P450s that have appeared since the 1993 P450 nomenclature update.
Part C covering CYP10 to CYP69
Animal P450 names continue at CYP301 in this file
Lower eukaryote names continue at CYP501-699 in this file
Lower eukaryote names have used up all 3 digit names and now
Continue at CYP5001.
ALL Drosophila melanogaster P450S ARE NOW INCLUDED
This includes list references that were incomplete and duplications of
sequences that were already in the update. If a sequence is assigned an
accession number that was not in the old update it is included in this list.
Some expressed sequence tags (ESTs) are also included from humans.
This list last revised Aug. 24, 2009 (adding in all new fungal CYP names)
This list was last revised on Dec. 31, 2007.
Added all Neurospora P450s see 527A1-553A1
Added CYP51 Trypanosoma brucei
Added Fugu P450s, added CYP505A3 added CYP18 Spodoptera
Added all human genes and pseudogenes
Added 104 Anopheles genes
Revised May 13, 2003 named all remaining Dictyostelium P450 genes
Many sequences have been added without updating this list (May 11, 2005)
Added names for Nectria haematococca (158 genes/pseudogenes) Feb. 16, 2006
Added all Phanerochaete chrysosporium (white rot fungi) genes Aug. 29, 2007
Revised Jun 22, 2010
Compiled by David R. Nelson
There are 80 C. elegans P450s listed here, surpassing the known mouse and human
complements. The C. elegans genome is now about 90% finished sequence and 9%
unfinished (one strand or one chemistry). About 1Mb is not cloned at three
telomeres and two internal sites. A special issue of Science appeared in Dec. 98 even though the genome is not completely done. The amount of sequence in the Blast searchable database at Washington Univ. is 140Mb, more than the 100Mb size of the genome. Therefore, we can guess that this set includes all the P450 genes in C. elegans, but the distrubution is not even. Most P450 genes (43 genes) are on chromosome V. see additional info on C. elegans P450s see this list. To see the actual sequences go to the C. elegans sequence file. So far we are missing CYP11A, CYP11B, CYP17, CYP19, CYP21, CYP24 and CYP27A and CYP27B. Does C. elegans make steroids? The present evidence would suggest not. Does C. elegans have
mitochondrial P450s? There is one probable mitochondrial P450 in C. elegans on
cosmid ZK177 named CYP44. It was thought to be incomplete but now a full length sequence
has been assembled from the genomic sequence.
10A Subfamily
11A Subfamily
11B Subfamily
12A Subfamily
12B Subfamily
13A Subfamily
13B Subfamily
14A Subfamily
16A Subfamily
17A Subfamily
18A Subfamily
19A Subfamily
21A Subfamily
22A Subfamily
23A Subfamily
24A Subfamily
25A Subfamily
26A Subfamily
27A Subfamily
27B Subfamily
28A Subfamily
29A Subfamily
30A Subfamily
31A Subfamily
32A Subfamily
33A Subfamily
33B Subfamily
33C Subfamily
33D Subfamily
33E Subfamily
34A Subfamily
35A Subfamily
35B Subfamily
35C Subfamily
35D Subfamily
36A Subfamily
37A Subfamily
37B Subfamily
40A Subfamily
41A Subfamily
42A Subfamily
43A Subfamily
44A Subfamily
45A Subfamily
46A Subfamily
51A Subfamily
52A Subfamily
52B Subfamily
52C Subfamily
52D Subfamily
52E Subfamily
52F Subfamily
53A Subfamily
53B Subfamily
54A Subfamily
55A Subfamily
56A Subfamily
57A Subfamily
58A Subfamily
59A Subfamily
60A Subfamily
60B Subfamily
61A Subfamily
62A Subfamily
63A Subfamily
64A Subfamily
65A Subfamily
66A Subfamily
67A Subfamily
10A Subfamily
CYP10A1 Lymnaea stagnalis (pond snail)
GenEMBL S46130 (1870bp) PIR JX0225 (545 amino acids)
AAB23599.1
Teunissen,Y., Geraerts,W.P., van Heerikhuizen,H., Planta,R.J.
and Joosse,J.
Molecular cloning of a cDNA encoding a member of a novel
cytochrome P450 family in the mollusc Lymnaea stagnalis.
J. Biochem. 112, 249-252 (1992)
Mitochondrial clan
1 MAIMKKFIHH SLKQLIKPNL TSTKRVVSTS PRKEQGVAAI SLEPSEMAQC PFRKSIDTFT
61 ETTNAVKAPG MTEVQPFERI PGPKGLPIVG TLFDYFKKDG PKFSKMFEVY RQRALEFGNI
121 YYEKVGHFHC VVISSPGEYS RLVHAERQYP NRREMVPIAY YRKQKGFDLG VVNSQGEEWY
181 RQRTVVSKKM LKLAEVSNFS TQMGEVSDDF VKRLSHVRDS HGEIPALERE LFKWAMESIG
241 TFLFEERIGC LGQETSPMAQ TFIANLEGFF KTLQPLMYNL PTYKLWSTKL WKQFENYSDN
301 VIDIGRSLVE KKWHPCKMEV TQNLHLISYL VNNGSMSTKE VTGLIVDLML AAVETTSSAT
361 VWCLYNLAKN PQVQEKLFQE ITEAQAKNNG TISAEDLCKL PMVKAVVKET LRLYPITYST
421 SRNIAEDMEL GGYTIPAGTH VQANLYGMYR DPSLFPEPEG ILPERWLRMN GSQMDATIKS
481 TSQLVWGHGA RMCLGRRIAE QEMHITLSKI IQNFTLSYNH DDVEPILNTM LTPDRPVRIE
541 FKPRQ
CYP10A2 Biomphalaria glabrata (bloodfluke planorb, carries schistosomiasis)
ESTs EV821686, EV821681, EV817279
Probable mitochondrial P450
LFDYFKKDGPRFNKI
FQVQQQRSAQYGEIYYEKIADFESVIESSPEEYNRLERSEGKYPCRREMA
PMAYYNRKKGYALGIVNSQGKDWYNLRTVVSKKMLKLSEVS
YGMFHNPDYFPEPETFLPERWLKENKMDATIKSASQLVWGHGARMCLGRRLAEQELHI
TIAKIIENFQLNYHGDEVQPILNTTMVPDRPVNIQFSRRQISKDTVFNNTH*
CYP10A3 Lottia gigantea (owl limpet)
JGI Protein ID:233081
53% to CYP10A1
MSSLIPKTFAKIAVTALPEIATKRVVSTSVAHKQSARVIEVDPLTLGTC
PFRSTFEKVESIVNPIEPKVEPQELTKETGIKSFEHVPGPK
GLPILGSLLDYFKKDGLRFDK
MFEAFKVRSIEFGPVYK
ESIGPIDTVVISDPAEYAKVIRADGKFPNRKEMEPMAF
YREQKGIGLGLVNSQGEEWHRQRSAVIKKML
MLNEVQDFSQPMNVVANDFITHLSSSRDASGE
IQQLDKQIFKWAMESIGTFLFEERIGCLNEK
PTELAQEFIDTLQKYFRLMQQLMYNLPMYKVFRTKKWQEFEK
LSDRIMEVGREFVDKKIE
KLQNADPSTSQEKGAFLTHLISQKS
LSTSDVTSNAVDLLSAAVETTSNASLWCLYNLATN
PEAQQTMFNEINTVLPNKEDVTPQALSKLPYVKAVLK
ETFRKYPITYATSRFLPENLEVGGYNIPAG
THVQANLYGMYSD
AKIFPEPEKFKPERWLRESKMDSQT
KSLSNLIWGHGARMCIGRRFAEQEMHIMLTK
IIQNFKLEYHHEPVEPTLNT
VMTPDRPVQIKFVPRS
CYP10B1 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:143013
46% to CYP10A1
MKGGQVVRKEKKLKPFKDIPGPKG
LPVIGTLLEFTKKDGLKFNK
MFEVMTSRSKEFGPVYK
ERIGMIESVIVSDPHEYAKVIQVDGKHPHRIELFPMVH
YRQKKKMALGTVNAQGEEWYRGRMVLSKVML
KPKEVQDYVIAQSDVGNDFIRHMKSIVSSDGQ
LISFEREIFKWALESICVVLFEERIGCFPNP
PTEKAQEFITNLIGFFKYMQPLMYNFPMYKIYPTKTWRQYEK
HGDIVVGIG
LDMVRKVKKESKSEFLTYLLAQKS
LSPVEANSHAVDLMMGAVETTANSMMWMLYCLSNF
PDAQRKLQEEIDKIVPQDERITPEVLSKMKYTKACLK
ETFRLFPITFATSRMIHEEIELGGYHIPKG
THCQANLWGMGRD
PDYFSDPLTFKPERWLRDIQTLEHH
NPHAVLPFGHGARMCIGLRFAEQEIYIAVAK
LMKHFTVKHEGELLPVLNT
VMTPDRPVNFRFLLRTKPALSGLGDTKKPIAVELK
CYP10B2 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:134490
87% to CYP10B1, 47% to CYP10A1
KLKPFKDTPGPK
GLPVIGTLLEFTKKDGLKFNK
MFEVMTSRSKEFGSVYK
ERIGFLESVIVSDPDEYTKVIKVDGKYPHRIEMLPMVH
YRQKKKMALGTVNAQGEEWYRARMVLSKVML
KPKEVQEYVIAQSDVGNDFIKHMKSIASNDGQLLN
FEREIFKWALESICVVLFEERIGCFPNP
PTERAQEFIANLIGFFKYMQPLMYNLPVYKIYPTKTWRKYEK
HGDTVFGIGLDMV
TKVFLPGEKESKSEFLTYLLAQKS
LSPVEANSHAVDLMIGAVETTANSMMWMLYCLSNF
PEVQRKLQDEIDATLPQDEHITPEILSRLKYTRACLK
ETFRLYPVTFATSRMIHKDIELGGYHIPKG
THCQANLWGMGRD
PDYFSDPLTFKPERWQRDTQTLEYH
NPHAVLPFGHGARMCIGRRFAEQEIYIAVAK
LMKHFTVEHVGHLHPILIT
VMIPDRPVNFRFRPRTKPER
CYP10C1 Helobdella robusta (leech, annelid worm)
JGI Protein ID:67702
48% to CYP10B2, 41% to CYP10A1
MRKYIIQIISRNKIHNFNNYDRIGNNILKV
NCVSTSAAAFDNTDLLVSNANVLTENKLAELKSFESLPGPK
GLPLFGTLLSYVRPGGLSFRK
MFKVMDMRAKQYGSVYK
ETIGSNLTSVIVSDMEEYLKVIRADGKMPNRIELEPFKY
FRERNNFDIGIVNSQGLQWLEKRQILGPKIM
ALSEILDHVGPINDVTMDFLKRMDEKLLDRDGLFK
NLERNLFTWALEAVGTYLFEARIGCLNEP
IPPFADMFITHLSGMFREMQGLMYGPPIYKYISTRNWKRFED
HCYKIM
EAGMTLIEETSSSSALLTFLLSQKS
MSASSVNLTSIDVMIGAIETTSNSFTWMLYCLARN
PEVQEKLFEEVLQYLPNKDSPVTREVIRKMDYVRACLK
ETLRFYPITFATSRKLASEIELKGFRIPKG
THVQANLWTIGRD
ERLFPHPEKFNPDRWLRKSHEVSHLA
TALSHLPFGHGPRMCIGQRLAEMEIYTMVSK
LIRNFKVECAEKGEVQPILMT
VLTPDRPMMLKFKRR
11A Subfamily
CYP11A1 human
PIR A48733 (239 amino acids)
Matteson, K.J., Chung, B.C., Urdea, M.S. and Miller, W.L.
Study of cholesterol side-chain cleavage (20,22 desmolase)
deficiency causing congenital lipoid adrenal hyperplasia
using bovine-sequence P450scc oligodeoxyribonucleotide
probes.
Endocrinology 118, 1296-1305 (1986)
CYP11A1 human
GenEMBL M14565
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL. (1986)
Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning,
assignment of the gene to chromosome 15, and expression in the
placenta. Proc Natl Acad Sci U S A. 83, 8962-8966.
First complete human CYP11A1 cDNA
CYP11A1 Pan troglodytes (chimp)
AK304902
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRS PRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA PEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGER QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK ADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT LQWHLYEMARNLKVQDMLRAEVLAARRQAQGDMATMLQLVPLLKASIKETLRLHPISV TLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNVTYF RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS
FTFWPFNQEATQQ
CYP11A1 Papio hamadryas ursinus (chacma baboon)
AY702067
MLAKGLPPRSVLVKGCQTFLSAPKERLGHLRVPTSERAGISTRS
PRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVI
DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA
PETTKNFLPLLDAVSRDFVSVLHRRIKKAGSGNFSGDISDDLFRFAFESITNVIFGER
QGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSK
ADMYTENFYWELRQKGNVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT
LQWHLYEMARNLKVQDMLRAEVLAARRQAQGDMATMLQLVPLLKASIKETLRLHPISV
TLQRYLVNDLVLRGYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYF
RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS
FTFWPFNQEATQQ
CYP11A1 Macaca fasicularis (cynomolgus monkey)
DQ228169
MLAKGLPPRSVLVKGCQTFLSAPKERLGHLRVPTSEGAGISTRS
PRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYDPIYREKLGNVESVYVI
DPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMA
PETTKNFLPLLDAVSRDFVSVLHRRIKKAGSGNFSGDISDDLFRFAFESITNVIFGER
QGMLEEVVNPEGQRFIDAIYQMFHTSVHMLNLPPDLFRLFRTKTWKDHVAPRDVIFSK
ADMYTENFHWELRQKGNVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMT
LQWHLYEMARNLKVQDMLRAEVLAARRQAQGDMATILQLVPLLKASIKETLRLHPISV
TLQRYLVNDLVLRGYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYF
RNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPIS
FTFWPFNQEATQE
CYP11A1 rabbit
GenEMBL S59219 (1336bp) PIR A49189 (445 amino acids)
Yang,X., Iwamoto,K., Wang,M., Artwhol,J., Mason,J.I. and
Pang,S.
Inherited congenital adrenal hyperplasia in the rabbit is caused by
a deletion in the gene encoding cytochrome P450 cholesterol side
chain cleavage enzyme.
Endocrinol. 132, 1977-1982 (1993)
CYP11A1 bovine
PIR A42033 (18 amino acids)
Pikuleva, I.A., Lapko, A.G., Chashchin, V.L.
Functional reconstitution of cytochrome P-450-scc with hemin
activated with Woodward's reagent K. Formation of a
hemeprotein cross-link.
J. Biol. Chem. 267, 1438-1442 (1992)
CYP11A1 Bos taurus (cow)
See cattle page for details
MLARGLPLRSALVKACPPI
LSTVGEGWGHHRVGTGEGAGISTKTPRPYSEIPSPGDNGWLNLYHFWREKGSQRIHFRHI
ENFQKYGPIYREKLGNLESVYIIHPEDVAHLFKFEGSYPERYDIPPWLAYHRYYQKPIGV
LFKKSGTWKKDRVVLNTEVMAPEAIKNFIPLLNPVSQDFVSLLHKRIKQQGSGKFVGDIK
EDLFHFAFESITNVMFGERLGMLEETVNPEAQKFIDAVYKMFHTSVPLLNVPPELYRLFR
TKTWRDHVAAWDTIFNKAEKYTEIFYQDLRRKTEFRNYPGILYCLLKSEKMLLEDVKANI
TEMLAGGVNTTSMTLQWHLYEMARSLNVQEMLREEVLNARRQAEGDISKMLQMVPLLKAS
IKETLRLHPISVTLQRYPESDLVLQDYLIPAKTLVQVAIYAMGRDPAFFSSPDKFDPTRW
LSKDKDLIHFRNLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVEMQHIGDVDTIFNLI
LTPDKPIFLVFRPFNQDPPQA*
CYP11A1 Sus scrofa (pig)
GenEMBL X13768 (see also NM_214427)
Mulheron GW, Stone RT, Miller WL, Wise T. (1989)
Nucleotide sequence of cytochrome P-450 cholesterol side-chain
cleavage cDNA isolated from porcine testis.
Nucleic Acids Res. 17, 1773
CYP11A1 Sus scrofa (pig)
GenEMBL L34259 (2376bp), NM_214427
Urban,R.J., Shupnik,M.A. and Bodenburg,Y.H.
Insulin-like growth factor-I increases expression of the porcine
P-450 cholesterol side chain cleavage gene through a GC-rich domain.
J. Biol. Chem. 269, 25761-25769 (1994)
MLARGLALRSVLVKGCQPFLSAPRECPGHPRVGTGEGACISTKT
PRPFSEIPSPGDNGWINLYRFWKEKGTQKIHYHHVQNFQKYGPIYREKLGNLESVYII
DPEDVALLFKFEGPNPERYNIPPWVAYHQHYQKPVGVLLKKSGAWKKDRLVLNTEVMA
PEAIKNFIPLLDTVSQDFVGVLHRRIKQQGSGKFSGDIREDLFRFAFESITNVIFGER
LGMLEEIVDPEAQKFIDAVYQMFHTSVPMLNLPPDLFRLFRTKTWRDHVAAWDTIFNK
AEKYTQNFYWDLRRKREFNNYPGILYRLLGNDKLLSEDVKANVTEMLAGGVDTTSMTL
QWHLYEMARSLNVQEMLREEVLNARRQAQGDTSKMLQLVPLLKASIKETLRLHPISVT
LQRYLVNDLVLRDYMIPAKTLVQVAVYAMGRDPAFFSNPGQFDPTRWLGKERDLIHFR
NLGFGWGVRQCVGRRIAELEMTLFLIHILENFKVELQHFSDVDTIFNLILMPDKPIFL
VFRPFNQDPLQA
CYP11A1 Equus caballus (horse)
NM_001082521
MLVRGLPLRSVLVKGCQPLLSAPREGPGHPRVPTGEGAGMSSHS
PRPFKEIPSPGDNGWINLYHFWREKGPKKLHYHHFQNFQKYGPIYREKLGNVESVYIV
DPEDVALLFKFEGPHPERFLIPPWTAYHQYFQKPVGVLFKSSDAWKKDRLALNPEVMA
LESIKNFIPLLDPVSQDFVSLLHRRMEQQGSGKFSGPIIEDLFRFAFESITNVIFGER
QGMLDEIVDPEAQRFIDAVYKMFHTSVPMLSLPPDLFRLFRTKTWRDHVAAWDTVFSK
AEQYTEKFYQDLKQKRHFDSYPGIFYRLLASNKLPFKDIQANVTEMLAGGVDTTSMSL
QWHLYEIARNLRVQEMLREEVLAARRQAQGDTSTMVQMVPLLKASIKETLRLHPIAVT
LQRYPQNDLVIRDYMIPAKTLVQVSIYTMGQDPTFFSNPRRFDPTRWLDKNKDLTHFR
NLGFGWGVRQCLGRRIAELEMTLFLIHILENFRVEIQHLNDVDSTFGLILIPEKPISF
TFWPITRAPPQA
CYP11A1 goat
GenEMBL D50058 (1825bp)
Okuyama,E., Okazaki,T., Furukawa,A., Wu,R.-F. and Ichikawa,Y.
Molecular cloning and nucleotide sequences of cDNA clones of sheep
and goat
adrenolcortical cytochrome P450scc.
unpublished (1995)
CYP11A1 sheep
GenEMBL D50057 (1825bp)
Okuyama,E., Okazaki,T., Furukawa,A., Wu,R.-F. and Ichikawa,Y.
Molecular cloning and nucleotide sequences of cDNA clones of sheep
and goat
adrenolcortical cytochrome P450scc.
unpublished (1995)
CYP11A1 bovine
PIR S29644 (21 amino acids)
Tsujita, M. and Ichikawa, Y.
Substrate-binding region of cytochrome P-450(scc) (P-450
XIA1). Identification and primary structure of the
cholesterol binding region in cytochrome P-450(scc).
Biochim. Biophys. Acta 1161, 124-130 (1993)
CYP11A1 Canis familiaris (dog)
XM_535539.2,
79% to CYP11A1 human
MLAKGLPLRSVLVKGCQPFLSTVWEGPGHPRVPTGDGASISTQI
PRPFSEIPTPGNNGWLNLYNFWREMGSQKIHYHQVQNFQKYGPIYREKLGSVESVYII
DPEDVALLFKFEGPTPERFCIPPWVAYHQYHQRPVGVLLKKSGAWKKDRLALNQEVMA
PEAIKNFIPLLDPVSQDFVKVLHRRIKQQGSGKFSGDISDDLFRFAFESITNVMFGER
LGMLEERVDPEAQRFIDAVYQMFHTSVPMLTFPPDLFRLFKTKTWRDHVAAWDVIFNK
AEIYTQNFYWELRQKRDVDNYPGILHRLLKSNKLLFEDVKANITEMLAGGVDTTSMTL
QWHLYEMARSLEVQEVLREEVLAARRQAQGNVSTMLQLVPLLKASIKETLRLHPISVT
LQRYLENDLVLRNYMIPAKTLVQVSTYAMGQDPTFFLNPSKFDPTRWLGKDKELIHFR
NLGFGWGVRQCVGRRIAELEMTLFLIHILENFRVEMQQLRDVGTTFNLILMPDKPIFL
TFRPFNQGPPQV
Cyp11a1 mouse
GenEMBL J05511, NM_019779, AF195119
Rice,D.A., Kirkman,M.S., Aitkin,L.D., Mouw,A.R., Schimmer,B.P. and
Parker,K.L.
Analysis of the promoter region of the gene encoding mouse
cholesterol side-chain cleavage enzyme
J. Biol. Chem. 265, 11713-11720 (1990)
MLAKGLSLRSVLVKGCQPFLSPTWQGPVLSTGKGAGTSTSSPRS
FNEIPSPGDNGWLNLYHFWRESGTQKIHYHQMQSFQKYGPIYREKLGTLESVYIVDPK
DASILFSCEGPNPERFLVPPWVAYHQYYQRPIGVLFKSSDAWKKDRIVLNQEVMAPGA
IKNFVPLLEGVAQDFIKVLHRRIKQQNSGNFSGVISDDLFRFSFESISSVIFGERMGM
LEEIVDPEAQRFINAVYQMFHTSVPMLNLPPDFFRLLRTKTWKDHAAAWDVIFNKADE
YTQNFYWDLRQKRDFSQYPGVLYSLLGGNKLPFKNIQANITEMLAGGVDTTSMTLQWN
LYEMAHNLKVQEMLRAEVLAARRQAQGDMAKMVQLVPLLKASIKETLRLHPISVTLQR
YTVNDLVLRNYKIPAKTLVQVASFAMGRDPGFFPNPNKFDPTRWLEKSQNTTHFRYLG
FGWGVRQCLGRRIAELEMTILLINLLENFRIEVQNLRDVGTKFSLILMPENPILFNFQ
PLKQDLGPAVTRKDNTVN
CYP11A1 Gallus gallus (chicken)
NM_001001756
MLSRAAPIAGSFQACRCAGGIPALAGVHYPLPSSSGARPFDQVP
GEWRAGWLNLYHFWKEGGFHNVHNIMASKFQRFGPIYREKLGVYESVNIISPRDAATL
FKSEGMLPERFSVPPWVAYRDYRNKPYGVLLKTGEAWRSDRLTLNKEVLSPQVVDSFV
PLLDQVSQDFLRRARAQVQQSGRERWTADFSHELFRFALESVCHVLYGERLGLLQDFV
DPEAQQFIDAVTLMFHTTSPMLYVPPALLRHLNTKTWRDHVHAWDAIFTQADKCIQNV
YRDIRLQRKSTEEHTGILFSLLVQDKLPLDDIKASVTEMMAGGVDTTSMTLQWAMLEL
ARSPGIQERLRAEVLAAKQEAQGDRVKMLKSIRLLKAAIKETLRLHPVAVTLQRYTTQ
EVILQDYRIPPKTLVQVGLYAMGRDPEVFPKPEQFNPERWLVMGSKHFKGLSFGFGPR
QCLGRRIAELEMQLFLMHILENFKIETKRAVEVGTKFDLILVPEKPIYLRLRPLQPQE
CYP11A1 Taeniopygia guttata (zebrafinch)
NP_001120846 NM_001127374
76% to CYP11A1 Gallus gallus (chicken)
chrUn:142405603-142406467 frag 1 and 2 below
chrUn:111324326-111324517 frag 3 below
MLARVVTKPGALRGCPRGAAARCRRLGGAGGAVPSAPRPFNQVPGEWRAG
WLNLYRFWREGGLSALHLSMAQKFRRFGPIYREKLGVHETVNIISPGDAA
TLFQAEGALPERFRVPPWVAYRDFRNKPYGVLLKTGEAWRSDRLLLNQEA
LAPAAVAAFVPLLSAVGEDFVRRARAQARHSGHGCWTGDFSHELFRFALE
SVCHVLYGQRLGLLQDFVQPEAQRFIEAVARMFHTTAPMLYLPPALLRRL
RSRTWREHVHAWDAIFCQADKCIQNVYRDLRLQRKSSQEYMGILGNLILR
DKLPLDDIRASVTEMMAGGVDTTSMTLQWAMLELARAPGVQEQLRAEVLA
AKREAGGDREKMLKSTRLLKATIKETLRLHPVAVTLQRYTTHEVILQDYR
IPPGTLVQVGLYAMGRDPDVFPRPERFRPQRWLAAGPKPFLGLGFGFGPR
QCLGRRIAELEMQLFLMHILENFKIETMRAVEIGTKFDLILIPDQPIQLT
LRPLDGQP
CYP11-like fragments from zebrafinch genome
60% to CYP11B1 human, 56% to CYP11A1 human
Note: 11A1 gene is mostly missing from the genome assembly in zebrafinch
and these seqs match the known mRNA for CYP11A1
1. ADKCIQNVYRDLRLQRKSSQEYMGILGNLILRDKLPLDDIRASVTEMMAGGVDT
2. RLHPVAVTLQRYTTHEVILQDYRIPPG
3. TLVQVGLYAMGRDPDVFPRPERFRPQRWLAAGPKPFLGLGFGFGPRQCLGRRIAELEMQLFLMHV
CYP11A1 Alligator mississippiensis (American alligator)
DQ007995
VNIINPEDAATLFKSEGMFPERFTVSPWVAYRDHRNKSYGVLLK
NGEAWRFDRLILNKEVLSPQVMDNFVPLLNEVGEDFVRRVRVQIEKSGRGKWTADFTN
ELFRFALESVCHVLYGERLGLLQDFVDPEAQRFIDAVSMMFHTTSPMLYIPVKLFHWI
NSKTWQDHVKAWDVIFMQADKCIQNVYRDLRLQRK
CYP11A1 Xenopus tropicalis
CX377330.2 CX940317 cannot extend in ESTdb
22200_prot scaffold_62:97483-110117 model short at N-term
53% to CYP11A1 human 62% to 11A1 Fugu
propose a GC boundary at the end exon 1 to preserve length
MLLLRRLPAVPSGLRMISHHSVVGAGPEMGTLSQVD
TPLPYNQMPGNWKRGWLELYRFWRKDGFHNIHYHMMENFQRFGPIYR (2)
EALGIYDSVFIQLPEDAATLFHVEGLH
PERLRVPPWYEYRDYRNRRYGVLLKKGEDWRSHRIALNREVLSMSAMSRF
LPLLDSVGQDFVHRAHIQVERSGRGKWTADLTNELFRFALESVCYVLYGQ
RLGLLQDYIDPESQQFIDSVSLMFNTTAPMLYLPPSLLRKINSSIWKDHV
RAWDAIFTHADRCIQQIYSSLRQQSDSTYSGVLSSLLLQDQMPLEDIKAS
VTELMAGGVDTTSMTLQWAMYELARTPSVQEKLRSEVIAARDASGKDLTA
LLKRIPLVKAALKETLRLHPVAITLQRYTQRDTVIRNYIIPQGTLVQVGL
YAMGRNPDIFALPQRFSPERWLGGGPTHFRGLGFGFGPRQCIGRRIAEIE
MQLFLIHILENFKIEINRMVDVGTTFNLILFPSKPIHLTLRPLK*
CYP11A1 Xenopus laevis (African clawed frog)
ESTs CK799174.1 DR729422.1 DR729360.1 CN322906.1
FRRLPAVPSGLRLLSHHPVVAETPEMGTLSQVETPLPYNQMPGNWKRGWLELYRFWRKDG
FHNLHYHMMENFQRFGPIYREALGIYDSVFIQLPEDAATLFHVEGLHPERLRVPPWYEYR
DYRNRRYGVLLKSGEDWRSHRISLNHEVLSVSAMSRFLPLLDSVGQDFVRRAHIQVERSG
RGKWTADLTNELFRFALESVCYVLYGQRLGLLXDYIDPESQQFIDSVTLMFHTTAPMLYL
PPSLLRKINSSILKDHVRAWDAIFTHADRCIQQIYSSLRQHSDSTYSGVLCSLLLQ
DQMPLEDIKASVTELMAGGVDTTSMTLQWXXXXXXXXXXXXXXXXXXX
AAREISGGDLTAF*RESPIVKAALKETLRLHPVAITLQRYTQRDTVIRNYMIPQGTLVQV
GLYAMGRNPDIFASPQRFSPERWLGGEPTHFRGLGFGFGPRQCIGRRIAEMEMQLFLIHI
LENFKIEINRMVDIGTTFNLILFPSKPILLTLRPLK*
CYP11A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP11A1 Oncorhynchus mykiss (rainbow trout)
GenEMBL S57305 (1789bp) Swiss Q07217 (514 amino acids)
PIR S32197 (514 amino acids)
Takahashi,M., Tanaka,M., Sakai,N., Adachi,S., Miller,W.L.
and Nagahama,Y.
Rainbow trout ovarian cholesterol side-chain cleavage
cytochrome P450 (P450scc). cDNA cloning and mRNA expression
during oogenesis.
FEBS Lett. 319, 45-48 (1993)
CYP11A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_1630
82% to 11A1 trout, GC boundary at GIFNQ
note: intron exon boundaries are the same for CYP11A, B and C
37515 MARWSVWRSPVVLPLSRMEVPMTGARHSSTMPVARQTYSDSSSFV 37381
37380 RSFNDIPGLWKNGVANLYNFWKLDGFRNLHHIMVQNFNTFGPIYR 37246 (2)
37065 EKIGYYESVNIINPEDAAILFKAEGHYPKRLKVEAWTSYRDYRNRKYGVLLK 36904 (2)
36822 NGEEWRCNRVLLNKEVISPKVLENFVPLLDEVGNDFVVRVHKKIARSGQNKWTTDLSQELFKYALE 36631 (1)
36509 SVSSVLYGERLGLFLDYIDPEAQHFIDCISLMFKTTSPML
YIPPALLRKVGAKVWRDHVEAWDGIFNQ 36300 (1)
36208 ADRCIQNIYRRLRQETGPSKKYPGVLASLLLRDKLSIEDIKASITELMAGGVDT 36047 (0)
35975 TSITLLWTLYELARHPNLQEELRAEVAAARTESQGDMLEMLKRIPLVKGALKETLR 35808 (2)
35731 LHPVAVSLQRYIAEDIIIQNYHIPAG 35654 (0)
35568 TLVQLGLYAMGRDPKVFFRPEQYQPSRWLRSETHYFKSLGFGFGPRQCLGRRIAEAEMQLFLIH 35377 (0)
35297 MLENFRVEKQRHMEVQSTFELILLPDKPIILTLKPLSS* 35181
CYP11A1 Tetraodon nigroviridis (Green puffer)
93% to CYP11A1 fugu
MVRQAYSDSSGFVRSFNEIPGLWKNGVANLYNFWKLDGFRNLHRIMVQNFNTFGPIYRE
KIGYYESVNIINPEDAAILFKAEGHYPRRLNVEAWTSYRDYRNRKYGVLLKNGEDWRSN
RVILNKEVISPKVLANFVPLLDEVGEDFVARVHKKIARSGQNKWSTDLSQELFKYALES
VSSVLYGERLGLLLDYIDPEAQHFIDSISLMFKTTSPMLYIPPALLKQLGAKVWRDHVE
AWDGIFNQADRCIQNIYRRLRQETGPSKPYPGVLASLLLLDKLSIEDIKASITELMAGG
VDTTSITLLWTLYELARHPNFQEELRAEVAAARAASQGDMLEMLKRIPLVKGALKETLR
LHPVAVSLQRYIAEDIIIQNYHIPAGTLVQLGLYAMGRDPKVFFRPEQYQPSRWLRTEK
HYFKSLGFGFGPRQCLGRRIAETEMQIFLIHMLENFRVEKPRHVEVQSTFELILLPDKP
IILTLKPLS
CYP11A1 Dasyatis americana (southern stingray)
GenEMBL U63299(4619bp)
Nunez,B.S. and Trant,J.M.
Isolation of the cDNA encoding the interrenal form of cholesterol
side chain cleavage cytochrome P450 of the southern stingray
(Dasyatis americana).
unpublished (1996)
CYP11A2 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP11A2 Fundulus heteroclitus (mummichog)
AB471800
78% to zebrafish CYP11A2, only 67% to zebrafisn CYP11A1
MARLSMWRSPGTLALSWMEEQVASGVRSSSSMPAIRQAYPESGG
SSSSSIVRPFAEIPGLWKNGVVNLYNFWKLDGFKNLHRIMLQNFNTFGPIYREKIGYY
ESVNIIKPEDAAILFKAEGQYPKRLQVEAWTSYRDYRNRKYGVLLKNGEDWRSNRVIL
NKEVISLKMLENFVPLLDDVGQDFVTRVHKKIKRSGQNKWTTDLSQELFKYALESVGS
VLYGERLGLMLDYIDPEAQRFIDCITLMFKTTSPMLYIPPALLRQVGAKVWRDHVEAW
DGIFNQADRCIQNIYRQLRQEAGTSKEYPGVLASLLLLDKLSIEDIKASVTELMAGGV
DTTSITLLWTLYELARHPSLQEELRAEVAAARAASQGDMQDMLKRIPLVKGALKETLR
LHPVAVSLQRYIAEDIIIQNYHIPAGTLVQLGLYAMGRDPKVFFRPEQYLPSRWLRTE
TQYFRSLGFGFGPRQCLGRRIAETEMQIFLIHMLENFRIEKQRNVEVQSTFELILLPD
KPIILTLKPLQGSQ
11B Subfamily
CYP11B1 human
GenEMBL J05140 M32863 (1482bp) M32878 (2633bp) M32879 (1155bp)
Mornet,E., Dupont,J., Vitek,A. and White,P.C.
Characterization of two genes encoding human steroid 11-beta-
hydroxylase (P-450-11-beta).
J. Biol. Chem. 264, 20961-20967 (1989)
CYP11B1 human
GenEMBL D16155 (156bp)
Naiki,Y., Shizuta,Y., Kawamoto,T., Yasushiro,M., Miyahara,K.,
Toda,K., Tadao,O. and Imura,H.
A nonsense mutation (TGG(116Arg)-TAG(stop)) in CYP11B1
causes steroid 11beta-hydroxylase deficiency.
J. Clin. Endocrinol. Metab. 77, 1677-1682 (1993)
CYP11B1 human
GenEMBL D10169 D90428 (2085bp)
Kawamoto,T., Mitsuuchi,Y., Toda,K., Yokoyama,Y., Miyahara,K.,
Miura,S., Ohnishi,T., Ichikawa,Y., Nakao,K., Imura,H., Ulick,S.
and Shizuta,Y.
Role of steroid 11beta-hydroxylase and steroid 18-hydroxylase in the
biosynthesis of glucocorticoids and mineralocorticoids in humans.
Proc. Natl. Acad. Sci. USA 89, 1458-1462 (1992)
CYP11B1 human
PIR S29068 (30 amino acids)
Kawamoto, T., Mitsuuchi, Y., Toda, K., Miyahara, K.,
Yokoyama, Y., Nakao, K., Hosoda, K., Yamamoto, Y., Imura,
H. and Shizuta, Y.
Cloning of cDNA and genomic DNA for human cytochrome P-450
(11-beta).
FEBS Lett. 269, 345-349 (1990)
CYP11B1 Pan troglodytes (chimp)
UCSC genome browser 141679462-141681482 (-) strand
(N-term is in a seq gap), 3 aa diffs to human
GDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP DVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN
CYP11B1 Papio hamadryas ursinus (chacma baboon)
GenEMBL U52085(228bp)
Hampf,M., Swart,A. and Swart,P.
Expression of Papio ursinus steroid 11beta hydroxylase
unpublished (1996)
CYP11B1 Papio hamadryas ursinus (chacma baboon)
AY130288
MALRAKAEVCMAVPWLALQRARALGTRATRVPRTVLPFEAMPRR
PGNRWLRLLQIWREQGYEHLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQ
VDSLNPRRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPM
VDAVARDFSQALRKKVVQNARESVTLDIQPSIFHYTIEASNLALFGERLGLVGHSPSS
ASLSFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQ
ELALSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP
NVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVL
QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC
LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN
CYP11B1 Canis familiaris (dog)
XM_539192.2
73% to human 11B2, 72% to human 11B1
MPRLRPQDQKRSLVGRASLRPCASGSEAPIHLFRPPPPPRPPPP
PPALTPEPGFLASSRDSFSHDAIESPLQASGRDKRTVLTGDGGSIGMAFRAQARGWRA
GPWLALSRARALGTRAAPAPRAVLPFEAVPRCPGNKWMRVLQIWRQQGSESLHLEMHR
TFQELGPIFRYDVGGTHMVHVMLPEDVERLQRVESPQPWRPPLDPWLAYRQHRGHKCG
VFLLNGPEWRLNRLKLNPDVLSLQAVQKYIPMVDGVARDFSQALRARVLQNARGSLTL
DIRPSILYYTVEASSLALFGERLGLLGPSPSPASLHFLQALEAMLRSTAQLLYLPRGL
SRWTSARVWKEHFESWDYIVQYANEAIQRIYQELALGRPQHYSGIVGELLLRADLSPE
AVRANCIELTAGSVDTTAYPLWMTLFELARNPDVQHALRQESQGAQAGIAENPQTAVT
ELPLLRAALKETLRLYPVGISVDRQVGSDVVLQNYHIPAGTLVKVQLYSLGRNPSVFE
RPERYHPQRWLDGRGSGTRAPSLAFGFGVRQCLGRRLAETEMLLLLHHVLNNFLVETL
THEDVKMVYRFIMMPSTLPLLTFRAIH
Cyp11b1 mouse
PIR A41552 (500 amino acids)
Domalik, L.J., Chaplin, D.D., Kirkman, M.S., Wu, R.C., Liu,
W., Howard, T.A., Seldin, M.F., Parker, K.L.
Different isozymes of mouse 11beta-hydroxylase produce
mineralocorticoids and glucocorticoids.
Mol. Endocrinol. 5, 1853-1861 (1991)
Cyp11b1 mouse
PIR A32210 (42 amino acids)
Mouw, A.R., Rice, D.A., Meade, J.C., Chua, S.C., White, P.C.,
Schimmer, B.P. and Parker, K.L.
Structural and functional analysis of the promoter region of
the gene encoding mouse steroid 11beta-hydroxylase.
J. Biol. Chem. 264, 1305-1309 (1989)
Cyp11b1 mouse
GenEMBL J04451
80% to mouse 11B2 64% to human 11B1 and 11B2 80% to 11B1 rat
78% to 11B2 rat. sequence below is from Ensembl mouse version 3
15.75000001-76000000 mouse chr 15 add 75 million to get global location
306415 MALRVTTDVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQG 306356
306355 QENLHLEMHQVFRELGPIFR 306176 (?)
305773 HSVGKTQIVFVTLPEDVEKLYQVESTHPCRMPLESWIVHRELRGLGRGVFLL 305618 (?)
304234 NGPEWYFNRLQLNPNVLSPKAVQKFVPLVDGIARDFVDNLKKKMLESVHGSFSMDFQSSV 304175
304174 FNYTIE 304157 (?)
303918 ASHFVLFGERLGLIGRDLSPDSLKFLHTLHSMFKTTTQLLYLPRSLTRWTSTRVWKENLE 303859
303858 SWDFISEYG 303826 (?)
303446 TKCIKNVYRELAEGRPQSWSVTAELVAERTLSMDAIQANSMELIAGSTDT 303413 (0?)
301935 TSTPLVMTFFELARNPDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLR 301768
301535 LYPVGTFLERILSSDLVLQNYHVPAG 301458
301370 TVLNVNLYSMGRNPAVFPRPERYMPQRWLERKRSFKHLAFGFGVRQCLGRRLAEAEM 301314
301313 MLLLHH 301182 (?0)
300923 VLKSFHVETQEK 300888
300887 EDVRMAYRFVLMPSSSPLLTFRPVN 300705
CYP11B1 Mesocricetus auratus (hamster)
SwissProt P97720
1 MALRAKADVW LARPWQCLPR TRALGTTAAL APNTLRPFEA IPQYSRNRWL KMLQILREEG
61 QEGLHLEMHE AFRELGPIFR YSMGRTQVVY VMLPEVAEKV FQADSTQPSR TLLEPWVAHR
121 EHRGLSRGVF LLNGPEWRFN RLRINPHMLS PKAVQKFVPM VDMVARDFLE FLKKKVLANA
181 HGSLSMNFYS SMFNYTIEAS HFVLFGERLG LLGDDLNSGS LKFVNALNSI MKTTPQLMLL
241 PSGLTRWIST RVWKENFDSW DFVSEYVTKN VKNVYQEVQS GGPQSWSVIS QLVAEGALTM
301 DAILANSLEL TAGSVDTTSV PLVMTLFELA RNPDVQQAVR QESLAAEASV AANPQRAMSD
361 LPLLRAVLKE TLRLYPVAVF LERILSSDLV LQNYHVPAGT ILHMSLYSMG RNPAVFPRPE
421 HYLPQRWLER NGSFQHLTFG FGVRQCLGKR LAQVEMLLLL HHVLKSFRVE TQEREDVRMV
481 YRFVLAPSSS PLLTFRPVS
CYP11B1 rat
GenEMBL D10107 (1528bp) S58847
PIR B46040 (499 amino acids)
Matsukawa,N., Nonaka,Y., Higaki,J., Nagano,M., Mikami,H.,
Ogihara,T. and Okamoto,M.
Dahl's salt-resistant normotensive rat has mutations in
cytochrome P450 (11 beta), but the salt-sensitive hypertensive
rat does not.
J. Biol. Chem. 268, 9117-9121 (1993)
Note: only 1 amino acid difference with 11B1 at position 84
E (normal) changed to G (seen in 11B2 and 11B3)
D10107 has five differences with D11354
CYP11B1 rat
GenEMBL S58858 (330bp) PIR JX0251(499 amino acids)
Nomura,M., Morohashi, K.-i., Kirita, S., Nonaka, Y.,
Okamoto,M., Nawata,H. and Omura,T.
Three forms of rat CYP11B genes: 11 beta-hydroxylase gene,
aldosterone synthase gene, and a novel gene.
J. Biochem. 113, 144-152 (1993)
Note: Fig. 3 has 6 errors. 1,2) aldo-46 amino acids 2 and 3 are
incorrectly translated gctctc = AL not HS. 3) 11B3 codon at 559-561
incorrectly translated gac = D not N. 4,5,6) 11beta-62, 11B1
and 11B3 codon at 964-966 tcc = Ser not Pro.
CYP11B1 rat
GenEMBL S58849, D14086 to D14091 PIR A46039 (499 amino acids)
Mukai,K., Imai,M., Shimada,H. and Ishimura,Y.
Isolation and characterization of rat CYP11B genes involved
in late steps of mineralo- and glucocorticoid syntheses.
J. Biol. Chem. 268, 9130-9137 (1993)
CYP11B1 rat
GenEMBL S63899 (596bp)
Mukai,K., Imai,M., Shimada,H., Okada,Y., Ogishima,T. and
Ishimura,Y.
Structural differences in 5'-flanking regions of rat cytochrome
P-450aldo and P-450(11) beta genes
Biochem. Biophys. Res. Commun. 180, 1187-1193 (1991)
CYP11B1 rat
GenEMBL D11354 (1528bp) PIR A46040 (499 amino acids)
Matsukawa,N., Nonaka,Y., Higaki,J., Nagano,M., Mikami,H.,
Ogihara,T. and Okamoto,M.
Dahl's salt-resistant normotensive rat has mutations in
cytochrome P450 (11 beta), but the salt-sensitive hypertensive
rat does not.
J. Biol. Chem. 268, 9117-9121 (1993)
Note: This sequence is the wild type DS rat sequence. The mutant
DR rat has five amino acids differences accession number D10107
CYP11B1 Cavia porcellus (guinea pig)
GenEMBL Z69785(2028bp)
Bulow,H.E., Mobius,K., Bahr,V. and Bernhardt,R.
Molecular cloning and functional expression of the cytochrome P450
11B-hydroxylase of the guinea pig.
Biochem. Biophys. Res. Commun. 221, 304-312 (1996)
CYP11B1 bovine
PIR JX0151 (503 amino acids)
Kirita, S., Hashimoto, T., Kitajima, M., Honda, S.,
Morohashi, K. and Omura, T.
Structural analysis of multiple bovine P-450(11beta) genes
and their promoter activities.
J. Biochem. 108, 1030-1041 (1990)
CYP11B1 Bos taurus (cow)
See cattle page for details
MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRC
PGNKWMRMLQIWKEQSSENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQ
ADSHHPQRMILEPWLAYRQARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPL
VDGVARDFSQTLKARVLQNARGSLTLHIAPSVFRYTIEASTLVLYGERLGLLTQQPNP
DSLNFIHALEAMLKSTVQLMFVPRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQ
ELALGHPWHYSGIVAELLMRADMTLDTIKANTIDLTAGSVDTTAFPLLMTLFELARNP
EVQQAVRQESLVAEARISENPQRAITELPLLRAALKETLRLYPVGITLEREVSSDLVL
QNYHIPAGTLVKVLLYSLGRNPAVFARPESYHPQRWLDRQGSGSRFPHLAFGFGVRQC
LGRRVAEVEMLLLLHHVLKNFLVETLEQEDIKMVYRFILMPSTLPLFTFRAIQ
CYP11B1 pig
GenEMBL D38590(1671bp)
Sun,T., Zhao,Y., Nonaka,Y. and Okamoto,M.
Cloning and expression of cytochrome P450(11 beta) of porcine
adrenal cortex.
J. Steroid Biochem. Mol. Biol. 52, 227-232 (1995)
MAIWAKAEAWLAGPWLALNRARTLGTRAVLAPKGVLPFEAIPQF
PGKKWMRVLQLWREQGFENNHLEMHQTFQELGPIFRFDVGGRNMVLVMLPEDVERCQK
VEGLHPQRDVPGPWLAYRHLRGHKCGVFLLNGPTWRLDRLQLNPGVLSLQAMQKFTPL
VDGVARDFSQALRARVMQNARGSLTLDIKPSIFRYTIEASNLVLFGERLGLLAHQPNP
ESLDFIHALEVMFKSTVQLMFMPRSLSRWTSTGTWKEHFEAWDCIFQYANKAIQRLYQ
ELTLGHPWHYSGVVAELLTHANMTVDAIKANSIDLTAGSVDTTAYPLLMTLFELARNP
EVQQALRQESLAAAARISENPQKAITELPLLRAALKETLRLYPVGIFLDRCVTSDLVL
QNYHIPAGTLVKVLLYSLGRNPAVFARPERYHPQRWLDNQGSGTRFPHLAFGFGMRQC
LGRRLAQVEMLLLLHHVLKNFLVETLVQEDIKMIYRFIMTPSTLPLLTFRAIS
CYP11B1 sheep
GenEMBL L34337 (1639bp)
Boon,W.C., Roche,P.J., Hammond,V.E., Jeyaseelan,K.,
Crawford,R.J. and Coghlan,J.P.
Cloning and expression analysis of a cytochrome P450-11-beta
cDNA in sheep.
unpublished (1994)
CYP11B1 Ovis aries (sheep)
GenEMBL L28716 (2300bp)
Anwar,A., Jeyaseelan,K. and Coghlan,J.P.
Molecular cloning and characterization of the ovine CYP11B1
promoter.
Biochem. Mol. Biol. Int. 33, 1169-1178 (1994)
CYP11B1 Ovis ammon (sheep)
GenEMBL L47569(9027bp)
Anwar,A., Jeyaseelan,K. and Coghlan,J.P.
Characterization of an ovine 11-beta hydroxylase (cyp11b) gene.
unpublished (1995)
CYP11B1 Xenopus tropicalis
54949_prot X. tropicalis predicted protein from UCSC browser
scaffold_1888:38981-41244
trace archive 483095886 413360250 242989364 mate = 242988788
584719101 584719005 234592190
50% to 11B2 human 49% to 11B1
scaffold_8238:179-3044 UCSC browser
387238891 419638572 mate = 419631756
93% to X. laevis CYP11B1, 76% to CYP11B2 Rana catesbeiana D10984
NOTE: last exon corrected 8/29/2012
MMAALVCGGTCSWDTVRGLRTKSTHFSTVQLAQDSQSLTSAKAQS
LPFKSIPCTGRNAWANLARYWKNNSFQQLHLVMEGHFQNLGPIYR (2)
ETLGTHSSVNIIHPQDVARLFQSEGVFPRRMGIEAWAAHRDLRNHKCGVFLL (2)
NGEDWRSDRLILNKEVLSLTGVKKFLPFLDEVANDFVSFLMRRINKNTRGTLTVDLYADLFRFTME (1)
ASGYVLYGQRLGLLEEHPNEDSLRFIRAVETMIKTTLPLVYLPHQLLRLTDSALWTQHMEAWDVIFQQ (1)
ADRCIQNIYQEFCLGQERGYSGIMAELLLQGELPLDSITANVTELMAGGVDT (0)
TAMPLLFTLFELARNPSVQQELRAEIKRAEGQCPKDMNQLLNSMPLLKGAIKETLR (2)
LYPVGITVQRYPMKDIVLQNYHIPAG (0)
TLVQVGLYPMGRSSELFQNPLRYDPTRWMRRDETNFKALAFGFGSRQCIGRRIAETEMMLFLMH (0)
MIKNFQINTVCKDDIKTVFRFILMPEKPPLLTFRPV*
CYP11B1 Xenopus laevis (African clawed frog)
SwissProt Q71ME8 extended with ESTs CF522102.1 CB559154.1
AF449175.1
Missing 143 aa at C-term
MLEIRAIGHLRSCVVGLGSWESVRCLRTEATRFSTVQLAHDSQSL
APAKAQTLPFKDIPCTGRNPWTNLARYWKNNSFQHLHLVMEDHFQNLGPIYR
ENLGTHSSVNIIHPHDVARLFQSEGIFPRRMGIGVWAAHRDLRNHKCGVFL LNGEEWRSDWLILNKEVLSLAGVKKFLPFLDEVANDFVSFLMRRINKNTRGTLTVDLYA DLFRFTMEASGYVLYGLRLGLLEEHPNEDSLRFIRAVETMIKTTLPLLYLPHQLLRLMD SSLWIQHMEAWDIIFQQTDRCIQNIYQEFCLGQERGYSGIMAELLLQGELPLDSIKANV TELMAGGVDT
TAMPLLFTLFELARNPITS
CYP11B1X Danio rerio (zebrafish)
See zebrafish pages for seq
Name revised to CYP11C1
CYP11B1X Takifugu rubripes (fugu, Japanese pufferfish)
Scaffold_9267 Length = 9352
cyp11 like N-TERMINAL exons 1 and 2
Name revised to CYP11C1
8573 MWLPAGAGVRARSARGFRTAAGAVVDGKVGACKGAEVPESKKGVDGQVRSFEEIPHTG 8746
8747 RNSWVNLLRFWREDRFRHLHKHMERNFNSLGPIYR (2)
EPVGAPNSVNIMLPSDISELSRSEGLHPRRMTLQPWATHRETRKHGKGGFHK (2)
254 NGEEWRADRLLLNKEVMMSEAVRRFIPLLDEVAQDF
11719 ASCHVLYGERIGLFSSSPSLESQKFIWAVERMLATTPPLLYLPHRLLLHLGAPLWTQHASAWDHIFTH 11519 (1)
11438 AEERIQRGYQRLSHSQSRGPEGGGRYKGVLGQLMAKGQLSLELIKANITELMAGAVDT 11265 (0)
11178 TAVPLQFALFELGRNPEVQQRVRQQVQESWAQAGGDPQKALQEAPLLKGTIRETLR 11011 (2)
10465 LYPVGTTVQRYPVKDIVLQNYHIPAG (0)
TMVQACLYPLGRSAEVFEDPLRFDPGRWGKSREEGQRGGGTGFRSLAFGFGARQCVGRRIAENEMQLLLMH 10097 (0)
9896 ILLGFDLSVPSSEDIKTMCTLILMPETPPKITFTKL* 9786
CYP11B1X Tetraodon nigroviridis (Green puffer)
90% to CYP11B1 fugu
Name revised to CYP11C1
MYIPAGAGVRAGGARGLRLAAGAAVDGKGAEGSGSRKGGVDGQVRSFEEIPHTGRNSWV NLLRFWREDRFRQLHKHMERTFNALGPIYR (2)
EHVGTQSSVNIMLPSDISELFRSEGLHPRRMTLQPWATHRETRHHSKGVFLK (2)
NGEEWRADRLLLNKEVMMSEAVRRFLPLLDEVAKEFCQMLQTKVEKEGRGERGKRSLTIDPSPDLFRFALE (1)
ASCHVLYGERIGLFSSSPSLESQKFIWAVERMLATTPPLLYLPHRLLLHLGAPLWTQHASAWDHIFSH (1)
AEERIQRGYQRLSPSQSRDREGGGRYTGVLGQLMEKGQLSLELIKANITELMAGAVDT (0)
TAVPLQFALFELGRNPEVQQRVRQQVQASWARAGGDPQKALQEAPLLKGTIKETLR (2)
LYPVGTTVQRYPVKDIVLQNYHIPAG (0)
TMVQACLYPLGRSAEVFEDPRRFDPGRWGKSREEGQRGAGTGFRSLAFGFGARQCVGRRIAENEMQLLLMH (0)
ILLSFHLSVPSSEDIKTMCTLILQPETPPKITFSKL*
CYP11B1v1X Oncorhynchus mykiss (rainbow trout)
AF179894
Name revised to CYP11C1v1
MWSVSVSPSVFQGIQGMCVSVRQAVCVRIQRGMCVCPAGTVAGL
GVEGVTPAKGGPAGRGGGRGLRRFEEIPHTGSSGWLNLVKFWREDRFKLLHKHMERTF
NTLGPIYRERLGTQSTVNILLPSDISELFRSEGLHPRRMTLQPWATHRETRQHSKGVF
LKNGTEWRADRLLLNREVMMAPAVRRFLPLLDEVARDFCRLLATRVEQEGGKEERGHS
LTIDPSPDLFRFALEASCHVLYGERIGLFSTSPSQESQKFIFAVERMLATTPPLLYLP
PRLLWRLGAPLWTQHATAWDHIFSHAEKRIQRGVQRLHSTKAAGGGSGGAEGEFTGIL
GQLIDKGQLSLELIRANITELMAGGVDTTAVPLQFALYELGRNPAVQEQVRGQVRVAW
ARAGGDAHKALQGAPLLKGLVKETLRLYPVGITVQRYPVRDIIIQNYHIPAGTCVQAC
LYPLGRSRDVFQDPELFDPGRWGTQESGEGPGGGGGFRSLAFGFGARQCVGRRIAENE
MQLLLMHILLSFRLSVSSSEELSTKYTLILQPETPPRITFSTL
CYP11B1v2X Oncorhynchus mykiss (rainbow trout)
AF217273
Name revised to CYP11C1v2
MWSVSVSPSVFQGIQGMCVSVRQAACVRIQRGMCVCPAGTVAGL
GVEGVNPARGGPAERGGGRGLRRFEEIPHTGSSGWLNLVKFWREDRFKLLHKHMERTF
NTLGPIYRERLGTQSTVNILLPSDISELFRSEGLHPRRMTLQPWATHRETRQHSKGVF
LKNGAEWRADRLLLNREVMMAPAVRRFLPLLDEVARDFCCQLATRVEKDGGKEERGHS
LTIDPSPDLFRFALEASCHVLYGERIGLFSTSPSQESQKFIFAVERMLATTPPLLYLP
PRLLWRLGAPLWTQHATAWDIIFSHAEKRIQRGVQRLRSTQAAGGGSGGAEGEFTGIL
GQLMDKGQLSLELIRANITELMAGGVDTTAVPLQFALYELGRNPAVQEQVRVQVKAAW
ARAGGDAHKALQGAPLLKGLVKETLRLYPVGITVQRYPVRDIIIQNYHIPAGTCVQAC
LYPLGRSRDVFQDPERFDPGRWGTQESGEGPGGGGGFRSLAFGFGARQCVGRRIAENE
MQLLLMHILLSFRLSVSSSEELSTKYTLILQPETPPRITFSTL
CYP11B2 human
GenEMBL J05140 M32864 (1809bp) M32880 (3088bp) M32881 (1101bp)
Mornet,E., Dupont,J., Vitek,A. and White,P.C.
Characterization of two genes encoding human steroid 11-beta-
hydroxylase (P-450-11-beta).
J. Biol. Chem. 264, 20961-20967 (1989)
CYP11B2 human
GenEMBL D90429 D10170 (2114bp)
Kawamoto,T., Mitsuuchi,Y., Toda,K., Yokoyama,Y., Miyahara,K.,
Miura,S., Ohnishi,T., Ichikawa,Y., Nakao,K., Imura,H., Ulick,S.
and Shizuta,Y.
Role of steroid 11beta-hydroxylase and steroid 18-hydroxylase in the
biosynthesis of glucocorticoids and mineralocorticoids in humans.
Proc. Natl. Acad. Sci. USA 89, 1458-1462 (1992)
CYP11B2 human
GenEMBL D13752(6910bp)
Kawamoto,T., Mitsuuchi,Y., Ohnishi,T., Ichikawa,Y., Yokoyama,Y.,
Sumimoto,H., Toda,K., Miyahara,K., Kuribayashi,I., Nakao,K.,
Hosoda,K., Yamamoto,Y., Imura,H. and Shizuta,Y.
Cloning and expression of a cDNA for human cytochrome P-450aldo as
related to primary aldosteronism.
Biochem. Biophys. Res. Commun. 173 (1), 309-316 (1990)
CYP11B2 human
GenEMBL S77398 S77401 S77403 S77406 S77409 (genomic sequences)
Shizuta,Y., Kawamoto,T., Mitsuuchi,Y., Miyahara,K., Rosler,A.,
Ulick,S. and Imura,H.
Inborn errors of aldosterone biosynthesis in humans.
Steroids 60 (1), 15-21 (1995)
CYP11B2 Pan troglodytes (chimpanzee)
XM_519994.3
96% to human
MALRAKAEVCVAAPWLSLQRARALGTRAPRAPRTVLPFEAMPQH PGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQ VDSLHPRRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPM VDAVARDFSQALRKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSS ASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQ ELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNP DVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVL QNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQC LGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSTFPLLTFRAIN
CYP11B2 Bos taurus (cow)
See cattle page for details
MALWAKARVRMAGPWLSLHEARLLGTRGAAAPKAVLPFEAMPRCPGNKWMRMLQIWKE
QSSENMHLDMHQTFQELGPIFRYDVGGRHMVFVMLPEDVERLQQADSHHPQRMILEPWLA
YRQARGHKCGVFLLNGPQWRLDRLRLNPDVLSLPALQKYTPLVDGVARDFSQTLKARVLQ
NARGSLTLDIAPSVFRYTIEASTLVLYGERLGLLTQQPNPDSLNFIHALEAMLKSTVQLM
FVPRRLSRWMSTNMWREHFEAWDYIFQYANRAIQRIYQELALGHPWHYSGIVAELLMRAD
MTLDTIKANTIDLTAGSVDTTAFPLLMTLFELARNPEVQQAVRQESLVAEARISENPQRA
ITELPLLRAALKETLRLYPVGITLEREVSSDLVLQNYHIPAGTLVKVLLYSLGRNPAVFA
RPESYHPQRWLDRQGSGSRFPHLAFGFGVRQCLGRRVAEVEMLLLLHHVLKNFLVETLEQ
EDIKMVYRFILMPSTLPLFTFRAIQ*
CYP11B2 Sus scrofa (pig)
ESTs CV872108.1, BI341717.1
93% to 11B1 pig
MAIWAKAEAWLAGPWLALHRARTLGTRAALAPKAVLPFEAIPQCPGNKWMRVLQLWREQG
FENIHLDMHQTFQELGPIFRFDVGGRHMVLVMLPEDVERLQKVEGLHPQRMFLEPWLAYR
QLRGHKCGVFLLNGPTWRLDRLQLNPGVLSLQAMQKFTPLVDGVARDFSQALRARVMQNA
RGSLTLDIKPSIFRYTIEASNLVLFGERLGLLAHQPNPES
CYP11B2 Canis familiaris (dog)
XM_846295.1 in a seq gap in the genome
MAFRAQARGWRAGPWLAL
SRAPTLGTRAAPAPRAVLPFEAVPRCPGNKWMRVLQIWRQQGSESLHLEMHRTFQELG
PIFR
YDVGGTHMVHVMLPEGMERLQRGESPQPDTSPW
CYP11B2 rat
GenEMBL S58859 (353bp) PIR JX0252 (500 amino acids)
Nomura,M., Morohashi, K.-i., Kirita, S., Nonaka, Y.,
Okamoto,M., Nawata,H. and Omura,T.
Three forms of rat CYP11B genes: 11 beta-hydroxylase gene,
aldosterone synthase gene, and a novel gene.
J. Biochem. 113, 144-152 (1993)
CYP11B2 rat
GenEMBL S58850 D14092 to D14097
PIR B46039 (500 amino acids)
Mukai,K., Imai,M., Shimada,H. and Ishimura,Y.
Isolation and characterization of rat CYP11B genes involved
in late steps of mineralo- and glucocorticoid syntheses.
J. Biol. Chem. 268, 9130-9137 (1993)
CYP11B2 rat
GenEMBL S63898 (594bp)
Mukai,K., Imai,M., Shimada,H., Okada,Y., Ogishima,T. and Ishimura,Y.
Structural differences in 5'-flanking regions of rat cytochrome
P-450aldo and P-450(11) beta genes.
Biochem. Biophys. Res. Commun. 180, 1187-1193 (1991)
CYP11B2 rat
GenEMBL S64136 (3001bp) PIR JN0615 (506 amino acids)
GenEMBL U14908 (3000bp)
Zhou,M. and Gomez-Sanchez,C.E.
Cloning and expression of a rat cytochrome P-450 11
beta-hydroxylase/aldosterone synthase (CYP11B2) cDNA variant.
Biochem. Biophys. Res. Commun. 194, 112-117 (1993)
Erratum: Biochem. Biophys. Res. Commun. 196, 1018 (1993)
CYP11B2 rat
PIR A34281 (20 amino acids) Swiss P30099 (510 amino acids)
Ogishima, T., Mitani, F., Ishimura, Y.
Isolation of aldosterone synthase cytochrome P-450 from zona
glomerulosa mitochondria of rat adrenal cortex.
J. Biol. Chem. 264, 10935-10938 (1989)
Note: sequence is from N-terminal after signal sequence
CYP11B2 rat
Swiss P30099 (510 amino acids) GenEMBL D00567 (2824bp)
Swiss P30100 (500 amino acids) GenEMBL D00568 (2705bp)
Matsukawa,N., Nonaka,Y., Ying,Z., Higaki,J., Ogihara,T. and
Okamoto,M.
Molecular cloning and expression of cDNAs encoding rat aldosterone
synthase: variants of cytochrome P-450 11beta
Biochem. Biophys. Res. Commun. 169, 245-252 (1990)
CYP11B2 hamster
GenEMBL S73810 (1503bp)
LeHoux,J.G., Mason,J.I., Bernard,H., Ducharme,L., LeHoux,J.,
Veronneau,S. and Lefebvre,A.
The presence of two cytochrome P450 aldosterone synthase mRNAs in
the hamster adrenal.
J. Steroid Biochem. Mol. Biol. 49, 131-137 (1994)
CYP11B2 Cavia porcellus (domestic guinea pig)
GenEMBL AF018569
Buelow,H.E. and Bernhardt,R.
Molecular Cloning and Functional Expression of the Guinea Pig
Aldosterone Synthase.
Unpublished
CYP11B2 Rana catesbeiana (bullfrog)
GenEMBL D10984 (1919bp)
Nonaka,Y., Takemori,H., Halder,S.K., Sun,T., Ohta,M., Hatano,O.,
Takakusa,A. and Okamoto,M.
Frog Cytochrome P-450 (11 beta, aldo), a single enzyme involved in
the final steps
of glucocorticoid and mineralocorticoid biosynthesis.
Eur. J. Biochem. 229, 249-256 (1995)
MLEKTAARQIGSCLMRCRTLDTTSPLWTGFSRLSTAPLIHEARE
DGSLASQTLPYEAIPTTGRSAWFNLFQFWRKNSFQHMHLAMEENFQNLGPIYREKLGT
HNSVNIMLPQDVARLFQSEGIFPRRMTMEAWSKHRELRNHKQGVFLLNGEAWRSDRII
LNKEVLSLAGVKKFLPFLDEAAADFVTFMKKRMSKNTRGSLTVDLYADLFRFTLEASS
YVLYGQRLGLLEEHPNADTLRFISAVETVLKTTLPLLYYPHQILQLFQTRLWNEHMHA
WDVIFEQADRCIQNIYQEYCLGQERGYSGIMAELLLQAELPLDSIKANITELMAGGVD
TTAMPLLFTLFELARNPSVQRELREEIRKAEAQNPNDLNQLLNSLPLLKGAIKETLRL
YPVGITVQRHLIKDIVLHNYHIPAGTLVQVGLYPMGRSPLLFQDALRYDPARWLKRED
TNFKALAFGFGSRQCIGRRIAETEITLFLMHMLKNFQIDTVSKDDIKTVFGFILMPEK
PPLLTFRPI
Cyp11b2 mouse
GenEMBL S85260 (2804bp)
Domalik,L.J., Chaplin,D.D., Kirkman,M.S., Wu,R.C., Liu,W.W.,
Howard,T.A., Seldin,M.F. and Parker,K.L.
Different isozymes of mouse 11 beta-hydroxylase produce
mineralocorticoids and glucocorticoids.
Mol. Endocrinol. 5, 1853-1861 (1991)
Cyp11b2 mouse
genEMBL S85260
68% to human 11B2 67% to human 11b1 94% to 11B2 rat 81% to 11B1 rat
sequence below is from Ensembl mouse version 3
15.75000001-76000000 mouse chr 15 add 75million to get global location
321034 MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLQPFEAIPQYSRNKWLKMIQILREQG 320975
320974 QENLHLEMHQVFRELGPIFR 320795 (?)
320391 HSVGKTQIVSVMLPEDAEKLHQVESMLPRRMHLEPWVAHRELRGLRRGVFLL 320238 (?)
318803 NGPEWRLNRLRLNRNVLSPKAVQKFVPMVDMVARDFLETLKEKVLQNARGSLTM 318762
318761 DVQQSLFNYTIE 318606 (?)
318477 ASNFALFGERLGLLGHDLSPGSLKFIHALHSMFKSTS 318487
318486 QLLFLPKSLTRWTSTRVWKEHFDAWDVISEYG (?) 318391
318000 NRCIWKVHQELRLGSSQTYSGIVAELISQGSLPLDAIKA 318004
318003 NSMELTAGSVDT 317848 (?)
316981 TAIPLVMTLFELARNPDVQKALRQESLAAEASIAANPQKAMSDLPLLRAALKETLR 316814 (?)
316581 LYPVGGFLERILSSDLVLQNYHVPAG 316504 (0?)
316416 TLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFG 316396
316395 VRQCLGRRLAEVEMMLLLHH 316228 (0?)
315961 ILKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPVS 315851
CYP11B3 rat
PIR JX0253 (498 amino acids)
Nomura,M., Morohashi, K.-i., Kirita, S., Nonaka, Y.,
Okamoto,M., Nawata,H. and Omura,T.
Three forms of rat CYP11B genes: 11 beta-hydroxylase gene,
aldosterone synthase gene, and a novel gene.
J. Biochem. 113, 144-152 (1993)
CYP11B3 rat
GenEMBL U14907 (1497bp)
Zhou,M., Gomez-Sanchez,E.P., Foecking,M. and Gomez-Sanchez,C.E.
Cloning of the cytochrome P-450 CYP11B3 complementary DNA in the
rat.
unpublished
CYP11B3 rat
GenEMBL S59144 D14098 to D14103
Mukai,K., Imai,M., Shimada,H. and Ishimura,Y.
Isolation and characterization of rat CYP11B genes involved
in late steps of mineralo- and glucocorticoid syntheses.
J. Biol. Chem. 268, 9130-9137 (1993)
Note: only one amino acid difference with Nomura's 11B3
CYP11B3 rat
GenEMBL U17082(1497bp)
Mellon,S.H., Bair,S.R. and Monis,H.
P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed
in a tissue-specific, developmentally, and hormonally regulated
fashion in the rodent adrenal and encodes a protein with both
11-hydroxylase and 18-hydroxylase activities.
J. Biol. Chem. 270, 1643-1649 (1995)
Note Genbank has a seq from rat named CYP11B4 D14108
This is part of the CYP11B8P pseudogene (see below)
CYP11B4 cattle
Kirita et al. 1990 J. Biochem (Tokyo) 108, 1030-1041.
Listed in 1996 nomenclature update
As having the same coding region sequence
But different flanking regions
CB11beta-20
CYP11B5P cattle
GenEMBL JU0316
Kirita et al. 1990 J. Biochem (Tokyo) 108, 1030-1041.
CB11beta-1 pseudogene
CYP11B6P cattle
GenEMBL JU0317
Kirita et al. 1990 J. Biochem (Tokyo) 108, 1030-1041.
CB11beta-3 pseudogene
CYP11B7P cattle
GenEMBL JU0318, D00458, D00459
Hashimoto et al. 1989 J. Biochem (Tokyo) 105, 676-679.
LambdaB11beta(15-1) and (15-2)
Kirita et al. 1990 J. Biochem (Tokyo) 108, 1030-1041.
CB11beta-21 pseudogene
CYP11B8P rat pseudogene
GenEMBL D14104 to D14108
Mukai,K., Imai,M., Shimada,H. and Ishimura,Y.
Isolation and characterization of rat CYP11B genes involved
in late steps of mineralo- and glucocorticoid syntheses.
J. Biol. Chem. 268, 9130-9137 (1993)
Note: authors call this sequence 11B4
CYP11C1 Danio rerio (zebrafish)
See zebrafish pages for seq
Name revised to CYP11C1
CYP11C1 Takifugu rubripes (fugu, Japanese pufferfish)
Scaffold_9267 Length = 9352
cyp11 like N-TERMINAL exons 1 and 2
Name revised from CYP11B1
8573 MWLPAGAGVRARSARGFRTAAGAVVDGKVGACKGAEVPESKKGVDGQVRSFEEIPHTG 8746
8747 RNSWVNLLRFWREDRFRHLHKHMERNFNSLGPIYR (2)
EPVGAPNSVNIMLPSDISELSRSEGLHPRRMTLQPWATHRETRKHGKGGFHK (2?)
254 NGEEWRADRLLLNKEVMMSEAVRRFIPLLDEVAQDF
11719 ASCHVLYGERIGLFSSSPSLESQKFIWAVERMLATTPPLLYLPHRLLLHLGAPLWTQHASAWDHIFTH 11519 (1)
11438 AEERIQRGYQRLSHSQSRGPEGGGRYKGVLGQLMAKGQLSLELIKANITELMAGAVDT 11265 (0)
11178 TAVPLQFALFELGRNPEVQQRVRQQVQESWAQAGGDPQKALQEAPLLKGTIRETLR 11011 (2)
10465 LYPVGTTVQRYPVKDIVLQNYHIPAG (0)
TMVQACLYPLGRSAEVFEDPLRFDPGRWGKSREEGQRGGGTGFRSLAFGFGARQCVGRRIAENEMQLLLMH 10097 (0)
9896 ILLGFDLSVPSSEDIKTMCTLILMPETPPKITFTKL* 9786
CYP11C1 Tetraodon nigroviridis (Green puffer)
90% to CYP11B1 fugu
Name revised from CYP11B1
MYIPAGAGVRAGGARGLRLAAGAAVDGKGAEGSGSRKGGVDGQVRSFEEIPHTGRNSWV NLLRFWREDRFRQLHKHMERTFNALGPIYR (2)
EHVGTQSSVNIMLPSDISELFRSEGLHPRRMTLQPWATHRETRHHSKGVFLK (2)
NGEEWRADRLLLNKEVMMSEAVRRFLPLLDEVAKEFCQMLQTKVEKEGRGERGKRSLTIDPSPDLFRFALE (1)
ASCHVLYGERIGLFSSSPSLESQKFIWAVERMLATTPPLLYLPHRLLLHLGAPLWTQHASAWDHIFSH (1)
AEERIQRGYQRLSPSQSRDREGGGRYTGVLGQLMEKGQLSLELIKANITELMAGAVDT (0)
TAVPLQFALFELGRNPEVQQRVRQQVQASWARAGGDPQKALQEAPLLKGTIKETLR (2)
LYPVGTTVQRYPVKDIVLQNYHIPAG (0)
TMVQACLYPLGRSAEVFEDPRRFDPGRWGKSREEGQRGAGTGFRSLAFGFGARQCVGRRIAENEMQLLLMH (0)
ILLSFHLSVPSSEDIKTMCTLILQPETPPKITFSKL*
CYP11C1v1 Oncorhynchus mykiss (rainbow trout)
AF179894
Name revised from CYP11B1v1
MWSVSVSPSVFQGIQGMCVSVRQAVCVRIQRGMCVCPAGTVAGL
GVEGVTPAKGGPAGRGGGRGLRRFEEIPHTGSSGWLNLVKFWREDRFKLLHKHMERTF
NTLGPIYRERLGTQSTVNILLPSDISELFRSEGLHPRRMTLQPWATHRETRQHSKGVF
LKNGTEWRADRLLLNREVMMAPAVRRFLPLLDEVARDFCRLLATRVEQEGGKEERGHS
LTIDPSPDLFRFALEASCHVLYGERIGLFSTSPSQESQKFIFAVERMLATTPPLLYLP
PRLLWRLGAPLWTQHATAWDHIFSHAEKRIQRGVQRLHSTKAAGGGSGGAEGEFTGIL
GQLIDKGQLSLELIRANITELMAGGVDTTAVPLQFALYELGRNPAVQEQVRGQVRVAW
ARAGGDAHKALQGAPLLKGLVKETLRLYPVGITVQRYPVRDIIIQNYHIPAGTCVQAC
LYPLGRSRDVFQDPELFDPGRWGTQESGEGPGGGGGFRSLAFGFGARQCVGRRIAENE
MQLLLMHILLSFRLSVSSSEELSTKYTLILQPETPPRITFSTL
CYP11C1v2 Oncorhynchus mykiss (rainbow trout)
AF217273
Name revised from CYP11B1v2
MWSVSVSPSVFQGIQGMCVSVRQAACVRIQRGMCVCPAGTVAGL
GVEGVNPARGGPAERGGGRGLRRFEEIPHTGSSGWLNLVKFWREDRFKLLHKHMERTF
NTLGPIYRERLGTQSTVNILLPSDISELFRSEGLHPRRMTLQPWATHRETRQHSKGVF
LKNGAEWRADRLLLNREVMMAPAVRRFLPLLDEVARDFCCQLATRVEKDGGKEERGHS
LTIDPSPDLFRFALEASCHVLYGERIGLFSTSPSQESQKFIFAVERMLATTPPLLYLP
PRLLWRLGAPLWTQHATAWDIIFSHAEKRIQRGVQRLRSTQAAGGGSGGAEGEFTGIL
GQLMDKGQLSLELIRANITELMAGGVDTTAVPLQFALYELGRNPAVQEQVRVQVKAAW
ARAGGDAHKALQGAPLLKGLVKETLRLYPVGITVQRYPVRDIIIQNYHIPAGTCVQAC
LYPLGRSRDVFQDPERFDPGRWGTQESGEGPGGGGGFRSLAFGFGARQCVGRRIAENE
MQLLLMHILLSFRLSVSSSEELSTKYTLILQPETPPRITFSTL
12A Subfamily
CYP12A1 Musca domestica (housefly)
GenEMBL U86618
Rene Feyereisen
MIKYKQYSRAIVALRQRGAQQYSTNVTNASQPDVKATTTTTISP
EWQEAKPFEEMPSMNSWPIIKNMLPWGKYGKMEPTQFLMALRDDMGPIVRTAAFMGRP
PTVITHNPHDFEMVFRNEGIWPIRPGGDAQMYHRTVLREDFFQGVTGLVSVNGEKWGN
FRSTVNPVLMQPKNVRLYLNKMAQVNDEFMARIRQIRDPETLEVPASFQEEMNRWTLE
SVSVVALDKQLGLITTNRDNPDLKKLIGLLNDFFELGQKIEFGLPFWKYIKTPTFKLF
MKTLDGLLEIGNKYVNEAIDRLEAERQSGVPEKPENEKSVLEKLIKIDRKIATVMAID
MILAGVDTTSTTFTALLLCLAKNPEKQEKLREEIRQILPRKDSQFEPSSLNHIPYTRA
CIKEALRMYPLTLGNARILANDTVLSGYRVPKGTLVSMISTGLLQDDNHYTKAKEYLP
ERWMRPTKEETEDSATCPHALKASSPFIYLPFGFGPRSCVGRRIVEMELELGIARLVR
NFRIEFNYPTENAFKFKLINVPNIPLKFKFTDVEN
CYP12A2 Musca domestica (housefly)
GenEMBL U94698
Rene Feyereisen
CYP12A3 Musca domestica (housefly)
GenEMBL U94699
Rene Feyereisen
cyp12a4 Drosophila melanogaster
GenEMBL AC006091 85973-87865 also AC015190 AC008141
chromosome 3 clone BACR48G05 (D475)
MLKVRSALSLIQSQKATLSLATQKHTEYFKILLYIYINKLYYQRWQTNVATAEAREDSEW
LQAKPFEQIPRLNMWALSMKMSMPGGKYKNMELMEMFEAMRQDYGDIFFMPGIMGNPPFL
STHNPQDFEVVFRNEGVWPNRPGNYTLLYHREEYRKDFYQGVMGVIPTQGKPWGDFRTVV
NPVLMQPKNVRLYYKKMSQVNQEFVQRILELRDPDTLEAPDDFIDTINRWTLESVSVVAL
DKQLGLLKNSNKESEALKLFHYLDEFFIVSIDLEMKPSPWRYIKTPKLKRLMRALDGIQE
VTLAYVDEAIERLDKEAKEGVVRPENEQSVLEKLLKVDRKVATVMAMDMLMAGVDTTSST
FTALLLCLAKNPEKQARLREEVMKVLPNKNPEFTEASMKNVPYLRACIKESQRLHPLIVG
NARVLARDAVLSGYRVPAGTYVNIVPLNALTRDEYFPQASEFLPERWLRSPKDSESKCPA
NELKSTNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRNFNVEFNYPTENAFRSALIN
LPNIPLKFKFIDLPN
Cyp12a4 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
cyp12a5 Drosophila melanogaster
GenEMBL AC006091 83449-85296 also AC015190 AC008141
chromosome 3 clone BACR48G05 (D475)
76% identical to other AC006091 SEQ. 58% TO 12A1, 12A2
MLKGRIALNILQSQKPIVFSASQQ*RWQTNVPTAEIRNDPEWLQAKPFEE
IPKANILSLFAKSALPGGKYKNLEMMEMIDALRQDYGNIIFLPGMMGRDG
LVMTHNPKDFEVVFRNEGVWPFRPGSDILRYHRTVYRKDFFDGVQGIIPS
QGKSWGDFRSIVNPVLMQPKNVRLYFKKMSQVNQEFIKEIRDASTQEVPG
NFLETINRWTLESVSVVALDKQLGLLRESGKNSEATKLFKYLDEFFLHSA
DLEMKPSLWRYFKTPLLKKMLRTMDSVQEVTLKYVDEAIERLEKEAKEGV
VRPEHEQSVLEKLLKVDKKVATVMAMDMLMAGVDTTSSTFTALLLCLAKN
PEKQARLREEVMKVLPNKDSEFTEASMKNVPYLRACIKESQRVYPLVIGN
ARGLTRDSVISGYRVPAGTIVSMIPINSLYSEEYFPKPTEFLPERWLRNA
SDSAGKCPANDLKTKNPFVFLPFGFGPRMCVGKRIVEMELELGTARLIRN
FNVEFNHSTKNAFRSALINLPNIPLKFKFKFTDVPN*
Cyp12a5 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP12A6 Drosophila wassermani
no accession number
Tina Yee and Phil Danielson
59% to 12A2 56% to 12A1
N-terminal does not match known P450 sequences may be in error
CYP12A7 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
revised to full length June 27, 2005
Clone name Lc_CYP12A2
59% to 12A5
CYP12A8 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP12A1
60% to 12A5 67% to 12A7 (365 aa)
CYP12A9 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Revised seq Dec 12, 2007
Old Clone name Lc_CYP12A3
New clone name Luce0104J9 (408 aa)
74% identical to Musca Domestica CYP12A2
only 1 aa diff to earlier shorter version
CYP12A10 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP12A4
57% to 12A4 65% to 129A9 (126 aa)
CYP12A11 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0102F03
62% identical to CYP12A2 and 57% identical to Dm CYP12a5,
63% to 12A7, 72% to 12A8 partial seq, 64% to 12A9 partial,
67% to 12A10 partial seq.
12B Subfamily
CYP12B1 Drosophila acanthoptera
no accession number
Phil Danielson
Ac40
submitted to nomenclature committee
Cyp12b2 Drosophila melanogaster
GenEMBL AC018326 7227-9141 also AC004345 AC004657
77% identical to 12b1
Cyp12b2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp12c1 Drosophila melanogaster
GenEMBL AC009385 comp(57935-59646) also AC012807
Cyp12c1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP12C2 Bactrocera orientalis (oriental fruit fly)
No accession number
Yong Huang
Submitted to nomenclature committee March 16, 2012
54% to Cyp12c1 Drosophila melanogaster
Cyp12d1 Drosophila melanogaster
GenEMBL AC008187 comp(84371-86114)
Cyp12d1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP12D2 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Lce0054K20
53% identity to Dm CYP12d1
probable ortholog of Cyp12d1
Cyp12e1 Drosophila melanogaster
GenEMBL AC018294 2070-3932
Cyp12e1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP12F1 Anopheles gambiae (malaria vector)
No accession number
Submitted by Rene Feyereisen July 5, 2002
Low 40% range with other CYP12s 60% to 12F2
CYP12F1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPl3r4
CYP12F2 Anopheles gambiae (malaria vector)
No accession number
Submitted by Rene Feyereisen July 5, 2002
Low 40% range with other CYP12s 60% to 12F1
CYP12F2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPl3r3
CYP12F3 Anopheles gambiae (malaria vector)
No accession number
Submitted by Rene Feyereisen July 5, 2002
Low 40% range with other CYP12s 60% to 12F2
CYP12F3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPl3r2
CYP12F4 Anopheles gambiae (malaria vector)
No accession number
Submitted by Rene Feyereisen July 5, 2002
Low 40% range with other CYP12s 55% to 12F2
CYP12F4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPl3r1
CYP12F5 Aedes aegypti (yellow fever mosquito)
CYP12F6 Aedes aegypti (yellow fever mosquito)
CYP12F7 Aedes aegypti (yellow fever mosquito)
CYP12F8 Aedes aegypti (yellow fever mosquito)
CYP12F9 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 15
68% to 12F7 Aedes, 60% to 12F2
CYP12F9 Culex pipiens
CYP12F10 Culex pipiens
CYP12F11 Culex pipiens
CYP12F12 Culex pipiens
CYP12F13 Culex pipiens
CYP12F14 Culex pipiens
CYP12G1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP12C
51% to 12C1 (310 aa)
CYP12H1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966937, DT790363.1 EST
37% to 12c1, 38% to 12A4 mito clan, 42% to 12F2
MSTGSENVISQKKLDHYKNLNALENSDVMPEGWDKAKPFESLPGPKPIPFFGN
IWRFLVPKIGDFYGIDFLDLHKIFYEQYGDISILKGMINDPIVVIFNPKDYETLFRNEGIWPIRKGLQSF
NEYRKSRKDIFVNAGLLLEEGENWFKIRSVVNPILMQPRNISQYTDKMNSVADELVNNITNLLEESENGE
MPENFHNELYKWSLESVGLVTLDTHLGCLKNDLDEDSEPQKLIRSTLEMFKLMHKLDVLPSFHNYVSTPS
WRKFVQVMDFIVETNMKYVNQVLDKLEKGETTSTEIPSVLEKLLKVDRNIAVTMSIDMMIAGIDTTGRIL
GAALYFLGKNHEAQEKLRSEAISLLQTKDQAVTSEVLKKAPYLKAVIKETTRLAPIGIGNLRTTVKNLVL
GGYQIPKGTDVVTSNLVLCTNDEYFSRAKEFIPERWLSTTSGELSKKNTNPFIFAPFGYGPRSCVGKRLA
SLELEVALLKIIRNFELDWPHEDMVFKTKMLYGMTEPLKIHVRSV
CYP12H2 part 1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 11
47% to CYP12H1 Tribolium castaneum
N-terminal
CYP12H2 part 2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 27
48% to CYP12H1 Tribolium castaneum
C-helix to middle
CYP12H3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP12H3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
100% to CYP12H3 Leptinotarsa
partial seq.
CYP12J1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P12F5113
59 amino acids from heme to end
42% to 12A4, 57% to CYP12H1 XP_966937
5 aa diffs to CYP12J2
58% to XM_961844.1 PREDICTED: Tribolium castaneum
37% to 12c1, 38% to 12A4, 42% to 12f2
CYP12J2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P12F231134
59 amino acids from heme to end
43% to 12A4, 57% to CYP12H1 XP_966937 91% to 12J1
CYP12J3 Ips pini (pine engraver, bark beetle)
No accession number
Pamela Sandstrom
Submitted to nomenclature committee on April 26, 2006
Full length sequence
60% to 12J1 Colorado potato beetle (C-term piece)
44% to 12H1 Tribolium castaneum
clone name EST 28H12
CYP12J4 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 7
90% to CYP12J1 Leptinotarsa decemlineata
heme region
CYP12J5 part 1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 1
80% to CYP12J4 Leptinotarsa decemlineata
PKG to PERF region
CYP12J5 part 2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 31
80% to CYP12J4 Leptinotarsa decemlineata
C-term
CYP12K1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP12K1 Linepithema humile (argentine ant)
No accession number
CYP12K1 Solenopsis invicta (fire ant)
See Solenopsis page
69% to CYP12K1 Linepithema humile
CYP12K1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
66% to CYP12K1 Linepithema humile
CYP12K2 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
56% to CYP12K1 Linepithema humile
CYP12L1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0117K18
46% identical to M. domestica CYP12A2
CYP12M1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
45% to CYP12F2 Culex pipiens
CYP12N1 Bactrocera orientalis (oriental fruit fly)
No accession number
Yong Huang
Submitted to nomenclature committee March 16, 2012
52% to Cyp12e1 Drosophila pseudoobscura
13B Subfamily
CYP13B1 Caenorhabditis elegans (nematode worm)
GenEMBL Z54269 (19692bp) and Z92827 (C29F7)
F02C12.5 also C29F7 has the end of this sequence
Formerly CYP16A1 but renamed after full length sequence
sorted with CYP13
CYP13B2 Caenorhabditis elegans (nematode worm)
GenEMBL Z81565
K06G5
CYP13B2 Caenorhabditis briggsae ortholog
XP_002645617.1 76% TO CYP13B2 70% to CYP13B1
MGLLVCFVAVFAVIASYFKWIHTYWKRRGVDGPVGLPFIGSFYDLADKDKPRGYILHEWTKKFGSIFGYY
EGATPVLVVSDVYVLQEIFIKKFDCFYARKNTNRIHGDLECSQEEPRVNLFAARGARWKRLRSLASPAFS
VRALKQVHNTMENSVLCMIDHMAKHENSAAFNIHEYYQEFTYDVISRLAMGQAYSEQFNNEGVNIVKKIF
MRSNRTLPWYLAVLFPRFQNTVKNFFFKHESIRGGDVALLYKFCEKAVYDRIKERSANAEQEIENDQNDF
IDMFLDYYTEAEIEDAEFGTTVEKKVTSEDVIGSCFVFLLAGFDTTANALAYASYLLAKNPEKMHKAQQE
IDEICTSENISYDDIAKLNYLDAIIKEALRIYPVAWFACSRECVKTTTLGGLVIDKGVRIEADVTALHHS
KEIWGENAEQFVPERWLESSAPRHTMSWIPFGAGPRQCVGMRLGMSEAKTALAHVLRKWSIVAGPETEEQ
LRIQGCTTTSPESVTVYLEARF
CYP13B4 Caenorhabditis briggsae
XP_002645615.1 chrX:17263374-17267448 (+)
MVVSFTIFIVTLFVAVFLYFRKKHKYWSDRGINGPQGLPLLGSFYDVSDANKPRCFVLNEWTKLYGETFG
YYEGTVPVLVTSNLEILHEVFIQKFDYFYARKLTNMLHGDMESLQEEPRVNLFTARGPRWQKLRALTTPG
FSVASLKRLHGKIEESVLRMVELLGEHENDGPFNIHCFFQEFTYDVISRLAMGQQGVKQFENDGIDVVKK
ILLKTHRVLPWYLASIFPQFEFKVKQLFYNHENVRGGKIAELFMYCAKSVMERMKQREKQAAQGEEIQQN
DFIDLFLDHYSEIEQSYNESGKTIKQAC
VVEDVIGSCFVLLLAGFDTTANALGCAAHLLALNPEKMKIAQEEIDEVSNLDNITYEQIGQL
QYLDAVIKESLRLSPVAC
ACSRECVKQTTLGPHLIDEGVRIEADVKAIHYSKEIWGDGTE
LFVPERWFDEQRHPLASLAFGAGKRKCVGMRLGMSEAKMALAHVLRKWSIVAGPETEDQLHFQGCTTTSP
EKVTVHLKARF
14A Subfamily
CYP14A1 Caenorhabditis elegans (nematode worm)
GenEMBL Z50742 (20856bp)
Wilson,R., Ainscough,R., Anderson,K., Baynes,C., Berks,M.,
Bonfield,J., Burton,J., Connell,M., Copsey,T., Cooper,J.,
Coulson,A., Craxton,M., Dear,S., Du,Z., Durbin,R., Favello,A.,
Fulton,L., Gardner,A., Green,P., Hawkins,T., Hillier,L., Jier,M.,
Johnston,L., Jones,M., Kershaw,J., Kirsten,J., Laister,N.,
Latreille,P., Lightning,J., Lloyd,C., McMurray,A., Mortimore,B.,
O'Callaghan,M., Parsons,J., Percy,C., Rifken,L., Roopra,A.,
Saunders,D., Shownkeen,R., Smaldon,N., Smith,A., Sonnhammer,E.,
Staden,R., Sulston,J., Thierry-Mieg,J., Thomas,K., Vaudin,M.,
Vaughan,K., Waterston,R., Watson,A., Weinstock,L.,
Wilkinson-Sproat,J. and Wohldman,P.
2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
elegans.
Nature 368 (6466), 32-38 (1994)
K09A11.2
CYP14A1 Caenorhabditis briggsae ortholog
XP_002645575.1 85% to CYP14A1
MSVFILAVLVFLVLYVVHFYWKVSKYPKGPFPLPLIGNIHQ
FPPDHVQLYFDEMSKIYGPCFTVWIPYPAIVLNDYEHVKEAFVTQ
GDTFTYRAHRSPETLLPVHDHTGILASDGDHWRLQRRTSLKILRDFGLGRNLMEEQVVRS VQEMMVQIENITDKNKVDMFWPIQLCVGNVINETLFGFHYKYEDSEKFKTFVRIVDKHLR HLQGTMPLLVSAFPWLRHLPIIGDIGYHNIKNNISS
YQTFIEEEVTTQVKQYDGVSEPENFVHAYMQQMKQTGNPGLE
IKNLCASVLDFWLAGMETTSNSLRWHLAYMMKYPEIQDKVRKEIFEVVGTSRLPSMSDKP
NMPYTQAVIHEVQRCSNMLPFLGSHQ
CVEETSIKGKHVPAGTLVFAQIWSVMKNDPVFKDASEFNPDRYLQSDGKTFDK
AVLEKTIPFSIGKRNCVGEGLARMELFLIFSALIQKYEFVPTSNIDLSPDWGVV
MTSKPYTCQLLPQY*
CYP14A2 Caenorhabditis elegans (nematode worm)
GenEMBL Z50742 (20856bp)
see CYP14A1 for reference.
K09A11.3
CYP14A3 Caenorhabditis elegans (nematode worm)
GenEMBL Z50742 (20856bp)
see CYP14A1 for reference.
K09A11.4
CYP14A4 Caenorhabditis elegans (nematode worm)
GenEMBL Z50742 (20856bp) Z70212(R04D3.1 continuation of Z50742)
see CYP14A1 for reference.
after K09A11.5
partial sequence at end of cosmid continues on cosmid R04D3
CYP14A4 Caenorhabditis briggsae ortholog
XP_002645581.1 X - 17002025-17004199
MSLLIISFVLITVVYIINFYWEVRKYPKGPFPLPLIGNIHQ
IPDDKLEVWFDDLSKTYGPIFTVWSPLPCVVITDYAHIKDAFVTQ
GETYTYRAHRPPESLLQPHDNTGILNSSGENWRLQRRTSLKILRDFGMGRNLMEEQIVKS IQEMMEQLAKSMDKKKAEIFWPIQLCVGNVINEFLFGFHYKYDECERFKKFVNVVDYHLR ILLGKCSLSVSAFPWLRHVPIIGELGYHRIKRNIKT
YQSFIEEEVEKQLEKFDTESEPENFVHAYLQQMKQTGHPGLD
MKNLCACVLDFWLAGMETTSNALRWHIAYMMKHPVIQENVRKEILDVVGTSRLPS
MSDKPKMPYTQAVIHEVQRHSNMVPFLGTHQ
SVQETEILGKKIPAGTNVIAQTWSVMKNDPIFVNHLEFNPSRYLLADGKTFDK
VVLERTIPFSVGKRSCVGEGLARMELFLIFTALIQKYEFIANGPVDMSYNAGAV
LTIKPYTCEMRKVF*
CYP14A5 Caenorhabditis elegans (nematode worm)
GenEMBL U64847
F08F3.7
CYP14A6 Caenorhabditis briggsae
XP_002636088.1 V + 4415831-4417561
MSVFIVAFFSFIAAYIVHFYWKVSKYPKGPLPLPFVGNLLQ
FPATHIQTFYDDLAKTYGPCFTLWTPTPSVVITDYDHLKEAFVTQ
GDAFITRGLRPPETLLHPDVDTGIVFSNADTWRVQRRTSLKILRDFGLGRNLMEEQ
VTRSVHEMLQQLDNIKDKTDVDMYWPIQLCVGNVINESLFGYHYSYKDTEKFQKFVMIVD
RHLKNLSGRPQLLIAAWPWLRHVPIIGEMGYHSIKRNIKT
YHKFIEDEVASQIKEYDEHSEPENFVHAYMKQINQAGNPELN
MTQLCASVLDFWIAGMETTSNSLRWHLTYMMKYPEIQDKVRKEIFDVVGTNQLPSMSDKP
NMPYTQAVIHEVQRHSNMIPMLGTHF
NTKEINIKGYKVPTGTNCIGQLWSIQRNDPVFIESHKFNPSRYFQADGRTMDKAVLEKTIPF
SIGKRNCLGEGLARMELFLIFSALIQKYEFVPKSSIDLSPVWGGVLTSKPYRCQLVPQTA*
CYP14A6-de6b Caenorhabditis briggsae
V + 4420005-4420127
AVLEKIIPFTIGKRNCFGEGLARMELFLIFSALIQKYEFCA
CYP14A7P Caenorhabditis briggsae
XP_002645576.1 X - 16978293-16979463
KVDMFWPIQLCVGNQ
INESLFGYHHKY
CDADRFKTFVQDLDRHLRLIQARLPLLMGAFPWL
RQVPIIGELGYHKIERNVKQ
YHKFIEEEVTSQMKEYDGESEPDNFVHA*QHIKQTGNPGXXXXX
NLCASVLDFWLAGMETTSNSLRWHLAYMMKYPEIQDNXXXXXXX VVGTSRLP*MSDKPNMPYTQSVIHEVQRQSDMIPLLGTHK
XXXXXXXXXXXXXXXXXXXXX
QIWSIMNDDSVFEENHKFNPSRYLQADGKMLNK
ALLERTIPFSIGKRNCVGEGLARMELFLIFSAVIQTYAFIPNSNIDLSPDWGAVLTSKP
YTYQLIPQTLYYFVK*
CYP14A8P Caenorhabditis briggsae
XP_002645579.1 X - 16995892-16996323
FPGQNIHIYFDDLSKTYGPCFTLWTPLPAVVITDYDYLKGAFVNQ
GEAFIMRAERPPETLLQAHLNTGILQSSGENWRL*RRTSLKILRDFGLGRNLMEEQVMRS
VHEMLYQIGNITDKKKV
CYP14A9 Caenorhabditis briggsae XP_002645579.1 X - 16996539-16998309
MSVLIVAFLVFVITYIAHFYWKVSKYPKGPFPLPLIGNVLQ
FPDKNIHIYFDELAKTYGPCFTLWTPLPAVVITDYDYLKDAFVTQ
GEAFIMRAERPPETLLQPHINTGVLASSGENWRLQRRTSLKILRDFGLGRNLMEEQVMRS VHEMLHQIENITDKKKVDMFWPIQLCVGNVINESLFGYHYKYEDADRFKTFVQVVDRHLR AITGKIPLLMGAFPWLRHVPIIGEHGYHKIARNIKQ
YQGFIEEEVASQIKEYDGESEPDNFVHAYMQQMKQTGNPGLEF
MPNLCASVLDFWLAGMETTSNSLRWHLAYMMKYPEIQDNVRKEIFEVVGASRLPSMSDKPNMP
YTQSVIHEVQRHSNMIPMLGSHT
NTEDIIVKGQNVPTGTVIFAQVWSILKNDSVFDESHKFNPSRYLQADGKTLNK
AVLERTIPFSIGKRNCVGEGLARMELFLIFSALIQKYEFVPN
DNVDLTPVWGGVLTSKPYTCQLIPQAV*
CYP14A10 Caenorhabditis briggsae
XP_002645580.1 X - 16999284-17001021
MSVLIIAFLVFIIAYIAHFYWKVSKYPKEPFPLPFIGNFLQ
XXXXXXXXXXXXXX
KMYGLCFTLWAPLPAIVITHYDYLKDAFVTQ
GDAFITRINRPPETLPQAHNNTGVLVSSRENWRLQRRTSLKILRDFGLSRNLMEEQVMRS VHEMLQQIENINDKKKVDMFWPIRLCVGNVINESLFGYHYKYDDADRFKNFVQIADRHLR AALGKLQLLMTAFPWLRHVPIIRELGYHKIGTXXXX
YQGFIEKEVANQIKEYDGESEPENFVHAYXX
QMKQTGNPGLE
XMPNLCS
SVLDFWLAGMETTSNSLLWHIAYMM*YPEIQDKVREKIFEVVGTSRLPSMSDKPNMPYTQ
AVIHEVQRHSNMIPVMLFHT
XXEDVVVKGQNVPTGTLVFGQIWSIMKNDSMFDESQKFNPSRYLQADGKTLNN
AVIEKKIPFGIGKKACAGEGLARMELFLIFSAFIQKYEFIANSNIDL
SPDWGGVLTSKSYTCQLIPQTV*
CYP15A1 Diploptera punctata (cockroach)
GenEMBL AY509244
Helvig,C., Koener,J.F., Unnithan,G.C. and Feyereisen,R.
CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl
farnesoate to juvenile hormone III in cockroach corpora allata
Unpublished
CYP15A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970303
44% to CYP15B1 Anopheles, 48% to CYP15B1 Aedes
note: CYP15A1, B1 and C1 are all probably orthologs.
Each species seems to have only a single CYP15.
MLFFVTLVISLVLLFLILDTIKPRRYPPGPKWLPIVGNFLEFRRRLSEIGYHHLVWKEFSEEYGDVVGLK
MGRNLVVAVFGAEAVKEVLTREEFDGRPDGFFFRLRTFGKRLGIVFSDGQFWQKQRKFSMQHLRNFGFGR
KEMEEKIEEETKDLIAVFKKQCSEPIWMHTAFDVSVLNVLWAMMAGERFNINDERLRKLLKIVHDAFRLT
DMSGGMLNQLPFLRFIAPETCGYNQLVDVLVRMWEFLQETISEHRKTLCSSHARDLIDAFLQKMDIQSDS
SFTDDQLMSLCLDLFMAGSETTSNTLGFSVVYMLQFPEVQKKVQDEMDEVVGRNRWPTLQDRIKLKYTEA
VLMEIQRRANIPPLGIAHRATRDVSLFDYRIPEGTIVLTSLYSVHMDHKFWKDPLAFRPERFLNKEGNLE
VDEKYFAPFGYGKRRCLGESLAKANYFLFFTALLHNFYLEKDCDGPEPQLEGYDGVTISPKPFRAKLIPRTD
CYP15A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
59% to CYP15A1 Tribolium castaneum
CYP15A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph15, 49% to 15A1 Tribolium
Pediculus genome site
CYP15A1 Apis mellifera (honeybee)
CYP15A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP15A1 Linepithema humile (argentine ant)
No accession number
CYP15A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
73% to CYP15A1 Linepithema humile
CYP15A1 Solenopsis invicta (fire ant)
See Solenopsis page
72% to CYP15A1 Linepithema humile
CYP15A1 Pogonomyrmex barbatus (seed-harvester ant)
No accession number
Reed Johnson
Submitted to nomenclature committee June 3, 2010
75% to CYP15A1 Linepithema humile
CYP15A1 Reticulitermes flavipes (termite)
No accession number
Michael Scharf
Submitted to nomenclature committee Feb. 19, 2009
Clone name RfCyp15A1-2
69% to Diploptera punctata CYP15A1
58% to CYP15A1 Tribolium, 48% to 15B1 Anopheles
CYP15A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
53% to CYP15A1 Pediculus humanus, C-term
CYP15A1 Coptotermes formosanus (Formosan subterranean termite)
No accession number
Matt Tarver
Submitted to nomenclature committee Sept. 8, 2011
93% to CYP15A1 Reticulitermes flavipes
CYP15A1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
3 disconnected pieces 60% to CYP15A1 Acyrthosiphon pisum
CYP15A1 Acyrthosiphon pisum (pea aphid)
LOC100162751
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
49% to CYP15A1 Tribolium, 51% to CYP15A1 Diploptera puncatata
52% to CYP15A1 Reticulitermes flavipes
CYP2 clan
MFFVAVVISVFIIVCILDIITPHKYPI (1) GPTRVPLLGNYLE
IRKLRNKLGFYHLVWDHLAKYYGKVFSVKLGRIEAVVVSGYDAVRQVLCKDDFDGRPDGFFFRFRAFYKRLGIVFVDGPTWTEQRKFCMQHLRKMGFGGDLMERIIIEEVNDLMLDISRKCENGKPIEVYGLFDVSVLNGLWAMLAGHRFALNDSRLARLMELVHVSFRMLDMSGGILNQMPFIRFFAPKCSGYKYLKQIINEFYTFLKESVEEHKCRANDQEDDFISAFLKEIEKNKESPGSFSEEQLLVILLDLFLAGSETTSSMLSFVILLLLKHQDIQAKVHAELDAVVGDREIHLADKNRLNYLEAVLMEVQRHSNVAPLAIAHRTIRKTSLQEYTIPKDTLVLASIWSVHMDEQHWGDPKVFRPERFLDSSGKIINDSWFMPFGVGRRRCLGEILAKTNIFMFIAKLIQHFEIRIPQGAQLPDKPQDGVTISPSPFSAIFIPRRCLSQ.
CYP15A2P Acyrthosiphon pisum (pea aphid)
LOC100169165 whose N-term 100 or so aa are wrong
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
49% to CYP15A1 Tribolium
87% to CYP15A1 aphid
missing N-term exon, revised middle
Since the rest of the protein is so conserved (87%), the N-term exon
seems to be gone. Therefore this is probably a pseudogene.
CYP2 clan
GPSRIPFIGNYLEIRKLRNELGFYHLVWHQLAKCYGQVFSVKLGRIEAVVVSGYDAVRQVLCKDDFDGRPDGFFFRFRAFYKRLGIVFVDGPTWNDQKKFCMQHLRKMGFGGDLMEKIIIEEVHDLMVDITIKSENGKPIKVHGLFDISILNGLWAMLAGQRFALNDSRLARLMELVHVSFRMLDMSGGILNQMPFIRFLAP
NSSGYEHIKQILNEFYTFLK (0)
ESVEEHKCG
ENYQEDFISAFLMEIEKNKESPESFSEEQLLVILLDLFLAGSETTSSMLSFAVLLLLKHQDIQDKVHAELNAVVGDREIQLADKKKLNYLEAVLMEVQRHSNVAPLAIAHRTIRKTSLQEYIIPKDTLVLASIWSVHMDEHHWGDPEVFRPERFLDSTGNIIKDSWLMPFGIGRRRCLGEILAKANVFMFIANLIQNFEIRIPNGVQLPDRPQDGVTISPSPFSAIFIPRR.
CYP15A3P Acyrthosiphon pisum (pea aphid)
LOC100160402p
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
44% to CYP15A1 Tribolium, 79% to CYP15A1 aphid
middle region revised
missing N-term exon
Since the rest of the protein is so conserved (79%), the N-term exon
seems to be gone. Therefore this is probably a pseudogene.
CYP2 clan
GPTRVPLLGNFLEIQKLKNKLGFYHLVWDKLAKCYGQVYSVKFGPIETVVVSGYDAVREVLSKDDFDGQADGFFFRTRAFYKKLGIVFVDGPMWTEQRKFCMRHLQKLGFCGDVMEKIVIEEVNDLVLDITRKYENGKSIEVRGLFEVSVLNGLWAMLAGGRFSLNDSRLARVVELIHESLRILDMPGGILNQWPFIRYLAP
LSRNKHLKQIINELYILLK (0)
ESVEEHKCSENDQE
DFISAFLMDIEKNKKSLGSFSEEQLVVILLDLFLAGSETTSITLSSVILHLLMNQDIQTKVRAELDAVIGDREILPSDRKRLNYLEAVFMEVQRHSNVVPLAIATNRTIRKTTLQDYIIPKDTLVLASIWSVHMDEQHWGDPEVFRPERFLDSKGKIINDSWLMPFGVGKRRCLGEKLAKTYIFMFIAKLIQHFEIRIPTDIQLPDKPQNGVNISQTPVSVFFIPRRCLKAN
CYP15B1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPj2l3
47% identical to 15A1, though this is probably the ortholog of CYP15A1
CYP15B1 Aedes aegypti (yellow fever mosquito)
CYP15B1 Culex pipiens quinquefasciatus (southern house mosquito)
XM_001864994
locus_tag="CpipJ_CPIJ014944
72% to CYP15B1 Aedes aegypti
MRKPAFFPPGPAWFPLIGCGYRVFKLVNVHKFYHLMWDALARRY
GPVVGLKLGRDRVVIVSGLAAIREFYSKEAFNGRPNGFFFRIRSFNKRLGLVFNDGAD
WDVQRRFSVKTLKSLGMGRTGMVHSLEKETEELIHHLRKLSRGGRTIQMHSAFDIAVL
NVIWTLLAGNRFKLDDKRLAWICDTIHNSFRVIDMSGGVLNQCPPIRHICPNKSGFKP
LVNLLNPLLNFINDTISNIKANPECPERHNCLISSYLEELQIDNPHPSFSNEQLLSLC
LDLFQAGSETTSNTLGFGVAHVMHHPNVIAKIHQELDNVVGRYRLPTLDDRPSLPYLE
ATICEIQRIANVAPLAIAHRTTSPVQLGQYVIPRDTIAMVSLYSIHMDRQYWGDPEVF
RPERFLNESEDKLIQHEYFLPFGAGKRRCLGEALAKSNLFLFFAAFMHAFIVEPANPG
QLPPLEGFDGITLSPQPYQVRLKERLI
CYP15B1 Culex pipiens
CPIJ014944
CYP15C1 Bombyx mori (silkworm)
BAAB01071346.1 BAAB01157546.1 BAAB01036905.1 BAAB01022841.1
BAAB01157214.1BAAB01068330.1
40% to CYP15
note: CYP15A1, B1 and C1 are all probably orthologs. Each species
seems to only have a single CYP15. (not found in Drosophila)
See silkworm page for sequence
CYP15C1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
CYP15C1 Plutella xylostella
Gene number CCG011481.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
60% to CYP15C1 Bombyx mori
CYP15D1X Daphnia pulex (water flea)
renamed CYP370A1
CYP15D2X Daphnia pulex (water flea)
renamed CYP370A2
CYP15D3PX Daphnia pulex (water flea)
renamed CYP370A3P
CYP15D4X Daphnia pulex (water flea)
renamed CYP370A4
CYP15D5X Daphnia pulex (water flea)
renamed CYP370A5
CYP15D6X Daphnia pulex (water flea)
renamed CYP370A6
CYP15D7X Daphnia pulex (water flea)
renamed CYP370A7
CYP15D8X Daphnia pulex (water flea)
renamed CYP370A8
CYP15D9X Daphnia pulex (water flea)
renamed CYP370A9
CYP15D10X Daphnia pulex (water flea)
renamed CYP370A10
CYP15D11X Daphnia pulex (water flea)
renamed CYP370A11
CYP15D12X Daphnia pulex (water flea)
renamed CYP370A12
CYP15D13X Daphnia pulex (water flea)
renamed CYP370A13
CYP15E1X Daphnia pulex (water flea)
renamed CYP370B1
CYP15E2X Daphnia pulex (water flea)
renamed CYP370B2
CYP15F1 Reticulitermes flavipes (termite)
No accession number
Michael Scharf
Submitted to nomenclature committee Feb. 19, 2009
Clone name RfCyp15A1-1
43% to CYP15A1 Tribolium, 38% TO CYP15B1 Anopheles
CYP15F1 Coptotermes formosanus (Formosan subterranean termite)
No accession number
Matt Tarver
Submitted to nomenclature committee Sept. 8, 2011
83% to CYP15F1 Reticulitermes flavipes
presumed ortholog
CYP15F2 Coptotermes formosanus (Formosan subterranean termite)
No accession number
Zhou Xue-hai
Submitted to nomenclature committee March 30, 2013
54% to CYP15F1 Coptotermes formosanus
53% to CYP15F1 Reticulitermes flavipes
16A Subfamily
CYP16A1X Caenorhabditis elegans (nematode worm)
GenEMBL Z54269
number retired
This sequence is now CYP13B1
CYP16A1 Tetraodon nigroviridis (Green puffer)
EMBL CAAE01014752; GenPept CAG04908.1
CYP26 clan new P450 family in vertebrates
NEARBY SEQS: (seq -1) 5-hydroxytryptamine receptor 4-like (HTR4)
(seq +1) dual specificity phosphatase 4 (dusp4)
NOTE: DANIO CHR21 HAS THESE TWO FLANKING GENES WITH region between
That is unmarked from 15.72-15.835 Mb Ensembl numbering
21.42-21.52 Mb on Zv8 UCSC browser (blastx shows no P450 in this region)
Danio has lost this gene
MSKLPGNAGVSVLGDKSLEFYRDPVTFCRQRMEKHRSRVFQCRLLNRPTVFICSVRGVRELLS (1)
EKSSVFVKDPTDLMTNVYGDTVVTTN (1)
GEEARLLRLSLASLLTGSSLESWSGYIGS (2)
VCQQHLKDLSVS (2)
GQPQCAYSIFKRLGTELVLGLFLNVRAEEQPELYQEIVQLCTQHWH (1)
GLISAPLNVKSPLWSSGFSVALEARDTLMEIIKNKLQSDKQG (2)
FVGALASLPLPDSSCASQHLLLFISALIPKALASLLTSFSLVLAEDKQ (0)
ARQRAAQDPEYLHGVLMEVQRLWPPFIGGRRLCDQ (0)
DTTIAGFHVPKGHGAIYISYAVHRDPDVFQQPDRFLPERWSGS (2)
NAGQEQLLCSFGGGPRSCIGFNLTGVFLK (0)
EACTYLLKHYDWRLDPPSQDLGYKWLPVSRPADPPTISFIRLDEAGCDGSGAGL*
CYP16A1 Takifugu rubripes (fugu)
Fugu also has this gene next to HTR4
88% to Tetraodon nigroviridis
MSKLPGNAGVSVLGDKSLEFYRDPISFCRQRMEKHGSRLFLCRMLNRPTVFICSVRGVRELLC (1)
EKSSVFVKDPTDLMTNVYGDTLVTTN (1)
GEEACLLRLSLTSLLTGSSLESCSGSISS (2)
TCERHLKDLS (2)
GRPQCVYSVFKRLGTELVLGLFLNVRAEEQPELYQEIVNLCTQHWH (1)
GLISAPLNVKSPLWSSGFSTALEARDKLMDIIKNKLQSDKQG (2)
FVGALGSLPLPDSSCAPQHLLLFISALIPKALASLLTSFSLVLAGDEQ (0)
ARGRAAHDPEYLHGVLMEVQRLWPPFIGGRRLADQ (0)
DSTIAGFKVPKGHGAIYVSHAVHRDPDVFQQPDSFLPERWSGR (2)
NAGQESLLCSFGGGPRSCIGFKLTNVFLK (0)
EAFSYLLQHYHWRLDPPSQDLEYKWLPVSRPADPPTISFSRLDQTGSDGSGAGVL*
CYP16A1 Oryzias latipes
EST AM345752.1 N-term 148 aa
Genomic region between DUSP4 and HTR4
MAKLPGSAGVSLFGDKSLEFYRDPVSFCQQRIHKHRGRVFQSRLLNRPTVFVCSVRGMRELLG 65494
EKNHIFLKDPTDLMTNMYGDTIVTTN (1)
GEEACLLRLSLTSLFRETSLESTREYVSS (2)
VCERCLKDLSLR (2)
GQSECVYSVFKRLGTELVLGLFLNIRAEEQPDLFQEIMQLCTQHWH (1)
GLISAPVNLKVPLWSSGFSTALEARDRLMDIIKDKLENDTEG (2)
FPVTLSSLPLPDSSAAAQHLLLFISALIPKALASLLTSFTLVLSADEQ (0)
SRRRAVEDSDFLHTVLLEVQRLWPPFIGGRRIADQ (0)
DTTLAGFEIPKGYGAIFISHSVHRDPEVFQQPDSFLPERWSGR (2)
NAGQEGFLCSFGNGPRSCIGSKLTDIFLK (0)
EACMFLLKRYDWRLDPPSQDLTYKWLPVSRPANPPTVSFTQVDQSVSDRRNARDVINNGPVVC*
CYP16A1 Gasterosteus aculeatus (three-spined stickleback)
chrXIV:9154271-9168725 UCSC browser
76% to Tetraodon CYP26 clan memberMAKLAGSAGVPVLGDKSLDFYRDPVGFCQQKIDKHRGRVFQCRVLNRATVFVCSVRAMRELLC (1)
EKSNTFQKDPTDLMTNMYGDTVVTTN (1)
GEEAYLLRLSLTTLFTGSCLKSSNDYITS (2)
VCERHLKDLSLS (2)
GRPPCLYSAFKRLGTELVLGLFLNVRAEEQPQLFQEIVQLCTQHWH (1)
GLISAPVNVKVPLWSSGFSNALDARDRLMDIIKDKLKNDTQG (2)
FVGSLGSLPLPDSSSASQHLLLFISALIPKALASLLTSFTLALSGNEQ (0)
HRRRAAEDPDYLRRVLLEVQRLWPPFIGGRRIADE (0)
DSTLAGFHVPKDYGVIYISHSVHRDPEVFEQPDHFLPERWSGR (2)
NAGQEHFLCSFGNGPRSCIGTKLTDVFLK (0)
EACMYLLKNCDWCLDPPSQDLEYKWLPVSRPAHPPAISFTRLDAAGCDGSDTS*
CYP16A1 Squalus acanthias (dogfish) Dogfish Shark
Rectal Gland EST EG360444.1
51% to Tetraodon CYP26 seq N-term
MSQIQIPGSSGYALMSDRSLEFYKDPMHFCNSRIHSNGSRIFQARLLNKPTIFVCSVKGMKELL
CEKVNVFDTSYTTSMCKLFGDTVCFTNGEEAQLLRMSLMQLFRGKALDTYADYINRVCTR
NLKDLSLSSEPIAVYTLFKRLATELVLGIFLNVDAEESAALSKQITQLSTQHWHGLISAP
VNLKVSVWSSGFSQALEAKEKLLNII
CYP16B1 Branchiostoma floridae (amphioxus)
EST FE555348,
In genome near HTR4
note this gene has one extra intron in exon 6
45% to stickleback CYP16A1
MAELPGYVGYPWVGDNSLEFYRDPVSFMEKRIQDYSSRIFQARFINRPTVFVGSAEAVKKLLN (1)
EKTQHFEMGYKALWQGLYGDNVLFSD (1)
GTEAIALRALLIPLFNKEAVSGYQSTVES (2)
ICDRTLQTIPTG (2)
RPVKVYELLKQMSTEISMGLFLDIERETDNSFAPLVSQLMTQHWH (1)
GIISMPANLKLPTWGGNWESGYSKALEAK (0)
DELLKIIGDRIGKNKHK (2)
NVLGLMKTAGFRSEDEVYRHLLLFVSALVPKAFSSLFTSFTLQLAGPSK (0)
ASMRQKALEDETFLEHILLEVQRLWPPFIGGRRLVRQ (0)
EFTLAGYRIPKEHGLMYVTHTAHRDPQIFPEPNSFKPERWSTS (2)
NAGHEEYLCAFGGGPRRCIGTQLVQLVLK (0)
HVTKYLLHNFHWEVTQAEIPPYKWLPVSRPTVEDQVIFTPRDSPDQEVEVGVEVAETSL*
CYP16C1 Saccoglossus kowalevskii
XM_002739846
ESTS FF475723.1, FF439894.1, FF465259.1
CYP26 clan
beach area of Waquoit Pond near Woods Hole, MA
45% to CYP16B1 branchiostoma
MAHLKGHIGYPIIGDKSVEFYKDPIEFVNKRVNEFDEKIFQSRV
LNTPTVFIASAEGVRQLLYEKSHNFEMGYRAFMYNLYGDNLLFSGHDEAHRIRSVLHH
LFSGESVQQWDSLLEKLMNRNFDRLDSGCALPMYKVFKRFCTELSISIFLDVDIESSL
ELVQETTDLATTHWHGIISVPFSLKVPYWSSGFKKAIEAKNSLFEIICKRLVQTVDGD
FLQQIKSAGFKDMTEAAHHVLLFISALVPKAMASLLTSFTILMAEKDYITHCEKACRD
EQYLQYVLLEVQRLWPPFLGGRRLASQDCEIGGFKIPKGYAAAYITYSAQRDPKIFPD
PDEFRPERWRTCNAGNENYLSCFGGGPRDCVGSSLMNRMLKT
VCKYLLNHYSWLVPNGQDLTHKWLPVSRPKQQVMVVYELKSDLEQSSEFTEVDDPDIHS
CYP16D1 Nematostella vectensis (starlet sea anemone, Cnidarian)
XM_001623765.1
ABAV01025394 C-term exon
ABAV01025395.1
ESTs FC299001.1, FC299002.1
45% to CYP16C1 Saccoglossus kowalevskii,
42% to Branchistoma CYP16B1, 40% to CYP16A1 fish
MSSLPGHIGWPVTGDKTIEFSKNPTQFVKGRITEYESRIFQTRILNKPHVFVASSQGVKEVLQ (1)
DHSYAFTMGYKDFGYMYSLYGDLLLFNDSDEATRLKRILCSVLQPHQMAQCLAEVDTICSRVLVNLHT
EPVSLYKTFKTVTTQICLTLFLGLDFEEAQTEAGQIVDLTIQHWN (1)
GLISLPVYFNVYGQKSGYSKAMLAK (0)
NRLLEVINKQLLEVADLDG (2)
TIIGTLKEAGFVSRSELANHLLLFVSALVPKALASLLTSFCLELAKPRN (0)
NGMQERAAKDDLFLDDALLEVQRLWPPFLGGRRIARQ (0)
DVVIDGYRIPSGYHVAYLTKASNTDPSIFPGPNHFDPKRWRTS (2)
TGDDCDRVWTFGAGPRKCVGHAFNNKIIK (0)
FVMRYLLRYYKWSLPEDQDLTYKWLPVSRPKHDVQVAFTKKTADFL*
CYP16E1 Molgula tectiformis (anural ascidian)
ESTs CJ343788.1, CJ333781.1
43% to CYP16G1, 42% to CYP16A1 fugu
IKTRVINVPTVFVCSYSGVNELLNEKSENFDHGYQSFLFNSYGDNILFENGKEAETLHKT
LSKIFTNCENYFPRIANIIKPSIKEFFNEVDDVYQLSKSIMTKVCLVTFLDLDETNKELI
ETISQLSTLHWHGIISLPLNIKTPFA
KSTWNKALDCKEKLLKIIKEQSQLYNNNMEPSFFQELLENFKSTSLHNHILLFISALIP
KAFASLFTSFIFELSGEDKAGMRERCLKDELFLKHVLFEVQRLYPPFLGGRRLANKDTTI
GKYKIPKGYSVFYIAHHAHRDKTIFKDPLKFLPSRWEGNEADNPGLFCFGSGKRECIGVH
LITKILMFAAQELLQQSNWVTRPTDVEYKRLPIARPLNPVQVWFFTK*
CYP16F1 Strongylocentrotus purpuratus (purple sea urchin)
EST BG786093, N-term from UCSC Browser
80% to CYP16F2, 48% to CYP16C1
MATLKGKIGYPILGDSSVEFYRNVPLYVNSRIEEYGARIFQARILNKPTVFVCSANAVKE
LLTGNT ()
MDLGYKAMLHHLYGDNIMFEEAAEANRLHALMHHVFIQNALLNFDSI
SGIPWSTHASDSADLVHDVASLATTHWHGVISVPMNWSVSYWSSSCKRAVEAKDKLLERI
RDRLASQTDEGSFLTRAREAGFKNHAELEQHILPFVSALVPKAIASLLASFTLALCSENQ
EDMQEKARESSDYLDWCLLETERLWPPVLGGRRLVREDFVLDGYKVPKGYAVIYVSSIAH
RDPNVFKNPNSFDPTRWANKRTEKEKLLFCYGDGPRCCVGTFLMKNLIKKVSQYLVGHYN
WTLXDQEEDLDYN
CYP16F2 Paracentrotus lividus (sea urchin)
EST AM505877.1
80% to CYP16F1, 46% to CYP16C1, 44% to CYP16D1
AKERLLEVIRERLASHQDEGSFMARASQAGFKDKAELEQHILPFVSALVPKAIASLLASF
TLALCSQNQEHMQDKARESKDYLDWCLLEIERLCPPVLGGRRLVKEDFVLDGYRIPKGYA
VIYVSSIAHRDPKVFKNPTKFEPTRWADNKEKKKLLFCYGDGPRCCVGTSLMRNLIKTVG
SYLVGQYNWTLRDQNEDQDYKWLPIARPRELTVSFTRIDQSKTLSDLAVSNGTKSDQSDT
LSNGTS*
CYP16G1 Ciona intestinalis
SEQUENCE 180 on the sea squirt page
45% to CYP16B1, 45% to CYP16E1
MKVPGTIGYPIIGDKSREFLSDPTKFITSRINEH
SSRIFQCRILNNPTIFVCSPQAVKKLLSKEMANDIEHGYKSILHRLYGDNIVFENDVTAN
ELHNCLRNCFQNMELYKETVNRLCE
PLLSSLHLRTEPVYIYPEFKRVMTRMCLELFLGIKTESCLDQTEEITHLATQHWHGIISV
PVSLKIPLAGESTYSLAVQAKEKL
LSIIRSILLGQNGQGDASVAAKLRHADFSNSKSLEQHLLLFVSAVIPKAFASLITSFIIV
MAGDDKEALRARARTDSKFLDRVLLEVERMWPPLFAGRRLVRRTTTLESYDLPKDYAIMY
VTHAAHRDPEVFPEPNSFNPDRWITCNAGQEDLVLCFGSGPRCCVGTDLIRRILRDVASR
LLQNYEWSLAPPNQDTSYKYLPVARPAVQPSIAFSSYLTNDEPFFDACG*
CYP16G2 Ciona savignyi
paired_scaffold_186 ortholog of seq 180
70% to CYP16G1
681879 MKVPGTIGYPVIGDKSMEFL 681820
681640 RNPSSFIQSRIEQHSSRIFQCRFLNNPTIFVCSAQGVKTLLSQ 681512
680673 DMIEDIEHGYKSILHRLYGDNIVFENGLDSIELHHCLTNCFKDVENYTETV 680521
XXXXXXXXX
679207 NTLHRSAPVPVYSEFKKLMTRLCLKLFLDIEGEEASDEVTELATQHWH 679064
678445 GIISVPVFVKLPLAGQSTYSLAIQAKEKLLSLIRSLLQRQANSGX 678314
677760 ASVASKLRRADFPNGSTLEQHLLLFVSAVIPKAFASLITSFITALAGEDK 677611
676148 AEMRHRARNDAGYLDHVMLEVERMWPPLFAGRRLVKRHTNLLGYRLPK 676005
675441 DYAILYVSHAAHRDPDVFPEPDLFNPDRWDTX 675349
674535 NSGQEGLICCFGSGPRSCVGTSLIRRILRDVASRLLQDYDWSLSPPNQDTSYKYLPVARP 674356
674355 ARQPTLRFASCADDNDDHFYDACG 674284
17A Subfamily
CYP17 human
GenEMBL M14564
Chung,B.C., Picado-Leonard,J., Haniu,M., Bienkowski,M., Hall,P.F.,
Shively,J.E. and Miller,W.L. (1987)
Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase):
cloning of human adrenal and testis cDNAs indicates the same gene
is expressed in both tissues
Proc. Natl. Acad. Sci. U.S.A. 84, 407-411.
First human CYP17A1 cDNA
CYP17 human
GenEMBL M19489
Picado-Leonard J, Miller WL. (1987) Cloning and sequence of the human
gene for P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase):
similarity with the gene for P450c21.
DNA. 6. 439-448.
First human CYP17A1 gene
CYP17 human
GenEMBL NM_000102
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL
DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLV
PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
CYP17 human EST
GenEMBL Z19875 (235bp)
UK-HGMP (United Kingdom human genome mapping project)
covers amino acids 270-348 when translating the complementary
strand. The fragment goes through at least 6 frame shifts.
sequence ID AAAAWEO
CYP17 human EST
GenEMBL Z20209 (248bp)
UK-HGMP (United Kingdom human genome mapping project)
covers amino acids 265-349 when translating the complementary
strand. The fragment goes through at least 8 frame shifts.
sequence ID AAABPSZ
CYP17 human
GenEMBL S85459 (556bp)
Biason,A., Mantero,F., Scaroni,C., Simpson,E.R. and Waterman,M.R.
Deletion within the CYP17 gene together with insertion of foreign
DNA is the cause of combined complete 17
alpha-hydroxylase/17,20-lyase deficiency in an Italian patient
Mol. Endocrinol. 5, 2037-2045 (1991)
CYP17A1 Pan troglodytes (chimp)
NM_001009052
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATL
DIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNIIQNYNEGIIDNLSKDSLVDLV
PWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTQV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST
CYP17A1 Macaca mulatta (rhesus monkey)
NM_001040232
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL
DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLF
PWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
CYP17A1 Macaca fasicularis (cynomolgus monkey)
DQ074802
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP17A1
94% to human, missing first 9 aa
MHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKD
FSGRPQVTTLDILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEI
STLCDMLATHNGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDS
LGKESLVDLFPWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFHSDSITNMLDVL
MQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQV
KKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIG
EFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPR
SCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQA
WREAQAEGST
CYP17A1 Papio hamadryas ursinus (chacma baboon)
AY034635, AF297650
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL
DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLF
PWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFRSDSITNMLDVLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHV
IINRWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
CYP17A1 Papio cynocephalus (yellow baboon)
AF458331
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLP
RHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTL
DILSNNRKGIAFADYGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATH
NGQTIDISFPVFVAITNVISLICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLF
PWLKVFPNKTLEKLKRHVKTRNDLLTKIFENYKEKFRSDSITNMLDVLMQAKMNSDNG
NAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQ
NVGFSRTPTISDRNRLLLLEATIREVLRIRPVAPMLIPHKANVDSSIGEFAVDKGTHV
IINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSLSYLPFGAGPRSCIGEILARQ
ELFLIMAWLLQRFDLEVPDDGQLPSLEGNPKVVFLIDSFKVKIKVRQAWREAQAEGST
CYP17A1 Canis familiaris (dog)
XM_535000.2
78% to CYP17A1 human
MWELLVFLLFTLVYFLWPKSKCPNAKYPRSLPSLPLVGSLPFLPRDGHQHVSFFKLQKKYGPIYSFRMGTKTTV
MVGHHQLAKEVLIKKGKEFSGRPRVVTMDILSDNQKGIAFADHG
ASWQLHRKLALATFALFKDGNQRLEKIICQENSLLCDFLATQNGKSIDLSLPLFLAVT
NIICLICFNTSYKNGDPALEIIKNYNDGILDTLGRDHMIDIFPGLKIFPNKTLEKMRN
CVKMRDDLLNEILEKYKQEKFSSDSITNMLDILIQARMNSDDNNAGSDRDSKLLSDKH
ILISIGDIFGAGVETTTSVVKWTVAFLLHNPQLQKKIQEEIDQNVGFGRIPTMSDRSK
LILLEATIREVLRIRPAAPMLIPHKAIVDSSIGEFAVDKGTSVIINLWALHHNEKEWY
RPDQFMPERFLDATKSQLISPSLSYLPFGAGPRSCVGEILARQELFLVMAWLLQRFDL
EAPDDGQLPSLEGIPRVVFLIESFKVKIKVRQAWREAQAEGST
CYP17 rat
PIR A31359 (507 amino acids)
Namiki, M., Kitamura, M., Buczko, E. and Dufau, M.L.
Rat testis P-450-17-alpha cDNA: the deduced amino acid
sequence, expression and secondary structural configuration.
Biochem. Biophys. Res. Commun. 157, 705-712 (1988)
CYP17 rat
PIR D41425 (16 amino acids)
Imaoka, S., Kamataki, T. and Funae, Y.
Purification and characterization of six cytochromes P-450
from hepatic microsomes of immature female rats.
J. Biochem. 102, 843-851 (1987)
CYP17 rat
GenEMBL S50146 Z11902 (3345bp)
PIR S20655 (97 amino acids)
Nason,T.F., Han,X.G. and Hall,P.F.
Cyclic AMP regulates expression of the rat gene for steroid
17 alpha-hydroxylase/C17-20 lyase P-450 (CYP17) in rat Leydig
cells.
Biochim. Biophys Acta 1171, 73-80 (1992)
Note: have not been able to download S50146 from GCG or NCBI.
CYP17 rat
GenEMBL X69816 (7556bp)
Givens,C.R., Zhang,P., Bair,S.R. and Mellon,S.H.
Transcriptional regulation of rat cytochrome P450c17 expression in
mouse Leydig MA-10 and adrenal Y-1 cells: identification of a
single protein that mediates both basal and cAMP-induced activities.
DNA Cell Biol. 13, 1087-1098 (1994)
CYP17 rat
PIR S24316 (97 amino acids)
Zhang, P., Nason, T.F., Han, X.G. and Hall, P.F.
Gene for 17-alpha-hydroxylase/C(17-20) lyase P-450: complete
nucleotide sequence of the porcine gene and 5' upstream
sequence of the rat gene.
Biochim. Biophys. Acta 1131, 345-348 (1992)
Cyp17 mouse
genEMBL M64863 AC079419.1 Mm.1262
MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLP
RRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTL
GLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYD
GESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFP
WLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNN
TGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQY
VGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVI
INLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQE
LFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST
CYP17 hamster
no accession number
Cloutier,M., Fleury,A., Courtemanche,J., Ducharme,L.
Mason,J.I. and Lehoux,J.G.
Cloning and expression of hamster adrenal cytochrome P450c17 cDNA.
Ann. N.Y. Acad. Sci. 774, 294-296 (1995)
CYP17 Cavia (guinea pig)
GenEMBL S75277(1732bp)
Tremblay,Y., Fleury,A., Beaudoin,C., Vallee,M. and Belanger,A.
Molecular cloning and expression of guinea pig cytochrome P450c17
cDNA (steroid 17 alpha-hydroxylase/17,20 lyase): tissue
distribution, regulation, and substrate specificity of the
expressed enzyme.
DNA Cell Biol. 13 (12), 1199-1212 (1994)
CYP17 Cavia porcellus (guinea pig)
PIR S52756 (508 amino acids)
Huang,Y., Voigt,J.M. and Colby,H.D.
unpublished
CYP17 pig
GenEMBL Z11854 to Z11856 GenEMBL S40341 (1858bp)
PIR S24233 (501 amino acids) PIR S30074 (501 amino acids)
Zhang,P. Nason,T.F., Han,X.G. and Hall,P.F.
Gene for 17 alpha-hydroxylasae/C(17-20) lyase P-450: complete
nucleotide sequence of the porcine gene and 5' upstream sequence of
the rat gene.
Biochim. Biophys. Acta 1131, 345-348 (1992)
CYP17A1 Capra hircus (goat)
AF251387
MWVLLGVFLLTLAYLFWPKTKHSAAKYPRSLPSLPLVGSLLFLP
RRGQQHENFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAREVLLKKGKEFSGRPKVATL
DILSDNQKGIAFADHGAHWQLHRKLVLNAFALFKDGNLKLEKIINQEANVLCDFLATQ
HGQSIDLSEPLSLAVTNIISFICFNFSFKNEDPALKAIQNVNDGILEVLSKEILLDIF
PALKIFPSKAMEKMKGCVETRNELLNEILEKCQENFTSDSITNLLHILMQAKVNADNN
NAGPDQDSKLLSNRHMLATIADIFGAGVETTTSVIKWIVAYLLHHPSLKKRIQDSIDQ
NIGFNRTPTISDRNCLVLLEATIREVLRIRPVAPMLIPHKAIIDSSIGDLTIDKGTDV
VVNLWALHHNEKEWQQPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQ
ELFLFMSRLLQRFNLEIPDDGKLPSLEGNPSLVLQIKPFKVKIEVRQAWKEAQAEGSTS
CYP17 Sus scrofa (pig)
GenEMBL U41519 to U41525
Conley,A.J., Graham-Lorence,S.E., Kagimoto,M., Lorence,M.C.,
Murry,B.A., Oka,K., Sanders,D. and Mason,J.I.
Nucleotide sequence of a cDNA encoding porcine testis 17
alpha-hydroxylase cytochrome P-450.
Biochim. Biophys. Acta 1130, 75-77 (1992)
MWVLLVFFLLTLTYLFWPKTKGSGAKYPRSLPVLPVVGSLPFLP
RRGHQHMNFFKLQDKYGPIFSFRLGSKTTVVIGDHQLAKEVLLKKGKEFSGRPRVMTL
DILSDNQKGIAFADHGTSWQLHRKLALSTFSLFKGGNLKLENIINQEIKVLCDFLATR
NGESIDLAQPLSLAMTNIVSFICFNFSFKKGDPALQAIVNFNDGILDAVGKEILYDMF
PGIRILPSQTLENMKQCVRMRNELLREILENRKENYSRNSITNLLDIMIQAKTNAESN
TGGPDHNLKLLSDRHMLATVADIFGAGVETSASVVKWIVAFLLHYPLLRKKIQDAIDQ
NIGFNRAPSISDRNQLVLLEATIREVLRFRPVSPTLIPHRAIIDSSIGEFTIDKDTDV
VVNLWALHHNEKEWHRPDLFMPERFLDPTGTQLISPSLSYLPFGAGPRSCVGEMLARQ
ELFLFTAGLLQRFDLELPDDGQLPCLVGNPSLVLQIDPFKVKIKERQAWKEAHTEGSTS
CYP17 bovine
GenEMBL M64646 (1725bp)
Zuber,M.X., John,M.E., Okamura,T., Simpson,E.R. and Waterman,M.R.
Bovine adrenocortical cytochrome P-450-17-alpha: Regulation of gene
expression by ACTH and elucidation of primary sequence
J. Biol. Chem. 261, 2475-2482 (1986)
CYP17A1 Bos taurus (cow)
See cattle page for details
MWLLLAVFLLTLAYLFWPKTKHS
116 GAKYPRSLPSLPLVGSLPFLPRRGQQHKNFFKLQEKYGPIYSFRLGSKTTVMIGHHQLAR 295
296 EVLLKKGKEFSGRPKVATLDILSDNQKGIAFADHGAHWQLHRKLALNAFALFKDG 460
461 NLKLEKIINQEANVLCDFLATQHGEAIDLSEPLSLAVTNIISFICFNFSFKNEDP 625
626 ALKAIQNVNDGILEVLSKEVLLDIFPVLKIFPSKAMEKMKGCVQTRNELLNEILEKCQEN 805
806 FSSDSITNLLHILIQAKVNADNNNAGPDQDSKLLSNRHMLATIGDIFGAGVETTTSVIK 982
983 WIVAYLLHHPSLKKRIQDDIDQIIGFNRTPTISDRNRLVLLEATIREVLRIRPVAPTLIP 1162
1163 HKAVIDSSIGDLTIDKGTDVVVNLWALHHSEKEWQHPDLFMPERFLDPTGTQLISPSL 1336
1337 SYLPFGAGPRSCVGEMLARQELFLFMSRLLQRFNLEIP 1450
DDGKLPSLEGHASLVLQIKPFKVKIEVRQAWKEAQAEGSTP*
CYP17 Ovis aries (sheep)
GenEMBL L40335 (1728bp)
Murry,B.A., Swart,P. and Mason,J.I.
Cloning and expression of ovine cytochrome P-450 17-alpha
hydroxylase/c17-20 lyase.
Unpublished (1995)
CYP17 Equus caballus (horse)
GenEMBL D30688(1906bp) D13818
Hasegawa,T., Mukoyama,H., Yoshida,S. and Takahashi,M.
Molecular cloning and nucleotide sequence of equine testicular
cytochrome P-450 steroid 17alpha-hydroxylase/C17,20-lyase messenger
ribonucleic acid.
Biol. Reprod. Mono. 1, 615-622 (1995)
CYP17 Equus caballus (horse)
GenEMBL D88184(6217bp)
Hasegawa,T.
Exon/Intron structure of Equine P450c17.
unpublished (1996)
CYP17A1 Gallus gallus (chicken)
NM_001001901
MPPLAVLLLALALLCAWRLSYSQGPTGTGTGRPRSLPALPLVGS
LLQLAGHPQLHLRLWRLQGRYGSLYGLWMGSHYVVVVNSYQHAREVLLKKGKAFAGRP
RTVTTDLLSRGGKDIAFASYGPLWKFQRKLVHAALSMFGEGSVALEKIICREAASLCE
TLGAAQDMALDMAPELTRAVTNVVCSLCFNSSYRRGDPEFEAMLEYSQGIVDTVAKES
LVDIFPWLQIFPNRDLALLKRCLKVRDQLLQQKFTEHKEAFCGDTVRDLMDALLQVRL
NAENNSPLEPGLELTDDHLLMTVGDIFGAGVETTTTVLKWAVLYLLHYPEVQKKIQEE
MDQKIGLARHPHLSDRPLLPYLEATISEGLRIRPVSPLLIPHVSLADTSIGEYSIPKG
ARVVINLWSVHHDEKEWDKPEEFNPGRFLDEQGQHIHSPSPSYLPFGAGIRVCLGEVL
AKMELFLFLAWVLQRFTLECPQDQPLPSLEGKFGVVLQVQKFRVKARLREAWRGEMVR
CYP17A1 Coturnix japonica (Japanese quail)
AB281617
CSLCFNSSYRRGDPEFEAMLEYSQGIVDTVAKESLVDIFPWLQI
FPNKDLALLKRCLKVRDQLLQQKFNEHKEAFSGDTVRDLMDALLQVRLNAENNSPEPG
LELTDDHLLMTVGDIFGAGVETTTTVLKWAVLYLLHYPEVQKKIQEEMDQKIGLARHP
HLSDRPLLPYLEATISEVLRIRPVSPLLIPHVSLADTSIGEYSIPKGARVVINLWSVH
HDEKEWDKPEEFNPGRFLDEQGQHIHSPSPSYLPFGAGIRVCLGEVLAKMELFLFLAW
VLQRFTLECPQDQPLPSLEGKFGVVLQVQKFRVKARLREAWRGEMVR
CYP17A1 Alligator mississippiensis (American alligator)
DQ007997
PNKDLAWLRQCVKARDELLQKKFTEHKEAFCSDSVSDLMDALLR
AKLNMENNNSRLEPGLELTDDHLLMTVGDIFGAGVETTTTALKWAIIYMLHYPEVQRK
IQEELDQQLGLERRPQLSDRQRLPYLEATISEVLRIRPVAPLLIPHVALVDSSIGDYV
IPKGTHVIVNIWAIHHDQDEWDKPEEFNPGRFLDEKGQRIYSPTPSYM
CYP17A1 Xenopus tropicalis
CX931022 DR883840.1 CX957932.1
50% to CYP17A1 human
MISYVAAAVLLAFGLALLSIWKFAGGKPRGAKYPNSLPCLPFIGSLLHLASHLAPHI
LFNKLQEKYGSLYSFKMGSHYIVIVNHHEHAKEVLLKKGKTFGGRPRAVTTDLLTRNAKD
IAFADYSPTWKFHRKLVHAALSMFGEGTVAIEKIISREAASLCQTLITFQGSPLDMAPEL
TRAVTNVVCALCFNARY
KRCDPEFEEMLAYSKGIVDTVAKDSLVDIFPWLQIFPNKDLEILKRSVAIRDKLLQKKLK
EHKEAFCGEEVNDLLDALLKAKLSMENNNSNISQEVGLTDDHLLMTVGDIFGAGVETTTT
VLKWAVAYLLHYPKVQAKIQEELDVKVGFGRHPVLSDRRILPYLDATISEVLRIRPVAPL
LIPHVALHESSIGEYTIPQDARVVINLWSLHHDPNEWXNPEEFIPDRFLDENGNHLYTPS
QSYLPFGAGIRVCLGEALAKMEIFLFLSWILQRFTLEVPAGDSLPDLDGKFGVVLQVKKFRVT
AKLREVWKNIDLTT*
CYP17 Xenopus laevis (African clawed frog)
AF325435 AW639059 bl78a09.w1 AW634003 bl14g07.w1 AW638539 bl71c05.w1
AW639868 bl88e07.w1 AW640378 bl94e08.w1 AW640811 bl99b10.w1
BE131888 db39e04.y1 BE131756 db35g03.y1 BG363813 dc94b02.y1
BE027018 db35h02.x1 BF048873 db80d06.y1 BE027013 db35g03.x11871
SwissProt Q9DDJ5, Q5BL89
MISYVAGALLLAFGLALISVWKFAGGKHRGAKYPNSLPCLPFIG
SLLHIGNHLPPHILFCKLQEKYGSLYSFRMGSHYIVIVNHHEHAKEVLLKKGKTFGGR
PRAVTTDILTRNAKDIAFANYSPSWKFHRKVVHAALSMFGEGTVAIEKIISREATSLC
QSLISFQDNPLDMAPELTRAVTNVVCALCFNTRYKRCDPEFEEMLAYSKGIVDTVAKD
SLVDIFPWLQIFPNKDLDILKRSVAIRDKLLQKKLKEHKEAFCNEEVNDLLDALLKAK
LSMENNNSNISQEVGLTDDHLLMTVGDIFVAGVETTTTVLKWTMAYLLHYPEVQTKIQ
EELDFKVGFGRHPVLSDRRILPYLDATISEVLRIRPVAPLLIPHVALQESSIAEYTIP
QDARVVINLWSLHHDPNEWENPEEFNPERFLDENGNHVYSPSQSYLPFGAGIRVCLGE
ALAKMEVFLFLSWILQRFTLELPAGDSLPDLDGKFGVVLQVKKFRVTTKLREAWKNID
LTT
CYP17A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP17A1 Fugu rubripes (pufferfish)
LPC12298.x1 Scaffold_2373
Scaffold_4175
80% to Oryzias latipes 17, 79% to trout 17 73% to catfish
61% to dogfish 48% to other CYP17 from Fugu
MDWVLFVYAFSAVNLALLALHLKFRTPASGPRGPPRLPALPLIGSLLSLRSPHPPHVLFKE
LQGKYGQTYSLMMGSHRVIIVNHHAHAKEVLLKKGKIFAGRPRS 11667 (0)
11572 VTTDVLSRDGKDIAFGDYSATWRFHRKIVHGALCMFGEGSASIEKI 11435 (1)
10871 ICAEAASLCSILSEAWTAGLALDLSPELTRAVTNVICSLCFSSSYRRGDAEFEAMLHYSQ 10692
10691 GIVDTVAKDSLVDIFPCLQ 10635 (0)
IFPNADLRLLKRCVSVRDKLLQKEYDKHK (0)
AAYSDHVQRDLLDALLRAKCSAENNNTTGINAESVGLTDDHLLMT
VGDIFGAGVETTTTVMKWAITYLIHHPQ 9765 (0)
9637 IQSRIQEELDSRVGMDRSPQLSDRGSLPYLEATIREVLRIRPVAPLFIPHVALSDT 9473 (2)
9369 SIGDFAVKKGTRVVINLWSLHHDEKEWENPERFDP 9265 (1)
GRFLNSEGTGLVIPSSSYLPFGAGVRVCLGEALAK 8558
8557 MELFLFLSWILQRFTLTVPSGHSLPSLEGKFGVVLQPTKYKVNATPRPGWEGKCKACWN* 8378
CYP17A1 Tetraodon nigroviridis (Green puffer)
lower case is from fugu,
~91% to fugu CYP17A1
MDWVLGLYVFSALSLALLALQLTVRTPASGPNGPPSLPALPLIGSLLSLRSPHPPHVLFK
ELQGKYGQTYSLMMGSHCVIIVNHHIHAKEVLLKKGKIFAGRSRS (0)
VTTDVLSRDGKDIAFGDYSATWRFHRKIVHGALCMFGEGSASIEKI (1)
ICAEATSLCSVLSEACAAGLALDLSPELTRAVTNVICSLCFSSSY
rrgdaefeamlhysqgivdtvakdslvdifpclq (0)
IFPNADLRLLKQCVSVRDKLLQKQYDKHK (0)
AAYSDHVQRDLLDALLRAKCSAENNNTAEINAESVGLTDDHLLMTVGDIFGAGVE
TTTTVMKWAITYLIHYPQ (0)
IQSRIQEELDSRVGMDRSPKLSDRGSLPYLEATIREVLRIRPVAPLFIPHVALSDTS (2)
IGDFTVKRGTRVIINLWSLHHDEKEWEnperfdp (1)
grflnsegtglvipsssylpfgagvrvclgealak
melflflswilqrftltvpsghslpslegkfgvvlqptkykvnatprpgwegkckacwn*
CYP17A1-de6b7b8b Tetraodon nigroviridis (Green puffer)
downstream of CYP17A1
LRIRPVAPLFIPHVALSDTS (2)
IGDFTVKRGTRVIINLWSLHHDEKEWENPELFDP (1)
GRFLNSEGTGLVIPSSSYLPFGAGVRVCLGEALAKMELFLFLSWILQRFTLTVPP*Y
SLPSLEGKFGVVLLPVLYNVNATPRSGWEKNAHVF*
CYP17 Oncorhynchus mykiss (rainbow trout)
GenEMBL S50356
Sakai,N., Tanaka,M., Adachi,S., Miller,W.L. and Nagahama,Y.
Rainbow trout cytochrome P-450c17 (17 alpha-hydroxylase/17-20
lyase) cDNA cloning, enzymatic properties and temporal pattern of
ovarian P-450c17 mRNA expression during oogenesis.
FEBS Lett. 301, 60-64 (1992)
Identical to X65800
CYP17 Oncorhynchus mykiss (rainbow trout)
GenEMBL X65800 (2287bp) Swiss P30437 (514 amino acids)
Sakai,N., Tanaka,M., Adachi,S., Miller,W.L. and Nagahama,Y.
Rainbow trout cytochrome P-450c17 (17
alpha-hydroxylase/17,20-lyase). cDNA cloning, enzymatic properties
and temporal pattern of ovarian P-450c17 mRNA expression during
oogenesis
FEBS Lett. 301, 60-64 (1992)
Identical to S50356
CYP17 Oryzias latipes (medaka)
GenEMBL D87121(2421bp)
Kobayashi,D., Matsuyama,M., Tanaka,M., Fukada,S. and Nagahama,Y.
Structural analysis of medaka P-450c17 and expression in the
ovarian follicle.
unpublished (1996)
CYP17 Oryzias latipes (medaka)
GenEMBL D87122(2302bp)
Kobayashi,D., Tanaka,M., Fukada,S. and Nagahama,Y.
Presence of a Novel Cytochrome P-450c17 Transcripts in Medaka
Gonads
unpublished (1996)
note: this sequence is missing exon 6
otherwise identical to D87121
CYP17 Squalus acanthias (dogfish)
GenEMBL S77384 (1964bp)
Trant,J.
Isolation and characterization of the cDNA encoding the spiny
dogfish shark
(Squalus acanthias) form of cytochrome P450c17
J. Exp. Zool. 272, 25-33 (1995)
CYP17 Ictalurus punctatus (channel catfish)
GenEMBL AF063837
Trant,J.M., Berard,C., Byrne,B.J. and Wunder,J.
Isolation and heterologous expression of the cDNA encoding the
cytochrome P450 17-hydroxylase from the channel catfish (Ictalurus
punctatus)
Unpublished (1998)
CYP17A2 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP17A2 Fugu rubripes (pufferfish)
No accession number
Scaffold_8086
50% to Oryzias latipes 17, 48% to trout 17 50% to catfish
49% to dogfish 48% to other CYP17 from Fugu
1198 MVTVGSFLIFRRPVRGSEPGSEAGPPRVKVPCISWVPVLGSLPWLRGGRPLHLIFTQLSYR 1380 (2)
1600 YGPLFALYLGPHLTVVVNNHQHAREVLLLRGKDFAGRPRM 1719 (0)
1797 VTTDLLTRGGKDIAFSDYCPLWKSHRRLVQNSFTLFGEGTSRLQDM 1934 (1)
2061 VLAAVDSLCEELLSMEGRGFDPAPAVTRAVTNVVCMLVFSATYRHGDSELQEVLRYNDGI 2240
2241 VQTIAGGGLVDIYPWMK 2291 (0)
2372 VFPNKTLSKLKACIAVRDRLLTHKLEEHK 2458 (0)
2622 ATLTDNQPRDLLDALLMGQVGRGRRKGSGRVEEDIITEDHVLMTAAEAFGAGVETTSTTLLWILAYLLHHPQ 2837 (0)
2925 VQERVQKELDDHVGSERPVRVSDRARLTYLDCVINEGMRIRPVSPVLIPHTAMTDSR 3074 (2)
3870 IGGHHISRGTRVLVNMWSIHHDSAHWDKPDLFNP 3971 (1)
4519 DRFRDHQGQRVTPSCFLPFGAGPRVCVGESLARLELFLFLSSLLQRMSFRLPNGA 4692
4693 SPPDLQGRMGVVLQPVPYKVVVTPRVG* 4776
CYP17 fragment a Fugu rubripes (pufferfish)
No accession number
Fc:c028I22x2 LPC.10549.x2 Length = 1007 61% to 17A1 Fugu
GAPRATTDNHHAHAKEARPKKGKKAAGRPRK exon 1
ATTDGASRDGTDTAEGDHSATRRDQR exon 2
CYP17 fragment b Fugu rubripes (pufferfish)
No accession number
Fc:c028I22x1 LPC.10549.x1 Length = 894
78% to Fc:c028I22x2 65% to 17A1 Fugu
KEQQAEHGQTTSRMMGSHRGNTDNQHAHAKEARQKKGKKGAGRPRK exon 1
ATTDGRSRDGTDIAEGDHSATWRHHRKIVQRARRRNGEGSAPSEKI exon 2 C-helix
Note: CYP17A2.1, .2 and .3 could be assmbled into a complete sequence
84% to CYP17A2 fugu
CYP17A2.1 Tetraodon nigroviridis (Green puffer)
84% to CYP17A2 N-term, lower case is fugu seq.
MLARLLSALDAFFSHSSLLSLLPSPSPSLLLVVSVA
VVVGSFLRFGRTVQGSGPAGGSGPAAGPVPCLPRLPLLGSLPWLRGAPPPHLLFTQLSCR (2)
YGPLFSFYLGPHLTLVVNQHQHAREVLQLRGKDFAGRPRM (0)
VTTELLTRGGKDIAFSDYCPLWRAHRRLVHHSFTLFGEGTRGLQEM (1)
vlaavdslceellsmegrgfdpapavtravtnvvcmlvfsatyrhgdselqevlryndgi 2240
vqtiaggglvdiypwmk (0)
CYP17A2.2 Tetraodon nigroviridis (Green puffer)
.1 and .2 are 473 kb apart, 82% to CYP17A2, I-helix to K-helix
lower case is fugu seq.
VFPNETLRRLKSCIAVRDRLLTRKLEEHK (0)
ATLGDGQPRDLLDALLMGQVDRGRSQESEGLEDETITDDHVLMTAAEAFGAGVETTSTT
LLWILAYLLHHPR (0)
VQEQVQKELDEHVGRERLVRLSDRAKLTYLDCVINEGMRICPVSPVLIPhtamtdsr (2)
CYP17A2.3 Tetraodon nigroviridis (Green puffer)
C-term, lower case is fugu seq. 88% to CYP17A2 fugu
igghhisRGTRVLVNMWSIHHDPERWDKPDLFNP (1)
DRFRDPQGQRLTPSYFMPFGAGPRVCVGESLARLEIFLFLSSLLQRMSFRLPDGASP
PDLQGRLGVVLQPLPYQVVVTPRRGWGPTEAPECQSFHKGGE*
CYP17A2.4P Tetraodon nigroviridis (Green puffer)
aa 104-224 pseudogene fragment around C-helix to mid
TELLTRGGKDIAFSDYCPL & WRAHR &
LVHHSCSLFGEGTRGLQDM (1)
LPVVHALCEELLSSGGRGLDPSPAVTR &
AVTNVVCMLVFGASYRRGDSELQEVLQYNDGIVQTIAAGGLVDIYPWMK
18A Subfamily
Cyp18a1 Drosophila melanogaster
GenEMBL S66112 (63bp)
Hurban,P. and Thummel,C.
Isolation and characterization of fifteen ecdysone-inducible
drosophila genes reveal unexpected complexities in ecdysone regulation.
Molec. Cell Biol. 13, 7101-7111 (1993)
Note: very short ecdysone inducible fragment in the heme binding
region about 2/3 of amino acids are identical to 2D sequences.
called Eig 17-1
dimethylnitrosamine demethylase
Cyp18a1 Drosophila melanogaster
GenEMBL U44753(2539bp)
Bassett,M.H, Waterman,M.R., McCarthy,J.L. and Sliter,T.J.
Cloning and characterization of CYP18 in Drosophila melanogaster:
identification of an insect member of a new cytochrome P450 family.
unpublished (1996)
complete sequence from the Eig 17-1 fragment
Cyp18a1 Drosophila melanogaster
GenEMBL AC012164 114600-117669 also AC015216
Cyp18a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP18A1 Spodoptera littoralis (cotton leafworm)
No accession number
Lyndsay Davies
Submitted to nomenclature committee 2/22/02
61% identical to CYP18 from Drosophila
since there is only one CYP18 seq in Drosophila this new sequence
will be called CYP18 without a subfamily or number like CYP18A1.
If more CYP18s are found in a single species this may have to change.
CYP18A1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
99% to CYP18A1 Spodoptera littoralis AM086639, 2 aa diffs
CYP18A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
84% to CYP18A1 Spodoptera littoralis
CYP18A1 Plutella xylostella
Gene number CCG012412.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
87% to CYP18A1 Spodoptera littoralis AM086639
CYP18A1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP18A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup13.1a
60% to 18A1 Drosophila melanogaster.
CYP18A1 Linepithema humile (argentine ant)
No accession number
CYP18A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
60% to CYP18A1 Apis mellifera
CYP18A1 Solenopsis invicta (fire ant)
See Solenopsis page
58% to CYP18A1 Apis mellifera
CYP18A1 Pogonomyrmex barbatus (seed-harvester ant)
No accession number
Reed Johnson
Submitted to nomenclature committee June 3, 2010
51% to CYP18A1 Apis mellifera
CYP18A1 Bombyx mori (silkworm)
AU005208 EST BAAB01190855.1 BAAB01187772.1
60% to CYP18A1 Drosophila
See silkworm page for sequence
CYP18A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_968393
58% to 18A1 Drosophila melanogaster
MFVYSGLVLWNFLAEELSTKVLAVFLMVLFLVRLVQMLVQMLKEASALPPGPWGLPILGSLPFLKGDLHL
HFRDLTHKYGSLISTRLGSQLIVVLSDYKMIRDAFRKEEFTGRPITEFTTLLDGYGVINTAGKLWKDQRR
FLHDGLRHFGMSYIGSRKTQMENRIMREVEEFLSVLTARKDTPIDLNPVLAVSLSNVICDILMSVRFSHN
DERFKRFMFLIDEGFKLFSSLEASFFIPILKYLPGQRQTREKIAKNRAEMAQFLQETIEEHRKSFDPSHL
RDLLDTYLYEIQKADEEGTGDHLFEGKDHDRQMQQIMGDLFSAGMETIKSSLQWAVLFMLHHPEVMKAVQ
EELDQVVGRRRLPKLEDLPYLPVTESTMLEVLRISSIVPMGTTHAPTRDLKLNGFHLPRHAQIVPLLHSV
HMDPSLWHEPERFNPSRFINAEGKVVKPEYFLPFGVGRRMCLGEILARMEIFSFFSSLLHSFDICVPTGE
TLPSLKGVAGVTISPNAFRVCLKPRPMEWDSMGTIRPAGSH
CYP18A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010 revised Nov. 22 2011
CYP2 clan
Clone name seq 44
61% to CYP18A1 Tribolium castaneum
complete sequence
CYP18A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
76% to CYP18A1 Tribolium castaneum
CYP18A1 Aedes aegypti (yellow fever mosquito)
CYP18A1 Culex pipiens
CPIJ001038
CYP18A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph18, 56% to 18A1 Apis
Pediculus genome site
CYP18A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP18A1 Laodephgax striatellus (small brown planthopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee June 22, 2011
Clone name scaffold30421
77% to CYP18A1 Pediculus humanus
note: species corrected from Sogatella frucifera
(white-backed plant hopper)
CYP18A1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 6, 2011
Complete seq. 65% to CYP18A1 Pediculus humanus
CYP18A1 Daphnia pulex (water flea)
CYP18A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig12849 282aa
58% TO CYP18A1, in the CYP2 clan
CYP18A1 Trialeurodes vaporariourum (whitefly)
CYP18A1 Acyrthosiphon pisum (pea aphid)
LOC100163652
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
26 hydroxylase (not a Halloween gene)
CYP2 clan
MTAETMSDGDGYSRELWLNAVAAALGLTYSAYRQLRAARTLPPGPWGVPFLGYAPFLSNHCTYLKYNELARRYGPICSFTQRGNTVILLSDHKLIKTAFDMKQITGRPNDGYMDIIGGYGAVNSTGKLWESQRKFLHLVLRHMGMTFTGHNRLNMENRIMIEVSTLTETFHKTCGKPIDLNAGSLCLAITNVISSLTMSVRFEPNDPRFERYMHMVDEGFKLFGMLRPVSLFLPRRHITDERNIQEKIKNNHQEIAKYFQSIIEEHRSTFDPNSIRDLVDAYLLEIKRSQEAGTMDQLFQGLDPNRQVQQILGDLFSAGMETIKNTILWAMVYMLHYPDVMTKVQDEIDSVVGQYKSPVLDDYPNLPYTQATLYEVLRKSSITPLGTTHATTSDVTLNGYHIPTGAQIIPLQHFVHNDPNLWDEPEAFKPERFINAEGKVKKPDCFLPFGVGRRKCLGETLAQMELYLFFSTLLHEFDVCLPDGDELPSMDGQVGITLTPQSFKVVMKARNK*
CYP18A1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
3 disconnected pieces 58-59% to CYP18A1 Apis or Nasonia
CYP18B1 Bombyx mori (silkworm)
BAAB01081335.1 BAAB01007952.1
BAAB01142048.1 BAAB01138082.1 BAAB01045663.1
39% to CYP18A1 Bombyx
See silkworm page for sequence
CYP18B1 Plutella xylostella
Gene number CCG012411.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
53% to CYP18B1 Bombyx mori
CYP18B2 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP18B3 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
56% to CYP18B1 Bombyx mori
CYP18C1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
19A Subfamily
CYP19 human
GenEMBL S52034 (142bp) S52789 (106bp) S52793 (149bp)
S52794 (125bp)
Harada,N.
A unique aromatase (P-450AROM) mRNA formed by alternative
use of tissue-specific exons 1 in human skin fibroblasts.
Biochem. Biophys. Res. Commun. 189, 1001-1007 (1992)
CYP19 human
GenEMBL D14473 (295bp) S59092 S59095 S59171
Toda,K and Shizuta,Y.
Molecular cloning of a cDNA showing alternative splicing of
the 5'-untranslated sequence of mRNA for human aromatase P-450.
Eur. J. Biochem. 213, 383-389 (1993)
CYP19 human
GenEMBL D13391 (2238bp)
Katsumi,T. and Shizuta,Y.
Identification and characterization of cis-acting regulatory
elements for
the expression of the human aromatase cytochrome P-450 gene.
J. Biol. Chem. 269, 8099-8107 (1994)
CYP19 human
GenEMBL D21240 (794bp) D21241 (3231bp)
Harada,N., Utsumi,T. and Takagi,Y.
Tissue-specific expression of the human aromatase cytochrome P-450
gene by alternative use of multiple exons 1 and promoters, and
switching of tissue-specific exons 1 in carcinogenesis.
Proc. Natl. Acad. Sci. U.S.A. 90 (23), 11312-11316 (1993)
CYP19 human
GenEMBL X55983 (669bp)
Toda,K., Miyahara,K., Kawamoto,T., Ikeda,H., Sagara,Y. and
Shizuta,Y.
Characterization of a cis-acting regulatory element involved in
human-
aromatase P-450 gene expression.
Eur, J. Biochem. 205, 303-309 (1992)
exon 1
CYP19 human
GenEMBL S71536 (792bp)
Toda,K., Simpson,E.R., Mendelson,C.R., Shizuta,Y. and Kilgore,M.W.
Expression of the gene encoding aromatase cytochrome P450 (CYP19)
in fetal tissues
Mol. Endocrinol. 8, 210-217 (1994)
CYP19 human
GenEMBL M32245 (840bp)
Harada,N., Yamada,K., Saito,K., Kibe,N., Dohmae,S. and Takagi,Y.
Structural characterization of the human estrogen synthetase
(aromatase) gene.
Biochem. Biophys. Res. Commun. 166, 365-372 (1990)
CYP19 human
GenEMBL D29757 (875bp) PIR PC2041 (45 amino acids)
Honda,S.-I., Harada,N. and Takagi,Y.
Novel exon 1 of the aromatase gene specific for aromatase
transcripts
in human brain.
Biochem. Biophys. Res. Commun. 198, 1153-1160 (1994)
CYP19 human
GenEMBL M22246 (2966bp)
Harada,N.
Cloning of a complete cDNA encoding human aromatase: immunochemical
identification and sequence analysis
Biochem. Biophys. Res. Commun. 156, 725-732 (1988)
CYP19 human
GenEMBL L21982 (1166bp)
Mahendroo,M.S., Mendelson,C.R. and Simpson,E.R.
Tissue-specific and hormonally-controlled alternative promoters
regulate aromatase cytochrome P450 gene expression in human adipose
tissue
J. Biol. Chem. 268, 19463-19470 (1993)
CYP19 human
GenEMBL S85356 (1384bp)
Means,G.D., Kilgore,M.W., Mahendroo,M.S., Mendelson,C.R. and
Simpson,E.R.
Tissue-specific promoters regulate aromatase cytochrome P450 gene
expression in human ovary and fetal tissues.
Mol. Endocrinol. 5, 2005-2013 (1991)
CYP19 human
GenEMBL S96437 (971bp)
Kilgore,M.W., Means,G.D., Mendelson,C.R. and Simpson,E.R.
Alternative promotion of aromatase P-450 expression in the human
placenta.
Mol. Cell. Endocrinol. 83, R9-R16 (1992)
CYP19 human
PIR A40542 (48 amino acids)
Mahendroo, M.S., Means, G.D., Mendelson, C.R. and Simpson, E.R.
Tissue-specific expression of human P-450-AROM. The promoter
responsible for expression in adipose tissue is different
from that utilized in placenta.
J. Biol. Chem. 266, 11276-11281 (1991)
CYP19A1 Pan troglodytes (chimpanzee)
XM_001169447.2
99% (2 aa diffs) to human
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGT SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSS MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRM VTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQ GYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAMEVLIAEKRRRISTEEKLEECM DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIK EIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAI LVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
CYP19A1 Macaca fascicularis (cynomolgus monkey)
AB071061
MVLEMLNPMHYNITSMVPEAMPAATMPILLLTGLFLLVWNYEGT
SSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNQVYGEFMRVWISGEETLIISKSSS
MFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPDLWKTTRPFFMKALSGPGLVRM
VTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNMLFLRIPLDESAIVVKIQ
GYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECM
DFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIMK
EIQTVVGERDVKIDDMQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAI
LVTLLRRFHVKTLQGQCVERIQKIHDLSSHPDETKNMLEMIFTPRNSDRCLEH
CYP19 Macaca fuscata (Japanese macaque)
GenEMBL S79807(369bp)
Yamada-Mouri,N., Hirata,S., Hayashi,M. and Kato,J.
Analysis of the expression and the first exon of aromatase mRNA in
monkey brain.
J. Steroid Biochem. Mol. Biol. 55 (1), 17-23 (1995)
CYP19 rat
GenEMBL S59505 (639bp)
Fitzpatrick,S.L. and Richards,J.S.
cis-acting elements of the rat aromatase promoter required for
adenosine 3',5'-monophosphate induction in ovarian granulosa cells
and constitutive expression in R2C Leydig cells.
Molec. Endocrinol. 7, 341-354 (1993)
Note: promoter
CYP19 rat
GenEMBL Z11815 (590bp)
Hickey,G.J., Krasnow,J.S., Beattie,W.G. and Richards,J.S.
Aromatase cytochrome P450 in rat ovarian granulosa cells before and
after luteinization: Adenosine 3',5'-monophosphate-dependent and
independent regulation. Cloning and sequencing of rat aromatase
cDNA and 5' genomic DNA
Mol. Endocrinol. 4, 3-12 (1990)
CYP19A1 Mesocricetus auratus (hamster)
Genpept AAK57023
1 AMPASAMPLL LIMGLLVLIW NCESTSSIPG PGYCLGIGPL ISHGRFLWMG IGNACNYYNK
61 MYGEFMRVWI SGEETLIISK SSSMFHVMKH SNYISRFGSK RGLQCIGMHE NGIIFNNNPD
121 LWKTIRPFFM KALTGPGLVR MVTVCKESIK QHLDRLDEVT DNSGSVDV
CYP19 Oryctolagus cuniculus (rabbit)
GenEMBL Z68271(1783bp)
Delarue,B., Mittre,H., Feral,C., Benhaim,A. and Leymarie,P.
Rapid sequencing of rabbit aromatase cDNA using RACE PCR without
cloning.
C. R. Acad. Sci. III, Sci. Vie 319, 663-670 (1996)
CYP19 Oryctolagus cuniculus (rabbit)
GenEMBL Z70302(1455bp)
Delarue,B., Mittre,H. and Leymarie,P.
Expression des transcrits codant pour l'aromatase de lapin dans
differents tissus.
unpublished (1996)
Cyp19 mouse
Swiss P28649 (503 amino acids) GenEMBL D00659 (2420bp)
Terashima,M., Toda,K., Kawamoto,T., Kuribayashi,I., Ogawa,Y.,
Maeda,T. and Shizuta,Y.
Isolation of a full-length cDNA encoding mouse aromatase P450
Arch. Biochem. Biophys. 285, 231-237 (1991)
MFLEMLNPMQYNVTIMVPETVTVSAMPLLLIMGLLLLIWNCESS
SSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKMYGEFMRVWISGEETLIISKSSS
MFHVMKHSHYISRFGSKRGLQCIGMHENGIIFNNNPSLWRTIRPFFMKALTGPGLVRM
VEVCVESIKQHLDRLGEVTDTSGYVDVLTLMRHIMLDTSNMLFLGIPLDESAIVKKIQ
GYFNAWQALLIKPNIFFKISWLYRKYERSVKDLKDEIAVLVEKKRHKVSTAEKLEDCM
DFATDLIFAERRGDLTKENVNQCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILK
EIHTVVGDRDIKIEDIQNLKVVENFINESMRYQPVVDLVMRRALEDDVIDGYPVKKGT
NIILNIGRMHRLEYFPKPNEFTLENFEKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVV
LVTLLRRFQVKTLQKRCIENIPKKNDLSLHPNEDRHLVEIIFSPRNSDKYLQQ
CYP19 pig
no accession number
Corbin, C.J., Khalil, M.W. and Conley, A.J.
Functional ovarian and placental isoforms od porcine aromatase.
Mol. Cell. Endocrinol. 113, 29-37 (1995)
CYP19 Sus scrofa (pig)
GenEMBL L15471 (454bp)
Ko,Y., Choi,I., Green,M.L., Simmen,F.A. and Simmen,R.C.
Transient expression of the cytochrome P450 aromatase gene in
elongating porcine blastocysts is correlated with uterine
insulin-like growth factor levels during peri-implantation
development.
Mol. Reprod. Dev. 37 (1), 1-11 (1994)
Note: This is only a fragment of 80 amino acids, including
helix K and the EXXR conserved sequence.
CYP19 Sus scrofa (pig)
GenEMBL U52141(1133bp)
Choi,I., Collante,W., Simmen,R.C.M. and Simmen,F.A.
Molecular cloning of multiple forms of cytochrome p450 aromatase
and their developmental expression in porcine blastocysts,
endometrium, and placenta.
Unpublished (1997)
CYP19 Sus scrofa (pig)
GenEMBL U52142(1584bp)
Choi,I., Collante,W., Simmen,R.C.M. and Simmen,F.A.
Molecular cloning of multiple forms of cytochrome p450 aromatase
and their developmental expression in porcine blastocysts,
endometrium, and placenta.
Unpublished (1997)
CYP19 Sus scrofa (pig)
GenEMBL U37309 (417bp)
Choi,I., Simmen,R.C. and Simmen,F.A.
Molecular cloning of cytochrome P450 aromatase complementary
deoxyribonucleic acid from periimplantation porcine and equine
blastocysts identifies multiple novel 5'-untranslated exons
expressed in embryos, endometrium, and placenta.
Endocrinology 137 (4), 1457-1467 (1996)
CYP19 Sus scrofa (pig)
GenEMBL U37311(2470bp)
Choi,I., Simmen,R.C. and Simmen,F.A.
Molecular cloning of cytochrome P450 aromatase complementary
deoxyribonucleic acid from periimplantation porcine and equine
blastocysts identifies multiple novel 5'-untranslated exons
expressed in embryos, endometrium, and placenta.
Endocrinology 137 (4), 1457-1467 (1996)
CYP19 Sus scrofa (pig)
GenEMBL U57510
Choi,I., Collante,W., Simmen,R.C.M., Troyer,D. and Simmen,F.A.
Molecular cloning and structural characterization of porcine
cytochrome p450 aromatase chromosomal genes: evidence for the
existence of multiple, closely related genes that encode
developmental and tissue-specific isoforms of aromatase.
unpublished (1997)
CYP19 Sus scrofa (pig)
GenEMBL U57517(287bp) U57518(287bp) U57519(358bp)
Choi,I., Collante,W., Simmen,R.C.M., Troyer,D. and Simmen,F.A.
Molecular cloning and structural characterization of porcine
cytochrome p450 aromatase chromosomal genes: evidence for the
existence of multiple, closely related genes that encode
developmental and tissue-specific isoforms of aromatase.
unpublished (1997)
CYP19 Sus scrofa (pig)
GenEMBL U57520(517bp) U57521(495bp)
Choi,I., Collante,W., Simmen,R.C.M., Troyer,D. and Simmen,F.A.
Molecular cloning and structural characterization of porcine
cytochrome p450 aromatase chromosomal genes: evidence for the
existence of multiple, closely related genes that encode
developmental and tissue-specific isoforms of aromatase.
unpublished (1997)
CYP19A1 Sus scrofa (pig)
NM_214429
MVLEMLNPMHYKVTSMVSEVVPFASIAVLLLTGFLLLVWNYKNT
SSIPGPGYFLGIGPLISYLRFLWMGIGSACNYYNKTYGEFIRVWIGGEETLIISKSSS
VFHVMKHSHYTSRFGSKPGLQFIGMHEKGIIFNNNPVLWKAVRTYFMKALSGPGLVRM
VTVCADSITKHLDKLEEVRNDLGYVDVLTLMRRIMLDTSNNLFLGIPLDEKAIVCKIQ
GYFDAWQALLLKPDIFFKIPWLYRKYEKSVKDLKEDMEILIEKKRRRIFTAEKLEDCM
DFATELILAEKRGELTKENVNQCILEMLIAAPDTMSVTVFFMLFLIAKHPQVEEELMK
EIQTVVGERDIRNDDMQKLEVVENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVT
LVILLRRFQVQTPQDRCVEKMQKKNDLSLHPDETSGLLEMIFIPRNSDKCFTK
CYP19A2 Sus scrofa (pig)
NM_214430
Choi,I., Troyer,D.L., Cornwell,D.L., Kirby-Dobbels,K.R.,
Collante,W.R. and Simmen,F.A.
Closely related genes encode developmental and tissue isoforms of
porcine cytochrome P450 aromatase
DNA Cell Biol. 16 (6), 769-777 (1997)
86% to CYP19A3 pig
MVLEMLNPMYYKITSMVSEVVPFASIAVLLLTGFLLLLWNYENT
SSIPSPGYFLGIGPLISHFRFLWMGIGSACNYYNEMYGEFMRVWIGGEETLIISKSSS
VFHVMKHSHYTSRFGSKPGLECIGMYEKGIIFNNDPALWKAVRTYFMKALSGPGLVRM
VTVCADSITKHLDKLEEVRNDLGYVDVLTLMRRIMLDTSNNLFLGIPLDEKAIVCKIQ
GYFDAWQALLLKPEFFFKFSWLYKKHKESVKDLKENMEILIEKKRCSIITAEKLEDCM
DFATELILAEKRGELTKENVNQCILEMLIAAPDTLSVTVFFMLFLIAKHPQVEEAIVK
EIQTVIGERDIRNDDMQKLKVVENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVT
LVILLRRFQVQTPQDRCVEKMQKKNDLSLHPDETSGLLEMIFIPRNSDKSLDH
CYP19A3 Sus scrofa (pig)
NM_214431
Choi,I., Troyer,D.L., Cornwell,D.L., Kirby-Dobbels,K.R.,
Collante,W.R. and Simmen,F.A.
Closely related genes encode developmental and tissue isoforms of
porcine cytochrome P450 aromatase
DNA Cell Biol. 16 (6), 769-777 (1997)
86% to CYP19A2 pig
MVLEMLNPMNISSMVSEAVLFGSIAILLLIGLLLWVWNYEDTSS
IPGPGYFLGIGPLISHFRFLWMGIGSACNYYNKMYGEFMRVWIGGEETLIISKSSSIF
HIMKHNHYTCRFGSKLGLECIGMHEKGIMFNNNPALWKAVRPFFTKALSGPGLVRMVT
VCADSITKHLDKLEEVRNDLGYVDVLTLMRRIMLDTSNNLFLGIPLDESALVHKVQGY
FDAWQALLLKPDIFFKISWLYRKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDSMDF
TTQLIFAEKRGELTKENVNQCVLEMMIAAPDTMSITVFFMLFLIANHPQVEEELMKEI
YTVVGERDIRNDDMQKLKVVENFIYESMRYQPVVDFVMRKALEDDVIDGYPVKKGTNI
ILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVILV
TLLRRFQVQTQQGQCVEKMQKKNDLSLHPHETSGLLEMIFIPRNSDKCLEH
CYP19A1 Capra hircus (goat)
AY148883
MLLEVLNPRHYNVTSMVSEVVPIASIAILLLTGFLLLVWNYEDT
SSIPGPSYFLGIGPLISHCRFLWMGIGSACNYYNKMYGEFMRVWVCGEETLIISKSSS
MFHVMKHSHYISRFGSKLGLQFIGMHEKGIIFNNNPALWKAVRPFFTKALSGPGLVRM
VTICADSITKHLDRLEEVCNDLGYVDVLTLMRRIMLDTSNILFLGIPLDESAIVVKIQ
GYFDAWQALLLKPDIFFKISWLCRKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDCI
DFATELIFAEKRGELTKENVNQCILEMLIAAPDTMSVSVFFMLFLIAKHPQVEEAMMR
EIQTVVGERDIRIDDMQKLKVVENFINESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNLGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVI
LVTLLRRFHVQTLQGRCVEKMQKKNDLSLHPDETSDRLEMIFIPRNSDKCLEC
CYP19A1 Ovis aries (sheep)
NM_001123000
MLLEVLNPRHYNVTSMVSEVVPIASIAILLLTGFLLLVWNYEDT
SSIPGPSYFLGIGPLISHCRFLWMGIGSACNYYNKMYGEFMRVWVCGEETLIISKSSS
MFHVMKHSHYISRFGSKLGLQFIGMHEKGIIFNNNPALWKAVRPFFTKALSGPGLVRM
VTICADSITKHLDRLEEVCNDLGYVDVLTLMRRIMLDTSNILFLGIPLDESAIVVKIQ
GYFDAWQALLLKPDIFFKISWLCRKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDCI
DFATELIFAEKRGELTKENVNQCILEMLIAAPDTMSVSVFFMLFLIAKHPQVEEAMMR
EIQTVVGERDIRIDDMQKLKVVENFINESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNLGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRACAGKYIAMVMMKVI
LVTLLRRFHVQTLQGRCVEKMQKKNDLSLHPDETSDRLEMIFIPRNSDKCLEC
CYP19 bovine
GenEMBL S66248 (2104bp)
Hinshelwood,M.M., Corbin,C.J., Tsang,P.C. and Simpson,E.R.
Isolation and characterization of a cDNA insert encoding bovine
aromatase
cytochrome P450.
Endocrinology 133, 1971-1977 (1993)
Note two amino acid differences with Z32741
CYP19 bovine
GenEMBL M64646 (1725bp)
Zuber,M.X., John,M.E., Okamura,T., Simpson,E.R. and Waterman,M.R.
Bovine adrenocortical cytochrome P-450-17-alpha: Regulation of gene
expression by ACTH and elucidation of primary sequence.
J. Biol. Chem. 261, 2475-2482 (1986)
CYP19 bovine
GenEMBL Z32741 (4226bp) PIR S44210 (503 amino acids)
Vanselow,J. and Furbass,R.
Aromatase cytochrome P450 gene and pseudogene
unpublished (1994)
CYP19 bovine
GenEMBL Z69241 to Z69250 (genomic sequences)
Furbass,R. and Vanselow,J.
unpublished (1996)
CYP19P bovine
GenEMBL Z32813 (1006bp)
Vanselow,J. and Furbass,R.
Aromatase cytochrome P450 gene and pseudogene
unpublished (1994)
CYP19A1 Bos taurus (cow)
See cattle page for details
MLLEVLNPRHYNVTSMVSEVVPIASIAILLLTGFLLLVWNYEDTSSIPGPSYFLGIGPLI
SHCRFLWMGIGSACNYYNKMYGEFMRVWVCGEETLIISKSSSMFHVMKHSHYISRFGSKL
GLQFIGMHEKGIIFNNNPALWKAVRPFFTKALSGPGLVRMVTICADSITKHLDRLEEVCN
DLGYVDVLTLMRRIMLDTSNMLFLGIPLDESAIVVKIQGYFDAWQALLLKPDIFFKISWLCRKYEKSV
927 KDLKDAMEILIEEKRHRISTAEKLEDSIDFATELIFAEKRGELTRENVNQC 1079
1080 ILEMLIAAPDTMSVSVFFMLFLIAKHPQVEEAIIREIQTVVGERDIRIDDMQKLKVVEN 1256
1257 FINESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNLGRMHRLEFFPKPNEFTLE 1430
1431 NFAKNVPYRYFQPFGFGPRACAGKYITMVMMKVVLVTLLRR 1553
FHVQTLQGRCVEKMQKKNDLSLHPDETRDRLEMIFTPRNSDKCLER*
CYP19 Equus caballus (horse)
GenEMBL U37313 (458bp)
Choi,I., Simmen,R.C. and Simmen,F.A.
Molecular cloning of cytochrome P450 aromatase complementary
deoxyribonucleic acid from periimplantation porcine and equine
blastocysts identifies multiple novel 5'-untranslated exons
expressed in embryos, endometrium, and placenta.
Endocrinology 137 (4), 1457-1467 (1996)
CYP19A1 Equus caballus (horse)
NM_001081805
MILEMLNPMHYNLTSMVPEVMPVATLPILLLTGFLFFVWNHEET
SSIPGPGYCMGIGPLISHLRFLWMGLGSACNYYNKMYGEFVRVWISGEETLVISKSSS
TFHIMKHDHYSSRFGSTFGLQYMGMHENGVIFNNNPAVWKALRPFFVKALSGPSLARM
VTVCVESVNNHLDRLDEVTNALGHVNVLTLMRRTMLDASNTLFLRIPLDEKNIVLKIQ
GYFDAWQALLIKPNIFFKISWLSRKHQKSIKELRDAVGILAEEKRHRIFTAEKLEDHV
DFATDLILAEKRGELTKENVNQCILEMMIAAPDTLSVTVFFMLCLIAQHPKVEEALMK
EIQTVLGERDLKNDDMQKLKVMENFINESMRYQPVVDIVMRKALEDDVIDGYPVKKGT
NIILNIGRMHKLEFFPKPNEFTLENFEKNVPYRYFQPFGFGPRSCAGKFIAMVMMKVM
LVSLLRRFHVKTLQGNCLENMQKTNDLALHPDESRSLPAMIFTPRNSEKCLEH
CYP19A1 Canis familiaris (dog)
NM_001008715.1
86% to CYP19A1 human (called family 17 in Genbank)
MLLEMLNPMHYNITSMMPEVMPVATMPILLLTGFLLLVWNYEDT
SSIPGPGYCMGIGPLISHCRFLWMGIGSACNYYNKMYGEFMRVWICGEETLIISKSSS
MFHIMKHSHYSSRFGSKLGLQCIGMHENGIIFNNNPTLWKAIRPFFTKALSGPGLVRM
VTVCVGSIITHLDRLEEVSNELGYVDVLTLMRRIMLDTSNILFLGIPLDESAIVVKIQ
GYFDAWQALLLKPDIFFKISWLYKKYEKSVKDLKDAMEILIEEKRHRISTAEKLEDHM
DFATELIFAEKRGDLTRENVNQCILEMLIAAPDTMSVSVFFMLFLIAKHPKVEESIMK
EIQAVVGERDIRIDDMQKLKVVENFIYESMRYQPVVNLVMRKALQDDIIDGYLVKKGT
NIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRSCAGKYIAMVMMKVV
LVTLLRRFHVQTLQGECIENMQKKYGLSLHPDETNNLLEMVFVPRNSEKCLER
CYP19A1 Lagenorhynchus acutus (Atlantic white-sided dolphin)
AY341076
Wilson,J.Y., McArthur,A.G. and Stegeman,J.J.
Characterization of a cetacean aromatase (CYP19) and the phylogeny
and functional conservation of vertebrate aromatase
Gen. Comp. Endocrinol. 140 (1), 74-83 (2005)
MVLEVLNPRHYNITSMVTEVAPVASIAILLLTGFLLLVWNYEDT
SSIPGPGYFLGIGPLISHCRFLWMGIGSTCNYYNKTYGEFVRVWICGEETLIISKSSS
MFHIMKHSHYTSRFGSKLGLQCIGMHEKGIIFNNNPALWKAVRPFFTKALSGPGLVRM
VTVCADSITKHLDRLEEVRNELGYVDVLTLMRRIMLDTSNKLFLGIPLDERAIVVKIQ
GYFDAWQALLLKPDIFFKISWLCRKYEKSVKDLKDAMEILIEEKRQRISTAEKLEDCM
DFATELIFAEKRGDLTKENVDQCILEMLIAAPDTMSVSVFFMLFLIAKHPQVEEAIMK
EIQTVVGERDIRIDDMQKLKVVENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGT
NIILNIGRMHRLEFFPKPNEFTLENFARNVPYRYFQPFGFGPRACAGKYIAMVMMKVT
LVTLLRSFHVQTLQGRCIEKMQKKNDLSLHPDETSDLLGMIFIPRNSDKCLDH
CYP19 chicken (three different strains of chicken)
GenEMBL M73277 to M73285, M73286 to M73294
M73295 to M73303
PIR A41063 (495 amino acids)
Matsumine,H., Herbst,M., Ou,S.-H.I., Wilson,J.D. and
McPhaul,M.J.
Aromatase mRNA in the extragonadal tissues of chickens with
the henny-feathering trait is derived from a distinctive
promoter structure that contains a segment of a retroviral
long terminal repeat.
J. Biol. Chem. 266, 19900-19907 (1991)
CYP19 Coturnix coturnix japonica (Japanese quail)
GenEMBL S46949 (692bp) PIR A48977(230 amino acids)
Harada,N., Yamada,K., Foidart,A. and Balthazart,J.
Regulation of aromatase cytochrome P-450 (estrogen synthetase)
transcripts in the quail brain by testosterone.
Brain Res. Mol. Brain Res. 15, 19-26 (1992)
Note: only three amino acid differences with chicken.
CYP19 Coturnix coturnix (quail)
GenEMBL D50336(4351bp)
Kudo,T., Yamamoto,H., Sato,S. and Sutou,S.
Comparison of 5' upstream regions of chicken and quail aromatase
gene.
Unpublished (1995)
CYP19 Poephila guttata (zebra finch)
GenEMBL S75898(3188bp)
Shen,P., Campagnoni,C.W., Kampf,K., Schlinger,B.A., Arnold,A.P. and
Campagnoni,A.T.
Isolation and characterization of a zebra finch aromatase cDNA: in
situ hybridization reveals high aromatase expression in brain
Brain Res. Mol. Brain Res. 24 (1-4), 227-237 (1994)
CYP19A1 Alligator mississippiensis (American alligator)
AY029233
MILETLNPMHYNITNVVPEAMPAATVPILLLMGFLFLIWNYEET
SSIPGPCYCMGIGALISHGRFLWMGVGNACNYYNKIYGEFVRVWISGEETLIISKSSS
VFYVMKHGHYVSRFGSKLGLQCIGMYENGIIFNNNPTLWKEMRPFFTKALSGPGLVRM
ISICVESTTDHLDKLEEVTTELGNINVLNLMRRIMLDTSNKLFLRIPLDENAIVLKIQ
NYFDAWQALLLKPDIFFKISWLYKKYEESVKDLKGAMDLLIQQKRQKLSTVEKLDEHV
DFATQLIFAQNRGDLTAENVNQCVLEMMIAAPDTLSVTLFFMLVLIAEHPKVEEEIMK
EIETVMGDRDVQSDDMPNLKVVENFIYESMRYQPVVDLIMRKALQDDVIDGYPVKKGT
NIILNIGRMHKLEFFPKPDEFSLENFEKSVPSRYFQPFGFGPRACVGKFIAMVMMKAI
LVTLLRRCRVHTQKGRGLNNIQKNNDLSMHPNERQPLLEMVFTPRSITGKCQGD
CYP19A1 Xenopus tropicalis
CX885719.1 CX885718.2 DN051995.1
best match in human = CYP19 71%, CYP19 ortholog
5697_prot from UCSC browser scaffold_27:1527865-1546466
MEALNPVQYNSTEAVPTLAPATTVSLLLFIFLLIILWNQEETCLIPGPAYCMGLGP
LISYGRFLLTGIGKAANYYNNMYGEFVRVWINGEETLVISKASATFHIMKHSHYISRFGS
KLGLQCIGMNENGIIFNSNPSLWKVIRPFFIKALSGPGLMQTTEICIRSTKRYLDNLGNV
TNELGNVDVLKLMRLIMLDTSNNLFLRIPLD
ENEIVLKIQKYFDAWQALLLKPDIFFKISWLYKKYEKSANDLK
EAIEILIEQKRQKLSSSEKLDENMDFASELIFAQNHGDLTAENVNQCILE
MLIAAPDTMSVSLFFMLVLVAQHPKIEEGIMNEIDNVIGDRDVESNDIPN
LKVLENFIYESMRYQPVVDLVMRKALEDDMIDGYYVKKGTNIILNLGRMH
RIEYFPKPNEFTLENFEKTVPYRYFQPFGSGPRAC
AGKYIAMVMMKVILVTLFKRYKVQTLGGRCLENIQNNNDLSMHPDESQPCLEMIFIPKNTAELKQ*
CYP19A1 Xenopus laevis (African clawed frog)
AB031278, SwissProt Q9IBE6 100%,
SwissProt Q68FK0 3 aa diffs
93% to CYP19A1 X. tropicalis
MEALNPVQYNITEAVPTLAPATTLSLLLFIFVLIILWNQEETSL
IPGPAYCMGLGPLISYGRFLLTGIGKAANYYNNMYGEFVRVWINGEETLIISKSSATF
HIMKHSHYVSRFGSKLGLQCIGMNENGIIFNSNPSLWKVIRPYFIRALSGPGLMQTTE
NCIRSTNHYLDNLSNVTNELGNVDVLKLMRLIMLDTSNNLFLRIPLDESEIVLKIQKY
FDAWQALLLKPDIFFKISWLYKKYEKSANDLKEAIELLIEQKRQKLSSSEKLDEDMDF
SSELIFAQNHGDLTAENVNQCILEMLIAAPDTMSVSLFFMLVLIAQHPKIEEGIMNEM
DKVIGNRDVESNDIPNLKILESFIYESMRYQPVVDLVMRKALEDDIIDGYYVKKGTNI
ILNLGRMHKIVYFPKPNEFTLENFEKTVPYRYFQPFGSGPRACAGKYIAMVMMKVILV
TLLKRYKVQTLRGRCLENIQNNNDLSMHPDESQPSLEMIFIPKNTAEFKL
CYP19 Ictalurus punctatus (channel catfish)
GenEMBL S75715(2102bp)
Trant,J.
Isolation and characterization of the cDNA encoding the channel
catfish (Ictalurus punctatus) form of cytochrome P450arom
Gen. Comp. Endocrinol. 95 (2), 155-168 (1994)
CYP19 Onchorynchus mykiss (rainbow trout)
Tanaka, M., Telecky, T.M., Fukada, S., Adachi,S., Chen, S. and
Nagahama, Y.
Cloning and sequence analysis of the cDNA encoding P-450 aromatase
(P450arom) from a rainbow trout (Onchorynchus mykiss) ovary,
relationship
between the amount of P450arom mRNA and the production of
oestradiol-17-beta
in the ovary.
J. Mol. Endocrin. 8, 53-61 (1992)
CYP19 Carassius auratus (goldfish)
GenEMBL U18974(2939bp)
Gelinas,D.M., Pitoc,G.A. and Callard,G.V.
Isolation of goldfish brain aromatase cDNA and analysis of
expression during the reproductive cycle and after steroid
treatment in vivo.
unpublished (1996)
CYP19 Oryzias latipes (medaka)
GenEMBL D82968(1851bp)
Tanaka,M., Fukada,S., Matsuyama,M. and Nagahama,Y.
Structure and promoter analysis of the cytochrome P-450 aromatase
gene of the teleost fish, medaka (Oryzias latipes)
J. Biochem. 117 (4), 719-725 (1995)
CYP19 Tilapia nilotica (Cichlid fish)
GenEMBL U72071(1804bp)
Chang,X.T., Kobayashi,T., Nakamura,M., Kajura,H. and Nagahama,Y.
Isolation and characterization of cDNA encoding the tilapia
(Oreochromis niloticus) cytochrome P450 aromatase (P450arom):
Changes in P450arom mRNA, protein and enzyme activity in ovarian
follicles during oogenesis.
J. Mol. Endocrinol. (1996) In press
CYP19 Haplochromis burtoni (cichlid fish)
GenEMBL AF114716
White,R.B.
Aromatase expression during social change in the cichlid fish,
Haplochromis burtoni.
Unpublished
CYP19 Paralichthys olivaceus (Japanese Flounder)
GenEMBL AB017182
Kitano,T., Takamune,K., Kobayashi,T., Nagahama,Y. and Abe,S.
Suppression of P450 Aromatase (P450arom) Gene Expression in
Sex-Reversed Males Produced by Rearing Genetically Female Larvae at
High Water Temperature during a period of Sex Differentiation in
Japanese Flounder (Paralichthys olivaceus)
Unpublished (1998)
CYP19A1 Danio rerio (zebrafish)
GenEMBL AF183906
Chiang,E.F.L., Yan,Y.L., Guiguen,Y., Postlethwait,J. and Chung,B.C.
Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish
Chromosomes Are Expressed in Ovary or Brain
Mol. Biol. Evol. 18 (4), 542-550 (2001)
Called CYP19a expressed in ovary
CYP19A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_7098
65% to AF183906 ovary form of CYP19 from Zebrafish
60% to AF183908 brain form of CYP19 from Zebrafish
61% to other Fugu CYP19
this is probably the ovary form
9466 MAAVGLDAEVLVSVSPNATEAESPGSSAGTRALIILTCLLLLVWSHTEKKSVP 9308 (1)
9242 SLLGPSFCLGFGPLLTYVRFIWTGIGTASNYYNKKYGDIVRVWVNGEETLVISR 9081 (2)
8985 ASAVHHVLKSRQYTSRFGSKQGLSCIGMNERGIIFNNNVTEWRKIRGYFTK 8830 (1)
8759 ALTGPAVQNTVEVCNSSTQAHLDRLEDLAQVDVLSLLRCTVVDISNRLFLDIPIN 8595 (1)
8499 EKELLLKIHKYFDTWQTVLIKPDIYFKFGWIHQKHKTAA 8392 (2)
8296 RELQEAIEGLVEQKRRDLEQADKLENINFTAELLFAQ 8186 (0)
8084 NHGELSAENVMQCVLEMVIAAPDTLSVSLFFMLLLLKQNPDVELQLLQEIDAVVGK (0 expected, bad boundary)
RQLQNGDLQKLRVLETFINECLRFHPV 7719
7718 VDFTMRRSLSDDVIEGYRVPKGTNIILNTGHMHRTEFFLRPTEFCLQNFEKN 7563 (0)
APRRYFQPFGSGPRACVGKHIAMVMMKSILVTLLSQYSVCPHEGLT 7327
7326 LDCLPQTNNLSQQPVEHQEEAQQLSMRFLPRQRGSWQTV* 7207
CYP19A1 Tetraodon nigroviridis (Green puffer)
90% to fugu CYP19A1
MDLMCDLVMAAVGLDAQAPVLVSTSQNATVSGSPGTSAGTRALIILTCLLLLVWSHTEKKHVP (1)
GPSFCLGFGPLLTYVRFIWTGIGTASNYYNKKYGDIVRVWVNGEETLIISR (2)
ASAVHHVLKSERYTSRFGSKQGLSCIGMNERGIIFNNNVTEWRKIRGYFTK (1)
ALTGPAVQHTVEVCNSCTQTHLDSLESLAQVDVLSLLRCTVIDISNRLFLDVPIN (1)
EKELLLKIHKYFDTWQTVLIKPDIYFKFGWIHQRHKAAA (2)
QELHDAIERLVEQKRREMEQADKLDNINFTAELLFAQ (0)
THGELSAENVMQCVLEMVIAAPDTLSVSLFFMLVLLKQNADVELQLLQEIDTVVGK (2)
RLQKGDLQKLLVLESFINECLRFHPVVDFTMRRSLSDDVIEGYRVPEGTNIILNT
GHMHRTEFFLRPTEFSLQNFKKN (0)
APRRYFQPFGSGPRACVGKHIAMVMMKSILVTLLSQYSVCPHKGLTLDCLLQTNNLSQQPVE HQEEAQQLSMRFLLRQRGSWQTV*
CYP19A1v1 Fundulus heteroclitus, ovarian
AY713118
MDLISSCGGTMTPVDLDGVVEDRVSIASNVTVSLSPGIPLATRT
LILLVCLLVVAWSHTEKNAVPGPSFCLGLGPLLSYLRFIWTGIGTASNYYNKKYGDIV
RVWINGEETLIPSRASAVNHVLKNGNYTSRFGSKKGLSCLGMNERGIIFNNNVALWKK
IRTYFAKAPTGPSLQQTVEVCVSSTQTHLDNLDSLAQVDVLSLLRCTVVDISNRLFLD
VPLDEKELLLKIHRYFDTWQTVLIKPDIYFKLSWIHQRHKTAAQELRDAIEGLVEQKR
RQMEQADKLDINFTADLIFAQNHGELSAENVTQCVLEMVIAAPDTLSISLFFMLLLLK
QNPHVELQLLQEIDKVIGDRELQNGDLQKLQVLESFINECLRFHPVVDFTMRRALSDD
VIDGYRVPKGTNIILNTGRMHRTEFFHKADEFSLENFQKNTPRRYFQPFGSGPRACVG
KHIAMVMMKSILATLLSQYSVCPHEGLTLDCLPQTNNLSQQPVEHHEEAQQLSMRFLP
RQRGSWQTP
CYP19A1v2 Fundulus heteroclitus, ovarian
AY428665.1
MDLISSCGGTMTPVDLDGVVEDRVSIASNVTVSLSPGIPLATRT
LILLVCLLVVAWSHTEKNAVPGPSFCLGLGPLLSYLRFIWTGIGTASNYYNKKYGDIV
RVWINGEETLILSRASAVNHVLKNGNYTSRFGSKKGLSCLGMNERGIIFNNNVALWKK
IRSYFAKALTGPSLQQTVEVCVSSTQTHLDNLDSLAQVDVLSLLRCTVVDISNRLFLD
VPLDEKELLLKIHRYFDTWQTVLIKPDIYFKLSWIHQRHKTAAQELRDAIEGLVEQKR
RQMEQADKLDINFTADLIFAQNHGELSAENVTQCVLEMVIAAPDTLSISLFFMLLLLK
QNPHVELQLLQEIDKVIGDRELQNGDLQKLQVLESFINECLRFHPVVDFTMRRALSDD
VIDGYRVPKGTNIILNTGRMHRTEFFHKADEFSLENFQKNTPRRYFQPFGSGPRACVG
KHIAMVMMKSILATLLSQYSVCPHEGLTLDCLPQTNNLSQQPVEHHEEAQQLSMRFLP
RQRGSWQTP
CYP19A2 Fugu rubripes (pufferfish)
No accession number
Scaffold_4200
65% to both brain and ovary forms of CYP19 from Zebrafish
61% to other Fugu CYP19
this is probably the brain form
2918 MKPKETLNITASGPFTPLPLPLMMMMMMLLLMMMMLFLTWNRPQRQHVP (1)
3451 GPLFLAGLGPLLSYCRFMWTGIGTACNFYNNKYGSLVRVWINGEETLILSR (2)
3674 SSAVYHVLRSAHYTARFGSRAGLECIGMEGQGVIFNSDVQLWRRARVYFSK (1)
3960 ALTGPGLQRTVGVCVTSTAKHLDCLVDMTDASGHVDALNLLRAIVVDISNRLFLRVPLN 4136 (1)
EKDLLTKIHNYFETWQAVLIKPDIFFKIGWLFDKHRRAA 4319 (2)
QELQDTMAALLKVKRKLVHEAEKLDDVLDFATELILAQ (0)
EAGEFSADNVRQCVLEMVIAAPDTLSISLFFMLMLLKQHPDVELRIVEELSTvsrt (0)
egeENIDYQRLKVMESFINESMRFHPVVDFTMRKALEDDTIEGIRIRKGTNIILNIGLMHKTE 5039
5040 FFPKPREFSLTNFEQT (0)
VPSRFFQPFGCGPRSCVG 5219
5220 KHIAMVMMKAILATLLSRYTVCPRHGCTLTSIRQTNNLSQQPVEDEHSLAMRFIPRTIQSPS* 5408
CYP19A2 Tetraodon nigroviridis (Green puffer)
88% to fugu CYP19A2
MMKPQETFAIAASGAFTPLLLLLLTMLLFITWNRTKHQQIP (1)
GPPYLVGLGPLLSYGRFIWTGIGTASNFYNNKYGSLVRVWINGEETVILSR (2)
SSAVYHVLRSAHYTARFGSRAGLECIGMEGRGIIFNSDVQLWRQVRAYFAK (1)
ALTGPGLQRTVGICVSSTVKHLDRLQDVTDASGHVDALNLLRAIVVDISNRLFLRVPLD (1)
EKELLVKIHHYFETWQAVLIKPDIFFKIGWLFDKHRRAA (2)
QELQDTMEELLDMKRKMVHESEKLDDALDFATELILAQ (0)
EVGELSADNVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPEVELKMVEELGVVSSE (1)
GDEGEENMDYQSLKVMESFINESMRFHPVVDFTMRKALE DDTIDGVGIRKGTNIILNIGLMHKTEFFPKPREFSLDNFEQT (0)
VPSRFFQPFGCGPRSCVGKHIAMVMMKAILVTLLSRYTVCPRQGCTVASIRQTNNL
SQQPVEDEHSLAMRFIPRSIPPHPPTLGRKPAHSSSHQA*
CYP19A2 Danio rerio (zebrafish)
GenEMBL AF183908
Chiang,E.F.L., Yan,Y.L., Guiguen,Y., Postlethwait,J. and Chung,B.C.
Two Cyp19 (P450 Aromatase) Genes on Duplicated Zebrafish
Chromosomes Are Expressed in Ovary or Brain
Mol. Biol. Evol. 18 (4), 542-550 (2001)
Called CYP19b expressed in brain
CYP19A2v1 Fundulus heteroclitus, brain
AY494837
MLTTGSVVVHSLCEVTPAVLLMLLLLLLLLLITARRQTRSSHIP
GPSFVAGIGPILSYGRFIWTGIGTACNYYNNRYGSTVRIWINGEETIIFSRSSAVYHV
LRSPNYTSRFGSKRGLECIGMEGRGIIFNSNIAHWKKMRTYFSKALSGPSLRRTVGIC
VSSTAKHLDRLQDMTDPSGHVDALNLLRAIVVDISNRLFPRVPLNEKELLMKIHNYFE
TWQTVLIQPDIFFKIGWLYNKHKKAAQELQDAMENLLEIKRSIINRSEKLDDDHDFAT
ELIFAQNHGELSADDVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPKVELQLVEEMSA
VLDQTAVENIDYERLKVMEKFINESMRFHPVVDFTMRRALDDDDVEGTKIKEGTNIIL
NIGLMHKTEFFPKPREFSLTNFDSPVPSRFFQPFGCGPRSCVGKHIAMVMMKAILISL
LCRYTVCPRQGCTVSSIRQTNNLSQQPVEDEHSLSMRFIPRATQPKHDRL
CYP19A2v2 Fundulus heteroclitus, brain
AY428666.1
MLTTGSVVVHSLCEVTPAVLLVLLLLLLLLITARRQTRSSHIPG
PSFVAGLGPILSYGRFIWTGIGTACNYYNNRYGSTVRIWINGEETIIFSRSSAVYHVL
RSPNYTSRFGSKRGLECIGMEGRGIIFNSNIAHWKKMRTYFSKALSGPSLRRTVGICV
SSTAKHLDRLQDMTDPSGHVDALNLLRAIVVDISNRLFLRVPLNEKELLMKIHNYFET
WQTVLIQPDIFFKIGWLYNKHKKAAQELQDAMENLLEIKRSILNRSEKLDDDLDFATE
LIFAQNHGELSADDVRQCVLEMVIAAPDTLSISLFFMLMLLKQNPKVELQLVEEMSAV
LDQTAVENIDYERLKVMEKFINESMRFHPVVDFTMRRALDDDDVEGTKIKKGTNIILN
IGLMHKTEFLPQTQRFSLTNFDSPVPSRFFQPFGCGPRSCVGKHIAMVMMKAILITLL
CRYTVCPRQGCTVSSIRQTNNLSQQPVEDEHSLSMRFIPRTTQPKHDRL
CYP19A2v1 Oncorhynchus mykiss (rainbow trout)
AJ311937
Called CYP19b (brain form)
Alt. splice form P450aromB-I
MATSIVDDTSVSGVLLLLLCLLLITAWCLTNASHIP
GPFFWAGLGPILSYSRFIWSGIGTACNYYNKRYGSMVRVWIN
GEETLILSKSSAVYHVLKSAHYTARFASKRGLQCIGMDGRGIIFNSDIPLWKKMRTYF
AKALTGPGLQRTVGICVSATDRHLERLQEMTDPSGHVDVLNLLRCIVVDISNKLFLRV
PLNEKELLLKIQHYFDTWQTVLIKPDIFFKCGWMYKRHQQAAKELQDVMESLIETKRR
IISEAEKLDDDIDFTSELIFAQNHGELSADDVRQCVLEMVIAAPDTLSISLFFMLMLL
KQNPEVEMRIVEEISTLMGENDVMTVDFQNFRVLESFINESMRFHPVVDFTMRKALED
DVIDGTKVSKGTNIILNIGLMHKTEFFPKPNEFSLENFDKTVPSRFFQPFGCGPRSCV
GKHIAMMMMKAVLVTLLSRYTVCPRHGNTLSSIRQTNNLSQQPVEDEHSLAMRFIPRQ
MTMT
CYP19A2v2 Oncorhynchus mykiss (rainbow trout)
AJ311938
Called CYP19b (brain form)
Alt. splice form P450aromB-II, short at N-term
MAGPFFWAGLGPILSYSRFIWSGIGTACNYYNKRYGSMVRVWIN
GEETLILSKSSAVYHVLKSAHYTARFASKRGLQCIGMDGRGIIFNSDIPLWKKMRTYF
AKALTGPGLQRTVGICVSATDRHLERLQEMTDPSGHVDVLNLLRCIVVDISNKLFLRV
PLNEKELLLKIQHYFDTWQTVLIKPDIFFKCGWMYKRHQQAAKELQDVMESLIETKRR
IISEAEKLDDDIDFTSELIFAQNHGELSADDVRQCVLEMVIAAPDTLSISLFFMLMLL
KQNPEVEMRIVEEISTLMGENDVMTVDFQNFRVLESFINESMRFHPVVDFTMRKALED
DVIDGTKVSKGTNIILNIGLMHKTEFFPKPNEFSLENFDKTVPSRFFQPFGCGPRSCV
GKHIAMMMMKAVLVTLLSRYTVCPRHGNTLSSIRQTNNLSQQPVEDEHSLAMRFIPRQ
MTMT
CYP19 Trachemys scripta (red-eared slider turtle)
AY533546
Crews,D.
Temperature-dependent sex determination: the interplay of steroid
hormones
and temperature.
Zool. Sci. 13, 1-13 (1996)
MMVPLLGALLLALALLSFWRLAKGKAEPGPKYPRSLPSLPIIGS
LLHLIGNRQFHLLFHSLQKKYGSLYSLQMGSHYVVVVNHYLHAKEVLLKKGKTFAGRP
HTVTSDILTRDGKDIAFATISPLWKFQRKQVHEALSVFGKGTLALEKIICREAASMCE
TLSGLQDGLLNITPELHRAVTNVVCSLCFGSWYRRGDPEFEAMLKYSQGIVDTVAKES
LVDIFPWLQVFPNKDLALLKRCVEVRDQLLQKKFKEHKEALGNDLDNDLMDALLRTQL
NMENNNSQLALPLELTDDYLLMTVADIFGAGVETTNTVLKWAVLYLLHYPEVQRKVQE
ELDQKIGFERHPQLSDRQQLPYLEATISEVLRIRPVSPLLLPHVALTDASIGEYTIPK
GARVIVNLWSLHHDEKEWDTPEEFNPGRFLDDQGKRLFSPSPSYLPFGAGIRVCVGKA
LAKMELFLFLAWILQRFTLKAPPGQPLPTLEGKFGVVLQAQPFKVQVRLREAWRDGV
CYP91B1v1 Branchiostoma floridae (lancelet, amphioxus)
Adjacent to EXOC6
37% to CYP91A1 human, 37% to zebrafish CYP19A2
39% to CYP19C3 Branchiostoma belcheri
6537 MSGVMSVLTEQLQTWSAGLTCVTAVIVTGAALVLTWGGWASGRSVDVP 6391
5431 GPPWLLGFGPLMSFARFIWMGVPVAAAHYGARYGDFVRVWIAGERTYVITR 5279
4814 PSAPWPVLKSTNSCRRFGSRTGLRPIGMYQNGIIWNGDDGWRVLRGFFQK 4656
4347 ALNADTLNRATSAAVDATYRQMGNIAALQQKAADGKIEALDFLRRITLEVTNNLTLGVHIADR 4123
3795 DDLVERIVRYFKAWEFFLLRPPIMYLMTPKLYWKHCQAV 3679
3429 NDLNDAIAELLTNKRQELKTAPPSDKPDFATCLLQAE 3319
3113 GQVSPAHVQHCVLE 3072 dup exon 7
3024 ERGEVSPAHVQQCVLEMVL 2968 dup exon 7
2925 ERGEVSPAHVQQCVLEMVL 2869 dup exon 7
2826 ERGEVSPAHVQQCVLEMVL 2770 dup exon 7
2727 ERGEVSPAHVQQCVLEMVL 2671 dup exon 7
2628 RGEVSPAHVQQCVLEMLLAGTDTSSVSMYYLLVSVAENPQVELKVLEEMRDIL 2461
2303 GERDPTKADLPQLVYLEQVIKEAMRIKPVGPVIMRQAKEDDR 2154
1890 IDGIETPAGTNIILNLADMHRRQDNFPAPDDFNPQHFDNK 1711
1067 DFKGEYVPFGTGPKGCIGQFLAMIEMKAIMCTLLRKHHLRAIPGESLEGIETHWDIAQQ 888
887 PVNASYMYFEERN* 846
CYP19B1v1-de1b2b3b Branchiostoma floridae (lancelet, amphioxus)
pseudogene fragment upstream of Cyp19B1v1
10737 MSGVMSVLTEQLQTWSAGLTCVTAVIVTGAALVLTWGGWASGRSVDVP 10591
9631 GPPWLLGFGPLMSFARFIWMGVPVAAAHYGARYGDFVRVWIAGERTYVITR 9479
9014 PSAAWHVLKSNNYCRRFGSRTGLSTIGMYQNGIIWNGDDGWRVLRGFFQK 8856
CYP91C1 Branchiostoma floridae (lancelet, amphioxus)
CYP19C1 and CYP19C2 are syntenic with CYP2U1 of medaka
39% to CYP19A1 human
RARFGDPSGLAQIGMNGSGVIFNNDVQSWKFLRFFFVK
VLDRAAGVSAIATRRQLANIRDMASSNPDGAVDVVTLMRRITLEIGNRLFLGINIEN
DLEVVNTINGYFAAWEFFMIRPKVLQLVYPTLYRKHQTAV
RALQDVVGKLVDKKRAVMNGDEAEEEFSIPKGEHDFAAALIQAQ
ECGQVSASCVRQCVTEMLVAGPDTMSVNIYFILLHIAEHGLENGILREIREVL
GDRDPTRDDLSKMVFLDHVINESMRARPVVTFVMRHAEEEDHVDGYVIPKGTNVIINLVA
VHQDPRHFPEPETFDPDHFKEK
VPSTQFMPFGLGVRSCVGRTIAPLQMKAVLITLLRMYQLSPSRDHQSLEVSRNLSEHPTEPG
SMFLYPRLETI*
CYP19C2 Branchiostoma floridae (lancelet, amphioxus)
CYP19C1 and CYP19C2 are syntenic with CYP2U1 of medaka
39% to CYP19A1 human
MLQFLVIESRGSFPLNRSRTRHGITSQIEADGCSMDTGEGWDVLLVVL
LVVLVWYYIRETWTSGIDGIFPP
GPPYIPVLTPLWTLWVFLHDGIWAATAGYAAKYGDFVRVWLGTEQTFIISR
ASAAAHVLKSSKYRARFGDPSGLAQIGMNGSGVIFNNDVQSWKFLRFFFVK
VLDRAAGVSAIATRRQLANIRDIASSNPDGAVDVVTLMRRITLEIGNRLFLGVNIEN
DLEVVNTINGYFAAWEFFMIRPKVLQLIYPTLYRKHQTAV
RALQDVVGKLVDKKRAVMNGDEAEEEFSIPKGEHDFAAALIQAQ
ECGQVSASCVRQCVTEMLVAGPDTMSVNIYFILLHIAEHGLESGILREIREVL
GDRDPTRDDLSKMVFLDHVINESMRTRPVVTFVMRHAEEEDHVDGYVIPKGTNVIINLVA
VHQDPRHFPEPETFDPDHFKEK
VPSTQFMPFGLGVRSCVGRTIAPLQMKAVLITLLRMYQLSPSRDHQSLEVSRNLSEHPT
EPGSMFLYPRLETI*
CYP19C2-de1b2b3b Branchiostoma floridae (lancelet, amphioxus)
Second gene in the region
3 aa diffs to CYP19C2
MLQFLVIESRGSFPLNRSRTSHGITSQIEADRCSMDTGEGWDVLLVVLLVVLVWYYIRETWT
SGIDGVFPP
GPPYIPLLTPLWTLWVFLHDGIWAATAGYAAKYGDFVRVWLGTEQTFIISR
CYP91C3 Branchiostoma belcheri (lancelet, amphioxus)
AB285013
CYP19 mRNA for cytochrome P450 aromatase, complete cds. ACCESSION
87% to CYP19C1 and CYP19C2 of Branchiostoma floridae
41% to CYP19A1 human, 39% to CYP91B1v1 Branchiostoma floridae
MDLGEGWDVLLLVFLVVFVWYYIRETWTSGIDGKTPPGPRYIPV LTPVWTLWVFLRDGIWAATAGYAAKYGGFVRVWLGMEQTFIISSASAAAHVLKSSNYR SRFGNPSGLAHIGMHRSGVIFNNDVRSWKAIRFFFVKALYKEVLDRAAGVSAIATRRQ LANIRDMASSNPDGAVDVVTLMRRITLEIGNRLFLGVNIENDLEVVDKINGYFAAWEF FMIRPTALQLIHPSLYRRHKTAVRALQDVVGKLVDKKRACMNGDEAEEEFSIPKGEHD FAAALIQAQESGQLSASCVRQCVTEMLVAGPDTMSVNIYFILLHIAEHGLEEGILREI REVVGDRDPTREDLNKMAFLDHVINESMRTRPVVTLVMRRAEEEDHVDGYVIPKGANV IVNLVAVHQDPRHFPEPEKFDPEHFKEKVPATQFMPFGLGPRSCVGRTIAPVQMKAVL VTLLRMYQLRPSRDHKSLDVSRNLSEHPTEPGYMFLYPRVDNS
CYP20 human
GenEMBL AC011737.8 chromosome 2 clone RP11-33N4,
AC011737.8 chr 2 (missing exons 12,13)
AC080075.2 (missing exons 1,7,8)
MLDFAIFAVTFLLALVGAVLYLYP (0)
ASRQAAGIPGITPTEEK (2)
DGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTS (1)
DPFETMLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLLK (0)
LSEELLDKWLSYPETQHVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGT (0)
VWSEIGKGFLDGSLDKNMTRKKQYED (1)
ALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQ (0)
ILEDSMIFSLASCIITAK (1)
LCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLR (2)
YCQHVLCETVRTAKLTPVSAQLQDIEGKIDRFIIPRE (0)
TLVLYALGVVLQDPNTWPSPHK (2) genomic seq stops here the rest is cDNA
FDPDRFDDELVMKTFSSLGFSGTQECPELR (2) intron site based on fish genomic DNA
FAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSSREEAWITVSKRY
CYP20A1 Pan troglodytes (chimpanzee)
XM_516042.3
99% (4 aa diffs) to human
MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGN LPDIVNSGSLHEFLVNLHEKYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFET MLKSLLRYQSGGGSVSENHMRKKLYENGVTDSLKSNFALLLKLSEELLDKWLSYPETQ HVPLSQHMLGFAMKSVTQMVMGSTFEDDQEVIRFQKNHGTVWSEIGKGFLDGSLDKNT TRKKQYEDALMQLESVLRNIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDSMIFSLA SCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVLCETV RTAKLTPVSAQHQDIEGKIDQFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRFDDE LVMKTFSSLGFSGTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSS
REEAWITVSKRY
CYP20 mouse
GenEMBL AK020848 adult retina cDNA plus ESTs for C-term
MLDFAIFAVTFLLALVGAVLYLYPASRQASGIPGLTPTEEKDGN
LPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTTDVLKQHFNPNKTSDPFET
MLKSLLGYQSGGGSAGEDHVRRKLYGDAVTASLHSNFPLLLQLSEELLDKWLSYPETQ
HIPLSQHMLGFALKFVTRMVLGSTFEDEQEVIRFQKIHG
TVWSEIGKGFLDGSLDKNTTRKKQYQEALMQLESTLKKIIKERKGGNFRQHT
FIDSLTQGKLNEQQILEDCVVFSLASCIITAR
LCTWTIHFLTTTGEVQKK
LCKEIDQVLGEGPITSEKIEQLSYCQQVLFETVRTAKLTPVSARLQDIEGKVGPFVIPKE 360
TLVLYALGVVLQDPSTWPLPHRFDPDRFADEPVMKVFSSLGFSGTWECPELXFAYMVTAV 540
LVSVLLEKLRLLAVDRQVVEMKYELVTSAREEAWITVSKRH*
Cyp20a1 rat
CYP20A1 Bos taurus (cow)
See cattle page for details
MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGN
LPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVDVLKQHINPNKTLDPFET
MLKSLLRYQSDSGNVSENHMRKKLYENGVTNCLRSNFALLIKLSEELLDKWLSYPESQ
HVPLCQHMLGFAMKSVTQMVMGSTFEDEQEVIRFQKNHGTVWSEIGKGFLDGSLDKST
TRKKQYEDALMQLESILKKIIKERKGRNFSQHIFIDSLVQGNLNDQQILEDTMIFSLA
SCMITAKLCTWAVCFLTTYEEIQKKLYEEIDQVLGKGPITSEKIEELRYCRQVLCETV
RTAKLTPVSARLQDIEGKIDKFIIPRETLVLYALGVVLQDPGTWSSPYKFDPERFDDE
SVMKTFSLLGFSGTRECPELRFAYMVTAVLLSVLLRRLHLLSVEGQVIETKYELVTSS
KEEAWITVSKRY
CYP20A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
92% to human 20A1, full seq. is not known
Ortholog of human CYP20A1
CYP20A1 Sus scrofa (pig)
DT324969.1, BG894896.1, BI336725.1, BP449309.1
Trace file gnl|ti|861177001
lower case = cow seq.
MLDFAIFAV
TFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERYGPVV
SFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKSLLRYQSDSGNMSENHMRKKLYEN
GVTNSLQSNFALLLKLSEELLDKWLAYPESQHVPLCQHMLGFAMKSVTQMVMGSTFEDEQ
EVIRFQKNHGTVWSEIGKGFLDGSLDK
NHMRKKLYENGV
TNCLRSNFALLIKLSEELLDKWLSYPESQ
HVPLCQHMLGFAMKSVTQMVMGSTFEDEQEVIRFQKNHGTVWSEIGKGFLDGSLDKSTTRK
KQYEDALMQLESILKKI ikerkgrnfsqhifidslvqgnlndqqiledtmifsla
scmitaklctwavcflttyeeiqkklyeeidqvlgkgpitsekieelrycrqvlcetv
RTAKLTPVSARLQDIEGKIDKFIIPRETLVLYALGVVLQDPGTWSSPYK
FDPERFDDESVMKTFSLLGFSGPQEC
PELGWRYMVTTVLWSVLLRRRHLLPVEGQVIETNYDLVTSS
XEEAGITVSKRFRPGILLPWLRKLTI*
CYP20A1 Canis familiaris (dog)
XM_545603.2
MGLALHGASEANGAAERALPC
ASRQAAGIPGITPTEEK
DGNLPDIVNSGSLHEFLVNLHERYGPVVSFWFGRRLVVSLGTVEVLKQHINPNKTSDP
FETMLKSLLRYQSGGANVSENHMRKKLYESGVTHSLQSNFALLLKLSEELLDKWLSYP
ESQHVPLCQHMLGFAMKSVTQMVMGSTFEDDQEVIHFQKNHGTVWSEIGKGFLDGSLD
KSTTRKKQYEDALMQLESILKKIIKERKGKNFSQHIFIDSLVQGNLNDQQILEDSMIF
SLASCIITAKLCTWAICFLTTSEEVQKKLYEEIDHVFGKDPITPEKIEQLRYCRHVLC
ETVRTAKLTPVSARLQDIEGKIDKFIIPRETLVLYALGVILQDPRTWPSPHKFDPDRF
DDESMMKTFSLLGFSGMQECPELRFAYMVATVLLSVLVRRLHLLSVEGQLIETKYELV
TSSKEETWITVSKRY
CYP20 Gallus gallus (chicken)
BU454844 603215388F1 CSEQRBN14 Gallus gallus cDNA clone ChEST201o21 5'.
BU111630 603125978F1 CSEQCHL13 Gallus gallus cDNA clone ChEST95k19 5'
BU356654 603474052F1 CSEQCHN70 Gallus gallus cDNA
MLDFAIFAVTFLLILVGAVLYLYP
ASRQASGIPGLAPTDDK
DGNLPDIIASRSLHEFLVNLHEKYGPLVSFWFGRRLVVSLGSIDLLKQHVNPNRSS
DPFEMMLKSFLRYQSSLNGDTGESHLRRKLYESGVSKSLQSNLALIQK
LSEELLAKWLSLPEAQHIPLCQHMLGFAMKSVTQTAMGSSFEDDQEVIRFRRHHDA
IWSEIGKGFLDGSLDKNATRKKLYED
ALKEMESTLRKVITGTPRQIIQQAFIDTLLQGNLSDQQ
ILEDTMIFSLAGCIITAN
LCTWAVYFLTTSEDVQQNLCKEVDHVLGKGPITHEKIEQLR
YCRQVLCETVRTAKLTPIAAQLQELEGRVDQHTVPKE
TLVLYALGVMLQDSSSWPSPYK
FDPERFSEDSAMTNFSLLGFSGSQECPELR
FAYMVATVLLSILVRKLYLHPVKGQVMETKYELVTSPKEEAWITVSKRS*
CYP20 Xenopus laevis (African clawed frog)
BC044111.1 mRNA, complete cds, SwissProt Q7ZXU7
BJ037591.1 NIBB Mochii normalized Xenopus neurula library Xenopus laevis
cDNA clone XL040p15 5'
BQ725586 BQ725586.1 AGENCOURT_8103453 NICHD XGC Emb2 Xenopus laevis cDNA
clone
95% identical to X. tropicalis seq. 74% to chicken
175 MLDFAIFAITFLLILVGAVLYLYPSSRQACGIPGLAPTEEKDGNLQDIVNSGS 333
334 LHEFLVNLHERFGPVASFWFGRRLVVSLGSLDLLKQHINPNKTSDPFQTMLKSLLGYQSG 513
514 VIGEAAESHVQKKLYENGITKALHSNFSVIIKLSEELLAKWGTYPQSQHVPLCQHMLGFA 693
694 MKSVTQTAMGSSFEDDQEVIHFRRNHDAIWSEIGKGFLDGSIERSPSRKKLYEDALMEME 873
874 TVLKKTIKERKGKNPGRHVFLDSLLQGNLSDKQVLEDSMIFSLAGCVITANLCTWAIYFL 1053
1054 TTSEEVQDKLYKEVNRVIGKGPITMDKLEQLSYCRQILCETVRTASLTPISARLQELEGR 1233
1234 VDQHIIPKETLVLYALGVVLQDNTAWPLAYRFDPDRFDDETAKQSLSLLGLSGSQECPEL 1413
1414 RFAYMVAMVLLCVLVRKLNLLPVKGQVMETKYELVTSPKEEAWITVSKRS 1563
CYP20A1 Xenopus tropicalis
DR851274.1 CX431022.2 CF240500.1 DT417160.1
From JGI blast server http://aluminum.jgi-
psf.org/prod/bin/runBlast.pl?db=xenopus1&dump=1
And from Sanger
http://www.sanger.ac.uk/Projects/X_tropicalis/blast_server.shtml
AL848968.1 Xenopus tropicalis EST, clone TEgg007o12 5'
AL870093 AL870093.1 Xenopus tropicalis EST, clone TEgg120l22 5'
60% to Fugu CYP20, 70% to human CYP20, 62% to zebrafish,
30% to ciona CYP20 like seq, 72% to chicken CYP20
MLDFAIFAITFLLILVGAVLYLYP ()
SSRQACGIPGLAPTEEK ()
DGNLQDIVNSGSLHEFLVNLHERFGPVASFWFGRRLVVSLGSLDLLKQHINPNKTS ()
DPFQMMLKSLLGYQSGVIGEAAESHVQKKLFENGIIKALHSNFSVVIK ()
LSEDLLAKWLTYPQSQHVPLCQHMLGFAMKSVTQTAMGSSFDDDQEVIHFRRNHDA ()
IWSEIGKGFLDGSIERSPNRKKLYED ()
ALMEMETVLKKAIKERKVKNPGRHVFVDSLLQGNLSDKQ ()
VLEDSMIFSLAGcvitan ()
VCTWAIYFLTTSEEVQDKLFKEVTRVIGKGPITMDKLEQLS ()
YCRQILCETVRTASLTPISARLQELEGRVDQHIIPKE ()
tlvlyalgvvlqdntawplayr () from X. laevis
FDPDRFNDETAKQSLTLLGFSGSQECPELR ()
FAYMVAMVLLSVLVRKLHLLPVKGQVMETKYELVTSPKEEAWITVSKRS
CYP20 Fugu rubripes (pufferfish)
No accession number
Scaffold_486
59% TO CYP20 human
MLDFAIFAVTFVIVLVGAVLYLYP (0)
SSRRASGIPGLNPTDEK (2)
11654 DGNLQDIVGRGSLHEFLVSLHQEFGPVASFWFGSRPVVSLGSLQQLRQHINPNHST 11487 (1)
DSFETMLKSLLGYHSGGGGASTDSIIRKKVYQGAIDTTLKNNFPLVLK (0)
LVDELVGKWKSFPEDQHTPLCAHQLVLAMKTITQLALGESFSEDARVIAFRKNHDV (0)
IWSEIGKGYMDGSLEKSTSRKGHYEK (1)
ALSEMESTLLSVVKERKSQRNKSVFVDSLIQSTLTERQ
IMEDCMVFMLAGCAITAN
VCIWALHFLSTSEEVQDRLYKEFEEVLGSSPVSLEKIPQLR
YCQQVLNETLRTAKLTPIAARLQEVEGKVDQHLIPKE
SLVIYALGVILQDSDTWNAPYR
FDPDRFEEESVKKSFHLLGFSGSQTCPELR
FAYTVATVLLSVLVRQLKLHRLKDTLMEVRSELVSTPRDETWITFNLRN*
CYP20A1 Tetraodon nigroviridis (Green puffer)
87% to CYP20A1 fugu
MLDFAIFAVTFVVILVGAVLYLYP (0)
SSRRASGVPGLNPTDEK (2)
DGNLQDIVARGSLHEFLVSLHQEFGPVASFWFGSRPVVSLGSLQQLQQHANPNRS (1)
TDSFETMLKSLLGYHSGGGGASTENIIRKKVYQGAIDATLKNNFPLVLK (0)
LVDELVGKWTSSPEDQHTPLCAHQLVLAMKSITQLALGESFSQDARVVSFRRNYDA (0)
IWSEVGKGFMDGSLEKSTSRKGRYEP (1)
ALSEMEATLLSVVKDRKSQRKTSVLVDTLLQSTLTDRQ (0)
IMEDCMVFTLAGCAITAN (1)
LCIWALHFLSSSEDVQDRLHQELEEVLGSGPVSLEKIPQLR (2)
YCQQVLNETVRTAKLTPVAAGLQEVEGKVDQHLIPKE (0)
TLVIYALGVILQDSHTWDAPCR (2)
FHPDRFEEESVRKSFRLLGFSGSQTCPELR (2)
VAYTVATVLLSAVVRQLRLHRLEDTLVEVRSELVSTPREETWITFSRRN*
CYP20 Danio rerio (zebrafish)
Assembled CYP20 from zebrafish ESTs
BQ259821 faa04d08.y1 zebrafish fin day3 regeneration
BM185037 fv16g05.x2 zebrafish adult brain
BG985721 2543 NICHD Zebrafish normalized I
BM070720 fu98e06.y1 zebrafish adult brain cDNA
CA472036 AGENCOURT_10739799 NCI_CGAP_ZKid1 cDNA (kidney?)
BI981894 fu52c12.y1 zebrafish adult brain Danio rerio cDNA
BM083017 fu28a11.y1 Campbell zebrafish ovary cDNA MLDFAIFAVTFVIILIGAVLYLYPSSRRASGVPGLNPTEEKDGNLQDIVNKGSLHEFLVG
LHDEFGSVASFWFGARPVVSLGAVNQLRQHINPNWTTDSFETMLKSLLGYQSGSGVGLTE
SMMRKKVYEGAINKTLENNFPLLLQQVEELVDKWASYPKSQHTPLCAHLLGLAMKAVTQL
AMGSRFRDDAEVIRFRKNHEAIWSQ
IGKGYLDGSLEKSSSRKAHYESALAEMESVLKSVAKQRPGQGSSQSFVNYLLQANLTER
QVMEDGMVFTLAGCVITANLCIWAVHFLSVSEAVQDRLYHELVEVLGDEPVSLEKIPQLR
YCQQVLNETVRTAKLTPVAARLQEVEGKVDQHIIPKETLVIYALGVVLQDADTWSLPYRF
NPDRFAEESVMKSFSLLGFSGSQACPELRFAYTVATVLL
STLVRRLRMHRVDGQVVEARYELVTTPKDDTWITVSKRN*
CYP20 Danio rerio (zebrafish)
ctg10765 genomic contig CYP20 74% to fugu
9501 MLDFAIFAVTFVIILIGAVLYLYP (0) 9572
SSRRASGVPGLNPTEEK (2?)
DGNLQDIVNKGSLPEFLVGLH
DEFGSVASFWFGARPVVSLGAVNQLRQHINPNWT (1) 10024
12291 TDSFETMLKSLLGYQSGSGVGLTESMMRKKVYEGAINKTLENNFPLLLQ (0) 12439
12929 QVEELVDKWASYPKSQHTPLCAHFL 13003 frameshift
13003 GLAMKAVTQLAMGSRFRDDAEVIRFRKNHEA (0) 13095
15738 IWSEIGKGYLDGSLEKSSSRKAHYES (1?) 15815 AC boundary istead of AG
15897 ALAEMESVLKSVAKQRPGQGSSQSFVNYLLQANLTERQ (0) 16010
16583 VMEDGMVFTLAGCVITAN (1) 16636
17689 LCIWAVHFLSVSEAVQDRLYHELVEVLGDELVSLEKIPQLR (2) 17811
19293 YCQQVLNETVRTAKLTPVAARLQEVEGKVDQHVIPKE (0) 19403
21269 TLVIYALGVVLQDADTWSLPYR (2) 21334
21425 FNPDRFAEESVMKSFSLLGFSGSQACPELR (2) 21514
FAYTVATVLLSTLVRRLRMHRVDGQVVEARYELVTTPKDDTWITVSKRN* from wz10135.3
CYP20 Oryzias latipes (medaka fish)
BJ524824.1 MF01SSB cDNA Oryzias latipes cDNA
BJ003683.1 BJ003683 MF01SSA cDNA Oryzias latipes cDNA
MLDFAIFAVTFVVILVGAVLYLYPSSRRASGVPGLFPTDEKDGNLQDIVDRGSLHEFLV
GLHEQFGPVASFWFGRQPVVSLGSVDPLRQHINPNHTTDSFETMLKSLLGYQAGAGGGAN
ESVMRKKLYESAINNALKNSFPAVLKVAEELVDKWSSVPEDQHIPLCAHLLGLALKTV
TQLALGERFKDDAEVISFRKNHEAIWSEIGKGYMDGSLEKSSSRKRHYE SA
LSDMEATLLAV AKDRKAQRRQTA FVDALLQSGLTERQIMEDCMVFTLAGC
VITANLCIWALHFLSTAEDVQEKLCQEVEDLFGSDPVSLDRIPQLKYCQQVLNE
TVRTAKLTPVAARLXEVEGKVGQHVIPKETLVIYALG
VVLQDADTWSTPYRFDPDRFQDESARKSFCLLGFSGSQTCPELRFAYTVATVLLATLVRRLKLRPLK
About 26 aa missing at end
CYP20 Salmo salar (Atlantic salmon)
GenEMBL CA063128.1 ssalrgb509318 mixed_tissue Salmo salar cDNA.
GenEMBL CB516811.1 ssalrgb509318_rev mixed_tissue Salmo salar cDNA.
GenEMBL CB513409.1 ssalrgb531212_rev mixed_tissue Salmo salar cDNA.
BG935303.1 SL1-0624 Atlantic Salmon liver Salmo salar cDNA clone SL1-0624
MLDFAIFAVTFVIFLVGAVLYLYPSSRSASGIPGLNPTEEKDGNLQDIVNRGSLHEF
LASLHGQFGPVASFWFGGRPVVSLGSVDQLRQHINPNRTTDSFETMLKSLLGYQSGTGGG
ATEAVMRKKLYESAVNNTLEKNFPMLLKLVEELVGKWQSFPKDQHTPLCAHLLGLAMKAVTQ
18 amino acids missing here
RKNHEAIWSEIGKGYLDGSMEKSSIRKEHYESA
LAEMETVLMSVAKDRKGQRSQTAFVDTLLQSNLTERQVME
DSMVFTLAGCVITANLCIWAVHFLST
SEDVQEKLHQELEDVLGSEPVSLDK IPQLRYFQQVLNETVRTAKLTPIAARLQENEGKVD
QHIIPKETLVIYALGVVLQDADTWSCPYKFDPDRFTEDSARKSFSLLGFSGNQACPELRF
AYTVATVVLSTVVRQLKLYQVKGQVVEARSELVSTPKDDTWITVSRRS*
CYP20 Ciona intestinalis
SEQUENCE 186, 187 CYP20 ortholog
29% to fugu CYP20 CYS = HIS
MLEVHVTITAVAVLAVILLLFLIGLLFYIYPSSN (?)
KETTVPGPAVSDIR (2)
DGNRSDIDRAGSLHQYLCNLHAEHGDLASFHFDKQLIISIADSKYFAPRSQVFQLP (1)
DFLYEFWEPMIGKESFVFSQGVDVFKRRDNIDFKVDKKVKEFYAKIF (0)
RLLAIELEEKWRKQPEDQHIPLTQHLKGLATKAVCQMMFGESFADDERVIKLYKAWDK (0)
CWNEVMAASKMEPTKSESDEKK (1)
SIKELRSLMEKAIEERWKKSKHLDGITLLDGLLASSNSSVSPLSSEQLLCDVITMFTMGVQVTNA (1)
VLCWSVYFIAAHDDVQTKLRNKLNEVESLDIMPQSLNDVK (2)
YMQSILKESIRCSGVFSYSGRVEDIDITVGDHLLPKG (0)
TPIIEALMFPMQSDAFESPDM (2)
FNPKNFSEATKSVNPLTYIPFAFGGSRHKPQDS (2)
LVYLLVSITVASLFRNLRISLAGKEVDPQSANYESFVALPSTEEVWVTVGGKLDVETVGENN*
CYP20 Ciona savignyi
sequence for CYP20 ortholog
72% to C. intestinalis seq 186
MLEVHVSITAVAILVLIILLFLIGLLVYIYPVI (2)
KETTVPGPDVSDAK (2)
DGNKSDIERAGSLHAYLCNLHADFKHEGAVSFHHGKQLVISISNPKFFAPRSQVFQLP (1)
SFLYEYWRPLIGEESFLFAKDIDVFRRRDYLDFKVNRNVKEFYAKNF (0)
LAVELETKWEKQPEDQHIPLTQHLKGLATKAVCQMMFGDNYADGTKVLELYRAWDK (0)
CWNEVMAASKMEPTKSESVEKK (1)
SISELRKLMENAIEERWNKSKSLDGITLLDGLLSSQTSDSKDQLTSEQLLCDVITMFTMGVQITTA (1)
VLCWSCYFVASNKEVQRKLKNQLNESKSLDIMPETLMDME (2)
YMQGILKESVRCSGMFSFAGRVEDIDITVQNHLIPKG (0)
TPILEAIMTEMRSEAFSCPDV (2)
FNPKNFTKDNNHLNPLTFIPFAFGGSRHKPEES (2)
LVYLLAAVTVSSLFRNLQVSLAGKEIEPFAANFESFVAMPSTEEIWVTVSKEKEVENVG*
CYP20 Halocynthia roretzi (tunicate, Urochordate)
AV385510
51% to CYP20 in Ciona
KYMKMVLKESLRSGCVFSWAGRQQDIDINVGGNLITKYTPVIEAIGTAMTDEGNFSDPSE
FDPKRFSEDNDEVINPLDYIPFGFGGSRKAPQNSLVFLLASIVASTLIRNLKVCIAGDSS
QNQPDPDFSAFVSRPSKEELWVTVSALGKKKAETVG*
CYP20 Molgula tectiformis (tailless ascidian, tunicate, Urochordate)
CJ366548.1 EST
N-term
MDVQITLATLGVFIVLFVLFLLGFLFYLYPGSNNQSTIPGPNPSDAKDGNVSDLQ
RVGSLQKYLEELHSEYGDIIAFWHQSNQIVSIADLDEFAQTNQVFERPDILFSSWIPLIG
KDSFIFEKDVKNFQRLDML
CYP20 Branchiostoma floridae (amphioxus)
There are 8 CYP20s in amphioxus (see the amphioxus page)
CYP20 Saccoglossus kowalevskii (Acorn worm, hemichordate)
FF488963, FF488605, FF525072, FF503042, FF480950, FF429742
38% to Paracentrotus lividus, 30% to CYP20 human
33% to sponge CYP38A1
MTALVIIVVVLLVVVVAVFYLGTLFGSKQEQMLARIPGMNPTNSED
GNMPDITVAGSLHEFLVKLHTKYGHVATFWYGKTHVISLASAKAFKDTNKLFDRPAVLFNFVKPLIGPD
SIQYANEEDGKRRRHDYDQSFSYDAIKNYYSKFYEATDAVVAKIESLPSDEHINITEHMS
LLVLKALSHATYGDFFKDDEFSITMLRHYETAMAILNQDISKDTEAGQ
RFAQALKTWHDFIRAMIQHRRDNPPNDDDWTFIDVLMAKSSSEEELISDATSYF
IAGYHTTAFMMVWTFYYMCENQEVQEKIYQEIIEVIGKDEQVNYVNLESLKYMRCVFD
ESMRCSVLAPFAARVNMHADMVVQGYTIPKGTPVVHALGVVLMDDEIWSEPERFIPERFL
PXNVSTRHPLSFQPFGFAGKRKCPGYRIAYAEGAVFLATLCRK
FKFQLVEGQTIERKYGFVTIPSNDIWVTVTKRD*
CYP20A2 Saccoglossus kowalevskii (Acorn worm, hemichordate)
FF425228.1
45% to CYP20A1 Saccoglossus
N-term region
FFQFVKPLFGENSIQFANGNYGKQRRKLHDASFTHQAVKSYYPVFQEKTEIFIRKIMAPP
PEEHIPLSEYVSVFVMKSLMSALFGQNVENDEQTVTMLRHYETVMLVLNKKMSANTEKKN
TFHIALNAWHEFIRKIILKRRNEPSDE
CYP20 Strongylocentrotus purpuratus (purple sea urchin)
GenEMBL XM_787803.1, XM_793215.1
AAGJ02125342.1 (middle piece, two exons that were missing)
85% to Paracentrotus lividus
37% to CYP20 Saccoglossus kowalevskii (acorn worm)
35% to sponge CYP38A1
MLDFAIFAVTFIILLVGLLIYIYP (0)
TTPQKTTTVPGLEPSDPV (2)
KGNLDEIGDAGSLHQFLTKLHAEHGDIASFYFTDQLCVSITSPELFKEHQAVFNRP (1)
ALLFKLFEPLITPDSIQYANGGDGRKRRDLTDRCFGFQALQNFIGVFNK (0)
ITEQLVKKISALPPGEHISLHGTGLGLAIKGIMLTSFGDYFQDDKSITSFRKDYDF (0)
VWGEMEARLDGNMPDEGSNRVKTFEE (1)
1967 ARERMYATIQAVIKFRRSNPPSQDKEVFIDVLLKADYPPGRLQADLLTYVIGGFHTSGN (1) 1791
359 LFAWALFFLAEDDKIQEKLYNHVIDIVGKTGEVSMEDIAEMT (2) 234
YMRQVIDETLRVSILAPYAARYQDFDVVLGGHVIPKG (0)
TPVIHALGVSLQSEKYFPNPKT (2)
FNPENFSAANVKKRPRDAYHPFGFAGRRVCPGQQ (2)
FAYKEVAIFLAVFIRAFKVKVVPGQKPEHVHGLVSHLVNKDGGEVWITVEKR*
CYP20 Paracentrotus lividus (common urchin, Deuterostomes)
AM536943, AM531351, AM584793,
AM534834, AM554260
85% to CYP20 Strongylocentrotus purpuratus
32% to human CYP20 (best match in human) first 11 aa identical
37% to sponge CYP38A1
CYP20 has a highly conserved N-terminal
MLDFAIFAVTFVLLLVGLLIYIYPTTPQKSTTVPGLEASDPVKGNLDEIGDAGSMHQFLTKLHED
HGDIASFYFTDQLCVSIASPELFKEHQAVFDRPPLLFKLFEPLITPDSIQYANGSDGRKR
RDLTDRCFGFQALQNFIGIFNKITEQLVEKISALPPGEHVPLYSTGLGLAIKGIMKTSFG
DYFKDDKSINSFRRDYDYVWAEMEARLDGSMPEPES
EREKKFDEARERLYDTIRGVIKVRRSNPPSQDKEVFIDVLLKADYPPGKLLADL
VSYSVGGFHTSGNLFAWALYFLAQDEEIQEKLYKHVIDIVGKTDEVGMEHIAKMTYMR
QVIDETLRVSILAPYAARFQDFDVVLGGHVIPKGTPVVHALGVSLQSEKYFPNVKVFNPE
NFSPANVKKRPRDAFQPFGFAGRRVCPGQQYAYKEVSI
FLAVFLRAFKIKLVPGQKTEHVHGLVSHLVSKDGGDVWFTVEKR*
CYP20 Rhipicephalus appendiculatus (brown ear tick, arthropod, arachnid,
ecdysozoa)
CD784670.1
35% to CYP20 Danio, 39% to CYP20 human
N-term
MLDFAIFAVCFVVFLLALVLYLYPSSAKQTTIPGLEPSDKKEG
NVGDIVQAGGLQNFLISLHKEHGPIASFWIGTKLVVSIGKADLFKTQSHVFDKPAELFVL
YRDVMGAGSIFFANGAEARKRRRLIDEVLTGKSLDKFLGPIEKLCSEVVMHLKDTPDDEH
VPVYQYMYALCMKISTRLLFGEYFFDDMEVLKFSRNFELCIKELEE
CYP20 Ixodes scapularis (blacklegged tick, arthropod, arachnid, ecdysozoa)
EW872941.1
EW945756.1
N and C-term with a gap in the middle
MLEFAIFAVCFVVFLLMLVVYLYPGSSKQT
TIPGIDPSDPKEGNVGDIVQAGGLKNFLLSLHKDHGPITSFWMGTKLVISIGDAELFKTQ
THIFDKPADLFELYRDLVGADSILFANGAEARQRRRRLDDVLTGDRINDFVGPLQKMCAE
VVDRWESLPAEEHVPIYQYMYALCMKTCTRLLFGDYFFDDKHVLSSAGPLSCVSVLQRCC
ACPRPDSLDQSMR
MTWALYFLATH
LKLQDFMQLSNLQKTIKETLRTATVEPWTARCQDVDVEIAGHVIPKKTPVIQALGVVLHE
EDHWKVPHRFDSSRFNEKFPELAYCPFGFAGMRLCPGKDLSVLHMSVFLVTLCHRL
KLRLIQDQVVTPTFALITKTDDEVWLTLERRRP*
CYP20 Amblyomma cajennense (tick)
EC780049.1 EST
N-term
MLDFAIFAVCFVVFLVALVVYLYPSSTKQTTIPGLGPSDAKEGNVGDIVQA
GGLQNFLVSFYKEHGPIASFWIGTKLVVSIGQGELFKTQSHVFDKPADLFVLYREVMGTG
SIFFANGAEARKRRKLIDDVLTGQRLDKFTLPIEKLCSEVVA
CYP20 Helobdella robusta (leech, annelid worm)
JGI gene model fgenesh4_pg.C_scaffold_12000405 [Helro1:168041]
Helro1/scaffold_12:3739808-3743927
28% to CYP20 Saccoglossus kowalevskii,
29% to Strongylocentrotus purpuratus CYP20,
30% to Paracentrotus lividus CYP20
33% to Amphioxus CYP20
MLDYLIFAATVVVFLILAVIYLYPGSKKSIDIPGPEPVDPLEGNYPDIKACGSLHEFLVDLHETYGPICS
FWAGPQLCVSVASPELFSEQANSFNRPVELFKAQTLLWGENSPFVLNGAEGRKKHAFLTGIFNEKYASCS
LKLEHEILKKQTASWLKWPNEQFFPLYEKISGFVVKFLLSSHFGYDAENSKDVNVIKGNLDNVWQEVGHY
MDDTSDADGLRDIRFEQYKKKLKSFISDALILRKTLPTVSDPAKLPIDHVLQLSEEEAVSILLLLFTNAY
MKYCSLFTWMGYFLALEPHVQDQVRKELGSIPIEEINLANCNEFKYFKKVFQETLRCANIVSHTARIQNT
DIVIQNSKIPAN (0)
TPVIQSLGVVSSNPTIFHEPDK (2)
FNPDRHASKNTPCSSFAS
3747683 QYFGFAGKRICPASSIVMSQAALFFAHVLECFSLTLAPDQVVSSHYGLFA 3747832
3747833 KPKEEIWLSV 3747862
ENINVRRVS*
CYP20 Haementeria depressa (leech, annelid worm)
CN807321.1 EST
67% to CYP20 Helobdella robusta
NAYLKYSSLLTWMGYFLALEPDVQHKLRKELGLVSVSDLSSVNINKFKYFQNTLKETLRC
AKIVPYTARIHNTDIVIKKDKIPANTPIIHALGVVSSDPAIFPEPDEFNPERFDSKNKPN
TFACQSFGFAGKRKCPASSTVASHAALFYSHLLDCFELKLAPDQIVSSHHGLNAKPKEEI
WLSLEM
CYP20 Hirudo medicinalis (medical leech, annelid worm)
EY484183.1 EST
VEADKLNMQDMXRLDYLQLVTKEVLRCAGIVPFTARCQNTDSQLESHRIPAG (0)
TPVLHAIGVVSNDSQIFDNPEE ()
FNPERFKNVNPSQFAFHPFGFAGQRTCPGSQVAIAQVATFYAHVLRSFELELAPNQ
LAAPNHGFYVRPKEEVWLTLKARL*
CYP20 Eisenia fetida (earthworm, annelid worm)
EH670454.1, EH670439.1 ESTs
ANKMKYLNQVLKETLRVARIATFAARVHHSDVVLGGYQVPAEMPILHAIGLSLHDEEVFP
HPLKFDPDRFSVENEKHLPPFSFEPFGFSGKRKCPGYNFSYAEATVYLSLLIRSFKIELA
FDQVAESKFGFVTKIKDDLWVIARPM*
CYP20A1 Capitella sp. I (polychaete worm, annelid)
JGI gene model e_gw1.28.81.1 [Capca1:145552]
+ e_gw1.28.94.1 [Capca1:145544]
Capca1/scaffold_28:376236-381170
And Capca1/scaffold_28:374918-376952
upstream region with N-term
45% to Amphioxus CYP20, 41% to Strongylocentrotus purpuratus CYP20
34% to Helobdella robusta CYP20
MIQFLLFAVFFLVVLVVTVIYLYSGSGSRKSTIPGPEPLDDLEGNNAD
IKASGSLHEFLMDIHADYGPMASFLFGPQLVVSICCPDLYKQYLKTFDRPASLFEFLEPLITANSIQFAN
GAEGRMRHSAYMRSFGDSMVKNYYPMLQ KFASDLTRSLQLEAKETHIPLRKYMFAFAIKAMLRGAYGKYF
DSDEEIHKLRAAYDVCWTDLEHRLLGDLPVEGSKRDERFEKNKKIMYDIMQKVLDDRRSNPPENDERCFV
DALIDLDVSEDVKKSDMLTVLIAGFHTTGLLLTWCLYYLAKHEEIQDKLLGEIEAVLGKDGVVKADN VHQ
LPYLRQVLNESLRCSVLAPFAARVQSTDVEIGGHTIPANTPVLMALGVTLCNDEFYPDPEIFDPERFTEE
NMKNRPSLAFEPFGFGKRKCLGYKFSMAEFSVLIPTLIRHLKVELVPGQVVTPMFGLVTTPTDEIWVTVS
ERK*
CYP20A1P Capitella sp. I (polychaete worm, annelid, Lophotrochozoa)
JGI gene model fgenesh1_pg.C_scaffold_1378000002 [Capca1:185650]
Capca1/scaffold_1378:17781-19064
Pseudogene
51% to the N-term and
72% to the C-term of the whole gene in Capitella
& = frameshift
MIPIIYLLVVILVVIVLAALFVQAGNSQIRKSTIPGPKPRNKHEGNLADIRAIGSLHQFLLNLHGNFGPI
ASFHYGAQMVVSISSPDLYKKYLKTFDRPPVLFEFPMISKHSLLLTNGQDAHIRREAYLHTFSDVAIKQQ
YPMLQG
(deletion of 179 aa)
LHQIP&
FLRQVMNESVRCSVLGAVAGRVQAVDVEVGGHQIPAH (0)
TPVVMAIGVTHVNEEFYPAPERFDPGRFTEENVKSRPSLSFNPFGFGKRKCLGYKFSNAEFYVF
ITTLLRCLKVELVPGQVVTPLYRVVTTPADEVWVTLSPRY*
CYP20 Lottia gigantea
jgi|Lotgi1|82740|gw1.84.105.1
37% to CYP20 Danio
EST FC700835.1
MLDFAIFAVTFFMMLVGAVIYLMPSSRKATSVPGLDPTTKEDGNLSDIGRAGSLHEF
LLDLHGRFGDIASFWMGRQLVISIASPELFKQHQNVFDRPVELFKVFEPVIGERSIQYCN
GNDGRARRQTYDKSFSHHELFSYSPKFQEVADNLVKTLENKVKEEHLSLNQYMIAYAFKT
VMNSLYGDAMDDEKDIIAMRGHYDIMWSEMEKRIADPTVPEDGSPRAISLNLALKEMRKI
VQNIIDFRKKNGKKSEDYLLIDRIVEHMKTEDGIFSEILTFL IGGFHTAGNLLTWAVYFL
ATHEEVEKKLLKEIKNVLGDDDISADNYDQLKYTKQIIDETMRCAVVAPWAARYQDFDSE
LGGHKIPKKTPVIHALGVSLQDERQWPQPKIFDPERFNEENIKKRPHLAFSPFGFAGRRV
CPGRKFAYLESAICLVSLFRRFKFHLVEGQVVQPVFGLVTHSEDDIWVTVSKR*
CYP20 Aplysia californica (Califonia sea hare,mollusc, Lophotrochozoa)
EB277115.1, EB214176.1, EB282241.1
MLDFVIFAVTFLTVLLVAIIWLYPSSKKVTTIPGVDPSSK
EDGNFSDITRAGSLHEFLLDLHSQFGDIAGFWWGQTYVVSIASPELFKAYANVFDRPTELFRF
IEPLISMQSLQFTNGSDGRMRRKAYDRPFSHENLKKHFAEFQTIAGIVEQKWSKKSESDH
IPLGEDMALFSVRATLLTLMGDSFQ
(gap)
VGALHTSAYMLTWAMYFLATH
xxxxxxxxxVQVLGQKDVVTDSNYGQLRYLYQVLQETLRCAVVAPWGARVQDFDTELGGHKVPTK
TPVIHALGVVLQNEKLCPLPKRFDPDRFSTENSKDQPTYAFSPFGFAG
KRTCPGYKFANRGSTVLIATLIKKFEVSMWSDQVVKPVFGLVTRPHEEILLKVSRRK*
CYP20 Crassostrea virginica (Oyster, mollusc, Lophotrochozoa)
EH649216.1 N-term
MLDFVIFAVTFVVALLIAVIYLYPGSKRITTIPGPDLTTKED
GNLADLARAGSLHEYLLDLHAQYGDITAFWMGQELVVSICSPDLFKQHSTVFDRPVSLFK
MFEPLIGEKSIQYANKADGRNRRKLYDPVLSSDYLHHYYTAMQEVSDSLVKKWSSLPKEE
HVPVAQYMIAQALKMA
CYP20 Mytilus californianus (mussel, mollusc, Lophotrochozoa)
ES406577.1 EST
EGGARFQDF
DSELGGHKIPKNTPVIHALGVTQQDEAIWPVPNRFDPDRFSEENSKKRQSLAFQPFGFAG
KRICPGYRFAYAEATVCFVTLLRKFKFNMVEGQVITPVHGLVAHPSEEVWITIDKR*
CYP20 Nematostella vectensis (starlet sea anemone, Cnidarian)
XM_001634458
matches genomic seq NZ_ABAV01008690.1 and ABAV01008690.1
40% to human
31% to CYP20 HUMAN
missing N-term
14466 (2) aga NGNLLDVKKAGSLHEYLLLLHKTYGPVASFMWGTINVVSVADPTLWKE
LRSLFDRP (1) 14639
15646 PELFKLFEPLIGKKSIQYANGVHGRKLRQLFDRGFSHQAVKDYYQ (2) SFIE(0) 15792
15931 (2) DCCSDWFFLCPQVAEKVANQWVIKSSDEHIPIVESMLMLAIRAIGKAGM
GKRFSAEKDVQAFMNAYRT (0) 16134
17805 TWEEMEACLNGSLSTKGSKRDQRFQN (1) 17882
18216 DMEVMRKMIRETISARRNQRTSSPEPLFIDSVLDCDFIDEKEVRK 18350
18790 EDDMISFFVGGFHTTGN (1) 18840
19760 MMSWCFYYLAIHPEIQEKVHQELIDVLGNDAIDPQAASELQ (2) 19882
20039 FCRQVLDETLRCAVVAPWGARVQYDHDLQIGEYVVPKG (0) 20152
20626 TPIITPFGVVLQDPELYPEPQM (2) 20691
21349 FDPDRFSPEAMKELPSHAYEP 21411
21412 FGFAGKRKCPGWRFSIAEGLVFLSVFVRRFKIRLVPGQKVEPVYGLVTTPKEELWVAVEKRK* 21600
CYP20 Hydra magnipapillata (hydra, Cnidarian)
BP508840 BP508840 ESTs
ABRM01022129.1 ABRM01019337.1 genomic
36% to CYP20 C-term
7448 aga LGNLGSLTFDGGIHKFLVENHKRLGPMFSFYWGKELAVSLACPILFKEVATLFNRP (1) 7615
9076 VNQFKLFLPLIGKECVQYANEDRGKKLRQINDRHFSHSSIKSYFKEFKQ (0) 9222
YFLLKVGAELCSKWSSSENTRIPLNQNMLSIAFKTIVKTSFG
agt YTKQVIDEVMRIAVLAPYAARYSDYDIIVDGHLIPKK (0)
TPIILALGTVFQDETIFPEPDRFDPDRFSDKQIEERSALAFQPFGF
AGKRKCPGYRLAYAETLTYTFYIIKNFHISLFDKQSVKMHYGFVTKPSEEIWIKVLRRKNI*
CYP20/CYP38A1 Suberite domuncula (sponge)
GenEMBL Y17816 (1789bp)
Mueller,W.E.G., Wiens,M., Batel,R., Steffen,R., Borojevic,R. and
Custodio,M.R.
Establishment of a primary cell culture from a sponge: Primmorphs
from Suberites domuncula
Mar. Ecol. Prog. Ser. In press
Name change to CYP20 is recommended
MLDFVIFAITAVAGLIGILLFFYFSRSTETKPVSSASPTSTIPR
WSAPPADIEKGDLDVMMKKHGSLHQFLLHLHDNGKTPVTSFWWGKTHVVSFCSPQAFK
ESAVFVNRPVELFVGFEPLITPFSIQYANDEDWVQRSKCLYHTLKGDDLKSYFHHFVQ
IAQEEESLWSSYTSDKEVSLTKEVFPMTIKGIARTCFGDIFKDENELSKMAESYHVCW
RTMEEGVPEAGSKRETEFLKHRRVLEDIIRRIIQERKEGEDLQELPFIDSMLQNYDSE
DKIIADAISFMVGGFHTSGYMFTWMLWYLSSHPESQDRLRTEIERETGGERGDRLKEY
SLRADTFLRQVQDETIRLSTLAPWAARYSDKKVTVCGYTIPAKTPMIHALGVGLKNKT
VWENTDSWDPDRFSPNGRRGNDFCPFGVHSRRKCPGYLFSYFEVGVFASILLSRFEIV
PVEGQTVIQVHGLVTEPKDDIKIYIRSRKED
CYP20 Schmidtea mediterranea (freshwater planarian)
NZ_AAWT01057969
34% to Paracentrotus lividus
33% to Strongylocentrotus purpuratus
32% to Saccoglossus kowalevskii
25% to human CYP20
from SmedGD database
Missing first exon
23008(2)aga KPKQIVIIPGLQKSDPK(2)
22918FGNLLEIKNSGSLHQFLSDLHLKFGAVATFYWNDQKIVSVCSNDLFKSVQDLFDRPSLI
FGNFHEFIGENCLQYANGNEGQNRRKQYDKAFQHDMIIR(2)22625
18726 YISTIENVGKSNLEEWHGSKVTVDSIEHWAYIMAVKSILKACIIPEEQSPEYCDTIITLYKS
VFIGLEKKFVECKVLSDEEEIQFQKDKNQFYSIIREIINKRLDFLENSDLENEKLLLIDY
IILYHRELNRNLIENEVLIYLIGGFHTT(1) 18274
13764(1)GNALSWCIYYLAKHPKCQEKLFTEISKRQIQLQNTSECYKLILD
LKYLKACIEETLRLSQLAPYAARVSDEDRYLSNYEVPANTPIILALGVSLKDEKI
FNNPDQFNPERFVDSNFPSFAFVPFGFAGKRKCPGER(2)13357
13304 FSYLELSIWLIQLVGKYRFTLTNPHQTVNKVYGLVTRMSENVSVQFGERSDVL*13143
21A Subfamily
CYP21A1P human
GenEMBL M13935 (3206bp)
White,P.C., New,M.I. and Dupont,B.
Structure of human steroid 21-hydroxylase genes.
Proc. Natl. Acad. Sci. U.S.A. 83, 5111-5115 (1986)
97% to 21A2 NT_033167.1|Hs6_33343
329415 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLLPLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQ 329215
329117 DVVVLNSKRTIEEAMVKKWADFAGRPEPLTCK 329022
LVSKNYPDLSL
328702 XXWSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCE 328592
RMRAQPGTPVAIEEEFSLLTCSINCYLTFGDKIK 328383
328294 EDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLR 328193
328091 FFPNPGLRRLKQAIEKRDHNEEKQLRQHK
327835 ESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHLHMAAVDLLIGGTETTANTLSWAVV
327654 FLLHHPE 327634
IQQRL*EELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLWPVV
327292 PLALPHRTTRPS 327257
SISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWP 327069
326971 DRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPH
326791 CSVILKMQPFQVRLQPRGMGAHSPGQNQ 326708
CYP21A1P human with congenital adrenal hyperplasia
GenEMBL M26857 (4034bp) X05445
Rodrigues,N.R., Dunham,I., Yu,C.Y., Carroll,M.C.,
Porter,R.R. and Campbell,R.D.
Molecular characterization of the HLA-linked steroid
21-hydroxylase B gene from an individual with congenital
adrenal hyperplasia.
EMBO J. 6, 1653-1661 (1987)
CYP21A1P human
GenEMBL S60612 (426bp)
Collier,S., Tassabehji,M. and Strachan,T.
A de novo pathological point mutation at the 21-hydroxylase locus:
implications for gene conversion in the human genome.
Nature Genetics 3, 260-265 (1993)
CYP21A1 Canis familiaris (dog)
GenEMBL AB039881
MLLLGVLLLTVLAGARLLWGKWKLRGLHLPPLVPGCLHLLQPDL
PLHLLGLTQKLGPIYRLRLGLQDVEVLNSKRTIEEAMVRKWVDFAGRPQTPSYKLVSL
HHQDLSLGDYSLLWKAHKKLTRSALLLGIRSSMEPLVEQLTQEFCERMRAQAGTPVAI
QKEFSLLTCAIICHLTFGNKEDTLVHTFHDCVQDLMRTWEHWSIQMLDIIPFLRFFPN
PGLWRLKRALENRDHIVEKQLRQHKESMVAGQWRDMTDYMLQRVGRLRAEEGCGQLLE
GHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQQRLQEELDRELGPGASGSRIPY
RDPTRLPLLSATVAEVLRLRPVVPLALPHCTTRPNSISGYDIPEGMVVIPNLQGAHLD
ETVWERPQEFRPDRFLVPGASPRVLAFGCGARVCLGEPLARLELLVVLAQLLRAFTLM
PAAGTLPSLRPRARCGVNLSMQPFQVQLQPRGAGVLGRGQHP
CYP21A2 human
GenEMBL M21544 M21545 M21547 to M21550 M23224 M23225
M31022 M31023 (ten segments)
Globerman,H., Amor-Gueret,M., Parker,K.L., New,M.I. and White,P.C.
Nonsense mutation causing steroid 21-hydroxylase deficiency
J. Clin. Invest. 82, 139-144 (1988)
CYP21A2 human
GenEMBL M12792 M23280 (5141bp)
Higashi,Y., Tanae,A., Inoue,H., Hiromasa,T., and
Fujii-Kuriyama,Y.
Aberrant splicing and missense mutations cause steroid 21-
hydroxylase [P-450(C21)] deficiency in humans: possible gene
conversion products.
Proc. Natl. Acad.Sci USA 85, 7486-7490 (1988)
CYP21A2 human
GenEMBL X54940
Partanen,J. and Campbell,R.D.
Rapid characterisation of mutant P450c21 Genes by PCR
unpublished (1993)
CYP21A2 human
GenEMBL X58898 to X58908 PIR S26485 (97 amino acids)
PIR S26484 (371 amino acids) PIR S29670 (495 amino acids)
PIR S29671 (372 amino acids) PIR S26584 (371 amino acids)
PIR S29673 (372 amino acids)
Helmberg,A., Tabarelli,M., Dobler,G. and Kofler,R.
Identification of molecular defects causing congenital adrenal
hyperplasia by cloning of PCR-amplified 21-hydroxylase genes
unpublished (1992)
CYP21A2 human with congenital adrenal hyperplasia
GenEMBL M28548 (4044bp) X05449
Rodrigues,N.R., Dunham,I., Yu,C.Y., Carroll,M.C.,
Porter,R.R. and Campbell,R.D.
Molecular characterization of the HLA-linked steroid
21-hydroxylase B gene from an individual with congenital
adrenal hyperplasia.
EMBO J. 6, 1653-1661 (1987)
Note: mutant gene, 2 amino acid differences
CYP21A2 human with congenital adrenal hyperplasia
GenEMBL M26856 X05448 (4042bp)
Rodrigues,N.R., Dunham,I., Yu,C.Y., Carroll,M.C.,
Porter,R.R. and Campbell,R.D.
Molecular characterization of the HLA-linked steroid
21-hydroxylase B gene from an individual with congenital
adrenal hyperplasia.
EMBO J. 6, 1653-1661 (1987)
Note: normal gene
CYP21A2 Pan troglodytes (chimpanzee)
XM_003311189
99% (5 aa diffs) to human
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPD LPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVS KNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVA IEEEFSLLTCSIICYLTFGDKIKEDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRF FPNPGLRRLKQAIEKRDHIVEKQLRQHKASLVAGQWRDMMDYMLQGVAQPSMEEGSGQ LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSR VPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGA HLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF TLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ
CYP21A2 Papio hamadryas ursinus (chacma baboon)
EU342417
MLFLGLLLLLPLLAGARLLWNCWKLRSLHLPPLVPGFLHLLQPD
LPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVS
KNYPDLSLGDYSLLWKAHKKLTRSALLLGMRDSMEPVVEQLTQEFCERMRAQAGTPVA
IEEEFSLLTCSIICHLTFGDKIKEDNLVPAYYKCIQEVLKTWSHWSIQIVDVIPFLRF
FPNPGLRRLKQAIEKRDHIVEKQLRQHKESLVAGQWRDMMDYMLQVVAQPSMEEGSGQ
LLEGHVHMAAVDLLVGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHQLGPGASSSR
VPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNFQGA
HLDEMVWERPHEFWPDRFLELGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF
TLLPPGDALPSLQPLPHCGVILKMQPFQVRLQPRGLGAHSLGQNQ
CYP21A1 Bos taurus (cattle)
GenEMBL M11267, M13545
Chung BC, Matteson KJ, Miller WL. (1986) Structure of a bovine gene
for P-450c21 (steroid 21-hydroxylase) defines a novel cytochrome P-450
gene family. Proc Natl Acad Sci U S A. 83, 4243-4247.
First cattle CYP21A1 gene
CYP21A1 Bos taurus (cow)
See cattle page for details
MVLAGLLLLLTLLSGAHLLWGRWKLRNLHLP
234 PLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAG 413
414 RPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVD 563
564 QLTQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGNKEDTLVHAFHDCVQDLMKT 737
738 WDHWSIQILDMVPFLRFFPNPGLWRLKQAIENRDHMVEKQLTRHKESMVAGQWRD 902
903 MTDYMLQGVGRQRVEEGPGQLLEGHVHMSVVDLFIGGTETTASTLSWAVAFLLHHPEIQ 1079
1080 RRLQEELDRELGPGASCSRVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIF 1259
1260 GYDIPEGMVVIPNLQGAHLDETVWEQPHEFRPDRFLEPGANPSALAFGCGARVC 1421
1422 LGESLARLELFVVLLRLLQAFTLLPPPVGALPSLQPDPYCGVNLKVQPFQVRLQ 1583
PRGVEAGAWESASAQ*
CYP21A1 pig
S53049 M83939
MVLVWLLLLLTLLAGARLLWGQWKLRNLHLPPLVPGFLHLLQPNLPIYLLGLTQRLGPIY
RLRLGLQDVVVLNSKRTIEEALVRKWVDFAGRPQIPSYKLASQHCPDISLGDYSLFWKAH
KKLTRSALLLGVRSSMEPRVEQLTQEFCERMRAQAGTPVTIQKEFSVLTCSIICCLTFGD
KEDTLVHALHDCVQDLMKTWEHWSIQILDMVPFLRFFPSPGLRRLKQAIENRDHLVEKQL
RRHKESMVAGQWRDMLDYMLQEAGRQRVEEGQGQLLEGHVHMSVVDLFIGGTETTANTLS
WAVVYLLHHPEIQWRLQEELDRELGPGAAGSRVPYKDRARLPLLNATIAEVLRLRPVVPL
ALPHRATRPSSIFGYDIPEGTVVIPNLQGAHLDETVWEQPHEFRPDRFLAPGANPSALAF
GCGARVCLGEPLARLELFVVLVQLLQAFTLLPPEGALPSLQPHPHSGINLKVQPFQVRLQ
PRGGRGEGPGPR
CYP21 rat
GenEMBL U56853(1964bp)
Zhou,M.Y., Vila,M.C., Gomez-Sanchez,E.P. and Gomez-Sanchez,C.E.
Cloning of two alternatively spliced 21-hydroxylase cDNAs in the
rat adrenal.
unpublished (1996)
MLLPGLLLLLLLLLLAGTRWLWGQWKLWKLRLPPLAPGFLHFLQPNLPVYLFGLAQKLGP
IYRIRLGLQDVVVLNSNKTIEEALIQKWVDFAGRPQILDGKMNFDLSMGDYSLTWKAHKK
LSRSALVLGMRDSMEPLVEQLTQEFCERMRAQAGASVAIHKEFSLLTCSIISCLTFGDKQ
DSTLLNATHSCVRDLLKAWNHWSVQILDIIPFLRFFPNPGLWKLKQFQESRDHIVMQELK
RHKDSLVAGQWKDMIDYMLQGVEKQRDARDPGQLHERHVHMSVVDLFVGGTETTAATLSW
AVAFLLHHPEIQKRLQEELDLKLAPSSQLLYKNRMQLPLLMATIAEVLRLRPVVPMALPH
RATKASSISGYDIPKDTIIIPNIQGANLDEMVWELPSKFWPDRFLESGKSPRIPTFGCGA
RVCLGEPLARLEFFVVLARLLQTFTLLPPPDGTLPSLQPLPYTGINLLIPPFQVRLQPRN
LAPQDQGQK
CYP21 rat
GenEMBL U56854
alternatively spliced form
Cyp21 mouse
genEMBL AF049850 Mm.18845
MLLPGLLLLLLLLAGTRWLWGQWKLRKLHLPPLAPGFLHFLQPN
LPIYLLGLTQKLGPIYRIRLGMQ DVVVLNSNRTIEEALIQKWVDFAGRPHMLN GKMDL
DLSLGDYSLMWKAHKKLSRSALMLGMRDSMEPLIEQLTQEFCERMRAQAGTPVAIHKE
FSFLTCSIISCLTFGDKDSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLRFLPNPGL
QKLKQIQESRDHIVKQQLKRHKDSLVAGQWKDMIDYMLQGVEKQRDGKDEERLHEGHV
HMSVVDLFIGGTETTATTLSWAVAFLLHHPEIQKRLQEELDLKLGPGSQLLYRNRMQL
PLLMATIAEVLRLRPVVPLALPHRATRASSISGYDIPKDMVIIPNIQGANLDEMVWEL
PSKFWPDRFLEPGKNPRTPSFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPPDGT
LPSLQPQPYAGINLPIPPFQVRLQPRNLAPQDQGERP
Cyp21a2-ps mouse
GenEMBL AF030001
MLLPGLLLLLLLLAGTRWLWGQWKFRKLHLLPLAPGFLHFLQPNLPIYLLGLTQKLGPIYRIRLGLQ
Gap 30 aa missing
GKMDLDLSLGDYSLMWKAHKKLSRSALMLGMLDSMEPLIEQLTQEFCE
RMRAQAGTPVAIHKEFSFLTCSIISCLTFGDK
DSTLVQTLHDCVQDLLQAWNHWSIQILTIIPLLR
FFPNPGLQKLKQIQESRDHIIKQQLKQHK
DSLVAGQWKDMIDYMLQEVEKQRDGKDKEQLHEGHVHMSVVDLFIGGTETTATTLSWAVAFLLHHPE
IQK*LQEELDLKLGPGSQLLYRNRMQLPLLMATIAEVLHLRPVVPLALPHRATKAS
SISGYNIPKDMVIIPNIQGANLDEMVWELPSKFWP
DRFLEPGKNPRTPSFGCGARVCLGEPLARLELFVVLARLLQAFTLLPPPDGTLPSLQPQL
YAGINLLIPPFQVRLQPRNLAAQELGEKTLTG*
CYP21 pig
GenEMBL S53049 M83939 (4792bp) Swiss Q02390 (492 amino acids)
PIR S28169 (492 amino acids)
Burghelle-Mayeur,C., Geffrotin,C. and Vaiman,M.
Sequences of the swine 21-hydroxylase gene (Cyp21) and
a portion of the opposite-strand overlapping gene of unkown
function previously described in human.
Biochim. Biophys. Acta 1171, 153-161 (1992)
CYP21 sheep
PIR A43349 (497 amino acids) B43349 (479 amino acids)
Crawford, R.J., Hammond, V.E., Connell, J.M. and Coghlan, J.P.
The structure and activity of two cytochrome P450c21 proteins
encoded in the ovine adrenal cortex.
J. Biol. Chem. 267, 16212-16218 (1992)
B43349 is truncated early after alternate splicing
CYP21A1 Ovis aries (sheep)
M92836
Called P450C21C (intact functional)
MVLAGLLLLLLTLLAGAHLLWGRW
KLRNLHLPPLVPGFLHLLQPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMI
RKWVDFAGRPQIPSYKLVSQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVEQL
TQEFCERMRVQAGAPVTIQKEFSLLTCSIICYLTFGDKEDTLVHAFHDCVQDLMKTWDHW
SIQILDMVPFLRLFPNPGLWRLKKAIENRDHMVEKQLRRHKESMVAGQWRDMMDYMLQGV
GRQRVEEGPGQLLEGHVHMSVVDLFIGGTETKASTLSWAVAFLLHHPEIQRRLQEELDRE
LGPGASCSGVTYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVV
IPNLQGAHLDETVWEQPHEFRPDRFLEPGANTSALAFGCGARVCLGESLARLELFVVLLR
LLQAFTLLPPPGGALPSLQPDPYCGVNLKVQPFQVRLQPRGVEAGAWESTSAQ
CYP21A1_v1 Ovis aries (sheep)
M92837
Called P450C21D (truncated by alt. splicing, no activity)
MVLAGLLLLLLTLLAGAHLLWGRWKLRNLHLPPLVPGFLHLL
QPNLPIHLLSLTQKLGPVYRLRLGLQEVVVLNSKRTIEEAMIRKWVDFAGRPQIPSYKLV
SQRCQDISLGDYSLLWKAHKKLTRSALLLGTRSSMEPWVEQLTQEFCERMRVQAGAPVTI
QKEFSLLTCSIICYLTFGDKEDTLVHAFHDCVQDLMKTWDHWSIQILDMVPFLRLFPNPG
LWRLKKAIENRDHMVEKQLRRHKESMVAGQWRDMMDYMLQGVGRQRVEEGPGQLLEGHVH
MSVVDLFIGGTETKASTLSWAVAFLLHHPEIQRRLQEELDRELGPGASCSGVTYKDRARL
PLLNATIAEVLRLRPVVPLALPHRTTRPSSIFGYDIPEGMVVIPNLQGAHLDETVWEQPH
EFRPDRFLEPGANTSALAFGCGARVCLGESLARLELFVVLLRLLQAFTLLPPPGGALPSL
QPDPYCGVNLKVQPFQD
CYP21A1 Gallus gallus (chicken)
NM_001099358
43% to CYP21A2 human, 45% to 21A1 cattle
between CENPA and TNXB, not in the genome assembly
MAVTILLLLLLLALIWGGSARRGGAPWGGALHLLHPGGPRHLHI
LARTYGDPLCLRLGGCEVVVLSSAAAIREALARRWGDFVGRPHSYLASLVSRGGQDLA
LGDASPEWRRQRGATRGALARAVRHLEPLLELQGWALCQELSSYGAAPVDLFEAFTFH
TCSTICRLAFGDLMPPEAEVRSFTRCVVELLEVWGRASVRALDVLPSLRVLPNAGLRE
LLRLVERRDAFVESQIRWHQVGNVGTQGCASPPRDTVLGALLGGDPTVPMGPLGGDRL
HMALVDLFIGGTETTAVALLWAVAFLLHHPQVQDQVRAELRQVLGPRGTPKPGDMGRL
PLLRATVTETLRLRPPAPLALPHCARRHSSIAGIPVPAGSIVIPNLFAAHHDPKIWDR
PDEFLPERFLQPGAPWRALLPFGCGARSCVGEALARAELFVFLGHILQRFRLEPPSDG
ALPHLGVTAGTVLRCAPFRVRLTPCPPP
CYP21A1P Gallus gallus (chicken)
This gene is next to C4 as in humans = pseudogene
DMGRLPLLRATVTETLRLRPPAPLALPHCARRH &
SIAGIPVPAGSIVIPNLFAAHHDPKIWDRPDEFLP
ERFLQPGAPWRALLPFGCGARSCVGEALARAELFVFLGHILQRFRLEPPSDGALPHLG
VTAGTVLRCAPFRVRLTPCPPP*
CYP21A1P Taeniopygia guttata (zebrafinch)
Ensemble peptide ENSTGUP00000003346_part
This is the first bird CYP21 found
QLQARLRAELEGAQGPPGPGDMGRLPLLQATVSETLRLRPPAPLALPHCALRHTSLGGLP
VVAGTVLVPNLLAAQQDPDIWQHPEVFLPERFLAPGTPSRSLLPFGCGARSCPGEGLARA
EIFEFLGLILREFRLEPGPGGLPGLKGSPGTVLRCPPFRLRMVPCQPL
CYP21A1P Taeniopygia guttata (zebrafinch)
XM_002191753
LQARLRAELEGAQGPPGPGDMGRLPLLQATVSET
LRLRPPAPLALPHCALRHTSLGGLPVVAGTVLVPNLLAAQQDPDIWQHPEVFLPERFL
APGTPSRSLLPFGCGARSCPGEGLARAEIFEFLGLILREFRLEPGPGGLPGLKGSPGT
VLRCPPFRLRMVPCQPLGSP*
CYP21A1 Anolis carolinensis (green anole lizard)
Ensemble peptide ENSACAP00000013728
45% to CYP21A2 human
44% to CYP21A1 chicken, between CENPA and TNXB
MLSALLFVVVLLAIALLSRWHPWHCQGKDAKDLPGPRALPLIGNLSHMFQPNLPIHFLQ
LAHRYGPIYRLRLGNKDVVVLNSLETIREALIRKWSDFAGRPHSFIT
NLISMGGKDLSLGDYTPTWRLQRKLTHMAFQRCRQGDMEQIVHSQAQHLCKVFRSYGGEP
VDVAHDFSMHACSVISTMLFGPLDMPSIEKMHDCMLEMVKAWNALPIRVLDFWPILKIFP
NPSLRHLLSCLENRDDVVQGQMAKHQKSDHSPEEQDMLDHMLHFLHDHDIKKWGDTGLLP
DHVHMAVVDLVTGGTETTATLLTWAVAFLLHCPQIQELIHKELMTVVGPHRDPTYSDREH
LPYLNATIWEALRMRPSAPLALPHMTIRDTSVAGFSIPKGTTVIPNLYGAHQDPSKWPNP
QEFRPGQALAEAQRHLVPFSCGARVCLGEALARMEAFLFLAYILRDFQILPSPSGSLPDL
QPHCEFLMFCKPFMARLVPWVENGSAE*
CYP21A1 Xenopus tropicalis (Western clawed frog)
50686_prot scaffold_1026:150552-153289
50687_prot
41% to human CYP21A2,
45% to Fugu CYP21, 46% to zebrafish CYP21
MALLLLLLLFLVLLSLQWAKKYFLGFSNPHVHYPPCPPPLPFLGNLLHLA
HKDLPIHLLHLSRKYGSIYRLSFWGKDFVVLNNSNLIREALLKKWADFAG
RPKSYIGDLISLGGKDLSLGDYTPVWKVQRRLTHTSLQNCVRNDLENVLI
REARLLCQDCLNLNGEPVDISRSFSLRTCRIIAELTFGTTYDLSDPKFQE
IHKCIVNIIKLWESPSVTALDFIPFLQ (0)
KFPNQTLKLLMDTAKQRDSFIKSQVEAHKAHLPSSKCDEDILDGMMRFLL
EKSGDDSSGMSEFSEDHLHMAVVDLFIGGTETTASLLTWTVAYLMHYPEA
QDKIHQEIIGAVGMERYATYTDRNSLPYLNATVSEMLRLRPVVPLAVPHC
TIRDTSIAGYTIPKGTTVIPNIYAAHLDETIWDNPTQFYPENSHSSRALL
PFSVGARLCIGETLARMEVFFFLSHLLRDFRLLPPSPELLPELSGVFGIN
FKCRPFLVCISPRENTPKIQDLNNKT*
CYP21A1 Xenopus laevis (African clawed frog)
SwissProt Q6AX26 85% to X. tropicalis
This seq is missing N-term
note: X. tropicalis is missing PERF motif = PENS
CF521371.1
DAWVALLLLILLFLGLLSLQWAKKYFQGFSNPHVHYPPCPPPLPFLGNLFHLAHKDLPIH
LLHLSKKYGPIYRLSFWGKDFVVLNSSDLIREALLKKWADFAGRPQSYIGDLISLGGKDL
SLGDYTPVWKVQRRLTHTSLQNC
MRNDLEKVLIREARLLCQDCLDLNGEPVDISRSFSLRTCRIIAELTFGTTYDFTDPDFQK
IHKCIIDIIKLWESPSVTALDFIPFLQKFPNQTLNLLLETAKQRDSFIKSQVEAHKAHLP
SSKYNEDILDGMIRLIREKSGDDSNGMSEFSEDHLHMAVVDLFIGGTETTASLLTWTVAY
LMHYPEAQERIHQEITGAVGTERYPTYTDRNRMPYLNATISEMLRLRPVVPLAVPHCTIK
DTSIAGYTIPKGTTVIPNIYAAHLDETIWDNAAQFCPDRFLSPSESSNSARALLPFSVGA
RLCIGETLARMEVFFFLSHLLRDYRLLSPSPKLLPQLSGMFGINLKCHPFMVCISPRENT
PKILDFNKET
CYP21A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP21A1 Fugu rubripes (pufferfish)
Scaffold_15 complete gene 11 exons
= LDZ12559.x1 LPC12755.x1
revised seq. changed N-term
42% to CYP21 human over 455 amino acids
this is the first fish CYP21 sequence found
MSVEVLAAIGAAALLVLLLMLLRDKCVKKYHEE (1)
TVKRNLPLSLWQLPLRPSSPPIPGPPCRFLIGNMTE
28230 LMHDHLPIHLTNLAKRYGNIYRLKCGNTT 28144 (1)
28058 AMIVLNSSDIIREALVKKWSDFAGRAVSYT 27969 (1)
27888 ADIVSGGGRNISLGDYTEEWKALRRLVHGALQRCCKHSLHNVIERQALQLRK 27754 (0)
VLVDYRGGAVDLSEDFTVAASNVIITLVFGKE (0)
YDKSSSELQQLHRCLNEIVALWGSTWISALDTFPLLR (0)
KFPNPVFSRLLREVSRRDEIIRKHLNQFK (0)
SEGHRRTDVITGSLLEG (0)
26896 VLTDMHVHMATVDLLIGGSETTAAWLNWTVAFLLHRPE (0)
FQTKVYEELCTVLEGRYPKYSDRQRLPILCSLIHEVLRLRPVAPLAVPHKAIRDS (2)
SIAGYFIPRNTIIIPNLFGAHHDPEVWSDPYSFKP (1)
26238 ERFLEGGGGSTRALIPFGGGARLCLGETVAKMELFLFTAYLLRDFCFVLPDSEAPLPDLR 26059
26058 GVASVVLKIKSFTVIARPRTGP* 25990
CYP21A1 Tetraodon nigroviridis (Green puffer)
GenEMBL AL281449.1 C0BG094DE12LP1 G Tetraodon nigroviridis
genomic clone 094J24 T7.Length = 895
AL233853.1 C0BG007BE04XD1 G Tetraodon nigroviridis
genomic clone 007I08 T7.Length = 1079
88% to CYP21A1 fugu
N-term similar to Micropogonias undulatus EU673090
MSVEVLVAGVGAGFLLVLLLMVLKDMCVKKNHNE (1)
TVKRSLLQSLCGLLHRPSSPSIPGPPCRFLIGNMTELMQDHLPIHLTDLAKRYGNIYRLKCGNT (1)
TMVVLSSGDVIREALVKKWSDFAGRSVSYT (1)
ADIVSGGGRTISLGDYTEEWKAHRRLVHSALQRCCKQSLHDVIERQALQLRK (0)
VLINYQGGAVDLSEDFTVAASNVITTLVFGKE (0)
YDKSCSELQQLHSCLNEIVALWGSAWISALDTFPLLR (0)
KFPNPVFSRLLREVTRRDEIIRKHLNQYK (0)
SQDNKSTDVITGSLLEG (0)
VLTDVHVHMATVDLLIGGTETTAAWLNWTVAFLLHRPE (0)
IQTKVYEELCTVLEGRYPKYSDRHRLPVLCSLVHEVLRLRPVAPLAVPHKAVRDSS (2)
IAGYFIPKNTIIIPNLFGAHHDPAVWPDPYSFKP (1)
ERFLEGGGGSPRALVPFGGGARLCLGETVAKMELFLFTAYLLRDFCFCLPDVEAALPDLR
GVASVVLKVKAFTVVARPRIRPLSSGSVPLV*
CYP21A1 Oncorhynchus mykiss (rainbow trout)
EU246942
WDLSEDFTVAASNVITTLAFGKEYEKSSAELQRLHGCLNEIVSL
WGSPWISALDSFPLLRKLPNPPFSRLLKEVARRDDIIRTHLDEYKMQAPSKTSEEAIA
ITSALLNGLGKPQDTTQGVVLTDTHVHMATVDLLIGGTETTAAWLSWTVAFLLH
22A Subfamily
CYP22A1 Caenorhabditis elegans (nematode worm)
GenEMBL U39648 (28581 bp) AF407572, NM_171699, NM_171698
cosmid T13C5.1
Jia,K., Albert,P.S. and Riddle,D.L.
DAF-9, a cytochrome P450 regulating C. elegans larval development
and adult longevity
Development 129 (1), 221-231 (2002)
daf-9 mutant This gene may be in the pathway to
synthesize a ligand for DAF-12, a nuclear receptor.
Daf-9 has a role in larval development.
DAF comes from abnormal DAuer Formation
CYP22A1 Caenorhabditis briggsae ortholog
XP_002644834.1 77% to CYP22A1
MQMSNSLYIQIRDWVAFVVSHHVIMAMYFVLSY
SVIPYFVPSVFWEKCFIRFFIVHLFLVVFLHYQRVTKYPPGPPPMAILGNSPFINVLSPE
KTFLEYREIYGPVFTLHLS
QPTVILADYKSIEEALVAN
GQKTSGRSSAESFVLFTGDRQDGDGVILAMRQKWKNMRQEILRFMSKWYGKP
MDELVLHHTRSLESELVKMAESK
CLIDLREPISGAIANVIQQITIGRNYLYQDTEFQAQLKDINAVVKE
IMTAEVFFVNCYPFLRFLPEGILRKWTNYKRSGFRLQQW
FRTILDEHHINRHQGDFMSHMVDLQESRPDEFN
DLSIILTCGDMWTGGMETTTTTLRWGIIYLLNNPEVQTKCHNELVKVFGTDEPEMSKMNQTPYVRAT
LSEIQRLANVLPWAIPHK
TFEECQVGEHKIPVNTEVIPALGALLCDPTLFENPKEFKPERFLDKEGKYYVMEEFRPF
GMGPRVCLGERVARTELYLIFASLLQNFRFYLNR
TDPIPVAERIIGGITAPPKPYSTRVEYHGQRIVH*
CYP22A2 Caenorhabditis briggsae
XP_002635784.1
MRISRSTEIQIRDWCYFAISHLAIISFYYMLMLIPVISISPLCFFA
AIALHLAYFVRQHRYYATEYPPGPPPMAIFGNGVSVNTRAPEKTFLEYRAIYGPVFTLHLSQPTVILADY
DSIHEALIHNGQKTSGRSNSESFVLFTGDRNHGDGVILSSGQKSKNMRQETQKFLRNWPGKRMDNLVLHH
TASLEAALIKQAESKGLSDIKDPISGAIANIIQQMTIGRNYEYQDAEFQTQLSNINAVVKELMTFGVFFV
NSFPISRFLLQWLPSSWMAYKNSGFKLQQWFRDILNEHKVNRHQDDFMSHMLDLQETRPEEFKDLSIILN
CGDMWTGGMETTTTTLRWGLIYLLQNPEVQAKCHQEIISAFGNDAPETSKMHLTPYVRATLSEIQRLANV
LPWAIPHKSFEDCQIGGYKIPANTEIVPALGALLCDPTVFKNPEEFKPERFLDQYGEYSPMEEFRPFGMG
PRACLGEKLARTELYLIFSSLVQNFRFYLNESDPKPTTERVTGGITAPPMPYSTRVEYIGNRQVYY
23A Subfamily
CYP23A1 Caenorhabditis elegans (nematode worm)
GenEMBL U39472 (42282 bp)
see CYP14A1 for reference
cosmid B0304.3
CYP23A1 Caenorhabditis briggsae ortholog
XP_002630091.1 86% to CYP23A1
MPSIKYAILLSVVTSFLYFRIMKSFEMDSYT
TTYIYLFFCTISYIFYESNYKRRRLPNGPMPWLVAGNMPSFIN
VKNVDDLFLYWKQRYGGIFTVWIGPIPLVM
VSDLPTIKKYFIQHADAFSNRWRNFVTDSIM
EGSNGIVQIDGDKWREQRRFALHTLRDFGVGRPLMEQMITLE
VTTLMNHMAKSCGLSTKEVNLCPSIAVCVGNIINNMLFGLRFNQDNSYMHRLHSLLDDQ SHTVMQPIMGAYIAFPVTTKVPFINGEWNRLMGIKKELLEFLEGQIQKHRENWKEEMMEQ EPEDLTYAYMIEVEKRKRAGEDVGFFD
DQQLKMLLLDLFFAGMETTVTTLKWAFLLMSKNPRVQRKVQEELDSIAQPMVEIQHRTRL PYIQATINEIQRIANILPINLLRTVAEDIDIDGYQFKKGDLTIPQISILMNDPEIFKNPK DFCPERFLDENLNVKKIDEFLPFSIGRRQCLGESLARAELYLIFANLMQNFKFEVSEDVTTE
RVLGLTVSPVQYTCKISRRGLDHNENCVK
24A Subfamily
CYP24 rat
GenEMBL L04608 to L04619, S52625 to S52636
Ohyama,Y., Noshiro,M., Eggertsen,G., Gotoh,O., Kato,Y.,
Bjorkhem,I. and Okuda,K.
Structural characterization of the gene encoding rat
25-hydroxyvitamin D3 24-hydroxylase.
Biochemistry 32, 76-82 (1993)
CYP24 rat
GenEMBL Z28351 (1419bp)
Hahn,C.N., Kerry,D.M., Omdahl,J.L. and May,B.K.
Identification of a vitamin D responsive element in the promoter of
the
gene for the rat 25-hydroxyvitamin D3 24-hydroxylase
Nuc. Acids Res. 22, 2410-2416 (1994)
CYP24 rat
GenEMBL X59506 (3209bp)
Ohyama,Y., Noshiro,M. and Okuda,K.
Cloning and expression of cDNA encoding 25-hydroxyvitamin D3 24-
hydroxylase.
FEBS Lett. 278, 195-198 (1991)
CYP24 rat
GenEMBL D17792 (?bp)
Ohyama, Y., Ozono,K., Uchida,M., Shinki,T., Kato,S., Suda,T.,
Yamamoto,O.,
Noshiro,M. and Kato,Y.
Identification of a vitamin D-responsive element in the 5'-flanking
region of the rat
25-hydroxyvitamin D3 24-hydroxylase gene.
J. Biol. Chem. 269, 10545-10550 (1994)
CYP24 rat
GenEMBL U03112 (?bp)
Zierold,C., Darwish,H.M. and DeLuca,H.F.
Identification of a vitamin D-response element in the rat calcidiol
(25-hydroxyvitamin D3) 24-hydroxylase gene.
Proc. Natl. Acad.Sci. USA 91, 900-902 (1994)
CYP24 human
GenEMBL S67623 (776bp)
Labuda,M., Lemieux,N., Tihy,F., Prinster,C. and Glorieux,F.H.
Human 25-hydroxyvitamin D 24-hydroxylase cytochrome P450
subunit maps to a different chromosomal location than that of
pseudovitamin D-deficient rickets.
J. Bone Miner. Res. 8, 1397-1406 (1993)
CYP24 human
GenEMBL L13286 (3254bp)
Chen,K.-S., Prahl,J.M. and DeLuca,H.F.
Isolation and expression of 1,25-dihydroxyvitamin D3
24-hydroxylase cDNA.
Proc. Natl. Acad. Sci. USA 90, 4543-4547 (1993)
CYP24 human
NM_000782
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVC
PLTAGGETQNAAALPGPTSWPLLASLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLG
SFESVHLGSPCLLEALYRTESVPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSA
FQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVL
YEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQGHTLAWDT
IFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSL
MWILYNLSRNPQVQQKLLKEIQSVLPENQRPREEDLRNMPYLKACLKESMRLTPGVPF
TTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFA
HLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPI
AFCQR
CYP24A1 Pan troglodytes (chimpanzee)
XM_001154704 end in a seq gap
96% to CYP24A1 human
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVC PLTTGGETQNAAALPGPTRWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLG SFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYREEGYGLLILEGEDWQRVRS AFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHIEDLYSELNKWSKESICLV LYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWD TIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANS LMWILYNLSHNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSIP
FTTRTLDKATVLGEYALPKG
CYP24A1 Bos taurus (cow)
See cattle page for details
6035 MSSPISKSRSLAAFLQQLRSLGQPPRPVTSTACSPRRPREVPLCPVMEPGEAQDAATLP 6211
6212 GPTKWPLLGSLLEILWKGGLKKQHDTL (0)
6511 VEYHKKYGKIFRMKLGSFDSVHLGSPCLLEALYRTESAHPQRLEIKPWKAYRDYREEGYGLLIL(2) 6702
7484 EGEDWQRVRSAFPKKLMKPVEIMKLDDKINE(0) 7573
4559 VLADFMGRIDELCDERGRIEDLYTELNKWSFE (1)
2100 SICLVLYEKRFGLLQKNAGEEALNFIMAVKT (0)
1035 MMSMFGKMMVTPVELHRSLNTRVWQAHTQAWDTIFRS (1) 925
1303 VKSCVDNRLEKYSEQPSMDFLCDIYHHNQLSKKELYAAVTELQLAAVET (0) 1449
TANSLMWILYNLSRNPHVQQKLFKEIQSVLPENQLPRAEDLRNMPYLKACLKESMR
LNPTVPFTTRTLDKAMVLGEYALPKG
5393 TVLVLNTHVLGSSEENFEESSQFRPERWLQDKKNLNPFAHLPFGVGKRMCVGRRLAELQL 5572
5573 HLALCW (0) 5602
IVRKYDVVATDLEPVETLHLGNLVPGRQLPVAFCQR
CYP24A1 pig
NM_214075
MSSPISKSGSLAALLQQLRSCGQPPRPVTSTACVPRRSKEVPLC
PMEQPGETQDAAXAGSTRWPLLGSLLEILWKGGLKKQHDTLAEYHRKYGKIFRMKLGS
FDSVHLGSPCLLEALYRTESAHPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSA
FQKKLMKPMEVMKLDNKINEVLADFMSRIDELCDERGCIEDLYSELNKWSFESICLVL
YEKRFGLLQKNAGEEALNFITAIKTMMSTFGKMMVTPVELHKNLNTKVWQAHTLAWDT
IFKSVKSCIDHRLEKYAEQPSADFLCDIYHHNQLSKKELYASVTELQLAAIETTANSL
MWILYNLSRNPHVQQKLLKEIQSVLPENQMPRAEDLRNMPYLKACLKESMRLTPSVPF
TTRTLDKAMVLGEYALPKGTVLMLNTYVLGTNEENFEDSSQFRPERWLQEKKKINPFA
HLPFGVGKRMCIGRRLAELQLHLALCRIIRKYAIVATDSEPVGMLHLGILDPTRQLPI
AFCQR
CYP24A1 Ovis aries (sheep)
EF635857 (partial)
INEVLADFMGRIDELCDERGRIEDLYTELNKWSFESICLVLYEK
RFGLLQKKAGEEALNFIMAIKTMMSTFG
CYP24A1 Canis familiaris (dog)
XM_543059.2
88% to CYP24A1 human
MSCPIAKSRSLVALLQQLGHLGQPPRPVASAACAPPRPREVPLC
PPVEPGEAQNAAALRGPTNWPLLGSLLEILWKGGLKKQHDTLAEYHKKYGKIFRMKLG
SFDSVHLGSPCLLEALYRTESAHPQRLEIKPWKAYRDYREEGYGLLILEGEDWQRVRS
AFQKKLMKPVEIMKLDNKINEVLADFMGRIDELCDERGRIEDLYSELNKWSFESICLV
LYEKRFGLLRKNAGDEALNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQAHTLAWD
TIFKSVKSCIDNRLEKYSEQPSTDFLCDIYHHNQLSKKELYAAVTELQLAAVETTANS
LMWILYNLSRNPHVQQKLLKEIQRVLPENQMPRAEDLRNMPYLKACLKESMRLTPSVP
FTTRTLDKETVLGEYALPKGTVLMLNTQVLGSNEENFKDSSQFRPERWLQEKKKINPF
AHLPFGIGKRMCIGRRLAELQLHLALCWIIRKYDIVATDHEPVEMLHLGILVPSRELP
IAFRQR
Cyp24 mouse
GenEMBL D89669, AC084066.1, Mm.6575
MSCPIDKRRPLIAFLRRLRDLGQPPRSVTSKAHVKRAPKEVPLC
PLMTDGETRNVTSLPGPTNWPLLGSLLEIFWKGGLKKQHDTLAEYHKKYGQIFRMKLG
SFDSVHLGSPSLLEALYRTESAHPQRLEIKPWKAYRDHRNEAYGLMILEGQEWQRVRS
AFQKKLMKPVEIMKLDKKINEVLADFMGQIDELRDERGRIQDLYSELNKWSFESICLV
LYEKRFGLLQKDTEEEALTFIAAIKTMMSTFGKMMVTPVELHKRLNTKVWQAHTLAWD
TIFKSVKPCIDHRLERYSQQPGADFLCDIYQQDHLSKKELYAAVTELQLAAVETTANS
LMWILYNLSRNPQVQQRLLREIQSVLPDNQTPRAEDVRNMPYLKACLKESMRLTPSVP
FTTRTLDKPTVLGEYTLPKGTVLTLNTQVLGSSEDNFEDADKFRPERWLEKEKKINPF
AHLPFGVGKRMCIGRRLAELQLHLALCWIIQKYNIVATDSEPVEMLHLGILVPSRELP
IAFCPR
CYP24A1 Gallus gallus (chicken)
NM_204979
MGGCSILLRSSALTCGRPRSSPPGAEVRCRGRRPLCALRGRGHP
LAALPGPPSWPLMGSLPDVLWKGGLKRQHETLAEYHRRFGKIFRMKLGAFDSVHIGAP
CLLESLYRRESSCPQRLEIKPWKAYRDYRDEGYGLLILEGKDWQRVRSAFQKKLMKPK
EVVKLDNTINEVLEDFMHRIDEICNHNGQMEDVYSEFNKWSFESICLVLYGKRFGLLQ
QDVEEESLNFIKAVKTMMATFGMMMVTPVELHKGLNTKVWQAHTKAWDDIFKTAKHSI
DSRLQRHSANPQEDFLCDIYSGGQLSKKELYATIAELQIAGVETTANSLLWALYNISR
NPHVQQKLLQEIQSVLAANESPTAESIKNMPYLKACLKESMRLTPSVPFTTRTIDTEM
VLGDYVLPEGTVLMINSYALGCNEEYFNGWTQFKPERRWLQKHSINPFSHVPFGIGKR
MCIGRRLAELQLHLALCWIIRKYQLVATDDNPVETLHSGILIPSRELPIAFHRRLQLD
CYP24A1 Xenopus tropicalis (Western clawed frog)
DT404490 Cannot extend in ESTdb
26514_prot scaffold_125:1595529-1618234 UCSC browser (errors in model)
67% to CYP24A1 human
MTSRIKRDFLGMLLKSRSISVQHSIPTATAVCDLKEKELPAPSSCPHSLA
ALPGPTKLPILGSLLDILRKGGLKRQHEALASYHKQFGKIFRMKLGSFDS
VHIGAPCLLEALYREESNYPKRLEIKPWKAYRDYRDEAYGLLILEGKDWQ
RVRSAFQQKLMKPTEVGKLDTKINEVLVDFMKRIDSVCDEDGT
IEDLYCELNKWSLESICLVLYEKRFGFLQPNLGEEAQNFITAIKM
MMSTFGLMMVTPVELHKSLNTKIWK
DHTHAWDSIFKTAKCHIDRRLTKLSSKGSEDFLCTIYNDSKLSKKEMYAT
ITEMLIGAVETTANSLLWAIFNISRNPHIQKKLLEEIESVLLPDQVPTAD
DIRNMPYLKACLKESMRITPSIPFTTRTLDKETVLGDYVLPKGTVLTINS
HVLGSNQECFDNWNQFRPERWLQQKNTINPFAHVPFGIGKRMCIGRRLAE
LQLQLTLCW (0)
LIRKYEIVATDNDPVETLHLGTLMPSRELPVAFHRR*
CYP24A1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP24 Fugu rubripes (pufferfish)
No accession number
Scaffold_4128
MLWRLRGALTLPPELTVLDAIPGPTNWPLVGSLFELLRKGGLTRQHEAL
VDYHKKFGKIFRLKLGSFESVHIGAPCLLESLYRTEGSYPQRLEIKPWTAYRDMRDEAYGLLIL
EGKDWQRVRRAFQQKLMKPTEVVKLDRKINE
VLEDFVSRIGKTNIGGKIEDLYFELNKWSFES
ICLVLYDKRFGLLQDKVNEEAMNFITAVKT
MMSTFGLMMVTPVELHKSLNTKTWQDHTAAWDRIFST
AKVYIDKKLKRNSVIAPDDLIGDILHQSRLSKKELYAAITELQIGGVET
8608 TANSMLWAIFNLSRNPGAQRRLLEEIRTVVPPEQDPCGEHIKSMPYLKACLKESMR 8441 (2)
7830 ISPSVPFTSRTLDKDTVLGDYAIPKG 7753
TVLMINSHALGSSEDYFDDGKKFKPERWLREHGTINPFAH
VPFGIGKRMCIGRRLAELQMSLFLQLVRDFE
IVATDNEPLDVIHSGLLVPNRELPVAFIKR
CYP24A1 Tetraodon nigroviridis (Green puffer)
95% to fugu CYP24A1
MRAQMKKAPQFVELLRKKSVGLQHFKPTSSVCVLEEKDAVEAAPCP
HAASRAHSLDAIPGPTNWPLVGSLIELLRKGGLTRQHEAL (0)
VDYHKKFGKIFRLKLGSFESVHIGAPCLLESLYRTEGSYPQRLEIKPWTAYRDMRDEAYGLLIL (2)
EGKDWQRVRRAFQQKLMKPTEVVKLDRKINE (0)
VLGDFVGRIGKTNVSGKIEDLYFELNKWSFE (1)
TICLVLYDKRFGLLQDKVNEEAMNFITAVKT (0)
MMSTFGMMMVTPVELHKSLNTKTWQDHTAAWDRIFST ()
AKVYIDKKLKRNSVIAPDDLIGDILHQSRLSKKELYAAITELQIGGVET (1)
TANSMLWAIFNLSRNPDAQRRLLEEIRTVVPLDQDPCGEHIKSMPYLKACLKESMR (2)
ISPSVPFTSRTLDKDTVLGDYAIPKG (0)
TVLMINSHALGSNEDYFDDSKKFKPERWLREHGTINPFAHVPFGIGKRMCIGRRLAELQLQLAMCW (0)
LVRDFEIVATDNEPLDVIHSGLLVPNRELPVAFIKR*
CYP24A1 Oncorhynchus mykiss (rainbow trout)
AY526907
EIKPWKAYRDFRDEAYGLLILEGKDWQRVRSAFQQKFMKPTEVA
KLDGKINQVLSDFVSRIGQVTDNGRFEDLYFELNKWSMETICLVLYDKRFGLLHDNVN
EEAMTFIMSIKTMMSTFGMMMV
25A Subfamily
CYP25A1 Caenorhabditis elegans (nematode worm)
GenEMBL Z66495 ( 40145bp)
see CYP14A1 for reference
cosmid C36A4.1
CYP25A2 Caenorhabditis elegans (nematode worm)
GenEMBL Z66495 ( 40145bp)
see CYP14A1 for reference
cosmid C36A4.2
CYP25A3 Caenorhabditis elegans (nematode worm)
GenEMBL Z66495 ( 40145bp)
see CYP14A1 for reference
cosmid C36A4.3
CYP25A4 Caenorhabditis elegans (nematode worm)
GenEMBL Z66495 ( 40145bp)
see CYP14A1 for reference
cosmid C36A4.6
CYP25A5 Caenorhabditis elegans (nematode worm)
GenEMBL AF038613
see CYP14A1 for reference
F42A6
CYP25A6P Caenorhabditis elegans (nematode worm)
GenEMBL U50072
K06B9.1
missing C-terminal
CYP25A7 Caenorhabditis briggsae
XP_002641045.1 III - 2035411-2049578
MALLILSTIFVILLSFIVYILIARRERFKLREKIGLSGPEPHWFLGNLKEIVE
RKEKLGYDDSNEWFNVLHKQYGETFG
IYFGAQMNIVLSNEEDI
KEVFIKNFSNFSDRIVPPIFTENNLNSSLLQNTYATGWKHTRSTIAPIFSTGKMKAMHETISSKIDTLLE
ILEEKSMGNEQWDIYDFQGLTLDVIGKCAFAIDTNCQRDRNDVFYVNARKFIQNIDIRHSKVISSSFILP
ELSWLWRWMYKYTALAAAEIPLVQGLEDVYERR
RSGEGSDSVDLLKLLLDREDDKTKEKMTKKEVIENCF
AFLLAGYETTSTAMTYCSYLLAKYPEIQKKLWQEIKLVKNEGTLDYDSIHSMKYLDAVYKETLRYYPPVI
HFINRVCLSDIVIRGQLYPKGSVVIAQPNTIHRSESNWEHPGIFDPDRFLAENSKLEKSSNLKWIPFGVG
PRYCVGMRFAEMEFKMTIAKLIDKFELGIPMGEPDLIPENNGIILRPKDPVRLNLKLR
CYP25A8 Caenorhabditis briggsae
XP_002641046.1
III + 2052466-2056810
MTLLILSTLLIAILTFIFHSIFVRIQKFKLRAKIGLGGPPPHWLLGNLKDIID
RTKDIGWNNAQEWHLELQRKYGDRYA
IYFGQKLDIFLCNEEDIKEVFIKNFSNFSDRGVIEIFRETKLNASLLQNTYKNGWKHTRST
IAPIFSTGKMKAMHETISSKIDTLLEILEEKSMGNEQWDIYDDFQGLTLDVIGKCAFAIDTNCQRDRNDV
FYVEARNFFKNIDLRHNPLVTCSVMIPELMWIWKFLYKFSGLAEAEIPLVQGLEDVYERR
RSGEGSDSVD
LLKLLLDREDDKTKEKMTKKEVIENCFAFLLAGYETTSTAMTYCSYLLAKYPEIQKKLWQEIKLVKNEGT
LDYDSIHSMKYLDAVYKEALRYYPPVIHFISRTCLSDITIRGQFYPKGCSVTVQGNTIHRSESNWDHPDI
FDPDRFLAENSEATEKSTNLKWIPFGVGPRFCVGMRFAEMEFKMTIAKLIDKFELGIPMGEMDLIPDCNG
VIMRPKDAVRLNLKLRK
26A Subfamily
Cyp26a1 mouse
No accession number
Jim Ray
submitted to nomenclature committee
Note: new family in mammals, homolog to human ESTs R51129 and R21282
Cyp26a1 mouse
No accession number
Martin Petkovich
submitted to nomenclature committee
Note: new family in mammals, homolog to human ESTs R51129 and R21282
Cyp26a1 mouse
GenEMBL Y12657
Fujii, H., Sato, T., Kaneko, S., Gotoh, O., Fujii-Kiriyama, Y.,
Osawa, K.,
Kato, S. and Hamada, H.
Metabolic inactivation of retinoic acid by a novel P450
differentially expressed in
developing mouse embryos.
EMBO J. 16, 4163-4173 (1997)
Note: new family in mammals, homolog to human ESTs R51129 and R21282
Cyp26a1 mouse
GenEMBL Y12657 NM_007811 EST AA239785
no UNIGENE entry
MGLPALLASALCTFVLPLLLFLAALKLWDLYCVSSRDRSCALPL
PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
GEHRLVSVHWPASVRTILGAGCLSNLHDSSHKQRKKVIMQAFSREALQCYVLVIAEEV
SSCLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPGPAGGGEDEQQLVEAFEEMT
RNLFSLPIDVPFSGLYRGVKARNLIHARIEENIRAKIRRLQATEPDGGCKDALQLLIE
HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREEIKSKG
LLCKSNQDNKLDMETLEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
NVIYSICDTHDVADIFTNKEEFNPDRFIVPHPEDASRFSFIPFGGGLRSCVGKEFAKI
LLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTYFQGDI
Cyp26a1 rat
CYP26A1 human
GenEMBL NM_000783
White,J.A., Beckett-Jones,B., Guo,Y.D., Dilworth,F.J., Bonasoro,J.,
Jones,G. and Petkovich,M.
cDNA cloning of human retinoic acid-metabolizing enzyme (hP450RAI)
identifies a novel family of cytochromes P450
J. Biol. Chem. 272 (30), 18538-18541 (1997)
Note: new family in mammals, equal to human ESTs R51129 and R21282
CYP26A1 human
NM_000783
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPL
PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
GDDRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEV
GSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT
RNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIE
HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKG
LLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
NVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKI
LLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
CYP26A1 Pan troglodytes (chimp)
XM_001147866.1 3 aa diffs to human
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPL PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL GEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEV GSSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMT RNLFSLPIDVPFSGLYRGMKARNLIHARIEQNIRAKICGLRTSEAGQGCKDALQLLIE HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKG LLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW NVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKI LLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDNLPARFTHFHGEI
CYP26A1 Bos taurus (cow)
See cattle page for details
MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSSRDRSCALPL
PPGTMGFPFFGETLQMVLQREKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
GEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKK (0)
VIMQAFSREALQCYVPVIAEEVGNYLEQWLSCGERGLLVYPQVKRLMFRIAMRILLGCE
SRLASGGEDEQQLVEAFEEMTRNLFSLPIDVPFSGLYR
GLKARDLIHARIEENIRAKIRRLPAAEAGGGCKDALQLLIEHSWERGERLDMQ
ALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKNK
GLLCKGNQDNKLDVEI
LEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVADIFT 182
183 NKEEFNPDRFLLPHPEDASRFSFIPFGG
GLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTVYPVDDLPARFTRFQGEI* 449
CYP26A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
92% to human 26A1, full seq. constructed from ESTs
Ortholog of human CYP26A1
CYP26A1 Sus scrofa (pig)
Pig ESTs CN161524.1, CN162920.1, CF179212.1, DY434075.1,
CF180567.1, CN165481.1,
93% to human 26A1
MGLPALLASVLCTFVLPLLLFLAAIKLWDLYCVSSRDRSCTLPLPPGTM
GFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVS
VHWPASVRTILGSGCLSNL
HDSSHKQRKKVITQAFSREALQCYVPVIAEEVDSCLEQWLSCGERGLLVYPQVKR LMFRI
AMRILLGCEPRLASGGEAEQQLVEAFEEMTRNLFSLPIDVPSSGLYRGLKARNLIHARIE
ENIRAKICGLRAAGAGGGCKDALQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASA
ATSLITYLGLYPHVLQKVREELKSKGLLCKGNQDNKLDMEILEQLKYIGCVIKETLRLNP
PVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDAADIFTNKEEFNPDRFLLPHPEDAS
RFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWRLLNGPPTMKTSPTVYPVDDLPA
RFTRFQGEI*
CYP26A1 Canis familiaris (dog)
XM_844281.1
MGLSALLASALCTFVLPLLLFLAAIKLWDLYCVSSRDRSCALPL
PPGTMGFPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILL
GEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALQCYVPVIAEEV
GTCLQQWLSRGERGLLVYPQVKRLMFRISMRILLGCEPRLASGGDAEQQLVEAFEEMT
RNLFSLPIDVPFSGLYRGMKARNLIHARIEENIRAKICGLRTAQAGGGCKDALQLLIE
HSWERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKG
LLCKSNQDNKLDIEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELNGYQIPKGW
NVIYSICDTHDVADIFTNKDEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKI
LLKIFTVELARHCDWRLLNGPPTMKTSPTVYPVDDLPARFTHFQGEI
CYP26A1 Gallus gallus (chicken)
NM_001001129
MGFSALVASALCTFLLPLLLFLAAVRLWDLYCASGRDPSCPLPL
PPGTMGLPFFGETLQMVLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGAENVRHILL
GEHRLVSVQWPASVRTILGSGCLSNLHNGQHKHRKKVIMQAFSRDALQHYVPVIQEEV
SACLAQWLGAGPCLLVYPEVKRLMFRIAMRILLGFQPRQASPDGEQQLVEAFEEMIRN
LFSLPIDVPFSGLYRGLRARNIIHAKIEENIRAKMARKEPEGGYKDALQLLMEHTQGN
GEQLNMQELKESATELLFGGHETTASAATSLIAFLGLHHDVLQKVRKELQLKGLLSGP
NQEKQLNMEFLEQLKYTGCVIKETLRLSPPVPGGFRIALKTLELNGYQIPKGWNVIYS
ICDTHDVADLFTDKDEFNPDRFMSPSPEDSSRFSFIPFGGGLRSCVGKEFAKVLLKIF
TVELARSCDWQLLNGPPTMKTGPIVYPVDNLPAKFIGFSGQI
CYP26A1 Xenopus tropicalis (Western clawed frog)
NM_001016147.2 (seq gap) CX456558.2 CX423895.2 CX424757.1
69% to human CYP26A1
MDLYTLLTSALCTLALPVLLLLTAAKLWEVYCLSRKDASCRNPL
PPGTMGLPFFGETLQMVLQRRKFLQVKRRKYGRIYKTHLFGSPTVRVTGAENVRQILL
GEHKLVSVHWPASVRTILGAGCLSNLHDSEHKYTKKVIMQAFSREALANYVPLMEEEL
RRSVNLWLQSDSCVLVYPAIKRLMFRIAMRLLLGCDPQRLGREQEETLLEAFEEMTRN
LFSLPIDVPFSGLYRGLRARNIIHAQIEENIKEKLQREPDGQCRDALQLLIDHSRRTG
EPVNLQALKESATELLFGGHGTTASAATSLTTFLALHKDVLEK
VRKELESQGLLSNKPEEKKELSIEVLQQLKYTSCV
IKETLRLSPPVAGGFRVALKTFVLNGYQIPKGWNVIYSIADTHGEAELFPDKDE
FNPDRFLTPLPGDSSRFGFIPFGGGVRCCVGKEFAKILL
KVFIVELCRNCDWELLNGSPAMKTSPIICPVDNLPAKFKPFASSI
CYP26A1a Xenopus laevis (African clawed frog)
GenEMBL AF057566
Hollemann,T., Chen,Y., Grunz,H. and Pieler,T.
Regionalized metabolic activity establishes boundaries of retinoic
acid signalling.
EMBO J. 17, 7361-7372 (1998)
MDLYTLLTSALCTLALPLLLLLTAAKLWEVYCLRRKDAACANPL
PPGTMGLPFFGETLQMVLQRRRFLQVKRSQYGRIYKTHLFGSPTVRVTGAENVRQILL
GEHKLVSVHWPASVRTILGAGCLSNLHDNEHKYTKKVIAQAFSREALANYVPQMEEEV
RCSVNLWLQSGPCVLVYPAIKRMMFRIAMRLLLGCDPQRMDREQEETLLEAFEEMSRN
LFSLPIDVPFSGLYRGLRARNLIHAQIEENIKEKLQREPDEHCKDALQLLIDYSRRNG
EPINLQALKESATELLFGGHGTTASAATSLTSFLALHKDVLEKVRKELETQGLLSTKP
EEKKELSIEVLQQLKYTSCVIKETLRLSPPVAGGFRVALKTFVLNGYQIPKGWNVIYS
IADTHGEADLFPDTDKFNPDRFLTPLPRDSSRFGFIPFGGGVRCCIGKEFAKILLKVF
VVELCRNCDWELLNGSPAMTTSPIICPVDNLPAKFKPFSSSI
CYP26A1a Xenopus laevis (African clawed frog)
BG553607 df04c02.seq 15 BG555211 de99c02.x1 BG486543 dd01g02.x1
BE191823 db83b11.x1 AW198806 da06g04.x1 AW639706 bl86a09.w1 AW641576
cm08h09.w1 AW766054 da81f06.y1 BG161868 df69e06.x1 BE188917 db61c05.x1
AW460650 da29g11.x1 AW767659 da77a02.x1 AW640733 bl98d01.w1 AW199734
da06g04.y1 AW595907 da29g11.y2 AI031132 BE506442 db83b11.y1 BG038344
dg34a01.y1 BG486410 dc93f02.x1 AF057566 BG578446 de99c02.y1
SwissProt CP26A
MDLYTLLTSALCTLALPLLLLLTAAKLWEVYCLRRKDAACANPL
PPGTMGLPFFGETLQMVLQRRRFLQVKRSQYGRIYKTHLFGSPTVRVTGAENVRQILL
GEHKLVSVHWPASVRTILGAGCLSNLHDNEHKYTKKVIAQAFSREALANYVPQMEEEV
RCSVNLWLQSGPCVLVYPAIKRMMFRIAMRLLLGCDPQRMDREQEETLLEAFEEMSRN
LFSLPIDVPFSGLYRGLRARNLIHAQIEENIKEKLQREPDEHCKDALQLLIDYSRRNG
EPINLQALKESATELLFGGHGTTASAATSLTSFLALHKDVLEKVRKELETQGLLSTKP
EEKKELSIEVLQQLKYTSCVIKETLRLSPPVAGGFRVALKTFVLNGYQIPKGWNVIYS
IADTHGEADLFPDTDKFNPDRFLTPLPRDSSRFGFIPFGGGVRCCIGKEFAKILLKVF
VVELCRNCDWELLNGSPAMTTSPIICPVDNLPAKFKPFSSSI
CYP26A1b Xenopus laevis (African clawed frog)
AW765767 da77a02.y1 1-204 BE189825 88% 42-271
AW199734 da06g04.y1 BF047649 dc80h02.y1 BF426259 df69e06.y1
BG364937 dc93f02.y1 BG408452 dd01g02.y1
SwissProt Q5HZS9 100% to first 202 aa then diverges
Presumed ohnolog to CYP26A1a X. laevis
89% to CYP26A1a X. laevis
35 MDLYTLLTSALCTLALPVLLLLTAAKLWELYCLRRKDPTCANPLPPGTMGLPFFGETLQM 214
215 VLQRRKFLQMKRRKYGRIYKTHLFGSPTVRVTGAENVRQILLGEHKLVSVHWPASVRTIL 394
395 GAGCLSNLHDSEHKYTKKVIAQAFSRDALDNYVPQMEEEVRRSVNLWLQSGPCVLMYPAI 574
575 KRLMFRIAMRLLLGCDPQRMDSQ HEETLLEAFEEMTRNLFS 544
545 VPIDVPCSGLYRGLRARDLIHARIDENIEEKLLREPDDNCRDALQLLIDYSXRN
CYP26A1 zebrafish
GenEMBL U68234
White, J.A., Guo, Y.-D., Baetz, K., Beckett-Jones, B., Bonasoro, J.
Hsu, K.E., Dilworth, F.E., Jones, G. and Petkovich, M.
Identification of the retinoic acid-inducible all trans retinoic
acid 4-hydroxylase.
J. Biol. Chem. 271, 29922-29927 (1996)
Note: new family in vertebrates, homolog to human ESTs R51129 and
R21282
CYP26A1 Fugu rubripes (pufferfish)
ChrUn:295602053-295604410 (-) strand UCSC browser
Scaffold_12575 (old)
66% to 26A1 human
revised 5/20/2010
MAVSALLATFLCTIVLPLLLFLVTVKLWEVY VIRERDSACP SPLPPG
TMGLPFIGETLQLILQ (0)
RRKFLRMKRQKYGYIYRTHLFGNPTVRVTGANNVRHILLGEHRLVAV
QWPASVRTILGSDTLSNVHGAQHKTKKK (0)
AIMQAFSREALEFYIPAMQHEVQAAVQEWLAKDSCVLVYPEMKRLMFRIAMQILLGFQLE
QIKTDEQKLVEAFEEMIKNLFSLPIDMPFSGLYR (0)
GLKARNFIHAKIEENIKRKLRESNSDSKCRDALQQLIDSSKKSGQVLSMQ (0)
VLKESATELLFGGHETTASTATSLIMFLGLNPEVLDKLRHELSDKVMHKGF (1)
LDLRSLNLETLEQLKYTSCVIKETLRMNPPVPGGFRVALKTFELG (0)
GYQIPKGWNVIYSICDTHDVAEIFP
NKEDFQPE
RFMMKNCGDSSRFQYIPFGGGSRMCVGKE &
VCQSSSEDLSGRSGYKVPLESFEWTTHNENRTYSLSCGQSTNQI*
CYP26A1 Tetraodon nigroviridis (Green puffer)
89% to fugu CYP26A1
MALSALLATFLCTIVLPFLLFLVTVKLWEVYMIRGKDAACPSPLPPGSMGLPFIGETLQLILQ (0)
RRKFLRMKRQKYGYIYRTHLFGNPTVRVTGAANVRHILLGEHRLVAVQWPASVRTILGPDTLSNVHGAQHKTKKK (0)
AIMQAFSREALELYIPAMQEEVQAVVQEWLAKDSCVLVYPEIKRLMF
RIAMRLLLGFELEQIKTDEQQLVEAFEEMIKNLFSLPIDVPFSGLYR (0)
GLKARNFIHAKIEENIKRKLQESNSESRDALQQLIDSSKKSGHMLSMQ (0)
ALKESATELLFGGHETTASTATSLIMFLGLNPDVLDKLRQELIDKVSKSF (0)
GLDLRSLSVEALEQLKYTSCVIKETLRMNPPVPGGFRVALKTFKLG (0)
GYQIPKGWNVVYSICDTHDVAEIFSNKGDFQPERFMASHHGDASKFQYI
PFGGGSRMCVGKELCQSPAKDLSGRSGQNVSLEPSERATHHENGTDGLSCGQSAYKI*
CYP26B1 human
GenEMBL AC007002
Nelson, D.R. A second CYP26 P450 in humans and zebrafish: CYP26B1
Archives of Biochemistry and Biophysics 371, 345-347 (1999)
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQ
GSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVSNS
IGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSHPEAINVYQEAQ
KLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFVDNVFSLPVDLPFSGYRR
GIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGKEMTMQELKDGTLELIF
AAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLRLDTLSGLRYLD
CVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDP
DRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRI
TLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
CYP26B1 Pan troglodytes (chimpanzee)
XM_001149367.2
99% (2 aa diffs) to human
MLFEGLDLVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKS CKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENV RKILMGEHHLVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPK IQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFV DNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDLLIESSKE HGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHS GGCPCEGTLRLDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSV MYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLF LKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPETEAML
SATV
CYP26B1 Bos taurus (cow)
See cattle page for details
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQ
GSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRML
LGPNTVSNSIGDIHRNKR
VFSKIFSHEALESYMPKIQLVIQDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLG
FSLPVDLPFSGYRRGIQARQTLQKG
77 LEKAIREKLQCTQGKDYSDALDIFIESSKEHGKEMTMQELKDGTLELIFAAYAT 238
239 TASASTSLIMQLLKHPAVLEKLREELRAKGLLHSGGCPCEGTLRLDTLSGLHYLDCVIKE 418
419 VMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFG 592
593 QARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVL 700
AVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPETEAMLSATV*
CYP26B1 pig
AK238570.1, CJ034657.1
aa 88-142
LLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNTVANSIGDIHRNKR
CYP26B1 Canis familiaris (dog)
XM_540236.2
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKS
CKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENV
RKILMGEHHLVSTEWPRSTRMLLGPNTVANSIGDIHRNKRKVFSKIFSHEALQSYLPK
IRLVIQDTLRAWSSHPEAINVYQETQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQQFV
ENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKE
HGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGILHS
GGCPCEGTLRLDTLSRLHYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSV
MYSIRDTHDTAPVFKDVNVFDPDRFGQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLF
LKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNKILPETEAML
SATV
Cyp26b1 mouse
GenEMBL AC022779.3 AW047279 GSS AZ741670, AZ369731, BM936625.1
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQ (0)
GSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRK (0)
VFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSI
PEEDLGHLFEVYQQFVENVFSLPVDLPFSGYRR (?)
GIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELK
DGTLELIFAAYATTASASTSLIMQLLK
HPAVLEKLREELRAQGLLHGGGCPCEGTLRLDTLSSLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELD (?)
GFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLP
FGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
Cyp26b1 rat
CYP26B1 chicken
XM_426366
missing N-term, 86% to CYP26B1 human
EVFSKI
FSHEALESYLPKIQLVIKDTLRAWSSNPDPINVYHEAQKLTFRMAIRVLLGFHIPDEE
LSRLFEVYQQFVENVFSLPVDLPFSGYRRGIRARETLQRGLEKAIQEKLQNTQGKDYA
DALDILIESGKEHGKELTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPRVLEKL
REELRSKGILHNGCICEGSLRLDNISGLHYLDCVIKEVLRLFTPISGGYRTVLQTFEL
DGFQIPKGWSVMYSIRDTHDTAPVFKDVDVFDPDRFGQGRSEDKEGRFHYLPFGGGVR
TCLGKHLAKLFLKALAIELASSSRFELATRTFPKITLVPVVHPVDGLKVKFFGLDSNQ
NEILTGTDVMLGATV
CYP26B1 Taeniopygia guttata (zebrafinch)
chr4_random:4476367-4492499 UCSC browser
MLFASFDLVSALATLAACLVSLTLLLAVSQQLWQLRWAATRDKTCKLPIPKGSMGFPLIG
ETFHWLLQ
aa 67-143 missing in a seq gap
VFSKIFSHEALESYLPKIQLVIKDTLRAWSSNAEPINVYHEAQKLTFRMAIRVLLGFRIP
DEELGRLFEVYQQFVENVFSLPVDLPFSGYRR ()
GIRARETLQKGLEKAIQEKLQNTQGKDYADALDILIESGKEHGKELTMQELK
DGTLELIFAAYATTASASTSLIMQLLKHPRVLEKLREELRSKGILHNGCICEGSLRLD 3348
NINGLQYLVCVINEVLRLFTPISGGYRTVLQTFELD
GFQIPKGWSVMYSIRDTHDTAPVFKDVDVFDPDRFGQGRSEDKDGRFHYLPFGGGVRTCL
GKHLAKLFLKALAIELASTSRFELATRTFPKITLVPVVHPVDGLKVKFFGLDSNQNEILT
GTDAMLGATV
CYP26B1 Xenopus tropicalis (Western clawed frog)
CX905408.1 CX388776.2 CX940676.2
82% to human 26B1
MIFQSFDLVSALATLAACLVSVALLLAVSQQLWQ
LRWAATRDKSCKLPIPKGSMGFPLVGETFHWILQGSDFQSSRREKYGNVFKTHLLGRPLI
RVTGAENVRKILMGEHHLVSTEWPRSTRMLLGPNSLANSIGDIHRHKRKVFSKIFSHEAL
ESYLPKIQLVIQDTLRVWSSNPESINVYCEAQKLTFRMAIRVLLGFR
LSDEELSQLFQVFQQFVENVFSLPVDVPFSGYRRGIRAREMLLKSLEKAIQEKLQNTQGK
DYADALDILIESGKEHGKELTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPSVLEK
LREELRGNSILHNGCVCEGALRVETISSLHYLDCVIKEILRLFSPVSGGYRTVLQTFELD
GFQIPKGWSVLYSIRDTHDTAPVFKDVDVFDPDRFGQDRTEDKDGRFHYLPFGGGVRNCL
GKHLAKLFLKVLAIELASMSRFEL
ATRTFPKIMPVPVVHPADELKVRFFGLDSNQNEIMTETEAMLGATV*
CYP26B1 Xenopus laevis (African clawed frog)
SwissProt B5A5V8
97% to X. tropicalis
missing some N-term and some C-term
QLRWAATRDKSCKLPIPKGSMGFPLVGETFHWILQGSGFQSSRREKYGNVFKTHLLGRP
LIRVTGAENVRKILMGEHHLVSTEWPRSTRTLLGPNSLANSIGDIHRHKRKVFSKIFSH
EALESYLPKIQLVIQDTLRVWSSNQESINVYCEAQKLTFRMAIRVLLGFRLSDEELSQL
FQVFQKFVENVFSLPVDVPFSGYRRGIRARETLLKSLEKAIQEKLENTQGKDYADALDI
LIESGKEHGKELTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPSVLEKLREELRG
NGILHNGCVCEGALRVETISSLHYLDCVIKELLRLFSPVSGGYRTVLQTFELDGCQIPK
GWSVLYSIRDTHDTAPVFKDVDVFDPDRFGQDRTEDKDGRFHYLPFGGGVRNCLGKHLA
KLFLKTLAIELASMSRFELA
CYP26B1 Danio rerio (zebrafish)
See zebrafish pages for seq
CYP26B1 Fugu rubripes (pufferfish)
No accession number
Scaffold_4267
74% to 26B1 human
8448 MLFDSFDLVSALATLAACLVSMALLLAVSQQLWQLRWTATRDRNCKLPMPKGSMGFPFIGETCHWLLQ 8651
17930 GSGFHASRRQKYGNVFKTHLLGRPLIRVTGAENIRKVLMGEHTLVTVDWPQSTSTLLGPNSLA 18118
18119 NSIGDIHRKKRK 18154
1487 VFAKVFSHEALESYLPKIQQVIQESLRVWSSNPEPINVYR 1606 (2)
1689 ESQRLSFTMAVRVLLGFRVSEEEMKHLFSTFQDFVDNLFSLPIDLPFSGYRK 1844 (0)
1921 GIRARDTLQKSIEKAIREKPLCSQGKDYSDALDVLMESAKENGSELTMQELK 2076 (0) exon 4
2851 ESTIELIFAAFATTASASTSLIMQLLRHPPVLERLREELRARGL exon 5,6 fused
LHNGCLCPEGELRLDTIVSLKYLDCVIKEVLRLFTPVSGAYRTAMQTFELD 3135 (0) exon 5,6 fused
3271 GVQIPKGWSVMYSIRDTHDTSTVFKDVDVFDPDRFSQERGEDKEGRFHYLPFGGGVRSCLGKQLA exon 7
TLFLRILAIELASTSRFELATRQFPRVITVPVVHPVDGLKVKFYGLDSNQNEIMAKSEELLGAAV* 3663 exon 7
CYP26B1 Tetraodon nigroviridis (Green puffer)
99% to CYP26B1 fugu
MLFDSFDLVSALATLAACLVSMALLLAVSQQLWQLRWTATRDRNCKLPMPKGSMGFPFIGETCHWLLQ (0)
GSSFHASRRQKYGNVFKTHLLGRPLIRVTGAENIRKVLMGEHTLVTVDWPQSTSTLLGPNSLANSIGDIHRKRRK (0)
VFAKVFSHEALESYLPKIQQVIQESLRVWSSNPEPINVYR (2)
ESQRLSFTMAVRVLLGFRVSEEEMKHLFSTFQDFVDNLFSLPIDLPFSGYRK(0)
GIRARDTLQKSIEKAIREKPLCSQGKDYSDALDVLMESAKENGSELTMQELK (0)
ESTIELIFAAFATTASASTSLIMQLLRHPPVLERLREELRARGLLHNGCL CPEGELRLDTIVSLKYLDCVIKEVLRLFTPVSGAYRTAMQTFELD (0)
GVQIPKGWSVMYSIRDTHDTSTVFKDVDVFDPDRFSQERGEDKEGRFHYLPFGGGVRSCLGKQLANL
FLRLLAIELASTSRFELATRQFPRVITVPVVHPVDGLKVMFYGLDSNQNEIMAKSEELLGAAV*
CYP26C1 human
GenEMBL AL358613.11 May 2, 2001
522 amino acids, 6 exons, (0) = phase 0 intron
52% to 26B1 human, also 15 amino acid insertion in exon 5 vs. 26B1
MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRASTLPLPKGSMGWPFFGETLHWLVQ (0)
GSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRK (0)
VLARVFSRAALERYVPRLQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGLRL
DEAQCATLARTFEQLVENLFSLPLDVPFSGLRK (0)
GIRARDQLHRHLEGAISEKLHEDKAAEPGDALDLIIHSARELGHEPSMQELK (0)
ESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRACGCAPGAAGGSEGPPPD
CGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELD (0)
GYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSRLHYIPFGGGARSCLG
QELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGLRLFFHPLTPSVAGNGLCL*
CYP26C1 Pan troglodytes (chimpanzee)
XM_003312686 revised
99% (2 aa diffs) to human
MFPWGLSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWMLSRDRA STLPLPKGSMGWPFFGETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENV RTILLGEHRLVRSQWPQSAHILLGSHTLLGAVGEPHRRRRKVLARVFSRAALERYVPR LQGALRHEVRSWCAAGGPVSVYDASKALTFRMAARILLGLRLDEAQCATLARTFEQLV ENLFSLPLDVPFSGLRKGIRARDQLHQHLEGAISEKLHEDKAAEPGDALDLIIHSARE LGHEPSMQELKESAVELLFAAFFTTASASTSLVLLLLQHPAAIAKIREELVAQGLGRA CGCAPGAAGGSEGPPPDCGCEPDLSLAALGRLRYVDCVVKEVLRLLPPVSGGYRTALR TFELDGYQIPKGWSVMYSIRDTHETAAVYRSPPEGFDPERFGAAREDSRGASSR FHYIPFGGGARSCLGQELAQAVLQLLAVELVRTARWELATPAFPAMQTVPIVHPVDGL
RLFFHPLTPSVAGNGLCL
CYP26C1 Bos taurus (cow)
See cattle page for details
67 MLPWGLSCLSALGAVGTALLGAGLLLSLAQHLWTLRWTLSRDRASALPLPKGSMGWPFFGETLHWLVQ (0)
GSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTVLLGEHRLVRSQWPQSAHILLGSHTLLGAVGESHRQRRK (0)
5955 ILARAFSRAALECYVPRLQRALRREVRSWCAARGPVAVYEAAKALTFRMAARILLGLR 6134
6135 LDEAQCSELARTFEQFVENLFSLPLDVPFSGLRK (0) 6251
GIRARDQLHRHLEEAIAQKLLEDKTAVEPGDALDGIIHSTRELGHELSVQELK (0)
46 ESAVELLFAAFSTTASASTSLVLLLLQHPAAIAKIQQELAAQGLGRACGCAPAASGGG 225
226 AGPPPDCGCEPDLSLAALGHLRYVGCVVKEVLRLLPPVSGGYRTALRTFELD (0) 381
GYQIPKGWNVMYSIRDTHETAAVYRSPPEGF
DPERFGTAGDDALGAAGRFHYIPFGGGARSCLGQELAQTVLQLLAVELVRTARWELATPA 2322
2321 FPAMQTVPIVHPVDGLRLFFHPLASPAAQDGQRS*
CYP26C1 Canis familiaris (dog)
XM_845174.1 partial, end in a seq gap,
91% to human
MFPWGPSCLSVLGAAGTALLCAGLLLSLAQHLWTLRWTLSRDRASALPLPKGSMGWPFFGETLHWL
VQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRLVRSQWPQSAHILLG
SHTLLGAVGEPHRRRRKVLARVFSRAALQRLVPRLQGALRREVRSWCAARRPVAVYQAAK
ALTFRMAARILLGLRLDEVQCAELARTFEQFVENLFSLPLDVPFSGLRK
GIRARDQ
LHRYLEEAIAEKLHEDKVAEPGDALDMIIHSTRELGHELSVQELK
ETAGELLFAAFLTTASASTSLV
CYP26C1 mouse
GenEMBL AC110212.1
84% to 26C1 human exon 5
ELAVELLFAAFFTTASASTSLILLLLQHPAAITKIQQELSAQGLGRACTCTPRASGSPPDCGCEPDLSLAMLGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELD
Cyp26c1 mouse
GenEMBL XM_140712.1 May 17, 2002 also AC110212.4
1 MISWGLSCLSVLGAAGTTLLCAGLLLGLAQQLWTLRWTLSRDWASTLPLPKGSMGWPFFG 180
181 ETLHWLVQGSRFHSSRRERYGTVFKTHLLGRPVIRVSGAENVRTILLGEHRL 338
339 VLARVFSRSSLEQFVPRLQGALRREVRSWCAAQRPVA 447
448 VYQAAKALTFRMAARILLGLQLDEARCTELAHTFEQLVENLFSLPLDVPFSGLRKGIRAR 627
628 DQLYEHLDEAVAEKLQEKQTAEPGDALLLIINSARELGHEPSVQELK
ELAVELL 987
988 FAAFFTTASASTSLILLLLQHPAAITKIQQELSAQGLGRACTCTPRASGSPPDCGC 1155
1156 EPDLSLAMLGRLRYVDCVVKEVLRLLPPVSGGYRTALRTFELDGYQIPKGWSVMYSIRDT 1335
1336 HETAAVYRSPPEGFDPERFGVESGDARGSGGRFHYIPFGGGARSCLGQELAQAVLQLLAV 1515
1516 ELVRTARWELATPAFPVMQTVPIVHPVDGLLLFFHPLPTSGAGDGLPF*
Cyp26c1 rat
CYP26C1 chicken
XP_421678, XM_421678.2
70% to CYP26C1
1 MRSGRDAVRR RGAAGSRLGS GWVGPGWAVG GEPRGASPQG AVAATPVRPA PLPSIPALRL
61 QSPHLAALLK YAGETSSAKV DRALSGQYLY KCGRGEKREQ EPCGGISHWL LQGSRFHSSR
121 RERYGNVFKT HLLGRPVVRV TGAENVRKIL LGEHTLVSAQ WPQSTQILLG SHTLLGSTGD
181 LHRQRRKILA RVFCRAALES YLPRIQKVVS WELRGWCMQP GSIAVYSSAK TLTFRIAARI
241 LLGLRLEEKQ FKDLAKTFEQ LVENLFSLPL NVPFSGLRKG IKARDMLHEF MERAIQEKLQ
301 RAISEEHSDA LDFIINSAKE HGKEFTMQEL KESAIELIFA AFFTTASAST SLILLLLKHP
361 SAIEKIRQEL VSHELPQPRG CRCPLDISLE QLSRLRYLDC VVKEVLRVLP PVSGGYRTAL
421 QTFELDGYQI PKGWSVMYSI RDTHETAAIY QSPPGGFDPD RFNVTHLEAA GRFHYIPFGG
481 GARSCIGKEL AQAILKLLAI ELVTTARWEL ATPTFPAMQT VPIVHPVDGL QLYFHPLRPS
541 HGGEA
CYP26C1 Xenopus tropicalis (Western clawed frog)
CX830022.1 CN120927.1 CR567555.1 CX376643.2 CR567556.1
65% to human 26C1
note this seq has in insertion compared to human, but
the insertion is supported by several ESTs and is real
also seen in X. laevis (see below)
MFLLEISYTSFFEAALTSALSLVLLLAASHQLWS
LRWHSTRDRGSSLPLPKGSMGWPFFGETLHWLVQGSSFHSSRREKYGNIFKTHLLGKPVI
RVTGAENIRKILLGEHHLVSTQWPQSTQIILGSNTLSNSIGELHRQKRKMMSKVLSSAAL
ESYLPRIHEAVRWEVRSWCRGVGPVSMLSCAKALTFRIAARILLGLSLTDTQFQELTRTF
EQLVENLFCLPLDIPFSGLRKGMKARDTLHQYMEEAIKEKLSKRDPDACEDALDYLINSA
KEGGKEINMQELKESAIELIFAAFLTTASASTSLVLLLLKHPSAIHKIRQELASHGL
SEHCEQCLPATENPNNNILQDNGHQCLTAGCQLPLVMGTEGQVKTLWEQTKQLLTDRTDK
DPQNSLSSKNLVNGENRIQEAPCSHDKSNCSPVPGKLQNSVFEGT
CQQNISLEKLKSLHYLDC
VVKEVLRLLPPVSGGYRTALQTFELDGYQIPKGWSVMYSIRDTHETAAVYQNAEMFDPER
FSTERDEGKLGRFNYIPFGGGARSCIGKELAQIILKILAMELVTTAKWELATPSFPKM
QTVPVVHPVDGLQLSFSFLGSNDSDKAARNRSLANP*
CYP26C1 Xenopus laevis (African clawed frog)
BG264135 de80c01.y1 BG439345 de80c01.x1
67% to 26C1 human, 57% to 26B1 human, 45% to 26A1 human
108 NLEKLKSLHYLECVVKEVLRLLPPVSGGYRTALQTFELDGYQIPKGWSVMYSIRDTHETA 287
288 AVYQNAEMFDPERFSTERDEGKLGKFNYIPFXGGVRSCIGKELAKVILKILAMEL 452
VTTAKWELATPSFPKMQTVPVVHPVDGLQLSFSFLSDSDTEAKNGSRANP*
CYP26C1 Xenopus laevis (African clawed frog)
SwissProt Q2T9K4, GenEMBL BC111476
Deleted some poor sequence at the C-term (see above)
MFLLEISYTSFFEATLTSVLSLVLLLAASHQLWSLRWHSTRDRGSTLPLPKGSMGWPFF
GETLHWLVQGSSFHSSRREKYGNVFKTHLLGKPVIRVTGAENIRKILLGEHSLVSTQWP
QSTQMILGSNTLSNSIGELHRQKRKVMSKVLSSAALECYFPRIQEAVRWEVRGWCRGVG
PVSMFACAKALTFRIASRILLGLSLTDSQFHELARTFEQLVENLFSLPLDIPFSGLRKG
IKARDTLHQYMEEAIKEKLTRRDPDACEDALDYLINSAKEGGKEINMQELKESAIELLF
AAFLTTASASTSLVLLLLKHPSAILKMRQELASHGFSKQCQCLPDMENPNNNILQDNGH
RCLTAGCQLPLLMGTEGHLKTQGEQTEQLLTDKTDPQNSLSSKNPLKGKNRIQEAPCSH
DKSTCTPVPGKLQSPVSEGTSQQNSNLEKIKSLHYLECVVKEVLRLLPPVSGGYRTALQ
TFELDGYQIPKGWSVMYSIRDTHETAAVYQNAEMFDPERFSSERDEGKLGKFNYIPFGG
GVRSCIGKELAKVILKILAMELVTTAKWELATPSFPKMQTVPVVHPVDGLQLSFSFLS
CYP26C1 Danio rerio (zebrafish)
BC129131.1, NM_001029951.2
Zv8 Chr 17 17124710-17134145 (+) strand 100%
Note: this is revised from an earlier version
MFGHDFCLVSALLSVADAVLPTVLLLAVSRLLWEFRWSITRDRTCKLPLPQGSMGWPLV
GETFHWLFQGSSFHISRREKHGKVFKTHLLGKPLIRVTGAENIRKILLGEHTVVCTQWP
QSTRIILGPNTLVNSVGDLHKRKRKVLAKVFSRGALEAYLTRLQDVVKSEIAKWCTETG
SVEVYTAAKSLTFRIAVRVLLGLHLEEQQITYLSKTFEQLMNNLFSLPIDTPVSGLRKG
IRAREILHSAMEKIIEEKLKKQQASDYCDAFDYMLSSARENDYELTMQELKETAVELIF
AAHSTTASASTSLIMQLLRHPDVSERARAELESEGLITDGHGHCRSRCNGNAISEEGEA
AEKSTSDRRSAINKATYFEAGDKEEGRRSRTHVPYLSLEKLSQLSYLDCVVKEVLRFLP
PVSGGYRTVLQTFELNGYQIPKGWSVMYSIRDTHETAEAYQNPELFDPDRFCVGREESK
SERFSYVPFGGGVRRCIGRELALIVLKTLAVELLATADCTLATQTYPRMQTVPIVHPVN
GLHVFFNYRTQGIERNRRESTHI
CYP26C1P Fugu rubripes (pufferfish)
No accession number
Scaffold_11741
Equally similar to 26B1 and 26C1 human
But C-terminal is 68% to 26C1 while 58% to 26B1
Lower case region very poor match may not be correct
exon structure here.
Danio has cDNA for CYP26C1. It is 21 amino acids longer
Than pufferfish genomic DNA can code for.
Therefore, Pufferfish have either shortened CYP26C1 or they
are now pseudogenes
6362 MLGLVSALATALTTLLLLLLLLALTRQLWSFRWSLTRDRRCELPLPKGSMGWPLVGETFQWLFQ 6171 (0)
5571 GSNFHISRRKRHGNVFKTHLLGKPLVRVTGAENIRKILLGEHSLVCTQWPQSTRIILGPN 5392
5391 ALVNSIGELHKRKRK 5347 (0)
4963 ILAKVFSRKALESYLPRLQEVIKCEIAKWCAEPGSVDVYAATRSLTFRIAIGVLLGLHL 4781
4780 EEERIDYLAQIFGQLMSNLFSLPIDAPFSGLRK (0)
3972 GIKARKILHANMEKIIEKKMERQQEEEEYRDAFDYMLSTSKEQGQQISIQELK 3814 (0)
3581 ETAVELIFAAHSTTASAATSLVLQLLHHPEVVERVRVELEAQKLcynslnlpsqa 3417 (1?)
3377 ctfpqsqchasnLSLDKLNQLHYIDCVIKEVLRFLPPVSGGYRTALQTFELD 3222 (0)
2770 GYQIPKGWTVMYSIRDTHETAEIFQNPELFDPDRFVTAQVESRSSRFSYVPFGGGVR 2600
2599 SCVGKELAQIILKTLTIELIRTCKWTLATEKFPKMQTVPIVHPVNGLHVNFMYKNLHEIDH* 2414
CYP26C1P Tetraodon nigroviridis (Green puffer)
missing some seq in the middle and frameshited
~81% to fugu CYP26C1
Danio has cDNA for CYP26C1. It is 21 amino acids longer
Than pufferfish genomic DNA can code for.
Therefore, Pufferfish have either shortened CYP26C1 or they
are now pseudogenes
MLGLLSALATALTSLLSLLALLALTRQLWSLRWSLTRDRRCELPLPEGSMGWPLVGETFQWL (2)
FQGSNFHISRRKRHGNVFKTHLLGKPLIRVTGAENIRKVLMGEHTLVCTQWPQSTR IILGPNTLVNSSGELHKRRRKVAGRT (1)
SKVFSRRALESYLPRLQHLIRSEIAKWCAEPAA VDVYSATRSLTFRIAIGVLLGLRLDEERIIYLAQVFEQLMSNLFSLPVDIPLSGLHK (0)
GIKAREILHANMEKIIQEKLEQQNQEEHQDAFDYMLSTAKEQGQQISIQELK (0)
ETAVELIFAAHSTTASAATSLVLQLLLHPEVVERVRLELEGHNL (0?)
srvvcplSWSRVPDVSLEQLNQLSYLDQVIRE &
LLRLLPPVSGGYRTALQTFELD (0)
GYQIPKGWSVMYSIRDTX &
ETAEIFQNPELFDPDRFDQDQLESRSSRFSYVPFGGGVRSCVGKELAQIILKTLSIELIG
TCTWTLATENFPRMQTVPVVHPVNGLHVNFMYDN*
27A Subfamily
CYP27A1 human
Swiss Q02318 (531 amino acids)
Cali J.J., Russell D.W.
Characterization of the human sterol-27-hydroxylase: A mitochondrial
P450
that catalyzes multiple oxidation reactions in bile acid
biosynthesis.
J. Biol. Chem. 266, 7774-7778 (1991)
CYP27A1 human
GenEMBL X59812 (2107bp)
Guo,Y., Strugnell,S., Back,D.W. and Jones,G.
Transfected human liver cytochrome P-450 hydroxylates vitamin D
analogs at different side-chain positions
Proc. Natl. Acad. Sci. U.S.A. 90, 8668-8672 (1993)
CYP27A1 human
NM_000784
MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAP
GAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGP
QMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQA
LNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAIC
YILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWN
AIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLM
AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKE
TLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL
RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGEL
KSVARIVLVPNKKVGLQFLQRQC
CYP27A1 Pan troglodytes (chimpanzee)
XM_001159436.2
99% (3 aa diffs) to human
MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALPSDKATGAP GAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGP QMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHDLTYGPFTTEGHHWYQLRQA LNQRLLKPAEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAIC YILFEKRIGCLQRYIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWN AIFSFGKKLIDEKLKDMEAQLQAAGPDGIQVSGYLHFLLASGQLSPREAMGSLPELLM AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHMPLLKAVLKE TLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTAFSEPESFQPHRWL KNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGEL
KSVARIVLVPNKKVGLQFLQRQC
CYP27A1 Macaca fasicularis (cynomolgus monkey)
DQ074803
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP27A1_18D1
100% to AB125162, 97% to human
MAALGCARLRWVLRGAGRGLCPHGARAKATIPTALPSDKATEAP
GAGPGIRRRQRSLKEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGP
QMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDLHDLTYGPFTTEGHHWYQLRQA
LNQRLLKPAEAALYTDAFNEVIDDFMIRLDQLRAESASGNQVSDTAQLFYYFALEAIC
YILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLPKWTRPVLPFWKRYLDGWN
AIFSFGKKLIDEKLEDMEAQLQAEGPDGVQVSGYLHFLLASGQLSPREAMGSLPELLM
AGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPAGQVPQHKDFAHLPLLKAVLKE
TLRLYPVVPTNSRIIEKEIEVDGFLFPKNTQFVFCHYVVSRDPTTFSEPESFQPHRWL
RNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGEL
KSVARIVLVPNKKVGLQFLQRQC
CYP27A1 Macaca fasicularis (cynomolgus monkey)
GenEMBL AB125162
Kusuda,J., Osada,N., Tanuma,R., Hirata,M., Sugano,S. and
Hashimoto,K.
Isolation and characterization of cDNA for macaque neurological
disease genes
Unpublished, partial seq
CYP27A1 Papio hamadryas (hamadryas baboon)
AF062488
SCREGHHWYQLRQALNQRLLKPAEAALYTDAFNEVIDDFMIRLD
QLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMF
QNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAEGPDGVQ
VSGYLHFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPE
CYP27A1 Bos taurus (cow)
See cattle page for details
MNRMGALGSARLRWALLGRRAALPGLGSFGARAKAAIPSALPAAQAAEAPGTGPGDRRLRSLD
ELSGPGQLRLLFQLLVQGYVLHLHQLQVLNKAKYGPIWINRVGPQMHVHLASAPLLEQVM
RQEGKYPVRDDMKLWKEHRDQQGLSYGPFTTMGEQWYRLRQTLNQRMLKPAEAALYTDAL
NEVINDFMDQLKQLRAESASGDHVPDIAHQFYFFALEAISYILFEKRIGCLERSIPKDTE
TFVRSVGLMFHNSLFVTFLPTWTRPLLPFWKRYLDGWNTIFSFGKKLIDQKLEEIEAQLK
TENPEKTQISGYLHFLLTSG
QLSPREAEGSLPELLLAGVDTTSNTLTWALYHLSKNPEIQAALHKEVVGVVPAGQVPQHK 961
DLARMPLLKAVLKETLRLYPVVPVNSRVVVDKEIEVGGFLFPKNTQFVLCHYVISRDPDI 1141
YPEPDSFQPQRWLRKNQPDALKTQHPFGSVPFGYGVRACLGRRIAELEMQLLLTRLIQHYE 1324
VVLAPETGEVTSVARIVLVPNKKVGLRFLQRQS*
CYP27A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
3 amino acid differences to complete seq AK232936.1
Ortholog of human CYP27A1
CYP27A1 pig
AK232936.1
MAALGCARLRWALLGTRVPFPVIGSQGARAKAAIPTALPAAQTAEAPGTGPGDRRLRTLKELSGPGRLRLLFQLLAQGYVLHLHQLQVLNKAKYGPMWINYIGPQIHVNVASAPLLEQVMRQEGKYPVRNDMDLWKEHRDLQGLTYGPFTTEGESWYRLRQALNQRMLKPADAALYTNALNEVVDDFMVRLNQLRAESTLGDHVPDIAHQFYFFALEAICYILFEKHIGCLERSIPQDTKAFVRSVGFMFQNSLYATFLPKWTRPLLPYWRRYLDGWNTIFSFGKKLIDQKLEEIEAQLQAGGPEEPRISGYLHLLLTSGQLSPREAEGSLPELLMAGVDTTSNTLTWALYHLSKNPEIQAALHEEVVGMVPAGRVPQYKDLAHMPLLKAVLKETLRLYPVVPVNSRVTDKEIEVGGFLFPKNTQFVLCHYVVSRDPSIFPEPDRFSPKRWLRKNQTDALKGQHPFGSVPFGYGVRGCLGRRIAELEMQLLLTRLIQQYEVTLAPETGEVQSVARIVLVPNKKVGLRFLQRQG
CYP27A1 Canis familiaris (dog)
XM_848001.1
MGRSLPVSLLGARGAPAGLCPRGARAKAAIPAAVPATAETPGNG
PGARRLRTLEELPGPGQLRFLFQLLGQGYVLQLHKLQVLNKAKYGPMWVTHAGPQTHV
NLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQQGLAYGPFTTEGHHWYQLRHALNQR
MLKPSEAALYTDALNEVVDDFMAHLSQLLAESPSGNQVSDMAHQFYYFALEAICYILF
EKRIGCLERPIPQDTVAFVRSVGLMFQNSVYVTFLPKWTRPLLPFWKRYLDGWNTIFS
FGKKLIDQKLKEIETQLQTKGPDEVEISGYLHFLLTRGQLSTREAMGSLPELLLAGVD
TTSNTMTWALYHLSKNPEIQAALHKEVVGVVPPGQVPQQKDFAHMPLLKAVLKETLRL
YPVVPINSRVITEKEIEVNGFLFPKNTQFVFCHYVVSRDPDIFPEPESFQPYRWLRKS
QLAAPGVHHAFGSVPFGYGVRACLGRRIAELEMQLLLSRLIQQYQVVLAPETGEVKSL
ARIVLVPNKKVSLHFQPRQC
CYP27A1 rat
GenEMBL M73231 (2300bp)
Shayiq,R.M. and Avadhani,N.G.
Sequence complementarity between the 5'-terminal regions of mRNAs
for
rat mitochondrial cytochrome P-450c27/25 and a growth hormone-
inducible
serine protease inhibitor: a possible gene overlap.
J. Biol. Chem. 267, 2421-2428 (1992)
CYP27A1 rat
GenEMBL U17363, U17369 to U17376 genomic sequence
Mullick, J., Addya,S., Sucharov,C. and Avadhani,N.G.
Localization of a transcription promoter within the second exon of
the cytochrome P-450c27/25 gene for the expression of the major
species of two-kilobase mRNA.
Biochemistry 34, 13729-13742 (1995)
Cyp27a1 mouse
GenEMBL 8 ESTs follow AI286988 AK004977.1 Mm.26793
MAAWSRTRLRWTLLDPRVVGRGLCPQGARAKATIPAALQAQESTEGPGTGQDRPRLRSP
AELPGTGTLQFLFQLFLQGYVLHLPDLQVLNKTKYGPMWTTSFGTYTNVNLASAPLLEQV
MRQEGKYPIRDHMDQWKDHRDHKGLTYGIFIAQGEQWYHLRQALKQRLLKPDEAALYTDA
LNEVISDFITRLDQVRAESESGDQVPDMAHLLYHLALEAITYILFEKRIGCLKPSIPEDT
AAFIRSVAIMFQNSVYITFLPKWTRPLLPFWKRYLNGWDNIFSFGKKLID EKVQELKAQL
QETGPDGVRVSGYLHFLLTNELLSTQETIGTFPELLLAGVDT TSNTLTWALYHLSKSPEI
QEALHKEVTGVVPFGKVPQHKDFAHMPLLKAVIKETLRLYPVVPTNSRIITEKETEINGF
LFPKNTQFVLCHYVVSRDPSVFPEPNSFQPHRWLRKKEADNPGILHPFGSVPFGYGVRSC
LGRRIAELEMQLMLSRLVQKYEIALAPGMGEVKTVSRIVLVPSKKVRLHFLQRQ
CYP27A1 Mesocricetus auratus (hamster)
ACQ99543
1 RLRWALLGTR VVGRGLCPQG ARTKAAIPAA LRADENVEGP RGGQDQRRLR SLEDLPGPGQ
61 LRFLSQLFLQ GYLLRLHELQ ALNKVKYGPM WTTPFGTQAH VNLASASLLE QVMRQEGKYP
121 IRDHMEQWKD HRDHTGLTYG IFLTQGHQWY QLRQALNKRL LKPAEAALYT NAFNEVIDDF
181 ITRLSQVQAE SASGDQVPDM AHLLYHFALE AICYVLFEKR VGCLEPSIPE DTATFIRSVG
241 LMFQNSLYVT FLPKWTRPLL PYWKRYLNGW DNIFSFGKKL IDQKVKEVEA QLQAAGPDGV
301 QISGYLHFLL TNELLSPEEA IGTFPELLLA GVDTTSNTLT WALYHLSKNP EIQEALHKEV
361 VGVVPFGKVP QQKDFAHMPL LKAVIKETLR LYPVV
CYP27A1 rabbit
PIR A90152 (21 amino acids)
Dahlbaeck, H.
Characterization of the liver mitochondrial cytochrome P-450
catalyzing the 26-hydroxylation of 5beta-cholestane-3alpha,
7alpha,12alpha-triol.
Biochem. Biophys. Res. Commun. 157, 30-36 (1988)
PIR A90155 (21 amino acids)
Dahlbaeck, H.
Biochem. Biophys. Res. Commun. (1989) 159:370
CYP27A1 pig
no accession number
Kjell Wikvall
77% identical to human
CYP27A1 Monodelphis domestica (gray short-tailed opossum)
EF601083
EQLLRQEGKHPLRHDMALWKEHRDSRGFAYGPFTTEGEEWYQLR
QALNSRMLKPSDAALYTDSLNEVIGDLLVQLEDIKAKSLSGDQVPDVANFFYFFALEA
ITYILFEKRIGCLKPPIHPEMETFVKSVGLMFKNSLYVTFLPKWTRPLFPFWNRYLEN
WDIIFTFGKKLIEEKLKDMAAELKDGNSDKIRMSGYLHFLLSSGELTPDEAVGSLAEI
LLAGVDTTSNTMTWALYHLAQDPETQEALYKEVVGVVPPGKIPQYKDFAHMPLLKAVL
KETL
CYP27A1 chicken
XM_422056
COMPLETE 53% TO 27A1 human
N-term is long, may be in error
MAEDLDLPWQTFLPIDIQLPPRWLPESAPRDAQEAKLAASGASP
VLRVTEPPVQFPGKIIDQRAWHESRSPLRHPGRSVSPPVPPSPCLSSDTGAQGAGDER
ACIFSDPSEDTRLQPPIGPEPPCRTGFSPAAAAA
GPARLKGPAELPGPGLLRTFVWLF
LRGYLLHTHRLQLMSRRIYGPIWKSTFVLYQNINIGSPVVLEQLLRQEGKYPMRSDMA
LWKEHRDTRRLPYGPFTEXVRPRSDVGMRIVEPSEAVLYADAIGAVVSDLMVRLRDER
RCSPSGVLVGDVANLLYRFALEGISYILFETRIGCLKQQVPPETQHFIDSINLMFKNS
IFATVLPRWSRKVLPFWDRYLDSWDTIFAFGKRLIDRKMKELEGHVEKGKEVSQGYLS
YLLASGHLSLDEVYGSVAELLLAGVDTTSNTLCWALYHLSRDLGIQDTLYQELKAVVP
PDRFPGAEDIPKMPMLRAVIKETLRVYPVVPTNARVFYEKDIVIGDYLFPKNTLFVLA
HYAMSHDETYFPEPERFLPQRWLRGHGSPHHPFSSIPFGYGVRACVGRRIAELEMHLA
LARIIQAYEVRPDPRGVEVTSVSRIVLVADKPINLEFIARPGAP
CYP27A1X Xenopus tropicalis (Western clawed frog)
See Xenopus CYP27A8, CYP27A9, CYP27A10 and CYP27A12
CYP27A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_3437
46% to 27A1 human
MWKKGSWLLRPLAWARSCSGGAGRVSTVPASPPNLRFKPRTVEDLPRVSLWELLYRLTFQGFHSHMHELQ (0)
136 ILEKGRYGPIYRNGMNAVSVSTAKLLGEVLRNDDKFPNRGDMSIWKEYRDLRGYGYGPFTE 321 (2)
536 KDERWYNLRAVLNKRMLRPKDALQYGDTIGEVVTDFIRRIYFLRQRSPTGDVVTDLNNELYHFSLE 733 (1)
816 AIASILFETRLGCLEEEIPTGTQDFINAISQMFSNNFQVFLMPKWSRGVLPYWRRYVAGWDGIFSF 1013 (1)
1206 ATRLIDRKMEFIQQHLDNNQNVEGEYLTYLLSNTQMSIKDVYGSVSELLLAGVDT 1370 (0)
1465 TSNTLTWTLHLLSKYPQCQEILFKEVSTSVPADRAPSAEEVTRMPYLRAVVKESLR 1632 (2)
1756 MFPVIPMNGRILADKDVMIGGYQFSKN 1836 (0)
1949 TAFNFSHYAIGRDEDTFPEPATFMPERWLQDSHNRPNAFGAIAFGFGVRGCVGRRIAELEMYSFLCH 2149 (0)
2308 LMRHFEIKPDPKMGELKSVCRTVLIPDKPVSLRFLDRGSGHAA* 2439
CYP27A1 Tetraodon nigroviridis (Green puffer)
chr2:17054633-17057366 at UCSC browser
One frameshift at &
Adjacent to BCS1L and ZNF142 as in humans
84% to CYP27A1 fugu
MWWKGSRLLPRPLVGPRVYSREAGQVFTAPTPPSKPRTLEDLPRVSLWELLYRLTIQGFHSRTHELQ (0)
ILEKERHGPIYRNGMKAVSICTATLLEEVLRNDDKFPNRGDMSIWKEYRDL
RGYGYGPFTE (2)
NEDRWYNLRVVLNKRMLHPRDALQYGGTLSEVVTDFIGRIYLLRQRT &
PTGDVVADLNNELYRFSLE (1)
AIASILFETRLGCLEEKIPTGTQDFISAISQMFSNNLQVFLMPRWSRGLLPYWRRYVAGWDGIFSF (1)
ATKLIDRKMEFIQQRLDDNQNVEGEYLTYLLANAQMSIKDVYGSISELLLAGVDT (0)
TSNCLTWTLHLLSEYPQCQEILFKEVSTSVPAGRAPSAEEVTKMPYLRAVVKESLR (2)
MFPVVPMNGRVVADRDVMIGGYHFSKN (0)
TAFNFSHYAISRDEHTFPEAARFLPERWLRDGHRRGGPNAFGTIPFGFGVRGCVGRRIAELEMYLFLFH (0)
LMRHFEIKPDPQMGELKSICRTVLIPDKPLSLYFLDRRSGHAA*
CYP27A2 Fugu rubripes (pufferfish)
chrUn:122717928-122721737 on UCSC browser
or Scaffold_697
41% to 27A1 mouse, 49% to 27A3 Fugu, 42% to 27A1 Fugu
38% to 27C1 Fugu
adjacent to MAP3K2 and SUMO1
note: MAP3K2 is next to ERCC3 in humans that is adjacent to CYP27C1
Fugu 27C1 is adjacent to ERCC3
Therefore CYP27A2 and CYP27C1 had a common origin
29906 MASFTALRCAAIGARNSALRPATLPSRNLNLQATSEAANLKGIADLPGPNTYKILYWLFVKGYGERSHLLQ 30118 (0)
30735 GKLKNIYGPMWRWKLGPYDFVSVASPELIARVIQQEGRYPVRVQLPHWKEYRDLRGQAYGLHVE 30926 (2)
31027 TGPEWSRLRSALNPRMLKLREVVAFSPVIHEVVGDLLRRIEFLRSGSQDGVTVSDIASELYKFGFE (1)
31334 GISAILFETRLGCLGEKVDPNVQRFISGVNDMLSLSDITYLFPRWTRSFVPVWKRFAQAWDDISDV 31531 (1)
31614 ASSLIDRRIAEIDARVANGQSVEGLYLTYLLSSDKMSRAEISTCITDLLLGGVDT 31778 (0)
32763 TSNTLSWALYHLAKDPVAQDRLYDEVNSVCPNHHQPTTDDLANMPFLKAVIKEVLR 32930 (2)
33004 LYPVVHQNARFISENDVILNDYWFPKK (0)
TQFHLCHYSVCHDETQFKHAERFLPERWLRHSAPLSGYYQHHPYSFIPFGVGVRACVGKRVAELEMYFALTR (0)
LMQSYNVQLEDDTMVVEPRTRTLLIPSKPINLRFLRRPGEQRC*
CYP27A2P Tetraodon nigroviridis (freshwater pufferfish)
GSCT00017845001_prot length=460
chr3:953742-956387 UCSC browser
adjacent to MAP3K2 and SUMO1
frameshift and 11 aa deletion at &1
frameshift at &2
73% to CYP27A2 Fugu
note in zebrafish, MAP3K2 is adjacent to CYP27C1, ERCC3
MASVAALRSAPIRPRARFPAALPRKELNLQATTRPAGLKGLEDLPGPGLG
RVLSWLFAEGYAEKSHLLQAQLRSLYGPMWRWTLGPYDLVGVAAPELIAG
IIQQEGRYPLRAPLPHWKDYRDLRGQAYGLHVDTGPEWSRLRSALNPKML
KLQEVATFAPVVHSVVGDLLRRLEFLRSGSQDGVTVSDVASELYKFGFEG
ISAILFETRLGCLDQKVDPNVQRFITAIGDMLSTSDFAYLVPRWARSLVP
VWKRFVQAWDDISDVASWLIDKRIAEIEAQVAGGRSVEGLYLTHLLSSNK
LSRAEIYTCITELLLGGVDTTSNTLSWALYHLAQDPGAQQRL &1
GEPTTEDLASMPFLKAVIKEVLR (2)
LYPVVPSNARVITENDVILGGYWFPKG (0)
TLYHLCHYTISHDASQFVHVEKFLPERWLRGGASQSRCYQHHPYSSIPFG
VGVRACLGRRVAD &2
LEMHFALTR (0)
LMQAYEVRLKDETEVVEAKTRTLLVPSKPINLRFLARA*
CYP27A3 Fugu rubripes (pufferfish)
No accession number
Scaffold_6002 Length = 16767
= LGS139924.x1 57% to 27A1 I-helix
= LGS125183.x1 Cyp27a1
First 16 aa and 49-81 supported by EST from AU050037 Paralichthys olivaceus
aa 49 on also supported by AW343479 zebrafish EST
in pufferfish 27A3 is between EAF2 and SLC15A2
these two genes are adjacent in humans but 27A3 is gone.
MFRNRLLTVGLRASVPHREGLHRTAVNYAGARRRHASSAATEITEHNVR
QKTMEDLGGPSFLTTLNWLFLKGYLPKTQQMQ (0)
4619 VEHSKIYGPLWKSKYGPMVVVNVASADLIEQVLRQEGRHPVRTDMPHWRRYRALRNQAHGPLTE 4428
MGAKWQRIRSILNPRMLKPQHVSSYGITINDVVTDFLEKLVWLRAKDGGGVMVNDVAGELYKFAFE
GISSVLFESRMGCLNDEVPEETQKFIYSVGEMFRLSAVVVLFPQSVWPYLPLWKKFVAAWDYLFKV (1)
1891 AEQMVQKKMEEIQNKVDLHQDVEGAYLTHLLLSEKMTVTEILGSITELLLAGVDT 1715
1661 TSNTISWALYQLAQNPSIQDQLYHEVRSVCPGNKMPDSDDIAQMPYLKAVIRETLR
LYPVVPGNARVTVDKEIVVGGYLFPKQ (0)
754 TLFHLCHYCVSHDENIFPNSRVFQPERWLRGREEKSKQHPFGSVPFGFGVRACLGRRV AELEMYLLLSR (0)
LIRRFEVRPDPNGAEVKPITRTLLCPATPINLQFLDRGAQRAPGPAAGASL*
CYP27A fragment a Fugu rubripes (pufferfish)
No accession number
a = exon 4 of 27A3
LPC42076.x1 39% to 27A1 202-276 79% to LPC42075.x1 gene duplication? Exon 4
GISSVLFESRMGCLNDEVPEETQKFIYSVGEMFRLSAVVVLFPQSVWPYLPLWKKFVAAWDYLFKV
CYP27A fragment b Fugu rubripes (pufferfish)
No accession number
Similar to exon 4 of 27A3
LPC42075.x1 35% to 27A1 79% to LPC42076.x1 gene duplication? Exon 4
GISSVLFESRLGCLNDEVPEETRRVIYSVGEMCRLSAVVVLFPQSGWPYLPVWARLGAAGDYLLQF
CYP27A3 Tetraodon nigroviridis (freshwater pufferfish)
chr2:18232734-18236941 UCSC browser
between EAF2 and SLC15A2
81% to CYP27A3 fugu
MLRSRLLSAGPARQGLRRAAASSAGARPRHAAPASSGVAGGQKTIDDLGGPSFLTTLNWLFVKGFLPKMQQMQ (0)
VEQRKIYGPLWKSKYGPLTVVNVASADLIEQVLRQEGRHPVRTDMPHWRRYRELRNQAHGPLTE (2)
MGAKWLRIRSILNPRMLKPKHVSSYASTINQVVTDFIQRVLWLGAQAGGGVMVHDVAGELYKFAFE (1)
GICSVLFENRMGCLNEEVPEETQKFIFSVGEMFRLSPLVVLFPKYMWPYLPFWKQFVQAWDYLFKV (1)
AEELVHKKMEEIQNKVDLQQSVEGAYLTHLLLSEKMSVTEILGSITELLLAGVDT (0)
TSNTISWSLYQLAQNPDVQERLYQEVSAVCPGDQLPNSDHIAQMPYLKAVIRETLR (2)
LYPVVPGNARVTVDNEIMVGDYLFPKQ (0)
TLFHLCHYCVSHDESVFLNSHAFQPERWLRGTEEKSKQHPFGSVPFGFGVRACLGRRVAELEMYLLLSR (0)
LIRRFEVRPDPAGTEVKPITRTLLCPAKPINLQFLDRGAGQTPRPGAGASPEPL*
CYP27A3 Danio rerio (zebrafish)
NM_001123277
Zv8 chr9:22363585-22376628 100% match
7 aa diffs from our earlier version
MFSNSLLRTGLFLCKQDCSGIKCLTSMFLNARTTSTLIGGDKQKTMDDLDGPSFLTSLY WLFGKGYFQTTHQMQIEHSKIYGPLWKSKYGPLVIVNVASADLIEQVLRQEGRHPIRTD MPHWRGYRKLRNHAYGPLTEMGPEWQRIRSILNPRMLKPKHVSNYTNAINGVVSDFIEK MAKLKTTKGNDVMVYDVAGELYKFAFEGISSVLFETRMGCLNDEIPEETQKFIFSVGEM FRLSPIVILFPKFLWPYMPFWKHFVAVWDHLFKVADELVQQKMTEIQEKVKTGSPVEGE YLTHLLISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHEEVVSV CPGDKTPSSDDITRMPLLKAIVRETLRLYPVVPGNARVVAENEIVVGDHLFPKNTLFHL CHFAVSYDETVFPDPFAFLPQRWIREQKQLSQHPFGSVPFGFGIRACLGRRVAELEMYL LLSRLIKRYEVRPDPSGKTVKPITRTLLVPATSIDLQFIDR
CYP27A3 Danio rerio (zebrafish) [older version]
NP_001116749
4 aa diffs to seq on chr9:16358844-16371887 UCSC browser
EST DR721514.1, DN833321.1, DT066990.1, CD283382.1,
CR928406.1, CD599037.1, DT059155.1
These cover the whole seq with about 2 aa diffs
69% to CYP27A3 Fugu probable ortholog adjacent to EAF2 in both
MFSNSLLRTGLFLCKQDCSGIKCLTSMFLNARTTSTLIGGDKQKTMDDLD
GPSFLTSLYWLFGKGYFQTTHQMQIEHSKIYGPLWKSKYGPLVIVNVASA
DLIEQVLRQEGRHPIRTDMPHWRGYRKLRNHAYGPLTEMGPEWQRIRSIL
NPRMLKPKHVSNYTNAINGVVSDFIEKMAKLKTTKGNDVMVYDVAGELYK
FAFEGISSVLFETRMGCLNDEIPEETQKFIFSVGEMFRLSPIVILFPKFL
WPYMPFWKHFVAVWDHLFKVADELVQQKMTEIQEKVKTGSPVEGEYLTHL
LISEQMSFTEVLGSITELLLAGVDTTSNTISWALYHLAREPEIQQKLHEE
VVSVCPGDKTPSSDDITRMPLLKAIVRETLRLYPVVPGNARVVAENEIVV
GDHLFPKNTLFHLCHFAVSYDETVFPDPFAFLPQRWIREQKQLSQHPFGS
VPFGFGIRACLGRRVAELEMYLLLSRLIKRYEVRPDPSGKTVKPITRTLL
VPATSIDLQFIDR
CYP27A3 Oryzias latipes (medaka)
chr21:6587265-6596897 UCSC browser
adjacent to EAF2
MLRRPLLTATKRGASLLPRDDATKVAAAAGGAPSMLLAELRRHQTSPAVGVDKVKT
LDDLGGPSFLTTLNWLFLKGYFKKTQQLQ (0)
IEHRNIYGPIWKSKYGPLVVVNVASADLIEQVLRQEGKYPVRSQMPHWRSYRELRSKSHGPLTE (2)
LGAKWQRIRSILNPRMLKPVHVSSYTNTLNDVVTDFIERISWLRATGDQGITVNDLTGELYKFAFE (1)
GICSVLFEARMGCMNEVVPEETQKFIFSVGEMFRLSPIVVLFPKVFWPYLPAWKQFVATWDHLFSV (1)
AEDLVKKKMEEIQQDVETNKEVEGAYLTHLLLSDQMTVTEILGSMTELLLAGVDT (0)
TSNTISWALYHLAKEPEIQTKLYREVIDVCPGDKVPTSSDISQMPYLKAVIRETLR (2)
LYPVVPSNARVTVENDIIVGGYVFQKQ (0)
TLFHLCHYAVSHDESIFPDPHTFLPQRWLRGLDDKIKQHPFGSVPFGFGVRACLGRRVAELEMYLLLSR (0)
LLKSYEVRPDPAGTEVKPITRTLLCPAEPINLQFLDRKA*
CYP27A3 Gasterosteus aculeatus (three-spined stickleback)
chrUn:42545325-42552979 UCSC browser
adjacent to EAF2
note EAF2 and SLC15A2 are present in lizard
but no CYP27A3 is between them (lost on the way to tetrapods)
MLSRSTASLGLRLQRNATRSLLAALSPGPHGG
RHASASTSSTVTAHSSPLKTMEQLGGPGLLTTLNWLFVKGYFQTTQQMQ (0)
IEHSRIYGPLWKSKYGPLVVVNVASAQLIEQVLRQEGRLPVRTDMPHWRSYRELRNQAHGPLTE
MGVKWQRIRSILNPRMLKPKHVSSYACTINEVVGDFVRRAAWLRETGGGGLMVNDLTAELYKFAFE
GICSVLFETRMGCMNEVVPEETQKFIFSVGEMFRLSPILVLFPKSFWPYTPFWKQFVAAWDHLFKV
VAEELVQQKMDEIQEKVHLDQSVEGAYLTHLLLSEQMTVTEILGSITELLLAGVDT
TSNTIAWALYQLAKQPEIQEQLYQEVIGVCPGDKVPSSEDIAQMPLLKAIIRETLR
MYPVVPGNARVSVESEIVVGDHLFPKN
TLFHLCHYAVSYDESIFPDAHSFLPDRWLRGGEDKPRLHPFGSVPFGFGIRACLGRRVA ELEMYLLLSR
LMQRFEVRPDPAGAPVKPITRTLLCPATPINLQFVDRRPSLC*
CYP27A3 Osmerus mordax (Rainbow Smelt)
EL545126 EST
75% to 27A3 zebrafish N-term
MIGKCLLKIGLRACSQENCGIIRVTTTLNNVRDMRRGSSTAA
TTVIAGNDKQKTMDDLDGPSFMTSLYWLFGKGYFQTTQQLQIEHSKIYGPLWKSKYGPLV
IVNVASAELIEQVLRQEGRHPVRTDMPHWRAYRELRNQAYGPLTEMGAKWQRIRSILNPR
MLKPKHVSAYTNAINEVVTDFIDKVAWLRDTRGGGVMVNDLSGELYKFAFEGICSVLFET
RMGCLNEKVPEETQKFIFSVGEMFRLSPIVILFPKSVWPYLPFWKHFVVVWDHLFKIAEE
LVH
CYP27A4 Danio rerio (zebrafish)
BX321915.3, BC055637 60% to 27A1 fugu
Temp name CYP27A.d
2 aa diffs to chr9:32649613-32658960 UCSC browser
65501 MAVCFALSSAERLGIGLGFLRPTAAATGFRRAAGNAAAASVSVQDGHRK
LKTEADLPEIKIFTMLYRLLFKGYLSRMHELQ (0)
LYEKQLYGPLYKINVGNFQSVALNSVDLLEELLRKDEKFPSRGDMTLWTEYRDMKGIGYGPFTE
EGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNKLYRFSLE
GISSILFETRIGCLEKEIPAETQHFINSIAQMLTYSMPVVFMPNWTRNYLPFWQRYIGGWDGIFK
FAGKMIDMKMEALQKRVDANQEVAGEYLTYLLSNGKMSSKDVYGSVSELLLAGVDT
TSNTMLFALYHLSKDPETQDILYQEVTNVLKDDRIPTAQEVNTMSYLKAVIKETLR
LYPVVPMNARLIAENEVVIGGHLFPKN (0)
TTFTLCHYAISRDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRGCVGRRIAELEMYLALAR
LIKLFEIRPDPTVGEVRSLNRTVLAPDRKVNLHLVERKKTEA* 56151
CYP27A5 Danio rerio (zebrafish)
BX321915.3
Temp name CYP27A.c
100% to chr9:32660646-32665857
59% to 27A1 fugu
54468 MAVCFALSSAERLGWCFLRPTAAATGFRSAAGNAAAASVSVQDGHRKLKTEADLPEI 54298
54297 KIFTMLYQMLFKGYLNSVHELQ 54232 (0)
LYQKQVYGPLWKINAGNLQGISISSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGISYGPFTE 53897 ()
EGEKWYKLRAVLNKRMLHPKDSVQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLE
XIASILFETRIGCLEKEIPAETQKFINFIAQMFTYSMHVALLPNWTRKYFPFWQKYIDGWDGIFKF
GTKMIDMKMEAIQKRVDTNQDVAGEYLTYLLSNGKISRKDVYGSVSELLLAGVDS
TSNTMLWALYLLSKDPEAQETLYQEVTKVLKDDRIPTAEEVNSMPFLKAVIKETLR
LYPVVPVNSRLIAETEVVIGEYFFPKK (0)
TTFTLCHYVISRDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALAR
LIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVERQKTET* 49254
CYP27A6 Danio rerio (zebrafish)
BX321915.3
Temp name CYP27A.b
100% to chr9:32668191-32674283 (+)
61% to 27A1 fugu
46923 MAVCFALSSAERLGFGFLRPTAAATGFRRAAGNAAAASVSVQDGHRKLKTEA 46768
46767 DLPEIKIFTMLYQMLFKGYLNSIHELQ 46687 (0)
46408 IYQKQVYGPLSKINSGNLQGISISSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGIGYGPFTE 46217 ()
EGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLE
XIASILFETRIGCLEKEIPVETQEFINSIAQMFTYSMHVALLPNWTRNYFPFWQKYIDGWDGIFKF
GTKMIDMKMEAIQKRVDTNQEVAGEYLTYLLSSGKMSSKDVYGSVSELLLAGVDT 1183
TSNTMLWALYLLSKDPAAQETLYQEVTKVLKDDRIPTAEEVNSMPFLKAVIKETLR 1000
LYPVVPVNSRLIAETEVVIGEYFFPKK (0)
TTFNLCHYAISHDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALAR
40957 LIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVERQKTET* 40849
CYP27A7 Danio rerio (zebrafish)
BX321915.3
Temp name CYP27A.a
100% to UCSC browser chr9 32687123-32697779 (+) strand
59% to 27A1 fugu zfishG-a34c11.p1c
28992 MAVSFALSSAERLGWCFLRPTTAATGFRRAAGNSAAASVSVQDGHRKLKTEA 27837
27836 DLPEIKIFTMLYQMLFKGYLNSVHELQ 27756 (0)
25958 LYQKQVYGPLWKINAGNLQGISITSVELLEELLRKDEKYPCRGYMTLWTEHRDLRGISYGPFTE 25767 ()
EGEKWYKLRAVLNKRMLHPKDSLQYGDVVNAVITDFIKRIYYLREMSPTGDLVSNLTNELYRFSLE
GIASILFETRIGCLEKEIPAETQEFINSIAQMFTYNMHVALLPNWTRNYLPFWQKYIDGWDGIFKF
GTKMINLKMEAIQTRLDTNQEVAGEYLTYLLSSGKMSCKDVYGSVSEVLLAGVDT
TSNTMLWALYLLSKDPAAQETLHQEVTKVLKGDRIPTAEEVNSMPFLKAVIKETLR
LYPVVPVNSRLIAESEVIIGEYLFPKK (0)
TTFNLFHYAISHDEKVFPEPQKFKPERWLRDGRTRPNPFGSIPFGFGVRACVGRRIAELEMHLALAR
LIKLFEMRPDPTVGEVKANFRSVLVPNKKVNLHFVERQKTET* 17333
CYP27A8-de4b5b Xenopus tropicalis (Western clawed frog)
pseudogene
exons 4 and 5 only
scaffold_77:1644664-1645797 (-) strand UCSC browser
FETRIGCLDKQIPPETQKFIDSIGYMFKNSVYVTFLPHWTRGILPYWDRYIEGWDNIFDFGKR
LIDKKMSEIQSRLDKGEEVEGEYLTYLLSSANLTMGEVYGSVCELLLAGVDT
CYP27A8 Xenopus tropicalis (Western clawed frog)
DR832386.1 CX969640.1 DR852196.1
scaffold 77 1626758-1638467 (-) strand UCSC Browser
old CYP27A1 Xenopus
best X.tropicalis hit to CYP27A1 hum in ESTdb
best match in human = CYP27A1 55%,
probably a CYP27A1 ortholog
scaffold_77:1626758-1638467 (-) complete in UCSC browser
Trace archive 570051728(+), walked to 411568263(+) 494948503(+)
54% to 27A7 zebrafish, 50% to 27A3 zebrafish, 50% to 27A1 human
this seq is near BCS1L and ZNF142 like human CYP27A1
MPSASKLGFLPLGRCRWLLHTGRGVSVSQGRAVAGAAVGAVGEEKKMKTF
EDLPGPSLLTNIYWVFLRGYILYTHELQAIYKKNYGPMWKST
LGRYKTVNIADVDILETVLRQEGKYPMRSDMEVWKEHRRQRDLSLGPFTEEGHKWHTLRS
VLNKRMLKPAEAMLYTGVVNEVVTDFLVRLEEMRSETPSGDMVNDIPNALYRFAFEGISY
ILFETRIGCLEKQIPVETQRFIDSIGAMLKNSIFVTIFPPWTNNLLPYYKRYMDSWDNIF
AFGNKLINEKMKKIEARLERDEEVQGEYLTYLISSGKLTDKEIYGSVAELLLAGVDTTSN
TLSWALYHLAREPEIQNALYQEVIGVVPGQNIPTSEDISSMPLLRAVIKETLR
LYPVVPTNSRVAVEKAITIGDYYFPKD
TLIALHHYHISRDEKNFPESDKFIPQRWFRESRVKNNPFSSIPFGYGVRACVGRRI AELEMHMCLSR ()
IIKKYEVRPDPSGAEIKSMARIVLTPHKPINLRFLPR
CYP27A9 Xenopus tropicalis (Western clawed frog)
AL787054.2 DT421274.1 CR427561.1 BC094536.1
note there are three adjacent CYP27A genes in Xenopus
50% to 27A1 human, 42% to 27B1 human and 38% to 27C1 human
52% to 27A5 zebrafish, 51% to 27A3 zebrafish
scaffold_77:1590575-1599619 (-) strand, 11 aa diffs in first half
exon 6 missing in genome assembly
MRKGCHALLWKTCWANVQTGRE
KATLGVAGAVAEQEKKLKMSTDLPGPSTLNILYWVFLRGYVFESHKLQVIWKKRYGPLW
KTCIGSHRLVNVASPELLETLLRQEGKYPMRTDMFMWKEHRDLQDFSYGPLTEEGHRWHT
LRRVLNQRMLKPKEAVRYTESFNDVVTDLLVVIKEITAQSPNRTTVDGVANLMYKFAFES
ICTVLFETRIGCLKKEIPPETEKFINSIAIMLENQTRMEKLPRWTRGIFPYWRRFVEGWD
NIFIYGKKLIDKKMEEIEGRLKRGEEVEGEYLTYLLSSGKLSMEEICGSVAELLQAGVDTTSNT
LTWALYQLARNPEIQHNLHQEVIGVTPGDTIPDSEAIARMPLLRAVIKETLRLYPVVPEN
GRVVTEKDVILNDYIIPKNSQFVLCHYALSRDETQFPEPDRFLPERWLR
DSGMKHHPFSSIPFGYGVRACAGRRIAELEMHLALSRIIKMFQVVPDPELGEVGTKNRTV
LVSSRPINLQFIER*
CYP27A10 Xenopus tropicalis (Western clawed frog)
CX393015 DR862140.1 DN030991.1
49% to 27A1 human
scaffold_31:1,728,368-1,736,213 19854_prot UCSC browser
scaffold_77:1580461-1588306 (-) strand complete in UCSC browser
53% to 27A7 zebrafish, 48% to 27A3 zebrafish
MIAQRLQTGA
QALLQQSCRASVQTVRKKATLGVSGATVVEGKTLKTLDDLPGPSPLKLLYWIFLRGYLFR
THELQVIFRKTYGPMWKMSDRQHAMVTVASPDLLESLLRKEGKYPTRADMFIMREHRDLR
GHSYGPVTEEGHQWHRIRTILNQRMLKPRETVVYAGSMNEVVSDLLLKIKELTAQSSSGT
QVNGVAELMYKFAFESICTVLFETRLGCLNKEILPETQKFIDSIGIMLEHLTMLTRLPQW
TKGILPYWGRYIEAWDTIFDFGKKLIDKKMEDIEGRLKRGEEVEGEYLTYLLSSGKLSME
EVYGSVVELLQAGVDTTSN
TLTWALYQLSRNPEIQNNLYQEVIRVIPGETIPDSEAIARMPLLKAVIKETLRL
FPVVPENARMINEKEVTIKDYVFPVKTQFILGHYAISRDETTFPEADRF
LPERWLRDSGMKHHPFGSIPFGYGVRACVGRRIAELEMHLALSRIIKMFQVIPDPDLGEV GAKNRAVLVANRPVNLRFIERQPRPE*
CYP27A11 Petromyzon marinus (Lamprey)
Contig1559:9792-24354 at UCSC browser, EST FD706879.1
adjacent to RQCD1 which is near CYP27A1 human
(about 7 genes away)
This is probably the ortholog of CYP27A1
51% to 27A3 zebrafish, 46% to 27A1 human, 48% to 27A5, 27A6 zebrafish
MAAWWTRVTRLRPLSLLLRAAPPGFARVAGTETRSRSWTETRAETRALRWAH
GSVAPVAAPVAAPRGAEHSRSPDELTGPSFFTIIYWVLCRNNNAHLLQ (0)
VECKNRYGPMWKSKFGPYMVISVADADLIEQVIRQEGKYPIRFDMKNW
TDYRDLRGYAYGPFTE
NGSKWNQLRSVLNQKMLRPRDMVAYVKPINEVVTDLLARLHMLSASNGGMVNNLANEFYKFAFEGTEAIL
FEKRLGCLEQSVPEETQVFIDAVRTVFIHSEKMALIPKWIRMILP
LWKHYCNAWDVIFSF
GMKEIDKKMIKISEMVARGEPVEGEYLTYLLSNGKLTEHEIHGSIAELLMAGIDT (0)
TSNTMSWVLYHLSREPHLQERLHQEVEGVCPGNTIPNVQDLAKMSFLKAVIKEILR (2)
LYPVVPSNSRLIVEGGTKVGGYVFPKG ()
TLFQLCHYAVSHNPEIFPDPEAFKPERWLRKGTMLAHPPFGSIPFGFGVRACVGRRVAELEMYLTLSR ()
LIKEFEVQWDPSQKDILPKTSTVIIPSESINLKFIARK
CYP27A12 Xenopus tropicalis (Western clawed frog)
SwissProt B1H1B1
scaffold 77 1642228-1648152 (-) strand
66% TO CYP27A8
MGSRGSLLLQAGRV
AVRQTRAAAGGPSRLGCLPQGRGCGLVQAGRGASVSQGRAVTGAAVGATEGRKEMKEFE
DLPGPSLLKNLYYYFLRGYLLHTHELQLIYKKMYGPLWRSEIGKYKMVNIADPEVLQRL
VRQEGKYPMRNKEDVWKAHRDKRKLAYGPFTEEGHQWYQIRSALNKKMLKPSEAASYAG
GINEVVTDFMDRLQDMRKASPSGDMVNDLANALYRFAFEGISNIVFETRIGCLDKQIPP
ETQKFIDSIGYMFKNSVYVTFLPHWTRGILPYWDRYIEGWDNIFDFGKHLIDKKMSEIQ
SRLDKGEEVEGEYLTYLLSSANLTMGEVYGSVCELLLAGVDTTSNTLCWAMYHLARDPE
LQQAVYEEVSSAAPMDRIPVAEDIPNMPLLRGVIKETLRLYPVIPTNARIVSEKEVEIG
EYRFPKNTLFVLSHYAIARDEENFEDPLKFKPQRWLRDGGMKHHPFSSIPFGYGVRACL
GKRIAELEMHLALSRVIRMFELRWDPKGEDIKSIARIVLSPSKPVNLQFLERKTHQE*
CYP27A12 Xenopus laevis (African clawed frog)
SwissProt Q6DE36
56% CYP27A13av1, 86% to CYP27A12 X. tropicalis (ortholog)
MSRGGLLLKTCRVAVSQGRAVTGGPPASRLHCVPQGSGYLQAGRGVSVSQGRAVTGAAV
ETADGRKEMKEFDDLPGPSLLKNLYYYFVRGYLLHTHELQLNYKKMYGPLWRSEIGKYK
MVNIGDPEALQQLLRQEGKYPMRNKEDIWKAHRDQRKLAYGPFTEEGYHWYRIRSVLNK
KMLKPSEASSYAGGINEVVTDFMNKLQYMRKASPSGDMVNDVANALYRFAFEGISNILF
ETRIGCLEKQTPPETQKFIDSIGYMFKNSVYVTFLPQWTKGILPYWDRYIEGWDNIFDF
GKQLVDKKMSEIQSRLDRGEEVEGEYLTYLLSSANLNIGEVYGSVCELLLAGVDTTSNT
LCWSMYHLARDPELQQAVYEEVSSAVPMDRIPVAEDISKMPLLRGVIKETLRLYPVVPT
NGRIVSEKDVKIGEYRFPKNTLFVLCHFAIARDEENFEDPLKFQPQRWLRDGGMKHHPF
SSIPFGYGVRACVGKRIAQLEMHLALSRIIRIFELRPDPKGGDIKTIARILLTPNKPVN
LQFLERNAHQG
CYP27A13av1 Xenopus laevis (African clawed frog)
SwissProt A8E5X9, GenEMBL EB474537.1
6 aa diffs to composite 93% to CYP27A13b
IFFGIIDRIRPDSS
RLRTGAQALLQQSWQANVQIVRKKTTLGVSGATVVEKKTLKTLDDLPGPNSLKAFYWI FLRGYLFRTHELQVLFKKTYGPMWKISDGQQDMVYVACPDVLESVLRNEGKYPTRRDMF IMKEHRDLRGHSYGPVTEEGHQWHRLRTVLNQRMLKPKESMVYAESMNQVVSDLLVKIK EITAQSSSGTTVNGVADLMYRFAFESICTVLFETRIGCLNKEILPETQKFIDSIGNMLK YLTVVMRLPQWTKGILPYWGRYIEAWDTIFEYGRKLIDNKMKEIDDRLKRGEEVEGEYL TYLLSSGKLSMKEIYGSVGEMLQGGVDTTSNTLTWALYQLSRNPEIQNNLYQEVISVIP GETTPNSEAFARMPLLKAVIKETLRLYPVVPENARMINEKEVIINDYVFPVMTQFVLGH YVIAQDETTFPEADRFLPERWLRESGIKHHPFGSIPFGYGVRACVGRRIAELEMQLALS RIIKMFKVIPDPDLGEVRAINRSTLVPNQPVNLQFIERQRPE
CYP27A13av2 Xenopus laevis (African clawed frog)
SwissProt Q32NH3
4 aa diffs to CYP27A13av1
84% to CYP27A10 (ortholog?)
