Comprehensive bacterial P450s Sept. 13, 2007

892 entries – 3 frags, - 11 variants, - 30 renamed seqs – 2 duplicates, - 1 deleted region in M. bovis

 

total of 853 unique sequences

18 are archaebacterial and 835 are bacterial

 

updated August 12, 2009, 923 sequences

Sept. 4, 925 sequences (3 new archaea)

 

Updated July 22, 2011

1200 bacterial sequences (95 confidential sequences removed from public file)

This file includes 27 Archaea.

 

D. Nelson

 

>CYP51B1    Mycobacterium tuberculosis (Actinobacteria) Rv0764c

MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ

LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN

AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ

LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT

DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR

DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV

QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH

RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG

V

 

>CYP51B1    Mycobacterium marinum MM4932

MTTAIVPRVS GGEEEHGHLE EFRTDPIGLM QRVRDECGDV GWFQLANKHV VLLSGAKANE

FFFRSSDEEL DQAEAYPFMT PIFGKGVVFD ASPERRKEML HNSALRGEHM KGHATTIERE

VHRMIENWGQ EGEIDLLEFF AELTIYTSTS CLIGTKFRNQ LDSRFAHFYH ELERGTDPLC

YVDPYLPIES FRRRDEARKG LVALVQDIMH QRVANPPTDK RDRDMLDVLV SITDEQGNPR

FCADEVTGMF ISLMFAGHHT SSGTSAWTLI ELLRHPDAYA AVIDELDELY ADGQPVSFHA

LRQIPRLENV LKETLRLHPP LIILMRVAKG EFQVEGYPIH EGELVAASPA ISNRIAEDFP

DPDEFVPERY QEPRQEDLIN RWTWIPFGAG RHRCVGAAFA TMQIKAIFSV LLREYEFEMA

QPADSYRNDH SKMVVQLARP ARVRYRRRKM SDNRGH*

 

>CYP51B1    Mycobacterium ulcerans

MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLANKHVVLLSGAKANE

FFFRSSDEELDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHATTIERE

VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCHELERGTDPLC

YVDPYLPIESFRRRDEARKGLVALVQDIMHQRVANPPTDKRDRDMLDVLVSITDEQGNPR

FCTDEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAAVIDELDELYADGQLVSFHA

LRQIPRLENVLKETLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFP

DPDEFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA

QPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH

 

>CYP51B1    Mycobacterium bovis subsp. bovis AF2122/97 (Actinobacteria)

MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ

LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN

AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ

LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT

DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR

DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV

QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH

RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG

V

 

>CYP51B1    Mycobacterium avium (Actinobacteria)

TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 3021539

3021540 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 3021719

3021720 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 3021899

3021900 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 3022079

3022080 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 3022259

3022260 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 3022439

3022440 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 3022619

3022620 PADSYRNDHSKMVVQLARPAKVRYRKR 3022700

 

>CYP51B1    Mycobacterium smegmatis (Actinobacteria)

VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS 4858988

4858989 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV 4859168

4859169 ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 4859348

4859349 LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 4859528

4859529 VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 4859708

4859709 NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 4859888

4859889 DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 4860068

4860069 YRNDHSKMVVQLARPAKVRYRRR 4860137

 

>CYP51B1    Methylococcus capsulatus (Proteobacteria)

908332 MSHPPSNTP

908305 PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 908126

908125 DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 907946

907945 LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 907766

907765 NLPLPVFKRRDQARVRLQELVTQIMERRARSQERSTNVFQMLIDASYDDGSKLTPH 907598

907597 EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 907418

907417 PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 907238

907237 FDPDRYTPERAEDKDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE 907061

907060 SYRDDYRKMVVEPASPCLIRYRRRDAP 906980

 

>CYP51B1     Rhodococcus sp. RHA1 (Actinobacteria) Rha05830

MNLATPQRVSGGEHEHGHLEELRTDPIALMRRVREECGNVGVFQLADKKVVLLSGAEANEFFFRSTDEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNQALRGEQMKGHAATIAHEVDRMVAQWGDEGEIDLLEFFAELTIYTSSACLIGKKFREQLDGRFAHLYHELEQGTDPIAYVDAYAPIESFRRRDEARVQLVALVQEIMNGRIENPPQGKEDRDMLDVLVSIKDEDGNERFTADEITGMFISMMFAGHHTTSGTAAWTLIELLRHPDYAKQVVAELDDLYSDGSDISFGALRQIPKLEAVLKETLRLHPPLIILLRVARGEFEVGGYRIAENDLVAATPAISNRIAEDFPNPDTFDPERYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFALMQLKAIFSILLQDWEFEMAQPSETYRNDHSKMVVQLQQPCTVRYRKRST

 

>CYP51B1     Nocardia farcinica IFM 10152 (Actinobacteria)

MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFE

LAGKQVILLSGAEANEFFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHN

SALRAEQMRGHATTIAAEVDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNE

LDDRFARLYHELERGTDALAYVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPA

DKSDRDLLDVLVSVPNEDGGPRFSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHP

ELRDRVVAELDELFADGKDVSFHALRQIPLLEATLKETLRMHPPLIILMRVAQGDFEV

CGHHIAAGDHVAATPAISNRLPEDFPDPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRH

RCVGAAFALMQLKAIFSILLRDWEFEMAQPSESYRNDHSKMVVQLQQPCRVRYRRRVR

TS

 

>CYP51B1   Mycobacterium vanbaalenii

MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSE LNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEF FAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVM HGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFY AKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASP AISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM AQPPESYQNDHSKMVVQLARPAKVRYRRRVRD

 

>CYP101A1    Pseudomonas putida

MTTETIQSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWA

VLQESNVPDLVWTRCNGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPT

SMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPFP

IRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQKPGT

DAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLSFSMEFLAKSPEHRQELI

ERPERIPAACEELLRRFSLVADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENA

CPMHVDFSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQH

KSGIVSGVQALPLVWDPATTKAV

 

>CYP101B1    Novosphingobium aromaticivorans

MLPHDRGQNSTRRITAMEAPAHVPADRVVDIDIYMPPGLAEHGF

HKAWSDLSAGNPAVVWTPRNEGHWIALGGEALQEVQSDPERFSSRIIVLPKSVGEMHG

LIPTTIDPPEHRPYRQLLNAHLNPGAIRGLSESIRQTAVDLIEGFAAQGHCNFTAQYA

EQFPIRVFMALVGIEASEAPRIRHWAECMTRPGMDMTFDEAKAVFFDYVGPLVDARRE

TPGEDMISAMINADLGDGRRLTRDEALSVVTQVLIAGLDTVVNVLGFIMRELAGNPAL

RADLRQRGADILPVVHELFRRFGLVSIAREVRRDIEFHGVHLKAGDMIAIPTQVHGLD

PRVNPDPLAIDPSRKRARHSTFGSGPHMCPGQELARKEVAITLEEWLRRIPDFALGPN

SDLSPVPGIVGALRRVELVWNT

 

>CYP101C1   Novosphingobium aromaticivorans

MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTA

NGGHWIAARGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVM

KGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR

PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRP

WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLIPAAADELMR

RYPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIR

HTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPL

VWRA

 

>CYP101D1   Novosphingobium aromaticivorans

MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAW

KRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVP

TKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVF

PVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAA

RRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP

ETVAEMRREPLKLQRGVEELFRRFAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHG

LDDRHHDDPMTVDLSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLK

DRAVPIYHSGIVAAVENIPLEWEPQRVSA

 

>CYP101D2   Novosphingobium aromaticivorans

MGTTRMDTFNPQESRLATNFDEAVRAKVERPANVPEDRVYEIDM

YALNGIEDGYHEAWKKVQHPGIPDLIWTPFTGGHWIATNGDTVKEVYSDPTRFSSEVI

FLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA

RGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAG

NNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVV

NFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFPVVSEARMVAKDQEYKGVFL

KRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGGPHRCAGMHLARMEVIVT

LEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR

 

>CYP101D3   Sphingomonas sp. SKA58

1 MPEHVPETMS RARAPRPEHI PEQYVHEIDM YALEGIEQGY HEAWKNIPKP DMPDLIWTPF

 61 TGGHWIATNG DTVREVYSDP TRFSSEVIFL PKEAGEKYEM VPTRMDPPEH TPYRKALDKG

121 LSLAQIRKVE SKVRKVAVDL IDSFVSRGEC DFSAEYANVF PVRVFMALAD LPESDVPTLS

181 RFAKMMTRPE GNTPEEMAKH LEEGNKGFFA YVEPIIQARR GKEGEDLITV MVNAEINGER

241 ITHDKALGLI SLLLLGGLDT VVNFLSFMMI HLAKNPQVVE ELRADPLKLM RSAEEMFRRF

301 PVVSEARMVA KDQDFRGIEL KRGDMILLPT ALHGLDDQLN DDPWRINLER RGISHSTFGG

361 GPHRCAGLHL ARMEVIVTIE EWLKRIPTFA MKPGAQPIYH SGIVAAVDNV PLIWSER

 

>CYP102A1   Bacillus megaterium

MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFE

APGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHN

ILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFN

YRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVD

KIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSF

ALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL

YAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFK

PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAK

SKKIPLGGIP

 

>CYP102A2    Bacillus subtilis

MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI

HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH

NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF

NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV

DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL

SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF

SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA

YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS

VQSRHQEAIHADVQAAEKAAPDEQKEKTE

 

>CYP102A3    Bacillus subtilis

MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF

DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH

RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF

NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV

DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL

SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF

SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA

YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT

VKPRKTAAINV

 

>CYP102A4    Bacillus anthracis str. Ames

1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFRMQTLSD TIIVVSGHEL

  61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETQEPNWQ KAHNILMPTF SQRAMKDYHA

 121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM

 181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR

 241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR

 301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV

 361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG

 421 MLLQHFEFID YEEYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKNHEIKQ

 481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVAAL NDRIGSLPKE

 541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKG DELKGVQYAV FGCGDHNWAS TYQRIPRYID

 601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQRMWSDAMK VFGLELNKNM EKERSTLSLQ

 661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI

 721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI

 781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF EPFLELLPAL

 841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP

 901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNVGEAHLYF GCRHPEKDYL

 961 YRTELENDER DGLISLHTAF SRLEGQAKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK

1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI

 

>CYP102A5    Bacillus cereus ATCC 14579

1 MEKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKIAEEYG PIFQIQTLSD TIIVVSGHEL

  61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA

 121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM

 181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG DQEENDLLSR

 241 MLNVPDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR

 301 VLTDPTPTYQ QVMKLKYMRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV

 361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG

 421 MLLQHFELID YQNYQLDVKQ TLTLKPGDFK IRILPRKQTI SHPTVLAPTE DKLKNDEIKQ

 481 HVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE

 541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID

 601 EQMAQKGATR FSKRGEADAS GDFEEQLEQW KQNMWSDAMK AFGLELNKNM EKERSTLSLQ

 661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSDRSTRHIE VSLPEGATYK EGDHLGVLPV

 721 NSEKNINRIL KRFGLNGKDQ VILSASGRSI NHIPLDSPVS LLALLSYSVE VQEAATRAQI

 781 REMVTFTACP PHKKELEALL EEGVYHEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL

 841 KPRYYSISSS PLVAHNRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP

 901 QSNFELPKDP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNLGQAHLYF GCRHPEKDYL

 961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK

1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQDEGRYGKD VWAGI

 

>CYP102A6    Bradyrhizobium japonicum USDA 110

1 MSSKNRLDPI PQPPTKPVVG NMLSLDSAAP VQHLTRLAKE LGPIFWLDMM GSPIVVVSGH

  61 DLVDELSDEK RFDKTVRGAL RRVRAVGGDG LFTADTREPN WSKAHNILLQ PFGNRAMQSY

 121 HPSMVDIAEQ LVQKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE

 181 SLVRSLETIM MTRGLPFEQI WMQKRRKTLA EDVAFMNKMV DEIIAERRKS AEGIDDKKDM

 241 LAAMMTGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYTLYALLKH PDILKKAYDE

 301 VDRVFGPDVN AKPTYQQVTQ LTYITQILKE ALRLWPPAPA YGISPLADET IGGGKYKLRK

 361 GTFITILVTA LHRDPSVWGP NPDAFDPENF SREAEAKRPI NAWKPFGNGQ RACIGRGFAM

 421 HEAALALGMI LQRFKLIDHQ RYQMHLKETL TMKPEGFKIK VRPRADRERG AYGGPVAAVS

 481 SAPRAPRQPT ARPGHNTPML VLYGSNLGTA EELATRMADL AEINGFAVHL GALDEYVGKL

 541 PQEGGVLIIC ASYNGAPPDN ATQFVKWLGS DLPKDAFANV RYAVFGCGNS DWAATYQSVP

 601 RFIDEQLSGH GARAVYPRGE GDARSDLDGQ FQKWFPAAAQ VATKEFGIDW NFTRTAEDDP

 661 LYAIEPVAVT AVNTIVAQGG AVAMKVLVND ELQNKSGSNP SERSTRHIEV QLPSNITYRV

 721 GDHLSVVPRN DPTLVDSVAR RFGFLPADQI RLQVAEGRRA QLPVGEAVSV GRLLSEFVEL

 781 QQVATRKQIQ IMAEHTRCPV TKPKLLAFVG EEAEPAERYR TEILAMRKSV YDLLLEYPAC

 841 ELPFHVYLEM LSLLAPRYYS ISSSPSVDPA RCSITVGVVE GPAASGRGVY KGICSNYLAN

 901 RRASDAIYAT VRETKAGFRL PDDSSVPIIM IGPGTGLAPF RGFLQERAAR KAKGASLGPA

 961 MLFFGCRHPD QDFLYADELK ALAASGVTEL FTAFSRADGP KTYVQHVLAA QKDKVWPLIE

1021 QGAIIYVCGD GGQMEPDVKA ALVAIRHEKS GSDTATAARW IEEMGATNRY VLDVWAGG

 

>CYP102A7  Bacillus licheniformis ATCC 14580

1 MNKLDGIPIP KTYGPLGNLP LLDKNRVSQS LWKIADEMGP IFQFKFADAI GVFVSSHELV

  61 KEVSEESRFD KNMGKGLLKV REFSGDGLFT SWTEEPNWRK AHNILLPSFS QKAMKGYHPM

 121 MQDIAVQLIQ KWSRLNQDES IDVPDDMTRL TLDTIGLCGF NYRFNSFYRE GQHPFIESMV

 181 RGLSEAMRQT KRFPLQDKLM IQTKRRFNSD VESMFSLVDR IIADRKQAES ESGNDLLSLM

 241 LHAKDPETGE KLDDENIRYQ IITFLIAGHE TTSGLLSFAI YLLLKHPDKL KKAYEEADRV

 301 LTDPVPSYKQ VQQLKYIRMI LNESIRLWPT APAFSLYAKE ETVIGGKYLI PKGQSVTVLI

 361 PKLHRDQSVW GEDAEAFRPE RFEQMDSIPA HAYKPFGNGQ RACIGMQFAL HEATLVLGMI

 421 LQYFDLEDHA NYQLKIKESL TLKPDGFTIR VRPRKKEAMT AMPGAQPEEN GRQEERPSAP

 481 AAENTHGTPL LVLYGSNLGT AEEIAKELAE EAREQGFHSR TAELDQYAGA IPAEGAVIIV

 541 TASYNGNPPD CAKEFVNWLE HDQTDDLRGV KYAVFGCGNR SWASTYQRIP RLIDSVLEKK

 601 GAQRLHKLGE GDAGDDFEGQ FESWKYDLWP LLRTEFSLAE PEPNQTETDR QALSVEFVNA

 661 PAASPLAKAY QVFTAKISAN RELQCEKSGR STRHIEISLP EGAAYQEGDH LGVLPQNSEV

 721 LIGRVFQRFG LNGNEQILIS GRNQASHLPL ERPVHVKDLF QHCVELQEPA TRAQIRELAA

 781 HTVCPPHQRE LEDLLKDDVY KDQVLNKRLT MLDLLEQYPA CELPFARFLA LLPPLKPRYY

 841 SISSSPQLNP RQTSITVSVV SGPALSGRGH YKGVASNYLA GLEPGDAISC FIREPQSGFR

 901 LPEDPETPVI MVGPGTGIAP YRGFLQARRI QRDAGVKLGE AHLYFGCRRP NEDFLYRDEL

 961 EQAEKDGIVH LHTAFSRLEG RPKTYVQDLL REDAALLIHL LNEGGRLYVC GDGSRMAPAV

1021 EQALCEAYRI VQGASREESQ SWLSALLEEG RYAKDVWDGG VSQHNVKADC IART

 

>CYP102A8   Bacillus thuringiensis serovar konkukian str. 97-27

1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFQIQTLSD TIIVVSGHEL

 61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETDEPNWK KAHNILMPTF SQRAMKDYHA

121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM

181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR

241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR

301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV

361 LIPQLHRDKD AWGDDVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG

421 MLLQHFEFID YEDYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKKHEIKK

481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE

541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID

601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNM EKERSTLSLQ

661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI

721 NNEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI

781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL

841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP

901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MKVGEAHLYF GCRHPEKDYL

961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK

1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI

 

>CYP102A9   Bacillus weihenstephanensis KBAB4

1 MDKKVSAIPQ PKTYGLLGNL PLIDKDKPTL SFIKIAEEYG PIFRIQTLSD TIIVVSGHEL

 61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA

121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSYYR ETPHPFITSM

181 SRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG NQEENDLLSR

241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR

301 VLTDPTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV

361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKI PHHAYKPFGN GQRACIGMQF ALHEATLVMG

421 MLLQHFEFID YQDYQLDVKQ TLTLKPGDFK IRILPRNQTI SHTTVLAPIE EKLKNDEIEQ

481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE

541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKS DELKGVQYAV FGCGDHNWAS TYQRIPRYID

601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNI EKERSTLSLQ

661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYQ EGDHLGVLPI

721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVS LFDLLSYSVE VQEAATRAQI

781 REMVTFTACP PHKKELELLL EEGVYHEQIL KKRMSMLDLL EKYEACEIRF ERFLELLPAL

841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP

901 QSNFQLPENP ETPIIMVGPG TGVAPFRGFL QARRVQKQKG INLGQAHLYF GCRHPEKDYL

961 YRTELENDER DGLISLHIAF SRLEGYPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK

1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQEEGRYGKD VWAGI

 

>CYP102A10   Erythrobacter litoralis HTCC2594

1 MDAPTALAPI PQPPGKPIVG NAFTVDSSRL IQSLMELAEE YGPIFQLEVM GTPLVFVSGA

 61 DMVAEICDES RFDKTVRGPL KRLRLIAGDG LFTGDTDDPN WAKAHHILLP SFSQKAMGSY

121 LPMMTDIASQ LMLKWERLNS DDVIDVPMDM VRLTLDTIGV CGFGYRFNSF YREDFHPFIE

181 ALNRTLDTTQ KMRGLPGEKL LKRQQIEQLN EDAAYMNNLV DEIIRERRQT GESGQGDLLD

241 FMLSGRDPVT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLQRAYAEVD

301 EVLGRNIDQT PTLSQIGRLP YIRAILSEAL RLWPTAPAMG LAPFEDEVLG GKYAIAKGTF

361 TTVLIPSLHR DKLVWGENPE AFNPDNFSPK AEAARPPHAY KPFGNGQRAC IGRQFAIQES

421 ILVLGMLLQR FELFDHADYQ LRIKETLSIK PDGFTIKARL RHDVERGGVA TVEPESKTPD

481 QAAAVPSHGT PLLVLYGSNL GSSEGFAREL AQRGEFSGFD VTMAPLDAHV AKLPTDGAVA

541 IACASYNGMP PDNAAKFVDW LEQADAADAP LSNVSYLVLG CGNSDWAATF QVVPRKIDAL

601 MEQHGAERLV PAEELDARGD LDTQFHDWLD GLIPQLGDAF DIDLESGFDA VFEPLYTVEI

661 TDSITGNTVA DRVGAREVEV VANRELKDTS KDEGRSTRHL EVRLPEGMEY EPGDHLCVVP

721 VNDPAVVDRL LKRFGLDRDT FVRIESRSDM RGPFPSGSTF SVLNLAETAG ELQAVATRKD

781 IATLARYSEC PNSRAALEAL AAPPSADGTD RYTSEVLEKR RSVLDMLEEF PACDVPLAVF

841 LELIPFLSPR YYSISSAPEA NQGLCSITVG VVKGPALAGT GEFKGTCSAY LADLPPGDRF

901 RAVVRKPTAQ FRLPDNPETP VIMIGPGTGV APFRAFLQRR DHLQEDGAVL GEAMLFFGCR

961 HPDIDYLYRE ELDDYDQRGV ATVHAAFSRH DGSRTYVQDL IAREADRVWE LIEQDARIYV

1021 CGDGARMEPD VRKALMAIYA EKKSSDEASA KAWIDDLVAQ DRYLLDVWVG

 

>CYP102A11   Erythrobacter sp. NAP1

1 MATNATLTPI PQPPGKPLIG NALTVDASQQ IQSLMELAEE YGPIFQLDMM GTPIVIISGA

 61 DLVAEVCDEK RFDKSVRGPL KRLRLIGGDG LFTGDTDAPN WSKAHNILLP SFSQKAMGSY

121 LPMMTDIATQ LVMKWERMNS DDVIDVPKDM IRLTLDTIGV CGFGYRFNSF YREDFHPFIR

181 ALTRTLETTQ KIRGIPGEKL LKGDAVKQLH RDAKYMNNLV DEIIRERQRS GGDGPEDLLD

241 FMLSGRDPLT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLTRAYAEVD

301 TVLGRNIDQP PSLKQIGQLP YIRAILFEAL RLWPTAPAFG LAPFEDEVLG GKYLIPKGTF

361 TTVLIPSLHR DKSVWGENPE VFDPENFTAE AEAARPPHAY KPFGNGQRAC IGRQFAIQES

421 ILVLAMILQR FELFDHSDYK LDIKETLSIK PDEFTIKARM RKDVERGGKA TEDAEEASTE

481 PAEPKVPKHD TPLLVLYGSN LGSSESFARE VAQKGEFSGF EVEMAPLDDY VGKLPEDGAV

541 AIACASYNGM PPDNAAKFID WIEGKDGAAP DLSGVSYMML GCGNSDWAAT FQAVPRLIDA

601 RMEELGAKRI VPTTELDARS DVDTQFHTWL DALMPQLGEH FDLDLSGEAA GIAEPLYKVE

661 VTQSVTANTV ASRVGAHAVK MVANRELKNT DIGEGRSTRH IEVELAQGET YQPGDHLCVV

721 PENDDAVVER LLRRFNLDAD TYVRIESRSE MRGPFPSGST FSVYNLAKTA GELQAVATRK

781 DIATLALYTE CPNSKPALEK LAQPPQEDGT DQYATDVLAK RKSVLDLLED YPACDLPLAV

841 FLEMIPFLSP RYYSISSAPG DTPQTCSITV GVVKGPALSG KGTFKGTCSN YLAELEPGAS

901 FNAVVREPTA NFRLPDDPKV PLIMVGPGTG LAPFRGFLQE RDALASSGEE LGPARLYFGC

961 RTPDEDFLYR DELEDYDKRG IVTLRTAFSR VDEGKCYVQD HIADDADAIW EMLEAGGRIY

1021 VCGDGARMEP DVRAALAKIH SDKTGSTPAE AQSWVGDLIT NERYSLDVWV G

 

>CYP102A12   Rhodopseudomonas palustris HaA2

1 MSSSNKLAPI PHPPKQPVVG NMLSIDTKAP VQHLVRLAEE LGPIFWLDMM GAPIVIVSGY

 61 DLVDEISDEK RFDKAVRGAL RRVRTVGGDG LFTADTSEPN WSKAHNILLT PFGGRAMQSY

121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE

181 SLVRSLETIM MTRGLPLENL WMKKRRDTLA EDVAFMNAMV DEIIAERRKA AAVADKMDML

241 GAMMTGVDKV TGEPLDDVNI RYQINTFLIA GHETTSGLLS CAIYALLKHP EVLQKAYDEV

301 DRVLGADTSV EPSYQQVNQL GYITQILKET LRLWPPAPAY GVAPIQDETI GGQYHLKRGT

361 FTTVLVLALH RDPSIWGPNP DAFDPENFSR EAESKRPANA WKPFGNGQRA CIGRGFAMHE

421 AALALGMILQ RFKLIDHTRY RMVLKETLTI KPEGFKIKVR PRSDKDRATR IASGVSHSVA

481 PAPAAPRARP GHNTPLLVLY GSNLGTAEEL AHRVADLADL NGFATRLGAL DQYVGQLPEE

541 GGVLIFAASY NGAPPDNATQ FVRWLSGDLP PDAFAKLRYA VFGCGNRDWT ATYQAIPRLI

601 DERLAAHGGR NIFVRGEGDA RDDLEGQFEA WFATLGPLAV KEFGIDAAFD RGADDTPLYG

661 IEPLAPAASQ PLAATGVAVA MRVLENRELQ DRAASGRSTR HIEIALPQGM SYRVGDHLSV

721 IPRNDPALVA AVAQRFGFAP DDQIRLSAAP GRRAQLPVGE AVSIGGLLGD HVELQQVATR

781 KQIVALAAHT RCPQTRPKLQ ALAGGDGAAD DAYRAEVLGK RRSVFDLLQE HPACELPFAA

841 YLEMLTPLQP RYYSISSSPA RDPARASVTV AVVEGPALSG RGIYRGACSS WLAGRGSGDT

901 VQATVRATKA CFRLPDDDRV PLIMIGPGTG VAPFRGFLQE RSARKVGGAT LGPALLFFGC

961 RHPAQDYLYA DELQGFAADG IVELHAAFSR GDGPKTYVQH LIAAQKDRVF ALIEQGAIVY

1021 VCGDGGRMEP DVKAALCAIH RERSGADATA AAAWIADLGA RDRYVLDVWA SV

 

>CYP102A12   Rhodopseudomonas palustris HaA2

1 MPSTNKLDPI PHPPKKPVVG NMLSLDTTAP VQHLVRLAKE LGPIFWLDMM GAPLVIVSGY

 61 DLVDEISDEK RFDKAVRGAL RRARAVGGDG LFTADTKEPN WSKAHNILLT PFGGRAMQSY

121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE

181 SLVRSLETIM MTRGLPLENL WMKKRRETLA DDVVFMNAMV DEIIAERRKA SESAADKKDM

241 LGAMLAGVDR ATGEPLDDVN IRYQINTFLI AGHETTSGLL SCAIYALLKH PDVLQKAYDE

301 VDRVLGSDTA VRPSYQQVNQ LSYITQILKE TLRMWPPAPA YGVAPIKDEV IGGKYHLKRG

361 TFVTVLVLAL HRDPAIWGPN PDAFDPENFS REAESKRPAN AWKPFGNGQR ACIGRGFAMH

421 EAALALGMIL QRFQLIDHQR YRMVLKETLT IKPEGFKIKV RPRSDKDRGD FVAAGASQVS

481 TPALAQAAPR ARPDHNTPLL VLYGSNLGTA EELATRVADL AELNGFSTRL GALDQYVGHL

541 PEEGGVLIFT ASYNGAPPDN ATQFVQWLSG DLPKDAFAKL RYAVFGCGNR DWTATYQAIP

601 RLVDERLAAH GGRNIFLRGE GDARDDLEGQ FESWFAKLGP LAVKEFGIDA KFARAVDDAP

661 LYRIEPVAPA AGNAVAAAGG AVPMKVLANR ELQDCAASGR STRHIEIALP EGISYRVGDH

721 LSVMPRNDPA LVAAVAQRLG FAPDDQIKLQ VAPGRRAQLP IGEAISVGRL LGDFVELQQV

781 ATRKQIAVMA EHTRCPQTRP KLQALAGGDG AADEAYRAGV LAKRKSVYDL MQEHPACELP

841 LHAYLEMLSP LAPRYYSISS SPLRDPSRAA ITVAVVDGPA LSGRGHYRGV CSTWLAGRSV

901 GDTIHATVRA TKAGFRLPDD DRVPLIMIGP GTGLAPFRGF LQERAARQQN GATLGPALLF

961 FGCRHPAQDY LYADELQGFA AEGVVELHTA FSRGEGPKTY VQHLIAAQKD RVFTLIEQGA

1021 IIYVCGDGGK MEPDVRAALM AIHRERSGAD AAAASTWIDD LGACNRYVLD VWASA

 

>CYP102A13   uncultured soil bacterium

1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE LGPIFWLDMM GAPIVIVSGY

 61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ PFGNRAMQSY

121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE

181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA TDVAFMNKMV DEIVAERRKS AEASDGKKDM

241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYAIYALLKH PDVLKKAYAE

301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE ALRLWPPAPA YGIAPLKDET IAGGKYSLKK

361 NTFISILVTA LHHDPAVWGP NPDLFDPENF SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM

421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL TIKPDGFKIK VRPRSGHDRT VHAEAATAAV

481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA EDLATRVADL AEVNGFATRL APLDDCAGQL

541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG ELPNDAFAKL RYAVFGCGNR DWAATYQSVP

601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ FESWFAALGA AAVKEFGLES RFSRSADDAP

661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR ELQNKSGPDA SERSTRHIEV QLPGGMTYRV

721 GDHLSVVPCN APALVDRVAR RFGFLPADQI RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL

781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG DDADSSERYR ADILSRRKSV YDLLEEFPAI

841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS RCSITVGVVS CPASSTGRGL YRGVCPYYLA

901 SRREGESVFA TVRETKAGFR LPDDPSVPII MIGPGTGLAP FRGFLQERAA RKAGGATLGP

961 AMLFFGCRHP EQDYLYADEL KAFADEGITE LFVAFSRSEG PKTYVQHLLA TQKARVWDLI

1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC TGADANGGAK WIADLGAQNR YVLDVWAGG

 

>CYP102A14   uncultured soil bacterium             ABD83817

1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE LGPIFWLDMM GAPIVIVSGY  61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ PFGNRAMQSY 121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE 181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA TDVAFMNKMV DEIVAERRKS AEASDGKKDM 241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYAIYALLKH PDVLKKAYAE 301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE ALRLWPPAPA YGIAPLKDET IAGGKYSLKK 361 NTFISILVTA LHHDPAVWGP NPDLFDPENF SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM 421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL TIKPDGFKIK VRPRSGHDRT VHAEAATAAV 481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA EDLATRVADL AEVNGFATRL APLDDCAGQL 541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG ELPNDAFAKL RYAVFGCGNR DWAATYQSVP 601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ FESWFAALGA AAVKEFGLES RFSRSADDAP 661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR ELQNKSGPDA SERSTRHIEV QLPGGMTYRV 721 GDHLSVVPCN APALVDRVAR RFGFLPADQI RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL 781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG DDADSSERYR ADILSRRKSV YDLLEEFPAI 841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS RCSITVGVVS CPASSTGRGL YRGVCPYYLA 901 SRREGESVFA TVRETKAGFR LPDDPSVPII MIGPGTGLAP FRGFLQERAA RKAGGATLGP 961 AMLFFGCRHP EQDYLYADEL KAFADEGITE LFVAFSRSEG PKTYVQHLLA TQKARVWDLI 1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC TGADANGGAK WIADLGAQNR YVLDVWAGG 

 

>CYP102A15   Bacillus pumilus ATCC 7061             ZP_03053227

1 MQQTSIIPKP KTYGPFKNIP HIKKGELSQT FWRLADELGP IFQFEFSKAT SIFVSNHELF   61 QEICDESRFD KYIGTSLNKV RAFAGDGLFT SWTEEPNWRK AHHILMPAFS QQAMKGYHEM  121 MLDIATQLVQ KWQRTGRDEE IEVAEDMTKL TLDTIGLCGF DFRFNSFYKE NQHPFIESMV  181 NGLSEAMDQA SRLPVADKLM IKRRKKFEEN VDFMKQLVDD IIQERKKQDK TGDDLLSLML  241 HAKDPETGER LSDENIRYQI ITFLIAGHET TSGLLSFAIY FLLKNPEKLK KAVQEADDVL  301 QGGLPTFKQV QKLNYTRMVL NESLRLWPTA PTFSLYAKED TVIGGKYSIE KNQSVSVLLP  361 KLHRDQAVWG EDAEEFKPER FLHPEKIPQH AYKPFGNGQR ACIGMQFALH EATMVLAMVL  421 HNLELIDHTS YELDLKESLT IKPNDFKIKV RPRKQQLFMV PPKEETKKST TTDESKVKSH  481 GTPLLVLYGS NLGTAQQIAN ELAEEGKAKG FDVTTAPLDD YTRQLPDKGA VFIVTASYNG  541 HPPDHAKKFV DWVTQEKEQD LTNVTFAVFG CGDRNWASTY QRIPRLIDEA LERKGAKRAA  601 DLGEGDAGGD MDEDKEAFQK TVFKQLAKEF QLTFQEKGKE NPKLSVAYTN ELVERPVAKT  661 YGAFSAVVLK NEELQSEKSE RQTRHIELQL PEGKKYKEGD HIGIVPKNSD ALVQRVINRF  721 NLDPKQHIKL YSEKKANHLP LDQPIQMREL LASHVELQEP ATRTQLRELA AYTVCPPHRV  781 ELEQMAGEAY QEAILKKRVT MLDLLDQYEA CELSFVHFLA LLPGLKPRYY SISSSPKVDE  841 KRVSITVAVV KGKAWSGRGE YAGVASNYLC GLKEGEEVAC FLHEAQAGFQ LPPSSEVPMI  901 MIGPGTGIAP FRGFVQAREV WQKEGKPLGE AHLYFGCRHP HEDDLYFEEM QLAAQKGVVH  961 IHRAYSRHKE QKVYVQHLLK EDGGMLIKLL DQGAYLYVCG DGKVMAPDVE ATLIDLYQHE 1021 KQCSKEAAEN WLTTLANNNR YVKDVWS 

 

>CYP102B1    Streptomyces coelicolor cosmid F43.

MAQTAREPARDGLPKGFRSAELGWPELHRIPHPPYRLPLLGDVV

GASRRTPMQDSLRYARRLGPIFRRRAFGKEFVFVWGAALAADLADEARFAKHVGLGVA

NLRPVAGDGLFTAYNHEPNWQLAHDVLAPGFSREAMAGYHVMMLDVAARLTGHWDLAE

ASGRAVDVPGDMTKLTLETIARTGFGHDFGSFERSRLHPFVTAMVGTLGYAQRLNTVP

APLAPWLLRDASRRNAADIAHLNRTVDDLVRERRANGGTGGGTGSGSGSGDLLDRMLE

TAHPRTGERLSPQNVRRQVITFLVAGHETTSGALSFALHYLAQHPDVAARARAEVDRV

WGDTEAPGYEQVAKLRYVRRVLDESLRLWPTAPGFAREAREDTVLGGTHPMRRGAWAL

VLTGMLHRDPEVWGADAERFDPDRFDAKAVRSRAPHTFKPFGTGARACIGRQFALHEA

TLVLGLLLRRYELRPEPGYRLRVTERLTLMPEGLRLHLVRRTAAAPAPGRRTAAPGAA

DDAGDTVSAPGCPVHRAGD

 

>CYP102B2   Streptomyces avermitilis

MAQSTRTVIPKGFRSAELGWPELHRIPHPPHRLPVVGDVLGVNV

RTPVQDSLRIGRRLGPVFRRKAFGKEIVFVGGADLAAELADESRFAKHVGLGVANLRP

VAGDGLFTAYNHEPNWQLGHDVLAPGFSREAMAGYHPMMLAVTERLIDHWDREQTAGR

AVDVPGDMTKLTLETIARTGFGHDFGSFERARPHPFVTAMVGTLTYAQRRNVVPEPLA

PLLLRTATRRNAADLAYLNRTVDALVRARRTTSGEGDLLDRMLDTARPGTGERLAPEN

IRRQVITFLVAGHETTSGALSFALHYLSRHPDVAARARAEVDRVWGGTARPGYDQVAK

LRYVRRVLDESLRLWPTAPAFAREARRDTVLGGVHPMREGAWALVLTAMLHRDPGVWG

ADAERFDPDRFDAQAVRSRAAHTFKPFGTGARACIGRQFALHEATLVLGLLLRRYELR

AEPGYRLRVAERLTLMPEGLRLRLDRRVPAVEDVPVANPEVSSGPRCPVTGAGE

 

>CYP102B3    Rhodococcus sp. RHA1 Rha05872

MPVTVLLDTGSVRGTLRTRHQFSNAGHIDTGVDMSVESLHTTADATIPHPRWRLPVVGDVFGISIRTPLQNSMEIGRKLGPIFERNVLGNRFVFASGADMVAELSDESRFAKHLAPGVASLREVGGDGLFTAYNHEPNWSKAHNLLAPAFTKSAMRSYHRTMLDVAGELTEHWDERVDGSPVDVSSDMTKLTLETIGRTGFSYSFDSFGRERPHPFVQAMVGALSHSQRTTFVKSSALGRLLMRRSDRRNIANLEHMAEVVDEVIRARRDSAEDGPEDLLELMLRAARENDPHRIDELNIRHQVVTFLVAGHETTSGALSFALYYLSRHPDVLAKAQAEVDAVWGDEEPAFEQIAKLRYVRRVLDESLRLWPTAPAYGREATVDTTLVGKYPMKVGDWVLVLIPALHRDPVWGDDPEAFDPDHFLPERIRSRPAHVYKPFGTGERACIGRQFALHESVLVLGTILRRYDIVGDPDYRLKVAERLTLMPEGFTLQLRRR

 

>CYP102B4    Streptomyces scabies SCAB9321 

MTATTAATAI SGFRSAELGW PELHRIPHPP FRIPLLGDVL GTNVRTPVQE STRLGQRLGP

IFRRKAFGKE IVFVGGAELA AEMADEARFA KHVGVGVANL RPVAGDGLFT AYNHEPNWQL

AHDVLAPGFG REAMAGYHPM MLDVAERLIE HWDREETAGS AVDVPGDMTK LTLETIARTG

FGHDFGSFER TRPHPFVAAM VGTLTYAQQR NVVPDPLVPV LLRGAAQQNR ADMAFLVETV

DAVVRARRSP GGGRGAGDGD LLDRMLETAH PETGERLSAE NVRRQVITFL VAGHETTSGA

LSFALHYLAR YPDLAARARA EVDRVWGDAA RPGYEQVAKL RYVRRVLDEA LRLWPTAPAF

SREAREDTVL GGVHPMRRGA WALVLTSMLH RDPEVWGADA ERFDPDRFDA AAVRGRAPHT

FKPFGTGARA CIGRQFALHE ATLVLGLLLR RYELTPEPGY RLRVVERLTL MPDGLRLRVR

RRAGAGTDAP RTPSSPPTPS SAPSGRPVTG AGE

 

>CYP102C1    Rhodococcus sp. X309

AAAGGKIDATADANKLALDVIGLAGFGYDFASFDGDEHPFVGAM

SRVLEHVNRTSNDIPFLRKLRGNGADLQYEKDIAFVRTVVDDVITERQAKPGEHQDDL

LDLMLNNIDDETGEKLDPVNIRNQVLTFLVAGNETTAGAIAFALYFLSRHPEIADAAR

AEVADITGGETPAFEDVARMRYLRRVVDETLRLWPSAPGYFRKVRTDTTLGGRYAMPK

GSWVFVLLPQLHRDPVWGENPDSFDPDRFKPENVKKRPAHAYRPFGTGPRSCIGRQFA

LHEAVLSLATILQRYSFQSDPEYKLDVREALTLKPVGLELSLQRL

 

>CYP102C2   Rhodococcus erythropolis PR4

1 MNGPRGSRTR PRRASLVNLA VLGVVLVHTV LMSADKCPYP KSATRAGEIT AVQPQVFESI

 61 PSPAWRLPLL GDLLTVDSEK PIQKEMALAS KLGPIFEWKI VNNRVTVVSG VDLVAEVNNE

121 ALWAKSVGLP ILKLRKVAED GLFTAFNSEP NWRKAHNILS EGFSRSALRN YHPSMLRALG

181 GLTDSWDRVA DAGETIDASS DANKLALDVI GLAGFGYDFA SFIGEEHPFV GAMSRVLAHV

241 NSTSNDIPFL RKLRGNGADL QNEKDIALLR TVVDNVIAER QSKPGEHQDD LLDLMLHSAD

301 AETGEKLDPV NIRNQVFTFL VAGNETTAGT LAFALYFLSR HPDVADTARA EVADVTAGET

361 PAFEDVARMR YLRRVVDETL RLWPSAPGYF RKVRTDTTLG GRYDMPKGSW VFVLLPQLHR

421 DPVWGEDPES FDPDRFKPEN VKKRPAHAYR PFGTGPRACI GRQFALHEAV LALAIILQRY

481 NFQSDPEYKL DIRETLSLKP VGFELSLQRR

 

>CYP102D1   Streptomyces avermitilis

MTTQPETDLRPIRSPRGVPLFGHTPQIPSTNPVEYFGKLSKQFP

EGLYGMEIAGIEQVFVWDPDLVAEVCDETRFFKQIDKTPLAHVRDYAGAGLFTAHQHE

EEWGMAHRVLLPVFSQRAMKGYFGQMLEIAQNLVGKWERKEGQPVNITDDYTRLTLDT

IALSGFGYRFDSFAKEDLHPFLNALLQALVESLRRSQELPVMTKMRKADDKKYRENIR

LMRDLVENVIKERREGKGTGEDDLLGLMLEATDPETGKGLDDDNVRDQVVTFLIAGHE

TTSGLLSFATYSLMRNPHILAQAYAEVDRLLPGDTVPDYDTIMQMDVIPRILEETLRL

WAPIPMIGKSPLEDTVIGGCYGLKKGARVNILEGPLHTHPKAWERPEEFDINRWLPEN

RVNHHPHAYKPFGNGVRACIGRQFALTEARLALALVLQKFKFADTDDYKMDVKEALTR

KPGGFELNVRARQEHERTVFGAAD

 

>CYP102E1    Ralstonia metallidurans

MSTATPAAALEPIPRDPGWPIFGNLFQITPGEVGQHLLARSRHHDGIFELDFAGKRVPFVS

SVALASELCDATRFRKIIGPPLSYLRDMAGDGLFTAHSDEPNWGCAHRILMPAFSQRAM

KAYFDVMLRVANRLVDKWDRQGPDADIAVADDMTRLTLDTIALAGFGYDFASFASDELDP

FVMAMVGALGEAMQKLTRLPIQDRFMGRAHRQAAEDIAYMRNLVDDVIRQRRVSPTSGMD

LLNLMLEARDPETDRRLDDANIRNQVITFLIAGHETTSGLLTFALYELLRNPGVLAQAY

AEVDTVLPGDALPVYADLARMPVLDRVLKETLRLWPTAPAFAVAPFDDVVLGGRYRLRKD

RRISVVLTALHRDPKVWANPERFDIDRFLPENEAKLPAHAYMPFGQGERACIGRQFALTE

AKLALALMLRNFAFQDPHDYQFRLKETLTIKPDQFVLRVRRRRPHERFV

TRQASQAVADAAQTDVRGHGQAMTVLCASSLGTARELAEQIHAGAIAAGFDAKLADLDDA

VGVLPTSGLVVVVAATYNGRAPDSARKFEAMLDADDASGYRANGMRLALLGCGNSQWATY

QAFPRRVFDFFITAGAVPLLPRGEADGNGDFDQAAERWLAQLWQALQADGAGTGGLGVDV

QVRSMAAIRAETLPAGTQAFTVLSNDELVGDPSGLWDFSIEAPRTSTRDIRLQLPPGITY

RTGDHIAVWPQNDAQLVSELCERLDLDPDAQATISAPHGMGRGLPIDQALPVRQLLTHFI

ELQDVVSRQTLRALAQATRCPFTKQSIEQLASDDAEHGYA

 

>CYP102F1   Actinosynnema pretiosum subsp. auranticum

MVATGTRIPGPKPLPLVGNLLDVLTSDLDTDVDFLDRCHREHGG

IVALTFAGQRQVFASSHELVARMCSDPSWGKAVHPALEQVRDFAGDGLFTARGDEPNW

GKAHRLLMPAFGPTAMRDHFPAMLDIAEQMLVRWRRFGPDHRIDVADDMTRLTLDTIA

LCAFGARFNSFYRDRAHPFVDAMVRSLVEAGERAERLPGVQPFLVGRNQRYRDDIATM

NRIADGIVAARAALPAGERPDDLLERMLTCADPVTGERLSARNVRYQLATFLIAGHET

TSGLLSFAVHRLLAHPEVLRKAKDAVDGVLGDRVPAFEDLARLDYLGQVLRETLRLHP

TAPAFALAPDEPAELGGHAIGAGEPVLVMLPTLHRDPAVWRDPDVFDPERFAPERMDE

IPACAWMPFGHGARACIGRPFALQEATLVLALVLQRFDLALADPDHRLTIKQTLTLKP

DSLVVRARPRADRPGATATVETVVPHQVPATHRHGTPLHVFYGSNGGSGEGLARTIAG

DGAARGWATSVAPLDDAVRALPASGPVVIVSSSYNGAPPDNAAHFVRWLTQDGPDLSG

VDYLVLGCGNLDWSATYQRVPTLIDEAMAAAGARRLRERGATDARADFFGDWERWYEP

LWPLLSAECGVEVGEIGPRFRVVESDAADGLGDLASAVVLENRELVRGPDAGSKRHLE

LRLPDGTSYRTGDYLSVLPQNHPDLVRRAVARLGTRAERVVTVESSAPTGLVPVGRAL

RVDELLTRCVDLSAPAGAGVVARLAERCPCPPERAELAATTGATLLELLERFPSCAVD

LALALELLPAPRTRLYSISSAAEEQRAEVALTVSVTGVTSGYLSRVRPGDRVAVGIAS

PPESFRPPADNTVPVVLIAAGTGIAPFRGFLRARAALGGEPGPALLLFGCRGPELDDL

YAEEFAALGDWLEVDRAYSRHPDGEVRHVQHRLWQRRDRVRELVDAGARVYLCGDATR

VGPAVEEVLGRIGPGAGWLDALRAGGRYATDVF

 

>CYP102G1    Streptomyces scabies SCAB5931 

MTHATERGTE SIPERSALPL VGHAFDIPGG ADGLLHLMKE ARELGPLFKL RVFGNEINIA

SGLDLVTELS DESRFRKNVH ADLVLVREIT GDGLFTAFND EPNWRKAHDV LMPAFSLGAM

RGYHATMLKV ARELIGKWDG AAGTEPVDVA EDMTRLTFDT IGLCGFGHDF ESFGRPEPHP

FVTALSRALG FAQAKGESIP GLDLFKWKQA EQFRTDVAVM RDLVDDVIRE RRASGDTGTD

DLLGRMLHTR DQVTGEPLDD VNIRHQAITF LIAGHETTSG ALSFALYYLT KHPEVLARAQ

AEVDALWGDT DTPDPDYGDI GKLTYIRQVL NEGLRLWPTA PAYAVEPLED TVIGGRYAVR

EGETIQVLIP QLHRDPAWGE NVELFDPDRF LPEREQERPV HLFKPFGSGE RACIGRQFAL

HEATLVLALV IHRYRLIDHT DYQLKIKQSL TIKPDEFTLR LARRTAGERR LPLVASDRAP

AGEAPPAVRR AAGTTLTLLH GSNLGTCAGI ARELAEDGEQ HGFAPTVASL DSAAGTLSAV

DGPVVIVAAS YNGRPTDDAT RFMEWLDDLA PGSLDGLRYA VLGVGDRNWA ATYQRVPALI

DERLSAAGAT ALLERGAADA SGDFAGTVDR WTGELWTTLL DRHGTAQDGV AAQPDTDAEG

GLYVLEDTTD SVIGGLAARH GVQPMEVLDA RELVDMSHGL GRSKRFLRLR LPEGVTYRTG

DHLAVLPRNP DHLVRRVTDR FGLDPDRTVR LRARRRGRNT LPVDRPLTVR RLLTDFVELQ

DPATREQIAV LAEHTACPPE KRPLTELAAA DPETFREQVT AAGRSVLDLL ERHRACELPF

ERFLELLPVL RPRPYSISSS ALAAPGEVDL MVSLLAAPHR AGEGMFHGIG SHFLQTVRPG

DTLQARVLPC SEAFRLPDDT SASVILVSAG TGLAPFRGAV LDRRHAGSTG TLLCYFGCDH

PDVDYLHRAE FEAAEAAGAV SMRPAFSCAP EDGVRFVQDR IGKESDEVWA ALEAGARVHV

CGDGRRMAPA VREAFRALYR ENTGADDAEA TAWLDALTES GHYVEDVWAG

 

>CYP102G2    Saccharopolyspora erythraea NRRL23338

MTQTPLHHDDVPVADVSGTGLTATPTQQAMELARRHGPVFRRRTREFQSLLVSDVDLVAE

LSDEQRFAKAVGPALENVREFAADGLFTAYNDEFNWAKAHDILMPAFALGSMRTYHPVML

RVARRLLDSWDRAAAASAPVDVPDDMTRMTLDTIGLAGFGFDFGSFGRAEPHPFVGAMVR

CLDWSMTRLSRVPGTDHSERDEAFRADARYLASVVDEVINTRAAEGDTSGEDLLGLMLGA

RHPADGTTLDAANIRNQIITFLIAGHETTSGTLSFALHYLAKNPTVLRLVQREADELWGD

SPDPEPSFEDIGRLTYTRQVLNETLRLWPSAPAFGRQARHDTVLGGRIPMRAGEAAAVLI

PMLHRSPVRGDNPELFDPARFAPEAEAARGPHAFKPFGTGERACIGRQFALDEATMVLAM

LAHRYRLVDHAGYRLKVKETLTLKPEGLTLAVRARTAADRVTNRLALPVGLPSAAPGEPA

DAARRPGRVLPGTGLLLLHGSNYGTCRDFAAQLALAAGELGCDTAVAPLDEYAGNLPSDR

PVIVVAASYNGRPTDDAVSFSRWLDEAEPGAADGVDFAVLGVGDRNWAATYQHVPTRIDA

RLAELGGTRILERGEADASGDLAGAVRRFSAALETALLERSGDPDAVAAAPEGDGPAYTV

SEVTGGALDSLAARHGMVEMTVTEVADLTAPDYPRTKRFVRLALPEGTAYRTADHLAVLP

VHDAALVERAAGVLGVDLDTVLDIRAKRPGRLTFDRSLTVRELLSHHVELQDPPTPDGLD

ALAALNPCPPERAALRGLAEEARSGTADHRTLWDLIEDHPALRDALSWSALLELLPATRP

RQYSVSSSPAVDPRHVDLMVSVLRAPARSGRGEFRGAGSRHLSEVRPGDTVLARVQPCRE

DFRVAPDEPLIMVAAGTGLAPFRGVIADRRERVANGARQAPALCYFGCDAPDADYLHSAE

LRAAESAGAVAMRPAFNEAPVGGQCFVQHRIAAEAGEVWALLESGARVLVCGDGRHMAPG

VREAFRGIYRERTPGADDASAHEWLQAMIAGGCYVEDVYAG

 

>CYP102H1    Nocardia farcinica IFM 10152 plasmid pNF1

MAVTTSTTSGGHSNPPLPHPKWRLPIINDLLTINPIKPTLTSLR

DAEQLGGIFERRLVDWPMIVVSDSELITEICDERNWAKHLGVPLRKMRHIARDGLFTA

RNDEPNWAKAHAVLAPAFTKEAMRSYHQTMLTTIGELLDYWAKRDGQWVDVGEDMNKL

TLEIIARTGFDYTFDSFTRSEVHPFVAAMLRGLTYISRNSNMPPFLQKTIGARAAARH

SRDITYVRTVVDDVIKARQASGTVGDHHDLLDRMLTVPDPASDELLDTTNVRSQILTM

LVAGHETSAGVLAFALYELSRRPELVAAARAEIETRFADGDLSTIAYDDVAKLRTLRR

IVDETLRLYPVAPGFFREARHETTIGGGRYRFGPGDWVLVLTLHAHRDPATWGPDAGE

FQPDRWLPERMRSLDGRQVFKPFGTGLRACIGRQFAYHEIVLALAHILHTFEFTPDPG

YELDIAEQITLKPHRFRLRLNHR

 

>CYP102J1 Burkholderia sp. 383 ABB05850 50% to CYP102A4   

1 MKSSSLVPQP PLKPVIGHLM EVLGPSPLAK MMDLARTYGP VYWFEVFGQG YYVVSGQTLV  61 DEVCDETRFQ KCVHQSLLEL RPAIGDGLFT AFGDEPNWAK AHRVLMQAFG PLSIWSMFDK 121 MVDIADQMFL HWERFGPETP VDVSDHMTRL TLDTIALCAF DCRFNSFYRE DQHPFVDAMV 181 NTLSEAGKRE LRPKLVSKLM VKRSRQFDAD IEVMRSLATK MIEDRRKNPH VNEESMDLLD 241 RMLNGIDPVT GEKLDDENIV FQMITFLIAG HETTSGLLSF ATYFLLKNPD ILQKARDMVD 301 EVVGSETPRI EHLARLRYVE QILMETLRIW PTAPGFAVKP LADTTFGGKY AVSPDDIIMI 361 LTPMLHRDVS VWGEDVEAFR PERFAPENAE QLPPNSWKPF GNGARACIGR PFAMQEAHLV 421 LIMLLQRFDF SFADPDYELD VAETLTLKPA GFRVNVKPRA RGALKVPDTA LHARSNAQSP 481 SVAPVQSIAP GEDLSNLLVL FGGNTGSAES FARRIAGDAS RHGFHATCAP LDDFAGKLGG 541 YPAIVIVTAS YEGQPPDNAK SFVPYVEALD EGALDGVHFS VLGCGNKQWA RTYQAIPKRV 601 DEALEKAGAT RVHFRGELDS GGDFFGEFDR WYTEMWNRFA ISAGKEIPVI QHDDVALKVS 661 FAGSSREKVL NLGDMAHASI VDNRELVDIS VAGSRSKKHI ELKLPEAMTY RSGDYLAVLP 721 RNAKNNVDRV LRRFRVSWDT QVVIEGTSSN PRLPLGQAIG CGELFSSYVE LAVPATRSQV 781 SSLAAATRCP PEKVELERLS ADGFECEILG KRTTVMDLLE RFGSVDLSLE KFLDMLPALK 841 ARQYSISSSP LWKADHVTLT VAVVDAPALS GNGRHEGVAS SYLARLNTGD SLSVAVRPSN 901 ARFRPPAEPD LPMILICAGS GIAPFRGFLQ ERALQKQRGE NVGTSLLFFG IDDPDVDFLY 961 RDELDEWARC GVVEVMPAYS NRPEEGARFV QDKVWLERER ISALFSQGAT VFVCGDGKNM 1021 APAVRATLGR IYQETTGEND ESASAWIDTM EREHGRYVAD VFA

 

>CYP103A1     Agrobacterium tumefaciens

MIANSSTDVSVADQKFLNVAKSNQIDPDAVPISRLDSEGHSIFA

EWRPKRPFLRREDGIFLVLRADHIFLLGTDPRTRQIETELMLNRGVKAGAVFDFIDHS

MLFSNGETHGKRRSGLSKAFSFRMVEALRPEIAKITECLWDDLQKVDDFNFTEMYASQ

LPALTIASVLGLPSEDTPFFTRLVYKVSRCLSPSWRDEEFEEIEASAIELQDYVRSVI

ADSGRRMRDDFLSRYLKAVREAGTLSPIEEIMQLMLIILAGSDTTRTAMVMVTALALQ

NPALWSSLRGNQSYVAAAVEEGLRFEPPVGSFPRLALKDIDLDGYVLPKGSLLALSVM

SGLRDEKHYEHPQLFDVGRQQMRWHLGFGAGVHRCLGETLARIELQEGLRTLLRRAPN

LAVVGDWPRMMGHGGIRRATDMMVKLSFDL

 

>CYP103A2     Agrobacterium tumefaciens

MITSSISGTDQQFQNATQPKELDPDAVPVSRLDSEGHEIFAEWR

PKRPFLRREDGVFLVLRADDIFLLGTDPRTRQIETELMLNRGVTRGAVFDLIRYSMLF

SNGEVHVKRRSAFAKTFAFRMIDALRPEITKLTEHLWDDVPRVDDFDFAEMYASKLPA

LTIASVLGLPFGDAPFFTRLVYNVSRCLSPSWGEDDFPEIEASAVELQDYVRAVVADR

SRRISDDFLSCYLKAVREEGTLSPIEEIMQLVFLILAGSDATRNAMVMLPTLLLQNPV

VWSSLCHDQSGVAAAVEEGLRFEPSVGSFPRLALEDIDLDGYVLPKGSFLALSIMSGL

RDERHYEHPQLFDIKRKQMRRHLGFGAGVHRCLGEALARIELQEGLRTLLRRAPSLRV

TGDWPRMIGHGGARRATGMTVNLGVDR"

 

>CYP103A3   Agrobacterium tumefaciens plasmid pTiAB2/73 vir

MNARGPEKVSQTSGPIISASLDPDNVSVSDLDRSGHAIFAEWRP

KRPFLRRQDGVYVLLRADDVLGLSSDPRTRQIETELMLNRGINEGAVFDFVRYSMLFS

NNEVHSRRRSPFTRTFAFRMIENLRPQVSQLTETLFQDLKELDSFNFVEEFASKLPAV

AIAGLLGLPPSDIPYFTQLVYRVARCLSPSWRDADLPDIEASAAEFKNYVQAVIDDRR

SNPRDDFLSSFIRATREAEDLSPDEGLAQLMLIVLAGTDTTKTGLTALTGQLLRHRHV

WEALLKDESLVPAAVEEGLRFEPPVGSYPRLALADIDLEGFILPKGSLLALCTMSALR

DEKHFAHPELFDIHRKQMHWHMVFGAGAHRCLGEALARLELQEGLATVLRYAPTLSIE

GEWPTVQGHGGVRRIAEMRVGFRRQI

 

>CYP104A1     Agrobacterium tumefaciens

MEERRVSISSITWRFPMLFAPVDDVTTIDDLTLDPYPIYRRMRV

QNPVVHVASVRRTFLTKAFDTKMVKDDPSRFSSDDPSTPMKPAFQAHTLMRKDGTEHA

RERMAMARAFAPKAIADHWAPIYRDIVNEYLDRLPRGDTVDLFAEICGPVAARILAHI

LGICEASDVEIIRWSQRLIDGAGNFGWRSELFERSDEANAEMNCLFNDLVKKHRSAPN

PSAFATMLNAPDPIPLSQIYANIKIAIGGGVNEPRDALGTILYGLLTNPEQLEEVKRQ

QCWGQAFEEGLRWVAPIQASSRLVREDTEIRGFIVPKGDIVMTIQASANRDEDVFEDG

ESFNVFRPKSAHQSFGSGPHHCPGAQISRQTVGAIMLPILFDRFPDMILPHPELVQWR

GFGFRGPINLPVTLR

 

>CYP104A2    Agrobacterium tumefaciens

MQLAPVDRVTTIDDLTLDPYPIYRRMRAQTPVVRVASVMRTFLT

KASDTKMVKDQPRRFSSDDPNTPMKPAFQAHTLMRKDGAEHARERMAMAKAFAPKTTA

EHWAAIYRDIVNEYLDRLSRGSTVDLFAEICGPVAARILAHVLGISEASDAEMIRWSQ

RLIEGAGNFGWRPEPFERANEANAEMNRLFDNLVEKHRAEPNPSAFAIMVTASDPIPM

SQIYANIKIAVGGGINEPRDALGTIIYGLLTNPEQFEEVKRQQCWGQVFEEGVRWVAP

IQASSRLVLEDTEIRGFLVPKGDTVMTIQASANRDEDVFDDGERFNVFRQNNAHQSFG

SGPHHCAGAQISRQTVGAIMLPTLFERFPNMTLTNPDAVQWRGFGFRGPISLPVTLI

 

>CYP105A1    Streptomyces griseolus

MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVT

LYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPE

HGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVIC

RLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGA

LVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSL

VPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPD

ALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRP

GTTIQGVNELPVTW

 

>CYP105A2    Amycolata autotrophica

MTTDATDPRTTDAAPFPSNRSAPYRFSDGYAQLRDPPGPLRLGT

RYDGRQAWVVVIHEAARKLLASRFESADAHRTGFPFLTAGGRDMIGTNPTLFRMDDPE

HARLRRMTISHYTVKRIKTISEFVEEVVLVFLRRMTISGPTADLVSQFLIGAGHMVIC

RLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLQYLARLARTKRERPDDAIIS

RLVARGEILREEDISDAMLLLIAGHATDANLTSMSLYALADRSEQYAALRADRSLVPG

AVEDPLRYVAIADIATEDVPIRGRTIAAGNTQIAMGSSANLDHEYYEDPDALTARVED

LVHLAFGFGRHQCLGQNLARADQLREDLMTARNDPTLRLAVPVQSSARLEGTTIQGVN

ELPVTW

 

>CYP105A3    Streptomyces carbophilus

MTEMTEKATTFLTSQEAPAFPADRTCPYQLPTAYSRLRDEPDAL

RPVTLYDGRRAWVVTKHEAARRLLADPRLSSDRLHADFPATSPRFKAFRQGSPAFIGM

DPPEHGTRRRMTISEFTVKRIKGMRPDVERIVHGFIDDMLAAGPTADLVSQFALPVPS

MVICHMLGVPYADHEFFQDASKRLVQAVDADSAVAARDDFERYLDGLITKLESEPGTG

LLGKLVTHQLADGEIDRAELISTALLLLVAGHETTASMTSLSVITLLEHPDQHAALRA

DPSLVPGAVEELLRVLAIADIAGGRIATADIEIDGQLIRAGEGVIVTNSIANRDSSVF

ENPDRLDVHRSARHHLSFGYGVHQCLGQNLARLELEVILTVLFDRIPTLRLAVPVEQL

TLRPGTTIQGVNELPVTW

 

>CYP105B1    Streptomyces griseolus

MTTAERTAPPDALTVPASRAPGCPFDPAPDVTEAARTEPVTRAT

LWDGSSCWLVTRHQDVRAVLGDPRFSADAHRTGFPFLTAGGREIIGTNPTFLRMDDPE

HARLRRMLTADFIVKKVEAMRPEVQRLADDLVDRMTTGRTSADLVTEFALPLPSLVIC

LLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLEYLARLARTKRERPDDAIIS

RLVARGELDDTQIATMGRLLLVAGHETTANMTALSTLVLLRNPDQLARLRAEPALVKG

AVEELLRYLTIVHNGVPRIATEDVLIGGRTIAAGEGVLCMISSANRDAEVFPGGDDLD

VARDARRHVAFGFGVHQCLGQPLARVELQIAIETLLRRLPDLRLAVPHEEIPFRGDMA

IYGVHSLPIAW

 

>CYP105B2    Streptomyces tubercidicus strain R-922

MTTAERTEAERNTGSTGPSEDLAPLSPLAVPAARADGCPFDPAPGVERARREEPVTRATLWDGSTCWLVTRHQDVR

EVLGDPRFSADAARPGFPFLTAGGRVLATSKPTFIRQDDPEHARLRRMLTADFMVKKMEAMRPEVQRLADDLLDRM

TAGRNAADLVAEFALPLPSLVICLLLGVPYDDHEFFQDRSRLLLSLRSTAEEVRTAQADLQRYLSRLAAAKQREPD

DGIVSRLVARGELDFEEIASMGRLLLIAGHETTANMTALSTLALLRNPGQLARLREDPSLIKGAVEELLRYLTIVH

NGLPRVATEDVTLGGRTIRAGEGVLCTLNSANRDEDVFPGGDALDVGRDARRHVAFGFGVHQCLGQPLARVELQIA

VETLLRRLPDLRLGIPFEDVPFRHDMGIYGVHALPVAW

 

>CYP105B3    Saccharopolyspora erythraea NRRL23338

MTSTLDESTPDYPMPRARGCPFDPPPALRDLQRETPMARVRLWDGSTPWLVTRYADQRAV

LRDSHVSADMNHPTYPRQAPGGGTLSFIGMDDPEHARLRRMVGSAFAVKNVERMRPWVQR

IVDEAVDELLAGPRPADLVEEFALPVPSLVICGLLDVPYADHAFFQSNSKTMINRDSTPE

QRSQASGRLAEYLSDLLSSKMDTRGDDLRSRLCGRIEAGDLTLRQATEMAVLLLIAGHET

TANMIALSTLLLLRHPDQLALLRESDDPDVARRAVEEMLRYLNITHGGRRRVALEDVEVA

GQRVRAGEGLVLPNEIANRDPDAFPDPDRLDITREARHHVAFGFGVHQCLGQPLARLELE

IVYRTLYRRAPRLALAAGIEDIPFKHDGFVYGVYELPVTW

 

>CYP105B4 SBI_7395 Streptomyces bingchengensis

59% to CYP105B3 Saccharopolyspora erythraea NRRL23338 

VTGAAANTTSGTPLDTPEYNIDRSARCPLDPAPAMRARQAEGPLVRVRLW

DGTLAWLVTGWEEHRALMSDQRVSVDPFRPGAPKLSPGEVTAIDVLKKEG

KRSTGTSFILMDDPEHARLRRMVTSAFTIKRVEALRPPTQRITDDLIDTM

LAGPKPVDLVEALALPVPSLVISNLLGVPYDDHEFFQANSRTIINRETTA

AERAAARGRLVDYLDGLLGEKLAQPREDLLSGLAERIKTGELAREDATEM

GVLMLFAGHETTANMITLGTLALLQHPDQLALLRDTEDPKLIASAVDELL

RYLTITHGGQRRVALADIEIAGQVIRAGEGVIPVNEIANRDPSVFPDPDR

LDLRRDARRHVAFGFGIHQCLGQPLARMELQVVYPTLLRRIPTLALAADL

AEIPFKHDGFVYGAYRLPVTW

 

>CYP105C1    Streptomyces sp.

