News Archives Up To October 21, 2014
These pages change frequently.The sequence guru at work
Royal Society Publishing has just published Cytochrome P450 and its impact on planet Earth, compiled and edited by David R Nelson. This content can be accessed at
http://bit.ly/YKdQVL A print version is also available at the special price of 35 pounds. You can order online via the above web page (enter special code TB 1612 when prompted) or, alternatively you can contact debbie.vaughan@royalsociety.org.
The 10th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
will be held in Woods Hole, Massachusetts, USA Oct. 3-7, 2010.A Link to the website
A new Cytochrome P450 Expression Database using Arabidopsis:
The 9th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
will be held in Nice, France June 8-12, 2008.
A Link to the website
MDO2008, The 17th International Symposium on Microsomes and Drug Oxidations
will be held July 6 to 10, 2008, at Saratoga Springs, NY, USA.
A link to a figure showing the distribution of plant P450 families over plant phylogeny
A link to a figure showing the distribution of plant P450 families over plant phylogeny
The 8th International Symposium on Cytochrome P450 Biodiversity and Biotechnology
was held in Swansea, Wales UK July 23-27 2006.A Link to the website.
MDO2006, 16th International Symposium on Microsomes and Drug Oxidations Will be held 3-7 September 2006, Budapest Hungary.
A Link to the website.
I have counted the number of named cytochrome P450s as of May 28, 2006.
There are Animals = 2255, Plants = 1918, Bacteria = 629, Fungi = 1001,
Lower eukaryotes = 205 sequences named. That is a total of 6008 different sequences.
for a list of these sequences see P450 Stats Page
A BLAST server has been set up on a RedHat Linux machine to allow blast
searching of selected P450 sets. There are 27 P450 sets to choose from. Only BLASTP or BLASTX work since this is a protein database. The server address is
http://www.p450.unizulu.ac.za/
THE CRYSTAL STRUCTURE OF CYP3A4, THE MOST PROLIFIC HUMAN DRUG METABOLISING
P450, HAS BEEN SOLVED BY ASTEX. SEE THE ASTEX PRESS RELEASE
- A link to Comparative genomics of rice and Arabidopsis. Analysis of 727 Cytochrome P450 genes and pseudogenes from a monocot and a dicot. Plant Physiology 135, 756-772 2004
- A link to Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes Pharmacogenetics 14, 1-18 2004
- A pdf version of Cytochrome P450 and the Individuality of Species. Archives Biochem. Biophys. 369, 1-10 1999
- A pdf version of Comparison of P450s from Human and Fugu. Archives Biochem. Biophys. 409, 18-24 2003
- A pdf version of Metazoan Cytochrome P450 Evolution. Comparative Biochem. Physiol. Part C 121, 15-22 1998
- A pdf version of On the Topology of Vertebrate Cytochrome P450 Proteins. JBC 263, 6038-6050 1988
- A link to P450 functions in plants an extensive listing with references.
From the Plant Biotechnology Institute, National Research Council,
Saskatoon, Saskatchewan CANADA - A link to an NPR story on drug interactions and CYP2D6
- A link to an essay in in-cites.com
- A link to my talk given in Los Angeles August 21, 2002
- A link to my talk given in Sapporo July 26, 2002
- A link to our bioinformatics course Jan. to May 2008
- A link to our old bioinformatics course Jan. to May 2002
- A set of links to this P450 homepage
- A description of P450 written for the PIR database
- A collection of mouse P450 sequences
- Link to The Molecular History of Eukaryotic Life Project Announcement
- Link to La Grande Motte P450 meeting in France September 11-15, 2001
- P450 family count
- Discussions on bioinformatics with Archakovs group
- Shameless speculation on P450 evolution in vertebrates
- A link to the Bioinformatics course I am teaching
- The Drosophila P450 Site at INRA Antibes, France
- The Arabidopsis P450 Site in Denmark
- Link to
Biologically Reactive Intermediates Meeting PARIS; July 16-20, 2000 - Plant P450s overlayed on plant taxonomy
- A note on plant P450 evolution
- Zea mays ESTs with P450s 39 P450 containing ESTs from Zea mays have been translated and sorted by family
- A note on Cytochrome P450 Evolution in yeast and early eukaryotes
- A commentary on my recent paper Metazoan Cytochrome P450 Evolution
- A higher order nomenclature for P450s: Clans
- An historical list of P450 name changes
A table of P450 accession numbers, (60k)
This is a list of all known cytochrome P450 accession numbers from PIR 44 (4/12/95)
SwissProt 31 (3/20/95) and GenBank 89 (6/9/95).
The following list is a familycount, (2k) This is a brief listing of the breakdown
of the 477 sequences in the alignment, how many families, subfamilies, how many plant familes, mammalian families etc.
The number of genes in a given species is listed here last modified Dec. 3, 1998
The distribution of P450s in each family between major biological classes (mammals,
fish, birds ) is given here (3k).
A midwest P450 Symposium server.
A European P450 WWW Server
Kirill Degtiarenko has also set up a cytochrome P450 WWW server in Trieste, Italy. This server has features not
included here, such as hyperlinks to the database entries for Genbank and SwissProt accession numbers. He has some
bibliographic
information that is different from the file maintained here. Some additional types ofsequences are also included, such as NADPH cytochrome P450 reductases and
NO synthases. To connect to Kirill’s server click here.
The larger files of the alignments, the bibliography and the accession number table
will be posted on Kirill Degtiarenko’s server to help those having difficulty in downloading these files from the UK and Europe. I can see from the usage log that many
of you have not been able to get these larger files intact.
A Protein Family Classification Server
MIPS (Martinsreid Institute for Protein Sequences) has a server that has sorted families
and superfamilies of proteins. These families are listed with their member’s PIR
accession numbers, and alignments made by pileup can be obtained for the families.
The superfamily number for P450s is 0027.0 and this can be connected directly by
clicking here.
The accession number table in my server has all the PIR accession numbers in the
MIPS server, but they are hyperlinked there, so you can get the sequence entry
directly. The URL for the more general section of this server is here.
For an equivalency table of the MIPS family numbers and the P450 nomenclature click here
For an obituary of Ryo Sato by Ron Estabrook click here