QRLRTGAQALLQQSCQANVQIMRKKTTLGVSGATVVEKKTLKTLDDLPGPNSLKVFYWI FLRGYLFRTHEIQVLFKKTYGPMWKISDGQQDMVYVACPDVLESVLRNEGKYPTRRDMF IMKEHRDLRGHSYGPVTEEGHQWHRLRTVLNQRMLKPKESMVYAESMNQVVSDLLVKIK EITAQSSSGTTVNGVADLMYRFAFESICTVLFETRIGCLNKEILPETQKFIDSIGNMLK YLTVVMRLPQWTKGILPYWGRYIEAWDTIFEYGRKLIDNKMKEIDDRLKRGEEVEGEYL TYLLSSGKLSMKEIYGSVGEMLQGGVDTTSNTLTWALYQLSRNPEIQNNLYQEVISVIP GETTPNSEAFARMPLLKAVIKETLRLYPVVPENARMINEKEVIINDYVFPVMTQFVLGH YVIAQDETTFPEADRFLPERWLRESGIKHHPFGSIPFGYGVRACVGRRIAELEMQLALS RIIKMFKVIPDPDLGEVRAINRSTLVPNQPVNLQFIERQRPE
CYP27A13 composite seq. Xenopus laevis (African clawed frog)
BG554727 dac30e04.y1 BG731192 dae11g03.y1
BG345818 dg41f04.y1 BG023437 dg41f04.x1 BG348981 daa35e09.x1
BG552024 dae12f10.x1
BG515454 dae07h01.y1 BG731762 dac30e04.x1
46% to 27A1 39% to 27B1 35% to 27C1 so this is a 27A homolog
MAGQCTNCAKKDTLGVSGATVVEKKTLKTLD 196
6 DLPGPNSLKAFYWIFLRGYLFRTHELQVLFKKTYGPMWKISDGQQDMVYVACPDVLESVL 182
183 RNEGKYPTRRDMFIMKEHRDLRGHSYGPVTEEGHQWHRLRTVLNQRMLKPKESMVYAESM 362
363 NQVVSDLLVKIKEITAQSSSGTTVNGVADLMYRFAFESICTVLFETRIG 506
191 CLNKEILPETQKFIDSIGNMLKYLTVVMRLPQWTKGILPYWGRYIEAWDTIFEYGRKLID 370
371 NKMKEIDDRLKRGEEVEGEYLTYLLSSGKLSMKEIYGSVGEMLQGGVD
207 TTSNTLTWALYQLSRNPEIQNNLYQEVISVIPGETTPNSEAFARMPLLKAVIKE 368
369 TLRLYPVVPENARMINEKEVIINDYVFP 452
VMTQLFLGHYVIAQDETTFPEADRFLPERWLRESGIKHHPFGSIPFGYGVRACV 470
GRRIAELEMQLALSRIIKMFKVIPDPDLGEVGAINRATLVPNRPVNLQFIERQRPE*
CYP27A13b Xenopus laevis (African clawed frog)
SwissProt A1A609
93% to the composite seq., 85% to CYP27A10
presumed ohnolog to CYP27A13a
QRLRTGAQALLQQSCQANVQTVRKKTTLGVSGATVSEKKTLKTLDDLPGPNSLKALYWI
FLRGYLFRTHELQVIFKKTYGPMWKLSDGQQQTVNVASPEILESVLRKEGKYPTRGYMF
IMREHRDLRGHSYGPVTEEGHQWHRLRTVLNQRMLKPKESMVYAESMNQVVSDLLVKIK
EITAQSSSGTTVNGVADLMYRFAFESICTVLFETRIGCLNKEILPETQKFIDSIGNMLK
YLTVVMRLPQWTKGILPYWGRYIEAWDTIFEYGKKLIDNKMKEIDDRLKRGEEVEGEYL
TYLLSSGKLSMKEIYGSVGEMLQGGVDTTSNTLTWALYQLSRNPEIQNNLYQEVIRVIP
GETTPSNEAIARMPLLKAVIKETLRLYPVVPQNARMINEKEVIINDYVFPVMTQFVLAH
YAIARDETTFPEPDRFLPERWLRDSGIKHHPFGSIPFGYGVRACAGRRIAELEMQLALS
RVRNVQ
27B Subfamily
CYP27B1 rat
GenEMBL AF000139
St-Arnaud,R., Messerlian,S., Moir,J.M., Omdahl,J.L. and
Glorieux,F.H.
The 25-hydroxyvitamin D 1-alpha-hydroxylase gene maps to the
pseudovitamin D-deficiency rickets (PDDR) disease locus
J. Bone Miner. Res. 12, 1552-1559 (1997)
previously named CYP40. This sequence has errors in it.
CYP27B1 rat
GenEMBL AB001992
Cloning and expression of rat 25-hydroxyvitamin D3-1-alpha-
hydroxylase cDNA .
Shinki, T., Shimada, H., Wakino, S., Anazawa, H., Hayashi, M.,
Saruta, T., DeLuca, H.F. and Suda, T.
Proc. Natl. Acad. Sci. USA 94, 12920-12925 (1997)
Note: this sequence has been called CYP27B1 in this paper. The name
CYP40 was
given in May 1997 based on the sequence from John Omdahl that was
not
completely accurate at the time of submission for a name. It was
necessary to
revise the name CYP40 to CYP27B1.
CYP27B1 mouse
GenEMBL AB006034
Takeyama, K-i., Kitanaka, S., Sato, T., Kobori, M., Yanagisawa, J. and
Kato, S.
25-hydroxyvitamin D3 1 alpha hydroxylase and vitamin D synthesis.
Science 227, 1827-1830 (1997)
Cyp27b1 mouse
GenEMBL AB006034 AC084293.2 Mm.6216
LEADSPNTDMTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLR
SLSDIPGPSTLSFLAELFCKGGLSRLHELQVHGAARYGPIWSGSFGTLRTVYVADPTL
VEQLLRQESHCPERCSFSSWAEHRRRHQRACGLLTADGEEWQRLRSLLAPLLLRPQAA
AGYAGTLDNVVRDLVRRLRRQRGRGSGLPGLVLDVAGEFYKFGLESIGAVLLGSRLGC
LEAEVPPDTETFIHAVGSVFVSTLLTMAMPNWLHHLIPGPWARLCRDWDQMFAFAQRH
VELREGEAAMRNQGKPEEDMPSGHHLTHFLFREKVSVQSIVGNVTELLLAGVDTVSNT
LSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHGTALSQLPLLKAVIKEVLRLYPVV
PGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQFPDPNSFNPARWLGEGPTPHP
FASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPEPGALPIKPMTRTVLVPERS
INLQFVDR
The mouse and probably rat have lost 27C1 due to a chromosome rearrangement between BIN1 and ERCC3
It seems that 27C1 was broken and lost in this event.
In fugu CYP27C1 is on the minus strand of scaffold 106 from 31916-36680 the
neigboring gene, 2624 bp away, is ercc3 at 39305-43553 minus strand (also found in human 39kb away)
Therefore, this linkage is very old. The next gene in the series ERCC3, CYP27C1 is BIN1 in human.
In mouse chr 1 is syntenic to human chr 2 at ERCC3, but BIN1 is on chr 18, implying a chromosome break.
CYP27B1 human
GenEMBL AB005989 cDNA sequence
Takeyama,K., Kitanaka,S., Sato,T., Kobori,M., Yanagisawa,J. and
Kato,S.
25-Hydroxyvitamin D3 1alpha-hydroxylase and vitamin D synthesis
Science 277, 1827-1830 (1997)
CYP27B1 human
GenEMBL AB005990 gene sequence
Murayama,A., Kitanaka,S., Takeyama,K. and Kato,S.
Human 25-hydroxyvitamin D3 1alpha-hydroxylase gene
Unpublished (1997)
CYP27B1 human
GenEMBL AB005038 cDNA sequence AB006987 gene sequence
Monkawa,T., Yoshida,T., Wakino,S., Shinki,T., Anazawa,H.,
Deluca,H.F., Suda,T., Hayashi,M. and Saruta,T.
Molecular cloning of cDNA and genomic DNA for human
25-hydroxyvitamin D3 1alpha-hydroxylase
Biochem. Biophys. Res. Commun. 239, 527-533 (1997)
CYP27B1 human
GenEMBL AF020192 cDNA sequence
Fu,G.K., Lin,D., Zhang,M.Y., Bikle,D.D., Shackleton,C.H.,
Miller,W.L. and Portale,A.A.
Cloning of human 25-hydroxyvitamin D-1alpha-hydroxylase and
mutations causing vitamin D-dependent rickets type 1
Mol. Endocrinol. 11, 1961-1970 (1997)
CYP27B1 human
GenEMBL AF0027152 gene sequence
Fu,G.K., Portale,A.A. and Miller,W.L.
Complete structure of the human gene for the vitamin D 1alpha-
hydroxylase,
P450c1alpha.
DNA Cell Biol. 16, 1499-1507 (1997)
CYP27B1 human
NM_000785
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPS
TPSFLAELFCKGGLSRLHELQVQGAAHFGPVWLASFGTVRTVYVAAPALVEELLRQEG
PRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNN
VVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDT
ETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAA
MRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELS
RHPEVQTALHSEITAALSPGSSAYPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPD
KDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGF
GKRSCMGRRLAELELQMALAQ
ILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
CYP27B1 Pan troglodytes (chimpanzee)
XM_509175.3
99% (2 aa diffs) to human
MTQTLKYASRVFHRVRWAPELGASLGYREYHSARRSLADIPGPS TPSFLAELFCKGGLSRLHELQVQGAARFGPVWLASFGTVRTVYVAAPALVEELLRQEG PRPERCSFSPWTEHRRCRQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLNN VVCDLVRRLRRQRGRGTGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAQVPPDT ETFIRAVGSVFVSTLLTMAMPHWLRHLVPGPWGRLCRDWDQMFAFAQRHVERREAEAA MRNGGQPEKDLESGAHLTHFLFREELPAQSILGNVTELLLAGVDTVSNTLSWALYELS RHPEVQTALHSEITAALSPGSSAYPPATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPD KDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGF GKRSCMGRRLAELELQMALAQILTHFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR
CYP27B1 Bos taurus (cow)
See cattle page for details
MTQTLKFASRVFHRVRCPELGASLGSRGSESAPRVLADIPGPSTPGFLAELFCKGGLSRLHELQ (0)
VQGAARFGPVWLASFGTVRTVYLAAPTLVEQLLRQEGPRPERCSFSPWTEHRRRRQRACGLLTA (2)
EGEEWQRLRSLLAPLLLRPQAAARYAGTLHGVVRDLVRRLRRQRGLGAGPPSLVRDVAGEFYKFGLE (1)
GIAAVLLGSRLGCLEAEVPPDTETFIRAVGSVFVSTLLTMAMPSWLHRVVPGPWDRLCRDWDQMFAF (1)
AQQHVEQREAEVAMRNQSEKSEEDMGPGAHLTYFLLQKELPAASILGNVTELLLAGVDT (0)
VSNTLSWALYELSRHPEIQTALHAEITAALGPGSSTQPSATALSQLPLLKAVVKEVLR (2)
LYPVVPGNSRVPDRDICVGEYIIPKN (0)
TLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPAPHPFASLPFGFGKRSCVGRRLAELELQMALAQ (0)
ILIHFEVQPEPGSAPVRPMTRTVLVPERSINLQFVDR*
CYP27B1 Equus caballus (horse)
NM_001163957
MTQTLKLASRVFHRLRCAPELGTSLGSRGSDSAPRSLADIPGPS
TPGFLAELFCKGGLSRLHELQVQGAARFGPVWLASFGTVRTVYLAAPTLIEQLLRQEG
PRPERCSFSSWAEHRRCSQRACGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLDD
VVRDLVRRLRRQRGRGAGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEAEVPPDT
EAFIRAVGSVFVSTLLTMAMPNWLHRLVPGPWGRLCRDWDQMFAFAQQHVERREAEVA
GRSPGKPEEDMGSGAHLTYFLFREELSASSILGNVTELLLAGVDTVSNTLSWALYELS
RHPEVQTALHSEITAALGPGSNGHHSATALSRLPLLKAVVKEVLRLYPVVPGNSRVPD
RDIHVGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGEGPAPHAFASLPFGF
GKRSCMGRRLAELELQMALAQILIHFEVQPEPGATPIRPMTRTVLVPERSINLQFVDR
CYP27B1 pig
DQ295065
MTQTLKLASRVFHRVCRAPELGSRGSDSAPRGLADLPGPSTPGF
LAELFCKGGLSRLHELQVQGAARFGPVWLASFGKVRTVYVAAPTLVEQLLRQEGPLPE
RCSFSPWTEHRRRRQRSCGLLTAEGEEWQRLRSLLAPLLLRPQAAARYAGTLHDVVQD
LVRRLRSQRGLGAGPPALVRDVAGEFYKFGLEGIAAVLLGSRLGCLEPEVPPDTETFI
RAVGSVFVSTLLTMAMPSWLHRLVPGPWARLCRDWDQMFAFAQEHVERREAEAAMKSQ
GKPEEDLGSGAHLTYFLFREELPAPSILGNVTELLLAGVDTVSNTLSWALYELSRHPE
VQMALHSEIKTALGPSSSAHPSATVLSQLPLLKAVVKEVLRLYPVVPGNSRVPDKDIC
VGDYIIPKNTLVTLCHYATSRDPAQFPEPNSFRPARWLGECPAPHPFASLPFGFGKRS
CMGRRLAELELQMALAQILIHFEVQPEPGSAPIRPMTRTVLVPERSINLQFVDR
CYP27B1 Canis familiaris (dog)
XM_538254.2
88% TO HUMAN CYP27B1
MGLNRGSGKQARCSGEVLSSVASPNQAMTQALKLASRVFHRIHW
APKLGSSLGSRGSDSAPRSLADIPGPSTPVFLAELFCKGGLSRLHELQVQGVARFGPV
WLASFGKVRTVYVAAPALVEQLLRQEGPRPERCSFSPWAEHRRHRQRACGLLTAEGEE
GQRLRSLLAPLLLRPRAAARYAAPLADVVRDLVRRLRQQRGRGAGPPALVRDVAAEFY
KFGLEGTAAVLLGSRLGCLEAQVPPDTDAFIRAVGSVFVSTLLTMAMPGWLHRLVPGP
WGRLCRDWDQMFAFAQQHVERREAEVALRSEGKAAEDVGSGAHLTYFLLREELPAPSI
LGNVTELLLAGVDTVSNTLSWALYELARHPDVQTALHSEITAALGPGSSAHPSAAALS
QLPLLKAVVKEVLRLYPVVPGNSRVPDKDIRVGDYIIPKNTLVTLCHYATSRDPAQFP
EPNSFRPARWLGEGPAPHPFASLPFGFGKRSCMGRRLAELELQMALAQILTHFEVQPE
PGAAPIRPMTRTVLVPERSINLQFVDR
CYP27B1 Xenopus tropicalis (Western clawed frog)
NM_001006906.1
scaffold_67:1250110-1259521 in UCSC browser
this gene is between MARCH9 and METTL1 LIKE human 27B1
54% to human
63% to 27B1 zebrafish, 48% to 27A3 zebrafish, 54% to 27B1 human
MAQTLKLGSSRSSQLFRGLQELWAETVLKNSEKVIKGHKSLADM
PGPSTVSFISDLFCRRGLARLHELQLEGKAKFGPVWKASFGPILTVHVAEPSLIEQVL
RQEGKHPIRSDLSSWKDYRQCRGHSYGLLTAEGEEWQQFRSILGKHMLKPKEVEAYSD
VLNDVVGDLIKKINYQRSQNQNNVVKDIAKEFYMFGLEGISSVLFESRIGCLEPTVPK
ETEKFIQSINTMFVMTLLTMAMPKFLHKIFRKPWQKFCESWDYMFAFAKGHIDKRMKD
VAQKLAQGEKVEGKYLTYYLAQEKIPMKSIYGNVTELLLAGVDTISSTLSWSLYELAQ
HPDIQSAVYSEVEEILQGKQIPSPSDVARMPLLKAVVKEVLRLYPVIPGNARVVADRD
IQVGDYIIPKKTLITLCHYATSRDENVFSNPNEFQPDRWLKKEDTHHPYASLPFGFGK
RSCIGRRIAELEVYLALARILSHFEVKPEQPGSLVMPMTRTLLVPEKEINLQFLER
CYP27B1 Danio rerio (zebrafish)
chr11:1675158-1683318
72% TO 27B1 FUGU
568 MMMVLHQALKVTGRSALPLLRFAERWADVIRAPPTPQVKTLEQMPGPSPARFIRDLFMKRGFS 380
379 RLHQLQ 362 ()
337 LEGRQKYGPMWKASFGPILTVHVAEPELIQQVLRQEGQHPMRSELSSWKDYRALRGEG 164
163 YGLLT 149 ()
158 SEGEEWQCVRSLLSKHMLRPQAVEAYDGALNAVVSDLLQKLKLRSQESSSRIVSDISAEF 337
338 YRFGLEG 358 ()
281 ISSVLFESRIGCLDAVVPVETERFIQSINTMFVMTLLTMAMPQWLHRLLPKPWDTFC 451
452 RCWDVMFEF 478 ()
46 AKGHIDQRLQQEKQKLECGEQLEGRYLTYFLSQAGLPLTSVYSNVTELLLAGVDT 210
592 ISSTLSWSLYELSRHPDVQTALRXEVLSVMKGRRSVPQASDVAAMPLLKAVVKEIL 425 ()
345 RLYPVIPANARVINKDIEVGGYVIPKN 265 ()
84579 TLITLCHYATSRDP 84620
84620 QQFRDPDSFRPQRWGDRSDRSHPYATVPFGVGKRSCIGRRIAELEVYLALSR 84775
85167 ILMHFTVEPARQDDTVHPMTRTLLVPERQIDLRFTER* 85280
CYP27B1 Fugu rubripes (pufferfish)
No accession number
Scaffold_470
52% to 27B1 human
MLQQALRVSCRSASPLVKWMERWAECASARPQAVKPLGDMPGPSVASFAWDLFAKRGLSRLHELQ (0)
LEGVRRYGPMWKASFGPILTVHVADPALIEQVLRKEGQHPMRSDLSSWKDYRRLRGHHYGLLTS (2)
51430 EGEEWQSIRSLLGKHMLRPKAVEAYDQTLNSVVDDLITKLRLRRSSQGLVTDIASEFYRFGLE 51630 (1)
51726 GVSSVLFESRIGCLDKIVPEETERFIQCINTMFVMTLLTMAMPSWMHQLFPKPWNVFCQCWDYMFDF (1)
AKGHIDQRMAAEAEKIARGEEVEGRYLTYFLSRTSLPMKTVYSNVTELLLAGVDT (0)
52280 ISSTLSWSLYELSRHQAVQASLREEVLSVLGGRRVPTAADVAQMPLLKATIKEVLR 52444 (2)
52527 LYPVIPANARVITERDIQVGGYLIPKN 52610 (0)
52697 TLITLCHYATSRDPAVFPRPDEFLPQRWLNKEQSHHPYASVPFGVGKRSCIGRRIAELELYLAVAR 52894 (0)
53237 ILLEFDIKPDPEGISVKPMTRTLLVPENVINLQFTER* 53347
CYP27B1 Tetraodon nigroviridis (freshwater pufferfish)
93% to CYP27B1 fugu
MLQQALRVSCRSGSPLGKWMERWAECVSARPQGAAAAKALGDMPGPSVASFAWDLFAKRGLSRLHELQ (0)
LEGVRRYGPVWKASFGPILTVHVADPALIEQVLRQEGQHPMRSDLSSWKDYRRLRGHHCGLLTS (2)
EGEEWQSVRSLLGKHMLRPKAVEAYDQTLNSVVEDLIAKLRLRRSSEGLVTDIASEFYRFGLE (1)
GVSSVLFESRIGCLDETVPEETERFIQSINTMFVMTLLTMAMPRWMHQLFPKPWNVFCQCWDYMFDF (1)
AKGHIDQRMAAEAEKVARGEKVEGRYLTYFLSQTDLPMKTVYSNVTELLLAGVDT (0)
ISSTLSWSLYELSRHRAVQASLREEVLSVLGGRRVPTAADVAQMPLLKATVKEVLR (2)
LYPVIPANARVIAERDIQVGGYLIPKN (0)
TLITLCHFATSRDPAVFPQPDRFQPQRWLSREQSHHPYASVPFGVGKRSCIGRRIAELELYLAVAR (0)
ILMEFDIKPDPEGISVKPMTRTLLVPENVINLQFTER*
CYP27C1 human
GenEMBL AC027142
BM562765 BI459427 ESTs
43% identical to 27A1 assembled gene
intron starting with QIH ending in VDT is from Celera's data
CRA_Gene|hCG42613 /len=10487. This Celera sequence is still missing the C-terminal. Probable last exon is now found in AC027142. AG Intron boundary is in the same location as CYP26B1. Stop codon is one codon away from 26B1s stop codon. Length is preserved from cys to intron. (n) = intron phase, 9 exons
1 85452 MQTSAMALLARILRAGLRPAPERGGLLGGGAPRRPQPAGARLPAGARAEDKGAGRPGSPPG 85634 61
62 85635 GGRAEGPRSLAAMPGPRTLANLAEFFCRDGFSRIHEIQ (0) 85748 99
100 39574 QKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGAAPQRANMESWREYRDLRGRATGLISA (2) 39371 163
164 43984 EGEQWLKMRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGETVTNVNDLFFKYSME (1) 43787 229
230 41743 GVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAGAIPRWLRPFIPKPWREFC 41564 290
291 41563 RSWDGLFKFS 41534 300 (1)
301 QIHVDNKLRDIQYQMDRGRRVSGGLLTYLFLSQALTLQEIYANVTEMLLAGVDT (0) 354 (Celera sequence)
355 110201 TSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAADVPKVPLVRALLKETLR (2) 110034 410
411 108566 LFPVLPGNGRVTQEDLVIGGYLIPKG (0) 108489 436
437 108006 TQLALCHYATSYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQ (0) 107794 504
505 102503 LLQHFEIKTSSQTNAVHAKTHGLLTPGGPIHVRFVNRK* 102619 542
CYP27C1 Pan troglodytes (chimp)
XM_525906.3 1 aa diff to human, missing the N-term
MRSVLRQRILKPKDVAIYSGEVNQVIADLIKRIYLLRSQAEDGE TVTNVNDLFFKYSMEGVATILYESRLGCLENSIPQLTVEYIEALELMFSMFKTSMYAG AIPRWLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLRDIQYQMDRGRRVSGGLLTYLF LSQALTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERH VPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVIGGYLIPKGTQLALCHYAT SYQDENFPRAKEFRPERWLRKGDLDRVDNFGSIPFGHGVRSCIGRRIAELEIHLVVIQ LLQHFEIKTSSQTKAVHAKTHGLLTPGGPIHVRFVNRK
The mouse and probably rat have lost 27C1 due to a chromosome rearrangement between BIN1 and ERCC3
It seems that 27C1 was broken and lost in this event.
In fugu CYP27C1 is on the minus strand of scaffold 106 from 31916-36680 the
neigboring gene, 2624 bp away, is ercc3 at 39305-43553 minus strand (also found in human 39kb away)
Therefore, this linkage is very old. The next gene in the series ERCC3, CYP27C1 is BIN1 in human.
In mouse chr 1 is syntenic to human chr 2 at ERCC3, but BIN1 is on chr 18, implying a chromosome break.
CYP27C1 Bos taurus (cow)
See cattle page for details
MALLARILKARPSPAAGRTGLLGGWDAGQPRLASSGLSARARAEDKGAGRPGASQAGGR
AEGPRSLAAMPGPRTLANLVEFFGKDGFSRIHEIQ
297 QKHTREYGKIFKPHFGPQFVVSVADRDLVAQVLRAEGASPQRANMGSWQEYRDLRXRS 476
477 TGLISA 494
EGEQWLKMRSVLRQRILKPKDVAIFAGEINQVIADLIKRIYFLKSQAEDGDTVTNINDLFFKYSME
GVATILYESRLGCLGNSIPQLTADYIEALALMFCTFKTSMYAGAIPRWLRLLIPKPWQEFCRSWDGLFEFS
QIHVDNKLRDIRCQMERGERVRGGLLTYLFLSQELTLEEIYANMTEMLLAGVDT
TSFTLSWAVYLLARHPEVQQALYREIVRNLGERHVPTAADVPKVPLVRALLKETLR
LFPVLPGNGRVTQEDLIVGGYLIPRG
TQLALCHYATSYEDENFPRAKEFRPERWLRQGNLRRVDNFGSIPFGYGARSCIGRRIAELEIHLLVIQ
LLQHFEIKTSPWTKTVHAKTHGLLMPGEPIHVRFVNRK
CYP27C1 Canis familiaris (dog)
XM_540989.2 revised
85% to CYP27C1 human
MALWARILSTRAASAPRRGRPPAPAAQQQPRPQGARPPAGVRTRARA*DKGAVRAL
ASRAGGRDHGSRSLAA
MPGPRTLANLVEFFWKDGFGRIHEIQ
QKHTREYGKIFKSHFGPQFVVSIADRDMVAQVLRAEGATPQRANMESWQEYRHLR
GRSTGLISAEGEQWLKMRRVLRQRILKPRDVAIFSGEINQVIADLIKRIYILKSQAED
GETVTNVNELFFKYSMEGVATILYESRLGCLENSVPQPTVDYIEALGLMFSMFKTSMY
AGAIPRWLRPLIPKPWLEFCRSWDGLFKFSQIHVDNKLKDIQCHMDRGERVRGGLLTC
LFLSQELTLEEIYANMTEMLLAGVDTTSFTLSWAVYLLARHPQVQQTLYQEIVKNLGE
RHIPTAADVPKVPLVRALLKETLRLFPVLPGNGRVTQEDLVVGGYLIPKGTQLALCHY
ATSYEDENFPRAKEFWPERWLRKGSLDRVDNFGSIPFGYGVRSCIGRRIAELEIHLAI
IQLLQHFEIKPSSWTKAVPAKTHGLLTPGGPIHVRFVNRK
CYP27C1 Gallus gallus (chicken)
GenEMBL BU235126 BU209688
Partial seq missing N and C-terminals
78% to Silurana 27C1 82% to human 27C1
PGLSGSQSLEVRSGAENKAARPGELLEPSPQLGRV KSLHEMPGPNTLYNLYEFFWKDGFGRIHE
IQQKHTQEYGKIFKSHFGPQFVVSIADRDMVAQVLRSEGRAPQRANMESWQEYRDLRGR
ATGLISAEGEQWLKMRSVLRQKILKPKDVAVYSGGVNEVITDLIKRIYTLRSQEEDGETV
TNVNNLFFKYSMEGVATILYECRLGCLENNVPQQTVEYIEALELMFSMFKTTMYAGAIPR
WLRPFIPKPWREFCRSWDGLFKFSQIHVDNKLKSIQS
QLDQGEEVNGGLLTYLLVSKELTLEEIYA
NMTEMLLAGVDTTSFTLSWAIYMLAKHPEVQQRVYEEIINKLGKDQAPVNRDVPKLPLIR
AVLKETLR
CYP27C1 chicken
XM_422077
80% to human, complete
MSFLTRVLESERTYFQHALFVSRFHQAPGLSGSQSLEVRSGAEN
KAARPGELLEPSPQLGRVKSLHEMPGPNTLYNLYEFFWKDGFGRIHEIQQKHTQEYGK
IFKSHFGPQFVVSIADRDMVAQVLRSEGRAPQRANMESWQEYRDLRGRATGLISAEGE
QWLKMRSVLRQKILKPKDVAVYSGGVNEVITDLIKRIYTLRSQEEDGETVTNVNNLFF
KYSMEGVATILYECRLGCLENNVPQQTVEYIEALELMFSMFKTTMYAGAIPRWLRPFI
PKPWREFCRSWDGLFKFSQIHVDNKLKSIQSQLDQGEEVNGGLLTYLLVSKELTLEEI
YANMTEMLLAGVDTTSFTLSWAIYMLAKHPEVQQRVYEEIINKLGKDQAPVARDVPKL
PLIRAVLKETLRLYPVLPGNGRVTQKDLVVGGYLIPKGTQLALCHYTTSYSEENFPMA
NEFRPERWLRKDNLDRVDNFGSIPFGYGIRSCIGKRVAELEIHLALIQLLQNFEIKIS
PKTAPVHAKTHGLLTPGGSINVRFSDRK
CYP27C1 Xenopus (Silurana) tropicalis (Western clawed frog)
GenEMBL BQ392731 AL629634 AL595312
NM_001011341.1 CX494774.2
74% to human 27C1 not counting the divergent N-terminal
87% to Xenopus laevis 27C1
MAALGQLLRGSARLEGLARSFHRFPGAQAAGQALEHEQAEGVLGATVKGSPMVKN
LKEMPGPSTMANLVEFFWRDGFGRIQEIQQKHARQYGRIFKSHFGPQFVVSIADKDMVAQ
VLRAERDAPQRANMESWHEYRELRGRSTGLISAEGEKWLNMRSVLRQKILRPRDVAMYSG
GVNEVVEDLVKRIRKLRVQESDGLTVTNVNDLYFKYSMEAIATILYECRLGCLDDQIPQQ
TKEYIEALELMFSMFKTTMYAGAIPKWLRPLIPKPWREF
CRSWDGLFKFSQIHVDDRLRQIESQLEKGEEVQGGVLTHLLLSKELDLEEIYA
NMTEMLLAGVDTTSFTLSWATYLLAKNPGIQEAVYQQIVQNFGKDQVPTAEDVPKMPLVRAVVKETL
RLFPVLPGNGRVTQDDLVVGGYFIPKGTQLALCHYSTSYDAECFPAAEEFRPERWIRSGN
LERKENFGSIPFGYGIRSCIGRRVAELEMHLLLIQLLQ
NLEIKPSPQTTTVLPKTHGLLCPGGKINVRFVDRQ*
CYP27C1 Xenopus tropicalis (Western clawed frog)
scaffold_893:261736-267439 exon 3 missing in a gap and
last half not on this scaffold
N-term adjacent to ERCC3 as in zebrafish and human 27C1
scaffold_4119:30-1794 has second half of gene 100% match
NM_001011341.1 short at N-term (58 aa) CX494774.2 68% to human
from refseq database
70% to 27C1 zebrafish
MAALGQLLRGSARLEGLARSFHRFPGAQAAGQALEHEQAEGVLGATVKGSPMVKNLKE
MPGPSTMANLVEFFWRDGFGRIQEIQQKHARQYGRIFKSHFGPQ
FVVSIADKDMVAQVLRAERDAPQRANMESWHEYRELRGRSTGLISAEGEKWLNMRSVL
RQKILRPRDVAMYSGGVNEVVEDLVKRIRKLRVQESDGLTVTNVNDLYFKYSMEAIAT
ILYECRLGCLDDQIPQQTKEYIEALELMFSMFKTTMYAGAIPKWLRPLIPKPWREFCR
SWDGLFKFSQIHVDDRLRQIESQLEKGEEVQGGVLTHLLLSKELDLEEIYANMTEMLL
AGVDTTSFTLSWATYLLAKNPGIQEAVYQQIVQNFGKDQVPTAEDVPKMPLVRAVVKE
TLRLFPVLPGNGRVTQDDLVVGGYFIPKGTQLALCHYSTSYDAECFPAAEEFRPERWI
RSGNLERKENFGSIPFGYGIRSCIGRRVAELEMHLLLIQLLQNFEIKPSPQTTTVLPK
THGLLCPGGKINVRFVDRQ*
CYP27C1a Xenopus laevis (African clawed frog)
GenEMBL BJ086834 CA982419 BQ385474 BJ069739
87% to X. tropicalis 27C1
lower case does not match SwissProt Q4KLS4
MAVLGHLLKGSARLEGLARGFHQFPKIQAAGQALEQEQAEGEL
GARAKEAPMM KSLKDMPGPSTLANLVEFFWRDGFGRIHEIQQKHTRQYGRIFKSHFGPQF
VVSIADKDLVAQVIRAERDAPQRANMESWHEYRELRGRSTGLISAEGEKWLNMRSVLRQK
ILRPRDVAMYTGGVNEVIGDLVKKIHKLRAQESDGLTVTNVNDLYFKYSMEAIATVLYEC
RLGCLDDIIPQQTKEYIAALELMFSMFKTTMYAGglpkwlrhhnfpnpwkef
53aa gap see Tropicalis seq and X. laevis SwissProt Q4KLS4
HMTEMLLAGVDTTSFTLSWATYLLAKNPSIQESVYQQIVQNLGKDQVPTAEDVTKIPMVR
AVVKETLRLFPVLPGNGRVTQDDLVLDGYLIPKGTQLALCHYSTSYDDKCFPGAEEFKPE
RWIRSGYLERKENFGSIPFGNGIRSCIGRRVAELEIHLLLIQL
LQNFEIKLSPETMTVLPKTHGLLCPGEKINVRFLDRQ*
CYP27C1a Xenopus laevis (African clawed frog)
SwissProt Q4KLS4 (missing the N-term)
MPGPSTLANLVEFFWRDGFGRIHEIQQKHTRQYGRIFKSHFGPQFVVSIADKDLVAQVI
RAERDAPQRANMESWHEYRELRGRSTGLISAEGEKWLNMRSVLRQKILRPRDVAMYTGG
VNEVIGDLVKKIHKLRAQESDGLTVTNVNDLYFKYSMEAIATVLYECRLGCLDDIIPQQ
TKEYIAALELMFSMFKTTMYAGaipkwlrtiipkpwrefCRSWDGLFKFSQLHVDHRLR
QIESQLDKGEQVQGGVLTHLLLSKELDLEEIYANMTEMLLAGVDTTSFTLSWATYLLAK
NPSIQESVYQQIVQNLGKDQVPTAEDVTKIPMVRAVVKETLRLFPVLPGNGRVTQDDLV
LDGYLIPKGTQLALCHYSTSYDDKCFPGAEEFKPERWIRSGYLERKENFGSIPFGNGIR
SCIGRRVAELEIHLLLIQLLQNFEIKLSPETMTVLPKTHGLLCPGEKINVRFLDRQ
CYP27C1a Xenopus laevis (African clawed frog)
AW637606 bl60c07.w1, BE669236 dc59c04.y1
N-term 75% to 27C1 human
AVLGHLLKGSARLEGLARGFHQFPKIQAAGQALEQEQ
AEGELGARAKEAPMMKSLKDMPGPSTLANLVEFFWRDGFGRIHEIQ
QKHTRQYGRIFKSHFGPQFVVSIADKDLVAQVIRAERDAPQRANME
SWHEYRELRGRSTGLISAEGEKWLNMRSVLRQKILRPRDV
AMYTGGVNEVIGDLVKKIHKLRAQESDGLTVTNVNDLY
CYP27C1b Xenopus laevis (African clawed frog)
SwissProt Q66IQ5
92% to CYP27C1a Q4KLS4 (presumed ohnolog)
MVKSLNDMPGPSTLANLVEFFWRDGFGRIQDIQQKHTRQYGRIFKSHFGPQFVVSIADK
DLVAQVLRAERDAPQRANMESWHEYRELRGRSTGLISAEGEKWLNMRSVLRQKILRPRD
VAMYSGGVNEVIDDLVNRIRKLRAQESDGLTVTNVNDLYFKYSMEAIATILYECRLGCL
DDKIPQMTKEYIEALELMFSMFKTTMYAGAIPKWLRPIIPKPWREFCRSWDGLFKFSQI
HVENRLQQIESQLNKGEEVQGGVLTHLLLTKELDLEEIYANMTEMLLAGVDTTSFTLSW
ATYLLAKNPSIQESVYQQIVQNLEKDQVPTAEDVPKIPLVRAVVKETLRLFPVLPGNGR
VTQDDLVLDGYLIPKGTQLALCHYSTSFDDKCFPAAEEFKPERWIRSGNLERKENFGSI
PFGYGIRSCIGRRIAELELHLLLIQLLQNFEIKVSPKTTTVLPKTHGLLCPGEKINVRF
VDRH
CYP27C1 Danio rerio (zebrafish)
ctg14633 zebrafish 70% TO FUGU CYP27C1
chr6:7837526-7850296
MARKNLLQESCRQLLIQTHGLHKSVASGSLEIAAHSQADLKEESAVSPAEEVQ
KAARVKSLKEMPGPSTVANLLEFFYRDGFSRIHEIQ 46230
MEHAKKYGKIFKSRFGPQFVVSIADRDMVAQV 48886
48887 LRSESATPQRGNMESWKEYRDLRGRSTGLISA 48982
EGDEWLKMRSVLRQLIMRPRDVAVFSSDVT 50683
50683 DVVADLVKRVKTLRSQQDDSQTVLNINDLFFKYAME 50790
GVATILYETRLGCLENEIPKMSQEYITALHLMFSSFKTTMYAGAIPKW 52654
52655 LRPIIPKPWEEFCSSWDGLFKFS 52723
52813 IHVDKRLSEIKKQMEKSEEIKGGLLTHMLVTREMNLEEIYANMTEMLLAGVDT 52971
55090 TSFTLSWSTYLLARHPTIQQQIFEEVDRVLGGRVPTGEDVPYLPLIRGLVKETLR 55254 ()
LFPVLPGNGRVTHDDLIVGGYLIPKG 55452 ()
58126 TQLALCHYSTSMDEENFPRPEEFRPDRWIRKDASDRVDNFGSIPFGYGIRSCVGRRIAEL 58305
58306 EMHLALTQ (0)
LLQNFHIEVSPQTTEVHAKTHGLLCPGASINLRFTDRK* 58539
CYP27C1 Fugu rubripes (pufferfish)
chrUn:4630123-4635029 UCSC browser
Scaffold_1410
75% to 27C1 human
adjacent to ERCC3
MSVMNKLTTTCWTNFYGDRRNKQMLFVLRCLHKSATSGTFGVAREEPLPERLITSTDATKKRLPKT
19233 LAEMPGPGTISNLFEFFWRDGFSRIHEIQ 19319 (0)
20076 IEHSKMYGKIFKSRFGPQLVVSVADRDLVAEVLRAE
GVAPQRANMESWHEYRDMRRRSTGLISA 20261 (2)
EGEDWLRMRSVLRQLIMRPRDVAVFSDDVSEVVDEVVDDLIKR
IVCLRSQSSDGTTICNINDLFFKYAME (1)
20741 GIAAILYECRLGCLSQKIPQETEDYIDALHLMFSSFKTTMYAGAIPKWLRPV 20911
20912 FPKPWEEFCDSWDGLFRF 20968 (1)
SVHVDKRLKQIESQLQRGEKVTGGLLTYMLVAKEMSVEEIYANVTEMLLAGvdt (0)
23004 TSFTLSWASYLLARHPDVQQQIHAEVMRVLGSEKVATAEDVQHLPFIRGLVKETLR 23183 (2)
LFPVLPGNGRITQDDMVLGGYFIPKG
23623 TQLALCHYSTSLDDENFPSSLEFRPDRWIRKHSSDRLDNFGSIPFGYGIRSCIGKRI 23793
23794 AELEMHLALIR (0)
23998 IIQKFHVCVSPLTTDVKAKTHGLLCPGAPINLQFIDREI* 24117
CYP27C1 Tetraodon nigroviridis
chrUn_random:116718046-116719086 UCSC browser
N-term exons 1 and 2 only, adjacent to ERCC3
63% to Fugu CYP27C1
rest of gene in a sequence gap
MSVMNKLTTVCWRNFQSDCHHRQMRFALRCLHKSATSGAFGAAREEAVPERLITPKDAAQKK
SGKSLAEMPGPGTVSNLIEFFWRDGFSRIHEIQ (0)
MEHSKMYGKIFKSRFGPQLVVSVADRDLVAEVLRAEGVAPQRGNME
SWHEYRDLRGRSTGLISA (2)
CYP27C1 mouse and rat
Mouse is missing this sequence in blast searches. In humans it lies between
BIN1 and ERCC3 on chr 2. This region does not contain 27C1 in mouse (chr 18)
unless there is a sequence gap. Blast of the rat genome
(Rat Genome Sequencing Consortium Assembly Posted date: Dec 4, 2002)
also had no hits, so 27C1 may have been lost in rodent evolution.
It is present in human, Fugu, Xenopus, Silurana (another frog) and chicken.
The absence of 27C1 may be a useful synapomorphy for comparing rodents to other mammals.
CYP27D1 Petromyzon marinus (Lamprey)
Contig17808:3625-10857 (-) strand
missing N-term exon in a sequence gap
This sequence is more like CYP27A3 or CYP27B1
47% to CYP27A3 Fugu
IIHHKRFGSMWTSYTGREMFVCLADPDLIEQLMRQEGPYPVRVIMSAWDDYLMMRGHSKGLLTQ (2)
TGADWKRMREVLNQRMLKPREVMQFADPLNAVVTELMGHVRARRGNGAATAVFPLPDVAQLLYRFAFE ()
GVTTVLFETRMGSLEETVPKETQDFIRAIESMLSTTVHVMALPRWTRPLLPFWGRFVQGWD
GSITAATRLINVKLAEVKDCISRGQEVRGEYLTYLLASDRLSLPEIYSNTTDILLAGVDT ()
TSNTLSWSLYHLAQMPALQEALCREVNAVVPGDAVPGIDEVARMPLLKAVIKETLR ()
LYPVVFQNARCIVDDGVVLGGYSLPKG (0)
TNLSLCQYVLSMDGDVFPNPREFQPQRWLRGKDRAAWRHGSGGEGEEGAAAADDAATSEK
THPFAYIPFGFGLRGCVGRRIAELEMHLCLAR (0)
FVKTFEMMPEPGAKKVLPKTRGVLVPSTPINLLLRERL
Traces from next contig upstream
All of these are in a long repeat sequence
Cannot find a mate pair seq that is outside of the repeat.
1193719280, 1255501914, 1472630360, 1470299497, 1467953899, 1466704577,
1443851513, 1447257494, 1196739470, 1266761373, 1466575034
1466508070, 1266008803, 1193867804, 1443531934, 1468578376
Similar gene exon 2, trace 1467681227 Petromyzon
DLNIRRNSYDHLEQLKLQCGGILTSYTGREMFVCLADPYLIEQLMRQEGPYPVRVI
MSAWHDYLMMRGHSKGLLTH
(mate = 1468976488 exon 5)
TSNTLS*SLYH
AQMPALQEAWCREVNAVV
PGDAAPGIDEVARMTLLKAVIKETLR
Vertebrates
CYP27E1 Branchiostoma floridae (Amphioxus)
40% to 27B1 Fugu, 37% to 27C1 fugu,
40% to 27A1 fugu (but not first exon)
35% to 11A1 fugu, 34% to CYP24 fugu (Best match to CYP27B)
MAQQILRNSSVCSLVRPNSRALVSVAPAATVQQNRPLKEMPGPTNKLGQLWWGFKNRSRMHEAQ (0)
LEQERKYGRMWQSSFGFNPNVNVAHVALAEQLMRQEGKYPKRIEVNFMQQYRDLRGYSYGLLNQ (2)
NGPEWRHLRTAVSKRIMRPKEVPR (2)
YGDSMNEVVTDMIDRFKDLRDTTGGGKTVPDLTNELYKWAME (1)
SIATVLFDTRLGCLEREMPEKTQQFIDSIATMFRTAFLVSALKPWMLTYLGLGVWKRHVEAWDVIFSV(1)
AHENIDRKVLDIDARLSRGEDLVGSFLTYMLTGTDVTKKDLYATVTELLLAGVDT (0)
TSNTMVWTLYELARHPELQERLHQEVTSVVSPGQIPTVDDVKNMALLKNVIKEILR (2)
VYPVLPANGRVLDKDIVLDGYNIPKG (0)
TQFAILHYNMTRDPEVFEEPDRFNPDRWTRMGTEKVNTFSSVPFGFGPRQCA (1)
GRRLAEMEMYLVLAR (0)
LVQTFEVRQLTPGEVVRPVTRALLVPGDPVHLEFIDRP*
CYP27F1 Strongylocentrotus purpuratus
XP_790546.2 CX682858.1 EST
CYP27B like 40% to 27A in Xenopus
Missing C-terminal
1 MATRLSRFLA RARPSRSSGV RPQTFHDAHA SSCPLAAVPS TLSPHASTTT PSTPSTTKTS
61 TTSTTSAPSS ISDLPSNNNL SLGVSNGCTF DQAPTSINPS ERNCTIFDDV KSFKDIPGPK
121 GWPILGTLGT YLSGKGLERI YDHQIDFTKK YGPIWKERLG TLEFVNLAKP DLVEVMYRND
181 SRYPRRLDMK PWKVYRAHRD ESLGVLTHEG KEWHRARRTI GRKIMPPREV AKFTGVINEI
241 VTDMVERLRF VRDTKGEGDG VVPELQNEMY KWSKGSIFKL LLETRIGCXK EPIPEKSQGF
301 INAVGQMFAS GQIMFLTSPE WFRRWNLKPW RDHEAAWDYI FNFAKKSVDA RLQELATLAE
361 EGDVVEDSGI LTHLLASQQL SMKEVYSNAC ELLLAGVDTT SNTLAWALYE LSRHPDTQDR
421 LAKEVEGALA AKGRCIPEHD DLPNMPLLKG VIKETLR
LYPVVPANNRVLDKDVTIGGYHIPKG
28A Subfamily
CYP28A1 Drosophila mettleri
GenEMBL U89746 (1895bp)
Danielson,P.B., MacIntyre,R.J. and Fogleman,J.C.
Molecular cloning of a family of xenobiotic-inducible drosophilid
cytochrome p450s: evidence for involvement in host-plant
allelochemical resistance.
Proc. Natl. Acad. Sci. U.S.A. 94, 10797-10802 (1997)
note: 369mt, full length, one of 109 seqs submitted to Nomenclature
committee
CYP28A2 Drosophila mettleri
GenEMBL U89747 (1764bp)
Danielson,P.B., MacIntyre,R.J. and Fogleman,J.C.
Molecular cloning of a family of xenobiotic-inducible drosophilid
cytochrome p450s: evidence for involvement in host-plant
allelochemical resistance.
Proc. Natl. Acad. Sci. U.S.A. 94, 10797-10802 (1997)
note: 43mt, full length, one of 109 seqs submitted to Nomenclature
committee
CYP28A3 Drosophila nigrospiracula (a desert dwelling Drosophilid)
GenEMBL U91565 (451bp)
Danielson,P.B., MacIntyre,R.J. and Fogleman,J.C.
Molecular cloning of a family of xenobiotic-inducible drosophilid
cytochrome p450s: evidence for involvement in host-plant
allelochemical resistance.
Proc. Natl. Acad. Sci. U.S.A. 94, 10797-10802 (1997)
54 amino acids
CYP28A4 Drosophila hydei (a desert dwelling Drosophilid)
GenEMBL U91566 (366bp)
Danielson,P.B., MacIntyre,R.J. and Fogleman,J.C.
Molecular cloning of a family of xenobiotic-inducible drosophilid
cytochrome p450s: evidence for involvement in host-plant
allelochemical resistance.
Proc. Natl. Acad. Sci. U.S.A. 94, 10797-10802 (1997)
54 amino acids
Cyp28a5 Drosophila melanogaster
GenEMBL AC018242 6065-8082 also AC001660
Cyp28a5 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP28B1 Musca domestica (housefly)
no accession number
Nannan Liu
44% identical to 28A1 over 498 amino acids
submitted to nomenclature committee 7/29/99
Cyp28c1 Drosophila melanogaster
GenEMBL AC014191 comp(8254-10002) also AL133495
Cyp28c1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp28d1 Drosophila melanogaster
GenEMBL AC017780 comp(28385-30262) also AC009355 AC008324 AC008327
Cyp28d1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp28d2 Drosophila melanogaster
GenEMBL AC017780 comp(31545-33456) AC008324
CYP28E1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee March 17, 2005
Clone name Lc_CYP28D
48% to 28D1 (148 aa)
CYP28F1 Bactrocera orientalis (oriental fruit fly)
No accession number
Yong Huang
Submitted to nomenclature committee March 16, 2012
49% to Cyp28d1 Drosophila melanogaster
29A Subfamily
CYP29A1 Caenorhabditis elegans (nematode worm)
GenEMBL Z69787 and AL022276 (Y102F5)
C44C10.2 (with modifications)
note: GeneFinder translation is incorrect in some regions.
First exon probably ends at 11181 coding for 35 amino acids as does
the first exon
of CYP29A2.
There is probably a sequence error in the stop codon at 11155-11157.
2nd exon probably runs from 11227-11293.
11400-11518 is the third exon.
12465 to 12979 should be one exon.
There is probably a sequence error in the stop codon at 12879-12881.
some segments around I-helix missed by genefinder. N-terminal of
genefinder translation is probably a different gene. Matches
F23A7.3, but this gene
does not have a P450 sequence downstream.
CYP29A2 C. elegans
GenEMBL Z74043
T19B10.1
nearly the whole gene of wEST00713, CEMSH91R, missing 5' end
CYP29A2 C. elegans
GenEMBL Z74040
T19B10.1
5' end of gene from Z74043
CYP29A2 Caenorhabditis briggsae ortholog
XP_002636467.1 V - 7235792-7237902
MTIIIPIIFGMVLIYLSTWIPTLRKFRRHWRYGNK
MPGPPAHPIYGNLGPIVGLNTE
DLPAVFINWAAEQRDKGNSIMRVMLLGTVYVWPLNGKAAAAIVDSTTETNKGDDYEFFSP
WLGGGLLLEGYGERWRSHRKMLTPAFHFAKLGGYFEVFNNEAK
IMVDLLSDFCDSGKTVDIFPYVKRCALDI
ISETAMGIKIDAQMNHDHKYVQAVEGFNKIGVLVSFNPHLKNPFIFWATGYKAQYDDYLH TLKNFTEKVIKERRAAHESGEIEVEKSKRMMNFLDLMLSMEEANQLTSEDIRQEVDTFMF AGHDTTTSSTSWACWNMAHHPDVQEKVYKEMMEVFGDDPSTDITLENLGKLSYLDRVLKE SKRIIPPVPALQRKLTNDLEI
SDGYTVPAGGNVTISPMVLHSNHLV FDNPEKFDPDRFLPDEVSKRHPYDFMPFLAGPRNCIGQKFAQLNEKVMLCHIIRNFKIEP TLGYKDTKQCLEVVTKPSKGIPVRLVRKI*
CYP29A3 C. elegans
no accession number
Y108G3 contig 541
CYP29A4 C. elegans
GenEMBL Z99102
B0331.1
CYP29A4 Caenorhabditis briggsae ortholog
XP_002637596.1 V + 11212878-11215991
MSILIPVAVLLFLVYILSFYDHVRLMRKFWIYGGK
MPGPPAHPIFGNASLFKNKTTE
DFVEIFVNLANEARAKGANLMRTQVMNRIYVWPLNGKTAA
FILESSTEMNKGDDYSFLVPWLGGGLLMAQGEKWKNHRKMLTPAFHFAKLEGYLDVFNQESK
VLIDCIEKAMETQEMIDLFPFFKRCTLDIICGTAMGIKFGAQLGKNHEYVKAVEGFNKLT
VEYSLNPFLWNKFVYWALGYQKMHDDFLLTLKKFTNDAIVERRAAIASGEVEKETS KRKMNFLDILLSSEESNELTSEDIRKEVDTFLFAGHDTTSTSLSWLCWNLAHNPDVQENV YREILTVFGEDPNEDVTSEKINRMEYTERVMKESKRMFAPVPGVQRKLTKDIVI DGITIPSEGNITISPTVLHCNPYIYEKPEKFDPDRFLPEECAKRHSYDYIPFSAGLRNCI GQKFSILNEKVMLIHILKHFRLEPKLGFYETKPLFE
VVAKPSHGIPMKLIRRY*
CYP29A5 Caenorhabditis briggsae
XP_002637200.1 V - 7589851-7591489
MALLIPILLGVLAIIFVMCSKRIKWILKVFEFSDKLPGPTTQPFIGNISSFAKMSKI
EMLDYMIKTANELRDSGESIMRFQFIGKLLVFPLDGKSAQTLLQSTTELDKGDDYEFARAWLGRSV
LLDGYGERWKSHRRLVTPTFHFAKLEGYLGVFNRETK
VMVELLDEF
AKSGETVDLFHYIKRCTLDIICGTAMGTTIDAQHNPTHSYVLAVERFNKLS VDHSMKAHLQIPFLFWLLGYQKKKDDYVYTMKKFTRDVTAGRMTGL
KLGHIENHASKRDMNFLDILLCSKETKDWSE
EDIREEVDTFMFAGHDTTAASFSWMCWNMAHNQDIQEKVYKEIIEIFGDDPNGDVDSEGI
KKLDYTERVLKESKRRIAPVPTLQRKLREDMEI
GGHMIPAGVNISVA
RNAYDYIPFSAGLRNCVGQKFAQLNEKVLLIHMLRNYRIEPMLDFNGTQPSLE
IISRPSNGIPVMLTRR*
CYP29A6 Caenorhabditis briggsae
XP_002637594.1 V + 11205486-11207316
MALIVPVFIALVVIYILSFYKQIRNYFRLNHYGSKLPGPPLERIMGNANILKNKTSD
KMGLVFKEEARKARERGDSIVRYLLPGKLIVWPLNGKAVSQVLDSTT
EIHKGSDYEMFKPWIGGLLLLL
VGDTWKFHRKLITPTFHFAKLEGYFNVFNSESK
ILTELLEKFADSGETVDIFPYINRCLLDIICEAGMGTKVDAQFNHDHPYLKAVKGYVELM
MKTSTRPLLWNPFLFWALGYKRQQMDYLKTLKKFTAD
VIAERKQARELEGQTGASVSKRNMNFLDLMLSTKESNGLTEEELRNEVDTFMFGGHDTT
TTSCSWMVWSLAHHQDIQQKVHEEIVSNCGEYPNEEITYEQANKLYYLELVMKESKRFFP
PVAAVQRHLQEPMVI
DGHKIPAGTNIAIAPLVLHSNPEVFKNPEVFDPNRFLPEECAKRHAYDYIPFSAGVKNCI
GQKFSVLNEKVLISHLVRNFKIEPMLELDGTRPCFEVVSRPSKGIPVKLTRRL*
CYP29A7 Caenorhabditis briggsae
XP_002637595.1 V + 11208539-11210751
MALLVPVFVSFLVLILFWLFQKYQKIQKVNYYGSQIPGPKGNWLTGNLSMFQKSNT
GLIEMFQEEAKKFREQGHSVMRYIMPGKLLVFPLTGKTVSKILESTTEI
EKGEDYDFFEPWIGGGLLVS
VGERWKSHRKLITPSFHFAKLEGYF
DVFNQESK
ILVECLEKFSDSGEQVDLHPFINRCTLDIICETAMGTKVGAQFNHDNSYLKAVDGYSTMMV
1756313 KYAYNPIMWNPFLFWILGHKKRQNDLLYSLKKFTGD
IIAERKAALESGEAEKFTSKRSMNFLDLMLSMKESNVLSEEDLRQEVDTFMFGGHDTTTT
SCSWTCWNLAHNPEVQQKVCEELAEVCGEDPNGDISYEQANQLHYLDRVLKESKRLIAPV
ALVDRKLQKEMEI
SGYIIPPGSSVSIAPVILHNNHDVWKNPEVFDPDRFLPEECAKRHPYDFVPFSAGIKNCIG
QKFSVLNEKVMVSHLVRNFKIEPMAKFHETLPCFESVSKPSNGIPVKLIRRV*
CYP29A8 Caenorhabditis briggsae
XP_002638306.1, XP_002638307.1 V + 14216296-14221511
MTLIYLFIFSIFLFFVSFFWKTIKRILRFRKFDNK
IPGPPTSPILGNVQTFRNKST
SELNQIFLDAAEKCRNSKSNYMKYRILDKLFVLPLNGKSAA
KILESSSELNKGDDYDFFEPWLGGGILVGRGEEKWRTHRKLLTPSFHFAKLEGYLEVFNTESR
ILVSCLDELSDSSNPIDIFPYIKRCALDIICAAVMGTKVDAQLYHNHPYVNAVEMFSVLV
IENAINPIFQIPPLFWLLGYQKQKEECIKVMKEFSTSVISERKAALDSGEIE
KETKKRKMNFLDILLKESS
LSPEDVRQEVDTFMFAGHDTTTSSVS*ACWNLAENPEIQDKVYKELVKVFGGDEDVTY
EKMSELEYTERVLKESKRLVAPVPMVQRKIISDMEI
DGITIPSGANISISPMLIHKNPEVFPNPAIFDPDRFLP
DEISKRNAFDYIPFSAGLRNCVGQKFAQINEKVMIAHILRNFRLEPCGVTKPALEPIARPSNGIPVKLIRR
CYP29A9 Caenorhabditis briggsae
XP_002645410.1 possible ortholog to CYP29A1
MAFLIPALVALLLVIIATLWKKISNLQKFRKCDDT
IPGPPAHPIFGNVSAFSGKNTA EIYEIFRKTADEFRSKGKNVIRYRFLDKLYVWPLTGKALA
KVLESTTELNKGDDYKFYYSWFGGGVLVEGFGERWRTHRKLLTPTFHFAKLEGYLEVFNEESK
IMIECLDKYAESGKTVDMFEYIKRCALDVICGAAMGTKVNAQYYHEHPYVKAVEGFNTLA
IQHALNPLYEFDFIYWALGLKKQKDEYLHTMKKFTGDVIAERQAAIASGEV
EKETSKRKMNFLDILLSSGEANILSDEDIRQEVDTFMFAGHDTTTTALSWMCWNMAHHPD
IQQKVYEELVSIFGEDPHTEVTTEGLSKLDYTERVLKESKRQTIPVPALQRKLINDMEI
DGYTIPSGANVAIAPMVLHKNAEAFPDPDKFDPDRFLPDEIAKRYAYDYIP
FSAGLRNCIGQKFAQMNEKVMLIYILKNFRLEPMAGFNSTKPVFE
QAVARPSHGIPVKLIRRN*
30A Subfamily
CYP30A1 Mercenaria mercenaria (northern quahog, a clam)
GenEMBL AF014795 (1628bp)
Brown, D., Clark,G.C. and Van Beneden,R.J.
A novel cytochrome P450 from the clam, Mercenaria mercenaria
Unpublished
CYP30B1 Mytilus edulis (blue mussel)
AB479539
38% to CYP30A1
31A Subfamily
CYP31A1P C. elegans
GenEMBL Z68213
C01F6.3
missing 25 amino acids at C-helix plus in frame stop codon at ERK*
CYP31A2 C. elegans
GenEMBL Z68336 and Z92789
F22B3 and H02I12
This gene is definitely different than CYP31A3, there are 8 amino
acids differences
and the introns are divergent.
CYP31A3 C. elegans
no accession number
T16C6 this sequence revised according to Y17G9.contig 61
cosmid T16C6 lies 3' of E04A4 and 5' of R11E3. Y17G9 contig 61 covers
this
region. E04A4 ends at 29981 of Y17G9 contig 61 R11E3 starts at 49037
of Y17G9
contig 61 this sequence lies between 41545-45037
CYP31A4P C. elegans
no accession number
Pseudogene related to CYP31A sequences 44849-45028 of Y17G9.contig61
C-TERMINAL exon fragment, This sequence is inside the last intron of
CYP31A3
CYP31A5P C. elegans
CYP31A6 Caenorhabditis briggsae
XP_002634204.1 84% to CYP31A2 83% to CYP31A3
MGVIIPVVLVAFATVFMWLLFKHLRMRHKLKHINQPRSYPIVGHGLITKPDPEGFMNQVIGMGYLYPDPR
MCLLWIGPFPCLMLYSAELVETILASSKHLDKGFAYKQLEPWLGRSILTSRKDQWRPKRKLLTPTFHYDI
LKDFLPIFNEQSKIMVQKMCYMGKDENIDVLSTVTLCTLDIICETSMGKSIGAQLSENNEYVWAVHTINE
LISRRTNNPLLWNSHIYSLTEDGKTHEKCLNILHSFTKKVIIERKEALKESGYKMEGRLAFLDLLLDMVQ
SGQMDETDVQAEVDTFMFEGHDTTSTGLMWAIHLIGNHPEIQRKVQAELDEVLGDEEDVTTEHLARLKYL
ECVLKESLRIRSSVPIIMRELSEDQVIGGINIPKGVTLLLNLYLVHRDPAQWKDPEVFDPDRFLPENSVG
RKPFAFIPFSAGSRNCIGQRFALIEEKVIMTHILRHFDVTSIEPMHEVRPKMEIIMRPVSPVHIKITRRR
PIVSP
CYP31B1 Uncultured nematode from host Ips paraconfusus
(California fivespined ips, bark beetle)
DQ471885
Dezene Huber
Submitted to nomenclature committee May 19, 2005
54% to CYP31A2 C. elegans over 456aa
missing 5' end (no signal peptide)
nematode contamination, not an insect-like sequence
32A Subfamily
CYP32A1 C. elegans
GenEMBL U53148
C26F1.2
CYP32A1 Caenorhabditis briggsae ortholog
XP_002635600.1 87% to CYP32A1
MIIVFAIIIGYAIYLFVVNFPQILELWRVNRKCAQNLSMVMGPPSLPLVGSAHLFKWHPYDFTFQMEQWA
QKYLFSRAKYGEIAAPNNEVDGIMLLWIGPVPIVFLGMSECIRVVLESNTNISKPSQYDKMSEWIGTGLL
TSTHEKWFHRRKMLTPTFHFSIIQDYFPIFARHAEVLVEAVEPHVDGDFFDGFPYFKRCTLDIICETAMG
IQVNAQLGQNNEYVHAVKRISEITWNHMKFPWLWLKPIWYLTGLGFEFDRNVKLTNDFVRKITYRKWLLE
SSLISVPVQDIKKLISRIIFQVIHDRKELLKEENEENSRKRKAFLDLLLTIQKEKGTLSDEDIREEVDTF
MFEGHDTTSSGIGFTILWLGFNPEFFGFASDQTPTMDDIKKCSYLEKCIKESLRMFPSVPLIARRLSEDV
TIDHPSGQKIVLPAGLAACVSPIAAARDPRAYPDPDRFNPNNFDIDAIAGRDPYAYIPFSAGPRNCIGQK
FAILEEKTVLSTFFRKFEVESLQTEENLRPIPELILRPYNGIRIKIKRREADFVVY
CYP32B1 C. elegans
CYP32B1 Caenorhabditis briggsae ortholog
XP_002636022.1 79% to CYP32B1
MIAAILVALLTYFLFSIFQKRHEIQKFLYARRICIQEFEKVKGPPAVPIFGTTWYFKSDPIE
MIKQAQKWFVEYTLAPDSNGLLKRKAFQFWMGPVPVVSICRGEVAKTIFDSSTNIPKSSQYRKLKEWIGD
GLLISTGPKWRSRRKMLTQTFHFAVLKEYHKVFASQGKILVDVLRLRANNTYPFDIMPYIKRCTLDIICE
TAMGCSISSQMGSNDKYVESVKRLSELVWNYEKAPLYWLKPIWYLFGNGFEFDRLVKLTTDFTRDVIDKR
KEELKLHESEPSDKKLAFLDYLLKSQTDHPEILTDEGIREEVDTFMFEGHDTTSSGIKFAIWFLGQYPEY
QQQVQDEMDEIFGDDYERYPNSEDIQRMIYLEQCIKETLRLTPPVPFISRQLEEDVLIPHATKPPVLLPA
GMNIMINIITIMKDARYFEKPYEFFPEHFEPERVNSREAFAYVPFSAGPRNCIGQKFALLEEKVVLSWIF
RNFTVTSMSKYPEEHPIPELILKPQFGTQVLLKNRRKF
33A Subfamily
CYP33A1 C. elegans
GenEMBL U55365
C12D5.7
CYP33A1 Caenorhabditis briggsae ortholog
XP_002648880.1 74% to CYP33A1
MIVLLIFTFTVLYFFNEFYWKRRSLPA
GPTPLPIIGNMLE
MFSYPPPGTSAFSAWTQKFGKIYTIWMGTTPAVVVTGYKELKETFVNDGDSYSDKMIVNKFNTSFRGGDF
GVIDTNGNTWKEHRKFALHTLKDFGMGKEAMEASIQLEVDNIEKELKRMEGKDVNLQELYDMAIANVINQ
FLFGIRFNNPAKFNEIKSYLDDFFDVQGSMRVYLSYTINWLPQWMVELLTPDVAKTREGIFGFLEQQIKE
HREEIDFDSEDSKDFVEIFMKEQKRRESEKDHETFSNDHLRNMCFDMWSAGMHTTSNTMGWLTAFAMNNP
DAQRKMQKELTEVVGDRMVTMKDKLKLPYTNAFINETQRLANLVPINLPHATTRDVELAGCIVPKGTTVI
HQISSVLYDPEIFPEPRKFKPERFLDDSGNLKKSEELIPFSIGKRVCLGEGLARMELFLFTANLFNQFEF
LESANGVPSLERTYSAVAKVMDFKCRVQARYSS
33B Subfamily
CYP33B1 C. elegans
GenEMBL U50311
C25E10.2
CYP33B1 Caenorhabditis briggsae ortholog
XP_002637457.1 V + 10551777-10554400
MIPLILLLCFVFFLLHQYLWRRRGLPPGPTPIPVFGNLFQLSGSEAPGISIFQKWKDQYGPIFTFYM
GPVPFVVLTDYQDIKETIIKDGETYADKYLSPEFNLYFR
GGEYGIMDISGDRWREHRKFAVLQLRELGVGKSQMESKILEEAEELVKKLKTCEVLQEDFVLQTDLDVAVGSV
INQFLFGYRFDESKMHEFVKIKTLVNNFMEEVGKPLGVLAFTCHGIPPFIVKQMVSGIEEQKRELFGFLR
AQIQDAKLRINYEEEHNDDFVEAYLRKKYQREQNNDFESYCDSQLENVCFDIWAAGFDTLTNTIGFLFAY
AINYPEMQKIIHQEIDEYLGHHRRLLTMSDKNSLVYFNAFANETQRLANILPMNLPHALTRDVELKGYHL
KKGTGVIHQIANVMTDET
IFPNPYRFDPTRFIDENGKLRKVEELCPFSMGKRQCLGEGLARMEIFLLAANLFNYFE
FLPASDGLPSLFKDFSLVSHVIPFMCRIRSRDHPEESK
33C Subfamily
CYP33C1 Caenorhabditis elegans (nematode worm)
GenEMBL AF039053
C45H4.a near 35k
CYP33C2 Caenorhabditis elegans (nematode worm)
GenEMBL AF039053
C45H4.b near 38k
also on Y10C10 contig 60. Probable end of 33C2 gene is on contig 57,
but the intron ends of these two contigs do not overlap yet.
CYP33C3 Caenorhabditis elegans (nematode worm)
GenEMBL AF016676
F41B5.b 5k to 7k
CYP33C3 Caenorhabditis elegans (nematode worm)
GenEMBL D35162
EST 5 prime read with heme signature
3 prime fragment of this clone yk18a10 = D32508 (not in coding region)
this is a portion of clone YK824
CYP33C4 Caenorhabditis elegans (nematode worm)
GenEMBL AF016438
F44C8 whole gene of EST CEL10E1
CYP33C4 Caenorhabditis elegans
GenEMBL M88882 (501bp)
EST CEL10E1
2nd frame contains PPGP and KKYG from N-terminal region of
many P450s.
CYP33C5 Caenorhabditis elegans (nematode worm)
GenEMBL AF016676
F41B5.c
CYP33C6 Caenorhabditis elegans (nematode worm)
GenEMBL AF016676
F41B5.e
CYP33C7 Caenorhabditis elegans (nematode worm)
GenEMBL AF016676
F41B5.d
CYP33C8 Caenorhabditis elegans (nematode worm)
GenEMBL AF003385
R08F11
CYP33C9 Caenorhabditis elegans (nematode worm)
GenEMBL AF016449
C50H11
CYP33C9 Caenorhabditis briggsae ortholog
XP_002636010.1 XP_002635453.1 V - 1644227-1646905
MVLNLILVAAVAFLFHQLIWKRRNWPAGPTPLPLIGNLLSLRSPAPGYQAFDKWTKKYGDIYTFWLGTRP
YILVSSYEALKETFIKDGETYADKKPMAFQEAFRGGSYGVVETNGPFWREHRRFAIHQFRDFGVGKDRME
QRIMIEVEDIFRNCDKTLGEGVDLTDIFDRAIGNVINQMLFGYRFDETRADEFRTIRAFFNFNSGEFASF
SMRVQFFLPWMGYIMPGPTILDRFKKYQKGFTEFFGTQIANHKNEIDFELEDNSDYVEAYLKEQRKREKE
GDFESFSTKQLSNMVLDLWFAALMTTSNTMTWCFAYTLNYPDAQKKLHEELDRIIGSDRQITTADKPNLP
YTNAYINEIQRTANLVPLNLLHMTTKDTVLKGYHIPKGTGVVAQISTVMYDEEVFPEPYIFNPDRFIDEE
GKLKKVEQLVPFSVGKRQCLGEGLAKMELFLFVANFFNRYETVPDSSGAPEIDKAKLGGMHTKEFRAILK
KRHGEL
CYP33C10P Caenorhabditis elegans (nematode worm)
GenEMBL AF016676
F41B5.a
contains first two exons split by 3700bp and no C-terminal sequence.
CYP33C11 Caenorhabditis elegans (nematode worm)
no accession number
Y49C4 contig 103
CYP32C12P C. elegans
CYP33C13 Caenorhabditis briggsae
XP_002647297.1 V_random + 373194-374835
MMFLFIIPIIFLWLFYELYYKRWNYPPGPIPVPFVGNIIPFIWDKPGYECFRKWNKTYGDVYTFWLGPSP
YVMIGSYELMKETFVKDGDTYTDKLQQPFTEKFRGGKFGIIETSGHFWSTHRRFALSTFRNFGLGKDLMQ
QKILLEIEEFFKVVDKNIEEEQDVPKEIYNTVANVINQLVFGYRFDEEKQEEFQKLKDLIDIQEKSFTSF
KYCIQAFAPGIGKYLPGKSLDDIITEKREDYYSFFYAQIAEHRLKIDFESEDVLDYAEAYLKEQKRQEEK
GDTELFSNQQLANMCFDLWFAGLTTTHTTLTWTVAYVMNHPEVQERIHKELDRVIRDDKRLVTTADKNEL
PLINAVINESQRCVNLLPLNLFHATTKDTIINGYPVKKGTGVIAQISTVMLDEKVFPDPYAFNTDRFLDE
EGKLKKIDELIPFSIGKRQCLGEGLARMELFLFIANFFNRYQVLPPATGPPSLEKAEKVGVFPRKFHAVL
KRRNVK
CYP33C14 Caenorhabditis briggsae
XP_002635535.1 V + 1982777-1985243
MFVILFFTVFAVYLGYELYWKRRNLPPGPCPLPVFGNLLSINNPPPGYAAFEGWTKKYGDVYTFWIGSRP
HIMINTYDKVKETFIRDAETYTNKVCLPAVDFFRGGDHGVIDSNGAKWRDHRRFALTSLRDFGLGKNLMQ
EKILLEVQDVFVKFDATEGQETEIPPVFDNAIANVINQLLFGYRFDETKQDEFQELKRIIDAPPELFGKL
HIFLAMNIPILAKLMPESLYEKPFKDFRDTGFGFFRAQVEKHREQIDFEDLDSDSSDYVETYLKEQRKRQ
NEGDEGTFSNIQLENMLMDMWFAGLGTTTNTTTWALSYILHYPKVQMKIHEELDRVVASDRLITTADKND
LPYMNAFLNETQRCTNLVPLNMQHETTKDTVINGYHIPRGTGVVAQISTIMMDEKTFPDHESFKPERFID
ENGKLKKVEQLVPFSVGKRQCLGEGLARMELFLFIANFLNRYELSPSKQGPPSLEKKCATMVEPRIFSGI
LKKRR
CYP33C15 Caenorhabditis briggsae
XP_002635642.1 XP_002635630.1 found in two locations
MFVILFFTVFAVYLGYELYWKRRNLPPGPCPLPVFGNLLSINSPPPGYAAFEGWTKKYGDVYTFWIGSKP
HIMINTYDKVKETFIRDADTYTNKVRLPALDLFRGGDHGVIDSNGVKWRDHRRFALTSLRDFGLGKNLMQ
EKILLEVQDVFAKFDATEGKETEIPPTFDNAIANVINQLLFGYRFDETKQDEFQELKQIIDAPPELFGKL
HMFLAMNIPILAKIMPESLYEAPFKDFRDSAFAFFRGQVEKHRQQIDFEDLESENSDYVETYLKEQRKRQ
NEGDEETFSNIQLENMLMDLWFAGLGTTTNTTTWALSYILHYPKAQMKIHEELDRVVASDRLITTADKND
LPYMNAFINETQRCTNLVPLNLQHETTKDTVINGYHIPRGTGVVAQISTIMNDEKTFPHHESFKPERFID
KNGKLKKVEQLVPFSVGKRQCLGEGLARMELFLFIANFLNRYELSPSKQGLPSLEKKCATMVEPRIFSGI
LKKRR
CYP33C16P Caenorhabditis briggsae
XP_002635643. XP_002635629.1 found in two locations
FRDIQLVNMCIDLWFGGLATTTNTTTWAISFVLQNL
EVQDKIHQELDRIIGSDRLITTADKNDLPYLNAYINESQRFTNLVPLNVPHATTRDT
VINCYSIPKGTGVVALISTVMNDE*VFPEHTKFK
PERFLDENGKLKK
VEELIPFSIGKRQCLGEGLARMELFLFISNFFNRYQISPSKNGLPSMDKSSISRIETRLFSAVLKRRR
CYP33C17 Caenorhabditis briggsae
XP_002636002.1 V - 4132548-4135425
MILFLLFTGLVAYLFHELYWKRRNLPPGPIPIPLIGNMLGLVMEKPGYECFRRWTKKYGDIYTFWL
GTTPYVMIGTYDKIKETFIRDGDTYKDKYPQPFNEKFRGGTYGIVETNGHLWSTHRRFTLTNFRDFGLGKDLMQQK
ILIEVEEAFRKFDEHLGEEQDVPAVVNNAVASVINQIVFGYRFDGEKQEEFEKLRDLMEYQEKAFTTFKV
HVQVFAPKIGQWLPGKSLDDLLGEWKANFHTFFNTQIENHRQKIDFDSEENLDYAEAYLKEQRKQEAAGE
FELFSNKQLMNTCLDLWFAGLSTTNTTLNWIICYIMNTPGVQEKMQEELDRVVGGDRLVAMSDKNELSYM
NAVINESQRCANIVPINLFHATTKDTVINGYPIKKGTGVIAQISTVMLDEETFPDPYKFNPDRFIDEDGK
LKKVEELCPFSIGKRQCLGEGLARMELFLFISNMFNRYKVSPSSEGPPSIDKTEKVGVFPRKFNAILTKRH
CYP33C18 Caenorhabditis briggsae
XP_002636007.1 V - 4148928-4150926
MIFILVLLSTLLLIYLFHLLYWKRRNLPPGPTPLPKFGNWLSMVFPLS GYECFRRWTKKYGDVYTFWLES
EPYIIIGSYERMKETFIRD GDTYVNKKFNEVIASFRDGQYGVVDTNGEFWSTHRRFTLSNFRDLGFGKDL
MQQKILIEVQEIIRKFDENVGEEQNVPKVFNKAVANVINQLIFGNRFDDEKEKEFQKLMDLLEYQQKAFT
SWKIIVECVVPFLSRFMPKPTVADLIEEYKTSFYGFFNRQIEEHRLKIDFDSEENESYAESYLKEQRKRE
ADGDKETFSTQQLSNMCMDLWLAGLGTTTLTLGWSMAYVMNTPGVQEKMHEELDRVIGSDRLISTSDKND
LPYMQAVINECQRCANIVPINLFHETTRDTVIAGYPIEKGTGVIAQISTVMLDETIFPDPYKFNPDRFID
EHGKLKKVEELCPFSVGKRQCLGEGLARMELFLMLANFFHRYEISPSSTGPPSIDKTQALRVTPREFDAV
LTKRH
CYP33C19 Caenorhabditis briggsae
XP_002636020.1 V - 4182816-4185053
MIFLLLFTTFGSWLFHELYWKRRTLPPGPTPLPLFGNILALSAEKPGYEAFRK
WTKVYGDVFTFWM
GTKPYIIISSYSRLKETFIRDGETYMNKVQLHFQEFIRDGYYGV
IAETNGEFWSTHRRFALSTLRNFGMGRDLIQEKILIEVEDMFKKLDEDIEKEQEINPVFN NAVANINNQLIFGYRFEKEKLKELEK*TELMEYQEKFFTTFRTNFQIFVPQLAWLIPGKT LEEGLVDWKTDFFDFFHKQIKAHREKIDLDSDESQDYAEAYLKEQKRRIKDGDKETFSDK QLSNMCLDLWFAGLSTTSITLTWTITYILHNPDVQKKLHEELDRVVGNNRLISTSDKPEL QYMNAVINESHQCVNLVPVNLFHCTSRDTVLNGYQVPKDTGVIAQISTVMLDEEVFPDPY KFNPDRFIDENGKLKKVEVLCPFSVGKRQCLGEGLASMELFLLVANFVNRYK
IKPYVHGLPSLDKSKNVTVVPRKVVAKLIRRHVQIDGLFVKNYFE*
CYP33C20 Caenorhabditis briggsae
XP_002636021.1 V + 4185548-4187702
MILLLLFTTLSLWLFHELYWKRRNYPNGPLPLPVIGNMVPIMKAKPGYEAFRQWTKEFGDVFTFWLGTKP
YIVVSSYKRLKETFILDGDTYADKAYQPFQEQFRGGQYGVIDTNGHVWSTHRRFALTTFRDFGLGKDLMQ
QKILIEVDEIFRKFDENIGKEQEIPGVFYNAGANVINQLIFGYRFDEEKQEELKKLKALMEFQETAFTTF
KVQVQFFAPIVGRMLPGKSVEELLAEFTVDFYKFFDHQIEEHRSKIDFDSEENLDYAEAYLKEQKKKESE
GDMELFGNRQLSNMCFDLWVAGLSTTHTTLSWIIAYVLNHSEVQKTMQIELDEVIGSDRLISTGDKNNLP
FMNAVINESQRCANIVPLNQIHCVSKDTMINGVLVKKGTGIIPQISTVLLDETTFPDPYKFNPERFIDEH
GKLKKVEELCAFSVGKRQCLGEGLARMEMFLFISNFFNRYQVTPGSSGPPSLEKETMFNATPRKIRAVLT
KRYL
33D Subfamily
CYP33D1 Caenorhabditis elegans (nematode worm)
GenEMBL Z92804
K05D4.4 (previously found on F10A3 and F11A5 at early stages of
sequencing)
CYP33D2X Caenorhabditis elegans (nematode worm)
GenEMBL Z92830
F11A5
this sequence is really the same gene as CYP33D1
CYP33D3 Caenorhabditis elegans (nematode worm)
GenEMBL Z81487 (C54E10), AL021470 (Y17D7A.4) and Z98877 (Y69H2)
GenEMBL AL020988 (Y80D3)
CYP33D4 Caenorhabditis briggsae
XP_002645739.1 74% TO CYP33D3
MILILILSFVFLYIFYELHWKRRNLPPGPTPLPFLGNLLELNKLKPGYEAFAKWKKKYGSVFTFWMGKKP
FIIICSYDKLKETFVKDGETYVDKQLGAIDKERLGQNYGVLDTNGEMWSVHRRFTLTQLRDLGLGKDLMQ
EKILMEVQELYKDIDAHGGAKFDFPALIDRSVGNVINLSLFNKRFETARRDEFAHLKSLIDGMRDVVSEF
RYFIQFLVPWTSKILPSPTLGEKVKERRTMLDDFFYSQIDEHMMEIDFESDENFDFVEAYLKEQRKREED
GDKETFSRKQLCAMCFDLWIAGLLTTTSTLTWGISYYLHDAKIREKIHDELDRVIGSDRLITTADKNQLP
YLTAFMNETQRCANIIPLNLLHITTRDTVIDGYNIEKGTGVIAQISTVMLDEQTFPEPFRVNPDRFLENG
KLKKVDEFIPFSIGKRQCLGEGLARMELFLFFANIFNRYNVLPAGKMPDLDKSQHNFVLPRKFEAVLERR
LKD
33E Subfamily
CYP33E1 Caenorhabditis elegans (nematode worm)
GenEMBL U61945
C49C8.4
CYP33E2 Caenorhabditis elegans (nematode worm)
GenEMBL U61952
F42A9.5
CYP33E3P Caenorhabditis elegans (nematode worm)
GenEMBL U61952
F42A9.4
missing C-terminal 3' neighbor is C49C8 (with CYP33E1)
CYP33E4 Caenorhabditis briggsae
XP_002634663.1 XP_002634664.1 IV - 12699946-12707750
MIFLLIFALFLIYSFDLFYWKRRNLPP
GPLPLPIIGNLYLMTDDVKPGYKMYQKLK
RDQYGPVFTFWLANLPMITVTDWKLIKQHFIKDGANFVGRPEFPINIEIR
EGPYGIVESHGDRWVQQRRFALHILRDFGLGKNLMEEK
VLSEVSA
MIESIRKIKDDVDMQNVFDAAVGSVINNLLFGYRYDETNMSEFLELKNLMSKHFKITAEPIGALLIMYPW
IGDLPFLGKYKRI
svVTDSWSGLLKMFRKQAEEKLAVIDYDSDDYSDYVEAFLKERKKHENEEGFGGFE
LEQLDSVCFDLWVAGMETTSNTLYWSLLYVLLNPEVCQKVYEELDMKIGNDRIITTSDRP
NLNYVMATIN
ESQRLANLLPMNISRTTACDMEIGGYRIPKDTVITPQICTVLYDPE
VFPEPYEFRPSRFLDSLGNLKKVEELVPFSIGKRQCLGEGLARMELFLFFANLFNKFDIK
LHADNLNPSIEKECGVTMKAKNFRVVMKERY
CYP33E5 Caenorhabditis briggsae
XP_002634646.1 IV - 12849096-12856099
MILLILGSLLFLYLFDCFYWKRRNLPPGPLPLPVIGNLHLLTDEMKPGYKLYAKLKEEYGPVFTFWMAKL
PMVTVTDWKLIKQHFIKDGGSFVGRPDFPISIEIRKGSYGIIESHGDRWVQQRRFALHILRDFGLGKNLM
EEKVLNEVTAMIESINKCKDNVDMQVIFDASVGSVINNLLFGYRYDEANMAEFLELKERMNKHFKMAAEP
IGGLIGMYPWLGSLPILSGYKSVVTDNWGGLMKMFRKQAEEKLAVIDYDSDEYSDYVEAFLKERKKHENE
EGYGGFE
MEQLDSVCFDLWVAGMETTSNTLYWSLLYVLLNPEVCQKVYEELDMKI
GNDRIITTSDRPNLNYVMATMNESQRLANLLPMNLSRTTTAEVEIGGYRIPKDTVITPQISSVMYDPEIF
PEPYEFRPSRFLDSLGNLKKVEELVPFSIGKRQCLGEGLARMELFLFFANLFNKFDIKLHPDNLNPSIEK
ECGVTMKAKNFRVVVKKRY
34A Subfamily
CYP34A1 Caenorhabditis elegans (nematode worm)
GenEMBL Z81119 and AL022301 (Y75B12)
T10H4.10
There are two P450s listed in this clone as one gene
This is the first one
CYP34A2 Caenorhabditis elegans (nematode worm)
GenEMBL Z81119 and AL022301 (Y75B12)
T10H4.11
There are two P450s listed in this clone as one gene
This is the second one
CYP34A2 Caenorhabditis briggsae ortholog
XP_002638424.1 XP_002638425.1
MFLILLITTILAVALVHQWRARRQLPRGPFPLPIIGNLHQLLFYCWKNGGIIEGYAEIEKSFGKVYTLWI
GPLPTVFISDYDVAVETHIKRANVFGKRYAPGIMNYIRFDKGVVASNGDFWQDHRRFALTTLRNFGFGRN
IMEERIMDEYRYRFEEFSSTGNNNRSGSFTTCARSFFDLLTGSVINKILINERFGRDDQDFQKLKTSLSK
GLEQTGFLDIFCPVDILMSKWLAWKQGPIFESFDWILELTKRHIARRVSQIESGEHILHDEPDDFLDAYL
MKKEKDEREGLETLLQNLAVDMYDLWLAGQETTSTTLTWACVCLLNKPEVIQKAREELIHVTGGNRSLSL
IDKKVTPYLAAVISEVQRISSIVNVNLFRIIEQDTVIDGQPLRAGTAITAHIGMIHVDEDLFKNHLEFDP
ERFIREEGLDKKLIPFGIGKRACLGESLAKAELYLVLGNLLIDYNLEPVGNVPSMKSITPFGFLKRPEQF
DVKFVAVK
CYP34A3 Caenorhabditis elegans (nematode worm)
GenEMBL Z81047 and AL022301 (Y75B12)
C41G6.1
CYP34A4 Caenorhabditis elegans (nematode worm)
GenEMBL AF068712
T09H2.1
CYP34A4 Caenorhabditis briggsae ortholog
XP_002636030.1 V - 4222164-4223954
MFLILFFSTIITVLVVHQWMKRRRLPK
GPLPIPFFGNLHQLFYFYWKYGGAVAAYRHLEQEYGKVFTVWIGPLPTVYISDYDIAHET
HIKRGNVFGARFAVGALNYIREGRGIVASNGEFWQEHRRFALKTLRDFGLGRNLMEEKIM
EEYRYR
FSQTSNGINNKSSIETNSSMFFDLLIGSIINQLLISERFEQ GDPEFEKLKKSLSVGLEKFGVLDIFLPDWIMNAWWMKWRMDDILGPFSWIH
RLSARNVNRRMEMIESGEHVIDGDGTDFMDAYINKSEKDKREGVNSTFT
LENLAIDMYDLWIAGQETTSTTLSWACACLLNHPEVVQKARDELVHLTGGHRSVSLTDKT
QTPYLNAVIN
EVQRIASILNVNIFRQTSEDTIVDGQPIAAGTALT
THLALIHTDETLFKDHTKFNPERFLENSCLEKKLIPFGIGKRSCLGESLARAELYLVLGN
MILDYDLEPIGEIPQIKTTSPFGIMKRPPVYSLRFVPVHHG*
CYP34A5 Caenorhabditis elegans (nematode worm)
GenEMBL AF039050
B0213.10
CYP34A6 Caenorhabditis elegans (nematode worm)
GenEMBL AF039050
B0213.11
CYP34A7 Caenorhabditis elegans (nematode worm)
GenEMBL AF039050
B0213.12
CYP34A8 Caenorhabditis elegans (nematode worm)
GenEMBL AF039050
B0213.14
CYP34A9 Caenorhabditis elegans (nematode worm)
GenEMBL AF039050
B0213.15
CYP34A10 Caenorhabditis elegans (nematode worm)
GenEMBL AF039050
B0213.16
CYP34A10 Caenorhabditis briggsae ortholog
XP_002636034.1 V ? 4237002-4238679
MLIILLLVTLLAVATAYQWKKCQKLPK
GPTPLPIIGNFHQFVYYG
LKLGSAVAVYHHFEKVHGKVFTLWMGLLPTVYISDYDIAHETHIKRANIFSNRFATGTTQ HIRHGRGIIASNGEFWQEHRRFALTTLRNFGLGRNIMEEKIMEEYHYR
VADYTKTHTKNGAIEIHAGTFFDLLVGSIINQLLISERFEQDDQEFEKIKSALAESL
ENFGIVDIFFPCWFLETPLMAWRQKKIFKPFDFVYEVSVRNIAKRVAAVESGEHVIEDGG
NDFADAYLLKIQKDQRDGVKSTFD
YETMAIDVFDLWQAGQETTSTTLTWAFACLLNHPEVAKKLRAELMKLTGGNRTISLTDRPD TPYLNATCNEVQRIASILNINLFRHIEEDTVIAGQPLAAGTALTTQMSMLHTDEAVFKNA TEFKPERFLENSNLEKTLIPFGIGKRSCLGESLARAELYL
ILSNLILDFDIEPVGTVPPIKTLNPFGLLRRPPTYNIRFKPVKH*
CYP34A11 Caenorhabditis briggsae
XP_002636094.1 V ? 4432270-4434247
MLTVLILISIFSIFVVRTWRASRKLPR
GPTPLPLIGNIHQLVYTC
WKAGGVVAGLNEFKKQYGKVFTVWIGPVPTVHISDFEIAHETHIKRANMFGARYLPEMID YIREGRGIVASNGDFWQEHRRFALRTLRDFGLGRNIMEAKIMEEYRYR
FDDFRKTNFKNGGIEVDAANCFDLLVGSIINTLLISERFEQGDKDFDELNTSLAEGFE
SASILDAFTPSWLMKSDFWKWRSKTICRPFDLIYAQVDKGIKKR
LEDVANGKHIIGEEGDDFVDAFLIKMEKDKMDGVTDSTFN
PETMTIDMYDLWIGGQETTSATLTWACACFLQHPEVVQELREELLGVTGGTRGISLTDKPN
TPFLNVTIN
EIQRIASILSMNLSRQVKEDTVIDGQPISAGTIVTTQMSMIHTDETVF
KNHTEFNPKRFLENNNLDKSLIPFGIGKRVCLGESLARAELYL
ITGNLVLDFNFQPVGQKPEIKTRSPFAMMKRPPHYGIRFVPLN*
CYP34A12 Caenorhabditis briggsae
XP_002636033.1 V ? 4232695-4234460
MLLFFVLTFVIGVLTINLWRARRKLPK GPTPLPLIGNFHQLAYTCWKAGGTVAGYNEFRKEFGKVFTIWLGPLPTVHIADIEVAHET HVKRANIFGVRYSNGGINYIREDKGVISSNGEYWQEHRRFALTTLRNFGLGRNIMEEKIM EEYRYRFQDYKRTNFKNGGIEVHASSCFDLLVGSIINTMLVSERFEQGDEEFDYMLESVE RSLGRLSIFDSFTPPWILKSDWWQWRTKYVFGGLEFLLGMAKRQIERR
VEAISNGEHAIGEDAEDFLDAFLIKMDKDKRDGIVDSSFN
LDSLAIDFFDLWLAGQETTSTTMVWACVCLLNHPEVVAELRRELLEVTGGTRCLTLRDKP
NTPYLNATIN
EIQRIASIFNTNIFRILEEDALIDGQIVSAGAVFTA
QISLLHTDEAVFKDNTKFDPGRFMENNNLEKNLIAFGLGKRSCLGESLAKAELYL
ITGNLILDFDLEPIGPVPEIKTTTPFGLMKRPPSYNIRFVPIEK*
CYP34A13P Caenorhabditis briggsae
V 4231472-4232566
PVPVXXXXHTIGYYAWKAGGIVAGFREIERIYGKIFTLWMGPIPTVPIADFEIAHETHVK
RAHTFXXXXXXX GPMNFIRERRGIAASNGEFWQEHRRFALKTLRDFGLG LKTLAIDLFDLYVVGQETTSTTLTWAYACLLNHPEVVEELRKELVGVTGGTRGVSLTDKP
NTPYLNATVNXXXXXX
SILNINLFRQLQEDTVIDGQPVSAGTVVTTQLSLLHTNEAVFKNHTVFNPNQYLENSYLE
KTLIPFGIGKRACPGESLARAELYL
IIGNLVLEFNFEPVGMKPEIKTASPFGSMKRPPNYHIRFVPVNN*
CYP34A14 Caenorhabditis briggsae
XP_002636032.1 V - 4229054-4230997
MFFVLILSAVFAVLAVNLWRARQRLPK
GPSPLPLIGNLHQLVYTCWKAGGTVGGFNEFRREFGNVFTIWMGPIPT
VHITDFDVAHETHVKRANTFGVRWANGGMNYIREGRGIIASNGEFWQEHRRFALKTLRDF
GLGRNIMEEKIMEEYNYR
FQDYKKNNFKNGGIEVHASSCFDLLVGSIINTLLVSERFEQDDEDFEKMKLNLAK
TLEKVSIFDAFTPLAVFKSDLWKWRTKKIFGPFDFIFGMVQKGIQKR
RVDAIASGKHIISEEGEDFVDAFLIKMEKDKKDGVKDSTFT
LETLAIDLYDLWLAGQETTSTTLTWACACLLNHPEVVAELRSELVGITGGTRGLSLTDKP
NTPYLNATVN
EIQRIASILNTNLFRELEEDTVIDGQPVSAGAVVTTQMSLLHTNEAVFKNHTVFDPSR
FIENNNLEKTLIPFGIGKRACLGESLARAELYL
ITGNLVLDYNFEPVGTKPEIKTLSPFGLMKRPPNYNIRFVPVNN*
CYP34A14-de7c Caenorhabditis briggsae
V 4228265-4228330
IKTPTPFAIMRRPPLYNIRFVP
CYP34A14-de6b7b Caenorhabditis briggsae
V 4228478-4228827
TLSFSNTLTDETLFKDHTKFNPSRFLENNNLEKKIIPFGIGKRSCLGKSLARAELYL ILGNLVMEYDLELVGEKPEIKTPTPFALMNRPPLYDIRFVPRRN*
CYP34A15 Caenorhabditis briggsae
XP_002636031.1 V - 4224268-4227419
MFLFLIFFSTLTYFCLNLYRRRQKNPN
GPIPLPLIGNLHQIAYYAKKTGGIVPAFNEFKKQYGNVFTLWMGPVPSVYIADFDIAYET HVKRVNVFGHRYTIGGMDYIREGRGIVGSNGDFWLEHRRFALTTLRNFGLGRNIMEEKIM
DEYRYR
IQDFSKTHAIGKESFEVSAATFFDILVGSVINQMLVSERFEQGDEDFQKLKVSLAK
SLEELSPIDMFTPLSILKSPLWRWRTKVTLAPFDFVLEMVSKGIKRR
MAAIENGTHVVNEEGDDFVDAFLVKINKDQKDKILDSSFT
LDTLAIDLYDLWLAGQETTSTTLTWAVVCLLNHPEVVEELRKELDGVTGGTRGVSLTDRS
KTPFLNATIN
EVQRIASILNINPFRHLQEDTVIDGQPIAAGTCVTANLAQFHSDEELFKEHTKFKPE
RFLENNNLEKKLIPFGIGKRSCPGESLARAELYL
ILGNLVMEYNLESVGLVPEIKSPTPFALMKRPPIYDVRFVP
CYP34A16 Caenorhabditis briggsae
XP_002636141.1 V + 4630347-4632348
MLFLLIFVTTLAIWTVYLWRATQRLPK
GPFPLPLIGNFHQLAYTCWKAGGTVAGFHEFKKQYGKVFTIWLGPQPTVHITDIEIAQET
HVKRANVFGHRYSNGGTDYIREGRGIVASNGEFWQEHRRFALKTLRDFGLGRNLMEEKIMEEYRYR FQDFKKTNFKNGGIEVHSDSCFNLLVGSIINTLLVSERFEQNDADFEKLLETGTVALE
KMSVLDSFVPLWLMKSRAWQWRTKKVFGPFEFVHGLVERKIQQR
RVKEIESGEHTMSETGEDFVDAFLIKMEKDKKDGVKDSTFT
LENLAIDLYDLWLAGQETTSTTMVWACACLLNHPEVVGELKRELVGVTGGTRALSLTDKP
NTPFLNATIN
EVQRIASILNSNLFRQLEEDTVIDGQPVSAGALVT
VQLSALHTDEAVFKNHTKFDPKSLMKNRNLEKNLIPFGIGKRSCPGESLARAELYL
ITGNLILDFDLEPVGPAPEIKTTAPFGLMKRPPSYDIRFVPIEK*
35A Subfamily
CYP35A1 Caenorhabditis elegans (nematode worm)
GenEMBL U97008
C03G6 near 19k
CYP35A2 Caenorhabditis elegans (nematode worm)
GenEMBL U97008
C03G6 near 22k
CYP35A3 Caenorhabditis elegans (nematode worm)
no accession number
K09D9
CYP35A4 Caenorhabditis elegans (nematode worm)
GenEMBL AF016418
C49G7.8
CYP35A5 Caenorhabditis elegans (nematode worm)
GenEMBL AF039049
K07C6.5 [and part of F40C5 contig 6 9-578 plus strand Note:
newest version of
F40C5 does not contain this P450. probably an error corrected by the
sequencers]
NOTE: K07C6 IS NOW IN GENBANK AND IT CONTAINS 4 P450S
It is part of a contig with T09H2 and B0213 that has 13 P450s in a
cluster
6 P450s on B0213 appear to have inserted themselves into a cluster
of
three olfactory receptor-like genes. K09D9 is the next clone 3' and
it has at least
one more P450. C49G7 is next with one more P450
Contig order K07C6 T09H2 B0213 K09D9 C49G7
CYP35A6 Caenorhabditis briggsae
XP_002635212.1 V 292452-294169
MIISILLTAIVLWIVIQHYRRVSRLPPGPFSLPILGNIPMIFYYAWRAGGVVPMMSMMKRKYGNVFTIWI
GTIPHVSVTDFETCHEVFAKSGNRFSDKAFSPIFNEARNGFGMIAINGSIWQEMRRFSLQTFRNMGIGKD
LMELRIMSELDLRCREIDEESIDGVTEVNATEFFDLIAGSIINTLPIGSRFEKGNSHHFLRLKMLIEEST
KVLSPIDVMLPIWFLKIFLKRRYSLVMKAHRDILDFLAKDAIQRVEDVLNGKIEINPENPADYIDSFILK
ILQKDSDKNTFSILSLKSVLTDLWIAGQETTATTLVSGFCQLLNHPNVMEKIRNELLHVVGSRPLTLKDK
SETPYLNAVIAEIQRHASILNINFFKINHEVTEIGGHPVDAGALVTAQLSSLHSDETTYSNPNVFDPEKF
VNDKNLSQKLIPFGIGKRACTGEALARAELYLIIGNLLLRYKFQPSGPLVSNIDDAPYSFAKKPRGYKMQ
LIKI
CYP35A7 Caenorhabditis briggsae
XP_002636137.1 V 4616588-4618404
MFFVLIISFFLTWLVVRQYQKVSRLPPGPVSLPLIGNLPQIVYYLWSTGSVVSTLDLFRK RYGKIFTLWVGPIPHVSIVDYETAHEVFVKNGNKYADKFHAPLFQEIK
KDQGVLSTNGDHWQEMRRFALQTFRNMGVGKDVMELKIIEELNAR
CADIDKAAVNGVTTTQASEFFDLTVGSIINNILVGKRFDKNTKGEFLKIKN
AFELFTPFDMTVPIWVLKTFFSKRYNNLISLNDETTGFVAKEAEAR YAQMKSGQYSVDENNIQDYSDAFLLKIQKDGENKNFK IETLKTMIIDLWITGQETTTTTLISGFNQLLLHPEVMEKARVELMKITENGSRDLSLSDRPKTPYLN AMIAEIQRHASILNINFWRINHEPTNMGGHMVDSGAFVTAQLSALHINETVFEDPQKFDP
ERFVRDESLLQKVIPFGVGKRACLGESLARSELYL
IFGNLLLRYNFKPHGKLSTQEVMPYSFAKRPFKLEMQFVKI*
CYP35A7-de7b8b9b Caenorhabditis briggsae
V + 4618814-4619204
ICFWR*NREPTYMGGHMMDSGALVTAQL DVLHVNETVFEHPEKIDPQRFIRDEKLLQKVIPFGIGKRTCLGESLSRFELHL
IFGNLLLRYKLQPHGELSTKNLMPYSAGKRPFKLEMQFINI
CYP35A8 Caenorhabditis briggsae
XP_002636139.1 V + 4624954-4626736
MFFILVISFVLTWLVVRQYQKVSRLPPGPVSLPLIGNLPQIVYYLWSTGSVVSTLDLFRK
RYGNIFTLWVGPIPHVSIADYETAHEVFVKNGNKYADKFHAPLFQEIK
NDRGVVVTNGDHWQELRRFALQTLRNMGVGKDVMELKIVEELNAR
CADIDEAAVNGVTTTQASEFFDLTVGSIINNILFGKRFDKNTKGEFLKIKNALDSAFEL
FTPFDMTVPIWVLKTFFSKRYNNLITMTDETTSFVAKEAETR
YAQTKSGQYFIDENNIQDYTDAFLLKIQKDGENKDFN
IETLKTMIIDLWITGQETTTTTLISGFNQLLLHPEVMEKARAELMNITENESRDLSLSDRPKTPYLN
AMIAEIQRHASILNINFWRINHEPTYMGGHMVDSGTFVTAQLSALHINETVFENPQKFDP
ERFIRDESLLQKVIPFGVGKRACLGESLARSELYL
IFGNLLLRYNFKPHGKLSTVEVLPYSFVKRPFKLEMQFVKI*
CYP35A9 Caenorhabditis briggsae
XP_002636145.1 V + 4646141-4647941
MFLILLVSVFLAWLVVRQYQKVSRLPPGPVSLPLIGNLPQIVYYLWSTGGIVPTFDLFRK
RYGNIFTLWLGPIPYVSIADYDTAHEVFVKNSNKYADKFIAPLFQAIR
NDKGVAGTNGEHWQEMKRFVLQTFRNMGVGKDVMELKIIEELDAR
CADIDKAAVNGVTITQASDFFDLTVGSIINNILVGRRFDEDNKEEFFKVKHSADSAIEI
VSLFDMMLPVWVLKTFFKAHYDTVINSNEETRDFVGKEAEIR
DNQIKSGKYSIDENNVKDYTDAFLLKIQKDGENKDFN
IETLKTMIVDLWTTGQETTTTTLISGFNQLLLHPEVMHKARSELMEITENGSRNLSLTDRPKT
PYLNAMIGEIQRLASILNINFWRINHEPTYMGGHMVDSGALVAAQLSALHINETVFENPE
KFDPERYIRDEPLLQKIIPFGVGKRACLGESLARAELYL
IFGNLLLRYNFKPHGKLSTADVFPYSFAKRPFKLEMQFVKIRS*
CYP35A9-de8b Caenorhabditis briggsae
V 4642983-4643048
ISFGVGKHTCLGESSARSELYW
>CYP35A9-de9b Caenorhabditis briggsae
V 4638516-4638560
RPFKLEMQILKIHHL*
CYP35A10 Caenorhabditis briggsae XP_002636136.1 V ? 4648726-4650542
MFFVLIVFTFLTWLVVRQYQKVSRLPPGPVSLPLIGNLPQIVYYLYTTGGVVSTLDFFRK
RYGNIFTLWVGPIPHVSIADYETSHEVFVKNANKYADKFHSPIFREMRSKR
GILTANGDHWQEMRRFALFTFRNMGVGKDLMETRIMEELNAR
CADIDKAAVNGVTTTQAAEFFDLTVGSIINSILVGKRFEEHNKNDFLKIKEVMDA
SFETFSPFDMTMPVWILKNFFPRRFEKMRNGQESSKQFAAKEALKR
IDEIKAGRYVIDENNFQDYTDAFLWKMQKDGENEDYK
VESLKTMILDLWITGQETTTTTLISGFNQLLLHSKFMEKARAELFEITENGSRNVSLSDRPKTPYLN
AVIGEIQRHASILNVNFWRWNNEPTYMGGHMVDSGALVTAQLSALHVNETVFEHPEKFDP
ERFIRDEKLLQKVIPFGLGKRSCLGESLARSELYL
IFGNLLLRYKFQPHGELSTREIMPYSAGKRPFKLEMQFIKV*
35B Subfamily
CYP35B1 Caenorhabditis elegans (nematode worm)
GenEMBL AF039049
K07C6.4, [F40C5 contigs 5 and 14 Note: newest version of F40C5 does
not
contain this P450. probably an error corrected by the sequencers]
CYP35B2 Caenorhabditis elegans (nematode worm)
GenEMBL AF039049
K07C6.3 [and F40C5 contig 15 Note: newest version of F40C5 does not
contain
this P450. probably an error corrected by the sequencers]
CYP35B3 Caenorhabditis elegans (nematode worm)
GenEMBL AF039049
K07C6.2
CYP35B4 Caenorhabditis briggsae
XP_002636134.1
MILVLIFTTLLAILIVRHYQKVRKLPPGPITLPLIGNNPQIVYYSWKNNGIVPAFEYFRK
YGNVFTLWLGPFPHVSIADFETNHEVFVKNGNRYKDRFLSPIFEELQ
DHGLVFANGEKWAELRKFTMVTFRNMGVGNEIMEEKIMEELDAR
CADLDNEAIDGKTVVEHGKLFELMVGSVINSLLVGNRFGEDNKEEFLHIRHLIETFNEV FTTFDMIMPVWVLKTFFPTRYAIAADGMNAIKDYVGRVAEKRFEEVKSGKYVLEETNPKD YVDAFLIKIQKEKDHPAYT
MKSLKYVLLDLWSAGHDTTATTLISGFNQFMHHPEVVRKCREELLRLTDGGSRPLSLKDR ADSRYLNATIAEIQRHASILNVNFWKTSDAPTKVNGYELDAGEILTAQMSALHVNEDIFK HAGEFMPERFLENEKLIHQLIPFGIGKRSCVGENLARAELFM
VFGNLLLRYNIQPHGKLPSTADQLPFSAVKIADTSAKLEFIKI*
CYP35B5 Caenorhabditis briggsae
91% to CYP35B6
MIFILLLTFFLAILIVRQFQKASNFPPGPTSLPFIGNIHQLIYYCWKHKGVVPAFDYFRQ
YGDVFTLWLGPIPHVSICDYETSQEVFIKNGNKYKDRFLPPIFEHVS
ENMGLISANGESWAEMRRFALLAFRTMGVGRDLMEERILAELDAR
CAKIDADAVNGKTIVHTSEFFDLTVGSVINSVLIGKRFDSHNKDEFLKLKGLLDSADELFTMFELTVPV
WLLKKCFPERYARIVEVQEEIINFVSREANERYEKVKSGEYTINADDPQDFVEAYLAKI
EEEKEKGTTNFYTMQCLKHVIG DLWLAGQGTTATTLVSGFNQLVNHPEVIMKCREELMRL
TNNGSRTLSLKDRADSHYLNATIAEIQRHASILNVNFWRYNHEATTIKGYPVDSGSVITA
QLGALHVNNDIFKNAGNFYPERFIEDPKLLNQVIPFGIGKRSCVGENIARSEIYL
MIGNLLLRYDIKPHGALPSTEDKLPYTAGKLPDKTVKLEFCKL*
CYP35B6 Caenorhabditis briggsae
XP_002636140.1
MIFILLLTTFLAILIVRQYQKAKKFPPGPTSLPFIGNIHQLIYYCWKHKGVVPAFDYFRQTYGDVFTLWL
GPIPHVSICDYETSQEVFVKNGNKYKDRFLPPIFEHVSENLGLVSANGESWAEMRRFALGAFRTMGVGRD
LMEERILAELDARCAKIDADAVNGKTIVHTTEFFDLTVGSVINSVLIGKRFDSHNKDEFLKLKGLIDSAA
DLFTIFDLTVPIWLLKKLCPERYAKIVESQVEIINFVSREANERYEKVKSGEFTINSEDPQDFVEAYLAK
MEQEKEKGTTNLYTMECLKHVIGDLWLAGQDTTATTLVSGFNQFVNHPEVVKKCREELMKLTDNGSRPLS
LKDRAESHYLNATIAEIQRHASILNVNFWRYNHEATTIKGYPVDSGSVITAQLGALHVNNDIFKNAEKFY
PERFIEDPKLLNQVIPFGIGKRSCVGENIARSEIYLMIGNLLLRYDIKPFGDVPSTEDKLPYSAGKLPDK
TVKLEFCKL
35C Subfamily
CYP35C1 Caenorhabditis elegans (nematode worm)
GenEMBL Z77652
C06B3.3
CYP35C1 Caenorhabditis briggsae ortholog
XP_002635205.1
MFLLLLIISIIAWLSARQYLKSKRLPPGPTSFPLIGNLHQIGYQLWKTGGMVATLNHYRKQYGDVFTLWL
GPIPHVNITNYEISHEVFVKNATKYADKHIPPLFDFIRQGNGVFFSNGDKWQELRRFSMLTMRNMGMGRD
LMEEKIIAELNTRCSELDAKSVNGTAVETVNVFFDLTVGSIINNMLMGFRFDERNKNRFLTFKHMVDKSM
EKFSATYLVLPVWILKTLFSKSFDELISDNFKLLDYVSEDAVKRSRDYIKGTYEIDPDNVEDFVDAFLLK
MKQDPKSEVYNEENLKMLVLDLWITGQETTTMTLISAFIRFLNNPDVMDKLRNELMKVTNGASRHLSLKD
KNETPYLNATLAEVQRHASILNVNFWRLNKEPTVIGGHPVDSGCLIAAQLSALHTNEKVFEDPEKFEPER
FLKNENLIQQVIPFGIGKRSCLGEALAKAELYLVRYAGSLIGLLRGEPLLNVTTSIGSDYIHFDRECIQQ
S
35D Subfamily
CYP35D1 Caenorhabditis elegans (nematode worm)
GenEMBL Z83105
F14H3 near 20k
CYP35D1 Caenorhabditis briggsae ortholog
XP_002638285.1, XP_002638288.1
MILLLSFCLLLIFWIISNFRKGSNLPPGPTPLPLIGNIHQLIYLIWKLNGIVPTLDFYRKKYGNAYTIWL
GPMPTVNITDYEMAHEIFVKNGKKCQDRQLAPVLEHISGGHGILAANGENWAEMRRFTLLSFRKMGVGSG
LMEKKIMAELDGRCSELDAEIDKNGKVTVPVDFFDLTVGSVINSLLVGKRFDENSKDEFLKIKKMFDDSS
ETFNLFDLNVPVWFLKWVLPWRFRITWDARQNILSHVGKEAVERFQKLKDGTYDLDSEEPKDLVDCFLAK
MRSENEKGQDGHPGY NMDALKLVLHDLWLAGQGTTATSLYVGFLKLVTHPSVILKIQKELLKITQGSRDL
TLQDRPNTPYLNATIAEIQRFTSVLNVNFWRINDELISFRGFQVPAGTMMTAQIGALHVNEQLFENPDEF
DPERFLRNEKLLQQLIPFGIGKRSCVGEQLARSELYLVLGNLLLRYDIRAHGALPTNMDVFPYSSAKLPD
TSGKFEFRKIQKT
CYP35D2P Caenorhabditis elegans (nematode worm)
GenEMBL Z83105
F14H3 near 14k
only N-terminal is present
36A Subfamily
CYP36A1 Caenorhabditis elegans (nematode worm)
GenEMBL Z83220
C34B7.3
CYP36A1 Caenorhabditis briggsae ortholog
XP_002639478.1 94% to CYP36A1 C. elegans
MLFAQLVILVVIVMLLLCRFANKIRGLPPGPTPWPFI
GNTFQVPEDRIDIIINEFKKKYGGIFTLWLPFPTVVICDYD
MLKRNIVRNGEAFSGRPDTFIMDMLVQGNYGLFFMENNWWKAQRRFTTHIFRSLGVG
QAGTQDTIASLASGLVEKIDNQKDSSIELRPLLV
HVVGNVIHKHLFGFTREWNETEILDFHVAINDVLEHFTSPKTQLLDAWPWLAYLDKPLSL
GIPRTTRANDAIIQNLEQ
ALAKHKSGINYDEEPSSYMDAFLKEMKIRAAETALEDGFTEKQLIVAIYDLYSAGMETI IIVLRFAFLYLINNPETQKRIHDELDKNVGRDR
QVVMDDQKQLPY
TCAFLQEVYRLGYVLPVNFLRCTLVDVEDCEGYRLPAGTRVIAQFQSVHVDKKHFPDPEH FNPDRFLN
ERGEYIRDDRINPFSMGKRSCLGENLARMEVFLYFCTLMQKFEWHTDGAFAPPIDVI
TSSLRAPKPFTIRASRR*
37A Subfamily
CYP37A1 Caenorhabditis elegans (nematode worm)
GenEMBL Z81493 (F01D5) and Z92851 (Y39G8)
CYP37A1 Caenorhabditis briggsae ortholog
XP_002631640.1 83% to CYP37A1
MGFAVYLVALVILYVLLNLGKIGKFVKERKRLYELMDKIDGPYALPLLGTTWQFKMDPVEFALQLYNWGL
EYSSKGASLAKFWMGPYPMVIILTPEASKFRSDCGAKNKNDNFQKVLESNVLINKSSEYDIFLPWLGTGL
LLASGDKWRGRRKMMTPSFHFNVLIDFQAVFDNQGKILLEQLEDEMRYAKDNTFDAFPYIKRCALDIICE
TAMGTTVSAQTNHTHPYVMAVNEMNSLAFKYQRMPWLWIKPIRHLSGYEADFQRNLDIVTSFTKKVIEGK
LREHEESVGFSEDKNKKKAFLDMLIDKKDEGGLGYEDIREEVDTFMFEGHDTTSAGIGWSLWCLANSPEY
QKKCHEELDQIFEGSPRECTVDDLKKMKYLEKCVKEALRMRPSVPQIARSVEEEFEIDGTIVPKGCSVMV
SPAFLQNNPRTYENHEVYDPERFNEDEIAKRHAYAYIPFSAGPRNCIGQKFAMQEEKTVISWVLRRFQIH
SDVGIRENIPLPETITRPTMGFPLKFTIRQ
37B Subfamily
CYP37B1 Caenorhabditis elegans (nematode worm)
GenEMBL Z93381 and Z93389
F28G4 and T13F3
CYP37B1 Caenorhabditis briggsae ortholog
XP_002638224.1 75% to CYP37B1
MQFLNLTIVFVLGLLIFYYKSIYNSIRDRLRIYHFLSKFDGPLAFPLVGNLYLVNIFDISKLVDQVLHLA
WYYCKKGCGIVRLWIGPVPMLAVVNPIYAKEILESNEVITKADEYEILFPWLGTGLLTSTGDKWRQRRKM
LTPAFHFKVLNDFLSVHDYQAKVFLEQIKQFADSGDEVDLFPYIKRMALDIICETSMGATVDAQNNHDHQ
YVESVRRLSEIGFLWIIYPWLKIKPIWYLSGYGAEYDRHLEIVLDFTKNVIEEKWTEYQQYQLGAEKKDK
RSMVFLDLLLQLRSEGLMNEEDIREEVDTFMFEGHDTTAASMGWTLWCIAHNPDIQEKVIEEVDRIFGGS
DRDCTNEDLKQMKYLEKCIKESLRMFPPVPFFGRKVEKDVVIHGNFLPKGVRIILVPLVLQRNPLLFENP
NVYDPENFSEEKMSSRHAYSDVPFSAGPRNCIGQKFAMMEEKTVISWFFRKYRISANVAFEDNKILPEII
MKSSLGFPVTITHRMDNK
CYP38A1 Suberite domuncula (sponge)
GenEMBL Y17816 (1789bp)
Mueller,W.E.G., Wiens,M., Batel,R., Steffen,R., Borojevic,R. and
Custodio,M.R.
Establishment of a primary cell culture from a sponge: Primmorphs
from Suberites domuncula
Mar. Ecol. Prog. Ser. In press
most similar to the CYP4 family
MLDFVIFAITAVAGLIGILLFFYFSRSTETKPVSSASPTSTIPR
WSAPPADIEKGDLDVMMKKHGSLHQFLLHLHDNGKTPVTSFWWGKTHVVSFCSPQAFK
ESAVFVNRPVELFVGFEPLITPFSIQYANDEDWVQRSKCLYHTLKGDDLKSYFHHFVQ
IAQEEESLWSSYTSDKEVSLTKEVFPMTIKGIARTCFGDIFKDENELSKMAESYHVCW
RTMEEGVPEAGSKRETEFLKHRRVLEDIIRRIIQERKEGEDLQELPFIDSMLQNYDSE
DKIIADAISFMVGGFHTSGYMFTWMLWYLSSHPESQDRLRTEIERETGGERGDRLKEY
SLRADTFLRQVQDETIRLSTLAPWAARYSDKKVTVCGYTIPAKTPMIHALGVGLKNKT
VWENTDSWDPDRFSPNGRRGNDFCPFGVHSRRKCPGYLFSYFEVGVFASILLSRFEIV
PVEGQTVIQVHGLVTEPKDDIKIYIRSRKED"
CYP39 human
GenEMBL EST R07010 R11279 and UNIGENE entry Hs.25121
covers the C-terminal part of a P450. The 2 ESTs with coding
regions
are not found in UNIGENE, but the opposite end of EST R11279 =
R11221 and it
is in UNIGENE with 13 EST sequences all from the 3 prime noncoding
region.
This sequence is most like CYP4A11, but the percent identity is only
39%. Since this is the most conserved region of P450s, the sequence
must be in a
new family. More sequence is known form the mouse homolog.
ENLLLIKWCVLETIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWEKGKFRRKHSFL
GTASWA
FGAGSSQCPGKVFALLEVQVC
CYP39A1 human
AC008104 AL035670 note heme region exon corrected 1/18/02
MELISPTVIIILGCLALFLLLQRKNLRRPPCIKGWIPWIGVGFEFGKAPLEFIEKARIK
YGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVYRT
ASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVR
HLLYPVTVNMLFNKSLFSTNKKKIKEFHQYFQVYDEDFEYGSQLPECLLR
NWSKSKKWFLELFEKNIPDIKACKSAKDNSM
TLLQATLDIVETETSKENSPNYGLLLLWASLSNAVP
VAFWTLAYVLSHPDIHKAIMEGISSVFGKAG
KDKIKVSEDDLENLLLIKWCVLETIRLKAPGVITRKVVKPVEIL
NYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERW
KKANLEKHSFLDCFMAFGSGKFQCPARW
FALLEVQMCIILILYKYDCSLLDPLPKQ
SYLHLVGVPQPEGQCRIEYKQRI
CYP39A1 Pan troglodytes (chimpanzee)
XM_003311351
99% (4 aa diffs) to human
MELISPTVIIILGCLALFLLLQRKNLRRPPCVKGWIPWIGVGFE FGKAPLEFIEKARIKYGPVFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVY
RTASIPKNVFLALHEKLYIMLK
GKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNNLVRHLLYPVTVNMLFNKSLF STNKKKIKEFHQYFQAYDEDFEYGSQLPECLLRNWSKSKKWFLELFEKNIPDIKACKS AKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLSNAVPVAFWTLAYVLSHPDIH KAIMEGISSVFGKAGKDKIKVSEDDLEKLLLIKWCVLETIRLKAPGVITRKVVKPVEI LNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKKANLEKHSFLDCFMAFGSGKF QCPARWFALLEVQMCIILILYKYDCSLLDPLPKQSYLHLVGVPQPEGQCRIEYKQRI
CYP39A1 Macaca fasicularis (cynomolgus monkey)
GenEMBL AB220544.1
MELIFPTVIIILGCLALFLLLQRKNLRRPPCIRGWIPWIGVGFE
FGKAPLEFIEKARIKYGPIFTVFAMGNRMTFVTEEEGINVFLKSKKVDFELAVQNIVY
HTASIPKNVFLALHEKLYIMLKGKMGTVNLHQFTGQLTEELHEQLENLGTHGTMDLNN
LVRHLLYPVTVNTLFNKSWFPTNKKKIKEFHQYFQAYDEDFEYGSQLPECLLRNWSKS
KKWFLELFEKNIPDIRACKSAKDNSMTLLQATLDIVETETSKENSPNYGLLLLWASLS
NAVPVAFWTLAYVLSHPDIHKAVMEGISSVFGTAGKDKIKVSEDDLEKLLLIKWCVLE
TIRLKAPGVITRKVVKPVEILNYIIPSGDLLMLSPFWLHRNPKYFPEPELFKPERWKK
ANLEKHSFLDCFVAFGSGKFQCPGRWFALLEVQMCVILILYKYDCSLLDPLPKQSSLH
LVGVPQPEGQCRIEYKQRI
CYP39A1 Canis familiaris (dog)
GenEMBL XM_538946.2
MELISPTVIIILGCVALLLFLQRKNLRGPPCIRGWIPWIGAGFE
FGKAPLEFIEKARIKYGPIFTVFVMGNRMTFVTEEEGINVFLKSKEVNFELAVQNPVY
RTASIPKNTFLALHEKLYIMMKGKIGTFNLYQFTGQLTEELHEQLENLGTHGTMELNH
LVRNLLYPVTMNMLFKKGLFPRNEGKIREFYQHFQAYDEGFEYGSQMPECLLRNWSKS
KKWLLALFEKNIPDIKTYKSAKDNSMTLMQTMLDIVEMERKEEKSPNYGLLLLWASLS
NAVPVAFWTLAFVLSHPSIHKTIMEGVSSVFGTAGKDKMKVSEDDLKKLPLIKWCILE
AIRLRAPGIITRKVLKPVKILNYTVPSGDLLMLSPFWLHRNPEYFPEPELFKPERWKK
ANLEKHAFLDWFMAFGSGKYQCPGRWFALLEIQICIILILYKYDCSLLDPLPKQSFLH
LVGVQQPEGQCRIEFKQRK
CYP39a1 mouse
GenEMBL ESTs AA096922, AA606237
Note: this sequence has a poorly conserved I Helix
consensus
QFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSAGHS
GTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVL
ESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVK
PVKILNHTVPSGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIF
LDYFMAFGGRKFQCPGKWFALLEIQLCIILVLYKYECSLLDPL
Cyp39a1 mouse
GenEMBL NM_018887.1 AF237981
39a1 (oxysterol 7alpha-hydroxylase) 72% to human
MGIMELFSPIAIAVLGSCVLFLFSRLKNLLGPPCIQGWIPWIGAGLEFGKAPLEFIEKARIKY
GPVFTIFAMGNRMTFVSEEEGINVLLKSEHVDFESAVQSPVYHTAWIPKNVFSALHERLY
ALMKGKMGTFNTHHFTGPLTEELHEQLEGLGTHGTMDLNDFVRYLLYPATLNTLFKKGLF
LTDKRTIKEFYQQFKTYDEGFEYGSQLPEWLLRNWSKSKRWLLALFEKNIGNIKAHGSA
GHSGTLLQAILEVVETETRQYSPNYGLVVLWAALANAPPIAFWTLGYILSHPDIHRTVL
ESISSVFGTAGKDKIKVSEDDLKKLLIIKWCILESVRLRAPGVITRKVVKPVKILNHTVP
SGDLLMLSPFWLHRNPKYFPEPESFKPERWKEANLDKYIFLDYFMAFGGGKFQCPGRW
FALLEIQLCIILVLYKYECSLLDPLPKQSSRHLVGVPQPAGKCRIEYKQRA*
Cyp39A1 rat
CYP39A1 Bos taurus (cow)
See cattle page for details
192 MEFISPTVIIILSCVAVLLFLQWKNLRRPPCIRGWIPWIGAGFEFGKTPLEFIEKARIK
YGPVFTVIVMGTRMTFVTEEEGINVFLKSKEINFELAVQNPVYHT
ASIAKNIFLKLHEKLYITVKGKMGIFNLYKFTGQLTEELQEQLQNLGTHGTTDLNKFMR
HLLYPVTVNILFKKGLFPTDERKIREFHQHFQAYDEGFEYGSQLPECLLR
NWSKSKKWLLALFEKNIPDIKTHKSAKENYP
TVMQAVLDLLEMEANEQKSPNYGLLLLWASLSHTVP
VAFWTFAFVLSHPNIHRTIMEGISSVFGTAG
KDKIKVSEDDLKKLPLIKWCILETIRLRAPGVIARKVLKPVKIL
DYTVPSGDLLMLSPFWLHRNPKYFPEPDLFKPERW
KEANLEKHAFLDCFMAFGSGKYQCPGRW
LALLEIQICIILIFYYYDCSLLDPLPKQ
SSLHLVGVQQPEGRCRIQFKQRK*
CYP39A1 Sus scrofa (miniature pig)
no accession number
Haitao Shang
Submitted to nomenclature committee May 23, 2007
partial sequence
80% to human CYP39A1, complete seq constructed from ESTs
Ortholog of human CYP39A1
CYP39A1 pig
ESTs BP441358.1, BP458693.1, CV872464.1, DN131248.1, CB287479.1
DN131598.1, CN156146.1, DN115951.1, BP166812.1, DN116306.1, CN154029.1,
MEFISPAVIIILGCVTLLLFLQWKNLRGPPCIGGWIPWIGAGFEFGKAPLEFIEKARIKY
GPIFTVLAMGTRMTFVTEEEGMNVFLKSKEVNFELAVQNPVYRTASIPKNIFLKLHEKLC
VMMKGKMGTFNLYQFTGQLTEELHKQLENLGTHGTMDLNNLVRHLLYPVTVNVLFK
KGLFPTNERKIREFHQHFQAYDEGFEYGSQ LPERLLRNWSKSKNWLLALFEKNI PDIKTY
KSAKDHSQTIMQDILDLLEMETNEQMSPNYGLLLLWASLSNAVPVTFWTLAFILSHPNIH
RTILEGISSVFGTTGKDKI
EVSEDNLKKLPLIQWCILETIRLRAPGVITRKVLKP
VKILNYTVPSGDLLMLSPFWLHRNPKYFPEPDLFKPERWKKANLEKHAFLDWFMAFGTGKYQCP
GRWLALLEIQMCVILIFYYYDCTLLDPLPKQSSLHLVGVQQPEGQCRVEFKQRK*
CYP39A1 Gallus gallus (chicken)
GenEMBL BG712800 BG710422 BU226060 AI979980 BU247492 BU226060
XM_420064.1
57% TO 39A1 HUMAN
MAAAVLLAALLAVAVVAWVLFPPSEP
RRPPCIGSRVPCLGAAF
RLARAPLEFIERARAEHGPIFTVFALGKRFTFVTEDEGAEVFFTSKDLNFEQAVQRVV
ANAVSVPAEAFYQNHGRLYSMMKGKMGPSNLHMFTGTLCKELHEHMAHLGTAGTGDLMEL
VRHIMYTAVVNTLFGKGACPTSHSELREFEEHFWKYDEDFEYASQMPECFLRNWSKSKKW
LLKLFEKVVSDAERTNPSETTSKTLLQHLLDNLQGK
HLAPNYGLLMLWASQANAVPIAFWTLVFILSSP
SVYKKVMEDLTSVFGNAGKDEIEVSEEDLKNLPYIKWCTLEAIRLRSPGAITKKVIKPIR
IQSFTIPAGDMLMLSPYWLHRNPKYFPDPEMFKPDRWKEANLEKNAFLDGFVAFGGG
NHQCPGRWFAIMEIQLLVALFLYKYEFVLLDAVPKESPLHLVGTQQPLTPFRVQYKGWE*
CYP39A1 Xenopus tropicalis (Western clawed frog)
CX851900.1 CX931743.2 CX956889.1
51% to human CYP39A1, a CYP39 ortholog
MDPIASVSSALLSPTAALGLLVALLTAVLVRYLLPNG
SQKPPYPPCIRGWIPWFGAAFDMGKAPLEFIARAREKHGPIFTVLAAGNRLTFLSGKEGI
SAFFSSKEADFQQAVQKPVQHTASINKEDFLKSHSSIHETIKLRLSQNRLHLYFDRIRNEFSTRIE
LLNPEGTEDLFALVKKVMYPAVADTLFGKGLCPTGKGKLEEFAEHFWKFDEGFEYGSQLP
EFLLRDWSQSKQWLLRLFKKIVIEAEMNNPLEETSKTLHQHLLDTLKGNSTYNNSLLLLW
ASQANANPVTFWTLGFIISDPLVYKAAMDEIHSVFGKAGNKELNMNEAELKRLPFIKTCV
LEAIRLRSPGAITRKAVQPLKINNYLVPAGDLLMLSPYWLHRDPTLFPEPEMFR
PERWSKANLEKNVFLEGFVAFGGGKYQCPGRWFALMEMHMLVVMMLYKYEFSLLDPLPKQ
SNLHLVGTQQPDGPCRVRYKLRK*
CYP39A1 Xenopus laevis (African clawed frog)
SwissProt A1A611,
91% to CYP39A1 X. tropicalis
MEQIASVSAQFSPTAALGLLVALLTAVLVRYLLPNASHKPPYPPCIRGWIPWFGAAFEM
GKAPLEFIARAKEKHGPVFTVLAAGNRLTFLNGKEGVSAFFSSKDADFQQAVQKPVQHT
ASINKADFMKSHSSIHETMKLRLSQNRLNLYFDRIRNEFGTRIELLDPEGTEDLFTLVK
QVMYPAVVDTLFGKGLCPTGKDNLKEFAEHFWKFDEGFEYGSQLPEFLLRDWSQSKQWL
LSLFKKIVIEAEMNNPLEETSKTLHQHVLDTLKGIATYNNSLLLLWASQANANPVTFWT
LAFIISDPLVYKTAMDEIYSVFGKTGNSPLNINEAELKRLPFIKNCVLEAIRLRSPGAI
TRKAVQPLKIYNYMIPAGDLLMLSPYWLHRDPVLFPEPEMFRPERWSKANLEKNVFLEG
FVAFGGGKYQCPGRWFALMEMHMLVVMMLYKYEFSLLDPLPKQSNLHLVGTQQPDGPCY
VRYKQRK
CYP39A1 Xenopus laevis (African clawed frog)
SwissProt Q3KQ11 GenEMBL BC106433.1
4 aa diffs to CYP39A1 A1A611 X. laevis
XXXIASVSALFSPTAALGLLVALLTAVLVRYLLPNASHKPPYPPCIRGWIPWFGAAFEMGKA
PLEFIARAKEKHGPVFTVLAAGNRLTFLNGKEGVSAFFSSKDADFQQAVQKPVQHTASI
NKADFMKSHSSIHETMKLRLSQNRLNLYFDRIRNEFGTRIELLDPEGTEDLFTLVKQVM
YPAVVDTLFGKGLCPTGKDNLKEFAEHFWKFDEGFEYGSQLPEFLLRDWSQSKQWLLSL
FKKIVIEAEMNNPLEETSKTLYQHVLDTLKGIATYNNSLLLLWASQANANPVTFWTLAF
IISDPLVYKTAMDEIYSVFGKTGNSPLNINEAELKRLPFIKNCVLEAIRLRSPGAITRK
AVQPLKIYNYIIPAGDLLMLSPYWLHRDPVLFPEPEMFRPERWSKANLEKNVFLEGFVA
FGGGKYQCPGRWFALMEMHMLVVMMLYKYEFSLLDPLPKQSNLHLVGTQQPDGPCRVRY
KQRK
CYP39A1 Danio rerio (zebrafish)
GenEMBL NM_001030189.1
CYP39A1 Salmo salar (Atlantic salmon)
GenEMBL DW563555.1 CB512602.1 ESTs
EVVTLVLSLVILAISAHLLFAGNYPNAPPCIKGWIPWFGVAFEFGKSPLTFISQARDKYGPVFT 193
194 VVAAGKRLTFVTLHEDFRTFFMSKDVDFEQAVQEPVHNTASISKDSFYKFHPACNTLIKG 373
374 RLTPGNVAQLTDHLCEEFNDHLET
1 LGDQGSGGLSELVRAVMYPAVMSNLLGKYNSPGSPFTMEQFKEKFAIYDEGFEYGSQLPD 180
181 MFLREWASSKCWLLSLLGNMVVKAEDDETSSESGNRTLLQHLATLITDKFLPNYGLL 351
352 MLWASLANAIPITFWAVAFILSNPTVYQTAMEQINAALKDQDTRKTKVTAEELQQMPYVK 531
532 WCILEAIRLRAPGAITRRVVRPLRIQNYIIPPGDLLMVSPYWAHRNPHYFPEPEEFKPER 711
712 WEKADLVKN 738
CYP39A1 Oncorhynchus mykiss (trout)
GenEMBL BX298944.3 cDNA
25 LVLFLVVLAISAHLLFGGNYPNAPPCIKGWIPWFGVAFEFGKSPLTFISQARDKYGPVFT 204
205 VVAAGKRLTFVTLHEDFRTFFMSKDVDFEQAVQEPVHNTASISKESFYKFHPACNTLIKG 384
385 RLTPGNVAQLTDHLCEEFNDHLETLGDQGSGGLNELVRAVMYPAVMSNLLGKYNSPGSPF 564
565 TMEQFREKFAIYDEGFEYGSQLPDXVLRXWASSKCWLLSLLGNMXCQAEDDETSSESGNR 744
745 TFTAHLV 765
40A Subfamily
CYP40X rat, mouse, human (name changed to CYP27B1)
Note: This family was created based on the rat sequence AF000139 submitted to
the Nomenclature Committee in May 1997. This was the only sequence available at
the time and it was about 38% identical to rat CYP27. The sequence was
considered a new family and named CYP40. Since then, there have been additional
sequences determined for the rat mouse and human homologs. The rat sequence
AB001992 differs from the AF000139 sequence at 34 amino acids, mostly in two
regions that are probably frameshifts. The sequence AB001992 is 42.3% identical
to the rat CYP27A sequence. The mouse and human sequences are also more than 40%
identical to the CYP27A sequence. Therefore, they belong in the CYP27 family as
a new subfamily CYP27B1. Since there only appears to be one gene in each
species, all three species orthologs will be called CYP27B1. CYP40 has been
retired and this is indicated by the X in CYP40X.
41A Subfamily
CYP41A1 Boophilus microplus (southern cattle tick)
GenEMBL U92732 (414bp)
Crampton,A.L., Miller,C., Baxter,G.D. and Barker,S.C.
Expressed sequenced tags and new genes from the cattle tick,
Boophilus microplus.
Exp. Appl. Acarol. 22 (3), 177-186 (1998)
EST is from the middle of the P450
whole sequence known but still confidential.
CYP41A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C6v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C6v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C8 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C9 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C10 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C11 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C12 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C13 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C14 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41C15 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP41D1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
42A Subfamily
CYP42A1 C. elegans
GenEMBL AL020988 (Y80D3), M89401 (EST cm08B12)
CYP42A1 Caenorhabditis briggsae ortholog
XP_002647751.1 94% to CYP42A1
MGIITASIIVLTITWIIHFAFRKAKFIYDKLTVFQGPAALPLLGNFHQFHFSPEEFFEQSQGIAYMMRKG
DERITRVWLGGLPFVLLYGAEEMEAVLGAPKMLNKPFLYGFLSAWIGDGLLISKPDKWRPRRKLLTPTFH
YDILKDFVEVYNRHGKTLLSKFENQAESGNYEDVFHTITLCTLDVICEAALGTSINAQKDPNSPYLDAVF
KMKDIVFQRLLRPHFFSDTIFKWIGRGEEHDQCVKILHDFTSKAIYARKAKVDAAGGVEQLLAQETAEGR
RRMAFLDLMLDMNSKGELPMEGICEEVDTFTFEGHDTTSAAMNWFLHLMGANPEIQSKVQKEIDEVLGEA
DRPISYEDLGKLKYLEACFKETLRLYPSVPLIARQCVEDIQIRGHTLPSGTAVVMVPSMVHKDPRYWEDP
EIFNPERFISGELKHPYAYIPFSAGSRNCIGMRFAMMEEKCILAILLKNLKVKAKLRTDQMRVAAELIIR
PLFGNELKFERREFGDYKPLID
43A Subfamily
CYP43A1 C. elegans
GenEMBL AF026203
E03E2.1
CYP43A1 Caenorhabditis briggsae ortholog
XP_002644736.1
MCSVVGDKTFSMLRGATPVIVTNDVNLIHAISTESFDCFHSRI
PEALSDDPITAENIHMFAAKGERWKRLRTITSYGLSTVKLKL
LFPTIETCVSEFLDHVNSLSDGQSVVIDHSHS
LFQNHTSYVLARCAYGHKEQNHRVNNFLSVFSDAFGALSDFQKSMTEKIT
YFFPEMKSIFKNNLFAQFLQSTNQQKFLDYLLNLISKFQSRRVIENNNNEESSDPEAGK
YSLLEFFFEHHHEKKIVEKAEGRIDMKKVKVEKSISYQ
EITAQCKFISVAGFDTTANTLTLLFNFLAHNPAIQEQIYNSEIKGNKSSMNFE
TVCSLPILQNCIFETLRLFPHASP
LQMRICTAPITIGQYKFDENMQVVINPWGPHRDRVIWGDDVNCFKPSR
FESLSEQQRKAFMPFGVGPRQCVGMRFALLELKTTAFRMLQKYVVRSTQPVIDRHGKL
VNMTVRDTGTVWPTDKLGLVLTKRDI*
44A Subfamily
CYP44A1 C. elegans
GenEMBL U21321
CELZK177
only mitochodrial-like P450 in C. elegans
MRRSIRNLAENVEKCPYSPTSSPNTPPRTFSEIPGPREIPVIGN
IGYFKYAVKSDAKTIENYNQHLEEMYKKYGKIVKENLGFGRKYVVHIFDPADVQTVLA
ADGKTPFIVPLQETTQKYREMKGMNPGLGNLNGPEWYRLRSSVQHAMMRPQSVQTYLP
FSQIVSNDLVCHVADQQKRFGLVDMQKVAGRWSLESAGQILFEKSLGSLGNRSEWADG
LIELNKKIFQLSAKMRLGLPIFRLFSTPSWRKMVDLEDQFYSEVDRLMDDALDKLKVN
DSDSKDMRFASYLINRKELNRRDVKVILLSMFSDGLSTTAPMLIYNLYNLATHPEALK
EIQKEIKEDPASSKLTFLRACIKETFRMFPIGTEVSRVTQKNLILSGYEVPAGTAVDI
NTNVLMRHEVLFSDSPREFKPQRWLEKSKEVHPFAYLPFGFGPRMCAGRRFAEQDLLT
SLAKLCGNYDIRHRGDPITQIYETLLLPRGDCTFEFKKL
CYP44A1 Caenorhabditis briggsae
XM_001679715.1, XP_002630734.1
85% to CYP44A1 ortholog
MRRSIKILAENLENCPYTSATTTAPPRRFSEIPGPREIPVIGNS
GNLKYAIGTDAETIENYNKHLEEMYNKYGKIVKENLGFGRKYVVHVFDPADAQTVFAA
DGKTPFIVPLQETTQKYREMKGMNPGLGNLNGPEWYRLRSSIQHAMMRPQSVQTYLPF
SQKVSDDLVRHVAEEQIRFGNANMQKVAGRWSLESAGQILFEKSLESLGNRSEWADGL
IELNKKIFQLSAKMRLGLPIFRLFSTPSWRKMVKLEDEFYAEVDRLMDDALDNLKISE
SDSQNMRFASYLINRKELNRRDVKVILLSMFSDGLSTTAPMLIYNLYNIATHPEALRK
IQEEIKEDPTSSKLPYLRACIKETFRMFPIGTEVSRITQKDLTLSGYLIPAGTAVDIN
TNILMRNMVLFSDSPHEFKPERWLEKSKSVHPFAFLPFGFGPMCAGRRFAEQDLLTSL
AKLCANFDIRHRGEPITQIYETLLLPRGNCEFEFKKL
CYP44A1 Caenorhabditis brenneri strain PB2801
ABEG01003567.1
85% to CYP44A1 ortholog
10467 MRRSIKKLAEHVEKCPFNGNPTKSSVTRRFSEIPGPREIPVFGNAGNFKYAIGS (1) 10628
10675 DAKTIESYNIHLEEMYRKYGKIVKENLGFGRKYVVHVFDP (1) 10794
10859 ADAQTVLAADGKTPFIVPLQETTQKYREMKGMNPGLGNL (2) 10975
11023 NGPEWYRLRSSVQHAMMRPQSVQT (2) 11094
11141 YLPFSQKVSDDLISHVAKVQLRFGH 11215
11216 VNMQKVAGRWSLESAGQILFEKSLGSLGDRCEWADSLIELNKKIFQLSAK (2) 11365
11413 MRLGLPIFRLFSTPSWRKMVELEDQFYAEVDRLMDNALDKLKVNDSDNQNMRFASYLIN 11589
11590 RKELNRRDVKVILLSMFSDGLST (0) 11661
11703 TAPMLIYNLYNIAAHPEAQREIRKEIQDDPSSSKLPFLRACIKETFRMFPIGTEVSRITQ 11882
11883 KDLILSGFDVPAGTAVDINTNILMR (2) 11957
12004 DEVLFSDSPRIFKPQRWLEKSKEVHPFAFLPFGFGPRMCAGRRFAEQDLLTSLAK 12168
12169 LCANFEICHRGEPITQIYETLLLPRGNCEFEFRKL* 12276
CYP44A1 Caenorhabditis remanei strain PB4641
AAGD02002953.1
83% to CYP44A1 ortholog
11277 MRKSLQKFAEKCPFSATSVKTSVPRRFSEIPGPLELPIIGNIGNFKYAVRS (1) 11429
11477 DSKTIEGYNHHLEEMYHKYGKIVKENLGFGRKHVIHLFDP (1)
ADAQIVLAADGKTPFIVPLQETTQKYREMKGMNPGLGNL (2) 11761
11802 NGPEWYRLRSSIQHAMMRPQSVQT (2)
YLPFSQIVSEELVKHVAKEQVRFGH 11990
11991 VNMQKVAGRWSLESAGQILFEKSLGSLGDRSEWADGLIELNKKIFQLSAK (2) 12140
12187 MRLGFPLFRLFSTPSWKKMVELEDRFYAEVDRLMDDALDKLTVKDSD ()
12379 SQNMRFASYLINQKELNRRDVKVILLSMFSDGLST (0) 12483
12530 TAPMLIYNLYNIAAHPDAQHKIQKEIKEDPTSTKLPFLRSCIKETFRMFPIGTEVSRITQ 12709
12710 KDLILSGFHVPSGTAVDINTNILMR (2) 12784
12829 NEVLFSDSPHEFKPQRWLEKSKDVHPFTFLPFGFGPRMCAGRRFAEQDLLTSLAK 12993
12994 LCANFDIHHRGEPITQIYETLLLPRGNCEFEFRKL 13098
CYP44A1 Caenorhabditis japonica
chrUn:100501692-100508750
From UCSC browser
MRTSLRKFAENVQKCPFPEKSSDIPARRFSEIPGPREVPFFGSTENLKFAIKS (1)
DAQTIENYNEHLAEMYKNYGKIVKENLGFGRKCVVHLFDP (1)
VDAQTVFAADGKTPFIVPLQETTQKYREMKGMNPGLGNL (2)
NGPEWYRLRSSIQHAMMRPQSVQT (2)
YLPFSQKVSQDLVSHVASEQARFGAVNMQKVAGRWSLESAGQILFEKSL
GSLAENSEWADGLIELNKRIFQLSAK (2)
MRLGLPIFRFFPTPSWRKMVQLEDEFYAEVDRLMDDALDKLKVLDIVEN (2)
SKNLRFASYLINRKELNRRDVKVILLSMFTDGLST (0)
TAPMLIYNLFNIATHPVAQERIRKELEK (1)
DTTKLPFLRACIKETFRMFPIGTEVSRITQKDLVLSGFEIPAGTPVDINTNVLMR (2)
NTVLFADDPLIFKPERWLDKSAATHHPFAFLPFGFGPRMCAGRRFAEQDLLTSLAKLCAKFEIRHVGEPVTQIYETLLLPRGNCKFEFASV*
CYP44A1 Ascaris suum
CB101937.1
44% to CYP44A1 aa 134-170 possible ortholog
NGDEWYRLRSSVQKAMMRPQAVRQYLPAVNRVADELLQFI
CYP44B1 Lottia gigantea (owl limpet)
JGI Protein ID:163695
74% to CYP44B2, 34% to CYP44A1 C. briggsae
35% to CYP44A1 C. remanei
MWGRNVKHAANY
LKRCSISTSLGISRSEGRAVNSNDVSDYNQALPFEDIPGPRG
IKYLGTLHHYMTGRLDKYKYQD
ILEEYFSKYGPIFKETLF
GSTIVHVCDPKMFEVIYQDEGKYPEIEPLVEPSQKFR
GEGDLSLGLGNSNGEKWYNLRAIVQKSML
KPAEVSSHLQIINEIANDFVDKTLHKGYS
DDFLLDTSIWKLESGGALSFGKRPGYLECGSA
QEMEAMKLVKMVDNTFTLATDLKFSFPLYKYIKTPAYKA
LLDSEQYINDVTSVYLSETLKHIETEL
ERTDDFNDIQNTYRFLYSLLGHKN
LSKKDMEVIVLSMFIDGLRTVVPVLISVLFCLSQS
PRVQEKLFTEIYNVLEDRKYIAASDIAQLPYLKACVK
ETFRLYPIGLEISRINQNDMVLGEYKIPSG
TKLNLNNFVLNRD
PNIFANPEAFVPERWLRGSEHAVDA
HPYLLLPFGRGPRMCVGRRFAEQDLYVLISK
LIQNCEPHWTGEKYEHQFKI
LVYPACPVKFQFKPRQSSSK
CYP44B2 Lottia gigantea (owl limpet)
JGI Protein ID:163698
74% to CYP44B1, 37% to 44A1 C. briggsae
MWRNFQKNFFSVCGKVNR
IKRCWISTSLGISRSEGRAVNSNDVSDYNQALPFEDIPGPQG
IKYLGTLPHYMTGRLDKYKYQD
ILEEYFSKYGPIFKETLF
DKTVVHVCHPDMIKVVYQDEGKYPEIEPLMEPTQKSR
CDEGMSLGLGNTNDEQWYRLRSAVQKHMM
RPGEVSNYLPQVNEVANEFVDKTMRKGYS
DDFILDASIWSLESSGYISFGKRLGYMEGGSE
KEAEGVKVVKKNDEAFTLATDLKFSLPFYQQLQTPKYKAWHEAE
NYTTKVASVYFENVLKFLETHL
DSSSEPKKVQNTYRFLYSLLGHKN
LSKKDMEVIVLSMFIDGLRTVVPVLISVLFCLSQS
PRVQEKLFTEIYNVLEDRKYIAASDIAQMPYLKACVK
ETFRLHPNALEISRVTKNNMVLGGYQIPSG
SKLNINAFNMYRN
SDIFENPQNYCPERWLRGWEHAVDV
HPYLLLPFGRGPRMCVGRRFAEQDLYVLISK
FIQNCEPQWRGSEFHQQYKI
LMYPDRPVKFEFKSR
CYP44C1 Capitella capitata (Gallery worm, polychaete worm, annelid)
estExt_Genewise1Plus.C_850046 [Capca1:171547]
39% to CYP44B1, 37% to 44A1 C. briggsae
MATRSLLQQQPSARVKPFSLIPGPRGLPYLGTLLDYKTGKYAPSSFDKAFRANHQKYGKIFKETIAGSTK
VHLCDPDYAQRLFQLEGKRPHTPPLLETSKMYRKINRLSLGLGNMNGEKWSRSRKAVGHLLMKPKSVSQF
LPHINGCVDDFITKIHHLRDEEGLVENFSNEIKMWTLESTANICFETRLGALNGTAAQSDFIQRMVNAMD
SMLEQALKLRFSFGWWRLLPTPAWQKLYDCEDFFFSNAQRIVNEAISKMDALLESGDFVEGHSYPFLSYL
LGREELSLEDVRIISMAMFSDGMITTSPTVASQLYCLATNPEVQDKVYEEVLRVVGIKTKEITSGHLEEL
SYLKSCIKEGFRFFPIGTEISRIVPTDITIGGYLIPKGTHVEVNTNMLLQSPQYFHDAHRFIPERWTRDG
SASNVHPYLVRPFSCGPRMCPGKRIAEQEMLTFIAKLLRHYRVEWRESHEMSQRYRILLAPDCSADFYFI
PRNN*
45A Subfamily
CYP45 Homarus americanus (American lobster)
GenEMBL AF065892 (1581bp)
Snyder,M.J.
Identification of a new cytochrome P450 family, CYP45, from the
lobster, Homarus americanus, and expression following hormone and
xenobiotic exposures
Arch. Biochem. Biophys. (1998) In press
46A Subfamily
CYP46A1 human
GenEMBL NM_006668
Lund EG, Guileyardo JM and Russell DW.
cDNA cloning of cholesterol 24-hydroxylase, a mediator of
cholesterol homeostasis in the brain.
Proc. Natl. Acad. Sci. U.S.A. 96, 7238-7243 (1999)
32% identity with Drosophila 4D2
ESTs H06539, H51951, R36281
mouse homolog EST AA096922
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPS
FLLGHLPCFWKKDEVGGRVLQDVFLDW
AKKYGPVVRVNVFHKTSVIVTSPESVK
KFLMSTKYNKDSKMYRALQTVFGER
LFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAK
AAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAK
FLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILK
AEEGAQDDEGLLDNFVTFFIA
GHETSANHLAFTVMELSRQPEIVAR
LQAEVDEVIGSKRYLDFEDLGRLQYLSQ
VLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL
FSTYVMGRMDTYFEDPLTFNPDRFGPGAPK
PRFTYFPFSLGHRSCIGQQFAQ
MEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
CYP46A4P human = CYP46A-se1[12:13:14]
NT_004424.11|Hs1_4581 chromosome 1 CYP46 pseudogene fragment
Old name = CYP46A4P
2405597 DPLTFNPYRFGPGAPKPRFTYFPFSLGHHSCIGQQFAQMEVKVVMAKLLQRLEFQLVPGP 2405776
2405777 RFGLQ*QATLKPLDPELCTLRPRGWQPAAPPPRC 2405878
CYP46A1 Pan troglodytes (chimp)
XM_003314519 missing the N-term
METFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAF GMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGR DWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAF TVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTF RLLEEETLIDGxxxxxxxxxxFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFP
FSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLR
PRGWQPAPPPPPC
CYP46A1 Macaca fasicularis (cynomolgus monkey)
AB220390 (partial, not assembled correctly)
N-term part (deleted) is not P450 sequence
LQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRL
LEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFS
LGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR
GWQPTPPPPPC
Cyp46a1 mouse
GenEMBL AF094479 NM_010010 ESTs AA096922, R75217
no UNIGENE entry
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLG
HLPYFWKKDEDCGRVLQDVFLDWAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKY
NKDSKMYRALQTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEK
AEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVM
LEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDMPADIL
TQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDE
VVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLL
FSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVV
MAKLLQRIEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
Cyp46a1 rat
CYP46A1 Mesocricetus auratus (hamster)
Genpept ACQ99542
1 LGSAVLLAFG LCCTFVHRAR SRYEHIPGPP RPSFLLGHLP YFWKKDEDCG RVLQDLFLDW
61 AKKYGPVVRV NVFHKTSVIV TSPESVKKFL MSTKYNKDSK MYRAIQTVFG ERLFGQGLVS
121 ECDYGRWYKQ RRVMDLAFSR SSLVSLMETF NEKAEQLVEI LEAKADGQTR VSMQDMLTCA
181 TIDILAKAAF GMETSMLLGA QKPLSQAVKV MLEGISASRN TLAKFMPGKR KKLQEIRESI
241 RLLRQVGKDW VQRRREALKR GEDVPADILT QILKAEEGAQ DDEVLLDNFV TFFIAGHETS
301 ANHLAFTVME LSRQPEIVAR LQAEVDEVVG SKRHLDYEDL GRLQYLSQVL KESLRLYPPA
361 WGTFRLLEEE TLIDGVRVPG NTPLLFSTYV MGRMDTYFED PLTFNPDRFS PGAPKPRFTY
421 FPFSLGHRSC IGQQFAQMEV KVVMAKLLQR LEFRLVPGQR FGLQEQATLK PLDPVLCTLR
481 PRGWQPA
CYP46A1 Bos taurus (cow)
See cattle page for details
MSPGLLMLLGSAVLVVFGLCCTFVHRARSRYEHIPGPPRPS (2)
FLLGHLPYFWKKDEVCGRVLQDVFLDW (2)
AKKYGPVVRVNVFHKTSVIVTSPESVK (0)
KFLMSTKYNKDSKMYHAIQTVFGER (1)
LFGQGLVSECXYERWHKQRRIMDLAFSRSSLVGLMGTFNEKAEQLVEILEAQ 198
199 ADGQTPVSMQDMLTCATMDILAKAAFGMETSMLLGAQKPLSRKVKLILEGISASRNTLAK 378
379 FMPGKWKQLXETRESVRFLRQVGKEWVXRXRXALQRGEDVPADILTQILKAEEGAQD
367 DEILLDNFVTFFIAGHETSANHLAFTVMELSRQPEILARLQAEVDEVIGSKRHLDCEDLG 188
187 RLQYLSQVLKESLR 146
LYPPAWGTFRLLEEETLIDGVRVPGNTPLL
FSTYVMGRMDTYFEDPLTNPDRFGPGAPK
PKFTYFPFSLGPRSCIGQQFAQ
MEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLQPRGWQPAPPPPPC
CYP46A1 pig
BI359892.1, BF193580.1, BF190788.1,
lower case = cow seq.
mspgllmllgsavlvvfglcctfvhrar
SRYEHIPGPPRPSFLLGHLPYFWKK
KDEVCGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKRFLMSTKYNKDS
KMYHAIQTVFGERLFGQGLVSECDYERWHKQRRVMDLAFSRSSLVSLMGIFNEKAEQLVE
ILEAQADGQTPVSMQDMLTCTTMDILAKAAFGIETSMLLGAQKPLSRKVKLIL
egisasrntlakfmpgkwkqlxetresvrflrqv
GKDWVQRRREALQRGEDVPADILTQILKAEEGAQD
DEILLDNFVTFFIAGHETSANHLAFTVMELSRQPEILARLQAEVDEVIGSKRHLDCEDLG
RLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDP
LTFNPDRFSPKAPKPKFTYFPFSLGPRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQSFGLQE
Qatlkpldpvlctlqprgwqpapppppc
CYP46A1 Canis familiaris (dog)
XM_537552.2
94% to CYP46A1 human
MSQVWRSTQDCIHGVSLGFLLGHLPYFWKKDEVCGRVLQDVFLD
WAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYHAIQTVFGERLFGQG
LVSECDYERWHKQRRVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD
MLTCTTMDILAKAAFGMETGMLLGAQKPLSRKVKLILEGITASRNTLAKFMPGKWKQL
REIRESIRFLRQVGKDWVQRRREALKRGEDVPADILTQILKAEEGAQDDEILLDNFVT
FFIAGHETSANHLAFTVMELSRQPEILARLQAEVDEVIGSKRHLDCDDLGRLQYLSQV
LKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD
RFSPKAPKPRFTYFPFSLGPRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRYGLQE
QATLKPLDPVLCTLQPRGWQPAPPPPC
CYP46A1 Xenopus tropicalis (Western clawed frog)
See Xenopus pages for seq
CYP46A1 Danio rerio (zebrafish)
Ensemble protein ID OTTDARP00000024410
cyp46a1-001, transcript ID OTTDART00000029923
Zv8 chr20:4947279-4961019 100% match
Note: This seq. replaces my older version which was a hybrid
1 MIFEWVLYIVFSLLAAVFTAFLGYCLYIHHLHQKYDHIPGPPRDSFLLGHSSSLTKAVYS
61 DNNLIHDLFLYWAEKYGPVYRINTLHYVTIVVYCPEATKTIMMSPKYIKDPFVYKQLFNL
121 FGKRFLGNGLITAVDHDMWYRQRRIMDPAFSSTYLRSLISTFDEMSERLMDKLEEIANNK
181 TPAVMHDLVNCVTLDVICKVAFGVDLNLLNQKDSPFQNAVELCLKGMILDVRDPFFRLFP
241 KNWKLIQQVREATELLRKTGEKWIQNRKTAVKNGEDVPKDILTQILKSAEEENVNNTQDL
301 EQMLDNFVTFFIAGQETTANQLSFAIMALGRNPEIYKRAKAEVDEVLGTKREISNEDLGK
361 LTYLSQVLKETLRLYSTAPGTNRWLHEDIVINGIKVPRGCSVMFSSYVSQRLEKFFKDPL
421 KFDPERFDVNAPKPYYCYYPFSLGPRTCLGQVFAQMEAKLVLAKLLQRFEFSLVPGQSFD
481 IKDNGTLRPKSGVICNIKQCS
CYP46A1 Fugu rubripes (pufferfish)
LKB67200.x1, LGP3798.x1
Scaffold_4537
60% to 46 human
MGVFNLIFGWISQASIFLLLLLFIALLGYCMYIKYTHMKYDHIPGPPRDS (2)
FFSGHSSKLLDIMKDDGVVHDMFLKW (2)
AETYGPVYKIYFLHHVMVFVSCPETTK (0)
EMLMSPKYTKDKFLHNRIGSLFGQR (2)
FLGNGLVTVRDHEKWYKQRRIMDPAFSSL (2)
YLRSLMGNFNETADKLMDKLSEIADNKTTANMLHLVNCVTMEVLAK (0)
VAFGVDLDLLRKSSPFPRAVELCLKGMVFSIRDTFFM (0)
LNPKNWSFIREVRGACRLLRQTGAQWIQQRKTAMRNGEVPKDILTQIIKSAGK (1)
EEIMTQEDEEFMLDNFLTFFIA (1)
GQETTANQLGFCIMELGRHPDILER (2)
VKKEVDEAIGMKQDISYDDLGHLGYLSQ (0)
VLKETLRLYPTAPGTSRDLKEDMVIGGVHVPGGVVCV (0)
FSSYGMGRMETFFKDPLKFDPDRFDPDAPK (2)
PYYCYFPFSLGPRSCLGQNFAQ (0)
MEAKVVMAKLIQRFDFTLLPGQSFDILDNGTLRPKSGVLCSLRHRDHKK*
CYP46A1 Tetraodon nigroviridis (freshwater pufferfish)
84% to fugu CYP46A1
exons 7,8 from CAAE01022534.1
MGICNSIFSWMSQFFIVLLFLLFIALLGYCLYVKYVHLKYDHIPGPPRDS (2)
FLFGHSSTLVEIMKRNGVVHDKFLEW (2)
TEIYGPAYRINLLHYVMVFVACPETTK (0)
EMLMSPKYTKDKFLRDKIANLFGQR (2)
FLGDGLVTIRDHDKWYKQRRIMDPAFSSL (2)
YLRGLMGNFNETAEKLMDKLSEIADNKTTANMLRLVNSVTMEIIak (0)
VAFGVDLDLLRQSSPFPRAVELCLQGMVYNVRDTLFT (0)
LNPKNWSFIKEVREACCLLRKTGAEWIQQRRTAMQNGEVPKDILTQIIKAASK (1)
EEIMTETDEEFMLDNFVTFFIA (1)
GQETTANQLGFCIMELARHPEILKR (2)
ARKEVDEVIGMKQDISYDDLGHLGYLSQ (0)
VLKETLRIYPTAPGTSRDLVEDMVIGGVHVPKGVICI (0)
FSSYTMGRMEKFFKDPLKFDPDRFHPDAPK (2)
PYYCYFPFALGPRSCLGQNFAQ (0)
MEAKVVMAKLIQRFDFTLLP &
GQSFDILDNGTLRPKSGVVCSIRHRSQ*
CYP46A2P Fugu rubripes (pufferfish)
FS:S000256 Scaffold_256
155374 MGVFNLIFGWISQASIFLLLLLFIALLGYCMYIKYTHMKYDHIPGPPRD 155520
155635 SFFSGHSSKLLDIMKDDGVVHDMFLKW 155715
155962 AETYGPVYKINFMHHVMVFVSCPETTK 156042
156393 FSSMEWQMETFFK 156431 frameshift
156431 DPLKFDPDRFDPDAPK 156478
156557 PYYCYFPFSLGPRSCLGQNFAQ 156632
156719 MEAKVVMAKLIQRFDFTLLPGQSFDILDNGALRPKSGVLCSLRHRDHRK 156865
CYP46A2 Danio rerio (zebrafish)
BC055161 cDNA,
N-term in seq gap, Zv8 chr5:73217357-73232610 (-)
MVSEWILYIIFYLLSAVFTAFLAYCLYIHHLHQKYDHIPGPPRDNFLLGHSPSLTKA MYSDDSLIHDLFLQW
AEQYGPVYRINTLHYIAIVVHCPEATK
TILMSPKYAKDPFSYSRLFNLFGKRFLGNGLVTAVDHDIWYRQRRIMDPAFSSSYLRSLI STFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICKVAFGVDLNFLTQKDSPFQ NAIELCLNGMALDARDPLFRIFPKNWKLIQQIRDAAVLLRKTGEKWIQNRKTAVKNGE DVPKDILTQILKIAEEENVNSSEDLEQMMDNFVTFFIAGQETTANQLSFAIMALGRNP EIYKRAKAEVDEVLGTKREISNEDLGKLTYLSQVLKETLRLYPTAPGTNRWLHEDMII NGIKIPGGCSVMFSSFVSQRLEKFFKDPLKFDPERFDENAPKPYYCYYPFALGPRTCL GQVFSQMEAKVVLAKLLQRFEFSLVPGQSFDIKDTGTLRPKSGVICNIKQCS*
CYP46A3P Fugu rubripes (pufferfish)
FS:S000256 Scaffold_256 aa 458-506
148912 MEAKVVMAKLIQRFDFTLLPGQSFDILDTGALRPKSGVLCSLRHRDHKK 149058
CYP46A4 Danio rerio (zebrafish)
93% to CYP46A2
Zv8 chr5:73235997-73241459 (-)
Note: the EST EH438181 covers this sequence and supplies the N-terminal
So the genomic sequence is not correct and this is not a pseudogene
EE322098 was used to correct an internal indel and one other amino acid
MILEWILYIIFYLLSAVFTAFLAYCLYIHYVHQKYDHIP
GPPRDNFLFGHSPSLTKSMYADDSLIHDLFLQWAEKYGPVYRINSLHYIAIVVHCPEATK
TILMSPKYTKDPFVYRRLFNLFGKRFLGYGLITAVDHDIWYRQRRIMDPAFSSS
YLRSLISTFDEMSERLMDKLEEMANNKTPAVMHDLVNCVTLDVICK
VAFGVDLNFLAQKDSPFQNAVELCLNGMTVDLRDPFFR
LFPKNWKLIHQIRDAAELLRKTGEKWIQNRKTAVKNGEDVPKDILTQILKSA
EEENVNNTQDLEQMLDNFVTFFIA
GQETTANQLSFAIMALGRNPEIYKR
AKAEVDEVLGTKREISNEDLGKFTYLSQ
VLKETLRLYPTAPGTNRWLHEDMVINGIKIPGGCSVM
FSSYVSQRLEKFFKDPLKFDPERFDVNAPK
PYYCYFPFALGPRTCLGQVFSQ
MEAKVVLAKLLQRFEFSLVPGQSFDIKDTGTLRPKSGVICNIKQCS*
CYP46A5 Danio rerio (zebrafish)
BC116617 mRNA Danio 08-SEP-2006
100% to EST CN329576.1, 1 aa diff to EST CF996834.1
no exact match in the Zv8 genome assembly
MTSEWLLYMVFYLLSAVFVVFLAYCLYIHQVHQKYDHIPGPPRD
NFLLGHIPTINRVTKSERHMNDLLLIWAEKYGPVYRLNSFHYVIINVHCPEATKTIMM
SPKYLKDPFIYKRLFGLFGKRFLGYGLVTATDHDIWYRQRRIMDPAFSSSYLRGLIST
FNEMSERLMDKLEEMAINKTPAVMHDLVNCVTLDIICKVAFGVDLNLFKQTDNPFQQA
IEQCLQGMVLDLRDPFCKFFP KNWKAIQETKGATVLLRKTGEQWIQNRKTAVEIGEDV
PNDILTQILKTAKEEKVNNTKDHEQMLDNFVTFFIAGQETTANQLSFAIMELGRHPEI
YKRAKAEVDEVLGTKRDISYEDLGKFTYLSQVLKETLRLYPTAPGTNRWLHEDMVING
IKIPGGISVIFSSYVAQRLEKHFKDPLKFDPERFNVNAPKPYYCYYPFSLGPRSCLGQ
VFSQATPAEGALAQLLTQLLTLCSHFLIVLYFSKSSGHASL
CYP46A6 Xenopus tropicalis (Western clawed frog)
NM_001032348.1
53% to human CYP46
note: this frog has five CYP46 genes in two clusters
zebrafish has 2 CYP46 genes
scaffold 519 627623-643634 (+) strand
82% to CYP46A1, 79% to CYP46A7
MGLWALFGWASLLLLALTLICFLLFCGYIQYIHMKYDHIPGPPRD
GFIFGHSPTILRLMKNNKVVYDQYLDWVQ
YGPVVRINALHRVIVLITSPEGVK
EFLMSPKYSKNDIYDRVATLYGM
RFMGKGLVTDKDHDHWYKQRRIMDPAFSR
TYLMDLMGPFNEKAEELMERLSEQADGKSDTEMHNLFSRVTLDVIAK
VAFGMELNSLKDDLTPLPQAISLVMNGI
VETRNPMIKYSLAKRGFIRKVQESIRLLR QTGKECIERRQKQIQDGEEIP
MDILTQILKGAALEEDCDPETLLDNFVTFFIAGQETTANQLSFAVMELGRNPEILQKA
QKEIDEVIGSRRFIEHEDLSKLHYLSQVLKETLRLYPTAPGTSRGLKEEIVIEGVRIP
PNVNVMFNSYIMGRMEQNYTDPLTFNPDRFSPGAPKPYYTYFPFSLGPRSCIGQVFSQ
MEAKVVMAKLLQRYDFELAEGQSFSIFDTGSLRPLDGVICRLRPRTSNTATTNKYIF
CYP46A6 Xenopus laevis (African clawed frog)
EG581889.1
92% to CYP46A6 X. tropicalis (ortholog)
84% to CYP46A8 X. laevis, 84% to CYP46A7 X. laevis
LTHILKAAALEEDCDPETLLDNFVTFFVAGQETTANQLSFAVMELGRNPEILQKAQEEID
EVIGSKRFIEHEDLGKLHYLSQVLKESLRLYPTAPGTSRGVKEEIVIEGVRIPPNSTVMF
NSYIMGRMEQYYTDPLTFNPDRFSPDAPKPYYTYFPFSLGPRSCIGQVFSQMEAKIVMAK
LLQRFDFELAKGQSFRIFDTGSLRPMDGVICRLRPRTKP*
CYP46A7 Xenopus tropicalis (Western clawed frog)
CX981536.1 CX970619.1 CX970620.1 CX370643.2
87% to 46A1 Xenopus tropicalis and 84% to 46A4 Danio
54% to 46A1 human
old scaffold_588:627624-672691
scaffold 519 646604 672690 (+) strand, adjacent to CYP46A6
MGLWAILGWAALLLLALILICFLLYCGYIHYIHMKYDHIPGPPRDR (2)
SFIFGHSTALLKLVNENLLMYDYFLDW (2)
VHKYGPVMRINGLHKVAVLVASPEGIK (0)
EFLMSPKYLKDEFYDFFGSLFGER (2)
LMGKGLLTDRDYDHWHKQRRIMDPAFSRT (2)
YLMGLMGPFNEKAEELMEKLSENSDRKCEVNMHDMFSKVTLDVIGK (0)
VGFGMELNSLNDDQTPFPRAISLVMKGSVEIRNPMIK (0)
YSLAKRGLIRKVQESIRLLRQTGKECIERRQKQIQDGEEIPVDILTQILRGA (1)
ALEKDCDPETLLDNFVTFFIA (1)
GQETTANQLSFAVMSLGRNPEILKK (2)
AQAEIDEVIGSKRDIEYEDLGKLSYLSQ (0)
VLKETLRLYPTAPGTSRTLENEIVIDEVRIPGNVTLM (0)
LNSYVMGRMEQYYKDPLMFNPDRFSPDAPK (2)
PYFTYFPFSLGPRNCIGQVFSQ (0)
MEAKVVMAKFLQRYEFELAEGQSFKILDTGTLRPLDGVICRLRSRTNNKKANK*
CYP46A7 Xenopus laevis (African clawed frog)
86% to CYP46A7 X. tropicalis (ortholog),
80% to CYP46A8
MELWVFIGWAALLLLALAFICFLLYCGYIQYIHMKYDHIPGPPRDSFIFGHSLTLMKVM QENLVIYDYFLDWVQKYGPVMRINGFHRVAVLVASPEGVQEFLMSPKYSKDNFYDFFGT LFGVRFMGKGLLTDRDYDHWHKQRRIMDPAFSKAYLMGLMDPFNEKAEVLMERLSEKSD TKCEVNMLDMFCKVTLDVIGKVGFGIELNSLKDDQTPFPQAISLVMKGTVEIRNPMLKF SLGKRGFIREVQSSVRLLRQTGKECIERRQKQIQDGEEIPKDILTQILKGAALEKDCDP ETLLDNFVTFFVAGQETTANQLSFAVMSLGRNPETLKKAQAEIDEVIGSKRDIEYEDLS KLKYLSQVLKETLRLYPTAPGTSRALEKEIVIEGVRIPPNVTVTLNSYVMGRMEQFYED PLTFNPDRFSPDAPKPYFTYFPFSLGPRNCIGQVFSQMEAKVVLAKFLQRYDFELANGQ SFKILDTGTLRPLDGVICRLRSRTSKKEAHM
CYP46A8 Xenopus tropicalis (Western clawed frog)
NM_001032346
54% to human CYP46A1, 82% to CYP46A6 X. laevis
note: this frog has five CYP46 genes
scaffold 519 676371-696647 (+) strand
adjacent to CYP46A7
MGLWALIGWAALLLLALILICFLLFSGYIHYIHMKYDHIPGPPR
DSFFLGHSPTMLRLMKNNLLMYDHFLGWVQKYGPVVRINGLHRVIILVVSPEAVKELL
MSPKYSKDKFYDVIANMFGVRFMGKGLVTDRDYDHWHKQRRIMDPAFSRTYLMGLMGP
FNEKAEELMEKLMEKADGKCEIKMHDMLSRLTLDVIGKVAFGMELNSLNDDLTPFPKA
ISLVMKGIVEMRNPMVRYSLAKRGFIRKVQESIRLLRQTGKECIERRQKQIQDGEEIP
VDILTQILKGAAMEEECDPEILLDNFVTFFIAGQETTANQLSFVVMELGRNPEILEKA
QAEIDEVIGSKRDIEYEDLGKLQYLSQVLKETLRLYPTAPGTSRGLTEDMVIDGVKVP
ENVTIMLNSYIMGRMEQYYSDPLTFNPDRFSPDAPKPYYSYFPFSLGPRSCIGQVFSQ
MEAKVVMAKLLQRYEFELAEGQSFKILDTGTLRPLDGVICRLRPRTSKKAATLQ
CYP46A8 Xenopus laevis (African clawed frog)
BC153799
92% to CYP46A8 X. tropicalis (ortholog),
81% to CYP46A5, 79% to CYP46A.1
MGLWILIGWATLLLLALALICFLLYCGYIQYIHMKYDHIPGPPRDSFLFGHSPTMLRLM KNNLLMYDHFLELVQKYGPVIRINGLHRAIILVVSPEAVKELLMSPKYTKDRFYDVIAN MFGVRFMGNGLVTDRDYDHWHKQRRIMDPAFSRTYLMGLMGPFNEKAEELMERLMEKAD GKCETKMHDMLSRLTLDVIGKVAFGMELNSLNDDRTPFPRAISLVMKGIVEMRNPMVRY SLAKRGFIRQVQESIRLLRQTGKECIERRQKQIQDGEEIPKDVLTQILKGAALEEECDP EILLDNFVTFFIAGQETTANQLSFAVMELGRNPEILEKAQAEIDEVIGSKRDIEYEDLG KLQYLSQVLKESLRLYPTAPGTSRWLKEDMIIDGIKIPANVTMMLNSYIMGRMEEFHTD PLTFNPDRFSPDAPKPYYSYFPFSLGPRSCIGQVFSQMEAKVVMAKLLQRYEFEVAEEQ SFKILDTGTLRPLDGVICRLRPRTSNKAAAPK
CYP46A8 Xenopus laevis (African clawed frog)
BG018841 dab13d08.y1 opposite end to BG022212 dab13d08.x1
45% to CYP46 N-term 1-200
MGLWTLIGWATLLLLALALICFLLYCGYIQYIHMKYDHIPGPPRDSFLLGHSPTMLRLMKNNLLMYDHFL 254
255 ELVQKYGPVIRINGLHRAIILVVSPEAVKELLMSPKYTKDRFYDVIANMFGVRFMGNGL 431
432 VTDRDYDHCHIQRRIMDPAFSRTYLMGLMGPFNEKAEELMERLMEKADGKCETKMHDMLS 611
612 RLTLDVIAR 638
74% to CYP46 391-498
515 LQLNSYIMGRMEEFHTDPLTFNPDRFSXDAPKPYYSYFPFSLGPRSCIGQVFSQMEAKVVMAKLL 321
320 QRYEFELAEEQSFKILDTGTLRPLDGVICRLRPGTSNKAAAPK* 189
CYP46A9 Xenopus tropicalis (Western clawed frog)
scaffold_49:1707219-1730127 (+) strand
First part matches
scaffold_49:1707219-1723435 with 7 aa diffs
Then new seq is found below this up to 1730127
58% to CYP46A8, 56% to CYP46A6, 56% to CYP46A7
MWHSVIVHCLSWVYSGFLLIIIGAVVAFLAYCAYIKYMHLKYDDIPGPPRDS (2)
FLLGHIPTLSKAEENYSVVHDLFLHW (2)
AEIYGPVFKINILHRVMIYSTSPESVK (0)
ECLMSSKYPKDPYTYNQLFNLFGKR (2)
FLGKGLLTDPDHDHWYHQRRIMDPAFSNT (2)
YLKEMIGIFNERAEQMMEKLEEKADSHQEVSMHSIINRVTLDVITK (0)
VAFGMDLGLVEGNKTDFPNAISKVLTGMMRYIQNPYMQ (0)
YFPKHWAFVREVQESADLLRKTGKECISQRKKAMQNGEELPKDILTKILQCA (1)
ELENALDDEIMLDNFITFFIA (1)
GQETTANQLSFTVMELTRQPEIMTK (2)
LRMEVDEVIGFKRDISYDDIQNLNYMTQ (0)
VLKESLRFYPPGPGTSRYLKEDTIFEGIKIPGGVSIT (0)
FNTYVMGRMEKFFQDPCKFDPERFHPAAVK (2)
PYFCYFPFALGPRSCLGQIFSQ (0)
LEAKVILSKLIQRFEFELVPGQSFGIKDTGTLRPRDGVVCTLKSRA*
CYP46A10 Xenopus tropicalis (Western clawed frog)
scaffold_49:1780107-1800536 (+) strand
Downstream of CYP46A9
97% to CYP46A9 scaffold_49:1707219-1730127 (+) strand
EL729253.1 fills in missing exon 8
MWHSVIVHCLSWVYSGFLLIIIGAVVAFLAYCAYIKYMHLKYDDIPGPPRDS (2)
FLLGHIPTLSKAEENYSVVHDLFLHW (2)
AEIYGPVFKVNILHRVMIFSTSPESVK (0)
ECLMSSKYPKDPYTYNQLFNLFGKR (2)
FLGKGLLTDPDHDHWYHQRRIMDPAFSNT (2)
YLKEMIGIFNERAEQMMEKLEEKADSHQEVSMHSIINRVTLDVITK (0)
VAFGMDLGLVEGNKTNFPNAISKVLTGMMQYIRNPYMQ (0)
YFPQHWAFVREVQESADLLRKTGKECISQRKKAMQNGEELPKDILTKILQCA
ELENALDDEIMLDNFITFFIA (1)
GQETTANQLSFTVMELTRQPEIITK (2)
LRMEVDEVIGFKRDISYDDIQNLNYMTQ (0)
VLKESLRFYPPGPGTSRYIKEDTIFEGIKIPGGVPIT (0)
FNTYVMGRMEKFFQDPFKFDPERFHPAAVK ()
PYFCYFPFALGPRSCLGQIFSQ (0)
LEAKVILSKLIQRFEFELVPGQSFQIKDTGTLRPRDGVVCTLKSRA*
CYP46A10 Xenopus tropicalis (Western clawed frog)
SwissProt B1H1A6 58% TO CYP46A1
4 aa diffs to 46A10 Xenopus tropicalis
MWHSVIVHCLSWVYSGFLLIIIGAVVAFLAYCAYIKYMHLKYDDIPGPPRDSFLLGHIP
TLSKAEENYSVVHDLFLHWAEIYGPVFKVNILHRVMIFSTSPESVKECLMSSKYPKDPY
TYNQLFNLFGKRFLGKGLLTDPDHDHWYHQRRIMDPAFSNTYLKEMIGIFNERAEQMME
KLEEKADSHQEVSMHSIINRVTLDVITKVAFGMDLGLVEGNKTNFPSAISKVLTGMMQY
IRNPYMQYFPQHWAFVREVQESADLLRKTGKECISQRKKAMQNGEELPKDILTKILQCA
ELENALDDEIMLDNFITFFIAGQETTANQLSFTVMELTRQPEIITKLRMEVDEVIGFKR
DISYDDIQNLNYMTQVLKESLRFYPPGPGTSRYIKEDTIFEGIKIPGGVPITFNTYVMG
RMEKFFQDPFKFDPERFHPAAVKPYFCYFPFALGPRSCLGQIFSQLEAKVILSKLIQRF
EFELVPGQSFEIKDTGTLRPRDGVVCTLKSRA
CYP46a-de1b2b3b4b5b Danio rerio (zebrafish)
chr20:4973129-4977542 (+)
note: this sequence and CYP46A4P would make a complete gene
but they are on different chromosomes
MISEWIFYIILYLLAAVFTAFFAYCLYVHHIHQKYDHIPGPPRD
NFLLGHSPSLTKALYSDDSLIYDLFLQW
AEKYGPVYRINTLHYVTIVVYCPEATK
TIMMSPKYTKDPFVYRRVFNLFGKR
FLGYGLITAVDHDIWYRQRRIMDPAFSSS
46A-se1[12:13:14] human = CYP46A4P
NT_004424.11|Hs1_4581 chromosome 1 CYP46 pseudogene fragment
Old name = CYP46A4P
2405597 DPLTFNPYRFGPGAPKPRFTYFPFSLGHHSCIGQQFAQMEVKVVMAKLLQRLEFQLVPGP 2405776
2405777 RFGLQ*QATLKPLDPELCTLRPRGWQPAAPPPRC 2405878
CYP46-se2[14:15] Danio rerio (zebrafish)
exons 14,15
Zv8 chr5:73126154-73127267 (+)
PYYTYYPFALGPRTCIGQVFSQ
MEAKVVLAKLLQRFEFSLVPGQSFDIKDTGTLRPKSGVICNIKQCS*
CYP46-se3[1:2:3:4] Danio rerio (zebrafish)
Zv8 chr7:11430449-11434822
CYP46 solo exons 1-4
MISEWLLYMLFYLLSAVFVVFLAYCLYIHQVHLKYDHIPGPPRD
FLLGHIPTINRVTKSERHMNDLLLIW
AEKYGPVYRLNSFHYVIINVHCPEATK
TIMMSPKYLKDPFIYKRLFGLFGKR
Cyp47a1x Drosophila melanogaster
GenEMBL AC005556, AC004516, AC004426 intron exon boundaries
approximate
renamed Cyp4aa1 following CYP4Z1
CYP48A1 Trichogramma cacœciae (a parasitoid wasp)
GenEMBL AF207950
BBRC 268, 677-682 (2000) Cloning and expression of cytochrome
P450 genes belonging to the CYP4 family and to a novel
family, CYP48, in two hymenopteran insects, Trichogramma
cacœciae and Apis mellifera by S. Tares, J.B. Bergé and M. Amichot.
123 amino acid sequence from I-helix to PERF region
45% identical to CYP47A1, but sure to drop into the
mid to low 30% range for a full length sequence
clone name 16Tc
66% to CYP4AB22
TAAAMTFTIMLLAENEEAQDKARAEVTQIFDRCDGKIEMQDIQD
MTYLEWCVKEALRLYPPVSTMTRTMSEDLQLSKDFLVPAGAEVIFHLYDTHRDPNFWE
DPDKFDPDRFSPERSHGRHPFSYL
CYP48A2v1 Trichogramma cacœciae (a parasitoid wasp)
GenEMBL AF207951
BBRC 268, 677-682 (2000) Cloning and expression of cytochrome
P450 genes belonging to the CYP4 family and to a novel
family, CYP48, in two hymenopteran insects, Trichogramma
cacœciae and Apis mellifera by S. Tares, J.B. Bergé and M. Amichot.
124 amino acid sequence from I-helix to PERF region
40% identical to CYP47A1, but sure to drop into the
mid to low 30% range for a full length sequence
clone name 15Tc
72% to CYP4AB10
TGMAMTFTLMLLAENKEAQTKARAEVTQVMEKYNGNLNTSSLQE
LPYLERCIKESLRLFPPVATLLRYTADELQLKNALVPADSHIMIHLYDTHRDANYWPN
PDVFDPDRFLPERSANRHTFAYV
CYP48A2v2 Trichogramma cacœciae (a parasitoid wasp)
GenEMBL AF207952
BBRC 268, 677-682 (2000) Cloning and expression of cytochrome
P450 genes belonging to the CYP4 family and to a novel
family, CYP48, in two hymenopteran insects, Trichogramma
cacœciae and Apis mellifera by S. Tares, J.B. Bergé and M. Amichot.
124 amino acid sequence from I-helix to PERF region
40% identical to CYP47A1, but sure to drop into the
mid to low 30% range for a full length sequence.
58% identical to CYP48A1
clone name 21Tc ony two amino acid differences with CYP48A2v1
71% to CYP4AB10
TGMAMTFTLMLLAENKEAQTKARAEVTQVMEKYNGNLNTSSLQE
LPYLERCIKESLRLFPPVATFLRYTADVLQLKNALVPADSHIMIHLYDTHRDANYWPN
PDVFDPDRFLPERSANRHTFAYV
CYP49A1 Drosophila melanogaster
GenEMBL AC017930 48452-54739 AC007398 AC007418
ESTs AA941795 AI258819 AA697999
mitochondrial P450 fits in the mitochondrial clan
Cyp49a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP49A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2l1
CYP49A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.423a
45% to 49A1 Drosophila. Note this sequence is
named in the same subfamily as other CYP49s since
there seems to be only one orthologous sequence per
species and it does not make sense to name orthologs with
different subfamily names.
CYP49A1X Bombyx mori (silkworm)
BAAB01133495.1 BAAB01150577.1 BAAB01091102.1 BAAB01198981.1
BAAB01133297.1 BAAB01093561.1
44% to CYP301A1
CYP49 and CYP301 are nearly subfamilies of a single family
Note: name changed based on Rene Feyereisens analysis
Name changed to CYP301B1
See silkworm page for sequence
CYP49A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
77% to CYP49A1 Bombyx mori
CYP49A1 Plutella xylostella
Gene number CCG012658.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
78% to CYP49A1 Bombyx mori
CYP49A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970738
63% to 49A1 Drosophila, 47% to CYP301A1 Tribolium
MSLSRKLLVPKRALAVAQRAYSTDRPYSTAIMPELLDELAIPEHVERVEATPRPYSAIPGPKELPLIGNA
WRFAPIIGQYKIQELDKVMWSLNRDYGRIVKVGGLIGHPDLLFVFNGDDIEKVFRMEEAMPHRPSMPSLH
YYKQILKKDFFDGNAGVIGVHGPKWEEFRKKVQHALLPPQIAKKYIEPLDVIAGDFLHRMEDMLDENQEL
PNHFLSEIYKWALESVARVSLDTRLGCLEPNLSQNSESQRIINSINTFFWNVAEVELKMPVWRVYKNRSF
KKYIGALEDFRTLCLKHIHKSMEKMQEKNFDEIKEENISIVERILLKTDNPKLAAVLALDLLLVGVDTTS
IAAASTIYQLSQNPEKQQKLFDELQQVLPENDSKIDVSIQDKMPYLKACIKETLRMYPVIIGNGRSLQTD
TVIAGYKVPKGTHVIFPHLVVSNSEDYFHEPHRFLPERWLKTENACPMHKKIHPFVTLPFGYGRRSCLGR
RFAEAELQILLAKIFRKYKVEYNYGPLSYKITPTYVPEQPLKFKLVKRE
CYP49A1 part 1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 15
84% to CYP49A1 Tribolium castaneum
EXXR fragment
CYP49A1 part 2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 13
89% to CYP49A1 Dendroctonus ponderosae
C-term fragment
CYP49A1 Aedes aegypti (yellow fever mosquito)
CYP49A1 Culex pipiens
CYP49A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph49, 58% to CYP49A1 Aedes, only 44% to CYP303A1 Aedes,
58% to 49A1 Anopheles gambiae
Pediculus genome site
CYP49A1X Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
65% to CYP301B1 Acyrthosiphon pisum, C-term only
name changed to CYP301B1
CYP49A1? Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_262 only 26% to CYP49A1 unidentified mito clan N-term
All best hits are CYP49A1 and this protein is not well conserved
CYP49A1 Bombyx mori (silkworm)
BAAB01014940.1 BAAB01083735.1 BAAB01056249.1
51% to CYP49A1 Drosoph.
CYP49 and CYP301 are nearly subfamilies of a single family
Note name changed based on Rene Feyereisens analysis
Formerly CYP49A2
See silkworm page for sequence
CYP49A1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
76% to CYP49A1 Tribolium castaneum
clone name DPO024_I03
CYP49A2X Bombyx mori (silkworm)
BAAB01014940.1 BAAB01083735.1 BAAB01056249.1
51% to CYP49A1 Drosoph.
CYP49 and CYP301 are nearly subfamilies of a single family
Note name changed based on Rene Feyereisens analysis
Name changed to CYP49A1
See silkworm page for sequence
Note this is the last two digit number for animal P450s (except CYP51). The
animal P450s will continue at CYP301A1. This leaves 200 possible animal
families before reaching CYP501 and higher that are reserved for lower
eukayotes.
51A Subfamily
A note on nomenclature. CYP51s were originally all called CYP51, because only one
gene was found per species and they all seemed to be in this one conserved family.
However, rice had many CYP51s in at least two sequence groups, so subfamilies
have been designated for CYP51s. These are not the typical subfamilies, but only
one subfamily is created for each major taxonomic group. CYP51A for animals,
CYP51B for bacteria. CYP51C for Chromista, CYP51D for Dictyostelium, CYP51E
for Euglenozoa, CYP51F for fungi. Those groups with only one CYP51 per species
are all called by one name: CYP51A1 is for all animal CYP51s since they are
orthologous. The same is true for CYP51B, C, D, E and F. CYP51G (green plants)
and CYP51Hs (monocots only so far) have individual sequence numbers.
CYP51A1 human
GenEMBL U23942 (3172bp)
Stromstedt,M., Rozman,D. and Waterman,M.R.(1995)
The ubiquitously expressed human CYP51 encodes lanosterol 14 alpha
demethylase, a cyochrome P450 whose expression is regulated by
oxysterols.
Arch. Biochem. Biophys. 329, 73-81 (1996)
unpublished
CYP51A1 human
GenEMBL U51684 to U51692 (genomic sequence)
Rozman,D., Stromstedt,M., Tsui,L.-C., Scherer,S.W. and
Waterman,M.R.
Structure and mapping of the human lanosterol 14-alpha demethylase
gene (CYP51) encoding the cytochrome P450 involved in cholesterol
biosynthesis; comparison of exon/intron organization with other
mammalian and fungal CYP genes.
Genomics (1996) In press
CYP51A1 human
GenEMBL D55653 (3085bp)
Aoyama,Y., Funae,Y, Noshiro,M., Horiuchi,T. and Yoshida,Y.
Occurrence of a P450 showing high homology to yeast lanosterol 14-
demethylase (P450DM) in rat liver.
Biochem. Biophys. Res. Commun. 201, 1320-1326 (1994)
CYP51A1 Pan troglodytes (chimpanzee)
XM_003318576 REVISED N-TERM
lanosterol 14-alpha demethylase
99% (3 aa diffs) to human
MEKVTGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQLPAGV
KSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFT
MVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGV AYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFQSWGESGEKNVFEALSEL IILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHRE IKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSS TTSAWMGFFLARDKTLQEKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRP PIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPAS GEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTP
ENPVIRYKRRSK
CYP51A1 Macaca fasicularis (cynomolgus monkey)
DQ074804
Yasuhiro Uno
Submitted to nomenclature committee 1/11/2005
Clone name mfCYP51A1_7H11
98% to CYP51 human
MAAAAGMMLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTL
SLVYLFRLAAGHLVQLPAGAKSPPYIFSPIPFLGHAIAFGKSPVEFLENAYEKYGPVF
SFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLE
QKKMLKSGLNIAHFKQHVSIIEKETKEYFQSWGESGEKNVFEALSELIILTASHCLHG
KEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQK
RRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLA
RDKTLQEKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMART
PQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGA
GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
CYP51A1 Bos taurus (cow)
See cattle page for details
22188 MLDLLQAGGSVLGQAMEQVTGGNLASMLLIACAFTLSLVYLFRLAVGHLAPPLPTGA (0) 22018
20194 KSPPYIVSPIPFLGHAIAFGKSPIEFLEDAYEK (0) 20096
17795 YGPVFSFTMVGKTFTYLLGSEAAALLFNSKNEDLNAEEVYSRLTTPVFGKGVAYDVPNT 17619
16395 VFLEQKKMLKSGLNIAHFRQHVSIIEKETKEYFKSWGESGEK 16270
14644 NLFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFR 14468
13586 RRDRAHREIKNIFYKAIQKRRESGEKIDDILQTLLESTYK 13467
13076 DGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQEKCFLEQKTVCGENLPPLTYDQ (0) 12882
11489 LKDLNLLDRCIKETLRLRPPIMTMMRLAKTP 11397
10597 QTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLEDSPASGEKFAYVPFGA (1?) 10427
7020 GRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPEKPIIRYKRRSK* 6841
CYP51A1 pig
AB042982, AB009988, NM_214432
MVLLGLLQAGGSVLGQAMEQVTGVNLLSSLLLACAFTLILVYLF
RQAIGHLAPLPAGAKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG
KTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLK
SGLNIAHFRQHVSIIEKETKEYFQSWGESGERNLFEALSELIILTASHCLHGKEIRSQ
LNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRQSEE
KIDDILQTLLDSTYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ
EKCYLEQKTVCGEDLPPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAG
YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCI
GENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
CYP51A1 Canis familiaris (dog)
XM_532457.2
MLLLGLLQAGGSVLGQAMERVTGGNLLSMLLIACAFTLGLVYLI
RLAVGHLAPLPAGAKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVG
KTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLK
SGLNIAHFRQHVSIIEKETKEYFQSWGESGEKNLFEALSELIILTASHCLHGKEIRSQ
LNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKNIFYKAIQKRRQSEE
KIDDILQTLLDSTYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQ
DKCYLEQKTVCGEDLPPLTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTIAG
YTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCI
GENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
CYP51P1 human
no accession number
Rozman, D. Stromstedt, M. and Waterman, M.R. The three human
cytochrome P450 lanosterol 14a-demethylase (CYP51) genes reside on
chromosomes 3, 7, and 13: Structure of two retrotransposed
pseudogenes,
association with a line-1 element, and evolution of the human CYP51
family.