MTQAAPVTFSTVRENYFGPPAEMQALRHKAPVTRTAFADGRPGW

LVTGYSAARAVLSDSRFTARGEREHPAVPRAATLEDERCRRLIAGQFTARRMRQLTGR

TERIVREHLDAMEHMGSPADLVEHFALPVPSLVIAELLGVPPPDREHFQHDTLRWGGF

GRSTEEVTEAFVSLGGQLQRLVRLKRTEPGDDLLSGLIAADPALTDEELASIAFLLLV

AGHGTTAHQIALGAFLLLEHPDQLAALRADPALTESAVEELLRHLSVVHHGPTRAALQ

DADIEGTPVKAGEVVVVSLGAANRDPARFERPDAVDVTREDTGHLAFGHGMHQCLGRQ

LARIELRVALTALLERFPHLRLACPAAEIPLRHDMQVYGADRLPVAW

 

>CYP105D1    Streptomyces griseus

MTESTTDPARQNLDPTSPAPATSFPQDRGCPYHPPAGYAPLREG

RPLSRVTLFDGRPVWAVTGHALARRLLADPRLSTDRSHPDFPVPAERFAGAQRRRVAL

LGVDDPEHNTQRRMLIPTFSVKRIGALRPRIQETVDRLLDAMERQGPPAELVSAFALP

VPSMVICALLGVPYADHAFFEERSQRLLRGPGADDVNRARDELEEYLGALIDRKRAEP

GDGLLDELIHRDHPDGPVDREQLVAFAVILLIAGHETTANMISLGTFTLLSHPEQLAA

LRAGGTSTAVVVEELLRFLSIAEGLQRLATEDMEVDGATIRKGEGVVFSTSLINRDAD

VFPRAETLDWDRPARHHLAFGFGVHQCLGQNLARAELDIAMRTLFERLPGLRLAVPAH

EIRHKPGDTIQGLLDLPVAW

 

>CYP105D2    Streptomyces griseus

LLIAGHETTANMISLGTFTLLNHPEQLEALRSGRTTTAAVVEEL

LRFLSIAEGLQRLATEDIEVAGTTIREGEGVFFSTSLINRDTEVYENPETLDWDRPSR

HHLAFGFGVHQCLGQNL

 

>CYP105D2 SGR264 Streptomyces griseus
only one amino acid different to partial sequence CYP105D2 highlighted below
MTESTTEPARQDPAPTAPPTQPTSTTPFPQNRDCPYHPPTGYQPLRADRPLSRVTLFDGRPVWAVTGHALARRLLADPRLSTDRTHPDFPVPAERFANVERRRVALLGVDDPEHNAQRRMLIPSFSVKRIAALRPRIQETVDGLLDAMERQGPPSELVADFALPVPSMVICALLGVPYADHEFFEGCSRRLLQGPGAADVNEARIELEGYLGALIDRKRVEPGEGLLDELIHRDHPGGPVDREDLVSFAVILLVAGHETTANMISLGTFTLLNHPEQLEALRSGRTTTAAVVEELLRFLSIAEGLQRLATEDIEVAGTTIREGEGVFFSTSLINRDTEVYENPETLDWDRPSRHHLAFGFGVHQCLGQNLARTELDIALRTLFERLPGLRLAVPAHEIRHKPGDTIQGLLHLPVAW
 

>CYP105D3    Streptomyces sclerotialus

LLIAGHETTANMISLGTYTLLRHPDRLAELRADPGLAPAAVEEL

LRMLSIADGMLRVATEDIEAGGTVIRAGDGVIFGTSVINRDETVYTDPDALDWHRPAR

HHVAFGFGIHQCLGQNL

 

>CYP105D4    Streptomyces lividans

MTDTDTTTNTHPAAPVAFPQDRTCPYHPPAAYDPLRTARPLARI

TLFDGRPAWLVTGHAAARRLLADQRLSTDRTRDGFPATSARLAAVRERRTALLGVDDP

EHRAQRRMVLPEFTLKRAGALRPSIRRIVGERLDAMIAQGPPADLVTAFALPVPSMVI

CALLGVPYADHEFFEEQSRRLLRGPLPADTRDARDRLEAYLGELIDRKRRAPGEGLLD

DLVRRQASEGATDREQLIAFAVILLVAGHETTANMISLGTYTLLTNPGRLAELRADPA

LLPGAVEELMRVLSIADGLLRMATEDIDVDGQTIRAGDGVVFSTSVINRDESVYPEPD

ALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALESLFDRLPTLRLAAPADEIPFKP

GDTIQGMLELPVAW

 

>CYP105D5    Streptomyces coelicolor

3343 MTDTDTTTNTDTTTNT

3295 HPAAPVAFPQDRTCPYHPPAAYDPLRAARPLARITLFDGRPAWLVTGHAAARRLLADQRL 3116

3115 STDRTRDGFPATSARLAAVRERRTALLGVDDPEHRAQRRMVLPEFTLKRAGALRPSIRRI 2936

2935 VGERLDAMIAQGPPADLVTAFALPVPSMVICALLGVPYADHEFFEEQSRRLLRGPLPADT 2756

2755 RDARDRLEAYLGELIDRKRRAPGEGLLDDLVRRQASEGATDREQLIAFAVILLVAGHETT 2576

2575 ANMISLGTYTLLTNPGRLAELRADPALLPGAVEELMRVLSIADGLLRMATEDIDVDGQTI 2396

2395 RAGDGVVFSTSVINRDESVYPEPDALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALE 2216

2215 SLFDRLPTLRLAAPADEIPFKPGDTIQGMLELPVAW* 2105

 

>CYP105D6   Streptomyces avermitilis

MNAALPMFERHDMTETEIRLTGSPAPSFPQDRTCPYQPPKAYEE

RRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGL

AFPLIGVDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADLVSA

FALPVPSVAICELLGVPYGDHDFFEECSRNFVGAATSAEADAAFGELYTYLHGLVGRK

QAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE

QIDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMN

RDAKAYENPDIFDARRNARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA

VPLDEVPIKAGHDAQGPIELPVVW

 

>CYP105D7   Streptomyces avermitilis

MEIGKSKSSPARSFMTEPGTSVSAPVAFPQDRTCPYDPPTAYDP

LREGRPLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTR

RVALLGVDDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSA

FALPLPSMVICALLGVPYADHDFFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDRK

RKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPE

QLAELRAEPGLMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVIN

RDAAGFAEPDALDWHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLA

APADEIPFKPGDTIQGMLELPVTW

 

>CYP105D8    Streptomyces tubercidicus strain I-1529

VTEAISYFQDRTCPYHPPAGYQPLRETGPLTHVALYDGRKVWAVTGHSEARALLSDQRLSSDRQNPAFPMPFERFA

SIAQVRTPLIGVDDPEHNTQRRMLIPSFSVKRVAALRPDIHRIVDELLDRMLAEGPPAELVSTFALPVPSMVICSL

LGVPYSDHEFFEGESRRLLRSRTAEEAKQARIKLEEYFTDLIAHKEKNPGDGLLDELIEERLRTGTLAHEDLVRLV

MILLVAGHETTANMISLGTFTLLEHPEQLAQLKAEESLMPTAVEELLRFLSIADGMLRVAKEDIEIGGQLIRADDG

VLFPTSLINRDEATYPSPDELDLDRSARHHIAFGFGIHQCLGQNLARAEMEIALRSLFTRIPGLRLAVPAAEIPFK

PGDTLQGMIELPLAW

 

>CYP105D9   Streptomyces sp. JP95

MTDTLDEPQTLADGAEDAPAYPVKRTCPYRMPPGYEELREKGPI

SRVTLWNGRTAWLVTGNDLGRRLFPDARLSSDVLDPRFPLLAPRIEAQRQQAAAPPLV

GVDDPVHARQRRMVLPSFGIRQINALRPEIQKYADDLLDTMLAKGPGVTVDLLTEYAL

PMPSAVICMLLGVPYEDHHYFDERSRHVLSSSGEEQAAQAQQAFTEILAYLDDLIVRK

QAEPGDTLLDELIARQLEEGKVDRQELAMIATVLLVSGHETTSNMIALSTMALLADPD

QLAALRADESLMPRAVDELMRFSSIGDMLMRVAKEDIEIEGHLIRAGDGVILSTMLMN

RDPGAFERPDELDIRRPAGRHVAFGYGIHQCIGQNLARAEMEIALATLFRRVPTLKLA

VPAEQVPVNAPFVLQGVSELPVTW

 

>CYP105E1    Rhodococcus fascians

MAGTADLPLEMRRNGLNPTEELAQVRDRDGVIPVGELYGAPAFL

VCRYEDVRRIFADSNRFSNAHTPMFAIPSGGDVIEDELAAMRAGNLIGLDPPDHTRLR

HILAAEFSVHRLSRLQPRIAEIVDSALDGLEQAGQPADLMDRYALPVSLLVLCELLGV

PYADRDELRDRTARLLDLSASAEQRAVAQREDRRYMATLVTRAQEQPGDDLLGILARK

IGDNLSTDELISIISLIMLGGHETTASMIGLSVLALLHHPEQAAMMIEDPNCVNSGIE

ELLRWLSVAHSQPPRMAVTEVQIAGVTIPAGSFVIPSLLAANRDSNLTDRPDDLDITR

GVAGHLAFGHGVHFCLGHSLARMTLRTAVPAVLRRFPDLALSPSHDVRLRSASIVLGL

EELQLTW

 

>CYP105F1    Streptomyces lavendulae

MSDTEQHAPTLPRQRTCPFSPPPELEELRRTDPISRMRFADDSP

GWLLTRHADVRAALADPGVSSHPGKAPQPWRNLAPEMRAEHYLPGFLIFMDPPDHTRY

RRLLTKWFTMRAIRKLEPRIEQIVTETLDAMEAQGGTVDLVQSFALPIPLLVICELMG

IRYEEREEFMDMVLRLQALDATPEELGALGARMNEFMMKLAAAKRANPGDDLLSHLAH

DPDADPALTDLEIAGIGVLMLIAGHETSANMLGVGTYTLLENADQWALLRDDISLIDR

AVEELLRHQTIVQQGLPRGVTRDMEIAGHQVKTGESLLASLPAANRDPAVFPDPDRLD

ITREHNPHLAFGHGIHLCLGMELARVEMRQAWRGLVTRFPGLRMAAAPEDIRWRDDQI

VYGVYNLPVTWDEAK

 

>CYP105F2   Streptomyces peucetius

VSETDQRPPTLPRQRTCPFSPPPELEELRGTDPISRMRFADDSEGWLLTRHADVRAALAS

RSVSSHPGRTPQPWRNLAPEMRAEEYLPGFLIFMDPPNHSRYRRLLTKWFTMRAIRKLEP

RIEQIVSDALDAMEAEGGPVDLVQSFALPIPLLVICELMGIRYDDRVEFMDMVLRLQDLE

ATPEELGALGAKMNQFMIDLCAAKRKNPGDDLLSHLIQDPDAEPALTDLEVAGIGVLMLI

AGHETSANMLGIGTYTLLQNPGQWDLLRNDIGLIDQAVEELLRHQTIVQQGLPRGVTEDM

EIAGHAIKPGETLLASLPAANRDPEVFPDPDRLDITREHNPHLAFGHGIHLCLGMELARV

EMRCAWRGLVKRFPDLRMAARIEDIPWRDDQIVYGVYKLPVTWGDAP*

 

>CYP105G1    Amycolatopsis mediterranei

MTTKVTENAPSTESLRSPLPPEFVRREDPFHVPPALVAVSERGP

VARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPRFKELSPEFAFPAPSLMIC

ELLGVRYEDRAEFQQRASALLQMNAPVAEAVKNADALRAFMQALVTDKRANPAGDIIS

GLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPS

RIADAVEGLLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP

DLDLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVPLRN

DMLTYGVHSLPIAWDAP

 

>CYP105H1    Streptomyces noursei ATCC 11455 nyst

MSTEADARTAAPQCPVAFPLRRPGRPFPPPEYATYRGGAGLVRS

ELPSGPVWLVTRHEDVRAVLTDPRISADPSKPGFPKAGRTGGAPSQYEVPGWFVAMDP

PEHGRFRKTLIPEFTVRKVRELRPVIQQIVDERIDAMLAAGTSADLVESFALPVPSLV

ISSLLGVPKVDRDFFEDRTRVLVRLSSTDEERDKATQALLRYLGRLIQIKQRRPGDDL

ISRLIAAGTLSRQELSGVAMLLLIAGHETTANNIGLGVVQLLTNPRWIGDDRIVEELL

RYYSVADLVAFRVAVEDVEIGGQLIRAGEGIVPLIAAANHDATAFAAPSEFDPERSAR

SHVAFGYGVHQCLGQNLVREEMDIAYRTLFARIPSLTLAVPVEELPLKYDGVLFGLHE

LPVTWK

 

>CYP105H2    Streptomyces albus

LLIAGHETTANNIGLGVVTLLSHPQWAGDERAVEELLRLHSVAD

MVALRVAVDDVEIAGQVIRKGEGIVPLLAAANHDTEVFGCPHAFDPERSERRHVAFGY

GVHQCLGQNL

 

>CYP105H3   Streptomyces natalensis

MTYTDPAAPETDPPAVDFPQRKPGVPFPPPDYADYRDRKGLVLS

QLSDGKRVWLVTRHEDVRAVLTSPSISSNPEHKGFPNVGNLGVPKQDQIPGWFVGMDS

PEHDRFRKALIPEFTVRRVRAMKPAIERTVDAQLDAMLAAGNTADLVADFALPIPSLV

ISALLGVPPADREFFESRTRVLVSLRSSTDDDRMAAAKDLLRYINRLVEIKQKWGGDD

LITRLLATGAIAPHEMSGVLMLLLIAGHETTANNIALGVVTLLANPQWIGDDRAVEET

LRFHSVADLVSLRVAVQDVEIAGQLIKAGEGIVPLVAAANHDENAFECPHAFDPSRSA

RHHVAFGYGVHQCLGQNLVRIEMEVAYRKLFERIPNLELAVPTDGLDIKYDGVLYGLN

ELPVRW

 

>CYP105H4   Streptomyces nodosus

MTAETEMTTFAPGCPVAFPLRRPGRPFPPPEYADYRAGEGLVRS

ELPASGPVWLVTRHEDVRTVLTDPRISADPSRPGFPRARRTGGAPSQSEIPGWFVALD

PPEHDRFRKTLIPEFTVRKVRELRPAIQQIVDERIDALLAAGNSADLIADFALSVPSL

VISDLLGVPKADRDFFEAKTKVLVTLSSTDEQRDEASKALLRYLNRLIQIKGRRPGED

LISRLLQAGTMNRQELSGVSMLLLIAGHETTANNIGLGVVQLLTNPQWIGDDRIVEEM

LRYYSVADLVSFRVAVEDVEIGGQLIKAGEGIVPLIAAANHDGSVFDKPEEFNPERSA

RSHVAFGYGVHQCLGQNLVRVEMEIAYRTLFERIPTLELAVPVEELPLKYDGVLFGLH

ELPVTWS

 

>CYP105H5   Streptomyces griseus

MTTSPGPTVVDFPRRTPREPLPLSQYAEHRKQNGLVQTHLPNGR

PIWLVTRHEDVRAVLTHPRISANPDNEGFPNVGETMGVPKQEQIPGWFVGLDSPEHDR

FRKVLIPEFTVRRVRELRPAIERTVDERIDAMLAGGNTADLVNDFALPVPSLVISALL

GVPSADRDFFESRTRTLVAIRTSTDEERAEATRQLLRYINRLIVIKKKWRGEDLISRL

LSTGKLSDEELSGVLLLLLIAGHETTANNIGLGVVTLLSHREWIGDDRLVEELLRLHS

VADMVALRVAVDDVEIAGQTIRKGEGIVPLLASANHDTEAFGCPHAFNPERTERRHVA

FGYGVHQCLGQNLVRVEMEIAYRKLFERIPELRLAVPEDQLAYKYDGILFGLHELPVR

W

 

>CYP105H6 SBI_4165 Streptomyces bingchengensis

67% to CYP105H4 Streptomyces nodosus 

VGSVKMATADAIPIEFPRRQPGRLTPPAEYAGLRSQEGLVKSSLPGGSTV

WLVPRHEDVRSVLTDPRISSNPLHEGFPSMGKNGTVPPPDQVPGWFVAYD

PPEHGRFRKALIPEFTVRRIKEMQPAIQRIVDRLIDALLDGGNSADLVAQ

FALPVPSLVICELLGVPYSDHEYFESRTRVLVTFTSTDEQRESAAKELIT

YLTKLISIKHKFPGNDLISGLLKNETLTAQEVSGIALLLLIAGHETTANN

IALGVVMLLLNREWIGDPRAVEEALRYLSVADRVALRVAVEDVEIGGQLI

KAGEGIVPLGAAANHDENAFERADQFDPGRPARHHVAFGYGVHQCLGQHL

VRAEMGTAYRTLFERIPTLRLAVPPEELPFKDEGILFGLHELPVTW

 

>CYP105J1   Amycolatopsis mediterranei rifamycin

MTETVAFPQDRTCPYQPAPGYEPLADRRPIAEVTLYDGRKAWAV

TGHELARKLLCDPRISSDRTNPAWPMVSAAAAVEFTDVQQKVIKLLTALVGVDGPAHR

ARRKLVQAGFTVKRIDSLRPKIQALVDRQIDEMIAEGAPVDLLKKFASPVPLIALCDL

LGIPHEDQDYFEKKAHQILFGPDAGGAYDELMAYLTKLIDKAEQNPGEEGFLQALLAE

RDPSSDVDHEEILQMFLIVLVTGHDTTSSSIGLGAFTLLQHPERLAELRADPSLMPAA

VDELTRFVVVPDGLQRVAADDIEVDADTTIRKGDGVFFLFSLINRDEEAYEDGDRLDW

HRPTFRDHLTYGFGTHQCAGMNHARAIMEIAFRRLIDRLPGLRLAVPADEVRVKPGDA

FQGLAELPVTW

 

>CYP105K1   Streptomyces tendae strain Tue901

MTETFGHDIPSFPMARECPMHPPAEYRKLRVQEPVSRVRMPDGQ

VAWLVLKHDLARKLLADPRVSADRLHPAFPGRLTAEQRTATERVRRLSTRRSMIHLDG

DEHGAHRKILTGEFSLRRIAALRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV

ICELLGVPHEQRRDFHEWAGMLVSRSVSIRERAAASDALNDFLEDLVTEKERGEPTDD

LIGRLIARNRRTPVMTHDEIVGTAVMLLIAGHQTTANMISLGVVALLENPEHKARIAA

DPSLLPPAIEEMLRYFSVVENAPARVATEDIEIGGVTIRKDEGIVVSGLAADWDDEVF

EHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL

PYKDDAGIYGIYRVPVNC

 

>CYP105K2   Streptomyces ansochromogenes

MTEAFDHDIPSFPMARECPMHPPAEYRELRGQEPVSRVRMPDGQ

VAWLVLKHALARKLLADPRVSADRLHPAFPGRLTAEQRAATERVRRLTTRRSMIHLDG

DEHGAHRRILTGEFSLRRIAAQRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV

ICELLGVPHEQRRDFHEWAGMLVSRSVSIQERAAASDALNDFLEALVTEKERGEPADD

LIGRLIARNRQTPVMTHDEIVGTAVMLLVAGHQTTANMISLGVVALLENPEHKARIAA

DSSLLPPAIEEMLRYFSVVENAPARVATEDIAIGGVTIRKNEGIVVSGLAADWDDEVF

GHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL

PYKDDAGIYGIYRVPVNC

 

>CYP105L1    Streptomyces fradiae

MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFS

PPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDG

EAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRDVRPSVEQIVTGLLDDLTARGDEAD

LLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRL

ISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL

QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLL

AAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA

LRPTTDVAGLRLKSDSAVFGVYELPVAW

 

>CYP105L2   Micromonospora griseorubida

MDRTCAWALPEQYAEFRQRATGWPAKVWDGSPTWLVSRYEHVRA

LLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMR

PEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELAS

RPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVL

LLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA

TADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLG

QNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW

 

>CYP105M1    Streptomyces clavuligerus clavulanic

MNEAAPQSDQVAPAYPMHRVCPVDPPPQLAGLRSQKAASRVTLW

DGSQVWLVTSHAGARAVLGDRRFTAVTSAPGFPMLTRTSQLVRANPESASFIRMDDPQ

HSRLRSMLTRDFLARRAEALRPAVRELLDEILGGLVKGERPVDLVAGLTIPVPSRVIT

LLFGAGDDRREFIEDRSAVLIDRGYTPEQVAKARDELDGYLRELVEERIENPGTDLIS

RLVIDQVRPGHLRVEEMVPMCRLLLVAGHGTTTSQASLSLLSLLTDPELAGRLTEDPA

LLPKAVEELLRFHSIVQNGLARAAVEDVQLDDVLIRAGEGVVLSLSAGNRDETVFPDP

DRVDVDRDARRHLAFGHGMHQCLGQWLARVELEEILAAVLRWMPGARLAVPFEELDFR

HEVSSYGLGALPVTW

 

>CYP105N1    Streptomyces coelicolor

MTPPESPTASHTPGATPPRDFPIQRGCPFAAPAEYAALRTDDPV

ARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT

DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVST

SVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRD

DLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELR

KDPDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQ

FDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQ

VVVKHDSATFGLEELMVTW

 

>CYP105N2    Streptomyces glaucescens cytochrome P450

LLIAGHETTTSMIALSTLLLLDRPELPAELRNDPDLMPAAVDEL

LRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD

NHHVAFGYGMHQCLGQNL

 

>CYP107N3 SP0881 91% to 107N1 AJ605544.1

VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW

LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT

PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT

WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE

LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV

DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP

HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*

 

>CYP105P1   Streptomyces avermitilis

MPEPTADAPTVPKARSCPFLPPDGIADIRAAAPVTRATFTSGHE

AWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLL

AKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTFANAVPSMVISDLFGVPVE

RRAEFQDIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDP

DGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDPSLVGNAVEE

LLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRR

PAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGV

HELPVTW

 

>CYP105P2   Streptomyces peucetius

MSQPTAGAPAAPKARSCPFLPPDGIADIRAAAPVTRATFTSGHEAWLVTGYEQVRAVLRD

PSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKLLAKEFTVRRMQALRPNIQR

IVDEHLDAIEARGGPVDLVKTFANPVPSMVISDLFGVPAERRAEFQEIAEAMMRVDQDAA

ATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHD

TTACMIGLGTALLLDRPDQLALLQKDPSLIGNAVEELLRYLTIGQFGAERVATQDGEIGG

VRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAPHLAFGFGAHQCIGQQLARIELQI

VFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELPVTW

 

>CYP105Q1   Streptomyces avermitilis

MADALAGRAPDATPPVAAYPMPRAVSCPLAPPPALQPLRDEQPI

TKVRIWNGSTPWLITRHADQRALLTDPRVSNDDRDPGFPYVNAHRAEIAHATPRLITN

TDAPEHTRLRRTVNAPFLIKRIEAMRPAVQRIVDGLIDDMLDGPNPADLLTALALPVP

SLVIAQLLGVPYADHEFFQRNSNLVLDNSVPAEEARAASGALAAYLDTLLAEKTAAPD

ADVLSEMGGRIKAGEMTHREAVHMGVAMLIAGHETTATMISLGTLALLEHPEQLAVLR

DAEDPKVIAAAVEELLRYLTIVHSGIRRVAKEDIEIGDRVIGAGDGLLFDLHAANWDS

EAFPEADRLDLSRPARHHQAFGYGPHQCLGQSLARLELQVVYGTLYRRFPTLRLAAPI

DRLAFHHTGTTYGVRCLPVTW

 

>CYP105Q2   Streptomyces sp.

LIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHSGLRRVA 182

183 KGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGFGTHQC 350

 

>CYP105Q3   Streptomyces sp.

MADTLTDAAPDTDGRVPEYPMPRATGCPLAPSPAAAELRGDRPITRVRIWNGSTPWLITR 318

 319 HADQRTLLTDPRVSNDDHEPDFPHVNAHRAAIAPHTPKLITNTDAPEHTRLRRSVNAPFL 498

 499 VKRIEAMRPAVQKIVDDLIDDMLAGPSPADLLTALALPVPSLVIAELLGVPYEDHHFFQE 678

 679 NSNRVLDNSLTAEEAQESSRALGGYLDTLFRTKLEQPGEDVLSEMGSKVKAGEMTHQEAV 858

 859 SMGVAMLIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHS 1038

1039 GLRRVAKGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGYGPH 1218

1219 QCLGQNLARLELQVVYGTLYRRVLTLRPAVPVDQLAFNHTGTTYGVKCLPVTW 1377

 

>CYP105Q4   Mycobacterium marinum MM4762

MSDTLASPSP ETASGIPDYP MSRSAGCPFA PPPGVMALAA AKPLTRVRIW DGSTPWLITG

YEQVRELFSD SRVSVDDRLP GFPHWNAGML STVHKRPRSV FTADGEEHTR FRRMLSKPFT

FKRVEALRPT IQQITDEHID AMLAGPQPAD LVAKLALPVP SLVISQLLGV PYEDAEMFQH

HANVGLARYA TGADTVKGAM SLHKYLAELV EAKMANPAED AVSDLAERVK AGELSVKEAA

QLGTGLLIAG HETTANMIGL GVLALLVNPD QAGILRDAQD PKIVANAVEE LLRYLSIIQN

GQRRVAHEDI HIGGETIRAG EGIIIDLAPA NWDAHAFTEP DRLYLHRAGA ERNVAFGYGR

HQCVGQQLAR AELQIVYRTL LQRIPTLTLA TALEDVPFKD DRLAYGVYEL PVTW*

 

>CYP105Q4   Mycobacterium ulcerans

VSDTLASPSPETAAGIPDYPMSRSAGCPFAPPPGVMSLAAAKPLTRVRIWDGSAPWLITG

YEQVRELFSGSRVSVDDRVPGFPHWNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFT

FKRVEALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQH

HANVGLARYATGADTVKGAMSLHKYLAELVEAKMANPAEDAVSDLAERVKAGELSVKEAA

QLGTGLLIAGHETTANMIGLGVLALLVNPDQAGILRDAHDPKIVANAVEELLRYLSIIQN

GQRRVAHEDIHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGR

HQCVGQQLARTELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYGVYELPVTW

 

>CYP105Q5   Streptomyces scabies SCAB11341

MAGTPTDAAS GTDGQLPEYP MPRAAACPLA PPPAAAGLRG EHPISRVRIW NGSTPWLITR

HADQRTLLTD PRVSNDDHEP DFPHVNAHRA AIAPHTPKLI TNTDAPEHTR LRRSVNAPFL

VKRIEAMRPA AQKIVDDLID EMLAGPNPAD LLTALALPVP SLVIAELLGV PYEDHRFFQE

NSNRVLDNSL TAEEAQESSR ALGGYLDTLF RTKLEQPGDD VLSEMGAKVR AGEMTHQEAV

SMGVAMLIAG HETTATMISL GTLALFEHPD QLAVLRDTEE PRVVAGAVDE LLRYLSIVHS

GLRRVAKDDI EIDGRVIRKG DGLLFDLQTA NWDPNAFPEA ERLDLGRPAR QHNAFGHGPH

QCLGQNLARL ELQVVYGTLY RRVPTLRPAV PVDRLAFHHT GTTYGVTCLP VAW

 

>CYP105Q6   Mycobacterium vanbaalenii PYR-1

MTETLAQEAVSVPEYPMERTAGCPFAPPQQMLEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVS VDDRREGFPHWNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVIQQVTDECIDEILA GPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLHQYLINLVEEKQ AHPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLENPEQAALLRDSDDPKFI ANAVEELMRYLSIIQNGQRRVATEDIEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRDATQQLG FGYGRHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYGVYELPVTW

 

>CYP105Q7   Mycobacterium smegmatis

MSETLTQPSATDIPGYPMERAAACPFAPPPQMLDMNKAKGLSRVRIWDGS

TPWLITGHEEARALFADSRVSVDDRRPGFPHWNEHMLATVHKRPRSVFTS

DAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDECIDAILAGPQPADIVD

KLALPVPTVVISEMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLH

QYLIDLIEKKQAEPAEDAVSDLAERVTAGELSVKEAAQLGTGLLIAGHET

TANMIGIGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQR

RVAVEDIEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRDAGQQL

GFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLA

YGVYELPVAW

 

>CYP105R1   Streptomyces avermitilis

MTQTAAVTTAWPLHRTCPMSQPPALAAFRDGPPRQVLLRGDQPA

WLITRYADVRQALADPRLSVNDQHPNWPNRLLFPVPPRAVSFWRMDPPEHGAYRKMVA

AEFIAHRTQALRPLLQSITDELLDEMAAMPKPVDFHSVFALPLPCIAIARIFGVPDED

MSEFKENTSALLNQKEPEKAVQAFLATTAYLDGLARAKEREPKDDLLSRLVVNFVRPG

QLSHDDLVAMVRLMLVAGHETTANQIALSIFTLLDRPGVLAELRADPRLLTPVVDELL

RYWSIAQDNVVRTATEDLSVGDARIAAGDAVVISVPGANHDEAVFPDAADFDIHRDNS

RHLAFGHGPHFCPGGPLARTELEIAITSVFRRFPDLRLAIGRDQVPVHTDTLVYGLEC

LPVTW

 

>CYP105S1   Mycobacterium smegmatis

MTQAQALPPLHIRRDAFDPTPELGEIRAGEGVHVTVNPFGMQVYLVTRHE

DVKTVLSDHERFSNSRPPGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQ

RLRRMLTPEFTIRRIKRLEPRIVEIVDAHLDAMESAGPPADIVADFALPI

PSLVICELLGVPYEDRTDFQQRSARQLDLSAPMPERLELQRQGRAYMRGL

VERSRTRPGDDILGMLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGL

GVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTTDVEL

AGVTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRRGAPGHLAFGHGVHHC

LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQSLAVAW

 

>CYP105S2   Mycobacterium vanbaalenii PYR-1

MSQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPP GFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARD GEASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGAR TNPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPA VEELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGH GVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW

 

>CYP105S3 Frankia alni ACN14a

MRRAQFDPISELSTARDTVGVCPVVTPFGVPAHLVSRYDDVREVLSDSVRFSTADRHALMPPDAAGPTEQ

EYAQARVGNLLAYDPPEHTRLRRMLTPEFTMRRMRALEPRIVDIVSAALDDVERAGRPADLVSTFALPVP

SLVICELLGVPYADRAEFQRRTVDQLDASHPPEHRLALQQASRAYMATLVERARRDPGEDILGMLVREHG

DDISAEELVGIASLLLLAGHETTANMLGLGTLALLRHPDQLARVRDDPASVEPAVEELLRWLSIVHAGIP

RTATTEVTIAGSTIAAGEHVVLALPGANRDPALVDDPDRLDITREPAGHVAFGHGLHHCLGAPLARLELR

IAYPALLRRFPGLALAVPYEQIAFRPYSVIHGLQALPVTW

 

>CYP105S4 Frankia sp. CcI3

MAAAPIVPLHIRRAQFDPIEELVRIRDTDGVCRVVTVFGIPAYLVSRYEDVREILADPGRFSNVNQWVVG

PGGPVLSDEEIAELRAGQMLAFDPPDHTRLRRMLTPEFTVRRMRGLEPRIRDIVDAALDEVERAGRPADL

VATFALPVPSLVICELLGVPYSDRAEFQQRTRRQIDASLPIEQRLALQREARAYMAGLVTRAQAAPGEDL

LGMLVREHGDELSTAELVGIASLLLVAGHETTSNMLALGTLALLRHPDQLAMVRDDPAQVEPAVEELLRW

LSIVPSGVPRTTTTEVEIAGHRIPAGEQLLLALPAANRDPALVGDPDRLDITRGAPGHVAFGHGVHHCLG

APLARMEMRIAFPALLRRFPDLALAVPYEQVAFRAHHVVHGLHALPVTW

 

>CYP105T1    Burkholderia fungorum

MRKTMTSAINDVRPQTTSTFPFARTGSPLHPPAEYARYRDGQPV

TRVQMWDGRYAWIFTRMEDVKAVLSSPHFSVVPSKPGYPFLTPARAATVKSYQTFITM

DPPDHTRFRRMLTRDFTQKRMEELRPQIAAYVNRLIDEMLARGSPGDLVSALALKLPV

TVVSMLVGVPYEDHEDLVKWSGQRLDLEQNPTVSESAADNMLAYFDGLLQRKERDPGD

GADMLSRLVIEQIKPGHLSRLEAIHMVNLLYFAGHETTANQIALGTLSFLLDPRQRAL

LENNPGLLKNAIEEMLRFHTISHYNSCRVATADVEVGGTLIREGEGAYALIMAANRDP

AAFPAPDRFDIERPNSQEHVAFSYGLHMCLGQPLARLELQVCFEALFRRLPRLRLAVP

LEELPFKREMYVYGLHALPVTW

 

>CYP105U1   Streptomyces hygroscopicus strain NRRL 3602

MDEIRDYPESRAAACPFSPPLGYEELRERSAVTRVRMWDGSTPF

LVTGYHEARAALGDSRFSADGTHKAMPRFVKFEVPAEVFNLGRMDDPEHARIRRMLTA

NFTIRRTEAMRPMIQGIVDGLLDRLIAQGPPADLVADFAFPLPSQVIGVMLGVSDADF

AEFQQASQGVMDFTASAEEMGAALGVMVDYVARMCAAKRADPGDDLLSRLIVDQELTG

GLTQQQVVATALVLLLAGHETTANMIALSTVLLLSHPEQLARLRADAGLMGNAVDELL

RYITIVQEGTGRVATEDVEVGGVLIPGGEGVIINLPSANRDPHFADAHELDLSRPNAR

EHVAFGFGVHQCLGQTLARVELQIALETLLRRLPTLRLEVPFDDLAFLYESMNFGVAR

VPVAW

 

>CYP105V1   Streptomyces sp. HK803

MSQLSSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDG

KEVWLITGYDEIRSIFTDPRISVDNTQPGYPWLSEQARTVVLTGGVKPVGRMDPPEHT

AMRRMLGQGFLVKKIQNMRGDVEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWV

LGVPPADKRLISLVPRLFDEDSGLEGAMEARAELFAYIDELITHRENQPGDDIISHLV

GYYQKGELSRVSVLTQSVTLIAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPA

AVEELLRYTVVTEFSSKRVAAADIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLD

VRRDAKQHLGFGAGIHTCIGKQLARMELEVVYGTLFRRIPELRLAVPFDQLVFRNTFD

VQGVRALPVTW

 

>CYP105W1   Micromonospora echinospora

MPRRCPFGPPAEYARLRTERPVARLPMLGGNTAWVVSRYADVKR

VLSDPRMSADRRRAGFPRFAPTTESQRQASFANFRPPLNWMDPPEHTAARRQIVDEFA

ARRVRQLRPLVERVVDEHLDAMTAGRSSADLVPSFSYPVPSRVICEMLGVPYGEHAFF

ERRSTRMLSRGVPADERARCAREIREFLDGVVTDKERHPGDDVLSRLLAAQRAAGEPD

HEAVVSMAFVLLVAGHVTTSNMISLSVLALLTHPERLARLRAEPDRFPAAVEELLRYF

TIVEAATARTATADVTVGGVTIRAGEGVVALGQAANRDPAAFDRPDEFDPDRDARHHL

AFGYGRHICPGQHLARLELDVALSRLVRRLPGLRLTVDVDDLPLKEDGNIFGLHALPVAW

 

>CYP105X1   Pseudonocardia autotrophica same as Amycolata

MAEDTLGQDFPMQRQCPFEPPKEYERLRAEQPISRVRMPDGTPA

WLVTLHEDVRTVLASPAFSSDLAHPGMPAVNPEIRTIARQQRPPFSRMDPPEHSFFRR

MLIPEFTVKRTKTLRAGIQSVVDGLIDDLLRKSPPVDLVDEFALPVPSLVICQLLGVP

YSRHEFFQQQARVILSRQSTREQVGAAFTALRAYLDTLVEEKLHTPGDDLTSRLATEH

LEPTGDVRRQDLVASCMLLLTAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEA

VEELVRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDI

HRGNRRHACFGYGVHQCIGQHLARTELEVAFSTLFTRIPTLQIAAPSDELDYDHDGML

FGLHELPVTW

 

>CYP105X2   Amycolata autotrophica same as Pseudonocardia

LLIAGHETTSHMISLGVTALLERPDQLAALQNDLTLLPEAVEEL

LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN

RRHVAFGYGVHQCLGQNL

 

>CYP105X3   Micromonospora inyoensis

LLIAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEAVEEL

LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN

RRHVAFGYGVHQCLGQNL

 

>CYP105Z1    Streptomyces scabies SCAB17851

MTTHPPHPPL PTLRPLLDPS PEYAKWRTEE PIRRVTIWGD NSPWLITRHE DARVVLADPR

FSADATRDGF PGFRPQSPPR GPGQFFMMDP PDHTRLRRVL IPDFTFRRIE QLRPAIARIC

GELLDAMTAD DATAADLVEA YALPLPSLAI CELLGVPYED HDFFQRQANA FSSFSSGPEE

MMAARTALHT YLGDLLARRG REPADDLLTR LARDRVATGE ISAPEAVGIA SLLLVAGHET

TANMFPLAVL DLLRHPAQLA ALRADPALWP GAVEELLRHL TVTHAGLRRI ATEDVVVSGV

RIRAGEGVIV ALQAANRDPS AFTAPDTLDV RRTTTGHLAF GHGLHQCIGQ SLARAELQVG

LPALFDRLPG LRTAGEPEDF TPAISAVHGV RSLPVSW

 

>CYP105AA1   Streptomyces tubercidicus strain R-922

MTGRSACGSGARSAPSVRTPASPPVGPSAAPVTPVTPSQPLTLL

EKDCPMTAMQPTARTQPMERTCPFSPPEGYRTLREEDPITQVTFPDGAKGWLVSRYSD

VRAVLADPRFGANGQQPPLPGMFLTMDPPEHTRFRRLLTGQFTVRRMRKLAPAVEQIV

AERLAEMAAAEGPVDLVQAFALPVPSLVICELLGVPYADREEFQENSSRMLRLDASQE

QFEQAQMAMYERIHQLVVAKRAHPTDDILSGLVQSGVLTDEEVTGVGVLLLIAGHETT

ANMIALGTMCLLGHPGQLASLRADPELMDDAVEELLRYLTIVQYGLRRMALEDVELGG

QRIKAGSVVVAALPSGNRDATHFSGDPETLDVRRPYSPHLAFGHGVHQCIGQQLARVE

MKAALSALIDRFPGLRLAVPAREVPMRDDMLIYGVHELPVTW

 

>CYP105AA2   Streptomyces tubercidicus strain I-1529

MTRTVPGPQALPTERDAGPFAPPRDISRMREARPVSPMVFPDGH

EGWIVTGYDAVRRLMADTRFSSRQDIGILHVPYETPGMPAPTEPSPQIPGLFIAMDPP

DHTRLRRKLTGAFTVKRMKQLEEHISDIVERQLDELTRLAPPVDLVKEFALPVPSLVI

CALLGVPYADRETFQVNSAKFLEKDVSLDEKMAAYTGLTTYLSELVTRKRAAPGEDIL

SDLARHDDLTIEELTGMAFLLLLAGHETTANMLALGTFALLEHPEQLAELRADPDLMP

GAVEELLRYLSIADIFYRYATEDIELGGETIGKGSTVVVSLLAANHDPQRFDNPDTLD

IHRTARGHLSFGHGIHQCLGQQLARIEMRAGFEGLLRRFPTLELAIPADEVKLKTDMN

IYGVHELPVTWTDTAR

 

>CYP105AA3 = old CYP105Y1    Rhodococcus sp. RHA1 Rha04313

MSKTVAVPYGLPMERDAGPFDPPRRITRLRETRPVSPMVFPDGHEGWLVTGYDAVRQLMADTRFSSRQDIGILHVPYETPGMPAATEPSPQMPGVFIAMDPPDHTRMRRKLAGAFTVKRMKQLEDHIIDVAERQLDAMARLTPPVDLVKEFALPVPSLVICELLGVPYADRDNFQVNSAKFLIKDQPLDDKMAAYGALSTYLADLVTRKRAAPGDDILSDLARDDDLTIEELTGAAFLLLLAGHETTANMLALGAFALLENPEQLTELRTDPDLLPDAVEELLRYLSVADIFYRYATEDIELGGETIRAGSTVVVSLLAANRDPQRFDNPDTLDIRRKARGHLSLGHGVHLCLGQQLARLEMRAGFEGLLRRFPTLGLAIPAGDVKLRTDMNIYGVHELPVTWTETSR

 

>CYP105AA4   Amycolatopsis azurea              GenPept BAD91667             80% to CYP105AA2  

1 MTETVPVPQG LPMQRDAGPF APPSEITRLR GARPVSPMVF PDGHEGWLVT GYDEVRQMMA  61 DTRFSSRQDL GILHLPYETP GMPAPTEPSP PMPGMFVAMV PPDHGRLRKR LTGAFTVKRM 121 KQLEEHIVEI TEQHLDAMTK LVPPVDLVKE FALPVPSLVI CELLGVPYED RENFQANSAQ 181 LMVRDQTLEE KMAAFIGMNT FLTELVTRKR ETPGDDILSD LGRYDDLTIE ELAGAAFLLL 241 LAGHETTANM LALGTFALLE HPEQLAELRA DAELLPAAVE ELLRYLSVAD IFFRYATEDL 301 ELGGETIRAG STVIVSLLAA NRDPRRFENP DTLDLHRNAR GLLSFGHGVH QCLGQQLSRI 361 EMRAGFEGLL RRFPTLSLAV PADEVKLKTD MNIYGVHELP VTW 

 

>CYP105AA5   Streptomyces lydicus             GenPept BAG50414.1             79% to CYP105AA4  

1 MSRTVPVPQG LPMERDAGPF DPPRDLTRLR EARPVSPLLF PDGHEGWLVT GYEAVRRLMA  61 DTRFSSRQDI GVLHVPYETP GMPVATEPSP QVPGLFIAMD PPDHTRLRRR LTGAFTVKRM 121 KMLEEHIHDI VERQLDAMAR LAPPVDLVKE FALPVPSLVI CEMLGVPYED RETFQVNSAK 181 FLVKDQPLDE KMAAYGALTT YLAELVTRKR ATPGEDILSD LARQDDLTVE ELTGIAFLLL 241 LAGHETTANM LALGTFALLE HPGQLAELRA HPELLPGAVE ELMRYLSVAD IFYRYATEDI 301 ELGGETIGKG STVVVSLLAA NRDPLRFDNP DALDVRRAAR GHLSFGHGVH QCLGQQLARI 361 EMRAGFDGLL RRFPTLELAL PADEVRLRTD MNIYGVHELP VTW 

 

>CYP105AA6   Rhodococcus opacus B4             GenPept BAH51173.1             78% to CYP105AA4  

1 MTVKQTHTVS VPHGLPMERD AGPFDPPGDI TRLRDARPVS PLIFPDGHEG WLVTGYDAVR  61 QLLADTRFSS RSDLGIVHVP YETPGMPAAT EPSPQVPGLF IAMDPPDHTR LRRKLTGAFT 121 VRRMKQLEEH IADIVERQLD EMARLTPPVD LVQEFALPVP SLVICELLGV PYADRDTFQV 181 NTAKFLVKDQ ALDEKMAAYG ALTTYLAELV ALKRVTPGED ILSDLARDDD LTIEELIGIA 241 FLLLLAGHET TANMLALGAF ALLEHPEQLA ELRADPELMP NAVEELMRYL AVADIFYRYA 301 TEDIELGGET IGQGSTVVVS LLAANRDPRH FDNPDTLDLH RKARGHLSFG HGVHLCLGQQ 361 LARLEMRAGF AGLLRRFPAL ELAVPAGEVK LKTDMNIYGV HSLPVCLQPV STY 

 

>CYP105AA7   Actinosynnema mirum DSM 43827             GenPept EEH76286.1             69% to CYP105AA4  

1 MDLTSPIPIP DGLPQERDAG PFAPTTFVAD LRARRPVCPL VFPDGHVGWL VTGHAAVRQV  61 LADTRFSSRL DLGVLHVPHP TPGMPQATEP SPQVPGLFVA MDPPDHTRLR RKLTGAFTVK 121 RMRALEERVA QVVEERLTAM AALTPPVDLV REFALPVPSL VICELLGVPY ADREVFQANT 181 ARFLVKDVEL AEKAAAYGAL TGYLAGLVAS KRAEPGEDVL SDLARHEDLT VEELTGCAFL 241 LLLAGHETTA NMVALGTFAL LEHPDQLAAL RAEPGLLGGA VEELTRYLSV GDLFYRYATE 301 DLELHGELIP AGSTVVLSLL AANHDPEAFE DAGALDVRRD ARGLVAFGHG VHQCLGQQLA 361 RVEMRAGFAG LLRRFPDLAL AVPAGEVPLK TDMNVYGVHA LPVTWGTAAG 

 

>CYP105AB1   Saccharopolyspora erythraea NRRL23338

LRSQEPVKRVRTIGGGTAWLVTRHEDVRRVLSDPRMSSDRTMPGFPSLVPGRRAIVAENK

QAMIGMDGQEHAEARRAVIGEFTVRRINRMRPRIQEIVDECVDRMLAAGGPVDLVRELSL

PVPSLVICELLGVPYSDHDFFQSRSALMISRSTPPERRRDVVLELRRYLDELVAEKVREP

ADDLLGRQVAQQSEKGEVDREGLVSLAFLLLIAGHETTANMISLGTLALLDNPDQLARIT

EDPARTPAAVEELLRYFSIVDGATSRTALADIEIGGVLIREGEGVVAVGLSANRDPEAFD

SPDELDLDRQARNHVAFGFGAHQCLGQNLARVELQIVFDTLFRRIPGLRLADGLDGIRFK

DDALVYGAHEMSVTW

 

>CYP105AB2   Salinispora tropica (marine actinomycete)

MTETASIATTRTASGQLTDAEFPVQRGCPFTTPTEYEQIREESSIAKVRLKNGGEAWWIA

GHELGRSVLADRRFSSDRRRDNFPFVSTDPETRAQLQSQPTSMLGMDGAEHAQTRRALMG

EFTVRRMAGLRPRIQQIVDQHIDEMLATPQRSVDLVEALSLPVPSLVICELLGVPYADHD

FFQGLTGPLLRHTTPPEVRLRIQEELNTYLGTLIDRKLTDPTDDLLSRQIAKHRDNGTFD

RASMVSLAFLLLVAGHETTANMISLGVVGLLQHPDQLVIIKDDPDKTPLAVEELLRYFTI

ADSVTARVATEDVQLGDTTINAGDGVVISGLAADRDPTVFAEPDRLDLERGARHHVAFGF

GPHQCIGQTLARMELRIVFDTLFHRIPTLRLAAPLDDIPFKSDAFVYGIEELPVAW

 

>CYP105AB3   Nonomuraea recticatena  AB180844 Gene name moxA

64% to CYP105AB2 Salinispora tropica (marine actinomycete) 

MTKNVADELAGLELPVERGCPFAPPAAYERLRERAPINKVRLTS GGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAE HSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVI CELLGVPYTDHDFFQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFS RQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPG RTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDP AVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFK GDSVIYGVHELPVTW

 

>CYP105AC1   Saccharopolyspora erythraea NRRL23338

MQKHAPHNADDVLESLPRDRPSGCPFDPPEGLAEIRGQRPLTRLVYGDGHVGWLATGHAV

VRAVLADRRFSSRYELMHFPVAMPGLPAQIPPAQVGDITGIDPPEHTRYRKLLTGKFTVR

RMRALTERVEQITAERLDAMQRLGPPVDLVEAYAQPIPALMICELLGVPYDRLEEFLGLV

AASGDRDLTPEEQFDAFAKIQEFVRELVPAKRAKPTDDLLSDLTTTELTDQELAGIGGLL

LAAGLDTTANILALGTFALLRNPEQIAALREGDADRAVEELLRYLSIAHTGMRSALEDVE

IDGTLIRAGETVTLSIQAANRDPRRFTDPDALDLRRHAAGHLSFGHGIHQCLGQQLARVE

MRVAFPALFNRFPGLRLAVAPEEVPLRGDMNIYGVHGLPVTWDGA

 

>CYP105AD1 Frankia alni ACN14a

MTQAPQYPQTRTCPYEPPPAYKEIGQEGPVVKVSLFDGRESWMVTGYRESREILTHPNLSSLRTHPNFPI

VAPRFRSPVARSLALLAMDPPIHDVYRRYLNPHFSLRSVRAMRPELERIIAGYVDRIIDHGPPADLIEML

AVPMPSLIICHHLGVPYADHDFFQDCSGKVMLAGEEEAGKAAQDLVEYLDNLVTEQQRNPTDGLIGQLVR

ERVSDGDIGHDELVSIALVLLIAAHETTASTLAIGIINLLGHPEELAKLRADISLLPGAIEELLRYVATT

DLVAVRIAKGDIEIAGHHIREGEPVLVSGTLANRDPQVHQRADEFDIQRDDTFHLTFGFGIHQCLGQNLA

RLEIELALRELITRLPGLRLAVPMEELPILSAGTVQRVLELPVEW

 

>CYP105AE1 Frankia alni ACN14a

MNRVTLFDGATAWLVTGHSHSRRLLADPRVSADRSRPDFPVVLPRFEADVFKPLAIIGFDPPQHGLQRGL

LTADFSMRSVRAKRESIERLVESLADRMLAAGPPADLVLDYSLPIPSMVVADLLGVPYADHQFFEDATVR

LLQATTPQGAEAAGEELLNYLDEQIRLRERDPDDTLLSRLGEHVHDEGLGRDIINKIALALLVGGHDTTS

QMIALGVVTLLDHPDQLAILRSDPSALPGVVEELLRMVSVTDLAGVRVATEDVEIDGQVIARGEGLIFCN

SMANRDPAVYDAPYEFDVRRSADDPPATRRHLTFGHGPHQCIGRNLARMELEIAYRVLFEKIPNLRLAVP

RDELPMRHGSTMQGVHRLPVTW

 

