDGLLTKVL

CYP213A4    Synechococcus sp. CC9605
            YP_381833 
MATTPLPSTGALSGLGETLAFFTQADFAQRRFETHGDVFETKLLAQRMVFIRGERAIGDMLGQGDALQGW
WPESVRQLLGSRSLANRSGPGHKARRRVVGQLFSSAALARYTPSIEQLVAELCHELITTNTALPLAARMR
RFAFAVIATTVLGLDGASRDALFADFEIWTRALFSIPLAIPGTPFAKAMAARQRLLKRIKGVLQAGTNQG
GLDLLSGGLDEAGIPLDDDDLAEQLLLLLFAGYETTASSLSCLFRALLLNPEVESWLRDGLNKDPASPKL
DATVMEVMRLTPPVGGFFRRSLAPIELAGVAVPEGSVIQVVLSPTSDGDDDDLASFRPQRHLDGSFKQTL
LPFGGGERVCLGKALAELEIRLMAVGLLQAVELQLQPGQDLALQLIPSPTPKDGLLVQAAAR

CYP213A5    Synechococcus sp. RCC307
            YP_001227362 
MSASAEQAESITCSLARSGSMPAKPLPNTGALSGLKETLDFFGDPGFAQRRFETYGDVFATKLLAQPIVF
IRGERAINDLFSQSDSLEGWWPESVKKLLGSRSLANRSGAGHKARRRVVGQLFSSAALARYTPSIIGLVD
ELADELINADGPVSLAGRMRRFAFAVIATTVLGLDSESREALFADFEIWTKALFSIPLAIPGTPFAKAMG
ARQRLLNRIKAVLQEGSNQGGLDLISGGLDEAGIPLDDDDLAEQLLLLLFAGYETTASSLSCLFRALLLH
PEVMEWLSSDVMASPWPAATSPQSEKLDATVLEVMRQTPPVGGFFRRSKQAIELADVAVPENSVIQVALT
PTAATSGTDLSEFRPQRHLDGSFEQTLLPFGGGERVCLGKALAELEIRLMAVGLLQKVQLQLVPDQDLAL
QLVPSPTPRSGLMVTATER

CYP213A6     Synechococcus sp. WH 780
             YP_001224729 3
MVTFVLPCVMAAKTLPSTGAVTGIKETLDFFGDPQFAQKRFKAHGDVFETRLLNQRLVFIRGEQTMADLF
AQGDALEGWWPESVRQLLGSRSLANRSGDGHKARRRVVGQLFSAAALSRYTPSIAALVEELADELIQAKA
PVQLVPCMRRFAFAVIATTVLGLDASDRQALFADFEIWTRALFSIPVAIPGTPFAKALEAKKRLLGRLKQ
VVAQTSAERGGLDLLSGGLDEAGIPLTDDDLVEQLLLLLFAGYETTASSLSCLMRALLLNPEIEQWLLPE
LLDQPWPNLESRSCPRLDATVLEVMRLTPPVGGFFRRTKQTIQLAGVAVPPDRVIQVALAPDLGDGSCDL
AEIRPERHLDGSFTQTLLPFGGGGRVCLGKALAELEIRLMAIGLLQRVHLGLTPNQDLTLQQIPSPSPRG
GLLVTASARHKS

CYP213A7     Synechococcus sp. WH 7805
             ZP_01123846 
MTARSLPSTGAVTGLKETLDFFRDPQFAQKRFTAYGEVFETRLLNQRLVFIRGEQPIADLFAQGDALEGW
WPESVRQLLGNRSLANRSGEGHKARRRVVGQLFSAAALSRYTPSIAALVEELAEELIQAKAPVQLVPCMR
RFAFAVIATTVLGLDASDRQALFADFEIWTRALFSIPVAIPGTPFAKALEAKKRLLLRLQQVLAQTSTRR
GGLDLLSGGLDEAGIPLTDDDLVEQLLLLLFAGYETTASSLSCLMRALLLNPEVEQWLLPELLDQSWPNL
DARSCPRLDATVLEVMRLTPPVGGFFRRTKDTVQLGGVAIPPNRVIQVALSPDLGDGSCDLADIRPQRHL
DGSFTATLLPFGGGERVCLGKALAELEIRLMAVGLLQRVRLELTPDQDLTLQQIPSPSPRGGLLVRASAR
DTSR

CYP213A8     Synechococcus sp. CC9311
             YP_730662 
MMAHAHLPTTGALTGVFESLAFFRDPSFAKRRFRAHGDVFETCLLGQRIVFIQGDQPIADLLAQGGCLEG
WWPKSVQLLLGSRSLANRNGDGHKVRRRVVGQLFSSAALRRYTPEISVLVQKLVDELLNSTSPQPLAPRM
RRFAFSVIANVVLGLDDRNRDECFADFEIWTKALFSIPISIPGTPFAQAMNARTRLLTRFKQLLANDTPL
RGGLDLLRAGVDESGISLDDDDLAEQLLLLLFAGYETTASSLSCLFRALLIDPTVNTWLLSELDAKSAQD
DLDRSLPRLDATVLEVMRLTPPVGGFFRRTKAPVILSGIEVSADRVIQVVLTPSSPSDDSDFFDFRPQRH
LDGSFHQTLLPFGGGERVCLGKALADLEIRLMALGVLKNIELQLHPNQDLSLQQIPSPTPRDGLVITSQR
RLE

CYP213A9    Synechococcus sp. CC9902
            YP_376971 
MSRPLPSTGAVTGIVEAINFFRDPDFATRRFTEFGDIFETSLIGQRLVFIRGDKAIADLLAQGDAVEGWW
PESVRQLLGSQSLANRNGSDHKARRRVVGQLFSSAALKRYTPGMIGLVDELSQELLEETKPIRLADRMRR
FAFRVIATTVLGLEGSDRDALFHDFEIWTQALFSVPIAIPGTPFANALAARRRLLDRLRDVLEQADQNRG
GLDLLAGGLDEAGQPLTADDIVEQLLLLLFAGYETTASSLSCLMRACLIEPHVEPWLREELDGLEWPPQG
DATTAFDGNRAPRLQAVVTEVMRMTPPVGGFFRRTCRPIELANILIPKGHVVQVALASSNRAGSSELNEF
RPQRHLDGSNKPTLLPFGGGERVCLGKALAELEIRLMVVGLLKRVQLSLAGDQDLDLQLIPSPSPKDGLK
VVAKHYAPADAKA

CYP213A10    Synechococcus sp. BL107
             ZP_01468069 
MSRLLPSTGAVTGILEAIGFFRDPDFATKRFVEYGDIFETTLIGQRLVFIRGDEAIADLLAQGDAVEGWW
PASVRQLLGSQSLANRNGSEHKARRRVVSQLFSNAALKRYTPGIVGLVDELSHELLQETKPIRLADRMRR
FAFRVIATTVLGLEGSDRDALFHDFEIWTQALFSVPIAIPGTPFANALAARRRLLDRLREVLEQADQNRG
GLDLLAGGLDEAGQPLTADDIVEQLLLLLFAGYETTASSLSCLMRACLIEPHVEPWLREELEGLEWPAQG
DATTAFDGLRAPRLQAVVNEVMRLTPPVGGFFRRTCRPIELANVLIPKGHVVQVALAASNRAGSSDLNEF
RPQRHLDGSNNPTLLPFGGGDRVCLGKALAELEIRLMVVGLLKRVQLSLAVDQDLDLQLIPSPSPKDGLK
VVARHYAPDDARG

CYP213A11    Synechococcus sp. RS9916
             ZP_01472377 
MTRSPSARPLPTTGAITGVGEAIAFFRNADFAQQRFERLGDVFETKLIGQRLVFIRGDAAISDLLGQAEA
VEGWWPESVRRLLGSRSLANRNGAAHKARRRVVGQLFSSAALQRYSPRIVEQVNALAQDLLNSTHTPIPL
AERMRRFAFSVIASTVLGLDDNDRDALFGDFEIWTRALFSVPLAIPGTAFAKALAARERLLIRLKEVLAK
ADGSRGGLDLMTGGLDEAGLPLSDDDLVEQLLLLLFAGYETTASSLSCLMRELLLQPTVDQWLREETNAL
AWPPHDAEAAMAYDSQRAPRLNAVVQEVMRMTPPVGGFFRRTTGAVTLAGVEVPAGSVIQVALAASNRHG
AGDLDAFRPSRHLEPGNGGPTLMPFGGGERVCLGKALAELEIRLMVVGLLQQVDLELTPDQDVSLQLIPS
PTPRDGLRVRATADHERHPSLKTD

CYP213A12    Synechococcus sp. WH 5701
             ZP_01086392 
MSGVLETLAFFRDPDFARSRFERYGDVYETTLLGQRTVFIRGGQAVGDLFAQGDAVQGWWPDSVRKLLGP
LSLANRNGVDHKARRRVVGQLFTTVALKRYSPAIVALVNELSHDLLGCAAPVALVPRLRRFAFSVIASTV
LGLDPVDRDALFVDFETWCQGLFSLPFALPGSPYARARQARGRLLLRLGSVLNKAQAAVAAGKPLAAGGL
DLLAGGLDEAGLPLADDDVAEQLLLLLFAGYETTASSLSCLLQTLLQHPAELAWLQQELGALSWPPPQGE
ATTAYDAIRAPRLDAVVKEVMRLTPPVGGFFRRTLEPIALAGVLVPADRVVQVSIAASHRHGREDEDLEV
FRPQRHLAGDSTATLLPYGGGERVCLGKSLAELEIRLLTVGMLKQLMLVLKPDQDLTLRVIPSPSPTDGL
LVRPLPRATGLHSPVR

CYP214A1    Trichodesmium erythraeum IMS101
            GenEMBL NZ_AABK02000024 
            74165..75511 gene = Tery2345
            36% to 120A1
MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVY
QKYGPVYKTNFLGKNFIYFQGYEAIKFILTNENKYFTYSQILRNYQRIFGENDITVLA
GKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKWIKSDYVDLYSEINNYTLDMI
LKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFNQFEQIIVR
RKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTS
EHLDVLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDC
SFQGFRIPKGWHAYYYISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGG
ARECIGKEFAYLVIKIFISALLDNCSWKFKENQDLTINTFPVARPAHKIEVCFTPK

CYP215A1    Thermobifida fusca
             GenEMBL AAAQ01000026 
             complement(53223-54434)
             35% to 127A3
MPAPIRIQQCPVSHTDFSTDTEIYG
HYAMLDAEREASRFRFNDTTDRGFLMIQRYDDVVEGFQHHETWTTKVRSAINPDSRSGTA
LLPQDLNGEAHAKLRRVLNPFFSPAAVRRMEPMAVARCIELIEELQPKGSCDFVAEFAIR
YPTDLFLALLGLPVSDGEFFLPWSETVFAGFFGEDPAKVAEARKNIIDYFTETIRERRAN
PRDPKEDMVTRLLEARIDGTPIPEEDILTICLTLMLAGLDTTRSALGYIYAHLARNDADR
QAIIDNPDLVPRAVEEFLRMYPLVFQVGREVQEPTEFHGLDLQPGDVVWLGIAQANRDPR
KFPEPDRFNPDRKGVNQHIAFGAGPHRCLGMHLARLELAIVLREWHQRIPHYRIREGVTL
TERGGQLTLPTLPLEWEA*

CYP216A1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000039a 
            98411..99769 gene = Tfus2242
            37% to NZ_AAAQ01000042   Thermobifida fusca
            39% to 157B1
MTRSPSPPIRLYQAADPTALWPALLAEYGEIAPVELEPGINGWL
LLSWRLNREVMRDAETYARDPDRWADMANGRIGPRSPLRVLYGKYQSALYSDGADHKR
YRAALTAALDSLSLRQVTGHITAAADQLIDAFCLHGKADLVTQYTRQLTVTVLARLFG
LGPAETMRICLEMQAMWDEGPNAFPALMRIAEMLTELARKRRRTPGKDLASVLVAQGL
SDVEVRDNLLLIIAAADDPVTHLTGNTIRMLLTTPESRAALTTSPGLISEAVNTALWT
TPPLQTLVGRYPVRDVELAGVPIRAGECLVLGFAAASLDLAQHSDADTMSTNRAHLTW
GVGPHSCPLRGQDMALAIAETAVERLLRRLPDVALAVPPEQLRWRPSLAVRGLESLPV
RFTPTPVSNPGGTEWDSPADPTPSTSIRPKESTSPRSDANSSTKARWYAWLFPGTWKS
GL

CYP217A1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000029b 
            complement(46399..47577) gene = Tfus0917
            39% to 145A1
MTTLAPSTDLDFYSEEVILNPYDTYRRLRDTAPAVWLERYQVWA
VTRYDDVYAALHDHRTFASGYGVALNDPLNEKMKGSALVSDPPYHDHVRGVMGGPLTP
RALRKHHDYFQERADALIDHLLELGRFDGVRDFAQIFPLSVVPDLLGWPAEGREHFLD
WASAGFQALGPMNERALRDLPTLKGMWEYMAEIVRPGRLAPGSWGAALVEAAEKGEVD
KQLLPALIGDYLVPSLDTTVSALSTMLWQLGENPDQWRMVREDPSLIPNVLNESIRYE
APIRALSRYVTEDTEIGGIPLARGSRALMVYASANRDERHRKDPDTFDVTRSNANTHV
GFGHGIHGCVGQGLARLEGHSLLNALVRKVARIEVGQPTWRVHNTIRAMTTLPVEFSA

CYP218A1    Thermobifida fusca
            GenEMBL NZ_AAAQ01000042b 
            complement(348226..349737) gene = Tfus3015
            35% to 156B1
MILNCEHDPVFHVPVVSTPGRWSVTHPLYPVGNSDTPHDRNAGS
SEGCPVSLDDREALHRLAVPVYGELDADLPDVLERLRKQFGRIAPVEVAPGVAAWILL
GYDVNRRVLQDSAEFARDPRRWREAREGRATPEKVPGPFWYFRNALASDDPDHSRYRP
VIVDALSGITADGTRLAVRRIATELLAPVALTGKADLVADFAFRVPLLVLNRYFGLSA
EEGLELVELMRQVWDGGEEAEKARLGLFAYAQSVTARRRENPGSDIVSRMVRHPNALD
DEEIAHQLILLISAAHDPLMNLIANTAHTLLTDEEVRYDLAGAHLRVEEVVDTVLWRS
PPITLLPGRYPVRDTLLEGAYVQEGDCLIIGYGPAHADPAVAPYIDPLSPSGIRGHLA
WGTGPHACPAQRISRQIAVDAVSALLDLLPDVRLAVPPESLERRRSLFAHGLKALPVT
FTPVDITPPTEAPWQQSQNPSSSSQENPASKPSSSVKRGRLPEWWSKVWKFGR

CYP219A1    Novosphingobium aromaticivorans
            GenEMBL NZ_AAAV01000054 
            complement(4309..5553) gene = Saro0307
            41% to 107AA1
MEAEAAIPPLDTSDPALIPDPWPTFTTLRERDPFHWSKYGYWVV
SRHEHVRDVLMNRKDFGTGDFAANLRLFYGPDFDVLANPAYRWLSEVFIMQDPPQHTR
IRNLVVGSLTAKRVRAMEPRIREIAQALTDGFKARGSADLITEFAYKFPVMVICDLMG
IDYEASEMADLIAAIPEAFTVFEARILSPEELALANRRILELEAFFQAQFENRLAHPR
GDLLTSLARTGQEPGGLSVHEAITVTIGLFGAGFETTANIIGNGLHALHANPEQWARL
VADPSGMASGACEEALRHQSSLIATYRTALADTSVCGHPVSAGQRVLTLIGAANRDPR
KFADPDRFDIARNDADHLTFGGGIHFCVGAELARIEARVAFEHLARELPQMQVDTGGA
CWRENFLFRGLTGLEARWPAQA

CYP220A1    Burkholderia fungorum
            GenEMBL NZ_AAAJ02000117
            18981..20198 gene = Bcep1617
            35% to 107B1
MTFIYDPNDPDVRRDPHAVFRKLRETEPVHWSPKLSGWVVTSYE
LASEVLTTNGTYSAERFTAVQQHLSEEKRVTAAEVMRWFQHWMVFRDPPDHTRLRRHM
ANTLNIPVFDARRETVISVVNELLDRIPVGDAFDFFQAFSLWMPGIVVADLLGVERDR
LLEVKQWSDDMMTFIGSARGVPDKYERARRGANGMGTYFLDLIAKRRAEPREDALSRL
IASEVEGQRLSDDELVGCMMMVLNGGHETTANLLNNSMLALAAHPQTVQHLRQHPDEM
AAAVEEFLRYDSPVLSIGRIVTEDTELGDQEIAAGDRVFAMLVGANRDPEVFSDPDEL
RTSRNPNPHMAFGKGPHFCLGTPLARLEGQIALTAILERFSSIELCEPVESIPWLNSL
VTHGPTRLPLRLK

CYP221A1    Pseudomonas fluorescens PfO-1
            GenEMBL NZ_AAAT02000002
            complement(179015..181831) gene = Pflu5298
            36% to 107B1
            N-term is 38% to acyl CoA oxidase of Streptomyces coelicolor
MSDPLLKLLQKPLFDPEKRHRVSLREYMDLNIDRMRAIIGNGLM
TNAMWLSQPRQSEFRLMLERAALIGAVDYSLLACIVDHFIAGDAFFAHGSQHQIAQYH
QEICQLKAVYAFGCTEIASGSDVANLQTTINYDPHKHCLILNSPTPQSCKFWIGNALH
AAVVVMVLGRLIVKGVDEGLHWFRVRIREQENGPLLPGVRITTCDPKGGIHANQVAGI
RFCNMKLPLDALMQRYARFSAQGVFSSEIPPKERLKSAMQTFIQERLFLIAGARGAAS
MCVYLAYRFACHRLVKGNEGSQSLLTKALFRQRLYAEQLKVLALKLLEQAVLSRFEAC
WHQPARRKELHILAAVVKSVGTWLGLEVMSACRELCGSQGFHHHNRIVTLVMDHGIST
TFAGDNNILCCQVARDAINRPRFANENIAQRIESLIVDQCRRAGDFSHRQAVALTYAR
ALDLIINEGKHHPLVTSEIFEDIVHVFSPKLYEWELVASTKLEQNATEAQLILLNELL
KPPSELVRAPIDKKNYVKHF  TKPLYDNKPDFSNRNTIRNPYRAYTWLRKHQPVYWCEH
LQAWFLTRYCDVIAAQADSRRFSSNRMQQLIDARVPENKRTHLNEFIKLASRWMYSQD
GDTHKASRHLLGNAFTPRSIEALRAIIQDITDRELSRLHGQTDLKTALFDRVPALILA
RLYGMKDDEALRLRRWTRDIVMFLGGSQDADQGPDQALEGIKEMYACFAELIEQRRRQ
PGDDLVSRVLESGQNSAASLDEVLAQIVFILVAGYTTSADQMCLGLLHLLKHPQQLEA
LLADPTLIGSFIEEMLRFDPAGSLSHRILMEDVTIDNITMKKGNLVYLIRASANRDPE
KFHAPNTFDIRRARNEHLTFGKGEHFCMGTSLFRLEAEIVFTSLLKRFPDLQLIARRP
AKWRNSNLQFRGLKTLPVDLGTGV

CYP222A1   Thermobifida fusca
           GenEMBL NZ_AAAQ01000022.1 
           52729..54468 gene = Tfus0480
           33% to CYP101
MSLRGLPGTAPRQRAGSPGPASFLKRRRDAAPRPTISLDGDGPL
RAGLGSIPGRRLQFGAHLFVEHVGVPVFFARRKHVGRGHVAHTVPLALLSVDSDAHVA
LLRDQRSLFSLAILTLMLLSITIITRTAIKITHHTRSRHRPYPHSSQRTSAHEPGQER
AHSMSNPTRCPVIHFDHHSPEHAKDPVGAYRALRQTHKRGWTEAHGGYWVLSDYQSVF
DAARDDDLFSSTREAAGTDGLAIVIPPTPMYHHIPIEVDPPEFRKYRKIVNQVTAPAA
VERMKEMVERYTVAFVDSVIEKGECDFTTIIGVPAIVTIDWLGLPVKDWKRYADAHRA
TLAEPQDSEAFRHAVEVELPALSQQMWDTIRARRQEPKDDVISFLVSQKVDDRPITDE
EVFAMVDLLVSGGTGTTASLVSQALVWLAKNPDVRQELIDDLSLLDRAVEEFLRVFSP
TQALARTVTRDVEFHGCSMKKGDRVLLSWASANRDEEQFENPDTIDIHRWPNRHVAFG
IGVHRCAGSHLGRFMAKRLLQEILTRMPDYTIDFDALVPFHDQGTNVGFRSIPAKFTP
GKRVLPLSEAVIG

CYP222B1    Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE9564 40% to CYP222A1

CYP223A1   Novosphingobium aromaticivorans
           NZ_AAAV01000162.1
           complement(33798..34988) gene = Saro2671
           31% to 194A1
MHRAMTTTVQDFDPEVPEDFDSPHAEYARLRRECPVAHTNGLGG
FWALTRYEDVKRAASDSTTFITSVQNVVPKVAFTGRRPPLHLDPPEHTPYRKALNPLL
SLERSEAFAGKARELTRKLLAPMVENGGGDICVELSSYLPVHVFGEWMRMPEEWLDTL
HDAGRAFILAVHSNTPERMKETSLRLYDMARGLIAVRRENPQDPALDPTSALLAARHE
GEPLPEELLVGTVRQVLVVGMVAPMVMIGNICVHLSRDKALQQQLRADPSLVPAAIEE
FLRLYTPYRGFARTAVCDVDMGGRTIPKDEAIALVYASANRDEDVFPDGDKFILNRPN
IAQHLAFGRGPHNCPGVHLGRMQLRVALEEILAATREFELSGPVSVSRWPEVGALSVP
LRFV

CYP224A1   Novosphingobium aromaticivorans
           NZ_AAAV01000154 
           complement(32211..33443) gene = Saro2336
           36% to 127A2
MTLLFQPSPPDHVPGERMVDFDMFHVPEGQDDPVEIWHDLVRRG
VPRIFYTPRNGGHWVFLDYADIVEAYRDHTVFSTYQTPVPPIEPFPVVQPQGVDPPAH
NVFRRLLAPMFTPTAVRGMIGELERRASELIDRFAARGECDFITEFAERFPTSTFLHL
FGLPEEQLDAFLALANVFFRSTDAETRARNIGEIYAVLDTLFREKERNPGNDIASAIV
AARDEEGRQHPWEDILNCGFLLFVAGLDTVTNTMAYIWRYLATTPAARRHFRERLDDP
DAFLRAIEELMRINAVSNLFRRVTHDCEYKGVQLRRNDRVVLPNTVANRDPRVFSDPQ
AIDLDREVNVHLTFGVGPHRCIGSVLAKREVMVSLQQWLRRIPEFELAPEQPAGSAFG
GSVMGFTALRLRWVRVEA