Archives of Biochemistry and Biophysics 333, 466-474 (1996).
processed pseudogene on chromosome 3
CYP51P1 human
processed pseudogene U36926 5 in frame stops
MAAAAGMMLLGLLQAGG*VLGQAMEEVAGGNLLSMLLIACAFTLSLVYLFRLAAGHLVQL
TAGAKSPPYIFSPVPFLGHAIAFGKSPTEFLENAYGNYGPVFSFIMVGKAFTYLLGSDAA
ALLFNSKNEVLNAEDVYSRLTTPVFG*GVAYDVPNPVFLEQKKTLKSGLNIAHFK*HVSI
IEKETKEYFESWGESGEKNVFAALSELIILTASHYLHGKEIRSQHNEKVAQLYADLDGGF
SHAAWLLPGWLPLPCFRRRDRAHQEIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGR
PLTDDEVAGMLTGLLLAEQHTSSTSA*MGFFLARDKTLQEKCYLEQKTVCGENLPPLTY
DQLKDLNLLDRCIKETLRLRHPVMIMMRMARIPKTVAGYTIPPGHQVCVSPTVNQRLKDS
WVEHLDFNPDRYL*DNPASREKFAYVPFGAGHHGCTGENFAYVQIKTIWSTMLRLYEFDL
IDGYFPTVNYTTMIHTPENPVIHYK*RSK
CYP51P2 human
no accession number
Rozman, D. Stromstedt, M. and Waterman, M.R. The three human
cytochrome P450 lanosterol 14a-demethylase (CYP51) genes reside on
chromosomes 3, 7, and 13: Structure of two retrotransposed
pseudogenes,
association with a line-1 element, and evolution of the human CYP51
family.
Archives of Biochemistry and Biophysics, 333: 466-474 (1996)
processed pseudogene on chromosome 13
CYP51P2 human
processed pseudogene U40053
MAAAAGMMLLGLLQAG
GSVLGQAMEEVTGGNLLSMLLIACTFTLSLVYLFRLAAGHLVQLPAGAKSPPYVFSPVP
FPGHAIAFGKSPVEFLE
NAYEKYGPVFSFTMVGKTFTYL
LGSDAAALLFNSKNEDQNAEDVYSHLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNKAHF
KQHVSL
EKETKEYFQSWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFS
HAAWLLPGWLPLPSFRCRDRAHWEIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRP
LTDDEVAGMLIGLLLAGQHSSSTTSAWMDFFLARDKTLQEKCYLEQKTVCGENLPPLTYD
QLKGLNLLDRCIKETLRLRPPIMIMMRMARTPQTVVGYTIPPGHQVCVSPTVNQRPKDSW
VERLDFNPDCYLQDNPASGEKFAYVPFGAGCHR*IGENFAYVQIKTIWSTMLRLYEFDLI
DGYFPIVNYTTMIHTPENPLIHYKRRSK
CYP51P3 human
NT_025741.8|Hs6_25897 chromosome 6 CYP51P3
In an intron of the SASH1 gene
20447678 MLGLVQMSRSALGQLVEWVAGESDSLLSMLLISCAFILSLVCFATIVTTWPSCQLVQNAH 20447857
20447858 HMFSLPLHSLGMPYIWEKLN*ISRKCI*EVWAYEKYGPVCSFSVVSKTFT 20448007
20447859 ICFLSHYIPWACHTFGKS*IEFLESAYEKYGHMRSMDLYVVFLW*ARHLLLERDETAL 20448032
20448347 LFNSKTKDAEDVYSHLRTPAFGKGVECDMPNPAFLGQEKMLKSSLKVAHFRQQVSI 20448514
20448515 TEKERNTFKLGRKQRKKLCEALSELII 20448595
FDS*PWFTWKGNQKSTQ*EVAQLCADVSGGFKPLA 20448698
20448699 WLRPRWLPLRGCRSSYKAH*EHNYCL*GNPETQKPEEKIQGILQTLLDTTDKGEHLLAD 20448875
20448876 EEVTGLLIRLFSGQHTSSTTGA*MSCFVARDETLHEKCYLKQKTVRGEDLPSLTYDLLK 20449052
20449426 VIGRTIPAGHQMGLSLTVNQGFQDTWVELVDPDQ*LQDISTGEK 20449557
20449566 GGGRHHIGKNFAHVQIKTVWSTLFHLYEFDFIDGYFPTVNYKTVVHHTPKNPVITYK*R 20449742
CYP51P3 Cavia porcellus (Guinea pig)
cavPor3_dna scaffold_60:1743956-1873082 at UCSC browser
32% to 51 human in orthologous position to CYP51P3 pseudogene
inside SASH1 gene
60284 VVAEVGWLLLGFWQVSRLVVRWVVEQVTGASPCPY*PSPGPLSWAGLSASHL* 60126
60125 SPGTAAGGTESPSYLSLCSIPWAH*GCALAFW*CPAEFLENRV*EEWACLEFLWGEEEIY 59946
59945 FLVESDAAALLFKSKTEELNEEVHS 59871 CVPASGFQEG 59841
59545 VFIVETETKE*SNVGEEVEKIMYMSNFHSQS*F*KEIRSPSMWPWCSSYGA 59393
59392 IWSC*PFT
59368 WLLLGWQPWPRFSAATELTEASRTLSVRPSQSADTHEI*KKSSDSLHPLLKSTDKTGCPV 59189
59188 ACDEEAGMLT*LSFSR*LTSMTGF*MELIVARQNASRKRDL*QETVCRKALLPVTCDQL 59012
59011 RALNLLAHCIRQTSRPQ*DSSDCGKVSLFFQDSDYVFQPTGLES*WMH 58868
58867 ALKSLGDKFAHMPFRARHHCTGE 58799
58799 NFAYVQTRTV*FATLHWCGFDLINRFFPTINYTTMIRIPENLV 58671
CYP51A1 rat
GenEMBL D29962 (1924bp) PIR JC2334 (430 amino acids)
GenEMBL D55681 (2268bp)
Aoyama,Y., Funae,Y, Noshiro,M., Horiuchi,T. and Yoshida,Y.
Occurrence of a P450 showing high homology to yeast lanosterol 14-
demethylase (P450DM) in rat liver.
Biochem. Biophys. Res. Commun. 201, 1320-1326 (1994)
Note: This is the first time a single P450 family is represented in
plants and animals. The N-terminal is more conserved than the C-
terminal.
CYP51A1 rat
GenEMBL U17697 (2383bp)
Sloane,D.L., So,O., Leung,R., Scarafia,L.E., Saldou,N., Jarnagin,K.
and Swinney,D.C.
Molecular Cloning and Functional Expression of Rat Lanosterol
14 alpha-Demethylase
Gene (1995) In press
CYP51A1 rat
Aoyama, Y. et al . Sterol 14-demethylase P450 (P45014DM) is one of
the most ancient and conseved P450 species.
The Journal of Biochemistry 119: 926-933 (1996)
includes a report on a processed pseudogene from CYP51 in rats
Cyp51 mouse
GenEMBL NM_020010 AF166266 Mm.24155
MEQVTGGNLLSTLLIACAFTLSLVYLFRLAVGHMVQLPAGAKSP
PHIYSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSLTMVGKTFTYLLGSDAAALLFN
SKNEDLNAEEVYGRLTTPVFGKGVAYDVPNAIFLEQKKIIKSGLNIAHFKQYVPIIEK
EAKEYFQSWGESGERNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFT
HAAWLLPAWLPLPSFRRRDRAHREIKNIFYKAIQKRRLSKEPAEDILQTLLDSTYKDG
RPLTDEEISGMLIGLLLAGQHTSSTTSAWMGFFLAKDKPLQEKCYLEQKAVCGEDLPP
LTYDQLKDLNLLDRCIKETLRLRPPIMTMMRMAKTPQTVAGYTIPPGHQVCVSPTVNQ
RLKDSWAERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCVGENFAYVQIKTIWSTML
RLYEFDLINGYFPTVNYTTMIHTPENPVIRYKRRSK
CYP51P3 Cavia porcellus (Guinea pig)
cavPor3_dna scaffold_60:1743956-1873082 at UCSC browser
32% to 51 human in orthologous position to CYP51P3 pseudogene
inside SASH1 gene
60284 VVAEVGWLLLGFWQVSRLVVRWVVEQVTGASPCPY*PSPGPLSWAGLSASHL* 60126
60125 SPGTAAGGTESPSYLSLCSIPWAH*GCALAFW*CPAEFLENRV*EEWACLEFLWGEEEIY 59946
59945 FLVESDAAALLFKSKTEELNEEVHS 59871 CVPASGFQEG 59841
59545 VFIVETETKE*SNVGEEVEKIMYMSNFHSQS*F*KEIRSPSMWPWCSSYGA 59393
59392 IWSC*PFT
59368 WLLLGWQPWPRFSAATELTEASRTLSVRPSQSADTHEI*KKSSDSLHPLLKSTDKTGCPV 59189
59188 ACDEEAGMLT*LSFSR*LTSMTGF*MELIVARQNASRKRDL*QETVCRKALLPVTCDQL 59012
59011 RALNLLAHCIRQTSRPQ*DSSDCGKVSLFFQDSDYVFQPTGLES*WMH 58868
58867 ALKSLGDKFAHMPFRARHHCTGE 58799
58799 NFAYVQTRTV*FATLHWCGFDLINRFFPTINYTTMIRIPENLV 58671
CYP51A1 Gallus gallus (chicken)
DKFZ426_22O10R1 from http://www.ri.bbsrc.ac.uk/cgi-bin/est-blast/blast.pl
Roslin Institute chicken EST project
603372085F1>603372085F1 cloneID='ChEST280i22' Chondrocytes from http://www.chick.umist.ac.uk/
603582971F1>603582971F1 cloneID='ChEST534n18' stage_36_trunks from http://www.chick.umist.ac.uk/
data from the UMIST/Nottingham/Dundee universities chicken EST sequencing project.
82% to human CYP51 81% to Fugu CYP51
MLSLLEVGGSLLERAAVGNPLSLLLAASAFALSLGYLFQLGYRRHVGADRTNH
PPHIPSSIPFLGHAIAFGKSPIEFLENAYDKYGPVFSFTMVGK
TFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNVVFLEQKKMLKTGL
NIAQFKQHVTLIEEETKEYFKAWGESGERNLFEAFSELIILTASHCLHGKEIRSLLNEKV
AQLYADLDGGFTHAAWLLPAWLPLPSFRRRDRAHRAIKNIFYKVIQKRRSSEEKEDDMLQ
TLLDASYKDGRPLTD
DEIAGMLIGLLLAGQHTSSTTSAWLGFFIARDKAIQEQCYAEQKAVCGDDLPPLTYDQLK
DLSLLDRCLKETLRLRPPIMTIMRLAKTPQTVAGYSIPPGHQVCVSPTVNQRLKDSWKDA
LDFKPDRYLRDNPAAGEKFAYIPFGAGRHRCIGENFAYVQIKTIWSTLLRLYEFDLVDGY
FPSINYTTMIHTPNNPVIRYKRRSL*
CYP51A1 Xenopus laevis (African clawed frog)
No accession number
Hiroaki Ohi, Yoshiaki Fujita
78-80% identical to mammalian CYP51s
submitted to nomenclature committee July 26, 2000
CYP51A1 Xenopus laevis (African clawed frog)
from parts BE669335 BE026950 BE026223 BE575528 seq 17
51-324
IPFLGHAIAFGKSPISFLENAYDKYGPVFSFTMVGKTFTYLVGSDAAALMFNSKNEDLNA
EDVYSRLTTPVFGKGVAYDVPNPIFLEQKKMLKTGLNIAHFKTHVEMIEEETQEYFERWG
DSGVRNLFEALSELIILTASRCLHGKEIRSMLNERVAQLYADLDGGFTHAAWLLPGWL
PLPSFRRRDRAHREIKNIFYQVIQKRRNSAEREDDMLQTLLDATYKDGTPVNDDEIAGML
IGLLLAGTHTSSTTSAWMGILLAQNKSLQNQCFAEQ
325-336
KPDSGEDCLPLN
337-484
YDQLRDLQVWDRCIKKTLRLRPPIMTMMRMARTPQSVAGYNIPPGHQVCVSPTVNHRLKD
TWDKNTEFNPNRYLHDNPAAGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMIRLYEFE
LVDGYFPTINYTTMIHTPNNPVIRYKRRKI*
CYP51A1a Xenopus laevis (African clawed frog)
SwissProt A2BD59
96% to CYP51A1 X. tropicalis
MMLFSLWEAGGTLLEEAVGGSLASRVLIPCTFLLALAYVSKLAFKHLLQTEDPGNVKYP PYISSHIPFLGHAITFGKSPISFLENAYDKYGPVFSFTMVGKTFTYLVGSDAAALMFNS KNEDLNAEDVYSRLTTPVFGNGVAYDVPNPIFLEQKKMLKTGLNIAHFKTHVEMIEEET QEYFERWGDSGVRNLFEALSELIILTASRCLHGKEIRSMLNERVAQLYADLDGGFTHAA WLLPGWLPLPSFRRRDRAHREIKNIFYQVIQKRRNSAEREDDMLQTLLDATYKDGTPLN DDEIAGMLIGLLLAGQHTSSTTSAWMGFFLAQNKSLQNQCFAEQKAVCGEDLPPLNYDQ LKDLQVLDRCIKETLRLRPPIMTMMRMARTPQSVAGYNIPPGHQVCVSPTVNHRLKDTW DKNTEFNPNRYLHDNPAAGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMIRLYEFEL VDGYFPTINYTTMIHTPNNPVIRYKRRKI
CYP51A1b Xenopus laevis (African clawed frog)
SwissProt Q66IT2
95% to CYP51A1 X. laevis A2BD59 CYP51A1a
96% to CYP51A1 X. tropicalis
presumed ohnolog of SwissProt A2BD59
MLLSLWEAGGTLLEEAVGGSLASRVLIPCTFLLALAYVSKLAFKHLMAEDPGNVKYPPY ISSNIPFLGHAIAFGKSPISFLENAYDKYGPVFSFTMVGKTFTYLVGSDAAALLFNSKN EDLNAEDVYSRLTTPVFGKGVAYDVPNPIFLEQKKMFKTGLNIAHFKTHVQMIEEETKE YFERWGDSGVRNLFEALSELIILTASRCLHGKEIRSMLNERVAQLYADLDGGFTHAAWL LPGWLPLPSFRRRDRAHREIKNIFYQVIQKRRNSAEREDDMLQTLIDATYKDGTPLNDD EIAGMLIGLLLAGQHTSSTTSAWMGFFLAQKKSLQDQCFAEQKAVCGEDLPPLNYDQLK DMQVLDRCIKETLRLRPPIMTMMRMARTPQSVAGYNIPPGHQVCVSPTVNHRLRDTWDK NTEFNPDRYLHDNPAAGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRTYEFELVD GNFPTINYTTMIHTPNDPLVRYKRRKN
CYP51A1 Xenopus tropicalis (Western clawed frog)
NM_001016194.2
80% to CYP51 human, ortholog
MLLSLWEAGGTLLEEAVGGSLASRILIPCTFLLALAYVSKLAFK
HLQAEDPGNVKYPPFISSNIPFLGHAIAFGKSPISFLENAYDKYGPVFSFTMVGKTFT
YLVGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPIFLEQKKMLKTGLN
IAHFKTHVQMIEEETQEYFERWGDSGVRNLFEALSELIILTASRCLHGKEIRSMLNER
VAQLYADLDGGFTHAAWLLPGWLPLPSFRRRDRAHREIKNIFYQVIQKRRNSAEREDD
MLQTLLDATYKDGTPLNDDEIAGMLIGLLLAGQHTSSTTSAWMGFFLAKNKSLQAQCF
AEQKAVCGEDLPPLNYDQLKDLQALDRCIKETLRLRPPIMTMMRMARTPQSVAGYNIP
PGHQVCVSPTVNHRLRDTWDKNTDFNPDRYLHDNPAAGEKFAYVPFGAGRHRCIGENF
AYVQIKTIWSTMLRMYEFELVDGYFPTINYTTMIHTPNNPVIRYKRRKN
CYP51A1 Danio rerio (zebrafish)
Seq zebrafish pages for seq
CYP51A1 Fugu rubripes (pufferfish)
No accession number
Scaffold_437
78% to 51 mouse
67511 MSAHLYEMSSKLIGDTVGRVHD
67445 NLTTVVLAASFITLSLGYVSKLLLRQSFVTDA (0)
KHPPYI 67266
67265 PSCIPFLGHAISFGKSPIEFLENAYEK 67185
66989 YGPVFSFTMVGSTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNP 66813
IFLEQKKMLKTGLNIAHFKEHVKIIEAETRE 66633
66632 YFQRWGDSGER 66600
66525 DLFEALSELIILTASSCLHGKEIRSMLDERVAQLYADLDGGFTHAA 66388
WLLPGWLPLPSF
66277 RKRDRAHREIKKIFFKVIEKRRRSGENTDDILQTLVDATYK
DGRPLSDDEIGGMLIGLLLAGQHTSSTTSAWMGFFMARDRRLQ 65918
65917 ERCYAEQKAACGEDLPPLSFDQ 65852
LKDLSLLEGCLKETLRLRPPIMTMMRMARSPQ
TAAGYTIPVGHQVCVSPTVNHRLGDAWEQRLEFKPDRYLDDNPAAGEKFAYI 64964
64963 PFGAG
RHRCIGENFAYVQIKTIWSTLLRMYEF 64784
64783 DLVDGYFPTINYTTMIHTPHNPVIRYKRRHE* 64688
CYP51A1 Tetraodon nigroviridis (freshwater pufferfish)
91% TO FUGU
MSMHLYEMSSKLIGDTVGKVHDNLTTVVLAASFITLSLGYISKLLLSQPCLKDA (0)
YGPVFSFTMVGNTFTYLLGSE &
TATLLFNSRNEDLNAEDVYSRLTTPVFGKGVAYDVPNP (0)
IFLEQKKMLKTGLNIARFKEHVKIIEAETREYFQRWGDSGER (1)
NLFEALSELIILTASSCLHGREIRSLLDERVAQLYADLDGGFTHAAWLLPGWLPLPSFR (2)
KRDRAHQEIKNIFFKVIQKRRKSGENTDDILQTLIDATYK (2)
DGRPLSDNEIAGMLIGLLLAGQHTSSTTSA &
WMGFFLARDQAVQERCYAEQKAVCGQDLPPLTFDQ (0)
LKELSLLERCLKETLRLRPPIMTMMRMARSPQ (0)
TAAGYTIPVGHQVCVSPTVNHRLYDAWEQRLEFQPDRYLHDNPAAGEKFAYIPFGA (1)
GRHRCIGENFAYVQIKTIWSTLLRMYQFDLADGYFPSINYTTMIHTPHNPVIRYKRRSE*
CYP51A1 Monosiga brevicola (choanoflagellate)
single celled sister group to all animals)
From JGI site estExt_fgenesh1_pg.C_250046 [Monbr1:38433]
51% to CYP51A1 of human
MDKLPAAVVPYAEAAQEALVSLHETLGRPSTTTYLATSAVALGIWKYIRGNYLRPAKAPPKVPSQVPWLG
CIFAFGQSPIEFMIDCYKKYGPVYSFVMFGTEVTYLLGSEASSRFWSTHNDVLNAEDLYANITVPVFGEG
VAYAVEHKIFSEQKQMAKEGLTIDRFKAYTSMIEKETNGFIERWGQTGTIDFFDNMARMIIYTATRCLHG
NETREDFDEDVAKLYHALDGGFTPQAWFFPPWLPLPSFRRRDRAHRELKERFYKIIDRRRQKAEEGTQTD
LMHTFMTTPYKNVEDGRHLTTDEVSGMMIALLMAGQHTSSTVSSWLTCFITTTPGLEEKLYQEQVELFKR
RPGPLSYEHINEMPLLWACIRETLRLRPPIMSIMRRAREDYKVTVNGVEYVIPKGSQVCVSPTVNGRLED
EWEDPNTFNPYRFLKEEDGKLVVTEGEQITKGGKFKWVPFGAGRHRCIGFGFAQVQIRCIMSTILRKYKL
EMVSGKLPPINYTTMIHTPTEPIVRYTRR*
CYP51A1 Caenorhabditis elegans (nematode worm/ mammalian contamination)
no accession number
F54E5 contig 00150 this fragment's amino acid translation is identical
to human sequences U51688, AC000120 and rat sequence AB004091.
DVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAA
WLLPGWLPLPSFR
The human sequences U23942, U40053 and D55653 and the rat sequences
U17697, D55681, D87997, D78370 all have N instead of D at the first
amino acid. This may be a polymorphism in this gene. It is very
unlikely that this sequence is from C. elegans and it most likely
represents a contamination by a mammalian sequence.
CYP51B1 Mycobacterium tuberculosis
GenEMBL Z80226
This is named in the CYP51 family even though it is in bacteria
It always clusters with the other CYP51 sequences.
The activity of this enzyme has been demonstrated to be a 14 alpha
demethylase with preference for obtusifoliol.
Mike Waterman presented the crystal structure of this
protein at a recent meeting in Moscow in July 2000.
See the bacterial nomenclature page for more CYP51B sequences.
CYP51C1 Phaeodactylum tricornutum (diatom)
GenEMBL BI307668.1
estExt_Genewise1.C_chr_310065|Phatr2 at JGI
note: one of the few P450s from diatoms (stramenopiles)
another is CYP97E1 from Skeletonema costatum
The CYP51C subfamily is for CYP51s in the Chromista
(Stramenopiles/heterokonts)
55% to Ectocarpus 51C1
MIVALVVVTGLTALWFFLLRPRTGGKHAPPVVTSSPLVPIPVIGHIVEFFRSPHFMMQRCLKDHGKVFTIPI
FHKRLTFL
IGPEAQEIFFKANDDVLSQSEVYDFTRPVFGNDVVYDASKKNRQVQFQTMANGLRTARLKAYIPKIEQETRAYIKNWGDA
GQIDLLKALSELTILTASRCLHGEDVRTHIFKEVQELYHDLDHGLTPLTVFWPTAPSQAHRKRDVARKEMVRLFTKVIEE
RQLHPERSDGTDILSLFMDIKYKDGSAVTMDQVTGLLIALLFAGQHTSCITSTWTSLFIANDPTLVSRILAEQKTVLGGD
LNKPIEYEDLQNMELLHNCMREALRMCPTFIMILRKAERDVKIQSEGKSYVIPQGDMVVVSPTVSMRMKETFADPDTYDP
DRFAAPREEHKQPYAYMGFGGGLHSCMGQNFAFLQVKTIISVLLREYELERVEPGMPDIGYDDMVVGPKGDCTVRYRKRV
QS*
CYP51C1 Thalassiosira pseudonana (diatom)
No accession
From JGI genome project
scaffold 68 48% to 51G1 Arabidopsis
66% to CYP51C Phaeodactylum tricornutum
55% to Ectocarpus 51C1
See stramenopile pages for a tree
This N-term is revised
1242369 MPFGFGSSTGPSDNLLIGLTCLAIFSLFYAFFVVRPRTKGGPHAPPVVTSSPVSSLPVVG
TIVEFGKSPVKMVQRCYEDYGPVFTVPV 1242106
FHKRLTFLIGPEAQEPFFKAPDEVLSQN
EVYGFMKPVFGPGIVYDASKKNRQVQFQSMANGLRTARLKGYTAKIERETRQYLESWGES
GELDLFHALSELTILTASRCLHGDDVRENLFKEVSELYHDLDQGLTPLTVFFPNAPTKSH
MKRNAARAKMVELFSKVIKNRRDNPDVQHSDGTDILSIFMDVKYKDGSNITDEQVTGLLI
ALLFAGQHTSCITSTWTSLFILNNPAILKRIIAEQNDVFGSQPDADVDYKMVNEDMPLLH
NSMKEALRLCPPLILLIRYALKDVKVKAAGKDYTIPKGDMVLISPSVGMRIPEVFKEPNT
FDPDRFGPDREEDKSSPFAYMGFGGGMHSCMGQNFAFVQVKTILSVLFREFELEMVSETM
PDIDYEAMVVGPKGDCRVRYKRRQ*
CYP51C1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAA4YI04FM1.SCF, LQ0AAA7YJ01FM1.SCF
LQ0AAB54YL14FM1.SCF, LQ0AAB79YH22FM1.SCF
LQ0AAB69YF16FM1.SCF, LQ0AAB65YF19FM1.SCF
LQ0AAA9YO17FM1.SCF, LQ0AAB58YH11FM1.SCF
LQ0AAB55YN02FM1.SCF, LQ0AAB70YE14FM1.SCF
LQ0AAB83YM18FM1.SCF, LQ0AAB2YA05FM1.SCF
59% to Diatom CYP51C1 Thalassiosira pseudonana (ortholog)
about 46% to Chlamydomonas CYP51G1
Ectocarpus sctg_6 1176507-1185087
CYP51D1 Dictyostelium discoideum (cellular slime mold)
GenEMBL AU033519
47% identical to S. bicolor CYP51 all the best matches are to CYP51
note: CYP51D is a subfamily for CYP51s from Dictyostelium and
other Mycetozoa
MIGTIAVLVIAILVIFAFKKSPSNIPPIVETIPFIGCFYQFAKNPLQLVRNSYDRLGEIF
TLHLMGFKMTFVLGPEAQALFFRGTDEELSPKEAYRFVTPVFGKGVVYDSETEIMYEQLR
FVKNGLVLSQLKKAVGIIQEETEKYFETKWGDSGEIDLLYEMNKLTILTASRCLMGKSIN
KSLGQSGQLADLYPNWKKVSIQFHSFSQISHYHHSKRETLPVLKSRHFPSIIQERRRSTD
DSVDDVLYTLMNSKYKDGSVLEDEQIVGLMIGLLFAGQHTSSITLTYTIFYLLNNLEYFD
ETQKDINDIVQKENQGEINFDGLKRMNRLETVIREVLRLHPPLIFLMRKVMTPMEYKGKT
IPAGHILAVSPQVGMRLPTVYKNPDSFEPKRFDVEDKTPFSFIAFGGGKHGCPGENFGIL
QIKTIWTVLSTKYNLEVGPVPPTDFTSLVAGPKGPCMVKYSKKQK*
CYP51E1 Trypanosoma brucei (African sleeping sickness parasite)
GenEMBL AZ217433 AQ948529 AQ950690 AL492728 AL481001 AZ217732
AQ948526 AQ647531 AL480043 AQ660405 AL495885 AZ212935 AL481816
Assembled from overlapping GSS fragments
33% to mammalian CYP51s
Note: CYP51E is a subfamily for CYP51s of Euglenozoa
Also AAHB01000003.1 T. brucei chromosome 11, comp (1400971-1402470)
MLLEVAIFLLTALALYSFYFVKSFNVTRPTDPPVYPVTVPILGHIIQFGKSPLGFMQECKRQL
KSGIFTINIVGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAAPYPRMREQ
LNFLAEELTIAKFQNFVPAIQHEVRKFMAANWDKDEGEINLLEDCSTMIINTACQCLFGEDLRKRLDARRFAQ
LLAKMESSLIPAAVFLPILLKLPLPQSARCHEARTELQKILSEIIIARKEEEVNKDSSTSDLLSGLLSAVYRDGTPMSLHEV
CGMIVAAMFAGQHTSSITTTWSMLHLMHPANVKHLEALRKEIEEFPAQLNYNNVM
DEMPFAERCARESIRRDPPLLMLMRKVMADVKVGSYV
VPKGDIIACSPLLSHHDEEAFPEPRRWDPERDEKVEGAFIGFGAGVHKCIGQKFGLLQVK
TILATAFRSYDFQLLRDEVPDPDYHTMVVGPTASQCRVKYIRRKAAAA*
CYP51E1 Trypanosoma brucei (African sleeping sickness parasite)
GenEMBL AF363026
Joubert,B.M., Nguyen,L.N., Matsuda,S.P.T. and Buckner,F.S.
Cloning and functional characterization of a Trypanosoma brucei
lanosterol 14 alpha-demethylase gene
Mol. Biochem. Parasitol. 117 (1), 115-117 (2001)
CYP51E1v1 Trypanosoma cruzi (Chagas disease parasite)
GenEMBL AY283022.1
Buckner,F.S., Joubert,B.M., Boyle,S.M., Eastman,R.T., Verlinde,C.L.
and Matsuda,S.P.
Cloning and analysis of Trypanosoma cruzi lanosterol
14alpha-demethylase
Mol. Biochem. Parasitol. 132 (2), 75-81 (2003)
Submitted by Sean M. Boyle for Fred Buckner Oct 25, 2001
83% to CYP51 of T. brucei
clone name CL13
CYP51-1 allele (only 3aa diffs to allele 2)
MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGH
IVQFGKNPLEFMQRCKRDLKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREV
YTIMTPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKE
DEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWL
LRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRM
SLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDN
VMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEE
AFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRD
EVPDPDYHTMVVGPTLNQCLVKYTRKKKLPS
CYP51E1v2 Trypanosoma cruzi (Chagas disease parasite)
GenEMBL AY283023.1
Buckner,F.S., Joubert,B.M., Boyle,S.M., Eastman,R.T., Verlinde,C.L.
and Matsuda,S.P.
Cloning and analysis of Trypanosoma cruzi lanosterol
14alpha-demethylase
Mol. Biochem. Parasitol. 132 (2), 75-81 (2003)
Submitted by Sean M. Boyle for Fred Buckner Oct 25, 2001
4 amino acid difference to CYP51E1v1
CYP51-2 allele, clone name WTB9
MFIEAIVLALTALILYSVYSVKSFNTTRPTDPPVYPVTVPFLGH
IVQFGKNPLEFMQRCKRELKSGVFTISIGGQRVTIVGDPHEHSRFFSPRNEILSPREV
YTIMTPVFGEGVAYSAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMAENWKK
DEGVINLLEDCGAMIINTACQCLFGEDLRKRLNARHFAQLLSKMESSLIPAAVFMPWL
LRLPLPQSARCREARAELQKILGEIIVAREKEEASKDNNTSDLLGGLLKAVYRDGTRM
SLHEVCGMIVAAMFAGQHTSTITTSWSMLHLMHPKNKKWLDKLHKEIDEFPAQLNYDN
VMDEMPFAERCVRESIRRDPPLLMVMRMVKAEVKVGSYVVPKGDIIACSPLLSHHDEE
AFPNPRLWDPERDEKVDGAFIGFGAGVHKCIGQKFALLQVKTILATAFREYDFQLLRD
EVPDPDYHTMVVGPTLNQCLVKYTRKKKLPS
CYP51E1 Trypanosoma congolense
Sanger Center congo469h11.p1k, congo931d01.p1k,
congo605h04.p1k
MLLEIVIFLLTAAALYAVYFVKSFNTTCVTDPPVYPVVLPFVGHILQFGRNPLEFMRKCK
RELGSGIFTINILGKRVTIVGDPHEHSRFFLPRNEVLSPREVYSFMVPVFGEGVAYAASY
PRMREQLNFLAEELTIAKFQNFVPAIQHEVRKFMVAHWDKEEGEINLLEDCSTMIINTAC
QCLFGEDLRRRLDARRFARLLAMMESSLIPAAVFAPFLLRLPLPQSARCHEA
RAELQQILSEIVISRKKEEVNRDSSTSDLLSGLLNAVY
RDGTPMSLHEVCGMIVAAMFAGQHTSSITT
TWSMLHLMHPSNKRHLETLRGEVEEFPAQLNYNNVMDEMPF
AERCARESIRRDPPLLMLMRKV
MSDVKVGPYVVPKGDIIACSPLLSHHDEEAFPDPRHWDPEREEKVEGAFIGFG
AGVHKCIGQKFGLLQVKTVLATVFRDYDFQLLRDQVPDPDYHTMVVGPTYSQCRVKYIRRKVVTA*
CYP51E1 Trypanosoma vivax
Contig7098.1
86% to 51E1 T. brucei
MLLEVITFLLTVLVLYSVYFVVSFNVTRPTDPPVRH
VALPFLGHIIPFGKDPLGFMLECKRKLRSGVFTINIMGKRVTVVGDPREHSRFFLPRNEV
LSPREVYAFMVPVFGEGVAYAAPYPRMREQLNFLAEELTIAKFQNFVPAIQHEARKFLSE
NWNKDEGQVNLLEDCSAMIINTACQCLFGEDLRKRLDARRFAQLLAKMESSLIPAAVFMP
SLLLLPLPQSACCRDAREELQLILSEIILARKREEVNKDSGTSDLLSGLLSAVYRDGTPM
SLHEVCGMIVAAMFAGQHTSTITTTWSLLHLMHPSNRKHLETLRKEIEEFPAQLNYSNVM
DEMPFAERCARESIRRDPPLIMLMRKVLADVKVGSYVVPKGDIIACSPLLSHHDEEAFPD
PRRWDPEREEVIEGAFIGFGAGVHKCIGQKFGLLQVKTILATVLRDYDFELPRDEVPEPD
YHTMVVGPTSSQCRVRYIRRKKPAS*
CYP51E1 Leishmania major (Leishmaniasis parasite)
LM7_11c.1.Contig2 L. major Friedlin chromosome 7_11c GenEMBL AZ048391
Also GenEMBL AZ048391 partial seq
76% to T. brucei CYP51E1
123423 MIGEFFLLLTAGLALYGWYFCKSFNTTRPTDPPVVHGAMPFVGHIIQFGKDPLDFMLNAK 123244
123243 KKYGGVFTMNICGNRVTVVGDVHQHNKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPY 123067
123066 PRMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTAC 122887
122886 QCLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDI 122710
122709 LSEIIIAREKEEAQKDSNTSDLLASLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTIT 122530
122529 TTWSLLHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEEMPFAEQCARESIRRDPPLIML 122350
122349 MRKVLKPVQVGKCVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAG 122170
122169 VHKCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIRKKA 121993
121992 AA 121987
CYP51E1 Leishmania infantum
Sanger Center Contig3290
8620 MIGELLLLLAAGLALYGWYFCKSFNTTRPTDPPVVHGTTPFVGHIIQFGKDPLGFMLKAK 8799
8800 KKYGGIFTMNICGNRITVVGDVHQHSKFFTPRNEILSPREVYSFMVPVFGEGVAYAAPYP 8979
8980 RMREQLNFLAEELTVAKFQNFAPSIQHEVRKFMKANWNKDEGEINILDDCSAMIINTACQ 9159
9160 CLFGEDLRKRLDARQFAQLLAKMESCLIPAAVFLPWILKLPLPQSYRCRDARAELQDILS 9339
9340 EIIIAREKEEAQKDTNTSDLLAGLLGAVYRDGTRMSQHEVCGMIVAAMFAGQHTSTITTT 9519
9520 WSLLHLMDPRNKRHLAKLHQEIDEFPAQLNYDNVMEEMPFAEQCARESIRRDPPLVMLMR 9699
9700 KVLKPVQVGKYVVPEGDIIACSPLLSHQDEEAFPNPREWNPERNMKLVDGAFCGFGAGVH 9879
9880 KCIGEKFGLLQVKTVLATVLRDYDFELLGPLPEPNYHTMVVGPTASQCRVKYIKKKKAA 10056
CYP51E1 Euglena gracilis
GenEMBL EC678643.1 EC676958.1 EC676055.1 (N-term ESTs)
EC672115.1 (C-term EST)
51% to CYP51G1 Arabidopsis
MKLGVALAGAAALIAAPVVIVAFLRPKRGTAPLVPAPPVVGSLFDFMRSPLKFV
KAAHEKYGDCFTVNICHKRLTFLIGPQAHQKFFKPNDQQLDQAKVYQFNVPVFGPGVVFD
ADLDRRLQQFGFIQKALKPHLMKTYVRQMVEEAEDYFSSWDQEGIIDLREKLSELVIMTA
SRCLMGKEVREQLFAEVARLYHDLDEGMQPISVFFPYLPIEKHRRRDIARLEMVKLFSKV
LEQR
NPDVYDPDRFAEPRMEDKKNGPFAFISFGGGRHTCLGEHFGMLQVKVIVAVLLQHFDLEL
IEGLPEPDYAAMIVGPKPIHIKYRRVPKRF*
Note: CYP51F is a subfamily for fungal CYP51 sequences
CYP51F1 Saccharomyces cerevisiae (yeast)
GenEMBL U10555 (24,431bp)
Johnston,M., Andrews,S., Brinkman,R., Cooper,J., Ding,H., Dover,J.,
Du,Z., Favello,A., Fulton,L., Gattung,S., Geisel,C., Kirsten,J.,
Kucaba,T., Hillier,L., Jier,M., Johnston,L., Keppler,D.,
Langston,Y., Latreille,P., Louis,E., Macri,C., Mardis,E.,
Mouser,L., Nhan,M., Rifken,L., Riles,L., St.Peter,H., Thornton,L.,
Trevaskis,E., Vaudin,M., Vaughan,K., Vignati,D., Wilcox,L.,
Willis,A., Wilson,R., Wohldman,P. and Waterston,R.
The complete sequence of Saccharomyces cerevisiae chromosome VIII
Science 265, 2077-2082 (1994)
YHR007c reverse complement of 20,961-22,553, ERG11 gene
CYP51F1 Saccharomyces cerevisiae (yeast)
GenEMBL T17568 (45bp)
Burns,N., Grimwade,B., Ross-Macdonald,P.B., Choi,E.-Y., Finberg,K.,
Roeder,G.S. and Snyder,M.
Large-Scale Analysis of Gene Expression, Protein Localization and
Gene Disruption in Saccharomyces cerevisiae
Genes Dev. 8, 1087-1105 (1994)
CYP51F1 Saccharomyces paradoxus
Spar_10379
98% to 51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Saccharomyces mikatae
Smik_9639
96% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Saccharomyces kudriavzevii
Skud_Contig2067.14
96% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Saccharomyces bayanus
Sbay_23211
93% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Saccharomyces castellii
Scas_Contig699.20
78% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Saccharomyces kluyveri
Sklu_Contig2436.11
79% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Kluyveromyces waltii
kwal_154-g13.1
77% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Kluyveromyces polysporus
Kpol_1004p61
81% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Kluyveromyces lactis
76% to CYP51F1 Saccharomyces kluyveri
see fungal pages for seq
CYP51F1 Ashbya gossypii ATCC 10895
NP_984259.1
71% to CYP51F1 S. cerevisiae,
see fungal pages for seq
CYP51F1 Yarrowia lipolytica
CAG82748.1
63% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F1 Penicillium italicum
GenEMBL Z49750 (2053bp)
Nistelrooy,H.G.M., Van den Brink,H.M., Kan,J.A.L., Gorcom,R.F.M.
and Waard,M.A.
Isolation and molecular characterisation of the gene encoding
eburicol 14-alpha-demethylase (CYP51) from Penicillium italicum
Unpublished (1995)
CYP51F1 Uncinula necator (grape powdery mildew fungus)
GenBank U72657 (1960bp) U83840 (1756bp) U72658 (1575bp)
Delye,C., Laigret,F. and Corio-Costet,M.F.
Cloning and sequence analysis of the eburicol 14alpha-demethylase
gene of the obligate biotrophic grape powdery mildew fungus
Gene 195 (1), 29-33 (1997)
note: a mutation causing resistance to an inhibitor triadimenol is
Y136F
Delye,C., Laigret,F. and Corio-Costet,M.F.
A mutation in the 14 alpha-demethylase gene of Uncinula necator that
correlates
with resistance to a sterol biosynthesis inhibitor.
Applied and Environ. Microbiol. 63, 2966-2970 (1997)
CYP51F1 Schizosaccharomyces pombe
GenEMBL Z54096 (12168bp)
Hunt,S. Devlin,K. and Churcher,C.M.
unpublished (1995)
CYP51F1 Schizosachharomyces japonicus
SJAG_03750
78% to Schizosachharomyces pombe CYP51A1
see fungal pages for seq
CYP51F1 Schizosachharomyces octosporus
SOCG_01956
see fungal pages for seq
CYP51F1 Pneumocystis carinii
AY228706
contig_349-snap.1 from Fungal Genome DB
contig_349-snap.2 from Fungal Genome DB
58% to CYP51F1 S. pombe
see fungal pages for seq
CYP51F1 Ustilago maydis
GenEMBL Z48164 (1874bp)
Hargreaves,J.A. and Keon,J.P.R.
The sterol 14 alpha demethylase (ERG11) gene from Ustilago maydis.
Unpublished (1994)
CYP51F1 Ustilago maydis
GenEMBL XM_401277
locus_tag="UM03662.1
CYP51F1 Puccinia graminis f. sp. tritici
PGTG_07202 revised
55% to CYP51F1 Malassezia globosa with a short seq gap.
see fungal pages for seq
CYP51F1 Malassezia globosa
MGL_2415
67% to CYP51F1 Ustilago maydis,
see fungal pages for seq
CYP51F1 Sporobolomyces roseus
JGI model e_gw1.1.480.1
55% to CYP51F1 Ustilago maydis,
see fungal pages for seq
CYP51F1 Issatchenkia orientalis
GenEMBL S75391 (1242bp)
Burgener-Kairuz,P. Zuber,J.P., Buchman,T.G., Bille,J. and Rossier,M.
Rapid detection and identification of Candida albicans and
Torulopsis (Candida) glabrata in clinical specimens by species-specific
nested PCR amplification of a
cytochrome P-450 lanosterol-alpha-demethylase (L1A1) gene fragment.
J. Clin. Microbiol. 32, 1902-1907 (1994)
CYP51F1 Kluyveromyces marxianus
GenEMBL X97682 (338bp)
Morace,G., Posteraro,B., Sanguinetti,M., Lo Cascio,G. and Fadda,G.
Identification of various medically important Candida species in
clinical specimens by using PCR-REA.
Unpublished
88% to CYP51F1 Kluyveromyces lactis
CYP51F1 Erysiphe graminis f. sp. hordei eburicol
GenEMBL AF052515 (2167bp)
Delye,C., Bousset,L. and Corio-Costet,M.F.
PCR cloning and detection of point mutations in the eburicol
14alpha-demethylase (CYP51) gene from Erysiphe graminis f. sp.
hordei, a 'recalcitrant' fungus.
Curr. Genet. 34, 399-403 (1998)
CYP51F1 Candida tropicalis
GenEMBL M23673
Chen,C., Kalb,V.F., Turi,T.G. and Loper,J.C.
Primary structure of the cytochrome P450 lanosterol 14
alpha-demethylase gene from Candida tropicalis
DNA 7 (9), 617-626 (1988)
CYP51F1 Candida glabrata
GenEMBL S75389 (1242bp)
Burgener-Kairuz,P. Zuber,J.P., Buchman,T.G., Bille,J. and Rossier,M.
Rapid detection and identification of Candida albicans and
Torulopsis (Candida)
glabrata in clinical specimens by species-specific nested PCR
amplification of a
cytochrome P-450 lanosterol-alpha-demethylase (L1A1) gene fragment.
J. Clin. Microbiol. 32, 1902-1907 (1994)
CYP51F1 Candida glabrata S75389
GenPept CAG58795.1
see fungal pages for seq
CYP51F1 Candida parapsilosis
GenEMBL AF019902 (677bp)
Okhravi,N., Adamson,P., Mant,R., Matheson,M.M., Midgley,G.,
Towler,H.M. and Lightman,S.
Polymerase chain reaction and restriction fragment length
polymorphism mediated detection and speciation of Candida spp
causing intraocular infection.
Invest. Ophthalmol. Vis. Sci. 39 (6), 859-866 (1998)
CYP51F1 Candida parapsilosis
CPAG_03310
75% to CYP51F1 Candida tropicalis
see fungal pages for seq
CYP51F1 Candida albicans
GenEMBL X13296, orf19_922
Lai,M.H. and Kirsch,D.R.
Nucleotide sequence of cytochrome P450 L1A1 (lanosterol 14
alpha-demethylase) from Candida albicans
Nucleic Acids Res. 17, 804 (1989)
CYP51F1 Candida guilliermondii
GenEMBL X97680 (336bp)
Morace,G., Sanguinetti,M., Posteraro,B., Cascio,G.L. and Fadda,G.
Identification of various medically important Candida species in
clinical specimens by PCR-restriction enzyme analysis
J. Clin. Microbiol. 35 (3), 667-672 (1997)
CYP51F1 Candida guilliermondii
PGUG_03415.1
71% to CYP51F1 Candida lusitaniae
see fungal pages for seq
CYP51F frag. Candida guilliermondii X97680
this seq is 94% to Candida albicans but only 66% to
full length CYP51A1 for C. guilliermondii
This is a different gene
MTDQEIANLLIVILMGGQHTSTSAWFLLHLGEKPHLQDVIYQEV
VELLKEKGGDLNDLTYEDLQKLPSVNNTIKETLRMHMPLHSTFRKVTNPLRSPNKYMS
SHTVYMFKFL
CYP51F1 Candida dubliniensis P450L1A1, partial.
GenEMBL AJ012573
Morace,G., Posteraro,B., Sanguinetti,M. and Fadda,G.
Identification of various medically important yeast by Reverse
Cross Blot Hybridization
Unpublished
MTDQEIANLLIGILMGGQHTSASTSAWFLLHLGEKPHLQDAIYQ
EVVELLKEKGGDLNDLTYEDLQKLPSVTNTIKETLRMHMPLHSIFRKVKNPLRIPETNYVVPRGHYVLVSPG"
CYP51F1 Candida dublinensis
93% to CYP51F1 Candida albicans, cdub_2-g61.1, GenEMBL AJ012573
see fungal pages for seq
CYP51F1 Candida lusitaniae
CLUG_04932.1
72% to CYP51F1 Candida tropicalis
see fungal pages for seq
CYP51F1 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
61% to CYP51F1 Debaryomyces hansenii
CYP51F1 Lodderomyces elongisporus
LELG_03738
77% to CYP51F1 Candida parapsilosis
see fungal pages for seq
CYP51F1 Pichia anomala
GenEMBL AF019903
Okhravi,N., Adamson,P., Mant,R., Matheson,M.M., Midgley,G.,
Towler,H.M. and Lightman,S.
Polymerase chain reaction and restriction fragment length
polymorphism mediated detection and speciation of Candida spp
causing intraocular infection
Invest. Ophthalmol. Vis. Sci. 39 (6), 859-866 (1998)
CYP51F1 Pichia stipitis
JGI model e_gww1.7.1.351.1
71% TO CYP51F1 Debaryomyces hansenii
see fungal pages for seq
CYP51F1 Debaryomyces hansenii
GenPept CAG88416.1
75% to CYP51F1 Candida guilliermondii
see fungal pages for seq
CYP51F1 Neurospora crassa
No accession number
Neurospora crassa sequence contig 1.721 (supercontig 99)
Lower case = EST support
49163 MGILQVVAGPLSQQFSQLGTVSQIGVAIASFLFVAVVLNVLQQFLFKKPNEPPLVFHWFP 49342
49343 LIGSTITYGMDPPRFFKENREK (0)
YGDCFTFILLGKKT 49522
49523 TVYVGPKGNDFILNGKIRDVNAEEIYTVLTTPVFGKDVVYDCPNsklmeqkk 49678 (0)
49741 fmkialtteafrqyvpiisdevtsylkrtadfkgksgivdippkmaqitiftashalqg 49917
49918 keirdkfdetladlyhdldmgfspinfmlhwaplpwnnrrdyaqrtvakiymdtikerra 50097
50098 rgetgaqdimwhlmnstykgdvpvpdheiahmmiallmagqhsssstsswimlrlasr 50271
50272 pdimedlyneqvknlgadlppltyedlaklplhaaivkETLRLHAPIHSIMRAVKTPMPV 50451
50452 PGTKYVIPTDHVLLAAPGVSATDESYFPQPDLWEPHRWEKDSPLAPTIVRNVPSEEDDEK 50631
50632 IDYGYGLVSKGANSPYLPFGAGRHRCIGEQFANVQLQTILAIIVRNFKFRNVDGSDkvig 50811
50812 tdyaslfsrplepakiywerregcql* 50892
CYP51F1 Neurospora discreta
JGI gene model estExt_fgenesh3_kg.C_20410
98% to CYP51F1 N. crassa
see fungal pages for seq
CYP51F1 Aspergillus nidulans
AACD01000145 (WGS section)
AN8283.2
51 clan
MGLVSLVLDNVCERCSALSVWALSGLGLLSVIIIAVVLNVLRQILFKNPN
EPPVVFHWFPFIGSTISYGIDPYKFFFNCRAQYGDIFTFVLLGKKTTVYL
GTKGNDFILNGKLKDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFV
KYGLTSDALRSYVQLITAEVEDFAQKSSVFQNAKGVFDVSRTIAEITIYT
ASRSLQGKEVRDKFDSTFAELYHDLDMGFAPINFMLPYAPLPHNRKRDAA
QRKMAETYMEIIKERRKSGEKKDSEDMVWNLMSCVYKNGTPLSDEEIAHM
MIALLMAGQHSSSSTLSWILLHLARHPEIVEELYQEQLKVLGSDMHMTYD
DLQKLELHSKIIKETLRIHAPIHSIIRAVKSPMPVPGTSYVIPTSHNVLS
SPGVTARSDEFFPNPLKWDPHRWDSNPIANSTEDEEKIDYGYGLVSKGTN
SPYLPFGAGRHRCIGEQFAYVQLITVTAALVRLFKFDTVSESDKSSVPET
DYSSLFSRPAGKCFVQYEKRNVTTKA*
CYP51F1 Magnaporthe grisea
AACU01001110 cont2.837
MG04432.4 (version4) 75% to CYP51
MGLLQDTTGPLVDAFYQLGTGAQVGVAFVSFIFLSVFFHVAQQIFFKNPH
EPPVVFSWFPVVGSTVTYGKDPPQFFRDMAKKYGNIFTFILLGKKTTVYI
GTEGNEFILNGKLRDVNAEEIYGPMTTPVFGKDVVYDCPNAKLMEQKKFM
KIALTTEAFRSYVPIIADEVSSYLKRTPAFKGPSGVVNIPPKMAEITIFT
ASHALQGKEIRDQFDETLADLYHDLDMGFHPVNFKLHWLPLPRNIRRDKA
QKTIAKIYMDTIQRRRAKGKDSEAKDMMYHLMNSTYKNGTPVPDHEIAHM
MIALLMAGQHSSSSTSSWIMLRLASRPDIMEELYQEQVRALGADLPPLRY
EDLANLPLHLAVIKETLRLHAPINSILRAVKQDLPVPGTNYVIAKDTTVL
AAPGYSAGDPNHFPEPELWEPHRWEADSRLAPRISMSNDNDEEEKIDYGY
GLVSKGTTSPYLPFGAGRHRCIGEHFANVQLQTIVAMIVREFKFRNVDGS
GKVVGTNYASLFSRPEEPAKIYWERR*
CYP51F1 Fusarium graminearum
AACM01000048 (WGS section)
FG01000.1 FGcontig1.48_scaffold1
64% to Erysiphe graminis 72% to M. grisea 51F1
MGLLQELAGHPLAQQFQELPLGQQVGIGFAVFLVLSVVLNVLNQLLFRNP
NEPPMVFHWFPFVGSTITYGMDPPTFFRENRAKHGDVFTFILLGKKTTVA
VGPAGNDFILNGKLKDVCAEEIYTVLTTPVFGKDVVYDCPNAKLMEQKKF
MKIALTTEAFRSYVPIISSEVRDYFKRSPDFKGKSGIADIPKKMAEITIF
TASHALQGSAIRSKFDESLAALYHDLDMGFTPINFMLHWAPLPWNRKRDH
AQRTVAKIYMDTIKERRAKGNNESEHDMMKHLMNSTYKNGIRVPDHEVAH
MMIALLMAGQHSSSSTSSWIMLRLAQYPHIMEELYQEQVKNLGADLPPLT
YEDLAKLPLNQAIVKETLRLHAPIHSIMRAVKSPMPVPGTKYVIPTSHTL
LAAPGVSATDSAFFPNPDEWDPHRWEADSPNFPRMASKGEDEEKIDYGYG
LVSKGSASPYLPFGAGRHRCIGEHFANAQLQTIVAEVVREFKFRNVDGGH
TLIDTDYASLFSRPLEPANIHWERRQ*
CYP51F1 Fusarium oxysporum
FOXG_00394
92% to CYP51F1 Fusarium graminearum
see fungal pages for seq
CYP51F1 Fusarium verticillioides
98% to CYP51F1 Fusarium oxysporum
FVEG_01123
see fungal pages for seq
CYP51F1 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_2000426
Necha1/scaffold_2:1348428-1350174
genome annotation in progress
89% to Fusarium graminearum CYP51F1
FG01000.1 AACM01000048 FGcontig1.48_scaffold1
This gene model seems correct DRN 2/4/06
MGLLHEIAGHPLAQQFQELPLGQQVGIGFGAIVVLSVILNILSQILFVNPNEPPMVFHWFPFIGSTVTYG
MDPPRFFKENRAK (0)
FGDVFTFVLLGKKTTVAVGPSGNDFILNGKLKDVCAEEIYTVLTTPVFGKDVVYDCPNAKLMEQKK (0)
FMKIALTTEAFRSYVPIISGEVRDYFKKSADFKGKTGIVDIPKKMAEITIFTASHALQGSV
IRSKFDESLAALYHDLDMGFTPINFMLHWAPLPWNRKRDHAQRTVAKIYMDTIRERRIKDNDDSEHDMMK
HLMNSTYKNGTPVPDHEIAHMMIALLMAGQHSSSSTSSWIMLRLAQYPQIMEELYQEQVKALGADLPPLK
FEDLAKLPLNQAIIKETLRLHAPIHSIMRAVKSPMPVPGTKYVIPTSHTLLAAPGVSASDPAYFPNPDEW
DPHRWEAGSPNAPTIARNNAEEEEKIDYGYGLVSKGSASPYLPFGAGRHRCIGEHFANVQLQTIVAEVVR
EFKFSNVDGGNTLIGTDYASLFSRPLEPANIRWERRQ*
CYP51F1 Aspergillus fumigatus
GenEMBL AAK73660.1 also XP_749134.1, EAL87096.1
14-alpha sterol demethylase
79% to 51F1 A. nidulans
MGLIAFILDGICKHCSTQSTWVLVGIGLLSILAVSVIINVLQQLLFKNPHEPPVVFHWFPFIGSTISYGI
DPYKFFFDCRAKYGDIFTFILLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPN
AKLMEQKKFVKYGLTSDALRSYVPLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEV
RSKFDSTFAELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGSKKDSEDMVWN
LMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELYQEQIRVLGSDLPPLTY
DNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYVIPTSHNVLSSPGVTARSEEHFPNPLEWN
PHRWDENIAASAEDDEKVDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFRFRNLP
GVDGIPDTDYSSLFSKPLGRSFVEFEKRESATKA
CYP51F1 Neosartorya fischeri NRRL 181
XM_001261294.1, NFIA_024690
98% to CYP51F1 A. fumigatus = ortholog
63% to CYP51F2 A. fumigatus
MGLIAFILDGICKHCSTQSTWVLVGVGLLSILAVSVIANVLQQL
LFKNPHEPPVVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGT
KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKYGLTSDALR
SYVPLITDEVESFVKNSPAFQGHKGVFDVCKTIAEITIYTASRSLQGKEVRSKFDSTF
AELYHNLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQTGSKKDSED
MVWNLMSCVYKNGTPVPDEEIAHMMIALLMAGQHSSSSTASWIVLRLATRPDIMEELY
QEQIRVLGSDLPPLTFDNLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMAVDGTSYV
IPTSHNVLSSPGVTARSEEHFPNPLEWDPHRWDEDIAASAEDDEKVDYGYGLVNKGTN
SPYLPFGAGRHRCIGEQFAYLQLGTITAVLVRLFKFRNLPGVDGVPDTDYSSLFSKPL
GRSFVEFEKRESATKA
CYP51F1 Aspergillus oryzae
GenEMBL BAE60239.1
79% to CYP51F1 Aspergillus nidulans, 60% to CYP51F4
MGILAVILDSVCERCSGSSLWMLSTVALLSILVVSVVINVLRQLLFKNYKEPPLVFHWFPFIGSTISYGM
DPYRFFFNCREKYGDIFTFVLLGKKTTVYLGTKGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPN
AKLMEQKKFVKFGLTSDALRSYVRLITEEVEDFVQKSSALQGPNGVFDVCKTIAEITIYTASRSLQGKEV
RSRFDSTFAELYHDLDMGFAPINFMLPWAPLPHNRKRDAAQKRMTETYMEIIKERRKAGSKKDSEDMVWN
LMSCMYKDGTPVPDEEIAHMMIALLMAGQHSSSSTAAWIVLHLAASPEITEELYQEQLRILGHDMPPLTY
ENLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVEGTPYVIPTSHNVLSSPGVTARSEEHFPDPLEWK
PHRWDEAIAVSSEDEEKVDYGYGLVTKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAALVRLFKFSNLP
GVQTLPDTDYSSLFSKPLGNSKIQFEKREPVTKA
CYP51F1 Aspergillus flavus
AFL2G_06478
100% to CYP51F1 Aspergillus oryzae
CYP51F1 Aspergillus niger
estExt_fgenesh1_pm.C_150008|Aspni1
84% to CYP51F1
MGLLAVVLDSLCERCSNTSVLVVLGFGLLSLLAVSVIFNILRQLFFKNPNEPPLVFHWFPFIGSTISYGMDPYKFFFDCR
AKYGDIFTFILLGKKTTVYLGTRGNDFILNGKLRDVCAEEVYSPLTTPVFGRNVVYDCPNAKLMEQKKFVKFGLTSDALR
SYVRLITGEVENFVEHSAAFKGSSGVFDVCKTIAEITIYTASRSLQGKEVRSRFDSTFAELYHDLDMGFAPINFMLPWAP
LPHNRKRDAAQKKMTETYMEIIKERRNGGNKKDSEDMVWNLMSCIYKDGTPVPDEEIAHMMIALLMAGQHSSSSTASWIV
LHLARNPQIMEELYAEQIRVLGSDLPPLTYDNLQKLDLHAKVIKETLRIHAPIHSIIRAVKNPMPVDGTPYVIPTSHNVL
SSPGVTARSEEYFPNPLKWDPHRWDETIAASAEEEDQIDYGYGLVSKGTNSPYLPFGAGRHRCIGEQFAYVQLGAITAAL
VRLFKFRNLPNVKDIPETDYSSLFSKPAGKSIIQFEKRATTIKS*
CYP51F1 Aspergillus clavatus NRRL 1
XM_001273213.1, ACLA_005420
89% to 51F1 S. fumigatus
61% to 51F2 A. fumigatus
MGLITDILDGVCKYCSTQSIWMLGGVGLLSLLAVAVVVNVLRQL
LFKNPNEPPLVFHWFPFIGSTISYGIDPYKFFFDCRAKYGDIFTFILLGKKTTVYLGT
KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKFGLTSDALR
SYVHLITDELESFVKSSSAFQGPKGVFDVCKTIAEITIYTASRSLQGKEVRNKFDSTF
AELYHDLDMGFAPINFMLPWAPLPHNRKRDAAQRKLTETYMEIIKARRQAGNEKDSED
MVWNLMSCVYKNGVPVPDEEIAHMMIALLMAGQHSSSSTAAWIVLRLATRPDIMEELY
QEQLRVLGSDLPPLTYDSLQKLDLHAKVIKETLRLHAPIHSIIRAVKNPMPVEGTPYV
IPTSHNVLSSPGVTARSEEHFADPLEWNPHRWDEHIVENDEDEEKIDYGYGLVNKGTN
SPYLPFGAGRHRCIGEQFAYVQLGTITAGLARLFKFRNLPDIEGIPDTDYSSLFSKPL
GKSVVQFEKREPALKA
CYP51F1 Aspergillus terreus NIH2624
XM_001212028.1, ATEG_02850.1
MGVFADIIGTLCEHCSTLSIWALGGAVLLAVFVLSVVINVLRQL
LFKNPHEPPVVFHWVPWIGSTIRYGIDPYKFFFECRAKYGDIFTFVLLGKKTTVYLGT
KGNDFILNGKLRDVCAEEVYSPLTTPVFGRHVVYDCPNAKLMEQKKFVKFGLTSDALR
SYARLITAEVDDFVKNSPTFQQPKGTFDVCKTIAEITIYTASRSLQGKEVRNRFDSTF
AEMYHDLDMGFAPINFVLPWAPLPHNRKRDAAQKKMAETYMEIIKERRQAGGKKDSED
MVWNLMSCVYKDGTPLPDEEIAHMMIALLMAGQHSSSSTASWIVLRLAENPEITEELY
QEQLRVLGSDLPPLTWDSLQKLDLHAKVIKETLRIHAPIHSIMRAVKNPMPVEGTPYV
IPTSHNVLSSPGVTARSEEYFSEPLKWDPHRWDETAAPSTEEEEETIDYGYGLVTKGT
NSPYLPFGAGRHRCIGEQFAYVQLGAITAALVRLFKFSNPPGANKLPDTDYSSLFSKP
LGKSYVQFEKRETNTKA
CYP51F1P Aspergillus terreus
ATEG_10302.1 revised
71% to CYP51F1 Aspergillus terreus
see fungal pages for seq
CYP51F1 Metarhizium anisopliae var. acridum Ma102
CYP51F1 Metarhizium anisopliae var. anisopliae Ma23
CYP51F1 Mycosphaerella graminicola
Fungal P450 Database Mgr032
63% to CYP51F1 Aspergillus fumigatus
see fungal pages for seq
CYP51F1 Mycosphaerella fijiensis
JGI model e_gw1.3.1317.1
81% to CYP51F1 Mycosphaerella graminicola
see fungal pages for seq
CYP51F1 Uncinocarpus reesii
UREG_07804.1
78% to CYP51F1 Ajellomyces capsulatus
see fungal pages for seq
CYP51F1 Coccidioides immitis
CIMG_07469.2
89% to CYP51F1 Uncinocarpus reesii
see fungal pages for seq
CYP51F1 Ajellomyces capsulatus NAm1 (Histoplasma capsulatum)
XM_001540158.1
63% to CYP51F2 A. fumigatus
74% to CYP51F1 A. fumigatus
MGLLADVVARVCAHCSTLSPWAFLLTGSATLIVLSVIINVLHQL
LWKNPNEPPVVFHWFPIIGSTISYGIDPYKFFLNCREKYGDIFTFVLLGKKTTVFLGT
KGNDFILNGKLKDVCAEEVYSPLTTPVFGSHVVYDCPNSKLMEQKKFVKYGLTSESLR
SYVTLITDEFNQYIKTSPAFQGDKGVLDVCKSIAEITIYTASRSLQGKEVRSKFDSSF
AQLYHDLDMGFTPINFMLPWAPLPHNRKRDAAQQKMTKIYTDIIRQRREAGGKKDSED
MVWNLMSCVYKDGTPLPDIEIAHMMIALLMAGQHSSSSTFSWIILRLASCPHIIEELY
EEQKQVLGEDLPPLTYETLQKLNLNSHVIRETLRIHAPIHSILRAVKSPMPVDGTRYT
IPTTHNLLAAPGVTSRLPEHFPNPMTWDPHRWENPAMAPEGDQSDEKLDYGYGLVSKG
ANSPYLPFGSGRHRCIGEQFAYVQLGTLLVAIVRQLKLKKLDGETGVPATDYSSLFSK
PLGKPLVAWERRNPTQK
CYP51F1 Histoplasma capsulatum G217B, teleomorph: Ajellomyces capsulatus
HCB02684.1 model is a fusion protein, top part deleted
96% to CYP51F1 Ajellomyces capsulatus NAm1
MGLLADVVARVCAHCSTLSLWALLLAGSASFIVLSVIINVLHQLLWKNPNEPPVVFHWFPIIGSTISYGIDPYKFFLNCR
EKYGDIFTFVLLGKKTTVFLGTKGNDFILNGKLKDVCAEEVYSPLTTPVFGRHVVYDCPNSKLMEQKKFVKYGLTSESLR
SYVTLITDEFNQYIKTSPAFQGDKGVLDVCKSISEITIYTASRSLQGKEVRSKFDSSFAQLYHDLDMGFSPINFMLPWAP
LPHNRKRDAAQQKMTKIYTDIIRQRREAGGKKDSEDMVWNLMSCVYKDGTPLPDVEIAHMMIALLMAGQHSSSSTLSWII
LRLASCPHIIEELYEEQKQVLGEDLPPLTYETLQKLNLNSHVIRETLRIHAPIHSILRAVKSPMPVDGTRYTIPTTHNLL
AAPGVTSRLPEHFPNPMTWDPHRWENPAMAQEEDQSGEKLDYGYGLVSKGANSPYLPFGSGRHRCIGEQFAYVQLGTLLA
AIVRQLKLKKLDGETGVPATDYSPLGKPLVAWERRNPTQK
CYP51F1 Venturia inaequalis strain Ent27
GenEMBL AF227920
14 alpha-demethylase
MGLLSPLLAXLPGSDRSWLFYTLASFGFTVAIVAANLVKQLLFS
NPNEPPVVFHWFPFFGNTVVYGIDPIKFFAECKEKHGDIFTFILLGRKTTVYIGTKGN
EFILNGKQSHVNAEEIYSPLTTPVFGSDVVYDCPNSKLMEQKKFVKYGLTTE ALKSYV
TLIQQEVEDYTKRYPQFKGEKGSFDVCASMAEITIFTASRSLQGKEVRDKFDASFADL
FHDLDMGFSPINFMLPWAPLPHNRRRDAANKKMTETYLEIIQSRKAEGVKKDSEDMIW
NLMQCVYKNGTPIPDKEIAHMMIALLMAGQHSSSSTSSWILLRLATRPDIQEELYQEQ
IRVCGADLPPLQYEDLARMPLHNQIIKETLRMHSPIHSILRAVKQPMPVEGTPYTIPT
SHVLLAAPIASGGSPMYFPAPEKWEPHRWDEGSGGTNISGGENGGEEKEDYGYGLITK
GASSPYLPFGAGRHRCIGEQFAYMQLNTVLATQVREFKFSLREGESFPKTDFSSLFSG
PLRPAWLNWERREKSS
CYP51F1 Phanerochaete chrysosporium (white rot fungus)
Scaffold_44, JGI gene model ug.2.6.1
54% to Ustilago maydis CYP51F1
MSLSQYGPIAGLVGQAYDALASMSTSRLVLFLLINIPILSV
LPKDKSLPPVVWHWFPWFGSAAAYGEDPIKFFFDCKEK
YGNVFTFILMGRKVTVALTPAGNNFIMGGKHTTFSAEEVYG
GLTTPVFGKDVVYDCPNELLMEQKKFVKFGLSTENFRQYVGMIEEEVLQFMRNDASFK
IYQMNDINEWGAFDVLKVMSEITILTASRTLQGKEVRANITKDYAQVYNDLDGGFTPLHF
MFPNLPLESYRKRDAAHKKISDFYISIIRKRRENPGQ
EEHDMIAALMNQKYRVGRPLKDHEIAHIMIALLMAGQHTSSATGSWALLHIADRPDVA
EALYEEQVKHFRQSDGSWRTPEYEELKELPVLDSVIRETLRIHPPIH
SIMRAVREDVVVPPTLAAPSEDGRYVIPKGHVVLSSAAISQVDPMLWKNANDWDPSRWSD
PEGVAAQAYKQYDDAEGAKVDFGFGLVSKGTDSPYQPFGAGRHRCIGEQFAYLQLGTIISTFVR
HVEMRLPETGVPPPNYHVRSHTRILRLVCADVASADDDHTPEGASQHSLQAA*
CYP51F1v1 Postia placenta (brown rot basidiomycete fungi)
CYP51F1v2 Postia placenta (brown rot basidiomycete fungi)
CYP51F1v3 Postia placenta (brown rot basidiomycete fungi)
CYP51F1 confidential basidiomycete
CYP51F1 Cryptococcus neoformans var. neoformans B-3501A chromosome 1
56% to CYP51F1 Phanerochaete chrysosporium
AAEY01000001
CNBA0300
ESTs gb|CF192489.1
gb|CF192488.1, gb|CF191439.1
EAL23379.1
see fungal pages for seq
CYP51F1 Cryptococcus gattii
CNBG_0513 Transcript 1 Broad Institute
96% to CYP51F1 Cryptococcus_neoformans var. neoformans B-3501A
revised to include 14 nucleotide micro exon
MSAIIPQVQQLLGQVAQYIPHWFTALPTSLKIVIAVIGIPAFIIGLNVFHQLCLPRRRDL
PPVVFHYIPWFGSAAYYGEDPYKFLFECRDKYGDLFTFILMGRRITVALGPKGNNLSLGG
KISQVSAEEAYTHLTTPVFGKGVVYDCPNEMLMQQKKFIKSGLTTESLQSYPPMITSECE
DFFTKEVGISSQKPSITLDLLKSMSELIILTASRTLQGKEVRESLNGQFAKYYEDLDGGF
TPLNFMFPNLPLPSYRRRDEAQKAMSDFYLKIMENRRKGESDHEHDMIENLQGCKYRNGV
PLSDRDVAHIMIALLMAGQHTSSATSSWTLLHLADRPDVVEALYQEQKEKLGNPDGTFRD
YKYEDLKELPIMDSIIRETLRM (0)
HAPIH (2)
SIYRKVLSDIPVPPSLAAPSENGQYIIPKGHYIMAAPGVSQMDPRIWQDAKVWNPAR
WHDEKGFAAAAMAQYTKAEQVDYGFGSVSKGTESPYQPFGAGRHRCVGEQFAYTQLSTIF
TYVVRNFTLKLAVPKFPETNYRTMIVQPNNPLVTFTLRNAEVKQEV*
CYP51F1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
RO3G_11790.1
46% to CYP51F1 Aspergillus fumigatus = CYP51F1
see fungal pages for seq
CYP51F1P Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
RO3G_08504.1 revised
60% TO CYP51F1 Rhizopus oryzae
see fungal pages for seq
CYP51F1 Grosmannia clavigera
CYP51F1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI model estExt_fgeneshPB_pg.C_10567
73% to CYP51F1 Rhizopus oryzae
see fungal pages for seq
CYP51F1 Batrachochytrium dendrobatidis JEL423 (chytrid)
BDEG_01891
43% to CYP51F1 Rhizopus oryzae
note this species has no obvious CYP61 sequence
see fungal pages for seq
CYP51F2 Aspergillus nidulans
AACD01000029 (WGS section)
AN1901.2
64% to 51F2, 60% to 51F1
MLSPTLFSAYVLVGAIVAVLVNVIRQIFFRNKNEPPMVFHWVPFVGSTIS
YGMNPYKFFFSCREKYGDIYTFVMLGKKMTVYMGVKGNDFILNGKLKDLN
AEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKFGLSQSALESHVPLIE
KEVLDYIKTSPRFKGDSGVLDAPAAMAELTIYTAGSALQGKEVRKKLTAE
FADLFHDLEMGFTPINFILPWAPLPQNRKRDIAHARMRETYMEIINQRRK
NPDAQDHDMIWNLMHSTYKNGNPVPDKEIAHIMITLLMAGQHSSSSISAW
ILLRLASEPQILEELYQEQLANLKRDPRTGAFEPLQYKDLDLLPLHQNVI
KETLRVHLSIHSILRKVKNPIPVPDTPYIIPTSHTLLASPGATALSDEYF
PNANMWDPHRWENQRPDKEDEEGELIDYGYGAVSKRMSSPYLPFGGGRHR
CIGEKFAYVNLGVIVATIVRNLKLYNVDGKTGVPATDYSSMFMGPMKPAV
VGWERRFPARS*
CYP51F2 Magnaporthe grisea
AACU01001139 cont2.870
MG04628.4 (version4) 62% to CYP51 Penicillium
MAFFFPSAPVWVYSAGAALLFIIGSIILNFIWQQLPRPKSEPPLVFHWLP
FIGNAVSYGMDPYRFYSQCREKHGDVFTFVLFGRRMTVFLGVQGNDFILN
GKLQDLNAEEIYSPLTTPVFGSDIIYDCPNSKLMEQKKFVKFGLTQKALD
SYVPLIEREVLDYIESSPVFQAGNHGIVDIPSMMAEITIFTASRTLQGPE
VRKKLTGEFARLYHDLDLGFRPINFLAPWAPLPQNRRRDVAHARMRDVYM
DLINKRRRQKDDQEEEEEAEPDMIRHLMGSCVYKNGQALPDKEIAHMMIT
LLMAGQHSSSSSSAWIMLRLASRPDIAEEVYQEVQRLGHASLQHSDLDKL
PLLANVVKETLRVHSSIHSIMRKVKRPMRIPGSDYVVTPGKVLVSAPIMT
HLDEEHFRDARAWEPHRWDDAVDAQDDEIVDYGYGATSKGTKSPYLPFGA
GRHRCIGEKFAYLNLAAIVSTLVRNFKFSTLDGKATVPPTDYTSMFSRPM
QPATVRWERRSPKTA*
CYP51F2 Fusarium graminearum
AACM01000179 (WGS section)
FG04092.1 FGcontig1.179_scaffold2
60% to CYP51F1 Penicillium 68% to Mg CYP51F2 54% to Mg 51F1
MFHLLIYPLWVLVALFAVIIANLLYQQLPRRPDEPPLVFHWFPFFGNAVA
YGLDPCGFFEKCREKHGDVFTFILFGRKIVACLGVDGNDFVLNSRLQDAN
AEEVYGPLTIPVFGSDVVYDCPNSKLMEQKKFVKFGLTQKALESHVQLIE
REVLDYVETDPSFSGRTSTIDVPKAMAEITIFTASRSLQGEEVRRKLTAE
FAALYHDLDLGFRPVNFLFPWLPLPHNRKRDAAHIKMREVYMDIINDRRK
GGIRTEDGTDMIANLMGCTYKNGQPVPDKEIAHMMITLLMAGQHSSSSAS
SWIVLHLASSPDITEELYQEQLVNLSVNGALPPLQYSDLDKLPLLQNVVK
ETLRVHSSIHSILRKVKRPMQVPNSPYTITTDKVIMASPTVTAMSEEYFE
NAKTWNPHRWDNRAKEEVDTEDVIDYGYGAVSKGTKSPYLPFGAGRHRCI
GEKFAYVNLGVIVATLVRNFRLSTIDGRPGVPETDYTSLFSRPAQPAFIR
WERRKKI*
CYP51F2 Fusarium oxysporum
FOXG_11545
83% to CYP51F2 Fusarium graminearum
see fungal pages for seq
CYP51F2 Fusarium verticillioides
FVEG_10277
94% to CYP51F2 Fusarium oxysporum
see fungal pages for seq
CYP51F2 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_7000156
Necha1/scaffold_7:419968-421550
80% to Fusarium graminearum CYP51F2
57% to CYP51F1 like seq fgenesh1_pg.scaffold_2000426,
genome annotation in progress
Note only one intron, not two as seen in CYP51F1
MLLLVWYPVLAIGAFLGIILIHALRQKLFRKAGEPPLIFHWLPFIGNAVSYGLDPCNFFMKCREK (0)
HGDVFTFVLFGRKIVCCLGVEGNDFVLNSRLQDANAEEIYGPLTIPVFGSDVVYDCPNSKFMEQKKFVKFGLTQK
ALESHVQLIEREVLDYIHAVPAFSGSEGTVDISNAMAEITIFTAARSLQGEEVRRKLTAEFAALYHDLDL
GFKPVNFLFPWAPLPHNRKRDAAHAKMRDIYMDIINKRRAEGGDLGEYSDMIANLMGCTYKNGQPVPDKE
IAHMMITLLMAGQHSSSSASSWIMFRLASRPDIAEELYQEQLTHLSVDGYLPPLQHSDLDKLTLLQNVVK
ETLRVHSSIHSILRKVKTPMQAPGTQYTITTDKVILASPTVTALSEEYFSNARTWDPHRWDNKEKEEVAG
DDVVDYGYGKVSKGTKSPYLPFGAGRHRCIGEKFAYVNLGVIVATMVRNFKLSTMDGKSGVPATDYNSLF
SRPVQPAYIRWERRKA*
CYP51F2v1 Aspergillus fumigatus strain = ATCC 36607
GenEMBL AAF32372.1 also AAK73659.1
cytochrome P450 sterol 14 alpha-demethylase variant
MVPMLWLTAYMAVAVLTAILLNVVYQLFFRLWNRTEPPMVFHWVPFLGSTISYGIDPYKFFFACREKYGD
IFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLT
QSALESHVPLIEKEVLDYLRDSPNFQGSSGRMDISAAMAEITIFTAARALQGQEVRSKLTAEFADLYHDL
DKGFTPINFMLPWAPLPHNKKRDAAHARMRSIYVDIINQRRLDGDKDSQKSDMIWNLMNCTYKNGQQVPD
KEIAHMMITLLMAGQHSSSSISAWIMLRLASQPKVLEELYQEQLANLGPAGPDGSLPPLQYKDLDKLPFH
QHVIRETLRIHSSIHSIMRKVKSPLPVPGTPYMIPPGRVLLASPGVTALSDEHFPNAGCWDPHRWENQAT
KEQENDEVVDYGYGAVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVILATIVRHLRLFNVDGKKGVPETD
YSSLFSGPMKPSIIGWEKRSKNTSK
CYP51F2v2 Aspergillus fumigatus Af293
GenEMBL XP_752137.1 also EAL90099.1
14-alpha sterol demethylase variant
74% to 51F2 A. nidulans 62% to 51F1 A. nidulans
only 5 aa diffs to CYP51F2v1, may be a stran variant
MVPMLWLTAYMAVAVLTAILLNVVYQLFFRLWNRTEPPMVFHWVPYLGSTISYGIDPYKFFFACREKYGD
IFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLT
QSALESHVPLIEKEVLDYLRDSPNFQGSSGRVDISAAMAEITIFTAARALQGQEVRSKLTAEFADLYHDL
DKGFTPINFMLPWAPLPHNKKRDAAHARMRSIYVDIITQRRLDGEKDSQKSDMIWNLMNCTYKNGQQVPD
KEIAHMMITLLMAGQHSSSSISAWIMLRLASQPKVLEELYQEQLANLGPAGPDGSLPPLQYKDLDKLPFH
QHVIRETLRIHSSIHSIMRKVKSPLPVPGTPYMIPPGRVLLASPGVTALSDEHFPNAGCWDPHRWENQAT
KEQENDKVVDYGYGAVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVILATIVRHLRLFNVDGKKGVPETD
YSSLFSGPMKPSIIGWEKRSKNTSK
CYP51F2 Neosartorya fischeri NRRL 181
XM_001267337.1, NFIA_109350
97% to CYP51F2 Aspergillus fumigatus
MVPMLLLTAYMAVAMLTAILLNVVYQLFFRLWNRTEPPMVFHWV
PFLGSTISYGIDPYKFFFACREKYGDIFTFILLGQKTTVYLGVQGNEFILNGKLKDVN
AEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLTQSALESHVPLIEKEVLDYLR
NSPNFQGSSGQVDISAAMAEITIFTAARALQGQEVRSKLTAEFADLYHDLDKGFTPIN
FMLPWAPLPHNKKRDAAHARMRSIYIDIINQRRLDGEKDSQKSDMIWNLMNSTYKNGQ
QVPDKEIAHMMITLLMAGQHSSSSISAWIMLRLASQPKVLEELYQEQLANLGPVGPDG
SLPPLQYKDLDKLPFHQHVVRETLRLHSSIHSLMRKVKSPLPVPGTPYMIPPGRVLLA
SPGVTALSDEHFPNAGCWDPHRWENQAAKEQENDEVVDYGYGAVSKGTSSPYLPFGAG
RHRCIGEKFAYVNIGVILATIVRHLRLFNVDGKKGVPETDYSSLFSGPMKPSIIGWEK
RSKDTSK
CYP51F2 Aspergillus oryzae
GenEMBL BAE57417.1
77% to CYP51F4, 75% to CYP51F2 Aspergillus nidulans
MASFTLVSAYAAAGLLAIIVLNLLRQLLFRNKTDPPLVFHWIPFLGSTVTYGMDPYAFFFSCRQKYGDIF
TFILLGRKITVYLGIQGNEFILNGKLKDVNAEEIYSPLTTPVFGSDIVYDCPNSKLMEQKKFIKFGLTQA
ALESHVPLIEKEVLDYLKTSPNFKGTSGRVEITDAMAEITIFTAGRALQGEEVRKKLTTEFADLYHDLDR
GFTPINFMLPWAPLPRNRKRDAAHARMREIYMDIINERRKNPDRETSDMIWNLMHCTYKNGQPLPDKEIA
HMMITLLMAGQHSSSSISSWIMLRLASEPAVMEELYQEQITKLSPDGRTLPPLQYRDLDLLPLHQNLIKE
TLRLHLSIHSLMRKVKNPMPVPGTPYVVPADHVLLASPGVTALSDEYFPNASRWDPHRWENRVEKEDEED
IVDYGYGTVSKGTSSPYLPFGAGRHRCIGEKFAYVNLGVIVATMARHMKLFNVDGKKGVPATDYSSMFSG
PSKPAIIGWERRFPEKS
CYP51F2 Aspergillus flavus
AFL2G_02771
99% to CYP51F2 Aspergillus oryzae, 1 aa diff
see fungal pages for seq
CYP51F2 Aspergillus clavatus NRRL 1
XM_001271578.1, ACLA_046180
81% to CYP51F2 Aspergillus fumigatus
MLSLTLFGLYLVSATAVVILVNVVYQHLFRLRNRTEPPMVFHWI
PFIGSTITYGIDPCKFFFACREKYGNIFTFILLGQKVTVYLGVEGNEFILNGKLKDVN
AEEVYSPLTTPVFGSDVVYDCPNSKFMEQKKFIKFGLTQSALEAHVPLIEKEVLDYLE
TSPRFQGTSGLVDIAAAMAEITIFTAARALQGEEVRSKLTAEFADLYHDLDRCFTPVN
FMFPWAPLPRNKKRDAAHVRMRAIYVDIINQRRRDGGEDTQKSDMIWNLMNCSYKNGQ
QVPDKEIAHMMITLLMAGQHSSSSIGSWIMLRLASQPEVLEKLYQEQLDKLAQGGPGS
NLRPLQYKDLELLPYHQHVIRETLRLHSSIHSILRKVKNTLSVPGTSYVIPPGRVLLA
SPGVTALSDEHFPNASRWDPQRWENQTTKEDSGEMVDYGYGAVSKGTASPYLPFGAGR
HRCIGEKFAYVNIGVILATLVRHLRLSNMDGKEGVPATDYSSLFSGPMKPSIIQWGKR
SNDLSK
CYP51F2 Aspergillus terreus NIH2624
XM_001215095.1, ATEG_05917.1
78% to CYP51F2 Aspergillus fumigatus
MSLLTITSYAAVGILALIAWNVIRQLLFQNKSEPPVVFHWIPFL
GSTISYGIDPYAFFASCRQKYGDIFTFILLGQKTTVYLGVQGNEFILNGKLKDVNAEE
VYSPLTTPVFGSDVVYDCPNAKLMEQKKFIKYGLTQAALESHVQLIEREVLDYLRTSP
NFHGASGVVDISAAMAELTIFTAGRALQGEEVRRKLTAEFADLYHDLDKGFTPINFML
PWAPLPHNRKRDAAHARMRAIYMDIIRERRAHKNPDQVEAGSDSDMIWNLMRCTYKDG
QPVPDKEIAHMMITLLMAGQHSSSSISAWIFLRLASEPRVLEELYQEQVASLGKPDAD
GVFPPLQFRDLDRLPLHQNVVKETLRLHSSIHSIMRKVKNPLPVPGTPYVVPTSHVLL
ASPGVTATSDEYFPNASRWDPHRWENQAEPDDDGEMVDYGYGRVSKGTASPYLPFGGG
RHRCIGEKFAYINLGVIVATVVRHLKLANVDGRKGVPQTDYSSLFSGPVKPAIIGWER
RFPTA
CYP51F2 Aspergillus niger CBS 513.88
XM_001394187.1, CAK40582.1
80% to CYP51F2 Aspergillus fumigatus
MALLAVAGVYAFAALLVAIVLNVTRQLLFRNEKEPPVVFHWIPF
LGSTISYGMDPYTFFFSCRKKYGDIFTFVLLGQKTTVYLGVQGNDFILNGKLKDVSAE
EVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKFGLTQAALESHVQLIEKETLDYLRDS
PRFNGASGVIDIPAAMAEITIYTAARALQGEEVRKKLTAEFAELYHDLDKGFSPINFM
LPWAPLPHNQKRDAAHARMREIYTDIINERRKNPDEEKSDMIWNLMHCTYKSGQPVPD
KEIAHMMITLLMAGQHSSSSISSWIMLRLASEPQVLEELYQEQLASLSNRNGVFEPLQ
YQDLDKLPFLQSVIKETLRIHSSIHSIMRKVKNPLPVPGTSYIIPEDHVLLASPGVTA
LSDEYFPNATRWDPHRWENQPDKEEDGEMVDYGYGSVSKGTASPYLPFGAGRHRCIGE
KFAYVNLGVIIATIVRHLKLFNVDGRKGVPGTDYSTLFSGPMKPAIVGWERRFPDHSK
GSLN
CYP51F2 Aspergillus niger (from JGI)
estExt_fgenesh1_pm.C_40090|Aspni1
80% to CYP51F2 Aspergillus oryzae,
66% to 51F1 Penicillium italicum
4 aa diffs to Aspergillus niger CBS 513.88
MALLAVAGVYAFAALLVAIVLNVTRQLLFRNEKEPPVVFHWIPFLGSTISYGMDPYTFFFSCRKKYGDIFTFVLLGQKTT
VYLGVQGNDFILNGKLKDVSAEEVYSPLTTPVFGSDVVYDCPNSKLMEQKKFIKFGLTQAALESHVQLIEKETLDYLRDS
PRFNGASGVIDIPAAMAEITIYTAARALQGEEVRKKLTAEFAELYHDLDKGFSPINFMLPWAPLPHNRKRDAAHARMREI
YTDIINERRKNPDEEKSDMIWNLMHCTYKSGQPVPDKEIAHMMITLLMAGQHSSSSISSWIMLRLASEPQVLEELYQEQL
ASLSNRNGVFEPLQYQDLDKLPFLQSVIKETLRIHSSIHSIMRKVKNPLPVPGTSYIIPEDHVLLASPGVTALSDEYFPN
ATRWDPHRWENQPDKEEDGEMVDYGYGSVSKGTASPYLPFGAGRHRCIGEKFAYVNLGVIIATIVRHLKLFNVDGRKGVP
GTDYSTLFSGPMKPAIVGWERRFPDNIKGSMN*
CYP51F2 Ajellomyces capsulatus NAm1
XM_001540591.1
70% to CYP51F2 Aspergillus fumigatus
MSWFTIGTFGVLAFVAAVTLNLVYQLLFRFLNKTRPPLVFHWIP
FLGSTIRYRTDPYKFFFSCRQKEASRLFQHGDIFTFVLLGRPTTVYLGIKGNEFILNG
KLKDVNAEEVYGPLTTPVFGPDVVYDCPNSKLIEQKKFIKYGLTQAALESHVPLIEKE
VMDYLDSSPNFLGASGEVDISAVMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLDK
GFSPINFMLPWAPLPHNKKRDAAHTLMHAIYLDIIEKRRRAARNANGSQTQDMIENLM
QCTYKNGQKLPDKEIANIMISLLMAGQHSSSTTSSWIMLHLASEPAVVEQLYQEQLDN
LPRTGPNGSLGPLQYGDLNRLPLHRNVIRETLRLHTSIHSLLRKVMNPMPVAGTPYVI
PPSHVVLSAPGVTALSDEYFPNPTMWDPNRWETQEPKVDEKEDMVDYGYGTISKGTSS
PYLPFGAGRHRCIGEKFAYVNLTVIVAIMVRHLQFSNIGGKTGVPRTDYSSMFSAPMK
PARINWKRRTAKSG
CYP51F2 Histoplasma capsulatum G217B
94% to CYP51F2 Ajellomyces capsulatus NAm1
two identical sequences
ABBT01000205.1 Ajellomyces capsulatus G217B 481620-479996 (-)
ABBT01000207.1 Ajellomyces capsulatus G217B 78633-77009 (-)
HCB05685.1 identical to HCB06140.1
see fungal pages for seq
CYP51F2 Penicillium digitatum strain GL-01
DQ355161.1, also AJ439081 (5 aa diffs)
67% to CYP51F2 Aspergillus fumigatus
MDLVPLVTGQIKCIAYYTTGLVLASIVLNVIKQLVFYNRKEPPV
VFHWIPFIGSTVAYGMDPYQFFFASRAKYGNIFTFILLGKKTTVYLGVEGNEFILNGK
LKDVNAEEIYGKLTTPVFGSDVVYDCPNSKLMEQKKFIKYGLSQEALESYVPLIADEI
SSYIKSSPSFKGQSGTIDLVPAMAEITTFTAARTLQGEEVRSKLTTEFAKLFHDLDLG
FTPINFMLPWAPLPQNRKRDRAHRRMREIYVDIIQARREAGEEANDNGRDKTKGTDMI
SNLMRCVYRDGTPIPDKEIAHLMITLLMAGQHSSASISCWILLRLASQPEMTEKLFAE
QVNNLGADLPLLQYKDLDKLPLHRNVIKETLRLHSSIHTLMRKVKNPMPVPGTDFVIP
PSHTLLSSPGVTARDERHFRDPLRWDPHRWGSRVEAEDSSDTVDYRYGAVSKGTRSPY
LPFGAGRHRCIGEKFAYLNLGVIIATLLREFRFFNPEGMEGVPDTDYSSLFSRPMQPA
TVRWEVRS
CYP51F2 Metarhizium anisopliae var. acridum Ma102
CYP51F2 Metarhizium anisopliae var. anisopliae Ma23
CYP51F3 Fusarium graminearum
AACM01000457 (WGS section)
FG11024.1 FGcontig1.457_scaffold8
50% to 51F1 N.crassa (third CYP51 in this genome)
MESLYETLRTLPLSVSIPLTTSIIIILSIVTNVVKQLWFPNPHRPPVVFH
IFPFIGSTVQYGIDPYAFFFDCRDKYGDCFTFILLGKSTTVFLGPKGNDF
ILNGKHADLNAEDVYGKLTTPVFGEEVVYDCSNARFMDQKRLLKLGLTTD
SLRCYIPKFVKEVEDYVKNSPYFKGDTGIVNITEVMAEITIYTASGSLLG
NEVRSMFDSTFATLYRHLDDGFQPINFVMPGLPLPQNFRRNHARKVMEKL
FSDIISKRRETGNQGDETDMIWMLMNAQYKDGEPLPDHHAARMLIAILMG
GQHNTAVSGAWLLLNLAHKPHLVQELYEEQTQVLGSPQEPLTWENLQKLT
LNGQVIKETLRLHSPIHSILRQVKSPMRVPGTEWVVPPSHTLLSSPGTMA
RSEEFFPRPSEWDPHRWDKIEPLVKTAEDGQTVDYGFGVMSKSVSSPYLP
FGAGRHRCVGENYAYAQLGAIVATFIRLVHIEQPDPKAPLPAPDYSSMFS
RPMNPAEIRWRRRETVE*
CYP51F3 Fusarium oxysporum
FOXG_13138
87% to CYP51F3 Fusarium graminearum
note: gc boundary at DQKR
see fungal pages for seq
CYP51F3 Fusarium verticillioides
FVEG_12391
95% to CYP51F3 Fusarium oxysporum
see fungal pages for seq
CYP51F3 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_6000765
Necha1/scaffold_6:2267196-2268844
81% to Fusarium graminearum CYP51F3
52% to fgenesh1_pg.scaffold_2000426,
Note two exons, but the second exon is not seen in CYP51F1 or CYP51F2
MESLYGSFRALPLSISIPFTVGLVVVIAIARNVIGQLYFPDRNRPPVVFHVFPFIGSSVQYGIDPYKFFF
DCKAKYGDCFTFILLGKPTTVFLGQKGNEFILNGKHADLNAEEVYGKLTTPVFGKEVVYDCSNARFMDQKR (0)
LLKLGLTTEALRAYIPKFVKEVEDYVNTSPYFKGETGQVNITEVMAEITIYTASGSLLGNEVRSMFDST
FALLYRHLDDGFQPINFVMPWLPLPQNRRRDHARNVMEGLFANIIRQRREQGNQGDETDMIWTLMDAQYK
DGTVLPDIHVARLLIAILMGGQHNTAASGAWLFLNLAHKPHLVEEMYQEQLEVLGSPPAPLTWENVQKLT
LNGQVIKETLRLHSPIHSIMREVKSPMPVPGTEWVVPPSHTLLASPGTLARSEDFFPRPLEWDPHRWDKA
DPVEGPVDDSQKVDYGFGMMSKAVSSPYLPFGAGRHRCVGEHYAYAQLGAIVATFVRLCHMEQVDPKAPI
PATDYS (1)
SMFSRPMNPAVIKWRRRKPE*
CYP51F4 Aspergillus oryzae
GenEMBL BAE63554.1
72% to 51F2 Aspergillus nidulans, 77% to 51F2 Aspergillus oryzae
60% to 51F1 Aspergillus oryzae
MSWPRIGAYALLAFVAIMALNVTYQFLFRMLNKTRPPLVFHWIPFIGSTIHYGTDPYGFFFSCREKYGDI
FTFILLGRPTTVYLGTQGNEFILNGKLKDVNAEEVYSPLTTPVFGSDVVYDCPNSKLIEQKKFIKFGLSQ
AALEAHVPLIEKEVEDYLAMSPNFHGTSGEVDIPAAMAEITIFTAGSALQGEEVRSKLTTEFAVLYHDLD
KGFTPINFMLPWAPLPHNKKRDAAHARMRAIYIDIINKRRNAGDNVPEKLDMIGNLMQCTYKNGQPLPDK
EIAHIMITLLMAGQHSSSSISSWIMLRLASQPAVVEELYQEQLANLERTGPNGSLAPLQYKDFDNLPLHQ
NVIRETLRLHSSIHSLLRKVKNPLPVPGTPYVIPTSHVLLAAPGVTALSDEYFPNAMAWDPHRWETQAPQ
ENNKDDIVDYGYGAMSKGTSSPYLPFGAGRHRCIGEKFAYLNLAVIVATMVRHLRFSNLDGQTGVPDTDY
SSLFSGPMKPARIRWERRAAKSG
CYP51F5 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
RO3G_16595.1
62% to CYP51F1 Rhizopus oryzae
42% to CYP51F1 Ustilago maydis in the CYP51 family
45% to CYP51F1 S. pombe
see fungal pages for seq
CYP51F6 Kluyveromyces polysporus
Kpol_1023p61
65% to CYP51F1 S. cerevisiae
see fungal pages for seq
CYP51F7 Uncinocarpus reesii
UREG_00593.1
58% to CYP51F Uncinocarpus reesii from PPVV on
62% to Aspergillus terreus CYP51F1
model is short. Seq. runs into a gap, missing last exon
see fungal pages for seq
CYP51F7 Coccidioides immitis
CIMG_00573.2
84% to CYP51F7 Uncinocarpus reesii
(ortholog to second CYP51 in this species)
CIMG_00573.2
CYP51F8 confidential basidiomycete
CYP51G1 Triticum aestivum (wheat)
Francis Durst
CYP51BLE
submitted to nomenclature committee
note: CYP51G subfamily is for Green plants and their close relatives
see under plants for more 51G sequences
CYP51H1 Oryza sativa (rice)
note: the CYP51H subfamily is for non-typical CYP51s in Green plants
and their close relatives see under plants for more 51H sequences
52A Subfamily
CYP52A1 Candida tropicalis
GenEMBL M24894 M15945
Sanglard,D. and Loper,J.C.
Characterization of the alkane-inducible cytochrome P450 (P450alk)
gene from the yeast Candida tropicalis: identification of a new
P450 gene family.
Gene 76, 121-136 (1989)
CYP52A2 Candida tropicalis
Swiss P30607 (522 amino acids) GenEMBL M63258 (5745bp)
Seghezzi,W., Sanglard,D. and Fiechter,A.
Characterization of a second alkane-inducible cytochrome
P450p-encoding gene, CYP52A2, from Candida tropicalis
Gene 106, 51-60 (1991)
CYP52A3 Candida maltosa
GenEMBL D12475 D01168 (2047bp)
Ohkuma,M., Hijiki,T., Tanimoto,T., Schunck,W.H., Muller,H.G.,
Yano,K. and Takagi,M.
Evidence that more than one gene encodes n-alkane-inducible
cytochrome P-450s in Candida maltosa, found by two-step gene
disruption.
Agric. Biol. Chem. 55, 1757-1764 (1991)
Note: This is CYP52A3-b, one of two alleles in C. maltosa.
CYP52A3 Candida maltosa
GenEMBL S77461 (2047bp) Swiss P24458 (523 amino acids)
Ohkuma,M., Hikiji,T., Tanimoto,T., Schunck,W.H., Muller,H.G.,
Yano,K. and Takagi,M.
Evidence that more than one gene encodes n-alkane-inducible
cytochrome P-450s in Candida maltosa, found by two-step gene
disruption
Agric. Biol. Chem. 55, 1757-1764 (1991)
CYP52A4 Candida maltosa
GenEMBL X51932, S64322 (1787bp)
Schunck,W.H., Vogel,F., Gross,B., Kargel,E., Mauersberger,S.,
Kopke,K., Gengnagel,C. and Muller,H.G.
Comparison of two cytochromes P-450 from Candida maltosa:
primary structures, substrate specificities and effects of
their expression in Saccharomyces cerevisiae on the proliferation
of the endoplasmic reticulum.
Eur. J. Cell Biol. 55, 336-345 (1991)
CYP52A5 Candida maltosa
GenEMBL D12714
Ohkuma,M.
GenEMBL X55881
Ohkuma,M., Muraoka,S., Tanimoto,T., Fujii,M., Ohta,A. and Takagi,M.
CYP52 (cytochrome P450alk) multigene family in Candida maltosa:
identification and characterization of eight members.
DNA Cell Biol. 14, 163-173 (1995)
CYP52A6 Candida tropicalis
GenEMBL Z13010 (2501bp) Swiss P30608 (524 amino acids)
Seghezzi,W., Meili,C., Ruffiner,R., Kuenzi,R., Sanglard,D. and
Fiechter,A.
Identification and characterization of additional members of the
cytochrome P450 gene family CYP52 of Candida tropicalis.
DNA Cell Biol. 11, 767-780 (1992)
CYP52A7 Candida tropicalis
GenEMBL Z13011 (2087bp) Swiss P30609 (507 amino acids)
Seghezzi,W., Meili,C., Ruffiner,R., Kuenzi,R., Sanglard,D. and
Fiechter,A.
Identification and characterization of additional members of the
cytochrome P450 gene family CYP52 of Candida tropicalis.
DNA Cell Biol. 11, 767-780 (1992)
CYP52A8 Candida tropicalis
GenEMBL Z13012 (1929bp) Swiss P30610 (517 amino acids)
Seghezzi,W., Meili,C., Ruffiner,R., Kuenzi,R., Sanglard,D. and
Fiechter,A.
Identification and characterization of additional members of the
cytochrome P450 gene family CYP52 of Candida tropicalis.
DNA Cell Biol. 11, 767-780 (1992)
CYP52A9 Candida maltosa
GenEMBL D26160 (283bp)
Ohkuma,M.
unpublished
ALK5-B allele of CYP52A9 ALK5-A
CYP52A9 Candida maltosa
PIR JS0723
ALK5-A
CYP52A10 Candida maltosa
CYP52A11 Candida maltosa
GenEMBL D26159 (815bp)
Ohkuma,M.
unpublished
ALK8-B allele of CYP52A11 ALK8-A
Note on CYP52A12-CYP52A20 and CYP52D2 from Candida tropicalis.
These sequences seem to be orthologs of other Candida tropicalis sequences.
52A12 seems to be an ortholog of 52A6
52A13 and 52A14 seem to be orthologs of 52A2
52A15 and 52A16 seem to be orthologs of 52A1
52A17 and 52A18 seem top be orthologs of 52A8
52A19 and 52A20 seem to be orthologs of 52A7
the last 8 listed appear in what might be allelic pairs 94-96% identical to each other.
It seems probable that these actually are the orthologs of those other sequences
and this Candida tropicalis strain is different from the other.
CYP52D2 matches Candida maltosa 52D1 and was not observed in C. tropicalis before.
CYP52A12 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 1p
90% to CYP52A6
CYP52A13 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 2p might be an allele of CYP52A14 (96% identical)
86% to CYP52A2
CYP52A14 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 3p might be an allele of CYP52A13 (96% identical)
87% to CYP52A2
CYP52A15 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 4p might be an allele of CYP52A16 (95% identical)
85% to CYP52A1
CYP52A16 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 5p might be an allele of CYP52A15 (95% identical)
84% to CYP52A1
CYP52A17 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 7p might be an allele of CYP52A18 (94% identical)
78% to CYP52A8
CYP52A18 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 8p might be an allele of CYP52A17 (94% identical)
77% to CYP52A8
CYP52A19 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 9p might be an allele of CYP52A20 (95% identical)
75% to CYP52A7
CYP52A20 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 10p might be an allele of CYP52A19 (95% identical)
76% to CYP52A7
CYP52A21 Candida albicans
GenEMBL XM_705082 (one aa diff to the Kim seq), orf19_10
XM_705076 (one aa diff to the Kim seq)
Y14766 (3 aa diffs to the Kim seq)
Donghak Kim and Paul Ortiz de Montellano
Submitted to nomenclature committee July 21, 2006
72% to CYP52A11 (ALK8) of Candida maltosa
CYP52A22 Candida albicans SC5314
79% to CYP52A4 orf19_7512
see Fungal pages for seq
CYP52A23 Candida albicans SC5314
78% to CYP52A5 orf19_7513
see Fungal pages for seq
CYP52A24 Candida albicans SC5314
78% to CYP52A3 orf19_5728 partial sequence
see Fungal pages for seq
CYP52A25 Candida dublinensis
cdub_593-g99.1
79% to CYP52A3 Candida maltosa
see Fungal pages for seq
CYP52A26 Candida dublinensis
cdub_14-g136.1
89% to CYP52A21 Candida albicans
see Fungal pages for seq
CYP52A27 Candida dublinensis
cdub_14-g720.1
94% to CYP52A23 Candida albicans
see Fungal pages for seq
CYP52A28 Candida dublinensis
cdub_14-g719.1
93% to CYP52A22 Candida albicans
see Fungal pages for seq
CYP52A29 Candida lusitaniae
CLUG_03984.1
55% to CYP52A13 Candida tropicalis
see Fungal pages for seq
CYP52A30 Candida lusitaniae
CLUG_04851.1
55% to CYP52A23 Candida albicans
see Fungal pages for seq
CYP52A31 Candida lusitaniae
CLUG_04098.1
52% to CYP52A18 Candida tropicalis
see Fungal pages for seq
CYP52A32 Candida parapsilosis
CPAG_03577
71% to CYP52A5 Candida maltosa
see Fungal pages for seq
CYP52A33 Candida parapsilosis
CPAG_04394
73% to CYP52A5 Candida maltosa
see Fungal pages for seq
CYP52A34 Candida parapsilosis
CPAG_04395
71% to CYP52A5 Candida maltosa
see Fungal pages for seq
CYP52A35 Candida parapsilosis
CPAG_05481
65% to CYP52A21 Candida albicans
see Fungal pages for seq
CYP52A36 Candida parapsilosis
CPAG_05482
65% to CYP52A21 Candida albicans
see Fungal pages for seq
CYP52A37 Candida parapsilosis
CPAG_05523
58% to CYP52A12 Candida tropicalis
see Fungal pages for seq
CYP52A38 Candida parapsilosis
CPAG_02285
74% to CYP52A25 Candida dublinensis
see Fungal pages for seq
CYP52A39 Candida guilliermondii
PGUG_01238.1
66% to CYP52A14 Candida tropicalis
see Fungal pages for seq
CYP52A40 Candida guilliermondii
PGUG_05855.1
60% to CYP52A25 Candida dublinensis
see Fungal pages for seq
CYP52A41 Candida guilliermondii
PGUG_04005.1
52% to CYP52A12 Candida tropicalis
see Fungal pages for seq
CYP52A42 Candida guilliermondii
PGUG_05670.1
62% to CYP52A23 Candida albicans
see Fungal pages for seq
CYP52A43 Debaryomyces hansenii
CAG85755.1
54% to CYP52A3 Candida maltosa
see Fungal pages for seq
CYP52A44 Debaryomyces hansenii
CAG85832.1
63% to CYP52A25 Candida dublinensis
see Fungal pages for seq
CYP52A45 Debaryomyces hansenii
CAG88380.1
62% to CYP52A14 Candida tropicalis
see Fungal pages for seq
CYP52A46 Debaryomyces hansenii
CAG88381.1
63% to CYP52A14 Candida tropicalis
see Fungal pages for seq
CYP52A47 Debaryomyces hansenii
CAG88382.1
65% to CYP52A14 Candida tropicalis
see Fungal pages for seq
CYP52A48 Lodderomyces elongisporus
LELG_04957
73% to CYP52A38 Candida parapsilosis
see Fungal pages for seq
CYP52A49 Lodderomyces elongisporus
LELG_03506
72% to CYP52A37 Candida parapsilosis
see Fungal pages for seq
CYP52A50 Lodderomyces elongisporus
LELG_03505
71% to CYP52A37 Candida parapsilosis
see Fungal pages for seq
CYP52A51 Lodderomyces elongisporus
LELG_03309
75% to CYP52A35 Candida parapsilosis
see Fungal pages for seq
CYP52A52 Lodderomyces elongisporus
LELG_00044
70% to CYP52A5 Candida maltosa
see Fungal pages for seq
CYP52A53 Pichia stipitis
JGI model e_gww1.3.1.449.1
65% to CYP52A40 Candida guilliermondii
see Fungal pages for seq
CYP52A54 Pichia stipitis
JGI model e_gww1.3.1.459.1
63% to CYP52A44 Debaryomyces hansenii
see Fungal pages for seq
CYP52A55 Pichia stipitis
JGI model fgenesh1_pm.C_chr_3.1000237
63% to CYP52A14 Candida tropicalis
see Fungal pages for seq
CYP52A56 Pichia stipitis
JGI model fgenesh1_pm.C_chr_8.1000042
59% to CYP52A38 Candida parapsilosis
see Fungal pages for seq
CYP52A57 Pichia stipitis
JGI model e_gww1.3.1.1392.1
62% to CYP52A39 Candida guilliermondii
see Fungal pages for seq
52B Subfamily
CYP52B1 Candida tropicalis
GenEMBL Z13013 (2442bp) Swiss P30611 (506 amino acids)
Seghezzi,W., Meili,C., Ruffiner,R., Kuenzi,R., Sanglard,D. and
Fiechter,A.
Identification and characterization of additional members of the
cytochrome P450 gene family CYP52 of Candida tropicalis.
DNA Cell Biol. 11, 767-780 (1992)
52C Subfamily
CYP52C1 Candida tropicalis
GenEMBL Z13014 (1622bp) Swiss P30612 (505 amino acids)
Seghezzi,W., Meili,C., Ruffiner,R., Kuenzi,R., Sanglard,D. and
Fiechter,A.
Identification and characterization of additional members of the
cytochrome P450 gene family CYP52 of Candida tropicalis.
DNA Cell Biol. 11, 767-780 (1992)
CYP52C2 Candida maltosa
D12718
CYP52C3 Candida albicans SC5314
60% to CYP52C2 orf19_6574
see Fungal pages for seq
CYP52C4 Candida dublinensis
cdub_588-g100.1
94% to CYP52C3 Candida albicans (ortholog)
see Fungal pages for seq
CYP52C5 Candida parapsilosis
CPAG_01250
48% to CYP52C3 Candida albican
There is one 52C seq per Candida species except this
species has two. They all seem to be orthologs even
though the percent identity is not high
see Fungal pages for seq
CYP52C6 Candida parapsilosis
CPAG_01665
50% to CYP52C2 Candida maltosa
53% to to CYP52C5 this species
see Fungal pages for seq
CYP52C7 Lodderomyces elongisporus
LELG_05768
54% to CYP52C6 Candida parapsilosis
48% to CYP52C3 Candida albicans
see Fungal pages for seq
52D Subfamily
CYP52D1 Candida maltosa
CYP52D2 Candida tropicalis
No accession number
David Craft Cognis Corp.
Submitted to nomenclature committee June 26, 2001
Clone name 6p
61% to CYP52D1
52E Subfamily
CYP52E1 Candida apicola
GenEMBL X76225 (1560bp) PIR S38894 (519 amino acids)
Lottermoser,K.
unpublished (1994)
CYP52E2 Candida apicola
GenEMBL X87640 (2203bp)
Lottermoser,K., Schunck,W.H. and Asperger,O.
Cytochromes P450 of the sophorose lipid-producing yeast Candida
apicola: heterogeneity and polymerase chain reaction-mediated
cloning of two genes
Yeast 12 (6), 565-575 (1996)
CYP52E3 Candida bombicola, alternative name Starmerella bombicola
EU552420
Inge Van Bogaert
Submitted to nomenclature committee Dec. 7, 2007
Gene2
92% to 52E2, 82% to 52E1
CYP52E4 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
86% to CYP52E1
CYP52E5 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
86% to CYP52E1
CYP52E6 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
86% to CYP52E1
52F Subfamily
CYP52F1 Yarrowia lipolytica
GenEMBL AB010388 (3578bp), GenPept CAG80007.1
Iida,T., Ohta,A. and Takagi,M.
Cloning and characterization of an n-alkane-inducible cytochrome
P450 gene essential for n-decane assimilation by Yarrowia
lipolytica.
Yeast 14 (15), 1387-1397 (1998)
gene for ALK1
see Fungal pages for seq
CYP52F2 Yarrowia lipolytica gene for ALK2
GenEMBL AB010389, GenPept CAG77659.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F3 Yarrowia lipolytica gene for ALK3
GenEMBL AB010390, GenPept CAG79910.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F4 Yarrowia lipolytica gene for ALK4
GenEMBL AB010391, GenPept CAG83106.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F5 Yarrowia lipolytica gene for ALK5
GenEMBL AB010392, GenPept CAG83107.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F6 Yarrowia lipolytica gene for ALK6
GenEMBL AB010393, GenPept CAG82620.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F7 Yarrowia lipolytica gene for ALK7
GenEMBL AB010394, GenPept CAG84028.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F8 Yarrowia lipolytica gene for ALK8
GenEMBL AB010395, GenPept CAG82058.1
Iida,T., Ohta,A. and Takagi,M.
Yarrowia lipolytica cytochrome P450 gene, complete cds
unpublished
see Fungal pages for seq
CYP52F9 Yarrowia lipolytica
CAG84211.1
64% to CYP52F3
see Fungal pages for seq
CYP52F10 Yarrowia lipolytica
CAG82791.1
71% to CYP52F1
see Fungal pages for seq
CYP52F11 Yarrowia lipolytica
CAG83401.1
69% to CYP52F2
see Fungal pages for seq
CYP52G1 Aspergillus nidulans
AN6057.1
38% to 539A1 46% to 52F1 52 clan
see Fungal pages for seq
CYP52G2 Aspergillus fumigatus Af293
GenEMBL XP_755288.1 also EAL93250.1
60% to 52G1
MGLPLLTIAAVAVALRLLWTLAARWQHAQNARRLGCGSIPLYPSDPLGISVLKETLAADKAKKLLPLVER
RVALMSDREGRYVTTFRFRQMGRENYFTTDPKNIQAILATQFKDFELGAPRRQALHPLLGAGIFSSDGEE
WFHARGLLRPQFTRDQISDLDLEERHVQKAMQAMPVVNGKWTDAVDIQSIFFRLTIDSATEFLFGESVES
QLSALNGGQTPVDTFPYYFDKSQWYAAQRARFEKLYWIVNNKECRHAQNEVHAYVDRVVHKALKAAREGK
LANPNKPSQYVFLHALVSVTQDPIELRSQLLNILLAGRDTTASLLSWTVLMLARHPAEFHKLRQTIVDEF
GTYDQPRNITFAALKSCQYLQYCLNETLRLFPVVPGNRRSATRDTTLPRGGGSDGTQPIYIRKGQTVVYN
VHILHRRKDIWGPDAEEFKPSRWVDRKVGWDYVPFNGGPRICIGQQFALTEAGYVLVRLLQRFDAIEDMQ
PHLEIRHSLNLTSAPADNVTVRLREAA
CYP52G2 Neosartorya fischeri
NFIA_085030
97% to CYP52G2 Aspergillus fumigatus = ortholog
see Fungal pages for seq
CYP52G3 Aspergillus oryzae
GenEMBL BAE65166.1, AP007171.1
58% to CYP52G4, 63% to 52G1
14 P450 genes and 2 pseudogenes on this contig
MIPLLILAALAVVFRLVWSIFTSLRHAQNARKWHCGAIPTYPGDILGINTLKEVLRADKEKLIPVLSAQR
VETMTAREGRYVSTFRLRQMGRESIFTSDPKNMQAILATQFKEFELGSLRRNSLHPLLGSGIFSTDGEAW
SRSRSLLRPQFTRDQVSDLDLEERHVQKAMAGMLADPATKWTPEIDIQSIFFRLTIDSATEFLFGDSVES
QTAALSGSRIIEDKFPSYFDRGQWYAAQRARFEKLYWIVNNKESRETDRFVHAYVDRFIDAALAAVKEGK
IDPEKRNSDHYVFLHGLTTATQDPVELRSQLLNILLAGRDTTASLLSWCVLLLARHPDIFQKLRNTILAD
FGDYRNPRNITFSSLKSCRYLHYFMNEVLRLYPIVPGNRRVALKDTTLPRGGGPDGSEPVYVRKGQPVVY
SVFVTHRRKDIWGADAEVFNPDRWEDLKVGWEYLPFNGGPRICIGQQFALTEAGYVLVRLLQRFDQIVDA
RPEREIRFNATLTSAPWENVIVRLREGA
CYP52G3 Aspergillus flavus
AFL2G_05445
99% to CYP52G3 Aspergillus oryzae
see Fungal pages for seq
CYP52G4 Aspergillus oryzae
GenEMBL BAE55312.1
54% to 52G1
MSDARTTLMETWFTPALVAAIVAARLLFSLYSAWRHAQRARSLNCQEAPLYPSRDPFGVATLLETLRADR
DKFLPKLSQKRVDLISSQQNRYVSTFRVRQAGRENFFTVDPKNIQAMLATQFNDFFLGDMRRNAGAPVIR
SGIFVSDGADWSHSRSLIRPQFTRTQINNLELEERHVQNALRAMPTQSNGWTSEVDIQTILFRLTLDSAT
EFLFGKSCNSQLTALEKDAGEMSDSFLNSFDRCAWYLAARLRFERLYWIVNNKEFRECTRVVHELVDGYV
HAALQRAQQAEKPADPERGSHYVFVDALTATTQDPNQLRDECLNVLIAGCDTTASLLSWNILLLARHPDI
FQRLRKEIIERFGTYSEPRDINFSSLKSCQYLQHFINETLRLHPVVPFNRRCANKDTTLPRGGGKDGNSP
VYLQKGQPVLYSSYVLQRRKDIWGEDAEEFNPDRWYGRKAIWEHIPFSGGPRTCIGQQFAITNTSFVLVR
LLQRFDSIEDVYPEREIRYGVTLTNCPADRVTVRMHQAEL
CYP52G4 Aspergillus flavus
99% to CYP52G4 Aspergillus oryzae
AFL2G_00228
see Fungal pages for seq
CYP52G5P Nectria haematococca
e_gw1.8.757.1
Necha1/scaffold_8:999970-1000262
old name = CYP-un1 pseudogene
PSEUDOGENE very short piece
57% to 538A3, 54% to 584D1, 61% to 52A3, 68% to 52G2
DESLRLYPVEPINARYANKDTTLPRGGGKDGNSPILIPKGSSTAFSVHIIHRRKDIRGPD
ANEFKPERWEGRRVGWEYVP ()
FNGGPRICIG**FALIGASYVTVRLLQRFDKMESLEKDAVVRHNLKLINYVANGVKVRLHAAS
CYP52G6 Aspergillus niger
fgenesh1_pg.C_scaffold_15000225|Aspni1
57% to CYP52G2
see Fungal pages for seq
CYP52G7 Aspergillus niger
e_gw1.7.657.1|Aspni1
67% to CYP52G3
see Fungal pages for seq
CYP52G8 Aspergillus clavatus
ACLA_081330
83% to CYP52G2
see Fungal pages for seq
CYP52G9 Aspergillus terreus NIH2624
GenPept EAU33222.1
ATEG_06678
CH476602
complement(join(1144551..1145711,1145779..1146177))
62% to CYP52G2
see Fungal pages for seq
CYP52G10 Aspergillus terreus
ATEG_07540.1
68% to CYP52G4
see Fungal pages for seq
CYP52G11 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-4
66% TO CYP52G6 Aspergillus niger, 56% TO CYP52G2 Aspergillus fumigatus
CYP52H1 Aspergillus nidulans
AN7131.1
45% to 584B1 52 clan
see Fungal pages for seq
CYP52H2 Aspergillus fumigatus Af293
GenEMBL XP_746567.1 also EAL84529.1
cytochrome P450 alkane hydroxylase
72% to 52H1
MLAPAVALFAAVYTTFLVLRYFQQLYKHRKQARSLRCQPPADGEAGFLGIASFLRLRKAAKEKRWIELIA
EQYGKYGNTFTQTIFGQPLVSTIEPENLKALLATQFNDFELGTRHREFYPLLGDGIFTLDGAGWSHARAL
LRPQFTRDQVADLDLMDGHVSRLIDLVPKDGSAFDIQRLFFLLTIDSATHFLFGESVGSLHAGTDTGLLG
RSAVGNAEGFAEAFNKAQEYLAARSRAVVFYWMINPKEFRDANKRVHEVVDHYVQLALESRRNPEKKQPG
GRYIFAEALAAENDNPKVLRDNMLNILLAGRDTTASLLSSTFFYLARHPNVWIKLRQVIVDAFGDAEHPK
EEITQTKLKDIPYLRYVLNEVLRLLPPVPANFRVANKDTTLPVGGGPDQKSPVYIRKGTIVTYSVYAMHR
RTDFYGPDANEFRPERWEENGKRGWEYLPFNGGPRICLGQQYALTEASFTIVKLLQRFDRIENGDPDLIE
PIQQTNLTLAHDRGVYIRLYSSKAL
CYP52H2 Neosartorya fischeri
NFIA_029600
95% to CYP52H2 Aspergillus fumigatus = ortholog
see Fungal pages for seq
CYP52H3 Aspergillus oryzae
GenEMBL BAE64862.1, AP007171.1
71% to 52H1, 48% to 584G1
14 P450 genes and 2 pseudogenes on this contig
MLAQIAPLFGALCITFLVLQYLQRLYQQRKRAQSLGCQPAAQGPSGIFGIRSFVRLLNEVRHKRWVEYIA
GQYGRYGNTYTQKALGKWMVSTIEPENIKALLATQFNDFGLGTRHREFYPLLGDGIFTLDGPGWSHARGL
LRPQFTRDQVADLELMDGHISRMIDLIPQDGSSFDIQRLFFLLTIDSATHFLFGESVGALESSNSASLLG
RSSVGSAQGFAEAFGTAQDYLTTRSRAMHFYWMVNPKEFREANQRVHEVVDHYVQLAIQSKNNPDKKSDR
YIFAEALAADNDDPKVLRDNMLNILVAGRDTTASLLSSAFFYLSRNQDVWKKLRQTIIDEFGDSQNPKGE
ITQAKLKDIPYLRYVLNEVLRLLPPVPLNFRVAAKDTSLPVGGGPDGRSPVFIPKGQVVAYSVYAMHRRT
DLYGPDSHSFRPERWEENGRRGWDYLPFNGGPRICLGQQYALTEASYTLVKLVQRFDTLECADPELKQPA
ILSTLTMSHDRGVKVRLSSSVPKCWFNQ
CYP52H3 Aspergillus flavus
AFL2G_05134
100% to CYP52H3 Aspergillus oryzae
see Fungal pages for seq
CYP52H4 Aspergillus niger
estExt_GeneWisePlus.C_80246|Aspni1
73% to CYP52H2
see Fungal pages for seq
CYP52H5 Aspergillus clavatus
ACLA_054640
84% to CYP52H2 Aspergillus fumigatus
see Fungal pages for seq
CYP52H6 Aspergillus terreus
ATEG_02198.1
75% to CYP52H5
see Fungal pages for seq
CYP52J1P Aspergillus fumigatus Af293
GenEMBL XP_746816.1 also EAL84778.1
alkane hydroxylase predicted
42% to CYP52F1, in 52 clan
insertion of 11 C bases causes frameshift = &
MTNTDIAFGHQHGCELPPELTKNWPLGLDRIKELWTANTEGHLLAFLCSVAEKYEPGNSITQYFLFGPRA
FHILQPESVEAILSTNFKDYGFGARAAIFAPRLGNGIFTQEGPAWRHSRDLLRKQFSRVQNRILEHFHEH
VDNMVARLPLDGVVDLQPLFFNLTLDIATALLFGRSVYSLLAGIDQDADNGLFAEGFNIAQDGLAKRFRI
APWHFLYNPPGFRKACGDVHRFVEQYIDQLDLENSEDLDDKTYGFIKRVAHESASRQHLRDQLLNVLLAG
RDTTACCLSWTFRLLVHHEQAMIRLREEIASVMGDSAHPTKEQIRKMPYLSCVIKE
SLRLYPPP &
PPVPLNNREAIRTTILPTGGGPDADRPILVRKGELVVFFQYVNSRKKNIYGPDADCFRP
ERWETGELDHIGWAYFPFNGGPRQCLGENFALMEVSYTVVRLLQTFSSIILPKGQPIEPVGSERQRLTLV
LSSADGCKVQIHS
CYP52J1 Neosartorya fischeri
NFIA_113870
95% to CYP52J1 Aspergillus fumigatus = ortholog
see Fungal pages for seq
CYP52J2 Uncinocarpus reesii
UREG_00942.1
71% to 52J1 in overlapping parts
see Fungal pages for seq
CYP52K1 Aspergillus oryzae
GenEMBL BAE66393.1
44% to 52A5, 44% TO CYP52J1
MLTLSFSALLGIALAWAIHRLAWKYSRLKAICVKRDNKLATQYGCEQPPRLRNWWPLGIDRLIQIWTADS
EQRLMDLFTFPFKDVGYTLEQKFLGTIAFGTIDPENLEAIMTNINVFSFGLRRHILFPLLGDGIFTQEGK
SWRHSRELLRPQFTRQHYRDLNIFRPHVDRLLHYLTGNGAATDLQPLFFRLTLDTTTEYLFGKSVNSLMP
GEATKGQSFANHFDMAQNYVVQRFRLLDLYWLIGGPKFWRSCSAVHRFIDEIIDTRMDSKEKDKDCNSKS
IFFDAVARDSRTRRDLRDQLTNVLLAGRDTTACLLSWTFHCLARHPDVLGRLNVEIASVVGTNTDLTRDD
FKRMPYLDQVLREVLRLYPPVPVNTRTAHKTTILPTGGGKDGTKPFMVREGENVAFCVYAMHRREDLYGP
DAGQFRPERWDEDLPLFQNERTATWGYLPFNGGPRACLGQDFGFVEAAYTVVRILQKYPIVKPDMYKGDI
QGRKWLGWSSHQPEGIEMVTEERQKMTIVLSLGDGCRVTLGR
CYP52K1P Aspergillus flavus
AFL2G_11704
97% to CYP52K1 Aspergillus oryzae
small 6 aa deletion and frameshift = &
see Fungal pages for seq
CYP52L1 Graphium sp. ATCC 58400
GenEMBL AY438638.1
Skinner,K.M., Cone,M. and Ciuffetti,L.M.
Characterization and cloning of an alkane inducible cytochrome P450
monooxygenase from a filamentous fungi, Graphium sp.
Unpublished
alkane monooxygenase P-450 (ALK1) gene
41/65 top blast hits to a complete set of named fungal P450s
are CYP52 sequences. The others are from CYP538, CYP539, CYP584, CYP585
related families in the CYP52 clan of fungal P450s.
45% to CYP52G2 Aspergillus fumigatus
MMDPFYLLGGCCVFGIVYKSVATLYVNYVHGKTARELGCKPLPK
ERTRFFGLDILRREMKADREMYLPSDIMTRFEEVGATTYEYQMLNEKHIATCDPLVIQ
TVLATQFKEFTFGNRPWGTVLGNGIFSIDNIGDNKEWLHTRAMLKPQFLRNQVSDLEL
EEGHVRNFMSVLKVGDDGWTPKVNLQHMFFNFTLDSATEFLFGKSADCQLLFAPGGDP
KGVSKPLRAFLKALDVAKETVNTKWFLGNNGWIADSPTFRKNCAYVNDFMDALIAKTK
AELEAKPKGSKPSGGREKYHFLHAMLDETDDKVELRGQALNILLAGRETTASLLGWLW
YYLARHPIEFQKLRAAVLKDFGTAENPKPMSFESLKACDQLQYCNNEILRLFPLVSYN
SRMALTDTTLPRGGGPDGNSPIFVKKGQQIVYHPHAMHRRKDIWGQDADEFRPDRWKT
LRPGWEYIPFNGGGRICMGQQFALTEASYLTVRLLQRFDRIENLDPNPVLKQKFRIVN
TPGEGVLVRLHEAAAGA
CYP52M1 Candida bombicola alternative name Starmerella bombicola
EU552419
Inge Van Bogaert
Submitted to nomenclature committee Dec. 7, 2007
gene1
45% to CYP52A3, 45% to CYP52E1
CYP52N1 Candida bombicola alternative name Starmerella bombicola
EU552421
Inge Van Bogaert
Submitted to nomenclature committee Dec. 7, 2007
Gene3
45% to CYP52M1, 45% to CYP52A15
CYP52N2 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
94% to CYP52N3, 85% to CYP52N1
CYP52N3 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
94% to CYP52N2, 85% to CYP52N1
CYP52P1 Aspergillus niger
gw1.4.1682.1|Aspni1
46% to CYP52K1
see Fungal pages for seq
CYP52P2 Mycosphaerella graminicola
Mgr076
53% to CYP52P1 A. niger, 47% to 52K1 (missing N-term)
yellow from JGI model e_gw1.8.895.1|Mycgr3
see Fungal pages for seq
CYP52P3 Metarhizium anisopliae var. acridum Ma102
CYP52Q1 Aspergillus niger
e_gw1.11.186.1|Aspni1
45% to CYP52H3, 41% to CYP52P1
see Fungal pages for seq
CYP52R1 Mycosphaerella graminicola
Mgr006
51% to CYP52G2 Aspergillus fumigatus
see Fungal pages for seq
CYP52R2 Mycosphaerella fijiensis
fgenesh1_pm.C_scaffold_45000005
60% to CYP52R1 Mycosphaerella graminicola
see Fungal pages for seq
CYP52S1 Yarrowia lipolytica
CAG81974.1
42% to 52H3, 44% to 52F1
see Fungal pages for seq
CYP52T1 Aspergillus terreus
ATEG_03903.1
48% to CYP52G2
see Fungal pages for seq
CYP52V1X Metarhizium anisopliae
No accession number
Confidential
Renamed CYP52X2
CYP52U1 Metarhizium anisopliae var. acridum Ma102
No accession number
Confidential
CYP52W1 Metarhizium anisopliae var. acridum Ma102
No accession number
Confidential
CYP52X1 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-1
48% to CYP52R1 Mycosphaerella graminicola
50% to CYP52G2 Neosartorya fischeri
60% to CYP52X2
CYP52X2 Metarhizium anisopliae var. acridum Ma102
No accession number
Confidential
CYP52X2 Metarhizium anisopliae var. anisopliae Ma23
CYP52X3 Trichodherma harzianum (anamorph) Hypocrea lixii (teleomorph)
No accession number
Renata Del Carratore
Submitted to nomenclature committee July 13, 2010
65% to CYP52X2 Metarhizium anisopliae
47% to CYP52R1 Mycosphaerella graminicola
49% to CYP52G2 Neosartorya fischeri NFIA_085030
53A Subfamily
CYP53A1 Aspergillus niger
GenEMBL X52521
van Gorcom,R.F., Boschloo,J.G., Kuijvenhoven,A., Lange,J., van
Vark,A.J., Bos,C.J., van Balken,J.A., Pouwels,P.H. and van den
Hondel,C.A.
Isolation and molecular characterisation of the
benzoate-para-hydroxylase gene (bphA) of Aspergillus niger: a
member of a new gene family of the cytochrome P450 superfamily
Mol. Gen. Genet. 223, 192-197 (1990)
CYP53A2 Aspergillus parasiticus
GenEMBL AC005991
Lewis,J., Kupfer,D., Keller,N. and Roe,B.A.
Aspergillus parasiticus Cosmid Clone ap0
Unpublished
57% to CYP53A3
27896 MLLDLYLVKCLFCPL
27941 VPIVALGLLVAYYVAGYLKQWHLHDLPGPFIAGFSRIWLILQVRQGYRSLVVNDLHRRCG 28120
28121 KIVRLAPNHISVADESAIQAIYGHGNGFLK 28210 intron
28267 SNFYNAFLNVDWSIFTTRSRAEHTRKRKIVSHAFSARSLAQVEQYAHNTMELLVRQWQ 28440
28441 KMVDSQEGLDDPYAVIDARVWCNYLTFDIIGDLAFGAPFGMLERGNAIVSMRKALEDAAV 28620
28621 TLDAVEVLNHRGDVSAALGICPDLIPYAKWLPDLFFRQGAEAIANVADVAGAAVDRRLKM 28800
28801 NTSMTEKRGDLLAHLIDAEDQAGAKLGYRELTGEAVTLIAAGSDTSSSTLCALLYWVSTT 28980
28981 PRVLWKLQNVLDEVIPVDVEVPYLAMVKKI 29070 intron
29117 PSLQWVIWEALRIHSTFGQGLPREVPPERGPVEICSHTFYPGDVLSVPGYTMHHSVDIWG 29296
29297 IDVEDFVPERWDPCRLTQRQKDSFIPFSEGPRACIGRNLAEMEFFVGCATLFRLFEFRVE 29476
29477 GQGPLEVREGWLRKPVSLQVGIRRRYLDVRSS* 29575
CYP53A3 Aspergillus nidulans or Emericella nidulans
GenEMBL AY048583, AN7589.1
Fraser,J.A., Davis,M.A. and Hynes,M.J.
Submitted to nomenclature committee Oct. 3, 2000
benzoate-para-hydroxylase (bzuA) gene
82% identical to CYP53A1
MITDFLTPENITPERIALALLGLLAAYYVVPYLQTWRLSDIPAP
GLAAWTNFWLLLQTRLGHRFISVDNAHKKYGKLVRIAPRHISIADDAAIQAVYGHGNG
FLKSDFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSAKSIGQFEQYIHHNIENLVK
QLTRISNLQRNPKNGYATVDALNWFNFVAFDIIGDLAFGAPFGMLDKGQDIAEMRKSP
DSPPQYVQAVEVLNRRGEVSATLGCYPALKPFAKYLPDRFFRDGLEAVENLAGIAIAC
VNERLKPEVMANNTRVDLLARLMEGKDANGNKLGRAELTAEALTQLIAGSDTTSNTSC
AILYYCLRTPGVIDKLHKVLDEAIPQDVEVPTHAMVKEIPYLQWVIWETMRIHSTSAM
GLPREIPEGNPPVEISGHIFKPGDILSVPTYTIHHSKEIWGADADEFIPERWAPERLT
ARQKAAFIPFSTGPRACVGRNVAEMELLVICSTVFRMFDWELQQKGPMETREGFLRKP
LGLTVGVKRRTIV
CYP53A4 Neurospora crassa
AABX01000266.1 cont3.41 NCU01086.1 (version3)
9a61.tfa_50cg@9A61
65% to 53A1 over 417 aa
note the automated assembly of the gene is missing the KYG
fragment seen in 53A1. See my assembly for corrected seq.
Neurospora crassa sequence contig 1.248 (supercontig 26)
14619 MAIISLLMSPWAPVVLLAGVAFYYLVPYFVTYSALRKIPSPFPAQFTDLWLL
SVCRRGNRYQRVDELHKKLGPVVRIQPNHVSICDDAAIPTIYGHGNGF
LNDFYDAFVSIRRGLFNTRDRAEHTRKRKIVSHTFSAKSVQQFEPYMHSNLELFVKQWDSMIKNSKNPDKAAHLD
CLEWFNYLAFDVIGDLSFGQPFGMLSSGADMAEIRSSPDAAPIYAPAIEILNRRGEVSATLGIHPALKPFAKYLP
DPFFTKGLAAVENLAGIAIACVKSRLDNPPPVTRKDLLQRLMEGRDEKGEPLGREELTAEALTQLIAGSDTTSNS
SCALLFHAVRTPGVMQKLQAELDANIPPEVDVPTYDMVKELPYLEAVINEVLRFHSTSGIGLPRQIPHDASQGVH
IQGYYLPPGTVLSVPTYSIHHSKEIWGPDADEFKPERWERLTARQKNAFIPFSHGPRSCVGRNVAEMEMKLIVAT
WARRYEVKLLQDYMDTREGFLRKPLGLKVGLKLRK 13029
CYP53A4 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_10226
97% to CYP53A4 N. crassa
see Fungal pages for seq
CYP53A5 Magnaporthe grisea
MG07977.4
AACU01000984.1 cont2.1481 runs off end, changed C-term
AACU01000983 cont2.1480 = N-term
69% to CYP53A4 (split on two contigs)
see Fungal pages for seq
CYP53A6 Fusarium graminearum
FG08079.1 AACM01000324 FGcontig1.324_scaffold5
see Fungal pages for seq
CYP53A7 Fusarium graminearum
FG08086.1 AACM01000324 FGcontig1.324_scaffold5
see Fungal pages for seq
CYP53A8 Fusarium graminearum
FG10451.1 AACM01000435 FGcontig1.435_scaffold7
see Fungal pages for seq
CYP53A10 Nectria haematococca (Fusarium solani group)
83% to Fusarium graminearum CYP53A7 possible ortholog
fgenesh1_pg.scaffold_37000003
Necha1/scaffold_37:6771-8451
59% to fgenesh1_pg.scaffold_12000228,
Note: this seq has two more introns than the CYP53A8 ortholog
This gene model seems correct DRN 2/4/06
see Fungal pages for seq
CYP53A11 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_12000228
Necha1/scaffold_12:587439-589032
84% to Fusarium graminearum CYP53A8 possible ortholog
64% TO 53A1 Aspergillus niger
This gene model seems correct DRN 2/4/06
see Fungal pages for seq
CYP53A12 Aspergillus fumigatus Af293
GenEMBL XP_755858.1 also EAL93820.1
join(<2165575..2165876,2165928..2166734,
2166796..>2167246)
benzoate 4-monooxygenase
85% to CYP53A1, 79% to 53A3 seq looks correct
MITDLLSLQNAGLILLGLIAVYYVIPYLQKWHLHDIPSPRFAAFSNLWLLLQARRGRRFLKVDEAHKKYG
KLVRIAPKHVSIADDAAIQAIYGHGNGFLKADFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSMKSIG
QFEQYIHQNVELFVQQWTKLAKLNGNPRSGYATIDALNWFNYLAFDIIGDLAFGAPFGMLEKGKDIAEMR
KTPDSEPTYVQAVEVLNRRGEVSATLGCLPRLIPYAKYLPDRFFKDGVQAVENLAGIAVARVNERLKPEV
MEKNTRVDLLSRLMEGKDSNGNKLGREELTAEALTQLIAGSDTTSNTTCAILYWCMSTPGVIPKLQKVLD
EAIPDDVDVPTHAMVKDIPYLQWVIWETMRIHSTSAMGLPREIPPGNPPVTISGHTFYPGDVVSVPSYTI
HRSKEIWGPDAEKFVPERWDPARLTARQKAAFIPFSTGPRACVGRNVAEMELLVMTGTIFRLFEFEMQQD
GPMETREGFLRKPLGLIVGMKRRAVHASV
CYP53A12 Neosartorya fischeri
NFIA_090480
96% to CYP53A12 Aspergillus fumigatus = ortholog
see Fungal pages for seq
CYP53A13 Aspergillus oryzae
GenEMBL BAE60506.1
58% TO CYP53A14, 81% to 53A3
MIAELLTPTGAAYVLTAAVIVYYILPYLQLWRLRDIPSPGFAAFSNLWLMLQYRKGNRFVTVDNAHKKYG
KLVRIAPRHVSIADDEAIQAIYGHGNGFLKADFYDAFVSIRRGLFNTRDRAEHTRKRKTVSHTFSMKSIG
QFEQYIHGNAELFVKQWNRIADTQSNPKTGYATIDALNWFNYLAFDIIGDLAFGAPFGMLEKGQDIAEMR
KSPNDKPSYVQAVEVLNRRGEVSATLGACPSLIPWAKYIPDRFFRDGLEAVENLAGIAVARVNERLRPEV
MANNTRVDLLARLMEGKDSNGNKLGREELTAEALTQLIAGSDTTSNTSCAILYWCLRTPGVIEKLHKVLD
ESIPKDVDVPVHAMVKDIPYLQWVIWETMRIHSTSAMGLPREIPAGNPPVTISGHTFYPGDVVSVPTYTI
HRSKEIWGPDAEQFVPERWDPKRLTARQKAAFIPFSTGPRACVGRNVAEMELLVIVGTVFRLFDFEIQQD
GPMETREGFLRKPLGLMVGMKRRSVAV
CYP53A13 Aspergillus flavus
AFL2G_03223
99% to CYP53A13 Aspergillus oryzae,
1 aa diff, N-term extension deleted
see Fungal pages for seq
CYP53A14 Aspergillus oryzae
BAE56637.1
56% to 53A3
MDGDSCPSCCSTCTSLNVFLCPHIPILTLGLLLVYYVTGYLKRWHLRDIPGPFIAGFSRIWLIVQVRQGY
RSLVVHDLHRRYGKIVRLAPNHISIADESAIQAIYGHGNGFLETDFYNAFLNVDWSIFTTRSRAEHTRKR
KIVSHAFSARSLAQVEQHAHNNMEHLVRQWRKMIDSEEGLDDPYAVIDARVWCNYLTFDIIGDLAFGAPF
GMLERENATVSMRKAPENPEVTLDAVEVLNHRGDVSAAFGICPDLIPYAKWLPDPFFRQGAEAIANLAGV
AGAAVDRRLKMDTSMTEKRGDLLALLIDAEDQAGAKLGHRELTGEAVTLIAAGSDTSSSTLCALLYWVSS
TPRVLWKLQNVLDEVIPVDIEVPYLAMVKKITYLQWVIWEALRIHSTFGQGLPREVPPERGPVEICGHTF
YPGDVLSVPGYTMHHSADIWGIDVEDFVPERWDPRRLTQRQKDSFIPFSEGPRACIGRNLAEMELFVGCA
TLFRLFEFRVEGQGPLKVRERWLRKPVSLQVGIRRRYLDARSS
CYP53A15 Cochliobolus lunatus
EU597483
Nada Krasevec
Submitted to nomenclature committee July 10, 2007
65% to CYP53A1
CYP53A16 Mycosphaerella graminicola
Mgr055
64% to CYP53A11 Nectria haematococca
see Fungal pages for seq
CYP53A17 Uncinocarpus reesii
UREG_05168.1
74% to CYP53A1 Aspergillus niger
model has some missing seq (added back)
see Fungal pages for seq
CYP53A18 Coccidioides immitis
CIMG_09108.2
90% to CYP53A17
see Fungal pages for seq
CYP53A19 Fusarium oxysporum
FOXG_04952
90% to CYP53A8
see Fungal pages for seq
CYP53A19 Fusarium verticillioides
FVEG_03183
98% to CYP53A19 Fusarium oxysporum = ortholog
see Fungal pages for seq
CYP53A20 Fusarium oxysporum
FOXG_02776
92% to CYP53A7
see Fungal pages for seq
CYP53A20 Fusarium verticillioides
FVEG_01611
97% to CYP53A20 Fusarium oxysporum = ortholog
see Fungal pages for seq
CYP53A21 Aspergillus clavatus
ACLA_074210
90% to CYP53A12
see Fungal pages for seq
CYP53A22 Aspergillus terreus
ATEG_07877.1
85% to CYP53A12
see Fungal pages for seq
CYP53A23 Mycosphaerella fijiensis
estExt_fgenesh1_pm.C_10348
88% to CYP53A16 Mgr055 Mycosphaerella graminicola
see Fungal pages for seq
CYP53A24 Metarhizium anisopliae var. anisopliae Ma23
CYP52A25 Metarhizium anisopliae var. acridum Ma102
CYP53A25 Metarhizium anisopliae var. anisopliae Ma23
CYP53A26 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-7
76% TO CYP53A11 Nectria haematococca
CYP53A27 Grosmannia clavigera
53B Subfamily
CYP53B1 Rhodotorula minuta (a fungi)
GenEMBL D63703(2766bp)
Fukuda,H., Nakamura,K., Shibuya,K., Tanase,S., Gotoh,O., Ogawa,T.
and Fujii,T.
Nucleotide sequence of gene for cytochrome P450rm from Rhodotorula
minuta IFO 1102.
Unpublished (1995)
CYP53B2 Sporobolomyces roseus
estExt_fgenesh1_pg.C_30339
57% to CYP53B1 Rhodotorula minuta
see Fungal pages for seq
CYP53B3 Puccinia graminis f. sp. Tritici
PGTG_08085 + PGTG_08086 revised
54% to CYP53B2 from LNRYP
see Fungal pages for seq
CYP53C1 Ustilago maydis
GenEMBL XM_397620.1
hypothetical protein UM00005.1
in the CYP53 clan part B 54% to 53A1 54% to 53B1
CYP53C2 Phanerochaete chrysosporium
AY321584
55% to CYP53C1
my Scaffold_164a
JGI gene models ug.1.19.1 and pc.1.261.1
MAVIEALTQLDLKSWLLLIPALAIVAHILVWLLDPHGIRSYPGP
LLAKFSDAWLGYVAAQGHRSEVVHDLHKQYGTFVRIAPNHLSIADPDALQVVYGHGTG
TLKSNFYDAFVSIQRGLFNTRSRSEHARKRKIVSHIFSQKSVLEFEPHVRLYVKQLIQ
QWDRLYEAGAKGLSGDDGEGGWRGRNGRVWLDCLPWYNYLAFDIIGDLAFGAPFGMLL
AARDAAPVAVDHEQAMASYGKEKSEVQYIPAVQVINDRGTYSASLGVLPPWMRPIVKL
FPWFRRGQKAVKQLAGIAVAAVAQRLTTPTDRVDLLGKLQEGRDDDGNLMGKEELTAE
ALTQLIAGSDTTSNSSCAITYYLAKYPDAQRKLQQELDEALGSDDEPVSTFDQVKRLP
YLQAVIDEALRIHSTSGIGLPRLVPKGGMTVCGRFFPEGTVLSVPTYTIHRDEEVWGK
DPEVFRPERWFEQDKNAVQKTYNPFSFGPRSCIGRNLANMELLIIVSSILRRYDFVLE
DPDKPFDTMEGFLRKPVECVVGIRRRTL
CYP53C3 Postia placenta (brown rot basidiomycete fungi)
CYP53C4 confidential basidiomycete
CYP53D1 Postia placenta (brown rot basidiomycete fungi)
CYP53D2v1 Postia placenta (brown rot basidiomycete fungi)
CYP53D2v2 Postia placenta (brown rot basidiomycete fungi)
CYP53D3 Postia placenta (brown rot basidiomycete fungi)
CYP53D4 Postia placenta (brown rot basidiomycete fungi)
CYP53D5 Postia placenta (brown rot basidiomycete fungi)
CYP53D6 Postia placenta (brown rot basidiomycete fungi)
CYP53D1X Fusarium oxysporum
FOXG_14732
48% to CYP53A10
see Fungal pages for seq
renamed CYP53F1 due to name conflict
CYP53E1 Grosmannia clavigera
CYP53F1 Fusarium oxysporum
FOXG_14732
48% to CYP53A10
see Fungal pages for seq
formerly CYP53D1
54A Subfamily
CYP54A1 Neurospora crassa
GenEMBL X15033
Neurospora crassa sequence contig 1.1450 (supercontig 261)
The translation below is more accurate than the one in Genbank
MALTQLAHSASALLPLVLPSIAAILAFAIFQRYFAPNPLSNLPIVGEEYHGYEKKRQAYLTKAKDLYLEGYTKFKHGLFRIVTPNR
NSVIVVSPRFLDELKKLPDDVVSFDAANDDSMHTKYTLIPTHEPILPHTIKTSLTPSLPRLNPQLSEEVQAFSQEIAPLMSSSPSD
WAPININSKLLRIVAKVSGRVFIGPELCHDERYLEAAVGYTVSVMEAQRAVERMNPWVRPIAAWRLKEVRKLAQMERDATAFLRPV
VEARREKQRKGEEKDNDMLQWLMDSADQGQGKQHGKWGEDTTTTRKLARLQLAISFAAIHTTTLVTTHAVYSLAADPKLQATLREE
IQSVLQEHKGVFNTSALQAMKKTDSFLKETMRFHPLGQTSFNRKVLRTFALSNGQVIPKGSTIEVPNYAVSRDPEAYPNPDVPDPL
RFYNLRNEAREKGEAEQGASGQFVSVNKEFLTFGYGRHACPGRFFAANEIKMILANLVMTYEMGLVEGETERYRDWDIAAGTIPDP
TKDVMFRKL*
CYP54A1 Neurospora discreta
JGI gene model scaffold_13-snap.17.1
93% to CYP54A N. crassa
see Fungal pages for seq
CYP54B1 Magnaporthe grisea
MG01391.4
45% to CYP54A1 AACU01000043 cont2.256
AI068604 revised to fill in gap
see Fungal pages for seq
CYP54C1 Fusarium graminearum
FG11536.1 AACM01000473 FGcontig1.473_scaffold10
see Fungal pages for seq
CYP54C2 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_20000135
Necha1/scaffold_20:362069-363960
75% to Fusarium graminearum CYP54C1 probable ortholog
small gap after GYQK? (5 aa), this seq looks right,
maybe the 54C seq is too long here.
Note LTIEQ can be removed from 54C and
the intron boundary is preserved.
This gene model seems correct
see Fungal pages for seq
CYP54C3 Cryphonectria parasitica
CB690595.1 60% to CYP54C2 N-term only, 55% TO 54C1
MATSTTSSLSETLSERFLVIVAAVLACALAYLGPKIISIIRLAALPVIGTE
LGNEEKRRQAYLQGARKLYYAAYDNFKNGLFKGAARLTTSRNANVIVVSPKFLPELNKLP
DSVVSMEAAVDDAMETKYTKIESHVPIIPHTVTGKLTPSLTRLNPTIARETAEALEL
EMPLREFTNWQEVNIHEKLLRIVGMXSGR
CYP54C4 Cryphonectria parasitica
CB686707.1 CB688482.1
55% TO CYP54C1
TRPMPTCEDWTAVKINSVLLRIVAKASGRIFVGPELCHSEEYLEAAIRYTVEVIGAANAV
SNVPPWLRSFKASKLPEVQRLHERRKHAIKFMQPVVESRKDLDQKPDDLLQWLIDNEGNL
GDMSTWKLARTQLALSFAAIHTSTVVSTNVFYTLAVMPNEVILELRDEIRSVLGENNGNFT
SSALQSMKKVDSFIKETMRYYPFANHSFERKVMRTFTLSNGQVIPAGVILECSTAHNQDD
EVFPDASRFDPWRFSKLQEQEKEDGMDGAARHQMVSVTPNHLTFGYGRHACPGRFFAINX
IKMIIGTFLLNYDIKNIDGVK*
CYP54C5 Fusarium oxysporum
FOXG_01238
82% to CYP54C1
see Fungal pages for seq
CYP54C5 Fusarium verticillioides
FVEG_00258 revised
90% to CYP54C5 Fusarium oxysporum = ortholog
see Fungal pages for seq
CYP54C6 Metarhizium anisopliae var. anisopliae Ma23
55A Subfamily
CYP55A1 Fusarium oxysporum
GenEMBL D14517 (2598bp)
Tomura,D., Obika,K., Fukamizu,A. and Shoun,H.
Nitric oxide reductase cytochrome P450 (P450nor) gene,
CYP 55, of the fungus Fusarium oxysporum containing a
putative FNR site in its upstream flanking region.
unpublished (1993)
CYP55A1 Fusarium oxysporum
PIR A40401 (403 amino acids)
Kizawa, H., Tomura, D., Oda, M., Fukamizu, A., Hoshino, T.,
Gotoh, O., Yasui, T., Shoun, H.
Nucleotide sequence of the unique nitrate/nitrite-inducible
cytochrome P-450 cDNA from Fusarium oxysporum.
J. Biol. Chem. 266, 10632-10637 (1991)
Note: This sequence is probably a bacterial sequence related to the
105
family.
CYP55A1 Fusarium oxysporum
GenEMBL D14517 (2598bp)
Park, S.-Y., Shimizu, H., Adachi, S.-i., Nakagawa,A.,
Tanaka, I., Nakahara, K.,
Shoun, H., Obayashi, E., Nakamura, H., Iizuka, T. and Shiro, Y.
Crystal structure of nitric oxide reductase from dentrifying fungus
Fusarium oxysporum.
Nature Structural Biology 4, 827-832 (1997)
CYP55A1v2 Fusarium oxysporum
FOXG_12350
96% to CYP55A1v1
see Fungal pages for seq
CYP55A1 Fusarium verticillioides
FVEG_10773
96% to CYP55A1v2 Fusarium oxysporum
see Fungal pages for seq
CYP55A2 Cylindrocarpon tonkinense (a denitrifying fungus)
GenEMBL D78511
Shoun,H.
nor1
CYP55A3 Cylindrocarpon tonkinense (a denitrifying fungus)
GenEMBL D78512
Shoun,H.
nor2
CYP55A4 Trichosporon cutaneum (a basidiomycete fungus)
GenEMBL AB052733
Zhang,L., Takaya,N., Kitazume,T., Kondo,T. and Shoun,H.
Purification and cDNA cloning of nitric oxide reductase cytochrome
P450nor (CYP55A4) from Trichosporon cutaneum
Eur. J. Biochem. 268 (11), 3198-3204 (2001)
Submitted to nomenclature committee Oct. 11, 2000
P450nor
66% to CYP55A1
CYP55A5v1 Aspergillus oryzae
GenEMBL AB055659
Kaya,M., Hata,Y., Kawato,A., Abe,Y. and Akita,O.
Aspergillus oryzae CYP55A5 gene for cytochrome P450nor
Submitted to nomenclature committee Jan. 23, 2001
60% to 55A1
CYP55A5v1 Aspergillus oryzae
GenEMBL BAC01275.1
cytochrome P450nor
MNSEPVYPRFPFARPSGDEPPAEFHRLLRECPVSRVELWDGSHPWLVVKHKDVCEVLTDPRLSKVRQRDG
FPEMSPGGKAAARNRPTFVDMDAPDHMHQRSMVSAFFNDEYVESRLPFIRDTVQHYLDRLIRAGKDGKEV
DLVKHFALPIPSHIIYDILGIPIEDFEYLSGCDATRTNGSSTAAAAQAANKEILEYLERLVDKKTTNPSH
DVISTLVIQQLKPGHIEKLDVVQIAFLLLVAGNATVVSMIALGVVTLLEHPDQLSRLLEDPSLSNLFVEE
LCRFHTASALATRRVATVDIELRGQKIRAGEGIIASNQAANRDPEVFPDPDTFDMFRKRGPEEALGFGYG
DHRCIAEMLARAELETVFSTLFQTLPSLKLAIPKSEIQWTPPTRDVGIVGLPVTWDRD
CYP55A5v2 Aspergillus oryzae
GenEMBL BAE61721.1
6 aa diffs to CYP55A5v1
MQLEPVYPRFPFARPSGDEPPAEFHRLLRECPVSRVELWDGSHPWLVVKHKDVCEVLTDPRLSKVRQRDG
FPEMSPGGKAAARNRPTFVDMDAPDHMHQRSMVSAFFNDAYVESRLPFIRDTVQYYLDRLIRAGEDGKEV
DLVKHFALPIPSHIIYDILGIPIEDFEYLSGCDATRTNGSSTAAAAQAANKEILEYLERLVDKKTTNPSH
DVISTLVIQQLKPGHIEKLDVVQIAFLLLVAGNATVVSMIALGVVTLLEHPDQLSRLLEDPSLSNLFVEE
LCRFHTASALATRRVATVDIELRGQKIRAGEGIIASNQAANRDPEVFPDPDTFDMFRKRGPEEALGFGYG
DHRCIAEMLARAELETVFSTLFQTLPSLKLAVPKSEIQWTPPTRDVGIVGLPVTWDRD
CYP55A5 Aspergillus flavus
AFL2G_09432
99% to CYP55A5v2 Aspergillus oryzae, 2 aa diffs
Supercontig 11: 146268-147914 (-) strand
see Fungal pages for seq
CYP55A6 Neurospora crassa
AABX01000354.1 cont3.356 NCU06137.1 (version3)
Neurospora crassa sequence contig 1.183 (supercontig 22)
1c8.tfa_90cg@1C8
70% to CYP55A1
EST h8b02ne.f1 in lower case
mgaltenlefpfrrasgldpppeyawlrktdpvtqvrlfdgslawlvtkyhdvCQVATDERLSKERTRPGFPELA
AGGKEAAKNRATFVDMDPPKHMQYRGMVQPIFEMEHVKELEPYIQKTVDDLLERMKNMGCEGGPVDLVQNFALPVPSY (?)
IIYTILGVPVEDLDFLTQQNSIRTNGSSTAREASAANQ (?)
ELLNYLRRLAEQRLQEPKDDLISKLMTEQVKAGKLDTADAVQMAFLLLVAGNATMVNMIAL (0)
GIVTLFLNPSQLEELKRDPSVVPAFVEELSRFHTASAMAIRRVAKEDL
EIRGKTIKKGEGVIASNLSANRDEEVFKDADKFDMHREWPVKELGFGWGEHRCIAEFLAKAELKAVF (?)
ETIFKKLPDLKIAVPFDEIEYTPLDRDVGIVKLPVTW
CYP55A6 Neurospora discreta
JGI gene model estExt_fgenesh3_pm.C_80311
95% to CYP55A6 N. crassa
see Fungal pages for seq
CYP55A7 Trichosporon domesticus SBUG 752 (a basidiomycete fungus)
GenEMBL AY044231 and AY044232
Dirk Patzak
Submitted to nomenclature committee March 4, 2002
124 amino acid N-terminal fragment
77% to 55A4
CYP55A8 Fusarium graminearum
FG11585.1 AACM01000475.1 FGcontig1.475_scaffold11
see Fungal pages for seq
CYP55A9 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_30000098
Necha1/scaffold_30:272059-273639
92% to CYP55A2 Cylindrocarpon tonkinense probable ortholog
genome annotation in progress
79% to CYP55A8 Fusarium graminearum
This gene model seems correct DRN 2/5/06
see Fungal pages for seq
CYP55A10 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_28000090 [Necha1:94366]
Necha1/scaffold_28:245547-247185
96% to CYP55A3 Cylindrocarpon tonkinense probable ortholog
genome annotation in progress
Note: the very high similarity suggests a very close
relationship between the two species. This is higher
than the ortholog pair matches between
F. graminearum and N. haematococca
This seq is originally of bacterial origin (P450 B type
not E type) similar to CYP105s
This gene model seems correct DRN 2/4/06
see Fungal pages for seq
CYP55A11 Nectria haematococca (Fusarium solani group)
estExt_fgenesh1_pg.C_880004 (better model)
Necha1/scaffold_88:11555-13495
58% to CYP55A3 Cylindrocarpon tonkinense
69% to AB226066.1 Aspergillus oryzae cDNA
58% to fgenesh1_pg.scaffold_28000090
54% to CYP55A8 Fusarium graminearum
same as fgenesh1_pg.scaffold_88000004 which is too long at
SNAQAHPAP between MHQ and RQM
Note: This gene has one extra intron at the N-terminal
that only codes for 3 amino acids
This gene model seems correct DRN 2/5/06
see Fungal pages for seq
CYP55A12P Aspergillus niger
gw1.11.1089.1|Aspni1
48% to CYP55A5v1 aa 53-257, this is a pseudogene
see Fungal pages for seq
CYP55A13 Uncinocarpus reesii
UREG_06342.1
71% to CYP55A5v1 Aspergillus oryzae
see Fungal pages for seq
CYP55A14 Histoplasma capsulatum
HCB04560.1
73% to CYP55A13
see Fungal pages for seq
CYP55A15P Fusarium oxysporum
FOXG_14888
74% to CYP55A2 Cylindrocarpon tonkinense
see Fungal pages for seq
CYP55A16P Fusarium oxysporum
FOXG_17502
83% to CYP55A11
see Fungal pages for seq
CYP55A17 Aspergillus terreus
ATEG_06140.1
73% to CYP55A13 Uncinocarpus reesii
see Fungal pages for seq
CYP55A18 Trichophyton rubrum
ESTs DW700172.1, DW689200.1, DW681558.1
72% to CYP55A14 Histoplasma capsulatum
see Fungal pages for seq
CYP55A19 Metarhizium anisopliae var. acridum Ma102
CYP55A19 Metarhizium anisopliae var. anisopliae Ma23
CYP55A20 Metarhizium anisopliae var. acridum Ma102
CYP55A20 Metarhizium anisopliae var. anisopliae Ma23
CYP55B1 Chlamydomonas reinhardtii (green algae)
See Chlamydomonas pages
CYP55C1 Aspergillus niger
fgenesh1_pm.C_scaffold_5000072|Aspni1
40% to CYP55A1, 40% to CYP55B1
see Fungal pages for seq
56A Subfamily
CYP56A1 Saccharomyces cerevisiae
GenEMBL X55713(2265bp) PIR S13502 (489 amino acids)
Briza, P., Breitenbach, M., Ellinger, A. and Segall, J.
Isolation of two developmentally regulated genes involved in
spore wall maturation in Saccharomyces cerevisiae.
Genes Dev. 4, 1775-1789 (1990)
CYP56A2 Saccharomyces paradoxus NRRL Y-17217
GenEMBL AABY01000059.1
91% to CYP56A1
46799 MELFKLLGLTLFLTISYIAFAIIVPPLNFPKNIPTIPFYVVFLPVVFPIDQTELYDLYIR 46620
46619 ESMEKYGAVKFFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVI 46440
46439 SAHGAVWRDYRNAVTNGLQHFDDTPIFKNAKLLCTLIKRRLQEGQLSIQMGPLSQRLALD 46260
46259 NISQVALGFDFGTLKHEKNAFHEHLIRIKKQIFHPFFLTFPFLDLLPIPSRKKAFKDVAS 46080
46079 FRELLVKRVQDELVNTYKFEQTTFAASDLIRAHNNEIIDYRQLTDNIVIILVAGHENPQL 45900
45899 LFSTSLYLLAKYSNVWQERLRQEVNGVTDPKILADLPLLNAFLLEAVRLYPPLSTIINRC 45720
45719 TTRTCKLGPEIVIPKGVYVGYNNFGTSHDPRTWGATADDFKPERWGSDIETIRKNWRMAK 45540
45539 NRCSVTGFHGGRRACLGEKLALTEMRITLAEMLKQFRWGLDPEWEEKLTPAGPLCPLNLK 45360
45359 LKFTENITE* 45330
CYP56A3 Saccharomyces bayanus MCYC 623
GenEMBL AACA01000139.1
83% to CYP56A1
23165 MSILQLIGFILLIIISYIAFVVVVPPLNFPRNIPTIPFYVVFLPVIFPIDQTELYDLYIR 22986
22985 EPMEKYGAVKIFFGSRWNILVSRSEYLAQIFKDEDTFAKSGNQKKIPYSALAAYTGDNVI 22806
22805 SAHGKVWRDYRNAVTNGLQHFDDAPISKNAKTFCNLIKKRAQNGESSIQMGPLSQRLALD 22626
22625 NISQVALGFDFATLTQDKNALHELLVHIKKQIFHPFFLAFPFLDLLPIPSRRKAFRDVAS 22446
22445 FRELLVKRVQDQLINNYKFEQTTFAASDLIRAHNNEVIDYKQLSDNIVIILVAGHENPQL 22266
22265 LFNTSLYLLAKYSTEWQNSLRQEVESVTNSKALADLPLLNAFLFEAVRLYPPLSTIINRC 22086
22085 TTKLCKLGADIVIPKDVYVGYNNFGTSHDPKNWGPTANDFRPERWGSDIETIRKNWRIAK 21906
21905 NRCTVTGFHGGRRACLGEKLALTEMRITLAEMLRQLEWTLDPEWEEKLTPAGPLCPFNLK 21726
21725 LNFKERLPS* 21696
CYP56A4 Saccharomyces castellii NRRL Y-12630
GenEMBL AACF01000075.1
63% to CYP56A1
43945 MPALRVILSLLIVLVGYVIFKVVWPPLNFPRNIPTIPCYVVFLPIIFDIDQVDIYNTYIK 43766
43765 VQMEKYGAVKIFFGSRWNILVSKPEYLAQIFKEEDVFAKSGNQKKIPYSAIAAYTGDNII 43586
43585 SAHGDVWRKYRSIMTNGLQHFKEEPFICNAKKFCGLLRKNRGPTG--NVLMGPLIQRLTL 43412
43411 DNISQVVLGFNFGTLSEETNELHQHLIKIKKQIFHPFFLTFPFFDMLPIPSRKKAFQDIS 43232
43231 KFREVLVSRVKNDLINNYKFEQTSYVSSDLIKAYNNNIIDYKQLTDNIVILLVAGHENPQ 43052
43051 LLLSNCLYLLAKYPS-WQKLIWKETQNISNYKDLNELPLFNSFLFEVVRLYPPLNIIINR 42875
42874 KTNKKCRMGQDIIVPKNTYVGYHNFGVTHNRNVWGNTAEEFDPRRWGTNIADIMIAWRSS 42695
42694 KNSCKLTSFHGGRRACLGEKLGFVEMRISIFEIIQQFELTLPKEWKEKMTPAGPLCPYNL 42515
42514 QLNIKSREKDVGVCE*42467
CYP56A5 Candida glabrata strain CBS138
GenEMBL CR380952.1, GenPept CAG59007.1
57% to CYP56A1
MLNILVFGFICLVLCWILTICFPPISFPNNIPTIPFYSVFIPQY
YNIDQVQFYNLYIREKLEKYGAVKFYFGSRWNILVSRPEFLNNIFKNEDTFAKSGNQQ
KIPYSVLAAYTGDNVISAHGVNWQKYRKPIKDGLQHFDIGILLKNAMKFCELIKEDMR
PFKYHCNFKIIPYIQRLTLDNICRVGLGFEFGAIDEDNNSLHRQLIQIKKQIFDPFYL
NFPMFDRLPIPSRLLAFQNVENFRSSLVDKVQKQLIKTYKFEQANTSGSALVRAYNNG
ELTYKQLTDNIVILLVAGHENPQLFISNLIYLLGKYHDTWQVDIRNEILNNEENNLSE
LPLLNSFLYECLRYYPPLSVIINRKTTKRCMLGPGIVVPKDTYVGYHNYSTCHDSNFW
GHTSDIFDPTRWGKDIETINKAWKTTKNNCILNTFHGGKRACLGEKLVFVSTRIIIAE
FLSSFEWKLSPLWVEQMTHAGPLCPKDLALDIRVRDTSMQIQKLNKYL
CYP56A6 Ashbya gossypii (= Eremothecium gossypii)
GenEMBL AE016819, NP_985947.1
54% to CYP56A1
MTANIVLVLLGGLVLNYIRSIVLPPWGFPRNIPTIPFYVTFLTT
LFDIDQKELFELYIRKPMEKYGAVKIYFGNRWNILVSKPEFLAQMFKDEDTFAKSGNH
IKIPYSILALYTGDNVISSHGLAWKKFRGALTQGLQFFDPSPLSANAEKFIGFIERDM
KKNNGEVLMPALIQRLALANIAQIALGFDIGTLDPERPSKLQQQLEEVKKHIFHPLYM
NFSFLDRLPIPSRIRARQQVERFRSDLLQEVRRNLIINYKYEQTSYAASDLIRVYEHG
EITEKQLTDNIVILMVAGHENPQLLLTTCLYMLAKYPEWQARLRQQAVTLQDDLLNDS
VEFNQFLFETVRVLPPLGQIINRKTSHKCKLGPEIVLPKDTYVGYQVYGTGTSTQVWG
PDAAEFKPERWGSTNATVHETWRRSKNTGAMGAFHGGRRACLGEKMGLMETRVALAHM
LRKLEWTLSPNWKDRVTPAGPLCPFMLKLQFTRIQEPLAAELTA
CYP56A7 Kluyveromyces lactis NRRL Y-1140
GenEMBL XM_452498, KLLA0C06743g
49% to CYP56A1, 53% to 56A6
MLSLVLGIISSGILLSFLCLVCFPIGLPWSLPTIPIYVSFLPIL
TDMDQLEIFERYIRHPMEKYGAVKIFFANRWNILTSKPEFLNIMFRDEDTFAKSGNQK
KIPYSLLAKYTGDNVISAHGKVWMKYRSCIQNQLNVFDSKPLIDNAQLFVKLLKKSIE
DNTEGTVLLPPLIQRLTLANIAKIALGFDIGTLKFDEHDNICRSRLHEKLNQVKQQIF
KPVFLSFPFLDLLPIKSRQRAKIDIIQFRDMLLDTVYKNLIHNYKFEQTNNAAAGLIR
EWKLQGITDEQLKDNLVIILVAGHENPQLLLSTLFYLLAKHQNWQYAIREELLSVDRN
EDILNSFKLTAFIYEALRMFPPLGQIINRRTTRKCQLGPGIIIDKDVYCGYNVYGTGT
ATSVWGETAKQFIPERWGENSNELANNWKKHKYDASMSAFHGGRRSCLGEKLALMEMK
YVLYYVLMNFHIELHPQWKEKMTPAGPICPKMLKVKLTILKDPQDQRSDSLYSSAGET
LSENI
CYP56A8 Saccharomyces mikatae
Smik_4197
90% to CYP56A2 Saccharomyces paradoxus partial seq
see Fungal pages for seq
CYP56A9 Saccharomyces kudriavzevii
AACI02001147.1, AACI02000561.1
85% to CYP56A3
see Fungal pages for seq
CYP56A10 Saccharomyces kluyveri
AACE03000001.1 Sklu_Contig1634.3
Cyan region is an insertion
60% to CYP56A3 Saccharomyces bayanus w/o the insert
see Fungal pages for seq
CYP56A11 Kluyveromyces waltii
kwal_162-g20.1
59% to CYP56A10 Saccharomyces kluyveri
similar insertion as in 56A10
see Fungal pages for seq
CYP56A12 Kluyveromyces polysporus
Kpol_364p9
62% to CYP56A3 Saccharomyces bayanus
see Fungal pages for seq
CYP56B1 Aspergillus nidulans
AN2706.1
43% to CYP56A1 547 clan
revised 7/18/07
MLVTLTVLFLGLVGILASFLTYLFTPPQFFPKGLPTIPFYYTLIPLLNQT
LKRAPTDQVTLYHRYLSTPLRTHGAVKLFFGGRWNILITKPSYIAEVLKN
EDLYAKSGNQKKIPHSVLAQYTGDNIISSHGENWKLYSSIFKPGLQRDYD
PSGIWRNASLLVQMISQDIKRKSPVDINPLMQRYALANLSEVLLGTTFDT
LQKPAASLHAFQLLIKPKIFDPIFLNFPVLDYLPLQTREEARKLVTRFTD
ELIETVRKGHTTCDHEKEHTRNLGCRLLYACESGLFTEMQLRHNMISAFL
AGHENPQLLLVSSLFLLAEHPEMQESLRAEISALNDLEPAYNALSALPLL
TSTIYEVLRLYPPISQLINRRTTAPTLLGGEIPIPAGTYVGYNAYATNRD
IGFWGPDANEFKPSRWGNTMEEINALFRRANAKGAFISFHGGRRTCLGQR
FALLEGRVTLAKLLMCVRWEIDPSWQRGMTPAGPLYARNLQLRFSNISGAGKAGAS
CYP56B2 Uncinocarpus reesii
UREG_00550.1
59% to CYP56B1 Aspergillus nidulans
see Fungal pages for seq
CYP56B3 Coccidioides immitis
CIMG_00523.2
80% to CYP56B2 Uncinocarpus reesii
see Fungal pages for seq
CYP56C1 Aspergillus oryzae
GenEMBL AP007164.1c
third P450 of six on this accession
CDS join(1160825..1161472,1161531..1162415,1162505..1162558)
47% to CYP56B1 Aspergillus nidulans
41% to CYP56A1 S. cerevisiae
MVMHGLCIIIGKALAVGILFLSICIFSRIVPPRYPRNIPAVPFW
VTLLSLVRDIDQEDIYRRHIQKPLQTHGAIKIFFAGQWNLLIQRSSYLNEIFRNEDVY
QKSGNQKKIPHSVLAEFL (1?)
GDNVISSRGTTWRLYRDIITPG
LQGHFDAGLIAANAEELCSSLLAFQNTVGNCGVPVQDLLQQFTIANVSQVLLQANHKP
TKGDESSLHQLQLAVKREIFKPIFMNFPVLDRLGKLIPCRVRARNVVEQFSAALQYGV
RHGQGTPNASNLGARLMAARDGGVLTGKQFRDNLNVLFVAGQENPQLLLISMLYLLAKHP (0)
DVQSRLRREIDACSTLDPSNVAFSELPYVTCVIYESLRLLP
PISQLINRRTSQDVILGNQIYIPKGTYVGYNCYSTNRDPAVWGPTADEFRPERWGQSN
TEISQCYRQRRARAEFVSFHGGSRACLGEKFALLEARVALFVLVSRLSWSLDPEWPDR
KTPAGPLYPRALRLIFTERK
CYP56C1 Aspergillus flavus
AFL2G_06061
98% to CYP56C1 Aspergillus oryzae
see Fungal pages for seq
CYP56C2 Uncinocarpus reesii
UREG_04911.1
60% to CYP56C1 Aspergillus oryzae
see Fungal pages for seq
CYP56C3 Aspergillus clavatus
ACLA_064250
53% to CYP56C2
see Fungal pages for seq
CYP56D1 Clavispora lusitaniae ATCC 42720
GenEMBL AAFT01000066.1, CLUG_02306.1
46% to CYP56A1
MLIDIIISNISVSFWCLCFFFLSWKIFRIIYPPFDFPKNIPTIPFYAAFVSSFLGWDQNK
VYAHYYRENLEKYGAAKIYFASRWNILVTKPEYLAQIFKQNEIFEKSGNQHKIPYSLLAE
YTGDNIISTGNKYWKLYRKAVTNSIQFPNLEPLQTNATVLIENLSAASDNGYFPIADILQ
AYTLNNVGDCVIGTNFHKSDNFDISTSLKKVKQEIFRPLFLNFPLLDLLPFPSRIRARKL
VRSFKRNYCNKILNELNEENKGRLGHNLATFWKQGDITEKQFQDNAMIAMIAGHENPQLL
LTSLIYVIAKYPEIQRQLRSEMNSSNYDVKEQIPLLKAVVYETIRLFPPLGLIVNRKTRK
NVILGNGIFIPKGTYVGYNNFGTQRDRNYWGDDADAFRPERWGNDGKKIEEKYAEAKSKC
TLPAFHGRSRACLGEKFALAEVRKAVIEILQNFEISLDPSWKEQLTPAGPICPLKLSVML
KKVCSEHEHNI*
CYP56E1 Candida tropicalis MYA-3404
GenEMBL AAFN01000070.1
45% to CYP56A1
MIMFDIVKYTLIGLFSYLLYVILDIVLPPFNFPKNIPTIPFYVSFLGAYTNLDQRDI
YNLYLREKLEKYGAVKIYFASRWNILITRPEYLLEMFRNEDVYSKRGNHLKIPGSVMATY
TGDNIISAHGELWKLYREVIAKSIQFPDFEPITKNTKSLLEIIDGMIDSDKNHAIIPITD
LFQKYSLANVTESILGVNFKVLEGDQSIMHQKIKYVKLQIFKPFFLNFPYFDSFPIPSRL
QARKEVINFRNWYGQSIIDKHDPQLPNSAATKLVDGLMQEKLTEKQFLDNAIIVMIAGHE
NPLLLMLSLMFVAAKYPKVQEAIRSEIDPTKPYLHSVIYETLRMYPPLGLIINRYTTRPT
KLGNIVIPKGVYCGYNNFGTGRDRNVWGPDSDEFKPERWGRDNIEEINRNYANAKRSAEL
PAFHGRKRACLGEKYALYEVKELLTSILGHYKVTLDASWKEKITPAGPISPFGLKVKFEK
LIVA*
CYP56E2 Candida albicans SC5314
GenEMBL AACQ01000054.1
45% to CYP56A1 missing N-term runs off the end of the contig
whole seq on orf19_554
151305 DFLLEMFKNEDVFAKSGNHVKIPNSVLATYTGDNIISAHGELWKLYRDVVAQSIQFPDLK 151126
151125 PISKNTQKLLRFLDNEMGSANQATISVTDILQKYSLANVCESVLGVNFNVLDDKQSLMHE 150946
150945 KIKYVKLQIFNPIFLNFPYFDNFPIPSRLKARREVIGFRKWYGQSLIEKYNLQLPN 150778
150777 SAATKLVDSLIKEKLTEKQFLDNAIILMIAGHENPLLLMLSLLYVVSKYPQVQELIRNE 150601
150600 TETTKPYLHSVIYETLRMYPPLGLIINRCTTRITKLGNIVIPKNVYCGYNN 150448
150447 FGTGRDRNVWGSDADIFKPERWGLEIDEINKKFTLAKRSAELPAFHGRKRACLGEKYALF 150268
150267 EVKQFLLAILGEYKVSLDPNWKEQLTPAGPISPLRLKLNFEKLTVS* 150127
CYP56E3 Candida dublinensis
cdub_14-g334.1
96% CYP56E2 Candida albicans (ortholog)
see Fungal pages for seq
CYP56E4 Candida parapsilosis
CPAG_05515
65% to CYP56E1 Candida tropicalis
see Fungal pages for seq
CYP56E5 Lodderomyces elongisporus
LELG_03266
runs of EE probably in an intron seq
59% to CYP56E2 Candida albicans
see Fungal pages for seq
CYP56E6 Pichia stipitis
JGI model e_gwh1.2.1.1913.1
57% to CYP56E4 Candida parapsilosis
see Fungal pages for seq
CYP56F1 Metarhizium anisopliae var. acridum Ma102
CYP56F1 Metarhizium anisopliae var. anisopliae Ma23
57A Subfamily
CYP57A1v1 Nectria haematococca MP VI (Fusarium solani group)
GenEMBL L20976 (3276bp) S70757 (1373bp) PIR S45583 (515 amino
acids)
Maloney,A.P. and VanEtten,H.D.
A gene from the fungal plant pathogen Nectria haematococca that
encodes the phytoalexin-detoxifying enzyme pisatin demethylase
defines a new cytochrome P450 family.
Mol. Gen. Genet. 243, 506-514 (1994)
PDAT9 pisatin demethylase
CYP57A1v2 Nectria haematococca (Fusarium solani group)
no accession number
Kevin McCkluskey and Hans Vanetten, Univ. Arizona
personal communication
pda4 pisatin demethylase
Note 98% identical to CYP57A1v1, probable allele
CYP57A2 Nectria haematococca (Fusarium solani group)
GenEMBL X73145 (2750)
Reimmann,C. and VanEtten,H.D.
Cloning and characterization of PDA6-1 a fungal gene encoding a
cytochrome P-450 which can detoxify the phytoalexin pisatin from
garden
pea.
Gene 146, 221-226 (1994)
high similarity to CYP57A1
CYP57A3 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_15000311
Necha1/scaffold_15:835216-837380
61% to CYP57A1
see Fungal pages for seq
CYP57A4 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_30000136
Necha1/scaffold_30:357529-359333
63% to fgenesh1_pg.scaffold_15000311, 57% to 57A1
This gene model seems correct DRN 2/5/06
see Fungal pages for seq
CYP57B1 Nectria haematococca (Fusarium solani group)
gw1.57.27.1
Necha1/scaffold_57:81298-82977
43% to CYP57A3
in CYP57 family, model short at N-TERM
see Fungal pages for seq
CYP57B2 Nectria haematococca (Fusarium solani group)
83% to CYP57B1
see Fungal pages for seq
CYP57B3 Aspergillus oryzae
GenEMBL BAE55311.1
56% to 57B2, 55% to 57B1
MIGTVLDTVLGNPQGAVGGLFVGSFVIFWVVPFLYNLFFSPLRNVPGPFWARFTILWEFSQLMKGRSHEE
YIKLHKKYGPVVRVSPKRYSVIDPQDVKKIYGFGADFPKSEFYDSLGDPKNIFTVRDNEDHKDRRRKVAS
LYTMSSMVAYEDAVDRMTTLCIKKMTDLAASRKLISIPKFMQFYAFDVIGEITFDQNFGMMENMGDTQGI
IKEIHAMNNTIGIMGLLPELQSTWRAAQKVLFSGTAMGKLTEYIWSQYWKHRNTNSGAKQKSQYDTFLRK
VLELEAAHKVGRMNVLDSCGSNIGAGSDTTGITLSAALWYIYRNPDKLAKLRHEIDTMTAEGRISDPVTY
KQAQEMPYLNAVIKETLRVHPGVGTILARVVPKGGITLTGGYYVPEGTHIGTNAWPLHYSETVYGPDADQ
YRPERWLEDKPQPDYRDSMMFAFGSGSRTCIGRNISLLEITKVLPQIVRKFDLKFEEKKDPWDAWCAWFV
YPKYKCWIEPRKPVENVA
CYP57B3 Aspergillus flavus
AFL2G_00227 revised
100% to CYP57B3 Aspergillus oryzae
see Fungal pages for seq
CYP57B4 Fusarium oxysporum
FOXG_01386
81% to CYP57B2
see Fungal pages for seq
CYP57C1 Mycosphaerella fijiensis
fgenesh1_pg.C_scaffold_2000556 revised N-term
51% to CYP57B3 Aspergillus oryzae
see Fungal pages for seq
58A Subfamily
CYP58A1 Fusarium sporotrichioides (filamentous fungus)
GeEMBL U22462 PIR S57337 (520 amino acids)
Hohn.T.M., Desjardins,A.E. and McCormick,S.P.
The Tri4 gene of Fusarium sporotrichioides encodes a cytochrome P450
monooxygenase involved in tricothecene biosynthesis.
Mol. Gen. Genet. 248, 95-102 (1995)
Note: also called TOX4
CYP58A2 Myrothecium roridum, complete cds.
GenEMBL AF009417 (4058bp)
Trapp,S.C., Hohn,T.M., McCormick,S. and Jarvis,B.B.
Characterization of the gene cluster for biosynthesis of
macrocyclic trichothecenes in Myrothecium roridum
Mol. Gen. Genet. 257 (4), 421-432 (1998)
(TRI4) gene
CYP58A3 Fusarium graminearum
CYP58B1 Aspergillus parasiticus
No accession number
Ken Ehrlich
Submitted to nomenclature committee 12/30/2003
40% to 58A1, 37% to 58A2 on the border of the CYP58 family
gene name CypA in aflatoxin biosynthesis
CYP58B1 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
join(3110..3314,3377..4218,4278..4388,4464..4630,4700..4871)
gene="aflU"
MASNTVYTSLIGLLVALTVRSIYRVYFHPLRKIPGPKIAAITHL
YQHYYDAVKGGKYIWKLDELHRKYGPIVRFNPNEVHIQDSHYYHHIYAGGAKKQDKDP
GFPAVPLFPGVTVTTIKHNHHRLRRGIIKSFFSKQYVTGLEHVIQSKVNLLASRFTEA
YRHGTVLDLKYVFAALTSDLTTHYVYGTNLNHLAEPDFKNDFLAGMDSVGPWIPVLLV
FGRLLKLARYLPACLVPAGEFLHLWTLSERRVGEILDSQDNGTMGDQKTLLQAMATAD
VSEEEKTATRLQMETLNIIAGGTETTARALAVGVFHLAHKPSLLLQLRDELRTVMPFP
DSSASWTQLEQLPYLAGVVNESLRLSFGFIIRSARVYPNDPLVYEDLVIPPGTPISQS
AYFVCMDPSIFPQPEDFNPDRWVQAAREGNNLHRYLIVFSKGSRHCLGINFALAEIYL
AIATIARRFDLVPYQTTVEQLQMKRDLGFAAPEKGPFTVRAKVTGLAD
CYP58B2P Aspergillus flavus NRRL3357 pseudogene
GenEMBL AAIH01000612.1, AFL2G_07229
missing first 29 aa, two frameshifts and one stop codon,
bad boundary at 1273
76 LRKIAGPKIAPITHLY*HYYDAVKGGKYIWKLDELHRKY (1) 192
255 GPIVRFNPNEVHIQDSHYYHHIYAGGAKKQDKDPEFPAVPLFPGVTVTTIKHNHHRLRRG 434
435 IIKSFFSKKYVTGLEYVIQSEVNLLASRFTEAYHHGTVLDLKYVFAALTSDLTTHYVYGTNLKX 623
626 LAEPDFKNDFLAGMDSVDPWIPVLLVFGRLLKLAGYLPACLVSAGEFLHLWT 781
783 LSERRVGEILDPQDNGTMGDQKTLLQAMATADVPEEEKTATRLQMETLNIIAGGTETTARALAV 974
975 GVFHLAHKPSLLLQLRDELRTVMPFPDSLASCTQLEQLPYSYL (0) 1103
1163 AGVVNESLRLAFGFIIRPARVYPNDPLVNEDLVIPFP (?) 1273
1362 TPISQSAYFVCMDPSIFSQPDDFNPDRWVQAARDGNKLHRYLIVLSKGSRHCLGIN (2) 1529
1599 FALAEIYLAIATVARRFDLVPYQTTVEQLQMKRDLGFTAPEKGPFTVRAKVTGLAD* 1769
CYP58B2P Aspergillus oryzae
Supercontig 10: 19609-20001 +
95% to CYP58B2P Aspergillus flavus
even pseudogenes are well conserved
see Fungal pages for seq
CYP58B3 Aspergillus nomius isolate AN13137
AY510454.1
8295-10054
92% to CYP58B1 Aspergillus parasiticus
gene CypA of aflatoxin biosynthesis
gene model revised
MVSKTVSTALIGLLVALILRSVYRVFFHPLRKIPGPKIAAITHL
YQHYYDAVQGGKYIWKLDELHRKYGPVIRFNPNEVHIQDSHYYHQIYAGGAKKQDKDP
GFPAVPLFPEVTVTTIKHHHHRLRRGIIKSFFSKQYVMGLEHVIQSKVNLLASRLTEA
YRHDTVLDLKYVFAALTSDLTTHYVYGTNLSHLTEPDFKNDFLAGMDSVGRWIPVLLV
FGRLLKLARYLPACLVPAGEFLHLWTLSERRVGEILGSKNNGTMGDRKTLLQAMATAD
VPEQEKTATRLQMETLNIIAGGTETTARALAVGVFHLANKPSLLLQLRDELRTVMPFP
DSTASWTQLEQLPFL (0)
AGVVNESLRLSFGFIIRSARVYPNDPLVYEDLVIPPG (0)
TPISQSAYFVCMDPSIFPHPEDFNPDRWVQA
ACEGHNLHRYMIVFSKGSRHCLGINFALAEIYLAIATVARRFDLVPYQTTVEQLQMKR
DLGFAAPEKGPFTVQAKVTGLAD*
CYP58C1 Aspergillus nidulans
see Fungal pages for seq
CYP58D1 Aspergillus nidulans
AACD01000172.1 Aspergillus nidulans FGSC A4 revised
see Fungal pages for seq
CYP58D2 Aspergillus oryzae RIB40
GenEMBL BAE58658.1
AP007157.1b (second P450 of 8 on this accession)
73% to CYP58D1
complement(join(191351..191525,191581..191747,
191803..191910,191973..192829,192878..193118))
MGVISVVTFLASAKEHFIISILLLFPIALILRTIYRLYIDPLHH
IPGPKLAAISHLYEFYHDVVRGGLFIWEIEKMHQEY
GPIVRINPREVHIKDPYFYDELYAPAHGWRDKDAKSVEIFSSPNA
LVSTVDHHTHRMRRKLLTSFFSRRSIERIEPVIHE
SLSKFLDSLITAYEEDSVVELIDRLQALTGHVITQYAYGEDYGLHEPQNIGKGIVKVV
QEGTEQIHLHRFFPLIQRFLRLIPSFFMTQLFPARAAMYDLLHGVRKKSIEVLQQKDV
CTPTERTTMFHALTAPEVPPEERTLQRLEDEGLVLFAAGTETTATTLGVAIFHILSDP
MVLTKLRKELEQVMPTPEGLATWRELEKLPYLNGVIHEALRFSGLAMRQQRVSPTEVI
KYKDYAIPPGTPVSMLQYFLHTDPALFSDPEKFYPERWMLAAERKESLSRFLVTFGKG
TRSCIGMNLAYAELHTALAAIVRRFDLELYETTAEDIRFVRDKLLPRAKNGPWRVRVK
VVGIRKD
CYP58D2 Aspergillus flavus
AFL2G_03972
99% to CYP58D2 Aspergillus oryzae
see Fungal pages for seq
CYP58D3 Aspergillus fumigatus Af293
GenEMBL XP_753152.1 also AAHF01000003.1
trichodiene oxygenase predicted
71% to 58D1
N-term part of broken gene
MRRKLLNNFFSRRSIENIEPVIHNSLSRFLDGLTTAYKEGSVVELIDRLQGLTGDVITEYAYGENYGLQD
PENYGKGIVKVVQEGTDQIHFFRFFPLVSQLLRIIPSWFMGQVFPARAAIYQLLDGVRKQSILALQQKNV
STAPQRMTIFQALTAPEVPPEERNLQRLQDEGLVLFAAGTETTATTLAVALFYN
CYP58D3 Aspergillus fumigatus Af293
GenEMBL XP_753171.1 also AAHF01000003.1
73% to 58D1
C-term part of broken gene
YILNDKRVLSKLRRELEQI
MPTPQHPTTWRELEKLPYLTAVIREALRFSGIVMRQQRISPTEALKYKDIVVPPGTPVSMIARFVHMDPT
IFPDPTRFHPERWMLAAGREEGLSKFLVTFSRGNRGCIGMNLAYAELYNTLAAVVRRFDLELNQTTPENI
RFVRDKLLPRSKDGSWTVRVKVVGIREQ
CYP58E1 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_14000019
Necha1/scaffold_14:58063-59829
48% to CYP58A3, 46% to CYP58A2
46% to 58A2 also 48% to 579A2, check 579A2 vs 58A2 = 65%
Note 58A2 and 579A2 are same family and same subfamily,
already revised names 579A2 = 58A3, not yet changed on blast server
This gene model seems correct DRN 2/5/06
Note this gene is near scaffold_14000017
see Fungal pages for seq
CYP58E2 Aspergillus oryzae
GenEMBL BAE59845.1
61% TO 58E1, 47% TO 58A2, 41% to 58C1, 46% TO 58A3
MLDTISESRPNGLATLGVVVATFATYLALKALYNLYLHPLRKFPGPKLAAIGPYYEFYYDVMKDGMFLWE
MERMHQVYGPIVRVNANEIHIRDPHYYSTVYAGNHRSTDKYHDAVAAFSVPQASLATIHHKVHRLRRSIL
NPYFSKAAVTRLESAINERIERMCSRLEETMHYGQVVDLDAGFAALTADIVTTYFYGQNFDYLGNEGFKF
QVRDAILGLIQFYHFTRFFPWIANTIKKLPIPIMRLIHPGAAYLVSSQEEIKDSIRASLDKGNKADAKSV
IVQALEDPTIPPQERTLDRLGDEGTTIIFAGTETTARALSVGMFHILNNKTILKKLREELDTLPGVSSGV
YSHVQLECLPYLTGAVQESLRLSHGPAIRLPRVANDKALKYGDYIIPPGTPVSLCTVLVHQDPCIFPDPH
RFDPERWVKASKEGVNLDKFIAAFTKGTRQCLGINLAYAEIYLTFAKLIRTFNMEIYDTTVDDLTVHHIR
LTGAPKQGTGEVKVKVTEKIL
CYP58E2 Aspergillus flavus
AFL2G_06877 revised
100% to CYP58E2 Aspergillus oryzae
see Fungal pages for seq
CYP58E3 Neosartorya fischeri
NFIA_042080
53% to CYP58E1
see Fungal pages for seq
CYP58E3 Aspergillus flavus NRRL3357
AAIH02002155.1
Identical to CYP58E3 Neosartorya fischeri
(partial seq, upstream part in a seq gap)
see Fungal pages for seq
CYP58E3 Aspergillus terreus NIH2624
AAJN01000124.1, ATEG_04417.1
93% to CYP58E3 = ortholog
see Fungal pages for seq
CYP58F1 Aspergillus oryzae
GenEMBL BAE64028.1
46% TO 58E2, 40% to 58C1, 45% to 58D1, 44% to 58B1
46% to 58A3
MALLVILGIGFVTYLVFLSIYRLYFHPLSHIPGPKLAAITHGYEFYHNIIRGGLFIWELERLHEVYGPII
RINPREVHIKDPDYYDDIYASSARKREKDPVLVAQFGLEGSGFSAIDQETHHQRRAPVAKFFSKRAIENQ
EHLIRDSLNKLVGHFQEACRAHTVVSLDAAFAALTSDVIHQYAYGFNPNNLDKEGFNAKVRDGINGLFQL
AHLLYFFPILQTLMNVMPLPLLQVLNPPAFALASQKKELYEQGAAALEKANSKAGSGTLIDTLAAPSMPE
HMRSAHRLMNEGFALVIGGTETTARSLALGAWHLFTREDIRNKLREELKQVMPTPDSQPTWNDLEKLPYM
SGVISESLRLSTGIANRSSRVAPTEALVYKDYTIPPGTPVSETNYFTLMDPEIFSDPHAFDPERWIRAAA
KGQRLDRYLVNFSKGSRMCVGLNLAYAELFLVIATIVRRFDIELYETPKSNIDFARDFGTPYPDKGNFSV
RALVTGVISE
CYP58F1 Aspergillus flavus
AFL2G_09007
99% to CYP58F1 Aspergillus oryzae
see Fungal pages for seq
CYP58F2 Aspergillus niger
fgenesh1_pm.C_scaffold_7000005|Aspni1
60% to CYP58F1
see Fungal pages for seq
CYP58F3 Aspergillus terreus
ATEG_04068.1
68% to CYP58F1
see Fungal pages for seq
CYP58G1 Aspergillus oryzae
GenEMBL BAE64022.1
40% to 58C1, 41% to 58D1, 39% to 58B1, 35% to 58A3
39% to 52E2, 41% to 58F1
revised 3/18/2009
MNLPLIWIGLFTAVSYLVIRSIYRLYFHPLSNFPGPKLAAVTHLYEFYYDVVKGGKFIWEMQRMHDQY
GPIVRINPREIHIKDPYYFDPIYTSKGQAKDPYIVRTFATPLSTAATVEHDRHRYRRDLVNPFFSKRSVMGVDYIV
QDKVDKVCKRLTQVHERGTVVSLDDLFAALTADVISHYAYGESLGFLDTENLKNEFRDAVASAGLLCHFA
RFFFVVSMVAETMPALVEWMQPSSKGLWEAKRMIEQMARSSLEKDHEKNANSRKTIFDALCAESVRPEER
TVARVRDEAMVVFGAGTETTARVLATGSYYLYRDKPRLEKLRAEIETVMPDSTDHVSLTQLESLPYLTAV
INESLRMAHSVTMRLPRISPTPLAYKDYIIPPG
TPVSQSVYFMHMDPTLFPNPDSFNPERWLEASSKGERL
TKFLVPFSKGSRICLGMNLAYSELYQMFATLVRCFDLEIQTPPESVRITRDFIIGLPDDADYLKVHSLVT
NAL
CYP58G1 Aspergillus flavus
AFL2G_09004
99% to CYP58G1 Aspergillus oryzae
see Fungal pages for seq
CYP58H1 Aspergillus oryzae
GenEMBL BAE56719.1
43% to 58B1, 44% to 58C1, 42% to 58D1, 38% to 58A3
42% to 58G1, 40% to 58E2, 42% to 58F1
MDEFTISAGSLCLLSLVVGFIIQSVYRLFFHPLRKFPGPKLGAISHLVQGLCFANNPKGPVVRINPRELH
INDPYYYEQIYAGSSRIREKDPRFIGVFTTPLPMVATVGHEHHRIRRGLLSSYFSRRALKKAELIIDQKV
DRLLVRFHSAFKCHAVLPLQRVFAALAADIVSEYCYGASQGYLEQKVFQNQMIDAVNYVMSMCHINKSIP
IIPKLLRCVPVGLMEKLGLQMADVIGVRNLIRRQAAKSLDKEWLSHDTNMLSKNVFDAIAAADVAPQEKT
LRRLEEEGAALFGAGIETTARALTVAMFHLISDETMIRKLRDELKQVMLSPASRPTWAELEQLPYLTGVV
NESLRLSFGLVARSPRVSPIESLAYGEYVIPPG (0)
TPVSQSAYFVHMNPQV
FPEPESFNPERWIKAAEKGQYLSRFLVAFSKGSRQCLGMNLAYAELYLTLARIVRLVDMKLVGTTIDNIR
VGRDLGHPAPKAGNFKVKVEVMGIASKS
CYP58H1 Aspergillus flavus
AFL2G_07403
98% to CYP58H1 Aspergillus oryzae
see Fungal pages for seq
CYP58J1 Aspergillus oryzae
GenEMBL BAE62179.1
41% to 58C1 46% to 58C1, 44% to 58D1, 41% to 58B1,
40% to 58A3, 43% to 58E2, 42% to 58F1, 41% to 58G1,
41% to 58H1
MDSPRLWTGLAGLITYLIVISVYRLFSHPLRNIPGPKLAAVTHLYEWYYDLFLGGKYLFEIERMHERYGP
IVRINPPEIHINDPKYYDEIYASGTHRRNKDAEFVSFTGLLLSSASTTDHDLHRYRRGLMNNFFSKKSVR
GISYFVEEKVHNLMQRFEAFYRCNKVVRLDDAFAAMTSDVITHYCYGKSWDYLDYANLRTDVRKAVRDLT
CSVHFNRIFPIFLAVLKKLPLRWLYAIHPGRSVVLDIQKTIYEQSAEAIHGDKYKIGHNDAVDKHKTIYD
QLTDPSIPAEERSLQRLQDEGLLLISVGTETTARALTTACFHIASDDQLRTRLREELRTVLPTPTSSVTW
SELEKLPYL (0)
TGTVNESLRLGGFLTTRSPRIAPDEPLTYKEYTIPPS (0)
TPVSSSSYFGHKNPNIFPEPEKFSPERWISAGRNNDHLFKYITSFSRGSRICAGMNLAF
LELYMTLAYFVRRFDVELVDTTVEDMKIVRDMRVGFTHRGEPTVYGRIVRVYED
CYP58J1 Aspergillus flavus
AFL2G_06095
98% to CYP58J1 Aspergillus oryzae
see Fungal pages for seq
CYP58K1 Aspergillus oryzae
GenEMBL BAE63021.1
41% to 58J1, 38% to 58A1, 40% to 58D2, 39% to 58C1,
38% to 58B1, 42% to 58J1, 37% to 58H1, 37% to 58G1,
39% to 58F1, 39% to 58E2
MVMDQAWTWMALVAIAGLFWITRIFYRLYFHPLAKIPGPKLAAASHLLEFYYDVILGGKFLFQVEKMHQK
YGPIVRINPKEVHIIDPTFYNEIYASGMRKRDKYEGFVRSLAADESTVSTVGSEKHRFRRSILQNFFSKR
SVMEFSSAIGERVEKLMRRLEVFEKTQTPVALDVVFSALTSDMITYICYGKDWKFLDHKDFNCDIHQAGV
DFANFFHFNRFFPWVFMTLRALSPRMLALLIPGRAATFKFQESLLKHAIEMAANEQSDAPSKETEKSRPN
VISNLINPSIPYMERSRRRLEDEVITILVAGTEAPVKVLSMAMYYLGSEPAIGEKLRAELKTILPARTST
ATYAELEKLPYLHGVVYESLRISDSVIARFPRIAPTETLRYKDHILPPGTPMSCSSYFISRNHDLFPNPE
KFDPERWIHAAEKGENLKQHLTAFTKGSRICLGINLTIAELFLTIAHMCRRYHILLHNTEPEDVCTTSDL
LAGYTRRGVLKVHAKLKAVRE
CYP58L1 Aspergillus niger
e_gw1.12.119.1|Aspni1
49% to CYP58D1, 49% to e_gw1.8.187.1
see Fungal pages for seq
CYP58M1 Aspergillus niger
e_gw1.8.187.1|Aspni1
51% to CYP58K1
see Fungal pages for seq
CYP58M2 Neosartorya fischeri
NFIA_057570
55% to CYP58M1
Note: this seq has no ortholog in A. fumigatus
see Fungal pages for seq
CYP58M3 Aspergillus terreus
ATEG_02828.1
55% to CYP58M1
see Fungal pages for seq
CYP58M4 Aspergillus terreus
ATEG_03531.1
57% to CYP58M1
see Fungal pages for seq
CYP58N1 Aspergillus niger
e_gw1.9.613.1|Aspni1
42% to CYP58C1, 39% to e_gw1.8.187.1
see Fungal pages for seq
CYP58P1 Aspergillus clavatus
ACLA_013370
49% to CYP58H1
see Fungal pages for seq
CYP58Q1 Aspergillus terreus
ATEG_02820.1
49% to CYP58M1, 48% to CYP58P1
see Fungal pages for seq
CYP58R1 Metarhizium anisopliae var. acridum Ma102
CYP58R1 Metarhizium anisopliae var. anisopliae Ma23
CYP58S1 Metarhizium anisopliae var. anisopliae Ma23
CYP58T1 Metarhizium anisopliae var. acridum Ma102
CYP58T1 Metarhizium anisopliae var. anisopliae Ma23
CYP58T2 Metarhizium anisopliae var. anisopliae Ma23
CYP58-un1 Aspergillus niger
gw1.19.191.1|Aspni1
43% to CYP58J1 pseudogene fragment C-term, 52% to CYP58M1
TPMGSSSDFIRRDPDNFPSLNNFTSTRWLMENGITIHSTRYLVSFSKGSRGRIEM ()
NLPYFELYLTVAYLVR
59A Subfamily
CYP59A1 Emericella nidulans
GenEMBL L27825 (4310bp)
Keller,N.P., Kantz,N.J. and Adams,T.H.