>CYP105AF1 Frankia sp. EAN1pec

MSSNQAVVATPPAFPMDRGCPYHPPAGYAQLQQDGPITRATLFDGREVWVVTGYEEARRLLVDPRLSSDR

SRPDFPVLVPRMAAAKLVALVGMDPPEHDIQRRMLIGSFTVRRANALRPDIERIVGGRVDALLAHEPGEV

VDLVPEFALPIPSTVICELLGVPYGDHEFFEEQTRRMVIATSTAAEAAAASRALVDYFDELIARKRERPG

EGLLDELIAERLVTGQIGQDDLASMAMFLLVAGHETTANMLGLSVLALLEHPDQRARLIEDPAGRAAGAT

EELLRFLSVADEIQRIAAADIEVAGVVIRAGDGVYLPTAAANRTAATFPDPDALDIGRVPRGHLAFGYGI

HQCIGQNLARVELEIGLRELFGRIPTLRLAEPVEALGAKPGGSVQGVYRLPVVW

 

>CYP105AF2 Frankia sp. EAN1pec

MTGTEIPEYPLARTCPFHPPAGYARYREHGPVNPVRLYDGRRVWAVTGHAEAREVLLNTRLFSSERADPR

YPATSPRFEAARKVRNFIGMDPPDHTAQRRMLQSSFTMRRINGLRPGIQRLVDELLDAIVAKGPVVDLVP

EFALPIPSIVISELLGVPYGDHAFFEQQSRRVASGTSTLEESADAFTQLLQYLDGLIQDKERSAGDGLLD

VLIAEQVRPGVLTRRELVDISLLLLVAGHETTASAIALGVVALLEHPDQLAALRADPALLPSAVEELLRF

TTIADSVARFATADTELAGQPVAAGDGVLVVLSAANRDGTVFPDPDLLDLARRARSHVAFGHGAHQCIGH

NIARAELEIAFSTLFARLPGLRLAVPLDRLPGKDAGGVQGVFELPVAW

 

>CYP105AG1 Frankia alni ACN14a

MTTRHLIDQPISRDLAHPLDPPAAYTELRENQPVVRARFPNGSTGWLVTRFEEGSQVFSDPRFSAKRRRH

DTPEGEQAEAGDDAPFDAGFVMMDEPDHGVYRRLLTARFTPKAVQTRLQPYLDRIVAEHLDAIAAGPETF

DFVQALSLPIPCLVICELLGVPYADRDGFHHATEVMMDTGVSRAERDRGAHWLVDYITALVADKRRTGDT

EGILAELIGKADDEGSILSERQLVGLGVLLLFAGHDTTAAMMGLSTLTLLTHPEQRRDLTEHPERIGTAV

EELMRYLTIVQFGLGRVAAQDVELGGAHIGRGELVVVAMNAANRDPRVFADPDALDLDRTMVRHLGFGYG

VHACLGQNVARAELRTVLPALFRRFPHLRLATPPNEVPMDFTGTNYGVRKLMVTR

 

>CYP105AH1 Frankia sp. EAN1pec

MRELPPCAVRIPAGAADSRLAWLVTRYPDARQALMDPRLSADETLPGAPVRIQVPPDQKPGSFLRMDDPE

HARLRGTITTEFTARRVRGLRPAVQRLIDELLDGLAAGPRPTDLQDAFSRTLPTLVIARVLGVPDADSPF

FVEKTRVTISQGDTARSYAAYQEMSEYLGVLATRKQKEPADDLMSRLAVNHLATGKITLDELVGIARLVL

VAGHETTTNQIALNILSMLLDDDLRRTVLADDGVRIPQFVEESMRYWSISQDAIVRLAVEDFELGGTTMH

KGDAVVISIPAGNHDESMFPDPDRIDLDRDSGDHLQWGVGPHYCQGAPLARLEMELALKTLFGRFPGLRL

ATDDPDSVFRTGTVFHGVRELPVTW

 

>CYP105AJ1 Frankia sp. CcI3

MQNAHSDLRMSSRGDLLRSPIPLPMAGERTEPAPGMFTAMDPPEHTRYRRHIVEWFSTRRTRSLEPRVIE

IVDQHLDAMIAGGGPADLVSAFAEPVSALVICELLGVPVEQREVFGAAIAALFTVHSSAEEAISGWQNIG

GLLMGLIQAKRVASADDLLGTLVARGELSDEELMTIGSVLLVAGHDTSTNMIAMGTFALLEHPEQYAALA

ADPGLAPGAVEELLRYLTIVHAGSIRAVSADLEFDGHQLTAGDAVSLSLAAANRDPALCDAPDRLDITRE

PVPHLAFGHGIHQCVGQQLSRLELRIAFESLARRLPNLHVAVPTSEIRTRSEMIIYGVRELPVTW

 

>CYP105AK1 SBI_6930 Streptomyces bingchengensis

47% to CYP105S3
MSNLRSNIITWLGRKYFSRIQKNGFDLSKMSFLPSATLAPLRRNGLDPVD

ELSRTRAKEPISKLPLPFGMKGWLVTGYDETKAVLGRTNGFSSDFTNLAE

KNIGIAAQQNPGGLGFSDPPTHTRLRRLLTPEFTMRRLSRLTPRIHSIVE

ERLDEMAAMGAAGDPVDLVQSFALPIPSLVICELLGVPYEDRADFQQLSM

ARFDLFDGADASFGAISDSLSYLLDIVKKQRESPGDGLLGMLVKEHGDEI

DDQELAGLADGVLTGGFETTASMLALGTLVLLRNPEQFAEIRDNDDVVDR

YVEELLRYLTVVQVAFPRFAKEDMEIAGTKISSGDLVLCSLSGANREEKL

GPDMERFDPHRQTPSHLAFGHGIHRCIGAELAKMELRAAYPALVRRFPEM

RLAVPQEKLAFRKLSIVYGVEALPVTLK

 

>CYP105AL1P  Frankia alni ACN14a             YP_710901.1             CAJ59294.1             42% to CYP105AB1 Saccharopolyspora erythraea MEAPLMTLSVESHLPSCPMERSSPFEPPPGYARARSEAPITKVRLVDGSTGWFVTGHALVRRLLNDPKVS KNGLRPGYPPLVPDQEALVRGQKGFLVWMDPPDHTMYRRMLAGEFSVNTLERLRPHVEHIVNECIDQLLD AGPPADLVQVLSLPVPTMTICELLGVPYTDRQLFQESTAATVNLRTTQEERNRTVAELRQCATRAGDRLP HALPAAPGPARRAADALGADRLRAGRGRTGEDGLVVLLTEDPPEERRQEVIDAAGSCPAQAILVDGE

 

>CYP105 fragment  Streptoalloteichus hindustanus

LLIAGHETTANMLALGAFALLEHPEQLAELRANPDLMPGAVEEL

MRYLSIVHIGPVRTAVADVEIEGQLIRAGESVTVSVPAANWDPAKFPEPERLDLTRRT

SGHLAFGHGVHQCLRQNL

 

>CYP106A1    Bacillus megaterium

MNKEVIPVTEIPKFQSRAEEFFPIQWYKEMLNNSPVYFHEETNT

WNVFQYEHVKQVLSNYDFFSSDGQRTTIFVGDNSKKKSTSPITNLTNLDPPDHRKARS

LLAAAFTPRSLKNWEPRIKQIAADLVEAIQKNSTINIVDDLSSPFPSLVIADLFGVPV

KDRYQFKKWVDILFQPYDQERLEEIEQEKQRAGAEYFQYLYPIVIEKRSNLSDDIISD

LIQAEVDGETFTDEEIVHATMLLLGAGVETTSHAIANMFYSFLYDDKSLYSELRNNRE

LAPKAVEEMLRYRFHISRRDRTVKQDNELLGVKLKKGDVVIAWMSACNMDETMFENPF

SVDIHRPTNKKHLTFGNGPHFCLGAPLARLEMKIILEAFLEAFSHIEPFEDFELEPHL

TASATGQSLTYLPMTVYR

 

>CYP106A2    Bacillus megaterium

MKEVIAVKEITRFKTRTEEFSPYAWCKRMLENDPVSYHEGTDTW

NVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSL

LAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIVASLASPLPIIVMADLMGVPSK

DRLLFKKWVDTLFLPFDREKQEEVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDL

LKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDL

VPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFT

LNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEENLT

DSATGQTLTSLPLKASRM

 

>CYP106B1    Bacillus anthracis str. Ames

1 MASPENVILV HEISKLKTKE ELWNPYEWYQ FMRDNHPVHY DDEQDVWNVF LYDDVNRVLS

 61 DYSLFSSRRE RRQFAIPPLE TRININSTDP PEHRNVRSIV SKAFTPRSLE QWKPRIQSIA

121 NELVKDIENC SEVDIVEQFA APLPVTVISD LLGVPTTDRK KIKAWSDILF MPYSKEKFND

181 LDAEKGIALN EFKAYLLPIV QEKRYHLTDD IISDLIRAEY EGERLTDEEI VTFSLGLLAA

241 GNETTTNLII NSFYCFLVDS PATYKEVREK PKLISKAVEE VLRYRFPVTL ARRITEDTNI

301 FGPLMKKDQM VVAWVSAANL DEKKFSQASK FNIHRIGNEK HLTFGKGPHF CLGAPLARLE

361 AEIALTTFIN AFEKIALSPS FNIEQCILEN EQTLKFLPIR LKPQ

 

>CYP106B2P  Bacillus cereus ATCC 14579

1 MTSVITDGEI VTFSLGLLAA GNETTTNLII NSFYCFLVDS PGIYEELRKE PNLILKAIEE

61 VLRYRFPVTL TRRITALSER ESPSPLGMG

 

>CYP106B3P  Bacillus cereus ATCC 14579

LKEDTNIFGPF

 1 MKKNQMIVAW VSAANLDEKK FSQASQFNVH RTGNEKHLTF GKGPHFCLGA PLARLEAEIA

61 LTTFINAFEK IELFPSFCLE KCILENEQTL KYLPIRLKAT

 

>CYP107A1    Saccharopolyspora erythraea

MTTVPDLESDSFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTG

YDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLR

KLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELLGVD

EKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRV

QDDDDGRLSADELTSIALVLLLAGFEASVSLIGIGTYLLLTHPDQDQLALVRRDPSAL

PNAVEEILRYIAPPETTTRFAAEEVEIRGVAIPQYSTVLVANGAANRDPKQFPDPHRF

DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSL

LLRGIDHLPVRLDG

 

>CYP107A2   Streptomyces rochei plasmid pSLA2-L

MTTDAHTAVPSLDSDLFHIDQYEAYAALREREPVSKVSFIGREA

FLITRHAEAKAALGDLRLSNDFKKQPPGVELPTYHGIPEDVRPYFANNMGSNDPPAHT

RLRRLVSREFTARRVESMRTRVAQLAEHLLDGLAGERETDLVERFAYPLPITVISELL

GVEERYQGDFGRWSNEFLVIDADRVEQREHAARALVGFILELVDRRRADPGSDLLSAL

IHVHDEDEDRLSTDELASVVLILLIAGFETSVSLIAMATYLLLTHPGELAKVRADPSL

VPNAVDEVLRFLGPAEITTRGTLEPVEIGGVHIPAHSTVLIAGAAANRDPRRFPDPER

FDVTRDTGGHLSFGHGIHFCVGGPLARLEGEIALRALLNRFPGLDLAIPAEQVRWRRS

FLRGIESLPVRLGR

 

>CYP107B1    Saccharopolyspora erythraea NRRL23338

MTTGEVPDLLAFDDAFAQDRHNRYARMREEPVQRIRTVNGLDAWLITRYEDVKQALLDPR

IAKDFGRTQQIIEKRLADAERRPGFSPDLGPHMLNTDPPDHTRLRKLVVKAFTARRVEGL

RPRIEQITDDLLDRLAGRSEVDLIDEFAFPLPITVISELMGVEDSRRDDFRSWTNVLVDG

SQPEAQAQASVAMVEYLTELIAKKRTEPGDDLLTALLEAVEDGDRLSEGELIAMVFLLLV

AGHETTVNLIGNCVLSLLGNPDQLAALRNDPSLLPGAIEETLRYESPVANGTFRHTAEAV

RFGDVVIPEGELVWVALGAANRDGERFEDPDRFDITRETTGHVAFGHGIHFCVGAALARL

EAQIAVGRLLERFPDLRMAASPDDLRWRFSVLMRGLEKLPVRPGA

 

>CYP107B2   Streptomyces sp.

LIAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDSPVGIATFRFSTE 182

183 ALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFGFGMHHC 344

 

>CYP107C1    Streptomyces thermotolerans

MTALNLMDPEVLRDPFGAYAEIRAQAPLVRASYPWGAVQWLATR

YSDVKAVLTDPRLVNNPANVPEMHLPHPYEQALGDGGIPDEYVRYLAGSILSQDGPGH

LRLRRLSSRAFTVRRVNALRPRVTELAHRLLASLPDRAQDGVIDVLEDFSYPLSIDVI

CEIVGIPEEAREQWHTWGSAFYTMDPAVIGPAVRGMADHLHLLIEQRRATPTGDLLTG

LVQAEDEQGEPLTDEEIATLVLTFVTAGNETTAHLIGNGVAALLTHSDQLALLRSDRR

LLSQAVDELMRWCTPVQVTQPRYATEDLDVGGVTVRKGEQVVAVIGAAGHDPDRFPDP

ERFDITRNHRAPHEAHVGFGFGPHYCLGAALAHQETAIALDTLFDRFPSLALAVPPSA

LERQPFPGAWRLKSLPVRL

 

>CYP107D1    Streptomyces antibioticus

MTDTHTGPTPADAVPAYPFSLPHALDLDPHYAELRRDEPVSRVR

LPYGEGTAWLVTRMSDARIVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHT

RLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICEL

LGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLGA

LALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVADPAL

VPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHA

DELDFHRERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWK

QGMLIRGLERQIVSW

 

>CYP107E1    Micromosospora griseorubida

MTSAEPRAYPFNDVHGLTLAGRYGELQETEPVSRVRPPYGEEAW

LVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAF

TARRAESLRPRAREIAHELVDQMAATGQPADLVAMFARQLPVRVICELLGVPSADHDR

FTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDS

LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELIPSAVEELTR

WVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN

QHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLE

LPVVW

 

>CYP107E2    Saccharopolyspora erythraea NRRL23338

MPEPRPYPFSAAERLNLDPFYARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFS

RAAVLEKDEPRMRPGITGGGILSMDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLV

DRMIEHGSPADLVEEFALPLPITVICELLGVPYEDRDDFREWSDAFLSTTKLTPEQVVDY

MDRMFGYMAGLIAKRRVDPQDDLMSALIEARDEHDKLTEQEMVQLAAGILVAGHETTATQ

IPNFVYVLLTHPDQLEGLLADLDGLPRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVR

AGEPVLVSASSANRDEAVFDDPDRLDLTRENNAHIGFGHGPHHCLGAQLARLELQVGLRT

LLTRLPGLRFAGGEDDVVWKEGMLVRGPSKLEVAWQSE

 

>CYP107E3   Salinispora tropica (marine actinomycete)

MTIDQEIRKYPFCESPGIGIDPTYGLLRSTEPLARVQLPYGEVSWLATRYEDVKTVLTDP

RFSRAAAQGKDQPRTREEMTYEGIIGLDPPDHTRLRKLAGKALTARRVNAIRADAQRIAN

EYVDEMIAKGSPGDLVELFALPYPVTVICELLGVPFEDRAQFRIWTEGLTSTSEQLMVYA

EQLFGYMGKLVAQRREEPTDDLLGALVKARDEGDRLTEQELLSIAGVGLLLTGVETVSTH

IPNFVYALLTHPELMAQLRADRSLVPAAVEELLRMIPLNPAAMFPRYAVEDVTLSGITVR

AGEPVLVSLPGANRDPEVFENPETFDFTREQNPHVAFGHGPHHCLGAQLARMELQVALHT

VLDRFPDLSLADGDEGVSWKSGLLVRGPSRLLVAW

 

>CYP107E4 Actinoplanes sp. ATCC 53771

MTTTDTEFVAYPFNEDAGLELNEAYAAARATEGMLRVRLPHGEP                      AWLATRYADARFVLGDRRFSRAMAVERDEPRMAPGRRPGGILSMDPPDHTRLRTLVAK                      AFTMRRVELLRPRVAELASGLIQDMKAKGQPADLVEDYALPIPVAVICELLGVPVEDR                      PKFRVWSDAALSTSPLTTEEMMANQDELRAYMHVLVEQHRAEPQDDLMTALIEARDVR                      DRLSELELVDMCIGILIAGHETTASQIPNFVYALLEQPDQLARLRADLDLIPAAVEEL                      LRFIPLGAGAGFARYATEDIQVGDVLVKEGEPVMVAIGAANRDALQFTSADTLEFGRE                      SNPHLGFGHGVHHCLGAPLARLELQEALRALLRDLPGLHLDGDIVWKTQMLVRGPRSM                      PIGW

 

>CYP107E5 SBI_8067 Streptomyces bingchengensis

57% to CYP107E2 Saccharopolyspora erythraea NRRL23338 
VTTAETTVQSEAIAYPFNSSEGLGLSQAYQEARNRPGLVRVRMAYGEPAW

LVTRYAEARLVLGDRRFSRAAALHRDEPRQGEGRRNSGILTMDPPEHTRL

RTLVAKAFTVHQVEKLRPSVRQLTHELLDGLEAAGPPADLVDRYALPIPV

GVICRLLGVPEEDRPKFRAWSDAALSTSSLSAEEFDRNRDELRAYMAGLI

EIHRAAPQDDLMTSLIEARDAGDRLSELELVDLCVGILVAGHETTATQIP

NFVLTLLDHPGELRRLREEPALLNGAVEELLRFVPLGKGASQPRYATEDI

EVGGQLVRAGEPVLVAVGSANRDALRFDEPGKLNVARPATQHLGFGHGVH

HCLGAPLARLELQEALGALITRFPGLCLTGDVVWKDQMLVRGPRVMPVGW

 

>CYP107F1    Streptomyces griseus D45916

MENTSVQNKETVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMA

YGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSR

LRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPGDFVARVSAPLPLITICEAL

DIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTL

ATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRL

PRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPD

ELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNT

TSIWRYPLALPVTW

 

>CYP107F1 SGR6619 Streptomyces griseus 1 aa diff to D45916

MENTSVQNKETVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMAYGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSRLRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPADFVARVSAPLPLITICEALDIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTLATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRLPRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPDELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNTTSIWRYPLALPVTW

 

>CYP107F2   Streptomyces avermitilis

MTPSDEAIMCPFDFSKGLEFDPSLAELMARDSITRIRLPYGDAD

AWLVTGFDAVRQVTTDQRFSRAGIMGSDYPRLTPEPIVSPESINVVDPPHSSRLRRLV

SQAFTKGHVERMRRRIVRLADTLLDEMAAQGPPADLAHHLSNRLPQHTICDVLGIEQD

DWPRMEQYVHQLLSTGPDSRQSAATAKSELREYFGGLVEKRRSSPGNDLISALAAAKD

GEDVLDDQELAVMALTLMLSGHDTATCQISNICYLLLTRPELMKHLRSRPDTLTAVLN

EMLRFIPFRKGVGIPRVAVEDAEVDGVKIRAGDFVHVSYLTANRDPERYPDPDAIDPD

RPSLPHMTFGWGGHRCIAVPLAMAELEVAIGRLLERFPELRLAVPPEEVRWDTETIRR

FPIELPVAW

 

>CYP107G1   Streptomyces hygroscopicus

MSTTDQGETGKACPYPFAEMERLEIHPEYNRLRDAGELGRVLML

DGREAWLAASWEDVAKVFVDPRFSRSATLGKDVPRVLPAIQDQPVIMLMDPPEHTRLR

RVATKALTSRRMEALRPRTQEVADDLIDKMLAKGAPADLMEDFALPLPIIMICELLGV

PIEDQTKFRTWSDQMLSNGAYSQEVVMAAGQSLYLYLSELIAERRKQDTNDLLGSLVR

ARDKDDRLSETELVGFAVTLLIAGYETTANAIGNSVYTLLTHPEKLAELRKDLSLIPK

AVDELLRIIPIAKQASWVRMAVEDVELSGTIVKAGEAVAIQTHSANTDPKVYDHPEEI

DFHRTSNPHMSLGHGAHHCMGAQLVRVEMQTALGSLISRIPALRFAVPEPRIKFLRGR

LVPSLEALPLTW

 

>CYP107H1  Bacillus subtilis

MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG

YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP

RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE

WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD

KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL

RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP

HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV

TFE

 

>CYP107J1  Bacillus subtilis

MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL

GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP

DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS

EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD

LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ

QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF

PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM

KWKGNFLMRALEELPISF

 

>CYP107J2  Bacillus anthracis str. Ames

1 MAMKNKVGIR IEDGINLASA QFKEDAYEIY KESRKVQPVL FVNKTELGAE WLITRYEDAL

 61 PLLKDNRLKK DPANVFSQDT LNVFLTVDNS DYLTTHMLNS DPPNHNRLRS LVQKVFTPKM

121 IAQLEGRIQD IADDLLNEVE RKGSLNLVDD YSFPLPIIVI SEMLGIPKED QAKFRIWSHA

181 VIAYPETPEE IKETEKQLSE FITYLQYLVD MKRKEPKEDL VSALILAESE GHKLSARELY

241 SMIMLLIVAG HETTVNLITN TVLALLENPN QLQLLKENPK LIDAAIEEGL RYYSPVEVTT

301 SRWADEPFQI HDQTIEKGDM VVIALAAANR DETVFENPEV FDITRENNRH IAFGHGSHFC

361 LGAPLARLEA KIAITTLFER MPELQIKGNR EDIKWQGNYL MRSLEELPLT F

 

>CYP107J3   Bacillus cereus ATCC 14579

1 MKNKVGLSIE DGINLASAQF KEDAYEIYKE SRKKQPILFV NQVEIGKEWL ITRYEDALPL

 61 LKDNRLKKDW TNVFSQDIKN MYLSVDNSDH LTTHMLNSDP PNHSRLRSLV QKAFTPKMIA

121 QLDGRIQRIA DDLISDIERK GTLNLVDDYS FPLPIIVISE MLGIPKEDQA KFRIWSHAVI

181 ASPETPEEIK ETEKQLSEFI TYLQYLVDIK RKEPKEDLVS ALILAESEGH KLSARELYSM

241 IMLLIVAGHE TTVNLITNTV LALLENPNQL QLLKDNPKLI DSAIEEGLRY YSPVEVTTAR

301 WAAEPFQIHH QTIQKGDMVI IALASANRDE TVFENPEIFD ITRENNRHIA FGHGSHFCLG

361 APLARLEAKI AITTLFNRMP ELQIKGNREE IKWQGNYLMR SLEELPLTF

 

>CYP107J4P  Bacillus cereus ATCC 14579

1 MKEPQLQQHL EKFIQYIEAL VNEKRLNPDA DLISELVQTK EQEDKLSNNE LLSTIWLLII

 61 AGHETTVNLI SNGLLALLQH PEQMNLIREN PSLIPSAVDE LLRHSGPVMF ISRLASEDMT

121 IHGKRIPKGD LVLLSLTAAN IDPQKFTYPE TLNISREENN HLAFGAGIHH CLGAPLARLE

181 GQIALGTLLQ RLPNLRLAIK PDQLNYNHSK IRSLVNLPVV F

 

>CYP107K1   Bacillus subtilis

MQMEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATY

PAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHT

RLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELM

GIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKL

VHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMI

ATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEI

LNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKAAFEEIS

 

>CYP107L1   Streptomyces venezuelae

MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRV

RTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTR

LRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISEL

LGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALV

RTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLL

DGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHR

FDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPN

PMIRGLKALPIRWRRGREAGRRTG

 

>CYP107L2   Streptomyces avermitilis

MGNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEG

WLVVGHEEARAALADPRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAF

TMRRVEALRPRIQEITDGLLDEMLPRGRADLVDSFAYPLPITVICELLGVPDIDRVTF

RALSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAEDDDRL

SGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDGAVEEVLRF

EGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHRAPQGH

LAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW

 

>CYP107L3    Streptomyces tubercidicus strain I-1529

VSEDRIVDLAALGEEFTRDPHPVYAELRARGPVHRVRLPEGFEAWLVVGYEAARAALSDPRLSNDWRRAAGADEGD

PAAAPHMLISDPPRHTRLRRLVVKEFTPRRIEALGPRVREITDELIDAMLSRPGGRADLVEDFAFPLPAAVICELL

GVPYADRKTFHEWSTEVTKRSGGPRAEAAMGELAGYLMRLLEEKGRRPGDDLLSALIRTTGEDGDRLSSDELLGMA

VLLLIAGHETTAGLISNGMLALLRHPDQLAALQADFGLLDGAVEEMLRHSGPTGTSLHRFTTGPVDIAGTRIPGGG

ELVLIGNTPANHDPGRYPDPGRFDIRRDHRGHLAFGHGIHYCFGAPLARLEARTAIRTLLQRCPGLALDAAPDELV

WHHSAMMRGLPHVPVRTVPAPAAPAPQVHQVSSAH

 

>CYP107L4    Streptomyces tubercidicus strain R-922

VSEDRIVDLAALGEDFTRDPHPVYAELRDRGPVHRVRLPEGFEAWLVVGYEAARAALADPRLSNDWRHAAGAGAGD

PAAAPHMLISDPPRHTRLRRLVVKEFTPRRIEALGPRVREITDELIDAMLSRPDGRADLVEDFAFPLPAAVICELL

GVPYADRKAFHGWSTEVTKRSGGPQAEAAMGELAGYLVRLLEDKGRRPGDDLLSALLRTTGEDGDRLSSDELLGMA

VLLLIAGHETTAGLLSNGMLALLRHPDQLAALHADFDLLDGAVEEMLRHSGPTGTSLHRFTTAPVDLAGTLIPGGG

ELVLIGNTPANHDPGRFPDPGRFDIRRAPHGHLAFGHGIHYCFGAPLARLEARTAIRALLERCPGLALDADADRLV

WHHSAMMRGLPHVPVRVRPAPGTPAAQVHHASSAR

 

>CYP107L5   Streptomyces sp.

LIAGHETTVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAE 182

183 PLEIGGTVIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGFGTHRC 344

 

>CYP107L6   Streptomyces sp.

MGHEHVIDLGEYGPGFTENPHPVYAELRARGPVHRVRLPKHDAHHEAWLVVGYEEARAAL

ADPRLSKDGSTIGVTFLDEELIGKYLLIADPPQHTRLRGLIAREFTGRRVERLRPRVQEI

TDSLLDEMLPRGRADLVESFAYPLPLTVICELLGVPEIDRAAFRKLSTEAVAPTSGESEY

AAFVQLAAYLEELVEEKRCAPPADDLLSALIRTTDEDGDRLSPAELRGMAFILLIAGHET

TVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAEPLEIGGT

VIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGHGIHFCLGAPLARLEARVA

LRALLERCPGLTPDGAPGEWLPGMLIRGVRSLPVRW*

 

>CYP107L7P   Streptomyces narbonensis

MSRTHQGTTASRPVLDLAALGQDFAADPYPTYARLRAEGPAHRV

RTPEGDEVWLVVGYDTARAVLADPRFSKDWRNSATPPTEAEAALSHNMLESDPRCGPT

(deletion)

ALRADLTLLDGAVEEMLRYGGPVESATYRFPVEPVDLDGTVLPAGETVLVVLAD

AHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCTGAPLARMEARIAVRALLERCPDLALD

VSPGELFWYPNPMIRGLESLPIRWRSGREAGRRVPVEPACRP*

 

>CYP107L8   Streptomyces sp. HK803

MVTVDLSAYGPGFFTDPYPYYARLREAGPVHEIVLADGDRFWLI

VGYDEARAALADPRLAKSLDPPSEDERHVLITDPPDHTRLRRLVSREFTARRVEAMRP

RVQEITDGLLDEMVAGRRRADLVPSLGSPLPITVLCELLGVPLADREDFRGWTERVLV

PAEPDTIAWWKSRGFAQAGMALTDYLKNMIEDKRRSTPTGDLISSLLRTTAEDNDRLS

AAELHSMVFILIVAGHETTANLITNGVRALLAHPEQLAALRTDPEGLIDQAVEEMLRY

DGPVETSTKRFTLEAVRYGATKIPPGETLLVSIAATGRDPAQFERPDTFDIHRGTTGT

RSGHVAFGHGIHFCLGAGLARMESRVAILTLLRRCPDLALDIDPAGLDWLPGIRVRGV

RSLPVRW

 

>CYP107L9   Streptomyces peucetius

MTIVDLADYGPDFTANPYPYYERLRASAPAHRVRGADGGEFWLIVGHEEARAALGDARLS

KSPATMGTTMLDEQVIGPNLLVVDPPDHTRLRKLVVREFTPRRAEALRPRVQRITDDLLD

AMVPAGRADLVDALAFPLPIVVICELLGIPAADRDAFRTWSNEVVAPTSPETGEDAVRQL

GAYLDGLIADKRCAGPTDDLLSALIRTKDEDGDRLSFTELRALAYLLLIAGHETTVNLIS

NGVRALLAHPDQLAALRADFSLLDGAVEEMLRYDGPVETATVRFSAAPVPVGDLVIPPGE

VVL SAWRPPTATPPATPDPTASTSAGTPAAISPSGTASTSASALRWPAWRPGSPSAPSWS

AAPPSPWTKRRTRTNGSRAS*

 

>CYP107L10 SGR1278 Streptomyces griseus
MTTEPLVDLAALGEQFTRDPYPAYAALRAKGPVHRVRIPEGAEAWLVVGYEQGRALLADQRLSKHWSRASPSLGVSKVSAGSSMLGSDAPDHTRMRKLVAREFTPRRMEQLAPRVQEMTDGLLDAMLAAPDRTADLVEALSFPLPMAVICELLGVPSLDREAFRTWSGQAVSSVDPSLRASSTQAMTAYIAGLLADKRERPGEDLLSALIHTSDEDGDRLSGDELIGMAWLLLVAGHETTVNLITNGVHNLLAHPDQLAALRADFTLIDNAVEEILRFEGPVETPTYRFTTDPIEVGGTVIPGGGELVLVAMSDANRDPARYPDGSRFDITRDARGHIAFGHGIHYCLGAPLARIEARIAIRSLLERCPELRSAADPATLPWRTGILMRGPLSLPVGW

 

>CYP107L11 SGR1279 Streptomyces griseus

MAVLDLRDLPDFTTNPYPYYAKLRAEGPVHAVRTEEMEQRVWLVVGHAEARAALADQRLGKDWRHTGLWTESEAALSANMLELDAPHHTRLRRLVSREFTARRIEALRPRVTEITGELLDAMAPRGSADLVDALAFPLPMTVICELLGVPDIDRDAFRALSNGIVTPTPEQRGADPAGAMGAYLDGLIENKRRSPGDDLLSGLIRTGEADGEGLSSAELVGMAFLLLVAGHETTVNLIANGVRALLDHPDQLALLRADPGLLDNAVEEMLRYDGPVETATFRFARETLTIGDTEIHVDEPVLVALASADRDPLRFRDPDTFDIRREPQGHLGFGHGVHYCLGAPLARMEARIAIGALLERFPGLARDPSGGELDWLPGLLMRGARGLPVRW

 

>CYP107M1   Actinomadura hibisca

MPSSKDAPTVDPRPDVTPAFPFRPDDPFQPPCEHARLRASDPVA

KVVLPTGDHAWVVTRYADVRFVTSDRRFSKEAVTRPGAPRLIPMQRGSKSLVIMDPPE

HTRMRKIVSRAFTARRVEGMRAHVRDLTSGFVDEMVEHGPPADLIAHLALPLPVTVIC

EMLGVPPEDRPRFQDWTDRMLTIGAPALAQADEIKAAVGRLRGYLAELIDAKTAAPAD

DLLSLLSRAHADDGLSEEELLTFGMTLLAAGYHTTTAAITHSVYHLLREPSRYARLRE

DPSGIPAAVEELLRYGQIGGGAGAIRIAVEDVEVGGTLVRAGEAVIPLFNAANRDPEV

FADPEELDLGRTDNPHIALGHGIHYCLGAPLARLELQVVLETLVERTPALRLAIDDAD

ITWRPGLAFARPDALPIAW

 

>CYP107N1   Streptomyces lavendulae

MTGPEAAVRGCPFGAGEAPAYPFHAPDRLEPDPYWEPLRRERPL

QRVTLPYGGEAWLATRYQDVRAVFADRRFSRQLAVAPGAPRFLPHQPPPDAVLSVEGP

DHARLRRLVGKVFTPRRVEDMRPLIQRTADGLLDAMEEMGPPADLVEDFSLPFAVSMI

CELLGVPPEDRKRFCVWSDALLTTTAHTPAQVRDYMMQMHDYLGGLVAQRRVRPTADL

IGSLVTARDEEDKLTEGELVRLAEAILIAGYETSASQIPNFLYVLFRHPQLLERIRND

HDLIPDAVEELLRFVPIGTVDGFPRTATEDVELGGVLVRAGETVVPSMGAANRDPELF

TDPDELDLARRPNPHLGFGAGPHHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESL

SWKEGLMVRGMHTMPVTW

 

>CYP107N3 Streptomyces peucetius

VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW

LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT

PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT

WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE

LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV

DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP

HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*

 

>CYP107P1   Streptomyces coelicolor cosmid H10

MTAATDGPHVSGPAFDPWDPAFVADPYPAFAELRARGRVLYYEP

SDQWLVPHHADVSALLRDRRLGRTYQHRFTHEDFGRTPPPPEQEPFHTLNDHGMLDLE

PPDHTRIRRLVSKAFTPRTVERLKPYVHGLADDLVARLVAAGGGDLLTDVAEPLPVAV

IAEMLGIPESDRAPLRPWSAEICGMYELNPSEETAAKAVRASLDFSDYLRALIAARRK

EPGDDLISGLIAAHDEDDRLTEQEMISTCVLLLNAGHEATVNATTNGWLALFRHPDQL

AALRADHSLVPSAVEELMRYDTPLQLFERWVLDEIEIDGTTLPRGAEVAMLFGSANHD

PAVFTDPERLDLTRRDNPHISFSAGIHYCIGAPLARIELAASMTSLLKRAPGLRLAAE

PERRPNFVMRGLTELRVEL

 

>CYP107P2   Streptomyces avermitilis

MAAAFDLAFDPWDPAFLADPYPAYADLRAKGRVHYYEPTNQWLV

PHHADVSALLRDRRLGRAYQHRYTHEDFGRTAPPAEHEPFHTLNDHGMLDLEPPDHTR

IRRLVSKAFTPRTVEQLKPYVAKLAGELVDRLVAAGGGDLLADVAEPLPVAVIAEMLG

IPESDRAPLRPWSADICGMYELNPPKDVAAKAVRASVEFSDYLRELIAERRKEPGDDL

ISGLIAAHDEGDRLTEQEMISTCVLLLNAGHEATVNATVNGWYALFRNPDQLAALRAD

HSLVPAAVEELMRYDTPLQLFERWVLDEIEIDGTTVPRGAEIAMLFGSANHDPEVFRN

PEKLDLTREDNPHISFSAGIHYCIGAPLARIELAASMTALLEKAPTLGLVAEPKRKPN

FVIRGLEGLSVAV

 

>CYP107P3   Streptomyces peucetius

MLGIPVPDRPLLRPWSADICGMYELNPSQETAARAVQASVEFSAYLRELIAARRAEPGED

LVSALIAAYDEGDRLSEQEMISTCVLLLNAGHEATVNTTVNGWWTLFRYPEQLAALRADH

SLLSTAVEELMRYDTPLQLFERWVLDDIEIDGTLVPRGCELALLFGSANRDGARFDHPDE

LDLARQDNPHVSFGAGIHYCLGAPLARIELAAT

FGERCGSARRCGSRRSHGGRGAL*

 

>CYP107P4 SBI_9576 Streptomyces bingchengensis

75% to CYP107P1 Streptomyces coelicolor

MSSSAAPAPVFDPWQPSFVADPYPAYAALRERGRAHYFEASRQWLIPRHE

DVRVLLRDRRLGRTYLHRFSHEEFGRTAPPPEHEPFHTLNGHGMLDLEPP

DHTRLRRLVSKAFTPRTVERLAPVVERLADELVEAFVAEGGGDLVAAVAE

PLPVAVIAEMLGIPPADRAQLRPWSADICGMFELNPGDEAARRAVRASVE

FSEYLRELIAARRRNPGEDLISGLVAAYDEGDRLTEQEMISTCVLLLNAG

HEATVNSTGNGWLALFRHPDQLALLRSDPDALLPTAVDELLRYDTPLQLF

ERWVLDDIEVGGTVIPRGSEVALLFGSANRDPERFPDPDRLDLSRTDNAH

FSFGGGIHYCLGAPLARLELAASFGALLRRAPGLRPAAEPRWNPGFVIRG

LQELLVEV

 

>CYP107P7 SGR3408 Streptomyces griseus

MHVSFDPWSPAFVADPYPAYTALRAAGRAHWFEPTGQWLIPHHSDVSALLRDRRLGRTYLHRFSHEEFGRTPPPAAHEPFTTLNGQGILDLEAPDHPRIRRLISRAFTPRTVENLAPTVRRLAAELVDAFVAKGGGDLLAEVAEPLPVAVIAEMLGVPEADRGLLRPWSAAICGMFELNPSEETAEAAVRASVDFSAYLRGLIAERRADPGEDLVSALIAAHDEGERLTEQEMISTCVLLLNAGHEATVNTTVNGWRTLFHHPEQLAALRADPALLPSAVEELLRYDTPLQMFERWVLDDIELDGQVIERGAEVALLFGSANRDPERFARPDTLDLSRQDNPHLTFGAGIHFCLGAPLARLELAASFGELLRKAPALRMTAEPEWHPGYVIRGLKELRAEV

 

>CYP107Q1   Amycolatopsis mediterranei

PVPLSIVSRDRVSIQRLACKVFGETRSGPPGRASFVLIAPRRPQ

TVHKGHNSEHCQVGGCSTGRPLPTVRNRACRTRAGRPRRHQEGMAMTATAKPSAKPVD

LFSPEVVADPFGWYARLREEPLPHTGTLNLGTMMGGPDMWLATRYEDVLTVLTDPRFL

TNPPADSPLADIRDGVFKAMNFPEDLIPWMANKLNTADGEDHTRLRKLVSYALTARRV

NALRPRVEKITEDLFDRMAEQGKDGSPVDIVEEFCFPLPVTVICELVGIDEPDRAAWH

AWGNAMATMDGPKIPPALRECIALSRELMARRRVEPKDDLVTALVQAQADDPGRVSDD

EIVGILFSLVTAGHQTTTYLIGNSVLFLLEQPEQLARLKAEPALWAQAVRELQRLGPL

QFTQARFPSEDVELGGVTIPRGTPVAPLLLAANTDPRKFPEPDKLVVDRLSVANEMHL

SFGKGIHRCLGQHLAYQEAEVALHGLFTRFPDLALAVPRDEIPWILRPAFTRTKTLPL

KLA

 

>CYP107Q2   Amycolatopsis mediterranei

MTTTAETSAEPVDLFSPEVVADPWGAHAAVREAPTLQIGGFMGG

PPMYLAARYEDVRQVLMDQRFQCNPLADSPAEDIRNGVFRHLDMPEELIPWLKNLINA

SDGEEHARLRKLVSYALTAHRVGKFRPRVEELTAELLDKLEAAGGDGTPIDLVESFCY

PLPVTVICELVGVDHEDRPQWRAWSDAMATLDGKRLPEEVRKTLAAARGMIERRRAEP

KDDMVTALVEAQAKNPGIATDDELVGVLFSLVTAGHQTTTYLIGNSVLALHEHPDQLA

RLKADPSLWPQAVRELQRLGPIQFGQPRFATEDIEVGGTVIPRGMPVVPLIMAANSDP

RKFPEPEKLQIDRLAVGSESHLGFGKGIHRCLGQHVAYLEAEVALRGLYTRFPDMTLA

VPREEIPWILRPGFTRTKDLPVRLARPAS

 

>CYP107R1   Streptomyces maritimus

MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGE

AWLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVA

GVFTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDD

REQLRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDR

EEGLLRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVE

ELLRFIPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDID

RSPNPHVAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVR

GPKTLPVKW

 

>CYP107S1   Pseudomonas aeruginosa

VPDRKLRLGEELISPLHALYDGLQVDGAPRPAHRAAEHPVWVVTRYRDAR

KVLNHPGVRRDARQAAELYAKRTGSPRAGIGEGLSHHMLNLDPPDHTRL

RSLVGRAFTPRQVERLQPHIERITEALLDAMAGREQADLMADFAIPLTI

AVIFELLGIPEAEREHARQSWERQAELLSPEEAQALADAQVDYLRVLLE

AKRRQPADDVYSGLVQAADESGQLSEAELVSMAHLLMMSGFETTMNMIG

NALVTLLVNPEQLALLRAQPELLPNAMEELVRHDSPVRASMLRFTVEDV

ELDGVTIPAGEYILVSNLTANHDAERFDDPDRLDLTRNTDGHLGYGFGV

HYCVGASLARLEGRIAIQRLLARFPDLQLAVPHAELQWLPITFLRALIS

VPVRTGCSAPANTASHANPIERIAQ*

 

>CYP107T1   Streptomyces coelicolor 

MGSAPRLIVSLTGGPMTAPTYEELAALRAVGAVHRVFVPGSGESRLVVTRDAARAALTDPRL 16234

16235 RNDIRHSASWDSDGGHAIGHNMLQSDPPQHTRLRRLVAGHFTPGRTAALRPRVERIAHDL 16414

16415 LDALPPAGTADLVARYALPLPVTVICELLGVPESDRGTFHTWSNELVMPTSPEAAGSA 16588

16589 ATALTGYLTELTDAKRRTPDGTLLGDLVAAADSGELTPGELLGMAFLILVAGHETTVN 16762

16763 LISATVHGLLTHPGQLARLRAEPELTEAAVEESLRYHSPVHASAFRFAAEPLELAGTAIA 16942

16943 AGDPVLVSLAAASRDPAHFPDPDRFDIGRRPRGHLGFGHGPHHCLGAPLARVEAAVAVRL 17122

17123 LLDRHPALALAAGPATLTWRTSTLLRGLVELPVRLG* 17233

 

>CYP107U1   Streptomyces coelicolor

MTGSSSAPVPELFSWEFASDPYPAYAWLREHAPVHRTRLPSGVEAWLVTRYADAKQALADP 8557

8556 RLSKNPAHHDEPAHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEF 8377

8376 APRVQELADGLIDRFADTGSADLIHDFAFPLPIYAICDLLGVPREDQDDFRDWAGMMI 8203

8202 RHQGGPRGGVARSVKKMRGYLADLIHRKRAALPPEPAPGEDLISGLIRASDHGEHLTEN 8026

8025 EAAAMAFILLFAGFETTVNLVGNGTYALLTHPEQRERLQTSLAAGERGLLETGVEELLRY 7846

7845 DGPVELATWRFATRPLTIGGQDVAAGDPVLVVLAAADRDPERFTDPDTLDLARRDSQHLG 7666

7665 YGHGIHYCLGAPLARLEGQTALATLLTRLPDLRLAADPAELRWRGGLIMRGLRTLPV 7495

     SFTPPASSAGNGPSPTQK*

 

>CYP107U2   Streptomyces avermitilis

MAGSARRRGRHGGGVGTVAGSAAGTRRLQRERGSRYRHPVNAPH

SEPELFTWEFATDPYPAYAWLREHAPVHRTTLPSGVEAWLVTRYADAKQALADARLSK

NPVHHSEDAPGKSKTGIPGERSANLMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAP

RVQELTDHLIDQFAQTGSADLIHEFAFPLPIYAICDLLGVPREDQDDFRDWAGMMIRH

GGGPRGGVARSVKKMRGYLAELIHRKREALPADPGPGEDLISGLIRASDHGEHLTENE

AAAMCFVLLFAGFETTINLIGNGTYALLRNPQQRARLQQSIERGEQDLLDTGIEELLR

YDGPVELATWRYATEPLDMGGQRIASGDPVLVVLAAADRDPARFDEPDTLDLSRSDNQ

HLGYGHGIHYCIGAPLARLEGRTALATLLRRLPDLRLAADPADLRWRGGLIMRGLRNL

PVEFTAT

 

>CYP107U3   Streptomyces peucetius

MTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDAFIDKGEADLIHEFAF

PLPIYAICDMLGVPREDQDDFRDWAGMMIRHGGGPRGGVARSVKKMRGYLAELIHRKREQ

PGDDLISGLIKASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGVYALLCNPEQRERL

QASLAAGERGLLETGVEELLRYDGPVELATWRFATEPLTVGGQRIAAGDPVLVVLAAADR

DPERFADPDTLDLSRSDNQHLGYGHGIHYCLGAPLARLEGQTALATLLRRVPDLRLTGDP

ADLRWRGGLIMRGLRTLPVAWGAGGAPGGIKPGTAQTN*

 

>CYP107U4   Streptomyces scabies SCAB54411

MTNQPAPSSA VPTGTGAPEL FTWEFATDPY PAYAWLREHA PVHRTRLPSG VEAWLVTRYG

DAKQALADGR LSKNPAHHAE PAHARGKTGI PGERKAELMT HLLNIDPPDH TRLRRLVSKA

FTPRRVAEFA PRVQELTDRL IDGFADRGEA DLIHEFAFPL PIYAICDLLG VPREDQDDFR

DWAGMMIRHG GGPRGGVARS VKKMRGYLAD LIHRKREGLT DHPAPGEDLI SALIRASDHG

EHLTENEAAA MAFILLFAGF ETTVNLIGNG TYALLTHPEQ RARLQTSLAA GETGLLETGV

EELLRYDGPV ELATWRFATE PLTLGGQDIA PGDPVLVVLA AADRDPARFD DPDTLDLSRR

DNQHLGYGHG IHYCLGAPLA RLEGQTALAT LLTRLPDLRL AVDSADLRWR GGLIMRGLRT

LPVEFTPRKR S

 

>CYP107U5 SBI_8392 Streptomyces bingchengensis

80% to CYP107U2 Streptomyces avermitilis 
MSDRHHPACSPALFSWEFAADPYPAYAWLREHAPVHRTTLPSGVEAWLVT

RYADARATLADPRLSKNPIHHSEAAHAKGKVGIPGERSADLMTHLLNIDP

PDHTRLRRLVSKAFTPRRVAAFAPRVQELTDGLIDGFQRRGEADLIHEFA

FPLPIYAICDLLGVPREDQDDFRDWAGMMIRHGGGPRGGVARAVKRIRAY

LADLIHRKRESLRENAEGKAGEKADDLISGLIRASDHGEQLTENEAAAMC

FVLLFAGFETTVNLIGNGTYALLRDPAQCDRLRRAAQEGDEGLLATGVEE

LLRYDGPVEISTWRFATEPVVIGGQRIAAGEPVLVVLAAADRDPERFDSP

DVLDLSRADNQHLGYGHGIHYCLGAPLARLEAQTAIGTLLRRLPDLRLAV

EPEEIRRRGGLIMRGLRELPVTWGPII

 

>CYP107U8 SGR4436 Streptomyces griseus

MNDSPAPRPSEPSACPHSPAGPHGAPELFTWEFATDPYPAYAWLREHRPVHRTALPSGVEAWLVTRYGDAREALADARLSKNPANHAESPHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDDFVEKGSADLIHDFAFPLPIYAICDLLGVPEEDQDDFRDWAGMMIRHGGGPRGGVARSVKKMRGYLAELIHRKRENPGDDLISGLIRASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGTYALLRHPGQRARLEASLAAGESALLATGLEELLRFDGPVEMATWRYATEALTLGGEEIAAGDPVLVVLAAADRDPARFTDPDTLDLARRDNQHLGYGHGIHYCLGAPLARLEGQTALTTLLRRLPDLRLAGEPGDLRWRGGLIMRGLRTLPVAFEPGSRTRKSDTASTL

 

>CYP107V1   Streptomyces avermitilis

MSGASARCPFSGAGGGTDVLPLPADPGTAAGAPAPGPPDAPAAP

APRTADRSAPHAADPHAPSTADLPRFPFPGLSGIPLDPVLLDRYRGEPLVPVGLANGR

EALLVTRYADVRTVLSDDRFSREAWANGTLFARRSGALALVTSDAPTHTRRRSRVQSR

FTHRRAEEDRPRIARIAAELLDSLQAADTGRPVDLIAEFTTPFPYRVICEMLGVPVAD

LDRLLPSVTVMMSAGRFSADEAARAHEVMYGYFFGQLAARREAIAAGCPGDDLLTSLL

SAPRETRLSDEEIVVFGFGLMMAGGETTASHLAMCVLQVLGTPGLADRLRRDASAVPA

VVEELLRWVWFAGTGGQPHVALEDVELAGRVLPAGQVVIPLTDAANRDPGVFPDADEF

RPDRAPNPHIGFGHGRHMCLGAAHARVELQEGLTAVLERLDHLELAVEPAELRWRDQM

FMRGVWELPVRWHTKEDGRC

 

>CYP107W1   Streptomyces avermitilis

MAEAPSEPIAFPFPDPPSVCELPPELAEIRDGQSVVEVKFPDGI

SGWMVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRK

LVTKAFTARRVETLRPRITELVGQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVP

AGDQDTFHAWSNALLGDWQQVVEKEAATVSLVNYFGELIAVKRENPADDLISELIAIS

DGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRDNREAIPKAV

DELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL

NVTRENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSAS

IIRGLESLPITW

 

>CYP107X1   Streptomyces avermitilis

MDPAEGLLADPYAVYDRLRDTAPVHRIAGTDGKPAWLVTRYDDV

REGLANPLLSLDKKHALPGNYRGLALPPALDANLLNMDAPDHTRIRRLVGRAFTLRRV

EQLREPVRETAHRLLDALGTHGSTDLIASYAAPLPITVICDLLGVPDEHRRDFRAWTD

PLVTPDPARPDVARESVVSLLGFFTGLLADKRKNPADDLLSDLIAVQEEGDRLTEDEL

MSLAFLILFAGYENTVHLIGNAVLALLRHPEQLAALREDPARLPDAVGEFARYEGPAL

LAIRRFPVRDVTIGGVTVPAGETVLLSLSAANRDPSRFPDPDRLDLGRDAAGHLALGH

GVHYCLGAPLARLETEVALAALLERFPDLALAETEPRRRPSLRARGLLALPVTY

 

>CYP107X2    Saccharopolyspora erythraea NRRL23338

MRPVEIDDEFVTCPHAAYARLREQGPVHRAVAPDGSRVWLVTRYDDVRAALADSRLSLDK

AHATDGYRGLSLPPALDANLLNMDAPEHTRLRRTVTRAFTAHRTELLRPRVQEIADELLA

AVAGQERAELMSAFAGPLPITVICELLGVDARDRPDFRAWTDEMLAPSTPDRARDSLRSL

YAFLVDLIARKRAEPGADMPSTLVGLRDEDGSLTEDELTSTAFLVLFAGYENTVNLIGNG

LAALLARPAQLAAVRSDRGLLPSTVEELLRFDPPPQLSIRRFPKEDLEIGGVRIPAGDTV

LLSLVSAHHDPARFTSPGELIPDRADNAHLAFGHGPHFCIGAPLARMEAEVAFSTVLTRF

PALSLAVDPAELRWRPSFRNRGLRELPVRLS

 

>CYP107X3 SBI_2046 Streptomyces bingchengensis

67% to CYP107X1 Streptomyces avermitilis 

MQNTANTAVPGPPEPFDTRVLLEDPHTAYAELREAGPVHRIPGPDGRPAW

LVTRYDDVRRALADPRLSLDKSNALPGNFRGFALPPALDANLLNMDPPDH

TRVRRLVTKAFTPGRVERMREPVRRAADELLDAVEPAGRADLIAAYAGPL

PITVICDLLGVPQRDRRDFRAWSDALIAPDPERPHVAKEAVGNMLRFYTG

LIASKREEPGDDLLSDLIAVRDDAVGGAGEGGDRLTEDELTSLAFLLLMA

GYENVTHLIGNAVLSLLDHPPLLRELRERPAGIAAAGGXAVEEFARHDGP

APLAIRRFPLEDVEIGGVTVPAGETVLLSLASANRDPGHFKEPDRLDPDF

GRLGHLAFGHGIHYCLGAPLARLEAETALAALLSRLPRLRLDISHTELRR

RPTIRARGLISLPVAW

 

>CYP107Y1   Streptomyces avermitilis

MDFGADPYPEYAWLRAEEPVRQVLEGRGLYGLLVTRYEDVRKLL

SDPRMSKDPRNAPLDWQEAGKGRPLEDRTGLGTHLLTTDAPEHTRLRRLVSTAFTARR

VEGLRAQVQHITDGLLDTIVPRGQAELIGDFAFPLAITVICELLGVPKADQDVFRQWT

KDFRRWTNTDSAQADRGDARPVGLRDLLEYLTRLVDKRRQDPADGLVDALIAARDDDD

RLNEAELLSMMSLLLVGGFETTVNLIGNGTLALLRHPDQLALLRERPELVDSALEEML

RYDGSFETATWRFPLEPIEVAGTRIEKGHPVLLSLASANRDGAKFPAPDDFDVTRADP

AHVAFGRGAHFCLGAPLARLEGRIAFHGLLRRLPGLALSVPPEQLRWQRSLTVRGLEA

LPVTFDA

 

>CYP107Z1    Streptomyces rimosus ssp. paromyceticus strain R-2374

MTTSPTESRAATPTGSTASPSTASAPATTPSAATSSDTTYPATTDRTTLPSYVGLHPGEPNLMEPELLDNPYTGYG

TLREQAPLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADKDPRARLIELFGIPEDLTPYLADTIL

TSDPPDHTRLRRLVSRAFTARRIQDLRPRVEQITDALLERLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDR

TLWRRFGADLASLNPKRIGATMPEMIAHIHEVIDERRAALRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGH

ETTAHLISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYAMEDTEVAGVQVRQGEALMFSLVA

ANHDPRHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLELALTPEQLEDQERL

RQPGTWRLRRLPLKLHARS

 

>CYP107Z2v1  Streptomyces albofaciens strain C-0083

MTTSPTESRAATPPDSTASPSTAAAPATTPSAAASPDTTSPATTDRTTLPSYVGLHPGEPNLMEPELLDNPYTGYG

TLREQAPLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADQDPRARLIELFGIPEDLAPYLTDTIL

TSDPPDHTRLRRLVSRAFTARRIQDLRPRVERITDELLARLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDR

ALWRRFGADLASLNPKRIGATMPEMIAHIHEVIDERRADLRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGH

ETTAHLISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYAMEDTEVAGVQVRQGEALMFSLVA

ANHDPRHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLALALTPEQLEDQERL

RQPGTWRLRRLPLRLHAES

 

>CYP107Z2v2  Streptomyces rimosus ssp. paromyceticus strain BOEH-4355

MTTSPTESRAATPPDSTASPSTASAPATTPSAAASPDTTDRTTLPSYVGLHPGEPNLMEPELLENPYTGYGTLREQ

APLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADKDPRARLIELFGIPEDLAPYLTDNILTSDPP

DHTRLRRLVSRAFTARRIQDLRPRVERITDELLERLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDRALWRR

FGADLASLNPKRIGATMPEMISHIHELIDERRAALRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGHETTAH

LISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYALEDTEVAGVQVRQGEALMFSLVAANHDP

RHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLALALTPEQLEDQERLRQPGT

WRLRRLPLRLHAQS

 

>CYP107Z3    Streptomyces sp. strain IHS-0435

MTELADSPFSEHVGKHPGEPNVMEPALLTDPFTGYGELREQGPVVRGRFADDTPVWFITRFEEAREVLRDHRFANA

PAFAAGGGSGDTPSNRLMEIMGLPEHYRVYLANTILTMDAPDHTRIRRLVSRAFTARKITDLRPRVEDIADDLLRR

LPEHAEDGVVDLIKHYAYPLPITVICELVGIPEEDRLQWRDWGSAFVSLQPDRLSKAFPAMIEHIHALIRERRAAL

TDDLLSELIRVHDDDGGRLSDVEMVTMVLTLVLAGHETTAHLIGNGTAALLTHPDQLHLLKSDPELLPRAVHELMR

WCGPVQMTQLRYATEDVEVAGVQVKQGEAVLAMLVAANHDPRHFADPARLDLTRQPAGRAENHVGFGHGMHYCLGA

SLARQEGEVAFGNLLAHYPDVSLAVEPDALQRVPLPGNWRLAALPVRLR

 

>CYP107Z4    Streptomyces lydicus strain NRAB-0114

MSASTSSPLSAHVGKHPGEPHVMDPALISDPFGGYGALREQGPVVRGRFFDDSPLWLVTRFEEVRQVLRDQRFVNN

PADPALGVAPEDSPQLRALAMLGIPEHLHGYLLNSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVAQITAELLD

RLPEHAEDGVVDLIEHFAYPLPITVICELVGIAAEDRPQWRSWGADLVSVDPDRLGRTFPAMIDHIHALIGQRRAA

LTDDLLSELIRTHDDDGSRLSDVEMVTLVLTLVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHVTQLRYAAEDVDLAGTRIRRGDAVQAVLVSANHDPRHYTDPERLDLTRQPAGRAENHVGFGHGAHYCLG

ASLARQEGEVALGALFDRYPDLALAVAPEELERTPVPGTWRLTSLPVRLG

 

>CYP107Z5V1  Streptomyces lydicus strain NRRL-2433

MSALPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFVDDSPVWFVTRFEEVREVLRDQRFRNN

PVSSAPDADPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVAQIADELLA

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA

LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHMTQLRYAAEDVELAGVRIRKGDAVQLILVSANRDPRHYTEPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVALGALLRHFPELSLAVAPDALERTPVPGSWRLNALPLRLR

 

>CYP107Z5v2  Streptomyces chattanoogensis DSM-40241

MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN

PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA

LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVALGALLRHFPELSLAVAPDALERTPVPGSWRLNALPLRLG

 

>CYP107Z5v3  Streptomyces lydicus strain R-401

MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN

PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA

LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVALGALLRHFPELSLAVAPEALERTPVPGSWRLNALPLRLR

 

>CYP107Z5v3  Streptomyces kasugaensis strain A/96

MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN

PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA

LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVALGALLRHFPELSLAVAPEALERTPVPGSWRLNALPLRLR

 

>CYP107Z6    Streptomyces sp. strain I-1525

MSALSSSPFAEHIGKHPGEPNVMEPALINDPFGGYGALREQGPVVRGRFMDDSPVWFVTRFEEVRQVLRDQRFVNN

PASPLLGSQVEEMPMVKLLEQMGLPEHLRVYLLGSILNSDAPDHTRLRRLVSRAFTARKITGLRPRVEQIADELLA

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRAWGADLVSLEPDKLSTSFPAMIDHTHELIRQRRGA

LTDDLLSELIRAHDDDGSRLSDVEMVTMVFALVFAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHMTQLRYASEDIDLAGTPIRKGDAVQLILVSANFDPRHYSDPDRLDLTRHPAGHAENHVGFGHGMHYCLG

AALARQEGEVAFGKLLAHYPDVALGVEPEALERVPMPGSWRLNSLPLRLAKR

 

>CYP107Z7    Streptomyces tubercidicus strain DSM-40261

MSAISSSPFAAHVGKHPGEPNVMDPALITDPFGGYGALREQGPVLPGRFMDDSPVWLVTRFEEVRQVLRDQRFLNN

PAASSPGHSIDESPTARLLDMMGMPEHFRPYLMGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVEQLADELLA

RLPEHAEDGVVDLIKHFAYPLPITVICELVGIPEADRPQWRKWGADLVSLQPERLSTSFPAMIEHIHELIRERRGA

LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLVKDDPELLPRAVHELL

RWCGPVQMTQLRYASEDVEIAGTPIRKGDAVQLILVSANFDPRHYTAPERLDLTRHPAGHAENHVGFGHGMHYCLG

ATLAKQEGEVAFGKLFTHYPELSLAVAPDELERTPVPGSWRLDSLPVRLG

 

>CYP107Z8    Streptomyces platensis strain Tu-3077

MSALSSSPFAAHVGKHPGEPNVMDPALIADPFGGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFLND

PTAPSLGRSFDDSPTARLLEMMGLPEHFRPYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLT

RLPEYAEDGVVDLIKHFAYPLPIAVICELVGIAEADRPQWRKWGADLVSLQPDRLSTSFPAMIEHIHELIRERRGA

LTDDLLSELIRAHDDDGGRLSDVEMVTMILTVVLAGHETTAHLIGNGTAALLTHPDQLRLLRDDPALFPRAVHELL

RWCGPVHMTQMRFASEDVDIAGTKIRKGDAVQLILVSANFDPRHYTDPERLDLTRHPAGHAENHVGFGHGMHYCLG

ATLAKQEGEVAFEKLFAHYPEVSLGVAPEQLERTPLPGSWRLDSLPLRLR

 

>CYP107Z9    Streptomyces tubercidicus strain NRAA-7027

MSALSNSPLAAHVGKHPGEPNVMDPALITDPFGGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFVNN

PAAPSLGRSIDESPAVRLLEMLGLPDHFRPYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQITDDLLT

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIAEADRPQWRKWGADLVSLEPGRLSTAFPAMVEHIHELIRERRGA

LTDDLLSELIRTHDDDGGRLSDIEMVTMILTIVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVHMTQLRFASEDVEVAGTPIHKGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGMHYCLG

ATLAKQEGEVAFSRLFTHYPELSLGVAADQLARTQVPGSWRLDTLPLRLG

 

>CYP107Z10   Streptomyces tubercidicus strain I-1529

MSALSSSPFAAHVGKHPGEPNVMEPALLTDPFAGYGALREQAPVVRGRFVDDSPVWFVTRFEEVRQVLRDQRFVNN

PAAPPLAPSAEENPLTRLMDMLGLPEHLRVYMLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLA

RLPEYAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRKWGADLISMDPDRLGATFPAMIEHIHEMVRERRAA

LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVQMTQLRYAAADVDLAGTRIHKGDAVQLLLVAANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVAFGKLLAHYPEMSLGIEPERLERLPLPGNWRLNSLPLRLG

 

>CYP107Z10   Streptomyces platensis strain I-1548

MSALSSSPFAAHVGKHPGEPNVMEPALLTDPFAGYGALREQAPVVRGRFVDDSPVWFVTRFEEVRQVLRDQRFVNN

PAAPPLAPSAEENPLTRLMDMLGLPEHLRVYMLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLA

RLPEYAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRKWGADLISMDPDRLGATFPAMIEHIHEMVRERRAA

LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLLKDDPALLPRAVHELM

RWCGPVQMTQLRYAAADVDLAGTRIHKGDAVQLLLVAANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVAFGKLLAHYPEMSLGIEPERLERLPLPGNWRLNSLPLRLG

 

>CYP107Z11   Streptomyces platensis strain NRAA-7479

MSALPTSPFAAHVGKHPGEPNVMDPALITDPFTGYGALREQGPVVRGRFVDDSPVWLVTRFEEVRQVLRDQRFVNN

PAAPSLGHAAEDNPLTRLMDMLGLPEHLRPYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADALLA

RLPEHAEDGVVDLIRHFAYPLPITVICELVGIPEADRPQWRTWGADLVSMEPDRLTASFPPMIEHIHRMVRERRGA

LTGDLLSELIRAHDDDGGRLSDVEMVTLILTLVLAGHETTAHLISNGTAALLTHPDQLRLLQDDPALLPRAVHELM

RWCGPVQMTQLRYAAADVDLAGTTIHRGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVAFGKLLAHYPEMALGVAPERLERTPLPGNWRLNALPVRLG

 

>CYP107Z12   Streptomyces tubercidicus strain R-922

MSELMNSPFAAHVGKHPGEPNVMDPALITDPFTGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFVNN

PASPSLNYAPEDNPLTRLMEMLGLPEHLRVYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADALLA

RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRTWGADLISMDPDRLGASFPAMIEHIHQMVRERREA

LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLVKDDPALLPRAVHELM

RWCGPVHMTQLRYATADVDLAGTPIRQGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG

ATLAKQEGEVAFGKLLTHYPDISLGIAPEHLERTPLPGNWRLNSLPVRLG

 

>CYP107AA1   Mycobacterium smegmatis

MTPYSRRDRNH

MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLT

DPRIGKDGAAASALFPPGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAF

TAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELL

GVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPAD

DVLSSLVHRRDGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRN

PEQLRAVRADRSLLPRAVEEALRFESPLNTATVRYTSAPVTVGDVEIPSG

ELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM

EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIAS

TMREWSGSLPSSGEADSSFAH

 

>CYP107AB1P    Mycobacterium smegmatis

MILDEQFAQDPEGLYRMLRSEAPVCEVELIGGVRGWLVTRYADVMALLKD

PRVSKDHTSALPRLAPDRVRPYISPQLHNHMLNLDPPEHTRLRRLVVQAF

TPKALARMQPVIDAIADELLDDIDLRSGDEPIDLMADYAEPLPIQVIAEL

LGVAVEYA*PFRAAVTPLLMSVTVEEKAESGRATIEILNAVIDEKIREPG

EDLLSGMIGASVDGHGLTRDELMAMCFLLITAGYETTVNLIGNGTLALID

NPSQLEKVRENPDLTAGAVEEILRFDGPVNIATWRYATADIDVDGVVIPA

NEQIFLSLLSANRDTGRFENADRFDIERNTRGHIAFGHGIHYCLGAPLAR

MEGVTAIGRIVQRYDSITLDPTAELRYHNGTLMHGLKSLPVRLTRVPQPRP

 

>CYP107AC1   Streptomyces atroolivaceus

MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGE

GWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSK

AFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDR

GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD

DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEEL

LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITRE

KNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGP

QRLPIAW

 

>CYP107AD1   Streptomyces hygroscopicus

MSGRHFEQGERGTAMADTPEEELRILDPQSVAQELRKHGPPRQI

TMHGTTAWLVSRYEEVRDCLGHPGMSPAAAYAASQGQTNPVSGLFEDTVAGTNPPQHT

RLRRLLAKAFTVRRVESLRPRVQEITDTLLDRIAVDGRADLVSALAIPLPMQVICELL

GVPIADRTEFHQWADLMLTPPLDPDTAARSQDASAKLWTYMEDLAEARRKAPEDDLIS

DLMSAHEDDRLSHREVVATARMMLIAGYELTGSFISNAVFSLLSQPDQMELLRKDPEL

AGRGLEELLRHAGPGILIVRFANEDVEIGSVSIRAGDQVLLDMDAAHSDPAHFTDGER

LDLTRDSAVHLQFGHGIHYCIGAPLARVEGQIALESLVRRFPGLRLSVPAAEISHSKN

PFIRSLTALPVEFEAQQPVAG

 

>CYP107AE1   Streptomyces sp.

VILLKSLAANGLTASSCFTVSPLPIRSASPSIAFLTSSSERDSGVRNDRPSDAQPAIARF

RFPTPPHPRNPTQPHPTPPRPSPTDDPLQAPTFFADPYPTYARLRDTAPVLKVPTGSGGG

GRHSYVVTGYAEAREAFTDPRLSKDTASFFAGRPSQRDLHPAVSRNMLATDPPQHARLRA

LVTKAFTTGAVARLRPYISSLVDELLDTWPTHGTVDLIADLAVPLPVTVICELLGVPDSD

RASVRTWSSDLFAAGDPQRIDAASHAVGDYMTALVAAKRTAPGDSLLDDLIAVRDGQDHL

SEDELVSLAVLLLVAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDS

PVGIATFRFSTEALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFG

HGIHRCLGAPLARAEAELALHAVITRYPQAALATPPETLPWRHTRLTRGLASLPITLRDH

PK*

 

>CYP107AE3 SGR420 Streptomyces griseus
69% to CYP107AE2

MNDASEDSRSAPDLSSGCTAPRPRCPVRAVTSGSDGRESYLVTGYAEARDALSDVRLSKDTAAFFAGKGSRRRLHAAVAHTMLASDPPRHTRLRKLVTGAFTSGSIAALRPSIARLTDELLDRWPAGGAVDVVAALAVPLPVMVICELLGVPETDRPRVQRWSADLFAAGDPGRTDAASHAVAAYMTGLIVSKRLHPGDSLLDRLIAARERGDRLGEEELVSLAVLLLVAGHETTTNFLGNAVLALLRHPAELNRLRGDPGTIPRALDELLRFDPPVSTSTFRFATEAMSLGGTEIPAGVPVLVDINAANRDPERFTAPDRLDLDRDATGHLGFGHGIHRCLGAPLAKAEAHIALRAILTRFPDIRLAVAADRLDRRRTRLISGLDSLPVLL

 

>CYP107AF1   Streptomyces collinus DSM2012

MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPN

GLRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPH

VLSVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLME

ALAFPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEA

KRNEPADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHP

EVREQLAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGA

AGRDPDRYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLR

LAADPDELSWRSSLMMRGLEELPVFTA

 

>CYP107AG1   Streptomyces atroolivaceus

MSTEVETEKPAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLP

FGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRT

LVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVP

EDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIEA

RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIPAA

VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV

IDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEWKADMIIRA

PRVMHVEW

 

>CYP107AH1  Streptomyces peucetius

VTTTQDPVTAAERCTADFRRNPHPVYASLRDTAPVCPMKPPHGVETYLITRYEDARAALS

DPRLSKDMYGAMDAYRRIFGDSSVSLDDNMLNADAPKHTRLRRLVNSEFTPRRVEALRPK

IQDIVDQLLDACPTGEPVDLLPAFAFPLPITVICELLGVPAEERPHMQRLSTTVAQTGFS

KESKQAQQKAEEDLHSYFTQLIARKRERPGEDLLSALTEARDKDGGLSENELVSTAFLLM

FAGHKTTAYLIGNAVHHLMANPAQLRAVRENPELVGPAVEELVRYDGSVESATFRFATED

VEIGGTRIPKGALVQISLLSANRDPRKFESPDEFDVRRPGNAQSGHLGFGHGSHYCLGAP

LARLEMQLALTTLFGRFPAIAPADPSAEAKWMEVPFPAFRGLAELPVVLCPES*

 

>CYP107AJ1  Streptomyces peucetius

MVNTGGEMPLATERLGDSFFQDPQGLFARLRSSAPVTPVITPEGTRVWLVTRYEDVRAAL

ADPRLAKDWVTHMTPDDFDINVDPVQAYLDQHMLNLDPPDHTRLRRLVVKAFTPRRVAAL

RPRISAVNGELLDAMADGPAETDLIEAFAFPLSVTVICELIGIPVGDRESFREWSGTLLS

SRGTREESRAAAVDMYEYFTRMVAERRRSPADDLLSALIAARDSGDSLSEHELLSMVFLL

LVAGHETMVNLIASGVLALLTHPAELGRLRDDPSLLPSAVEELLRYANPLNHATERFTLE

PVTIGDAIIPAKEWVMLATSSANRDASRFAD

ARPAGRGPGRVGPRRVRARDPLLSRRATG

AAGGRDRVRDAAVPVPGADAGGARVVAEVAALQPHPRAGGPPRPTALTRAGETCPARPDE

LGSTVDVADPKGRRPALPADG*

 

>CYP107AK1  Streptomyces scabies SCAB79691

MVLGAEFVRN PHEVNARLRE QGAVHEVVMP TGLKVWWVTR WEEGRALLAD ARLSKNVADA

GKLFERHQSD MSRQRDYSHV INRSMVNMDP PDHTRLRGLV AKAFTMRQVT GLRPWIEKIA

DEVLGSLEGR VEFDVIADFA VPMVRTVISE FLGVPVADRA EFCAHAAVLT SDGDRESAAE

ASNALAELVS RIVTAKRADL GEDLLSSLIL AADGSDRLSD DEIISFTVLL FVGGFDTTVN

LLGNGMLALL RNPDQLAAVR DDPALLAGAV EEFLRYDGSA NISHWRRTVE PVTVGEVTIP

AGEFVFIALG SANRDPARFP EPDRLDVTRS AQGHLAFGHG IHHCIGAPLA RAEGEIAFRR

LLARFPSLEL TVDPEELEWR PSMLHHGLRS LPVRTAQR

 

>CYP107AL1  Streptomyces scabies SCAB63301

MDTASASPAG NGTDTETAYE YPFHRPSAVE VPPVYEELRA KCPVAKVRLP SGDEGYVVSR

YDDARVVLAD PRFSRAAMLD EGAPRLTAAP PMPGSLFTMD APEHTRVRRL VSREFTARRV

QNLRPRIQQM TDELLDDMEK LSPPVDLNPA FAFPLPVMVI CELLGVPFED RDRFRGWSDA

FVSLTAHTAE EVMEQRMSMV QYLAQLVQRK REEPADDLMS ALVAVHDEDG DRLSEHELIT

MGITLLVAGH ETTVSMIGKC VLTLLRHPEH LAALRERPET IDQVVEELLR INPIGDGGPF

RVTLEDVEIA GTTIPKGSGV IAAVASANQD PERFGADSGV FDPARSSAGA HLALGHGAHF

CLGAALARAE LQIAVSSLIR RFPRLALADE VGNLSLTSGM MVHALSRMPV TW

 

 

>CYP107AM1  Streptomyces scabies SCAB44031

MSQVETSGGT ASGSGTASGS GSGTSGGDRT RTGAPPDDEV IRLPMTGEGP LDPPAAWERL

RERCPVATVE LPSGDRAKFV SRYDDVRALL SDPRFARPRA GDDSARLSAD GSGGVATDAS

AAYPLAIPEA GEPHLRWRRQ VGRYFTAKRM AALRPGMTRI AGSLLDDMIE RGQPADLKAA

LGFPLPVYVI CELLGAPAED RDLFSHWSDA FLNVSRFSKE ETRTAFTEFT RYMADLVAAK

RSEPGEDLLS MLVVDSTALP EAERLTDAEL LATGMGLLVA GHETTANMIG KMAALLLADR

RRWEQLLADP SLVRTAVEEV LRFDANLSAF GMRRQLSEDV ALGREVLPGG TTVFCGMSSA

NRDDRVFSSP AEMDLTRSPN PHLTFGAGPH SCLGQALART ELQVALEVLL HRLPTLELAV

PPAELRRLEG LLVGGLREVP VRW

 

>CYP107AM2 SBI_7397 Streptomyces bingchengensis

68% to CYP107AM1 Streptomyces scabies SCAB44031 
MSQNDPTVRLPLPTDGPLDPPPEWELLRGRCPVATVELPSGDTGTLLTRY

DHIKALLSDPRFSRPAPEDDSARIAPEGAGGVSTNSGMSLSLQSNGEGHQ

RWRRHVGKYFTARRVTALRPGMEEMAETLIDAMVQSGSPADLKAALGFPL

PVYVICNLLGAPAEDRDRFSYWSDAFLNVSRYSVAETGAAHEDFVTYMSE

LIAAKRAEPSEDLISTLIEESRAEGEGLTDLELRDTGMALLVAGHETTAN

MIGKMVAMLLADRTRWDSLLADPSLIRTAVDEVLRSDANLGGYGVRRYLT

EDYEVDGAVLPGGTTVFCGLSAANRDERVFADPDEMDLTRSPNPHLTFGA

GAHSCLGQSLARTELQVVLEVLLHKLPSLDLAVPVARLRQIEGLTVGGLR

EVPVRW

 

>CYP107AN1   Bradyrhizobium japonicum USDA 110

1 MVTPGSGAAI GVFVSCGNRF EVTMNEQAQP AGGDPLFNPL SPDFIRNPYP HYDRLRAIDP

 61 IHVTPFGQFV ASRHADVSLV MRDKRFGKDF VERSKRRYSE KIMDEPVFRS MSHWMLQADP

121 PDHTRLRGLV VKAFTARRVE DMRPRIQEIV DEAIDAVIDR GHMDLIEDFA FRLPVTIICD

181 MLGIPEDHRE VFYKSSRDGG RLLDPVPLTP EEIAKGNAGN MMAQMYFQQL FELRRRNPAD

241 DLTTQLVQAE EDGNKLTNEE LTANIILLFG AGHETTVNLI GNGLLALHRN PDQLALLKAR

301 PELMVNAIEE FLRYDSSVQM TGRVTLEDID DLGGRKIPKG ETVLCLLGSA NRDPAVYPDR

361 PDRLDVTRPN VKPLSFGGGI HFCLGAQLAR IEAEIAIATL LRRLPDLRID DVENPEWRPT

421 FVLRGLKSLP ASW

 

>CYP107AP1   Streptomyces rochei plasmid pSLA2-L

MNQPQLPEIPALNSELFHTDQYATYREILEQRPVTRVRFYDGSL

VWLVNRHEDVRAALTDPRLSNDPMKQSDIDLSAATGIPADLIEYFQRNMFRSDEPDHG

RLRKLVTREFTVRRINALRPRIRQIADDLLEKFAATGGGDLVEALARPLPLTVMCELL

GVPEEDRADFQTWSQHIVESSPEFAERNAVSYRSLFECVRSLIRRRRDEPGDDLLSAL

VDLRDVADRLSENELISTVFLLLVAGIETTVNVLGTGTFLLLTHPGELARLRADGALL

GPAVEEMLRYMAPIEITSRHTLEPVEIGGVSIDAQSTVLINLAAANRDPARFEDPQSF

RVDRNDGGHLTFGHGIHYCLGAALARAEAEVTFEALLERFPDLRLAASASDLTWRHAF

MRGPVELPVSWG

 

>CYP107AQ1   Saccharopolyspora erythraea NRRL23338

MFDTADPAFVADPYPCFAELRRRGEVHRHPGLGMAVAVSHAAASEVLRHRGLGRIWVDAQ

PAADFPAFNLLHRTSLLETEGAEHTRLRRSISAAFARGHVERVRPWVAGLADALVGGLVE

RGGGDVVEEVAAPLPVQVIAELLGVPESDRNLLRPWSNAIVKMYEPGLPERRRAAAESAA

AEFAEYMRALADRRRSAPADDMVSDLVAAEELSADEVVGTAVLLLMAGHEASVNLVANGV

LALLRHPGQWRRLVDDPGLVPTAVEELIRYDSPLQLFERTAVEDVVVAGHRVAAGSKIAA

LLGAAARDPEVFESPDVLDVGRQPNPHLGFGAGIHYCLGAPLARVEAAAALSALVRLAPR

LEQAGEPVRRPEFVIRGLRELPVSV

 

>CYP107AR1   Saccharopolyspora erythraea NRRL23338

VQPDQSPTPRPESRHSPAAACPHAAVHREERPGGLVTWQISAFSEARAALGDSRFSKDPR

RLGEALRAGGRSMFAEYGDNLLDNLLNSDPPDHTRLRRLVGKAFSPATIERLGPTTQRLA

DELVASMLPAGRADLLAQFAYPFAFGVIARVLGLPPDSYRIFQRWTESMTAPREQGTDRM

VAARHLCEHVTELVRRSREWLASAPAETLLDELVSARDDGDRLSENELVATVLLLIIAGH

ETTVNLIGNGVHALLQHPGQLALLRDHPDLIDGAVEELLRFQPPISKTTLRVTTTDVEVA

GTEIPAGSIVNVLVPAANRDQRQFPDADRLDITRPPSAHMSFGHGIHYCIGAPLARMEGR

IAIGALLRGLPGLRLAEPAAEIPWRASNILRGLQRLPVRFDSAGADDEVRDRRHAGAARV

HA

 

>CYP107AS1   Saccharopolyspora erythraea NRRL23338

MTESIQRDADSQEAACPHARAYPFGDPGALDLDPDYARVRDEEPLTRIRMPYGEQGWLVT

RYDDVRTVLADPRFSRSEVLKRDVPRPTPQQVERPGTLVTTDPPEHGRLRRLVAGAFTHR

RAESMRPRIRGVVDELVDEMLAGDKPADLVAAVSMPLPVNVICELLGVPREDRHVFHSGA

VLSDYTVPADEREATFKSLADYLAVLIAERRARPEGPGDDVLGALISARDTDGDRLSEDE

LIELWVDILVAGYASIMSVTPDMVVTLLTERDRWDGLVADPGGVPDAVEEMLRVMPTIIE

SGHSRVATEDVEIAGGTVRAGEAVLPCLPAANRDPAVFDAAEEMRLDRDAGKHIAFGFGP

HYCLGASLARVQLQSVLTALVRKVPTLDLVEAVREDSTRVAAAVQGQLLVTW

 

>CYP107AT1   Saccharopolyspora erythraea NRRL23338

MSVGDIDTPSGEFDFAANLLPFDPLDPAFQADPYPFFRLVRETAPALCTQPGMWVVTGFR

ECSAVLRNPKFGHGDGRLVASQITHDAEGNVVRPFVFMDPPDHTRIRSLVTKAFSARMVE

RLRPTAERLVGELLAAAMSGPADEPVDLMAELAFALPSNLISELLGMPPQDKPLFEQWSS

ALGRGLDPDFMLSPEEMQRRDQARTEFDGYFAELARRRRAEPADDLVSALVAVEEDGRNL

SMSELVSTCRLLLSAGYLSTAHLIGNGVNALLRHPEQFEWFRAHPDQVAGVVEELLRYDS

PVQTAGMRTALQDTEIGDQPVSAGEGAMLLVGAANRDPAAFPDPDRLDVSRKPERNLGFG

IGAHFCVGAPLARLTTQVALTALAGLRVELATDDAPRINNLVLRGFAELPVFLRAA

 

>CYP107AT2   Saccharopolyspora erythraea NRRL23338

MSTTEGAPPVDSNVVRQLLLFDPFDPEFRADPHRVYREIRESGPVTATPGGLWLVSGHRQ

VSAVLRDQAFGWGEAELAAGHFTTDDEGNTVRPLTFADPPEHTRIRSLVTSAFSARIVER

LRPRAQELARESLAAALAGGGSADVIQQVAYPLTGRLLCELLGVDPEYQERFRAWAEAMG

RGLDPDFMQSPDQLARREEARAHFHEYFAELAARRRAEPGDDLVSALVAVEQEGDRLTAT

ELVVTCTLLLSAGYATTVHLIGNGMLALLENPDQLAWLRANPGRVGDAVEEVLRFDGPIQ

LVSRVALRDTEVDGHAVAAGSPVLLLLAAANRDPAVFDDPDRLDVSRKPGRNLGFGVGIH

FCLGAPLARLTAQAALSLLVEHELVLDGPRPAPTGSLVLRGLAELPLRSA

 

>CYP107AU1   Saccharopolyspora erythraea NRRL23338

MTAGTNNAGRLGALAEAVLGYNPVDPEYHANAHEHHRRMAERGPIFRTPGGMWTAVSHAA

CSAVLRDDRFGHDPGSAAQNLFDSTQRPSVAQRSFEFMDGPDHSRLRRLVNRAFTARRVE

RLRPAVRTLADQLLTDVSGRIDVLADFILPLAMTTIVDMLGAPTEDNHLFRAWAEPIVRG

LDPDFLLSSSELAAREQANAEFAEYFDRLVALRRAEPKDDLISALIAVEDDGVVLSGNEL

ISMCLLLLAAGHESIMHLVGNGTVALLRDEDQLEHFRGHPGEVTNAVNELLRYDPPVVLL

VRTALADAEVLGNRVRRGEIVWLQIGAANRDPAVFPDPDRLDLTRDTGGSLAFGLGIHFC

IGASLARLEAAAALSALLHRDVALASEQLVHQKNVVIRGYEEVPVVLR

 

>CYP107AV1   Saccharopolyspora erythraea NRRL23338

MTTAEPAETGSLAELNLGMRLVLHGAVTWSIARLGDPVARLLHSPWRRDPYPIYRQLRAR

GPLVRSRLGVWAASTYEVCDAVLRDRRFGVRTSDGSYGDPTAAAVGLQLSLLELDPPDHT

RLRKLAAPAFRPRKLENYRQRIEDTAHELLDRALAKGEFDLIRDFATPLPIRVICELLGL

PELGAERLAVHGAALSGALDGIRSIRHLRRMRASTLELNELFGDLIEQRRRQPGEDIVSD

LVTALDQDRLDSTELVQMCDLLLVAGFETTVNLIGNGVLALLERPDQWRLLCDDPDQAVG

VVEETLRWDPPVQTTMRVAHEPVEVAGRLLPRNSAVLPMLGAAGRDPAVHFAPDRFDITR

GTRGDHLAFSSGIHYCLGAPLARLESEIAFRCLATRVPELRRSGALVRRPTSVIHGLSAL

PVAASKATAGGRR

 

>CYP107AW1   Salinispora tropica (marine actinomycete)

MESVTSTSAPPPVPYIADPYPALARIRANGPVSILHSDEGIPMWVIARYRNVRAALADPR

FGQDARRAQTLADNRVAGVTLGGDVIHMLNSDPPDHTRLRHLVQGAFTARRVAAMRPLVE

RITTSLLDGVGGRQTVDLVQDFAFPLPMLVICELLGFPAEERDAYRSWSTAILTHNDDPA

AFATALRDMTDYIEVQLRHRRARPGEDLLTELLAARDAGQLTDDEIVGMVFLLLIGGHET

TVNLLGTATLALVRNPDQHRWLLANPHALSEAIDEFLRYESPVAMATLRFTTAPVTVDDV

VIPAGELVLVSLGGANRDPDRFPDADRLILDRRDTGHLAFGHGLHRCLGAFLGKLEGEVA

LGALLGRYPGLTLAAEVRQLRWRDTIMLRGLESLPVSLHG

 

>CYP107AX1   Salinispora tropica (marine actinomycete)

MTSRPTAVFDQCLLRDPHSRYNALRDQAPVHHVLTPDGAPAWLVTRYNDVRAAFTDPRLS

VDKRFSGTDGEHGSSLPPELDAHLLNRDPPDHTRLRRLAAAACTPRRVADLHPAVERIVS

TLLDGLAGHDRAELIGSLASPLPLQVMHELLGLPTQANIDFRTWTNTLLSADANQPAQSR

AAMANMRRFLIEQLAHKRAQPGDDLLTGLLAAREDDDRLTDDELVAMVFLLMFAGYDNTA

ALIGTVTHALLTNAELHEAVRGGSLALDELIDEVLRWNPAFPLAVRRFAREPITIAGQTI

PAGDRIWLCLASANRDPAQFTQPDELGIIGLRRSHLSFGHGIHYCLGAPLARLQTTIAVT

SLLNRFPEMRLAVPAHDIRWRESFRLRGLIALPVYL

 

>CYP107AY1   Salinispora tropica (marine actinomycete)

MSQDPTMRAELAPIPRSGARLGQEYDQLRNAGDVHQVLLPDSSLAWLVTNPKLVSRALTD

PRLALNRRHSRGSWSGFALPPALDANLLNLDAPDHTRLRRLVGPAFSPQRVSALRPRIRR

TAEHLLDTLVATSGPVDLVTGYCTPLSVQVIADLMGVPEAGRADLRTWTDTMLTSYPPDR

DAIRQAVVELHGYVVDLIDTKRQQPGDDLLSALVTIEQDGDRLTRDELTSLAFLILFAGY

ENTANLIASTVLRLLDHGGLRGVQLPEAIEETLRLEPPAPAAVRRFPTEEMTIGGATIPA

GDIVLLSIAAATRGTAGNAARLAFGNGPHFCLGAALARVEAEEALTVLARRLPDLALALP

VAQVRWRPTFRTHGPAELLVTW

 

>CYP107AZ1   Roseiflexus sp. RS-1, complete genome.

MHHPTEPPPELWSAAAISDPYPIYDRLRAEQPIRWTGGDWQIFR

YADAQALLRDPRLGADRLQVDPQWLIASGLEPLFKTRDSMMLFADPPDHTRLRTLVHR

AFTPRVVESYRPLVQRIVDQLLDAAAARGAIELIGEFAYPLPVTVIAHMLGVPVNMHD

QFRRWSDSLAAFIGGTTRPEADVLPAALKAVLEMTDFFLALVAERRRAPRDDLLSALA

QAEDGGDRLSEQELVANSILLLLAGHETTTNLIGNGMLALMRHPDQFALLRDHPELTP

SAIEELLRYDSPVQVTSRRALTDIEFQGHRIEEGQAVTVFIGAANRDPAQYQDPARLD

VTRGDVRHLSFGHGPHYCLGAPLARLEGQVAISALVRRFPHMRTLDEQVVWRDNFALR

GLQSLHIELE

 

>CYP107BA1   Roseiflexus sp. RS-1, complete genome.

4472327  MTPTIVARLASPEFLADPYPVYRQLIEQTPVFWLPHANAPGGMWCIARYDDIAFVLREAPIFKDT  4472133

4472132  SRIAPPDTLTPLDRAMLQRDPPDHTRLRRLASHAFTPRRVHDLMPRIEQI  4471983

4471982  SLDLIERIGARGEADFIADYA  4471920

4471920  PLPIIVIAELLGVPFEDHEQFSTWSDQIMAGSDSVLGGEEAARQSHQAMASLVDYFTTLI  4471741

4471740  RQRRHSPRDDLISALIAAHDAGDSLSEDELLGMCVLLLIAGHETTVNLIGNGLLTLLRH  4471564

4471563  PDQLNLLRRQSEYLTSAIEEMLRYESPVQRSTPRFAAEPFVIGGEQIEAGQQISLMFGAA  4471384

4471383  NRDPAHFSDPDRFDITRQPNPHLGFGMGIHYCLGAPLARIEARVAFTHILERLPAIRLAT  4471204

4471203  DTPAWKPVTWLRGLKSLPVLV*  4471138

 

>CYP107BB1 PlaO2 [Streptomyces sp. Tu6071].

           ABB69746

  1 MDRVLDFLSS ADSAGELQPR LVELSRQETL PRVLLADGQE AWLVTRNEDV RTVLSDRSFT

 61 RDVMGERARQ AGETPDGARS VNMDGRPHNE LRALVSKAFT VRRIEAMRPR IQAWTDELID

121 AMEETGPPAD LVAHLAVPLP ALAICELLGF PVEDRQVLSG WCERITRLGE GGPDQRAWQE

181 LSAYIARRVP VERAAARGGL APETSILTRL VHAHDSEDAL SMEELLSLTV VVLAGGLETT

241 QTAIGAGMVR LFRNPAQLDK VRADPDLVVP AVEEILRYQP VIDVNRVQVA TRTVRLGGQE

301 IRAGDLVQVS VNAANRDETV FPDSERCDVT RGPNPHLAFG YGAHHCLGAA LARLELKTAF

361 STLLRRLPDL RPAVPLESLG WRGGHVTLGL EELPVAW

 

>CYP107BC1 PlaO5 [Streptomyces sp. Tu6071].

           ABB69764

  1 MTESLETTSP DPTRSGNSDT GATPGYTVPK QVNDMWREKP VRRFSMRDGR EAWLVTGRAE

 61 VRTVLADPRF SRVEARRLDA VMSPAVIFTR PGILDMDPPE HTRLRRLVAG EFSARRMRAL

121 RPRIQQIADE LIGTMKAAGP PADLAEGLSY PLPIAVICEI LGVPYADRER FRAWADRVSA

181 PGTQPQEAMA ALRSLFDYMG GLVDDKHAHP DGSLLHGLVT ARDEQGRLDN EELVTLGCGL

241 LLAGYETTAT MLGKGLLALL DNPDQLAVVR SDPRAVPAAV SEVLRHVTPG VDPHTGLIRA

301 TTADVELGGT VIPAHSVVVA CNTAANFDPA TFRDPDRFDV TRENAAAHLT FGHGMHRCVG

361 AQLAQIELEA AFAALFPAIP GLRLAVPADE ITYTQSTLIR GLRSLPVLW

 

>CYP107BD1 Frankia alni ACN14a

MAETGGFAEVGGVAQTGGAREIFDPRWRSDPYPLYRTLRESARCHWLSPARIGVLTRHADCVAVLQDSAW

GHVPMETSAFRPVTDQDEGLRSMLRANPPTHTRLRRLVSRAFTPARIARFRPMAEALAGELLAAAVDRGE

VDLVEAFTRPLPLRVICSLLGVPAHDEKVFSGWASALTRGLDPDQVLDPVERAQRTEATRAFADYFTALI

ARRRAEPADDLLSDLIAVQDQGDRLGADELLEICVLLLVAGYDTTVNLVANAVLALARDPGQYAALQANR

TLVPAAIEETLRHDPPVQWTGRTALTDTDLAGQAFRAGDGIILVAGAAHRDPAAFPDPDRFDLTRYASAS

APAARHLGFGHGLHYCLGAPLARLEAETMLTALLDRVARLEIVAEPTYRPHLAVRGVDALQIRLHPAG

 

>CYP107BD2 Frankia sp. CcI3

MDADSPSGAAAVGTPPAFGAFDPARRHDPYPSYHALREADPFYRLPLGAQQVTLLTRYQDCMHVLQDAAW

GRGEGGTNAWRSANSFDGGLRSLLGVNPPDHTRLRGLVSKAFTPRVISGLRPQITVLVESLLDAALAAGE

VDLIDAFARPLPLRIICDLLGVPVRDEETFRAWGTALTRGLDPDYLLTPDELALRGKATVEFDAYFTDLI

AARRARPTDDLLGLLVAVREQGDSLTEAELLELCALLLVAGYETTINLIGNAVLALLRDTDQLTALRADP

DLAPALVDETLRHDPPVQFVGRLALRGTEVAGHSFAAGEVGVIMLAAAGRDPRTFAEPDRFDIRRYAGPT

PAPRHLGFGLGIHYCLGAPLARLEAEIALQALVRRAGSLTPASDPPSYRPHLAVRGLETLPIRLSP

 

>CYP107BE1 Frankia alni ACN14a

MATVPASRSASERRSPLLAAFDAARQVDPYSTYRAIREADPLAGHDLAGHRVTLVTRHGDTAAVLQDPAF

GHGYKENISPFRPDGDADDGLESLLRSDPPDHTRLRRLVSRTFTPGTLVELAPDITSFVAGLLDAALEAG

EIDAIRALARPVPTRMICRLLGVPAADEKIFGEWSETLIRGIDPDFLLTPDEITERRRAARELDAYFRDL

IARVRVRPGTDLVSQLVAIHLGEDALTESEVLALCAVLLVAGHETTVNLIGGGVLALVQHPDQLALLRAD

PGLIPAAVEEMLRHDSPVQFIPRTALRDTEVGGRQFRRGEGALLLVGSANRDPDAFDEPDRFLVARYAGS

TPAARHFAFGTGVHYCLGAPLARMEAEIIFRLLLERTSELALIGSTPTYRNQSIIRGLQTLPLRLAA

 

>CYP107BE2 Frankia sp. EAN1pec

MTTVGGMDTSEGGTSAIIAAVTATRLADPYPRYREIREVGAFIPGEIADRTVTLVTRLAEASAVLAHPAV

GHGYTDGINYRTGMDDGLGSLLRADPPDHTRLRRLVGRAFTPAVIEALAPEVTSLANVLLDEAIERGEID

AVAAFARPLPLRLISRLLGVPAADEEEFGGWADALTLGLDPHYLLTDEAKAACNRAAVEFDAYFLDLIAR

RRKEPRDDLLSRLVAIHDRGDMLAERELLELCTLLLVAGYETTANLISGGILALTRNPGQLAALRADPAL

VGPAVEEMLRFDPPVQFIARTVLADAEIGGRPFARGDGAIMMIGAANRDPEAFDEPDRFLVARHTRSDRT

RRHLGLGVGIHYCLGAPLARLEAEIAFRALFSRTSSFALAEDTVAYREQIVVRGLKRLPLHLSA

 

>CYP107BF1 Frankia sp. EAN1pec

MSAAPQVVFDAFAPVYRSNPYPRYALVRESTALYPINPQIAMATRYEECSAVLTDALWGHGYEDGINPFR

PGVDPDDVPGSMLRMDPPDHTRMRGLVKRAFVPRHTEGLRPRVEGLVNELIDTAIEAGEVDLMEALARPL

PLTVIGDMLGIPPEDYTAVKKWSLEIVRGTDPDILQSPESLARRPEAMREFEAYFAGLIAQRRKDPRDDL

LSDLCAAQERDSVLSDREMLGLSVGLLIGGYETVSDLIGKGLVALLRNPDQVALWRSNPELAPYAVDELL

RYEPPVQFTHRVALEERELAGRAFARGEGVVVLIAAANRDPAVYSDPERLDITRFAGRSPAPRHLSLSEG

IHYCLGAHLGRLQTQIAVDTLLLRAPGLSLTDDEPVWRDTVAIHGLDTLPIRLRD

 

>CYP107BG1 Frankia alni ACN14a

MFPVPQVRGTEGAYEGAGFMTTAEIDGDRVDAHRVVDAHDVFDTAHRIDPYPRYRRLRQAGSPTPVRLGD

AEVTLMSRFSDCAAVLQSQAWGHGNVDRLSPFWDQQASLPGSFIRMDPPDHRRLRTLVNKAFSARMVADL

TPMITSLVDTLVDRALAAGGLDVISGLSAPLAQAMVGQRLLGVPAADAEMLRSWELAIARGTDPDALLSA

EDAARRDSAGANVVAYLQDLVARRKAHPEDDLLSRLVAVEESGEVLTAAEVLGICVLLLVAGMETSINLV

GNGILALLAHPDQLALLRARPELAPSAVEEILRYDTPTQFTMRVALTDTTVGERRFRRGDGAIVLMGSAG

RDTDVFDGGERLDVTRYAEPGRSPRHLGFSLGLHYCLGAPLARLEATTAIRTLVERAPALSLATDELSYQ

PSLIHRGLSSLPVDLSPAAA

 

>CYP107BG2 Frankia sp. EAN1pec

MVAAEVTAGVAAESAPVEFTAFHPTHKADPYAVYQRVREARPLCPFMLGDIPVTVLTRYADCEAVLQSDD

WVHGYDAGISPFRDGAASAPRSFLRMDPPDHTRLRGLVNKAFTPRIVNQMAPGIQALADRLVDGALATGS

IDVIGEYAALIASATLGHLLGVPDDVGASLRGWALAIARGTDPDNLLTEAELVARRQATQDFQAYFEELI

AQRRANPTDDLISRMAAARDRDDALSELELLGVSSLLVVAGMETSINYVGSAVLSLLRHPDQLALLRARP

ELLPSAVEEVLRYDPPTQFTMRTACRRTELAGHTFARGDGVLLVSAAAGRDPAAFTDPDRFDITRYHGPR

PARRHLGFSVGIHFCLGAPLARIEAAAAIGALVRRTTTLELAVDEAELVYLPSLIHRALATLPVRVR

 

>CYP107BH1 Frankia alni ACN14a

MPNRPPPLQEPAVDLGTDTSSVLAAGPATALTPPAALTVDQAALNIFDPAWHHDTFPNYQVLREAGPFAP

GPLGLRLVTRYREVEAILADSAWSHAEEGAIMHPDSDGSDLPTSFLWMEPPDHTRIRRLVGKAFSARRIE

ALRARVTEVAGGLVDAAIAAGEVDLVEAIAYPLPLTMIAELMGVPVADHAAVRSMSFGLARGLDPDVLLS

QAEIDLRRESAAAFREYFTDLVARRRADPADDLVSALALAEAEGDRLTADEMLSTLVVLLVAGHETTVSL

ISSTFLMLMRHPDQYAALRARPDLAAPAVDELMRYCTPSHLTTRVATRDVEVLGEQFAAGDGVIILLASA

NRDAGRYADPERLDLARYAGGAAVPRHLAFGRGHHYCIGAPMVRLEMELLLRTLARRAPRLTPLVDPPPY

RPNLVVRGIAELPVRIDG

 

>CYP107BH2 Frankia sp. EAN1pec

MTGPATSTPHAVAGAPAVPDAEAVLAQAVIESFDPAWRHDPYPAYGTLRRAGTFLPGPLAGTMLVPGHAE

CAAILADPVWSHAEESELLHPDSDVELPGSFLWMEPPDHTRLRGLVSRAFTPRTIEATRPLARRVVDGLI

DDALAAGELDLIEGLAYPLPLTMICELLGVPISEHPAVRRMSAGIARGLDPDVLLSPAELAARTAAVEEF

REFFGALVTARRADPRDDLISALAQVHAEGDRLTTTELLGTLLILVVAGHETTVNLIGNGVLALLRDPAQ

LDALRRDPGLALPAVEEILRFDAPAQVTTRTARAEVTVAGRTFTPGEAVICMLGSANRDPRAFDRPDEFL

VDRYAGGARVSRHLALGMGLHYCLGAPLVRLEVGEVLRGIATRLTGMTLLADPPPYRPNIVVRGMSSLPV

RVTGRPG

 

>CYP107BH3P Frankia sp. CcI3 YP_481037.1   ABD11308.1           

MDSAAPSLGAPDWPARSDPEMEPPGHTRLRGLVSKAFTPRTIEGMRPWAEQVVDDLLSRLIQR

GLTSLPLSLTPGGVA

 

>CYP107BJ1 Frankia alni ACN14a

MVTVQPASSEAYVPPNESSPEQTGARLLAKLFDPANRHDPYSIYTELRAAGPLHTGPFDLKLANRYADCA

AVLGSQEWGHDREPHQLHPTIPAEAFPASFLWMEPPDHTRLRGLVTKAFTARTVAALRPRIAALVDELLD

NALRQGEFDLIATIAYPLPLTVVCEILGVPAEDHPLVQVWSQALARAFDPDVLMTPEALAERNRAIPEFL

SYFRALVSRRRREATGDDLITQLAAVEEQGDRLTEEELLGTCVTLLIAGHETTVNLVGNGMMALIRHPDQ

VALLRERPELIGPAVDELLRYDSPIHMNTRAAKRELVVGGEVFAPGEGIVALIACANRDPLVYDDPERLD

VTRFHTSKPIARHLSFSLGHHYCLGAPLALLEMELLLAGVLDRVADMELLTDTPPYKPNMLIRGLAELPT

RFHAA

 

>CYP107BJ2 Frankia sp. CcI3

MAVTTDSVFAGADAGTGVAADHGKPLPDQAPDLLAALFDPANRPNPYPLYARLRAAGRLHETPFGLRVAT

RHDDCVAVLSNQSWGHDQEAHQLHPTLPAEEFPATFLWMEPPDHTRLRGLVSKAFTPGRVADLRPRITAL

VDDLLDTALRAGEFDLIETIAYPLPLTIICEILGVPAADHGIIQIWSQALARAFDPDVLMSPEALAERND

AIPEFLAYFRALVARSRRSGGDDLLSALAAVEEQGDRLTEDELLGTCVTLLIAGHETTVNLVGNGALALL

RNPDQTALLRDEPDLIRPAVDELLRYDSPIHLNTRAATREMTVGGRTFSPGEGVVALIACANRDPEAFDD

PDRLDVRRYVAGSGASRHLSFSLGHHYCLGAPLALLEMEIFLAGFLHRVRSAELLVDSPPYKSNLLIRGL

AELPVRFRG

 

>CYP107BJ3 Frankia sp. EAN1pec

MTTSTVVPTAGTGSSGPAGEESTALLAELFDPATRPDPYPVYSRLREAGALHATPFGLPVATRHADCVAV

LANQDWGHDLEAHQMHPTLPAESFPTTFLWMEPPDHTRLRGLVSKGFTPRSVQLLRPRITALVDELLDNA

LAAGEFDLVETIAYPLPLTVICEILGVPAADHPAVQVWSQALARAFDPDALMSPEALAERNRAIPEFLEY

FGALVERHRREPGDNLISALAQVEEAGDRLTADELLGTCVTLIIAGHETTVNLVGNGMLALLRNPDQLAL

LRAEPELIPAAVEELLRYDSPIHLNTRAAKRELEVAGRVFAPGEGVVALIACANRDPRAYPDPDRLDVRR

FTSSAGGPPARHLSFSLGHHYCLGAPLALLEMELLLAAFVRRVSHAEITDNNPPYKPNLLIRGLAELPVR

FRG

 

>CYP107BK1 SBI_9749 Streptomyces bingchengensis

42% to CYP107AN1 Bradyrhizobium japonicum USDA 110

MEMSIIFDPRDPSVRTDPYPIYRRLRETDPIHQSHFGYWILSRYADVDAV

LRAPGASSEFYRDRTWANRRGGPDSPLVQSVRKWMLMLDGPAHRRIRGAI

SKVFTRASVERLRPRIAAETARLLDAAGEGKTDLIHSLALPLPVTVTCEL

LGLPGSDRDQCRRWTEQISRVIDPSITAEDAVEMNAAEVEFREYVADHLK

ERRSAPRDDILSLLLHAEVDGGQLTEEEIIANVQFLFVAGHETTVNLIGN

GLLALLRHPDQLRMLRDNPEIITDSIDEITRYDPPVQIVSRLLTEDVPLT

DVTLPAGAKVMLLFGAAGRDPERYPDPDRLDLTRTGVKTLAFSGGPHYCI

GAALGKLETSMMLTELLRRYSTIELTGDDLVWRPNVSFRGLQELPLQLVR

>CYP107BM1  Streptomyces hygroscopicus ATCC 53653            ACEX01000414.1 3915-5168 (+) strand

MSENAMSENATHLTPEQVEDPVRGYADLRTRDELPH AVLPGLTTPVRLVTRYADVKAALTEPRLIRDRTRIPGDADEAQASDAQDELLEAASAGLP AEYVKYFAGHLALFDGEEHAHRRAPLTRAFTARRIAALRTFVERTADALVAEAEANGGTD LLGAFAYPLATQVICELIGVEERDRDQVCSWMRDFAFGDGSRAGEALVALVEYAKELIAR RRAEPTEDLISALLDGDQLTEDDLIGIVFLLINTGITPPALFLAHAALALLDHPEQAARL HAAPELLPRAVPELLRYVSIVRIGATLYATEDVDFAGTALRRGESVTVALLAADHDPEEF GDGAGQLDVGREFGRGDGHLAFGHGAHYCIGAALGRLVTSVVLDRLFVRHDGLRLAVPRA ELEFGHWPGDGFHLLRLPVRL* 

 

>CYP107BM2  Streptomyces sp. C strain C            ACEW01000053.1 15059-16303 (+) strand

MNETVHHLSPDRLQDPATGYAGLGDGDGLPRVVLPGLRTPV RLVTRYADVKAALTEPRLIRDRTKVPGATDGPDAQDELLAPLGDLPPEYARYVSAHLAFL DGAEHARLRTPLTRAFTARRVASLRPFVEESAARLIGELAGRKEADLLNEFAYPLATSVI CELVGVDEADRARVCDWIRDFAYGDGSRMGDGLAGVVEYVKALIARRTAAPADDLISALL GGAREGGAGALDEEEITAMVFLLINTGITPPALFLAHAVLALLDHPGQLDRLRAEPELLG RAVPELLRHVTLLRIGATLYATEDFVFAGTGLRRGDSVTVALLAANHDPAVYGEASARLD VTREAARGRGHLAFGHGAHHCIGAALGSLVTGVVFERLLVRRPVPELAVARGELEFGHWP GDGFHLLRLPVRL* 

 

>CYP107BM3 = old CYP107BL1 SBI_9870 Streptomyces bingchengensis

51% to CYP107L1 Streptomyces venezuelae 
MTQQPIVLPYGDPAFVADPFPFYRMLCQGQPGEDGPVRRAVIAGGLEVWL

VTPFEECLAALSDPRLSSDVRLATDPRLMRQLPVAERESVLGNMLRADPP

DHTRLRRLVSRAFTARRVAELRPHVQEIADRLLDAVVPTGRADLIEDFAL

PLPVTVISELLGVPTDDRRAFQRWVDHLLPWGAEPQDPAVVERAWRQMRA

YLTGLLATKRVRPGEDLLSALIEARDEQRRLTEDELVSMAFLLLAAGYIT

TVNLIGGGIAALLAHPDQLRTLRDDPALLPDAIEELLRYDGPVNPGVARF

ASEDVSIAGVDIPRGATVLVGSALADRDPERFPDPDRLDISRGDSAHLAF

GHGIHYCLGASLARMEGEVAIGTVLRRLPQLALSVAPGELRWRPTGLRGP

ERLPVTFTPGASLAAVPS

 

>CYP107BN1P   Frankia sp. CcI3              YP_483188.1              ABD13459.1              40% to CAJ61641 same as ABD13459              39% to CYP107AH1 Streptomyces peucetius MQQCLGEAMRSLHDCAVEMVLREREEPGNGALGALTVVRDEDGTGFSDEELVSTVLLTAIAGYESTVVQI GNGFLAMFRHPEQMEHLKRGRTDIAAAVEEILRYAQSSTGFAGMTYAMADVELGSVTVPAGATVFVSLDS AARDEAHVDSPQRFELSRGSARHHVTFGSGHHYRA 

 

>CYP107BP1P   Frankia sp. EAN1pec              YP_001505775.1              ABW10869.1              41% to CYP107AT1 Saccharopolyspora erythraea no heme signature MPSRDIAAAGYMRSPRAKSTESREILMSVDETTEGCVTDANGNLIAYGATSCMVSQLEPSTDVNVSPPAA APHTTFDEFHA FDVFDPEHWPNPYPRYAMARKARPLIRTPLGVHLVTRYQDCATILQDNNWSHAHKAELF HPGVEHVDLPTSFLWMDPPDHTRLRALVSKAFTPRTVANLRPRIEQLVKDLFDAIIEAREVDVISALAYP LPLTIIAELLGAPAEDHPDLQRWSRALARGFDPEPLLSP GNVTHAPMPPVSSWPTSADWAPGNGVSGTRR AGKHALSVVNPVSTRRRLVTAGVEETDDWSGWLRERRHDDIPLSQRENPHERAVRSTTNTAGRTSGRKGG PRSRRTEPGCRYRSACSCSRCRSCCRRCRTTPTSRAEQQIGVGATRR 

 

>CYP107BQ1P  Frankia alni ACN14a             YP_715801.1             CAJ64277.1             56% to CYP107L3 Streptomyces tubercidicus (N-term lower case only) MTIRTASQEVPMSPTDPIPLYgpqykrdpyplyrrlratgpvhrvrfpsgvigwlvtgyraahealndhr lgknHALGTSDALSALIDEEGLRHLDLFSLRDILGDLPYDDKRSSVSRRYGPTSEQLRAEVRSDEDTRRL YQGITRFLVEDTAEFVGSRSALQRECRQRAYGVIGRSRAWGRLVAEHHPRAVRLSIHPQRRGTSKFGIRL LESSDAWMTPWHATVLRRADGASELMRRADAQRLGRLVTRDGRPSHFQAHAAV 

 

>CYP107BR1   Pseudonocardia autotrophica NBRC 12743             AB456955             vdh gene for vitamin D hydroxylase,             50% to CYP107AF1 Streptomyces collinus MALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGP VWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLV GRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAED RDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDG DRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEF LRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDA SGGVFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLS

RMPVTMGPRSA  

 

>CYP107BR2   Geodermatophilus obscurus DSM 43160             CP001867.1             56% to CYP107BR1 MTAVDASVFEGSFWRDPYPAYERLRAQAPVREVALPRGGTTWLVTRYDDVRAAFTDPRLV KDHRATLPPEVRAQAPRLPGPFGSMMILLDPPDHTRLRRLVSRAFTARRTAELRPRIEAL AAALLDAVPETEPVDLLAGYAVPLPMAVICELLGVPDTDRDAFGTWSRALVDDQDDVDEQ QATAGLAQYLYALVETKRRAPDGALISALVEVSEAGDQLSTEEVVAMGVLLLIAGHETTA NLIGNAVLGVATDAALREHLLADPQRIPAAVEEFLRWDGPVHNAPLRFAAEDVEYSGTTI PAGSVVTLSVGAANRDPGRFDRPELLDPDRETGGHLAFGHGLHYCLGAPLARLEGEVALR SLLDRFPDLRLAVPPEELRHRRSVLVHALETLPVVLRPEAAGSASA

 

>CYP107BX1 SGR810 Streptomyces griseus

MHRLFFEEPGPPRPAELPGGDPAWLVSRYADVRQVLSDPRFGRARLYAPEAPALSGVPDLVNNPDLMFNQDGSDHLRLRRTLRRAFTPRAVARWRPWIAATVEGILDRLESRPQPADVVAEFALPLPVAVISRLMGLDESVWDRMRYWSEHAFSDGTHEREQVAAALKEFSAFGAHLLAERRSTPGEDLVSGLVTAADEEGGVPEAQLVSLVCGLVVGGHDSTMTMLGNALLYLLGERRETWPRLGADEEAAGLLVERLVHLVPLGDDRGSTRHAAEDVEVSGVRIPAGAIVIADCGMANRDPEVFPPATLYDLFAPLEAPTLSFGAGPHYCLGAWLARTELQLALHRLAARFPELRLADPVDAVVWRTGTTSRSPRRLGVRW

 
>CYP107BY1 SGR895 Streptomyces griseus 
SGR895 putative cytochrome P450 376-aa MW:41055.09
42% to CYP107L2 Streptomyces avermitilis

MTADPYPGYAWLREHDPVCPVGGPHVPGRMWLVTRYDDVRACLADRRLGSRAPVDPDPHPPGLSHLDGPGHARLRRLVAAAFTPAAVARLRDRTARTCAHAVESFAGRGHADLVAEYTREIPVAVMHDLLGVPETERAPAADVLDMWYRAKFRQPRDEASLAELLDYVGELVAYKRTHPGDDLTTRLIDSDALTGEELEVMVMTLIGAGHITTIQFLGTTVLHLLDHPGHRAALLRGDLDWPRAVNELLRLDSPSHVAEYRYAGEDMTLADARVGEGDVVLLSLAAANRDPDRFPDPGTLDLTRDARPHLAFGHGAHTCLGSHLVRLETEIAVTTLFGRLPDLALDIPGGEVAWGYAPTFRGPLALPVTFTPSTSR

 

>CYP107BZ1 SGR3274 Streptomyces griseus

MTGTQTLSKYWMLTNEFTQNPYPVLDHVRREGPVRELSFPDGGRAWVVTRYEEAKAALADPRLSRDIHVHYRLMSRRTGRALTPPPEEANHLANLEPPRHTPLRRAISFAFTPRRAEALRPKVERIADDLLDRLGEAPEAELIAGYADPLPVITIAELMGVPADAWPDFLRWSTALRTHSPTDGSGVLDRNVQELSAYMADLIARKEREPGEDLLSALIHAAPENRLTPTEILSTGFALMTGGNDTTASLVGGVIAALLTHPRERARLLADTGRWGKSMDELIRYVSPISNALQRVTTEPVDVGGVTIPAGEVVVVCVMSTNRDTGQFPGHPDRLDLDRVKPAHLSFGFGIHYCSGAHLAKVITEVSARRLFERFPAARLAVDPSRLRYQQNVVVRPLEALPVLLRP

 

>CYP107CA1 SGR6789 Streptomyces griseus
MTATGHEIRDYPFGPVDRLDLDPALVEICGEHPVLRVRLPFGGDGWLVTRYADVRAVLSDPRFSRSAAAGDHVPRTVAVAPPPTSIMGMDPPDHTRLRRRVMRAFTVRSIDALRPRIAEIVNDLVDTMTEGDGPADLAAVLTWPLPITVICEMLGVPRADQDRFTEWVDGLLILDDPERSADARRQLGDYLAVLIAQRRAEPTDDLLGELAADSGKDPLSEEELVGLGVSLLSAGQEATANQIGNFVYTLLTRPALWRELVADPSIVPRAVEELSRFIPISATAGFTRVATEDLELGGQLIRAGDAVVAELGMANRDSAVFDRPEEIDFHREQIPHVTFGYGIHHCLGAQLARVELRVVLETLVTRLPGLRLAVPADQLAWRTERLIRGVAALPVRW

 

>CYP107 fragment  Streptomyces noursei

63% to CYP107A2 Streptomyces rochei

WTTPTRWSCSAPSLICLPRHGRNTAHRRTSRSHHPGRARRHPDR

DTLIPARSTVFIAGAAANRDPQKFPNPDTFDITRNTQGHLAFGYGVHHCIGRPLAQME

GEVAITALLRRFPHLHLTTPSQNLTWRRSFLRGLTALPVTLN

 

>CYP108A1    Pseudomonas spp.