CYP225A1   Novosphingobium aromaticivorans
           NZ_AAAV01000151 
           17550..18872 gene = Saro2207
           34% to CYP124
MPSPPRLAGTSTASGLEDQMQFPFSRSTNPNVDLSSLDAFNEGA
PFATFDRMRREDPMAWSEMVNGDRGFWSVTRHADLLELNRQADLLSSAKGIRMEDQTE
EEYEARKTFQETDAPHHRGFRALVSKAFSKGTVAGFEDQIRKIVTDLLDVALAEGEFD
AVDRIARRLPMQMLAQIMGVPQEDGPWLVEKGDALISNSDPDYTDFVVDQVDTEAYRM
LPFRSPAAVELFDYANGLLDRMDAGEQIGVLNLVREPTSTGTRMSRDEFRNFFCLLVA
AGNDTTRYSISATIHALANNPHLLQALKDGDFTSWEAAADEMIRYASPTTHFRRTATR
DFTFHDRHVKAGDKVLLWFISGNRDETAILDPYTINLRRERNPFLSFGQGGPHICLGM
WLAKLEVAIVMQELAKRLSSIEQVAEHSYLRSNFIHGIKHLPVRIVAR

CYP226A1   Burkholderia fungorum
           NZ_AAAJ02000018
           25472..26761 gene = Bcep5906
           61% to 226A2 30% to 109B1
METGMTSPAKSNALESAFESTASNYRGSDVDLNAIYRDMRRNSP
VIAQDFMASLGVPNIAKLDPNRPTFTLFKYKDVMSVLRDAANFTSGFIAEGLGSFFDG
LILTGLDGEAHRRARALLQPVFLPEVVNRWRESKMEPIVRNEFIGPMVPQRRADLMHF
GLHFPIRLIYSLIGFADDRPEQVEQYAAWALAILAGPQVDAQKAAIARKAAMEAAEAL
YAAIRSEVAVVRAKGAEGEDLISRLIRAEYEGRRLDDHDIATFVRSLLPAAGETTTRT
FGSLMTLLLERPALLERVKADRSLVSKAIDEAVRFEPVATFKVRQAAVDTGIGGVSIP
KGAMVQCIVSSANRDEEVFENSETFDIDRKPKPSFGFGFGPHMCIGQFIAKVELQVAV
NAILDLLPNLRLDPDRSPPKIVGAQLRGPDAVHVVWD

CYP226A2   Burkholderia fungorum
           NZ_AAAJ02000018
           complement(62819..64102) gene = Bcep5938
           61% to 226A1 32% to 107N1
MSTTLENPMLDLEAAYHAVSDTYRGPDIDLQALCREMRHKNPVM
KGDFVATHLGIPTNAGASAAKCEVTLFRYQDVLAVMRDATTFTNGFIAEGLGGFFDGL
IILAMDGDAHRRARGLLQPVFMPETVNRWRPELDRVIREDFLAPLVPNRHADLMDFGL
YFPIREMYALMGFPTDDTAKFNQYATWALAMVAGNQIDPGKIRIFGPIAAAAVKHLYD
AVMEVVLQRRAAGADGNDLISRLMRAEYEGHKLDDHEVTTFVRSLLPAAGETTTRTFS
SVITLLLERPALVERVRNDRSLIPRLIDEAVRYEPVATFKVRQAARDIEIGGVKVRSG
GLVQCMVMSANRDEDVFENADTFDIDRKPKPSFGFGFGAHMCIGQFVAKIELQCAVNA
ILDLFPNVRLDPARPAPKIAGAQLRGAKSVPVIWD

CYP226A3   Pseudomonas diterpeniphila
           GenEMBL AF274704 7700..8974
           P450 monooxygenase (tdtD) gene
           72% TO 226A1 32% to 159A1
           note="abietic acid metabolism"
MSGPAHSNLEQVFANVASNYRGADVDLHAVYREMREKSPVLPEN
FMARLGVPSIAGLDPNRPTFTLFKYDDVMAVMRDATNFTSGFIAEGLGSFFDGLILTA
MDGEAHKNIRSLLQPVFMPETVNRWKETKIDRVIREEYLRPMVASKRADIMEFALYFP
IRVIYSLIGFPEDRPEEIEQYAAWALAILAGPQVDPEKAAAARGAAMEAAQALYDVVK
VVVAQRRAEGATGDDLICRLIRAEYEGRSLDDHEITTFVRSLLPAASETTTRTFGTLM
TLLLERPELLARIREDRSLVGKAIDEAVRYEPVATFKVRQAAKDVEIRGVAIPKGAMV
SCIVTSANRDEDAFENADTFDIDRRAKPSFGFGFGPHMCIGQFVAKTEINCALNAILD
LMPNIRLDPDKPAPEIIGAQLRGPHHVHVIWD

CYP226B1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0272
           40% to 226A3, 38% to 226A2, 37% to 226A1

CYP226B1P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           100% to 226B1 M. marinum in conserved region

CYP227A1   Nostoc punctiforme
           GenEMBL NZ_AAAY02000109 21775..23139
           very poor similarity to P450s
           gene = Npun0867
MTVNIMTLKDKVLKGQDRQLWLAPILAKVGYDTAIGKFLRLIFY
YTDASIILKAWRDFLYIRKDNIGDKYFAVDQAIMHSSHSQVRELMQTQPQLRGNDLGI
IRILAPSYLLDNPLSLGTNGNEHTGLRTVILQALPEPSQKIDFLGNLVEQSLLEAAKQ
GKLHIGNDLPKIILSILHQLVFQISLSEEEITASDSYIKGLALASLPNFINKYLLAIL
TAPKIRHRQYLTNRYKQSAKWASYFETGAQYQLNEHQIANTLFDMIHIAGTAGTSALL
GSVIGVLCLDNDLRNDVVSEVNAVWNGKKTLDPDALEQLTILNQVILETARLYPPVRF
VSQLTNEGGEVEIGEQKCPFQKGTRLLGSIFTANRDANRYQNPNDFDLTRNFSDILSW
NGEGHERACPGKSLSIGFIKIFCLHLFQNYQWDSITEVKWDFEKVTAVTPNNLVLQGF
AQRL

CYP228A1   Magnetospirillum magnetotacticum
           GenEMBL NZ_AAAP01002937 216..>1496 
           Gene = Magn3794
           34% to 107N1
MGPRPHARLVRRPPLPARARGHPVTGTALAPAPAGLAAAMRWEE
RVQRGAHPLVYPAIRALRHRGPVVRVPGIGVVVSDAATARAVLLDTEHFSKVGPGSPS
DLWTPVLGPSVLLNMEGADHARLRRALSGLFTPRAVRDLVAVSVPDVLAGLAPRLLAG
ERVDLVAETATMAGTVVCAMTGLPPTDSAVREAMTAAQSVVGLVRLHRRSLTPSQVRH
ARAVLARLSAPARDAYRAGDPATVPGRMRELGLSEDEALGAVGAFVLTGTETIQSFVP
RLVALTADTGWLDRLLAADPGAGPEAAALRGRVVEEALRVTAPTPAMLRSVRAATTVG
DVRVRAGDRVVIATISCCKDAGPFDPDAPVDPAVRHLWFGAGPHFCLGMPLATAQVDA
VLDALRPVAAAGRSLQVTDRAVARGVLIPAYRSLV

CYP229A1   Pseudomonas fluorescens PfO-1
           GenEMBL NZ_AAAT02000063 complement(5763..6863)
           Gene = Pflu1316
MDPIIAATHADPYPYYAELRAAGGLTFHHGLKLWVASSARAVCA
VLAHPDCRVRPVQEPVPKAIVDGMAGKVFGLLMRMNDGEAQRCPRSAIEPPLGLIDRE
EVGALVSARLITNDSDGLYKAMFRGPVCVVASLLGFTPAQARVISELTADFAACLSPL
SNDLQLAAAHRAAEQLRGYFIEMLADPNPFLADIRQRFVGNEEVLLANLIGLCSQTFE
ATAGLIGNALVALHRQPELRNASVDSLLAEVQRFDPSVQNTRRFMANSCEIDGVRLEA
GDVILVLLASANRDPALNENPDRFRVDRPNRRSFTFGSGRHQCPGQTLAMTIASATLT
EILARNIDPGRFTWHYRPSLNGRVPMFSEVQP

CYP230A1   Pseudomonas fluorescens NCIMB
           GenEMBL AF318063 58574..59938
           mupirocin biosynthetic gene cluster.
           Gene = mupO
MTSWEREVSRGAGNRQLPVVKGWPLLGSALALIRNPLGFLQTTR
STYGDVYRVKAAHMNFVVLAGMEANRFVADKGKDCFVSSGFWEATLQEMQCPHSFIGV
DGDAHRFQRNLMKPLFSKSAFNERIPMLAQIFTDTLQARYGVDQKVSALFRHVLSQQI
GGSLQGYQPTPDEVEALMRYQNTAMNVCALKKWPRLALRLPGYRAAKKQVQALADRII
ESERTQEQTQGYFQTLKEKGQMVQPQWFTPGDMRNHAIISYLAGIDTVGATLSFMLLE
LFKQPHLHQALRDEVDACFSQGLPDADGLENMETLKNFIREVMRLYPTAYAVRRTRRK
DFEFQGYSIDKGQDIILFTTANHTDPAWFKNPQVFDITRYEEPRLEHRASGAWAPFGR
GPHTCIGAGLANILLSLNLALFLYHTDLRPACKLSDIKMDFSNPAAGLSERFAISFTPRNRP

CYP231A1   Ferroplasma acidarmanus Archaea; Euryarchaeota
           GenEMBL NZ_AABC02000007 complement(32352..33461)
           Gene = Faci1014
           38% to 109A1
MEHDVFQYYRKMRKESPVHFNNDTGSWDVFDYKSVYFVLMNPDI
YSSDPSYAGNIPENRQGPGASFITMDNPDHKELRNVTTPYFLTSKITGYRDMIESTSK
RLMEGINKNSDFIRDYAVMLPVTVISELLGVPENDRSKFKEWSDYIIGNRSDAGFQDL
NRYMYSTMAEIFKTNTEDNIISTINKGLFHSEPLSINQKIGYVMLLVIGGNETTTNLI
GNMVKVLSEHPEIADKLRQEPELKKGFIEETLRYYSPIQFLPHRFAARDSVLNGQEIK
KGQRLSIWLGSANRDGAKFEDPDTFNMERQNNDHLAFGMGIHMCLGSPLARLEAEIAL
NDILNKFKHVKINAEKTSMLKNPMVYGFSTMQLDD

CYP231A2   Picrophilus torridus, Archaea; Euryarchaeota
           coded_by="complement(AE017261.1:1398572..1399603)
           also YP_024177 in Entrez protein 
           Paul Ortiz de Montellano
           Submitted to nomenclature committee May 25, 2006
           Gene PTO1399
           53% to 231A1
MRLNDPVHYDGAWHVYKYSDVKHVLMNDKIFSSNPGNRYSNAGG
ISFITMDNPEHKEFRDISAPYFLPSKINDYKDFIEETSNDLIKNIDNKDIISEYAVRL
PVNIISKILGIPDSDMPLFKLWSDYIIGNKRDENFNYVNNRMVSRLLEIFKSDSHGII
NVLAGSSLKNRKLTMDEKIKYIMLLIIGGNETTTNLIGNMIRVIDENPDIIDDALKNR
SGFVEETLRYYSPIQFLPHRFAAEDSYINNKKIKKGDQVIVYLGSANRDETFFDEPDL
FKIGRREMHLAFGIGIHMCLGAPLARLEASIALNDILNHFKRIKIDYKKSRLLDNKMV
LGYDKLFLS

CYP232A1   Ferroplasma acidarmanus Archaea; Euryarchaeota
           GenEMBL NZ_AABC02000015 12150..13295
           42% to 109B1 40% to 119A1
           gene = Faci0565
MEIPTYKEEPFEWYREMRKNSPVYREGNMIHIFKYNTISKILSD
HQNFSSQFRDLLGEEMAAMLNEKTTPSILLLDPPLHTTLRGLVGSAFTPRSIELFEPR
IREIARMLAHAIVEKENSDIVSDLSYQLPIRVISEMLGVPESDSEIFRDWSDKLATSL
GRGPDIETQYDMADYFYKKIDRNSKGNNLISRLSTVEMDGRKLSDKEIAGFAILLLVA
GNETTTNLITNAILSLYDHPEIYNEMRKTPSLIPGVVEETLRYRSPVQSTRRYSKIDT
EIEGEEILKNDILALYLGSANRDEEAFEDGESFNPYRKEKRHMAFGQGIHFCLGAPLA
RLEARIALEEFSKAVPGFEIEKPSPDDRIDSDIMYGFRKLNLKVNRS

CYP232A2   Picrophilus torridus, Archaea; Euryarchaeota
           coded_by="AE017261.1:98333..99481
           also YP_022863 in Entrez protein
           Paul Ortiz de Montellano
           Submitted to nomenclature committee May 25, 2006
           Gene PTO0085
           60% to 232A1
MYIPSYKEEPFEWYKSMRTQRIVREGNSVHVFKYNDVVTVLSNH
NVFSSQFRDLLGDDIKNELDSRAAPSILILDPPRHTELRGLVSSAFTPRKIESYDNYI
RELAAKMIENIIEKRRCDLVSEISYPLPIMVISNMLGVPEKDLKKFKEWSDALATSLG
RGPDLRTQREMSEYFLNMIDRDSNDDNLISRLSNVSIDDKKLTDQEITGFSILLLVAG
NETTTNLITNALIELSNHPDIYKELVDNNKIAGDIVEETLRFRSPVQSTRRYAKYDYQ
INGFNIYKNDFIFLYLSSANRDEEIFKDPDNFNPFRENKRHIAFGNGIHFCLGAPLAR
LESRIVLEEFAKRIESFSIERLNPDDRIDSDIMYGYKRAIINVKKINQ

CYP233A1   Gloeobacter violaceus
           GenEMBL NC_005125 complete genome
           complement(2058447..2059673)
           40% to 107X1
MSALPPPRFNPFDSEFRQDPYRVYAHLRVAAPIHRSLGMWVLTR
YADVLAVLKDPHFSSSQIPLAVRQRSERPDQAQSHPLARLAAKSIVFTDEPDHTRLRH
LVVRAIKRRTPEQEQAHLTRIASALLERVGPKGRMDAVADYAERLPLQFMAESMALPP
DSWQTVRDWTHQLRYLLEPGLMGRGDFERVQAVLDEVIAFFEDMLAVRRQQPGDDLIS
ALDAAHREAQADRLSDEEIVYCCIMMFVAGHETTRSLIASGLLALLQHPEQLAYLRMH
PERMGAAVTEMLRYESPLQQTKRRATAAVAVGGRTIQPQEQVLLCLGAANRDPARFEQ
PDRFDITRTDNGHLAFGQGMHHCLGAALAQMEAQVALRVLLERFANLTLQDTPEWLEH
SFILRGLKTLPVQWDR

CYP233A2   Frankia sp. CcI3
           YP_480709.1
           ABD10980.1
           64% to CAJ62096 same as ABD10980
           76% to YP_001506247 EAN1pec
           55% to CYP233A1 Gloeobacter violaceus
MSTGGMTSPTPSTATADTATADTATAEATRAPIRFNPFGAEFRRSPYPLYARLRGAQPVHRTLGMWVLTR
HADVRGVLHDRTFSAGLIPQLVSRQASRLSRDDVARIGRLATKSLVFTDNPDHARLRGLVNRVFTAQAVA
ELRPRVHEVAERLVRRAWDDGGMDVVADLAGPLPLTVMCDWMALPDSLRERVGPWTHDIRFLLEPGLMKT
EDFTRVSDVVETFAQALDDVVTERRSRPGDDLISRLLAARTAGGDRLSDEEVVFVCIMCFVAGNETTKSL
IGNGLLALLQHPDQDARLRRRPELLGGAVDEALRYDSPLQLTKRVATREVEIDGSRIRAGDQVLLCLGAA
NRDPAVFSRPDEFDITRDARGHLAFGHGMHGCLGGILAQLQAQVALDRLYRRAERLELLVTQPDWQDHSF
IVRGLKQLPVSVRGVG

CYP233A3   Frankia alni ACN14a
           YP_713660.1
           CAJ62096.1
           63% to YP_001506247 EAN1pec
           49% to CYP233A1 Gloeobacter violaceus
MPTPSTASTASAAPTAPAAARFNPFSAAFRADPYPVYRELRRTSPVLRTMGMWVLTRHADVRAVLHDRTF
SAGLIPRLVSRAAGGDALGSVAAGNSGRSGNAERMVQLAHTSLVFTDNPQHARLRALVNRVFTTAEVTRL
RPRIAAIARGLLDRALSDCGGLDAVTDLAGPLPIAVLSEWMALPDDVRGEVGRWTHDVRFLLEPGLMAPG
EVDRVGEVVATFADAMAGVIAARRARPGDDLVSRLLAARTGGGDRLTDTELGFLCIMCFVAGVETTTALI
GNGLLALVHHPDTAALLHRRPELVAAAVEEALRYDSPLQLTKRLATRDVELGGSRIRAGEQVLLCLGAAN
RDPAVFDRPDTFDITRPAGGHLAFGHGMHGCLGGMLARAQAEIVFGCLTGRAERLAPAVDRHGDAGGRDL
PRQEHSLIVRGLTSLPVALAGAW

CYP233A4   Frankia sp. EAN1pec
           YP_001506247.1
           ABW11341.1
           51% to CYP233A1 Gloeobacter violaceus
MTPRAHEAAVDEAAAAVDGTPAGRAPGGGAAGGGRAAIRFNPFGAEFRRDPYPLYRRMREAQPVHRTMGM
WVLTRHADVQGVLRDRTFSAGLIPQLVSRRAGQLARANVDRVVRLGEKSLVFTDNPDHARLRGLVNRVFT
ATEVAALRPRVEEVAGGLVRRALAAGGMDAIADLAAPLPVTVMCDWMALPDGLRAQVGPWTHDIRFLLEP
GLMRAGDFEHVCDVVETFARALDGVVAERRQRPGGDLISRLLAARTAGGDALTPEELIFVCIMCFVAGNE
TTKSLLGNGLLALLRHPDQAARLHRAPELAGDAVTEALRYDSPLQMTKRVATRDVDVDGRRIRAGDQVLL
CLGAANRDPAVFDRPDEFDVTRAPKAHLAFGHGMHGCLGGLLAEMQAQVVFERLFGATTSIEPRTDQLEW
QDHSSIVRGLRHLPVTLHPAAPR

CYP234A1   Photorhabdus luminescens subsp. laumondii TTO1
           GenEMBL NC_005126 complete genome
           complement(4894114..4895217)
           locus_tag = plu4183
           very poor match
MMNVLINEYKKKMDSVRLGDPERKGFFYDAKQAIWHCYSYDICS
YFLNSDYVTKKKLSIPLEIFSASDQSRVARFILYLNNSLIFNDDKYNTDAVSFIRGKF
NEMNFEVIANDLLSPLKQCDLLTAKHLRGVNNLLAASLVGLKASAFFSAHALNVGMFF
DGSMSGRAHFVSIAESFIAIYQQVLRQITINGGAEDVIHIEKFVADLSVTFIAAHETT
MQLIIATFLYIKSHVITVTENNIKSIVTETYRLSSPVLAVNRVFKERLIYKNSCFNKG
DRVLFYTGLANFDATVFDHPYQFQLDREGCPLSFGVGVKKCIGMNIAIHFTCQLITKI
LSCYQLDDVEIHEVTVGSLAIGCSKFTLKISKK

CYP235A1   Streptomyces antibioticus 
           GenEMBL AJ002638 184..1389
           35% to 131A1 no heme sign.
           Gene = oleP1
MEDSELGRRLQMLRGMQWVFGANGDPYARLLCGMEDDPSPFYDA
IRTLGELHRSRTGAWVTADPGLGGRILADRKARCPEGSWPVRAKTDGLEQYVLPGHQA
FLRLEREEAERLREVAAPVLGAAAVDAWRPLIDEVCAGLAKGLPDTFDLVEEYAGLVP
VEVLARIWGVPEEDRARFGRDCRALAPALDSLLCPQQLALSKDMASALEDLRLLFDGL
DATPRLAGPADGDGTAVAMLTVLLCTEPVTTAIGNTVLGLLPGQWPVPCTGRVAAGQV
AGQALHRAVSYRIATRFAREDLELAGCEVKSGDEVVVLAGAIGRNGPSAAAPPAPPGP
AAPPAPSVFGAAAFENALAEPLVRAVTGAALQALAEGPPRLTAAGPVVRRRRSPVVGG
LHRAPVAAA

CYP236A1   Microscilla sp. PRE1 plasmid pSD15
           GenEMBL NC_002806 40616..41776
           32% TO 109A1 C-TERM
MKKDLIPDPFEKTREAAGYGEMNDQNDPVTMILRLKDVRKCAHN
FKTFQSGARPGRIVVPSEVSIRDTRQIPFEVDPPEHTDYRALVEPWFKRPLEAEYREK
LSQQIGYIVEERLARDAVEVVEEFSLPLQSRALTLLLNIPIEEAETWIKWGTHVFRSE
DSPVDGDKAKILYDYIDQQIDRALEKPGEDLYTVLLNSEINGKKLSREEVKGVMILTF
AGGRDTVINAVTNSVAYFAVHPESLELLRKEPEITGRAVEELIRYFAPLTHMGRVVTE
DTQVCEYAVKADSRISLVWASANRDSSVFEKPNEVVLDRKINPHVSFGFSHHNCLGAT
HARQIMHILLKTLAEKVGSIEIQEHEDNIETWGEFERKVGYDRLKVQFNPLQ

CYP237A1   Pirellula sp.
           NC_005027 complete genome 6102783..6104327
           34% TO 184A1 C-TERM
           gene = cypX
           locus_tag = RB11252
MRNGTSYLQNFFPGYRRLSRLPKQCLAINPFAGDCMPSRVRLLA
PRSDRPTQPFPHRWNYEDPVRILETYFWKADEEQGPGRHNRYLDVPGFAPVLVTRDPG
MIRAIATATGDREGQFDRDTLPSVGIARATGTDTLLYANGAEWKKQRKIAACPFGKTT
LFQPEQFCEFADTFRETVRGRIDVLRQHLTASGKKTVDIQLEPEVKVVMLEMLTNNFF
GADISYEELREKYVPALERVIDHIVKDTVKNRLGIPWRKFPSVSDRIVRAKADDATFE
ELTQRILVPRGEKKALWKQFKSDAPDAKLISNLKVFLAGALEATTSYATWAISHLARH
PDAQEKVFEEVKDIDVYTPEILAGAKYLRAVLDETLRLTPSLYFLPRRATADTWVTSA
DGRKMFIPWGTHLLLDVWHANRHEDHWGVQVSGYPANEFEPDRWRILAEWGRATKDTL
HFGFGHGPRVCPGKHLGELEVGLTVGALVKTFRFQSESPENLARAGVSTKPADGTRVC
MSLRLS