Aspergillus nidulans verA is reqired for production of the mycotoxin
sterigmatocystin
Appl. Environ. Microbiol. 60, 1444-1450 (1994)
gene stcS
note: C-terminal missing
Aspergillus nidulans (same as Emericella nidulans, Emericella is the
teleomorph sexual phase of the fungal life cycle.
GenEMBL U34740 (505 amino acids)
Brown, D.W., Keller, N.P. and Adams, T.H.
complete sequence of CYP59
Proc. Natl. Acad. Sci. USA 93, 1418-1422 (1996)
CYP59A1 Aspergillus nidulans
AACD01000132.1
stcS L27825 revised 7/20/07
MPSFSLLTGHFGALKQTIDGMPPNATLHSIMLKLSQKFRSGMFY
INMWPFSGTWLVVATPSGAAQIQSLNLSKPNILRRPLETITGGPSLMSMHGETWKRWR
ALFNPGFNPNYLIGLAPLIADEVVVFCEQLRQKARTGTVFQLEPLTLRLTVDTICSVT
LYVVTPVGRWPFLTPDLEIHSSTTKLRTTPLPQRCNGRSNGPRLELPSTPLRRYLTVR
PLVMWYNNRLMNRFIDQEVDRAYREQSGRQSKSVISLALRDYMKEKDGSLEDFKRRVA
PQLRVFLFAGRDTTSSTLLYAFYLLSRHPEALAKVRLEHDQVFGPYHQQVHEKIHQDA
KLLNQLPYTTAVLKETLRLFPPSASMREGGPGVEITDDNGQVYPTAGCNVWTLTVALH
HNSAHWAEAESFIPERWLVGSDHPLYPAKGAWRAFEFGPRSCIGQTLAMLELRVALAM
TLREFDIAPAYDKWDHIYPNDAVKEFNGHRAYQAEKGGGGAHPADGMPCLVTFRV
CYP59A3 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
join(43951..44429,44479..45478)
gene="aflN"
function="conversion of versicolorin A to
demethylsterigmatocystin
70% to CYP59A1
CYP59A4 Aspergillus oryzae
GenEMBL BAE59520.1 also BAE71324.1
72% to 59A1
MPEFQLLAGHFGTLKKTIQGMPSDATLHSIMLKISQQFPSGIFYINMWPFSGTWMIVSTPSAASQIQKLN
LSKPAILRRPLEMVTGGPSMMSMHGETWKKWRALFNPGFNPAYIIGLAPNISDEVAIFCAQLRKIAQQGE
VFPLESLTTRLTVDSICSVVLDTQLHHQIKDHPLATALQRQIDWTSFGTTFNPFKRYLTIRPLVLWYNNK
FMDRIIDGEVDRAYCTPPGHPSKSVISLALREYLQEQASNNSTRSLAEFKRLVAPQLRVFLFAGRNTTSS
TLIYTYYLLAQHPEALAKIRAEHGDVLGADPAEAQGRIKEDVQLLNKLPYTTAVIKETLRLFPPSASMRE
GRPDAEIIGEDGQRYPTVGCNVWTLTVALHHNSDYWDQVENFIPERWLVGPEDPLYPVKGAWRAFEFGPR
SCIGQTLAMLELRIALAMTIRQFDITPAYDEWDSIHPATTAREVNGHRAYQAERGAGGAHPADGFPCRVK
ERC
CYP59A5 Aspergillus oryzae
GenEMBL BAE48804.1
92% to 59A4, 71% to 59A1
MPEFKLLAGHFGTLKKTIQGMPSDATLHSIMLKISKQFQSGIFYINMWPFSGTWMIVSTPSAATQIQKLN
LTKPAILRQPPETVTGGPSMMTMHGETWKKWRALFNPGFNPAYIIGLAPNITDEVATFCAQLRKKAQQGE
VFPLESLTTRLTVNSICSVVLDTQLHHQIKDYPLATALQRQINWTSFGTTFNPLKRYFTIRPLVLWYNNK
VMDRIIGGEVDRAYRTPPDHPSKSVISLALREYLQEQASSNSTRSLAEFKRLVAPQLRVFLFAGRNTTSS
TLIYTYYLLAQHPDILAKIRAEHEDVLGVNPEEVQGRIKEDAQLLNKLPYTTAVIKETLRLFPPSASMRE
GRPDAEIIGENGQRYPTVGCNVWTLTVALHHNSDHWNQVESFTPERWLVGPEDPLYPVKGAWRAFEFGPR
SCIGQTLAMLELRIALAMTIRQFDITPAYDEWDSIHPATTSKEVNGHRAYQAERGAGGAHPADGFPCRVK
ERF
CYP59A5 Aspergillus flavus
AFL2G_07219
96% to CYP59A5 Aspergillus oryzae
see Fungal pages for seq
CYP59A6 Aspergillus nomius isolate AN13137
AY510454.1
join(49221..49702,49768..50767)
94% to CYP59A5 Aspergillus flavus
gene VerA of aflatoxin biosynthesis
MPEFKLLAGHFGTLKKTIQGMPSDATLHSIMLKISQQFPSGIFY
INMWPFSGTWMIVSAPSAASQIQKLNLTKPAILRRPLETVTGGPSMMSMHGETWKKWR
ALFNPGFNPAYIIGLAPNIADEVATFCTQLRKKAQQAEVFPLESLTTRLTVDTICSVV
LDTQLHHQIKDHPLATALQRQIDWTSFGTTFNPVKRYLTIRPLVLWYNNKVMDRIIDS
EVDRAYRTPPDRPSKSVISLALREYLKEQSSSSSTRSLAEFKRLVAPQLRVFLFAGRN
TTSSTLIYTYYLLAQHPEVLARIRAEHEDVLGGDPADAQGRIKEDVQLLNKLTYTTAV
IKETLRLFPPSASMREGRPDAEIIGEDGQRYPTVGCNVWTLTVALHHNSDHWQQVESF
IPERWLVGPEDPLYPVKGAWRAFEFGPRSCIGQTLAMLELRIALAMTIRQFDITPAYD
EWDSIHPATTAREVNGHRAYQAERGAGGAHPADGFPCRVKERC*
CYP59A7 Aspergillus ochraceoroseus strain SRRC 1432
AY092402.3
join(9134..9615,9669..10671)
gene StcS/AflN in aflatoxin/sterigmatocystin biosynthesis
76% to CYP59A5 Aspergillus flavus
MPEFKLLAGHFAALKQTIQGMPPNATLHSIMLKLSQQFPSGIFY
INLWPFSGTWMIVATMTAASQIQSLNLTKPAILRRPLETITGGPSLISMHGETWKRWR
ALFNPGFNPAYLIGLAPNIADEVAVFRNQLRKKAQQGDIFSLEPLTLRLTVDTICSVA
LDARLFHQQKDHPLAVALQRQIEWASFGTTFNPVKRYLTIRPLVLWYNSRLMNRLIGK
EVDRVHNARPGYSSKSVISLALKQYLKEQSNGDTRQSLEAFKRQVAPQLRVFLFAGRD
TTSSTLLYTFYLLAKHPEILERVRREHDEVFGTDIKKAQSCIAEDPQLLNKLPYTLAV
IKETLRLFPPSASMREGRPDVEIVGDDGRRYPTAGCNVWTLTVALHHNSNHWPEVESF
IPERWLVGHEDPLYPAKGAWRAFEFGPHSCIGQTLALLELRIALAMTLREFNITPAYD
EWDRLHPRDTIKEVNGHRAYQMEKGGGGAHPADGLPCRVTLRTT*
CYP59B1X Fusarium graminearum (Gibberella zeae PH-1)
GenEMBL AACM01000117.1
52362-54017 (+) strand, one intron
renamed CYP5071A1
CYP59C1 Aspergillus nidulans
AN5766.2
44% to 59A1 586clan?
Revised 7/18/07
MAVTNLVLTLSIPLLTVIGYGLYCGFQHRRKINELRKRGIPMPKDWSWLT
GHLLSLKKYTDRLPADAHVLLPTHELAVEFADTEMFLMDTWPVFPALVMV
YDPDAALQISTKYNLPKSAIFPSLMHPITGGPSMISMNDAEWKKWRSIFN
PGFSAGNMVDQVSTVVDSVQVFCDILREKAGTGLVHLDDLTTRLTMEVIL
KVTLDMDSNYQRSDNEMVHALNTITKWHSFWDPRVRANPLRPLVQKYYGR
VMDRCIRKELDKRFAEMQQGQRSASTSKRVKSVIALALEAYLADYHQKDG
KASKLDDNFAQYATHQIRLFLFAGNDTTSSSIVYVYHMLSKHPKALARVR
QEHDRIFGTLPSAAPQLLKSNPALLNQCPYTLAVIKETLRLFPPASTTRE
GRDGVTLTDRLGNSYPLGHTIGAEIIHPTIHKNPRLWPQAEEFIPERWLV
DPGHELYPSPAAWRPFEHGPRNCIGQTLVYNEMRIVIVMTARTFNIRPAY
DEWDAMHAAKEGLL (0)
TVHGERAYQTEKAGTHPADGYPCHVALCSGSPIS*
CYP59C2 Aspergillus niger
e_gw1.2.1390.1|Aspni1
63% to CYP59C1
see Fungal pages for seq
CYP59D1 Aspergillus oryzae
GenEMBL BAE66084.1
AP007175.1
55% TO 59D2, 41% to 59A1, 41% to 59C1
470087 MVIAVSDLVGSYGARVALVLALVIVLRFLQEMLKVRLLFYRLRKQ
GLPMPKWNFAAGNLQMLPDLMKRHP
KGSQQSEAFTLLSYEFASSDNCFYIDVWPFTKPLLVVNSPDLAVQACQTYALPKPPVLAKFFNPFAGGPS
IFTTNGPEWKRNRGLFNPAFSTSNILQHTPHI 470671
VEEAEEYVEILREHARKGDTFTLDKMTCDYVLDIIGRVAM (2)
KARLHSQRGRNPVAAALRSQVEWHCQDEQMNPFIRWNPMRPIMQWCNGRTM
NQYIGAELDKRYEAWTQNKPSTRANSIIDIVLAEYMSTRPVRAALDPEFKSWAT
IQLRTFLFAGHDSTAATIVYSIYLLSKHPEILSKVRTEHDEVFGSDISAAAGILKQHPEL
INRLPYTLAVIKETLRLFPAASALREGQPGVYLQDKNGTKYPTEGLCIWIIHGGIQRNPN
YWPDPHAFKPERWLVGPDHPLYPPKGAWRPFEQGLRDCIGQALALLDVKITLVLTLREFD
FQDQYAHWDRLHPRSGPKTVFGERAYQIPQGGSHPVDGLPCRVSLRNQITK*
CYP59D1 Aspergillus flavus
AFL2G_11439
99% to CYP59D1 Aspergillus oryzae
see Fungal pages for seq
CYP59D2 Aspergillus oryzae
GenEMBL BAE58153.1, AP007155.1
37% to 59A1, 37% to 59C1
2825205 MGANTLGWDGLTSRIAVAVATVCLTSFVYKLIKMRLMFYRLRKKGL (0) 2825068
2825008 PTPPWNPILGNLAVMAQLQKKWPSDSREAESFALLSTEAPGCEAGFYVDVWPFSIP
MLVVTSPALAVQACQTYDLPKPDVLQPFINPMAGGSDNLFVSNGAHWKQARELFNHGFSMAAAMSHMTYI
LEEAQVFVQMLKDHARKGDTFSLDALTCRYVMDIIGNVA LNTRFRFQEQHNPIAAAMRDTIELECGIETS
NFLSRWNPRRLYRQWQNGRTMDYLIGVELDKRYKEWRETAKSSSHPRTQSIMDMVIAEYMKTRPQAQQQQ
ELDPEFKRWATIQIRLFLFVGHDSEATTIIYSLYLLSKNPGVLIKVRAEHDRVFGAGVSSAYDVLTDHPE
KINQLSYTHAVIKETLRLFPPANGLRGGLPGVSLRDEQGRIFPTEGCAIWIVHTAVHRNPSSWPQPHAFI
PDRWLVEPGHPLYPPAGGWRPFEQGPRNCIGQNISLLGIKASLAMLVRQFDFHDAYAEYDRLHPSTGLKT
MFGERAYMIQKGAGHPAQGFPCKVTLR
CYP59D2 Aspergillus flavus
99% to CYP59D2 Aspergillus oryzae
see Fungal pages for seq
CYP59D3 Aspergillus niger
e_gw1.12.714.1|Aspni1
63% to CYP59D2
see Fungal pages for seq
CYP59E1 Mycosphaerella graminicola
Mgr034
39% to 59C1, 9/10 top hits are CYP59, but only 34% to 59D3
N-term is short
see Fungal pages for seq
CYP59E2 Mycosphaerella fijiensis
e_gw1.7.674.1
61% to CYP59E1 Mycosphaerella graminicola
see Fungal pages for seq
60A Subfamily
CYP60A1 Aspergillus parasiticus
GenEMBL L40839 (1266bp) L41149 (1284bp)
Yu,J., Chang,P.-k., Cary,J.W., Wright,M., Bhatnagar,D.,
Cleveland,T.E.,
Payne,G.A. and Linz,J.E.
Comparative mapping of aflatoxin pathway gene clusters in
Aspergillus
parasiticus and aspergillus flavus.
Applied Environ. Microbiol. 61, 2365-2371 (1995)
gene ord1
missing N-terminal (approximately 93 amino acids missing)
CYP60A2 Aspergillus nidulans
GenEMBL U34740 (507 amino acids)
Brown, D.W., Keller, N.P. and Adam, T.H.
Proc. Natl. Acad. Sci. USA 93, 1418-1422 (1996)
gene stcF
CYP60A2 Aspergillus nidulans
U34740 AN7818.1
53 clan, note the CYP60 family falls inside the
much larger CYP65 family that has grown
stcF revised 7/19/07
MILPLILVLYLLSTAAYRLWLHPVRNYPGPCWWAVWRVPYLKGT
IRGTIVRDIQRLHNQYGPVVRIAPDELSYITPEAAKPIYTSSPEFPKDPMLLPPFHNG
APGILAADYAHHRRYRRLLASAFSEKGLRAQQGMIQSHIDRLMTRLQGNCSSGSLDMT
VWFNWATFDIIGDLAFGEPFGCLERMETNPWIASIQGNVKSIPILNALRRYRLDRLIE
FLAPPRLLEMRRRNAQFTAEKVDRRLKHATTTRGDLWDSVLADPPDGEPPMSRAEMVS
NASAIVLAGSETSATTLSGCLWLLLTNPEYLQQLTERIRARFSTATVIDAQTVTQIQG
LQAVLDESLRLYPAVPMQSNRIVPPPGARLAGSWVPGGTSVAVQQFAACRSPTNFHRP
DEFIPERWEKEGEFINDRREASQPFSIGPRNCIGRQLALAEMRLILVHLLWHFDIELD
RRRMENMDWMAVQGI
WILWDKKPLWVVLKNRST*
CYP60A3 Aspergillus parasiticus
GenEMBL U62774
Yu,J., Chang,P.K., Cary,J.W., Bhatnagar,D. and Cleveland,T.E.
avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved
in the conversion of averantin to averufin in aflatoxin
biosynthesis in Aspergillus parasiticus.
Appl. Environ. Microbiol. 63, 1349-1356 (1997)
CYP60A3 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
complement(join(46528..46863,46931..48025,48072..48128))
gene="aflG"
function="conversion of averantin to 5'-hydroxyaverantin
70% to CYP60A2
note CYP60A1 and CYP60A3 are essentially the same sequence
the CYP60A1 sequence is incomplete and has 4 amino acid differences.
CYP60A4v1X Aspergillus flavus strain SRRC 141
GenEMBL AF106960
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene 85% identical to 60B2
note: error in name assignment, this gene is CYP60B4v1
MYFLSLPALAIVIPVGYVLFQLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VANTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIKKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPYKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFMKTRGTSSSSPQ
CYP60A4v2X Aspergillus flavus strain SRRC 1007
GenEMBL AF106959
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene
99% identical to 60A4v1
note: error in name assignment, this gene is CYP60B4v2
CYP60A4v3X Aspergillus parasiticus strain RH1
GenEMBL AF106958
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene
97% identical to 60A4v1
note: error in name assignment, this gene is CYP60B4v3
CYP60A4v3X Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
complement(join(48496..48846,48901..50052))
gene="aflL"
function="conversion of versicolorin B to versicolorin A"
note: error in name assignment, this gene is CYP60B4v3
CYP60A5 Aspergillus oryzae
GenEMBL BAE71325.1, BAC45242.1, BAE59521.1
95% to CYP60A3
MGGDGWPSDGHILLLIVLTVLTPPSLALYRLWIHPLRSYPGPRWWAIWRGPYILSNIRGNLVRDLQRLHQ
QFGHVVRIAPNELSFIVPEAASPIYTSNPEFPKDPMHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSDK
GLRQQRSLIERSVNLLITRLHENCGQGPLDLTLWFNWATFDIIGDLAFGNSFGCLDNVQTHPWISSIQGN
VKLIPILNAFRRYRLDGLLQLLGSRKLLEQRRRNAQFTTDQVDRRLKNSSTPRGDIWDAVLAQKPDGEPP
MSREEMISNTSAIVLAGSETSATLLSGCTWLLLKNPGHLHQLTSRIRSQFTHASEIDSQSVSRVEGLQAI
LEESLRLYPPVPMQSNRIVPQSGAYIAGGWVPGGTSVGLQQFVACRSSSNFHRPEEFLPERWQGQGEFAH
DRREVSQPFSIGPRNCIGRQLAYVETRLILVKLLWHFDLRLDTTRMKDTDWLAEQGIWILWDKNPLWVNL
EPRNE
CYP60A5 Aspergillus flavus
AFL2G_07217 revised
98% to CYP60A5 Aspergillus oryzae
Bottom HALF (two adjacent P450s in this gene model CYP60B3 and CYP60A5)
see Fungal pages for seq
CYP60A6 Aspergillus nomius isolate AN13137
AY510454.1
complement(join(51845..52180,52258..53352,53400..53456))
92% to CYP60A3
gene AvnA of aflatoxin biosynthesis
MGVDGWLSDGHFRLLILLIVLTPPSLAVYRLWIHPLRSYPGPRW
WAIWRGPYILSNTRGSLVRDLQRLHQQFGPVVRIAPNELSFIAPEAAAPIYTSNPEFS
KDPMHLPPFHNGTPGILAADHAHHRRYRRLLAFSFSDKGLRQQRGLIERSVNLLITQF
HENCGQGPLDLTLWFNWATFDIIGDLAFGDSFGCLDNVQTHPWIASIQGNVKLIPILN
GLRRYRLDGLLRLLGSRKLLEQRRRNAQFTTDQVDRRLQNSSTPRGDIWDAVLAQKLD
GEPPMSRAEMISNASAIVLAGSETSATLLSGCTWLLLKNPEHLHQLTSRIRSEFSHAS
EIDSQSVSRVEGLQAVLEESLRLYPPVPMQSNRIVPSTGAHIAGGWVPGGTSVGLQQF
VACRSPSNFHRPDEFLPERWQGQGEFAHDRREVSQPFSIGPRNCIGRQLAYVEMRLIL
VKLLWHFDLRLDTTRMKGTDWLAEQGIWILWDKKPLWVTLEPRDK
CYP60A7 Aspergillus ochraceoroseus strain SRRC 1432
AY092402.3
complement(join(29656..30030,30172..31266,31338..31385))
gene AflG in aflatoxin/sterigmatocystin biosynthesis
79% to CYP60A3 Aspergillus parasiticus avnA
gene model revised at one intron boundary
MDVLRSFPLQLLGLRDFLILGSLGAYRLWLHPLRSYPGPRWWAL
WRVPYLQSTIRGTIVRDLQRLHEQYGPVVRIAPDELSFINPEAAKPIYTSNPEFSKDP
MHLPPFHNGVPGILAADHAHHRRYRRLLAFSFSDKGLKAQQGMIQQYIDQLIVRLHEN
CSTGPVDMTLWYNWATFDIIGDLAFGESFGCLEKVETHPWIASIQGNVKAIPILNALR
RYRLSGVLGLLAPRNLLEMRRRNAQFTADKVDRRLQHPGTARGDLWDSVLADNPNGES
PMSRDEMVSNASAIVLAGSETSATLLSGCTWLLLKNPEYLNTLTERVRSQFARAADID
AQTVTQVEGLQAVLEESLRLYPPVPMQSNRIVPPQGAQIAGMWVPGG (0)
TSVAVQQFVACRSADNFHRPNEFLPQRWQGQGEFANDRREASQPFSIGPRNCIGRQLAYAEMRL
ILVHVLWHFNLRLDQGRMKDADWLAEQGIWILWDKNHCGLCWNRGREKVEEDDAT*
60B Subfamily
CYP60B1 Aspergillus nidulans
GenEMBL U34740 (501 amino acids) AN7813.2, revised 7/18/07
Brown, D.W., Keller, N.P. and Adam, T.H.
Proc. Natl. Acad. Sci. USA 93, 1418-1422 (1996)
gene stcL
MAFLSLPILTALGA
VVYVLFQLVYNLYFHPLRDYPGPLLW
RASSLPWKLTLLRGTMHHDLMRHHQTYGDTVRIKPDEISYANGQAWRDIHAHVPGRPE
FLKDPVRLPLAPNGVMSILVSDTRNHARFRSLFGHAFSDKGLRAQEPTIARYADLLVE
VLREVADTGKSVEMVRYFNMAIFDSIGALSFGESFDSLRNRELHPWVDTIHKNLKSVA
ISHVLRSMGVEFLAPYLMPAELRGKRQENYTYAIEKLKKRMQKTGDQGDFWDRVIVKS
ADGNQSGDGMSYGEMINNAAVMVVAGSETTSSALCGCTYLLCKFDKMDKAVAEVRGAF
AAADQIDLVSVSRLPYLTAVIDETLRMYPSVPGQPPRVVPEGGAIVCGRFVPAETRVG
VSHLGAYYAPYNFSHADKFIPERHLAGAKLEEPFRHDNYAAYQPWSVGVRNCIGRNLA
YAEVRLTLAKLLWHFDISLDEERTGNFLDQKIWSIWAKRELYLEIRTREF
CYP60B2 Aspergillus ochraceoroseus strain SRRC 1432
GenEMBL AY092402.3
complement(join(46781..47113,47181..48332))
Cary,J.W., Beltz,S.B., Bennett,C.A. and Klich,M.A.
Molecular Characterization of the Aflatoxin Biosynthetic Cluster
from Aspergillus ochraceoroseus.
Unpublished
function="desaturation of aflatoxin precursor VER B to VER A
84% to CYP60B1 Aspergillus nidulans StcL
probable ortholog of CYP60B1
gene AflL/StcL
MALPTLPVLAVLIGASYILVQLVYNLYFHPLRDYPGPLLWRASS
LPWKFTLLRGTMHHDLMRFHQKYGDTVRIKPDEISFANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPIGVMSILVSVTRFLARFRSVFGLAFSVKGLRAQEPTIVQYADLLVEVLRE
VADTGKSVEMVHYFNMAIFDSIGALSFGESFDSLKNRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYTYAIEKLKRRMQMTGDQGDFWDRVIVKSADGN
QSGDGMSPGEMLNNAAVMVVAGSETTSSALCGTTYLLCQSGKMEKAVAEIRNAFPTPD
KIDLVTVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGKFLPAETRVGVSHL
GAYYADYNFTRPEKFIPERHLQKMEEPFKHDNYGAYQPWSVGVRNCIGRNLAYAEVRL
TLAKLLWHFDITLDEAKTGNFLDQKIWSIWANGELYMSFKARKV
CYP60B3 Aspergillus oryzae
GenEMBL BAE71326.1, BAC45243.1, BAE59522.1
81% TO 60B1
probable ortholog of CYP60B1
MYFLSLPALAIIVPVGYVLLHLGYNLFFHPLRGYPGPLLWRASSLPWKIALLRGTMHHDLMRFHQKYGDT
VRVKPDEISYANAQAWRDIHAHVPGRPEFLKDPVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGL
RTQESTIVQYADLLVEVLREMANTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNL
KSVAISHVLRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDLGDFWDKVLVKSADDNQRGD
GMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKATAEIRKSFASPEDIDLISVSHLPYLAAV
IDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHLGAYFADYNFTHADKFIPERHLQKTEEPY
KYDNYGAYQPWSVGLRNCIGRNLAYAEVRLTLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFIK
TRGTSSSSPQ
CYP60B3v1 Aspergillus flavus
AFL2G_07217 revised
97% to CYP60B3 Aspergillus oryzae
TOP HALF (two P450s in this gene model CYP60B3 and CYP60A5
see Fungal pages for seq
CYP60B3v2 Aspergillus flavus strain SRRC 141
GenEMBL AF106960
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene 85% identical to 60B2
97% to 60B3v1 ortholog
99% to CYP60B3v3 Aspergillus flavus strain SRRC 1007
formerly CYP60B4v1
MYFLSLPALAIVIPVGYVLFQLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VANTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIKKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPYKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFMKTRGTSSSSPQ
CYP60B3v3 Aspergillus flavus strain SRRC 1007
GenEMBL AF106959
formerly CYP60B4v2
MYFLSLPALAIVIPVGYVLFQLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VANTGCSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKVEKATGEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPYKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSSPQ
CYP60B3 Aspergillus parasiticus strain RH1
GenEMBL AF106958
formerly CYP60B4v3
MYFLSLPSLVIVIPVGYLLFHLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRFHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPASGATVCGRFVPEETRVGVSHL
ATYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSSPQ
CYP60B3 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
formerly CYP60B4v3
MYFLSLPSLVIVIPVGYLLFHLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRFHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIEKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPASGATVCGRFVPEETRVGVSHL
ATYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMFIKTRGTSSSSPQ
CYP60B3 Aspergillus nomius
AY510454
complement(join(53898..54266,54322..55473))
gene VerB of aflatoxin biosynthesis
94% to CYP60B3 Aspergillus flavus
MYFLSLSVLALVTLVSYVLFHLGYNLFLHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAEAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTRNHARFRSLFGHAFSDKGLRTQESTILQYADLLVEVLRE
VADTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMRMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGSMYLLCLSGKIEKATAEIRKSFASPE
EIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGKFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPFKYDNYGAYQPWSVGIRNCIGRNLAYAEVRL
TLAKILWHFDFTLDVDKTGNFLDQKIWSIWAKRELYMTLKSRDTSCSWPSTSSSPQ*
CYP60B4v1X Aspergillus flavus strain SRRC 141
GenEMBL AF106960
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene 85% identical to 60B2
note: error in name assignment, this gene was erroneously called
CYP60A4v1
probable ortholog of CYP60B1
note: Asp. oryzae and Asp. flavus are very closely related species
This seq is 97% identical to CYP60B3
Their P450 genes are nearly identical
So this is the ortholog/ same gene as 60B3v2
MYFLSLPALAIVIPVGYVLFQLGYNLFFHPLRGYPGPLLWRASS
LPWKIALLRGTMHHDLMRYHQKYGDTVRIKPDEISYANAQAWRDIHAHVPGRPEFLKD
PVRLPLAPNGVMSILVSDTKNHARFRSLFGHAFSDKGLRTQESTIVQYADLLVEVLRE
VANTGRSAEMVYYFNMAIFDSIGALSFGESFDSLKSRQLHPWVDAIHKNLKSVAISHV
LRSMGIEFLTPYVLPKELRGKRQENYSYAVEKLNKRMKMEGDQGDFWDKVLVKSADDN
QRGDGMSAGEMLNNAAVMVVAGSETTASALSGAMYLLCLSGKIKKATAEIRKSFASPE
DIDLISVSHLPYLTAVIDETLRMYPAVPGQPPRVVPAGGATVCGRFVPEETRVGVSHL
GAYFADYNFTHADKFIPERHLQKTEEPYKYDNYGAYQPWSVGLRNCIGRNLAYAEVRL
TLAKLLWHFDFTLDVGKTGNFLDQKIWSIWAKRELYMFMKTRGTSSSSPQ
CYP60B4v2X Aspergillus flavus strain SRRC 1007
GenEMBL AF106959
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene
99% identical to 60B4v1
note: error in name assignment, this gene was erroneously called
CYP60A4v2
probable ortholog of CYP60B1
renamed CYP60B3v3
CYP60B4v3X Aspergillus parasiticus strain RH1
GenEMBL AF106958
Bhatnagar,D., Cary,J.W., Ehrlich,K.C., Cleveland,T.E. and
Payne,G.A.
Molecular characterization of an aflatoxin B2 producing mutant
strain of Aspergillus flavus
Unpublished
verB gene
97% identical to 60B4v1
note: error in name assignment, this gene was erroneously called
CYP60A4v3
probable ortholog of CYP60B1
renamed CYP60B3
CYP60B4v3X Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
complement(join(48496..48846,48901..50052))
gene="aflL"
function="conversion of versicolorin B to versicolorin A"
note: error in name assignment, this gene was erroneously called
CYP60A4v4
probable ortholog of CYP60B1
renamed CYP60B3
61A Subfamily
Note: all fungi have CYP61 a C-22 sterol desaturase in the ergosterol
biosynthesis pathway. These will just be called CYP61 without subfamilies
assigned. A few older names were 61A1-61A5. The sequential numbers may not
be needed, except in rare cases where there are more than one CYP61 in a single
species.
CYP61A1 Saccharomyces cerevisiae (yeast)
GenEMBL Z49211 (30,011bp) PIR S54015
Lye,G. and Churcher,C.M.
Unpublished 1995
Barrell,B., Rajandream,M.A. and Walsh,S.V.
S.cerevisiae chromosome XIII cosmid 9711 complement of 3155-4771.
CYP61A1 Saccharomyces paradoxus
98% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Saccharomyces mikatae
97% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Saccharomyces castellii
83% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Saccharomyces bayanus
93% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Saccharomyces kluyveri
79% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Kluyveromyces waltii
82% to CYP61A1 S. cerevisiae C-term part only
See the fungal pages for seq
CYP61A1 Yarrowia lipolytica
GenPept CAG84120.1
64% to CYP61A1 Saccharomyces paradoxus
See the fungal pages for seq
CYP61A1 Ashbya gossypii ATCC 10895
NP_982999.1
75% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Pichia stipitis
JGI model estExt_genewise1_human.C_chr_6.10410
82% to CYP61A1 Debaryomyces hansenii
See the fungal pages for seq
CYP61A1 Debaryomyces hansenii
CAG86871.1
80% to CYP61A1 Candida lusitaniae
See the fungal pages for seq
CYP61A1 Lodderomyces elongisporus
84% to CYP61A2 C.albicans
CYP61A2/61A1 C.albicans
GenEMBL AL033396 comp(39932..41485)
gene="Ca35A5.10c" 68.9% identical to 61A1
note: most fungi have onlt one CYP61 gene
so this is probably the ortholog of CYP61A1
but for historical reasons it was named CYP61A2
CYP61A1 Candida guilliermondii
79% to CYP61A1 Candida dublinensis
See the fungal pages for seq
CYP61A1 Candida parapsilosis
79% to CYP61A2 C.albicans
See the fungal pages for seq
CYP61A1 Candida lusitaniae
78% to CYP61A2 C.albicans
See the fungal pages for seq
CYP61A1 Candida dublinensis
96% to CYP61A2 C.albicans
See the fungal pages for seq
CYP61A1 Candida glabrata CBS138
GenPept CAG62657.1
81% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Candida bombicola, alternative name Starmerella bombicola
No accession number
Inge Van Bogaert
Submitted to nomenclature committee Jan. 17, 2012
63% to CYP61A1 Saccharomyces kluyveri
CYP61A1 Kluyveromyces polysporus
86% to CYP61A1 S. cerevisiae
See the fungal pages for seq
CYP61A1 Kluyveromyces lactis
80% to CYP61A1 Saccharomyces kluyveri
See the fungal pages for seq
CYP61A1 Uncinocarpus reesii
75% to CYP61A1 Aspergillus fumigatus
See the fungal pages for seq
CYP61A1 Histoplasma capsulatum G217B
77% to CYP61A1 Uncinocarpus reesii
ABBT01000205.1 Ajellomyces capsulatus G217B 1837477-1839379 (+)
ABBT01000210.1 Ajellomyces capsulatus G217B 225529- 227431 (+)
Two identical sequences. Note 51F2 also has two identical sequences
One of them is also on ABBT01000205.1 and
the other is on ABBT01000207.1
See the fungal pages for seq
CYP61A1 Coccidioides immitis
90% to CYP61A1 Uncinocarpus reesii
See the fungal pages for seq
CYP61A1 Fusarium graminearum
FG01959.1 AACM01000104 FGcontig1.104_scaffold1
See the fungal pages for seq
CYP61A1 Nectria haematococca (Fusarium solani group)
88% to CYP61A1 Fusarium graminearum
See the fungal pages for seq
CYP61A1 Magnaporthe grisea
See the fungal pages for seq
CYP61A1 Ustilago maydis
GenEMBL XM_397965.1
in the 61 clan 49% to CYP61 N.crassa
See the fungal pages for seq
CYP61A1 Sporobolomyces roseus
JGI gene model estExt_fgenesh1_pm.C_40050
57% to CYP61A1 Ustilago maydis,
See the fungal pages for seq
CYP61A1 Malassezia globosa
74% to CYP61A1 Ustilago maydis
See the fungal pages for seq
CYP61A1 Aspergillus nidulans
AN4042.1
66% to 61A1 51 clan revised 7/19/07
MAEINGSFVSPAADATVFPQVFQPAGLIADFLNGLTLWKTLATLFALAVV
YDQFRYIYLKGAIVGPAWKLPFMGPFLQSVNPKFHEYKAKWDSGELSCVS
VFHKFVVIASTRDMSRKIFNSPTYVKPCVVDAAHKLLGKTNWVFLDGKEH
VDFRKGLNNLFTRQALSCYLPRMEEVYNDYYARFLKKSKNNNYKPTPWMP
EFRDLMCAVSCRTFVGHYISDEAIDKISVDYYNITAALELVNFPIILPFT
KTWYGKKAADMVLDEFAKCAAKSRARMAAGGEISCIMDAWIKAQLDSAKY
REKIAKGIEVDSSEKPPQVLRDFTDYEVSQTIFTFLFASQDATSSACTWL
FQLMADRPEILDKVREENLRLRNGDVNAPLTMDLLDSMTYTRAVVKETLR
YRPPVIMVPYIAKKDFPITDKITVAKGSMIIPSVYPATRDEEAYPNADSF
DPDRWITGTAEQHPKNFLIFGTGPHYCLGQTYAVLNLMAMIGKASMEMDW
VHTPTPQSEEIKVFATIFP (0)
DDCLLTFRPRA
CYP61A1 Aspergillus oryzae
GenEMBL AP007155.1, BAE58068.1
MANVTGSFVSPSADATVVPQLFQPSGLLGSLLGDFNVWKGLLTLFIAAVIYDQ (0?)
FRYFYQKGSIVGPRWKLPFMGPFLQSVNPKFHEYKAKWDSGELSCVSVFHK (2?)
FVVIASTRDMSRKIFNSPAYVKPCVVDSAHKLLGEDNWVFLDGKDHVEFRKGLNGL
FTRSALSCYLPRQEETFNQYFKHFLEKSKANGYKPTPWMPEFRELMTAISCRTFVGHY
MTDEVIQKINDDYYLITAALELVNFPIILPFTKTWYGKKAADMVMEEFAKCAAKSKAR
MAAGGEVSCIMDAWVKAQQVSAKYREDVAKGIPAEKPPQLLRDFTDEEIAKTVFTFLF
ASQDATSAASTWLFQLMADRPEVLEKVREENVRLRNGDINAPITMELLDQMEYTRAVV
KETLRYRPPVIMVPYLVKKDFPITEKITVLKGSMIIPSVWPATHDEEAYPNPDTFDPD
RWITGTAEQNPKNWLVFGTGPHYCLGQTYAQLNLMAMIGKASMEMTWEHTTTPKSEDI
KVFATIFPQ (0?)
DDCLLTFRPRA
CYP61A1 Aspergillus flavus
100% to CYP61A1 Aspergillus oryzae
CYP61A1 Aspergillus fumigatus Af293
GenEMBL XP_750145.1
cytochrome P450 sterol C-22 desaturase
81% to 61A1 Aspergillus oryzae
MANVNGSFVSPSADATISPQLFYNVDSLSAVLNGFTFWKALATLFFAAVIYDQLRYFYLKGSLVGPTFKL
PFMGPFLQSVNPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPAYVKPCVVDIAHKLLGPD
NWVFLDGKEHVEFRKGLNGLFTRSALSSYLPVMEECYNKYYKYFLEKSKANDYKPEPWMPEFRELMCAVS
CRTFVGHYMTDAAIKKIADDYYMITAALELVNFPFILPFTKAWYGKKASDMVLEEFSNCAAKSKAHMAAG
GEITCIMDAWVKAQQDSAKYNEKIAKGLPVEDSEKPSHLLREFTDYEIAQTVFTLLFASQDATSAACTWL
FQLVADRPDVLEKIREENLRVRNGNINAPLTMDLLDEMKYTRAVVRETLRYRPPVIMVPYLVKKDFPITD
SITVSKGSMIIPSVWPATHDPEAYPNPDSFDPDRWITGDAEKQAKNFLVFGTGPHYCLGQTYAQLNLIAM
IGKASLEMDWEHAPTPKSEDIKVFATIFPEV
CYP61A1 Neosartorya fischeri
99% to CYP61A1 Aspergillus fumigatus = ortholog
See the fungal pages for seq
CYP61A1 Gibberella moniliformis 7600
AAIM02000091.1
95% TO FUSARIUM GRAMINEARUM 61A1
99% to 61A1 F. oxysporum
also called Fusarium verticillioides FVEG_07284
MEAVNATSSGFSSVLAGTKYVNVALPPQVEYVIEAVSNAGVWTWVFTFIALCVAYDQ (1)
350695 IAYIIRKGPIEGPAMKLPFIGPFLDSMDPRFDGYHAKWSSGPLSCVSIFHK (2) 350847
350776 FVVIASTRDMARKVFNSPAYVKPTVVDVAPKLLGHDNWVFLDGKAHVDF 351054
351055 RKGLNGLFTRKALESYLPGQEEAYNTYFKHFLKMTKDAGGKPVPFMHEFREVMCAVSCRT 351234
351235 FVGHYISDEAVTKIAEDYYLITAALELVNLPVILPYTKSWYGKKAADMVLAEFSKCAA 351408
351409 KSKVRMAAGGEVTCIMDAWVLSMIQSERWREAEEKGEGHTVEKPAPLLRMFNDYEISQTI 351588
351589 FTFLFASQDATSSAATWLFQVTAQRPDVLDRVREENIKVRNGDPNAPITMDQLESLTYTR 351768
351769 AVVRELLRWRPPVIMVPYVTKKAFPLTENYTVPK (1)
GSMLI 351948
351949 PTTFMALHDPEVYDNPSHFDPERYYSGDAEEKGSKNYLVFGTGPHYCLGQVYAQLNLALM 352128
352129 IGKASVMLDWKHHATPKSEEIKVFATIFPM 352218
DDCPLTFEERKW*
CYP61A1 Fusarium oxysporum
99% to 61A1 Gibberella moniliformis
See the fungal pages for seq
CYP61A1 Aspergillus clavatus NRRL
NZ_AAKD03000006.1
87% TO ASPERGILLUS FUMIGATUS CYP61A1, 52% TO CYP61A6 A. clavatus
468671 MANINGSFVSPSADATLSPQFFQSAEFLPAILNGFTIWKALVTLFIAAVIYDQ (1) 468513
LRYFYLKGSLVGPTFKLPFMGPFLQSVNPK 468315
468314 FHEYKAKWDSGELSCVSVFHK (2)
FVVIASTR 468135
468134 DMSRKIFNSPAYVKPCVVDVAHKLLGADNWVFLDGKDHVEFRKGLNGLFTRSALSCYLPE 467955
467954 MEECYNQYYKRFLKKSKANQYKPEPWMPEFRELMCAVSCRTFVGHYITDEAVQKIADDYY 467775
467774 MITAALELVNFPFILPFTKAWYGKKASDMVLQEFSNCAAKSKARMAAGGEISCIMDAWVK 467595
467594 SQLDSAKYREKIANGVPPEEAGKPSHLLRDFTDYEIAQTIFTFLFASQDATSAACTWLFQ 467415
467414 LMADRPEILDKVREENVRVRNGDITAPLSMDLLDQMTYTRAVVKETLRYRPPVIMVPYLV 467235
467234 KKDFPITDSVTVAKGSMIIPSVWPATHDPEAYPNPDSFDPDRWITGDADKHPKNWLVFGT 467055
467054 GPHYCLGQTYAQLNLMAMIGKASMEMDWVHTPTPESEDIKVFATIFPQ 466911
DDCHLTFRPRA*
CYP61A1 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_12230|Aspni1
84% to CYP61A1
See the fungal pages for seq
CYP61A1 Aspergillus terreus
87% TO CYP61A1 Aspergillus niger
70% to CYP61A1 Aspergillus terreus
55% to CYP61A6 Aspergillus terreus
ATEG_03815.1
MATVNGSFVSPSADATIVPQLFAPSGLIGSVLEGFTVWKALLTLFLAAVIYDQLRYFWLKGSIVGPAMKLPFMGPFLQSV
NPKFHEYKAKWDSGELSCVSVFHKFVVIASTRDMSRKIFNSPAYVKPCVVDAAHKLLGADNWVFLDGRDHVDFRKGLNGL
FTRQALSCYLPRMEEVYNDYYARFLKKSKDVNYKPVPWMPEFRELMCAVSCRTFVGHYITDEAVQKIADDYYLITAALEL
VNFPIILPYTKTWYGKKAADMVLEEFSKCAAKSKARMAAGGDISCIMDAWVKQQLDSARYRENVAKGVPVDENEKPAQVL
RDFTDYEIAQTIFTFLFASQDATSAACTWLFQLMADRPEVLDKVREENLRVRNGDVNAPLTMDVLESLTYTRAVVKETLR
YRPPVIMVPYLVKKDFPVTDKITVSKGSMIIPSVWPATHDEEAYPNADSFDPDRWITGTAEQQSKNWLVFGTGPHYCLGQ
NYATLNLMAMIGKASMEMNWEHTPTPQSEDIKVFATIFPQDDCLLTFRPRA
CYP61A1 Metarhizium anisopliae var. acridum Ma102
CYP61A1 Metarhizium anisopliae var. anisopliae Ma23
CYP61A1 Mycosphaerella graminicola
67% to CYP61A1 A. oryzae
See the fungal pages for seq
CYP61A1 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_20563
80% to CYP61A1 Mycosphaerella graminicola
See the fungal pages for seq
CYP61A1 Chaetomium globosum CBS 148.51
NZ_AAFU01000895.1 AAFU01000895.1
84% TO N. CRASSA 61A1
MAANATTSPLATIKYGAASVAPQLEYVIDYVSNASTLSILATILATLVVYDQ (1)
6856 FRYILNKGSIAGPAWKMPFIGPFLQSMNPKFEEYYAKWLSGPLSCVSVFHK (2) 7008
7135 FVVIASTRDMARKVFNSPAFVKPCVVDVAHKLLGADNWVFLDGKAHVEF 7215
7216 RKGLNGLFTRRALEIYLPGQEEVYNRYFKEFVATTKQAGGEPVPFMTHFREVITAVSCRT 7395
7396 FVGHYITDEAVKKIADDYYLITAALELVNFPIILPYTKTWYGKKAADMVLAEFAKCAA 7569
7570 KSKARMAAGGEPNCIMDAWIIQMIQSQRWRDAQAKGDTEGVEKPTHILRDFTDYEISQTV 7749
7750 FTFLFASQDATSSAATWLFQIMAQRPDVLDRVREENLNVRNGDINAAVNMDQLESMTYTR 7929
7930 AVVRELLRYRPPVLMVPYVVKKPFPITETYTAPK (1)
GSMVIPT 8109
8110 TYMALRDPEVYDRPDEFDPERYYTGDAEVKGMKNYLVFGTGPHYCLGQQYAQLNLALMVG 8289
8290 KASLLLDWKHHATPKSEEIKVFATIFPM 8373
DDCPLTFEDRKW*
CYP61A1 Phanerochaete chrysosporium (white rot fungus)
Scaffold_75 JGI gene model ug.78.18.1
62% to CYP61A1 Usilago maydis
the sequence GYVLQYCLVLYAMLTHRR seems to be an
insertion and it may need to be removed
MASSQAAFPSTLSDSSRHSTDSPAFIGLLPTGSWF
YTTAAILLSLLVIEQSVYRYKKRHLPGDKWTIPLIGKF
ADSMKPTMEGYMKQWNSGALSAISVFNV
RFIVMASTTEYARKILNSPTYAEPCLVHSAKQIILPDNW
VFLTGKEHVEYRRGLNLLFTRKAL GYVLQYCLVLYAMLTHRR SLYLGIQDVITRKHFAKW
LADAAKDPSAKPIMMTARELNMETSLRVFCGNHIPEHGAKEISDKYWMITVALELVNFPL
AIPGTKVYNAIQARKAAMKWLELAARKSKESVAAGNPPECMLEEWVTILNDPAYKGR
REFSDHEMAMVVFSFLFASQDAMSSGLIYGFQHLADHPEVLAKVREEQER
VRGGDYEKPLTLEMMDEMPYLRAMVKETLRVKPPVTMVPYKTTKAFPISQDYTVPSGSMV
IPSFYNSLHDPAVFPDPDRFMPERWLDPNGSANTNPRNYLVFGSGPHKCIGLEYAMMNIA
LVLANAAVLMNWEHELTPQSDKVQIIATLFPQDGCKLKFSPRQHA*
CYP61A1v1 Postia placenta (brown rot basidiomycete fungi)
CYP61A1v2 Postia placenta (brown rot basidiomycete fungi)
CYP61A1 confidential basidiomycete
CYP61A1 Cryptococcus neoformans var. neoformans B-3501A chromosome 6
AAEY01000030
CNBF1100
ESTs gb|CF191501.1|CF191501,gb|CF188802.1|
CF188802, gb|CF194425.1|CF194425
EAL20298.1
61% to CYP61A1 Ustilago maydis
See the fungal pages for seq
CYP61A1 Cryptococcus gattii
CNBG_1921 Transcript 1. Broad Institute
98% to CYP61A1_Cryptococcus_neoformans var. neoformans B-3501A
MESHTILRPTAIPDLAAIKTWGLEGLTKAKFSFDSKTTTATILTLILSLLVLEQLVYRAK
KAHLPGAKWTIPVIGKFADSLNPTLANYKAQWNSGPLSAVSVFNIFIVIGSSNEMARKIL
NSPNHAEPCLVASAKKVLLPENWVFLHGKVHADYRKALNVLFTKQALSIYLPIQEKIYRS
YFNKWTSDPAPAQQYMMKMRDLNMETSLSVFIGPYLTEAQKQEINEKYWLITISLELVNF
PLAIPGTKVYNAIQARKIVMKYLSAASAASKIRMEDDDAEPECLLDHWVRAMILARRAQD
DGEETKLLSREYSDHEIAMVLLSFLFASQDAMSSALVYTFQLTADHPEVLAKVREEQYRV
RGNDLERPLTLDLLDDMVYTRATIKEVLRFRPPVIMVPYMTTKPFPVSPEYTAPKNSMII
PAFWNSLHDETCYPEPDRFLPERWLPQADGSAPIADSKPQNYLVWGSGPHKCIGGQYASM
HLAATLGTASVLMDWKHERTELSDEVQVIAAIFPKDHCLLKFTPRAPPS*
CYP61A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
65% to P450-8 = CYP61 C-22 sterol desaturase
53% to CYP61A3 S. pombe
P450-10_var1
See the fungal pages for seq
CYP61A1 Grosmannia clavigera
CYP61A3/61A1 S. pombe
GenEMBL Z98974 join(10345..10419,10514..12001)
gene="SPAC19A8.04" 51% identical to CYP61A1
note: most fungi have onlt one CYP61 gene
so this is probably the ortholog of CYP61A1
but for historical reasons it was named CYP61A3
CYP61A1 Schizosaccharomyces japonicus
80% to S. pombe CYP61A3 (misnamed, should be CYP61A1)
See the fungal pages for seq
CYP61A1 Schizosachharomyces octosporus
See the fungal pages for seq
CYP61A4/61A1 Botrytis cinerea (a plant-pathogenic fungus infecting over 200
plant species)
GenEMBL AL111744 AL111746
Bitton,F., Levis,C., Fortini,D., Pradier,J.M. and Brygoo,Y.
58% to S. pombe 61A3
note: most fungi have onlt one CYP61 gene
so this is probably the ortholog of CYP61A1
but for historical reasons it was named CYP61A4
CYP61A5/61A1 Neurospora crassa
No accession number
Neurospora crassa sequence contig 1.384 (supercontig 48)
note: most fungi have onlt one CYP61 gene
so this is probably the ortholog of CYP61A1
but for historical reasons it was named CYP61A5
4488 MASNATSFTSPLASAKLGTVAVPPQLEY
4404 VIDTISQASGWTIVFTLLAVLVAWDQ (0)
VKYVLNKGTIA 4225
4224 GPSWKIPFIGPFLESLDPKFEEYYAKWLSGPLSCVSVFH (2) 4108
4037 KFVVIASTRDMARKVFNSPSYVKPCVVDVAHKLLGADNWVFLDGPAHVEFRKGLNGLFTR 3858
3857 RALEIYLPGQEEVYNRYFKSFLEITKNAGGKPVPWMPHFREVITAVSCRSFVGHYISDEA 3678
3677 VKKIADDYYLITAALELVNFPIIIPYTKTWYGKKAADMVLAEFAKCAAKSKVRMAAGGEA 3498
3497 TCIMDAWIKQMIDSKKWREAVASGNTEGLEKPTHLLRDFTDYEISQTIFTFLFASQDATS 3318
3317 SAATWLFQIMAQRPDVLDRVREENLKVRNGDIHAPINMEQLESMTYTRAVVRELLRYRPP 3138
3137 VLMVPYLVKKAFPITEDYTIPKGSMVVPTTYMALRDPEVYPNPDYFDPERYYSGDAEAKG 2958
2957 AKNYLVFGVGPHYCLGQHYAQLNLALFVGKASLLLDWKHHPTPLSEEIKVFATIFPKVSL 2778
DRSCCSACRDFFLLTLYRMTVPSLSRSASGKQRGFWVWTSI*
CYP61A1 Neurospora discreta
JGI gene model estExt_fgenesh3_kg.C_120065
98% to CYP61A5 N. crassa ortholog of CYP61A1
See the fungal pages for seq
CYP61A6 Fusarium graminearum
A second CYP61 gene in Fusarium graminearum
CYP61A6 Nectria haematococca (Fusarium solani group)
79% to CYP61A6 Fusarium graminearum (ortholog)
only 56% to 61A1 F. graminearum
55% to CYP61A1 Nectria
See the fungal pages for seq
CYP61A6 Aspergillus oryzae
GenEMBL AP007155.1, BAE57461.1
73% to CYP61A6 Nectria haematococca
MDAKMATEIFNTTSAQPESPQSWAYKTSQLQGALPDFLAEWSAWQYVVTFLVGLVLYDQ (1?)
VLYLKRKGALPGPTFKIPLMGPFIQAIHPTFDGYLRQWASGPLSCVSIFHK (2?)
672882 FVVLASDRDLAHKVFKSPAYAEPCLVPVARDIIGHKAWVFLQGRDHAEYRRGLV 673043
673044 PLFTSRAIATYLPVQERVLDDYYNQFVAATKANQGKPMAFMTLFREINCALSCRTFFGDY 673223
673224 ISDDQVKKIADDFYLATDALDLVNIPLAMYVPFTKTWLGKRTADAVHRVFAECAARCKAN 673403
673404 MAKGATPTCIVDHWVLHMMESNRYRERVAAGETNLEKPKNMIREFTNEEISDTLFTFLFA 673583
673584 SQDASSSATTWLFQILAQRPDVLDKLREENLAARGGDRNKPFDLPMLESLTYTNAVIKEL 673763
673764 LRYKPPVILVPYLATKDFPVTPDYTVPKGSMIIPSCYPALHDPEAYPNPDVFDPERWISG 673943
673944 DAESKTKNWLVFGAGPHDCLARKYVPLSLAGMIGKASLELDWEHHPTPRSEEIRVFATLFPM (0) 674129
DGCNLVFKRRP*
CYP61A6 Aspergillus flavus NRRL3357
AAIH01000781.1
Only 1 aa diff to 61A6 of Asp. Oryzae,
73% to CYP61A6 Nectria haematococca
MDAKMATEIFNTTSAQPESPQSWAYKTSQLQGALPDFLAEWSAWQYVVTFLVGLVLYDQ
VLYLKRKGALPGPTFKIPLMGPFIQAIHPTFDGYLRQWASGPLSCVSIFHR (2)
6085 FVVLASDRDLAHKVFKSPAYAEPCLVPVARDIIGHKAWVFLQGRDHAEYRRGLV 5924
5923 PLFTSRAIATYLPVQERVLDDYYNQFVAATKANQGKPMAFMTLFREINCALSCRTFFGDY 5744
5743 ISDDQVKKIADDFYLATDALDLVNIPLAMYVPFTKTWLGKRTADAVHRVFAECAARCKAN 5564
5563 MAKGATPTCIVDHWVLHMMESNRYRERVAAGETNLEKPKNMIREFTNEEISDTLFTFLFA 5384
5383 SQDASSSATTWLFQILAQRPDVLDKLREENLAARGGDRNKPFDLPMLESLTYTNAVIKEL 5204
5203 LRYKPPVILVPYLATKDFPVTPDYTVPKGSMIIPSCYPALHDPEAYPNPDVFDPERWISG 5024
5023 DAESKTKNWLVFGAGPHDCLARKYVPLSLAGMIGKASLELDWEHHPTPRSEEIRVFATLF 4844
4843 PM (0) 4838
DGCNLVFKRRP*
CYP61A6 Gibberella moniliformis
GenEMBL AAIM01002518.1
81% to CYP61A6 Nectria haematococca
also called Fusarium verticillioides FVEG_08786
29769 MTSIVSPRHEAAISNASSTLKEDISNG
29688 NGLLSSYLNGYSNAQILLAILVVLIAYDQCMYLWRKGPIAGPAFKIPFMGPFIRALYPKF 29509
29508 DHYLAQWASGPLSCVSVFHK (2) 29456
29396 FVVLASDRDIAHKVFKSPTYAKPCIVPMAETLLRPNAWVFLQGKAHTEYRKGLNGLFVN 29220
29219 KALSTYLPVQEKVYDDYFGRFVAASEANKGKPMAFMRLFREINCALSCRTFFGDYISQDA 29040
29039 VEKIADDFYEVTAALELVNVPLSVYVPFTKCWKGKRTADAVLAEFAKCAAACKANMTSGA 28860
28859 EPRCIVDQWVLHMMESKKYNDRIAAGEEGVEKPRNLIREFTDDEIGQTMFTFLFASQDAS 28680
28679 SSATTWLFQVLAQRPDVLDRLREENLAVRNGNRHQPFELSMLESLPYTNAVIKELLRYRP 28500
28499 PVIFVPYEATKSFPVTPKYTVSKGTLIVPTCYPALHDPQAYPNPETFDPDRWITGDAESK 28320
28319 TKNWLVFGAGPHDCLARKYVPLTMAAMIGKASLELDWVHHATSRSEEIRVFATLFPE (0) 28149
28084 DECQLVFTKRE* 28049
CYP61A6 Trichoderma reesei
GenEMBL AAIL01000244.1
75% to CYP61A6 Nectria haematococca
MATIIEGSMPISFESTINATQHGTSGLVESLWSSCSAASNWQIAITALLVLVAYDQ (1)
10081 YLYISRKGSIAGPTFKIPLIGPFLQAIYPKFDAYLAQWASGPLSCVSVFHK (2) 9929
9869 FVVLASDRDLAHKVFKSPTFVRPCLVPMAINIMRPTAWVFLNGKAHAEFRRGLTGLFTN 9693
9692 KALSTYLPVQEKVYADYFNRFVEHSKANGGKPTKFMGWFREINCALSCRTFFGDYISQEA 9513
9512 VKRIADDFYLITDALELVNIPLSIHVPFTKCWRGKRTADAVLEEFTKCAAACKVNMASGA 9333
9332 QPTCIVDQWVQHMFESKRYNEAVAAGVEGLEKPTNLIREFSDEEIAQTLFTFLFASQDAS 9153
9152 SSATTWLFQILAQRPDVLDRLRAENLAARGGDKNRPFELEMLESLTYTNAVVKELLRYRP 8973
8972 PVIFVPYLALKPFPVTPDYTVPKNAMIIPSCYPALHDPAAYPNPDVFDPERWITGDAETK 8793
8792 TKNWLVFGAGAHDCLARRYVPLTMAAMIGKASLELDWVHHATERSEEIRVFATLFPM (0)8625
DECPLVFTRRE* 8517
CYP61A6 Aspergillus terreus NIH2624
GenEMBL AAJN01000026.1
76% to CYP61A6 Nectria haematococca
MNVKMQADMANSTQPDRQIWHVTTHWQGKVSDSFSGWSACQYIVTILLGVIFYDQ (1)
44968 VMYIKRKGSIAGPTFKMPLMGPFLQAINPKFEEYLAQWASGPLSCVSVFHK (2)45120
45171 FVVLASDRDLAHKVFKSPSYAEPCLVPIAKDILGPKAWVFLQGKAHAEYRRGLTPLFT 45344
45345 NNALATYLPVQDKVFATYFDKFVAASAANNGRPMEFMTMFREINCALSCRTFFGDYISQD 45524
45525 AVKKIADDFYLVTAALELVNIPLSMYVPYTKPWLGKRTADAVHAEFARCAAACKANMASG 45704
45705 AAPTCIVDHWVLHMMESNRYRERVAAGEANVEKPTNLIREFTNEEIGETLFTFLFASQDA 45884
45885 SSSATTWLFQVLAQRPDVLDRVRDENLAARGGDKSKPFDLPMLEGLTYTNAVVKELLRHR 46064
46065 PPVIFVPYLATKNFPVTPSYTVPKGSMIIPSCYPALHDPAVYPDPDVFEPERWISGDAES 46244
46245 KGKNWLVFGAGAHECLAKRYVPLSMAAMIGKAALELDWTHHATERSEEIRVFATLFPM (0) 46418
DGCQLVFRKRS* 46499
CYP61A6 Chaetomium globosum CBS
GenEMBL AAFU01000675.1 148.51
74% to CYP61A6 Nectria haematococca
796 MAADHVNASSSTPELLMSSSGLASGSSSWQFRDGVVGITAEWSAWQYVITLLLGLVVYDQ (1) 975
1031 VMYLYRKGSITGPRFKVPLTGPFIQALHPKFESYLAQWASGPLSCVSVFHK (2) 1183
1242 FVVLASDRELAHKVFKSPTYTEPCIVPLAKDILGHKAWVFLQGKAHAEYRRGLTPLFT 1415
1416 NKAMATYLPAQEKVFADYFDKFVAASQANVNQPLPFMTLFREINCALSCRTFFGDYISPA 1595
1596 AVKKIADDYYQATAALELVNVPFSIYIPFTKPWRGKRTADAVHAEFAKCAAACKRNMATG 1775
1776 AAPTCIVDHWVRHMFESNRYRERVAAGETDVEKPSNLIREFTDVEISETLFTFLFASQDA 1955
1956 SSSATTWLFQILAQRPDVLDRLREENLAARGGDRNKPFDLAMLESLTYTAAVVKELLRYR 2135
2136 PPVIFVPYLATKAFPITPDYTVPKGAMVIPSCYPALHDPKVYPNPDTFDPDRWITGDAES 2315
2316 KTKNWLVFGAGAHDCLARRYVPLTMAAMIGKAALELNWKHVATEKSEEIRVFATLFPM (0) 2489
DGAQLVFEKRP* 2579
CYP61A6 Aspergillus clavatus NRRL
GenEMBL AAKD02000011.1
77% to CYP61A6 Nectria haematococca
MDTEIANVSRAAAQSGSPQAWT
669433 PQPSSGQNTLLDCLAGWSTWQYLVTFLLGIVVYDQ (1)
669274 VMYLKRKGSIAGPAFKIPLMGPFLQAIHPKFDAYLAQWASGPLSCVSVFHK (2) 669122
669053 FVVLASDRDLAHKVFKSPSYAEPCIVPIAKDIIGHKSWVFLQGKAHAEYR 668904
668903 RGLTPLFTNKAMATYLPVQEKVFTDYFDRFVTASQANRGRPMAFMSMFREINCALSCRTF 668724
668723 FGDYISQKAVKRIADDFYLATAALELVNIPLSMYIPFTKTWLGKRTADAVHVEFAKCAAA 668544
668543 CKANMATGAKPTCIVDHWVLHMMESKRYHERVAAGETDVEKPTNLIREFTNEEIGETLFT 668364
668363 FLFASQDASSSATTWLFQILAQRPDVLDRLREENLAARGGDRNRPFDLPMLESLSYTNAV 668184
668183 IKELLRHRPPVIFVPYLATKNFPVTPDYTVPKGSMVIPSCWPALHDPDVYPNPEVFEPER 668004
668003 WISGDAESKTKNWLVFGAGPHECLAKRYVPLSMAAMIGKAALELEWTHHATEKSEEIRVF 667824
667823 ATLFPM (0)
DGCQLVFSKRV* 667698
CYP61A6 Fusarium oxysporum
96% to CYP61A6 Gibberella moniliformis
See the fungal pages for seq
CYP61A7 Aspergillus niger
JGI gene model estExt_fgenesh1_pm.C_40133|Aspni1
74% to CYP61A5
See the fungal pages for seq
CYP61A8 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
93% to P450-10_var1
53% to CYP61A3 S. pombe in CYP61 family
See the fungal pages for seq
CYP61A9 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
50% to CYP61A3 S. pombe = CYP61 C-22 sterol desaturase
See the fungal pages for seq
CYP61A10 Aspergillus terreus NIH2624
NW_001471411.1 AAJN01000002.1
72% TO 61A1 A. ORYZAE, 55% TO A. TERREUS 61A6
70% TO CYP61A1 Aspergillus niger
70% to CYP61A1 Aspergillus terreus
55% to CYP61A6 Aspergillus terreus
formerly CYP61A1, but a better match was found in A. terreus to CYP61A1
247642 MDFISKNTSPIIQKFQSPGIVAIFGSDISIWMVLLTVLITAVVYDQ (1) 247780
247843 FKYIRLKGTIAGPSWKIPFMGPFLESMDPKLEGYMAKWRSGELSCVSIFHK (2) 247997
248055 FVVIASTREMSCKIFNSPMFVKPCVVDSAHKLLGKDNWVFLDGKEHVDFRKGLNLLFTR 248228
248229 SALACYLPRQEEVFDMYFERFVARSAANNYKPLPWMPEFRKLMCTISCRTFVGHYISESA 248408
248409 LDKIAHDYYLITAALELVNFPIVLPFTKSWYGKRAADMVLREFSQCAAKSKLHIASGGEI 248588
248589 TCIMDAWVKAQLDSAAYRKNVAAGIPCEKPSHLLRDFTDYEIAQTVFTLLFASQDAN 248759
248760 SSAITWLFQIMADRPDVLDKLREENLRARNGDCNARLSMELFDKLPYTRAVVRETLRYRP 248939
248940 PVILVPYIAKKDFPITEKYTIAKGSMVLPSIWPATHDAEAYPNPDSFDPDRWITGTAEQH 249119
249120 PKNFLVFGTGPHYCLGQTYVQMNLMAIIGKASLALDWKHHITPDSEQIKVFATIFPQ (0) 249290
DDCLLTFRRQPGS*
62A Subfamily
CYP62A1 Aspergillus nidulans
GenEMBL U34740 L39121 (9392bp)
Brown,D.W., Yu,J.H., Kelkar,H.S., Fernandes,M., Nesbitt,T.C.,
Keller,N.P., Adams,T.H. and Leonard,T.J.
Twenty-five coregulated transcripts define a sterigmatocystin gene
cluster in Aspergillus nidulans
Proc. Natl. Acad. Sci. U.S.A. 93, 1418-1422 (1996)
gene stcB
CYP62A1 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
complement(join(62552..62810,62866..64025,64093..64200))
gene="aflV
69% to CYP62A1 of Aspergillus nidulans (ortholog)
note the earlier 62A1 sequence is missing some internal amino acids
CYP62A1 Aspergillus oryzae
GenEMBL BAE71332.1, BAE59529.1, BAC20333.1
66% to CYP62A1 Aspergillus nidulans, ortholog
MTNTASRELIRAIEHVPLTWWFLAVGGAWIVSKIVKILQTAYFSPLRKVPGPWYARLTSARLAWASFANN
RIYYVQSLHEKYGPIVLIGPEEVDIADPVAAKQIHRMGSGFVKAPFYKLLSPGPVDNIFNFRDAKLHSTR
RKLYAKGFTLNSLRQQWEPTIRNIVALTVERIRHDAQQGEAEILGWWTLMANETVCKLTFNGGHDTVRNG
TKDPFVLMLERRMGDLAHLLQHFAPPLYYLGRLLGRAEPRLHDVFFSQETMFEAGKHVVAIARSARDAEG
DRNLFVKALAAGDLESKIGCLNDTEIITDAGALLLAGSDPTALSLTYLIWCVLNRPKLQADLESEVAGLQ
GDITDAACADLPTLNAVICESLRLYGPAPGSMPRSPPPDGATLCGYYIPPSAVVVTQNWSLHGNPKVWKD
PHTFDHTRWLPGSSLSEEAKMSFNPFGQGARQCLGIHLGWMQLRLATALFFRRCPGAKLAPSTTPESMVM
IDSFIAGMPKARRCAIQL
CYP62A1 Aspergillus flavus
99% to CYP62A1 Aspergillus oryzae
See fungal pages for sequence
CYP62A1 Aspergillus nomius
AY510454
complement(join(68188..68446,68501..69660,69727..69834))
gene CypX of aflatoxin biosynthesis
92% to CYP62A1 Aspergillus flavus
MINTPPRDLIRAIEQVPLTWWFLTVGGAWILSTIVK ILQTAYFS
PLRKVPGPWYARLTSARLAWASFANNRIYYVQSLHDKYGPIVLIGPEEVDIADPGAAK
QIHRMGSGFVKAPFYKLLSPGPVDNIFNFRDAKLHSNRRKLYAKGFTLNSLRQEWEPT
IRNIVALTVEKIRHDAQQGEAEILGWWTLMANETVCKLTFNGGHDTVRNGTKDPFVLM
LERRMGDLAHLLQHFTPPLYYLGRLLARGVPRLHDVFFSQEMMFEAGKSVVAIARGAR
GGEGDRNLFVKALAAGDFESKIGGLNDTEIITDAGALLLAGSDPTALSLTFLIWCVLN
RPKLQAELESEVAGLPEDITDAACAELPIMNAVIHESLRLYGPAPGSMPRSPPPDGAT
LCGYYIPPSAVVVTQNWSLHGNPKVWKDPHSFDHTRWLPGTSLSEEAKMSFNPFGQGA
RQCLGIHLGWMQLRLATALFFRRCPGAKLAPSTTPETMVMIDSFIAGMPKARRCAIQL*
CYP62A1 Aspergillus ochraceoroseus strain SRRC 1432
AY092402.3
join(18386..18418,18503..19650,19718..19979)
gene StcB/AflV in aflatoxin/sterigmatocystin biosynthesis
80% to CYP62A1 Aspergillus nidulans
N-terminal exon modified to be more like Podospora anserina EST CU876063
MDFFTSLGSTQWLSILVYVGGLWLLVKVFQVSL (0)
TLRIAYFSPLSRIPGPWYARLTGLRLSWSVFAN
NRIHYVHKLHQDYGPIVRIGPQEVDVADPALGREMHRMGSGFTKAPFYALLSPAPVDN
IFNFRDAKLHAARRKLYAREFTLQSLRKEWEPTIREITKMTVQRIKHDALNGEAEIMG
WWTLMANEVVCRLTFGGGAGTVAKGVKEPFVLMLERRMGDLAHLLKHFAPPGYYLGRM
LAHVIPQLHDVFYSQEKMFAAGGGVVSRARAVKRDGDDSGPSNLFNKALEAGSLTDTD
IITDAGALLLAGSDPTAISLTFLLWCVLSRPQIQHEVEAEVAQLEGEITDAACEGLPI
LNAVINESLRLYGAAPGCMPRSPPPGGATLGGYFLPADTVVVTQNWSLQRDPNIWENA
HSFDHTRLPREIRMTEQAKIAFNPFGHGARQCLGIHLGRVEMRLATAIFFRECAGARL
SESVTEESMQVVDSFIAGVPRDRRCTIRLG*
CYP62B1 Fusarium graminearum
FG05806.1 AACM01000233 FGcontig1.233_scaffold3
See fungal pages for sequence
CYP62B2 Nectria haematococca (Fusarium solani group)
Necha1/scaffold_23:519115-520695
66% to CYP62B1 Fusarium graminearum (probable ortholog)
See fungal pages for sequence
CYP62B3 Fusarium oxysporum
76% to CYP62B1 Fusarium graminearum
See fungal pages for sequence
CYP62B3 Fusarium verticillioides
90% to CYP62B3 Fusarium oxysporum = ortholog
See fungal pages for sequence
CYP62B Fusarium sporotrichioides
fragment BI188839 EST 88% to 62B1
PRVVPGKGATLAGHYLPAGTVVSTQAYTVHRDESIWPNALRFDGYRFMDKSRVTATQKSA
LSPFGAGSRV
CIGMHLAYMELRLGAALFFRECRGVKLGVEMTDEMMAMENHFLIAPKAHKCMVKL*
CYP62C1 Aspergillus nidulans
AN6414.1 49% to 62B1 53 clan
See fungal pages for sequence
CYP62C2 Aspergillus flavus NRRL3357
GenEMBL AAIH01000225.1
63% TO 62C1
1 AA diff to Aspergillus oryzae CYP62C2
MEWQIYLGIAFALWIVQ (0)
958 LYTAFTSPLRRVPGPLYTVLTRLPLKLASLTGNRIYFVHELHRKYGPIVRIAPDDVDISS 1137
1138 LAEFREIHRAGSPFLKSKWYEKFVPSKRSGVFTMRDPKEHAARRKLFARPFSKSELRRT 1314
1315 WEPAVREKVQLAVSQIQRELKAVGKSDLLKWWTFLATDVSGQLMFGESFNMLQLGK (0)1482
1535 KNQYINVLESTMMGSGIGAELPLVAWLGRHIPLSSFQNMFRATDYLFQYGQRAVTNSRTT 1714
1715 SNASRNIFAGMVYESEKGDGIITDEEVVLEAGNLIVAGSDTTAITLTYLIWAVLSQP 1885
1886 KLQRELEEEVNSLSADFDDSALEELPLLNAVIMEALRLYGAAPGALPRETPEGGAKFCGY 2065
2066 FIPQGMTVTTQAYSIHRDGDIYPDPERFDVSRWLKTETSASELAKKAFSPFGAGGRICLG 2245
2246 IHLAWMELRLATAQFFRECAGVRLAPSATWENMRPVNYFLISPRGHQCEVECNY* 2410
CYP62C2 Aspergillus oryzae
GenEMBL BAE55279.1, AP007151.1
475900 MEWQIYLGIAFALWIVQ (0) 475950
476022 LYTAFTSPLRRVPGPLYTVLTRLPLKLASLTGNRIYFVHELHRKYGPIVRIAPDEVDISSLAE
FREIHRAGSPFLKSKWYEKFVPSKRSGVFTMRDPKEHAARRKLFARPFSKSELRRTWEPAVREKVQLAVS
QIQRELKAVGKSDLLKWWTFLATDVSGQLMFGESFNMLQLGKKNQYINVLESTMMGSGIGAELPLVAWLG
RHIPLSSFQNMFRATDYLFQYGQRAVTNSRTTSNASRNIFAGMVYESEKGDGIITDEEVVLEAGNLIVAG
SDTTAITLTYLIWAVLSQPKLQRELEEEVNSLSADFDDSALEELPLLNAVIMEALRLYGAAPGALPRETP
EGGAKFCGYFIPQGMTVTTQAYSIHRDGDIYPDPERFDVSRWLKTETSASELAKKAFSPFGAGGRICLGI
HLAWMELRLATAQFFRECAGVRLAPSATWENMRPVNYFLISPRGHQCEVECNY
CYP62C3 Aspergillus niger
JGI gene model estExt_fgenesh1_pg.C_150110|Aspni1
67% to CYP62C2
See fungal pages for sequence
CYP62D1 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_70000012
Necha1/scaffold_70:35727-37407
43% to 62B1, 43% to 62C1, 37% to 62A1
See fungal pages for sequence
CYP62E1 Phaeosphaeria nodorum SN15
GENEMBL AAGI01000353.1
46% TO 62C1, 46% TO 62B1, 42% TO 62D1, 39% TO 62A1
MAFVDVVTANKPLLVALI (0)
FVYVGLTCPTRHLPGPWYTRFTHYRLKRAVVTGQRIFYIDALHKQYGPIVRLSPTEV 956
GVADLDAFKEIHKIGTKYMKSEWYLRLANFPKAGVFTMLDPREHGARRKLLSRSFSRSY 1133
LVENWEPAVREKALLVVTKIKVDAMQSTADVYNWWMLLASDVSAHLAFGESFRMLETGH (0) 1307
ANQFIRVLKKLTMGAGIMVEMPFLRLLRFVPINAVQEMFNANEFILTGAGRAVEMARSRT 1542
GESNIFAKVIEDCEKEGEGHIDDMDVRIEAMNIIIAGTDTTGVTLTYLTWAVLQQPQ 1713
LQSALEVETAGLRENFTESDLINLPLLNATIEETLRLYGAAPSSLPRVVPQGGTRFSGHY 1893
IPQGVTVDTQAYTFHRDPRIWSDPLTFDPQRWISSQEGYTAEALSPDAKTAFHPFGVGAR 2073
SCIGIHLARMELRYAVAFFFRECRGIRLAPSTTLESMEFENFFLIAPKAHRCDITFQQ*
CYP62F1 Mycosphaerella fijiensis
JGI gene model e_gw1.7.207.1 revised at N-term
40% to CYP62B2 Nectria haematococca
41% to CYP62B1 Fusarium graminearum
See fungal pages for sequence
63A Subfamily
CYP63A1 Phanerochaete chrysosporium (white rot fungus)
GenEMBL AF005475 (208 amino acids)
Kullman,S.W. and Matsumura,F.
Identification of a novel cytochrome P-450 gene from the white rot
fungus Phanerochaete chrysosporium
Appl. Environ. Microbiol. 63, 2741-2746 (1997)
CYP63A1 Phanerochaete chrysosporium (white rot fungus)
No accession number
Jagjit Yadav
Submitted to nomenclature committee Dec. 15, 2000
Clone name Pc-1
Aside from intron editing, this sequence and AF005475 have only
10 aa differences clustered in one region and are probably
the same gene
JGI gene model ug.20.36.1
MGLTQAQRLVLGQLARLVAPALAVCVLLAAARRTQLVRAPVWADALIALIAIPLFHVGRA
HWRYARLARKAARLGAALPPRWEGKLPGSVDVLQLVDEAYRRGFLSDYFYEKFGELGHTY
NFYVLWDMDYCTEDAAVIKAVLATDFNNWVKGERFDSYMHSVLGTGVFNADGELWKFHRS
MTRPFFARERITDFETFNRHAEEAILKMKERLREGFAVDFADLISRFTLDAATEFLFGAC
VHSLAGALPYPHGAPAHLHTTRARIPADDFAAAFRAAQDAVSHRARLVWLWPWFELARSR
TDTPMRTVDRYLTPIIERALAMSRAAKQAPQGEKEEVADGETLLDHLARYTTDPTILHDE
ILNIMIAGRDTTGGTLTFVIYFLTQHPDVLQRLRQEILDVVGPSNLPTYDDIKQMKYLRA
VLNETQRLYPPVPWNMRYAVEDSIVPNSEPEGKPWFIPAGASVSYSVHCMHRRKDYWGPD
AEEFDPDRFLDERLHKYLTPNPFIFLPFNAGPRICLGQQFAYNEMSFFLVKLLQTFEDIS
FERDAFEPNALPPAEWAKFPGRKGKEKFWPRAHLTLYSEGGMWVKMREAQAMGQVA
CYP63A2 Phanerochaete chrysosporium (white rot fungus)
No accession number
Jagjit Yadav
Submitted to nomenclature committee Dec. 15, 2000
Clone name Pc-2 JGI gene model ug.20.35.1
85% to 63A3, 59% identical to 63A1
MLVSVDALALRTLVYELTYLLYPAVPTAAALILLQRFGNVWLPTWTIVLLSLCNVPVAHR
ILVWLKDGRAARKAASMGAILPPRLKGRWPGSIDLLRQLTQTFETGFLSEMLWGYMHVLG
QTFEVYILWDSNYVTSDANVIKTILATDFDNFVKGEKLDVCVRPVLGTGVFNSDGEMWKF
HRSMTRPFFTRERISHFDLFDRHADATMAKMKARLAEGFAVDFQDLISRFTLDSATEFLF
GQCVHSLASVLPYPHDAPAHLQTTGASRTEDFARAFAEAQDAVSFRLRMGWLWPWFELFG
SRTKAPMAVVDAFLDPILRDAVARADKIKRENGGRVPEVKGEIEEDETLLDHLVNVVQTK
ILHDEVLNIMIAGRDTTGGTLTSAVYFLSQYPEVLRRLREEILEKVGPTRRPTYDDIREM
KYLRAFINETLRLYPAVPWNVRYPVKDTTIPGPHPDKPYFIPANTPVSYSVHCMHRRTDY
WGPDAEAFDPDRFLDARVQRYLTPNPFIFLPFNAGPRICLGQQFAYNEMSFFVIRLLQHF
DEVQLCEDALAPDCRVPDAWRGAPGRKGVERFWPKAHLTLYAKGGLWVKMREASTSEAVV
CYP63A3 Phanerochaete chrysosporium (white rot fungus)
JGI geme model ug.20.34.1
MPSSIDFPDRLVLRVIAYELVFLFYPAVPAAAGLVLLRRLTDIWLPTWAIVLLSVCSLPVVHGLSIWR 26138
26137 NHWRAARKAARMGAVLPPRLKGRWPGSIDLLMRLTDAFETGFMS (1) 26006
25949 DLLWEYMHTIGQTFEVYVLWDSNYVTSDANVVK (0) 25851
25697 AILATDFTSFVK (1) 25662
25698 GKKFDVCMRSVLGTGVFNSD (1) 25639
GDMWK (2)
FHRTMTRPFFTRERISHFDLFDRHA (1) 25433
25379 DDAMAKMKARFAEGYAVDFQ
DLISRFTLDSATEFLFGQCVHSLASVLPYPHNAPAHLQ 25206
25205 TTSASAAEDFARAFAEAQTVLNFRIRMGWLWPWFELFGSRTKAPMAVVDAFLDPILKAAV 25026
25025 ERADQIKHENGGKVPEAKEEIDEDETLLDHLVKYTN (1) 24918
24855 DPKILHDEVLNIMIAGRDT (0) 24805
24748 TAGTLTSAVYFLSQYPEVLRRLREEILEKVGPTRRPTYDDIREMKYLRAFIN (1)
ETLRLYPAV (2) 24515
PWNVR (2)
24380 YPVKDTTIPGPEPDKPYFIPANTP (2) 24318
24258 VSYSVHCMHRRTDYWGPD
AEAFDPDRFLDARVQRYLTPNPFIFLPFNAGPRICLGQ 24091
24090 QFAYNEMSFFVIRLLQHFDEVQLCEDALAPDCRVPDAWRGAPGRKGVERFWAKAHLTLYAK (0) 23908
GGLWVKMREAPTSEAV* 23800
CYP63A4 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.151.16.1
PC-4
MALPPGLQYLLPQLPLLLAPPAAVLLAAHAARAFAGTAAPAWALALACVLSWPVALTALV
QLRAHRVAREAAARGARLPPAVEARYPGGVDLMRRNNSEVEEHIPGYRLSEFGRQYGWTY
NFRMLFQDRVRGRPRPRPPGRILATDFTSYEKGAVFSAQMKSLLGTGVFNADGDLWKFHR
AMTRPFFSRDRISHFDVFDRHAEDALKLAKARLSEGVPIDWQDLVSRFTLDSATEFLFGQ
DVRSLSAPLPHPPTAPQAQHDTHDAEHPANRFAHAFLQAQLASARRSRYTAAWPLWEFWE
NKVEKHTRVMDEFIQPLLRDALARKAKGADAQAEEAVADGETLLEHLVKLTDDPQIIHDE
TLNILLAGRDTTAITLTMAGYMLAEHPDILQRLRKEILDTVGTRRPTYDDIRDMKYLRAF
INEVLRMYPPVPFNVRFSTAPTVWPSPEGDFYVPAGTRCMYSVFVMHRRKDLWGPDADKF
DPDRFLDERLGKYLTPNPFIFLPFNAGPRICLGQQFAYNETSFMLIRLLQRVSKIELHPE
VSPQSVAPPGWAASSISDGKDKVVFKSHLTMYVQGGLWVTMQFENPEEH
CYP63A5 Postia placenta (brown rot basidiomycete fungi)
CYP63A6v1 Postia placenta (brown rot basidiomycete fungi)
CYP63A6v2 Postia placenta (brown rot basidiomycete fungi)
CYP63A7 Postia placenta (brown rot basidiomycete fungi)
CYP63A8 confidential basidiomycete
CYP63A9 confidential basidiomycete
CYP63A10 confidential basidiomycete
CYP63A11P confidential basidiomycete
CYP63A12 confidential basidiomycete
CYP63A13 confidential basidiomycete
CYP63A14 confidential basidiomycete
CYP63A15P confidential basidiomycete
CYP63B1 Phanerochaete chrysosporium (white rot fungus)
JGI geme models genscan.57.18.1 and genewise.57.16.1
PC-7
MPHPFSRYRLRVFGDFVRIVLAPSFVFWSAVQILKLRLGLLSPAAWLTFLFAASYARVQY
RGFLQRQEARRRGGVLPPEVVGRWPGNIDILIKLGKASLTAYPGSFYLDLFEEYQSTTLN
LKLLWSDLVRCLSFCRLSAVLKTLSQIITMDEEHIKHILTTGFNHFWRGRRQKERMYAPS
GASRRHDTDSQGDVSQEWKKHRALARPFFARDRISDFDLFEKYAGATLGILGGLAGRGAA
VDVQDLYARFTLDAAAEFLFGERLDTLHGALPVAGQAKLGSKGAATDDAFGAFVRAFEAS
QDIITTRQVRGYFWPVRELFQDKVAPHAAVIGAFLEPIVQRTLDRKAKMRAAGVSPTTEH
DTFLDYLADHTEDPKVIRDQLLNILMAGRDTTACLLTYVTYVMAMYPDIMQKMRQEVLHV
CGHDAPNFEKLKALRYVHAVLNETLRVFPPVPMNVREVRARGVVLPHADPTYAAAPAPLY
VPGGTVVMYLPVLTQRNTALWGDDADVFDPDRWLDARLRRFTENPMMYTPFSGGPRICIG
QNYARNEATYLLVRLLQQFDAVALAPEAQPAGSLPPPEWRHARGRAAEERIWPAYAITLY
VKVRLSLQWLYC
CYP63B2 Postia placenta (brown rot basidiomycete fungi)
CYP63C1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.101.32.1
PC-5
MELHPRQYRLRFLLDVLRAIVWPQLVFNAALYLAGFHPGAFLRVVASVLAVPLLGTVRTA
ISQRRNKIQAGAALGAKEVPCVRGKWPGNLDIVLGFVRSLKEAYLMQFLDDLFREYDCKT
LNMRLLWEDQIWTIDEAHVRYMLAGPGFEWFHKGYYWQERMESFLGNGIFNRWAQRAIAR
PWFVKDRISDLNIFDRHTTTTLALISEFVDRREAFDAQDLFARFTLDSASEFLFGRCLDT
LHGTLPVAGRAKMGPKGTAIEDAFGSFARAFEDVQVQIARRTRIGKPWPLFELFTDKTAP
SVAVIHDWLRPIVHEALAKKSAASAEKESGEDSTFLSHLANSTDDPQDIAYSVLNMLLAG
RDTTASVLSFVVYFLALHPHVTEKLRAEILQAYGPDGRPSVEDMKDLKYVRAVLNETMRL
FPPVPMNLRLSDAHPRIFPASGSAPKYYVAPRTVILYSIFLVQRRTDLWGADALEFRPER
WLEPATARLLADHPFAFTPFHAGPRLCLGQNFAYNEMTFFIVRLLQRVSGFELAPDAQPE
GSLPPARWKYGEGRQAVEKIWPASSVTTFIKVSLASMPCCGERWLKRRRQGGLWVRAVPA
CYP63C2 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.101.28.1
PC-6, partial only 387 amino acids, needs more work
QRAIARPWFAKDRISDLNIFDRHTSTTLALIADFADRREAFDAQDLFARFTLDSASEFLF
GKCAETLHGTLPVAGRAKLGPKGSSVEDEFGSFAWAFEELFHDKTAKHRKVIQDWLQPIV
REALHSKAAAARGEDTGEGTFLSHLTKTTDDPQDIAYSILNMLLAGRDTTAAALSFTVYL
LALHPEVVEKLRAEVVQAYGSDGRPSVEDMKSLKYLRAVLNETMRLFPPVPLNIRTSDDT
PRVFPASAGAPKYYVPPRTPVVYSSVIIQRRKDLWGADALDFRPERWLEPETARRLAENP
FMFMPFHAGPRLCLGQNFAYNEMSFFVVRLLQRVAALELAPDAQPEGSLPPARWKNGEGR
QAVEKIWPGSSVTTYIKVSSTRSRPCG
CYP63D1v1 Postia placenta (brown rot basidiomycete fungi)
CYP63D1v2 Postia placenta (brown rot basidiomycete fungi)
64A Subfamily
CYP64A1 Aspergillus flavus
GenEMBL U81806(2760bp)
Prieto,R. and Woloshuk, C.P.
ord1, an oxidoreductase gene involved in the conversion of
O-methylsterigmatocystin to aflatoxin in Aspergillus flavus
unpublished
CYP64A1 Aspergillus parasiticus
GenEMBL AF017151
Yu,J., Chang,P.K., Ehrlich,K.C., Cary,J.W., Montalbano,B.,
Dyer,J.M., Bhatnagar,D. and Cleveland,T.E.
Characterization of the critical amino acids of an Aspergillus
parasiticus cytochrome P-450 monooxygenase encoded by ordA that is
involved in the biosynthesis of aflatoxins B1, G1, B2, and G2
Appl. Environ. Microbiol. 64 (12), 4834-4841 (1998)
97% identical to Aspergillus flavus CYP64A1 (0rtholog)
CYP64A1 Aspergillus parasiticus aflatoxin pathway gene cluster
GenEMBL AY371490
join(57543..57738,57815..57944,58000..58191,58256..58407,
58457..58701,58759..59030,59089..59488)
gene="aflQ"
function="conversion of O-methylsterigmatocystin to
aflatoxin B1 and aflatoxin G1 and
dihydro-O-methylsterigmatocystin to aflatoxin B2 and
aflatoxin G2"
CYP64A1 Aspergillus oryzae
GenEMBL BAE71330.1, BAE59527.1
99% to CYP64A1 Aspergillus flavus
MIYSIIICAGALLGLWILEKLLAPKDTRPPLPPGPWRKPIIGNLTDFPPKGTPEWLFWAKHQERYGPMSS
LEVMGQTIIMINDAQLGIEIMHKKSALSQMIPDAPFAHMAGWGMSLATERNRQAWKTIRANMKQEIGTRR
AISTFHSKMEIGIRRFLLRTLDNPDDLRFHIRKEANAFMMDVAYGYTIAPHGKDELYDLTQQSVRQFSHI
FSPGEWSVNFFPILRYVPSWFPGASFQIKAAEYKWTIERMTMVPYLWIKDQVARGCSRPSILLRLLQKGH
YESGSHQEQVLVWTNAEFVMGGSDTTVSAVSSLFVAMALYPEVQRKAREELDRVVGPTTLATFEHRSQLP
FIDALVKEVFRWHPASPLGAPHITQEDQIWDGYLLPKGALLLPNIWTFTHDPSVYHDPMVFKPERFLEGK
DSPPETDPMKFVFGFGRRICPGRFVTDEKLFLIACHAVSCFFISPKDPGAPEPDWLPGVISQPGTFDLNV
VPRSPAHEELIRSIETDHPWKNADATDISRFMARNQMI
CYP64A1 Aspergillus nomius
AY510454
join(63157..63352,63429..63558,63614..63805,63870..64021,
64071..64315,64373..64644,64705..65104)
gene OrdA of aflatoxin biosynthesis
93% to CYP64A1 Aspergillus flavus
MIIGLIICAGALLGLWLLEKLLAPKDTHPPLPPGPWRKPIIGNL
TDFPPKGTPEWLFWAKHQGRYGPISSLEVMGQTIIMINDAQLGIEIMHKKSALSQMIP
DAPFAHMAGWGMSLATERNKQAWKTIRANMKQEIGTRRAISTFHLKMEIGIRRFLLRT
LDSPDDLRFNIRKEANAFMMDVAYGYTIAPHGKDELYDLTQRSVRQFSHIFSPGEWSV
NFFPILRYVPSWFPGASFQVKAAEYKRTIEKMTMVPYLWIKDQVARDCCRPSVLLRLL
QKGHYESGSQEEQVLVWTNAEFVMGGSDTTVSAVSSFFVAMALYPEVQRKAREELDRV
VGPTTLATFEHRSQLPFIDALVKEAFRWHPASPLGAPHITQEDQIWDGYLLPKGALLL
PNIWAFTHDPSVYQDPMVFKPERFLEGNGSPPETDPMKFVFGFGRRICPGRFLTDEKL
FLLACHTLSCFLVSPKDPAAPEPDWLPGVISQPSPFGLNVVPRSPAHEALIRSIETDH
PWKNADATDISRFMARNEMI*
65A Subfamily
CYP65A1 Fusarium sporotrichioides
GenEMBL AF011355
Alexander, N., Hohn, T.M., and McCormick, S.P. (1998)
The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome
P450 monooxygenase required for C-15 hydroxylation in trichothecene
biosynthesis.
Appl.Environ.Microbiol. 64(1), In Press
The TRI11 gene catalyzes the hydroxylation of isotrichodermin to 15-
decalonectrin
submitted to nomenclature committee
CYP65A2 Fusarium graminearum
FG03540.1 AACM01000159 FGcontig1.159_scaffold2
See fungal pages for sequence
CYP65B1 Neurospora crassa
AABX01000364.1 cont3.489
Neurospora crassa sequence contig 1.742 (supercontig 102)
42% to CYP65A1
MNLSHLLPLGIPLPSPTSLIGIFLIG (0)
TSILVSSILLSAIYNLTLHPLARHPGPFFHRASILPYLYRQITGTLPCSILDFHARYGPVVRISPNALSFADPQAWKDIY 26703
26702 GHRPHGEEEFAKLNLFYRIKGSPPSLLSETKEAHGTLRKLMAHGFSDRSMRAQEGIIGGYVK (1)
EEQDERVPLDMVSWYNWTTFDIIGDLAFGEPFGCLEKAEYDPWVDAVGKSVRFGCVMFA
LRLLGLEDWVCPLVRKLSGNARRFHRKRTMDKLQRRVKLTKERPDFLEGLLQKREEW (0)
GIDMDALAANASLLIVAGSETTATLLAGATYMLLRDPEAMKKLTEEVRSTFKSEEEITL 25711
25710 SSVGNLEYMLACLNEAMRLYPPVPIGMPRVVPKGGAKVAGTFVPEG (0)
TVVAVWHWATSHNEQHFVEPFEFHPERWMQDPRFANDRLD 25372
25371 AVQPFSVGPRNCIGR (2)
SLAIAEMRLILTKVVYNFDMKLANPEKDWLDQHIYTLWDKHPLPVYLTPIERNGV*
CYP65B1 Neurospora discreta
JGI gene model scaffold_9-snap.228.1
85% to CYP65B1 N. crassa
gene model does not appear to be assembled
correctly. One low complexity sequence
removed. mRNA may be needed to decide this assembly.
See fungal pages for seq
CYP65B2 Magnaporthe grisea
MG06544.4 55% to 65B1 new N-term AACU01000188 cont2.1218
See fungal pages for seq
CYP65C1 Neurospora crassa
AABX01000034.1 cont3.25
Neurospora crassa sequence contig 1.96 (supercontig 12)
45% to 65B1
MPVIDKLAGVTGLSGLHLLLGAVGVT (0)
ILLYIIGSAIYNVFFHPLASYPGPLLQRASPIPFSIRHALGVQPFHTQALHDKYG
PVVRIAPNHLSFTDVRAWRDIFGHIAGSRHGQEELAKFKS
FVRPIDAQPIHIISAGREKHGQLRRALANSFSDASMRGQGPLIGKYIDLLLHKLH
EQGQEGKVPLNATSWYNSVTFDVAGDLIFGMSFGALDQNGNHSWLQYILGSLSSLAPMAA
LSYAGLHWLVQLLWRAKGAEVFRKSMESVDLMLKERLKMPVDRNDLFEGLVQRQEKL (0)
GLSFEELASNAWLLVL (2)
AGADTTATTLSGTTYLLTQHPEVLKRVTQEVRSSFKSVEEIDISSVNRLTYMLAVLNEA 64919
64918 MRLYPPVTSLTARIVPRGGAHVLGEYLPEG (0)
64756 TIVDIQQWSMNHSKENWVDPWAFNPARFLDDKETAREKGNVLDALQTFSVGPRNCIGR (2) 64580
NLAYAEMRWILARILFDFDLRGAPTNQNWIERQKAYGLWDRIPLDVYFEPARERK*
CYP65C1 Neurospora discreta
JGI gene model estExt_Genewise1.C_41538,
gene model incorrect. Added I-helix
87% to CYP65C1 N. crassa
see fungal pages for seq
CYP65D1 Magnaporthe grisea
MG03832.4
47% to 65B1 partial seq. length 53916
runs off end, changed C-term AACU01001030.1 cont2.747
N-term on AACU01001031.1 cont2.748
seems to be missing some N-terminal seq.
see fungal pages for seq
CYP65E1 Magnaporthe grisea
MG03830.4 37% to 60A3 AACU01001030 cont2.747
see fungal pages for seq
CYP65F1 Magnaporthe grisea
MG08498.4 42% to 65A1 AACU01001266 cont2.1600
see fungal pages for seq
CYP65G1 Magnaporthe grisea
MG00023.4 39% to CYP65A1 41% to 65B1 AACU01001352 cont2.7
see fungal pages for seq
CYP65H1 Magnaporthe grisea
MG10954.4 39% to 65B1 40% to 65A1 41% to MG05390.4
AACU01001824.1 cont2.2124
see fungal pages for seq
CYP65J1 Magnaporthe grisea
MG10070.4 39% to 65B1 , 40% to 60A2 AACU01001328 cont2.1928
see fungal pages for seq
CYP65J2 Alternaria solani
Alt3 BAD83682 69% to 65J1 Mg
PKS for alternapyrone is next to three P450s called alt1, 2, 3
Chem Biol. 2005 Dec;12(12):1301-9.
1 MALSSALDSL WHQLDQLLSL INRNIITGII VLPVLYVLLK VIYNLYLSPL AGYPGPKLWA
61 VSRLPWNRAN MKGRISWKIR ELHDKYGPVV RIAPDELSYT TSGAWKKIYG QRNPEFVKAL
121 DGRGIAPASI GGQRSLMTEH QDKHLRLRRA IDPAFSQRAL REQESYFQDH SDNLVQKLKQ
181 RCKDGPLDMT TWYNLVAFDI VSDLAFGEPS GCVNNPDQPW IQAILARAKA IVWFQLAVQY
241 GFMGLLNWMT PKYVTESRKK HIAMTEAKLK ARVEAKNPGK DFMSYILEND EKLNHLELVM
301 LSSNFIVAGS GTSAGGMSGL TYLLLRNPDK LEKLKQEIRG LFKSRADMTL QAVTSCKYLR
361 ACLNEGMRLY PPTPGSLPRF VPGKGEMIEG KWVPGGYAVG VNQLAAGHSE RNFKKAREFH
421 PERWLDEPDS EFKDDDRSAV QPFSYGQRGC IGRSMAYAEM SLTMAKLVWY FDWELDEPDN
481 DWWNQQGTYL VWEKLPLQVK LTPVSDVVE
CYP65K1 Magnaporthe grisea
MG09945.4 poor match 41% to MG02982.4
AACU01001747.1 cont2.1897
see fungal pages for seq
CYP65L1 Magnaporthe grisea
MG02982.4 42% to CYP65B1 38% to 65A1 AACU01001589 cont2.600
see fungal pages for seq
CYP65M1 Magnaporthe grisea
MG00651.4 37% to 65B1 AACU01001445 cont2.120
see fungal pages for seq
CYP65N1X Magnaporthe grisea
Name changed to 563B1
see fungal pages for seq
CYP65P1 Magnaporthe grisea
MG07983.4 48% to 65B1 partial RUNS OFF END
AACU01000985 cont2.1482 C-TERM HALF
see fungal pages for seq
CYP65Q1 Fusarium graminearum
FG07765.1 AACM01000318 FGcontig1.318_scaffold4
see fungal pages for seq
CYP65R1 Fusarium graminearum
FG03191.1 AACM01000148 FGcontig1.148_scaffold2
see fungal pages for seq
CYP65R2 Fusarium oxysporum
82% to CYP65R1
frameshift at TLQ/KMH
see fungal pages for seq
CYP65R2 Fusarium verticillioides
95% to CYP65R2 Fusarium oxysporum = ortholog
see fungal pages for seq
CYP65S1 Fusarium graminearum= Gibberella zeae
GenEMBL AACM01000323
complement(join(168239..168404,168457..168623,
168682..168761,168816..169001,169050..169836,
169886..169960))
locus_tag="FG08023.1"
sequence revised added back GMSRPEIIENSSLLIV to gene model
MAIISTDLASGTSLGGGLVLLAAAVVLFVTGRAIYYVFFHPLAK
IPGPKLYAATQLPYLYHLTRGQWVYRLKELHEQYGPVVRYTYNDVSFITADAYKTIYG
HKTGGAREFGKDFRLYRQGRPAPSLIVTKHEDHKRQRKLLSHAFSHKALSEQNDLLMH
YVNLFIEKLTQKAREGESVDMVAWYNFATFDLIGHLALGQPFGCLESGKYHPWVTKIF
SSIKGISFSQAAIRLGLHNWISLITPAHVKKATKEHFEFTEHVAGARLDVKDNNSKDFMSYILRYNDER
GMSRPEIIENSSLLIV
AGSETTATLLSGVTYQLLTNPEAYKKLVTEIRLAFATEEDITAAAVD
KQTYLLAVLSEGFRMYPPVPGALGRTIPKGGDFVEGHWFPENVGVSVPQLPAYHSARN
FKDPEKFVPERWMDDPRYSNDCRAVVQPFSMGPRDCIGKNLAYLEMRLLLTRLLWKFD
AELMPESREWKEQKIFTLWEKGSLHVKLTEVVREKN
CYP65S2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.7.949.1 short on N-term
Necha1/scaffold_7:62397-63948
54% to CYP65S1 Fusarium graminearum
see fungal pages for seq
CYP65S3 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_4000060
Necha1/scaffold_4:143263-145075
56% to CYP65S1 Fusarium graminearum
60% to 65S2
see fungal pages for seq
CYP65S4 Fusarium oxysporum
58% to CYP65S1 Fusarium graminearum
see fungal pages for seq
CYP65S4 Fusarium verticillioides
94% to CYP65S4 Fusarium oxysporum
see fungal pages for seq
CYP65T1 Aspergillus nidulans
AN7522.1 38% to 65A1 53 clan
see fungal pages for seq
CYP65T2 Neosartorya fischeri NRRL 181
AAKE02000011.1
DS027697.1 complement(627606..628748)
57% to 65T1
MMFVILAAASLLYISYILLLAIKTIYFHPLSHIPGPKWRIGIPLLHHLS
628603 AIRGRLDLDISSWHEKYGDVVRSGPDEVTFITAQAWKDIYGHGHRQLPKVQISAINGKDI 628424
628423 FSANDVDHARFRKALSHAFSAKGLQAQERIVTQYIDKLIQRLKWFAESGTAADMGKW 628253
YNLATFDLIGDLAFGEPFGGLDSA
EYHHWVATMFGFVKSIPFLRALHRYPVVFKVILAFHPGSLMEMRSKQVEHAKATVQKRL
SNSAAGRGDFMDSMLRHQGDKGGLSLDELEENANVLILAGSETTAALLSG
VTYWLLRTPDALDKVMREVRAAFALERDITFNQVTAKLPYMLACLNEAFRLYPPVPGGLQ
RWTEVPTWISGYRVPAN (0)
TKVSVHQLSAYSSLKNFHQADRFIPERWLPEAIEDPASPFFSDNRAVFQPFSIGPRNCLG
RNLAYTEMRVILARVLWTFDLTLCEESRDWKDQKIFVIWERGPLMCKLAMRDDRGDCQGGR*
CYP65T2P Aspergillus fumigatus Af293
XP_748490.1 also AAHF01000010.1
58% to 65T1 Nterm aa 52-168 plus C-term part, 84% to 65T2
name revised from 65T3P
SLRGRLDLDLRSWHEKYDGVVRPGPDEVTFITAQAWKDIYGHGHLQLPKVQISTINGK
NIFATNDVDHARFRKALSHAFSAKGLQAQECLVTRYIDKRIERLKGFTESGTAADMGKW 425909
*NLATFDLIGDVAFGEPFGGLD
AYSSPRNFHQADRSIPERWLPQVIENPASPFFLDNRAVFQPFSIRPRNCLGRNLAYTEMR
MILARGLWTFXX
LCEESRDWTDR
CYP65T4 Aspergillus oryzae
GenEMBL BAE59716.1
68% to 65T1, 45% TO CYP65AF1
MPFNILLWPVIAFFLYSLLTAIWYIYFHPLRRIPGPKSWIIFPIMRHASAIRGRFDIDMRQHHAVYGPVV
RFGRDEVSFITAEAWKDIYGHGHQQLPKVLSSASNMLDIISSNDTDHSRYRKALSHAFSAKGLQAQEPLL
NSYVDKLIERLKGIAESNLPADMVKWYNLTTFDIIGDLAFGEPFGGLDNSEYHHWVSTIFESIKAIPFLK
LKDAYPLAFKAILGLIPKGIMEARKRQLEHSRITVQKRLQTSSSYNRGDFMDSMLRNRGEKDSLNDSELE
ANSNILIIAGSETTATLLSGATYWILRNPEALAKLTDEVRSVMKSEPEITAQKASAELPYMLACFDEAFR
LYPPVPTGLQRRTLVPTRISGCDIPAGTKVSVHQSAAYWSSTNFHAPDRFIPERWLPEAKSDPSSPFYSD
NRGVVQPFSTGPRNCIGRNLAYAEMRVILARVLWNFDLELCEESTQWSDQKAYTLWEKPPLMCRLKLRES
FRG
CYP65T4 Aspergillus flavus
99% to CYP65T4 Aspergillus oryzae
see fungal pages for seq
CYP65T5 Aspergillus terreus NIH2624
NW_001471196
68% to 65T4, 62% to CYP65T1
MALQEFLPVVPAISVLYIFLLAIWNLYFH
PLRHIPGPRSWIAFPIMRHISASRGRLDSDMRRFHAQYGGAVRLAPAEVSFITPDAWKTI
YGHGHTQLPKVQTSESKGLDIISSEGPNHTRHRKALAHAFSARGLQAQEPLVRGYVDKLI
ERLKEFAESQLQVDMVKWYNLTTFDLIGDLAFGESFGGLDNSRVHSWVSTIFRSVKVLPF
VRITDTYPILIPLLMALLPKSLRTARRDQTNYSKETVHKRLANTAAHGRGDFMDSMLRHR
GEKDGLSDRELEENASILIIAGSETTATLLSGVTYWLLRSPEALAKVTDEVRSTFQTEGE
ITLQDVGARLPYMLACLDEAFRMYPPVPCALERRVLTPIVIAGYNIPPG (0)
TVVSVHQSAAYCSPANFHRPQDYIPERWLPDAKSNPSSPYFSDQRDVLQPFSVGPRNCIG
KNLAYAEMRLILARVLWNFDLELCEESLHWKDQKSYLLWDKPPLMCKLKQRI*
CYP65T6 Aspergillus niger
JGI gene model e_gw1.4.330.1|Aspni1
65% to CYP65T4
see fungal pages for seq
CYP65T7 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_3000290|Aspni1
68% to CYP65T4
see fungal pages for seq
CYP65T8 Aspergillus clavatus
69% to CYP65T2 Neosartorya fischeri
see fungal pages for seq
CYP65 fragment Aspergillus ochraceus
DQ054597 C-term piece after heme signature
Involved in ochratoxin synthesis
See DQ054596 for a second P450 in this pathway
This fragment is 60% identical to CYP65T5 C-term
FLRAQGTASERNLAYAEMRLIAVKLLWNFDLAFEEECEGWDNQK
SYNIWEKDPLKVKLTP
CYP65U1 Aspergillus nidulans
AN6466.2 37% to 65B1 53 clan
revised 7/18/07
MGVYLFSSSLWATLLLAILIYRLVRITYNLYFHPLSGIPGPSAWAASRLP
FVYALIRGTIIQDFQKLHEQYGPIIRIAPNEVTFAHPEAYTDIFQPRPEK
SQGQFLKDPLWWARQPGHPDSLLSVINPERHAQMRRVLSPGFTARALRKQ
EPFVQKYVNLLVAQLQDLVSKSPSAHINMTPWFNYTTFDIFGDLGFGESF
DCLQHSRYHPWIALLFDSVKAAGFVIATRYYPLIEAVLLKCVPPSMRKIQ
RDHYQQIVDKVQRRLGWELQRPDFMSYVIDERGGLRLDAGELYATFMILT
TAGSETTATALTGTLNYLVNHSPESLQRLENEIRGAFSGLDAITLDAVRN
LPFLNAVIQEGLRLCPPIPWVLPRLVPQGGSMICGTWLPGGTPVSIQAYT
LNRDPTLFNRATSFLPERWLASSTSDSSSCFFNDQRQVVQPFSTGPRACL
GQHLAWAEMRLILAKLVWVFDFGAIDGQGVNWEDLRTYLLVERKPIN
VRISSRTV*
CYP65U2 Aspergillus niger
JGI gene model e_gw1.3.403.1|Aspni1
61% to CYP65U1
see fungal pages for seq
CYP65V1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.24.106.1 model short on N-term
Necha1/scaffold_24:57028-58643
49% to CYP65B1 N. crassa
see fungal pages for seq
CYP65V2 Aspergillus oryzae
GenEMBL BAE61720.1, AP007163.1
53% to 65V1, 43% to 65B1
revised 3/20/2009 with a frameshift = &
MMLNSINIPQNAISWAVACAAA (0)
198235 ATFCLASSVVYNIFFHPLARYPGPLSHAASRVPYFIRVFKGTLPFD
MLDFHTRYGDVVRIAPDELAFSHPDAWKDIMGHSKGGLYLEKASWFYRP
LEYDPPHIFNEGRQAHSLLRRQLAHSFSDKGMRDQEPMIRGYVDLLLQRLREMGGREDTVDISAWYNYTT
FDIIGDLSFGESFGCLKGSNYDEWIESIFRAFPFITALQALSFTPLVKEVLLALVPPSMRDRRERLRDFT
RQKMLRRMAIAEERPDLIEGLLKKKEEL (0)
GLTIDKLTA &
AETLVVAGSETTATLLSGVTYLLLKNPEAYQ 199191
RLREEVRSTFSSEDDINLSSAAKLPYMLACVEEALRMYPPGA
IGPPRVTPKGGAEILGARIPGRTYVSIHHWALYRREEYFTDPHTFHPERFLGDPRFSNDRHNVLQPFHIG
PRSCLGRNLAYSEMRLILALLFFNFDMELSDDSQDWIQQKNVIMWQRGPLKVHLTYIHRNSA
CYP65V2 Aspergillus flavus
99% to CYP65V2 Aspergillus oryzae
see fungal pages for seq
CYP65V3P Aspergillus oryzae
GenEMBL BAE55600.1, AP007151.1
Gene model has wrong C-term, revised
about 60% to CYP65V2, 48% to 65B2, 54% to 65V1
one stop codon and one frameshift in last exon
MSTAALVNAKSVLIATISA (0)
PIIYMLGMAIYNVYFHPLNRFPGPVSHAISRIPYFYRAVRGTLPFD
MLKLHERYGDIVRIAPDELAFSHPDAWKDIFGHKNGEPEMAKAAWFYRPLDDPLHIVNEDTDEHRRLRRQMAHGF
SEKSMRAQEPIIRKYVDLSLEKLHQSCKNGSLVILDWYNFTTFDIIGDLAFGEPFGCLEGCNYDQWIKGI
FKGAYLGSFMQALSFVPRLKSTLLLLVPKSMQEAHQGHKALTKAKMLRRAAITEKRPDLIDGLLRNKDEL
1455183 KLGLDKLIANAEILIIGGSETTASLLSGVTYLLLQNPNAYETLKNEVRSKFNHQEEIN 1455356
LISVNKLSYILA
CLDEALRMYPPIANGLPRVCPKEGSWVLGEYIPGKTVLSIHQWALYRREKHFKDPNTYHPERFLSSPEFL
DDRRDAFQPFHTGPRNCLGRN (2)
LAYS*MRLILALVIFNFDMRLPQRAKDWIRQRNYLMWDKGPLKVYLRPRTSI*1455965
CYP65V3P Aspergillus flavus
98% to CYP65V3P
see fungal pages for seq
CYP65V4 Aspergillus niger
JGI gene model e_gw1.11.216.1|Aspni1
70% to CYP65V3P
see fungal pages for seq
CYP65V5 Histoplasma capsulatum
ABBT01000064.1 Ajellomyces capsulatus G217B
55% to CYP65V4
see fungal pages for seq
CYP65V6 Aspergillus terreus
57% to CYP65V5
see fungal pages for seq
CYP65W1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.5.258.1
Necha1/scaffold_5:405215-406714
49% to CYP65B1 N. crassa
see fungal pages for seq
CYP65W2 Aspergillus niger
fgenesh1_pg.C_scaffold_14000165|Aspni1
53% to CYP65W1
see fungal pages for seq
CYP65W3 Metarhizium anisopliae var. acridum Ma102
CYP65X1 Aspergillus oryzae RIB40 genomic DNA, SC023
GenEMBL AP007157.1c, BAE58707.1
join(331674..331760,331832..332607,332687..333038,
333095..333264,333318..333474)
third P450 gene in a set of 8 on this accession
42% to CYP65S2, 40% to CYP65S3, 42% to 65A1
MALAAEYFSHALSQPYGSSFWVAVAASLVFICYITCDTVYNLCL
SPLSSFPGPRLWAVSNIPRQLSILGGRSHLKMLALHHRYGPVVRVGPSELSFNSPQGF
RDIYGFRRGQPQFQKDPKMYGSPLTGISNSIGGHVDSDTHSRHRRLLSHSFSERSLRE
QEGIVVYYVDLFIQRLRERTSVNKIHRAEEDLKSWFNFTTFDIIGDLMFAETFDCLKD
SQLHPWIALMFNNVKGIAFLGVLNEYSLFRKMQGALLPKALKQKMLENHKLCAQKADR
RLQKGASRPDFVSMQTQSCKHMGPLLFFFFMAANTDSITIAGSETTASLLSGCLFYLC
KHKYIMDQLNKEIRTTFSKDEEITSSKCFNLSYLNAVLKESLRLYPPVAASLLRLVPK
GGCTIDGHFVPEDVTVSTHHYASYRDAANFTFPEQFIPERWLGTDNRFDSDRKDVVQP
FSLGPRDCLGKNLAHMEMRLILSKLLFNFDIHLTPESENWGQQKMFIVWDKPALMVRL
TDRFA
CYP65X1 Aspergillus flavus
99% to CYP65X1 Aspergillus oryzae, 48% to CYP65AU1
see fungal pages for seq
CYP65Y1 Aspergillus fumigatus Af293
GenEMBL XP_746900.1
49% to CYP65V1, 88% to CYP65Y1 Neosartorya fischeri
revised 3/12/2009 added N-term, one stop codon
MGVGSDKG*VVCYVITQAVYNVFLHPLSRFPGPLLHRASRLAYVYRLIGGTLTLDALE
MHQRYGDIVRVAPDELFFAHPDAWSDIHKKTGREMDKAPWFYRPLEQSPRCIVDESHEQHSRLRRQMAPG
FSEKSMRDQEPIIRGYVDLLLQRLLEKSNDGQPVVISDWFNYTTFDIIGDLVFGEPFECLGSSKYDGWIK
SIFESLRPLTIVQALSFFPWLKRIALDTVPKNLQGDIKQQQQQTEAKMRRRMAVTASRGDLMEGLLKKKD
ELHLSTEELIGNAQVLILAGSETTASLLSGVIYLLLQNAVAYRQLVDEVRSTFNSEKDINFVSVSQLSYM
LACLNEALRIYPPVANGLPRVVPKGGAQILGQYIPEQTYVAIPQWALYHREQYFAEPNDFHPERFLGDPK
FANDRRDALQPFSVGPRNCLGRNLAYAEMRLILALVIFHFDMKIDPDCRDWIQQRNFTLWQKPPLKVYLK
PVARKSEPNQV
CYP65Y1 Neosartorya fischeri
88% to CYP65Y1 Aspergillus fumigatus = ortholog
see fungal pages for seq
CYP65Y2P fragment Histoplasma capsulatum G217B
C-term pseudogene of CYP65Y sequence 67% to 65Y1
ABBT01000195.1 Ajellomyces capsulatus G217B
see fungal pages for seq
CYP65Z1 Aspergillus fumigatus Af293
GenEMBL XP_751828.1
41% to 65R1 Fg, 44% to 65S3
MAPWNHDIFDRLMLSAILSWSILLQSQIANYRRRTLTRRQGCVYLIGHSIYAIYFHPLSRYPGPKIAAIS
PIALLVWEIRGKVHSKVKHLHDRYGDVVRIGPNALVYRAPRAWKEIYGYRTKKGQRTFQKDPSLYVPTPN
GVHAIITAAESDHIRMRRLLAHAFSDRALREQESLLHFYADLLVQKLHENLNHSHSEVVDIARWYNFTTF
DLIGDLAFGEPFQCLKDSKYHWWVSIMLDAVKLSVYLKVLWFFPILSPLTKLLVPRYLHQRREASFQLTV
EKVSRRLHRQTNRPDFISYILRHKDDENRMSRQEIDANAATFVLAGSETTAALLSGCTFYLLKNPHIYRR
LVTEIRSRFQHPSEIRLSSIATLSYLNAVLEESLRIYPPIPAMLPRLVPEEGAMINGEYVPAGTSVSMSL
WSTFHSSGNFHNPDSFVPERWLASPEEEASRCFTMDKKEAFQPFSYGPRNCLGQHLANAEMRLILAKVFW
HSDMELCPESENWADQESYNLWSRPPLMVMISRANGRNYEDNMV
CYP65Z1 Neosartorya fischeri NRRL 181 XM_001267015
94% to CYP65Z1
name revised from CYP65Z3
see fungal pages for seq
CYP65Z2 Neosartorya fischeri NRRL 181
XP_001260852.1
56% to CYP65Z1 Aspergillus fumigatus Af293
76% to CYP65Z5 Aspergillus clavatus
MSPISIVLSILVAVLLGQAIYNIYLHPLRKFPGPKLAACSNICY
IWWTISGEIHAKLKELHDQYGDVVRISPSTLVYRSASAWKDIYGHRKHGASSFIKDPE
YYIPSPNGGHILTAGDADHARQRRLLSHAFSEKAMREQESLVQHYVDLLVEKLRAECA
ASRSTVDMMKWYNYTTFDIIGDLAFGEPFDCLRDNRYHPWVKMVFQSVKMSVYLRLIH
LYPLLESLVKRLLPKKAAKMRNEHWRMSKDKVSRRLDLQTSRPDFMSCILRHNDERGM
TRQEIEANAGVLILAGSETTATLLSGCTFYLLKHPEKYNKLVQEIRGAFQKQDDITFL
SVARLPYLHAVLEESLRLYPPVPGYLPRKVPMGGASIDGQYVPGGVSVSVVPFSASRA
KSNFAEPESFIPERWLENRDRRFETDNREASQPFSFGPRNCLGKNLAYAEMRLIVAKL
LWNFDMTLHEDYRDWDDQTSYIIWQKPSLMVELKAVR
CYP65Z2P Aspergillus fumigatus
87% to CYP65Z2 Neosartorya fischeri
supercontig 2 3641455-3643345 region
see fungal pages for seq
CYP65Z4 Aspergillus clavatus
81% to CYP65Z1 Neosartorya fischeri
see fungal pages for seq
CYP65Z5 Aspergillus clavatus
76% to CYP65Z2 Neosartorya fischeri
see fungal pages for seq
CYP65AA1 Aspergillus fumigatus Af293
GenEMBL XP_749877.1
43% to 65S2, 40% to 65Z1
MSFLMESSAVGQPSPLSFSNTLNALPGALVLYAALHSLYNIYLHSLSRFPGPKLWQTSYIFRHIASIRGT
LDVSIKAFHTEYGPVVRYSPDELSFISAEAWRDIYGFRENALPKDPSFYGLIQLSRDKSPSIFTVDQDHH
PRVRKALSYAFSEKALHDQEPFVKHYVDLLIQRLRGIADAEDNRVDLVKWYNFTTFDIIGDLAIGRSFDC
LQDSAYHSWVDAFWKSIKMISPYARAMATYTDVPRLLRLFAPRALKEARLRRLQYVGVHMEERLARGILR
DKPDFISYILRSKGTADELTDGEVEANVSFLLLAGTETTATALSGTTYYLLKNPEGLRKATAEVRSAYNS
EDEITFATTAERLPYMQACLTEGLRIYPSGPIAAPRRTPRGTVTWIAGHPVPPVGGASNSPLNFHRQADF
IPERWLSPSTMDPASPFRRDNRAASQPFSVGPRNCLGKAFALNEMQVILARMLWNFDMKLLPQSDGWERQ
RIFTLWDKGPLMVELNEVRSSLHNQLFLQVCMVVCMVVHQSRSLQRAVHSSGPARNLTG
CYP65AA1P Neosartorya fischeri
NFIA_074000
C-term is missing
92% to CYP65AA1 Aspergillus fumigatus
downstream gene is a polyketide synthase
both genes are broken and fused at YNSE/PVEP
PVEP is about aa 410 in the A. terreus PKS gene XP_001215858
The high conservation (92%) suggests an assembly error rather than a
deletion creating a pseudogene. CYP65AA1 in A fumigatus is upstream of
a short PKS gene on AAHF01000007
CYP65AB1 Aspergillus oryzae
GenEMBL BAE56591.1
41% to 60A2, 39% to 60A5, 40% to 60B3
43% to 65S1, 40% to 65A2, 41% to 65B1, 44% to 65H1
47% to 65S3
Supercontig 5: 63753-65569 (+) strand
Revised 3/18/2009
MLFSLGPLTIVYGLVIFVVAKTIYNLYLHPLRSYPGPLLARATRWYYSYYVKIGLLPQKTKELHDQYGPC
VRIAPDELSYNTAEAWEDICGHRTGQRTESFEKDLTFFPPAPNGVDSI
IVAKDDVHRRFRRLLSHPMSDKA
LGSQQEIITGYVDQLIHELRQRSERSEVVDMVRWFNFTSFDILGDLAFGESFGCLGSGLMHPWIELIFTS
IKSVMDMQIIRRIPGLFSLILTIAGLQQKQDLQEQFMFCQKKARERYTKETTRPDFMTYILRATEEKGMT
PEEIEANAQILIMAGSETTASALSGTLFYLLKNSMAMQKLRQEIHATFQAEAEITMRSTQSMEYLHAVLQ
EAMRVYPPVPCTFPRTTPPGGAMVCGRFVPGGYIVGVNQLAAMTSEKNFKDPLKFIPERWCGDERYQEDS
RKAYQPFSYGPRNCLGKNLAYAEMRLVLTRLLWNFEFDLLEESKDWHAKQKVWMMWDKGDLKVRLKPLRH
CYP65AB1 Aspergillus flavus
Supercontig 8: 73235-75051 (+) strand
see fungal pages for seq
CYP65AB2 Aspergillus clavatus
82% to CYP65AB1 Aspergillus oryzae
see fungal pages for seq
CYP65AC1 Aspergillus oryzae
GenEMBL BAE59505.1 AY510452.1
58% TO CYP65AC2, 45% to 65U1
MSQFAREIVRNAIYNTSSPDADSVSLRKATTTVLLIGVT (0)
YCILVGIYRVTLHPLAKYPGPKLAAVTRLWHSYHLCTGDIVSVLSRAHEAYGPVLRIAPD
EVLFISSRAWDDIYGARPGKPE
MDKDTPLYKGPTAPHSIVTVDGELHRFYRRLLAKGFSDAALREQEPVIQRNINLLVEKLHKEVAAGKTPE
MTAWFNYATFDLIGELAFGETYGCLENSHYHPWVEMILEVMKLRAMTHAVGYYPWIFHILMWFVPKSLRE
KFVTHRRYTHDKVQRRMDQKIHYKDLTTNLVDPQNGLERYEIDGNCSTLIIAGSETTATALSATLYFLTQ
NENAKRKVIGEIRTTFNNAGDINSISVNQLKYLSACMNEALRIFPPGPAVFPRRVPQGGDFIDGHWIPGG
TQVGIAHYCINRSRRNFVDPDKFIPERWLGDPTYQTDDRHAVQPFSYGPRNCIAHNLARLEMRLVLARLI
WEFDWELAPGSERWEEEALVFNVWSTKPLMIKFTPVAR
CYP65AC2 Aspergillus oryzae
GenEMBL BAE54634.1, AP007150.1
40% to 60A2 (CYP60 is in the 65 family)
revised 3/20/2009
MTLSAESSQLPWALGNIVQQVHGIPIWGTVLTILVLVVL (0) HYAIYAVYNITFHPLAKYPGPKVAAMTRIVYTSHLLSGRLVEFLHQTHLKYGAVVGVAPN
EVIFTSSQAWNDIYNVRQGAPE
MSKDTPLYQSLGTPPTIAEAGHDLHRRYRRLLAKGFSEAGLREQEPVIQQKISVLIKQLHAATAKGTTPE
MTSWFNFFTFDLISELTFGESFKCQENGRFHPWILMVTQSIKFRAIIQALGYYPLLFKLFMGLIPKSYQE
AFRDHQKLTSENVQRRIDKKVDYTDLASNLIDPKHNLERYEIDGNCAVLIVAGSETTTTALSATMYYLTQ
NPEAKAKVIKEVRSSFSSAEEITAISVNQLKYLPACFNEAMRKLPPAPAVFTRRVPREGAYIAGNCIPGG
THVGMCHFATNNSSLNFKDPEKYIPERWLGDPEYEDDARAAMQVFSVGPRNCIGQNLARLELRLLLSRVI
WEFDWELDSASMDWDKDMPVYLSWGMKPLKFHFAPVVR
CYP65AC2 Aspergillus flavus
98% to CYP65AC2 Aspergillus oryzae
see fungal pages for seq
CYP65AC3P Aspergillus nidulans
67% to CYP65AC1 AN10101.3 (partial)
ETYGPILRIAPGEVLFTSSSAWDDIYGARPGKPEMDKXXXXX
KGPIAPHSIVAVDGELHRFLRRLLAREFSDVKLREQEPVNQRSINLLIEKLHDEVAAGKTPEMTAMFN
YATFDLIGELAFGETYGX
MENWRYHPWVKMIFYVMKLRALTHAVGYCSWVFPILXXXX
PQVLRD*FVVHRKYTTYDKVQRRKDRKIHYWELTTNLFDPQTGLER
XXXXXXXXXXXXXXXXXX
STALSATLYFLTQNEDAKRKVIGEXXXXXXXX
GDIKSISVTQX
KYLHTRVNETLQIFPPRSAVFPRRVPLGGDWILGGTKVGSVHCCISCCRWNFV
DPDKFIPERWLSAPAY*NDDRRAMQAFKSSSLHFS*SLRLKMRLVLARLICEFDLELA
PGSE*WEGALVFNVWGTKPFKI
CYP65AD1 Aspergillus oryzae
GenEMBL BAE55230.1
45% to 65V1, 43% to CYP65AF1
MFPCCLVPTISTSQPVEVSIAAIASWSYNVFFHPLSNYPGPRLAAATRLWYAWHCAKGSLPFAIHKLHLR
YGDVVRVAPDELSYIHPDGWNEIYGHRPGQSEIPKDPSFYSSALSSPEGIFRAPRDRHGYIRRQMSHGFS
EKSMREQEDTIRHYADLMISYLSTQANGPKENVVDFTRWYNYFTFDVMGQLVFGESFNCLQSSGFHPWVS
IIFDSIRYNVFVRCTQFWPWLSPVIRRFIPKSFQRRKIEQQALSREKANYRKTIHDGRNDLVANLLKPDS
GVTDLEYQSTVQTLIVAGSETTASLLCGVTFHLLNNPEKLEKAVKEVRSEFDSADKISFVSVNKLHYLLA
CLNEALRVYPPVADGFPRRTGSNVEVINGQPVPPNTAIRMTHWATYRSPRNFVRPNEYLPERWLGNAPGF
EKDHKNALQPFHVGPRNCIGRNLAYMEMRLLLALVLWNFDLELYPASKLWDKQRVYNLWEKPELKVKVLP
RKI
CYP65AD1 Aspergillus flavus
see fungal pages for seq
CYP65AD2 Aspergillus terreus
AAJN01000140.1
60% to CYP65AD1 Aspergillus flavus
see fungal pages for seq
CYP65AE1 Aspergillus oryzae
GenEMBL BAE60010.1
40% to CYP65AF1, 39% to 65S2
MEALPTYLESFWHSGGGTMGISILVMLSTFLALGTIFVYRIWLHPLSGFPGPKCCSVSSIPVAWAQLRGR
NHEFVSSLHRKYGSVVRISPSELSFISGAAWNDIYSRSKGRPALERDRTFFNDMLVDPETITMANEATHS
RIRRAMAPAFSPRALLEQEPIIQANIKLLMDKLEARAGSGGAPTDLRAWFNYTTFDLIGDLAFGESFGCL
ATSTCHEWVQFVLDHFYTSTLLHVVHRFHPFNRVLAALLPKSLIEKRKAHDSMTLTKVHRRLEVQGRRND
FTQHLLDAAEAGTLSSREVEKQASVLILAGSETTSVALTFAIYLVLTNKPVLDQLNDELHSTFKEEQEIN
LLSVNQLKYLHAVIQEALRFCPPISNGFPRQTPPQGATVDGMFIPGKTVVNINHWAAYRSPRNFTLPEQF
LPERWLGDPRFDEDAKDVFQPFSVGPRNCIGKKFAYDSMKLILAKFLWRFKPTLLDKSRSWLAHQPTFVS
FHQPPLLVDLEIKGSDAFPVRE
CYP65AF1 Aspergillus oryzae
GenEMBL BAE65144.1, AP007171.1
46% to 65T1 50% to 65S2
14 P450 genes and 2 pseudogenes on this contig
MLSFLPLPGPFSSPVGTVGFYLGLGVLL (0)
SILYLFAVIIYNVYFHPLAKFPGPKSYAATRIPYFQALLGGQIGQAIKDLHQK
YGEVVRIAPNELSFIDGEAWKAIYGTRPGHKQKPKDVRYYPPTAGGVPSIVISNDEDHSRFRRTLSHAFS
ETSLRVQEPLVNSYIDLLIQRLHEHCEAGNKPLDMVAWYNFTTFDIIGDLAFGEPFNCLQNSAYHKWVSM
IFSNIRYGTYGNLARRFPGSKFLLRLITPTRIANGRNWHIELTKEKVKDRLAKSNDRMDFYGHILKQKDT
ERAMTFDEMVTNGSTLIVAGSETTATLLSAVTFYLLKNERVLSKLQQEIRASFESEKDITVTGCNQLEYL
NAVLTEGLRIFPPTPTGLPRIVDADGDMIAGKWVPGGTIVSIPHLAAFHSASNFTEPESFIPERFLGDPR
FANDSKTVLQPFSFGPRNCIGRNLANAEMRLILARVLYNFDLELDERSENWSRQETYILWNKPGLYVRLR
PRVGI
CYP65AF1 Aspergillus flavus
98% to CYP65AF1 Aspergillus oryzae
see fungal pages for seq
CYP65AG1 Aspergillus oryzae
GenEMBL BAE60004.1
45% to CYP65AF1, 39% to 65U1, 47% to 655Z1
MSRRFPIQVAQSEIPPIAWGLWRMVYRLWLHPLSGYPGPRLAAVSNLPYFAWTCTGNLHLRLQELHKVYG
DVIRIRPNALTYRTPEAWTDIYGHRKPGTLPFSKDPEFFMPAQAGSSHMINANEKDHTRQKRLLNHAFSE
RSLRQQEHLIMGYIDLFIQRLRGQARMGAETVNMEEWLNFLTFDIIGDLAFGEPFGCLQNSEYHPWVATI
FKSIKTGAILRALNIYPILLGFIRRFLPKSLVQKRIAHYQMSKDRVTRRLQTETSRPDFISYILKYNDDR
GMSTPEIEMNAALLIQAGSETTATVLAACLYFLQKNAACHRRLVQDIRSAFTQETDINFLSAAQLPYMNG
VIEESLRLFPPAPGIGPRVVPKGGARICGRYVPGGVSVSVGHYSTFRSARNFTRPNEFLPQRWLDRDAES
EFASDQTMALQPFSYGPRACIGRNLAYAEMRTILAKILWHFDVQLDERSADWANSKSYIVWEKGPLWLKL
HPRNVPQETD
CYP65AG2 Aspergillus niger
JGI gene model e_gw1.3.1457.1|Aspni1
57% to CYP65AG1
see fungal pages for seq
CYP65AG3 Aspergillus terreus
64% to CYP65AG1
see fungal pages for seq
CYP65AH1 Gibberella moniliformis (also Fusarium verticillioides)
AF155773.4
fumonisin biosynthetic gene cluster,
FUM2
47% to 65L1, 45% to CYP65R1
MYQITAICDARWWLCLAFTCMAMLALFSFGVVMYNIFFHRASKF
PGPTIAGATSFRYHWAMSTGNVAPWLREQHARYGEVVRIAPDMISYVSPDAWKDIYAY
KPGEKEQNGIDWTIPSRDDDVPSMFSEPNDAEHNRVRRLFLPAFSDRALKQQEPLLSK
YSDQLVHLIRRGIDDNRDQEFDAVKLYNFTTFDIMGDLTFGEPLGLLKNSSYSEWVQN
LFRDIKTAGIFLFIFDFPPLPWLVKKFSPPSIQRAHEIHKQHTVDRVNRRLEKGLDRP
DIWNLVLSQPEGRGLTHPQMHANADIFMIAGTETTATLLSGLTYLLLKNPEKLQRLVE
EIRGSFGSIEELTVENLARLPYLSACLSEGLRCYPPVPIGPSRVTPKTGGQVLGERVP
GRVRLTIPQCAAYYSDLNFKDPYSFIPERWLPGTGYESDRKGILQPFLIGPRNCIGQN
LAYHEMRLILCKLLWHYDIELCPDKGNWLLDQKMYIFWEKRPLMVKFTKARK
CYP65AJ1 Alternaria solani
Alt1 BAD83680 48% to 65J1 Mg
PKS for alternapyrone is next to three P450s called alt1, 2, 3
Chem Biol. 2005 Dec;12(12):1301-9.
1 MPAASELERR TKRSKSRNKI SKPIANMLSV IAFSICISPI VYFLIRSIYY LVFHPLSDYP
61 GPKLWAISRI PWNYVNLQGD LAWRIRDMHL HYNSSVIRIA PDELSYTSST ALKKIDGTPP
121 PREFLKCLDG RGIAPAVVNR RRSIVTETPE RHTILRRALQ PAFSERALRD QEDFFRDHTD
181 RLIAQLRKPQ YGVTEQNILR WFALLSFDIM SDLAFGQPAG CLDLVDEPWL GVIGSRVKSI
241 VWYQFAVYYR IEWILKWIMP KAAMEARKRH QALTLQKVQR RIEEERSGKR EGKKRDFMSY
301 ILGNDKENLS NMDLFGMASA FIVAGSNTTT YTMTAFTFFV CRDSEVYAKV IAEVRDKFAS
361 DTDITMVAAG DLPYLKACIE ETMRLSPPTP SALPRWVLEG GEEIDGKWVP GGVTVGVHNL
421 AACHVPWNWH RPLEFIPERW LQTKEGEFTH DDRALHARFL MVDIMSLTCF LSSMAMNEMR
481 LALAKLFWNF DISLSRNSGN WWITQKSYLV WEKKPLMVTI KPRH
CYP65AK1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_9000016|Aspni1
42% to CYP65R1, 34% to fgenesh1_pg.C_scaffold_5000711
see fungal pages for seq
CYP65AL1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_5000711|Aspni1
42% to CYP65Z2, 43% to CYP65Z3
see fungal pages for seq
CYP65AM1 Aspergillus niger
JGI gene model estExt_Genewise1.C_31719|Aspni1
45% to CYP65AF1, top 28 hits are CYP65 or CYP60
see fungal pages for seq
CYP65AM2 Mycosphaerella graminicola
65% to CYP65AM1 A. niger
see fungal pages for seq
CYP65AM3 Aspergillus clavatus
92% t0 65AM1
see fungal pages for seq
CYP65AM4 Mycosphaerella fijiensis
62% to CYP65AM2 Mycosphaerella graminicola
JGI gene model estExt_fgenesh1_pm.C_10205
see fungal pages for seq
CYP65AN1 Aspergillus niger
JGI gene model gw1.16.109.1|Aspni1
36% to CYP65Z1 top 26 hits are to CYP65 or CYP60
see fungal pages for seq
CYP65AP1 Aspergillus niger
JGI gene model gw1.10.1058.1|Aspni1
40% to CYP65AF1, 60% to fgenesh1_pg.C_scaffold_1001144
Top 27 hits are CYP65 or CYP60 (CYP5118 also in this set, may need name
change = 41% to CYP65Z2)
see fungal pages for seq
CYP65AP2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_1001144|Aspni1
40% to CYP65Z2, 60% to gw1.10.1058.1
see fungal pages for seq
CYP65AP3 Histoplasma capsulatum G217B
ABBT01000035.1 Ajellomyces capsulatus G217B
68% TO CYP65AP1
see fungal pages for seq
CYP65AP4P Aspergillus terreus
some parts are 76% to CYP65AP1 Aspergillus niger
see fungal pages for seq
CYP65AQ1 Aspergillus niger
JGI gene model gw1.10.1062.1|Aspni1
37% to CYP65Z2 top 36 hits are CYP65
see fungal pages for seq
CYP65AR1 Aspergillus niger
JGI gene model gw1.11.201.1|Aspni1
36% to CYP65AH1, top 21 hits are CYP65
see fungal pages for seq
CYP65AS1 Mycosphaerella graminicola
39% to CYP65E1, all top hits except CYP5117A1 are CYP65 sequences.
This may mean that CYP5117 should be renamed.
N-term from JGI model estExt_Genewise1Plus.C_chr_11525|Mycgr3
see fungal pages for seq
CYP65AT1 Mycosphaerella graminicola
JGI gene model e_gw1.3.1373.1|Mycgr3
40% to 65L1, 41% TO 65Z2
see fungal pages for seq
CYP65AU1 Coccidioides immitis
47% to CYP65X1
see fungal pages for seq
CYP65AV1 Histoplasma capsulatum
39% to CYP65AZ2, 40% TO CYP65AF1
see fungal pages for seq
CYP65AW1 Fusarium oxysporum
44% to CYP65A1 Fusarium sporotrichioides
see fungal pages for seq
CYP65AW1 Fusarium verticillioides
90% to CYP65AW1 Fusarium oxysporum = ortholog
see fungal pages for seq
CYP65AX1 Fusarium oxysporum
42% to CYP65B1
see fungal pages for seq
CYP65AX1 Fusarium verticillioides
94% to CYP65AX1 Fusarium oxysporum
see fungal pages for seq
CYP65AY1 Aspergillus flavus
40% to CYP65S4 Fusarium verticillioides
Note: there is no ortholog of this gene in A. oryzae
see fungal pages for seq
CYP65AY2 Penicillium chrysogenum Wisconsin 54-1255
AM920421.1
61% to CYP65AY1
MQLLEWVVALTGLVWHTQGSFTPSLEQSTNLVQ
364847 WIISHLCLAIYNVFFHPLRNYPGPKLDAATGLVYVYHMVRGNSCKYLAGLHEKYGEVVRA 365026
365027 GPNEISYMTVSANKTIFGNKTTEKMSFEKNPAVYIQGEGTAQNILFASTGEHPRFKKLMS 365206
365207 PAFSEQAIKEQEPTIQQYTSIMIDALRNNRSGEACYPDANGIANIGAWCNFLIFDILSCL 365386
365387 SFGKPIGCLQMADYHEWANVIFGAMKHSHFLQCAHRLKPYHRLLEKLIPGDISGPYETHM 365566
365567 QNVRKNLRERETMENLARADFASFIPKGMSEDELVDNVNILATAGSETTATTLSSLFY 365740
365741 YLTHNPDSYQKLVDEVRSTFSSEEEITFNAVASLKYLKAVIQETFRIHPSVPVGLHRITP 365920
365921 KAGSYIDGKWVPG 365959
365982 QTWVSVALLAAYRSPRYWKQPEDFLPERWLEDPEFASDNRQIWAPFSIGPRKCIGIN (2) 366182
LAYLNMRLIVARLLWNFDFDPQPDNVDPHELKEYGVWQG 366356
QVPLNLKIRDARA* 366398
CYP65AZ1 Aspergillus oryzae
GenEMBL BAE63025.1
39% to 65S2, 41% to 65Z2
formerly CYP5118A1
see fungal pages for seq
CYP65BA1 Aspergillus terreus
43% to CYP65AF1
see fungal pages for seq
CYP65BB1 Mycosphaerella fijiensis
JGI gene model e_gw1.18.265.1 revised at N-term
46% to CYP65AF1 Aspergillus oryzae
45% to CYP563A2 Botrytis cinerea
44% to CYP65S2 Nectria haematococca
43% to CYP65Z2 Neosartorya fischeri
see fungal pages for seq
CYP65BC1 Metarhizium anisopliae var. acridum Ma102
CYP65BD1 Metarhizium anisopliae var. acridum Ma102
CYP65BD1 Metarhizium anisopliae var. anisopliae Ma23
CYP65BE1 Metarhizium anisopliae var. acridum Ma102
CYP65BF1 Metarhizium anisopliae var. acridum Ma102
CYP65BG1 Metarhizium anisopliae var. anisopliae Ma23
CYP65BH1 Metarhizium anisopliae var. acridum Ma102
CYP65BH1 Metarhizium anisopliae var. anisopliae Ma23
CYP65BJ1 Grosmannia clavigera
CYP65BJ2 Grosmannia clavigera
CYP65BJ3 Grosmannia clavigera
CYP65-un1 Magnaporthe grisea
MG09636.4 poor match 39% to MG02982.4
AACU01001669 cont2.1850 PSEUDOGENE
see fungal pages for seq
CYP65-un2 Aspergillus flavus
45% to CYP65L1
see fungal pages for seq
CYP65-un2 Aspergillus oryzae
45% to CYP65L1
100% to CYP65-un2 Aspergillus flavus
Supercontig 26: 405493-406148 (-) strand
see fungal pages for seq
CYP65-un3 Aspergillus terreus
36% to CYP65AQ1
one frameshift, possible CYP65 pseudogene
30/31 top hits are CYP65
see fungal pages for seq
CYP65-un4 Mycosphaerella fijiensis
JGI gene model e_gw1.3.1109.1
46% to CYP65-un2 Aspergillus flavus
see fungal pages for seq
CYP65-un5 Mycosphaerella fijiensis
JGI gene model e_gw1.8.672.1
45% to CYP65AS1 Mycosphaerella graminicola
see fungal pages for seq
66A Subfamily
CYP66A1 Agaricus bisporus (a mushroom)
GenEMBL Z82021 (932bp) AW444023.1 adds C-term
De Groot, P.W.J., Schaap, P.J., Van Griensven, L.J.L. and Visser, J.
Isolation of develpmentally regulated genes from the edible mushroom
Agaricus bisporus.
unpublished
Note: CYP66 is most similar to CYP64
WSYINSIVANSLWNSVKERMEAGTAKPCIATAMLEDLLDDDSAE
SKEEETVRRGACANGFLGGADTTVSLVTSFFMAMALYPDVQKKAQAELDQVLGGRLPE
FSDRPSLPYVNALLKESERWQPVFPLAIAHMSSNADEYDGYYIPKGTYVIGNAWSILH
DPEFYKDPLVFNPDRFLKDGEIDPSVRDPNVASFGFGRRICPGRFFPDASLYSTVTHV
LTVFDIKPNLDENGKEIGIKPDMTDGLLSIPM
CYP66B1 Agaricus bisporus (edible mushroom)
GenEMBL ABI271707
50% to CYP66A1
partial mRNA
QLKSVRTFIRNVMESPDEFSEWIHFYTSSSIMEIIYGMKAKPED
PYVDNAKKAIEGFNEAAVPGKFLVETFPVMKHIPSWFPGAGWKRQALFWRDVNREVRV
RPFNLVKDQVNEGTATRSVCRTLIGNLPDSTAPDRIVKENIAIDTCAVSFIGAAETSH
SAARVFFMAMLMNPEVQKKGQAELDKVLNGRLPEPNDGPNLPYISAMVKETLRWQLVL
PLAVPHVAIEADEYNGYYIPKGTIVFGNSWTFMHDPEVYKDPESYMPERFLKDGKLDS
SIRDPSTAVFGYGRRICPGRYFALNALYLMIAHTLAVFDIKPALDENDNEKEFKADVT
GGMISQPVPFQCMIVPRSKAAADLIQNSDLME
67A Subfamily
CYP67A1 Uromyces fabae (fungus)
GenEMBL U81793(1849bp)
Hahn,M. and Mendgen,K.
Characterization of in planta induced rust genes isolated from a
haustorium-specific
cDNA library.
unpublished (1997)
CYP67A2 Puccinia graminis f. sp. tritici
76% to CYP67A1 Uromyces fabae
see fungal pages for seq
CYP68A1 Gibberella fujikuroi (a rice pathogenic fungus producing plant
hormones(gibberellins))
GenEMBL Y15277
Malonek S, Bomke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P,
Tudzynski B. (2005) Distribution of gibberellin biosynthetic genes and
gibberellin production in the Gibberella fujikuroi species complex.
Phytochemistry. 2005 Jun;66(11):1296-1311.
Malonek S, Rojas MC, Hedden P, Gaskin P, Hopkins P, Tudzynski B. (2005)
Functional characterization of two cytochrome P450 monooxygenase genes,
P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium
proliferatum (Gibberella fujikuroi MP-D).
Appl Environ Microbiol. 71, 1462-1472.
called P450I or P450-1 GA14-synthase
CYP68A1 Gibberella proliferatum (teleomorph sexual form)
Fusarium proliferatum (anamorph asexual form)
GenEMBl AJ628021
Malonek S, Bomke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P,
Tudzynski B. (2005) Distribution of gibberellin biosynthetic genes and
gibberellin production in the Gibberella fujikuroi species complex.
Phytochemistry. 2005 Jun;66(11):1296-1311.
Malonek S, Rojas MC, Hedden P, Gaskin P, Hopkins P, Tudzynski B. (2005)
Functional characterization of two cytochrome P450 monooxygenase genes,
P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium
proliferatum (Gibberella fujikuroi MP-D).
Appl Environ Microbiol. 71, 1462-1472.
Ortholog to Gibberella fujikuroi 68A1
GA14-synthase
MTNHSSSYYYEFYKDHSHTFRRSMSENTLISSCLALATCAILLS
IQWLKPQPLIMVNGRKFGELSNVRAKRDFTFGARQLLEKGFKMSPDKPFRIMGDVGEL
HILPPKYAYEVRNNEKLSFTMAAFKWFYAHLPGFEGFREGTNESHIMKLVARHQLTHQ
LTLVTGAVSEECALVLKDVYTDSPEWHDITAKDANMKFMARITFRVFLGKEMCRNPQW
LRITSTYAVIAFRAVEELRLWPSWLRPVVQWFMPHCTQSRALVQEARDLINPLLERRR
EEKAEAERTGEKVTYNDAVEWLDDLAREKGVGYDPACAQLSLSVAALHSTTDFFTQVM
FDIAQNPELIEPLREEIISVLGKQGWSKNSLYNLKLMDSVLKESQRLKPIAIASMRRF
TTHNVELSDGVILPKNKLTLVSAHQHWDPEYYKDPLKFDGYRFFNMRREPGKESKAQL
VSATPDHMGFGYGLHACPGRFFASEEIKIALSHILLKYDFKPVEGSSMEPRKYGLNMN
ANPTAKLSVRRRKEEIAI
CYP68B1 Gibberella fujikuroi (a rice pathogenic fungus producing plant
hormones(gibberellins))
GenEMBL Y15278
Malonek S, Bomke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P,
Tudzynski B. (2005) Distribution of gibberellin biosynthetic genes and
gibberellin production in the Gibberella fujikuroi species complex.
Phytochemistry. 2005 Jun;66(11):1296-1311.
called P450II 38% identical to CYP68A1
CYP68C1 Fusarium sporotrichioides (fungi)
GenEMBL AY040587 (not released yet)
Andrew Peplow Isaac Meek
Clone name TRI1
Submitted to nomenclature committee July 25, 2001
Low 40% range with 68A1 and 68B1, 44% to 68D1
CYP68C2 Fusarium graminearum
FG00071.1 AACM01000004 FGcontig1.4_scaffold1
See fungal pages for sequence
CYP68D1 Neurospora crassa
GenEMBL AL355928.2
Neurospora crassa sequence contig 1.317 (supercontig 36)
lovA
sequence below not annotated in genbank entry
46% to 68C1
MANPSATPSSIPSWMERLDIKSITDPSATPFSYLVTAFLLAVVVYSLQGPRFPKNIKHLN
PKGPLEFSDTRPKKEFVYGSRQMLANWFKANPNKPCRVISDFGEAIVLPPRMANEIKNDD
RLSFTRWTYK (phase 0 intron)
AFHGHLPGFEGFGEASRESHIVQEVIMRDLTKYLN (phase 1 intron)
KVTEPLAQETSMAMEANLPKAANGEWSTINLRSKILPIVARISSRVFLGEELCRNEEWLK
VTQQYTIDGFGAAEDLRLWPAALRPIVHWFLPSCQRARADVRVARSILDPVLKKRRQEKA
ANGGKAEHDDAIEWFERTAKGKYYDPAVAQLVLSLVAIHTTSDLTCQVMTNLMQNPEFIA
PLREEMIQVLSEGGWKKTSLYNMKLLDSVIKESQRVKPTGVASMRRYAEKDVTLSDGTFI
PKGGFVAVSAHDMWNSEVYEQAEKWDGRRFLRMRETPGAGKENVAQLVSTAPEHLGFGHG
QHACPGRFFAANEIKIALVHLLLNYEWRLPEGSDPKIRTFGFSMGVDPSLKVEYKGRQPEIEL*
CYP68D1 Neurospora discreta
JGI gene model estExt_fgenesh2_pg.C_110241
92% to CYP68D1 N. crassa
See fungal pages for gene model
CYP68D2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.16.35.1
Necha1/scaffold_16:246007-247770
55% to 68D1, 48% to 68C2
See fungal pages for gene model
CYP68D3 Aspergillus niger
JGI gene model e_gw1.6.1239.1|Aspni1
60% to CYP68D1
See fungal pages for gene model
CYP68E1 Magnaporthe grisea
MG10527.4 with C-term extension = accidental fusion
AACU01001764 cont2.2024
See fungal pages for gene model
CYP68F1 Magnaporthe grisea
MG00300.4 36% to 68A1 35% to 68D1 AACU01001402 cont2.70
See fungal pages for gene model
CYP68frag Magnaporthe grisea
MG10029.4 AACU01001319 cont2.1919
62% to CYP68A1 C-TERM fragment RUNS OFF END
VACTPTHFGFGHGVHACPGRFFAANEVKIALAHILLKYDWKLA
EGSEKLEPVERGLNYVVNPNIKFLIRRRKEELDLESLEF*
CYP68G1 Magnaporthe grisea
MG03834.4 40% to 68B1 AACU01001031 cont2.748
See fungal pages for gene model
CYP68H1 Magnaporthe grisea
MG02294.4 41% to 68B1 39% to 68D1 AACU01000444 cont2.449
See fungal pages for gene model
CYP68H2 Magnaporthe grisea
MG11075.4 38% to 68B1 AACU01001898 cont2.2223
See fungal pages for gene model
CYP68H3 Magnaporthe grisea
MG00024.4 41% to CYP68B1 41% to 68D1 AACU01001352 cont2.7
See fungal pages for gene model
CYP68J1 Fusarium graminearum
FG02672.1 AACM01000132 FGcontig1.132_scaffold1
See fungal pages for gene model
CYP68J2 Fusarium graminearum
FG04717.1 AACM01000196 FGcontig1.196_scaffold3
See fungal pages for gene model
CYP68J3 Fusarium oxysporum
68% to CYP68J1
See fungal pages for sequence
CYP68J3 Fusarium verticillioides
95% to CYP68J3 Fusarium oxysporum = ortholog, 60% to CYP68J4
See fungal pages for sequence
CYP68J4 Fusarium oxysporum
70% to CYP68J2 Fusarium graminearum
See fungal pages for sequence
CYP68J4 Fusarium verticillioides
83% to CYP68J4 Fusarium oxysporum probable ortholog
See fungal pages for sequence
CYP68K1 Fusarium graminearum
FG11002.1 AACM01000457 FGcontig1.457_scaffold8
See fungal pages for gene model
CYP68L1 Aspergillus nidulans
AN8530.1 45% to 68A1 54 clan
See fungal pages for gene model
CYP68L2 Aspergillus oryzae
GenEMBL BAE66422.1
59% to 68L1, 47% TO CYP68Q1
MLGDLFESVLTNNSVTLLITVAVAAIALHLSSPKSNLPLVNDKKPWEFRFTKARKRFLANAHNLIKAGLA
KAPAFRIVTGNGKRVVLDAKYANELRSHDDLSFGLHIADNFHAHIRGFQPFKQGSNDDEIYQNAVRMKLT
QSLGNLTQPLVDETLVALQTYWTNDTNWHAIPLKSNIQKVVAQLSSRIFLGDQICRNPNWLRIAVDYTVD
AFKAAEELRLWPKAFRAIVALFLPSCRKIRAELQEAQDIIRPVLDARRKDKQAALSAGKEPERYNDAMQW
LEECAKGRSYEPAFGQLTFSVAAIHTTSDMLTQVLYDLCGRDALIQALREEVITVVQEEGWTKPTLYKLK
LMDSVLKESQRLKPISVVSMQRVATADLRLSDGTFIPKGTSLAVSSDRMWDSEIYPNPLEFDGYRFLKLR
ELPGHETSAQVVSPSPEHMGFGFGRHACSGRFFAINEVKIALCHILLKYEFKLADGSVPRATKFGFSFTS
DPTTKLMIRRRQEETVL
CYP68L2 Aspergillus flavus
97% to CYP68L2 Aspergillus oryzae
See fungal pages for sequence
CYP68L3 Histoplasma capsulatum G217B
ABBT01000111.1 Ajellomyces capsulatus G217B 382612-384420 (-) strand
57% to CYP68L2
See fungal pages for sequence
CYP68L4P Aspergillus clavatus
AAKD03000015.1 117585-116726 (-) strand mid region is 63% to 68L2
See fungal pages for sequence
CYP68L5P Aspergillus fumigatus Af293
XP_752004.1 also EAL89966.1
Internal fragment, needs revision
Pseudogene fragment mid region aa 183-260
62% to CYP68L3 Histoplasma capsulatum
74% to CYP65L5P Neosartorya fischeri
formerly CYP5088A1
KICRNPDWLRITVGYTVDTF &
LPAENLQLWPRLIRPVVAKF &
LPPCRKICWELKEATEIITPVLEERQ
CYP68L5P Neosartorya fischeri
62% to CYP68L3
Supercontig 569: 1883929-1885384 (+) strand
MAASRIATCMKDKMLTDISTQLFRLDP
ISLAGVLAISGLFFLLTLPSKA &
SIPMVNVKKLFQIRSSHIQKRYLDACKLSKTGSRK ()
APSFRVHSDNGIKTMLAPEYANEFHAHPALRFGRAITLEFHSD &
FLGD KICRNPDWLLITVDYTVDTFFAAEDLRLWPRLIRPIVANFLPSCRKIRRELKEA
PVLEERR DLEAARKANQPQKRYHDAIQLMEECAKGQHYPPAEAQMAFSIVAIHTTSDMLT
QVLLDLCANPEVIQPLREEIVAVNQEE*WKKTALYKLKLLDS
VLKESQRMKPVNI
ASMRRLALEDIKLSDGTLIPKGSSILVSSRKMWDPDAYPNPELFNPYRFLRLRETPGHET
SAQLVWPSPDLGFGYGKHACPGRFFTANEVKIALCHIILKYNFNLPDGYTPTVRKRGIS
LSADPSAKLVIRRRQEEIAL*
CYP68L6 Aspergillus terreus
63% to CYP68L3
See fungal pages for sequence
CYP68L7 Aspergillus terreus
54% to CYP68L6
See fungal pages for sequence
CYP68M1X Aspergillus nidulans
Name revised to CYP5073A1
CYP68N1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.41.77.1
Necha1/scaffold_41:90805-92550
48% to CYP68A1 Fusarium graminearum, 52% to CYP58D1 N. crassa
See fungal pages for sequence
CYP68N2P Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_36000012
Necha1/scaffold_36:51153-51671
48% to 68J2 C-term only, 64% to 68N1, pseudogene
See fungal pages for sequence
CYP68N3 Metarhizium anisopliae var. anisopliae Ma23
CYP68P1 Aspergillus fumigatus Af293
GenEMBL XP_756138.1 also EAL94100.1
41% to 68N1, 39% to 68A1
MDFLQRILGILSSEDVAPALFASSISVLFLILSYQVLYPPSKYSAFPTINGTRWLALSNRRILAEFVTDA
QGLMRNGLEKYDIFRIISSIGPMTILHPKYTDEIHNDRQLNFMAVLAKEMFPNYPGFDLFREGTDGSTVL
QDAVKFGSSRCLGKSTQLLSDETSTLLQKLWGDEPEWHEVTAKSSVHDIIAHLSALLFYGPELCSHKEWL
EVTDEYASVGFLAARQLRLWPPILRPIAQWFLPACRRLRYLASRTRGLIEPVIAARQKEKAICYSHGRQP
PVYDDAIEWTERAAKGRPYDAAMSPLLFSINALHTTTDLLTQVILDLSTQPDLIVALRQEILSVKPQQNG
WKNASLNQLLLMDSAIKESQRLKPTESILMRRYAMDDLTLADGNKIPKGTVLGIPIFGMRDPKIYVDPDM
YDGYRFQKMRDKPGFENKCQLVSTSPWHLGFGHGIHACPGRFLAAVQVKIILCYIVAKYDFKLAGGAPPK
VQSVGIELISDTEARLAVRRRQEMVIGLE
CYP68Q1 Aspergillus oryzae
GenEMBL BAE64916.1, AP007171.1
47% TO 68L2, 45% to 68L1, 48% to 68D1
14 P450 genes and 2 pseudogenes on this contig
MDHFNLAGPESNTSITSLEWLGIKNSFTGSHWAHITGLSELHPTGFLCLIATLIIGIVHLTRGPKPTVLP
VVNPPGTFELTANRVKKEWLVDARQIIRRGFEKFPGKPFNMIAADVGLTTVLPPEYASEIRNNPSLSFVA
FMAHLFFSELPGFEPTREGMFDNDIGITVVHKYLTVNLARITEPLSREATAALKDIFTDNSEWHDANLKA
INLALVARLSSRIFLGEELCRNEEWLKITVNYTVDVMKAAERLRRVPGPLRRIVHWFLPEAQKCRDEVKR
AGKVIRPVLEKRRREKATMESEGKEALQYNDAIEWFEQMAKSQGTSYDPEVVQLFLSTVAIHTTSDLLTV
VMADLARNPEIIEPLREEISSVLRDGGWKKTSLTDMKLLDSVLKESLRLKPIAVVSMRRVAMDHLKLSDG
TFLPKGTKMAVSSHRMWDPDVYENPEQWDGFRYVNLRETPGQDKHAQFVSTSERHLGFGHGKHACPGRFF
ASSELKVALCHILMKYDFELAPGTVVQHRYSGASYYADPAIRVMLRRRNVALPSWFER
CYP68Q2P Aspergillus clavatus
~73% to 68Q1 Aspergillus oryzae
pseudogene adjacent to CYP5117A2P on opposite strand
See fungal pages for sequence
CYP68R1 Aspergillus terreus
AF141924.1, XM_001209275.1
lovastatin biosynthesis gene cluster
gene="lovA"
function="involved in lovastatin production"
39% to 68D1 N. crassa
73% to CYP68R2 gene mlcC Penicillium citrinum ML-236B
(compactin) biosynthetic gene cluster
MTVDALTQPHHLLSLAWNDTQQHGSWFAPLVTTSAGLLCLLLYL
CSSGRRSDLPVFNPKTWWELTTMRAKRDFDANAPSWIESWFSQNDKPIRFIVDSGYCT
ILPSSMADEFRKMKELCMYKFLGTDFHSHLPGFDGFKEVTRDAHLITKVVMNQFQTQA
PKYVKPLANEASGIITDIFGDSNEWHTVPVYNQCLDLVTRTVTFIMVGSKLAHNEEWL
DIAKHHAVTMAIQARQLRLWPVILRPLVHWLEPQGAKLRAQVRRARQLLDPIIQERRA
ERDACRAKGIEPPRYVDSIQWFEDTAKGKWYDAAGAQLAMDFAGIYGTSDLLIGGLVD
IVRHPHLLEPLRDEIRTVIGQGGWTPASLYKLKLLDSCLKESQRVKPVECATMRSYAL
QDVTFSNGTFIPKGELVAVAADRMSNPEVWPEPAKYDPYRYMRLREDPAKAFSAQLEN
TNGDHIGFGWHPRACPGRFFASKEIKMMLAYLLIRYDWKVVPDEPLQYYRHSFSVRIH
PTTKLMMRRRDEDIRLPGSL
CYP68R2 Penicillium citrinum
BAC20565.1, AB072893
gene mlcC compactin biosynthetic gene cluster
join(AB072893.1 :15823..16167,
AB072893.1:16234..16405,AB072893.1:16469..17508)"
note="putative ML-236B biosynthetic gene"
73% to lovA CYP68R1
note: compactin is 6 desmethyl lovastatin
1 MLGQVLLTVE SYQWVSTPQA LVAVAVLLSL IAYRLRGRQS ELQVYNPKKW WELTTMRARQ
61 DFDTYGPSWI EAWFSKNDKP LRFIVDSGYC TILPSSMADE FRKIKDMCMY KFLADDFHSH
121 LPGFDGFKEI CQDAHLVNKV VLNQLQTQAP KYTKPLATLA DATIAKLFGK SEEWQTAPVY
181 SNGLDLVTRT VTLIMVGDKI CHNEEWLDIA KNHAVSVAVQ ARQLRVWPML LRPLAHWFQP
241 QGRKLRDQVR RARKIIDPEI QRRRAEKAAC VAKGVQPPQY VDTMQWFEDT ADGRWYDVAG
301 AQLAMDFAGI YASTDLFVGA LVDIARHPDL IQPLRQEIRT VIGEGGWTPA SLFKLKLLDS
361 CMKETQRIKP VECATMRSTA LRDITLSNGL FIPKGELAAV AADRMNNPDV WENPENYDPY
421 RFMRMREDPD KAFTAQLENT NGDHIGFGWN PRACPGRFFA SKEIKILLAH ILIQYDVKPV
481 PGDDDKYYRH AFSVRMHPTT KLMVRRRNED IPLPHDRC
CYP68R3 Monascus pilosus
DQ176595.1, ABA02241.1
monacolin K (lovastatin) biosynthetic gene cluster
possible GC boundary at exon 2/3 DNKggc
86% to lovA CYP68R1
41447 MTVPTDTVSRRLQSLAWSDIKQHAPWLPSSRTLVSGFLCLILLQILYSRGRKSDLRVYNP 41626
41627 KKWWELTTMRAKREFDANAPAWIEAWFSKNDQPLRFIVDSGYCTILPSSMADEFRKMKEL 41806
41807 CMYKFLGT (0) 41830
41908 DFHSHLPGFDGFKEVTRDAHLITKVVMNQFQTQAAKYTKPLADEASATIADIFGDNK (1) 42078
42144 EWHTAPVYNECLDLVTRTVTFIMVGDKLAHNEEWLDIAKHHAVTMAIQARQLRLWPVILR 42323
42324 PIVHWLEPQGAKLRAQVRRARQLLEPIIQERRAEKAKCLAQGIEPPRYVDSIQWFEDTAK 42503
42504 GQWYDAAGAQLAMDFAGIYGTSDLMIGGLVDIVRHPHLIEPLRNEIRTVIGEEGWTPASL 42683
42684 YKLKLLDSCLKESQRVKPVECATMRSYALQNVTFSNGTFVPKGELVAVAADRMSNPEVWP 42863
42864 EPKKYDPYRYMRLREDPDKAFSAQLENTNGNHIGFGWHPRACPGRFFASKEIKIMLAFLL 43043
43044 IRYDWKLVPNEPLQYYRHSFSVRIHPATKLMMRRRDEDL* 43163
CYP68S1 Aspergillus niger
JGI gene model e_gw1.4.292.1|Aspni1
51% to CYP68L2
See fungal pages for sequence
CYP68T1 Aspergillus niger
e_gw1.3.1460.1|Aspni1
51% to CYP68L2, 42% to e_gw1.4.292.1
See fungal pages for sequence
CYP68U1 Mycosphaerella graminicola
47% to CYP68N1 Nectria haematococca,
48% to CYP68D3 A. Niger
N-term from JGI model fgenesh1_pm.C_chr_10000062|Mycgr3
See fungal pages for sequence
CYP68V1 Histoplasma capsulatum G217B
50% to CYP68N1
See fungal pages for sequence
CYP68W1 Aspergillus clavatus
42% to 68D1
See fungal pages for sequence
CYP68X1 Neosartorya fischeri
47% to CYP68V1 Histoplasma capsulatum
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for sequence
CYP68Y1 Metarhizium anisopliae var. acridum Ma102
CYP68Y1 Metarhizium anisopliae var. anisopliae Ma23
CYP68Z1 Metarhizium anisopliae var. anisopliae Ma23
CYP68Z2 Metarhizium anisopliae var. acridum Ma102
CYP69A1 Gibberella fujikuroi (a rice pathogenic fungus producing plant
hormones(gibberellins))
GenEMBL Y15279
Malonek S, Bomke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P,
Tudzynski B. (2005) Distribution of gibberellin biosynthetic genes and
gibberellin production in the Gibberella fujikuroi species complex.
Phytochemistry. 2005 Jun;66(11):1296-1311.
called P450III a distant match to CYP54
CYP97E1 Skeletonema costatum (diatom)
GenEMBL AF459441
Yang,S., Wu,R.S.S., Mok,H.O.L., Zhang,Z.P. and Kong,R.Y.C.
Identification of a novel cytochrome P450 cDNA, CYP97E1, from the
marine diatom Skeletonema costatum (Bacillariophyceae)
J. Phycol. 39 (3), 555-560 (2003)
52% to 97B3, 51% to 97B2, 50% to 97B1
submitted to nomenclature committee Jan 28, 2001
this is the first full length sequence from a diatom
See stramenopile/diatom pages for sequence and a tree
CYP97E2 Thalassiosira pseudonana (diatom)
No accession
From JGI genome project
See stramenopile pages for sequence and a tree
CYP97E3 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
EST LQ0AAB42YI07FM1.SCF (C-term)
59% to CYP97E1 and CYP97E2 876 amino acids is very long for a P450
Ectocarpus sctg_63 344994-350246
CYP97E4 Phaeodactylum tricornutum (diatom)
estExt_Genewise1.C_chr_50056|Phatr2 (at JGI)
69% to 97E2 and 97E1
this gene model was automatically generated at JGI
I have not checked it, it may have some errors
MRSSDYSRAPRWESFVVLAWATASAVLVGNVFQQALPQPVQAFGPALVPHLSRRCDLIQRRVSSDLEDVDVDVDNDAILG
SNNIPRRLRIQGRGIPTRKDPIQPLDSMTYESDLIKTWEQDPSRQKGFDWEIEKLRRYFAGLRMRDDGVWVRQPSFFDFL
VSKSRSDPGNAPRPVGLVDVVKLVLTNSLTSVGLGPALGMAAVPNAVIQKYEGSFFSFIKGVLGGDLQTLAGGPLFLLLN
KYFEVYGPIFNLSFGPKSFLVVSDPVMARHVLRETSPDQYCKGMLAEILDPIMGKGLIPADPATWKVRRRAIVPSFHKRW
LNRMITLFAERAEILADDLQPKSAKGQVVDMEERFCSVTLDIIGKAVFNYDFGSVTDESPIIKAVYRVLREAEHRSSSFI
PYWNLPYADQWMGGQVEFRKDMTMLDDILADLINKAVSTRREASIEELEKRENEDDPSLLRFLVGMRGEDLSSMVLRDDL
MTMLIAGHETTAAMLTWTLFELSRGDPGLLKEVQAEVRTVLKGKERPDYDDIVAMKKLRYSLIEALRLYPEPPLLIRRAR
TEDNLPAGSSDLKSGVKVLRGTDMFISTWNLHRSPDLWENPEVFDPTRWDRPFNNAGIPGWSGYNPDKVSGLYPSENAAD
FAFLPFGGGQRKCVGDQFAMMEATVTMALMIKKYDFDFAIPAEDVGMKTGATIHTMNGLMMRARQVNENEPVQSAEGYWE
MQHLKRGLNANGRPYTTEEEAVWQTSERLSHKKEEEKPNGEGGCPMHKM*
CYP97F1 Thalassiosira pseudonana (diatom)
No accession
From JGI genome project
See stramenopile pages for sequence and a tree
CYP97F2 Euglena gracilis
GenEMBL EC678021.1 EST
60% to 97F1 of Thalassiosira pseudonana (diatom)
51% to CYP97B2 Glycine max, 50% to 97B3 Arabidopsis
52% to Pinus taeda CYP97B9, 50% to 97B4, 49% to 97B3
only 40% to 97A3 and 39% to 97C1 Arab.
This is the CYP97B ortholog
If euglena only has one CYP97, then CYP97B
May be the oldest CYP97 subfamily
IASALKNRDPADIADLEARDYDEMDNPSLLRILVDMRGEETTNQQLRDDLITLLIAGHET
TASALTWAIFELVQQPELLQRVQREVDEVLGDRLPTMDDIRGLLLCRLCIAESLRMYPEP
PLLIRRVLDDLTLPKGATAKFEATLKRATDIFLAIYNIHHDGRFWPNPDFYDPERFLRPY
KNPEIPEWKGYDPEGWKGRLYPDEVSSDYAFMPFGAGPRRCLGDVFATLEGTVALAMVLR
RFDFTFAAPTAQPD
CYP97F3 Phaeodactylum tricornutum (diatom)
e_gw1.27.30.1|Phatr2 (at JGI)
75% to CYP97F1
this gene model was automatically generated at JGI
I have not checked it, it may have some errors
MQVGKSGEEISFGDSANVLRTNIEQIYGGFPSLDGCPLAEGELADIGDGTMFIGLQNYYRNYGSPYKLCFGPKSFLVISD
PVQAKHILKDANTNYDKGVLAEILEPIMGKGLIPADPETWSIRRRQIVPAFHKAWLEHIVGLFGYCNQPLIDTLNKRVDG
DGKVEMESLFCSVALDIIGLSVFNYEFGSVTQESPVIKAVYSALVEAEHRSMTPAPYWNLPLANQLVPRLRKFNSDLKLL
NDVLDDLITRAKQTRTVEDIEELENRNYNEVQDPSLLRFLVDMRGADIDNKQLRDDLMTMLIAGHETTAAVLTWALFELT
KNPEIMKELQDEIDEVVGDRMPNYEDIKKMKFLRLVVAETLRMYPEPPLLIRRCRTPDELPQGAGREAKVIRGMDIFMAV
YNIHRDERFWPSPDTFDPLRFTRSHSNPDVPGWAGFDPKKWEGKLYPNEVASDFAFLPFGGGARKCVGDEFAILEATVTL
AMVLRRFEFSFDESKFEGKDDILSSAQGLNHPVGMRTGATIHTRNGLHLVVEKRGVPK*
CYP97F4 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAA4YK08FM1.SCF, LQ0AAB23YL07FM1.SCF
LQ0AAB3YI17FM1.SCF, LQ0AAB85YI22FM1.SCF
60% to CYP97F1 diatom, 62% to 97F3 Phaeodactylum
Ectocarpus sctg_63 359933-352442
Note: two digit names for lower eukaryotes end here and continue as three digit
names at
CYP501. Animal P450 families cover CYP1-49 and CYP301-499 are reserved for new
animal P450 families.
Cyp301a1 Drosophila melanogaster
GenEMBL AC017275 comp(35594-38192) also AC007356
possible mitochondrial P450 fits in the mitochondrial clan.
Cyp301a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP301A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2l3
CYP301A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.423b
66% to 301A1 Drosophila melanogaster.
CYP301A1 Linepithema humile (argentine ant)
No accession number
CYP301A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
86% to CYP301A1 Linepithema humile
CYP301A1 Solenopsis invicta (fire ant)
See Solenopsis page
89% to CYP301A1 Linepithema humile
CYP301A1 Pogonomyrmex barbatus (seed-harvester ant)
No accession number
Reed Johnson
Submitted to nomenclature committee June 3, 2010
61% to CYP301A1 Apis mellifera
CYP301A2 Drosophila arizonae
no accession number
from Tina Yee and Phil Danielson
submitted to nomenclature committee 6/29/99
84% identical to Cyp301a1
clone name DU36az
CYP301A1 Bombyx mori (silkworm)
BAAB01030444.1 BP117781 BAAB01134599.1 BAAB01155686.1 BAAB01102862.1
BAAB01093671.1 BAAB01132355.1 BAAB01006099.1
65% to Drosophila 301A1, 64% to Apis 301A1
CYP49 and CYP301 are nearly subfamilies of a single family
See silkworm page for sequence
CYP301A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
77% to CYP301A1 Helicoverpa armigera
91% to CYP301A1 Bombyx mori
CYP301A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_268 51% to CYP301A1, probable ortholog
CYP301A1 Plutella xylostella
Gene number CCG011722.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
90% to CYP301A1 Heliconius melpomene
CYP301A1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
89% to CYP301A1 Bombyx mori
CYP301A1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP301A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_974014
75% to 301A1 bee, 66% to CYP301A1 Drosophila
MVATSKFPQAAKIVKNITRSRSQTVTPAFCPHLENLNEAKPYSEIPGPKPIPILGNTWRLLPIIGQYDVS
DVAKLSELFYKEYGKIVKLSGLVGRPDLLFIYDANEIEKIYRQEGPTPFRPSMPCLVRYKSVVRKDFFGD
VGGVVGVHGEPWRRFRSTVQKPILQVQTVKKYIEPIENVTNYFIQRMMEMQNDDQEMPSDFDNEIHKWAL
ECIGRVSLDARLGCLDPNLPPDSEPQKIIEAAKYALRNVAILELKFPFWRYFPTSLWTRYVQNMDYFVEI
CMKHIDAAMERLKSKTVLDEKDLSLVERILANEPDPKTAYILALDLILVGIDTISMAVCSILYQLATRPE
QQEKMYQELKRVMPDPNTPLNTKLLDQMDFLKAFVKEVLRVYSTVIGNGRTLQQDTIIHGYRIPKGVQVV
FPTLITGSMEEFVSQSNEFIPERWMKKSSSDYKIHPFASLPYGYGARMCLGRRFADLEIQVLLAKLIRSY
KLEYHHEPLEYKVTFMYAPDGPLRFKVIKREE
CYP301A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 12
75% to CYP301A1 Tribolium castaneum
C-helix to PERF
CYP301A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
77% to CYP301A1 Tribolium castaneum
CYP301A1 Aedes aegypti (yellow fever mosquito)
CYP301A1 Culex pipiens
CYP301A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph301-2, 73% to 301A1 Tribolium
Pediculus genome site
CYP301A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
67% to CYP301A1 Tribolium castaneum, incomplete
CYP301A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP301A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig19832 231aa
67% TO CYP301A1 aphid, in the mito clan
CYP301A1 Acyrthosiphon pisum (pea aphid)
LOC100164600
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
mito clan
MKNIRQFQIHSIRWRSTATQHAHSPHVSAGSPEALEVTNDLITAKHYSQVPGPTPWPIIGNTWRMLPIIGPYQISDLANVSYILYKQYGKIAKLGNLVGRPDLLFVYDADEIEKVYRQEGDTPFRPSMPCLVKYKSQVRGQFFGRLPGVVGVHGEAWREFRTKVQKPVLQPQTVKKYIQPIEEVSDYFIKRMQEMKNENSEMPADFDNEIHKWALECIGRVALDARLGCLNPDLPKNSEPQKIIDAAKYALRNVALLELKYPFWRYLPSTLWKKYVSNMDYFIEICMKYIDDAMLRLKNKSQSVNESELSLVERILANEPDPKTAYILALDLILVGIDTISMAVCSMLYQIATRPEEQEKIHQEILKILPNKDDKLDASKLEKMVYLKAFIKEVLRMYSTVIGNGRTLQKDMVICGYRIPKGIQLVFPTIVTGNMEEYVTDCKQFKPERWLKQSTDYIHPFASLPYGHGPRMCLGRRFADLEMQVFLAKLIRSHKLEYLHKPLEYKVTFMYAPDGELKFKMTERPTS.
CYP301A1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
CYP301A1 Trialeurodes vaporariourum (whitefly)
CYP301B1 Tribolium castaneum (red flour beetle)
GenEMBL XP_974040
43% to 49A1 Drosophila, mito clan
60% to 301B1 bee, 48% to 301A1 bee
MKLLRAAKRVISSSSQQQLGVISAIEENHCKEWADAVPYEEVPGPKPLPFLGNTWRFIPFIGDFQIEHID
KVSKKLYEKYGKIVKMQGLLGRPDMLFLFDPDEIEKVFRQEDTLPYRPSMPSLNYYKHVHRKEFFGDNCG
VIAVHGDRWQNFRTKVNQIMLQPRVTRMYVKSIETTSQELVDRIEVIKNKKSEVPDDFLNELHKWSLESI
AKIALDVRLGCLDPNAHPDTQTLINAINTFFMNVPILELKIPFWKIWNTPTFKEYLHALDTIREITLKHV
DIALHKLSQDDCEELSVLQRVLKMENDAKTASNLALDMFLVGVDTTSNAVASILYQLSLHQEKQAKLYEE
IASLLPCKSTQISHEKLDQMHYLKACIKETMRMYPVVIGNGRCTTRDRVIGGYQIPKGVQVIFQHCVISN
LEEYFPRSGEFLPERWLKNSELFRNHHPFASLPFGFGKRMCLGRRFADLEIQTVIAKVVRNFKIEYHHDK
LDYHIHPMYTPYGPLRLTFIRRQ
CYP301B1 Acyrthosiphon pisum (pea aphid)
LOC100161793
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
mito clan
name corrected, formerly CYP49A1
MSVLARRLRNLRITVDHANKSTEVFTSVSQGDVDFVKDYSELPGPKSLPLLGNNWRFMSYIGDYKVTEIDKLSLRLWKEYGDIVKIEKLLGRPDMVFLYDADEIEKVFRNEELMPHRPSMPSLNYYKHVLRKDFFGDLAGVIAVIKKIKNKDQEVPDDFLNEIHKWSLESIAKVALDQKLGCLEDEHAVDSDTQNLIDAINTFFANVPELELKIPFWKLFSTPTWRKYINALDTITNVTSKHINRSMDRLLSQKSFCPDSQSSLLQRVLSLDPSNPKLAQILSLDMFIVGIDTTSAALASILYQLSRHPDKQKKLREEIRTVLPNADSKLTSSKLEQLQYLKACIKETLRMYPVVIGNGRCMTKETIISGYKIPKGVQVVFQHYAISNSSKYFSQPDQFLPERWLKGSGYKHHPFASLPFGYGKRMCLGRRFADLELQTVVSKIFQNFEVKYEYGDLEYTVHPIYMPDGPLKFKMIED*
CYP301B1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
65% to CYP301B1 Acyrthosiphon pisum, C-term only
name changed, formerly CYP49A1
CYP301B1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
60% to CYP301B1 Tribolium castaneum
CYP301B1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 33
68% to CYP301B1 Tribolium castaneum
mid region to PERF
CYP301B1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
63% to CYP301B1 Tribolium castaneum
CYP301B1 Bombyx mori (silkworm)
BAAB01133495.1 BAAB01150577.1 BAAB01091102.1 BAAB01198981.1
BAAB01133297.1 BAAB01093561.1
44% to CYP301A1
CYP49 and CYP301 are nearly subfamilies of a single family
Note: name changed based on Rene Feyereisens analysis
Formerly CYP49A1
See silkworm page for sequence
CYP301B1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
73% to CYP301B1 Bombyx mori
CYP301B1 Plutella xylostella
Gene number CCG011724.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
74% to CYP301B1 Bombyx mori formerly CYP49A1
CYP301B1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph301-1, 61% to 301B1 Tribolium, 58% to 301B1 Apis,
insert between PERF and Heme not in Tribolium
Pediculus genome site
CYP301B1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP301B1 Linepithema humile (argentine ant)
No accession number
CYP301B1 Solenopsis invicta (fire ant)
See Solenopsis page
70% to CYP301B1 Linepithema humile
CYP301B1 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf37 and sf30 two pieces probably from the same gene
63% and 74% to CYP301B1 Tribolium and Apis
CYP301B1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
64% to CYP301B1 Apis mellifera, incomplete
CYP301C1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph12, 39% to Tribolium 301A1, 39% to 301A1 Pediculus
(including Ns at N-term) and 39% to 301B1 Pediculus
39% to CYP12H1 Tribolium
Pediculus genome site
CYP302A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2l2
Note: in Drosophila Cyp302a1 is the disembodied gene (dib),
a C22 hydroxylase in the ecdysteroid biosynthetic pathway from cholesterol
Cyp302a1 Drosophila melanogaster
GenEMBL AC015396 31954-33705
Michael B. O'Connor
Submitted to nomenclature committee 11/17/99
30% to Cyp12b1 other best matches are 12 family members
the fly gene is called disembodied Dib
see <A HREF="http://flybase.bio.indiana.edu:82/.bin/fbidq.html?FBrf0101392">abstract</A>
Cyp302a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Gene name disembodied dib
CYP302A1 Bactrocera dorsalis (oriental fruit fly)
JQ027284
Lin Cong
Submitted to nomenclature committee 12/5/2011
64% to CYP302A1 D. melanogaster
CYP302A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2216
First 3 exons
45% to 302A1 Drosophila melanogaster.
disembodied ortholog
CYP302A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2216
Last 4 exons
51% to 302A1 Drosophila melanogaster.
disembodied ortholog
it is highly probable that these to partial sequences are
from the same gene (missing about 68 amino acids)
CYP302A1 Linepithema humile (argentine ant)
No accession number
CYP302A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
79% to CYP302A1 Linepithema humile
CYP302A1 Solenopsis invicta (fire ant)
See Solenopsis page
81% to CYP302A1 Linepithema humile
CYP302A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
78% to CYP302A1 Linepithema humile
Cyp302a1 Bombyx mori (silkworm)
BAAB01119552.1 BAAB01040509.1 BAAB01022270.1 CK534186
BAAB01132138.1
46% to 302A1 Anoph. Probable ortholog
See silkworm page for sequence
Cyp302a1 Bombyx mori (silkworm)
GenEMBL AB198340
Niwa, R, Sakudoh, T, Namiki, T. Saida, K, Fujimoto, Y, Kataoka, H.
The ecdysteroidogenic P450 Cyp302a1/disembodied from the silkworm
Bombyx mori, is transcriptionally regulated by prothoracicotropic
hormone. Insect Molecular Biology 2005 in press
CYP302A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
59% to CYP302A1 Manduca sexta
CYP301B1 Plutella xylostella
Gene number CCG011849.1, CCG004291.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
62% to CYP302A1 Bombyx mori
CYP302A1 Manduca sexta (tobacco hornworm)
GenEMBL DQ357067
Rewitz,K.F., Rybczynski,R., Warren,J.T. and Gilbert,L.I.
Identification, characterization and developmental expression of
Halloween genes encoding P450 enzymes mediating ecdysone
biosynthesis in the tobacco hornworm, Manduca sexta
Insect Biochem. Mol. Biol. 36 (3), 188-199 (2006)
MYRLLNNYKCVPCRKFIQRNYTMEVSHNIIQKEPQKESLLHLND
IPGPKCYPVIGTLHKYLPFIGDYDAEALDKIAWLNYRRYGCLVREVPGVNVIHVYDPD
DIEAVFRQDDRFPARRSHLAMYHYRKNKPQVYNTGGILSTNGPEWWRLRSTFQKNFTS
PQSVKAHVECTDDIAKEFVQWVHNRKFRCNEDFLIYLNRLNLEIIGAVAFNERFDSFS
PQEQHSKSRSSKIIQAAFGSNSGVMKLDKGFLWKFFKTPLYRKLAQSQEYLEKVSTEI
LMKKMKFFESNESDNDKSLLSSFLQQPNIDQKDIIGMMVDILMAAIDTTSYTTSFALY
HIARNPECQEKIFTEVETLLPEKDSSITPNVISKAVYTRSSIKESLRLNPVSVGIGRL
LQKDITLKGYFIPKDTVIVTQNMVSCRLPQYVREPLLFKPERWLRGSSEYENIHPFLS
LPFGFGPRSCIARRLAEQNMCIILIRLIRDFQIQWKGRELGIRTLLINKPDQPVTLSF
VPRLPRRL
CYP302A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_264 49% to CYP302A1, probable ortholog
CYP302A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_974252
47% to 302a1 Drosophila, 49% to 302A1 bee, 49% to 302A1 Anopheles
disembodied ortholog
MCLFSKKSVHYLLTIRTRNYYYRGRFLTTAVDPPKSFKEIPGPLSLPLVGTLYLYFPFIGRYQFDRLHKN
ALKNFQLYGPIIREEIVPGEHIVWLGDPDDIAKMFHTEGTYPYRKSHLTLEKYRLDRPHIYNSGGLLPTN
GPEWSRIRKVFQKGLSGPTEALSFIKGSDDVISEWLDTRFKKIHKETSNMDFLQELSRLFLELIGVAAFD
IRFQSFHDDELDPCSKSTKLLESAFVTNSTILKTDNGPQLWRKFETPAYRRLRKAQELMESVAIDLVALK
LSTFKEKTSNPPTLLERYLASASLDFKDIIGVVCDFLLAGMDTTTYSSSFLLYHLATNPSTQDALYEEAC
RLLPNPAAPLTTEKYKQAEYAKCAVKESLRLRPISIGVGRQLTTDVVFSGYKVPSGTVVVTLNQVLSRME
KYFPEPDSFKPERWMKNDPSYVQTHPYLVIPFGHGQRSCIARRFAEQNMVILILKLARKYKLRWNGSEID
SKSLLINKPDGPILLSFEPR
CYP302A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010, revised Nov. 22
mito clan
Clone name seq 18
59% to CYP302A1 Tribolium castaneum
complete
CYP302A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
65% to CYP302A1 Leptinotarsa decemlineata
CYP302A1v1 Aedes aegypti (yellow fever mosquito)
CYP302A1v2 Aedes aegypti (yellow fever mosquito)
CYP302A1 Culex pipiens
CYP302A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph302, 52% to 302A1 Tribolium, 54% to 302A1 Apis
ortholog to dib disembodied
Pediculus genome site
CYP302A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP302A1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Lce0063I12
68% identical to D. pseudoobscura CYP302a1 ortholog
only 183 aa
CYP302A1 Acyrthosiphon pisum (pea aphid)
LOC100165806
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
dib 22-hydroxylase
mito clan
MPSAKCFLGCTNVRYGARIVSILDFKSTLFQILRFSSTETTAVKEFNEIPGPTSLPLVGTLYQYLPVFGKYKFDRLHHNGLAKLRQYGPVVREDIVPGVSIVWIFKPEDIETLYRKEGRYPERRSHLALQKYRLSKPDVYNTGGLLPTNGSDWWRLRKAFQKHLSKVQCIKRYVDSTNTVVGEFIDRRIKRAELRDDFGPELSRLFLELTYYVAFDERLQRFKDEEWDSDSECSKLIKAAHDINSAIMKTDNGPQLWRKFDTPMYKSIQKGHEQIEKIALRVVNEKLISIKTTDSKTSLLGEYLSSDDTDFKDVIGMTVDTLLAGIDTATYSCCFGLYHLSSNPDVREKMFDESRALLPDNHTPVTDRVLERAVYAKAVVKEMFRMNPISVGVGRILPEECVFSGYRVPAGTVVVTQNQVSCRLEEYFRRPNEFLPERWIKGSAEYEPVSPYLVLPFGHGPRTCIARRLSEQFLQVVLIKIVRNFEMTWTGPKLDSESLLINKPDGPISIIFKTRD*
CYP302A1 Trialeurodes vaporariourum (whitefly)
CYP302A1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
40% to CYP302A1 Acyrthosiphon pisum (probable ortholog)
CYP302A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
40% to CYP302A1 Acyrthosiphon pisum, incomplete, 500 aa
missing the N-term
CYP302A1a Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
N-term part 95% to CYP302A1 Laodelphax striatellus
CYP302A1b Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
C-term part 86% to CYP302A1 Laodelphax striatellus
CYP302A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP302A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP302A1 Daphnia pulex (water flea)
Cyp303a1 Drosophila melanogaster
GenEMBL AC017306 12933-14444 no introns
Cyp303a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP303A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3r4
CYP303A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.2253
43% to 303A1 Drosophila melanogaster. Note this sequence is
named in the same subfamily as other CYP303As since
there seems to be only one orthologous sequence per
species and it does not make sense to name orthologs with
different subfamily names.
CYP303A1 Linepithema humile (argentine ant)
No accession number
CYP303A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
77% to CYP303A1 Linepithema humile
CYP303A1 Solenopsis invicta (fire ant)
See Solenopsis page
83% to CYP303A1 Pogonomyrmex barbatus
CYP303A1 Bombyx mori (silkworm)
BAAB01045446.1 BAAB01180906.1
BP126135 BAAB01031702.1
45% to 303A1 Probable ortholog
See silkworm page for sequence
CYP303A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
77% to CYP303A1 Bombyx mori
CYP303A1 Plutella xylostella
Gene number CCG015922.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
74% to CYP303A1 Bombyx mori
CYP303A1 Chilo suppressalis (striped rice stem borer)
No accession number
Jifeng Shi
Submitted to nomenclature committee May 1, 2012
77% to CYP303A1 Bombyx mori
CYP303A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966541
42% to 303A1 Dm, 47% to 303A1 Anopheles, 51% to 303A1 Aedes
MLLAIGFFVIILGLLAYLDTKKPKNYPPGPSWLPIIGSAHTIAEWRKKAGYLYKATAEM
AEKYGPVIGLRVGKDLIVVxxxxxxxx
EFLASDDLAGRPTGAFFDMRTWGERR (1)
GVLLTDSDFWQEQRRFILRQLREFGFG
RKNMSSMIEEETAIMVESYQKMLAGKKSVTLNMESAFNIHILNTLWMMMAGIRYSPEDKNLKSLQDILGR
LFSTVDMVGAPFSQFPILRFIAPEISGYKLYLETHLQIWEFLYDELKRHKETWDENNLRDFMDVYLKMLN
SPERKESFCEKQLLAICLDMFMAGSETTSKSLGFCFLNLIMYPDVQKKAQQEIDAVVGRNRLPSLEDRPQ
MPYMECVVLEALRMFSGRAFTVPHRAFKDTHLNGYIIPKDAMVIANMHGTLMGPESGVEDPEIFKPERYL
KDGKITLADTYLPFGFGKHRCLGETLAKANVFLFTASLLQHFNFSIVPGSPPTTECIDGVTPGPLPFKAL
VTPRE
CYP303A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
52% to CYP303A1 Tribolium castaneum
CYP303A1 Aedes aegypti (yellow fever mosquito)
CYP303A1 Culex pipiens
CYP303A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph303, 52% to 303A1 Aedes
Pediculus genome site
CYP303A1 Locusta migratoria manilensis
No accession number
Xiaoyu Ren
Submitted to nomenclature committee May 15, 2013
69% to CYP303A1 Acyrthosiphon pisum (pea aphid)
CYP303A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP303A1 Acyrthosiphon pisum (pea aphid)
LOC100162206
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
nompH (not a Halloween gene)
CYP2 clan
MWILVLVLFSVVVALLSYLDMRKPKNYPPGPKWLPILGSALTVNSLRKQTGYLYRATICLAESYGPIVGLKVGKDRQVVCCGYNAIKEMLTKEEFDGRPQGPFYETRTWGTRRGLLLTDEEFWVEQRRFVLRHLREFGFGKRTMAELVQDEAVQLVEDFKEKIAMSKNGNGEIFEMRDAFSVGVLNTLWSMMASKRYNADDIELKNLQALLTELFANIDMVGALFSQFPVLRFIAPEASGYKSFVNIHQQVWKFLKAELDDHKETFIINQPRDLMDVYLQMLHSEDKKESYSESQLLAICMDMFMAGSETTSKSLGFGFLYLLLNPEVQKKAQEEIDRVVGRDRLPTLNDRPNMPYLEALVLESVRVFMGRTFSIPHRALKDTTLQGYHIPKDTMVIANFAALLNDDDVWDHPDRFWPERFIGCDGKLIVPDEYLPFGYGKHRCMGQTLARSNIFLFSACLLQNFDFSVPDGQAPPSTLGVDGVTPSPGEFNAYVSLRPR
CYP303A1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
Two pieces 84-87% to CYP303A1 Acyrthosiphon pisum
CYP303A1 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf59
69% to CYP303A1 aphid
CYP303A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
Complete, 63% to CYP303A1 Acyrthosiphon pisum
CYP303A2 Linepithema humile (argentine ant)
No accession number
Cyp304a1 Drosophila melanogaster
GenEMBL AC008359 comp(80887-82836) also AC014292 AC009393
Cyp304a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP304B1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPg2r1
CYP304B2 Aedes aegypti (yellow fever mosquito)
CYP304B3 Aedes aegypti (yellow fever mosquito)
CYP304B4 Culex pipiens
CYP304B5 Culex pipiens
CYP304B6 Culex pipiens
CYP304B7 Culex pipiens
CYP304C1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPg2r2
CYP304C1 Aedes aegypti (yellow fever mosquito)
CYP304C1 Culex pipiens
CYP304E1 Tribolium castaneum (red flour beetle)
GenEMBL XP_973180
37% to 304a1 Dm, 40% to 304B3 Aedes, 38% to 304B1 Anopheles
AAJJ01000062.1, DT790944.1 DN650948.1 ESTs
MLGFLTLLVTFVTLLVFLFYKFSKERPENFPPGPPSLPIWGSYWFLLKENYNLLHLSFETLGKRYKTDIL
GFFLGNAPTVVTLSYELTKEMLSRDEFMGRNDTIIVQTRSRGSPKGIFFTDGPVWKQQRRFALRHMRDYG
FGRRSENMENLAHQETNYLIDFLTKEPSQGDLDVCKKKGLVLVPDFMYGSLINTVMLVLTSRHFEHQEVR
KYAKAAFRFMKSEDSTGGAITITPWLRYIAPTFFGFTSAVDDNDMLIDFMK (0)
GLIEEHVETFSDDHHRDFI
DDYISESIKQGIEID (1)
23621 YLQLALITLDFMFPSPVGVGHTLSFYFAHLINNPEIQTKIQEEIDQVVGRSRLPS
LDDRKDLPYFEASIRENLRLMPVTPLGVTRRCVKDTMLGGHFIPKDSFVLANLWTAHRDPRIWDDPEEFR
PERFLDSDGKLLRKDYTIGFGAGKRLCAGETYARNTMFLIMSGLLQNFTFKSPYNRPIDLKDVLPGVTLS
LKETWISAVPR
CYP304F1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_236 42% to CYP304B2 or B3, 39% to CYP304B1,
37% to CYP304C1, 41% to CYP304E1 Tribolium, 40% to CYP304A1
HAH003134 100% to Contig_236 except a short internal seq
Contig_226 1 diff to Contig_236, contig 226 and 236 agree in
Region where HAH003134 is different (frameshift?)