MDARATIPEHIARTVILPQGYADDEVIYPAFKWLRDEQPLAMAH

IEGYDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSL

TSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALY

YPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIAT

FYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS

GGAIIGLSRNPEQLALAKSDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKR

GDRIMLSYPSANRDEEVFSNPDEFDITRFPNRHLGFGWGAHMCLGQHLAKLEMKIFFE

ELLPKLKSVELSGPPRLVATNFVGGPKNVPIRFTKA

 

>CYP108B1    Mycobacterium smegmatis

MFLTPVKFSPSEVPD

MSTPVINDAARVLAEPRAYADEPRLHAALAELRSQTPVAYVDVPGYYPFW

AITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIRTLIH

MDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPECDFV

QEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSSAEEL

NAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGEYLNDVDCLSYYV

IVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMPLATEEIIRWSA

PVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEIFENADKFDVGR

DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEFMAT

TFVGGLKHLPIRYSVR

 

>CYP108B2    Mycobacterium smegmatis

MSTPTMDDAAKALADPTAYADDARLHEALARLRAENPVAWVDQAPYRPFW

AITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGLRTLIH

MDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGPECDFV

TDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGTTVEEQ

MAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDGELMSDMDTLSYYV

IVASAGHDTTKDAISGGLHALIENPGELARLKADPGLMGTAVEEMIRWST

PVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSGNRDEEVFTDPFRFDVGR

DPNKHLAFGYGVHFCLGAALARMEMNSLFSELLPRLDSIELAGEPELSAT

TFVGGLKHLPIRYSIR

 

>CYP108B3    Mycobacterium smegmatis

MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFW

AITRYADIMAIERANDLFTNSPRPVLMTAEEDEQQAAVGISTLIHMDDPQ

HRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGGECDFVQEITV

NYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALL

EMFQYFTELTASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAA

GHDTTSATISGGMLALLEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAF

MRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH

VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGG

LKHLPVRYALR

 

>CYP108B4   Mycobacterium marinum MM3999

MSAPTMDEAA LLADPLAYTD ETRLHAALTR LRAQAPVALV DVPNYRRFWA ITRHADVMDI

ERDNTLFTNW PRPVLATVAG DELQAAAGVR TLIHLDDPQH RVARAIGADW FRPKAMRALK

VRVDELAKNY VDAMMAAGPE CDFVQQIAVN YPLYVIMSLL GLPEADFPRM LKLTQELFGS

DDSEFKRGST SEDQLPALLD MFGYFNAVTT ARREHPTEDL ASAIANARID GEPLSDIDTV

SYYLIVATAG HDTTSATISG GLHALIEHPD QLARLQADPA LIPLATEEMI RWVTPVKQFM

RTASRDTVVR GIPIAAGESV LLSYVSANRD EEVFDQPFRF DIGREPNKHV AFGYGVHFCM

GAALARMEVG SFFTELLPRL KSIELSGDPQ FTATTFVGGL KHLPVSYSLV *

 

>CYP108B4 Mycobacterium ulcerans

MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDI

ERDNTLFTNWPRPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALK

VRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGS

DDSEFKRGSTSEDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGEPLSDIDTV

SYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMSLATEEMIRWVTPVKQFM

RTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYGVHFCM

GAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM

 

>CYP108B5   Mycobacterium avium subsp. paratuberculosis K-10.

MSTTTMDEAA KLLADPMAYT DEQRLHAALT HLRANAPVSW VEVPNYKPFW AITKHADVMD

IERENMLFTN WPRPVLTTAE GDEMQAAAGV RTLIHMDDPQ HRVVRAIGSD WFRPKAMRAL

KVRVDELAKI YVDKMLAAGP ECDFVQEVAV NYPLYVIMSL LGLPEADFPR MLKLTQELFG

SDDSEFKRGS SNEDQLPALL DMFGYFNGVT AARREHPTED LASAIANARV DGEPLSDIDT

VSYYLIVATA GHDTTSATIS GGLQALIENP DQLQRLRDNL DLMPLATEEM IRWVTPVKEF

MRTAAKDTVV RGVPIAAGES VLLSYVSANR DEDVFDEPFR FDVGRDPNKH LAFGYGVHFC

MGAALARMEV NSFFTELLPR LKSIELTGDP ELVATTFVGG LKHLPVRYSL A

 

>CYP108B6   Mycobacterium flavescens PYR-GCK

MSVRVADEAG KVFADPTAYA DEQRLHAAMT HLRANAPVSW VDVEGYNPFW AITKHADIMA

IERDNTVFTN SPRPVLTTAE GDAQHASMGV STLIHMDDPQ HRKVRAIGAD WFRPKAMRAL

KVRVDELAKT FVDQMYDRGG ECDFVQEVAV NFPLYVIMSL LGIPESDFGR MLTYTQELFG

SDDAELQRGT TMEERGLALF DMFTYFNELT ASRRAQPTED LASAIANARI NGEPLSDIDT

VSYYLIVATA GHDTTSATIS GGLQALIENP DQLARLQQAP ELLPLAVEEM IRWVTPVKEF

MRTAQQDTEV RGVPIAAGES VLLSYPSGNR DEDVFTDPFR FDIGRDPNKH VAFGYGVHFC

LGAALARMEI NSFFSELLPR LTSVELAGRP EHIATIFVGG LKHLPIRYSL TR

 

>CYP108B7   Mycobacterium vanbaalenii PYR-1

MSVRIADEAARVFADPSAYADEARLHAAMTHLRANAPVSWVEVPGYNPFWAITKHADIMAVERDNLVFTN SPRPVLTTAEGDAQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRVDELAKTFVDQMYERGG ECDFVQEVAVNFPLYVIMSLLGIPESDFQRMLTYTQELFGNDDAELQRGESMEERGLALFDMFTYFNEIT AARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIENPDQLQRLQQNP GLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKH VAFGYGVHFCLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR

 

>CYP108B8   Mycobacterium vanbaalenii PYR-1

MSTPTMNQESQEAAKVLADPTAYADDQRLHKALAHLRANDPVAWVDHPPYRPFWAITKHADIMAIERAND LFLSEPRPVLVTAEADDMARAQLEAGFGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKIRVDELAKRY VDKMRDIGPECDFVTEIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGATVEEQMAVLTD FFNYFGALTASRRANPTDDLASAIANGLVDGELMSDVDTLSYYVIVASAGHDTTKDAISGGLHALVENPG ELARLQGDLDLMPTAVEEMIRWSTPVKEFMRTAAEDTTVRGVPIAKGESVYLAYVSANRDEDIFDDPFRF DVGRDPNKHLSFGYGVHFCLGAALARMEINSLFSELLPRLDSIELAGRPELSATTFVGGLKHLPVRYSLR

 

>CYP108B9   Mycobacterium vanbaalenii PYR-1

MSTPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNE LWINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIY VDKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITD FFRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQD QLARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKF DVGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR

 

>CYP108B10 Frankia sp. EAN1pec

MDIEAAATVFTDPRAYADNERFHTATALLRRESPIHRIEHPNFHPFWAVTKHEDVMAISRASDIWINEPR

PALGPKPKDAERENIPIRSLVQMDAPDHPVYRHVSADWFKPAGVRRLRDRIAELAKRFVDRMADQGGECD

FFTDIVSHYPLYVILSLLGLPEEDFPRMLRLTQELFGADDEDLARDQDKQAQRAPLVDFFNYFQALIQDR

RENPTDDLGSVIANATIQGEQIGKLEAAGYYTLIATAGHDTTSAALAGGLHALLESPGQWQRLVDDPRMV

ATGVDEMIRWVSPVKHFMRTAREDTVVRGVALAAGESVLLSYPSANRDEDVFENPDTFDVGRSPNRHVAF

GFGAHYCLGTHLARLEGQALYAELVPRVRSIELAGTPEYMEALFVGGPKRLPIRYTMA

 

>CYP108B11 Frankia sp. EAN1pec

MGFRSRALVIDNIPNRRASALGSLPLGSPWRGTHEGGPGMDIAEAATVFTDPTAYADNQRFHTATALLRR

AAPVQRVEHEDFESFYAITKHDDVMTISRGSDIWRNAPRPALGPKPKDGRAAEDAPVRTLIQMDAPDHPV

YRHISAEWFKPLGVRRLAGRIAELAKRYVDTMADFGGACDFFADVACHYPLYVILSLLGLPEDDFPRMLK

LTQELFGANDPDMARGSGDEQALMAALLDFFTYFQALTADRRANPTDDLASVIANATIDGEPIGELEAIG

YYVLIATAGHDTTSSALAGGMHALLQYPDQWRRLSENPGLVPTAFDEMIRWVTPVKQFMRTAARDTEIRG

VPIAAGESVLLSYPSANRDEDVFDNPDTFDVGRTPNRHVAFGFGAHYCLGTHLARLEGQALYAELVPRLR

SIDLAGTPEYMETLFVGGPKRLPIRYTMT

 

>CYP108B12P  Frankia sp. EAN1pec  YP_001509055.1   ABW14149.1             67% to CYP108B7 Mycobacterium vanbaalenii PYR-1

MDLDEAGSVFTDPTAYADEKRWHTATALLRRHSPVHRVESAGFAPFWAVTRHEDVFTDPEAFDVGRTPNK HVGFGFGAHYCLGTHLARLEGRALYTELVPRLREVELAGTPEYMQTLFVGGPKHLPIRYTIT

 

>CYP108C1    Saccharopolyspora spinosa strain NRRL 18395

VNIKLMGAGRTLADPAAYANDDRIHKALALLRREAPVHWVEAPGYRPFWAITRHADVMEIERQPDLFRNAPRPILV

PDAMEKRTAAQGTNFRTLVSMDGAEHRQVRAIGTDWFGPGALRHLETRVTELARQYVDRMLEFDGECDFVTDIAVH

YPLDVILSLLGLPRSDFPRVLSLAKELLGNADQEINGGRGAEGFVAVQQELLTYFNELTAARRATPTTDLASAIAN

ARLDGALLSEFDAASYYILIATAGHDTTSASIAGGLQALIENPQQLRQLQDDLTLLPTAVDEMIRWVTPIKCFLRT

ATEDYVLRGTTIRKGDSVLLSYPSANRDEDLFEEPFRFDIRRTPNRHLAFGFGVHYCLGAALAKMEARAFFAELLP

RLDSVQLAGKAELFATNFIGGLKHLPIRYKLRPSV

 

>CYP108D1    Novosphingobium aromaticivorans

MTNTSRLTKRRRPRRSDGKREGFMDSIPMVPAEVGRAVIDPKSY

GTWEPLLDRFDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKST

VFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRK

IANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDE

DMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEP

MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPGIVEEAIR

WTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANRH

LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRW

KAA

 

>CYP108E1    Ralstonia metallidurans

MTIASDFDTELASHEIYSDPERMHEMFETLRREDPVHWTTAPGH

PPFWAVTKQADVIEVGKHPDVFIASPKSFLMNDVEQRVRIEETAATGGKLVRTMIHMD

DPDHKKYRGLTQSYFMPANIKRLESVIQERARALVGRLIEKGTSEFCSEIAVWYPLQI

VMTLLDVPESEHPYLLKLTQQFLAPKDPTLRRDGPDERGKGAVAKEYFAYFGKMLAER

RAAPLKEDLGSLIAHATVDGEPLPLMEAVSYYVILATAGHDTTSSSMCSGLYYLLTQP

GELDRLRARPELMPSAIEEMFRHGSPVKHFVRTATRDFELRGKKIQAGDEVALMYHSA

SFDEEVFDEPRSFRIDRGPNKHVAFGFGIHACLGQNLARASMRTFFTELLARTESIEV

VGKAEFIASNQVGGMKTLNIRVTPSKQSTTDRIEVAA

 

>CYP108F1X  = 108B4 Mycobacterium marinum MM3999

MSAPTMDEAA LLADPLAYTD ETRLHAALTR LRAQAPVALV DVPNYRRFWA ITRHADVMDI

ERDNTLFTNW PRPVLATVAG DELQAAAGVR TLIHLDDPQH RVARAIGADW FRPKAMRALK

VRVDELAKNY VDAMMAAGPE CDFVQQIAVN YPLYVIMSLL GLPEADFPRM LKLTQELFGS

DDSEFKRGST SEDQLPALLD MFGYFNAVTT ARREHPTEDL ASAIANARID GEPLSDIDTV

SYYLIVATAG HDTTSATISG GLHALIEHPD QLARLQADPA LIPLATEEMI RWVTPVKQFM

RTASRDTVVR GIPIAAGESV LLSYVSANRD EEVFDQPFRF DIGREPNKHV AFGYGVHFCM

GAALARMEVG SFFTELLPRL KSIELSGDPQ FTATTFVGGL KHLPVSYSLV *

 

>CYP108F1X  = 108B4 Mycobacterium ulcerans

MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDI

ERDNTLFTNWPRPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALK

VRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGS

DDSEFKRGSTSEDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGEPLSDIDTV

SYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMSLATEEMIRWVTPVKQFM

RTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYGVHFCM

GAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM

 

>CYP108G1    Caulobacter crescentus CB15

1 MTISTDIANT IIDPKAYADG DRIDQAFAHL RREAPLAVAQ PDGFDPFWVV TRHADILEVE

 61 RQNELFHNGD RATVVTTIEP DKKVREMMGG SPHLVRSLVQ MDNPDHFAYR KITQGALLPQ

121 NLRALEARIR EIARGFVDRM AEHGDRCDFA RDVAFLYPLH VIMEVLGVPE SDEPRMLKLT

181 QELFGNADPD LNRTGKSVTD VGEGVDSIQS VVMDFMMYFN AITEDRRANP RDDLATLIAN

241 GKINGEPMGH LEAMSYYIIA ATAGHDTTSS TTAGALWALA ENPDQFAKVK ADPSLIPGLI

301 EESIRWVTPV KHFMRTATAD AELGGQKIAK GDWIMLSYPS GNRDEAVFED PFTFRVDRTP

361 NKHVAFGYGA HICLGQHLAR MEMRVLWEEL FARLDHVELD GAPTRMVANF VCGPKSVPIR

421 FKMH

 

>CYP108G2 Ectocarpus bacterium, 67% to CYP108G1 Caulobacter crescentus AE005918

159023 MIDPNIPDDIAITVVDPRSYADGNAIDEAFAKLRKDTPLGVAGPQGFEPFWVVTKHKD

       IVEVERNNEVFHNGDKSTTLVDANTDTA 158766

158765 VREMMGGSPHLIRSLVQMDNPDHKNYRGITAANFMPQELKALEVQVRKIAKSFVDHMEEL 158586

158585 GRKNDGRCDFAKDVAFLYPLHVIMELLGVPQSDEPKMLKLTQELFGAADPELNRTGKE 158412

158411 RDDPKEALAALSGTVAEFVEYFTAVTEDRRKTPRADIASVIANGKVNGEAIGIFEAMGYY 158232

158231 IIVATAGHDTTSGTTAGTMWELAKDRQKFLQVKNDPKLIPLLVEESIRWVTPVKHFMRSA 158052

158051 TQDTVLGGQEIKKGDWMMLCYQSGNRDEDVFDDPFEFKVNRQPNRHIAFGHGAHVCLGQH 157872

157871 LARMEMRALWEELLPRLDSVELDGEPTRMLANFVCGPKSVPIKFKMS* 157728

 

>CYP108G3 ABS63163.1 Parvibaculum lavamentivorans DS-1

CDS complement(1684831..1686087) locus_tag="Plav_1544"

56% to CYP108G1 Caulobacter crescentus

MTDKTIDNAIVNPKTYAHVDEFHRLFTQLRKEEPVRWTEPDGFRPFWTVSKHADIMEVERQNDKFLNDPR

LTLQTIEVEEEVKKFTGGNSKLIRSLVDMDNPDHRNYRGLTQAWFMPPNLKAISARVEALAEKYIDRLEA

KGGECDFVSDVAVWYPLRVIMTVLGVPAEDEPIMLKLTQELFGSTDPDMKRPDATETVNTVTEFFNYFTA

MTEDRRKNPKDDVASVIANATIDGEPIGHLEAISYYIIVATAGHDTTSSTAAGGLLALMQNPEEFAKLKA

NPEGLLGGAIDEMIRWTTPVKHFFRTAAVDYELRGQKIKAGDNLLMCYWSANRDEEAFDDPFSFKIERSP

NKHLAFGYGAHLCLGQHLAKMEIRALYKELLARLDHIELAGDPAWVEASFVSGLKRLPIRYSMKRKAA

 

>CYP108H1 Ectocarpus bacterium, 49% to CYP108G1 Caulobacter crescentus CB15 AE005918

1535540 MGAASHKAQTSLSELVAPIFNPASFSHRDKIDG

1535639 IFTTLRQDNPLACVEVPGYDPHWMVTKYSDVKEITRQDNLFHSGDRPKILHSQAGEA 1535809

1535810 LARSFTGGSPNLFQSLVQLDPPEHTAYRNVLQGEFMPGGIAKMKENVAKTAQEFVDQMAS 1535989

1535990 LAPTCDFADDVAMNYPLQVVLDIVGVPREHHPKMLQLTQWLFSYADPDLKRPGSDIT 1536160

1536161 DPEEIIKTWNVVFTQFHEFFMPLVEARRANPKEDIASLIANAKINGESMEERKMISYFG 1536337

1536338 ILATAGHDTTSATTALGMKMLAENPDMLARLKEKPDLIPSFVEECIRWGSPVQHFIRSAT 1536517

1536518 EDYVLRGQTIRKGDLLYISYLSANRDEEEFDDPFTFKMDRAPNRHVGFGFGGHVCLGQH 1536694

1536695 LARLEIRTIWQTLLPRLTEVELTGPVKFTESEFVCGPKSVPIRFKMDG* 1536841

 

>CYP108H2 Marine metagenome 1093018949056, AACY022454370, 57% to CYP108H1

APPRRGPQQSAEHTETWNRVYKEFEEYYEPVIKDRQTCPREDLASLISNGKIDGCPMEHR

AQISYFIIASTAGHDTTSATLATAISVLAERPEVLEQLKANLELIPAFIEETIRWASPVK

HFLRHATQDYELRGQQIKKGDLMYLSYISGNRDEDLIEDPFEFRIDRKPNRHVAFAFGNH

ICLGQHLARLELKIMLEELLPRLESLQLTGKPKLAISDLVCGPKSVPIQYDFKRTA*

 

>CYP108-un1   Mycobacterium smegmatis

LTDHYAMAHPKALNDTPDTAQPGQPQTRNPTTPGDLPPLQFFARTVHAET

SLGGVQFSENQRLVMNLAAANRDPRQFDDPESFDADRPRNPHVAFGGGLH

SCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLMAVISLPVA

FTPERSQT

 

>CYP109A1    Bacillus subtilis

MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESP

VRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAF

TPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLI

KTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQ

AEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVAN

VIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKI

DRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFV

FGVKRLPVRITFK

 

>CYP109B1    Bacillus subtilis

MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE

NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP

RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA

WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE

ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV

EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR

HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF

RVKM

 

>CYP109C1    Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_111

MNLFPDEMRR DPYPLYDQLR TGSPVFHVAP LDLWMVFDYD GVKRALTDHE AFSSAVAPPT 
GKAPDWIVFS DPPRHTKLRS IVLRAFTPRS IAGLEPRIRE LSRDLLDPWI ERGEMDLAAD 
YAGPLPTMVI AEMLGVPPED RARLLRFSEV IVNLSHAISG GEEAARAVSE HAVVKEEMKV 
YLAGLIEARR RAPAEDLLTR LVEAEVDGER LTEGDILNFF QFLLAAGTET ATNLIDNAIL 
CFLESPAELF RLRAAPELLP SAIEEVLRHR SPLQMVFRET RRAVEVHGQV IPAGKLVLPV 
IGSANRDPHQ FHDPGRFDIG RDPNPHVAFG HGIHFCIGAA LARLEARIAL PDLLCRLKGL 
RRASDEPWEP RKAIIVHGPA RLPIRFEPGR RAAVHAAGAH TPCPG

 

>CYP109C2    Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_8140

MNLFSEEMRR NPYPAYDQLR SRTPVLHYPP SDSWLIFDHD GVKRALHDHD AFSSVVSPPG 
TRTAEWLIFS DPPRHTKLRA LITRAFTPRA VAGLEPRIRR LSRELLDRTI ESGQMDVAED 
YAVPLPLLVI AEMLGAPAAD QPHFKRWSDA ILDLSHTVSG SEEAARALDA FTAVTAEMQA 
YLRGLVEQRR AAPEDDLLTR LVEAEVDGER LNEDEILGFF QLLLVAGHET TTNLIGNAML 
CFLENPDELA RLRAAPELLP SAIEEVLRYR SPVQAMFRVT RRDVPMHGQV IPAGKAVLAM 
IGSANRDSQQ FRDPDRFDIA RDPNPHIAFG HGIHFCIGAP LSRLEARVAL ADLVARLGGL 
ERASDAPWEP RRAIHVHGPA RLPIRFAPGP RLGGAPG

 

>CYP109D1    Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_4257

METETAPSPS PEQIDLSAPS VIADPYPAYR ALRGRSPVLY ARVPAGGAAG LGEPIRAYAL 
LRHAEVLAAL RDPQTFSSNV TDKIRVLPRI TLLHDDPPRH THLRRLVSRS FTPRRIAELE 
PWIGRLAASL LEATGDGPSD LMGAYAMPLP MMVIATLLGI PAERYVQFRS WSESVMSYSG 
IPAEERASRG KAMVDFFAAE LEARRRAPSG DLISALVEAE IDGARLDTPE AVGFCVGLLV 
AGNDTTTNLI GNMAHLLSER PELYRRAQQD RSLVGPIIEE TLRHSSPVQR LLRVTTRPVD 
VSGVMIPAGH LVDVVFGAAN RDPAVFEEPD AFRLDRPPAE HLAFGQGTHF CIGAALARME 
ARIALNALLD CYESITPGEA PPLRQTRAIM PLGFESLPLV LRRSRATA

 

>CYP110A1    Nostoc sp. PCC 7120 same as Anabaena sp. PCC

  1 MLTQLPNPIS VPSWWQLINW IADPIGFQKK YSKKYGNIFS MQLAGIGSFV ILGEPQALQE

 61 IFTQDSRFDV GRGNTLAEPL IGRTSLMLMD GDRHRRERKL LMPPFHGERL QAYAQQICLI

121 TNQIASEWQI GQPFVARSAM QKLSLEVIIQ IVFGLADGER YQQIKPLFTD WLNMTDSPLR

181 SSMLFLKSLQ KDWGTWTPWG QMKHKQRSIY DLLQAEIEEK RTKENEQRGD VLSLMMAARD

241 ENGQAMTDEE LKDELLTILF AGHETTATTI AWAFYQILKN VNVQEKLQQE LDRLGANPNP

301 MEIAQLPYLT AVSQETLRMY PVLPTLFPRI TKSSINIAGY QLEPDTTLMA SIYLIHYRED

361 LYPNPQQFRP ERFIERQYSP SEYIPFGGGS RRCLGYALAL LEIKLVIATV LSNYQLALAE

421 DKPVNVQRRG FTLAPDGGVR VIMTGKKSLK FEQSSKIFN

 

>CYP110A2    Anabaena variabilis (a cyanobacterium)

MLTQLPNPISVPSWWQLINWIADPIGFQKKYSQKYGDIFSMQLA

GIGSFVILGEPQAIQEIFTQDSRFDIGRGNKLAEPLIGRTSLMLMDGDRHRRERKLLM

PPFHGEKLQAYAQQICLITHQIASQWQIGQPFVARSAMQKLSLEVIIQIVFGLANGER

YQQIKPLFTDWLNMTDSPLRSSMLFLKSLQQDWGNRSPWGQMKYQQRCIYDLLQAEIE

EKRTKENERRGDVLSLMMAARDENGQAMTDEELKDELLTILFAGHETTATTIAWAFYQ

IFRNVNVREKLQQELDSLGENPNPMEIAQLPYLTAVCQETLRMYPVLPTLFPRITKSS

INIAGYQLEPNTTLMASIYLIHYREDLYPHPQQFRPERFIERQYSPSEYIPFGGGSRR

CLGYALALLEIKLVIATVLSNYQLALAEDKPIKVQRRGFTLAPEGGVRMIMTGKKSLR

FEQSNKIFN

 

>CYP110B1   Nostoc sp. PCC 7120 Same as Anabaena

1 MHLPKGPQTP VFVQVLRWVF SPMSFLEDCA KRYGDIFSVK LAKDVPAIVF LSNPKDIQQI

 61 LTNDNNQLDS PGDWNDLFEP LLGKRSVITL SGAEHQRQRQ LLMPPFHGER MRGYSQVITD

121 VTEKVISQHQ IGQPFQVRSV TQAITLRVIM QAVFGLYEGS RAEKLQHLLS DLLEKSSSPF

181 SVALLYFPSL RRDFGPIKFW GEQVQIQQQA DELIYQEIQE RRENPDPSRT DILSLLMDAR

241 DADGQPMTDV ELRDELMTLL VAGHETTATA LAWAMYWIHK LPPVKARLLE ELDSLGDNPD

301 STTIFKLPYL NAVYSETLRI YPVAMLTFAR RVIETMALGG YELPPGTPVL GSIYLTHHRE

361 DLYPEPKKFK PERFLERQFS PYEYLPFGGG TRRCLGLAFA QWEMKLALAK ILTSYELELV

421 NNSVEVRPKR RGLVTGPHRP IEMVIKSQRQ ITSRILETTT VS

 

>CYP110B2   Nostoc punctiforme

MKLPKGPQSPAVLQMLRWITSPMSFMETCAKRYGDMFTIRLDSK

SPPLIFVSKPEVLEQILTNDIKGLEAPGDTNLVFESLLGKHSVITISGAEHQRQRQLL

LPPFHGERMRSYSQIISDITEKVISQYQIGQPFNIRSVTQAITLRVIMQAVFGLDEGP

RAEKLQHCLAEMLEKGSSVLSAALLYFPALQRDFGPINFWGKQMRRQQAADKLIYEEI

RERQEQPDPSRTDILSLLMAARDEAGQPMTDEKLRDELMTLLVAGHETTATALAWAFY

WIQKIPTVRQKLLKELDSLGDNPDPSTIFKLPYLNAVCSETLRIYPVAMLTFARVVRT

PLSLGGYELEPGIGVIGSIYLTHHREDLYPEPKQFKPERFLERQFSPYEYLPFGGGAR

RCIGLAFAQLEMKLALAKILSTRELELVDNSEVRPKRRGLVTGQDRPIQMVVTSQRQV

KFPILQTATV

 

>CYP110C1   Nostoc sp. PCC 7120 Same as Anabaena

1 MKYQIQRPNP LKTHPFLQKL QWIADPVEYM KKASLQHPDM FTAEVIGFGD TVVFVSHPQG

 61 IQTLFANDRK KLVAVGEANR ILYPLVGNNS MFLLEGVKHK QRRQLLMPSF HGERMREYGH

121 LIRNITENLF SQLQQDVTFS ALTAMREISM QVILQAVFGF YEGERCQQFK HLLPIFLSEL

181 FQSPLASSIL FFPSLQKDLG NLTPWGRFVR QREKIDKLLY AEIAERRQEI NSDRIDILSL

241 LISARDETGD SMSDKELRDE LITLMISGHE TTGTAMAWSL YWILQTPEVF QRLIQELDSL

301 GDSPDPMSIF RLPYLTAVCN ETLRINPVAM LTLPRVVKEP IELLGNRLET STTVVGCIYL

361 THHREDLYPE SKLFKPERFL KREFSQYEFM PFGGGVRGCI GQALAMFEMK IVLATVLSRY

421 QLALADRKPE RPQRQGFTLT PTNGVKMLIT GQHKRQNYSM AASTTFNA

 

 

>CYP110C2   Nostoc punctiforme

1 MQLPNILKSP SLLQKLHWVS DPIGYMENAA QEYPDIFTGK IVGFGDTVVF VNHPQAIQEI

 61 LTNDRKKFTA VGELNGILKP LLGDNSVLML ESDRHKRQRQ LVTPSFHGER MQAYGQLICN

121 VSKKIFNQLP LNKPFVARNL TKEISLQVIL QSIFGFYEGE KIQKLRQLLP LLLELFESPL

181 SSSLFLFSFL QQDLGAWSPW GNFLRVREKI DQFLYTEIAE CQQQADPERI DILSLLISCR

241 DEAGQPMTDQ ELRDQLITLI LAGYDTTATA MAWGLYWIHK QPLVCEKLLQ ELDTLGDSPD

301 PMSISRLPYL TAVCNETLRI HPVTMFSFPR VVQEPLELLG HSLEPGTILL PSIYLTHHRE

361 NLYPQSKQFK PERFIERQFS PYEFLPFGGG VRRCMGEALA LFEIKLALAT IVSHYHLALV

421 DQRPEQPQRR GFNLAPGSGV KMVMTDQRAR KESLINMTTT PLS

 

>CYP110C3 gi|75908202| YP_322498 Anabaena variabilis ATCC 29413

95% to 110C1

MKYQIKRPNPLKTHPFLQKLQWIADPVEYMEKASLQHRDMFTAEVIGFGDTVVFVSHPQGIQTIFANDRK

KLVAVGEANRILYPLVGNNSMFLLEGVKHKQRRQLLMPSFHGERMREYGHLIRNITETLFSQLQQNVTFS

ALTAMREISMQVILQAVFGFYEGERCQQFKHLLPVFLSELFQSPLASSILFFPFLQKDLGNLTPWGRFVR

QREKIDKLLYEEIAERRQEINSDRIDILSLLISSRDETGNSMSDQELRDELITLMISGHETTGTAMAWSL

YWILQTPEVFQRLIQELDSLGDSPDPMSIFRLPYLTAVCNETLRINPVAMLTLPRVVKEPVELLGNRLES

GTTVVGCIYLTHHREDLYPESKLFQPERFLKREFSQYEFMPFGGGVRGCIGQAIAMFEMKIVLATVLSRY

QFALADGKPERPQRQGFTLTPANGVKMLITGKHQRQNYSTAASTTFTT

 

>CYP110C4 gi|119510163| ZP_01629302 Nodularia spumigena CCY9414

MSTPNRLKTPAFFQQLQWVADPVGYMEKAAQQYPDIFTAQVVGFGNNLVFVNHPQAMQEILTNDRKKLFA

GGKENKILQPLLGDYSMIMLDGDRHRKRRQLVMPSFHGDRMRSYGEIISNITEEVWSNLPTDKSFLARNV

TQDITLQVMIQAVFGVYQGERSQQLKKQLELMANIFRSPLSSSMLFFSSLQQDLGAWSPWGKFVRDRQEL

DNLIYTEIAERRQQNLENRIDILSLLMSAEDESGNPMTVQELRDELMTLLFAGYETTATALAWGLYFIQK

HPEVQEKLLQELDTLGDSPDPMSIFRLPYLTAVCNETLRIHPVAMLTFPRTVKEPVEISGYALDPGTILV

GSMYLTHQREDLYPEPKQFKPERFLERQFSPYEFIPFGGGVRRCVGEALAVFELKLVLATILSRYELALT

DDQPEVPRRRGVTLAPGRGVNMMITGQRLA

 

>CYP110C5 gi|67925622| ZP_00518945 Crocosphaera watsonii WH 8501

MKTIPTPKTPTLVQQLQWVLNPTGYLQTNHHRYPDLFKAKIIGLGNDIILISNPEIMQYILTHDRQEFTA

PSSLNTLLKPLLGDYSVVMLDGDGHRQRRQLVMPSFHGERLKVYGDLTCRITREAMEKLPENQPFLAREV

MQDISLKVIMEAVFGVTEGERYEELQYRLKELLDLFDSPITSGFLFFPSLQKDLGNWSPWGYFLRQRQAL

DKLIYAEISDRRANPDPERTDILSLLMFAKDEQGESMKDQELRDELITLLMAGHETTASAMAWALYWLHH

IPEIKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRLAQQTVEVGGYTFKPGDIVA

GCLYLTHLREDIYANPKQFNPQRFLDHKYSAYEFIPFGGGSRRCMGEALAKFEMKLVIAIIISEYCLKLA

DTQPEKQQRRGLTLSPKRGVKMILEGKRQPQKARELELSTR

 

>CYP110C6 gi|126660859| ZP_01731952 Cyanothece sp. CCY0110

MKTIPGSKTPKLIQQLQWIFNPTKYLKTNHRRYPDIFKAKIIGFGDKMILTSRPEIMQYILTHDRKQFTS

PSGLNAILRPLLGDSSVLMLDGDRHRQRRQLVMPSFHGERLKVYGDLTCRITEEVMAKVPQNQPFLAREI

MQDISLKVIMEAVFGVTEGKRYEQLQDRLKKMLDLFNSPLTSAFLFFPFLQKDLGSWSPWGHFLRQRQAI

DELIYAEISDRKAHPDSDRTDILSLLMSAKDEQGQGMKDQELRDELMTLLTAGHETTASAMAWALYWIHH

TPEVKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRVAQEKVEVAGYTFEPGDMIM

GCMYLTHLREDLYTNPEQFNPQRFVDRQYTPYEFIPFGGGSRRCVGEALAQFEIKLVIATIMSQYCLKLA

DTQPEKQQRRGVTLSPARGVKMILEGKRQPQPVRELELSRQ

 

>CYP110C7 gi|119486461| ZP_01620519 Lyngbya sp. PCC 8106

MKTLNSPKTSPLIQRLQWVFNPLEYMETNVKINRDIFNTQVTGGVGLIFVNSPEGMQELLTRDTKEFYAP

GSINEILKPLLGEQSVMLLDGDRHKRQRKLLMPPFHGERMRTYGELILNITQQATAKLKPGQPFIARNAM

QEITLAVILQAVFGIYEGSRYDKLKQLITSLLAVTDSPVSSSLLFFTSLQKDWGAWSPWGRFLRMRQKVD

QLLFAEIEERRQNWDENRTDILNLMMAARDEDGQPMADEELRDELLTLLVAGHETTATAMAWALYWIHRQ

PEVYQKLIQELESLPENADPMTIFRLPYLTAVCNEALRIYPVAMLTFPRVTKEPTQLLGYELEANIGLAG

CIYLLHHREDLYPEPKQFKPERFLERKFSPYEFLPFGSGARQCIGMALAQFEMKLALAQILLDYDLTLLE

KRPVKAARRGVTLSPVGGIKMMMNGKRTPSKSVAIPATV

 

>CYP110D1   Nostoc sp. PCC 7120 Same as Anabaena

1 MTVTQNLPNG PRIPRLLRLF KFITQPIQYV EDFAKVYGDN FTIWGSGESY FVYFSHPQAL

 61 EQIFTNVSCF ESSGGGSPLL ELLLGKNSLI LLEGDRHQRQ RQLLTPPFHG ERMRAYGQTI

121 REITQQVTQA WQMGKPFNIR ASMQEITMRV ILRVVFGVDE GELFQELRQL LTTLLDFMGS

181 PLMSSTFFFS FTQKDYGAWS PWGRMVRLIK KIDQLIYALI AQRRAEFGEN RQDILSLLIS

241 ARYDDGQPMS DVELRDELMT MLVAGHETTA SALTWAFYWI DSVPEVREKL FQELDTLNDD

301 SEPSIIAKLP YLTAVCQETL RFYPIVLNAF FRRTKNPMEI MGYKLPKATL VVPSIYLAHH

361 REEVYPQSKQ FRPERFLEKQ FSPYEYLPFG GGNRRCIGLA FAQYEMKIVL ATILSQFQVS

421 RLSKRPVQPV RRGLTLAAPG GMKMVANKRM RNS

 

>CYP110D2   Nostoc punctiforme

MNIPLSVTLSNMKSRNNKIQKPSNLQTPMTATYNLPDGPQMPRW

LRTIKFISQPVKYVDDFAKTYGDTFTIRSSRSDNHIVYFSQPQALEEIFTADSRHFEV

GRGNTGLRFLLGDRSFMLVDGDRHQRQRQLLAPPFHGERMRAYGEDIRKITQQVSHEW

KIGKPFNIRESMQEITLRVILRVVFGLNEGELFEELRRSLSDLLDFISSPIMSSAFFF

RFIQKDFGAWSPWGRILLQRQKVDLLIYTLLRERRAQTDQNRQDILSLMMAARYDDGQ

GMSDEELHDELMTLLVAGHETTASALTWAFYWIDHLPEVREKLLQELNTIGVNPDLSS

VAKLPYLTAVCQETLRIYPIAMTAFVRIVKTPITIMGYELREGTAIVPSIYLAHHREE

VYPQSKQFKPERFLERQYSPYEYLPFGGGNRRCIGMAFAQYEMKIVLATVLSEFQVSL

VNKRPVHPVRRGLTVATPAGMRMVATPQVKRANTPALV

 

>CYP110D3   Trichodesmium erythraeum

MTLPDGPSLSPLQRRLRTWKFIFSPLSAIEERYSEYGDIFRTNT

NSLYPFIYFCNPKAIQQIFTADPDTFTSGSINGILKYFVGLNSLLLQDGDRHKRQRKL

LMPPFHGDRMRKYGDLIYNITSNVISQWKIEQPFPIRKSTQEISLKVILAAVFGLDQE

GKSYEKLRVLMSDLLDSMSSPLSSTFLFFNFLRKDWGPWSPWGRFLRKKQELHELIIA

EIQTAKKEGNHRDDILSLLLEARDEAGNAMSDEEIKDELLTMLFAGHETTASALAWAL

YWIDMIPSVGEKLMAELATIPSNSDQVAITKLPYLSAICQETLRIYPIAMNAFPRVVQ

KPIEIMGYQLEPGMVAIVPIYLTHHREDIYPEPKKFKPERFLERQFSPYEYLPFGGGS

RRCIGSAFALFEMKLVLATILSQWELKLLPNQRISPVRRGLTMAPPANMRMVVKPKKS

WQKVSQPILTSG

 

>CYP110D4 gi|119486457| ZP_01620515 Lyngbya sp. PCC 8106

MTLPNGPQTPRVLRMMKFVARPLDYLEDYYRRYGDFIRIGKSATPLVYVNHPAAIEKIFTAGSEQFRTGN

AGGVLLFLLGDNSVLMVDGERHERQRKLLMPPFHGERLKTYNQLICEITKEVMSQVKIGQPFRVRTLMQD

ITLRVILKAVFGLTEGERYEQLRHLLSAMMESIGSPLAASLMFFPSLRQDWGEWSPWGRFLRYKQQADEM

IYAEIRERKQQRDFDGDDILTLLMSARDETGKPMNETELRDELVTLLIAGHETTASSLTWALYWTHYLPE

VKDKLCFELANLGENPHLSEIARLPYLTAVCNETLRIYPVTLTSGVRVLKKPLELGGYSFEPGTVLFPCT

YLVHQREDIYPEPKKFKPERFLQRQFSPYEFFPFGGGHRRCIGSAMATLEMKIALATILSDWQLKLPHHK

AYKPVRRGLTLSPPAQLSLVAVNRLN

 

>CYP110D5 gi|67920042| ZP_00513562 Crocosphaera watsonii WH 8501

MNLPPTLSQPRLLRLFKLIFYPLDYLEDNYQRYGDIFVAGKSETPFVYISNPQGIQTILTRDKTDFKTGG

GSGFLSTLLGDNSLLFLQGERHRRERKLLMPPFHGERLKSYANLIYSISDKVTDKLQINRSFNVRDIMQE

ITLKVILKAVFGITEGERYQRLQELLKSWLSFFDSPANAILIFFPWLRKNWGNWTPWGRFLQIKAEIQEL

IYTEIRERREQKKYEGTDILTLLMLAKDEEGKPLSDQELHDELITLLIAGHETTASALTWALYWIHFCPD

VEDKLRFHFSNLNNNTDLLDIVKLPYLDAVCKETLRIYPVLLTTFIRVLQTPLELMGYQFKPGTVFAPAI

YLVHHREDIYPNSQQFRPERFLERNFSPYEYFPFGGGSRRCIGMELAKMEMKIVLYTILSKHKLKLPSSR

PLKAVRRGLTVAPPSNFKMILSN

 

>CYP110D6 gi|126654866| ZP_01726400 Cyanothece sp. CCY0110

MVLPPSISTPRLLRLFKLIFYPLDSLENYYERYGDIFIVGQSETPFVYISNPQGIQEILTKDKTHFRTGG

GSGFLTTFLGNNSLLSLKGEKHQRERKLLTPAFHGERLQSYATLIYSISDEVSEKLEINQSFNVREIMQE

ITLQVILKAVFGIAEGKRYQKLKNLLTSWLSFFDSPINATIIFFPFLQKDWGNWTTWGRFLRIKAQIDDL

IYTEINERRQQKNYQGKDILTLLILARDEDGNPMSDQELHDELITLLIAGHETTASSLTWALYWIHYCPE

VEEKLRSHFSILDKNIDLLNIIKLPYLDAVCSETLRIYPVVVNAFIRVLETPLELMGYQFKPGTVFAPAI

YLVHHREDIYPNSKQFRPERFLERQFSPYEYLPFGGGSRRCIGMELAKMEMKIVLFTLLSKYKFKLSSSH

PLKPVRRGLTIAPPNSFKMIITQKLAYT

 

>CYP110E1    Nostoc sp. PCC 7120 Same as Anabaena

1 MKLPDSPKIP KFMQLVQWIY QPLQLMEASA KAHGDSFTLW LTNKRPIVFL SNPQAIQELF

 61 TTPLEQLDAR GTAQVLQPLL GENSLLLLSG ETHQRQRKLL TPPFHGDRMR AYGDIITNIT

121 KEVISNWQLG KPFSVRDSMQ EITLRVILQA VFGLREGERY TQLQKRLCDI LDLSGSALRS

181 TLSFLPALQI DLGRWSPWGH FLRQREAIDQ LLYAEIQDRR DHPDPSRTDI LSLMMAARDE

241 NGEAMTDVEL RDELMTLLVA GHETTASALT WALYWIHKLP QVREKLLAEL DNFGDNGDVN

301 EITRLPYLTA VCQETLRIYP IAMVTIPRIT KTNLEIGGHQ FAPGTMLVGC IYLMHRRPDL

361 YPQPQEFKPE RFLEKQYSLY EYLPFGGSNR RCVGMAFALY EMKLILATVL ANVDLALVDN

421 YPVKPTRRGV TLAPSGGKWL IATAQHQKIK NPVEV

 

>CYP110E2   Nostoc punctiforme

MSLLKLPNGPQTHPWIQMYQWLTNPLEYMEACTKRYGDIFTLKL

GQNFAHQVFISNPQAIQQIFTTDPKQLDSGESAGIKAPLLGQQSLLALDGKPHQRQRK

LLTPPFHGERMLAYGELIREITEQVSSQWQVGETFAVLPSMQAISFQVILKAVFGLED

GPRYKKLNELLIKILNPKIPLLRTVLLIFPSMRQDLGAWSPWGKYLRLRQQIDQLIYA

QIQERKAQPNLSGTDILSLMMAARDEAGEPMTDLELRDELMTLLVAGHETTATSLSWA

LYWIHHRPQVREKLLQELDNLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMSALNRLV

KSPLQIGEYNFEPGTILIPSIYLTHHREDLYPESKQFKPERFLERQFSPYEYLPFGGG

NRRCIGMAFALFEMKLVLATVLSRWQMELADSKPVRPVRKGLLFSPAGGVQMVVKGKR

LQNQPILQTSSSSV

 

>CYP110E3   Trichodesmium erythraeum

1 MIKLPGPKSP ALTQILQWTA KPIKFMEKCA REYGDTFEVK LNYPIVFISH PKAIEEIFKA

 61 NPKKFDCGSS NKLAQPLLGD YSLLLLDDIP HQRQRKLLMP PFHGKRMQAY GELICNVAQE

121 VASKWEIGQV FSMREFTAEI SLKVILQAVF GLYEGERYSK LEKLLGSLLE SLSSPLKTSM

181 LFFQFLQIDL GPWSPWGNFI KNREEIYELL CAEISERRQK LDPERSDILT MLLLARDEEG

241 EGMSDIELRD ELMTLLIAGH ETTATSLSWA FYWIHHQPEI YQKLSRELET FGDDLNPMTV

301 INLPYMNAVC SETLRIYPVV IIVSPRKTKL PITIMGQT

 

>CYP110E4 gi|37522632| NP_926009 Gloeobacter violaceus PCC 7421

MSLPPGPSSPSPFQLMQWIGCPTDYLHTTAARYGDPFTMRVGVFPPLVMFSDPRAIQQLFTAEAGTFDAG

ASNVALRPTLGANSLLLLDGERHQQQRRLLTPPFHGERMRAYGELIRQVTEEVIVRWQPGKPFLVRNAMQ

RISLAVILQAVFGLHDGTRLVRLRQALGSMLDAMSSPLSMAMLLMLPEDFGPWSPRARLQAHLGAIDELL

YAEIRERREHFDAGAGDILGLLLAARDEAGAAMGDAELRDELMTLLVAGHETTATAMAWALYWIHYLPQV

RERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVALIASPRVARHTVRILERDYEAGTRLAAGIY

LAHHRPETYPEPERFRPERFLERTFSPYEFVPFGGGSRRCIGMAFALYEMKLVIATVLLERDLRLVQPRL

LRPVRRGVTLAPPEGLYLVPTGERSASRLLSRTSTAGQ

 

>CYP110E5 gi|37522633| NP_926010 Gloeobacter violaceus PCC 7421

MSLPAGPASPPPLQLLQWIGRPTDYLERTARRYGDPFTMRLGLHSPVTGVFFSSPEAFQQLFNTEPGLFD

SGGANASSTFNLLFGTNSLILLDGERHQQQRRLLTPPFHGERMRSYGELIRTLAEQVTARWNLGTPFQAR

RSMQRISLGVILKAVFGLHDGTRYLRVCRLLGNLIDASASPLLFGLRLIFPQDAGPMSPMGQLKAQIDAI

DELLYAEIRERRERPDPRADDILSLLMAARDEAGQGMGDVELRDELMTLLVAGHETTATAMAWALYWIHR

LPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVAMVAFARVPRRPVRILDREYPAGTFLI

PNIYLAHRRPEAYPDPERFRPERFLERTFSPYEFVPFGGGSRRCIGVAFALYEMKLVLATVLSRVELRLA

DPRPRLPVRRGLTLAPPEDLHLIPTALRSGHRDLLPAC

 

>CYP110E6 gi|75908324| YP_322620 Anabaena variabilis ATCC 29413

MKLPDSPKIPRFMQLVQWIYQPLQLMEASAKAHGDCFTLWLTNKRPIVFLSNPQAIQELFTTPLEQLDAR

GTAQVLQPLLGENSLLLLSGETHQRQRKLLTPPFHGDRMRAYGDIITNITQEVISKWQLGEPFSVRDSMQ

EITLRVILQAVFGLREGERYTQLQKRLCDILDLSGSALRSTLSFLPALQIDLGSWSPWGHFLRQRAAIDQ

LLYAEIQDRRDHPDPSRTDILSLMMAARDENGEAMTDIELRDELMTLLVAGHETTASALTWALYWIHKLP

QVREKLLAELDNFGDNGDVNEITRLPYLTAVCQETLRIYPIAMVTIPRIVKTTLEIGGHQFAPGTMLVGC

IYLMHRRPDLYPQPQEFKPERFLEKQYSLYEYLPFGGSNRRCVGMAFALYEMKLVLATVLANMDLALVDN

YPVKPTRRGVTLAPSGGKWLIATGQHQKVKSPVEV

 

>CYP110E7 gi|119512554| ZP_01631632 Nodularia spumigena CCY9414

MPALQLPDGPKNHPWLQTYRWLTSPLEYMEDCAKNYGDIFTIRVGPLSTPQVFVSNPQAIQQIFSTDPKY

LDSGAAAGFKSPLLGNQSLLSLDGKPHQRQRKLLTPPFHGERMLAYGELIRDISQQVTNKWQVGETVSVL

SSMQAISFQVILKAVFGLAEGPRYEKIKEALIAILNPKKPLLRSMLLMFPSLRRDLGAWSPWGEFLRLRQ

QIDELVYAEIQERKAQLDSSRTDILSLMMATRDEAGEPMTDLELRDELMTLLVAGHETTATALSWALYWI

HHQPQVREKLLQELDTLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMLLLSRLVKSPLQIGEYQFEPGTL

LIPCVYLTHHREDLYPDSQTFKPERFLERQFSNSEFIPFGGGNRRCIGMAFALFEMKLVLATVLSNWQME

LANTQPVLPVRKGLLFGPKGGVQMVVKGRRELS

 

>CYP110F1   Nostoc punctiforme

MKILDSLTTPSLLQTLQLIAKPTKTLENYATKYGDIFTMRVMGL

KSPPIVFFSHPQAISDCFAVPAHKLDFKKATHVFKPLFGENSIVFKEARSHQQQRQLL

LPAFHGDNLKSYGQAICQIAEELTQSWTSGTNICIHKLMSKITLEIILQVVFGITHGV

RYQQLKEQLSALLEDVTKPWYSSLFFFPSLQKDLGAWSPWGIFLKRREQIDKLIYAEI

SERRWQNDAMRTDILSLLMSAHDVNGQQMTDEELRDQLVSLLLLGYETTSGVLAWIFY

LIHSHPEVKHRLMQELSTLDNLTNPEAITQLPYLTAVCQETLRIHPIALICTPRMLKE

PVEIMGHKFTSETVLVPCIHLAHRRTDTYPEPEQFRPERFLNQKFSPYEYLPFGGGYR

GCIGAAFSMYELKLVTAIILSRFELSLTDKRPAYPVRRGITIVPSGGVKMVVTKKAKF

KRQTILST

 

>CYP110G1   Trichodesmium erythraeum

1 MKQVCALKTP LWLQRFNYIT NPVSYWQKAY SSYKDAFYAQ GINFGKPLMV FYTPSAAKQI

 61 IENCQGDLTT TSFDSELTAI FGDSSFFILE GTNHKKMRKL LIPALHGKHI KTYGELICNL

121 VNNLIENLPF NQSFSALEIA QEISMQVMIK LLFGNYQQER YQKIKQLMIN MVSLFAANVF

181 GFPLFFKFLQ QDLGLVSPWG NFLQQRRKIQ QLIYQEIAER RNHPNQERTD ILSLLMTAQD

241 EKGNFLNDEE LLGQLLSLLF TGNESTAASI AWSWYEVYRN SKIKEKLLEE INNLGDSPEP

301 LSLFNLPYLS AVCNETLRKY PVTMFMIPRI VKNTTEINGY QLDKGMLVTV GTYILHHRED

361 IYDQPEEFKP ERFIEHRFSS FEFLPFGRGM RGCIGADIAL YQMKLTLATI ISHHRLELTN

421 YGQIFPKRRN TILTPIKLRI IKAC

 

>CYP110H1   Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_2802

MSQLPRGPRS RLLTTYKFLT RPFEFLTHCA ATYGDVFNVP VVSGDVVIAG GPRTVQDVMT 
APPETFLPFA TRAIAPLVGE HSLLMLSDER HRRERKLLTP PFHGDRMRAY AAAMADTAAR 
RLTEAARAPR AVAQELTQAI SLDVIIRAVF GVEEPSRTSA FARAVVAMTD ALTPALTFLP 
PLQRELGGLG PYARFRRRVG ELDALFRAQI ERARAAPGDD ILSLMVSARY DDGSRMSDQA 
IFDELRTLLF AGHETTALAL AWALDHVHRH PGVLARLRDE IDALGPEPDP ERLAALPYLD 
AVCKEALRVY PIVTESPRLL AQPFRLGEHE LLPGTGVAPC ILLVHHHPEL YPEPSRFRPE 
RFLERKFSPF EYLPFGGGHR RCIGAAFAMF EMKIVLGVAL SAWEFRLLDE RPPRPVRRNL 
TLSPSGGVPL VLRARGRSRL YAAA

 

>CYP110J1   Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_5885

MGNLPPGPKS LSLVDTIRAG FISSEPVFRR YAAEYGPTFR LRSPNGILTI TGDPEAIRAV 
YTADPDEFDV WGVQLTEPVF GTSSVVVTAG ARHRRDRRLL APPFSAGAMR GYGDAIAEIS 
LDVASRWRPG RSFSMLAATQ AIALDVIVRV VFGVRGEARV GRTREAVLGL IESLSPSFMI 
IPALRRDFAG FGPYARHKRA ARALDALLFE EIRARRAEGD ASQDILGLMM SARHDDGAGM 
SDVEIADQLR ALLFAGHETT AMSLGWAMYW LHREPAVLAR LLDELDTLGP APEADALASL 
PYLEAVCLEA LRLHPPVVDV ARVVKRPFRL KGYTIPAGEA IAASPLLLHG REDLYPSPER 
FRPSRFLDRK FTPFEFIAFG GGARRCLGAA FAMYEMKVAL GTILGRYRLR LESQAPIHHV 
RRGLTMGPSG DVAMILEGER ERARAEGRPA AVQGSPAEPA LRPAAPQPAG RCPMGFS

 

>CYP110K1 gi|126660674| ZP_01731775 Cyanothece sp. CCY0110

MTATIKAKKSNNLAFPQGIKRYGLKGILNLIFRPLPTLEAYRNRYGDIYYSPAFSSFPPFIVVSNSEGVE

ALFTADPDLFNSGTSNAAFQPLLGSQSILQLDGEPHKKRRKLLMPSFHGQRLQTYGEIITNITQSIISHW

QKEDIFSMREVTQEITLSVILQAVFGITQGNNYQSLRKQLGRYLDLFNSPLYTSTLFLPILQKNWGTWTP

WGNFIAQRDKVYELLSQEIDKRTTTKDGEDILTLLLSVIDEEGEHLTKSEVMSELMTLLFAGHETTASAL

AWAFYWIHFHPEIYHNLKDELDTIDLDTDPMEIAKLPYLSAVVSETLRIYPIALFAFSRTLTTSWEFMGY

SLDKGMSLAPCIYLVHHHPDIYPNSKQFKPERFLERQFSPYEFIPFGGSNRRCLGYALALYEMKLVLATV

LKQVNLKLVSSQPILPVRRGFTMSPQGGVKMQVI

 

>CYP110L1 gi|113954988| changed from 110H1 YP_731620 Synechococcus sp. CC9311

MLEAILRPIAYYRRCFFRNSGVVRVRMSPTLPPQQVLISDPSVIKELINEDGGRHITAPGQLNGLLSQVL

GKHSIILLAPATHRQRRKLLTPPFHGERLKAYGQLISSLADQSLIDLNVGDVFDAREQMQGITMRVILTA

VFGLHEGDAFRQLERSLASSISIRSGPLGSLLLFFPFLRRDLGRWSPGGRIKAADAAIRRLLLEQIASRR

RAVERCGEENMSADILSLLLSCKDDEGQGLSDDELHDELLTLLFAGHETTATALTWAFYWIHRNPLVLER

LMNELNGLLDHSDPEAIARLPYLSAVVNEVLRIHPVAMLTFPRRIESAITLGGYAFRSGDVVMACIQAVH

ERPDLYPKPLQFNPERFMNQTYGLHEFLAFGGGSRRCIGAALALYEMKLILAKILLNNQFELTPKSNRWN

KPRRRGFTLGPSIPVKLKMVSLRP

 

>CYP110M1 gi|119485435| changed from 110J1 ZP_01619763 Lyngbya sp. PCC 8106

MRLPDGPRLPALLQTLQIIAQPTQFLERCANQFGDCFTLRVLGFNSPPIVFFSNSEAIEAIFTTDTDKFE

LGKITHVFQPLTGSQSLIMQDGKRHQRLRQLLMPSLHSKQLPAYGQTICNLTLKATQNWSPGDFISIRDY

TSEIALEVILQVVLGLKENRRYFQLKHLIEPYLESVNKPLNSIQFFLPPLQQNLGQKSPWGKFLKQRKKI

DDLIYAEIAERRTKPLGEDVLSLLISAKDEAGQPLTDQELRDQLITLLLLGHDTTASALAWAFYWIHRYP

KIVNQLVEELNSLGENPDPMDIVQLPYLNAVCQETLRIHPIALISQPRVVKESIKIENYQFKPGTILVPC

IHLAHHREQIYPNSKQFNPNRFLEQKFSPYEYLPFGGGNRSCIGMALSLFEMKLILATILLNYQLAFNQS

HVVKPVRRGITIVPSINFRLTVLTRKQAGIASKSVNH

 

>CYP110M2 gi|56750197| changed from 110J2 YP_170898 Synechococcus elongatus PCC 6301

MLPPGPSQLALLQTLRIITQPVSFLLSCADRYGDWFTLRVLGPQSPPVVFVSDPEAILAIFSSLADQLEL

GRIADVFRPLVGNESLIMQNGDRHRQQRQLLMPALQGERLFDYTPAMTAITQAAIAQWPLGQPLDLRRQM

SQISLAVILQVVFGLTPGPRYRDLYQRLDQLLEAITDPLYSLQFFWPALQQDWGNWSPWGRFCRQREAID

ALITAEIQEGRQSQQPRQDVLELLLAARDRDGNPLSDQELRDQLMTLLLLGHETTASALTWAVFWLLRHP

DCLNRLQSELVAIGDNDRAIAKAPYLDAVCREALRLQPIALIAQPRRVASPLSLGGYDFASGTILVPCVL

TAHRRAATYPNPDQFQPNRFLERRFSNGEFLPFGGGQRSCIGMALSLIEMKMVLATLLRQCQIAEVSQRP

VRPARRGITFVPSQDFRIQVQQWHNPSAQTAIASV

 