CYP238A1   Pseudomonas putida KT2440
           NC_002947 2211866..2213101  
           26% to CYP101A1 30% to 107X1
           locus_tag = PP1955
MEILDRPQAPSDFNPMSEQSFRDPASICQRAREETPVFFYAPLG
VWMVTRREDAERVLSEWETFSSLANSPNVPEEFRSRFAPSVMADSIVAIDPPRHTQAR
NVIQRGFMKPKIDPLEPIIEQRAHEIIDRFAGESGTEIMNNYCLELTTRTLMALYDLP
LEDRPMFERIRDVSIKVLASVYEPMQEPEKSRVWNEYVSGYEYFYQLVEQRRNSDARD
IISTMASQKDNQGNPALSTERIALHLVEIAFAGTDTTAQMMANAILFLDSHPEALAAA
KADKTLWSRVFEETVRRRPSAPFAGRITTTEVEIQGVKIPAGSPVWVSLAAANTDPRH
VGCPMNFDINREAPQDHLAFTKGRHTCPGAPLARLQGATGLRVLFERLPELKVVPDQP
LNFAPMALLPVRLSLQVIW

CYP239A1   Pseudomonas aeruginosa strain SG17M
           GenEMBL AF440524 34312..35472
           Integrated gene island PAGI-3(SG).
           38% to 194A1 96% 14 diffs to CYP239A2 AJ311159
           gene =ORF SG16"
MKDVNEVARNFDFHGEALDDIFDTYSTLRHGCPVGRSENYGGFW
FLTKSDDIFAAEQDPEAFSVYPSMMVPSVSEGIQLPPIDIDPPEHTAYRRILLPLFTP
QELKKLEQPIRDTARKLAEEFAKEGSGADASYHYSRPLPTIIFSRLAGYPEQDWPKFD
KWVDDIIYERVEKPEVANQASKDVFSYFENLLDNWKDDSESANLIDYLCRAKINGRPL
TRDELLRYCYLLFLAGLDTTAWSIRAGLWYLANNPADQQKLRDNPDLIPLACEEFLRT
LSPVQVMARTCLKDTVIRDQEIKAGERVMLVFGAGNRDEEVFPNPDKIDIERQENRHL
AFGGGIHRCLGSNLGRRELVVGIEEFLRAVPQFKPADPSEKWHGVGPLKLAF

CYP239A2   Pseudomonas sp. KIE171
           GenEMBL AJ311159 4194..5354
           isopropylamine degradation gene cluster (ipuABCDEFGH genes) 
           38% to 194A1 96% 14 diffs to CYP239A1 AF440524
           gene = ipuD
MKDVNEVARNFDFHGEALDEIFDTYSTLRNGCPVGRSENYGGFW
FLTKSDDIFAAEQDPEAFSVYPSMMVPSVSEGIQLPPIDIDPPEHTAYRRILLPLFTP
QELKKLEQPIRDTARKLAEDFAKEGTGADASYHYSRPLPTIIFSRLAGYPEKDWPKFD
KWVDDIIYERVEKPEVANQASKDVFSYFENLLDNWKDNGESANLMDYLCRAKIDGRPL
TRDELLRYCYLLFLAGLDTTAWSIRAGLWYLANNPEDQQKLRDNPELIPLACEEFLRT
LSPVQVMARTCLKDTVIRGQDIKAGERVMLVFGAGNRDEEIFPNPDKIDIERQENRHL
AFGGGIHRCLGSNLGRRELVVGIEEFLRAVPQFKPADPSEKWHGVGPLKLAF

CYP240A1v1   Bordetella bronchiseptica
             NC_002927 3943708..3944865 
             extremely poor match may not be a P450
             locus_tag = BB3721
             100% to B. parapertussis 98% to B. pertussis 7 diffs
MIADTARQHRGDIMQPADPLEAVAHPDPYPYYAALARERPFYHD
DRLGLWVAAGPQAIRAVLTCPAARVRPPGEPVPAALGAGPAAQMFGRFIRMNDGAVHE
RLKPMLTAYLTQRTAADLAEPAWPAIGNDPAQVDRYLYQAPVHAQACLMGLPDEVAAS
CAREIEAFMAACRPGADAAAVARADQAAQALQARMLAHLRAARGDAALGVLRRLALAG
GVEADALAANLAGLLLQSCEAGAGLLGNALVHAGRLSPAAAAAAPDLLHTCVEIVTHV
ARHDPPLHNTRRFLAAPATLLGQSVPAGAGILVVLAAAHALAEGAWPWTFGAERHACP
GRTPALLHAAQALAHALRHGVDAPALARRVRYRPLPNARVPRFHFPPGDTP

CYP240A1v1   Bordetella parapertussis
             NC_002928 3527249..3528406
             locus_tag = BPP3270
             100% to B. bronchiseptica

CYP240A1v2   Bordetella pertussis
             NC_002929 2545572..2546720
             locus_tag = BP2405
             98% to CYP240A1v1 7 aa diffs
MIADTARQHRGDSMQPADPLEAVAHPDPYPYYAALARERPFYHD
DRLGLWVAAGPQAIRAVLTCPAARVRPPGEPVPAALGAGPAAQMFGRFIRMNDGAVHE
RLKPMLTAYLTQRTAADLAEPAWPAIGNDPAQVDRYLYQAPVHAQACLMGLPDEVAAS
CAREIEAFMAACRPGADAAAVARADQAAQALQARMLAHLRAARGDAALGVLRRLALAG
GVEADALAANLAGLLLQSCEAGAGLLDNALVHAGRLSPAAAPDLLHTCVEIVTHVARH
DPPLHNTRRFLAAPATLLGQSAPAGAGILVVLAAAHALAEGAWPWTFGAERHACPGRT
PALLHAAQALAHALRHGVDAPALARCVRYRPLPNARVPRFHFPPGDTP

CYP241A1X   Enterococcus faecium
           NZ_AAAK01000185 complement(2963..4222) 
           Gene = Efae1119
           36% to 152B1
           renamed CYP152M1
MKEVPVVDIKITDLKKLYQKGYNMLEELRHEADAPVVKAKIFNK
EAITIYGSSAAKVFYDPRNFKRKGAMPKLVLKTLFGQGGVQTLDGAAHHHRKNIFMDL
MTPERMEDYHRILDKNLTQALEAQHGQFELFDLSKMVFFTSICEWAGINLSAISKDEV
EKLAEYQISMISGTFTSPIDHIKGVENRKKSEKWAQGLIEEARQNPVAGKENVALYAF
ANATDLDGQLLPLEVAAVELLNIIRPTVALTVWAALMGHALFSRPDLYQQLKNDFSTL
QDPFIQEMRRYYPFFPMLPAISLKEVEVDGYRIPEGSWVILDLYGTDHDERTVEAPDS
FMIKRYVGKAKDISYKEEYEMIAQGGGNFRQMHRCAGEWITLHSLRVFSDQLVNKFEF
SVPEQDWTIPFNQFPTYPNSRALLYKN

CYP242A1   Kitasatospora griseola
           GenEMBL AB048795 2479..3729
           36% to 107P1
MADLETKFPRYELISSGKYVDRIPELHELREKSPIAWVPVMDAA
FLTRHADIVRVLKDHRMAPANLTQGIRLLSPEQQEELEPLSSAVKKWMGHTVPADHQR
FIGLLKRYFTPAMIDRMRPRVRQLSHELLDAVEPAGRMDIVSDIAYPLPACVIAEMLG
VPMDNRAQLLAWSADIGAIAEIVSYDRLMECQRSLLAMQDFVLEVVKERRAEPKDDLI
SMFVAAEREGLVSEAEILSNCVMLLFSGHETTGGLITSGLVQLFDHPDQLELLKSDPD
LMPGAVEEMLRLAGPASVISRVSTEPVEVAGSSIRSGAAVPPGADGGKRDPRVFEDPD
RLDATRRPNDHLAFATGMFYCLGAALARMEADEFFRILLDRFPDVNPGYETPDWQPVL
LISRRLKTLPVNLRGVGGSGAGDE

CYP243A1   Mycobacterium avium
           AF232829 complement(389..1609)
           38% to 222A1
MTPTRSTSTNWPSTPNCGNDVRSRGTRTTAGSGSSAATTPSAKP
PQRRHFRPQSTSRTPQTAWTTRARWASRDPEGQPALGLGEVDGPYHQALRHALAPFFS
PGAVEKLNPFMEQSAHWFLDQQITTGQMDLVLDYASPVPAILTMKLMGLPYDNWRLYA
NLFHSVMAVSQDSDEYAAAIAKVPAMMHEVLDYAATRRAKPEEDLTSFLIRFEFDGHR
LTDEQLLNILWNLIGGGVDTTTSQTALTVLHLGTHPDLRQQLIDHPELYRTATDEFLR
YFSVNQTLSRTVTHDVVLAGQRLRKNDRVVISWLSANHDENEFDRPDEIILDRAPNRH
VAFGLGPHRCIGSHLARLMSEVMVRAVLXRIPDYQVDVENVHQYLGNPSMTGLGQLPV
TFAPGKSRKTLRPW

CYP244A1   Streptomyces sp. TP-A0274
           GenEMBL AB088119 complement(5410..6594)
           staurosporine biosynthetic gene cluster
           31% to 107B1
           gene = staN
MTDMPVDPGPFDCMPELLAAARVAPVVRIPYLEEHAWVVCDPEL
VRTALTHPKMAKDITLVPQFMRKPGLMVGSQPPPEYARAMIMSDGEDHARIRRVHQPV
LSPRNTQRWGERVGVKVGGFLDELEQSRASDSAEVDVVTDYTHRVPLAFISEMLGLPL
EAERRLRSITDVMLYSSDYPARQEAVGALFGAVESWVQNPAPLRDGVITGFLAAADGP
DKVTEGEVIVWTVGMIITGYETTGSLISASLYEALRRPPEERPGTDEEIKSWIEEALR
VHPPFPHPTWRFPTEDIELGGYLIPKGAPVQVSIAAANRQPGEGADSFEAARGGHGHL
SFGLGMHYCIGASLVRLEAQIAVREFLRRFPKARLSDGSAVQWESEWMIRRLSALPAVLN

CYP245A1   Streptomyces sp. TP-A0274
           AB088119 13260..14513
           staurosporine biosynthetic gene cluster
           38% to 107P2 53% TO Lechevalieria (10860..12053)
           gene = staP
MASATLPRFDLMGWDKKDIADPYPVYRRYREAAPVHRTASGPGK
PDTYYVFTYDDVVRVLSNRRLGRNARVASGDTDTAPVPIPTEHRALRTVVENWLVFLD
PPHHTELRSLLTTEFSPSIVTGLRPRIAELASALLDRLRAQRRPDLVEGFAAPLPILV
ISALLGIPEEDHTWLRANAVALQEASTTRARDGRGYARAEAASQEFTRYFRREVDRRG
GDDRDDLLTLLVRARDTGSPLSVDGIVGTCVHLLTAGHETTTNFLAKAVLTLRAHRDV
LDELRTTPESTPAAVEELMRYDPPVQAVTRWAYEDIRLGDHDIPRGSRVVALLGSANR
DPARFPDPDVLDVHRAAERQVGFGLGIHYCLGATLARAEAEIGLRALLDGIPALGRGA
HEVEYADDMVFHGPTRLLLDLPDAA

CYP245A2   Lechevalieria aerocolonigenes
           GenEMBL AF534707 complement(10860..12053)
           36% to 107P1
           gene = rbmE
MKPFDLKAFTGADLADPYPVYREYLTGDPVHHNGEAWYVFGYDG
VAHVLTSRDYGRRGPGGRATPIPPSHDTLSRIVENWLVFLDPPRHTALRSLLAKEFSP
AVVTGLRERVRKIAGELLAGLGDAGEIDLVEDFAAPLPILVISELLGVPARLRSWFRR
CAVDLQEASTARATRNPGALARADGAASELVEFFGGELGTRKPDDEDLVALLVNAQRR
GEALTDEEIVSTCVHLLTAGHETTTNLISKSVLALLANPAAAAEPLAGLDVTPQVVEE
LNRFDTPVQMVTRWAHQDTALGGKPIRRGDKVVLVLGSANRDPAAFAEPDRLDLRRDS
RRHCGFGLGIHYCLGAALARTEAEIGLSVLFTNFPGLRLGGEPVRYADDLVFHGPARL
PMLTR

CYP245A2   Lechevalieria aerocolonigenes
           GenEMBL AB090952 15478..16671
           rebeccamycin biosynthetic gene cluster
           gene = rebD  
           100% to AF534707 rbmE
           100% to Saccharothrix aerocolonigenes rebP

CYP245A2   Saccharothrix aerocolonigenes 
           GenEMBL AJ414559 15358..16551
           gene cluster for rebeccamycin biosynthesis.
           gene = rebP
           36% to 107P1, 100% to AB090952, AF534707

CYP246A1   Streptomyces acidiscabies
           GenEMBL AF393159 537..1724
           40% to 105M1
           gene = txtC
MESPATQVDPANSPLEPYHIYPEAKSCPVAKVGLWNGTPAHVFS
GYEDVRTVLQDRRFSSDSRRPNFTELTPTLQSQAAAPPFVRTDNPDHRRLRGTIAREF
LPKHIELLRPAIREIVQGVLDGLAETAPPQDMLEAFAVPVASATVFRLLGIPAEDRAL
LTRCVKGVVSAVGSEDEGAEVFRTLGEYIGGLVQDPSELPEDSLIRRLVTGPYQEKQL
TFHETIGVILMLIVGGYDTTASTISLSLVSYALQPEKFSVVHEHPERIPLLVEELLRY
HTVSQLGLGRIATEDVEVGGVTVRAGQMVVAALPLANRDESVFPNPDELDFDRPSVPH
VGFGYGPHQCVGQALARVELQEAIPAVIRRLPGMRLACALEDLPFRHDMATYGIHELPMTW

CYP246A1   Streptomyces scabies
           SCAB31761
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           100% to 246A1 Streptomyces acidiscabies GenEMBL AF393159
           MOST LIKE CYP105 FAMILY 40% TO 105M1, 38% TO 105B1, 38% TO 105B2

CYP247A1   Actinomadura verrucosospora 
           GenEMBL AF411574 1..>954 runs off end
           40% to 162A1
MRARAPLHHQVLPDGREFWSVTRYDDVCRVLGEHQRFTSERGTV
VTHLGVDDVAAGTLLTSTDPPRHTLVRRAIGARLTARAVAPWRERIPERDWDELVQLT
AMVTAPSDPHFRHGSEAATLAIAHHELVTYVKEWAARRRSAGGDDGSLLDHLMTVRVA
GAPLTDEEIALDGYSILLGANVTTPHTVSGTVLALIERPEQFGKVQADPSLVPNLVEE
GLRWTSAACNFMRYAVDDVRIAGGTIPARGAVVAWIGSANRDESQFADPHTFDVTRNA
SRQVAFGYGPHYCVGAPLARLTLRVFFKELLRRFGSLSSGGS

CYP247A2   Frankia alni ACN14a
           YP_712777.1
           CAJ61205.1
           75% to CYP247A1 Actinomadura verrucosospora
MRLSPGAASDVDLDRLDLFDLDLYSSGDPHAIWEVMRAQAPLHHQVLADGRAFWSVTRYDDVRAVLGDHR
RFTSERGTVVTHLGEDDLTAGKLMTSTDPPRHTQVRRAIGTRLTARAVASRQNQIRQAIVRFLEPLLDGG
TDDLAERALRLPMVVAGPLLGIPERDWDELVQLTAMVTAPSDPHFQCGGRAATLAIAHHEIVTYVTDWVR
RRRSSGERDGSLLDHLMSVRAGDAPLTDEEIAYDGYSLLLGANVTTPHTISGTVLALVELPEQFDKAQAD
PTLVPSLVEEGLRWTSAACNFMRYAACDTEIGGGTVRRGDAVVAWIASANRDESRFADPHEFDLTRDANR
HVAFGVGPHYCIGAPLARLTAQIFFDELLDRCASIELGGAPEHLRSYFIAGMTHLPVVARKRRSS

CYP248A1   Micromonospora echinospora
           GenEMBL AF497482 72606..73799
           gene = calO2
           calicheamicin biosynthetic locus
           34% to 107H1 
MTAFDPTDADVRRDPYPSYHWLLRHDPVHRGAHRVWYVSRFADV
RAVLGDERFARTGIRRFWTDLVGPGLLAEIVGDIILFQDEPDHGRLRGVVGPAFSPSA
LRRLEPVIAGTVDDLLRPALARGAMDVVDELAYPLALRAVLGLLGLPAADWGAVGRWS
RDVGRTLDRGASAEDMRRGHAAIAEFADYVERALARRRREGGEDLLALMLDAHDRGLM
SRNEIVSTVVTFIFTGHETVASQVGNAVLSLLAHPDQLDLLRRRPDLLAQAVEECLRY
DPSVQSNTRQLDVDVELRGRRLRRDDVVVVLAGAANRDPRRYDRPDDFDIERDPVPSM
SFGAGMRYCLGSYLARTQLRAAVAALARLPGLRLGCASDALAYQPRTMFRGLASLPIA
FTPGG

CYP249A1   Rhodococcus ruber
           GenEMBL AF333761 12042..13244
           Chauvaux,S., Chevalier,F., Le Dantec,C., Fayolle,F., Miras,I.,
           Kunst,F. and Beguin,P.
           Cloning of a genetically unstable cytochrome P-450 gene cluster
           involved in degradation of the pollutant ethyl tert-butyl ether by
           Rhodococcus ruber
           J. Bacteriol. 183 (22), 6551-6557 (2001)
           gene = ethB
           37% TO CYP217A1
MTLSLATAQERYATDADVFAHDTLVDPYDTYRSLRDIGRVSYMT
RYDTWALTRYDEVRHALGDWQTFSSAQGIGMSTALNEAWKDFAPCKDGADHLPMRKLM
MQDLGPKAAAAYKEKIQQAAVTLVEELLDRREFDAVLDFAQMMPMRVFMEVLGVEPDI
EQRRTMLHWGTDTYNCAAPDGLYDDTLPSMDKLYSWALENITPETAREGSVAASTWES
VERGDITDVQAVATLAAYVTAGLDTTAGTLGNTIAQFAANPDQWAIVRDDPKTIPGAI
LEGIRFDSVAQWFTRVTTRDVEYDDIVIPAGSRTYHSYAAANRDERHYRDPDSFDVLR
NPTDHVGFGYGPHMCVGKSVSNTEMIALWTELGRRVDRIEQIGPKKQHINNLIRSLDS
LPVRIYPK

CYP250A1   Arthrobacter aurescens
           GenEMBL AF146701 
           32% TO 219A1 N-TERM ONLY
MKEPLDFADPTLYQNPVPAFNKMREEHPVFWSDSAGSWVVSRHA
DVVRVLNNLEDAQASLFKINDYAEQCPFGKGTAISRGIENALVTTDLPDHPRLRRHTA
PLLTRRSVERDYAETVEQTVIALLEGIEEDTRFDVLDSISVPLPLAVVTKLIGFDAED

CYP251A1   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           38% to 183A1 and 171A2
           clone name SP0759

CYP251B1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2317 42% to CYP251C1

CYP251C1   Amycolatopsis mediterranei U32
           GenPept ADJ49978.1

CYP251D1    Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2320 42% to CYP251A1

CYP252A1   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           39% to 197A1
           clone name SP0812

CYP253A1   Streptomyces peucetis
           No accession number
           Niranjan Parajuli
           Submitted to nomenclature committee Nov. 2, 2003
           36% to 197B1 
           clone name SP0913

CYP253A2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_4844
           85% to CYP253A1 Streptomyces peucetius 

CYP253B1   Streptomyces peucetis
           No accession number
           Pramod Shrestha
           Submitted to nomenclature committee May 16, 2008
           Clone name SP_4173 
           44% to CYP253A1 Streptomyces peucetis

CYP253B2   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_4843
           83% to CYP253B1 Streptomyces peucetius SP_4173

CYP253C1   Streptomyces peucetis
           No accession number
           Pramod Shrestha
           Submitted to nomenclature committee May 16, 2008
           Clone name SP_9081 
           45% to CYP253A1 Streptomyces peucetis
           42% to CYP253B1

CYP254A1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha02824
            Submitted to nomenclature committee 12/13/04
            36% to 239A2

CYP254A2    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha02853
            Submitted to nomenclature committee 12/13/04
            68% to 254A1, 67% to 254A3

CYP254A3    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha02973
            Submitted to nomenclature committee 12/13/04
            70% to 254A1, 37% to 239A2

CYP255A1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha04605
            Submitted to nomenclature committee 12/13/04
            54% to 255A2

CYP255A2    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha05312
            Submitted to nomenclature committee 12/13/04
            54% to 255A1

CYP255A3    Rhodococcus sp. R04
            No accession number
            Riu Xue
            Submitted to nomenclature committee March 17, 2011
            58% to CYP255A1 Rhodococcus sp. RHA1

CYP255A4    Rhodococcus sp. R04
            AFAQ01001933.1 15866-17097 (+) strand
            Riu Xue
            Submitted to nomenclature committee Feb. 28, 2012
            62% to CYP255A3 Rhodococcus sp. R04

CYP255A4    Rhodococcus pyridinivorans AK37
            AHBW01000047.1 54163-52952 (+)
            98% to CYP255A4 Rhodococcus sp. R04

CYP255A frag Rhodococcus rhodochrous
            Swiss P31718 (20 amino acids)
            Eltis L.D., Karlson U., Timmis K.N.
            Eur. J. Biochem. 213, 211-216 (1993)
            85% to CYP255A2 rha05312 (3 aa diffs no start Met)
            TSTLSWLDEITMEELERNPY

CYP256A1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha09714
            Submitted to nomenclature committee 12/13/04

CYP257A1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha10525
            Submitted to nomenclature committee 12/13/04

CYP258A1    Rhodococcus sp. RHA1 
            No accession number
            Marianna A. Patrauchan
            Rha10666
            Submitted to nomenclature committee 12/13/04

CYP259A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_4259
            36% to 117A3

CYP260A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_1461
            48% to 260B1, 35% to some CYP107 members

CYP260B1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_4416
            48% to 260A1

CYP261A1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_182
            No strong matches

CYP261B1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rita Bernhardt
            Submitted to nomenclature committee Oct 18, 2007
            Sce5725
            49% to CYP261A1