CYP304F1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
92% to CYP304F1 Helicoverpa armigera
CYP304F2 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_c481
63% to CYP304F1 Helicoverpa armigera (cotton bollworm)
CYP304F3 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP304F4 Spodoptera litura
No accesion number
Zihbin Xu, Sichun Zheng, Qili Feng
submitted to nomenclature committee April 17, 2011
80% to CYP304F1 Helicoverpa armigera
CYP304F4 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
99% to CYP304F4 Spodoptera litura (ortholog) 2 aa diffs
CYP304F5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
81% to CYP304F4 Spodoptera litura
CYP304F6 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
60% to CYP304F2 Zygaena filipendulae
CYP304F7 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP304G1 Trialeurodes vaporariourum (whitefly)
CYP304H1v1 Laodephgax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
41% to CYP304E1 Tribolium castaneum
CYP304H1v2 Laodephgax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
One amino acid diff to CYP304H1v1
CYP304H1v3 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
incomplete, 3 aa diffs to CYP304H1v1, 4 aa diffs to CYP304H1v2
Cyp305a1 Drosophila melanogaster
GenEMBL AC018013 comp(34574-37224)
Cyp305a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP305A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970235
41% to 305A1 Dm, 46% to 305A5 Aedes, 40% to 305B1 B. mori
MWLAVLLFFVFVVTYVIQQVKKPPNFPPGPYWLPFVGNLPQLKKLSKKLGGQHLALSHLAKEYNTNVLGL
KLGKDYVVTVFTYPLIRDVLISEEFEGRPDNFFLRLRCMGQKRGITCTEGEEWNTLRNFVNRHLRNLGFG
KKPMEKMIQDEICDILTILKKDGSDIQVDKFLAPCVLSVIWTLITGEKISRENNQLDELLDLFNLRSKAF
DMTGGTLTQYPWLRYFLPEWSGFNLIKSVNTSLKNLFMKYIREHKDGWFEGRNEDLIYRYISEMKTNTEA
SKYFTDDHLVMVCVDLFIGGAQTTSRTLGFAFLMMIMYPEVQKKVQEQIDKHYDKNSSIEYSDRYKLPYV
EAVLLETIRYRYVVPIGGPRRVTKNTTLDGYYLPKNTTVLISFYSINNDPENWQNPEIFNPERFLDEKGS
LLPDEKLIPFALGRRRCVGEILAKNCIFLLFVEILRRYNVSLAPGSKPPTGKPIAGITLSPESYRVKFTERSL
CYP305A1 part 1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 17
63% to CYP305A1 Tribolium castaneum
short N-term fragment
CYP305A1 part 2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 20
56% to CYP305A1 Tribolium castaneum
short C-helix fragment
CYP305A1 part 3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 3
51% to CYP305A1 Tribolium castaneum
middle region up to PKG motif
CYP305A1 part 4 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 22
62% to CYP305A1 Tribolium castaneum
short C-term fragment
CYP305A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph305, 45% to 305A1 Anopheles gambiae
Pediculus genome site
CYP305A2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPj2l1
CYP305A3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPj2l2
CYP305A4 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPj2l4
CYP305A5 Aedes aegypti (yellow fever mosquito)
XM_001654548
MIVLVLTSVLIIAFSYWLLQELRRPPNYPPGPQWLPFIGNTPFV
RKLARASGGQHLAFEALSKQYNSPVIGLKLGREYVVVALQYPAVREVHSKEEFDGRPD
NFFLRLRTMGTRLGVTCTDGPFWAEHRNFVVRHLRQAGYGRQPMQLQIQNELNELIGI
IRDMDGEPVWPGSILPTSVINVLWTFTTGSRIPRDDQRLARLLKLLQDRSKAFDMSGG
VLSQLPWLRHIAPEWTGYNLLKRFNQELHEFFMIIVERHHQEYHEEKCSDDLIYAFIK
EMKDRKDDPSSTFTDLQLTMIILDIFIAGSQTTSITIDLAFMMLTMHTDIQKKIHAEI
DENLHQDEMPQQNDRTSLPYTEAFLLEVQRFFHIVPVSGPRRALSDCTLGGYQIPKNT
TILMGLRTVHMDPEHWGDPECFRPERFLSPDGKIITTERLIPFGLGRRRCLGESLARA
CMFTFLVGILQKFSLRQPANCSEKPSPKLLPGITLSPKPYKVIFEPR
CYP305A6 Aedes aegypti (yellow fever mosquito)
XM_001654549
MITLVLSSVVIVSFIFWLWQDLQRPPNFPPGPKWLPFFGNTLLI
RNLARISGGQHLAFEALSKQYKSPVIGLKLGREHVVVALQYPAVHEALTKEAFDGRPD
NFFIRLRTMGTRLGITFTDGPFWTEHNSFVVRHLRQAGYGRQPMQLQIQNELNELIGI
IRDLDSEPVWPGSILPTSVINVLWTFTTGSRIPRDDQRLTRLLKLLQDRSKAFDMSGG
ILSQLPWLRHIAPEWTGYNLINRFNQEIHEFFKATIEKHHQDYTEEKCSDDLIYAFIK
EMKERKDDPCSTFTDVQLSMIILDIFIAGSQTTSTTIDIALMILAMNTEIQRKIYAEI
DDNFHPDEIPDQNCRTNLQYTEAFLLEVMRLYQIAPIGGPRRALSDCTLGGYRIPRNT
TILMGLHTVQMDPDHWGDPENFRPERFIGPDGKIINTERLIPFGLGRRRCLGDSLARS
CMFTFLVGILQKFSLRLPDSLEGPSLKLTPGITLSPKPYKVVFEPRLK
CYP305A7 Culex pipiens
CYP305A8 Culex pipiens
CYP305A9 Culex pipiens
CYP305A10 Culex pipiens
CYP305A11 Culex pipiens
CYP305A12P Anopheles gambiae (malaria mosquito)
GenEMBL XM_001230354.2 (seq below is expanded on both ends)
Partial cDNA sequence 97% identical to CYP305A3 and CYP305A4
Chromosome UNKN: 41,132,263-41,133,123 reverse strand.
This transcript is a product of gene AGAP012937
The genomic region 66760 bp upstream of this seq
is missing the N-term 140 aa, so this is a pseudogene.
GLGRQAMHEQIQTELTELLDVLDTRAEQPLWPGSILALS
VINVLWTIVTGSRVAREDDRLQRLLELLQERSKVFDMAGGTLNQLPWLRFIAPEWSGYNL
VRRFNKQLTKFFYPTIEEHKGDFTEDKAVDDLIYAYIKEMRDREGTSNNGNNFTEVQLTM
IILDIFIAGGQTTSATLDLALMMMIVHPEVQDKVHREIDSQLEPNAIPHYDDRLKLPYVE
AFLLEVQRYFSIAPVNGPRRAVVDCTLGGYRVPKDTTVLMGLRNVHMDPEHWGDPEVFRP
ERFLNEQRQIVNTERLLPFGQGKRRCLGETLARSCLFTFFVGVMKRF
CLMGTDEGSEDGTSMAPSLTLKPGITLSAKPYHVVSQPRR
CYP305A13 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
incomplete, 48% to CYP305A5 Aedes aegypti
CYP305B1 Bombyx mori (silkworm)
GenEMBL AB044900
Nobuyoshi Katagiri, Okitsugu Yamashita
39% identical to 305a1
CYP305B1 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ010a-v1Pep
after revision 61% to 305B1
CYP305B1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_201 38% to CYP305A3
(note: original CYP305C1 seq had an error in the mid region
name changed to CYP305B1 after revision)
CYP305B1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
54% to CYP305B2 Heliconius melpomene
62% to CYP305B1 Bombyx mori
CYP305B1 Plutella xylostella
Gene number CCG002515.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
64% to CYP305B1 Heliconius melpomene
CYP305B1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
79% to CYP305B1 Helicoverpa armigera
CYP305B1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
C-term 45% to CYP305B1 Heliconius melpomene
CYP305B2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
54% to CYP305B1 Heliconius melpomene
CYP305C1X Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee 12/30/2003
55% to CYP305B1
324 aa, seq #7
revised sequence name changed to 305B1
CYP305D1 Apis mellifera (honeybee)
CYP305D1 Linepithema humile (argentine ant)
No accession number
CYP305D1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
62% to CYP305D1 Linepithema humile
CYP305D1 Pogonomyrmex barbatus (seed-harvester ant)
No accession number
Reed Johnson
Submitted to nomenclature committee June 3, 2010
50% to CYP305D1 Apis mellifera
66% to CYP305D1 Linepithema humile
CYP305D1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP305E1 Acyrthosiphon pisum (pea aphid)
LOC100168939 SCAFFOLD13 coords:75476-86851
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
41% to CYP305A1 Drosophila melanogaster
CYP2 clan
MAWYFVCFVTVILLLIALRTCRKPKNYPPGPKWIPFVGNTYQLSKLAATKNGQYLAFEELRQRYKSDIIGLKLGREYVVIVFGNDLLNETFHRDEFQGRPDNFFMRLRTMGKRRGITMTDGDLWKVHRSFAVRHLKLLGLGQRRVDELIHDEYQLMVDRLFDATKSVTPTLYLQSAVMNVLWELTAGTKFEDPKLLTLMRKRSSAFDMAGGLLNQIPWLRYLAPTRTGFSLITEINQQLYSLISNIIVEHKKTITHTTRDFIDAYLNQMKKEEIYNTMFTEEQLIAVCLDLFIAGSSTTSSTLDFAILAMARWPDVQAKVQSTLDEIQPPGTYITAEQILKNRYVEAVLLETKRLNHVTPIIGPRRVLRNTNLNGYNIPKNTTILMSLYSVHQDQLKWGDPEVFRPERFMDTNGKINTTEDMYFFGFGKRRCPGEALAQRFVNLAFANLIHDFTIEIDQLPDGVNCGILLTPKPYKIKMTKRK
CYP305F1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
47% to CYP305A1 Tribolium castaneum
Cyp306a1 Drosophila melanogaster
GenEMBL AC012373 154223-156412 also AC015216 AC012164 AC012376
phantom phm gene
Cyp306a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
phantom phm gene
CYP306A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2r6
Ortholog of phantom phm gene
CYP306A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup13.1b
46% to 306A1 Drosophila. Note this sequence is
named in the same subfamily as other CYP306As since
there seems to be only one orthologous sequence per
species and it does not make sense to name orthologs with
different subfamily names.
Ortholog of phantom phm gene
CYP306A1 Linepithema humile (argentine ant)
No accession number
CYP306A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
62% to CYP306A1 Apis mellifera
CYP306A1 Solenopsis invicta (fire ant)
See Solenopsis page
79% to CYP306A1 Linepithema humile
CYP306A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
62% to CYP306A1 Apis mellifera
CYP306A1 Bombyx mori (silkworm)
BAAB01049676.1 BAAB01150476.1
BAAB01016115.1 BAAB01136488.1 BAAB01075467.1
AB162964
Niwa,R., Matsuda,T., Yoshiyama,T., Namiki,T., Mita,K., Fujimoto,Y.
and Kataoka,H.
CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid
biosynthesis in the prothoracic glands of Bombyx and Drosophila
J. Biol. Chem. (2004) In press
See silkworm page for sequence
Ortholog of phantom phm gene
CYP306A1 Manduca sexta (tobacco hornworm)
GenEMBL DQ357066
Rewitz,K.F., Rybczynski,R., Warren,J.T. and Gilbert,L.I.
Identification, characterization and developmental expression of
Halloween genes encoding P450 enzymes mediating ecdysone
biosynthesis in the tobacco hornworm, Manduca sexta
Insect Biochem. Mol. Biol. 36 (3), 188-199 (2006)
MDLFFIWLVTFVAGFWICKKIKEWQNLPPGPWGLPILGYLPFID
PRQPHITLTKLSKLYGPIYGLKMGNIYAVVLSDHKLIRDAFAKENFSGRAPLYLTHGI
MHGNGIICAEGGLWKDQRKLITTWLKSFGMSKHSALRDKLEKRIASGVYELLDSIEKS
PKEPIDLPHMVSNSLGNVVNEIIFGFKFPSDDKTWQWLRQIQEEGCHEMGVAGVVNFL
PFVRFFSPTIRKTIQMLIRGQAQTHTLYASVIARRRNMLGLEKPKGAEHLPHSNLFNE
YPDGKLKCIKYSKHAPNTEHIFDPKTLIPTEGECILDSFLLEQKKRFENGDETARYMT
DEQLHFLLADMFGAGLDTTSVTLAWFLLYMALYPDEQEIVRKEILSEYPEECEVESSR
LPRLMAAIYETQRIRSIVPVGIPHGCLEDTYLGNYKIPKGAMVIPLQWALHMDPDVWE
DSEEFKPSRFLAPDGSLLKPQEFIPFQTGKRMCPGDELSRMLASGFIARLFRRKRVRL
ASIPSQEDMQGTVGVTLAPPRVQYFCDPI
CYP306A1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP306A1 Chilo suppressalis (striped rice stem borer)
No accession number
Jifeng Shi
Submitted to nomenclature committee May 1, 2012
80% to CYP306A1 Spodoptera littoralis
CYP306A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_197 79% to CYP306A1 Bombyx
HAH005766 100% to Contig_197
CYP306A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
71% to CYP306A1 Spodoptera littoralis
CYP306A1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
93% to CYP306A1 Helicoverpa armigera
CYP306A1 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
95% to CYP306A1 Helicoverpa armigera
CYP306A1 Spodoptera littoralis (cotton leafworm)
FJ010194
CYP306A1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
98% to CYP306A1 Spodoptera littoralis FJ010194
CYP306A1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP306A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_968477, protein and AAJJ01000667.1 genomic
46% to 306A1 Aedes, 49% to Apis 306A1
Ortholog of phantom phm gene
MAPLWSVLLSFLLFIIAYTWLRRSRNLPPGPWNLPVIGYLAWLNPQFPYLTLTSLSKKYGPIYGLYLGSI
YTVVISDAKLIKKTFNKDASSGRAPLHLTHGIMKGFGLICAQGDLWKDQRKFVHNTLRTLGASKVSPNRP
TMEALILHHVSDLVQHIKSLGESVTLDPLDSLRHSLGSAINQMVFGKCWSRDDATWKWLQHLQEEGTKHI
GVAGPLNFLPLLRFLPKSKQTINFLTEGIRDTHQIYREIIEEQKNSSNETVSNVIQAFLAEKEKRKNEDS
VKFYNDQQFHYLLADIFGASLDTTLTTLRWYVLYMAVHQDVQKKVRSLLNDLTLEQIAMVPYFEATIAEV
QRIRPVVPVGIPHGSVEELEIAQYKVPPGTMIVPLQWAVHMDANIWDEPEVFKPERFINEEGKFFKPEAF
IPFQAGKRMCVGDELARMFLYLFGAALVKNFAISCMGEVDLTGDCGITLTPKPHELIFTSL
CYP306A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010 revised Nov. 22, 2011
CYP2 clan
Clone name seq 8
56% to CYP306A1 Tribolium castaneum
complete
CYP306A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
54% to CYP306A1 Leptinotarsa decemlineata
CYP306A1 Aedes aegypti (yellow fever mosquito)
CYP306A1 Culex pipiens
CYP306A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph306, phm phantom 51% to 306A1 Apis
Pediculus genome site
CYP306A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP306A1 Acyrthosiphon pisum (pea aphid)
LOC100165691
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
phm 25 hydroxylase
CYP2 clan
MFWIIGVILFGVLCAGYLWRSNRNLPPGPWGVPIFGYLPWLNPTEPYKTLTALASKYGPIYSIQMGKHFAVVMSDPTLVRMALARNELADRTNFEVVNEIMQEHGLIFTHGPLWKEQRKFVCNWLKVIGVTKFGDKKNNLQLLIADAVSTTISKLRQSNNRPIDTGTFFLVHIGDFINLIVLGKAWPEDDPNWIYLRNLAEDGSKKFAIATPLSVLPILKIIPKYRNTVFEVIEGVKNTHLIYKTLMEKRGNEIHESDDLMAMFMKEMTKRKNDKDSHYFTEKQCCFLLSDLFGAGVETTVNTLRWFLLYMALNQEIQNDLQKLLDSACTDGGLIGLEQIESIPLLKACVSETMRLRPVAPSGIPRSVNTEITISGYRIPKGTMVLPLQWAMHHDEKYWTDPETFRPKRFLDDEGNMINHKAFMPFQAGKRACVGDTLSYWILYLFGANIIHNFNVSAEQGLSEKEINTIMDGEFGITLSPATHKVVFKSRI*
CYP306A1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
N-term and C-term 50-51% to CYP306A1 Apis and Nasonia
CYP306A1v1 Trialeurodes vaporariourum (whitefly)
CYP306A1v2 Trialeurodes vaporariourum (whitefly)
CYP306A1 Daphnia pulex (water flea)
CYP306A1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
62% to CYP306A1 Trialeurodes vaporariourum (whitefly)
CYP306A1 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf58 C-terminal
53% to CYP306A1 Apis
CYP306A2 Laodelphax striatellus (small brown planthopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee June 22, 2011
Clone name scaffold22645 C-term
52% to CYP306A1 Aedes
note: species corrected from Sogatella frucifera
(white-backed plant hopper)
CYP306A2 Laodelphax striatellus (small brown planthopper)
No accession number
Complete sequence sent by Jia Shuang
Submitted to nomenclature committee Dec. 6, 2011
CYP306A1/2 Laodelphax striatellus (small brown planthopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee June 22, 2011
Clone name scaffold30570 N-term
49% to CYP306A1 Spodoptera littoralis
note: species corrected from Sogatella frucifera
(white-backed plant hopper)
CYP306A2a Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
N-term part 93% to CYP306A2 Laodelphax striatellus
CYP306A2b Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
C-term part 84% to CYP306A2 Laodelphax striatellus
Cyp307a1 Drosophila melanogaster
GenEMBL AC014810 comp(54284-52654) also AC007840
spook spo (see Flybase)
307a1 AC014810 comp(54284-52654) also AC007840 revised 9/8/2000
sequence revised between PERF and heme, no intron is present
MLAALIYTILAILLSVLATSYICIIYGVKRRVLQPVKTKNSTEINHNAYQKYTQAPGPRP
WPIIGNLHLLDRYRDSPFAGFTALAQQYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKV
MSGRPDFIRYHKLFGGERSNSLALCDWSQLQQKRRNLARRHCSPREFSCFYMKMSQIGCE
EMEHWNRELGNQLVPGEPINIKPLILKACANMFSQYMCSLRFDYDDVDFQQIVQYFDEIF
WEINQGHPLDFLPWLYPFYQRHLNKIINWSSTIRGFIMERIIRHRELSVDLDEPDRDFTD
ALLKSLLEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLVLAYIAKNVDIGRRIQEEIDAII
EEENRSINLLDMNAMPYTMATIFEVLRYSSSPIVPHVATEDTVISGYGVTKGTIVFINNY
VLNTSEKFWVNPKEFNPLRFLEPSKEQSPKNSKGSDSGIES
DNEKLQLKRNIPHFLPFSIGKRTCIGQNLVRGFGFLV
VVNVMQRYNISSHNPSTIKISPESLALPADCFPLVLTPREKIGPL
Cyp307a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
spook spo (see Flybase)
D. pseudoobscura ortholog of Cyp307a1 Jie Shen no introns
MSAVYSVLAILLAIIITSYIRILYKSRRRVCVAIRNGKSSTESEQIYEQAPGPRPWPIIG
NLNVLDKYRDNPFEGFTELAKKYGDIYSLTFGHTRCLVVNNLELIREVLNQNGKVVSGRP
DFLRYHKLFGGERSNSLALCDWSQLQQKRRNMARRHCSPRESSSFYMQMSQIGCEEMEHF
IREIDAKMVPGEPFDVKTFLLRACANMFSQYMCSQRFDYDDEEFHKIVQYFDEIFWEINQ
GHPLDFLPWLYPFYRRHLNKIVHWSSTIRSFIMDRIISHRELDIDVDEPDSDFTDALLKS
LVEDKDVSRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPQVGRRIQDEVDAVSSKGQR
KINLLDMHQMPYTMATIFEVLRYSSSPIVPHVATEDLVISGHGVTAGTIVFINNYVLNRS
REHWEDSHQFEPQRFLEPSTEGRRDSRGSDSGIESDQKEFQLRKNIPHFLPFSIGKRTCI
GQNLVRGFGFLLLANLLQGYNVSSGDPTTIRITPASLALPASCFPLLLTRRA*
CYP307A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x4
Ortholog of spook spo (see Flybase)
CYP307A1 Bombyx mori (silkworm)
BAAB01102325.1 BAAB01020228.1
51% to 307A1 probable ortholog
See silkworm page for sequence
Ortholog of spook spo (see Flybase)
CYP307A1 Manduca sexta
GenEMBL DQ899315
Ono,H., Rewitz,K.F., Shinoda,T., Itoyama,K., Petryk,A.F.,
Rybczynski,R., Jarcho,M., Warren,J.T., Marques,G., Shimell,M.J.,
Gilbert,L.I. and O'Connor,M.B.
Spook and Spookier code for stage-specific components of the
ecdysone biosynthetic pathway in Diptera
Dev. Biol. (2006) 298, 555-70.
MSVLLIIAVAVYAIYKYFSKTKILWRKSNKYGKEEVEVLREAPG
PFPLPVVGSLHLLGRHESPFQAFTALAKEYGDIYSIKLGSAKCLIVNNLALIREVLNQ
NGNFVAGRPDFLRFHKLFAGDRNNSLALCDWSNLQLRRRNLARRHCGPKQHTDFYARI
GSVATLESYELVQTLKSITQTTEQSINLKPLLMTSAMNMFTNYMCSVRFDENDSEFRK
VVDHFDEIFWEINQGYAVDFLPWLAPFYKKHMDKLSGWSQDIRSFILSRIVEQREMNL
DMEGPEKDFLDGLLRVLHEDPNVDRNTIIFMLEDFLGGHSSVGNLVMLCLTAVARDPE
IGRKIRAEIEGVTKGKRPVALTDRSNLPYTEAAILECLRYASSPIVPHVATENAKING
YGVEKGTVIFINNYVLNNSEQYWNNPENFDPSRFLEKTKVRTRRNSQCDSGMESDSER
SPSKETETEVYSVKKNIPHFIPFSIGKRTCIGQTLVTTMSFTMFANIIQEFDVGVENL
DDLIQKPACVALPKDTYNMYLIPRKQ
CYP307A1 Chilo suppressalis (striped rice stem borer)
No accession number
Jifeng Shi
Submitted to nomenclature committee May 1, 2012
79% to CYP307A1 Spodoptera littoralis
frameshift near N-term and stop codon in heme region
incomplete sequence, probably with two errors
CYP307A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_269 73% to CYP307A1 Bombyx, 56% to CYP307A1 Anopheles
HAH014257 100% to Contig_269
Submitted sequences contain an intron
CYP307A1 Plutella xylostella
Gene number CCG007583.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
77% to CYP307A1 Heliconius melpomene
CYP307A1 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01000951.1 genomic
55% to 307A1 Anopheles
Ortholog of spook spo gene
MLALLCLCVVLLVWWFSRPKKSPSTI
33251 PGPRPWPLIGSMHLLAGHETPFQAFTALSRVYGDIFSIHLGSASCVVVNNFKLIKEVLIA 33430
33431 KGGDFGGRPDFARFHKLFGGDRNN (1) 33502
34320 SLALCDWSSLQKTRRSIARTYCSPRFTSLQYDRVNNVGEEELKSFLHQLDQLPHGQPC 34493
34494 NVKPAVLMVCANMFTQYMCSTSFAYEDKGFQKIVRYFDEIFWEINQGYAVDFLPWLLPVY 34673
34674 TGHMKKISNWATEIRQFILSRIIDKHRATLDTNSPPRDFTDALLMHLEEDPNMNWQHIIF 34853
34854 ELEDFLGGHSAIGNLVMVTLAAVVDHPEVAKRIQEEVDQVTGGTRCPNLFDKAAMPYTE 35030
35031 ATILETLRTASSPIVPHVASKDTEIDGHEVSKGTIVFINNYELNQGDAYWDEPGLFKPER 35210
35211 FLSSTGNIVKPAHFIPFSTGKRTCIGQRLVQCFSFVVLATLLQYYDVSTKESVK 35372
35373 VQPGCVAVPPDCFKLVLTPRK* 35438
CYP307A1 part 1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 21
75% to CYP307A1 Tribolium castaneum
aa 39-91
CYP307A1 part 2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 28
67% to CYP307A1 Tribolium castaneum
aa 226-360
CYP307A1 part 3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP2 clan
Clone name seq 25
60% to CYP307A1 Tribolium castaneum
aa 432-482
CYP307A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
70% to CYP307A1 Tribolium castaneum
CYP307A1 Aedes aegypti (yellow fever mosquito)
CYP307A1 Culex pipiens
CYP307A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph307-2, spo spook 66% to 307A1 Tribolium
Pediculus genome site
CYP307A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP307A1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
Partial sequence
63% to CYP307A1 Tribolium castaneum
CYP307A1 Laodelphax striatellus (small brown planthopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Oct. 12, 2011
Complete sequence
57% to CYP307A1 Pediculus humanus
CYP307A1a Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
N-term part 94% to CYP307A1 Laodelphax striatellus
CYP307A1b Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
C-term part 92% to CYP307A1 Laodelphax striatellus
CYP307A1 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0093H16
60% identical to Dm CYP307a1 ortholog
CYP307A1 Acyrthosiphon pisum (pea aphid)
LOC100160204
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
85% to LOC100160738
57% to CYP307A1 Tribolium, 49% to Cyp307a2 Drosophila melanogaster
39% to CYP307B1 Tribolium
CYP2 clan
MDTAKGVVAAAADNVTVVLLLLLSVVLLILAVKSASGRGPWTSRRRPGKSTAAVALTAVPDGPTAYPVIGALHAMDGHRDKPFHRFTELSHKYGPVFSMTMGSMPCVIVNDFDSIKEVLITNGSKFGGRPDFSRYNVLFAGDRNNSLALCDWSWLQETRRKIARKYCSPKVCSSNYGLLDSISSDELDVFLESLAAVTIRGFECEVQLKKQLLMACANMFIRFMCSTQFEYGDPKFQNMVRTFDEIFWDINQGYAVDFLPWLKPFYAGHMRKLSKWSTQIRRFIMDTVVSKRYAADDVDEQEPIDFTDALLMSLRKEPGLKMNHVLFELEDFIGGHSAVGNMIMLALSMVATRPHVAQAIRDEAEQVTGGQRLVRLYDKPDMPYTEATLFETLRFISSPIVPHVATEDTTIKGFKISKGTCIIINNYEINTSPAYWDNPEVFDPNRFVHRESGTKPCIRKPEYFLPFSTGKRTCIGQQLVSGFGFVLLAGILQRYEVKATAQLAIPEARLALPPDTYPLILKPLDGSR
CYP307A1v1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP307A1v1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP307A1 Daphnia pulex (water flea)
Cyp307a2 Drosophila melanogaster
GenEMBL AC019383 comp(3284-3706) AL078186
This sequence was originally predicted as a pseudogene,
but recent work shows it is a functional gene called spookier (spok)
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho
M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB.
Spook and Spookier code for stage-specific components of the ecdysone
biosynthetic pathway in Diptera.
Dev Biol. 2006 Oct 15;298(2):555-70.
This is a new member of the halloween genes
AC019383 comp(3284-3706) AL078186
AC019474 exon 2
MLTSVFYVLFAIAITIILISYVFLLLKCKQKAFVVIGLLYQEKKYQCFDQAPGPHPWPII
GNINLLGRFQYNPFYGFGTLTKKYGDIYSLSLGHTRCIVVNNVDLIKEVLNKNGKYFGGR
PDFFRYHKLFGGDRNN (1)
663 SLALCDWSQLQQKRRNLARRHCSPRESSSYFSKMSEIGGLEVNQLLDQLTNISSGYPCDV 842
843 KPLILAASANMFCQYMCSVRFNYSDKGFQKIIEYFDEIFWEINQGYSFDYIPWLVPFYCN 1022
1023 HISRIVHWSASIRKFILERIVNHRESNININEPDKDFTDALLKSLKEDKNVSRNTIIFML 1202
1203 EDFIGGHSAVGNLVMLALAYIAKNPTIALHIRNEVDTVSAKGIRRICLYDMNVMPYTMAS 1382
1383 ISEVLRYSSSPIVPHVAMEDTVIKGFGVRKGTIVFINNYVLNMSESFWNHPEQFDPERFL 1562
1563 ENNFTNNKESGLKCDDNKRTEFIRKNDNDGSTKSKKYGKQNLNNK 1697
1698 LLKKSIPQFLPFSVGKRTCIGQSLVRGFGFLLLANIIQNYNVNSADFSKIKLEKSSI 1868
1869 ALPKKCFKLSLRPRT* 1916
Cyp307a2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Contig3286_Contig7811B.fa.9 66% to D. pseudoobscura ortholog of 307A1
first exon 67% to 307A2 55% to 307A1 so this is the ortholog of 307A2
sequence revised between PERF and heme (no intron), not a pseudogene
MFFSVCYLIIAIGITAIVISYILIIFKCNEKATVRIGLSNPEKAIRKFGQ
APGPQPWPIIGNLDLLGRFKSNPFEGLGALTKQYGDIYSLTLGHSRCLVV
NSLDLIREVLNKNGKFIGGRPDFIRYHKLFGGDRNN (1)
SLALCDWSNLQQKRRNLARRH
CSPRESSPYFNKMSHIGCNEINHLMRELNKTQPGKPFDIKKLILGASANM
FCQYMCSIRFDYNDKEFRRIVRYFDEIFWEINQGYSLDFLPWMLPFYKNH
TQKIVQWSTTIRKFILDRVIHQREEMLDLDEPENDFTDALLRSLKEDQNV
SRNTIIFMLEDFIGGHSAVGNLVMLALAYIAKNPMIGRRIEHEADIVTNK
GRRRINLYDMDAMPYTMATIFEVLRYSSSPIVPHVAMEDTAIAGFGVTRG
TIIFINNYMLNMSEKYWNSPDHFEPERFLDENYRRNIWKAVKCNDN
RRGSEGSDSGIEFEKDTHVHKIIIDKLTSTKNSKKNKNIFNDKCGY
QLKKNIPHFLPFSIGKRTCIGQNLVRGFGFVLLANIVQSYNITSADISKININH
ESLALPADCFPLVLTPRA*
CYP307A3 Acyrthosiphon pisum (pea aphid)
cLOC100160738
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
52% to CYP307A1 Tribolium, 50% to Cyp307a2 Drosophila melanogaster
37% to CYP307B1 Tribolium
CYP2 clan
MDTTNGIVAGADTVTVALSLLLPVVLLMLAVAWACGPLAAHRRPGTSTAAVLDGPKSFPIIGSLHAMDGHQDSPFRRFTELSHQYGPVFAMTMGSMPCVVVNDYDSIKEVLITNGSKFGGRPDFTRYNALFAGDRNNSLALCDWSSLQETRRKIARTYCSPKVYSSNYCLLDSISSNELDVFLDSLATVSVRGSECEVQLKQLLLMASANMFIRFMCSTQFEYGDPEFQNMVRTYDEIFWDINHGYAVDFLPWLKPFYAGHMRKLSKWSTQIRQFIMDMVVSKRSSYAKAQEPTDFTDALLMSLRKEPGLKMNHVLFELEDFIGGHSAVGNMVMLALSMVATRPHVAQAIRDEAEQVTGGQRLACLYDKPDMPYTEATLLETLRFISSPIVPHVATEDTTIKGFKISKDTCIIINNYEINTSPAYWDNPEVFDPNRFVHRKFGAKPCIRKPEYFLPFSTGKRTCIGQQLVSGFGFVLLAGVLQRYEVKATAELAIPEARMALPPDTYPLILKPLDGSR
CYP307B1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3r2
Note: CYP307B sequences have been named spookiest
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho
M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB.
Spook and Spookier code for stage-specific components of the ecdysone
biosynthetic pathway in Diptera.
Dev Biol. 2006 Oct 15;298(2):555-70.
CYP307B1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.9
55% to 307B1 Anopheles. Note this sequence is given the
same name as Anopheles 307B1 since
there seems to be only one orthologous sequence and it does
not make sense to name orthologs with different names.
Note: CYP307B sequences have been named spookiest
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho
M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB.
Spook and Spookier code for stage-specific components of the ecdysone
biosynthetic pathway in Diptera.
Dev Biol. 2006 Oct 15;298(2):555-70.
CYP307B1 Linepithema humile (argentine ant)
No accession number
CYP307B1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
70% to CYP307B1 Apis mellifera
CYP307B1 Solenopsis invicta (fire ant)
See Solenopsis page
88% to CYP307B1 Pogonomyrmex barbatus
CYP307B1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
71% to CYP307B1 Apis mellifera
CYP307B1 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01001163.1 genomic
53% to 307B1 Anopheles, 55% to 307B Aedes, 51% to bee 307B1
Note: CYP307B sequences have been named spookiest
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho
M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB.
Spook and Spookier code for stage-specific components of the ecdysone
biosynthetic pathway in Diptera.
Dev Biol. 2006 Oct 15;298(2):555-70.
13728 MFFTQFTLYLIAFVVLATVFAIAEAMRTRQGKY
13629 RPPSPLKLPIIGHLHLMSGYQVPYQAFTSLSKKFGSVFGLQLGYVKCVVINGQKNIREAL 13450
13449 VTKGHHFDSRPNFERYQQLFSGNKEN (1) 13372
13324 SLAFCNWSTTQKTRRDMLKAYTFPRAFTNRFYTLEELVSSGTRSVVAALSTNTTSTKSV 13148
13147 ISRHCANIFTRHFCSKSFDVDEATFVEMVDNYDEIFYEVNQGYAADFLPFLLPFHEKNLK 12968
12967 RVNGLTHKIRDFVLDHIIEGRFDSFDVQAEPDDYVESLIKYVKSGESPQLSWDSALFALE 12788
12787 DIIGGHSAVANFLVKLFAFLAKEPQVQENIHKEIDRVLGTKEVSISHRTLLPYTEAT 12617
12616 IFEAIRLIASPIVPRVANRDSSIN (1) 12545
12489 GLEIEKGTVIFLNNYDLSMSPQLWDEPEKFKPERFIRE 12376
12375 ERLVKPEHFLPFGGGRRSCMGYKMVQLVSFGILGGIMQNFTIGADDTSYTVPVGSLALP 12199
12198 KDTFTFKFVRR* 12163
CYP307B1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
61% to CYP307B1 Tribolium castaneum
CYP307B1 Aedes aegypti (yellow fever mosquito)
Note: CYP307B sequences have been named spookiest
Ono H, Rewitz KF, Shinoda T, Itoyama K, Petryk A, Rybczynski R, Jarcho
M, Warren JT, Marques G, Shimell MJ, Gilbert LI, O'Connor MB.
Spook and Spookier code for stage-specific components of the ecdysone
biosynthetic pathway in Diptera.
Dev Biol. 2006 Oct 15;298(2):555-70.
CYP307B1 Culex pipiens
CYP307B1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph307-1, spookiest 47% to 307B1 Apis
Pediculus genome site
CYP307B1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig5856_11021 546aa
53% TO CYP307B1 Anopheles, in the CYP2 clan
CYP307B1 Cimex lectularius (bedbug)
No accession number
Hemant Gujar
Submitted to nomenclature committee Aug. 1, 2011
CYP307B1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Sept. 17, 2011
57% to CYP307B1 Cimex lectularius
CYP307B1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
57% to CYP307B1 Cimex lectularius (presumed ortholog)
complete
CYP307C1 Acyrthosiphon pisum (pea aphid)
LOC100159333
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
46% to CYP307B1 Tribolium, 43% to CYP307A1 Tribolium,
40% to CYP307A2 D. melanogaster
42% to CYP307A1 aphid, 40% to CYP307A3 aphid
CYP2 clan
MEFVFSSLTYLLLFVLTAVLLFLIRDELKTKQVDHRAGLVDPPAPKAWPIIGHLYLMARYKVPYRVFDEIMADLGSVFRLDLGSVPCVVVNGLNNIREVLMIKGDHFDSRPSFRRFNQLFKGDKNNSLAFCDWSQLQKTRRELLRAHTFPNTTSNMYTRLDTCLKTELADLTDTLDTMANTECVDIKNMLLHTCANVFMSYFCSTRFSRSYDKFREFIRNFDDVFYEVNQGAPCDFLPSLMPLYHWHFKKIRSWSSKIRNFMETEIFNKRKAAWVPGTKPVDFVDNLLDAVTQPDRDDGFDMDIGLFSLEDIIGGHSAITNFIVKTLGFLVDRPDVQRRIQEESDAVVRASGSVGLSDRSQMPYTEAVVYESLRLIASPIVPHLANRDTSVDGVRIRKGTTVFLNNYSLHMSPELWNNPEHYSPERFINAEGRLEKPEYFIPFSGGKRSCMGYKLVQLLSFCTISTLLNKYTLLPVEDVSYAVPKGNLALPFVTFPFRLRPRNFRKQ
CYP307D1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
Cyp308a1 Drosophila melanogaster
GenEMBL AC015216 72624-74273 also AC012164
Cyp308a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp309a1 Drosophila melanogaster
GenEMBL AC019891 comp(47437-49308) also AC009909
Cyp309a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp309a2 Drosophila melanogaster
GenEMBL AC009909 45541-45982 also AC019977
Cyp309a2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP309B1 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
39% to Cyp309a1 D. pseudoobscura
38% to Cyp309a2 D. melanogaster
36% to Cyp28a5 D. melanogaster
clone name 1138
Cyp310a1 Drosophila melanogaster
GenEMBL AC017690 comp(12877-14650)
Cyp310a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp311a1 Drosophila melanogaster
GenEMBL AC014186 2270-3910
Cyp311a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp312a1 Drosophila melanogaster
GenEMBL AC015424 57845-59744 also AC009369 AC007573 AC010003
Cyp312a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp313a1 Drosophila melanogaster
GenEMBL AC017740 comp(167857-169728) also AC007809 AC007928
Cyp313a2 Drosophila melanogaster
GenEMBL AC017371 4100-5929 AC007724 AL057969 AL067059
Cyp313a3 Drosophila melanogaster
GenEMBL AC017371 1890-3720 also AC007724
Cyp313a4 Drosophila melanogaster
GenEMBL AC017336 153877-155807 also AC007752
Cyp313a4 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp313a5 Drosophila melanogaster
GenEMBL AC017371 6352-8145 also AC007724
Cyp313a6 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
This is a paralog of 313a4, D. pseudoobscura has two genes
To D. melanogasters one Cyp313a4
Cyp313b1 Drosophila melanogaster
GenEMBL AC007571 comp(104264-106046) also AC013225
Cyp313b1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp313c1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp313c2 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp314a1 Drosophila melanogaster
GenEMBL AC012699 22585-24723 also AC006496
shade shd gene
Cyp314a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
shade shd gene
CYP314A1 Bactrocera dorsalis (oriental fruit fly)
JQ229645
Lin Cong
Submitted to nomenclature committee 12/5/2011
69% to CYP314A1 D. melanogaster
CYP314A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2r3
Ortholog of shade shd gene
CYP314A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup5.25
43% to 314A1 Drosophila. Note this sequence is
named in the same subfamily as other CYP314s since
there seems to be only one orthologous sequence per
species and it does not make sense to name orthologs with
different subfamily names.
Ortholog of shade shd gene
CYP314A1 Linepithema humile (argentine ant)
No accession number
CYP314A1 Solenopsis invicta (fire ant)
See Solenopsis page
92% to CYP314A1 Pogonomyrmex barbatus
CYP314A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
87% to CYP314A1 Linepithema humile
CYP314A1 Acyrthosiphon pisum (pea aphid)
GenEMBL CF588143
48% to 314A1 Dros. Pseudoobscura aa 126-362
Ortholog of shade shd gene
CYP314A1 Trialeurodes vaporariourum (whitefly)
CYP314A1 Laodephgax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
65% to CYP314A1 Cimex lectularius (bedbug)
CYP314A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
complete
CYP314A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_972699, CB336479 CB336480 EST
42% to 314A1 bee, 39% to 314A1 Aedes
Ortholog of shade shd gene
MFEKIFQSLDVTSLLIIAIFFLFLEYRPPWWYRNNDCKKGVKLIPGPLALPGLGTTWIFFFGGFSFNRLH
LYYENMYKRYGPVMKEEYWCNIPVINLFEKREIVKVLKAGGKYPLRPPVEAVAHYRRSRPDRYASIGLVN
EQGEAWYDLRSTLTPALTSPKTITSFLPEAQQIADDWCNLLKLSRDKNGRVSNLNYIADRLGLELTCALV
LGRRMGFLLPGAETETGEKLAEAVRQHFLGTRDTYFGFPFWKLFPTPAYKTLIKSEASIYELALELINSA
NESTKESAVFQSVIQAEIDEREKIAAIIDFISAGIHTMKNSLLFLLHLIGQDLQIQKKIIEDSTKSYSKA
CVTETFRLLPTANALGRILEEEMELGGYRLSAGTVVVCHFGIACRDERNFPDASKFKPERWLDDDKVQTA
TNSLFLLTPFGAGRRICPGKRFIEHILPLLLESTVNSFEIQAEEELELQFEFLVTPKGQMPMVFKDRV
CYP314A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 45
52% to CYP314A1 Tribolium castaneum
PKG to PERF fragment
CYP314A1 Aedes aegypti (yellow fever mosquito)
CYP314A1 Culex pipiens
CYP314A1 Culex_quinquefasciatus (southern house mosquito)
No accession number
Osamu Komagata
submitted to nomenclature committee 7/25/07
sequence 26
62% to CYP314A1 Anoph., 76% to 314A1 Aedes
Ortholog of shade shd gene a halloween gene in the Mito clan
CYP314A1 Bombyx mori (silkworm)
BP179750 BP179443 BAAB01069738.1 BAAB01063661.1
BAAB01099804.1 BAAB01099804.1 BAAB01122030.1 BAAB01134118.1
49% to 314A1 probable ortholog
See silkworm page for sequence
Ortholog of shade shd gene
CYP314A1 Manduca sexta (tobacco hornworm)
GenEMBL DQ372988
Rewitz,K.F., Rybczynski,R., Warren,J.T. and Gilbert,L.I.
Developmental expression of Manduca shade, the P450 mediating the
final step in molting hormone synthesis
Mol. Cell. Endocrinol. 247 (1-2), 166-174 (2006)
MSLPGVFLFSYYMKNVWSTPTPLLDWSCVPTLVLLVALVVVTVT
AVLTRAVDTKNPSRLPGPQPLPFLGTRWLFWSRYKMNKLHEAYEDMFRRYGPVFAETT
PGGATIVSIADREALDAVLKAPAKRPYRPPTEIVQVYRRSRPDRYASTGLVNEQGDKW
LHLRRHLTVELTSPNTMQGFMPELNSICEDFLDLLQSSRQANGTVHGFDQLTNRMGLE
SVCGLMLGSRLGFLERRMSGRAATLAAAVKTHFRAQRDSYYGAPLWKFAPTTLYKTFV
RSEETIHTVVSELMEEAKARTNGSAKDDGMQEIFLRILENPALDMRDKKAAVIDFITA
GIETLANSLVFLLYLLSGRPDWQHTIRSELPSCSRLSADDLSAAPSVRAAINEAFRLL
PTAPFLARLLDTPMTLGGHKLPAGTFVLAHTGAACRREENFWRAHEFLPERWSSSRQP
HAASLVAPFGRGRRMCPGKRFVELELHLLLAKIMQRWRVEFDGELDVQFDFLLSPKSP
VTLRLVEW
CYP314A1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP314A1 Plutella xylostella
Gene number CCG011058.5
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
79% to CYP314A1 Manduca sexta
CYP314A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph314, 51% to 314A1 Apis
ortholog to shd shade
Pediculus genome site
CYP314A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP314A1 Daphnia magna (water flea)
GenEMBL AB257771
Yoshinori Ikenaka
Submitted to nomenclature committee 8/28/06
CYP family-1, full length sequence
41% to Cyp314a1 Drosophila, 40% to Apis CYP314A1
probable ortholog so the same subfamily name is used
CYP314A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig11074 414aa
58% TO CYP314A1 aphid, in the mito clan
CYP314A1a Acyrthosiphon pisum (pea aphid)
LOC100167431 SCAFFOLD4030:67656..77815 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
45% to CYP314A1 Manduca sexta
mito clan
MVQKNFWTKIGGACCIVVACITALVKLVLKYVVGTYSNVEYPSEAQQKIYKTIADIPGPRSLPVFGTRWIYWKFCLYKLNAVHLAYEDMFNRYGDIIREEALWNIPVISVKNRDFIERVLRQSGKYPIRPPNEVTANYRKSRPDRYTNTGLVNEQGEVWAMLRNKLTPELTSPRTIRRFLPEVNQLADDFNNLISLARDGNNVVKEFEAYCNRMGLESTCTLILGRRFGFLDGEISETATRLADSVTSQFRASQEAFYGLPLWKLIPTKAYKDFVASEDALYNIVSEIVDSALIDEQQSCTDVRSVFVSILQTSELDNRDKKAAIIDYIAAGIKTLGNTLVFLLYLVAKHPEVQEKIYNEISRLAPAGTSVTAEHLHKATYLRACITEAHRLKPTAPCIARVLESEIEYDNYRLPPGSVVLLHTGLACLDENNFKDATSYRPERWLDELTKKSPFLVAPFGCGKRMCPGKRFVDLELQIVLAKMVKQFEIDFEGQLKTEFEFLLTPVDSNFILRDRIC*
CYP314A1b Acyrthosiphon pisum (pea aphid)
LOC100165833 SCAFFOLD10596 coords:34935-48215 (+) strand
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
94% to CYP314A1a aphid, 66% to CYP314A2 aphid
44% to CYP314A1 Manduca sexta
a recent gene duplication may include some flanking genes as well
mito clan
MVQKNFWTKIGSACCIVIACITTLVKLVLKYVVGTYSNHENPSDAQQKIYKTIADIPGPRALPFFGTRWIYWKFCLYKLNAVHLAYEDMFNRYGDIICEEALWNIPVISVKNRDFIERVLRQSGKYPIRPPNEVTANYRKSRPDRYTNTGLVNEQGEVWAMLRNKLTPELTSPRTIRRFLPEVNQLADDFNNLISLARDGNNVVRGFEGYCNRMGLESTCTLILGRRIGFLDGEVSETATRLADSVTSQFRASQEAFYGLPLWKLIPTKAYKDFVASEDALYDIVSEFVESALIDEQQSFTDVRSVFVSILQASELDNRDKKAAIIDYIAAGIKTLGNTLVFILYLVAKHPEVQEKIYNEVSLLAPAGTPITSEHLHKATYLNACIIEAHRLKPTAPCIARVLESEIEYDNYRLPPGTVVLLHTGLACLDENNFKDATSYRPERWLDELAKKSPFLVAPFGCGKRMCPGKRFVDLELQIVLAKMVKQFQIDFEGQLKTEFEFLLTPVDSNFILRDRIY*
CYP314A1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
54% to CYP314A1 Tribolium castaneum
clone name DPO1117_G11
CYP314A1 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf48 and sf64 two pieces probably from the same gene
~60% to CYP314A1 aphid (partial sequence)
CYP314A Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
Complete seq. 95% to CYP314A1 Laodelphax striatellus
CYP314A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP314A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP314A1 Daphnia pulex (water flea)
CYP314A2 Acyrthosiphon pisum (pea aphid)
LOC100169172 SCAFFOLD543:7676..15068 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
40% to CYP314A1 Manduca sexta
mito clan
MALQKIIRKIWTSIKVTCFIVLACVTALVKFVSKNTLGIYRKFRKPADAQRRIYKTVADIPGPRSFPIIGTRWIYWKFGSYKLNAVHLGFEAMFLCFGDIIREETLWNSPVISVINRDCIEKVLRQSGKYPIRPPNEVIANYRRSRPDRYTNTGVSNEQGVIWNSLRKRLTSKMTSPDVVQGVFPEIKSMVDDFIHLLCQARNKNNIVKGFEGLSNRMGLESSCMLILGRRNRFLDRVVNETAMRLTDAVTTQFRASQKTFYGHPFWKIIPTKLYKEFIASEETFYEIMSEIIDFALSDETQSGISENSVFGSILRAPNMDMKEKKAAIIEFIGAGIKTFGNTLVFVLYLIAKHPEVQEKLYNEISRLAPADTPITNEHLKQAKYLNACIMEAHRYSPTAPCIARVLESQIIYDGYCLPKGTTVLMQTGLACLDERNFKDATSYIPERWMNKETYDSLFLVAPFGCGKRICPGKKFVELALKIVLAKMVKQFHIGYEGQLETVFEFILTPVNANFILRDRIN*
Cyp315a1 Drosophila melanogaster
GenEMBL AC015141 229-2538 also AC008307 AC007725 AC007648
shadow sad gene
Cyp315a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
shadow sad gene
CYP315A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs1x1
Note: in Drosophila Cyp315a1 is the shadow gene (sad), a C2 hydroxylase
in the ecdysteroid biosynthetic pathway from cholesterol
Ortholog of shadow sad gene
CYP315A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroupUn.1189
38% to 315A1 Drosophila. Note this sequence is
named in the same subfamily as other CYP315s since
there seems to be only one orthologous sequence per
species and it does not make sense to name orthologs with
different subfamily names.
Ortholog of shadow sad gene
CYP315A1 Linepithema humile (argentine ant)
No accession number
CYP315A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
60% to CYP315A1 Linepithema humile
CYP315A1 Solenopsis invicta (fire ant)
See Solenopsis page
62% to CYP315A1 Linepithema humile
CYP315A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
68% to CYP315A1 Linepithema humile
CYP315A1 Bombyx mori (silkworm)
AB167737 BAAB01119643.1
Niwa,R., Matsuda,T., Yoshiyama,T., Namiki,T., Mita,K., Fujimoto,Y.
and Kataoka,H.
CYP306A1, a cytochrome P450 enzyme, is essential for ecdysteroid
biosynthesis in the prothoracic glands of Bombyx and Drosophila
J. Biol. Chem. (2004) In press
probable ortholog
See silkworm page for sequence
Ortholog of shadow sad gene
CYP315A1 Manduca sexta (tobacco hornworm)
GenEMBL DQ357068
Rewitz,K.F., Rybczynski,R., Warren,J.T. and Gilbert,L.I.
Identification, characterization and developmental expression of
Halloween genes encoding P450 enzymes mediating ecdysone
biosynthesis in the tobacco hornworm, Manduca sexta
Insect Biochem. Mol. Biol. 36 (3), 188-199 (2006)
MHRMTRLLSKQQKLLIFQRNAASAECIRTDLTINEMPHPKSMPI
LGTKLEFFAAGGGKKLHEYIDNRHKQLGSIFCENLGGSADLVFISDPTLMKTLFLNLE
GKYPAHILPDPWILYEKLYGSKRGLFFMNGEEWLNNRRIMNKHLLKEDSEKWLNDPVK
ATIKSFINNWKTRAEQGNFIPDLETEFYRLSTDVIIAILLGSNSSIKTSKQYEMLLCM
FSESVKNIFQTTTKLYALPVTWCQRINLKVWRDFKECVDMSLFLAHKIVTEILNRRHE
NDGLIKRLCEDKMSDEDIIRIVADFVIAAGDTTAYTSLWTLLLMAKNKDYVNNELPMK
DINNIKHVVKEAMRLYPVAPFLTRILPKESILGPYKLNEGTPVIASIYTSGRDINNFS
RPEEFLPYRWDRNDPRKKELMNHNPSASLPFALGSRSCIGKKIAMLQITELMSQIVKN
FHLECLNKTPVNILTSQVLVPDKNIDIQVSLYDSSKLNKNECWL
CYP315A1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP315A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970122
41% to 315A1 Drosophila
Ortholog of shadow sad gene
MLFRRVLAQLSTRPKSSLVSANTVLHFDEIPSPKGLPLVGTTLALIAHGSTPKLHDYVDKRHKQLGPIFK
EKLGPVSAVFVADPDEIRAVFDHEGKHPLHVLPDAWVAYNQMYGCPRGLFFMDGANWWYHRRIMNRLLLK
GDFRWIEGACECVSDKLIDSLMGESDYCGNLEATLYKWSLDVIVSILLGSGSYSQLCGELEPKVQKLAQV
THLVFQTSAKLALIPASFASKFKIPQWRRFVDSVDNALAQANALVDTLIEKKPHSDGLLPKLLAEQITLE
DIKRIIVDLVLAAGDTTAVAMEWMLYLVAKSPQIQEKLRRNPDFVKHVFKETLRLYPVAPFLTRILPEDA
ILGGYGVPKGTLVVMSIYTSGRDGRYFKNPGLFQPERWDRKDEFYSSEMKKASLPFAMGLRACVGRKVAE
TQLQMTLLKIVNKFEVELGNQREVEIVLKMVAVPSEPLLLKFKKL
CYP315A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Nov. 22, 2011
Complete seq. 49% to CYP315A1 Tribolium castaneum
CYP315A1v1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
50% to CYP315A1 Tribolium castaneum
CYP315A1v2 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
3 aa diffs and a 5 aa deletion compared
to CYP315A1v1 Dentroctonus ponderosae
CYP315A1 Aedes aegypti (yellow fever mosquito)
CYP315A1 Culex pipiens
CYP315A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP315A1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
68% to CYP315A1 Trialeurodes vaporariourum (whitefly)
CYP315A1 Acyrthosiphon pisum (pea aphid)
LOC100159616
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
sad 2-hydroxylase
mito clan
MANRYCSLVLVNSTKKRFMSTSNLKTVITESKKEIPIVKGLPLVGTMFSILAAGGGRKLHEYIDKRHQKYGSVFREKLGSVDAIWISNPLDMKLLFAQEGKFPKHILPEAWLLYNDTYGQKRGLYFMNGKEWWKYRQIFNKVMLKDLNVNFIKSYKVVINDLLNEWELSNGQVIPNLIADLYKISISFMVAHLVGRVYDDCKNDLSNDINCLAQCIQKVFQCTVKFTVIPAKTSKLLKLNIWNDFVIAVDNSIESANNLVSKLMSLNGDGLLNSVLNVHDIPIDMIKRLMIDFIIAAGDTTAYSTQWSLYTLGLHKSIQNNLRHSLLKTDFLECDYLNNILKEVLRMYPLAPFITRIPPSDIYLTDHKIPANSLVIMSMFTSSRNGKYFNSPNEFIPDRWNRLKNNKYNGVNEPFATLPYGFGARSCIGQKMAHVQMCLTLSE
CYP315A1 Trialeurodes vaporariourum (whitefly)
CYP315A1 Laodephgax striatellus (small brown planthopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee June 22, 2011
Clone name scaffold29888
39% to CYP315A1 Maduca sexta N-term
Missing C-term
top hits are all CYP315A1, presumed ortholog
note: species corrected from Sogatella frucifera
CYP315A1 Laodelphax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 6, 2011
Missing C-term
CYP315A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
40% to CYP315A1 Tribolium castaneum
CYP315A1a Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
N-term part 91% to CYP315A1 Laodelphax striatellus
CYP315A1b Sogatella frucifera (white-backed plant hopper)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
C-term part 40% to CYP315A1 Tribolium
CYP315A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP315A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP315A1 Daphnia pulex (water flea)
CYP315A1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
46% to CYP315A1 Aedes aegypti, top 14 hits are all CYP315A1
Cyp316a1 Drosophila melanogaster
GenEMBL AC017388 35538-37158 also AC010113 AC010557 AC010112
Cyp316a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
Cyp317a1 Drosophila melanogaster
GenEMBL AC020477 126550-128106 no introns also AC009844 AL109349
Cyp317a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP317A2 Lucilia cuprina (Australian blowfly)
No accession number
Zhenzhong Chen
Submitted to nomenclature committee Dec. 18, 2007
clone name Luce0114D11
47% identical to Dm Cyp317a1 probable ortholog
CYP317B1 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
49% to CYP317A2 Lucilia cuprina
45% to Cyp317a1 Drosophila melanogaster
clone name 2111
Cyp318a1 Drosophila melanogaster
GenEMBL AC014186 comp(968-207) AA803931 AA803220 AA821188 N-terminal
half
AC019897 comp(2937-4007) C-terminal half
Cyp318a1 Drosophila pseudoobscura
See D. pseudoobscura page on this server for sequence
Obtained from UC Santa Cruz Browser
CYP319A1 Boophilus microplus (cattle tick)
No accession number
Haiqi He
Submitted to nomenclature committee March 29, 2000
CYP319A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP319A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP319A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP319A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP319A5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP319A6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP319A7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP320A1 snail
No accession number
Anne Lockyer
C-terminal is 36% to 304a1 35% to rabbit 2E1
Submitted to nomenclature committee Aug. 29, 2000
CYP321A1 Helicoverpa zea (earworm)
No accession number
Masataka Sasabe, Xianchun Li, May Berenbaum, and Mary Schuler
Submitted to nomenclature committee June 15, 2001
Clone name X14
33% to CYP6B2
CYP321A1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee July 17, 2007
ortholog to H. zea 96%, 68% to 321A2
CYP321A2 Helicoverpa zea (corn earworm)
No accession
Xianchun Li
Submitted to nomenclature committee Oct. 3, 2005
clone name: 321DL6-4
67% to 321A1
CYP321A2 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee July 17, 2007
97% to 321A2 H. zea, probable ortholog, 67% to 321A1
CYP321A3 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee July 17, 2007
67% to 321A2 H. zea, 92% TO 321A1 H. armigera
CYP321A4 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee July 17, 2007
66% to 321A2 H. zea, 67% w/o this seq
95% to CYP321A1 H. armigera
CYP321A5 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH000216 100% to HAH013481 97% to CYP321A3, 94% to CYP321A1
This might be CYP321A3v2
CYP321A6 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_212 94% to HAH000216 N-term region,
probably not the same gene
97% to CYP321A3, This might be CYP321A3v3
CYP321A7 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Nov. 21, 2008
Clone name Sf321like-gp1
65% to CYP321A2, 67% to 321A5, 67% to 321A3
CYP321A8 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Nov. 21, 2008
Clone name Sf321like-a
66% to CYP321A2, 66% to 321A5, 66% to 321A1
CYP321A9 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Nov. 21, 2008
Clone name Sf321like-b
64% to CYP321A2, 81% to 321A7,
78% to CYP321A8, 67% to 321A1
CYP321A9 Spodoptera litura (a moth)
KC789752
Zihbin Xu, Sichun Zheng, Qili Feng
submitted to nomenclature committee April 19, 2011
96% to CYP321A9 Spodoptera frugiperda
CYP321A10 Spodoptera frugiperda (a moth)
KC789753
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
81% CYP321A9 Spodoptera frugiperda
CYP321A11 Spodoptera littoralis (cotton leafworm)
JX310085
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
88% to CYP321A9 Spodoptera frugiperda
CYP321A12 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
93% to CYP321A9 Spodoptera frugiperda
CYP321A13 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP321B1 Spodoptera litura (a moth)
GU263829.1
66% to CYP321B1 Helicoverpa armigera
CYP321B1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_148 49% to CYP321A1, 46% TO CYP321A2
HAH001868 4 aa diffs to Contig_148
CYP321B1 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
88% CYP321B1 Spodoptera litura
64% to CYP321B1 Helicoverpa armigera
presumed ortholog
CYP321C1 Amyelois transitella (Navel orangeworm)
No accession number
Guodong Niu
submitted to nomenclature committee May 27, 2008
clone AL34-1
53% to CYP321A1, less to the other CYP321As, 50% to CYP321B1
CYP321C2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
56% to CYP321C1 Amyelois transitella
CYP321D1 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP321E1 Plutella xylostella
Gene number CCG013958.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
48% to CYP321A8 Spodoptera frugiperda
CYP322A1 Perna canaliculus (New Zealand green lipped mussel)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
47% to 4F12 partial seq. from I-helix to heme
placement uncertain may be in the CYP4 family but
clusters outside the 4 family in some trees
CYP323A1 Saccostrea glomerata (Sydney rock oyster)
No accession number
Karl Herron
Submitted to nomenclature committee Oct. 9, 2001
41% to 4Y1 partial seq. from I-helix to heme
CYP324A1X Trichoplusia ni Family: Noctuidae (caterpillar)
Renamed CYP324A6
No accession number
Ping Wang
Submitted to nomenclature committee May 20, 2002
32% to 6K1 33% to 6G1 (sequence 3)
70% to CYP324A6 Helicoverpa armigera
67% to CYP324A6 Spodoptera littoralis
CYP324A1X Bombyx mori (silkworm)
Renamed CYP324A8
BAAB01098782.1 BAAB01016062.1
BAAB01088903.1 BAAB01068119.1 BAAB01136435.1
45% to 324A6 Trichoplusia ni
See silkworm page for sequence
CYP324A1X Heliconius melpomene (common postman butterfly)
Renamed CYP324A9
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
48% to CYP324A1 Helicoverpa armigera
CYP324A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_234 52% to CYP324A6 Trichoplusia ni
Contig_219 1 aa diff to Contig_234
CYP324A1 Helicoverpa armigera
No accession number
Rene Feyereisen
Submitted to nomenclature committee May 2, 2013
Scaffold 343-1.33
97% to CYP324A1 Helicoverpa armigera (from Heiko Vogel)
CYP324A1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
74% to CYP324A1 Helicoverpa armigera
CYP324A2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
51% to CYP324A1 Helicoverpa armigera
CYP324A3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
52% to CYP324A1 Helicoverpa armigera
CYP324A4 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
68% to CYP324A3 Heliconius melpomene
CYP324A5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
65% to CYP324A3 Heliconius melpomene
CYP324A6 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
67% to CYP324A1 Trichoplusia ni
CYP324A6 Trichoplusia ni Family: Noctuidae (caterpillar)
Formerly CYP324A1
No accession number
Ping Wang
Submitted to nomenclature committee May 20, 2002
32% to 6K1 33% to 6G1 (sequence 3)
70% to CYP324A6 Helicoverpa armigera
67% to CYP324A6 Spodoptera littoralis
CYP324A6 Helicoverpa armigera
No accession number
Rene Feyereisen
Submitted to nomenclature committee May 2, 2013
Scaffold 343-0.27a
73% to CYP324A6 Spodoptera littoralis (cotton leafworm)
70% to CYP324A6 Trichoplusia ni (probable ortholog)
CYP324A7 Helicoverpa armigera
No accession number
Rene Feyereisen
Submitted to nomenclature committee May 2, 2013
Scaffold 343-0.27a
92% to CYP324A1 Helicoverpa armigera (from Heiko Vogel)
93% to CYP324A1 H. armigera scaffold 343-1.33
CYP324A8 Bombyx mori (silkworm)
Formerly CYP324A1 but probably not an ortholog
BAAB01098782.1 BAAB01016062.1
BAAB01088903.1 BAAB01068119.1 BAAB01136435.1
52% to CYP324A1 Helicoverpa armigera
45% to CYP324A6 Trichoplusia ni
See silkworm page for sequence
CYP324A9 Heliconius melpomene (common postman butterfly)
Formerly CYP324A1 but probably not an ortholog
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
53% to CYP324A3 Heliconius melpomene
48% to CYP324A1 Helicoverpa armigera
CYP324A10 Amyelois transitella (navel orangeworm)
CYP324A11 Amyelois transitella (navel orangeworm)
CYP324A12 Chilo supressalis (striped rice stem borer)
CYP325A1 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
94% to 325A2
CYP325A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r14
CYP325A2 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
94% to 325A1
CYP325A2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r12
CYP325A3 Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
89% to 325A1
CYP325A3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r11
CYP325B1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r13
CYP325C1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r10
Formerly named CYP327A1
CYP325C2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r7
CYP325C3 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs3r3
CYP325D1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r9
CYP325D2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r6
CYP325E1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r5
CYP325E2P Aedes aegypti (yellow fever mosquito)
CYP325E3 Aedes aegypti (yellow fever mosquito)
CYP325E3 Culex pipiens
CYP325E4P Culex pipiens
CYP325F1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r3
Formerly named CYP326A1
CYP325F2 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r1
Formerly named CYP326A2
CYP325G1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPd2r2
CYP325G2 Aedes aegypti (yellow fever mosquito)
CYP325G3 Aedes aegypti (yellow fever mosquito)
CYP325G4 Culex pipiens
CYP325H1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2r2
CYP325J1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2r1
CYP325K1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2r4
CYP325K2 Aedes aegypti (yellow fever mosquito)
CYP325K3 Aedes aegypti (yellow fever mosquito)
CYP325K3v1 Culex pipiens
CYP325K3v2 Culex pipiens
CYP325L1v1 Aedes aegypti (yellow fever mosquito)
CYP325L1v2 Aedes aegypti (yellow fever mosquito)
CYP325L2 Culex pipiens
CYP325M1 Aedes aegypti (yellow fever mosquito)
CYP325M2 Aedes aegypti (yellow fever mosquito)
CYP325M3 Aedes aegypti (yellow fever mosquito)
CYP325M4 Aedes aegypti (yellow fever mosquito)
CYP325M5 Aedes aegypti (yellow fever mosquito)
CYP325N1 Aedes aegypti (yellow fever mosquito)
CYP325N2 Aedes aegypti (yellow fever mosquito)
CYP325N3v1 Culex pipiens
CYP325N3v2 Culex pipiens
CYP325P1 Aedes aegypti (yellow fever mosquito)
CYP325Q1 Aedes aegypti (yellow fever mosquito)
CYP325Q2 Aedes aegypti (yellow fever mosquito)
CYP325R1 Aedes aegypti (yellow fever mosquito)
CYP325S1 Aedes aegypti (yellow fever mosquito)
CYP325S2 Aedes aegypti (yellow fever mosquito)
CYP325S3 Aedes aegypti (yellow fever mosquito)
CYP325T1 Aedes aegypti (yellow fever mosquito)
CYP325T2 Aedes aegypti (yellow fever mosquito)
CYP325U1 Aedes aegypti (yellow fever mosquito)
CYP325V1 Aedes aegypti (yellow fever mosquito)
CYP325V2 Culex pipiens
CYP325V3 Culex pipiens
CYP325V4 Culex pipiens
CYP325V5v1 Culex pipiens
CYP325V5v2 Culex pipiens
CYP325W1 Aedes aegypti (yellow fever mosquito)
CYP325X1 Aedes aegypti (yellow fever mosquito)
CYP325X2 Aedes aegypti (yellow fever mosquito)
CYP325X3P Aedes aegypti (yellow fever mosquito)
CYP325X4 Aedes aegypti (yellow fever mosquito)
CYP325X5P Culex pipiens
CYP325X6 Culex pipiens
CYP325X7 Culex pipiens
CYP325X8P Culex pipiens
CYP325X9 Culex pipiens
CYP325Y1 Aedes aegypti (yellow fever mosquito)
CYP325Y2v1 Aedes aegypti (yellow fever mosquito)
CYP325Y2v2 Aedes aegypti (yellow fever mosquito)
CYP325Y3 Aedes aegypti (yellow fever mosquito)
CYP325Y4 Culex pipiens
CYP325Y5 Culex pipiens
CYP325Y6 Culex pipiens
CYP325Y7 Culex pipiens
CYP325Y8 Culex pipiens
CYP325Y9 Culex pipiens
CYP325Y10 Culex pipiens
CYP325Z1 Aedes aegypti (yellow fever mosquito)
CYP325Z2 Culex pipiens
CYP325Z2-de2b3b Culex pipiens
CYP325AA1 Aedes aegypti (yellow fever mosquito)
CYP325AA2 Culex pipiens
CYP325AB1 Culex pipiens
CYP325BB1 Culex pipiens
CYP325BB2 Culex pipiens
CYP325BC1 Culex pipiens
CYP325BC2 Culex pipiens
CYP325BD1 Culex pipiens
CYP325BE1 Culex pipiens
CYP325BF1v1 Culex pipiens
CYP325BF1v2 Culex pipiens
CYP325BF1-de1b Culex pipiens
CYP325BG1 Culex pipiens
CYP325BG2P Culex pipiens
CYP325BG3 Culex pipiens
CYP325BH1 Culex pipiens
CYP325BJ1 Culex pipiens
CYP325BK1 Culex pipiens
CYP325BK2 Culex pipiens
CYP325BL1 Culex pipiens
CYP325BM1 Culex pipiens
CYP325BN1 Culex pipiens
CYP326A1X Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
80% to 326A2
retired number renamed CYP325F1
CYP326A2X Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
80% to 326A1
retired number renamed CYP325F2
CYP327A1X Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
retired number renamed CYP325C1
CYP328A1X Anopheles gambiae (mosquito)
no accession number
Rene Feyereisen
submitted to nomenclature committee 7/5/02
low 30% range to all drosophila not CYP4, 6 or 9
retired number renamed CYP325H1
CYP329A1 Anopheles gambiae (malaria mosquito)
GenEMBL
Submitted by Christelle Abgrall, Hilary Ranson and Rene Feyereisen
See the paper: Evolution of supergene families associated with
insecticide resistance.
Ranson, H., Claudianos, C., Ortelli, F., Abgrall, C., Hemingway, J.
Sharakhova, M.V., Unger, M.F., Collins, F.H. and Feyereisen, R.
Science 298, 179-181 (2002)
Anopheles map name CYPs2r5
CYP329B1 Aedes aegypti (yellow fever mosquito)
CYP329B1 Culex pipiens
CYP330A1 Carcinus maenas (shore crab)
GenENMBL AY328466
Kim Rewitz
submitted to nomenclature committee 6/18/2003
37% to 2J2
CYP331A1 Capitella capitata (polychaete worm)
No accession number
Bo Li
submitted to nomenclature committee 2/3/2004
most similar to CYP5 and CYP3 sequences (low 30% range)
in the CYP3 clan
CYP332A1 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
3 aa diffs to HaCypZ004a-v2Pep CYP332A1v1 Helicoverpa armigera,
64% to 332A1 silkworm
CYP332A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_202 100% to CYP332A1 from Rene Feyereisen
Contig_203 1 aa diff to Contig_202
Contig_204 contains duplication, 1 aa diff to Contig_202,
2 aa diffs to Contig_203
HARM_contig_1 contains duplication
CYP332A1v1 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee 12/30/2003
33% to members of CYP6, in the CYP3 clan
505 aa seq #1 HaCypZ004a-v2Pep
CYP332A1v2 Helicoverpa armigera (cotton bollworm)
No accession number
David G. Heckel
submitted to nomenclature committee Feb. 21, 2005
HaCypZ004b-v2Pep
1 amino acid difference with CYP332A1v1
CYP332A1 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
77% to 332A1 H. armigera, 70% to 332A2 H. armigera,
64% to 332A1 Bombyx, probable ortholog
CYP332A1 Spodoptera frugiperda (the fall armyworm)
ESTs DV078358.1, FP381982.1
MFGFIIQLVLVFIISCLSVFYLLVRSNYGYWKKRGVPYEEPKFVFGNLSFLMRRSFWDVFYD
LSKKYKKHDYVGIFMSWKPALMLFSKDLSKKVLVKDTDSFQDRYSYSGMKDDPLGSLNLFSI
KSPMWVQMRNELSPMFTSLRLKGVTELMNINSTELVRRVQKDYIDQNKPVDLKELFSMYTSD
TVAYTVFGIRVSVLKELASPLWDITQHMVRWTFWRGLEFTLVFFLPAIAEVFRLKFFSQPAx
XxxxxxxxxxxxxxxxxxxxxxxxxVNHLLKLKANLKLPAGSDAELADNLMMAQVAVFILGS
IETSSTTLAYMLNELAYHPEEQEKLYEEVTAALKESGKEILQYDDLMNVKYLTACMHETLRK
YPPVAHLDRVCNKAYQLTENLTIEPGTPVYVNVVAIHHNEDYYPEPEEWKPERFINSTDSDN
HDFTFLPFGEGPRFCIGKRYGMMQIRTAIAQLITKYRFEPAAPKNLGTDPYSVLLAPKNGGK
VKFVPRT*
CYP332A1 Bombyx mori (silkworm)
ESTs CK502566 CK518690 CK526599 CK522682
BAAB01119140.1 BAAB01018054.1 BAAB01100160.1 BAAB01098663.1
BAAB01157576.1
64% to CYP332A1 probable ortholog
See silkworm page for sequence
CYP332A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
58% to CYP332A4 Manduca sexta
CYP332A1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
95% to CYP332A1 Heliothis virescens
CYP332A1 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
CYP332A1 Heliothis virescens (tobacco budworm)
85% to CYP332A1 Helicoverpa armigera
ESTs GT055981.1 GT129546.1
MFGAIIQLFLVFVISCLTVIYFFFRSNYGYWKKRGVPYEKPNPFFGNLLFLMRRSFW
DVFYDFSKKYKGGYFGIFLSWRPA
LMIHSKELAKKVLVKDSDSYQDRYAYSGADGDPLGSLNLFTLKSPMWVQMRHEVSPMFTSMRLRG
ITELMNINSSELVHRIQKDHIDNNAPVDLKELFSMYTSDTVAYTVFGIRVSALKELTSPL
WYITRHMVRWTFWRGLEFTMVFFLPAIAEFFRLQFFSQPATDYIKKLFEEVVAERQKTGQ
SSDKDLVNHLLKVKTSLKLPANSDSHLADNLMMAQAAVFILGAIETSSTTLTYMLHELAY
HPDEQEKLYEEVSAALKQSGKDVLEYDDLLKVKYLTACMHETLRKYPPVPHLDRICNKTN
KLTDELTVEAGTPVFVNLVAIHYDEDSYPEPEQWRPERFINSNDSDNHDFTFLPFGEGPR
FCIGKRYGMMQVRTAVAQMITKFRFEPDAPEILESDPYSVILSPKNGGKVKILPRS*
CYP332A1 Trichoplusia ni
EST FF376408.1
69% to CYP332A1 Helicoverpa armigera
HELSHHPEQQEKLYQEVSKALKESGKDILDYNELLELKYLTACIHETLRKYPPVQLLDRA
CNNTFKWKDLTIESGTPVYVNILGIHYDEEKYPQPDEWRPERFINSSDNDNHDFSFLPFG
EGPRFCIGKRYGMTQIRCALAQLITKYRFESDSEYKVVSDPYSVLLTPKYDTKTKIFARS*
CYP332A2 Helicoverpa armigera (Australian cotton bollworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 13, 2007
71% to CYP332A1v2 Helicoverpa armigera
58% TO 332A1 silkworm
CYP332A2 Helicoverpa armigera (Australian cotton bollworm)
FP340428.1 (BAC clone)
83473 MIATLIQLFLVFILSCLIVFYFFSRSNYGYWKDRGVPYDEPKLFFGSLSFLMRTSAWDVF 83294
83293 YCLSKKYKCDYFGIFLSWKPALVIHSKELAKKVIVKESDSYQDRYIASGVDDDPLGALNL 83114
83113 FTIK 83102
79939 SPMWMQMRHEITPTFTSMRLKNITEVMNINSTEVVNRIQKDHVDSNKPVDLK 79784
KLFSMYTSDTVAYNVFGIQVSSLKDLTS 79326
79325 PIFFITRYMMRWTFWRGLEFTMIFFLPAVAKLLR 79224
79075 LKLFSQTATEYTKKLYREVVAEREKSGQTGDKDLVSHLLKLNANSKLPAESGS 78917
78023 ELSENLMMAQAAFSILGSMETSSTTMSYVLHELAHHSDEQ 77904
77649 QEKLYEEVSEALKESGKDVLDYDDLLKVKYLTACIQ 77542
77270 ETLRMHPPVPHLDRMCNKKNQLTDELTVEAGTPVFVNVVAIHYNEEYFPEPEQWRPDRFS 77091
77090 NSTDTDNHDFTFIPFGDGPRFCI 77022
76641 GKRYGMMQIRAVIAQIIKKYRIEPDGPQTWQTDPYSVFLRPKHGGKVKFIPRS* 76480
CYP332A2 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
89% to CYP332A2 Helicoverpa armigera
CYP332A2 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
85% to CYP332A2 Helicoverpa armigera
CYP332A3 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-3
55% to CYP332A1 Bombyx mori
CYP332A4 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP332A5 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP332A6 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP333A1 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee 12/30/2003
38% to members of CYP12, in the mitochondrial clan
243 aa seq #6 HaCypZ009a-v2Pep
note: seq. Revised, 95% identical to older version
CYP333A1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_213 58% to CYP333A2, 45% to CYP333B2
Note: this sequence overlaps with Grubors seq by 10 aa
Together they form a complete P450 sequence
HAH003861 100% to Contig_213
HAH003861_2 100% to Contig_213
Contig_244 100% to HAH003861
CYP333A1 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
87% to CYP333A1 Helicoverpa armigera
CYP333A1 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
84% to CYP333A1 Helicoverpa armigera
CYP333A2 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP333A3 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP333A4 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
65% to CYP333A3 Manduca sexta
CYP333A5 Plutella xylostella
Gene number CCG007344.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
61% to CYP333A1 Heliothis virescens
missing the N-term 32 aa
CYP333A6 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
72% to CYP333A1 Heliothis virescens
CYP333A7 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP333B1 Bombyx mori
AADK01000081.1, AADK01010165.1, EST BJ985225.1
39% to 12B2 mito BAAB01158176.1 BAAB01035519.1
BAAB01083643.1 BAAB01120305.1 39% to 49A1 39% to 12F2
47% to CYP333A1 75% to combined (BAAB01158865.1 + BAAB01136746)
N-terminal is upstream of a repeat seq. I cannot identify it.
Bmb006234 from Li Bin
MIIALHYSKLRPVLNFSCLQQCVR ()
TVTVSAATEKLQQTELKSFREIPGPSSLPIMGPFLHFMP
GGSLHNINSTELTHKLYDIYGPIVRIDSMFSKDAIVLLYDAESAGI
ILRNENNMPIRISFKSLSYYRQKYKKSENDRTDRPTGLVSD ()
HGELWKSFRSAVNPVLLQPKTIRLYSSALEEVATDMVERL ()
RSLRDENNRIRGQFDQEMNLWSLESIGVVALGNRLNCFDSNLQDDSPVKRLIECVHQ
MFVLSNELDLKPSIG (1?)
QLNYTKNIFKTRLIYFSLTKYFIKKALDDIKMNKSKSDDEKPVLEKLLDINEEYAYIMASDMLVAGVDT (0)
TSNTMSATLYLMAINQDKQQKLREEVMSKNGKRSYLRACIKEAMRILPVV
SGNMRRTTKEYNILGYHIPEN ()
VDIAFAHQHLSMMEKYYPRPTEFIPERWLTNKSDPLYYGNAHPFANSPFGFGVRSCI ()
GRRIAELEVETFLSKIVENFQVEWSGSSPRVEQTSINYFKGPFNFIFKDL*
CYP333B2 Bombyx mori
BAAB01158865.1 AADK01000081.1 BAAB01179470 BAAB01136746.1
whole seq 61% to 333B1
MIGLYILFITFFFLFQNLIYCQ (1)
ATVSTSENVDVTNLKPFHEIPGPSSLPLIGPLLHFIPG (1)
GSLYTPDTKDFSAKLFKLYGPIVKLDPLFARNTLLMVYDPESAAN (0)
VLRSENRIPYRGGFNSLAYYRKHIKKHENNHKKLTGLITE ()
GEEWWDLRSTVNPVLLQPKTIKLYSAAIDEVAQEMMNR (2?)
MHRKLDENDRLQAKFDDEMNLWALESIGVVAFGIRLNCFDPNLAENSPEKKLIECVHQI
1459 FNLSNQLDFQPSLWHIFSTPTYKKAMKMFQLQEE 1358 ()
545 LSKYFINKAMRNINKNENKPDEQKGVLEKLLDINEEYAYIMATDMLVAGVDT 390 (0)
176 VANSIAATLYLFAKNPEKQEKLREEVMSKESKRYLKACIKETMRMMPVVSGNLRRTT
4119 KEYNILGYHVPKG 4081 (0)
3451 IDVAFAHQDLSSMEEHYPRPTEFIPERWLADKNDPLYYGKAHPFVMAPFGFGVRSCI 3281 ()
2571 GRRIAELEIETFLTKILENFRVEWYGPPPKIIQTSINYFTGPFNFVFNDIKKK* 2410
CYP333B3 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
50% to CYP333A1 C-term fragment from H. armigera,
85% to 333B3 H. armigera EST, 74% to CYP333B4,
CYP333B3 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
91% to CYP333B3 Spodoptera frugiperda (probable ortholog)
CYP333B3 Helicoverpa armigera (cotton bollworm)
EST E399501
85% to CYP333B3 Sf-41I04-Ekg, probable ortholog
82% to CYP333B4 Sf-41I04-Dkg
VVFAHRDMSLLDEHYxxxREYIPKRWLASKDDPLYYGNAHPFAHxx
FGFGARSCIGRRIAELEMDTFVARLIENFQVEWFGPPPTVQQAALNYIKGPYNFIFKDV*
CYP333B3 frag. Helicoverpa armigera (cotton bollworm)
Same as EST EE399501
Vladimir Grubor
submitted to nomenclature committee 12/30/2003
55% to CYP333A1, in the mitochondrial clan
92 aa, seq #15, HaCypZ015a-v1Pep
two frameshifts in EST shown below
CYP333B3 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH004245 77% to CYP333B1, 100% to CYP333B3
CYP333B3 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
93% to CYP333B3 Helicoverpa armigera
CYP333B4 Spodoptera frugiperda (the fall armyworm)
No accession number
Rene Feyereisen
submitted to nomenclature committee June 22, 2007
45% to CYP333A1, 82% to CYP333B3, 36% to Cyp12f2 Anopheles
CYP333B5 Plodia interpunctella (Indianmeal moth, Lepidoptera)
EB823285.1 cDNA clone N-term,
51% to CYP333B1
77 RNVAVNAATVNEEQDVKVEGRPWQEVPGPKSLPLIGQLYHFLPGGLFYKTTNQEFTRKAL 256
257 ELYGPIVRLNGMPGMPPMIMLFDPQCAEQVLRGENWLPHRPGFQSLEYFRHYYKN 421
422 NNTITNEPTGLVTDHGEPWKQFRSTVNPILLQPKTIKLYTSALEEVANDMIQRMXSIRGE 601
602 NNMLKSNLT 628
CYP333B6 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_182 53% to CYP333B1 mito clan, 54% to CYP333B4
HAH004275 100% to Contig_182
Contig_183 3 aa diffs to Contig_182
CYP333B7 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_280 95% to contig_182, 54% to CYP333B1 mito clan
CYP333B8 Zygaena filipendulae (zygaenid moth, Lepidoptera)
No accession number
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_4757
Mitochondrial, 56% to CYP333B2 Bombyx, 55% to 333B1 Bombyx
CYP333B9 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP333B10 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP333B11 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP333B12 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP333B13 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
65% to CYP333B11 Manduca sexta
CYP333B14 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
62% to CYP333B13 Heliconius melpomene
CYP333B15 Plutella xylostella
Gene number CCG007344.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
61% to CYP333A1 Heliothis virescens
CYP333B16 Plutella xylostella
Gene number CCG007339.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
60% to CCG007338.1 CYP333B15
CYP333B17 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP333B18 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP334A1 Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup9.6
34% to 12A5 Drosophila. In the mitochondrial clan
CYP334A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
62% to CYP334A1 Apis mellifera
CYP334A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
63% to CYP334A1 Apis mellifera
CYP334A1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP334B1 Tribolium castaneum (red flour beetle)
GenEMBL XP_971083, protein , AAJJ01000115.1 genomic
30% to 301A1 Drosophila, 30% to CYP301A1 Tribolium
42% to 334A1 bee
MSILRGKNSPFCILRRFNNLKNFAHDSTKTSATSASATQAPSPGTFTIS (1)
GKPSISVPQDTVKVTLQKPDMDVLVDTTTISRQMVAEQISKSIAFDNIPGPISLR
56932 IIHRIWGMVPILSTQITGGAIQYFLAV (1)
56799 GSLLSWSGN
MALFKRFFDHYGPVVRLHGPLGGDIVMVSRPEHIAAVFKNEGPYPIRSSLDSVEKYRLQHRKLRHTGPIL
MFGPEWENFRKSIEQPLPQLIARQYDKIDDACNKFIARIANIRNRQEEVPGTFQKEIYKWCLECMCLVTL
DKKLGFLDPCGLSSTSDPGVLLDGLMKATKAIQRCEYGLHLWQFLPTPAWKSLVENCDAIDNVLSKYVHR
IQVLIKEKKEASDGVSKEVNCLMENVLLKPGIMVEDAMTILLDMMLIGINATAHTIAFMLYHLAKNPRCQ
VKLYNEIARQPKKLSKDALAAMPYLQACIKETLRLKPPIPLLGRILNDDLSIYNYHIPRGTYLLMVTSLS
SWREEYFEDAHKFMPERWLTPIDDMQLFASIPFGYGAKACLGKELAEMQIGALITKILRNFKIEYLYGDI
NSTNKLWAAPNKKLRFRFAERV
CYP334C1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph334-2, 41% to 334B1 Tribolium, 41% to CYP334D1P
Pediculus genome site
CYP334D1P Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph334-1P, 34% to 334B1 Tribolium, 32% to 334A1 Apis, 41% to CYP334C1
Pediculus genome site
CYP334E1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
50% to CYP334B1 Tribolium castaneum
clone name DPO011_J18
CYP334E2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
50% to CYP334B1 Tribolium castaneum
clone name DPO021_D04
CYP334E3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 6
57% to CYP334E1 Dendroctonus ponderosae
N-term to PKG
CYP335A1X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7a
40% to Cyp9f2 Drosophila melanogaster. 50% to 9J8 partial seq.
63% to CYP9P2
renamed CYP9P1
CYP335A2X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7b
40% to CYP9K1 Drosophila melanogaster. 54% to 9J7 partial seq.
63% to CYP9P1
renamed CYP9P2
CYP335B1X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7c
39% to CYP9E 42% to 335A1
57% to CYP9Q2
renamed CYP9Q1
CYP335B2X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7d
57% to CYP9Q1
renamed CYP9Q2
CYP335B3X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7e
58% to CYP9Q2
renamed CYP9Q3
CYP335C1X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7f
44% to CYP9Q2
renamed CYP9R1
CYP335D1X Apis mellifera (honeybee)
WGS section genbank
Submitted by May Berenbaum 2/11/04
AmGroup14.7g
49% to CYP9R1
renamed CYP9S1
CYP336A1 Apis mellifera (honeybee)
WGS section genbank
EST BI946448
Submitted by May Berenbaum 2/11/04
AmGroup2.15
34% to CYP6AH1
CYP336A2P Linepithema humile (argentine ant)
No accession number
CYP336A3P Linepithema humile (argentine ant)
No accession number
CYP336A4 Linepithema humile (argentine ant)
No accession number
CYP336A5 Linepithema humile (argentine ant)
No accession number
CYP336A6 Linepithema humile (argentine ant)
No accession number
CYP336A7 Linepithema humile (argentine ant)
No accession number
CYP336A8 Linepithema humile (argentine ant)
No accession number
CYP336A9 Linepithema humile (argentine ant)
No accession number
CYP336A10P Linepithema humile (argentine ant)
No accession number
CYP336A11P Linepithema humile (argentine ant)
No accession number
CYP336A12P Linepithema humile (argentine ant)
No accession number
CYP336A13 Linepithema humile (argentine ant)
No accession number
CYP336A14P Linepithema humile (argentine ant)
No accession number
CYP336A15 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
68% to CYP336A8 Linepithema humile
CYP336A16 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
62% to CYP336A5 Linepithema humile
CYP336A17 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
63% to CYP336A4 Linepithema humile
CYP336A18P Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
61% to CYP336A4 Linepithema humile
CYP336A19 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
66% to CYP336A8 Linepithema humile
CYP336A20 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
60% to CYP336A5 Linepithema humile
CYP336A21 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
70% to CYP336A7 Linepithema humile
CYP336B1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP336C1 Nasonia vitripennis (jewel wasp)
See wasp page
CYP336D1 Nasonia vitripennis (jewel wasp)
See wasp page, formerly CYP336-un1
CYP337A1 Bombyx mori (silkworm)
BAAB01181176.1 BAAB01007828.1 BAAB01049389.1
60% to 337A2 29% TO 6A21 30% to 6P3 36% to CYP321A1
See silkworm page for sequence
CYP337A2 Bombyx mori (silkworm)
BAAB01100580.1 BAAB01137171.1 BP123442 EST
60% to 337A1 31% TO CYP6as 35% to CYP6AB1 37% to CYP321A1
See silkworm page for sequence
CYP337A3 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP337B1v1 Helicoverpa armigera (cotton bollworm)
No accession number
Vladimir Grubor
submitted to nomenclature committee Dec. 30, 2003
51% to 6P5 (58/113aa), C-term frag. 144 aa
seq #8 HaCypZ011a-v2Pep, also called CYP337B1-a
formerly CYP6AP1 54% (76/140aa) to 337A1 over a longer range
this partial sequence clusters with CYP337A1 and A2 on trees.
Note revised sequence 2/21/05 is complete 50% to 337A1
CYP337B1v2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_180 has 3 aa diffs to HAH000584 and 4 aa diffs to CYP337B1v1,
50% to CYP337A1 N-term
Contig_151 part of it has 2 aa diffs to Contig_180,
part = 100% to HAH011223
Contig_214 100% to Contig_151
CYP337B1v3 Helicoverpa armigera (cotton bollworm)
No accession number
David Heckel
submitted to nomenclature committee Oct. 25, 2011
CYP337B1-c
2 aa diffs to CYP337B1v2
CYP337B1v4 Helicoverpa armigera (cotton bollworm)
No accession number
David Heckel
submitted to nomenclature committee Oct. 25, 2011
CYP337B1-b
7 aa diffs to CYP337B1v1 and CYP337B1v3
CYP337B2v1 Helicoverpa armigera (cotton bollworm)
No accession number
David Heckel
submitted to nomenclature committee Oct. 25, 2011
seq. s3-a
2 aa diffs to CYP337B2v2, 6 aa diffs to CYP337B2v3
75% to CYP337B1v4
CYP337B2v2 Helicoverpa armigera (cotton bollworm)
No accession number
David Heckel
submitted to nomenclature committee Oct. 25, 2011
seq. s3-c
2 aa diffs to CYP337B2v1
CYP337B2v3 Helicoverpa armigera (cotton bollworm)
No accession number
David Heckel
submitted to nomenclature committee Oct. 25, 2011
seq. s3-b
5 aa diffs to CYP337B2v2
CYP337B3 Helicoverpa armigera (cotton bollworm)
No accession number
David Heckel
submitted to nomenclature committee Oct. 25, 2011
seq. s2, a natuarrly occuring hybrid seq between
CYP337B1 and CYP337B2
Aa 171-end has only 1 aa diff to CYP337B1v1
The fist 189 aa have only 1 aa diff to CYP337B2v3
CYP337B4 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP337C1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
51% to CYP337B1 Helicoverpa armigera
CYP337C2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
95% to CYP337C1 Heliconius melpomene
CYP337C3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
90% to CYP337C4 Heliconius melpomene
CYP337C4 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
90% to CYP337C3 Heliconius melpomene
CYP337C5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
83% to CYP337C1 Heliconius melpomene
CYP338A1 Bombyx mori (silkworm)
BAAB01074380.1
See silkworm page for sequence
CYP338A1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
60% to CYP338A1 Bombyx mori
renamed as the ortholog, formerly CYP338A2
CYP338A1 Amyelois transitella (navel orangeworm)
CYP338A1 Helicoverpa armigera (cotton bollworm)
CYP338A1 Chilo supressalis (striped rice stem borer)
CYP338B1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
45% to CYP338A1 Bombyx mori
CYP338C1 Plutella xylostella
Gene number CCG009572.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
49% to CYP338A1 Bombyx mori
37% to CYP338B1 Heliconius melpomene
CYP339A1 Bombyx mori (silkworm)
CK534983 CK537464 CK535691 BAAB01021114.1 31% to 301A1 anoph.
BAAB01141557 BAAB01170021.1 BAAB01154229
See silkworm page for sequence
CYP339A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
61% to CYP339A1 Bombyx mori
renamed as the ortholog, formerly CYP339A2
CYP339A1 Plutella xylostella
renamed as the ortholog, formerly CYP339A3
CYP340A1 Bombyx mori (silkworm)
Many seqs but chromosome order and assembly incomplete
See silkworm page for sequence
CYP340A1-de9b Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340A2 Bombyx mori (silkworm)
Many seqs but chromosome order and assembly incomplete
See silkworm page for sequence
CYP340A2-de9b Bombyx mori (silkworm)
nscaf2330 1296468-1296620 (-)
1296620 GKTYALISTKIILAHLVRRYKVTADISKIEFKMDVIMTPSDNCYVEFELRK 1296468
CYP340A3 Bombyx mori (silkworm)
Many seqs but chromosome order and assembly incomplete
See silkworm page for sequence
CYP340A4 Bombyx mori (silkworm)
Many seqs but chromosome order and assembly incomplete
See silkworm page for sequence
CYP340A5P Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340A6 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340B1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340C1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340D1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340E1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340F1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP340G1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_181 44% to CYP340A3, 42% to CYP340A4, 44% to CYP340D1,
29% to CYP4L5
HAH015944 100% to Contig_181
CYP340H1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH012927 40% to CYP340A4, 32% to CYP4V2 danio
Contig_250 100% to HAH012927
Contig_222 after aa 52 is 100% to Contig_250
The first 52 aa is only 72% to Contig_250
(hybrid or alternative splice?)
CYP340H2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH010140 56% to CYP340H1, 36% TO CYP340A2, 28% to CYP4G11
CYP340J1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH001912 40% to CYP340H1, 38% to HAH010140,
36% TO CYP340A3, 29% to CYP4L5
CYP340K1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_189 this one has the correct C-term 44% to CYP340G1,
42% to CYP340F1, 36% to CYP340A4, 28% to CYP4M6, 30% to CYP4V2
HAH015382 100% to Contig_189 except at the ends
(retained intron in HAH015382?)
CYP340K2 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
72% to CYP340K1 Helicoverpa armigera
CYP340K3 Heliothis virescens (tobacco budworm)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
72% to CYP340K1 Helicoverpa armigera
CYP340K4 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
52% to CYP340K1 Helicoverpa armigera
CYP340L1 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Nov. 21, 2008
44% to CYP340H1, 41% to CYP340A4
40% to CYP340J1 (N-term half), 38% to CYP340A2,
CYP340M1 Bombyx mori (silkworm)
No acession number
See silkworm page for details, formerly CYP340-un1
CYP340N1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
42% to CYP340G1 Helicoverpa armigera
CYP340P1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
43% to CYP340C1 Bombyx mori
CYP340Q1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
47% to CYP340D1 Bombyx mori
CYP340Q2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
77% to CYP340Q1 Heliconius melpomene
CYP340R1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
49% to CYP340D1 Bombyx mori
CYP340R2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
87% to CYP340R4 Heliconius melpomene
CYP340R3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
90% to CYP340R4 Heliconius melpomene
CYP340R4 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
87% to CYP340R2 Heliconius melpomene
CYP340R5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
81% to CYP340R4 Heliconius melpomene
CYP340S1v1 Plutella xylostella
Gene number CCG002082.2a
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
46% to CCG010920.1
43% to CYP340C1 Bombyx mori
missing the C-term (see CCG002082.2b last line for a similar seq)
CYP340S1v2 Plutella xylostella
Gene number CCG013063.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
99% to CCG002082.2
48% to CCG010920.1
49% to CCG008537.1
46% to CYP340C1 Bombyx mori
missing N-term
CYP340T1 Plutella xylostella
Gene number CCG002082.2b
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
42% to CYP340C1 Bombyx mori
CYP340U1v1 Plutella xylostella
Gene number CCG007213.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
44% to CCG010920.1
CYP340U1v2 Plutella xylostella
Gene number CCG008532.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
99% to CCG007213.1
CYP340V1v1 Plutella xylostella
Gene number CCG000924.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
40% to CYP340C1
missing the N-term 82 aa
CYP340V1v2 Plutella xylostella
Gene number CCG002776.1b
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Second gene C-term half
97% to CYP340V1v1
CYP340V2 Plutella xylostella
Gene number CCG002776.1a
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
Adjacent to CCG002776.1b
CYP340W1v1 Plutella xylostella
Gene number CCG008537.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
45% TO CCG010920.1
43% to CYP340C1 Bombyx mori
CYP340W1v2 Plutella xylostella
Gene number CCG004867.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
98% to CCG008537.1
42% to CYP340C1 Bombyx mori
CYP340X1 Plutella xylostella
Gene number CCG006839.1a
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
48% to CCG002082.2
41% to CYP340C1
CYP340X1-frag1 Plutella xylostella
Gene number CCG006839.1b
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
100% TO CCG006839.1a, 92% (3 DIFFS) TO CCG006839.1C
58% to CYP340G1 Helicoverpa armigera
CYP340X1-frag2 Plutella xylostella
Gene number CCG006839.1c
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
55% to CCG002083.1
53% to CYP340A3 Bombyx mori
CYP340Y1 Plutella xylostella
Gene number CCG002083.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
42% to CYP340C1
CYP340Z1 Plutella xylostella
Gene number CCG010920.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
41% to CYP340D1 Bombyx mori
missing N-term 24 aa
CYP340AA1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
49% to CYP340H1 Helicoverpa armigera
CYP340AB1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
49% to CYP340L1 Spodoptera frugiperda
CYP340AC1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP340AD1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP340AE1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP341A1 Bombyx mori (silkworm)
BAAB01068196.1 BAAB01181661.1 BAAB01053162.1
BAAB01098630.1 BAAB01068157.1 BAAB01166031.1 BAAB01162916.1
39% to 4C3
See silkworm page for sequence
CYP341A2 Papilio xuthus (swallowtail butterfly)
No accesion number
Hajime Ono
Submitted to nomenclature committee Jan. 4, 2005
61% to 341A1
CYP341A3 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341A4 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341A5 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341A6 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341A6-ie5b Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341A7X Bombyx mori (silkworm)
No acession number
See silkworm page for details
Seems to be a chimera, not a true gene
CYP341A8 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
74% to CYP341A3 Bombyx mori
CYP341A9 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
86% to CYP341A10 Heliconius melpomene
CYP341A10 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
86% to CYP341A9 Heliconius melpomene
CYP341A11 Spodoptera frugiperda (a moth)
No accession number
Rene Feyereisen
Submitted to nomenclature committee Aug. 1, 2011
70% CYP341A1 Bombyx mori
CYP341A12 Plutella xylostella
Gene number CCG013707.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
69% to CYP341A1 Bombyx mori
CYP341A13 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
87% to CYP341A11 Spodoptera frugiperda
CYP341B1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341B2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH001776 56% TO CYP341B1, 44% to CYP341A3 Bombyx,
32% to CYP4L5, 33% to CYP325G3
CYP341B3 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
73% to CYP341B2 Helicoverpa armigera
CYP341B4 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP341C1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP341D1 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
HAH014764 48% TO CYP341C1, 47% TO CYP341B1, 31% to CYP325G1
CYP341E1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
52% to CYP341B1 Bombyx mori
CYP341E2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
60% to CYP341E1 Heliconius melpomene
CYP341E3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
CYP341F1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
43% to CYP341B1 Bombyx mori
CYP341G1 Plutella xylostella
Gene number CCG000631.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
46% to CYP341B1 Bombyx mori
missing the N-term 55 aa
CYP341H1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP341-un1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP342A1 Nereis virens (annelid polychaete worm, clamworm, sandworm)
GenEMBL AY453408.1 (partial seq)
Rewitz KF, Kjellerup C, Jorgensen A, Petersen C, Andersen O.
Identification of two Nereis virens (Annelida: Polychaeta)
cytochromes P450 and induction by xenobiotics.
Comp Biochem Physiol C Toxicol Pharmacol. 138, 89-96 2004.
Clone name CYP4(2), CYP42 in abstract
Submitted to nomenclature committee April 29, 2005 (full seq)
Only 35% to CYP4BB1 from the same worm
34% to Cyp4f14 mouse
CYP343A1 Apis mellifera
MWFVILCFVIVLIKILFDYSRPINFPP (1)
GPRGLPFIGNILDIIKLINETKYYSDTWCRLAEKYGSVVGLRLGLDQPLIIVSGKSAVTEM
LNRSEFDGRPSGFLYKYRCGGMQQGILFTDTDVWHSQRR (2)
FALKTLKQFGFGKNSMEHILQHDAIALTNIIIELTKDGTVKNIRSIISAAVLSNLWLLIDGTK (2)
FDIGMENSNLKEAINIVQDIVKSSNVSGGIINQFPFLRHLFPNLTGFSAFVERQKRINNFFM (0)
EVIAKHKWKKINEEGTNFIDVYLQEIQKKNSSHSFFN (1)
ENQLLYIIKDLFSAGVDTTNSTIGFIIAFLVVHQDVQSKVYDEISRVIDKDIYPSLSDKDR (2)
LPYLKAVIAEVSRLANIGPTSIPHRAVKDSTFLGFEIKKNYTLLANFKSIHMDKEHWGDPE
IFRPERFINEKGDFINDSWLMPFGL (1)
GRRKCLGETLAKNTVFLFVACMLQRLHFMLPSNHPPPCLQGIDGFVIAPPMMDIIAVQRF*
CYP343A1 Linepithema humile (argentine ant)
No accession number
CYP343A1 Atta cephalotes (leafcutter ant)
See Atta cephalotes page
58% to CYP343A1 Apis mellifera
CYP343A1 Solenopsis invicta (fire ant)
See Solenopsis page
83% to CYP343A1 Pogonomyrmex barbatus
CYP343A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
57% to CYP343A1 Apis mellifera
CYP344A1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CO741715
David Drane
2clan 32% to 18A1
N-term only
MLSLVNCAIITALVSVLYFLFKKRNHNGIYGLPPGPSGWPIVGSLGTLF
GVQRHQKLASDGRKYGGIFTMHIGAVHSVWITSFKIFREAVVDNTWAFAG
CYP345A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970561, protein, AAJJ01001436 genomic
88% to CYP345A2 Tribolium, CYP3 clan
10779 MLLTSYLPLDTFLLLSVFTLLLYKYFSRNYDHWEKKNVFFFKPTPFFGNILDISLFRTTIGEHLAKLYNQ
TTEPFFGIFVFDKPHLIIKSPELVKTILVRDFNNFDDRGVASPHHDPLVKNMLFFNKNPEWKNVRVKMTP
VFTTGKLKGMIPLINDIGETLTKYIAQKTSNLSLEAKEISAKYTTDVIAKCAFGINANSLKNEDAEFRNL
GRRFFDFRWSNAIQQTSYFLLPGLVNVLKLRVMDKKDSNFLRETFWQTIKLRQENNSKAKDLIDAIIAMK
ENKEFCKNFNF 9907
9862 EGDKVVAQAAQFFIAGFETTSATMAFTLYELCLQPQIQSKVRTEIMTCVKEHNGLTYEA
LQDMKYLNMCVC (1) 9650
9600 ETLRKYPVLPFLDRTCKEDYKLPNSNVVIEKGTPVFIPMFGLHYDPQYFPNPQKYDPE
RFSDENMQNITPFSYIPFGEGPRNCI 9349
9299 GERFGLISTKLGLIHVLSNFEVERSSDTPVPLEFEPKSFVLASK
VGLPMKFKKVMTSAA* 9120
CYP345A2 Tribolium castaneum (red flour beetle)
GenEMBL XP_970633, protein,
AAJJ01001436 exon 1 only
AAJJ01003559 exons 2-4
88% to CYP345A1 Tribolium, CYP3 clan
4485 MLLTPYLPLDTVVLLSVLALLLYKYFSRNFDHWEKKNVFYFKPIPFFGNFVDISLFRTTIGEHLAKLYNQ
TTEPFFGIFVFDKPHLIIKSPELVKTILVRDFNNFDDRCIASPHHDPLVKNMLFLNKNPEWKNVRVKMTP
VFTTGKLKGMIPLINDVGETMTKYIAQKIPNFSLEAKEICAKFSTDVIAKCAFGINANSFKNEDAEFRKI
GRRIFDFRWSTAIQQTSYFFLPGLVNLLKFRMLDKDASDFLRETFWHTIKLREEKNLKANDLIDAIIALK
DNQEFCKNMNF 3613
EGDKVVAQAAQFFVAGFETTSSTMAFTLYELCLQPQFQRRVRAEIATCLKEHNGLTYEA
LQSMKYLNMCVCETLRKYPVLPFLDRTCKEDYKLPNSNVVIEKGTPVFIPMFGLHYDPQYFPNPQKYDPE
RFSDENMQNITPFSYIPFGEGPRNCIGERFGLIGTKLGLIHILSEFEVEKSSDTPVPLEFEPKSFVLASK
VGLPMKFKKVMTSAA
CYP345B1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970485, protein, AAJJ01001436 genomic
45% to CYP345A2 Tribolium, CYP3 clan
MGLELQFSIINLLILLITFWTTLYLYFTRKFNHWKSKNVPQVAPIPFFGNAFEVFTWRKNIGEFARQIYN
STTKPFIGFFICDEPYLLIRDPELVKSILVKDFAVFSNRSISENKENDPMGSHLLFLLKTPDWRDMRRKI
TPVFTSGKMKNMYSLISEAGNDMIQHMRKEVSKSDQLEMREVAARYTTDAITSTSFGINANCFKNEKAEF
REVSRRVFNWAIWERSISTTCYFIAPNLVKLFKLKFIDSASATFLREAFWRTMTDREEKKFVRNDLLDIL
IDIKKQEDINDPYKL
16321 DGDKLVAQATQFFVAGFETTSSTICFTLYELAINKDLQNKLKSEIRDVVRKHGEI
SYNSLKDMEYLDMCIK (1)
ETLRKYPVLPFLDRKCDTDYRIPGSDVVLEKGSPVFISVSGLHYDPQYFPDPDK
YDPLRFTEENIKSRPQFTYLPFGEGPRNCI (1)
GARFGSVSSKSGVAKIISEFEVDLCEKTQHPIQIDPKGFLMAPVSDLVLKFKRLDD 15592
CYP345C1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970418
46% to CYP345B1 Tribolium, CYP3 clan
MMFVIFFAVLFLIYYYLTRNFKHWEKKNVPFIKPLPFFGSI
YDGVLMRHSIGEVFYDLYYKSTKPFVGFFILDKPCLLIRDPKLIKKILVNDFQYFYDRNAVNNKRDDPIS
THILFILKNPDWRELRTKMTPVFTSSKIKIMSELIENASHEMTNYLNNHIKDYNSVEMRDVCLKFTVDVI
GSTIFGVQANSFKDENSQFSSVAKRLIDWDDIVTAFRFRCYLLAPLFVNLFRMKLFPPDCVNFLKNTFLD
IMDKRSVSNKSRNDLIDILLQMKNDNRNFIEGDILVSQALMFFVAGFETTSSTMGFALYEFARNPDIQDK
IRNEIKDISDKYGDIKYDSLKEMEYLDMCVKEVLRKYPVVPFLDRKCNTTYTIPDTNVTIDKDTPIFIPS
LALHYDPQYFPNADIFDPERFSSNNKTGIDSFAYLPFGEGPRNCIGARFGLLTAKLGLVHILKEFVVSCN
EKSNEKIKFNPKGMVLSALNGINLKLSKVEKAT
CYP345D1 Tribolium castaneum (red flour beetle)
GenEMBL XP_966774
63% to CYP345D2 Tribolium, CYP3 clan
MFLVYFASFLLLLYYIYAKNYNYWQSRNVPTDKPFLFFGSFYNIAVRKEHIFERIRTIYNQFSAPYVGIY
IFHQPVLLIRSPEILRKVLVKDFDKFTNRNIATNEAVDPLAFHTLFISKDAVWRNLRAKLSPVFTSGKMK
LMFPLMQECVDDLHRFLAQNTDEIDVKITMKKYSVDIISTCAFGINTFCFRNDNSEILKMATQLVDFKSV
VRSISIFSFFFMPSFVDIFRLTFADKTASDYLLNVFKTTLQEREKKKIIRNDFIDLLNNLRKTETITDGY
KFDNDIKMAAQAIAFFSAGNDTTSITLALTCYELALNKTIQDRLRHEVTEIYNESEAFTYENIARMKYLD
MVLNETLRKYPLAPFLNRKSDVKYTFEETGFTLDKGVSIIVPISGLHYDPEYYPDPEKYDPERFSDENKK
NLTPYTYLPFGEGPRNCIGQRFALLVSKVALASIIKDFAFDATNRTPVPLRFDPGSLFVQNRGGLYLKVS
KVAA
CYP345D2 Tribolium castaneum (red flour beetle)
GenEMBL XP_969536
63% to CYP345D1 Tribolium, CYP3 clan
MIFVYLCCFLLFLYYLYRKNYKYWESKGVLTEKPFFIFGSFYDVALRRKHLFHKVREIYDKFSTPYVGIY
IFNQPTLVIRSPELLKKVLVKDFDKFINRKVAANESVDPVFFHTLFSAKNDNWRNLRAKISPVFTSGKIK
LMFPLMKECGTDLLNYFKKRSGGVIEARNVTKKYAVDIISSCAFGINSYCLKDDNSEIMQIATQLVDFKS
FIRSISIFCFFFMPKLVDIFRLTFADKKASEYLMNVFKTTINERRKKTIVRNDLIDMLHNLKENSSSSDF
TFDDVKMAAQALSFFSAGNDTTSITITFALYELALNTDIQNRLREEIRKRYEAHGDFTYEAIQEMKYLEM
VLCETLRKYPLTIFLNREAVSNYTLEESGLTIDKGTSIMIPVAGLHFDEEYFPNPEKFDPERFSDENKSK
IVPYTYMPFGDGPRICIGQRFAMLVSKVALAYILKDFAVEKTDSTTVPMQLDPGAIFLMNKNGVNLRVVEVK
CYP345D3 Tribolium castaneum (red flour beetle)
no accession number
Jiang Hongbo
submitted to nomenclature committee June 19, 2007
91% to CYP345D1
CYP345E1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
84% to DPO043_F01, 49% to CYP345A2
42% to CYP6AT1 Cyp6Pd (antennae-rich 507aa Walter Leal scarab beetle
clone name DPO012_M11
CYP345E2 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
84% to DPO012_M11, 50% to CYP345A2
43% to CYP6AT1 Cyp6Pd (antennae-rich 507aa Walter Leal scarab beetle
clone name DPO043_F01
CYP345E3 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
84% to CYP345E2 Dendroctonus ponderosae
CYP345F1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
42% to CYP345D1 Tribolium castaneum
40% to CYP345A1
clone name DPO1126_E15
CYP345F2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP3 clan
Clone name seq 9
59% to CYP345F1 Dendroctonus ponderosae
N-term
CYP345F3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
62% to CYP345F1 Dendroctonus ponderosae
partial seq.
CYP345G1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP345G2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
83% to CYP345G1 Leptinotarsa decemlineata
partial seq.
CYP345H1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
47% to CYP345A2 Tribolium
nearly complete seq.
CYP345H2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
64% to CYP345H1 Leptinotarsa decemlineata
partial seq.
CYP345J1 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
53% to CYP345E2 Dendroctonus ponderosae
CYP345 fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-14
51% to CYP345F1 I-helix region
44% to CYP6AQ1 Apis mellifera (aa 255-346)
too short to name yet.
These two fragments might be from CYP345F2
CYP345 fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-10
66% to CYP345A2 Tribolium castaneum
65% to CYP345E1 Dendroctonus ponderosae
too short to name yet.
These two fragments might be from CYP345F2
CYP346A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_967901
63% to CYP346A2 Tribolium, CYP3 clan
MFLFDLQVSVIQLLSLFGVSILSGYYFYYRYCYTYWKKKGVPTSKPRFPFGDLSSSAWGKQSVYSRLETL
YHQFKAKGYKHAGIYFFNGPIYFPIDPDLVKRVLVTDFEYFVDRGMYGNGDELPLSCHIFSMKGEEWKNI
RTKMSPSFTAGKMKSIYNIVVHNCENLVKVFQPLAETRTVIDIKDILMRFTADVIGSTSFGIDCNSLDHP
DTEFSRMVNRISNHSGWKLLRVALEEGLQNPGNIEKIAYNDKVVEDFFTNLVKETMEYRDKNNIIRNDFL
HMLMQLRESAGMSLKEIVSQSFLFFIAGFKTSALTMCYCIHELAHSQDLQDKVREEIHKNLGRDVSKYAY
EELIALPTLDKVVKETMRKYPPLPMLNRICVKSYQVPGTDVVIDKDTPVIIPVLGLQRDPEFYPEPLKFD
PERFSNDNNIVPYTYLPFGDGPRNCIGLRFGMVKTKLAVAALLNNFRFLASSKTRRNLAIDPSTTSILFN
VSEGIYTKIIKV
CYP346A2 Tribolium castaneum (red flour beetle)
GenEMBL XP_968966
63% to CYP346A1 Tribolium, CYP3 clan
MLLLTAIELSSVFIISLLFAYYLYYRYCFTYWKKRGAPQLTPTFPVGDLSTAAWGKESVYLRLQTLYHKF
KDAGHKFGGIYFLNGPIYFPVHPDLIKRLLVTDFEHFVDRGMYIDEEKLPLTAHIFSMKGEQWKNVRMKF
TPTFTSGKMKSMYNILVQVSQHLIKTLDPVAEQGLEVDIKELLMRYTTDIIGSTAFGVDCNSLDNPNTEF
NRMVAMIFNNPSWKLYKMALEEGLQNPGNIIKIAHDNKVVQKYFNDLVRDTIEYRDKNNIVRDDFMNILM
QMRSTGMEFKEIVAQAFLFFTAGFETSSSTMSNCIHELAHNQEIQDKLREEIHENLGRESSKYTYDDVLA
LPYLDKCVKETLRKYPPVAMLNRICVKPYKIPDTETVVEVNTPVIVSVLGLHRDPEYFPEPLEFDPERFS
NSNKIAPFTYLPFGDGPRNCIGLRFGLMQTKLGLATLLNDFKFYPSPKSPRHLAVDPSTTTLVFSVLNGV
HTKIVKV
CYP346B1 Tribolium castaneum (red flour beetle)
GenEMBL XP_968751
77% to CYP346B3 Tribolium, CYP3 clan
MFKFDVFNTGVFELVCLFISLSIVSWYLYYIHCFNYWKKKQVPTHPPQFPAGNILKPVLGRENLFISVEN
YYKEFKRKGYKHAGLYFLNGPVYLPIDPEIVKSILTTDFDHFIDRGVFVDEQNFPLSAHLFSIKGSKWRS
LRTKLSPTFSSGKLKTMYEIFMKMTQNFIETLEPKAGRKEDINIKYIAANFTADIIFSTAFGLEGNTLQY
PDSKLGNLAKNLFNPSTWIVIKSLALEGLQNPGSILRAFISNKSIEEFFVDLVKKTVKHRDENKVVRKDF
LSLLLEIRDREGLSFNEIVAQCFLFFLAGFETSSQTISYTIHSLAYNQDVQDKLRKEIVDNLGSDFTKYT
YDDVLKLPYLDKVFNETLRLYPVLGFLNRICVKPYKVPGTDVVLDVGTPVLISTLGLQRDPEYFPNPFKF
DPERFSEDNSQVPFTFMPFGEGPRFCIGMRYGKLQTKLGIASLVSQFRFKPSPETPEFIEFDKFSKSLAM
SPVKGITVKIEKL
CYP346B2 Tribolium castaneum (red flour beetle)
GenEMBL XP_968823
86% to CYP346B1 Tribolium, CYP3 clan
MFVLLCLVISLSLVSWYLYYVHCFNYWKKKQVPTHPPTFPTGNILKSVLGKENIFITIENYYKEFKRKGH
KHAGLYFFNGPVYLPIDPEIVKSIMTTDFEHFVDRGVFVDEKNFPLSAHLFSIKGSKWRNLRTKLSPTFS
SGKLKTMYEIFMKMTQNFIETLEPKAGRKEDINIKYIAANFTADIIFSTAFGLEGNTLQNPDSKLGNVVQ
NLFNPSTWIVIKSLALEGLKNPGGIVRAFISDKALEEFFVNLVKNTVKHRDENKIVRNDFLSLLLEIRDK
EGLSFNEIVAQCFLFFLAGYDTSAQTISYCIHSLAYNEDIQDKLRKEILDNLGSDYTKYTYDNVLKLPYL
EQVLNETLRLYPVLGFFNRICVKPYKVPGTNVVLDVGTPVLIPTLGLQRDPEYFPDPLKFDPDRFRKDNS
LVPFTFMPFGEGPRFCIGMRYGKLQTKLGVASLLSQFKFKPSPETPELIKPENFSKSLSLVPVKGVTVKIEKL
CYP346B3 Tribolium castaneum (red flour beetle)
GenEMBL XP_968894
73% to CYP346B2 Tribolium, CYP3 clan
MFKFDMNNTTVFELLCTFITISLLSWYLYYGYCFNYWKKKGVPTTPPKFPAGNILKPVLGKENLFVTVED
YYREFKREGHKHAGLYFFNGPVYLPIDPEIVKSILTTDFDHFVDRGVFYDEQNFPLSTHLFSMRGTEWKS
LRMKLSPTFTSGKLKTMYEIFIKMTENFINVVKPKAETGEEINIKYTSANFTSDIIFNAAFGMEGHTLEN
PDNELSKVVLNVFNPSNWLFFKSILIEGLQNPGSLLRVVLSNKSMEKFFMDLVRTTVTHRDENKIVRKDF
LSLLLEIRDKEGLSFNEIAAQSFLFFLAGAETSSQTISYCIHQLAYHQDLQDKLRKEILDNLGTDFTKYT
YDDIFKLPYLDKVFNETLRLYPVLGFLNRICVKPYKVPGTNVVIDKGTPVLISLLGLQRDPEYFPEPLKF
DPERFSEGLEQVPFTFLPFGDGPRFCIGMRYGKLQTKLGIAALISQFRFLPSPKTPKFVEYDRPSKSLAM
VPAKGIIVKVEKL
CYP347A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970992, AAJJ01005243.1
36% to CYP6BQ11, 35% to Cyp28d1
gene model too long, shortened at C-term
MLPIVLFILACTICYFFVKINHAYWKKRGVVGPKPSFLVGNLGKSFILKSSPGEIYTEIYRKYKDASVVG
LFRSETPVLLVRDPELLKEITTKSFQHFRNNDIDVDKKHDPLFGRNPFVLKGDEWKTVRAQLTPGFTSGK
MKWLYSYLETNSKKMVEYILRVPEATNGQGYEAKELCIRYTLNNVGDAVFGIEGKCFEEKNSEFRKLSKE
FLSPGSYGIIIMFLATLFPPITKIFPMRFVTKSVEKKLTNLVSDALKHRQVNNIVRNDFLHIISQLKKTN
QDFTDVDVTAHAAGFFADGSETSSIVMSFVLFQLSINPDVQSKLRAEVTEAFNNNNNNMPYEVVQDLPYL
EAVIQETLRIQPPIHSLQKLCTKSFTWTLKETNKPLVIEEGTPIIIPTHALQSDPQHFEDPESFQPERFL
GENRENIKKCTHMPFGEGPRACL (1) 3393
3443 GQRFGLLQIKVGLAYIVKNFELSLNKKTKLPLKYDPINPLVTPTGGLWIDFKKIEKKKCNQIKSFH 3640
VMYLVIFPNIL*
CYP347A2 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01002940
57% to CYP347A1
4106 MIPIILTITVVTIVYYLLHLNYQYWKKRGIANPKPVFLLGNFGKCFFLRASPGQVYYDVYN (2) 4288
4341 KYKNEQVVGLYRATTPVLLVRDPELIKEVMVKSFSSFHNNDVYVYKKRDPIVGRNP 4508
4509 FVLKGEEWKSVRQQLTPGFTSGK (0) 4577
5532 MKWLYPLLDEVAENLVKFIENQPKTLNAKDVCARFTLNNVASCAFGIEGK 5681
5682 CFEEENNHFRQMAIEFLSPSSWSFIGLFLVLLNPSLLKVLPIKFVTKNCEKKLIDLVQQT 5861
5862 VKYREDNNVVRNDFLHILTQLKKTSSEFTDIDVVAHAAGFFGDGYETTAGVMSFVLYCLA 6041
6042 ENLDIQTKLRELVDKVFENNEEKLPYEALQEIHFLDAVVN (1) 6161
6216 ETLRLHPPALHFQKLCTQDFTFVLKNANKSVTIEKGTPVILPVYGLHHDPDYY 6374
6375 ESPDLFKPERFLPENKDKTVKCTFMPFGEGPRSCL (1) 6479
6527 GQRFGLLQVKVGVAHIIRHFELSVNGKTQRPIKYEPTNPVTAPVGGFWVNFRKIR* 6694
CYP347A3 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01002940, AAJJ01006489
62% to CYP347A2
9930 MLPIILIVTAVTIICYLIHLNYQYWKKRGVKGPRPHYLVGNIGKVLLLQASPGQVFAEAYN (2) 10112
10166 EFKDEDVVGLYRAMSPIILIRDPELVKEVILKSFNSFHDNDMYIDKGTDAIAGRHPFLLR 10345
10346 GDDWKITRQKLTPGFTSGK (0) 10402
403 MKWLYPLLEEVSATLIKFIETHPETTNGTGCDIKDLCGRFTLNNVASCAFGIEGKCLEEK 582
583 NSQFQQLALDFMSPGSTAFFTFFLSTIIPSLSKILKVRFISQDVENRLVDLIGQTVKYRQ 762
763 ENNVLRNDFLHILIELTKTHKDYQLIDVTSHAAAFFADGYETSASVMSFVLYELAANPGV 942
943 QERLREEVGEAFAKNGTLPYDGLQEIHFLDAIVSETLRLHPPLQHLQKVCTKDFTFVAK 1119
1120 NTNKTVTIEKGTTTIIPIYGLQHDSKFFENPDSFQPERFLGSNKDSIAKGTFLPYGDGPR 1299
1300 ACL (1)
GIRFGLLQIKVGVAYIIHHYELTVNKKTKVPLKFVATSPVTAPVGGFWLNFRKLK* 1521
CYP347A4 Tribolium castaneum (red flour beetle)
GenEMBL AAJJ01003892, DT790783.1 DT800167.1 = ESTs
59% to CYP347A1
4005 MLVILIILAIGVAFYFLKLNYQYWKKRGIPGPKPNFLVGNMGRSFILKASPGEIFAEAYQ (2) 3826
HKYNESEIV 3747
3746 GMYRATTPVLVVRDPDLVKEVTIKSFDHFSENDYEVDKRHDPIFARNPFVLKGEEWRTVR 3567
3566 AQLTPGFTSGK (0)
MKWLYPYLEKISENLVKFIETQINTNCEVKE 3387
3386 ICRRFTLNNVATCAFGLEGKCLEEENSEFRQLAKDFFTPPSSFFLMTVSPTLSKALAAG (2) 3210
1627 FIKKTIVSKFVDMVTQTLKYREENNIVRNDYLHVVSQLKKNSNNYKFTDIDVTAHAAGF 1451
1450 FGEGYETSSILMSFVLFEIAQNPHVQNKLREEINKAFEENGTLPYEVLQSLPYLDGVVN (1) 1274
ETLRIHPPMFSLQKICTKNFTYTSKNGNQVTIEAGTPIILPVY 1097
1096 GLHHDPKYYPDPETFKPERFMGENREKLTKYTFLPFGEGPRICL (1) 965
914 GKRFGVLQIKVGLAYIIRNFELSVNGRTILPIRYDPINIMTAPVGGLWIDFRKIEI* 744
CYP347B1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
42% to CYP347A2 Tribolium castaneum
clone name DPO0817_H01
CYP347C1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-6
50% to CYP347A1 Tribolium castaneum, 41% to CYP347B1
CYP347C fragment Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
92% to CYP347C1
CYP347D1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
41% to CYP347B1 Dendroctonus ponderosae
CYP347E1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
51% to CYP347B1 Dendroctonus ponderosae
CYP348A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_967784, AAJJ01002935.1
73% to CYP346B2 Tribolium, CYP3 clan
weak match to other P450s, new family, short
missing some large seq blocks in the mid region,
No Cys at heme signature,
no I-helix, probable pseudogene or non-functional as a P450
10591 MEQDWFFYSVTLFTFAVIFTFCYIRHVYTFFERKRIPRAGHPTFPFGNLYDVFFEKVPIFMQLWKFYNRF
KRKKCKLGGFYLFLKPAIVLVDTTLVQLFFTDVFAKDERDDLDANFCGQVLASVVKSVEKVWPKLGPFAE
NEANFTQILGQELVGLCAREFFDSNDAKLCEVEGSRVFPLFRKCVSLSYPQFCKNENHRFRGKNFEKAAK
NGVLQVLQKNGFSAKDRVDFIAELVDYLGKSSNLILFTLYELSLNREIQDDLRGEILRFRRNKDTFTYTE
LEQLTYLETVIC (1) 11466
11514 ETLRKYPMKPFVHKVCQKTFEQNGIKFDTNQTVFLSIFGIHHDVDNYINPELFDPDRF
SEENEMFIDPIKYLPFGHQIKNDF (1) 11760
11838 DSLYAKLIMKMILIELLSKYEFALGKKSPKCITFDENLFEIKSREDMWLKIKKL 11999
CYP349A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_973153
60% to CYP349A2 Tribolium, CYP4 clan
MFLLLVFLSLCFIWCLQFHWKRFRLYKLSRKIPGPLNLPLIGCAHLFFTGNAAEIAKRFMQMFDDYPDLA
KAWMGPELYYLITKPEYLEVVLNHNATLEKMDLYKFIRPIVGDGLISSP VKVWKRHRKIIAPTFNQKVLN
EFPGVICEQVNFLIELLRKECDKGEIDHCRYVTNCAIDIVGETIFGVSIGAQTGGKSYSLIFDKWMEVVF
MRIFRLDYQFEWIFSWTKASKIQEEVKRIIHTMTRDIIEKKKEQIGCQLEADDEKKKPFLNLLVEKHLNN
ELTLQELEDEVNTFLLAGSDTNATSGSFILTLLGMHQDVQDKLYEEVSKILGPERPPTLDDLPKLKYTER
VIKESLRVFPGAPFVARVVEEDVNLGDVIVPKGANIGLGYLHLHRSEKYWKEPLKFDPDRFLPENSINRH
PYTWLPFSGGSRNCIGWKYGMMVMKIMTAMVIRKFRVKSSIKSIGDIELTANVVLKPKNGFRLAFEMR
CYP349A2 Tribolium castaneum (red flour beetle)
GenEMBL XP_973195
AAJJ01007805.1 (1302-549), POSSIBLE AT BOUNDARY INSTEAD OF AG AT SETI
AAJJ01008257.1 (293-855)
AAJJ01008667.1(517-1079)
68% to CYP349A1 Tribolium, CYP4 clan
1302 (1) VKIWKKHRRIIVPTLNQSILNTFPQIICQQCDILLEILEK
KCDKGEIDHYKFVTNFAVDVV (1) 1120
1073 SETIFGVPLNAQITDANYSRTFDKIMEVVFMRIFRVDYHS
DFLFSWTKEYKAEQENVKLVKETTRDLIERKKEQITCQLEVE (1)
EEKKRPFLDVLVGKYLNEELSYQELEDEVSTFLLA (0) 675
617 GSDTNATAGCFVLTLLGMHQDVQ 549
293 EKLYEEIIEVLGPEKYPTLDDLPKLKYTERVIKETLRLFPGAPFIARIASDDID
LGDYVIPRGSNIAVGYVHLHRSEKYWEEPLKFNPERFLPENVAKRHPYTWLPFSGGLRNCV (1) 637
697 GGKFGMMVMKIMISMIIRKFRVKSSVKSVGDIELTANIVLKPKNGFRLAFTLR 855
CYP349A3P Tribolium castaneum (red flour beetle)
GenEMBL XP_968399
AAJJ01001569.1 pseudogene
Tribolium, CYP4 clan
KCDKGEIDHYKFVTNFAVDVV 15027
15074 SETIFEVPLNGQITNANYSRTFDKIMEVVFMRIFRVDYHS 15193
15192 LFSWTKEYKAEQENVKLVKETTRDLIERKKEQITCQLEVE (1)
15360 EEKKRPFLDVLVEKYLNEELSYQELEDEVNTFLLA
VIFCNVF
GSDTNATAGCFVLTLLGMHQDVQ 15554
16828 DKHYEEIIKVIGPEKSPTLDDLPKL
CYP349B1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
42% to CYP349A1 Tribolium castaneum
44% to CYP4CA1 Nasonia (might be missnamed, may be CYP349 seq)
clone name DPO0710_J17
CYP349B2 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
85% to CYP349B1 Dendroctonus ponderosae
CYP349C1X Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
53% to CYP349A1 I-helix to heme
renamed CYP412A1v3, 95% to CYP412A1v1
CYP350A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_968884
40% to CYP350C1
deleted small intron after LCS
MYFVTPGLIFTVIALWLLWSFLWKNFFATKIKGPWAFPLIGSAYVLFGGTHNILENTVRVVSKYRPLCKL
WLGNKLTIFPSNPDDIQMILNRSLEKEEGYRYIKTVFGHGLFTSPVSEWKGHRKVIVSTLNQQVLNSFMD
TYNIYTRELIEKLKIDTKDGQHIDMFPIMTQCTLDIICSSIMGTQMNAMKEESQFIMWMTRVAELAIIRM
FNIYLWPELFWKLSPISKESHELDQKIYNYVKTVIHNKRHKGLKSHTGKKIFLDYLVELTDREGRWTDEE
LTNETRSVIMAGSDATALTLSYCLVMLAMFQDIQDKVYEELCS
YLDRFIKET
LRVFPVTSMIGRELTTDMTIDGHFIPKGTSIGFPILYIHRNPEYYPDPLKFDPDRFLPEEVAKRHPCTFI
PFSFGPRNCIGYRYAMMTMKVILATLLRSFKMVHTPYKEISELKIKFDIATKVDEGYPVRMELRKNVAAGTK
CYP350B1 Tribolium castaneum (red flour beetle)
GenEMBL XP_968812, AAJJ01000155.1
42% to CYP350A1
CYP350A1 is also on this contig
MSISLLFYVFVCFLLILLWQKKRLLYYSWNIDGPLSIPLFGNPFVIFGGKY (1)
YVLNNMSLYSRKYKPICKFWVLGQLI
FWVSHPKYVEIILNKCLEKERSYKYLEVVLGRGLFTIP (1)
ANKWKKRRQVIESILDDDLIDSFAQIFKDYSDILLKKLGKFEGQYVDVMPIMTQFSLDIMF (1)
STILGTKVNALDEDTKIVIGVKD (2)
LIESIIKRLSNIMLRPNLFWKLLYLSQKSEELDRRIDHYFRTVLFQQK (2)
CKSTTGGKVFLDFLLNQTDENWTDDELLAETRTLIIAGTDAIATATSFCLVMLAMHPEIQ (0)
63877 DRLYNETGTAYLECVIKETLRLFPTYSFIGRELDEDVVL (1)
63717 GRYTLPKGSSVVVPLLDVQRSQKYWPQALEFKPDRFLPPKRGYFPFSVGPRNCL (1)
GREFALKAMKILLSNLLRTFQITETPFKSISDIKVSTNVVTRSFQGCMIKLQPR* 63346
CYP350C1 Tribolium castaneum (red flour beetle)
GenEMBL XP_967642
40% to CYP350A1
MQSTTILVALSAFTAFIYFLAEYFSKKQRLLRFHAAKLQGPPALPLIGSAYYLFGSNKSIVNNVIHLVKK
YKSPWKIWLGRQLYIVVTEPEDIEVVLNKALEKAENYNFLACLLQEGLFTGPVEKWKRHRKVILSTFSMP
ILKSFVEIFSENSLRMLPKLDKFVGKGTFDVCPILTNTALEITCETAMGTKIYEQAHSDYAYNLSKALEL
VFMRMFQYWLHPNFIWSLSIYSKQLKQLSKQLEIFVQGIVTEKKVQYRDKKHDLCLETKRRKCFIDHLIE
MSEDDNWHDHELLEEAQTMVAAGSESLGSVKSFTLIMLGMHPLIQDKVYNEMYNIFGPSDRTVTPDDLTE
MTYLDMVIKETLRLFPVTAAVGRRVSQDIVTDRYTLPEGCECIVSILSAHRNPKIWPKPLDFNPDRFLPE
EVAKRHPYSYLPFSNGPRNCIGFKYAMMAIKTVISTIVRRYKISTEFKSVPEIEFSPGVVLKSRKGYRTQ
LESRC
CYP350D1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jianhua Zhang
Submitted to nomenclature committee April 2, 2006
Clone name P341A2407
63 amino acids from heme to end
48% to 4C34, 44% to 4c3, 42% to 341A2, 52% to CYP350C1
CYP350D2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-8
69% to CYP350D1 Leptinotarsa decemlineata (Colorado potato beetle)
C-terminal
82% to CYP350D3 P-4-7
CYP350D3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-7
65% to CYP350A1 Tribolium castaneum
56% to CYP349B1
82% to CYP350D2 P-4-8
CYP350D3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
CYP4 clan
Clone name seq 19
100% to CYP350D3 Leptinotarsa decemlineata
CYP350D4 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
CYP351A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_973429, AAJJ01001080.1
59% to CYP351A8
MKPEKITSALIWVLFIIVLYFLLKYNWSRRWLYYYGSKIDGPFAWPIIGSAHHFIGGQKVFYKKMTQIFE
TYPTLSKFWLGKDLIVITSRPEDVEIVLNSCFEKPKFYKYAYKLFRTGLLIAPVNIWKERRRMIGPTFNS
4548 KTLQTFTEIFGKQANRLVRVLEQECGREFDIFLKLFRCTLDTAC (1)
EALVGVDSSLLQGQDNYLQKLIR (2)
AEDIATIRSFSPWLQ 4192
VDFFWKKSPLGREMDKACAESFTFIKQILSLKKCDFKDTTNPFTNYLQHLNKSNDDSPVEDEIQNILITG
SESSALALALVLVVLGIYPEVQQKIALELDSIFGDDEREPTFEHINQMEYLECVIKETLRILPIVPIIMR
LAEQDIKLEHCTIPAGSTVLVPIVHISKKSEFWKEPNKFNPDRFLPKNNSERHRCTFLPFSYGPRNCV (1)
GFKYGLMSMKVILATVLRKFTIKPTRYQSLEDIELIYGAVAKPKHGHKIKLEKKY*
CYP351A2 Tribolium castaneum (red flour beetle)
GenEMBL XP_973464, AAJJ01001080.1
60% to CYP351A8
MNFETINTTSALTWALLFIVLFFIIKYNWNRRWLYYYGSKIDGPFAWPIIGIAHYFIGGQKVFYNQLTKL
FEAQPPIFKFWLGQDLVVATSRLKDVEIILNNCFEKPKFYNFMCEVTGNGLLTARENIWKERRKMINQAF
SLKVLHSYVDIFSKRAKCLISWFEEDFGKEDVFFKLYRCTFDTAC (1)
7113 EALADVDPTLLHGKNNYINNLKR (2)
MIDILTIRSFSIWLHDDFFWKLSPLSKEMSKASAETFSFIKQ (0)
IIGLKKLDPKNHTSKRFLNHLLTLNETNPKFDDSAIEE
ELQTILITSSESTALTVGMIL
TVLGIYPEIQ (0)
6561 KKVSKELDSIFGHDDRETTLEDVQKMKYLECVIKETSRVLPAVPLLARLADKDIKLDNYT
IPAGSIIVIPIWQIGKNADFWKNPKKFDPDRFLPENCDPNRPRSSFIPFSYGPRNCIGFQYSNMLVKVLT
ATILRKYTIKCPQYTSFEQVEIIFSITARPKHGFKIQMEKKL
CYP351A3 Tribolium castaneum (red flour beetle)
GenEMBL XP_973499
84% to CYP351A4
MIEKIDLTSVFLTLFLAFIIKYNWDRRWLYYYGSKIDGPLGWPIFGSAHYLMGGHK (1)
VFYKNVNMLLKSYPSEVAKIWVGPTLLVSITKPEDVEIVLNKCLERPKFYEFGKEIVGSG ILTAP (1)
IDVWKSRRKMINPTFNPNILNSFVEIFGRHAFYLTNALEENCGKDSFDILPKLFRCTFDTAC
ETFGDVDSTLLHGRDEIFQNLTK (2)
AEDLVKTRGFTVWLHFEFFWNMTSLCKEYNQACNLLISIVKQ (0)
IIQLKKPSY (1)
NNNHREKRLLNHLLKLSKINAK
IDQTALEDEIQTILLTGSETTALTVGLTLIILGIYPEIQKKIGKELDVIFGKDDRVPTLEDINRMEYLER
VIKETLRFLTPVPFMLRTNNQDITLDSNTIPAGSCIMIPIFHIHKKPEYWKNPNEFDPDRFLPENSSKRP
RCAFIPFSSGPRNCIGFKYGMMSVKVLLAVILRKYTVVATEYKKVEDIEMLFYVVNKPISGCKIKLEKK
CYP351A4 Tribolium castaneum (red flour beetle)
GenEMBL XP_973531
84% to CYP351A3
MFDFIFVSLTLILAFIIKYNWDRRWLYYYGSKLDSPIGWPIIGSAHYIIGGHK (1)
VFYKNVNMLLKSYPSEVAKIWIGPTLVVSITKPEYVEIVLNKCLERPEFYEFGKQIIG
AGILTAP (1)
IDVWKSRRKMINPTFNPNILNSFVEIFGRYAFHLTNALEENCGKESFDILPKLFKCTFETAC (1)
ETLGDVNSNVLQGPEEIFENLTK (2)
AEDLITTRAFSLWLYLDFFWNMTSFCRELDKASKSIISIAKQ (0)
VIQIKKSSRNQKPSEPMIQ (1)
DNTYKEKRFVNHLLKLSETNAKLDQTALADEIQTFLLAGSETTALTVGLTLIILGIYPEIQKKIGKE
LEVIFGKDARVPTLEDINRMEYLERVIKETLRFLTPVPFMLRTNNQDITLDSNTIPAGSCIMIPIFHIHK
KPEYWKNPNEFDPDRFLPENSSKRPRCAFIPFSSGPRNCIGFKYGMMSVKVLLAVILRKYTVVATEYKKV
EDIEMLFYLVNKPISGCKIKLEKK
CYP351A5 Tribolium castaneum (red flour beetle)
GenEMBL XP_973568 + XP_973599
56% to CYP351A8
MICENVLVWLFSTLIA
FLLLNAWHKRRLLYYASKINGPFSWPIIGSAHYFIGGQK
VFYKKITQLLETQPEIFKIWLGGQLVVVTSRPEDVE VIVNKFFEKGPIVEYSKKFLGNSLLRAP (1)
AHIWKDRRKMLNPTFNQKILNTFMGTFATHAHKLVKELEEHCGKDYDVFSNLIRCTLNLAI (1)
ENLADVDSDLIQGQDNYLQNVKR (2)
LEDLLAIRIFTFWFHADFFWKMSPLSREMHKATEETFAFVKQVI (0)
IIKTKKMNVKQDNNSPTKGKLFINHLIKVSKTDAKIDDLAIEEEIQNILIASSETTALTAGLVLTILGIFPEIQFK
VSNELGAVFGHDGRAPSLEDINKMEYLECVIKETLRLFPVLPIILRFLDQDIKLGAYTIPAGCSIAIPIC
HLNKKADFWENPEKFDPDRFLRMNSSERHRCTFIPFSYGPRNCIGLKYGMMSLKVLLSTILRNYTIKPSV
YEKLEDIEMVFCVLSKPSLGFKVKLEKKM
CYP351A6 Tribolium castaneum (red flour beetle)
GenEMBL XP_973634
66% to CYP351A5
MFSNATSVLLYTFLTLILFLVLKNFWKKRRLYYYGSKISGPFSWPIIGSAHLFFSGPK (1)
VFYKTLVHFVETQPEIFKFWLGQHLLVVTSRPEDVDCVVNKFFEKGPFFEFGKQLLGDGL
LRAPAHIWKDRRKMFNPTFRTKILNTFIGTFGRHANKLVVELEECCGKQSCDLLFKLLRCSLDTAC (1)
ETLTDVDSTLLEGKNYLRNMIRC (1)
EDIVSVRTLSFWYHVDIFWKMSPLSREMDKGCEELFSFIKQ (0)
VIELKKLNRSQNNRDKDNAIKEKLFINHLLNLSETDRKIDDRVVEEEIQNILLTST
ETSTLGVGMVLIILGILPKIQGKVSEELKTIFGTDDRQPTLEDINKLEYLERVIKETFRLFPVVPMFIRS
ADHDIKFDCYTIPAGSIILIPIFQLNKKPEFWNEPQKFDPDRFLPENNSNRHRCTFIPFSYGPRNCLGLK
YGMMSMKVVLSTVLRNYTIKPTVYKKLDDIEMIFGIVNKPSLGFKVKLEKKCNFEI
CYP351A7 Tribolium castaneum (red flour beetle)
GenEMBL XP_973664 AAJJ01001080.1
73% to CYP351A8
MKRDYIDITCALTWAFSALALVFIIKYNWSRRWLYYYGSKISGPFAWPIIGSAHHFIGGQKVFYKNMIKL
FETQPPIFKFWLGKDLIVVTSRPEDVETVLSNCFGKPKFYDYSYKLFRDGLLIAPAKIWKDRRKIINPTF
NPRILNSFLDIFNKHANRVVDVFAEGCGKESFDVFLKLFRCTLDIACETLADVDSDLIKGQDAYLQKAIR
MEDVLAIRSFSVWLHPDIVWNNSSFGKEVAKASPEVFGFIKQIIGLKKLNPVPEDEFCKKKRFVNHLLTA
SETNPHFDELAVEEETQTILITGSETTAITIGMVLIILGIYPEIQEKIMDELDLVLGPDDRTITLEDINK
MEYLERVIKETLRVLPIVPIILRSVDEDIKLDPYTIPAGSFVLVPIGHIGKKPEFWKEANKFDPDRFLPE
NNSNRHRCTFIPFSYGARNCV (1)
GFKYGMMSMKVLLAAILRKYNVKPAQYKSLEEIELIFGMVTKPKHGFKIKLEKKTKKIVNV*
CYP351A8 Tribolium castaneum (red flour beetle)
GenEMBL XP_973698
73% to CYP351A7
MQPDIDVTSALTWAISALALFFLVKYNWKRRWLYYHGSKIDGPFGWPIIGSAHYFIGGQKVFYQKMVKVF
ETQPSVFKFWLGKDLLVVTSKPEDVEIVLNNNSCFGKPKFYDFAFKLFRNGLLIAPASIWRDRRRVINPT
FNPKILNSFIEIFGKHGNKLVKVLEESCSESDIFLKLFRCTFDIACETLADVDSELIKGQDKYLQTVIRM
EDILAIRSFSIWLHPDFLWKRSFYGKEMEKASAEVFAFVKQILALKKASVTDDENYKKKRFLNHLLTTSE
TNPQIDELAILEEIQTILVTGSETTAITIGMVFIILGIYPEIQEKVRSELELILGPDDREITLEDINNLE
YLERVIKETLRVLPIVPLITRTVEQDVKLGTKTIPSGSFVLVPIASIGKKAEFWAEPKKFDPDRFLPENN
ANRPRCSFIPFSYGPRNCIGFKYGMMSLKVLLATVIRKFTFKPSQYRRIEDVRLIYGMVAKPKHGFKVKI
ERIKT
CYP351B1 Tribolium castaneum (red flour beetle)
GenEMBL XP_973400, AAJJ01004605.1
first exon on AAJJ01001080.1
MKKTEFTITTILSLVILVLVFFFFIKYHWNRRWLYYHA
MKLPGPWALPILGSAHLFHGGYD (1)
DMYQAMLRLTKSQPPLFKIWLGQDLIFVTSRPEDCEIILSKCFTKGK
FATFMDPIFWEGLLTAPAIKWKSHRKIINPSFNIQILNSFIGVFNKHSKKLVEKMRKHAGSDSVDVSYWL
FRNTIDISCETLMDIDADLIKGQEEYIDDCIKAEKYSSTRMIGVWYHPEFIWKHSPLGKLTKATSDKILD
FVRKIIKLKKLEPEPLLKNCGDFPDDSMRKKHFLNNLLKMSENMTDDDILEETQTMLVAASETTALTMAT
VLLTLAIFPQVQEKIYEELDAILWNTDEITLEHINKMVYLEAVIKETMRILPTVPFINRRMTEDLHLNDC
VVPTGSNIIISIKNIHDSPLLWENPDKFDPERFLTERDPNRSRCAFMPFGYGPRNCIGFKFAMLSMKVMM
ASLLKNFTFEPAVYKSIAEIECFYNIVAKPKKGYKVKFSERKLYNNNDKL
CYP351C1 Tribolium castaneum (red flour beetle)
GenEMBL XP_969850, AAJJ01003994.1
43% to CYP351A8
MODEL TOO LONG REVISED
MFVVSAFLVGIVVLLLLRKRVTLWYYSAKLPGPFGLPFLGSLHLLVKGPKEIHQTLANIYKSYPKVVKIW
FGPWLYVSTTEPSDLKVILTHHLDKGEFYELMSEYFRRALAAAPVDLWKKHRKNINPTFNTTILNTFIGA
FAKQAEILVKNLEKYQSDEDIFPIVWKCTLDSACETLADVDPIFIDTEACLRRVFRIEEILLERFFNPLC
HLNILWKFSPLRKELAVLWKQNSTFITQMIDIMKQSDNLDKKRFLNHLIPSHDLNYTIEEAQIMFFVGTE
TSGVAISSVLLILGMFPQIQEKIFIEIDQVFGSTTGSTLDEINHLDYLERVIKETLRLLPPIPFVMRSLD
ENLKLSCGTFPAGSRVIVPIMMVHRREDFWPEPLKFDPDRFLEERPSGTYIPFSYGTRNCL (1)
5448 GYKYAMLSMKVILATILRKYRVKSSNYKSIDEVVLLIHIIAKATNGYKIVLEKRNK*
CYP351D1 Tribolium castaneum (red flour beetle)
GenEMBL XP_969258 AAJJ01003014.1
44% to CYP351A7
MGARFSFDLKCVLLYISVLLLLVFLLKYVWNKRFLYYYGSKISGPFALPLIGSAYYFTGGAK (1)
VLYDKLWQICEKYQPLAKIWLGPHLMVIPSHPKDVEYLLHNFVSKGQLYEYITPLFGHGLLTGT (1)
VEKWKDHRKLINASFNSKILNSFIDIFVTHAKSSLDVFKE
FCGKGQVDILPVFLRINIDGIC (1)
ETAMGVKPGTLSDRYDYLDWMMR (2)
AEHLIMVRMFRPWLYPDFIWKNTNMGKEQKQLCKKSWKFIANV
QKRGEKINTLHNDLKKLSFLEYFIDLTDEQQKWCEKELIEEAQT
1535 MVFTGSGSLAITECYVLLMLAIHPEIQEKIYEELLTIFGNSDRDLCFKDLSKLCYLDRVIKETLRLFPIA
PYIARLLDSDIHM () 1287
1173 EKYVIPKGTFALIPITYLQRNSNLWSEPLRFDPDRFLPEQVATRERCVYLPFSYGSRNCI (1) 996
GLKYAEISLKATLATILRKYKVTSCIYKSVEEIEFEFTMFIKPTRGSFVQIEERIR*
CYP352A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_970947, AAJJ01003994.1
35% to CYP9G14
MLFLLLVILIICCLVKYHWDRRKLYLFAAKLQGPKAYPVVGNGPLFWCKNEEIFNNFMAATAPYPSPVRL
WVGPKLVLFVKDPNQLQLILQSSKITTKSFLYRFLEPFLGKGLFTSSGPRQKHHRKLLQPLFSQRMIEGY
CHLFQKHSKKFVEDLRKNANGPEFNISTFLQFTAFEATMDLLLEDQDTHSIDYNEIPNYVRKFYEIVFTR
VKSFWLHLDIFFKLSSYYREQTKLQSLATTVINEITETNVPKIIEKIKAERKLADAEIRVPSMLESIAEM
VMENPDCLTMQDCTDHLMTFMATSQDTQSSAVAFTCMMLGAYPHIQDLVVQELREVMGKKTSLDLTDVSQ
LKYLEMCLKESMRLFPVGPFIFRDTTEDFQFDKMVIPEGVTVILSIYHAHRSPEHWEKPDEFYPEHFAPE
AMSKRHPCAFIPFSAGPRRCIAQHYSYTYMKILLATIVLNYEIECRFKAEDVKLIADISIRPQQGYLIKL
KDRTN
CYP352A2 Tribolium castaneum (red flour beetle)
GenEMBL XP_970893, AAJJ01004849.1
63% to CYP352A1
runs off the end of the contig
5530 MSEVLSNKTCVTLDELSKLNYLDMCLKESMRLFPVAPFIFRDTTEEFQLENLTIPGNVTLALSIYHAHRD
RNFWEKPDDFYPEHFAPEAVKNRHPFAFLPFSAGPRKCIAQQYSTTYMKIQLCTILQNYEIQCQYNTKNI
KLTTDISVRPVQGYMLKIRKRRV 5042
CYP352B1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
46% to CYP352A1 Tribolium castaneum
CYP353A1 Tribolium castaneum (red flour beetle)
GenEMBL XP_974117, protein , AAJJ01000087.1 genomic
35% to CYP314A1 Tribolium, mito clan
MSIIASWLRYNKFHTQLINIKYSPVNKSFKNLPTLKSYPVIGHSYLFFPR (1)
GKYKSERLTEAFVDISKTLGPIFKLNLGGSA
63033 MVVTLDPDHTRILFQNEGTRPERPPFPALLHFRRKRFSSVGVVPGNGEEWYKMRKGVTPLLKLQLIEPYK
RQQEDIAKTFVEYVKTHRDENFVLRDIFSHLLKFTIEGHRFHCLFSDNLETEQIIKASVDFMDGLYGTLI
EPPFWKLWKTPSYKKLESSHNTIYKILERHLEQIKFQFSENPESVKESQPYMYSLFSNDQLSWDDKIMLA
MEIFLGGIDATATTISFTLHYLSQNPEIQKMARSQ
NTDFLKACIRETLRLSPTAGGNSRFLSNNTVIGGY
LIPKGTLLLSLNSGMARDERYFKDAQKYRPQRFVRATREDFHRYASLPFGHGPRMCPGKRVAENEIILKN
FALESAGSSDVGMVFRMNRIPDKPISVRFVDTNH
CYP353A2 part 1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 4
56% to CYP353A1 Tribolium castaneum
aa 74-195
CYP353A2 part 2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Dec. 10, 2010
mito clan
Clone name seq 29
56% to CYP353A1 Tribolium castaneum
aa 297-461
CYP353A2 Leptinotarsa decemlineata (Colorado potato beetle)
GO270917.1 C-term EST
53% to CYP353B1 aphid
100% to CYP353A2 part 2 C-term
Mito clan
SAFSSVTSTDERYFENTSTFLPDRWLRDSERKFHKFASLPFGYGPR
MCPGKRLAENEIVILLKQILRKYSLEVSDTSPIGMVYRMNRIPDRVIDIRFLKH*
CYP353B1 Acyrthosiphon pisum (pea aphid)
LOC100161881
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
45% to Tribolium castaneum XM_969024.1 CYP353A1
mito clan
MTFRQFKPFSSIPEPKRWPLLGHTHLFIPKIGPYDSQHLTEAMGDIERMLGPVFKLMLGGKTMVVTTRVEEAKTLFAHEGKHPARPIFPALNLLRKKPFGTGGLVSE (2)
NGVEWYRLRKAIAPLMSKNIYESYIPQHKKAAVDFIDYIKLNRNKDKCLKDMFYHLTKFSVE (1)
AISIVSPGLRIKCLNTTMSECFVEAGNKFMDGLYNTLKEPPIWKFYKTNAYRNLESSHSTCKNFIDEYLKQTHEHNALVNAINTNSNLTNTDINLLVLEIFFGGIDA (0)
TATTLAMTLFYISQDESVQKACEEDVLQGTNAYIKACIKETLRLSPTAGANARYLPKTTVIGGYEIPANTLVMAFNSLTSTKEKYFKAPLEYQPSRWLRNSNIQKFDPYASLPFGHGPRMCPGRHVAMQEMTILLSE (0)
LIKNFKISLPAEHAKNIGMIYRMNRIPDSRIDIIFNNK*
CYP353C1 Trialeurodes vaporariourum (whitefly)
CYP353D1 Laodephgax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
54% to CYP353C1 Trialeurodes vaporariourum
EXXR to heme region
CYP353D1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
incomplete
CYP354A1 Bombyx mori (silkworm)
AV399740.1 EST N-term 203 amino acids
BAAB01211873.1 exons 1,2
AADK01025884.1 exons 3,4,5,6
BAAB01157630.1 exon 7
AADK01034838.1 exons 7,8
AADK01018486.1 exons 8,9
This sequence assembled from genomic DNA and ESTs
A tree of 155 CYP6 and 9 sequences places it outside CYP6 and CYP9, but
It is a CYP3 clan member.
The stop codon in exon 4 seems to be a seq error
when compared to the CYP354A2 cDNA sequence.
MNFSPGTVQILQFIQNDWKL
605 ILILTLLIFIYYYYTNTFDYFEKRGVPFKKPIIFLGNLGPRLKAVKSFHQYQLDIYQYFKGHPYG (1) 799
1277 GTFDGRRPVLHILDPELIKAIMIRDFDHFTDRNTLNSMEPRYLSRSLLNLK (0) 1429
4244 GLEWKGVRSTLTPAFSSSRLKNMIPLIQQCSKQMVEFLKKF (1) 4027
2588 DGKEIEMKQTMGHFTLEVIGACAFGIKCDALSNENSRFVK (0)
1717 VAEKFDYMPKYKRVILLMLLVFMPKMIR*LRLSFLNIEYTG 1598
ELVRMLQAAKAERRSSESK (2)
KGDFLQILIDFAAKETAQNDTAKREI (1)
LLDDDTIDAQSLLFLIAGY
ETSSTLLSFAIHVLATKPDLQETLRAHVQEMTKGKEMSYELLAQMDYLEAFLQ (1)
ETLRIYPPVARVDRICTKPYIIPGTTVHVGV
GDAVAIPVYGLHMDEDIYPEAREFKPERFMDDQKKDRPSHLYLPFGAGPRNCI (1)
GLRFAMISAKIAMVALMKNFKFSVCSKTMDPIDFDKRAVLLKSAKGLWVRIELIDLS*
CYP354A2 Antheraea yamamai (Japanese oak silkmoth)
GenEMBL AB265182.1
Yang, UP., Onodera, CO., and Suzuki, K.
67% to CYP354A1 of Bombyx mori
FTLEVIGACAFGIKCDALSHENAYFYK VAENFDYMPKIKRVLIF
LCMIFMPKLLTYLNVSFLHLKSTD ELVRMLQAAKAERKRLNSRENDFLQILIDFAKKE
YTELENTNTAKYLDDDTIDAQCLLFLIAGYETSSTLLSFAIHELAINTQLQSKLRAHI
KEVTDGKEISYELLSELTYLDGFLL
31 amino acids of EXXR exon missing here
GDAVAVPVYGIHMDPKYYPEPHELRPERFMHSE
KKERPSHLFLAFGSGPRSCIGSRFAMISAKTAMMSLMKNYKFSTCSQTTYPIEFDKRS
VLLKSETGLWVRFEPL
CYP354A3 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_159, 97% to Contig_266 68% to CYP354A1,
38% to CYP9E2, 35% to CYP6P10v1
HAH007118 100% to Contig_159
HAH014359 1 aa diff to Contig_159
CYP354A3 Heliothis subflexa (moth)
No accession number
Hanna Heidel-Fischer
submitted to nomenclature committee June 30, 2011
98% to CYP354A3 Helicoverpa armigera
CYP354A4 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_266 62% to CYP354A1
HAH010529 100% to Contig_266, 97% to Contig_159 354A3
CYP354A5 Manduca sexta
No accession number
Yannick Pauchet
Submitted to nomenclature committee April 7, 2009
confidential
CYP354A6 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
56% to CYP354A1 Bombyx mori
CYP354A7 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
52% to CYP354A6 Heliconius melpomene
CYP354A8 Plutella xylostella
Gene number CCG014440.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
66% to CYP354A3 Helicoverpa armigera
missing the N-terminal 68 aa
CYP354A9 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
71% to CYP354A3 Helicoverpa armigera
CYP354A10 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP355A1 Litopenaeus vannamei (Pacific white shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
37% to rat 3A1, 55% to CYP355A4 (DY307252.1 DW584917.1 DY656871.1
DY656786.1 Green Shore Crab Carcinus maenas ESTs)
Note: first CYP3 clan member from a crustacean
Clone name Lv01
CYP355A2 Litopenaeus vannamei (Pacific white shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
89% to 355A1, 69% to 355A3, 39% to 9E2 in 3 clan
Clone name Lv02
CYP355A3 Metapenaeus ensis (shrimp)
No accession number
Shirley Chan
Submitted to nomenclature committee August 29, 2006
69% to 355A2
Clone name Me01
CYP355A4 Carcinus maenas (Green Shore Crab)
GenEMBL DY307252.1 DW584917.1 DY656871.1 DY656786.1 cDNA
55% to 355A1, 35% to 6a17 Drosophila N-term, 37% to 9L1
CYP355A5 Litopenaeus vannamei (Pacific white shrimp)
No accession number
Yuan Liu
Submitted to nomenclature committee Jan. 4, 2010
85% to CYP355A2
CYP356A1 Crassostrea gigas (Pacific oyster)
No accession number
Alfonso Bainy
Submitted to nomenclature committee Jan. 19, 2007
Similar to CYP17 sequences and CYP1 sequences
In the CYP2 clan
34% to CYP17A1 of zebrafish, 38% to an unnamed sea urchin
sequence XP_789963
CYP357A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-1, 36% to CYP6AG3 Aedes
Pediculus genome site
CYP357B1 Laupala kohalensis (cricket)
GenEMBL EH642348.1 EH638304.1, EH632898.1 EST
82% to CYP357B2 42% to CYP357A1, 38% to 6AG2, 40% to 6AG3 N-term only
MLQEWINLYWTACTVVFLTVCYTYLTWNNDYWKKRNIP
FVKSKIPFGNFTDVFLGRRTVGELMEDIYRATSGKPFAGFWRFRQPGLLIREPENIKDVL
VKEFSSFQENGFVVDPHLDPLLAKNPFFQVGERWKKTRSILTPNFTSGKLKPLYTLMREV
SAELVEYLKRETGSDGLEAKDLTSKYTMEMVATCGFGI 717
CYP357B2 Laupala kohalensis (cricket)
GenEMBL EH629712
82% to CYP357B1 EH642348.1 EH638304.1, EH632898.1, 36% to CYP357A1
MLQEWINLYLAACVLVFLTVCYTYLTWNY
DYWKKRNIPFDKPKILFGNYTNVFLGRTTVGEVMEEIYWMTAGKPFAGFWRFRKPGLLIR
EPENIKDVLAKEFSAFQENGFVMDPNLDPLMSKDPFFQAGEEWKKSRSIMTPNFTSGKLK
PLYTLMREVGAELVEYMKKTEFGSDGLEAKDLTSKYTLEMVATCGFGIKANCFNDPNAQL
KKMTRQLLEPDFWTNMKFLVGNYVPILGSLLKLRFVPSDVDKYYRQIITDVVGHR
CYP357C1 Blattella germanica (German cockroach)
No accession number
Ameya D. Gondhalekar and Mike Scharf
submitted to nomenclature committee Nov. 21, 2010
47% to CYP357B2 in the N-terminal only
CYP3 clan member
CYP358A1 Pediculus humanus humanus (body louse)
XM_002422874, predicted mRNA not completely correct
Revised seq given below
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph6-2P, 40% to 6BE1 Apis (no cys),
probably not a pseudogene since Locusta migratoria and
Homalodisca vitripennis also have similar P450s as ESTs
EG367165.1, CO826097.1, resmbles CYP408 family
Pediculus genome site
(2) LINRAYAYWDRKNVSGPRPVYVYGSWKGLNEK (0)
FLGSEDIINSKKYGKIYGTYDGITPNLLVTDPKIIKEILDTNSDNFKD (0)
VRVNSENSIILKDSLLSLCGGEKSEVQILTNSLLNPQKLGKLFPKLVSSVEILIRTISKNRQ
ENNCLDVTSSISEFIDDAVANSIFGIELDADVEFKEEFVNNSRKIFSVSDPNALTSLRF
VLYENYFKEFWICPE
KTLQYFVNLAITGITDTTANLNSILEEKSSSLVQLLVEAAEEEKKLKIKKKDDEEDDS
DDVILK
DNVIISKCIATMLSLSNATKTTVIL
GLYALAKNEIHQEEVFKEIQKNKTKG (0)
KLTYEDIQNLNYLDKIVKEVLRLYPFEFRLEK
LCVKKTVIGNVEVDENVKVSIPLYALHRSEDIYPEPEKFEPERFAENSSENPSPFSYL
PFGQAGINGSDFSIQLGILASKLTLFKLIEKFQFSIEQKDKSLSGLFKQGLTRIPRPE
KIELFVKNRGEEEEEEGNNTNN*
CYP359A1 Pediculus humanus humanus (body louse)
No accession number
Reed Johnson and Barry Pittendrigh
Submitted to nomenclature committee March 14, 2007
Ph343, 34% to 343A1 Apis, 36% to 15A1 Diploptera punctata
Pediculus genome site
CYP360A1 Daphnia pulex (water flea)
CYP360A2P Daphnia pulex (water flea)
CYP360A3 Daphnia pulex (water flea)
CYP360A4 Daphnia pulex (water flea)
CYP360A5 Daphnia pulex (water flea)
CYP360A6 Daphnia pulex (water flea)
CYP360A7 Daphnia pulex (water flea)
CYP360A8 Daphnia pulex (water flea)
CYP360A9 Daphnia pulex (water flea)
CYP360A10 Daphnia pulex (water flea)
CYP360A11P Daphnia pulex (water flea)
CYP361A1 Daphnia pulex (water flea)
CYP361B1 Daphnia pulex (water flea)
CYP362A1 Daphnia pulex (water flea)
JGI Protein ID:212880
MIASIVLGRLNGRLGTTYQQLVNQQARIVQR
SKASVAASPEVVLKNGANVSKVVEDAEWNNAKSFDEMPGLR
SVPILGTSWAMLPVVGAGIPITR
ILELYKLQFEKHGYIWRDI
IPGAPPIVSTTRPEDAEKVFRTEGKFPERPGFETLKA
YREKRIEQFTSAGILAGNGESWWNVRSKAQQPFL
KTKNVNNYIPVLGQIAQEFIDRIRLIRQENNEMKPD
FVNEMYRWALESVGVVGLNTRLGCLDPNL
APDSEAQKMISAANLSFAAVNELEYGLPLWKYFSTPKLRS
LYEAQDFFTDTALKYVQQTLE
VMTNRPADSDEDPSILEEFFIRG
MSLKDATGMVIDMLMAGIDTTSHTTSFLLYFLATN
PEKQEKLRKEILSVLGPKGTQVITPSDLNELHYLKACIK
ESLRLRPAAVGNARIIDKELVLSGYRVPKG
TLVVLLHQLMAQM
DEYFSNAKEFKPERWIKGDPEESHH
HKYVVLPFGFGTRMCIGRRLAELEMWQLTTK
ILQNFKVEYHYEDIGCLSRI
VNAPDQPLRFKFIDLN
CYP362A2 Daphnia pulex (water flea)
JGI Protein ID:245478
MLELQKLRF
KQFGYIWR
DIVPGRPPIVYTADPEDVEKLFKTEGKHPVRPGMETIKAYRA
QRIQDFSSAGILLSSGEEWWNTRSKAQHTFL
KPKNVTHYITELSEIADDFVNRIRLIRPENNE
MTPDFLNEMYRWALETVGVVGLNTRLGCLQQDLA
PDSEAQKMIDAANFSFSAINELEHKFPFWKFFVTPMLRK
LYDAQDFFTETTIKYINQT
VEALKGSSFDSYLSIIEQLLVNGMD
PSDVTTMVIDMLMAGVDTSANTSAFLIYYLAKN
PDKQEKLREEIFSVIGPKGSPITSNALNNLPYLKACIK
ESFRLMPAANANARITDKDLVLSGYSIPKG
SLVVALHQLMSHL
DENFPDAQKFIPERWIKGDAQESKTH
HPYVVMPFGSGTRMCIGRKLAELEIDQLIIK
LLQNFKIEYHHEDMSCFMRV
TNMPDQPLLFKFIDL
CYP362B1 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:125634
41% to CYP362A1 Daphnia
42% to 362A2
MDEKNIPGPRS
WPFVGSLYKYTPIVGEYTFHDR
DATSSKMYKKYGKIVR
QEITPGIVWYHLFDPDDIETVFRNESKAPQRMLLEGVVE
YCKQRNRSPGINVNGEKWKRLRSNSQKPML
RPRNVSAYIPLQDRIGADFIKRLRSIRDPETNE
IPDLLNEFYKWAVESIGVVIFDKRIGTLDGNLG
PDSEAQKFIQASNSAIDAMYHTTIYWPLHRGRATAKWKQLCS
SLDFIWEVSMKYSREA
MQKIKKGNVGKDSSILGSFLSDPDISF
EDCLALSTDLLSAGVDTTSHTTAYLLYHLAAN
KKSQTKLQEEIDRELTPGEAITAQTFDKLQYMKAVLK
ESQRLNPIVGSFSRRTEKDLVLSGYKIPTG
SFVFCEVAVMCGM
SKYFSDPDEFIPERWLRSESCQKQGDFH
PYVFLPFGHGARSCIGRRFAEQEVYLLLIK
LMQNFNVENHHGYIGRRTRL
INTPAKPLKFAFIDRR
CYP363A1 Daphnia pulex (water flea)
CYP364A1 Daphnia pulex (water flea)
CYP364A2 Daphnia pulex (water flea)
CYP364A3 Daphnia pulex (water flea)
CYP365A1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP365A1 Plutella xylostella
Gene number CCG009934.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
74% to CYP365A1 Bombyx mori
missing the C-term 139 aa
renamed as the ortholog, formerly CYP365A2
CYP365A2P Plutella xylostella
Gene number CCG016740.1, CCG009935.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
69% to CYP365A1 Bombyx mori
renamed as a pseudogene, formerly CYP365A3P
C-term part of this gene is CCG009935.1 (old CYP365A5)
CYP365A1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
renamed as the ortholog, formerly CYP365A3
CYP365A1 Helicoverpa armigera (cotton bollworm)
CYP365A1 Chilo suppressalis (striped rice stem borer)
CYP366A1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP366B1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
44% to CYP366A1 Bombyx mori
CYP366B2 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
80% to CYP366B1 Heliconius melpomene
CYP366C1 Plutella xylostella
Gene number CCG005514.4
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
68% to CCG005515.2
46% to CYP366A1 Bombyx mori
38% to CCG010920.1
CYP366C2 Plutella xylostella
Gene number CCG005515.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
68% to CCG005514.4
43% to CYP366A1 Bombyx mori
CYP366D1 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
53% to CYP366A1 Bombyx mori
CYP367A1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP367A2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_265 57% to CYP367A1, 35% to 4D17 N-term
HAH010069 100% to Contig_265
CYP367A3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
CYP367A4 Plutella xylostella
Gene number CCG000833.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
63% TO CYP367A1 Bombyx mori
MISSING THE HEME SIGNATURE SEQ
MISSING FIRST 60 AA
CYP367A5 Plutella xylostella
Gene number CCG004650.2
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
96% TO CCG000833.1
CYP367A6 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
70% to CYP367A2 Helicoverpa armigera
CYP367A7 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP367B1 Bombyx mori (silkworm)
No acession number
See silkworm page for details
CYP367B2 Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_188 53% to CYP367B1 partial N-term seq.,
42% TO CYP367A1 whole seq, 29% to CYP4M7
CYP367B3 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
CYP367B4 Plutella xylostella
Gene number CCG006271.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
96% to CCG000834.1
59% to CYP367B2 Helicoverpa armigera
CYP367B5 Plutella xylostella
Gene number CCG000834.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
96% to CCG000834.1
CYP367B6 Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
77% to CYP367B2 Helicoverpa armigera
CYP367B7 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP368A1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CO742010, CO508667, CF544158
David Drane
2clan 33% to 2J2 partial seq N-term to I-helix
name conflict with Apis formerly CYP343A1
MDWISICIAVV
TAGLALLLWLKPSRPKNSPPGPPAIPIFGSFHFFAKQPHIAILKAKEKYGDTYMIHVGRR
PVVILSNYNTVKKVFGDDLVSGRDNESYIRYDASTLAESGLIFSEGDLWKTHRRFALSTL
RDLGMGKNWLEDTIIGEVDAIIQRIRETNKTPFNPKVQLTNSVSNVICALIFGQRFS
LDDPNFSKLTNLITENIASVPYDQIVLTLPFLMWFP
NPVRAQIMSARNNLAKLNVFMSARIKEHKNADRRTDVEDYLHAYQTEKETGNKTDKAAQA
TFDETQLLASLFDLFAAGTET
CYP368A2 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CO741868.1
David Drane
2clan 46% to 343A1
N-term only
name conflict with Apis formerly CYP343A2
MDYFSVITAVLAALLALTYWLKQSRPKNYPPGPPGLPFVG
HTFSVGSPRRPAATFMKWKAQYGDIFSVKLG
CYP368B1 Hypsibius dujardini (water bear, Tardigrade)
GenEMBL CF075875.1
David Drane
2clan 42% to 343A1
N-term only
name conflict with Apis formerly CYP343B1
MLEYILAGLLLILTIAWFTLGVKRSTTLPPGPPPRPIVGNL
GRLRGKSGKERYRTLAKLVDDYGKDGVATIYLGSQPVVFVTNFETLKTIVHSDEMSGRPT
SVRDEFFHRKGLIFTDGDEAWKEQRRFALSTLRDFGMGKTWLQDLVIEEAVELVEDIKNA
NGKPVNPIQYLTPSISNVICAISYGQRFSHKDANFQRLTSLV
CYP369A1 Apis mellifera
Name conflict with Nereis, formerly CYP342A1
MISFLFIIFLLLIIYKIYNSVIHVSSNTPPC(1) LPRLPIIGSYWHLLWHDYEYPYNGIIHYVNKLQSKIVTCYFGSHKTIIANDYKSIKEVLTK
QEFNGRPINVDIVLQRAFGKSL (1)
GIFFTEGTLWHEQRRFALRHMRDFGFGRRHEIFETNVMEEIAILVDMLKEGPINDEEK (0)
KFLKNGYACFPDILYPYVANVILNIMFGERFDRSQYHKLIYFCESSMMFQKSLDTSGGAIF
QFWFLKYFGNIFGYTNAIKATYQMINFIE (0)
EYIDNKKDLDDYDKGLIGRYLKILKEKNNITSTFSQKQLIMTLVDFMFPATSALPSALVHA
IKLVMHHPRVVNNIQEEIDRVVGTGRLVTWSDRKN (2)
LPYIEATIRESLRYETLTPLSVFHKTLKKTTLCDYDIPKDTLVVTNLVALNTDPDLWGDPE
NFRPERFLDENNELRKDFTFPFGF (1)
GHRVCPGETYSRYNMFEVFAVLMQNFNFSFVEGEPTGLDDKESGLIVTPKKTWIQVKARNMK*
CYP369A1 Linepithema humile (argentine ant)
No accession number
CYP369A1 Pogonomyrmex barbatus (seed-harvester ant)
See Pogonomyrmex page
Reed Johnson
Submitted to nomenclature committee June 3, 2010
54% to CYP369A1 Apis mellifera
CYP369A1 Solenopsis invicta (fire ant)
See Solenopsis page
79% to CYP369A1 Pogonomyrmex barbatus
CYP369A2 Solenopsis invicta (fire ant)
See Solenopsis page
78% to CYP369A1 Pogonomyrmex barbatus
CYP370A1 Daphnia pulex (water flea)
formerly CYP15D1
CYP370A2 Daphnia pulex (water flea)
formerly CYP15D2
CYP370A3P Daphnia pulex (water flea)
formerly CYP15D3P
CYP370A4 Daphnia pulex (water flea)
formerly CYP15D4
CYP370A5 Daphnia pulex (water flea)
formerly CYP15D5
CYP370A6 Daphnia pulex (water flea)
formerly CYP15D6
CYP370A7 Daphnia pulex (water flea)
formerly CYP15D7
CYP370A8 Daphnia pulex (water flea)
formerly CYP15D9
CYP370A9 Daphnia pulex (water flea)
formerly CYP15D9
CYP370A10 Daphnia pulex (water flea)
formerly CYP15D10
CYP370A11 Daphnia pulex (water flea)
formerly CYP15D11
CYP370A12 Daphnia pulex (water flea)
formerly CYP15D12
CYP370A13 Daphnia pulex (water flea)
formerly CYP15D13
CYP370B1 Daphnia pulex (water flea)
formerly CYP15E1
CYP370B2 Daphnia pulex (water flea)
formerly CYP15E2
CYP371A1 Helobdella robusta (leech, annelid worm)
JGI Protein ID: 81128
47% to CYP371B1, 35% to human CYP27A1
MDLNLFQ
ASLHRKYGKMFREKWG
PKWQVHVSDPDLIEEIYRHEGRYPFRPSLQPWLLYRQ
IKNLPHGITTAQGMEWQHYRTEFGKRLF
CPSATKSLIEPLSNVADDFVTKVETVLADCNQNFDDNCNKEIYFA
KQLPNISYLWSLEAAGSFLFETRLGCLAPS
IPTRTQKFLDSLQEMMTSSLYLIVGEKIHQRLNTRFWRKHEK
SWDNIFSFGKTLID
EKLLSLESSEEVTGPYLSHLLKNKN
LTMNQIYTNITELLMAGSDTTANTFCFVLYMLANN
PDKQNLLRQEIQSIMSMSSFAASHNHLEDMKYLKCVIK
ETMRLYPVVTMNCRVLNQDIQLDGYTIPKE
TLFVMNHYAASID
EDNFHDPNKFLPERWLREGDVSQQQHKVQQQTDIKK
HPFASLPFGYGSRSCLGKHVGKMELMVTLIK
VLDKFDVKPLVEQQDLKPVLRT
LLTPGQLVPVRLCRRY
CYP371B1 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:199669
47% to CYP371A1, 37% to human CYP27A1,
MALRRPLRSCV
QVQSRGITEARVGAADQWNQGGTRDDQHAVVRTMQELRGPV
GWPVVGNFLTYLRKKNRGRMHEVQTLEASSIQVLSTEEIYC
VTKQAEQHAQYGRMFR
EKWGPHWQVHISDPDLIAQVYRQEGKYPNRPSIRS
WQLYKEKNDLPMGLTTAEGKTWYKFRSEVSKQLL
CPRSMSRMVEPLNNVSNDFIQKLRHTRKSRGV
DHLKEQLQNELYKWGMEGAGTLLFETRLGCLDVQ
ISERSELFIAAVTEMLESSLPLIIGETFHQKWNTKFWKRHSD
AWDKIFQIGAEYINEKLLAM
ENSYLRGEKNHSGELLTHLLANKA
LNLEEIYSNITELLVGAVDTTANSTGFILYLTAAH
SHVQEKLHDEVSRVLGDRQEITGTDLQNLPYLKATVK
EALRLYPVATMNCRILEADINLNGFRIPRK
TLFVLNHYAAGRD
PELFSNPDEFIPERWLRGSRSLDH
HPFASLPFGFGARSCIGQRMAKLEMHILLAK
VIQNFKLNVDESREFKPSLRT
LLTPGDCVPVEFTDR
CYP371C1 Lottia gigantea (owl limpet)
JGI Protein ID:239424
42% to CYP371B1
MNACSPCQLAPSTIGTYLYKRGFHKKYGKIFKERLGPVTNLSISDPALVEE
ILRTEGKYPFRPPYQSWVLYNELYNRKGGTMTADGEHWKKCRSVMNPKFLRPKAVGEFVE
GINGVVASFVDRLRLLKDATGDGEPIPHLPNELSKFTMEALGWVLLDKRLGCLEEHVEEK
VQNFISSIATMFLTGHQLMIFANVHQKLNTKPWRNHVRSWNTIYEIAQDYIDERMKDVAE
RLSGDIKEGERVDFLTYLVGSGKLSREEIYVNITEVLLGGVDTAANSFSFLLYSLAKHTE
SQDILLEEVDRVLGGKVCSYEDLQRMPYLKAVVKETLRLYPPIPINARVMQEDTVIDNTL
IPKGTIVLLNKYTMARDEKIFTNPDKFIPERWLRAEAKDWHPFSSIPFGYGARSCVGRRI
AETEIYLATVGICQKFRMSVSDKFDIKPSVRTQLTPGPELPILFTER*
CYP372A1 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:201165
32% to 235674LotGi, 34% to 125634CapCa
36% to CYP372B1, 31% to 235674LotGi,
33% to CYP373A1 Aplysia
note revised from JGI gene model, exon 43 lengthened
exon 6 shortened
MGRSQKLKPRAPSERITFEVMTKPLRCMPGPRCWPGVGSTLEYSPL (1)
GRYSFDRLHVAKKENFARYGRIYQERMGPAVTLIQVFDPEDV
ARVLRADGKCPMRPSIPITTVAHKRDGIPLGLGSL (2)
NGTDWHDVRKAIHRLMMRPGAAAVYLPVQNSVADDLVSF
IMSERKADGFVPNFLNLVTKYAME (1)
SIGAVCFKSRLGCLRRNPPQSAQELLRASNDMFTAMQNTAFAFP
WYALMRTHFYKH (2)
IAQRYIANIQENEQSDGDFADCPHFFGTLLETPGVTMER
VIGLTSELFIAGIDS (0)
TANALSFVLYNLSRNPDKQEILRD
EISRVLPNRKRLEKADLEEMKYLKACVKESFR (2)
LNFPIEGGTTRILAKELELSGYVVPEK (0)
VIVAFNNQTMCLQEQYFDAPEDFIPERWLKSGSGSLRAP
PRYVFLPFGYGPRMCIGRRFAEQEIYLAIVK (0)
IYQNFRTEYNGDAIGMINRVFTAPDTPIAIKFTKL*
CYP372B1 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:136114
JGI gene model modified
MFTLSNRAGETSPPLGCPFHEPTSATQSDNEASTAQTGHHKSYADMPGPK
GLPGIGNALAYSRF (1)
GNHKFEKILDSRLSYMRKYGKVYREKLGHMEMVHIFDPSDIATMFREE
GDHPSRGKIAHVELTYLKRSKKFISFAYI (2)
DGAEWARQRAAIQRLMMHPTAATRYINWQTPVAQDF
VQYIDENRNEEGIIPNLYEDLFKYTME (1)
SIAAVCFGDRIGVFDKNPESMKDADILSNSITENNKVFRNCMFSFP
WYQYFRTPLYKRYEKVADQMKAWVKLGEKIQLILIYDFYNRIMG
KHVDRCSNKIEARGLRTGPDVVNPFGG (0)
TGNSLAFFLYNLAAN
PEKQEVLYREIENVLPNKQQPTAKTFKNMPYLKAALKESFR (2)
LNFPVYGGSGRVMPQDTVFGNYVVPKGVFIFANIAAMGRM
EEHFPEPAKYHPERWLRGENASMGATWKED
SGFLSLPFSHGLRACPGKRYAEQGLYLAAIA (0)
ILQNFKLSYDKPEPVEMLHLPFTIPDRPLDITFTQRTSC*
CYP373A1 Aplysia californica (California sea hare)
GENSCAN_predicted_peptide from gi|112609286|gb|AASC01065054.1
added first exon to model
MLPSKTQTWILPRGRELLCSVCSQRCLSAPPSGMFKDQLLTANTKHEGQVKHSQTALPFSKM
LGPKGARRIPYIGTLLMFKPFSPYTIDTFDRMVSSKHDKYGAIFRMR ()
MGKEYTVFTENVADVVTIFRTEGPYPRRRLMNLNKV
FRERNNLPLALGGLSGPEWHELRRPLNPLLN
KPQMCLHYLSAQNNVADDFVKRLGETTLSREQ
QCEEFFKYAAESIGVVCFNCRLGFLNSDLS
SSRDKHNLLEAFKTVMHCNYVAMVGLERRYQFTEQDEFYQ
LYSRAMKLIAHESMQYVEAVMSGLKAKQT
SGSQTIEQESDLRAYIETNLLASLIVNSN
LEMNKIIAIIESLLVVGTDSTAKNLAVLLYNLARH
PEKQQKAADEIMGIMGENEPVTPKTISEMHYLKACVK
ESMRLNFPTANGTMRILNQDTVLSGYLVPKD
TNVILGMRRIAHD
PRYYPDPESYKPERWLRQKQGSQTRRDEVVSR
QAFTYLPFGHGARSCIGRRFAEMEIQVAAAK
ILQKLQVRVDKSYEGLDPVYTP
FITPRVPIPFVFEKRKT
CYP373B1 Lottia gigantea (owl limpet)
JGI Protein ID:235674 36% to Aplysia
MITSRLMRTLVRSSVCRFQSTTGAGVAESDDVVDSPRPLSDMPGPGG
IYRMPYLGLAFMLKPF (1)
TNISQQDFHLLLDQLHDKYGEIVRMKVGNGDWVCTA
DPHDIERIYKSEGKYPKRFGLLMIEHHFNKTKKEKTIAFL (2)
QGPKWAELRQHIQRKLV
RPKSALYYIDGQASVSRDFVERLKTTKPEDVRDLLFSYSTE (1)
SIGVVCFNKRMGFMDEEMDPEVADYFENNKQFFTLLNKGIT
GFPFYKYFETPMYKKVINTYEKTYS (2)
FGRKQVEESLEQTK
KMKEEGTFDAEEPNFMMSLLAEERLTTDQISGIVLDLLIGGTDS (0)
TAKTLEVMLDVLARH
PEEQEKLYKEVHQFLGDDGDPTAENLPKMKYLVACCKESMR (2)
MNYPVVSGSNRILTEDIILSGYHVPKN (0)
TLILLNNRRMVLDRKYASDPDRYIPERWLRDAEGNKNVNI
PSVGMIPFSIGVRNCVGRRFAEQEIYLATAK (0)
IIQKFKVGLVNPEVKNTITYQTFATLQDPAMLTFTSRR*
CYP374A1v1 Branchiostoma floridae (amphioxus)
JGI Protein ID:155528
Model short at N-term and C-term added missing parts
scaffold_501:440590-430771 (-) strand
440590 MKRAWLQHLVAKKLGADAVSIGRSGGETSTFSPPTTVHGHGDYVGTGPTA 440441
440440 QPCTARPFEDMPGPRGLPLIGTLLDYTPL (1) 440360
437911 GPFSLKKLHE
SFFERYRQFGKISKET
IGNKCFVSVYDPRDIETLFRTEGPNPSWMQLMALGEVRK
RLGKPLGMINETGQKWRQLRYAAQSKLL
NPKSVSSFVPVLDEISRDFVEKLRTGRSAATL
EPTIDLDAELRKWSLESVVSATLGIRLGCLQKHRQI
PDKDTEDLLQSSDAFLDTWSKLELGPPLYMLYPTKTWRKFLRA
NELWL SAAGRMIDRSL
DRSESERDPLQPEVTLLEHIVTRKE
LTPDDVVMIITELIFAGIESTAVAMTYNLYTMAKN
QHVQEKVRREVNAVVGKSGKVTQDALKSLKYVKACIK
ETS RVLPAFSMRNRILDKEIVLAGYRVPPN
VIIRVLTHVTGQL
PEYVVEPDRFAPERWLRDDTTIPKP
HPFAVRPFGVGTRSCIGQRLAEQELGILLAK (0)
430875 MIQQFHIECDGEMEQIFNIANKPDLSGTFKFTEL* 430771
CYP374A1v2 Branchiostoma floridae
JGI Protein ID:73459,
scaffold_44:2304248-2294891 (-) strand)
fgenesh2_pg.scaffold_44000117
allele 3 aa diffs to CYP374A1v1
2304248 MKRAWLQHLVAKKLGADAVSIGRSGGETSTFSPPVTVHGHGDYVGTGPTA 2304099
2304098 QPCTARPFEDMPGPRGLPLIGTLLDYTPL 2304012
2301587 GPFSLKKLHESFFERYRQFGKISKETIGNKTFVSVYDPRDIETLFRTEGP 2301438
2301437 NPSWMQLMALGEVRKRLGKPLGMINE 2301360
2299617 TGQKWRQLRYAAQSKLLNPKSVSSFVPVLDEISRDFVEKLRTGRSAATLE 2299468
2299467 PTIDLDAELRKWSLE 2299423
2297804 AVVSATLGIRLGCLQKHRQIPDKDTEDLLQSSDAFLDTWSKLELGPPLYM 2297655
2297654 LYPTKTWRKFLRANELWL 2297601
(gap of 111 aa)
RVLPAFSMRNRILDKEIVLSGYRVPPN 2296379
2295729 VIIRVLTHVTGQLPEYVVEPDRFAPERWLRDDTTIPKPHPFAVRPFGVGT 2295580
2295579 RSCIGQRLAEQELGILLAK 2295523
2294995 MIQQFHIECDGEMEQIFNIANKPDLSGTFKFTEL* 2294891
CYP374A2 Branchiostoma belcheri (Japanese lancelet)
BAF61103
side chain cleavage enzyme
87% to CYP374A1v1, 31% to 27B1 hum,
38% to CYP374B1 Strongylocentrotus purpuratus
1 mkralhqhlv arklgadaat igrtggdsgt fspptsvlgh adhvgtgptt qpcsarpfde
61 mpgpkglpli gslmdytplg pfrlkklhes fferyrqfgk isketignkr fvsvydphdi
121 etlfrtegpn pswmqlmalg evrkrlgksl gminetgekw rqlryaaqsk llnpknvccf
181 vpilddiaqg fvenmrvgrt atlepsidmd aelrkwsles vvsatlgirl gclqtnrqip
241 dkdtedlles sdafletwpt lelgpplyml yptktwrkfl raneqwlsaa griidrslds
301 ngsqrdplqp evtllehivt rkeltpddiv miitelifag iestavamty nlytmaknqa
361 vqenarrevn avvgkggkit hdalkslkyv kaciketfrv fpvfsmrnri ldreivlsgy
421 rvppnviirv lshvtgqlpe yvpepdrfap erwlrddtsm pkphpfavrp fgvgsrscig
481 qrlaeqelti llakmvqqfh iecdgemdqi fniankpdls gtfkftelln
CYP374B1 Strongylocentrotus purpuratus (purple sea urchin)
XP_001187275
1 MLPASVGRTS ACRMASMAQQ ILHRHVGTMV TSEHLEDAKP YDEIPGPKGV PFFGSLFDYT
61 GLGPYKLDKL HEATVDRFRN FGPIFKETLA GVTHVHIIDP TDVRELFRNE GRSPKRTPID
121 AMVKYRRTRK RHIGMANTEG EEWQRLRKPV QHLLMKPQSV YAYIPIMEEC ADDFVTLMKE
181 TQDIESQEVP EFNHKMQRWT LESVCAIVFD TRMGCLNTGL DNNPEALDMI VSVSNFFDSL
241 KDLTFSFPFW KFGITTKAWT KFTEAQDYFF GMSKKYATIA LDRMKSAVGT STQSESEGTF
301 LECLLARRDF DIDSLCDLMN DLMIAAVETT ASTLAFNLYC LAKNPEVQER VFQEINQAIP
361 PGTKITAQSL QNLPYLKACI KETVRVFPTV DGTNRIPSRE IALAGYRIPP DTIVRIHCIA
421 GLMEEYFPSP EKFKPERWLR GDAECENIDP YLILPFGYGS RMCTGRRMAE QDLYIMLIKI
481 VQNFKIEWHH EEDMELIFRL TNVPDRPAQF RFVSRT
CYP375A1 Nematostella vectensis (starlet sea anemone, Cnidarian)
JGI protein ID:107622
MGRRFLER
HTQNIERYGKL
YKREAQSTIVYVADVNDAEKILRYEAKYPHRIEDPVISH
YMAKRQAIPGVFFSNGNLWYKHRRAISKKLL
VPRMVEQYVPTYNAIVDDFLARLSFIKGPEGSSYENE
VSNLQDELFRFAFESVGFLLFDKRFGLVDGGED
MRPEVALFAKSLDGFLRNIVGVSDLPLWFYKLYETRTYKDVMR
SLDGMYHCANVFVDERIKEMEQE
EICKDFEKDVTRLDFFTFLLLRGN
LKKEDLLASVIDLIFAGSDTTANTFQWALYLMGKN
PKKQEKLHKEVRSVLGANDCPTSQHISNMPYVTAWLK
ETLRMYGTVPFVTRKLPVEITLQGYKIPAW
TSFVILTSVISRD
KDNFDEPLVFRPERWLRDDTGQKRETF
NALASLPFGFGKRMCVGRRIAELELRILLAK
TTLKFKVAYPHEDRIEPFMRA
TLIPDLPLRVSFIDRKH
CYP375B1 Nematostella vectensis (starlet sea anemone, Cnidarian)
JGI protein ID:102678
51% to CYP375C1, 49% to CYP375A1
41% to CYP375D1, 39% to Lottia gigantea CYP371C1
ETYGKIFKF
DV
PGGFKIISVADPDTAMAILRNEPKYPKRFDIPLIDFYR
ETRKKIPGVFFAEGSDWHKYRSVISKRIL
RPKEVADYVPEFDNIGSKFLERVEYIRGKAGT
DSEYEVENLDNELFKWSFESVAYMLFDKRFGTLEEN
VNPDVQAFIASVGGLLENFLPATLLPVFVYKVYETEAYKNFVY
HFDTMYEYAEKFIGERVQELEKE
GKLDGDIQDGERVDFFRFLLSSGK
LTRDDLLASVIDLLFAGVDTTSNTMQWVFYTMGKH
QDKQEKLYQEIISVLQPGELPSTKHIAKMPYLRAWLK
ETLRLYPVFPVLPRQVPEDIVIDGYHIPAH
TNFNILFYYMGRD
ESNFKDPLQFKPERWLRDESHSTAEAM
HAFASIPFGFGTRMCVGRRIAELEMHLLMIK
ALQRYIITYPHNDEIKPFMRG
ITKPDRPARVRFTDRPGASS
CYP375C1 Nematostella vectensis (starlet sea anemone, Cnidarian)
JGI protein ID:83609
51% to CYP375B1
VVSISDPDDVQMVLRSESKFPKRSLLPLIDQ
YRQLRQVPPGLAFAVGEEWYKHRTVLSKKML
RPPEVAAYCPTFDAITNEFLIKIHKLRGPANSPKEYE
VHDLENELFRWSFENISTVLFDKRFGCLDDH
VDPDAQAFIDAVGDFFSCISSLLLIPQWFHKIYETPTYKRFIQ
SMDTMYEYTGALVEEKKIELM
KTELESSEDKPDFFRFLLSSGK
LTENDLLASVIDLLFAGVDTTSNTMLWVLYMMSQN
PTEQQKLHHEVSTVLKPGEPITVNTLSSLPYLKAWIK
ETLRMYPIIAVLPRRMEQDLILRGYHVPAG
TTAFIHQGFMGRD
EALFPHPNSFRPERWLRGEAPLEDRVKN
TFASIPFGFGRRMCVGRRLAGQEVHVLTAR
IAQRYEVTYPEGEEEVEPTMIL
LTVPDRPLRVKFNER
CYP375D1 Nematostella vectensis (starlet sea anemone, Cnidarian)
JGI protein ID:140839
36% to human CYP27A1
KVKSYKEIPGPG
WKGNLSYFGKNGIEHMHL
RQQKWRQNHGPIYR
EQFGPYKTAFVADPKLVREVFQNEGKYPQREPQIEL
WMDYKEKRKQAHGVFSLNGEEWLKARSVLNKKML
KPKVVHGYAPELSNVVDDFIGRVNELRSTTSDKTVPN
LQNVLFKWSMESIGTVLYEKQFGAFSKS
GSEESQSIITAIQNLFSVFIKMVFMPVWVTKFYETKAVKMFYQ
SMDTLYDFTDKCVEEKLKEI
NERNVDADENSEAEFLTFLVASKS
LSLSEITSNLVEILMAAVDTTSNTSLWACYCLAKN
PEVQEKLHKEVTSVLEPGEVATLATLNKMRYLRSVIK
ETLRLYPAAPENARFMQKDTEIGGYLIPQG
TMVRIPLYVMGRD
PEIFDDPLTFSPERWMRGDDTHPDY
HAYAMLPFGHGTRMCLGRRVAELEMQLLLSR
VSQLYLLESKNDVKSIVRG
LLSPDRDVILAFNDT
CYP376A1 Capitella capitata (Gallery worm, polychaete worm, annelid)
JGI Protein ID:117101
37% to human CYP27A1
MKYAHWYTYD
AFKKYGSVFH
IKFPALNMIWLNDVPAIERLLRLDGKYPARIMVQSWKE
WRELNDKELGVLTVNGPTWKRQRRVLDKKML
RPNQVKLYTDNFNLVVTDFVDRLKYLRNKNQDGV
IEKIDVELFNWSLEMIGTVLYETRFGGLQDS
RSEEMQKFIRAVESIFRTTGTLFMLPRKLNKVFAYSNLKEHDE
AWKTIFTTGKKYIDKKV
MEIDEKIEKGEEIDGFLANLVLHKD
MSRGEIYSSTAELMMAAVDTTSNTMQWVIEMLARN
PDIQKKLHQEVSSVVGKDQVLSNSDIQNLPYLKAIIK
EVLRMYPVAGTITRILSEETAIQGYLVPAD
TTVLVGVFQICRD
PDIFPEPNVFKPERWLRDDSDVKKRI
HNFAWLPFGFGTRMCLGRRVAELELQLLTAR
LSQMFEIHPADEKPLEVVQIG
LLKPDRPVSVKLVDRN
CYP376B1 Helobdella robusta (leech, annelid worm)
JGI Protein ID:117142
39% to CYP376A1
MTVSSSTNIRSNDDTKPKIVKPFSEVPGPFQ
LPFLGNVQLLPSYIFDQEKSNE
ILLERIQKYGNIFK
EQIGNVSMVYIHDPVDIEIVYRNEGKYPRRIHIDSWRQ
WRDKNNLPRGILTEDGHQWSVMRKTLDKPML
KRDYVRSYFKEFDSVLDDFMARIEKISSQNDKNLV
PHIDQELFHWSLESIGTVLYEKRLGGLSDS
KPPQTSTFIKAVQNLFASTGKLVFLPQYINKVLFRKWFNMHAK
SWQDIFDICTIKESK
KNNNNHNNGDGGGGFLAYLLETDMK
EEEVVGSLSEIMLGAVDTTSTAVQWALYELSQN
PGVQDRIIRELDGNLKDGCLRSYQDVESLSYLKAVIK
ETLRLYPLVTIASRILDKDIVLSGYQIPKN
TTFMANIFLLCRD
NRYYTDAVKFLPERWLRKSSLSSPLLPLLTTASQV
HNFTWLPFGFGPRGCIGRRISELEMYMLLAK
LLKKYEIKCLNERKIEPLTVG
FLTPMMNE
CYP377A1 Nematostella vectensis (starlet sea anemone, Cnidarian)
JGI protein ID:162389
36% to CYP10A3
MSE
KDGFKKMFRVQKKLF
DEYGPIYK
ENLFGRTSVNILYPAESEKVFRAEGKYPSRPYVKA
WKKYREDRGIHAGIAQTEGKEWKRVRQALAPKMM
RPRELHDNIENFYEVVDDAMSRLQNARQGRTEGEVD
NLEEHLFYWATESIGTMAFDTRIGLYEDP
PKEDPKRFIECVHEFFEMTQNLELSMEKSFFEFMDTPSYKKFCR
AQDDVMRIGQKYIDMKMVELE
EMAKSPEEMLEEKAVPILTYMLAKKE
LSPHEINISAIEMFMAGVDTTSNTMVWLLYNLARN
PDAQEKLYQEINSVIGKDGYLTVSDLGKIPYTRAALR
ESMRLNPVIFMNVRQLNKDIVLSGYHVPAG
TLIQMPIYSACYS
EQLFHNPTEYKPDRWLRDGGDDI
HAFAHLPFGFGPRMCLGRRVAELEIFLFLSK
LVQKYRFDYHHEPVMKL
LMLPERPVKINFIERKN
CYP378A1 Lottia gigantea (owl limpet)
JGI Protein ID:152935
30% to CYP302, 32% to 362B1
MKSVRKVLERGCQFITKHS
YSESAVLQDVRVTSRLPAVSEPYVKPTTRKERSMGDIPGPSS
LPLIGALWQYLPGGRFYGVDFNE
SVKSLQKMYGDVVR
EDIVPGFTVIRLFNPDHFLDIRQAEGELPARAMFGMLRRYNE
LYNQNVQGLLTSQGIEWQQMRREVQQKIS
SPQAVRSFVKSQMSVAEEFLDRMDGLRDRDGT
VNDFLPEIYRYVTEAIGVVCFDGRLGVLNA
NDRDGQNFIKAVNTSLSLIYKELFTPPLYKLVTTPMFKQYCE
NMDTIRGLS
EKHINNALKHPMTDGRMNLIQQLSYQSK
LTYRQIFTFLSELFFGGVDTTGHCLVFSLHALSRY
PEVQEKLYNEIKDYSSSDICNGALDSSSYLRAFLK
ESLRMFPIAPGLGRTTSKDTTTAGYHIPSG
TNIVLHYDMAGKD
ERFVPNPTEFIPERWIRPIPTYI
SPYVTVPFGFGPRSCPARRTALQEVSLILIK
ILQKYKIEATTEDLPIKMQL
LNCPSKPVSYTFIERET
CYP379A1X Epiphyas postvittana (Light brown apple moth)
ESTs EV809285.1, EV808377.1
Renamed CYP405A1 due to a name conflict
TSEGERWKSTRKLMTPSFHFKTLEARVETVNSRMGALNQVLDQYVDKAPVDLYRYLRPFM
FDILCNTLMGVDHNMLANPDHPYLDASGRIIKIATENYFSYWRNISFIFKLTPIYKEMMD
TIKTVRGYSDKLIRERRVKLNKIIDDIKSNNRDASVDVKAFVHEKVSEQACLLDSLLLST
LPNGDPAPDETINEEITLLCFTGHYTTTMTMTHTLYCLAKYPEIQKRVLEEQESIFNNDK
LRNPTNHDLIEMKYLEAVIKESIRVIPTVTKIGRQLQNELPLKDGRIIPPGTQVVVYYEA
LYADPKVFPEPEKYNPERFFNSMHPYAFVPFSAGPRNCIGFRYAWVAMKASLSNLLRRYE
VLPGNPEDEPKFAHRIITESTNGVKLRLKKRE
CYP379A1 Carcinus maenas (green shore crab)
FJ266093
ESTs DY657564.1, DN796669.1, DY308678.1, DN796206.1,
Kim Rewitz
Sequence 1
41% to 2L1, 38% to 2N2 Fundulus AF090435, 34% to 18A1 Daphnia,
35% to 2E1 human, 49% to CYP379B1, 48% to CYP379B2, 47% to CYP379B6,
53% to CYP379B5 C-term,
50% to CYP379B3, 53% to CYP379B7 C-term, 50% to CYP379B4
MLVELVLFGGVLFLLWKVLSKPAGLPPGKWGLPLVGYIPWTNKNFEEVVMDLHKQYGDIFLWRMGNQLLV
FLNDYKMVKEAFSRPEFTVRPDWETFKTYEETPRGISTTHGVMWHNNRRFTLRQLRDLGMGKSSLVEAVQ
QQCLKLRDSIAKDAGTTVAIPLQLHVTVLNIIWHMVASKQFDAEDKRLQEFVHLMEEFVILSNRTALQDF
LPWLESIMPDFLFKRLLKYHEVIDVKEKFICYFQEEIKEHIATLDPDNPRDLIDSYLVEMEAKKDDPETT
YSEWDLVFILFDMFFAGSETTVNTFTWLCCYLAANPQAQLKLQAEIDEVLPNGALPTLMEKSRMPYTEAV
INEVMRVCALVNFGLQHMAANNTTLGGYTIPKGAVLSATVTSIQYDNRYWDQPKEFKPERWLDDNGKFSM
TKEGFLPFGVGKRVCVGESLARMELFVFTTMIFQSFSISPPPGKSVNLSPDLSGFFFRKAMSNKFVFTERKH
CYP379A2X Zygaena filipendulae (zygaenid moth, Lepidoptera)
GQ915312
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-1
only 32% to Cyp4e1 Droso., 58% to CYP379A3,
53% to Light brown apple moth CYP379A1
Epiphyas postvittana EST EV809285.1
Renamed CYP405A2 due to a name conflict
CYP379A3X Zygaena filipendulae (zygaenid moth, Lepidoptera)
GQ915315
Mika Zagrobelny Larsen
Submitted to nomenclature committee Feb. 4, 2009
Clone name Zygae_P450-4
only 30% to Cyp4e3 Droso. 58% to CYP379A2
Renamed CYP405A3 due to a name conflict
CYP379B1 Petrolisthes cinctipes (crab)
FE820627.1 FE823472.1, FE806612.1, FE829403.1, FE821762.1
FE806917.1 FE823784.1 FE781035.1 FE823784.1 FE781035.1
FE782980.1, FE778648.1, FE797671.1, FE790532.1
FE783351.1, FE763716.1, FE791800.1,
Sequence 7
55% to CYP379B3, 51% to CYP379B6, 59% to CYP379B4, 49% to CYP379A1
67% to CYP379B2, 54% to CYP379B5, 50% to CYP379B7
41% to 2L1
MWVEALLLVLLFLLLKKVLRKPDGLPPGRWGLPLVG
YIPLFDKRPMLEQLQDLRKQYGDVYTWRVGTQLMIFIHDYKLIKEAYSKSEVTERPKWWF
YNVGQNPGLGISGSNGERWHNNRRFTLRQLRDLGMGKSRLVAAVHRQASMLVEEIKKQS
GQPAPIPHALNVAIINVIWQMVAGIQFEVADPEMKKFQDMMLDFFSVTDRLLIPDLMPWL
LQIMPKTLSDRIFKMDHAMGMIDKFFNYFKAVMDEHRATLDRDNPRDLIDSYLMDMDDNQ
DDPESMLHEKDLSFIIFDLFFAGSQTTADTLKFTFYYLANSPRVQSKLQAELDETLGGALA
TLEDRARLPYTEAVIQEAMRMSTLTPIGLHHIATQDLQLGGYHIPKGTVFNTMAISVHYD
PNVWEDPHQFLPERWLDDKGHFAFKREGFMAFSIGKRQCVGEALARMELLI
VLAAVMANFTITPPPGKTIDSSPDPASELFHLSRQQDIVFTHRKQ*
CYP379B2 Petrolisthes cinctipes (crab)
FE793642.1, FE765331.1, FE768218.1 (5 aa diffs), FE792515.1
Sequence 8
67% to CYP379B1, 51% to CYP379B6, 46% to CYP379B3, 48% to CYP379A1,
55% to CYP379B4
MWVEALLLVLLFLLLKKVWSKPDGLPPGRWGLPYIGSIPFFSKLTLYEHLKDLQKKHGDI
YTWRMGTEVIVFIHDYKLTKEILNRPEVSDRPDWIFFTLGDKPPLGIASTNGEIWHNNRRF
SLRQLRDLGMGKSKLVAALHKQATILVEELKKQSGQPAPVPHAVNVAVINIIWQMVASIQ
FEVTDPKMIEFQDLMTNFNKVTDRAYFHDLFSWLPQILPSALSDRLFKLDHVRNLLSMLS
VYFKKVIDEHRATLDMDNPRDLIDNYLIDLEGDEKLPVEMQNEKNLVWIILDLFFAGSQTTA
DTLRFTFYYLANNPRVQSKLHAELDEVL
CYP379B3 Petrolisthes cinctipes (crab)
FE798452.1 57% to CYP379B5, 65% to CYP379B7, 66% to CYP379B4,
50% to CYP379A1
Opp end FE798453
FE774456.1, FE809818.1 opp end = FE809817 = N-term
FE766093.1 opp end = FE766092 = N=term
51% to CYP379B1, 53% to CYP379B2, 54% to CYP379B6, 47% to CYP379A1
Sequence 5
MIVEALLWGALLLLLWLSFKKPQGLPPGRWGLPLLGYIPLTT
KPLSQQLTDLRNKHGDIYIWRMGTQLMVFLHDHNLIREAFNRPEMQDRPEWKSFRFNIKE
KLGVIASNGHVWLTNRRFTLKQLRDLGMGKSKLVEAVHTQTRLLLEEFKKQAGGKPMPVP
HALNIAITNIVWQMVAGKQFTLDDPRMREFEAMTDDLVSSFGLAAAPDFLPWAQVLI
(31 aa gap)
KETLDPYNPRDLIDAYLMEIEERKDQPDNTFKEKDLFSLILDLFFAGKETTAASLVWLIYYL
ATYTEAQRKMQAEVDEVL
PKGTLATLQDKARLPYTEAVIHETLRVSSLSAMGVSHAASKDTMLGGYVIPKGAIINSSN
ITIHHSSRYWDEPHLFKPERWLDNDGKFNTKKEGFMPFSIGKRQCVGEGLARMEMLIMSS
ALMQNFTITIPPGATLSLESVPGNPFF
SVPGNPFFRRFITQNLIVTARN*
CYP379B4 Petrolisthes cinctipes (crab)
FE829509.1
Sequence 6
66% to CYP379B3, 59% to CYP379B1, 54% to CYP379B6, 50% to CYP379A1,
55% to CYP379B2
MIVEALLCVSLLVLLYLSLRKPPGLPPGRWGLPLVG
YVPSTTRSIPQQLADLRNKHGDIYMWRIGTQIQVFLHDHQLIKEAFTRPEFQDRVDFKGF
RFMDPNKLGLAQSNGEHWHNNRRFTLRQLRDLGMGKSKLVSAVQSQSSLLVQEFKKQAG
RPAPIPNTLSLAIINVIWHMVSGKEFSLTDP
CYP379B5 Petrolisthes cinctipes (crab)
FE812260.1 CCAG30364.b1, FE839854.1 CCAG48763.b1, FE795110.1
opp. End = FE795111 (non-coding)
54% to CYP379A1, 54% to CYP379B1, 57% to CYP379B3, 57% to CYP379B7
Sequence 4
IRDKFLLYFKEVVEEHRATLDPNNPRDLIDGYLMEMEERKEDLDSTFNEADMYMLILDLF
GAGTSTTTDTITFILQYLAVYPKVQRKLQDEVDRVLRGRLLTLEDRSRLPYTEAVIHEV
LRKSSLASIGVQHVATKDTFLAEYVIPKGTVIHSVAVSIHHDPRYWEEPHVFKPERWIDH
QGHFTATKEGFLPFGVGKRQCVGEGLARMELFIFTVAVFQSLNLAPPPGST
INPTHDPNIPIAHMPTNQPIHITSREPVEVA*
CYP379B6 Carcinus maenas (green Shore Crab)
DY656036.1,
DY307501.1, DY656714.1, DW249163.1, DN634739.1,
DY657052.1, DY308481.1, DV944423.1, DY307476.1,
DN635373.1, DY656037.1, DV642767.1 (extends)
46% to CYP379A1, 51% to CYP379B1
Sequence 2
MWVEVVLGAALIFLLWQVLK
KPSDLPPGRWGLPLVGYLPLPFKSLEDHLRELHEKHGNIYIWRMGGHIMVFLHDQKMVRE
AFTSTDFIDRPPFMIFCLNEKSPKGVVGSNGLLWHNNRRFALRQLRDLGMGKSKLVAAVH
TQAAMMVEEFKKQAGRPAPIPHAMSVAVVNIVWQMIGNIQFKTTDPKFVEFRELIESLMD
SMKRLAILDIFPWINDILPRPIVNWICRLDIVDRAKDKFFTYFKEVIDDHKNTLDRDNPRDLID
AYLIEMEKGDPDSTCTDRDLCFLIFDLFNAGSLTTRDTTIWMIYYLANHPRV
CYP379B7 Homarus americanus (lobster)
CN951709.1,
59% to CYP379B8 Litopenaeus vannamei
65% to CYP379B3, 57% to CYP379B5
Sequence 3
PDNTFSEKDLAILVLDLFLAGSETTTNTLTWLFYYLATYPEVQQKMQAEIDEILPKGTLA
TLDDKLRMPYTEAVIHETLRKSSLAATGVQHVATRDTQLGGYYIPKGTIVMGAQETVHHD
LRYWDRPDKFLPERWLDQQGKFTTKKEGFLPFGVGKRSCLGEALARMELFIFSTTVFQSL
TFSQPPGKRIDLRYETKAIFTHNPKNSDVL
CYP379B8 Litopenaeus vannamei
EST FE129632.1
59% to 379B7, short, may need to be renamed
sequence 9
TVYPKGTIITSAFFHIHFD
PRHWEQAEKFMPERWLDQEGKFNGKRDGFVPFGIGRRSCLG
ETLARMELFIFSTAVFQSLNVAPPPGTALDLAHDDNQPFFHNAKTQDVYVTVR*
CYP380A1 Acyrthosiphon pisum (pea aphid)
LOC100165004 SCAFFOLD17282:20108..54426 (- strand) top half only
N-term is on SCAFFOLD11661:5770-6260 (-) strand
see EST EE264487.1 Myzus persicae to confirm N-term
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP4 clan
MYGKLSLPELIIYASVALILALWFHWRWKHRYFLDLAEKLPGPPCYPLIGTTSMYTSTYD
ETIAKLKENAEKYNYEPVGTWIGPIHYVSVVKPEDIQ
IVLNNSRALEKGQLYSF
LKSLLGEGLLTASVDRWRKHRRIISYAFNVKFLEQLYPVFNEKNKTLIKNLRKNINSTQP
FDLWDYIISTTFDTICQTAMDYRINEKKKKRPPR
MFGKLSSPELIIYTFVALILALWFHWRWKHRYFLDLAEKLPGPPSYPLIGTTSMFTHTYD (1)
ETIAKLKENAEQYNYEPVGTWIGPIHYVSVVKPEDIQ (0)
IVLNNSRALEKGQLYSFLKSLLGEGLLTASVDRWRKHRRIISYAFNVKFLEQLYPVFNEKNKILVKNLRKNINSTQPFDLWDYIISTTFDTICQTA MDYRINEKHNKTEFLDLMTTIANQLVKTVNRPYLYPSLFFSIYRSMSGLGEKLELINKLPLQLIDEKKIDFRSKIVESDSYPEEFTNEKKNKFKTFIDTLLEASENDPDFTNADIRDEVITMMFAGSDTNATTECFCLLLLAIHQDIQDEVYDEIYNVVRDSDRELTPEDTANFSYLEQVIKETLRMYPTISVFTRQLVEDVKVTNYVLPRGASVTISPIVTHHCPHLYPNPEAFNPDNFSIENVAKRHKYSYIAFSGGPRGCIGMKYAMISMKLMITEILRNFSVHTDIKLSDVRIKMNDAFTRKVGGYPITIRPRDRRPSYVRRNTRVA
CYP380A2P Acyrthosiphon pisum (pea aphid)
LOC100167018.pro SCAFFOLD17282:20108..54426 (- strand)
bottom half only
pseudogene
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
55% to CYP380A1
CYP4 clan
VIKEKKAEFDQRLKATNDKVDVTNNDDEKYSKLFLDILFELNNNGGNFSDSDIRDEVVTMMT ()
GGSETSAITICFCLLMLAIDQDIQ
DKVYDEVYDIFGESDHIITIEDTTRLVYLEQVLKETLRLYPVGPVLLREIREDLKI ()
FSNDYVLPKGTTCVISPIATHHSPDLYPNPWSINPENFSPENVAKRHKYSFIPFSGGPRGCI ()
GSKYAMMSMKVTVSTFLRHFSVHTDIKLTDIKLKIDLLMRSVHGYPVTIRPRDKRPTYYNMRNQNKQG
CYP380B1 Acyrthosiphon pisum (pea aphid)
LOC100161319 SCAFFOLD11137:17306..28967 (+ strand)
SCAFFOLD11137:AUG4_SCAFFOLD11137.g1.t1 = LOC100161319
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
39% to CYP4G14 C-term half
52% to LOC100165004, 50% to LOC100167889
CYP4 clan
MFAQMRMAIHNAAHALPMTKSELYFYASIVIFVVLWCRMRWQYRQFYRLADKLKGPPSYP LKGSIFDLSTTPEKLMYNFKESAEKYNYEPVKLWVGPFFFVGVYKPEDVQIVLNSSKALE KGMIYHIIRHAVGEGVFTAPMGKWKKHRRVIASIFSSKFLDQLYPIFNENNKKLVENISK HVGETQPFDIWDYIISCNLNNVSQAA
MGYNLNDQRTLSEFVLAMKKVSELSKCIVKPWLY IDQIFAVYTYLTGLNVYMSQLNRVSLQIIRDKKLEFKSIKLQQSTDKSHEVVPEKKRNST KVFLDKLLKLNDEGADFTDEDLKDEVITMTVAGSDTSAISECFCILLLAMHQDIQDKVYD EIYSVLGDSDREVIPEDIFRFKYLEMVLKESLRLFPPGAIFSRKINENVKLTNFELPKGS NVFVSPYVTHRCPQLYPNPDTFNPENFSAENEANRHKFSFLAFSGGPRGCLGVKYAMISM KLMMVAVLRRYSVHTDCKLSEIEMQIDLLAKKANGYPITIRPRERTQDR
CYP380C1 Acyrthosiphon pisum (pea aphid)
LOC100162836.pro SCAFFOLD10061:3374..10265 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
small sequence gap
CYP4 clan
MIEIIVYIIVVIFIV
MWCYFKWHNRPFEKLAARMPGLPAYPFIGSLYTCIGVTSEQLRSRILDLVKDYNLGPIKCWMGPYFGVFIVRPEDIQIVLNSSNALQKGFVYNFFKVILGEGLFTAPIDKWRIHRRMISPFFNGKLLEQFFPVFIEKNRILIRNVAKQLNETQVFDLWDYIAPFAFDTICQNTLGYNIDTQTNKNECEFAKAIVKTLDLEGMRIYKPWLYPEFVFSMYLKLTGQQRVFETVRKFPLQVIKEKKAEFDQRKKLIDAKIDVTNSNEHQSKLFLDTLFELNNGGGNFSDSDIRDEVITMLAA
XXXXXXXXXXXXXXXXXXXXXXX
DKVYDEIYDILDDSDHMISIEDTTRLVYLEQVLNETLRLFPAGPMQLKEIQEDLKISSSDYVLPKGTMCVISPLVTHISPDLYSNPRDFNPENFSPENIAKRHRYSFIPFSGGPRGCIGSKYVMMIMKVTVSTFLRHFSVHTNIKLTDIKLKLDVLMRSVDGYPVTIQPRHKRPTYKRNKKPLR
CYP380C2 Acyrthosiphon pisum (pea aphid)
LOC100160808 SCAFFOLD10061:16344..23495 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
49% to CYP380A1
CYP4 clan
MIEIIVVIFVM
MWCYIKWHNRPFEKLAARMPGFPAYPFIGTGFQFIGLTPEQIMNRILDYEKDYNLEPFKIWIGPYFGVFIVKPEDLQIVLNSSKALQKGCVYDFFKHVTGEGLFTAPVDKWRIHRRMISPLFNGKLLEQFFPVFIEKNRILIRNVANQLNETQVFDLWDYIAPFALDTICQNTLGYNLDTQTNKNGCEFAEAIVTTTDLEGMRIYKPWLYPEIVFSMYLKLTGQQRVFETVRKFPLQVIKEKKAEFDQRKKLIDAKIDVTNNNEHQSKLFLDTLFELNNDGGNFSDSDIRDEVVTMLTGGSETSAITVCFCLLMLAIHQDIQDKVYDEIYDIFDESDHMISIEDTTRLVYLEQVLKETLRLFSVGPLLLREIQEDLKIFSSDYVLPKGTTCVLAPIGTHLSPNLYSNPRDFNPENFSPENIAKRHRYSFIPFSGGPRGCIGSKYAMMSMKVTVSTFLRNFRVYTDIKLTDIKLKLGLLMRSVDGYPVTIRLRDKRPTYKRNKKPPR
CYP380C3 Acyrthosiphon pisum (pea aphid)
LOC100158738.pro SCAFFOLD10061:35318..41755 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP4 clan
MIEIIVYIIVIIFVVTWCYFKWHNRPFEKLASR
MPGPPAYPFIGTLYQFIGLTSEQIVSRILDYVKDYNLEPFKFWMGPYFGVVIVKPEDLQIVLNSSKALQKGYVYDFFKDIGGEGLFTAPVDKWRIHRRMISPLFNGKLLAQFFPAFIEKNQILIRNVAKQLNETQVFDLWDYIAPFALDTICQNTMGYNLDTQTNKNECEFAEAI
(seq gap)
VIKEKKAEFDQRKKLNDAKMDVTNSNEHQSKLFLDTLFELNNGGGNFSDSDIRDEVITMLIAGSETSAITVRFCLLMLAIHQDIQDKVYDEIYDIFDESDHMISIEDTTRLVYLEQVLKETLRLFSVGPLLLREIQEDLKIYDDYVLPKGTMCIISSIATHHSPDLYPNPWSFNPENFSPENVVKRHKYSFIPFSSGPRGCIGSKYAMMSMKVTVSTFLRHFSVHTDIKLTDIKLKLGLLMKSVNGYPVTIRPRDKRPTYKRNLKPLR
CYP380C4 Acyrthosiphon pisum (pea aphid)
LOC100159590 SCAFFOLD17803:1..16255 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
missing C-term in a seq gap
CYP4 clan
MIEIIVYIIVVIFVVMWCYFKWHNRPFEKLAARMPGPPAYPFIGTLYGCIGLTSGQIVSRILDYVKDYNLEPFKFWMGPYFGVFIVKPEDLQIVLNSSNAFQKGFVYDFFKVILGEGLFTAPVDKWRIHRRMISPFFNGKLLEQFFPVFIEKNRILIRNVGKQLNETQVFNLWDYVAPFALDVICENTMGYNLDTQTNKNECEFAKAIVIKEKKAEFDQRKKLNDAKMDVTNSNEHQSKLFLDTLFELNNGGGNFSDSDIRDEVITMLAAGSETNAITVCFCLLLLAIHQDIQDKVYDEIYDIFDESDHMISIEDTSRLVYLEQVLKETLRLLPAAPFLLREIQEDLKIFSSDYVLPKGTMCIISPLATHRSPDLYSNPRDFNPENFSPENIAKRHRYSFIPFSGGPRGCI
CYP380C5v1 Acyrthosiphon pisum (pea aphid)
LOC100162710.pro SCAFFOLD12542:91226..95809 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
runs off the end of the contig
& = frameshift
74% to CYP380C2 LOC100160808
CYP4 clan
MIEIIAYIIGIVLVMVWCYFKWQNRRFEKLAAIMPGPPAYPIIGIGYTFFGSSEHVMSKIIDLVKEYNLSPIKLWLGPYFAVSISKPEDLQIILNNSKALQKDRMYDFFKYAVGEGLFTAPVDKWKRHRRMITPAFNAKLFEQFFPVFNEKNKILIKNVTKELNKTQMFDLWHYVAPAALDTICQTTMGYNLDTQSNNKECEFGEAIVM (2)
ASEVAAMRIYKPWIYPEMVFSMYLKLTGHQRVFETVK &
KFPLQVIKEKKDEFDQRKKAINAKVDLANNKDENQSKLFLDILFELNNTGGNFSDSDIRDEVVTMMTGGSETSAITICFCLLMLAIHQDIQDKVYDEIYDIFGGSEETITIEDTTKLVYLEQVLKETLRLYPVRPVLLRELQDDVKIFSNDYVLPKGTTCVLCPITTHHCPVIYPNPWSFNPENFTPENVAKRHRYSFIPFSGGPRGCIGSKYAMLSMKVTVSTFLRHFS
VHTDI
CYP380C5v2 Acyrthosiphon pisum (pea aphid)
aLOC100167486 SCAFFOLD4690:1..2605 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
runs off the end of the contig
96% to CYP380C5v1
CYP4 clan
MIEQIAYIIGIVLVWSYFKWQNRRFEKLAAIMPGPTAYPIIGIGYKFFGSSEDVMSKIIDLVKEYNLSPIKLWLGPYFAVSISKPEDLQIILNNSKALQKDQMYDFFKYAVGEGLFTAPVDKWKRHRRMITPAFNAKLFEQFFPVFNEKNKILIKNVTKELNKTQMFDLWHYVAPAALDTICQTTMGYNLDTQSNNKECEFGEAIVM
ASEVAALRIYKPWLYPEMVFSMYLKLTGHQRVFETVKKFPLQ
CYP380C6 Acyrthosiphon pisum (pea aphid)
LOC100167889 SCAFFOLD12103:1756..16564 (+ strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
49% to LOC100165004
CYP4 clan
MEVSQDFPVSSLKHSAGGPRMTSTELTAYGVISFIVVLWCHYKWNRRHFERLASKMTGPPAYPIIGAGLEFVGTPQQVIERIIKLFDIYGSEPFKVWMGTSLGVTISKPEDVQIVLNSSKALEKDQFYKFFKNTVGEGLFSAPVHKWRRHRRLITPVFNANLLDQFFPVFNEKNRILTRNLKKELGKTQPFDLWDYIADTTLDIICQTAMGYNLDTQLNNESEFAEALTKASELDSMRIYKPWLHPDIIFSIYGKLTGLHNVYKTLHKLPNQVIKEMKETYAQRKIDNKSNTIDVNDDDKKRLKVFLDTLLDLNEAGANFSDEELRDEVVTMMIGGSETSAITLCFCLLLLAIHPEIQDKVYDEIYEVLGDGDQTITIEDTTKLVYLEQCLRETLRLYPIGPLLLRQLQDDVKIFSGDHTLPKGTTCIISPICTHHIPELYPNPWSFNPDNFDAENVSKRHKFSFIAFSGGPRGCIGSKYAMLSMKVLVSTFLRNYSVHTNVKLSDIKLKLDLLMRSANGYPVTIRPRDRRPTYKKNTHCSTVNL
CYP380C7 Acyrthosiphon pisum (pea aphid)
LOC100168315 SCAFFOLD2534:44976..48195 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP4 clan
MENIIQSVRDFRLTTSEVIVYQLIVCFVVIWCQFKWIRRNFESVAAKMKGPKGYPFIGSSFDFIGTPEQVMEKVLKIDDKYSPGPIKIWVGPYFGVIVIKPEDVQAVLNNSKALQKDRVYDFIKNIFGEGLLTAPVHKWRKHRRLITPSFNASLLNQFFPVFNEKNKILIRNLKKELGKTTPFDLWDYIAPTTLNLICQTAMGYNLDTQSEYGTEFENAMIKASELDSLRMKTPWLYLSFMFKLYLKLKGHSDVFNTLYKLPIKMIQEKKEAFAQRKILNKPSAVDVTDNEREKLKVFLDTLFELNEAGANFSDDDIKDEVVTMMIGGSETSAITICFSLLMLAIHPDIQDKVYDEIYEVFHDDNETITIEDTNKLVYLEQVLKETLRLFPVLPLVFRKLEDDIKIASDDLVLPKGTTCIISILGTHHFSESYPNPWTFNPENFNPENITNRHKYSFIAFSGGPRGCIGSKYAMMSMKVAMSTFLRNYSVHTHYTFDDIKLKIDLLLRSANGYPVTIQLRDRRPTYIRNKKL
CYP380C8 Acyrthosiphon pisum (pea aphid)
LOC100165148p SCAFFOLD1571:20813..37353 (-strand)
also SCAFFOLD17147:5399..9863 (- strand) C-term
see EST ES224491.1 Myzus persicae for N-term match
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
CYP4 clan
VLLLLNARYCRIEATMQSVSGFRLTITEVFA
YTIICTLAILWCRFKWNRRHLDRLAAGLE
GPPAYPIIGSALQFIGTPEEVLNNLVQLIEDYCPGPFKIWMGPYFGVAIVKPEDLQIVLN
SSRTLQKDRFYNFIKNIFGEGLLTAPVDKWRKHRRLITPSFNSILLNEFFPV
YPTICFVVI
LWCRYKWNRRHLDKLAAGLKGPPAYPIIGSALQFIGTPEEPNLFQIVLNSSRALQKDRFYNFVKNIFGEGLLTAPVDKWRKHRRLITPSFNSILLNEFFPVYNEKSKMLIRNLKSELNKTQPFDLWDYIAPITLNLICQNAMGYNLDSQSKSGSEFEKAMIKASELDSIRVSKPWLYPSIMFSLYLKLKGYSNVFNSLYKLPLKMIHKKREEFAQKKIGNESNYLDVTDNERKHSKVFLDTLFELNEAGANFSYDDIRDEVVTMMIGGSETNAITLCFCVLLLAIYPSIQDKVYDEIYDVLGDGDQTITIEDTSKLLYLDQVLKETLRLFPVIPLILRQLQGDVKIISNNIVLPKGSTCYLSPLATHRDSDSYPNPTSFDPENFSPENIAKRHKYSFIGFSGGPRGCIGSKYAMLSMKVLVATFLRNYSVHTDCKFNDIKLRLDLLLRSSNGYPVTIRTRDRRP
VYKFKLEYI
CYP380C9 Acyrthosiphon pisum (pea aphid)
LOC100162179 SCAFFOLD17731:37803..45605 (- strand)
Genome set of sequences submitted by Rene Feyereisen Aug. 6, 2009
N-term may be too long
CYP4 clan
MGLGDYVQLYNALETGAII
MQSVGEFRLAVSEVLLYSAIISVVVFWCSCKWNNRHINKLDSKMKGPPAYPIIGSALELLGTPELDKWRKHRRLITPLFNANLLSQFFPVFNEKNKILIRNLKKELGKTQPFDLWDYIAPTTLNLICQNAMGYNLDSHSQCGSEFEKAMIKASELDSIRIYKPWLFPNIFFSLFLRLQGQSNVFKTLKKLPLKMINEKKEVFAQKKIVKETIVMNNTDGEKKNLKVFLDTLFELNETGANFSDNDILDEVVTMMIGGSETSAITLCFSLLLLAIHPDIQNKVYDEIYDVLGDGDQTITTEDTIKLVYLEQVLKETLRLFPVLPLVIRKLQDDVKIISGNHLLPKGTTCYIAPLFTHRDCDSYPNPLNFNPENFSQENISKRHKYSFIAFSGGPRGCIGSKYAMLSMKVMMSMFLRNYSVHTNCKFNDIKLKLDLLLRSANGYPVFIQSRDRRPSYKLNKT
CYP380C10 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf4
62% to CYP380C5 aphid
CYP380C11 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
N-term, incomplete
CYP380D1 Trialeurodes vaporariourum (whitefly)
CYP380E1 Trialeurodes vaporariourum (whitefly)
CYP381A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP381A2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP382A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP383A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP384A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385B1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385C1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385C2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385C3 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385C4 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385C5 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP385C6 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP386A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP387A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP387A2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP388A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389B1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C3 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C4 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C5 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C6 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C7 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C8 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C9 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C10P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C11 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C12 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP389C13 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP390A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP390B1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP391A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A3P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A4 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A5 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A6 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A7 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A8 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A9 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A10 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A11 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A12 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A13 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A14 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A15 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A16 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A17 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A18 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A19 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A20 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A21 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392B1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392A1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392B2P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392B3P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392B4 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392B5 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392C1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D3 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D4 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D5P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D6 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D7 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D8 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D9P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392D10P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E1 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E2 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E3 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E4P Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E5 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E6 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E7 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E8 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E9 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E10 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP392E11 Tetranychus urticae (two-spotted spider mite, arachnid)
CYP393A1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee Oct. 21, 2009
Very poor match
clone name DPO047_M16
CYP393A2 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
82% to CYP393A1 Dendroctonus ponderosae
CYP394A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig4030 575aa 26% TO CYP49A1,
29% to CYP334B1, in the mito clan
This seq has a damaged Heme signature,
no conserved CYS (possible frameshifted region)
CYP395A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig20452 454aa, in the CYP3 clan
35% TO CYP6A14, 91% to contig18794, 90% to contig18793,
90% to contig22097, 70% to contig22737
70% to contig22006, 69% to contig1426, 68% to contig7981
34% to CYP6CE1, 37% to CYP6M3
CYP395A2 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig18794 505aa
35% TO CYP6A14, in the CYP3 clan
CYP395A3 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig18793 505aa
36% TO CYP6A14, in the CYP3 clan
CYP395A4 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig22097 506aa
35% TO CYP6A14, in the CYP3 clan
CYP395A5 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig22737_20384 516aa
35% TO CYP6A14, in the CYP3 clan
CYP395A6 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig22006 505aa
35% TO CYP6A14, in the CYP3 clan
CYP395A7 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig1426 516aa
36% TO CYP6A14, in the CYP3 clan
CYP395A8 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig7981 516aa
34% TO CYP6A14, in the CYP3 clan
CYP395B1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig5015 512aa
33% TO CYP6D5, 35% to CYP6AX1, in the CYP3 clan
CYP396A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig13956 510aa 34% TO CYP6A21,
33% TO CYP6BQ13 Tribolium, in the CYP3 clan
CYP397A1v1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig19527 458aa
26% TO CYP9J, 31% to 347A4, 31% to 9Q2, in the CYP3 clan
CYP397A1v2 Cimex lectularius (bedbug)
No accession number
Praveen Mamidala
Submitted to nomenclature committee June 9, 2011
6 amino acid diffs to CYP397A1v1.