>CYP111A1    Pseudomonas incognita

MERPDLKNPDLYTQQVPHDIFARLRREEPVYWNPESDGSGFWAV

LRHKDIIEVSRQPLLFSSAYENGGHRIFNENEVGLTNAGEAAVGVPFISLDPPVHTQY

RKVIMPALSPARLGDIEQRIRVRAEALIERIPLGEEVDLVPLLSAPLPLLTLAELLGL

DPDCWYELYNWTNAFVGEDDPEFRKSPEDMAKVLGEFMGFCQELFESRRANPGPDIAT

LLANAEINGQPVALRDFIGNLTLTLVGGNETTRNSISHTIVTLSQQPDQWDILRQRPE

LLKTATAEMVRHASPVLHMRRTAMEDTEIGGQAIAKGDKVVLWYASGNRDESVFSDAD

RFDVTRTGVQHVGFGSGQHVCVGSRLAEMQLRVVFEILSTRVKRFELCSKSRRFRSNF

LNGLKNLNVVLVPK

 

>CYP111A2    Novosphingobium aromaticivorans

MLDLKNPDTYQGGVPYAALQDLRAEGPVHWNPESDGAGFWAVLG

HDEIVAVSRQPDLFSSAFENGGHRIFNENQVGLTGAGESAIGIPFISRDPPSHTQYRK

FVMPALSPARLQGIEERIAKRVERLFAQVPLGETVNILPLLTVPLPLLTLAELLGVPA

DLWPDLHRWTDAFVGEDDPDFRQSPEAMQAVLAEFMGFATALFEDRRANPGPDIASLL

ANTEIRGEPAPLRDFIANLILALVGGNETTRNSINHTMIALAENPGQWDILRADPSLM

TAAVKEMVRFASPVIHMRRTAMRDTQLGQQAICKGDKVVIFYPAGNRDPAVFENPDRF

EITRPVRQHLAFGSGAHVCVGSRLAEMQLRLAFAEMARHVRAFEVVGEPSRVRSNFIN

GFKRLEVRLLV

 

>CYP111B1 ABS61652.1 Parvibaculum lavamentivorans DS-1

CDS  complement(33622..34875) locus_tag="Plav_0029"

49% to CYP111A1 P450 lin L23310 Pseudomonas incognita

MLRPQAKAIDLNGKPDLKDPDLYLHEQHHEAFRRLRAEEPVYWNPEADGPGFWAVTRYDDIEAVSKNPKL

FSSAKHNGGHRIFNENEIGGNDTDASMISMDPPAHAGYRRMVTPGFVPKRISNMEERIRARVTRLLDAMP

KTGEAEFISAVAAALPIEVLAELFGVPESDGPKLFEWSNATVGEDDPELRVSDEYMQKCIMEMAGYAAGL

WQQRLETPGDDLISMLAHSKIGGEAMNFPTYIGTFILLVVAGNETTRNSISGGLLALSENPGERQKLLDD

PSLIPSAVQEIVRWVSPVLHMRRTATEDTELRGQKIRKGDKVVMWYASGNRDEAQWADPYRFDVARYAAP

GVPAQIGFGVGQHFCLGSRLAELQLTILFEELLRRFPDINVSGPIRRLRSNFIYGIKEMPVSYTPEG

 

>CYP112A1    Bradyrhizobium japonicum

MSEQQPLPTLPMWRVDHIEPSPEMLALRANGPIHRVRFPSGHEG

WWVTGYDEAKAVLSDAAFRPAGMPPAAFTPDSVILGSPGWLVSHEGREHARLRAIVAP

AFSDRRVKLLVQQVEAIAAHLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDH

AFFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPDDNLLTDLLAAVD

QGKASEEEAVGLAAGMLVAGHESTVAQIEFGLHAMFRHPQQRERLVGDPSLVDKAVQE

ILRMYPPGAGWDGIMRYPRTDVTIAGEHIPAESKVLVGLPATSFDPHHFDDPEIFDIE

RQEKPHLAFSYGPHACIGVALARLELKVVFGSIFQRLPALRLAVAPEQLKLRKEIITG

GFEQFPVLW

 

>CYP112A2    Rhizobium sp. NGR234 plasmid pNGR234a

MPEQPLPTLPMWRVDHIEPSPTMLALRANGPIHNVRFPRGHEGW

WVTGYDEAKAVLSDAAFRPAGMPPAAFTPDCVILGSPGWLVSHEGGEHARLRTIVAPA

FSDRRVKLLAQQVEAIAAQLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDHA

FFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPGDNLLTDLLAAVDR

GEATEEEAIGLAAGMLVAGHESTVAQIEFGLLAMLRHPQQRERLVGNPSLVDKAVEEI

LRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPRHFEDPEIFDIGR

DAKPHLAFSYGPHYCIGMALARLELKVVFGSIFQRFPALRLAVAPEELKLRKEIITGG

FEEFPVLW

 

>CYP112A3v1  Mesorhizobium loti

1 MSEQPLPTLP MWRVDHIEPS PEMLALRANG PIHHVRFPSG HEGWWVTGYD EAKAALSDAA

 61 FRPAGMPPAA FTPDSVILGS PGWLVSHEGG EHARLRTIVA PAFSNRRVKV LAQQVEAIAA

121 QLFETLAAQP QPADLRRHLS FPLPAMVISA LMGVLYEDHA FFAGLSDEVM THQHESGPRS

181 ASRLAWEELR AYIRGKMWDK RQDPGDNLLT DLLAAVEQGN ATEEEAIGLA AGMLVAGHES

241 TVAQIEFGLL AMFRHPQQRE RLVGDPSLVD KAVEEILRMY PPGAGWDGIM RYPRTDVTIA

301 GVHIPAESKV LVGLPATSFD PRHFDDPEIF DIGRDENPHL TFSHGPHYCI GMALARLELK

361 VVVGSIFQRF PALRLAVAPE ELKLRKEIIT GGFEEFPVLW

 

>CYP112A3v2  Mesorhizobium loti

            GenEMBL AL672112 complement(85404..86606)

            Strain R7A symbiosis island

            Gene = msi071

            2 DIFFS with CYP112A3v1

 

>CYP112A4   Rhizobium etli symbiotic plasmid p42d

MSEQSLPTLPMWRVDHIEPSPEMLALRAKGPIHRVRLPSGHECW

WVTGYDEAKAVLSDAAFLPAGMPPADFTPDSVILGSPGWLVSHEGDEHARLRTIVAPA

FSNSRVKLLTQQVEAITVQLFDTLAVQPQPADLRRHLSFPLPAKVISALMGVPFEEHA

FFAGLSDEVMTHQHESGPRSASGLAWEELRAYIHGKIRGKRQDPGDNLLTDLLAAVDQ

GKATEEEAIGLAAGVLVAGHESTVAQIEFGLLAMFRHPQQRERLVRDPSLVDKAVEEI

LRMYSPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPCHFKDPEVFDIGR

DANPHLAFSYGQHNCIGAALARLELKAIFGSIFQRFPALRLAVAPEELKLRKEIITGG

FEEMPVLWCGRPPASQSSHLAAPGAHRSDQPLDR

 

>CYP113A1    Saccharopolyspora erythraea NRRL23338

MTTIDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHAD

VQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTPRTISDLEP

RIRDVTRSLLADAGESFDLVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQM

DDPTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAA

NFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQ

MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQFSFGH

GVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLAGSS

PRQSA

 

>CYP113B1    Streptomyces fradiae

MTTQTLEAEKPPEPERTANSVHPLAQPAGAGARGLLEWFARARA

EAPVFWDESRQAWQVFRYDDYLTVSTNPQLFSSDFSPVFPVPEELAILMGPGTFGGID

PPRHGPLRKLVSQAFTPRRIATLEPRIAEITRGLLDGLREKGQIDVVSDLAYPLPVIV

IAELLGIPAEDRDLFREWVDVILNNEGMEYPNLPDDFSETMGPAIKEWGDYLYRRIAL

KRETPTDDLMSGLIEAEVEGRRLTDEEIVNIVALLLTAGHISSATLLGNLFLVLDEHR

EAQAELRADRDLIPGAIEETLRYRSPFNNIFRLLKEDTDILGHPMKAGQMVVAWIASA

NRDSAHFSDPDTFDVRRQPNKHMSFGHGIHHCLGSFLARLEAKVFLELFFDEFSDYRV

EHDEVEFYEEDELTARRLPVTVTRH

 

>CYP113B2    Streptomyces caelestis

MVDSVTGPMELSKDANAKELLDWFSHNRTHHPVFWDEGRQAWQV

FRYDDYLTVSNHPEFFSSDFTEVAPTPPELEMILGPGTIGALDPPAHGPMRKLVSQAF

TPRRMAGQEQRIRVIAEELLDRVRGQKTIA

 

>CYP113B3    Streptomyces mycarofaciens

MSEAPTVPLELSKEANAQELLGLGSPSTGTHHPVFWDENWACLG

KVFRYDDYLTVSNNPQFFSSDFNEVMPTPPELEMVIGPGTIGALDPPAHGPMRKLVSQ

ALTPRRMARLGPRIRAVTQGLLDAVRGQETIDVVGDLSYALPVIVIAELLGIPSGDRD

VFRGWVDTLLTNEGLGYPSLPDNFSETIAPALKEMTDYLLHQIHAKREAPVDDLICGL

VQAEQDGRKLTDVEIVNIVALLLTAGHVSSSTLLSNLSLVLEENPQALADLRADRELV

TGAVEETLRYRSPFNNIFRFLKEDTDILGPEMKKGQMVIAWSQSANRDPEHFPEPDTF

DIRRSSSSRHMAFGIGIHHCLGAFLARQEGKVVLELML

 

>CYP113C1   Streptomyces virginiae

MAQQTPPAPPSMADGGKAMLAWLRTMRDEHPVHEDQYGVFHVYR

HSDVLAVTSDPAVFSSDLSRLRPDSSALSEEILSVIDPPLHRKLRSLVSQAFTLRTVA

DLEPRVTELAGRLLEKVEGSEFDLVGDFAYPLPVIVIAELLGVPAEDRELFRGWSDRM

LSMQVDDPLEIQFGDEAGEDYERLVKEPLKEMHAYLQRHVDARRETPGDDLLSRLVTA

EIAGERLTDRQIVEFGALLLMAGHVSTSMLLGNTVLCLEENPETAAALRADRALISGV

IEEVLRMRPPITVAARVTTGEVVVGGVTIPKDRMVMASLLSANHDERHIQDPEVFDPR

RSPNPQLAFGHGIHYCLGGPLARLEGRVALEMLLDRFEDIRVTPGAPYDFHREGLFVP

ARSPLTVRRG

 

>CYP113D1    Saccharopolyspora erythraea NRRL23338

MSIPADTWGIPASQFWLRGRRPERTVDYDAATGMWNVYGYPEIQHVLSDPRTFSSDTTRL

MPAKVAERTSALSEGSLLQMDPPEHTKLRKLVSHAFTPKVVADLAPRIADLANELLDDVG

DRMEMVEDLAYPLPVIVIAELLGVPGSDRHLFKKWVDALLQRDQQFSLVDESDEQVQQVE

EAIAQVKHLTDYLGEHAAERRRAPREDLLTKLVQAEVDGHRLSDTEVVNFANILLLAGHI

TTTMLLGNTVLCLDTHPRQRDAVRADRSLVPSAIEESLRFFSPFAVLGRVTQREVEVGGQ

TIPQDQMLMLWIAAANRDPRQFADPDVFDVTRDPNPQIAFGRGIHFCVGAPLARLEGKVA

LNILLDRFPHLRTDPDEGPTFLPAPTTTGVRKLPLLLTPSA

 

>CYP113E1   Salinispora tropica (marine actinomycete)

MATVPRLTFADGGVSVLPWFRQMRDDQPVWYDQGTGSWNVFRYADIAQILTDPATFSSDP

GRTMPPELVEEAEGSLVAVDPPRHGRLRALISTAFTPRLVEQLAPRVRSIAERLLDRTFV

DRGPEGEFDAIGDVAYLLPVYVIGELLGLPETDREYLVRTADEFYAISADDPFDGTYMAS

MQSTLDGLGTYMLDQAERRRARPGDDLMSALAHAEIDGEQLNDREIRNFAVLLLTAGHIT

TTALLGNTLLALGERRDVMLRWRHGQVDTADVLEEVLRHRTPFTEVYRFTTTEVTIGNQV

VPGDQLLRLWIASGNRDERQFADPDTFVLGRDSRHLGFGLGIHYCLGASLARMESSVVLE

VLAERTTTLAPAVQGLSYYDAPGIFCLRSLPVSYRRS

 

>CYP113F1 Streptomyces sp. Tu6071

          ABB69748

          PlaO3

  1 MTASEEGTRL ADQSADAATM LAWFRRMRES EPVSHDEEAG VWHVFRHADV ERVLADPGTF

 61 SSDFSSFMPA QEDVDRFIKG NLLRKDPPQH RKLRTLVSKA FTPGVVARLA PRIEVIADEL

121 LDAKAGADQL ELVADLASPL PVTVIAELLG IPAEDRPMFG RWADSLVAPE SQTSFIPNED

181 RTKAMAVVMR EMNAYCLEHI RRRRAAPSQD LVSKLVAAEV DGQRLDDDEI IGFVGLLLLA

241 GHITTTALLT NVILCLDEFP DIAAALRADP SALPGAIEEV LRFRTPLAPS MRRTTREVRV

301 GEHTVPAGRI LLAWLASANR DERQFTAPDT FDIHRAPNPH LSLGHGIHFC LGAPLARLEV

361 RIAVEKMLGR WSGITVADGV ECHDARGIVG AKKLPLRLRW A

 

>CYP113F2 Frankia sp. EAN1pec

MSQLTTRPNAVRRSLPDLLRWLDELRRRGQVHRDDRQRCWHVLGHPEAGAVLADHRSFTSDLRGLLPRPE

DMPEYNLQEGSFQEDMELFQRGNFVRLDPPEHHRLRGLASRAFTSRTVAGLAPRIAEVTTELLDATGGRT

RLELIDDLAYPLPVIVIAELLGLPAADRPMFRGWADALFDREVADPDQPLTELAAANTRAAVPVLREMNA

YLLDRIRACRAHPGDDLTGRLVQVEVDGQRLADEEIVGFVGLLLLAGHITTTATLGNAALALDEHPGAAA

ELRAEPELLPATIEEVLRLRTPFPRLVRRAVADTRVGDEVIPAGAVVTVWLTAANRDERVFAEPDRFDPR

RAPNPHIAFGQGIHFCLGAPLARLEARTALGILLDRYSDIAVAADVPVEHRDPWAMVSVNSLPLDVRPR

 

>CYP113G1 SBI_3232 Streptomyces bingchengensis

47% to CYP113C1 Streptomyces virginiae  
MSEQAISLTPPSAADGGATLFGWLRRMREESPVVQDNNGSWYVFRHADVQ

HVLTEYADFSSDPTPISPKAAEIAKGDLAQIDPPEHHGLRRQISRVFTPR

MVAELEPRIEEIGRLLLDEAGDAGELDLVRQLTHPLPVIVIAEMLGVPAE

DRPVFRHWADRIIAAKIAGIDDPETYERLRSAIEEMDFYLEGQLDERRSR

PGDDLLSKMVTAEVDGDPISGAEAVNFARLLLVAGHITTTMMLSSSILCF

DEYPEAAREVREDRSLLPAAIEEVMRYRPPFTITGRYTTRDVELSGVTIP

ERSVVIPWLASANRDERRFMDPDVFDIHRSPNPHVAFGKGIHFCIGAPLA

RLEGKVALNLLFDRYSDVRIDRDASLEFYEHNFFGVKSLPVSVKHA

 

>CYP114A1    Bradyrhizobium japonicum

MLSRHADIFWAFKATGDAFRGPAPGELARYFSRAATSPSLNLLA

STLAMKDPPTHTRLRRLISRDFTMGQIDNLRPSIARIVAARLDGITPALERGEAVDLH

REFALALPMLVFAELFGMPQDDMFELAAGIGTILEGLGPHASDPQLAAADAASARVQA

YFGDLIQRKRTDPRRDIVSMLVGAHDDDADTLSDAELISMLWGMLLGGFVTTAASIDH

AVLAMLAYPEQRHWLQADAARVRAFVEEVLRCDAPAMFSSIPRIAQRDIELGGVVIPK

NADVRVLIASGNRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQL

ARVQLAESLPRIQARFPTLAFAGQPTREPSAFLRTFRTLPVRLHAQGS

 

>CYP114A2    Rhizobium sp. NGR234 plasmid pNGR234.

MDMQETTTACADAFAELASPACIDDPYPFMRWLREHDPVHRAAS

GLFLLSRHADICWALKATGDAFRGPAPGELARYFPRAATSLSLNLLASTLAMKEPPTH

TRLRRLISRDFTMREIDNLRPSIARFVAARLDGMAPALERGEAVDLHRQFALALPMLV

FAELFGMPQDDMFGLAAGIGAILEGLSPHASDPQLAAADAASARMKAYFGDLIQRKCI

DPRHDIVATLVGAHDDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPDQ

RHWLQGDAAGVEAFVEEVLRCDAPAMFSSIPRIAQSDIELSGVVIPKNADVRVLIAAG

NRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQLARVQLAESLPR

IQARFPTLTVAEQPTREPSAFLRTFRALPVRLHAQGDSPRLTSAFLNGQRGVEGGASF

EHGDGERRSATDRRAQP

 

>CYP114A3v1  Mesorhizobium loti

1 MDVQETTAAC RDAFAELASP ACIQDPYTFM RWLREHDPVH RAASGLFLLS RHADIYWALK

 61 ATGDVFRGPA PGELARYFPR AETSLSLNLL ASTLAMKEPP THTRLRRLIS RDFTIRQIDN

121 LRPSIARIVA ARLDGMAPAL ERGEAVDLHW EFALAVPILV FAELFGMPQD DMFGLAAGIG

181 AILEGLSPHA SDPQLAEADA ASARVQAYFG DLIQRKRTDP RNDIVSMVVG AHDDDADTLS

241 DAELISMLWG MLLGGFATTA ATIDHAVLAM LAYPEQRHWL QGDAVGVKAF VEEVLRCDAP

301 AMFSSIPRIA QRDIELGGVV IPKNADVRVL IAAGNRDPDA FSDPDRFDPA RFYGTTPGMS

361 TDGKIMLSFG HGIHFCLGAQ LARVQLAESL PRIEARFPTL ALAEQPTREP SAFLRTFRAL

421 PVRLHAQGG

 

>CYP114A3v2  Mesorhizobium loti

            GenEMBL AL672112 complement(84020..85309)

            Strain R7A symbiosis island

            Gene = msi070

            10 DIFFS with CYP114A3v1

 

>CYP114A4   Rhizobium etli symbiotic plasmid p42d

MDVQDTTAACHDAFAELASPACIQDPYPFMRWLREHDPVHRAAS

GLFLLSRHADIYWAFKATGDAFRGPAPSELARYFPRAASSLSLNLLASTLAMKEPPTH

TRLRRLISRDFTVGQIDNLRPSIARIVAARLDGMAPALERGEAVDLHREFALALPMLV

FAELFGMPQDDVFELSAIVSAILEGLSPHASDPQLAAADVASARVKAYFGDLILRKRA

DPRRDIVSTLVGAHTDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPEE

RHWLQGDAAGVEAFVEEVLRCEAPAMFSSIPRIAQRDIELHGVVIPKDADVRVLIAAG

NRDPDAFADPDRFDPVRFYGTRPGMSSDGKIMLSFGHGIHFCLGAQLARVQLAESLPQ

IQARFPTLALAEQPTREPSAFLRTFRALPVRLHAQAAAEVRVVVDQDLCGTTGQCVLT

LPGTFRQREPDGVAEVCMATVPQALHAAVRLAASQCPVAAIRVIESEAGDDHCTNPGP

TPSPADAERHAAKDLRNPGEHDGTI

 

>CYP115A1P   Bradyrhizobium japonicum

1 MADTSGARSN LLHQSVRSIY

   GDADRFDVTR RHNPHLSFGQ GPHFCLGAAL ARLELGCAFP

61 ALFVRLEHLA LTIAAEDVVY MPSYVIRCPQ RLPVTFRPSI A

 

>CYP115A2v1  Mesorhizobium loti

1 MPAAPTQLDR LSSAILRQGG MARVSLPGDV VTWAAARHQT LRQMLSDQRF NKDWRQWRAL

 61 QDGEIPEDHP LIGICKVDNM TTAHGADHRR LRGLLSSSFA PSRIALLAPR VEQCVDRLLA

121 EMAQRGGSAD LMSEFAAPLP TNVIAELFGL PDEQREEIVA LTYSLASTSA TAEEVRQTRQ

181 RIPEFFRRLI ALKRGQLGDD LASALIVARD KGELVSDTEL IDMLFMVLSA GFVTTAGVIG

241 NGVLALLTHP QQLHLVRSGQ VPWSQAIEEI LRWGTSAANL PFRYATQDVE IDGCLVRRGD

301 AVLMAFHAAN RDEKAFGPGA NRFDVTRRHN PHLSFGEGPH SCLGAALARL ELRCAFPPLF

361 GRLEDLALTI AAEDVVYMPS YVIRCPQRLP VSFRPSVA

 

>CYP115A2v2  Mesorhizobium loti

            GenEMBL AL672113 41375..42607

            Strain R7A symbiosis island

            Gene = msi159

            10 DIFFS with CYP115A2v1

 

>CYP115A3P   Rhizobium etli symbiotic plasmid p42d

ANSYGRPTYGDTDMFDFNRLQNPHLPLGQGPHLCLGAALARLELGSVFPPPFVRPEDLALAIAAE

 

>CYP116A1    Rhodococcus erythropolis

MTVDHAPEGVKSPTGCPVSGMAADFDPFRGAYQVDPSSSLRQAR

KDEPVFFSPLLDYWVVTRYEDIKQIFKTPSVFSPSITVDQITPISDEALQILGSYQFA

AGRMLVNEDEPIHTERRRLLMQPFEADNVATLEPKIREVVNTYLDRVIKDGRADLIGD

LLYEVPCIVALIFLGVPDEDIETCRQYGMQQTLFTWGHPTGDEQTRVATGMGKFWEFA

GGLVDKLKADPNAKGWIPHAIEMQRQHPDLFDDNYLQNIMFGGVFAAHETTTNATGNA

FRTLLENRSSWDEICADPTLIPKAIEECLRYSGSVVAWRRKAVVDTTVGEVDIPAGGR

LLIVMASANRDDSMFPEPDDFDIHRGNAQRHLTFGIGSHTCLGATLARLEMKVFLEEV

SRRLPHMSLVAGQEFSYLPNTSFRGPEHVLVEWDPQQNPVPADRP"

 

>CYP116A2    Saccharopolyspora erythraea NRRL23338

VEELQVDATRVGAGCPISRIAEEFDPFGEAYQQDPAGVLKAAREREPVFYSPELDHWVVT

RYADIKEIFRDTRRFSASNALDPITPLGAKARERLAEYDFAPGPVLVNEDEPLHMRRRRA

LAGPLAADEVAKLEGRIRDLVTRYVDGFAGRGRADLVDDLLWEVPAIVGLLVCGVPDEDI

DRARHYTIKMGSFTWGRPTEEHQVEIADQVGQWWSLSGRLVERLKREGGEGWVPTAIEVH

REDPELVNDNHLQNMMMSGLVAAHETTTNATANALRHLLSNRSSWEALCADPSAIPNAVE

ECLRFSSSVLCWRRKALVDVPVGGVTIPAGARVLLVIGSGNHDDDVFGDPGELDIARSNA

KRHLTFGIGSHACIGAPLARLEMRIILEELTRRLPGMRLVEGQDFGYLRNASFHGPRHLL

VEWEPAGA

 

>CYP116B1    Ralstonia metallidurans

MPQTNAPASSGSCPIDHSALRAPNGCPISHQAAAFDPFEDGYQQ

DPPEYVRWSRAQEPVFYSPKLGYWVVTRYDDIKAIFRDNITFSPSIALEKITPTGEAA

NAVLASYGYAMNRTLVNEDEPAHMPRRRALMEPFTPAELAHHEPMVRKLTREYVDRFI

DTGRADLVDEMLWEVPLTVALHFLGVPEEDMDLLRQYSIAHTVNTWGRPKPEEQVAVA

HAVGNFWQLAGRILDKMREDPSGPGWMQYGLRKQRELPEVVTDSYLHSMMMAGIVAAH

ETTANASANAIKLLLQHPDVWREICEDPALIPNAVEECLRHNGSVAAWRRLVTRDTEV

GGMSLAAGSKLLIVTSSANHDEHHFADADLFDIHRDNASDQLTFGYGSHQCMGKNLAR

MEMQIFLEELTSRLPHMRLAGQRFTYVPNTSFRGPEHLWVEWDPARNPERTDPTVLAP

RDAVRIGEPTGGTTGRTLIVERVETAAQGVSRIRLVSPDGRALPRWSPGSHIDIECGH

TGISRQYSLCGDPADTSAFEIAVLREPESRGGSAWIHASLRAGDKLKVRGPRNHFRLD

ETCRRAIFIAGGIGVTPVSAMARRAKELGVDYTFHYCGRSRASMAMIDELRALHGDRV

RIHAADEGQRADLAQVLGAPDANTQIYACGPARMIEALEALCATWPEDSLRVEHFSSK

LGTLDPSREQPFAVELKDSGLTLEVPPDQTLLATLRAANIDVQSDCEEGLCGSCEVRV

LAGEIDHRDVVLTRGERDANNRMMACCSRAAKGGKIVLGL

 

>CYP116B2   Rhodococcus sp. NCIMB 9784

MSASVPASAPACPVDHAALAGGCPVSANAAAFDPFGSAYQTDPA

ESLRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNILFSPAIALEKITPVSAEATAT

LARYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESG

KADLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAV

GRFWQYAGTVLEKMRQDPSGHGWMPYGIRKQREMPDVVTDSYLHSMMMAGIVAAHETT

ANASANAFKLLLENRAVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATADTRIGDV

DIPAGAKLLVVNASANHDERHFERPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEM

QIFLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLHRHQ

PVTIGEPAARAVSRTVTVERLDRIADDVLRLVLRDAGGKTLPTWTPGAHIDLDLGALS

RQYSLCGAPDAPSYEIAVHLDPESRGGSRYIHEQLEVGSPLRMRGPRNHFALDPGAEH

YVFVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSE

EGTRIDLAALLAEPAPGVQIYACGPGRLLAGLEDASRNWPDGALHVEHFTSSLAALDP

DVEHAFDLELRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVAVLDGEVD

HRDTVLTKAERAANRQMMTCCSRACGDRLALRL

 

>CYP116B3    Rhodococcus ruber

MSASVPASACPVDHAALAGGCPVSTNAAAFDPFGPAYQADPAES

LRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNLVFSPAIALEKITPVSEEATATLA

RYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESGKA

DLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAVGR

FWQYAGTVLEKMRQDPSGHGWMPYGIRMQQQMPDVVTDSYLHSMMMAGIVAAHETTAN

ASANAFKLLLENRPVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATTDTRIGDVDI

PAGAKLLVVNASANHDERHFDRPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEMQI

FLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLQRQHPV

TIGEPSTRSVSRTVTVERLDRIVDDVLRVVLRAPAGNALPAWTPGAHIDVDLGALSRQ

YSLCGAPDAPTYEIAVLLDPESRGGSRYVHEQLRVGGSLRIRGPRNHFALDPDAEHYV

FVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSAEG

TRVDLAALLATPVSGTQIYACGPGRLLAGLEDASRHWPDGALHVEHFTSSLTALDPDV

EHAFDLDLRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVTVLEGEVDHR

DTVLTKAERAANRQMMTCCSRACGDRLTLRL

 

>CYP116C1    Rhodococcus sp. RHA1 Rha08932

MTETTPAPNAEDIVAGKCPVSHFAAEFNPFDEEYQQDPYPVFKSVREQEPVFYSPEIDYWIVSRYEDIIEIFKDTESYSASEAGVMITPPCPAAMDVLAEANFVPSTMLVDEDAPLHPKRRRVFRKGLNDNKVAELEPYTRRFVSECLDTIVKNGRADMVGDMTFSVPALTAFILMGVPEAEVERVRGYAARFALWLWGRPTDEQQVALAGDYAAYLQYAREHVDKLAENPGEDYMSNVIKAWQKDGNDEVWDKTYLASIMQSHLYASHETTTNAAASGIKSLLENRDQWDAICADPSLIPGAVHEILRYQSSVPTWRRITTRPVRLGGYDLPAGSRVMMLTGSANHDDAKFEDGESFDITRENADEHLAFGWGVHLCLGQGLARMEMRVMLEETTKRLPHLRLVEDQEWTYSPNTSFRGPDHVRVEWDASQNPLPEDRP

 

>CYP116C2    Rhodococcus sp. RHA1 Rha10704

MTETSAEPHRSQGAGKCPVSHIAAEFNPFADDYLQDPYAVFTRARAEEPVFFSPSLGYWVVSRHEDVRQVFQDPAFSASISITPLKELCPAAVDELVKAEMVMGPSLVNEDPPLHTKRRRLIQKAMISPARIEAVTPRIRALTTSYIDGFVRRGHADLVADFAWEIPALVAFALMGVPDEDVERAKEFAGRLALFTWGYPSEEEQRKLAAGMGQYWIYAKEHVKRRLEDPTDDYISNLIAAWRKPGNEDLFDENYLVTTMMNFLFAGHETTTNATANGLRALLEHRDQWAALCADPSLVPGAVEEILRFSSSVVAWRREATEDTHIGDVPIPAQAKVLVLTGSANHDEEVFPEPERFDITRTNADEHLAFGFGRHLCLGAPLARIEMGIFLEELTRRLPHMQLAEGQTFTYSPNTSFRGPDHLFVGWDPSQNPVPEDRP

 

>CYP116D1    Saccharopolyspora erythraea NRRL23338

MHERFDPLATDYLADPFPILAAIREETPVFYSSELDMWPVTRHEDIKRIFTDYETFSGAI

TQTPVYPLAEEAKDILAAGFHTTPTVSNCDPPKHTRVRAHNVKAFSARRIAVLEPTIRAY

VTEMIDRILHQDRFDIVQEVTFPLPATIVFNLIGFPESDMEMLKGLAINRMAFTWGRSTE

AEQVRIAKNQVDYWQYCTEFVASRLAEPKDDFTSDLIRTHLADPDELSVDEITNVVHALS

FAGHETTTNVSSSMIQRLLTHREQWEELCADPALIPKAIEEGLRFDPSLFTWRRITTKPV

SIGGVEVPAGAKLLLLVGSANHDPAKFPDPEAFNIHRSGAQAHLTFGRGIHSCFGAPLAR

LEMQIMLEELTARMPGLRLVEDQDVQYHVNACFRGPVELWLDNSAHR

 

>CYP117A1    Bradyrhizobium japonicum

MFGGTLVAQDGIAHRQARDAIQAALLPKGLTLAGIGELFAPVIR

ARVQRWRERGDVTILRETGDLMLKLIFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDL

PGLPLRRGRAARDWIDARLREFVRAAREHASRTGLINDMVSAFDRSDDALSDDVLVAN

IRLLLLGGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEA

LFRETLRVHPATPLLVRRALRELRIGQQRIPTGTDLCIPLLHFSTSALLHEAPDQFRL

ARWLQRTEPIRPVDMLQFGTGPHFCMGYHLVWLELVQFCIALALTMHEAGVRPRLLSG

VEKGRRYYPTAHPSMTIRIGFS

 

>CYP117A2    Rhizobium sp. NGR234 plasmid pNGR234a

MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRR

AERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDG

GAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL

IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRD

ARAHAARTGLINDMVSAFDRSDDALSDDLLVANIRLLLLAGHDTTASTMAWMVIELAR

QPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPATTLLPRRALQELQL

GQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVC

IGYHLVWLELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS

 

>CYP117A3    Mesorhizobium loti

1 MDMLLNPLDR RHRLRDDIPV VPGAFPLVGH LPAIVCDLPR LLRRAERTLG SHFWLDFGPA

 61 GHLMTCVDPD AFALLRHKDV SSALIEEIAP ELLGGTLVAQ DGGAHRQARD AIKAAFLPKG

121 LTQAGIGNLF APVIQARVQA WRDRGDVTIL RETGDLMLKL IFSLMGIPAQ DLPGWHRKYR

181 QLLQLIVAPP VDLPGLPLRR GRAARDWIDA QLRQFVRDAR AHAARTGLIN DMVSSFDRGD

241 DALSDDVLVA NIRLLLLAGH DTTASTMAWM VIELARQPGL WDALVEEAQR VGAVPTRHAD

301 LAQCPVAEAL FRETLRVHPA TTLLPRRALQ ELQLGQRRIP AGTPLCIPLL HFSTSALLHE

361 APDQFRLARW LQRTEPIRPV DMLQFGTGPH VCIGYHLVWL EMVQFCIALA LTMHKAGVRP

421 RLLSAVEKGR RYFPTAHPSM KIRIGFS

 

>CYP117A3v2  Mesorhizobium loti

            GenEMBL AL672112 complement(81551..82888)

            Strain R7A symbiosis island

            Gene = msi068

            2 DIFFS with CYP117A3v1

 

>CYP117A4   Rhizobium etli symbiotic plasmid p42d

MDMLLNPLNRWRRLRDDIPVMPGAFPLVGHLPAIVCDLPRLLRR

AERTLGSHFWLDFGPAGHLMTCLDPDALALLRHKEVSSALIEEMAPDILGGTLVTLDG

SAHRQARDGIKAAFLPRGLTEAGIGELFEPIIRAQVKAWRDRGEVAILPDTRNLMLKL

TFSLMGIPAQDLSEWHRKYRQLLQLMVAPPIDLPGMPLRRGRAARDWIDAQSRQFIRD

ARARAARTGLINDMVSAFDCSDGALSDDVLVANIRLLLLAGHETSASTIAWMVIELAQ

HPELWDALVEEAQRVGAVPTGHEDLAQCPVAEALFRETLRMHPASSLVPRRAMQELQL

GQRRIPSGTHLCIPLLHFSTSPLLHEAPDQFRLGRWLQRTEPIRPVDMLQFGAGPHVC

MGYHLVWLELVQFSIALALTMQEAGVRPRLMSGVEKGRRYYPTAHPSMTVRIGFS

 

>CYP117B1   Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_5081

MTTALPASFA DLPLLQGRNP LARRIETRHG FPILPGRFPV VGHMPAIAVD ELGLLREGQR 
RFGSLFFWAP GVDAWQLIYA SNEAFSLFKS KAVDSSYLTE GGVGHLFGQT LMAHDGASHR 
RLRTAMNGPF SPKGLDAAEV GAIVATSVER KVRSWLGRRD VQLLRETREL ALEVMFKITG 
VEDDELPEWR HYYEDLMLVI LSLPFDVPGS PRRRGLRARA WLDERIGRIL AGVRARGDAK 
GLLPALLTAR DEQGEPLSEQ DLVGNLRLLL LAGHETSASV MAWCVAHLAE SPAVWRALRE 
EASSAPDLPR SPADLRRFPF AEAVFREALR LHPPVPHDAR RAVADFELDG RAVPAGTHVA 
IPLVLLSRDP ELYPDPDSYR PERWLGRKEA LSPLEIAQFG GGAHFCLGYH LAWMEIVQFL 
VALGRELPAS GPRLQGGFPA SRYLPVLRPS GGTRVRFDG

 

>CYP118P1/CYP102 PSEUDOGENE Mycobacterium leprae

RLGSGIVEQRISVLSIIALADPXXXXXXXDETVWENI

XXXXXXRLLMGDELFTXXXXESNWGKAHN

TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH

DIAAQTRREIYQNRSDRGIANVSY

FGDVVKLRCLRRVVDATLRLWS

VPCYLRQARRD

TTLGNGTSLFHKGQWVIVLLTAPMPG

WGPDANEFNPDRVLPEICRKLPYTYIL

FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG

YCLSISEAFTLKTVGL

 

>CYP119A1   Sulfolobus solfataricus (an archaebacterium)

MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLT

GYHERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRET

TRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGE

IFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLI

SNSVIDFTRFNLWQRIREENLYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGE

YVRVWIASANRDEEVFHDGEKFIPDRNPNPHLSFGSGIHLCLGAPLARLEARIAIEEF

SKRFRHIEILDTEKVPNEVLNGYKRLVVRLKSNE

 

>CYP119A2   Sulfolobus tokodaii

           GenPept BAB66184                

           64% to CYP119A1 U51337 Sulfolobus solfataricus

  1 MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL EMLRSGKVFF

 61 DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV TVKLLSELDE EFDVIESFAI

121 PLPILVISKM LGINPDVKKV KDWSDLVALR LGRADEIFSI GRKYLELISF SKKELDSRKG

181 KEIVDLTGKI ANSNLSELEK EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA

241 LKAVEEALRF SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP

301 DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID NEVLNGYRKL

361 VVRVERA

 

>CYP120A1    Synechocystis sp. (strain PCC6803) Cyanobacterium

MITSPTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGKKRQQQFG

PIFKTRLFGKNVIFISGALANRFLFTKEQETFQATWPLSTRILLGPNALATQMGEIHR

SRRKILYQAFLPRTLDSYLPKMDGIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFM

GEKVSQNPQLFPWFETYIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQP

PSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDI

RERVRQEQNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGF

HFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECL

GKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKLHSLM

 

>CYP120A2   Trichodesmium erythraeum

MTANYLEKWVEMGTLTWYPEIRNYTFDIASLLFMGSDESSQTKL

VSLFEEWVKGLFSIPLSLPWTRFGKSLRCRQKLLQHIEEIILQRQQQQNLGEDALGIL

LQAQDKEVNGLSLDELKDQILLLLFAGHETLTSAIASFCLLTSQHLDVLTRLRQEQKQ

FSAIEPLTLENLKRMTYLDMVLKEVLRLIPPVGGGFRQVTQDCEFCGYSIPKGWLVQY

QIAKTHQDETLYPDDKNFDPERFAPENAVDKQKVFGYVPFGGGMRECLGKEFARLEMK

IFAVMLLRGYEWELLPEQDLSVVAAPTPYPRDGLKVKFRKVE

 

>CYP120A3 gi|126659238|ref|ZP_01730375.1| cytochrome P450 [Cyanothece sp. CCY0110]

54% to CYP120A1

MLIFFFYNKSKLIYNFDQKMTNIESQKSVSLPPGETGLPFIGETLSFLFDPDFAKKKKSKYGQIYKTNIF

GNDTVTMIGAEANQFLFRNENKYVVSTWPKSTRVLLGKLSLAVKDGNFHTSRRKLLAQAFQPRALNSYIP

KMTEITQQYVEKWLQTKELTWYPELRKYTFDVACSLLISIDNASQTKLASDFETWCQGLFTLPINLPWTN

FGKALKCRAKLLQEIETIIINRQQQPKHQNDALGILLEAKDEEGNSLTIEELKDQILLLLFAGHETLTSS

LSSFVLLMAQHPNILEKVRTEQENLNITEDITSEKLKEMTYLEEVLKEVLRFIPPVGGGFRKVIEEFEFQ

GYRIPKDWTVQYQIAQTHKESDIFPDYQTFDPERFSPENMADKQKNFGYIPFGGGLRECLGKEFARLEMK

IFASVLVHNCHWQLLPDQDLEMITIPSPRPRDGLKVKITEV

 

>CYP120A4 gi|119485417|ref|ZP_01619745.1| cytochrome P450 [Lyngbya sp. PCC 8106]

53% to CYP120A1

MTTSEKKQSYPTPPGSLGLPLIGETLSFLRDRDFATKRHQKYGSVFKTNIFGNPTIMMIGTEANQFIFTN

EKKYFENSWPPSTTALLGPASLTIQTGDIHKSRRKLLAQAFQPRVLAGYVPTMEIMTRRYLQKWEQQKTF

AWYPELRKYTFDVACKLFVGDEKASETEMGEWFETWCQGLFTLPLRLPGTKFNKALNCRKKLLNQIETII

RQRQQQAEPGEDALGLLLQAKDEDGNSLSVEELKDQILTLLFAGHETLTSSVTAFCFLLAQHPDVLAKAR

LEQQQIQLTEPLSFEQLKLMSYLDQVLKEVLRFIPPVGGAFREVIETCEFNGYTFPKGWTVLYQIGKTHQ

DNSIYNQPEKFDPDRFSPERTEEKPYGYIPFGGGMRECLGKEFAKLEMKVLATMLLREYEWELLPNQNLE

MTVSPTPHPKDELLVNFKRLSEVH

 

>CYP120A5 gi|119509406|ref|ZP_01628555.1| cytochrome P450 [Nodularia spumigena CCY9414]

53% to CYP120A1

METTNSQTQNKLPLPPGNLGLPLIGETISFLRDPEFAEQRYQQYGPIFKTHLFGQPTIMMIGAEANRFLF

SNENQNFTISWPDSTKTLLGPASLALQTGGTHQKRRKLLSQAFQPRALAGYTSKMEEITHNYLHKWQRMG

TFKWYPELRNYTFDVACKLLIGTDAASDSHFGELFEEWCAGLFTIPINLPWTKFGRALRCRQQLLVKIEE

IILQRQQQPHSDADALGLLLQAEDEDGNRLSLAELKDQVLLLLFAGHETLTSAIASFCLQLAQHPEVLAQ

ALAEQQQLAIEESLTLEHLKQMQYLDQVLKEVLRTIPPVGGGFRRVIQSSEFNGYQIPEGWSVLYQIGKT

HQDSSTYTEPESFDPQRFAPERVEDKQKPFGYVPFGGGVRECLGKEFAKLEMKLFAALLIREYHWELVPG

QNLDLIMVPTPHPRDDLQVNFSTQRGAEGSAKVRGVLDLGGEVAM

 

>CYP120A6 ORF00071 [Synechococcus sp.PCC7002]

53% to CYP120A1

MTSPSELPLPPGKFGLPVIGETIEFFTDRNFQKKRLEKYGDVFKTSIFTKPTVVMVGAEA

NEVLFRNENKYVKATWPKSTRILLGADSLATQEGGIHSSRRRIIFQAFQPRALESYIPTI

EKITQRYLTQWEQKQEFAWYDELRKYTFDVASTLFIGKDGGAETPLANLFEEWVKGLFSL

PINLPWTAFGKAMKCRRKLLRELEMIIGDRLKTYDANAEPTDALDLLIRAKDEDGNSLSI

DELKDQILLLLFAGHETLTSSLVSFGLLVGQHRDVFEKIRAEQDALDIGNGLDMAVLQQM

TYLDQVFKEVLRLVPPVGGGFREVINTFEYKNFQIPQGWAVQYQIAQTHKDEALYPDHEK

FDPERFSPERLADKQKKFGFIPFGGGMRECIGKEFARLEAKILASMLARDYDWELLPDQD

LSMQVIPTPLPKDGLQIRFYRRQESSSTTA

 

>CYP120B1   Nostoc punctiforme

MKTNQIPPGSFGLPVLGETLSFVFDRDFAKKRYHQYGPIFKTHL

LGRPTVVMAGPEALEFVLSSHIENFSWREGWPDNFKTLLGESLFLQDGEEHRRNRRLM

MPALHGPALASYFSTMEDITRSYLQKWEKKQEFTWFQEFKQLTFDIASQLFLGTRPGP

ECVRLSQLFTTLTNGLLAINPLPLPFTTFGKAIAARNEILEHLTQVVRERQQNPTQDT

ISLLIKAKDEDGNSLSEKEIIAQAVLLLFAGHETTTSMLTWLCTELACHPEVLEKARV

EQLQLASQGDLDLEQLGKMPYLEQVLWEVERLHQPVGGGFRGVIKDFELNGYHVPTGW

QLYYSIGVTHQIEEIYSEPELFDPDRFSPQRQEHKKYPFSLVGFGGGPRICIGIAFAK

MEMKIVAAHLLRSYHWEILPNQSLEVVAVPTNRPKDGLRVRFQPR

 

>CYP120C1   Nostoc punctiforme

MQQLKSAEEIPGSYGLPILGETLEIFRDSELYLWRRFQQYGSVF

KTSVLGRKRAYLIGPSANRLVLVEQAENMSSRIGWYFLESTFGNNILLQDGEEHRLTR

RLMYPAFHGKAIATYFDTIQNIVQDFLKDWGERGTISLNSSFRQLTLMIATRLFLGSQ

NKSEVEQTSQWFTQLLDSSMAIFKWNVPFTLYGRGQNARGKLVAFLREAIAQRIEQGN

LEESKDVLGLLLAAVDEDGNKLSETQVINEALLLLFAGHETTASLLTWVIFELGNHPE

WRERLRQEQLAVVGNNPLSLSHLKQFPQLTNVLKEAERLYPPVYAYNRGVLKDIEYGG

YRIPAGWFVTISPMLTHRLPELYTEPDRFDPDRFAPPREEDKKHPLALMGFGYGSHSC

LGMEFAQMEMKIVLSTLLRHYDWTVKPDYSAIAPVRQPSKVKDILQAYIEPLLIKHPL

DS

 

>CYP120D1 gi|126661226|ref|ZP_01732300.1| cytochrome P450 [Cyanothece sp. CCY0110]

48% to CYP120A1

MLFGNSSISVQVGEIHKQRRQILYEVFKPRMLDSYFNTMVKITEKYLDYWMKQENIVWYPEIENYTFDLA

FKFLIGLDKASESSFKPLYEQWQKGIFSLNTIKLPWTKFGKAWKARNLLKKELKEIIIKRQKEQEANDSD

ALDILIKAKDEDGKQLLVDEISDHLLNILFAGYGTLTSTLASFCRLMAQEGEILGKIREEQQRFPKQLTI

MQLKEMPYLDLVLKELLRTNTPVGTGFRQTINNCEINGYHIPKNWFIFYQISNTHKDTDIYQDPDVFDPD

RFGLDRAEGEKPFSYLPFGGGIRECLGKDFARLEMKIFSSLLVRKCQWDLLPNQNLEIEFTPVAKPKDGL

KVKISSY

 

>CYP120E1 gi|113476367| YP_722428 Trichodesmium erythraeum IMS101

MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVYQKYGPVYKTNFLGKNFIYFQGYEAIK

FILTNENKYFTYSQILRNYQRIFGENDITVLAGKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKW

IKSDYVDLYSEINNYTLDMILKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFN

QFEQIIVRRKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTSEHLD

VLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDCSFQGFRIPKGWHAYYY

ISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGGARECIGKEFAYLVIKIFISALLDNCSWK

FKENQDLTINTFPVARPAHKIEVCFTPK

 

>CYP121A1   Mycobacterium tuberculosis

MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWL

VSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAI

TPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL

FRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHV

SDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRI

NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTS

HLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERL

PVLW

 

>CYP121A1   Mycobacterium bovis subsp. bovis AF2122/97,

MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWL

VSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAI

TPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL

FRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHV

SDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRI

NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTS

HLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERL

PVLW

 

>CYP122A1   Streptomyces sp.

MSTDTPAGTPQAGRCPFAIQDAHRAILDSATVGSFDLFGIKHWL

VAAAEDVKLVTNDPRFSSAAPSEMLPDRRPGWFSGMDVPEHSRYRQKIAGDFTLRAAR

RQEEFVFEAADACLDEIEAAGPGADLVPGYAKRLPSLVINALYGLTPEEGAVLETRMR

GITGSTDLDSVKTLTDDFFAHALELVRAKRDERGDDLLHRLASAEDGEIPLSDDEATG

VFATLLFAGHDSVQQMVGYCLYALLSHPEQEGALRTRPELIDGAVEEMLRFLPVNQMG

VPRVCVADVDLRGVRISVGDNVIPLYSTANRDPEVFPDPDTFDVSRPTEGNFAFGHGV

HKCPGQHVARLLIKVACLRLLERFPDVRLVGDVPMNEGLGLFSPAELRITWGAA

 

>CYP122A2   Streptomyces hygroscopicus

MSTEAQQESTPTARCPFSIQDGHRTILETGTVGAHELFGVKQWL

VAAAEDVKLVTNDPRFSSAAPSGILGDRRPGWFSGMDSPEHNRYRQKIARDFTLRAAR

KQEEFIVRAADSCLDDIEASGPGTDLVPGYAKRLASLAIHDLYGLNEEGPVLEGQMRA

MEGGTDMESIKRLTDEFGHVLALVRAKRDEAGDRLLHRLAESGEDEILLSDEEATGVF

ATLLFAGHDSMQQMVGYSLYALLSHPEQRAALRENPDLIDGAVEELLRFLPLNQLGVP

RVCVEDVELHGQTISAGDNVIPLYSTANRDPGVFADPDTFDITRKPEHNFAFGYGIHG

CPGQHLARVLIKVATVRLFERFPDVRLAGDVPMNEGLGLFSPAELRVTWGAE

 

>CYP122A3   Streptomyces hygroscopicus var.

MSTDTHEGTPPAGRCPFAIQDGHRAILESGTVGSFDLFGVKHWL

VAAAEDVKLVTNDPRFSSAAPSEMLPDRRPGWFSGMDSPEHNRYRQKIAGDFTLRAAR

KREDFVAEAADACLDDIEAAGPGTDLIPGYAKRLPSLVINALYGLTPEEGAVLEARMR

DITGSADLDSVKTLTDDFFGHALRLVRAKRDERGEDLLHRLASADDGEISLSDDEATG

VFATLLFAGHDSVQQMVGYCLYALLSHPEQQAALRARPELVDNAVEEMLRFLPVNQMG

VPRVCVEDVDVRGVRIRAGDNVIPLYSTANRDPEVFPQPDTFDVTRPLEGNFAFGHGI

HKCPGQHIARVLIKVACLRLFERFPDVRLAGDVPMNEGLGLFSPAELRVTWGAA"

 

>CYP123A1   Mycobacterium tuberculosis

MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNF

WAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVS

KGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDR

ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAE

LDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWV

EETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGR

EIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGF

AHLPISVQAR

 

>CYP123A1   Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome complement(861053..862261)

           Gene = CYP123 100% match

           locus_tag = Mb0789c

 

>CYP123A2   Mycobacterium smegmatis

MSLPTVEPVLDPYDYDFHEDPYPYYKRLRDEAPLYRNDERNFWALSRHED

VLKGFRNSTALSNKHGVSLDPVSRNDEAHRVMSFLALDDPAHLRLRTLVS

KGFTPRRIRELEARVTEIAVQHLEIALQSDSFDFVDDFAGKLPMDVISEL

MGVPEEDRVRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRR

RRNVSDDLTSALVEAEIDGDKLTDDEIMAFLFLMVVAGNETTTKLLANAA

YWGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGT

TVPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLG

AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR

 

>CYP123A3   Mycobacterium marinum MM4930

MSVHVGGPEL VLDPYDYDFH EDPYPYYRRL RDEAPLYHNQ ELGFWALSRH RDVHQGFRNS

TTLSNRDGVS LDPVSRGPHA TKTMSFLAMD DPAHLRLRTL VSKGFTPRRI RELEPRVTEL

AVAHLDTMLD MAGGSQTVDY VAEFAGKLPM DVISELMGVP VADRDQIRAM ADGVMHREDG

VTDVPASAIE ASINLIVYYQ QMIAERRKKP SDDLTSALLA ADVDGDRLTD EEVLGFMFLM

VIAGNETTTK LLANAAFWGH KNTDQLTPIY ADLSRVPLWV EETLRYDTSS QILARTVVGE

LTLYDTTIPE GDVVLLLPGS AHRDERAFRD PDEYLIGREI GSKLLSFGSG AHFCLGAHLA

RMEARVALTE LFKRIRGYQV DEGNAVRVHS SNVRGFAHLP ITVEVA*

 

>CYP123A3   Mycobacterium ulcerans

MSVHVGGPELVLDPYDYDFHEDPYPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNS

TTLSNRDGVSLDPVSRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTEL

AVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADRDQIRAMADGVMHREDG

VTDVPASAIEASINLIVYYQQMIAERRKKPSDDLTSALLAADVDGDRLTDEEVLGFMFLM

VIAGNETTTKLLANAAFWGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGE

LTLYDTTIPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIGSKLLSFGSGAHFCLGAHLA

RMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA

 

>CYP123A4   Mycobacterium vanbaalenii PYR-1

MTISEVRLDPYNYDFHEDPYPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDPA SRGPHASKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTEIAVTHLDAMLEQATTGDAVDYVDEF AGKLPMDVISELMGVPDADRVQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTDDL TSALLEAEIDGDRLTDDEIIGFMFLMVIAGNETTTKLLANAAFWGHRNPDQLTSVYQDLARVPLWVEETL RFDTSSQILARTVSGELTLYDTTIPDGDVVLLLPGSAHRDERVFENPDDYVIGREIGSKLMSFGSGAHFC LGAHLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR

 

>CYP123A5    Rhodococcus sp. RHA1 Rha05833 and Rha05832

MTAASMPGVSHNPVTFNPYDYGFHEDPYVTYRRLREEAPLYYNEELDFWALSRHEDVVAAFRDNQRLSSANGVSLDPAAYGPHAHKTMSFLALDDPRHMRMRQLVSRGFTPRRVNELEGRILDLTRQYLDPALAAGEFDWIGEFAGKLPMDVISELMGVPEADRVELRRLADLVVHREEGVLDVPHAAMEASLYLVGYYADMLAERRRKPTEDLTSALLEAEIDGDRLTDDEIIAFMS

MRCTGVSAIRARLGNVFEDASRVPEWVEXTLRFDTSSQMVARTASVDLDFHDRTIPAGDKVLILIGSANRDSAVFEDADEYRIGRDTSNKLASFGGGTHFCLGAHMARLEARIALTELVSRIDDYDIDEANSVRVHSTNVRGFATLPMKVQVRDA

 

>CYP123B1   Mycobacterium marinum MM4833

MWQETLMSTV QLRYDPFDPE IQDDPYPVYR QLRDDAPVYH ATDTNTWVLS RHADVISALL

DHHSYSSVDG VFPTPPGSTF RESLLPMMIL MDPPRHDQLR ALVSKAFTPR RIAALTSAIE

DLADHLTGGL IQEAGSADFV ADFAAVLPAM VIADLLGVPR EDRTQFRQWS NALVQSNPTH

GETGEALAAA AAIYGYFTDF LADRRRQPRD DLMSALVCAE IDGKHLSDDE LLGFCLLLLI

AGHETTSNLL ANAAVVLADY RDTRRQLAGD ESLLGAAVEE LLRYDSPAQG LSRTLTRDVT

VHGVRMSAGE SVLLLFGSAN RDERVFADPD VFDIGRKPEH QVAFGRGIHF CLGASLARME

ARIALRALLA RVPNWEVDLE RAQRLRSGPI RGYLSLPISW SAN*

 

>CYP123B2   Mycobacterium vanbaalenii PYR-1

MVSVQIRYDPFDASILNDPYPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPTPP GSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAI LPAAVIADLLGVPATDRDQFRLWSSQLVQVDVNHGQTTDALAAAAAIYAYFTDFLADRRKNPREDLMSAL ANATVDGIGLTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDS PAQGLSRTLTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSEHQVAFGRGIHFCLGAAL ARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV

 

>CYP124A1   Mycobacterium tuberculosis

MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFA

TLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPE

LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQ

ADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSAD

IGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI

THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA

AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVA

FDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS

 

>CYP124A1   Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome 2519058..2520344

           Gene = CYP124 100% match

           locus_tag = Mb2289

 

>CYP124A1   Mycobacterium avium subsp. paratuberculosis str k10

MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRD

GAFATLRREAPISFWPAIEMDGFVAGNGYWALTKHEDVHFASRHPEIFSSVPNITIND

QTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERARRLVSSLVANH

PNGEAELVSELAGPLPLQVICDMMGIPEEDHQRVFHWTNVILGFGDPDLATDFEEFLQ

VSMDIGAYATALAEDRRVNHHDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETT

RNAISHGVLALSRYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRG

TKMKAGDKVALWYNSANRDESTFGNPWLFDVARTPNPHLGFGGGGAHFCLGANLARRE

IRVVFDELRHEIPDIVATEEPARLLSQFIHGIKRLPVAWTPPR

 

>CYP124A1   Mycobacterium marinum MM3361

MDLSTNLNTG LLPRVNGTPP PEVPLADIEL GSLEFWGRDD DFRDGAFATL RREAPISFWP

PIELAGLTAG KGHWALTKHD DIHFASRHPE IFHSSPNIVI HDQTPELAEY FGSMIVLDDP

RHQRLRSIVS RAFTPKVVAR IEASVRERAH RLVAAMIENH PDGQADLVSE LAGPLPLQII

CDMMGIPEED HEQIFHWTNV ILGFGDPDLT TDFDEFLQVS MAIGGYATAL ADDRRVNHHG

DLTTSLVEAE VDGERLSSSE IAMFFILLVV AGNETTRNAI SHGMLALSRY PDERAKWWSD

FDGLAATAVE EIVRWASPVV YMRRTLSQDV DLRGTKMAAG DKVTLWYCSA NRDEEKFADP

WTFDVTRNPN PQVGFGGGGA HFCLGANLAR REIRVVFDEL RRQMPDVVAT EEPARLLSQF

IHGIKRLPVA WSR*

 

>CYP124A1   Mycobacterium ulcerans

MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWP

PIELAGLTAGKGHWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDP

RHQRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQII

CDMMGIPEEDHEQIFHWTNVILGFGDPDLTTDFDDFLQVSMAIGGYATALADDRRVNHHG

DLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHGMLALSRYPDERAKWWSD

FDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADP

WTFDVTRNPNPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQF

IHGIKRLPVAWSR

 