CYP261C1    Photobacterium profundum strain SS9
            YP_133374.1
            see link
            Dmitri R. Davydov
            P450-SS9
            41% to CYP261A1

CYP261C2    Photobacterium profundum strain 3TCK
            ZP_01217946.1 
            Dmitri R. Davydov
            P450-3TCK
            97% to CYP261C1

CYP261D1    Moritella sp. PE36
            ZP_10899073.1
            Dmitri R. Davydov
            P450-PE36
            47% to CYP261C1

CYP262A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_2000
            39% to 205A1, 252A1, 38% to 253A1

CYP262B1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rita Bernhardt
            Submitted to nomenclature committee Oct 18, 2007
            Sce1860
            41% to CYP262A1

CYP263A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_4484
            No strong matches

CYP264A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_5791
            42% to 264B1, 37% match to some CYP107s

CYP264B1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_7808
            42% to 264A1

CYP265A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_7503
            37% to 151A1

CYP266A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_5168
            40% to 107AA1, lower to other CYP107s

CYP266B1P   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rita Bernhardt
            Submitted to nomenclature committee Oct 18, 2007
            Sce6630
            45% to CYP266A1 C-term only, probable pseudogene

CYP267A1   Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rolf Muller
            Submitted to nomenclature committee 8/5/05
            Clone name sce_040811_619
            41% to 107P1, 40% to 195A2, borderline CYP107-like 
            but also similar to CYP195

CYP267B1    Sorangium cellulosum So Ce56 (myxobacterium)
            no accession number
            Rita Bernhardt
            Submitted to nomenclature committee Oct 18, 2007
            Sce7167
            43% to CYP267A1

CYP268A1   Mycobacterium avium subsp. Paratuberculosis
           GenEMBL AE017235.1 
           CDS complement(103932..105242)
MTGVIAERIGIMAVLTGESGTDRSGRPYDEIDLSSRAFWSGTAA
ERERSFAVLRAERPVSWHPPVEDSLLPDPTDPGFWAVTRRADIVTVSRNNDVFLSGHG
VMFESIPAELLEASQSFLAMDPPRHTKLRKLAHAALSPRQVRRIEDSIKANAKAIVEE
LRSAGSGCDFVDHCAKELPIRTLSDMMGIPESERERMAHATDALVSWADPEFLNGRPA
LEVLLENQMYLHQVVGDLATQRRERPGDDLISSLVTAEVDGDRLEDAEVAAFFVLLSV
AGNDTTRQTISHTLRALTVFPDEKFWLLEDFGHRIGTAVEEFIRWASPVMTFRRTAAA
DVELGGQTILAGEKVVMFYPSGNWDTEAFDHPERLNLGRDPNPHVGFGGGGLHFCLGA
HVARAQLRAIFSELFRQLPGIQAGEPTYLAGNFVHAIRAMPCTF

CYP268A2   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3761
           78% to CYP268A1 Mycobacterium avium subsp. Paratuberculosis
           41% to 124A1 40% to 125A1

CYP268A2P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           95% to 268A2 M. marinum

CYP268A3   Mycobacterium smegmatis
           MSMEG4612 TIGR
           77% to 268A2 Mycobacterium marinum
           76% to 268A1
           50% to CYP268B2, 52% to MSMEG3700
           51% to CYP268C1 Mycobacterium vanbaalenii
           48% to CYP268B1 Mycobacterium vanbaalenii
           45% to CYP142B1 Mycobacterium vanbaalenii
           formerly 124B1 but new sequences caused a split of 124B from 124A
MTVLPITRPYDAVDLSSRAFWATTAADREVAFAQLRAERPVSWHPPVEDA 
LMHDPDDKGFWAVTRHADIVAISRDSETFLSGQGVLFENVPQELLEASQS 
FLAMDAPRHTLIRKLVHSAFTPRQVARIEDSIKANAAAIVAELKAAGSGV 
DFVDHCAKELPIRTLSDMVGIPEGEREKVAHAADALVSWADPIYLAGRHP 
LEVLLENQMYLHQVANTLAAERRENPGNDLISALVHAEVDGDRLTDAEVA 
AFFVLLAVAGNDTTRQTTSHALKALTDFEDQRAWLMEDFDDRIGVAVEEM 
VRWASPVMTFRRTAAVDVELGGRQIAAGEKVVMFYASGNWDTTVFDRPDV 
LDLGRKPNPHLGFGGGGRHFCLGAHVARTQLRAIFGELLHQLPDIRAGEP 
EYLQGNFVHAIRAMPCTFS

CYP268A4   Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_1278
           53% to CYP268A2 Mycobacterium marinum MM3761 
           55% without the small insertion

CYP268B1   Mycobacterium vanbaalenii PYR-1 
           ZP_01206299.1, EAS24061.1 
           49% to 268A2
MSGSPDRRRSADHDHPAAVAACRQLYKLTVKCHANSVTAPSLHEREHSAIDITSHDFWSRPFAQRDESFA RLRAGDGLSWHAPFPSLFPMEEPGYWAVTRRADIAYVSQHPELFTSERGVALDPMPAEVQRFASFFLTMD PPQHTTYRRLISSAFTPRNVRQIEEQIQRNAVAIVDDLVGAGDIDFVADCSARLPMLTIMEMLGVPGADQ PAVALAAEKLFSMSDDEYSSLEERAANTLNEIMLLSSTGAELAKFRRAHPGDDLMTGIVNAEVDGQRLTD EEIGAFLILLASAGNDTTKQTTTHAMMALVENPQQRAWLMADFDGRIGAAVEEFVRWSSPVLQFARFATR DTEINGQPVAEGDKVGLFYCSANRDEAVFDNPAGFDLSRSPNPHLGFGGGGPHFCLGNQLAKAELRNLFR 
ELLTRLKTVEFGEPDLLHSSFVHGVKRLPAHVR

CYP268B2   Mycobacterium smegmatis
           50% to CYP268A3, 40% to CYP124A1
           78% to CYP268B1
           formerly 124C1 but new sequences caused a split of 124C from 124A
MTVASSAQAREYSPFDITSHEFWSRPFAVRDETFAQLRAAEGLSWHQPLS 
TLFDVEEPGFWALTRRADIQFVSQHPELFTSAQGVALDPMPADVQKFATF 
FLMMDPPEHTVYRRLISSAFTPRNVRRIEEQIHANAVDVVDQLIGVGNVD 
FVEACSAQLPMRTISDMLGVPKADQPALAKAAEKLFSMSDDEYSSLEERA 
VATINEIMLISNTGVELAKFRRANPGDDLMTSIVNAEVDGHRLTDEEIGA 
FLILLASAGNDTTKQTTTHAMMALAAHPDQRDWLMADFDGRIGPAVEEFV 
RWATPVIQFARFATEDVEVAGQTIRAGEKVGLFYCSANRDEAVFTDPQRF 
DLSRSPNPHLGFGGGGPHFCLGNQLAKTELRNLFRELLTRLKTIEFGEPE
LLHSSFVHGIKRVPAYIR

CYP268C1   Mycobacterium vanbaalenii PYR-1 
           ZP_01209026.1, EAS21466.1 
           51% to 268A1, 44% to 268B1, 42% to 268B2 
MQIDEYLAATSDNKPDHCDIDISRKAFWARPADEKMEIFAALRAEHPVSWQRPIEGAVVPDPDDPGFWAV VRHADIRQVSHDNRTFISGQGVMFDRLPPLFLEMALSFLAMDPPRHDKLRRLVNKAFTPRQITRIEDKID LVAKEVVDGFIADPTGEIEFMDRCASRLPLRMFCEMFGVPDHLEERTVEHVIGSVSWSDEEILAGRSAAD MQLESIGGLHQVAQEIIEMRRQQPGDDIISSLVHAEIDGQMLTDFEISSFFCLLSGAATDTTKTTLGHAV RALSLFPEQHAWLLEDFDNRIGTAVEEFIRWATPLLTFTRTAAVETELGGRRIMPGDRVVMIYQAGNFDE DVFDRPRELDLARSPNPHVSFGGGGVHYCLGANLARSMLRAELRELLLRITEFETDAPDMLATNFIHGLK RLPFRFTPQ

CYP269A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3969
           40% to 107E1, 34% to 107G1

CYP269A1P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 269A1 M. marinum in conserved region = ortholog 

CYP270A1X  Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017229.1 
           CDS complement(151750..152955)
           name changed to 190A2
MTKPKLVFDPYSEDYFNNPYEIYRRMREEAPLYYDEKEDFYALT
RHVDVAAAFKDYETYSSARGCDLAMVRRGISPEQKSIIFMDPPEHRHMRSLLNKAFTP
RAIQSQRETIIEVVDKYLSAADPDNFDVVQDFSGPFPVEVITRMAGVPEEYRQQVRHW
IDTSLHHEPGQIEVSEAGMQANIDTAMYYFGLVQERRQDPQDDMISRLIAAEIPGENG
QMRKLDDIEITGFATLLGGAGAETVTKLLGNAAVIFARHPDQWQKLQEDRDKIPGAVE
ELLRYEGPVQYNVRYTLKEAHVSGGVIPAGKPVFLCGAAANRDPEAFTDADTFDIERD
QTEAQHLGLGYGIHSCLGAALARLESRIALERLLDFMPRYDVDWAGCRRVTMQNVAGW
KNVPVKVLR

CYP270A2X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4733
           69% to 190A2 Mycobacterium avium subsp. paratuberculosis
           38% to CYP123A1
           name changed to 190A3

CYP271A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0274
           40% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
           38% to 127A4

CYP272A1   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017234.1 
           CDS 77322-78491
MTEAGGFVDQTVTGVAEPQPMYKALRESNPVFRSTQAVVLSRLA
DIEMALKHTELFSSNMDAVDLGNVRPLIPLQIDPPDHAKYRRILDPLFTPREMARREP
LVTELVNEMIDRFAPRGECDFHAEFAVPLPCTVFLQLLGLPLEDLDRFLLWKDGVIRP
AGDSGFDRRHESSAGVAQQIYEYFDKAIDEHIAVPRDDVLSAMIAADVGGQPLSREEL
LDICFLFLIAGLDTVTDSLDCFFVYLARHPQHRRQLVERPDVLPGAVEELLRWETPVP
GVARVATQDVEVGGCPISKGERVSPLLGAANTDPAEFPDPEIVDFTRSPNRHRAFGGG
PHRCLGSHLARMELRVALREFHRRIPDYEIRPGTQLTYTAALRSVESLPLVFPVR

CYP272B1   Frankia alni ACN14a
           YP_714029.1
           CAJ62469.1
           46% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
MPDDTAGAAAPADGGHGLRAATLDWLEFERQRAEDPRAYFSRLRAKCPVDYDEGHEGWIQILRRAEIDEV
LRNPEVFSNLIPELMSSPLPAIPMGVDPPDHAKYRRILDPLFSPRRMAALEAEVVANTVATIESFLDRGS
CDFATDLAVPLPCSVFLTLFGLPQSELPGLLHMKDALIRPESLTDDPDEKLRIQTEAGTQVFTLFGTVLA
QRRAEPRDDLITELLKAEIEGRPLTEPELLGICFMLMMAGLDTVTISLTCILAYLLEHPEARQRIVADPE
TIPAIVEELLRWETPVMAVPRIVTRDTEVAGCPVRKGEMVHVMLASGNLDPDADPRAGVVDLDRADKRHL
AFGGGPHRCLGSHLARMELRTVLREWHRLIPEYSLAPGASITWNGSTLRGLDSLALTWPTDAGQA

CYP272C1P   Frankia sp. EAN1pec
            YP_001511056.1
            ABW16150.1
            54% to CYP272A1 Mycobacterium avium subsp. Paratuberculosis C-term
            59% to CYP272A1 over 171 aa
            52% to CYP1027B1 over 159 aa
MAQTGTERPLIPLQIDPPKHREYRRILDPLFSPQRMKEMEGPITELARGLVDWESPVMMVARFATQDTEI
AGCPVRKGQVVTDLLGAANTDEREIPEPEAVRFNRDANRHIAFGRGPHRCLGSHLARLELRIALREWHAR
IPDYRVPDGFQPAFTTTIRSLVALPLQLDPSA

CYP273A1X  Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017235.1 
           CDS 255472..256674
           Name changed to CYP187A2
MMTNVPTAAGDETVSLRDPYPFFARKRREAGVFAGTVMDYSKTP
ESLMPKQEYSAVSFDAVNTVFRDGRVFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNL
VSAAFKSKALARWEPTIVRPICNALIDDFIDAGTADLVRQFTFEFPTRVIARLLGLPD
EDLPMFHTRAVQLISYHVDYERAFEASAALKDYFLEQIEQRKSKPTEDIIGDLVTAEI
DGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPDQFAALQADRELLAPAIE
EGLRFETPLTTVQRFTTEDTELQGVRIPARSVIGVCIGSANRDERRWERSEEFDIFRK
HVPHISFAAGEHTCLGLHLARLETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTA
LPVTFDAK

CYP273A2X  Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017235.1 
           CDS 236687-237919
           Name changed to CYP187A3
MPLSTGPTGQPVVPTLDFTGETSPYPFFEHMRRTDPVWHGSLAD
ASQLPEELRPEDEWVLFDYESVSQAFRDDRIFSSHKYDETIGLVMGHTILAMGGREHH
DHRNLVAKAFRATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTL
LGLPAEDLDLFRRLSLDLISIPTDIEAGLNAATELYDYFLKQVEQRRRKPTDDIIGDL
VAAEIDGEKLTDEAIIAFLRLLLPGGLETTYRSSGNLLYLLLTHPEQLAMVYRDRSLI
PMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAF
DIRRPRQAHIAFAGGIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIV
GLTFRSPNKLPVTFAPAA

CYP273A3X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM3996
           85% to CYP273A1 Mycobacterium avium subsp. Paratuberculosis 
           57% to CYP273A2 Mycobacterium avium subsp. Paratuberculosis 
           38% to 159A1, 38% to 159A2, 57% to 273A4

CYP273A3X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 273A3 M. marinum = ortholog

CYP273A4X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4008
           82% to CYP273A1 Mycobacterium avium subsp. Paratuberculosis 
           56% to CYP273A2 Mycobacterium avium subsp. Paratuberculosis 
           36% to 159A2, 57% to 273A3

CYP273A4X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 273A4 M. marinum = ortholog

CYP274A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0283
           37% to 183A1

CYP274A1   Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 274A1 M. marinum in conserved region = ortholog

CYP275A1X  Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017234.1 
           CDS complement(151992..153206)
MVMTGTSAIELYYDPFDSGIDDNPYPVWQRMREEAPLYYNEKYN
FYALSRYEDVARELPNWQTYRSGRGTTADILFSNVEVPPGILLFEDPPLHDLHRRLLS
RVFTPRRMLAVEDLVRGFCVRELDPLVGAGGFDFIRDLGAMMPMRTIGYLLGIPEEDQ
EKIRDRSVANIELSRDSDPAAVDANVFANSIALFADYIEWRADHPSDDLMTELLRAEI
DEPDGTRRPLSRTEVLAYTAMIAGAGNETTARLIGFMGQLLSDHPDQRRELAADPSLI
PGAVEETLRFEPPSPVQARYVARDAEHYGRVVPEGSFMLLLNGSANRDPRRFTDPDRY
DIHRQGGGHLSFGQGLHFCLGSALARMEARVAFEEVLKRWPDWEVDYANAERARTASV
RGWARLPVVTGG

CYP275B1X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0928
           57% to CYP275B2
           52% to CYP275A1 Mycobacterium avium subsp. Paratuberculosis
           37% to 123A1 
           name changed to 189A6

CYP275B1PX  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 275B1 M. marinum in conserved region = ortholog
           name changed to 189A6P

CYP275B2X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM4753
           57% to CYP275B1
           54% to CYP275A1 Mycobacterium avium subsp. Paratuberculosis
           37% to 123A1 
           name changed to 189A7

CYP275B2X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 275B2 M. marinum = ortholog
           name changed to 189A7

CYP276A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM1564
           36% to 107AA1

CYP277A1X  Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017231.1 
           CDS 236434..237804
           Name changed to CYP185A3
MSVAEPKRDIAGLPLAPKNPLSYRERLRAIKEFHTGTNKLRDAG
GPVTRVTLGPRWLISPIVLATSPQGIRDIVSVRDGSIDKTSTVATELRRLLGPNLFVL
PHTEWLPRRRTLQPVFTRQRVREFGGHMAEAAESVCAGWPEDTEIDLDAQCRTLTLRA
LGRSVLGLDLDERSDAIAEPLRVATSYAVRRALRPLRAPEWLPTPSRRRARAAAGAIR
ALADEILQACRADPGREAPLVHALIAATDPETGQALSDKEIRDEMIIFLFAGHDTTAT
TLTYALWALGRHPEYQARVAAEVAELPDRHLTPDDVARLGFTVRVLQEALRLCPPGPT
GTRMATRDVEVAGYRVEAGTMLAFGRMAVQTDPSLWDAPLRFDPDRFDPRRAGDRDRW
QYLPFGGGPRSCIGDHFAMLEATLALATIVRRVEIESLSDDFPLAVPFTMVAAAPIRA
MVRRRR

CYP277A2X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0852
           58% to CYP277A1 Mycobacterium avium subsp. Paratuberculosis
           35% to 184A1
           Name changed to CYP185A4

CYP277A2X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 277A1 M. marinum = ortholog
           Name changed to CYP185A4

CYP278A1   Mycobacterium marinum
           No accession number
           Tim Stinear
           MM2877
           35% to 107L1 

CYP278A1P  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           99% to 278A1 M. marinum in conserved region = ortholog

CYP278A2   Mycobacterium vanbaalenii PYR-1 
           ZP_01209042.1, EAS21482.1 
           37% to 107U2, 34% to 109B1
           83% to 278A1   
MTMSSTTASALELLTTASGIADPYPLYNQLRRLSPVAGYRDWPPGTIPGADEPVTAWALFRYDQVFEAAR DSATFSSRDPLQEASSAPSLMLVNTDPPKHEIERKLVSQAFSPRRVKRLEGWLGELVPRLLEDLGSGEVD VMEFAAEVPTRAMVRLLGLPDGDHVRFKRWANAFMLSSSLTPDERIASNDEMVAAFAGRLTEHTARLAEQ APTDDVEDAEDLISALLRAEVGGQRLTPEEIVRFCVTLVVAGSETTTFLIGNLLHAMARDPETTARMRAD RALLNVFVEETMRLDGPPQRLFRIATRDVEVGGKLIRKGEWVALFFGSANRDPDVFADPNVLDLDRPNIR QQLSMGHGLHFCLGASLARLEVMAVLNAVLDRYRTIALTDDPGTKQTASLLTHAYVRLPLHLS

CYP278A3    Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            54% to CYP278A1 Mycobacterium marinum MM2877
            49% to seawater bacterial sequence CYP278B1 JCVI_PEP_1096680833653
            68% to CP000774.1 CYP278A4 Parvibaculum lavamentivorans DS-1 
            REGION: 3745637..3746905 ABS65098.1
            Ectocarpus sctg_1 302460-301204

CYP278A4    Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS65098.1 (protein)
            CDS complement(3745637..3746905) locus_tag="Plav_3499"
            35% to CYP107L1 AF087022  Streptomyces venezuelae
MQEIRKSDRADDLAALVAALPAGDTIASPYALYDRLRPYGPVYG
YRDYPPGTVPDADEAVTAWVLLNYDHVSAAARDHRIFSSRDPLQEQSSAPTLMLVNHD
NPEHDRLRSIVNLAFSRPRIEALDPWVREIVGGMVAGLGDGDTEVMEALAARIPARIM
VGLLGLPEEVVDRFRHWATAFMLSADLDPAEREASNAELVRYFTETVDSLYGALEAGD
PVPDGLIAALLKAEVDGEQLTLDEVIRFCITLVVAGSETTTFLLGNLLHNLAVMPDIR
AQLAANRALIGPFIDESLRHSGPPQRLFRIATQDVEVGGARISKGDWVALFFAAANHD
PAMFPDPEKFDISRPNLNKQLTFGVGIHHCLGSALARMEGRALIEAILDRMDDVSLGA
LPPVPQRASLLNHGFDSLTLRFTAREDETQ

CYP278B1    seawater sequencing J. Craig Venter Institute
            JCVI_PEP_1096680833653 
VAVAEMAIQAARLNSPEVIANPYPYYDQLRAASPVHGYVDLPPGTVPGQDEPKISWAVLRHADVVEA
ARDAQTFSSADPLQAESTAPTLMLVNDDPPRHSKLRAIAHKAFTPRRILEKGPWVAQVAAEILAPCG
GRCFDFMTDVAPVLPTRVMAKVIGVDDAQAPRFRNWATAFMLSADLTPAAREASNREVAAFFVDHVN
RRYALIERGGDPPDDLVTALILEDSDGQRLTRDEVTRFCITLLVAGAET

CYP279A1   Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017241.1 
           CDS complement(293697..294926)
MTVGAAPPSVFDSDLPTLHYHSDETPAQVYPRLREAQRRAAVAI
GPHGPEVLSYHLVRSVLRDPRFQIPPGINLLAQGIDSGPLWDKVANSLLCLEGDAHHR
LRSLCSKAFTPRTVARLHDTMAAVMNELVDRVAAAGRCDVVTDIARPYPVPIICALLG
APREDWRRFSSWADDVFKAFSFTVDLREVEPVVMRAWRELDDYVDEMVARRRHNLTDD
LLSDLIRVGDEGDRLDAAELRMLAGGLLLAGTDTTRNQVAASVQVLCEHPDQWELLRQ
RPELAMRAVEETMRHSPIACGTLRLVVEDAELDGHLFPAGTAVLVNTFAANRDPVVYN
DPDRVDITREAAPPILTFGGGVHYCLGANLARREIAEALNVLANRLRNPRLAGPAPWK
PMVSLSGPTSLPIEFDR

CYP279A2   Mycobacterium marinum 
           No accession number
           Tim Stinear
           Clone name MM0122 
           35% to CYP107AE1, 35% to CYP107L6 new family
           59% to AE017241.1 CYP279A1 Mycobacterium avium subsp. Paratuberculosis

