Comprehensive Bacterial P450s

CYP51B1 Mycobacterium tuberculosis (Actinobacteria) Rv0764c

MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ
LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN
AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ
LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT
DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR
DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV
QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH
RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG
V

CYP51B1 Mycobacterium marinum MM4932

MTTAIVPRVS GGEEEHGHLE EFRTDPIGLM QRVRDECGDV GWFQLANKHV VLLSGAKANE
FFFRSSDEEL DQAEAYPFMT PIFGKGVVFD ASPERRKEML HNSALRGEHM KGHATTIERE
VHRMIENWGQ EGEIDLLEFF AELTIYTSTS CLIGTKFRNQ LDSRFAHFYH ELERGTDPLC
YVDPYLPIES FRRRDEARKG LVALVQDIMH QRVANPPTDK RDRDMLDVLV SITDEQGNPR
FCADEVTGMF ISLMFAGHHT SSGTSAWTLI ELLRHPDAYA AVIDELDELY ADGQPVSFHA
LRQIPRLENV LKETLRLHPP LIILMRVAKG EFQVEGYPIH EGELVAASPA ISNRIAEDFP
DPDEFVPERY QEPRQEDLIN RWTWIPFGAG RHRCVGAAFA TMQIKAIFSV LLREYEFEMA
QPADSYRNDH SKMVVQLARP ARVRYRRRKM SDNRGH*

CYP51B1 Mycobacterium ulcerans

MTTAIVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLANKHVVLLSGAKANE
FFFRSSDEELDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEHMKGHATTIERE
VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCHELERGTDPLC
YVDPYLPIESFRRRDEARKGLVALVQDIMHQRVANPPTDKRDRDMLDVLVSITDEQGNPR
FCTDEVTGMFISLMFAGHHTSSGTSAWTLIELLRHPDAYAAVIDELDELYADGQLVSFHA
LRQIPRLENVLKETLRLHPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFP
DPDEFVPERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEFEMA
QPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH

CYP51B1 Mycobacterium bovis subsp. bovis AF2122/97 (Actinobacteria)

MSAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQ
LAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMTPIFGEGVVFDASPERRKEMLHN
AALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQ
LDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNGRIANPPT
DKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHR
DAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEV
QGHRIHEGDLVAASPAISNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRH
RCVGAAFAIMQIKAIFSVLLREYEFEMAQPPESYRNDHSKMVVQLAQPACVRYRRRTG
V

CYP51B1 Mycobacterium avium (Actinobacteria)

TSTVVPRVSGGEEEHGHLEEFRTDPIGLMQRVRDECGDVGWFQLVDKHVILLSGAQANEF 3021539
3021540 FFRSADEDLDQAEAYPFMTPIFGKGVVFDASPERRKEMLHNSALRGEQMKGHASTIEGEV 3021719
3021720 KKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYHDLERGTDPLCY 3021899
3021900 VDPYLPIESFKRRDEARVKLVALVQEIMDQRLANPPKDKADRDMLDVLVSIKDEDGKPRF 3022079
3022080 SADEITGMFISLMFAGHHTSSGTSAWTLIELIRHPDVYAEVLAELEELYADGQEVSFHAL 3022259
3022260 RSIPKLDNVVKETLRLHPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPD 3022439
3022440 PDAFKPDRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDFEMAQ 3022619
3022620 PADSYRNDHSKMVVQLARPAKVRYRKR 3022700

CYP51B1 Mycobacterium smegmatis (Actinobacteria)

VPRVSGGEEEHGHLEEFRTDPIGLMKRVRSECGDVGWFQLADKQVVLLSGAEANEFFFRS 4858988
4858989 SDSELNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEQMKGHAATIENEVRRMV 4859168
4859169 ESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYHLLERGTDPLCYVDPY 4859348
4859349 LPIESFRIRDEARANLVELVQEVMNGRIANPPKDKSDRDLLDVLVSIKDEDGTPRFSANE 4859528
4859529 VTGMFISLMFAGHHTSSGTASWTLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIP 4859708
4859709 NLDNALKETLRLHPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTF 4859888
4859889 DPDRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEFEMAQPSES 4860068
4860069 YRNDHSKMVVQLARPAKVRYRRR 4860137

CYP51B1 Methylococcus capsulatus (Proteobacteria)

908332 MSHPPSNTP
908305 PVKPGGLPLLGHILEFGKNPHAFLMALRHEFGDVAEFRMFHQRMVLLTGSQASEAFYRAP 908126
908125 DEVLDQGPAYRIMTPIFGRGVVFDARIERKNQQLQMLMPALRDKPMRTYSEIIVAEVEAM 907946
907945 LRDWKDAGTIDLLELTKELTIYTSSHCLLGAEFRHELNTEFAGIYRDLEMGIQPIAYVFP 907766
907765 NLPLPVFKRRDQARVRLQELVTQIMERRARSQERSTNVFQMLIDASYDDGSKLTPH 907598
907597 EITGMLIATIFAGHHTSSGTTAWVLIELLRRPEYLRRVRAEIDALFETHGRVTFESLRQM 907418
907417 PQLENVIKEVLRLHPPLILLMRKVMKDFEVQGMRIEAGKFVCAAPSVTHRIPELFPNPEL 907238
907237 FDPDRYTPERAEDKDLYGWQAFGGGRHKCSGNAFAMFQIKAIVCVLLRNYEFELAAAPE 907061
907060 SYRDDYRKMVVEPASPCLIRYRRRDAP 906980

CYP51B1 Rhodococcus sp. RHA1 (Actinobacteria) Rha05830

MNLATPQRVSGGEHEHGHLEELRTDPIALMRRVREECGNVGVFQLADKKVVLLSGAEANEFFFRSTDEDLDQQAAYPFMKPIFGEGVVFDASPERRKEMLHNQALRGEQMKGHAATIAHEVDRMVAQWGDEGEIDLLEFFAELTIYTSSACLIGKKFREQLDGRFAHLYHELEQGT
DPIAYVDAYAPIESFRRRDEARVQLVALVQEIMNGRIENPPQGKEDRDMLDVLVSIKDEDGNERFTADEITGMFISMMFAGHHTTSGTAAWTLIELLRHPDYAKQVVAELDDLYSDGSDISFGALRQIPKLEAVLKETLRLHPPLIILLRVARGEFEVGGYRIAENDLVAATPAISNRIAE
DFPNPDTFDPERYIDPNQEDIVNRWTWIPFGAGRHRCVGAAFALMQLKAIFSILLQDWEFEMAQPSETYRNDHSKMVVQLQQPCTVRYRKRST

CYP51B1 Nocardia farcinica IFM 10152 (Actinobacteria)

MTLVKPRRVSGGEHEHGHLEEFRTDPIALMRRVRQECGDVGAFE
LAGKQVILLSGAEANEFFFRSGDEDLDQGAAYPFMKPIFGEGVVFDASPERRKEMLHN
SALRAEQMRGHATTIAAEVDRMIAGWDDEGEIDLLDFFAELTIYTSSACLIGVKFRNE
LDDRFARLYHELERGTDALAYVDPYAPIESFRRRDEARAALVALVQAIMDERAANPPA
DKSDRDLLDVLVSVPNEDGGPRFSASEITGIFISMMFAGHHTTSGTAAWTVIELLRHP
ELRDRVVAELDELFADGKDVSFHALRQIPLLEATLKETLRMHPPLIILMRVAQGDFEV
CGHHIAAGDHVAATPAISNRLPEDFPDPDTFDPGRYIDPNQEDLVNRWTWIPFGAGRH
RCVGAAFALMQLKAIFSILLRDWEFEMAQPSESYRNDHSKMVVQLQQPCRVRYRRRVR
TS

CYP51B1 Mycobacterium vanbaalenii

MTAVKEVPRVSGGEEEHGHLEEFRTDPIGLMKRVREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSE
LNQAEAYPFMTPIFGEGVVFDADPERRAEMLHNTALRGEHMKGHATTIEAEVRKMIEGWGESGEIDLLEF
FAELTIYTSTACLIGLKFRNQLDSRFANYYHLLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVM
HGRIANPPKDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSWTLIELLRHPEFY
AKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRLHPPLIILMRVAQDEFEVAGYPIHKGQMVAASP
AISNRIPEDFPNPDDFDPDRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEFEM
AQPPESYQNDHSKMVVQLARPAKVRYRRRVRD

CYP101A1 Pseudomonas putida

MTTETIQSNANLAPLPPHVPEHLVFDFDMYNPSNLSAGVQEAWA
VLQESNVPDLVWTRCNGGHWIATRGQLIREAYEDYRHFSSECPFIPREAGEAYDFIPT
SMDPPEQRQFRALANQVVGMPVVDKLENRIQELACSLIESLRPQGQCNFTEDYAEPFP
IRIFMLLAGLPEEDIPHLKYLTDQMTRPDGSMTFAEAKEALYDYLIPIIEQRRQKPGT
DAISIVANGQVNGRPITSDEAKRMCGLLLVGGLDTVVNFLSFSMEFLAKSPEHRQELI
ERPERIPAACEELLRRFSLVADGRILTSDYEFHGVQLKKGDQILLPQMLSGLDERENA
CPMHVDFSRQKVSHTTFGHGSHLCLGQHLARREIIVTLKEWLTRIPDFSIAPGAQIQH
KSGIVSGVQALPLVWDPATTKAV

CYP101B1 Novosphingobium aromaticivorans

MLPHDRGQNSTRRITAMEAPAHVPADRVVDIDIYMPPGLAEHGF
HKAWSDLSAGNPAVVWTPRNEGHWIALGGEALQEVQSDPERFSSRIIVLPKSVGEMHG
LIPTTIDPPEHRPYRQLLNAHLNPGAIRGLSESIRQTAVDLIEGFAAQGHCNFTAQYA
EQFPIRVFMALVGIEASEAPRIRHWAECMTRPGMDMTFDEAKAVFFDYVGPLVDARRE
TPGEDMISAMINADLGDGRRLTRDEALSVVTQVLIAGLDTVVNVLGFIMRELAGNPAL
RADLRQRGADILPVVHELFRRFGLVSIAREVRRDIEFHGVHLKAGDMIAIPTQVHGLD
PRVNPDPLAIDPSRKRARHSTFGSGPHMCPGQELARKEVAITLEEWLRRIPDFALGPN
SDLSPVPGIVGALRRVELVWNT

CYP101C1 Novosphingobium aromaticivorans

MIPAHVPADRVVDFDIFNPPGVEQDYFAAWKTLLDGPGLVWSTA
NGGHWIAARGDVVRELWGDAERLSSQCLAVTPGLGKVMQFIPLQQDGAEHKAFRTPVM
KGLASRFVVALEPKVQAVARKLMESLRPRGSCDFVSDFAEILPLNIFLTLIDVPLEDR
PRLRQLGVQLTRPDGSMTVEQLKQAADDYLWPFIEKRMAQPGDDLFSRILSEPVGGRP
WTVDEARRMCRNLLFGGLDTVAAMIGMVALHLARHPEDQRLLRERPDLIPAAADELMR
RYPTVAVSRNAVADVDADGVTIRKGDLVYLPSVLHNLDPASFEAPEEVRFDRGLAPIR
HTTMGVGAHRCVGAGLARMEVIVFLREWLGGMPEFALAPDKAVTMKGGNVGACTALPL
VWRA

CYP101D1 Novosphingobium aromaticivorans

MNAQTSTATQKHRVAPPPHVPGHLIREIDAYDLDGLEQGFHEAW
KRVQQPDTPPLVWTPFTGGHWIATRGTLIDEIYRSPERFSSRVIWVPREAGEAYDMVP
TKLDPPEHTPYRKAIDKGLNLAEIRKLEDQIRTIAVEIIEGFADRGHCEFGSEFSTVF
PVRVFLALAGLPVEDATKLGLLANEMTRPSGNTPEEQGRSLEAANKGFFEYVAPIIAA
RRGGSGTDLITRILNVEIDGKPMPDDRALGLVSLLLLGGLDTVVNFLGFMMIYLSRHP
ETVAEMRREPLKLQRGVEELFRRFAVVSDARYVVSDMEFHGTMLKEGDLILLPTALHG
LDDRHHDDPMTVDLSRRDVTHSTFAQGPHRCAGMHLARLEVTVMLQEWLARIPEFRLK
DRAVPIYHSGIVAAVENIPLEWEPQRVSA

CYP101D2 Novosphingobium aromaticivorans

MGTTRMDTFNPQESRLATNFDEAVRAKVERPANVPEDRVYEIDM
YALNGIEDGYHEAWKKVQHPGIPDLIWTPFTGGHWIATNGDTVKEVYSDPTRFSSEVI
FLPKEAGEKYQMVPTKMDPPEHTPYRKALDKGLNLAKIRKVEDKVREVASSLIDSFAA
RGECDFAAEYAELFPVHVFMALADLPLEDIPVLSEYARQMTRPEGNTPEEMATDLEAG
NNGFYAYVDPIIRARVGGDGDDLITLMVNSEINGERIAHDKAQGLISLLLLGGLDTVV
NFLSFFMIHLARHPELVAELRSDPLKLMRGAEEMFRRFPVVSEARMVAKDQEYKGVFL
KRGDMILLPTALHGLDDAANPEPWKLDFSRRSISHSTFGGGPHRCAGMHLARMEVIVT
LEEWLKRIPEFSFKEGETPIYHSGIVAAVENVPLVWPIAR

CYP101D3 Sphingomonas sp. SKA58

1 MPEHVPETMS RARAPRPEHI PEQYVHEIDM YALEGIEQGY HEAWKNIPKP DMPDLIWTPF
61 TGGHWIATNG DTVREVYSDP TRFSSEVIFL PKEAGEKYEM VPTRMDPPEH TPYRKALDKG
121 LSLAQIRKVE SKVRKVAVDL IDSFVSRGEC DFSAEYANVF PVRVFMALAD LPESDVPTLS
181 RFAKMMTRPE GNTPEEMAKH LEEGNKGFFA YVEPIIQARR GKEGEDLITV MVNAEINGER
241 ITHDKALGLI SLLLLGGLDT VVNFLSFMMI HLAKNPQVVE ELRADPLKLM RSAEEMFRRF
301 PVVSEARMVA KDQDFRGIEL KRGDMILLPT ALHGLDDQLN DDPWRINLER RGISHSTFGG
361 GPHRCAGLHL ARMEVIVTIE EWLKRIPTFA MKPGAQPIYH SGIVAAVDNV PLIWSER

CYP102A1 Bacillus megaterium

MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFE
APGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHN
ILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFN
YRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVD
KIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSF
ALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSL
YAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFK
PFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAK
SKKIPLGGIP

CYP102A2 Bacillus subtilis

MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI
HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH
NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF
NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV
DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL
SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF
SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA
YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS
VQSRHQEAIHADVQAAEKAAPDEQKEKTE

CYP102A3 Bacillus subtilis

MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF
DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH
RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF
NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV
DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL
SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF
SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA
YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT
VKPRKTAAINV

CYP102A4 Bacillus anthracis str. Ames

1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFRMQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETQEPNWQ KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YEEYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKNHEIKQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVAAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKG DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQRMWSDAMK VFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF EPFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNVGEAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGQAKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI

CYP102A5 Bacillus cereus ATCC 14579

1 MEKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKIAEEYG PIFQIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG DQEENDLLSR
241 MLNVPDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYMRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFELID YQNYQLDVKQ TLTLKPGDFK IRILPRKQTI SHPTVLAPTE DKLKNDEIKQ
481 HVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSKRGEADAS GDFEEQLEQW KQNMWSDAMK AFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSDRSTRHIE VSLPEGATYK EGDHLGVLPV
721 NSEKNINRIL KRFGLNGKDQ VILSASGRSI NHIPLDSPVS LLALLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELEALL EEGVYHEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAHNRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFELPKDP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MNLGQAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQDEGRYGKD VWAGI

CYP102A6 Bradyrhizobium japonicum USDA 110

1 MSSKNRLDPI PQPPTKPVVG NMLSLDSAAP VQHLTRLAKE LGPIFWLDMM GSPIVVVSGH
61 DLVDELSDEK RFDKTVRGAL RRVRAVGGDG LFTADTREPN WSKAHNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVQKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPFEQI WMQKRRKTLA EDVAFMNKMV DEIIAERRKS AEGIDDKKDM
241 LAAMMTGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYTLYALLKH PDILKKAYDE
301 VDRVFGPDVN AKPTYQQVTQ LTYITQILKE ALRLWPPAPA YGISPLADET IGGGKYKLRK
361 GTFITILVTA LHRDPSVWGP NPDAFDPENF SREAEAKRPI NAWKPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQMHLKETL TMKPEGFKIK VRPRADRERG AYGGPVAAVS
481 SAPRAPRQPT ARPGHNTPML VLYGSNLGTA EELATRMADL AEINGFAVHL GALDEYVGKL
541 PQEGGVLIIC ASYNGAPPDN ATQFVKWLGS DLPKDAFANV RYAVFGCGNS DWAATYQSVP
601 RFIDEQLSGH GARAVYPRGE GDARSDLDGQ FQKWFPAAAQ VATKEFGIDW NFTRTAEDDP
661 LYAIEPVAVT AVNTIVAQGG AVAMKVLVND ELQNKSGSNP SERSTRHIEV QLPSNITYRV
721 GDHLSVVPRN DPTLVDSVAR RFGFLPADQI RLQVAEGRRA QLPVGEAVSV GRLLSEFVEL
781 QQVATRKQIQ IMAEHTRCPV TKPKLLAFVG EEAEPAERYR TEILAMRKSV YDLLLEYPAC
841 ELPFHVYLEM LSLLAPRYYS ISSSPSVDPA RCSITVGVVE GPAASGRGVY KGICSNYLAN
901 RRASDAIYAT VRETKAGFRL PDDSSVPIIM IGPGTGLAPF RGFLQERAAR KAKGASLGPA
961 MLFFGCRHPD QDFLYADELK ALAASGVTEL FTAFSRADGP KTYVQHVLAA QKDKVWPLIE
1021 QGAIIYVCGD GGQMEPDVKA ALVAIRHEKS GSDTATAARW IEEMGATNRY VLDVWAGG

CYP102A7 Bacillus licheniformis ATCC 14580

1 MNKLDGIPIP KTYGPLGNLP LLDKNRVSQS LWKIADEMGP IFQFKFADAI GVFVSSHELV
61 KEVSEESRFD KNMGKGLLKV REFSGDGLFT SWTEEPNWRK AHNILLPSFS QKAMKGYHPM
121 MQDIAVQLIQ KWSRLNQDES IDVPDDMTRL TLDTIGLCGF NYRFNSFYRE GQHPFIESMV
181 RGLSEAMRQT KRFPLQDKLM IQTKRRFNSD VESMFSLVDR IIADRKQAES ESGNDLLSLM
241 LHAKDPETGE KLDDENIRYQ IITFLIAGHE TTSGLLSFAI YLLLKHPDKL KKAYEEADRV
301 LTDPVPSYKQ VQQLKYIRMI LNESIRLWPT APAFSLYAKE ETVIGGKYLI PKGQSVTVLI
361 PKLHRDQSVW GEDAEAFRPE RFEQMDSIPA HAYKPFGNGQ RACIGMQFAL HEATLVLGMI
421 LQYFDLEDHA NYQLKIKESL TLKPDGFTIR VRPRKKEAMT AMPGAQPEEN GRQEERPSAP
481 AAENTHGTPL LVLYGSNLGT AEEIAKELAE EAREQGFHSR TAELDQYAGA IPAEGAVIIV
541 TASYNGNPPD CAKEFVNWLE HDQTDDLRGV KYAVFGCGNR SWASTYQRIP RLIDSVLEKK
601 GAQRLHKLGE GDAGDDFEGQ FESWKYDLWP LLRTEFSLAE PEPNQTETDR QALSVEFVNA
661 PAASPLAKAY QVFTAKISAN RELQCEKSGR STRHIEISLP EGAAYQEGDH LGVLPQNSEV
721 LIGRVFQRFG LNGNEQILIS GRNQASHLPL ERPVHVKDLF QHCVELQEPA TRAQIRELAA
781 HTVCPPHQRE LEDLLKDDVY KDQVLNKRLT MLDLLEQYPA CELPFARFLA LLPPLKPRYY
841 SISSSPQLNP RQTSITVSVV SGPALSGRGH YKGVASNYLA GLEPGDAISC FIREPQSGFR
901 LPEDPETPVI MVGPGTGIAP YRGFLQARRI QRDAGVKLGE AHLYFGCRRP NEDFLYRDEL
961 EQAEKDGIVH LHTAFSRLEG RPKTYVQDLL REDAALLIHL LNEGGRLYVC GDGSRMAPAV
1021 EQALCEAYRI VQGASREESQ SWLSALLEEG RYAKDVWDGG VSQHNVKADC IART

CYP102A8 Bacillus thuringiensis serovar konkukian str. 97-27

1 MDKKVSAIPQ PKTYGPLGNL PLIDKDKPTL SFIKLAEEYG PIFQIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETDEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSFYR ETPHPFITSM
181 TRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSE NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDSTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDDVEEFQ PERFEELDKV PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YEDYQLDVKQ TLTLKPGDFK IRIVPRNQTI SHTTVLAPTE EKLKKHEIKK
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKP DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNM EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYK EGDHLGVLPI
721 NNEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVR LYDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELESLL EDGVYQEQIL KKRISMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGIAPFRGFL QARRVQKQKG MKVGEAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHTAF SRLEGHPKTY VQHVIKEDRI HLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR LQEEGRYGKD VWAGI

CYP102A9 Bacillus weihenstephanensis KBAB4

1 MDKKVSAIPQ PKTYGLLGNL PLIDKDKPTL SFIKIAEEYG PIFRIQTLSD TIIVVSGHEL
61 VAEVCDETRF DKSIEGALAK VRAFAGDGLF TSETHEPNWK KAHNILMPTF SQRAMKDYHA
121 MMVDIAVQLV QKWARLNPNE NVDVPEDMTR LTLDTIGLCG FNYRFNSYYR ETPHPFITSM
181 SRALDEAMHQ LQRLDIEDKL MWRTKRQFQH DIQSMFSLVD NIIAERKSSG NQEENDLLSR
241 MLNVQDPETG EKLDDENIRF QIITFLIAGH ETTSGLLSFA IYFLLKNPDK LKKAYEEVDR
301 VLTDPTPTYQ QVMKLKYIRM ILNESLRLWP TAPAFSLYAK EDTVIGGKYP IKKGEDRISV
361 LIPQLHRDKD AWGDNVEEFQ PERFEELDKI PHHAYKPFGN GQRACIGMQF ALHEATLVMG
421 MLLQHFEFID YQDYQLDVKQ TLTLKPGDFK IRILPRNQTI SHTTVLAPIE EKLKNDEIEQ
481 QVQKTPSIIG ADNLSLLVLY GSDTGVAEGI ARELADTASL EGVQTEVVAL NDRIGSLPKE
541 GAVLIVTSSY NGKPPSNAGQ FVQWLEELKS DELKGVQYAV FGCGDHNWAS TYQRIPRYID
601 EQMAQKGATR FSTRGEADAS GDFEEQLEQW KQSMWSDAMK AFGLELNKNI EKERSTLSLQ
661 FVSRLGGSPL ARTYEAVYAS ILENRELQSS SSERSTRHIE ISLPEGATYQ EGDHLGVLPI
721 NSEKNVNRIL KRFGLNGKDQ VILSASGRSV NHIPLDSPVS LFDLLSYSVE VQEAATRAQI
781 REMVTFTACP PHKKELELLL EEGVYHEQIL KKRMSMLDLL EKYEACEIRF ERFLELLPAL
841 KPRYYSISSS PLVAQDRLSI TVGVVNAPAW SGEGTYEGVA SNYLAQRHNK DEIICFIRTP
901 QSNFQLPENP ETPIIMVGPG TGVAPFRGFL QARRVQKQKG INLGQAHLYF GCRHPEKDYL
961 YRTELENDER DGLISLHIAF SRLEGYPKTY VQHLIKQDRI NLISLLDNGA HLYICGDGSK
1021 MAPDVEDTLC QAYQEIHEVS EQEARNWLDR VQEEGRYGKD VWAGI

CYP102A10 Erythrobacter litoralis HTCC2594

1 MDAPTALAPI PQPPGKPIVG NAFTVDSSRL IQSLMELAEE YGPIFQLEVM GTPLVFVSGA
61 DMVAEICDES RFDKTVRGPL KRLRLIAGDG LFTGDTDDPN WAKAHHILLP SFSQKAMGSY
121 LPMMTDIASQ LMLKWERLNS DDVIDVPMDM VRLTLDTIGV CGFGYRFNSF YREDFHPFIE
181 ALNRTLDTTQ KMRGLPGEKL LKRQQIEQLN EDAAYMNNLV DEIIRERRQT GESGQGDLLD
241 FMLSGRDPVT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLQRAYAEVD
301 EVLGRNIDQT PTLSQIGRLP YIRAILSEAL RLWPTAPAMG LAPFEDEVLG GKYAIAKGTF
361 TTVLIPSLHR DKLVWGENPE AFNPDNFSPK AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLGMLLQR FELFDHADYQ LRIKETLSIK PDGFTIKARL RHDVERGGVA TVEPESKTPD
481 QAAAVPSHGT PLLVLYGSNL GSSEGFAREL AQRGEFSGFD VTMAPLDAHV AKLPTDGAVA
541 IACASYNGMP PDNAAKFVDW LEQADAADAP LSNVSYLVLG CGNSDWAATF QVVPRKIDAL
601 MEQHGAERLV PAEELDARGD LDTQFHDWLD GLIPQLGDAF DIDLESGFDA VFEPLYTVEI
661 TDSITGNTVA DRVGAREVEV VANRELKDTS KDEGRSTRHL EVRLPEGMEY EPGDHLCVVP
721 VNDPAVVDRL LKRFGLDRDT FVRIESRSDM RGPFPSGSTF SVLNLAETAG ELQAVATRKD
781 IATLARYSEC PNSRAALEAL AAPPSADGTD RYTSEVLEKR RSVLDMLEEF PACDVPLAVF
841 LELIPFLSPR YYSISSAPEA NQGLCSITVG VVKGPALAGT GEFKGTCSAY LADLPPGDRF
901 RAVVRKPTAQ FRLPDNPETP VIMIGPGTGV APFRAFLQRR DHLQEDGAVL GEAMLFFGCR
961 HPDIDYLYRE ELDDYDQRGV ATVHAAFSRH DGSRTYVQDL IAREADRVWE LIEQDARIYV
1021 CGDGARMEPD VRKALMAIYA EKKSSDEASA KAWIDDLVAQ DRYLLDVWVG

CYP102A11 Erythrobacter sp. NAP1

1 MATNATLTPI PQPPGKPLIG NALTVDASQQ IQSLMELAEE YGPIFQLDMM GTPIVIISGA
61 DLVAEVCDEK RFDKSVRGPL KRLRLIGGDG LFTGDTDAPN WSKAHNILLP SFSQKAMGSY
121 LPMMTDIATQ LVMKWERMNS DDVIDVPKDM IRLTLDTIGV CGFGYRFNSF YREDFHPFIR
181 ALTRTLETTQ KIRGIPGEKL LKGDAVKQLH RDAKYMNNLV DEIIRERQRS GGDGPEDLLD
241 FMLSGRDPLT GERLSDENIR YQINTFLIAG HETTSGLLSF TLYYLLKNRD VLTRAYAEVD
301 TVLGRNIDQP PSLKQIGQLP YIRAILFEAL RLWPTAPAFG LAPFEDEVLG GKYLIPKGTF
361 TTVLIPSLHR DKSVWGENPE VFDPENFTAE AEAARPPHAY KPFGNGQRAC IGRQFAIQES
421 ILVLAMILQR FELFDHSDYK LDIKETLSIK PDEFTIKARM RKDVERGGKA TEDAEEASTE
481 PAEPKVPKHD TPLLVLYGSN LGSSESFARE VAQKGEFSGF EVEMAPLDDY VGKLPEDGAV
541 AIACASYNGM PPDNAAKFID WIEGKDGAAP DLSGVSYMML GCGNSDWAAT FQAVPRLIDA
601 RMEELGAKRI VPTTELDARS DVDTQFHTWL DALMPQLGEH FDLDLSGEAA GIAEPLYKVE
661 VTQSVTANTV ASRVGAHAVK MVANRELKNT DIGEGRSTRH IEVELAQGET YQPGDHLCVV
721 PENDDAVVER LLRRFNLDAD TYVRIESRSE MRGPFPSGST FSVYNLAKTA GELQAVATRK
781 DIATLALYTE CPNSKPALEK LAQPPQEDGT DQYATDVLAK RKSVLDLLED YPACDLPLAV
841 FLEMIPFLSP RYYSISSAPG DTPQTCSITV GVVKGPALSG KGTFKGTCSN YLAELEPGAS
901 FNAVVREPTA NFRLPDDPKV PLIMVGPGTG LAPFRGFLQE RDALASSGEE LGPARLYFGC
961 RTPDEDFLYR DELEDYDKRG IVTLRTAFSR VDEGKCYVQD HIADDADAIW EMLEAGGRIY
1021 VCGDGARMEP DVRAALAKIH SDKTGSTPAE AQSWVGDLIT NERYSLDVWV G

CYP102A12 Rhodopseudomonas palustris HaA2

1 MSSSNKLAPI PHPPKQPVVG NMLSIDTKAP VQHLVRLAEE LGPIFWLDMM GAPIVIVSGY
61 DLVDEISDEK RFDKAVRGAL RRVRTVGGDG LFTADTSEPN WSKAHNILLT PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRDTLA EDVAFMNAMV DEIIAERRKA AAVADKMDML
241 GAMMTGVDKV TGEPLDDVNI RYQINTFLIA GHETTSGLLS CAIYALLKHP EVLQKAYDEV
301 DRVLGADTSV EPSYQQVNQL GYITQILKET LRLWPPAPAY GVAPIQDETI GGQYHLKRGT
361 FTTVLVLALH RDPSIWGPNP DAFDPENFSR EAESKRPANA WKPFGNGQRA CIGRGFAMHE
421 AALALGMILQ RFKLIDHTRY RMVLKETLTI KPEGFKIKVR PRSDKDRATR IASGVSHSVA
481 PAPAAPRARP GHNTPLLVLY GSNLGTAEEL AHRVADLADL NGFATRLGAL DQYVGQLPEE
541 GGVLIFAASY NGAPPDNATQ FVRWLSGDLP PDAFAKLRYA VFGCGNRDWT ATYQAIPRLI
601 DERLAAHGGR NIFVRGEGDA RDDLEGQFEA WFATLGPLAV KEFGIDAAFD RGADDTPLYG
661 IEPLAPAASQ PLAATGVAVA MRVLENRELQ DRAASGRSTR HIEIALPQGM SYRVGDHLSV
721 IPRNDPALVA AVAQRFGFAP DDQIRLSAAP GRRAQLPVGE AVSIGGLLGD HVELQQVATR
781 KQIVALAAHT RCPQTRPKLQ ALAGGDGAAD DAYRAEVLGK RRSVFDLLQE HPACELPFAA
841 YLEMLTPLQP RYYSISSSPA RDPARASVTV AVVEGPALSG RGIYRGACSS WLAGRGSGDT
901 VQATVRATKA CFRLPDDDRV PLIMIGPGTG VAPFRGFLQE RSARKVGGAT LGPALLFFGC
961 RHPAQDYLYA DELQGFAADG IVELHAAFSR GDGPKTYVQH LIAAQKDRVF ALIEQGAIVY
1021 VCGDGGRMEP DVKAALCAIH RERSGADATA AAAWIADLGA RDRYVLDVWA SV

CYP102A12 Rhodopseudomonas palustris HaA2

1 MPSTNKLDPI PHPPKKPVVG NMLSLDTTAP VQHLVRLAKE LGPIFWLDMM GAPLVIVSGY
61 DLVDEISDEK RFDKAVRGAL RRARAVGGDG LFTADTKEPN WSKAHNILLT PFGGRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MTRGLPLENL WMKKRRETLA DDVVFMNAMV DEIIAERRKA SESAADKKDM
241 LGAMLAGVDR ATGEPLDDVN IRYQINTFLI AGHETTSGLL SCAIYALLKH PDVLQKAYDE
301 VDRVLGSDTA VRPSYQQVNQ LSYITQILKE TLRMWPPAPA YGVAPIKDEV IGGKYHLKRG
361 TFVTVLVLAL HRDPAIWGPN PDAFDPENFS REAESKRPAN AWKPFGNGQR ACIGRGFAMH
421 EAALALGMIL QRFQLIDHQR YRMVLKETLT IKPEGFKIKV RPRSDKDRGD FVAAGASQVS
481 TPALAQAAPR ARPDHNTPLL VLYGSNLGTA EELATRVADL AELNGFSTRL GALDQYVGHL
541 PEEGGVLIFT ASYNGAPPDN ATQFVQWLSG DLPKDAFAKL RYAVFGCGNR DWTATYQAIP
601 RLVDERLAAH GGRNIFLRGE GDARDDLEGQ FESWFAKLGP LAVKEFGIDA KFARAVDDAP
661 LYRIEPVAPA AGNAVAAAGG AVPMKVLANR ELQDCAASGR STRHIEIALP EGISYRVGDH
721 LSVMPRNDPA LVAAVAQRLG FAPDDQIKLQ VAPGRRAQLP IGEAISVGRL LGDFVELQQV
781 ATRKQIAVMA EHTRCPQTRP KLQALAGGDG AADEAYRAGV LAKRKSVYDL MQEHPACELP
841 LHAYLEMLSP LAPRYYSISS SPLRDPSRAA ITVAVVDGPA LSGRGHYRGV CSTWLAGRSV
901 GDTIHATVRA TKAGFRLPDD DRVPLIMIGP GTGLAPFRGF LQERAARQQN GATLGPALLF
961 FGCRHPAQDY LYADELQGFA AEGVVELHTA FSRGEGPKTY VQHLIAAQKD RVFTLIEQGA
1021 IIYVCGDGGK MEPDVRAALM AIHRERSGAD AAAASTWIDD LGACNRYVLD VWASA

CYP102A13 uncultured soil bacterium

1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE LGPIFWLDMM GAPIVIVSGY
61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA TDVAFMNKMV DEIVAERRKS AEASDGKKDM
241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYAIYALLKH PDVLKKAYAE
301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE ALRLWPPAPA YGIAPLKDET IAGGKYSLKK
361 NTFISILVTA LHHDPAVWGP NPDLFDPENF SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL TIKPDGFKIK VRPRSGHDRT VHAEAATAAV
481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA EDLATRVADL AEVNGFATRL APLDDCAGQL
541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG ELPNDAFAKL RYAVFGCGNR DWAATYQSVP
601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ FESWFAALGA AAVKEFGLES RFSRSADDAP
661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR ELQNKSGPDA SERSTRHIEV QLPGGMTYRV
721 GDHLSVVPCN APALVDRVAR RFGFLPADQI RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL
781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG DDADSSERYR ADILSRRKSV YDLLEEFPAI
841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS RCSITVGVVS CPASSTGRGL YRGVCPYYLA
901 SRREGESVFA TVRETKAGFR LPDDPSVPII MIGPGTGLAP FRGFLQERAA RKAGGATLGP
961 AMLFFGCRHP EQDYLYADEL KAFADEGITE LFVAFSRSEG PKTYVQHLLA TQKARVWDLI
1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC TGADANGGAK WIADLGAQNR YVLDVWAGG

CYP102A14 uncultured soil bacterium ABD83817

1 MASNNKMSPI PQPPTRPVVG NMLSLDSAAP VQDLTRLAKE LGPIFWLDMM GAPIVIVSGY
61 TLVDELSVET RLDKVVRGAL RRVRAIGGDG LFTADTAEPN WSKARNILLQ PFGNRAMQSY
121 HPSMVDIAEQ LVKKWERLNA DDEIDVVHDM TALTLDTIGL CGFDYRFNSF YRRDYHPFVE
181 SLVRSLETIM MIRGLPLENF WMRRRRSDLA TDVAFMNKMV DEIVAERRKS AEASDGKKDM
241 LNAMMSGVDR STGEQLDDVN IRYQINTFLI AGHETTSGLL SYAIYALLKH PDVLKKAYAE
301 VDRVLGADIE ARPSYQQVTQ LTYITQILKE ALRLWPPAPA YGIAPLKDET IAGGKYSLKK
361 NTFISILVTA LHHDPAVWGP NPDLFDPENF SPEAEAKRPV NAWRPFGNGQ RACIGRGFAM
421 HEAALALGMI LQRFKLIDHQ RYQIRLKETL TIKPDGFKIK VRPRSGHDRT VHAEAATAAV
481 ATGAALPRAR PRPGHNTPLL VLYGSNLGTA EDLATRVADL AEVNGFATRL APLDDCAGQL
541 PDSGGVLIFC ASYNGAPPDN ATKFVGWLRG ELPNDAFAKL RYAVFGCGNR DWAATYQSVP
601 RLIDETLSAH GGKRVFPRGE GDARSDLDGQ FESWFAALGA AAVKEFGLES RFSRSADDAP
661 LYSVEPVAPS AVNAVAALGG TVPMTILVSR ELQNKSGPDA SERSTRHIEV QLPGGMTYRV
721 GDHLSVVPCN APALVDRVAR RFGFLPADQI RLAVAEGRRA QLPVGEAVSI GQLLTDFVEL
781 QQVATRKQIQ IMSEHTRCPV TKPKLVAYVG DDADSSERYR ADILSRRKSV YDLLEEFPAI
841 ELPFPAYLEM LSLLAPRYYS ISSSPTGDAS RCSITVGVVS CPASSTGRGL YRGVCPYYLA
901 SRREGESVFA TVRETKAGFR LPDDPSVPII MIGPGTGLAP FRGFLQERAA RKAGGATLGP
961 AMLFFGCRHP EQDYLYADEL KAFADEGITE LFVAFSRSEG PKTYVQHLLA TQKARVWDLI
1021 EQGAVIFVCG DGSKMEPDVK ATLVQIYRDC TGADANGGAK WIADLGAQNR YVLDVWAGG

CYP102A15 Bacillus pumilus ATCC 7061 ZP_03053227

1 MQQTSIIPKP KTYGPFKNIP HIKKGELSQT FWRLADELGP IFQFEFSKAT SIFVSNHELF
61 QEICDESRFD KYIGTSLNKV RAFAGDGLFT SWTEEPNWRK AHHILMPAFS QQAMKGYHEM
121 MLDIATQLVQ KWQRTGRDEE IEVAEDMTKL TLDTIGLCGF DFRFNSFYKE NQHPFIESMV
181 NGLSEAMDQA SRLPVADKLM IKRRKKFEEN VDFMKQLVDD IIQERKKQDK TGDDLLSLML
241 HAKDPETGER LSDENIRYQI ITFLIAGHET TSGLLSFAIY FLLKNPEKLK KAVQEADDVL
301 QGGLPTFKQV QKLNYTRMVL NESLRLWPTA PTFSLYAKED TVIGGKYSIE KNQSVSVLLP
361 KLHRDQAVWG EDAEEFKPER FLHPEKIPQH AYKPFGNGQR ACIGMQFALH EATMVLAMVL
421 HNLELIDHTS YELDLKESLT IKPNDFKIKV RPRKQQLFMV PPKEETKKST TTDESKVKSH
481 GTPLLVLYGS NLGTAQQIAN ELAEEGKAKG FDVTTAPLDD YTRQLPDKGA VFIVTASYNG
541 HPPDHAKKFV DWVTQEKEQD LTNVTFAVFG CGDRNWASTY QRIPRLIDEA LERKGAKRAA
601 DLGEGDAGGD MDEDKEAFQK TVFKQLAKEF QLTFQEKGKE NPKLSVAYTN ELVERPVAKT
661 YGAFSAVVLK NEELQSEKSE RQTRHIELQL PEGKKYKEGD HIGIVPKNSD ALVQRVINRF
721 NLDPKQHIKL YSEKKANHLP LDQPIQMREL LASHVELQEP ATRTQLRELA AYTVCPPHRV
781 ELEQMAGEAY QEAILKKRVT MLDLLDQYEA CELSFVHFLA LLPGLKPRYY SISSSPKVDE
841 KRVSITVAVV KGKAWSGRGE YAGVASNYLC GLKEGEEVAC FLHEAQAGFQ LPPSSEVPMI
901 MIGPGTGIAP FRGFVQAREV WQKEGKPLGE AHLYFGCRHP HEDDLYFEEM QLAAQKGVVH
961 IHRAYSRHKE QKVYVQHLLK EDGGMLIKLL DQGAYLYVCG DGKVMAPDVE ATLIDLYQHE
1021 KQCSKEAAEN WLTTLANNNR YVKDVWS

CYP102B1 Streptomyces coelicolor cosmid F43.

MAQTAREPARDGLPKGFRSAELGWPELHRIPHPPYRLPLLGDVV
GASRRTPMQDSLRYARRLGPIFRRRAFGKEFVFVWGAALAADLADEARFAKHVGLGVA
NLRPVAGDGLFTAYNHEPNWQLAHDVLAPGFSREAMAGYHVMMLDVAARLTGHWDLAE
ASGRAVDVPGDMTKLTLETIARTGFGHDFGSFERSRLHPFVTAMVGTLGYAQRLNTVP
APLAPWLLRDASRRNAADIAHLNRTVDDLVRERRANGGTGGGTGSGSGSGDLLDRMLE
TAHPRTGERLSPQNVRRQVITFLVAGHETTSGALSFALHYLAQHPDVAARARAEVDRV
WGDTEAPGYEQVAKLRYVRRVLDESLRLWPTAPGFAREAREDTVLGGTHPMRRGAWAL
VLTGMLHRDPEVWGADAERFDPDRFDAKAVRSRAPHTFKPFGTGARACIGRQFALHEA
TLVLGLLLRRYELRPEPGYRLRVTERLTLMPEGLRLHLVRRTAAAPAPGRRTAAPGAA
DDAGDTVSAPGCPVHRAGD

CYP102B2 Streptomyces avermitilis

MAQSTRTVIPKGFRSAELGWPELHRIPHPPHRLPVVGDVLGVNV
RTPVQDSLRIGRRLGPVFRRKAFGKEIVFVGGADLAAELADESRFAKHVGLGVANLRP
VAGDGLFTAYNHEPNWQLGHDVLAPGFSREAMAGYHPMMLAVTERLIDHWDREQTAGR
AVDVPGDMTKLTLETIARTGFGHDFGSFERARPHPFVTAMVGTLTYAQRRNVVPEPLA
PLLLRTATRRNAADLAYLNRTVDALVRARRTTSGEGDLLDRMLDTARPGTGERLAPEN
IRRQVITFLVAGHETTSGALSFALHYLSRHPDVAARARAEVDRVWGGTARPGYDQVAK
LRYVRRVLDESLRLWPTAPAFAREARRDTVLGGVHPMREGAWALVLTAMLHRDPGVWG
ADAERFDPDRFDAQAVRSRAAHTFKPFGTGARACIGRQFALHEATLVLGLLLRRYELR
AEPGYRLRVAERLTLMPEGLRLRLDRRVPAVEDVPVANPEVSSGPRCPVTGAGE

CYP102B3 Rhodococcus sp. RHA1 Rha05872

MPVTVLLDTGSVRGTLRTRHQFSNAGHIDTGVDMSVESLHTTADATIPHPRWRLPVVGDVFGISIRTPLQNSMEIGRKLGPIFERNVLGNRFVFASGADMVAELSDESRFAKHLAPGVASLREVGGDGLFTAYNHEPNWSKAHNLLAPAFTKSAMRSYHRTMLDVAGELTEHWDER
VDGSPVDVSSDMTKLTLETIGRTGFSYSFDSFGRERPHPFVQAMVGALSHSQRTTFVKSSALGRLLMRRSDRRNIANLEHMAEVVDEVIRARRDSAEDGPEDLLELMLRAARENDPHRIDELNIRHQVVTFLVAGHETTSGALSFALYYLSRHPDVLAKAQAEVDAVWGDEEPAFEQI
AKLRYVRRVLDESLRLWPTAPAYGREATVDTTLVGKYPMKVGDWVLVLIPALHRDPVWGDDPEAFDPDHFLPERIRSRPAHVYKPFGTGERACIGRQFALHESVLVLGTILRRYDIVGDPDYRLKVAERLTLMPEGFTLQLRRR

CYP102B4 Streptomyces scabies SCAB9321

MTATTAATAI SGFRSAELGW PELHRIPHPP FRIPLLGDVL GTNVRTPVQE STRLGQRLGP
IFRRKAFGKE IVFVGGAELA AEMADEARFA KHVGVGVANL RPVAGDGLFT AYNHEPNWQL
AHDVLAPGFG REAMAGYHPM MLDVAERLIE HWDREETAGS AVDVPGDMTK LTLETIARTG
FGHDFGSFER TRPHPFVAAM VGTLTYAQQR NVVPDPLVPV LLRGAAQQNR ADMAFLVETV
DAVVRARRSP GGGRGAGDGD LLDRMLETAH PETGERLSAE NVRRQVITFL VAGHETTSGA
LSFALHYLAR YPDLAARARA EVDRVWGDAA RPGYEQVAKL RYVRRVLDEA LRLWPTAPAF
SREAREDTVL GGVHPMRRGA WALVLTSMLH RDPEVWGADA ERFDPDRFDA AAVRGRAPHT
FKPFGTGARA CIGRQFALHE ATLVLGLLLR RYELTPEPGY RLRVVERLTL MPDGLRLRVR
RRAGAGTDAP RTPSSPPTPS SAPSGRPVTG AGE

CYP102C1 Rhodococcus sp. X309

AAAGGKIDATADANKLALDVIGLAGFGYDFASFDGDEHPFVGAM
SRVLEHVNRTSNDIPFLRKLRGNGADLQYEKDIAFVRTVVDDVITERQAKPGEHQDDL
LDLMLNNIDDETGEKLDPVNIRNQVLTFLVAGNETTAGAIAFALYFLSRHPEIADAAR
AEVADITGGETPAFEDVARMRYLRRVVDETLRLWPSAPGYFRKVRTDTTLGGRYAMPK
GSWVFVLLPQLHRDPVWGENPDSFDPDRFKPENVKKRPAHAYRPFGTGPRSCIGRQFA
LHEAVLSLATILQRYSFQSDPEYKLDVREALTLKPVGLELSLQRL

CYP102C2 Rhodococcus erythropolis PR4

1 MNGPRGSRTR PRRASLVNLA VLGVVLVHTV LMSADKCPYP KSATRAGEIT AVQPQVFESI
61 PSPAWRLPLL GDLLTVDSEK PIQKEMALAS KLGPIFEWKI VNNRVTVVSG VDLVAEVNNE
121 ALWAKSVGLP ILKLRKVAED GLFTAFNSEP NWRKAHNILS EGFSRSALRN YHPSMLRALG
181 GLTDSWDRVA DAGETIDASS DANKLALDVI GLAGFGYDFA SFIGEEHPFV GAMSRVLAHV
241 NSTSNDIPFL RKLRGNGADL QNEKDIALLR TVVDNVIAER QSKPGEHQDD LLDLMLHSAD
301 AETGEKLDPV NIRNQVFTFL VAGNETTAGT LAFALYFLSR HPDVADTARA EVADVTAGET
361 PAFEDVARMR YLRRVVDETL RLWPSAPGYF RKVRTDTTLG GRYDMPKGSW VFVLLPQLHR
421 DPVWGEDPES FDPDRFKPEN VKKRPAHAYR PFGTGPRACI GRQFALHEAV LALAIILQRY
481 NFQSDPEYKL DIRETLSLKP VGFELSLQRR

CYP102D1 Streptomyces avermitilis

MTTQPETDLRPIRSPRGVPLFGHTPQIPSTNPVEYFGKLSKQFP
EGLYGMEIAGIEQVFVWDPDLVAEVCDETRFFKQIDKTPLAHVRDYAGAGLFTAHQHE
EEWGMAHRVLLPVFSQRAMKGYFGQMLEIAQNLVGKWERKEGQPVNITDDYTRLTLDT
IALSGFGYRFDSFAKEDLHPFLNALLQALVESLRRSQELPVMTKMRKADDKKYRENIR
LMRDLVENVIKERREGKGTGEDDLLGLMLEATDPETGKGLDDDNVRDQVVTFLIAGHE
TTSGLLSFATYSLMRNPHILAQAYAEVDRLLPGDTVPDYDTIMQMDVIPRILEETLRL
WAPIPMIGKSPLEDTVIGGCYGLKKGARVNILEGPLHTHPKAWERPEEFDINRWLPEN
RVNHHPHAYKPFGNGVRACIGRQFALTEARLALALVLQKFKFADTDDYKMDVKEALTR
KPGGFELNVRARQEHERTVFGAAD

CYP102E1 Ralstonia metallidurans

MSTATPAAALEPIPRDPGWPIFGNLFQITPGEVGQHLLARSRHHDGIFELDFAGKRVPFVS
SVALASELCDATRFRKIIGPPLSYLRDMAGDGLFTAHSDEPNWGCAHRILMPAFSQRAM
KAYFDVMLRVANRLVDKWDRQGPDADIAVADDMTRLTLDTIALAGFGYDFASFASDELDP
FVMAMVGALGEAMQKLTRLPIQDRFMGRAHRQAAEDIAYMRNLVDDVIRQRRVSPTSGMD
LLNLMLEARDPETDRRLDDANIRNQVITFLIAGHETTSGLLTFALYELLRNPGVLAQAY
AEVDTVLPGDALPVYADLARMPVLDRVLKETLRLWPTAPAFAVAPFDDVVLGGRYRLRKD
RRISVVLTALHRDPKVWANPERFDIDRFLPENEAKLPAHAYMPFGQGERACIGRQFALTE
AKLALALMLRNFAFQDPHDYQFRLKETLTIKPDQFVLRVRRRRPHERFV
TRQASQAVADAAQTDVRGHGQAMTVLCASSLGTARELAEQIHAGAIAAGFDAKLADLDDA
VGVLPTSGLVVVVAATYNGRAPDSARKFEAMLDADDASGYRANGMRLALLGCGNSQWATY
QAFPRRVFDFFITAGAVPLLPRGEADGNGDFDQAAERWLAQLWQALQADGAGTGGLGVDV
QVRSMAAIRAETLPAGTQAFTVLSNDELVGDPSGLWDFSIEAPRTSTRDIRLQLPPGITY
RTGDHIAVWPQNDAQLVSELCERLDLDPDAQATISAPHGMGRGLPIDQALPVRQLLTHFI
ELQDVVSRQTLRALAQATRCPFTKQSIEQLASDDAEHGYA

CYP102F1 Actinosynnema pretiosum subsp. auranticum

MVATGTRIPGPKPLPLVGNLLDVLTSDLDTDVDFLDRCHREHGG
IVALTFAGQRQVFASSHELVARMCSDPSWGKAVHPALEQVRDFAGDGLFTARGDEPNW
GKAHRLLMPAFGPTAMRDHFPAMLDIAEQMLVRWRRFGPDHRIDVADDMTRLTLDTIA
LCAFGARFNSFYRDRAHPFVDAMVRSLVEAGERAERLPGVQPFLVGRNQRYRDDIATM
NRIADGIVAARAALPAGERPDDLLERMLTCADPVTGERLSARNVRYQLATFLIAGHET
TSGLLSFAVHRLLAHPEVLRKAKDAVDGVLGDRVPAFEDLARLDYLGQVLRETLRLHP
TAPAFALAPDEPAELGGHAIGAGEPVLVMLPTLHRDPAVWRDPDVFDPERFAPERMDE
IPACAWMPFGHGARACIGRPFALQEATLVLALVLQRFDLALADPDHRLTIKQTLTLKP
DSLVVRARPRADRPGATATVETVVPHQVPATHRHGTPLHVFYGSNGGSGEGLARTIAG
DGAARGWATSVAPLDDAVRALPASGPVVIVSSSYNGAPPDNAAHFVRWLTQDGPDLSG
VDYLVLGCGNLDWSATYQRVPTLIDEAMAAAGARRLRERGATDARADFFGDWERWYEP
LWPLLSAECGVEVGEIGPRFRVVESDAADGLGDLASAVVLENRELVRGPDAGSKRHLE
LRLPDGTSYRTGDYLSVLPQNHPDLVRRAVARLGTRAERVVTVESSAPTGLVPVGRAL
RVDELLTRCVDLSAPAGAGVVARLAERCPCPPERAELAATTGATLLELLERFPSCAVD
LALALELLPAPRTRLYSISSAAEEQRAEVALTVSVTGVTSGYLSRVRPGDRVAVGIAS
PPESFRPPADNTVPVVLIAAGTGIAPFRGFLRARAALGGEPGPALLLFGCRGPELDDL
YAEEFAALGDWLEVDRAYSRHPDGEVRHVQHRLWQRRDRVRELVDAGARVYLCGDATR
VGPAVEEVLGRIGPGAGWLDALRAGGRYATDVF

CYP102G1 Streptomyces scabies SCAB5931

MTHATERGTE SIPERSALPL VGHAFDIPGG ADGLLHLMKE ARELGPLFKL RVFGNEINIA
SGLDLVTELS DESRFRKNVH ADLVLVREIT GDGLFTAFND EPNWRKAHDV LMPAFSLGAM
RGYHATMLKV ARELIGKWDG AAGTEPVDVA EDMTRLTFDT IGLCGFGHDF ESFGRPEPHP
FVTALSRALG FAQAKGESIP GLDLFKWKQA EQFRTDVAVM RDLVDDVIRE RRASGDTGTD
DLLGRMLHTR DQVTGEPLDD VNIRHQAITF LIAGHETTSG ALSFALYYLT KHPEVLARAQ
AEVDALWGDT DTPDPDYGDI GKLTYIRQVL NEGLRLWPTA PAYAVEPLED TVIGGRYAVR
EGETIQVLIP QLHRDPAWGE NVELFDPDRF LPEREQERPV HLFKPFGSGE RACIGRQFAL
HEATLVLALV IHRYRLIDHT DYQLKIKQSL TIKPDEFTLR LARRTAGERR LPLVASDRAP
AGEAPPAVRR AAGTTLTLLH GSNLGTCAGI ARELAEDGEQ HGFAPTVASL DSAAGTLSAV
DGPVVIVAAS YNGRPTDDAT RFMEWLDDLA PGSLDGLRYA VLGVGDRNWA ATYQRVPALI
DERLSAAGAT ALLERGAADA SGDFAGTVDR WTGELWTTLL DRHGTAQDGV AAQPDTDAEG
GLYVLEDTTD SVIGGLAARH GVQPMEVLDA RELVDMSHGL GRSKRFLRLR LPEGVTYRTG
DHLAVLPRNP DHLVRRVTDR FGLDPDRTVR LRARRRGRNT LPVDRPLTVR RLLTDFVELQ
DPATREQIAV LAEHTACPPE KRPLTELAAA DPETFREQVT AAGRSVLDLL ERHRACELPF
ERFLELLPVL RPRPYSISSS ALAAPGEVDL MVSLLAAPHR AGEGMFHGIG SHFLQTVRPG
DTLQARVLPC SEAFRLPDDT SASVILVSAG TGLAPFRGAV LDRRHAGSTG TLLCYFGCDH
PDVDYLHRAE FEAAEAAGAV SMRPAFSCAP EDGVRFVQDR IGKESDEVWA ALEAGARVHV
CGDGRRMAPA VREAFRALYR ENTGADDAEA TAWLDALTES GHYVEDVWAG

CYP102G2 Saccharopolyspora erythraea NRRL23338

MTQTPLHHDDVPVADVSGTGLTATPTQQAMELARRHGPVFRRRTREFQSLLVSDVDLVAE
LSDEQRFAKAVGPALENVREFAADGLFTAYNDEFNWAKAHDILMPAFALGSMRTYHPVML
RVARRLLDSWDRAAAASAPVDVPDDMTRMTLDTIGLAGFGFDFGSFGRAEPHPFVGAMVR
CLDWSMTRLSRVPGTDHSERDEAFRADARYLASVVDEVINTRAAEGDTSGEDLLGLMLGA
RHPADGTTLDAANIRNQIITFLIAGHETTSGTLSFALHYLAKNPTVLRLVQREADELWGD
SPDPEPSFEDIGRLTYTRQVLNETLRLWPSAPAFGRQARHDTVLGGRIPMRAGEAAAVLI
PMLHRSPVRGDNPELFDPARFAPEAEAARGPHAFKPFGTGERACIGRQFALDEATMVLAM
LAHRYRLVDHAGYRLKVKETLTLKPEGLTLAVRARTAADRVTNRLALPVGLPSAAPGEPA
DAARRPGRVLPGTGLLLLHGSNYGTCRDFAAQLALAAGELGCDTAVAPLDEYAGNLPSDR
PVIVVAASYNGRPTDDAVSFSRWLDEAEPGAADGVDFAVLGVGDRNWAATYQHVPTRIDA
RLAELGGTRILERGEADASGDLAGAVRRFSAALETALLERSGDPDAVAAAPEGDGPAYTV
SEVTGGALDSLAARHGMVEMTVTEVADLTAPDYPRTKRFVRLALPEGTAYRTADHLAVLP
VHDAALVERAAGVLGVDLDTVLDIRAKRPGRLTFDRSLTVRELLSHHVELQDPPTPDGLD
ALAALNPCPPERAALRGLAEEARSGTADHRTLWDLIEDHPALRDALSWSALLELLPATRP
RQYSVSSSPAVDPRHVDLMVSVLRAPARSGRGEFRGAGSRHLSEVRPGDTVLARVQPCRE
DFRVAPDEPLIMVAAGTGLAPFRGVIADRRERVANGARQAPALCYFGCDAPDADYLHSAE
LRAAESAGAVAMRPAFNEAPVGGQCFVQHRIAAEAGEVWALLESGARVLVCGDGRHMAPG
VREAFRGIYRERTPGADDASAHEWLQAMIAGGCYVEDVYAG

CYP102H1 Nocardia farcinica IFM 10152 plasmid pNF1

MAVTTSTTSGGHSNPPLPHPKWRLPIINDLLTINPIKPTLTSLR
DAEQLGGIFERRLVDWPMIVVSDSELITEICDERNWAKHLGVPLRKMRHIARDGLFTA
RNDEPNWAKAHAVLAPAFTKEAMRSYHQTMLTTIGELLDYWAKRDGQWVDVGEDMNKL
TLEIIARTGFDYTFDSFTRSEVHPFVAAMLRGLTYISRNSNMPPFLQKTIGARAAARH
SRDITYVRTVVDDVIKARQASGTVGDHHDLLDRMLTVPDPASDELLDTTNVRSQILTM
LVAGHETSAGVLAFALYELSRRPELVAAARAEIETRFADGDLSTIAYDDVAKLRTLRR
IVDETLRLYPVAPGFFREARHETTIGGGRYRFGPGDWVLVLTLHAHRDPATWGPDAGE
FQPDRWLPERMRSLDGRQVFKPFGTGLRACIGRQFAYHEIVLALAHILHTFEFTPDPG
YELDIAEQITLKPHRFRLRLNHR

CYP102J1 Burkholderia sp. 383 ABB05850 50% to CYP102A4

1 MKSSSLVPQP PLKPVIGHLM EVLGPSPLAK MMDLARTYGP VYWFEVFGQG YYVVSGQTLV
61 DEVCDETRFQ KCVHQSLLEL RPAIGDGLFT AFGDEPNWAK AHRVLMQAFG PLSIWSMFDK
121 MVDIADQMFL HWERFGPETP VDVSDHMTRL TLDTIALCAF DCRFNSFYRE DQHPFVDAMV
181 NTLSEAGKRE LRPKLVSKLM VKRSRQFDAD IEVMRSLATK MIEDRRKNPH VNEESMDLLD
241 RMLNGIDPVT GEKLDDENIV FQMITFLIAG HETTSGLLSF ATYFLLKNPD ILQKARDMVD
301 EVVGSETPRI EHLARLRYVE QILMETLRIW PTAPGFAVKP LADTTFGGKY AVSPDDIIMI
361 LTPMLHRDVS VWGEDVEAFR PERFAPENAE QLPPNSWKPF GNGARACIGR PFAMQEAHLV
421 LIMLLQRFDF SFADPDYELD VAETLTLKPA GFRVNVKPRA RGALKVPDTA LHARSNAQSP
481 SVAPVQSIAP GEDLSNLLVL FGGNTGSAES FARRIAGDAS RHGFHATCAP LDDFAGKLGG
541 YPAIVIVTAS YEGQPPDNAK SFVPYVEALD EGALDGVHFS VLGCGNKQWA RTYQAIPKRV
601 DEALEKAGAT RVHFRGELDS GGDFFGEFDR WYTEMWNRFA ISAGKEIPVI QHDDVALKVS
661 FAGSSREKVL NLGDMAHASI VDNRELVDIS VAGSRSKKHI ELKLPEAMTY RSGDYLAVLP
721 RNAKNNVDRV LRRFRVSWDT QVVIEGTSSN PRLPLGQAIG CGELFSSYVE LAVPATRSQV
781 SSLAAATRCP PEKVELERLS ADGFECEILG KRTTVMDLLE RFGSVDLSLE KFLDMLPALK
841 ARQYSISSSP LWKADHVTLT VAVVDAPALS GNGRHEGVAS SYLARLNTGD SLSVAVRPSN
901 ARFRPPAEPD LPMILICAGS GIAPFRGFLQ ERALQKQRGE NVGTSLLFFG IDDPDVDFLY
961 RDELDEWARC GVVEVMPAYS NRPEEGARFV QDKVWLERER ISALFSQGAT VFVCGDGKNM
1021 APAVRATLGR IYQETTGEND ESASAWIDTM EREHGRYVAD VFA

CYP103A1 Agrobacterium tumefaciens

MIANSSTDVSVADQKFLNVAKSNQIDPDAVPISRLDSEGHSIFA
EWRPKRPFLRREDGIFLVLRADHIFLLGTDPRTRQIETELMLNRGVKAGAVFDFIDHS
MLFSNGETHGKRRSGLSKAFSFRMVEALRPEIAKITECLWDDLQKVDDFNFTEMYASQ
LPALTIASVLGLPSEDTPFFTRLVYKVSRCLSPSWRDEEFEEIEASAIELQDYVRSVI
ADSGRRMRDDFLSRYLKAVREAGTLSPIEEIMQLMLIILAGSDTTRTAMVMVTALALQ
NPALWSSLRGNQSYVAAAVEEGLRFEPPVGSFPRLALKDIDLDGYVLPKGSLLALSVM
SGLRDEKHYEHPQLFDVGRQQMRWHLGFGAGVHRCLGETLARIELQEGLRTLLRRAPN
LAVVGDWPRMMGHGGIRRATDMMVKLSFDL

CYP103A2 Agrobacterium tumefaciens

MITSSISGTDQQFQNATQPKELDPDAVPVSRLDSEGHEIFAEWR
PKRPFLRREDGVFLVLRADDIFLLGTDPRTRQIETELMLNRGVTRGAVFDLIRYSMLF
SNGEVHVKRRSAFAKTFAFRMIDALRPEITKLTEHLWDDVPRVDDFDFAEMYASKLPA
LTIASVLGLPFGDAPFFTRLVYNVSRCLSPSWGEDDFPEIEASAVELQDYVRAVVADR
SRRISDDFLSCYLKAVREEGTLSPIEEIMQLVFLILAGSDATRNAMVMLPTLLLQNPV
VWSSLCHDQSGVAAAVEEGLRFEPSVGSFPRLALEDIDLDGYVLPKGSFLALSIMSGL
RDERHYEHPQLFDIKRKQMRRHLGFGAGVHRCLGEALARIELQEGLRTLLRRAPSLRV
TGDWPRMIGHGGARRATGMTVNLGVDR”

CYP103A3 Agrobacterium tumefaciens plasmid pTiAB2/73 vir

MNARGPEKVSQTSGPIISASLDPDNVSVSDLDRSGHAIFAEWRP
KRPFLRRQDGVYVLLRADDVLGLSSDPRTRQIETELMLNRGINEGAVFDFVRYSMLFS
NNEVHSRRRSPFTRTFAFRMIENLRPQVSQLTETLFQDLKELDSFNFVEEFASKLPAV
AIAGLLGLPPSDIPYFTQLVYRVARCLSPSWRDADLPDIEASAAEFKNYVQAVIDDRR
SNPRDDFLSSFIRATREAEDLSPDEGLAQLMLIVLAGTDTTKTGLTALTGQLLRHRHV
WEALLKDESLVPAAVEEGLRFEPPVGSYPRLALADIDLEGFILPKGSLLALCTMSALR
DEKHFAHPELFDIHRKQMHWHMVFGAGAHRCLGEALARLELQEGLATVLRYAPTLSIE
GEWPTVQGHGGVRRIAEMRVGFRRQI

CYP104A1 Agrobacterium tumefaciens

MEERRVSISSITWRFPMLFAPVDDVTTIDDLTLDPYPIYRRMRV
QNPVVHVASVRRTFLTKAFDTKMVKDDPSRFSSDDPSTPMKPAFQAHTLMRKDGTEHA
RERMAMARAFAPKAIADHWAPIYRDIVNEYLDRLPRGDTVDLFAEICGPVAARILAHI
LGICEASDVEIIRWSQRLIDGAGNFGWRSELFERSDEANAEMNCLFNDLVKKHRSAPN
PSAFATMLNAPDPIPLSQIYANIKIAIGGGVNEPRDALGTILYGLLTNPEQLEEVKRQ
QCWGQAFEEGLRWVAPIQASSRLVREDTEIRGFIVPKGDIVMTIQASANRDEDVFEDG
ESFNVFRPKSAHQSFGSGPHHCPGAQISRQTVGAIMLPILFDRFPDMILPHPELVQWR
GFGFRGPINLPVTLR

CYP104A2 Agrobacterium tumefaciens

MQLAPVDRVTTIDDLTLDPYPIYRRMRAQTPVVRVASVMRTFLT
KASDTKMVKDQPRRFSSDDPNTPMKPAFQAHTLMRKDGAEHARERMAMAKAFAPKTTA
EHWAAIYRDIVNEYLDRLSRGSTVDLFAEICGPVAARILAHVLGISEASDAEMIRWSQ
RLIEGAGNFGWRPEPFERANEANAEMNRLFDNLVEKHRAEPNPSAFAIMVTASDPIPM
SQIYANIKIAVGGGINEPRDALGTIIYGLLTNPEQFEEVKRQQCWGQVFEEGVRWVAP
IQASSRLVLEDTEIRGFLVPKGDTVMTIQASANRDEDVFDDGERFNVFRQNNAHQSFG
SGPHHCAGAQISRQTVGAIMLPTLFERFPNMTLTNPDAVQWRGFGFRGPISLPVTLI

CYP105A1 Streptomyces griseolus

MTDTATTPQTTDAPAFPSNRSCPYQLPDGYAQLRDTPGPLHRVT
LYDGRQAWVVTKHEAARKLLGDPRLSSNRTDDNFPATSPRFEAVRESPQAFIGLDPPE
HGTRRRMTISEFTVKRIKGMRPEVEEVVHGFLDEMLAAGPTADLVSQFALPVPSMVIC
RLLGVPYADHEFFQDASKRLVQSTDAQSALTARNDLAGYLDGLITQFQTEPGAGLVGA
LVADQLANGEIDREELISTAMLLLIAGHETTASMTSLSVITLLDHPEQYAALRADRSL
VPGAVEELLRYLAIADIAGGRVATADIEVEGHLIRAGEGVIVVNSIANRDGTVYEDPD
ALDIHRSARHHLAFGFGVHQCLGQNLARLELEVILNALMDRVPTLRLAVPVEQLVLRP
GTTIQGVNELPVTW

CYP105A2 Amycolata autotrophica

MTTDATDPRTTDAAPFPSNRSAPYRFSDGYAQLRDPPGPLRLGT
RYDGRQAWVVVIHEAARKLLASRFESADAHRTGFPFLTAGGRDMIGTNPTLFRMDDPE
HARLRRMTISHYTVKRIKTISEFVEEVVLVFLRRMTISGPTADLVSQFLIGAGHMVIC
RLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLQYLARLARTKRERPDDAIIS
RLVARGEILREEDISDAMLLLIAGHATDANLTSMSLYALADRSEQYAALRADRSLVPG
AVEDPLRYVAIADIATEDVPIRGRTIAAGNTQIAMGSSANLDHEYYEDPDALTARVED
LVHLAFGFGRHQCLGQNLARADQLREDLMTARNDPTLRLAVPVQSSARLEGTTIQGVN
ELPVTW

CYP105A3 Streptomyces carbophilus

MTEMTEKATTFLTSQEAPAFPADRTCPYQLPTAYSRLRDEPDAL
RPVTLYDGRRAWVVTKHEAARRLLADPRLSSDRLHADFPATSPRFKAFRQGSPAFIGM
DPPEHGTRRRMTISEFTVKRIKGMRPDVERIVHGFIDDMLAAGPTADLVSQFALPVPS
MVICHMLGVPYADHEFFQDASKRLVQAVDADSAVAARDDFERYLDGLITKLESEPGTG
LLGKLVTHQLADGEIDRAELISTALLLLVAGHETTASMTSLSVITLLEHPDQHAALRA
DPSLVPGAVEELLRVLAIADIAGGRIATADIEIDGQLIRAGEGVIVTNSIANRDSSVF
ENPDRLDVHRSARHHLSFGYGVHQCLGQNLARLELEVILTVLFDRIPTLRLAVPVEQL
TLRPGTTIQGVNELPVTW

CYP105B1 Streptomyces griseolus

MTTAERTAPPDALTVPASRAPGCPFDPAPDVTEAARTEPVTRAT
LWDGSSCWLVTRHQDVRAVLGDPRFSADAHRTGFPFLTAGGREIIGTNPTFLRMDDPE
HARLRRMLTADFIVKKVEAMRPEVQRLADDLVDRMTTGRTSADLVTEFALPLPSLVIC
LLLGVPYEDHAFFQERSRVLLTLRSTPEEVRAAQDELLEYLARLARTKRERPDDAIIS
RLVARGELDDTQIATMGRLLLVAGHETTANMTALSTLVLLRNPDQLARLRAEPALVKG
AVEELLRYLTIVHNGVPRIATEDVLIGGRTIAAGEGVLCMISSANRDAEVFPGGDDLD
VARDARRHVAFGFGVHQCLGQPLARVELQIAIETLLRRLPDLRLAVPHEEIPFRGDMA
IYGVHSLPIAW

CYP105B2 Streptomyces tubercidicus strain R-922

MTTAERTEAERNTGSTGPSEDLAPLSPLAVPAARADGCPFDPAPGVERARREEPVTRATLWDGSTCWLVTRHQDVR
EVLGDPRFSADAARPGFPFLTAGGRVLATSKPTFIRQDDPEHARLRRMLTADFMVKKMEAMRPEVQRLADDLLDRM
TAGRNAADLVAEFALPLPSLVICLLLGVPYDDHEFFQDRSRLLLSLRSTAEEVRTAQADLQRYLSRLAAAKQREPD
DGIVSRLVARGELDFEEIASMGRLLLIAGHETTANMTALSTLALLRNPGQLARLREDPSLIKGAVEELLRYLTIVH
NGLPRVATEDVTLGGRTIRAGEGVLCTLNSANRDEDVFPGGDALDVGRDARRHVAFGFGVHQCLGQPLARVELQIA
VETLLRRLPDLRLGIPFEDVPFRHDMGIYGVHALPVAW

CYP105B3 Saccharopolyspora erythraea NRRL23338

MTSTLDESTPDYPMPRARGCPFDPPPALRDLQRETPMARVRLWDGSTPWLVTRYADQRAV
LRDSHVSADMNHPTYPRQAPGGGTLSFIGMDDPEHARLRRMVGSAFAVKNVERMRPWVQR
IVDEAVDELLAGPRPADLVEEFALPVPSLVICGLLDVPYADHAFFQSNSKTMINRDSTPE
QRSQASGRLAEYLSDLLSSKMDTRGDDLRSRLCGRIEAGDLTLRQATEMAVLLLIAGHET
TANMIALSTLLLLRHPDQLALLRESDDPDVARRAVEEMLRYLNITHGGRRRVALEDVEVA
GQRVRAGEGLVLPNEIANRDPDAFPDPDRLDITREARHHVAFGFGVHQCLGQPLARLELE
IVYRTLYRRAPRLALAAGIEDIPFKHDGFVYGVYELPVTW

CYP105B4 SBI_7395 Streptomyces bingchengensis

59% to CYP105B3 Saccharopolyspora erythraea NRRL23338
VTGAAANTTSGTPLDTPEYNIDRSARCPLDPAPAMRARQAEGPLVRVRLW
DGTLAWLVTGWEEHRALMSDQRVSVDPFRPGAPKLSPGEVTAIDVLKKEG
KRSTGTSFILMDDPEHARLRRMVTSAFTIKRVEALRPPTQRITDDLIDTM
LAGPKPVDLVEALALPVPSLVISNLLGVPYDDHEFFQANSRTIINRETTA
AERAAARGRLVDYLDGLLGEKLAQPREDLLSGLAERIKTGELAREDATEM
GVLMLFAGHETTANMITLGTLALLQHPDQLALLRDTEDPKLIASAVDELL
RYLTITHGGQRRVALADIEIAGQVIRAGEGVIPVNEIANRDPSVFPDPDR
LDLRRDARRHVAFGFGIHQCLGQPLARMELQVVYPTLLRRIPTLALAADL
AEIPFKHDGFVYGAYRLPVTW

CYP105C1 Streptomyces sp.

MTQAAPVTFSTVRENYFGPPAEMQALRHKAPVTRTAFADGRPGW
LVTGYSAARAVLSDSRFTARGEREHPAVPRAATLEDERCRRLIAGQFTARRMRQLTGR
TERIVREHLDAMEHMGSPADLVEHFALPVPSLVIAELLGVPPPDREHFQHDTLRWGGF
GRSTEEVTEAFVSLGGQLQRLVRLKRTEPGDDLLSGLIAADPALTDEELASIAFLLLV
AGHGTTAHQIALGAFLLLEHPDQLAALRADPALTESAVEELLRHLSVVHHGPTRAALQ
DADIEGTPVKAGEVVVVSLGAANRDPARFERPDAVDVTREDTGHLAFGHGMHQCLGRQ
LARIELRVALTALLERFPHLRLACPAAEIPLRHDMQVYGADRLPVAW

CYP105D1 Streptomyces griseus

MTESTTDPARQNLDPTSPAPATSFPQDRGCPYHPPAGYAPLREG
RPLSRVTLFDGRPVWAVTGHALARRLLADPRLSTDRSHPDFPVPAERFAGAQRRRVAL
LGVDDPEHNTQRRMLIPTFSVKRIGALRPRIQETVDRLLDAMERQGPPAELVSAFALP
VPSMVICALLGVPYADHAFFEERSQRLLRGPGADDVNRARDELEEYLGALIDRKRAEP
GDGLLDELIHRDHPDGPVDREQLVAFAVILLIAGHETTANMISLGTFTLLSHPEQLAA
LRAGGTSTAVVVEELLRFLSIAEGLQRLATEDMEVDGATIRKGEGVVFSTSLINRDAD
VFPRAETLDWDRPARHHLAFGFGVHQCLGQNLARAELDIAMRTLFERLPGLRLAVPAH
EIRHKPGDTIQGLLDLPVAW

CYP105D2 Streptomyces griseus

LLIAGHETTANMISLGTFTLLNHPEQLEALRSGRTTTAAVVEEL
LRFLSIAEGLQRLATEDIEVAGTTIREGEGVFFSTSLINRDTEVYENPETLDWDRPSR
HHLAFGFGVHQCLGQNL

CYP105D2 SGR264 Streptomyces griseus

only one amino acid different to partial sequence CYP105D2 highlighted below
MTESTTEPARQDPAPTAPPTQPTSTTPFPQNRDCPYHPPTGYQPLRADRPLSRVTLFDGRPVWAVTGHALARRLLADPRLSTDRTHPDFPVPAERFANVERRRVALLGVDDPEHNAQRRMLIPSFSVKRIAALRPRIQETVDGLLDAMERQGPPSELVADFALPVPSMVICALLGVPYA
DHEFFEGCSRRLLQGPGAADVNEARIELEGYLGALIDRKRVEPGEGLLDELIHRDHPGGPVDREDLVSFAVILLVAGHETTANMISLGTFTLLNHPEQLEALRSGRTTTAAVVEELLRFLSIAEGLQRLATEDIEVAGTTIREGEGVFFSTSLINRDTEVYENPETLDWDRPSRHHLAFGFG
VHQCLGQNLARTELDIALRTLFERLPGLRLAVPAHEIRHKPGDTIQGLLHLPVAW

CYP105D3 Streptomyces sclerotialus

LLIAGHETTANMISLGTYTLLRHPDRLAELRADPGLAPAAVEEL
LRMLSIADGMLRVATEDIEAGGTVIRAGDGVIFGTSVINRDETVYTDPDALDWHRPAR
HHVAFGFGIHQCLGQNL

CYP105D4 Streptomyces lividans

MTDTDTTTNTHPAAPVAFPQDRTCPYHPPAAYDPLRTARPLARI
TLFDGRPAWLVTGHAAARRLLADQRLSTDRTRDGFPATSARLAAVRERRTALLGVDDP
EHRAQRRMVLPEFTLKRAGALRPSIRRIVGERLDAMIAQGPPADLVTAFALPVPSMVI
CALLGVPYADHEFFEEQSRRLLRGPLPADTRDARDRLEAYLGELIDRKRRAPGEGLLD
DLVRRQASEGATDREQLIAFAVILLVAGHETTANMISLGTYTLLTNPGRLAELRADPA
LLPGAVEELMRVLSIADGLLRMATEDIDVDGQTIRAGDGVVFSTSVINRDESVYPEPD
ALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALESLFDRLPTLRLAAPADEIPFKP
GDTIQGMLELPVAW

CYP105D5 Streptomyces coelicolor

3343 MTDTDTTTNTDTTTNT
3295 HPAAPVAFPQDRTCPYHPPAAYDPLRAARPLARITLFDGRPAWLVTGHAAARRLLADQRL 3116
3115 STDRTRDGFPATSARLAAVRERRTALLGVDDPEHRAQRRMVLPEFTLKRAGALRPSIRRI 2936
2935 VGERLDAMIAQGPPADLVTAFALPVPSMVICALLGVPYADHEFFEEQSRRLLRGPLPADT 2756
2755 RDARDRLEAYLGELIDRKRRAPGEGLLDDLVRRQASEGATDREQLIAFAVILLVAGHETT 2576
2575 ANMISLGTYTLLTNPGRLAELRADPALLPGAVEELMRVLSIADGLLRMATEDIDVDGQTI 2396
2395 RAGDGVVFSTSVINRDESVYPEPDALDWHRPARHHVAFGFGIHQCLGQNLARAELEIALE 2216
2215 SLFDRLPTLRLAAPADEIPFKPGDTIQGMLELPVAW* 2105

CYP105D6 Streptomyces avermitilis

MNAALPMFERHDMTETEIRLTGSPAPSFPQDRTCPYQPPKAYEE
RRGESPLTQVTLFDGRPAWLITGHAEGRALLVDPRLSSDWGHPDFPVVVRRTEDRGGL
AFPLIGVDDPVHARQRRMLIPSFGVKRMNAIRPRLQSLVDRLLDDMLAKGPGADLVSA
FALPVPSVAICELLGVPYGDHDFFEECSRNFVGAATSAEADAAFGELYTYLHGLVGRK
QAEPEDGLLDELIARQLEEGDLDHDEVVMIALVLLVAGHETTVNAIALGALTLIQHPE
QIDVLLRDPGAVSGVVEELLRFTSVSDHIVRMAKEDIEVGGATIKAGDAVLVSITLMN
RDAKAYENPDIFDARRNARHHVGFGHGIHQCLGQNLARAELEIALGGLFARIPGLRLA
VPLDEVPIKAGHDAQGPIELPVVW

CYP105D7 Streptomyces avermitilis

MEIGKSKSSPARSFMTEPGTSVSAPVAFPQDRTCPYDPPTAYDP
LREGRPLSRVSLYDGRSVWVVTGHAAARALLSDQRLSSDRTLPRFPATTERFEAVRTR
RVALLGVDDPEHRTQRRMLVPSFTLKRAAALRPRIQETVDGLLDAMEAQGPPAELVSA
FALPLPSMVICALLGVPYADHDFFESQSRRLLRGPGIAEVQDARAQLDDYLYALIDRK
RKEPGDGLLDDLIQEQLNRGTVDRAELVSLATLLLIAGHETTANMISLGTFTLLRHPE
QLAELRAEPGLMPAAVEELLRFLSIADGLLRVATEDIEVAGTTIRADEGVVFATSVIN
RDAAGFAEPDALDWHRSARHHVAFGFGIHQCLGQNLARAEMEIALGTLFERLPGLRLA
APADEIPFKPGDTIQGMLELPVTW

CYP105D8 Streptomyces tubercidicus strain I-1529

VTEAISYFQDRTCPYHPPAGYQPLRETGPLTHVALYDGRKVWAVTGHSEARALLSDQRLSSDRQNPAFPMPFERFA
SIAQVRTPLIGVDDPEHNTQRRMLIPSFSVKRVAALRPDIHRIVDELLDRMLAEGPPAELVSTFALPVPSMVICSL
LGVPYSDHEFFEGESRRLLRSRTAEEAKQARIKLEEYFTDLIAHKEKNPGDGLLDELIEERLRTGTLAHEDLVRLV
MILLVAGHETTANMISLGTFTLLEHPEQLAQLKAEESLMPTAVEELLRFLSIADGMLRVAKEDIEIGGQLIRADDG
VLFPTSLINRDEATYPSPDELDLDRSARHHIAFGFGIHQCLGQNLARAEMEIALRSLFTRIPGLRLAVPAAEIPFK
PGDTLQGMIELPLAW

CYP105D9 Streptomyces sp. JP95

MTDTLDEPQTLADGAEDAPAYPVKRTCPYRMPPGYEELREKGPI
SRVTLWNGRTAWLVTGNDLGRRLFPDARLSSDVLDPRFPLLAPRIEAQRQQAAAPPLV
GVDDPVHARQRRMVLPSFGIRQINALRPEIQKYADDLLDTMLAKGPGVTVDLLTEYAL
PMPSAVICMLLGVPYEDHHYFDERSRHVLSSSGEEQAAQAQQAFTEILAYLDDLIVRK
QAEPGDTLLDELIARQLEEGKVDRQELAMIATVLLVSGHETTSNMIALSTMALLADPD
QLAALRADESLMPRAVDELMRFSSIGDMLMRVAKEDIEIEGHLIRAGDGVILSTMLMN
RDPGAFERPDELDIRRPAGRHVAFGYGIHQCIGQNLARAEMEIALATLFRRVPTLKLA
VPAEQVPVNAPFVLQGVSELPVTW

CYP105E1 Rhodococcus fascians

MAGTADLPLEMRRNGLNPTEELAQVRDRDGVIPVGELYGAPAFL
VCRYEDVRRIFADSNRFSNAHTPMFAIPSGGDVIEDELAAMRAGNLIGLDPPDHTRLR
HILAAEFSVHRLSRLQPRIAEIVDSALDGLEQAGQPADLMDRYALPVSLLVLCELLGV
PYADRDELRDRTARLLDLSASAEQRAVAQREDRRYMATLVTRAQEQPGDDLLGILARK
IGDNLSTDELISIISLIMLGGHETTASMIGLSVLALLHHPEQAAMMIEDPNCVNSGIE
ELLRWLSVAHSQPPRMAVTEVQIAGVTIPAGSFVIPSLLAANRDSNLTDRPDDLDITR
GVAGHLAFGHGVHFCLGHSLARMTLRTAVPAVLRRFPDLALSPSHDVRLRSASIVLGL
EELQLTW

CYP105F1 Streptomyces lavendulae

MSDTEQHAPTLPRQRTCPFSPPPELEELRRTDPISRMRFADDSP
GWLLTRHADVRAALADPGVSSHPGKAPQPWRNLAPEMRAEHYLPGFLIFMDPPDHTRY
RRLLTKWFTMRAIRKLEPRIEQIVTETLDAMEAQGGTVDLVQSFALPIPLLVICELMG
IRYEEREEFMDMVLRLQALDATPEELGALGARMNEFMMKLAAAKRANPGDDLLSHLAH
DPDADPALTDLEIAGIGVLMLIAGHETSANMLGVGTYTLLENADQWALLRDDISLIDR
AVEELLRHQTIVQQGLPRGVTRDMEIAGHQVKTGESLLASLPAANRDPAVFPDPDRLD
ITREHNPHLAFGHGIHLCLGMELARVEMRQAWRGLVTRFPGLRMAAAPEDIRWRDDQI
VYGVYNLPVTWDEAK

CYP105F2 Streptomyces peucetius

VSETDQRPPTLPRQRTCPFSPPPELEELRGTDPISRMRFADDSEGWLLTRHADVRAALAS
RSVSSHPGRTPQPWRNLAPEMRAEEYLPGFLIFMDPPNHSRYRRLLTKWFTMRAIRKLEP
RIEQIVSDALDAMEAEGGPVDLVQSFALPIPLLVICELMGIRYDDRVEFMDMVLRLQDLE
ATPEELGALGAKMNQFMIDLCAAKRKNPGDDLLSHLIQDPDAEPALTDLEVAGIGVLMLI
AGHETSANMLGIGTYTLLQNPGQWDLLRNDIGLIDQAVEELLRHQTIVQQGLPRGVTEDM
EIAGHAIKPGETLLASLPAANRDPEVFPDPDRLDITREHNPHLAFGHGIHLCLGMELARV
EMRCAWRGLVKRFPDLRMAARIEDIPWRDDQIVYGVYKLPVTWGDAP*

CYP105G1 Amycolatopsis mediterranei

MTTKVTENAPSTESLRSPLPPEFVRREDPFHVPPALVAVSERGP
VARATLAAGDPFWLVSGYEEARAVLSDPRFSSDRFQYHPRFKELSPEFAFPAPSLMIC
ELLGVRYEDRAEFQQRASALLQMNAPVAEAVKNADALRAFMQALVTDKRANPAGDIIS
GLIHHAGADPALTDDELINIANLLLIAGYDTTASMLGLGIFVLLQRPAQLATLRDDPS
RIADAVEGLLRYLSVVNPGIFRFAKEDLEFAGEHIPAGSTVVVSVVATNRDARHWPDP
DLDLTRPRGPHLAFGHGVHQCLGQQLARMEMQAGYAELLRRLPNVRLAVPPEEVPLRN
DMLTYGVHSLPIAWDAP

CYP105H1 Streptomyces noursei ATCC 11455 nyst

MSTEADARTAAPQCPVAFPLRRPGRPFPPPEYATYRGGAGLVRS
ELPSGPVWLVTRHEDVRAVLTDPRISADPSKPGFPKAGRTGGAPSQYEVPGWFVAMDP
PEHGRFRKTLIPEFTVRKVRELRPVIQQIVDERIDAMLAAGTSADLVESFALPVPSLV
ISSLLGVPKVDRDFFEDRTRVLVRLSSTDEERDKATQALLRYLGRLIQIKQRRPGDDL
ISRLIAAGTLSRQELSGVAMLLLIAGHETTANNIGLGVVQLLTNPRWIGDDRIVEELL
RYYSVADLVAFRVAVEDVEIGGQLIRAGEGIVPLIAAANHDATAFAAPSEFDPERSAR
SHVAFGYGVHQCLGQNLVREEMDIAYRTLFARIPSLTLAVPVEELPLKYDGVLFGLHE
LPVTWK

CYP105H2 Streptomyces albus

LLIAGHETTANNIGLGVVTLLSHPQWAGDERAVEELLRLHSVAD
MVALRVAVDDVEIAGQVIRKGEGIVPLLAAANHDTEVFGCPHAFDPERSERRHVAFGY
GVHQCLGQNL

CYP105H3 Streptomyces natalensis

MTYTDPAAPETDPPAVDFPQRKPGVPFPPPDYADYRDRKGLVLS
QLSDGKRVWLVTRHEDVRAVLTSPSISSNPEHKGFPNVGNLGVPKQDQIPGWFVGMDS
PEHDRFRKALIPEFTVRRVRAMKPAIERTVDAQLDAMLAAGNTADLVADFALPIPSLV
ISALLGVPPADREFFESRTRVLVSLRSSTDDDRMAAAKDLLRYINRLVEIKQKWGGDD
LITRLLATGAIAPHEMSGVLMLLLIAGHETTANNIALGVVTLLANPQWIGDDRAVEET
LRFHSVADLVSLRVAVQDVEIAGQLIKAGEGIVPLVAAANHDENAFECPHAFDPSRSA
RHHVAFGYGVHQCLGQNLVRIEMEVAYRKLFERIPNLELAVPTDGLDIKYDGVLYGLN
ELPVRW

CYP105H4 Streptomyces nodosus

MTAETEMTTFAPGCPVAFPLRRPGRPFPPPEYADYRAGEGLVRS
ELPASGPVWLVTRHEDVRTVLTDPRISADPSRPGFPRARRTGGAPSQSEIPGWFVALD
PPEHDRFRKTLIPEFTVRKVRELRPAIQQIVDERIDALLAAGNSADLIADFALSVPSL
VISDLLGVPKADRDFFEAKTKVLVTLSSTDEQRDEASKALLRYLNRLIQIKGRRPGED
LISRLLQAGTMNRQELSGVSMLLLIAGHETTANNIGLGVVQLLTNPQWIGDDRIVEEM
LRYYSVADLVSFRVAVEDVEIGGQLIKAGEGIVPLIAAANHDGSVFDKPEEFNPERSA
RSHVAFGYGVHQCLGQNLVRVEMEIAYRTLFERIPTLELAVPVEELPLKYDGVLFGLH
ELPVTWS

CYP105H5 Streptomyces griseus

MTTSPGPTVVDFPRRTPREPLPLSQYAEHRKQNGLVQTHLPNGR
PIWLVTRHEDVRAVLTHPRISANPDNEGFPNVGETMGVPKQEQIPGWFVGLDSPEHDR
FRKVLIPEFTVRRVRELRPAIERTVDERIDAMLAGGNTADLVNDFALPVPSLVISALL
GVPSADRDFFESRTRTLVAIRTSTDEERAEATRQLLRYINRLIVIKKKWRGEDLISRL
LSTGKLSDEELSGVLLLLLIAGHETTANNIGLGVVTLLSHREWIGDDRLVEELLRLHS
VADMVALRVAVDDVEIAGQTIRKGEGIVPLLASANHDTEAFGCPHAFNPERTERRHVA
FGYGVHQCLGQNLVRVEMEIAYRKLFERIPELRLAVPEDQLAYKYDGILFGLHELPVR
W

CYP105H6 SBI_4165 Streptomyces bingchengensis

67% to CYP105H4 Streptomyces nodosus
VGSVKMATADAIPIEFPRRQPGRLTPPAEYAGLRSQEGLVKSSLPGGSTV
WLVPRHEDVRSVLTDPRISSNPLHEGFPSMGKNGTVPPPDQVPGWFVAYD
PPEHGRFRKALIPEFTVRRIKEMQPAIQRIVDRLIDALLDGGNSADLVAQ
FALPVPSLVICELLGVPYSDHEYFESRTRVLVTFTSTDEQRESAAKELIT
YLTKLISIKHKFPGNDLISGLLKNETLTAQEVSGIALLLLIAGHETTANN
IALGVVMLLLNREWIGDPRAVEEALRYLSVADRVALRVAVEDVEIGGQLI
KAGEGIVPLGAAANHDENAFERADQFDPGRPARHHVAFGYGVHQCLGQHL
VRAEMGTAYRTLFERIPTLRLAVPPEELPFKDEGILFGLHELPVTW

CYP105J1 Amycolatopsis mediterranei rifamycin

MTETVAFPQDRTCPYQPAPGYEPLADRRPIAEVTLYDGRKAWAV
TGHELARKLLCDPRISSDRTNPAWPMVSAAAAVEFTDVQQKVIKLLTALVGVDGPAHR
ARRKLVQAGFTVKRIDSLRPKIQALVDRQIDEMIAEGAPVDLLKKFASPVPLIALCDL
LGIPHEDQDYFEKKAHQILFGPDAGGAYDELMAYLTKLIDKAEQNPGEEGFLQALLAE
RDPSSDVDHEEILQMFLIVLVTGHDTTSSSIGLGAFTLLQHPERLAELRADPSLMPAA
VDELTRFVVVPDGLQRVAADDIEVDADTTIRKGDGVFFLFSLINRDEEAYEDGDRLDW
HRPTFRDHLTYGFGTHQCAGMNHARAIMEIAFRRLIDRLPGLRLAVPADEVRVKPGDA
FQGLAELPVTW

CYP105K1 Streptomyces tendae strain Tue901

MTETFGHDIPSFPMARECPMHPPAEYRKLRVQEPVSRVRMPDGQ
VAWLVLKHDLARKLLADPRVSADRLHPAFPGRLTAEQRTATERVRRLSTRRSMIHLDG
DEHGAHRKILTGEFSLRRIAALRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIRERAAASDALNDFLEDLVTEKERGEPTDD
LIGRLIARNRRTPVMTHDEIVGTAVMLLIAGHQTTANMISLGVVALLENPEHKARIAA
DPSLLPPAIEEMLRYFSVVENAPARVATEDIEIGGVTIRKDEGIVVSGLAADWDDEVF
EHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC

CYP105K2 Streptomyces ansochromogenes

MTEAFDHDIPSFPMARECPMHPPAEYRELRGQEPVSRVRMPDGQ
VAWLVLKHALARKLLADPRVSADRLHPAFPGRLTAEQRAATERVRRLTTRRSMIHLDG
DEHGAHRRILTGEFSLRRIAAQRPRVQEIVDRSIDEMLAAPQPADLVEHVSQAVPSLV
ICELLGVPHEQRRDFHEWAGMLVSRSVSIQERAAASDALNDFLEALVTEKERGEPADD
LIGRLIARNRQTPVMTHDEIVGTAVMLLVAGHQTTANMISLGVVALLENPEHKARIAA
DSSLLPPAIEEMLRYFSVVENAPARVATEDIAIGGVTIRKNEGIVVSGLAADWDDEVF
GHPDRLDFERGARHHVAFGYGVHQCLGQNLARVELEIVFETLLRRVPGLSLAVPAEEL
PYKDDAGIYGIYRVPVNC

CYP105L1 Streptomyces fradiae

MSSSGDARPSQKGILLPAARANDTDEAAGRRSIAWPVARTCPFS
PPEQYAALRAEEPIARAELWDGAPVWLISRQDHVRALLADPRVSIHPAKLPRLSPSDG
EAEASRSLLTLDPPDHGALRGHFIPEFGLRRVRDVRPSVEQIVTGLLDDLTARGDEAD
LLADFALPMATQVICRLLDIPYEDRDYFQERTEQATRPAAGEEALEALLELRDYLDRL
ISGKTGRESGDGMLGSMVAQARGGGLSHADVLDNAVLLLAAGHETTASMVTMSVLVLL
QHPTAWRELTVNPGLLPGAVDELLRYLSIADGLRRSATADIEIDGHTIRAGDGLVFLL
AAANRDEAVFSEPEAFDIHRSARRHVAFGYGPHQCLGQNLARMELEVALGAVLERLPA
LRPTTDVAGLRLKSDSAVFGVYELPVAW

CYP105L2 Micromonospora griseorubida

MDRTCAWALPEQYAEFRQRATGWPAKVWDGSPTWLVSRYEHVRA
LLVDPRVTVDPTRQPRLSEADGDGDGFRSMLMLDPPEHTRLRRMFISAFSVRQVETMR
PEIEKIVDGILDRLLALEPPVDILTHLALPMSTQVICHLLGVPYEDREFFQERSELAS
RPNDDRSMPALIELVEYLDGLVRTKTAHPDTGLLGTAVTERLLKGEITHQELVNNAVL
LLAAGHETSANQVTLSVLTLLRHPETAAELREQPELMPNAVDELLRYHSIADGLRRAA
TADIVLGDHTIRAGDGLIILLSSANHDGNTFGAEATFDIHRPARHHVAFGYGPHQCLG
QNLARLEMEVTLGKLFRRVPALRLAQEPDALRVRQGSPIFGIDELLVEW

CYP105M1 Streptomyces clavuligerus clavulanic

MNEAAPQSDQVAPAYPMHRVCPVDPPPQLAGLRSQKAASRVTLW
DGSQVWLVTSHAGARAVLGDRRFTAVTSAPGFPMLTRTSQLVRANPESASFIRMDDPQ
HSRLRSMLTRDFLARRAEALRPAVRELLDEILGGLVKGERPVDLVAGLTIPVPSRVIT
LLFGAGDDRREFIEDRSAVLIDRGYTPEQVAKARDELDGYLRELVEERIENPGTDLIS
RLVIDQVRPGHLRVEEMVPMCRLLLVAGHGTTTSQASLSLLSLLTDPELAGRLTEDPA
LLPKAVEELLRFHSIVQNGLARAAVEDVQLDDVLIRAGEGVVLSLSAGNRDETVFPDP
DRVDVDRDARRHLAFGHGMHQCLGQWLARVELEEILAAVLRWMPGARLAVPFEELDFR
HEVSSYGLGALPVTW

CYP105N1 Streptomyces coelicolor

MTPPESPTASHTPGATPPRDFPIQRGCPFAAPAEYAALRTDDPV
ARVTLPTRREAWVVTRYDDVRELLSDPRVSADIRRPGFPALGEGEQEAGARFRPFIRT
DAPEHTRYRRMLLPAFTVRRVRAMRPAVQARVDEILDGMLAAGGPVDLVSAYANAVST
SVICELLGIPRHDLEFFRDVTRISGSRNSTAEQVSEALGGLFGLLGGLVAERREEPRD
DLISKLVTDHLVPGNVTTEQLLSTLGITINAGRETTTSMIALSTLLLLDRPELPAELR
KDPDLMPAAVDELLRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQ
FDDPERVDFHRTDNHHVAFGYGVHQCVGQHLARLELEVALETLLRRVPTLRLAGERDQ
VVVKHDSATFGLEELMVTW

CYP105N2 Streptomyces glaucescens cytochrome P450

LLIAGHETTTSMIALSTLLLLDRPELPAELRNDPDLMPAAVDEL
LRVLSVADSIPLRVAAEDIELSGRTVPADDGVIALLAGANHDPEQFDDPERVDFHRTD
NHHVAFGYGMHQCLGQNL

CYP107N3 SP0881 91% to 107N1 AJ605544.1

VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW
LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT
PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT
WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE
LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV
DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP
HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*

CYP105P1 Streptomyces avermitilis

MPEPTADAPTVPKARSCPFLPPDGIADIRAAAPVTRATFTSGHE
AWLVTGYEEVRALLRDSSFSVQVPHALHTQDGVVTQKPGRGSLLWQDEPEHTSDRKLL
AKEFTVRRMQALRPNIQRIVDEHLDAIEARGGPVDLVKTFANAVPSMVISDLFGVPVE
RRAEFQDIAEAMMRVDQDAAATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDP
DGVVDDMFLMNAAGTLLIAAHDTTACMIGLGTALLLDSPDQLALLREDPSLVGNAVEE
LLRYLTIGQFGGERVATRDVELGGVRIAKGEQVVAHVLAADFDPAFVEEPERFDITRR
PAPHLAFGFGAHQCIGQQLARIELQIVFETLFRRLPGLRLAKPVEELRFRHDMVFYGV
HELPVTW

CYP105P2 Streptomyces peucetius

MSQPTAGAPAAPKARSCPFLPPDGIADIRAAAPVTRATFTSGHEAWLVTGYEQVRAVLRD
PSFSVGVPHALHTQDGVVTQKPGRGSLLWQDAPEHTDDRKLLAKEFTVRRMQALRPNIQR
IVDEHLDAIEARGGPVDLVKTFANPVPSMVISDLFGVPAERRAEFQEIAEAMMRVDQDAA
ATEAAGMRLGGLLYQLVQERRANPGDDLISALITTEDPDGVIDDMFLMNAAGTLLIAAHD
TTACMIGLGTALLLDRPDQLALLQKDPSLIGNAVEELLRYLTIGQFGAERVATQDGEIGG
VRIAKGEQVVTHLLSADFDPAFVEDPERFDITRRPAPHLAFGFGAHQCIGQQLARIELQI
VFGTLFRRFPTLRLAKPVEELRFRNDMVFYGVHELPVTW

CYP105Q1 Streptomyces avermitilis

MADALAGRAPDATPPVAAYPMPRAVSCPLAPPPALQPLRDEQPI
TKVRIWNGSTPWLITRHADQRALLTDPRVSNDDRDPGFPYVNAHRAEIAHATPRLITN
TDAPEHTRLRRTVNAPFLIKRIEAMRPAVQRIVDGLIDDMLDGPNPADLLTALALPVP
SLVIAQLLGVPYADHEFFQRNSNLVLDNSVPAEEARAASGALAAYLDTLLAEKTAAPD
ADVLSEMGGRIKAGEMTHREAVHMGVAMLIAGHETTATMISLGTLALLEHPEQLAVLR
DAEDPKVIAAAVEELLRYLTIVHSGIRRVAKEDIEIGDRVIGAGDGLLFDLHAANWDS
EAFPEADRLDLSRPARHHQAFGYGPHQCLGQSLARLELQVVYGTLYRRFPTLRLAAPI
DRLAFHHTGTTYGVRCLPVTW

CYP105Q2 Streptomyces sp.

LIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHSGLRRVA 182
183 KGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGFGTHQC 350

CYP105Q3 Streptomyces sp.