>CYP124A1   Mycobacterium smegmatis

MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAPISF

HPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIVIGDQTPEL

AEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDSVRDRARRLVAGMV

DRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQIFHWTNVILGFGDP

DLTTDFDEFVTVAMDIGAYATALADQRRSAPADDLTTSLVQAEVDGERLT

SAEVASFFILLVVAGNETTRNAISHGVLALTRYPEQRRLWWSRFDELAPT

AVEEIVRWASPVSYMRRTVTRDTELAGTALPAGSKVTLWYGSANRDETKF

DNPWMFDVQRHPNPHVGFGGGGAHFCLGANLARREITVLFSELHRHLPDI

VATEEPDRLQSAFIHGIKRLPVAWR

 

>CYP124A1   Mycobacterium vanbaalenii PYR-1

MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDNEV AGHWALTRHDDVFYASRHPEIFSSALGITVGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAL IEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDPDIA TDFDEFVSVAMGIGAYATQLADDRRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAI SHGVLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA NRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAF

IHGIKRLPVSWSA

 

>CYP124B1   Streptomyces cinnamonensis

MGLTVGPDNAKRGIVPITDSKPAATFPDLVDPSFWARPHAERVA

LFEEMRGLPRPAFIRQNMPGVPWTFGYHALVKYADIVEVSRRPQDFSSNGATTIIGLP

PELDEYYGSMINMDNPEHSRLRRIVSRSFGRNMIPEFEAVATRTARRIIDELIARGPG

DFIRPVAAEMPIAVLSDMMGIPAEDHDFLFDRSNTIVGPLDPDYVPDRADSERAVIEA

SRELGDYIAGLRAERLAAPGNDLITKLVQVQADGEQLTRQELVSFFILLVIAGMETTR

NAISHALVLLTEHPEQKQLLLSDFDTHAPNAVEEILRVSTPINWMRRVATRDCDMNGH

RFRRGDRIFLFYWSGNRDESVFPDPYRFDITRGTNAHVTFGAVGPHVCLGAHLARMEI

TVLYRELLAALPQIHAVGQPRRLDSSFIEGIKHLHCAF

 

>CYP124B2   Streptomyces nanchangensis NS3226

MNRGVVSPTEATPASSAKATRPPDFMDPSFWLRPRDERAEVFEK

LRALPGPEFVPPRLPWGPLASGYYALSKHADICEVSRRPQDFSSEGATAILPPEMDEF

YGSMINMDNPEHSRLRRIVARSFGRGMAPKFDAMSRRVARRIVDELIERGPGDFIRPA

AEMPIAVLSTMMGIPGEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDY

IGRLREDRLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQAL

VLLTEHPDQRQLLLSDFELHAKGAVEEILRVGTPINWMRRTATGDCEMNGHRFRKGDE

IFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFCLGAHLARIEIIAMLREL

LASLPDIRVEGEPVRLASSFIEGFKELSCTF

 

>CYP124B2 ortholog SBI_3705 Streptomyces bingchengensis

99% to CYP124B2 Streptomyces nanchangensis NS3226 
only 3 aa diffs

MDPSFWLRPRDERAEVFEKLRALPGPEFVPPRLPWGPLASGYYALSKHAD

ICEVSRRPQDFSSEGATAILPPEMDEFYGSMINMDNPEHSRLRRIVARSF

GRGMVPKFDAMSRRVARRIVDELIERGPGDFIRPAAEMPIAVLSTMMGIS

GEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDYIGRLRED

RLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQA

LVLLTEHPDQRQLLLSDFELHARGAVEEILRVGTPINWMRRTATGDCEMN

GHRFRKGDEIFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFC

LGAHLARIEIIAMLRELLASLPDIRVEGEPVRLASSFIEGFKELSCTF

 

>CYP124C1    Rhodococcus sp. RHA1 Rha04649

VTGSASEKIISPASRAFWDRSFAGRRAMFEELRQRSPIEFHAETAGPGFWSVVGYDDVVAVSRNPEVFSSAKGFTIDDVPAEILEFAMSMIAMDDPRHRRLRGIVQSAFTAASVRGIAERVRGTAAQIAADLPRDAEFDFVPDVATRLPVQVICELIGIPENDRPMILAAAADVVAGGGDQEFVTAPGGAAGLGQIYGYALELGERRKADPGEDLTSRLVSTMVDGEALAPTEFGSFVILLITAGFETTRQALAWALLLLSEHPDQKELLLADFAGHIDNTIDEVIRFASPVPYMRRTATVDTELGGAHIAAGDKVVMWYLSANHDERVFDGPGRFDITRANAGKHLGFGAKDIHHCLGVNLARLELRVMLEELFTAHPTLHAVGEPELLLSAFISGVAALPARTRDGR

 

>CYP124F1 Frankia alni ACN14a

MSLIADVDLDDLDWWTRPAAERDAYFASVRASGERPYFPELDLAGNTRGRGFYAVTRYADVMEVSRRPED

FCSGEGTNIFDQPLDLREFFGSIIAMDNPQHARQRRIISRGFTAKNLEALRANVGEVTREVLATVAEKGE

CDFVTEVAALIPLRIVNDMMGIPRSQEQFIFESTNKLLGASDPEYVPDQSPRGVAKNLSRVGDDFAELLR

ELAADRQRNPGDDLISLLVAAEGENLTAQELASFFILLVGAGNETTRNAIAHGLLALTQNPDQRALWASD

VDGLTPTAVDEVVRWASPVLHMRRTVTADGVRLGDQEFREGDKLVLWYRSANQDESVFPDGTRFDVRRDL

TPPHLGFGAPGPHFCLGAHLARLELSVVFKALFEYLPDIHAVEEPQFLRTNFLHGIKHLKAAYTPTTVRA

 

>CYP124F2 Frankia alni ACN14a

MPGTRGLPGDVLDDLSWWTRPAAERDATFAWLRAHDPRPYVPELDLTGAPRGGGFWALTRLDDVREVSRR

PADFCSGQGSLIFDQPPRLREFRGSIIDMDNPEHARQRRIVARGFTPKAVAALVEDIARTSREVISAVAR

RGECDFVTEVAALLPLRIVNNLLGIPRSEERFLFEQTNILMGASDPEYVPDQTPRSVARAVHGAGQAMSG

LLEELARDRIRNPQDDLVSSLVAAQEEENLTPTELATFFNLLVGAGNETTRNALAHGLSALTRFPDQREL

WRSDLDRYTPGAVEELLRWASPVLYMRRTVARDGVTLGEQRFDAGDKVVLWYRSANQDEAYFDDATAFRV

TRDPNPHVTFGAPGPHHCLGANLARVELAIAFRTLFELLPDIEATAEPDLLRSNFLHGVKHLPARFTPTA

PRP

 

>CYP124G1 SGR529 Streptomyces griseus
42% to CYP124B1     Streptomyces cinnamonensis
42% to CYP268A2     Mycobacterium marinum MM3761
top 19 hits are CYP124 or CYP268. These families overlap
MLLAAGGRTMAWRTVEVMDMTVPYQLSEGRVLRAADVDLADPAFWRLPRPVRLRAFALLRELEEPVLFTPRAGTARTAGKPFRALVRHADVRTASRTPQVFASAPGVTTPEPAGWAKALFGNSMVNMDGPEHAALRRIISRRFTPRLLAEAEENVGRLAGRLVDELIAERPRDFMPSAASRLPLEVICDLMGVPAAYRARIAEQIDHASEHVGVERRGRARLRIPGRGLASLARMQFVMGRLARERRQRPEDDLVSALVNADIDGEALSGRQLGAFFSLLLVAGVETTRNAIAHGLFLLDRHPEQRELLRSDFDRYIDGAVDEIVRHSTPIIQFRRTVAEECALGGRTFLPGEKVALIYASANRDETVFTHPDRFDITRSPNPHLGYGGGGPHHCLGAHLARLEMTALFRELIARRPVMRDLGDPDLVDSNFDNRVGSLPFTFGPTFT
 

>CYP125A1   Mycobacterium tuberculosis

MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFA

ELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKN

DIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAA

AGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSA

ELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNS

ITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKG

QRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFN

AVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH

 

>CYP125A1   Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome complement(3927359..3928660)

           Gene = CYP125A1 100% match

           locus_tag =Mb3575c

 

>CYP125A2   Streptomyces avermitilis

MPCPALPDGFDLTDPDLLHQRVPLPEFAELRRTAPVHWVPQQHG

LAGFQDDGYWAVTRHADVKYVSTHPELFSSYLNTAIIRFHETMQREQIDAQRLFMLNM

DPPEHTRVRQIVQRGFTPRAIRALEDTLRRRARSIVETALADAGPDGSFDFVTQVACE

LPLQAIAELIGIPQDDRAKIFDWSNKMIAYDDPEYAITEEVGAESATELIAYAMNMAA

DRKQCPAKDIVSTLVAAEDVGNLASDEFGFFVLMLAVAGNETTRNAITHGMHAFLTHP

DQWDLYKRERPATAAEEIVRWATPVVSFQRTATQDTELGGKQIRKGDRVGIFYSSANH

DPEVFEHPDVFDITRDPNPHLGFGGGGPHFCLGKSLAVVEIDLIFGAIADVMPGLRLT

GDPRRLRSAWLNGVKGLQVSAG

 

>CYP125A3   Mycobacterium smegmatis

MPTPNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGD

KGYWLVTKHADVKEVSRRSDVFGSSPDGAIPVWPQDMTREAVDLQRAVLL

NMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAAQGAGDFV

EQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSS

FELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAV

AGNETTRNSITHGMIAFAQNPDQWELYKKERPETAADEIVRWATPVSAFQ

RTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHV

GFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNG

IKHWQVDYTGAGKASVSGAPGTCPVAH

 

>CYP125A4   Mycobacterium smegmatis

MSDSALHLPAGFDFTDPDIYAERLPVDELAELRRVAPIWWNAQPIGAGGF

DDGGFWVVTKHKDVKEISLRSDVFSSLEKTALPRYPEGTVQDQIEQGRFV

LLNMDAPHHTHLRKIISRAFTPRAVERLRDDLAERARAIVRAAAEEGSGD

FVEQVACELPLQAIAGLMGVPQEDRRKLFDWSNQMVGNQDPEFVANDGAS

AAVELITYGMQLAAQRAAAPGDDLVTKLVQADVEGHKLSDDEFGFFVVLL

AVAGNETTRNSITQGMMAFTDHRDQWELFKRERPVTTADEIVRWATPVTS

FQRTALADTEVSGVRIKKGQRVVMFYRSANFDEDVFTDPYRFDILRDPNP

HVGFGGTGAHYCIGANLARMTIDLIFNAIADEMPDLTPISEPVRLRSGWL

NGIKHWQVDYRGDAAKHRAAQASSQADR

 

>CYP125A5P   Mycobacterium smegmatis

MATMNTCPFGNGYDFTDPDVLFRGIPVEEFAVLRKTAPVWWNQQGESIFDDGG

YWVISRHEDIKTISRDGGEVWSTNAKGAVMRLPDGVTAEQLDLTKALLIN

HDAPEHTRLRKLVSRLFTPRSVAALEEKLAVAAHDIVAEAKAEGSGNFVE

DIAMKLPLLAIADLIGVPEADREKIFAWSNAIINTDDPDFDSDPTVANAE

LMGYAYTMAEERRRCPADDIVTRLVQADVSGESLGEVEFAFFVILLAVAG

NETTRNAITHGMNAFFENPDQWELFKRERPITAVDEIVRWATPVHCFQRT

AVVDTEIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGF

GGNGAHYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVK

DLQVSYRG*PARLIYYSRMRTHGWSGSAPATD

 

>CYP125A6   Mycobacterium marinum MM2783

MPAAEPTATS VPNLPPGFDF TDPDIYAERL PVAELAEMRR SAPIWWNEQP TGCGGFDDGG

FWVVTKHKDV KEISLRSDVF SSLQKTALPR YKDGTVDEQI ERGKFVLLNM DAPQHTRLRK

IVSRAFTPRA VERLRDDLRE RARRIVEAAA AEGRGDFVEQ VSCELPLQAI AGLMGVPQED

RKKLFHWSNE MVGDQDPEFA TNDALTASVE LIMYGMQMAA DRAKNPGQDL VTKLVEADID

GHKLSDDEFG FFVILLAVAG NETTRNSITQ GMMAFTDFPD QWELYKRERP VTTADEIVRW

ATPVTSFQRT ALQDYELSGV RIKKGQRVVM FYRSANFDED VFDDPYTFNI LRDPNPHVGF

GGTGAHYCIG ANLARMTIDL MFNAIADVMP DLESISQPER LRSGWLNGIK HWQVDYHSDS

SGKCPVAH*

 

>CYP125A6P  Mycobacterium ulcerans

MPAAEPTATSVPNLPPGFDFTDPDIYAERLPVAELAEMRRSAPIWWNEQPTGCGGFDDGG

FWVVTKHKDVKEISLRSDVFSSLQKTALPRYKDGTVDEQIERGKFVLLNMDAPQHTRLRK

IVSRAFTPRAVERLRDDLRQRARRIVEAAAAEGRGDFVEQVSCELPLQAIAGLMGVPQED

RKKLFHWSNEMVGDPGLRRC LLEANSGQDPRFAAADHDDRELRRALRRQGVGDQDPEFATNDALTASAELIMYGMQMAAD

RAKNPGQDLVTKLVEADIDGHKLSDDEFGFFVILLAVAGNETTRNSITQGMMAFIDFPDQ

WELYKRERPVTTADEIVRWATPMTSFQRTALEDYELSGVRIKKGQRVVMFYRSANFDEDV

FDDPYTFNILRDPNPHVGFGGTGAHYCIGANLARMTIDLMFHAIADVMPDLESISRPERL

RSGWLNGIKHWQVDYHSDSSGKCPVAH

 

>CYP125A7   Mycobacterium marinum MM5032

MPCPNLPPGF DFTDPDIYAE RLPVEEFAEL RSSEPIWWDE QLPGQGGGFH DGGFWAITKL

KDVKEVSRRS DVFSSYENGV IPRFKNDIAR EDIDVQRFVM LNMDAPHHTR LRKIISRGFT

PRAIGRLHDE LNDRAQNIAK AAAAAGSGDF VEQVSCELPL QAIAGLLGIP QEDRGKLFDW

SNEMTGTEDP EFAHIDAKAS SVELIGYAMK MAEEKAKNPG DDIVTQLIQA DIDGEKLSDD

EFGFFVVMLA VAGNETTRNS ITQGMMAFAD NPEQWELYKR ERPETAADEI VRWATPVTSF

QRTALEDYEL SGVQIKKGQR VLMFYRSANF DEEVFEDPFS FNILRNPNPH VGFGGTGAHY

CIGANLARMT INLIFNAVAD HMPDLTPIAA PERLRSGWLN GIKHWQVDYT GKCPVSH*

 

>CYP125A7   Mycobacterium ulcerans

VPCPNLPPGFDFTDPDIYAERLPVEEFAELRSSEPIWWDEQFPGQGGGFHDGGFWAITKL

KDVKEVSRRSDVFSSYENGVIPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFT

PRAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQEDRGKLFDW

SNEMTGTEDPEFAHIDAKASSVELIGYAMKMAEEKAKNPGDDIVTQLIQADIDGEKLSDD

EFGFFVVMLAVAGNETTRNSITQGMMAFADNPEQWELYKRERPGTAADEIVRWATPVTSF

QRTALEDYELSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGAHY

CIGANLARMTINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVDYTGKCPVSH

 

>CYP125A8   Streptomyces scabies SCAB65311

MLRQESPMPC PALPDGFDLT DPDLLHHRVP LPEFAELRRA EPVHWIPQAP GIAGFADEGY

WAVTRHADVK YVSTHPELFS STVNTAIIRF NEHIERDAID AQRLILLNMD PPEHTRVRQI

VQRVFTPRAI RALEDNLRHR ALNIAREAGA HAGPFDFVTE VACELPLQAI AELIGIPQED

RIRIFEWSNR MISYDDPEYA ITEEVGQQSA MELIAYAMNM AADRKQCPAK DIVTTLVAAE

DEGNLTSDEF GFFVLMLAVA GNETTRNAIT HGMHAFLTHP DQWDLYKRER PATAAEEIVR

WAAPVNAFQR TATQDLELGG KRISKGDRVG IFYASANHDP DVFTDPDTFD ITRDPNPHLG

FGGGGPHFCL GKSLAVLEID LIFNAIADAM PGLRLAGEPS RLRSAWINGV KHLQVTTA

 

>CYP125A9   Mycobacterium vanbaalenii PYR-1

MPGPNSCPISPEFDFLDASLNLERLPVEELAELRKSEPVHWVDVPGGTGGFGDRGYWLVTKHADVKEVSK HNEIFGSSPDGAIPVWPQEMTREAIDLQKAVLLNMDAPQHTRLRKIISRGFTPRAVGRLEDELRARAQRI AATAATEGSGDFVEQVSCELPLQAIAELLGVPQEDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELITYA MKMAEERAKNPTEDIVTKLIEADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFSRNPDQWELY KKERPETAADEIVRWATPVSAFQRTALEDTELGGVQIKKGQRVVMSYRSANFDEEVFENPHSFDIMRNPN PHVGFGGTGAHYCIGANLAKMTINLMFNAIADAMPDLKPIGDPERLKSGWLNGIKHWQVDYTGQCPVQH

 

>CYP125A10   Mycobacterium vanbaalenii PYR-1

MATPTLPPGFDFTDPDLNLERLPVEELAELRRCAPIWWNEQTSGGAGPFGDGGYWVVTKHRDVKEISKHS EVFSSQQKTALPRYPEGSTTEQVETGSLVLLNMDAPRHTHLRKIISRGFTPRAVERLREDLAQRAHNIAK SAAAAGAGDFVEQVSCELPLQAIAGLLGVPLEDRKKLFDWSNQMVSDDDPEFAHYDNRNAATELIMYAMQ LAALRAEQPGEDIVTKLIEADVDGHKLTDDEFGFFMVLLAVAGNETTRNSITHGMIAFTEHPDQWELFKR ERPATAVDEIVRWATPVTSFQRTALRDYELSGVQIKKGQRVVMSYRSANFDEEVFDDPFTFDIMRDPNPH VGFGGTGAHYCIGANLARMTIDLMFNAIADHLPDLSSAGTPDRLRSGWLNGIKHWQVDYTGPSGCPVAH

 

>CYP125A11   Mycobacterium vanbaalenii PYR-1

MTATQSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTAPVWWNEQADSIFDDGGYWVISRHEDVKAISRN STQWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEDRLADAAREIV RSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFHWTNAIMNTDDPEFDADPTMANAELMGYAYS MAEERRRCPADDIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDNPAQWELFKR ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPH LAFGGNGAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR

 

>CYP125A12P  Mycobacterium leprae

1 PGFDFPDPEIYTEQLSV*EPAEMCQAETI**NEQPIGRSGFYDDDY 138

     XXXXXXXXXXXXXX

 174 HSGTFSNLEKTALACYQEGMNDEQISRGKLVLLNIDASQYTRLHKIISPGFIP*AAEQLR 353

 354 DDLXXXXXXXXXXXXXXX 362

 410 SGDFVEHVSCELSRQAAIAGLPSG 481

 480 VPQEDCKKLFHWSN 521

 522 QTVGAQDPKFATNDPMVTSVKLIM*AMQIAADRAKPLGQVIVTNLVEADIEGHKLSKDEFGSF 710

 713 VIMLTAAGKENTRNCIMQSMMQFTNFPD*WELYK 814

 816 KKAPGTTADKIIRQATLVMS 875

 876 FQRTVLK*YELSSVSIKKGQRVVVIYRSANFDEKVLTIRLPCSIMRNPT 1022

1022 PHAGFNDTNVHYCIGIN 1072

1073 LARMTIDRMFHAIAESMPNL*STGKPK*LRSGWLNGVKHWQVD 1201

 

>CYP125A13  Streptomyces peucetius

MSCPHLPQGFDFTDPDLLQARVPHPEFAEMRRTAPVWWCEQPAGISGFDDEGYWAVTRHA

DVRHVSTHPELFSSNTNTAVIRFNESISRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTP

RAVRSLEAALRRRARSIVETAAAGAKPDGSFDFVTNIAVELPLQAIAELVGVPQEDRSKI

FDWSNKMAAYDDPEYAITEEVGTEAAMEIVSYAMNLAAARKECPAQDIVSRLVAAEGERQ

PVLRRIRLLRHPAGGGRGTRPPR

NAISHGMH

GVPHPPRAVGELYSGCAPTRRPRENLRLGGTPGGFLSNGPGTQERGSLGGAAYX

 

>CYP125A14P  Rhodococcus sp. RHA1 Rha05823

VGSFPCPQKIEQVLLSGQGLNELSFASRPACASMLVERVPHHGVVYGLGQETAVAQPNLPEGFDFTDPDVYAERIPYQEFAELRKTAPIWWNPQPPEIGGFHDDGYWVVSKLEDVKEVSRRSDVFSTHENTAIVRFADDIPRENIEMQRFILINKDAPEHTKLRKLVSRGFTPRAINSLREELTERAEKIVKEAAESGAGDFVTQVACELPLQAIAELLGVPQEDRLKVFDWSNQMTGYDDPELDIDPQAASMEILGYAYQMADERKKCPADDIVTTLIEADIDGNELSPEEFGFFVILLAVAGNETTRNAITHGMMAFLDHPDQWELYKKERPKTTADEIVRWATPVNSFQRTALEDTELGGVQIKKGQRVVMLYGSANFDEDAFENPEKFDIMRENNPHVGFGGTGAHFCLGANLARLEIDLIFNAIADHLPDISKLGDPRRLRSGWLNGIKEFQVDYKTASGGCPVRH

 

>CYP125A15   Salinispora tropica (marine actinomycete)

MTEPRIPVGFDFTDPAVLERRVPREEFAELRRTAPVWWNVQPRGSAGFDDDGYWVVTRYA

DVMAVSRDSDTYSTRENTAIARFQPGTTRADLEMQRVIMLNVDPPEHTKLRAIVSRGFTP

RAINALRGSLAERAERIVRDAAVRGTGDFVADVACELPLQAIAELIGVPQHHRRKVFDWS

NQLIGYDDPAYGVDPLTAAAELLAYAMEMANERQLNPSDDLVTKLVNAQIDGEHLTTDEF

GFFVMLLAVAGNETTRNAITHGMLAFLEHPEQWELFKAERPRSAVEEIIRWATPVNVFQR

TALVDTTLGGQAISAGQRVALFYGSANFDESVFEEPERFDITRSPNPHLGFGGSGAHFCL

GANLARLEIELIFHSIADHMPDIRKVAEPRRLRSGWINGIREMPVRYR

 

>CYP125A16 SBI_1118 Streptomyces bingchengensis

79% to CYP125A2 Streptomyces avermitilis 

MSCPALPEGFDFTDPDIYQQRLPFPEFAQLRQTDRVWWIPQPHGVAGFDD

DGYWAVTRHADVKEVSTKPEIFSSHLNTAIIRFNEHIHRDQIDVQKLIML

NMDPPEHTRVRQIVQRGFTPRAIRALEDALRERATRIVAGAKEDGSGDFV

TDVAFGMPLQAIAELIGVPQQDRSKIFDWSNKMVAYDDPELAITEEIGAE

SAMELISYAMNLAADRKACPAKDIVSQLVAAEDQGNLASDEFGFFVLLLA

VAGNETTRNAISHGMHAFLTHPDQWELFKRERPASAADEIVRWATPVMSF

QRTATQDTELGGQRIAAGQRVGIFYSSANHDPEVFDRPEDFDITRDPNPH

LGFGGGGPHFCLGKSLAELEIRLIFNAIADAMPDVRLAGDPRRLRSPWLN

GIKELQVNYG

 

>CYP125A19 SGR5169 Streptomyces griseus

MRCPHLPDGFDFTDPDLLQSRVPHPEFALMRETAPVWWCTQPRNISGFGDEGYWAVTRHADVKYVSTHPELFSSNTNTAVIRFNETISRDQIDVQKLIMLNMDPPEHTRVRQIVQRGFTPRAVRSLEAALRSRARSIVGTAQASADAHGSFDFVTDIAVELPLQAIAELIGVPQEDRSKIFDWSNKMAAYDDPEYAITEEVGAEAAMEIVAYSMNLAAARKECPAQDIVSQLVAAEGEGNLSSDEFGFFVILLAVAGNETTRNAISHGMHAFLTHPEQWELYKRERPKTTAEEIVRWATPVVSFQRTATQDVELGGQRIRKGERVGLFYSSANNDPEVFDAPEAFDITRDPNPHLGFGGGGPHFCLGKSLAVMEIDLIFNAIADVLPDLRLLEDPRRLRSAWLNGIKELRVTTAAA

 

>CYP125B1    Rhodococcus sp. RHA1 Rha05835

MTASRIDLKCPDVYTEGVPYAFFDHLRSSEPVYWQPEENGTGFWAVTRHADVVAVSRDSVTFSSAVGTTQIDDFDEQTRAKQAAMLVNLDPPDHTRLRQLVSRGFTPRTVKVLEGHIRDICTRIVDRLLEARDVDFVPEAAAPLPLEVIAALLGAPPGDVDRLYDWSNRMIGFDDPEYGTTQADGELAAAEIFLYANELAAQRRIEPRDDIVTKLVQPDENGDTLTEMEFNMFFVLLVVAGNETTRNATAGGMQAFIDHPDQWRRLQSEPDLASSAVEEILRWVTPVMDFRRTATRDAYIGDQLVRAGDKVVIYYPSANRDEAVFDEPYRFDIGRSPNPQIAFGGSGVHFCLGAHLARLELRILFETLAARIDRVESTGPVARLRSNFISGIKTMPVRIHPRSPV

 

>CYP125C1    Rhodococcus sp. RHA1 Rha04272

MTLSALHTDLGSPDAYIHGVPHQVFAELRRHEPVAWIEEPAGEGFAGGPGFWAVTRYDDVMTVSKKPDVFSSHKGASFLRDQSPQDLAALQQMMLNLDPPDHSQMRSIVSKVFTPKMVRGMFDSIADHARAIVDALPDDGEIDLVEHVSAEMPLRVLADVLGVPSEDRHLLYDWTNRMVGLDDPSYGGREAFLSAFIEMFEYSAAQTRAKRTEPGSDVWSLIVNAEVDGTQLSPEELNRFFQLLVIAGNETTRNLLTGAILTLGEHPGEREKLADDPALLPNAIEEVLRFHSPVIQFRRTVTRSTELGGKQMHEGQKVVIFYVSANRDEAQFDDPDTFRIDRGAANHLAFGAGTHFCLGNSLARLEAKVLLEALFTRFPHWQVTGPPDRFRSNFIHGIKKLPVHLGKATS

 

>CYP125D1    Rhodococcus sp. RHA1 Rha05286

VQLADVDLYNPDTFAKGVPHEMFAVLRREAPVYRHLDERGDPFWCVTRHADIVTVNRDAETYSSWRGATYIDDLSPDDLAGQQLMMLNMDPPDHTALRKIVSKGFTPRRIGQLHEILARRATTIVDAVIERGECDFVVDVASELPLQAIADFLGVPQEDRKLIFDLTNQMIGSSDPEFHLEDGQERAAAAQMFAYSLEMFEDRKKHPRDDIATALIQADVHGEKLGELDFNMFFMLLAVAGNETTRNAISHTQLALMEHPEERRKVLEDPSKLDALIEEGLRWATPVMQFRRTATTDTVLHDVEISEGDRVVIWHMSGNRDEAVFDDPYTFDIDRPTGHYSQHIAFGGGGHHFCLGANLARAEMKVMLSEILRRMPDMEQTAPAQRLRSNFINGLKHMPVTFTPSSL

 

>CYP125E1    Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_7184

MTPQTVDILD PDLYLAGAPH DRFELLRREA PVHWHPEPAG RGFWAITRHA DVARISRDPA 
AFCSGRGLFI EDLPPGDMRD NPDVMIMMDP PRHARFRALV SKGFTPRVIQ RLESHVRELV 
TRLIDDACER GGCDFASDIA GKLPLSVILE VIGVPREDQE QMLDWTTRFF GASDPAYGVT 
PEELNAVLHN MNAYAHQLAE QRRKEPKDDM LSLLMAAEVD GEKLSYTEFG GFFNLLLTAG 
HDTTKNLISN GMLALLEHPD QRRRLLDDPS LLPTAIEEML RFTPPVYYFR RSAVRDIELH 
GQRIAAGDKV VLWYVSANRD ETVFSDPHRF DVGRTPNEHL SFGIGPHVCL GLVLARLEAR 
VAFEELLRRL PDLELAGPAV RLRSNWVSGV KSMPVRCARP AR

 

>CYP125F1    Mycobacterium avium subsp. paratuberculosis str.

MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY

RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD

APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE

CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ

YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG

ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER

VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV

LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA

 

>CYP125F2   Mycobacterium vanbaalenii PYR-1

MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA

 

>CYP125F3   Mycobacterium flavescens PYR-GCK

MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT

GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG

YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR

HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD

IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF

FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT

ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG

ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA

 

>CYP125G1   Salinispora tropica (marine actinomycete)

MSTEVVSTGNRADIAHPATYAAGVPYAEFARLRRDKPVSWVPEAALWRRSGEGRILSQGP

GFWAVTTHEGVVAASRQPEVFSSGRQGAFLADPRTTADLEQARQLLVNMDAPQHARVRKL

VTAVFTPRAIRALGDSVTAHARNLVERAVRQEECDVVADLAAELPLLVLADLLGLPREDR

HLLYQWSNNLVGFDDPEYGGGDVEAYRKTFFEAFQYALSVAGERRRAPREDLMTLLATSE

VDGRRLTDREFCNFWLLLVVAGNETTRHLITGSVLALVDNPMQRERLVADDTLLPSAVDE

LLRWVSPIMQFRRTAIVDTELCGTPIAAGDKVVLWYTSANRDAAVFEAPDELRLHRNPNP

HLSFGMGPHFCLGAHLARLEARTMLRELAPHLSRFRLTGPVVRLESNFVNGVKSLPGSFT

GQ

 

>CYP126A1   Mycobacterium tuberculosis

MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEH

TPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPR

HTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICI

LLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA

DDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQL

QTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRD

PSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP

AEWTRSNRHTGIRHLVVELRGG

 

>CYP126A1   Mycobacterium bovis subsp. bovis AF2122/97,

MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEH

TPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPR

HTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICI

LLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA

DDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQL

QTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRD

PSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP

AEWTRSNRHTGIRHLVVELRGG

 

>CYP126A2   Mycobacterium smegmatis

MRADLTDLDNFADGFPHALFEAHRREAPVYWHEPTEHTPDGEGFWSVATY

AETLAVLRDPVTFSSVTGGSRPYGGTLLQDLAIAGQVLNMMDDPRHAQIR

RLVSSGLTPRMIARVEEDLRVRARRLLDAVEPGVPLDFLVEVAAELPMQM

ICILLGVPESERHWLFHAIEPQFDFSGSRTASVGQLTPEEAGNRMYRYGM

ELIAAKRAAPTDDMLSVVANAHDAELSDLELYLFFSLLFSAGAETTRNAV

AGGLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVE

LGGCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFGQGVHY

CLGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA

 

>CYP126A3   Mycobacterium marinum MM4915

MTSAGVLSKI DFTDLDNFAD GFPHALFAIH RREAPVYWHE PTDNTPDGEG FWSVATYPET

LEVLRDPVTY SSVTGGQRPF GGTLLQDLAI AGQVLNMMDD PRHAQIRRLV SSGLTPRMIR

RVEDDLRART RRLLDAVVPG EPFDFLVDVA AELPMQMICI LLGVPESERH WLFEAIEPQF

DFGGSRKAAV SQLSVAQTAE EAASRMYSYG QELIASKRAA PTDDMLSVVA NAMVDGGDEP

ALSDLELYLF FSLLFSAGAE TTRNAVAGGL LALAEHPEQL RALRGDLDLL PTAVEEMVRW

TSPSPSKRRT ATRDVTLAGC SIEAGQKVQI WEGSANRDAR IFDHADEFDI TRKPNPHLGF

GQGVHYCLGA NLARLELRVL FEELLGRFGA VLVGQPVEWT RSNRHTGIRH LVVELFGG*

 

>CYP126A3   Mycobacterium ulcerans

VTSAGVLSKIDFTDLDNFADGFPHALFAIHRREAPVYWHEPTDNTPDGEGFWSVATYPET

LEVLRDPVTYSSVTGGQRPFGGTLLQDLAIAGQVLNMMDDPRHAQIRRLVSSGLTPRMIR

RVEDDLRARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESERHWLFEAIEPQF

DFGGSRKAAVSQLSVAQTAEEAASRMYSYGQDLIASKRAAPTDDMLSVVANAMVDGGDEP

ALSDLELYLFFSLLFSAGAETTRNAVAGGLLALAEHPEQLRALRGDLDLLPTAVEEMVRW

TSPSPSKRRTATRDVTLAGCSIEAGQKVQIWEGSANRDARIFDHADEFDITRKPNPHLGF

GQGVHYCLGANLARLELRVLFEELLGRFGVVLVGQPVEWTRSNRHTGIRHLVVELFGG

 

>CYP126A4   Mycobacterium vanbaalenii PYR-1

MRVAGALAAVDFTDLDNFAAGFPHGLFALHREQAPVYWHEPTENTPDGEGFWSVATHAETLAVFRDPETY SSVTGGERAFGGTLLQDLPIAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLRERARRLLDEVEPG TPVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIEPSFDFGGARKASITRLSVEEAGSRMFEYGQELI AAKRAQPGDDMLSVVVNSGDPQLSDLESYLFFNLLFSAGAETTRNAIAGGLLALIENPDAYRALRADPGL LPTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLG FGQGVHYCLGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR

 

>CYP126A5P  Mycobacterium leprae

DRSLIPSAIEEGSRSETPNWASVTRITIA*LAIGGKTILPNAGVDILMGSANRDGSRWTE 363

364 PNTFDIHWPRQAHTTLAGSHMCLGIGLAQLDTRVMLNNLFD 486

 

>CYP126B1    Saccharopolyspora erythraea NRRL23338

VTVDQPELPTSRNASESVSDQLPAVLGGFDLTDQVRFSGGFPHEVFNRLRADEPILLHPP

GRTRDGESFWVLSRYEDVVEAAANPVFSSQGGGSREGGGTHLDDLPAGTYAGGMLNMMDD

PRHQLIKDIVSPAVCPSAVAALEPVVRERASALVSTVLERGTCDLQAEVAGRYSVEVVAA

LLGVPRQDWSRLVDWAEIAMGYEDRDEGEATGRSQAALLDMYKYGCELVRAKRAEPAGDF

MSLIATGEIPEGHGQAPLVDYEREVFFNLISLAGTEPTRNAIAIGLLALVEHPEQWQALR

ADRSLLDGAVEEALRWSSPTPYNRRTATEDIRFRDVLIREGDKVTLWWASANRDERVFAD

PFRFDVRRSPNPHLAFGHGAHTCLGPALARMELRVLLEELLDRVERIELTGPVPWARNSK

HTVALRVPVALTASS

 

>CYP127A1   Rhizobium sp.

MSDLRRKRVKTNPIPDHVPPALVRHFSLFTSPGMAPTPNGDPHA

AVACVHDDGPPIFYSPSNTRDGRGTWVITRARDQRRVLEDTETFSSHRSIFASALGEH

WPVIPLELDPPAHGVFRALLNPLFSSRRVLALEPTIHARAGALIDCIAKEKTSCDVMK

DFALPFTFSVFLSFLGLSQRRSEVLVGWVSDLLHGNAEKRRAAARSVVAFIDEMAAMR

RKSPAVDFMTFVVQAKIEGRSLTEEEVRGIGVLFLVAGLDTVAAAIGFDMAYLARNPK

HQELLRNEPARLGLAAEELLRAYSTVQIIRVATKDIEFEGVPIREGDYVSCPAMIANR

DPSEFKCPNTIDLARQDNQHTAFGYGPHLCHGAHLARREIVIGLREWLARIPAFRIKE

GTAPITHGGHVFGISNIILTWA

 

>CYP127A2   Rhizobium sp. BR816

MILRRNHVALKPVPDHVPPEMVRDFSLFTSPGMQRMPNGDPHAA

VARVHGGPPIFYSPDNTRDSRGTWVITRAKDQRRVLQDSESFSSHRSIFASALGENWP

MIPLELDPPAHGVFRSLLNPLFSPKRVMALEPAIRQRAMALIDRICASRTSCDVMSDF

AFPFAVNIFLRFLGLSDERLDTYVGWGKDLLHGDSVKRTAAALAIVAFIDELAAMRRK

EPTDDVMTFVVETEVDGRRLTDEEVRGIGVLVFVAGLDTVATAIGFDLAHLARNPNDQ

ALLRGEPDRIVPAVEELLRAYSTVQIIRVARKNIDFEGAPIRKGDYISCATMIANRDP

AEFECPNTIDLAREDNRHTAFAYGPHRCLGSHLARREIVIGLEEWLSRIPDFRIKEGT

APITFGGHVFGIENLILDWS

 

>CYP127A3v1 Mesorhizobium loti

1 MAINPVPDHV PPEMVRDFSL FTSPGMPPTP NGDPHAAVAC AHDGPPIFYS PYNTQDGRGT

 61 WVITRAADQR KVLQDTETFS SHRSIFSSIL GETWPTIPLE LDPPAHGAFR SLLSPLLSPK

121 RVTALEPAVR ERAIALIDRI TASATSCDVM KDFAFPFTVS IFLRFLGLPD QGLDTFVGWA

181 KDLLHGDDVE RPVAARKIVA FIDELATNRR KDPVDDLMTF IVQAQIEGRR LTDGEIRGIG

241 VLVFVAGLDT VAAAIGFDLA YLARNLKDQE LLRSEPARIL LATEELLRAY PPIQLIRVAT

301 KDIDFEGAPI RKGDYVSCAT MIANRDPEEF ESPNTVDLAR DHNRHAAFGY GPHRCLGSHL

361 ARREIVIGLE EWLARIPTFR IKEGTAPITC GGHVFGIENL ILDWS

 

>CYP127A3v2  Mesorhizobium loti

            GenEMBL AL672114 complement(100678..101895)

            Strain R7A symbiosis island

            Gene = msi332

            2 DIFFS with CYP127A3v1

 

>CYP127A4   Rhizobium etli symbiotic plasmid p42d

MHLCSERIYRKRGTRENPMSTGRAGEASKKFRLRPTKQRGFRAA

RRSDRCIACHWRLALLRLEIWRSTILLAPSPRRIRSRRRGFDDRRKAVATIRVPEHVP

PEMVKDFSLFTSPGMERMPNGDPHAAVACLHNGPRIFYSPCNTRDGRGTWVIVRAQDQ

RKLLQDTGTFSSHRSLFASALGENWPLIPLELDPPAHSVFRSLLNPLLSPRRIMELEP

AVRDRAIALISKISASSTSCDILTDFAFPFAVSIFLRLLGLSDERLNTFVGWGKDLLH

GDGIRRTAAARTILAFIDELAAMRRKEPADDFMTFVVQAKVDGRLLRDQEIHGIGVLL

FVAGLDTVATAIGFDLAYLARNPTEQELLRSKPDRIVLAAEELLRAYSTVQMIRVATK

DINFEGAPIRKGDYISCATMIANRDPVEFENPNTIDLAREDNRHTAFAYGPHRCLGSH

LARREIIIGLEEWLSRIPDFRIKDGTAPITYGGHVFGMENLILDWS

 

>CYP128A1   Mycobacterium tuberculosis

MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTR

RRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDF

DPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVT

FSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPAD

VVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGF

RRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMI

STLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPA

GSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILR

EIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP

 

>CYP128A1   Mycobacterium bovis subsp. bovis AF2122/97,

MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTR

RRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDF

DPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVT

FSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPAD

VVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGF

RRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMI

STLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPA

GSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILR

EIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP

 

>CYP129A1       Steptomyces sp.

MSGEAPRVAVDPFSCPMMTMQRKPEVHDAFREAGPVVEVNAPAG

GPAWVITDDALAREVLADPRFVKDPDLAPTAWRGVDDGLDIPVPELRPFTLIAVDGED

HRRLRRIHAPAFNPRRLAERTDRIAAIADRLLTELADSSDRSGEPAELIGGFAYHFPL

LVICELLGVPVTDPAMAREAVGVLKALGLGGPQSAGGDGTDPAGDVPDTSALESLLLE

AVHAARRKDTRTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAE

VLAGRLAADADGDAISRFVEEALRHHPPVPYTLWRFAATEVVIRGVRLPRGAPVLVDI

EGTNTDGRHHDAPHAFHPDRPSRRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPQ

ARLAVPYEELRWCRKGAQTARLTDLPVWLR

 

>CYP129A2   Streptomyces peucetius

MAVDPFACPMMTMQRKPEVHDAFREAGPVVEVNAPAGGPAWVIT

DDALAREVLADPRFVKDPDLAPAAWRGVDDGLDIPVPELRPFTLIAVDGEAHRRLRRI

HAPAFNPRRLAERTDRIAAIAGRLLTELADASGRSGKPAELIGGFAYHFPLLVICELL

GVPVTDPAMAREAVSVLKALGLGGPQSGGGDGTDPAGGVPDTSALESLLLEAVHSARR

NDTPTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAEVLAGRLA

ADADEDAVSRFVEEALRYHPPVPYTLWRFAATEVTIGGVRLPRGAPVLVDIEGTNTDG

RHHDAPHAFHPDRPSWRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPEARLAVPY

DELRWCRKGAQTARLTELPVWLR

 

>CYP130A1   Mycobacterium tuberculosis

MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEY

DYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRK

LVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPE

EDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVA

AGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI

PDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAE

LDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSY

VRRPLSVPFRVTS

 

>CYP130A1X  Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome

           CYP130 lies in a deletion in M. bovis

 

>CYP130A2   Mycobacterium smegmatis

MSHPAVAFELANADTWADPWDMYTALRDHDPVHHVVPPERPHHDYF

VLSRHADIWAAARDHETYSSAQGLTVNYGELELIGLADNPPFVMQDPPTH

TEFRKLVSRGFTPRQVEAVEPQVREFVVERLERLRAEGGGDIVAELFKPL

PSMVVAHYLGVPEADRAQFDGWTEAIVAANSEAGSALGAGDAVMSMTGYF

AELIERRRREPGDDTISHLVAAGADDEAVDVLSILAFTFTMVTGGNDTTT

GMLGGAVQLLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATR

DVTIGDTTIPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSH

GAHFCLGAAAARMQSRVALTELLTRCPDFTVDLDAVVWAGGSYVRRPLSV

PFRAGA

 

>CYP130A3    Rhodococcus sp. RHA1 Rha08652

MGNVSHYRYMTAHVSSVSFVPRSGQSWRAPWQMYAGLRDHDPVHHVVPEDAPGNDYWVLSRHADVYAAARDPETFSSAAGLTTTYGELEKIGLQDNPPLVMLDPPDHTAFRRLVSKGFTPRQVTAVEPNVRAFVVERIERLREAGAGDVVKELFKPLPSMVVAHYLGVPDEDRAQFDGWTEAIVAANAQGDTLQATGAVTELMGYFTGLIERRRTDPGDDTISHLVAGGMGADGDITGLLSILGFAFTMVTGGNDTTTGMLGGAVQLLTEHRDQRRDLIEHPELVRDAVEELLRLTAPVQGLARTVTRDVEIEGTVVPEGRKVLLLYGSANRDPRRFGPDAEVLDVRRSPKQILTFSHGAHHCLGAAAARMQARIALEELLARCPDFTVDIDAVVYADGNYVRRPTSVPFRVREA

 

>CYP130A4   Mycobacterium marinum MM4184

MSVDVSHRAP VAFQLATAAT WPDPWPMYRA LRDQDPVHHV IPAHQPDQDY YVLSRHADVW

AAARDHQTFS SAQGLTVNYG DLEMIGLQDN PPMVMQDPPA HTEFRKLVSR GFTPRQVEAV

EPKVRDFVVE RIERLRAQGG GDIVTELFKP LPSMVVAHYL GVPEQDRTQF DGWTQAIVAA

NTAEGGIAGA LATVGDAVGS MMAYFTSLIE RRRAKPEDDT ISHLVAAGVG ADGDIAGTLS

ILAFTFTMVT GGNDTVTGML GGSMPLLHRR PDQRRLLTDN PELITDAVEE LLRLTSPVQG

LARTVTHDVT IGNVTIPAGR RALLLYGSAN RDERQYGPDA GELDVRRCPR NILTFSHGAH

HCLGAAAARM QSRVALTELL ARCPDFEVDE SRIVWSGGSY VRRPLSLPFE VRS*

 

>CYP130A4P  Mycobacterium ulcerans

MSHRAPVAFQLATAATWPDPWPMYRALRDQDPVHHVIPTHQPDQDYYVLSRHADVWAAAR

DHQTFSSAQGLTVNYGDLEMIGLQDNPPMVMQDPPAHTEFRKLVSRGFTPRQVEAVEPKV

RDFVVERIERLRAQGAATSSPTCSSPCRRWWSHTISGYPNRTGHSSMGGPRPSSRPTPPR

AASRARWPRSAMWSGR*LSSMVVAHYLGVPEQDRAQFDGWTQAIVAANTAEGGIAGALAT

VGDVVGSMMAYFTSLIERRRAKPEDDTISHLVAAGVGADGDIAGTLSILAFTFTMITGGN

DTVTGMFGGSMPLLHRRPDQRRLLTDNPELITDAVEELLRLTSPVRGLARTVTHDVTIGN

VTIPAGRRALLLYGSANRDERQYGPDAGELDVRRCPRNILTFSHGAHHCLGAAAARMQSR

VALTELLARCPDFEVDESRIVWSGGSYVRRPLSLPFEVRS

 

>CYP130A5   Mycobacterium vanbaalenii PYR-1

MTAVLSHGSPVHFALADASTWADPWPMYRALRDHDPVHHVVPEDRPNHDYYVLSRHADIWAAARDHQTFS SALGLTVNYGELDLIGLADNPPMVMQDPPVHTEFRKLVARGFTPRQVEAVEPKVHDFVVDRIEHLRANGG GDIVAELFKPLPSMVVAHYLGVPDEDRGKFDGWTDAIVAANTSAGGLGGALDTLGDALGEMMSYFTALIE RRRTEPEDDTISHLVAAGVGADGDISGVLSILAFTFTMVTGGNDTTTGMLGGSVQLLHRRPDQRTMLAEN PDLIPDAVDEFLRLTSPVQMLGRTVTHDVTIGDVTIPEGRRVMFLYGSGNRDERQYGDDAGELDVTRKPR NILTFSHGAHHCLGAAAARMQSRVALTELLTRIPDFEVDESGIAWAGGSYVRRPVSVPFTVTH

 

>CYP130A6P   Mycobacterium leprae strain TN

VMSHRFRFTTADIWPNPWSMYRTLRDHEAVHHVVPANQPEDDYYVLPRHADVWSMAMRS

HAKLSSAQRLTVNYSDMELIGLQDNPPMVMQDQPV*TKCRKLVSRRFTPRQTNVVEPKVR

HFVVEHIEQLRAKGSVDIVTELFKPLPPMVVAHYFGFPEKVRSQFDGW

TTAADGGGALFRFPRKSPITIRRLAPAIVAANTADAGGITNELDVAGYAVESMLAYFTR

IATGGNNTVTGMLGG*MPL

SHRRKQHRHWHARRLDAVKDTAEAD

LLRLTSSVRGLMRTTTRDVAIGHTTVSPGRRVLMRYGQAKRDER*YSAAAS*LDVTW*

PPNILIFSHGAH

YLGAKVTRMQRR

VRLTELLARYPDFEVDESSIAWAGGKLHTTP

 

>CYP131A1       Streptomyces peucetius

MPTPTSAPPAAPTDSELGRHLLTVRGFHFVFGALGDPYARRLRG

EADHLSLGELVRDRGPLHGSALGTWVTADGGISARLLDDPLLGPRHPASEGPQEHVLE

NVWETWRTCHVTPLGEDLLTPAAADSDRLAALLGPVLGPRTCTAWQVDAGRAVHRVLD

GLPPHFDVVSDLARPAIAGSLAAVLGLPDEARAELPDLLAACGPVLDSALCPPRLPVA

RAMTQALRRVRELMAAAVANHLTAPADGAVSALLAVDPGGGRDPGDTVTAAVLSTVVG

AETAITTVANAVMALLKHDEQWSLLRADPGRAADAVEETLRWAPPVTLRSLITQGEVQ

IGGETLEADQHVVVLVDAAQRDPALYEDPDRFRLDRPRSPGFTHMALAGRDHLGLVAP

LVRVQCTAVLRALAERLPGLRAEGEPLRRGRSPVVRAPLSLRLAQK

 

>CYP131A2     Streptomyces sp.

MTMPTPTSAPPAAPTNSELGRHLLTVRGFHFVFGALGDPYARRL

RGEADHLSLGELVRDRGPLHRSALGTWVTADGETSAGLLDDPLLGPRHPASEGLQ

 

>CYP132A1  Mycobacterium tuberculosis

MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGS

DITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWA

RHRGALNSTFARRHLRGLVGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALF

SQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLRE

MQEITLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGH

ETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRY

FSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPT

DRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRP

KHGVHVIGRRR

 

>CYP132A1   Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome complement(1566263..1567648)

           Gene = CYP132 1 aa diff

           locus_tag = Mb1429c

 

>CYP133A1     Erwinia herbicola

MQLHELMDPDYSDNPFPLYRKLHQQGPLIPAGDKIIISGSHAVVDALLNDRRVGKNYMESVRVRFGDDAAGLPLFQGISRMFLVLNPPDHNRL

 

>CYP133B1v1   Xylella fastidiosa 9a5c

1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYMES

 61 MRVRYGDSAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL

121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG IAVSKIAKVF DPSPMSADEL

181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY

241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG

301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC

361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

 

>CYP133B1v2  Xylella fastidiosa Temecula1

1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYIES

 61 IRLRYGDTAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL

121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG MAVSKIAKVL DPSPMSADEL

181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY

241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG

301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC

361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

 

>CYP133B1v3 Xylella fastidiosa Dixon

MKLTDLSNPAILENPYPLYETLRAQAPFVSIGPNALMTGRYSLV

DSLLHNRNMGKNYMESMRVRYGDSAADMPLFQAFNRMFITINPPAHTHLRGLVMQAFT

GRESESMRPLVIDTAHQLIDNFEQKPSVDLVAEFAFPFPMQIICKMMDVDIGDAVTLG

MAVSKIAKVFDPSPMSADELVHASTAYEELAQYFTKLIELRRTHPGTDLISMFLRAEE

DGEKLTHDEIVSNVIMLLIAGYETTSNMIGNALIALHRHPEQLTLLKSDLSLMPQAVS

ECLRYDGSVQFTMRAAMDDIEVEGELVPRGTVVFLMLGAANRDPAQFTHPDQLDITRK

QGRLQSFGAGIHHCLGYRLALIELECALTALFERLPHLRLAHLDALNWNQRSNLRGVN

TLIVDLHAKN

 

>CYP133B2v1  Xylella fastidiosa, section 33 of 22

            AE003887 CDS 6723..7925

            82% to AE003889 48% to CYP133A1

 

>CYP133B2v2  Xylella fastidiosa Ann-1

MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV

DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT

GRESESMRPLATDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLS

VAVSNIAKVFDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE

EGQKLTHDEIVSNVILLLLSGYETASNMIGNALIALHRHPKQLARLKSDLSLMPQTVL

ECLRYDGSVQFTVRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLEITRK

QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN

ALIADLHP

 

>CYP133B2v3  Xylella fastidiosa Dixon

MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV

DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT

GRESESMRPLAIDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMHVDISDAISLS

VAVSNLAKVLDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE

EGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAVL

ECLRYDGSVQFTIRAAIDDVSIEGDVVPRGTIVFLMLGAANRDPVQFTDPDHLEITRK

QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN

ALIADLHP

 

>CYP133B3   Xanthomonas axonopodis pv. citri str. 306

1 MLLSDLATPQ FRHDPYPTYA RLREEGPLVQ VADGRLMSGR YAVVDRLLSD RRVGRDYLQS

 61 VRLRYGEAAV HLPLFQGMSR MFLLLNPPLH TQLRGLMTQA FGARQMESMR EVASDIAAGL

121 IDAFQANGHC DLLTEFAFPL PIAIICRMLD IAAADVTALS HATSALAKVF DPMMTAEELQ

181 ATSVAYDQLA TYFHGVIAQR RSAGGDDLIA RFIQAEDNGR RLSEEEIVSN VILLFFAGHE

241 TTSNMICNAL VALHRHPQQL RLLQETPGLL PNAVLECMRY DSSVQMATRT ALQDFEIEGV

301 AVPRGTMLYL MLGAANHDTL QFTDPQVLDI RRQQGRALSL GGGIHHCLGN RLALIEVEAA

361 LACLLARLPA LRLEQLDTLS WNDRANLRGV DALLASW

 

>CYP133B4   Xanthomonas campestris pv. Campestris str. ATCC 33913

1 MQLSDFATPA FRQDPYPMYA RLRAAGPLVQ ISDNGWVSGH YTVVDALLSD RRVGRNYLDS

 61 IRVRYGANAA EMPLFQGMSR MFLLLNPPVH TQQRALMTKA FGARQLEALR EVAVDTADAL

121 LDQHEDRRSC DLLNDFAMPM TISLICRMLG LAVTDVAALG QASSALAKVF DPLMRPEDMA

181 QATAAYTTLE QYFRAIVLQR RDTQEDDLIA RLIAAEDHGQ RMPVDDIVSN VIMLFTAGHE

241 TTANMICNAL IALHRHPEQL QLLRDTPTLM PNAVLECMRY DSSVQVAMRS VLQPLQVEGT

301 TLPVGAILYL MLGSANHDAE QFTAPQQLDL RRQQGRALSF GGGVHHCLGN RLALIELETA

361 LERLLQRAPA LRLPELDNLS WNERANLRGI QALHATW

 

>CYP133B5   Ralstonia solanacearum GMI1000 megaplasmid

MKLADLSTPSFLENPYPLYETLRSQGPFVRIGPNALMTGHYSIV

DALLHNRQMGKSYMESIRLRYGDEGPNMPLFQGFSRMFLMLNPPMHTRLRGLMMQVFN

ARQIESMREVATATAHQLIDDFEQKPSADLVAEFAFPLPVRIICQMMDLDIDDAMALG

VGVSKLAKVFDPAPMSADALVETSAAYEELAQYFTKVIEARRAQPGTDLISMLMRAEE

NGETLTHDEIVSNVILLFIAGHETTSNMIGNALIALHRNPQQLDLLKREPSRMPNAVL

ECLRYDGSVQVTIRAALEDVEVEGEVLPRGTTVFLMLGAANRDPAQFTDPDQLDIGRQ

QGRLQTFGAGIHHCLGYRLALIELESALGALFERLPNLRLTNLDQLSWNQRGNLRGVN

ALMAAW

 

>CYP134A1   Bacillus subtilis

MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS

RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD

HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG

VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL

SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY

KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK

SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT

RGPVSLLVAFDGA

 

>CYP134A2P  Bacillus cereus ATCC 14579

1 MIGATNCDSN VFERPDKFNV YRPDIDIKKA FSGTARHLAF GLSIYNCVGV AFAKLKIEID

61 STIKDNISRK KLRDIKDFVK KTSKMN

 

>CYP134B1   Photorhabdus luminescens subsp. laumondii TTO1

MAKLSSFNIHDPKFIKNPYDFYDILHKQDLVYFEQSQNSYFIGK

YEDVDAILKSSIFNTKPLTALAEPVMGDRVLAQMEGEEHACKRKFIMQGLSRDYFNRY

YEPMIRKITEDLLQPYMEKGNIDIVNDFGRDYAVLVTLSILGLPSDNYRDIAEWHKGI

ASFITQFDQTELEKMHSLECSQKLIRLLKPIIDQRRRNPSKDIISIFCQDTAMSMSEI

TALCLNILLAATEPADKILAMMLNHLISNPSMLDVVLKDRSLVRDAFEETLRLTSPVQ

LIPREASEDVTISGIDIPKGAVVFCMIGAANRDPSVFHKPNEFDLYRRKNTTSPQKAN

RKRHLAFGAGTHACAAAAFSLSQLEVSSNIILDLLHNLRFADHYHYQETGVYTRGPSK

LLLSFDPIASSAIKE

 

>CYP135A1    Mycobacterium tuberculosis

MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFS

LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHAR

MRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFG

VTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIA

SRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLW

ELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPA

GTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTE

GAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP

 

>CYP135A1    Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome complement(393726..395075)

            Gene = CYP135A1 1 aa diff

            locus_tag = Mb0334c

 

>CYP135B1    Mycobacterium tuberculosis

MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFT

LHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDR

RRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGA

SDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIAD

RRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALER

LTRHPVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAG

YRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGAT

FAMVEMRVVLREILRRVELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATSQA

TAQGAGCPAARGGGPSRAVGSQ

 

>CYP135B1    Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome 660693..662111

            Gene = CYP135B1 100% match

            locus_tag = Mb0583

 

>CYP135B2   Mycobacterium smegmatis

MSTPGTLPPGPPLPAFVQTAMMLRHWSRFVSACRRRYGDVFTLRIASMGT

WVYLADPADIKTVFAGDPTVFHAGEANSMLSGLLGETSVLVIDEDVHRDR

RRLMLAPFARDAVARQTGVMAEVAATNIASWPVGTPFPVAPKMAEIALEV

ILRTVIGATEPARLAALRHVMPQLLGIGPWQSLAIASPGLQRRRPWRTLQ

RNLAEADRLLYAEIAACRAGPDLASRPDALAMLVRAANDEGRTMTDRELR

DQLMTLLVAGHETTATGLSWTLERLIRHPAVLDKAVAAARTTDGSGEAYL

DAVVRESLRIRPVVFEAGRVLTEPVELGGYLLPAGTLVAPSIGLVHASAD

VYPDPDRFEPDRMLASTQAPSTWLPFGGGNRRCLGATFALVEMRVVLREI

LHRVDLFATTARGEKQRLKHVTMIPHRGGRICVRALRDVAPAPMTCPAEA

RRA

 