CYP279A3   Mycobacterium vanbaalenii PYR-1 
           ZP_01203523.1, EAS24515.1 
           70% to 279A1 Mycobacterium avium subsp. Paratuberculosis
           55% to 279A5 M. smegmatis
           65% to 297A4 M. vanbaalenii ZP_01203646
           60% to 279A2 M. marinum MM0122
MSGDYVRDSARDHAFPCPYPPHGHTLFSIRKSNRPGSEATMVVSPTVANVFDAGLPTLTYDVFSTPAQVW PDLHDAQRTAPIAIGPMGPEVLSYEMARAVLRDTRFTIPPGINLAAQGITSGPLFDKVMSTLLCLEGSEH QRLRKLVSKAFTPRATERLHDTIVAVVDELVDNIAGARRCDVVADIARPYPIPIICALLGAPREDWRLFS DWTEDVFRAFSFSTDVATVQDDVMRAWNELDDYVDRMVAHRRRHLTDDLLSDLIRAEDDGDRLSTSELQM LAASLLMAGTDTTRNQLAASVQALSERPDQWALLADRPELAMRAVEETMRHSPVVCGAPRIVLDDVEFDG YLFPAGTFVFVNTFAANRDPAVYADADRLDLTREQAPAILTFGGGVHYCLGANLARRELAEALRILAGRL 
SNPRRSGSAPWKPMLGMTGPTVLELEFDA

CYP279A4   Mycobacterium vanbaalenii PYR-1 
           ZP_01203646.1, EAS24638.1 
           66% to CYP279A1 Mycobacterium avium subsp. Paratuberculosis
           51% to 279A5 M. smegmatis
           65% to 279A3 M. vanbaalenii ZP_01203523
           56% to 279A2 M. marinum MM0122
MALPHSRLRTRTRLRPRDHLAVGDVHAAHAAADPDEEDAVTAAATKPSVFDAGLPTLSYDVTDTPQQIYP QFRAAQRIAPIALGPIGPEVLSYEMARTVLRDPRFVIPPGIHLSAHGITSGPLWDRVTRSILNMEGDEHR RLRSLVSRAFTPRATARMHDAIHLVVNELLDAIQDTGRCEFVAEVARPYPIPIICALLGAPREDWQLFSR WAEDIFKIVSFDCDLAEEEPVVLKAWAEFDDYIDGMIADRRRHLSDDLLSDLIRIEDGGDRLDAAELRML AFSVLVAGTDTTRSQLAASVQVLCEHPDQWALLRADSDLAMRTVEETMRHSPSMCSTVRSVTADVEVGEY TFPAGTFILVNTYAANRDHTVYDDPTRFDITREDPPPILTFGGGVHHCLGANLARLELAEALKILSHRFR 
YARRTGPVPWKPLLGLSGPTSLPLEFGP

CYP279A5   Mycobacterium smegmatis
           MSMEG4219 TIGR 
           44% to CYP107E1, 58% to 279A2, 
           57% to 279A1, 55% to 279A3, 51% to 279A4 
           40% to 107AC1, 43% to 107E1
           formerly named CYP107Z1, but this name was given to
           a large subfamily of Streptomyces sequences.
           This new family overlaps slightly with the CYP107 family.
MTRMTVAELTPISYHHATMPAEVHDIIRQARANGPLALGPYGPEILGYEL
VRAVLRDERFEVPRGMFLAAQGITSGPLWERANNTLVGLGGPAHLRLRRL
VARAFIPKAAERLRATCVDIVTELVARCVPAGRCDVVADLAVPYAVPVIC
ALLGAPARDWARFSAWADEIFKMFSWDLGEHAEAVETAWKELDAYVDDMV
VRRRHTLTDDLLSDLIRAEDDGDRLTHHELLMLAGGVLLAGTDTTRNQLA
AAVETLCDHPREWDLLAEHPELAPTFVEELMRFSPATLGTVRIAKEEVEI
AGVTIPAGTLVTVNTAAANRDPQVFADPDRFDVHRRASPPMLGFGGGLHY
CLGVHLARVELAEALCVITAAMRHPHRDGPPPGNR

CYP280A1X  Mycobacterium avium subsp. paratuberculosis
           GenEMBL AE017240.1 
           CDS 48827..50038
           Name changed to CYP191A2
MDFAYDPFDAEVMANPLPYYRILRDHHPVYYMPQWDTFALSRFD
DIWRVLEVNNGTFVASEGTLPPASVLAQHNDGPVDDPPLHPLPFHAMFDADLYGEIRR
THSRPFRPRAVTDLEGRIRTLANERLDELLARGSFDLTQEYGGVVVATIVCELLGIPT
DLAPQVLAAVNAGSLAEPGVGVDTGQARPNYFEFLLPAVQRRRADPSGPPLEVVDGLL
GYQLPDGSALDDLEVATQMLCIFIGGTETVPKIVAHGLWELSRHPDQLAAVRADPQHN
IPVAREEMIRYCAPAQWFARTVRKPFDIHGQTPNPGQRVITLLASANRDEREYPDPDD
FVWDRPIRRSLAFGRGQHFCIGYHLARLEVAVLLQEWLRRVPDYAIRADAATRLPSSF
QWGWNKIPVEV

CYP280A2X  Mycobacterium marinum
           No accession number
           Tim Stinear
           MM0399
           81% to CYP280A1 Mycobacterium avium subsp. paratuberculosis
           29% to CYP123
           Name changed to CYP191A3

CYP280A2X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           98% to 280A2 M. marinum = ortholog
           Name changed to CYP191A3

CYP281A1X  Mycobacterium avium subsp. Paratuberculosis
           AE017229.1 CDS complement(173813..175057)
           Name changed to 188A2

CYP281A2X  Mycobacterium marinum 
           Tim Stinear
           MM4717
           86% to CYP188A2 35% to CYP222A1 Thermobifida fusca
           name changed to 188A3

CYP281A2X  Mycobacterium ulcerans
           No accession number
           Tim Stinear
           97% to 188A3 M. marinum
           36% to CYP243A1 Mycobacterium avium
           formerly 281A2
           name changed to 188A3

CYP282A1   Streptomyces scabies
           SCAB14541
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           NEW FAMILY no obvious matches 34% to 107U1

CYP282B1   Mycobacterium vanbaalenii PYR-1 
           NZ_AAPF01000001.1 
           45% TO CYP282A1 
261164  VTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYA  261343
261344  ECVQILQDWEHFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFS  261490
261491  PARMKALRPEIGVETDRLIDDFIETGSGDLAAVAWRQPGIVFFKYLLGMPVDDVPLCV  261664
261665  ELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMIDVLLSAEIDGEKLAFAD  261844
261845  VVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIRFAGSIHG  262024
262025  IPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHR  262204
262205  CLGSNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKR  262372

CYP283A1   Streptomyces scabies
           SCAB56621
           David Lamb
           Submitted to Nomenclature committee Nov. 10, 2006
           NEW FAMILY 34% to CYP215A1

CYP284A1   Nostoc sp. PCC 7120 (cyanobacteria same as Anabaena)
           GenPept BAB73318                 
           NC_003272 complete genome complement(1615917..1617470)
           24% to 172A1
           formerly 186A1 but that name was already given to
           an M. smegmatis seq (my error).
  1 MLQYITAQID NSSSFPYLVT VLSVTTIAGT FAWRWWKQKK KYKSLQSLPS PPKHWLLGNL
 61 PQVLAAVKQK KLFQLFFDWS QQLGPMYVVW NGSSPVVILS KPKVIEDTIV NGMRDGSLIR
121 SARLRQAWND ISGPILIGET GNEWQWRRKV WNPEFSSSSL AKYLKIINQA CVQVIDTLKE
181 TALPKEVEVD PLFVELTMRV ISSLVLGIPV DRKITTNEGP PLEVLKVYEA MCVVGYRFLR
241 QATGEKIWMK YLPTKNSQDY WASRRYLEEF LTPRVDLALQ MREQSTDFPQ VSPLFRESML
301 VRIAAKEPKY NRQTLIAESV EFLIAGTDTT AHTLSFAVGE LSLNPRVFQK AREIVDQAWQ
361 GQDNINTESF KELAYISAIL KETLRLYSIA SGSTSLEAQR DTVIEGKVIP SGTRISWSML
421 AAGRDPEVYA NPEEFLPERW LDKSKETSSL PMIDFGSGPH RCLGEHLSML EGTMMLALLL
481 RHFDWELVNG RSSLEQLQQN LLIYPSDKMP VRFRLRN

CYP284A2    Nostoc punctiforme
            GenEMBL NZ_AAAY02000016.1 
            complement(17366..18917) gene = Npun4356
            77% to 284A1
            formerly 186A2 but that name was already given to
            an M. smegmatis seq (my error).
MFQQIAAQITFSDSFPYLVTALGITSTAGIFGWRWWKQKNTYKS
LQSFPSPKRHWLLGNIPQVLAAVKEKKFFQLLFDWSQQLGPMYVYWTGFP
18635 VLVLSKPKVIEDTIVNGMRDGSLIRSQRASKAWNDIGGPILLGQNGSEWQYRRKAWNPEF 18456
18455 SSSGLSKYVEIINQACEQIIEKIQSVASPEVQVDPLFVELTMRVISCLVLGIPVDKN 18285
18284 IATNEGQPLDVLKVYEAMSIVGYRFLRVATGEKIWMKYLPTKNSRDYWAARRYLEEFIT 18108
18107 PRVDLALQMREQNQTDLTQVSPLFQESMLVKIAAKEPKYNRETLVAEVIELLIA 17946
17945 GTDTTAHTLSFAIGELALNPRVFHQAQAVVDQVWESQGTINGESLKELNYIRAILKETLR 17766
17765 LYSDDS 17748
      XXXSLXAQR
      DTVIEGTVIPRGTKIYWSMLAAGRDPEVYSHPDEFLPERWLEKGKEN 17579
17578 SQLPMIDFGSGSHRCLGEHLSMLEGTMMLALLVYYFDWELVNGRSSLEQLQQNLLIYPPD 17399
      RMPVRFRLRK* 17366

CYP284A3    Anabaena variabilis ATCC 29413
            YP_324562 
MLQYVTAQMNNSSSFPYLVTIFSFTTIAGTFAWRWWKQKKKYKSLQSLPSPPQHWLLGNLPQVLAAVKQK
KLFQLFFDWSQQLGPMYVVWNGSSPVVILSKPKVIEDTIVNGMRDGSLIRSARLRQAWNDISGPILIGET
GNEWQWRRKVWNPEFSSSSLAKYLKIIHQACEQVIDTLKETAPPKEVEVDPLFVELTMRVISSLVLGIPV
DRTITTNEGPPLEVLKVYEAMCVVGYRFLRQATGEKIWMKYLPTKNSQDYWASRRYLEEFLTPRVDLALQ
MREQKTDFPQVSPLFRESMLVRIAAKEPKYNRQTLIAESVEFLIAGTDTTAHTLSFAVGELSLNPRVFQK
ARDIVDQAWQSQDNINTESFKELAYISAILKETLRLYSVASGSTSLEAQRDTVIEGKVIPSGTRISWSML
AAGRDPEVYAHPEEFLPERWLDKSKETSSLPMIDFGSGPHRCLGEHLSMLEGTMMLALLLRHFDWELVNG
RSSLEQLQQNLLIYPSDKMPVRFRLRN

CYP285A1   Streptomyces tubercidicus strain I-1529
           GenEMBL AY549199
           Istvan Molnar, Syngenta Biotechnology, Inc.
           Jungmann,V., Molnar,I., Hammer,P.E., Hill,D.S., Zirkle,R.,
           Buckel,T.G., Buckel,D., Ligon,J.M. and Pachlatko,J.P.
           Biocatalytic conversion of avermectin to 4'-oxo-avermectin:
           characterization of biocatalytically active bacterial strains and
           of cytochrome p450 monooxygenase enzymes and their genes
           Appl. Environ. Microbiol. 71 (11), 6968-6976 (2005)
           Submitted to nomenclature committee June 2, 2003
           Clone name CypLB
           Low 30% range to other bacterial P450s
           formerly CYP185A1 but that name was already given to
           an M. smegmatis seq (my error)

CYP286A1   Deinococcus radiodurans
           GenPept AAF11281   
           GenEMBL NC_001263 complement(1748793..1750130)
           Gene = DR1723
           25% to CYP120
           formerly CYP187A1 but that name was already given to
           an M. smegmatis seq (my error)
  1 MVPAPPFLGH AAEMGTIKLR PFLTRCYQAY GPVFQLTVPG QKITVLAGPE ANLFAMKEGH
 61 RVLRSLEAWR DNDHEMGSDR SMISLDGAEH RAYRRVEGRA FARSFFAAGL RPALAVLAED
121 LAPFQPGDVL PVATWCKKTI TEQLARMAVG GTVRPYLPDL LHFIQTALQV TVNRQLPPAV
181 LRLPKYRRAK ARIFQMVDDL IEDHRQNPPE KSGRAPDLID DVLADQQVNP ERWEHPDVRL
241 AALGAFIAGM DTAANSLAFV LYRMHLHSEF LPALRAEADA LFRDGPPTAE ALGRSPLLHR
301 FVMETLRVHP IAPALSRTLT EDVEFAGHRI PAGTPVIIGT TVPHGLPELF PDPEHFDPGR
361 FAPGRAEHRQ PGAYAPFGVG SHTCAGSGMA EGLIMLGAAA ALRTLDLSLE PDYVLRQTAK
421 PTPSLDNKLQ LRVNAVRHNP VFLVH

CYP287A1   Deinococcus radiodurans
           GenPept AAF12016, F75270
           GenEMBL NC_001263 2469804..2470949
           Gene = DR2473
           30% to 175A1
           formerly CYP188A1 but that name was already given to
           an M. smegmatis seq (my error)
  1 MLSSLHDLPE PASRPGSGHL QDWAARPLAL IEEGATQALA AGQDLFRLRL GLPAVVGLSP
 61 AWNRRVLTDL NTFVSAGSFS AVVPYLAGGV ILTDAPGHGA RRRALNPGFG KGSVQQLRER
121 MRQASSPVPT GRFNALAWAD ETVRRQLNAA YFASEFDDRL LAAFLAPLRR PFPVPALPRP
181 LLFRRVEQEI RRLAERRLRE GGDDLLSTLA PLPGGLLETR ISLAAAHDTT THALAYAVWE
241 LAKAPQDQTP HTHSAVLKEV LRLYPPGWMG SRRLSRAAEW QGTEIPRGTL ALYSPYLTGR
301 DPTLWERPLD FRPERWEKSP PAWAYLPFGG GERTCLGVHL AQTLILDVLA ELPPLQAHWG
361 NDEPHPGITL GPRGPLVVER R

CYP288A1   Corynebacterium efficiens YS-314
           GenPept BAC17372                 
           35% to CYP116 82% to CYP189A2 NP_599791
           formerly CYP189A1 but that name was already given to
           an M. smegmatis seq (my error)
  1 MIHNMETRCG SYHRATGILT GDDMTSDSTT ALSTAPETTS GGCPYGHGNP DATGTPGTSH
 61 HGYEPFNMTN PFPAYEELRR EEPVMFDERI GYWVVTRYDD IKATFDDWET FSSENAQAPV
121 RKRGPQATKI MEEGGFTAYS GLSARIPPEH TRIRAIAQKA FTPRRYKALE PDIRANVVAR
181 LETMLKQGAP ADIVPALAYD IPTITILTLI GADVSMVDTY KRWSDSRAAM TWGDLSDEEQ
241 IPHAHNLVEY WQECQRMVAD AHANGGDNLT ADLVRAQESG QEITDHEIAS LLYSLLFAGH
301 ETTTTLISNC FRVLLAHRDQ WEALIEDPKK IPAAIDEVLR YSGSIVGWRR KALRDTEIGG
361 QPIKKGDGVL LLMGSANRDE ARFDDGETFD ITRPNAREHL SFGFGIHYCL GNMLAKLQAK
421 ICLEEATRLV PSLELADDQS VEFRENLSFR VPVSVPVTWS N

CYP288A2   Corynebacterium glutamicum ATCC 13032
           GenPept NP_599791  
           35% to CYP116 82% to BAC17372
           formerly CYP189A2 but that name was already given to
           an M. smegmatis seq (my error)
  1 MTSQTSQQST STGGCPFGHT SESTSHHGYQ PFDMHNPFPA YKELRQEEPV MFDERIGYWV
 61 VTKYDDIKTT FDDWETFSSE NAQAPVRKRG PQATQIMTDG GFTAYSGLSA RIPPEHTRIR
121 AIAQKAFTPR RYKALEPDIR AMVIDRVEKM LANDQHVGDM VSDLAYDIPT ITILTLIGAD
181 ISMVDTYKRW SDSRAAMTWG DLSDEEQIPH AHNLVEYWQE CQRMVADAHA HGGDNLTADL
241 VRAQQEGQEI TDHEIASLLY SLLFAGHETT TTLISNCFRV LLDHPEQWQA ILENPKLIPA
301 AVDEVLRYSG SIVGWRRKAL KDTEIGGVAI KEGDGVLLLM GSANRDEARF ENGEEFDISR
361 ANAREHLSFG FGIHYCLGNM LAKLQAKICL EEVTRLVPSL HLVADKAIGF RENLSFRVPT
421 SVPVTWNA

CYP289A1   Brucella melitensis 16M
           GenPept AAL54121    
           PUTATIVE CYTOCHROME P450 YJIB
           31% to CYP145
           formerly CYP190A1 but that name was already given to
           an M. smegmatis seq (my error)
  1 MRAGGIMTSP TERPKQDWDP RSEAVLSDQI GAYDAMRHQC PVAHSDYLGW SLFSYDDVVR
 61 VLDDHETFSS VVSAHLSVPS GMDPPQHTAF RQLVERYFEP ERIKAFEPIC REISKKLVCE
121 LPRDAEIDLV TQFAQLYAVR IQCAFLGWPD SLQGPLLDWV HKNHAATLAR DTKAMAAIAL
181 EFDEYIRDLL DERRKLGADA PDDVTTRLLR DRIDRRNLTH EEIVSILRNW TVGELGTITA
241 CVGILCHYLA KSQQTQALMR GGPDLLPAAI DEILRLHAPL ISNRRVTTRA VVVGGREIPA
301 GEKITLMWAS ANRDEAVFDK PDELRLNRDP ALNLLYGRGI HVCPGAELAR AGLRILMEEL
361 LGQTRKLDLV PGSVPALAVY PASGFSRLPA RIS

CYP290A1   Caulobacter crescentus CB15
           GenPept AAK22930  
           NC_002696 complete genome 1051211..1052545
           34% to CYP180A1
           formerly CYP191A1 but that name was already given to
           an M. smegmatis seq (my error)
  1 MDLISQTVVD GKAGPGAPPT YPTLKDVDLA DIFRFTKGQP WADFARMRQE APVMWHPEPM
 61 GGPGFWALTR YEDVHRVNGD PETFSSQRGG ILMSMGAPEK RHALLFRASM DTMINMDAPH
121 HLQLRREHMP YFTPSYLRGL TERVKGEVTR LLDEMEPLLA NGAEIDMVEH FSSVLPLFTL
181 CEILGVPPED RPKFLTWMHY LERAQDLAVK QANAPMQPTL ELMQFVMDFN NNVEEMFEYG
241 RTMLHKRRED PKEDLMTAIA RAQLDGAVLP DEYLDGSWLL IVFAGNDTTR NTLSGAMRLL
301 TEFPDQKQKL IADPSLLGGA VDEFIRMVSP VVYMRRTATR DVEVNGQLIR EGEKAIMYYG
361 AANRDPAMFE NPDQLDVTRA NAGKHIAFGY GPHTCIGKRV AQIQLEEAYR QILARFPDLN
421 WTGNIEIAPN NFVHAISKLG VKRG

CYP290B1    Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            46% to CYP290A1 Caulobacter crescentus CB15 GenPept AAK22930
            75% to seawater bacterial sequence CYP290B3 JCVI_PEP_1096682145269
            67% to CYP290B2 CP000449.1 Maricaulis maris MCS10 
            Ectocarpus sctg_1 3343594-3342116

CYP290B2    Maricaulis maris MCS10, synonymous with Caulobacter halobacteroides
            CP000449.1
            67% to CYP290B1
MQLVSDVILEDRPQTEPGFGATYPGFDDFKLWDPAAWTSGHPHD
FFRKMREQAPVMWQSADKSKAGYWSVTRYDDIKTVELAPEIYSSERGSINMFVMPRKE
WKPKKLIPAAFNSIINLDQPHHMQMRIQQKDFFIPRFVSELQERVDAKIDDLLDEMER
RGPVVDFVKLFSQELPLFTLCEMLGVDEADRPKIIEWMHYLELANQYFVNPWSLLSRR
PWFPIKFYHHVNAMFAYGERVMAERRANPRRDLMTAIANTEMAGKPLPQEYLDGSWLL
IIFAGNDTSRNSLSGTIRLMTQFEDQREAILSDPSLIPAMTNEALRMISPVQHMRRTA
MEDTELNGQRIARDEKVVLWYPAANRDPSVFPDPDRFDMTRENGDKHLAFGHGAHKCL
GSRIAQMQLQSAFRKIFERFPKIAWTGRQTIAPNTLVHAISSLEVNLYGRDGERPRPV
QERWP

CYP290B3    seawater sequencing J Craig Venter Institute
            JCVI_PEP_1096682145269, 
            70% to CYP290B1 
MMVGDRKLWKPEKLAPAAFNSLINLDAPAHMEMRMQQSEFFFPAYIETLRDKVEAKIDAMLDELERQGPVVDFA
KLFSEELPLFTLCEMLGIDEEDRPRIKLWMHHLELAGQFLANPWQTFLSEPMFPFRFNKVVQEMFAFGERIMKDRRANPR
DDLLTVIAQSKLEGELLPQEYLDGSWLLIIFAGNDTSRNSLSGTIRLMTEFPTQRTLVLDDPSLIPQMSEEALRMVSPVI
HMRRTAVEDTEINGQPIAKDEKVVLWYGAANRDPDIFPDPDTFNLHRDNVEKHLAFGHGVHKCLGSRIAKMQLRLAFEQI
FKRFPNIYWTGKQKIAPNSLVHAISSLKVNLYGPDARRPTRIAANK*

CYP291A1   Mycobacterium vanbaalenii PYR-1 
           ZP_01204524.1, EAS25516.1 
MSRLSNPLHSPAFYAGDPFPVYRELRATDPVCWNDEHEFWALLKYEDIRYVSTNPALFSSARGVTVPDPA LENPVMEGSLIFTDPPRHRQLRKLINSGFTRRQVAILEPKLRAFARAALDAIDPSATEFAEQVAAPLPTR MIAELLGAPDEDWEQFRTWSDATVGMDDPDVELDTFAAMGELYQYFEAQIARRRDGTLRDSDDLLSVLVA AEVDGVRLTDQDLLQFCLLLLVAGNETTRNLVALGTLALIENPDQFRLLRQRRDLVPTAVEEMLRYASPV ANMTRCATRDVDIRGRSIRAGQYVTMLYGSANRDKDVFGPTSEQFDITRNPNPHLAFGCGEHSCLGAQLA RLEARVLFEELLNRFDHIELDGDVLRMQATMVPGVRQMPVRLSATAAEPRETGTAAVSV