CYP398A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig2453 493aa
33% TO CYP6AG3, in the CYP3 clan
CYP399A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig5575 509aa
31% TO CYP6A17, 33% to CYP6N5, in the CYP3 clan
CYP400A1 Cimex lectularius (bedbug)
No accession number
Zach N. Adelman
Submitted to nomenclature committee Dec. 1, 2009
contig8295 315aa
34% to CYP345D1, 33% to CYP6J1, in the CYP3 clan
CYP401A1 whitefly Trialeurodes vaporariorum
Confidential
CYP402A1 whitefly Trialeurodes vaporariorum
Confidential
CYP402B1v1 whitefly Trialeurodes vaporariorum
Confidential
CYP402C1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
39% to CYP402B1v1 Trialeurodes vaporariourum (whitefly)
CYP402C2 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
71% to CYP402C1 Bemisia tabaci
CYP402D1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
45% to CYP402C1 Bemisia tabaci
CYP403A1 whitefly Trialeurodes vaporariorum
Confidential
CYP403A2 whitefly Trialeurodes vaporariorum
Confidential
CYP404A1 whitefly Trialeurodes vaporariorum
Confidential
CYP404A2 Laodephgax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
57% to CYP404A1 whitefly Trialeurodes vaporariorum
CYP404A2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
N-term, incomplete, 57% to CYP404A1 whitefly Trialeurodes vaporariorum
CYP404B1 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf18
49% to CYP404A1 whitefly Trialeurodes vaporariorum
CYP404B2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
incomplete, 89% to CYP404B1 Sogatella furcifera
CYP405A1 old name = CYP379A1 Epiphyas postvittana (Light brown apple moth)
EST EV809285.1, EV808377.1
Had a name conflict with crab P450s
TSEGERWKSTRKLMTPSFHFKTLEARVETVNSRMGALNQVLDQYVDKAPVDLYRYLRPFM
FDILCNTLMGVDHNMLANPDHPYLDASGRIIKIATENYFSYWRNISFIFKLTPIYKEMMD
TIKTVRGYSDKLIRERRVKLNKIIDDIKSNNRDASVDVKAFVHEKVSEQACLLDSLLLST
LPNGDPAPDETINEEITLLCFTGHYTTTMTMTHTLYCLAKYPEIQKRVLEEQESIFNNDK
LRNPTNHDLIEMKYLEAVIKESIRVIPTVTKIGRQLQNELPLKDGRIIPPGTQVVVYYEA
LYADPKVFPEPEKYNPERFFNSMHPYAFVPFSAGPRNCIGFRYAWVAMKASLSNLLRRYE
VLPGNPEDEPKFAHRIITESTNGVKLRLKKRE
CYP405A2 old name = CYP379A2 Zygaena filipendulae (zygaenid moth, Lepidoptera)
GQ915312
Zygae_P450-1 only 32% to Cyp4e1 Droso., 58% to CYP379A3,
53% to Light brown apple moth CYP379A1 Epiphyas postvittana
EST EV809285.1
Had a name conflict with crab P450s
MLFPLVLVGIAVLLIIVQDYVRKSSRTWKLLNKFPGDKPLPLIGNALQIGFNSDETCAKLMQMWHRHGQQTFRVTMGFENWV
MLCEPDDIRIILSHPTELSKPLERNAAFKPFFGNSVSTAEGEKWKSTRKLIVSSFSFKTLDQRQETINKYCDQLAQIFDRYK
DKKDVDLYRYLKPFMLDLMCDSFMGVERNFLQNVEHRYFKTGKNIIKILTNNYFNHWRIIESIFVWTPMYKEMTETIKNIRD
LSQELIYSRKVKTHKNSEYIDEIEEEKKKNAAEDLCLLDKFLNSKLPNGEPVPDSQINEEISLLCFTAHYTTTVTMSHALYL
MAKYPEVQQKAYEEQMMIFGEDKLRKATNDDLGKMKYLEAVVKETFRVLPTVTKIGRQLQEDLTLSDGRVVPAGTSVVVFYE
AMNMNPKLFPEPSKFDPERFYGNPASYIVPFSAGPRGCLGSGYAWMAMKSVMSTVLRRYKLSVAKEPDIAYRMLLESDNGIN
LKLSSRV
CYP405A3 old name = CYP379A3 Zygaena filipendulae (zygaenid moth, Lepidoptera)
GQ915315
Zygae_P450-4 only 30% to Cyp4e3 Droso. 58% to CYP379A2
Had a name conflict with crab P450s
MFYSLVLSAVLLCLVLVYDLVRKSGRAWRLLEKFPGDYPLPFIGNALQIGFNTDETCKRLMDLFYKHGMQNFRVTLGMENWI
LLSDPDDVKIILSHPNELSKPIERNAAMLKFFGNSVSTSEGEKWKTTRKLMVSSFHYRSLEQKLEALNTNCDRLLNILEERR
GRGLVDMYRYLKPYMMDIVCDTFMGVDLNFLLKIQIILYFDTGRSVIALLTSNYFSHWRTIDPLFSLTQRYRDMTEAVKNIR
DVSDMLITKSKERLKEMRSSNRDEKLKKERDGLCLLDKFLLSRLPNGEPIPEEMINDEISLFCYTAHYTTTITMSHALYYIA
KYPRIQKELVDEQLNIFMDDRLRKPTLDDLNKMKYLEAVVKETLRMVPTVSKIGRQIHQDLVLSDGRIVPAGSTVLVLNKAL
HMNPALFPDPHTFYPERFCGQNKPYSSVPFSAGPRNCIGSGYAWLAMKTTLSNLLRRFQINEGIEPKFAYRMLSESRNGVQI
MLSKRHLE
CYP405A4 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee Feb. 9, 2011
54% to CYP405A1 Epiphyas postvittana
CYP405A5 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
77% to CYP405A4 Heliconius melpomene
CYP405A6 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
83% to CYP405A4 Heliconius melpomene
CYP406A1 confidential
CYP407A1 confidential
CYP408A1 Nilaparvata lugens (brown planthoppper)
GQ911996
33% to CYP358A1 Pediculus humanus corporis
53% to EST fragment Homalodisca vitripennis EG367165.1
(no Cys at heme signature)
MELQVLAIATSVLTLALAYVYR FITSKFNYFQKQGIDGPKPSFP
FGTWKGAWKKNFGEN DLNNVKTYGQTFGSFDGRTPNLIVSDPHLIQKILVDEADKFHS
NRAFRVKQKPYMKCCALLRVVVDVEVNKLLSPALNAAKVKKLFSRIAKTVDLFVEGFK
KEAAPEKVINANEHVSRFITDVLAFTLFSFDLAADNQIRTKFERAIGKMFTVQYPDSI
FSVTPFVFESLGSLDNFILKPAYTRYLAGVAELVIDEKKKTSDVKPEGRALDLVDLLL
VAAEEEKQAAAKEKGVDSDKLDSEGILSKEQMINVWMQVLLTVGGATKQTLAMSIYAL
ANNTNVQDKLQAEVGKQLNRYGEINYEFINESEYLDMFLGEILRIYPTEYRLERKTFE
EMKLDEITLTPGTMVSIPIYAVHHLEEFYPEPEKFIPERFSPSNSDKRNPHTYLPFGQ
AGSNSSNIGVQLGVLIAKLAIVSLIKSVKLATAENPQNEVSSPFVSGVTGVPQPKTIF
VRADKKEE
CYP408A2 Corn planthopper Peregrinus maidis maidis
GO428019.1
72% to CYP408A1, 42% to CYP408B1 N-term
MELHVLAVVTSILALAFAYVYRY
ITSKFNYFQKQGIVGPEPSFPFGTWKGAWKRNLGEYDLENVKTYGQMFGTFDGRTPN
LVVADPHLIQKILVDEADKFHSSRAFRVKQKTLHEVLRSIEGGGDKDVNKLLSQALYAEK
VKILFSRLAKAVDVFCGRIKKGSST
CYP408A3 Sogatella frucifera (white-backed plant hopper)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee March 25, 2011
Clone name sf16 and sf3-f
88% to CYP408A1 Nilaparvata lugens
CYP408B1 Locusta migratoria manilensis
No accession number
Enbo Ma and Yanqiong Guo
38% to CYP408A1 Nilaparvata lugens GQ911996.1
45% to EST fragment Homalodisca vitripennis EG367165.1
1 amino acid difference with ESTs CO826097, CO852058
CYP408frag Homalodisca vitripennis (syn. H. coagulata) Glassy-winged Sharpshooter
EG367165.1 EST DN198142.1
No Cys 53% to CYP408A1, 46% to CYP358A1
EYLDMFLGEILRLYPIEYRLERECVEGVKVGEAQLEPGVVVSVPIYAIHRHPDFYPDPET
FEPERFSPENAAKRDHNIYLPFGQAGTNSSNIGIRLSVLFTKLALAVLVSAFNMSAVEDA
KVPAPYQRGFTAIPKPEELWVKATVK*
CYP408frag Lepismachilis y-signata (jumping bristletail)
EST FN220044.1
37% to CYP408B1 N-term
MDALTVSLALVLIVFLLIYRF
FTANFNYFTKRGIPGPRPIPIFGTWWGSWNWILGEVDL
AWTKKYGKIFGTFDGRTPHLIISDPELVKRVLIKDFNHFRNRWLRNDAEVVRKNMVTVRD
EEWRKVRSVMTTAFTSAKLKKVVPTLNKKIAHFKDHLLKLSSPEKFDAQKEFTGFLLEMI
AAIGFGISVDSVEQPDHPLIYHLHKIFAAEGADSFMA
CYP409A1 Locusta migratoria manilensis
No accession number
Enbo Ma and Yanqiong Guo
35% to CYP347A3 Tribolium castaneum
35% to CYP6BK4 Tribolium castaneum
CYP410A1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
30% to CYP350C1 Tribolium castaneum
clone name DPO0820_N05
CYP410A2 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
65% to CYP410A1 Dendroctonus ponderosae
CYP410B1 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
41% to CYP410A1 Dendroctonus ponderosae
missing N-term. This name may change when full length seq is known
CYP410C1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
47% to CYP410A1 Dendroctonus ponderosae
CYP411A1 Dendroctonus ponderosae (mountain pine beetle, bark beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee April 30, 2010
34% to CYP352A1 Tribolium castaneum
35% to CYP4BZ1
clone name DPO0112_O08 CYP4 clan
CYP412A1v1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Nov. 22, 2011
Complete seq. 93% to CYP412A1v2 partial seq
95% to CYP412A1v3 C-term fragment
CYP412A1v2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-3 N-term part only 93% to CYP412A1v1
36% to CYP380C7 Acyrthosiphon pisum (N-terminal)
61% to CYP412A2 (P-4-11)
CYP412A1v3 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
53% to CYP349A1 I-helix to heme
formerly CYP349C1, 95% to CYP412A1v1
CYP412A2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP4 clan
Clone name P-4-11
39% to CYP349A1 Tribolium castaneum N-term
61% to CYP412A1
CYP412A2 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Nov. 22, 2011
Complete seq. 41% to CYP349A1, 58% to CYP412A1
CYP412B1 Rhynchophorus ferrugineus (red palm weevil)
No accession number
Praveen Mamidala
Submitted to nomenclature committee Jan. 26, 2012
42% to CYP412A2 Leptinotarsa decemlineata
CYP4 clan
CYP413A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Liu Ping
Submitted to nomenclature committee June 10, 2010
CYP3 clan
Clone name P-6-12
32% to CYP348A1 Tribolium castaneum
34% to CYP393A1 Dendroctonus ponderosae
CYP413A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Shi Xiaoqin
Submitted to nomenclature committee Nov. 22, 2011
Complete seq.
CYP414A1 Ruditapes philippinarum (Japanese littleneck clam, mollusc)
GenEMBL HQ234335
Linbao Zhang
CYP35% to CYP2K19 Danio rerio
alternative name Venerupis philippinarum
CYP415A1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
36% to CYP6CX1v2 Bemisia tabaci
CYP416A1 Bemisia tabaci (sweet potato whitefly)
No accession number
Yidong Wu
Submitted to nomenclature committee March 2, 2011
36% to CYP401A1 Trialeurodes vaporariorum
CYP417A1 Nilaparvata lugens (brown planthopper)
No accesion number
Chris Bass
Submitted to nomenclature committee April 27, 2011
In the CYP4 clan but less than 40% to any known sequence
CYP417A2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
complete, 77% to CYP417A1 Nilaparvata lugens
CYP417B1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
complete, 43% to CYP417A1
CYP418A1 Nilaparvata lugens (brown planthopper)
No accesion number
Chris Bass
Submitted to nomenclature committee April 27, 2011
In the CYP3 clan but less than 40% to any known sequence
CYP418A2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
complete, 75% to CYP418A1 Nilaparvata lugens
CYP419A1v1 Laodephgax striatellus (small brown planthopper)
No accession number
Jia Shuang
Submitted to nomenclature committee May, 15, 2011
33% to CYP334C1 Pediculus humanus
CYP419A1v2 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
6 amino acid diffs to CYP419A1v1
CYP420A1 Chironomus tentans (aquatic midge)
No accession number
Kun Yan Zhu
Submitted to nomenclature committee May 31, 2011
34% to CYP6AG11 Culex pipiens
CYP421A1 Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
33% to CYP340D1 Bombyx mori
CYP422A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Fang Zhu
Submitted to nomenclature committee May 26, 2011
33% to CYP4BR3
CYP422A1 Leptinotarsa decemlineata (Colorado potato beetle)
No accession number
Jia Shuang
Submitted to nomenclature committee Dec. 26, 2011
100% to CYP422A1 Leptinotarsa decemlineata
nearly complete seq.
CYP423A1 Perinereis nuntia (polychaete worm)
No accession number
Senlin Zheng
Submitted to nomenclature committee Feb. 22, 2011
26% to CYP356A1 Crassostrea gigas (oyster)
30% to CYP1A1 human
in the CYP2 clan
CYP424A1 Perinereis nuntia (polychaete worm)
No accession number
Senlin Zheng
Submitted to nomenclature committee Feb. 22, 2011
35% to an unnamed Branchiostoma sequence in the CYP4 clan
CYP425A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
36% to CYP380C6 Acyrthosiphon pisum, complete
CYP426A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
32% to CYP4CA1 Nasonia,
34% to CYP349B1 Dendroctonus ponderosae, complete
CYP427A1 Laodelphax striatellus (small brown planthopper)
No accession number
Yue-Liang Zhang
Submitted to nomenclature committee Oct. 19, 2011
36% to CYP418A1 Nilaparvata lugens, incomplete
CYP428A1 Plutella xylostella
Gene number CCG013091.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
58% to CYP333-un1/CYP428A1 Heliconius melpomene
61% to CYP428A1 Monarch butterfly
CYP428A1P Bombyx mori (silkworm
Bm_nscaf2827_03
Jun-wen Ai
Pseudogene fragment missing three aa in heme signature
Formerly CYP333-un1
CYP428A1P Heliconius melpomene (common postman butterfly)
No accession number
Ritika Chauhan and Richard ffrench-Constant
Submitted to nomenclature committee June 2, 2011
65% to CYP333-un1 Bombyx mori
missing sme three aa in heme signature as CYP333-un1 seqs
Formerly CYP333-un1
CYP428A1P Helicoverpa armigera (cotton bollworm)
No accession number
Heiko Vogel
submitted to nomenclature committee Feb. 6, 2008
Contig_258 67% to CYP333-un1 Bombyx mori, mito clan C-term
Pseudogene fragment missing the same three aa in heme signature
Probable ortholog to Bombyx pseudogene
Formerly CYP333-un1
CYP428A1P Spodoptera littoralis (cotton leafworm)
No accession umber
Martine Maibeche
Submitted to nomenclature committee Jan. 20, 2012
67% to CYP428A1P Plutella xylostella
missing the same three aa in the heme signature
Is this a new type of P450 with a distorted heme region?
CYP428A1v1 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP428A1v2 Lymantaria dispar (Asian gypsy moth)
No accession number
Chuanwang Cao
Submitted to nomenclature committee Oct. 17, 2012
CYP429A1 Plutella xylostella
Gene number CCG011483.1
Weiyi He
Submitted to nomenclature committee Dec. 4, 2011
38% to CYP347A1 Tribolium castaneum
CYP430A1 Ruditapes philippinarum (Japanese littleneck clam, mollusc)
GenPept ADP24121
30% to CYP18A1 Daphnia pulex
CYP431A1 Perinereis nuntia (polychaete worm)
No accession number
Eun-Ji Won
Submitted to nomenclature committee Feb. 16, 2012
34% to CYP18A1 Daphnia pulex
CYP432A1 Perinereis nuntia (polychaete worm)
No accession number
Eun-Ji Won
Submitted to nomenclature committee Feb. 16, 2012
35% to CYP30B1 Mytilus edulis
CYP433A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
34% to CYP4BN11 Tribolium
CYP434A1 Dentroctonus ponderosae (mountain pine beetle)
No accession number
Christopher I. Keeling
Submitted to nomenclature committee March 30, 2012
34% to CYP352A1 Tribolium
CYP435A1 Harmonia axyridis (ladybug)
CYP436A1 Harmonia axyridis (ladybug)
CYP436A2 Harmonia axyridis (ladybug)
CYP437A1 Glossina morsitans morsitans (tsetse fly)
CYP437A2 Lucilia sericata (sheep blowfly)
CYP437A3 Bactrocera dorsalis (Oriental fruit fly)
No accession number
Yong Huang
submitted to nomenclature committee Sept. 13, 2012
53% to CYP437A1 Glossina morsitans morsitans
clone name 3087
CYP438A1 Lucilia sericata (sheep blowfly)
CYP438A2 Delia antiqua (onion fly)
CYP438A3 Rhagoletis pomonella (apple maggot)
CYP439A1v1 Laodelphax striatellus (small brown planthopper)
No accession number
Lu Xu
Submitted to nomenclature committee June 11, 2012
N-term only, 32% to CYP417A1 Nilaparvata lugens
CYP439A1v2 Laodelphax striatellus (small brown planthopper)
No accession number
Lu Xu
Submitted to nomenclature committee June 11, 2012
3 aa diffs to CYP439A1v1
CYP74 clan animal P450s are grouped together in the CYP440 to CYP499 region
CYP74 clan members have been found in lancelet (Branchiostoma floridae)
Nematostella vectensis (sea anemone), Acropora species (corals),
Tricoplax adhaerens (a placozoan).
CYP440A1v1 Branchiostoma floridae (lancelet, amphioxus)
chrUn:849799011-849806369
THIS SEQ IS 98% IDENTICAL TO ACD88492,
CYP74-like seq epoxyalcohol synthase
between PRDX1 ZCCHC4 SLIT1 and RRM2
84% to estExt_fgenesh2_pg.C_4350040 (next to JUN)
note: PRDX1 is adjacent to JUN in medaka
PRDX1 is next to SLIT1 in lancelet
PRDX2 is next to JUNB and HOOK2 in humans
frameshift = &
Note: SLIT1 on chr15 and chr 1 in medaka is near GOT1 CNNM1
MGNQVGTARLLGWGNQALKPNREEDFVEKNIGFPCRVVTGNKAVQSVFDIELFKKEEFCF
GVAEVRRDFTEGICPSVSSNGKIHEKNKGFLMEVIAKAGEGIPSSTASSVLSNISKWGS
TAMSDFESKLLAVAADTVLPNIFGESSSFNAEDIRLYIIGATEVRSCIVKALTSKNLDEE
RQAVRSIIGKIKTSER (2)
YQQLMDLGHAYGLGEAETTAQLLLPVFFNGVAGIRANLVSSFARLDTISAEDREELRE
EALAALKKHGGLTRESLEEMPKMESFVLEVLRACPSPMFWSTIATRPTTVEYTTESGEHALK (0)
IKEGERVYASSYWALRDPAVFDKPEDFMWRR (2)
FLGPDGDARRKHHVIFHGRLTDTPAVNNHMCPGKDVSLSALKGSIAIFNTFFGWELQEP
PVWTGTKMTRGSQPDYEVKIKSFWVQHPEDLKEIFPSHFRDIID (0)
EVDDVDDIDVLVKTKTGTYSGSGTNSNVYIRLFDDKGHQSRELQLDVWWKNDFEKGQEGQ (2)
YKLKDVKVAAPIVKIELFRDGCHPDDDWYCESVSVQLNPDNSGPTYDFSVNRWIRQ (1)
NDHVWLSPGGCERPQDD &
NPKDD*
CYP440A1-de6b7b Branchiostoma floridae (lancelet, amphioxus)
chrUn:849800964-849801772 (-) strand
Pseudogene fragments downstream, LAST TWO EXONS
YKLKDVKVAAPIVKIELFRDGCHPDDDWYCESVSVQLNPDNSGPTYDFSVNRWIRQ (1)
NDHVWLSPGGCERPQDDVNPKDD*
CYP440A1v2 Branchiostoma floridae (lancelet, amphioxus)
chrUn:230179729-230183425
missing the first exon 99% to CYP440A1 (only 1 aa diff)
YQQLMDLGHAYGLGEAETTAQLLLPVFFNGVAGIRANLVSSFARLDTISAEDREELREEA
LAALKKHGGLTRESLEEMPKMESFVLEVLRACPSPMFWSTIATRPTTVEYTTESGEHALK (0)
IKEGERVYASSYWALRDPAVFDKPEDFMWRR (2)
FLGPDGDARRKHHVIFHGRLTDTPAVNNHMCPGKDVSLSALKGSIAIFNTFFGWELQEPP
VWTGTKMTRGSQPDYEVKIKSFWVQHPEDLNEIFPSHFRDIID (0)
(seq gap)
YKLKDVKVAAPIVKIELFRDGCHPDDDWYCESVSVQLNPDNSGPTYDFSVNRWIRQ (1)
NDHVWLSPGGCERPQDDVNPKDG
CYP440A2 Branchiostoma floridae (lancelet, amphioxus)
chrUn:734687979-734694391 (-) STRAND
estExt_fgenesh2_pg.C_4350040|Brafl1
25% to CYP8b.c, 23% to CYP7B1 human
This is CYP74 like with 9 aa insert in heme region
NEAR JunB or JunD
Jun is next to a CYP2 like gene
MGSVLGTLQLLGWNNQMLKPNREEDFVEKNIGFPCRVVTGNKTVQSVFDIDLFKKEEFCFGVVGEVRKDFTEGV
CPCILSNGKIHEKNKGFLMEVIAKAGEDIPPSTALSVLSNISKWGSTPMSDFESKLTDVAADAFLPNIFGESTH
FHGEEIRLYRSGAIAVRLSIVKALTGRNLDEERRAMTSILEKIKTSER (2)
YQQLLDLGKSYGLGEKEATAQLLFPVFINGAYGLAAHLVCTFACLDTISAEDREELREEAL
AALKNHRGLTRESLEEMPKIESFVLEVLRFCPNPVFWSTIATCPTTVEYTTDSGEHTLK (0)
IEEGERVYASSYWALRDPAVFDKPEDFMWRR (2)
FLGPEGDALRKHHVTFHGRLTDTPAVNNHMCPGKDVSLSALKGSIAIFNTFFG
WELQEPPFWTGKKLSRGSLPDNEVKIKSFWVQHPEDLKEIFPSHFQDIVN (0)
EVDDVGDIDVLVKTKTGKYSGSGTNSNVYIRLFDDKGHQSRELQLDVWWKDDFEKGQEGQ (2)
YKLKDIKVAAPIVKIELFRDGCHPDDDWYCESVSVQLNPDNNGPTYDFPVNRWIRQ (1)
NDHVWLSPGGGEPPKDDVNPIDD*
CYP440A3P Branchiostoma floridae (lancelet, amphioxus)
chrUn:748632437-748635296 (+) strand
70% to CYP440A1
missing last two exons
MGNAFGYLHWLKSNNQAFAPDRTEDFVEKNIGFPCRVVTGNKAVQSVFDIDLFKKEEFYF
GQIEVRKDFTEGVCPSITSNGKIHERNKALMMDIIAEAYKEIPTSTANAVLSNIARWGRR
PTKFESKLFAVSAGALLPTIFGKSTHFNAEEIELYITGSTELRPECLAALSEGNELVEG
RPAIAYILEKMKTSER (2)
YHQLIDLGKSHGFGEAETTGQLLFTIMFNGVAGMAVNLVPSFARLDTISAEDREELRK
EALAALKKHGGLTREALAEMPKIESFVLEVLRACPAPDFWSTIATRPTTVKYSTESGPQEVE (0)
IKEGERVYASSYWALRDPAVFNKPDNFMWRRFLGPEGKARREHHVTFHGRLIDTPAANN
HMCPGKDVGLSVIKGSIAVLNTFFGWELEEPPVWTGTKAARLGQPDNEVNINSFWLQHPN
DLKAVFPSYFDDIID ()
xxDAAGIDVFVKTKTG
CYP440A4P Branchiostoma floridae (lancelet, amphioxus)
chrUn:748668374-748674804 (+) strand
92% to CYP440A2, 82% to CYP440A1
no start MET, missing last three exons
IGNVLGTLQLLGWNNQMLKPNREEDFVEKNIGFPCRVVTGNKAVQSVFDIDLFKKEEFCF
GIGEVRKDFTEGVCPCIQSNGKVHEKNKGFLMEVIAKAGENIPSSIALSVLSNVSKWGS
TPMSDFESKLADVAADAVLPNIFGESTSFPGEEIRLYRSGAIAVRSSVIKAFTGMNLDEE
RRAMTSILEKIKTSER (2)
YQQLLDLGKSHGLGEKEATAQLLFPVFINGAYGLAAHLVGTFACLDTVSAEDREELRQ
EALAALKKHGGLTHESLEEMPKIESFVLEVLRVCGNPVFWSTIATRPTTVEYTTDSGEHTLK (0)
IEEGERVYASSYWALRDPAVFDKPEDFLWRR (2)
FLGPEGEGLRKHHVTFHGRLTDTPAVNNHMCPGKDVSLSALKGSIAIFNTFFGWE
LQEPPFWTGKKLSRGSLPDNEVKIKSFWVQHPEDLKEVFPSHFQDIIA (0)
EVDYVGDIDVLVKTKTGKYSGSGTNSNVYIRLFDDKGHQSRELQLDVWWKNDFEKGQEGQ (2)
CYP440A5 Branchiostoma floridae (lancelet, amphioxus)
chrUn:631107406-631111508 (+) strand
95% to CYP440A3, 75% to CYP440A1
MGNAFGYLNWLKSNNQAFAPDRTEDFVEKNIGFPCHVVTGNKAVQSVFDIDLFKKEEFYF
GQIEVRKDFTEGVCPSITSNGKIHERNKALMMDVIAGAYKEIPTSTANAVLSNIARWGRR
PTKFESKLFAVSAGALLPTIFGKSAHFNAEGIELYITGSTELRPECLAALLEENDLIEG
RPAMAYILEKMKTSER (2)
YHQLIDLGKSHGFGEAETTGQLLFTIMFNGVAGMAVNLVPSFARLDTISAEDREELRE
EALAALKKHGGLTHEALAEMPKIESFVLEVLRACPAPDFWSTIATRPTTVKYSTESGPQEVE (0)
IKAGERVYASSYWALRDPAVFDKPDNFMWRRFLGPEGKARREHHVTFHGRLIDTPAANN
HMCPGKDVGLSVIKGSIAVLNTFFGWELEEPPVWTGTKAARLGQPDNEVNINSFWLQHPN
DLKAVFPSYFDDIID (0)
PDDSDVAGIDVLVKTKTGKYRGSGTNSNVYIRLYDDKGHQSRELKLDVWWKNDFEKGQKGQ (2)
YKLKDVKVAAPIVKIELFRDGCHPDDDWYCESVSVQLNPDNKGPTYDFPVNRWIRK (1)
NDHVWLSPGGCESSQDDVKPKDG*
CYP440A5-de5b Branchiostoma floridae (lancelet, amphioxus)
chrUn:631100697-631100849 (-) strand
85% to CYP440A5
EVHDVGDIDVLVKTKTGKYRGCGTNPNVYIRLYDDKGHQSRELQLDVWWKN*FEKRQEGQ
CYP440A6 Branchiostoma floridae (lancelet, amphioxus)
chrUn:174738028- 174742047 (-) strand
about 400kb from a CYP4 seq that is about 250kb from another CYP4
MGNALGYLKWLKSNNQAFAPDRHEDFVETNIGFPCRVVTGNKAVQSVFDVDLFRKEEFYF
GPIEVRKDFTEGVCPSITSNGKIHERNKALMMDIIAEAYKEIPTSTANAVLSNIARWGRR
PVDFESKLFAVSAGALLPTIFGKTTHFNAEEIELYISGSTELRPDILAALLEGKDLAEGR
PAMAYVLEKMKTSER (2)
YHQLIDLGKSHGFGEKETTGQLLFSIMFNGVGGMAVNLVPSFAHLDTISAEDREELREEA
LAALKKHGGLTREALAEMPKIESFVLEVLRACPAPDFWSTIATRPTTVKYSTESGPQEVE (0)
IKEGERVYASSYWALRDPAVFDKPDNFMWRRFLGPEDKARREHHVTFHGRLIDTPATNNH
MCPGKDVGLSVIKGSIALLNTFFGWELEEPPVWTGTKAARLGQPDNEVNINTFWLQHPND
LKAVFPSYFDDIID (0)
DSDVAGIDVLVKTKTGKYRGSGTNSNVYIRLYDDKGHQSRELKLDVWWKNDFERGQKGQ (2)
YKLKDVKVAAPIVKIELFRDGCHPDDDWYCESVSVQLNPDKKGPTYDFPVNRWIRQ (1)
NDHVWLSAGGCEPTKDDMKPKDG*
CYP440A6-de6b Branchiostoma floridae (lancelet, amphioxus)
chrUn:174729819-174729884
DHMWLGPGGCEPSQDDVKPKDG
CYP440A7P Branchiostoma floridae (lancelet, amphioxus)
chrUn:817607346-817609213
52% to CYP440A1, extension part only.
Stand alone lipoxygenase?
DAKNKMDVTVRTKTGSHFGSGTNGNIFVQIQSSKQHSSGELQLDVCWKNDFEKGEEGE ()
YKLKDVEVCSPVRELMVRRDETCPNDDWYCESISVELQPNSNGPTFYFPVDRWLNA (1)
QSLWLAPGGVALPQKDRHRD
CYP440A8 Branchiostoma floridae (lancelet, amphioxus)
chrUn:725058106-725061232
missing the last three exons
82% to CYP440A6
MGNALGYLKWLRSYNQVFSPDRHEDFVETNIGFPCRVVTGNKAVQSVFDIDLFRKEEFCF
GPVEVRQDFTDGVCPSITSNGKIHERRKALMMDVIAEAYKEIPASTANAVLSSIASWGRR
PTDFESKLFAVSAGALLPTIFGKTTHFNAEEIEVYMSGMIELKPDS
FLATLLALLEGNKR
IEGRRAMANILEKMRTSER (2)
YLQLMDLGKSHGFDKTDTTAQLLFMATFNAVVGMAANLVASFARLDTIRAEDREELREEA
LAALKKHGGLTGEALAEMPKTESFVLEVLRASPSPDFWSTIATRPATVQYSTESGPQKXX ()
IKAGERVYASSYWALRDPAVFDKPDDFVWRRFLGPEGKARREHHVIFHGRLIDTPAPSNH
MCPGKDVGLSVIKGSIAILNTFFGWDLEEPPVWTGTYAARLGKPDREVKIKSFWLQHPNV
LKEIFPSNFDDIID (0)
CYP440A9P Branchiostoma floridae (lancelet, amphioxus)
chrUn:289421392-289429096 (-) strand
missing the last three exons with frameshifts = &
88% to CYP440A3P, 87% to CYP440A6
MGNALGYLKWLKSNNQAFAPDRHEDFVETNIGFPCRVVTGNKAVSVFDIDLFRKEEFYF
GPIEVRKDFTEGVCPSITSNGKIHERNKALMMDVIAGAYREIPTSTANAVLSNIASWG &
SRPTDFESKLFAVSAGALLPTIFGKSTHFNAEEIEAYISGSTELRPECLAALSEGNELIEGRR
AMADILEKIKTSER (2)
YLQLMDVGKSHGFGEAETTGQLLFTVMFNGVVGMAANLVAAFARLDTISEEDREELREEA
LAALKKHGGLTGEALAEMPKIEIS &
FVLEVLRAGPAPDFWSTIAARSTTVRYSTESGPREVE (0)
IEAGERVYASSYWTLRDPAVFDKPDDFVWRRFLGPEGKARREHHVIFHGRLIDTPAPDNHMC
PGKDVGLSVIKGSIAILNAFFGWELEEPPVWTGTDAARLGQPDNEVKIRSFWLQHPNELKEIFPS
CYP440A10P Branchiostoma floridae (lancelet, amphioxus)
chrUn:590392841-590397036
94% to CYP440A8
MGNALGYLKWMWSYNQAFAPDRHEDFVETNIGFPCRVVTGNKAVQSVFDIDLFRKEEFCF
GPVEVRKDFTDGVCPSITSNGKIHERKKALMMDVISEAYKEIPASTADAVLSSIASWGSR
PTD
(seq gap)
NILEKMRTSER (2)
YLQLMDLGKSHGFDETDTTAQLLFMATFNAVVGMAANLVASFARLDTIRAEDREELREEA
LAALKKHGGLTGGALAEMPKIESFVLEVLRACPSPDFWSTIATRPATVQYSTESGPQEVE (0)
IKAGERVYASSYWALRDPAVFDKPDDFVWRRFLGPEGKARR
(seq gap)
LEEIFPSNFDDIID (0)
(seq gap)
(1) DHVWLSPGGCEPPHGDGDTPRMCVYSFTWRPRGCGDA*
CYP440A11P Branchiostoma floridae (lancelet, amphioxus)
chrUn:716344583-716346554
73% to CYP440A1v1
YQQLLDLGKSHGLTEEETTGQLLFTAFFNGIAGTTVNIVGSFARLASISGEDREELREE
ALAALKKHGGLTPEALGEMPKVESFVLESLRANPSALIWGFVAPRPTTLKYTAKSGEREV
E (?)
IKEGELVLASSYWVLRDPAVFDKPEDFVWRRFLGPEGEARRQDHVVFMGRLNDTPAPSNY
MCPGKDAALSLLKGSVAIFNTFFGWELQEPPVWTGTKFLRSAMPDNEVKIKKFWVQHPED
LKDIFPSHADDI
CYP440A12P Branchiostoma floridae (lancelet, amphioxus)
chrUn:82568948-82571407 (-) strand
86% to CYP440A11P
YQQLLDIGKSHGLTEEETTGQLLFTAFFNGVAGTAVNVVGSFARLDSISGEDREELREE
ALAALKKHRGLTPEALGEMPKIESFVLESLRANPSALLWGFVAPRPSTLKHATKSGDREVE (0)
IKEGELVLASSYWALRDPAVFDKPDDFVWRRFLGPEGKARRENHIVFMGRLTDTPAPSNY
MCAGK ()
AIFNTFFGWELQDPPVWTGTKFLRSAMPDNEVKIKKFWVQHPEDLKDIFPSHADDIID ()
CYP440A13P Branchiostoma floridae (lancelet, amphioxus)
chrUn:847850446-847850592
79% to CYP440A6, lipoxygenase part only
97% to CYP440A15P 1 aa diff
IDVLVKTKTGTCRGAATNSNVFIRLYDDKGHKSRACQLDVWWWNDFERG
CYP440A14P Branchiostoma floridae (lancelet, amphioxus)
chrUn:768662609-768662776
73% to CYP440A1v2, lipoxygenase part only
YELTDVKVAAPILQLELWRDNSCPDDDWYCDSVSVQLSPDSSGPTYDFPVHRWIKQ
CYP440A15P Branchiostoma floridae (lancelet, amphioxus)
chrUn:309187292-309187438
lipoxygenase part only
97% to CYP440A13P 1 aa diff
IDVLVKTKTGTCRGAATNSNVFIRLYDDRGHKSRACQLDVWWWNDFERG
CYP440A16P Branchiostoma floridae (lancelet, amphioxus)
chrUn:349569472-349569624
lipoxygenase part only
68% to CYP440A7P
DVRVKTKTGSHYGSGTDGNIFIKIISDNGQESDEYQLDVWWKNDFEKGQEG
CYP440A17P Branchiostoma floridae (lancelet, amphioxus)
chrUn:458307928-458307993
lipoxygenase part only
95% to CYP440A16P 1 aa diff
HESDEYKLDVWWKNDFEKGQEG
CYP441A1 Branchiostoma floridae (lancelet, amphioxus)
chrUn:369420088-369423879 (+) strand
estExt_fgenesh2_pg.C_1200087|Brafl1
22% to CYP74B2, 25% to CYP74F1 rice
(29% to Nematostella XM_001636310.1 12 exons)
next to SLC24A5 (P450) FCNB/FCN2 (P450) MEIS2
note: amphioxus has a CYP4F seq between GALTN12 and FCNB
(14142000-141440000)
note CYP19 is about 400kb from SLC24A5 in medaka
1244338 MGNCCSNYAGMWRALQQGNYSIKEINYGGADATVLRRNIGVTVVSLLDQHNIRYVFDMDLVEKVPFTLGNTALRPAVLGG
HCPGMLSNGVEHVRRKEFAMAVIQRSLTNSLFSTMVEQLHAHTSMWATVGHNIYDFEDRVNRFCADAVSTVILGTTLPYE
SVRAWQNGLHSHRPRVPTLGRYLAKSHALRALPVLLRNIRNAPAYEDIIHLGKTCGLTEEEATHEILYTIVGHALPQVQN
PLLACLAAYAAMPDLDRRQMWEEMNK (0) 1245135
1247089 VLHNVGTFTETVLGSMTCVESFILEVLRLRPPMEMFFGRARKDFIVKTRDREIFQ (0) 1247256
1247668 VHEGEVVCGSAFWAGRDPTSFRVPIMFRRNRFACPGSEALRGSLIFGRGPLTFLPTNENHQCPGLELAMGVLKPSMAWL
LMFCKWKLTEEPKWSGKKRSRCGKPDNPMGMVTFKYYPTDVANYYPLPGVTPSNEKGKPGKDNSPNVSSFVSSIL* 1248132
CYP441A2 Branchiostoma floridae (lancelet, amphioxus)
chrUn:369479230-369482389
Two genes nearly identical (3 aa diffs)
45 kb apart (possible assembly error?)
estExt_fgenesh2_pg.C_1200094
1303480 MGNCCSNYAGMWRALQQGNYSIKEINYGGADATVLRRNIGVTVVSLLDQHNIRYVFDMDLVEKVPFTLGNTALRPAVLGG
HCPGMLSNGVEHVRRKEFAMAVIQRSLTNSLFSTMVEQLHAHTSMWATVGHNIYDFEDRVNRFCADAVSTVILGTTLPYE
SVRAWQNGLHSHRPRVPTLGRYLAKSHALRALPVLLRNIRNAPAYEEIIHLGKTCGLTEEEATHEILYTIVGHALPQVQN
PLLACLAAYAAMPDLDRRQMWEEMNK (0) 1304277
1306472 VLHNVGTFTEAVLSSMTCVESFILEVLRLRPPMEMFFGRARKDFIVKTRDREIFQ (0) 1306636
1307061 VHEG 1307072
end in a sequence gap
CYP442A1 Branchiostoma floridae (lancelet, amphioxus)
chrUn:867286912-867289314 (+) STRAND
fgenesh2_pg.scaffold_781000005 [Brafl1:110589]
23% to CYP74B2
Scaffold 781
96% to fgenesh2_pg.scaffold_402000022
between TFCP2 and MDH1B
MGVSMSNTKGLVRHVKAGPRALKPGGEHPAAVRTNVGIPVVALLNQDTIHHVFNTDLVDKEQYCLGYVGV
RSELLRGHCPSMFANGQEHRRKKAFLIDVFRGRQKTLPPVLSRQIMAHFKEWSRLEALADFEDKVFFLMS
DILTETVFGRKLDGRLALHWLQGLPSVRTWIPFPTKAKQDLAASALPVLLKSIEESPNYEELIQLSYLHD
IEEEDAIDNILFVIVFNAVAAVSAVIVTFITRLHTITEADRNVLLKTTLQALLKHESLSEESLGDMKALD
SFLLEVLRLHPPVFNFFGVAKKDFAIPTGVDKNVE (0)
VRQGEQLMGSCFWAQRDAKVFLSPNVFRCYRFMDSKELLVDREQDGGKKRHLIFGHGS (2)
LTEAADL (frameshift)
DSHQCPGQDIAFYLMKATLAVLLCYC
SWELEALPVWSDKTARLGRPDDLVSLTWFNFDSDTARHVLESYDLNCEK*
CYP442A2 Branchiostoma floridae (lancelet, amphioxus)
chrUn:711402302-711404745 (-) STRAND
fgenesh2_pg.scaffold_402000022 [Brafl1:102192]
Scaffold 402
57% to fgenesh2_pg.scaffold_107000039
96% to fgenesh2_pg.scaffold_781000005|Brafl1 (probable allele)
between SAP18, salmo mk67i, mdh1b and UBP1/TFCP2
NOTE: IN ZEBRAFISH mki67ip is near tfcp2l1, ddx18 and ccdc93
MGVSMSNTKGLVRHVKAGPRALKPGGEHPAAVRTNVGIPVVALLNQDTIHHVFNTDLVDKEQYCLGYVGV
RSELLRGHCPSMFANGQEHRRKKAFLIDVFRGRQKTLPPVLSRQIMAHFKEWSRLEALADFEDKVFFLVS
DSLTETVFGRKLDGRLALHWLQGLPSVRTWIPIPTKARQDLAASALPVLLKSIEESPNYEELIQLCYLHD
IEEEDGIVNILFTIVFNAVAAVSAVIVTFITRLHTIIEADRNILLKTTLQALLKHESLSEESLGDMKVLD
SFLFEVLRLHPPVFNFFGVAKKDFAIPTGVDKNVE (0)
VRQGEQLMGSCFWAQRDAKVFLSPNVFRCYRFMDSKELLVDREQDGGKKRHLIFGHGS (2)
LTEAADLDSHQCPGQDIAFYLMKATLAVLLCYC
SWELEALPVWSDKTARLGRPDDLVSLTWFNFDSDTASHVLESYHLNCEK*
CYP442A3 Branchiostoma floridae (lancelet, amphioxus)
chrUn:342749929-342752450 (+) STRAND
fgenesh2_pg.scaffold_107000039 [Brafl1:81984] 27% to CYP7D1
Scaffold 107
61% to fgenesh2_pg.scaffold_402000022|Brafl1
51% to estExt_fgenesh2_pg.C_1950037
next to GALNTL6
816169 MGACMSDTSGLLNTKKSGPHVLNPRGEHPTIVRTNVGIPCVGLLSQETIQYVFDPELVDKEPCCFGYSEVPGDV
RRGHCPSMFANGQEHRRKKAFLVDVFKECRDKIQTVLFKTILEDFEEWSRVKTVPDFEDRVYFLISKAVT
EAVFGTKLDGRLALTWLEGAIQLKTWLPIPNYAKRHRLAVAALGELMKTIEESPKYEELIRMCHLHDLEA
EDGMMTLMHAILFNGCGAVTTTIITSVARYQTIPAGERKDLQTSVLQEVEKFGSITEESLGEMEFLESFL
LEVLRMHPPVADFWGVAKKDFTVSAGEIKEE (0)
IRKGERLLGSCFWAQRDVSVFLRPGLFRSRRFLDEKEKRSNLLFPHGS (2)
FLEAASLDSHQCPAMDIAFILMKATLAVLLCYCKWELQDTPEWSDKITRLGKPDGLVSLTSFGFDLVEARRVLEL*
CYP442A4 Branchiostoma floridae (lancelet, amphioxus)
chrUn:494336246-494338984 (-) strand
estExt_fgenesh2_pg.C_1950037 [Brafl1:125761] two genes fused
Scaffold 195, 27% to CYP7D1, 30% to CYP7B1
Neighbor to amphioxus on right side scaffold 195
also on another scaffold
P450 like Nematostella/CYP74
Between GALNT5 and DDX42 GALC
MGGVWSNTYGFIKGVTDGVHMMKPEGEHPSVVRTNPGLPVVALMNQDTIHYAINPETYKKEPYSFGPVGV
SKDVLRGHCPSMFSNDEDHRRKKALLVDAYKQGEKSLPSILFNQIKAHFGEWSRLKDVPDFEERVFHIMS
ETLTEALFGRKIDGQLCFTWLNGLITEAKTWIPMPSLAWKRRQAIKAIPELLKAIETAPKYRELVQLCHT
HGVEVEEGIFTILYGTLFNGCAAQTAAIVSSVARLHTLSDAEKNEIIQTTLQVLEKHGGVSEESLGEMKT
LESFILEVLRLHPPVFNYWVLARKDLVISPEKENIK (0)
VRKGERMLGCCFFAQRDGSVFPDPDRFRWNRFLDEQGGQKKHLFFPRGS (2)
FTEAADLNSHQCPGQDIGFFMMKTTLSVFLCYCSWELKDAPVWSDKPIRVGNPDD
PVRLVRFNFRSEQAGRALVNTSAKKI*
CYP442A5 Branchiostoma floridae (lancelet, amphioxus)
chrUn:654010626-654013026 (-) STRAND
estExt_fgenesh2_pg.C_3320046 [Brafl1:128846] 3 exons, 27% to CYP7D1
Scaffold 332 also 98% identical to estExt_fgenesh2_pg.C_1950037
(allele)
but gene neighbors are different
next to GALNTL5
MGGVWSNTYGFIKGVTDGVHMMKPEGEHPSVVRTNPGLPVVALMNQDTIQYALNPETYKKEPYSFGPVGV
SKDVLRGHCPSMFSNDEDHRRKKALLVDAYKQGEKSLSSILFNQIKAHFGEWSRLKDVPDFEERVFHIMS
ETLTEALFGRKIDGQLCFTWLNGLITEAKTWIPMPSLAWKRRQAIKAIPELLKAIETAPKYRELVQLCHT
HGVEVEEGIFTILYGTLFNGCAAQTAAIVSSVARLHTLSDAEKNEIIQTTLQVLEKHGGVSEESLGDMKT
LESFILEVLRLHPPVFNYWVLARKDLVISPEKENIKVCKGERMLGCCFFAQRDGSVFPDPDRFRWNRFLD
EQGGQKKHLFFPRGSFMEAADLNSHQCPGQDIGFFMMKTTLSVLLCYCSWELKDAPVWSDKPIRVGNPDD
PVRLVRFNFRSEQAGRALVNTSAKKI*
CYP442A6P Branchiostoma floridae (lancelet, amphioxus)
chrUn:444909462-444916776 (-) strand
fgenesh2_pg.scaffold_163000045 [Brafl1:87575]
Scaffold 163
73% to estExt_fgenesh2_pg.C_1940045 pseudogene
next to GLUL, CYP26 IS NOT TOO FAR OFF
MGGVWSDTFGLIKGLVYGPHMLKSEDEYPTAFRTNNGVPAVVLLNRDTIQYVFNPEMYEKEPFYFGYLGT
SKDVMRGHCPSMFLNGEEHRQKKALLIDAYKQGQKALPSVLFKQIKAHFGEWSRLDEVPDFEDRVFHFFS
EALTEALFGRKVDGQLCRTWLNGLLNDFKTWIPMPSMARKRRLAIEAIPVMWKAIEEAP
KY*ELVQLCDTHGV
EAEEGIFTILCGTIFNGIAAERAA
IVSSVARLHTLSDAEKNEIIQTT
LQVLEKHGGVS (frameshift)
GEMKTLESFLLEV
LRLHPPVFNLWGLARKDFIISPE
KENIQ (bad boundary)
IRKGEQLLGSCFWAQRNGSVFP
DPDRFRWNRFVGEDEQGEQK (insertion)
(0) KHLFLPRGS (2)
WTEAYDFDSH
HCAGQDIAFLTMKATLAVLLCYCSWELKDAPVWSDKTLRVGNPDDPVRLTRFSFRSEQAGRALGIRPDNT
YPNSI*
CYP442A7P Branchiostoma floridae (lancelet, amphioxus)
chrUn:444940017-444940794 (-) strand
24kb from CYP442A6P
Second pseudogene nearby 86% to fgenesh2_pg.scaffold_163000045
next to GLUL
VHKGEQLLGNCFWAQRDGSVFPDPDRFRWNRFVGEDGQGGQKKHLFFPRLS ()
WTEAYDFYNHHCPG*DIAFLMMKATLAVLLCYCSLELKDAPVWSDKTIRTGN
PDDPVRLTRFNFRSEQAGRALGIRPDNTYPNSI*
CYP442A8 Branchiostoma floridae (lancelet, amphioxus)
chrUn:493364785-493367391 (-) STRAND
estExt_fgenesh2_pg.C_1940045 [Brafl1:125747]
81% to estExt_fgenesh2_pg.C_1950037, 27% to CYP7D1
scaffold 194 between PIGM and CLIC1 UNC93A
NOT FAR from GALNT5 and DDX42 GALC WITH ANOTHER P450 BETWEEN THEM
MGGVWSDTFGFIKGLVHGPHMMKPEGEHPSVFRANPGVPAVVLLNRDTIQYAFNPETYEKEPYSFGPVCA
AKDVVGGHCPSMFSNDEDHRRKKALLIDVYKQGQKTLPSVFFSQIKAHFEEWSRLEDVPDFEERVFHITS
ETLTEALFGKKIDGRLCYTWGNGIPTDFRTWIPIPPAARKRRQAVEVLPALLKAIKETPKYQELVQLCHT
HGVEVEEGILTILYGTLFNGCGAQTATIISSVACLHTLSDAEKNEIIQTTLQVLEKRGGISEESLSEMKT
LESFILEVLRLHPPVFNYWALARKDLVISPEKENIK (0)
VCKGERMVGSCFWAQRDGSVFPDPDRFRWNRFLDEDEQGGQKKHLFFPRGS (2)
WTEAADLDSHYCPGQDIGFFILKVLLAVLLGYCSWELKDAPVWSDNTFRLGNP
DDPVRLARFNFRSEQAGRALGIRPDNIAPNAI*
CYP442A9 Branchiostoma floridae (lancelet, amphioxus)
chrUn:203694611-203697283 (-) STRAND
estExt_fgenesh2_pg.C_510020 [Brafl1:120723]
Scaffold 51 30% to CYP4V6
87% to estExt_fgenesh2_pg.C_1940045
83% to estExt_fgenesh2_pg.C_1950037
90% to estExt_fgenesh2_pg.C_1940045|Brafl1
87% to estExt_fgenesh2_pg.C_3320046|Brafl1
87% to estExt_fgenesh2_pg.C_1950037|Brafl1
BETWEEN PIGM AND CLIC1 UNC93A
NOTE: IN XENOPUS PIGM IS NEAR GALNT4
623366 MGGVWSDTFGFVKGLVYGPHM
MKPKGEHPSAFRMNNGVPAVVLLTRDTIQYAFNPETYEKDPYSFGPGGVSKDVVRGHCPSMFSNDEDHRR
KKALLIDVYKRGQKTLPSVFFSQIKEHLEEWSRLEDVPDFEERVFHIMSETLTEALFGRKIDGELCFTWL
NGLLTDFKTWIPIPSMSRKRRLAIEALPALLKAIKEAPKYQELVQLCHTHGVEVEEGIFTILYGTLFNGC
AAQCAAIVSSVARLHTLSDTEKNDIIQTTLQVLEKHGGVSEESLGEMKTLESFILEVLRLHPPVFNFWCL
ARKDLVISPEKENIK (0)
VCKGERMVGCCFWAQRDESVFPDPDRFRWNRFLDEDKQGGQKKHLFFPRGS (2)
WTEAPDLDSHQCPGQDIGFFMMKALLAVLLGYCSWELTAAPMWSDKTIRVGNPD
DPVRLARFNFRSEQAGRALGIRPDNIAPNAI*
CYP443A1 Acropora millepora
EZ012168
96% to Acropora palmata EU541487.1
MQVSPIHDEDKEVPGQDKWTF
FHVAELFMKGHGYFYKRRRKYKSSVFKVNMG
VKGIHVCDKKAMKVFFDTSKIYKEPAFGKLHYNICLLDGYTPSMFSNGIPHQKQKAFLVQ
ICKIAQRSKIFDTSLKLIKEYSRNWEKADSQLKATWELSIMDLISDIFTEAFLGTRLDQK
YMYNFLKGSWGKGRVLKKAMEAASCLKQTLQETKGSSDVIEILKMAVNAGITEDQALMDI
LFMLNFNAYGGVSGVLRTCLARLYVLEEDYKQRMKNELKTILSNKELSEASLEEMILLHN
FILEVLRMHPPVPVFFGRARDDFSLETECGTFIVRKDQLLVGNVHMAHRDSSIFDQPDKF
MPSRFEDESIIDHIIYGYGPFHQEATPQNHRCPGQDIILQILKVCLSFILLNCEYALSDA
PKWTGKRLRRIGCPDKPIKLSYFKTKNQEALGPLQVEEM*
CYP443A1 Acropora palmata
EU541487.1 ortholog
1 mdlfhvaelv mkghgyfykr rrkykssvfk vnmgvkgihv cdkkamkvff dmskiykepa
61 fgrlhynicl ldgytpsmfs ngiphqkqka flveickiaq rskifdtslk likeysrnwe
121 kadsqlratw elsimdlisd ifteaflgtr ldqkymynfl kgswgkgrvl kkameaagcl
181 kqtlqgtkgs sdvieilkla vnagitedqa lmdilfmlnf nayggvsgvl r tclarlyvl
241 eedykqrmkn elktilsnke lseasleemi llhnfilevl rmhppvpvff grarddfsle
301 tecgtfivrk dqllvgnvhm ahrdssifdq pdkfmp srfe desvidhiiy gygpfhqeat
361 pqnqrcpgqd itlqilkvcl sfilqnceya ladapkwtgk rlrrigcpdk piklsyfktk
421 kqeavgplqv eem
CYP443A1 Acropora digitifera
aug_v2a.20154.t1 scaf12319:44267-52394(+)
96% to EU541487.1| Acropora palmata cytochrome P450 74A (CYP74A)
97% to CYP443A1 Acropora millepora EZ012168
36% to XM_001636310 Nematostella vect
35% to CYP74F1 rice in C-term part,
9aa insert in heme region YGYG PFHQEATPQ NHRCPG
31% to 4. aug_v2a.20153.t1
CYP74 clan
note: upstream sequence is another CYP74 clan member CYP443D1
MQVSPIHDEDKEVPGQDKWTFFHMAELVMKGHGYFYKRRRKYKSSVFKVNMGVKGIHVCDKKAMKVFFDMSKIYKEPAFG RLQYNICLLDGYTPSMFSNGIPHQKQKAFLVQICKIAQRSKIFDTSLKLIKEYSRNWEKADSQLKATWELSIMDLISDIF TEAFLGTRLDQKYMYNFLKGSWGKGRVLRKAMEAASCLKQTLQGTKGSSDVIEILKMAVNAGITEDQALMDILFMLNFNA YGGVSGVLRTCLARLYVLEEDYKQRMKNELKTILSNKELSEASLEEMILLHNFILEVLRMHPPVPVFFGRARDDFSLETE CGTFIVRKDQLLVGNVHMAHRDSSIFDQPDTFMPSRFEDESIIDHIIYGYGPFHQEATPQNHRCPGQDIMLQILKVCLSF IMLNCEYALSDAPKWTGKRLRRIGCPDKPIKLSYFKTKNQEALGPLQVEEM*
CYP443B1 Aiptasia pallida (Sea Anemone)
GH573698,
GH573482.1 = CCAS1861.g1_c
44% to CYP443A1 N-term
MNKSKKAAISPLPENHLRNIPGSDGSKFTKIFHLLSLLRQ
GQRFFVNKAERYKSTVFRMSIGVKAIAVCDRKGADVLFDLDKIHKEPKFGRLNYNVCLVD
NKTPSIFTNGSQHESQKAFLMKVCQIAQNADILDTVNKIIPEYLERWHRADGKLKASWET
DVMALVSDIFSQAFLGVRFDPSAMHDMVYASWTRKNWELVRGMVASNRMMETLKQSPKLN
DILEISRENGLSDEQTVADVLFMLKFHGYGAVSGALR
CYP443B1 Aiptasia pallida (Sea Anemone)
C-term
GH573481.1 = CCAS1861.b1_c
45% to CYP443A1
SRFEDESLLEHMIFTNGPFKQEATPQNHHCAGKEIIFTVMKAVLIPVILSCSFTFTQTPY
WTGKKLRRIGCPDNKLELKEFMFTPREGFTKREDLQVEDIS*
CYP443C1 Nematostella vectensis
FC187177.1
FC187176.1 CAAB7309.rev opp end of FC187177.1
FC210715.1 CAGF12396.fwd
ABAV01006594.1
47% to CYP443A1, 47% to CYP443B1
note: adjacent gene in first 4000bp of this contig is a FAM20 member
The region in Amphioxus near FAM20 is also close to
PRDX1, RAD23A and AK3
FAM20C in chicken is near PDGFA, PRKAR1B, HEATR2 and CYP2W1
FAM20A in chicken is near PRKAR1A, WIPI1, KCNJ14
15833 MAKAFKNRSPVVTPVSDVEQVPGSDKQRLFHLVRLVM (0) 15723
13722 LGQGYFRKRMEKCRSPVFRVNMGVKGVAICDRKAIDAMFDVKV (0) 13573
12786 IRKEPAFGRLNYNLILLDNYVPSIFTNDTPHERQKAFL
MKICQTAQEAQILPTTQRVVTQYLERWGKA (1) 12583
12174 DANLKQDWENDVRAMLSDIFTEAFLGVSVNPTLMYNMVKGSWAKPGSK (2) 12031
11858 LFKTADDAARLLREFLREALQKSTKLQSLLSTAVDAGVTEEQALADILFMLK (2) 11703
11500 NFNAYGGVSGALIGCLARLTVTDPKYKDAMRHEVISAVDKDGVTHESLNQMNRLHWFVLE (0) 11321
10189 NLRMCPPVPLFFGRAR (2) 10142
9137 NDFILHSSRGSFDIKADELLVGNVYEIHRDPNVFVNPEVFMPSRFEDGVQ (0) 8988
8595 RNKLLEYMLPGNGPIKESPTASNHQCPGL (0) 8509
7860 DITFTVLKTALMYVVTCCDFSLTRIPIWTGKK (2) 7765
7658 LRRIGSPDNIVQLLSFKYSP (0) 7599
7074 RRPLVHRNSLQIDDLEEKHNYLENSSTFQKH* 6979
CYP443D1 Nematostella vectensis
XM_001636310
ABAV01006594.1 contains two P450s about 1kb apart both on (-) strand
36% to CYP443A1, 33% to CYP443C1
24971 MEGEDGDMRGIPGTYGSKLYHLVKFVKLGHLFFVDQTRKYKSSV
FKCNFFGTPFIALTDFKGVTALFDPNKVEKEEGFGSFRFNKDLLDGHVPSMFSNDSQH
VRKKEFLIKIAKSMKMQTLMPNILDIMPEHLIKWHFREGKGMSSQEEWEDRILLLASD
IMSETLLGIRLDGDAFLNWRFSVLKPTKKTCGRPSKKSQAAMDSLEHLKAAVENSPNI
DEIYEAAEKFGISHEEAVLEILWMLNFNASPGTGAAMRSAAARLSLMSKEKKNEMKEE
IKMHLGTVGLNLRTLKKMNKLDQFTCEVLRMHPPVALFFGVARRDFVVETKTGNYRIR
RGQRLLGNCHLAQRDPEVFETPGAKCVDTFDPDRFSLNETLKPNLLCTHGRMNQKPSG
MDHNCAGAHVGIITLKTFILYLILFCDWELEEKPYWTRTNLIRYGNPDEPIRLKSFKY
TRDK (0) 17406
17159 EELLLPDQPDSSSDDELPDLRPQIPQNMEEDDE* 17058
CYP443D2 Anemonia viridis (Symbiotic sea anemone)
FK732505.1,
71% to CYP443D1
PVALYFGKARKTFVLESNSGRFRIRKGERLLGNCHIAQRDPCEFIVDGCKGVDDFDYVRF
LRNPTLKSKVLCSHGMMNESPSPNNHKCAGSHVGIITLKTFILYLILFCDWELEEKPFWT
RTTLIRYGNPDEPIKLKSFKYTRDKEELLLPDQTDSAASTEDELDGGPDLRCPIPHDIQD
PNEEV*
CYP443D3 Acropora digitifera
aug_v2a.20153.t1 scaf12319:23525-39513(+)
54% to CYP443D1 XM_001636310 Nematostella vectensis
60% to CYP443D2 Symbiotic sea anemone (Anemonia viridis)
upstresam gene similar to carnitine acetyltransferase
[aug_v2a.20152.t1 scaf12319:10723-19622(-)]
upstream of that is dolichyldiphosphatase 1-like DOLPP1
[aug_v2a.20151 scaf12319:2689-8802(+)]
EDGEPEPIPIPGSFNGRIPQIVELVT (0)
KGHHFFQSRMESLASTVFKCSFFGAPFVAITDYEGMQCIFDPKF (0)
VEKEPGFGNFRFNQSLLEDHVPSMFENGDRHSNS &
KSFLIAISQ
NMLRMGRLIPNVMDIIPEHLIKWNFKEGQGSPSQEEWEERILHLSMDILSECMLGIRLSGHSFIQWRFEVLKEERTCFGK PRGKYKKALHAFNHLKEAIANAPDIEPVFKEAEKVGLTEEEAVLEILWMLNFNAAPGTGAAMRSAAARLSVMTTEEKREL RSEIRECLGPIGLNLKTLHKMKKLDNLVCEVLRLYPPVALYFGVARRPFIMKSSSGTYHIQKGQKIVGSCHLAQRDKGVF SVEGCKEVDEFDPTRFNKKGLKSKLICAHGPLSEPPSPDNHKCTGTNVGYVIIKCFVMYLIMFCDWNLEEKPYWTDKSLVRYGNPDEPIRLKYFKYTRDK (0)
EELLLPDQPDSSSSSEDDENQDADTVISECPVEEPDAEGNCPV*
CYP444A1 Trichoplax adhaerens
estExt_fgeneshTA2_pg.C_20552|Triad1
CYP74 clan.a Trichoplax
28% to CYP443A1
36% to CYP444C1
MEVLSRKLHRRRRSSREDTIQSIPGSHGHKFISSFKLQQQGNLYFKTLQQKYQQNVFRINIGVRAIALVDNRVIRILFQN
DKVTKEDGVGNYITNYNLMDSLRPSIFSDQKDRMSRNSFILQTLAAMQDKYIIQQTYNSIEDHFQRWNKTYQPTASKSIQ
PSWDDGIQHLCCDIICRLFIDKTVNFESIFQWYVQALQKIKVPGLLKQRQCADIYNTYIELFKEIENSTYLPYYLNTGRQ
CSLSDEYAKENVLFGIIFNAFGSCEAIMRTCAARIGILSHEDRNQLRQEIQSTLGEGNDLSLAALTKMKRLRSFVAEVLR
TSSPISLIFRRAKQDMFIQAYTGTYKISKGHLLVGNIHLAHRDPNVFPEPDTFKPFRFYDDPELIRHMIWEAGVYPDEAK
NLSHQCPGKKMMMILLQLFCMKLLIHTEFQFDVTPDWNEKHLHSLGCPDGCLTLNQFSYDPAMFKIKLSDDICNSHSPFL
HCED*
CYP444B1P Trichoplax adhaerens
jgi|Triad1|53403|fgeneshTA2_pg.C_scaffold_2000560
CYP74 clan
(second of 4 in a cluster) XM_002109926.1
heme region is incomplete, no Cys
MDNDKEMESTKPEEKRDTIPGFFTSLNNWYCMSKLQHKGHLFFHEEQQRHKRSIFRVNLGYDAIAILTNE ESQLLFDSSKVAKEDCYGIALQNVQSLTNYPIASLWSDQAKKDRKSLINDVVQLIPVNYFIKVVSDTIKE HFQRWEDKYEVYLGNGPPGNWERDIQEFCSNAISSLLLGTRVEFQSASDCLEAMLMISRLFVKTGSFNRG IKATKVLLQQIEQSPNFKKLAKIGECYSLTQDFVKINILYIMMQDKEHLIQSTSQVLTNHSGLSESAMLD MTDLKSFVMETLIANNGLYHINTPNRNDMNISVDGSTYNIRKGQRLLANLYWANRDPKWFDNPDEFQPFR FSNYPSLKRCLLWEYGCFGDEFEGLEENKIIPVRDVADARSLLFSAGNQYYVIKTTTTITRFRDGKPVVE VNEEYKSGQGKDGMSELKSVLKANDINESVIHTVNHSTTSNLGSAHKNVIIRKRSRKQKQKSTEKND*
CYP444C1 Trichoplax adhaerens
jgi|Triad1|63648|estExt_fgeneshTA2_pg.C_20554
CYP74 clan (third of 4 genes in a cluster)
MKVEPVNSDDNPKKVANSLGWTIPSVMKLLKEGNLYFKTIQEKTGHTIFRINLGVEAFALCDSQSATAVF DYSKVTKDDGFGRLKFNKNLTGQIRPSIFCNGEVHERYRKFLMDVFRATSVDYLIKVTNEAVEKHFSLWE KSYTGAGIAKEWEMDILRLCSDIVHRAILGGEISSEASHNWLMGILKKKRSALGVKTKFFSKAIVGYAIL TNGIKESPHYQSMIKLADKRSVSEEEALNNILFSILFNYYGGCSAAFRTCAARISILDENIKSELIEDIK SAIDKYGGLTGQALCQMRKLHSFVLENLRMSSPVNLIFGRAVEDLMIKSNTGTYKIPKGKLMVANLFWAH RDTRVFDDPLTFQALRFFNNPDLKNYLYWEAGPFSKDQCEKTHQCPGRNIAIPSIMLFSAYLLLQGDYQL GSEPQWTGKKIRRLGTPDEIITLKKFKYKSDVTVSLPEAVLNSKLKYDEMTAENNNSQCPVDSEA*
CYP444D1 Trichoplax adhaerens
jgi|Triad1|53405|fgeneshTA2_pg.C_scaffold_2000562
CYP74 clan (fourth of 4 genes in a cluster)
This gene model is fused to adjacent gene XAB2 (assembly error
P450 part 39% to CYP441C1, 38% to CYP444A1
All ARE ON MINUS STRAND
MFRKNR TSITPEDEPREVPGKFGSVTFNAIKMIKNGNTFFKQYEEKYNSTVFRVYAGAKVVALLDNIAIQTLFDHD SISKEDGFGKVRLNFDLMANIRPSIFSNDQSHIRRKRFIMQILRHIPANYMIKIADKIIRRHFEAWSNKY SYSHRENSVAGDFESEIQEVCSDIITTLFLGSKGNVAALQNWISGIFERSRRLGLMKTKSYVNAYIGYQE MMKHIERAPTLKKIVQIAGEHSLDVEDAKHNLLFAMVFNAYGGCNCVIRTCAARIALLKEAERERLIAEI KLRLENHNGLSANSLYQMRTLESFVLEVLRTSPPISMIFGRTKRDLVIYSSSGKFKVVKGQLLAGSIYSA HRDPTIFKNPEEFRPFRFIEEPALKQNIVWEAGPYTVNATEDSHQCPGKGIAIPLIEVFCLYLLLHCQYT LNKEPIWTGKKSSRSGCPDEPISLKQFSFQPAKFSVNLPTHVLDSFNLLGPDTAFDAVAH*
CYP445A1 Clytia hemisphaerica (Cnidaria; Hydrozoa)
CU428092.1, CU430258.1, CU433515.1
MGNLFSSKAPRCEKKKPEPIPKDLPEVPYA
GSENPQENLANLGKIKGPYYINQVMKESGLGVFKLRLFEERIILADPIAINVIYDPELTE
KSVDFGLANVNGFTLRGYFPTATVDGDDKATKKAGMWKILSMAEEKHGNDGLYKILKKHW
ESVLPLIKDEETNVDNLIDVVTVKTLTEFFFDKAFDLDLKTFLVWFFKGLTPKSTPGLELD
VVGKQVTEQMYGYLDSTPWAQNVLPELIKADCRDAETLKSEALFFAFVFSAFGLKSGLSS
TIPLFLNLDEETRNKILEEVDTFNQDDGKSMDDKLKAFDVTDRFATEVFRYLPPVVQVQG
RAKKDFVLNSLKGKYLVKKGSYMTGYSYGAQRNPNAVRCPYQFSTTGDQKHIKENFFAFG
GPYNQEPQNDNRKCLGQYISLNMTKMFVALFARCEIEVVSSLKFTEANPNRVIASDEPLR
VSKFECPHK*
CYP445A2 Clytia hemisphaerica (Cnidaria; Hydrozoa)
CU428303.1, CU431206.1
59% to CYP445A1
MKTLLVTVCVLLSCAASVQSHEELNDFFRFFKFDYGRGKE
KEYPEVPYAGSKDPRVNIAQLAKLKGNYY
LHELSKKSGLGVYKLKLFEDRIILADPVAIKAVYDTELTEKSTDFGLALMSGDIVKGYSA
PIAVNGYDHMKKKNGMWRILKRAEQKYGYEGLYKIMQKNWRFILPMIKDNQTNVDNLIDV
FTVRTMTEFYFDKPFDLSPKVFLLWFLRGLIPKNKPNLKLDALGKQVTKQMYAYIDSTPW
AKKVLPEILKEDGRDADTLKGEALQLAFIFSVFSLRSGMSSTIPLFLNLNDQTKDAILKE
VNAFHGSNQTVGQKLKDLDVLDRFVIEVWRYHTPVSLVFGKAKK
Unnamed CYP74 clan seq Hydractinia echinata
CO720793.1
32% to CYP443D1 XM_001636310Nematostella vect
N-term
MWNIMKMNRRGHQFFLNKMLKHNSSVYKVKCEEERIMICDHVGLQVLYDPDKVDKMLGFG
TMDYNPVILRNYVPAMFSNDDEHRHKKDVALQVVKHVTSTHSVEDLNEIIAEQFRSLK
PIENLNKKSAMTLDFENVIQKAVASVI
CYP3001A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001A5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001A6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001A7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B8 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001B9 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001C1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001C2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001D1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001D2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001D3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001D4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001D5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001E1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001F1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001F2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001G1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001G2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001H1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001H2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001J1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001K2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001L1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001L2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001L3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001L4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001M1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001M2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001M3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001M4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001N1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001N2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001N3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001N4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001P1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001P2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001P3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001Q1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001Q2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001Q3v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001Q3v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001R1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001R2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3001S1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3002A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3002A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A5-de1b Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A8P Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3003A9 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004C1v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004C1v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004C2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004C3P Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004D1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3004D2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A8 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A9 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A10 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A11 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A12 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A13 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A14 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A15v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A15v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A16 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A17 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A18 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A19 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A20 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3005A21 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006C1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006D1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006E1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006F1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006G7P Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3006H1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3007A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3007A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3007A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3007A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3007A5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3008A1v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3008A1v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3008A1v3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3008A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3008A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3008B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A5 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A8 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A9 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A9-de11b12b Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A10 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A10-de6b Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A11 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A12 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A13 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009A14 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009B2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009B3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009C1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D2v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D2v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D5P Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D6 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D7 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3009D8 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3010A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3010B1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3011A1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3011A2v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3011A2v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3011A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A1v1 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A1v2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A1v3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A1v4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A2 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A3 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3012A4 Ixodes scapularis (deer tick, arthropod, arachnid, ecdysozoa)
CYP3013 to CYP3015 Chronimidae sp.
CYP3016 to CYP3019 Meligethes aeneus (pollen beetle)
CYP3020 to CYP3041 Tigriopus japonicus (marine copepod)
CYP3042 to CYP3049 Brachionus koreanus (monogont rotifer)
CYP3050A1 Schistosoma mansoni (Platyhelminthes)
No accession number
David Williams
Submitted to nomenclature committee April 24, 2013
24% to CYP370A12 Daphnia pulex
23% to CYP330A1 Carcinus maenas (shore crab)
probable CYP2 clan member
Note: three digit names for lower eukaryotes are reserved from CYP501-CYP699.
CYP501 Candida albicans
no accession number see What's New of Dec. 2 on the C. albicans
server CYP99
265137G06.x1.seq from the Candida albicans genome project
265137G06.x1.seq
3rd frame on complementary strand.
last 50 bases not reliable sequence. EXXR motif shows as DTLR with
the
D probably wrong here.
This sequence is incorrectly named as CYP99 which is a plant sequence.
CYP501A1v1 Candida albicans
GenEMBL XM_706447
allele of CaO19.8987 XM_706426.1 (5 aa diffs)
best hits are to CYP504, but only low 30% range
in CYP64 clan
putative phenylacetate hydroxylase
MLSSIRWDEALLILLNYLNDYPVTITCFLVLLIIALGIAIDYII
TPKEIANIFPIPGELPFIGHLHLILENPALIYLTWSKLYNQSIFQIRIGNKRVVVVNS
FDDVVGLWVNHSCQNNSRPLSYTFHDLVSAIQGFTIGSTPASLTFQKKKKTISQYLNK
RQIELKSDTINRQINIMIGELWKRDIEFEDINLLPYFQKFVLQTAIFIGYGIELDCYK
EHSQFCQEIIDIENKIIRLRSPISNLQDSIPLLRIMPRWFNNSEIARMCGERRNSYMN
KLYQQLQQGLAEDLPQYKNSILGDLITKTTNTQNNNDDSSDTNCTSHNNCLNEQEIQS
ICLTLISAGLDNTPLSLNYLFGILSHPKIGEHLQNRAIQDILEDSGGNIVLAWEKVSS
LQGQMTTNQQNPMNCQYIEALVLETLRHFTVLPLSLPRLTTKAIRYKDFVIPKETHLF
MNAYSANHDCQIFVNPYKFDPDRWLDPVSNSIKSQFLNFIINNNSKSSSGHGHQFKSL
HSHQHFAFGAGSRMCSGYNLVIKQMYVMIIKMLLIFEIHPPTNIKKLMELNPFKNNSN
PKGTSFEPKTNHINLKFRKLPNYKSLHELVLHQS
CYP501A1v2 Candida albicans
GenEMBL XM_706426.1
allele of CaO19.1411 XM_706447 (5 aa diffs)
Gene sequence has no introns AACQ01000193.1, AACQ01000194.1
best hits are to CYP504, but only low 30% range
in CYP64 clan
putative phenylacetate hydroxylase
MLSSIRWDEALLILLNYLNDYPVTITCFLVLLIIALGIAIDYII
TPKEIANIFPIPGELPFIGHLHLILENPALIYLTWSKLYNQSIFQIRIGNKRVVVVNS
FDDVVGLWVNHSCQNNSRPLSYTFHDLVSAIQGFTIGSTPASLTFQKKKKTISQYLNK
RQIELKSDTINRQINIMIGELWKRDIEFEDINLLPYFQKFVLQTAIFIGYGIELDCYK
EHSQFCQEIIDIENKIIRLRSPISNLQDSIPLLRIMPRWFNNSEIARMCGERRNSYMN
KLYQQLQQGLAEDLPQYKNSILGDLITKTTNTQNNNDDSSDTNCTSHNNCLNEQEIQS
ICLTLISAGLDNTPLSLNYLFGILSHPKIGEHLQNRAIQDILEDSGGNIVLAWEKVSS
LQGQMTTNQQNPMNCQYIEALVLETLRHFTVLPLSLPRLTTKAIRYKDFVIPKETHLF
MNAYSANHDCQIFVNPYKFDPDRWLDPVSNSIKSQFLNFIINNNSKSSSGHGHQFKSL
HSHQHFAFGAGSRMCSGYNLVIKQMYVMIIKMLLIFEIHPPTNIKKLMELNPFKNNSN
PKGTSFEPKTNHINLKFRKLPNYKSLHELVLHQS
CYP501A2 Candida tropicalis MYA-3404 cont1.80
GenEMBL AAFN01000033.1
62% to 501A1 in CYP64 clan
putative phenylacetate hydroxylase
128977 MLLSIPWDQSLLTLLTYLDTHPIATIFTIILTILTIGILFDYCLSPKEIANIFSIPGDLP 128798
128797 FIGHLHLILDNPALIYLTWYKLYNKLVFQIRIGNKRVVVVNSFDDVVGLWINHSCQNNSR 128618
128617 PLSYTFHGLVSALQGFTVGSTPASLTFLRKKKVISLCLRKKEIDEKVCLIDNEICVMIKE 128438
128437 IIKKKDISTDVNMLPYLQKFILKTAILMSYGIELDCYNKDVKLCQEIITVENNIIRLRSP 128258
128257 ISNLQDSVPFLRLIPWFNNREFALRCGNRRNKYMDQLYNRLQNGLAENDPNIANSILGQ 128081
128080 LILNNDNNNSNSLTSQEIQSICLTLVSAGLDNTPLNLNYLIGILSQ 127943
127942 PRIGKIFQDKAIKDILNHANGDIIQAWNQLNEENRDCKYIQALILETLRH 127793
127792 FTVLPLSLPRLTTKPIYYKNFMIPKNTHMFMNAYSANHDELIFKNPFKFDPERWLDSETN 127613
127612 EIKSKILATTSSSSSSTHHGGGNGINVQNFHFAFGAGSRMCSGYNLVMKEMYMMIIKL 127439
127438 LLLFEINPPDNNNNNGKYLMEMNPFVNNLNPRGTSFEPRIHNIKLQYRKLPNYETLHEIVLK* 127250
CYP501A3 Candida dublinensis
89% to CYP501A1v1 Candida albicans
See fungal pages for sequence
CYP501A4 Candida parapsilosis
50% to CYP501A2 Candida tropicalis
See fungal pages for sequence
CYP501B1 Candida lusitaniae
38% to CYP501A3 with some indels removed
See fungal pages for sequence
CYP501C1 Candida guilliermondii
43% to CYP501A2
See fungal pages for sequence
CYP501D1 Debaryomyces hansenii
GenPept CAG86740.1
45% to CYP501A2 Candida tropicalis
See fungal pages for sequence
CYP501D2 Pichia stipitis
JGI gene model e_gwh1.7.1.272.1
56% to CYP501D1 Debaryomyces hansenii
See fungal pages for sequence
CYP502A1 Coprinus cinereus(homobasidiomycete mushroom)
GenEMBL AB013443
Muraguchi,H., Takemaru,T. and Kamada,T.
The eln2 gene of the mushroom Coprinus cinereus, a dominant
mutation of which renders the fruit-body dumpy, encodes a
cytochrome P450 enzyme
Unpublished (1998)
gene name eln2
CYP502B1 Phanerochaete chrysosporium (white rot fungus)
JGI gene model pc.5.187.1
MDTVLVGLFVALALYAWSRSSKRSALPVPPGPKPVPLLGNIFDLTAKELWLRVTGWSKQY
DIVYIHLLGQGLVFCNTYEVAQDLLEKKGSIYSDKCGCQNMVAFTRYGDFARRQRKLMNT
AFGISAVKRYRPLLANESVLLLKRILADPQDYMGYIRRYAGGLTLQSVYGYRVETNDDPL
LELGTECVDILSNKIASGGGIWPVDIFPFLQHLPTWFPGAGFKRKAAVWRAKMEEFVDKP
YEMVLERMRSGATVPCFVTTLLEEARDEKGGAVDAQRDFDIRWTANSMYSASMDTTITVV
QLFLLAMILHPEVLRKAQAELDAVVGPARLPTFADRPALPYLDAVMSEVLRWGVPVPLGL
PHRLMEDDVYRGTHLRAGTLVFANIWNMLRNEAIWAQPDVFRPERFLEPVDEATAKRRDP
RPYVFGFGRRRCPGLHLIEESLWIVMATLLATTDILAEKDESGKPVMPHVDFTNSLVVPF
STPAPFKCDIRPRSEQALQLVRLAE
CYP502B2 Postia placenta (brown rot basidiomycete fungi)
CYP502B3v1 Postia placenta (brown rot basidiomycete fungi)
CYP502B3v2 Postia placenta (brown rot basidiomycete fungi)
CYP502B4 Postia placenta (brown rot basidiomycete fungi)
CYP502B5 Postia placenta (brown rot basidiomycete fungi)
CYP502B6 confidential basidiomycete
CYP503A1 Gibberella fujikuroi (rice fungal pathogen)
GenEMBL Y17243 (3090bp)
Malonek S, Bomke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P,
Tudzynski B. (2005) Distribution of gibberellin biosynthetic genes and
gibberellin production in the Gibberella fujikuroi species complex.
Phytochemistry. 2005 Jun;66(11):1296-1311.
Malonek S, Rojas MC, Hedden P, Gaskin P, Hopkins P, Tudzynski B. (2005)
Functional characterization of two cytochrome P450 monooxygenase genes,
P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium
proliferatum (Gibberella fujikuroi MP-D).
Appl Environ Microbiol. 71, 1462-1472.
p450-4 gene
CYP503A1 Gibberella proliferatum (teleomorph sexual form)
Fusarium proliferatum (anamorph asexual form)
GenEMBl AJ628021
Malonek S, Bomke C, Bornberg-Bauer E, Rojas MC, Hedden P, Hopkins P,
Tudzynski B. (2005) Distribution of gibberellin biosynthetic genes and
gibberellin production in the Gibberella fujikuroi species complex.
Phytochemistry. 2005 Jun;66(11):1296-1311.
Malonek S, Rojas MC, Hedden P, Gaskin P, Hopkins P, Tudzynski B. (2005)
Functional characterization of two cytochrome P450 monooxygenase genes,
P450-1 and P450-4, of the gibberellic acid gene cluster in Fusarium
proliferatum (Gibberella fujikuroi MP-D).
Appl Environ Microbiol. 71, 1462-1472.
Ortholog to Gibberella fujikuroi CYP503A1
ent-kaurene oxidase"
MNKSNSMNNTSLERLFQQLVLGLDGIPLMDVHWLIYVAFGAWLC
SYVIHVLSSSSTVKVPVVGYRSVFEPTWLLRLRFVWEGGSIIGQGYNKFKDSIFQVRK
LGTDIVIIPPNFIDEVRKLSQDKTRSVEPFINDFAGQYTRGMVFLQSDLQNRVIQQRL
TPKLVSLTKVMKEELDYALTKEIPDMKDDEWVEVDISSIMVRLISRISARVFLGPEHC
RNQEWLTNTAEYSESLFITGFILRVVPHILRPFIAPLLPSYRTLLRNVSSGRRVIGDI
IRSQQGDGNEDILSWMRDAATGEEKQIDNIAQRMLILSLASIHTTAMTMTHAMYDLCA
RPEYIEPLRDEVKGVVDASGWDKTALNRLHRLDSFLKESQRFNPVFLLTFNRIYHQSM
TLSDGTNLPSGTRIAVPSHAMLQDSAHVPGPTPPTEFDGFRYSKIRSDSNYAQKYLFS
MTDSSNMAFGYGKYACPGRFYASNEMKLTLAILLLQFEFKLPDGKGRPRNITIDSDMI
PDPRARLCVRKRSLRDE
CYP503A2 Aspergillus niger
JGI gene model e_gw1.4.275.1|Aspni1
54% to CYP503A1
See fungal pages for sequence
CYP503B1 Aspergillus nidulans
AN1598.1
45% to 503A1 in 54 clan
revised 7/18/07
MDNYTWHSGTLIPSDSPSSIDRSQLYLEILGVLSVVYLLQT
LVAYSKSFKAPFVGFRFWYEPKWLVGLRFSQGALAQVNEGYAKYKNAMFK
VARNDSDILVIPNKYVEELRSLPDEKISAIRAHIKNLLGKYSTTLILLES
DLHTRMLQTKLTPNLGSFIEVIESELLFAMDQEIPANLDDWQSVNVFHIV
LRIVARISARVFLGVPACRNEEWLQTSIHYTENVFATVMLLRRFPKWMHP
IVGHLLPSYWAIHRNLRTAKRIISPMVRQRRAEEAKRNPDYVKPNDLLQW
MMDGANENDGQPDKLAHRQLLLSLASIHTTTMAAAHCFYDLCQHPEYFEP
LREEINDVIAQDGGWKKTTLNKMRKLDSFLKESQRINPPSLLAFNRIVSE
DLTLSDGTLLPKGTHFSMPSAAILQDNGVEPGADQFDGFRYYKKRLNPEE
ANKHQFAMTDNNNLHFGHGKYSCPGRFFASNEIKIIMAHLLTDYEFKYPR
GATRPRNLTADENLYPDPSARLLMRRRVVAPPQASITPQLVSA*
CYP503B2 Uncinocarpus reesii
54% to CYP503B1
See fungal pages for sequence
CYP503B3 Coccidioides immitis
74% to CYP503B2 Uncinocarpus reesii
See fungal pages for sequence
CYP503B4 Neosartorya fischeri
92% to CYP503B1 A. nidulans
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for sequence
CYP503C1 Aspergillus niger
JGI gene model e_gw1.10.655.1|Aspni1
42% to CYP503B1
See fungal pages for sequence
CYP503D1 Mycosphaerella graminicola
51% to CYP503A1, 45% to CYP503B1
alt N-term from JGI model e_gw1.1.487.1|Mycgr3
See fungal pages for sequence
CYP503E1 Metarhizium anisopliae var. anisopliae Ma23
CYP504A1 Aspergillus nidulans (fungus)
GenEMBL AJ132442
Mingot JM, Penalva MA, Fernandez-Canon JM
Disruption of phacA, an aspergillus nidulans gene encoding a novel
cytochrome P450 monooxygenase catalyzing phenylacetate
2-hydroxylation, results in penicillin overproduction.
J Biol Chem 274, 14545-50 1999
gene name phacA
CYP504A2v1 Penicillium chrysogenum strain Wisconsin 54-1255
GenEMBL AF056978.1
phenylacetate hydroxylase (pahA) gene
Rodriguez-Saiz M, Barredo JL, Moreno MA,
Fernandez-Canon JM, Penalva MA, Diez B.
Reduced function of a phenylacetate-oxidizing cytochrome p450 caused
strong genetic improvement in early phylogeny
of penicillin-producing strains.
J Bacteriol. 2001 Oct;183(19):5465-71.
Rodriguez-Saiz,M., Barredo,J.L. and Diez,B.
The phenylacetate hydroxylase encoding gene from Penicillium
Chrysogenum
Unpublished 1999
CYP504A2v2 Penicillium chrysogenum strain NRRL1951
GenEMBL AF057558
Rodriguez-Saiz M, Barredo JL, Moreno MA,
Fernandez-Canon JM, Penalva MA, Diez B.
Reduced function of a phenylacetate-oxidizing cytochrome p450 caused
strong genetic improvement in early phylogeny
of penicillin-producing strains.
J Bacteriol. 2001 Oct;183(19):5465-71.
Rodriguez-Saiz,M., Barredo,J.L. and Diez,B.
The phenylacetate hydroxylase encoding gene from Penicillium
chrysogenum NRRL1951
Unpublished 2000
1 amino acid difference to CYP504A2v1
CYP504A2v3 Penicillium chrysogenum strain NRRL1951
GenEMBL AF057559
Rodriguez-Saiz M, Barredo JL, Moreno MA,
Fernandez-Canon JM, Penalva MA, Diez B.
Reduced function of a phenylacetate-oxidizing cytochrome p450 caused
strong genetic improvement in early phylogeny
of penicillin-producing strains.
J Bacteriol. 2001 Oct;183(19):5465-71.
Rodriguez-Saiz,M., Barredo,J.L. and Diez,B.
The phenylacetate hydroxylase encoding gene from Penicillium
notatum
Unpublished 2000
Note: the species in the title does not match
the species in the Genbank entry
2 amino acid differences to CYP504A2v1
CYP504A3 Aspergillus terreus
GenEMBL AF141925.1
Kennedy,J., Auclair,K., Kendrew,S.G., Park,C., Vederas,J.C. and
Hutchinson,C.R.
Accessory Proteins Modulate Polyketide Synthase Activity During
Lovastatin Biosynthesis
Science 284, 1368-1372 1999
lovastatin biosynthesis gene cluster
72% identical to CYP504A2v1
CYP504A3v2 Aspergillus terreus
AAD34565.1
6 aa diffs to 504A3v1
1 MTLQIIVIAA TAVIYFLTRY FNRTDIPKIK GIPEIPGVPI FGNLIQLGVK HATVARKWSK
61 EFGPVFQARL GNRRVIFANT FESTRQLWIK EQSSMISRPT FHTFHGVVSS SQGFTIGTSP
121 WDESCKRRRK AAATALNRVA VQSYMPIIDL ESMASIKELL KDSQGGKIDI NPTPYFQRFA
181 LNTSLTLNYG YRIEGNVNDQ LLREICEVQR GVANLRSTSN NWQDYVPLLR LFSNRSNQAK
241 HLRARRDKYM AFLFDILKDR MAKGTDKPCI TGNILKNPET KLTDAEIKSI CLTMVSAGLD
301 TVPGNLIMGI AYLSSEDGQR IQQKAYEEIM SVYPNGDAWE RCLVEEKVPY ITALVKETLR
361 FWTVMPICIP RVNIKEVIYN GARIPAGTTF FMNAWAANYD EDHFDMPNRF LPERYLEPSE
421 GFGTPHYSFG AGTRMCAASH LASRELYTVF LRFIVAFTIE PAQNPADMPV LDAIECNATP
481 TSMTTEPKPF KVGFKPRDET SLRRWIAESE ERTKEL
CYP504A4 Magnaporthe grisea
MG04684.4 71% to CYP504A1 AACU01001145 cont2.876
See fungal pages for sequence
CYP504A5 Fusarium graminearum
AACM01000162.1 revised GC boundary at KLNE old name = 504A3
See fungal pages for sequence
CYP504A6 Nectria haematococca (Fusarium solani group)
e_gw1.24.52.1 same gene as fgenesh1_pg.scaffold_24000130
Necha1/scaffold_24:331011-332725
72% to CYP504A1 Aspergillus nidulans (probable ortholog)
85% to 504A5 Fusarium graminearum
See fungal pages for sequence
CYP504A7 Aspergillus fumigatus Af293
GenEMBL XP_748171.1 also
phenylacetate 2-hydroxylase (predicted)
85% to 504A1
MAQTIVLAVLAAVYLLIRYLNRTDIPKIKGLPEIPGVPIFGNLLQLGDRHATVAARWAKKYGPVFQVRMG
NKRIVFANSFESVKQLWIKDQSALISRPTFHTFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAV
QSYMPIIDLESTASIKELLKDCRNGAVDINPTAYFQRFALNTSLTLNYGFRIEGNVDDALLREIVDVERG
VSNFRSTSNNWQDYIPLLRIFPKTNREAEEFRVRRDKYLTFLLDMLKERIAKGTDKPCITGNILKDPEAK
LNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEAGQRIQQKAYEEILKVYPNGDAWEKCLVEEKVPYI
TALVKETLRFWTVIPICLPRESTKDIVYNGATIPAGTTFFMNAYAADYDDEHFKMPDKFIPERYLDVSEG
SGTPHYGYGAGSRMCAGSHLANRELYTAYIRLITAFTMHPARDPADQPILDAIECNAIPTALTTEPKPFK
VGFKPRDASKLQQWIAESDERTKEL
CYP504A7 Neosartorya fischeri
XM_001266358.1, XP_001266359.1
77% to 504A3, 97% to CYP504A7 Aspergillus fumigatus
NFIA_040380
Name revised from CYP504A10
MAQTIVIAVLAAVYFLIRYLNRTDIPKIKGLPEIPGVPVFGNLL
QLGDRHATVAAKWAKKYGPVFQVRMGNKRIVFANSFESVKQLWIKDQSALISRPTFHT
FHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLEATASIKELLK
DCRNGAVDINPTAYFQRFALNTSLTLNYGFRIEGNVDDALLREIVDVERGVSNFRSTS
NNWQDYIPLLRIFPKTNREAEEFRVRRDKYLTFLLDMLKERIAKGTDKPCITGNILKD
PEAKLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQQKAYEEIMKVYPN
GDAWEKCLVEEKVPYVTALVKETLRYWTVIPICLPRESTKDIVYNGATIPAGTTFFMN
AYAADYDDDHFKMPDKFIPERYLDVSEGSGTPHYGYGAGSRMCAGSHLANRELYTAYI
RLITAFTMHPARDPADQPILDAIECNAIPTALTTEPKPFKVGFKPRDTSKLQQWIAES
DERTKEL
CYP504A8 Aspergillus oryzae
GenEMBL BAE58419.1
86% to 504A1, 45% TO 504B6
MSLQTIAIAAIAVAYFIIRYLNRTDVPKIKGIPEIPGVPLFGNLLQLGDQHATVAGKWAKKFGPVFQVRM
GNKRVVFANSFDSVRQLWIKDQAALISRPTFHSFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPA
VQSYMPIIDLEATASIKELLKDSQNGTVDVNPTAYFQRFALNTSLTLNYGFRIEGNVDDELLKEIVDVER
GVSNFRSTSNNWQDYIPLLRIIPKMNREAEEFRVRRDKYLTYLLDILKDRIAKGTDTPCITGNILKDPEA
KLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQQKAYDEIMKVYPDGDAWEKCLVEEKVPY
VSALVKETLRFWTVIPICLPRVNIKEIEFNGAKIPAGTTFFMNAWAADYDEDHFKMPEKFLPERYLEVSE
GSGTPHYGYGAGSRMCAGSHLANRELYTAYIRLITAFTMHPAQNPADRPILDAIECNEIPTALTTEPKPF
KVGFKPRDAPKLQQWIMESDERTKDL
CYP504A8 Aspergillus flavus
99% to CYP504A8 Aspergillus oryzae
See fungal pages for sequence
CYP504A9 Aspergillus terreus
XM_001218406.1 XP_001218407.1
79% to 504A3
MALQTLAIAAAAVVYFIIRYFNRTDVPKIKGLPEIPGVPIFGNL
LQLGDKHATVAGAWAKKYGPVFQVRMGNKRVVFANSFDSVRQLWIKDQSALISRPTFH
TFHSVVSSSQGFTIGTSPWDESCKRRRKAAATALNRPAVQSYMPIIDLECTASIRELL
KNSQGGTVDLNPAPYFQRFALNTSLTLNYGFRIEGNVDDQLLREIVDVERGVSNFRST
SNNWQDYIPLLRIFPKMNTEAEEYRVRRDKYLTYLLDILKDRIAKGTDKPCITGNILK
DPEAKLNEAEVKSICLTMVSAGLDTVPGNLIMGIAYLASEDGQRIQEKAYDEIMKVYP
NGDAWEKCLVEEKVPYITALVKETLRFWTVIPICLPRESTKEIVYNGAKIPAGTTFFM
NAWAADYDEDHFKMADRFIPERYLEQSEGAGTPHYGYGAGSRMCAGSHLANRELYTAF
IRLITAFTMHPAQNKEDLPVLDAIECNAIPTALTTEPKPFKVGFKPRDAALLEKWIAE
SDERTKEL
CYP504A11 Aspergillus clavatus NRRL 1
XP_001276373.1
74% to 504A3
1 MTLQTLAFAV VAAVYLVIRY LNRTDVPKIK GIPEIPGVPL FGNLLQLGDQ HATVAAKWAK
61 QYGPVFQVRM GNRRIVFANS FDSVRQLWIK DQSALISRPT FHTFHSVVSS SQGFTIGTSP
121 WDESCKRRRK AAATALNRPA VQSYMPIVDL EATASIKELL KNGQNGAVEL NPTAYFQRFA
181 LNTSLTLNYG FRIEGNVDDQ LLREIVDVER GVSNFRSTSN NWQDYIPLLR ILPKTNREAE
241 EFRERRDKYL TYLLDILKDR IAKGIDKPCI TGNILKDPEA KLNEAEVKSI CLTMVSAGLD
301 TVPGNLIMGI AYLASEDGQR IQQKAYDEIM KVYPNGEAWE KCLVEEKVPY VTALVKETLR
361 FWTVIPICLP RESTKDIVYN GATIPAGTTF FMNAYAADYD ADHFKFPEKF IPERYLDVGE
421 GSGTPHYGYG AGSRMCAGSH LANRELFTAY IRLITAFTMH PARDPTDRPI LDAIECNDIP
481 TALTTEPKPF KVSFKPRDAK TLQRWIEESD ERTREL
CYP504A12 Coccidioides immitis RS
XP_001243121.1
71% to 504A3
1 MGYQTIAIAV VAVVYFVIKQ LNKTDIPKIK NLPEIPGVPM FGNLIQLGDS HAKKAQDWVK
61 KYGEVFQVRL GNKRIIFANT FDSVKHFWIT HQSSLISRPT LHTFHTVVSS SQGFTIGTSP
121 WDESCKRRRK AAATALNRPA VQSYMPIIDL ESTVSIKELL NDSKDGTVDV DPNPYFQRFA
181 LNTSLTLNYG IRIDGSIEDE LLKEICHVER VVSNFRSTSN NWQDYIPLLR LWPSRNNEAK
241 EFRERRDRYL SLLLDMLRDR IAKGTDKPCI TGNILKDPEA KLNEAELKSI CLTMVSAGLD
301 TVPGNLIMGI AYLASAHGQE IQERAYQEIM KVYPDGDAWE RCLVEEKVPY ITAFVKEVLR
361 FWTVIPICLP RVSIKDIEYK GATIPAGTTF FMNAYAADYD ENHFKNPYEF RPERYLNVSD
421 GAGTPHYAYG AGSRMCAGSH LANRELYTAF LRLISAFRIV PAKNRADDPI LDCLEAGINK
481 CALTLDPKQF KVGFKVRDRA KLDAWIQGSD ERTKDL
CYP504A13 Phaeosphaeria nodorum SN15
EAT85524.1
64% to 504A3
1 MTIPLYVAGV AVLGFYLYRL LYGTDKPHIK GLPEVPGLPL FGSLVELGTN HAKVAQGWAK
61 KYGPVFQVRM GNRRIVFANS FDSVRHLWIT HQSALISRPT LHTFHTVVSS SQGFTIGTSP
121 WDESLKNRRK AAGTALNRPA VQSYMPLIDL ESTVSIRELL NDSKGGELDI DPRAYWQRYA
181 LNTSLTLNYG FRIDGDKDAP LLKEICDVER GVGNFRSTSN NWQDYVPLLR LFPSQSNEAK
241 KFRDRRDVYM NKLLDTLLEK IEKGTDKPCI TGNIIKDPDA KLNRAELKSI CLTMVSAGLD
301 TVPGNLIMGI AQLATPSGQS IQRRAHAEIL KVYPNNDAWH KCLEEEKIPY ITALYKEILR
361 YWTVIPISLP RQSIKDIEYN GVTFPAGTTF YMNAYAADYD DTHFSDPYTF NPERYLDVPD
421 GTGTPHYGYG AGSRMCIGSH LANRELYTAF VRLISAFEFT EPVDERDKPI MDCLEANAIP
481 TSLTLEPKYF KVGFKPRDRA LLEKWLGESE ERTRELKGMG K
CYP504A14 Gibberella moniliformis
partial cDNA DR661198 87% to 504A3
MSDQVIYLAIIIGLYMLYK LANSTDQPKIKGIPEIPGVPLFGNLIQLGTDHARVA
QKWAKKYGPVFQTRLGTKRVIYVNSYEAVKHFWITHQSALISRPMFHTFHSVVSSSQGFT
IGTSPWDESCKNRRKAAATALNRPAVQSYMPILDLESLVSIEELLNDCKDGSKDLDPSPY
FARFALNTSLTLNYGFRIDGDVNSELLHEITYVEREISNFRSTSNNWQDYVPLLRLWGAQ
NSSAEEFRVRRDKYLSDLLANLKSRIDNGTDKPCITGNILKDPTAKLNDAEIQSICLTMV
SAGLDTV
CYP504A15 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_7000252|Aspni1
88% to CYP504A8
See fungal pages for sequence
CYP504A16 Mycosphaerella graminicola
67% to CYP504A12 Coccidioides immitis
See fungal pages for sequence
CYP504A17 Yarrowia lipolytica
GenPept CAG77765.1
49% to CYP504A6 Nectria haematococca
See fungal pages for sequence
CYP504A18 Uncinocarpus reesii
94% to CYP504A12 Coccidioides immitis
See fungal pages for sequence
CYP504A19 Histoplasma capsulatum G217B
ABBT01000061.1 Ajellomyces capsulatus G217B
80% to CYP504A12 Coccidioides immitis
See fungal pages for sequence
CYP504A20 Fusarium oxysporum
85% to CYP504A5 Fusarium graminearum
See fungal pages for sequence
CYP504A20P Fusarium verticillioides
96% to CYP504A20 Fusarium oxysporum = ortholog
with 3 frameshifts
See fungal pages for sequence
CYP504A21 Metarhizium anisopliae var. acridum Ma102
CYP504A21 Metarhizium anisopliae var. anisopliae Ma23
CYP504A22 Grosmannia clavigera
CYP504B1 Aspergillus nidulans (fungus)
No accession number
Jose M. Fernandez-Canon
61% to 504B3
43% identical to CYP504A1, CYP504A2 and CYP504A3
submitted to nomenclature committee Feb. 24, 2003
revised sequence sent Sept. 21, 2005 with changed C-term
CYP504B2 Magnaporthe grisea
MG03352.4 63% to 504B1 Aspergillus nidulans
AACU01000699 cont2.663
See fungal pages for sequence
CYP504B3 Fusarium graminearum
FG06447.1 AACM01000259 FGcontig1.259_scaffold4
See fungal pages for sequence
CYP504B4 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.24.45.1
Necha1/scaffold_24:269356-271018
79% to 504B3 F. gram.
43% to e_gw1.24.52.1, 66% to 504B1 Aspergillus nidulans
See fungal pages for sequence
CYP504B5 Aspergillus fumigatus Af293
GenEMBL XP_752247.1 also EAL90209.1
phenylacetate hydroxylase predicted
68% to 504B4
MAIAAAVSSLQQNVLRHPLQSLAITALVVPIIYIIINEFIRASARVPGFKGPRGLPLIGNLAQIRKNAAE
QYRIWSKTYGPVYQIQLGNIPIIVVNSAAAAKILFGQNAQALSSRPEFYTFHRIVSNTAGTTIGTSPYSE
SLKRRRKGAASALNRPSVESYVSHLDVETKAFVAELLKYGNGGKTPVDPMAMIQRLSLSLSLTLNWGVRV
ASQEEDLFNEITHVEEEISKFRSTTGNLQDYIPLLRLNPFSTNSRKAKEMRDRRDRYLNALNRDLDDRME
KGIHKPCIQANVILDKEAKLNKEELISISLTMLSGGLDTITTLVAWSFCLLSRRPDIQEKAAQAIQDMFS
QDEPLCDAQDDQKCAYVAALVRECLRYYTVLRLALPRTSIKDITYDGKVIPKGTVFFLNSWACNMDPEVW
NDPEEFRPERWFEQPDAPMLTYGIGYRMCAGSLLANRELYLVFMRTLNSFHIEPHDDVDWHPINGNSDPT
SLVAIPKKYKVRFVPKNEQALTRALA
CYP504B5 Neosartorya fischeri
98% to CYP504B5 Aspergillus fumigatus = ortholog
See fungal pages for sequence
CYP504B6 Aspergillus oryzae
GenEMBL BAE56546.1
82% to 504B1
MAITATLFSIQKSLIHTPLQSIAIAALFTSCLYFIVNEFIRAFSRVPGFKGPRGLPLIGNIAQIRKNAAE
QYRIWSKTYGPVYQIQLGNIPVIVVNSAVSAKAIFGQNAQALSSRPEFYTFHK
IVSNTAGTTIGTSPYSD
SLKRRRKGAASALNRPSVESYVSHLDAESKAFVAELLKYGEGGNVPVDPMAMIQRLSLSLALTLNWGVRV
VSQEEDLFNEITHVEEEISKFRSTTGNLQDYIPLLRLNPFNTNSKKAKEMRDRRDKYLNGLNRDLDDRME
KGIHKPCIQANVILDQEAKLNSEELTSISLTMLSGGLDTVTTLVAWSIGLLAKRPDIQDKAAEAILNMYG
PNQPMCDAADDQRCAYVAALVRECLRYFTVLRLALPRTSIRDITYGGNIIPKGTVFFLNSWACNMDPDTW
SDPEEFRPERWLEQPDAPLFTYGLGYRMCAGSLLANRELYLIFMRTINSFRIEPYDEIDWHPVHGNADPT
SLVAIPKKYKV
RFIPRDNKVLEDVLGSAFSLKRVI
CYP504B6 Aspergillus flavus
100% to CYP504B6 Aspergillus oryzae
See fungal pages for sequence
CYP504B7 Aspergillus niger
JGI gene model estExt_fgenesh1_pm.C_30542|Aspni1
85% to CYP504B5
See fungal pages for sequence
CYP504B8 Uncinocarpus reesii
77% to CYP504B5
See fungal pages for sequence
CYP504B9 Coccidioides immitis
91% to CYP504B8
See fungal pages for sequence
CYP504B10 Fusarium oxysporum
87% to CYP504B4 Nectria haematococca
See fungal pages for sequence
CYP504B10 Fusarium verticillioides
98% to CYP504B10 Fusarium oxysporum = ortholog
See fungal pages for sequence
CYP504B11 Fusarium oxysporum
63% to 504B9 Coccidioides immitis
FOXG_10783 revised with gc boundary at EXXR motif
No ortholog found in Fusarium verticillioides
See fungal pages for sequence
CYP504B12 Aspergillus clavatus
89% to CYP504B5
See fungal pages for sequence
CYP504B13 Aspergillus terreus
85% to CYP504B5
See fungal pages for sequence
CYP504B14 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_22000145
68% to CYP504B8 Uncinocarpus reesii
See fungal pages for sequence
CYP504B15 Metarhizium anisopliae var. acridum Ma102
CYP504B15 Metarhizium anisopliae var. anisopliae Ma23
CYP504C1 Ustilago maydis
GenEMBL XM_399039.1
in the CYP64 clan 46% to 504A1
See fungal pages for sequence
CYP504D1 Ustilago maydis
GenEMBL XM_402689.1
in the CYP64 clan 48% to 504C1
See fungal pages for sequence
CYP504E1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.40.25.1
Necha1/scaffold_40:1293-2938
86% to CYP504E2 Aspergillus nidulans (probable ortholog)
86% to AAJN01000191.1 Aspergillus terreus
72% to XM_654859.1 Aspergillus nidulans (pseudogene)
45% to e_gw1.24.52.1, 45% to 504A1 Aspergillus nidulans
46% to XM_743078.1 Aspergillus fumigatus
See fungal pages for sequence
CYP504E2 Aspergillus terreus
GenEMBL AAJN01000191.1
86% to 504E1
N-term exon not clear, does not match other related genes
MTTTHDTAFIPSLAYRIQDGQGSTILGIAGVIALLSYL (0)
189214 TTIATDIPFIKGLPEIPGAVPIFGHLLKLGDDHATVCEKWWRQYGHSVFQIRLGNTRAV 189390
189391 VVNSFEDCRKMLLGHQNAIIDRPTLYTFHGVISSTQGFTIGSSPWDASCRKKRKAAGTAL 189570
189571 GRPALRSYYPMFDLESYSIVRDLHRDSCDGEVELNVRPYIQRYALNTTLTLCYGIRMD 189744
189745 AVYDELLREILYVGSAISLLRSASENLQDYIPLLRYLPNNEKNARSKSLRERRDKYLDLL 189924
189925 LDKVRDMIKKGTDKPCISSAILKDEETKLNGVEVSSICLSLVSGGFETIPGTLTSAIGSL 190104
190105 STKEGQVWQDRAYEDIKRHYPDIRDAWTSCFVEEKVPYVNAIIKEAGRYYTVSAMSLPRK 190284
190285 TVTEVNWNGAIIPQKTMVLINAQAGNH (1) 190365
190412 DVDHFGPDGGKFDPERW
190463 LKTLDPPTERETSGLNHLSFGAGSRACSGQYIASRLLYAALVRILSSYKIVASETEPPNT 190642
190643 DYVDYNQFKTALVAIPRDFKVKLVPRDPGMTAECLETAELRTREHYKE* 190789
CYP504E3 Phaeosphaeria nodorum
GenEMBL AAGI01000160.1
68% to 504E1
MEVLHLLQSLYCTPLGYVSLLALFGFCVASIYK (0)
15789 LLTRTEVPYIRGIPEIPGALPVTGHLTQLGDDHATICEKWWRQYGHSVFQVRLGNTRAV 15613
15612 IVSSFQDCKKILVSNPQGLIDRPKLYTFHGVISSTQGFTIGSSPWDESCRNKRKAASTTL 15433
15432 SKGMLKNYYEMFDLESYCIVRDLQRDSKGSALEVSIRPYIQRYALNTTLTLCYGIRMDA 15256
15255 VYDDLLREILHVGSAISLLRSASENYQDYIPILRYLPNNEKNRRSKELRERRDKYLNELL 15076
15075 DKVRNMIDKGTEKPCISAAILKDEETRLTGVEVSSICLSLVSGGFETIPGTLVSCIGSLS 14896
14895 TPEGQKYQETAYQEISKVYPDLEDAWSREFEKENVPYLNAIVKEAGRYYTVSNMSLPRKT 14716
14715 MSDVRWGEAIIPKGTMVLINAQAGNH (1)
DVDYWGPDAGTFNPERWLEPPHPSSIPSIF
14497 TEKPTSSTSHLSFGAGSRSCPGAAIASKLISAALFRILSLYKIEASSTEPPNTDYVEYNA 14318
14317 IKSALVAIPRDFKIKLTPRDETGDLAREVLRMGEERTKNFYKE 14189
CYP504E4P Aspergillus nidulans add to nomen.
AN2347.3 76% to CYP504E2
MKTDYDITA*TVSLSQGYSAVLLFILVTLYLLYKYTLATDIPHIKN
LPVIPGALPIFGHLLKLGGDHATV*
EKWWRQYGHSVFQIRLANTRVVVVKSFDDCRKMLLSHQNALIDRPKLYTSYCVISSTQGYTIDSSPWDEPCRKKRK
AGTALGRPALRNY
HPMFDLESCCILR
TDLYRDSKDGEAEVSVRPYLQRYALNTTLTLCYGIRMDEV
YDEVLSEILYAGSAISLLHSAAENLQDYISLLRYVPNNEKKARSK
TRDRRDKYLDLLTRVRKMIERGTDKPCISAAILKVKE
(gap 40 aa)
QAWQDHAYEDIKRWYPDLQDTWTAAVTEERV
TYINAIIKEAARYYTVSSMSLPRK
VTEINWNGAIIPPKTMILINAQAGNR
DIDHLGPTGNRFNPER*LSS
CYP504E5 Aspergillus niger
JGI gene model gw1.9.669.1|Aspni1
84% to CYP504E1 aa 219-331
See fungal pages for sequence
CYP504E6 Aspergillus niger
JGI gene model e_gw1.112.2.1|Aspni1
84% to CYP504E2 aa 279-590
See fungal pages for sequence
CYP504E7 Mycosphaerella graminicola
JGI gene model gw.1.2625.1 revised N-term
71% to CYP504E1 Nectria haematococca
See fungal pages for sequence
CYP504E8P Mycosphaerella graminicola
JGI gene model gw1.9.803.1|Mycgr3 N-term piece
68% to 504E7
See fungal pages for sequence
CYP504E9P Mycosphaerella fijiensis
76% to CYP504E7 Mycosphaerella graminicola
synt_with_mycgr.1__200
See fungal pages for sequence
CYP504E10 Grosmannia clavigera
CYP504F1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_33000056
Necha1/scaffold_33:187197-188955
44% to CYP504B1 Aspergillus nidulans
See fungal pages for sequence
CYP504G1 Candida guilliermondii
38-39% to many CYP504 sequences,
also 39% to CYP5054A1 and 41% to CYP5054A2
See fungal pages for sequence
CYP504H1 Metarhizium anisopliae var. anisopliae Ma23
CYP504J1 Metarhizium anisopliae var. anisopliae Ma23
CYP505A1 Fusarium oxysporum
GenEMBL AB030037
Naoki Takaya and H. Shoun
P450foxy, a fused reductase-P450 similar to CYP102
CYP505A1 Fusarium oxysporum
98% to CYP505A1 Fusarium oxysporum AB030037,
only 13 aa diffs
See fungal pages for sequence
CYP505A1 Fusarium verticillioides
98% to CYP505A1 Fusarium oxysporum CYP505
See fungal pages for sequence
CYP505A2 Neurospora crassa
No accession number
Neurospora crassa sequence contig 1.388 (supercontig 50)
9a27.tfa_140cg@9A27 like P450foxy
58% identical to 505A1 over 505 aa N-term part
Neurospora crassa sequence contig 1.388 (supercontig 50) Length = 87086
MSSDETPQTIPIPGPPGLPLVGNSFDIDTEFPLGSMLNFADQYGEIFRLNFPGRNTVFVTSQALVHELCDEKRFQ
KTVNSALHEIRHGIHDGLFTARNDEPNWGIAHRILMPAFGPMAIQNMFPEMHEIASQLALKWARHGPNQSIKVTD
DFTRLTLDTIALCSMDYRFNSYYHDDMHPFIDAMASFLVESGNRSRRPALPAFMYSKVDRKFYDDIRVLRETAEG
VLKSRKEHPSERKDLLTAMLDGVDPKTGGKLSDDSIIDNLITFLIAGHETTSGLLSFAFVQLLKNPETYRKAQKE
VDDVCGKGPIKLEHMNKLHYIAAVLRETLRLCPTIPVIGVESKEDTVIGGKYEVSKGQPFALLFAKSHVDPAVYG
DTANDFDPERMLDENFERLNKEFPDCWKPFGNGMRACIGRPFAWQEALLVMAVCLQNFNFMPEDPNYTLQYKQTL
TTKPKGFYMRAMLRDGMSALDLERRLKGELVAPKPTAQGPVSGQPKKSGEGKPIS
Start of reductase part
IYYGSNTGTCETFAQRLASD
AEAHGFTATIIDSLDAANQNLPKDRPVVFITASYEGQPPDNAALFVGWLESLTGNELEGVQYAVFGCGHHDWAQT
FHRIPKLVDNTVSERGGDRICSLGLADAGKGEMFTEFEQWEDEVFWPAMEEKYEVSRKEDDNEALLQSGLTVNFS
KPRSSTLRQDVQEAVVVDAKTITAPGAPPKRHIEVQLSSDSGAYRSGDYLAVLPINPKETVNRVMRRFQLAWDTN
ITIEASRQTTILPTGVPMPVHDVLGAYVELSQPATKKNILALAEAADNAETKATLRQLAGPEYTEKITSRRVSIL
DLLEQFPSIPLPFSSFLSLLPPMRVRQYSISSSPLWNPSHVTLTYSLLESPSLSNPDKKHVGVATSYLASLEAGD
KLNVSIRPSHKAFHLPVDADKTPLIMIAAGSGLAPFRGFVQERAAQIAAGRSLAPAMLFYGCRHPEQDDLYRDEF
DKWESIGAVSVRRAFSRCPESQETKGCKYVGDRLWEDREEVTGLWDRGAKVYVCGSREVGESVKKVVVRIALERQ
KMIVEAREKGELDSLPEGIVEGLKLKGLTVEDVEVSEERALKWFEGIRNERYATDVFD
CYP505A2 Neurospora discreta
JGI gene model estExt_fgenesh3_pm.C_120016
95% to CYP505A2 N. crassa
See fungal pages for seq
CYP505A3 Aspergillus oryzae
GenEMBL AB078738
Masahiko Kaya
Aspergillus oryzae fatty acid hydroxylase
Submitted to nomenclature committee Jan. 22, 2002
58% to CYP505A2
55% to CYP505A1
a fused reductase-P450 similar to CYP102
CYP505A3 Aspergillus oryzae
GenEMBL BAC55896.1, BAE56963.1
MSTPKAEPVPIPGPRGVPLMGNILDIESEIPLRSLEMMADTYGPIYRLTTFGFSRCMISSHELAAEVFDE
ERFTKKIMAGLSELRHGIHDGLFTAHMGEENWEIAHRVLMPAFGPLNIQNMFDEMHDIATQLVMKWARQG
PKQKIMVTDDFTRLTLDTIALCAMGTRFNSFYSEEMHPFVDAMVGMLKTAGDRSRRPGLVNNLPTTENNK
YWEDIDYLRNLCKELVDTRKKNPTDKKDLLNALINGRDPKTGKGMSYDSIIDNMITFLIAGHETTSGLLS
FAFYNMLKNPQAYQKAQEEVDRVIGRRRITVEDLQKLPYITAVMRETLRLTPTAPAIAVGPHPTKNHEDP
VTLGNGKYVLGKDEPCALLLGKIQRDPKVYGPDAEEFKPERMLDEHFNKLPKHAWKPFGNGMRACIGRPF
AWQEALLVIAMLLQNFNFQMDDPSYNIQLKQTLTIKPNHFYMRAALREGLDAVHLGSALSASSSEHADHA
AGHGKAGAAKKGADLKPMHVYYGSNTGTCEAFARRLADDATSYGYSAEVESLDSAKDSIPKNGPVVFITA
SYEGQPPDNAAHFFEWLSALKGDKPLDGVNYAVFGCGHHDWQTTFYRIPKEVNRLVGENGANRLCEIGLA
DTANADIVTDFDTWGETSFWPAVAAKFGSNTQGSQKSSTFRVEVSSGHRATTLGLQLQEGLVVENTLLTQ
AGVPAKRTIRFKLPTDTQYKCGDYLAILPVNPSTVVRKVMSRFDLPWDAVLRIEKASPSSSKHISIPMDT
QVSAYDLFATYVELSQPASKRDLAVLADAAAVDPETQAELQAIASDPARFAEISQKRISVLDLLLQYPSI
NLAIGDFVAMLPPMRVRQYSISSSPLVDPTECSITFSVLKAPSLAALTKEDEYLGVASTYLSELRSGERV
QLSVRLSHTGFKPPTELSTPMIMACAGSGLAPFRGFVMDRAEKIRGRRSSGSMPEQPAKAILYAGCRTQG
KDDIHADELAEWEKIGAVEVRRAYSRPSDGSKGTHVQDLMMEDKKELIDLFESGARIYVCGTPGVGNAVR
DSIKSMFLERREEIRRIAKEKGEPVSDDDEETAFEKFLDDMKTKERYTTDVFA
CYP505A3 Aspergillus flavus
99% to CYP505A3 Aspergillus oryzae 4 aa diffs
See fungal pages for seq
CYP505A4 Magnaporthe grisea
MG05401.4 53% to CYP505A2 AACU01000504 cont2.993
See fungal pages for seq
CYP505A5 Magnaporthe grisea
MG01925.4 55% to 505A2 AACU01000373 cont2.362
See fungal pages for seq
CYP505A6 Magnaporthe grisea
MG10879.4 59% to 505A2 AACU01001802 cont2.2099
See fungal pages for seq
CYP505A7 Fusarium graminearum
FG01972.1 AACM01000107 FGcontig1.107_scaffold1
See fungal pages for seq
CYP505A8 Aspergillus nidulans
AN6835.1 55% to 505A1 505 clan
See fungal pages for seq
CYP505A9 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_12000374 [Necha1:90392]
Necha1/scaffold_12:985898-989367
77% to 505A7, 79% to CYP505A1 Fusarium oxysporum
See fungal pages for seq
CYP505A10P Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_160000001
Necha1/scaffold_160:4628-11288
74% to CYP505A9 pseudogene exon 1 only
MAETAPIPEPPSYPLIGNWGEFTTTPATDFNRLAVTY (1)
CYP505A11 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_53000030 [Necha1:96758]
Necha1/scaffold_53:84132-87603
59% to 505A7, 60% to 505A1
58% to fgenesh1_pg.scaffold_12000374
See fungal pages for seq
CYP505A12 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_23000101 [Necha1:93347]
Necha1/scaffold_23:253431-256834
57% to 505A7, 56% to 505A1
57% to fgenesh1_pg.scaffold_12000374
Note: unusual exon 1 codes for 2 amino acids, this matches with
other CYP505 sequences.
See fungal pages for seq
CYP505A13 Aspergillus fumigatus Af293
GenEMBL XP_754698.1 also EAL92660.1
fatty acid hydroxylase predicted
60% to 505A8
MSESKTVPIPGPRGVPLLGNIYDIEQEVPLRSINLMADQYGPIYRLTTFGWSRVFVSTHELVDEVCDEER
FTKVVTAGLNQIRNGVHDGLFTANFPGEENWAIAHRVLVPAFGPLSIRGMFDEMYDIATQLVMKWARHGP
TVPIMVTDDFTRLTLDTIALCAMGTRFNSFYHEEMHPFVEAMVGLLQGSGDRARRPALLNNLPTSENSKY
WDDIAFLRNLAQELVEARRKNPEDKKDLLNALILGRDPKTGKGLTDESIIDNMITFLIAGHETTSGLLSF
LFYYLLKTPNAYKKAQEEVDSVVGRRKITVEDMSRLPYLNAVMRETLRLRSTAPLIAVHAHPEKNKEDPV
TLGGGKYVLNKDEPIVIILDKLHRDPQVYGPDAEEFKPERMLDENFEKLPKNAWKPFGNGMRACIGRPFA
WQEALLVVAILLQNFNFQMDDPSYNLHIKQTLTIKPKDFHMRATLRHGLDATKLGIALSGSADRAPPESS
GAASRVRKQATPPAGQLKPMHIFFGSNTGTCETFARRLADDAVGYGFAADVQSLDSAMQNVPKDEPVVFI
TASYEGQPPDNAAHFFEWLSALKENELEGVNYAVFGCGHHDWQATFHRIPKAVNQLVAEHGGNRLCDLGL
ADAANSDMFTDFDSWGESTFWPAITSKFGGGKSDEPKPSSSLQVEVSTGMRASTLGLQLQEGLVIDNQLL
SAPDVPAKRMIRFKLPSDMSYRCGDYLAVLPVNPTSVVRRAIRRFDLPWDAMLTIRKPSQAPKGSTSIPL
DTPISAFELLSTYVELSQPASKRDLTALADAAITDADAQAELRYLASSPTRFTEEIVKKRMSPLDLLIRY
PSIKLPVGDFLAMLPPMRVRQYSISSSPLADPSECSITFSVLNAPALAAASLPPAERAEAEQYMGVASTY
LSELKPGERAHIAVRPSHSGFKPPMDLKAPMIMACAGSGLAPFRGFIMDRAEKIRGRRSSVGADGQLPEV
EQPAKAILYVGCRTKGKDDIHATELAEWAQLGAVDVRWAYSRPEDGSKGRHVQDLMLEDREELVSLFDQG
ARIYVCGSTGVGNGVRQACKDIYLERRRQLRQAARERGEEVPAEEDEDAAAEQFLDNLRTKERYATDVFT
CYP505A13 Neosartorya fischeri
97% TO CYP505A13 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP505A14 Aspergillus oryzae
GenEMBL BAE56245.1
61% TO 505A3
revised 3/19/2009
MEETKLIPIPEPRGLPLLGNILDVDSEAPEKSFQRLAETYGPIFRLNLAGASRVFISTYELVDEICDEER
FTKVVTAGLREIRNGVQDGLFTADYPGEDNWAIAHRVLVPAFGPLMIRAMYEDMYDIASQLALKWARQGS
SATIMANDDFTRLTLDTIALCSMGTRFNSFYSEDLHPFIKAVATLLQGSSDRTFRSTLLNNLPTRENKKY
WSDISLLRTLSQELVDARRNNPIDKKDLLNALILGQDLQTGQHLSDDSIINNMITFLVA (1)
GHETT
SATLTFLFYYLLKNPHAYQRAQEEVDTVVGQRKIIVEDLSKLPYIAASLRETLRLQAPVPLIAFHPHPTK
NHEDPVTLGKGKYALNNDEPVVLIMGKVHRDPKVFGDDAEEFKPERMLDKNFEDLPKNAWKPFGNGMRGC
IGRPFAWQEMLLVVAMLLQNLNFEMENPSYDLRIKQSLSIKPDGFQMKATLRRGLDAAKLASVLNSGGDL
LSHAPQILNGEYKPNTDLRFHLRPMHIFFGSNTGTCEALARRLAKDSMGYGFATRVESLNSAMENIPRDN
PVIFITATYEGQPPDNAAHFFEWLNGLKKAELDGVNYCVFGCGHHDWSATFLRIPKATNDLIEKHGGTRL
CDMGMADAANSDMFSDFDTWSELILWPAINLKFGRASSEGDVQSKSALHVDVSSSMRAFTLGLQLQEGYV
LENKLLTTPDVPAKRMLRFKLPPDTTYQCGDYLIVLPVNPAHVVCRAIRRFNISWDSMLTVRKPSHASDG
ITNMPLETPISAFELFSTYVELSQPASKRDLITLADAATTDTDAQAELQSLASSPNRFTEEVINNRLSPL
DILIRHPSINLPLSTFLEMLPPLRARQYSISSSPLASRSDCTITFSVLNSPHLSTENKRFVGVASTYLSE
LQAGDRVQISIRASNNKGFKPPLKEETPMIMACAGSGLAPFRGFIMDRAERIRGRGTELLSDDDHPEIGK
PARAILYIGCRTKGKDDIHASELDEWTRQGAVDVRWAYSRPTDRSQGRHVQDLLFEDRNELLELIDQGAR
IYVCGGMSVGQGIRQVFKDMFIERCREVLENGSDGDEDVAAEEYLDSLKTEERYATDVFT
CYP505A14 Aspergillus flavus
99% to CYP505A14 Aspergillus oryzae
See fungal pages for seq
CYP505A15 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_7000162|Aspni1
72% to CYP505A13
See fungal pages for seq
CYP505A16 Fusarium oxysporum
57% to CYP505A12 Nectria haematococca
no ortholog in F. verticillioides
See fungal pages for seq
CYP505A17 Fusarium oxysporum
86% to CYP505A11
See fungal pages for seq
CYP505A18 Aspergillus clavatus
87% to CYP505A13 Aspergillus fumigatus
See fungal pages for seq
CYP505A19 Aspergillus terreus
65% to CYP505A18
See fungal pages for seq
CYP505A20 Mycosphaerella fijiensis
JGI gene model e_gw1.27.10.1
55% to CYP505A9 Nectria haematococca
See fungal pages for seq
CYP505A21 Metarhizium anisopliae var. acridum Ma102
CYP505A21 Metarhizium anisopliae var. anisopliae Ma23
CYP505A22 Grosmannia clavigera
CYP505A23 Cryphonectria parasitica
CYP505A24 Cryphonectria parasitica
CYP505A25 Trichoderma reesei
CYP505A26 Stagonospora nodorum
CYP505A27 Cochliobolus lunatus
CYP505A28 Ophiostoma novo-ulmi
CYP505A29 Macrophomina phaseolina
CYP505A30 Myceliophthora thermophila
GenPept AEO58402
CYP505B1 Fusarium verticillioides (Gibberella moniliformis, synonym)
No accession number
Jeong-Ah Seo and Robert H. Proctor
Gene name FUM6 a second fused reductase-P450 similar to CYP102
CYP505B1 Gibberella moniliformis (Fusarium verticillioides, synonym)
GenEMBL AF155773
Proctor,R.H., Seo,J.-A. and Plattner,R.D.
Characterization of four clustered and coregulated genes associated
with fumonisin biosynthesis in Fusarium verticillioides
Unpublished
100% identical to 505B1 above after 1st exon, same authors, same gene
part of a 15 gene fumonisin biosynthetic cluster
MSATALFTRRSVSTSNPELRPIPGPKPLPLLGNLFDFDFDNLTK
SLGELGKIHGPIYSITFGASTEIMVTSREIAQELCDETRFCKLPGGALDVMKAVVGDG
LFTAETSNPKWAIAHRIITPLFGAMRIRGMFDDMKDICEQMCLRWARFGPDEPLNVCD
NMTKLTLDTIALCTIDYRFNSFYRENGAAHPFAEAVVDVMTESFDQSNLPDFVNNYVR
FRAMAKFKRQAAELRRQTEELIAARRQNPVDRDDLLNAMLSAKDPKTGEGLSPESIVD
NLLTFLIAGHETTSSLLSFCFYYLLENPHVLRRVQQEVDTVVGSDTITVDHLSSMPYL
EAVLRETLRLRDPGPGFYVKPLKDEVVAGKYAVNKDQPLFIVFDSVHRDQSTYGADAD
EFRPERMLKDGFDKLPPCAWKPFGNGVRACVGRPFAMQQAILAVAMVLHKFDLVKDES
YTLKYHVTMTVRPVGFTMKVRLRQGQRATDLAMGLHRGHSQEASAAASPSRASLKRLS
SDVNGDDTDHKSQIAVLYASNSGSCEALAYRLAAEATERGFGIRAVDVVNNAIDRIPV
GSPVILITASYNGEPADDAQEFVPWLKSLESGRLNGVKFAVFGNGHRDWANTLFAVPR
LIDSELARCGAERVSLMGVSDTCDSSDPFSDFERWIDEKLFPELETPHGPGGVKNGDR
AVPRQELQVSLGQPPRITMRKGYVRAIVTEARSLSSPGVPEKRHLELLLPKDFNYKAG
DHVYILPRNSPRDVVRALSYFGLGEDTLITIRNTARKLSLGLPLDTPITATDLLGAYV
ELGRTASLKNLWTLVDAAGHGSRAALLSLTEPERFRAEVQDRHVSILDLLERFPDIDL
SLSCFLPMLAQIRPRAYSFSSAPDWKPGHATLTYTVVDFATPATQGINGSSKSKAVGD
GTAVVQRQGLASSYLSSLGPGTSLYVSLHRASPYFCLQKSTSLPVIMVGAGTGLAPFR
AFLQERRMAAEGAKQRFGPALLFFGCRGPRLDSLYSVELEAYETIGLVQVRRAYSRDP
SAQDAQGCKYVTDRLGKCRDEVARLWMDGAQVLVCGGKKMANDVLEVLGPMLLEIDQK
RGETTAKTVVEWRARLDKSRYVEEVYV
CYP505B2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_1000650|Aspni1
62% to CYP505B1
See fungal pages for seq
CYP505C1 Magnaporthe grisea
MG07953.4 42% to 505A1
AACU01000977 cont2.1474
See fungal pages for seq
CYP505C2 Fusarium graminearum
FG07596.1 AACM01000315 FGcontig1.315_scaffold4
See fungal pages for seq
CYP505C3 Aspergillus oryzae
GenEMBL BAE63564.1
54% to 505C2, 50% to 505A8, 45% to 505A3, 47% to 505B1
MRQNDNEKQICPIPGPQGLPFLGNILDIDLDNGTMSTLKIAKTYYPIFKFTFAGETSIVINSVALLSELC
DETRFHKHVSFGLELLRSGTHDGLFTAYDHEKNWELAHRLLVPAFGPLRIREMFPQMHDIAQQLCLKWQR
YGPRRPLNLVDDFTRTTLDTIALCAMGYRFNSFYSEGDFHPFIKSMVRFLKEAETQATLPSFISNLRVRA
KRRTQLDIDLMRTVCREIVTERRQTNLDHKNDLLDTMLTSRDSLSGDALSDESIIDNILTFLVAGHETTS
GLLSFAVYYLLTTPDAMAKAAHEVDDVVGDQELTIEHLSMLKYLNAILRETLRLMPTAPGFSVTPYKPEI
IGGKYEVKPGDSLDVFLAAVHRDPAVYGSDADEFRPERMSDEHFQKLPANSWKPFGNGKRSCIGRAFAWQ
EALMILALILQSFSLNLVDRGYTLKLKESLTIKPDNLWAYATPRPGRNVLHTRLALQTNSTHPEGLMSLK
HETVESQPATILYGSNSGTCEALAHRLAIEMSSKGRFVCKVQPMDAIEHRRLPRGQPVIIITGSYDGRPP
ENARHFVKWLQSLKGNDLEGIQYAVFGCGLPGHHDWSTTFYKIPTLIDTIMAEHGGARLAPRGSADTAED
DPFAELESWSERSVWPGLEAAFDLVRHNSSDGTGKSTRITIRSPYTLRAAHETAVVHQVRVLTSAETTKK
VHVELALPDTINYRPGDHLAILPLNSRQSVQRVLSLFQIGSDTILYMTSSSATSLPTDTPISAHDLLSGY
VELNQVATPTSLRSLAAKATDEKTAEYLEALATDRYTTEVRGNHLSLLDILESYSVPSIEIQHYIQMLPL
LRPRQYTISSSPRLNRGQASLTVSVMERADVGGPRNCAGVASNYLASCTPGSILRVSLRQANPDFRLPDE
SCSHPIIMVAAGSGIAPFRAFVQERSVRQKEGIILPPAFLFFGCRRADLDDLYREELDAFEEQGVVTLFR
AFSRAQSESHGCKYVQDLLWMERVRVKTLWGQDAKVFVCGSVRMNEGVKAIISKIVSPTPTEELARRYIA
ETFI
CYP505C3 Aspergillus flavus
99% to CYP505C3 Aspergillus oryzae
See fungal pages for seq
CYP505C4 Aspergillus flavus
46% to CYP505C3
Note: this seq has no ortholog in A. oryzae
See fungal pages for seq
CYP505D1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model ug.73.17.1
MTHEIPCPPAWPFLGHMTSIDPEYPTLSLHLFTKQYGEIYRLRLPGRDLVVVNSQELVHE
VSDDKRFKKSPKGGLQELRPLIGDSLLTADYPREENWGIAHRVISPSFNPIGLRGFFDDM
VDVISQLVLKWERFGPHYKIDIAEDFTAATFEVIALCCASYRMNTFYTGGTHPVATAVVD
YGVEGFARGKRGRLLSWLMRSATAKFEQDKETLLQYADELLEERKAHPTDRKDVLWAMMN
RADPVTGKKMTDLSVKQNLLTLLTAGHETTSAFMSIIIYYLIKYPEAMRKLREEIDTVLG
DRQMTADDLARLPYLLAVMRETLRLTPVAPGRVIEAIEATTLKGGQYAIDKGQDILVAVH
SSHRDPKVWGDDVDDFRPERMLDGKFEALPPDSWQPFSAGLRACIGRAIAWQEAQIMITF
LVQHFTFTLADPQYELRIKQAFTLRVHDLYVHARRRTDRRGCVTLLPPAPAPGVGLAEAK
GAPHDGGEGALPMHVFYGSNMGTCEAFAQRIVADAGRHGFKASLAALDAAVANLPTDGPV
VIVTASYEGQPPDNAAHFVEWATNMRGSGAPALAGVVYALFGCGNRDWVQTYQRVPTLVD
GALAAAGAERLLPRAEGDAGSGGFFEAFARWEGALWAALETRYATMKSGSAEGAVDVEVL
DAGVSRADVLRQPDTMMGTVLENRVLTAQGAPVKRHIEFKLPEQVTYKAGDYLTVLPMNP
PRDVRRAMARFGLLPDQEVTIRTKTPSSLPTGRPISVYTLLSAYVELSQPATTRDLRFLS
EAAKSEAEKLVFKELAENYTECVLTGRLSVLDILEAHPNVDVPFGAFLQLLPSMRARQYS
ISSSPLCDPTRASLTIRVFEAPTSPGRKDPLLGVASTYLGGLHPGDRVQLAVRPCKTAFR
LPADPAVPLVLVCAGAGLAPMRGFLQERALQKEGGRDVGKSLLFFGCRHPEEDYLYRDED
LKKWVELGIVDVRVAFSRAQDQSLGCKHVQDRLWHDRTDVMDACDKGAKLYLCGSAKMAA
GVKDKLVLVVQDAMQLEHAAAVEQFNTMMAGRFATDVFE
CYP505D2 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.73.4.1
MTEPIPTPPSVPFLGHIPLLDREVPMLSLALLAEQYGDIYRLIFPGRSSIAIASQELVHE
VSDDKRFRKTVQGPLGEVRAVAGDGLFTADVPGEENWDIAHRILMPAFSFMKIRDMFDDM
VDVVAQMVVKWERFGPRFRIDPAVDFTALTLEAISLTTMSYRMNAFYTFVQNGIHPFAKA
MNEFLQESGGRSRRGRVLSAFMRGATAKWEQNRDLMMKYVDDNARSSARKDVLDLMMNEK
DPVTGRKMTELSIKQNLLTFLIAGHETTSGMLTFTIYYLLKYPAVMRKLREEIDTMIGDR
PMTVDDVNKMPYLTAVMRESLRLGPSVPGRMIESLKDQTLKNGKYAVAKGEILVVCNFIA
QRDSKVFGDDADEFKPERMMDGKFEALPPDAWQPFGAGVRGCIGRAFAWQEVQIVLVYLL
QHFNLAFADPNYDLRLKQTLTLKPNEFYIHAIPRAERRRAIPLLGPRAGPTSAPVNGTNG
IADEGGHPMYVYYGSNMGTCEAFAQRIAGDAGRYGFSAAVASLDSATENLPTDGPAVVIT
ASYEGQPPDNAAHFVEWLGALGDADSPLAGVAYAVFGCGNHDWVQTYQRVPTRVDEGLAA
AGAERLLPRGEGDAGAGDFFEAFTRWEAALWEALGKKYETAKGSGKEAGVQIKVTNATVS
RADALRQADTMMGTVIENRVLTAPGAPEKRHLDIRLPEGTTYNAGDYLAILPTNPSRDVR
RALARFGLLPDQEITIESASPTSLPTGRPISAHTLLSGYVELAQPATTRDLRLLSEAATS
DAEKLVFQKLADNYAEEVLAARLSVLDILEAHPDVNIPLGAFLQLLPTMRVRQYSISSSP
LADPTQASLTIRVFEAPCTAGRKAPLLGVASTYLGGLHAGDRVALAVRPCKTAFRLPADP
ALPLVMVCAGAGLAPMRGFLQERAAQKRAGRDVAKSLLFFGCRDPAEDYLYRDGDLAEWT
ALGIVDVRAAFSRARDQSLGCKYVQDRLWHDRADVMAAWDKGAKLYLCGSAKMAAGVKDK
LVLVVQDAMQLEHAAAVEKFNMMMAGRFATDVFE
CYP505D3 Phanerochaete chrysosporium (white rot fungus)
JGI geme model ug.73.15.1
MSQPIPMPPSVPFLGHVTTIDAELPVMSFRLLAKQYGEIYELNMLGRCILWMLVINTQEL
LHEVSDEKRFRKIVSGGLNEVRNAAGDGLFTAHADKEQNWAIAHRILMPSFSAMNMRNMF
DDMVDVVSQLVLKWERFGPYHKINPADDFTALTLEAISFCAMSYRWVIFYSIYVRNDVHP
FARAMSDFLLESGARARRPGIIAPFMRSANAKYQQDIDVLMNFVDEIIADRRAHPTDKKD
ILNVMLHAKDKETGLGMTEDNIRRNLLTFLIAGHETTSGMLTFIMYYLLKHPEAMRKLRE
EVDTVIGERPMTVDDVNKLPYLIAVMREALRLGPPASARGASPYEDTTIGGGRFAVPKDT
FIMCSLYNIHRDTKVWGEDAEEFRPERMLDGKFEAMPPDSWQPFGYGMRGCIGRPFAWQE
AQIALVYLMQRFTFAMADPGYDLRLKQTLTIKPHEFFIHAIPRADRAHGAPLFSTPSPLR
PRAASSAQPPADTAGRTPVYVLYGSNTGTSEGFAQRIASAAAGKGMYSRSTIGTLDSAAA
HLPTDGPVVIVTASYEGQPADNAAHFVEWLSSLQGTELEGVRHAVFGCGNRDWQATYQRV
PTLVDDALTARGSIPLVLRGAGDAAASDFFEAFEKWETGLWGALREAYGVATGANAESGI
SIETLDTGKGRASILRQPDAALGTVVENRVLTAPGAPEKRHIEFKLPEGMTYQTGDYLAI
LPVNPQRDVHRALARFGLLPDQEITIRSAGPTTLPTDRPVNVSTLLSGYVELGQPATTRD
LRLLSEHAKSDSTKAALQALLDNYASDVLGARLSVLDILEAHADIALPFAAFLDTLPSMR
VRQYSISSSPLADAAHASLTISVLAAPARSGRPERFLGVASTFLGGLRAGDRVPLAVRPS
AAAFHPPADPSVPLLLVGAGAGLAPLRGFLQERALQKKAGRDVAKSILFFGCRRPDEDLL
YGDAELKEWQELGVVDVRPAFSRAPEHSFGCKYVQDRVWHDRAEAVATFKAGAKLYICGS
SRMAAGVKEQIVLIVQEDSKLEYPEAVEKFEKIMVGRFATDVFE
CYP505D4 Phanerochaete chrysosporium (white rot fungus)
JGI geme models ug.73.16.1 and pc.73.11.1
MTHPIPTPPTVPLLGHATLIDHDFPMGTNALWAREYGEIFRMCFPGRTVYVVSSYELVHE
ASNDKLFRKSVGGPLAELRSSVGDGLVTANVPGEENWGIAHRVLMPCFSTISLRNMFDDM
VDVVSQLVLKWERFGPHYRIDPAEDFTALTFEAISLCSMSYRMNPFYNSAMHPFAAAVVD
FQVECMARSRRGKLLNALIRSAKTKFEQDRDLLMQYADETVLEDRKAHPIEKKDVLWTMI
NRADPVTGKKMTDLSVKQNLLTLLMAGHETTSGMLTFAMYHLLKNPEAMRKLREEVDTII
GDRAMTADDLSRLPYLVAVMRETLRLSPSAPARIVQAMEATTLGGGKYAIAKDDTLLIAT
YVSQRDPAIWGPDAEEFRPERMLDGKFEALPPDAWQPFGAGIRSCIGRPFAWQEVQIVLV
SLMQRFTFAFADGHYDLRMKQTLTMKPHDFYIHAIPRTDRARVPPLLGVRAAPAQSTDGE
KGKVEAGEGAPPMYVYFGSNMGTAESFAQRIAGDAGRHGFKATVAPLDAAVEKLASDGPV
VVITASYEGKPPDNAGHFVEWLSNLGDESALAGVSFAVFGCGNRDWARTFQRIPTLVDDA
LGAHGGARIIPRGVGDASTGSFFESFANWEEGLWAALAEKYETAKPTSVGGLELVVTDAG
PGRADALRQPDTTMGTVVENRVLTAPGAPVKRHIEIQLPEGTSYTAGDYLAVLPTNPPRD
VRRVLKRFALLADQEITIQSADPTSLPTGRPVNVYALLSGYVELAQPATTRDLRLLIEAS
STDAEKQVFKELADNHAERVLKPRLSVLDIVEAHPSVHVPFAAFLQLLPAMRVRQYSISS
SPLVDPARATLTIRVFELPGAPARRPHLGVGSTFLARLAPGDRVQLAVRPCKPAFRLPAD
PTVPLVLCCAGAGLAPMRGFLQERAMQKQAGRDVGKSLLFFGCRDPQEDYLYKDDDLKAW
VDLGIVDVRVAFSRAPDQSLGCKYVQDRIWHDRADVLAAWNQGAKLYLCGSAKMATGVKD
KLVHVVRDATGVDEASASDKFNEMMDRFRYRYFRVRYEHVVSAAFTYCIWNYLRDHSTRF
NCPIAMACTFRLGAIARGSICATWLRWREE
CYP505D5 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.73.14.1
MTTPIPSPPSIPFLGHVTIIDREVAIYSYNLLAKQYGEIYQLNMMGALRIIVICSQELLH
EVSDEKRFRKIPRSALEQVRNAVGDGLFTANGDDPNWHLAHRILMPAFSTMNTRNMFDDM
VDVVNQLVQKWERFGPRHKIDPAQDFTALTFEAITFCAMSYRELTLPQEGVHPFARAMAD
FLVESGNRALRPGIVQPFMRSTNSKYEEDIKIMEHYVNDIYEQRKANPTDKKDILNLMMY
GKDTQTGEGLSEKTIKDNLLTFLIAGHETTSGMLTFIIYYLLKNPEAMRKLREEVDTIIG
SRPMTVDDVHKLPYLIAVMREALRLGPPAPMRGAASFEDTLLKGKYPVAKDVPIYCGVYM
VHRDPKVWGEDAEEFRPERMLDGRFEALPPEAWQPFGFGVRACIGRPFAWQEAQITVVYL
MQRFTFVMHDPSYDLQLKQTLTIKPHEFFIHAIPRTDRPSIVPIPTPSSTLLRDQTAPAA
QPPVTTPGEGGGHRMYVLYGSNTGTCEAFAQRVASDATVHGEVSVFIGTLDSAAGHLPSD
GPVVVVTASFEGQPADNAAHFVSWLTALNGSALADVSFAVFGCGNRDWASTYQRIPTLCD
DTMAARGGKRLVPRGEGDAGSSDLFESFEHWEAGLWEALQKTYGTTKVEGRQEAIKVSTV
DAGTARATALRQPDTMLGTVVENRLLTSPGVAEKHHIEFQLPDGLTYRTGDYLAILPMNP
SRDVQRVLAHFSLLPDQEVTISAAGPSPLPTGRPVNVSSLLSGYVELSQAATTRDLRILM
SAAKSEDTKAALSELLDGYAEKMQAARLSVLDILEAHPGLDISFALFLQLLPSMRVRQYS
ISSSPLADPTRASLTVSVLSAAPTAGRREPFLGVASTYLASLRAGDCVQLAVRPSAAAFH
PPADPAVPLVLFCAGAGLAPMRGFLQERALQKQAGRDVAKSILFFGCRSPQHDFLYADSD
LRTWTELGVVDVRPAFSRDTEHSAGCKYVQDRVWADREDVVKVWKAGAKMYVCGSGRMAT
AVKQKLVEIIAAQLNVDSEKATETFNNIIKGRFATDVFE
CYP505D6 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.17.40.1
MTSTIPTPPSIPFLGHVASIEREVPLRSFRLLSEQYGEIYELNILGRKLLVVSSAKLMSD
VSDDKKFYKNMSGPLMQVRNAVGDGLFTAYGEEPNWGIAHRLLMPAFGTASIRDMFPDML
DLASQLVLKWERFGPKHRIDPAEDFTRLTLDTIALCAMSYRLNSFYRDSSHPFVQSMVDF
LVECNLRANRPGLLTSVMVQTNAKYEEDIKTMTELADEIIAERRRNPTDKKDLLNIMLYS
KDPKTGQSLSDVNIRNNLLTFLIAGHETTSGLLTFALYYLIKNPEAMRKAHEEVDEVLGD
QQIQLTDIGKLKYIDAVLRETMRLSPTAPMRTVRPFEDITIGDGKYFVPKDYTVVINTIV
AQRDPTVWGEDSNEFHPERMLDGKFEALPPNAWQPFGFGMRACIGRPFAWQEAIIALAVL
LQKFDFVLDDPSYELELKQSLTIKPAHFYVHALPREGKPQLLATPSAAPFSSHARETTNA
SLPASPGTEAKQPMYVLYGSNTGTSESFAQRIANGAAAHGFRATLGTLDSVADHLPTDGP
IVIVCASFEGEPADNAAHFVERLTSLQDKPLQNLRFAVFGCGHHDWFRTYQRIPKLIDQT
LEDRGAQRLVPRGEGDAGSSEFFEAFEAWETKLWEVLPEEYNTVVKQDITSGLKVETVGE
GATRAVDLRQHDAALGTVIENRVLTAPGAPQKRHIEFELPEGVTSRAGDYLAILPSNPPQ
DVHRVLARFGMLPEQQIVISSSGPSSLPTGRQISAFDLLSGYVELSQPATARDVRTLLNI
DSSDATKESLKALLESYSDAVLGRRLSVLDLLEQYPDIKLPFAAYLALLPSMRIRQYSIS
SSPLWNAQRVTLTVSVLEAPALSGRKEPFLGVASTYLANLRPGDKVQMAVRASNAAFHLP
QDPRTPLVLFAAGSGLAPMRGFLQERALQKKAGREVGRAVLFFGCRRPDEDYLYSDSDLK
EWEELGVVELRPAFSRAPEKSEGCKYVQDRVWHDRRALDGLYEAGAKWFVCGSGKVARGV
KEVLTAMIKESRGYSDEEAAAAFERATVGRFATDIFE
CYP505D7 Phanerochaete chrysosporium (white rot fungus)
JGI geme model gx.187.5.1
Partial, needs more work
ATPIPSPPSVPFLGHVTIIDREVAIYSYNLLAKQYGEIYQLNMMGAKVVVICSQELLHEV
SDEKRFRKVPSSALDQVGNAAGEGLFTAHGDNPNWHLAHRILMPAFSTMNTRNMFDDMVD
VVNQLVQKWERFGPRYKIDPSQDFTALTLEAITFCAMSYRYGRIXVHPFARAMADFLVES
GNRALRPGIVQPLMRATNSKYEENIKIMQKYVDDVYNQRKENPTDKKDILNLMMYGKDPK
TGERLSEKTIKENLLTFLIAGHETTSGMLTFILYYLLKNPEAMRKLREEVDTMIGSRTMT
VDDVHKLPYLIAVMRETLRLGPPAPARGTAPFEDTLLKGKYPVAKDGRIYCGIYMVHRDP
KVWGEDAEEFRPERMLDGRFEALPPEAWQPFGFGVRACIGRPFAWQEAQITVVYLMQRFT
FVMHDPSYDLQLKQTLTIKPHEFFIHAIPRTDRPSIVPIPTPSSTLLRDQTAPTAQPGPV
TTPGEGGGHRMYVLYGSNTGTCEAFAQRVASDATVHGFKAVIGTLDSAAGHLPSDGPVVV
VTASFEGQPADNAAHFVSWLTALNGSALADVSFAVFGCGNRDWASTYQRIPTLCDDTMAA
RGGKRLVHRGEGDAGSSDLFESFE
CYP505D8v1 Postia placenta (brown rot basidiomycete fungi)
CYP505D8v2 Postia placenta (brown rot basidiomycete fungi)
CYP505D9 Postia placenta (brown rot basidiomycete fungi)
CYP505D10 confidential basidiomycete
CYP505D11 confidential basidiomycete
CYP505D12 confidential basidiomycete
CYP505D13 confidential basidiomycete
CYP505E1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_3000014|Aspni1
77% to CYP505E2, 48% to CYP505C3
See fungal pages for sequence
CYP505E2 Neosartorya fischeri
~77% to CYP505E1
Note: this seq does not have an ortholog in A. fumigatus
one stop codon
See fungal pages for sequence
CYP505E3 Aspergillus terreus NIH2624
AAJN01000001.1
79% to CYP505E2
See fungal pages for sequence
CYP505F1 Mycosphaerella graminicola
JGI model estExt_fgenesh1_pm.C_chr_30459 [Mycgr3:99701]
JGI model Mycgr3/chr_3:2874198-2877434
47% to CYP505A1 AB030037 Fusarium oxysporum
49% to CYP505A2 N. crassa, 52% to 505A13 Aspergillus fumigatus
52% to CYP505G1 in this genome
See fungal pages for sequence
CYP505G1 Mycosphaerella graminicola
JGI gene model estExt_fgenesh1_pm.C_chr_70227 [Mycgr3:100796]
JGI gene model Mycgr3/chr_7:1478709-1482337
52% to CYP505F1 in this genome, 46% to 505A1 Fusarium oxysporum
See fungal pages for sequence
CYP505G2P Fusarium verticillioides
53% to CYP505G1, pseudogene,
possible orthoog of CYP505G1 Fusarium oxysporum
See fungal pages for sequence
CYP505H1 Fusarium oxysporum
46% to CYP505B2
See fungal pages for sequence
CYP505H1 Fusarium verticillioides
94% to CYP505H1 Fusarium oxysporum = ortholog
See fungal pages for sequence
CYP505J1 Aspergillus clavatus
46% to CYP505A15
See fungal pages for sequence
CYP505K1 Mycosphaerella fijiensis
JGI gene model e_gw1.1.1150.1
48% to CYP505A2 N. crassa
See fungal pages for sequence
CYP505L1 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_180062
46% to CYP505A2 N. crassa
46% to CYP505K1 Mycosphaerella fijiensis
See fungal pages for sequence
CYP505M1 Metarhizium anisopliae var. anisopliae Ma23
CYP506A1 Fusarium oxysporum
GenEMBL X82490
Mouyna,I. and Brygoo,Y.
Disruption of a Fusarium oxysporum f.sp. elaeidis cytochrome P450
gene by a repetitive sequence.
Unpublished
CYP506A1 Fusarium oxysporum
93% to CYP506A1P rev Gibberella moniliformis
See fungal pages for sequence
CYP506A1P Gibberella moniliformis 7600
GenEMBL AAIM01003201.1
Note this seq has only 1 aa diff to 506A2 at 10017,
but then a large gap
Like a pseudogene
77% to 506A2
formerly CYP506A3P
also = Fusarium verticillioides FVEG_09850
10017 DMQIEYTHFGGPAEYVIHAIKANLTGSL (1)
FHDKVLR
10311 LIATNNARVFQGTTASLDEEWLAASTGYVLACFDCIRALKQWHPYLRPLVYRFIPERAAI 10490
10491 KDQWAKGRKRVMASMRERQEKGGNLEDPPTMLDHLSNGRNEHIRDDVELQLLHQMTLI 10664
10665 AVGTVTTFSSTTQAIYDLVAHPEYIPILREEVESVPRDENGNFTKESTVAMDKLDSFLKE 10844
10845 SQRFNSPDL (1)
TTFQRAAIADMTLPDGTFVPKGTKLEINTCSIHK 11024
11025 DHELYENPEEFNGLRFHEWRKEPGKEKKYMYSSSGTDDLSWGFGRHACPGRYLSAINI 11198
11199 KLIMAELLINYDIKLPDGVSRPENIEFEVLV 11291
SLNEMVLGSVADVGSAPLNRISRSFSRIGIIRWNGVCLVR*
CYP506A2 Fusarium graminearum
AACM01000093 Gibberella zeae
See fungal pages for sequence
CYP506-un1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.28.129.1
Necha1/scaffold_28:447825-448775
pseudogene probably from a CYP506 sequence, subfamily not assigned
35% to 506A2 mid to heme, 38% to CYP506A3P Gibberella moniliformis
the top part of this seq seems to be missing
See fungal pages for sequence
CYP507A1 Neurospora crassa
GenEMBL AA902084, AA902085, AA902086
Nelson, M. A., Kang, S., Braun, E. L., Crawford, M. E., Dolan, P. L.,
Leonard,
P. M., Mitchell, J., Armijo, A. M., Bean, L., Blueyes, E., Cushing,
T., Errett, A.,
Fleharty, M., Gorman, M., Judson, K., Miller, R., Ortega, J.,
Pavlova, I., Perea, J., Todisco, S., Trujillo, R., Valentine, J.,
Wells, A., Werner-
Washburne, M., Yazzie, S., and Natvig, D. O.
Expressed sequences from conidial, mycelial and sexual stages of
Neurospora crassa.
Fungal Genetics and Biology 21, 348-363 (1997).
Neurospora genome project
Sequence data
most like CYP57A1 (36% over 129 amino acids)
NM1B1-T7, NC4D11-T7 and NM1D12-T7
SPLHPRISAQVRDFHRHPHRLISSSSIITDQEARKLPYLQAVLYEAIRMM
PPLMNGFPRQVPAGGDTICGRFVPGGTDIFVNYVGMLRDKSVFGEDANVF
RPERYLEGDEERRNRMWKTTDLAFSHGRWRCLGQRLAWVQLQKVVVEFMR
NFEMQIVDPMHPCRLRCYCTPEMDDLMVKVTEAKWD*
CYP507A1 Neurospora crassa
No accession number
Neurospora crassa sequence contig 1.80 (supercontig 10)
MALTELLGALPLVSSGMSKLQVAAIYLAISFVSWYIISSFTDWYRLKAFPGPPTTGFSNLWAARAI
WTGKAHKIFPATQEKYGPITRIGPNALMVCDAATVVHINGVRGGYARSQDFYDCIRMDPW
DHTVLSESDSAMHNERKTKVYAGYHGKGEMDMEKDVDMVIAEAVELVRKKYMNSAATSGS
KPPLDYTRIARYIAVDSVTQTGFGKAWGDVREEKDHFGWLGFADMIVGYLHSLAYVPA
ISKIVISTPLMVLLGPKPTDKSGIGAFLG (2)
HAPQSRHRPLKHACKSSLQLFSHHPISLSINTCQDEWVKNGISQRTAVLEVSAQLPAGSDTTASAL
QGTMLYLLSTPSAYIRLKSEISTAIRTGLISSSSIITDQEARKLPYLQAVLYEAIRMMPPLMNGF
PRQVPAGGDTICGRFVPGGTDIFVNYVGMLRDKSVFGEDANVFRPERYLEGDEERRNRMWKTTDLA
FSHGRWRCLGQRLAWVQLQKVV (0)
FMRNFEMQIVDPMHPCRLRCYCTPEMDDLMVKVTEAKWD*
CYP507A1 Neurospora discreta
JGI gene model estExt_fgenesh2_pg.C_170074
89% to CYP507A1 N. crassa
See fungal pages for seq
CYP508A1 Dictyostelium discoideum (cellular slime mold)
GenEMBL 16 ESTs C92049, C89925, C90052, C91122, C25600
C94043, C94448, AU034703, AU033852, AU037735, AU034252
AU037979, C92378, C24684 and clones SSC755, SLJ668 from
The Tsukuba dictyostelium genome project.
31% identical to fish 1A sequences and CYP73 sequences
MALFEIIISLF
VVYIIHNAISKYKKIHVNELCGPTPIPILGNLHQFGELPHRVLTKMTKKYGHILRVYMAD
MYTVVVSDPLLIREMYVDNSDIFTDRVKKPSVEHGTFYHGTVTSYGEHWKNNREIVGKAM
RKTNLKHIYELLDKQVDVLIRSMKSIETSGKTFDTRYYITKFTMSAMFKFLFNHDIPEDE
DINKGDTQKLMGPMSEVFQNAGRGSLFDVINITQPLYLLYLEMFDQSFKDIMKYHREKYN
EHLKTFDPDVERDLLDILIKEYGTDNDDKILSILATINDFFLAGVDTSSTALESMVLMLT
NYPEIQEKAFDEIKTVVNGRSKVNLSDRQSTPYLVAVIKETLRYKPMSPFGLPRSSSKDC
MIGGHFIPKNAQILINYQALGMNEEYYENPEQFDPSRFLKVESNVAFLPFSIGIRSCVGQ
SFAQDELYICISNILLNFKLKSIDGKKIDETEEYGLTLKTKNRFNVTLEKRII*
CYP508A2 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 22+45+69+86+88
CYP508A3 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 21+67+72+82+87
CYP508A4 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 66+70
CYP508B1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 15+77
CYP508B2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 60
CYP508C1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 4+23+24+83
CYP508D1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 59+81
CYP508E1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 71+85
CYP509A1 Cunninghamella elegans (a fungus)
GenEMBL AF249299
Wang,R.F., Cao,W.W., Khan,A.A. and Cerniglia,C.E.