>CYP135B3   Mycobacterium marinum MM4483

MKGNAYDVTT MIARTRTALP PGPRLPRSVQ DALLIRHGPR FLAACRRRYG DVFTLRVASI

GTMVYVADPA VIKSVFAGDP NTLHGGAASM LRGLLGDSSL LVVDDRAHRD RRRLMLAPFH

RDVIERQAGL IAEIAAENVT GWPVGTPFAA ATKMSEITLE VILRTVIGTS DAARLAALRA

VMPRLLDLRP WETLALAKPN LLQRGPWRSL HRRIAEADEL LYAEIAEHRT DPGLSGRADT

LAMLIQAAYD DGRTMADGEL RDQLMTLLVA GHDNTAAGLC WALERLTRHP AVLAKAVQAA

DASAAGDPAG NEYLDAVVKE TLRARPVVFD LGRVLRKPIE LAGYLLPEGV MVVPSIGLVH

GSAALYPGPE RFDPDRMLGV ILGPTGWLPF GGGSRRCLGA AFAMAEMRVV LREILRRVEL

CPTTAVDERQ KLKNVILVPH RGGRILVRAM RGVPAPD*

 

>CYP135B4   Mycobacterium marinum MM0938

MTKTATLPPG PRLPRAVQAA LMLRHAPRFL TACKRRYGSV FTLRVAGLGT MVNVTDPVVI

KKVFAGDPRV FHAGEANTML AGLLGESSLL VVDDDVHRDR RRMMLPPFQR EAVAHQAQLM

SEIAAENIAG WPVGRTFAVA PKMAEITLEV ILRTVIGATD PDRLAALRKV MPRLLNVGPW

ETLALAKPDL LSRRAWRRLR RAIDEANELL YAEIAERRAD PNLAERTDVL ATLVRAVDGD

TAKPSGRMTD EELRDQLMTL LVAGHDTTAT GLAWALERLT RHPAILAKAV RAAEASAAGD

PSGDEYLDAL AKETLRIRPV VFDVGRILTE PTELAGYQLP AGTMVVASIG LVHANAEVYP

DPDRFDPDRM IDATLTPTTW LPFGGGNRRC LGATFAMVEM RVVLREILRR VDLATTTAPD

ERYKLKHVIL VPHRDARIRV RAITAVSPAV PEAPGCPVAH AKS*

 

>CYP135B5   Mycobacterium vanbaalenii PYR-1

MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLRCGPRFVAACRRRYGSAFTLRVASMGTLVYLT DPADIKTVFAGDPDIYHAGEANSMLKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAA DNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGPWETLAIANQDLLRRRP WRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVRAGDMSDKELRDQLITLLVAGHDTTATALSW ALERLTRHPAVLAKAVRAARDGDDDYLDAVAKETLRDRPVVFDVGRVLKAPVELAGYRLPAGVMVIPGLV AVHADSQIYPHADRFDPDRMLGATLSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARG

EHRRLKHVIFVPHRGARIRVRAKRVVAAEAPKCPMSGPA

 

>CYP135B6   Mycobacterium marinum MM2978

MPHSNSGVLP PGPPLSRSLQ AALMLLRGPQ FLAACRRRYG DVFTLRIARM GTQVYLADPR

DIKTVFTGDT HIFHAGDANA LLSGLIGDSS LMVLDEEAHR CRRRTMLAPF HRDAVARQAG

LMAEIAADNV AGWPAGRTFP VTVRMSEITL EVILRTVIGA TDPARLAALR TAVPRLLSMG

PWGTLALANP KLLSRRPWRG LRKRIADVDN LLYAEITDRR NDAELGKRAD VLAMLIRTEG

NDNAMTDREL RDQLVTLLVA GYDTSATGLA WALERLTRHP TILTRAVAAA HASAAGDAAG

DEYLDAVVKE TLRIRPLAFA VGRVLAAPVE VAGYQLPAGA WALPGIGLVH ASAALYPDPD

RFDPDRMIGV SPGPTTWLPF GGGARRCLGA TFALVEMRVV LREVLRRAEL ITTTAADETP

KLKYVTLIPS RGARISVRTI KNIPPASPVG AEKPATTPGC PATENVGATR PAF*

 

>CYP136A1    Mycobacterium tuberculosis

MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKK

LAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVA

ALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSR

LAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVT

KVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTV

LCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESD

RHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIA

YPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLEIK

TILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR

 

>CYP136A1   Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome 3376038..3377516

           Gene = CYP136 1 aa diff

           locus_tag = Mb3085

 

>CYP136A1   Mycobacterium marinum MM1634

MATISTPAYL LDQAQRRLTP SFNNFPGMGM VERWLLKTQF PETTLADPPP GSDLKPVVGD

AGLPILGHLI EMLRGGPDYL MFLYRTKGPV VFGDSPVLPA VVALGPDAAQ VIYSNRNKDY

SQQGWVPVIG PFFRRGLMLL DFEEHMFHRR IMQEAFVRSR LVGYVEHMDE VASRAIAGEW

ATNDARFLLY PAMKKLTLDI ASMVFMGHEP GTDHELVTKV NRAFTTTTRA GNAVIRTSVP

PFTWWRGIRA RQLLENYFAA RVTERRGQEG NDLLTVLCHT ADEDGNRFSD QDIVNHMIFL

MMAAHDTSTS TATTMAYHLA AHPEWQQRCR DESDRLGDGP LDIEALEKLE SLDLVMNESI

RLVTPVQWAM RQTVRDTELL GYYLPKGTNV IAYPGMNHRL PEFWTDPMTF DPDRFAEPRN

EHKRHRYAFT PFGGGAHKCL GMVFGQLEIK TILHRLLRRY RLELARPDYR ACWDYGGMPV

PKDGMPIVLR PL*

 

>CYP136A1   Mycobacterium ulcerans

VATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPPGSDLKPVVGD

AGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLSAVVALGPDAAQVIYSNRNKDY

SQQGWVPVIGPFFRRGLMLLDFEEHMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEW

ATNDARFLLYPAMKKLTLDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVP

PFTWWRGIRARQLLENYFAARVTERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMIFL

MMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEKLESLDLVMNESI

RLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRN

EHKRHRYAFTPFGGGAHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYRACWDYGGMPV

PKDGMPIVLRPL

 

>CYP136A1   Mycobacterium smegmatis

MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP

AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS

SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR

RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD

IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ

ARKTLEDYFLSRIDEKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMIF

LMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEKL

ETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINHR

LPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLEI

KTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR

 

>CYP136A1   Mycobacterium vanbaalenii PYR-1

MPSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPPAGSDLKPILGDAGLPIIGHMI EIFRGGPDFILEIYRKHGPVYFAESPALSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLL DFDEHMFHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLDIASEVFMGVPA GTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIKARKTLEDYFSSRIGEKRRSESTDMFSVLCHS ADEDGQSFTDDQIVSHMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEKLE TYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINHRLPELWTDPEKFDPERFAEPRS EHKKHRYAFAPFGGGAHKCIGMVFGQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLR PLH

 

>CYP136B1   Mycobacterium smegmatis

MTIPAAEAAADAKVRLQTAVAGITARYPSREHALAAPPPGSGLKPV

MGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVGFRVALLMGPE

ALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRDHRRIMQQAF

TRSALNGYLDLMRPGIDRTVRSWPAAQRFPFYTSVKHLLLDQAAEVFIGA

ELGPEADQLSRDFHDTVCGGQAVIRADVPGGVWSRGLRARRRLERYFAGQ

LPARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNHMIFLLMAAHDTSAIA

ISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDLDSAYPLLDAAFKESL

RMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGVYASMRLADWWPEPDEF

DPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQFANMNVKAIMLHLLRHF

RWHVPAGYQPRMTWGTGPTPADGLPITLERLSA

 

>CYP136B2   Mycobacterium flavescens PYR-GCK

MSALPQSLPG LPAASAKLRF QSAAASVTSR YPSRVRPLSR PPAGSGLKPV LGNYGFPVLG

HHLSTFVEPL EFARERYERF GPVSWAGGIG FRVVQLMGPE ALETAWINRD KAFSSTRGWA

PVIGPFFHRG IMLLDFEEHR DHRRIMQQAF TRSALDGYLT LMRPGISRTV TSWPTAAGFP

FYTAIKKLLL DQAAEVFVGA VLGAEADRLS SDFHDTVCGG QAMIRADVPG GTWARGLRAR

ERLERYFAAQ IPDRRAGTGA DLFSMMCRSR SEDGDSFSDA DIVNHMIFLL MAAHDTSAIA

ISMLVYELGR NLRWQDALRD EADAGDGLGL ADLDGAYPLL DAAFKEILRM YAPAGTLFRQ

TVTDTEVCGH YIPRRTQVAI NVYASLRLAD WWPDPDRFDP GRFLGGGDAA AVHRYAFAPF

GGGVHKCIGQ QFADMNVKLV MHQLLRQFRW RVAPGYRPLM TWGTGPTPAD GLPISLQRLSGG

 

>CYP136B3   Mycobacterium sp. KMS

MTALTAQLTS PANTHRLQVA GAALTSRFPS REEPLATPPP GSNLKPVMGN YGFPFLGHTL

SALAEPLDFA RRRYDMYGPV SWAGGVGFRV VALMGPDALE TAWINRDKVF SSTRGWAPVI

GPFFHRGIML LDFEEHRDHR RIMQQAFART ALDGYLELMR PGIDRTLGGW PASDAFPFYP

SIKHLLLEQA AEVFVGTHLG PESDQLSADF HDTVRGGQAL LRADVPGGVW ARGLRARKRL

ERYFGDQIAD RQRGDGADLF SMLCRSEDDD GARFTPADIV NHMIFLLMAA HDTTAIALSM

LVYELGRNQK WQKTLRDEAV GRPNDAPAVG DLDAYPLLDA AFKEILRMYA PAGTLFRQTT

RDTDILGHFV PAKTQVAINV HASMRLADWW PDPDTFDPAR FIDQPGARAA VSRYAFAPFG

GGAHKCIGQQ FADMTVKTTM HQMLRRFEWS VADGYRIPLT WGTGPTPADD LPITLRTLTT

 

>CYP136B4   Nocardia farcinica IFM 10152

MVEITRSVAK GFGMSLQLPT TVSAVSDNAR HLRTRLSWQA QRAGLQVVKR YPTRIRPLAE

PPPGSGLKPV LGDFGPPGIG YTLHTLADPM GFSRERFERL GPVSWLGVLG RPVVSVAGPE

AFEEVLLDRD KVYSAQRGWE WLIGPFFHGG VMLRDFDDHM FHRRILQQAF TRPRLHGYQD

LTSPLLRRGI ESWRPAAEFH IHTAIKQLLL QQATEVFAGA ELGRESVALA HAFEDAVHGG

TAMVRANVPG GVWARGLRGR RRLEDYFRRE LPAKRAGEGN DLFSVLSRAT TEEGHTFTDE

EVVQHMIFVM LAAHDTSTIA SSMLVYELGR HPEWQDKLRA EAIGLGKESV GYDDLDELPL

LDMAFKEALR MYAPVAQQAR ETIADTALCG HYLPRGTLVM CGPYMMMRTA RYWRDPDEFD

PERFAPERRE DKSHRFAWAP FGGGAHKCIG LYFGGMTVKA VLYQMLTRFR WSVRPGYEPL

LVAGTGPTPA DGLPIRLERL AR

 

>CYP136C1    Rhodococcus sp. RHA1  Rha02367

MPKVLAAPPPQSTLQPISGNAGFPVIGHSLDYFRDPMGLLQSRWDRYGPVSWLSMAGKRWVTVLGPDGCQTVLQNKDRAFVNSDGWSVLIGPFFHRGLMLLDGDEHLAHRRIMQQAFTRDRLSRYTEALHPAVEKGLDGWQPTAGFAAYPALKELTLDLATSIFMGGAEGSTPREMAEINRAFIDCVQAATSVIRYPLLGTRWKRGIDGRARLEEFFRRYLPARRAGAGEDLFSALCHIESEEGQRFSDDDVVNHMIFLLMAAHDTSTITLSTMMQYLGQHPDWQERCRRQSAALGTSTPTYDQLDELTDLDLVMKECLRLVPPVPVVARRAVEDTEVLGHYIPRGTYMSVVVHFTHHMPEYWPDPERFDPERFAPERREDKVHRFAWEPFGGGVHKCLGMHFAGAEIKTVMHHLLRRFHWHVSPGYVAPLNYTSLPFPSDGQPVDLYHRVGGADTP

 

>CYP136C2    Rhodococcus sp. RHA1 Rha06567

MRRELRFVMSKILAVPPAQSQLQPVSGRSGLPGVGHVLEYIRDPLALMQKHWDRYGEVSWFSMVGRRWVAVLGPDACQEVLQNKDRAFVNGDGWSVLIGPFFHGGLMLLDSEEHLRHRRIMQQAFTRSRLENTVDVLNPAIDSALDAWTPTNGFRAYTALKALTLDLATDIFMGGAEGSTESEISSVKKAFVDCVQAATSVVRYPVPGTRWKRGLDGRRVLEDFFRQYLPARRSHETDDLFSVLCHIESEAGQRFSDDEVVDHMIFLLMAAHDTSTITISTMMQYLGQHPQWQDRCRAESLALGTPAPSYADLDGLDSLDLVMKECLRIVSPVPVMARRAVRDTQVQGHFVPAGTYAAVVPHFTHHMPQYWPEPERFDPERFAEHRREDKVHRYAWEPFGGGVHKCLGMHFAGAEIKAIMHHLLLRFDWHVDADYVAPLNFTSLPFPSDGQPVDLRLLATS

 

>CYP136C3 Frankia sp. CcI3

MAVRGSRGPVPGDGGPPLVGYTLRYLHDPAQHWRQRYDRYGPVSWERTFGLRVVSLLGPDATGLALRNHE

QAFANGPGQQRIAGPFFRRGLSMLDFDEHRHHRRILAGAFAPDRLRGYLAGMNPSIERGVAGWRPGARFQ

VYPAVKQLTLELATRIFMGERLGPEADRFNAALFACIRAPGAVVRVPAPGLRWSRGLAGRRYLEEFLRLR

VPAKRAGSGTDMFSRLCHAEAEDGSRLSDDDVVNHMILMMVAAHDTSTITMTSMSYYLARHPEWQQRCRE

ESLALGTPAVDHADLDRLPSLALVMKEALRLVTPVPILLRATVKDIDVLGVTVPAGTVAALALAFTHQMP

EYWPSPERFDPERFADHRREDKVHPYAWQPFGGGPHTCIGLHFAGQQVKAILHQMLLRYRWSLAPGYRIS

LDRFPLPVPRDGLPVQLEKIT

 

>CYP136D1    Mycobacterium abscessus

1 MDAVEAAQRP GGTMTNHLLA PAHHVKERLS SVIMVPAPHA VDDRWRRWSR DWPVRELAPA

 61 PAGSGLKAVR GDAGLPFVGH TLDYIRFGSD FSRERYDRLG SVSWMGAFGT KMVVIAGPDA

121 TREAFTSEAK AFSQDGWSFL IDAFFHRGLM LMSFDEHLMH RRIMQEAFTR PRLTGYVEQV

181 TPCVRSAVPA WPVGPSVRIY PLLKELTLDI ATDVFMGGRG KDESDAVNKA FVATVRAASS

241 LVRAPLPGTR FRAGVQGRRV LEDYFFRHLP AARAGETEDL FAALCQATTE DGERFSDEDV

301 VNHMIFLMMA AHDTSTITTT AVTYFLAKYP QWQEAAAAEA AAIGDGLPDI EALEKMTVID

361 RVIKEALRLL APVPLVMRKT VRDVAIDGYH IPSNTLCAIT PAVNHFDRTI WNDPERFDPS

421 RFDEPRREDQ HHRFAWVPFG GGAHKCIGMQ FGTLEVKAIL HRMLRSFTWK VPENYHVRWD

481 NTSLPIPVDG LPLEMKRR

 

>CYP136D2   Mycobacterium marinum MM3135 OR 3315 (TYPO)

MANQLLAITR HPKERLTSVL LAPAPRVVDD KWRQWSRDWR VRELAPAPAG SGLRAVLGDA

GLPLLGHTVD YIRFGSEFSR ERYERLGSVS WMGAFGTKMV VIAGPDATRE AFTSEAKAFS

QDGWSFLIDA FFHRGLMLMS FDEHLMHRRI MQEAFTRPRL TGYVGQVAPC VRAAVPAWPT

GPSVRIYPLL KNLTLDIATD VFMGGRGKDE SAAVNEAFVS TVRAASSFVR VPLPGTRFRA

GVHGRRVLED YFSRHLPAAR AGETDDLFAA LCQATTEDGE RFSDEDVINH MIFLMMAAHD

TSTITTTAVT YFLAKHPEWQ EKAAAEARSF GHDSPDIDEL ERMTVLDLIL KEALRLLAPV

PLVMRKTVRD VAIDGYHIPR ETLCAITPAV NHFDRRIWSD PDRFDPSRFD EPRREDQQHR

FAWVPFGGGA HKCIGMQFGT LEVKAILHQM LRTYTWTVPN DYHVRWDNTS LPIPVDGLPV

TLRHR*

 

>CYP137A1    Mycobacterium tuberculosis

MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGL

PAPRGFRAAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGDVAIVSDSALAKE

VFTAPTDVLLGGEGVGPAAAIYGSGSMFVQEEPEHLRRRKLLTPPLHGAALDRYVPII

ENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLG

VSEQLTVRYALRRLGALRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLV

SARGESGEQLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGG

GEAFTTAVINETLRVRPPAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYE

HPHEFRPERFLGTRPQTYAWVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAVDD

EPERIVRRSIMLVPRRGTRVRFRPAR

 

>CYP137A1   Mycobacterium bovis subsp. bovis AF2122/97,

           NC_002945 complete genome complement(4064642..4066072)

           Gene = CYP137 1 aa diff

           locus_tag = Mb3710c

 

>CYP137A2   Mycobacterium marinum MM5175

MPASAPSART PPALRRPPGL PAPRRLRTVF AAAYAVAYLV GGERRMLRLI RRYGPIMTMP

ILSLGDVAIV SDPALVKEVF TAPPDVLLGG EGVGPAAAIY GAGSMFVQEE PEHLRRRKLL

TPPLHGTALG RYVPIIEEST RAAMRDWPVD RPFELLGAAR ALMLDVIVKV IFGVDDPDEV

RRLGRPFERL LDLGVSEQLT VRYALRRAGA LRVWPQRARA YREIEDVVMP LIAQRRSDLG

RTEQRDILGL LISARGDDGE QLSDQEIRDD LITLMLAGHE TTATTLAWVF DLLLHHPDAL

RRVQEEAEGG TETFTTAVIN ETLRVRPPAP FTARVAARPF RLGGYLIDPG TRIVVHMIAI

NRNPDVYEQP NRFRPERFLG TRPQTYAWVP FGGGAKRCLG AAFSMRELVT VLHVLLREGQ

FTAVDEAPER IVRRSIMLAP RHGTRVRFRP RLQESV*

 

>CYP137A2P  Mycobacterium ulcerans

VPASAPSARTPPALRRPPGLPAPRRLRTVFAAAYAVAYGWWRAANAAIDPALRADHDDAH

PEPGRRGDRLGPGTGQRSLHRAARRAPGW*MLRLIRRYGPIMTMPILSLGDVAIVSDPAL

VKEVFTAPPDVLLGGEGVGPAAAIYGAGSMFVQEEPEHLRRRKLLTPPLHGTALGRYVPI

IEESTRAAMRDWPVDRPFELLGAARALMLDVIVKVIFGVDDPDEVRRLGRPFERLLDLGV

SEQLTVRYALRRAGALRVWPQRARAYREIEDVVMPLIAQRRSDLGRTEQRDILGLLISAR

GDDGEQLSDQEIRDDLITLMLAGHETTATTLAWVFDLLLHHPDALRRVQEEAEGGTETFT

TAVINETLRVRPPAPFTARVAARPFRLGGYLIDPGTRIVVHMIAINRNPDVYEQPNRFRP

ERFLGTRPQTYAWVPFGGGAKRCLGAAFSMRELVTVLHVLLREGQFTAVDEAPERIVRRS

IMLAPRHGTRVRFRPRLQESF

 

>CYP137A3   Mycobacterium vanbaalenii PYR-1

MAEHSPHESYRCEMVHIVRPPSLPAPPPLAPVFGGLYAAAFGMGGQAIVAQMVRRYGPVVALPVLGFGKV VAVADAALAKQVFTENPDVLLGGEGVGPAAAIYGPRSMFVLEEPGHLRRRRLLTPPLHGELLGSYVPIIE SSTRSAMATWPVGRPMRMLDAARELTLDVIVQVVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRR FGALRRWGRLSDANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRDDLITLVLA GHETTATTLSWLIDLLLHHPRALARVRAEAVSGDTGYTEAVIAETLRLRPAAPITGRMTTGPYRLGDYTL EPDTRIVLLLDVINRNPDTYPQPDEFRPERFLGSRPHPYAWIPFGGGVKRCIGAAFAMRELTTTLHTVLR EGELEPVSARPETPPLRAAPVLVPRDGTRVRFTPARPAASPRCADRTSTV

 

>CYP138A1    Mycobacterium tuberculosis

MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVR

RYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGD

DHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILR

AIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVID

KLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLG

WAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGE

WVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAA

FANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR

 

>CYP138A1    Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome 163556..164881

            Gene = CYP138 100% match

            locus_tag = Mb0141

 

>CYP138A2    Mycobacterium smegmatis

            66% to CYP138A1

MTATVERPESAIRAAQLPPVLPLPKTVQGLAFSVARRWVVKQAARRYGDV

VTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPNLSRMLGPGSVFAL

DGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAASWPDGQEFRTLEP

MMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRNYGR

LTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGS

SMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAATD

DNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAH

IQEREEEFSDPHRFDPQRFVGNRPGLGWLPYGGGTRRCVGAVFANIEMDV

VLRTILRHFVIETTTAPDEKVHPRGVAYTPASGGRVVMRRRREPLGA

 

>CYP138A3   Mycobacterium marinum MM0346

MNQAISDAPA VPAVKMAQAT RIPKLLQGLA FATSRRRMMD WLSRRNGDVF ALNVPIYGHM

VVVNDPQLAK QVFTASPEDL GNIQPNLSRM FGSGSVFGLD GDDHRRRRRL LAPPFHGKSM

KNYEIIIEQE TLRETANWPE GQLFPTLPSM MRITLNAILR AVFGADGAEL DELRRIIPPW

TTLGSRLASM PKPKRRYGRF SPWGRLAEYR RQYDVIIDRL IDQERSDPNF SDRTDVLALM

LRSTYDDGSR MSRKDIGDEL LALLAAGHET TASTLSWAFE RVTRHPELLA ALVAEAEDAG

GELRQATILE VQRARTVIDF AARHVYAPQY QLGQWMIPRG QSILVNIAQM HANPDIFPDP

QRFDPQRFIG GRPSTFGWIP FGGGTRRCVG AAFANMEMDV VLRTVLRNFT IEPTTAAGER

LFCRGVAYTP KNGGRIVVHR R*

 

>CYP138A3P  Mycobacterium ulcerans

MNQAISDAPAVPAVKMAQATRIPKLLQGLAFATSRRRMMDWLSRRNGDVFALNVPIYGYM

VVVNDPQLAKQVFTASPEDLGNIQPNLSRMFGSGSVFGLDGDDHRRRRGLLVPPFHGKSM

KNYEIIIEQETLRETANWPEGQLFPTLPSMMRTTLNAILRAVFGADGAELDELRRIIPPW

TTLGSRLASMPKPKRRYGRFSPWGRLAEYRRQYDVIIDRLIDQERSDPNFSIGPTCWP*V

LALMLRSTYDDGSRMSRKDIGDELLALLAAGHETTASTLSWAFERVTRHPDLLAALVAEA

EDAGGELRQATILEVQRARTVIDFAARHVYAPQYQLGQWMIPRGQSILVNIAQMHANPDI

FPDPQRFDPQRFIGGRPSTFGWIPFGGGTRRCVGAAFANMEMDVVLRTVLRNFTIEPTTA

AGERLFCRGVAYTPKNGGRIVVHRR

 

>CYP138A4   Mycobacterium marinum MM3976

MTELVAAAAV PPAVRLPPEF RMPKALQAIT YVALRRWLLL RLARRYGKVF SVNLPLYGHI

VVVGDCLLAK QVLATSPEEL GNIEPNLGRL FGPGSIFSLD GEEHRQRRRL LMPLFHGNLM

KSYESIIEDE TLREVANWPE GQSFPAMPAM AQITLGGILR ALFGPECAEL DELRRLVPPW

VTLGLRIALL PRPRRDYGRY SPWARLAEMR HQCEIVIEKL IEAARTGPNL AERTDVLALM

LRSCYDDGSA MSHNDIVDEL LTMMAAGHET TAATLTWAFE RLGRHPDVLA ALVEEADRGG

RALRQATILE VQRTRPAIDR VVRRVCSPYY RLGQWVLPQG YSVHLHIEQV QSDPEIFPDP

ERFDPHRHMG GKPSSLGWIP FGGGTRRCIG AALANLEIDV VLRTVLRNFT IEPNAAPDER

WHNRGIAFTP KDGGQIVVHR RH*

 

>CYP138A4P  Mycobacterium ulcerans

MTELVAAAAVPPAVRLPPEFRMPKALQAITYVALRRWLLLRLARRYGKVFSVNLPLYGHI

VVVGDSLLAKQVLATSPEELGNMEPNLGRLFGPGSIFSLDGEEHRQRRRLLMPLFHGNLM

KSYESIIEDETLREVANWPEGQSFPAMPAMAQITLGGILRALFGPECAELDELRRLVPPW

VTLGLRIALLPRPRRDYGRYSPWAGLAEMRHQCEIVIKKLIEAARTGPNLAERTDVLALM

LRSCYDDGSAMSHNDIVDEPLTMMAAGHETTAATLTWAFERLGRHPDVLAALVEGGRPGR

SRPPAGDDPGSPADQAGDRSSSSTRLLALLPARSMSSAPRVFGPPSYRTSSIRSRGLSRP

GALRSASPHGGASHRRSDGSHSVAGLAAASGLP+VVLRTVLQHFTIQPNAAPDERWHNRG

IAFTPKDGGQIVVHRRH

 

>CYP138A5   Mycobacterium vanbaalenii PYR-1

MSEATIAAHRSTADAESAPPRPVRLPPTPRIPKLLQGLGFSFSRQWTVAQIVRRYGDVFSMTLPVFGPTV MVADPALAKQLFMANTDDVGNIQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEET LREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTPHRTYGRFS PWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRSTYEDGSTMSRQDIGDELLTLLAAGHETT AATLGWAFERISRHPEVLAKLVAEAETDGNEYRQATILEIQRSRTVIDFAGRHVYAPTFELGEWVIPQGY SIVVAIGQVHKRAQDFDDPDRFDPQRYIGQRPPTFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVI

ETTAAPGEKMHSRGVAYTPKDGGRVVMRRR

 

>CYP138A6P   Mycobacterium leprae

1 NRVAREIVVEVIYGALFGAFEALSGLVPQDTVLGPMGRYSMAPSLIR

439 ITINVIMRAGFGSELDELRRLHPTAATL 522

    RWTVERQARCNHDIFMLDSRSTAERLRRRLHGTCMKNH 351

352 VRIFEAEPLWGLRTGLKASLLPHCRLINRITINVIMRAGFGSELDELRRLHPTAA 516

517 TLVGLF*LLSQHLGVLADPSSMGATMPGDDPAPALRQATIPG

638 LGVQWTRTVIDFAARRVYSSVYHLSEWAIPREDSILISIAQIYXXXXXXXXXXXX 766

795 DPRRYVEHKPSSFAWI 842

    PFSGGT 861

862 SRCVSICQDGDGMNVVLKMVLRYWIIDTTTAPGER*HLRGVVYTPRNGGR 1011

 

>CYP138B1   Mycobacterium marinum MM4430

MAEATTDPIQ LPPGPNASKL TQTLVYVFAK ARARTRLTNR YGSGYSLNLP KYGPTLVISD

PAMLKELFTS GNDLVTRPTT LGKLLGPGSI LSMIGVEHRQ RRKLMVPPFS GRRIDAYVKI

VEEEFLREAQ TWPEETEFES LQALVNITGS IVLRTILGAH GAIFEELQYL GPRTIVLAAR

MIALPEWLRR DLGPWSPWGK IQAARSRFDE LIAQLIAEAR ADPNFETRTD MLAMMLQARY

DDGSPITDAH ISDEMLTMIV AGHETTATTL AWAVERLRRS PSFVAQLVDE IDNGGTALMQ

ATVWEVQRTR PVLDFIARRV ETQLRLGPWV LPKGHMIVGD VWAAQHASSS FKDPERFDPT

RFADGPPESY AWIPFGGGIH RCIGAAFANM EMTTVLRTLL RKFELVPTDA PAEPIRSRGI

TNAPGHGGRI VVRSRPAGAR AAYASEDGHS AVAQSV*

 

>CYP138C1   Mycobacterium vanbaalenii PYR-1

MATATTDPVRLPPGPRIPKLIQGAAVLTQRYGAIAALGRRYGPTFTLNIPVFGETVVISDPVLVKDLFST HRDLVGRPQNNLGGDVLGPGSIFNLEGDALQARRKLLLPPFNGKSMRGYASITEEEAIREIRTWPEGVEF ETLEPMMRITLNTILRAVFGAEGEQLDELRELMPKAVEFGSKIALMPSIVRKDFGPWSPGGKFARYRKRM DELLNGLLNDARSDPNFTERNDVLSLLLQARYDDGSPMPDSFILDELLTMLVAGHETTSTQLAWTIERIR RHPQLLVRLTEEVDAGGNELLLATIAESQRTRPVLTAALRRARTRIRLGEWVIPEGDTILASTQLAMAAE SSFPDADKFNPDRFVGNPPNPFAWIPFGGGMMRCIGASFATMEMEVTLRALLREFTIEPTTEPDEKPHSR

GVTVTPGRNGRLVVHRREHKAARATDSVSVAESS

 

>CYP138C2   Mycobacterium flavescens PYR-GCK

MATATTDPVR LPPGPRFPKL IQGGAVLAFR YGSVAALGRR YGSTFTLQLP VFGETVVISD

PVLVKDLFST SRELVGRPQN NLGGDVLGPG SIFNLEGDEL LARRKLLLPP FNGKNMRAYE

DITEQEVIRE MQSWPEGVEF ETLEPMMRIT LNTILRAVFG AKGDELDELR VVIPAAVEFG

SKIALLPSVV RKDLGAWSPG GKFARYRRRM DEICTQLIAD ARSDPDFTDR GDVLSLLLQA

RYDNGDPIPD AFVVDELLTM LVAGHETTST QLAWTIERIR RHPDLLARLS DEVDAGGNEL

MAATIAESQR TRPVLTAALR RARTRIRLGE WVIPEGDTIM ASTQLAMAAE QSFPDAEKFN

PDRFVGNPPN PFAWIPFGGG MMRCIGASFA TMEMDVTLRT MLREFRLEPT DEPDEKPHSR

GVTVTPGRGG RAVVRRRRTP ASGDANSVSV AETSR

 

>CYP139A1    Mycobacterium tuberculosis

mrtyrtvRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFAN

ADAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNID

TVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQ

VMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTT

LSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAAD

DLSALTYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPE

IWPEPTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR

AMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ"

 

>CYP139A1    Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome complement(1877656..1878948)

            Gene = CYP139 start codon differs by 6 aa

            locus_tag = Mb1694c

 

>CYP139A2P   Mycobacterium leprae

GAAVATTSMTVILARLASRTRLHLLAHYTHRVRARNFAALIP*LSLTVEVINSMPTQ

 

>CYP139A3   Mycobacterium marinum MM2475

MSTYRTVPYR PGEALLALYR RRGAFIDAGV GRHGFVYLLG PEANRFVFAN ADAFSWRETF

ESLVPVDGPT ALIVSDGEDH RRRRSIVAPG LRHRSVQDYV ATMVSTIDNV IDSWRPGQPL

DIYQEFRCAV RRSTTESLFG PRLASHSDYL GRQLQPLIDL THRLPQVMQL QQRLNSPGWR

RAMAARTRID ELIDAEIANA RAEPSPDDRM LTALINGRSE EGCALSDNEI RDSIVSLIAA

GYETTSGALA WATYSLLTLP GAWETAAREV ARVLGGTAPS AETLGALTYL NGVVHETLRL

YSPGVVSARR LIRDLWFDGH RINSGRLLIF SAYVTHRIPE VWPNPTQFLP QRWDPAAPDY

RKPAPHEFIP FSGGLHRCIG AVMATTELVV LLARLVARTR LRLPAQRIRA ANFAALAPKP

GLRVEFVDSV PAQ*

 

>CYP139A3P  Mycobacterium ulcerans

VPYRPGEALLALYRRRGAFIDAGVGRHGFVYLLGPEANRFVFANADAFSWRETFESLVPV

DGPTALIVSDGEDHRRLCSTVAPGLRHRSVQDYVATMVSTIDNVIDSWRPGQPLDIYQEF

RCAVRRSTTESLFGPRLASHLDYLGRQLQPLIDLTHRLPQVMQLQQRLNSPGWRRAMAAR

TRIDELIDAEIANARAEPSPDDRMLTALINGRSEEGCALSDTRFATPSFRSSRPATRPPA

QRWRGPPTPCSRCPAPGRRRPARLPGCSAAPRPAPRPSALSPTSMALCTKRFGSTHREWS

RRAG*LRGAPQHDREPVRPTAGLPFGLSGPTTAASDRPDPPVAPGDATTAAAQLTGLAAG

DGRAHPHRRTDRCRNRQRSRGAQPRRPHADRTDQRPFRRRLRVERHEIRDSIVSLIAAGY

ETTSAALAWATYTLLTLPGAWETAAREVARVLGGTAPSAETLGALTYLNGVVHETLRLYS

PGVVSARRLIRDLWFDGHRINSGRLLIFSAYVTHRIPEVWPNPTQFLPQRWDPAAPDYRK

PAPHEFIPFSGGLHRCIGAVMATTELVLLARLVARTRLRLPAQRIRAANFAALAPKPGLR

VEFVDSVPAQ

 

>CYP140A1    Mycobacterium tuberculosis

MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPF

YDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQ

LHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIV

DVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRG

FDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV

NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR

IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGE

VGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP

 

>CYP140A1    Mycobacterium bovis subsp. bovis AF2122/97,

MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPF

YDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQ

LHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIV

DVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRG

FDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV

NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR

IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGE

VGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP

 

>CYP140A2    Mycobacterium smegmatis

MRERLRWMALHGFVRSMATLGLRRGDPQARLIADPVVRADPTTFADQMRKQGPVIRG

RVVLLTFDHAVAFDLLRSDDFQVSQLGANLPKPLRWIADKTNPGLLHPIE

PPSLLSIEPPDHTRMRKLVSSVFTTRAVATLRERVEQTAHELLDGLEAES

GVVDIVERYCAQLPVAVIGDILGVPEPDRPNILRYGELGAPSLDIGLSWS

QYQQVNEGIIGFETWLNRHLRTLRRDPGDDLLSQIITASESGATGEPLTD

RELKALAGLVLAAGFETTVNLLGNGIRMLLDHREHLETLAARPDVWPNAV

EEILRLDSPVQMTARAAVRDVDVAGTAVGRGELVVLHIAGANRDPKVFDD

PHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRAFFDRFPDARL

AGDPVRRDTRVLRGWSTLPIALGKARAAVGS

 

>CYP140A3P  Mycobacterium leprae TN

VRQRLHWFAQYGFIRGIAATHH

RRSDPLARLDIALAIKANPVP

YCHKPRPRRPLVQSRISYLTANRAITHELLQSEDFHVFWLNVTLPAPSHWL

RRRTGYRTSSQYNL

LHPLLAIQ*AYHIHYRKTVSPLFAPKAVATLRDRIEQTTLALLDQLAHQHDVVDVVNRY

CSQLPVAVISDILGYP

VPDRDRSHILKFGELVAPSLDVELT*Q*YQQA*REVAGFNFWL

LKHLPQLQRTPGDNLVRHLSH*EDNKPTEISLSKSKLQAISG

GLVLATGGETTVNLLGRGI

LLLDTPEHMVMLQACPEPGHKRG*EILRLDSPIQMAARVARKDVDLAGSTIKRSQVVVLY

FGRSQPGPVRLCRSR*VQHRTPQCGKESRIFR*QEFCLENALTRAYNAVGLRAFFDHLP*

TRAAGTRSRLDTRVLRGWSTLPIALGPTRSMVS

 

>CYP140A4   Mycobacterium avium subsp. paratuberculosis

GAAARQSRPVGPRRSRRSCDRQPGPDDRAHAPPATSTSAPAMVG

LVPRRARNRDPKVFSDPTTFDVTRPNAREHLAFASGIHACLGAALARIEGATCARSFE

NFPDRSSRARNGGR

 

>CYP140A5   Mycobacterium marinum MM2768

MKDKLHWFAM HGVIRGMANI GLRRGELEAR LIADPAVAAN PGPFHDELRR HGRMVRTRVN

YLTVDYQLAH DVLRSDDFHT ISFGENLPGP LRWLERRTRD EQLHPLRPPS LLAVEPPDHT

RYRKTVSAVF TSRAVAALRD RVEQTANSLL DQLAQRPGVV DVVGQYCSQL PIMVISEILG

VPEQDRGRVL EYGELAAPSL DIGVPYRQYR RIQQGITGFN SWLTAHLEQL RRNPGDDLMS

QLIRVAESGD AGTYLDESEL RAVAGLVLVA GFETTVNLLG NGIRMLLDAP EQLETLRQRP

ELWPNAVEEI LRLDSPVQLT ARVARTDVEI ASWPINRGEM VVAYLAGANR DPAVFPNPHR

FDVERANAGR HLAFSTGRHF CLGAALARAE GEVGLRTFFE RFPDVRAAGA GSRRDTRVLR

GWSTLPVTLG PARALAAS*

 

>CYP140A5   Mycobacterium ulcerans

VKDKLHWFAMHGVIRGMANIGLRRGELEARLIADPAVAANPGPFHDELRRHGRMVRTRVN

YLTVDYQLAHDVLRSDDFHTISFGENLPGPLRWLERRTRDEQLHPLRPPSLLAVEPPDHT

RYRKTVSAVFTSRAVAALRDRVEQTANSLLDQLAQRPGVVDVVGQYCSQLPIMVISEILG

VPEQDRGRVLEYGELAAPSLDIGVTYRQYRRIQQGITGFNSWLTAHLEQLRRNPGDDLMS

QLIRVAESGDAGTYLDKSELRAIAGLVLVAGFETTVNLLGNGIRMLLDAPEQLETLRQRP

ELWPNAVEEILRLDSPVQLTARVARTDVEIASWPINRGEMVVAYLAGANRDPAVFPNPHR

FDVERANAGRHLAFSTGRHFCLGAALARAEGEVGLRTFFERFPDVRAAGAGSRRDTRVLR

GWSTLPVTLGPARALAAS

 

>CYP140A6   Mycobacterium vanbaalenii PYR-1

MAADLQQRIRWLALHGVIRGLSKVAVRRGQDPQARLIADPAVRADPAAFADELRGRGPVIRCRAVLMTVD HQVVNEILRSDDFRVSSLGAGLPKPLQWINRKTHPGLLHPIEPPSLLSIEPPDHTRCRKLVSSVFTTRAV AALRERVQQTANDLLDDLERESGVVDIVERYCSQLPVAVISDILGVPERDRRHILHFGELGAPSLDIGLS WRQYTQVHEGLVGFNEWLGGHMDELRRNPGDDLMSQLIQASQAADEGSRLTDRELQATAGLVLAAGFETT VNLLGNGIRMLLETPGHLETLAARPELWPNAVEEILRLDSPVQMSARFARRDVTVGGTEIKRGELVILHL AGANRDPEVFTDPHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRTFFERYPDARLAGQGSRRD TRVLRGWSTLPITLGTARAALGS

 

>CYP140A7    Mycobacterium ulcerans

MVMANPAPFCDELRAIGPVVSSYGTHLV

VSHAIAHELLRSEDFEVVSLGSNLPAPMRWLERRTRDDTPHLLLPPSLLAVEPPNHTRYR

KAVSSVFTPKAVAGLRDHVEETASALLDQLTDQASAVDIIARYCSQLPVAVICDILGVPS

RDRNRVLKFGQLAGPCLDFGLTWRQHQQVRQGLQGLHFWITEHLEELRSNPGDDLMSQMI

HASENGSSETHLHATEVRMIGLVLGASFATTMDLLGNGIQVLLDAPELRDALSQRPQLWP

NAVEEILRLEPPVQLAGRMARKDTEVAGTAIKRGQLVAIYLGAVNRDPSVFADPHRFDIT

RANANRHLAFSGGRHFCLGAALARVEGEVGLRMLFERFPDVRAAGPGNRRDTRTLRGWSQ

LPVQLGAARSMAIR*

 

>CYP140B1    Mycobacterium vanbaalenii PYR-1

MGQHAGRQAGPGGAGRPVGRSGARRSGGGQPWAARAAGRRRAQVGAGAGPGSGRAAHGRHLRRPSPRQPD RRMRSRPAVWLRWATVHGVPRAFLTVRARRGEPLARLILGRGDRLALIEEIRAAGPLMRTPVVWATADYD VCRTVLRDNDFGVADPSETGLPDALLGLIRRVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFTPRSIA ALDTRIGELTAELLDDLGRRREVDLIADYAAQLPAAVISRMLGVPDEDRARILGWGETGAALLDIGIGWR PFRAAIDGLVDVDTHLGAHFRRLHQNGADGTPFSSLALDGSLSGRELISNAALLVGAGVETTVNLIGNGI AALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTARTAHRDTEIAGVGIRKGAVIVMLLGGANRDPK VFDRPQTFDITRANARDHLAFASGIHVCLGAALARIEGATALRELFTRYPDLHLTAPAEPRDLVTLHGYR HLPVRLGRAATATRRAS

 

>CYP141A1    Mycobacterium tuberculosis

MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAW

LVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQG

LNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH

ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQS

TMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIV

RFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPN

EHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIK

ELLVTWPT

 

>CYP141A1P   Mycobacterium bovis subsp. bovis AF2122/97,

IAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT*

 

>CYP142A1    Mycobacterium tuberculosis

MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAAS

TYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK

EASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLV

TFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDD

ELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAP

VKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFG

FGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFT

PSPPLG

 

>CYP142A1aP  Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome complement(3898119..3898736)

            gene = CYP142A1a aa 1-197 100%

            locus_tag = Mb3548c

            In Mycobacterium bovis, a frameshift due to a single base

            deletion (c-*) splits CYP142 into 2 parts (pseudogene)

 

>CYP142A1bP  Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome complement(3897541..3898122)

            gene = CYP142A1b aa 207-end 100%

            locus_tag = Mb3547c

            In Mycobacterium bovis, a frameshift due to a single base

            deletion (c-*) splits CYP142 into 2 parts (pseudogene)

 

>CYP142A2    Mycobacterium smegmatis

MTQMLTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQ

AVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRK

RVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPT

ERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEP

TDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLL

RHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRA

GEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLAR

LELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA

 

>CYP142A3   Mycobacterium marinum MM5003

MTKPLIKPDV DLTDGNFYAS RQAREAYRWM RANQPVFRDR NGLAAASTYQ AVIDAERQPE

LFSNAGGIRP DQDALPMMID MDDPAHLLRR KLVNAGFTRK RVKDKERSIA QLCDTLIDAV

CERGECDFVR DLAAPLPMAV IGDMLGVLPE QREMFLRWSD DLVTFLSSHV SQEDFQVTID

AFAAYNDFTR ATIAARRAEP TDDLVSVLVS SEVDGERLSD DELVMETLLI LIGGDETTRH

TLSGGSEQLL RNRDQWDLLQ SDRELLPGAI EEMLRWTAPV KNMCRMLTAD TEFHGTALSE

GEKIMLLFES ANFDEAVFTD PEKFDIQRNP NSHLAFGFGT HFCMGNQLAR LELSLMTARV

VQRLPDLRLA DQDSRLPLRP ANFVSGLESM PVVFTPSRPL S*

 

>CYP142A3   Mycobacterium ulcerans

MAMTKPLIKPDVDLTDGNFYASRQAREAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQ

PELFSNAGGIRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDKEHSIAQLCDTLID

AVCERGECDFVRDLAAPLPMAVIGDMLGVLPEQREMFLRWSDDLVTFLSSQVSQEDFQVT

IDAFAAYNDFTRATIAARRAEPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETT

RHTLSGGSEQLLRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTAL

SKGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLARLELSLMTA

RVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRPLR

 

>CYP142A4   Mycobacterium vanbaalenii PYR-1

MTSTLPALDVDLADGNFYADGRAAREAYKWMRANQPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIR PDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDKVPSIENLCDTLIDAVCERGECDFVRDIAAPLPMA VIGDMLGVLPDERDMLLKWSDDLVCGLSSTVDEQTIQKLMDTFAAYTAFTTEVIADRRANPRDDLFSVLV NAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHQDQWRQAVADPELLPGAIEEMLRWTSP VKNMCRTLTADTEFHGTSLKAGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA RLELRLMLTKILQRLPDLRLADESMLPLRPANFVSGLESMPVVFTPTAPVGA

 

>CYP142A5    Rhodococcus sp. RHA1 Rha05910

MRRSASMTNRPDFDLIDGRFYSGELGDPRQAYAWMRAHEPVYRADGILGAASYEAVLAAERDPELFSNAGGIRPGLGPLPQMIDMDDPQHLQHRRLVNAGFTRKQVEAKIGRIREICDHLIDAACDKDEVDFVRDLAAPLPMAVVGDMLGMRPEERDTFLQWSDDLMNALGSNATPEELQAQANAYLAFNEFTLRTIEERRQNPTDDLTSILVHSEIDGHRLSDPDIVGETLLILIGGDETTRHVLSGGMEQLMRHPDQHQRLVNDPDGIPAAVEEMLRWSSPIKNMCRTVTRDVEFFGTDLRQGEKMMLLFESANFDDAVFDSPEVFDIERSPNPHVAFGFGTHFCLGNQFARLEAKIMFEQLLSRLPDMVLVDDGPLRRRPANFVSGLEEMPVKL

 

>CYP142B1    Mycobacterium vanbaalenii PYR-1

MTTAVPTHRDIDLSDRNFWARPHEERDAAFAVLRRENPVPWSRPADSDLLPPEQNLKGFWSLTKHEDIRY ASRHPEIFSSAEGITVEDFPVEIRMMSQSFIAMDAPRHTQLRGITLDAFKPRNMLRLQDWIQGHARDLIS EISHLGEGDFVDLVSVKLPGRIFGSFFGLPPGELHEKTINAAQRTLGWTDPEVRGDLTAVELFVGAVMDL HETVTTLLPERRANPGDDLLSWMVQAEFDGEKMTDDELKAFFTLLAVAANDTTRHASAHAILAFSQFPDQ RDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQDVTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKF DIARNPNPHIAFGGGGPHFCLGAALARTMLRSLLTEVYTRIPDISAPEPRYQVANFINGINSLPATWTPERR

 

>CYP142B2    Mycobacterium sp. JLS

MTTVFPETTH GDIDLSAREF WAKPPVERDA AFAVLRRENP VAWSRPADSD LLPPEQNLKG

FWSLTKHEDI RYASRHPEIF SSAQGITMED FPHEILMMSQ SFIAMDAPRH TQLRGITLDA

FKPRNMRRLQ GWVQEHARDL ISEMSHLGEG DFVELVSVKL PGRIFGSFFG LPPGEIHEKT

IDAAQRTLGW TDPDVRGDRT ALELFAGAVM DLHETVTTLL PERRANPGDD LLSWMVQAEF

DGVKMTDDEL KAFFTLLAVA ANDTTRHASA QAIYAFSQFP DQRDLLVADV EGRVDSAVEE

ALRWASPLIH MRRTATQDVT VRGAEIKAGD KVVLWYSSAN RDEDVFDDPF TFDIERNPNP

HLAFGGGGPH FCLGAALART MLRSLLTEVY TRIPDIHAPE PKFQVANFIN GINSLPATWT

PERR

 

>CYP143A1    Mycobacterium tuberculosis

MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFM

NGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYF

SPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRL

IGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLS

EIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLE

PSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWG

FGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS

 

>CYP143A1    Mycobacterium bovis subsp. bovis AF2122/97,

MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFM

NGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYF

SPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRL

IGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLS

EIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLE

PSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWG

FGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS

 

>CYP143A2P   Mycobacterium leprae

1 MSTSAKANPTHFTYCSLNYSALSMITDRGVIWKTLXX 105

 113 AKPVVFMNG*YYLNVSRKCILHTTSITKGFSSREAXXX 217

 225 PGNALPVLPXXXXXXXXXXXXXXXXXXX 251

 278 SLNNLNKALPALRTYTVTMANAITSRGEW 364

 366 EAMTDFANX 389

 391 LFPLQLFLVL*GLXX 429

 434 AQDRDHLIALLKDVVIGMSDKPFLSQADIADQGELCEYLVDTIAERKQNPA 586

 585 PDVLSQVLIGEDPLSEIKVLDLESL 659

 659 MLILAELDTVTATVGFSLLQPACRQQLRTMLRDKPKQIRILIED 790

 792 ILQLEPPAQITPYITTEFVNVDGMTLSPGSRVRLC 896

     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX

 993 GSHLARLKLTLAVDEWLINI 1052

     XXXXXXXXXXXXXXXXXX

1116 LFALKALALHW 1148

 

>CYP143A3   Mycobacterium marinum MM2631

MSAPRDERDI PHFVYAELPM ATDRGRGWAT LRDAGPVVIG DGFYYLTRRD DVLDALRHPE

VFSSKRAFDI LGSPLPLVPL AFDPPEHTRF RKVLQPFFSP HALAAMLPSL QAQAIEIIDA

IAAGSQCEVI TELAIPYPSQ VFLTLFGLSL ADRDRLIRWK DAIIALGLLA SLDDADLTPA

LELTSYLVDA IAAHRRHPGT DILSQVLLGD DPLDDSEALG LSYVFVLAGL DTVTSAIGAA

LLELARRPQL RQLLRENHGQ IAVFVDEIVR LEPPAPVVPR VTTREVNIAG AKIPAGSRVW

LCLGAINRDG SDATSVNDVV MDGKVHKHWG FGGGTHRCLG SHLARMELSL VISEWLRRIP

QFELACGYTP EIDWPSATLG LSTLTLQFTS *

 

>CYP143A3   Mycobacterium ulcerans

MSAPRDERDIPHFVYAELPMATDRGRGWATLRDAGPVVIGDGFYYLTRRDDVLDALRHPE

VFSSKRAFDILGSPLPLVPLAFDPPEHTRFRKVLQPFFSPHALAAMLPSLQAQAIEIIDA

IAAGSQCEVITKLAIPYPSQVFLTLFGLSLADRDRLIRWKDAIIALGLLASLDDADLTPA

LELTSYLVDAIAAHRRHPGTDILSQVLLGDDPLDDSEALGLSYVFVLAGLDTVTSAIGAA

LLELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRVTTREVNIAGAKIPAGSRVW

LCLGAINRDGSDATSVNDVVMDGKVHKHWDFGGGTHRCLGSHLARMELSLVISEWLCRIP

QFELACGYTPEIDWPSATLGLSTLPLQFTS

 

>CYP143A4   Mycobacterium marinum MM2666

MSTPGEGSAS SFYLPRLEYS TLPLAADRAV GWNTLRDAGP VVFMNGHYYL TRREDVLAAL

RNPKIFSSRI LQPPGNPLPV VPLAFDPPEH TRYRKALQPY FSPHALGKSR PVLERHAAEM

IAGFAGRGEC DAMAEFARLY PFQVFLDLYG LPLQDRDRVI AWKDAIIGDK LYLTREELEV

GQLELLEYLN NAIQQRRQNP GSDMLSQVMT GPGEFTDLEL LGMSHLLILA GLDTVTAAIG

FSLLELARRP QLRTQLRDNP KEIRVFIEEI VRLEPSAPVA PRITTDFVNV GGMTLPPGSQ

VRLCMAAVNR DGSDAMSTNE LVMDGKVHRH WGFGGGPHRC LGSHLARIEL TVIVAEWLKQ

LPDFELAPDY SPEIAFPSKT FALKSLPLRW A*

 

>CYP143A4   Mycobacterium ulcerans

MSTPGEGSASSFYLPRLEYSTLPLSADRAVGWNTLRDAGPVVFMNGHYYLTRREDVLAAL

RNPKIFSSRILQPPGNPLPVVPLAFDPPEHTRYRKALQPYFSPHALGKSRPVLERHAAEM

IAGFAGRGECDAMAEFARLYPFQVFLDLYGLPLQDRDRVIAWKDAIIGDKLYLTREELEV

GQLELLEYLNNAIQQRRQNPGSDMLSQVMTGPGEFTDLELLGMSHLLILAGLDTVTAAIG

FSLLELARRPQLRTQLRDNPKEIRVFIEEIVRLEPSAPVAPRITTDFVNVGGMTLPPGSQ

VRLCMAAVNRDGSDAMSTNELVMDGKVHRHWGFGGGPHRCLGSHLARIELTVIVAEWLKQ

LPDFELAPDYSPEIAFPSKTFALKSLPLRWA

 

>CYP143A5   Mycobacterium vanbaalenii PYR-1

MSALPHVLYGDLPMAADRGAGWATLREFGPVAYGDGWYYLTRRDDVLAALRNPEVFSSRIAYDDMISPVP LVPLGFDPPEHTRYRRILHPFFSPQALGVLLPSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLTLF GLPLQDRERLIAWKDAIIAFSLTNDPTSVDLTPAVELYGYLTEAVARQREKPREGILSHLLHGDEQLTDN EAVGLSLVFVLAGLDTVTSTIGATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREV TVAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLDGKLHKHWGFGGGPHRCLGSHLARMELRLVVTEWL SRIPDFELAPGYVPEITWPSATCTLPTLPLILTRKTP

 

>CYP143B1 Frankia alni ACN14a

MSAGEAQPLTFEDLPVRDDRDAAWRLIRERGGIVQLEPDVALTDHTLVEAAFRNPAVFSSRQAFDSLGSP

LPLVPIAFDPPEHARYRHILQPFFSPRSIRPLEPELRRQLAELIAPLPARGACDFVADVASVFPVQAFLT

FFGLPLDMRDQFVAWKDAILALSDPSGAISTDEADLRHAGELFTYLSELVAARRGVPGPDVLSELLCLDG

DDALTDAEVIGLCFLFVLAGLDTVTDALGFGMERLARNPDRRQEIVDDPGLVPAAVEELLRLDPPAPFVP

RITTAQTELGGRTLPAGTRVTAYIAACNRDEARYPDPYGVDFHRGDNPHASFGVGVHRCLGSHLARLEMR

LVYEEWHRLIPHYDIAPGFAPTVKFPRGTVGLEALPLVLTPGASR

 

>CYP143B2 Frankia alni ACN14a

MTHKRDMRHSASHAWNESWVTRRAGERVEGTAMTDDRNNEKVTLSNLPIARDRDAAWRQLREHGRTVLLD

GGLAATDVETVETVLRQPAIFSSKKAFDVLGSPLPLVPIAFDPPDQTRYRRILQPFFSPRAIRPLEDELR

RQIVEIVEPLVRRGSCEYVSEVAGIFPVQVFLTLFGLPLEMRDQFIEWKDAILGLSDPSGNTALDEAATE

AAMATALGLFSYLADLVPARRGVAGDDVLSQLLCLEGDEALTDEEAVGLCFLFVLAGLDTVVDALSFGTD

RLIRNPDRRREIVDDPALIPAAIEELLRLDPPAPFVPRVTTEQTVLDGRTLPAGTRVTTNLAAANRDPAR

HPDPYTVNFHRGESPHLSFGAGVHRCLGSHLARLEMRLVFEEWHRLIPDYDLAPGASPQVKWPRGTLGLD

ALPLVFPASAPAAGAGGQAS

 

>CYP143C1 SBI_7215 Streptomyces bingchengensis

51% to CYP143B2 Frankia alni ACN14a 

MTSVDSDTVHVVRDLPVAERRDDAWRMLMARPEPAPMDNGLAVTSLAAVK

AVLKEPNRFSAKKAFDAVETGYPLIPLAFDPPEQTHYRRILQPFFGPRRI

RALEESLRAQAIDLVEAVKARGGCDFVADIAVPFPAQALLTLLGLPLADR

DRFIESKNAALELTADAAGELTLTDEERAARVEQTMALGNYLGELIQTRR

AQPGDDILSEILAIDGDDHLSDTEAMGVCLMLVLAGLETVTDALSLAMER

LATHPGRRRELVEDPSLVPAAVEELLRLDPPAPFLPRVTTEDVEIAGCPV

PAGTLVNTHLTTANRDETCWPRPHDIDFHRPDNPHTSFGVGVHRCLGTHL

ARLEMQLLFEEWHRRIPEYAIAEGTSPRARLVRANIGMESLRLTIPTA

 

>CYP144A1    Mycobacterium tuberculosis

MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAE

SVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAE

GTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV

DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLV

AAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGG

ESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTL

DGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALAR

LEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ

 

>CYP144A1    Mycobacterium bovis subsp. bovis AF2122/97,

            NC_002945 complete genome 2001114..2002418

            Gene = CYP144 1 aa diff

            locus_tag = Mb1806

 

>CYP144A1P   Rhodococcus sp. RHA1 Rha02971