CYP291A2   Mycobacterium flavescens PYR-GCK
           ZP_01195006.1, EAS08752.1 
           85% to CYP291A1
MGRRTDLESP CGALHPSARI HPARTSPARQ RHRRRLGRRR ALGVPARPAR HPDRPAAHVT
PAVISAIPPV ASLAQKEIAL PPPLHSPAFY AGDPFPAYRE LRATDPVTWN EEHGFWALLK
YEDIRYVSTN PALFSSARGI TVPDPAIENP VMEGSLIFTD PPRHRRLRKL INSGFTRRQV
AILEPKLRAF ARTALDAIDP AGGTEFAERI AAPLPTRMIA ELLGAPDEDW EQFRRWSDAA
VGMDDPDVEL DTFTAMGELY QYFEKLIALR RNGALRDSDD LLSVLVAAEV DGVRLSDQDL
LQFCLLLLVA GNETTRNLIA LGTLALIEHP QQFRLLREHP ELIPTAVEEF LRYTSPVANM
TRCATRDVEM RGRLIREGQY VTMLYGSANR DEDIFGPTSE QLDVTRNPNP HLAFGCGEHS
CLGAQLARLE ARVLFEELLA RFEHIEPAGE VLRMQATMVP GVRAMPVRLR AATDPRRAKARAG

CYP291A3   Mycobacterium avium subsp. Paratuberculosis
           NP_961518.1, AAS04901.1 
           69% to CYP291A1 = L76374
MQTHPPLRSP SFPLHSPDFY AGNPYPAYRE LRATAPVCWN DVTNFWALLK YEDIRFVSSN
PALFTSTRGI TIPDPQLPNP VQQGSLIFTD PPRHRQLRKL INSGFTRRRV SVLEPKIRKI
VRGILDGIER GAVHEFAEQI AAPLPTRMIA ELIGAPPDDW EQFRAWSDAA TGTADPEIEL
DPAVAAGQLY EYFQRLIAAR RARPRADLLS VLAEAEIDEH RLTDEDLLNF AFLLLVAGNE
TTRNLIALGT LALIAHPDQY RLLVEEPARI PLAVEEMLRW NSPVVHMART ATADVEIRGQ
RIRAGEVVVM LYGSANRDED VFGPDSEEFD VTRHPNPHIA FGCGEHSCVG AQLARLEATV
FFEELLRRYP RIELVGEVDR MRATMVPGVK RMPVRMGA

CYP292A1   Mycobacterium vanbaalenii PYR-1 
           ZP_01203641.1, EAS24633.1 
MTRTPERHAENWDLRHPDFNDNDFLYDVYAVMRAKSPFARTDNPFLSATPAGAWVAVRYAECVQILQDWE HFSSNPTPEGAEQLAGDLVITLDPPRQQKFRKVLNPYFSPARMKALRPEIGVETDRLIDDFIETGSGDLA AVAWRQPGIVFFKYLLGMPVDDVPLCVELTDTALNGATEQDRMAAWGGLYQHLHDAVTARRGQPPRDDMI DVLLSAEIDGEKLAFADVVSNAMLLVQAGLETTASAMSFAYHYLATNPAERDRLIDDPDLLTRAVEEFIR FAGSIHGIPRTVAREVELSGCTFSPGESVIVNYAAANRDEQEFPDAHRCILDRRDNRHLGFGAGVHRCLG SNLARLEFQVGLERVLTRMPDFALSPTSKAEFHGNSVTRGFRSVPVVFTPGKRVTA

CYP292A2   Mycobacterium flavescens PYR-GCK
           ZP_01190587.1, EAS12881.1 
           88% to CYP292A1
MSPTVEQHAE NWDLRHADFN DPDFLYDVYT VMRGNSPFAR TDNPFLSATP SGAWVAVRYA
ECVQILQDWE HFSSSPTPEG AEQLAGDLVI TLDPPRQQKF RKVLNPYFSP ARMKALRHEI
AAETDDLIDV FIESGSGDLA EVAWRQPGIV FFKYLLGMPV DDVPLCVELT DTALNGATEE
ARMGAWGGLY QHLHDAVTAR TAEPPRDDMI DVLLSAEIDG EKLAFGDVVS NAMLLVQAGL
ETTASAMSFA YHYLATHPAE RDRLIAEPDL LARAVEEFIR FAGSIHGIPR TVAKEVELSG
CTFSPGESVI VNYASANRDE EQFPEADRCI LDRRENRHLG FGAGVHRCLG SNLARLEFQV
GLERVLTRMP DFTLTAGAEA KFHGNSVTRG FRSVPVTFTP AARTR

CYP293A1    Saccharopolyspora erythraea NRRL23338
            SACE_1376, se: 1521656,1522816 (-) STRAND
            61% to CYP293A2, 39% to CYP279A3 S. vanbaalenii, 36% to CYP151A1
VDVFDRNFGYDSDTLAAARERHWYARIPNGLMVLGHEEVNDLLRDHRLVSDGKRYLEMHG
VTSGPLYDWFVPMILHREGQDHARLRSVVRRTFTPRVIEGLRPYMRETVGRIADGIAETG
ECEFVETLANPFPVMVMGRLLGVPPQDHELFHGWSTDVGLVFSLAYGGDVRERVERAVSE
LGDYFDGLIERRRAEPADDLISSMIAAQTEEEVISGEELRNLLVALVSAGHDTTRHQFGS
AMLTLCRNPEQWTAFRDDPDRAVEEILRWCPAAPVLFRFAQEDIAYRDTTIPAGTFVMLC
VHTANRDPKRFDRAEVFDTTASRQTPHLTLSAGPHFCLGAAAARAELSEAFTVLSTRFGA
PRIAGEVTWRNPVGIYGPETLPVRFV

CYP293A2    Saccharopolyspora erythraea NRRL23338
            SACE_3308, se: 3655951,3657162 (-) STRAND
            61% to CYP293A1
MPTSIESASQAPFLDVTDPGFTFEAPEVARARERHWYARTPVGPIVLRHAEVQELIRDPR
LAQDGARYLAMHGITSGPVHDWFVPLILHRNGVDHLRLRRVVQKSFTPRVVNNLRPFMRA
TAERLAERIAAEGACDFVEMFADPYPVAVMCELLGVPPQDYELFHRCSTDIGLVFSLSQG
DGVRERVERGVVELYAYVDSLIARRRAAPTGDLVSRMISAHEDDARLSSEELRNLVVALV
FAGHDTTRHQLGRAMVALCAHSEQWTALREEPQRAGAIVEELLRLFPTAPVIFRFATEDL
EYQDTAIPAGTFVMLCVQSAHRDVRAFGPDVESLDPAAERGAAQMVFGGGPHFCLGAATA
RAELAEALPVLARRLGAPAPAGPVAWRHPIGIYGPESLPLRFG 

CYP294A1    Saccharopolyspora erythraea NRRL23338
            SACE_2631, se: 2876305,2877468 (-) STRAND
            41% to CYP107N1
MEQASTGQLGPLPEFLRQATDEVERIVAPSGDKVLLVRGYALGRQVLTDKRFSRAAAVQP
DAPRFNDAQPVPDSMMSMDGAKHARLRRVVAGTFTTGRVSAMAPAVERLVDEHLNRVADI
GPGADLVEELAAPLSLSVLCSLLGIPLDDSARFREWVEVLFDITASTPREKARHRLELIG
YMTDTIEQKLQRQDDDLLTTLIRAHTQGKMSRPELLTLGLTLLMAGYETTAGQIGLSVLS
LLSDRETHDELRAHPELLPDAVEEFLRLTPATPLSFPRVAVEPVELNGVTIQAGEAVVVS
LLHGNRDTEVFAEPGQLMLRSRDAVHLTFGHGVHRCLGAPLAKLQVQLVLGRLLERFPAL
RLTPGPDSVVWKDGLATRGLSRLRVEW

CYP295A1    Saccharopolyspora erythraea NRRL23338
            SACE_2082, se: 3065572,3066867 (-) STRAND
            26% to CYP171A1
MLGTRTVRPPGPKGRWLVGNTLDYDRDRMAFLVRCRQEYGDVFSFDERTIVVLDPGLVHD
LLTRTNDDFHSESVPLATRIDPERAAADAQAWMTARRKGWHGLNRAVAQAHAGRLRLLFE
QTLAETRGETVDVLPVMERFAGLATADFCLGADADGMAEILTENVRAIEPLGGSSQLFPA
WWPSRHIRRFLRAREGTLNAVTERIHRRRDKPPADHPQDLLDVLLAAGEPELTEQQVQLL
LRGIMLAAFGVPATALTWLVWTLASRPDLHRRVAEEAAAWPGEEAPPLSALPQTEAVVKE
VLRLWPPTWLIGRTARRGTTLGEWQLRPDDHVMFSPYLMHRDPRWWTDPDELTPDRWLDP
ARTPKRHTYIPFGAGPRVCVGTQLGMIQLCLAAHWLTRNHEIRPTTETCAPKFHDLLLPQ
GFRARFTPRTP 

CYP296A1    Saccharopolyspora erythraea NRRL23338
            SACE_4818, se: 5381779,5382957 (+) STRAND
            38% to CYP107X1
MLEQDVLDEVTNPFPGLAALQEQTPAVRVRTPDGPPAWLVTRYADVRDLLRDDTRLSVDP
DHGAGEDYAGFELPPQLRPHLLAVDAAQHDRLRELISSPFTGTGLHRTVEVVEAEAHRLV
AALAPDQPVDLVAELAFPLALTAVRAVLPLPDPAHQAFAEWAHDALLAPRRQEDGAEVRA
RDTLGRMAEIIQTATTVPGDGLLGELQAAYHHGRLSAHELAAQVFYLLFVPTEPLVDAFG
VVLLRLLAGTRHRAVLRDSPAARHVAVAEALRFDTPQGLAAPRFALVDLDIDGVRVRAGQ
TLLLSLAAANRDPRQFDDPDELVLTRSPNPHLALGRGDHACPATALSYQLLSSSVAALLS
RYPSTTVVPEKTQWRGNFRHRGPASVWADLKP 

CYP297A1    Saccharopolyspora erythraea NRRL23338
            SACE_5461, se: 6115384,6116697 (+) STRAND) 
            38% to 102C1 (I-helix to end)
MAGPVLSSSDIPGPPPSAGGHNLRDIAEAGGLPGFQVRLHRTYGEIAHFAMPNAQVVSVA
SPEVLESTLDLPECPMELAPFLTPLADAANVLLSGEQDRARWRRTVIPALSCPHRAESDH
PRFIDIIEESAQRWSSTGEPVALERELDTLALRLMCTSVLGSTPGQAAIVERVTDAFERL
PEFFLGQVYGVRTTSQEPAVDSALTTLRDVVTFLVDEVAPSDLISAARRAGQSSKDLVNT
LLAILIGAHRTTGTVVSHALRQLMRHRDVAKRLRAELKTVLGGKAAPAFHELPCLRYLRR
TLNESVRLASPVPGIARRAPDGIALGAYRIPAGTVVHYAIRAVHMNPRVWPRPDEFDPDR
FDTAPQNSRPAMAFVPFGIGRNDCPGALVAMEHALLMLAVLAHRFRFESRTAGKQGSRFS
LGGPCADPVRVRPRRSR

CYP298A1    Saccharopolyspora erythraea NRRL23338
            SACE_6112, se: 6855037,6856212 (+) STRAND
            34% to 107X1
MSVPTAVGAACPGEVFDPLSPSMLADPYLVYERLRTEAPVHWHEHLRAWVLTRHEDCVGV
LRRPEVFGSDPRKLAKPIPESVISLQTMDPPEHSAVRHHFLAKLRRQDLDAWSARVRRIA
VELLSNAGPDPFDFVAEVAEPLALHSMCSLCGVPYPEDDERFRTASRTMVLGMDAGLEPA
RREPALAARGVLNEIIEDWIARAPRESLISGLDEVSGIERGYLVNSARAVFDAGYSTTGN
MLGNIVKWLLGPGGVRETAPLGGLDSRAVEELGRIEGVVQAVSRHCLAAVEIGGRTLRRG
DVVIVMLAAANHDPKVFPDPRRADFSRESGPHLVFGRGVHSCLGGHVAGRVALALLHALA
DGFERIEPAGPHRQRPTATQRGLDHLPIRLS

CYP299A1   Natronomonas pharaonis DSM 2160 (Euryarchaeota; Halobacteria)
           CAI49361 GenPept, CR936257.1:1230684..1232030 genomic
           YP_326920 GenPept, NC_007426.1:1230684..1232030
  1 MSTRLPEPPE AGLLNALRFG TDTFRFLEGI QARFDDGTSV SIPGRPPLVV LTGPDLVGEA
 61 LDRPEDFPRV PAQDAVTMIA ENGLVQSEGA LWSQQRSVMA PSFSGEQVTA YANTTGRRIE
121 ARADQWAAAG ARTTDLHREM TSLTVRVASE ILLGEDIGTE RADQFHEWMQ VAGEEFEFGI
181 ETVLPDWVPT PTSGEFEQAA AGIRELSEQL IERRRESLAA GERPDASDML TMLIRAEDNP
241 DIDYPENQIR DEVATFLIAG HETTALSLTY TLCLLSWHPE ARRRVRQEAD EALGDGPPTH
301 DDLAELTYTR RVYDEALRLY PPAWGVFRQA NGDVTLGQYT IPDGSAVIMP LWSIHRDGSY
361 FEQPDTFDPD RWERRTPRAV DAYRPFSSGP HACIGRGFAL AGSTLVLARL VRDFDIDVPE
421 SALDDLRLTP TLRPADGVEA TIQPVGGR

CYP1001A1   uncultured haloarchaeon FLAS10H9 (Euryarchaeota; Halobacteria)
            ABT17365 GenPept, EF558547.1 4383-5705 genomic
            58% to YP_135740 Haloarcula marismortui
  1 MTRAPHTPPG PPVVGNVPRF ADDPLRFLVG VQEAYGGQYP VVRLEPAGGQ RIVVILDAAL
 61 VHEILADRER FVRPRAGPEA SRREGLLSSR GPLWERQRSV IQPELVGGQL AAYADIAARS
121 VEEMLDRWPE NGEIDLVAEL SMLTMQVIAR SLLGRDATRE QARTVYEALD TFAEEFEFGA
181 DALLLPDALQ SGPSAAFERA DADLEAVARD FVDWQREHED PPDSMLTALI EAERDGVELS
241 EDELIDQTVL FLTAGQETTA LTIAYAFHHL SRSPDVRAGV TEEATGVLDG AAPSWEHLSG
301 FDLTERVVRE TLRLTPAAWN VTREVRGPTT LGGTRFETDD LVLLPTYAHQ REDRVWGDGD
361 AFRPARWTDE VSRSHDSYFP FGSGPRVCIG RQVALTEAQF TLAHTLQQYE VDVHGDELAF
421 EPAITLRPAD GLRATVTERE

CYP1001A2   Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)
            YP_135740, AAV46034 GenPept, NC_006396.1:957294..958619 genomic
            58% to ABT17365 uncultured haloarchaeon FLAS10H9
  1 MERTAHTPPG LPVVGNLPRL ARDPLRFLTG MQDAYANQYP LVRVDPQVGQ SVTVVLDPDI
 61 AHEVLADRDR FRRPNVGAQE QRRQGLVSSD GALWEQQRSV LDPEFVGGRL ADYAEIAGDT
121 LEETLTAWPE SGRVDLFEEL SILTMRVITR SLFSQDTDRE RGETVHEALA ALNDEFDASV
181 FDLVLPEQLQ SGVSAEFEEA DAVLDSVATE FVDWHLNHED PPRDVITALI DAKADPDIEL
241 SENELIDQTV LFMTGGQETT ALTIAYAFYW LSQNPAAKER VRAEAQDVLD GGQPGWADLS
301 DLTYTERVVR ETLRLTPAVW SVSREAREPV TLAGTDLDAG EFVMLPIYAH HRDSRVWSDP
361 LTFDPDRWAG SASRGDSAYY PFGSGPRVCI GRQVALTEAQ FALAHVLQHY DVQVTADELD
421 LQPSVTLRPS GPMEAEISAL E

CYP1002A1   Halorubrum lacusprofundi ATCC 49239 (Euryarchaeota; Halobacteria)
            ZP_02015811, EDN49875.1 GenPept, NZ_ABEB01000002.1 
            complement(438766..440292) genomic
  1 MCNPITRSDD DRARQSGGSE RTDTADADVD VADAPPPPDP GGLPVLGNVH ELASDALGFY
 61 ERRSAEYGGI VRYDVFGTES YLVTDPGAIG RILVEDHDRF VKGEMPREQL GGLLGDGLFL
121 AEGEAWREQR TAIRSAFFRE RVAAYGDSMV EHAREAVDSW GDGAVVDVHA ASTEYAFAVL
181 AESLLGSDIE GERETVRAAA EAITDRFDMS RPTSFLPEWL PTPANRRYRR RLGALRATIR
241 DLVTERRAAG PPADPSAADD LLGTLVAAAK LGALDDEELV DNAVTFLFAG HETSALGLTY
301 ALYCLARRPA FQDRIRSEIA PLHGDPTPAD LRECPALTAA VDEALRLYPP VHSFFREPTE
361 PIALGEYRIP SGVVLTLAPW SVHRDGRWWN APETYRPERW LRETEDGGVV HGDDRSGPAV
421 GEHPEHAFFP FGGGPRHCIG MRFARQELRL AVATILRRVR LEPVTEELSL QASANTRPDG
481 PVHVRILTRD EPSDPESLDQ DEPSKTSW

CYP1002B1   Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
            ZP_04000149, ABTX01000002.1 262288-260948
            49% to CYP1002A1 Halorubrum lacusprofundi (Euryarchaeota; 
            Halobacteria)
  1 MSTEGGYPPG DGGLPVVGNT VELSRDILEF YEGLRNEYGR IASYRVFGTD ACMVADPEAI
 61 RQILLEDHDA YEKGDVLTRS LGDAMGDGLF LSAGEQWHRQ RTRMQPAFYR ERLDTYVPAM
121 RDTASQSLDD WHDEAVIEVN DAMTAMTIDV LGRTLFGVDV ADEPVVTDAS DAILARFDTN
181 RFWSFLPDSV PTPTNRRYRR EIERLREFVD GLADQRRRRP REERGDDLLS ILVGFVESGD
241 LTMSEFRDNL ITFLFAGHET TALGLTYTVL CLARNPDEQE RIRAEVDSVC DGSVTAADLP
301 ELEQTGRAID EALRLYPPVY LFFRETARDV KLAGYRIPNG TTLVLSPWVV HRDSAWWDDP
361 QTYRPDRFAG ESDRPEYAYF PFGGGPRHCI GMRFARMEMK TVIASILRRY EFELVSDPDP
421 ELIASSNLKP AEDIEIRVSE RASTTSN

CYP1002C1   Halorhabdus utahensis DSM 12940 (Archaea; Euryarchaeota)
            ZP_03870570
            46% to CYP1002B1 Halogeometricum borinquense
  1 MAETQGSSTE RGEQPSETPP GPGGLPLLGN TLDLYRDPWA LYEELESYGD VVHYTAGGND
 61 FNVVLDPTLV EQVLLTDHDA YGKWALGDVG GGIGSEGLVL TEGEQWQRQR RVIQDAFTMD
121 RIRAYGDAMG QYAAEAVEAW DDGEEIALNE AFSRLTLRIL AHSLFDLDID AEAGTVAEFT
181 RTVNDRMDVD NLTAFVPLWV PLPRNRRFKR RVAAFESFVE ELIEQRRADA TERDDLLSLL
241 LAHEGDGLTE TEIRDQMTTF LFAGHETTSL ALTYACMALA THPGPRERLN REHERVLDGG
301 IPSLAQLPQL EATERAIKEA LRLYPPVYVL FREANRDVEL GGYRVPSGQK VTVPQFWIHR
361 KEAFYDDPDE FDPSRWTDGF EDELHDYAYF PFGGGPRHCI GMRFAMQELK TVLPTVLQRV
421 DFELLSDPDP DFSMGATLRP AEDVRVRVRK RD

CYP1003A1   Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)
            YP_137709, AAV48003 GenPept, NC_006396.1:2929400..2930776 genomic
  1 MDTQQAIRET PEPVTPGDRP PRLGRVPFVD NTAAMLRDPL GFYDRAGAHE ADMVGYSVAG
 61 TTGCFVCHPD LVEQVLVTDA DVYEKGQLLQ DTLGQFIGEG LFLLEGEEWQ QQRTALQPAF
121 YRERIAAYGD TMTEFADRAA AGWSDGQRID VLPHMQSLTL NILGKTLLDV DIETTADALE
181 PLLDALRTRL DPRSLSAYLP LWVPTATNRA VTNSLAEFQS TLDDVIAARQ REDEHAREAR
241 DDVLSLLLSL DDETMDRERL GHQLLTFLVA GHDTTALTLT YAWFLLANNP KRQQRLHDEL
301 DATLGERQPT PEDLFELPYL DAVLNEVLRL YPPAFTVFRQ PTEPVTLGGY ELSTDAQLTL
361 PQWLVHRDDR WYDAPDAFRP ERWDDDLEAS LPDYAYYPFG GGPRHCIGMR FARMEAKLAL
421 ATIAQQYAVE AVTEPPLSLA MQITLSPTAP VEVRLRER

CYP1004A1    Salinispora tropica (marine actinomycete)
             Strop_2825 complement(3240153..3241445)
             45% to Strop_2829
             39% TO CYP107AQ1 Saccharopolyspora erythraea
             36% to CYP107P1 AL049754.1 Streptomyces coelicolor
MSTFSLERVACDRMLGLAVRGRLADSLLMRANTARPHLSAAFLATKDDPYPAYAELRARG
PLTRAELGQWLVTGHGAVSALLRDGRLESRMPAEYTRLTLGDSPGVDFLHRIVLTRTPPE
HTRLRRFIGRALGTPVVRRLHDRIAAATDALLEPALDRGRLDVVTELAVPLPVGVVCDLI
GIPTGDRPAVLTRVTALAKVFDAANLSPADLADINTALPWLHDYFGDLLAVRRAGSGGPT
LTEMYWEESASDRLAVADFVDNMLFLFHAGFETTMGLVSNGVAALLNNPEQLGRLRADPA
LVPSAVEEFLRYDAPIQNVIRVARKPVEVAGQKIRAGRTVLLLLGAANRDEEVFADAERL
DVGRDPNPHLGFGGGLHHCVGTALARLMAVVVFERLVDRVTVLGPAAPAVRRRHASLRSY
DHLPLAVAAR