MADTLTDAAPDTDGRVPEYPMPRATGCPLAPSPAAAELRGDRPITRVRIWNGSTPWLITR 318
319 HADQRTLLTDPRVSNDDHEPDFPHVNAHRAAIAPHTPKLITNTDAPEHTRLRRSVNAPFL 498
499 VKRIEAMRPAVQKIVDDLIDDMLAGPSPADLLTALALPVPSLVIAELLGVPYEDHHFFQE 678
679 NSNRVLDNSLTAEEAQESSRALGGYLDTLFRTKLEQPGEDVLSEMGSKVKAGEMTHQEAV 858
859 SMGVAMLIAGHETTATMISLGTLALFEHPDQLAVLRDTEDPKVVAGAVDELLRYLSIVHS 1038
1039 GLRRVAKGDIEIDGRLIRKGDGLLFDLQTANWDPNAFPGAERLDLARPARQHNAFGYGPH 1218
1219 QCLGQNLARLELQVVYGTLYRRVLTLRPAVPVDQLAFNHTGTTYGVKCLPVTW 1377

CYP105Q4 Mycobacterium marinum MM4762

MSDTLASPSP ETASGIPDYP MSRSAGCPFA PPPGVMALAA AKPLTRVRIW DGSTPWLITG
YEQVRELFSD SRVSVDDRLP GFPHWNAGML STVHKRPRSV FTADGEEHTR FRRMLSKPFT
FKRVEALRPT IQQITDEHID AMLAGPQPAD LVAKLALPVP SLVISQLLGV PYEDAEMFQH
HANVGLARYA TGADTVKGAM SLHKYLAELV EAKMANPAED AVSDLAERVK AGELSVKEAA
QLGTGLLIAG HETTANMIGL GVLALLVNPD QAGILRDAQD PKIVANAVEE LLRYLSIIQN
GQRRVAHEDI HIGGETIRAG EGIIIDLAPA NWDAHAFTEP DRLYLHRAGA ERNVAFGYGR
HQCVGQQLAR AELQIVYRTL LQRIPTLTLA TALEDVPFKD DRLAYGVYEL PVTW*

CYP105Q4 Mycobacterium ulcerans

VSDTLASPSPETAAGIPDYPMSRSAGCPFAPPPGVMSLAAAKPLTRVRIWDGSAPWLITG
YEQVRELFSGSRVSVDDRVPGFPHWNAGMLSTVHKRPRSVFTADGEEHTRFRRMLSKPFT
FKRVEALRPTIQQITDEHIDAMLAGPQPADLVAKLALPVPSLVISQLLGVPYEDAEMFQH
HANVGLARYATGADTVKGAMSLHKYLAELVEAKMANPAEDAVSDLAERVKAGELSVKEAA
QLGTGLLIAGHETTANMIGLGVLALLVNPDQAGILRDAHDPKIVANAVEELLRYLSIIQN
GQRRVAHEDIHIGGETIRAGEGIIIDLAPANWDAHAFTEPDRLYLHRAGAERNVAFGYGR
HQCVGQQLARTELQIVYRTLLQRIPTLTLATALEDVPFKDDRLAYGVYELPVTW

CYP105Q5 Streptomyces scabies SCAB11341

MAGTPTDAAS GTDGQLPEYP MPRAAACPLA PPPAAAGLRG EHPISRVRIW NGSTPWLITR
HADQRTLLTD PRVSNDDHEP DFPHVNAHRA AIAPHTPKLI TNTDAPEHTR LRRSVNAPFL
VKRIEAMRPA AQKIVDDLID EMLAGPNPAD LLTALALPVP SLVIAELLGV PYEDHRFFQE
NSNRVLDNSL TAEEAQESSR ALGGYLDTLF RTKLEQPGDD VLSEMGAKVR AGEMTHQEAV
SMGVAMLIAG HETTATMISL GTLALFEHPD QLAVLRDTEE PRVVAGAVDE LLRYLSIVHS
GLRRVAKDDI EIDGRVIRKG DGLLFDLQTA NWDPNAFPEA ERLDLGRPAR QHNAFGHGPH
QCLGQNLARL ELQVVYGTLY RRVPTLRPAV PVDRLAFHHT GTTYGVTCLP VAW

CYP105Q6 Mycobacterium vanbaalenii PYR-1

MTETLAQEAVSVPEYPMERTAGCPFAPPQQMLEMNQVKPLSRVRIWNGTTPWLVTGHEVARTLFADSRVS
VDDRREGFPHWNEHMLSTVDKRPRSVFTSDAEEHTRFRRMLSKPFTFRRVEALRPVIQQVTDECIDEILA
GPQPADMVAKLALPVPTRVISDMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLHQYLINLVEEKQ
AHPAEDAVSDLAERVTAGEISVKEAAQLGTGLLIAGHETTANMIGIGICALLENPEQAALLRDSDDPKFI
ANAVEELMRYLSIIQNGQRRVATEDIEIGGETIRAGEGIILDLAPANWDARAFPEPDKLDLTRDATQQLG
FGYGRHQCVGQQLARAELQIVFHTLLRRIPTMKPAIPLEEVPFKHDRLAYGVYELPVTW

CYP105Q7 Mycobacterium smegmatis

MSETLTQPSATDIPGYPMERAAACPFAPPPQMLDMNKAKGLSRVRIWDGS
TPWLITGHEEARALFADSRVSVDDRRPGFPHWNEHMLATVHKRPRSVFTS
DAEEHTRFRRMLSKPFTFRRVEGLRPAIQKITDECIDAILAGPQPADIVD
KLALPVPTVVISEMLGVPYEDHEFFQEHANAGLARYAAADAMQKGAMSLH
QYLIDLIEKKQAEPAEDAVSDLAERVTAGELSVKEAAQLGTGLLIAGHET
TANMIGIGILALLENPEQADFLRNAEDPKVIANAVEELMRYLSIIQTGQR
RVAVEDIEIGGETIKAGEGIIIDLVPANWDAKAFPEPDKLDLTRDAGQQL
GFGYGRHQCVGQQLARAELQIVFHTLLRRIPTLRLAIPLEEVPFKHDRLA
YGVYELPVAW

CYP105R1 Streptomyces avermitilis

MTQTAAVTTAWPLHRTCPMSQPPALAAFRDGPPRQVLLRGDQPA
WLITRYADVRQALADPRLSVNDQHPNWPNRLLFPVPPRAVSFWRMDPPEHGAYRKMVA
AEFIAHRTQALRPLLQSITDELLDEMAAMPKPVDFHSVFALPLPCIAIARIFGVPDED
MSEFKENTSALLNQKEPEKAVQAFLATTAYLDGLARAKEREPKDDLLSRLVVNFVRPG
QLSHDDLVAMVRLMLVAGHETTANQIALSIFTLLDRPGVLAELRADPRLLTPVVDELL
RYWSIAQDNVVRTATEDLSVGDARIAAGDAVVISVPGANHDEAVFPDAADFDIHRDNS
RHLAFGHGPHFCPGGPLARTELEIAITSVFRRFPDLRLAIGRDQVPVHTDTLVYGLEC
LPVTW

CYP105S1 Mycobacterium smegmatis

MTQAQALPPLHIRRDAFDPTPELGEIRAGEGVHVTVNPFGMQVYLVTRHE
DVKTVLSDHERFSNSRPPGFVLPGAPQISAEEQASNRAGNLLGLDPPEHQ
RLRRMLTPEFTIRRIKRLEPRIVEIVDAHLDAMESAGPPADIVADFALPI
PSLVICELLGVPYEDRTDFQQRSARQLDLSAPMPERLELQRQGRAYMRGL
VERSRTRPGDDILGMLVREHGTELTDDELIGIAGLLLLAGHETTSNMLGL
GVLALLRHPDQLACVRDDPDAVGPAIEELLRWLSIVSTALPRITTTDVEL
AGVTIPAGHLVFASLPAGNRDPEFIDDPDTLDIRRGAPGHLAFGHGVHHC
LGAPLARMEMRIALPALLRRFPTLALAEPFEDVRWRPFHFIYGLQSLAVAW

CYP105S2 Mycobacterium vanbaalenii PYR-1

MSQAVRPELPPVHMRRDGFDPTPQLREIRETEGVRVITSAFGMSAYLVTRHEDVKTVLSDHTRFSNTRPP
GFVVPGAPPIDEDEQARSRAGNLLGLDPPEHQRLRRMLTPEFTLRRMRRLQPRIAEIVDAQLDALAAARD
GEASADLVQHFALPIPSLVICELLGVPYADRDDFQRRSARQLDLSIPIPERIELAREGRAYMGSLVAGAR
TNPGDDILGMLVREHGAELTDDELVGIAGLLLLAGHETTSNMLALGTLALLRHPEQLAAVREDPDAVAPA
VEELLRWLSIVHTAIPRITTTDVEIAGVSIPAGQLVFASLPSGNRDDEFIERPEVFDITRGAMGHLAFGH
GVHHCLGAPLARMEMQIAFPALLRRFPTLAPAGEFDDVPFRSFHFIYGLKSLEVTW

CYP105S3 Frankia alni ACN14a

MRRAQFDPISELSTARDTVGVCPVVTPFGVPAHLVSRYDDVREVLSDSVRFSTADRHALMPPDAAGPTEQ
EYAQARVGNLLAYDPPEHTRLRRMLTPEFTMRRMRALEPRIVDIVSAALDDVERAGRPADLVSTFALPVP
SLVICELLGVPYADRAEFQRRTVDQLDASHPPEHRLALQQASRAYMATLVERARRDPGEDILGMLVREHG
DDISAEELVGIASLLLLAGHETTANMLGLGTLALLRHPDQLARVRDDPASVEPAVEELLRWLSIVHAGIP
RTATTEVTIAGSTIAAGEHVVLALPGANRDPALVDDPDRLDITREPAGHVAFGHGLHHCLGAPLARLELR
IAYPALLRRFPGLALAVPYEQIAFRPYSVIHGLQALPVTW

CYP105S4 Frankia sp. CcI3

MAAAPIVPLHIRRAQFDPIEELVRIRDTDGVCRVVTVFGIPAYLVSRYEDVREILADPGRFSNVNQWVVG
PGGPVLSDEEIAELRAGQMLAFDPPDHTRLRRMLTPEFTVRRMRGLEPRIRDIVDAALDEVERAGRPADL
VATFALPVPSLVICELLGVPYSDRAEFQQRTRRQIDASLPIEQRLALQREARAYMAGLVTRAQAAPGEDL
LGMLVREHGDELSTAELVGIASLLLVAGHETTSNMLALGTLALLRHPDQLAMVRDDPAQVEPAVEELLRW
LSIVPSGVPRTTTTEVEIAGHRIPAGEQLLLALPAANRDPALVGDPDRLDITRGAPGHVAFGHGVHHCLG
APLARMEMRIAFPALLRRFPDLALAVPYEQVAFRAHHVVHGLHALPVTW

CYP105T1 Burkholderia fungorum

MRKTMTSAINDVRPQTTSTFPFARTGSPLHPPAEYARYRDGQPV
TRVQMWDGRYAWIFTRMEDVKAVLSSPHFSVVPSKPGYPFLTPARAATVKSYQTFITM
DPPDHTRFRRMLTRDFTQKRMEELRPQIAAYVNRLIDEMLARGSPGDLVSALALKLPV
TVVSMLVGVPYEDHEDLVKWSGQRLDLEQNPTVSESAADNMLAYFDGLLQRKERDPGD
GADMLSRLVIEQIKPGHLSRLEAIHMVNLLYFAGHETTANQIALGTLSFLLDPRQRAL
LENNPGLLKNAIEEMLRFHTISHYNSCRVATADVEVGGTLIREGEGAYALIMAANRDP
AAFPAPDRFDIERPNSQEHVAFSYGLHMCLGQPLARLELQVCFEALFRRLPRLRLAVP
LEELPFKREMYVYGLHALPVTW

CYP105U1 Streptomyces hygroscopicus strain NRRL 3602

MDEIRDYPESRAAACPFSPPLGYEELRERSAVTRVRMWDGSTPF
LVTGYHEARAALGDSRFSADGTHKAMPRFVKFEVPAEVFNLGRMDDPEHARIRRMLTA
NFTIRRTEAMRPMIQGIVDGLLDRLIAQGPPADLVADFAFPLPSQVIGVMLGVSDADF
AEFQQASQGVMDFTASAEEMGAALGVMVDYVARMCAAKRADPGDDLLSRLIVDQELTG
GLTQQQVVATALVLLLAGHETTANMIALSTVLLLSHPEQLARLRADAGLMGNAVDELL
RYITIVQEGTGRVATEDVEVGGVLIPGGEGVIINLPSANRDPHFADAHELDLSRPNAR
EHVAFGFGVHQCLGQTLARVELQIALETLLRRLPTLRLEVPFDDLAFLYESMNFGVAR
VPVAW

CYP105V1 Streptomyces sp. HK803

MSQLSSELPAFPMSKAKGCPLDPPPEYAQLRSDRPVAKARLWDG
KEVWLITGYDEIRSIFTDPRISVDNTQPGYPWLSEQARTVVLTGGVKPVGRMDPPEHT
AMRRMLGQGFLVKKIQNMRGDVEALVNELIDDILAGPRPTDLVPSLAMPVPSTALGWV
LGVPPADKRLISLVPRLFDEDSGLEGAMEARAELFAYIDELITHRENQPGDDIISHLV
GYYQKGELSRVSVLTQSVTLIAAALDTTRSMITNGILALLQHPEQAAALIEDPDLVPA
AVEELLRYTVVTEFSSKRVAAADIEIAGETIKAGDGIICLISAGNRDEKVFTDPDTLD
VRRDAKQHLGFGAGIHTCIGKQLARMELEVVYGTLFRRIPELRLAVPFDQLVFRNTFD
VQGVRALPVTW

CYP105W1 Micromonospora echinospora

MPRRCPFGPPAEYARLRTERPVARLPMLGGNTAWVVSRYADVKR
VLSDPRMSADRRRAGFPRFAPTTESQRQASFANFRPPLNWMDPPEHTAARRQIVDEFA
ARRVRQLRPLVERVVDEHLDAMTAGRSSADLVPSFSYPVPSRVICEMLGVPYGEHAFF
ERRSTRMLSRGVPADERARCAREIREFLDGVVTDKERHPGDDVLSRLLAAQRAAGEPD
HEAVVSMAFVLLVAGHVTTSNMISLSVLALLTHPERLARLRAEPDRFPAAVEELLRYF
TIVEAATARTATADVTVGGVTIRAGEGVVALGQAANRDPAAFDRPDEFDPDRDARHHL
AFGYGRHICPGQHLARLELDVALSRLVRRLPGLRLTVDVDDLPLKEDGNIFGLHALPVAW

CYP105X1 Pseudonocardia autotrophica same as Amycolata

MAEDTLGQDFPMQRQCPFEPPKEYERLRAEQPISRVRMPDGTPA
WLVTLHEDVRTVLASPAFSSDLAHPGMPAVNPEIRTIARQQRPPFSRMDPPEHSFFRR
MLIPEFTVKRTKTLRAGIQSVVDGLIDDLLRKSPPVDLVDEFALPVPSLVICQLLGVP
YSRHEFFQQQARVILSRQSTREQVGAAFTALRAYLDTLVEEKLHTPGDDLTSRLATEH
LEPTGDVRRQDLVASCMLLLTAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEA
VEELVRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDI
HRGNRRHACFGYGVHQCIGQHLARTELEVAFSTLFTRIPTLQIAAPSDELDYDHDGML
FGLHELPVTW

CYP105X2 Amycolata autotrophica same as Pseudonocardia

LLIAGHETTSHMISLGVTALLERPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL

CYP105X3 Micromonospora inyoensis

LLIAGHETTSHMISLGVTALLEHPDQLAALQNDLTLLPEAVEEL
LRYLSIADYVPSRVALEDVVIGGTVIRAGEGVVPLLAAADWDPKVFDNPGTLDIHRGN
RRHVAFGYGVHQCLGQNL

CYP105Z1 Streptomyces scabies SCAB17851

MTTHPPHPPL PTLRPLLDPS PEYAKWRTEE PIRRVTIWGD NSPWLITRHE DARVVLADPR
FSADATRDGF PGFRPQSPPR GPGQFFMMDP PDHTRLRRVL IPDFTFRRIE QLRPAIARIC
GELLDAMTAD DATAADLVEA YALPLPSLAI CELLGVPYED HDFFQRQANA FSSFSSGPEE
MMAARTALHT YLGDLLARRG REPADDLLTR LARDRVATGE ISAPEAVGIA SLLLVAGHET
TANMFPLAVL DLLRHPAQLA ALRADPALWP GAVEELLRHL TVTHAGLRRI ATEDVVVSGV
RIRAGEGVIV ALQAANRDPS AFTAPDTLDV RRTTTGHLAF GHGLHQCIGQ SLARAELQVG
LPALFDRLPG LRTAGEPEDF TPAISAVHGV RSLPVSW

CYP105AA1 Streptomyces tubercidicus strain R-922

MTGRSACGSGARSAPSVRTPASPPVGPSAAPVTPVTPSQPLTLL
EKDCPMTAMQPTARTQPMERTCPFSPPEGYRTLREEDPITQVTFPDGAKGWLVSRYSD
VRAVLADPRFGANGQQPPLPGMFLTMDPPEHTRFRRLLTGQFTVRRMRKLAPAVEQIV
AERLAEMAAAEGPVDLVQAFALPVPSLVICELLGVPYADREEFQENSSRMLRLDASQE
QFEQAQMAMYERIHQLVVAKRAHPTDDILSGLVQSGVLTDEEVTGVGVLLLIAGHETT
ANMIALGTMCLLGHPGQLASLRADPELMDDAVEELLRYLTIVQYGLRRMALEDVELGG
QRIKAGSVVVAALPSGNRDATHFSGDPETLDVRRPYSPHLAFGHGVHQCIGQQLARVE
MKAALSALIDRFPGLRLAVPAREVPMRDDMLIYGVHELPVTW

CYP105AA2 Streptomyces tubercidicus strain I-1529

MTRTVPGPQALPTERDAGPFAPPRDISRMREARPVSPMVFPDGH
EGWIVTGYDAVRRLMADTRFSSRQDIGILHVPYETPGMPAPTEPSPQIPGLFIAMDPP
DHTRLRRKLTGAFTVKRMKQLEEHISDIVERQLDELTRLAPPVDLVKEFALPVPSLVI
CALLGVPYADRETFQVNSAKFLEKDVSLDEKMAAYTGLTTYLSELVTRKRAAPGEDIL
SDLARHDDLTIEELTGMAFLLLLAGHETTANMLALGTFALLEHPEQLAELRADPDLMP
GAVEELLRYLSIADIFYRYATEDIELGGETIGKGSTVVVSLLAANHDPQRFDNPDTLD
IHRTARGHLSFGHGIHQCLGQQLARIEMRAGFEGLLRRFPTLELAIPADEVKLKTDMN
IYGVHELPVTWTDTAR

CYP105AA3 = old CYP105Y1 Rhodococcus sp. RHA1 Rha04313

MSKTVAVPYGLPMERDAGPFDPPRRITRLRETRPVSPMVFPDGHEGWLVTGYDAVRQLMADTRFSSRQDIGILHVPYETPGMPAATEPSPQMPGVFIAMDPPDHTRMRRKLAGAFTVKRMKQLEDHIIDVAERQLDAMARLTPPVDLVKEFALPVPSLVICELLGVPYADRDNFQVN
SAKFLIKDQPLDDKMAAYGALSTYLADLVTRKRAAPGDDILSDLARDDDLTIEELTGAAFLLLLAGHETTANMLALGAFALLENPEQLTELRTDPDLLPDAVEELLRYLSVADIFYRYATEDIELGGETIRAGSTVVVSLLAANRDPQRFDNPDTLDIRRKARGHLSLGHGVHLCLGQQ
LARLEMRAGFEGLLRRFPTLGLAIPAGDVKLRTDMNIYGVHELPVTWTETSR

CYP105AA4 Amycolatopsis azurea GenPept BAD91667 80% to CYP105AA2

1 MTETVPVPQG LPMQRDAGPF APPSEITRLR GARPVSPMVF PDGHEGWLVT GYDEVRQMMA
61 DTRFSSRQDL GILHLPYETP GMPAPTEPSP PMPGMFVAMV PPDHGRLRKR LTGAFTVKRM
121 KQLEEHIVEI TEQHLDAMTK LVPPVDLVKE FALPVPSLVI CELLGVPYED RENFQANSAQ
181 LMVRDQTLEE KMAAFIGMNT FLTELVTRKR ETPGDDILSD LGRYDDLTIE ELAGAAFLLL
241 LAGHETTANM LALGTFALLE HPEQLAELRA DAELLPAAVE ELLRYLSVAD IFFRYATEDL
301 ELGGETIRAG STVIVSLLAA NRDPRRFENP DTLDLHRNAR GLLSFGHGVH QCLGQQLSRI
361 EMRAGFEGLL RRFPTLSLAV PADEVKLKTD MNIYGVHELP VTW

CYP105AA5 Streptomyces lydicus GenPept BAG50414.1 79% to CYP105AA4

1 MSRTVPVPQG LPMERDAGPF DPPRDLTRLR EARPVSPLLF PDGHEGWLVT GYEAVRRLMA
61 DTRFSSRQDI GVLHVPYETP GMPVATEPSP QVPGLFIAMD PPDHTRLRRR LTGAFTVKRM
121 KMLEEHIHDI VERQLDAMAR LAPPVDLVKE FALPVPSLVI CEMLGVPYED RETFQVNSAK
181 FLVKDQPLDE KMAAYGALTT YLAELVTRKR ATPGEDILSD LARQDDLTVE ELTGIAFLLL
241 LAGHETTANM LALGTFALLE HPGQLAELRA HPELLPGAVE ELMRYLSVAD IFYRYATEDI
301 ELGGETIGKG STVVVSLLAA NRDPLRFDNP DALDVRRAAR GHLSFGHGVH QCLGQQLARI
361 EMRAGFDGLL RRFPTLELAL PADEVRLRTD MNIYGVHELP VTW

CYP105AA6 Rhodococcus opacus B4 GenPept BAH51173.1 78% to CYP105AA4

1 MTVKQTHTVS VPHGLPMERD AGPFDPPGDI TRLRDARPVS PLIFPDGHEG WLVTGYDAVR
61 QLLADTRFSS RSDLGIVHVP YETPGMPAAT EPSPQVPGLF IAMDPPDHTR LRRKLTGAFT
121 VRRMKQLEEH IADIVERQLD EMARLTPPVD LVQEFALPVP SLVICELLGV PYADRDTFQV
181 NTAKFLVKDQ ALDEKMAAYG ALTTYLAELV ALKRVTPGED ILSDLARDDD LTIEELIGIA
241 FLLLLAGHET TANMLALGAF ALLEHPEQLA ELRADPELMP NAVEELMRYL AVADIFYRYA
301 TEDIELGGET IGQGSTVVVS LLAANRDPRH FDNPDTLDLH RKARGHLSFG HGVHLCLGQQ
361 LARLEMRAGF AGLLRRFPAL ELAVPAGEVK LKTDMNIYGV HSLPVCLQPV STY

CYP105AA7 Actinosynnema mirum DSM 43827 GenPept EEH76286.1 69% to CYP105AA4

1 MDLTSPIPIP DGLPQERDAG PFAPTTFVAD LRARRPVCPL VFPDGHVGWL VTGHAAVRQV
61 LADTRFSSRL DLGVLHVPHP TPGMPQATEP SPQVPGLFVA MDPPDHTRLR RKLTGAFTVK
121 RMRALEERVA QVVEERLTAM AALTPPVDLV REFALPVPSL VICELLGVPY ADREVFQANT
181 ARFLVKDVEL AEKAAAYGAL TGYLAGLVAS KRAEPGEDVL SDLARHEDLT VEELTGCAFL
241 LLLAGHETTA NMVALGTFAL LEHPDQLAAL RAEPGLLGGA VEELTRYLSV GDLFYRYATE
301 DLELHGELIP AGSTVVLSLL AANHDPEAFE DAGALDVRRD ARGLVAFGHG VHQCLGQQLA
361 RVEMRAGFAG LLRRFPDLAL AVPAGEVPLK TDMNVYGVHA LPVTWGTAAG

CYP105AB1 Saccharopolyspora erythraea NRRL23338

LRSQEPVKRVRTIGGGTAWLVTRHEDVRRVLSDPRMSSDRTMPGFPSLVPGRRAIVAENK
QAMIGMDGQEHAEARRAVIGEFTVRRINRMRPRIQEIVDECVDRMLAAGGPVDLVRELSL
PVPSLVICELLGVPYSDHDFFQSRSALMISRSTPPERRRDVVLELRRYLDELVAEKVREP
ADDLLGRQVAQQSEKGEVDREGLVSLAFLLLIAGHETTANMISLGTLALLDNPDQLARIT
EDPARTPAAVEELLRYFSIVDGATSRTALADIEIGGVLIREGEGVVAVGLSANRDPEAFD
SPDELDLDRQARNHVAFGFGAHQCLGQNLARVELQIVFDTLFRRIPGLRLADGLDGIRFK
DDALVYGAHEMSVTW

CYP105AB2 Salinispora tropica (marine actinomycete)

MTETASIATTRTASGQLTDAEFPVQRGCPFTTPTEYEQIREESSIAKVRLKNGGEAWWIA
GHELGRSVLADRRFSSDRRRDNFPFVSTDPETRAQLQSQPTSMLGMDGAEHAQTRRALMG
EFTVRRMAGLRPRIQQIVDQHIDEMLATPQRSVDLVEALSLPVPSLVICELLGVPYADHD
FFQGLTGPLLRHTTPPEVRLRIQEELNTYLGTLIDRKLTDPTDDLLSRQIAKHRDNGTFD
RASMVSLAFLLLVAGHETTANMISLGVVGLLQHPDQLVIIKDDPDKTPLAVEELLRYFTI
ADSVTARVATEDVQLGDTTINAGDGVVISGLAADRDPTVFAEPDRLDLERGARHHVAFGF
GPHQCIGQTLARMELRIVFDTLFHRIPTLRLAAPLDDIPFKSDAFVYGIEELPVAW

CYP105AB3 Nonomuraea recticatena AB180844 Gene name moxA

64%
to
CYP105AB2
Salinispora
tropica
(marine
actinomycete)
MTKNVADELAGLELPVERGCPFAPPAAYERLRERAPINKVRLTS
GGQAWWVSGHEEARAVLADGRFSSDKRKDGFPLFTLDAATLQQLRSQPPLMLGMDGAE
HSAARRPVIGEFTVKRLAALRPRIQDIVDHFIDDMLATDQRPVDLVQALSLPVPSLVI
CELLGVPYTDHDFFQSRTTMMVSRTSMEDRRRAFAELRAYIDDLITRKESEPGDDLFS
RQIARQRQEGTLDHAGLVSLAFLLLTAGHETTANMISLGVVGLLSHPEQLTVVKANPG
RTPMAVEELLRYFTIADGVTSRLATEDVEIGGVSIKAGEGVIVSMLSANWDPAVFKDP
AVLDVERGARHHLAFGFGPHQCLGQNLARMELQIVFDTLFRRIPSLRLAVPMEDVPFK
GDSVIYGVHELPVTW

CYP105AC1 Saccharopolyspora erythraea NRRL23338

MQKHAPHNADDVLESLPRDRPSGCPFDPPEGLAEIRGQRPLTRLVYGDGHVGWLATGHAV
VRAVLADRRFSSRYELMHFPVAMPGLPAQIPPAQVGDITGIDPPEHTRYRKLLTGKFTVR
RMRALTERVEQITAERLDAMQRLGPPVDLVEAYAQPIPALMICELLGVPYDRLEEFLGLV
AASGDRDLTPEEQFDAFAKIQEFVRELVPAKRAKPTDDLLSDLTTTELTDQELAGIGGLL
LAAGLDTTANILALGTFALLRNPEQIAALREGDADRAVEELLRYLSIAHTGMRSALEDVE
IDGTLIRAGETVTLSIQAANRDPRRFTDPDALDLRRHAAGHLSFGHGIHQCLGQQLARVE
MRVAFPALFNRFPGLRLAVAPEEVPLRGDMNIYGVHGLPVTWDGA

CYP105AD1 Frankia alni ACN14a

MTQAPQYPQTRTCPYEPPPAYKEIGQEGPVVKVSLFDGRESWMVTGYRESREILTHPNLSSLRTHPNFPI
VAPRFRSPVARSLALLAMDPPIHDVYRRYLNPHFSLRSVRAMRPELERIIAGYVDRIIDHGPPADLIEML
AVPMPSLIICHHLGVPYADHDFFQDCSGKVMLAGEEEAGKAAQDLVEYLDNLVTEQQRNPTDGLIGQLVR
ERVSDGDIGHDELVSIALVLLIAAHETTASTLAIGIINLLGHPEELAKLRADISLLPGAIEELLRYVATT
DLVAVRIAKGDIEIAGHHIREGEPVLVSGTLANRDPQVHQRADEFDIQRDDTFHLTFGFGIHQCLGQNLA
RLEIELALRELITRLPGLRLAVPMEELPILSAGTVQRVLELPVEW

CYP105AE1 Frankia alni ACN14a

MNRVTLFDGATAWLVTGHSHSRRLLADPRVSADRSRPDFPVVLPRFEADVFKPLAIIGFDPPQHGLQRGL
LTADFSMRSVRAKRESIERLVESLADRMLAAGPPADLVLDYSLPIPSMVVADLLGVPYADHQFFEDATVR
LLQATTPQGAEAAGEELLNYLDEQIRLRERDPDDTLLSRLGEHVHDEGLGRDIINKIALALLVGGHDTTS
QMIALGVVTLLDHPDQLAILRSDPSALPGVVEELLRMVSVTDLAGVRVATEDVEIDGQVIARGEGLIFCN
SMANRDPAVYDAPYEFDVRRSADDPPATRRHLTFGHGPHQCIGRNLARMELEIAYRVLFEKIPNLRLAVP
RDELPMRHGSTMQGVHRLPVTW

CYP105AF1 Frankia sp. EAN1pec

MSSNQAVVATPPAFPMDRGCPYHPPAGYAQLQQDGPITRATLFDGREVWVVTGYEEARRLLVDPRLSSDR
SRPDFPVLVPRMAAAKLVALVGMDPPEHDIQRRMLIGSFTVRRANALRPDIERIVGGRVDALLAHEPGEV
VDLVPEFALPIPSTVICELLGVPYGDHEFFEEQTRRMVIATSTAAEAAAASRALVDYFDELIARKRERPG
EGLLDELIAERLVTGQIGQDDLASMAMFLLVAGHETTANMLGLSVLALLEHPDQRARLIEDPAGRAAGAT
EELLRFLSVADEIQRIAAADIEVAGVVIRAGDGVYLPTAAANRTAATFPDPDALDIGRVPRGHLAFGYGI
HQCIGQNLARVELEIGLRELFGRIPTLRLAEPVEALGAKPGGSVQGVYRLPVVW

CYP105AF2 Frankia sp. EAN1pec

MTGTEIPEYPLARTCPFHPPAGYARYREHGPVNPVRLYDGRRVWAVTGHAEAREVLLNTRLFSSERADPR
YPATSPRFEAARKVRNFIGMDPPDHTAQRRMLQSSFTMRRINGLRPGIQRLVDELLDAIVAKGPVVDLVP
EFALPIPSIVISELLGVPYGDHAFFEQQSRRVASGTSTLEESADAFTQLLQYLDGLIQDKERSAGDGLLD
VLIAEQVRPGVLTRRELVDISLLLLVAGHETTASAIALGVVALLEHPDQLAALRADPALLPSAVEELLRF
TTIADSVARFATADTELAGQPVAAGDGVLVVLSAANRDGTVFPDPDLLDLARRARSHVAFGHGAHQCIGH
NIARAELEIAFSTLFARLPGLRLAVPLDRLPGKDAGGVQGVFELPVAW

CYP105AG1 Frankia alni ACN14a

MTTRHLIDQPISRDLAHPLDPPAAYTELRENQPVVRARFPNGSTGWLVTRFEEGSQVFSDPRFSAKRRRH
DTPEGEQAEAGDDAPFDAGFVMMDEPDHGVYRRLLTARFTPKAVQTRLQPYLDRIVAEHLDAIAAGPETF
DFVQALSLPIPCLVICELLGVPYADRDGFHHATEVMMDTGVSRAERDRGAHWLVDYITALVADKRRTGDT
EGILAELIGKADDEGSILSERQLVGLGVLLLFAGHDTTAAMMGLSTLTLLTHPEQRRDLTEHPERIGTAV
EELMRYLTIVQFGLGRVAAQDVELGGAHIGRGELVVVAMNAANRDPRVFADPDALDLDRTMVRHLGFGYG
VHACLGQNVARAELRTVLPALFRRFPHLRLATPPNEVPMDFTGTNYGVRKLMVTR

CYP105AH1 Frankia sp. EAN1pec

MRELPPCAVRIPAGAADSRLAWLVTRYPDARQALMDPRLSADETLPGAPVRIQVPPDQKPGSFLRMDDPE
HARLRGTITTEFTARRVRGLRPAVQRLIDELLDGLAAGPRPTDLQDAFSRTLPTLVIARVLGVPDADSPF
FVEKTRVTISQGDTARSYAAYQEMSEYLGVLATRKQKEPADDLMSRLAVNHLATGKITLDELVGIARLVL
VAGHETTTNQIALNILSMLLDDDLRRTVLADDGVRIPQFVEESMRYWSISQDAIVRLAVEDFELGGTTMH
KGDAVVISIPAGNHDESMFPDPDRIDLDRDSGDHLQWGVGPHYCQGAPLARLEMELALKTLFGRFPGLRL
ATDDPDSVFRTGTVFHGVRELPVTW

CYP105AJ1 Frankia sp. CcI3

MQNAHSDLRMSSRGDLLRSPIPLPMAGERTEPAPGMFTAMDPPEHTRYRRHIVEWFSTRRTRSLEPRVIE
IVDQHLDAMIAGGGPADLVSAFAEPVSALVICELLGVPVEQREVFGAAIAALFTVHSSAEEAISGWQNIG
GLLMGLIQAKRVASADDLLGTLVARGELSDEELMTIGSVLLVAGHDTSTNMIAMGTFALLEHPEQYAALA
ADPGLAPGAVEELLRYLTIVHAGSIRAVSADLEFDGHQLTAGDAVSLSLAAANRDPALCDAPDRLDITRE
PVPHLAFGHGIHQCVGQQLSRLELRIAFESLARRLPNLHVAVPTSEIRTRSEMIIYGVRELPVTW

CYP105AK1 SBI_6930 Streptomyces bingchengensis

47% to CYP105S3
MSNLRSNIITWLGRKYFSRIQKNGFDLSKMSFLPSATLAPLRRNGLDPVD
ELSRTRAKEPISKLPLPFGMKGWLVTGYDETKAVLGRTNGFSSDFTNLAE
KNIGIAAQQNPGGLGFSDPPTHTRLRRLLTPEFTMRRLSRLTPRIHSIVE
ERLDEMAAMGAAGDPVDLVQSFALPIPSLVICELLGVPYEDRADFQQLSM
ARFDLFDGADASFGAISDSLSYLLDIVKKQRESPGDGLLGMLVKEHGDEI
DDQELAGLADGVLTGGFETTASMLALGTLVLLRNPEQFAEIRDNDDVVDR
YVEELLRYLTVVQVAFPRFAKEDMEIAGTKISSGDLVLCSLSGANREEKL
GPDMERFDPHRQTPSHLAFGHGIHRCIGAELAKMELRAAYPALVRRFPEM
RLAVPQEKLAFRKLSIVYGVEALPVTLK

CYP105AL1P Frankia alni ACN14a YP_710901.1 CAJ59294.1 42% to CYP105AB1 Saccharopolyspora erythraea MEAPLMTLSVESHLPSCPMERSSPFEPPPGYARARSEAPITKVRLVDGSTGWFVTGHALVRRLLNDPKVS

KNGLRPGYPPLVPDQEALVRGQKGFLVWMDPPDHTMYRRMLAGEFSVNTLERLRPHVEHIVNECIDQLLD
AGPPADLVQVLSLPVPTMTICELLGVPYTDRQLFQESTAATVNLRTTQEERNRTVAELRQCATRAGDRLP
HALPAAPGPARRAADALGADRLRAGRGRTGEDGLVVLLTEDPPEERRQEVIDAAGSCPAQAILVDGE

CYP105 fragment Streptoalloteichus hindustanus

LLIAGHETTANMLALGAFALLEHPEQLAELRANPDLMPGAVEEL
MRYLSIVHIGPVRTAVADVEIEGQLIRAGESVTVSVPAANWDPAKFPEPERLDLTRRT
SGHLAFGHGVHQCLRQNL

CYP106A1 Bacillus megaterium

MNKEVIPVTEIPKFQSRAEEFFPIQWYKEMLNNSPVYFHEETNT
WNVFQYEHVKQVLSNYDFFSSDGQRTTIFVGDNSKKKSTSPITNLTNLDPPDHRKARS
LLAAAFTPRSLKNWEPRIKQIAADLVEAIQKNSTINIVDDLSSPFPSLVIADLFGVPV
KDRYQFKKWVDILFQPYDQERLEEIEQEKQRAGAEYFQYLYPIVIEKRSNLSDDIISD
LIQAEVDGETFTDEEIVHATMLLLGAGVETTSHAIANMFYSFLYDDKSLYSELRNNRE
LAPKAVEEMLRYRFHISRRDRTVKQDNELLGVKLKKGDVVIAWMSACNMDETMFENPF
SVDIHRPTNKKHLTFGNGPHFCLGAPLARLEMKIILEAFLEAFSHIEPFEDFELEPHL
TASATGQSLTYLPMTVYR

CYP106A2 Bacillus megaterium

MKEVIAVKEITRFKTRTEEFSPYAWCKRMLENDPVSYHEGTDTW
NVFKYEDVKRVLSDYKHFSSVRKRTTISVGTDSEEGSVPEKIQITESDPPDHRKRRSL
LAAAFTPRSLQNWEPRIQEIADELIGQMDGGTEIDIVASLASPLPIIVMADLMGVPSK
DRLLFKKWVDTLFLPFDREKQEEVDKLKQVAAKEYYQYLYPIVVQKRLNPADDIISDL
LKSEVDGEMFTDDEVVRTTMLILGAGVETTSHLLANSFYSLLYDDKEVYQELHENLDL
VPQAVEEMLRFRFNLIKLDRTVKEDNDLLGVELKEGDSVVVWMSAANMDEEMFEDPFT
LNIHRPNNKKHLTFGNGPHFCLGAPLARLEAKIALTAFLKKFKHIEAVPSFQLEENLT
DSATGQTLTSLPLKASRM

CYP106B1 Bacillus anthracis str. Ames

1 MASPENVILV HEISKLKTKE ELWNPYEWYQ FMRDNHPVHY DDEQDVWNVF LYDDVNRVLS
61 DYSLFSSRRE RRQFAIPPLE TRININSTDP PEHRNVRSIV SKAFTPRSLE QWKPRIQSIA
121 NELVKDIENC SEVDIVEQFA APLPVTVISD LLGVPTTDRK KIKAWSDILF MPYSKEKFND
181 LDAEKGIALN EFKAYLLPIV QEKRYHLTDD IISDLIRAEY EGERLTDEEI VTFSLGLLAA
241 GNETTTNLII NSFYCFLVDS PATYKEVREK PKLISKAVEE VLRYRFPVTL ARRITEDTNI
301 FGPLMKKDQM VVAWVSAANL DEKKFSQASK FNIHRIGNEK HLTFGKGPHF CLGAPLARLE
361 AEIALTTFIN AFEKIALSPS FNIEQCILEN EQTLKFLPIR LKPQ

CYP106B2P Bacillus cereus ATCC 14579

1 MTSVITDGEI VTFSLGLLAA GNETTTNLII NSFYCFLVDS PGIYEELRKE PNLILKAIEE
61 VLRYRFPVTL TRRITALSER ESPSPLGMG

CYP106B3P Bacillus cereus ATCC 14579

LKEDTNIFGPF
1 MKKNQMIVAW VSAANLDEKK FSQASQFNVH RTGNEKHLTF GKGPHFCLGA PLARLEAEIA
61 LTTFINAFEK IELFPSFCLE KCILENEQTL KYLPIRLKAT

CYP107A1 Saccharopolyspora erythraea

MTTVPDLESDSFHVDWYRTYAELRETAPVTPVRFLGQDAWLVTG
YDEAKAALSDLRLSSDPKKKYPGVEVEFPAYLGFPEDVRNYFATNMGTSDPPTHTRLR
KLVSQEFTVRRVEAMRPRVEQITAELLDEVGDSGVVDIVDRFAHPLPIKVICELLGVD
EKYRGEFGRWSSEILVMDPERAEQRGQAAREVVNFILDLVERRRTEPGDDLLSALIRV
QDDDDGRLSADELTSIALVLLLAGFEASVSLIGIGTYLLLTHPDQDQLALVRRDPSAL
PNAVEEILRYIAPPETTTRFAAEEVEIRGVAIPQYSTVLVANGAANRDPKQFPDPHRF
DVTRDTRGHLSFGQGIHFCMGRPLAKLEGEVALRALFGRFPALSLGIDADDVVWRRSL
LLRGIDHLPVRLDG

CYP107A2 Streptomyces rochei plasmid pSLA2-L

MTTDAHTAVPSLDSDLFHIDQYEAYAALREREPVSKVSFIGREA
FLITRHAEAKAALGDLRLSNDFKKQPPGVELPTYHGIPEDVRPYFANNMGSNDPPAHT
RLRRLVSREFTARRVESMRTRVAQLAEHLLDGLAGERETDLVERFAYPLPITVISELL
GVEERYQGDFGRWSNEFLVIDADRVEQREHAARALVGFILELVDRRRADPGSDLLSAL
IHVHDEDEDRLSTDELASVVLILLIAGFETSVSLIAMATYLLLTHPGELAKVRADPSL
VPNAVDEVLRFLGPAEITTRGTLEPVEIGGVHIPAHSTVLIAGAAANRDPRRFPDPER
FDVTRDTGGHLSFGHGIHFCVGGPLARLEGEIALRALLNRFPGLDLAIPAEQVRWRRS
FLRGIESLPVRLGR

CYP107B1 Saccharopolyspora erythraea NRRL23338

MTTGEVPDLLAFDDAFAQDRHNRYARMREEPVQRIRTVNGLDAWLITRYEDVKQALLDPR
IAKDFGRTQQIIEKRLADAERRPGFSPDLGPHMLNTDPPDHTRLRKLVVKAFTARRVEGL
RPRIEQITDDLLDRLAGRSEVDLIDEFAFPLPITVISELMGVEDSRRDDFRSWTNVLVDG
SQPEAQAQASVAMVEYLTELIAKKRTEPGDDLLTALLEAVEDGDRLSEGELIAMVFLLLV
AGHETTVNLIGNCVLSLLGNPDQLAALRNDPSLLPGAIEETLRYESPVANGTFRHTAEAV
RFGDVVIPEGELVWVALGAANRDGERFEDPDRFDITRETTGHVAFGHGIHFCVGAALARL
EAQIAVGRLLERFPDLRMAASPDDLRWRFSVLMRGLEKLPVRPGA

CYP107B2 Streptomyces sp.

LIAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDSPVGIATFRFSTE 182
183 ALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFGFGMHHC 344

CYP107C1 Streptomyces thermotolerans

MTALNLMDPEVLRDPFGAYAEIRAQAPLVRASYPWGAVQWLATR
YSDVKAVLTDPRLVNNPANVPEMHLPHPYEQALGDGGIPDEYVRYLAGSILSQDGPGH
LRLRRLSSRAFTVRRVNALRPRVTELAHRLLASLPDRAQDGVIDVLEDFSYPLSIDVI
CEIVGIPEEAREQWHTWGSAFYTMDPAVIGPAVRGMADHLHLLIEQRRATPTGDLLTG
LVQAEDEQGEPLTDEEIATLVLTFVTAGNETTAHLIGNGVAALLTHSDQLALLRSDRR
LLSQAVDELMRWCTPVQVTQPRYATEDLDVGGVTVRKGEQVVAVIGAAGHDPDRFPDP
ERFDITRNHRAPHEAHVGFGFGPHYCLGAALAHQETAIALDTLFDRFPSLALAVPPSA
LERQPFPGAWRLKSLPVRL

CYP107D1 Streptomyces antibioticus

MTDTHTGPTPADAVPAYPFSLPHALDLDPHYAELRRDEPVSRVR
LPYGEGTAWLVTRMSDARIVLGDSRFSTAAATDPATPRMFPTPPEPDGVLAQDPPDHT
RLRRLVGKAFTARRVEEMRPRVRSLVDSLLDDMVAHGSPADLVEFLAVPFPVAVICEL
LGVPLEDRDLFRTFSDAMLSSTRLTAAEIQRVQQDFMVYMDGLVAQRRDAPTEDLLGA
LALATDNDDHLTKGEIVNMGVSLLIAGHETSVNQITNLVHLLLTERKRYESLVADPAL
VPAAVEEMLRYTPLVSAGSFVRVATEDVELSTVTVRAGEPCVVHFASANRDEEVFDHA
DELDFHRERNPHIAFGHGAHHCIGAQLGRLELQEALSALVRRFPTLDLAEPVAGLKWK
QGMLIRGLERQIVSW

CYP107E1 Micromosospora griseorubida

MTSAEPRAYPFNDVHGLTLAGRYGELQETEPVSRVRPPYGEEAW
LVTRYEDVRAVLGDGRFVRGPSMTRDEPRTRPEMVKGGLLSMDPPEHSRLRRLVVKAF
TARRAESLRPRAREIAHELVDQMAATGQPADLVAMFARQLPVRVICELLGVPSADHDR
FTRWSGAFLSTAEVTAEEMQEAAEQAYAYMGDLIDRRRKEPTDDLVSALVQARDQQDS
LSEQELLDLAIGLLVAGYESTTTQIADFVYLLMTRPELRRQLLDRPELIPSAVEELTR
WVPLGVGTAFPRYAVEDVTLRGVTIRAGEPVLASTGAANRDQAQFPDADRIDVDRTPN
QHLGFGHGVHHCLGAPLARVELQVALEVLLQRLPGIRLGIPETQLRWSEGMLLRGPLE
LPVVW

CYP107E2 Saccharopolyspora erythraea NRRL23338

MPEPRPYPFSAAERLNLDPFYARLRAQEPMSRVKLPYGEAAWLATRYEDAKVVLADPRFS
RAAVLEKDEPRMRPGITGGGILSMDPPDHTRLRRLVAKAFTQRRVERLRPRTQEIADGLV
DRMIEHGSPADLVEEFALPLPITVICELLGVPYEDRDDFREWSDAFLSTTKLTPEQVVDY
MDRMFGYMAGLIAKRRVDPQDDLMSALIEARDEHDKLTEQEMVQLAAGILVAGHETTATQ
IPNFVYVLLTHPDQLEGLLADLDGLPRAVEELTRYVPLGVAAVFARYAVEDVELGGVTVR
AGEPVLVSASSANRDEAVFDDPDRLDLTRENNAHIGFGHGPHHCLGAQLARLELQVGLRT
LLTRLPGLRFAGGEDDVVWKEGMLVRGPSKLEVAWQSE

CYP107E3 Salinispora tropica (marine actinomycete)

MTIDQEIRKYPFCESPGIGIDPTYGLLRSTEPLARVQLPYGEVSWLATRYEDVKTVLTDP
RFSRAAAQGKDQPRTREEMTYEGIIGLDPPDHTRLRKLAGKALTARRVNAIRADAQRIAN
EYVDEMIAKGSPGDLVELFALPYPVTVICELLGVPFEDRAQFRIWTEGLTSTSEQLMVYA
EQLFGYMGKLVAQRREEPTDDLLGALVKARDEGDRLTEQELLSIAGVGLLLTGVETVSTH
IPNFVYALLTHPELMAQLRADRSLVPAAVEELLRMIPLNPAAMFPRYAVEDVTLSGITVR
AGEPVLVSLPGANRDPEVFENPETFDFTREQNPHVAFGHGPHHCLGAQLARMELQVALHT
VLDRFPDLSLADGDEGVSWKSGLLVRGPSRLLVAW

CYP107E4 Actinoplanes sp. ATCC 53771

MTTTDTEFVAYPFNEDAGLELNEAYAAARATEGMLRVRLPHGEP
AWLATRYADARFVLGDRRFSRAMAVERDEPRMAPGRRPGGILSMDPPDHTRLRTLVAK
AFTMRRVELLRPRVAELASGLIQDMKAKGQPADLVEDYALPIPVAVICELLGVPVEDR
PKFRVWSDAALSTSPLTTEEMMANQDELRAYMHVLVEQHRAEPQDDLMTALIEARDVR
DRLSELELVDMCIGILIAGHETTASQIPNFVYALLEQPDQLARLRADLDLIPAAVEEL
LRFIPLGAGAGFARYATEDIQVGDVLVKEGEPVMVAIGAANRDALQFTSADTLEFGRE
SNPHLGFGHGVHHCLGAPLARLELQEALRALLRDLPGLHLDGDIVWKTQMLVRGPRSM
PIGW

CYP107E5 SBI_8067 Streptomyces bingchengensis

57% to CYP107E2 Saccharopolyspora erythraea NRRL23338
VTTAETTVQSEAIAYPFNSSEGLGLSQAYQEARNRPGLVRVRMAYGEPAW
LVTRYAEARLVLGDRRFSRAAALHRDEPRQGEGRRNSGILTMDPPEHTRL
RTLVAKAFTVHQVEKLRPSVRQLTHELLDGLEAAGPPADLVDRYALPIPV
GVICRLLGVPEEDRPKFRAWSDAALSTSSLSAEEFDRNRDELRAYMAGLI
EIHRAAPQDDLMTSLIEARDAGDRLSELELVDLCVGILVAGHETTATQIP
NFVLTLLDHPGELRRLREEPALLNGAVEELLRFVPLGKGASQPRYATEDI
EVGGQLVRAGEPVLVAVGSANRDALRFDEPGKLNVARPATQHLGFGHGVH
HCLGAPLARLELQEALGALITRFPGLCLTGDVVWKDQMLVRGPRVMPVGW

CYP107F1 Streptomyces griseus D45916

MENTSVQNKETVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMA
YGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSR
LRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPGDFVARVSAPLPLITICEAL
DIPEADRPWLRAHAMTMMNVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTL
ATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRL
PRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPD
ELDPDRPTIPHMTFGWGAHHCLGAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNT
TSIWRYPLALPVTW

CYP107F1 SGR6619 Streptomyces griseus 1 aa diff to D45916

MENTSVQNKETVRNCPFDYAHELEFDPQLRQLLTEEPVSRIRMAYGEGEAWLVTRYEDVRTVTTDRRFSRSAVLGRDFPRMTPEPIVQAESINLMDPPASSRLRGLVAKSFTPRRVEQMRGGTQRVVDRLLDEMEEEGSPADFVARVSAPLPLITICEALDIPEADRPWLRAHAMTMM
NVGAAGKQDAVRAKAELRGYFQELTADRRRSPGEDLISTLATARDGDELLDDDELAVMAMVLLITGQDTTTYQLGNIAYTLLTRPDLLRSLRAEPQRLPRTLEELLRHIPFRKGVGIPRIALEDVELSGVLIKAGDVVHVSYLTANRDSAKFDRPDELDPDRPTIPHMTFGWGAHHCL
GAPLATMELEVAFSTLLTRFPALRLDVPPEDVSWNTTSIWRYPLALPVTW

CYP107F2 Streptomyces avermitilis

MTPSDEAIMCPFDFSKGLEFDPSLAELMARDSITRIRLPYGDAD
AWLVTGFDAVRQVTTDQRFSRAGIMGSDYPRLTPEPIVSPESINVVDPPHSSRLRRLV
SQAFTKGHVERMRRRIVRLADTLLDEMAAQGPPADLAHHLSNRLPQHTICDVLGIEQD
DWPRMEQYVHQLLSTGPDSRQSAATAKSELREYFGGLVEKRRSSPGNDLISALAAAKD
GEDVLDDQELAVMALTLMLSGHDTATCQISNICYLLLTRPELMKHLRSRPDTLTAVLN
EMLRFIPFRKGVGIPRVAVEDAEVDGVKIRAGDFVHVSYLTANRDPERYPDPDAIDPD
RPSLPHMTFGWGGHRCIAVPLAMAELEVAIGRLLERFPELRLAVPPEEVRWDTETIRR
FPIELPVAW

CYP107G1 Streptomyces hygroscopicus

MSTTDQGETGKACPYPFAEMERLEIHPEYNRLRDAGELGRVLML
DGREAWLAASWEDVAKVFVDPRFSRSATLGKDVPRVLPAIQDQPVIMLMDPPEHTRLR
RVATKALTSRRMEALRPRTQEVADDLIDKMLAKGAPADLMEDFALPLPIIMICELLGV
PIEDQTKFRTWSDQMLSNGAYSQEVVMAAGQSLYLYLSELIAERRKQDTNDLLGSLVR
ARDKDDRLSETELVGFAVTLLIAGYETTANAIGNSVYTLLTHPEKLAELRKDLSLIPK
AVDELLRIIPIAKQASWVRMAVEDVELSGTIVKAGEAVAIQTHSANTDPKVYDHPEEI
DFHRTSNPHMSLGHGAHHCMGAQLVRVEMQTALGSLISRIPALRFAVPEPRIKFLRGR
LVPSLEALPLTW

CYP107H1 Bacillus subtilis

MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG
YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP
RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE
WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD
KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL
RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP
HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV
TFE

CYP107J1 Bacillus subtilis

MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL
GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP
DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS
EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD
LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ
QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF
PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM
KWKGNFLMRALEELPISF

CYP107J2 Bacillus anthracis str. Ames

1 MAMKNKVGIR IEDGINLASA QFKEDAYEIY KESRKVQPVL FVNKTELGAE WLITRYEDAL
61 PLLKDNRLKK DPANVFSQDT LNVFLTVDNS DYLTTHMLNS DPPNHNRLRS LVQKVFTPKM
121 IAQLEGRIQD IADDLLNEVE RKGSLNLVDD YSFPLPIIVI SEMLGIPKED QAKFRIWSHA
181 VIAYPETPEE IKETEKQLSE FITYLQYLVD MKRKEPKEDL VSALILAESE GHKLSARELY
241 SMIMLLIVAG HETTVNLITN TVLALLENPN QLQLLKENPK LIDAAIEEGL RYYSPVEVTT
301 SRWADEPFQI HDQTIEKGDM VVIALAAANR DETVFENPEV FDITRENNRH IAFGHGSHFC
361 LGAPLARLEA KIAITTLFER MPELQIKGNR EDIKWQGNYL MRSLEELPLT F

CYP107J3 Bacillus cereus ATCC 14579

1 MKNKVGLSIE DGINLASAQF KEDAYEIYKE SRKKQPILFV NQVEIGKEWL ITRYEDALPL
61 LKDNRLKKDW TNVFSQDIKN MYLSVDNSDH LTTHMLNSDP PNHSRLRSLV QKAFTPKMIA
121 QLDGRIQRIA DDLISDIERK GTLNLVDDYS FPLPIIVISE MLGIPKEDQA KFRIWSHAVI
181 ASPETPEEIK ETEKQLSEFI TYLQYLVDIK RKEPKEDLVS ALILAESEGH KLSARELYSM
241 IMLLIVAGHE TTVNLITNTV LALLENPNQL QLLKDNPKLI DSAIEEGLRY YSPVEVTTAR
301 WAAEPFQIHH QTIQKGDMVI IALASANRDE TVFENPEIFD ITRENNRHIA FGHGSHFCLG
361 APLARLEAKI AITTLFNRMP ELQIKGNREE IKWQGNYLMR SLEELPLTF

CYP107J4P Bacillus cereus ATCC 14579

1 MKEPQLQQHL EKFIQYIEAL VNEKRLNPDA DLISELVQTK EQEDKLSNNE LLSTIWLLII
61 AGHETTVNLI SNGLLALLQH PEQMNLIREN PSLIPSAVDE LLRHSGPVMF ISRLASEDMT
121 IHGKRIPKGD LVLLSLTAAN IDPQKFTYPE TLNISREENN HLAFGAGIHH CLGAPLARLE
181 GQIALGTLLQ RLPNLRLAIK PDQLNYNHSK IRSLVNLPVV F

CYP107K1 Bacillus subtilis

MQMEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATY
PAWLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHT
RLRSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELM
GIPKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKL
VHAEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMI
ATAVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEI
LNINRSPNRHISFGFGIHFCLGAPLARLEGHIAFKAAFEEIS

CYP107L1 Streptomyces venezuelae

MRRTQQGTTASPPVLDLGALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDRARAVLADPRFSKDWRNSTTPLTEAEAALNHNMLESDPPRHTR
LRKLVAREFTMRRVELLRPRVQEIVDGLVDAMLAAPDGRADLMESLAWPLPITVISEL
LGVPEPDRAAFRVWTDAFVFPDDPAQAQTAMAEMSGYLSRLIDSKRGQDGEDLLSALV
RTSDEDGSRLTSEELLGMAHILLVAGHETTVNLIANGMYALLSHPDQLAALRADMTLL
DGAVEEMLRYEGPVESATYRFPVEPVDLDGTVIPAGDTVLVVLADAHRTPERFPDPHR
FDIRRDTAGHLAFGHGIHFCIGAPLARLEARIAVRALLERCPDLALDVSPGELVWYPN
PMIRGLKALPIRWRRGREAGRRTG

CYP107L2 Streptomyces avermitilis

MGNVIDLGEYGARFTEDPYPVYAELRERGPVHWVRTPPPEAFEG
WLVVGHEEARAALADPRLSKDGTKKGLTSLDVELMGPYLLVVDPPEHTRLRSLVARAF
TMRRVEALRPRIQEITDGLLDEMLPRGRADLVDSFAYPLPITVICELLGVPDIDRVTF
RALSNEIVAPTGGDAELAAYERLAAYLDELIDDKRSTAPADDLLGDLIRTRAEDDDRL
SGEELRAMAFILLVAGHETTVNLITNGVHTLLTHPDQLAALRADMTLLDGAVEEVLRF
EGPVETATYRYAAESMEIGGTAIAEGDPVMIGLDAAGRDPARHPDPHVFDIHRAPQGH
LAFGHGIHYCLGAPLARLEARVALRSLLERCPDLALDGPPGARPPGMLIRGVRRLPVRW

CYP107L3 Streptomyces tubercidicus strain I-1529

VSEDRIVDLAALGEEFTRDPHPVYAELRARGPVHRVRLPEGFEAWLVVGYEAARAALSDPRLSNDWRRAAGADEGD
PAAAPHMLISDPPRHTRLRRLVVKEFTPRRIEALGPRVREITDELIDAMLSRPGGRADLVEDFAFPLPAAVICELL
GVPYADRKTFHEWSTEVTKRSGGPRAEAAMGELAGYLMRLLEEKGRRPGDDLLSALIRTTGEDGDRLSSDELLGMA
VLLLIAGHETTAGLISNGMLALLRHPDQLAALQADFGLLDGAVEEMLRHSGPTGTSLHRFTTGPVDIAGTRIPGGG
ELVLIGNTPANHDPGRYPDPGRFDIRRDHRGHLAFGHGIHYCFGAPLARLEARTAIRTLLQRCPGLALDAAPDELV
WHHSAMMRGLPHVPVRTVPAPAAPAPQVHQVSSAH

CYP107L4 Streptomyces tubercidicus strain R-922

VSEDRIVDLAALGEDFTRDPHPVYAELRDRGPVHRVRLPEGFEAWLVVGYEAARAALADPRLSNDWRHAAGAGAGD
PAAAPHMLISDPPRHTRLRRLVVKEFTPRRIEALGPRVREITDELIDAMLSRPDGRADLVEDFAFPLPAAVICELL
GVPYADRKAFHGWSTEVTKRSGGPQAEAAMGELAGYLVRLLEDKGRRPGDDLLSALLRTTGEDGDRLSSDELLGMA
VLLLIAGHETTAGLLSNGMLALLRHPDQLAALHADFDLLDGAVEEMLRHSGPTGTSLHRFTTAPVDLAGTLIPGGG
ELVLIGNTPANHDPGRFPDPGRFDIRRAPHGHLAFGHGIHYCFGAPLARLEARTAIRALLERCPGLALDADADRLV
WHHSAMMRGLPHVPVRVRPAPGTPAAQVHHASSAR

CYP107L5 Streptomyces sp.

LIAGHETTVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAE 182
183 PLEIGGTVIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGFGTHRC 344

CYP107L6 Streptomyces sp.

MGHEHVIDLGEYGPGFTENPHPVYAELRARGPVHRVRLPKHDAHHEAWLVVGYEEARAAL
ADPRLSKDGSTIGVTFLDEELIGKYLLIADPPQHTRLRGLIAREFTGRRVERLRPRVQEI
TDSLLDEMLPRGRADLVESFAYPLPLTVICELLGVPEIDRAAFRKLSTEAVAPTSGESEY
AAFVQLAAYLEELVEEKRCAPPADDLLSALIRTTDEDGDRLSPAELRGMAFILLIAGHET
TVNLITGAVHALLTHPGQLAQVRGDMSLVDAVVEETLRHEGPVENATFRFAAEPLEIGGT
VIPAGDPVLIGLAAADRDGARYPGPDRFDIHRDTRGHLAFGHGIHFCLGAPLARLEARVA
LRALLERCPGLTPDGAPGEWLPGMLIRGVRSLPVRW*

CYP107L7P Streptomyces narbonensis

MSRTHQGTTASRPVLDLAALGQDFAADPYPTYARLRAEGPAHRV
RTPEGDEVWLVVGYDTARAVLADPRFSKDWRNSATPPTEAEAALSHNMLESDPRCGPT
(deletion)
ALRADLTLLDGAVEEMLRYGGPVESATYRFPVEPVDLDGTVLPAGETVLVVLAD
AHRTPERFPDPHRFDIRRDTAGHLAFGHGIHFCTGAPLARMEARIAVRALLERCPDLALD
VSPGELFWYPNPMIRGLESLPIRWRSGREAGRRVPVEPACRP*

CYP107L8 Streptomyces sp. HK803

MVTVDLSAYGPGFFTDPYPYYARLREAGPVHEIVLADGDRFWLI
VGYDEARAALADPRLAKSLDPPSEDERHVLITDPPDHTRLRRLVSREFTARRVEAMRP
RVQEITDGLLDEMVAGRRRADLVPSLGSPLPITVLCELLGVPLADREDFRGWTERVLV
PAEPDTIAWWKSRGFAQAGMALTDYLKNMIEDKRRSTPTGDLISSLLRTTAEDNDRLS
AAELHSMVFILIVAGHETTANLITNGVRALLAHPEQLAALRTDPEGLIDQAVEEMLRY
DGPVETSTKRFTLEAVRYGATKIPPGETLLVSIAATGRDPAQFERPDTFDIHRGTTGT
RSGHVAFGHGIHFCLGAGLARMESRVAILTLLRRCPDLALDIDPAGLDWLPGIRVRGV
RSLPVRW

CYP107L9 Streptomyces peucetius

MTIVDLADYGPDFTANPYPYYERLRASAPAHRVRGADGGEFWLIVGHEEARAALGDARLS
KSPATMGTTMLDEQVIGPNLLVVDPPDHTRLRKLVVREFTPRRAEALRPRVQRITDDLLD
AMVPAGRADLVDALAFPLPIVVICELLGIPAADRDAFRTWSNEVVAPTSPETGEDAVRQL
GAYLDGLIADKRCAGPTDDLLSALIRTKDEDGDRLSFTELRALAYLLLIAGHETTVNLIS
NGVRALLAHPDQLAALRADFSLLDGAVEEMLRYDGPVETATVRFSAAPVPVGDLVIPPGE
VVL SAWRPPTATPPATPDPTASTSAGTPAAISPSGTASTSASALRWPAWRPGSPSAPSWS
AAPPSPWTKRRTRTNGSRAS*

CYP107L10 SGR1278 Streptomyces griseus

MTTEPLVDLAALGEQFTRDPYPAYAALRAKGPVHRVRIPEGAEAWLVVGYEQGRALLADQRLSKHWSRASPSLGVSKVSAGSSMLGSDAPDHTRMRKLVAREFTPRRMEQLAPRVQEMTDGLLDAMLAAPDRTADLVEALSFPLPMAVICELLGVPSLDREAFRTWSGQAVSSVD
PSLRASSTQAMTAYIAGLLADKRERPGEDLLSALIHTSDEDGDRLSGDELIGMAWLLLVAGHETTVNLITNGVHNLLAHPDQLAALRADFTLIDNAVEEILRFEGPVETPTYRFTTDPIEVGGTVIPGGGELVLVAMSDANRDPARYPDGSRFDITRDARGHIAFGHGIHYCLGAPLARIE
ARIAIRSLLERCPELRSAADPATLPWRTGILMRGPLSLPVGW

CYP107L11 SGR1279 Streptomyces griseus

MAVLDLRDLPDFTTNPYPYYAKLRAEGPVHAVRTEEMEQRVWLVVGHAEARAALADQRLGKDWRHTGLWTESEAALSANMLELDAPHHTRLRRLVSREFTARRIEALRPRVTEITGELLDAMAPRGSADLVDALAFPLPMTVICELLGVPDIDRDAFRALSNGIVTPTPEQRGADP
AGAMGAYLDGLIENKRRSPGDDLLSGLIRTGEADGEGLSSAELVGMAFLLLVAGHETTVNLIANGVRALLDHPDQLALLRADPGLLDNAVEEMLRYDGPVETATFRFARETLTIGDTEIHVDEPVLVALASADRDPLRFRDPDTFDIRREPQGHLGFGHGVHYCLGAPLARMEARIAI
GALLERFPGLARDPSGGELDWLPGLLMRGARGLPVRW

CYP107M1 Actinomadura hibisca

MPSSKDAPTVDPRPDVTPAFPFRPDDPFQPPCEHARLRASDPVA
KVVLPTGDHAWVVTRYADVRFVTSDRRFSKEAVTRPGAPRLIPMQRGSKSLVIMDPPE
HTRMRKIVSRAFTARRVEGMRAHVRDLTSGFVDEMVEHGPPADLIAHLALPLPVTVIC
EMLGVPPEDRPRFQDWTDRMLTIGAPALAQADEIKAAVGRLRGYLAELIDAKTAAPAD
DLLSLLSRAHADDGLSEEELLTFGMTLLAAGYHTTTAAITHSVYHLLREPSRYARLRE
DPSGIPAAVEELLRYGQIGGGAGAIRIAVEDVEVGGTLVRAGEAVIPLFNAANRDPEV
FADPEELDLGRTDNPHIALGHGIHYCLGAPLARLELQVVLETLVERTPALRLAIDDAD
ITWRPGLAFARPDALPIAW

CYP107N1 Streptomyces lavendulae

MTGPEAAVRGCPFGAGEAPAYPFHAPDRLEPDPYWEPLRRERPL
QRVTLPYGGEAWLATRYQDVRAVFADRRFSRQLAVAPGAPRFLPHQPPPDAVLSVEGP
DHARLRRLVGKVFTPRRVEDMRPLIQRTADGLLDAMEEMGPPADLVEDFSLPFAVSMI
CELLGVPPEDRKRFCVWSDALLTTTAHTPAQVRDYMMQMHDYLGGLVAQRRVRPTADL
IGSLVTARDEEDKLTEGELVRLAEAILIAGYETSASQIPNFLYVLFRHPQLLERIRND
HDLIPDAVEELLRFVPIGTVDGFPRTATEDVELGGVLVRAGETVVPSMGAANRDPELF
TDPDELDLARRPNPHLGFGAGPHHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESL
SWKEGLMVRGMHTMPVTW

CYP107N3 Streptomyces peucetius

VTGRATDPATEGSRCPFAAGEAPAYPFGSPDRLEPDPYWEPLRREQPLQRVTLPYGGEAW
LATRYQDVRKVFADRRFSRALAVAPGAPRFLPHQPPADAVLSVEGPDHARLRRLVGKVFT
PRRVEAMRPLIQSTADRLLDAMEEIGPPADLVEDFSLPFAVSMICELLGVPPEDRKRFCT
WSDALLTTTAHTPAQVRDHMMQMHDYLGGLVAQRRTRPTEDLIGSLVTARDAEDKLTEGE
LVRLAEAILIAGYETSASQIPNFLYVLFRNPHLLERLRNDHDLIPDAVEELLRYVPIGTV
DGFPRTATEDVELGGVLIRAGETVVPSMGAANRDPELFADPEELDLTRSPNPHLGFGAGP
HHCLGAQLARVELQITLTTLFRRYPRLRLAVPEESLAWKAGLMVRGMHTMPITW*

CYP107P1 Streptomyces coelicolor cosmid H10

MTAATDGPHVSGPAFDPWDPAFVADPYPAFAELRARGRVLYYEP
SDQWLVPHHADVSALLRDRRLGRTYQHRFTHEDFGRTPPPPEQEPFHTLNDHGMLDLE
PPDHTRIRRLVSKAFTPRTVERLKPYVHGLADDLVARLVAAGGGDLLTDVAEPLPVAV
IAEMLGIPESDRAPLRPWSAEICGMYELNPSEETAAKAVRASLDFSDYLRALIAARRK
EPGDDLISGLIAAHDEDDRLTEQEMISTCVLLLNAGHEATVNATTNGWLALFRHPDQL
AALRADHSLVPSAVEELMRYDTPLQLFERWVLDEIEIDGTTLPRGAEVAMLFGSANHD
PAVFTDPERLDLTRRDNPHISFSAGIHYCIGAPLARIELAASMTSLLKRAPGLRLAAE
PERRPNFVMRGLTELRVEL

CYP107P2 Streptomyces avermitilis

MAAAFDLAFDPWDPAFLADPYPAYADLRAKGRVHYYEPTNQWLV
PHHADVSALLRDRRLGRAYQHRYTHEDFGRTAPPAEHEPFHTLNDHGMLDLEPPDHTR
IRRLVSKAFTPRTVEQLKPYVAKLAGELVDRLVAAGGGDLLADVAEPLPVAVIAEMLG
IPESDRAPLRPWSADICGMYELNPPKDVAAKAVRASVEFSDYLRELIAERRKEPGDDL
ISGLIAAHDEGDRLTEQEMISTCVLLLNAGHEATVNATVNGWYALFRNPDQLAALRAD
HSLVPAAVEELMRYDTPLQLFERWVLDEIEIDGTTVPRGAEIAMLFGSANHDPEVFRN
PEKLDLTREDNPHISFSAGIHYCIGAPLARIELAASMTALLEKAPTLGLVAEPKRKPN
FVIRGLEGLSVAV

CYP107P3 Streptomyces peucetius

MLGIPVPDRPLLRPWSADICGMYELNPSQETAARAVQASVEFSAYLRELIAARRAEPGED
LVSALIAAYDEGDRLSEQEMISTCVLLLNAGHEATVNTTVNGWWTLFRYPEQLAALRADH
SLLSTAVEELMRYDTPLQLFERWVLDDIEIDGTLVPRGCELALLFGSANRDGARFDHPDE
LDLARQDNPHVSFGAGIHYCLGAPLARIELAAT
FGERCGSARRCGSRRSHGGRGAL*

CYP107P4 SBI_9576 Streptomyces bingchengensis

75% to CYP107P1 Streptomyces coelicolor
MSSSAAPAPVFDPWQPSFVADPYPAYAALRERGRAHYFEASRQWLIPRHE
DVRVLLRDRRLGRTYLHRFSHEEFGRTAPPPEHEPFHTLNGHGMLDLEPP
DHTRLRRLVSKAFTPRTVERLAPVVERLADELVEAFVAEGGGDLVAAVAE
PLPVAVIAEMLGIPPADRAQLRPWSADICGMFELNPGDEAARRAVRASVE
FSEYLRELIAARRRNPGEDLISGLVAAYDEGDRLTEQEMISTCVLLLNAG
HEATVNSTGNGWLALFRHPDQLALLRSDPDALLPTAVDELLRYDTPLQLF
ERWVLDDIEVGGTVIPRGSEVALLFGSANRDPERFPDPDRLDLSRTDNAH
FSFGGGIHYCLGAPLARLELAASFGALLRRAPGLRPAAEPRWNPGFVIRG
LQELLVEV

CYP107P7 SGR3408 Streptomyces griseus

MHVSFDPWSPAFVADPYPAYTALRAAGRAHWFEPTGQWLIPHHSDVSALLRDRRLGRTYLHRFSHEEFGRTPPPAAHEPFTTLNGQGILDLEAPDHPRIRRLISRAFTPRTVENLAPTVRRLAAELVDAFVAKGGGDLLAEVAEPLPVAVIAEMLGVPEADRGLLRPWSAAICGMFEL
NPSEETAEAAVRASVDFSAYLRGLIAERRADPGEDLVSALIAAHDEGERLTEQEMISTCVLLLNAGHEATVNTTVNGWRTLFHHPEQLAALRADPALLPSAVEELLRYDTPLQMFERWVLDDIELDGQVIERGAEVALLFGSANRDPERFARPDTLDLSRQDNPHLTFGAGIHFCLGAP
LARLELAASFGELLRKAPALRMTAEPEWHPGYVIRGLKELRAEV

CYP107Q1 Amycolatopsis mediterranei

PVPLSIVSRDRVSIQRLACKVFGETRSGPPGRASFVLIAPRRPQ
TVHKGHNSEHCQVGGCSTGRPLPTVRNRACRTRAGRPRRHQEGMAMTATAKPSAKPVD
LFSPEVVADPFGWYARLREEPLPHTGTLNLGTMMGGPDMWLATRYEDVLTVLTDPRFL
TNPPADSPLADIRDGVFKAMNFPEDLIPWMANKLNTADGEDHTRLRKLVSYALTARRV
NALRPRVEKITEDLFDRMAEQGKDGSPVDIVEEFCFPLPVTVICELVGIDEPDRAAWH
AWGNAMATMDGPKIPPALRECIALSRELMARRRVEPKDDLVTALVQAQADDPGRVSDD
EIVGILFSLVTAGHQTTTYLIGNSVLFLLEQPEQLARLKAEPALWAQAVRELQRLGPL
QFTQARFPSEDVELGGVTIPRGTPVAPLLLAANTDPRKFPEPDKLVVDRLSVANEMHL
SFGKGIHRCLGQHLAYQEAEVALHGLFTRFPDLALAVPRDEIPWILRPAFTRTKTLPL
KLA

CYP107Q2 Amycolatopsis mediterranei

MTTTAETSAEPVDLFSPEVVADPWGAHAAVREAPTLQIGGFMGG
PPMYLAARYEDVRQVLMDQRFQCNPLADSPAEDIRNGVFRHLDMPEELIPWLKNLINA
SDGEEHARLRKLVSYALTAHRVGKFRPRVEELTAELLDKLEAAGGDGTPIDLVESFCY
PLPVTVICELVGVDHEDRPQWRAWSDAMATLDGKRLPEEVRKTLAAARGMIERRRAEP
KDDMVTALVEAQAKNPGIATDDELVGVLFSLVTAGHQTTTYLIGNSVLALHEHPDQLA
RLKADPSLWPQAVRELQRLGPIQFGQPRFATEDIEVGGTVIPRGMPVVPLIMAANSDP
RKFPEPEKLQIDRLAVGSESHLGFGKGIHRCLGQHVAYLEAEVALRGLYTRFPDMTLA
VPREEIPWILRPGFTRTKDLPVRLARPAS

CYP107R1 Streptomyces maritimus

MTTHTQQLRDFPFAPPAELHMEPAFAQLREEEPISRVRLPYGGE
AWLVTRYQDIKTVLGDPRFSRAATQHAQAPRIQPDPAGEGVLMSLDPPDHTRLRKTVA
GVFTKRRVEDLRPATQRIAEELLEAMEASGAPADLVASYALPLPVTVICDLLGVPGDD
REQLRGWSDALLSTTACTPAESAAAAQAMADHFAALVSQRRRQPTDDLLGALVQTWDR
EEGLLRDEELVLLTRDLLIAGHETTASQIANCTYLLLQRPHDMDRLRTDPSAMASAVE
ELLRFIPLGSGSFRARVATEPVELCGVRIQPGDTVFAPTVAANWDPDVFAEPGRLDID
RSPNPHVAFGHGVHHCLGAQLARLELQVALGVLLRRLPRLRLAVDEAEIVWKTGMQVR
GPKTLPVKW

CYP107S1 Pseudomonas aeruginosa

VPDRKLRLGEELISPLHALYDGLQVDGAPRPAHRAAEHPVWVVTRYRDAR
KVLNHPGVRRDARQAAELYAKRTGSPRAGIGEGLSHHMLNLDPPDHTRL
RSLVGRAFTPRQVERLQPHIERITEALLDAMAGREQADLMADFAIPLTI
AVIFELLGIPEAEREHARQSWERQAELLSPEEAQALADAQVDYLRVLLE
AKRRQPADDVYSGLVQAADESGQLSEAELVSMAHLLMMSGFETTMNMIG
NALVTLLVNPEQLALLRAQPELLPNAMEELVRHDSPVRASMLRFTVEDV
ELDGVTIPAGEYILVSNLTANHDAERFDDPDRLDLTRNTDGHLGYGFGV
HYCVGASLARLEGRIAIQRLLARFPDLQLAVPHAELQWLPITFLRALIS
VPVRTGCSAPANTASHANPIERIAQ*

CYP107T1 Streptomyces coelicolor

MGSAPRLIVSLTGGPMTAPTYEELAALRAVGAVHRVFVPGSGESRLVVTRDAARAALTDPRL 16234
16235 RNDIRHSASWDSDGGHAIGHNMLQSDPPQHTRLRRLVAGHFTPGRTAALRPRVERIAHDL 16414
16415 LDALPPAGTADLVARYALPLPVTVICELLGVPESDRGTFHTWSNELVMPTSPEAAGSA 16588
16589 ATALTGYLTELTDAKRRTPDGTLLGDLVAAADSGELTPGELLGMAFLILVAGHETTVN 16762
16763 LISATVHGLLTHPGQLARLRAEPELTEAAVEESLRYHSPVHASAFRFAAEPLELAGTAIA 16942
16943 AGDPVLVSLAAASRDPAHFPDPDRFDIGRRPRGHLGFGHGPHHCLGAPLARVEAAVAVRL 17122
17123 LLDRHPALALAAGPATLTWRTSTLLRGLVELPVRLG* 17233

CYP107U1 Streptomyces coelicolor

MTGSSSAPVPELFSWEFASDPYPAYAWLREHAPVHRTRLPSGVEAWLVTRYADAKQALADP 8557
8556 RLSKNPAHHDEPAHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEF 8377
8376 APRVQELADGLIDRFADTGSADLIHDFAFPLPIYAICDLLGVPREDQDDFRDWAGMMI 8203
8202 RHQGGPRGGVARSVKKMRGYLADLIHRKRAALPPEPAPGEDLISGLIRASDHGEHLTEN 8026
8025 EAAAMAFILLFAGFETTVNLVGNGTYALLTHPEQRERLQTSLAAGERGLLETGVEELLRY 7846
7845 DGPVELATWRFATRPLTIGGQDVAAGDPVLVVLAAADRDPERFTDPDTLDLARRDSQHLG 7666
7665 YGHGIHYCLGAPLARLEGQTALATLLTRLPDLRLAADPAELRWRGGLIMRGLRTLPV 7495
SFTPPASSAGNGPSPTQK*

CYP107U2 Streptomyces avermitilis

MAGSARRRGRHGGGVGTVAGSAAGTRRLQRERGSRYRHPVNAPH
SEPELFTWEFATDPYPAYAWLREHAPVHRTTLPSGVEAWLVTRYADAKQALADARLSK
NPVHHSEDAPGKSKTGIPGERSANLMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAP
RVQELTDHLIDQFAQTGSADLIHEFAFPLPIYAICDLLGVPREDQDDFRDWAGMMIRH
GGGPRGGVARSVKKMRGYLAELIHRKREALPADPGPGEDLISGLIRASDHGEHLTENE
AAAMCFVLLFAGFETTINLIGNGTYALLRNPQQRARLQQSIERGEQDLLDTGIEELLR
YDGPVELATWRYATEPLDMGGQRIASGDPVLVVLAAADRDPARFDEPDTLDLSRSDNQ
HLGYGHGIHYCIGAPLARLEGRTALATLLRRLPDLRLAADPADLRWRGGLIMRGLRNL
PVEFTAT

CYP107U3 Streptomyces peucetius

MTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDAFIDKGEADLIHEFAF
PLPIYAICDMLGVPREDQDDFRDWAGMMIRHGGGPRGGVARSVKKMRGYLAELIHRKREQ
PGDDLISGLIKASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGVYALLCNPEQRERL
QASLAAGERGLLETGVEELLRYDGPVELATWRFATEPLTVGGQRIAAGDPVLVVLAAADR
DPERFADPDTLDLSRSDNQHLGYGHGIHYCLGAPLARLEGQTALATLLRRVPDLRLTGDP
ADLRWRGGLIMRGLRTLPVAWGAGGAPGGIKPGTAQTN*

CYP107U4 Streptomyces scabies SCAB54411

MTNQPAPSSA VPTGTGAPEL FTWEFATDPY PAYAWLREHA PVHRTRLPSG VEAWLVTRYG
DAKQALADGR LSKNPAHHAE PAHARGKTGI PGERKAELMT HLLNIDPPDH TRLRRLVSKA
FTPRRVAEFA PRVQELTDRL IDGFADRGEA DLIHEFAFPL PIYAICDLLG VPREDQDDFR
DWAGMMIRHG GGPRGGVARS VKKMRGYLAD LIHRKREGLT DHPAPGEDLI SALIRASDHG
EHLTENEAAA MAFILLFAGF ETTVNLIGNG TYALLTHPEQ RARLQTSLAA GETGLLETGV
EELLRYDGPV ELATWRFATE PLTLGGQDIA PGDPVLVVLA AADRDPARFD DPDTLDLSRR
DNQHLGYGHG IHYCLGAPLA RLEGQTALAT LLTRLPDLRL AVDSADLRWR GGLIMRGLRT
LPVEFTPRKR S

CYP107U5 SBI_8392 Streptomyces bingchengensis

80% to CYP107U2 Streptomyces avermitilis
MSDRHHPACSPALFSWEFAADPYPAYAWLREHAPVHRTTLPSGVEAWLVT
RYADARATLADPRLSKNPIHHSEAAHAKGKVGIPGERSADLMTHLLNIDP
PDHTRLRRLVSKAFTPRRVAAFAPRVQELTDGLIDGFQRRGEADLIHEFA
FPLPIYAICDLLGVPREDQDDFRDWAGMMIRHGGGPRGGVARAVKRIRAY
LADLIHRKRESLRENAEGKAGEKADDLISGLIRASDHGEQLTENEAAAMC
FVLLFAGFETTVNLIGNGTYALLRDPAQCDRLRRAAQEGDEGLLATGVEE
LLRYDGPVEISTWRFATEPVVIGGQRIAAGEPVLVVLAAADRDPERFDSP
DVLDLSRADNQHLGYGHGIHYCLGAPLARLEAQTAIGTLLRRLPDLRLAV
EPEEIRRRGGLIMRGLRELPVTWGPII

CYP107U8 SGR4436 Streptomyces griseus

MNDSPAPRPSEPSACPHSPAGPHGAPELFTWEFATDPYPAYAWLREHRPVHRTALPSGVEAWLVTRYGDAREALADARLSKNPANHAESPHAKGKTGIPGERKAELMTHLLNIDPPDHTRLRRLVSKAFTPRRVAEFAPRVQELTDRLIDDFVEKGSADLIHDFAFPLPIYAICDLLGV
PEEDQDDFRDWAGMMIRHGGGPRGGVARSVKKMRGYLAELIHRKRENPGDDLISGLIRASDHGEHLTENEAAAMAFILLFAGFETTVNLIGNGTYALLRHPGQRARLEASLAAGESALLATGLEELLRFDGPVEMATWRYATEALTLGGEEIAAGDPVLVVLAAADRDPARFTDPD
TLDLARRDNQHLGYGHGIHYCLGAPLARLEGQTALTTLLRRLPDLRLAGEPGDLRWRGGLIMRGLRTLPVAFEPGSRTRKSDTASTL

CYP107V1 Streptomyces avermitilis

MSGASARCPFSGAGGGTDVLPLPADPGTAAGAPAPGPPDAPAAP
APRTADRSAPHAADPHAPSTADLPRFPFPGLSGIPLDPVLLDRYRGEPLVPVGLANGR
EALLVTRYADVRTVLSDDRFSREAWANGTLFARRSGALALVTSDAPTHTRRRSRVQSR
FTHRRAEEDRPRIARIAAELLDSLQAADTGRPVDLIAEFTTPFPYRVICEMLGVPVAD
LDRLLPSVTVMMSAGRFSADEAARAHEVMYGYFFGQLAARREAIAAGCPGDDLLTSLL
SAPRETRLSDEEIVVFGFGLMMAGGETTASHLAMCVLQVLGTPGLADRLRRDASAVPA
VVEELLRWVWFAGTGGQPHVALEDVELAGRVLPAGQVVIPLTDAANRDPGVFPDADEF
RPDRAPNPHIGFGHGRHMCLGAAHARVELQEGLTAVLERLDHLELAVEPAELRWRDQM
FMRGVWELPVRWHTKEDGRC

CYP107W1 Streptomyces avermitilis

MAEAPSEPIAFPFPDPPSVCELPPELAEIRDGQSVVEVKFPDGI
SGWMVTKHADVRKVLVDSRFSSKVMATAAAAMSETETGKLMNESLVGMDAPEHTRLRK
LVTKAFTARRVETLRPRITELVGQLLDELETLPRPVDLVKNFSVPLPVRVICELLGVP
AGDQDTFHAWSNALLGDWQQVVEKEAATVSLVNYFGELIAVKRENPADDLISELIAIS
DGDSTLTEREIIALSIGILSAGHETTANQISMFLVTLLHNPEELDKLRDNREAIPKAV
DELLRFVPLTTTGGIIPRLTTAEVELSGGQVLPAGAVVLPAVATANRDPEVFEDGERL
NVTRENNPHLAFGAGIHHCLGAQLARIELQEALGAILDRMPQVRLAVPESELRLKSAS
IIRGLESLPITW

CYP107X1 Streptomyces avermitilis

MDPAEGLLADPYAVYDRLRDTAPVHRIAGTDGKPAWLVTRYDDV
REGLANPLLSLDKKHALPGNYRGLALPPALDANLLNMDAPDHTRIRRLVGRAFTLRRV
EQLREPVRETAHRLLDALGTHGSTDLIASYAAPLPITVICDLLGVPDEHRRDFRAWTD
PLVTPDPARPDVARESVVSLLGFFTGLLADKRKNPADDLLSDLIAVQEEGDRLTEDEL
MSLAFLILFAGYENTVHLIGNAVLALLRHPEQLAALREDPARLPDAVGEFARYEGPAL
LAIRRFPVRDVTIGGVTVPAGETVLLSLSAANRDPSRFPDPDRLDLGRDAAGHLALGH
GVHYCLGAPLARLETEVALAALLERFPDLALAETEPRRRPSLRARGLLALPVTY

CYP107X2 Saccharopolyspora erythraea NRRL23338

MRPVEIDDEFVTCPHAAYARLREQGPVHRAVAPDGSRVWLVTRYDDVRAALADSRLSLDK
AHATDGYRGLSLPPALDANLLNMDAPEHTRLRRTVTRAFTAHRTELLRPRVQEIADELLA
AVAGQERAELMSAFAGPLPITVICELLGVDARDRPDFRAWTDEMLAPSTPDRARDSLRSL
YAFLVDLIARKRAEPGADMPSTLVGLRDEDGSLTEDELTSTAFLVLFAGYENTVNLIGNG
LAALLARPAQLAAVRSDRGLLPSTVEELLRFDPPPQLSIRRFPKEDLEIGGVRIPAGDTV
LLSLVSAHHDPARFTSPGELIPDRADNAHLAFGHGPHFCIGAPLARMEAEVAFSTVLTRF
PALSLAVDPAELRWRPSFRNRGLRELPVRLS

CYP107X3 SBI_2046 Streptomyces bingchengensis

67% to CYP107X1 Streptomyces avermitilis
MQNTANTAVPGPPEPFDTRVLLEDPHTAYAELREAGPVHRIPGPDGRPAW
LVTRYDDVRRALADPRLSLDKSNALPGNFRGFALPPALDANLLNMDPPDH
TRVRRLVTKAFTPGRVERMREPVRRAADELLDAVEPAGRADLIAAYAGPL
PITVICDLLGVPQRDRRDFRAWSDALIAPDPERPHVAKEAVGNMLRFYTG
LIASKREEPGDDLLSDLIAVRDDAVGGAGEGGDRLTEDELTSLAFLLLMA
GYENVTHLIGNAVLSLLDHPPLLRELRERPAGIAAAGGXAVEEFARHDGP
APLAIRRFPLEDVEIGGVTVPAGETVLLSLASANRDPGHFKEPDRLDPDF
GRLGHLAFGHGIHYCLGAPLARLEAETALAALLSRLPRLRLDISHTELRR
RPTIRARGLISLPVAW

CYP107Y1 Streptomyces avermitilis

MDFGADPYPEYAWLRAEEPVRQVLEGRGLYGLLVTRYEDVRKLL
SDPRMSKDPRNAPLDWQEAGKGRPLEDRTGLGTHLLTTDAPEHTRLRRLVSTAFTARR
VEGLRAQVQHITDGLLDTIVPRGQAELIGDFAFPLAITVICELLGVPKADQDVFRQWT
KDFRRWTNTDSAQADRGDARPVGLRDLLEYLTRLVDKRRQDPADGLVDALIAARDDDD
RLNEAELLSMMSLLLVGGFETTVNLIGNGTLALLRHPDQLALLRERPELVDSALEEML
RYDGSFETATWRFPLEPIEVAGTRIEKGHPVLLSLASANRDGAKFPAPDDFDVTRADP
AHVAFGRGAHFCLGAPLARLEGRIAFHGLLRRLPGLALSVPPEQLRWQRSLTVRGLEA
LPVTFDA

CYP107Z1 Streptomyces rimosus ssp. paromyceticus strain R-2374

MTTSPTESRAATPTGSTASPSTASAPATTPSAATSSDTTYPATTDRTTLPSYVGLHPGEPNLMEPELLDNPYTGYG
TLREQAPLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADKDPRARLIELFGIPEDLTPYLADTIL
TSDPPDHTRLRRLVSRAFTARRIQDLRPRVEQITDALLERLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDR
TLWRRFGADLASLNPKRIGATMPEMIAHIHEVIDERRAALRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGH
ETTAHLISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYAMEDTEVAGVQVRQGEALMFSLVA
ANHDPRHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLELALTPEQLEDQERL
RQPGTWRLRRLPLKLHARS

CYP107Z2v1 Streptomyces albofaciens strain C-0083

MTTSPTESRAATPPDSTASPSTAAAPATTPSAAASPDTTSPATTDRTTLPSYVGLHPGEPNLMEPELLDNPYTGYG
TLREQAPLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADQDPRARLIELFGIPEDLAPYLTDTIL
TSDPPDHTRLRRLVSRAFTARRIQDLRPRVERITDELLARLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDR
ALWRRFGADLASLNPKRIGATMPEMIAHIHEVIDERRADLRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGH
ETTAHLISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYAMEDTEVAGVQVRQGEALMFSLVA
ANHDPRHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLALALTPEQLEDQERL
RQPGTWRLRRLPLRLHAES

CYP107Z2v2 Streptomyces rimosus ssp. paromyceticus strain BOEH-4355

MTTSPTESRAATPPDSTASPSTASAPATTPSAAASPDTTDRTTLPSYVGLHPGEPNLMEPELLENPYTGYGTLREQ
APLVRARFIDDSPIWLVTRFDVVREVMRDQRFVNNPTLVPGIGADKDPRARLIELFGIPEDLAPYLTDNILTSDPP
DHTRLRRLVSRAFTARRIQDLRPRVERITDELLERLPDHAEDGVVDLVEHFAYPLPITVICELVGIDEEDRALWRR
FGADLASLNPKRIGATMPEMISHIHELIDERRAALRDDLLSGLIRAQDDDGGRLSDVEMVTLVLTLVLAGHETTAH
LISNGTLALLTHPDQRRLIDEDPALLPRAVHELMRWCGPIQATQLRYALEDTEVAGVQVRQGEALMFSLVAANHDP
RHYTGPERLDLTRQPAGRAEDHVGFGHGMHYCLGASLARQEAEVAYGKLLTRYPDLALALTPEQLEDQERLRQPGT
WRLRRLPLRLHAQS

CYP107Z3 Streptomyces sp. strain IHS-0435

MTELADSPFSEHVGKHPGEPNVMEPALLTDPFTGYGELREQGPVVRGRFADDTPVWFITRFEEAREVLRDHRFANA
PAFAAGGGSGDTPSNRLMEIMGLPEHYRVYLANTILTMDAPDHTRIRRLVSRAFTARKITDLRPRVEDIADDLLRR
LPEHAEDGVVDLIKHYAYPLPITVICELVGIPEEDRLQWRDWGSAFVSLQPDRLSKAFPAMIEHIHALIRERRAAL
TDDLLSELIRVHDDDGGRLSDVEMVTMVLTLVLAGHETTAHLIGNGTAALLTHPDQLHLLKSDPELLPRAVHELMR
WCGPVQMTQLRYATEDVEVAGVQVKQGEAVLAMLVAANHDPRHFADPARLDLTRQPAGRAENHVGFGHGMHYCLGA
SLARQEGEVAFGNLLAHYPDVSLAVEPDALQRVPLPGNWRLAALPVRLR

CYP107Z4 Streptomyces lydicus strain NRAB-0114

MSASTSSPLSAHVGKHPGEPHVMDPALISDPFGGYGALREQGPVVRGRFFDDSPLWLVTRFEEVRQVLRDQRFVNN
PADPALGVAPEDSPQLRALAMLGIPEHLHGYLLNSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVAQITAELLD
RLPEHAEDGVVDLIEHFAYPLPITVICELVGIAAEDRPQWRSWGADLVSVDPDRLGRTFPAMIDHIHALIGQRRAA
LTDDLLSELIRTHDDDGSRLSDVEMVTLVLTLVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHVTQLRYAAEDVDLAGTRIRRGDAVQAVLVSANHDPRHYTDPERLDLTRQPAGRAENHVGFGHGAHYCLG
ASLARQEGEVALGALFDRYPDLALAVAPEELERTPVPGTWRLTSLPVRLG

CYP107Z5V1 Streptomyces lydicus strain NRRL-2433

MSALPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFVDDSPVWFVTRFEEVREVLRDQRFRNN
PVSSAPDADPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVAQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRKGDAVQLILVSANRDPRHYTEPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPDALERTPVPGSWRLNALPLRLR

CYP107Z5v2 Streptomyces chattanoogensis DSM-40241

MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN
PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPDALERTPVPGSWRLNALPLRLG

CYP107Z5v3 Streptomyces lydicus strain R-401

MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN
PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPEALERTPVPGSWRLNALPLRLR

CYP107Z5v3 Streptomyces kasugaensis strain A/96

MSASPSNTFTEHVGKHPGEPNVMDPALIGDPFAGYGALREQGPVVRGRFMDDSPVWFVTRFEEVREVLRDPRFRNN
PVSAAPGAAPEDTPLSRLMDMMGFPEHLRVYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVTQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEEDRPQWRTWGADLVSLQPDRMSRSFPAMIDHIHELIAARRRA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYAAEDVELAGVRIRTGDAVQLILVSANRDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVALGALLRHFPELSLAVAPEALERTPVPGSWRLNALPLRLR

CYP107Z6 Streptomyces sp. strain I-1525

MSALSSSPFAEHIGKHPGEPNVMEPALINDPFGGYGALREQGPVVRGRFMDDSPVWFVTRFEEVRQVLRDQRFVNN
PASPLLGSQVEEMPMVKLLEQMGLPEHLRVYLLGSILNSDAPDHTRLRRLVSRAFTARKITGLRPRVEQIADELLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRAWGADLVSLEPDKLSTSFPAMIDHTHELIRQRRGA
LTDDLLSELIRAHDDDGSRLSDVEMVTMVFALVFAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRYASEDIDLAGTPIRKGDAVQLILVSANFDPRHYSDPDRLDLTRHPAGHAENHVGFGHGMHYCLG
AALARQEGEVAFGKLLAHYPDVALGVEPEALERVPMPGSWRLNSLPLRLAKR

CYP107Z7 Streptomyces tubercidicus strain DSM-40261

MSAISSSPFAAHVGKHPGEPNVMDPALITDPFGGYGALREQGPVLPGRFMDDSPVWLVTRFEEVRQVLRDQRFLNN
PAASSPGHSIDESPTARLLDMMGMPEHFRPYLMGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVEQLADELLA
RLPEHAEDGVVDLIKHFAYPLPITVICELVGIPEADRPQWRKWGADLVSLQPERLSTSFPAMIEHIHELIRERRGA
LTDDLLSELIRTHDDDGSRLSDVEMVTMVLTVVLAGHETTAHLIGNGTAALLTHPDQLRLVKDDPELLPRAVHELL
RWCGPVQMTQLRYASEDVEIAGTPIRKGDAVQLILVSANFDPRHYTAPERLDLTRHPAGHAENHVGFGHGMHYCLG
ATLAKQEGEVAFGKLFTHYPELSLAVAPDELERTPVPGSWRLDSLPVRLG

CYP107Z8 Streptomyces platensis strain Tu-3077

MSALSSSPFAAHVGKHPGEPNVMDPALIADPFGGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFLND
PTAPSLGRSFDDSPTARLLEMMGLPEHFRPYLLGSILNNDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLT
RLPEYAEDGVVDLIKHFAYPLPIAVICELVGIAEADRPQWRKWGADLVSLQPDRLSTSFPAMIEHIHELIRERRGA
LTDDLLSELIRAHDDDGGRLSDVEMVTMILTVVLAGHETTAHLIGNGTAALLTHPDQLRLLRDDPALFPRAVHELL
RWCGPVHMTQMRFASEDVDIAGTKIRKGDAVQLILVSANFDPRHYTDPERLDLTRHPAGHAENHVGFGHGMHYCLG
ATLAKQEGEVAFEKLFAHYPEVSLGVAPEQLERTPLPGSWRLDSLPLRLR

CYP107Z9 Streptomyces tubercidicus strain NRAA-7027

MSALSNSPLAAHVGKHPGEPNVMDPALITDPFGGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFVNN
PAAPSLGRSIDESPAVRLLEMLGLPDHFRPYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQITDDLLT
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIAEADRPQWRKWGADLVSLEPGRLSTAFPAMVEHIHELIRERRGA
LTDDLLSELIRTHDDDGGRLSDIEMVTMILTIVLAGHETTAHLIGNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVHMTQLRFASEDVEVAGTPIHKGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGMHYCLG
ATLAKQEGEVAFSRLFTHYPELSLGVAADQLARTQVPGSWRLDTLPLRLG

CYP107Z10 Streptomyces tubercidicus strain I-1529

MSALSSSPFAAHVGKHPGEPNVMEPALLTDPFAGYGALREQAPVVRGRFVDDSPVWFVTRFEEVRQVLRDQRFVNN
PAAPPLAPSAEENPLTRLMDMLGLPEHLRVYMLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLA
RLPEYAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRKWGADLISMDPDRLGATFPAMIEHIHEMVRERRAA
LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVQMTQLRYAAADVDLAGTRIHKGDAVQLLLVAANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLAHYPEMSLGIEPERLERLPLPGNWRLNSLPLRLG

CYP107Z10 Streptomyces platensis strain I-1548

MSALSSSPFAAHVGKHPGEPNVMEPALLTDPFAGYGALREQAPVVRGRFVDDSPVWFVTRFEEVRQVLRDQRFVNN
PAAPPLAPSAEENPLTRLMDMLGLPEHLRVYMLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADELLA
RLPEYAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRKWGADLISMDPDRLGATFPAMIEHIHEMVRERRAA
LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLLKDDPALLPRAVHELM
RWCGPVQMTQLRYAAADVDLAGTRIHKGDAVQLLLVAANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLAHYPEMSLGIEPERLERLPLPGNWRLNSLPLRLG

CYP107Z11 Streptomyces platensis strain NRAA-7479

MSALPTSPFAAHVGKHPGEPNVMDPALITDPFTGYGALREQGPVVRGRFVDDSPVWLVTRFEEVRQVLRDQRFVNN
PAAPSLGHAAEDNPLTRLMDMLGLPEHLRPYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADALLA
RLPEHAEDGVVDLIRHFAYPLPITVICELVGIPEADRPQWRTWGADLVSMEPDRLTASFPPMIEHIHRMVRERRGA
LTGDLLSELIRAHDDDGGRLSDVEMVTLILTLVLAGHETTAHLISNGTAALLTHPDQLRLLQDDPALLPRAVHELM
RWCGPVQMTQLRYAAADVDLAGTTIHRGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLAHYPEMALGVAPERLERTPLPGNWRLNALPVRLG

CYP107Z12 Streptomyces tubercidicus strain R-922

MSELMNSPFAAHVGKHPGEPNVMDPALITDPFTGYGALREQGPVVRGRFMDDSPVWLVTRFEEVRQVLRDQRFVNN
PASPSLNYAPEDNPLTRLMEMLGLPEHLRVYLLGSILNYDAPDHTRLRRLVSRAFTARKITDLRPRVEQIADALLA
RLPEHAEDGVVDLIQHFAYPLPITVICELVGIPEADRPQWRTWGADLISMDPDRLGASFPAMIEHIHQMVRERREA
LTDDLLSELIRTHDDDGGRLSDVEMVTMILTLVLAGHETTAHLISNGTAALLTHPDQLRLVKDDPALLPRAVHELM
RWCGPVHMTQLRYATADVDLAGTPIRQGDAVQLILVSANFDPRHYTDPDRLDLTRHPAGHAENHVGFGHGAHYCLG
ATLAKQEGEVAFGKLLTHYPDISLGIAPEHLERTPLPGNWRLNSLPVRLG

CYP107AA1 Mycobacterium smegmatis

MTPYSRRDRNH
MLRLGNSFVQNPHEVYDRLRRSGPVQRVEMWGGVPVWLVTRYQEARNLLT
DPRIGKDGAAASALFPPGTDGSIGTVLGDNMLFRDPPDHTRLRRFVTSAF
TAHAVRRLRPTIAGFADALLDDIAASVPGQVDLLQAFAQPLPVQVIGELL
GVPERDRELFAALVVPIFTSTDTTVLRRAQKELTQLLTDMLAEKRQSPAD
DVLSSLVHRRDGTDQLSEAELLGTAFLLIVAGYETTVNLLANGILALLRN
PEQLRAVRADRSLLPRAVEEALRFESPLNTATVRYTSAPVTVGDVEIPSG
ELVVIGLLAANHDDEQFPDAHRFDVSRTHNRHLAFGYGVHHCVGAPLARM
EAEIGFDRLLSRFEVMELVDSGPPRYRPSTLMRGVERLPVILGYPHDIAS
TMREWSGSLPSSGEADSSFAH

CYP107AB1P Mycobacterium smegmatis

MILDEQFAQDPEGLYRMLRSEAPVCEVELIGGVRGWLVTRYADVMALLKD
PRVSKDHTSALPRLAPDRVRPYISPQLHNHMLNLDPPEHTRLRRLVVQAF
TPKALARMQPVIDAIADELLDDIDLRSGDEPIDLMADYAEPLPIQVIAEL
LGVAVEYA*PFRAAVTPLLMSVTVEEKAESGRATIEILNAVIDEKIREPG
EDLLSGMIGASVDGHGLTRDELMAMCFLLITAGYETTVNLIGNGTLALID
NPSQLEKVRENPDLTAGAVEEILRFDGPVNIATWRYATADIDVDGVVIPA
NEQIFLSLLSANRDTGRFENADRFDIERNTRGHIAFGHGIHYCLGAPLAR
MEGVTAIGRIVQRYDSITLDPTAELRYHNGTLMHGLKSLPVRLTRVPQPRP

CYP107AC1 Streptomyces atroolivaceus

MSATRRVHIYPFEGEVDGLEIHPKFAELRETDPLARVRLPYGGE
GWMVTRYDDVRAANSDPRFSRAQIGEDTPRTTPLARRSDTILSLDPPEHTRLRRLLSK
AFTARRMGAMQSWLEELFAGLLDGVERTGHPADIVRDLAQPFTIAVICRLLGVPYEDR
GRFQHWSEVIMSTTAYSKEEAVSADASIRAYLADLVSARRAAPHDDLLGVLVSARDDD
DRLTEDELITFGVTLLVAGHETSAHQLGNMVYALLTHEDQLSLLREQPELLPRAVEEL
LRFVPLGNGVGNARIALEDVELSGGTVRAGEGVVAAAVNANRDPRAFDDPDRLDITRE
KNPHLAFGHGAHYCLGAQLARMELRVAIGGLLERFPGLRLAVPADQVEWKTGGLFRGP
QRLPIAW

CYP107AD1 Streptomyces hygroscopicus

MSGRHFEQGERGTAMADTPEEELRILDPQSVAQELRKHGPPRQI
TMHGTTAWLVSRYEEVRDCLGHPGMSPAAAYAASQGQTNPVSGLFEDTVAGTNPPQHT
RLRRLLAKAFTVRRVESLRPRVQEITDTLLDRIAVDGRADLVSALAIPLPMQVICELL
GVPIADRTEFHQWADLMLTPPLDPDTAARSQDASAKLWTYMEDLAEARRKAPEDDLIS
DLMSAHEDDRLSHREVVATARMMLIAGYELTGSFISNAVFSLLSQPDQMELLRKDPEL
AGRGLEELLRHAGPGILIVRFANEDVEIGSVSIRAGDQVLLDMDAAHSDPAHFTDGER
LDLTRDSAVHLQFGHGIHYCIGAPLARVEGQIALESLVRRFPGLRLSVPAAEISHSKN
PFIRSLTALPVEFEAQQPVAG

CYP107AE1 Streptomyces sp.