CYP1004B1    Salinispora tropica (marine actinomycete)
             Strop_2829 3244612..3245814
             45% to Strop_2825
             39% to CYP107P1 AL049754.1 Streptomyces coelicolor
MTTSALAPRFDALDPNVVEDPYPEYARLRAAGPLCRLGPGSWGVTRFADVTNLQHDPRLG
SEFPAGYHEISVGDGPASAFFQRVMLYRDPPDHIRLRRLMSGAFTPAVVRRLRSHIEDLV
DELLAPALAAGRMDLVPELAYPLPVRVVCRLMGIPPESTEDVRHHATNIGRAFTAVVPEQ
ARTEADEAVSWLREHLGALLEQRRSHRGDDLLSRLLDAEESGDNLSADEIVDNTVFSFFA
GFETTVHMITTGTAALLAHPDQLARLRADPSLVTTAVDEFLRWDAPIQGTARYVREPIEI
GGRTIRRGRVLVLMIGSANHDERRFAQPDRLDVGRQDNPHVAFGGGAHLCLGAFLARMEG
AVVFDRLARLAVLEPDGPTVREPNTPFRAYASVPVRIGDR

CYP1005A1    Salinispora tropica (marine actinomycete)
             Strop_1572 complement(1785780..1786949)
             29% to CYP116B2 Rhodococcus sp.
             53% to CP000481.1 Acidothermus cellulolyticus 11B
MSAVLFRSWTKTAGTHWPAITRVADQQGTEHLVVTQHALVRQVLTDQLTYRPDNALDAVT
PIPVAALRVLAGHRFRLPPTLANNGGVSHPAIRALVADALHPAKVAAQRPWLTGLVAERV
AAIRRTLDSGGSTDLHAELNADLPLLVLARLVELPDAPVSAVKQFARAALELFWAPLDAD
RQLALADEVGRFHQVLREFADTGGGLAAALRATGHPPDVLVGALFFLLVAGQETTSQFLT
LLLHRLADEPTVRAALRADSVSVADVVEEGLRLEPPIVTWRRVAAVDSTLGGSTVAAGTS
VLLWLARAGRDPAVVPAPDEFRPGQRGSRRHLAFGAGAHRCLGDQLARMEAAVVVEQVTP
LLDGVTVVRPPWYPDNLTFRMPDAFVVRR

CYP1005A2    Acidothermus cellulolyticus 11B (Actinobacteria)
             GenEMBL CP000481 REGION: 1144006..1145259
             53% to CYP3005A1
MSGATDAAERETEILYRDWYATDPRRPVIRVGRHWLVSSRALVK
AVLLDQETFAADNTLDAETPMSVAALRILAGHRFRLPHTLANNSGPSHAGWRRLLAPY
FSPSAIERHRAYVDRVAEQLVAEAAAVLARDGVVDLHAAVSQPLPLVVLDRIIGLPPD
DIATVKRFAAAALELFWAPLTPERQRVLADQVGAYHARLRRFAQTAGGLGAELRDHAQ
RTGLSDDDVVGVLFFLVVAGQETTSQFLTALFARLLAEPAVLAGLRRGRIAVADVVAE
GLRLLTPVVTWRRVATRDVVLGGTTIPRGGSIVLRLAAAGRDPDEVAEPEHFLPGQRG
SRRHLAFGAGAHRCLGAQLATMEAEIVVTRIADLLAEAEVVRAPRHPLNLSFRMPDAL
VVRSAAVSAGVAPAGGSCRGRSRSM

CYP1006A1   Natrialba asiatica (Euryarchaeota; Halobacteria)
            BZ895753.1 GSS sequence
            42% TO CYP205A1 Chloroflexus aurantiacus
WRYAEDVARALFGVDIDDDVETVGSALDEFMLATESLSHMMLPPRVPTPSRRRIQRARES
LDAVVYRMIEERRANPTDRDVISKLLEVTDEDGTKLSDEQIRDEVVTLLLAGHETTALSL
TFTAYLLATNPAAEERLVDELDDVLGGETPTMADLDDLTYTEQVVEESMRLYPPVPGIVR
EPAKPDIIGGYEIEPGATVRMHQWGGPPRP

CYP1007A1   Lyngbya sp. PCC 810
            ZP_01623228 6
MLASAADQAEFIDLGVKKMTTIANQKAWTIPGPSPLPLVGRIVNTINFAKDSIGYSSELFKTYGKVASIV
AGGGTNLYSAASDCPGTVIAYGPEIVRQVATQSHIYHKAPLSGILYRYKDVSERTKPLKNYGVGLFGVND
ETHLKQRKLMMPAFHHQQLRSYRDDMVAITQSELEQIKVNEPCEINQLMKRLTLRIATQSLFGEDVIEKD
HSAGNLLQEIISIQISPFTRLLPLDLPGFSFHRYLDLLSLFETQMKGIIAEKKAKTTPDSDVLSMLVKAR
YEDTGHLLTEDELIAHTGVLFLAGHETTANALTWILLLLSQHPQVCSDLFDELDSTLHGNSPSVEQLQKL
PLLERVIKESLRVITSVPWNGRVTSQTTELGGYVLPKGTEVFVSIYHTHHLPDIYPDPEAFNPQRWESIN
PSVYEYNPFSAGPRLCLGAAFAMMEIKIVLAMLLQRFRWEYLPVQKIDRNGFISIKPKFGMQMKVCSQDR
EFMHGVGSVEGNVREMVKLPS

CYP1008A1   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            56% to seawater bacterial sequence CYP1008A2 
            Ectocarpus sctg_1 2052003-2053223

CYP1008A2   seawater sequencing J Craig Venter Institute
            JCVI_PEP_1096696260773 
            56% to CYP1008A1
MMSETNQAAIGDWVGADFFDPSFRDDPYPKLAHLRENDPVNLTPVGTWRISRYEDVKAVFNDAPTSMTDKLGDSPNFDP
LDTKGSFLEFVLNKDGDAHRRLRMLVQKSFGQKTVRLMEEEVAKTVAAAFDKAQADGGMDVVPALAHEVPSRMICQIMGV
PMQDRQIFNEWTAARTNAFFAKFLPPDVQERTRNAGAAMEDYFRALIAERKRDLGDDLLSSMIMASEGGDKFTDDELIIQ
AIGVIVAGYETTIGLLGNGTRAFVEHPDQLAKLRNNPELVSNATDECLRYDTPILFNWRVLEEPYELSGVTLPAEAVIWQ
LLGAANRDPARFADPDQFDIEREDVAHQSFGGG

CYP1009A1   Ectocarpus bacterium
            Genoscope Ectocarpus siliculosus brown algae project
            A bacterial genome was found with the Ectocarpus DNA
            58% to partial Metagenome sequence AAFZ01017524.1 CYP1009A2
            Ectocarpus sctg_1 2103615-2102353

CYP1009A2   Metagenome sequence, 
            AAFZ01017524.1
            microbial mat from gray whale carcass in the Pacific Ocean
34   NQMDALDNTYRALVHRAFSRRTVEERRPRIVEVVNGLLDAASAKG
170  LFDLVHDFAFHVPIIVASEIIGIPTDARELFRAAFEKSAGLMQPKRDEESWAESLDAA  343
344  RWIGRYIKGLIAERRASPQDDLITGLIRAEEEGDRLSEAEMSSAISTIYTAAGTTTERFI  523
524  SSGIFILLSHPEQWRALVADPKLLDGAIEEILRFHHPMQSTSNNRRCTVDTPLG  685
682  GRQLIRAGDTIRVGLGAANRDPAV*SDPDTFNI  780

CYP1010A1   Parvibaculum lavamentivorans DS-1 
            CP000774 (genome) ABS61705.1 (protein)
            CDS  complement(82741..84153) locus_tag="Plav_0082"
            37% to CYP205A1 Chloroflexus aurantiacus (eukaryote-like P450)
MAMRAERFDEEAPEIFIPARPVPPKEAPGIGAAVFRPQLLANLIASYPEFWYSARSCPFRVGIARGGRGM
LVNDPDAIRRILVSDAEHFPKDDNQLAILKPLLGNGLLTAEGATWRRNRKLAAPIFQHSSVRDFAPLFVR
AAERSARRALEQQGFFPLDREMTKLTLEIIGETVLSANLEDDIDGISHTVTSVLDKFPAMFLASAFLPGQ
LRNRVIDTVVRPGRRALDVFARRIIDEARKSGEETTLLQRLMVSQSKAGHEMTLDQVRDEVATFLLAGHE
TTATTMSWVWYLLTVHPEWQERLYEEVWAVTEGRRLTIDDVPALVETRAVIEEALRLYPPVANLMRRAIK
TTELTPDITIERGQTVLISPWLLHRHRFFWREPDRFDPTRFLGEEAATRPRHLYIPFGGGPRICIGASFA
LLEAVLILATFMQRARVKVINADQVMPQARIVLRPNVALQAVVTPRRPGG

CYP1011A1   Crocosphaera watsonii WH 8501
            ZP_00517718 
            similar to CYP107 family 
            46% to CYP149A1 Microcystis aeruginosa C-term
            note="In CYP149A1 the amino acid residues 2 to 200 are similar to
                  polyketide synthase
                  The amino acid residues 217 to 502 are similar to
                  cytochrome P450.
            45% to CYP1011B1 Gloeobacter violaceus PCC 7421
MTKTKKNKTQNKLVFNPFYRAFHNNPYPIYERLRNEDPIHWSFLKAWIITRYQDVDTILKDNLFQVDDLP
LRLEEKSAYLKQGNFLPLAKTIDKWLFFQQPPNHTRLRSLVNKSFSPASVGNMKEEIEAKVNHLLDKVIP
TGKMDLIDDLASPLPAMTVTNILGLPPEDYYKLIHWSYELFFVFDQPMSLEGYEKQNKMAMEAREYLLRF
IANIDENSQGLIADLVKAKDEENKLDEDEILGFCIMLLIVGQETTKSFISNSILALLQHPEKLQELKDNP
EIIKEASEELLRYDTPVQVIARLAREDVEIGGKTILKGDKVILCLGGANRDENKFPNPEKIEFQRSNRNL
PFGGGIHFCLGAFLARLQGQISINRIVQRLPNLQLVNQTPDWRESITLRGLKSLPLTFDKNDIKTD 

CYP1011B1   Gloeobacter violaceus PCC 7421
            NP_924888 
            similar to CYP107 family
            45% to CYP1011A1 
MDSVANLNQDAFGNTLPQTEAPFKFNVFDPAFHEDPYPFYDRLRRESPIYRNFMGAWVFTRYSDIKSILR
DRRFRVLDKPGWIKNKNRYLTPDQGNFDALVRSSSKFFFFLEPPDHGRLRGLITKAFSASFVDRLRPHVE
ATLADLLGKVREQGAMDIMADLACPLPAIVIARLIGVPAADYARLGHLSDELARIFDPVISLEGYLHLNA
VVEEFGSYFLDLVAEHKRQPGTDLIDSLIAAQEEGNRLSEEEVVAVCMQLFAGGEETTVNLIGNGMLALL
THPEQLELLRSKPEIIAGAVEELLRYDSSIQLVARAAIEDIEIEGCTIGAGEHVHLYLGAANRDPAQFFD
PHSLDLTRVDNRHLAFGDGIHHCFGGPLARVEGQVVFQTLVQQFPKLRLAESRRPERREGTLLRGLKTLP
VTF

CYP1012A1  Streptomyces peucetis
           No accession number
           Pramod Shrestha
           Submitted to nomenclature committee May 16, 2008
           Clone name SP_7691

CYP1013A1  Streptomyces peucetis
           No accession number
           Pramod Shrestha
           Submitted to nomenclature committee May 16, 2008
           Clone name SP_1171

CYP1014A1  Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)
           ZP_04000645, ABTX01000007.1 36825-35530
           38% to CYP174A2, 37% to CYP1003A1
  1 MGDNGPPTPG GLPVLGNTVA FARDPFSFID SAVTTHGDVI RLSMLGRDRY IVAHPDLFER
 61 ALVTDRDAFV KTEDFRLAFG DSVLAVDGDE WREQRDLLDP FFFFRQITDY IPKMRKQADR
121 RAESWTPGQT YSAVEEMKGL TFDILGSTLL GQDPGKRSGD DSLRRAADDL NAYFAPTSWA
181 LPGSLPTPSR RRFNRAVTTL REEVDRLLAA DHSGDDLLSV LAEARGEEGY PRSETAVSDQ
241 LVGIIFAGHE TTALALTYTW YLLSEHPSVR ERVEHEIDEV VGDDPVGAEH LSDLTVLERV
301 IKESLRVYPP IHTLPRTTTR EIELGGYSIP EGSEVLLSVR NVHRDERFFE HPDQFDPDRW
361 ERNDAPEYAY VPFGAGPRRC IGQSFAMIEA KTALTELMKR YRLEWAGNGE LDLSPQMTTQ
421 PRGDVPMIVR ER

CYP1015A1   Natrialba magadii ATCC 43099 (Archaea; Euryarchaeota)
            ZP_03692266
            39% to CYP1003A1
  1 MTDPQSTADD RSPRTDAEAG TEPARNDGET GSMRATARTP PPGPRGLPLI DSTLTFVREP
 61 LEFLSDLSTY GDVAGYEAFG REFVAVSDPG LVEEVLVSRD DEFWRGEFEN EFSDAVAIEG
121 VFFAEGDRWR RQRVLLQNAF TPARIQSYAD DMVDETTRLV ERWSDGDVVD LREASSTLTL
181 RALTRSLFDL EFGDDRAERV RRWVHAMGVY NDTEFFGVRA VLPTWLPSGA EREYRRATAD
241 VEALVEGLVA DRRQSGTDGD DLLSLLATGA YPDGSRPSAE EITDQLLLFL LAGHETTATA
301 LTYACWLLAG DDADVDVDAD IDADADAGAD FDVDVDGGAD ADADFDTASV RSQLEREVDA
361 VCGDRNPTFT DLPELSVTEA VSREALRLYP PLPFLQREPH ESTAVGGYRI DPGTTVQLNM
421 YGIHRDDRWW SEPDAFRPAR WLSADEDGRP VLDARTDTNR PEYAYFPFGG GPRHCIGMRF
481 AMTELQLSLA TLVQHADFDR ITESIDPSFK VSLDPGPVEM RVRKR

CYP1016A1   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0162
            36% to CYP150A9 Mycobacterium vanbaalenii PYR-1
            35% to CYP150A5 Mycobacterium marinum MM4737
            34% to CYP194A1 Bradyrhizobium japonicum

CYP1016A1   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000115.1 3646-4842 (-) strand, EFG78513.1
            4 aa diffs to CYP1016A1 Mycobacterium indicus pranii

CYP1017A1   Sphingomonas wittichii RW1 
            GenPept ABQ67388
MSGSRDIDHH AVAFARDHLA IYRDARAHCP VLRSDAHGGF AILTRYADNR AALRNHDTFA
SGRIRAGDRL GGGVAIPPNG LRIGMIEMDG AEARALRALL QPWFTIAAVE AAAPRMAQLS
AWLVDRIIAR GACDVVEDLA KPMPSLLILD ILGLPLDRWR DYGRVLHEAV AKSSGSIDGL
RWLASDLRAS VERREVHPEG LIAAMIAAEV DGRPLGDALV CELAMMLLFG GTDTTIAAIG
HALRHLTEHP ADRAALVARP ALIPAAVEEI LRLYSPSTGV ARTVTAPVEI GGERFEPGQR
VLCAINSANR DEEMFADAER FDLDRPKRPH LAFGWGVHAC LGQNLARADL RILLGELLAR
MPDFAVDVAA SERYASIPLV NGHARMPMRF TPGTPAGTGG GELPILTAPR LRPLP

CYP1017B1   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0161
            45% to Sphingomonas wittichii RW1 CYP1017A1
            37% to CYP188A3 Mycobacterium marinum MM4717
            33% to CYP222A1 Thermobifida fusca GenEMBL NZ_AAAQ01000022.1

CYP1017B1   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000115.1 4886-5812 (-) strand
            95% to CYP1017B1 Mycobacterium indicus pranii

CYP1017C1   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000109.1 13577-14839 (+) strand
            46% to CYP1017A1 Mycobacterium indicus pranii

CYP1018A1   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0241
            52% to CYP1018A2, 40% to CYP1018B1
            32% to CYP239A2 Pseudomonas sp. KIE171 GenEMBL AJ311159 4194..5354

CYP1018A1   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000109.1 29026-30219 (-) strand
            100% to CYP1018A1 Mycobacterium indicus pranii except
            the end that seems frameshifted in the pranii seq.

CYP1018A2   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0283
            52% to CYP1018A1, 41% to CYP1018B1
            32% to CYP194A1 Bradyrhizobium japonicum USDA 110 GenPept BAC48170

CYP1018A2   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000108.1 3707-4894 (-) strand
            98% to CYP1018A2 Mycobacterium indicus pranii 

CYP1018B1   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0281
            43% to CYP1018A2, 40% to CYP1018A1
            31% to CYP194A2 Rhodopseudomonas palustris NZ_AAAF01000001 gene 
            = Rpal3007

CYP1018B1   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000108.1 6175-7389 (-) strand
            97% to CYP1018B1 Mycobacterium indicus pranii 

CYP1019A1   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0272
            53% to CYP1019A2
            34% to CYP194A2 Rhodopseudomonas palustris NZ_AAAF01000001 gene 
            = Rpal3007

CYP1019A1   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000109.1 3763-4911 (-) strand
            97% to CYP1019A1 Mycobacterium indicus pranii 

CYP1019A2   Mycobacterium indicus pranii
            No accession number
            Submitted by Vikram Saini Oct. 7, 2009
            Clone name MIP0295
            55% to CYP1019A1, 34% to CYP1018B1
            33% to CYP194A2 Rhodopseudomonas palustris NZ_AAAF01000001 gene 
            = Rpal3007

CYP1019A2   Mycobaterium parascrofulaceum ATCC BAA-614
            NZ_ADNV01000107.1 7908-9115 (-) strand
            98% to CYP1019A2 Mycobacterium indicus pranii 

CYP1020A1   Frankia sp. CcI3
            YP_481145.1
            ABD11416.1
            not like alni P450s same as ABD11416
            31% to CYP211B1 Salinispora tropica
MRNTAPRASKGPNQLLTTLLATLPRPDPFPLYAELHQQGESFRSPLGTVYLVSHARCSESLRDPRLAVED
AALRARHRPGWADEAWSPFFDSLLFLNGADHRAVKTVAQSLLVPRALRLLEEGLETATDEVLGALAGAAK
AGEAIDVCHDVAWPLQLYTLSTFLGVGPGELDFLPGLMPRLVVLGSPLMWHSADDAKHAAEASRTLVAFF
KRIIEQRSELAARLGARWEHGLVHRLLASADAGGLDTSDVLATLVAVVVAGVETTIGLIANAVVEILRDP
RGTDFGDLRGPDSTPFVEEVIRLAAPIHIVGRRALESGTVVAGHEVPAGAHVVLLLGAALRDPAMFPEPN
QIDPTRAAGSSLAFGSGPHYCLGAALARIQLRAVVGGLFTRYPQLRLSGEPQLGRHLNPHSYSSVPVLLA

CYP1021A1   Frankia sp. EAN1pec
            YP_001506746.1
            ABW11840.1
            44% to CYP107D1 Streptomyces antibioticus
MSVTETVPQDQDQDLPSFPFPDTFSPLPSGTLAEIARRAPAIRVRFGPGQIPIWLIVRHSPARAMLSDPR
FSRTKTLEFRPPLTGAQIPDPNSLLWLDPPDHTRIRRLVSTGFAHRRIEQLRPWVAETARRHVTAMTAKD
APADLRAALAAALPVDVICQILGVPEIDRENVRTWSETLFRFATNREAAAAGQKALYGYMDSLVRERQAQ
LAAGEPVTKLFDVLITTQDTDDGRLNEVELRSLALTLLIGGFETTAGVITNAVTTLLTDRSQWESLVGNP
ALLPNAVEELLRYHPLSMTFPRVATEDVDLGEFTVRAGEVAIAPFAATNRDPDLYDDPDRLDLTREPVAN
LAFGHGAHHCIGAHLARVELTEVLSALIDIVPTLRLAVPVSELRYELAAPIGRPEKLPVAW

CYP1021A2   Frankia alni ACN14a
            YP_714124.1
            CAJ62566.1
            70% to YP_001506746 EAN1pec
            41% to CYP107D1 Streptomyces antibioticus
MSITEAVQNDQEIPSFPFDDTFSPHSSERLAEYAREAPAIRVRFGPGQLPIWLIVRYAPARAMLADSRFS
RTRTLDFSPPLTAGQMPDPNSMLWLDPPEHTRIRRMVNAGFAHRRIERMRPWIAATARARIDAMTAQGAP
GDIRTLAFHLPIEVICQLLGVPDLDREKVRTWSESLFRFHLDPKGAAEGLFALYGYMGELVRARKAAAGD
THSPEGLLDVLIAAADDDGTLTEPELHSLAMTLLIGGFETTGGVISNVITTLLTQRSHWESLVADPSGMP
NAIEELLRYHPLSMTFPRVATEDVDLGGFVVRAGEVVVVPLAAMSRDPAVFTDPDRLDLTREPVPNLTFG
AGVHHCIGAHLARVELTEVLTALIETVPGLRLAVAPAELRYELKAPIGRPETLPVVW

CYP1022A1   Frankia sp. EAN1pec
            YP_001506696.1
            ABW11790.1
            33% to CYP107X2 Saccharopolyspora erythraea
MSTQAFEDFDPFDLAQAERHHAVMADMRERCPVARLSSGMIAVTRFADVRATLHEPALRNSHAARAPGVT
VPPEDRFFFFEYDPPEHHELRRLLLDLLSRRQSEQLAPSIRALVTELLTPLVGRGGAELVNEFSIPLASR
LMMRVAGFPEDDAPQWRQWIRDMVRSGFSFTNRNERGAGFEQCYPDVLAYLDGRLASAPATDSAQHGVLA
RVRDAQIDGEPLTRTQQRMILFSVVSAGTNTLANFMSNTLASLTREPGLFESLRDDRSLVPVVVEESLRR
DSPSMHLTRLCAEATTIADVPVAPGEKVLLSLASANRDATVFPDPDEFRTDRRDQPSHVAFGWGAHLCLG
APVARQAGVTMVDTFLGLVGAITLEPGTSPVPYLSPQGNGLDELRVCLAPTRAPARAET

CYP1023A1   Frankia sp. CcI3
            YP_480874.1
            ABD11145.1
            40% to CAJ62848
            31% to CYP220A1 Burkholderia fungorum
MATLPDLGDADALRDWHTSFRAIREHQRMYWDDAVGAWLVTRHADVEMGLYDHRLSSQGPTSFMAQLSAE
DLAKFADLQRFYESWMVFSNEPYHTVVRGSVQRVLTPRAVQKRQEAVRAAARSLLDRARAEVVDVNSDFA
RPLATAVISEVLGVPEQEWDNCSRWSHHIIDFISAPQPDASRAMAAAESYDQMCDYVYHLVEEHRRTGRD
DSPMLAVADVGAHAVVGTFAQFMTGGCDPISAAIANAVATLLAHPDQMQRLERDRSLIPTAIEEFIRYES
PFTLVPRVVTEPMTVAGQHLHEGSRVLFMLLAANRDPGVFERPDEVDVGRSPNPHLGFGKGSHYCIGAGL
ARLEMTESIEAIIDMAPNLELAGQVEWSSSLGLRSAVKLPVSVSR