VILLKSLAANGLTASSCFTVSPLPIRSASPSIAFLTSSSERDSGVRNDRPSDAQPAIARF
RFPTPPHPRNPTQPHPTPPRPSPTDDPLQAPTFFADPYPTYARLRDTAPVLKVPTGSGGG
GRHSYVVTGYAEAREAFTDPRLSKDTASFFAGRPSQRDLHPAVSRNMLATDPPQHARLRA
LVTKAFTTGAVARLRPYISSLVDELLDTWPTHGTVDLIADLAVPLPVTVICELLGVPDSD
RASVRTWSSDLFAAGDPQRIDAASHAVGDYMTALVAAKRTAPGDSLLDDLIAVRDGQDHL
SEDELVSLAVLLLVAGHETTTNFIGNAALALLRHPESLAHLRAEPQLLGGALDELLRYDS
PVGIATFRFSTEALTLGGTEIPEGVPVLIAPGAANRDPDRFPDPDRLDLTRGATGHLAFG
HGIHRCLGAPLARAEAELALHAVITRYPQAALATPPETLPWRHTRLTRGLASLPITLRDH
PK*

CYP107AE3 SGR420 Streptomyces griseus

69% to CYP107AE2
MNDASEDSRSAPDLSSGCTAPRPRCPVRAVTSGSDGRESYLVTGYAEARDALSDVRLSKDTAAFFAGKGSRRRLHAAVAHTMLASDPPRHTRLRKLVTGAFTSGSIAALRPSIARLTDELLDRWPAGGAVDVVAALAVPLPVMVICELLGVPETDRPRVQRWSADLFAAGDPGRTD
AASHAVAAYMTGLIVSKRLHPGDSLLDRLIAARERGDRLGEEELVSLAVLLLVAGHETTTNFLGNAVLALLRHPAELNRLRGDPGTIPRALDELLRFDPPVSTSTFRFATEAMSLGGTEIPAGVPVLVDINAANRDPERFTAPDRLDLDRDATGHLGFGHGIHRCLGAPLAKAEAHIAL
RAILTRFPDIRLAVAADRLDRRRTRLISGLDSLPVLL

CYP107AF1 Streptomyces collinus DSM2012

MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPN
GLRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPH
VLSVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLME
ALAFPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEA
KRNEPADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHP
EVREQLAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGA
AGRDPDRYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLR
LAADPDELSWRSSLMMRGLEELPVFTA

CYP107AG1 Streptomyces atroolivaceus

MSTEVETEKPAPVAYPFTGSEGLELSQSYAKLFEDGDPIRVQLP
FGEPAWLVTRYDDARFVLTDRRFSRHLATQRDEPRMTPRAVPESILTMDPPDHTRLRT
LVSKAFTPRRIESKRAWIGELAAGLVADMKAGGAPAELVGSYALAIPVTVICELLGVP
EDDRTRLRGWCDAALSTGELTDEECVQSFMDLQKYFEDLVKERRAEPRDDLTSALIEA
RDAHDRLAEPELIGLCISILIGGFETTASEISSFVHVLQQRRELWTRLCADPEAIPAA
VEELLRFVPFAANGISPRYALEDMTVGGVLVREGEPVIVDTSAVNRDGLVFDNADEVV
IDRADNRHMVFGHGAHHCLGAHLARVELQEALKALVEGMPGLRLSGDVEWKADMIIRA
PRVMHVEW

CYP107AH1 Streptomyces peucetius

VTTTQDPVTAAERCTADFRRNPHPVYASLRDTAPVCPMKPPHGVETYLITRYEDARAALS
DPRLSKDMYGAMDAYRRIFGDSSVSLDDNMLNADAPKHTRLRRLVNSEFTPRRVEALRPK
IQDIVDQLLDACPTGEPVDLLPAFAFPLPITVICELLGVPAEERPHMQRLSTTVAQTGFS
KESKQAQQKAEEDLHSYFTQLIARKRERPGEDLLSALTEARDKDGGLSENELVSTAFLLM
FAGHKTTAYLIGNAVHHLMANPAQLRAVRENPELVGPAVEELVRYDGSVESATFRFATED
VEIGGTRIPKGALVQISLLSANRDPRKFESPDEFDVRRPGNAQSGHLGFGHGSHYCLGAP
LARLEMQLALTTLFGRFPAIAPADPSAEAKWMEVPFPAFRGLAELPVVLCPES*

CYP107AJ1 Streptomyces peucetius

MVNTGGEMPLATERLGDSFFQDPQGLFARLRSSAPVTPVITPEGTRVWLVTRYEDVRAAL
ADPRLAKDWVTHMTPDDFDINVDPVQAYLDQHMLNLDPPDHTRLRRLVVKAFTPRRVAAL
RPRISAVNGELLDAMADGPAETDLIEAFAFPLSVTVICELIGIPVGDRESFREWSGTLLS
SRGTREESRAAAVDMYEYFTRMVAERRRSPADDLLSALIAARDSGDSLSEHELLSMVFLL
LVAGHETMVNLIASGVLALLTHPAELGRLRDDPSLLPSAVEELLRYANPLNHATERFTLE
PVTIGDAIIPAKEWVMLATSSANRDASRFAD
ARPAGRGPGRVGPRRVRARDPLLSRRATG
AAGGRDRVRDAAVPVPGADAGGARVVAEVAALQPHPRAGGPPRPTALTRAGETCPARPDE
LGSTVDVADPKGRRPALPADG*

CYP107AK1 Streptomyces scabies SCAB79691

MVLGAEFVRN PHEVNARLRE QGAVHEVVMP TGLKVWWVTR WEEGRALLAD ARLSKNVADA
GKLFERHQSD MSRQRDYSHV INRSMVNMDP PDHTRLRGLV AKAFTMRQVT GLRPWIEKIA
DEVLGSLEGR VEFDVIADFA VPMVRTVISE FLGVPVADRA EFCAHAAVLT SDGDRESAAE
ASNALAELVS RIVTAKRADL GEDLLSSLIL AADGSDRLSD DEIISFTVLL FVGGFDTTVN
LLGNGMLALL RNPDQLAAVR DDPALLAGAV EEFLRYDGSA NISHWRRTVE PVTVGEVTIP
AGEFVFIALG SANRDPARFP EPDRLDVTRS AQGHLAFGHG IHHCIGAPLA RAEGEIAFRR
LLARFPSLEL TVDPEELEWR PSMLHHGLRS LPVRTAQR

CYP107AL1 Streptomyces scabies SCAB63301

MDTASASPAG NGTDTETAYE YPFHRPSAVE VPPVYEELRA KCPVAKVRLP SGDEGYVVSR
YDDARVVLAD PRFSRAAMLD EGAPRLTAAP PMPGSLFTMD APEHTRVRRL VSREFTARRV
QNLRPRIQQM TDELLDDMEK LSPPVDLNPA FAFPLPVMVI CELLGVPFED RDRFRGWSDA
FVSLTAHTAE EVMEQRMSMV QYLAQLVQRK REEPADDLMS ALVAVHDEDG DRLSEHELIT
MGITLLVAGH ETTVSMIGKC VLTLLRHPEH LAALRERPET IDQVVEELLR INPIGDGGPF
RVTLEDVEIA GTTIPKGSGV IAAVASANQD PERFGADSGV FDPARSSAGA HLALGHGAHF
CLGAALARAE LQIAVSSLIR RFPRLALADE VGNLSLTSGM MVHALSRMPV TW

CYP107AM1 Streptomyces scabies SCAB44031

MSQVETSGGT ASGSGTASGS GSGTSGGDRT RTGAPPDDEV IRLPMTGEGP LDPPAAWERL
RERCPVATVE LPSGDRAKFV SRYDDVRALL SDPRFARPRA GDDSARLSAD GSGGVATDAS
AAYPLAIPEA GEPHLRWRRQ VGRYFTAKRM AALRPGMTRI AGSLLDDMIE RGQPADLKAA
LGFPLPVYVI CELLGAPAED RDLFSHWSDA FLNVSRFSKE ETRTAFTEFT RYMADLVAAK
RSEPGEDLLS MLVVDSTALP EAERLTDAEL LATGMGLLVA GHETTANMIG KMAALLLADR
RRWEQLLADP SLVRTAVEEV LRFDANLSAF GMRRQLSEDV ALGREVLPGG TTVFCGMSSA
NRDDRVFSSP AEMDLTRSPN PHLTFGAGPH SCLGQALART ELQVALEVLL HRLPTLELAV
PPAELRRLEG LLVGGLREVP VRW

CYP107AM2 SBI_7397 Streptomyces bingchengensis

68% to CYP107AM1 Streptomyces scabies SCAB44031
MSQNDPTVRLPLPTDGPLDPPPEWELLRGRCPVATVELPSGDTGTLLTRY
DHIKALLSDPRFSRPAPEDDSARIAPEGAGGVSTNSGMSLSLQSNGEGHQ
RWRRHVGKYFTARRVTALRPGMEEMAETLIDAMVQSGSPADLKAALGFPL
PVYVICNLLGAPAEDRDRFSYWSDAFLNVSRYSVAETGAAHEDFVTYMSE
LIAAKRAEPSEDLISTLIEESRAEGEGLTDLELRDTGMALLVAGHETTAN
MIGKMVAMLLADRTRWDSLLADPSLIRTAVDEVLRSDANLGGYGVRRYLT
EDYEVDGAVLPGGTTVFCGLSAANRDERVFADPDEMDLTRSPNPHLTFGA
GAHSCLGQSLARTELQVVLEVLLHKLPSLDLAVPVARLRQIEGLTVGGLR
EVPVRW

CYP107AN1 Bradyrhizobium japonicum USDA 110

1 MVTPGSGAAI GVFVSCGNRF EVTMNEQAQP AGGDPLFNPL SPDFIRNPYP HYDRLRAIDP
61 IHVTPFGQFV ASRHADVSLV MRDKRFGKDF VERSKRRYSE KIMDEPVFRS MSHWMLQADP
121 PDHTRLRGLV VKAFTARRVE DMRPRIQEIV DEAIDAVIDR GHMDLIEDFA FRLPVTIICD
181 MLGIPEDHRE VFYKSSRDGG RLLDPVPLTP EEIAKGNAGN MMAQMYFQQL FELRRRNPAD
241 DLTTQLVQAE EDGNKLTNEE LTANIILLFG AGHETTVNLI GNGLLALHRN PDQLALLKAR
301 PELMVNAIEE FLRYDSSVQM TGRVTLEDID DLGGRKIPKG ETVLCLLGSA NRDPAVYPDR
361 PDRLDVTRPN VKPLSFGGGI HFCLGAQLAR IEAEIAIATL LRRLPDLRID DVENPEWRPT
421 FVLRGLKSLP ASW

CYP107AP1 Streptomyces rochei plasmid pSLA2-L

MNQPQLPEIPALNSELFHTDQYATYREILEQRPVTRVRFYDGSL
VWLVNRHEDVRAALTDPRLSNDPMKQSDIDLSAATGIPADLIEYFQRNMFRSDEPDHG
RLRKLVTREFTVRRINALRPRIRQIADDLLEKFAATGGGDLVEALARPLPLTVMCELL
GVPEEDRADFQTWSQHIVESSPEFAERNAVSYRSLFECVRSLIRRRRDEPGDDLLSAL
VDLRDVADRLSENELISTVFLLLVAGIETTVNVLGTGTFLLLTHPGELARLRADGALL
GPAVEEMLRYMAPIEITSRHTLEPVEIGGVSIDAQSTVLINLAAANRDPARFEDPQSF
RVDRNDGGHLTFGHGIHYCLGAALARAEAEVTFEALLERFPDLRLAASASDLTWRHAF
MRGPVELPVSWG

CYP107AQ1 Saccharopolyspora erythraea NRRL23338

MFDTADPAFVADPYPCFAELRRRGEVHRHPGLGMAVAVSHAAASEVLRHRGLGRIWVDAQ
PAADFPAFNLLHRTSLLETEGAEHTRLRRSISAAFARGHVERVRPWVAGLADALVGGLVE
RGGGDVVEEVAAPLPVQVIAELLGVPESDRNLLRPWSNAIVKMYEPGLPERRRAAAESAA
AEFAEYMRALADRRRSAPADDMVSDLVAAEELSADEVVGTAVLLLMAGHEASVNLVANGV
LALLRHPGQWRRLVDDPGLVPTAVEELIRYDSPLQLFERTAVEDVVVAGHRVAAGSKIAA
LLGAAARDPEVFESPDVLDVGRQPNPHLGFGAGIHYCLGAPLARVEAAAALSALVRLAPR
LEQAGEPVRRPEFVIRGLRELPVSV

CYP107AR1 Saccharopolyspora erythraea NRRL23338

VQPDQSPTPRPESRHSPAAACPHAAVHREERPGGLVTWQISAFSEARAALGDSRFSKDPR
RLGEALRAGGRSMFAEYGDNLLDNLLNSDPPDHTRLRRLVGKAFSPATIERLGPTTQRLA
DELVASMLPAGRADLLAQFAYPFAFGVIARVLGLPPDSYRIFQRWTESMTAPREQGTDRM
VAARHLCEHVTELVRRSREWLASAPAETLLDELVSARDDGDRLSENELVATVLLLIIAGH
ETTVNLIGNGVHALLQHPGQLALLRDHPDLIDGAVEELLRFQPPISKTTLRVTTTDVEVA
GTEIPAGSIVNVLVPAANRDQRQFPDADRLDITRPPSAHMSFGHGIHYCIGAPLARMEGR
IAIGALLRGLPGLRLAEPAAEIPWRASNILRGLQRLPVRFDSAGADDEVRDRRHAGAARV
HA

CYP107AS1 Saccharopolyspora erythraea NRRL23338

MTESIQRDADSQEAACPHARAYPFGDPGALDLDPDYARVRDEEPLTRIRMPYGEQGWLVT
RYDDVRTVLADPRFSRSEVLKRDVPRPTPQQVERPGTLVTTDPPEHGRLRRLVAGAFTHR
RAESMRPRIRGVVDELVDEMLAGDKPADLVAAVSMPLPVNVICELLGVPREDRHVFHSGA
VLSDYTVPADEREATFKSLADYLAVLIAERRARPEGPGDDVLGALISARDTDGDRLSEDE
LIELWVDILVAGYASIMSVTPDMVVTLLTERDRWDGLVADPGGVPDAVEEMLRVMPTIIE
SGHSRVATEDVEIAGGTVRAGEAVLPCLPAANRDPAVFDAAEEMRLDRDAGKHIAFGFGP
HYCLGASLARVQLQSVLTALVRKVPTLDLVEAVREDSTRVAAAVQGQLLVTW

CYP107AT1 Saccharopolyspora erythraea NRRL23338

MSVGDIDTPSGEFDFAANLLPFDPLDPAFQADPYPFFRLVRETAPALCTQPGMWVVTGFR
ECSAVLRNPKFGHGDGRLVASQITHDAEGNVVRPFVFMDPPDHTRIRSLVTKAFSARMVE
RLRPTAERLVGELLAAAMSGPADEPVDLMAELAFALPSNLISELLGMPPQDKPLFEQWSS
ALGRGLDPDFMLSPEEMQRRDQARTEFDGYFAELARRRRAEPADDLVSALVAVEEDGRNL
SMSELVSTCRLLLSAGYLSTAHLIGNGVNALLRHPEQFEWFRAHPDQVAGVVEELLRYDS
PVQTAGMRTALQDTEIGDQPVSAGEGAMLLVGAANRDPAAFPDPDRLDVSRKPERNLGFG
IGAHFCVGAPLARLTTQVALTALAGLRVELATDDAPRINNLVLRGFAELPVFLRAA

CYP107AT2 Saccharopolyspora erythraea NRRL23338

MSTTEGAPPVDSNVVRQLLLFDPFDPEFRADPHRVYREIRESGPVTATPGGLWLVSGHRQ
VSAVLRDQAFGWGEAELAAGHFTTDDEGNTVRPLTFADPPEHTRIRSLVTSAFSARIVER
LRPRAQELARESLAAALAGGGSADVIQQVAYPLTGRLLCELLGVDPEYQERFRAWAEAMG
RGLDPDFMQSPDQLARREEARAHFHEYFAELAARRRAEPGDDLVSALVAVEQEGDRLTAT
ELVVTCTLLLSAGYATTVHLIGNGMLALLENPDQLAWLRANPGRVGDAVEEVLRFDGPIQ
LVSRVALRDTEVDGHAVAAGSPVLLLLAAANRDPAVFDDPDRLDVSRKPGRNLGFGVGIH
FCLGAPLARLTAQAALSLLVEHELVLDGPRPAPTGSLVLRGLAELPLRSA

CYP107AU1 Saccharopolyspora erythraea NRRL23338

MTAGTNNAGRLGALAEAVLGYNPVDPEYHANAHEHHRRMAERGPIFRTPGGMWTAVSHAA
CSAVLRDDRFGHDPGSAAQNLFDSTQRPSVAQRSFEFMDGPDHSRLRRLVNRAFTARRVE
RLRPAVRTLADQLLTDVSGRIDVLADFILPLAMTTIVDMLGAPTEDNHLFRAWAEPIVRG
LDPDFLLSSSELAAREQANAEFAEYFDRLVALRRAEPKDDLISALIAVEDDGVVLSGNEL
ISMCLLLLAAGHESIMHLVGNGTVALLRDEDQLEHFRGHPGEVTNAVNELLRYDPPVVLL
VRTALADAEVLGNRVRRGEIVWLQIGAANRDPAVFPDPDRLDLTRDTGGSLAFGLGIHFC
IGASLARLEAAAALSALLHRDVALASEQLVHQKNVVIRGYEEVPVVLR

CYP107AV1 Saccharopolyspora erythraea NRRL23338

MTTAEPAETGSLAELNLGMRLVLHGAVTWSIARLGDPVARLLHSPWRRDPYPIYRQLRAR
GPLVRSRLGVWAASTYEVCDAVLRDRRFGVRTSDGSYGDPTAAAVGLQLSLLELDPPDHT
RLRKLAAPAFRPRKLENYRQRIEDTAHELLDRALAKGEFDLIRDFATPLPIRVICELLGL
PELGAERLAVHGAALSGALDGIRSIRHLRRMRASTLELNELFGDLIEQRRRQPGEDIVSD
LVTALDQDRLDSTELVQMCDLLLVAGFETTVNLIGNGVLALLERPDQWRLLCDDPDQAVG
VVEETLRWDPPVQTTMRVAHEPVEVAGRLLPRNSAVLPMLGAAGRDPAVHFAPDRFDITR
GTRGDHLAFSSGIHYCLGAPLARLESEIAFRCLATRVPELRRSGALVRRPTSVIHGLSAL
PVAASKATAGGRR

CYP107AW1 Salinispora tropica (marine actinomycete)

MESVTSTSAPPPVPYIADPYPALARIRANGPVSILHSDEGIPMWVIARYRNVRAALADPR
FGQDARRAQTLADNRVAGVTLGGDVIHMLNSDPPDHTRLRHLVQGAFTARRVAAMRPLVE
RITTSLLDGVGGRQTVDLVQDFAFPLPMLVICELLGFPAEERDAYRSWSTAILTHNDDPA
AFATALRDMTDYIEVQLRHRRARPGEDLLTELLAARDAGQLTDDEIVGMVFLLLIGGHET
TVNLLGTATLALVRNPDQHRWLLANPHALSEAIDEFLRYESPVAMATLRFTTAPVTVDDV
VIPAGELVLVSLGGANRDPDRFPDADRLILDRRDTGHLAFGHGLHRCLGAFLGKLEGEVA
LGALLGRYPGLTLAAEVRQLRWRDTIMLRGLESLPVSLHG

CYP107AX1 Salinispora tropica (marine actinomycete)

MTSRPTAVFDQCLLRDPHSRYNALRDQAPVHHVLTPDGAPAWLVTRYNDVRAAFTDPRLS
VDKRFSGTDGEHGSSLPPELDAHLLNRDPPDHTRLRRLAAAACTPRRVADLHPAVERIVS
TLLDGLAGHDRAELIGSLASPLPLQVMHELLGLPTQANIDFRTWTNTLLSADANQPAQSR
AAMANMRRFLIEQLAHKRAQPGDDLLTGLLAAREDDDRLTDDELVAMVFLLMFAGYDNTA
ALIGTVTHALLTNAELHEAVRGGSLALDELIDEVLRWNPAFPLAVRRFAREPITIAGQTI
PAGDRIWLCLASANRDPAQFTQPDELGIIGLRRSHLSFGHGIHYCLGAPLARLQTTIAVT
SLLNRFPEMRLAVPAHDIRWRESFRLRGLIALPVYL

CYP107AY1 Salinispora tropica (marine actinomycete)

MSQDPTMRAELAPIPRSGARLGQEYDQLRNAGDVHQVLLPDSSLAWLVTNPKLVSRALTD
PRLALNRRHSRGSWSGFALPPALDANLLNLDAPDHTRLRRLVGPAFSPQRVSALRPRIRR
TAEHLLDTLVATSGPVDLVTGYCTPLSVQVIADLMGVPEAGRADLRTWTDTMLTSYPPDR
DAIRQAVVELHGYVVDLIDTKRQQPGDDLLSALVTIEQDGDRLTRDELTSLAFLILFAGY
ENTANLIASTVLRLLDHGGLRGVQLPEAIEETLRLEPPAPAAVRRFPTEEMTIGGATIPA
GDIVLLSIAAATRGTAGNAARLAFGNGPHFCLGAALARVEAEEALTVLARRLPDLALALP
VAQVRWRPTFRTHGPAELLVTW

CYP107AZ1 Roseiflexus sp. RS-1, complete genome.

MHHPTEPPPELWSAAAISDPYPIYDRLRAEQPIRWTGGDWQIFR
YADAQALLRDPRLGADRLQVDPQWLIASGLEPLFKTRDSMMLFADPPDHTRLRTLVHR
AFTPRVVESYRPLVQRIVDQLLDAAAARGAIELIGEFAYPLPVTVIAHMLGVPVNMHD
QFRRWSDSLAAFIGGTTRPEADVLPAALKAVLEMTDFFLALVAERRRAPRDDLLSALA
QAEDGGDRLSEQELVANSILLLLAGHETTTNLIGNGMLALMRHPDQFALLRDHPELTP
SAIEELLRYDSPVQVTSRRALTDIEFQGHRIEEGQAVTVFIGAANRDPAQYQDPARLD
VTRGDVRHLSFGHGPHYCLGAPLARLEGQVAISALVRRFPHMRTLDEQVVWRDNFALR
GLQSLHIELE

CYP107BA1 Roseiflexus sp. RS-1, complete genome.

4472327  MTPTIVARLASPEFLADPYPVYRQLIEQTPVFWLPHANAPGGMWCIARYDDIAFVLREAPIFKDT  4472133
4472132  SRIAPPDTLTPLDRAMLQRDPPDHTRLRRLASHAFTPRRVHDLMPRIEQI  4471983
4471982  SLDLIERIGARGEADFIADYA  4471920
4471920  PLPIIVIAELLGVPFEDHEQFSTWSDQIMAGSDSVLGGEEAARQSHQAMASLVDYFTTLI  4471741
4471740  RQRRHSPRDDLISALIAAHDAGDSLSEDELLGMCVLLLIAGHETTVNLIGNGLLTLLRH  4471564
4471563  PDQLNLLRRQSEYLTSAIEEMLRYESPVQRSTPRFAAEPFVIGGEQIEAGQQISLMFGAA  4471384
4471383  NRDPAHFSDPDRFDITRQPNPHLGFGMGIHYCLGAPLARIEARVAFTHILERLPAIRLAT  4471204
4471203  DTPAWKPVTWLRGLKSLPVLV*  4471138

CYP107BB1 PlaO2 [Streptomyces sp. Tu6071].

ABB69746
1 MDRVLDFLSS ADSAGELQPR LVELSRQETL PRVLLADGQE AWLVTRNEDV RTVLSDRSFT
61 RDVMGERARQ AGETPDGARS VNMDGRPHNE LRALVSKAFT VRRIEAMRPR IQAWTDELID
121 AMEETGPPAD LVAHLAVPLP ALAICELLGF PVEDRQVLSG WCERITRLGE GGPDQRAWQE
181 LSAYIARRVP VERAAARGGL APETSILTRL VHAHDSEDAL SMEELLSLTV VVLAGGLETT
241 QTAIGAGMVR LFRNPAQLDK VRADPDLVVP AVEEILRYQP VIDVNRVQVA TRTVRLGGQE
301 IRAGDLVQVS VNAANRDETV FPDSERCDVT RGPNPHLAFG YGAHHCLGAA LARLELKTAF
361 STLLRRLPDL RPAVPLESLG WRGGHVTLGL EELPVAW

CYP107BC1 PlaO5 [Streptomyces sp. Tu6071].

ABB69764
1 MTESLETTSP DPTRSGNSDT GATPGYTVPK QVNDMWREKP VRRFSMRDGR EAWLVTGRAE
61 VRTVLADPRF SRVEARRLDA VMSPAVIFTR PGILDMDPPE HTRLRRLVAG EFSARRMRAL
121 RPRIQQIADE LIGTMKAAGP PADLAEGLSY PLPIAVICEI LGVPYADRER FRAWADRVSA
181 PGTQPQEAMA ALRSLFDYMG GLVDDKHAHP DGSLLHGLVT ARDEQGRLDN EELVTLGCGL
241 LLAGYETTAT MLGKGLLALL DNPDQLAVVR SDPRAVPAAV SEVLRHVTPG VDPHTGLIRA
301 TTADVELGGT VIPAHSVVVA CNTAANFDPA TFRDPDRFDV TRENAAAHLT FGHGMHRCVG
361 AQLAQIELEA AFAALFPAIP GLRLAVPADE ITYTQSTLIR GLRSLPVLW

CYP107BD1 Frankia alni ACN14a

MAETGGFAEVGGVAQTGGAREIFDPRWRSDPYPLYRTLRESARCHWLSPARIGVLTRHADCVAVLQDSAW
GHVPMETSAFRPVTDQDEGLRSMLRANPPTHTRLRRLVSRAFTPARIARFRPMAEALAGELLAAAVDRGE
VDLVEAFTRPLPLRVICSLLGVPAHDEKVFSGWASALTRGLDPDQVLDPVERAQRTEATRAFADYFTALI
ARRRAEPADDLLSDLIAVQDQGDRLGADELLEICVLLLVAGYDTTVNLVANAVLALARDPGQYAALQANR
TLVPAAIEETLRHDPPVQWTGRTALTDTDLAGQAFRAGDGIILVAGAAHRDPAAFPDPDRFDLTRYASAS
APAARHLGFGHGLHYCLGAPLARLEAETMLTALLDRVARLEIVAEPTYRPHLAVRGVDALQIRLHPAG

CYP107BD2 Frankia sp. CcI3

MDADSPSGAAAVGTPPAFGAFDPARRHDPYPSYHALREADPFYRLPLGAQQVTLLTRYQDCMHVLQDAAW
GRGEGGTNAWRSANSFDGGLRSLLGVNPPDHTRLRGLVSKAFTPRVISGLRPQITVLVESLLDAALAAGE
VDLIDAFARPLPLRIICDLLGVPVRDEETFRAWGTALTRGLDPDYLLTPDELALRGKATVEFDAYFTDLI
AARRARPTDDLLGLLVAVREQGDSLTEAELLELCALLLVAGYETTINLIGNAVLALLRDTDQLTALRADP
DLAPALVDETLRHDPPVQFVGRLALRGTEVAGHSFAAGEVGVIMLAAAGRDPRTFAEPDRFDIRRYAGPT
PAPRHLGFGLGIHYCLGAPLARLEAEIALQALVRRAGSLTPASDPPSYRPHLAVRGLETLPIRLSP

CYP107BE1 Frankia alni ACN14a

MATVPASRSASERRSPLLAAFDAARQVDPYSTYRAIREADPLAGHDLAGHRVTLVTRHGDTAAVLQDPAF
GHGYKENISPFRPDGDADDGLESLLRSDPPDHTRLRRLVSRTFTPGTLVELAPDITSFVAGLLDAALEAG
EIDAIRALARPVPTRMICRLLGVPAADEKIFGEWSETLIRGIDPDFLLTPDEITERRRAARELDAYFRDL
IARVRVRPGTDLVSQLVAIHLGEDALTESEVLALCAVLLVAGHETTVNLIGGGVLALVQHPDQLALLRAD
PGLIPAAVEEMLRHDSPVQFIPRTALRDTEVGGRQFRRGEGALLLVGSANRDPDAFDEPDRFLVARYAGS
TPAARHFAFGTGVHYCLGAPLARMEAEIIFRLLLERTSELALIGSTPTYRNQSIIRGLQTLPLRLAA

CYP107BE2 Frankia sp. EAN1pec

MTTVGGMDTSEGGTSAIIAAVTATRLADPYPRYREIREVGAFIPGEIADRTVTLVTRLAEASAVLAHPAV
GHGYTDGINYRTGMDDGLGSLLRADPPDHTRLRRLVGRAFTPAVIEALAPEVTSLANVLLDEAIERGEID
AVAAFARPLPLRLISRLLGVPAADEEEFGGWADALTLGLDPHYLLTDEAKAACNRAAVEFDAYFLDLIAR
RRKEPRDDLLSRLVAIHDRGDMLAERELLELCTLLLVAGYETTANLISGGILALTRNPGQLAALRADPAL
VGPAVEEMLRFDPPVQFIARTVLADAEIGGRPFARGDGAIMMIGAANRDPEAFDEPDRFLVARHTRSDRT
RRHLGLGVGIHYCLGAPLARLEAEIAFRALFSRTSSFALAEDTVAYREQIVVRGLKRLPLHLSA

CYP107BF1 Frankia sp. EAN1pec

MSAAPQVVFDAFAPVYRSNPYPRYALVRESTALYPINPQIAMATRYEECSAVLTDALWGHGYEDGINPFR
PGVDPDDVPGSMLRMDPPDHTRMRGLVKRAFVPRHTEGLRPRVEGLVNELIDTAIEAGEVDLMEALARPL
PLTVIGDMLGIPPEDYTAVKKWSLEIVRGTDPDILQSPESLARRPEAMREFEAYFAGLIAQRRKDPRDDL
LSDLCAAQERDSVLSDREMLGLSVGLLIGGYETVSDLIGKGLVALLRNPDQVALWRSNPELAPYAVDELL
RYEPPVQFTHRVALEERELAGRAFARGEGVVVLIAAANRDPAVYSDPERLDITRFAGRSPAPRHLSLSEG
IHYCLGAHLGRLQTQIAVDTLLLRAPGLSLTDDEPVWRDTVAIHGLDTLPIRLRD

CYP107BG1 Frankia alni ACN14a

MFPVPQVRGTEGAYEGAGFMTTAEIDGDRVDAHRVVDAHDVFDTAHRIDPYPRYRRLRQAGSPTPVRLGD
AEVTLMSRFSDCAAVLQSQAWGHGNVDRLSPFWDQQASLPGSFIRMDPPDHRRLRTLVNKAFSARMVADL
TPMITSLVDTLVDRALAAGGLDVISGLSAPLAQAMVGQRLLGVPAADAEMLRSWELAIARGTDPDALLSA
EDAARRDSAGANVVAYLQDLVARRKAHPEDDLLSRLVAVEESGEVLTAAEVLGICVLLLVAGMETSINLV
GNGILALLAHPDQLALLRARPELAPSAVEEILRYDTPTQFTMRVALTDTTVGERRFRRGDGAIVLMGSAG
RDTDVFDGGERLDVTRYAEPGRSPRHLGFSLGLHYCLGAPLARLEATTAIRTLVERAPALSLATDELSYQ
PSLIHRGLSSLPVDLSPAAA

CYP107BG2 Frankia sp. EAN1pec

MVAAEVTAGVAAESAPVEFTAFHPTHKADPYAVYQRVREARPLCPFMLGDIPVTVLTRYADCEAVLQSDD
WVHGYDAGISPFRDGAASAPRSFLRMDPPDHTRLRGLVNKAFTPRIVNQMAPGIQALADRLVDGALATGS
IDVIGEYAALIASATLGHLLGVPDDVGASLRGWALAIARGTDPDNLLTEAELVARRQATQDFQAYFEELI
AQRRANPTDDLISRMAAARDRDDALSELELLGVSSLLVVAGMETSINYVGSAVLSLLRHPDQLALLRARP
ELLPSAVEEVLRYDPPTQFTMRTACRRTELAGHTFARGDGVLLVSAAAGRDPAAFTDPDRFDITRYHGPR
PARRHLGFSVGIHFCLGAPLARIEAAAAIGALVRRTTTLELAVDEAELVYLPSLIHRALATLPVRVR

CYP107BH1 Frankia alni ACN14a

MPNRPPPLQEPAVDLGTDTSSVLAAGPATALTPPAALTVDQAALNIFDPAWHHDTFPNYQVLREAGPFAP
GPLGLRLVTRYREVEAILADSAWSHAEEGAIMHPDSDGSDLPTSFLWMEPPDHTRIRRLVGKAFSARRIE
ALRARVTEVAGGLVDAAIAAGEVDLVEAIAYPLPLTMIAELMGVPVADHAAVRSMSFGLARGLDPDVLLS
QAEIDLRRESAAAFREYFTDLVARRRADPADDLVSALALAEAEGDRLTADEMLSTLVVLLVAGHETTVSL
ISSTFLMLMRHPDQYAALRARPDLAAPAVDELMRYCTPSHLTTRVATRDVEVLGEQFAAGDGVIILLASA
NRDAGRYADPERLDLARYAGGAAVPRHLAFGRGHHYCIGAPMVRLEMELLLRTLARRAPRLTPLVDPPPY
RPNLVVRGIAELPVRIDG

CYP107BH2 Frankia sp. EAN1pec

MTGPATSTPHAVAGAPAVPDAEAVLAQAVIESFDPAWRHDPYPAYGTLRRAGTFLPGPLAGTMLVPGHAE
CAAILADPVWSHAEESELLHPDSDVELPGSFLWMEPPDHTRLRGLVSRAFTPRTIEATRPLARRVVDGLI
DDALAAGELDLIEGLAYPLPLTMICELLGVPISEHPAVRRMSAGIARGLDPDVLLSPAELAARTAAVEEF
REFFGALVTARRADPRDDLISALAQVHAEGDRLTTTELLGTLLILVVAGHETTVNLIGNGVLALLRDPAQ
LDALRRDPGLALPAVEEILRFDAPAQVTTRTARAEVTVAGRTFTPGEAVICMLGSANRDPRAFDRPDEFL
VDRYAGGARVSRHLALGMGLHYCLGAPLVRLEVGEVLRGIATRLTGMTLLADPPPYRPNIVVRGMSSLPV
RVTGRPG

CYP107BH3P Frankia sp. CcI3 YP_481037.1 ABD11308.1

MDSAAPSLGAPDWPARSDPEMEPPGHTRLRGLVSKAFTPRTIEGMRPWAEQVVDDLLSRLIQR
GLTSLPLSLTPGGVA

CYP107BJ1 Frankia alni ACN14a

MVTVQPASSEAYVPPNESSPEQTGARLLAKLFDPANRHDPYSIYTELRAAGPLHTGPFDLKLANRYADCA
AVLGSQEWGHDREPHQLHPTIPAEAFPASFLWMEPPDHTRLRGLVTKAFTARTVAALRPRIAALVDELLD
NALRQGEFDLIATIAYPLPLTVVCEILGVPAEDHPLVQVWSQALARAFDPDVLMTPEALAERNRAIPEFL
SYFRALVSRRRREATGDDLITQLAAVEEQGDRLTEEELLGTCVTLLIAGHETTVNLVGNGMMALIRHPDQ
VALLRERPELIGPAVDELLRYDSPIHMNTRAAKRELVVGGEVFAPGEGIVALIACANRDPLVYDDPERLD
VTRFHTSKPIARHLSFSLGHHYCLGAPLALLEMELLLAGVLDRVADMELLTDTPPYKPNMLIRGLAELPT
RFHAA

CYP107BJ2 Frankia sp. CcI3

MAVTTDSVFAGADAGTGVAADHGKPLPDQAPDLLAALFDPANRPNPYPLYARLRAAGRLHETPFGLRVAT
RHDDCVAVLSNQSWGHDQEAHQLHPTLPAEEFPATFLWMEPPDHTRLRGLVSKAFTPGRVADLRPRITAL
VDDLLDTALRAGEFDLIETIAYPLPLTIICEILGVPAADHGIIQIWSQALARAFDPDVLMSPEALAERND
AIPEFLAYFRALVARSRRSGGDDLLSALAAVEEQGDRLTEDELLGTCVTLLIAGHETTVNLVGNGALALL
RNPDQTALLRDEPDLIRPAVDELLRYDSPIHLNTRAATREMTVGGRTFSPGEGVVALIACANRDPEAFDD
PDRLDVRRYVAGSGASRHLSFSLGHHYCLGAPLALLEMEIFLAGFLHRVRSAELLVDSPPYKSNLLIRGL
AELPVRFRG

CYP107BJ3 Frankia sp. EAN1pec

MTTSTVVPTAGTGSSGPAGEESTALLAELFDPATRPDPYPVYSRLREAGALHATPFGLPVATRHADCVAV
LANQDWGHDLEAHQMHPTLPAESFPTTFLWMEPPDHTRLRGLVSKGFTPRSVQLLRPRITALVDELLDNA
LAAGEFDLVETIAYPLPLTVICEILGVPAADHPAVQVWSQALARAFDPDALMSPEALAERNRAIPEFLEY
FGALVERHRREPGDNLISALAQVEEAGDRLTADELLGTCVTLIIAGHETTVNLVGNGMLALLRNPDQLAL
LRAEPELIPAAVEELLRYDSPIHLNTRAAKRELEVAGRVFAPGEGVVALIACANRDPRAYPDPDRLDVRR
FTSSAGGPPARHLSFSLGHHYCLGAPLALLEMELLLAAFVRRVSHAEITDNNPPYKPNLLIRGLAELPVR
FRG

CYP107BK1 SBI_9749 Streptomyces bingchengensis

42% to CYP107AN1 Bradyrhizobium japonicum USDA 110
MEMSIIFDPRDPSVRTDPYPIYRRLRETDPIHQSHFGYWILSRYADVDAV
LRAPGASSEFYRDRTWANRRGGPDSPLVQSVRKWMLMLDGPAHRRIRGAI
SKVFTRASVERLRPRIAAETARLLDAAGEGKTDLIHSLALPLPVTVTCEL
LGLPGSDRDQCRRWTEQISRVIDPSITAEDAVEMNAAEVEFREYVADHLK
ERRSAPRDDILSLLLHAEVDGGQLTEEEIIANVQFLFVAGHETTVNLIGN
GLLALLRHPDQLRMLRDNPEIITDSIDEITRYDPPVQIVSRLLTEDVPLT
DVTLPAGAKVMLLFGAAGRDPERYPDPDRLDLTRTGVKTLAFSGGPHYCI
GAALGKLETSMMLTELLRRYSTIELTGDDLVWRPNVSFRGLQELPLQLVR

CYP107BM1 Streptomyces hygroscopicus ATCC 53653 ACEX01000414.1 3915-5168 (+) strand

MSENAMSENATHLTPEQVEDPVRGYADLRTRDELPH
AVLPGLTTPVRLVTRYADVKAALTEPRLIRDRTRIPGDADEAQASDAQDELLEAASAGLP
AEYVKYFAGHLALFDGEEHAHRRAPLTRAFTARRIAALRTFVERTADALVAEAEANGGTD
LLGAFAYPLATQVICELIGVEERDRDQVCSWMRDFAFGDGSRAGEALVALVEYAKELIAR
RRAEPTEDLISALLDGDQLTEDDLIGIVFLLINTGITPPALFLAHAALALLDHPEQAARL
HAAPELLPRAVPELLRYVSIVRIGATLYATEDVDFAGTALRRGESVTVALLAADHDPEEF
GDGAGQLDVGREFGRGDGHLAFGHGAHYCIGAALGRLVTSVVLDRLFVRHDGLRLAVPRA
ELEFGHWPGDGFHLLRLPVRL*

CYP107BM2 Streptomyces sp. C strain C ACEW01000053.1 15059-16303 (+) strand

MNETVHHLSPDRLQDPATGYAGLGDGDGLPRVVLPGLRTPV
RLVTRYADVKAALTEPRLIRDRTKVPGATDGPDAQDELLAPLGDLPPEYARYVSAHLAFL
DGAEHARLRTPLTRAFTARRVASLRPFVEESAARLIGELAGRKEADLLNEFAYPLATSVI
CELVGVDEADRARVCDWIRDFAYGDGSRMGDGLAGVVEYVKALIARRTAAPADDLISALL
GGAREGGAGALDEEEITAMVFLLINTGITPPALFLAHAVLALLDHPGQLDRLRAEPELLG
RAVPELLRHVTLLRIGATLYATEDFVFAGTGLRRGDSVTVALLAANHDPAVYGEASARLD
VTREAARGRGHLAFGHGAHHCIGAALGSLVTGVVFERLLVRRPVPELAVARGELEFGHWP
GDGFHLLRLPVRL*

CYP107BM3 = old CYP107BL1 SBI_9870 Streptomyces bingchengensis

51% to CYP107L1 Streptomyces venezuelae
MTQQPIVLPYGDPAFVADPFPFYRMLCQGQPGEDGPVRRAVIAGGLEVWL
VTPFEECLAALSDPRLSSDVRLATDPRLMRQLPVAERESVLGNMLRADPP
DHTRLRRLVSRAFTARRVAELRPHVQEIADRLLDAVVPTGRADLIEDFAL
PLPVTVISELLGVPTDDRRAFQRWVDHLLPWGAEPQDPAVVERAWRQMRA
YLTGLLATKRVRPGEDLLSALIEARDEQRRLTEDELVSMAFLLLAAGYIT
TVNLIGGGIAALLAHPDQLRTLRDDPALLPDAIEELLRYDGPVNPGVARF
ASEDVSIAGVDIPRGATVLVGSALADRDPERFPDPDRLDISRGDSAHLAF
GHGIHYCLGASLARMEGEVAIGTVLRRLPQLALSVAPGELRWRPTGLRGP
ERLPVTFTPGASLAAVPS

CYP107BN1P Frankia sp. CcI3 YP_483188.1 ABD13459.1 40% to CAJ61641 same as ABD13459 39% to CYP107AH1 Streptomyces peucetius

MQQCLGEAMRSLHDCAVEMVLREREEPGNGALGALTVVRDEDGTGFSDEELVSTVLLTAIAGYESTVVQI
GNGFLAMFRHPEQMEHLKRGRTDIAAAVEEILRYAQSSTGFAGMTYAMADVELGSVTVPAGATVFVSLDS
AARDEAHVDSPQRFELSRGSARHHVTFGSGHHYRA

CYP107BP1P Frankia sp. EAN1pec YP_001505775.1 ABW10869.1 41% to CYP107AT1 Saccharopolyspora erythraea no heme signature MPSRDIAAAGYMRSPRAKSTESREILMSVDETTEGCVTDANGNLIAYGATSCMVSQLEPSTDVNVSPPAA

APHTTFDEFHA
FDVFDPEHWPNPYPRYAMARKARPLIRTPLGVHLVTRYQDCATILQDNNWSHAHKAELF
HPGVEHVDLPTSFLWMDPPDHTRLRALVSKAFTPRTVANLRPRIEQLVKDLFDAIIEAREVDVISALAYP
LPLTIIAELLGAPAEDHPDLQRWSRALARGFDPEPLLSP
GNVTHAPMPPVSSWPTSADWAPGNGVSGTRR
AGKHALSVVNPVSTRRRLVTAGVEETDDWSGWLRERRHDDIPLSQRENPHERAVRSTTNTAGRTSGRKGG
PRSRRTEPGCRYRSACSCSRCRSCCRRCRTTPTSRAEQQIGVGATRR

CYP107BQ1P Frankia alni ACN14a YP_715801.1 CAJ64277.1 56% to CYP107L3 Streptomyces tubercidicus (N-term lower case only) MTIRTASQEVPMSPTDPIPLYgpqykrdpyplyrrlratgpvhrvrfpsgvigwlvtgyraahealndhr

lgknHALGTSDALSALIDEEGLRHLDLFSLRDILGDLPYDDKRSSVSRRYGPTSEQLRAEVRSDEDTRRL
YQGITRFLVEDTAEFVGSRSALQRECRQRAYGVIGRSRAWGRLVAEHHPRAVRLSIHPQRRGTSKFGIRL
LESSDAWMTPWHATVLRRADGASELMRRADAQRLGRLVTRDGRPSHFQAHAAV

CYP107BR1 Pseudonocardia autotrophica NBRC 12743 AB456955 vdh gene for vitamin D hydroxylase, 50% to CYP107AF1 Streptomyces collinus MALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGP

VWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLV
GRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAED
RDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDG
DRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEF
LRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDA
SGGVFFGHGIHFCLGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLS
RMPVTMGPRSA

CYP107BR2 Geodermatophilus obscurus DSM 43160 CP001867.1 56% to CYP107BR1 MTAVDASVFEGSFWRDPYPAYERLRAQAPVREVALPRGGTTWLVTRYDDVRAAFTDPRLV

KDHRATLPPEVRAQAPRLPGPFGSMMILLDPPDHTRLRRLVSRAFTARRTAELRPRIEAL
AAALLDAVPETEPVDLLAGYAVPLPMAVICELLGVPDTDRDAFGTWSRALVDDQDDVDEQ
QATAGLAQYLYALVETKRRAPDGALISALVEVSEAGDQLSTEEVVAMGVLLLIAGHETTA
NLIGNAVLGVATDAALREHLLADPQRIPAAVEEFLRWDGPVHNAPLRFAAEDVEYSGTTI
PAGSVVTLSVGAANRDPGRFDRPELLDPDRETGGHLAFGHGLHYCLGAPLARLEGEVALR
SLLDRFPDLRLAVPPEELRHRRSVLVHALETLPVVLRPEAAGSASA

CYP107BX1 SGR810 Streptomyces griseus

MHRLFFEEPGPPRPAELPGGDPAWLVSRYADVRQVLSDPRFGRARLYAPEAPALSGVPDLVNNPDLMFNQDGSDHLRLRRTLRRAFTPRAVARWRPWIAATVEGILDRLESRPQPADVVAEFALPLPVAVISRLMGLDESVWDRMRYWSEHAFSDGTHEREQVAAALKEFSAFGAH
LLAERRSTPGEDLVSGLVTAADEEGGVPEAQLVSLVCGLVVGGHDSTMTMLGNALLYLLGERRETWPRLGADEEAAGLLVERLVHLVPLGDDRGSTRHAAEDVEVSGVRIPAGAIVIADCGMANRDPEVFPPATLYDLFAPLEAPTLSFGAGPHYCLGAWLARTELQLALHRLAAR
FPELRLADPVDAVVWRTGTTSRSPRRLGVRW

CYP107BY1 SGR895 Streptomyces griseus

SGR895 putative cytochrome P450 376-aa MW:41055.09
42% to CYP107L2 Streptomyces avermitilis
MTADPYPGYAWLREHDPVCPVGGPHVPGRMWLVTRYDDVRACLADRRLGSRAPVDPDPHPPGLSHLDGPGHARLRRLVAAAFTPAAVARLRDRTARTCAHAVESFAGRGHADLVAEYTREIPVAVMHDLLGVPETERAPAADVLDMWYRAKFRQPRDEASLAELLDYVGELVA
YKRTHPGDDLTTRLIDSDALTGEELEVMVMTLIGAGHITTIQFLGTTVLHLLDHPGHRAALLRGDLDWPRAVNELLRLDSPSHVAEYRYAGEDMTLADARVGEGDVVLLSLAAANRDPDRFPDPGTLDLTRDARPHLAFGHGAHTCLGSHLVRLETEIAVTTLFGRLPDLALDIPGGE
VAWGYAPTFRGPLALPVTFTPSTSR

CYP107BZ1 SGR3274 Streptomyces griseus

MTGTQTLSKYWMLTNEFTQNPYPVLDHVRREGPVRELSFPDGGRAWVVTRYEEAKAALADPRLSRDIHVHYRLMSRRTGRALTPPPEEANHLANLEPPRHTPLRRAISFAFTPRRAEALRPKVERIADDLLDRLGEAPEAELIAGYADPLPVITIAELMGVPADAWPDFLRWSTALRT
HSPTDGSGVLDRNVQELSAYMADLIARKEREPGEDLLSALIHAAPENRLTPTEILSTGFALMTGGNDTTASLVGGVIAALLTHPRERARLLADTGRWGKSMDELIRYVSPISNALQRVTTEPVDVGGVTIPAGEVVVVCVMSTNRDTGQFPGHPDRLDLDRVKPAHLSFGFGIHYCSGA
HLAKVITEVSARRLFERFPAARLAVDPSRLRYQQNVVVRPLEALPVLLRP

CYP107CA1 SGR6789 Streptomyces griseus

MTATGHEIRDYPFGPVDRLDLDPALVEICGEHPVLRVRLPFGGDGWLVTRYADVRAVLSDPRFSRSAAAGDHVPRTVAVAPPPTSIMGMDPPDHTRLRRRVMRAFTVRSIDALRPRIAEIVNDLVDTMTEGDGPADLAAVLTWPLPITVICEMLGVPRADQDRFTEWVDGLLILDDPE
RSADARRQLGDYLAVLIAQRRAEPTDDLLGELAADSGKDPLSEEELVGLGVSLLSAGQEATANQIGNFVYTLLTRPALWRELVADPSIVPRAVEELSRFIPISATAGFTRVATEDLELGGQLIRAGDAVVAELGMANRDSAVFDRPEEIDFHREQIPHVTFGYGIHHCLGAQLARVELRV
VLETLVTRLPGLRLAVPADQLAWRTERLIRGVAALPVRW

CYP107 fragment Streptomyces noursei

63% to CYP107A2 Streptomyces rochei
WTTPTRWSCSAPSLICLPRHGRNTAHRRTSRSHHPGRARRHPDR
DTLIPARSTVFIAGAAANRDPQKFPNPDTFDITRNTQGHLAFGYGVHHCIGRPLAQME
GEVAITALLRRFPHLHLTTPSQNLTWRRSFLRGLTALPVTLN

CYP108A1 Pseudomonas spp.

MDARATIPEHIARTVILPQGYADDEVIYPAFKWLRDEQPLAMAH
IEGYDPMWIATKHADVMQIGKQPGLFSNAEGSEILYDQNNEAFMRSISGGCPHVIDSL
TSMDPPTHTAYRGLTLNWFQPASIRKLEENIRRIAQASVQRLLDFDGECDFMTDCALY
YPLHVVMTALGVPEDDEPLMLKLTQDFFGVHEPDEQAVAAPRQSADEAARRFHETIAT
FYDYFNGFTVDRRSCPKDDVMSLLANSKLDGNYIDDKYINAYYVAIATAGHDTTSSSS
GGAIIGLSRNPEQLALAKSDPALIPRLVDEAVRWTAPVKSFMRTALADTEVRGQNIKR
GDRIMLSYPSANRDEEVFSNPDEFDITRFPNRHLGFGWGAHMCLGQHLAKLEMKIFFE
ELLPKLKSVELSGPPRLVATNFVGGPKNVPIRFTKA

CYP108B1 Mycobacterium smegmatis

MFLTPVKFSPSEVPD
MSTPVINDAARVLAEPRAYADEPRLHAALAELRSQTPVAYVDVPGYYPFW
AITKHADVMAIERDNELFINAPRPMLITKEKDDLAKANLAAGGGIRTLIH
MDDPLHRDIRKIGADWFRPKAMRALKERVDELAKIYVDKLVEKGPECDFV
QEVAVNYPLYVILSLLGLPESDFDRMLKLTQELFGNDDDEMGRGSSAEEL
NAVILDFFNYFTELTADRRANPTEDLASAIANAKLNGEYLNDVDCLSYYV
IVASAGHDTTSAAISGGLLALTENQDQLARLKADMSLMPLATEEIIRWSA
PVKEFMRTATRDTEVRGVPIKEGESVLLSYVSANRDEEIFENADKFDVGR
DPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEFMAT
TFVGGLKHLPIRYSVR

CYP108B2 Mycobacterium smegmatis

MSTPTMDDAAKALADPTAYADDARLHEALARLRAENPVAWVDQAPYRPFW
AITKHADIMAIERANDLWLSAPRPLLATAEADDLGRSQQEMGIGLRTLIH
MDDPHHRKVRAIGADWFRPKAMRELKVRVDELARIYVDKMREIGPECDFV
TDIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGTTVEEQ
MAVLTDFFNYFSALTNSRRENPTDDLASAIANGRVDGELMSDMDTLSYYV
IVASAGHDTTKDAISGGLHALIENPGELARLKADPGLMGTAVEEMIRWST
PVKEFMRTAAEDTEVRGVPIAKGESVYLAYVSGNRDEEVFTDPFRFDVGR
DPNKHLAFGYGVHFCLGAALARMEMNSLFSELLPRLDSIELAGEPELSAT
TFVGGLKHLPIRYSIR

CYP108B3 Mycobacterium smegmatis

MTARTIDDAAKVFAMPSAYTDEAKFHEALTHLRVNAPVSWVDVPPYRPFW
AITRYADIMAIERANDLFTNSPRPVLMTAEEDEQQAAVGISTLIHMDDPQ
HRVIRAIGADWFRPKAMRALKIRVDELAKIHVDKMVAAGGECDFVQEITV
NYPLYVIMSLLGIPEADFPLMLKLTQELFGNKDDEYQRSADEGDSMAALL
EMFQYFTELTASRRANPTDDLASAIANATVNGEPLNDIETVSYYAIVAAA
GHDTTSATISGGMLALLEHPDQLERLRNDPSLMGTATEEMIRWVTPVKAF
MRTAATDTVVRDVPIAAGESLLLAYPSGNRDEEVFTDPFRFDVGRDPNKH
VAFGYGVHFCLGAALARMEINSFFAELIPRLESIELTGSPRHTATTFVGG
LKHLPVRYALR

CYP108B4 Mycobacterium marinum MM3999

MSAPTMDEAA LLADPLAYTD ETRLHAALTR LRAQAPVALV DVPNYRRFWA ITRHADVMDI
ERDNTLFTNW PRPVLATVAG DELQAAAGVR TLIHLDDPQH RVARAIGADW FRPKAMRALK
VRVDELAKNY VDAMMAAGPE CDFVQQIAVN YPLYVIMSLL GLPEADFPRM LKLTQELFGS
DDSEFKRGST SEDQLPALLD MFGYFNAVTT ARREHPTEDL ASAIANARID GEPLSDIDTV
SYYLIVATAG HDTTSATISG GLHALIEHPD QLARLQADPA LIPLATEEMI RWVTPVKQFM
RTASRDTVVR GIPIAAGESV LLSYVSANRD EEVFDQPFRF DIGREPNKHV AFGYGVHFCM
GAALARMEVG SFFTELLPRL KSIELSGDPQ FTATTFVGGL KHLPVSYSLV *

CYP108B4 Mycobacterium ulcerans

MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDI
ERDNTLFTNWPRPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALK
VRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGS
DDSEFKRGSTSEDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGEPLSDIDTV
SYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMSLATEEMIRWVTPVKQFM
RTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYGVHFCM
GAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM

CYP108B5 Mycobacterium avium subsp. paratuberculosis K-10.

MSTTTMDEAA KLLADPMAYT DEQRLHAALT HLRANAPVSW VEVPNYKPFW AITKHADVMD
IERENMLFTN WPRPVLTTAE GDEMQAAAGV RTLIHMDDPQ HRVVRAIGSD WFRPKAMRAL
KVRVDELAKI YVDKMLAAGP ECDFVQEVAV NYPLYVIMSL LGLPEADFPR MLKLTQELFG
SDDSEFKRGS SNEDQLPALL DMFGYFNGVT AARREHPTED LASAIANARV DGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLQRLRDNL DLMPLATEEM IRWVTPVKEF
MRTAAKDTVV RGVPIAAGES VLLSYVSANR DEDVFDEPFR FDVGRDPNKH LAFGYGVHFC
MGAALARMEV NSFFTELLPR LKSIELTGDP ELVATTFVGG LKHLPVRYSL A

CYP108B6 Mycobacterium flavescens PYR-GCK

MSVRVADEAG KVFADPTAYA DEQRLHAAMT HLRANAPVSW VDVEGYNPFW AITKHADIMA
IERDNTVFTN SPRPVLTTAE GDAQHASMGV STLIHMDDPQ HRKVRAIGAD WFRPKAMRAL
KVRVDELAKT FVDQMYDRGG ECDFVQEVAV NFPLYVIMSL LGIPESDFGR MLTYTQELFG
SDDAELQRGT TMEERGLALF DMFTYFNELT ASRRAQPTED LASAIANARI NGEPLSDIDT
VSYYLIVATA GHDTTSATIS GGLQALIENP DQLARLQQAP ELLPLAVEEM IRWVTPVKEF
MRTAQQDTEV RGVPIAAGES VLLSYPSGNR DEDVFTDPFR FDIGRDPNKH VAFGYGVHFC
LGAALARMEI NSFFSELLPR LTSVELAGRP EHIATIFVGG LKHLPIRYSL TR

CYP108B7 Mycobacterium vanbaalenii PYR-1

MSVRIADEAARVFADPSAYADEARLHAAMTHLRANAPVSWVEVPGYNPFWAITKHADIMAVERDNLVFTN
SPRPVLTTAEGDAQHEAMGISTLIHLDDPQHRKVRAIGADWFRPKAMRALKVRVDELAKTFVDQMYERGG
ECDFVQEVAVNFPLYVIMSLLGIPESDFQRMLTYTQELFGNDDAELQRGESMEERGLALFDMFTYFNEIT
AARRARPTEDLASAIANARIDGAPLSDIDTVSYYLIVATAGHDTTSATISGGLQALIENPDQLQRLQQNP
GLMPLAVEEMIRWVTPVKEFMRTAQQDAEVRGVKIAAGESVLLSYPSGNRDEDVFTDPFRFDVGRDPNKH
VAFGYGVHFCLGAALARMEINSFFTELLPRLKSVELAGRPEHIATIFVGGLKHLPIRYSLTR

CYP108B8 Mycobacterium vanbaalenii PYR-1

MSTPTMNQESQEAAKVLADPTAYADDQRLHKALAHLRANDPVAWVDHPPYRPFWAITKHADIMAIERAND
LFLSEPRPVLVTAEADDMARAQLEAGFGLRTLIHMDDPHHRKVRAIGADWFRPKAMRDLKIRVDELAKRY
VDKMRDIGPECDFVTEIAVNFPLYVILSLLGLPEEDFGRMHMLTQEMFGGDDDEYKRGATVEEQMAVLTD
FFNYFGALTASRRANPTDDLASAIANGLVDGELMSDVDTLSYYVIVASAGHDTTKDAISGGLHALVENPG
ELARLQGDLDLMPTAVEEMIRWSTPVKEFMRTAAEDTTVRGVPIAKGESVYLAYVSANRDEDIFDDPFRF
DVGRDPNKHLSFGYGVHFCLGAALARMEINSLFSELLPRLDSIELAGRPELSATTFVGGLKHLPVRYSLR

CYP108B9 Mycobacterium vanbaalenii PYR-1

MSTPVIDEAASDAARVLADPKAYTDEARLHAALAHLRAHAPVSYVDVPDYRPFWAVTKHSDIMAIERDNE
LWINEPRPLLTTAATDDLSQANLAAGGGIRTLIHMDDPLHRDIRKIGADWFRPKAMRDLKTRVDELAKIY
VDKMVEKGPECDFVQEVAVNFPLYVILSLLGLPESDFGRMLKLTQEMFGGDDDELTRGKSPEELHEVITD
FFRYFTALTAERRANPTEDLASAIANAKLDGEYLNDIDCLSYYVIVASAGHDTTSAAISGGMLALIENQD
QLARLKAQPELMGTAVEEIIRWTTPVKEFMRTATADTEVRGVPIREGESVLLSYVSANRDEDIFDEPAKF
DVGRDPNKHLSFGYGVHFCLGAALARMEINSFFTELIPRLESIELAGDPEYIATIFVGGLKHLPIRYSVR

CYP108B10 Frankia sp. EAN1pec

MDIEAAATVFTDPRAYADNERFHTATALLRRESPIHRIEHPNFHPFWAVTKHEDVMAISRASDIWINEPR
PALGPKPKDAERENIPIRSLVQMDAPDHPVYRHVSADWFKPAGVRRLRDRIAELAKRFVDRMADQGGECD
FFTDIVSHYPLYVILSLLGLPEEDFPRMLRLTQELFGADDEDLARDQDKQAQRAPLVDFFNYFQALIQDR
RENPTDDLGSVIANATIQGEQIGKLEAAGYYTLIATAGHDTTSAALAGGLHALLESPGQWQRLVDDPRMV
ATGVDEMIRWVSPVKHFMRTAREDTVVRGVALAAGESVLLSYPSANRDEDVFENPDTFDVGRSPNRHVAF
GFGAHYCLGTHLARLEGQALYAELVPRVRSIELAGTPEYMEALFVGGPKRLPIRYTMA

CYP108B11 Frankia sp. EAN1pec

MGFRSRALVIDNIPNRRASALGSLPLGSPWRGTHEGGPGMDIAEAATVFTDPTAYADNQRFHTATALLRR
AAPVQRVEHEDFESFYAITKHDDVMTISRGSDIWRNAPRPALGPKPKDGRAAEDAPVRTLIQMDAPDHPV
YRHISAEWFKPLGVRRLAGRIAELAKRYVDTMADFGGACDFFADVACHYPLYVILSLLGLPEDDFPRMLK
LTQELFGANDPDMARGSGDEQALMAALLDFFTYFQALTADRRANPTDDLASVIANATIDGEPIGELEAIG
YYVLIATAGHDTTSSALAGGMHALLQYPDQWRRLSENPGLVPTAFDEMIRWVTPVKQFMRTAARDTEIRG
VPIAAGESVLLSYPSANRDEDVFDNPDTFDVGRTPNRHVAFGFGAHYCLGTHLARLEGQALYAELVPRLR
SIDLAGTPEYMETLFVGGPKRLPIRYTMT

CYP108B12P Frankia sp. EAN1pec YP_001509055.1 ABW14149.1 67% to CYP108B7 Mycobacterium vanbaalenii PYR-1

MDLDEAGSVFTDPTAYADEKRWHTATALLRRHSPVHRVESAGFAPFWAVTRHEDVFTDPEAFDVGRTPNK
HVGFGFGAHYCLGTHLARLEGRALYTELVPRLREVELAGTPEYMQTLFVGGPKHLPIRYTIT

CYP108C1 Saccharopolyspora spinosa strain NRRL 18395

VNIKLMGAGRTLADPAAYANDDRIHKALALLRREAPVHWVEAPGYRPFWAITRHADVMEIERQPDLFRNAPRPILV
PDAMEKRTAAQGTNFRTLVSMDGAEHRQVRAIGTDWFGPGALRHLETRVTELARQYVDRMLEFDGECDFVTDIAVH
YPLDVILSLLGLPRSDFPRVLSLAKELLGNADQEINGGRGAEGFVAVQQELLTYFNELTAARRATPTTDLASAIAN
ARLDGALLSEFDAASYYILIATAGHDTTSASIAGGLQALIENPQQLRQLQDDLTLLPTAVDEMIRWVTPIKCFLRT
ATEDYVLRGTTIRKGDSVLLSYPSANRDEDLFEEPFRFDIRRTPNRHLAFGFGVHYCLGAALAKMEARAFFAELLP
RLDSVQLAGKAELFATNFIGGLKHLPIRYKLRPSV

CYP108D1 Novosphingobium aromaticivorans

MTNTSRLTKRRRPRRSDGKREGFMDSIPMVPAEVGRAVIDPKSY
GTWEPLLDRFDALRAEAPVAKVVAPDDEHEPFWLVSSFDGVMKASKDNATFLNNPKST
VFTLRVGEMMAKAITGGSPHLVESLVQMDAPKHPKLRRLTQDWFMPKNLARLDGEIRK
IANEAIDRMLGAGEEGDFMALVAAPYPLHVVMQILGVPPEDEPKMLFLTQQMFGGQDE
DMNKSGLKDLPPEQISQIVAGAVAEFERYFAGLAAERRRNPTDDVATVIANAVVDGEP
MSDRDTAGYYIITASAGHDTTSASSAGAALALARDPDLFARVKADRNLLPGIVEEAIR
WTTPVQHFMRTAATDTELCGQKIAAGDWLMLNYVAANHDPAQFPEPRKFDPTRPANRH
LAFGAGSHQCLGLHLARLEMRVLLDVLLDRVDSLELAGEPKRVNSTFVGGFKSLPMRW
KAA

CYP108E1 Ralstonia metallidurans

MTIASDFDTELASHEIYSDPERMHEMFETLRREDPVHWTTAPGH
PPFWAVTKQADVIEVGKHPDVFIASPKSFLMNDVEQRVRIEETAATGGKLVRTMIHMD
DPDHKKYRGLTQSYFMPANIKRLESVIQERARALVGRLIEKGTSEFCSEIAVWYPLQI
VMTLLDVPESEHPYLLKLTQQFLAPKDPTLRRDGPDERGKGAVAKEYFAYFGKMLAER
RAAPLKEDLGSLIAHATVDGEPLPLMEAVSYYVILATAGHDTTSSSMCSGLYYLLTQP
GELDRLRARPELMPSAIEEMFRHGSPVKHFVRTATRDFELRGKKIQAGDEVALMYHSA
SFDEEVFDEPRSFRIDRGPNKHVAFGFGIHACLGQNLARASMRTFFTELLARTESIEV
VGKAEFIASNQVGGMKTLNIRVTPSKQSTTDRIEVAA

CYP108F1X = 108B4 Mycobacterium marinum MM3999

MSAPTMDEAA LLADPLAYTD ETRLHAALTR LRAQAPVALV DVPNYRRFWA ITRHADVMDI
ERDNTLFTNW PRPVLATVAG DELQAAAGVR TLIHLDDPQH RVARAIGADW FRPKAMRALK
VRVDELAKNY VDAMMAAGPE CDFVQQIAVN YPLYVIMSLL GLPEADFPRM LKLTQELFGS
DDSEFKRGST SEDQLPALLD MFGYFNAVTT ARREHPTEDL ASAIANARID GEPLSDIDTV
SYYLIVATAG HDTTSATISG GLHALIEHPD QLARLQADPA LIPLATEEMI RWVTPVKQFM
RTASRDTVVR GIPIAAGESV LLSYVSANRD EEVFDQPFRF DIGREPNKHV AFGYGVHFCM
GAALARMEVG SFFTELLPRL KSIELSGDPQ FTATTFVGGL KHLPVSYSLV *

CYP108F1X = 108B4 Mycobacterium ulcerans

MSAPTMDEAALLADPLAYTDETRLHAALTRLRAQAPVALVDVPNYRRFWAITRHADVMDI
ERDNTLFTNWPRPVLATVAGDELQAAAGVRTLIHLDDPQHRVARAIGADWFRPKAMRALK
VRVDELAKNYVDAMMAAGPECDFVQQIAVNYPLYVIMSLLGLPEADFPRMLKLTQELFGS
DDSEFKRGSTSEDQLPALLDMFGYFNAVTTARRAHPTADLASAIANARIDGEPLSDIDTV
SYYLIVATAGHDTTSATISGGLHALIEHPDQLARLQADPALMSLATEEMIRWVTPVKQFM
RTASSDTVVRGIPIAAGESVLLSYVSANRDEEVFDQPFRFDIGREPNKHVAFGYGVHFCM
GAALARMEVASFFTELLPRLKSIELSGDPQFTATTFVGGLKRLPVSYSLM

CYP108G1 Caulobacter crescentus CB15

1 MTISTDIANT IIDPKAYADG DRIDQAFAHL RREAPLAVAQ PDGFDPFWVV TRHADILEVE
61 RQNELFHNGD RATVVTTIEP DKKVREMMGG SPHLVRSLVQ MDNPDHFAYR KITQGALLPQ
121 NLRALEARIR EIARGFVDRM AEHGDRCDFA RDVAFLYPLH VIMEVLGVPE SDEPRMLKLT
181 QELFGNADPD LNRTGKSVTD VGEGVDSIQS VVMDFMMYFN AITEDRRANP RDDLATLIAN
241 GKINGEPMGH LEAMSYYIIA ATAGHDTTSS TTAGALWALA ENPDQFAKVK ADPSLIPGLI
301 EESIRWVTPV KHFMRTATAD AELGGQKIAK GDWIMLSYPS GNRDEAVFED PFTFRVDRTP
361 NKHVAFGYGA HICLGQHLAR MEMRVLWEEL FARLDHVELD GAPTRMVANF VCGPKSVPIR
421 FKMH

CYP108G2 Ectocarpus bacterium, 67% to CYP108G1 Caulobacter crescentus AE005918

159023 MIDPNIPDDIAITVVDPRSYADGNAIDEAFAKLRKDTPLGVAGPQGFEPFWVVTKHKD
IVEVERNNEVFHNGDKSTTLVDANTDTA 158766
158765 VREMMGGSPHLIRSLVQMDNPDHKNYRGITAANFMPQELKALEVQVRKIAKSFVDHMEEL 158586
158585 GRKNDGRCDFAKDVAFLYPLHVIMELLGVPQSDEPKMLKLTQELFGAADPELNRTGKE 158412
158411 RDDPKEALAALSGTVAEFVEYFTAVTEDRRKTPRADIASVIANGKVNGEAIGIFEAMGYY 158232
158231 IIVATAGHDTTSGTTAGTMWELAKDRQKFLQVKNDPKLIPLLVEESIRWVTPVKHFMRSA 158052
158051 TQDTVLGGQEIKKGDWMMLCYQSGNRDEDVFDDPFEFKVNRQPNRHIAFGHGAHVCLGQH 157872
157871 LARMEMRALWEELLPRLDSVELDGEPTRMLANFVCGPKSVPIKFKMS* 157728

CYP108G3 ABS63163.1 Parvibaculum lavamentivorans DS-1

CDS complement(1684831..1686087) locus_tag=”Plav_1544″
56% to CYP108G1 Caulobacter crescentus
MTDKTIDNAIVNPKTYAHVDEFHRLFTQLRKEEPVRWTEPDGFRPFWTVSKHADIMEVERQNDKFLNDPR
LTLQTIEVEEEVKKFTGGNSKLIRSLVDMDNPDHRNYRGLTQAWFMPPNLKAISARVEALAEKYIDRLEA
KGGECDFVSDVAVWYPLRVIMTVLGVPAEDEPIMLKLTQELFGSTDPDMKRPDATETVNTVTEFFNYFTA
MTEDRRKNPKDDVASVIANATIDGEPIGHLEAISYYIIVATAGHDTTSSTAAGGLLALMQNPEEFAKLKA
NPEGLLGGAIDEMIRWTTPVKHFFRTAAVDYELRGQKIKAGDNLLMCYWSANRDEEAFDDPFSFKIERSP
NKHLAFGYGAHLCLGQHLAKMEIRALYKELLARLDHIELAGDPAWVEASFVSGLKRLPIRYSMKRKAA

CYP108H1 Ectocarpus bacterium, 49% to CYP108G1 Caulobacter crescentus CB15 AE005918

1535540 MGAASHKAQTSLSELVAPIFNPASFSHRDKIDG
1535639 IFTTLRQDNPLACVEVPGYDPHWMVTKYSDVKEITRQDNLFHSGDRPKILHSQAGEA 1535809
1535810 LARSFTGGSPNLFQSLVQLDPPEHTAYRNVLQGEFMPGGIAKMKENVAKTAQEFVDQMAS 1535989
1535990 LAPTCDFADDVAMNYPLQVVLDIVGVPREHHPKMLQLTQWLFSYADPDLKRPGSDIT 1536160
1536161 DPEEIIKTWNVVFTQFHEFFMPLVEARRANPKEDIASLIANAKINGESMEERKMISYFG 1536337
1536338 ILATAGHDTTSATTALGMKMLAENPDMLARLKEKPDLIPSFVEECIRWGSPVQHFIRSAT 1536517
1536518 EDYVLRGQTIRKGDLLYISYLSANRDEEEFDDPFTFKMDRAPNRHVGFGFGGHVCLGQH 1536694
1536695 LARLEIRTIWQTLLPRLTEVELTGPVKFTESEFVCGPKSVPIRFKMDG* 1536841

CYP108H2 Marine metagenome 1093018949056, AACY022454370, 57% to CYP108H1

APPRRGPQQSAEHTETWNRVYKEFEEYYEPVIKDRQTCPREDLASLISNGKIDGCPMEHR
AQISYFIIASTAGHDTTSATLATAISVLAERPEVLEQLKANLELIPAFIEETIRWASPVK
HFLRHATQDYELRGQQIKKGDLMYLSYISGNRDEDLIEDPFEFRIDRKPNRHVAFAFGNH
ICLGQHLARLELKIMLEELLPRLESLQLTGKPKLAISDLVCGPKSVPIQYDFKRTA*

CYP108-un1 Mycobacterium smegmatis

LTDHYAMAHPKALNDTPDTAQPGQPQTRNPTTPGDLPPLQFFARTVHAET
SLGGVQFSENQRLVMNLAAANRDPRQFDDPESFDADRPRNPHVAFGGGLH
SCQGQHIARAEMRAVLRVLLTRLPDVHLTGEVGEAGVLAGLMAVISLPVA
FTPERSQT

CYP109A1 Bacillus subtilis

MTNQTARSSKKERYANLIPMEELHSEKDRLFPFPIYDKLRRESP
VRYDPLRDCWDVFKYDDVQFVLKNPKLFSSKRGIQTESILTMDPPKHTKLRALVSRAF
TPKAVKQLETRIKDVTAFLLQEARQKSTIDIIEDFAGPLPVIIIAEMLGAPIEDRHLI
KTYSDVLVAGAKDSSDKAVADMVHNRRDGHAFLSDYFRDILSKRRAEPKEDLMTMLLQ
AEIDGEYLTEEQLIGFCILLLVAGNETTTNLIANAVRYLTEDSVVQQQVRQNTDNVAN
VIEETLRYYSPVQAIGRVATEDTELGGVFIKKGSSVISWIASANRDEDKFCKPDCFKI
DRPSYPHLSFGFGIHFCLGAPLARLEANIALSSLLSMSACIEKAAHDEKLEAIPSPFV
FGVKRLPVRITFK

CYP109B1 Bacillus subtilis

MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE
NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP
RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA
WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE
ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV
EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR
HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF
RVKM

CYP109C1 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_111

MNLFPDEMRR DPYPLYDQLR TGSPVFHVAP LDLWMVFDYD GVKRALTDHE AFSSAVAPPT
GKAPDWIVFS DPPRHTKLRS IVLRAFTPRS IAGLEPRIRE LSRDLLDPWI ERGEMDLAAD
YAGPLPTMVI AEMLGVPPED RARLLRFSEV IVNLSHAISG GEEAARAVSE HAVVKEEMKV
YLAGLIEARR RAPAEDLLTR LVEAEVDGER LTEGDILNFF QFLLAAGTET ATNLIDNAIL
CFLESPAELF RLRAAPELLP SAIEEVLRHR SPLQMVFRET RRAVEVHGQV IPAGKLVLPV
IGSANRDPHQ FHDPGRFDIG RDPNPHVAFG HGIHFCIGAA LARLEARIAL PDLLCRLKGL
RRASDEPWEP RKAIIVHGPA RLPIRFEPGR RAAVHAAGAH TPCPG

CYP109C2 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_8140

MNLFSEEMRR NPYPAYDQLR SRTPVLHYPP SDSWLIFDHD GVKRALHDHD AFSSVVSPPG
TRTAEWLIFS DPPRHTKLRA LITRAFTPRA VAGLEPRIRR LSRELLDRTI ESGQMDVAED
YAVPLPLLVI AEMLGAPAAD QPHFKRWSDA ILDLSHTVSG SEEAARALDA FTAVTAEMQA
YLRGLVEQRR AAPEDDLLTR LVEAEVDGER LNEDEILGFF QLLLVAGHET TTNLIGNAML
CFLENPDELA RLRAAPELLP SAIEEVLRYR SPVQAMFRVT RRDVPMHGQV IPAGKAVLAM
IGSANRDSQQ FRDPDRFDIA RDPNPHIAFG HGIHFCIGAP LSRLEARVAL ADLVARLGGL
ERASDAPWEP RRAIHVHGPA RLPIRFAPGP RLGGAPG

CYP109D1 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_4257

METETAPSPS PEQIDLSAPS VIADPYPAYR ALRGRSPVLY ARVPAGGAAG LGEPIRAYAL
LRHAEVLAAL RDPQTFSSNV TDKIRVLPRI TLLHDDPPRH THLRRLVSRS FTPRRIAELE
PWIGRLAASL LEATGDGPSD LMGAYAMPLP MMVIATLLGI PAERYVQFRS WSESVMSYSG
IPAEERASRG KAMVDFFAAE LEARRRAPSG DLISALVEAE IDGARLDTPE AVGFCVGLLV
AGNDTTTNLI GNMAHLLSER PELYRRAQQD RSLVGPIIEE TLRHSSPVQR LLRVTTRPVD
VSGVMIPAGH LVDVVFGAAN RDPAVFEEPD AFRLDRPPAE HLAFGQGTHF CIGAALARME
ARIALNALLD CYESITPGEA PPLRQTRAIM PLGFESLPLV LRRSRATA

CYP110A1 Nostoc sp. PCC 7120 same as Anabaena sp. PCC

1 MLTQLPNPIS VPSWWQLINW IADPIGFQKK YSKKYGNIFS MQLAGIGSFV ILGEPQALQE
61 IFTQDSRFDV GRGNTLAEPL IGRTSLMLMD GDRHRRERKL LMPPFHGERL QAYAQQICLI
121 TNQIASEWQI GQPFVARSAM QKLSLEVIIQ IVFGLADGER YQQIKPLFTD WLNMTDSPLR
181 SSMLFLKSLQ KDWGTWTPWG QMKHKQRSIY DLLQAEIEEK RTKENEQRGD VLSLMMAARD
241 ENGQAMTDEE LKDELLTILF AGHETTATTI AWAFYQILKN VNVQEKLQQE LDRLGANPNP
301 MEIAQLPYLT AVSQETLRMY PVLPTLFPRI TKSSINIAGY QLEPDTTLMA SIYLIHYRED
361 LYPNPQQFRP ERFIERQYSP SEYIPFGGGS RRCLGYALAL LEIKLVIATV LSNYQLALAE
421 DKPVNVQRRG FTLAPDGGVR VIMTGKKSLK FEQSSKIFN

CYP110A2 Anabaena variabilis (a cyanobacterium)

MLTQLPNPISVPSWWQLINWIADPIGFQKKYSQKYGDIFSMQLA
GIGSFVILGEPQAIQEIFTQDSRFDIGRGNKLAEPLIGRTSLMLMDGDRHRRERKLLM
PPFHGEKLQAYAQQICLITHQIASQWQIGQPFVARSAMQKLSLEVIIQIVFGLANGER
YQQIKPLFTDWLNMTDSPLRSSMLFLKSLQQDWGNRSPWGQMKYQQRCIYDLLQAEIE
EKRTKENERRGDVLSLMMAARDENGQAMTDEELKDELLTILFAGHETTATTIAWAFYQ
IFRNVNVREKLQQELDSLGENPNPMEIAQLPYLTAVCQETLRMYPVLPTLFPRITKSS
INIAGYQLEPNTTLMASIYLIHYREDLYPHPQQFRPERFIERQYSPSEYIPFGGGSRR
CLGYALALLEIKLVIATVLSNYQLALAEDKPIKVQRRGFTLAPEGGVRMIMTGKKSLR
FEQSNKIFN

CYP110B1 Nostoc sp. PCC 7120 Same as Anabaena

1 MHLPKGPQTP VFVQVLRWVF SPMSFLEDCA KRYGDIFSVK LAKDVPAIVF LSNPKDIQQI
61 LTNDNNQLDS PGDWNDLFEP LLGKRSVITL SGAEHQRQRQ LLMPPFHGER MRGYSQVITD
121 VTEKVISQHQ IGQPFQVRSV TQAITLRVIM QAVFGLYEGS RAEKLQHLLS DLLEKSSSPF
181 SVALLYFPSL RRDFGPIKFW GEQVQIQQQA DELIYQEIQE RRENPDPSRT DILSLLMDAR
241 DADGQPMTDV ELRDELMTLL VAGHETTATA LAWAMYWIHK LPPVKARLLE ELDSLGDNPD
301 STTIFKLPYL NAVYSETLRI YPVAMLTFAR RVIETMALGG YELPPGTPVL GSIYLTHHRE
361 DLYPEPKKFK PERFLERQFS PYEYLPFGGG TRRCLGLAFA QWEMKLALAK ILTSYELELV
421 NNSVEVRPKR RGLVTGPHRP IEMVIKSQRQ ITSRILETTT VS

CYP110B2 Nostoc punctiforme

MKLPKGPQSPAVLQMLRWITSPMSFMETCAKRYGDMFTIRLDSK
SPPLIFVSKPEVLEQILTNDIKGLEAPGDTNLVFESLLGKHSVITISGAEHQRQRQLL
LPPFHGERMRSYSQIISDITEKVISQYQIGQPFNIRSVTQAITLRVIMQAVFGLDEGP
RAEKLQHCLAEMLEKGSSVLSAALLYFPALQRDFGPINFWGKQMRRQQAADKLIYEEI
RERQEQPDPSRTDILSLLMAARDEAGQPMTDEKLRDELMTLLVAGHETTATALAWAFY
WIQKIPTVRQKLLKELDSLGDNPDPSTIFKLPYLNAVCSETLRIYPVAMLTFARVVRT
PLSLGGYELEPGIGVIGSIYLTHHREDLYPEPKQFKPERFLERQFSPYEYLPFGGGAR
RCIGLAFAQLEMKLALAKILSTRELELVDNSEVRPKRRGLVTGQDRPIQMVVTSQRQV
KFPILQTATV

CYP110C1 Nostoc sp. PCC 7120 Same as Anabaena

1 MKYQIQRPNP LKTHPFLQKL QWIADPVEYM KKASLQHPDM FTAEVIGFGD TVVFVSHPQG
61 IQTLFANDRK KLVAVGEANR ILYPLVGNNS MFLLEGVKHK QRRQLLMPSF HGERMREYGH
121 LIRNITENLF SQLQQDVTFS ALTAMREISM QVILQAVFGF YEGERCQQFK HLLPIFLSEL
181 FQSPLASSIL FFPSLQKDLG NLTPWGRFVR QREKIDKLLY AEIAERRQEI NSDRIDILSL
241 LISARDETGD SMSDKELRDE LITLMISGHE TTGTAMAWSL YWILQTPEVF QRLIQELDSL
301 GDSPDPMSIF RLPYLTAVCN ETLRINPVAM LTLPRVVKEP IELLGNRLET STTVVGCIYL
361 THHREDLYPE SKLFKPERFL KREFSQYEFM PFGGGVRGCI GQALAMFEMK IVLATVLSRY
421 QLALADRKPE RPQRQGFTLT PTNGVKMLIT GQHKRQNYSM AASTTFNA

CYP110C2 Nostoc punctiforme

1 MQLPNILKSP SLLQKLHWVS DPIGYMENAA QEYPDIFTGK IVGFGDTVVF VNHPQAIQEI
61 LTNDRKKFTA VGELNGILKP LLGDNSVLML ESDRHKRQRQ LVTPSFHGER MQAYGQLICN
121 VSKKIFNQLP LNKPFVARNL TKEISLQVIL QSIFGFYEGE KIQKLRQLLP LLLELFESPL
181 SSSLFLFSFL QQDLGAWSPW GNFLRVREKI DQFLYTEIAE CQQQADPERI DILSLLISCR
241 DEAGQPMTDQ ELRDQLITLI LAGYDTTATA MAWGLYWIHK QPLVCEKLLQ ELDTLGDSPD
301 PMSISRLPYL TAVCNETLRI HPVTMFSFPR VVQEPLELLG HSLEPGTILL PSIYLTHHRE
361 NLYPQSKQFK PERFIERQFS PYEFLPFGGG VRRCMGEALA LFEIKLALAT IVSHYHLALV
421 DQRPEQPQRR GFNLAPGSGV KMVMTDQRAR KESLINMTTT PLS

CYP110C3 gi|75908202| YP_322498 Anabaena variabilis ATCC 29413

95% to 110C1
MKYQIKRPNPLKTHPFLQKLQWIADPVEYMEKASLQHRDMFTAEVIGFGDTVVFVSHPQGIQTIFANDRK
KLVAVGEANRILYPLVGNNSMFLLEGVKHKQRRQLLMPSFHGERMREYGHLIRNITETLFSQLQQNVTFS
ALTAMREISMQVILQAVFGFYEGERCQQFKHLLPVFLSELFQSPLASSILFFPFLQKDLGNLTPWGRFVR
QREKIDKLLYEEIAERRQEINSDRIDILSLLISSRDETGNSMSDQELRDELITLMISGHETTGTAMAWSL
YWILQTPEVFQRLIQELDSLGDSPDPMSIFRLPYLTAVCNETLRINPVAMLTLPRVVKEPVELLGNRLES
GTTVVGCIYLTHHREDLYPESKLFQPERFLKREFSQYEFMPFGGGVRGCIGQAIAMFEMKIVLATVLSRY
QFALADGKPERPQRQGFTLTPANGVKMLITGKHQRQNYSTAASTTFTT

CYP110C4 gi|119510163| ZP_01629302 Nodularia spumigena CCY9414

MSTPNRLKTPAFFQQLQWVADPVGYMEKAAQQYPDIFTAQVVGFGNNLVFVNHPQAMQEILTNDRKKLFA
GGKENKILQPLLGDYSMIMLDGDRHRKRRQLVMPSFHGDRMRSYGEIISNITEEVWSNLPTDKSFLARNV
TQDITLQVMIQAVFGVYQGERSQQLKKQLELMANIFRSPLSSSMLFFSSLQQDLGAWSPWGKFVRDRQEL
DNLIYTEIAERRQQNLENRIDILSLLMSAEDESGNPMTVQELRDELMTLLFAGYETTATALAWGLYFIQK
HPEVQEKLLQELDTLGDSPDPMSIFRLPYLTAVCNETLRIHPVAMLTFPRTVKEPVEISGYALDPGTILV
GSMYLTHQREDLYPEPKQFKPERFLERQFSPYEFIPFGGGVRRCVGEALAVFELKLVLATILSRYELALT
DDQPEVPRRRGVTLAPGRGVNMMITGQRLA

CYP110C5 gi|67925622| ZP_00518945 Crocosphaera watsonii WH 8501

MKTIPTPKTPTLVQQLQWVLNPTGYLQTNHHRYPDLFKAKIIGLGNDIILISNPEIMQYILTHDRQEFTA
PSSLNTLLKPLLGDYSVVMLDGDGHRQRRQLVMPSFHGERLKVYGDLTCRITREAMEKLPENQPFLAREV
MQDISLKVIMEAVFGVTEGERYEELQYRLKELLDLFDSPITSGFLFFPSLQKDLGNWSPWGYFLRQRQAL
DKLIYAEISDRRANPDPERTDILSLLMFAKDEQGESMKDQELRDELITLLMAGHETTASAMAWALYWLHH
IPEIKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRLAQQTVEVGGYTFKPGDIVA
GCLYLTHLREDIYANPKQFNPQRFLDHKYSAYEFIPFGGGSRRCMGEALAKFEMKLVIAIIISEYCLKLA
DTQPEKQQRRGLTLSPKRGVKMILEGKRQPQKARELELSTR

CYP110C6 gi|126660859| ZP_01731952 Cyanothece sp. CCY0110

MKTIPGSKTPKLIQQLQWIFNPTKYLKTNHRRYPDIFKAKIIGFGDKMILTSRPEIMQYILTHDRKQFTS
PSGLNAILRPLLGDSSVLMLDGDRHRQRRQLVMPSFHGERLKVYGDLTCRITEEVMAKVPQNQPFLAREI
MQDISLKVIMEAVFGVTEGKRYEQLQDRLKKMLDLFNSPLTSAFLFFPFLQKDLGSWSPWGHFLRQRQAI
DELIYAEISDRKAHPDSDRTDILSLLMSAKDEQGQGMKDQELRDELMTLLTAGHETTASAMAWALYWIHH
TPEVKDKLIEELNTLSPDAEGMDIFRLPYLTAVCNETLRLSPSAMLTFTRVAQEKVEVAGYTFEPGDMIM
GCMYLTHLREDLYTNPEQFNPQRFVDRQYTPYEFIPFGGGSRRCVGEALAQFEIKLVIATIMSQYCLKLA
DTQPEKQQRRGVTLSPARGVKMILEGKRQPQPVRELELSRQ

CYP110C7 gi|119486461| ZP_01620519 Lyngbya sp. PCC 8106

MKTLNSPKTSPLIQRLQWVFNPLEYMETNVKINRDIFNTQVTGGVGLIFVNSPEGMQELLTRDTKEFYAP
GSINEILKPLLGEQSVMLLDGDRHKRQRKLLMPPFHGERMRTYGELILNITQQATAKLKPGQPFIARNAM
QEITLAVILQAVFGIYEGSRYDKLKQLITSLLAVTDSPVSSSLLFFTSLQKDWGAWSPWGRFLRMRQKVD
QLLFAEIEERRQNWDENRTDILNLMMAARDEDGQPMADEELRDELLTLLVAGHETTATAMAWALYWIHRQ
PEVYQKLIQELESLPENADPMTIFRLPYLTAVCNEALRIYPVAMLTFPRVTKEPTQLLGYELEANIGLAG
CIYLLHHREDLYPEPKQFKPERFLERKFSPYEFLPFGSGARQCIGMALAQFEMKLALAQILLDYDLTLLE
KRPVKAARRGVTLSPVGGIKMMMNGKRTPSKSVAIPATV

CYP110D1 Nostoc sp. PCC 7120 Same as Anabaena

1 MTVTQNLPNG PRIPRLLRLF KFITQPIQYV EDFAKVYGDN FTIWGSGESY FVYFSHPQAL
61 EQIFTNVSCF ESSGGGSPLL ELLLGKNSLI LLEGDRHQRQ RQLLTPPFHG ERMRAYGQTI
121 REITQQVTQA WQMGKPFNIR ASMQEITMRV ILRVVFGVDE GELFQELRQL LTTLLDFMGS
181 PLMSSTFFFS FTQKDYGAWS PWGRMVRLIK KIDQLIYALI AQRRAEFGEN RQDILSLLIS
241 ARYDDGQPMS DVELRDELMT MLVAGHETTA SALTWAFYWI DSVPEVREKL FQELDTLNDD
301 SEPSIIAKLP YLTAVCQETL RFYPIVLNAF FRRTKNPMEI MGYKLPKATL VVPSIYLAHH
361 REEVYPQSKQ FRPERFLEKQ FSPYEYLPFG GGNRRCIGLA FAQYEMKIVL ATILSQFQVS
421 RLSKRPVQPV RRGLTLAAPG GMKMVANKRM RNS

CYP110D2 Nostoc punctiforme

MNIPLSVTLSNMKSRNNKIQKPSNLQTPMTATYNLPDGPQMPRW
LRTIKFISQPVKYVDDFAKTYGDTFTIRSSRSDNHIVYFSQPQALEEIFTADSRHFEV
GRGNTGLRFLLGDRSFMLVDGDRHQRQRQLLAPPFHGERMRAYGEDIRKITQQVSHEW
KIGKPFNIRESMQEITLRVILRVVFGLNEGELFEELRRSLSDLLDFISSPIMSSAFFF
RFIQKDFGAWSPWGRILLQRQKVDLLIYTLLRERRAQTDQNRQDILSLMMAARYDDGQ
GMSDEELHDELMTLLVAGHETTASALTWAFYWIDHLPEVREKLLQELNTIGVNPDLSS
VAKLPYLTAVCQETLRIYPIAMTAFVRIVKTPITIMGYELREGTAIVPSIYLAHHREE
VYPQSKQFKPERFLERQYSPYEYLPFGGGNRRCIGMAFAQYEMKIVLATVLSEFQVSL
VNKRPVHPVRRGLTVATPAGMRMVATPQVKRANTPALV

CYP110D3 Trichodesmium erythraeum

MTLPDGPSLSPLQRRLRTWKFIFSPLSAIEERYSEYGDIFRTNT
NSLYPFIYFCNPKAIQQIFTADPDTFTSGSINGILKYFVGLNSLLLQDGDRHKRQRKL
LMPPFHGDRMRKYGDLIYNITSNVISQWKIEQPFPIRKSTQEISLKVILAAVFGLDQE
GKSYEKLRVLMSDLLDSMSSPLSSTFLFFNFLRKDWGPWSPWGRFLRKKQELHELIIA
EIQTAKKEGNHRDDILSLLLEARDEAGNAMSDEEIKDELLTMLFAGHETTASALAWAL
YWIDMIPSVGEKLMAELATIPSNSDQVAITKLPYLSAICQETLRIYPIAMNAFPRVVQ
KPIEIMGYQLEPGMVAIVPIYLTHHREDIYPEPKKFKPERFLERQFSPYEYLPFGGGS
RRCIGSAFALFEMKLVLATILSQWELKLLPNQRISPVRRGLTMAPPANMRMVVKPKKS
WQKVSQPILTSG

CYP110D4 gi|119486457| ZP_01620515 Lyngbya sp. PCC 8106

MTLPNGPQTPRVLRMMKFVARPLDYLEDYYRRYGDFIRIGKSATPLVYVNHPAAIEKIFTAGSEQFRTGN
AGGVLLFLLGDNSVLMVDGERHERQRKLLMPPFHGERLKTYNQLICEITKEVMSQVKIGQPFRVRTLMQD
ITLRVILKAVFGLTEGERYEQLRHLLSAMMESIGSPLAASLMFFPSLRQDWGEWSPWGRFLRYKQQADEM
IYAEIRERKQQRDFDGDDILTLLMSARDETGKPMNETELRDELVTLLIAGHETTASSLTWALYWTHYLPE
VKDKLCFELANLGENPHLSEIARLPYLTAVCNETLRIYPVTLTSGVRVLKKPLELGGYSFEPGTVLFPCT
YLVHQREDIYPEPKKFKPERFLQRQFSPYEFFPFGGGHRRCIGSAMATLEMKIALATILSDWQLKLPHHK
AYKPVRRGLTLSPPAQLSLVAVNRLN

CYP110D5 gi|67920042| ZP_00513562 Crocosphaera watsonii WH 8501

MNLPPTLSQPRLLRLFKLIFYPLDYLEDNYQRYGDIFVAGKSETPFVYISNPQGIQTILTRDKTDFKTGG
GSGFLSTLLGDNSLLFLQGERHRRERKLLMPPFHGERLKSYANLIYSISDKVTDKLQINRSFNVRDIMQE
ITLKVILKAVFGITEGERYQRLQELLKSWLSFFDSPANAILIFFPWLRKNWGNWTPWGRFLQIKAEIQEL
IYTEIRERREQKKYEGTDILTLLMLAKDEEGKPLSDQELHDELITLLIAGHETTASALTWALYWIHFCPD
VEDKLRFHFSNLNNNTDLLDIVKLPYLDAVCKETLRIYPVLLTTFIRVLQTPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSQQFRPERFLERNFSPYEYFPFGGGSRRCIGMELAKMEMKIVLYTILSKHKLKLPSSR
PLKAVRRGLTVAPPSNFKMILSN

CYP110D6 gi|126654866| ZP_01726400 Cyanothece sp. CCY0110

MVLPPSISTPRLLRLFKLIFYPLDSLENYYERYGDIFIVGQSETPFVYISNPQGIQEILTKDKTHFRTGG
GSGFLTTFLGNNSLLSLKGEKHQRERKLLTPAFHGERLQSYATLIYSISDEVSEKLEINQSFNVREIMQE
ITLQVILKAVFGIAEGKRYQKLKNLLTSWLSFFDSPINATIIFFPFLQKDWGNWTTWGRFLRIKAQIDDL
IYTEINERRQQKNYQGKDILTLLILARDEDGNPMSDQELHDELITLLIAGHETTASSLTWALYWIHYCPE
VEEKLRSHFSILDKNIDLLNIIKLPYLDAVCSETLRIYPVVVNAFIRVLETPLELMGYQFKPGTVFAPAI
YLVHHREDIYPNSKQFRPERFLERQFSPYEYLPFGGGSRRCIGMELAKMEMKIVLFTLLSKYKFKLSSSH
PLKPVRRGLTIAPPNSFKMIITQKLAYT

CYP110E1 Nostoc sp. PCC 7120 Same as Anabaena

1 MKLPDSPKIP KFMQLVQWIY QPLQLMEASA KAHGDSFTLW LTNKRPIVFL SNPQAIQELF
61 TTPLEQLDAR GTAQVLQPLL GENSLLLLSG ETHQRQRKLL TPPFHGDRMR AYGDIITNIT
121 KEVISNWQLG KPFSVRDSMQ EITLRVILQA VFGLREGERY TQLQKRLCDI LDLSGSALRS
181 TLSFLPALQI DLGRWSPWGH FLRQREAIDQ LLYAEIQDRR DHPDPSRTDI LSLMMAARDE
241 NGEAMTDVEL RDELMTLLVA GHETTASALT WALYWIHKLP QVREKLLAEL DNFGDNGDVN
301 EITRLPYLTA VCQETLRIYP IAMVTIPRIT KTNLEIGGHQ FAPGTMLVGC IYLMHRRPDL
361 YPQPQEFKPE RFLEKQYSLY EYLPFGGSNR RCVGMAFALY EMKLILATVL ANVDLALVDN
421 YPVKPTRRGV TLAPSGGKWL IATAQHQKIK NPVEV