CYP1024A1   Frankia alni ACN14a
            YP_713272.1
            CAJ61705.1
            40% to CYP125F1 Mycobacterium avium subsp. paratuberculosis
MTIVETESIDLYSLASFEHGHPHALYARLREHDPVHWNDEPNGPGFWAVTRWEDIRAVNRDDENFSHWPV
SMIEDFMETEDKSMVNLDPPLHTVIRRAVVPGFMPSAVRRRMTRFVDAAEAIVDEIRPAGGCDLAVDVAG
KIAAYVTADVLRIPREDAVRLYEYIEIGLGGGAYTEQERQGATEALIRYSIQVWEDRRAHPGDDVCSMLA
ACEVDGAPMSLENFSANMTLLIVGAGDTTRHLIGGGLHALFTHPDQRELLQADLDGRMPAAVEEMLRWVT
PVVYNRRTALRDVEIGGRSISAGDKVCVYYGAGNRDPREFADPERFDITRSPNRHLAFSGLGQHFCLGAH
VARAEAIAMITTLLRAFPGIHPAGEMEWTRSNFVMGPAHLPVTW

CYP1025A1   Frankia sp. EAN1pec
            YP_001511098.1
            ABW16192.1
            37% to CYP254A2 Rhodococcus sp. RHA1
MNQMPTPAAAAAPMPDEWCLKDFDHLSTDLAAVFPETMDRMRTLCPVTHTGQHGGFWVVTKYGDVLDVAQ
DWESFSSAYGLAIPPSTTHVRNIPVEVDPPEQRVYKKLVNSHFTPKAIAGWEAPARALVTDLIDEFIERG
ECEFMDDFARPFPSLSFFKFALDAPTEDLDKVSFLASKASIPNDPIGKECWAGLSEWINGFVEQRRQRPP
RGDVVDALLKAEFEGRPLTQKEIVGIVQLLILGGLETTAGALGLMLLRFSRQPEIPAYLRAHPERIPAGV
EELLRLDGPFIAIARTATRDIELDGKQISKGDRVLIYWASANHDDAEFTNPKTFDIDRSPNRHLAFGAGP
HRCLGSNVARLNMRIALEELLRRMDDIRLREDADIHFHSTLTRAPLHVPITFTPGPRSAPVG

CYP1025A2   Frankia sp. EAN1pec
            YP_001509704.1
            ABW14798.1
            36% to CYP292A1 Mycobacterium vanbaalenii
MSYDSTAASGERAGPAGESIDDDWCRNQFDHLSQELVDNLYPALTRMRSLCPVTHSNQYGGYWVVTKYDD
VLRVAQEWETFSSAFGLTVPPSPIATRNLPVEIDPPLQREFKRLINAYFTPKAVRPWEPRTRALVNRLID
GFVERGECDFMAEFARPYPALSFFDVAIGAPADQIERVAYLASKSGAPKDPDAAACWRGLSEWINGFLEQ
RRCEPPRGDVVDAILSAEIQGRPITHEEIIGTVQLLILGGLETTAGALGQIMLRFCRQPEIPAALRENPD
LLPQAVEELLRLDGPFVQITRTAMHDTEIDGHQIKQGEKVIIYWASANRDEGEFPASDEFDLDRKINRHV
AFGVGPHRCVGSNLARMNLRIALDELLRRLHDLRLRDGAEIHFHPTVNRAPVAVPVTFTPGPRVGADG

CYP1025A3   Frankia sp. EAN1pec
            YP_001508195.1
            ABW13289.1
            37% to CYP254A3 Rhodococcus sp. RHA1
MTDAATGQLDAEWVEHHFDHLSPELARDLHPTLALARSRCPVAHSDQYDGFWVVTGYEDVLRVAQDWETF
SSELGITVPHTPTPMKILPVTIDPPLQRTFKRLINTHFRPVVVVEWEQQTRALVNRLIDGFIEAGECDFM
TEFARPLPGLAFFDMALHAPAEDLEMVNHWATLASLSHLEESRESHGKLAAWIGALMAKRREEGPRGDVV
DAVMNADIEGRPITPAEAVGTVQLLVLGGLETTAGALGMSMIRFCRHPEILARLRENPELIPDAVEELLR
LDGSFICIARTARHDTELGGRQIKAGERVLIYWASANRDESEFDNADTFDLDRGRNRHIAFGAGPHRCAG
SNLARMNLRIALEEIVTRLVDVRLQPGADIDYHSTFNRAPQSVPITFTPGPRLTPAG

CYP1025B1P  Frankia alni ACN14a
            CAJ58987
            CT573213.2, no YP#
            42% to CYP188A5 Mycobacterium vanbaalenii
VLSDLTEAEIDGERLSDEELSGIVMPLLLGGMDTTAGRTGNAFLRIDADP
ALRRRLLEDPAVLEIATEEFLRRDTPVQGLTRVVTRDAQFHGRQLKKGDR
VMLMFAAANRDPSTFACPHDIDLDCGTNRHLAFAPVVHRCLGSNFARAMF
RVMITALLRRLPDGHVAPPVERLADAGDVYTVKHLPVRLTPGPREGVGPP
ACASRTA*

CYP1026A1   Frankia sp. EAN1pec
            YP_001508774.1
            ABW13868.1
            38% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
MSVDDTEASAPTTQRGYATAPTLAGFSHAANERLNADPWGELDRLRDESPTFRSDMPNPLVPGASLWYLL
DYESVYTALRDWETFSNVGSAHPFSDSDPYSMIPGELDPPDHTKFRRPLNAHFSPGAIRALEPDIRRTAV
ELIESFKDSGQCDFVTDFALHFPTRVFERMFGVPLEDHDQLTAWVHTFGQQMATQTAIDKAVAAEQEVLA
YLGKKLDEREQSPREDLLGAIAFMEVDGARISRKEQVAVAYLMFQAGMDTVASQLGWSFRHLAENEVDRQ
AILADPKLIPSTVEELLRSYDILSHTMIVAKDVEFNGCPMKKGDRVVTMISAANRDPNEFPDPDTFDVSR
KPNRHMAFGVGPHRCIGAHLARIELNIALEEWHQRIPNYKVAEGAEFGQSMKWAVTSMESLPLEWDVEAV
N

CYP1027A1  Frankia alni ACN14a
           YP_713106.1
           CAJ61538.1
           37% to CYP272A1 Mycobacterium avium subsp. paratuberculosis
MTTPTTEITDHRIVGVGTVGDAGDRFDALRSLHRIVRVTEPDRSYWMVLDHDLARECLQNPAVFSSEVIT
PLSPDPPLSMIPIQLDPPEHTQWRRLLAQYFSPRTMGLLRPRLEERTTELVAAIRARGECDYVEDFALEL
PTVVFLELMGLPIDELPTFLEWEKQALAPTDSGDFDKDRQIGGIFSVVGYFQAEIARRRDSGERGDGLLG
AMLDWELDGAPAPDDALVNCSLLLFLAGLDTVAMSLSFAMHHLATHDADRRHVAGLAAAGEPLDGVVEEL
LRFYAVPEVGRKVKQDIEIGGQQLRAGDLVLFPLVAANRDEALVAGAGTVDLVSRPPAPHLAFGAGPHRC
LGSHLARIEMNVALAGWHRVIPAYALGEGTAPQAYWGNVHGIFSLPLAEFGS

CYP1027B1  Frankia alni ACN14a
           YP_714309.1
           CAJ62755.1
           48% to CYP1037C1 YP_001508864 EAN1pec
           36% to CYP215A1 Thermobifida fusca
MDYVTGPPPAPALSLFQRMDDHQAAGRPAVRTGEAGGYWIFTDHDVILEGLQQPDLWSSSVIVPTESDPP
YRWIPIMLDPPEHTKWRHLLGSYFSPGRTKAMKAGQHRLAVELIEGLRDQGECDFVRDFAQVFPSTIFLE
IMGMPREQLGEFLRWEHMILHQNNDSDPDGSVRLAGMQAVQTYFAGLVAQRRANPDPHAQDVVSAAISWE
IDGEPVSDADVLNCLLLLFMAGLDTVAGQSSYALLHLATHPADRARIVAEPALIPHAVEELLRAYPIVQT
ARKATRDAQFHGCPIRKGDMAAFPLSAAGRDEQAYPDARRVDLDRPTTRHLSFGGGPHRCLGSHLARQEL
AVLLQEWHRLIPDYELAELPLEHGGGVWGLESLPLRWAV

CYP1027C1   Frankia sp. EAN1pec
            YP_001508864.1
            ABW13958.1
            40% to CYP254A2 Rhodococcus sp. RHA1
MSVTEPVPSRCPAVTYSPHEQRPVGEWTAFFDQLRDEAPVVRNTFANGYYVLTRYEDILSAYQDTDTFST
QAVTVLEPDPSYRWIPHMLGGNEHRQWRRQLGPYFSPRAIEGLDDRIRARAVGLIESFADRGSCDVITDF
SFHFPTTIFLELMGLPVGDLDRFMAWEANILHSNGSTPEEIAHNRTTAMAAVYEYFGSVIADRRRRPGDD
LVSHAIAFKVDGRPVTDDEVLSYCFFMFMAGLDTVAAALGYSLYHLATHPEDRARIVADPALIPSAIEEI
LRAYAFTIPARKVTRDIEVAGCPIAAGSMVQLPIKAAMRDGAAFASASEVLIDRKPNNHIAFGAGPHRCL
GSHLARHELAIALEEWHKRIPDYRLADDAVITELGRSSGPDTVPVVWAR

CYP1028A1   Frankia sp. EAN1pec
            YP_001508760.1
            ABW13854.1
            35% to CYP107AT1 Saccharopolyspora erythraea
MSTVGDRELNGAVGIVHTSIEAVNDGANPYQTLAPLHDYGEAVIMPEGYLAVWGHQACMDIMRSSAWGRH
LPDSSIRAAWQHDLTAEQAELLRQEEPPHIAPWLQTFDGPEHARQRSLVSKPFTPRRLQVMRQRTTEVVG
RLAAAAPRGVPFDFMSTIAFPIPNQVVGELVGLPLQDRDWFAERAVLLLAERDPRSSFDQLRRSTRAIRE
LGDYIRGLLRGETCPTEGLASDLLEAEETGARLTEPELLSLMLLMYVAGHGTTAHSMGNGLYVLLQHPDQ
LAALRADRGLTRSAVEEILRWDSGVTSVDYSAVEDTDIDGIRVPAGTPAHLFLSAANRDPRVYTDPGSFD
IRRTEGPTVVFGAGPHFCLGAALARLELEIALDVLLAGFASIELATSTPPRGDSFNYRYFTQLPIVVSDN

CYP1029A1   Frankia sp. CcI3
            YP_480965.1
            ABD11236.1
            40% to CAJ62848
            42% to CYP107AH1 Streptomyces peucetius
MDGQGSVRRYINVYRNDNDIRGLENLETRVEESDVVWIIPAVAGGSIRPAVQEPKVPEVLPSEFFLNPGP
SPHATNAELRSKCPVHQINYPPGSEAYAVLGHRAVAEAFTDSRLSKEAENLPPRFRDRALSSSLLMVRNL
GFADPPDHARLRRPISRAFLPNAIADLRPRIQDVVDDLIDTFPAPGEIDLLGAFALPLPLTVICEYLGIP
VQDRPLFLEWGYILSQDPFQHAESELKAATEEFTDYFTRLVARRRTDLRKDLLSELVRAADSDALSEREL
LSTILLLLIAGHKTVANLIGNGTALLLGHPGQLDLLRTTPELIPAAVEEMLRFEGSAAWASMRVAVEDMR
LAGTEIPRGSFVHLLLSSAGHDPEAYDEPERFDVTRSPNHHLAFGHGAHFCVGAPLGRLQGDIAFTTLLR
RLPGFELAVRQDEVEWLADSSLSRGLRALPIRVRERLPR

CYP1030A1   Frankia sp. EAN1pec
            YP_001510577.1
            ABW15671.1
            38% to CYP147F1 Streptomyces peucetius
MPVQTMDFAAPSFRTDPFPAWSDLRRAGPLHRDVSGAWIVVSHREVGRLLADPRVGKDLRRLSTYGAQRP
YGPDGLAEYYIEQWMECRLPTMHRRWRQLVLPGFTHRAVHGLRAELCRTADDLLTHALTHAPSDGQVDLL
RDFARPFPVAVIVRVLGLTDLDTDRLAQLSRTIAAVLEPNAAVSAREAGDAALAELAGLLWDAVRADRGP
HPDGFLRRLVDANKGLLSPEQLIATVLLLFLSGNDTITGLIANGVLALASVPDQADRLRAHPELLPMAVE
EVLRFDAPACVAVRTTYEPMTIDGVTVERGAALLLAISSANRDPAAFAEPDVFRVDRRPIRHFAFGSGDH
TCVGIGLARMEATIALEALLHRFPRLTHDPSTLRWSDALYLRSPENLVLLCTVPPAPERACGVPEVGLGR
DLG

CYP1031A1   Frankia sp. EAN1pec
            YP_001506244.1
            ABW11338.1
            41% to CYP107AN1 Bradyrhizobium japonicum
MTDTRTPRAASGPYVFNPFADGFAEDPYPHYAQLRENAPAHRHPLGFWLVSRYEDVARIQRSGHSVDERH
ITELPEWKSESRTLGKQNRLMHGLSMLDQDPPNHTRLRRLVTKAFTRRAVDALEGRIERIVDDALDRMAE
AGRVDLVAELAFPLPFTVISELLGIPVLEHGRLRELTGTMVRALEPLPDPGLQAEIRAANDEVAAIMRAV
TDWKRDNPGDDLLTALIGAEHDGDVLSAEELVAQVMLLYVAGHETTVNLVAGGILTLLRHPDQMRRLRDE
PELAGNAVEELLRYDSPVHLMRRITLEPLSVRGTEIPPGVFVTVCLAAANRDPDFWGPDADEVRLDRTDA
HRHVSFGAGIHHCVGAALARLEARVAISRFVGRFPAPALEDVRWNGRINVRGPASLTVAVR

CYP1031A2  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7216
           57% to CYP1031A1 Frankia sp. EAN1pec

CYP1032A1   Frankia sp. EAN1pec
            YP_001508733.1
            ABW13827.1
            43% to CYP107AZ1 Roseiflexus sp. RS-1
MRFDPTAAAIKADPYPAYARLRAEAPVEWNDLGFWTVARHQDCLFALRDKRLGKEHPFAWAIENPDLPLI
QIHDAMMIFHDGQAHRRVRRLFTSAFTTRAADRLRPDIAAIVDELLAELVERDEFDLVSQFCYPVTLRTI
CYMLGVPRSDIDWCHSLTKNVQRLLEQDLSRAELVQISDSTVTLSEYFAEHVRDRRRNPKDDLISLLVQA
EIDGERLTEEEIIANSILLYLGGEDTNANLMANSTLALLAAPDQAELLRHDAGVVHATAFDELLRYDSSF
QMLTRYANEPVEIGGQRIEEGQTVMCLLGSANRDEREYERPDELDLRRVVKRGVSFGGGPHLCVGAPLAR
AQLQEALPRLFRAFPWMQNLTEELEYPLLVVRGPKELTLATGKQRVMA

CYP1033A1   Frankia sp. EAN1pec
            YP_001508979.1
            ABW14073.1
            35% to CYP187A5 Mycobacterium ulcerans
MLKPVQPADRIVGDVDDDVDYVDGQITDFHARLAALRAEKGVARLRFGPDTGLMLLRHADVVVALRDETR
FSKSGAFRPITFPFLGPNITGYDGHEHNVKRALVSPTFRRTMIPRYIQPVIRPIAEELVADLATLGEADL
MATFAKKYPMRITSRLLGIPSDEEDKLASWAFSMLHIAGDPDGAMKANAEFTEYVGPLIDTRRAHPRDDL
LSALLTEEVEGQHLDHDEVLGFLRLLFPAGVDTTWQALGSLVHAVLEHPEVHQRLRRDEEERAWAVEETL
RWESPVAADSRLTLQDVVVSGVEIAAGELVRLGLSVANRDPDVFPDPDRWNLDRRPTNHITFGLGRHFCL
GAHLARVELQVALDVLLQRLPNLRLLEQPQITGIGIRGPKTLRVAWDAPSTPGAP

CYP1034A1   Frankia sp. EAN1pec
            YP_001504987.1
            ABW10081.1
            37% to CYP187A1 Mycobacterium smegmatis
MSTTATLDRERVRQLFDLRSSYNVHMGGGYRQDPYPVWHRLREQAPVHPGIVHELTGFDGPAMFSGLPYP
DRPHFSAFSYAACDAAYRDPEVFASAAGPVDPNNGPYGATNSMLSMGGRQHRRYRGLVQPSFVPGKAKWW
ISNWIEETVDLLIDGFVDAGRAELNVDFCAAIPVLTITSSFGVPVDRALDIRAALTRPDEIVRMLEPIVA
ARRADPQDDLISILVQAEMTDENGVTHRLTDAEIYSFSVLLLTAGSGTTWKQMGITLTALLQHPEALAAV
RADRSLLRLAIEESLRWSPTDPMFSRWVTEDVDFFGVHMPAGSVLHLCIGAANRDPARWDRPDEYDITRA
LRPSFAFGGGAHVCLGMHVARAEMRVGIGALLDRLPDLRLDPDREAPRFIGMYERGATEIPVVFG

CYP1034A2   Frankia sp. EAN1pec
            YP_001509649.1
            ABW14743.1
            35% to CYP187A2 Mycobacterium avium subsp. Paratuberculosis
MTRPDSIVLLDRARLREVFDLRNEANLGTVAGYEEDPYPRWHELRELAAVHPGTLHELTGFSGPVLFQGL
PFEDRPHFTAFTFAACDEALKNQEVFASSPVAVDLEGGRLAPLNSIFSMAGAQHRRYRRLVQSSFVPPRM
AWWTEKWIETTVHALIDWFAGDGSADLNVDFSAAVPVLTITGSFGVAVEQAIAIREALSSPERLVPLLAP
IIAARRETREDDLISVLVDAEVQDDDGNPHRLSDAEIYSFAVLLLMAGSGTTWRQMGIVLTALLQRPEIL
DAVRRDRQLLRNAIDESLRWMPTNPMFSRFLTKDVEFHGAHLPKGAVLHLALGAGSRDPRRWERPDEFDV
TRPPKPSLGFGGGPHVCLGMHVARAEMYTGIGALLDRLPNLRLDPDANPPRIIGMYHRGPTAIPVLFG

CYP1035A1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_8399
           34% to CYP107BH1 Frankia alni ACN14a  

CYP1035A2   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY3625 74% to CYP1035A1

CYP1036A1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_10544
           43% to CYP145C1 Streptomyces scabies SCAB90701 
           42% to CYP217A1 Thermobifida fusca

CYP1037A1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_3522
           38% to CYP163B1 Salinispora tropica (marine actinomycete) 

CYP1038A1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7163
           33% to CYP208A1 Streptomyces globisporus 

CYP1038A2   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2020 81% to CYP1038A1

CYP1039A1  Streptomyces bingchenggensis
           No accession number
           Wensheng Xiang (Ann)
           Submitted to nomenclature committee Jan. 30, 2010
           Clone name SBI_7500
           42% to CYP107AV1 Saccharopolyspora erythraea NRRL23338 

CYP1040A1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE1257 32% to CYP107T1

CYP1041A1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE4151 31% to CYP183B1

CYP1042A1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE4609 32% to CYP135B4

CYP1042A2   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY972 75% to CYP1042A1

CYP1043A1   Streptomyces SN-593
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Jan. 28 ,2011
            SRE9042 29% to CYP174B1

CYP1044A1   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY2316 39% to CYP107L2

CYP1045A1   Streptomyces RK95-74
            No accession number
            Shunji Takahashi
            Submitted to nomenclature committee Feb. 3 ,2011
            SCY910 81% to CYP1045A2

CYP1045A2   Streptomyces sp. MP39-85
            GenPept ACO94495.1
            ML-449 biosynthetic cluster

CYP1045A3   Streptomyces sp. DSM 21069
            FJ872523.1
            BE-14106 biosynthetic cluster
            BecO 

CYP1046A1   Streptomyces griseus
            AP009493.1 444916-446232 (+) strand
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR410
            84% to CYP208A1

CYP1046A2  Streptomyces anulatus
           HM038106.1 
           Actinomycin biosynthetic gene cluster
           89% to CYP1046A1

CYP1046A3  Streptomyces flavogriseus
           CP002475.1 49894-51195 (-) strand
           84% to CYP1046A1

CYP1047A1   Streptomyces griseus
            No accession number
            Takuya Makino
            Submitted to nomenclature committee May 23 ,2011
            SGR1079
            37% to CYP197C1

CYP1048A1   Streptomyces scabiei 87.22
            FN554889.1 361391-3615100 (+) strand
            Only 33% to CYP107P4 Streptomyces bingchenggensis

CYP1048A2   Streptomyces turgidiscabies 
            AY707081.1 13770-14990 (-) strand
            Pathogenicity island
            87% to CYP1048A1
            33% to CYP107BT1 Streptomyces SN-593

CYP1049A1   Burkholderia sp. CCGE1002 
            YP_003609334.1

CYP1049A2   Burkholderia phymatum STM815 plasmid pBPHY01
            GenPept ACC75152.1

CYP1049A3   Enterobacteriaceae bacterium strain FGI 57
            GenPept AGB77447.1

CYP1050A1   Rhodococcus erythropolis 
            AB694012
            rauA gene from rau gene cluster for aurachin RE biosynthesis
            36% to CYP164A3 Mycobacterium marinum
            33% to CYP164A1 Mycobacterium leprae
            32% to CYP164A2 Mycobacterium smegmatis

CYP1050B1   Streptomyces sulphureus L180
            AJTQ01000106
            46% to CYP1050A1 Rhodococcus erythropolis
            42% to CYP107BD2 Frankia sp. Ccl3
            40% to CYP107P4 Streptomyces bingchenggensis
            less to other CYP107 sequences

Unidentified fragments

Rhodobacter capsulatus 1st sequence from a genome project
Rhodobacter capsulatus 2nd sequence from a genome project
Rhodobacter capsulatus 3rd sequence from a genome project 32% id with U08223