CYP110E2 Nostoc punctiforme

MSLLKLPNGPQTHPWIQMYQWLTNPLEYMEACTKRYGDIFTLKL
GQNFAHQVFISNPQAIQQIFTTDPKQLDSGESAGIKAPLLGQQSLLALDGKPHQRQRK
LLTPPFHGERMLAYGELIREITEQVSSQWQVGETFAVLPSMQAISFQVILKAVFGLED
GPRYKKLNELLIKILNPKIPLLRTVLLIFPSMRQDLGAWSPWGKYLRLRQQIDQLIYA
QIQERKAQPNLSGTDILSLMMAARDEAGEPMTDLELRDELMTLLVAGHETTATSLSWA
LYWIHHRPQVREKLLQELDNLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMSALNRLV
KSPLQIGEYNFEPGTILIPSIYLTHHREDLYPESKQFKPERFLERQFSPYEYLPFGGG
NRRCIGMAFALFEMKLVLATVLSRWQMELADSKPVRPVRKGLLFSPAGGVQMVVKGKR
LQNQPILQTSSSSV

CYP110E3 Trichodesmium erythraeum

1 MIKLPGPKSP ALTQILQWTA KPIKFMEKCA REYGDTFEVK LNYPIVFISH PKAIEEIFKA
61 NPKKFDCGSS NKLAQPLLGD YSLLLLDDIP HQRQRKLLMP PFHGKRMQAY GELICNVAQE
121 VASKWEIGQV FSMREFTAEI SLKVILQAVF GLYEGERYSK LEKLLGSLLE SLSSPLKTSM
181 LFFQFLQIDL GPWSPWGNFI KNREEIYELL CAEISERRQK LDPERSDILT MLLLARDEEG
241 EGMSDIELRD ELMTLLIAGH ETTATSLSWA FYWIHHQPEI YQKLSRELET FGDDLNPMTV
301 INLPYMNAVC SETLRIYPVV IIVSPRKTKL PITIMGQT

CYP110E4 gi|37522632| NP_926009 Gloeobacter violaceus PCC 7421

MSLPPGPSSPSPFQLMQWIGCPTDYLHTTAARYGDPFTMRVGVFPPLVMFSDPRAIQQLFTAEAGTFDAG
ASNVALRPTLGANSLLLLDGERHQQQRRLLTPPFHGERMRAYGELIRQVTEEVIVRWQPGKPFLVRNAMQ
RISLAVILQAVFGLHDGTRLVRLRQALGSMLDAMSSPLSMAMLLMLPEDFGPWSPRARLQAHLGAIDELL
YAEIRERREHFDAGAGDILGLLLAARDEAGAAMGDAELRDELMTLLVAGHETTATAMAWALYWIHYLPQV
RERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVALIASPRVARHTVRILERDYEAGTRLAAGIY
LAHHRPETYPEPERFRPERFLERTFSPYEFVPFGGGSRRCIGMAFALYEMKLVIATVLLERDLRLVQPRL
LRPVRRGVTLAPPEGLYLVPTGERSASRLLSRTSTAGQ

CYP110E5 gi|37522633| NP_926010 Gloeobacter violaceus PCC 7421

MSLPAGPASPPPLQLLQWIGRPTDYLERTARRYGDPFTMRLGLHSPVTGVFFSSPEAFQQLFNTEPGLFD
SGGANASSTFNLLFGTNSLILLDGERHQQQRRLLTPPFHGERMRSYGELIRTLAEQVTARWNLGTPFQAR
RSMQRISLGVILKAVFGLHDGTRYLRVCRLLGNLIDASASPLLFGLRLIFPQDAGPMSPMGQLKAQIDAI
DELLYAEIRERRERPDPRADDILSLLMAARDEAGQGMGDVELRDELMTLLVAGHETTATAMAWALYWIHR
LPQVRERLLAELDSLGSDPDPEAIARLPYLGAVCSETLRIYPVAMVAFARVPRRPVRILDREYPAGTFLI
PNIYLAHRRPEAYPDPERFRPERFLERTFSPYEFVPFGGGSRRCIGVAFALYEMKLVLATVLSRVELRLA
DPRPRLPVRRGLTLAPPEDLHLIPTALRSGHRDLLPAC

CYP110E6 gi|75908324| YP_322620 Anabaena variabilis ATCC 29413

MKLPDSPKIPRFMQLVQWIYQPLQLMEASAKAHGDCFTLWLTNKRPIVFLSNPQAIQELFTTPLEQLDAR
GTAQVLQPLLGENSLLLLSGETHQRQRKLLTPPFHGDRMRAYGDIITNITQEVISKWQLGEPFSVRDSMQ
EITLRVILQAVFGLREGERYTQLQKRLCDILDLSGSALRSTLSFLPALQIDLGSWSPWGHFLRQRAAIDQ
LLYAEIQDRRDHPDPSRTDILSLMMAARDENGEAMTDIELRDELMTLLVAGHETTASALTWALYWIHKLP
QVREKLLAELDNFGDNGDVNEITRLPYLTAVCQETLRIYPIAMVTIPRIVKTTLEIGGHQFAPGTMLVGC
IYLMHRRPDLYPQPQEFKPERFLEKQYSLYEYLPFGGSNRRCVGMAFALYEMKLVLATVLANMDLALVDN
YPVKPTRRGVTLAPSGGKWLIATGQHQKVKSPVEV

CYP110E7 gi|119512554| ZP_01631632 Nodularia spumigena CCY9414

MPALQLPDGPKNHPWLQTYRWLTSPLEYMEDCAKNYGDIFTIRVGPLSTPQVFVSNPQAIQQIFSTDPKY
LDSGAAAGFKSPLLGNQSLLSLDGKPHQRQRKLLTPPFHGERMLAYGELIRDISQQVTNKWQVGETVSVL
SSMQAISFQVILKAVFGLAEGPRYEKIKEALIAILNPKKPLLRSMLLMFPSLRRDLGAWSPWGEFLRLRQ
QIDELVYAEIQERKAQLDSSRTDILSLMMATRDEAGEPMTDLELRDELMTLLVAGHETTATALSWALYWI
HHQPQVREKLLQELDTLGEKPDPNAIFRLPYLNAVCSETLRLYPVAMLLLSRLVKSPLQIGEYQFEPGTL
LIPCVYLTHHREDLYPDSQTFKPERFLERQFSNSEFIPFGGGNRRCIGMAFALFEMKLVLATVLSNWQME
LANTQPVLPVRKGLLFGPKGGVQMVVKGRRELS

CYP110F1 Nostoc punctiforme

MKILDSLTTPSLLQTLQLIAKPTKTLENYATKYGDIFTMRVMGL
KSPPIVFFSHPQAISDCFAVPAHKLDFKKATHVFKPLFGENSIVFKEARSHQQQRQLL
LPAFHGDNLKSYGQAICQIAEELTQSWTSGTNICIHKLMSKITLEIILQVVFGITHGV
RYQQLKEQLSALLEDVTKPWYSSLFFFPSLQKDLGAWSPWGIFLKRREQIDKLIYAEI
SERRWQNDAMRTDILSLLMSAHDVNGQQMTDEELRDQLVSLLLLGYETTSGVLAWIFY
LIHSHPEVKHRLMQELSTLDNLTNPEAITQLPYLTAVCQETLRIHPIALICTPRMLKE
PVEIMGHKFTSETVLVPCIHLAHRRTDTYPEPEQFRPERFLNQKFSPYEYLPFGGGYR
GCIGAAFSMYELKLVTAIILSRFELSLTDKRPAYPVRRGITIVPSGGVKMVVTKKAKF
KRQTILST

CYP110G1 Trichodesmium erythraeum

1 MKQVCALKTP LWLQRFNYIT NPVSYWQKAY SSYKDAFYAQ GINFGKPLMV FYTPSAAKQI
61 IENCQGDLTT TSFDSELTAI FGDSSFFILE GTNHKKMRKL LIPALHGKHI KTYGELICNL
121 VNNLIENLPF NQSFSALEIA QEISMQVMIK LLFGNYQQER YQKIKQLMIN MVSLFAANVF
181 GFPLFFKFLQ QDLGLVSPWG NFLQQRRKIQ QLIYQEIAER RNHPNQERTD ILSLLMTAQD
241 EKGNFLNDEE LLGQLLSLLF TGNESTAASI AWSWYEVYRN SKIKEKLLEE INNLGDSPEP
301 LSLFNLPYLS AVCNETLRKY PVTMFMIPRI VKNTTEINGY QLDKGMLVTV GTYILHHRED
361 IYDQPEEFKP ERFIEHRFSS FEFLPFGRGM RGCIGADIAL YQMKLTLATI ISHHRLELTN
421 YGQIFPKRRN TILTPIKLRI IKAC

CYP110H1 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_2802

MSQLPRGPRS RLLTTYKFLT RPFEFLTHCA ATYGDVFNVP VVSGDVVIAG GPRTVQDVMT
APPETFLPFA TRAIAPLVGE HSLLMLSDER HRRERKLLTP PFHGDRMRAY AAAMADTAAR
RLTEAARAPR AVAQELTQAI SLDVIIRAVF GVEEPSRTSA FARAVVAMTD ALTPALTFLP
PLQRELGGLG PYARFRRRVG ELDALFRAQI ERARAAPGDD ILSLMVSARY DDGSRMSDQA
IFDELRTLLF AGHETTALAL AWALDHVHRH PGVLARLRDE IDALGPEPDP ERLAALPYLD
AVCKEALRVY PIVTESPRLL AQPFRLGEHE LLPGTGVAPC ILLVHHHPEL YPEPSRFRPE
RFLERKFSPF EYLPFGGGHR RCIGAAFAMF EMKIVLGVAL SAWEFRLLDE RPPRPVRRNL
TLSPSGGVPL VLRARGRSRL YAAA

CYP110J1 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_5885

MGNLPPGPKS LSLVDTIRAG FISSEPVFRR YAAEYGPTFR LRSPNGILTI TGDPEAIRAV
YTADPDEFDV WGVQLTEPVF GTSSVVVTAG ARHRRDRRLL APPFSAGAMR GYGDAIAEIS
LDVASRWRPG RSFSMLAATQ AIALDVIVRV VFGVRGEARV GRTREAVLGL IESLSPSFMI
IPALRRDFAG FGPYARHKRA ARALDALLFE EIRARRAEGD ASQDILGLMM SARHDDGAGM
SDVEIADQLR ALLFAGHETT AMSLGWAMYW LHREPAVLAR LLDELDTLGP APEADALASL
PYLEAVCLEA LRLHPPVVDV ARVVKRPFRL KGYTIPAGEA IAASPLLLHG REDLYPSPER
FRPSRFLDRK FTPFEFIAFG GGARRCLGAA FAMYEMKVAL GTILGRYRLR LESQAPIHHV
RRGLTMGPSG DVAMILEGER ERARAEGRPA AVQGSPAEPA LRPAAPQPAG RCPMGFS

CYP110K1 gi|126660674| ZP_01731775 Cyanothece sp. CCY0110

MTATIKAKKSNNLAFPQGIKRYGLKGILNLIFRPLPTLEAYRNRYGDIYYSPAFSSFPPFIVVSNSEGVE
ALFTADPDLFNSGTSNAAFQPLLGSQSILQLDGEPHKKRRKLLMPSFHGQRLQTYGEIITNITQSIISHW
QKEDIFSMREVTQEITLSVILQAVFGITQGNNYQSLRKQLGRYLDLFNSPLYTSTLFLPILQKNWGTWTP
WGNFIAQRDKVYELLSQEIDKRTTTKDGEDILTLLLSVIDEEGEHLTKSEVMSELMTLLFAGHETTASAL
AWAFYWIHFHPEIYHNLKDELDTIDLDTDPMEIAKLPYLSAVVSETLRIYPIALFAFSRTLTTSWEFMGY
SLDKGMSLAPCIYLVHHHPDIYPNSKQFKPERFLERQFSPYEFIPFGGSNRRCLGYALALYEMKLVLATV
LKQVNLKLVSSQPILPVRRGFTMSPQGGVKMQVI

CYP110L1 gi|113954988| changed from 110H1 YP_731620 Synechococcus sp. CC9311

MLEAILRPIAYYRRCFFRNSGVVRVRMSPTLPPQQVLISDPSVIKELINEDGGRHITAPGQLNGLLSQVL
GKHSIILLAPATHRQRRKLLTPPFHGERLKAYGQLISSLADQSLIDLNVGDVFDAREQMQGITMRVILTA
VFGLHEGDAFRQLERSLASSISIRSGPLGSLLLFFPFLRRDLGRWSPGGRIKAADAAIRRLLLEQIASRR
RAVERCGEENMSADILSLLLSCKDDEGQGLSDDELHDELLTLLFAGHETTATALTWAFYWIHRNPLVLER
LMNELNGLLDHSDPEAIARLPYLSAVVNEVLRIHPVAMLTFPRRIESAITLGGYAFRSGDVVMACIQAVH
ERPDLYPKPLQFNPERFMNQTYGLHEFLAFGGGSRRCIGAALALYEMKLILAKILLNNQFELTPKSNRWN
KPRRRGFTLGPSIPVKLKMVSLRP

CYP110M1 gi|119485435| changed from 110J1 ZP_01619763 Lyngbya sp. PCC 8106

MRLPDGPRLPALLQTLQIIAQPTQFLERCANQFGDCFTLRVLGFNSPPIVFFSNSEAIEAIFTTDTDKFE
LGKITHVFQPLTGSQSLIMQDGKRHQRLRQLLMPSLHSKQLPAYGQTICNLTLKATQNWSPGDFISIRDY
TSEIALEVILQVVLGLKENRRYFQLKHLIEPYLESVNKPLNSIQFFLPPLQQNLGQKSPWGKFLKQRKKI
DDLIYAEIAERRTKPLGEDVLSLLISAKDEAGQPLTDQELRDQLITLLLLGHDTTASALAWAFYWIHRYP
KIVNQLVEELNSLGENPDPMDIVQLPYLNAVCQETLRIHPIALISQPRVVKESIKIENYQFKPGTILVPC
IHLAHHREQIYPNSKQFNPNRFLEQKFSPYEYLPFGGGNRSCIGMALSLFEMKLILATILLNYQLAFNQS
HVVKPVRRGITIVPSINFRLTVLTRKQAGIASKSVNH

CYP110M2 gi|56750197| changed from 110J2 YP_170898 Synechococcus elongatus PCC 6301

MLPPGPSQLALLQTLRIITQPVSFLLSCADRYGDWFTLRVLGPQSPPVVFVSDPEAILAIFSSLADQLEL
GRIADVFRPLVGNESLIMQNGDRHRQQRQLLMPALQGERLFDYTPAMTAITQAAIAQWPLGQPLDLRRQM
SQISLAVILQVVFGLTPGPRYRDLYQRLDQLLEAITDPLYSLQFFWPALQQDWGNWSPWGRFCRQREAID
ALITAEIQEGRQSQQPRQDVLELLLAARDRDGNPLSDQELRDQLMTLLLLGHETTASALTWAVFWLLRHP
DCLNRLQSELVAIGDNDRAIAKAPYLDAVCREALRLQPIALIAQPRRVASPLSLGGYDFASGTILVPCVL
TAHRRAATYPNPDQFQPNRFLERRFSNGEFLPFGGGQRSCIGMALSLIEMKMVLATLLRQCQIAEVSQRP
VRPARRGITFVPSQDFRIQVQQWHNPSAQTAIASV

CYP111A1 Pseudomonas incognita

MERPDLKNPDLYTQQVPHDIFARLRREEPVYWNPESDGSGFWAV
LRHKDIIEVSRQPLLFSSAYENGGHRIFNENEVGLTNAGEAAVGVPFISLDPPVHTQY
RKVIMPALSPARLGDIEQRIRVRAEALIERIPLGEEVDLVPLLSAPLPLLTLAELLGL
DPDCWYELYNWTNAFVGEDDPEFRKSPEDMAKVLGEFMGFCQELFESRRANPGPDIAT
LLANAEINGQPVALRDFIGNLTLTLVGGNETTRNSISHTIVTLSQQPDQWDILRQRPE
LLKTATAEMVRHASPVLHMRRTAMEDTEIGGQAIAKGDKVVLWYASGNRDESVFSDAD
RFDVTRTGVQHVGFGSGQHVCVGSRLAEMQLRVVFEILSTRVKRFELCSKSRRFRSNF
LNGLKNLNVVLVPK

CYP111A2 Novosphingobium aromaticivorans

MLDLKNPDTYQGGVPYAALQDLRAEGPVHWNPESDGAGFWAVLG
HDEIVAVSRQPDLFSSAFENGGHRIFNENQVGLTGAGESAIGIPFISRDPPSHTQYRK
FVMPALSPARLQGIEERIAKRVERLFAQVPLGETVNILPLLTVPLPLLTLAELLGVPA
DLWPDLHRWTDAFVGEDDPDFRQSPEAMQAVLAEFMGFATALFEDRRANPGPDIASLL
ANTEIRGEPAPLRDFIANLILALVGGNETTRNSINHTMIALAENPGQWDILRADPSLM
TAAVKEMVRFASPVIHMRRTAMRDTQLGQQAICKGDKVVIFYPAGNRDPAVFENPDRF
EITRPVRQHLAFGSGAHVCVGSRLAEMQLRLAFAEMARHVRAFEVVGEPSRVRSNFIN
GFKRLEVRLLV

CYP111B1 ABS61652.1 Parvibaculum lavamentivorans DS-1

CDS  complement(33622..34875) locus_tag=”Plav_0029″
49% to CYP111A1 P450 lin L23310 Pseudomonas incognita
MLRPQAKAIDLNGKPDLKDPDLYLHEQHHEAFRRLRAEEPVYWNPEADGPGFWAVTRYDDIEAVSKNPKL
FSSAKHNGGHRIFNENEIGGNDTDASMISMDPPAHAGYRRMVTPGFVPKRISNMEERIRARVTRLLDAMP
KTGEAEFISAVAAALPIEVLAELFGVPESDGPKLFEWSNATVGEDDPELRVSDEYMQKCIMEMAGYAAGL
WQQRLETPGDDLISMLAHSKIGGEAMNFPTYIGTFILLVVAGNETTRNSISGGLLALSENPGERQKLLDD
PSLIPSAVQEIVRWVSPVLHMRRTATEDTELRGQKIRKGDKVVMWYASGNRDEAQWADPYRFDVARYAAP
GVPAQIGFGVGQHFCLGSRLAELQLTILFEELLRRFPDINVSGPIRRLRSNFIYGIKEMPVSYTPEG

CYP112A1 Bradyrhizobium japonicum

MSEQQPLPTLPMWRVDHIEPSPEMLALRANGPIHRVRFPSGHEG
WWVTGYDEAKAVLSDAAFRPAGMPPAAFTPDSVILGSPGWLVSHEGREHARLRAIVAP
AFSDRRVKLLVQQVEAIAAHLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDH
AFFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPDDNLLTDLLAAVD
QGKASEEEAVGLAAGMLVAGHESTVAQIEFGLHAMFRHPQQRERLVGDPSLVDKAVQE
ILRMYPPGAGWDGIMRYPRTDVTIAGEHIPAESKVLVGLPATSFDPHHFDDPEIFDIE
RQEKPHLAFSYGPHACIGVALARLELKVVFGSIFQRLPALRLAVAPEQLKLRKEIITG
GFEQFPVLW

CYP112A2 Rhizobium sp. NGR234 plasmid pNGR234a

MPEQPLPTLPMWRVDHIEPSPTMLALRANGPIHNVRFPRGHEGW
WVTGYDEAKAVLSDAAFRPAGMPPAAFTPDCVILGSPGWLVSHEGGEHARLRTIVAPA
FSDRRVKLLAQQVEAIAAQLFETLAAQPQPADLRRHLSFPLPAMVISALMGVLYEDHA
FFAGLSDEVMTHQHESGPRSASRLAWEELRAYIRGKMRDKRQDPGDNLLTDLLAAVDR
GEATEEEAIGLAAGMLVAGHESTVAQIEFGLLAMLRHPQQRERLVGNPSLVDKAVEEI
LRMYPPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPRHFEDPEIFDIGR
DAKPHLAFSYGPHYCIGMALARLELKVVFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEFPVLW

CYP112A3v1 Mesorhizobium loti

1 MSEQPLPTLP MWRVDHIEPS PEMLALRANG PIHHVRFPSG HEGWWVTGYD EAKAALSDAA
61 FRPAGMPPAA FTPDSVILGS PGWLVSHEGG EHARLRTIVA PAFSNRRVKV LAQQVEAIAA
121 QLFETLAAQP QPADLRRHLS FPLPAMVISA LMGVLYEDHA FFAGLSDEVM THQHESGPRS
181 ASRLAWEELR AYIRGKMWDK RQDPGDNLLT DLLAAVEQGN ATEEEAIGLA AGMLVAGHES
241 TVAQIEFGLL AMFRHPQQRE RLVGDPSLVD KAVEEILRMY PPGAGWDGIM RYPRTDVTIA
301 GVHIPAESKV LVGLPATSFD PRHFDDPEIF DIGRDENPHL TFSHGPHYCI GMALARLELK
361 VVVGSIFQRF PALRLAVAPE ELKLRKEIIT GGFEEFPVLW

CYP112A3v2 Mesorhizobium loti

GenEMBL AL672112 complement(85404..86606)
Strain R7A symbiosis island
Gene = msi071
2 DIFFS with CYP112A3v1

CYP112A4 Rhizobium etli symbiotic plasmid p42d

MSEQSLPTLPMWRVDHIEPSPEMLALRAKGPIHRVRLPSGHECW
WVTGYDEAKAVLSDAAFLPAGMPPADFTPDSVILGSPGWLVSHEGDEHARLRTIVAPA
FSNSRVKLLTQQVEAITVQLFDTLAVQPQPADLRRHLSFPLPAKVISALMGVPFEEHA
FFAGLSDEVMTHQHESGPRSASGLAWEELRAYIHGKIRGKRQDPGDNLLTDLLAAVDQ
GKATEEEAIGLAAGVLVAGHESTVAQIEFGLLAMFRHPQQRERLVRDPSLVDKAVEEI
LRMYSPGAGWDGIMRYPRTDVTIAGVHIPAESKVLVGLPATSFDPCHFKDPEVFDIGR
DANPHLAFSYGQHNCIGAALARLELKAIFGSIFQRFPALRLAVAPEELKLRKEIITGG
FEEMPVLWCGRPPASQSSHLAAPGAHRSDQPLDR

CYP113A1 Saccharopolyspora erythraea NRRL23338

MTTIDEVPGMADETALLDWLGTMREKQPVWQDRYGVWHVFRHAD
VQTVLRDTATFSSDPTRVIEGASPTPGMIHEIDPPEHRALRKVVSSAFTPRTISDLEP
RIRDVTRSLLADAGESFDLVDVLAFPLPVTIVAELLGLPPMDHEQFGDWSGALVDIQM
DDPTDPALAERIADVLNPLTAYLKARCAERRADPGDDLISRLVLAEVDGRALDDEEAA
NFSTALLLAGHITTTVLLGNIVRTLDEHPAHWDAAAEDPGRIPAIVEEVLRYRPPFPQ
MQRTTTKATEVAGVPIPADVMVNTWVLSANRDSDAHDDPDRFDPSRKSGGAAQFSFGH
GVHFCLGAPLARLENRVALEEIIARFGRLTVDRDDERLRHFEQIVLGTRHLPVLAGSS
PRQSA

CYP113B1 Streptomyces fradiae

MTTQTLEAEKPPEPERTANSVHPLAQPAGAGARGLLEWFARARA
EAPVFWDESRQAWQVFRYDDYLTVSTNPQLFSSDFSPVFPVPEELAILMGPGTFGGID
PPRHGPLRKLVSQAFTPRRIATLEPRIAEITRGLLDGLREKGQIDVVSDLAYPLPVIV
IAELLGIPAEDRDLFREWVDVILNNEGMEYPNLPDDFSETMGPAIKEWGDYLYRRIAL
KRETPTDDLMSGLIEAEVEGRRLTDEEIVNIVALLLTAGHISSATLLGNLFLVLDEHR
EAQAELRADRDLIPGAIEETLRYRSPFNNIFRLLKEDTDILGHPMKAGQMVVAWIASA
NRDSAHFSDPDTFDVRRQPNKHMSFGHGIHHCLGSFLARLEAKVFLELFFDEFSDYRV
EHDEVEFYEEDELTARRLPVTVTRH

CYP113B2 Streptomyces caelestis

MVDSVTGPMELSKDANAKELLDWFSHNRTHHPVFWDEGRQAWQV
FRYDDYLTVSNHPEFFSSDFTEVAPTPPELEMILGPGTIGALDPPAHGPMRKLVSQAF
TPRRMAGQEQRIRVIAEELLDRVRGQKTIA

CYP113B3 Streptomyces mycarofaciens

MSEAPTVPLELSKEANAQELLGLGSPSTGTHHPVFWDENWACLG
KVFRYDDYLTVSNNPQFFSSDFNEVMPTPPELEMVIGPGTIGALDPPAHGPMRKLVSQ
ALTPRRMARLGPRIRAVTQGLLDAVRGQETIDVVGDLSYALPVIVIAELLGIPSGDRD
VFRGWVDTLLTNEGLGYPSLPDNFSETIAPALKEMTDYLLHQIHAKREAPVDDLICGL
VQAEQDGRKLTDVEIVNIVALLLTAGHVSSSTLLSNLSLVLEENPQALADLRADRELV
TGAVEETLRYRSPFNNIFRFLKEDTDILGPEMKKGQMVIAWSQSANRDPEHFPEPDTF
DIRRSSSSRHMAFGIGIHHCLGAFLARQEGKVVLELML

CYP113C1 Streptomyces virginiae

MAQQTPPAPPSMADGGKAMLAWLRTMRDEHPVHEDQYGVFHVYR
HSDVLAVTSDPAVFSSDLSRLRPDSSALSEEILSVIDPPLHRKLRSLVSQAFTLRTVA
DLEPRVTELAGRLLEKVEGSEFDLVGDFAYPLPVIVIAELLGVPAEDRELFRGWSDRM
LSMQVDDPLEIQFGDEAGEDYERLVKEPLKEMHAYLQRHVDARRETPGDDLLSRLVTA
EIAGERLTDRQIVEFGALLLMAGHVSTSMLLGNTVLCLEENPETAAALRADRALISGV
IEEVLRMRPPITVAARVTTGEVVVGGVTIPKDRMVMASLLSANHDERHIQDPEVFDPR
RSPNPQLAFGHGIHYCLGGPLARLEGRVALEMLLDRFEDIRVTPGAPYDFHREGLFVP
ARSPLTVRRG

CYP113D1 Saccharopolyspora erythraea NRRL23338

MSIPADTWGIPASQFWLRGRRPERTVDYDAATGMWNVYGYPEIQHVLSDPRTFSSDTTRL
MPAKVAERTSALSEGSLLQMDPPEHTKLRKLVSHAFTPKVVADLAPRIADLANELLDDVG
DRMEMVEDLAYPLPVIVIAELLGVPGSDRHLFKKWVDALLQRDQQFSLVDESDEQVQQVE
EAIAQVKHLTDYLGEHAAERRRAPREDLLTKLVQAEVDGHRLSDTEVVNFANILLLAGHI
TTTMLLGNTVLCLDTHPRQRDAVRADRSLVPSAIEESLRFFSPFAVLGRVTQREVEVGGQ
TIPQDQMLMLWIAAANRDPRQFADPDVFDVTRDPNPQIAFGRGIHFCVGAPLARLEGKVA
LNILLDRFPHLRTDPDEGPTFLPAPTTTGVRKLPLLLTPSA

CYP113E1 Salinispora tropica (marine actinomycete)

MATVPRLTFADGGVSVLPWFRQMRDDQPVWYDQGTGSWNVFRYADIAQILTDPATFSSDP
GRTMPPELVEEAEGSLVAVDPPRHGRLRALISTAFTPRLVEQLAPRVRSIAERLLDRTFV
DRGPEGEFDAIGDVAYLLPVYVIGELLGLPETDREYLVRTADEFYAISADDPFDGTYMAS
MQSTLDGLGTYMLDQAERRRARPGDDLMSALAHAEIDGEQLNDREIRNFAVLLLTAGHIT
TTALLGNTLLALGERRDVMLRWRHGQVDTADVLEEVLRHRTPFTEVYRFTTTEVTIGNQV
VPGDQLLRLWIASGNRDERQFADPDTFVLGRDSRHLGFGLGIHYCLGASLARMESSVVLE
VLAERTTTLAPAVQGLSYYDAPGIFCLRSLPVSYRRS

CYP113F1 Streptomyces sp. Tu6071

ABB69748
PlaO3
1 MTASEEGTRL ADQSADAATM LAWFRRMRES EPVSHDEEAG VWHVFRHADV ERVLADPGTF
61 SSDFSSFMPA QEDVDRFIKG NLLRKDPPQH RKLRTLVSKA FTPGVVARLA PRIEVIADEL
121 LDAKAGADQL ELVADLASPL PVTVIAELLG IPAEDRPMFG RWADSLVAPE SQTSFIPNED
181 RTKAMAVVMR EMNAYCLEHI RRRRAAPSQD LVSKLVAAEV DGQRLDDDEI IGFVGLLLLA
241 GHITTTALLT NVILCLDEFP DIAAALRADP SALPGAIEEV LRFRTPLAPS MRRTTREVRV
301 GEHTVPAGRI LLAWLASANR DERQFTAPDT FDIHRAPNPH LSLGHGIHFC LGAPLARLEV
361 RIAVEKMLGR WSGITVADGV ECHDARGIVG AKKLPLRLRW A

CYP113F2 Frankia sp. EAN1pec

MSQLTTRPNAVRRSLPDLLRWLDELRRRGQVHRDDRQRCWHVLGHPEAGAVLADHRSFTSDLRGLLPRPE
DMPEYNLQEGSFQEDMELFQRGNFVRLDPPEHHRLRGLASRAFTSRTVAGLAPRIAEVTTELLDATGGRT
RLELIDDLAYPLPVIVIAELLGLPAADRPMFRGWADALFDREVADPDQPLTELAAANTRAAVPVLREMNA
YLLDRIRACRAHPGDDLTGRLVQVEVDGQRLADEEIVGFVGLLLLAGHITTTATLGNAALALDEHPGAAA
ELRAEPELLPATIEEVLRLRTPFPRLVRRAVADTRVGDEVIPAGAVVTVWLTAANRDERVFAEPDRFDPR
RAPNPHIAFGQGIHFCLGAPLARLEARTALGILLDRYSDIAVAADVPVEHRDPWAMVSVNSLPLDVRPR

CYP113G1 SBI_3232 Streptomyces bingchengensis

47% to CYP113C1 Streptomyces virginiae
MSEQAISLTPPSAADGGATLFGWLRRMREESPVVQDNNGSWYVFRHADVQ
HVLTEYADFSSDPTPISPKAAEIAKGDLAQIDPPEHHGLRRQISRVFTPR
MVAELEPRIEEIGRLLLDEAGDAGELDLVRQLTHPLPVIVIAEMLGVPAE
DRPVFRHWADRIIAAKIAGIDDPETYERLRSAIEEMDFYLEGQLDERRSR
PGDDLLSKMVTAEVDGDPISGAEAVNFARLLLVAGHITTTMMLSSSILCF
DEYPEAAREVREDRSLLPAAIEEVMRYRPPFTITGRYTTRDVELSGVTIP
ERSVVIPWLASANRDERRFMDPDVFDIHRSPNPHVAFGKGIHFCIGAPLA
RLEGKVALNLLFDRYSDVRIDRDASLEFYEHNFFGVKSLPVSVKHA

CYP114A1 Bradyrhizobium japonicum

MLSRHADIFWAFKATGDAFRGPAPGELARYFSRAATSPSLNLLA
STLAMKDPPTHTRLRRLISRDFTMGQIDNLRPSIARIVAARLDGITPALERGEAVDLH
REFALALPMLVFAELFGMPQDDMFELAAGIGTILEGLGPHASDPQLAAADAASARVQA
YFGDLIQRKRTDPRRDIVSMLVGAHDDDADTLSDAELISMLWGMLLGGFVTTAASIDH
AVLAMLAYPEQRHWLQADAARVRAFVEEVLRCDAPAMFSSIPRIAQRDIELGGVVIPK
NADVRVLIASGNRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQL
ARVQLAESLPRIQARFPTLAFAGQPTREPSAFLRTFRTLPVRLHAQGS

CYP114A2 Rhizobium sp. NGR234 plasmid pNGR234.

MDMQETTTACADAFAELASPACIDDPYPFMRWLREHDPVHRAAS
GLFLLSRHADICWALKATGDAFRGPAPGELARYFPRAATSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTMREIDNLRPSIARFVAARLDGMAPALERGEAVDLHRQFALALPMLV
FAELFGMPQDDMFGLAAGIGAILEGLSPHASDPQLAAADAASARMKAYFGDLIQRKCI
DPRHDIVATLVGAHDDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPDQ
RHWLQGDAAGVEAFVEEVLRCDAPAMFSSIPRIAQSDIELSGVVIPKNADVRVLIAAG
NRDPDAFADPDRFDPARFYGTSPGMSTDGKIMLSFGHGIHFCLGAQLARVQLAESLPR
IQARFPTLTVAEQPTREPSAFLRTFRALPVRLHAQGDSPRLTSAFLNGQRGVEGGASF
EHGDGERRSATDRRAQP

CYP114A3v1 Mesorhizobium loti

1 MDVQETTAAC RDAFAELASP ACIQDPYTFM RWLREHDPVH RAASGLFLLS RHADIYWALK
61 ATGDVFRGPA PGELARYFPR AETSLSLNLL ASTLAMKEPP THTRLRRLIS RDFTIRQIDN
121 LRPSIARIVA ARLDGMAPAL ERGEAVDLHW EFALAVPILV FAELFGMPQD DMFGLAAGIG
181 AILEGLSPHA SDPQLAEADA ASARVQAYFG DLIQRKRTDP RNDIVSMVVG AHDDDADTLS
241 DAELISMLWG MLLGGFATTA ATIDHAVLAM LAYPEQRHWL QGDAVGVKAF VEEVLRCDAP
301 AMFSSIPRIA QRDIELGGVV IPKNADVRVL IAAGNRDPDA FSDPDRFDPA RFYGTTPGMS
361 TDGKIMLSFG HGIHFCLGAQ LARVQLAESL PRIEARFPTL ALAEQPTREP SAFLRTFRAL
421 PVRLHAQGG

CYP114A3v2 Mesorhizobium loti

GenEMBL AL672112 complement(84020..85309)
Strain R7A symbiosis island
Gene = msi070
10 DIFFS with CYP114A3v1

CYP114A4 Rhizobium etli symbiotic plasmid p42d

MDVQDTTAACHDAFAELASPACIQDPYPFMRWLREHDPVHRAAS
GLFLLSRHADIYWAFKATGDAFRGPAPSELARYFPRAASSLSLNLLASTLAMKEPPTH
TRLRRLISRDFTVGQIDNLRPSIARIVAARLDGMAPALERGEAVDLHREFALALPMLV
FAELFGMPQDDVFELSAIVSAILEGLSPHASDPQLAAADVASARVKAYFGDLILRKRA
DPRRDIVSTLVGAHTDDADTLSDAELISMLWGMLLGGFATTAATIDHAVLAMLAYPEE
RHWLQGDAAGVEAFVEEVLRCEAPAMFSSIPRIAQRDIELHGVVIPKDADVRVLIAAG
NRDPDAFADPDRFDPVRFYGTRPGMSSDGKIMLSFGHGIHFCLGAQLARVQLAESLPQ
IQARFPTLALAEQPTREPSAFLRTFRALPVRLHAQAAAEVRVVVDQDLCGTTGQCVLT
LPGTFRQREPDGVAEVCMATVPQALHAAVRLAASQCPVAAIRVIESEAGDDHCTNPGP
TPSPADAERHAAKDLRNPGEHDGTI

CYP115A1P Bradyrhizobium japonicum

1 MADTSGARSN LLHQSVRSIY
GDADRFDVTR RHNPHLSFGQ GPHFCLGAAL ARLELGCAFP
61 ALFVRLEHLA LTIAAEDVVY MPSYVIRCPQ RLPVTFRPSI A

CYP115A2v1 Mesorhizobium loti

1 MPAAPTQLDR LSSAILRQGG MARVSLPGDV VTWAAARHQT LRQMLSDQRF NKDWRQWRAL
61 QDGEIPEDHP LIGICKVDNM TTAHGADHRR LRGLLSSSFA PSRIALLAPR VEQCVDRLLA
121 EMAQRGGSAD LMSEFAAPLP TNVIAELFGL PDEQREEIVA LTYSLASTSA TAEEVRQTRQ
181 RIPEFFRRLI ALKRGQLGDD LASALIVARD KGELVSDTEL IDMLFMVLSA GFVTTAGVIG
241 NGVLALLTHP QQLHLVRSGQ VPWSQAIEEI LRWGTSAANL PFRYATQDVE IDGCLVRRGD
301 AVLMAFHAAN RDEKAFGPGA NRFDVTRRHN PHLSFGEGPH SCLGAALARL ELRCAFPPLF
361 GRLEDLALTI AAEDVVYMPS YVIRCPQRLP VSFRPSVA

CYP115A2v2 Mesorhizobium loti

GenEMBL AL672113 41375..42607
Strain R7A symbiosis island
Gene = msi159
10 DIFFS with CYP115A2v1

CYP115A3P Rhizobium etli symbiotic plasmid p42d

ANSYGRPTYGDTDMFDFNRLQNPHLPLGQGPHLCLGAALARLELGSVFPPPFVRPEDLALAIAAE

CYP116A1 Rhodococcus erythropolis

MTVDHAPEGVKSPTGCPVSGMAADFDPFRGAYQVDPSSSLRQAR
KDEPVFFSPLLDYWVVTRYEDIKQIFKTPSVFSPSITVDQITPISDEALQILGSYQFA
AGRMLVNEDEPIHTERRRLLMQPFEADNVATLEPKIREVVNTYLDRVIKDGRADLIGD
LLYEVPCIVALIFLGVPDEDIETCRQYGMQQTLFTWGHPTGDEQTRVATGMGKFWEFA
GGLVDKLKADPNAKGWIPHAIEMQRQHPDLFDDNYLQNIMFGGVFAAHETTTNATGNA
FRTLLENRSSWDEICADPTLIPKAIEECLRYSGSVVAWRRKAVVDTTVGEVDIPAGGR
LLIVMASANRDDSMFPEPDDFDIHRGNAQRHLTFGIGSHTCLGATLARLEMKVFLEEV
SRRLPHMSLVAGQEFSYLPNTSFRGPEHVLVEWDPQQNPVPADRP”

CYP116A2 Saccharopolyspora erythraea NRRL23338

VEELQVDATRVGAGCPISRIAEEFDPFGEAYQQDPAGVLKAAREREPVFYSPELDHWVVT
RYADIKEIFRDTRRFSASNALDPITPLGAKARERLAEYDFAPGPVLVNEDEPLHMRRRRA
LAGPLAADEVAKLEGRIRDLVTRYVDGFAGRGRADLVDDLLWEVPAIVGLLVCGVPDEDI
DRARHYTIKMGSFTWGRPTEEHQVEIADQVGQWWSLSGRLVERLKREGGEGWVPTAIEVH
REDPELVNDNHLQNMMMSGLVAAHETTTNATANALRHLLSNRSSWEALCADPSAIPNAVE
ECLRFSSSVLCWRRKALVDVPVGGVTIPAGARVLLVIGSGNHDDDVFGDPGELDIARSNA
KRHLTFGIGSHACIGAPLARLEMRIILEELTRRLPGMRLVEGQDFGYLRNASFHGPRHLL
VEWEPAGA

CYP116B1 Ralstonia metallidurans

MPQTNAPASSGSCPIDHSALRAPNGCPISHQAAAFDPFEDGYQQ
DPPEYVRWSRAQEPVFYSPKLGYWVVTRYDDIKAIFRDNITFSPSIALEKITPTGEAA
NAVLASYGYAMNRTLVNEDEPAHMPRRRALMEPFTPAELAHHEPMVRKLTREYVDRFI
DTGRADLVDEMLWEVPLTVALHFLGVPEEDMDLLRQYSIAHTVNTWGRPKPEEQVAVA
HAVGNFWQLAGRILDKMREDPSGPGWMQYGLRKQRELPEVVTDSYLHSMMMAGIVAAH
ETTANASANAIKLLLQHPDVWREICEDPALIPNAVEECLRHNGSVAAWRRLVTRDTEV
GGMSLAAGSKLLIVTSSANHDEHHFADADLFDIHRDNASDQLTFGYGSHQCMGKNLAR
MEMQIFLEELTSRLPHMRLAGQRFTYVPNTSFRGPEHLWVEWDPARNPERTDPTVLAP
RDAVRIGEPTGGTTGRTLIVERVETAAQGVSRIRLVSPDGRALPRWSPGSHIDIECGH
TGISRQYSLCGDPADTSAFEIAVLREPESRGGSAWIHASLRAGDKLKVRGPRNHFRLD
ETCRRAIFIAGGIGVTPVSAMARRAKELGVDYTFHYCGRSRASMAMIDELRALHGDRV
RIHAADEGQRADLAQVLGAPDANTQIYACGPARMIEALEALCATWPEDSLRVEHFSSK
LGTLDPSREQPFAVELKDSGLTLEVPPDQTLLATLRAANIDVQSDCEEGLCGSCEVRV
LAGEIDHRDVVLTRGERDANNRMMACCSRAAKGGKIVLGL

CYP116B2 Rhodococcus sp. NCIMB 9784

MSASVPASAPACPVDHAALAGGCPVSANAAAFDPFGSAYQTDPA
ESLRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNILFSPAIALEKITPVSAEATAT
LARYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESG
KADLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAV
GRFWQYAGTVLEKMRQDPSGHGWMPYGIRKQREMPDVVTDSYLHSMMMAGIVAAHETT
ANASANAFKLLLENRAVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATADTRIGDV
DIPAGAKLLVVNASANHDERHFERPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEM
QIFLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLHRHQ
PVTIGEPAARAVSRTVTVERLDRIADDVLRLVLRDAGGKTLPTWTPGAHIDLDLGALS
RQYSLCGAPDAPSYEIAVHLDPESRGGSRYIHEQLEVGSPLRMRGPRNHFALDPGAEH
YVFVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSE
EGTRIDLAALLAEPAPGVQIYACGPGRLLAGLEDASRNWPDGALHVEHFTSSLAALDP
DVEHAFDLELRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVAVLDGEVD
HRDTVLTKAERAANRQMMTCCSRACGDRLALRL

CYP116B3 Rhodococcus ruber

MSASVPASACPVDHAALAGGCPVSTNAAAFDPFGPAYQADPAES
LRWSRDEEPVFYSPELGYWVVTRYEDVKAVFRDNLVFSPAIALEKITPVSEEATATLA
RYDYAMARTLVNEDEPAHMPRRRALMDPFTPKELAHHEAMVRRLTREYVDRFVESGKA
DLVDEMLWEVPLTVALHFLGVPEEDMATMRKYSIAHTVNTWGRPAPEEQVAVAEAVGR
FWQYAGTVLEKMRQDPSGHGWMPYGIRMQQQMPDVVTDSYLHSMMMAGIVAAHETTAN
ASANAFKLLLENRPVWEEICADPSLIPNAVEECLRHSGSVAAWRRVATTDTRIGDVDI
PAGAKLLVVNASANHDERHFDRPDEFDIRRPNSSDHLTFGYGSHQCMGKNLARMEMQI
FLEELTTRLPHMELVPDQEFTYLPNTSFRGPDHVWVQWDPQANPERTDPAVLQRQHPV
TIGEPSTRSVSRTVTVERLDRIVDDVLRVVLRAPAGNALPAWTPGAHIDVDLGALSRQ
YSLCGAPDAPTYEIAVLLDPESRGGSRYVHEQLRVGGSLRIRGPRNHFALDPDAEHYV
FVAGGIGITPVLAMADHARARGWSYELHYCGRNRSGMAYLERVAGHGDRAALHVSAEG
TRVDLAALLATPVSGTQIYACGPGRLLAGLEDASRHWPDGALHVEHFTSSLTALDPDV
EHAFDLDLRDSGLTVRVEPTQTVLDALRANNIDVPSDCEEGLCGSCEVTVLEGEVDHR
DTVLTKAERAANRQMMTCCSRACGDRLTLRL

CYP116C1 Rhodococcus sp. RHA1 Rha08932

MTETTPAPNAEDIVAGKCPVSHFAAEFNPFDEEYQQDPYPVFKSVREQEPVFYSPEIDYWIVSRYEDIIEIFKDTESYSASEAGVMITPPCPAAMDVLAEANFVPSTMLVDEDAPLHPKRRRVFRKGLNDNKVAELEPYTRRFVSECLDTIVKNGRADMVGDMTFSVPALTAFILMGVPE
AEVERVRGYAARFALWLWGRPTDEQQVALAGDYAAYLQYAREHVDKLAENPGEDYMSNVIKAWQKDGNDEVWDKTYLASIMQSHLYASHETTTNAAASGIKSLLENRDQWDAICADPSLIPGAVHEILRYQSSVPTWRRITTRPVRLGGYDLPAGSRVMMLTGSANHDDAKFE
DGESFDITRENADEHLAFGWGVHLCLGQGLARMEMRVMLEETTKRLPHLRLVEDQEWTYSPNTSFRGPDHVRVEWDASQNPLPEDRP

CYP116C2 Rhodococcus sp. RHA1 Rha10704

MTETSAEPHRSQGAGKCPVSHIAAEFNPFADDYLQDPYAVFTRARAEEPVFFSPSLGYWVVSRHEDVRQVFQDPAFSASISITPLKELCPAAVDELVKAEMVMGPSLVNEDPPLHTKRRRLIQKAMISPARIEAVTPRIRALTTSYIDGFVRRGHADLVADFAWEIPALVAFALMGVPDE
DVERAKEFAGRLALFTWGYPSEEEQRKLAAGMGQYWIYAKEHVKRRLEDPTDDYISNLIAAWRKPGNEDLFDENYLVTTMMNFLFAGHETTTNATANGLRALLEHRDQWAALCADPSLVPGAVEEILRFSSSVVAWRREATEDTHIGDVPIPAQAKVLVLTGSANHDEEVFPEPER
FDITRTNADEHLAFGFGRHLCLGAPLARIEMGIFLEELTRRLPHMQLAEGQTFTYSPNTSFRGPDHLFVGWDPSQNPVPEDRP

CYP116D1 Saccharopolyspora erythraea NRRL23338

MHERFDPLATDYLADPFPILAAIREETPVFYSSELDMWPVTRHEDIKRIFTDYETFSGAI
TQTPVYPLAEEAKDILAAGFHTTPTVSNCDPPKHTRVRAHNVKAFSARRIAVLEPTIRAY
VTEMIDRILHQDRFDIVQEVTFPLPATIVFNLIGFPESDMEMLKGLAINRMAFTWGRSTE
AEQVRIAKNQVDYWQYCTEFVASRLAEPKDDFTSDLIRTHLADPDELSVDEITNVVHALS
FAGHETTTNVSSSMIQRLLTHREQWEELCADPALIPKAIEEGLRFDPSLFTWRRITTKPV
SIGGVEVPAGAKLLLLVGSANHDPAKFPDPEAFNIHRSGAQAHLTFGRGIHSCFGAPLAR
LEMQIMLEELTARMPGLRLVEDQDVQYHVNACFRGPVELWLDNSAHR

CYP117A1 Bradyrhizobium japonicum

MFGGTLVAQDGIAHRQARDAIQAALLPKGLTLAGIGELFAPVIR
ARVQRWRERGDVTILRETGDLMLKLIFSLMGIPAQDLPGWHRKYRQLLQLIVAPPVDL
PGLPLRRGRAARDWIDARLREFVRAAREHASRTGLINDMVSAFDRSDDALSDDVLVAN
IRLLLLGGHDTTASTMAWMVIELARQPGLWDALVEEAQRVGAVPTRHADLAQCPVAEA
LFRETLRVHPATPLLVRRALRELRIGQQRIPTGTDLCIPLLHFSTSALLHEAPDQFRL
ARWLQRTEPIRPVDMLQFGTGPHFCMGYHLVWLELVQFCIALALTMHEAGVRPRLLSG
VEKGRRYYPTAHPSMTIRIGFS

CYP117A2 Rhizobium sp. NGR234 plasmid pNGR234a

MNVLLNPLNRRHRLRYDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCVDPHAFALLRHKDVSSALIEEIAPELLGGTLVAQDG
GAHRQARDAIKAAFLPEGLTQAGIGDLFAPVIRARVQAWRDRGDVTILPETGDLMLKL
IFTLMGVPAQDLPGWHRKYRQLLQLIVAPSVDLPGLPLRRGRAARDWIDAQLRQFVRD
ARAHAARTGLINDMVSAFDRSDDALSDDLLVANIRLLLLAGHDTTASTMAWMVIELAR
QPMLWDALVEEAQRVGAVPTRHADLEQCPVAEALFRETLRVHPATTLLPRRALQELQL
GQRRIPAGTHLCIPLLHFSTSALLHEAPDQFRLARWLQRTEPIRPVDMLQFGTGPHVC
IGYHLVWLELVQFSIALALTMHKAGVRPLLLSGVEKGRRYYPTAHPSMTIRIGFS

CYP117A3 Mesorhizobium loti

1 MDMLLNPLDR RHRLRDDIPV VPGAFPLVGH LPAIVCDLPR LLRRAERTLG SHFWLDFGPA
61 GHLMTCVDPD AFALLRHKDV SSALIEEIAP ELLGGTLVAQ DGGAHRQARD AIKAAFLPKG
121 LTQAGIGNLF APVIQARVQA WRDRGDVTIL RETGDLMLKL IFSLMGIPAQ DLPGWHRKYR
181 QLLQLIVAPP VDLPGLPLRR GRAARDWIDA QLRQFVRDAR AHAARTGLIN DMVSSFDRGD
241 DALSDDVLVA NIRLLLLAGH DTTASTMAWM VIELARQPGL WDALVEEAQR VGAVPTRHAD
301 LAQCPVAEAL FRETLRVHPA TTLLPRRALQ ELQLGQRRIP AGTPLCIPLL HFSTSALLHE
361 APDQFRLARW LQRTEPIRPV DMLQFGTGPH VCIGYHLVWL EMVQFCIALA LTMHKAGVRP
421 RLLSAVEKGR RYFPTAHPSM KIRIGFS

CYP117A3v2 Mesorhizobium loti

GenEMBL AL672112 complement(81551..82888)
Strain R7A symbiosis island
Gene = msi068
2 DIFFS with CYP117A3v1

CYP117A4 Rhizobium etli symbiotic plasmid p42d

MDMLLNPLNRWRRLRDDIPVMPGAFPLVGHLPAIVCDLPRLLRR
AERTLGSHFWLDFGPAGHLMTCLDPDALALLRHKEVSSALIEEMAPDILGGTLVTLDG
SAHRQARDGIKAAFLPRGLTEAGIGELFEPIIRAQVKAWRDRGEVAILPDTRNLMLKL
TFSLMGIPAQDLSEWHRKYRQLLQLMVAPPIDLPGMPLRRGRAARDWIDAQSRQFIRD
ARARAARTGLINDMVSAFDCSDGALSDDVLVANIRLLLLAGHETSASTIAWMVIELAQ
HPELWDALVEEAQRVGAVPTGHEDLAQCPVAEALFRETLRMHPASSLVPRRAMQELQL
GQRRIPSGTHLCIPLLHFSTSPLLHEAPDQFRLGRWLQRTEPIRPVDMLQFGAGPHVC
MGYHLVWLELVQFSIALALTMQEAGVRPRLMSGVEKGRRYYPTAHPSMTVRIGFS

CYP117B1 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_5081

MTTALPASFA DLPLLQGRNP LARRIETRHG FPILPGRFPV VGHMPAIAVD ELGLLREGQR
RFGSLFFWAP GVDAWQLIYA SNEAFSLFKS KAVDSSYLTE GGVGHLFGQT LMAHDGASHR
RLRTAMNGPF SPKGLDAAEV GAIVATSVER KVRSWLGRRD VQLLRETREL ALEVMFKITG
VEDDELPEWR HYYEDLMLVI LSLPFDVPGS PRRRGLRARA WLDERIGRIL AGVRARGDAK
GLLPALLTAR DEQGEPLSEQ DLVGNLRLLL LAGHETSASV MAWCVAHLAE SPAVWRALRE
EASSAPDLPR SPADLRRFPF AEAVFREALR LHPPVPHDAR RAVADFELDG RAVPAGTHVA
IPLVLLSRDP ELYPDPDSYR PERWLGRKEA LSPLEIAQFG GGAHFCLGYH LAWMEIVQFL
VALGRELPAS GPRLQGGFPA SRYLPVLRPS GGTRVRFDG

CYP118P1/CYP102 PSEUDOGENE Mycobacterium leprae

RLGSGIVEQRISVLSIIALADPXXXXXXXDETVWENI
XXXXXXRLLMGDELFTXXXXESNWGKAHN
TASQHDDILDIMLYSADPSTGEQLDTDNVVNQILTLLVSGSQTLANAIAFALHYLLSIHH
DIAAQTRREIYQNRSDRGIANVSY
FGDVVKLRCLRRVVDATLRLWS
VPCYLRQARRD
TTLGNGTSLFHKGQWVIVLLTAPMPG
WGPDANEFNPDRVLPEICRKLPYTYIL
FGTGLRTCIGRRFALHEMALELTMIVHQYILSRADPG
YCLSISEAFTLKTVGL

CYP119A1 Sulfolobus solfataricus (an archaebacterium)

MYDWFSEMRKKDPVYYDGNIWQVFSYRYTKEVLNNFSKFSSDLT
GYHERLEDLRNGKIRFDIPTRYTMLTSDPPLHDELRSMSADIFSPQKLQTLETFIRET
TRSLLDSIDPREDDIVKKLAVPLPIIVISKILGLPIEDKEKFKEWSDLVAFRLGKPGE
IFELGKKYLELIGYVKDHLNSGTEVVSRVVNSNLSDIEKLGYIILLLIAGNETTTNLI
SNSVIDFTRFNLWQRIREENLYLKAIEEALRYSPPVMRTVRKTKERVKLGDQTIEEGE
YVRVWIASANRDEEVFHDGEKFIPDRNPNPHLSFGSGIHLCLGAPLARLEARIAIEEF
SKRFRHIEILDTEKVPNEVLNGYKRLVVRLKSNE

CYP119A2 Sulfolobus tokodaii

GenPept BAB66184
64% to CYP119A1 U51337 Sulfolobus solfataricus
1 MYDWFKQMRK ESPVYYDGKV WNLFKYEDCK MVLNDHKRFS SNLTGYNDKL EMLRSGKVFF
61 DIPTRYTMLT SDPPLHDELR NLTADAFNPS NLPVDFVREV TVKLLSELDE EFDVIESFAI
121 PLPILVISKM LGINPDVKKV KDWSDLVALR LGRADEIFSI GRKYLELISF SKKELDSRKG
181 KEIVDLTGKI ANSNLSELEK EGYFILLMIA GNETTTNLIG NAIEDFTLYN SWDYVREKGA
241 LKAVEEALRF SPPVMRTIRV TKEKVKIRDQ VIDEGELVRV WIASANRDEE VFKDPDSFIP
301 DRTPNPHLSF GSGIHLCLGA PLARLEARIA LEEFAKKFRV KEIVKKEKID NEVLNGYRKL
361 VVRVERA

CYP120A1 Synechocystis sp. (strain PCC6803) Cyanobacterium

MITSPTNLNSLPIPPGDFGLPWLGETLNFLNDGDFGKKRQQQFG
PIFKTRLFGKNVIFISGALANRFLFTKEQETFQATWPLSTRILLGPNALATQMGEIHR
SRRKILYQAFLPRTLDSYLPKMDGIVQGYLEQWGKANEVIWYPQLRRMTFDVAATLFM
GEKVSQNPQLFPWFETYIQGLFSLPIPLPNTLFGKSQRARALLLAELEKIIKARQQQP
PSEEDALGILLAARDDNNQPLSLPELKDQILLLLFAGHETLTSALSSFCLLLGQHSDI
RERVRQEQNKLQLSQELTAETLKKMPYLDQVLQEVLRLIPPVGGGFRELIQDCQFQGF
HFPKGWLVSYQISQTHADPDLYPDPEKFDPERFTPDGSATHNPPFAHVPFGGGLRECL
GKEFARLEMKLFATRLIQQFDWTLLPGQNLELVVTPSPRPKDNLRVKLHSLM

CYP120A2 Trichodesmium erythraeum

MTANYLEKWVEMGTLTWYPEIRNYTFDIASLLFMGSDESSQTKL
VSLFEEWVKGLFSIPLSLPWTRFGKSLRCRQKLLQHIEEIILQRQQQQNLGEDALGIL
LQAQDKEVNGLSLDELKDQILLLLFAGHETLTSAIASFCLLTSQHLDVLTRLRQEQKQ
FSAIEPLTLENLKRMTYLDMVLKEVLRLIPPVGGGFRQVTQDCEFCGYSIPKGWLVQY
QIAKTHQDETLYPDDKNFDPERFAPENAVDKQKVFGYVPFGGGMRECLGKEFARLEMK
IFAVMLLRGYEWELLPEQDLSVVAAPTPYPRDGLKVKFRKVE

CYP120A3 gi|126659238|ref|ZP_01730375.1| cytochrome P450 [Cyanothece sp. CCY0110]

54% to CYP120A1
MLIFFFYNKSKLIYNFDQKMTNIESQKSVSLPPGETGLPFIGETLSFLFDPDFAKKKKSKYGQIYKTNIF
GNDTVTMIGAEANQFLFRNENKYVVSTWPKSTRVLLGKLSLAVKDGNFHTSRRKLLAQAFQPRALNSYIP
KMTEITQQYVEKWLQTKELTWYPELRKYTFDVACSLLISIDNASQTKLASDFETWCQGLFTLPINLPWTN
FGKALKCRAKLLQEIETIIINRQQQPKHQNDALGILLEAKDEEGNSLTIEELKDQILLLLFAGHETLTSS
LSSFVLLMAQHPNILEKVRTEQENLNITEDITSEKLKEMTYLEEVLKEVLRFIPPVGGGFRKVIEEFEFQ
GYRIPKDWTVQYQIAQTHKESDIFPDYQTFDPERFSPENMADKQKNFGYIPFGGGLRECLGKEFARLEMK
IFASVLVHNCHWQLLPDQDLEMITIPSPRPRDGLKVKITEV

CYP120A4 gi|119485417|ref|ZP_01619745.1| cytochrome P450 [Lyngbya sp. PCC 8106]

53% to CYP120A1
MTTSEKKQSYPTPPGSLGLPLIGETLSFLRDRDFATKRHQKYGSVFKTNIFGNPTIMMIGTEANQFIFTN
EKKYFENSWPPSTTALLGPASLTIQTGDIHKSRRKLLAQAFQPRVLAGYVPTMEIMTRRYLQKWEQQKTF
AWYPELRKYTFDVACKLFVGDEKASETEMGEWFETWCQGLFTLPLRLPGTKFNKALNCRKKLLNQIETII
RQRQQQAEPGEDALGLLLQAKDEDGNSLSVEELKDQILTLLFAGHETLTSSVTAFCFLLAQHPDVLAKAR
LEQQQIQLTEPLSFEQLKLMSYLDQVLKEVLRFIPPVGGAFREVIETCEFNGYTFPKGWTVLYQIGKTHQ
DNSIYNQPEKFDPDRFSPERTEEKPYGYIPFGGGMRECLGKEFAKLEMKVLATMLLREYEWELLPNQNLE
MTVSPTPHPKDELLVNFKRLSEVH

CYP120A5 gi|119509406|ref|ZP_01628555.1| cytochrome P450 [Nodularia spumigena CCY9414]

53% to CYP120A1
METTNSQTQNKLPLPPGNLGLPLIGETISFLRDPEFAEQRYQQYGPIFKTHLFGQPTIMMIGAEANRFLF
SNENQNFTISWPDSTKTLLGPASLALQTGGTHQKRRKLLSQAFQPRALAGYTSKMEEITHNYLHKWQRMG
TFKWYPELRNYTFDVACKLLIGTDAASDSHFGELFEEWCAGLFTIPINLPWTKFGRALRCRQQLLVKIEE
IILQRQQQPHSDADALGLLLQAEDEDGNRLSLAELKDQVLLLLFAGHETLTSAIASFCLQLAQHPEVLAQ
ALAEQQQLAIEESLTLEHLKQMQYLDQVLKEVLRTIPPVGGGFRRVIQSSEFNGYQIPEGWSVLYQIGKT
HQDSSTYTEPESFDPQRFAPERVEDKQKPFGYVPFGGGVRECLGKEFAKLEMKLFAALLIREYHWELVPG
QNLDLIMVPTPHPRDDLQVNFSTQRGAEGSAKVRGVLDLGGEVAM

CYP120A6 ORF00071 [Synechococcus sp.PCC7002]

53% to CYP120A1
MTSPSELPLPPGKFGLPVIGETIEFFTDRNFQKKRLEKYGDVFKTSIFTKPTVVMVGAEA
NEVLFRNENKYVKATWPKSTRILLGADSLATQEGGIHSSRRRIIFQAFQPRALESYIPTI
EKITQRYLTQWEQKQEFAWYDELRKYTFDVASTLFIGKDGGAETPLANLFEEWVKGLFSL
PINLPWTAFGKAMKCRRKLLRELEMIIGDRLKTYDANAEPTDALDLLIRAKDEDGNSLSI
DELKDQILLLLFAGHETLTSSLVSFGLLVGQHRDVFEKIRAEQDALDIGNGLDMAVLQQM
TYLDQVFKEVLRLVPPVGGGFREVINTFEYKNFQIPQGWAVQYQIAQTHKDEALYPDHEK
FDPERFSPERLADKQKKFGFIPFGGGMRECIGKEFARLEAKILASMLARDYDWELLPDQD
LSMQVIPTPLPKDGLQIRFYRRQESSSTTA

CYP120B1 Nostoc punctiforme

MKTNQIPPGSFGLPVLGETLSFVFDRDFAKKRYHQYGPIFKTHL
LGRPTVVMAGPEALEFVLSSHIENFSWREGWPDNFKTLLGESLFLQDGEEHRRNRRLM
MPALHGPALASYFSTMEDITRSYLQKWEKKQEFTWFQEFKQLTFDIASQLFLGTRPGP
ECVRLSQLFTTLTNGLLAINPLPLPFTTFGKAIAARNEILEHLTQVVRERQQNPTQDT
ISLLIKAKDEDGNSLSEKEIIAQAVLLLFAGHETTTSMLTWLCTELACHPEVLEKARV
EQLQLASQGDLDLEQLGKMPYLEQVLWEVERLHQPVGGGFRGVIKDFELNGYHVPTGW
QLYYSIGVTHQIEEIYSEPELFDPDRFSPQRQEHKKYPFSLVGFGGGPRICIGIAFAK
MEMKIVAAHLLRSYHWEILPNQSLEVVAVPTNRPKDGLRVRFQPR

CYP120C1 Nostoc punctiforme

MQQLKSAEEIPGSYGLPILGETLEIFRDSELYLWRRFQQYGSVF
KTSVLGRKRAYLIGPSANRLVLVEQAENMSSRIGWYFLESTFGNNILLQDGEEHRLTR
RLMYPAFHGKAIATYFDTIQNIVQDFLKDWGERGTISLNSSFRQLTLMIATRLFLGSQ
NKSEVEQTSQWFTQLLDSSMAIFKWNVPFTLYGRGQNARGKLVAFLREAIAQRIEQGN
LEESKDVLGLLLAAVDEDGNKLSETQVINEALLLLFAGHETTASLLTWVIFELGNHPE
WRERLRQEQLAVVGNNPLSLSHLKQFPQLTNVLKEAERLYPPVYAYNRGVLKDIEYGG
YRIPAGWFVTISPMLTHRLPELYTEPDRFDPDRFAPPREEDKKHPLALMGFGYGSHSC
LGMEFAQMEMKIVLSTLLRHYDWTVKPDYSAIAPVRQPSKVKDILQAYIEPLLIKHPL
DS

CYP120D1 gi|126661226|ref|ZP_01732300.1| cytochrome P450 [Cyanothece sp. CCY0110]

48% to CYP120A1
MLFGNSSISVQVGEIHKQRRQILYEVFKPRMLDSYFNTMVKITEKYLDYWMKQENIVWYPEIENYTFDLA
FKFLIGLDKASESSFKPLYEQWQKGIFSLNTIKLPWTKFGKAWKARNLLKKELKEIIIKRQKEQEANDSD
ALDILIKAKDEDGKQLLVDEISDHLLNILFAGYGTLTSTLASFCRLMAQEGEILGKIREEQQRFPKQLTI
MQLKEMPYLDLVLKELLRTNTPVGTGFRQTINNCEINGYHIPKNWFIFYQISNTHKDTDIYQDPDVFDPD
RFGLDRAEGEKPFSYLPFGGGIRECLGKDFARLEMKIFSSLLVRKCQWDLLPNQNLEIEFTPVAKPKDGL
KVKISSY

CYP120E1 gi|113476367| YP_722428 Trichodesmium erythraeum IMS101

MNMNFKSSNPASSLALPPGDLGLPFIGQNKKIFKNPQNFIEEVYQKYGPVYKTNFLGKNFIYFQGYEAIK
FILTNENKYFTYSQILRNYQRIFGENDITVLAGKEHRERQKILAKTIKSKNLNNYIDIIHDLSQSYFLKW
IKSDYVDLYSEINNYTLDMILKLLLGIDYASKSEISNYLKDMSSGLNTIPVVFPWTKFGSALESKNKLFN
QFEQIIVRRKKENNFGSDILGILLTVQEQMNYELTPREIVGQMVNLLSLGKKELSSALSSFFILTSEHLD
VLKLLQIEQEKMDVSEPLSLDKYKKMVYLEQVIKEVLRLVPPVSGGLRKIIEDCSFQGFRIPKGWHAYYY
ISSVLKDPEIYKQPEIFNPERFNPTNAEDKKKPLCYIPFGGGARECIGKEFAYLVIKIFISALLDNCSWK
FKENQDLTINTFPVARPAHKIEVCFTPK

CYP121A1 Mycobacterium tuberculosis

MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWL
VSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAI
TPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL
FRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHV
SDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRI
NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTS
HLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERL
PVLW

CYP121A1 Mycobacterium bovis subsp. bovis AF2122/97,

MTATVLLEVPFSARGDRIPDAVAELRTREPIRKVRTITGAEAWL
VSSYALCTQVLEDRRFSMKETAAAGAPRLNALTVPPEVVNNMGNIADAGLRKAVMKAI
TPKAPGLEQFLRDTANSLLDNLITEGAPADLRNDFADPLATALHCKVLGIPQEDGPKL
FRSLSIAFMSSADPIPAAKINWDRDIEYMAGILENPNITTGLMGELSRLRKDPAYSHV
SDELFATIGVTFFGAGVISTGSFLTTALISLIQRPQLRNLLHEKPELIPAGVEELLRI
NLSFADGLPRLATADIQVGDVLVRKGELVLVLLEGANFDPEHFPNPGSIELDRPNPTS
HLAFGRGQHFCPGSALGRRHAQIGIEALLKKMPGVDLAVPIDQLVWRTRFQRRIPERL
PVLW

CYP122A1 Streptomyces sp.

MSTDTPAGTPQAGRCPFAIQDAHRAILDSATVGSFDLFGIKHWL
VAAAEDVKLVTNDPRFSSAAPSEMLPDRRPGWFSGMDVPEHSRYRQKIAGDFTLRAAR
RQEEFVFEAADACLDEIEAAGPGADLVPGYAKRLPSLVINALYGLTPEEGAVLETRMR
GITGSTDLDSVKTLTDDFFAHALELVRAKRDERGDDLLHRLASAEDGEIPLSDDEATG
VFATLLFAGHDSVQQMVGYCLYALLSHPEQEGALRTRPELIDGAVEEMLRFLPVNQMG
VPRVCVADVDLRGVRISVGDNVIPLYSTANRDPEVFPDPDTFDVSRPTEGNFAFGHGV
HKCPGQHVARLLIKVACLRLLERFPDVRLVGDVPMNEGLGLFSPAELRITWGAA

CYP122A2 Streptomyces hygroscopicus

MSTEAQQESTPTARCPFSIQDGHRTILETGTVGAHELFGVKQWL
VAAAEDVKLVTNDPRFSSAAPSGILGDRRPGWFSGMDSPEHNRYRQKIARDFTLRAAR
KQEEFIVRAADSCLDDIEASGPGTDLVPGYAKRLASLAIHDLYGLNEEGPVLEGQMRA
MEGGTDMESIKRLTDEFGHVLALVRAKRDEAGDRLLHRLAESGEDEILLSDEEATGVF
ATLLFAGHDSMQQMVGYSLYALLSHPEQRAALRENPDLIDGAVEELLRFLPLNQLGVP
RVCVEDVELHGQTISAGDNVIPLYSTANRDPGVFADPDTFDITRKPEHNFAFGYGIHG
CPGQHLARVLIKVATVRLFERFPDVRLAGDVPMNEGLGLFSPAELRVTWGAE

CYP122A3 Streptomyces hygroscopicus var.

MSTDTHEGTPPAGRCPFAIQDGHRAILESGTVGSFDLFGVKHWL
VAAAEDVKLVTNDPRFSSAAPSEMLPDRRPGWFSGMDSPEHNRYRQKIAGDFTLRAAR
KREDFVAEAADACLDDIEAAGPGTDLIPGYAKRLPSLVINALYGLTPEEGAVLEARMR
DITGSADLDSVKTLTDDFFGHALRLVRAKRDERGEDLLHRLASADDGEISLSDDEATG
VFATLLFAGHDSVQQMVGYCLYALLSHPEQQAALRARPELVDNAVEEMLRFLPVNQMG
VPRVCVEDVDVRGVRIRAGDNVIPLYSTANRDPEVFPQPDTFDVTRPLEGNFAFGHGI
HKCPGQHIARVLIKVACLRLFERFPDVRLAGDVPMNEGLGLFSPAELRVTWGAA”

CYP123A1 Mycobacterium tuberculosis

MTVRVGDPELVLDPYDYDFHEDPYPYYRRLRDEAPLYRNEERNF
WAVSRHHDVLQGFRDSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVS
KGFTPRRIRELEPQVLELARIHLDSALQTESFDFVAEFAGKLPMDVISELIGVPDTDR
ARIRALADAVLHREDGVADVPPPAMAASIELMRYYADLIAEFRRRPANNLTSALLAAE
LDGDRLSDQEIMAFLFLMVIAGNETTTKLLANAVYWAAHHPGQLARVFADHSRIPMWV
EETLRYDTSSQILARTVAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGR
EIGCKLVSFGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGF
AHLPISVQAR

CYP123A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(861053..862261)
Gene = CYP123 100% match
locus_tag = Mb0789c

CYP123A2 Mycobacterium smegmatis

MSLPTVEPVLDPYDYDFHEDPYPYYKRLRDEAPLYRNDERNFWALSRHED
VLKGFRNSTALSNKHGVSLDPVSRNDEAHRVMSFLALDDPAHLRLRTLVS
KGFTPRRIRELEARVTEIAVQHLEIALQSDSFDFVDDFAGKLPMDVISEL
MGVPEEDRVRIRALADGVMHREDGVADVPASAIAASGELLVYYADMVKRR
RRNVSDDLTSALVEAEIDGDKLTDDEIMAFLFLMVVAGNETTTKLLANAA
YWGFKNPDQLAPVFDDHSQIPLWVEETLRYDTSSQILARAVVEDLTFYGT
TVPAGDVLVLLAGSANRDERAFDDPDEYRIGRDIGSKLVSFGSGAHFCLG
AHLARMEARVALAELFKRIRGYDVDESASVRVHSSSVRGFAHLPITVEKR

CYP123A3 Mycobacterium marinum MM4930

MSVHVGGPEL VLDPYDYDFH EDPYPYYRRL RDEAPLYHNQ ELGFWALSRH RDVHQGFRNS
TTLSNRDGVS LDPVSRGPHA TKTMSFLAMD DPAHLRLRTL VSKGFTPRRI RELEPRVTEL
AVAHLDTMLD MAGGSQTVDY VAEFAGKLPM DVISELMGVP VADRDQIRAM ADGVMHREDG
VTDVPASAIE ASINLIVYYQ QMIAERRKKP SDDLTSALLA ADVDGDRLTD EEVLGFMFLM
VIAGNETTTK LLANAAFWGH KNTDQLTPIY ADLSRVPLWV EETLRYDTSS QILARTVVGE
LTLYDTTIPE GDVVLLLPGS AHRDERAFRD PDEYLIGREI GSKLLSFGSG AHFCLGAHLA
RMEARVALTE LFKRIRGYQV DEGNAVRVHS SNVRGFAHLP ITVEVA*

CYP123A3 Mycobacterium ulcerans

MSVHVGGPELVLDPYDYDFHEDPYPYYRRLRNEAPLYHNQELGFWALSRRRDVHQGFRNS
TTLSNRDGVSLDPVSRGPHATKTMSFLAIDDPAHLRLRTLVSKGFTPRRIRELEPRVTEL
AVAHLDTMLDMAGGSQTVDYVAEFAGKLPMDVISELMGVPVADRDQIRAMADGVMHREDG
VTDVPASAIEASINLIVYYQQMIAERRKKPSDDLTSALLAADVDGDRLTDEEVLGFMFLM
VIAGNETTTKLLANAAFWGHKNTDQLTPIYADLSRVPLWVEETLRYDTSSQILARTVVGE
LTLYDTTIPEGDVVLLLPGSAHRDERAFRDPDEYLIGREIGSKLLSFGSGAHFCLGAHLA
RMEARVALTELFKRIRGYQVDEGNAVRVHSSNVRGFAHLPITVEVA

CYP123A4 Mycobacterium vanbaalenii PYR-1

MTISEVRLDPYNYDFHEDPYPYYKRLRDEAPLYRNEELGFWALSRHADVLKGFRNSTTLSNKFGVSLDPA SRGPHASKTMSFLAMDDPAHLRLRTLVSKGFTPRRIRELEPRVTEIAVTHLDAMLEQATTGDAVDYVDEF
AGKLPMDVISELMGVPDADRVQVRAWADAVMHRDDGVTDVPDSAIEASLNLIVYYQEMVAERRKKLTDDL TSALLEAEIDGDRLTDDEIIGFMFLMVIAGNETTTKLLANAAFWGHRNPDQLTSVYQDLARVPLWVEETL
RFDTSSQILARTVSGELTLYDTTIPDGDVVLLLPGSAHRDERVFENPDDYVIGREIGSKLMSFGSGAHFC LGAHLARMEARVALAELFKRIRGYEVDEANAVRVHSSNVRGFAHLPIRVEIR

CYP123A5 Rhodococcus sp. RHA1 Rha05833 and Rha05832

MTAASMPGVSHNPVTFNPYDYGFHEDPYVTYRRLREEAPLYYNEELDFWALSRHEDVVAAFRDNQRLSSANGVSLDPAAYGPHAHKTMSFLALDDPRHMRMRQLVSRGFTPRRVNELEGRILDLTRQYLDPALAAGEFDWIGEFAGKLPMDVISELMGVPEADRVELRRLADLVV
HREEGVLDVPHAAMEASLYLVGYYADMLAERRRKPTEDLTSALLEAEIDGDRLTDDEIIAFMS
MRCTGVSAIRARLGNVFEDASRVPEWVEXTLRFDTSSQMVARTASVDLDFHDRTIPAGDKVLILIGSANRDSAVFEDADEYRIGRDTSNKLASFGGGTHFCLGAHMARLEARIALTELVSRIDDYDIDEANSVRVHSTNVRGFATLPMKVQVRDA

CYP123B1 Mycobacterium marinum MM4833

MWQETLMSTV QLRYDPFDPE IQDDPYPVYR QLRDDAPVYH ATDTNTWVLS RHADVISALL
DHHSYSSVDG VFPTPPGSTF RESLLPMMIL MDPPRHDQLR ALVSKAFTPR RIAALTSAIE
DLADHLTGGL IQEAGSADFV ADFAAVLPAM VIADLLGVPR EDRTQFRQWS NALVQSNPTH
GETGEALAAA AAIYGYFTDF LADRRRQPRD DLMSALVCAE IDGKHLSDDE LLGFCLLLLI
AGHETTSNLL ANAAVVLADY RDTRRQLAGD ESLLGAAVEE LLRYDSPAQG LSRTLTRDVT
VHGVRMSAGE SVLLLFGSAN RDERVFADPD VFDIGRKPEH QVAFGRGIHF CLGASLARME
ARIALRALLA RVPNWEVDLE RAQRLRSGPI RGYLSLPISW SAN*

CYP123B2 Mycobacterium vanbaalenii PYR-1

MVSVQIRYDPFDASILNDPYPTYRLLRDVAPVYRAEESHTWVLSRHADVQAAALDHSTYSSVDGIFPTPP
GSDFIGSFLPMMIVMDPPRHDQLRALVSRAFTPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAI
LPAAVIADLLGVPATDRDQFRLWSSQLVQVDVNHGQTTDALAAAAAIYAYFTDFLADRRKNPREDLMSAL
ANATVDGIGLTDEEVLGFCALLLVAGYETTTNLLGNSAVVLAQHRQTRRRLAADRTLLGPAVEELLRYDS
PAQGLSRTLTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTSEHQVAFGRGIHFCLGAAL
ARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGYTSLPITWTTPV

CYP124A1 Mycobacterium tuberculosis

MGLNTAIATRVNGTPPPEVPIADIELGSLDFWALDDDVRDGAFA
TLRREAPISFWPTIELPGFVAGNGHWALTKYDDVFYASRHPDIFSSYPNITINDQTPE
LAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEAAVRDRAHRLVSSMIANNPDRQ
ADLVSELAGPLPLQIICDMMGIPKADHQRIFHWTNVILGFGDPDLATDFDEFMQVSAD
IGAYATALAEDRRVNHHDDLTSSLVEAEVDGERLSSREIASFFILLVVAGNETTRNAI
THGVLALSRYPEQRDRWWSDFDGLAPTAVEEIVRWASPVVYMRRTLTQDIELRGTKMA
AGDKVSLWYCSANRDESKFADPWTFDLARNPNPHLGFGGGGAHFCLGANLARREIRVA
FDELRRQMPDVVATEEPARLLSQFIHGIKTLPVTWS

CYP124A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome 2519058..2520344
Gene = CYP124 100% match
locus_tag = Mb2289

CYP124A1 Mycobacterium avium subsp. paratuberculosis str k10

MSLKTRPKKGLATRINGAPPPRVPLADIHLESLDFWGYDDDFRD
GAFATLRREAPISFWPAIEMDGFVAGNGYWALTKHEDVHFASRHPEIFSSVPNITIND
QTPELAEYFGSMIVLDDPRHQRLRSIVSRAFTPKVVARIEASVRERARRLVSSLVANH
PNGEAELVSELAGPLPLQVICDMMGIPEEDHQRVFHWTNVILGFGDPDLATDFEEFLQ
VSMDIGAYATALAEDRRVNHHDDLTTSLVEAEVDGERLTSSEIASFFILLVVAGNETT
RNAISHGVLALSRYPDERDKWFSDFDRLTPTAVEEVVRWASPVVYMRRTLTRDVKLRG
TKMKAGDKVALWYNSANRDESTFGNPWLFDVARTPNPHLGFGGGGAHFCLGANLARRE
IRVVFDELRHEIPDIVATEEPARLLSQFIHGIKRLPVAWTPPR

CYP124A1 Mycobacterium marinum MM3361

MDLSTNLNTG LLPRVNGTPP PEVPLADIEL GSLEFWGRDD DFRDGAFATL RREAPISFWP
PIELAGLTAG KGHWALTKHD DIHFASRHPE IFHSSPNIVI HDQTPELAEY FGSMIVLDDP
RHQRLRSIVS RAFTPKVVAR IEASVRERAH RLVAAMIENH PDGQADLVSE LAGPLPLQII
CDMMGIPEED HEQIFHWTNV ILGFGDPDLT TDFDEFLQVS MAIGGYATAL ADDRRVNHHG
DLTTSLVEAE VDGERLSSSE IAMFFILLVV AGNETTRNAI SHGMLALSRY PDERAKWWSD
FDGLAATAVE EIVRWASPVV YMRRTLSQDV DLRGTKMAAG DKVTLWYCSA NRDEEKFADP
WTFDVTRNPN PQVGFGGGGA HFCLGANLAR REIRVVFDEL RRQMPDVVAT EEPARLLSQF
IHGIKRLPVA WSR*

CYP124A1 Mycobacterium ulcerans

MDLSTNLNTGLLPRVNGTPPPEVPLADIELGSLEFWGRDDDFRDGAFATLRREAPISFWP
PIELAGLTAGKGHWALTKHDDIHFASRHPEIFHSSPNIVIHDQTPELAEYFGSMIVLDDP
RHQRLRSIVSRAFTPKVVARIEASVRERAHRLVAAMIENHPDGQADLVSELAGPLPLQII
CDMMGIPEEDHEQIFHWTNVILGFGDPDLTTDFDDFLQVSMAIGGYATALADDRRVNHHG
DLTTSLVEAEVDGERLSSSEIAMFFILLVVAGNETTRNTISHGMLALSRYPDERAKWWSD
FDGLAATAVEEIVRWASPVVYMRRTLNQDVDLRGTKMAAGDKVTLWYCSANRDEEKFADP
WTFDVTRNPNPQVGFGGGGAHFCLGANLARREIRVVFDELRRQMPDVVATEEPARLLSQF
IHGIKRLPVAWSR

CYP124A1 Mycobacterium smegmatis

MGIAPRVNGAAPPDVPLSEINLGSWDFWALDDDIRDGAFATLRREAPISF
HPAFDTEEGFPQGAGHWALTRHDDVFYASRHPELFSSASGIVIGDQTPEL
AEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAVIEDSVRDRARRLVAGMV
DRNPDGHAELVTELAGPLPLQIICDMMGIPESDHQQIFHWTNVILGFGDP
DLTTDFDEFVTVAMDIGAYATALADQRRSAPADDLTTSLVQAEVDGERLT
SAEVASFFILLVVAGNETTRNAISHGVLALTRYPEQRRLWWSRFDELAPT
AVEEIVRWASPVSYMRRTVTRDTELAGTALPAGSKVTLWYGSANRDETKF
DNPWMFDVQRHPNPHVGFGGGGAHFCLGANLARREITVLFSELHRHLPDI
VATEEPDRLQSAFIHGIKRLPVAWR

CYP124A1 Mycobacterium vanbaalenii PYR-1

MSLGMGIEKSAVTRTNGVAPPEVPLADIDLGSWDFWGLDDDYRDGAFATLRREAPISFHEAYVIDPDNEV
AGHWALTRHDDVFYASRHPEIFSSALGITVGDQTPELAEYFGSMIAMDDPRHTRLRNIVRSAFTPRVLAL
IEDSVRQRARSLVQQMVAAHPDGNGELVAELAGPLPLQIICDMMGIPEEDHQKIFHWTNVILGFGDPDIA
TDFDEFVSVAMGIGAYATQLADDRRDHPGDDLTTSLVAAELDGERLTSAEVASFFILLVVAGNETTRNAI
SHGVLALSRYPEQRQRWWSDYQGMAPTAVEEIVRWASPVAYMRRTATRDVEMSGVRIAAGDKVSLWYGSA
NRDESKFENPWLFDVGRHPNPHVGFGGGGAHFCLGANLARREITVAFEELHRLVPGIRAVEEPDRLHSAF
IHGIKRLPVSWSA

CYP124B1 Streptomyces cinnamonensis

MGLTVGPDNAKRGIVPITDSKPAATFPDLVDPSFWARPHAERVA
LFEEMRGLPRPAFIRQNMPGVPWTFGYHALVKYADIVEVSRRPQDFSSNGATTIIGLP
PELDEYYGSMINMDNPEHSRLRRIVSRSFGRNMIPEFEAVATRTARRIIDELIARGPG
DFIRPVAAEMPIAVLSDMMGIPAEDHDFLFDRSNTIVGPLDPDYVPDRADSERAVIEA
SRELGDYIAGLRAERLAAPGNDLITKLVQVQADGEQLTRQELVSFFILLVIAGMETTR
NAISHALVLLTEHPEQKQLLLSDFDTHAPNAVEEILRVSTPINWMRRVATRDCDMNGH
RFRRGDRIFLFYWSGNRDESVFPDPYRFDITRGTNAHVTFGAVGPHVCLGAHLARMEI
TVLYRELLAALPQIHAVGQPRRLDSSFIEGIKHLHCAF

CYP124B2 Streptomyces nanchangensis NS3226

MNRGVVSPTEATPASSAKATRPPDFMDPSFWLRPRDERAEVFEK
LRALPGPEFVPPRLPWGPLASGYYALSKHADICEVSRRPQDFSSEGATAILPPEMDEF
YGSMINMDNPEHSRLRRIVARSFGRGMAPKFDAMSRRVARRIVDELIERGPGDFIRPA
AEMPIAVLSTMMGIPGEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDY
IGRLREDRLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQAL
VLLTEHPDQRQLLLSDFELHAKGAVEEILRVGTPINWMRRTATGDCEMNGHRFRKGDE
IFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFCLGAHLARIEIIAMLREL
LASLPDIRVEGEPVRLASSFIEGFKELSCTF

CYP124B2 ortholog SBI_3705 Streptomyces bingchengensis

99% to CYP124B2 Streptomyces nanchangensis NS3226
only 3 aa diffs
MDPSFWLRPRDERAEVFEKLRALPGPEFVPPRLPWGPLASGYYALSKHAD
ICEVSRRPQDFSSEGATAILPPEMDEFYGSMINMDNPEHSRLRRIVARSF
GRGMVPKFDAMSRRVARRIVDELIERGPGDFIRPAAEMPIAVLSTMMGIS
GEDYEFLFERTNTIMGGADPELAADPEKMAAAVLGALRDLGDYIGRLRED
RLARPGPDVITKLVQVQEDGEQLTNQELVSFFILLINAGMETTRNVIAQA
LVLLTEHPDQRQLLLSDFELHARGAVEEILRVGTPINWMRRTATGDCEMN
GHRFRKGDEIFLFYWSANHDEKVFEDAYRFDITRDPNPHLSFGAVGPHFC
LGAHLARIEIIAMLRELLASLPDIRVEGEPVRLASSFIEGFKELSCTF

CYP124C1 Rhodococcus sp. RHA1 Rha04649

VTGSASEKIISPASRAFWDRSFAGRRAMFEELRQRSPIEFHAETAGPGFWSVVGYDDVVAVSRNPEVFSSAKGFTIDDVPAEILEFAMSMIAMDDPRHRRLRGIVQSAFTAASVRGIAERVRGTAAQIAADLPRDAEFDFVPDVATRLPVQVICELIGIPENDRPMILAAAADVVAGGGD
QEFVTAPGGAAGLGQIYGYALELGERRKADPGEDLTSRLVSTMVDGEALAPTEFGSFVILLITAGFETTRQALAWALLLLSEHPDQKELLLADFAGHIDNTIDEVIRFASPVPYMRRTATVDTELGGAHIAAGDKVVMWYLSANHDERVFDGPGRFDITRANAGKHLGFGAKDIHHCL
GVNLARLELRVMLEELFTAHPTLHAVGEPELLLSAFISGVAALPARTRDGR

CYP124F1 Frankia alni ACN14a

MSLIADVDLDDLDWWTRPAAERDAYFASVRASGERPYFPELDLAGNTRGRGFYAVTRYADVMEVSRRPED
FCSGEGTNIFDQPLDLREFFGSIIAMDNPQHARQRRIISRGFTAKNLEALRANVGEVTREVLATVAEKGE
CDFVTEVAALIPLRIVNDMMGIPRSQEQFIFESTNKLLGASDPEYVPDQSPRGVAKNLSRVGDDFAELLR
ELAADRQRNPGDDLISLLVAAEGENLTAQELASFFILLVGAGNETTRNAIAHGLLALTQNPDQRALWASD
VDGLTPTAVDEVVRWASPVLHMRRTVTADGVRLGDQEFREGDKLVLWYRSANQDESVFPDGTRFDVRRDL
TPPHLGFGAPGPHFCLGAHLARLELSVVFKALFEYLPDIHAVEEPQFLRTNFLHGIKHLKAAYTPTTVRA

CYP124F2 Frankia alni ACN14a

MPGTRGLPGDVLDDLSWWTRPAAERDATFAWLRAHDPRPYVPELDLTGAPRGGGFWALTRLDDVREVSRR
PADFCSGQGSLIFDQPPRLREFRGSIIDMDNPEHARQRRIVARGFTPKAVAALVEDIARTSREVISAVAR
RGECDFVTEVAALLPLRIVNNLLGIPRSEERFLFEQTNILMGASDPEYVPDQTPRSVARAVHGAGQAMSG
LLEELARDRIRNPQDDLVSSLVAAQEEENLTPTELATFFNLLVGAGNETTRNALAHGLSALTRFPDQREL
WRSDLDRYTPGAVEELLRWASPVLYMRRTVARDGVTLGEQRFDAGDKVVLWYRSANQDEAYFDDATAFRV
TRDPNPHVTFGAPGPHHCLGANLARVELAIAFRTLFELLPDIEATAEPDLLRSNFLHGVKHLPARFTPTA
PRP

CYP124G1 SGR529 Streptomyces griseus

42% to CYP124B1 Streptomyces cinnamonensis
42% to CYP268A2 Mycobacterium marinum MM3761
top 19 hits are CYP124 or CYP268. These families overlap
MLLAAGGRTMAWRTVEVMDMTVPYQLSEGRVLRAADVDLADPAFWRLPRPVRLRAFALLRELEEPVLFTPRAGTARTAGKPFRALVRHADVRTASRTPQVFASAPGVTTPEPAGWAKALFGNSMVNMDGPEHAALRRIISRRFTPRLLAEAEENVGRLAGRLVDELIAERPRDFM
PSAASRLPLEVICDLMGVPAAYRARIAEQIDHASEHVGVERRGRARLRIPGRGLASLARMQFVMGRLARERRQRPEDDLVSALVNADIDGEALSGRQLGAFFSLLLVAGVETTRNAIAHGLFLLDRHPEQRELLRSDFDRYIDGAVDEIVRHSTPIIQFRRTVAEECALGGRTFLPGEKV
ALIYASANRDETVFTHPDRFDITRSPNPHLGYGGGGPHHCLGAHLARLEMTALFRELIARRPVMRDLGDPDLVDSNFDNRVGSLPFTFGPTFT

CYP125A1 Mycobacterium tuberculosis

MSWNHQSVEIAVRRTTVPSPNLPPGFDFTDPAIYAERLPVAEFA
ELRSAAPIWWNGQDPGKGGGFHDGGFWAITKLNDVKEISRHSDVFSSYENGVIPRFKN
DIAREDIEVQRFVMLNMDAPHHTRLRKIISRGFTPRAVGRLHDELQERAQKIAAEAAA
AGSGDFVEQVSCELPLQAIAGLLGVPQEDRGKLFHWSNEMTGNEDPEYAHIDPKASSA
ELIGYAMKMAEEKAKNPADDIVTQLIQADIDGEKLSDDEFGFFVVMLAVAGNETTRNS
ITQGMMAFAEHPDQWELYKKVRPETAADEIVRWATPVTAFQRTALRDYELSGVQIKKG
QRVVMFYRSANFDEEVFQDPFTFNILRNPNPHVGFGGTGAHYCIGANLARMTINLIFN
AVADHMPDLKPISAPERLRSGWLNGIKHWQVDYTGRCPVAH

CYP125A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(3927359..3928660)
Gene = CYP125A1 100% match
locus_tag =Mb3575c

CYP125A2 Streptomyces avermitilis

MPCPALPDGFDLTDPDLLHQRVPLPEFAELRRTAPVHWVPQQHG
LAGFQDDGYWAVTRHADVKYVSTHPELFSSYLNTAIIRFHETMQREQIDAQRLFMLNM
DPPEHTRVRQIVQRGFTPRAIRALEDTLRRRARSIVETALADAGPDGSFDFVTQVACE
LPLQAIAELIGIPQDDRAKIFDWSNKMIAYDDPEYAITEEVGAESATELIAYAMNMAA
DRKQCPAKDIVSTLVAAEDVGNLASDEFGFFVLMLAVAGNETTRNAITHGMHAFLTHP
DQWDLYKRERPATAAEEIVRWATPVVSFQRTATQDTELGGKQIRKGDRVGIFYSSANH
DPEVFEHPDVFDITRDPNPHLGFGGGGPHFCLGKSLAVVEIDLIFGAIADVMPGLRLT
GDPRRLRSAWLNGVKGLQVSAG

CYP125A3 Mycobacterium smegmatis

MPTPNIPSDFDFLDATLNLERLPVEELAELRKSEPIHWVDVPGGTGGFGD
KGYWLVTKHADVKEVSRRSDVFGSSPDGAIPVWPQDMTREAVDLQRAVLL
NMDAPQHTRLRKIISRGFTPRAIGRLEDELRSRAQKIAQTAAAQGAGDFV
EQVSCELPLQAIAELLGVPQDDRDKLFRWSNEMTAGEDPEYADVDPAMSS
FELISYAMKMAEERAVNPTEDIVTKLIEADIDGEKLSDDEFGFFVVMLAV
AGNETTRNSITHGMIAFAQNPDQWELYKKERPETAADEIVRWATPVSAFQ
RTALEDVELGGVQIKKGQRVVMSYRSANFDEEVFEDPHTFNILRSPNPHV
GFGGTGAHYCIGANLARMTINLIFNAIADNMPDLKPIGAPERLKSGWLNG
IKHWQVDYTGAGKASVSGAPGTCPVAH

CYP125A4 Mycobacterium smegmatis

MSDSALHLPAGFDFTDPDIYAERLPVDELAELRRVAPIWWNAQPIGAGGF
DDGGFWVVTKHKDVKEISLRSDVFSSLEKTALPRYPEGTVQDQIEQGRFV
LLNMDAPHHTHLRKIISRAFTPRAVERLRDDLAERARAIVRAAAEEGSGD
FVEQVACELPLQAIAGLMGVPQEDRRKLFDWSNQMVGNQDPEFVANDGAS
AAVELITYGMQLAAQRAAAPGDDLVTKLVQADVEGHKLSDDEFGFFVVLL
AVAGNETTRNSITQGMMAFTDHRDQWELFKRERPVTTADEIVRWATPVTS
FQRTALADTEVSGVRIKKGQRVVMFYRSANFDEDVFTDPYRFDILRDPNP
HVGFGGTGAHYCIGANLARMTIDLIFNAIADEMPDLTPISEPVRLRSGWL
NGIKHWQVDYRGDAAKHRAAQASSQADR

CYP125A5P Mycobacterium smegmatis

MATMNTCPFGNGYDFTDPDVLFRGIPVEEFAVLRKTAPVWWNQQGESIFDDGG
YWVISRHEDIKTISRDGGEVWSTNAKGAVMRLPDGVTAEQLDLTKALLIN
HDAPEHTRLRKLVSRLFTPRSVAALEEKLAVAAHDIVAEAKAEGSGNFVE
DIAMKLPLLAIADLIGVPEADREKIFAWSNAIINTDDPDFDSDPTVANAE
LMGYAYTMAEERRRCPADDIVTRLVQADVSGESLGEVEFAFFVILLAVAG
NETTRNAITHGMNAFFENPDQWELFKRERPITAVDEIVRWATPVHCFQRT
AVVDTEIGGVPIKAGQRAGLFYSSANYDEDVFDDPFRFDILRDPNPHLGF
GGNGAHYCIGANLARMEIRLMFDEIADQIPDITKVGEPQRLRSGWINGVK
DLQVSYRG*PARLIYYSRMRTHGWSGSAPATD

CYP125A6 Mycobacterium marinum MM2783

MPAAEPTATS VPNLPPGFDF TDPDIYAERL PVAELAEMRR SAPIWWNEQP TGCGGFDDGG
FWVVTKHKDV KEISLRSDVF SSLQKTALPR YKDGTVDEQI ERGKFVLLNM DAPQHTRLRK
IVSRAFTPRA VERLRDDLRE RARRIVEAAA AEGRGDFVEQ VSCELPLQAI AGLMGVPQED
RKKLFHWSNE MVGDQDPEFA TNDALTASVE LIMYGMQMAA DRAKNPGQDL VTKLVEADID
GHKLSDDEFG FFVILLAVAG NETTRNSITQ GMMAFTDFPD QWELYKRERP VTTADEIVRW
ATPVTSFQRT ALQDYELSGV RIKKGQRVVM FYRSANFDED VFDDPYTFNI LRDPNPHVGF
GGTGAHYCIG ANLARMTIDL MFNAIADVMP DLESISQPER LRSGWLNGIK HWQVDYHSDS
SGKCPVAH*

CYP125A6P Mycobacterium ulcerans

MPAAEPTATSVPNLPPGFDFTDPDIYAERLPVAELAEMRRSAPIWWNEQPTGCGGFDDGG
FWVVTKHKDVKEISLRSDVFSSLQKTALPRYKDGTVDEQIERGKFVLLNMDAPQHTRLRK
IVSRAFTPRAVERLRDDLRQRARRIVEAAAAEGRGDFVEQVSCELPLQAIAGLMGVPQED
RKKLFHWSNEMVGDPGLRRC
LLEANSGQDPRFAAADHDDRELRRALRRQGVGDQDPEFATNDALTASAELIMYGMQMAAD
RAKNPGQDLVTKLVEADIDGHKLSDDEFGFFVILLAVAGNETTRNSITQGMMAFIDFPDQ
WELYKRERPVTTADEIVRWATPMTSFQRTALEDYELSGVRIKKGQRVVMFYRSANFDEDV
FDDPYTFNILRDPNPHVGFGGTGAHYCIGANLARMTIDLMFHAIADVMPDLESISRPERL
RSGWLNGIKHWQVDYHSDSSGKCPVAH

CYP125A7 Mycobacterium marinum MM5032

MPCPNLPPGF DFTDPDIYAE RLPVEEFAEL RSSEPIWWDE QLPGQGGGFH DGGFWAITKL
KDVKEVSRRS DVFSSYENGV IPRFKNDIAR EDIDVQRFVM LNMDAPHHTR LRKIISRGFT
PRAIGRLHDE LNDRAQNIAK AAAAAGSGDF VEQVSCELPL QAIAGLLGIP QEDRGKLFDW
SNEMTGTEDP EFAHIDAKAS SVELIGYAMK MAEEKAKNPG DDIVTQLIQA DIDGEKLSDD
EFGFFVVMLA VAGNETTRNS ITQGMMAFAD NPEQWELYKR ERPETAADEI VRWATPVTSF
QRTALEDYEL SGVQIKKGQR VLMFYRSANF DEEVFEDPFS FNILRNPNPH VGFGGTGAHY
CIGANLARMT INLIFNAVAD HMPDLTPIAA PERLRSGWLN GIKHWQVDYT GKCPVSH*

CYP125A7 Mycobacterium ulcerans

VPCPNLPPGFDFTDPDIYAERLPVEEFAELRSSEPIWWDEQFPGQGGGFHDGGFWAITKL
KDVKEVSRRSDVFSSYENGVIPRFKNDIAREDIDVQRFVMLNMDAPHHTRLRKIISRGFT
PRAIGRLHDELNDRAQNIAKAAAAAGSGDFVEQVSCELPLQAIAGLLGIPQEDRGKLFDW
SNEMTGTEDPEFAHIDAKASSVELIGYAMKMAEEKAKNPGDDIVTQLIQADIDGEKLSDD
EFGFFVVMLAVAGNETTRNSITQGMMAFADNPEQWELYKRERPGTAADEIVRWATPVTSF
QRTALEDYELSGVQIKKGQRVLMFYRSANFDEEVFEDPFSFNILRNPNPHVGFGGTGAHY
CIGANLARMTINLIFNAVADHMPDLKPIAAPERLRSGWLNGIKHWQVDYTGKCPVSH

CYP125A8 Streptomyces scabies SCAB65311

MLRQESPMPC PALPDGFDLT DPDLLHHRVP LPEFAELRRA EPVHWIPQAP GIAGFADEGY
WAVTRHADVK YVSTHPELFS STVNTAIIRF NEHIERDAID AQRLILLNMD PPEHTRVRQI
VQRVFTPRAI RALEDNLRHR ALNIAREAGA HAGPFDFVTE VACELPLQAI AELIGIPQED
RIRIFEWSNR MISYDDPEYA ITEEVGQQSA MELIAYAMNM AADRKQCPAK DIVTTLVAAE
DEGNLTSDEF GFFVLMLAVA GNETTRNAIT HGMHAFLTHP DQWDLYKRER PATAAEEIVR
WAAPVNAFQR TATQDLELGG KRISKGDRVG IFYASANHDP DVFTDPDTFD ITRDPNPHLG
FGGGGPHFCL GKSLAVLEID LIFNAIADAM PGLRLAGEPS RLRSAWINGV KHLQVTTA

CYP125A9 Mycobacterium vanbaalenii PYR-1

MPGPNSCPISPEFDFLDASLNLERLPVEELAELRKSEPVHWVDVPGGTGGFGDRGYWLVTKHADVKEVSK
HNEIFGSSPDGAIPVWPQEMTREAIDLQKAVLLNMDAPQHTRLRKIISRGFTPRAVGRLEDELRARAQRI
AATAATEGSGDFVEQVSCELPLQAIAELLGVPQEDRDKLFRWSNEMTAGEDPEYADVDPAMSSFELITYA
MKMAEERAKNPTEDIVTKLIEADIEGEKLSDDEFGFFVVMLAVAGNETTRNSITHGMIAFSRNPDQWELY
KKERPETAADEIVRWATPVSAFQRTALEDTELGGVQIKKGQRVVMSYRSANFDEEVFENPHSFDIMRNPN
PHVGFGGTGAHYCIGANLAKMTINLMFNAIADAMPDLKPIGDPERLKSGWLNGIKHWQVDYTGQCPVQH

CYP125A10 Mycobacterium vanbaalenii PYR-1

MATPTLPPGFDFTDPDLNLERLPVEELAELRRCAPIWWNEQTSGGAGPFGDGGYWVVTKHRDVKEISKHS
EVFSSQQKTALPRYPEGSTTEQVETGSLVLLNMDAPRHTHLRKIISRGFTPRAVERLREDLAQRAHNIAK
SAAAAGAGDFVEQVSCELPLQAIAGLLGVPLEDRKKLFDWSNQMVSDDDPEFAHYDNRNAATELIMYAMQ
LAALRAEQPGEDIVTKLIEADVDGHKLTDDEFGFFMVLLAVAGNETTRNSITHGMIAFTEHPDQWELFKR
ERPATAVDEIVRWATPVTSFQRTALRDYELSGVQIKKGQRVVMSYRSANFDEEVFDDPFTFDIMRDPNPH
VGFGGTGAHYCIGANLARMTIDLMFNAIADHLPDLSSAGTPDRLRSGWLNGIKHWQVDYTGPSGCPVAH

CYP125A11 Mycobacterium vanbaalenii PYR-1

MTATQSCPFLPHGYDFTDPDVLLKGIPVTEFAELRRTAPVWWNEQADSIFDDGGYWVISRHEDVKAISRN
STQWSTNTKGAVMRLPDGVTAEQLDLTKALLINHDAPEHTRLRKIVSRLFTPRAIAGMEDRLADAAREIV
RSAAEKDSGDFVDDVAMMLPLQAIADLIGVPEEDREKLFHWTNAIMNTDDPEFDADPTMANAELMGYAYS
MAEERRRCPADDIVTRLVQADIDGESLGEVEFAFFVILLAVAGNETTRNAMTHGMNAFFDNPAQWELFKR
ERPETAIDEIIRWATPVHCFQRTALEDVEVGGVTIAEGQRVGLFYSSANFDEDVFDRPFDFDILRDPNPH
LAFGGNGAHFCIGANLARMEIKLMFNEIADQIPDISKLAEPQRLRSGWINGVKNLQVAYR

CYP125A12P Mycobacterium leprae

1 PGFDFPDPEIYTEQLSV*EPAEMCQAETI**NEQPIGRSGFYDDDY 138
XXXXXXXXXXXXXX
174 HSGTFSNLEKTALACYQEGMNDEQISRGKLVLLNIDASQYTRLHKIISPGFIP*AAEQLR 353
354 DDLXXXXXXXXXXXXXXX 362
410 SGDFVEHVSCELSRQAAIAGLPSG 481
480 VPQEDCKKLFHWSN 521
522 QTVGAQDPKFATNDPMVTSVKLIM*AMQIAADRAKPLGQVIVTNLVEADIEGHKLSKDEFGSF 710
713 VIMLTAAGKENTRNCIMQSMMQFTNFPD*WELYK 814
816 KKAPGTTADKIIRQATLVMS 875
876 FQRTVLK*YELSSVSIKKGQRVVVIYRSANFDEKVLTIRLPCSIMRNPT 1022
1022 PHAGFNDTNVHYCIGIN 1072
1073 LARMTIDRMFHAIAESMPNL*STGKPK*LRSGWLNGVKHWQVD 1201

CYP125A13 Streptomyces peucetius

MSCPHLPQGFDFTDPDLLQARVPHPEFAEMRRTAPVWWCEQPAGISGFDDEGYWAVTRHA
DVRHVSTHPELFSSNTNTAVIRFNESISRDQIEVQKLIMLNMDPPEHTRVRQIVQRGFTP
RAVRSLEAALRRRARSIVETAAAGAKPDGSFDFVTNIAVELPLQAIAELVGVPQEDRSKI
FDWSNKMAAYDDPEYAITEEVGTEAAMEIVSYAMNLAAARKECPAQDIVSRLVAAEGERQ
PVLRRIRLLRHPAGGGRGTRPPR
NAISHGMH
GVPHPPRAVGELYSGCAPTRRPRENLRLGGTPGGFLSNGPGTQERGSLGGAAYX

CYP125A14P Rhodococcus sp. RHA1 Rha05823

VGSFPCPQKIEQVLLSGQGLNELSFASRPACASMLVERVPHHGVVYGLGQETAVAQPNLPEGFDFTDPDVYAERIPYQEFAELRKTAPIWWNPQPPEIGGFHDDGYWVVSKLEDVKEVSRRSDVFSTHENTAIVRFADDIPRENIEMQRFILINKDAPEHTKLRKLVSRGFTPRAINSLR
EELTERAEKIVKEAAESGAGDFVTQVACELPLQAIAELLGVPQEDRLKVFDWSNQMTGYDDPELDIDPQAASMEILGYAYQMADERKKCPADDIVTTLIEADIDGNELSPEEFGFFVILLAVAGNETTRNAITHGMMAFLDHPDQWELYKKERPKTTADEIVRWATPVNSFQRTALED
TELGGVQIKKGQRVVMLYGSANFDEDAFENPEKFDIMRENNPHVGFGGTGAHFCLGANLARLEIDLIFNAIADHLPDISKLGDPRRLRSGWLNGIKEFQVDYKTASGGCPVRH

CYP125A15 Salinispora tropica (marine actinomycete)

MTEPRIPVGFDFTDPAVLERRVPREEFAELRRTAPVWWNVQPRGSAGFDDDGYWVVTRYA
DVMAVSRDSDTYSTRENTAIARFQPGTTRADLEMQRVIMLNVDPPEHTKLRAIVSRGFTP
RAINALRGSLAERAERIVRDAAVRGTGDFVADVACELPLQAIAELIGVPQHHRRKVFDWS
NQLIGYDDPAYGVDPLTAAAELLAYAMEMANERQLNPSDDLVTKLVNAQIDGEHLTTDEF
GFFVMLLAVAGNETTRNAITHGMLAFLEHPEQWELFKAERPRSAVEEIIRWATPVNVFQR
TALVDTTLGGQAISAGQRVALFYGSANFDESVFEEPERFDITRSPNPHLGFGGSGAHFCL
GANLARLEIELIFHSIADHMPDIRKVAEPRRLRSGWINGIREMPVRYR

CYP125A16 SBI_1118 Streptomyces bingchengensis

79% to CYP125A2 Streptomyces avermitilis
MSCPALPEGFDFTDPDIYQQRLPFPEFAQLRQTDRVWWIPQPHGVAGFDD
DGYWAVTRHADVKEVSTKPEIFSSHLNTAIIRFNEHIHRDQIDVQKLIML
NMDPPEHTRVRQIVQRGFTPRAIRALEDALRERATRIVAGAKEDGSGDFV
TDVAFGMPLQAIAELIGVPQQDRSKIFDWSNKMVAYDDPELAITEEIGAE
SAMELISYAMNLAADRKACPAKDIVSQLVAAEDQGNLASDEFGFFVLLLA
VAGNETTRNAISHGMHAFLTHPDQWELFKRERPASAADEIVRWATPVMSF
QRTATQDTELGGQRIAAGQRVGIFYSSANHDPEVFDRPEDFDITRDPNPH
LGFGGGGPHFCLGKSLAELEIRLIFNAIADAMPDVRLAGDPRRLRSPWLN
GIKELQVNYG

CYP125A19 SGR5169 Streptomyces griseus

MRCPHLPDGFDFTDPDLLQSRVPHPEFALMRETAPVWWCTQPRNISGFGDEGYWAVTRHADVKYVSTHPELFSSNTNTAVIRFNETISRDQIDVQKLIMLNMDPPEHTRVRQIVQRGFTPRAVRSLEAALRSRARSIVGTAQASADAHGSFDFVTDIAVELPLQAIAELIGVPQEDRSKI
FDWSNKMAAYDDPEYAITEEVGAEAAMEIVAYSMNLAAARKECPAQDIVSQLVAAEGEGNLSSDEFGFFVILLAVAGNETTRNAISHGMHAFLTHPEQWELYKRERPKTTAEEIVRWATPVVSFQRTATQDVELGGQRIRKGERVGLFYSSANNDPEVFDAPEAFDITRDPNPHLGF
GGGGPHFCLGKSLAVMEIDLIFNAIADVLPDLRLLEDPRRLRSAWLNGIKELRVTTAAA

CYP125B1 Rhodococcus sp. RHA1 Rha05835

MTASRIDLKCPDVYTEGVPYAFFDHLRSSEPVYWQPEENGTGFWAVTRHADVVAVSRDSVTFSSAVGTTQIDDFDEQTRAKQAAMLVNLDPPDHTRLRQLVSRGFTPRTVKVLEGHIRDICTRIVDRLLEARDVDFVPEAAAPLPLEVIAALLGAPPGDVDRLYDWSNRMIGFDDPE
YGTTQADGELAAAEIFLYANELAAQRRIEPRDDIVTKLVQPDENGDTLTEMEFNMFFVLLVVAGNETTRNATAGGMQAFIDHPDQWRRLQSEPDLASSAVEEILRWVTPVMDFRRTATRDAYIGDQLVRAGDKVVIYYPSANRDEAVFDEPYRFDIGRSPNPQIAFGGSGVHFCLGA
HLARLELRILFETLAARIDRVESTGPVARLRSNFISGIKTMPVRIHPRSPV

CYP125C1 Rhodococcus sp. RHA1 Rha04272

MTLSALHTDLGSPDAYIHGVPHQVFAELRRHEPVAWIEEPAGEGFAGGPGFWAVTRYDDVMTVSKKPDVFSSHKGASFLRDQSPQDLAALQQMMLNLDPPDHSQMRSIVSKVFTPKMVRGMFDSIADHARAIVDALPDDGEIDLVEHVSAEMPLRVLADVLGVPSEDRHLLYDWT
NRMVGLDDPSYGGREAFLSAFIEMFEYSAAQTRAKRTEPGSDVWSLIVNAEVDGTQLSPEELNRFFQLLVIAGNETTRNLLTGAILTLGEHPGEREKLADDPALLPNAIEEVLRFHSPVIQFRRTVTRSTELGGKQMHEGQKVVIFYVSANRDEAQFDDPDTFRIDRGAANHLAFGAGT
HFCLGNSLARLEAKVLLEALFTRFPHWQVTGPPDRFRSNFIHGIKKLPVHLGKATS

CYP125D1 Rhodococcus sp. RHA1 Rha05286

VQLADVDLYNPDTFAKGVPHEMFAVLRREAPVYRHLDERGDPFWCVTRHADIVTVNRDAETYSSWRGATYIDDLSPDDLAGQQLMMLNMDPPDHTALRKIVSKGFTPRRIGQLHEILARRATTIVDAVIERGECDFVVDVASELPLQAIADFLGVPQEDRKLIFDLTNQMIGSSDPEF
HLEDGQERAAAAQMFAYSLEMFEDRKKHPRDDIATALIQADVHGEKLGELDFNMFFMLLAVAGNETTRNAISHTQLALMEHPEERRKVLEDPSKLDALIEEGLRWATPVMQFRRTATTDTVLHDVEISEGDRVVIWHMSGNRDEAVFDDPYTFDIDRPTGHYSQHIAFGGGGHHFC
LGANLARAEMKVMLSEILRRMPDMEQTAPAQRLRSNFINGLKHMPVTFTPSSL

CYP125E1 Sorangium cellulosum So Ce56 (myxobacterium) sce_040811_7184

MTPQTVDILD PDLYLAGAPH DRFELLRREA PVHWHPEPAG RGFWAITRHA DVARISRDPA
AFCSGRGLFI EDLPPGDMRD NPDVMIMMDP PRHARFRALV SKGFTPRVIQ RLESHVRELV
TRLIDDACER GGCDFASDIA GKLPLSVILE VIGVPREDQE QMLDWTTRFF GASDPAYGVT
PEELNAVLHN MNAYAHQLAE QRRKEPKDDM LSLLMAAEVD GEKLSYTEFG GFFNLLLTAG
HDTTKNLISN GMLALLEHPD QRRRLLDDPS LLPTAIEEML RFTPPVYYFR RSAVRDIELH
GQRIAAGDKV VLWYVSANRD ETVFSDPHRF DVGRTPNEHL SFGIGPHVCL GLVLARLEAR
VAFEELLRRL PDLELAGPAV RLRSNWVSGV KSMPVRCARP AR

CYP125F1 Mycobacterium avium subsp. paratuberculosis str.

MRTPVTVGQHRHPFGRDIYVGRSGYVTEDAISIGGVNLADPDTY
RAGMPYGAFRKLRERAPVAWHPQKDGSGFWALTGYEEIHAVSRDSATWSSQINGAMFD
APPPGEVPPVMIFMDPPQHTALRKLINKGFTPRQVTRLNEHIVEMAKQIVDDVIERGE
CEFADDVAGALPSYVIAEMLGIPLEDGRRLYQITEILHTGSVGDSDDERQQAMVEMFQ
YGVELAVRKRAEPGDDIATSLLHAEVDGQSLSDLEFNLFFMLLIDAGGDTTRNLVAAG
ILALLEHPQELQRLKADPSLMPTAIEEMLRYTSPVTAFLRTATKDTELRGVPVKAGER
VAMFYPSGNRDDSHFADPDRLDVGRAPNPHLAFGGGGTHFCLGANLARVEASAMVPEV
LSRMNDLELAGPVERLRSDLINGIRSMPVRFTPGKRLGTA

CYP125F2 Mycobacterium vanbaalenii PYR-1

MATDAISIGGVDLADPDTYVGGMPHGAFRELRRHAPVAWHPYGDNPGFWALTGYDEVLAVSRDSRTWSSQ
TTGVFLDVPAPEDSYQLSLMMLTMDPPRHTALRALVSRGFTPRHLARLNARTADMARDILDAALQRGECE
FVDDVAGALPSYVIAELLGIPLDDGRRLYALTEIMNTRPLHDPELMQTQVELFGYAGDLAASKRAAPGDD
IATALLHAEVDGQRLTDLEFNLFFMLLLNAGGDTTRNLVAAGTLALIEHPEQWARLAADPSLMPTAIEEM
LRWTSPVNVFTRTATRDTEVGGVPLRAGERVAMFYPSANRDEKHFADPDRFDIGRAPNHHLAFGGGGTHF
CLGASLARVEATAIFGEILTRTAHIELAGPVERVRSVLMNGIRSMPVRLTPASVPA

CYP125F3 Mycobacterium flavescens PYR-GCK

MQDRVDHPEY EVRRHEQNCG AQPLGEGHLV AQESAQVAEH AHYVNDYSRL CLQYRGANQT
GRSTVRPMPA DAITLGGADL ADPDTYLAGM PYDAFRTLRR EAPVAWHPQV DKPGFWALTG
YDEIYAVSRD SETWSSQATG VFLDVPAPED SYQLALMMLT MDPPRHTALR ALVSRGFTPR
HVARLGARTA DMARAIVDDA LAHGQCEFVD EVAGALPSYV IAELLGIPLE DGRRLYTLTD
IMNTRPLHDP ELVAAQMQMF EYAAELAARK RSEPGDDIAT ALLHAEVDGR RLTDLEFNLF
FLLLINAGGD TTRNLVAAGT LALIEHPDQW RRLAADPSLM PTAVEEMLRW TSPVTVFSRT
ATRDTDVGGI RLREGERVAM FYPSANRDEK HFADPDRFDI GRMPNPHLAF GGGGTHFCLG
ASLARVEAAA IFRELITRTR EIGLVGPVER VRSVLMNGIR SMPAQFTPAV VPA

CYP125G1 Salinispora tropica (marine actinomycete)

MSTEVVSTGNRADIAHPATYAAGVPYAEFARLRRDKPVSWVPEAALWRRSGEGRILSQGP
GFWAVTTHEGVVAASRQPEVFSSGRQGAFLADPRTTADLEQARQLLVNMDAPQHARVRKL
VTAVFTPRAIRALGDSVTAHARNLVERAVRQEECDVVADLAAELPLLVLADLLGLPREDR
HLLYQWSNNLVGFDDPEYGGGDVEAYRKTFFEAFQYALSVAGERRRAPREDLMTLLATSE
VDGRRLTDREFCNFWLLLVVAGNETTRHLITGSVLALVDNPMQRERLVADDTLLPSAVDE
LLRWVSPIMQFRRTAIVDTELCGTPIAAGDKVVLWYTSANRDAAVFEAPDELRLHRNPNP
HLSFGMGPHFCLGAHLARLEARTMLRELAPHLSRFRLTGPVVRLESNFVNGVKSLPGSFT
GQ

CYP126A1 Mycobacterium tuberculosis

MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEH
TPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPR
HTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICI
LLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA
DDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQL
QTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRD
PSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP
AEWTRSNRHTGIRHLVVELRGG

CYP126A1 Mycobacterium bovis subsp. bovis AF2122/97,

MTTAAGLSGIDLTDLDNFADGFPHHLFAIHRREAPVYWHRPTEH
TPDGEGFWSVATYAETLEVLRDPVTYSSVTGGQRRFGGTVLQDLPVAGQVLNMMDDPR
HTRIRRLVSSGLTPRMIRRVEDDLRRRARGLLDGVEPGAPFDFVVEIAAELPMQMICI
LLGVPETDRHWLFEAVEPGFDFRGSRRATMPRLNVEDAGSRLYTYALELIAGKRAEPA
DDMLSVVANATIDDPDAPALSDAELYLFFHLLFSAGAETTRNSIAGGLLALAENPDQL
QTLRSDFELLPTAIEEIVRWTSPSPSKRRTASRAVSLGGQPIEAGQKVVVWEGSANRD
PSVFDRADEFDITRKPNPHLGFGQGVHYCLGANLARLELRVLFEELLSRFGSVRVVEP
AEWTRSNRHTGIRHLVVELRGG

CYP126A2 Mycobacterium smegmatis

MRADLTDLDNFADGFPHALFEAHRREAPVYWHEPTEHTPDGEGFWSVATY
AETLAVLRDPVTFSSVTGGSRPYGGTLLQDLAIAGQVLNMMDDPRHAQIR
RLVSSGLTPRMIARVEEDLRVRARRLLDAVEPGVPLDFLVEVAAELPMQM
ICILLGVPESERHWLFHAIEPQFDFSGSRTASVGQLTPEEAGNRMYRYGM
ELIAAKRAAPTDDMLSVVANAHDAELSDLELYLFFSLLFSAGAETTRNAV
AGGLLALIEHPSQMALLRADLALLPTAVEEMVRWTSPSPSKRRTATRDVE
LGGCRIAAGDKVQIWEGSANRDPLVFTDPDVFDITRKPNPHLGFGQGVHY
CLGANLARLELRVLFEELLSRFSAARLVKPVEWTRSNRHTGIRHLVVEFDA

CYP126A3 Mycobacterium marinum MM4915

MTSAGVLSKI DFTDLDNFAD GFPHALFAIH RREAPVYWHE PTDNTPDGEG FWSVATYPET
LEVLRDPVTY SSVTGGQRPF GGTLLQDLAI AGQVLNMMDD PRHAQIRRLV SSGLTPRMIR
RVEDDLRART RRLLDAVVPG EPFDFLVDVA AELPMQMICI LLGVPESERH WLFEAIEPQF
DFGGSRKAAV SQLSVAQTAE EAASRMYSYG QELIASKRAA PTDDMLSVVA NAMVDGGDEP
ALSDLELYLF FSLLFSAGAE TTRNAVAGGL LALAEHPEQL RALRGDLDLL PTAVEEMVRW
TSPSPSKRRT ATRDVTLAGC SIEAGQKVQI WEGSANRDAR IFDHADEFDI TRKPNPHLGF
GQGVHYCLGA NLARLELRVL FEELLGRFGA VLVGQPVEWT RSNRHTGIRH LVVELFGG*

CYP126A3 Mycobacterium ulcerans

VTSAGVLSKIDFTDLDNFADGFPHALFAIHRREAPVYWHEPTDNTPDGEGFWSVATYPET
LEVLRDPVTYSSVTGGQRPFGGTLLQDLAIAGQVLNMMDDPRHAQIRRLVSSGLTPRMIR
RVEDDLRARTRRLLDAVVPGEPFDFLVDVAAELPMQMICILLGVPESERHWLFEAIEPQF
DFGGSRKAAVSQLSVAQTAEEAASRMYSYGQDLIASKRAAPTDDMLSVVANAMVDGGDEP
ALSDLELYLFFSLLFSAGAETTRNAVAGGLLALAEHPEQLRALRGDLDLLPTAVEEMVRW
TSPSPSKRRTATRDVTLAGCSIEAGQKVQIWEGSANRDARIFDHADEFDITRKPNPHLGF
GQGVHYCLGANLARLELRVLFEELLGRFGVVLVGQPVEWTRSNRHTGIRHLVVELFGG

CYP126A4 Mycobacterium vanbaalenii PYR-1

MRVAGALAAVDFTDLDNFAAGFPHGLFALHREQAPVYWHEPTENTPDGEGFWSVATHAETLAVFRDPETY
SSVTGGERAFGGTLLQDLPIAGQLLNMMDDPRHSAVRRLVSSGLTPRMIRRVEDDLRERARRLLDEVEPG
TPVDFLTDIAAEVPMQMICILLGVPESERHWLFEAIEPSFDFGGARKASITRLSVEEAGSRMFEYGQELI
AAKRAQPGDDMLSVVVNSGDPQLSDLESYLFFNLLFSAGAETTRNAIAGGLLALIENPDAYRALRADPGL
LPTAIEEMIRWTSPSPSKRRTATRRATLGGHTIEAGQKVLVWEGSANRDAAVFASPDHFDITRKPNPHLG
FGQGVHYCLGANLARLELRVIFEEILRRHPAAHLARPVEWTRSNRHTGIRHLVVEFASR

CYP126A5P Mycobacterium leprae

DRSLIPSAIEEGSRSETPNWASVTRITIA*LAIGGKTILPNAGVDILMGSANRDGSRWTE 363
364 PNTFDIHWPRQAHTTLAGSHMCLGIGLAQLDTRVMLNNLFD 486

CYP126B1 Saccharopolyspora erythraea NRRL23338

VTVDQPELPTSRNASESVSDQLPAVLGGFDLTDQVRFSGGFPHEVFNRLRADEPILLHPP
GRTRDGESFWVLSRYEDVVEAAANPVFSSQGGGSREGGGTHLDDLPAGTYAGGMLNMMDD
PRHQLIKDIVSPAVCPSAVAALEPVVRERASALVSTVLERGTCDLQAEVAGRYSVEVVAA
LLGVPRQDWSRLVDWAEIAMGYEDRDEGEATGRSQAALLDMYKYGCELVRAKRAEPAGDF
MSLIATGEIPEGHGQAPLVDYEREVFFNLISLAGTEPTRNAIAIGLLALVEHPEQWQALR
ADRSLLDGAVEEALRWSSPTPYNRRTATEDIRFRDVLIREGDKVTLWWASANRDERVFAD
PFRFDVRRSPNPHLAFGHGAHTCLGPALARMELRVLLEELLDRVERIELTGPVPWARNSK
HTVALRVPVALTASS

CYP127A1 Rhizobium sp.

MSDLRRKRVKTNPIPDHVPPALVRHFSLFTSPGMAPTPNGDPHA
AVACVHDDGPPIFYSPSNTRDGRGTWVITRARDQRRVLEDTETFSSHRSIFASALGEH
WPVIPLELDPPAHGVFRALLNPLFSSRRVLALEPTIHARAGALIDCIAKEKTSCDVMK
DFALPFTFSVFLSFLGLSQRRSEVLVGWVSDLLHGNAEKRRAAARSVVAFIDEMAAMR
RKSPAVDFMTFVVQAKIEGRSLTEEEVRGIGVLFLVAGLDTVAAAIGFDMAYLARNPK
HQELLRNEPARLGLAAEELLRAYSTVQIIRVATKDIEFEGVPIREGDYVSCPAMIANR
DPSEFKCPNTIDLARQDNQHTAFGYGPHLCHGAHLARREIVIGLREWLARIPAFRIKE
GTAPITHGGHVFGISNIILTWA

CYP127A2 Rhizobium sp. BR816

MILRRNHVALKPVPDHVPPEMVRDFSLFTSPGMQRMPNGDPHAA
VARVHGGPPIFYSPDNTRDSRGTWVITRAKDQRRVLQDSESFSSHRSIFASALGENWP
MIPLELDPPAHGVFRSLLNPLFSPKRVMALEPAIRQRAMALIDRICASRTSCDVMSDF
AFPFAVNIFLRFLGLSDERLDTYVGWGKDLLHGDSVKRTAAALAIVAFIDELAAMRRK
EPTDDVMTFVVETEVDGRRLTDEEVRGIGVLVFVAGLDTVATAIGFDLAHLARNPNDQ
ALLRGEPDRIVPAVEELLRAYSTVQIIRVARKNIDFEGAPIRKGDYISCATMIANRDP
AEFECPNTIDLAREDNRHTAFAYGPHRCLGSHLARREIVIGLEEWLSRIPDFRIKEGT
APITFGGHVFGIENLILDWS

CYP127A3v1 Mesorhizobium loti

1 MAINPVPDHV PPEMVRDFSL FTSPGMPPTP NGDPHAAVAC AHDGPPIFYS PYNTQDGRGT
61 WVITRAADQR KVLQDTETFS SHRSIFSSIL GETWPTIPLE LDPPAHGAFR SLLSPLLSPK
121 RVTALEPAVR ERAIALIDRI TASATSCDVM KDFAFPFTVS IFLRFLGLPD QGLDTFVGWA
181 KDLLHGDDVE RPVAARKIVA FIDELATNRR KDPVDDLMTF IVQAQIEGRR LTDGEIRGIG
241 VLVFVAGLDT VAAAIGFDLA YLARNLKDQE LLRSEPARIL LATEELLRAY PPIQLIRVAT
301 KDIDFEGAPI RKGDYVSCAT MIANRDPEEF ESPNTVDLAR DHNRHAAFGY GPHRCLGSHL
361 ARREIVIGLE EWLARIPTFR IKEGTAPITC GGHVFGIENL ILDWS

CYP127A3v2 Mesorhizobium loti

GenEMBL AL672114 complement(100678..101895)
Strain R7A symbiosis island
Gene = msi332
2 DIFFS with CYP127A3v1

CYP127A4 Rhizobium etli symbiotic plasmid p42d

MHLCSERIYRKRGTRENPMSTGRAGEASKKFRLRPTKQRGFRAA
RRSDRCIACHWRLALLRLEIWRSTILLAPSPRRIRSRRRGFDDRRKAVATIRVPEHVP
PEMVKDFSLFTSPGMERMPNGDPHAAVACLHNGPRIFYSPCNTRDGRGTWVIVRAQDQ
RKLLQDTGTFSSHRSLFASALGENWPLIPLELDPPAHSVFRSLLNPLLSPRRIMELEP
AVRDRAIALISKISASSTSCDILTDFAFPFAVSIFLRLLGLSDERLNTFVGWGKDLLH
GDGIRRTAAARTILAFIDELAAMRRKEPADDFMTFVVQAKVDGRLLRDQEIHGIGVLL
FVAGLDTVATAIGFDLAYLARNPTEQELLRSKPDRIVLAAEELLRAYSTVQMIRVATK
DINFEGAPIRKGDYISCATMIANRDPVEFENPNTIDLAREDNRHTAFAYGPHRCLGSH
LARREIIIGLEEWLSRIPDFRIKDGTAPITYGGHVFGMENLILDWS

CYP128A1 Mycobacterium tuberculosis

MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTR
RRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDF
DPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVT
FSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPAD
VVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGF
RRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMI
STLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPA
GSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILR
EIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP

CYP128A1 Mycobacterium bovis subsp. bovis AF2122/97,

MTATQSPPEPAPDRVRLAGCPLAGTPDVGLTAQDATTALGVPTR
RRASSGGIPVATSMWRDAQTVRTYGPAVAKALALRVAGKARSRLTGRHCRKFMQLTDF
DPFDPAIAADPYPHYRELLAGERVQYNPKRDVYILSRYADVREAARNHDTLSSARGVT
FSRGWLPFLPTSDPPAHTRMRKQLAPGMARGALETWRPMVDQLARELVGGLLTQTPAD
VVSTVAAPMPMRAITSVLGVDGPDEAAFCRLSNQAVRITDVALSASGLISLVQGFAGF
RRLRALFTHRRDNGLLRECTVLGKLATHAEQGRLSDDELFFFAVLLLVAGYESTAHMI
STLFLTLADYPDQLTLLAQQPDLIPSAIEEHLRFISPIQNICRTTRVDYSVGQAVIPA
GSLVLLAWGAANRDPRQYEDPDVFRADRNPVGHLAFGSGIHLCPGTQLARMEGQAILR
EIVANIDRIEVVEPPTWTTNANLRGLTRLRVAVTPRVAP

CYP129A1 Steptomyces sp.

MSGEAPRVAVDPFSCPMMTMQRKPEVHDAFREAGPVVEVNAPAG
GPAWVITDDALAREVLADPRFVKDPDLAPTAWRGVDDGLDIPVPELRPFTLIAVDGED
HRRLRRIHAPAFNPRRLAERTDRIAAIADRLLTELADSSDRSGEPAELIGGFAYHFPL
LVICELLGVPVTDPAMAREAVGVLKALGLGGPQSAGGDGTDPAGDVPDTSALESLLLE
AVHAARRKDTRTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAE
VLAGRLAADADGDAISRFVEEALRHHPPVPYTLWRFAATEVVIRGVRLPRGAPVLVDI
EGTNTDGRHHDAPHAFHPDRPSRRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPQ
ARLAVPYEELRWCRKGAQTARLTDLPVWLR

CYP129A2 Streptomyces peucetius

MAVDPFACPMMTMQRKPEVHDAFREAGPVVEVNAPAGGPAWVIT
DDALAREVLADPRFVKDPDLAPAAWRGVDDGLDIPVPELRPFTLIAVDGEAHRRLRRI
HAPAFNPRRLAERTDRIAAIAGRLLTELADASGRSGKPAELIGGFAYHFPLLVICELL
GVPVTDPAMAREAVSVLKALGLGGPQSGGGDGTDPAGGVPDTSALESLLLEAVHSARR
NDTPTMTRVLYERAQAEFGSVSDDQLVYMITGLIFAGHDTTGSFLGFLLAEVLAGRLA
ADADEDAVSRFVEEALRYHPPVPYTLWRFAATEVTIGGVRLPRGAPVLVDIEGTNTDG
RHHDAPHAFHPDRPSWRRLTFGDGPHYCIGEQLAQLESRTMIGVLRSRFPEARLAVPY
DELRWCRKGAQTARLTELPVWLR

CYP130A1 Mycobacterium tuberculosis

MTSVMSHEFQLATAETWPNPWPMYRALRDHDPVHHVVPPQRPEY
DYYVLSRHADVWSAARDHQTFSSAQGLTVNYGELEMIGLHDTPPMVMQDPPVHTEFRK
LVSRGFTPRQVETVEPTVRKFVVERLEKLRANGGGDIVTELFKPLPSMVVAHYLGVPE
EDWTQFDGWTQAIVAANAVDGATTGALDAVGSMMAYFTGLIERRRTEPADDAISHLVA
AGVGADGDTAGTLSILAFTFTMVTGGNDTVTGMLGGSMPLLHRRPDQRRLLLDDPEGI
PDAVEELLRLTSPVQGLARTTTRDVTIGDTTIPAGRRVLLLYGSANRDERQYGPDAAE
LDVTRCPRNILTFSHGAHHCLGAAAARMQCRVALTELLARCPDFEVAESRIVWSGGSY
VRRPLSVPFRVTS

CYP130A1X Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome
CYP130 lies in a deletion in M. bovis

CYP130A2 Mycobacterium smegmatis

MSHPAVAFELANADTWADPWDMYTALRDHDPVHHVVPPERPHHDYF
VLSRHADIWAAARDHETYSSAQGLTVNYGELELIGLADNPPFVMQDPPTH
TEFRKLVSRGFTPRQVEAVEPQVREFVVERLERLRAEGGGDIVAELFKPL
PSMVVAHYLGVPEADRAQFDGWTEAIVAANSEAGSALGAGDAVMSMTGYF
AELIERRRREPGDDTISHLVAAGADDEAVDVLSILAFTFTMVTGGNDTTT
GMLGGAVQLLQQHPDQRRVLTDDPDLIPDAVDEFLRLTSPVQGLARTATR
DVTIGDTTIPAGRKVLLLYGSGNRDEREFGPDAAQLDVRRRPRNILTFSH
GAHFCLGAAAARMQSRVALTELLTRCPDFTVDLDAVVWAGGSYVRRPLSV
PFRAGA

CYP130A3 Rhodococcus sp. RHA1 Rha08652

MGNVSHYRYMTAHVSSVSFVPRSGQSWRAPWQMYAGLRDHDPVHHVVPEDAPGNDYWVLSRHADVYAAARDPETFSSAAGLTTTYGELEKIGLQDNPPLVMLDPPDHTAFRRLVSKGFTPRQVTAVEPNVRAFVVERIERLREAGAGDVVKELFKPLPSMVVAHYLGVPDEDRA
QFDGWTEAIVAANAQGDTLQATGAVTELMGYFTGLIERRRTDPGDDTISHLVAGGMGADGDITGLLSILGFAFTMVTGGNDTTTGMLGGAVQLLTEHRDQRRDLIEHPELVRDAVEELLRLTAPVQGLARTVTRDVEIEGTVVPEGRKVLLLYGSANRDPRRFGPDAEVLDVRRSPK
QILTFSHGAHHCLGAAAARMQARIALEELLARCPDFTVDIDAVVYADGNYVRRPTSVPFRVREA

CYP130A4 Mycobacterium marinum MM4184

MSVDVSHRAP VAFQLATAAT WPDPWPMYRA LRDQDPVHHV IPAHQPDQDY YVLSRHADVW
AAARDHQTFS SAQGLTVNYG DLEMIGLQDN PPMVMQDPPA HTEFRKLVSR GFTPRQVEAV
EPKVRDFVVE RIERLRAQGG GDIVTELFKP LPSMVVAHYL GVPEQDRTQF DGWTQAIVAA
NTAEGGIAGA LATVGDAVGS MMAYFTSLIE RRRAKPEDDT ISHLVAAGVG ADGDIAGTLS
ILAFTFTMVT GGNDTVTGML GGSMPLLHRR PDQRRLLTDN PELITDAVEE LLRLTSPVQG
LARTVTHDVT IGNVTIPAGR RALLLYGSAN RDERQYGPDA GELDVRRCPR NILTFSHGAH
HCLGAAAARM QSRVALTELL ARCPDFEVDE SRIVWSGGSY VRRPLSLPFE VRS*

CYP130A4P Mycobacterium ulcerans

MSHRAPVAFQLATAATWPDPWPMYRALRDQDPVHHVIPTHQPDQDYYVLSRHADVWAAAR
DHQTFSSAQGLTVNYGDLEMIGLQDNPPMVMQDPPAHTEFRKLVSRGFTPRQVEAVEPKV
RDFVVERIERLRAQGAATSSPTCSSPCRRWWSHTISGYPNRTGHSSMGGPRPSSRPTPPR
AASRARWPRSAMWSGR*LSSMVVAHYLGVPEQDRAQFDGWTQAIVAANTAEGGIAGALAT
VGDVVGSMMAYFTSLIERRRAKPEDDTISHLVAAGVGADGDIAGTLSILAFTFTMITGGN
DTVTGMFGGSMPLLHRRPDQRRLLTDNPELITDAVEELLRLTSPVRGLARTVTHDVTIGN
VTIPAGRRALLLYGSANRDERQYGPDAGELDVRRCPRNILTFSHGAHHCLGAAAARMQSR
VALTELLARCPDFEVDESRIVWSGGSYVRRPLSLPFEVRS

CYP130A5 Mycobacterium vanbaalenii PYR-1

MTAVLSHGSPVHFALADASTWADPWPMYRALRDHDPVHHVVPEDRPNHDYYVLSRHADIWAAARDHQTFS
SALGLTVNYGELDLIGLADNPPMVMQDPPVHTEFRKLVARGFTPRQVEAVEPKVHDFVVDRIEHLRANGG
GDIVAELFKPLPSMVVAHYLGVPDEDRGKFDGWTDAIVAANTSAGGLGGALDTLGDALGEMMSYFTALIE
RRRTEPEDDTISHLVAAGVGADGDISGVLSILAFTFTMVTGGNDTTTGMLGGSVQLLHRRPDQRTMLAEN
PDLIPDAVDEFLRLTSPVQMLGRTVTHDVTIGDVTIPEGRRVMFLYGSGNRDERQYGDDAGELDVTRKPR
NILTFSHGAHHCLGAAAARMQSRVALTELLTRIPDFEVDESGIAWAGGSYVRRPVSVPFTVTH

CYP130A6P Mycobacterium leprae strain TN

VMSHRFRFTTADIWPNPWSMYRTLRDHEAVHHVVPANQPEDDYYVLPRHADVWSMAMRS
HAKLSSAQRLTVNYSDMELIGLQDNPPMVMQDQPV*TKCRKLVSRRFTPRQTNVVEPKVR
HFVVEHIEQLRAKGSVDIVTELFKPLPPMVVAHYFGFPEKVRSQFDGW
TTAADGGGALFRFPRKSPITIRRLAPAIVAANTADAGGITNELDVAGYAVESMLAYFTR
IATGGNNTVTGMLGG*MPL
SHRRKQHRHWHARRLDAVKDTAEAD
LLRLTSSVRGLMRTTTRDVAIGHTTVSPGRRVLMRYGQAKRDER*YSAAAS*LDVTW*
PPNILIFSHGAH
YLGAKVTRMQRR
VRLTELLARYPDFEVDESSIAWAGGKLHTTP

CYP131A1 Streptomyces peucetius

MPTPTSAPPAAPTDSELGRHLLTVRGFHFVFGALGDPYARRLRG
EADHLSLGELVRDRGPLHGSALGTWVTADGGISARLLDDPLLGPRHPASEGPQEHVLE
NVWETWRTCHVTPLGEDLLTPAAADSDRLAALLGPVLGPRTCTAWQVDAGRAVHRVLD
GLPPHFDVVSDLARPAIAGSLAAVLGLPDEARAELPDLLAACGPVLDSALCPPRLPVA
RAMTQALRRVRELMAAAVANHLTAPADGAVSALLAVDPGGGRDPGDTVTAAVLSTVVG
AETAITTVANAVMALLKHDEQWSLLRADPGRAADAVEETLRWAPPVTLRSLITQGEVQ
IGGETLEADQHVVVLVDAAQRDPALYEDPDRFRLDRPRSPGFTHMALAGRDHLGLVAP
LVRVQCTAVLRALAERLPGLRAEGEPLRRGRSPVVRAPLSLRLAQK

CYP131A2 Streptomyces sp.

MTMPTPTSAPPAAPTNSELGRHLLTVRGFHFVFGALGDPYARRL
RGEADHLSLGELVRDRGPLHRSALGTWVTADGETSAGLLDDPLLGPRHPASEGLQ

CYP132A1 Mycobacterium tuberculosis

MATATTQRPLKGPAKRMSTWTMTREAITIGFDAGDGFLGRLRGS
DITRFRCAGRRFVSISHPDYVDHVLHEARLKYVKSDEYGPIRATAGLNLLTDEGDSWA
RHRGALNSTFARRHLRGLVGLMIDPIADVTAARVPGAQFDMHQSMVETTLRVVANALF
SQDFGPLVQSMHDLATRGLRRAEKLERLGLWGLMPRTVYDTLIWCIYSGVHLPPPLRE
MQEITLTLDRAINSVIDRRLAEPTNSADLLNVLLSADGGIWPRQRVRDEALTFMLAGH
ETTANAMSWFWYLMALNPQARDHMLTELDDVLGMRRPTADDLGKLAWTTACLQESQRY
FSSVWIIAREAVDDDIIDGHRIRRGTTVVIPIHHIHHDPRWWPDPDRFDPGRFLRCPT
DRPRCAYLPFGGGRRICIGQSFALMEMVLMAAIMSQHFTFDLAPGYHVELEATLTLRP
KHGVHVIGRRR

CYP132A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(1566263..1567648)
Gene = CYP132 1 aa diff
locus_tag = Mb1429c

CYP133A1 Erwinia herbicola

MQLHELMDPDYSDNPFPLYRKLHQQGPLIPAGDKIIISGSHAVVDALLNDRRVGKNYMESVRVRFGDDAAGLPLFQGISRMFLVLNPPDHNRL

CYP133B1v1 Xylella fastidiosa 9a5c

1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYMES
61 MRVRYGDSAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG IAVSKIAKVF DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

CYP133B1v2 Xylella fastidiosa Temecula1

1 MKLTDLSNPA FLENPYPLYE TLRAQAPFVS IGPNALMTGR YSLVDSLLHN RNMGKKYIES
61 IRLRYGDTAA DMPLFQAFSR MFITINPPAH THLRGLVMQA FTGRESESMR PLAIDTAHQL
121 IDNFEQKPSV DLVAEFAFPF PMQIICKMMD VDIGDAVTLG MAVSKIAKVL DPSPMSADEL
181 VHASTAYEEL AQYFTKLIEL RRTHPGTDLI SMFLRAEEDG EKLTHDEIVS NVIMLLIAGY
241 ETTSNMIGNA LIALHRHPEQ LALLKSDLSL MPQAVSECLR YDGSVQFTMR AAMDDIEVEG
301 ELVPRGTVVF LMLGAANRDP AQFTHPDQLD ITRKQGRLQS FGAGIHHCLG YRLALIELEC
361 ALTTLFERLP HLRLAHLDAL NWNQRSNLRG VNTLIVDLHA KN

CYP133B1v3 Xylella fastidiosa Dixon

MKLTDLSNPAILENPYPLYETLRAQAPFVSIGPNALMTGRYSLV
DSLLHNRNMGKNYMESMRVRYGDSAADMPLFQAFNRMFITINPPAHTHLRGLVMQAFT
GRESESMRPLVIDTAHQLIDNFEQKPSVDLVAEFAFPFPMQIICKMMDVDIGDAVTLG
MAVSKIAKVFDPSPMSADELVHASTAYEELAQYFTKLIELRRTHPGTDLISMFLRAEE
DGEKLTHDEIVSNVIMLLIAGYETTSNMIGNALIALHRHPEQLTLLKSDLSLMPQAVS
ECLRYDGSVQFTMRAAMDDIEVEGELVPRGTVVFLMLGAANRDPAQFTHPDQLDITRK
QGRLQSFGAGIHHCLGYRLALIELECALTALFERLPHLRLAHLDALNWNQRSNLRGVN
TLIVDLHAKN

CYP133B2v1 Xylella fastidiosa, section 33 of 22

AE003887 CDS 6723..7925
82% to AE003889 48% to CYP133A1

CYP133B2v2 Xylella fastidiosa Ann-1

MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLATDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMDVDISDAISLS
VAVSNIAKVFDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLSGYETASNMIGNALIALHRHPKQLARLKSDLSLMPQTVL
ECLRYDGSVQFTVRAAMDDVSIEGDVVPRGTIVFLMLGAANRDPAQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP

CYP133B2v3 Xylella fastidiosa Dixon

MKLADLSSPAFLENPYPLYETLRRQGPFVSIGPNALMTGRYSIV
DGLLHNRNMGKSYMESIRVRYGDDALDMPLFQGFNRMFLMLNPPVHTHLRGLVMQAFT
GRESESMRPLAIDTAHRLIDDFEQKSSVDLVTEFSFPLPMRIICRMMHVDISDAISLS
VAVSNLAKVLDPAPMSPDELVHASAAYEELAHYFTRLIELRRAQPGTDLISMLLRAEE
EGQKLTHDEIVSNVILLLLGGYETTSNMIGNALIALHRHPKQLARLKSDLSLMPQAVL
ECLRYDGSVQFTIRAAIDDVSIEGDVVPRGTIVFLMLGAANRDPVQFTDPDHLEITRK
QGRLQSFGAGVHHCLGYRLALVELECALTVLLERLPHLRLANLDTLSWNQRGNLRGVN
ALIADLHP

CYP133B3 Xanthomonas axonopodis pv. citri str. 306

1 MLLSDLATPQ FRHDPYPTYA RLREEGPLVQ VADGRLMSGR YAVVDRLLSD RRVGRDYLQS
61 VRLRYGEAAV HLPLFQGMSR MFLLLNPPLH TQLRGLMTQA FGARQMESMR EVASDIAAGL
121 IDAFQANGHC DLLTEFAFPL PIAIICRMLD IAAADVTALS HATSALAKVF DPMMTAEELQ
181 ATSVAYDQLA TYFHGVIAQR RSAGGDDLIA RFIQAEDNGR RLSEEEIVSN VILLFFAGHE
241 TTSNMICNAL VALHRHPQQL RLLQETPGLL PNAVLECMRY DSSVQMATRT ALQDFEIEGV
301 AVPRGTMLYL MLGAANHDTL QFTDPQVLDI RRQQGRALSL GGGIHHCLGN RLALIEVEAA
361 LACLLARLPA LRLEQLDTLS WNDRANLRGV DALLASW

CYP133B4 Xanthomonas campestris pv. Campestris str. ATCC 33913

1 MQLSDFATPA FRQDPYPMYA RLRAAGPLVQ ISDNGWVSGH YTVVDALLSD RRVGRNYLDS
61 IRVRYGANAA EMPLFQGMSR MFLLLNPPVH TQQRALMTKA FGARQLEALR EVAVDTADAL
121 LDQHEDRRSC DLLNDFAMPM TISLICRMLG LAVTDVAALG QASSALAKVF DPLMRPEDMA
181 QATAAYTTLE QYFRAIVLQR RDTQEDDLIA RLIAAEDHGQ RMPVDDIVSN VIMLFTAGHE
241 TTANMICNAL IALHRHPEQL QLLRDTPTLM PNAVLECMRY DSSVQVAMRS VLQPLQVEGT
301 TLPVGAILYL MLGSANHDAE QFTAPQQLDL RRQQGRALSF GGGVHHCLGN RLALIELETA
361 LERLLQRAPA LRLPELDNLS WNERANLRGI QALHATW

CYP133B5 Ralstonia solanacearum GMI1000 megaplasmid

MKLADLSTPSFLENPYPLYETLRSQGPFVRIGPNALMTGHYSIV
DALLHNRQMGKSYMESIRLRYGDEGPNMPLFQGFSRMFLMLNPPMHTRLRGLMMQVFN
ARQIESMREVATATAHQLIDDFEQKPSADLVAEFAFPLPVRIICQMMDLDIDDAMALG
VGVSKLAKVFDPAPMSADALVETSAAYEELAQYFTKVIEARRAQPGTDLISMLMRAEE
NGETLTHDEIVSNVILLFIAGHETTSNMIGNALIALHRNPQQLDLLKREPSRMPNAVL
ECLRYDGSVQVTIRAALEDVEVEGEVLPRGTTVFLMLGAANRDPAQFTDPDQLDIGRQ
QGRLQTFGAGIHHCLGYRLALIELESALGALFERLPNLRLTNLDQLSWNQRGNLRGVN
ALMAAW

CYP134A1 Bacillus subtilis

MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS
RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD
HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG
VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL
SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY
KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK
SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT
RGPVSLLVAFDGA

CYP134A2P Bacillus cereus ATCC 14579

1 MIGATNCDSN VFERPDKFNV YRPDIDIKKA FSGTARHLAF GLSIYNCVGV AFAKLKIEID
61 STIKDNISRK KLRDIKDFVK KTSKMN

CYP134B1 Photorhabdus luminescens subsp. laumondii TTO1

MAKLSSFNIHDPKFIKNPYDFYDILHKQDLVYFEQSQNSYFIGK
YEDVDAILKSSIFNTKPLTALAEPVMGDRVLAQMEGEEHACKRKFIMQGLSRDYFNRY
YEPMIRKITEDLLQPYMEKGNIDIVNDFGRDYAVLVTLSILGLPSDNYRDIAEWHKGI
ASFITQFDQTELEKMHSLECSQKLIRLLKPIIDQRRRNPSKDIISIFCQDTAMSMSEI
TALCLNILLAATEPADKILAMMLNHLISNPSMLDVVLKDRSLVRDAFEETLRLTSPVQ
LIPREASEDVTISGIDIPKGAVVFCMIGAANRDPSVFHKPNEFDLYRRKNTTSPQKAN
RKRHLAFGAGTHACAAAAFSLSQLEVSSNIILDLLHNLRFADHYHYQETGVYTRGPSK
LLLSFDPIASSAIKE

CYP135A1 Mycobacterium tuberculosis

MASTLTTGLPPGPRLPRYLQSVLYLRFREWFLPAMHRKYGDVFS
LRVPPYADNLVVYTRPEHIKEIFAADPRSLHAGEGNHILGFVMGEHSVLMTDEAEHAR
MRSLLMPAFTRAALRGYRDMIASVAREHITRWRPHATINSLDHMNALTLDIILRVVFG
VTDPKVKAELTSRLQQIINIHPAILAGVPYPSLKRMNPWKRFFHNQTKIDEILYREIA
SRRIDSDLTARTDVLSRLLQTKDTPTKPLTDAELRDQLITLLLAGHETTAAALSWTLW
ELAHAPEIQSQVVWAAVGGDDGFLEAVLKEGMRRHTVIASTARKVTAPAEIGGWRLPA
GTVVNTSILLAHASEVSHPKPTEFRPSRFLDGSVAPNTWLPFGGGVRRCLGFGFALTE
GAVILQEIFRRFTITAAGPSKGETPLVRNITTVPKHGAHLRLIPQRRLGGLGDSDPP

CYP135A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(393726..395075)
Gene = CYP135A1 1 aa diff
locus_tag = Mb0334c

CYP135B1 Mycobacterium tuberculosis

MSGTSSMGLPPGPRLSGSVQAVLMLRHGLRFLTACQRRYGSVFT
LHVAGFGHMVYLSDPAAIKTVFAGNPSVFHAGEANSMLAGLLGDSSLLLIDDDVHRDR
RRLMSPPFHRDAVARQAGPIAEIAAANIAGWPMAKAFAVAPKMSEITLEVILRTVIGA
SDPVRLAALRKVMPRLLNVGPWATLALANPSLLNNRLWSRLRRRIEEADALLYAEIAD
RRADPDLAARTDTLAMLVRAADEDGRTMTERELRDQLITLLVAGHDTTATGLSWALER
LTRHPVTLAKAVQAADASAAGDPAGDEYLDAVAKETLRIRPVVYDVGRVLTEAVEVAG
YRLPAGVMVVPAIGLVHASAQLYPDPERFDPDRMVGATLSPTTWLPFGGGNRRCLGAT
FAMVEMRVVLREILRRVELSTTTTSGERPKLKHVIMVPHRGARIRVRATRDVSATSQA
TAQGAGCPAARGGGPSRAVGSQ

CYP135B1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome 660693..662111
Gene = CYP135B1 100% match
locus_tag = Mb0583

CYP135B2 Mycobacterium smegmatis

MSTPGTLPPGPPLPAFVQTAMMLRHWSRFVSACRRRYGDVFTLRIASMGT
WVYLADPADIKTVFAGDPTVFHAGEANSMLSGLLGETSVLVIDEDVHRDR
RRLMLAPFARDAVARQTGVMAEVAATNIASWPVGTPFPVAPKMAEIALEV
ILRTVIGATEPARLAALRHVMPQLLGIGPWQSLAIASPGLQRRRPWRTLQ
RNLAEADRLLYAEIAACRAGPDLASRPDALAMLVRAANDEGRTMTDRELR
DQLMTLLVAGHETTATGLSWTLERLIRHPAVLDKAVAAARTTDGSGEAYL
DAVVRESLRIRPVVFEAGRVLTEPVELGGYLLPAGTLVAPSIGLVHASAD
VYPDPDRFEPDRMLASTQAPSTWLPFGGGNRRCLGATFALVEMRVVLREI
LHRVDLFATTARGEKQRLKHVTMIPHRGGRICVRALRDVAPAPMTCPAEA
RRA

CYP135B3 Mycobacterium marinum MM4483

MKGNAYDVTT MIARTRTALP PGPRLPRSVQ DALLIRHGPR FLAACRRRYG DVFTLRVASI
GTMVYVADPA VIKSVFAGDP NTLHGGAASM LRGLLGDSSL LVVDDRAHRD RRRLMLAPFH
RDVIERQAGL IAEIAAENVT GWPVGTPFAA ATKMSEITLE VILRTVIGTS DAARLAALRA
VMPRLLDLRP WETLALAKPN LLQRGPWRSL HRRIAEADEL LYAEIAEHRT DPGLSGRADT
LAMLIQAAYD DGRTMADGEL RDQLMTLLVA GHDNTAAGLC WALERLTRHP AVLAKAVQAA
DASAAGDPAG NEYLDAVVKE TLRARPVVFD LGRVLRKPIE LAGYLLPEGV MVVPSIGLVH
GSAALYPGPE RFDPDRMLGV ILGPTGWLPF GGGSRRCLGA AFAMAEMRVV LREILRRVEL
CPTTAVDERQ KLKNVILVPH RGGRILVRAM RGVPAPD*

CYP135B4 Mycobacterium marinum MM0938

MTKTATLPPG PRLPRAVQAA LMLRHAPRFL TACKRRYGSV FTLRVAGLGT MVNVTDPVVI
KKVFAGDPRV FHAGEANTML AGLLGESSLL VVDDDVHRDR RRMMLPPFQR EAVAHQAQLM
SEIAAENIAG WPVGRTFAVA PKMAEITLEV ILRTVIGATD PDRLAALRKV MPRLLNVGPW
ETLALAKPDL LSRRAWRRLR RAIDEANELL YAEIAERRAD PNLAERTDVL ATLVRAVDGD
TAKPSGRMTD EELRDQLMTL LVAGHDTTAT GLAWALERLT RHPAILAKAV RAAEASAAGD
PSGDEYLDAL AKETLRIRPV VFDVGRILTE PTELAGYQLP AGTMVVASIG LVHANAEVYP
DPDRFDPDRM IDATLTPTTW LPFGGGNRRC LGATFAMVEM RVVLREILRR VDLATTTAPD
ERYKLKHVIL VPHRDARIRV RAITAVSPAV PEAPGCPVAH AKS*

CYP135B5 Mycobacterium vanbaalenii PYR-1

MRDPRYGRGRAFYAGVMTPTSLPPGPRLPRSVQAALMLRCGPRFVAACRRRYGSAFTLRVASMGTLVYLT
DPADIKTVFAGDPDIYHAGEANSMLKGLLGDTSVLVIDGDLHRDRRRLMLAPFARDAVAAQAGVIAEIAA
DNIAGWPVGETFPVAPKMSEITLEVILRTVIGASDQARLAALRTVMPRVLSVGPWETLAIANQDLLRRRP
WRAVRDAIAEADRLLYAEIADRRADPDLDTRTDALAMLVRAGDMSDKELRDQLITLLVAGHDTTATALSW
ALERLTRHPAVLAKAVRAARDGDDDYLDAVAKETLRDRPVVFDVGRVLKAPVELAGYRLPAGVMVIPGLV
AVHADSQIYPHADRFDPDRMLGATLSPSSYLPFGGGNRRCLGATFAMVEFKVVLREILRRVELETTTARG
EHRRLKHVIFVPHRGARIRVRAKRVVAAEAPKCPMSGPA

CYP135B6 Mycobacterium marinum MM2978

MPHSNSGVLP PGPPLSRSLQ AALMLLRGPQ FLAACRRRYG DVFTLRIARM GTQVYLADPR
DIKTVFTGDT HIFHAGDANA LLSGLIGDSS LMVLDEEAHR CRRRTMLAPF HRDAVARQAG
LMAEIAADNV AGWPAGRTFP VTVRMSEITL EVILRTVIGA TDPARLAALR TAVPRLLSMG
PWGTLALANP KLLSRRPWRG LRKRIADVDN LLYAEITDRR NDAELGKRAD VLAMLIRTEG
NDNAMTDREL RDQLVTLLVA GYDTSATGLA WALERLTRHP TILTRAVAAA HASAAGDAAG
DEYLDAVVKE TLRIRPLAFA VGRVLAAPVE VAGYQLPAGA WALPGIGLVH ASAALYPDPD
RFDPDRMIGV SPGPTTWLPF GGGARRCLGA TFALVEMRVV LREVLRRAEL ITTTAADETP
KLKYVTLIPS RGARISVRTI KNIPPASPVG AEKPATTPGC PATENVGATR PAF*

CYP136A1 Mycobacterium tuberculosis

MATIHPPAYLLDQAKRRFTPSFNNFPGMSLVEHMLLNTKFPEKK
LAEPPPGSGLKPVVGDAGLPILGHMIEMLRGGPDYLMFLYKTKGPVVFGDSAVLPGVA
ALGPDAAQVIYSNRNKDYSQQGWVPVIGPFFHRGLMLLDFEEHMFHRRIMQEAFVRSR
LAGYLEQMDRVVSRVVADDWVVNDARFLVYPAMKALTLDIASMVFMGHEPGTDHELVT
KVNKAFTITTRAGNAVIRTSVPPFTWWRGLRARELLENYFTARVKERREASGNDLLTV
LCQTEDDDGNRFSDADIVNHMIFLMMAAHDTSTSTATTMAYQLAAHPEWQQRCRDESD
RHGDGPLDIESLEQLESLDLVMNESIRLVTPVQWAMRQTVRDTELLGYYLPKGTNVIA
YPGMNHRLPEIWTDPLTFDPERFTEPRNEHKRHRYAFTPFGGGVHKCIGMVFDQLEIK
TILHRLLRRYRLELSRPDYQPRWDYSAMPIPMDGMPIVLRPR

CYP136A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome 3376038..3377516
Gene = CYP136 1 aa diff
locus_tag = Mb3085

CYP136A1 Mycobacterium marinum MM1634

MATISTPAYL LDQAQRRLTP SFNNFPGMGM VERWLLKTQF PETTLADPPP GSDLKPVVGD
AGLPILGHLI EMLRGGPDYL MFLYRTKGPV VFGDSPVLPA VVALGPDAAQ VIYSNRNKDY
SQQGWVPVIG PFFRRGLMLL DFEEHMFHRR IMQEAFVRSR LVGYVEHMDE VASRAIAGEW
ATNDARFLLY PAMKKLTLDI ASMVFMGHEP GTDHELVTKV NRAFTTTTRA GNAVIRTSVP
PFTWWRGIRA RQLLENYFAA RVTERRGQEG NDLLTVLCHT ADEDGNRFSD QDIVNHMIFL
MMAAHDTSTS TATTMAYHLA AHPEWQQRCR DESDRLGDGP LDIEALEKLE SLDLVMNESI
RLVTPVQWAM RQTVRDTELL GYYLPKGTNV IAYPGMNHRL PEFWTDPMTF DPDRFAEPRN
EHKRHRYAFT PFGGGAHKCL GMVFGQLEIK TILHRLLRRY RLELARPDYR ACWDYGGMPV
PKDGMPIVLR PL*

CYP136A1 Mycobacterium ulcerans

VATISTPAYLLDQAQRRLTPSFNNFPGMGMVERWLLKTQFPETTLADPPPGSDLKPVVGD
AGLPILGHLIEMLRGGPDYLMFLYRTKGPVVFGDSPVLSAVVALGPDAAQVIYSNRNKDY
SQQGWVPVIGPFFRRGLMLLDFEEHMFHRRIMQQAFVRPRLVGYVEHMDEVASRAIAGEW
ATNDARFLLYPAMKKLTLDIASMVFMGHEPGTDHELVTKVNRAFTTTTRAGNAVIRTSVP
PFTWWRGIRARQLLENYFAARVTERRGQEGNDLLTVLCHTADEDGNRFSDQDIVNHMIFL
MMAAHDTSTSTATTMAYHLAAHPEWQQRCRDESDRLGDGPLDIEALEKLESLDLVMNESI
RLVTPVQWAMRQTVRDTELLGYYLPKGTNVIAYPGMNHRLPEFWTDPMTFDPDRFAEPRN
EHKRHRYAFTPFGGGAHKCLGMVFGQLEIKTILHRLLRRYRLELARPDYRACWDYGGMPV
PKDGMPIVLRPL

CYP136A1 Mycobacterium smegmatis

MPTTISTPRYLLDQARRRFTPTPNTIPGMGAIEKRLKRKQWDQFVFSTPP
AGSGLKPIMGDSGLPVLGHMIEIFRGGPDFILEQYRRNGPIHYAYSPALS
SVMALGPDATQTVFSNRNKDYSQRAWDPVIGPFFEGGLMLLDFDEHMYHR
RIMQDAFTRSRLTGYIPHIDSVASQVLANDWVSDDPRFLFYPAIKELTLD
IASEVFMGVPAGTDKKLVTTVNHAFTTTTRAGNAIVRTPVPPLKWWRGIQ
ARKTLEDYFLSRIDEKRRAESTDMFSVLCHSADEDGQTFTDDQIVSHMIF
LMMAAHDTSTSTMTTMAYHLAANPEWQDRLRDESERIGDGPLDIEALEKL
ETYDLVINEALRMMTPLPFNFRQAVRDTELLGYFIPAGTNVVTWPSINHR
LPELWTDPEKFDPERFAEPRSEHKKHRYAFAPFGGGAHKCIGMVFGQLEI
KTVMHRLLRQYRLELPRPGYTPRYDYGGMPVPIDGMPIVLRPLR

CYP136A1 Mycobacterium vanbaalenii PYR-1

MPSISTTDYVLDQAKRRLKPTPVTIPGMGAVEKRLKDKHWDQFVLAEPPAGSDLKPILGDAGLPIIGHMI
EIFRGGPDFILEIYRKHGPVYFAESPALSSVMALGPDATQAVFSNRNKDFSQRAWDPVIGPFFEGGLMLL
DFDEHMFHRRIMQEAFTRSRLTGYVSHIDSVASAVLANDWVANDPRFLFHPAIKELTLDIASEVFMGVPA
GTDRALVTTVNQAFTTTTRAGNAIVRKPVPPLTWWRGIKARKTLEDYFSSRIGEKRRSESTDMFSVLCHS
ADEDGQSFTDDQIVSHMIFLMMAAHDTSTSTMTTMAYHLAANPEWQDRLREESARIGDGPLDIEALEKLE
TYDLVINEALRMMTPLPFNFRQAIRDTDLLGYYIPAGTNVVTWPSINHRLPELWTDPEKFDPERFAEPRS
EHKKHRYAFAPFGGGAHKCIGMVFGQLEIKTVVHRLLQNYRLELPRPDYQPRYDYGGMPVPLDGMPIVLR
PLH

CYP136B1 Mycobacterium smegmatis

MTIPAAEAAADAKVRLQTAVAGITARYPSREHALAAPPPGSGLKPV
MGNYGFPILGHVMSTLVEPLAFARERYERYGPVSWAGGVGFRVALLMGPE
ALETVWINKDKAFSSTLGWAPVIGPFFHRGIMLLDFEEHRDHRRIMQQAF
TRSALNGYLDLMRPGIDRTVRSWPAAQRFPFYTSVKHLLLDQAAEVFIGA
ELGPEADQLSRDFHDTVCGGQAVIRADVPGGVWSRGLRARRRLERYFAGQ
LPARRSGEGTDLFSMLCRSRSDEGERFSDTDIVNHMIFLLMAAHDTSAIA
ISMLVYELGRNLRWQNTLRDEALSGPQGEITMEDLDSAYPLLDAAFKESL
RMYAPAGTLFRQTLTATAVAGHFIPRKTQVAIGVYASMRLADWWPEPDEF
DPARFLTGSDATAVQRYAFAPFGGGAHKCIGQQFANMNVKAIMLHLLRHF
RWHVPAGYQPRMTWGTGPTPADGLPITLERLSA

CYP136B2 Mycobacterium flavescens PYR-GCK

MSALPQSLPG LPAASAKLRF QSAAASVTSR YPSRVRPLSR PPAGSGLKPV LGNYGFPVLG
HHLSTFVEPL EFARERYERF GPVSWAGGIG FRVVQLMGPE ALETAWINRD KAFSSTRGWA
PVIGPFFHRG IMLLDFEEHR DHRRIMQQAF TRSALDGYLT LMRPGISRTV TSWPTAAGFP
FYTAIKKLLL DQAAEVFVGA VLGAEADRLS SDFHDTVCGG QAMIRADVPG GTWARGLRAR
ERLERYFAAQ IPDRRAGTGA DLFSMMCRSR SEDGDSFSDA DIVNHMIFLL MAAHDTSAIA
ISMLVYELGR NLRWQDALRD EADAGDGLGL ADLDGAYPLL DAAFKEILRM YAPAGTLFRQ
TVTDTEVCGH YIPRRTQVAI NVYASLRLAD WWPDPDRFDP GRFLGGGDAA AVHRYAFAPF
GGGVHKCIGQ QFADMNVKLV MHQLLRQFRW RVAPGYRPLM TWGTGPTPAD GLPISLQRLSGG

CYP136B3 Mycobacterium sp. KMS

MTALTAQLTS PANTHRLQVA GAALTSRFPS REEPLATPPP GSNLKPVMGN YGFPFLGHTL
SALAEPLDFA RRRYDMYGPV SWAGGVGFRV VALMGPDALE TAWINRDKVF SSTRGWAPVI
GPFFHRGIML LDFEEHRDHR RIMQQAFART ALDGYLELMR PGIDRTLGGW PASDAFPFYP
SIKHLLLEQA AEVFVGTHLG PESDQLSADF HDTVRGGQAL LRADVPGGVW ARGLRARKRL
ERYFGDQIAD RQRGDGADLF SMLCRSEDDD GARFTPADIV NHMIFLLMAA HDTTAIALSM
LVYELGRNQK WQKTLRDEAV GRPNDAPAVG DLDAYPLLDA AFKEILRMYA PAGTLFRQTT
RDTDILGHFV PAKTQVAINV HASMRLADWW PDPDTFDPAR FIDQPGARAA VSRYAFAPFG
GGAHKCIGQQ FADMTVKTTM HQMLRRFEWS VADGYRIPLT WGTGPTPADD LPITLRTLTT

CYP136B4 Nocardia farcinica IFM 10152

MVEITRSVAK GFGMSLQLPT TVSAVSDNAR HLRTRLSWQA QRAGLQVVKR YPTRIRPLAE
PPPGSGLKPV LGDFGPPGIG YTLHTLADPM GFSRERFERL GPVSWLGVLG RPVVSVAGPE
AFEEVLLDRD KVYSAQRGWE WLIGPFFHGG VMLRDFDDHM FHRRILQQAF TRPRLHGYQD
LTSPLLRRGI ESWRPAAEFH IHTAIKQLLL QQATEVFAGA ELGRESVALA HAFEDAVHGG
TAMVRANVPG GVWARGLRGR RRLEDYFRRE LPAKRAGEGN DLFSVLSRAT TEEGHTFTDE
EVVQHMIFVM LAAHDTSTIA SSMLVYELGR HPEWQDKLRA EAIGLGKESV GYDDLDELPL
LDMAFKEALR MYAPVAQQAR ETIADTALCG HYLPRGTLVM CGPYMMMRTA RYWRDPDEFD
PERFAPERRE DKSHRFAWAP FGGGAHKCIG LYFGGMTVKA VLYQMLTRFR WSVRPGYEPL
LVAGTGPTPA DGLPIRLERL AR

CYP136C1 Rhodococcus sp. RHA1 Rha02367

MPKVLAAPPPQSTLQPISGNAGFPVIGHSLDYFRDPMGLLQSRWDRYGPVSWLSMAGKRWVTVLGPDGCQTVLQNKDRAFVNSDGWSVLIGPFFHRGLMLLDGDEHLAHRRIMQQAFTRDRLSRYTEALHPAVEKGLDGWQPTAGFAAYPALKELTLDLATSIFMGGAEGSTPRE
MAEINRAFIDCVQAATSVIRYPLLGTRWKRGIDGRARLEEFFRRYLPARRAGAGEDLFSALCHIESEEGQRFSDDDVVNHMIFLLMAAHDTSTITLSTMMQYLGQHPDWQERCRRQSAALGTSTPTYDQLDELTDLDLVMKECLRLVPPVPVVARRAVEDTEVLGHYIPRGTYMSVV
VHFTHHMPEYWPDPERFDPERFAPERREDKVHRFAWEPFGGGVHKCLGMHFAGAEIKTVMHHLLRRFHWHVSPGYVAPLNYTSLPFPSDGQPVDLYHRVGGADTP

CYP136C2 Rhodococcus sp. RHA1 Rha06567

MRRELRFVMSKILAVPPAQSQLQPVSGRSGLPGVGHVLEYIRDPLALMQKHWDRYGEVSWFSMVGRRWVAVLGPDACQEVLQNKDRAFVNGDGWSVLIGPFFHGGLMLLDSEEHLRHRRIMQQAFTRSRLENTVDVLNPAIDSALDAWTPTNGFRAYTALKALTLDLATDIFMG
GAEGSTESEISSVKKAFVDCVQAATSVVRYPVPGTRWKRGLDGRRVLEDFFRQYLPARRSHETDDLFSVLCHIESEAGQRFSDDEVVDHMIFLLMAAHDTSTITISTMMQYLGQHPQWQDRCRAESLALGTPAPSYADLDGLDSLDLVMKECLRIVSPVPVMARRAVRDTQVQGHF
VPAGTYAAVVPHFTHHMPQYWPEPERFDPERFAEHRREDKVHRYAWEPFGGGVHKCLGMHFAGAEIKAIMHHLLLRFDWHVDADYVAPLNFTSLPFPSDGQPVDLRLLATS

CYP136C3 Frankia sp. CcI3

MAVRGSRGPVPGDGGPPLVGYTLRYLHDPAQHWRQRYDRYGPVSWERTFGLRVVSLLGPDATGLALRNHE
QAFANGPGQQRIAGPFFRRGLSMLDFDEHRHHRRILAGAFAPDRLRGYLAGMNPSIERGVAGWRPGARFQ
VYPAVKQLTLELATRIFMGERLGPEADRFNAALFACIRAPGAVVRVPAPGLRWSRGLAGRRYLEEFLRLR
VPAKRAGSGTDMFSRLCHAEAEDGSRLSDDDVVNHMILMMVAAHDTSTITMTSMSYYLARHPEWQQRCRE
ESLALGTPAVDHADLDRLPSLALVMKEALRLVTPVPILLRATVKDIDVLGVTVPAGTVAALALAFTHQMP
EYWPSPERFDPERFADHRREDKVHPYAWQPFGGGPHTCIGLHFAGQQVKAILHQMLLRYRWSLAPGYRIS
LDRFPLPVPRDGLPVQLEKIT

CYP136D1 Mycobacterium abscessus

1 MDAVEAAQRP GGTMTNHLLA PAHHVKERLS SVIMVPAPHA VDDRWRRWSR DWPVRELAPA
61 PAGSGLKAVR GDAGLPFVGH TLDYIRFGSD FSRERYDRLG SVSWMGAFGT KMVVIAGPDA
121 TREAFTSEAK AFSQDGWSFL IDAFFHRGLM LMSFDEHLMH RRIMQEAFTR PRLTGYVEQV
181 TPCVRSAVPA WPVGPSVRIY PLLKELTLDI ATDVFMGGRG KDESDAVNKA FVATVRAASS
241 LVRAPLPGTR FRAGVQGRRV LEDYFFRHLP AARAGETEDL FAALCQATTE DGERFSDEDV
301 VNHMIFLMMA AHDTSTITTT AVTYFLAKYP QWQEAAAAEA AAIGDGLPDI EALEKMTVID
361 RVIKEALRLL APVPLVMRKT VRDVAIDGYH IPSNTLCAIT PAVNHFDRTI WNDPERFDPS
421 RFDEPRREDQ HHRFAWVPFG GGAHKCIGMQ FGTLEVKAIL HRMLRSFTWK VPENYHVRWD
481 NTSLPIPVDG LPLEMKRR

CYP136D2 Mycobacterium marinum MM3135 OR 3315 (TYPO)

MANQLLAITR HPKERLTSVL LAPAPRVVDD KWRQWSRDWR VRELAPAPAG SGLRAVLGDA
GLPLLGHTVD YIRFGSEFSR ERYERLGSVS WMGAFGTKMV VIAGPDATRE AFTSEAKAFS
QDGWSFLIDA FFHRGLMLMS FDEHLMHRRI MQEAFTRPRL TGYVGQVAPC VRAAVPAWPT
GPSVRIYPLL KNLTLDIATD VFMGGRGKDE SAAVNEAFVS TVRAASSFVR VPLPGTRFRA
GVHGRRVLED YFSRHLPAAR AGETDDLFAA LCQATTEDGE RFSDEDVINH MIFLMMAAHD
TSTITTTAVT YFLAKHPEWQ EKAAAEARSF GHDSPDIDEL ERMTVLDLIL KEALRLLAPV
PLVMRKTVRD VAIDGYHIPR ETLCAITPAV NHFDRRIWSD PDRFDPSRFD EPRREDQQHR
FAWVPFGGGA HKCIGMQFGT LEVKAILHQM LRTYTWTVPN DYHVRWDNTS LPIPVDGLPV
TLRHR*

CYP137A1 Mycobacterium tuberculosis

MVLRSLASPAALTDPKRCASVVGVAAFAVRREHAPDALGGPPGL
PAPRGFRAAFAAAYAVAYLAGGERRMLRLIRRYGPIMTMPILSLGDVAIVSDSALAKE
VFTAPTDVLLGGEGVGPAAAIYGSGSMFVQEEPEHLRRRKLLTPPLHGAALDRYVPII
ENSTRAAMHTWPVDRPFAMLTVARSLMLDVIVKVIFGVDDPEEVRRLGRPFERLLNLG
VSEQLTVRYALRRLGALRVWPARARANTEIDDVVMALIAQRRADPRLGERHDVLSLLV
SARGESGEQLSDSEIRDDLITLVLAGHETTATTLAWAFDLLLHHPDALRRVRAEAVGG
GEAFTTAVINETLRVRPPAPLTARVAAQPLTIGGYRVEAGTRIVVHIIAINRSAEVYE
HPHEFRPERFLGTRPQTYAWVPFGGGVKRCLGANFSMRELITVLHVLLREGEFTAVDD
EPERIVRRSIMLVPRRGTRVRFRPAR

CYP137A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(4064642..4066072)
Gene = CYP137 1 aa diff
locus_tag = Mb3710c

CYP137A2 Mycobacterium marinum MM5175

MPASAPSART PPALRRPPGL PAPRRLRTVF AAAYAVAYLV GGERRMLRLI RRYGPIMTMP
ILSLGDVAIV SDPALVKEVF TAPPDVLLGG EGVGPAAAIY GAGSMFVQEE PEHLRRRKLL
TPPLHGTALG RYVPIIEEST RAAMRDWPVD RPFELLGAAR ALMLDVIVKV IFGVDDPDEV
RRLGRPFERL LDLGVSEQLT VRYALRRAGA LRVWPQRARA YREIEDVVMP LIAQRRSDLG
RTEQRDILGL LISARGDDGE QLSDQEIRDD LITLMLAGHE TTATTLAWVF DLLLHHPDAL
RRVQEEAEGG TETFTTAVIN ETLRVRPPAP FTARVAARPF RLGGYLIDPG TRIVVHMIAI
NRNPDVYEQP NRFRPERFLG TRPQTYAWVP FGGGAKRCLG AAFSMRELVT VLHVLLREGQ
FTAVDEAPER IVRRSIMLAP RHGTRVRFRP RLQESV*

CYP137A2P Mycobacterium ulcerans

VPASAPSARTPPALRRPPGLPAPRRLRTVFAAAYAVAYGWWRAANAAIDPALRADHDDAH
PEPGRRGDRLGPGTGQRSLHRAARRAPGW*MLRLIRRYGPIMTMPILSLGDVAIVSDPAL
VKEVFTAPPDVLLGGEGVGPAAAIYGAGSMFVQEEPEHLRRRKLLTPPLHGTALGRYVPI
IEESTRAAMRDWPVDRPFELLGAARALMLDVIVKVIFGVDDPDEVRRLGRPFERLLDLGV
SEQLTVRYALRRAGALRVWPQRARAYREIEDVVMPLIAQRRSDLGRTEQRDILGLLISAR
GDDGEQLSDQEIRDDLITLMLAGHETTATTLAWVFDLLLHHPDALRRVQEEAEGGTETFT
TAVINETLRVRPPAPFTARVAARPFRLGGYLIDPGTRIVVHMIAINRNPDVYEQPNRFRP
ERFLGTRPQTYAWVPFGGGAKRCLGAAFSMRELVTVLHVLLREGQFTAVDEAPERIVRRS
IMLAPRHGTRVRFRPRLQESF

CYP137A3 Mycobacterium vanbaalenii PYR-1

MAEHSPHESYRCEMVHIVRPPSLPAPPPLAPVFGGLYAAAFGMGGQAIVAQMVRRYGPVVALPVLGFGKV
VAVADAALAKQVFTENPDVLLGGEGVGPAAAIYGPRSMFVLEEPGHLRRRRLLTPPLHGELLGSYVPIIE
SSTRSAMATWPVGRPMRMLDAARELTLDVIVQVVFGVHDPESVARFGKPFHELLDLALSEETPVRYALRR
FGALRRWGRLSDANRRIDELVLPLIAERRSDPLSAERADILSMLANSHTDDGETLSDNEIRDDLITLVLA
GHETTATTLSWLIDLLLHHPRALARVRAEAVSGDTGYTEAVIAETLRLRPAAPITGRMTTGPYRLGDYTL
EPDTRIVLLLDVINRNPDTYPQPDEFRPERFLGSRPHPYAWIPFGGGVKRCIGAAFAMRELTTTLHTVLR
EGELEPVSARPETPPLRAAPVLVPRDGTRVRFTPARPAASPRCADRTSTV

CYP138A1 Mycobacterium tuberculosis

MSEVVTAAPAPPVVRLPPAVRGPKLFQGLAFVVSRRRLLGRFVR
RYGKAFTANILMYGRVVVVADPQLARQVFTSSPEELGNIQPNLSRMFGSGSVFALDGD
DHRRRRRLLAPPFHGKSMKNYETIIEEETLRETANWPQGQAFATLPSMMHITLNAILR
AIFGAGGSELDELRRLIPPWVTLGSRLAALPKPKRDYGRLSPWGRLAEWRRQYDTVID
KLIEAERADPNFADRTDVLALMLRSTYDDGSIMSRKDIGDELLTLLAAGHETTAATLG
WAFERLSRHPDVLAALVEEVDNGGHELRQAAILEVQRARTVIDFAARRVNPPVYQLGE
WVIPRGYSIIINIAQIHGDPDVFPQPDRFDPQRYIGSKPSPFAWIPFGGGTRRCVGAA
FANMEMDVVLRTVLRHFTLETTTAAGERSHGRGVAFTPKDGGRVVMRRR

CYP138A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome 163556..164881
Gene = CYP138 100% match
locus_tag = Mb0141

CYP138A2 Mycobacterium smegmatis

66% to CYP138A1
MTATVERPESAIRAAQLPPVLPLPKTVQGLAFSVARRWVVKQAARRYGDV
VTLDIPVFGRTVLVTEPQLAKQVYAAHPDDVGNVQPNLSRMLGPGSVFAL
DGTDHRRRRKLLTPPFHGRSIKNYERIFEEETLREAASWPDGQEFRTLEP
MMRITLNVILRAVFGADGEQLDELRRIIPPWVTLGSRLAVLPTPKRNYGR
LTPWGRLAAYRAEYDDVVDRLIDRVEADPDFDQRDDILALLLRSAYEDGS
SMSRKDIGDELLTLLAAGHETTASTLGWAFERISRHPGVLEKLVAEAATD
DNEYRQAAIAEVQRVRTVIDFSGRHVYAPSFQLGQWTIPRGYSIMVAIAH
IQEREEEFSDPHRFDPQRFVGNRPGLGWLPYGGGTRRCVGAVFANIEMDV
VLRTILRHFVIETTTAPDEKVHPRGVAYTPASGGRVVMRRRREPLGA

CYP138A3 Mycobacterium marinum MM0346

MNQAISDAPA VPAVKMAQAT RIPKLLQGLA FATSRRRMMD WLSRRNGDVF ALNVPIYGHM
VVVNDPQLAK QVFTASPEDL GNIQPNLSRM FGSGSVFGLD GDDHRRRRRL LAPPFHGKSM
KNYEIIIEQE TLRETANWPE GQLFPTLPSM MRITLNAILR AVFGADGAEL DELRRIIPPW
TTLGSRLASM PKPKRRYGRF SPWGRLAEYR RQYDVIIDRL IDQERSDPNF SDRTDVLALM
LRSTYDDGSR MSRKDIGDEL LALLAAGHET TASTLSWAFE RVTRHPELLA ALVAEAEDAG
GELRQATILE VQRARTVIDF AARHVYAPQY QLGQWMIPRG QSILVNIAQM HANPDIFPDP
QRFDPQRFIG GRPSTFGWIP FGGGTRRCVG AAFANMEMDV VLRTVLRNFT IEPTTAAGER
LFCRGVAYTP KNGGRIVVHR R*

CYP138A3P Mycobacterium ulcerans

MNQAISDAPAVPAVKMAQATRIPKLLQGLAFATSRRRMMDWLSRRNGDVFALNVPIYGYM
VVVNDPQLAKQVFTASPEDLGNIQPNLSRMFGSGSVFGLDGDDHRRRRGLLVPPFHGKSM
KNYEIIIEQETLRETANWPEGQLFPTLPSMMRTTLNAILRAVFGADGAELDELRRIIPPW
TTLGSRLASMPKPKRRYGRFSPWGRLAEYRRQYDVIIDRLIDQERSDPNFSIGPTCWP*V
LALMLRSTYDDGSRMSRKDIGDELLALLAAGHETTASTLSWAFERVTRHPDLLAALVAEA
EDAGGELRQATILEVQRARTVIDFAARHVYAPQYQLGQWMIPRGQSILVNIAQMHANPDI
FPDPQRFDPQRFIGGRPSTFGWIPFGGGTRRCVGAAFANMEMDVVLRTVLRNFTIEPTTA
AGERLFCRGVAYTPKNGGRIVVHRR

CYP138A4 Mycobacterium marinum MM3976

MTELVAAAAV PPAVRLPPEF RMPKALQAIT YVALRRWLLL RLARRYGKVF SVNLPLYGHI
VVVGDCLLAK QVLATSPEEL GNIEPNLGRL FGPGSIFSLD GEEHRQRRRL LMPLFHGNLM
KSYESIIEDE TLREVANWPE GQSFPAMPAM AQITLGGILR ALFGPECAEL DELRRLVPPW
VTLGLRIALL PRPRRDYGRY SPWARLAEMR HQCEIVIEKL IEAARTGPNL AERTDVLALM
LRSCYDDGSA MSHNDIVDEL LTMMAAGHET TAATLTWAFE RLGRHPDVLA ALVEEADRGG
RALRQATILE VQRTRPAIDR VVRRVCSPYY RLGQWVLPQG YSVHLHIEQV QSDPEIFPDP
ERFDPHRHMG GKPSSLGWIP FGGGTRRCIG AALANLEIDV VLRTVLRNFT IEPNAAPDER
WHNRGIAFTP KDGGQIVVHR RH*

CYP138A4P Mycobacterium ulcerans

MTELVAAAAVPPAVRLPPEFRMPKALQAITYVALRRWLLLRLARRYGKVFSVNLPLYGHI
VVVGDSLLAKQVLATSPEELGNMEPNLGRLFGPGSIFSLDGEEHRQRRRLLMPLFHGNLM
KSYESIIEDETLREVANWPEGQSFPAMPAMAQITLGGILRALFGPECAELDELRRLVPPW
VTLGLRIALLPRPRRDYGRYSPWAGLAEMRHQCEIVIKKLIEAARTGPNLAERTDVLALM
LRSCYDDGSAMSHNDIVDEPLTMMAAGHETTAATLTWAFERLGRHPDVLAALVEGGRPGR
SRPPAGDDPGSPADQAGDRSSSSTRLLALLPARSMSSAPRVFGPPSYRTSSIRSRGLSRP
GALRSASPHGGASHRRSDGSHSVAGLAAASGLP+VVLRTVLQHFTIQPNAAPDERWHNRG
IAFTPKDGGQIVVHRRH

CYP138A5 Mycobacterium vanbaalenii PYR-1

MSEATIAAHRSTADAESAPPRPVRLPPTPRIPKLLQGLGFSFSRQWTVAQIVRRYGDVFSMTLPVFGPTV
MVADPALAKQLFMANTDDVGNIQPNLSRVLGSGSVFALDGGDHRKRRKLLTPPFHGKSIKNYETIFEEET
LREAANWPEGQPFETLEPMMRITLNAILRAVFGADGAHLDELRRIIPPWVTLGSRLAVLPTPHRTYGRFS
PWGRLAAYRRQYDDVIGRLIDAVQADPDFDTRDDILALLLRSTYEDGSTMSRQDIGDELLTLLAAGHETT
AATLGWAFERISRHPEVLAKLVAEAETDGNEYRQATILEIQRSRTVIDFAGRHVYAPTFELGEWVIPQGY
SIVVAIGQVHKRAQDFDDPDRFDPQRYIGQRPPTFAHIPFGGGTRRCVGAAFANVEMDIVLRTVLRHFVI
ETTAAPGEKMHSRGVAYTPKDGGRVVMRRR

CYP138A6P Mycobacterium leprae

1 NRVAREIVVEVIYGALFGAFEALSGLVPQDTVLGPMGRYSMAPSLIR
439 ITINVIMRAGFGSELDELRRLHPTAATL 522
RWTVERQARCNHDIFMLDSRSTAERLRRRLHGTCMKNH 351
352 VRIFEAEPLWGLRTGLKASLLPHCRLINRITINVIMRAGFGSELDELRRLHPTAA 516
517 TLVGLF*LLSQHLGVLADPSSMGATMPGDDPAPALRQATIPG
638 LGVQWTRTVIDFAARRVYSSVYHLSEWAIPREDSILISIAQIYXXXXXXXXXXXX 766
795 DPRRYVEHKPSSFAWI 842
PFSGGT 861
862 SRCVSICQDGDGMNVVLKMVLRYWIIDTTTAPGER*HLRGVVYTPRNGGR 1011

CYP138B1 Mycobacterium marinum MM4430

MAEATTDPIQ LPPGPNASKL TQTLVYVFAK ARARTRLTNR YGSGYSLNLP KYGPTLVISD
PAMLKELFTS GNDLVTRPTT LGKLLGPGSI LSMIGVEHRQ RRKLMVPPFS GRRIDAYVKI
VEEEFLREAQ TWPEETEFES LQALVNITGS IVLRTILGAH GAIFEELQYL GPRTIVLAAR
MIALPEWLRR DLGPWSPWGK IQAARSRFDE LIAQLIAEAR ADPNFETRTD MLAMMLQARY
DDGSPITDAH ISDEMLTMIV AGHETTATTL AWAVERLRRS PSFVAQLVDE IDNGGTALMQ
ATVWEVQRTR PVLDFIARRV ETQLRLGPWV LPKGHMIVGD VWAAQHASSS FKDPERFDPT
RFADGPPESY AWIPFGGGIH RCIGAAFANM EMTTVLRTLL RKFELVPTDA PAEPIRSRGI
TNAPGHGGRI VVRSRPAGAR AAYASEDGHS AVAQSV*

CYP138C1 Mycobacterium vanbaalenii PYR-1

MATATTDPVRLPPGPRIPKLIQGAAVLTQRYGAIAALGRRYGPTFTLNIPVFGETVVISDPVLVKDLFST
HRDLVGRPQNNLGGDVLGPGSIFNLEGDALQARRKLLLPPFNGKSMRGYASITEEEAIREIRTWPEGVEF
ETLEPMMRITLNTILRAVFGAEGEQLDELRELMPKAVEFGSKIALMPSIVRKDFGPWSPGGKFARYRKRM
DELLNGLLNDARSDPNFTERNDVLSLLLQARYDDGSPMPDSFILDELLTMLVAGHETTSTQLAWTIERIR
RHPQLLVRLTEEVDAGGNELLLATIAESQRTRPVLTAALRRARTRIRLGEWVIPEGDTILASTQLAMAAE
SSFPDADKFNPDRFVGNPPNPFAWIPFGGGMMRCIGASFATMEMEVTLRALLREFTIEPTTEPDEKPHSR
GVTVTPGRNGRLVVHRREHKAARATDSVSVAESS

CYP138C2 Mycobacterium flavescens PYR-GCK

MATATTDPVR LPPGPRFPKL IQGGAVLAFR YGSVAALGRR YGSTFTLQLP VFGETVVISD
PVLVKDLFST SRELVGRPQN NLGGDVLGPG SIFNLEGDEL LARRKLLLPP FNGKNMRAYE
DITEQEVIRE MQSWPEGVEF ETLEPMMRIT LNTILRAVFG AKGDELDELR VVIPAAVEFG
SKIALLPSVV RKDLGAWSPG GKFARYRRRM DEICTQLIAD ARSDPDFTDR GDVLSLLLQA
RYDNGDPIPD AFVVDELLTM LVAGHETTST QLAWTIERIR RHPDLLARLS DEVDAGGNEL
MAATIAESQR TRPVLTAALR RARTRIRLGE WVIPEGDTIM ASTQLAMAAE QSFPDAEKFN
PDRFVGNPPN PFAWIPFGGG MMRCIGASFA TMEMDVTLRT MLREFRLEPT DEPDEKPHSR
GVTVTPGRGG RAVVRRRRTP ASGDANSVSV AETSR

CYP139A1 Mycobacterium tuberculosis

mrtyrtvRYPLGEALLALYRWRGPLINAGVGGHGYTYLLGAEANRFVFAN
ADAFSWSQTFESLVPVDGPTALIVSDGADHRRRRSVVAPGLRHHHVQRYVATMVSNID
TVIDGWQPGQRLDIYQELRSAVRRSTAESLFGQRLAVHSDFLGEQLQPLLDLTRRPPQ
VMRLQQRVNSPGWRRAMAARKRIDDLIDAQIADARTAPRPDDHMLTTLISGCSEEGTT
LSDNEIRDSIVSLITAGYETTSGALAWAIYALLTVPGTWESAASEVARVLGGRVPAAD
DLSALTYLNGVVHETLRLYSPGVISARRVLRDLWFDGHRIRAGRLLIFSAYVTHRLPE
IWPEPTEFRPLRWDPNAADYRKPAPHEFIPFSGGLHRCIGAVMATTEMTVILARLVAR
AMLQLPAQRTHRIRAANFAALRPWPGLTVEIRKSAPAQ”

CYP139A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(1877656..1878948)
Gene = CYP139 start codon differs by 6 aa
locus_tag = Mb1694c

CYP139A2P Mycobacterium leprae

GAAVATTSMTVILARLASRTRLHLLAHYTHRVRARNFAALIP*LSLTVEVINSMPTQ

CYP139A3 Mycobacterium marinum MM2475

MSTYRTVPYR PGEALLALYR RRGAFIDAGV GRHGFVYLLG PEANRFVFAN ADAFSWRETF
ESLVPVDGPT ALIVSDGEDH RRRRSIVAPG LRHRSVQDYV ATMVSTIDNV IDSWRPGQPL
DIYQEFRCAV RRSTTESLFG PRLASHSDYL GRQLQPLIDL THRLPQVMQL QQRLNSPGWR
RAMAARTRID ELIDAEIANA RAEPSPDDRM LTALINGRSE EGCALSDNEI RDSIVSLIAA
GYETTSGALA WATYSLLTLP GAWETAAREV ARVLGGTAPS AETLGALTYL NGVVHETLRL
YSPGVVSARR LIRDLWFDGH RINSGRLLIF SAYVTHRIPE VWPNPTQFLP QRWDPAAPDY
RKPAPHEFIP FSGGLHRCIG AVMATTELVV LLARLVARTR LRLPAQRIRA ANFAALAPKP
GLRVEFVDSV PAQ*

CYP139A3P Mycobacterium ulcerans

VPYRPGEALLALYRRRGAFIDAGVGRHGFVYLLGPEANRFVFANADAFSWRETFESLVPV
DGPTALIVSDGEDHRRLCSTVAPGLRHRSVQDYVATMVSTIDNVIDSWRPGQPLDIYQEF
RCAVRRSTTESLFGPRLASHLDYLGRQLQPLIDLTHRLPQVMQLQQRLNSPGWRRAMAAR
TRIDELIDAEIANARAEPSPDDRMLTALINGRSEEGCALSDTRFATPSFRSSRPATRPPA
QRWRGPPTPCSRCPAPGRRRPARLPGCSAAPRPAPRPSALSPTSMALCTKRFGSTHREWS
RRAG*LRGAPQHDREPVRPTAGLPFGLSGPTTAASDRPDPPVAPGDATTAAAQLTGLAAG
DGRAHPHRRTDRCRNRQRSRGAQPRRPHADRTDQRPFRRRLRVERHEIRDSIVSLIAAGY
ETTSAALAWATYTLLTLPGAWETAAREVARVLGGTAPSAETLGALTYLNGVVHETLRLYS
PGVVSARRLIRDLWFDGHRINSGRLLIFSAYVTHRIPEVWPNPTQFLPQRWDPAAPDYRK
PAPHEFIPFSGGLHRCIGAVMATTELVLLARLVARTRLRLPAQRIRAANFAALAPKPGLR
VEFVDSVPAQ

CYP140A1 Mycobacterium tuberculosis

MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPF
YDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQ
LHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIV
DVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRG
FDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV
NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR
IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGE
VGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP

CYP140A1 Mycobacterium bovis subsp. bovis AF2122/97,

MKDKLHWLAMHGVIRGIAAIGIRRGDLQARLIADPAVATDPVPF
YDEVRSHGALVRNRANYLTVDHRLAHDLLRSDDFRVVSFGENLPPPLRWLERRTRGDQ
LHPLREPSLLAVEPPDHTRYRKTVSAVFTSRAVSALRDLVEQTAINLLDRFAEQPGIV
DVVGRYCSQLPIVVISEILGVPEHDRPRVLEFGELAAPSLDIGIPWRQYLRVQQGIRG
FDCWLEGHLQQLRHAPGDDLMSQLIQIAESGDNETQLDETELRAIAGLVLVAGFETTV
NLLGNGIRMLLDTPEHLATLRQHPELWPNTVEEILRLDSPVQLTARVACRDVEVAGVR
IKRGEVVVIYLAAANRDPAVFPDPHRFDIERPNAGRHLAFSTGRHFCLGAALARAEGE
VGLRTFFDRFPDVRAAGAGSRRDTRVLRGWSTLPVTLGPARSMVSP

CYP140A2 Mycobacterium smegmatis

MRERLRWMALHGFVRSMATLGLRRGDPQARLIADPVVRADPTTFADQMRKQGPVIRG
RVVLLTFDHAVAFDLLRSDDFQVSQLGANLPKPLRWIADKTNPGLLHPIE
PPSLLSIEPPDHTRMRKLVSSVFTTRAVATLRERVEQTAHELLDGLEAES
GVVDIVERYCAQLPVAVIGDILGVPEPDRPNILRYGELGAPSLDIGLSWS
QYQQVNEGIIGFETWLNRHLRTLRRDPGDDLLSQIITASESGATGEPLTD
RELKALAGLVLAAGFETTVNLLGNGIRMLLDHREHLETLAARPDVWPNAV
EEILRLDSPVQMTARAAVRDVDVAGTAVGRGELVVLHIAGANRDPKVFDD
PHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRAFFDRFPDARL
AGDPVRRDTRVLRGWSTLPIALGKARAAVGS

CYP140A3P Mycobacterium leprae TN

VRQRLHWFAQYGFIRGIAATHH
RRSDPLARLDIALAIKANPVP
YCHKPRPRRPLVQSRISYLTANRAITHELLQSEDFHVFWLNVTLPAPSHWL
RRRTGYRTSSQYNL
LHPLLAIQ*AYHIHYRKTVSPLFAPKAVATLRDRIEQTTLALLDQLAHQHDVVDVVNRY
CSQLPVAVISDILGYP
VPDRDRSHILKFGELVAPSLDVELT*Q*YQQA*REVAGFNFWL
LKHLPQLQRTPGDNLVRHLSH*EDNKPTEISLSKSKLQAISG
GLVLATGGETTVNLLGRGI
LLLDTPEHMVMLQACPEPGHKRG*EILRLDSPIQMAARVARKDVDLAGSTIKRSQVVVLY
FGRSQPGPVRLCRSR*VQHRTPQCGKESRIFR*QEFCLENALTRAYNAVGLRAFFDHLP*
TRAAGTRSRLDTRVLRGWSTLPIALGPTRSMVS

CYP140A4 Mycobacterium avium subsp. paratuberculosis

GAAARQSRPVGPRRSRRSCDRQPGPDDRAHAPPATSTSAPAMVG
LVPRRARNRDPKVFSDPTTFDVTRPNAREHLAFASGIHACLGAALARIEGATCARSFE
NFPDRSSRARNGGR

CYP140A5 Mycobacterium marinum MM2768

MKDKLHWFAM HGVIRGMANI GLRRGELEAR LIADPAVAAN PGPFHDELRR HGRMVRTRVN
YLTVDYQLAH DVLRSDDFHT ISFGENLPGP LRWLERRTRD EQLHPLRPPS LLAVEPPDHT
RYRKTVSAVF TSRAVAALRD RVEQTANSLL DQLAQRPGVV DVVGQYCSQL PIMVISEILG
VPEQDRGRVL EYGELAAPSL DIGVPYRQYR RIQQGITGFN SWLTAHLEQL RRNPGDDLMS
QLIRVAESGD AGTYLDESEL RAVAGLVLVA GFETTVNLLG NGIRMLLDAP EQLETLRQRP
ELWPNAVEEI LRLDSPVQLT ARVARTDVEI ASWPINRGEM VVAYLAGANR DPAVFPNPHR
FDVERANAGR HLAFSTGRHF CLGAALARAE GEVGLRTFFE RFPDVRAAGA GSRRDTRVLR
GWSTLPVTLG PARALAAS*

CYP140A5 Mycobacterium ulcerans

VKDKLHWFAMHGVIRGMANIGLRRGELEARLIADPAVAANPGPFHDELRRHGRMVRTRVN
YLTVDYQLAHDVLRSDDFHTISFGENLPGPLRWLERRTRDEQLHPLRPPSLLAVEPPDHT
RYRKTVSAVFTSRAVAALRDRVEQTANSLLDQLAQRPGVVDVVGQYCSQLPIMVISEILG
VPEQDRGRVLEYGELAAPSLDIGVTYRQYRRIQQGITGFNSWLTAHLEQLRRNPGDDLMS
QLIRVAESGDAGTYLDKSELRAIAGLVLVAGFETTVNLLGNGIRMLLDAPEQLETLRQRP
ELWPNAVEEILRLDSPVQLTARVARTDVEIASWPINRGEMVVAYLAGANRDPAVFPNPHR
FDVERANAGRHLAFSTGRHFCLGAALARAEGEVGLRTFFERFPDVRAAGAGSRRDTRVLR
GWSTLPVTLGPARALAAS

CYP140A6 Mycobacterium vanbaalenii PYR-1

MAADLQQRIRWLALHGVIRGLSKVAVRRGQDPQARLIADPAVRADPAAFADELRGRGPVIRCRAVLMTVD
HQVVNEILRSDDFRVSSLGAGLPKPLQWINRKTHPGLLHPIEPPSLLSIEPPDHTRCRKLVSSVFTTRAV
AALRERVQQTANDLLDDLERESGVVDIVERYCSQLPVAVISDILGVPERDRRHILHFGELGAPSLDIGLS
WRQYTQVHEGLVGFNEWLGGHMDELRRNPGDDLMSQLIQASQAADEGSRLTDRELQATAGLVLAAGFETT
VNLLGNGIRMLLETPGHLETLAARPELWPNAVEEILRLDSPVQMSARFARRDVTVGGTEIKRGELVILHL
AGANRDPEVFTDPHRFDIERDNAGRHLSFSGGRHFCLGAALARAEGEVGLRTFFERYPDARLAGQGSRRD
TRVLRGWSTLPITLGTARAALGS

CYP140A7 Mycobacterium ulcerans

MVMANPAPFCDELRAIGPVVSSYGTHLV
VSHAIAHELLRSEDFEVVSLGSNLPAPMRWLERRTRDDTPHLLLPPSLLAVEPPNHTRYR
KAVSSVFTPKAVAGLRDHVEETASALLDQLTDQASAVDIIARYCSQLPVAVICDILGVPS
RDRNRVLKFGQLAGPCLDFGLTWRQHQQVRQGLQGLHFWITEHLEELRSNPGDDLMSQMI
HASENGSSETHLHATEVRMIGLVLGASFATTMDLLGNGIQVLLDAPELRDALSQRPQLWP
NAVEEILRLEPPVQLAGRMARKDTEVAGTAIKRGQLVAIYLGAVNRDPSVFADPHRFDIT
RANANRHLAFSGGRHFCLGAALARVEGEVGLRMLFERFPDVRAAGPGNRRDTRTLRGWSQ
LPVQLGAARSMAIR*

CYP140B1 Mycobacterium vanbaalenii PYR-1

MGQHAGRQAGPGGAGRPVGRSGARRSGGGQPWAARAAGRRRAQVGAGAGPGSGRAAHGRHLRRPSPRQPD
RRMRSRPAVWLRWATVHGVPRAFLTVRARRGEPLARLILGRGDRLALIEEIRAAGPLMRTPVVWATADYD
VCRTVLRDNDFGVADPSETGLPDALLGLIRRVDPGLPNPVEPPAMLMTDPPQHTEYRKLVSRSFTPRSIA
ALDTRIGELTAELLDDLGRRREVDLIADYAAQLPAAVISRMLGVPDEDRARILGWGETGAALLDIGIGWR
PFRAAIDGLVDVDTHLGAHFRRLHQNGADGTPFSSLALDGSLSGRELISNAALLVGAGVETTVNLIGNGI
AALLDHPDQLALLRDDPGLWPSAVEEILRYDSPVQMTARTAHRDTEIAGVGIRKGAVIVMLLGGANRDPK
VFDRPQTFDITRANARDHLAFASGIHVCLGAALARIEGATALRELFTRYPDLHLTAPAEPRDLVTLHGYR
HLPVRLGRAATATRRAS

CYP141A1 Mycobacterium tuberculosis

MTSTSIPTFPFDRPVPTEPSPMLSELRNSCPVAPIELPSGHTAW
LVTRFDDVKGVLSDKRFSCRAAAHPSSPPFVPFVQLCPSLLSIDGPQHTAARRLLAQG
LNPGFIARMRPVVQQIVDNALDDLAAAEPPVDFQEIVSVPIGEQLMAKLLGVEPKTVH
ELAAHVDAAMSVCEIGDEEVSRRWSALCTMVIDILHRKLAEPGDDLLSTIAQANRQQS
TMTDEQVVGMLLTVVIGGVDTPIAVITNGLASLLHHRDQYERLVEDPGRVARAVEEIV
RFNPATEIEHLRVVTEDVVIAGTALSAGSPAFTSITSANRDSDQFLDPDEFDVERNPN
EHIAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIK
ELLVTWPT

CYP141A1P Mycobacterium bovis subsp. bovis AF2122/97,

IAFGYGPHACPASAYSRMCLTTFFTSLTQRFPQLQLARPFEDLERRGKGLHSVGIKELLVTWPT*

CYP142A1 Mycobacterium tuberculosis

MTEAPDVDLADGNFYASREARAAYRWMRANQPVFRDRNGLAAAS
TYQAVIDAERQPELFSNAGGIRPDQPALPMMIDMDDPAHLLRRKLVNAGFTRKRVKDK
EASIAALCDTLIDAVCERGECDFVRDLAAPLPMAVIGDMLGVRPEQRDMFLRWSDDLV
TFLSSHVSQEDFQITMDAFAAYNDFTRATIAARRADPTDDLVSVLVSSEVDGERLSDD
ELVMETLLILIGGDETTRHTLSGGTEQLLRNRDQWDLLQRDPSLLPGAIEEMLRWTAP
VKNMCRVLTADTEFHGTALCAGEKMMLLFESANFDEAVFCEPEKFDVQRNPNSHLAFG
FGTHFCLGNQLARLELSLMTERVLRRLPDLRLVADDSVLPLRPANFVSGLESMPVVFT
PSPPLG

CYP142A1aP Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(3898119..3898736)
gene = CYP142A1a aa 1-197 100%
locus_tag = Mb3548c
In Mycobacterium bovis, a frameshift due to a single base
deletion (c-*) splits CYP142 into 2 parts (pseudogene)

CYP142A1bP Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome complement(3897541..3898122)
gene = CYP142A1b aa 207-end 100%
locus_tag = Mb3547c
In Mycobacterium bovis, a frameshift due to a single base
deletion (c-*) splits CYP142 into 2 parts (pseudogene)

CYP142A2 Mycobacterium smegmatis

MTQMLTRPDVDLVNGMFYADGGAREAYRWMRANEPVFRDRNGLAAATTYQ
AVLDAERNPELFSSTGGIRPDQPGMPYMIDMDDPQHLLRRKLVNAGFTRK
RVMDKVDSIGRLCDTLIDAVCERGECDFVRDIAAPLPMAVIGDMLGVLPT
ERDMLLKWSDDLVCGLSSHVDEAAIQKLMDTFAAYTEFTKDVITKRRAEP
TDDLFSVLVNSEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLL
RHRDQWDALVADVDLLPGAIEEMLRWTSPVKNMCRTLTADTVFHGTELRA
GEKIMLMFESANFDESVFGDPDNFRIDRNPNSHVAFGFGTHFCLGNQLAR
LELRLMTERVLRRLPDLRLADDAPVPLRPANFVSGPESMPVVFTPSAPVLA

CYP142A3 Mycobacterium marinum MM5003

MTKPLIKPDV DLTDGNFYAS RQAREAYRWM RANQPVFRDR NGLAAASTYQ AVIDAERQPE
LFSNAGGIRP DQDALPMMID MDDPAHLLRR KLVNAGFTRK RVKDKERSIA QLCDTLIDAV
CERGECDFVR DLAAPLPMAV IGDMLGVLPE QREMFLRWSD DLVTFLSSHV SQEDFQVTID
AFAAYNDFTR ATIAARRAEP TDDLVSVLVS SEVDGERLSD DELVMETLLI LIGGDETTRH
TLSGGSEQLL RNRDQWDLLQ SDRELLPGAI EEMLRWTAPV KNMCRMLTAD TEFHGTALSE
GEKIMLLFES ANFDEAVFTD PEKFDIQRNP NSHLAFGFGT HFCMGNQLAR LELSLMTARV
VQRLPDLRLA DQDSRLPLRP ANFVSGLESM PVVFTPSRPL S*

CYP142A3 Mycobacterium ulcerans

MAMTKPLIKPDVDLTDGNFYASRQAREAYRWMRANQPVFRDRNGLAAASTYQAVIDAERQ
PELFSNAGGIRPDQDALPMMIDMDDPAHLWRRKLVNAGFTRKRVKDKEHSIAQLCDTLID
AVCERGECDFVRDLAAPLPMAVIGDMLGVLPEQREMFLRWSDDLVTFLSSQVSQEDFQVT
IDAFAAYNDFTRATIAARRAEPTDDLVSVLVSSEVDGERLSDDELVMETLLILIGGDETT
RHTLSGGSEQLLRNRVQWDLLQSDRELLPGAIEEMLRWTAPVKNMCRMLTADTEFHGTAL
SKGEKIMLLFESANFDEAVFTDPEKFDIQRNPNSHLAFGFGTHFCMGNQLARLELSLMTA
RVVQRLPDLRLADQDSRLPLRPANFVSGLESMPVVFTPSRPLR

CYP142A4 Mycobacterium vanbaalenii PYR-1

MTSTLPALDVDLADGNFYADGRAAREAYKWMRANQPVFRDRNGLAAATTYQAVLDAERNPELFSSTGGIR
PDQPGMPYMIDMDDPAHLLRRKLVNSGFTRKRVMDKVPSIENLCDTLIDAVCERGECDFVRDIAAPLPMA
VIGDMLGVLPDERDMLLKWSDDLVCGLSSTVDEQTIQKLMDTFAAYTAFTTEVIADRRANPRDDLFSVLV
NAEVEGQRMSDDEIVFETLLILIGGDETTRHTLSGGTEQLLRHQDQWRQAVADPELLPGAIEEMLRWTSP
VKNMCRTLTADTEFHGTSLKAGEKIMLMFESANFDEAVFENPDEFDIHRNPNSHMAFGFGTHFCLGNQLA
RLELRLMLTKILQRLPDLRLADESMLPLRPANFVSGLESMPVVFTPTAPVGA

CYP142A5 Rhodococcus sp. RHA1 Rha05910

MRRSASMTNRPDFDLIDGRFYSGELGDPRQAYAWMRAHEPVYRADGILGAASYEAVLAAERDPELFSNAGGIRPGLGPLPQMIDMDDPQHLQHRRLVNAGFTRKQVEAKIGRIREICDHLIDAACDKDEVDFVRDLAAPLPMAVVGDMLGMRPEERDTFLQWSDDLMNALGSNAT
PEELQAQANAYLAFNEFTLRTIEERRQNPTDDLTSILVHSEIDGHRLSDPDIVGETLLILIGGDETTRHVLSGGMEQLMRHPDQHQRLVNDPDGIPAAVEEMLRWSSPIKNMCRTVTRDVEFFGTDLRQGEKMMLLFESANFDDAVFDSPEVFDIERSPNPHVAFGFGTHFCLGNQFARL
EAKIMFEQLLSRLPDMVLVDDGPLRRRPANFVSGLEEMPVKL

CYP142B1 Mycobacterium vanbaalenii PYR-1

MTTAVPTHRDIDLSDRNFWARPHEERDAAFAVLRRENPVPWSRPADSDLLPPEQNLKGFWSLTKHEDIRY
ASRHPEIFSSAEGITVEDFPVEIRMMSQSFIAMDAPRHTQLRGITLDAFKPRNMLRLQDWIQGHARDLIS
EISHLGEGDFVDLVSVKLPGRIFGSFFGLPPGELHEKTINAAQRTLGWTDPEVRGDLTAVELFVGAVMDL
HETVTTLLPERRANPGDDLLSWMVQAEFDGEKMTDDELKAFFTLLAVAANDTTRHASAHAILAFSQFPDQ
RDLLVADVEGRVDTAVEEVLRWASPLVHMRRTAVQDVTLRGSEIKAGDKVVLWYSSANRDEDIFEDPFKF
DIARNPNPHIAFGGGGPHFCLGAALARTMLRSLLTEVYTRIPDISAPEPRYQVANFINGINSLPATWTPERR

CYP142B2 Mycobacterium sp. JLS

MTTVFPETTH GDIDLSAREF WAKPPVERDA AFAVLRRENP VAWSRPADSD LLPPEQNLKG
FWSLTKHEDI RYASRHPEIF SSAQGITMED FPHEILMMSQ SFIAMDAPRH TQLRGITLDA
FKPRNMRRLQ GWVQEHARDL ISEMSHLGEG DFVELVSVKL PGRIFGSFFG LPPGEIHEKT
IDAAQRTLGW TDPDVRGDRT ALELFAGAVM DLHETVTTLL PERRANPGDD LLSWMVQAEF
DGVKMTDDEL KAFFTLLAVA ANDTTRHASA QAIYAFSQFP DQRDLLVADV EGRVDSAVEE
ALRWASPLIH MRRTATQDVT VRGAEIKAGD KVVLWYSSAN RDEDVFDDPF TFDIERNPNP
HLAFGGGGPH FCLGAALART MLRSLLTEVY TRIPDIHAPE PKFQVANFIN GINSLPATWT
PERR

CYP143A1 Mycobacterium tuberculosis

MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFM
NGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYF
SPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRL
IGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLS
EIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLE
PSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWG
FGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS

CYP143A1 Mycobacterium bovis subsp. bovis AF2122/97,

MTTPGEDHAGSFYLPRLEYSTLPMAVDRGVGWKTLRDAGPVVFM
NGWYYLTRREDVLAALRNPKVFSSRKALQPPGNPLPVVPLAFDPPEHTRYRRILQPYF
SPAALSKALPSLRRHTVAMIDAIAGRGECEAMADLANLFPFQLFLVLYGLPLEDRDRL
IGWKDAVIAMSDRPHPTEADVAAARELLEYLTAMVAERRRNPGPDVLSQVQIGEDPLS
EIEVLGLSHLLILAGLDTVTAAVGFSLLELARRPQLRAMLRDNPKQIRVFIEEIVRLE
PSAPVAPRVTTEPVTVGGMTLPAGSPVRLCMAAVNRDGSDAMSTDELVMDGKVHRHWG
FGGGPHRCLGSHLARLELTLLVGEWLNQIPDFELAPDYAPEIRFPSKSFALKNLPLRWS

CYP143A2P Mycobacterium leprae

1 MSTSAKANPTHFTYCSLNYSALSMITDRGVIWKTLXX 105
113 AKPVVFMNG*YYLNVSRKCILHTTSITKGFSSREAXXX 217
225 PGNALPVLPXXXXXXXXXXXXXXXXXXX 251
278 SLNNLNKALPALRTYTVTMANAITSRGEW 364
366 EAMTDFANX 389
391 LFPLQLFLVL*GLXX 429
434 AQDRDHLIALLKDVVIGMSDKPFLSQADIADQGELCEYLVDTIAERKQNPA 586
585 PDVLSQVLIGEDPLSEIKVLDLESL 659
659 MLILAELDTVTATVGFSLLQPACRQQLRTMLRDKPKQIRILIED 790
792 ILQLEPPAQITPYITTEFVNVDGMTLSPGSRVRLC 896
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
993 GSHLARLKLTLAVDEWLINI 1052
XXXXXXXXXXXXXXXXXX
1116 LFALKALALHW 1148

CYP143A3 Mycobacterium marinum MM2631

MSAPRDERDI PHFVYAELPM ATDRGRGWAT LRDAGPVVIG DGFYYLTRRD DVLDALRHPE
VFSSKRAFDI LGSPLPLVPL AFDPPEHTRF RKVLQPFFSP HALAAMLPSL QAQAIEIIDA
IAAGSQCEVI TELAIPYPSQ VFLTLFGLSL ADRDRLIRWK DAIIALGLLA SLDDADLTPA
LELTSYLVDA IAAHRRHPGT DILSQVLLGD DPLDDSEALG LSYVFVLAGL DTVTSAIGAA
LLELARRPQL RQLLRENHGQ IAVFVDEIVR LEPPAPVVPR VTTREVNIAG AKIPAGSRVW
LCLGAINRDG SDATSVNDVV MDGKVHKHWG FGGGTHRCLG SHLARMELSL VISEWLRRIP
QFELACGYTP EIDWPSATLG LSTLTLQFTS *

CYP143A3 Mycobacterium ulcerans

MSAPRDERDIPHFVYAELPMATDRGRGWATLRDAGPVVIGDGFYYLTRRDDVLDALRHPE
VFSSKRAFDILGSPLPLVPLAFDPPEHTRFRKVLQPFFSPHALAAMLPSLQAQAIEIIDA
IAAGSQCEVITKLAIPYPSQVFLTLFGLSLADRDRLIRWKDAIIALGLLASLDDADLTPA
LELTSYLVDAIAAHRRHPGTDILSQVLLGDDPLDDSEALGLSYVFVLAGLDTVTSAIGAA
LLELARRPQLRQLLRENHGQIAVFVDEIVRLEPPAPVVPRVTTREVNIAGAKIPAGSRVW
LCLGAINRDGSDATSVNDVVMDGKVHKHWDFGGGTHRCLGSHLARMELSLVISEWLCRIP
QFELACGYTPEIDWPSATLGLSTLPLQFTS

CYP143A4 Mycobacterium marinum MM2666

MSTPGEGSAS SFYLPRLEYS TLPLAADRAV GWNTLRDAGP VVFMNGHYYL TRREDVLAAL
RNPKIFSSRI LQPPGNPLPV VPLAFDPPEH TRYRKALQPY FSPHALGKSR PVLERHAAEM
IAGFAGRGEC DAMAEFARLY PFQVFLDLYG LPLQDRDRVI AWKDAIIGDK LYLTREELEV
GQLELLEYLN NAIQQRRQNP GSDMLSQVMT GPGEFTDLEL LGMSHLLILA GLDTVTAAIG
FSLLELARRP QLRTQLRDNP KEIRVFIEEI VRLEPSAPVA PRITTDFVNV GGMTLPPGSQ
VRLCMAAVNR DGSDAMSTNE LVMDGKVHRH WGFGGGPHRC LGSHLARIEL TVIVAEWLKQ
LPDFELAPDY SPEIAFPSKT FALKSLPLRW A*

CYP143A4 Mycobacterium ulcerans

MSTPGEGSASSFYLPRLEYSTLPLSADRAVGWNTLRDAGPVVFMNGHYYLTRREDVLAAL
RNPKIFSSRILQPPGNPLPVVPLAFDPPEHTRYRKALQPYFSPHALGKSRPVLERHAAEM
IAGFAGRGECDAMAEFARLYPFQVFLDLYGLPLQDRDRVIAWKDAIIGDKLYLTREELEV
GQLELLEYLNNAIQQRRQNPGSDMLSQVMTGPGEFTDLELLGMSHLLILAGLDTVTAAIG
FSLLELARRPQLRTQLRDNPKEIRVFIEEIVRLEPSAPVAPRITTDFVNVGGMTLPPGSQ
VRLCMAAVNRDGSDAMSTNELVMDGKVHRHWGFGGGPHRCLGSHLARIELTVIVAEWLKQ
LPDFELAPDYSPEIAFPSKTFALKSLPLRWA

CYP143A5 Mycobacterium vanbaalenii PYR-1

MSALPHVLYGDLPMAADRGAGWATLREFGPVAYGDGWYYLTRRDDVLAALRNPEVFSSRIAYDDMISPVP
LVPLGFDPPEHTRYRRILHPFFSPQALGVLLPSLQAQAADIVETIAQRDACEVMAELATPYPSQVFLTLF
GLPLQDRERLIAWKDAIIAFSLTNDPTSVDLTPAVELYGYLTEAVARQREKPREGILSHLLHGDEQLTDN
EAVGLSLVFVLAGLDTVTSTIGATMLELARRPELRAALLGDPDGIAGFVEEMIRLEPAAPVVGRVTTREV
TVAGVTLPKGAEVRLCLGAINRDGADEHSGDDFVLDGKLHKHWGFGGGPHRCLGSHLARMELRLVVTEWL
SRIPDFELAPGYVPEITWPSATCTLPTLPLILTRKTP

CYP143B1 Frankia alni ACN14a

MSAGEAQPLTFEDLPVRDDRDAAWRLIRERGGIVQLEPDVALTDHTLVEAAFRNPAVFSSRQAFDSLGSP
LPLVPIAFDPPEHARYRHILQPFFSPRSIRPLEPELRRQLAELIAPLPARGACDFVADVASVFPVQAFLT
FFGLPLDMRDQFVAWKDAILALSDPSGAISTDEADLRHAGELFTYLSELVAARRGVPGPDVLSELLCLDG
DDALTDAEVIGLCFLFVLAGLDTVTDALGFGMERLARNPDRRQEIVDDPGLVPAAVEELLRLDPPAPFVP
RITTAQTELGGRTLPAGTRVTAYIAACNRDEARYPDPYGVDFHRGDNPHASFGVGVHRCLGSHLARLEMR
LVYEEWHRLIPHYDIAPGFAPTVKFPRGTVGLEALPLVLTPGASR

CYP143B2 Frankia alni ACN14a

MTHKRDMRHSASHAWNESWVTRRAGERVEGTAMTDDRNNEKVTLSNLPIARDRDAAWRQLREHGRTVLLD
GGLAATDVETVETVLRQPAIFSSKKAFDVLGSPLPLVPIAFDPPDQTRYRRILQPFFSPRAIRPLEDELR
RQIVEIVEPLVRRGSCEYVSEVAGIFPVQVFLTLFGLPLEMRDQFIEWKDAILGLSDPSGNTALDEAATE
AAMATALGLFSYLADLVPARRGVAGDDVLSQLLCLEGDEALTDEEAVGLCFLFVLAGLDTVVDALSFGTD
RLIRNPDRRREIVDDPALIPAAIEELLRLDPPAPFVPRVTTEQTVLDGRTLPAGTRVTTNLAAANRDPAR
HPDPYTVNFHRGESPHLSFGAGVHRCLGSHLARLEMRLVFEEWHRLIPDYDLAPGASPQVKWPRGTLGLD
ALPLVFPASAPAAGAGGQAS

CYP143C1 SBI_7215 Streptomyces bingchengensis

51% to CYP143B2 Frankia alni ACN14a
MTSVDSDTVHVVRDLPVAERRDDAWRMLMARPEPAPMDNGLAVTSLAAVK
AVLKEPNRFSAKKAFDAVETGYPLIPLAFDPPEQTHYRRILQPFFGPRRI
RALEESLRAQAIDLVEAVKARGGCDFVADIAVPFPAQALLTLLGLPLADR
DRFIESKNAALELTADAAGELTLTDEERAARVEQTMALGNYLGELIQTRR
AQPGDDILSEILAIDGDDHLSDTEAMGVCLMLVLAGLETVTDALSLAMER
LATHPGRRRELVEDPSLVPAAVEELLRLDPPAPFLPRVTTEDVEIAGCPV
PAGTLVNTHLTTANRDETCWPRPHDIDFHRPDNPHTSFGVGVHRCLGTHL
ARLEMQLLFEEWHRRIPEYAIAEGTSPRARLVRANIGMESLRLTIPTA

CYP144A1 Mycobacterium tuberculosis

MRRSPKGSPGAVLDLQRRVDQAVSADHAELMTIAKDANTFFGAE
SVQDPYPLYERMRAAGSVHRIANSDFYAVCGWDAVNEAIGRPEDFSSNLTATMTYTAE
GTAKPFEMDPLGGPTHVLATADDPAHAVHRKLVLRHLAAKRIRVMEQFTVQAADRLWV
DGMQDGCIEWMGAMANRLPMMVVAELIGLPDPDIAQLVKWGYAATQLLEGLVENDQLV
AAGVALMELSGYIFEQFDRAAADPRDNLLGELATACASGELDTLTAQVMMVTLFAAGG
ESTAALLGSAVWILATRPDIQQQVRANPELLGAFIEETLRYEPPFRGHYRHVRNATTL
DGTELPADSHLLLLWGAANRDPAQFEAPGEFRLDRAGGKGHISFGKGAHFCVGAALAR
LEARIVLRLLLDRTSVIEAADVGGWLPSILVRRIERLELAVQ

CYP144A1 Mycobacterium bovis subsp. bovis AF2122/97,

NC_002945 complete genome 2001114..2002418
Gene = CYP144 1 aa diff
locus_tag = Mb1806

CYP144A1P Rhodococcus sp. RHA1 Rha02971

VLADTTLGGAELPAGSHLLLLWGAANRDPAVFERPDEIVLDRPHIRSHLAFGKGVHFCVASALARMEALAATTALLARTGRFALAADSEPRWVPSLSVRRHSALPLRLEQVTPED

CYP144A2 Mycobacterium smegmatis MC2

MTFGCMTPPEGLGLALFRPECIQDPYPLYRRMLDTAPVHPIADSGFYAVC
GWDAVNDAIARPENFSSNLTATMTYQADGTVGAFEMESLGGKSHVLATAD
EPAHTAHRKALLPQLAARRIRAFEPFILETANSLWHSHLHDGHIEWMSAV
ANRLPMMIVGRLIGVPDADVDKLVRWGYSATQVVEGLVGQDQLTQATVAV
MELAGYITDQFRHAAQDPQDNLLGDLATACATGEMDELTAQSMMIILFSA
GGESTASLIGSAAWILASRPDIQEHLRAKPELLGAFVEEVLRYEPPFRGH
YRHVVHDTTLGGVDLPAGSRLLLLWGAANRDPSHFDAPDEFRLDRSSAKS
HLSFGKGTHFCVGAALARLEALVVLRHLLHNTANITAGDTGPWLPSLLVR
RLAHLELVTT

CYP144A3 Mycobacterium vanbaalenii PYR-1

MTVGHTDLGLALFHDEFLQDPHPLYARMHAEAPVHRVGDSDFYAVCGWDAITEAVARPGDFSSNLTGAMR
YQADGTVSLLPLDTLGSPTQALATADDPAHAAHRKLLVPYLAAKRVRALETFAENTMHALWQQMPAGAPV
EWMAVVADRLPMTVVCKLIGVPAEDVDRIAAWAYASTQILEGRVDEHTLTAAGTAALELAGYISDKLGRA
SLDPGDNLLGCIATACAAGELNNLTAQVMLVTLFSAGGESTAALIGSATQIIATRPDVQRRLRADPGLIP
AFLEEVLRFEPPFRGHYRHVVRDCALAGKELTAGSRLLLLWGAANRDPARFDAPNEFQIERPNSKAHIAF
GKGAHFCIGAALARFEARIVIDLLLRHTSWVDAAGPGWWLPSLLVRRLDELPLTMT

CYP144A4 Mycobacterium ulcerans

MKVASDAMTFFGTESLQNPYPLYERMRAEGPVHRIADSEFYAVCGWDAVNDAISRPGDFS
SNLTATMTYSPDGKVAAFEMDQLGGPTHVLATADDPAHAVHRKLLVRHLAARRIRSLERF
VSETAERLWFDGLQGGRIEWMDAIANRLPMMVVAELIGLPDADIAQLVQWGYGATQLLEG
LVDQDQLADAGIAVMQLSGCITEQFARAAADPQENLLGELATACAAGELDSLTANLMMVM
LFAAGGESTASLLGSAVWILATRPDIQQQVRDNPQLLGAFVEETLRYEAPFRAHYRHVRN
DTTLGGLTLPADSHLLLMWGAANRDPVQFDAPEEFRLDRPGGKGHISFGKGAHFCVGAAL
ARLEAQIVLRLLLERTTVIEAADVGRWLPSMLVRRLENLELAVR

CYP144A4 Mycobacterium marinum MM2654

MKVASDAMTF FGPETLQNPY PLYERMRAEG PVHRIADSDF YAVCGWDAVN DAISRPEDFS
SNLTATMTYS PAGKIAAFEM DQLGGPTHVL ATADDPAHAV HRKLLVRHLA ARRIRSLERF
VSETAERLWF DGLQGGRIEW MDAIANRLPM MVVAELIGLP DADIAQLVQW GYGATQLLEG
LVDQDQLADA GIAVMQLSGY ITEQFARAAA DPQENLLGEL ATACATGELD SLTANLMMVM
LFAAGGESTA SLLGSAVWIL ATRPDIQQQV RDNPQLLGAF VEETLRYEAP FRGHYRHVRN
DTTLGGLTLP ADSHLLLMWG AANRDPVQFD APEEFRLDRP GGKGHISFGK GAHFCVGAAL
ARLEAQIVLR LLLERTTVIE AADVGRWLPS MLVRRLENLE LAVR*

CYP145A1 Nocardioides sp.

MSSVLAPESDVDLFAGEVLADPYPIYAALRSLGPVVWLPRHGFY
VVVRYAEAREVLNDHERFVSGRGVGFNQQFNDVRSGSIIASDPPRHDILRSVLNERLG
PRALKDTEVMIRSRASDLVAEMAQRRSFDAVKDFAEVFPVQVVGELIGLPEGSRGRLL
QWANGAFNAFGPSGERTAAGLEAIAEQFDYIRTVANREQLMPDSMGAAVYQAADEGII
SEDDCLPLLSAYLTAGMDTTVNALSAMLLLLSTDPDQWQELRSSPSLAPSVVNEVLRI
EAPAQLFSRVTATRVDLAGTRIEAGERVAVIYASANRDEKKYPDPDRFDIRRNPAGHL
AFGSGLHVCAGQFLAKTELRAVLDALIEQIETMTVGEPVRKINNVLRGLSSLPATFVP
VQTSR

CYP145B1 Streptomyces scabies SCAB90301

MISTTTPVSD VDLFADEVLD DPYPVYEELR DLGAAVHLSR HGCWVLPRYA QVRAALGDHG
RFSSVDSVGL DPALNERRRG GVLASDPPEH DVLRGVLSES LAPRALATLR TDIGRRAEEL
VAPLVERRTF DVVRDLARVF PVSVVADLIG MPLAAREEVL RFADAFFNTF GPLNDRTRQS
LPVAETLFDE LTAMMSRDNL EPGGWGQAVH RAADRGVIGE HQVVPLLRAY LVASMDTTIN
AIGSGLWLLA QRPGAWRSLR EDRSLVPSVF EEILRYESPV QMFFRRTTCP VRYGDVVIPE
QAQVSLLFGS ANRDPREWTD PDRFRVDRAP TGHVGFGYGV HGCAGQGLAR MEAQAVFSAL
LDRVDSIELA GPPRRHLNNV IRGLDSLPVT VTTRKV

CYP145C1 Streptomyces scabies SCAB90701

MPMRTEIPVY HPDLYAASAI RDTYPHYAAL RALGPVVHLS KHNVHALPRY AECKQVLLDD
DTFISSHGVA LNPVANRVGQ GTTLFSDGED HARRRSLLGH RLTPRALRTM KDTVDQQAAA
VVEDAVARRT VDAVEIATAL PMSVVPDLVG WPRQGREHLL RWAGATFDAL GPLNCQAART
LPASLGMLRY ARAVVRDRSV LDGSMGHDLL LAADEGRIMP AECATMMIDY LAPSLDTTIS
AISSALYLFA VHPEQWRLLK ADPDLAPKAV NEVVRYESPI RAFSRTAARD TEVAGIPLRK
GSRVLVLYGS ANRDPLEWDD PDTFDIRRDA ARQLGFGQGT HGCAGQGLAR METSAILRAL
IERVDRIEVT GPPEWALNNV IHRLGRLPLE LIPA

CYP146A1 Amycolatopsis orientalis

MQTTTAVGDLGNPDLYTTLDRHARWRELAARDAMVWSEPGSSPT
GFWSVFSHRACAAVLAPSAPFTSEYGMMIGFDRDHPDKSGGQMMVVSEQEQHRKLRRL
VGPLLSRAAARKLSERVRTEVSGVLDQVLDGGVCDVATAIGPRIPAAVVCEILGVPAE
DEDMLIELTNHAFGGEDELFDGMTPRQAHTEILVYFDELITARRERPADDLVSTLVTD
DELTIDDVLLNCDNVLIGGNETTRHAITGAVHALATVPGLLTGLQDGSADVDTVVEEV
LRWTSPAMHVLRVSTDDVTINGQDLPAGTPVVAWLPAANRDPAEFDDPDTFLPGRKPN
RHITFGHGMHHCLGSALARIELSVVLRVLAERVSRVELVKEPAWLRAIVVQGYAELSA
RFTGR

CYP146A2 Amycolatopsis balhimycina biosynthetic gene cluster for balhimycin, strain DSM 5908. Y16952.3 90% to CYP146A1

MFEESNALRGTEIHRRDRFAPGPELRSLMGEGTMSILQPPDSPG
GRTGWLATGHDEVRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMVTS
AFTVRRMQDFRPRIEQIVQASLDAIEAAGGPVDFVPRFAWSVATTVTCDFLGIPRDDQ
ADLSRALHASRSERSGKRRVAAGNKYWTYMTEIAARARRDPGDDMFGAVVRDHGDAIT
DAELLGVAAFVMGAGGDQVARFLAAGAWLMVEHPDQFALLREKPDTVPDWLNEVERYL
TSDEKTTPRIAQEDVRIGDQLVKAGDAVTCSLLAANRRKFPAPEDEFDITRERPVHVT
FGHGIHHCLGRPLAEMVFRAAIPALAQRFPKLRLAEPDREIKLGPPPFDVEALLLEW

CYP147A1 Myxococcus xanthus Partial missing C-term

MAQASIFEQILDPANRANPYPLYAELRKTPVAREADGTYIVSTY
DEIVALLHDPRVSSDIRNLVRQAGATPSPQEGPPGLPEPFIRRDPPDHDRLRKLAMRP
FGRTPPDALMPFVPGWSRPRRACLTRSRARTKSTSSDDVAYPFPVTVICKLLGVPRED
EARFHELADAGVETLDPTTGTIEQRKAKRDRTKAELGQYLAALADAHLRQPGGDLLSG
FLTDNGPDGRMSREEVLSTAALLLVAGHETTVNLIANGMLTLLRHPGVFERLRREPEL
SIPLVEELLRYEPPVQFLPDRVTLADIDIAGTTIPQG

CYP147B1 Streptomyces avermitilis

MASDTLLARITDYANRPDPYPLYAELREAGPVVRQADGSYLIGT
YHEIVALLHDPRMSADPRSRTAPAPYEVTRKPSFLRLDDPEHHRLRNSAMRPFGPPHS
PGRVDSMRGEIVQLTKELAEVFQEGRQIDVVDDFAYPLPVTVICRLLGIPDKDEQLFQ
DWTDTLVASADIGPEGDTAERDQAADQAQQEMGQYLVQLAEQRRGRPTGDMLSDLVNE
PDPAARLSEEDLAANTILLFIAGHETTVNLIANGVLTLLRRPDQLDRLREDPSLLPRA
VEELLRYEPPVHMRERVPLVDIDVAGTTIPGGTSVILALASGSRDPMRFSEPDRFDPT
RPDNQHVGFGSGIHLCFGAPLARIEAEAALGALLPHLGTARLVQDPPPYRQNAMLRGP
RHLPIQL

CYP147B2 Rhodococcus sp. RHA1 Rha05428

MSRAQLFQRITDQASRPNPYPLYEELRETRVAPQDNGSFLVGRYYDVKALLHDPRISSDLHNRGPGLPGADRAGDGPESFLKLDPPEHDRLRRLTTRQFGPPHSPDRIDSMRGELAALVTKLVDGLDGKERIDIVDDFAYPFPVTVICRLLGVPHEEEPRFHAWADALVAAIDPRRAGA
DNEQVKVAQKAQMEMAMFMAGLIEDRRRDPGDDMLSGLANDSGPDGQLNTVELVTNSILLFIAGHETTVNLITNGMLTLLRNPDVLERLRAEPELMPQAVEELLRFEPPVHLLGQRTPIVDIEIGGVTVPKGSPLVLALASANRDPERFVDADKFVPDRADNQHVGLGSGIHSCFGAP
LARLEGQMALAELIRRLPNPRLVEDPPPYRPNPVLRGPRHLLVDCG

CYP147C1 Streptomyces tubercidicus strain I-1529

VVEETPWQQALRYANRANPYPFYEELRKTPVARQPDGTYVVSTYQEIVALLHDPRVSSDVRKLPDPATAPAEGSAE
AEPITEAVILEPNIITQDPPEHDRDRRMMMPHFAGPPHSPHLISDLEPEIRRIVDGLLDTMQGKTRIDAVDEFAYP
LPVTVICKVLGVPLEDEPRFHSWIETALDALDFGPEAASEEIQSRRAGGRQAVEEFGQFAAELLDRYAQQPGPGML
SAMVNEDGPEGRMSKGVLVSNALLLIFAGHETTVNLIAHSVLTLLRHPDALEKLRRRPELIVPGVEELLRFESSVQ
FWHTRSAVEDIDIAGTTIPKGAPIFLAYGSANRDPKRFAHPDELDLERRDNQHLGFSQGIHFCFGAPLARLEVQAA
VGEFIRRVENPRLVEDPPPYRHNQIFRGPRHVLVDIDGIRD

CYP147D1 Magnetospirillum magnetotacticum

MCAPGPGRDPQCGTGRSSSGDPPDHDRLRGQVMRCFTPQRVRGM
REKTRRITDDLIAKMAGKTRIDLVDDFSYPLPVTVICELLGVPPEDEAQFHGWATQLA
TALEPNQRGDEETQAKNEVCFNEIADYIQGLIKEKRKNPQEDILSDLATDTDGMNDFD
LIATAVLLLVAGHETTVNLITNGMLTLLRFPEHLERLRAEPETAPRLIEELLRYEPPV
HYRTRLALADIPVAGITIPKDAPVILLLAAANRDPLRFSDPDRFDPDRPDNRHLGFGG
GLHYCVGAPLARIEAEVALVSLVRRLKGLSLTENPPPYRPGASLRGPCHLRLALEEVA
EG

CYP147E1 Methanosarcina barkeri Archaea; Euryarchaeota

MYRQGSGPNDRRQTMTQQSLYEQVLDYANRANPYPLYAKLRQTP
ITRQIDGSYVVSTYREIVSLLHDPRIGSDFRMRSA
HDRPSAGLSANQELASKNQAQDEGAETSSSNQGSETEVV
PSFIGLDPPEHDRLRRQATWPFGPPHTPGRVADMEPELILLA
NRQIDTIKGRTSIDIVEDFAYPIPVTMISELLGVPPEDQPRLHALSEAIIEDIDLDPR
QSPEEQKRRQEQSSQTFKELEQYMEVLIEHHRKQPGSDLLSGLITDHGSDGPMAQADL
VSTASLLLIAGHETTVNLITNGMLTLLRHPDVLERLRREPDLVIRLVEEFLRYEPPVQ
ILPNRVALSDITIAGTTIQKGSPVILLLASGSRDPARFHDPEKFDPDRRDNMHLGFGS
GIHYCYGAPLARLETQIALTELVQRLENPRLAHDPPPYRQSATLRGPRHLIVEIDGVK
DWEFHL

CYP147F1 Streptomyces peucetius

PSFLR
MTQSLLHQILDYANRADPYPIYEELRKTPVHHEEDGPYVVGTYYEIRSLLHDPRISSDAR
NLASTAGDPLAESAQEEDSALPPSFLRLDPPEHDRLRRMTNRSFGPPHSPHRVDGMRGEL
HGIVSGLIDGIGDTGRIDLVEQFSYPFPVTVICRLLGVPREDEARFHTWADTIAASLDPN
PDADPAERGKASHDARTQLGMYLAGLIEERRKNPGDDILSELATAKGRDGTMTTMELLST
AALLLIAGHETTVNLVTNGMLTLLRNPDVLQRLRADPRLAVPIVEELLRFEPPVQLVPQR
TTLTDIEVRGVTIPKGASLWLVLASGNRDPQRFEDPDRFDPDRRDIQHLGLGSGIHSCFG
APLARLEAHIALSELARRLENPRLLEDPPPYRQNAVLRGPRHLPIACDGIRP*

CYP147F2 SBI_7351 Streptomyces bingchengensis

57% to CYP147F1 Streptomyces peucetius
60% to CYP147F3 Streptomyces bingchengensis
MTLGSMSARINDYANRADPYPLFAELRKQPVIREDDGTYLVSTYYEVKSL
ANDPRLSNDTRNRAPGCARTGGSEENTGLPPSFIFTDPPEHDRLRGTANR
PFGPPHSPRFLHDLQADLAKVVTELLDAFEGKDQVDIVEDFSYPLPVTAI
CKVLGVPREDEPRFHGWADALAAGVDPHPGENGQERADTARQEMGSYLAD
LIDASRRHPRPGILSALAPHTGPGGRMTPKDLVATAVLLLVAGHETTVNL
ITNTTLTLLRHPDVLRRFQHDQDLATPLIEEVLRYEPPVQFVPWTTALAD
IDIADTTIPKGSPVWLMLAAANRDPRRFEDPDRFMPERKDNEHLGFYTGI
HYCFGAPLARIEAHLALPELFRRVKDFRLLEDPPPYRANAVLRGPRHLPV
AIEGVTA

CYP147F3 SBI_9076 Streptomyces bingchengensis

68% to CYP147F1 Streptomyces peucetius
60% to CYP147F2 Streptomyces bingchengensis
MTYGTYLRKITDPANRADPYPLYAELRKTPVLRDEGGPYLVSTYWEIHGL
LHDPRLSSDPRNLDPDAAAALAVTEEADDPTLPPSFLRLDPPEHDRLRRI
ATYPFGPPHTPRRIHDMRGELARIVTDLIDDFEGRDRVDLVDDFAYPFPV
TVICRLLGVPRADEPLFHAWADTMLTSLDPAAAEADVAQRRRAVRQARVE
LGMYLSELIEDRRRAPAEDMLSSLIHGDGPDGRMSHAELVSTAVLLLIAG
HETTVNLIANGMLTLLRHQDVLKRLHDDSRLAVPLVEEVLRYEPPVQLLP
HRTPLTDIDIAGVTIPKGAAIWLVLASGNRDPKRFPDPDRFDPDRKDNQH
LGFGSGIHICYGAPLARLEGQIALAELARRLENPRLLEDPPPYRHNAVLR
GPRHLPVGFDGVRPAREP

CYP147G1 Mycobacterium marinum MM2930

MNAETAWAEA MKFENRPNPY PYFDELRKTP VAKVAEKTYV VTGYRELLAL AHDPRISSDI
TRSPSGFGGE APQPEPGSEH VQAYGQDASI IVSDPPDHDR ARRQVMRHFA PPHSPDLIPS
MEPFVVRLAN DLLNQASARG STRLDVVEDF AYPIPVAVIC KILGVPIEDE PKFHAWIFDF
MAGTDLGPEG DTEEGQVLAE KGRVSTAALT DYLGDLVRSY AKTPGEGLLS KLLHDDGPDG
PMSVPETTAN ALLLLVAGHD STVNTITNCV MTLLRNPGSW DLVRQRPELI PRTIEEVQRL
QSAVQFFPSR SATDEIEIGG TVIPAGSAVH LIYAAANRDP RRFDNPNRFD PLREDNEHFG
WGSGIHTCMG GPLARLEVNL AVEIFLRRVQ SPKLVVDPPP YRHNQIFRGP RHLWVDFAAI TE*

CYP147G2 Mycobacterium vanbaalenii PYR-1

MTTASQAWAQAMAFAHRADPYPFFAELRKTPVARVADDLYVVTGYYELLALAHDPRVSSDFRRSPLSSDR
APAEPADDVGAYGSEPSLIVTDPPSHDRARRQVSRHFAPPHSPDLIPSMEPAVVALCNDLLDTAKANGRT
RIDVVDDYAYPVPVMVICKILGVPLEDEPRFHAWIFDMLAGVDLGPDATTDEGQGRAARARDAQAALRDY
LAGLIEGYRGAGGDGLLSALVNDASGPDGAMPPGQALANAVLLLIAGHDSTVNTISNCVLTFLRNPGTVE
LLRDRPELIPRAIEEVQRLQSAVQFFPSRSATADIEVGGTVIPEGAAVHLMYGAANRDPRRFADPDTFDI
FRPDNEHFGWGSGIHTCVGGPLARLEVNLALEIFLRRVHRPRLVSDPPPYRQSQIFRGPRHVLVDVEAIG
D

CYP147H1P Frankia sp. EAN1pec YP_001510211.1 ABW15305.1 58% to CYP147B2 Rhodococcus sp. RHA1 I-helix

MAELAAKRHDAPRDHMLSGLVSDDGPQGRMSQAEPITTAILLFVAGHETTVDLITDGMLIFLRHPELLEW MRREPDLMAGAVEELLRYEPPVHMLPQRTTLTDVEIAGTTIPRALRSP

CYP148A1 Deinococcus radiodurans R1

MTASSGSSAPSSGPLLAAVQGLWSGAALADPHPIYEQIRGFANA
DGLVRLPEWNTAFAVGHAATSAVLRSPAARSGEWDHGPSDGGKLLQHMMLFRNGIPHA
RLRGLVQKAFTPRVVEEQRDLVRSLLDELLSDMARAGGPVDLVAGLSGPLPGRVIMRM
LGLRGADEERFLGWSASVAELLGGADRSPALLARIEADAREMRGYFRDLADELRVSPQ
PGLLSALAAVEDGGERLSGDELLSNAVLLLAAGHETTSNLIPGGVLALSQQPGAWAAL
LNHPRHPGVADELLRHVSPVQLDGRMLTEAQTVGETPLPAGTPVQLLLAAANRDPQVF
PDPERLDWDRPNASRHLAFAAGPHYCLGASLARLEIAETFAALAERFPDLRVSAAPHY
KANFVLRGPQELWVTLG

CYP149A1 Microcystis aeruginosa

MIKQPIAIVGMGCRFPGANNPSEFWEILQNGVHKITKDPIDRPT
QMTGWAGFLDGIDKFDAAFFGIYSEEAIKMDPQHRLLLETSWEALEDAKLVPANLAGT
DTGVFIGLSGSEYPNLLIEDSTFNTTIGTLDCMLANRISSYFDFQGLSITINTACSSV
LVAIDSACQSLWNEDICLALVGGTHLTFSPVIASRASLNAMRPKIQAIVDDLLDRFAP
RGEMEIIADFATPLPAFAITKILGLPIEDYQQLIRWSAKTVFIFDQPVSLEEYKEQNQ
ILIEHRAYFAQKVAEYKRQPNDGLISQLANYNDNINALTEDEIISTSILLIATSQESM
KGLLSNGLLALLKHPQSLEYVRQNPGNIENIVEELLRYDSPIQYVSRRAIEDVEVSGK
IIHRGEYVVIYLGAVNHDPEYFSNPQQLDFSRRKPNLGFGGGLHYCVGMFLARLQVQI
ALNAMVQRFPDICLNTDKLDWCDSKISRRLKTLPVKFTPVA

CYP150A1 Mycobacterium species

MSDFDTIDYFTDPALVPDPHPYFDHLRAQCPVVKEPHYGVLAVT
GYDEAATVLKDNETFSSCIAVAGPFPPLPFTPEGDDITDQITAHRPQMPMFEHMVTMD
PPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDFVTDGRCEFLTAFAKPFSLLV
IADMLGVPEEDHDEFRAVLGAPRPGANVGSLDHSDLVGTNPLEWLDEKFIGYLEDRRR
EPRNDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASMRVLGDHPDV
QERLRRDRSRIPVFVEEALRMDAPVKSQFRLAKKNTKVGDMNVPAGTTMMVCPGAVNR
DPNRFEHPHEFDLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMADIQID
EELHGPPGARRYTYEPTFILRGLTDINITFSPVG

CYP150A2 Mycobacterium smegmatis mc2155

MTDSTATDPAATTPDFDTVDYFTDQSLVPDPHPYFDHLRSKCPV
VREPHYGVLAITSFEEATTVLKDTETFSSCIAVGGPFPPLPFTPEGDDITGQIEQHRT
QLPMFEHMVTMDPPEHTNARSLLNRLLTPKRLKENEDFMWRLADECLDDFIDDGSCEF
LKQYAKPFSLLVIADLLGVPEEDHDEFRHVLGAPRPGAIVGSLDGDQLAMNPLAWLDD
KFVRYLEDRRKEPRDDVLTALATAKYPDGSTPEVIDVVRSATFLFAAGQETTTKLLSA
SLRVLGDRPDIQQALREDRSRIPTFVEEALRMDAPVKSQFRLAKKTTQLGGVDVPAGT
TLMVCPGAVNRDPVRFEDPHTFSLDRKNVREHIAFGRGVHSCPGGPLARVEGRVSLER
ILDRMADIRIDEEHHGPADNRRYTYEPTYILRGLTDLHIKFEPVR

CYP150A3 Mycobacterium smegmatis

mtakrrcgnvilnnerhvlirlspsgngvth
MAIDPAGIDWFKDPRLVDDPYPYFNALRDKCPVQSEDHYGVTMVTGWEEA
VSVYNDEKSFSSCTSVTGPFPGFPVPLEGRDDVAELIEKHRDELPFSDQL
PTLDPPVHTNHRSLMMRLITPKRLKENEDAMWQLADEVLDDFLAPGKGEF
IKGFASPFTLLVIADLLGIPAEDRNAFVDGISQNSGGGVGSTGDESLSHS
PLEFLYGQFEAYIEDRRSNPREDILTGMATALFPDGTTPSPGDVARVATN
VFSAGQETTVRLLGTALKVLGDRPDVQKMVREDRSLLPNFIEEALRHESP
VKGDFRLSRCPVTVGDKDLPSGRTVMVVNGAANRDPRRFENPDDFDPARK
NARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTTDIRISEEHHGPAA
NRDYKYIPTFILRGLTHLHLEFDVK

CYP150A4 Mycobacterium smegmatis

MTDLASVDYFSDPAVAQDPYEYYDFLRSRGPVTTEPHYGVVAVTGYQEVM
AAFKDHDSFSAVNAIGGPFPPLPFTPEGDDITEQIEAHRHLFPIHEHMVV
MDPPAHERARSLLSKLLTPRRLKENEDFMWQLVDRQLDAIIGNQADEGRC
EFLSEYAKPFATSAIIDLLGVPEEDRAEFLEALGAAPREGARVGALDGEP
VGLDPLQYLDCKFAGYLAERRREPRGDVLSGMATATYPDGSTPDLMEVVK
PATFLFAAGQETVTKLLSSAVQTLAERPEFQERLRKEPDLIPVFIEEALR
TQSPTKVDFRLARKTTTLGGVEIKAGTVLMLCLGAANRDPRKFEDPHEFR
IDRPNVREHIAFGRGIHTCAGAPLARVEGQITVRRMLDRLRDIRIDATRH
GPADSRTYAYEPTFLLRGLTKLHIEYTPA

CYP150A5 Mycobacterium marinum MM4737

MNDCAEPDFF RDSGLVENPY PYYETLRQRC PVTGEGHHGV TMVTGWDEAV SVLNDAETFS
SCISVTGPFP GFPVPLEGDD VTELIERHRS ELPFSDQLPT LDPPTHTNHR ALLMRLITPK
RLKENEDAMW VLADRVLDDY LAAGEGEFIK GFASPFTLLV IADLLGVPPE DRQTFVNNIH
HHAGGGVGGT GKEALAHNPL EFLYGAFADY VRDRRREPRE DVLTGLATAT FPDGTVPDVE
DVARVACNVF SAGQETTVRL LGAALQIIGE RADIQQQLRR DRSLIPNFIE EALRIESPVK
GDFRLSRVPT TVGEVDLPAG TTVMVLQAAA NRDPRRFVEP ATFDPARKNA RQHLSFGRGI
HSCPGAPLAR AETRVAIERL LDRTADITIS ERVHGPANDR RYQYVPTYIL RGLTELHLDF TPA*

CYP150A6 Mycobacterium marinum MM4694

MSSYESIDFF TDPSLIPDPH PYFDYLRSQS PVLRLPQYGV VAVTGYEEAT AVYKDTDSFS
NCVALGGPFP PLPFAPNGDD VNAQIDAHRE QFPMYEHMVT MDPPEHSRAR SILSRLLTPS
RLKQNEEFMW RLADRQLDEF LGAGECEFIS EYAKPFATLV IADLLGVPED DRKDFRVVLG
ADRMGRVGAL DHESVGVNPL QWLDDKFSAY IEDRRRQPRN DVLTALATAT YPDGSTPEVI
DVVRSATFLF AAGQETTAKL LTAAMRVLGD RPDIQRRLRE NRSLIPNFIE ESLRMDSPVK
SDSRLARKRT TVGGLDIAAG TVVMVLPGAA NRDPRRFEDP HEFRLDRPNV REHMAFARGV
HSCPGGPLAR VEGRVSLERI LDRMLDIAIN EDRHGPADDR RYTYEPTYIL RGLTELHITF
TPAG*

CYP150A6 Mycobacterium ulcerans

MSSYESIDFFTDPSLIPDPHPYFDYLRRQSPVLRLPQYGVVAVTGYEEATAVYKDTDSFS
NCVALGGPFPPLPFTPNGDDVNAQIDAHREQFPMYEHMVTMDPPEHSRARSILSRLLTPS
RLKQNEEFMWRLADRQLDEFLGAAECEFISEYAKPFATLVIADLLGVPEDDRKDFRVVLG
ADRMGRVGALDHESVGVNPLQWLDDKFSAYIEDRRRRPRNDVLTALATATYPDGSTPEII
DVVRWATFLFAAGQETTAKQLTAAMRVLGDRPDIQRQLRENRSLIPNFIEESLRMDSPVK
SDSRLARKRTTVGGLDIAAGTVVMVLSGAANRDPRRFEDPHEFRLDRPNVREHMAFARGV
HSCPGGPLARVEGRVSLERILDRMLDIAINEDRHGPADDRRYTYEPTYILRGLTELHITF
TPAG

CYP150A7 Mycobacterium vanbaalenii PYR-1

MSDFDTIDYFTDPSLVPDPHPYFDHLRSKCPVVREPHYGVLAVTGYEEAATVLKDSDTFSSCIAVAGPFP
PLPFTPEGDDITGQIAAHRSQMPMFEHMVTMDPPDHTNARSLLNRLLTPSRLKENEDFMWRLADEVLDDI
ISRDPVGRCEFLSAYAKPFSLLVIADMLGVPEADHEEFRTVLGAPRPGANVGSLDHSDLVGANPLEWLDE
KFIGYLEDRRKEPRDDVLTALATAKYPDGSTPPVIEVVRSATFLFAAGQETTTKLLSASLRVLGDHPDIQ
ERLRRDRSRIPIFVEEALRMDAPVKSQFRLAKKNTRVGDMDVPAGTTMMVCPGAVNRDPSRFEHPHEFDL
DRKNVREHIAFGRGVHSCPGGPLARVEGRVSIERILDRMGDIAIDEELHGPPGARRYNYEPTFILRGLTD
LNITFTPVR

CYP150A8 Mycobacterium vanbaalenii PYR-1

MTDLASADFFSDYALSQDPHPYWDHLREQNPVYREPHYGVVAVTGYQEVLAAFKDHDSFSAVNAIGGPFP
PLPFTPEGDDITEQIEAHRHLFPIHEHLVVMDPPAHERARSLLNKLLTPRRLKENEDYMWQLVDSQIDQV
IGKGRCEFLSEYAKPFATSAIIDLLGVPEEDRPEFLAALGAEQPDGARVGALDGEPVGLDPLQYLDDKFA
GYLAERRREPRGDVLSGMATAVYPDGSTPELIEVVKPATFLFAAGQETVTKLLSAAVKTLAEQPEYQRIL
RAHPDRIPTFIEESLRMNAPTKVDFRLVRKTTTLGGVHLKAGTIVMLCLGAANRDPRKFEDPHEFRPERK
NVREHIAFGRGIHTCAGAPLARVEGQITVRRWLDRTDEIHLDESVHGPAGQHHFAYDPTFLLRGLSQLNI
EFTAAT

CYP150A9 Mycobacterium vanbaalenii PYR-1

MAEDLTTVDFFRDSRLTDDPYTFYEALRNKCPVSREEHYGVTMVTGWQEAVDVYNDAESFSSCVSVTGPF
PGFPVSLEGRQDDDITALIEQHRDEIPFSDQLPTLDPPTHTNHRALLMRLITPKRLKENEDAMWQLADDI
LDDYLAQGEGEFIKGFAGPFTLRVIADLLGVPEEDRPELLERLAKGTHGGGLGNADKTLTKTPLEYLYDV
FATYVEERRAEPRDDVLTGLATANFPDGTVPEVGDVVRVATNVFSAGQETTVRLLSTALKVIGDRPDIQE
RLRADRSLLPNFIEECLRIESPVKGDFRLSRVPTTIGDQALGAGCTVMVINGAANRDPRRFEDPDAFDPE
RKNARQHLAFGRGIHSCPGAPLARAETRVGLERLLDRTSDIRISESKHGPAGNRRYDYIPTYILRGLTEL
HLEYDVR

CYP150A10 Mycobacterium vanbaalenii PYR-1

MTEQLTPTDIDEVDFFTDNTVLHDPYGYLAAMRNECPVRRERHHDVVMITGYEEAVAVYNDNARFSSCTA
VTGPFPGFPVPLVGDDVSGLIAEHRDKLPFNDQLPTLDPPLHTDHRALLSRMITPKRLKENEEFMWRLAD
RQYDEALAGGRCEFVGEFGNPFAMLVIADLLGVPESDHNDFKDQLLTSTGTIGSSGGDAMHHSPLEYLYG
KFTDYITDRRENPRDDVLTGLASALFPDGRTPPVIDVVCVAANLFAAGQETTVRLLSTAVMMIAEDPALQ
AKLRADRSLIPGFVEEALRFESPIRGDFRLSKVPVSVGGVELPAGTTVMLNNAAANRDPRRFTDPDTFDL
QRPNARQHIAFGRGAHSCPGAPLARAEAKVSINRLLDRTSDIWIDEDKHGPVDARRYKYLPTFILRGLTR
LHIEFS

CYP150A11 Frankia sp. EAN1pec

MREFEAMDFFRDETLVADPYPYLDALRRKCPVQRERHHDVVMVTGYEEAVEVFHDSEAFSSCVSVTGPFP
GFPVPLDGDDVSALIERHRHELPMNDQLPTMDPPTHTDHRALLMRLITPKRLKENEALMWDLADRMLDPF
LTPGEGEFISGFAGPFTLLVIADLLGVPEEDQDEFLDKLQRQPAQTGGVGGTGAETLAHSPLEFLYGKFT
GYIEDRRRNPRADVLTGLAGATFPDGSTPEVIDVVRVAANLFSAGQETTVRLLSSALKILAERPDLQRQL
RVERERIPAFIEETLRWESPVKGDFRLSRVPVTVGGVQLPAGTTVMVVNGAANRDPRRFENPETFDVARS
NARQHLAFGRGIHSCPGAPLARAEARASLERLLDRTTDIRVNERVHGPAGNRRYEYMPTFILRGLTALHL
EFDLAPAPPRDFPPAGSPVGWIKG

CYP150A12 Frankia sp. EAN1pec

MSELETKDFFRDEELVADPYPFLEAMRGKCPVQRENHHDVVMVTGYDEAVQVFHDSATFSSCVSVTGPFP
GFPVPLEGDDVTELIERHRGELPMNDQLPTLDPPTHTAHRALLMRLITPKRLKENEAQMWRLVDQMVEPY
LAGGEGEFITGFAGPFTLLVIADLLGVPEEDQEEFLDRLQRQPQESGGIGSTGDDHMAHNPLEFLYNKFT
AYIEDRRREPREDVLTGLALATFPDGSTPEVIDAVRVAANLFSAGQETTVRLLSSALKILAEDRELQQLL
RAEPDRVGNFIEETLRLESPVKGDFRLSRVPTTVGGVDLPAGTTVMVVNGAANRDPRRFENPSVFDVARP
NARHHVAFGRGIHTCPGAPLARAEARASIERLLERTTDIRISESVHGPADDRRYSYLPTFILRGLTHLNL
EFTLAESKTP

CYP150A13 Frankia sp. EAN1pec

MKDIEAIDFFRGDELVADPYPYFHALREQCPVRREPHHGVVMVTGYEEAVSVFHDSDRFSSCTSVTGPFP
GFPVPLEGLEGDDISELIERHRAELPMSDQLPTFDPPMHTDHRALLMRLITPKRLKENEEFIWRLADRLL
DEYLASGEGEFIRGFAGPFALLVIADLLGVPEEDHEEFTDRLQHRPAEGGGVGSTGDHSMEHSPLQFLYD
RFTTYIEDRRREPRDDVLTGLATATFPDGSTPEVIDVVRVAANLFSAGQETTVRLVSTAAKLIADNPGLQ
RLLRAERDRIPNFIEETLRLESPVKGDFRLARVPTTVGGVDIPAGSTVMVVNGAANRDPRRFADPDTLDV
ARPNARQHIAFGRGIHSCPGAPLARAEARAGLERLLDRTADIRISERVHGPAGARNYQYLPTFILRGLTH
LQLEFTPAASDSR

CYP150A14 Frankia sp. EAN1pec

MTDWTTTDFFNDESLAEDPYPYFDELRSVCPVLPLPHLGVVAVTGYDEAHEVYRDVDTFSSCNSVVGPFA
TFPVPLEGDEVGAIIDRHRDQLPMNEHMVTMDPPMHTRERALVMRMLTPKRLQENEAFIWRLADQQLDEF
IADGRCEFIRAYAQPFSMLAVADVLGVLESDHQRFREGFGLTVSPGQIGAGEQTDGELNALGWLDAWFAR
YIESRRHEPRNDVLTQMAAATYPDGTTPEVTSVVRAATFLFAAGQETTARLLGAALKFIAENPGLQEEIR
EHRERIPDLIEETLRVESPVKADFRLARRTTTIGDVEVPAGTPVMLLNGAANRDPRQFECPAEFRISRRN
VRQHIAFGRGIHSCPGGPLARVEGRISLERILDRTRDIRISEEHHGPPDARRFDYEPTWILRGLTNLHLE
FTPVESAR

CYP150A15P Frankia sp. EAN1pec YP_001505067.1 ABW10161.1 59% to CYP150A2 Mycobacterium smegmatis

MSDWKTIDYFTDESLVADPYPYFDELREAGPVLPLPHLGMVAVTGYEEASQVYREAETFSSCSSVVGPFA
TFPVPLEGDDVSEIIDRYRTRLPMFEHMVTMDPPDHTRERALLMRLLTPRRLKENERFISRQADRQLDEF
IDRGTCEFVREYAQPFTMTGPLTSGCPKSTTGRRVPGVSPTTPPGSCAA

CYP151A1 Mycobacterium smegmatis

MSSTTLDSVPSFDVTDPAFSITSDEVHEAREKSWYATTPYGLAV
LRYEQVNRLIKHPKLRQGSAAWPAHNGVTEGPFAEWFASWILNKEGEEHHRLRRLMNP
AFSPKLIGSLVPRFQALANELIDNFAEPDRCEFVSEFAEPYAARVIAIMLGLPEEEWK
VISTESATIGLALGVTLREDLPKIEAAVQRLYEYSDELIADRRANPRDDFMTTLVNAS
RPDDGRLSDKELRDAILLLIFGGFDTTRNQLGLAMQTFMKHPDQWRLLGERPDLGGKA
VEEVMRVNPTVRWVTREVVEDFEYEGVTLKAGTTVHLYSESAGTDPRVFEPGFDITAE
RKPHFGFGGGVHHCLGHFVARSDMSEALPLLARRLRDPHELPGATWLPDSGNTGPNTL
PIGFTPAP

CYP151A2 Mycobacterium sp. strain RP1

MSSLALGPVAAFDVADPSFSITSNEVHAARERSWYATTPYGIAV
LRYEQFSRLLKHPKLRQGSVAWPAHNGVTEGPFAEWFASWILNKEGEEHHRLRRLMNP
AFSPKLIGSLVPRFQALANELVDNFAEPYRCEFMSEFAEPYAARVIAIMLGIPEDEWK
VISTEAATMGLCLGVTLGKDLPKIEAALQRLYEYCDALITDRRANPREDFVTALVEAS
REEDGRLSDTELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGKA
VEEVMRVNPTVRWVTREVLEDFEYEGVLLKAGTTVHLYSESAGTDPRVFDGSFDITAE
RKPHFGFGGGAHHCLGHFVARSDMSEALPLLARRMRDPQALPGATWLPDSGNTGPIQL
PIGFTPAR

CYP151A3 Mycobacterium vanbaalenii PYR-1

MSSATVGSVPAFAVTDPGFSITSAEVHAARERSWYATTEYGLAVLRYEQVNRLLKHPKLRQGSAAWPAHN
GVTEGPFADWFAGWILNKEGEEHHRLRRLMNPAFSNKLIGGLVPRFQALAAELIDGFAEPGRCEFVGEFA
EPYAARVIAIMLGLPESEWKVIATESATIGLALGVTILDDLPRIEAALAHLYEYCDELIADRRASPRDDF
VTTLVNASRPEDGRLSDNELRDAMVLLIFGGFDTTRNQLGLAMQTFMAHPDQWRLLAERPELGGNAVEEV
MRVNPTVRWVTREVLEDFEYEGVELAAGTTVHLYSESAGTDPRVFEPGFDITAERKPHFGFGGGVHHCLG
HFVARSDMSEALPLLARRMLDPHELPGATWLPDSGNTGPITLPIGFTPAS

CYP152A1 Bacillus subtilis

MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK
NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL
MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK
ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA
FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER
EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF
RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS
LHYSLARMPSLPESGFVMSGIRRKS

CYP152A2 Clostridium acetobutylicum

1 MLLKENTAKD KGIDSTLDLL KEGYLFIKNR ADHYQSDLFE TRLMGQRIIC MTGEEAARIF
61 YDSDKFKRQG AAPKRVQETL LGENAIQTLD GESHLHRKKL FMLLTNQVQQ KRLAELTTEK
121 WEASASKWHT KSIVLFNEAN EILCQVACHW AGVPLMESDI KNRAEDFSSM IDSFGAVGPR
181 HWKGKKARNT IEAWIKEIIE NVRSGRIRAE EGSPLHEIAF YIDVNGQQMP AEMAAIELIN
241 ILRPIVAIST FITFSALALY EHSEYREKLQ SKDIRYLEMF TQEVRRYYPF APFVGARVRK
301 DFLWNNCEFK KEMLVLLDIY GTNHDSRIWQ KPYEFIPDRF RSYKGNLFDF IPQGGGDPSS
361 THRCPGEGIT LEIMKTSLDF LSTKIDFTVP DQDLSYSLSK IPTLPKSGFI IDNINLKL

CYP152B1 Sphingomonas paucimobilis

MPKTPHTKGPDETLSLLADPYRFISRQCQRLGANAFESRFLLKK
TNCLKGAKAAEIFYDTTRFEREGAMPVAIQKTLLGQGGVQGLDGETHRHRKQMFMGLM
TPERVRALAQLFEAEWRRAVPGWTRKGEIVFYDELHEPLTRAVCAWAGVPLPDDEAGN
RAGELRALFDAAGSASPRHLWSRLARRRVDAWAKRIIEGIRAGSIGSGSGTAAYAIAW
HRDRHDDLLSPHVAAVELVNVLRPTVAIAVYITFVAHALQTCSGIRAALVQQPDYAEL
FVQEVRRFYPFFPAVVARASQDFEWEGMAFPEGRQVVLDLYGSNHDAATWADPQEFRP
ERFRAWDEDSFNFIPQGGGDHYLGHRCPGEWIVLAIMKVAAHLLVNAMRYDVPDQDLS
IDFARLPALPKSGFVMRNVHIGG

CYP152B2 Azotobacter vinelandii

MHRIPRDKGLDSTLALLHDPYRFIARRCRLHGSNLFETRLLLRKTLCMSGAEAARLFYDP
ERFVRHGAMPPRLQKTLFGVGGVQGLDGEAHRHRKHMFVALLMDAERVAQLVEAVRGEWR
TCARRWERMEKVVLYD
CAWAGIPLAEEEAGPRAREIALLFDYAGSVGPKHWRSRLARRRSEAWMGALVESIRASRR
QPPAETAAQVISWHRGLDGNLLEAR
VAAVELLNVIRPVVAIAVYLTFVAHALHRYPHCRHGLRSGDAEYREWFVQEVRRFYPFFPA
VVARVRQDFEWRGYAFPAGRRVMLDLYGTDHDVRLWQAPETFRPERFGSREYGPCDFIPQ
GGGEHESGHRCPGERIVMKLGADVLARELSYAVPMQNLEIDFSRLPALPRSRFVMSDIHGAP*

CYP152C1 Rhodobacter sphaeroides

MTTDEGRRPEEPGTPASLREMPRDPRIDASMALMSEGYRFVSNL
CDRMDSDAVATRLRLREVVCLRGSAAARLLYGAEGLTRVGAMPSTVLHLLQDKGSVQQ
LEGPAHRHRKALFLSICMDPARVEALVSEMRLAWRERLPAWEAEGRIVLQQEAARLLT
RAGCRWAGVAHQPEAQLADEIFDMIDKAGSVGPRNWLAQMRRAGTEKRLRTLVEEVRA
GEVVPEAATALHAIAFHREEDGTLLDPSVAAVELLNLLRPIVAVGRYITFAALALHRE
TTWRELFRSGNLELAGDFAEEVRRASPFFPFTAAVTTRPITWEGYDFPEGQWLLLDLY
GTTHDPRHFPEPTRFRAERMLSWTGQDEAFIPQGAGDVARTHRCPGEMITVELMKEAI
RLLCCEMDYEVPAQDLGVRLNRMPAQPRSGMILSAISRRAGTEASRNG

CYP152C2 Rhodobacter sphaeroides

MSNSDARHEA GPSDTTCGRE IPRDPRLDAS MGLLSEGYRF VSNLCDQLDS DIVSTRIRLR
EVICLRGGTA ARLLYGAEGL TRVGAMPSSV LHLLQDKGSV QQLEGPAHRH RKALFLGICM
DPARVEALVA EFRAAWRAAL DEWEEADSIV LQQEAARVLT RAACRWAGVE NQPEARLAEE
IFDMIDKAGS IGPRNWLAQM RRSGTERRLR KLIEQVRAGE VVPGSATALH AIAFHREADG
ALLDDTVAAV ELLNVLRPIV AVGRYITFTA LALHRETNWR DLFRSGTLEL AADFAEEVRR
ISPFFPFTAA VTTRPLQWEG YDLPADQWLL LDLYGTLHDA RNFPDPARFR AERMLSWSGQ
DDCFVPQGGG EVAVTHRCPG EMITVELLKE AIRLLCLEMD YEIPPQDLGV RLNRLPAQPR
TGMVLASIRR RPGTEPCVAG

CYP152D1 Streptomyces scabies fSCAB80661

MGMMHSRRTP LVDSSLSLLV RGYTWLPDRR RRTTGPLVRA RLTGRPAVAL RGPEAVRFFY
DERHVERASA LPGPVLGTLF GHGAVHTLDG PPHRVRKDLF LSLLTGPKAV AGLVDHVTRA
WDAAEASWPH RPSVVLFDEA SRVLTLGVCR WAGIPLHDRD ADGAAPAADL VAMVDGFATP
GPRHWRARRA RGRREAWLAR LVSDVREGAA TAPAGSALDV VARHEDADGL PLDPHTAAVE
LLNVIRPTVA VCWFVAYAGH ALHLRPDVRE RLAEADPEYA VAFAHELRRF YPFAPFVGGR
AVTDLEWRGE PIPAGALVLL DLYGQNHDPG QWDLPYTFEP QRFLERPPGR DDLVPQGGGD
RATGHRCPGE DVTVALLRTL GPRLARLEYA VPPQDLRIPL TRMPARVRSG FVMESVRVPE
RVRVAGRAAG

CYP152E1 gi|126657198| ZP_01728364 Cyanothece sp. CCY0110

MIKKIPQDKWIDSSLALIFDGYDFISKRCKRYQSNIFQTRLMLEKTICFKGEEAAKIFYDKTKFTRKNAA
PDRVKKTLFGEKGIQGMDGDAHLHRKQMFMSLMSKERIQEVGTLTQKQWHNYAKKWERMDTIVLFEEARE
VLCRVACTWAGVPLEESEVKLRSQQFEAMIAGSGVVGPKHWQGRKARKENEQWIETIIEKVRNHQLEVPE
ISATYIFANHRDLSGELLDKRVAAVELINVLRPIVAIDRYITFGALALHEHPECRPKLLESEDYLRAFVE
EIRRFYPFFPFASARVRQDFDWQGYHFPEGTRVLLDLYGTNRDPQSWDKHDVFYPERFLNFSELDSFKFI
PQGGGDYHTNHRCPGEWITIELLKVTMTFLIQSINYNVPKQDLRINHLKMPTVPASGFVIKNVNLC

CYP153A1 Acinetobacter calcoaceticus

MNSVAEIFEKITQTVTSTAADVATTVTDKVKSNEQFQTGKQFLHGQVTRFVPLHTQVRGIQWMQKAKFRVFNVQEFPAFIEQPIPEVATLALAEIDVSNPFLYKQKKWQSYFKRLRDEAPVHYQANSPFGAFWSVTRYDDIVYVDKNHEIFSAEPVIAIGNTPPGLDAEMFIAMDPPKH
DVQRQAVQDVVAPKNLKELEGLIRLRVQGVLDQLPTDQPFDWVQNVSIELTARMLATLFDFPYEKRHKLVEWSDLMAGTAEATGGTVTNLDEIFDAAVDAAKHFAELWHRKAAQKSAGAEMGYDLISLMQSNEATKDLIYRPMEFMGNLVLLIVGGNDTTRNSMTGGVYALNLF
PNEFVKLKNNPSLIPNMVSEIIRWQTPLAYMRRIAKQDVELNGQTIKKGDKVVMWYVSGNRDERVIERPDELIIDRKGARNHLSFGFGVHRCMGNRLAEMQLRILWEELLQRFENIEVLGEPEIVQSNFVRGYAKMMVKLTAKA

CYP153A2 Caulobacter crescentus CB15

1 MMSQNTDPRE DLMSDGSIDL KADARARAYS IPLEDYHVAD PALFQADAMW PYFERLRKEA
61 PVHYSKGDEE VGPYWSVTRY NDIMTVDTTH QVFSSDAHLG GITIRNFDED FVLPMFIAMD
121 QPKHDIQRKT VSPIVSPANL GRLEGIIRER VCGILDALPI NEPFDWVDKV SIELTTQMLA
181 TLFDFPWEER RKLTRWSDIA TASPESGLIE SEEARRAELL ECLAYFTNLW NERVNLTEPG
241 NDLISMLAHG EATRDMPPME YLGNVILLIV GGNDTTRNSL TGGLYALSKN PQEEAKLRAD
301 PGLIPNMVSE IIRWQTPLAH MRRTALEDYE LAGQTIKKGD KVVMWYVSGN RDDTVIENAD
361 QFIVDRPNAR RHLSFGFGIH RCVGNRLAEM QLKIVWEEIL KRFPKIEVLE EPKRVYSTFV
421 KGYERMMVRI PERI

CYP153A3 Bradyrhizobium japonicum USDA 110

1 MHYCKDSMFG PYWSVTRYND IMEIETNHSV FSSASALGGI TIRDIDPDLR RESFISMDPP
61 RHAAQRKTVA PMFTPTHLDN LALNIRARSA ECLDNLPRGE VFDWVDRVSI ELTTQMLAVL
121 FDFPWEDRRK LTRWSDIATT IPGPDGLVAT EDERQAELTE CAGYFARLWK ERIEQPPKSD
181 LLSMMAHGAA TRDMDAKNFL GNLVLLIVGG NDTTRNTMSG SIYALSQHPE QYRKLRENPA
241 LLDSFVPEVI RWQTPLAHMR RTALSDFEFR GKQIKKGDKV VMWYVSGNRD EEAIEKPYDF
301 IIDRARPRTH LSFGFGIHRC VGLRLAELQL KIIWEEILKR FDHIDVVGEP KRVYSSFVKG
361 LETLPVKIAA

CYP153A4 Bradyrhizobium japonicum USDA 110

1 MDGRRRRPMP LPQAGEVRKT TGATTMNIQT PVKVDKAERM RRARGEAYAT PLAQFHPGAP
61 RLFQDDTLWP WFERLRKEEP VHYCTNAPIE PYWSVVKYND IMHVDTNHGI FSSDSTLGGI
121 SIRDVPEGYD YPSFIAMDQP RHSAQRKTVS PMFTPTHLDE LAKLIRQRSQ TVLDNLPRNE
181 TFNFVERVSI ELTTQMLATL FDFPWEERRK LTRWSDVSTA LPKSGIVASA EERRREMDEC
241 YAYMSKLWNE RVNSAPRNDL LSLMAHNDAT RFMDPDNLMG NIILLIVGGN DTTRNTMTGS
301 VLALNENPEQ YDKLRANPAL IDSMVPEVIR WQTPLAHMRR TALQDTEIGG KQIKKGDRVV
361 MWYVSGNRDE EAIDRPNEFI IDRPRPRTHL SFGFGIHRCV GMRLAELQLK IVWEEMLKRF
421 DRIEVVGEPK RIYSSFIKGY ESLPVRIPG

CYP153A5 Rhodopseudomonas palustris

MTWPGRTTMHGTIETGKAARLRAAREEAYATPLKDFHPGAPRHF
RDDTLWPWFERLRAEEPVHYCTNAPIEPYWSVTKYNDIMHVDTNHQIFSSDSTLGGIS
IRDAPVGYDWPSFIAMDEPRHSAQRKTVSPMFTPQHLDELAVLIRGRTQKVLDGLPRG
ETFNFVDRVSIELTTQMLATLFDFPFDERRKLTRWSDVATALPKSGVVDSEQQRRDEL
NECAAYFARMWNDRVNSEPRNDLLSMMAHHDATRTMDRDNLIGNILLLIVGGNDTTRN
TMSGSVLALNENPHEFEKLRANPKLIDTLVPEVIRWQTPLAHMRRTALQDAELGGKTI
RKGDRVVMWYVSGNRDDEVIERPEEFIIDRARARIHLSFGFGIHRCVGMRLAELQLRI
VWEEMLKRFERIEVVGEPKRVYSSFVKGYESLPVRVS

CYP153A6 Mycobacterium sp. HXN1500

MTEMTVAASDATNAAYGMALEDIDVSNPVLFRDNTWHPYFKRLREEDPVHYCKSSMFGPYWSVTKYRDIMAVETNPKVFS
SEAKSGGITIMDDNAAASLPMFIAMDPPKHDVQRKTVSPIVAPENLATMESVIRQRTADLLDGLPINEEFDWVHRVSIEL
TTKMLATLFDFPWDDRAKLTRWSDVTTALPGGGIIDSEEQRMAELMECATYFTELWNQRVNAEPKNDLISMMAHSESTRH
MAPEEYLGNIVLLIVGGNDTTRNSMTGGVLALNEFPDEYRKLSANPALISSMVSEIIRWQTPLSHMRRTALEDIEFGGKH
IRQGDKVVMWYVSGNRDPEAIDNPDTFIIDRAKPRQHLSFGFGIHRCVGNRLAELQLNILWEEILKRWPDPLQIQVLQEP
TRVLSPFVKGYESLPVRINA

CYP153A7 Sphingomonas sp. HXN200

MEHTGQSAAATMPLDSIDVSIPELFYNDSVGEYFKRLRKDDPVHYCADSAFGPYWSITKYNDIMHVDTNHDIFSSDAGYG
GIIIDDGIQKGGDGGLDLPNFIAMDRPRHDEQRKAVSPIVAPANLAALEGTIRERVSKTLDGLPVGEEFDWVDRVSIEIT
TQMLATLFDFPFEERRKLTRWSDVTTAAPGGGVVESWDQRKTELLECAAYFQVLWNERVNKDPGNDLISMLAHSPATRNM
TPEEYLGNVLLLIVGGNDTTRNSMTGGVLALHKNPDQFAKLKANPALVETMVPEIIRWQTPLAHMRRTAIADSELGGKTI
RKGDKVVMWYYSGNRDDEVIDRPEEFIIDRPRPRQHLSFGFGIHRCVGNRLAEMQLRILWEEILTRFSRIEVMAEPERVR
SNFVRGYAKMMVRVHA

CYP153A8 Sphingomonas sp. HXN200

MDTDMVEPNIREKVAFIPIDEIDVARPSLFQKDTVGLFFERLRREEPVHYCRESYVGPYWSITKFDDIMAVDTNHKVFSS
EAKLGGIAIEDMHSAKSALELEMFIAMDPPKHNQQRKAVTGAVAPSNLLLLEPTIRERACQILDDLPVGEDIDWVDKVAV
ELTTMTLATLFDFPWEERRKLTRWSDVTTAAPETGIVASYEARRAELIECAMYFKGLWEQRINAEPKNDLISMMAHSPAT
RDMPFLEFLGNLLLLIVGGNDTTRNSISGGVLALNQNPDAYLKLNNDPGLITSMVPEIIRWQTPLTHMRRTALQDWEIGG
KKIRKGDKVVMWYLSGNRDETVIDRADEFIIDRKNPRHHLSFGYGIHRCMGNRLAELQLRIIWEEIHKRFAKIEVTGEPE
RLFSNLVRGITKLPVRLHAR

CYP153A9 Bradyrhizobium japonicum USDA 110

1 MNRRLEIHRA DDGYIIPLSE LDVSEGKRFQ DDSIWGCFER LRREDPVHYC QNSAHGPYWS
61 ITKYRDIVAV DTNHHAFSSQ QGVTIVEVPD KHWTPSFIKM GPPQHAEQRN TVSPIVGPES
121 LTRLETLIRS RVRMILDGLP RNEVFNWVTK VSIELTTQTL ATLFDFPFED RRLLTYWSDA
181 AVTTPKAGYA IDSWDKRSTI LSECLDYFTR LWNERINAEP RLDLISLMAH SPVTRHMEPT
241 EFLGNLILLI VGGNDTTRNS ITGGLLFMSQ YPSELRKLTD NPKLISSAVS EIIRYQTPIA
301 HMRRTAAIDS IVGGKPIRTG DKVVMWYISG NRDEEVIENA NSFVIDRKNV RQHLSFGFGI
361 HRCLGRHLAE LQLRVLWEEI LDGGLKIKVV GEPERIASNF VHGYSALPVR IEA

CYP153A10 Burkholderia fungorum

MRHVSCLRRSRLERSRGRARRPGGFHADLFTDPQGQLAALLPDR
GARGTRRTGPAPSRRPALTTLARHSNPVPDKALAPLTRNCHSAKVNCMNTLVVDSSHV
RLAPDALSQPVEDIDPSLPYRFQQQTHFAMFDRLRRESPVHYVKDSEYGPFWSVHRYN
DIIDVEIDHATFSSDVKYGGMLIKDLPENMRRTSFINADPPLHDHQRRVVSPIVAPGN
LNRLEHTIRREAADILDGLPRGETFDWVDNVSIELTGRVLCELMDFPRADRRLLTYWS
DIVNVDLEVGGEINTEEKRYVKLKECASYFGVLFKERMNSEPKDDLISMLAHSEYTKN
MPEQEFLGMIVLLMVGGNDTTRNSISGGLVALNQFPEQYAKLHNDPGLIPKLVPEILR
WVTPVTHMRRTATRDIEFRGKQIRQGDKVVVWYASGNRDSDVIKDPYQFIIDRANPRL
HLSFGFGIHRCLGNRLAELQLRVLWEEILKRQMLIEMMGEPVRKYANNITGVMALPVRIAA

CYP153A11 Sphingomonas sp. HXN200

MQSGPDREEPDRPIAEIPLAEIDVSRPSLFQSDKVGAFFERLRREDPVHYCSESAFGPYWSITRYNDIMAVDTNHKLFSS
EAKLGGIAIQDMHNDATNLELEMFIAMDQPKHDAQRKAVTPAVAPSNLLLLEPVIRERAGAILDSLPVGEEIDWVKSVSV
ELTTMTLATLFDFPWDERAKLTRWSDVTTAIPGSGIVESNEQRRQELIECAMYFKGLWDQRIDRSEGSDLITMMANSPAT
REMPFLEFLGNLLLLIVGGNDTTRNSISGGVIALNQNPDQYEKLRQHPSLIGSMVPEIIRWQTPLTHMRRTALADSEIGG
KRIRKGDKVVMWYLSGNRDETVIERPEEFIIDRKNPRQHLSFGYGIHRCMGNRLAELQ

CYP153A12 Alcanivorax borkumensis

MSTSSSTSNDIQAKVINATSKVVPMHLQIKALKNLMKVKRKTIGTSRPQVHFVETDLPDVNDVAIEDIDTSNPFLYRQSK
SNSYFKRLRDEAPVHYQKDSAFGPFWSITRYEDIVFVDKNHELFSSEPQITLGEFPEGLSVEMFIAMDPPKHDVQRRAVQ
GVVAPKNLKEMEGLIRKRTGDVLDSLPLDTPFNWVPVVSKELTGRMLASLLDFPYDEREKLVGWSDRLSGASSATGGEFT
NEDVFFDDAADMAWSFSKLWRDKEARQKAGEEPGFDLISMLQSNDDTKDLINRPLEFIGNLALLIVGGNDTTRNSMSGGV
LAFNQFPEQFEKLKANPKLIPNMVSEIIRWQTPLPHMRRVATQDVELNGQTIKKGDRVLMWYASGNQDERKFENPEQFII
DRKEARNHVAFGYGVHRCMGNRLAELQLRILWEEILPRFEKLEVIGEPERVQSNFVRGYSKMVVKLTAKK

CYP153A13 Alcanivorax borkumensis Strain AP1

MSTSSSTSNDIQAKVINATSKVVPMHLQIKALKNLMKVKRKTIGTSRPQVHFVETDLPDVNDLAIEDIDTSNPFLYRQGK
ANAYFKRLRDEAPVHYQKNSAFGPFWSVTRYEDIVFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRRAVQ
GVVAPKNLKEMEGLIRKRTGDVLDSLPLDTPFNWVPVVSKELTGRMLASLLDFPYDEREKLVGWSDRLSGASSATGGEFT
NEDVFFDDAADMAWAFSKLWRDKEARQKAGEEPGFDLISMLQSNEDTKDLINRPLEFIGNLALLIVGGNDTTRNSMSGGV
LALNQFPEQFEKLKANPKLIPNMVSEIIRWQTPLAYMRRVAKQDVELNGETIKKGDRVLMWYASGNQDERKFENPEQFII
DRKDTRNHVSFGYGVHRCMGNRLAELQLRILWEELLPRFENIEVIGEPERVQSNFVRGYSKMMVKLTAKK

CYP153A13a Alcanivorax borkumensis Strain SK2

MSTSSSTSNDIQAKIINATSKVVPMHLQIKALKNLMKVKRKTIGTSRPQVHFVETDLPDVNDLAIEDIDTSNPFLYRQGK
ANAYFKRLRDEAPVHYQKNSAFGPFWSVTRYEDIVFVDKSHDLFSAEPQIILGDPPEGLSVEMFIAMDPPKHDVQRRAVQ
GVVAPKNLKEMEGLIRKRTGDVLDSLPLDTPFNWVPVVSKELTGRMLASLLDFPYDEREKLVGWSDRLSGASSATGGEFT
NEDVFFDDAADMAWAFSKLWRDKEARQKAGEEPGFDLISMLQSNEDTKDLINRPLEFIGNLALLIVGGNDTTRNSMSGGV
LALNQFPEQFEKLKANPKLIPNMVSEIIRWQTPLAYMRRVAKQDVELNGQTIKKGDRVLMWYASGNQDERKFENPEQFII
DRKDTRNHVSFGYGVHRCMGNRLAELQLRILWEELLPRFENIEVIGEPERVQSNFVRGYSKMMVKLTAKK

CYP153A13b Alcanivorax borkumensis Strain SK2

No accession number
Jan van Beilen
Submitted to nomenclature committee 7/21/2004
Nearly identical to CYP153A13 from strain AP1
Two genes in this strain code for identical proteins

CYP153A14 Mycobacterium marinum

MDRIIQGAHLYDRTRRWVTGTNGEKIFIERPIPPADEVELTDIDLSNPFLYRQGRWKSYYERLRNEAPVHYQAHSAFGPF
WSVTRHADIVAVDKNHEVFSSEPFIVIGSPPRFLDIAMFIAMDPPKHDRQRQAVQGVVAPKNLREMEGLIRERVVDVLDA
LPLGEPFNWVQHVSIELTARMLATLLDFPFEQRRKLVQWSDLATSMEQANGGPSDNDEIFRGMVDMARGLSAHWRDKAAR
TAAGELPGFDLITMLQSDESTKDLIDRPMEFLGNLVLLIVGGNDTTRNSMSGGVLALNEFPDQFEKLKANPELIPNMVSE
IIRWQTPLAHMRRIAKADTVLNGQFIRKGDKVLMWYASGNRDERVFDRPDDLIIDRANARNHISFGFGVHRCMGNRLAEM
QLRILWEELLPRFENIEVVGEPEYVQSNFVRGISKLMVRLTPKGGA

CYP153A15 Hyphomonas neptunium

859136 MAADTVSFVNHPALERPKVTEREPLHPHNLRFGANIPPAADIDLSTLDLIDGELWRQGKY 858957
858956 WDRFERLRNEDPLHYCPDSFPGPFWSVTRYEDVMAIDTDHKRFSSSWEYGGITLGEPISD 858777
858776 FEMPMFIAMDEPRHSEQRKTVQPAVAPDMLKVYEPLIRSRTQGLLDSLPVNEPFDWVDKV 858597
858596 SVELTTMMLATLFDYPFENRRDLTHWSDVATGMHNPDICPGGEEEWKATMMKCLMTFMGI 858417
858416 YQERQQQPQKPDLMSLLAHGEKTKNMTPMELLGNVILLIVGGNDTTRNSMTASVFALNKF 858237
858236 PKEYEKLKADPSIIPNMVSETIRWQTPLAYMRRTALEDVEMHGKTIKKGDQVAMWYVSAN 858057
858056 RDERFWDKPNDFIADRPEARRHISFGFGIHRCVGNRLAELQLRILWEEIMERFEHIEVLA 857877
857876 EPSLNQNAFVKGYNWMPVVLHPK 857808

CYP153A16 Mycobacterium marinum MM3154

MSNIREAVTA KAQATIPMDR IIQGAHLYDR TRRWVTGTNG EKIFIERPIP PADEVELTDI
DLSNPFLYRQ GRWKSYYERL RNEAPVHYQA HSAFGPFWSV TRHADIVAVD KNHEVFSSEP
FIVIGSPPRF LDIAMFIAMD PPKHDRQRQA VQGVVAPKNL REMEGLIRER VVDVLDALPL
GEPFNWVQHV SIELTARMLA TLLDFPFEQR RKLVQWSDLA TSMEQANGGP SDNDEIFRGM
VDMARGLSAH WRDKAARTAA GELPGFDLIT MLQSDESTKD LIDRPMEFLG NLVLLIVGGN
DTTRNSMSGG VLALNEFPDQ FEKLKANPEL IPNMVSEIIR WQTPLAHMRR IAKADTVLNG
QFIRKGDKVL MWYASGNRDE RVFDRPDDLI IDRANARNHI SFGFGVHRCM GNRLAEMQLR
ILWEELLPRF ENIEVVGEPE YVQSNFVRGI SKLMVRLTPK GGA*

CYP153A17 Ectocarpus bacterium, 59% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050

1458016 MTQATAATPLTDEFNPAEVALRDIDLSDANHFFNQHHWK
1458133 LFERLRNEDPVHFFEHEEFGRFWSVTRHADIMSIDTNHQQFSSEPSIFLGNTNSDEDENF 1458312
1458313 NPATFIAMDPPKHDAQRNAVNPAVAPPALRDLEPLIRQRVSAVLDSLPIGETFNWVDLVS 1458492
1458493 IEITTQMLATLFDFPFEDRYMLTRWSDMTTANPETLAAMGLTIEDRRNAMYECLEIFG 1458666
1458667 GLYAERAQLPPANDFISLMAHNEDMKNLDPMNLLGNLVLLIVGGNDTTRNSMSGGVLAL 1458843
1458844 HENPAEFAKLKADPSIIPNMVSEIIRWQTPLAYMRRTANEDLEFRGKQIKQGDRIMMWYV 1459023
1459024 SGNRDERAIERPNEFLIDRENARRHLSFGFGIHRCMGNRVGEMQVRILWEEILKRFDRVE 1459203
1459204 VVGKPARTLSNFVMGFTELPVRLHPKK* 1459287

CYP153A18 Ectocarpus bacterium, 70% to seawater bacterial sequence CYP153A25 JCVI_PEP_1096681995831

2416172 MTTANQTSPNGAIDVNDIPLAELDVSQPHLFKNDTWRPWFARLRAEAPVHYLADSENG 2416345
2416346 PFWSVTSHDMTKAVDANHKVFSSEEGGIAIVDPQPLDGEQLMRDPSFISMDEPKHATQRK 2416525
2416526 AVSPAVAPKNLAELEPLIRERAADILDNLPVGETFNWVDRVSVELTARMLATLFDFPYER 2416705
2416706 RRDLIRWSDVATAVPKVTGEANDMGARRDALIECATTFYQLWQERAAQPPKFDFVSM 2416876
2416877 LAHGEATKHLSEDPLLMLGNIILLIVGGNDTTRNSISGGVVALNQYPEEYQKLRDTPAL 2417053
2417054 IPNMVAETVRWQTPVIHMRRTALEDVELGGKTIRKGDKVVMWYLSGNRDEAVFPDADRLI 2417233
2417234 IDRPNARQHVSFGFGVHRCMGNRLAEMQLRVLWEEIMKRFHTVEVVGEVERLSNNFI 2417404
2417405 RGIASVPVRLHPL* 2417446

CYP153A19 Ectocarpus bacterium, 59% to CYP153A8 Sphingomonas sp. HXN200

2455477 MSQAFTHTPTSDVELSSTTNIADPDIWSNYEY
2455381 FPIFEKMRAEEPVHYCAESTYGPYWSVTRYEDIMAVDTNHQVYSSEADFGGIVID 2455217
2455216 DRIAIDPETNYKSASFISMDQPKHDDQRKSVNGITNPNNLQYFGDIIRTRTVNMLDSLPV 2455037
2455036 GEEFDWVPTVSIELTTQMLATLFDFPFEDRHKLTRWSDVITAEPESDIVENQE 2454878
2454877 ARVAELNEMAEYFVELQKGRINKPDSIDLLTMMTHSPAMAKMPPEEFMGNLALLIVGGN 2454701
2454700 DTTRNSMSGSIFGMHLFPDEFKKMVDDPSLTDNAVAEIIRWQTPLSHMRRTALQDAVL 2454527
2454526 GGKQIRKGDKVVMWYASGNRDTSIFDDPDKIIIDRKNARRHLSFGFGIHRCMGNRIGELQ 2454347
2454346 LRILWEEILKRFSRVEVTGEPVLTHSNFVKGYASLPVKLHAL* 2454218

CYP153A20 Ectocarpus bacterium, 58% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050

2456749 MSQAFKHTPPATQPLTSKTNVADPALWESYSY
2456653 FPIFEQMRQEDPVHYCAESTYGPYWSVTRYEDIMAVDTNHHVYSSDAHLGGIIID 2456489
2456488 DGIQNDPENDFKAVNFIAMDKPKHDEQRKSVNGITNPNNLQHFGEIIRKRTSNLLDSLPV 2456309
2456308 GEEFDWVSTVSIELTTQMLATMFDFPFEDRHKLTRWSDVSTAEPGSGIVETQQQRI 2456141
2456140 DELMEMAAYFSDLQQSRKDKPDNIDLLTMMTHSPAMANMPPEEFLGNLSLLIVGGNDTT 2455964
2455963 RNSMTGGVFGFSLFPEQWDKMVADPTLIDNAVAEIIRWQTPLAHMRRTALEDAILGG 2455793
2455792 KQIRKGDKVVMWYASGNRDTSIFDDPDKIIIDRKNARRHLSFGFGIHRCMGNRIGELQLR 2455613
2455612 ILWEEVLKRFSRIEVTGEPELTNSNFVKGYTSLPVKLHAL* 2455490

CYP153A21 Ectocarpus bacterium, 68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050

2728336 MSQAAVQPEGEIDHTERAWSMPLKDINIADPDIFQADAIW
2728456 PYFERLRKEAPVHKAYSPDFGEYWSVTRYEDIMAVDTNHHVFSSSWEHGGITLFDQISDF 2728635
2728636 QLPMFIAMDPPKHDQQRITVQPIVAPNNLKNWEGLIRERTGQILDSLPRGEVFDWVDNVS 2728815
2728816 VELTTMMLATLFDFPFEQRRKLTRWSDVATGRNNPEIVADDDQWRAELLECLEAFT 2728983
2728984 DIWNERINSDTPGNDLITMLTRGESTKNMDPMEYLGNIILLIVGGNDTTRNSMTASVYA 2729160
2729161 LNKFAGEYDKLLAKPDLIPNLSSEIIRWQTPLAHMRRTALEDIVLNGAHIKKGDKVAMWY 2729340
2729341 VSGNRDESVFEDADKVIIDRPNARRQMSFGYGIHRCVGNRLGELQIKILWEEILKRFPKI 2729520
2729521 EVMEEPTRTKSVFVKGYTYMPVRIPA* 2729601

CYP153A22 Ectocarpus bacterium, 71% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050

2729680 MSQAAAETPSTVDHQERAWS
2729740 MPLEDINVADGALFQDDAIWPYFERLRKEAPVHKGHSDEFGDYWSVTRYEDIMAVDTNHH 2729919
2729920 VFSSEGAITLADPLEDFRAPMFIAMDPPKHDKQRITVQPIVAPKNLQNWEGLIRERTGLI 2730099
2730100 LDQLPRNETFDWVDKVSIELTTMMLATLFDFPFEERRRLTRWSDVATGRDNPEIYK 2730267
2730268 SEEQWRGELMECLEAFTGLWNDRVNSDTPGNDLISMLASGESTKNMDPMEYLGNIILLI 2730444
2730445 VGGNDTTRNSMTGSVYALNKFAGEYDKLIADPSLIPNLSSEIIRWQTPLAHMRRTALEDI 2730624
2730625 ELNGQMIKKGDKVAMWYVSGNRDTAVFENADDVIIDRPNARRQMSFGYGIHRCVGNRLGE 2730804
2730805 LQIKILWEELLKRFPKIEVMEEPTRTRSPFVKGYTYMPVRIPA* 2730936

CYP153A23 Ectocarpus bacterium, 68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050

2731016 MSQAVAEPQTDVDHAERAWS
2731076 MPLNEINPARRDLFQNDVIWPYFERLRKEAPVHKAYDEDFGEYWSVTRYEDIMAVDTNHH 2731255
2731256 VFSSDWTNGGITLFDAAEDFRLPMFIAMDPPKHDQQRITVQPIVAPNNLKNWEGLIRERT 2731435
2731436 AYVLDSLPRGETFDWVDNVSIELTTMMLATLFDFPFEERRKLTFWSDMVTTDPKT 2731600
2731601 LEGGVEEKRGHLLACLEYFTGLWNERINSDTPGNDLITMLTRGESTKNMDPMEYLGNI 2731774
2731775 ILLIVGGNDTTRNSMTASVYGLNKFPGEYDKLIADPSLIPNLSSEIIRWQTPLAHMRRTA 2731954
2731955 LEDIELNGTMIKKGDKVAMWYVSGNRDADVFENADDIIIDRPNARRQMSFGYGIHRCVGN 2732134
2732135 RLGELQIKILWEEILKRFPKIELMEEPTRTPGCFVKGYTYMPVRIPA* 2732278

CYP153A24 Ectocarpus bacterium, 68% to CYP153A2 Caulobacter crescentus CB15 GenPept AAK22050

2732360 MSQAVAEPHTEIDHTERAWS
2732420 MPLNEFNPAQRDLFQNDVIWPYFERLREEAPVHKCFDEEFGEYWSVSSYEHIMAVDTNHQ 2732599
2732600 VFSSSWEHGGITLFDGPEDFQLPMFIAMDQPKHDEQRKTVQPIVAPNNLKSWEPLIRERT 2732779
2732780 GMVLDSLPRGETFDWVDNVSIELTTMMLATLFDFPFEDRRKLTFWSDMVTTDAN 2732941
2732942 TLEGGEEEWKGHLLECLAYFTELWNQRINSDKPGNDLITMLTRGEATKNMDPMEYLGN 2733115
2733116 IILLIVGGNDTTRNSMTGSVYALNKFPTEYDKLIADPGLIPNLSSEIIRWQTPLAHMRRT 2733295
2733296 ALEDFELGGKMIKKGDKVAMWYVSGNRDKTVFENADDVIIDRANARRQMSFGYGIHRCVG 2733475
2733476 NRLGELQIMILWEEILKRFPKIELMAEPTRSPGCFVKGYTYMPVRIPE* 2733622

CYP153A25 JCVI_PEP_1096681995831 seawater sequencing, 70% to CYP153A18

MSIHPEIDNSSGPLRELDVSLPEHYENDTWRPMFARLRKEAPVHYLSDSVNGPFWSVTSHALIKEVDANNSIFSSEKGGI
SIVDLKPVEGQVQGKNFIAMDEPEHSIQRSAVAPSVAPKNLVELEPLIRERAVDILENLPVGETFNWVQEVSIELTARML
TTILDFPYDQRHKLVQWSDLATDVPQVTGKEGTDMQARYDELMNCAAAFYQLWVSKSGQPPSFDLISMLQNNPDTARMNE
DMELFLGNMLLLIVGGNDTTRNSISGGVMALNQYPDEYQKLRDNPALIPNMVSEIIRWQTPVIHMRRTALEDYELGGQHI
KKGEKVIMWYLSGNRDESVFEDPDRLIIDRPNARSHVAFGFGVHRCMGNRMAELQLRVLWEEIMERFHTIEVVGDITRLP
NNFIRGIKEVPVRVHAH*

CYP153A26 ABS61648.1 Parvibaculum lavamentivorans DS-1

CDS  27133..28401 locus_tag=”Plav_0025″
73% to CYP153A2 Caulobacter crescentus
MSDAAVKYEADEARDEAYSIPLAEINVADPSLFRDYKMWPYFERLRAEAPVHYSQGNEDTGPYWSVTRYN
DIMSVDTNHQVFSSEGGITLRDQDEDFKLPMFIAMDPPKHDDQRKVVSPIVAPGNLAKLEGTIRERAGKI
LDELPTGEPVDWVDRVSIELTTQMLATLFDFPFEERRKLTRWSDVATATEESGIIESEEQRRAELLECAE
YFMGLWNERVNAREPGNDLISMLAHGESTRNMDKMEYLGNLILLIVGGNDTTRNSISGGLYALNKFPDQY
KKLLANPGIIPNMVPEIIRWQTPLAYMRRTALQDAEVGGQTIRKGEKVAMWYVSGNRDESVIQNPNELVI
DRERPRQHLSFGFGIHRCVGNRLAEMQLRIIWEEILKRWDQPIRVLSEPQRVHSSFVKGYEKMMVELPKR
KH

CYP153A27 ABS63384.1 Parvibaculum lavamentivorans DS-1

CDS  complement(1917064..1918329) locus_tag=”Plav_1765″
68% to CYP153A2 Caulobacter crescentus
MSETLVAARDKSIADAYAIPLEKIDVSNPELFRANAIWPYFERLRREDPVHYCKESEYGSFWSVTKYKDI
MHVDTNHGIYSSEATLGGVALRNQEEGFFLPMFIMMDPPKHDAQRKVVSPIVAPGNLAKLEGTIRERAGN
ILDSLPVNETFDWVDRVSIELTTQMLATLFDFPWEERRKLTRWSDVAAAGTAFGDEETEKARRNELRDCA
AYFTELWNQRVNATEPGNDLITMLAQGEATKNMGPMEYLGNVLLLIVGGNDTTRNSITGGLLALNENPVQ
YKKLRDNPSLVESMVPEIIRWQTPLSHMRRTALQDTELGGKQIKKGDKVVMWYVSGNRDEEAIENANSFI
IDRKHPRQHLSFGFGIHRCVGNRLAEMQLRVVWEEILKRWPDKPIEVVGEPTRVFSNLIKGYSSMPVRIP
G

CYP153A28P Pseudogene (their call) Parvibaculum lavamentivorans DS-1

CDS 1927820..1929084 locus_tag=”Plav_1775″
67% to CYP153A2 Caulobacter crescentus
1927820 MSSMNVAERVQSLDDPYAIPLDKLNVSDPELFRSNRMWPYFERLRREDPVHYCAESAYGPFWSVTK  1928017
1928018 YKDIMHVETNHGVYSSDVEQ  1928077 (frameshift)
1928077 GGITIRDNNAGLKLP
1928122 MFIAMDPPKHDAQRKVVSPIVAPANLAKLEGTIRERAGKILDSLPVNETFNWVDRVSIEL 1928301
1928302 TTQMLATLFDFPWEERRKLTRWSDVATSEEAFKTPEGEAAREAELLECAAYFTELWNQRV 1928481
1928482 NATEPGGDLITMLAQGESTKNMSPAEYLGNVILLIVGGNDTTRNSLTGGLLALHE 1928646
1928647 NPDQYRKLRENPALVETMIPEIIRWQTPLTHMRRTALQDTELAGKRIKKGDRVVMWYVSG 1928826
1928827 NRDEEAIDEPNRFIIDRARPRQHLSFGFGIHRCVGNRLAEMQLRIVWEEILKRWPDKPIE 1929006
1929007 VVDEPKRVFSNFIKGYEALPVRIPG* 1929084

CYP153A29 Parvibaculum lavamentivorans DS-1 ABS63400, 73% to 153A8

CDS 1935500..1936753 locus_tag=”Plav_1782″
temporarily named CYP153A26 but revised to match genome order of P450 genes
1 MTTDTLVGDT ASTVPLSQMD VSDPKLFQSD MIGSYFARLR REDPVHYCPE SAYGPYWSVT
61 KFNDIMQVEV NHQTFSSEAK LGGIALQDMQ SGEAALELEM FIAMDPPKHD AQRKAVSPAV
121 APSNLVLLEP IIRERAGIIL DSLPIGEEID WVDRVSIELT TMTLATLFDF PWEERRKLTR
181 WSDVATSTPE TGVVSSFEQR REELLECAHY FKGLWDQRVN EPPKPDLISM MVHSPATRDM
241 PYLEFLGNLI LLIVGGNDTT RNSISGGVLA LNQNPAEYRK LMADPDLIPK MIPEIIRWQT
301 PLTHMRRTAL MDAEIGGKKI RKGDKVVMWY LSGNRDDEVI DRPNEFIINR PNSRHHLSFG
361 FGVHRCMGNR VAELQLRIIW EEILKRFSKV EVVGAPERTL SNFIRGFTHL PVKLYVH

CYP153A30 ABS63566.1 Parvibaculum lavamentivorans DS-1

CDS  2129237..2130550 locus_tag=”Plav_1951″
58% to CYP153A26 Parvibaculum lavamentivorans DS-1
54% to CYP153A2 Caulobacter crescentus
MSEQVSVGRDYTRSNADLAAKWKIDVNRDPWSIPLEELDPAHDELFAANTVLPYFERLRKEDPVHLNETG
PYGRYWSVTKYEDIMHVDTNHKIFSSDIRNGGIRLGGQRIEGEPDPLTYLPMFIMEDPPKHDEQRKAVQP
MFTPQNLADLEPLIRERAGLILDALPRGETFNWVRQVSVELTGRTLATLFNVPQEDRHKLIHWSDTVERL
GDPEYFETPEEGFKELWNCWEYFDGVWKDRLANPGSDLISLLAHSPSTKNMPPNEYLGNMLLLIVGGNDT
TRNSITGGVLALNQYPDEYAKLIANPDIIPNMVSEIIRWQSPVAHMCRTATEDTELGGKKIRKWDKVAMW
YVSGNRDDSKIDRANEFLIDREGARHHLSFGFGIHRCIGNRVGEMQLRILWEEIMKRFKKVEVVGDPKYL
RSNFIRGITELPVIVRE

CYP153A31 ABS63742.1 [Parvibaculum lavamentivorans DS-1]

CDS  complement(2309535..2310806) locus_tag=”Plav_2128″
64% to CYP153A2 Caulobacter crescentus
77% to CYP153A7 Sphingomonas sp. HXN200
MTATASAAAPAGIDDPYALSLDQIDVSKPELFERNAEGAYFARLRREDPVHFCADSAYGPYWSITKYKDI
MAVDTNHQVFSSEAGLGGIIIEDGIQKSSGEGSIDLPNFIAMDPPKHDGQRKAVSPIVAPANLANLEGTI
RERVGRVLDGLPVGEEFDWVPAVSIELTTQMLATLFDFPFEERSKLTRWSDVATAEPGSGIVDSWEQRTS
EIMECAECFQGLWNERMEKPGMDLVSMMAHSPATHDMTPQNYLGNVLLLIVGGNDTTRNSMTGGVLALHQ
NPAEFAKLKANHGLIDSMVSETIRWQTPLAHMRRTALADAEVGGKTIRKGDKVVMWYVSGNRDKDVIIQP
DDFIIDRERPRQHLSFGFGVHRCVGNRLAEMQLKILWEEILKRFSRIEVTSEPVRTRSNFVRGYASMPVR
LHA

CYP153C1 Novosphingobium aromaticivorans

MAATLAPDRAINPHDVSLNALYTEDRWREPFRWLRENMPVSYRA
ESPFGAYWSVVTHDLIQQVELDPGTYSSSWQRGNITIADSVNETEFPNFIAQDPPIHT
AQRKVIAPAFGPSQMVKLERLVRERTTQLLDGLPMGEEFDWVERVSIPLTLGMLLILF
DMPFDEWRDIKRWSDWASGVSEDSLNDAYRAEFVQQMGQMLMRFDRELEARRALPPSD
DLLSRMVHSDAMGHLTPPERIANIALLIVGGNDTTRNSMSGLIEALHRYPAELDKLRA
DPALSANAAQEIIRWQSPVTHMRRTLTRDAELGGQRLAEGDKIVMWYISGNRDENVFP
DAERFDVTRENARRHIGFGHGIHRCVGARLAEVQIAAVIEEIATRRLRITPQGAPTRL
ASPFLHGFTAMPVVMSRD

CYP153D1 Novosphingobium aromaticivorans

MATQLAPEVPQFTYHSSPTATEAFAAWLKDNPQAIPAHSHPWDV
SRSDIYVEDRWQPIFAEMRAKAPVNRVPDSPYGAYWNVASHKAIMHVESLPELFSSSW
QYGGITIGDPPEDVDPQKLAERQLPMFIAMDRPDHTGQRRTVAPAFTPAKMVEMEAEI
RRRTASVLDSLPWGERFDWVDKVSIELTTGMLAILFGFPWADRRLLTFWSDWAGDVEL
TLARELADTRFGFLGEMAHYFQRLWGARMQAPPSGDLISMMIHSEAMNHMSPQEFMGN
LVLLIVGGNDTTRNTMSGIVHALDKFPDQRELLERDASLIPNAVQECIRYVTPLAHMR
RTATADTELFGNQIKAGEKVILWYISANRDETVFENPDKLMVDRPNARRHLSFGHGIH
RCVGARLAELQLRILLEEMHERRMRVRVAGEVERVRANFVHGFRKLEVELEKR

CYP153D2 Sphingomonas sp. HXN200

MATVIRETPADLHPLDLSRADLWREDQWQEPMRQLRAESPIYYCEDSKFGPYWSVTTYKPIQHIEALPKIFSSSWEYGGI
TVAGDGIEHLKEGEIPMPMFIAMDPPQHTAQRRTVAPAFGPSEIERMRADTQARTAALIDTLPVGEAFDWVERLSIELTT
DMLAILFDFPWENRHNLTRWSDALGDIESFNTLEERQQRLATAFEMGAAFKELWDHKAKNPGKHDLISIMLQSDAMNHMS
HEEFMGNLILLIVGGNDTTRNSMSAYAYGLHCFPEERAKLEANHDPDLAVNAMHEIIRWQTPLAHMRRTALEDTELFGHQ
IRARDKIALWYASANRDESIFPDGDRIIVDRENARRHLAFGYGIHRCVGARVAELQLTTLISEMQKRRLRVNVLAEPERV
NASFVHVSPHAGRTRALLTAVTAGPISAR

CYP153D3 Sphingomonas sp. HXN200

MASTATLVRTASPIAPIDVSLPELYAEDRWQEPFRTLRAQAPIQYVPDSKFGPYWSVTTYKPIVYIEALPKLFSSSWQYG
GISIAFDSDKLLEHEVRQPMFIAMDPPQHTAQRRTVAPSFGPSEVAAMKAEVQLRTGALLDSLPVGDPFDWVQKVSIELT
TGMLARLFDFPWEERHNLTHWSDIGGDVELIRSPEGLVERNTKLLQMGMAFAALWQEKAQNPGKDLISVMLKSDAMNHMS
NEEFIGNLVLLIVGGNDTTRNSMSSYAYGLAQFPEERAKLEANPALIPNAVQELIRWQTPLAHMRRTVEEDTEIDGQLMK
KGDKVVLWYLSANRDETVFKDADRIIVGRENARRHLSFGYGIHRCVGARVAELQLVTLLEEMAKRRLRANVLAEPVRVPA
CFVHGYKSLQVELSHY

CYP153E1 Erwinia chrysanthemi strain 3937

MKMTKQLQDVFEDIDAVPLEKINPASRDRFINAAELPMFERLRREDPVHFTPESEFGPYW 4874499
4874498 SLTLWEDIRAVGNNYRDFTSTQNIDLKSIEEKIKLEAALQALGHERRKNVGFITMDPPEH 4874319
4874318 TKHRKAVTPAVGPSSLAQMEPIMRERAGIILDSLPIGEPFDWVDLVSKELTATVLATLLD 4874139
4874138 FPFEERRKLTFWSDLLMFEPGHGLVKSWEQKAEETVKCYQVFEALWEKRRNGPPSYDLIS 4873959
4873958 MLAHHPDTRDMTLEQFRGTIVLLIIGGNDTTRNTISSSLYLLDKYPEEFAKLKANPKLVM 4873779
4873778 PMISETLRFHPPVNFMSRVATRDVEIRGKNIKEGDRVVMWYTSGNRDASAIEDPDTFSID 4873599
4873598 RERARRHLSFGVGVHACIGSRVAEMQLTVIWEEILKRFSRIEVLEEPERSYSNFLHGFEN 4873419
4873418 LKVII 4873404

CYP154A1 Streptomyces coelicolor cosmid E6

MATQQPALVLDPTGADHHTEHRTLREGGPATWVDVLGVQAWSVS
DPVLLKQLLTSSDVSKDARAHWPAFGEVVGTWPLALWVAVENMFTAYGPNHRKLRRLV
APAFSARRVDAMRPAVEAMVTGLVDRLAELPAGEPVDLRQELAYPLPIAVIGHLMGVP
QDRRDGFRALVDGVFDTTLDQAEAQANTARLYEVLDQLIAAKRATPGDDMTSLLIAAR
DDEGDGDRLSPEELRDTLLLMISAGYETTVNVIDQAVHTLLTRPDQLALVRKGEVTWA
DVVEETLRHEPAVKHLPLRYAVTDIALPDGRTIARGEPILASYAAANRHPDWHEDADT
FDATRTVKEHLAFGHGVHFCLGAPLARMEVTLALESLFGRFPDLRLADPAEELPPVPS
LISNGHQRLPVLLHAG

CYP154A2 Streptomyces avermitilis

MSEQQIIVLDPTGSDPDAEHQALRERGSAALVDILGVRAWSVSD
PALLKQLLTSKDVSKDGRAHWPAFAETVPTWPLALWVAVENMFTAYGDNHSRLRRMVA
PALSARRTAALQADIEALVNSMLDGLDAFPAGEVADLRKHLAYPLPIAVIGKLMGVPA
DRRTEFRTVVDNVFATHLSAEEQAANTAALYALLDALIEIRRAEPGQDMTSLLIAARD
EEDGSAFSDAELRDTLLLMISAGYETTVNVIDQAITTLLTDPCQLAHVREGRCTWQDV
VEETLRHQPAVKHLPLRYARIDIPLPDGQTIKTGEAILASYAAANRHPTWHEDADRFD
ATRPSKEHLAFGHGVHFCLGAPLARLEVATALRLLFERFPDARLATERTALEALPSLI
SNGHTSVPVHLRPTSSASS

CYP154A3 Streptomyces peucetius

MFTAYGGDHRRLRRMVAPAFSARRIQAMRSAVEKVVTALLDDLDSKPAGEAVDLRKHLAY
PLPIEVIGQLMGVPHEQRDGFRAEVDGVFDTTLTTEQASANTAALYEALNQLIVAKRAEP
GDDMTSLLIASRDDEGDGSALTDDELRDTLLLMISAGYETTVNVIDQAVTALLTDPEQLA
HLQSGRADWSSVVEETLRHEPAVKHLPLRYALTDIPLPDGQTIAQGEAILASYAAANRHR
DWHGESADRFDLTRPTKEHLAFGHGVHFCLGAPLARLEVATALQQLFERFPEIELAVPAE
ELKPLPSLISNGHQALPVRLRPAAR*

CYP154A4 Streptomyces scabies SCAB20211

MIDPTGRDIH GEAARIRERG PATRVLLPGP HDVEAWAVSS PDLLKRLLTD PRVSKDARQH
WPRLAAGEIT PEWPLFTWVA VQNMFTAYGG DHRRLRILVS KALTARRTAA LRPRIEEITE
ELLDRVEEGL GHGGTVDLRK EFCYPLPIQV ISELFGLPEE KGLVLKDLVD KLFDTSAEPG
EMTAAYERMY GVLGELVADK RESPGDDLTS GLIAARDEDD TRLSEQELLD TLVLVVSAGH
ETTVNLLDRA VHSLLTHPGQ LAHVREGRAT WDDVIEETLR VEAPVANLPL RYAVEDLDLG
EFGGPAGVVI AKGDPILAAY AAAGRDPGRH GKDADVFDVT RADKEHLAFG HGVHHCLGAP
LGRMEARIAL PALFARFPDL ELAAPEAELG HVESFISNGH RRLPVRRS

CYP154A5 SBI_1147 Streptomyces bingchengensis

58% to CYP154A4 Streptomyces scabies SCAB20211
missing about 34 aa at N-term
VAWAITDPTLLKQLVTDARVSKDPRQHWPKFINGEIPATWPLIAWVAVEN
MFTAYGADHTRLRRLVAKAFTGRRTTALRPRIEHLVSRFLDGLAAGGPDT
AVDLKAAYCHPIPMEVICELLGVPEGEMRERELEFVSTMFRTNAPPEEAI
AAYQGHEALLRELVTLKRHSPGDDITSDLIAVRDEDGSHLNEQELADTVG
VLIAGGFETTVQLLDNAVHAMLTHPDQLALVRSGQASWDDVIEETLRAQP
PVVNVPLRYAVEDIELEGVTIKQGDAIILSLTAVNRHPEVHGEDSDHFDI
TRAVKEHLAFGHGVHYCLGAPLARLEARIALPALFDRFPELQLAVPAQDL
LPLPTLISNGHQTLPVRTGR

CYP154B1 Streptomyces fradiae tylosin-biosynt.

MAPDPVLVPRVGTYSMRPTERSARMETTSCPYALDPLGRDLAGE
AAMLRSQGPATWVELPGGVGAWAVTGHRYVKQVVADPRVSREARHWPAFTEGRITEEW
PLYYWVAAQNMMFSYGERHARLRRMVAGAFTVRRTEALRPRIEGLVGELLDGLAASPA
GEPVDLRASFAKLLPMRVICALFGVPEADRDTLCAEVDTTFNTAATPEETTASQIKVF
RMLAELIALKRAEPEDDLTSALIAIRDSGDRLTEDELIGTLNLMIAAGAESTVHLIGN
AVAALLTRNDQRDLVRSGRAGWEDVIAETMRTKNPAAYLPLRYAVEDIDLDGVPIRKG
DPILVSFAAPGLDPERHGDDAAEFDLLRAGRDNLGFGHGVHYCLGAPLARLEAGIALE
KLFERFPAMSLARPVESLEPLSSLIVNGYAALPVLLGPAAS”

CYP154B2 Streptomyces avermitilis

MAETAEAPGTAEAPGTAEAPGTAEAPETAEVSGTAEAPRTAETA
EAPETNGTNRVAEGVGAAGVTGMNQCPYALDVTGRDLAGETAQLRTRGPAVEVELPGG
VAAWAVVRQKYVKQLLMDARVSKDARQHWPAFVSGQIDEAWPLYPWVANENMLFAHGD
RHARLRRLNAAAFTARRTEALRPRVEEITAALLDGLADRPAGEQVDLRAEFAKLLPMR
VICELFGIAEANREPLCTALELVFGTAVPADEMAAAQVKVFGMLAELVAEKRERPGGD
LTSALIEARDGDDSRLTEQELLGTLYLMIAAGQETTCTLITNAVAALCAHPDQLSHVR
EGRADWADVVGETLRTHGPAAYSPMRFAIDDIELDGVHIKKGDPILVSFAAAAADPEP
YGADAAVFDVLRPGRRDDLAFGYGVHRCLGAPLARLEATTALSALFTRFPDLTSVQPT
EELEPVRSFIVNGYGSLPVVLRPH

CYP154C1 Streptomyces coelicolor cosmid 6D11

MTTGTEEARIPLDPFVTDLDGESARLRAAGPLAAVELPGGVPVW
AVTHHAEAKALLTDPRLVKDINVWGAWRRGEIPADWPLIGLANPGRSMLTVDGAEHRR
LRTLVAQALTVRRVEHMRGRITELTDRLLDELPADGGVVDLKAAFAYPLPMYVVADLM
GIEEARLPRLKVLFEKFFSTQTPPEEVVATLTELASIMTDTVAAKRAAPGDDLTSALI
QASENGDHLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEAEWS
AVVEETLRFSTPTSHVLIRFAAEDVPVGDRVIPAGDALIVSYGALGRDERAHGPTADR
FDLTRTSGNRHISFGHGPHVCPGAALSRMEAGVALPALYARFPHLDLAVPAAELRNKP
VVTQNDLFELPVRLA

CYP154C2 Streptomyces avermitilis

MTTRIALDPFVSDLEAESAALRAAGPLAAVELPGGVPVWAVTHH
AEAKKLLTDPRLVKDINVWGAWQRGEIAPDWPLIGLANPGRSMLTVDGADHRRMRTLV
AQALTPRRVEQMRERITKLTEELLDRLTGEVVDLKADFAYPLPMYVVADLMGIDEARL
PRLGELFEKFFSTQTPPAEVIATLTELAGIMAETVAAKRAAPGDDLTSALILASEDGD
HLTDAEIVSTLQLMVAAGHETTISLIVNAVVNLSTHPEQRALVLSGEADWSSVVEETL
RYSTPTSHVLIRFATEDVPVGDKVLPAGDALIVSYGALGRDEAAHGPTAGEFDITRST
ENRHISFGHGPHVCPGAALSRLEAGVALPALYARFPKLDLAVPAAELRNKPVVTQNDL
FELPVRLG

CYP154C3 SGR1085 Streptomyces griseus

MNCPHTAAAQTDPGAGTVVIDPMVQDLDGETARLRDAGVLARIDLLGVPAWTVTRHAEARQLLLDQRLVKDIDAWGLWQSGVVTRAWPLIGMIDAGRSMFTVDGAEHRRLRTKTSQALTPRRLEAIRPEIEKFTDELLDALDAARGEDGVVDLKSVFAQPLPMKVVGMLMGVDE
SQHAMLTRQYKAFFSMLTPQEERLALLAELDVFYTDLVREKTARPTDDLTSALILAEEGGEPLTEEEVVGNLKAMVAAGHETTIGLVLNAVRALLSHPDQLRMVLAGEAGWDAVIEETLRWDTPTTHLLMRFATEDITVGDDVIRKGEGVVVSYRAIGRDVGHHGPDADAFDITRPT
RNRHMTFGHGPHICPGAALSRVEAGIALPALFTRFPGLRLAVPDEEITKLPVMTQNDMTAFPVLLG

CYP154C4 SGR3108 Streptomyces griseus

MTRIALDPFVRDLDGESAALRAAGPLAEVELPGGVHVYAVTRHAEARALLTDSRVVKDINVWNAWQRGEIPMDWPLIGLANPGRSMLTVDGADHRRLRTLVAQALTVKRVERLRAGIEALTNASLDRLAAHPAGAPVDLKAEFAYPLPMNVISELMGVDAADHPRLKELFEKFFS
TQTPPEEVPQMMADLGTLFTKIVDSKRANPGDDLTSALIAASEDGDHLTDEEIVNTLQLIIAAGHETTISLIVNVVEALATHPEQREKVLNGEIGWDGVIEETLRWNTPTSHVLIRFATEDIKVGDRVLPKGEGLIVSFGALGRDEEQYGPTAGDFDAGRTPNRHIAFGHGPHVCPGAALS
RLEAGIALPALYERFPELDLAVPAAELRNKPIVTQNDLHELPVKLGCPFGHDA

CYP154D1 Streptomyces avermitilis

MRGVPRAGRLVRRTAPTRRRSQETSLDTSSGTQPHRMDPAGGCP
HADNARLLARGAVAPVLLPGDIEGMAVLGHDALKEFLAHPEVAKNARHFTALQEGRTA
PGWPLLTFATVQGMTTADGEDHRRLRSLVSKAFTARRVERLRPWIEELTSALLDGLGR
AAEEGGQVADLRAHFALPLPMGVIGELLGVDAEHRDRLHHLSNQVVATDIGPEQAIAA
NRELVAVLSTVAAARAERPGDDLTSALIAARDEGGDRLSQQELIGTLVLMIIAGHETT
LNLITNAVRALCGNRDQLELVRKGDAGWPDVVEETLRWDAPVSYFPFRYPVRDLTVDG
TVIPAGTPVLAGYSAAGRDPAAHGPDADRFDVTRPARSETTRHLSLGHGAHYCLGAPL
ARMEATIALERLFTRFPDLELAVPEAELARHSSFVGNSVRALPVRPGVPRS

CYP154D2 SBI_870 Streptomyces bingchengensis

70% to CYP154D1 Streptomyces avermitilis
MTDATDETDATDATDATDGQCPVPHAAAPHAAQDPHRLDPTGAGQHAVNA
RLRERGAAVPVLLPGDVTAYAITRHEELKDFTTHPQVAKDACHFAALRDG
EIPPGWPLATFATVRGMTTADGADHKRLRSLVTRAFTPRRVETLRPAVEE
LTAALLDRLAEAAAEAPDGVVDLRRHFALPLPMGVICRLLGVGPEHQDRL
HALSNDIVGTRTAPERALAANREMIAILGQVAAARLRSPGDDLTSALIAA
HEEDGDRLSEEELIGTLVLMIIAGHETTLNLITNAVRALCAHRDQLELVR
SGVGEASWGDVVEETLRYDSPVSLFPFRYPTRDLTVGDTVIPQGAPVLVS
YTSAGRDPRAHGADADRFDITRHTRPDAARHLSFGHGAHYCLGAPLARME
ATIALDALFTRFPGLDLAVPDDALVPHPSFVGNSPQELPVRLRPAGPAAH
SG

CYP154E1 Thermobifida fusca

MGQSRRPHTVYLDPAKGVDIPAQRRELLDKGPVVRVAFPGNLEV
WALTHDAPLRNALADESVFVRGWRNWRALMAGEVDPTHPVANMLRVESMLARSGADHK
RMRGLVQAAFTRRRVEALRPRIEEITNELLDRMAESDGVVDLKAAYSFPLPIRVISEL
LGLNEEDHLTLQTLVTRTLSGTDPEANADAFTFVASLIEAKRKNLDDGLISAMIEARA
EDGDRLSETELIHNTLLLIIGGFETTMGMISNSVQLLLTHPDQLHLLRTGQASWENAI
EECLRFESAVVMLPFLYTTRDVEIDGITIPAGDAVLIGFGPANRDPQAYDDPDRFDIT
RPRPRHLAFGHGAHLCLGAALARLELLIALPALFERFPDITLVGEAPPTPTVFMNHPL
SRPVLLRPKP

CYP154F1 Thermobifida fusca

MAVSADHAAAGALPGARHPAGRRVRAGRRLLDHRLRSGTRRPGG
CPVHRPAQPVRDPRPPGVGDRAPRVPGAADLPADRGRRGECAAGPVAGRASRGSPRVA
GAAPFPVRPRTQGASCHLHPRRHHPTNGGT

MAAVPEPIVLVPGKSREQALQLREAGPL
ARVVVEGLEVWALTHDRELREALIDPRFRRNWRTWRALNEGEVATDHPVAAMVYLDNM
LTVDGEAHRRMRSPVAQAFTPRRVELLRPRVTEIVNALLDQLAERDGTVDFKTEFAYP
LSMRVFSALFGIPERDHGRMQQMVNTAFSPSSPEEVRAMREELDAFLDELIEDKRRSP
GEDLTSALVTATDEEHKLSDAELRDTLWLLVTAGFETTSSALANAVQTLLTHPDQLAH
LRSGSIAWEDAIEEVLRQSSSVATLPFLFAAEDVQIGDRTIRAGEPVLLAYLAANLDV
ERYGEDAAEFDATQSRPRHLAFGHGPHTCLGAALARLEMEVALTTLFTEFPEVSLAEG
EAPRLESVFIHAPAALPIRLGPRRTAA

CYP154G1 Thermobifida fusca

MLDTERGLTEADIHALAEHGPVVRLSVMGLDVWAVTGYEELRTL
MADPEVKRGVEHWTAVAQGKVPAEHPLVKLVSMGSMLSKNPPEHTRLRRLVQHAFTTR
RVEGLRPVVQELTRACLDRIDASQPFDINAALSHPVPVGVIGRLLGIPETDQPALDSL
VTRLLSGTDATVHEELYAYVAAMVAARREQPDDGLISALLHVHDDDGSTLSEEDLMWT
VVLLVDAGFETTVGQISNSVRLLLEHPDQLALVTSGEVPWERAVEECLRHTASVVMLP
FCFPTREKELGGYTIGAGEPVMMVYGAANRDSRVHAAPKVFDVTRSDSRHITFGHGPH
HCLGAPLARLELNVVLPELFARFPKLALAERDIPRVKSLFVNRPSELWVTAGMG

CYP154H1 Thermobifida fusca

MMASPTDNPIVLDPYVSDLEGERERLYEAGPIAWVELPGGVRTW
SVTHHQAARELLTDSRLSKNMAHWGAYNRGEISPTWPLLSVIPPTPTNLLGTDGAEHK
RLRTLTAQAFTPRRVEKLRPRIREITEELLDALEERANEPQDLKSEFSFKLPMRVIGE
LYGVEEAAHGQLRSLYDKFFSSVTPPEEFLATREALVQFYTELMERKKANPSDDLTTA
LLQANENGDRMTDEEVLGTLQIVVAAGHETTVNLLTNTVRALLRFPDQLELLRTGKAT
WEAAIEESLRWDPPTTNFIFRFATEDIEYGGVTIAKGDSVMISYGAIGRDRGQHGDNP
EVFDVTRKTSSRHISFGYGPHVCPGAPLARLEAQVALPMLFERYPDMKLAVDDSELVP
NPSVIVNSLKEFPVILRP

CYP154J1 Streptomyces carzinostaticus subsp. neocarzinostaticus

MCPYRLDPEGADTHGETARLREQGPIARVELQDGVLAWSVHDYA
VAKQIMADERFSKNPRKNWPAYINGEISNGWPLITWVAMDTMATQDGADHARLRKLLL
KAFTERRVESMRPHIEKTVKELLDNMAAKADDEIVDIKEMFHAELPTRLMCDLFGVPE
ERRAEVLAGGHKNIDTRISSEAAEANLGQWQEAISDLVEYKRHHPGDDLTSALIEARD
EGSRLSDSELIGTLHLLLGAGSETLVNALAHSSLALLVDADLRKKVTSGEIPWVNVWE
ETLRVESPVAHLPFRYATEDFEIGGVKISKGDPLLVDFAGIGRDPAVHSDAPDEFDAL
RPDKTHLSFGHGVHYCLGARLAKHAWMIGIPALFERFPDMELAVRRDELKGQGSFVVN
GHASLPVHLKGRAAALAR

CYP154K1 Streptomyces rochei plasmid pSLA2-L

MLRQEAPYVIDSAGRDLPGEAARLRERGPVVRVVLPGGVSAWAV
TDLDLIKQLLTDSRASKDAYRHWPAWAGGEVDESWQMSMWVSVRNMLTAYGEEHARLR
RLVAGAFTARRTADLRPRVERITARLLDGLAAVPPGAAVDVRNEFARPLSVLVMGETL
GLPEDLHADLQRMVDVLFKTTAEPEEARANQYELYALLTELVAARRSAPGTDLTSELI
AARDEDGGEGLSEKELVDTLLLLIGAGTETTVNLIDQAVHGLITHPAQLALVLGGEAT
WDSVIDETLRHQPVVANVPFRFAVEDIEVGGVTIPKGDPILLSLAAAARCPHRHGADA
DQFDVARPSRRDHVPFGYGVHHCVGRPLARLEVSIALESLFARYPRMAAAVPEAELAV
RESFISSGHVALPVVLVPGAAA

CYP154L1 Streptomyces scabies SCAB32131

MRVELPGGIP AWAITRHTVL RDLLLDDRVS KDPRHWELWT SGWVEANPEA HWIYNWTGVT
NMFTAYGPDH RRLRNLVAPA FTGRRTLDLL PRIEEITTSL LDSLSTRAAS LPGRPADLRI
LFAYPLPLLV ISELFGLTEQ ERGDAAHFVD MIMDTTTPPE IAGQILTHTR SVMARLLARK
REQPGNDLTS ALITARDQGD RLSEQELVDT LILTLGAGFE TTVNLIGNAI AALLDHPDQL
DLLLNGAVPW KQAIEEVLRW APPITSLPLR FATTTIDLGE ETIIQGEAIL TTFGAVGWDP
DTHGPRAHEF DITREPGKHL AFGHGVHHCL GAPLARAEAT IALPALFTRF PDLRLTMPAP
ELTPFPSFVS HGHTTLPAHL TPSPATSTAT

CYP154M1 Salinispora tropica (marine actinomycete)

MRRRCPVVIDPAGTDIHAEGARIRANGSVSQVELPGGVLAWSVTGQQVARKVLSDQRFSK
DPRKHWTDYLEGRIGQDFPLIGWVLMDNLTTAYGSDHSRLRKPCANAFTPRRVEALRPAV
ERAAVELLGELATVSPTESVDLKARYAHPLPSRVICDLFGVPEEDREEMLRGGEVNVDTR
VSAEEAAANVERWHQQMLDFIEEKRRNPGPDLTSDLIAAQQAEGSRLTDSEMVGTLHIML
ATGTEPVKNLIGNAVFALLTHPEQLDLVRSGRAGWDDVIQETLRMQAPVAHLPFRFAVED
VDIDGVTIRRGDPLLVNFAAIGRDPDVHGDTAAEFDITRADKEHLSFGHGVYRCIGQPLA
LREAEIALRMLFQRFPNLVLAVPPEEVTPQPTFIMNGLDTLPVLLKGRA

CYP154M2 SGR622 Streptomyces griseus

MVVESRCPVVIDRTGQNIHAEADRLREQGPVARVELPGGVRAWSVTGYDVALSVLGDQRFSKDPRKHWTAYANGEIGDDFPLIGWVLMDNLTTAHGSDHSRLRRLTAKAFTPRRVSAMRSAIEQACTELLDELAESGPGDKVDLKARFAHPLPARVICDLVGVAPQDRAAMLRGG
EVNVDTTTSPEDAAANVERWHQEMHEFVESKRRTPGDDLTSDLIAAQEEDGSRLSPSELVGTLHLMLGTGTEPVMNLIANAVHLLLTHPEQRAELRAGRISWDDVIEETLRAEAPVAHLPFRFPTEDVEIGGVTIPRGDPVLIAFAAAGRDPAVHGPSAGRFDPSRADKAHLAFGHGIY
RCIGMPLAREEARIVLPALFTRFPDLDLAVAPEDIEPQGSFIMNGLRTLPVRLRSEGAGR

CYP154N1 Frankia alni ACN14a

MVHVQPLSVAAAGPSLVAEAAALRARGPVAEVTLPGGIPAYAVNEHALLRALLLDPRVSKDPRRHWAQWD
EACRRPEWGWVLQWVGVVNMLSTYGVDHARLRRLVAPSFSARRTELLRPAVVAVTERLLDDLAAGSARAA
GSAGSVGSVGSVGSAGSVGSAGSVGSARSVGSAGSAGSVVDLVGTFAQPLPLAVISGLFGIPDRMRPDFA
HVVEQIMNTTVSSEQAAANLGRTRSVLATLVERKVREPGDDLTSELIGVRDAVTGDRLAHRELLDTLLLL
ISAGHETTRHLLGNAVHALLTHDRQLRRLRAGEITWDQVVEETLRWAPSIANIPLRFAVTDIDTGAVTIP
AGAAIVAGILAAGHDPGHHGPGASRFEPGRDAADHLAFGVGVHRCLGAPLARLEAGYALPALFARFPGLA
LATPADDLPQAPSFIVHGWQALPVRLAPPAPLVTASAR

CYP154P1 SBI_1935 Streptomyces bingchengensis

43% to CYP154D1 Streptomyces avermitilis
41% to CYP154H1 Thermobifida fusca
MDAISPVHLAPEPTDLHSVEGAALRAAGPVATVALPGGVVVKAVTTREAG
AQVLNDPRFSKSLRHWGAHQRGEIPAEWPLLFILEGEGLLNSDGDLHRRL
RQPVQRAFSPRRVRELRPRIEAVTDRLLAALDDVAPGQETDLQSRFALPL
PLDVICYLLGVPEEGGLREELHVLSAAALSNDAGAEELQRTMAERFPATL
MSIIERKRASGDHDDLTMDLVEAMDQGELTVPEVIGNLVVTVIGGHETTV
TLICHAVRGLLTHPETLAAARARQEAGEDPWPDVVEEALRWESPVRALLF
RYATEDVPVVGGGVVREGEAVLLPLATINRCPHAFSEPDRFDPDRPDASR
HLSFGYGAHRCPGASLAKVEAEIALRRLFETFPDIALAQRPAPRAASLGM
NSYRELPVVLRPATV

CYP155A1 Streptomyces coelicolor cosmid 6D11

DPGDHVVEPGGRRGRTAGVGGGHVVQDGRVSARKADRGRAGPAC
PVDRAADGTWRVHDFAVARALLRGPGTVQAGLGIETVEKLPPRVRRPVLYRDGPEHRE
HRRQTARYFTPRRVDEHYREPMVRIAEEQLAVLRSAGEAPLSDLAFGLAVGVVSEVVG
LRYSRPGIRRRLERFFPEEFGEPGLTSVRGLYWLVRQNTNWLRIHLADVRPAVRAHRR
REHDDLISHLIAEGCSDVEILGECLTFAAAGMVTTREFVCLAAWHLFSDAELLGHYRS
ADETGRLAVLQELLRLEPVIGSLRRRATGPVELSCRDGPVTVRPGEYVEVHLDDANAD
PKAVGEEPLLVRPERAGAVGAGLSFGDGPHRCPGAHIALLETDVFLSRLFALDGVRMS
GGPRVAFQEAIDGYEIRDLTVALPRAGRG

CYP155A2 Saccharopolyspora erythraea NRRL23338

MPTDSTDARKIDRGETEGGCPVHRRPDGVWEVRGYASARAVLRSTDTVQAGLGVETVEKM
PSRIRRPVLYRDGTEHREHRRQTARYFTPRRVDEHYRDIMERVTDEQLAKLRADGRAQLS
ELSFHLAIDVASSVIGLTESKPGIQARLERFFPEEFGEPGFTSINGIYWIFRQLRNWLGI
YLGDVRPAVRARKRRRQDDLISHLLDEGCSSAEILGECITFAAAGMVTTREFVNLAAWHL
FTDEALRERYRSAEEAERLEVLHELLRLEPVVGHLRRRTNAELRVPDGDSEVTVPAGEVV
DIVVSATNLDERVMGEQPASLCPGRELSDGAYAHGMSFGDGAHKCPGAHIAILETDTFLR
KLFALPGVTMETPPRVTFNDAIGGYELRDLVVSVSAN

CYP155A3 Frankia sp. CcI3

MADPVVTDVGTSARKIDREDPNGGCPVVQGADGVWRISGYAAGQAVLRSLETKQAGLGIDASKAIPKRIR
RPVLHSDGPEHRERRRLTARFFTLRRVDEHYRELMHRVADEQIDRLRRERSVDLSELSFALAVEVAAAVI
GLTNSRPGMAARLERFAQGDLGPPNVTSIRGIRQFIRQNRHALAFYLADVRPAVRARRRRRTDDLISHMI
DQGCTNAEIFAECVTFAPAGMITTREFINVAAWHLFTDDTLRARYHDADQTERIAILHEFLRLEPVISTL
KRRTTADIQLPGPHGPLTIPAGAQIDIAVSSTNIDTQAIGADPYTVRPARPIGDGVSPAGLSFGDGPHKC
PGAHVAIHETDIFLHKLFMLDGLHMASPPQVTLRDEIAAYELRGLVVTLD

CYP155A4 SBI_1967 Streptomyces bingchengensis

68% to CYP155A2 Saccharopolyspora erythraea NRRL23338
MGYGARKIERAADSDGRSGCPVRRGPDGVWQVCGYAEARAVLRSTDTVQA
GLGIETVEKLPSGLRRPVLYRDGPEHREHRRQTARFFTPRRVDERYREVM
VRVAEAQLGKVRAAGRAHLADLSFHLAIEVAASVIGLTESRPGIRRRLER
FFPEKFGTPGLTSLHGIHWLLRQNVNWLRVYLADVRPAVRARRGQRRDDL
ISHLLDEGCSAGEILGECLTFAAAGMVTTREFINVAAWHLFTDDALLGRY
RAADEPGRIAVLHEILRLEPVIGRLRRRTTAALELPGDDGVVTVPTGALV
DVDLESANVDARTVGERPELIRPGRPLAEGAGAVGLAFGAGPHKCPGAHI
AILETDIFLSRLFALPGIRMATPPGVGFKDEIGGYELRGCTVECRA

CYP155B1 Deinococcus radiodurans

MPSFLSFRSSAMTAHDAQPEPARCPFTGQAAPTETITRRHVPPQ
GDLAQPVETYARARDLLKSEQAQQAGFLADMVSRVPGSQHPPVLYLEGEEHTEMRRAT
AKYFTPTQVNTYQPDIARLADELIGKLARRGEAKLDDLSLELAVRVAAGVVGLTNSRL
PGMDRRIERFIPSGVDAEPGVKLEGASPLENARQAANMALFYALDVKPAIEARRKAPQ
DDLISYLLSRGYNDQDILTECVTYGTAGMITTREFISVAAWHLLKNPELRAAYVHGTE
KERHAVLHEILRLEPVVGTLYRRA
GTGDDCGRRSHPAGSVFALDIGQANLDPAVMGEGAEQLCPMRELPRGVQAQGLSFG
DGHHRCPGAFLAIKETDVFLRRLLIWNDLHVVSEPRVTYNEVIKGYELRGFRVRLGGARA*

CYP155B2P Deinococcus radiodurans

SGSTDAEILPYVVEAEPSSPVVHLDISQ
ANRDESVFTQAQQFCPHRKNVRQHLSFGKGEHACLGQSLVYTICRVMAHALELLSAPAGQ
RTDQVSQ*

CYP155C1 Brevibacterium linens strain ATCC 9175

MNSVSMRKAVGTHDETEPRVGHDGTMWRIRSYEAATTVLRARHQ
TTQAGFTAEKIPRGYFRQHPILISDGDDHDVQRREVARYFAPAVVSAKYGDFINKRAQ
ALVDSALANGRLRLDEAALNYSVEVTAEIVGLTDSPIDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWIQAAVNGLVPIGRFYISDVRPAIRARRDRRRDDVLSHLLSAGYSTADIL
VECVTYGTAGMVTTREFITMACWHLLTNDELGRRYTEASQPTRLEILEEIIRLDPVVG
HLYRRAQADIEVSDNGCPYTIPEGDLIDVCVRQTNTDPQAMGAAPETVIPGRDLRRGS
AATGLSFSDGAHTCPGQPLALYETDALLHKVLATRPRILREPTISWDNVIEGYRLRGL
DLSLMTRSRPVTTRMTT

CYP155C2 Brevibacterium linens strain ATCC 9174 (JGI genome

MNSAGMRKAVGAHDETEPRVEHDGAMWRIRSYEAATTVLRARHRTTQAGFTAEKIPRGYFRKHPILISDGDEHDSQRKEV
ARYFAPAVVSAKYGEFINERAQALVDRAVANGGLRLDEAALNYSVEVTAEIVGLTESSTDAMAKRLVGFFRQPPVDLAAP
AMGRTRRQWAQAAVNGLLPIGRFYVHDVQPAIRSRRSRRRDDVLSHLLSAGYSTADILVECMTYGTAGMVTTREFITMAC
WHLLTDEELGRRYTESSQPTRLKILEEIIRLDPVVGHLYRRAQADIEVSDNGCPHTISAGDLIDVCVRQTNTDPHAMGTA
PETIIPGRDLGRGTAATGLSFSDGAHACPGQPLALYETDALVHKLLTIGPRILRKPEISWDNLIEGYRLRGMDLSLMERS
RPAATREPI

CYP155D1 Frankia sp. EAN1pec

MTTTELPKCPMDPTRDDRKSAALAAQRVRADAGARVVGSFDFGRAILRSATMLQAGAGSEQVKVGGDEHG
PVFFLDGEEHRRRRTAIARFFTPKAISTRHRLVMERTSDELLARLRAKGGGQLDELSYQLAVAVAAEIVG
LTDSNQVAMARRIQATLLGTRLRGMHPVIRVGAQALTAVHAMRFFLRDVRPAIRSRRRERRDDVISHLID
EGYPDKAILIECMTYAVAGMVTTREFIVMVAWHLFDNDELRARFTAGGEADQTAIIEEILRLEPVAAMLH
RRATQDSDLGVGSVKEGELLAVSIRAANVDPETVGECPHALDPDRARRLKAVGSYMSFGDGSHRCPGAQV
AINETRVFLDRLMRLPDLRLARTPDMTWCDGLMSYELRGATVTCSRDLTPAAHEVGQDAGPDGEQT

CYP156A1 Streptomyces coelicolor cosmid E6 gene

MTLPSTETAPTGEPGRIALYAPEFAADPHAAYRSMRRTHGPLVP
VDLAPGVPATLVIGYYQARRILNDPLRFPADPRAWEKLIPATCPVRPMMEWRPNALRS
GGAEHTRYRSANTHAIDQVDQHGLRALVEQVASDAIEGFRTAGSADLLTQYSFPIAFR
VLSALLGCPDEIGQRIADGMAKIFDTTNADQGNLILAQAVSDLVTLRRTHPGDDITSR
LALHPVRLTDEEMSHQLVTLYGAGIEPMTNLISNTILKILTDEEFSADLHAGLSTVRD
ALDAVLYTDPPMANYCISYPPYPVDVEGVLLPADQPVVISMAAANNDPALTEGVPAGQ
HGGNRAHLAWSTGPHTCPARSHAYLIAETAVTHLLDALPETDLARPAAELVWRPGPFH
RALESLPVTFPAAQSAAH

CYP156B1 Streptomyces coelicolor cosmid IF3 gene

MDATTPAVPPPGCPAHADARIPLYGPDFAADPHAYYDYARSYGP
SAPVELAPGVDASLVTDYATALRLLQDNGTFRKDARRWKAFNEGLIPADSPVVPLLAY
RPNAMFSDGAEHLRLRQAITDAMARIDTARLARSTEQISDYLISQFGSRGSADLMADY
AKQLPLFVFNELFGCPADIGDRILFGISGMFDGVNAERAAEVLFGAVGELVALKRSRP
GEDVTSWLMQHETRMTDEEMVYQLSLILGAGADPLRNLIGNTLHRILIHDEYARQGGL
IDEAMEDTLWENPPVPNLAPHYPAADVEFAGQKFEAGELIMVSFAAANNSPSLAAARQ
SGSNRSHLAWSAGPHACPSKDPARQITMAAVENLLNRIPDIAAAVPEDSLTWRPGPFT
RGLTALPARFTPLPAPDRTPAPAQAPAGERAEQSGTARKAAGTGRWSQFLNWLTR

CYP156B2 Streptomyces scabies SCAB79211

MTPDSSFPAP PPGCPAHDSG MRVPLYGPEY AADPQAYYAY MRHYGQTAPV EIAPGVDATL
VTDHATALRL LQDSGNFRKD ARRWRDVAEG KIGPESPVVP MLGYRPNAMF TDGAEHARLR
QAITDSLAKV DSRRISDMTK RASDYLLAQV SARGSIDLMN DYVKQLPLLV FNELFGCPAD
IGDRVVFGIS GVFEGVNAEK ANAVLGQAVF ELVALKRARP ADDVTSYLMR HEARLTDEEL
VHQLILLLGA GAEPLRNLIG NTLHRLLLHD RYADGGLIEE AIDDTLWENP PMANFAPHYP
ALDLEFGGTK MRAGDLVLIS MTAANTDPAL ATARQTGGRR AHLSWSAGPH ACPSKELARL
VTMVSIENLL NRLHDIELAV PADSLTWRPG PFHRALAALP CRFTPQVLQR PTPPRAETAA
RGESAPAGRK QERGVWGSFL SWLKG

CYP156B5 SGR3494 Streptomyces griseus

59% to CYP156B4
MDPQPGATPYTAPAGCPMHQQRTALYGPEFAADPHRFYDAARTHGPAAPIELSPGVEATLIVQHEAALRVLQNPALFARDSRRWAALREGAVPMDSPVLPMMVYRPNCLFTDGAEHLRLRKAVTESLSRLNSSRLSRDVERIADYLIDQFIERGTADLLNEYAKLLPLLLFNQLFGCP
GDIGDRLTRSMSAIFDGEDVLRANAELTECLMELVALKRRQPGEDITSWLIQHPAGLRDEELKDQLVVLMGAGVEPERNLIANALLLMLAGEAPGAPERRGSGMLVEDALDDVLWNNPPIANYATHFPVQDIELDGVVLKAETPVLISFAAANSDPGLTDARQTLSKGAHLAWGAGP
HVCPAKSPATLIALTAIEKILNTVPDLALAVPASGVAWRPGPFHRALVALPVRFTPTAARRAATGAQPAAPVSAQLPDPFRNTPSAPSAAPRHAQEPAKKQKGWWSSFLDVFRV

CYP156C1 Streptomyces scabies SCAB20221

MTAPPPAGPP PGCPAHQPMY GPEFAADPAA FYRRARAHGP TAPVELAPGV RATLVTSYDA
ALYVLRGTET FAKDARRWRD LGDGTVPPDS PVVPMMMYRP NALFSDGEEH RRLRGAITDS
LARVEPHTLR GYVERSADTL IDRLAPTGGA DLLGEYAQVL PLLVFNHLFG CPAELGVKLV
EGMSAIFDGV DAERADALLT ATLVELVTLK RERPGPDVTS WLTLHPAKLT DEEMIHTLVV
LMGAGTEPQQ NLIANALRLL LSDDRFAGDL SGGSLPVEDA LDEVLWTDPP MANYAVHYPK
RDVLHEGALL RAGDPVVVSL AAANTDPALG TDQRTGNRAH LAWSAGPHNC PARSEARLIA
SVAVEKLLDR LPDIELAVPV EALEWRPGPF HRALAALPVT FPPAPALAAS APVAPEPPAA
SARPAPEPPV TPGPRPPEPA RPTSGRGRLL SWWRGERPGR A

CYP156C2P Saccharopolyspora erythraea NRRL23338

LINEFGSAGEADLLTQYAGPLTLRVLTWLFGCPTDLGQRLLADMAHIADAADAGAAGEAG
ADLDECLRRLVHLKRGHPGRGVTSRLMAHSAQLSDDEVVHQLVILMGVSGEAQQNLISNA
LRLLLSDERFAGDLSGGSLPVEDALDEVLWADPPIANHSTAYPTREVHLDGVHLPRVNRW

CYP156C3 SBI_1148 Streptomyces bingchengensis

57% to CYP156C1 Streptomyces scabies SCAB20221
VPTSTPDSGPTPPPGCPAHTGPGQAPGLPESLYGAEFAENPSAVYARLRA
YGPVAPVEISPGVHASLVTSYSTALEIMRNTETFPRDPRRWEALNNGTVP
MDSPVVPMMMYRPNPMYTDGEEHDRYRGAVSDTLNRLNPHALRTYVEESA
DLLIDLFGPEGEAELLSEYCARLPLLVFNQLFGCPPELSETMVKGMAALL
DASEDAVEANAVLIETLLALIALKRLEPGADITSWLLAHPARLNDEELVS
QLILLLGAGVEPVQNLICNALRLLLSDERFAGDLSGGTMPVDEALDEALW
TDPPIANYATHFPVRDVTIAGHRVGKGTPLLISMGAANNDPQLVSDRRGN
RAHLAFGAGPHACPAKDPARIIASTAVEKLLDRVPDIELAVDPAQLHWRP
GPFHRALAALPVHFPPVAAKYDQAGATATDQTTGGNAWTPSPAPSSSTPK
GATSTGREPGSGNGAQRPWWNSLITWWRGR

CYP156C4 SBI_1149 Streptomyces bingchengensis

59% to CYP156C1 Streptomyces scabies SCAB20221
80% to CYP156C3, 58% to CYP156C5
VPTSAPDSDPPPPPGCPAHSGQASEPGRPEPLYGPEFAADPAAVYARLRA
YGPVAPVELAPGVHASLATGYATALEILRSPDTFARDPRRWEALADGTVP
MDSPIVPLMMYRPTPMYTDGEDHERYRGAVSDTLNRLNPHTLRTYVEESA
DLLIDLFGPEGEAELLSEYCARLPLLVFNQLFGCPPELSETLVKGMAALF
DIDEDAMKADAVLREALSALITTKRAEPAADITSWLIAHPARLNDEEMTH
QLILLLGAGVEPVKNLIGNALRLLLSDDRFAGDLSGGTMPVDDALDEVLW
TDPPVANFCTHYPVHDVTVAGHRLAKGAPVLISMAAANNDPQLISDRRGN
RAHLSFGAGPHACPAKDPARIITSIAIEKLLDRLPDIELAVHPDQLRWRP
GPIHRALAALPVSFPPIAAKYDAVSAAATDQNPGGNAWNPSPAPSTSTRS
PSTPKDATSTERGRDSGNAAQRPWWNSLITWWRGR

CYP156C5 SBI_5524 Streptomyces bingchengensis

58% to CYP156C1 Streptomyces scabies SCAB20221
60% without insertion
VTYHPDATAAVGHSPDAEAGVGVAPPPGCPAHAGHAGFGGPARPAAQGLP
LYGPEFAADPHLFYERLRQYGPIAPVELSPGVEAYLITSYSLALEVLRDT
ERFAKDPRGWRALNEGRIPPDCPVGPMMMYRPNALFNDGEAHARLRGAIT
DSLTRLDPYALSEYVERSADTLINAFADRGEADLLADYAAAIPLLVFNEL
FGYPAEHGLRLVGTMARLFDSGEDAAEANQELLEYMAGLIAAKRERPAAD
ITSWMLAHPSRLADDELLQQLMLILAAGTEPQLNLIANALRLLLSDDRFA
GELSGGSLPVQDAIDEVLWTDPPLANFGTRFARHDLDLAGLRIRQGEPIL
TSYAAANTDPELISDGRFGNRAHLAWSIGAHRCPAESPARVIASVAIEKL
LDRLPDMELAVPVDQLAWRTGPFHRALTALPVRFPVTARPTAAAAPAAVS
AAVSPPAPAAAPAKPHGSPQTAPDASDTPSQSPRAAQRRRWGSLAAWWRGQ

CYP156D1 Streptomyces scabies SCAB32121

MTTTAPLYLP HAYRLYEPGF AQDPHAYYTH MRAHFGDVAP IEISPGVFGH LVIGYRLALQ
LLRDTQTWSK DPTVWVSHLP KDSPVLGMLG PRPNPLFADG ERHARYRRVI TDSFGRIQPH
HLRDLVREIA ALLIGRFAGA GIADLIAQYA RPIPSYVMNR LFGQPDHAAP RLVTALAGLI
EGGENAAAAN AEFEAYMRRL LALKTGERGH DLTSWIMDHS AGLSPEEVLH HVVLTVGAGQ
EPTTNLIANA LAIMLSDDRY YAGVTNGALA PIHAVHRVLR DEPPMANYAA HYPRHNVRIN
NLSIPAHSLV MVSFAAANAD PQGPGAPLSG EGSHLAWSAG PHACPVKDPA ILIAVTAIEE
ITSRLPDLEL DGRREDLQRR IGPFHTAYRH IPATFTPLTA LPTTGDRAWP GNPFRTSSTP
PDAISPQKPP ACAPSAPPCA

CYP156E1 SBI_8426 Streptomyces bingchengensis

52% to CYP156C1 Streptomyces scabies SCAB20221
VSQPYESVAQPTAVPPPGCPAHAGGTGTGTGTGAEPLYTPEFFQDPYAVY
KRLRETHGPLAPVEIEPGVTAVLCVGYETALEIMRRPETFSKDARNWRAM
TEGRVPEATHAAQLIKPRAQAGWVDGEAHRRLRSAIDDSMSRIDLGALRG
YVERIADSLIDQFAAAGEADLIPEYCQLVSMLAVGELFGCPKDIADRLFA
AMAGLLDGRDPMAAAQEIDATMRALIELKRREPGPDVTSWLIAHPARLND
EEMVEQLLLMMGMGSEPVPSLISNALRVLLTDERFAGDLAGGGMLVEDAL
DEVLWTDPPLSNLAVHFPLRDVTVSGTRLRAGEPVIISFAGGNQDALDSS
QHKQGNRAHLAFSAGPHTCSGRNQGRLIATAAIEKLLDRIPDIELAVDAE
KLEWRPGMYQRGLTALPVRFAPVGELSKSEPAAPAAPAPQVPAAPEVPPA
PTGLPAVPDAEGAAGEPGGAPGDADAAKPKPTGLLGFLARWRRSRK

CYP156F1 SBI_8398 Streptomyces bingchengensis

56% to CYP156B2 Streptomyces scabies SCAB79211
missing N-term 165 amino acids
MLPLLVFNELFGCSPSIGDRLVIGTSGIFDASMDAEKANEELTQALIELI
ALKRRQPGDDVTSRLMAHPAKLTDEEMIHQLVMLISAGTEPQRNLIANGL
YLLLCDEKHAGGSQAGGLLVEDVIDDVLWNSPPMANYAPHYPVCDVELGG
NLLRAGDLVLISFAGANTDPALSSSRQILSKRAHLAWSAGPHACPAKDSG
QLIAVGAIENLLNQLPDVELAVPMESLQWRPGPFHRALTSLPARFAPVRA
QQTAMMSPAAQTGPVVTPAAIPQTRPQGKVQKSSAWSSFLAWWKS

CYP157A1 Streptomyces coelicolor cosmid 6D11

MSTDAHDVPGAVPLGGPRFQTDPALLYRQMRREHGAVTPVVLDG
DVPAWLVLGYRELHQVTGDPVLFSRDSDLWNQWENIPDDWPLLPMIGRRQPSILYTVG
ERHRERAAMISDALEAVDPHLLRGHAERFADELVDRLCAKGEADLVGDYAMLLPVRVL
ARLYGFPDEQGPALVTALNDMIDGRERALAGQTHLGTSMARLLADRKAAPADDVASRM
LADESGFTEEEVAQDLMVMMAAGHQPTADWIGNSLRLMLTDDRFAASLFGGRNSVAEA
MNEVLWEDTPTQNVAGRWAARDTQLGGRRIRAGDLVLLGLQGANSDPQVRTDGSALTG
GNNAHFSFGHGEHRCPFPAQEVAEVIARTGIEVVLDRLPDIDLAVPAGSLTRRPSPWL
RGLTELPVRFTPTTALGGTSA

CYP157A2 Streptomyces avermitilis

MTPAPAPAPVPLSGPRFQTDPAALYREMRREHGSVAPVLLDGDI
PAWLVLGYRELHQVTGDPVLFSRDSELWNQWPNIPADWPLLPMIGHKQPSILYTVGER
HRERAAMISDALEAVDPFELRSLTEKFADELIDAVCAKGETDLVADYAALLPVRVLAL
LYGFAEEQGPGLVTALNDMIDGRDRAIAGQTHLATSMAQLLADRKAEPANDVVSRMLA
DSGGFTDEEIAQDLMVMMAAGHQPTADWIGNSLRLMLTDERFAASLFGGRNSVAEAMN
EVLWEDTPTQNVAGRWASRDTQLGGRRVRAGDLLLLGLQGANNDPQVRIDGAALTGGN
NAHFSFGHGEHRCPFPAQEIAEVIARTGIEVVLDRLPDIDLALPAGSLARRPSPWLRG
LTELPVKFTPIPALGGSPA

CYP157A3 Thermobifida fusca

MGPAVHRGARRSRPRRRPPTRRLLVLHRPAGGARHSLRRRPQQL
RVLLHPGPDPRGTRPGPLSPPPGMRRPGTRVRQTGAGHPGPTCDDDHRGGGRPMNAQR
GIPSSHQNAFRLYGPQFQNKPAELYRQMRTDYGPVAPVLLDGDIPAWLVIGYREVTHV
LNHPETFARSSRRWNAWDLVPENWPLYPMVTRTPNILYSEGEEHRRRATAISDALSGA
DQHEVRQYAVQAADRLIDGFCAASRADLRADYASRLPAIVLGRLYGLDQKHAEVLAEA
MTTMIDSGPDAVKAQQFLLQTMGTLVAERRKQPGPDVVSRLVHHPAKLRDEELIPDLV
VILGGGHQPTTEWLGNTLRLMLTDDRFAASLTGARSSVREALNEVLWEDTPTQIYLGR
YAAHDVELGGQLIRRGDLVLLGLAGANSDPQINPGPECRMSQGNQAYLSFSHGEHRCP
YPAPELAEIIVTAGIEVLLDRLPDVELAVPVDELRWRPSPWMRGLVALPVVFTPVPPI
GGQ

CYP157A4 Streptomyces scabies SCAB51111

MDFATSDADG DQPFPTSALP PSASAPVPLL GARFRGAPAP LYRDLRREHG EVAPVLLDGG
VPAWLVLGYS ELHQVTSDPE LFSRDSGLWN QWRNIPADWP LLPVISPRQP SVLGTTGERH
RQRAALIEEA LEAVEPLELR GQVERFADEL IDEVCGVGAA DLVGQFAALL PVRVLACLFG
FREDHGPGLV AALNDILDGQ DRAMAAEGFL RTAMDRLVSE RLAQPGDDVV SRLLARARAY
EVTVEEVTHD VMVMLAVGHQ PTADWIGNSL HLMLTDERFA ASLFGGRSSV AEAMNEVLWE
DAPIQNAAGR WTTRDTRLGG RVLRAGDLVL LGLQGANSDP RVRTRGDALT GGNNAHFSFG
HGEHRCPFPA QETAEVIART GIEVVLDRLP DMDLTVPPTS LPRRASPWLR GLVELPVRFS
PGPVRGA

CYP157A6 Streptomyces cyaneofuscatus IT17-157 AB426723.1

80% to CYP157A1 Streptomyces coelicolor
MTTTSGTPGTASGCPVTHGSVPLSGPRFQSDPVQLYRDMRRDHG
AVAPVVLDGDVPAWLVLGYRELHQVTGDPALFSRDSDLWNQWDRIPDDWPLLPMIGRK
QPSILYTVGERHSVRAMMISNALEGVDPFSLKRYAEEFADELIDRFCTKGAVDIIAEY
AKLLPALVLARIYGFSDEEAYPLVGAINDMIDGRERALAGQQHLATSMFQLLADKHAE
PGDDVASRMIADVGGFTDEEVAQDLMVMMAAGHQPTADWMGNSLRLMLTDDRFAASLS
GGRHSVAEAMNEVLWEDTPTQNVAGRWAARDTHLGGRHIRAGDLLLLGIAAANGDPQV
RTHASALTGGNNAFLSFGHGEHRCPFPAQETAEVIARTGIEVLLDRLPDVDLAVPAEQ
LTRRPSPWLRGLTDLPVLFTPTPALGRPGSLGGPA

CYP157A7 SGR1086 Streptomyces griseus

MTNPSSATPASTAGTGGGCPVGAGTGAVPLGGPGFLAEPREFYRSLRRDHGPVVPVELPGGLPAWLVIGYRELHQVTSDGEMFPRDVSLWNQWENVPADWPLLPMVGTPMPSIYFTAGAEHRRHVDMVVPALEEADPFEIRRHCEQLADRLIDAVCTRGTADLVAEYAEPLPVLVL
ARLVGFPDDEGADIARVLKDLADGGPGAQKAHLSFGEHMQRLVAAKRARPGDDVTSRMLAHPEPFTDQEYALDLMAITAAGHLTTADWISNSTRLMLTEDQFADALSGGRHSVAEAMNEVLWEDGPTQILAGRWAARDARLGGRDIARGDMLLLGLGAANADPHIRQQVTASA
VRSGQGGNSAHLAFSHGEYRCPFPAQEIAEIIARTGIEVLLDRLPDLELAVPATELVRRPSAFLRGTTALPVRFTPVRTTGDAL

CYP157A8 SGR3107 Streptomyces griseus

MTTVSGCPVTHTSVPLSGPRFQSDPVQLYREMRRDHGAIAPVVLDGDVPAWLVLGYRELHQVTGDPVLFSRDSDLWNQWDRIPDDWPLLPMIGRKQNSILYTVGERHSVRAMMISNALEGVDPFSLKRYAEEFADELIDRFCTKGSVDIIAEYAKLLPALVLARIYGFSDEEAHPLVG
AINDMIDGRERALAGQQHLATSMFRLLADKHAEPGDDVASRMIADTGGFTDEEVAQDLMVMMAAGHQPTADWMGNSLRLMLTDDRFAASLSGGRHSVAEAMNEVLWEDTPTQNVAGRWAARDTHLGGRHIRAGDLLLLGLAAANGDPQVRTDGSALTGGNNAFLSFGHGEH
RCPFPAQETAEVIARTGIEVLLDRLPDVDLAVAADQLTRRPSPWLRGLTDLPVLFTPTPAIGRPGSFGGPA

CYP157B1 Streptomyces coelicolor cosmid F55

MTDIDPSPHPVAAPGCPVHPDAVPLAGLEYQQTPSELYRGLRAE
HGAVAPVLLDGGIPAWLVLGYPEVSYVTSHDELFARDSRRWNQWGSIPPDWPLLPYVG
HQPSVLFTEGEEHRRRAGVITQALAGIDQFELARDCRHLADRLIAAFAGSGRAELMSG
YAHPLPMRAAVRMCGMPHTGVETRQLVEDLRISLDAAEGDDPVAAYTRVGERIHQLVR
HKRERPGPDVTSRMLTHPAGLTDEEIVQDLISVIAAAQQPTANWIGNTLRLLLTDERF
ALNVSGGRLSVGEALNEVLWLDTPTQNFIGRWAVNDTQLGGRHIRAGDCLVLGFAAAN
TDPQLWPEAHVGAENSAHLSFSNGEHRCPYPAPLLADVVARTAVETLLERLPDLVLAL
EPGELTWRPSIWMRGLTALPALFTPVVA

CYP157B2 Streptomyces hygroscopicus subsp. yingchengensis

MGSATSELPSQRTPLTAAAETGLKIVVVGGFGVGKTTLVRSVSE
IRPLNTEELMTQAGQGIDETAGVERKTTTTVAFDFGRISLNDRMVLYLFGAPGQERFW
FLWDRLFAGTLGAVVLVDTRRMEDCWYAIDRLEHHGTPFVVAVNRFDGDEKRFSLDEV
RQALALGEHVPMIECDARVRASGKEVLIALVDHLYTRALAKESTACSDTTGFPSTDAP
PPGCPAHGSAVPLAGLEYQQTPSQLYRTLRREHGAVAPVLLDGGIPAWLVLGYPEVCY
VTAHDELFARDSRRWNQWEHIPPDWPLLPYVGYQPSVLFTEGAEHQRRAGVITQALEG
VDQFELARECQLIAARLISSFSGSGRAELMSMYAHALPARGVLWMCGMPAEDADTERL
VDDLRISLDAGEGDDPVAAYTRVGERIMRLVKEKRERPGPDVTSRMILHPAGLGDEEI
VQDLISVIAAAQQPTANWICNTLRLLLTDERFAVNVAGGRVSVGEALNEVLWLDTPTQ
NFIGRWAVRDTQLGGRHIREGDCLVLGLAAANTDPQIWPEPHAGSGNSAHLSFSNGEH
RCPYPAPLLADVMARTAVETLLEHLPDLVLAVEPEELTWRPSIWMRGLTSLPVEFTPA
MN

CYP157B3 Saccharopolyspora erythraea NRRL23338

MTGASEVEWPAADAPSDCPVQEVPAAPQEHAVRMYGPILQRDPKELYREMRREHGPVAPI
LLEGDLPAWLVLGYREVHQVTTDSELFARNSRRWNHWDDVPEGHPLWPWLGIDHSVLVSE
GEEHRRRAGAISDALAAVDQFELWDHCARIADRLIDSFAGSGRADLIAEYTDRIPLLVVT
TMFGMTEEQTRNLIGDLSTTIDAAEGAGAAHNRVVDRMRALLAVKRERPGNDLPTRLLGH
PSTADDDECAIDLVILLTAAHQPTASWIGNTLRLLLTDERFALTLSGGRRSVGDALNEVL
WEDSPVSNLLGRWAARDTQLGGRAIRKGDLLLLGYNAANSDPQVWPDGTNAHMAGNHAHM
AFGHGEHGCPFPAPELAEVIAKSTIEVLLDRLPDLRLAVEPEALRWRQSTTIRGLVDLPV
EFSPTYAKRP

CYP157B4 SBI_9885 Streptomyces bingchengensis

56% to CYP157B2 Streptomyces hygroscopicus subsp. yingchengensis
VTNVHHPSPVDGPSPLTGCPAHPGAVRMHTEELQADPAELYRRLRRDHGA
VAPILLDGDIPAWLVLGYRELHRVTSDPTLFARDSRRWHAWEYIPADWPL
MPFVGYRPTMLFAEGAEHERRAEAMFDALASVDQFELRAESERVADELID
VFAGSGRAELVADYASQVPIRVVTRLFGLAPDTAVAIQRDTVEMVTANDG
SXLPPANDGSVAAYQRVHNRMVTLMAEVRRNPGMPGIPAQMAAHRAALTD
EEIVNDLIGTVYASHQSTTDWIGNALGLMLTDERFAVTMAGGRRSIGQAL
NEVLWENTPVPAFIGRWAAEDTILGGQRIKKGDCLVLGLAAANADPSVRP
DFRADASGNQAHMSFSHGEHSCPVPARELAEVISMTAIEVLLDRLPDVVL
AVSPEELVWRSSIWLRGIAALPVEFTPALG

CYP157B5 SBI_9382 Streptomyces bingchengensis

62% to CYP157B4
53% to CYP157D1 Frankia alni ACN14a
VTTPDPTLPPEDPDTSAAPLPGWPEQPDAVLLHAEDFSRSQEDLYRRLRR
DHGPVVPVLLDGQIPVWMVLGYRELVRVTTDPNVFARDSRRWHSWHLVPP
DWELMTFVGYRPTMLFTEGAEHERRAEAIIDSMEIVDAFELRALCERVAD
GLIDTFAGRGHADLIADYACQIPLRVLNRMYGMNEAESAELQQVTVDLVS
GKGGPEAHQNMVDRMVALMEHARATPDRKNISTVLVNHPAGLTDEEIIND
LLGNVYAAHQPTTDLIGNALRLMLTDERFAVTMSGGRRSVGQAINEVLWE
ATPVPNWVGRWAAEDTMLAGRHIRKGDCLMLGLAAANADPDVRPDFRSGA
AGNQAHMAFSHGTHGCPPVARELAEAIAMAAIEVLIDRLPDVSLTAAPED
LEWRSKLMMRGVSAIPVQFTPTSR

CYP157B9 SGR4392 Streptomyces griseus

MSTSSPSFGPQAPASCPVGAGAGAVRLSGASYQQTPTQLYRSLRRDHGAVAPVLLDGDVPAWLVLGYAELSYVLTHDELFARDSRRWNQWETIPPDWPLMPFVGYQPSVLFTEGDEHRRRAGVITEALEGIDQFELARDCRRIADRLIADFAGSGRTELMSSYVHALPMRAVVEMC
GMPVSGSDTQQLVDDLRISLDAGEGDDPVAAYGRVGDRLRQLVEDKRAAPGADITSRMVTHGAGLTDEEIVQDLISVIAAAQQPTANWICNTLRLLLTDERFALNVSGGRLSVGEALNEVLWLDTPTQNFIGRWAVRDTQLGGRHIRAGDCLVLGLAAANTDPEIWPESYVGAENS
AHLSFSGGEHRCPYPAPLLADVMARTAVETLLEQLPDLMLAVDPTELSWRPSIWMRGLSTLPVQFSPMAQ

CYP157C1 Streptomyces coelicolor cosmid I41

MTPESHSPTGTGEPLLEPPPGCPAHGLGPGGLHRLHEAEDLEEL
YEKLREQHGPVAPALLHDDVPMWVVLGHAENLHMVSTPSQFCRDSRIWTPLNEGMVKP
DHPLMPHIAWQPICSHAEGDEHKRLRGAVTSAMSDLDYRELRRHIKRYTQRVVNRFCE
EGRADLVSQFAEHLPMGVMCHLLGMPEEYNDRLVEAARDTLKGTETAIASHAYVMEAL
GRLTATRRADPADDIAGRLVTHPAGLTDDEVREHLRVVLLAAYEATVNLIGNVMRVVL
TDPGFRAQLSGGQMTVPQAVEQSLWDEPPFSTVFAYFAKQETELGGQRIRAGDGLLLG
IAPGNVDPRIRPDLDASMMGNRAHLAFGGGPHECPGQDIGRAIADAGIDALLMRLPDL
QLDCDEDDLRWRSSIASRHLVELPVRFEPRAQQDIMQQPSHAPTPERHAPWHVGLPKP
ERRAQPPLPAQPPQPVSVTAAEPQQAPGAGQPRPRGAWQRFLLWWRGY

CYP157C2 Streptomyces avermitilis

MTPEPHPSTGTDDPTFGPPPGCPAHDPGLGGVRRLYGPEAEDLG
DLYEKLRAEHGAVAPVLLHNDVPMWVVLGHTENLHMVRSPSQYTRDSRVWTPVLDGTA
GPDHPLMPHIAWQPICSHAEGDEHLRLRGAVSGAISTIDHRGIRRYINRSSQALVNRF
CEEGRADLVGQFAEHLPMAVMCEILGMPDEYNDRMVQAARDMLKGTETAIASNAYVMD
ALMRLTARRRAHPEGDFTSHLINHPAQLSDDEVGQHLRLVLIAAYEATTNLLANVLRM
VLTDPRFRAQLNGGQMTVPEAVEQSLWDEPPFSTVLGYFAKQETELGGQLIRKGDGLL
LGIAPGNVDPHVRPDLSANMQGNRSHLAFGGGPHECPGQDVGRAIADVGVDALLMRLP
DVQLDCAEDELRWTASISSRHLVELPVRFAPKEPQDVSQRPSLRPLPQPVPSRPVRTQ
QPQATTPPPAPPAPPAAAPERGPGAWQRFLRWWRGY

CYP157C3 Streptomyces griseus

MTTPFHHEPGTVPPPQCPAHNLDIGPGGLRRLHGPEAENNPAGL
YDKLRAEHGTVAPILLHGDVPAWLVLGHSENLHVTRTPSQFSRDSRRWRALQDGSVAP
DHPLAPIFTWQPICVFADGPKHERQRGAVTDSMERIDTRGVRRHINRFSNRLVNDFCE
KGTADLVGQFAEHLPMMVVCAIFGMPEEYDERLVQAARDMTRGTETAVASNAHIVSVL
TRLVERRRAEPSPDLASWLVEHPATMTDTEVIEHLRLIMIAAYESTANLIANVLRMVL
IDPRFRARLSGGHMTVPEAVEQTLWDEPPFTAVFGRWAVGDTELGGQQIKAGDALLVG
IAPANTDPTVRPDLGADMGGNRAHLAFSGGPHECPGQDIGRAIADVGVDALLMRLPDL
ELGVGESELHWVGNIMSRHLVELPVKFAPGPQQKLDADPLTVMARLLAPPTPGRSPPR
PGRSPSPATRGPWRRAHAPGAAPTAEPDPAPAAPPAPEPAAAPEPAPVATIPQQRRPA
APARFWQAVTRWWSGY

CYP157C4 Streptomyces peucetius

MTTPEPSVPPGPVPPPGCPAHGMSPDALRRLYGAEAEADPQALYEVLRKEHGQVAPVLLH
GDLPAWLVLGHRENLEVMRSPSRFSNNSRLWSMFQQGRVGQDSPLLPIVGWQPICVFADG
ADHERLRSAVRDGLEQFDRRGIRRYVIRYTNQLVDSFAATGQADLIGDFAEKLPMLVMTQ
LFGMPEEYGPRLVDAALDLMKGSETALASNELVVDTLRTLAERKKAKPGHDFTTWLIGHE
ADLTDDEVMEHLRLVLVAANETTVNLIANTLRMVLTDRRFRANLAGGHMTLPDALEQVLW
DEPPLSVITGRWATGDTVLGGKQISKGDMLLLGLAAGNVDPEIRPDLQKPLMGNRAHLAF
SSGPHECPGQDIGRAIADTGIDTLLARLPDLQLGVSEGELRSSATWLSQRLESLPVRFTP
PGSTGGGGKESVNFASTMPGPLPATVPAPVPDASPAGQPKKRPVAKSWRSLFHRGG*

CYP157C5 Streptomyces scabies SCAB73721

MTPESHSLTG TDDPTLGPPP GCPAHGTGPG GIRRLYGPEA EDLGAVYEKL RAEHGPVAPA
LLHDDVPIWV VLGHGENMHM VSTPSQYSRD TRLWNKLQDG TFKPDNPLMP HIAWQPICCH
AEGDEHLRLR GAVTGAMSTI NFRGIRRSIN RYTQQLVNEF CEEGEADLVG QFAEHLPMAV
MCEILGMAEE YNDQIVHAAR DMLKGTETAI ASNAYIMEAL MRLTVRRRAE PQEDFTSHLI
NHPARLTDEE VGQHLRVVLI AAYEATTNLL ANVLRVVLTN PGFRAQLKGG QMTVPEAVEQ
SLWDEPPFST QLAYFAKQDT ELGGQRVRKG DGLLFGIAPG NVDPRVRPDL TANMQGNRSH
LAFGGGPHEC PGQDTGRAIA DVGVDALLAR LPDIRLNCEE SELRWRASIS TRHLVRLPVR
FEPKEREALE LRPVGRPVPA QREGRQTVTP DTPLQAASPE PRPATPAPDA EPKGRPGLLR
RALRWLSGR

CYP157C6 Frankia sp. CcI3 old ver = 157C1 but name conflict

MSTPIPEAGAESGAAIPPPGCPAHAAFAQDAVRTALYGPEAQHDPGAVYEKLRAEHGGIAPVELEGGVPA
WLVLGYRENMEVARTPSRFTRDARLWRDWNEGRIAADDPLLPLIGWRPDVVSYDGEEHARLRAAVNECLT
RFDRHGTRRHVQRYANQLIDGFVEDGRADLVTQFAVYLPMLVLSRLVGLSEGYGRKLVEAIVGMVSGGED
AYAHNQYIIGTLRSLTEERRRAPAHDLASWFVQHPSGLNDEEVLNHLRLVIVLGYEATANLVSNTLRMVL
TDPRFRASLAGGLMTLPDAVEQMLWDDPPLLVCPARFATHDMHFADKEIREGDMLLLGIAAGNADPEIRP
DLGAPMHGNRSHLAFSRGPHECSGQEIARAITDTGVDVLLNRLPDLHLTVPEEQLTWTASTWSRHLDALP
VKFAPQCRPVPQSAPAAPAFSAPVVEPSAAKDALAAVAEADAQARADTRRGFWASLGGMFRGRR

CYP157C7 SBI_7811 Streptomyces bingchengensis

60% to CYP157C4 Streptomyces peucetius
VTPPPDHPGTDHLGTAPPPGCPAHAAIRSGTAGDLFGPEHEADPKGFYEW
LRAEHGAVAPVRLAGDLPAWLLLGYRENLEVARTPSRFSRDSRHWGDWRE
GRVASDSPLLPVVGWQPMCTFADGAEHERLRAALTESMNRFDRRGMRRQV
TRFTHQLVDEFAADGHAELVSGIAEQLPMLVLTHLLGMPDEYGPRLVEAT
RDLMKGTETALSSNAYVTETLENLVARKRAEPGSDLASWLLEHPSGLTEE
EVVQHLRLVLLTGNETTTNLMANTLRTVLTDPRFRASLAGGHMTLPDAIE
HVLWNEPPLAVIPGRWATGDTELGGRQIRAGDMLLLGLAAGNVDPAVRPD
IAAPMYGNRSHLSFSGGPHECPGQDIGRAIADTGIDTLLLRLPDLRLAVP
ETELSWTASWISRHLVSLPAEFTPRGGDSDTLETETGLLAPDFLARSAPQ
PDPPDQSKALDRPNTPDRPDVRRSSRRRSWWRSLWRRLRPGPRPPRR

CYP157C10 SGR1059 Streptomyces griseus

MTTPFHHEPGTVPPPQCPAHNLDIGPGGLRRLHGPEAENNPAGLYDKLRAEHGTVAPILLHGDVPAWLVLGHSENLHVTRTPSQFSRDSRRWRALQDGSVAPDHPLAPIFTWQPICVFADGAKHERQRGAVTDSMERIDTRGVRRHINRFSNRLVNDFCEKGTADLVGQFAEHLPMM
VVCAIFGMPEEYDERLVQAARDMTRGTETAVASNAHIVSVLTRLVERRRAEPSPDLASWLVEHPATMTDTEVIEHLRLIMIAAYESTANLIANVLRMVLIDPRFRARLSGGHMTVPEAVEQTLWDEPPFTAVFGRWAVGDTELGGQQIKAGDALLVGIAPANTDPTVRPDLGADMGG
NRAHLAFSGGPHECPGQDIGRAIADVGVDALLMRLPDLELGVGESELHWVGNIMSRHLVELPVKFAPGPQQKLDADPLTVMARAPRPADAWEISSPARQVPEPRHEAVVAQPAHAPGAAPTAEPDPAPAAPPAPEPAAAPEPAPVATIPQQRRPAAPARFWQAVTRWWSGY

CYP157D1 Frankia alni ACN14a

MTPPSHDRVDTWAPAPAAPELAAPAPGFPDHPGAVRLYGPRFQHNPAQMYREMRRVHGPVAPILLDGDIP
AWLVLGYRELHYVTSNPELYGRDPRRWNAWDRVPPDWPLLPVVGYQPYTMHLEGAEFERRSAIMNDVLGD
VDLFELRALCERTCDELIDGFAGRGEADLITEYAQSMPMLLIGRMIGIPEAGLPELLASMNAATDGSGPE
AVAGHSRFVAIINALLADRRARPRPDLPSAMLGHPGKLTDEEASWDLLLIVGIGQQPITDWIGNTLRLML
TDSRFAVTLSGGRRSVGQALNEVLWEDTPLQNMSGRWAVRSTQLAGQHIQAGDMLVLSCAAANGDPQVRP
DSFEGPGGNHAHMSFGHGEHRCPYPAQEIAETIVRGAVEVLLDRLPDAVLAVSPDALVWRPSPWMRGLSA
LPVHFSPS

CYP157D2 Frankia sp. EAN1pec YP_001509751.1

MTTAREPARESLRGPAREPAREPARAARERPPGGRTPPCHLGEAQFQGGPARAYRDLRRKHGAVAPVLLD
GGLPAWLVLGYRELHYVLSHPEIFAHDPRHWAGWDDVPPDWAALPGVGHRPSVLRAEGAEHRRRYTAIQD
VLGAVDLFELRARAEEITDDVIDAFAGRGETDLIDSFAHRVPALVLASLCGPPEVDTAGLVHDLIVLIDD
GPDAAESHQRVLDRLRWLLADRREHPDDDIVSRLIAHPAGLADEEVVEDLAVVFGFGARAVAGWIGNSLR
LLLTDGSFALDLSGGRRSVMQALNQVLWEDTPMQVVAGRWATRNTQLGGQRIEAGDMIALGLGAGNADPQ
VRRGHAPDTQTGAGTSANSAHLSFGHGEHRCPYPAQEIAEVVTRTAVEALLDRLPNMWIAVPADALGWRR
TAWNRALTALPVRFSPV

CYP157E1 Frankia sp. EAN1pec YP_001509752.1

MTHPNPRQLGTCASGMPRAFGAVRQLGALRQYGASCPAPTTRRGGPEDTPSGEPVPGPSSGPPSGPRGGP
VRGTAGAHPPARPDLDARWPAHATAVRLPADGPGDDRAAFYRRIRDEHGPVAPVLLEGDVPAWLVLGYRE
VVYVAGTPALFGRDCRIWNAWDLVPPAWPLQSMVGQRPSLRALDGPAHARRLGAIGDVLGMFEPHGLRAR
AASGADALIDAMASDGRAELMTQYASPLPAMVAAGMWGLPDTDLTALARDLTLLVSGGTGARDARRRAHA
MLTRVVRRRRAQPGDDAVSALLTHPAGLRDDEVVEDVMATLIAGQAPTADWIGNTLRLMLTDPRFATDLA
GGRLSAGDAMAEVLWADPPIQNLVARWARRDVRLGGRWIRAGDLLIFGLSAANSDPWARPQPSGRPSGNH
AHLAFGHGEHRCPFPAQMTAETIATTAIEVLLDRLPDLELAVEPRDLRWRPSVWARGVAALPVRFTPP

CYP157F1 SBI_871 Streptomyces bingchengensis

47% to CYP157C6 Frankia sp. CcI3
missing about 33 aa at N-term
VPLYGAAPAGDMPALYERMRRDHGPVVPVAIAPGIEAWLVLGHRELLHLT
RDEQHFSHDPRRWTPLRDGRVPPDSPLIPLVGWRPALLFADGQQHRRMRS
AVAEALGRLDGHELIRMVRSAAERLIAGFADRRKADLVPQYARLLPLQVV
TQILGLDEERGPRLVEAIAAIVNPTAAATGANRRMGGILLELIEQKKRQP
GADLTSWLLEHPVGLSDQEVLHNLVVIIVAGNQTTVNWIADTVRILLTDP
GFRSSLARGHLTVDDALDLVLWRHPPTANFPGRYATRDLRFGGQHIRAGD
MLILGLAGANADPEVLPEDGRPVIGNRSHLAFGAGPHTCPARDPARLITR
TAVDTLRHRLPDLELAVPEDQLAWITSPWSKNLAGLPVRFTAPQLAADAA
DSADAAAAGHPADSGDLR

CYP157G1 SBI_4984 Streptomyces bingchengensis

50% to CYP157B3 Saccharopolyspora erythraea NRRL23338
VTNPQDPQDLQDPQPPRSAPDTPPPGCPAHAARLYGPDFRREPAETYRRI
RREGQVTRVLLEGDVPVWFVVGYRETRQVLSDVETYGRDPRRWNGWDSVP
PDWSLMPWVQYSPMMPFTEGEEHLQRAAAVSEVLATLDPFVLRGHCERFA
DQLIDKFAVTGRADLVYDYIYSVPTLVMGEVFGLAEDEAGLAALAEGLTT
SFVSREDAMAGQQRAAAYVAGLVKAKREAPGPDLTSRFIQSTPNLTEEQH
IADVMMLMAAALPLTSYWIGNTLRLLLTDERFATTLTGNRRSIGQAMNEV
LWVDTPLQNLIGRYATRDTVLGGQRIRTGDLVVLGLAAANADPLLWPDGH
VGHAGNHSHVAFSGGEYGCPVGGPETARIIAETTIEVLLDRVPDLALAVA
PEELRWMDSVWYRCLESLPVAFTPTGVMGG

CYP158A1 Streptomyces coelicolor cosmid 8F11

MTQETTTLTGQSPPPVRDWPALDLDGPEFDPVLAELMREGPLTR
VRLPHGEGWAWLATRYDDVKAITNDPRFGRAEVTQRQITRLAPHFKPRPGSLAFADQP
DHNRLRRAVAGAFTVGATKRLRPRAQEILDGLVDGILAEGPPADLVERVLEPFPIAVV
SEVMGVPAADRERVHSWTRQIISTSGGAEAAERAKRGLYGWITETVRARAGSEGGDVY
SMLGAAVGRGEVGETEAVGLAGPLQIGGEAVTHNVGQMLYLLLTRRELMARMRERPGA
RGTALDELLRWISHRTSVGLARIALEDVEVHGTRIAAGEPVYVSYLAANRDPDVFPDP
DRIDLDRDPNPHLAYGNGHHFCTGAVLARMQTELLVDTLLERLPGLRLAVPAEQVAWR
RKTMIRGPRTLPCTW

CYP158A2 Streptomyces coelicolor 2StG58 [Full Sequence] MTEETISQAVPPVRDWPAVDLPGSDFDPVLTELMREGPVTRISL

PNGEGWAWLVTRHDDVRLVTNDPRFGREAVMDRQVTRLAPHFIPARGAVGFLDPPDHT
RLRRSVAAAFTARGVERVRERSRGMLDELVDAMLRAGPPADLTEAVLSPFPIAVICEL
MGVPATDRHSMHTWTQLILSSSHGAEVSERAKNEMNAYFSDLIGLRSDSAGEDVTSLL
GAAVGRDEITLSEAVGLAVLLQIGGEAVTNNSGQMFHLLLSRPELAERLRSEPEIRPR
AIDELLRWIPHRNAVGLSRIALEDVEIKGVRIRAGDAVYVSYLAANRDPEVFPDPDRI
DFERSPNPHVSFGFGPHYCPGGMLARLESELLVDAVLDRVPGLKLAVAPEDVPFKKGA
LIRGPEALPVTW

CYP158A3 Streptomyces avermitilis

MTEKTITEALPPVRHWPALNLTGVEFDPVLSQLMSEGPVSRIQLPNGEGW
AWLVTRYDDVRMVANDPRFSRAAVMGRQVTRLAPHFIPTAGAVGFLDPPD
HTRLRRSVAAAFTARGVERVREKSRRMLDELIDELLRGGPPADLVETVLS
PFPIAVVCELMGVPAADRHSMHTWTQLILSSAHGAEVSEKARNDMGAHFE
RLIGERRGSTGEDVTSLLGAAVGSGEITLDEAVGLAVLIQIGGEAVTNNS
GQLFYILLTRPDLAERLRAEPKIRPQGIDELLRYIPHRNAVGLSRIATED
IEIRGVRIREGDTVYVSYLAANRDPDVFPDPERIDLTRSPNPHVSFGFGP
HYCVGGMLARLESELLVEALLDRVPGLRLAVPPGLVPFKKGALIRGPEAL
PVTW

CYP158B1 Saccharopolyspora erythraea NRRL23338

MTDRCPARMYDPADLPGMTFDPVFLELLRDEPVARIRMRYGEGE
AWLLTRYEDVKFVTSDPRFSRKIMGRPFPKMTKHHIPMDRAISFSDPPEHARVRRVVA
RDFSPGSIERLRPTGREIMHRYLDELVASGPPADLVRHVTSPFPMAVLGELMGIPESD
RQWLIDCSSQVLSMAPDQAAVDRINGIKAEVAEYFLALVESRRADPRDDVVSTVAAAR
ERGDLDDEEVGAMTVLLALNGWHAVRNNSTNMVYVLLTDPELRSRLKADLALVPTAVE
ELLRYIPHKRGIGQPRIATEDVDIRGVRISKGDVVYVSYIAANWDEEVYPEPDRVDLD
RPEVPHLAFGHGPHYCMGPMLARMESQVLLSSLLTRLPDLALAVPPEQVAWQPNALIR
GPVELPVTW

CYP159A1 Streptomyces coelicolor cosmid F55

MSTAQQVPDILSPEFAANPYPAYRTMRDSAPLIRHEATQSWIVS
RYEDVERVFKDRAGQFTTENYDWQIEPVHGRTILQLSGREHAVRRALVAPAFRGADLQ
ERFLPVIERNSRELIDAFRHTGRADLVADYATRFPVNVIADMLGLDKADHDRFHGWYT
SVIAFLGNLSGDQEVAAAGARTRTEFAEYMIPVIRERRENPGDDLLSTLCAAEVDGVR
MSDEDIKAFCSLLLAAGGETTDKAIAGIFANLLAHPEQLAAVREDRSLIPRAFAETLR
YTPPVHMIMRQTATDVTLSGGTIPAGATVTCLIGAANRDETRYRDPDRFDIMRDDLTT
TTAFSAAADHLAFALGRHFCVGALLAKAEVEIGVGQLLDALPGLRTEDGFEVVERGVF
TRGPQSLPVRFTPAA

CYP159A2 Streptomyces hygroscopicus subsp. yingchengensis

MSAAHHLPDILSPEFAANPYPAYAVMREKEPLIWHEATQSYIIS
RYEDVERVFKDKKAEFTTDNYNWQLEPVHGKTILQLSGREHAVRRALVAPAFRGSDLE
QKFLPVIERNSRELIDAFRHTGSADIVNDYATRFPVNVIADMLGLDKADHARFHGWYT
AVIAFLGNLSGDPEVAAAGERTRVEFAEYMLPVIRERRANPGDDLLSTLCAAEVDGVR
MSDEDIKAFCSLLLAAGGETTDKAIAGILANLLSHPDQLAAVRADRSLIPAAFAETLR
YTPPVQMIMRQSATDVEVTGGTIPAGATVTCLIGAANRDERRYRDPDRFDIFRDDLAT
TSAFSAAAGHLAFALGRHFCVGALLAKAEVEVGLNQLLDAMPDLRLADGHDLVEQGVF
TRGPKTLPVRFTPVTA

CYP159A3 Frankia alni ACN14a

MTTTPTTVPEKPDVLSAEFARDPHTYYKIMRDFYPVLHHEVSGYYFVSRY
EDVARIYKDSVGFSNENYAFQMEPVIGKTVIQMGGREHAINRQLITPALR
GNYLEELLPQVDELATEMIDKFRTAGRVDLAEDFTKWFPINVIVKMLDLP
REDLPKFHEWYSSLMAFLANLTNDPEIHAWGMRTQQEYPAYILPIIAERR
RNPGTDLISRLTQAEINDEQFSDEQIKALIGLLLIAGGETTDKSIASTLK
YLIMHPEQLEAVRQDPSLATRALVETLRYHPPVQIILRTTTDDVEVAGTV
IPVGSVVGCVNGAANRDERRFDDPDTYNIFRTDINIRQAFAGSADHIAFA
LGRHFCVGSLLAKREAETAINQILAAMPDIRFADGIEPTDAGLFTRGPES
LIVEFTPAS*

CYP159A5 SGR4391 Streptomyces griseus

MFMSVPAPDILSPEFERDPYRAYRLMRQDTPLMWHEATGSYIVSRYEDVERVFKDKEGEFTTENYDWQIEPVHGRTILQLSGREHAVRRALVAPAFRGSDLREKFLPVIERNSRELIDGFRDAGSADLVADYATRFPVNVIADMLGLDKSDYERFHGWYTAVIAFLGNLSGDAEVAR
AGERTRVEFAEYMLPIIRKRREAPGDDLLSTLCTAEVDGVRMGDEDIKAFCSLLLAAGGETTDKAIAGIFTNLLRHPEQLEAVRADRGLIPRAFAETLRYTPPVHMIMRKSATEVELSGGTVPAGVTVTCLIGAANRDEDRYRNPDSFDIFREDLTATNAFSAAADHLAFALGRHFCVG
ALLAKAEVEIGVGQLLDAMPDLRLADGFDPVERGVFTRGPQSLPVRFTPVSG

CYP160A1 Streptomyces lavendulae LinA homolog.

MTSAAPPAFPFPPGPGGTVPPEYARLLTDDPVAEVRLADGSRIW
LVTRHEDVRTVLTDGRFSRHRAAMLPGSGFGRSQGSGIVDLDPPEHGRLRGPVVAAFG
ASRTARFAPRIEAAAEAALDRLPAGSGTVDLVAAYTAPFAGRVTAEFLGLPGDRWQDV
TSDVELLLLPRGATEQALKEARGRLGQVLDELLAARRAEPGDSVTDTLLDAEELTDDD
RRLLLHGLIISGFITIRDLLARHLFGVLSSPGLAARLREDPSVLPSAVQELLRYYPSS
NDGLLRVATEDVVLSGRRVAAGDAVLPLVSAASRDPEVFADPHVLDIERVADRGIAFG
AGQHACPATGLAVTELTVGIGRLLAAFPRIALAVPPEEVEHSSELLPLGVRSLPVVPG
PRN

CYP161A1 Streptomyces noursei ATCC 11455 nyst.

MSTPTAPPSLKAEVPPVLRLSPLLRELQSRAPVCKVRTPAGDEG
WLVTRHTELKQLLHDDRLARAHADPANAPRYVHNPFLDLLVVDDFDLARTLHAEMRSL
FTPQFSARRVMDLTPRVEALAEGVLAHFVAQGPPADLHNDFSLPFSLSVLCALIGVPA
EEQGKLIAALTKLGELDDPARVQEGQDELFGLLSGLARRKRITPEDDVISRLCLKVPS
DERIGPIASGLLFAGLDSVASHIDLGTVLFIQHPDQLAAALADEKLMRGAVEEILRSA
KAGGSVLPRYATADVPIGDVTIRAGDLVLLDFTLVNFDRTVFDEPELFDIRRAPNPHL
TFGHGMWHCIGAPLARVNLRTAYTLLFTRLPGLRLVRPVEELRVLSGQLSAGLTELPV
TW

CYP161A2 Streptomyces natalensis

MTAASHDLPCLNLEPPKMLKLSPLLRALQDRGPIHRVRTPAGDE
AWLVTRHAELKQLLHDERIGRTHPDPPSAAQYVRSPFLDLLISDADAESGRRQHAETR
RLLTPLFSARRVLEMQPKVEEAADTLLDAFIAQGPPGDLHGELTVPFALTVLCEVIGV
PPQRRAELTTLLAGIAKLDDREGAVRAQDDLFGYVAGLVEHKRAEPGPDIISRLNDGE
LTEDRVAHLAMGLLFAGLDSVASIMDNGVVLLAAHPDQRAAALADPDVMARAVEEVLR
TARAGGSVLPPRYASEDMEFGGVTIRAGDLVLFDLGLPNFDERAFTGPEEFDAARTPN
PHLTFGHGIWHCIGAPLARLELRTMFTKLFTRLPELRPELPVEQLRLKEGQLSGGFAELRVVW

CYP161A3 Streptomyces nodosus

MVNPTPPPSLEDAAPSVLRLSPLLRELQMRAPVTKIRTPAGDEG
WLVTRHAELKQLLHDERLARAHADPANAPRYVKSPLMDLLIMDDVEAARAAHAELRTL
LTPQFSARRVLNMMPMVEGIAEQILNGFAAQEQPADLRGNFSLPYSLTVLCALIGIPL
QEQGQLLAVLGEMATLNDAESVARSQAKLFGLLTDLAGRKRAEPGDDVISRLCETVPE
DERIGPIAASLLFAGLDSVATHVDLGVVLFTQYPDQLKEALADEKLMRSGVEEILRAA
KAGGSGAALPRYATDDIEIADVTIRTGDLVLLDFTLVNFDEAVFDDADLFDIRRSPNE
HLTFGHGMWHCIGAPLARMMLKTAYTQLFTRLPGLKLASSVEELQVTSGQLNGGLTEL
PVTW

CYP161B1 Streptomyces sp. Tu6071

ABB69759
PlaO4
1 MAAQIQLPLD PPHPARPQHN LRALQKRAPV HRVSTAVGDP AWLVTGYQEI KQLLADPRLG
61 RSHHDPENAA RSGASELLDG PRGDYDTEQK WIATMRSRLQ PFFSAGHVKA MRPRVEALVG
121 ELLDRLEKQG PPADLAEALA LLLPREVIGE LLGVPVEERE LLDEWTTAVS DARDRERSAA
181 GLAALHRYGH ELAARKRAHP TQDVVSWLCE DGTLSDDQVA QLAMGVLFAG YETTATALCV
241 GTALLLDSPE QWRALRENPG LAPTAAEESV RVVSRLLPPV IRYTREDLEI AGAEVRRGEL
301 VMLDIYAATH DESIFPDPDR FDITREDNPH LCFGFGLRYC IGAPLARLEL QAALTQLTTR
361 FPRMRLTVPV EDLTVRPGSF AAIPTSLPVI W

CYP161C1 SBI_10607 Streptomyces bingchengensis

42% to CYP161B1 Streptomyces sp. Tu6071 ABB69759
40% to CYP161A2 Streptomyces natalensis
MKELPRLPFDNPAMLGIAPQMRALQQEEPITRVRTAGEDAWLVTRYDEVR
ALLADRRLGLSNPNPEQSAKSAARRFMVALMAGDDYDTEATRHAQMRALL
VPRFSTRRMRLMKTRIEHHVDDLLDQLAAGTPPVDLHRALSFPLPTMVIC
DLLGVPLADRERFGQWARGTFDQSDNQHSANTFQQVVDYITELVARKRTE
PGDDLLSELIAHKDSALSDADIAHLGNAVLLFGYETTIVRIDLGTLLLLR
NPAQRALLAENPELAPAAVEEILRLGVGGKGSNAIIPRYAHSDITVGETV
IRTGDAVMLAIGAANYDGRAFPDGDLFDLARNKPKSHLAFGHGARHCIGR
TLARIELTAVFERLFRRLPNLRLAVPEESLRWQEHRITGGFDELPVTF

CYP161C2 pntM Streptomyces arenae TU469 HQ292065

89% TO CYP161C1 SBI_10607 Streptomyces bingchenggensis
MTDLPRLPFDNPDIMGIAPQMLALQKEGPIARVGTAGEDAWLVT
RYDEVRTLLADRRLRLSNPNPQPSAKSAARAFMVALMAGDDHETEPARHAQMRSLLIP
RFSTRRLRLMKTRIEHHVDELLDQLAASAPPVDLHRVLSFRLPTMVVCDLLGVPLADR
ERFGQWARGTFDQSDNEHSANTFQQVVDYMLELVARKRVEPGDDILSELIAEKDGALS
DADIAHLGNAVLLFGYETTIVRIDLGTLLLLRNPVQRAQLAEDPGLAPAAVEEILRLG
VGGKGSNALIPRYAHGDITVGETVIRTGDAVMLAIGAANYDDRAFPDGGLFDLTRVRP
RSHLAFGHGARHCIGRTLARIELTAVFERLFRRLPDLRLAVPEESLRWQEHRITGGFD
EIPVTF

CYP161C3 PenM Streptomyces exfoliatus strain UC5319

HQ292066 84% TO CYP161C1, 81% TO CYP161C2
MNELPRLPFDNPAILGIAPQMRALQKEGPIVRVRTAGEDAWLIT
RYDEVKALLSDRRLGLSDPKPERAAKSTARITMMALMAGDDYDREATEHPQMRELLVP
RFSTRRMRVMKARIEQHVDELLDQLAASVAPVDLHRALSFPLPTMVVCDLLGVPLADR
ERIGQWARGTFDQSDSLHSVNTFQQVVDYMMELVQRKRTEPGDDILSELIAEKDGTLS
DEYIAHLGCAVLLFGYETTIVRIDMGVLLMLRNPAQRALLAENPALAPAAVEEILRLA
VGGKGSNALIPRYAHSDITVGETVIRTGDAVMLAIGAANIDGHAFPHADLFDLSREKP
KAHMAFGHGTRHCIGRVLARIELTAVFERLFRRLPNLQLAVPEESLRWQEHRITGGFD
EIPVTF

CYP162A1 Streptomyces tendae nikkomycin

MRVDLSDPLLYRDSDPEPVWSRLRAEHPVYRNERANGEHFWAVM
THGLCTDMLTDPRVFSSQNGMRLDSDPQVLAAAAGKMLNITDPPRHDKIRKVVSSAFT
PRMVSRLEATMRETAAKAIDEALAAGECEFTRVAQKLPVSVICDMLGVAPADWDFMVE
RTRFAWSSTALDEAEEARKVRAHTEILLHFQDLAAERRREPKDDLMSALVCGEIDGAP
LTDQEILYNCDALVSGGNETTRHATVGGLLALIDNPDQWHRLRDEPALMPSAIQEIVR
YTSPVMHALRTATEDVEFGGERISAGDHVVAWLPSANRDEKVFDDPDRFDIEREPNRH
LGFIQGNHYCIGSSLAKLELTVMFEELLARVEVAELAGQVRRLRSNLLWGFDSLPVKF
VPRA

CYP162A2 Streptomyces ansochromogenes

MRVDLSDPLLYRDSDPAPVWSRLRAEHPVHRNERANGEHFWAVM
THGLCTDMLTDPRVFSSRNGMRLDSDPKVLAAAAGKMLNITDPPRHDKIRKVVSSAFT
PRMVSRLEATMRKTAAEAIDEALAAGECEFTRVAQKLPVSVICDMLGVAPADWDFMVE
RTRFAWSSTALDEAEEARKIRAHTEILLHFQDLAAQRRREPQDDLMSALVCGEIDGAP
LTDQEILYNCDALVSGGNETTRHATVGGLLALIDNPDQWHRLRDEPALMPSAIQEIVR
YTSPVMHALRTATEDVEFGGELISAGDHVVAWLPSANRDEKVFDDPDRFDIGREPNRH
LGFIQGNHYCIGSSLAKLELTVMFEELLARVEIAELAGQVRRLRSNLLWGFDSLPVTF
VPRA

CYP162B1 Saccharopolyspora erythraea NRRL23338

VIQAPTVDLTDPELFSSNRFWEVLAWLRANDPVHWHPDAEGSGFWVVTRYDDVTAVYADA
ETFSSRFGMRLGSNDDAVSAVSQRMLIVSDPPDHTHLKRVLSKTFGGSEMSRLEGLVRDV
VREVVADAVEAGETDFLDVAKLIPNYVVCAVMDLPREDWAWVGRTTTDAFEGEDEETRSG
AHGEIFLYFDDLLRQRRGGSGEDFISRVARDRRATDVPDQDRLLTDEEIVFNCNGVLAGA
NETTRYSTAGGVLALAENPDQWRKLREGGAAAIPAAVEEILRWTVPGVHALRTATRPATI
RGQSIGVGDRVTIWNVSANRDEAVFADADSFVVDRSPNRHITFGAGRHLCLGARLARLEL
SAFLSELLDRVEEIELCGEPQYNASNFTWGLRELPVRLVRKQKVP

CYP162C1 SGR582 Streptomyces griseus

42% to CYP162A1 Streptomyces tendae nikkomycin
43% to CYP162A2 Streptomyces ansochromogenes
MSGEAGGCPAGTARGPDLTDPATYRDADYFAQWQRARRDHPVVRLESPRFGAFWSVTAHAAARQVLERPESFTSTRGMRLGGEPAAVSAASGRMLVVSDGPAHTRLRSAHAPWFAGQAVSRLKDALRSRLDALLADLADGSPVDVPARLARPLPTWLVCGMLGVPEEDWEELA
LLAAAAFDETETSTASARRAASAGVFAYFAELLEKRRADPGDDLVSALVHQPGGDRLTDEEILLTCDGLVNGGLGTTRHAVSGAVLAFAAHPRQWERLRADRGLVPTAVEEILRWVSPPLHIMRTATEDVLLGGARIRAGERVVLWIPSCNRDESVFAEPDAFRVDRRPNPHLGLGG
GPHYCIGASLARLELRTLLRALLDHVARFESDPVLTRTPSTFLHGLDRLEVTLIPAADAAACSPAESEDP

CYP163A1 Streptomyces spheroides novobiocin

MSTRPTVSPSELEQIDLASPVLHAEYELDEIFRHLRADEPVYWQ
QPRNEQPGFWVISRHADVNEVYKDKEHFTTEHGNALATLLTGGDSASGAMLAVTDGVR
HHQVRNVLSRGFSARMLDLIAHTLQETVDGLLLAALERGECDAAQDIAADVPLGAICD
LLEIPHADRKYLLGLTSHAWSTDYADEPPEESWVAKNEILLYFSKLLKERRGGVREDM
VSLLANCRIDGDPLKAAEQMANCYGLMIGGDETGRHAITGTILALIQNPDQWRALKNG
DVDLNTATEEALRWTVPSLHGGRKATGDVVINGRRINAGDVVSVWISSANRDETVFDA
PDEFNLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYS
SILHGMSSLPIRITG

CYP163A2 Streptomyces roseochromogenes subsp. oscitans

MSTRPTVSPDELEQIDLASPILHAEYELGEVFRYLRANRPMYWQ
QPRGEQPGFWVISRYADVNEVYKDKAHFTTEHGNALATLLTGGDSASGAMLAVTDGVR
HHQVRNLLSKGFSPQMLDLIANSLRETVDGLLLAALDRGECDAAQDIAANVPLGAICD
LLEIPQTDRKYLLGLTAHAWSTDYADETPEEGWVAKNEILLYFSKLLKERRGGDRDDM
VSLLANCRIDGHPLNAAEQVANCYGLMIGGDETGRHAITGTILALIENPDQWRALKNG
DVDLKTATEEALRWTVPSLHGGRKATGDVVINGQQIKAGDVVSVWISSANRDEAIFDA
ADEFKLARTPNKHFTFAYGSHYCLGHYLGRMEVYAVLDGLRRLVGDLEQIGEERWIYS
SILHGMSSLPIRITV

CYP163A3 Streptomyces antibioticus

MNPRPMLSPDVLEDIDLNDRQLHADYDLSEVWRYLRAERPFYYQ
TARGSQPGFWVVTRHADCTAVYKDKTNFTAERGNVLPTLLAGGDSASRTMLALTDGDR
HTQVRNLLMKAFSPKMLSNIGQSLRTTVDGLLRDAIEKGECDFARDVSGKVPLVAICD
LLAVPQEDREYLLSLTAHALSADEADATAEDNWTAKNEILLYFADLAESRRSSGHNDV
VSLLATSSIEGEPLSDGELMANCYGLMIGGDETGRHAITGGLRALIHHPDQWRMLRNG
EADLQTATEEVLRWTVPSLHGARTATADVVVNGKQQIRAGEIVSVWFASANRDEEVFR
DADRFDLNRTPNKHLTFAFGPHFCLGHYLARMEVEAILDGLRRMVDDIQQTGPEKLIY
SSILQGISSFPALLKPDRRVPPQT

CYP163B1 Salinispora tropica (marine actinomycete)

MTAADTGRVGSGESQTPAHTVDLADPATFANHDLTGFWQQLRDEEPIHWNPPTAGRRGFW
VVSRYADILDVYRDDVTFTSERGNVLVTLLAGGDAGAGRMLAVTDGPRHAELRKLLLRAL
GPRVLAPVCAAVRTNTRQMIREAVTKGECDFASDIASRIPMMTISNLLGVPDADRAFLLS
LTKTALSADDESISETESAMARNEILLYFQDLMEFRRDHPGEDVVSMLVNSSIDGAPLSD
DDIVLNCYSLIIGGDETSRLTMIDSVNTLAAHPQQWRRLKDGQCEIDKAVDEVLRWASPS
MHFGRVAARDTILHGVRIRADDIVTLWHASGNRDERVFHRPEVFDLGRTPNRHLSFGHGP
HYCIGSYLAKVEISELLIALRDLTSGFETTGEPQRIRSNLLTGFATMPVRFVPDRAGLAR
DALDG

CYP163B2 SGR3267 Streptomyces griseus

MTTATSTLHGVDLTDPQTFLDRKDDLVGLWQEFRSHSPVHWHPVEGRQVPGFWVLSRYRDVMEVYRDNKRFTSERGNVLATLLEGGDSAAGQMLAVTDGRRHRELRNLLLKAFSPRLLASVVEGVRRRADRLVREAVGRGSCDFAQDVAEHIPMATIADLLGAPAADRDYLLSL
TKQALSAEEAGQSAEEAVVARNELLYYFSELAEIRREDPRDDVVSVLATATVDGKPLTEQEIVFNCYSVIIGGDETSRLSMICAVHELMEHPDQWRRLVSGEVSVDSAVEEVLRWVTPAMHFGRRALTDVEIGGRTIRAGDVVTLWNSSANYDETVFDRPEEFDLARTPNKHVSFGY
GPHFCLGAYLGRGEIHALLTALRTHVAAMEPTAPARPIHSNFLHGYSSLPVSLRPVTGDRT

CYP163C1 SBI_8210 Streptomyces bingchengensis

49% to CYP163A3 Streptomyces antibioticus
MDTRRALPPQPLDQLDLADPLLHAHHDLGPLWRRLRAEAPVHWQPETARG
PGFWAVSGYADVVSVLGDSETFTSERGNVLDTLLAGGDSAAGQMLAVTDG
RPHQALRSALLKPFSPRSLDVVVDSVRRGTRALVEEAVERGEVDFAADVA
AHIPLAAICDLLGVPAAERQHIIDLTSGALSSADGAPTEEATWASRNGLL
LYFSELAAERRAKPYDDVVSLLVTKEIDGRPLTHEEIVFNCYSIIMGGHE
TTRFAMVGGLRALMEHEDQWQALKSGRVATASAVEEVLRWTTPALHSGRT
ATRDVLLDDRFVEAGDIVVTWLASANRDERVFDRPDEFDLSRTPNKHLSF
AHGSHFCLGAFLARAELTALLESARDLVDKAEPAGPPRYVYSNFLSGMSA
LPVSLTPSCRVLAGPVAWEGPTAGLTVGNMTHTPAAVGAEAVSAVVCGMV
RLVAPRKLDQVELDHRLVGDLGFHSLVLAELGYNLEDLYGLRALTPEETM
KLERVKDVIEFVSTEVASGRAQLPDEEELSDLFARYGADAPTA

CYP164A1 Mycobacterium leprae cosmid B1788

1 MRTCVPTRTC VYAFIEYLSH NRPMGTNPPS LVEAQMLLLR LIDPGTRADP FPVYRALIDY
61 GPMQLPGMPL TVFSSFSDCD EALRHPLSAS DRLKATLAQQ AIAAGAEPRP FYASSFMFLD
121 PPDHTRLRKL VSKAFAPKVV QALEGDIAAL VDSLLDKGAA AGQFDVIADL AFPLAVAVIC
181 RLLGVPYEDA PEFGRVSALL VQSVDPFITI TGEPPEATEE RLRAGVWLRD YLEQLVKCRR
241 GTPGEDLISR LIELDESGDQ LTEEEIIATC GLLLVAGHET TVNLIANAVL AMLRNPSQWK
301 ALSSNPQRAP LVVEETLRYD PAIHLIGRVA AKDMTIGQTT LTEGDTMVLL LAAANRDPAV
361 YSRPDEFDPD RPSSRHLAFA VGSHFCLGAA LARLEATVTL SAISARFPQV QLAGELVYKP
421 NVAMRGMSAL PVQV

CYP164A2 Mycobacterium smegmatis

MHNGWMSTAATAQEAQGLLLQLLDPATRADPYPIYDRIRRGGPLALPEAN
LAVFSSFSDCDDVLRHPSSCSDRTKSTIFQRQLAAETQPRPQGPASFLFL
DPPDHTRLRGLVSKAFAPRVIKRLEPEITALVDQLLDAVDGPEFNLIDNL
AYPLPVAVICRLLGVPIEDEPKFSRASALLAAALDPFLALTGETSDLFDE
QMKAGMWLRDYLRALIDERRRTPGEDLMSGLVAVEESGDQLTEDEIIATC
NLLLIAGHETTVNLIANAALAMLRTPGQWAALAADGSRASAVIEETMRYD
PPVQLVSRYAGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPD
RAQIRHLGFGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR
NLTLRGMSTLSIAV

CYP164A3 Mycobacterium marinum MM5268

MLRGPVTAAT HFDHTFFMRR HNVSMTTRPI EPIEFTEQVE PQAFLFQLLD PAIRADPYPL
CARLRDHGPL HLPEANFVLF SSFGDCDEVL RHPSSCSDQT KSTVAQRRVE EEPALGRDFP
PGFLFLDPPD HTRLRKLVSK AFAPKVVNAL RPEISSLVDG LLDRIAEQGR FDVVSDFAYP
LPVAVICRLL GVPLEDEPQF SQASALLAQA LDPFFAFTGQ NAENLNDSLE AGQWLRGYLR
DLIALRRSQP GEDLMSGLVA VEESGDQLTE DEIVSTCVLL LVAGHETTVN LIGNAILAML
RDRRQWAQLG ADPDRAAAVV EETMRYDPPV QLIGRIAGAD MVIGDVEVAK GDVMMMLVAA
AHRDPAEYDR PEEFDPDRGA LRHLGFGRGA HYCLGAPLAR LEASVALSAI AARFPQARLD
GEPQYKTNVT LRGLESMTVA LS*

CYP164A3P Mycobacterium ulcerans

MLRGPVTAATHFDHTFFMRRHNVSMTTRPIEPIEFTEQVEPQAFLFQLLDPAIRADPYPL
CARLREHGRLHLPEANFVLFSSFGDCDEVLRHPSSCSDQTKSTVAQRRVEEEPALGRDFP
PGFLFLDPPDHTRLRKLVSKAFAPKVVNALRPEISSLVDGLLDRIAEQGRFDVVSDFAYP
LPVAVICRLLGVPLEDEPQFSQASALLAQALDPFFAFTGQNAENLNDSLEAGAVAARIPA
*MTRWKRGQWLHGYLRDLIALRRSQPGEDLMSGLVAVEESGDQLTEDEIVSTCVLLLVAG
HETTVNLIGNAILAMLRDRRQWARLGADPDLAAAVVEETMRYDPPVQLIGRIAGADMVIG
DVEVTKGDVMMMLVAAAHRDPAEYDRPEEFDPDRGPLRHLGFGRGAHYCLGVPLARLEAA
VALSAIAARFPQARLDGEPQYKTNVTLRGLESMTVALS

CYP164A4 Mycobacterium vanbaalenii PYR-1

MRLLHLHALHPRVSAPLVQGQGDAVRDAVHDPQRAVRHPPRRRHPRRHPRGPVRRAARARPRPVLRQGVA
SAGVFDLHPFRLVHNKSMTTAAEPQSLLLQMLAPEVRADPYPVYAQILAHGPMQLPGNNLTVFSSYADCD
EVLRHPDASSDRLKSTAAQRAIADGAEARPFGPPGFLFLDPPDHTRLRWLVSKAFVPKVVKALEPDIVTM
VDGLLREAEAGATFEAIGGLAYPLPVAVICRLLGVPLEDEPQFSAASALLAQSLDPFISVTGSAGSGFEE
RMQAARWLRGYLRELIARRRRDPGEDLMSGLIHVEESGDQLTEDEIVATCNLLLVAGHETTVNLIANAIL
ALLRNDGQWAALAADPGRAAAVIEETLRHDPPVQLVGRIAGQDMTIGGERSDGGNVAGGVTVPKGDNILL
LTAAAHRDPDHVDRPDEFDPDRPVIRHLGFGKGAHFCLGAPLARLEATLALTALTSRFPDAKLAAEPVYK
PNVTLRGMSELSITLA

CYP164A5P Mycobacterium leprae cosmid B1450

AVDALLCFLSPPGLAGPRFAVTDVEIGQHTVVAGQTVRLYLASANHDPQRFNCTDELEPTRPAPHTA

CYP164B1 Streptomyces peucetius

MPNLMNLDAPDHTRLRRLAGKAFKPRLVQQWRPRIEEIVRELLTDIAAGENTADLVSAFA
YPLPVRVICDMLGVPREDHPVFEKWARSIAYTVDPQLVPGRLSTEVVQEVEEARAGFVGY
FGRLIAERRHTPRADVLSELISAEEQGDQLTESELIITCILLLVAGHETTANLILNGILG
LLRHPGQLRLLRERPELAEAAVEEVLRYDAPAQMITRIAREPFTIGDTPVTPGTPLLVLL
AAANRDPDVHRDPDTFDISRGDPGHLGFAAGPHFCLGSVLARLEGSIALNAFAQAFVEPR
LDAESLRYRPHVAVRGPDRMRVSFKEIRVDAVRVTGTSERSVASRG*

CYP165A1 Amycolatopsis mediterranei

MFEESNALRGTEIHRRDRFAPGPELRSLMGEGTMSILQPPDSPG
GRTGWLATGHDEVRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMVTS
AFTVRRMQDFRPRIEQIVQASLDAIEAAGGPVDFVPRFAWSVATTVTCDFLGIPRDDQ
ADLSRALHASRSERSGKRRVAAGNKYWTYMTEIAARARRDPGDDMFGAVVRDHGDAIT
DAELLGVAAFVMGAGGDQVARFLAAGAWLMVEHPDQFALLREKPDTVPDWLNEVERYL
TSDEKTTPRIAQEDVRIGDQLVKAGDAVTCSLLAANRRKFPAPEDEFDITRERPVHVT
FGHGIHHCLGRPLAEMVFRAAIPALAQRFPKLRLAEPDREIKLGPPPFDVEALLLEW

CYP165A2 Amycolatopsis orientalis cosmid PCZA363.

MFAENNAVRGTEIHRREQFDPGPELRSLMAEGPMSILEADDPAE
GRTGWLATGYDEIRQVLGSDKFSAKLLYGGTVAGRIWPGFLNQYDPPEHTRLRRMLTS
AFTVRRMQGFRPRIELIVEATLDDIEATGGPVDFVPRFAWPIATTVTCDFIGIPRDDQ
ADLSRALLASRSERTGKRRVAAGNKFWTYMSQVAAQARRDPGDNMFGAVVREHGDAIT
DAELLGVAAFIIGAAGDQVARFLAAGAWLIAEHPEQFAVLRDKPDTIPDWLNEVARYL
TSDEKTTPRIALEDVYIGDQLVKAGDAVTCSLLAANRRNFPAPEDQFDITRERPAHVT
FGHGIHHCLGRPLAEMVFRTAITALTRRFPTLRLAEPGREIKLGPPPFDVEVLLLDW

CYP165A3 Amycolatopsis orientalis

MFEEKNALRGTEIHRRERFDPGPELRALMAEGRMSVMESEESPG
GRTGWLATGYEETRQVLGSDKFSAKLLFGGTAAGRIWPGFLNQYDPPEHTRLRRMVAS
AFTVRRMRDFRPRIEAVVKATLDDIEATGGPVDFVPRFAWPIATTVICDFLGIPRDDQ
AELSRVLHASRSERSGKRRVAAGNKYWTYMGQVAAKTRRDPGDDMFGAVVREHGDDIT
DAELLGVAAFVMGASGDQVARFLSAGAWLMVEHPEQFAVLRDDPDSVPDWLNEVARYL
TSDEKTTPRIALEDVRIGDQLVKKGDAVTCSLLASNRHRFPDPEDRFDITREKPSHVT
FGHGIHHCLGRPLAEMVFRTAIPALAHRFPTLRLAEPDREIKLGPPPFDVEALLLDW

CYP165A4 Streptomcyes toyocaensis strain NRRL 15009

MFEEINVVRASQLHRRDRFDPVPELHSLMKEGGLTVLGTEDSTE
GRTAWLATGIDEVRQVLGSDKFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVVP
AFSHRRMQKFRPRVEQIVQDSLDTIESLGGPVDFVPHFGWAIATPATCDFLGIPRDDQ
ADLARILLASRTDRSDKRRTAAGNKFMTYMKQHVAQSRRGSGDDLFGIVGRENGDAIT
DAELTGVAAFVMGAAADQVARLLAAGAWLMVEQPAQFALLREKPETVPEWLDETMRYL
TTDEKTHPRVATQDVRIGNQLVKAGDTVTCSLLAANRPNYPSAEDEFDITREKAEHLA
FGHGIHHCLGRAMAELMFKVSIPALAHRFPTLRLADPQREITLGPPPFDVEALLLDW

CYP165A5 Actinomadura sp. ATCC 39727

MEVFEELNVVLPGELHWRDRFDPVPQLRSFMAEGPMTELGAEEG
PGGRTAWLATGFDEVRQVLGSDKFSSRLLYGGTAAGIVFPGFITQYDPPEHTRLRRVV
SPAFTVRRMERFRPQVDQVVEDCLDAIESIGGPLDFVPHFGWSIATTATCDFLGIPRD
DQAELSRSLHASRSQRAASRRGAAGNKFMTYMGQVVARTRRDPGDDMLSVVVREHGDE
ITDAELTGLAAFVMGAGGDQVARFLAAGAWLMAEVPEQFALLRDKPDVVPDWLEEMVR
YLTIDEKLTPRIALEDVRIGDRIVKAGDTVTCSLLGANRRHFPGPDDQFDLTRDRAPN
VAFGHGIHHCLGRPLAELIFRSAIPALARRFPALRLAEPEQEIRLGPPPFDVKALLLDW

CYP165A6 Actinoplanes teichomyceticus Genpept CAG105017

GenEMBL AJ632270 CDS 47098..48273   teicoplanin gene cluster
80% to CYP165A4 Streptomcyes toyocaensis strain NRRL 15009
MFEEINVVRAAELHRRDRFDPVPQLRSLMAEGPLTTLGTEESPG
GRTAWLATGYDEIRQVLSSDDFSARLLYGGTAAGITWPGFLTQYDPPEHTRLRRMVAP
AFAVRRMQKFQPQVERVVQDSLDAIEALGGPVDFVPRFGWSVATTATCDFLGIPRDDQ
ADLARSLHASRTERSGKRRTAAGNKFMTYMNKMTARTRRDPGDDMFGVVVREYGDEIT
DAELTGVAAFVMGAGADQVARFLAAGAWLMADDPEQFALLREKPDTVPDWLDEVIRYL
TTDEKTHPRVATDDVRIGDHLIKAGDTVTCSLLAANRRNFPRPEDRFDITRVRPEHLA
FGHGIHHCLGRSLAELVFRTAIPALAHRFPTLRLAEPHREIRLGPPPFDVEALLLDW

CYP165B1 Amycolatopsis mediterranei 9.9kB DNA

MNDDDPRPLHIRRQGLDPADELLAAGSLTRVTIGSGADAETHWM
ATAHALVRQVMGDHQRFSTRRRWDPRDEIGGTGTFRPRELVGNLMDYDPPEHTRLRQK
LTPGFTLRKMQRLQPYIEQIVNERLDEMARAGSPADLVAFVADKVPGAVLCELIGVPR
DDRATFMQLCHAHLDASRSQKRRAAAGEAFSRYLLAMIARERKDPGEGLIGAVVAEYG
DEATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIDALRGGEQPAQRAVDEL
IRYLTVPYGPTPRIAKQDVTVGDQVIKAGESVICSLPAANRDPALVPDADRLDVTRDP
VPHVAFGHGIHHCLGAALARLELRTVFTALWRRFPDLRLADPAQETKFRLTTPAYGLT
ELMVAW

CYP165B2 Amycolatopsis orientalis cosmid PCZA363.

MVAQELSQSGDDDPRPLHIRRQDLDPADELLAAGALTRVTVGSG
ADAETSWMATTHGAVRQVMGDHKSFSTRRRWHQRDEIGGTGIFRPRELVGNLMDYDPP
EHTRLRQKLTPGFTLRKMQRMQPYIEQIVADRLDAMEQAGSPADLIEFVADEVPGAVL
CELIGVPRDDRAMFMQLCHGHLDASRSQKRRAAAGEAFSRYLLAMIARERKDPGEGLI
GAVIAEYGDEATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIAAFQGDEQS
AQRAVDELIRYLTVPYAPTPRIAMQDVIVASQMIKKGESVICSLPAANRDPALVPDPN
RLDVTREPVPHVAFGHGVHHCLGAALSRLELRTVYTALWQRFPTLRLADPAKETNFRL
TTPAYGVTSLLVAW

CYP165B3 Amycolatopsis orientalis

MSEDDPRPLHIRRQGLDPADELLAAGALTRVTIGSGADAETHWM
ATAHAVVRQVMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRK
LTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPR
DDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYG
DDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQRAVDEL
IRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREP
IPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLT
ELMVAW

CYP165B4 Streptomcyes toyocaensis strain NRRL 15009

MSGDDRPPIHTLRQGFDPADELRAAGELTRVRLGSGADAEHTWL
ATGHDVVRQVLGDHTRFSTRRRFDRNDEIGGKGVFRPRELVGNLMDYDPPEHTRLRRL
LAPGFTHRKIRRMAPYIEQIVTERLDEMEREGSPADLIELFADEVPGPVLCELLGVPR
DDRAMFLQLCHRHLDASLSGRRRAAAGEAFSRYLVTMVARERKDPGDGLIGMVVAEHG
DTVTDEELRGVCVQMMLAGDDNISGMIGLGVLALLRNPEQIAALRGDVPAAERAVDEL
IRYLTVPYAPTPRTAIEDSTVGDQVIKAGETVLCSLPTANRDPALLPDADRLDVTREA
VPHVAFGHGVHHCLGAALARLELRIAYTALWRRFPDLRLADPDGATEFRLSTPAYGIS
RLMVTW

CYP165B5 Streptomyces lavendulae

MPQQAQRQAPQQQPRAQQAYPELLYTRRTRFDPADDLRAAPPLS
RYVIGPNESDEWVWLATGYTEVRRILGDHTNFSTRRRWGAEGPNWRPPELVGHLMDYD
PPEHTRLRQMLTPEFTVRRLRRLEPDITAIIEEHLDTVEATGPGADLMPLFAQPVPGE
VLCELIGVPRDDRPEFLRHCHRHLDFSRSRKVRAADGAAFSRYLVSMVARQRKDPDDG
FIGALVREHGDDFTDEEMRGVCVLLILAGIDNIEGMIGLGVLAMLENPDQLPLLLGER
DSTGGPGAGKGDGGRLASDRALDELIRYMSVANAPTPRTAVNDVRIGDQLIKAGETVI
CSLTMANRDPALTDGPDRLDLAREPVAHVAFGHGVHHCLGAALARTELRIAYKALWRR
FPELRLAVPVEEVRFYNRALAHGVHRLPVAW

CYP165B6 Actinomadura sp. ATCC 39727

MSGDGARPLHTRRQDLDPADELRAAGTLTRITIGSGADAETTWL
ATGYTVVRQVLGDHRRFSTRRRWNERDEIGGRGNFRPRELVGNLMDYDPPEHTRLRQK
LTPGFTLRRIRRLKPYIEQIVTERLDALERAGPPADLVELVADEVPGAVLCELIGVPR
DDRAMFMQLCHGHLDASRSQKRRAAAGAAFSRYLLAMIARERKDPGEGLLGAVLAEYG
DTATDEELRGFCVQVMLAGDDNISGMIGLGVLALLRHPEQIAALQGDDQSADRAVDEL
IRYLTVPYAPTPRVAMEDVTIGGQVIKEGETVSCSLPMANRDPALLPDAGRLDVRREP
VPHVAFGHGVHHCLGAALARLELRTVYTALWRRFPTLRLADPDREPSFRLTTPAYGLT
SLMVAW

CYP165B7 Actinoplanes teichomyceticus Genpept CAG105019

GenEMBL AJ632270 CDS 49590..50636teicoplanin gene cluster82% to CYP165B4 Streptomcyes toyocaensis strain NRRL 15009
MRQVLGDHKRFSTRRRFDRRDEIGGTGVFRPRELVGNLMDYDPP
EHTRLRHLLTPGFTQRRMRRLAPRIEEIVTDRLDAMEQAGPPADLIELFADEVPGAVL
CELIGVPRDDQAMFLQLCHRHLDASLSARKRAAAGEAFARYLVAMMARERKDPGDGFI
GSIVAEHGDTITDEELRGVCVQLMLAGDDNVSGMIGLGVLALLRHPEQIAALRGDDQS
ADRAVDELIRYLTVPYAPTPRTAVEDVMVADQVIKEGETVLCSLPMANRDRALLPDAD
RLDVTRTPVPHVAFGHGIHHCLGAALTRLQLRIAYTALWRRFPALQLADPAQEIMFRT
STPAYGLTSLLVAW

CYP165C1 Amycolatopsis mediterranei 9.9kB DNA

MGHDIGQLAPLLPEPANFQLRTNCDPHADNFDLRAHGPLVRIAG
DSSAQLGREYVWQAHGYDVVRRILGDHENFTTRPQFTQAKSGAHVEAQFVGQISTYDP
PEHTRLRKMLTPEFTVRRIRRMEPAIQALVDDRLDRVAAEGPPADLQALFADPVGALA
LCELLGIPRDDQREFVRRIRRNTDLSRGLKARAADSAAFNRYLDNLIARQRRDADDGF
LGMIVREHGDTVTDEELKGLCTALILGGVETVAGMIGFGVLALLENPGQVPLLFAGPE
QADRVVNELLRYLSPVQAPNPSLAVKDVIIDGQLIKAGDYVLCSVLMANRDEALTPNP
NVFDANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQALWQRFPGLRLAVPIAEVKYR
SAFVDCPDRVPVTW

CYP165C2 Amycolatopsis orientalis hypothetical

ISTYDPPEHTRLRKMLTPEFTVRRIRRMEPAIQSLVDDRLDMLE
AEGSPADLQGLFADPVGAHALCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAA
FNRYLDNLIARQRADPDDGLLGTIVREHGGNVTDEELRGLCTALILGGVETVAGMIGF
GVLALLQHPGQIPLLFEGPEKADRVVNELVRYLSPVQAPNPRLAIKDVVVDGQLIKAG
DYVLCSVLMANRDEALTPDPNVFDANRTAVSDVGFGHGIHYCVGAALARSMLRTAYQT
LWRRFPGLRLAVPVEEVKYRSAFVDCPDQVPVTW

CYP165C3 Amycolatopsis orientalis cosmid PCZA363.

MAHGIDQHGIDQHGIDQHGIDQHGIDQHGIDQHGIDQHSIDQHG
IDQHGMEQVAPLLQEPANFQMRTGCDPHEENFDLRAHGPLVRLVGDSSTQLGRDYVWQ
AHGYDVVRKILGDHENFTTRPQFTHAKSDAHVEAQFVGQISTYDPPEHTRLRKMLT
PEFTVRRIRRMEPAIQGLIDDRLDMVEAEGPPADLQGLFADPVGALALCELLGIPRDD
QREFVRRIRRNTDLSRGLKARAADSAAFNRYLDNLISRQRKDPDEGFLGMIVREHGDN
VTDEELKGLCTALILGGVETVAGMIGFGVLALLENPDQIQLLFAGPEKADRVVNELVR
YLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSVLMANRDEALTPNPNVLDANRAAVS
DVGFGHGIHYCVGAALARSMLRMAYQTLWQRFPGLRLAVPIAEVKYRSAFVDCPDQVP
VTW

CYP165C4 Amycolatopsis orientalis

MGHDIDQVAPLLREPANFQLRTNCDPHEDNFGLRAHGPLVRIVG
ESSTQLGRDFVWQAHGYEVVRRILGDHEHFTTRPQFTQSKSGAHVEAQFVGQISTYDP
PEHTRLRKMLTPEFTVRRIRRMEPAIQSLIDDRLDLLEAEGPSADLQGLFADPVGAHA
LCELLGIPRDDQREFVRRIRRNADLSRGLKARAADSAAFNRYLDNLLARQRADPDDGL
LGMIVRDHGDNVTDEELKGLCTALILGGVETVAGMIGFGVLALLDNPGQIELLFESPE
KAERVVNELVRYLSPVQAPNPRLAIKDVVIDGQLIKAGDYVLCSILMANRDEALTPDP
DVLDANRAAVSDVGFGHGIHYCVGAALARSMLRMAYQTLWRRFPGLRLAVPIEEVKYR
SAFVDCPDQVPVTW

CYP165C5 Streptomcyes toyocaensis strain NRRL 15009

MRRTLCDPHEDMFALRAHGPLIRIEGNASDQMSTDYVWQAMGYD
VVRKILGDHENFTTRLRLTDAQPLSGEGVSVPPELAGQISIYDPPEHTRLRRMLTPEF
TVRRIRRLEPAIEGIIEEHLDALEGAGPPADLQVLFADPVGGETLCELLGVPRDDRNE
FIRRVRQNVDLSRGYKARAADSAAFNRYLMTLITRQRKDPDEGFLGMLVREHGDRITD
EELKGVCTALILGGVESVAGMIGFGVLALLEHPDQRRLLFGSREEADRLVNELLRFLS
AVQQPTPRMAVRDVVVEGQLIKAGEYVLCSILMANRDEGLTSDSHLLDANREPLPHVA
FGHGIHHCIGAAVARAVLRITYQSLWRRFPRLSLAVPAGEVKFRNAFIDSPDRLPVTW

CYP165C6 Actinomadura sp. ATCC 39727

MRIDSEWSFDPGMDDDIDAGAPVLQPTANYMMRTHCDPHEDMFA
LRAHGPLVRIGGDAATQLRVDYVWQALGYDVVRRILGDHENFTTRPRWSSAPSIAGEP
IPPNLVGQLSVYDPPEHTRLRGMLTPEFTARRIRRLEPAMQDLIDDRIDELEAAGPPA
DVQALFADPVGGGVLCELLGIPRDDRIEFIRRVRQNVDLSRGFKARAADSAAFNRYLN
GLIIRQRKDPDEGFIGMLVREHGDDVTDEELKGVLTALILGGVETVAGSIGFGVLALL
DHPDQRQSLFAGREEADRVVGELLRFLSPVQQPNPRLAVRDVVVDGQLIKAGDYVLCS
ILMANRDEALTPNANVLDVRRDCGSHVGFGHGIHYCIGAAIARTLLRMAYQSLWRRFP
GLRLAVSAEEVKFRNAFIDCPDELPVTW

CYP165C7 Actinoplanes teichomyceticus Genpept CAG105021

GenEMBL AJ632270 CDS 52502..53746  teicoplanin gene cluster
78% to CYP165C6 Actinomadura sp. ATCC 39727
MFTGMDHDIDEVAPVVEPTANYMRRTVCDPHEDMFALRAHGPLI
RIGGDAAVQMGADYLWQAMGYDVVRQILGDHENFTTRLRLTASEPISGEGATKPQELV
GQISTYDPPEHTRLRRMLTPEFTVRRVRRLEPAIQELIDDRIDAMEAAGPPVDVQTVF
ADPVGGGALCELLGIPRDDRNQFMRRVRQNVDLSRGYKARAADSAAFNRYLQSLITRQ
RKDPDEGFLGMLVRDHGDDITDEELKGVCTALLLGGVETVAGMLGFGVLALLDHPDQR
RLLFAGREEADRLVNELLRYLSAVQQPTPRMAVKDVVVDGQQIRAGEYVLCSILMANR
DEALTPHPNVLDAEREPAPHIGFGHGIHHCIGAAVARTVLRMAYQTLWRRLPGLRLAI
PAGQVKLRNAFIDSPDQLPVTW

CYP165D1 Streptomcyes toyocaensis strain NRRL 15009

MALPLPHRRHRLDPVPEFHDLQNEGPLHEYDTEPGMDGRKQWLV
TGYHEVRDILADPERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDLEDVGSPVDFVRYAAWPIPALIACEFLDVPRDDRAELSRM
IRESRESRLPRQRTSSGMGVVNYTQKLAARKRLDPGEGMIGVIVREHGAEVSDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREHPELVDGATEELLRHASIVEAP
APRVALEDVSVAGRDIRAGDVLTCSMMAVNRPQGEHFDITRENPKHMAFGYGIHHCLG
APLARLQLRVALPAVLRRFPSLRLAVPEEDLRFKPGRPAPFAVEELPVEW

CYP165D2 Actinomadura sp. ATCC 39727

MVVPLPHQRLRLDPVPALFDLQEDGPLHEYDTEPGLDGHKQWLV
TGYGEIREILADANRFSSMRPVEDEAERAWLPGILQSYDAPDHTRLRRTVTRANTARR
IESLRPVVEETVEDCLADLESMGSPVDFVRNAAWPIPALIACDFLGVPRDDQAELSRM
FRDSRESRVPRQRNVSGLGIVDYARKLAARERLDPGTGMIGGIVREHGGEVTDEELAG
LVEGIMIGAVEQMASQLAIAVLLLVTHPDQMALLRERPELADSAAEEVFRYASIVETP
SPRTALVDTRLAGRDIHAGDVLTCSILAGNRAREDRFDLTRGNPEHLAFGHGVHFCLG
APLARLQAQVALPALVRRFPSLRLAVPAEDLRFKPGKPAPFAVEELPVEW

CYP165D3 Actinoplanes teichomyceticus Genpept CAG105018

GenEMBL AJ632270 CDS 48296..49450  teicoplanin gene cluster
86% to CYP165D1, 75% to CYP165D2
MALPLPHQRLRLDPVPEFEELQKAGPLHEYDTEPGMDGRKQWLV
TGHDEVRAILADHERFSSMRPVDDEADRALLPGILQAYDPPDHTRLRRTVAPAYSARR
MERLRPRIEEIVEECLDDFESVGAPVDFVRHAAWPIPAYIACEFLGVPRDDQAELSRM
IRESRESRLPRQRTLSGLGIVNYTKRLTSGKRRDPGDGMIGVIVREHGAEISDEELAG
LAEGNLIMAAEQMAAQLAVAVLLLVTHPDQMALLREKPELIDSATEEVLRHASIVEAP
APRVALADVRMAGRDIHAGDVLTCSMLATNRAPGDRFDITREKATHMAFGHGIHHCIG
APLARLQLRVALPAVVGRFPSLRLAVPEEDLRFKPGRPAPFAVEELPLEW

CYP165E1 Streptomyces lavendulae

MASRDVPVYNRRDRLDPVPELVELRNRCPVLRTELHGGPSSQVV
GWLVTGIDESREVLSDQHRFTMLPPADTEAQSRRLQNIGNPLHYDPPEHTRLRKMLNP
EFTMRRLRRLQPRIDAVVEECLDAMEQAGAPADLMQHFAWQIPGHTACELLGVPRDDR
AELSRHLDITRDDGRGRARQMAAGRAYRAYFHQLTARQRRDPGDDLLGMLVREYGDEI
TDEELEGLAASLTSAGIENVASMLGLGTLVLLEHPDQLAELREKPELIDRAVEELLRH
VSVIPTLSPRTALEDVPLGGHVVPKGERVICSAFAANRIATPGDDLEDGFDITREPAP
HMAFGHGVHHCLGAPLARMQLRTAYQALWRRFPELRLAVPHEEIRFRMPSSRVYSVDA
LPVAW

CYP166A1 Amycolatopsis mediterranei rifamycin.

MTDAISFEVPWDRTDKFDPPAVFDSLREERPLAKMVYPDGHVGW
IVSSYELVREVLSDLRFSHSCEVGHFPVTHQGQVIPTHPLIPGMFIHMDPPEHTRYRK
LLTGEFTVRRASRLIPRAEAVAAEQIEVMRAKGAPADVVMDFAKPLVLRMLGELVGLP
YEERDRYVPAVTLLHDAEADPAEAAAAYEVAGKFFDEVIERRRQRPQDDLISSLVTED
LTQEELRNIVTLLLFAGYETTEGALATGVFALLHHTDQLAALRAEPEKLDAAIEELLR
YLTVNQYHTYRTALEDVKLEGELIKKGDTVTVSLPAANRDPAKFGCPAELDIERDTSG
HVAFGFGIHQCLGQNLARIELRAGFTALLRAFPELRLAVPADEVPLRLKGSVFSVKKL
PVSW

CYP166B1 Streptomyces peucetius

MTQSRESENRLARPFPTARPSGCPFDPPAPFAEAREECPVTPLRYPDGHLGRLVTGLQSA
RAVLGDVRFSSLPAGKRSPVKVPGSELSTDALPAGMFVNMDPPEHTRYRRLLSKHFTLRR
VRELRPRIQEMTDRLLDDTESSGGPVDLVAAFAKPLPMLVTSELLGLPEEDRAPFGHHVD
VLFSLSSSGEEMQQSMVLLAGMLHALINAARKDPGPDILGRLTVETELTDEELLGITTVL
LIAGLETTTHMLALGTYALLRHPEQLAALRADWSLMDDAVEELLRYLSVVQIGPIRVAAE
DFEFEGQSIRKGEVVTVSLPAANRDPQGFEDPDTFDIRRGAARHVAFGSGPHQCMGHHLA
RLELSIGYESLLRRFPRLELAVPAQEIGTREMMVTYGVPELPVRW*

CYP167A1 Sorangium cellulosum = Polyangium cellulosum

MTQEQANQSETKPAFDFKPFAPGYAEDPFPAIERLREATPIFYW
DEGRSWVLTRYHDVSAVFRDERFAVSREEWESSAEYSSAIPELSDMKKYGLFGLPPED
HARVRKLVNPSFTSRAIDLLRAEIQRTVDQLLDARSGQEEFDVVRDYAEGIPMRAISA
LLKVPAECDEKFRRFGSATARALGVGLVPQVDEETKTLVASVTEGLALLHDVLDERRR
NPLENDVLTMLLQAEADGSRLSTKELVALVGAIIAAGTDTTIYLIAFAVLNLLRSPEA
LELVKAEPGLMRNALDEVLRFDNILRIGTVRFARQDLEYCGASIKKGEMVFLLIPSAL
RDGTVFSRPDVFDVRRDTGASLAYGRGPHVCPGVSLARLEAEIAVGTIFRRFPEMKLK
ETPVFGYHPAFRNIESLNVILKPSKAG

CYP168A1 Pseudomonas aeruginosa

MDDAFSEEGSAQPRHDAQRPALAPRSDGFDIHTYHPDFVADPYP
LLRLIRSRAPVCRDQASIWWISRYADVSACLRDRRFSADPARLGAAGVRQGGASWFGH
QQLQPLARFYDNFMLFNDAPRHTRLRRLFAPAFGPDAVRRWEARIEVLVEELLDSLLE
RREPDLLRDFAEPLTIRVAAELFGFPREDTGQLLPWGRDLAAGLDLAASHGDAGQINR
SAVAFSDYLQRQARGWSDGSSRPPSGAAPSILDGAAMLEAGLGLEDLVAAYAMVFMAA
FETTISMVGNATLALLTHPDQLDLLRRCPELAANAVEELLRFDGAVRGGVRCTLEEVE
IGGQRIPPGEKVWLSFLAANRDPEMFAAPDRLQLQRANAKQHVAFAHGPHYCLGAYLA
RLELQCALRGLVRRRFALASEPTDLRWRRSSVFRTLERLPIVPEGDAQKTCE

CYP169A1 Pseudomonas aeruginosa

MQQTIDCPIRRRLAHLPWANDGRAGVRHWLEMQRDPLAWLQKMH
VAQPDLAVARMGPQRLWCLFHPQAVQELMVDRRDDLQRWQPALCMLKQWNGRSFMMRE
GAPAQARRKEVRPHLAPPPASEVRRLAAEWGERVEEGREYDLDLEMAAFSVTLSGHAL
FDVDLQPSAYRIAKAVRLLSRVALLEMSTGLPLGHWFPSKLCPRKRWALGQLREAVGE
VAERSPRPLADLRDELCTLLMASHQSTGVTLTWSLLLLAQRPELLARLRAELAGVNWT
AIRSVADLRDCALLRAVLQECLRLYPPAYGLAPRQVTADIEVFGQRLKRGDVTMVSSW
ITQRDPRWFEAPLEFRPERFLEPARWPRGAYFPFGLGDRACPGTAMAMIDLAAALAYW
VEHWDIMHDGDLAPRGWFSLRPQRARVRFRRRA

CYP170A1 Streptomyces coelicolor cosmid 7E4 gene=”SC7E4.20

MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDP
LAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKE
GVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFR
VAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFND
ALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGS
ETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRL
RPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERA
ANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLR
PHDLLVRPVAR

CYP170A2 Streptomyces avermitilis

MTLESVKPEAPEAPQLRNPPLAGGGIPGLGHGWKLARDPLGFLAQLRDHG
DIVRLKLGPKTMYAVTTPALTGELALSPDYEIGGPLWESLEGLLGKHGVA
TANGPTHRRQRRTIQPAFRLDIIPEYGPIMEEEARAFAARWQPGEIIDCT
SESFRVAVRIAARCLLRGHYMDERAERLSIALTTVFRGMYRRMVIPAGPL
YRLPLPANRKFDRALADLHLLVDEIVAERRASGQKPDDLLTALLEAKDDN
GDPITEQEIHDQVVAILTPGSETIASTIMWLLQVLTEHPEHAAKVCAEVE
SVTGDRTVAFDDVRKLSHTNNVVVEAMRLRPAVWILTRRAVTETELGGYR
IPAGADIVYSPYAIQRDPRSYAEHLEFDPDRWLPERSKDLPKYAMRPFSL
GNRKCPSDHFSMAQLTLITATVAAKWRFEQVSESSDATRVGITLRPHRLL
LKAIPR

CYP171A1 Streptomyces avermitilis polyketide synthase gene MMSQSTSSIPEAPGAWPVVGHVPPLMRQPLEFLRSAADHGDLLKLRLGPK

TAYLATHPDLVRTMLVSSGSGDFTRSKGAQGASRFIGPILVAVSGETHRR
QRRRMQPGFHRQRLESYVATMAAAAQETADSWSAGQVVDVEQAACDLSLA
MITKTLFFSDLGAKAEAALRKTGHDILKVARLSALAPTLYEVLPTAGKRS
VGRTSATIREAITAYRADGRDHGDLLSTMLRATDAEGASMTDQEVHDEVM
GIAVAGIGGPAAITAWIFHELGQNAEIESRLHAELDTVLGGRLPTHEDLP
RLPYTQNLVKEALRKYPGWVGSRRTVRPVRLGGHDLPADVEVMYSAYAIQ
RDPRWYPEPERLDPGRWETKGSSRGVPKGAWVPFALGTYKCIGDNFALLE
TAVTVAVVASHWRLHALPGDEVRPKTKATHVFPNRLRMIAEPRSVVRLEE
PAAMGA

CYP171A2 Streptomyces nanchangensis

MPAPLQVPDVPGSWPVVGHLPQLARRPLDFLSSLADHGDLVRIR
LGRKPVYVATHPDLVRSLLVTDAHAYTRGAGHAKALAFIGPILVATTGEPHRRQRRMM
QPCFHRQRLGSYVSAMCSAATETADSWSAQDVVDVVPVMTELATAMIAKSLFVSERAA
HAEAELRKTGNAILTVARMSAILPGIYRRLPTPGNRQLPPARTVIEETIAAYRAEGQD
HGDMLSTLLRTTDATGTGLTDEEIRDEVMGLAITGIGGPAAIASWIFYELGQNPDLER
RLHEELDTVLDGRPPSSQDLTRLVFTQRLVKEALRKYPGWVGARRTRESVRLGGHEIP
ADAEVMYSAYALQNDPRWYPDPERFDPDRWDPQQNATRVKKGAWVPFSGGVYKCIGDA
FTETETAVAVAVIASRWRLRPADGRSVRASHLATHVVPRPLRMVVEPRSRNKDEAERS
PHEAPQVSR

CYP171A2 ortholog SBI_9777 Streptomyces bingchengensis

99% to CYP171A2 Streptomyces nanchangensis
only 2 aa diffs, missing 15 aa at N-term
VVGHLPQLARRPLDFLSSLADHGDLVRIRLGRKPVYVATHPDLVRSLLVT
DAHAYTRGAGHAKALAFIGPILVATTGEPHRRQRRMMQPCFHRQRLGSYV
SAMCSAATETADSWSAQDVVDVVPVMTELATAMIAKSLFVSERAAHAEAE
LRKTGNAILTVARMSAILPGIYRRLPTPGNRQLPPARTVIEETIAAYRAE
GQDHGDMLSTLLRTTDATGTGLTDEEIRDEVMGLAITGIGGPAAIASWIF
YELGQNPDLERRLHEELDTVLDGRPPSSQDLTRLVFTQRLVKEALRKYPG
WVGARRTRESVRLGGHEIPVDAEVMYSAYALQNDPRWYPDPERFDPDRWD
PQQNATRVKKGAWVPFSGGVYKCIGDAFTETEPAVAVAVIASRWRLRPAD
GRSVRASHLATHVVPRPLRMVVEPRSRNKDEAERSPHEAPQVSR

CYP172A1 Campylobacter jejuni subsp. jejuni NCTC 11168

GenPept CAB73835
100% match
1 MSECPFFPKP YKNKASTLLT FLLKRRSWLD GLYERSYKMQ TGYVKMPNFD LYVINDTKEV
61 KRMMVDEVRE FPKSAFLHEL LSPLLGESIF TTNGEVWKKQ RELLRPSFEM TRINKVFNLM
121 SEAVADMMDR FSKYPNHAVI EVDEAMTFIT ADVIFRTIMS SKLDEEKGKK ILNAFVTFQE
181 QSVHTAMRRM FRFPKWLSYV LGDCKRAKAG DVIRQVLSDI IKPRYDMADN AEFEDILGSL
241 LLVVDADTNK RFSFEEILDQ VAMLFLAGHE TTASSLTWTL YLLSLYPKEQ EKAYEEITQV
301 LQGGVIEISH LRQFKYLTNI FKESLRLYPP VGFFAREAKK DTQVRDKLIK KGSGVVIAPW
361 LIHRHEEFWT NPHGFNPSRF EGEYKKDAYL PFGVGERICI GQGFAMQEAI LILANILKTY
421 KLELEEGFVP DVVGRLTVRS ANGMRIKFSK RKL

CYP173A1 Mesorhizobium loti

1 MDTQPAPFVP PAPKPRTSPP STLEMIRIVY RNPLELWGEP TYNEPWISAN GVGGHLIVAN
61 DPGLIRHVLV DNAKNYKMAT VRQKILRPIL RDGLLTAEGE VWKRSRKAMA PVFTPRHIFG
121 FAQPMLKRTK EFVTRYEEGG ASDIAHDMTL LTYDILAETL FSGEIAGEPG SFANEIDRLF
181 ETMGRVDPLD LLRAPDWLPR LTRIRGRKTM AYFRKIVTDT VKMREEKFRR DPDAVPQDFL
241 TLLLKAEGPD GLTRSEVEDN IITFIGAGHE TTARALGWTL YCLAESPWER NRVEQEIDEV
301 LAREPDPTKW LDAMPLTRAA FDEALRLYPP APSINREPIE PEMWKDLYIP RHAAVLVMPW
361 VVHRHRKLWD RPDAFLPERF HPGNREKIDR FQYLPFGAGP RVCIGASFAM QEAIIALAIL
421 LSRFRFDTTA ETKPWPVQKL TTQPQGGLPM QVTPR

CYP173A2 Sinorhizobium meliloti 1021

MDTRPEPFEPPAPVPRTGIPSRLEIIRTVLRNPLELWGEPSYTL
PWIETKFINQRTLIVNDPGLIRYILVENAANYEMSNVRRLILRPILRDGLLTAEGEVW
KRSRKAMAPVFTPRHAQGFAGQMLRVCEAFVDRYAGASSEPFVTNVAVDMTELTFEIL
AETLFSGEIAVEKQGFAANVEELLHRMGRVDPMDLLVAPSWVPRLTRIGGRKVLDRFR
GVVSETMSLRRRRTTEAPGDVPNDFLTLLLQLEGPDGLSTSEIEDNILTFIGAGHETT
ARALAWCFYCVANTPAYRETMEQEIDSVLASGADPVDWLGRMPHVLAAFEEALRLYPP
APSINRAAIEEDAWTSPEGERVPIRKGISVLVMPWTLHRHALYWQKPRAFMPERFLPE
NRDKINRFQYLPFGAGPRVCIGATFALQEAVIALAVLMHRFRFDLTDETHPWPVQRLT
TQPRGGLPMKVSARVK

CYP173B1 Magnetospirillum magnetotacticum

NGLLTAEGDEWRLQRRTLAPIFSARHVAGFVAQMDAAGARLGRRLARRDGATVDIALEMT 1287
1286 RATLDVLERTIVHAKGLPGPIPDALGRAITRLLESVGPIDP 1164
1185 SDVFGFPAFVPRLGRLRAGRHCVSSRRW*HLLDGRKQALARGEAPHDLM 1015
1014 TLLLAAQDPETGRGLSDIEVKANIVTFIAAGHETTANALTWALYCLSQDGAARARVEAEA 835
834 DAAAGPEGNLRLDRLPFTKAVMEETMRLFPPVPFLSRQALRDDRIGRVKIPRNSTVIV 661
660 APWVMQRHRKLWDEPDAFIPDRFFGSRRESIERYAYLPFGAGPRVCIGQSFSVQEATLVL 481
480 AHVARAVRFTLPDEHPPVTPLHRVTLRPKDGLRMVARRRM* 358

CYP174A1 Halobacterium sp. NRC-1

MGPMETYVVTEPALVERLLVSDAAEFRKPEFQADAIDDLLGDGL
LLSEGESWREQRGRANPAFSMARVAGFDADIAAHAADRVDDWPVGDTVDVEAAMTHIT
LDVILDVMLGVSLPEARVDAIGDALEPVGARFEPDPVRFAVPEWLPMPDDREYAAAVA
TLDDLVDDIVAAREGTASGGDGDDPMDLLSVLLRARDRGEQSLDRLRDEVMTTLLAGH
DTTALTLTYTWFLLSEHPDVEARLHAELDGALDDGAQPTVAQLQDLDYLEWVLQESMR
LYPPVYNVFRTPIEPVELAGSEVPAGAPIMLPQWAIHRSPDHWDDPEAFDPERWRPER
RADRPRFAYFPFGGGPRHCIGKQLALLEAKLIVATVASDYRLRYEGDTPLSFVPSLTI
HPEQEMRMRVEPR

CYP174A2 Haloarcula marismortui ATCC 43049 (Euryarchaeota; Halobacteria)

YP_134859, AAV45153 GenPept, NC_006396.1:56503..57840 genomic
62% to 174A1
1 MSKTPPGPKG EPLFGSSRTY ARDPFRFISA LERAYGDVAR FDMGPMDTVM LCDPTAIERV
61 LVSEADRFRK PDFQGDALGD LLGDGLLLSE GETWEQQRKL ANPAFSMARL SGMADRITGH
121 AEDRIADWSH GDVIDAEQSM TRVTLDVILD LMMGVELSEQ RVQTIEEQLL PLGQRFEPDP
181 IRFAMPQWMP MPDDAEFNRA VRTLDEVLDD IIEVREDSLG TDEDGPMDFL SVLLRARDDG
241 NQSPEQLRDE MMTMLLAGHD TTALTLTYTW FLLSEHPEVE QRVHEELDDV IGDDRPGMEH
301 VRELDYLEWV IQEAMRLYPP VYTIFREPTE DVTLSGYEVE AGTTLMVPQW GVHRSERFYD
361 DPETFDPERW KPERASERPR FAYFPFGGGP RHCIGKHLAM LEAQLITATT ASQYRLEFQG
421 ETPLELLPSL TAHPRQKMSM RVQER

CYP174A3 Halomicrobium mukohataei DSM 12286 (Archaea; Euryarchaeota)

ZP_03873471
72% to CYP174A2 Haloarcula marismortui
1 MAETPPGPKG EPLFGSSRTY AQDPFRFVEA LEDAYGGVAR FDMGPMDTLL IAEPELVQQI
61 LVDDDAKYRK PDFQDDALGD LLGDGLLLSE GDTWQEQRKL ANPAFSMARL ADMDDRIVDH
121 AESLVADWQD GSVVDAERGM THVTLDVILD LMMGVELPDE RVTTVQDQLV PLGARFEPDP
181 IRFAMPDWVP MPDDAEFDAA METLDGVLDD IFERRRGTTG DEDDGPMDFL SILMRARDRG
241 EQSDEQLRDE MMTMLLAGHD TTALTLTYTW FLLSEHPEVE QRLHEEIDAV VGDERPTIDH
301 VQELEFLDWV IDESMRMYPP VYTIFRTPTD PVELGGYDVA PSTNLMLPQW AVHHSERHWE
361 NPEEFDPERW SPERSEDRHR FAFFPFGGGP RHCIGKHLAL LEAKLIVATV AKDYRLRFEG
421 ETPLELVPSL TVHPRQEMSM RVEER

CYP174B1 Halorubrum lacusprofundi ATCC 49239 (Euryarchaeota; Halobacteria)

ZP_02017101.1, EDN48184.1 GenPept, NZ_ABEB01000009.1
complement(36125..37534) genomic
63% to YP_659381 Haloquadratum walsbyi, 53% to 174A1 with an insertion
1 MSATPPGPIG DPVFGNGRQY ADDPFSFMRA CADSYGDVVR FDLGPRETYM LTNPADVERV
61 LVADAERYRK PDFGDDAIDT LLGNGLLMSE GETWERQRRL ASPSFHSRRI GALAGTMVEH
121 TESQLADWAD GEVVDVQLEV ARLTVKIIVS AMFGADITDE EVKTVQEKLE PLGARFEPDP
181 RRFLIPNWMP TRENREFDAA IGTLESVIDG IVDRRRGTEY DPSVDPAGPG GVAVRGPVGD
241 GPDGDGAGDL PMDLLSVLLR ARDRGEQTDE NLRDELVTML LAGHDTTALA LTYTFYLLSN
301 HPEARERVAR EAAAATADGP PTAADAREMK FTERVLNESL RLYPPVYTLF REPKLDVKLG
361 GYRIPEGSAL MLSQWAIHRS PRWYDDPETF DPSRWEPERQ SKRPRFAFFP FGGGPRHCIG
421 KAFSLLEAKL ILAEVCSRYD LDYEGPDLSL RGSLTMHPDH PVPMRIRER

CYP174B2 Haloquadratum walsbyi DSM 16790 (Euryarchaeota; Halobacteria)

YP_659381 GenPept, NC_008212.1:3112950..3114311 genomic
CAJ53807 GenPept, AM180088.1:3112950..3114311
1 MSTQPPGPNG VPVFGNSRQY ASDPFTFLRS VADAYGDVVR FSLGPLDTYM LTNPVDIERV
61 LVTDDQKYQK PDFQDDAIGT LLGDGLLLSE GETWQKQRQL AQPAFGPKRI TSLAGTMTDH
121 TRGMLDGWEP GDIKDVHLEM ARVTVRIIVE AMFGTSLTDT QTTAVQENLE PLGKRFEPDP
181 LRFIIPDWVP TQENQEYHKS VSVLEDIIDE IVSERRGTET NSDIDPGAGS DDDPMDLLSI
241 LLRAKQRGEQ TDKQLRDEMM TILLAGHDTT ALTLTYTWYL LSEHPKVRDQ VHEELASVCG
301 GETPTMADTR SLDYTERVLQ ESMRMYPPVY VIFREPQVDV RLGGYRIPAG SAIMLPQWVV
361 HRSPRWYDNP TTFDPDRWRP ERRADRPRFS YFPFGGGPRH CIGKHLSMLE AKLILGTVAQ
421 SYELDYVRDR PFDLRGSLTM HPDEPMGMRV TER

CYP174B3 Halobaculum gomorrense Euryarchaeota; Halobacteria

BZ894476.1, BZ894445.1
54% TO 174A1, 60% TO 174B2, 66% TO 174B1
GRAGDLGRRRPHRRATGARAAHRPDHRHRDVGTDIDEETVRAVQENLEPLGQRFEPNPMR
AVIPNWAPTRENRRFDDAVATLEGVIDDLVARRRGTEETAPDPAGDAVDSPMPMDLLSIL
LRAHDRGDQTEGDLRDELMTMLLAGHDTTALALTYTFYLLSKHPEAKARFQREVDALDGT
PTAADLRDLSFTDRVLSEAXXXXXX
VYTLFRESKVDARVAGYRIPEGSLIMLPQWVVHRSDRWYDDPLAFDPDRWAPGRRADRPR
FAYFPFGAGPRHCIGKQFSLLEAKLILATVGRAFDLEYEGPELDLRGSLTMHPDHPMPLR
LSSR*

CYP174B4 Halogeometricum borinquense DSM 11551 (Archaea; Euryarchaeota)

ZP_03998664, EEJ57769, ABTX01000001.1 1368411-1369736
76% to CYP174B2 Haloquadratum walsbyi DSM 16790 (Euryarchaeota; Halobacteria)
1 MPLFGNSREY AKDPFTFLRQ VSEAYGDVVY FGLGPLDTYM LTNPADIERV LVSEDAKFHK
61 PDFQDDAIGT LLGDGLLLSE GETWRKQREL AQPSFDPRRI AALGETMTDH ATAMVEGWND
121 GEVRDVQLEM ARVTVKIIVD AMFGSSLADE RVRTVQENLE PLGKRFEPDP LRFLIPDWAP
181 TRENREYKQS ISILEGIIDD VVAERLGTEN DPSAAVAGED GAPMDLLSVL LRAKQRGEQT
241 DQQIRDEMMT MLLAGHDTTA LTLTYAFYLL SQHPESEAKV QAEVDKVCGG ETPTVADVRQ
301 FDYLERVLQE AMRLYPPVYV IFREPQVDVR LGGYRIPSGS AIMLPQWVVH RSPRWYDAPT
361 EFDPDRWRPE RRASRPRFSY FPFGGGPRHC IGKQFSMMEA KLILATVAQA YELDYVRDRP
421 FSLRGSLTMH PEEPMGMRLR AR

CYP174C1 Halomicrobium mukohataei DSM 12286 (Archaea; Euryarchaeota)

ZP_03874667
42% to CYP174A2, 41% to CYP197C1, 41% to CYP1002A1 (borderline member)
1 MTTTDAPGPR GLPVIGNSHQ WARDPCAFRE RCAAEYGPVV NYEMLGWDTY MLTDPADVKR
61 VLEDPDTFPK HEPSNAQLEA FVGNGLLTSG GDLWERQREA IQPAFYMDHI RNYAERMVAQ
121 AAATADRWTA GESVDVRRAM TRCTLDILVD CLFGQEIDPA ERGLYEAVEA FQAPLEPSKQ
181 PITFFAPDWA PVPFLRRADR ALSHIDDQIY DIVETRRADE ADRDDLVAML IAADTAMDDE
241 QIRDELVTFL FAGHETTALS MTYVWDLLSR NPTAQRRLHE ELDALLDGRP TIEDVFDFEY
301 TGAVIEEAMR LYPPAHDIRR SPATTVEIGG YTIPEGSLVT LPTWVLHRDE RFWDDPEQFR
361 PGRFLDGGRS DRPEYAYFPF GGGPRRCIGQ QFAMTEAQLI LATIASEWTL EREYGDLELS
421 AAVTLQPSHD VAMTPHRRD

CYP175A1 Thermus thermophilus

MKRLSLREAWPYLKDLQQDPLAVLLAWGRAHPRLFLPLPRFPLA
LIFDPEGVEGALLAEGTTKATFQYRALSRLTGRGLLTDWGESWKEARKALKDPFLPKN
VRGYREAMEEEARAFFGEWRGEERDLDHEMLALSLRLLGRALFGKPLSPSLAEHALKA
LDRIMAQTRSPLALLDLAAEARFRKDRGALYREAEALIVHPPLSHLPRERALSEAVTL
LVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQEALRLYPPAWILTRRLE
RPLLLGEDRLPPGTTLVLSPYVTQRLHFPDGEAFRPERFLEERGTPSGRYFPFGLGQR
LCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVLAQVTLRPEGGLPARPREEVRA

CYP175A1 Thermus sp. NMX2.A1

MKRLSLREAWPYLKDLQQDPLAVLLEWGRAHPRLFLPLPRFPLA
LIFDPEGVEGALLAEGTTKATFQYRALSRLTGRGLLTDWGKSWKEARKALKDPFLPKS
VRGYREAMEEEARAFFGEWRGEERDLDHEMLALSLRLLGRALFGEPLSPSLAEHALKA
LDRIMAQTRSPLALLDLAAEARFRKDRGALYREAEALIVHPPLSHLPRERALSEAVTL
LVAGHETVASALTWSFLLLSHRPDWQKRVAESEEAALAAFQEALRLYPPAWILTRRLG
RPLLLGEDRLPPGTTLVLSPYVTQRLHFPDGEAFRPERFLEERGTPSGRYFPFGLGQR
LCLGRDFALLEGPIVLRAFFRRFRLDPLPFPRVLAQVTLRPEGGLPARPREGVRA

CYP176A1 Citrabacter braakii

MTATVASTSLFTTADHYHTPLGPDGTPHAFFEALRDEAETTPIG
WSEAYGGHWVVAGYKEIQAVIQNTKAFSNKGVTFPRYETGEFELMMAGQDDPVHKKYR
QLVAKPFSPEATDLFTEQLRQSTNDLIDARIELGEGDAATWLANEIPARLTAILLGLP
PEDGDTYRRWVWAITHVENPEEGAEIFAELVAHARTLIAERRTNPGNDIMSRVIMSKI
DGESLSEDDLIGFFTILLLGGIDNTARFLSSVFWRLAWDIELRRRLIAHPELIPNAVD
ELLRFYGPAMVGRLVTQEVTVGDITMKPGQTAMLWFPIASRDRSAFDSPDNIVIERTP
NRHLSLGHGIHRCLGAHLIRVEARVAITEFLKRIPEFSLDPNKECEWLMGQVAGMLHV
PIIFPKGKRLSE

CYP177A1 Rhodococcus rhodochrous strain 11Y

MTDVTVLFGTETGNAEMVADDIASALGEFDIEATVVGMEDFDVADLAASGTVVLVTSTYGEGELPATTQPFFDAMKAAEPDLTGLRFGAFGLGDSTYDTYNNAIDILVGAVTDAGATQVGATGRHDAASFQPADGPVAEWAKQFAEALSDRTRRGGHEMTAASIDRELVPWSDPE
FRNNPYPWYRRLQQDHPVHKLEDGTYLVSRYADVSHFAKLPIMSVEPGWADAGPWAVASDTALGSDPPHHTVLRRQTNKWFTPKLVDGWVRTTRELVGDLLDGVEAGQVIEARRDLAVVPTHVTMARVLQLPEDDADAVMEAMFEAMLMQSAEPADGDVDRAAVAFGYLSA
RVAEMLEDKRVNPGDGLADSLLDAARAGEITESEAIATILVFYAVGHMAIGYLIASGIELFARRPEVFTAFRNDESARAAIINEMVRMDPPQLSFLRFPTEDVEIGGVLIEAGSPIRFMIGAANRDPEVFDDPDVFDHTRPPAASRNLSFGLGPHSCAGQIISRAEATTVFAVLAERYERIEL
AEEPTVAHNDFARRYRKLPIVLS

CYP178A1 Streptomyces avermitilis

MIDLADLDLFTDGDPHEAWRVLRRDRPVHWNATGGDTASGVGPSGFWALT
RYQDVHDAYVDAGLFSSRWGTVMGGSHRRDADSASGRMLIASDDPQHRLM
RQQVHRAFLPALMDRARRVVRDYVNAALDRVLKDGGGDFATDVAPELPAG
LLAAMFGLERRDALHLLALTRSMIGFQDPRYHSDSTPPAVLVSSQVEIFD
VMMDLMETRRRAPSDDLVSILLGASINGRRFTEDEVLYNCLNVAVGGNET
TPFTASAAVQAFMDFPDQAQRLLDDGGLLPTAVEEIFRWTSTNAYVQRVA
TRDVELHGQLIRAGDPVTLWNASANRDEEKFPNPDRFDVRRTPNRHIAFG
VGVHRCIGMGAAQMEIALLLKEIVRRGITFEPAGPPARLRSNFMLGLTCL
PVHATVAQDAS

CYP179A1 Streptomyces avermitilis

MDLELHGRLDELQRDPYPHYARARRFTALEHVPELDAWLVARDADVREVL
RRPDDFSSANALRPDVMPAPAALAVLGGGFGGRPVVVTADGARHQELRAP
IVRGLSPARVAAVLPYAAERATALVDRFLSGAESGRVELMAAYARRLPGD
VIGRIVGLDPADVPAVVYGGHRAEELLFRPLTEDEQVVAAQDVVAMQHLL
DAFVRDRRADPREDLASEIIASVAPGDGELTLDQRHDIVAHLQNLLLAGH
LTTTALIGTTVLNLLRHPRQWELLCAEPERIPAAIEEAARYDSALQGFRR
VTTRPVTLAGTELPAGASVFVAFGGANRDGGRHPRPDEFDITRTPRRHLA
FGFGVHGCPGAQLAREQLRLTLEQLTRRLPGLRPADDRPVTMRPTLIHRS
PRSLHLVW

CYP179A2 Streptomyces scabies SCAB19191

MDAELHGRLD ELQRDPYPHY ARARAAEGLT YVPELDSWLV ARDADVREVL RRPEDFSSAN
ALRPDVMPAP AALAVLGGGF GGRPVVVTAD GTLHQELRAP LVRGLSPARV AAVLPYAEER
AAALIDGFVE GGRVELMSAY AGRLPGEVVG RLVGFEPEDV PALVRAGHRA ERLLFRPMTE
AEQIAAAEDV VAAAHRLDAF VRARHADPRE DLGTELIRSV VGHGTDAANA TATSSATDAS
ELTLDHRHQV VSHPQNLLIA GHLTTTALIG TTLLHLLRDR RQWELLCAEP ERIPAAVEEA
ARHDTALQGF RRVTTRPVTL SGTELPAGTP VFLAFGSANR DGSRHPRPDD FDITRPAAGR
HLSFGLGAHA CPGSQLAREQ LRITLRLLTS RLPGLRLAED QRITMRTTLI HRAPERLDLVW

CYP180A1 Streptomyces avermitilis

MSVREQAPPVPDVFDPRRYAAGVPHAAYRTLRDHHPVARQAEPEVLGWPA
GPGFWAVTRHADVVRVLKDSTTYSSRFGATQIRDPDPDDLPFIRDMMLNQ
DPPDHGRLRRLVSRAFTPRRVDRFESLARDRARTLLAAALAGARAGDGSC
DLVATVTDDYALLNLADLLGVPESDRGLLLHWTRRVIGYQDPDEAGEPLL
DAAGKPVDPRSPGALRDMFEYARQLASYKREHPADDIMTTLATDPELTGP
ELAMFFFLLTVAGNDTVRGAAPGGLLALAEHPEAYARLRARPQQLPSAVE
ELLRWHPPVLTFRRTAVRDTDLAGQRIRAGDKVVVFHASANRDGRVFTAP
DRLDLSRSPNPHVSFGDGPHVCLGAHFARLQLRVLYAQTLRALPAPRVAG
PPGRLVSNFINGIKSLPLQVA

CYP180A2 Saccharopolyspora erythraea NRRL23338

VTATGVPDVFDPRRYSSGIPHADFAWLRANAPVSWQPEHAVGDWPAGPGFWAVTGYDDVV
RVLRSPGEFSSWLGATQIRDPAPADLPFIRRMMLNLDPPEHGKLRRIVSRAFTPRRVERF
RAEVAARARRLVDAVAERGGCDVPPDLTDDFPLLNLADLMGVPEADRRMLLEWTNRIIGY
QDPEHSEVVRDADGRPLNPRSPAMLADMFGYAQELAAHKRRHPADDLMTALATAEVDGGR
LSGAELEMFFFLLSVAGNDTVRSALPGGLRAFAEHPGQHRLLLESPELLDRAIEETLRYH
PPVLSFRRTATTDVELAGQAIPVGAKVVVFHCSANFDPARFDDPLRFDIRRDPNEQLSFG
TGPHVCLGAHFARLQLRAFYSEALWRLRDLHVTGPVRHLVSNFINGIKHLPVAFTAVRPR

CYP180A3 SBI_2082 Streptomyces bingchengensis

51% to CYP180A2 Saccharopolyspora erythraea NRRL23338
54% without insertion
missing about 5 amino acids at N-term
VNPDVVFLPETYAAGVPYALFAEARATRPVCWIEESAVGAWPAGPGFWAV
FRHADVKHVLRTPEVFSSHLGATQIRDPDTPGDLEFVRAMMLNQDPPDHS
RTRRVVAAAFTPRAVRELQAVIEARARTLVEGVAPRGEADFVELAADLPV
WTLAHVMGVPESDRGLLFDWASRVIGYQDAEYAASSTADAAGLSPMGRAA
LAHRPRSLTRPDGRPMNPRSREALADMFAYAHALAERPRPGTVMAHLREG
GLSREEFENMFFLFAVAGNETLRNGIPGGLLTLLDHPESHELLLARPELT
DSAVEEMLRFWPPVIDFRRTATREVELGGQRIRRGDKVVVYHASANRDEA
VFNDPDRFDITRSLGDHVSFGHGPHFCLGAHLARLQMRAMLRGALTRLPG
LRRAGEPVRLMSNFQNGLKHLPVSWETDR

CYP180B1 Streptomyces scabies SCAB9651

MKPRRTTDMT TSAHLPPALV REAVQEPLPL DDVNLADLDN FTDGVTPWRM FHTLRHEDPV
HWQPEEAPNS GFWAVTRHAD IARVDRDAET FTSTRFVNLE EVDENQIAIR ASILELDGVR
HRALRSVIQR QFGANVINSY TDFLRGLTAR TLDAALAKGT FDFVADVSAD FPINVLARLL
DVPPEDNQRL IDWGNRIIGN TDPDYADVLL HSAESERYRD LPFRSPASLE VFEYGRELAR
QRRGGEGTDL VSKLVNTTPR DGIPLSAQDF DNYFLLLVVA GNETTRHTIT HSMLALLQHP
EQLARLQEDP SLIPAATEEF LRWASPVYHF RRTATRDVEL GGKQVKEGDK VVMWYASGNR
DEAVFGNPYD FDVARADNDH VTFGKGSPHL CLGNLLARTE IRIMFEELIP RLADIRLVGD
VPRVRSNFVN GIKKLPVEVT LA

CYP181A1 Streptomyces avermitilis

MLPAEYETLRERGIGQVELPTGKLVWMVVRPEYARIVLSDPRFSSDKTDD
RFPKLTPNSLMKLRYCAPFMINLDGPEHLKKKKSIMDEFSPEGLARLLPR
LRVAVEEKIDDMLRQPTKPVDLVKELAFPIAWQLQEMFLGIPAAELETMR
DNVWKLLLGTTTEAEEREAADRLNGHAEEVLKEKAKHLGDDMMSRLIVQE
REKHGEVNWYELAPLMLSNAQGIHNSVSTMISLGVLTLLNHPEQRPTLLA
HPDRMTTAVDEMLRYFSVNDGTPMRLATEDMLIGDTLVKAGDGVAVPTLP
VNRDPSVCPYPHQLDIMREEPARHLAFGHGPHKCPADRLVPSLLEIVYTT
LFERVPTLALAVPEAELTYKYHSIQAFGPAEMPVTW

CYP182A1 Streptomyces avermitilis

MHGRCGMRSGMEAQPYATAPAGSPRLESLRVEPLLTSEFDADPAGVYERL
RRTYGPVAPVGLMGVPVWLVLDYHEVLEVLRDDSQWRRDIRYWRARAQGQ
LPRDWPLLAGYEVRQTMFLDGDEHHAARLTHHSALRPFQDGHSPQGWELR
AAVARYADELIALLAAESGSAGYADLGAQYTRPLLLMVTGKLFGCPVGLG
DELVMDLWRMLDGGPDAGPATDRAAAVMTRLAAHRRQRPGDDLTSYLLLA
DPGMTDEQLGRELLMNAVYLNDITGNMVMNTLLEVLRGNATVRRSVSDGH
LGETFHRVALVNPPVANMCFRFAAGDVRLGAFWIRAGDVVSPSAAAAHQD
LLTIGTSPLGDATASTRAHLGWGAGQHQCPGAARELAGMIVTTAVGRIFD
HFTKAELTLPADQLPWRSGPVVRGLRLLPVRYELRGTPSESHPVPPPRHD
GEAPDTAPTADHRSRGLLSALRRLMTGTGRAG

CYP182B1 Streptomyces scabies SCAB81761

MVREIRSDEG VSVDLDGARL EELSPQPLLT RDYETRPSLV YERLRQRHGA VAPVDLLGVP
AWLVLGYRES LQVLQDDAGW PKGLENWRAR TEGRVPADWP LAPSLEVNHV LIQGGPGYKS
LRTAWDQALK PFQDPRNPQT KRLKAAVTAY ADELITLMGE AGGTGLADLS AQFSRPLPLM
VASHLLGFPG SQGDDALMDM WRVLDAGPDA GPALDRLLGA LAELAELKLK TPGEDFPSYL
LAAHPDLSLD QLARELFMLL GMTSDHVGIL ISNTVVEVLS GEDSVRASLS AGMVREAMNR
VVMRKPPLVN FVPRFAAADS RLGEYTIRAG DPVWVSSAAA HADPLFADHV APTTTVSTRA
HLSWGAGPRQ CPARELASTV AAVGVGRLFE RFAHLDLALP VDQLPWRSSP FMRGLRSLPV
RYELAPTDQQ PPALDPAESG AGAGAGAGTP ARDVSARQRS SLWRYLTGLI RSGR

CYP183A1 Streptomyces avermitilis

MSQHTFVAGTAPGAVPVVGHAWQMMRRPLHFMSSLSAHGDLVKIRIGPTS
AYVPCHPELLRQVLTNDRVFDKGGVFYDRARDIAGNGLVTCPYRDHRRQR
RLMQSAFQRTQLERYSTAMRAEIDATAARWHDGTVIDAFPELYGMALRTV
ARTLYSTPVTEELAQRVEQAFDTVLNGLFRQMFLPHSLRRLPTPANLRYR
NNLRFLHDTVQDLITEYRRDDTQRDDLLSALLASRDEDGGRLGDTEIHDQ
VITVMAAGTETVAGTLTWIFHLLSRHPEIEARLYEEIDTVLDGKPPHWDD
LPSLSLTDRIITEALRMYPPAWIFTRLTASDVDLAGVRLPEGTTIVFSPS
SVQRHSEAYDDASRFDPDRWLPDRTSAVARQAFTAFGTGARKCIGDLFAR
TEATLALATMLSQWRVTVEPDADVRPVALATVYHPRRLRLRLTARTPGQ

CYP183A2 SBI_10598 Streptomyces bingchengensis

72% to CYP183A1 Streptomyces avermitilis
VNFMASLSAHGDLVEIKIGPTTAYVPTHPELLRHVLTNDRIFDKGGIFYD
RARDIAGNGLVTCPFADHRRQRRLMQSAFTRGQLKRYAEAMHAEIEDTAS
RWQDGMVVDAFQEMYGLALRTVGRTLYSTPVSPELAAKVERSFDVVLNGL
FRQMFLPASIRRLPLPSQRRYKSNLDFLHETTQQLIDDYRSSDTERDDLL
AALIASRDDDGGKLGDKEIHDQVITVMAAGTETVAATLTWVFYLLSQHPE
IEAALYDEIDTVLDSRAPQWDDLPNLSLADRIISETLRLHPPAWLFTRLT
ASPTELAGRQLPTGSTVVFSPAAVAQYEDAFDNPKKFDPDRWLPDRIAPA
SRHAYVPFGTGARKCIGDLYARTEATLGLATILGRWRVTCEPGMDIRPVP
LATVYHPRRLRLRLDARTPRRKTSAVPVPAGGDVT

CYP183B1 Mycobacterium marinum MM0281

MPTSIPIAPA ALPLLGHTLP LLRNPLSFLL SLPARGDLVR IRIGPATAVV ACTAELTHEI
LCDDRIFDKG GIFFDRFREM LGDGLGTCPR SQHRRQRRLL QPAFHTQRLP GYAQTMTTEV
AATVGRWQNG QIIDVPAEMM AITGRTLLAT MFSNSLPNPA LRQALDDLTA IFAVLYWRML
TPPPLDRLPT VGNRRYHRAS ARLRHTIGSA VAGRRAAGVD RGDLLSAILA SHEVDSSTVA
FTDTEVIDQI VSFFIAGTET TALTVAWALY LLAEHPAIEQ RVHAEIDPVL AGRAATHADL
PRLGLVNRIV TETLRLYPPG WIISRVATAD VYLGGHRIPA GATVIFSPYL IHHRPDLYAE
PERFDPDRWL PERARAIGRN TYIPFGGGAR KCIGDNFGTT EAALALATIA ANWRMQRLPG
LPVRPAVAAS LRPRNLALRV TARTADRVPG EPGRRLTSRE IG*

CYP183C1 SBI_7103 Streptomyces bingchengensis

43% to CYP183B1 Mycobacterium marinum MM0281
MGPWPVHVVCHPELVHRLLASDRCFDKGGPLYDRLRGLIGDGLASCPHAV
HRRRRRLVQPAFHHTRLPLYAKVMTQQIDETTRSWADGQILDLREELTGL
ATRVLSRTIFTADFSGPAIAALIPYAELITAKLSWRLLWDAALKGVPTPG
KRHFARRTEELRSAVYTMARRYRASDTDHGDLMSMLLSARDDDGSGLTDA
EIFAEVVTMVLAGTGTVPNTLSWAFHTLAQHPDIAKRLHSEVDKVLGGRS
ATWDDLPALPLTAAIFTEAMRHFPSDWLVTRVTTEDTELAGRRLAAGSVV
AYSGQVIHRRPDLYPQPDLFLPDRWLDTDRKPPRGAFLSFGGGARKCIGD
KFGTIEGVLALSTIAARWRLEPAHPGRARSTSSSRRSTRPPAMRLVARG

CYP183D1 SBI_7104 Streptomyces bingchengensis

44% to CYP183A1 Streptomyces avermitilis
MTMPNTFTTGLAPGALPLLGHARQLRRQPLPFLESLPGVGDLAEIRLGRE
RVYVPCHPELVRQVLTDDHTFDRGGALQDHFVELFGECVATATYRGHRRQ
RRLIQPAFCHDRLEGYAPVVEAEVAALPDSWREGQTFDLFPVLYTLTLRS
VIRMLFSDRVDEATMDEVRRLFLAMTGGAAPRQGVARLIRGTGPTEGRRR
RAAHQLRGVVDRIVADYRRAGETGKDMLSALLTAREENGGRLDDTEVRNQ
AIIMLAAGSHSPATVLTSVFYLLAEHGGAEHRLHREVDAVLGGRPARWTD
LPDLAFTGRVITETLRLYAPAWTIFRKTTKEVRLAGRDLPAGTTVLVVPL
IPHRRGDLFDCPREFTPDRWRPECDTVTQRGAFKAFGGGARKCVGDVLGM
AELKLVVATIASRWRLECLPDARVRPHAGAVAPPPRYLPVRLVERRP

CYP183E1 SBI_7185 Streptomyces bingchengensis

43% to CYP183B1 Mycobacterium marinum MM0281
MDSGSAVVQAPGAIPVVGHLTAFLRAPLPFLRGLPAHGPLVTIRLGRQRV
IVVCDPELTRTVLVQDRVFDKGGPLYERLREAGGQGLASCPSGEHRRQRR
LIQPAFHHSRFPGYAHVMAERMDTLLGGWHDGQTLDLTTETRRIAADVVI
SAIFGTGLDAAVHTRLATDFHTLLAGFTRHTLTPKPLRKVPTPGNLRYER
ATRRVRRTMADLTTTYRAHGDTGETNLLSLLISARDPESDSPALTDDELV
DQAVTMYSAGTETTASAVCWALFLAALHPEVHDRLITEIDTVLDGRTADW
SDLPRLIYTRQVFTEAIRMYPPGWFLTRRTESDTRLGSYDLPKGTTIAYS
PYLISHLPGLYPDPETFDPDRWKPAERGPEVPVTVFGGGARKCIGDQFAL
VEGVLLLASLVSHWHIDFHPDSLSLPRLPQLTLNPGKMKATVTARRGGED
RQRHTSQSRVP

CYP184A1 Streptomyces avermitilis

MAAVTAAGAAQAPIVAGHPLLGSMNDLLNDPLATYLRARRDHGDVVRFRA
GPPGLRADIYAVFSAEGAQQVLATESGNFRKDNVFYGELRDSVGNGLLTS
QDATYLRQRRLVQPLFTRRRVDGYAGQVADEAAGLAEAWRGIPGGGVELV
GEMHRFALRVVGRILFGTDMETTFEVIERTLPLLQEYALKRGLAPVRTPR
TWPTPANRRAARTQAELFALCDGIIDSRRNRKNEGDGGEESGEDLVTLLV
RAGNAEDGSLDAAELREQVLIFLLAGHETTATALAFALHLLARHPEQQRR
VRDEADRVLGGPGGRAPTAADMEALPYLTMVLKEAMRLYPSAPVIGRRAV
ADAEVDGVRIPAGADLFVSPWVTHRHPDYWPDPERFDPERFTPEAEAGRP
RYAWFPFGGGPRACIGQHLSMLESVLGLAVLIREFEFEAVGEEEVPLGAG
ITLLAKGPARCRVIPRSSGPRSS

CYP184A2 SBI_734 Streptomyces bingchengensis

65% to CYP184A1 Streptomyces avermitilis
MATKASTTTAVDVSDVSDVTEVTEVTXXXXXKXXXXXPYAAGTPLLGSMS
DLLGDPLAAYLRARRDHGDVVRFRAGPPGLRREIYGVFSAEGIQQVLATE
AANFRKDNAIYEELRQALGNGLLTSQDEDYRRQRRLIQPLFTRRRVESYA
TAVTSEAAALAARWRETPGGADGALELVEEMRGYALRVVGRVLFGSDVEQ
TIEVVRDSLPMLNERARARALSPVKLPRDWPTPANRRAARAQAGLYALCD
AIISKRMDGREREEREEREQAPGPGHAPGPVPEDGAGPEDGAAEDLLTLL
IRAHNAEDGSLTRAELREQVLVFFLAGHDTTATALTFALHLLARHPAEQR
RVHEELDRALPDGRTPTAADLEALPRLTMVLKEAMRLFPPSPAVSRLAVA
ETVIGGRRIPAGAAVLVSQWVAHRHPAYWEDPERFDPERFTPQAEAGRPR
YAYFPFGGGPRACIGQHFSTLHSVLSLATLLRAYEVEDATDGGDIPLGAG
ITLLAKGPVRVRVRSRT

CYP185A1 Mycobacterium smegmatis

MRADTRFMVETASPPLTELPLAPRNTLPCREQIRCLRSFIDGMQRLRDVGGPVTRIV
LGPRWLVPPALLVTSPQGAHDVLSLPDAVADRGGSRNMRQLQRLMGGNLL
DLPHDRWLPRRRTLQPLFTKKHVPRFAGHMAAAAQSVAVSWADGATVDLD
RACRALTLRALGRSVFGVDLDQRAEDVGPALRTSLSWVADRASRPVNLPQ
WVPTRGQRKARAGNATLHRLAAEILADVRADPDRDAPLVRALLEARDPET
GRGLTDDQICDELVLFMLAGHDTTSTTLCYSLWALGHHPDIQERVYAEVA
ALGDRELTTDDVPQLTYTMRVLHEALRLCPPGSGTMRMLNEEMTVDGYRV
EAGTVAIVNFYAMHRSPTLWDAPERFDPDRFSPERSAGRNRWQYLPFGGG
PRSCIGDHFAMLEATLALATVIRAVSVESQNTDLPVETPFTVIAAAPVPA
RVTRR

CYP185A2 Mycobacterium smegmatis

MVSDVPAVTAPPGRSADASGANAKPDTGALPLAPRNPLSLRQMARAVRAL
DMGQQVIRAAGGAVTRVQFGPRWLVPPLVAVFSPEGIRDVLGRNDAFAER
CIVHDEVRHAAGDSLFVLPNEQWRPRKRALQPVFTKHSVRAFGGHMSRAA
QTLVDEWADQWAQADSLEVDLDAVCRRVTMQSLGRSVLGIDLNERADVIV
EHMHVASSYATDRALRPLRAPRWLPTPARRRARAAVAAMRAVTAEILQAC
RDDADRDAPLVRALMAAEDPETGERLSDEDICNDLLIFMLAGHDTTATAL
TYALWALGHHPEIQDRVAAEARALGDRELTPADVPQLGYTVQVLHESLRM
CPPAAGVGRLALRDIAVAGHRVEAGSLVALGIYAVHHDPQLWPDPEVFDP
DRFSPENSRERDRWHFIPFAGGARACIGEHFARLETTLALATIIRSVVVG
SVDAEFPVDVPFTTVAKGPIRANVAPRGPDHYTL

CYP185A3 Mycobacterium avium subsp. Paratuberculosis old CYP277A1X

MSVAEPKRDIAGLPLAPKNPLSYRERLRAIKEFHTGTNKLRDAG
GPVTRVTLGPRWLISPIVLATSPQGIRDIVSVRDGSIDKTSTVATELRRLLGPNLFVL
PHTEWLPRRRTLQPVFTRQRVREFGGHMAEAAESVCAGWPEDTEIDLDAQCRTLTLRA
LGRSVLGLDLDERSDAIAEPLRVATSYAVRRALRPLRAPEWLPTPSRRRARAAAGAIR
ALADEILQACRADPGREAPLVHALIAATDPETGQALSDKEIRDEMIIFLFAGHDTTAT
TLTYALWALGRHPEYQARVAAEVAELPDRHLTPDDVARLGFTVRVLQEALRLCPPGPT
GTRMATRDVEVAGYRVEAGTMLAFGRMAVQTDPSLWDAPLRFDPDRFDPRRAGDRDRW
QYLPFGGGPRSCIGDHFAMLEATLALATIVRRVEIESLSDDFPLAVPFTMVAAAPIRA
MVRRRR

CYP185A4 Mycobacterium marinum MM0852 old CYP277A2X

MVDSPDVRSL PLAPRNPLPY WQQLKALKTL HVGSEALRDA GGSVTRIWLG PKRLVPPMVM
VTSPQGARDV LGRSGALSDR GTLPLLKDLR RAIGESVLNL PHDTWLPRRR TLQPIFTKQR
VAGFAGHMSE AANHILLGWP DGAEVDLNAA SHALVLRVVG HSVFGLDLQD KADVITTGVT
LAAKWAADRS ARPVRAPHWL PTPARRRARG AYDAMYKIAA DMLAACRADP NREAPLIRAL
IDATDPNTGE SLSDQQICDE MVYFMILGED TTSTVLTYAL WALGRHSQLQ DRVAAEAAEL
GDRPLTPADV PRLGYTIQVL QEAMRLCPPG PTVARRAMQD IEVDGYRVQA GTYCLVGVYA
MHRDPALWDD PLAFDPDRFA PKKSKGRDRW QYLPFGGGGR SCLGDHFAML EASLALATII
REAEIHSLDG DFPVAIPLPI VPAGPIRARV NQRRPSQEVC TTTLSDSSAS SSAS*

CYP185A4 Mycobacterium ulcerans old CYP277A2X

VVDPPDIRSLPLAPRNPLPYWQQLKALKTLHVGSEALRDAGGSVTRIWLGPKRLVPPMVM
VTSPQGARDVLGRSGALSDRGTLPLLKDLRRAIGESVLNLPHDTWLPRRRTLQPIFTKQR
VAGFAGHMSEAANHILLGWPDGAEVDLNAASHALVLRVVGHSVFGLDLQDKADVITTGVT
LAAKWAADRSARPVRAPHWLPTPARPRARGAYDAMYKIAADMLAACRADPSREAPLITAL
IDATGPNTGESLSDQQICDEMVYFMILGEDTTSTVLTYALWALGQHCQLQDRLAAEAAEL
GDRPLTPADVPRLGYTIQVLQEAMRLRPPGPTVARRAMQDIEVDGYRVQAGTYCLVGVYA
MHRDPALWDDPLAFDPDRFAPKKSKGRDRWQYLPFGGGGRSCLGDHFAMLEASLALATII
REAEIHSLDGDFPVAIPLPIVPAGPIRARVNQRRPSQEVCTTTLSDSSASS

CYP185A5 Mycobacterium vanbaalenii PYR-1

MVGTVEREDLGALPLAPRNPLPYRQQVRAIRTFHTGLETLRDAGGPVTRLKLAPKWLMPPMVVATSPQGA RDILARGGGHIDKTRVHHEMRRLLGANLFDLTHEPWLPRRRALQPIFTKQHVREFAGHMATAAQTVADSW
ADGTELDLDTECRKLTLRALGRSVLGLDLDEHSDAIAEPLRTALEYIADRALQPISAPRWLPTPARRRAR AASSTLHKLADKILQACRTDPTRDAPLVQALIAASDPATGRPLSDDEIRDELIVFMLAGHDTTATTLTYA
MWALGHHHDVQDRVRAEVVGIGDRELTPEDVPALGYTIQVLHEALRLCPPAAATARMAMRDVEVDGYRIE AGSMMAVGIYALHRDPALWERPLVFDPDRFSAQNSGGRDRWQYLPFGAGPRSCIGDHFAMLEATLALATI
IRSAEIRSSDPHFPMIVPFTTVAAEPIRARVKSVNRIPAADSGGR

CYP185A6 Mycobacterium vanbaalenii PYR-1

MTARDTAAAPEVGSLPLVPRNPLPLWKLVQLVRRLDTGQEVIRDAGGPITRIQLGPKKLMPPIVAVMSPA
GMRDVLGRNDASSDRCIIHEQVQEMAGDSLWVLPNEQWRPRKRALAPVFTKTSVRAFGGHMSKAAQAFVD
RWPSGGEVDLDAECRRVAMQSLGRSVLGVDLNERGETIARCMHVASSYTADRALRPVRAPRWLLTPARQR
ARSAVNAMRAITDEMVKACRDDPTRDAPLVQALIAATDPETGRPLTDEEISNDLLIFMLAGHDTTATALT
HALWVLGHHPDIQDRVAAEAAAIGDRELTPDDVPALGYTVQVLHESVRLCPPAAGVARLVTRDFAVDGYR
VEAGSLVALGLYALHHDPALWPDPMAFDPDRFSPENVKARDRWQFLPFLGGGRPCIGEHFARLETTLALA
TVVRACRIESLDDLFECEVPLTTVAKGPIRARVTPRR

CYP186A1 Mycobacterium smegmatis

MSDGGHQLRGAQALATLVDLGFPAIASGVIARRPPVLGLLERMQADERAGRR
MHRLRSEFGRGPVELVIPGRRIVVVTDPEDVAAVLVQAPEPFHPANRE
KRKALQWFQPHGVLISQGPIREQRRTVNEAALDSGAAMHRLAESFAAKVA
AEADTLVARTLPGQRLDADEFMTAWWRLVRRLTLGERARDDHAITDQLAR
LRRAGNWSFLSLPHYRARSRFLSHLYRYAEDPEPGTLVGALADVPAGGAV
DPVGQIPQWLFAFDAAGMALLRALAVLATHPLQRDRALEDAGEPNRPLLR
PYLRGCLLESVRLWPTTPAILRDTTEDTHWREGAERFTVAKGAGLLIVAP
AFHRDDQVLPFAHDFVPEIWIDGRAQLYPQLVPFSAGPAECPGRNLVLFT
TSTLAANLLNRLHFDVRSEPRPVPGEPLPMTFNHAGIEFSLRPARRAVTA
ATVDPAT

CYP186A2 Mycobacterium sp. JLS

MGASGRRLTG ARAAATLADL GPASTAARAV RRMQQLREQF GAGPVELVLP GRRMVVVLDP
DDVRRVLAGA PEPFHPANRE ERKSLEWSQR RDLDDAALDS GAEMHRLAGA FGDVIAAEAR
ELTDEVTARG TMDANQFMAA WWRIVRRIAL GDRARDDDEI TDALLRLRRA RNWSFLSMPH
YRTRARFLER LYDYVEDPQI GTLAAAVPAS GAVDPVGPLP QWLFAFDAAG IAQLRALAVL
ATHPAAMARA IEDAAEPDRL RLRPFLRACV LESVRLWPTT PTILRETTEK GAGLMIVTPA
FHRDPKLLPF ANDFVPDIWL DGRARSYPQL VPFSAGPAEC PGRNLALFTT STLLANLLSA
LDFRISSMPH LSPDEPLPVT LNQHGLEFAV VTAPRWRHHR AGSAVRS

CYP186A3 Nocardia farcinica

4523238  MSGRHPETVARDQDERSPAPVPTS
4523166  AEHGRRLDGTRAVAALTDLGFAAIAAGVIARRRPVMGLLEKAQADSRALQRMRQLRREFG  4522987
4522986  AGPVELVVPGRRIVVLLDPGDVGRVLAEAPTPFHPANREKRAALRQFQPHGVLLSKGVVR  4522807
4522806  EQRRAVNEAVLDTDAPLHRLAEPFAAIIADEAAQLMASALQRGHLDAEHFTIQWWRMVRR  4522627
4522626  LVLGERGRDDSAITDELWRLRSAANWSFLAPPHRRRREVFTEQLYRYVERPDPNSLAGAV  4522447
4522446  AAVQTGGAVDPVGQIPHWLFAFDAAGMAAQRALAVLATHPDQQAAATADAADPHQVHLRP  4522267
4522266  YLRACVLESVRLWPTTSTILRDITEPTQWRAGADAFTIAPGAALLILVPAFHRDADLLPF  4522087
4522086  ADRFAPEIWLDGQAAQYPQLVPFSAGPAECPGRNLVLFTTSTLLAHLLAAAEFRLRSGHR  4521907
4521906  MSPQTPLPLTLNNFGLDFDVTRLPNVAS*  4521820

CYP186B1 Saccharopolyspora erythraea NRRL23338

MTPKVSAALTTGVRTASPTDTARVAAQVVLPALATGVISRRPRVMALAERLRADRRAVGL
LRELRSRYGAGPLRLRVPGRDVVLVLSPEHVRRVLVSDAESFTPANREKQAALGHFQPHG
VLLSRGLDRARRRQFHEHVLETREHAHHLAPRFIQVVREEARVLLDEAERTGSLDWQTFG
AGWWRVVRRIVLGDQARDDRELTGELDALRSDANWAFLSPKRLSLRRDLRARLREHLRRA
EPGSLAETVARAETPVQAPEEQVPHWLFAFDAAGMAAFRALALLAAQPEQAARARSEIAE
SDLATPQPLHHLRACVLDALRLWPTTPMLLRDSVEETAWDGRQLPAGTAFLVFAPLFHRD
ETAADFAHAFTPEAWLDGRAEHHSALVPFSAGPGRCPGENLVLLVTSTLLAVLMRDAEFE
PGEGPALGPQGPLPATFDNFHTTVRLAR

CYP187A1 Mycobacterium smegmatis

MDSRIRDDPAVDTAALLRDPYPIFARYRAQAGVFRGSVMDWSKTPKELMP
EHQYAAMSFDAVNTVFRDGKTFNSKIYDSTIGLFIGPSILAMEGKTHRDH
RNLVSAAFKSKSLARWEPEIARPICEALVDEFVDTGSADLVRDYTFEFPT
RVISKLLGLPEEDLPWFRRRAVELISYSVKYKRAFEASAALKDYFLDQIE
RRRSRPTEDIIGDLVTAEIDGEKLTDEAIYSFLRLLLPAGLETTYRSSGN
LLYLLLTHPDQFAAVQNDHDLIGAAIEEGLRYETPLTTVQRSATKDTELE
GVQIPAGAVIDVCIGSANRDENRWERPEEFDIFRKRIPHITFAAGEHTCM
GLHLARMETRVAMETLLNRVTDLRLIADDDPHIFGQPFRSPTAIPVTFRPAG

CYP187A2 Mycobacterium avium subsp. Paratuberculosis old 273A1X

MMTNVPTAAGDETVSLRDPYPFFARKRREAGVFAGTVMDYSKTP
ESLMPKQEYSAVSFDAVNTVFRDGRVFSSKPYDKTIGLFMGPTILAMEGKKHRDHRNL
VSAAFKSKALARWEPTIVRPICNALIDDFIDAGTADLVRQFTFEFPTRVIARLLGLPD
EDLPMFHTRAVQLISYHVDYERAFEASAALKDYFLEQIEQRKSKPTEDIIGDLVTAEI
DGEKLSDEAIYSFLRLLLPAGLETTYRSSGNLLYLLLTHPDQFAALQADRELLAPAIE
EGLRFETPLTTVQRFTTEDTELQGVRIPARSVIGVCIGSANRDERRWERSEEFDIFRK
HVPHISFAAGEHTCLGLHLARLETRVAMECLLNRLTNVTLLSDGDPHIHGQPFRSPTA
LPVTFDAK

CYP187A3 Mycobacterium avium subsp. Paratuberculosis old 273A2X

MPLSTGPTGQPVVPTLDFTGETSPYPFFEHMRRTDPVWHGSLAD
ASQLPEELRPEDEWVLFDYESVSQAFRDDRIFSSHKYDETIGLVMGHTILAMGGREHH
DHRNLVAKAFRATALERWEPSVIGPVCEQLVDEIKNDGHADLVKAVTFEFPTRIISTL
LGLPAEDLDLFRRLSLDLISIPTDIEAGLNAATELYDYFLKQVEQRRRKPTDDIIGDL
VAAEIDGEKLTDEAIIAFLRLLLPGGLETTYRSSGNLLYLLLTHPEQLAMVYRDRSLI
PMAIEEGLRFETPLTMVTRTTTEEVEIGGKTIPANAQIDMCMGSANRDETRWTDPNAF
DIRRPRQAHIAFAGGIHMCLGMHLARLETRVMLNSLFDRVRDLAFVPDDGTGEESKIV
GLTFRSPNKLPVTFAPAA

CYP187A4 Mycobacterium marinum MM3996 old CYP273A3X

MTLRTDADGQ PVTLDLTGET SPYPFFEYMR RTDPVWHGAL MDHGQMPEEL RPNDEWVLFG
YDGVFQAFRD DRIFTSAGYD KTIGLVMGHT ILAMGGREHH DHRSLVAKAF RATALERWEP
SVIGPVCDQL IDEIRADGHA DLVKALTFEF PTRIISTLLG LPREDLDLFR RLSFDLISIP
TDIVAGFNAA TELHGYFLDQ VEQRRRKLTD DIIGDLVAAE IDGEKLDDEA IIAFLRLLLP
AGLETTYRSS GNLLYLLLTH PEQLAMVQRD RSLIPIAIEE GLRFETPLTM VMRTTTEEVD
IGGKTIPPDA QIDLCMGSAN RDESRWPDPN RFDIRRTRHA HIAFAGGIHM CLGMHLARLE
TRVMLNSLFD RVTNLAFTPD DGTGVQSRII GLTFRSPNKL PVTFTPAA*