Cloning, sequencing, and expression in Escherichia coli of a
cytochrome P450 gene from Cunninghamella elegans
FEMS Microbiol. Lett. 188 (1), 55-61 (2000)
Submitted to nomenclature committee Feb. 29, 2000
CYP509B1 Rhizopus oryzae RA 99-880 (Zygomycete fungus, Mucoromycotina)
GenEMBL AACW02000089.1
43% to CYP509A1
MIFEVIQEIIQPWIESNVRILIVFGIVLAFYALVQRYNRPPAALAHLPYVSFFSFLK
YGFKDEVYDTYAKEKLLPLLKAKG (1)
291331 GWVVRLADPVAIKQFTLKQGK (2)
GLFASPTIQGWVSIHLNSNHEIPSIEHT (instead of the third exon above)
(?)FPKAMSNAGEEGTLIHRF 291158
291157 IGGPNIVFLSGPDWKRHRK (0)
IANLAFQRSMPVQLFGDLAKRML 290978
290977 RSMEKTEEDAIDVNDLFRRFTLDAIGNGGF (1)
GFDFHAIEDKE 290807
290806 SKWVEYYESVMQGMASPFYIVFPAFDTKYVHWFRKRKQLHDNLSKLMENMDEIIEKKRKL 290627
290626 VYENGQGESKEKDLLTLMIESEMKSEGESLSNEELR (0) 290522
290469 SNLCIFFLAGHDTTANTLAAIIYELAKNKEIQEKARKEAIRILGDGPEDTAPTAEQL 290299
290298 KELDYINMIIKE (0) 290263
290192 TLRRHPPAYVTTDRVVQNDLVLGDVHIPKGSDLCLDIYSLHHNADIWSNPFEFNPERFAPGGEADS 290019
290018 QRGIAWAPFSSGGRMCVGMNFSLTEQRVLIPML (1) 289923
289869 LKKYTWSLPNDSSHQHELQKRGIAWGLVTFKDKVKIEFKKRN* 289741
CYP509C1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
in CYP56 clan
93% to P450-33, 90% to P450-30var1, 89% to P450-31, 87% to P450-34_var1
87% to P450-29, 84% to P450-7_var1, 65% to P450-39, 59% to P450-36
56% to P450-42, 53% to P450-20a, 53% to P450-12, 40% to 509B1 =P450-15,
38% to CYP509A1
See fungal pages for seq
CYP509C2 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
93% to P450-32 in CYP56 clan
See fungal pages for seq
CYP509C3 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
87% to P450-29 in the CYP56 clan
See fungal pages for seq
CYP509C4 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
89% to P450-30var1 in the CYP56 clan
See fungal pages for seq
CYP509C5 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
87% to P450-32 in CYP56 clan
See fungal pages for seq
CYP509C6 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
in the CYP56 clan
83% to P450-7_var1
See fungal pages for seq
CYP509C7P Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
37% to CYP509B1 Rhizopus oryzae, in the CYP56 clan
P450-7_var1 has a stop codon in the I-helix
86% to P450-33, 85% to P450-32, 84% to P450-30var1, 84% to P450-31
84% to P450-29, 83% TO P450-34_var1, 62% TO P450-39,
58% TO P450-36, 53% TO P450-20a, 55% TO P450-42, 53% TO P450-12
See fungal pages for seq
CYP509C8 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
66% to P450-33 in CYP56 clan
See fungal pages for seq
CYP509C9 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
60% to P450-33 in CYP56 clan
See fungal pages for seq
CYP509C10 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
60% to P450-36 in the CYP56 clan
See fungal pages for seq
CYP509C11 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
62% to P450-12, in the CYP56 clan 35% to 509B1
See fungal pages for seq
CYP509C12 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
52% to P450-7_var1 in the CYP56 clan, 36% to 509B1
See fungal pages for seq
CYP509C13P Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
53% to CYP509C10
45% to CYP509C9 in the CYP56 clan
AACW02000137.1 (-) strand
See fungal pages for seq
CYP509C14 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.49__3
40% to CYP509C4 Rhizopus oryzae
first amino acid is I = ATA instead of M = ATG
conserved location for M in CYP509C15 and CYP509C16
See fungal pages for seq
CYP509C15 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.3.167.1
67% to CYP509C14 Phycomyces blakesleeanus
See fungal pages for seq
CYP509C16 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.3__395 revised
67% to CYP509C14 Phycomyces blakesleeanus
See fungal pages for seq
CYP509C17 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.3.168.1
76% to CYP509C14 Phycomyces blakesleeanus
See fungal pages for seq
CYP509D1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.25__98
49% to CYP509B1 Rhizopus oryzae over the last 405 aa region
See fungal pages for seq
CYP509E1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.11.60.1
43% to CYP509D1 Phycomyces blakesleeanus
See fungal pages for seq
CYP509F1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.20.54.1
51% to CYP509D1 Phycomyces blakesleeanus
See fungal pages for seq
CYP509F2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.20.55.1
53% to CYP509F1, 53% to CYP509F3
See fungal pages for seq
CYP509F3 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.20__100
54% to CYP509F1 Phycomyces blakesleeanus
See fungal pages for seq
CYP509F4P Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.20__103
54% to CYP509F3 Phycomyces blakesleeanus
See fungal pages for seq
CYP510A1 Lentinula edodes (a basidiomycete fungi)
GenEMBL AB045779
Akiyama,R., Sato,Y., Kajiwara,S. and Shishido,K.
Cloning of novel Cytochrome P450 gene family from Basidiomycete
Lentinus edodes
Submitted to nomenclature committee July 17, 2000
CYP510A2P Lentinula edodes (a basidyomycete fungi)
GenEMBL AB015310
Partial sequence called SHP1 for small heme binding protein
This is clearly part of a P450. It appears to be
Interrupted by an insertion so it is a pseudogene
About 70% identical to 510A1
CYP510A3 Lentinula edodes (a basidiomycete fungi)
GenEMBL AB049963 (still confidential on Feb. 14 2001)
Susumu Kajiwara
Submitted to nomenclature committee Feb. 12, 2001
Clone name Le. CYP2 (499 aa)
67% to 510A2P 87 % identical to 510A1
100% identical to 510A1 from 286-483
CYP511A1 Botrytis cinerea (a plant-pathogenic fungus infecting over 200
plant species)
GenEMBL AL114463.1, AL113894.1, AL112730.1
These cDNAs overlap and cover most of the intact sequence
Bettina Tudzynski
Submitted to nomenclature committee Nov. 20, 2000
CYP511A1 Botryotinia fuckeliana strain T4
GenEMBL AY277723
Viaud,M., Brunet-Simon,A., Brygoo,Y., Pradier,J.-M. and Levis,C.
Cyclophilin A and calcineurin functions investigated by gene
inactivation, cyclosporin A inhibition and cDNA arrays approaches
in the phytopathogenic fungus Botrytis cinerea
Mol. Microbiol. 50 (5), 1451-1465 (2003)
CYP511A2P Fusarium oxysporum
44% to CYP511A1 Botrytis cinerea, N-term, cannot find whole seq
78% to CYP511A2P Fusarium verticillioides,
probable ortholog of the pseudogene
See fungal pages for seq
CYP511A2P Fusarium verticillioides
78% to CYP511A2P Fusarium oxysporum
probable ortholog to CYP511A2P Fusarium oxysporum
See fungal pages for seq
CYP511A3 Metarhizium anisopliae var. acridum Ma102
CYP511A3 Metarhizium anisopliae var. anisopliae Ma23
CYP512A1 Coriolus versicolor (a Basidiomycete fungus)
GenEMBL AB057426
Ichinose,H., Wariishi,H. and Tanaka,H.
Identification and characterization of novel cytochrome P450 genes
from the white-rot basidiomycete, Coriolus versicolor
Appl. Microbiol. Biotechnol. 58 (1), 97-105 (2002)
Submitted to nomenclature committee Feb. 14, 2001
Clone name P450Cv365
Most similar to AL355928.2|NCB1D4 Neurospora crassa unnamed P450
(35% over 364 amino acids) 16/17 identical amino acids at heme
signature region. This same region also conserved in
CYP54 from Neurospora crassa
CYP512A2 confidential basidiomycete
CYP512A3 confidential basidiomycete
CYP512A4 confidential basidiomycete
CYP512A5 confidential basidiomycete
CYP512A6 confidential basidiomycete
CYP512A7 confidential basidiomycete
CYP512A8 confidential basidiomycete
CYP512A9 confidential basidiomycete
CYP512A10P confidential basidiomycete
CYP512A11 confidential basidiomycete
CYP512A12P confidential basidiomycete
CYP512A13 confidential basidiomycete
CYP512B1 Phanerochaete chrysosporium (white rot fungus)
JGI geme models pc.30.92.1 and genewise2nd.30.46.1
MSLHQVYDAVVAHGDMGTLLVYMAYSVPLVMFLYSLFSPASLRHIPTEGGPSFPLLSYKA
ARAYLRDATGILQRGYDKHKGKPFKVAMPDRWVVVLTGKKLVDELQRLPDDAVSFIKGAS
DLSGTEHMFGRQVIDDPFHVPIIRTHLTKNLAPMFSDVFDEVSIAFQELIPACDGEWVPV
HAIKVARSVVARTSNRIFAGLPICRHPEYLNLVINFTVDVAKGRYALLLFPPALKGIAAK
ILTNIDGRIKEGLKYLGPLIEQRMALAEKFGNDSSEKPDDMLQWIIDEVRARNQSVFEVV
RTVLLVNFAAIHTSSNSFTHALYHLAANPEFIAPLREEIETIVSEEGWSKAAIGKMWKLD
SFMRESQRYNGINSVSVKRKALKPLTLSDGTFIPKGTVLVTPTVATHFDDDNYKNPTVFD
PFRYYREKEQDMSAVKHQFVTTSPDYVSFGHGKHACPGRFFAANELKAMMAYVVVNYDVK
FEKEGVRPENIYAAMGISPDPNARVLFRKRESIVSV
CYP512B2 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.93.1
MTPSHSFPDLVASCISAWTLCFALGFSIAAASFYSLFGPFNLHHIPTVGGSSIPLISHRG
ARKYMRDAKGVLQDGYKHKGKAFKVALTDRWLVVITGKRLVDELQKMPEDVASFVGAVAD
FQGLRYIFGQKVLDDPFHVNIIRSHLTKHLSSVFGDICDEIYVAFSELIPQQDEEWVPVH
AIQVVRTIVARASNRVFVGLPVCRNAGYLSLAVNFIVDVAKARDFIALFPPVLKPLAAKM
TSDIGTRVQEGMQYLEPLINERLRLMEKFGKDWTDKPNDTLQWMMDGIMERDGTIEQLVR
IVLLENFSSIHSSSNTFTHALYHLAANPEYITPLREEVETAISEEGWTKAAMSRLRKVDS
FLRESLRLNGINPVSMQRKALISFTFSDGTYIPKGTILVTPALATHHDEDNYEDATTFKP
FRFVGENPEDDVPLVTTSADFVPFGHGRQACPGRFFAAHQMKAMMAYLVLNYDVKFENEG
VRPQNVHGVLSVQPDPKARVLCRRRKSSYT
CYP512B3 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.113.1
MASNHLFSGVLPLDRAASTLGYLVCGALLALLLQNILTTISLRHIPTVGTSTLPLLSYKG
AYDFTRDIKGVFQQGYAKYKGRAFKIAFTDRWFVVLTGRKLLEELHRLPDSTTSFNHASG
SITGSTYIYGRGWLSDPWHIPIIRDRLTKHLAASFGDMYDELETAFRELMPSCEEEWVPV
HFITMARTVVARTSNRVFVGLPACRNLGYHTLLVNFALDVSKARNRLAWLPPALKRVAAR
ALTRIDSRIEEGMQYLGPTIRARIVEMERYKGDWPDKPNDILQWIMEELIARKMPMEEAV
RIILRINSSAVQTTANSLTHAIYHLAANPDLIAPLREEVDAVITDEGWTKLAMSKLSRLD
SFMRESLRLNIVNPLSVRRMALKSFTFSDGTFIPKGTLMVTPAHATHLDEANYEHASVFD
PWRFVHQKEEDLSPTKHQFITTSPEFVAWGHGKHACPGRFFASNELKAMMAYIILNYDVK
FARAGVRPDNVYSGLTVAPNQEANVLFRRRQTQ
CYP512B4 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.114.1
MAFSDVVATVGAGPWVAYMMCAVLLALLLYSLFSPASLRHIPTEGGSSLPLVSYLGAYNV
LRNLQSVLQRGYDKHKGKAFKIALPDRWVVVLTGKTLVDELQRMPEESASFIDATTELTG
FGYIWGPRMRKDPCHVPIIRNQLTRQLSSAFGDIYEEIELSFQGLMPACEKDWTPVHVIE
VARDVVARASNRVFVGLRVCRNPDYLDMLVDCAVSVASARNTLMLFPFVLKTFAAKNVVN
MDRRIRRGMQHLGPIIEERMSLLRSLGNDWPDKPDDMLQWIIDEVAARQMPKEDVVRNIM
FLNFAAIHTSSNSFTHAIYHLAANPDYLGPLREEVEAVTAKEGWSKTAMGRMWRIDSFLR
ESQRVNSINPLTVIRRTRTSLTLSDGTFIPEGTVVAAPAYPTHFDDENYVGGDTFDPWRY
VREKEQDLSPSKHQYVTLSPEYVPFGLGKRACPGRFFAANELKAMLAYLVVNYDVKFEKE
GVRPENMHVGLTISPDPAAKVLFRKRRS
CYP512B5 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.118.1
MARSDILDALSLGRTELSTTYLVFGLFLALFLYSLFSPASLRHIPTVGSSSLPLLSYKGA
YDFLRDGRSLLQRGYNQYKGKVFKVAFTDRWLAVVTGRKLVEEVQRLSDDVISFPDASGE
VTGFKYIFTKCALSRDPFHVNMIQRQLTKHMSVAFDDLHDEFETAFKELLPHNETAWVPV
HAIEVARKVVARASNRIFVGLPVCRDKAFLDLMVNFTLDVARARDLLALFPPALKPFVAK
LVVKLDSRIEEGMQVLRPIIQERMEIIEKFGKDSPEKPDDMLQWIIDALVERNEPMEQVV
LITLFVNIAAINTSSNSFTHALYHLAARPEWIAPLREEAEAVIGNEGWTKNAMGKLVKID
SFMRESQRYNSIVPLTCMRKALQPFTLSDGTHIPRGTILVTPAIATHFDDEHYADAASFD
PSRYVPVADAKQGGAPKQYVTTTAEYVPFGHGKYACPGRFFAGTELKAMMAYLVLNYDVK
FAQEGVRPPNAATTLSTRPHQEARVLFRKRNSSVQ
CYP512C1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.76.1
MSSMNAPALPATHIVAGAILVWLLVRTFGTQNLRHIPTEGGPSLPIISFLGLHAFLTRSR
EILEDGYQTHKGRAFKVALIDRWLVVLSGKKLVEELQKMPDDTVESATTEMFNMQHVFAS
NWHKDPVHSSLLRSLTRNLGVVFSDMFDELDTAFRECVPANAERWLPVQAHTTMASIVTR
AANRIFVGLPVCRDAGYIHMMIHVAEDVSDAVRTLSMLPTFMKPFVARRATVIDQRIQQC
LDYLRPAIADRMSMLERFGKDWEEKPNDVLQWIIDEVTARNQGEDEVARIVLFINFGAIE
TTSFAVTHALYDIVSRPGLADVLREEVEAAVATEGWTKAATNKMRKLDSVLRESQRLNGP
TTASMFRRVLQPVTLSDGTYLPAGTTVVTPTLATHFDDTNYADAQTFDPLRFYKPDGVQA
QLVTTSADFVTFGHGKHACPGRFFAANELKAMMAYILMHYDIRPEREGVRPENVYRGLNV
LPDANARVFFRRRQTD
CYP512C2 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.77.1
MVLTTDFGGISTTHVVIGAFVTWLLLRYFSAKNLRHIPTVGGPSVPILSIVALYNFLANG
KKVVLDGYQKYKGKAFKVALLDRWLVVLCNPKLVEELQKLPEALVGYSLLEAXGTIFETK
HIFGADLLTDPVHLVLLRTLTRNLGQVFGDMYQEVETSFQELVPANEKEWLPVHASPIMR
TIVTRAANRVFVGVPVCRDEGYLHLMVHFAEDVNKAFGLYTVVPSFAQGFVARKAKAVMD
DCIERCLGYTRPTIKDRTTMMDSFGDNWADKPNDMIQWTIEETKARGQGEYDMARMLMFI
NSGAVETTSQAVIHALYDISVRPELADELREEVERAIAEDGWTKDATNKMRKLDSFLRES
QRINGPMIVSMFRLVREPVTLSDGTFLPAGTTIASPTLGAHFDDSIYPNASTFDPLRFYK
AEAAGQPQFVTTSPEYLTFGHGKHACPGRFFAVNELKAILAYMLMHYDIKPEQDGVRPEN
KSMGLGVLPNPDAKVMFRKRHAG
CYP512C3P Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.30.36.1
60% TO 512C1 PSEUDOGENE
NDLLQWIMDEAVARDKS (FRAMESHIFT)
QEEIARMVLFLN (FRAMESHIFT)
FGAIQTTSCV (1)
LSMFPNILTPVTLSDGTFLPAGTTVVTPVLATHYNEDNYTNAALFDPFSCKDNRSGGQQF
VRTSADCVTLGHGRML (1)
CPGRFFAAAELKTLVAYVLVNYDLRPETEGVRPVNIYKGLT
V*PSETAKVLFKKRQTDE*
CYP512D1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.27.9.1
MQSSVGEVFASAPTLAKLLAGAAFVLFLNSLWNIWKLRHIPTVGGPAIPILCYIGTFRYL
QDPQKILQEGYEKYKAKPGMFKIAAPDRWLVVVGHPNLIDELQKHSDEQVSFMDAATEFV
GTRYALPGTIADDPWHIPPLKQHLTHAIGSFFGDMLEELRVSIEERIPSNEKDDEWVAIP
ALDTFFWVFTRVIDRIIVGLPIRDTEFIKLMVEFTMSIGIARFFIGLVPPMLKPAMAKLA
ARGVHKATAEAEKMLAPVIADRVRHLDEFGEKWADKPNDLLQINIEEARAQGRPLDEIVI
RTIVSIFVGVSTSAASFVHVLYHLAADPELQAALRTEVEGAIARDGWTKAALVGMHRVDS
VLRESQRVNGINSVSVMRTALQDITLTSAGAPVCLPAGTLCVAPERALHADKEHYPDPDA
FVPFRFAELRATADARGGAQHQFVSTSTRYVPFGHGKHACPGRFFAGNEMKAAVAHLVSN
YDVRLPDGASTRPPNELFGLAIVPNRSAKVMSRRRQPVV
CYP512E1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.154.15.1
MSDYSSLLAYIFISLATLAYLKRLLWPDRQQLEHIPAIGPTAPILSYWGAFRWLSHGTEI
TQKGYAKYKGRPFKVANFNRWLVVVSGPKLIDDIRKAAEHELSFEEAAHENLEVRYTAGP
CIAENSYHVPIVRGQLTRNLPFLFNDVRDEVAKAFGDHIPPTDDWTPVAAHPVIMQIVAR
ATNRVFVGAPKCRDPDWLDLSIQFTADLILGAHIITQFPQFLKPLAARFFTRVPAAIRRG
RRHLERTIEHRKACLEQYGADWPDKPNDLISWLLDEAKGEERTIHNLVTRVLTLEFAAIH
TTSNSFVHALYQLAAHPEWAEPLRDEIEQVVKREGWSKSSLDKMHRLDSFLKESQRYYAL
GGVTMDRRAMKDFTFSDGTVIPEGTFVGVAVLATQHDPQYYDDPDTFNPWRFSDLREESD
ESGRHLLVSTGIEYFPFGHGRHACPGRFFAAIELKLMLAHIVMNYDVKAELDGVVPPILE
FGQNLAPNMKAKVLFKNRQRS
CYP512F1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.15.28.1
MISIDSISLISGLISFAFIAYYLRQDKLQHIPSPGPTGPISSWYAAYKYIRGDAPQIIEE
GYRKYKGRIFRIADLNRWTVVVTSPSLVEELRKAPEDVLSFHEGIRYSLQLDYTFGREAV
EHEYHIPVIRTQLTRHLTPLFADIHDEIVQSFTDLVPPSDTWTSVRVVPTVMQVVSRTSN
RVFVGLPYCRDPAFCALAVRFATDVVKTGVALHLTPRALKPLGVRLVSPVSKRVEEGKGD
HRQAGGRPAPRQPGGRPARAAQGACGNWPDKPEDMIQWLIEEANEDERTVEGLVLRILIV
NFAAIHTSSMSFTHAVNMLAAHPECIAPLREEIEEVVREEGWTKAAVQRMRKLDSFMKEC
QRLHGLGAVTMSRVALQDYTFSDGTRIPRGTLVMAASRPIHHDAALYVPDADAFDPWRFA
RLRAADADASIKHQMVHTSAEYLAFGHGKHACPGRFFAVNELKLMMAHVLHTYDIRPQTS
VPPGRWIRHSLLANPIATVDLKKRQT
CYP512G1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.16.37.1
SVPTMGPTAPLLSYWGVLRYMTRPRDVLREGHVKFGGRPFRVASPLRWQYIVSSPELIDE
LRRAPDAELDPLAAADDILHFVKALGTKFASNTYHVPIVRTTLTKNIGTLLPSVLDEMRV
AFARYIPADKEWHPVVAHDTNVRIVTQTSSRIFVGLPLCRDPELLKITMSYTPTVMKTGL
LLKVLPRPLQSFVQRGSGSIDALIDRAHRLLLPTIEERRRMMDKYGAEWLDKPNDMLQWL
MDSAEGEERTPRGLAARMLAVYFAATDTAALGFTVALYRLATHPEYVQPLREEVEAVIAQ
DGWTREAFRKMPKVDSFLKECMRLQGPSTLLLQRKAMQDFTFSDGTFVPKGSHVATSIVA
THCDSAYYSDPLTFNPWRFVGAEDDAQDSKHRFATTSPEYLLFGYGRHACAGRFFAEIQL
EMMMAYVVTTYDVRMEKPGVLPEPIEFGSMSLPSMTAKVCFRKRATE
CYP512G2 Phanerochaete chrysosporium (white rot fungus)
JGI geme models pc.15.22.1 and genewise2nd.15.10.1
MFADSPTSLYALVLLGTVVYLLNWLKGSKYKSVPALGPTAPLLSYWGAIRFFLDAQGMLQ
EGQLKYGGSPFRIATRRYWQYIVSSPKLIDELRRAPDDELSFLDAVNEALELEYTMGAAT
ANNLYHVPVIRNTLTRNLGNLSSEIYDEISNAFADCIPARDEWMAVPALQSIMQIVARTS
SRIFVGLPLCRNREFLEISMTYTTDVVKTGLLLNMVPGPLKPIVNRLFSKVEQHIDRTHA
LLRPIIEERQRMMEQYGDDWPDKPNDMLQWLMDAAEGQEREPRALALRILIVGFAAIHTS
SMSFTQALYYLAAHPEYMQPMRDEVEAVLAAEGGWSKGALQKMRKVDSFLKECQRYEGLG
MLFLTRKAVKDFTFSDGTFIPKGSYVSTSRAATHGQSEYYRDPYVFDPWRFANLRDETGE
GVKHQMVNTSIEYLPFGLGKHACPGRFFAANELKSMMAHLVVTYDVALDMPGEVPRSVHF
GPINSPNRTAKVLFRKRRG
CYP512H1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.21.108.1
LQDIPTVGGPNLPFFSYFGAIHFLVRANKIISDGYSKYKGGSFKIAQVNRWLVFVTDPAL
NEELRKAPEDQMSSPAALHQYVQGLYTMGFGLDGMLYYIEVLRDQLLRHVNPSPAMLYDE
MQASFQDFIPQNTEWTPIPALSTSLKLFLRMSNRAFVGTPLCSNSEYLDLVTEFMNNVFK
GAFFYNCLPAFVRPILARWLDLVNPCLDRAVRLLTPIYATRVAELEAAGKAEWAGASDDL
LSCLVASHYSAARDVRELARILLVVNLAAVHTVSQSFTSVLFLLASRPAWQAELRAEAAA
ALAHGYTRDALARLRKLDSFVQESLRFNGLGALASTKLALTDFALSNGTVIPKGTLVSAP
LRALHLDDEVYPDGASFQPWRFVRAGGEAAPRQSLASTSPTYLPFGHGKSACPGRFFAAL
ELKMVTAYLVLNYDLKLEGDATEVPPVSWFITARVPNYKANVLVRRRQEKA
CYP512J1 Phanerochaete chrysosporium (white rot fungus)
JGI geme model pc.37.85.1
NIPTLGTEMPVLSLWGALRYVMNSHNVIQEGYLKYKGRPFKIAQFDRWLVVLTTPHHIEE
LRKAPETGLSSRDAVDSLLKAKYTLGMDVDTVQRYLDLFREKLANKLGGLTSEVHEEMEL
TLNESLPKSEDWEEFCVLPSILKILFRTTNRAFVGAPLCRSEEYVALGEEYTTNVFKGAV
IYNALPKALLPLLSKVLDFIGPTSRRCEQLFRPEMDKRAAYLEEHGADARGKYDDLLTWL
IATHGAGDEINYSELTRIVLIANLAAVHSTAMVFTFAIFHAAADPGVADALRAEVASVVA
EHGWTPTALTKMQRLDSFVREVQRMHTLGAALVMKIARTDYAFADGHVVPRGALVTAPAT
TVHRDDEHYPDAHTFRPWRFVGTPDESEADSARRKATSTSPTFLAWGHGKHSCPGRFFAV
RELKMLLGSVLLRYDVRLKTPGVLPQDQWYLTFRVPDPTACVLLKRRTTA
CYP512K1 Postia placenta (brown rot basidiomycete fungi)
CYP512L1 Postia placenta (brown rot basidiomycete fungi)
CYP512M1 Postia placenta (brown rot basidiomycete fungi)
CYP512N1v1 Postia placenta (brown rot basidiomycete fungi)
CYP512N1v2 Postia placenta (brown rot basidiomycete fungi)
CYP512N2 Postia placenta (brown rot basidiomycete fungi)
CYP512N3 Postia placenta (brown rot basidiomycete fungi)
CYP512N4 Postia placenta (brown rot basidiomycete fungi)
CYP512N5 Postia placenta (brown rot basidiomycete fungi)
CYP512N6v1 Postia placenta (brown rot basidiomycete fungi)
CYP512N6v2 Postia placenta (brown rot basidiomycete fungi)
CYP512P1v1 Postia placenta (brown rot basidiomycete fungi)
CYP512P1v2 Postia placenta (brown rot basidiomycete fungi)
CYP512P2 Postia placenta (brown rot basidiomycete fungi)
CYP512R1v1 Postia placenta (brown rot basidiomycete fungi)
CYP512R1v2 Postia placenta (brown rot basidiomycete fungi)
CYP512R2 Postia placenta (brown rot basidiomycete fungi)
CYP512R3P Postia placenta (brown rot basidiomycete fungi)
CYP512S1 Postia placenta (brown rot basidiomycete fungi)
CYP512S1P Postia placenta (brown rot basidiomycete fungi)
CYP512T1 confidential basidiomycete
CYP512U1 confidential basidiomycete
CYP512U2 confidential basidiomycete
CYP512U3P confidential basidiomycete
CYP512U4 confidential basidiomycete
CYP512U5 confidential basidiomycete
CYP512U6 confidential basidiomycete
CYP512U7 confidential basidiomycete
CYP512U8P confidential basidiomycete
CYP512V1 confidential basidiomycete
CYP512V2 confidential basidiomycete
CYP512W1 confidential basidiomycete
CYP512X1 confidential basidiomycete
CYP512Y1 confidential basidiomycete
Note, see lower eukaryote section of homepage for dictyostelium P450
Accession numbers, other identifiers and sequences. There are currently
25 complete sequence from Dictyostelium including CYP51 and CYP508 families.
CYP513A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 8+53.
CYP513A2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 38.
CYP513A3 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 7+50.
CYP513B1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 49.
CYP513C1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 5+56.
CYP513D1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 54+55+78.
CYP513E1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq seq 51+52+90 ng3101.
CYP513E2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 37a.
CYP513E3P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 37b upstream of 513E2P only 429 bp between
CYP513F1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 57.
CYP513G1P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 41.
CYP514A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 11
CYP514A2 Dictyostelium discoideum (cellular slime mold)
GenEMBL AB050504 C-term only
See lower eukaryote section for more accessions and sequences
Formerly seq 65
CYP514A3P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 89
CYP514A4 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
ng2792 only 7aa diffs to 514A1
CYP515A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 79b
CYP515A2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 79a
CYP515B1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 6
CYP516A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 9+43
CYP516A2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 64
CYP516B1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 10+42
CYP516B2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 48
CYP517A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 3+61
CYP517A2 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 74
CYP517A3P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 36
CYP517A4 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
ng5440 most like 517A1, 13 aa diffs
CYP518A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 20
CYP518A2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 25+27+29+30
CYP518B1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 26+28
CYP519A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 12
CYP519B1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 35+44+75
CYP519C1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 31+32+33
CYP519C2P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 46
CYP519D1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 14+34
CYP519E1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 17+84
CYP519F1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 47+68+80 renamed from CYP520A1
CYP519G1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 58 renamed from CYP520B1
CYP519H1P Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 39+73 renamed from CYP523 full length pseudogene
CYP520A1X Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 47+68+80 renamed CYP519F1
CYP520B1X Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 58 renamed CYP519G1
CYP521A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 13
CYP522A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 18
CYP523A1X Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 39+73 renamed CYP519H1P full length pseudogene
CYP524A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 91
Note: this seq is 34% identical to CYP710A1 and A2 from
Arabidopsis. That is the same identity between dicty CYP51 and
human CYP51. Therefore, the CYP710 seq may have shared a common
ancestor with CYP524A1 that was independent of CYP51.
CYP525A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 62
Note Dictyostelium names continue with CYP554A1 - CYP556A1
CYP526A1 Fusarium sporotrichioides
GenEMBL AF330109
Peplow,A.W., Tag,A.G., Garifullina,G.F. and Beremand,M.N.
Identification of genes under the control of TRI10
Unpublished
Clone name TRI13
Not very similar to any other named P450
34% identical to rice blast fungus AQ361801 from
Magnaporthe grisea GSS sequence from BAC clone
CYP526A2 Gibberella zeae strain HKM136 (same species as Fusarium graminearum)
GenEMBL AY057841.1
cytochrome P450 (TRI13)
82% to 526A1
note: this sequence not found in Fusarium graminearum genome assembly
809 MFLSIGLVAVALYLLYRWALPKPISSIPYNPLALQSLFGDIPAMMKWTNASKQSHMEWII 988
989 QQMKNHESPIIQLFLKPLGNPVVILADFRETQDIMLRRKEFDRATNARALLEDVIPDHHL 1168
1169 YEQTNSIFRTHRKLVQDVMLPSFIQKVAGPCFHSNIMRLVRVWELKAEIANGSPFLATQD 1348
1349 IQGAVLDAVYTFAFGEYYKSSTTLPNIEILEKLNNSQNSKSDKPVDFPDVAFDD 1510
1511 LITATIDLAKAPQGVQSSPIAKVQSKVLMNMPYFRRVRKIRDDFLRGSLRSAVSKLQSEN 1690
1691 GLSDSPPVTSALEQMVLRETLLAKAENRSPNYLSTMMQGE (0) 1810
1873 LFGLILGGYDTTSTTTLWGLKFLTGNAGAQKRLRQALQSAFPKAKSENRSPTFQELAAAR 2052
2053 IPYLEAVIEESLRCGGATSALQRLAMVDTQILGHHIPKGTEILFLTHGPSVFTPGLEIDE 2232
2233 RKRSQTCQVAGEKKDSAWDDHDIGAFKPERWLRQKESSTGTDATEAAEEFDGLAGP 2400
2401 TLAFGLGTRGCFGRRLGHQQLRTSLAILIWNFELLPCPKELSSYRAIEGLTSMPEHSYIS 2580
2581 LAKVDLT 2601
CYP526B1 Neurospora crassa
GenEMBL WGS section AABX01000480.1
100% match to XM_330285.1 mRNA prediction
38% to 526A1 (TRI13 gene)
38% to AACM01000167 Gibberella zeae
See fungal pages for seq
CYP526B1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_150007
94% to CYP526B1 N. crassa
See fungal pages for seq
CYP526B2 Grosmannia clavigera
CYP526C1 Magnaporthe grisea
MG01353.4 39% to 526B1, 39% to MG07551.4
AACU01000036 cont2.245
See fungal pages for seq
CYP526D1 Magnaporthe grisea
MG07551.4 poor match 39% to MG01353.4
AACU01000913 cont2.1400
See fungal pages for seq
CYP526E1 Fusarium graminearum
FG03860.1 AACM01000167 FGcontig1.167_scaffold2
See fungal pages for seq
CYP526E2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_25000035
Necha1/scaffold_25:100712-102551
60% to CYP526E1 possible ortholog
See fungal pages for seq
CYP526E3 Fusarium oxysporum
68% to CYP526E1 Fusarium graminearum
Seq runs into a seq gap. One frameshift = &
See fungal pages for seq
CYP526E3 Fusarium verticillioides
92% to CYP526E3 Fusarium oxysporum = ortholog
70% to CYP526E1 Fusarium graminearum
See fungal pages for seq
CYP526F1 Fusarium graminearum
FG10629.1 AACM01000446 FGcontig1.446_scaffold7
See fungal pages for seq
CYP526F2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.8.241.1
Necha1/scaffold_8:592224-594069
58% to CYP526F1 possible ortholog
See fungal pages for seq
CYP526F3 Fusarium oxysporum
69% to CYP526F1
See fungal pages for seq
CYP526F3 Fusarium verticilloides
93% to CYP526F3 Fusarium oxysporum
See fungal pages for seq
CYP526G1P Fusarium oxysporum
40% to CYP526F1, first exon is about 6000 bp upstream and
second intron boundary is defective. probable CYP526 pseudogene
See fungal pages for seq
CYP526G1 Fusarium verticilloides
78% to CYP526-un1 Fusarium oxysporum, 40% to 526E2
See fungal pages for seq
CYP526H1 Aspergillus terreus
38% to CYP526A1, 13 of 17 top hits are CYP526 members.
Three others are CYP5134 members.
See fungal pages for seq
CYP526J1 Metarhizium anisopliae var. acridum Ma102
CYP526J1 Metarhizium anisopliae var. anisopliae Ma23
CYP527A1 Neurospora crassa
AABX01000356.1 cont3.332 NCU05848.1 (version3)r
Neurospora crassa sequence contig 1.73 (supercontig 9)
b2f20.tfa_120wg@B2F20 there are two P450 genes on this contig
MLQELLSLAQGPYALPILAASLVAYLLVSITITYRRLSHFPGPFLASFSPLFMLKVLFSGHHADGYSRLNQQYQS
PLVRIGTTDLITDDPAIIRHMNGARSAWGRSNWYRAMTLDPRGGSLFDEPNTKTHDLFKARLSFGYSGRENPGLE
GDIDEVIGMLIQYIKSRYISDDERGVLKRMDLAKVTQFFTLDVITRIAYGKEFGWLKTDKDQFEWTSTVIKAVPA
NSLIAELPLLQKIFLSKWFLQWFGPKHSDANGMG
162022 RVMGMAREMVAKRFGEKAEDRKDMLGSFVRHGIEQQACEVEVLFQILAGSDTTAVAI 162192
162193 RSTFFHLATSKKAYVRLLEEIDRAVKEGEVSSPIRAEEAKHLEYLQACVYEGLRMQAPFS 162372
162373 GLCMKSPPKGGDFINGMFIPEGTRVGHNFGGLIRRRDVFGEDADVFRPERWL 162528
162529 NAEPAKRLEMQQTTEMVFGYGRWACLGKPVALMELSKVFFE 162651
FFRRFDLQLVEPKNPWHEFNVNMCFQSDLWVKITERFPEGEKV
CYP527A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_90116
92% to CYP527A1 N. crassa
See fungal pages for seq
CYP527B1 Neurospora crassa
AABX01000074.1 cont3.486 NCU08112.1 (version3)
Neurospora crassa sequence contig 1.1433 (supercontig 257)
42% to CYP527A1 over 514 aa same family different subfamily
MASLGGFFDPSRLTTAS
PKAILITTFSLLIVYYITSSIIAWYRLRHFDGPWLGKFSYLWIFKIIHSGQMGEAAHAAQ
DKYGGVEPGYPSTVRIGPSDLITTELDLIRRMSGARSRYTRSDWYKLNRLDPYDDNMFS
TTSTTYHDKLKSKMAPGYAGRDNTGVEKDIAHVISKLVDKIRTKYAAPKGSTSPAGREM
LEFGQMAQYFTLDVICKTAFQVEFDHITKEEDVFGYIYMVHNLVYGNAMGATIPIIGKVL
SNPLFLKMFGPTTKDPRGMGLIMK (2)
VAREIVAKRFAPDAKDQQDML (0)
GSFIRRGLTQRQCETESIFQILAGSDTTATGIRSGLLYLCSNPRAYTRLQRE
IDERIASGLISSPCITNAESLAFPYLQAVIYESLRMRPPFDGLPFKIVPPEGDYTRDGKF
IPGGTKITATFGAMQRNKEVFGVDSDIWRPERWLEEEGCDAERRREMKSVVEMVFGYGRW
QCAGKMVAMLELNKIFCQ (0)
LMRNFDFQLANPTQPWKSRNYHIFFHDDFYLTVTDRHSKTEDEKSS*
CYP527B1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_20111
96% to CYP527B1 N. crassa
See fungal pages for seq
CYP527C1 Magnaporthe grisea
GenEMBL ESTs BM871448.2, BM863551.2, BU644850.2
CD036984.1, BM870914.2, BM869571.2, BM871829.2
46% to 527A1, 45% to 527B1, 43% to 527D1
MMLQQVADALATHWLSGILAIATVYLATSYIIDYRRLR
AFPGPPLGSFSYLWLAYNALQGRQGSIFYEVMKRYRVPEHSFVRIGPNDLMTDSPEVVRHMS
SARSTYLRSSWYRTSKLDPSGDSLLSIMDTAHHDALKAKAGRGYAGRDNRNLESDIDDQL
RRLIGLLERKYLSGGGDASSFRPVDMATTMQYFTLDSITKLAYSSAFGFLDLDTDVYGYI
KAIRDAAPPIIVCSEWPLAGRIFFSPPFLKMFGPTPKDKSGVGKLMGTLRQVVASRFGPDA
KDQPDMLGSFVRNGLSQHQCEQEVILQIVAGSDTTATALRGTLLQLCSTPMVYLKLQKEI
DEAVRSGMVGEGVISQETARKLPYLQAVIYEGLRLNPPFTGALMKEVPPGGDEIDGVFIPAG
VRIGVSAKGIQMRQDVYGHDVDVFRPERWTECDEQRRMRMAANTELVFGYGRWMCAGKNVAFME
LNKVYFELLRRFDFQVVDTKTPVKEESFNVMVSKDMFMKVTKRVLYTGSILIRAR*
CYP527D1 Botrytis cinerea
No accession number
Verena Siewers
Submitted to nomenclature committee Dec. 11, 2003
46% to 527A1, 43% to 527C1, 42% to 527B1
seems to be missing C-terminal
CYP527D1 Botrytis cinerea = Botryotinia fuckeliana
GenEMBL AJ609392.2
join(<935..1716,1765..1828,1878..2111,2195..2515,
2575..2703)
aba1 gene
43% to 527E1, 43% to 527A1, 41% to 527B1, 41% to 527C1
MSNSILNLGSFACLLSLGSIVLWYTISAVLAWYPLRKIPAPSFL
ATFSYLWLAKTTYSGKQYWIQRDLHKKYGPLVRIGPTDIITDDPEIIKKISSARSSHR
RGDWYLTGRFNPYYDNMFTMLEPGPHAKAKARTAAAYSGRDMPDLEVGVNAQLQTLIG
LMRSKYASNTVKPHQPLLDLGQVSCFFTMDVITRLAFGEEFGYLKEETDQYGFLGEVR
ELWPRMSTSADTPWIRKFLFSPPFLKVLGPKPTDKTGFGALMAVAEHHVGKRFAPDAK
KKEDMLGSFIRHGLNQQECEVEGLFMIVAGTESTASAIRSTLVHVMTCPRVYQKLKTE
INLAVEEGKVSSPIKLEEAKLLPFLQAVIYEGIRMRPPLLGLFPKIVPDGGEEFHGMF
IPAGTAICMNTSSLLRSTALFGDDAEVYRPERFMELEKSKRGEMERNVELAFGYGQYM
CVGKTVAFMELNKSIFEILRAFDLQLLSPAKPCDVLSYGIFLESNMLVKVTESEGTEYK
CYP527D2 Aspergillus niger
JGI gene model e_gw1.21.29.1|Aspni1
59% to CYP527D1
See fungal pages for seq
CYP527E1 Fusarium graminearum
FG01767.1 AACM01000092 FGcontig1.92_scaffold1
See fungal pages for seq
CYP527E2 Fusarium oxysporum
70% to CYP527E1 Fusarium graminearum
See fungal pages for seq
CYP527E2 Fusarium verticillioides
92% to CYP527E2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP527F1 Fusarium oxysporum
51% to CYP527E1 Fusarium graminearum
See fungal pages for seq
CYP527F1 Fusarium verticillioides
89% to CYP527F1 Fusarium oxysporum = ortholog, one frameshift
See fungal pages for seq
CYP527F2 Fusarium oxysporum
52% to CYP527F1 Fusarium oxysporum
See fungal pages for seq
CYP527F2 Fusarium verticillioides
90% to CYP527F2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP527G1 Metarhizium anisopliae var. anisopliae Ma23
CYP528A1 Neurospora crassa
No accession number
Neurospora crassa sequence contig 1.73 (supercontig 9)
b2f20.tfa_110wg@B2F20 there are two P450 genes on this contig
MSLPTLQDVLATSISLLKTTTPLLKRITSLLLKTTTSLLFIIVVTILAIAVYRLFFHPLAGIPGPRLAALSNIWH
AYHARNGRMYLLGKSLHKRYGPVVRVGPNELWFDSKEAFKTIYSAGSGFEKSDFYLSTLLTKPTLSLKFSPFKFP
FPNLQLPLQIHHPDTLDLLSERHLPRYRLQRRLIGPLYQLSSLKKFEPQIDAVLDRAIAQLRTLQGQEVDLKEWM
HIIAVECLGAVVLSWSPGYIRDKSDGGTSVQGYLGWKRKSVFGLFPGITILSFLEGGPFGLGERMGKGVARWWSN
TWGVTFATPKGFKPFFTAVYQKVSRRVSMAALLWMSDEVKVVKKPSSKKNKPAKGKMEEDKGKKDLLEDLIKLYQ
SKPEQFTETYLRRMAMTNFGAGHETLCSALTACMAMIGTHAAVQARVAEEVGSHLRGGGTVPFDTAAKQLPYTLA
AIKEAQRLHPVIAMSLSRTVPRDLDGGGVMLHGHWVPEGTTVGCNPVALHRNQEIFGEDADSEPEPTPNSEPAPV
PESVSGSPSEPDSDPKPEPNSAPKHQQPNLHPTPEQEEEEEEVERKRLREMLHLNLTYGGGARTCPGRHLAELIV
WKVIPRLVAEFRVEVTHMPRDEEKNMERYFMSMLTGVKVRFLERREDSGDMA
CYP528A1 N. crassa
AABX01000356.1 cont3.332 NCU05849.1 revised
appears to have a 14 aa insertion in the beginning of exon 3
8219 MSLPTLQDVLATSISLLKTTTPLLKRITSLLLKTTTSLLFIIVVTILAIA
VYRLFFHPLAGIPGPRLAALSNIWHAYHARNGRM YLLGKSLHKRYGPVVR
VGPNELWFDSKEAFKTIY (1) 7866
7779 SAGSGFEKSDFY (1) 7744 remove
7659 LSTLLTKPTLSLKFSPFKFP
FPNLQLPLQIHHPDTLDLLSERHLPRYRLQRRLIGPLYQLSSLKKFEPQI
DAVLDRAIAQLRTLQGQEVDLKEWMHIIAVECLGAVVLSWSPGYIRDKSD
GGTSVQGYLGWKRKSVFGLFPGITILSFLEGGPFGLGERMGK add
7173 GVARWWSNTWGVTFATPKGFKPFFTAVYQKVSRRVSMAALLWMSDE (0) 7066
6953 MEEDKGKKDLLEDLIKLYQSKPEQFTETYLRRMAMTNFGAGHET
LCSALTACMAMIGTHAAVQARVAEEVGSHLRGGGTVPFDTAAKQLPYTLA
AIKEAQRLHPVIAMSLSRTVPRDLDGGGVMLHGHWVPEGTT
VGCNPVALHRNQEIFGEDADVYNPSRWLP (1) 6490
6154 LERKRLREMLHLNLTYGGGARTCPGRHLAELIVWKVIPRLVAE
FRVEVTHMPRDEEKNMERYFMSMLTGVKVRFLERREDSGDMA* 5897
CYP528A1 Neurospora discreta
JGI gene model scaffold_9-snap.53.1
81% to CYP528A1 N. crassa
gene model does not appear to be assembled
correctly. Two sequences removed.
mRNA may be needed to decide this assembly.
See fungal pages for seq
CYP528A2 Fusarium graminearum
FG02458.1 AACM01000122 FGcontig1.122_scaffold1
See fungal pages for seq
CYP528A3 Magnaporthe grisea
MG03500.4 49% to 528A1 AACU01000719.1 cont2.687
54% to AACM01000122.1 Gibberella zeae
See fungal pages for seq
CYP528A4 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.18.26.1
Necha1/scaffold_18:578149-579878
74% to CYP528A2 probable ortholog
See fungal pages for seq
CYP528A5 Mycosphaerella graminicola
54% to 528A2 N-term from JGI model estExt_fgenesh1_pg.C_chr_70267|Mycgr3
See fungal pages for seq
CYP528A6 Mycosphaerella fijiensis
63% to CYP528A5 Mycosphaerella graminicola
estExt_Genewise1Plus.C_110131 revised
See fungal pages for seq
CYP528B1 Metarhizium anisopliae var. acridum Ma102
CYP528C1 Grosmannia clavigera
CYP529A1 Neurospora crassa
No accession number
Neurospora crassa sequence contig 1.73 (supercontig 9)
EST c1b06np.r1 (lower case)
METSNLTLLLLYLAIPSLLISAVQQILSWRKRTALVGSSGSKAKFPGPRQFPIVGRIHDLPRFSLWLK
FKEWADEFGPIYTTSVPDATFVIISDEKIAEELLVKRGHIYSGRPQIRSLIGHKEGVVYSALMDRH (1)
DTWKSQRKWAHAAMAAAYKHHFYGHVESemrrflvvllfdpdrfldhtreycgrvmsrlawddatqgrln
gesadktlhcmsvsgpitntmtplwslpasinpwykyevkreaelrqwwlglfrkakermrkgelpsdtwayryfeqmvqdtapsmpataRAPGPDVKNAERSPSTAAQEEAYEKKDALDQPEKDETFASCMIGFLNLVGVVTISGPLKFFQMAMALHPEWQHKAQAEIDEVCGDRMPTMKDFDKLPILRAC
LKETVRWRSGVPLGVPHQAERDDEFRGVKIKKGTIVLACEW (2)
TLNRNPQKYPDPETYNPARYLDPSYPTFQAPLTRYPNFREGSSMHSFGWGRRTCLGQNIVDDEMFVFGAALLWAF
EVTPKTCPVTGKEVPIDTHKTNSHVILEPVDFQLGYKVREGKKELILEGGKEFFGKV*
CYP529A1 Neurospora crassa
AABX01000356.1 cont3.332 NCU05874.1 (version3)
88106 METSNLTLLLLYLAIPSLLISAVQQILSWRKRTALVGSSGSKAKFPGPRQ
FPIVGRIHDLPRFSLWLKFKEWADEFGPIYTTSVPDATFVIISDEKIAEE
LLVKRGHIYSGRPQIRSLIGHKEGVVYSALMDRH (1) 87705
87637 DTWKSQRKWAHAAMAA
AYKHHFYGHVESEMRRFLVVLLFDPDRFLDHTREYCGRVMSRLAWDDATQ
GRLNGESADKTLHCMSVSGPITNTMTPLWSLPASINPWYKYEVKREAELR
QWWLGLFRKAKERMRKGELPSDTWAYRYFEQMVQDTAPSMPATARAPGPD
VKNAERSPSTAAQEEAYEKKDALDQPEKDETFASCMIGFLNLVGVVTISG
PLKFFQMAMALHPEWQHKAQAEIDEVCGDRMPTMKDFDKLPILRACLKET
VRWRSGVPLGVPHQAERDDEFRGVKIKKGTIVLACEW (2) 86729
86660 TLNRNPQKYPDPE
TYNPARYLDPSYPTFQAPLTRYPNFREGSSMHSFGWGRRTCLGQNIVDDE
MFVFGAALLWAFEVTPKTCPVTGKEVPIDTHKTNSHVILEPVDFQLGYK
VREGKKELILEGGKEFFGKV* 86262
CYP529A1 Neurospora discreta
JGI gene model estExt_fgenesh2_pg.C_90006
96% to CYP529A1 N. crassa
See fungal pages for seq
CYP529A2 Magnaporthe grisea
MG00832.4 66% to 529A1 AACU01001468 cont2.149
See fungal pages for seq
CYP529A3 Grosmannia clavigera
CYP530A1 Neurospora crassa
AABX01000046.1 cont3.150 NCU02852.1 (version3)
Neurospora crassa sequence contig 1.85 (supercontig 11)
b10d6.tfa_160wg@B10D6
MAVITTYLPIVVGIALLIRLLMVGRRPKNYPPGPPTIPILGNLHLMPTKDVHLQFEKWAREYGPVYSLILGTKVM
VVLSSDRAVKDLLDKKSHMYSHRQEMYVGQTLCSGDMRILMLGYTAKWRMSRKLVHALLNVSSAKSYVPYQMLEN
KQMLYEMITKPDEFLYNIRRYSNALTTTMVYGWRTPTYNDEKMRQLFDGFSEFAEINQTGVAALIDFFPILRYLP
DFLLPARKKAKELHKKELGLYKGHWLKAKEVTLKGTITHCFCEDAVPVQKKEGFSDDEAAYIAGTLLEAGSDTTS
STLYGFVQAMLLYPEVQRKAQEEIDRVVGPDRLPTMDDEPHLQYCRAIVKESLRWMPTTIMGAVPHAVTQDDYYN
GYLIPAHAAVVNNAWAINHDPVRAPEPRKFKPERHLDDKLSLADSAANPDPTKRDQFTFGAGRRICPGIHVAERS
LFLGVARMLWGFSIAPKIGVDGKEIIPDQEKLTQGFVCMPEEYPATITPRDERRKGIMEEEWFAAERECLDPETK
QWKQGMNWVPKLSSTKV
CYP530A1 Neurospora discreta
JGI gene model e_gw1.4.267.1
89% to CYP530A1 N. crassa
See fungal pages for seq
CYP530A2 Fusarium graminearum
FG11389.1 AACM01000465 FGcontig1.465_scaffold9
revised, 77% to CYP530A5, 76% to 530A9
See fungal pages for seq
CYP530A3 Aspergillus nidulans
AACD01000151.1
revised 7/19/07
MLPLTPILAIAGLLALIFRLSLIGRRPKNYPPGPPTLPLLGNIHQMPSRD
AHLQFAKWAKEYGPIYSLMLGTQCLIILSSDEAVKELLDRRSGIYSHRQE
MYTGQQLCSGGLRMLMMGYGPTWRIMRKMVHGLLNVSTSRNYIPYQMLEN
KQMLYQFLTEPDDFLKHIRRYSNALTTTMVFGWRTPTYEDPKMKQLFDGF
SEFAEINQAGAAAFLDFFPLLQKLPDFLVPTKRKAKELHKHEMGLYKGHW
MKAKEEIEAKNIKPCFCQGMYEVQKKEGFSDDQAAYISGTLLEAGSDTTS
STLYAFVQAMLLYPEIQRKAQAEIDRVIGPDRLPVMDDLADLQYIRSCMK
ETLRWMPTTILGAVPHAVTQDDSYMGYFIPKGAGVMNNVWAIHHDEKRHP
NPRQFNPDRYKDDTQSLGDAAANPDASKRD
AFTFGAGRRICPGIHVAERSLFLGMSRILWAFNISPKKDASGKEIIPDQERLTQGFVCMP
EEFPATITPRDEKRAEMVRNEWRQAEKELDSETKQWVVAPVDIKI*
CYP530A4 Nectria haematococca (Fusarium solani group)
e_gw1.14.490.1
Necha1/scaffold_14:351965-353894
49% to CYP530A2 possible ortholog
See fungal pages for seq
CYP530A5 Aspergillus fumigatus
GenEMBL AAHF01000014
complement(join(613367..614597,614640..614689,
614717..614932))
locus_tag="Afu8g00760" third P450 of 8 on this accession
53% to CYP530A4, 73% to 530A2, added missing first exon
to the annotation in Genbank
MLPLALVGAVGALVFLVFRLLSIGRRPKNYPPGPPTLPIIGNIHQ (0)
MPTRDAHLQLQKWAQEYGPVYSLILGTKPLIVLSSDQAVKALLD
KRSALYSHRQEMYIGQTLCSGGLRMLMM (0)
GYTPVWRG (0)
FRKMVHGLLNV
TAAKSYVPYQMLENKQMMYEFLTQPERFLYSIRRYSNALTTTMVFGWRTPTYEDAKMK
QLFDGFSEFAEINQTGTAALIDFFPWLRMLPDFLLPTQKRAKELHEREKALYLGHYLR
AKQDIRDGQIKPCFCVGLAEAQKSDGFSDDQAAYISGTLLEAGSDTTSNTLYAFVQAM
LLFPDVQRKLQEEIDRVVGPRMPTMDDEQDLQYVRACMKETLRWMPTTILGAVPHAVT
QDDEYMGYLIPKGAGVVNNVWAIHMDEKRHPNPRVFNPDRYKDDRQSLAEAAANPDAT
KRDQFTFGAGRRICPGIHIAERSLFLGISRMMWAFNVEPAVDEKGQPILPDPDRLTQG
FVCMPEEFPARITPRSQAKADMVIKEWKEAEQQCLDPETKQWLLSPVQ*
CYP530A5 Aspergillus fumigatus
GenEMBL XP_747129.1 also EAL85091.1
Sequence not assembled correctly
CYP530A5 Neosartorya fischeri
95% to CYP530A5 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP530A6P Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.10.737.1
Necha1/scaffold_10:90207-90395
pseudogene
37% to 530A2, 38% to 530A4, pseudogene pieces
See fungal pages for seq
CYP530A7P Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_44000004
Necha1/scaffold_44:12309-13331
pseudogene
43% to 530A2, EXXR motif mutated to KTFR probable pseudogene
See fungal pages for seq
CYP530-un1 Nectria haematococca (Fusarium solani group)
Pseudogene 39% to 530A3, 37% to 5056A1, 35% to 5047A1,
four stop codons
the affiliation of this pseudogene is not clear
genome annotation in progress
CYP530A8 Mycosphaerella graminicola
66% to CYP530A3 Aspergillus nidulans
probable assembly error in the yellow region (or a pseudogene)
green from JGI model restores EXXR motif, cyan may be intron seq
See fungal pages for seq
CYP530A9 Uncinocarpus reesii
78% to CYP530A3 Aspergillus nidulans, 79% to 530A5
See fungal pages for seq
CYP530A10 Coccidioides immitis
88% to CYP530A9 Uncinocarpus reesii
See fungal pages for seq
CYP530A11 Fusarium oxysporum
87% to CYP530A2
See fungal pages for seq
CYP530A11 Fusarium verticillioides
96% to CYP530A11 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP530A12 Fusarium verticillioides
53% to CYP530A3
not found in F. oxysporum genome
See fungal pages for seq
CYP530A13 Grosmannia clavigera
CYP530-un1 pseudogene Nectria haematococca
JGI gene model gw1.271.3.1
Necha1/scaffold_271:2439-4371
35% to 5047A1
39% to 530A3, 37% to 5056A1
See fungal pages for seq
CYP530-un1 Aspergillus terreus
64% to CYP530-un1
See fungal pages for seq
CYP531A1 Neurospora crassa
AABX01000205.1 cont3.366 NCU06327.1 (version3)
Neurospora crassa sequence contig 1.111 (supercontig 14)
MDSHAGLDGVLQPQVLKLTLRTLPSPFISFVVIPI
28695 LSILGWYIISWATNPLKKYPGPFLAG (1) 28775
FTNWWRLYQTRTGRYHEIVYDLHKKYGPIVRIGPNTLDLDYPELIKTIYSTDGKWLK (0) 29023
29083 TEFYHNNSAIVNGKITYHIFSTTSPTEHAKMKRPVAKYYSTSYVQALEPHVDVVLNDFCK 29262
29263 YVEERFINVPGGPKELDFGEWLGYRN (2) 29343
SVTFSRRFGYMEHGSDFDGTIEKAEAALRYFQTVGQIPILD 29555
29556 YFLDKNPIKRVGPPNLVHPARIA
29625 VQSFVARLQGKDENYDPKNPDYLQHFIDSKESHPDLVDDNQIISDVLVNLLAGADTTAIA 29804
29805 LRAVFYYMLKNRSVYNRVSEEIQAAGFDRSKPVPYSGARQLPYLEACVREALRIHPAA 29978
29979 AMLLERYVPADGITLPDGSFVPAGTAVGLNPWVVSRNKSIFGEDSDTFRPERW 30137
30138 LQQPGEDDEAFHVRMQKWNAADLTFGNGSRICTGRNFAMFELYKVCATLLHRFEIEL 30307
ADPTKEWKVWGSWFTIQKDVIAKMKVRG*
CYP531A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_30974
96% to CYP531A1 N. crassa
See fungal pages for seq
CYP531A2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_15000295
Necha1/scaffold_15:796534-798330
60% to CYP531A1 probable ortholog
See fungal pages for seq
CYP531A3P Fusarium oxysporum
51% to CYP531A2 Nectria haematococca
See fungal pages for seq
CYP531A3 Fusarium verticillioides
80% to CYP531A3P Fusarium oxysporum,
probable ortholog to the pseudogene
See fungal pages for seq
CYP531A4 Fusarium verticillioides
83% to CYP531A2, 49% to CYP531A3P
no ortholog in F. oxysporum
See fungal pages for seq
CYP531A5 Fusarium verticillioides
62% to CYP531A2 Nectria haematococca
62% to CYP531A4 Fusarium verticillioides
57% to CYP531A3P Fusarium oxysporum
no ortholog in F. oxysporum
See fungal pages for seq
CYP531A6 Grosmannia clavigera
CYP531B1 Magnaporthe grisea
MG07856.4 44% to CYP531A1
AACU01000959.1 cont2.1455
Name changed from CYP569A1
See fungal pages for seq
CYP531C1 Fusarium graminearum
FG02982.1 AACM01000145 FGcontig1.145_scaffold2
See fungal pages for seq
CYP531C2 Nectria haematococca (Fusarium solani group)
e_gw1.27.133.1
Necha1/scaffold_27:386590-388379
76% to CYP531C1 probable ortholog
See fungal pages for seq
CYP531C3 Aspergillus oryzae
GenEMBL BAE65935.1
58% to 531C2
MDSFLFLALDYSLRGFAVSLFGTLWIALVFWYLATYLISPLRKIPGPFLAGWTNLWRMYHVTQGQSQVVL
HELHQKYGPVVRIAPNVVDLDLPEMIKTIYNTKGDYRKTEFYHGSSAKSNGRIIYNLFSECDPDIHAQQK
RPIAKYYSLTGVLPLEPHIDEVINYLCQRLEEEFINGLNAGITCKLDQWLLFYTWDVVGQATFSEPIGYL
KNGFDFDGTIAISDTAMDYFSLVGQLPVLDHLLDKNPIYRIGPPAFGNITNISITHLLDRLQGKDTSYHD
ANKPDFLDRFIDAKDKYPDIVDDSQIISYLMINMIAGADTTAITLNAAIYFALKDRRVWARLQKEIRACQ
SSLDAAPSAVPYNIASALPYLNAVVREAMRMHPGVAMTLERYVPPGGLTLPNGQYIPQGSIVGMNPYVIA
RNRSVWGEDSDVFRPERWLRDDSQESEEEFQARLRLMNNSDLAFGAGSRICIGRNLGLLEVYKVMATLIS
RYDIELAHPHRDWKTHNSFFVRQEGINVKLSRRS
CYP531C3 Aspergillus flavus NRRL3357
AAIH02000016.1
98% to CYP531C3 = ortholog
See fungal pages for seq
CYP531C4 Aspergillus fumigatus A1163
ABDB01000058.1
94% to CYP531C4 Neosartorya fischeri
See fungal pages for seq
CYP531C4 Neosartorya fischeri
72% to CYP531C3
94% to CYP531C4 Aspergillus fumigatus
See fungal pages for seq
CYP531C5 Aspergillus terreus
65% to CYP531C4 Neosartorya fischeri
See fungal pages for seq
CYP531D1 Fusarium graminearum
FG09351.1 AACM01000383 FGcontig1.383_scaffold6
See fungal pages for seq
CYP531D2 Aspergillus nidulans
AN5665.1 52% to 531D1 53 clan looks intact
See fungal pages for seq
CYP531D3 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.20.308.1
Necha1/scaffold_20:255173-256867
76% to CYP531D2 probable ortholog
See fungal pages for seq
CYP531D4 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.3.1764.1
Necha1/scaffold_3:3276976-3278701
53% to CYP531D2
See fungal pages for seq
CYP531D5 Fusarium oxysporum
86% to CYP531D1 Fusarium graminearum
See fungal pages for seq
CYP531D5 Fusarium verticillioides
98% to CYP531D5 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP531D6 Aspergillus clavatus
72% to 531D2
See fungal pages for seq
CYP531D7 Metarhizium anisopliae var. acridum Ma102
CYP531D7 Metarhizium anisopliae var. anisopliae Ma23
CYP531E1 Aspergillus oryzae
BAE63827.1
45% to 531D2, 40% to 531D1, 39% to 531C1, 40% to 531A1
44% to 531D4, 42% to 531D3, 38% to 531C2, 37% to 531B1
MLSITELIMDLGLAIVILGVSHLLWNYLSSPLKAFPGPLWASFTNLWRLQDVFKGRCDITHNQLHRKYGT
AVRMGPKVLSLSDPSVIPHVFNSKNPWMKSDMYNVNDVIVSGVRLKNLFSHQDEKWHSTYIRPVKGLYSM
TKVQDMEPGVDVTINLFMDKLRERFVEKGQLCDMADYLNFFAWDVMSQITFSQNLGILEAGSDYQGFLGR
SNKSLDYFASISQMPILDLLLDKNPIVRLGPPTFVWANIFSLEQLQKRLSGGTPPSGHTDFLDKFLETKK
KYPDLVNDNTVVTYLLSNTLAGSDTTGSAMCSAVYHILKHPRVHRKLREELYAAKVPLPAKWKDLQGLTY
LDAVMRESMRVNPGVGLMIERIVPEGGFTLPDGRFIPAGTIVGMNPWVINKNEAIFGANTEEFIPERWLP
SPGESDQAYQARFTKMKSTDFTFGAGPRMCMGRYLSQLESYKLIATLFSTFEMELPSLDHTWHVTNSWFV
RHKSIPVKMRERTDLAVSV
CYP531E1 Aspergillus flavus
99% to CYP531E1 Aspergillus oryzae
See fungal pages for seq
CYP531E2 Aspergillus oryzae
BAE59053.1
52% TO 531E1, 40% to 531D2
60% to 531E1 after making adjustments for gaps
revised 3/19/2009
MDIAFKLVLLGATLILSHLIWNYFRSPLKSFPGPFSANLSNLWRLQDVFKGLCDITHNELHRRYRSAVCI
GPNVLSLSDPALINQVYSTRDPWVKVSSERTQDPQHSDVYNVNDSVVSGVRIKNLFSHQDEQWHANQELE
PGVDITINLFLE
SEYINY (1)
FTWDTMSQLSYSQSIGMLEAKNDRFGILEVSNRSLDYFAS
VCQIPMLDLLLDKNPICRLGPPSFGWSVKFSAEQYQERFTEGKQSHNGIKDFLDRYIETKSKMPNIVDDN
VAQMYLVLNIIAGSDTTARAISAAVYYEELRGANLSTPPQWKEIRSLPYLDAVMRETMLVHPGVGLLLERIV
PKGGFTLPDGRFVPEGTIVGMNPWVINRNRTVFGPEPDSFKPERWLPAEGEHDEAYQTRFSKMKGTDLTF
GAGPRACLGRYISQLESYKFVATLFTMFD (0)
LEHPDHEWEVTNSWFVRQKNIPV (0)
PSSSSSSLVVSL*
CYP531E2 Aspergillus flavus
99% to CYP531E2 Aspergillus oryzae
See fungal pages for seq
CYP531F1 Chaetomium globosum CBS 148.51
XM_001227270.1 revised C-term
53% to CYP531A2
See fungal pages for seq
CYP531F2 Chaetomium cupreum EST
DV545173.1
86% to XM_001227270.1 Chaetomium globosum
LSMMEVYKVVPTLLAAFDVELVDPEEKWWTCSRWFYRTKGVICRLKPRST*
CYP532A1 Neurospora crassa
AABX01000767.1 cont3.215 NCU04089.1 (version3)
Neurospora crassa sequence contig 1.145 (supercontig 19)
18532 MITDLIIKVLAQHWPAILCLVLVGWLVRNRYHNGLNKYPGPFLASLTDWWRFID (0)
KHGPIVRLGPNTLSFSDPEAIKTIYGLNKGFVK (0)
SDFYVVQQSTVKGHNLPSLFSTTDNEFHMQFRRCVNSAFAMSALVQYEPFVDNTTK 19077
19078 LFLEQTEKLYVEGGEKACDFTRWLQFYAFDVIGEITYSKRHGFIEHNKDIDGIVS 19242
YLTKLFNYVAP (0) this joint not well supported
IGQIPLLDRLFLKNPLYLKLSQWGLIDGTMPVAAFARARMAERLPELQTEKTAILPTSEKQAQLKIQTP
19548 DLLSKFLAARSARPNFMTDTLVQTMAVSMA
FAGSETTAISLSAVFYYLLRTPRALARLREEIDEAARQGKFSDYETG 19778
19779 LVTWAEAQTLPYLDACVKEAFRLHPAPGLPMERVVPPQGMEIVPGQFVKGGTIVGVSAWV 19958
19959 LHRDESIFGERVEEFRPERWFVDETVAKEDMEGKKREEEEKRIKTMNGHMLQFGMGSRTC 20138
20139 IGKNISLLEIYKLVPTLLRRFEVSLPPSLFFPPFLSYWIWRETID*
CYP532A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_60876
95% to CYP532A1 N. crassa
See fungal pages for seq
CYP532A2 Magnaporthe grisea
MG07795.4 65% to CYP532A1
AACU01000949 cont2.1444
See fungal pages for seq
CYP532A3 Fusarium graminearum
FG01745.1 AACM01000092 FGcontig1.92_scaffold1
See fungal pages for seq
CYP532A4 Aspergillus nidulans
AN2125.1
56% to 532A3 top part
revised 7/18/07
MALVTEILDHTEPLSNYGLYILPFFILLYLAQQYFHNGLHRYHGPILAKF
TNLWRFLDVRGRRPELTHIALHRKYGDVVRLGPNTLSFASPSAIKVIYGL
NKGFTKANKSQSEFYPVQMTVSKGEPLPSLFSTLDESFHANLRRSVNHAF
SMSSLVQYEPMVNQTVELFLDQTAALFANSGKTCDFARWLQFFAFDVIGS
ITYSKRHGFIEKNEDIDGILKSLARIFDYAGPVGQMPWLDKWLWKNPIYD
VLQRWGIADNSHPVAIFARQRMNERLMADNGTRTEAEQQQDLLTKFIQAG
KDRKDFMTEKRVLTMAVSMAFAGSETTAISLAAVFYYLLKNPEYMARLRG
ELDNAVAHGIVENRSSGLVTWSESQKLPFLDACIKEAFRIHPAAGLSLER
VVPASGIDIAGHFIPGGTIVGCSAWVLHRREEIFGPDVDSFIPDRWLNVS
AERLKTMNGTMLQFGAGARTCIGKNISLMEIYKLVPSFLRRFDIQLAHAD
QEWELWNAWFVRQYNFKTKFTARNFEV
CYP532A5 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_1001305 NEW
Necha1/scaffold_1:4090277-4092053
83% to CYP532A3 probable ortholog
See fungal pages for seq
CYP532A6 Aspergillus oryzae
GenEMBL BAE66552.1
74% to 532A4
MTLLAEVFSRASPEYALYILPFISLIYIGHLYFHNGLNRYPGPFLAKFTDLWRFLDVWGRQPHETHIALH
RKHGDVVRIGPNTLSFSSPAATKVIYGLNKGFTKSEFYPVQMTVSKGEPLPSLFSTLDDKFHAELRRSVN
HAFSMSSLVQYEPMVDETTLLFLDQTDRLFATGGKVCDFARWLQFFAFDVIGSITYSKRHGFIEKNEDID
GIVKSLARIFNYAGPVGQMPWLDKVFWKNPIFDAMQKWGLLDNSHPVAIFARQRMMERMSSKAAIDPSSR
SDLLTKFMKAGELRPNFMTEKRVLTMAVSMAFAGSETTAISLAAVFYYLLKTPDYMRRVREELDEAIQNG
TIENRPSGLVSWTESQKLPFLDACIKEAFRIFPAAGLPLERVTPPSGADIAGQFIPGGTIVGCSPWVIHR
REDIFGSDVDTYNPDRWLNASEDKLKIMNGMMLQFGAGSRTCIGKNISLMEIYKLIPSFLRRFDVRLAYP
EQEWRLWNAWFVRQYNFNTVFTPRKIEVQ
CYP532A6 Aspergillus flavus
100% to CYP532A6 Aspergillus oryzae
See fungal pages for seq
CYP532A7 Mycosphaerella graminicola
55% to CYP532A2 Magnaporthe grisea
See fungal pages for seq
CYP532A8 Fusarium oxysporum
85% to CYP532A3
See fungal pages for seq
CYP532A8 Fusarium verticillioides
98% to CYP532A8 Fusarium oxysporum
See fungal pages for seq
CYP532A9 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_1001379
70% to CYP532A7 Mycosphaerella graminicola
CYP532A10 Grosmannia clavigera
CYP532B1X Fusarium graminearum
renamed CYP5080A1
CYP532B2X Fusarium graminearum
renamed CYP5080A4
CYP532B3X Nectria haematococca (Fusarium solani group)
52% to CYP5080A4 possible ortholog
renamed CYP5080A5
CYP532B4X Nectria haematococca (Fusarium solani group)
75% to CYP5080A1 probable ortholog
renamed CYP5080A2
CYP532B5X Nectria haematococca (Fusarium solani group)
54% to CYP5080A1, 59% to 5080A2
renamed CYP5080A3
CYP532B6X Nectria haematococca (Fusarium solani group)
50% to CYP5080A1
renamed CYP5080A6
CYP532C1X Fusarium graminearum
Renamed CYP5078A2
CYP532C2X Aspergillus nidulans
Renamed CYP5078A3
CYP532C3X Nectria haematococca (Fusarium solani group)
57% to CYP5078A2 probable ortholog
Renamed CYP5078A1
CYP532D1X Aspergillus nidulans
renamed CYP5080D1
CYP532E1X Aspergillus nidulans revised
GenEMBL AACD01000108.1
renamed CYP5077A1
CYP532F1X Aspergillus nidulans
renamed CYP5080B1
CYP532F2X Aspergillus oryzae = CYP5080B2
GenEMBL AP007164.1f
sixth P450 of six on this accession
CDS join(1717617..1717983,1718066..1718266,1718322..1719073,
1719123..1719320)
52% to CYP5080A2
72% to CYP5080B2
renamed CYP5080B2
CYP532G1X Nectria haematococca (Fusarium solani group)
44% to CYP5080A4, 62% to 5080C2
genome annotation in progress
renamed CYP5080C1
CYP532G2X Nectria haematococca (Fusarium solani group)
62% to CYP5080C1
renamed CYP5080C2
CYP532H1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_58000031
Necha1/scaffold_58:68174-69912
46% to 532A2, 55% to 532H2
two small deletions compared to 532A2
These deletions are not seen in AP007175.1 Aspergillus oryzae
See fungal pages for seq
CYP532H2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.12.581.1
Necha1/scaffold_12:138036-139715
55% to CYP532H1
See fungal pages for seq
CYP532H3 Fusarium oxysporum
81% to CYP532H1
See fungal pages for seq
CYP532H3P Fusarium verticillioides
90% to CYP532H3 Fusarium oxysporum
no gene model, missing C-term
See fungal pages for seq
CYP532H4 Fusarium oxysporum
60% to CYP532H1 Nectria haematococca
AAXH01001105
See fungal pages for seq
CYP532H4 Fusarium verticillioides
97% to CYP532H4 Fusarium oxysporum
AAIM02000185.1
See fungal pages for seq
CYP532J1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_24000107
Necha1/scaffold_24:254874-256710
47% to CYP532H1
See fungal pages for seq
CYP532J2 Aspergillus niger
JGI gene model e_gw1.2.1446.1|Aspni1
63% to CYP532J1
See fungal pages for seq
CYP532J3 Aspergillus terreus
72% to CYP532J2 Aspergillus niger
See fungal pages for seq
CYP532K1 Mycosphaerella graminicola
45% to CYP532J1 Nectria haematococca (yellow part omitted)
42% to 532A6, 45% TO 5077A1
Families CYP532 and CYP5077 overlap,
cyan from JGI model e_gw1.12.214.1|Mycgr3
See fungal pages for seq
CYP533A1 Neurospora crassa
AABX01000277.1, 42-43kb region
Neurospora crassa sequence contig 1.246 (supercontig 26)
9a3.tfa_80cg@9A3 AL353820.2
N-terminal of this seq is probably incorrect
since C-helix WGLHRK starts at aa79
MFRRMSPSGKYLEWSKKYNSDVLYFETFGTKWVVLNSYEAAHELLEKRGRKYSDRPRFVMFEEMGWAPTLTWLRW
GPQWGLHRKVLAPPFAKTGCVSFQPLQRKQAMIMCKNLIENPEEWMSAVTHFAVAIMFKIGYGIDVDTPTDEWVK
LAAEASEAVGKAGAPASSIMDRIPWTRHLPDWLPFMERLKYAHENKKVIQNITERPFNASMSDYHERDLDPTRKL
KECFVHRMYHLRGEDARRNRQNVYYEEDIKGGAATMLIAGNDTTASTLNLIILYLTKHPRVQRRAQAEVDYILLT
TGVPTEPVEDYRPSTPAPWASSSSNRAGIIRLPTLEDIPKFKYVNLILQEVYRINPLSPLGIPHASVKDSSDIDP
DGDDTYNGMRIPCGTIVYPNVWAMNRDEKRYREPERFFPERYLPKEEGGWGEPLPVGNFGFGRRVCVGQYLAENS
LLIAIAMMLATIEFDLPIGPDGNLKDFEPQFSHKGQSIVLPFKVSIKPRSPMVEELLDRHILVAKMAEKAAEDGK
KGGPTPSA
CYP533A1 Neurospora discreta
JGI gene model fgenesh3_pm.C_scaffold_14000109
90% to CYP533A1 N. crassa
See fungal pages for seq
CYP533B1 Magnaporthe grisea
AACU02000566.1 revised
See fungal pages for seq
CYP533C1 Grosmannia clavigera
CYP534A1 Neurospora crassa
AABX01000272.1 cont3.221 NCU04234.1 (version3)
Neurospora crassa sequence contig 1.285 (supercontig 30)
9a12.tfa_40cg@9A12 2 aa diffs with
9a22.tfa same gene missing first 326 aa
run of SSSSSSSS may be in an intron
MRLTPLVTLLGVFLAWATYKIYAGFRSNIAKARKTGYPVLITPIYPLSPLWLTTRHFLLPILTRLLPERLYASYV
FVMTPDWEYHPSPRSHFTRLGSDTFVVASWNGLACYTSDAAVISQVMSRREAFPKDTRQYGILEIFGSNVVTTEG
QVWRMHRKVTSASFNERNAGHTFREAVRQTRGMVGGWFSSSSSSSSSSSSSGSQEEGTGRREGDVEDMTGIITTL
EHDTMRWALNIIGYVGFGLKLLWPHESMPKDMDPKLAKYGSLQPPYGYSMTFADSLATVLERIVILLLIPSAVLK
RIPERWGSWGSKLHEAWEAKVNYSKYMNAFLAEKVQDIRAGVQEREGMNIMGQLVRSKYDPSSSEKNDGATMKLE
DSEIMGNAFIMTLAGHETTANVIHFAIVELAMHPEVQRRVQRDIDAIFGRDSDPETWDYEKSINALLASYIGAVI
NETLRLIPPVVVTPKRVADTDQWVQDGGQRHPMPAMMPVMPVISAVQRSRRYWPALHDKTTKKGDTDDLDEWHPD
RWYLPSMSQGQPSSDGEKGEGKQQQEENYGGYQGTDTSPTLFRPVRGSFIPFSDGARSCLGRRIAMVEMVAAIAV
LFQKYSVELAVDASDEEVQMMVPEQRRHVHAKAQEKAKETV
Probable break between P450 above and other seq that CONTAINS a MATCH TO
ELONGATION FACTOR 2 KINASE AND IS PROBABLY AN INCORRECT ASSEMBLY FUSING THE P450
TO THIS GENE.
CYP534A1 Neurospora discreta
JGI gene model fgenesh3_pm.C_scaffold_1000944
90% to CYP534A1 N. crassa
See fungal pages for seq
CYP534B1 Magnaporthe grisea
MG06872.4
old name = CYP588A1 44% to CYP534A1 AACU01000608 cont2.1276
See fungal pages for seq
CYP534C1 Fusarium graminearum
FG09916.1 AACM01000411
old name = 588B1 FGcontig1.411_scaffold7
See fungal pages for seq
CYP534C2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.6.655.1
Necha1/scaffold_6:586178-588240
71% to 534C1 (probable ortholog)
Note: the region between PERW and heme motifs
is about 40 aa longer than usual
and the C-terminal tail after the heme is about 40 aa longer than usual
See fungal pages for seq
CYP534C3P Fusarium oxysporum
60% to CYP534C1 Fusarium graminearum & = frameshift
See fungal pages for seq
CYP534C3P Fusarium verticillioides
61% to CYP534C3P Fusarium oxysporum
See fungal pages for seq
CYP534D1 Mycosphaerella graminicola
39% to CYP534C1, 41% to 534A1, 41% to 534C2
See fungal pages for seq
CYP534D2 Mycosphaerella fijiensis
JGI gene model e_gw1.8.61.1
67% to CYP534D1 Mycosphaerella graminicola
See fungal pages for seq
CYP534E1 Metarhizium anisopliae var. acridum Ma102
CYP534E1 Metarhizium anisopliae var. anisopliae Ma23
CYP534F1 Grosmannia clavigera
CYP535A1 Neurospora crassa
AABX01000066.1 cont3.39 NCU00987.1 (version3)
Neurospora crassa sequence contig 1.294 (supercontig 32)
MGAATLIYEARWLLASVVLAIWAVLKTKQYYRLRHFKGPFGTGWFEIWHGLAYLSGHPHLKFKEATDKYG (1)
PIARIGPNELMTTSLELLAHINGARNRYTRTRWFYIAARFQPNSDNILSELDDNMHTKRRAQMAGG (0)
YSGKENRELESSVDIHVAELVQLIRTKYRSTEIKTNPFDLAQKAQYLALDVISHIGFG
EPFGMLLSDQDVNGYIKHADQGMNAITYLWGLGLTELVLDTPLMHLLGPSDTAKTGFGA
MTANTRKIISKRLEDDPGMTKGSDMLASWFRHGLDKEQLVTESILQLLAGAETAATSMRC
IMLYLVTNPRVYAKLQAEVDAAVKDGRAPPYPSVVSNATQRQLPYLWACCKEGMRMHPPV
TNSSQKKVPPEGDAVTVEGKTVYLPGGTNIGYCVWGLNRDQKIFGGDADCYRPERWLNEE
DPKKLAQMNLVHEMLFSYGKFQCLGKPIALMEIGKAIF (0)
LMRNFDWSVTNAAEPWKEMNAGALFLTHDFLVEATERSVS*
CYP535A1 Neurospora discreta
JGI gene model e_gw1.4.292.1, fgenesh3_pm.C_scaffold_4000422
86% to CYP535A1 N. crassa, missing C-term, added below
See fungal pages for seq
CYP535B1 Magnaporthe grisea
old name = CYP571B1 Magnaporthe grisea MG04404.4
41% to 527C1 45% to 535A1
AACU01001103 cont2.830
See fungal pages for seq
CYP535C1 Magnaporthe grisea
old name = CYP571A1 Magnaporthe grisea MG08500.4
42% to 535A1 cyan too long AACU01001266 cont2.1600
See fungal pages for seq
CYP535D1 Aspergillus nidulans
AN9296.1 40% to 527C1 N-term does not match
See fungal pages for seq
CYP535D2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.4.832.1
Necha1/scaffold_4:327672-329378
57% to 535D1 Aspergillus nidulans,
47% to 535C1, 44% to 535A1, 41% to 570C2
See fungal pages for seq
CYP535D3P Fusarium oxysporum
seq. runs off the end of the contig
75% to CYP535D2
See fungal pages for seq
CYP535D4 Metarhizium anisopliae var. acridum Ma102
CYP535D4 Metarhizium anisopliae var. anisopliae Ma23
CYP535E1 Aspergillus oryzae
GenEMBL BAE61757.1
46% to 535D1, 49% to 535C1 Mg, 47% to 535A1
52% to 535D2, 44% to 535B1 Mg
revised 3/18/2009
MGLVELVLETRWLIVGSLFILYFLKKFQAYYRLRKFKGPLSCGFSHFLHTKAVLSLRCERWYKEMTDQYG
SIVRIGPNALITSSPELWAHINAVRSPYKRSDWYYHAARFKPGEDHVFSETNNERHDRRRKQMLMGYSGK
ENLSLESDIDLRVLDFLDLIRNRYLSTEDCLKPMDLAKKVQYLTLDVISTVGLGNSFGMLKADKDVNDYI
KSGEEGLWVSNFLMGTGLHWIMQIEWVGRLLGPSTDDLKGFGKMMATTGQMVAKRLQSPTNARSDMLASF
IRHGLIGNELWMEAFEQVLAGSDTTASGIRGILLCLLSNPRVYKKLQAEIDGAVQDGRAPSTGIISDAQL
RRLEYLQAVIREGLRIFVPVVNIFARDVPPEGDEVIVDGESVQIPGGTWIGYSALGMHLNKATYGEDAEV
FRPERWLIDDKDHLANMTRVNDLIFGYGRWKCLGQTVALIEIGKTIFE
ALRNFDWALANPEQPWRRKNVNGLFAVSDMWVTVTAREQLGSCL*
CYP535E1 Aspergillus flavus
99% to CYP535E1 Aspergillus oryzae
See fungal pages for seq
CYP536A1 Neurospora crassa
AABX01000239.1 cont3.377 NCU06526.1 (version3)
Neurospora crassa sequence contig 1.402 (supercontig 52)
MGVVLKVKDGKVSPTRVLVGATATVLASYWLYILLFAIVIRAASKRYASPLRKYPGPFLASCSRLWKVL
STASGRTHLDHIELHRKYGPVVRIAPNEVSVASPEAARTLLSAGKRFFKTPFY
SVFPPAENPDIFTEIREDAHAQKKRVANVPYSMAAMQQLSPFIDDTIELLVRKIDEHI
AQHKGVFDLGDYLHYFAFDVLGEVAFSRSFGFLAQGRDVDNAIKTIDKSQTY
NGIVGQVPELDHLLRRNPLWRSIPWLSTKNALITRMALEEMGRRQPFNKD
TAVLQTGDTRQDLMASLILGHLKSPEKFGVGDVFAVAHGAI (2)
FAGSDSTASTMQSFFYHVLSSPSTYQSILYEIQSAVATGVIPATGNLTWNEAQTLPYLQAC
LKEAMRLRPAVGLNITRFVPPEGAELDGHFFPGGTSIAVNGWVLHRDKLTFGNDADEW
RPERWLENEEEARRMERYMFQ (0)
FGGGSHLCIGRNLALLEINKVVPRLLRDYRFELAHPGRELKATASFFVVQSGLEVFVRRA*
CYP536A1 Neurospora discreta
JGI gene model estExt_fgenesh3_pm.C_30692 [Neudi1:154377]
94% to CYP536A1 N. crassa
See fungal pages for seq
CYP536A2 Magnaporthe grisea
MG05235.4 70% to CYP536A1 AACU01000803 cont2.971
See fungal pages for seq
CYP536A3 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_32000050
Necha1/scaffold_32:150926-152616
52% to CYP536A1
See fungal pages for seq
CYP536A4 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1Plus.C_11313
58% to CYP536A2 Magnaporthe grisea
See fungal pages for seq
CYP537A1 Neurospora crassa
GenEMBL AABX01000723.1 AABX01000717.1
Neurospora crassa sequence contig 1.443 (supercontig 59) C-term
Neurospora crassa sequence contig 1.444 (supercontig 59) N-term
57% to CYP537A4
521086 MTLLLLLPIIIFLLHNLIYKPLTSPLSSLPGPLYTKFTSLVLK
YHELRANRTRWIHALHVRYGPVVRIAPNEVSFASREGVKEIYC
SGGSGFDKSGWYDLFKIYGRR (2) 521406
521667 TMFTFLKKDD (0) 521696
521762 HAKRKRILADRYANSNVMRQAPLSGIIERADR
VVKRCAESLDGSLDLY (0)
AVHSYAYDCSIRTTCFHPYGTDXLRN
QQDEEIMREITFDDSLQ (1)
97 NRQLSYYSPTLHKAISKILYICGIK
PRETPLADKFILDTAAKTDAAPFTLLDRLH (1)
NSKIAQ
IDQLDIAAELLDHMVAGIDTTGDALCFLMWELSQPRSRQIQTKL
REELLSHPSSDINFDKLPYLDAVVMEGLRCFPAIPMSLPRIVPR
GGKTIDGYFLPEGTTASCQAYSMHRIDMEAWGPDPDAFRPERWF
EEKGDAARKKLFFAFANGARGCIGKH (2) 801
907 LALAEMKILLREVYSKFTTVPDKTMTEE
DMEMEDQLISTRPAGLKCLLKFEPIGGQ* 1077
CYP537A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_50619,
possible gc boundary after NRLH
91% to CYP537A1 N. crassa
See fungal pages for seq
CYP537A2 Fusarium graminearum
FG05426.1 AACM01000224 FGcontig1.224_scaffold3
See fungal pages for seq
CYP537A3 Magnaporthe grisea
AACU02000684.1 revised 2X
AACU01001722 58% TO 537A1
See fungal pages for seq
CYP537A4 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.9.142.1
Necha1/scaffold_9:176128-177897
79% to CYP537A2 probable ortholog
See fungal pages for seq
CYP537A5 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.10.477.1
Necha1/scaffold_10:12960-14643
58% to CYP537A2
See fungal pages for seq
CYP537A6 Fusarium oxysporum
87% to CYP537A4
See fungal pages for seq
CYP537A6 Fusarium verticillioides
96% to CYP537A6 Fusarium oxysporum ortholog
See fungal pages for seq
CYP537A7 Metarhizium anisopliae var. acridum Ma102
CYP537A7 Metarhizium anisopliae var. anisopliae Ma23
CYP537A8 Grosmannia clavigera
CYP537B1 Aspergillus nidulans
AN8905.1
45% to 537A2 53 clan
revised 7/19/07
MLTFYLAASIIVTVLFMRRLCSPIAKLPGPWYATFTSWVLKYHEFTSNRR
LFIHDLHKKYGSTVRIAPNEISFASLEAIKEIYGSGGSGYDKTELYDLFRQFGIK
TMFST
LDKHSHSQRKRELADRYAMSNILREEHVSAIVDRARAVVSRCAASAESVD
VYVWLHCYALDGVTNFMFSPGGLHSLDSEHDFKIMEELTYHQSLQKNLLH
YYLPTVAAYFPPCLTPRRSPKTNEYVLKMCAQQLPSQHSLVAKLARKDSP
LNHTQVAAECKDHMAAGIDTTGDGLCFLMWKLSQPHNIRFQERLWEELRT
ARPDIPLDKLPYLDAVVKEGLRCAPPIPMSFPRYVPTGGRSIDGHFVPEK
TIVSCQPYTVHRLDENVFPEPDSFNPDRWMVEKGAVERNRLFFAFSTGGR
GCTGRNLALVEMKILLREVYSRFRTTVAKDMHGCMDIDDQIISSRPLGQT
CKLRFSET*
CYP537B2 Aspergillus oryzae
GenEMBL BAE66494.1
67% to 537B1
note: retains small intron due to lost phase 0 boundary
MWSLWLSSILLVGLYLFKRLSSPLAKVPGPWYTNLTSFCLKYHEFTATRRLFVHRLHKKYGPVVRLAPNE
VSFASLDAIREIYASGGSGYDKTEYYDLFRQYGIN (2)
TMFSTLEKQE
ISAYITIEAIATNDVQ
HSHRKRELADRYAMSNIVRDKHVSAIKERAQAFVSRCAAIEGSVNVY
SLLHCYALDGVTNFMFSPGGLKSLDNTKDYEMMEELTYHQSLQKNLLYYYLPRLAPYFPSCLHPRPAPR
ANAYVLQMAGQQHPEAHSLVARLTRKGSPLSHMQVAAECKDHMAAGIDTTGDALCFLMWELSQPQNLQFQ
DRLHKELLSTSDDTPLDKMSYLDAVIKEALRCAPPIPMSIPRYVPSGGRTIDGYFIPENTIVSCQPYTVH
RFNEEVFPEPDRFNPERWLEEKGFNDRNRLFFAFGTGGRGCTGKNLAMVEMKILLRELYSRFRSSVAPDM
TASMDLDDQIISARPKDQICKLNFAVRGDDVDTA
CYP537B2 Aspergillus flavus
98% to CYP537B2 Aspergillus oryzae
See fungal pages for seq
CYP537B2 Neosartorya fischeri
100% to CYP537B2 Aspergillus flavus
seq runs off the contig end
See fungal pages for seq
CYP537B3 Aspergillus niger
JGI gene model e_gw1.14.367.1|Aspni1
71% to CYP537B1
See fungal pages for seq
CYP537B4 Aspergillus terreus
73% to CYP537B2 Aspergillus flavus
See fungal pages for seq
CYP537C1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.38.28.1
Necha1/scaffold_38:43917-45683
43% to 537A3 Magnaporthe g. 42% to 537B1
See fungal pages for seq
CYP537D1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.23.292.1
Necha1/scaffold_23:445038-446732
43% to CYP537B1
See fungal pages for seq
CYP537D2 Fusarium oxysporum
78% to CYP537D1 Nectria haematococca
See fungal pages for seq
CYP537D2 Fusarium verticillioides
94% to CYP537D2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP537D3 Grosmannia clavigera
CYP537E1 Grosmannia clavigera
CYP537F1v1 Postia placenta (brown rot basidiomycete fungi)
CYP537F1v2 Postia placenta (brown rot basidiomycete fungi)
CYP537F2 Postia placenta (brown rot basidiomycete fungi)
CYP537G1 confidential basidiomycete
CYP538A1 Neurospora crassa
AABX01000024.1 cont3.89 NCU02031.1 (version3)
Neurospora crassa sequence contig 1.498 (supercontig 67)
b2j23.tfa_120cg@B2J23
42% to Yarrowia CYP52F1 40% to 52A2 34-39% to other CYP52s
MLTPTTLLLLSPLLYLLTLLFRTALYRLRARSLGCSPVAVYPHKDPILGLDLFRESLRAMNTHALLPLWDARFKR
YGNTHYTLTLGKWVLMTNEPENVKVILGTKMAEWPIDGPRLHASVAVLGKKSIFTTNGAQW (?)
REARGMIRPSFVRD
QVADLHCFAKHVGNFLNAIPKDGSTFDMQELLLSMTMDSSTDFLLGCSTNSLLQPSPEAKQFLEDFEYTSREAAK
KSRLGTLLNWLPNGEFQATVTRVREYVRAYIRKSQAEKTDKKERDYVFLHEILKSGADEEHAIDQVLSVIIAGRD
TTAAAMTACFYYLARNPEAVKKLRKEIFDMEDEMPTWEQLKNMKYLNMIIKEG (?)
LRLFPPASTNSRAPIKDTVLPRGGGPDGKQPILVPKGQVVRWSLYSLHRRKDIWGEDAHEFRPERWDENLRVG (?)
WEYIPFSGGPRICLGQQFALTQIEYALFKFFRAFKSIEPRDDNGPLLLRTNLTVTFAKGCLVSATPDSN
CYP538A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_20706
93% to CYP538A1 N. crassa
See fungal pages for seq
CYP538A2 Magnaporthe grisea
MG02792.4 54% to CYP538A1 AACU01001559 cont2.569
See fungal pages for seq
CYP538A3 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_1000354
Necha1/scaffold_1:1132876-1134514
49% to CYP538A1
See fungal pages for seq
CYP539A1 Neurospora crassa
AABX01000502.1 cont3.571 NCU09115.1 (version3)
Neurospora crassa sequence contig 1.664 (supercontig 91)
seq in () may be introns most similar to CYP54A
low 40% range.
3508 MGLVEDVAGNLSLKNTPIIFGGVLLGLIVFRYLQVVWQNLRIARM
GLRPPKIRDSGLF (1) 3681
3740 GIKFIKTNVKMAAEHKNLQFWQQMFRSIGGYTGEVRLVGHRIIFT
SEPENMKAILATQFEDYGKGEGFHQEWKDFLGDSIFTTDGDLWHA
SRQLIRPQFIKNRVSDLQCFENHMQMLFRTIANGGALNGEDQMVD
MEAGNGKPVDISDLFFRYTLDAATDFLLGKDIKSLS (2) 4252
4308 TPVQPFADAFQEVQRVQIVIARAGPLNRFVPKKTFWEGLKVIDET
INFYIDRALRLDEEELASKSKGDEGYTFLHALAGFTKNRQVLHDQ
LMAVLLAGRDTTACTLS WAIYELARHPEAVAKLRAEILSVVGPDR
APTYDDLKSMKYLQNVMNETLRLYPVVPFN (2) 4782
4867 VRMALKDTTLPRGGGPDGSQPIVILKDTPVGYSPLAMQRRPDLYP
PVSEKFPDVEMFSPDRWFHWQPKPWQYIPFNGGPRICIGQQFALT
EMGYVLTRLFQRYD RVVSYMDEIDGGKPRMKTDIVLMPGDGVKVA
FFEAKRE* 5295
CYP539A1P Neurospora discreta
fgenesh2_pg.C_scaffold_7000212
91% to CYP539A1 N. crassa, added back EXXR region
See fungal pages for seq
CYP539A2 Magnaporthe grisea
MG09920.4 64% to CYP539A1 AACU01001746 cont2.1896
See fungal pages for seq
CYP539A3 Fusarium graminearum
FG01284.1 AACM01000065 FGcontig1.65_scaffold1
See fungal pages for seq
CYP539A4P Aspergillus nidulans
AN5478.2 AACD01000094
C-term only first part like CYP52
56% to 539A3 52 clan
PSEUDOGENE
This gene is not correctly annotated at BROAD.
It is a pseudogene. Some parts are missing and there are frameshifts.
It should not be fused with the next gene.
LSAKGIDCAVRAVYQLLNYNFVEWTQNVLEENGRTVELHLAGARLVLTDDCENVKAIMFS
GKGKFTHEVFASVFGDSVFGS
LNRCGTRSPPSAKALKDLVFLKYVIRETLRLY
AMQDPVAITITSALFELVRHPEIAQRLREEVVRV
VVGFNIREAQRDTTIPIGGGPNGDLLITILKGQHVAYSVIGLQRRPDIVGPDADNWRPDGY
310339 MGTFHWAPQTWEFIPFNHGPRICLGRVFGYFQMEYTLCRIFQHFERVE
LHEPRVQRIKVELNTKMAYPVN CSFHRAVY* corrected end for P450 part
CYP539A5 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_2000110
Necha1/scaffold_2:391800-393499
78% to CYP539A3 probable ortholog
genome annotation in progress
See fungal pages for seq
CYP539A6 Mycosphaerella graminicola
54% to CYP539A1 N. crassa
See fungal pages for seq
CYP539A7 Fusarium oxysporum
88% to CYP539A3
See fungal pages for seq
CYP539A7 Fusarium verticillioides
97% to CYP539A7 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP539A8P Aspergillus terreus
note: best matches are CYP539A seqs but
no I-helix motif LAGRDTT is found suggesting a probable pseudogene
C-term half is 48% to CYP539A2
CYP539J1 is 3 kb upstream
See fungal pages for seq
CYP539A9 Mycosphaerella fijiensis
64% to CYP539A6 Mycosphaerella graminicola
estExt_Genewise1.C_13960
See fungal pages for seq
CYP539A10 Metarhizium anisopliae var. acridum Ma102
CYP539A10 Metarhizium anisopliae var. anisopliae Ma23
CYP539A11 Grosmannia clavigera
CYP539B1 Magnaporthe grisea
MG06973.4 45% to CYP539A1 AACU01000620 cont2.1289
See fungal pages for seq
CYP539B2 Aspergillus nidulans
AN4858.1
53% to 539B1 49% to 539A1 52 clan
revised 7/18/07
MSQMDPKIYLLLFLSPVLAFSGLILIYILTRPIRLFLYDRRFYLKGGIHAPMIPRDIIS (1)
VTRFFFAVVKAQNEHRLYEFFKKSLEHGD
PASPNCVESNIFGSFRVIQTREPEHLKAVLTGKFADFGKGELFHKLWIPF
LGDSIFTTDGKEWQGSRNLIRPMFIKDRISDLDIFERKTQT
MLSLYSPCG
EPTDVVDLFYRMTLDAITEFLLGKGINSLENPQADFALAFADVQRIQTLL
TMLGPAQYLYPRGRYNQGLKVINDFVWPFVHDTLGFQADDLKSSDKSFTF
LHALANYTRSPKTIRDQVVSILLAGRDTTAATLSWAFYELSHYPEAYSKL
RAEILDKVGPTRAPTYDDLKNMPYLRHTINEVLRLYPAVPYNIRFALTDT
TLPIGGGVNGDLPITILKGDAVAYSTYAMQRRADLYPPVSEKFADPAIFS
PERWEVWSPKPWHYVPFNGGPRICIGQNFALAEMGYTIVRILQRYERIEY
VGDWERQFHKSEIVGTPGMGVKLRLYEARKP*
CYP539B3 Metarhizium anisopliae var. acridum Ma102
CYP539B3 Metarhizium anisopliae var. anisopliae Ma23
CYP539B4 Metarhizium anisopliae var. acridum Ma102
CYP539B4 Metarhizium anisopliae var. anisopliae Ma23
CYP539B5 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-5
59% TO CYP539B1 Magnaporthe grisea, 56% TO CYP539B2 Aspergillus nidulans
CYP539C1 Magnaporthe grisea
MG08234.a 42% to 539A1 top half AACU01000307 cont2.1540
2 P450s fused
See fungal pages for seq
CYP539D1 Aspergillus nidulans
AN3917.1 52 clan 53% to 539A1
See fungal pages for seq
CYP539D2 Aspergillus fumigatus Af293
GenEMBL XP_750735.1 also EAL88697.1
71% to 539D1
MIEELLAQIHSGWAALYVLGALFFACLIRKAQVSMEISKLGYRAPRIRFYLPWAIDFLYEASKANEDGTD
HVFLHQAILNAKGATQLDCVKTAELNGGITRRVILTKDPENIKAILTGQFADYGKGEEFHEQWKDFLGDS
IFATDGELWSRSRHLIRPMFVRDRIVDTEIFEKHVQNLIPLLEGSNSPSGSKAVDVGSLFFRFTLDAATD
YLLGQGTNSLHNPETRFAEAFGYVKHRQSEIFRLGDGISMFSFIVAKRKFRRELKVMDDFFQPYIKRALS
LTPSELDQKISKRETFLDALARFTRDPRVLRDQIVAVLLAGRDTTAAVLTFCIFELARNPDVVAKLREEI
SARLGLGPSAQKSSYNDLKEMKYLNAVLNETMRLYPPVPFNVRYSLRDTTLPRGGGPDGLSPVGVRANTR
VIYSTMIMQRSAENYDPPGSPNYFDPEKWLPDRWLSGWQPKPWQYIPFNGGPRICLGQQFATIEMGYTVV
RILQAFERIHAMPANGKERVEDPVLKFEVTLSPGSELNCVFVREGEDTLPLKDG
CYP539D3 Aspergillus niger
JGI gene model e_gw1.4.261.1|Aspni1
67% to CYP539D1
See fungal pages for seq
CYP539D4 Uncinocarpus reesii
57% to CYP539D3
See fungal pages for seq
CYP539D5 Coccidioides immitis
85% to CYP539D4 Uncinocarpus reesii
See fungal pages for seq
CYP539D6P Histoplasma capsulatum G217B
pseudogene
68% to CYP539D4 Uncinocarpus reesii
Second half of this model is like annexin (deleted)
ABBT01000091.1 Ajellomyces capsulatus G217B 86855-88176
See fungal pages for seq
CYP539D6P Histoplasma capsulatum G186AR
Supercontig 8: 874979-876322 +
88% to CYP539D6P Histoplasma capsulatum G217B
See fungal pages for seq
CYP539D7 Aspergillus clavatus
68% to CYP539D3, one frameshift = &
See fungal pages for seq
CYP539D8 Aspergillus fumigatus
supercontig 6 1986238-1987987 (+) strand
See fungal pages for seq
CYP539D8 Neosartorya fischeri
95% to CYP539D8 Aspergillus fumigatus = ortholog,
79% to CYP539D7
See fungal pages for seq
CYP539D9 Aspergillus flavus
75% to CYP539D7 Aspergillus clavatus
See fungal pages for seq
CYP539D9 Aspergillus oryzae
Supercontig 5: 1308953-1309825 (+) strand
100% to CYP539D9 Aspergillus flavus
See fungal pages for seq
CYP539D10 Aspergillus terreus
76% to CYP539D9
See fungal pages for seq
CYP539E1 Fusarium graminearum
FG08005.1 AACM01000323 FGcontig1.323_scaffold5
See fungal pages for seq
CYP539F1 Aspergillus fumigatus Af293
GenEMBL XP_747469.1
51% to 539B2, 50% to 539A3, 39% to 539C1,
43% to 539D1, 39% to 539E1
probably needs some revision
MQGNQMTTTTTTILDYLLLLSLSSYLLKTILGNLSSLKEGFTSLWALKIIGCLFLTIVARPIWNILFSSH
TPRDSKLPQIRTFLPLGIDYITRGIIYSAQNKSLVFWEELFRKYHPFQTLEVRLGPQTVIVSRDPQVVKA
LLTTQFGDFGKGERFHTEWREFLGDAIFTTDGDKWHASRALIRPMFTPDRVSNLSTFERHVQKLLRILES
PRHERQPVNVLDLCLRLTMDIATDFLLGQSVDSLSNPTHRFSAAFADVQRIQSWITMAGPLQVFLPKAKY
YEGLKTINSFVDPFITRTLALGRRSFEEMEGSEEEYNFLEGLATFTQDPKVIRDQLISVLLAARDTTAAT
LARTLYELSGHPDVVQRLREEILAQVGTASAPTYADLKNMRYLQAIHKETLRLYPAIPFNMRVALSDTTL
PSGGGPSGTQPVHVKKDTIVAYSPLYMHRSDLYPDAYADGTPFSDPREYHPHRWMYPGSKTADSEKINEG
PWIPKPWTYIPFNGGPRICLGQQFALAEMGYTLVRIFQKYKCLERRMRAEDGGLMRANIVLTPAQEVNVV
FIQSLSTSGAVMLILYRLRS
CYP539G1 Chaetomium globosum CBS 148.51
NZ_AAFU01000716 partial seq 50% to 539B1
MLQFLINLGLLHTSALVLG
CLSIFFLSRKLLVDYKIRKLGGVRAPVLATNPVT (1)
GLRFFLWAGYAQTKNRLDHFYRDIFNWATPECPNCVEISFL
GRTRFLMTREPEHIKTILTTKFREYGKGEQFHEAWSPFLGDSIFTT
DGQKWSESRALIRPMFIKDRVRDLEIFDKWA
TTLISKLPASGQTVDVMDLFYRMTLDVTTDFLLGGSVDSLNK (2)
PKHEFVSAFQDVQRIQMLLTIMAYATLIL
PTSPFRALIPTHRYTRGIRTLERFISPFIERTLSLPPSELDPTTNTTTTTTPNKTTTFLH
HLALRARSPQAIP*KIMGGLIAGQPTTAATLTW
CYP539H1 Fusarium verticillioides
50% to CYP539F1 Aspergillus fumigatus,
not found in the F. oxysporum genome
See fungal pages for seq
CYP539J1 Aspergillus terreus
48% to CYP539A6 Mycosphaerella graminicola
See fungal pages for seq
CYP540A1 Neurospora crassa
AABX01000009.1 cont3.484 NCU08062.1 (version3)
Neurospora crassa sequence contig 1.764 (supercontig 106)
64591 FRKYGHVIKTTNMGRTNYLTDDPAVALVALAESAYFTKKITEEHPLFGIKDNSAIFIGD 64415
64414 TETENWRLAH
64384 KFLPPAMGPKAVRHYTPLMQECVRGSFKIFDELDSRGESWNVYQYMVKLASQTVGKFAMG 64205
YHHFDAVDTPVHSLVT (?)
YQQLPFGDPARL 64061
64060 REIRQITYGQLAETIEAAPKSGIENLPLNEAATKASCVADYLLNAVDEKGEHFPKGLILS 63881
63880 NMLVVTGAGYTTTSALLSWCIYCIVTYPKMQDRLLQELIDHGINSETDWDPDLAHS 63713
63712 LPFLDAFLKETQRLHNASFQPGRTTKTDVVLPGGFRLPENVIMIPALYAIHTNPEHWHD 63536
63535 PFRFDPDRWDTEEVKSRHRGAYMPFATGPRSCIGFNFALLE 63413
63412 IKVLLSELVYRYKFAREGFEAIEYDPEFQL 63323
63322 IRPLNLYVTAKRR 63284
CYP540A1 Neurospora discreta
JGI gene model estExt_fgenesh3_pm.C_20016
96% to CYP540A1 N. crassa
See fungal pages for seq
CYP540A2 Aspergillus nidulans
AN8919.1 68% to 540A1 check introns 505 clan
See fungal pages for seq
CYP540A3 Aspergillus oryzae
GenEMBL BAE57130.1
84% to 540A2, 56% TO 540B9
MKCQFYLVGDDIATAQSILVDSRWKFEDLQRAVGGIFHVALPTGISFHTSENETLSSVADIISASSSPIG
LRIDGNAVQTPQGPKGLPLVGSFYEIFPDHLGNHYRLFRKYGPVIKTTNMGKTTYLTDDPQVASVCLAES
AYMTKKINENHPLWGVKDNTAIFIGDTETENWRLAHKYLPPAMGPKAVRHYTGLMQNCARKSLPVFDELD
GRDESWNVYQYMVKLASQTIGSFSLGKDFGHFDSVDSPLHPIVTNIANLLSLNKKITARGEWYRYLPFGD
PARLRHVQHTIYTLLQEAIDEVAGSGIADAPMNEAALSASCVVDYLLHAVDDKGEHFPQGLILANMLIVT
GAGFTTTSALLSWLLYCLVTYVGTQDRLYAELVEHGIVGPSGERNQTTWTPDLAHSLPYLDKFVKETQRL
HNASFQPGRTTKTDVVLPGGYRLPPDSVIVPALYAIHTNPKTWRDPFRFDPDRWDTEEVKGRHRCAYIPF
ATGPRGCIGFNFALLEVKILLAELVSRYEFVRDGLEAIDYDPEFQLIRPLNFYVRAKRRV
CYP540A3 Aspergillus flavus
99% to CYP540A3 Aspergillus oryzae
See fungal pages for seq
CYP540A4 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_1000410|Aspni1
85% to CYP540A3
See fungal pages for seq
CYP540A5 Aspergillus terreus
87% to CYP540A4 A. niger
See fungal pages for seq
CYP540A6 Grosmannia clavigera
CYP540B1 Magnaporthe grisea
MG10724.4 52% to CYP540A1 AACU01001777 cont2.2064
See fungal pages for seq
CYP540B2 Fusarium graminearum
FG02138.1 AACM01000111 FGcontig1.111_scaffold1
See fungal pages for seq
CYP540B3 Fusarium graminearum = Gibberella zeae PH-1
FG03548.1 AACM01000159 FGcontig1.159_scaffold2
See fungal pages for seq
CYP540B4 Aspergillus nidulans
AN3861.1
67% to 540B2 505 clan
revised 7/18/07
MLNQQFYLHGETASSAKSITLDETANLDQVKHIVAAHFAIVEPNGIGFQT
ENDCLVDVSSILTAPGPIAITIDGRAVREPEGPKGLPFVGNYFEVFPDHL
GNHQRLFDTYGPIIKTNNLGRTTYQTNDPQLSAIVLAESDFFTKKINEAH
PLYPLKTPEAGVFLGDTDTKEWRDAHKFLPPALGPKAVRHYAPTMDSCVK
DAFKVFDALDETGEAWNVYQYMLKLGSQAVGKLTLGLDFEHFTSPDAPTH
EMVHAIAELLSLNKEVTSRGDWYAKLPFGAPKRLRNLKARIEEMVDESVQ
RAARGGVSDLPLQEAALQASNMVDYAIRATDNKGEKLPKSSLIWALVVAT
GAGFTTTSSLLSWLIYGLVTYPGMQDRLLQELVDHGITEDTELTADLTEN
LPFLDKYIKEMQRRHNPSYQPGRTAKVDLVLPGGYKIPKDSVVIAALHHI
HNNPSIWDNPSRFDPDRWDTDEVKQRHKASYIPFAIGPRMCIGFNFALSE
IKVFLPRLVYRYNFIREGDGPIEYDPMFQLIRPNNL
YVRAERRVKWPAKTKSSE
CYP540B5 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_13000341
Necha1/scaffold_13:983726-985420
87% to CYP540B2
See fungal pages for seq
CYP540B6 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_23000209
Necha1/scaffold_23:527402-529200
60% to CYP540B2
See fungal pages for seq
CYP540B7 Aspergillus fumigatus Af293
GenEMBL XP_753637.1 also EAL91599.1
76% to 540B4
MASQQFYLLGESISSARTISLDGINDLEGLRNLIASHFAIVEPSGIEFSRQDVSLTDLHEITSATTPVAI
TIDGHAVRNAPSPKGLPFFGNFFQIFPDHLGNHQRLFEQYGPLIKTNTLGRTVYQTNDPILSAIVFNESD
FFTKKINEAHPLYSLKTPAAGVFLGDTDTPEWRVAHKFLPPALGPKAVRHYAPTMQKTVEDACTIFDQLD
AQGEAWNVYQYMLKLGSQAVGKLTLGLDFEHFSSADAPIHEMVHLIAEVLSLNKKVTSKGDWYASLPFGD
PKRLRDTKARIEQLVEESVQKAQRGGVEDLPLQDAALRAANMVDYALRATDNKGEKLPKSSLVWALVVAT
GAGFTTTSSLLSWLIYGLVTYPGMQDRLLQELVDHGFDDTTEITADFTDQLTFLDKYIKETQRRHNPSFQ
PGRTAKLDLILPGGYKIPQDAVVIPALHHIHNNPAIWDNPARFNPDRWDTDEVKQRHKAAYIPFGTGPRM
CIGFNFALQEIKVFLPKLIYRYKFTREGDGPIEYDPMFQLIRPNNLYVRAERRVKWPYKSDA
CYP540B7 Neosartorya fischeri
96% to CYP540B7 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP540B8 Aspergillus fumigatus Af293
GenEMBL XP_748718.1 also EAL86680.1
75% to 540B7, 73% to 540B4
MSTTTTKLFHLLGEPLSTAKEIQFESTTTYGDLRHLVAAHFAIVEPSGIGFISQDSILHDVPEIAASDEI
ISITIDGKAVREIPGPKGLPVIGNFFEVYPDHLGNHQRLFEQYGPIFKTTNMGRTVYHTNDPQLSSIIFA
ETDFFTKKINAAHPLHPIKNQEAGVFLGDTDTPEWRTAHKFLPPALGPKAVRHYAPMMQETVEDAFTVFD
ALDERGEAWNVYQYMLKLGSQAVGKLVLGIDFKHFSSIDEPPHELVYRIAESLELNKKVTAWGDWYAKLP
FGDPQRLRNARGRIIEMVNESIQNAARGGIEDLPLQDAALKASNMVDYALRATDNKGEKLPKTSLMQALV
VATGAGFTTTSSLLSWLIYGLVTYPGVQERLLQELIDNGIDADTQLTADLTDRLTFLDKFIKETQRRHNP
SYQPGRTAKVDMILPGGYKLPQDSVVIGALHHLHNNPDVWSNPARFDPDRWDTEEVKNRHKTAYIPFATG
PRMCIGFNFALQEVKVFLPKLVYRYKFTRENDGHIEYDPMFQLIRPTNLYVRAERRVKWPPRSDNAVPSP
SL
CYP540B8 Neosartorya fischeri NRRL 181
DS027697 join(1677302..1677440,1677496..1678332,1678385..1679094)
73% to CYP540B4, 96% to CYP540B8 Aspergillus fumigatus = ortholog
name revised from CYP540B11
See fungal pages for seq
CYP540B9 Aspergillus oryzae
BAE62604.1
80% TO 540B10, 69% to 540B1
revised 3/20/2009
MPIRLFYLSGEPSSTAREIELESTLDYDGLRHLIAA
HFAIVEPN (1)
GIGFQSQDAILSDVAEVLANE
DSISITIDGKSVREISGPKGLPIVGNFFEIYPDHLGNHQRLFEQYGPIIKTTNMGRTVYQTNDPQL
SSIIFSETDFFTKKINEAHPLHAIKNQQAGVFLGDTDTPEWRAAHKFLPPALGPKAVRHYAPTMQQTVED
AFKVFDHFDENGEAWNVYQYMLKLGSQAVGKLVLGIDFNHFSSPDAPPHELIQIIAESLSLNKKVTARGD
WYAKLPFGDPQRLRNMRYRIFDIVDQSIQNASRNGVEDLPLQDAALKASNMIDYAVRATDNKGEKLPKTS
LIQSLVVATGAGFTTTSSLLSWLIYSLVTYPGVQDRLLQELIDNDITEDTQITADLTDRLTFMDKLIKET
QRRHNPSYQPARTAKVDMILPGGYKLPEESVVVGALHHLHNNPEVWSNPTRFDPDRWDTEEVKNRHKAAY
IPFATGPRMCIGFNFALQEVKVFLPKLVYRYKFTKENDGPIEYDPMFQLIRPNNLYVRAERRVKWPPKSE
SATTRASL
CYP540B9 Aspergillus flavus
99% to CYP540B9 Aspergillus oryzae
See fungal pages for seq
CYP540B10 Aspergillus oryzae
BAE59862.1
80% TO 540B9
revised 3/18/2009
MPIRQFYLLGEPVSSAREIEIESSLDIAGLQHLIAAHFAIVEPS (1)
GIGFQANDNTLNDIPEITSSNGPVAITIDGKE
VREPPGPKGLPIVGNFFEVYPDHLGNHQRLFEQYGPIIKTTSLGR
TTYQTNDPVLSSIVFAESDFFTKKINEAHPLYALKQPSAGVFLGDTETPEWKVAHKFLPPALGPKAVRHY
APTMQETVEDAFKVFDEFDKQGEAWNVYQYMLKLGSQAVGKLTLGLDFQHFTSPDANLHEMVNLIAELLS
LNKKVTSKGDWYAKLPFGDPQKLKQIKVRIIEMVEESIRSAERGGVVDLPLQDAALQASNMVDYAVRATD
NKGEKLPKTSLVWALTVATGAGFTTTSSLLSWLIYGLVTYPDMQERLLQELIDHDIDENTQLTADITDRL
TFLDKYIKETQRRHNPSFQPGRTAKVDLILPGGYKIPQDSVIIPALHHIHNNPELWDNPQKFNPDRWDTE
EVKNRHKAAYIPFAMGPRMCIGFNFALQEIKVFLPKLIYRYKFTREGDGHIEYDPMFQLIRPNNLYVRAE
RRVKWPPKTEN
CYP540B10 Aspergillus flavus
100% to CYP540B10 Aspergillus oryzae
80% to CYP540B7
See fungal pages for seq
CYP540B11 Neosartorya fischeri NRRL 181
DS027697 join(1677302..1677440,1677496..1678332,1678385..1679094)
73% to CYP540B4
MSTTTKLFHLLGEPISTAKEIQFESMTTYEDLRHLIAAHFAIVE
PNGIGFLSQDSILHDVPEIAASDDIISITIDGKAVREIPGPKGLPFIGNFFEVYPDHL
GNHQRLFEQYGPIFKTTNMGRTVYHTNDPQLSSIIFAETDFFTKKINAAHPLHPIKNQ
EAGVFLGDTDTPEWRTAHKFLPPALGPKAVRHYAPMMQETVEDAFNVFDALDEKEEAW
NVYQYMLKLGSQAVGKLVLGIDFKHFSSIDAPPHELVYRIAESLELNKKVTAWGDWYA
KLPFGDPQRLRNARGRIIDMVNESIQNAARGGIEDLPLQDAALKASNMVDYALRATDN
KGEKLPKTSLMQALVVATGAGFTTTSSLLSWLIYGLVTYPGVQERLLQELIDNGIDAD
TQLTADLTDRLTFMDKFIKETQRRHNPSYQPGRTAKVDMILPGGYKLPQDSVVIGALH
HLHNNPDVWSNPARFDPDRWDTEEVKNRHKTAYIPFATGPRMCIGFNFALQEVKVFLP
KLVYRYKFTRENDGHIEYDPMFQLIRPTNLYVRAERRVKWPPRSDKAAPSPSL
CYP540B12 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_3000327|Aspni1
76% to CYP540B7
See fungal pages for seq
CYP540B13 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_1000635|Aspni1
81% to CYP540B11
See fungal pages for seq
CYP540B14 Mycosphaerella graminicola
56% to 540B11, 57% to 540B4
See fungal pages for seq
CYP540B15 Fusarium oxysporum
90% to CYP540B5
See fungal pages for seq
CYP540B15 Fusarium verticillioides
99% to CYP540B15 Fusarium oxysporum = ortholog, only 3 aa diffs
See fungal pages for seq
CYP540B16 Fusarium oxysporum
92% to CYP540B3
See fungal pages for seq
CYP540B16 Fusarium verticillioides
96% to CYP540B16
See fungal pages for seq
CYP540B17 Aspergillus clavatus
85% to CYP540B7
See fungal pages for seq
CYP540B18 Trichoderma atroviride
GE290941.1
77% to CYP540B10
MAIQQFYLLGESETATTAIDIDSNLDFDGLRHLVASYFAIVEPNGVGFQFQENALQEVSDVSSAAGPVA
ISIDGHAVREVPGPKG
LPYLGNFLEIYPDHLGNHQRLFEHYGPIIKTVNMGRAVYQTNDPKIATIAFAESDFFTK &
KINEDHPLYALKTPAAGVFLG &
DTETEEWKIAHKFLPP
CYP540B19 Aspergillus terreus
83% to CYP540B12
See fungal pages for seq
CYP540B20 Metarhizium anisopliae var. acridum Ma102
CYP540B20 Metarhizium anisopliae var. anisopliae Ma23
CYP540B21 Metarhizium anisopliae var. acridum Ma102
CYP540B22 Grosmannia clavigera
CYP540C1 Magnaporthe grisea
MG11098.4 46% to CYP540A1 missing N-term
AACU01001916.1 cont2.2255 runs off end
See fungal pages for seq
CYP540C2 Magnaporthe grisea
MG09598.4 poor match 62% to part of MG11098.4
AACU01001656.1 cont2.1833
See fungal pages for seq
CYP540D1 Aspergillus nidulans
AN9218.1 46% to 540B3 505 clan
See fungal pages for seq
CYP540E1 Aspergillus clavatus
41% to CYP540D1, 42% to CYP540A3, one frameshift
potential pseudogene
See fungal pages for seq
CYP540F1 Metarhizium anisopliae var. acridum Ma102
CYP541A1 Neurospora crassa
AABX01000779.1 cont3.283 NCU05006.1 (version3)
35% to CYP505A1 (P450 part only) 37% to CYP505A2 (P450 part only)
This contig does not have a match to the reductase part of 505A2
MSTPIPRPPGIPVLGNVFDITPSNTWWSLKALAEKY (1)
GEIFQVKILGKTIVFVASAALAEEICDEQRFQKYVGGPIVEIRATVHDSLFTAF
HHEQSWGIHHRIIAPLLTPQAVSGYTDDINLCATEVIQK
WASLGDSNVLEPLVDLNLLNLEATSLTLFSQKLNCIQAGGHPV
28005 IQAMEDAVSEAIMRPTRPGLVNWLLYSSKFKKATKTLRTWAADTVKY
27864 RQENPTDKHDMLWAFMNAKDPETGKGLSESEILDEIVTMPIGSATAPCAVTATIYYLLQ 27688
27687 NPEVVTKAREELDRVIGTGPLKDEHLSQLHYIEGITRETLRLSCAAPGFNIEPIPRQN 27514
27513 KADKSPLLLQGGKYQVAHDQKLIIVLAGVNRDPAVFEDSLAFKPERMM 27370
27369 GEEFDRLPKGVKKWYGNGKRECIGKEWANNFLKIVTARLIHEIDFEVAD 27223
EGYEFRQDGWFQIRPVAFKVRVKPRVRA*
CYP541A1 Neurospora discreta
JGI gene model estExt_Genewise1.C_130023
93% to CYP541A1 N. crassa
See fungal pages for seq
CYP541A2 Trichoderma reesei QM9414
GenEMBL AAIL01000415.1
62% to CYP541A1, no introns
66598 MTTPIPKPPGVPLLGNIFDVKPGNTWDSLRKLAEKYGEIFQIKVLGQTIVFVASAALAEE 66777
66778 LCDEKRFRKYVGGPVVEIRAAVHDSLFTAYDHEPSWGVAHRIIYPKLSPEAMKLHFGEMR 66957
66958 DLATELFNTWRGLGDKNTISPLEQLNRLNLEATTYVLYGKRLNTLIGPPHPELQAMEDST 67137
67138 SEAMKRPTRPGVLNSLLYGRKFKSSIKVMRDYAADLVKYRQENPTDRQDVLAAIMNTPDP 67317
67318 ETGKKLTDSQVIDEIVTMPIGSSTAPCLLVWAIYFLLKNPETIVKAREELDRVLGDREFE 67497
67498 LEHLEQLEYVQGIVRESLRLSSAAPGFNIEPLPKEGDKSPVLLGGGKYQVAHNQAMII 67671
67672 VLHGVNRDPAVFDDPLAFKPERMVGEAFENLPAAAKKWFGNGKRVCIGRYYALQWSLVVL 67851
67852 AKMIREFDFEMADPEYELALDGWFNIRPIDFYVKVKPRAT* 67974
CYP541A3 Chaetomium globosum CBS 148.51
GenEMBL AAFU01000004.1
66% to 541A1
89914 MSTPIPQPPGVPLLGNIFDVDPSNTWWSLKTLAEKY (1)
89700 GEIFQIKVLGHRIVFVASAALAEEICDEKRFRKYVGGPIVEIRYTVHDALFTAYDHEESW 89521
89520 GIAHRIMVPQLTPDAVASHFDEVIQCTDGLIAKWSGLESGGRTRPMDDLNRLNLEANTLT 89341
89340 LFGKKLNCFEGPEHPMIKAMEDATSEAMKRPNRPKLLNWLIHDGKLKKATKVMRGFAADL 89161
89160 VKERQENPSERRDMLWTMLNVKDPETGKALTESQVIDEIVSMPIGSSTAPCAIAAAIYFL 88981
88980 LQNPDALVKARDEIDAVVGEGPFKQEHVSQLQYVAGLVRETLRLSCAAPGFNIEPIPK-- 88807
88806 KGDESPVLLAGGKYQVPHNQAMIIVLAGVNRDPAVFEEPLAFRPERMMGEAYEQLPSAVK 88627
88626 KWFGNGKRECIGKHWAWEFLVVVITKLISELDFEAADPNYQFKQDGWFNIRPIDFSVKVK 88447
88446 SRTR 88435
CYP541A4 Metarhizium anisopliae var. acridum Ma102
CYP541A4 Metarhizium anisopliae var. anisopliae Ma23
CYP541B1 Aspergillus nidulans
AN8004.1 49% to 541A1 505 clan
See fungal pages for seq
CYP541B2v1 Aspergillus fumigatus
GenEMBL XM_742988.1
67% to 541B1 49% to 541A1, 98% to CYP541B2v2 ortholog
MPTPIPLPSGLPILGNLLSISPGNTWGSFNKLAVNNKNFYPIFK
ITILGHDIVFITSAKLLEEICDEKRFRKCVTGPIVEIREAVHDSLFTAYHDEESWGIA
HRIMAPLMTPEAVIDAFAGMRETATDLVKKWTAGPRQRINVSNDMDRLNHAANMLCFF
DQRIHCLEGPEPSVLQAMEAATFEALRRPTRPKVLKWLIYQRRFDRYIKTMRDYAAEI
VAKRRAAPTEKKDMLHAIMHGTDPQTGKALTESQYLDEIINLFIGSATAANLVSFALY
YLMKNPHEIARAREEIDAVVGGPAAQLEHEHLARLPYCEAILRESLRLSATAPGFNIE
PIPDLEQPVLLAGGEYQVPNKQPLIALLAAVNRDPEVFEDPDAFKPERMVGEKYDRLP
SGVKKGFGNGKRECFGKRYAWEWSFMILVTIMKDVDFVLADKNYKTEVGGVNYNGAFS
TKPLGLFALTGPRQSV*
CYP541B2v2 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000015.1
97% to CYP541B2 Aspergillus fumigatus = ortholog
67% to 541B1
347217 MPTPIPHPSGLPILGNLFSISPGNTWGSFNKLAVNNKNF (1) 347101
347032 YPIFKITILGHDIVFITSAKLLEEICDEKRFRKCVTGPIVEIREAVHDSLFTAYHDEESWGI 346847
346846 AHRIMAPLVTPEAVIDAFAGMRETATDLVKKWTAGPRQRINVSNDMDRLNHAANMLCFF 346670
346669 DQRIHCLEGPEPPVLQAMEAATFEALRRPTRPKVLKWLIYQRRFDSYIKTMRDYAAEIVA 346490
346489 KRRAAPTEKKDMLHAIMHGTDPQTGKALTESQHLDEIINIFIGSATSANLVSFALYYLMK 346310
346309 NPHEIARAREEIDAVVGGPTAQLEHEHLARLPYCEAILRESLRLSATAPGFNIEPIPDL 346133
346132 EQPVLLAGGEYQVPNKQPLIALLAAVNRDPEVFEDPDAFKPERMVGEKYDRLPAGVK 345962
345961 KGFGNGKRECFGKRYAWEWSFMILVTIMKDVDFVLADKNYKTEVGGVNYNGAFSTKPLGL 345782
345781 FALTGPRQSV* 345749
CYP541B3v1 Aspergillus oryzae
GenEMBL AP007162, BAE61440.1
50% to 541A1, 66% to 541B1
MPSPIPKPKGVPILGNVFDLDGNNTWGSFNKLAKDYRPIFKINI
LGKDIVFITGAHLLEEVCDETRFRKCVAGPILAIRDAVNDSLFTAKHTTEEIISWGIA
HRIMAPLVSWEAVEQVFSGIQETTDDLIKKWTTGSRQRINVTNDLDRCNHAANMLCFF
DQRVHIMEGPEPAVIKAMGCATNEAMHRPFRLRIVNWLFHSRKWNAWIKTMRDYGKDI
VETRRANPTDKKDMLYALLEGKDPETGKGLTDSQVLDEIINIFIGSATAPNLIAFAMY
YLANNPDAAAKAREELDAVVGGPSVRIEHEHLARLPYTEGVLRESFRLSGVAPGFNIE
PIPENEGPVLLAGGEYEVPKGQALIAILAAVNRDPAVFEDPEAFKPERMVGENFDRLP
KGVKKGFGNGKRECIGKRYAWQWSFMVLASILKDVEFELADPNYKVGNDGVNCNGAFS
VRPQEMFVVTGPRARAA*
CYP541B3v2 Aspergillus flavus NRRL3357
GenEMBL AAIH01000171.1
the ortholog of Aspergillus oryzae CYP541B3v1 0nly 2 aa diffs
CYP541B4 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000007.1
note only 215bp from CYP661B2
66% to 541B1, 79% to CYP541B2
578942 MPTPIPQPPGLPILGNLFDLKPGNTWGSFNKLAVKY (1) 578835
578761 RPIFKISVVGHDIVFVTSAKLLEEICDEKRFRKCVTGPIVEIRQAVHDSLFTAYHNEESWG 578579
578578 IAHRIMAPLVSPDAVAEAFAGMRETTKDLIQKWTAGPRQRVNVCNDLDRLNHAANMLCFF 578399
578398 DQRIHCLEGQEPSVIKAMDAATNEAMRRAARPKLLNWLIYQRRFNAYNRTMRDYAAEIVA 578219
578218 QRRAYPTDKKDLLDALLHGKDPQTGLALTDSQHLDEIINIFIGSATSPNLVSFALYYLMK 578039
578038 HPQEITRAREEIDGVVIDQLEHRHLASLPYCEAILRESLRLCATAPGFNIEPIPGQE 577868
577867 EPVLLAGGEYQIPNKQPMIALLSAVNRDPEVFEEPDAFIPERMVGENYERLPAGVKKGFG 577688
577687 NGKRQCFGTRFAWEWCFMVLVTILREVNFDLADKQYQTAVEGINYNGAFSTKPLGLFAVT 577508
577507 GPRQRL* 577487
CYP541B5 Aspergillus terreus NIH2624
GenEMBL AAJN01000228.1
63% to 541B1
134658 MPSPIPQPKGYPLVGNLFDIDSQNPWGSFNKLALKNKY (1)
134844 RPIFKINILGKDLVFVTGAALLEEVCDEKRFRKCVSGPIVQIRDAVHCSLFTAYEKEM 135017
135018 EDWGIAHRIMAPMVSTEAVAELYSGMKETMPDLIKKWTAGPRQRVNVTNDLDRLNHAANM 135197
135198 LCFFNQRVDCVNGPEPPAIHAHEESTVEATRRSSRMKLVNWLFHQKKYDNYIKIMRDYGA 135377
135378 DIIAHRKAYPTDKNDMLNALMNGKDPQTGKGLTESQVQDEIINCFIGSATAPNLISFALY 135557
135558 YLMKNPDTIRQAREEIDAVV-GVSESVEQEHLARLPYCKAIIDETFRLSAVAPGFNLEPH 135734
135735 PDDEGPVLLAGGEYEIPRKQALIVLLSAVGRDPAVFEDPDAFKPERMLGEKFDRLPAGVK 135914
135915 KRFGNGKRECIGKRYAYEWSFMTLVSILKDVEFELADANYVMNNDGVNYNGAFSVKPQGF 136094
136095 FAVTGPRQRSGH* 136133
CYP541B6 Ajellomyces capsulatus NAm1 Score = 504 bits
GenEMBL AAJI01002279.1
98% to Histoplasma capsulatum G217B (anamorph)
55% to 541B1, 47% to 541A1
10797 MTTPIPGPPGVPLLGNIFDINPKDTWGSLKSLADKY (1) 10904
10960 EIYKVNALGHQIVFIGSAALLEEICDETRFRKCVTGPVVEIRRAVHDSLFTAYHHEKSWDV 11142
11143 AHRIMAPLVSPSAAEAMFTQMVECAATLVSRWTSDPGQRIDVTSDLQRSDLQSVLACYFN 11322
11323 QAANYFGGPEPSMIAAMQNSTLEAMKRPNRPKLLTRLLYQRKFDKDIKTMRSFAAEIIAN 11502
11503 RKSESAPKSDMLHALLNNPDPETGEVLGEERVIDEIITIFIGSATAPCLVSFAVYYLLQN 11682
11683 PEEIVKARDEIDSILGANGEITSSNLSSFAYCEAILREAFRLSAVAPAFNIEPIPSDEP 11859
11860 DEVQLAGGKYQISRKQPMIAVLSAVNRDPAVFDEPEAFKPERMLGEAYDKLPSGVKKGFG 12039
12040 NGKRRCFGKVPAWQWCLITLISILRKVDLTLANKDYKLASNGAFCVRPLEFFALA GPRER* 12222
CYP541B7 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_21802|Aspni1
67% to CYP541B3v1
See fungal pages for seq
CYP542A1 Neurospora crassa
AABX01000017.1 cont3.568 NCU09103.1 EST = AA902060
Neurospora crassa sequence contig 1.841 (supercontig 115)
66714 MFLLSLLTLYTIYIAYHRLYLSPLADIPGPRLAALTQWYEFYYEVILHGQYTFKIIELHK 66535
66534 QYGPIIRINPWEVHIADPDFHRELLPTNTNRRRHRTPFF 66418
gap in seq
65887 VEDPDFRAEITNGILTGSNYGKIFQHFPFLVPFLASIPPGMLAAISPFYRTFLHLRACIT 65708
65707 AQIGEIEKSLRSEEGKNAHLDIPHPTIFHSFVNTEALPPIEKSVPRIAQEGQV
65548 LVQAGTVTTSWALTISTFHLLDQHATALAKLRK (?)
LEQLPYLRAVIKESMRLSVGASGRITRVAPDETLRFK (?)
EWLLPPGTEVSMTSYQITTNPEIFPDPHAFVPERWLGKENEMRLDKYMT 65069
65068 VFGHGARVCLGMQLAYAEMYLMLSKMWRVWEGGPQVGGGEDEDG (?)
DAEMAEDWFIPVPYRGSKGVRVYFESY* 64766
CYP542A1P Neurospora discreta
JGI gene model fgenesh3_pm.C_scaffold_2000176,
stop codon in PERF motif, add green regions
88% to CYP542A N. crassa
See fungal pages for seq
CYP542B1 Fusarium graminearum
FG08809.1 AACM01000355 FGcontig1.355_scaffold5
old name = CYP580A1 Fusarium graminearum
See fungal pages for seq
CYP542B2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.1.1096.1
Necha1/scaffold_1:865645-867387
85% to CYP542B1 probable ortholog
See fungal pages for seq
CYP542B3 Fusarium oxysporum
91% to CYP542B1 Fusarium graminearum
See fungal pages for seq
CYP542B3 Fusarium verticillioides
98% to CYP542B3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP542B4 Metarhizium anisopliae var. acridum Ma102
CYP542B4 Metarhizium anisopliae var. anisopliae Ma23
CYP543A1 Neurospora crassa
GenEMBL AABX01000408.1
Neurospora crassa sequence contig 1.972 (supercontig 142)
b24b19.tfa_260cg@B24B19
27399 MPCAFAITLLTVLVVLLVVQRWLERKRLRGGSRPLPGPT (1) 27515
27652 NLPFIGRVHDIPEKGSWLKFHEWSKVYGPIYQTKMFGVTHVWIS
SEKIAHDLLSRRANIYSDRPQIPNLPDNRTSGDYLALLGRN (1) 27906
27974 DTWRRQRKLCNHLMHTSALASLHDYPTLERNRFLYLLSQSP
ENYIEYIEQFTSRTIARLSWGSAHPAQILRHTTFGLLETIS
PSGALPNVISFLRHLPLALSPWQKKEKARHDLEDKQFRSNI
GFVKRMMDVGRAEPSFIRTYLEEQQGSINSTSTNKKCDEQK
GKEAAADEAMHVVGLMAIAGALTIGSPIQSYILAMCHYPEW
QARLQEEIDTELGGRCPMWEDREKLPLLRAVVKEVIRWRPPVPT (1) 28720
28825 GIPHAVEKDDVYNGYFIPAGATIHALEW (2) 28908
29018 AITRDEQTYPQAETFNPSRFLVPSYPTYREPLTIYPNLSGF
SQFGFGRRTCQGVPIVEQDLFLTMGGMAWAFTISKKRDPVTGVEMPVHWNDYT
PLLIAKPCRFPFDAVPRDEEKRKKMREMYEE
CYP543A1 Neurospora crassa
XM_954194 with extension
MFGVTHVWISSEKIAHDLLSRRANIYSDRPQIPNLPDNRTSGDY
LALLGRNDTWRRQRKLCNHLMHTSALASLHDYPTLERNRFLYLLSQSPENYIEYIEQF
TSRTIARLSWGSAHPAQILRHTTFGLLETISPSGALPNVISFLRHLPLALSPWQKKEK
ARHDLEDKQFRSNIGFVKRMMDVGRAEPSFIRTYLEEQQGSINSTSTNKKCDEQKGKE
AAADEAMHVVGLMAIAGALTIGSPIQSYILAMCHYPEWQARLQEEIDTELGGRCPMWE
DREKLPLLRAVVKEVIRWRPPVPTGIPHAVEKDDVYNGYFIPAGATIHALEWAITRDE
QTYPQAETFNPSRFLVPSYPTYREPLTIYPNLSGFSQFGFGRRTCQGVPIVEQDLFLT
MGGMAWAFTISKKRDPVTGVEMPVHWNDYTPLLIAKPCRFPFDAVPRDEEKRKKMREM
YEEAVEGEEMERCESREERERTEGWMVEGGVRQKEEEIPWQSGVGLQRQVEGDVGAGV
GAGGGGASSEDRRGQDHAQGPQDTSQEEPDDASDSHSTTSSRLDSTASGSGSVIGTPS
ASWGSEPSLSLRGSSVESSDCDEHEHDELRVVTRTTPYKGEDGDDDGNEGMRMRSMGR
MRGRRVRIKTMSNASSTIGMEALMTPMTPTTPEKEGLPFKEMGIMGIMGM
GTMKLGIATRRVMEVEDMEDLERV
AVDDEMEVPGAWRW
CYP543A1 Neurospora discreta
JGI gene model estExt_fgenesh2_pg.C_50051,
there is a C-term extension on this seq
90% to CYP543A1 N. crassa P450 part, 84% to the whole seq.
See fungal pages for seq
CYP543A2 Magnaporthe grisea
AACU02000514.1
See fungal pages for seq
CYP543B1 Mycosphaerella graminicola
40% to 543A1, 38% to 543A2 next best is 35% to CYP5445A1
yellow from JGI model estExt_fgenesh1_pg.C_chr_40312|Mycgr3
See fungal pages for seq
CYP543C1 Mycosphaerella fijiensis
JGI gene model e_gw1.1.178.1
44% to CYP543A1 N. crassa
See fungal pages for seq
CYP544A1 Neurospora crassa
AABX01000494.1 cont3.721 NCU10011.1 (version3)
(GC BOUNDARY at exon 2)
Neurospora crassa sequence contig 1.1020 (supercontig 147)
13303 MGIIHEKAHYVVAVALVAFLIRAFVLSQWNTIKRNGERLK (2) 13184
13120 KPPNTLPLVGNGLQFLQSRWKLFSWFDACQRKFGYETVAISVPT
LPPGVLIHDPRNLDYVFKNEGIFTKGNFVKGRTWDLFGNGIINA
EGDFWKTQRKAGLSFLNTANLRVLTDVALPQYLSESISQLRSST
NGTVVDLQHVFHEITTKLMGKMAYN (0) 12650
12590 MAMHADDEFTVSFDYASGG
TAERFQNPLWFVTEIFLGAELRKSIAVVKNFGRHIVTKAVQDRQEKEFGE
EEGKLDQISGSLIQSLLDAIQDEQMVADAALTYLSAGRDTTGQALTWTFY
LLMRHPRVVAKIREEATQLLKEKNVTLTPDQFDSSLFNPVTMPYSMAVFY
EVLRLYPPIPFEIRQCNEDVTLPDGTFLPKSSILVWCLWAMQRSKLTWGD
DADEFRPERFLDGNKLISRSPSEFPVFYGGPRTCLGRKMAEAIAAQVIPT
MACLFDFVPTSDEERTSKTSLTLPMEGGLPVTVKTLTGEEREKLVRIPEI
RFSEH* 11616
CYP544A1 Neurospora discreta
JGI gene model estExt_Genewise1.C_60834
95% to CYP544A1 N. crassa
See fungal pages for seq
CYP544A2 Magnaporthe grisea
MG00452.4 58% to CYP544A1 AACU01001420 cont2.89
See fungal pages for seq
CYP544A3 Fusarium graminearum
FG08377.1 AACM01000335 FGcontig1.335_scaffold5
See fungal pages for seq
CYP544A4 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_1000764
Necha1/scaffold_1:2520778-2522398
77% to 544A3 probable ortholog
See fungal pages for seq
CYP544A5 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.40.11.1
Necha1/scaffold_40:94653-96155
50% to 544A3
genome annotation in progress
See fungal pages for seq
CYP544A6 Fusarium oxysporum
75% to CYP544A4 Nectria haematococca
See fungal pages for seq
CYP544A6 Fusarium verticillioides
94% to CYP544A6 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP544A7 Grosmannia clavigera
CYP545A1 Neurospora crassa
AABX01000329.1 cont3.414 NCU07092.1 (version3)
Neurospora crassa sequence contig 1.1095 (supercontig 168)
long C-terminal
9756 MQLLTLVIVGLFMLIVAVVHFIKAFREVNDPNGI
PGPTQIPYLGRVHDLPIQFMWLKFKEWADKYGQQGFYRTMMLGAEFIVVT
DEKVAEDLLVKRAKYNSDRPVIQSLFDSKSTHGSMEYLPLM (1) 9382
9297 AYWARQRKLS
HSYLTEATKAHYYGVMYFEVQRWMARLLENPEDFQHSIEDMSSKVMCQLTWDDP
SLSEYCTKSAWGLLTQMSPAGPITNVLTPLWHLPTLINPWKRAERKRHDE
QQAWWMERLLTCREKLARGELRPCWTRQFLEKTSQKTSISGDYEASCVIG
MLALVGIFTVVGPMSYWLVSMVHNPKWQEAVQREVDEVCGNRMPRLEDAP
RLPILRACIKETMRWKPNVPTGVAHETEADDHYQGYFIPKGTRILPFDW (2) 8509
8448 SFLRNPVKYPDPENFRPERWLEPGWPTYKEPLTQYPTIKGLTSFGWGQRQC
LGMSLTQDELIVGCGALAWLFNLRHKRDPITGRELPVPLDRSNSLLIIKP
DPFQMEFEPRSKERKKEALRVWKESEAKDRARRERWLRNVKEGKPNVIKE
PKVLQPTVKIPSPSPAAAVPAALVDGGEVRDELSKTVQVVKEKSGGVNGH
GDSLAEKAVMDVKKKADISITIARLDSTACVY* 7747
CYP545A1 Neurospora discreta
JGI gene model e_gw1.6.180.1
92% to CYP545A1 N. crassa
See fungal pages for seq
CYP545A2 Mycosphaerella fijiensis
JGI gene model e_gw1.1.252.1
62% to CYP545A1 N. crassa
See fungal pages for seq
CYP546A1 Neurospora crassa
TWO PIECES AABX01000340.1 cont3.411
Neurospora crassa sequence contig 1.1100 (supercontig 168) N-term
Neurospora crassa sequence contig 1.1099 (supercontig 168) C-term
16866 MLSDKLLDLFALHKTQEALADVNLYKLLVLALALVLTAIIIDYG
YMLWLRSKMPTGPFPWPIIGNTFSLPENKPWIYFEELSKKYEKP
LITFWIGR 17153 (2)
17210 NPTIWINDAWCAHEILEKKAQIYASRPRMVVFGELGTGQKNLVT
MRILNNNDRDRWRIHRKLMHLGVGIQSVRGYREIQNNESKVVAL
DYLREPKEYVKHLERYATSVVSVIAFGRRVASYDDPIITEVIAL
MQLAADLNVPGKRFPMLLETFPXXXXXXXXXXXX 17671
145 RGGGQKGGGGGHYFFHSLALEALAQYESKSPLAKASMPTPYIKTLM
283 DASRQYSLPEAELSSLTGNLFGAGSDTSSSTLITFMLSCLAFPDA
MHKAQAELDRVLGGPAGGRSPHWDDAPNLPYINAYVKEVLRWRSV
AIIGGQPHSNTSPDYYKGYFIPPHSWVQGNVWAIHHHEREFPDPD
RFYPDRYLPGNDHHRPFPGEKGYMTFGWGRRVCSGQALAEQGTWI
SVARLLWGFTIRKYRDPQTGKEEEVDIFAYTNGLNMRPQPFRCEI
VPRSEEIREIIVREGEQALRDLKVLDGENRYRMSTFYQQKKREVA
EMPEFDEKGNIRMVKVK* 1146
CYP546A1 Neurospora discreta
JGI gene model estExt_fgenesh3_pm.C_60058
91% to CYP546A1 N. crassa
See fungal pages for seq
CYP546A2 Magnaporthe grisea
MG06557.4 64% to 546A1 AACU01000188 cont2.1218
See fungal pages for seq
CYP546A3 Grosmannia clavigera
CYP546B1X Fusarium graminearum name changes to CYP5065A1
CYP546B2X Nectria haematococca (Fusarium solani group)
86% to 546B1 probable ortholog
genome annotation in progress
name changed to CYP5065A2
CYP547A1 Neurospora crassa
AABX01000481.1 cont3.599 NCU09419.1 (version3)
Neurospora crassa sequence contig 1.1351 (supercontig 233)
b2h3.tfa_30wg@B2H3
MPPTGNPFNFARITLLALVEVLIVKKTSYRHVLAISTTSLVLAILAINYVFFLAWKLYLYPVYFHPLSKFPAPKV
VDLWRVLARFRGKVPPGQLLLELAERTPNDGIIILQGGFGTSMLITKPAPLADILVHHPYDFVKHDAIRNFLRPI
LGDGLVIVEGEQHRFLRKNTQPAFKFGHIKELYSTMWTKAIEMNHVLKEELREKGNDTSVEINAWAGKVTLDIIG
IAAFGRDFHVLERPDHPLVKNYADLLEPGPAKFAYFFLALTLSRKFVDLFPWEISRRFNRTTSNIRRICAELVRE
RKAAIEKLGDDQFDILSLLIRSNNFSEAELADQLLTFLTAGHETTSSAFTWAVYKLAQDGEMQSTLRSELKRALP
DFPRFAPGQDIAIILEHLPYLNGVMNETLRLYPTVPMTVRTATCDTTVLGHPIKKGTEIMISPWLINRYSDNWPS
ASTEFVPERWIDQEGKHIAEDGTEQPTQKPNNTGGVTSNYAQMTFLHGPRSCIGQGFAKAELRCLLATFVLAFEW
KLGMDEKDVMPDGVITIKPNNGMHLILRSLDGHQKG
CYP547A1 Neurospora discreta
JGI gene model estExt_fgenesh2_pg.C_80114
87% to CYP547A N. crassa
See fungal pages for seq
CYP547B1 Fusarium graminearum
FG11303.1 AACM01000464 FGcontig1.464_scaffold9
See fungal pages for seq
CYP547B2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.60.8.1
Necha1/scaffold_60:53804-55237
77% to 547B1 probable ortholog
See fungal pages for seq
CYP547B3 Fusarium oxysporum
80% to 547B1 Fusarium graminearum
See fungal pages for seq
CYP547B3 Fusarium verticillioides
95% to CYP547B3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP547C1 Aspergillus nidulans
AN8895.2 38% to 547A1
43% to 547B1 547 clan, 73% to 547C3, revised 7/18/07
MIPMLAATLAEAFILQRSVFTDTPLRTVVFGSAAVNLLILAIYNVWIWPF
FLDPLRHLPRAPGRFNMLRFIFDNPRGRLPLLWMKTVPNDGLIYFRDLLN
RTQLLATNHQALLDVMSTNTYDFEKPWRAREFLARIIGFGLILSEGAAHK
RQRRALTPFFTIKNVRALYTLMWDKTNQLLVEMDKQISRCPMEGTSPDSG
WGKVEMSVWARYFTLSRLTLDVIGPAAMGRDFRSLQNAENKVADSFLAIL
EPTKEKIAFLAINFLLPQWFAKKLPWRLNQVIEEQVGYLRDLCKEIVHEK
RAAITATKVTASELEADILGSMMLSGDFTDDELVDQMLTFLAAGHETTAS
ALTWTCYLLTLHPEVQDRLRAEIRTAIPHSTHPVTHSDLESLPLLNGVCQ
EVLRLYPTVPSTIREAVRDTTVAGKHVPKGTKIMLCPYAINRAPEFWGAD
GDAFRPERWIDTDPVTGKTSVNNHGGAATNYAQITFLHGQRSCIGKDFAR
AELRCAVAGVVGRYEFAMQDPKQ
VIHISGAVTTKPVEGMHLRMRRVEGW
CYP547C2 Aspergillus fumigatus
GenEMBL AAHF01000014
complement(join(100751..101365,101422..101806,
101859..102304,102353..102550))
locus_tag="Afu8g02610" first P450 of 8 on this accession
71% to 547C1 Aspergillus nidulans note: check SVWARYFTLSRLT for intron
MADTLLAIASVSLAEGYFLQRSVLKEYSFHSVCLGAVGVNLALK
IFWDFIIYPFFITANRHLPTVKGTFVNGKVIFDNPRGRLPLQWMKTIPNEGLIHFRDV
FNRSHLLPTTHQALLDIMSTNTYDFEKPWRAREFLARIIGFGLILSEGAAHKKQRKAL
TPAFNIKNIRSLYSLMWEKTGLFLDELEKEIRQNPMEGTSPEDGVGKVEMSMWAR (2)
LPSRLTLDIIGPAAMGRDFRSLHNPENKVADSFLAILEPTKEKMAFLAINFILPQWFARRLPWR
LNNVIDTETGFLRDLCKDIVREKRNTIVSSNMTAKELEADILGTMMVGGDFTDDELVD
QMLTFLAAGHETTASALTWACYLLTLHPDVQERLRTEIREHIPSGNHPISWSDLESMP
LLNGVCQEVLRLYPTVPITIREAVRDTTIAGKHVPKGTRILICPYAINRSPEFWGDNG
EEFLPERWIDHDKNGQKVVNHNGGASTNYAQITFLHGQRSCIGKDFARAELRCAVAGV
VGRFKFEMQDPKQEIHIAGAVTTKPVEGMHLKMSRVDEW*
CYP547C2 Neosartorya fischeri
97% to CYP547C2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP547C3 Aspergillus oryzae
GenEMBL BAE66568.1
73% to 547C1
MDLMLALITLSLVEGFLLQRTVFVDLTFRTVTLSSVGVNLVLLTIWNTLIYPYFVTPLRHLPTISGNLNN
ARIVFDDPRGRLPLEWMKTVPNEGLIHFRDIVNRSYLLATNHQALLDIMSTNTYDFEKPWRARDFLARII
GFGLILSEGSAHKKQRRALTPSFNVKNIRALYSLMWEKTGLLMDELEKQIKQNPMDGTNAQSGEGKIEMS
VWASRLTLDIIGPAAMGRDFRSLHNPENKVADSFLAILEPTKEKMAFLAVNFALPQWFARRIPWRLNKVI
NDETGFLRDLCRDIVHEKRASITATKATAKELEADILGTMMLGGDFTDDELIDQMLTFLAAGHETTASAF
TWACYLLTLYPDVQERLRTEIRERIPSGNHPITWSDLETLPLLNGVCQEVLRLYPTVPMTIREAVRDSVV
AGKHIPKGTRILLCPYAINRSPEFWGNDGEEFRPERWIDTDKNGQLVTNNTGGASTNFAQITFLHGQRSC
IGKDFARAELRCAVAGVVGRFRFEMQNPKQKIHIAGAVTTKPVEGMHLRMSRVDDW
CYP547C3 Aspergillus flavus
100% to CYP547C3 Aspergillus oryzae
See fungal pages for seq
CYP547C4 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_14000128|Aspni1
75% to CYP547C3
See fungal pages for seq
CYP547C5 Aspergillus terreus
82% to CYP547C3
See fungal pages for seq
CYP547C6P Aspergillus clavatus
65% to CYP547C2
RSPMGSCWQVSLLPSLRAGIAGRFRFEMQDPKQQIHIADAVTAKPVEGMHLKMSRIEGW*
CYP547C7 Aspergillus terreus
54% to CYP547C5 Aspergillus terreus
See fungal pages for seq
CYP547D1 Mycosphaerella graminicola
46% to 547B1
See fungal pages for seq
CYP547D2 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_60812
63% to CYP547D1 Mycosphaerella graminicola
See fungal pages for seq
CYP548A1 Neurospora crassa
AABX01000409.1 cont3.400 NCU06895.1 (version3)
Neurospora crassa sequence contig 1.1456 (supercontig 262)
ESTs b6f02ne.f1, b6g11ne.f1, b8g10ne.f1 (lower case = cDNA)
71638 MVFGAAHLQLWLGALVVLGAVY (0) 71703
71769 TSCLIFYRLFLHPLAKYPGPFLAKLTDG
YMAYHAFKGDRHLEFWRMHEKYGKFVRFGPNSLSVNSNTALKDIYGFKAN
VRKAEFYDAFVHPAPNTHNARDRDLHARKRRVLAHAFSDSAIKEVERYIL
SNIRTFCDAIGDLGRPSFAPLADKKGWSSPKNMSDWCSWLAMDILGDLCF
GKAFHMLERPDNRYAVDLVSVAAHRHLICGTMPMLDKLSLDRIFLRKIAS
GRAQYMAYSRQQLAERTALGDETDRRDFFYYLLKARDPETGQGFTTPELW
GESNLLIIAGSDTTSTAMAATLFYLVRNPTALARVTAEIRSRFASVEGIH
QGPSLQSCTYLRACIDEAMRLSPSVGGLLPREVLPGGITIDGEHVPQGTI
IGVPHYTIHHNAAYYPDPWSYTPERWLSTRSPSEKTSGAAMQTEEQIQLA
QSAFCPFSIGPRGCIGKGLAYIEMSITLARVLFLYDLRRAVGVDDPAEGG
KKGAEYGRHRVGEMQLVDTFTSTKDGVMVEFRPREDLAA* 73322
CYP548A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_80575
97% to CYP548A1 N. crassa
See fungal pages for seq
CYP548A2 Magnaporthe grisea
MG03375.4 74% to CYP548A1 AACU01000699.1 cont2.663
See fungal pages for seq
CYP548A3 Fusarium graminearum
FG06068.1 AACM01000241 FGcontig1.241_scaffold3
See fungal pages for seq
CYP548A4 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_3000360 same as e_gw1.3.949.1
Necha1/scaffold_3:1057950-1059702
87% to 548A3 probable ortholog
See fungal pages for seq
CYP548A5 Gibberella moniliformis = Fusarium verticillioides
GenEMBL ESTs DR630735 DR651021.1 DR621844.1
90% to CYP548A4
See fungal pages for seq
CYP548A5 Fusarium oxysporum
98% to CYP548A5 Gibberella moniliformis/ F. verticillioides
See fungal pages for seq
CYP548A6 Botryotinia fuckeliana B05.10
GenEMBL AAID01001234.1
59% to 548A5, 59% to 548A4
41% to 548G1 Aspergillus clavatus
MVELPSTSFILSGTLRALVFATTITAVY (0)
18189 LTTITIYRLTFHPLAKYPGPFLAKITDWYSVYHAWKGDRHLEFYRCHEKY (1)
17991 GPVFRYGPDSLSINSNTALKTIYGHKSNVKKSQFYSVFPPTKDTFNTHSSIDKA 17830
17829 SHARKRRVLSHAFSDNAIKTMEKYILGNVRTFCNNLGQPKASAEKSTGGWSVAQNM 17662
17661 SDWCNYLTFDVMGDLCFGKAFEMLENASNRHVIDLIGNAAHTHLI (0)
17481 TGTYPIIKTIGLSKILFRKIYAQRMKYMAYSRAQAAERTKIGLDTDRKDFFYYLLNARDA 17302
17301 ETGQGFTTPELWGESNLLIIAGSDTTSTALSAAFFYLVHNPDKLEILTKEIMSTFSDVEE 17122
17121 IHSSPTLNSCAYLRAVVDESMRLSPPVGGILPREVLPGGIDIDGLHIPAGYVVGTPHY 16948
16947 TIHHNPAYYPSPFTFLPERWIPSSSPQVTKDSVALAQSAFCPFSIGPRGCIGKGVAYVEL 16768
16767 MTSLARVVFMYEMRIAEGYTVGEGSEEMEVSRRRKEEYQLKDSFTSMKDGPYVEFRARAK* 16585
CYP548A7 Mycosphaerella graminicola
JGI gene model estExt_fgenesh1_pm.C_chr_130091|Mycgr3
61% to CYP548A6 Botryotinia fuckeliana
See fungal pages for seq
CYP548A8 Podospora anserina
EST CU891099.1
82% to 548A1
MAFGAAHVQLWLGLLAVAGLLYTS
CLVIYRVFFHPLAKYPGPLLAKLT
DAYMLYYAWRGDRHLEFWRMHEKYGKFVRFGPNALSANSNTALKEIYGFRANVRKAEFYD
AFVHPAPNTHNARDRDLHARKRRVLSHAFSDGAIKEVERYILANIRTFCEAIGDYGRAIQ
DNKGWSAPKNMSDWCNWLAMDILGDLCFGKAFHMLDRPDNRYAVDLVGVAAQRHLLCGTM
PIVNKLSLDKILFHKIAAGRAKYMAYSRQQLTERTALGDETRRRDFFYHLLKARDPETG
CYP548A9 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1Plus.C_20402
72% to CYP548A7 Mycosphaerella graminicola
See fungal pages for seq
CYP548A10 Trichodherma harzianum (anamorph) Hypocrea lixii (teleomorph)
No accession number
Renata Del Carratore
Submitted to nomenclature committee July 15, 2010
70% to CYP548A4 Nectria haematococca
C-terminal piece 220 amino acids
CYP548A11 Metarhizium anisopliae var. acridum Ma102
CYP548A11 Metarhizium anisopliae var. anisopliae Ma23
CYP548A12 Grosmannia clavigera
CYP548B1 Fusarium graminearum
FG00037.1 AACM01000002 FGcontig1.2_scaffold1
See fungal pages for seq
CYP548C1 Aspergillus nidulans
AN7881.1 43% to 548B1 40% to 548A2 53 clan
See fungal pages for seq
CYP548C2 Aspergillus niger
AM270216.1
JGI gene model gw1.16.377.1|Aspni1
54% to CYP548C1
See fungal pages for seq
CYP548C3 Uncinocarpus reesii
75% to CYP548C2 A. niger
See fungal pages for seq
CYP548C4 Aspergillus clavatus
82% to CYP548C2 A. niger
See fungal pages for seq
CYP548D1 Aspergillus nidulans
AN9007.1 46% to 548A3 53 clan
See fungal pages for seq
CYP548D2 Aspergillus fumigatus Af293
GenEMBL XP_747856.1 also EAL85818.1
70% to 548D1 revised 3/10/2009
MLVQPLLENLSVWGAVQGILSLLGVLTLAYVTYNRFFHPLRSIPGPFLASITPWVQLYHGLKGDRHLWLH
RLHEKYGSHVRAAPNFVSINTDRGLHDIYGHGKRLRKANFYNAFPAIKGVYNTHNAIDKAMHGRKRRVLS
QAFSDQALKSMEDVMLLHVRQLCEILTGGLDGPKGEKSATAVFNLGDWFSYLTYDVMGELCFGKSFDMLI
SSGRRKLIELVDRAANRHYV (0)
CGLWMPLDTWHLDQILIHKLTNDRWNFIMNSRVEANERAKERT
QAGHDAKKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTTSTTMSATIFYLVRNPRAMELLRKE
IRENFSSVEEIVTGPKLNELVYLKACIDEAMRLAPAVPGAPPREVMEGGAMIDGVFLPEGTDCGTPTYSI
HRQPEYYREPEVYIPERWIEGATCQAGSESWTTSKESVELARRAFCPFSIGPRGCIGKSMAFMEMRLTIA
RLMFLFDLELADHKGEDEKGQLALVDHFTSAKYGPNVVVRKRV
CYP548D2 Neosartorya fischeri
96% to CYP548D2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP548D3 Aspergillus oryzae
GenEMBL BAE62732.1
81% to 548D2, 45% to 548A2
MLVQEVWKTLSIEGVVVGVSALLGLLSFAYVIYNRFLHPLRKFNGPFLASITPWVQLYHGLKGDRHLWLH
NLHQQYGSHVRVAPNFVSINSAQGLHDIYGHGKKLKKANFYNGFTAIKGVYNTHNVIDKTVHGRKRRVLS
QAFSDQALKSMEDVMLLHVRQLCTALAEQQTEGNKAEAQKTTVQNMGDWFSYLTYDVMGELCFGKSFDML
VSSGRRKMIQLVDRAANRHYVCGLWMPLDTWHLDQIVIHRLTNDRWNFIMNSRVEANKRAQERTQAGHDS
KKDFFYYLLNAKDPETGKGLTTPELWGEANVLMIAGSDTTSTTLAATIFYLVRNPRAMKLLKKEVREAFT
SVEEIVTGGKLNELVYLKACIDEALRLAPAVPGAIPREVMEGGAVVDGAFLPAGTDCGTPTYSIHRQPQY
YREPEAYLPERWIEGATCVTADDKWESTKDAVETARRAFCPFSIGPRGCIGKGMAFMEMRLTIARLMFLF
DMELADRQGEDEKGHLALVDHFTSAKQGPNVIVRRRDITV
CYP548D3 Aspergillus flavus
99% to CYP548D3 Aspergillus oryzae
See fungal pages for seq
CYP548D4 Uncinocarpus reesii
72% to CYP548D3 Aspergillus oryzae
See fungal pages for seq
CYP548D5 Coccidioides immitis
87% to 548D4
See fungal pages for seq
CYP548D6 Aspergillus clavatus
82% to CYP548D2
See fungal pages for seq
CYP548D7 Aspergillus terreus
84% to 548D3
See fungal pages for seq
CYP548D8 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_9000084|Aspni1
82% to CYP548D2
name typo: was labeled CYP584D3
See fungal pages for seq
CYP548E1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_5000761
Necha1/scaffold_5:2660663-2662388
76% to 548E2 Gibberella moniliformis
44% to 548A4, 41% to 548A3, 36% to 548C1, 35% to 548D1
See fungal pages for seq
CYP548E2 Gibberella moniliformis = Fusarium verticillioides
GenEMBL AAIM01001130.1
76% to 548E1, 42% to 548A4, 39% to 548A3
1931 MAIINSVTVFSSSQIFWGIVF
1994 LSFCYVAAVVVYRLYFHPLAKYPGPFWARISAVPAYYYTLRQDRHVWFWQLQEKY (1)2158
2221 GPTFRITPNSVLINTPTGLKTLFNNKANVKKAEYYKTYPRNVHVMTTWNTIDKAMHARKR 2400
2401 RVMNHAFSDKALRSCEPFIHSNIDRWIELLDQEIGEKKWSPSLNMARWADHLIFDTLGE 2577
2578 LCFGKSFGMKEHDSELRHIPTLMTDFMSTIHP (0) 2673
2725 IAYSPFAPLWA 2757
2758 WLKPRGLDFLLAAAAPPAFSKWQAFVEQCFTERVQVENNMRGLWEKGESRKDFFHYLFQA 2937
2938 VDPDTGKGYSKDELFGESESLIIAGSDTSAISLAAAFFYLSRYPHIQQKLAEE 3096
3097 VKSAFSTVDDIKGGPALYSCQYLRAVIDETLRMSPPVPADLSREVQEGGILVDGEY 3264
3265 IPEGMKVSTASYCMHHNPDIYPEPFKFRPERWIVDEKSECGVSPESVSLAESAFMPFSAG 3444
3445 PRGCVGKNLAYLEISLALAKTVYHFEIRRDFSSNLGGGSPNAIEGRRTVDQYQLRDIFVA 3624
3625 IRDGPMVQLAKRS* 3666
CYP548E2 Fusarium oxysporum (temp 548E4)
94% to CYP548E2 Gibberella moniliformis
See fungal pages for seq
CYP548E3P Fusarium oxysporum
pseudogene 69% to CYP548E2 Gibberella moniliformis
See fungal pages for seq
CYP548E4 Fusarium oxysporum (temp 548E6)
86% to CYP548E2 Gibberella moniliformis
See fungal pages for seq
CYP548E5 Fusarium oxysporum (temp 548E7)
frameshift at C-term
76% to CYP548E1 Nectria haematococca
See fungal pages for seq
CYP548E6 Mycosphaerella fijiensis
JGI gene model e_gw1.5.510.1
56% to CYP548E1 Nectria haematococca
See fungal pages for seq
CYP548F1 Aspergillus oryzae RIB40
GenEMBL AP007157.1d, BAE58762.1
complement(join(472501..473171,473240..473483,
473556..474019,474079..474229,475214..475264))
EST AB227122
42% to 548A4, 41% to 548A1
MQVGGLRSRVSVLVAIQLVSLIVYRIYFHPLSKIPGPLLPKITD
WYPAWCVWRGSSHTALWEGHRRYGSIGRCGPNSVSVCSQTGLMEIYSTKANVCKDESY
VVMSVGSHAPNTFSFIDKKTHAFRRKILFQAFTDNALNGVQDQILSHISEFCAMLNPP
PSNGAGQSSVWGPSVDIAPLCDYLAFDVISDLSYGRSFGMLKSDRYRYVPKLTRRLAR
RNATCMTQSKLWRYKLDRLFFAGFLKALRDFGLWIRHQGKERIRLGNNGPRKDCFHYL
LSGSDPKTGQGLTERELRVELLLLIVAGSDTVATSLSAVLFNLAHNQQALQKATAEIR
SCFEREEDIRLGTRLKSCSYLHACISESLRISPAVSNMPPRRVLPGGITVDGYYIPEG
TIIGTPIYALHHNEEYFPRPFKYEPERWLENEANGENPSTDDGLKRARAAFCPFSIGP
RSCVAKNLAWAELTLTLARVLFSYDVRLPPDHCEVEPDCCSSVPRDQSPEYKLRTWIV
SAREGPSLQFRPRNVKVP
CYP548F1 Aspergillus flavus
100% to CYP548F1 Aspergillus oryzae
See fungal pages for seq
CYP548G1 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000022.1
65% to 548G2P 39% to 548A3, 41% to 548A2, 42% to 548A4, 40% to 548A5
in the CYP53 clan part A
MILAVHNLLDSLTVYSWRLLTTGASLGLFFL (0)
IGLSVYRLFFHPYAKYPGPLLAKLTSWYAVYHSYVGDLHTDIWRCHQKY (1)
GDVVRYGPNRIVIDSEYGLK (1)
AIYGHGANVHKSKGYERVSFIPKVHATL
CTLDDARHKFYRRLMNQGLSDTNIRRMDNKLKSIASLFASSLGEPTDRFHKSEDPAGDGWSVPKNMSHW (1)
CDYFTFDVMSELVFSKSYNLLTDSTNHWIIEGVLGQ
MQRFGFLLQLPELETLKLNHLFFPEARRRAIRFSAKAREIMQERQSRQKEELNDILGNLL
AAKDPETGEGLPNAQLWVDTNLLIIAG (1)
SDTSSTGMAALFFYLSRNPTAYDRVIKEVRAVFNNPEEVAQGPLLNSCIYL
RACISEAIRLCPAVSGALWREVLDGGLSIPEMNIHIPA GCEVGTGIWSLNHNEKYFPDPF
AFRPERWIAEESGDEAVTLAKSALASFSVGPRNCVGKGLAIIEISLAIAAVISQYDFRKA
ETRCTEVGEGKGEFKGQFQTSWAFTSLKDGPYIQFRKYMPGSN* 306652
CYP548G2P Aspergillus nidulans
GenEMBL AACD01000017
old name = CYP668A1
poor match 53 clan similar to 548A3
pseudogene of CYP548 family
45% to 548A1, 40% to 548A3, 41% to 548A2
64% to CYP548G1 Aspergillus clavatus
344602 FFYLSRNPSAYDR (frameshift)
VTKEVRNAFLTPDSVCQGPKLSSCVYLRACIQEVLRLAPAVSGALW 344427
344426 REVLPGGLRIRIEGDTETLDIPAG 344355 (frameshift)
SLLGTGIWTINHNERYYPQPFSFRPERWIPEEFGE 344261
344260 EAVQLATAAFTTFSIRPWNCVGKALAMIEMTLAMAAVISHFDFRRADGAAGGLGEGKGSF 344081
344080 DGQFQTFWAFTGFKDGPMIQFRPRKY* 344000
CYP548G3 Fusarium oxysporum
58% to CYP548G1
See fungal pages for seq
CYP548G4 Metarhizium anisopliae var. anisopliae Ma23
CYP548H1 Aspergillus oryzae
GenEMBL AP007171.1 BAE64607.1
45% to 548C1, 50% to 548B1
14 P450 genes and 2 pseudogenes on this contig
MQAVALLRHVPLFAYVTAVPVALLAYVLAICIYRIWFHPLAKYPGPLLAKVTNLYGGYYAWKGDLHIDMM
RCHEKYGNYVRYAPNRVLFNTNTGLKEIYAYSKSFQKSAAYGAMVHRAPNTLTLIDKKQHGRKRRIIGQG
FGDAALRGFEGTIMSLVRKFCDELAKDISGRKAGEWSTPQNMGKWSNYLTFDIMSGIIFGESFDLIGSPK
NREIVKCIEDSNVRTGVLSQAGELSTRRLDRWLFPQAIQGRNAFIRFVNILLKKRMSAKPLKRHDAFSFL
LDAVDPETQQGFTPAEIGAESTTMIVAGSDTSSTAIASTFFYLCRNREWYEKAKEEVRAAFPGPDDVALG
PALNNCVILRACIDESLRMSPPASSSLWREVLDDGVIIDGQVVPRGYDVGTCIYAIQHNPDYYPEPFEYR
PDRWLDPVPEKVQLARSAFSPFSIGPRSCLGKGLAWTELMLTMAYMLSKYEFRSAPGEDEKVGGGHVDMG
AGRQREGEYQLRDHVTAAKDGPIVQVSFR
CYP548H2 Aspergillus niger
JGI gene model gw1.11.642.1|Aspni1
56% to CYP548H1
See fungal pages for seq
CYP548J1 Gibberella moniliformis 7600 chromosome 11 cont3.130
Fusarium verticillioides
26kb from a PKS
AAIM02000130
45% to CYP548H1, new subfamily in CYP548 CYP5115 may belong here too
41% to DR630735 DR651021.1 DR621844.1 Gibberella moniliformis cDNA
44% to XM_001273103.1 Aspergillus clavatus
43% to XM_001402423.1 Aspergillus niger
MPMSHMKTHWLPYAIRISRSITPPPLLIILLLAALSP (0)
VIGYVVYYAFFHPLAKYPGPFWGKFTGLRAAYHAWIGDVHIDMWKCHEKY
GPYVRYSPNYLLMNTTQAYK
57293 DVYGHNKNVRKSLAYLAMVHKTPSTFTLMDRHEHAWKKRILSQKLSDSAIRSFEPKITGM 57114
57113 IDRFCQYVCPPASTGKENTVSKPFNMSEMC (1) 57024
56947 DYLFFDLVTSIVFGENFDLIRSPWYRHIPPALARSNERISVIVQWPYVVWRRMDKVLFRN 56768
56767 SVAGRKDFLRFAHNLVTERVQRGSGDDVLSGLLDAADPTTGNKLTQDEIVAESILML 56597
56596 VA ()
GSDTSSTLLASLFFYLTRNPDKKDRLTREVRSKFSTREEICLG 56417
56416 PALNSCRFLYACIMECLRLTPPVAAAPFREVLKGGMIVDGHYVPEGTNVGTGLFSIQHNQ 56237
56236 EYFYSPFEFIPERWLSEGKNAGPHNPDAHVPFSIGPRVCLGRALAHAELSL 56084
56083 AMAIICWKMDFNVVESMKDIGAGNENAEYGRHRPGEFQLYDHITCARNGPMVEFRERSF* 55904
CYP548J1 ortholog Fusarium oxysporum
97% to CYP548J1 Gibberella moniliformis
See fungal pages for seq
CYP548K1 old name = CYP5115A1 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000308.1
47% to 548H1, 39% to 5114A1
37% to 5114A1, 39% to 548A3, 37% to 548G1, 38% to 548A6, 34% to 548D2
MNYLSVLVVAVAVTLLY (0)
43655 LIARVIYLAFFHPLAKYPGPFLSKFTCARASYYAWRGDIHIDIWRCHEKYGDYMRYGPNQL 43473
43472 YVNTPKGLRDVYGPTTSNKFLKSSHYEVMTHQAANTFTHRGGKEHLRRRRIMAQAVSTKA 43293
43292 QLEYEPRLVGHIQKFCNAVFKGEPMNMAKWCNYLAFDSMTDVVFGAQYNL 43143
43142 LGDEKFRYVPEMIEKSNVRISSLVQFPGLTWLRLDKHLFQEAIYARNRFLKFVFRLLSDR 42963
42962 RALSHGTARGVFENPSISLDVYSRLQDARDPVTGEGFGHDEIASESTTLIVAGSDTSACA 42783
42782 TASILFYLANNPHAYARVAEEVRAVRSSRPGHLAAADLAGCKYLRACIDEALRMSPPVGT 42603
42602 GLMREVAAPGGLVVDGHVVPMGCEVGVGTYAIHHSTRAFEDPFVYRPERWLAPDESAHAR 42423
42422 ACFVPFSAGIRSCLGKGLAYTEVTLTIGHLLWLGDFKLVADAELAAVGRGSRK 42264
42263 LGVDGRHREGEYQLYDHIAGQKNGPWLQFTRRAEVQ* 42153
CYP548L1 Aspergillus niger
JGI gene model gw1.12.692.1|Aspni1
51% to CYP548K1
See fungal pages for seq
CYP548L2 Metarhizium anisopliae var. acridum Ma102
CYP548M1 Aspergillus niger
JGI gene model e_gw1.8.742.1|Aspni1
67% to fgenesh1_pg.C_scaffold_4000313, 42% to CYP548A2
See fungal pages for seq
CYP548M2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_4000313|Aspni1
67% to CYP548M1, 44% to CYP548A1
See fungal pages for seq
CYP548N1 Mycosphaerella graminicola
48% to 548A6 N-term from JGI model e_gw1.10.623.1|Mycgr3
See fungal pages for seq
CYP548N2 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_160063
73% to CYP548N1 Mycosphaerella graminicola
See fungal pages for seq
CYP548P1 Yarrowia lipolytica
GenPept CAG83449.1
45% to CYP548A1 N. crassa
See fungal pages for seq
CYP548Q1 Coccidioides immitis
43% to CYP548H2
gc boundary at QAHQ?
See fungal pages for seq
CYP548R1 Histoplasma capsulatum G217B teleomorph: Ajellomyces capsulatus
45% to CYP548A2
See fungal pages for seq
CYP548S1 Aspergillus clavatus
45% to CYP548A2 Magnaporthe grisea
See fungal pages for seq
CYP548T1 Neosartorya fischeri
43% to 548E1
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP548T1 Aspergillus terreus NIH2624
AAJN01000173.1
92% to CYP548T1 Neosartorya fischeri = ortholog
See fungal pages for seq
CYP548U1 Aspergillus terreus
41% to CYP548A6 Botryotinia fuckeliana
N-term exon not identified
See fungal pages for seq
CYP548V1 Metarhizium anisopliae var. acridum Ma102
CYP548V1 Metarhizium anisopliae var. anisopliae Ma23
CYP548X1 Metarhizium anisopliae var. acridum Ma102
CYP548W1 Metarhizium anisopliae var. anisopliae Ma23
CYP549A1 Neurospora crassa
AABX01000759.1 NCU01573.1 cont3.66 (version3)
Neurospora crassa sequence contig 1.1496 (supercontig 276)
9a41.tfa_150wg@9A41
MLIALLAPFSLLIAYVLHHVLSHQTLLLKQIFSQTIFNTIQLARLIGPLDPYDPLTVPDQVIPDSNSASEISEAQ
ARANQRIDDARSIIDFSYAGPKIELEDRLRLRALANSRLVAAFGINTSLTSSSVSVHKKFRKLASASINKSRADW
QKLYGVCMDFLQREKARYGRTGIGLAECVRCLCFVVVLVSQFGVDDKKVDKNLVKRITDGINAQWLKSKEDGEAV
KTSDSLNHDLGMLFGNLKTSVAEENGTGKDTSIDPSEALGLIMPQYETLWRVVLLTYVTAYYTQYDKRSLKKRVK
DIPSCLGNAATEKEALKLAT (0)
EGLRLYPSNNSIYRAATGPGPLKSADVQACHRDFNVWGRDALEFRPERFDNLTPL
QEKAYFPFSLGSHKCPAFGGFGNRMVTMLVVSMGRALSPETGKLNFEDAQLDNRVGIILPTGRDEMENWSWDM (0)
SWEF
CYP549A1 Neurospora discreta
JGI gene model estExt_Genewise1.C_100543
84% to CYP549A1 N. crassa
See fungal pages for seq
CYP550A1 Neurospora crassa
AABX01000727.1 cont3.288 NCU05128.1 (version3)
Neurospora crassa sequence contig 1.1526 (supercontig 290)
EST AI399597 NCSP6F8T7 (lower case)
MTVENSIVQHALTVYHDLSTATKATLAISIAFILYRLLFRHESTRRKELPAWGPIEMGLVMYLLdgarngivyrv (2)
YSAIRRYGGSFYGISSANQTLIGYEDVDRLFSSQMNHALSIEWHGYGLFLRFFGFPDTPTLKKKVESTFKPWHSP
IERVFNNDAGATAAFERGNLPKIVSEFVSFSQEKEKMKRWELRADIKVIKQGEAVEANLSALIMDFGACFTIPPI
FGHDLLDRNPHLIEDIWKFDHVVPLLFINMPTWAPFKVMKEGIEARKRLLAGVEAFSRRVTQFQRGEKVDDGADI
SDVSDVVLERNtalernewsyqeraasellvlfasntntqpvlfwlilyiystpglvntlrqevapfitlsdshh
Dkkgitaintsglsrecqllksiiletlrlafgavstrfvkrpitvqdgnhnhklypgtflsvphsffqrdpsly
PdphkfvpdrfleTDPSSGKLVAKYGKLRPWGAGASMCRGRVFAEKELMAIGAALVTLWDISPVGGGEWTVPEMV
GGPGPVKPKEEVRVVIKRRVFGGVSSSE*
CYP550A1 Neurospora discreta
estExt_Genewise1Plus.C_130219
92% to CYP550A1 N. crassa
See fungal pages for seq
CYP550B1 Fusarium graminearum
FG05960.1 AACM01000237 FGcontig1.237_scaffold3
See fungal pages for seq
CYP550B2 Aspergillus nidulans
AN9214.1
55% to 550B1 7 clan
revised 7/19/07
MDCISQNSVIQRALLALYEHPVAYSVI
TAVFISVLCRKLLYKPRNYALFPVWATIEVAIASYLLRGDGIGRRVF (2)
SVIRRYGGSLFGITSTHQILVDFPGLDRFMARSLHTLNAEPVQYTIFTRTFGG
VDSPELKRKLKNSWKDLLAPIERLFLNDASAAAALDRACVLQQAASFVSF
SSSPAQMKRWELSAGIRVIPPAESGSPHKVEANLQSLTRDFGACMAIPLL
YGRHFLDGNPTLLDDFWKFDNELFPLLMIGVPEWTPLRIVKDGCAARARI
LRELEALYRRIDQSQCGEPVESGIDMSDVSGALFERSRIYKREGWSFPER
AAGDFAIFWGQNANTHPLLFWFLAYIYSTPGLLDTLRAEIAPYTCFASSQ
AKVPEITSIDFPGLSANCQLLKACLYETYRLVNEPISIRYVERPVTLTDG
SLQHTLKTGTWVSAAHSLTQHNASIFDNPAEFRPERFLETDQVSGKRVAR
YGRLRPWGAGAAMCKGRTFAEKELTSAAASIVSLWDIEPAYGQVWKLPGM
VPGTGVKRPVRDIRVLISRRQSIVVKGNDMSPSKGENHGKPLGV*
CYP550B3 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.2.919.1
Necha1/scaffold_2:2281734-2283431
51% to 550B1
See fungal pages for seq
CYP550B4 Fusarium oxysporum
78% to 550B1
See fungal pages for seq
CYP550B4 Fusarium verticillioides
93% to CYP550B4 Fusarium oxysporum
See fungal pages for seq
CYP550B5 Metarhizium anisopliae var. acridum Ma102
CYP550B5 Metarhizium anisopliae var. anisopliae Ma23
CYP551A1 Neurospora crassa
AABX01000129.1 cont3.541 NCU08716.1 (version3)
Neurospora crassa sequence contig 1.1539 (supercontig 295)
67094 MAVLNWASSRAATLSPCPRTAALVVITTWLLYAIGLAVYRLYFH
PLARFPGRKMAAVTTWYEFYYDFWYGGKYIFEIEKMHKEF (1) 66843
66762 GPIVRINPHELSIHDPEYYNELYVGSSKRRTNFWPLFQGCTDDTD (1) 66628
66552 VNHFMTIDHDLHRQRRKPFDPFFSRMAINIRYWPMLAEKASFLES
RIRECKGQGKAVRLDRAFSAFSADCIERICTDDLEPGDGFLDQPD
FGPEWYDGMLGLIRNAPILTKFPKALS (2) 66202
66144 SLRYVPPRLLLWLFPQGRIANKYDARTRTQIHKAVTKQHLSKD
TTTNSEHTTLFRALAQSDNLSPADKAEERLVREAKLIFLGGTIS
TGRTLSFVSYYILSRPDIKARLEDELRDVMATWPEVVPTWTELE
KLPYLQAVIKEALR (2) 65710
65588 LSYGFMRRLPRVSPDVAIQYKEYTIPPGTPVGMSAYLMHSNPEV
YQDPDQFVPERWLGGDTRVMQRSYVPFTKGSRSCLGQN (2) 65343
65254 LSMAEISLVLAVLFRPDGPRMELFETDESDVKHVHDFVVPLPK
LDSLGVRVMVR* 65090
CYP551A1 Neurospora discreta
JGI gene model estExt_fgenesh3_pm.C_100040
91% to CYP551A1 N. crassa, frameshift = &, modified green region
possible pseudogene
See fungal pages for seq
CYP551A2 Aspergillus oryzae
GenEMBL BAE62699.1
53% to 551A1 43% to 551B1 Fusarium graminearum in CYP53 clan
Note 551 is not in the 53 clan tree on part C where it belongs
MEDTFNLTVLGGVIVLYSLGLVIYRLYFSPLAKFPGSKLAAATGWYEFYFDYWIGGKYVFEIERMHQVYG
PIIRINPHELSIRDPDFYNEIYVTENKRRSNHYDLFARGIGMDDARVESHIVTVDHNLHRKRRKPLEPFF
SRAGIARLEPALVEMSLKLESRLRQYEGKHTVVTLDHAFSAFSGDIIRRVCFNKDDFGDLFMDHPDFSPD
WYNLIHNILRHFPVFTGFPLIARIVTYIPESILLKAFPQGQSLNRLKDVALQRITHVMNSKATELKDTHR
EVSLFHHIVESDMPESERSPERLVQEAQVLLSAGTVTTARTIAFASFYILARSEIKAKLQAELRDAMDGW
PEKVPTFMDLERLQYLQAIIKESLRLSYGIMHRLPRVSPDLPIQYKDFTIPVGTPVGMSSYFMHTDPTVY
PDPMTFRPERWLGAIDPAMHRNYVPFTRGSRNCLGMNLAMAEISLILAVLYRPNGLKLELYETDETDVMI
AHDFMAPMPKVTSKGVRVLIR
CYP551A2 Aspergillus flavus
99% to CYP551A2 Aspergillus oryzae
See fungal pages for seq
CYP551A3P Aspergillus nidulans
AN5460.3
About 47% to CYP551A1
VTFYCASLIIYRLYFHPLAGYPGPKLAAATRW
YEFYYDVIRQGKYVYEVNQMHDKY ()
PIVRINPHEIVIKDPEFYNQIYVAGNTRRTEKWXXXXXXXXXXX
GSIVMTVGHELHRLRRKPLDPFFSRMEIDRLEPLIVKEAKLLNHRLQSYSGSGRVLRLADVF
SAFAVDMITHICSEAGPVMMNKPEFGKDW 224
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
ETKNSLFRQLLSPSSA
GGLPESELDAERLASETMVLFGAGTVTVTSTLSLICYYILRDSHIRDRRAGELEGVMAQYPTSMPTWQQLER
LPYLHALVQEGLRLSYGTMRRLPRXX
PDAALHYKQWTIPP (frameshift)
TPVGMAAYSLHTDPEVYPDPFEFL
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXX
(Missing PERW and heme signature)
LAYAEVYWALAVMFKSNAPKLQLFETEKMDVEHVVDSMVALLRLGSQETRITV
CYP551B1 Fusarium graminearum
FG01739.1 AACM01000092 FGcontig1.92_scaffold1
See fungal pages for seq
CYP551C1 Coccidioides immitis
51% to CYP551A2 Aspergillus oryzae
48% to CYP551B1 Fusarium graminearum
See fungal pages for seq
CYP551C2 Aspergillus clavatus
75% to CYP551C1
See fungal pages for seq
CYP551D1 Mycosphaerella fijiensis
JGI gene model e_gw1.2.71.1
49% to CYP551C1 Coccidioides immitis
CYP551-un Magnaporthe grisea
MG06589.4 53% to 551A1 PERF to heme
probable pseudogene fragment
AACU01000192.1 cont2.1224 continuation of MG06588.4 +1800bp
FGFMVRLPQCSPDVKLQYGKWKTPRN (0)
TPVGILAYLMHTD
79064 PTIFAEPYEFRPEGWLEGQVISAMKQAYVPFSKGSRACLGSI (1) 79189
CYP552A1 Neurospora crassa
AABX01000480.1 cont3.625 missing about 32 aa
at N-term (GC boundary at exon 2?)
Neurospora crassa sequence contig 1.1554 (supercontig 301)
sequence runs off beginning of contig missing about 33 aa at N-term
2 FFHPLRHIPGPKLAAASYIPEFYWDVLRGGMYQKRILLMHEKY (1) 130
229 GPVVRISPNEVHCNDWRFIDEIYASGSRKRDKPLHQVRGSGG (2) 354
419 IVDATFSTTSHDLHRMRRNALNKFFSRAQVARLEPTVRENAERIC
DKILILGKSAPFDVTTAYSHFTTDVISGYCLGDSLGLIEQKGWEP
NFREPLYAQLKLMYWLRFIPLFKRLS (0) 766
888 WYVFFGESFLPCPVSLTNYDIQGDMPRYVRRAQDNVIKGLDDG
SSVFGALLTSDLPPSEKSLERLTDEGFSLFAAGTETVSWALSVIT
YHLFANRELLEKVTKEVTQVIDAKSGQLPSWHTLEKLPYLGGVIY
EGLRLSYGVASRSSRIPVGEDLVYRG (0) 1364
1407 YVIPRGYAIGMSPLSIHHDETVFPNSHSFIPERWIDDNDQHRKEL
DRALLSFSKGSRSCLGIN (2) 1595
1657 LAYCELYVLLSLLIVRVFPHMKLHETTEVDVTHDHDFFNPFPVSS
SKGVRAIVV* 1821
CYP552A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_150001
84% to CYP552A1 N. crassa, missing C-term, added below
yellow regions do not match N. crassa
See fungal pages for seq
CYP552A2 Aspergillus nidulans
AACD01000032.1 AN2040.1
53% to 552A1 50% to 552B1
revised 7/18/07
MTISAETVLRLLPLTAGGAWVFFHLAKCIYNLFFHPLSHIPGPWLAAATY
LPEFYHDVVRGGRYTTQIQQMHEKYGPIVRINPHELHCNDHRFINEIYAG
GTRKRDKPVHQVTGSEAAAHATFSTTDHDVHRMRRNALAKFFSRAQVLRL
EPTVRGLAERLCDKMLRTEKGRPFHVGAAYSQFTADVISGYCLGENLGLM
GQEGWEEQIVDEVATVLRLGCTLRFVPWWKHVLGVVLLIRKQLVGSPKES
SDALIVGMPNHIRKAQADIKIMDGKGNGNGPETIPTTVFTSLLQSDLPPQ
EKTFERMTSEGISLFAAGTATVSWALTVATYHLLTKPAILQRLTAEVSDL
VNSSSCTEKVEWSALERLPYLGAVIQEALRLSYGVASRTARVATGEDLVY
RGEWAHREVQYIIPRGSAIGMSAVLAHHDEAVFPDSHLFLPER
WLDEKNQRLKELDRALLAFSKGSRGCLGIK
LAYCELYLLLALLVVRVFPRMRLYGTTEADVAYDH
DFFNPFPVWESKGVRVVV*
CYP552A3 Grosmannia clavigera
CYP552B1 Magnaporthe grisea
AACU02000500.1 Magnaporthe grisea 70-15 revised
See fungal pages for seq
CYP552B2 Magnaporthe grisea
MG03828.4 51% to CYP552 AACU01001030 cont2.747
See fungal pages for seq
CYP552B3 Fusarium graminearum
FG11038.1 AACM01000458 FGcontig1.458_scaffold8
See fungal pages for seq
CYP552B4 Fusarium oxysporum
79% to CYP552B3
See fungal pages for seq
CYP552B4 Fusarium verticillioides
92% to CYP552B4 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP552C1 Magnaporthe grisea
MG06623.4 41% to 552A1, 46% to MG01924.4
AACU01000198 cont2.1232
See fungal pages for seq
CYP552C2 Fusarium graminearum
AACM01000116.1 Gibberella zeae PH-1 revised
See fungal pages for seq
CYP552C3 Fusarium graminearum
FG08186.1 AACM01000329 FGcontig1.329_scaffold5
See fungal pages for seq
CYP552C4 Fusarium oxysporum
84% to CYP552C2
not in the F. verticillioides genome
See fungal pages for seq
CYP552C5 Fusarium oxysporum
92% to CYP552C3, 65% to 552C4
not in the F. verticillioides genome
See fungal pages for seq
CYP552C6 Aspergillus terreus
80% to CYP552C4 Fusarium oxysporum
See fungal pages for seq
CYP552D1 Magnaporthe grisea
MG01924.4 poor match 46% to MG06623.4 AACU01000373 cont2.362
See fungal pages for seq
CYP552E1 Aspergillus nidulans
AACD01000108.1 Aspergillus nidulans FGSC A4 revised
See fungal pages for seq
CYP553A1 Neurospora crassa
AABX01000379.1 cont3.619 NCU09565.1 (version3)
Neurospora crassa sequence contig 1.1649 (supercontig 337)
26616 MPSTMADAVAEIESLLDTGIAAIKGLIP
MIWVQSKTSPVQFLVGGVAVLLSYLLLTISPPHDPSEPPLIKPR
FPVIGHLFGLLNHQVNYFSELFARYHLPIATLPIGNQKLYVIFD
APLQQAALKAKDMDAQSFMVDFVPRIFGVKQGTVDKLLGKDGVH
PNIMGDMEQVFKSALSGDNLQKLASTTLATMADTLNDVDSKKGT
KIPNMFLWLQSLLSRSTSKALWGEKHNPFKDHQVIDAQW (2) 25888
25827 DFESHLGPLVLGVLPSIVARRAYLARNKVQSALLSYFSARHYET
DPSTSYFIRARTRLLKRYDLPDDELAKNEVAITLVATTNVLSTL
FWCIAEIWTRPDLLQQIRAEALLAVFGNSQKALSGEDMGTRTIT
IPATGLDAKCPLLASCFRESIRLASQIVTARRVLKDTLLTDPVS
GNSYLLKADTNVMMPAKVVHRNTSVWGADAEGFNPRRFMWEELG
PKVERQRKAAFVPFGGGKHMCPGRHFAFTENLALMAALAIGFEI
EGLDRSKLKMGDSKRGETAKPLPGLEGGEVVLKKRKGWEGVEWEFSC* 24892
Note: several Neurospora P450s were named previously or fall into existing families
51, 54, 53A4, 55A6, 61, 65B1, 65C1, 68D1, 505A2, 507A1
There are 12 fragments of Dictyostelium P450s that are not named because they
are too short or not similar enough to named P450s. These sequences are
numbered with temporary tags. P indicates a pseudogene.
Seqs 17, 37, 40, 41, 51, 52, 57P, 60P, 76, 84, 89P, 90
CYP553A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_80731
93% to CYP553A1 N. crassa
See fungal pages for seq
CYP554A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 40
CYP555A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 76
CYP556A1 Dictyostelium discoideum (cellular slime mold)
See lower eukaryote section for accessions and sequences
Formerly seq 92
CYP557A1 Rhodotorula sp. (a basidiomycete fungus)
GenEMBL AY316198
Shiningavamwe,A.N., Albertyn,J., Moleleki,N. and Smit,M.S.
Cloning of a cytochrome P450 (CYP557a1) from the yeast Rhodotorula
(CBS 8446)
Martie Smit Department of Microbiology, Biochemistry and Food Science
University of the Free State P.O. Box 339
Bloemfontein 9300 South Africa
Submitted to nomenclature committee 11/19/2002
CYP558A1 Achlya ambisexualis (an oomycete Stramenopile)
No accession number
Shelley Brunt, Julie Silver
Submitted to nomenclature committee August 1, 2003
No obvious similarity to any other P450 family
CYP559A1 Neurospora crassa
GenEMBL WGS section AABX01000439.1
100% match to XM_325821.1 mRNA prediction
See fungal pages for seq
CYP559A1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_130397
93% to CYP559A1 N. crassa
See fungal pages for seq
CYP559B1 Magnaporthe grisea
MG00572.4 50% to 559A1 AACU01001430 cont2.99
See fungal pages for seq
CYP559B2 Grosmannia clavigera
CYP559C1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_20000187
Necha1/scaffold_20:493296-494983
47% to 559B1 Magnaporthe grisea
See fungal pages for seq
CYP559C2 Fusarium oxysporum
71% to CYP559C1 Nectria haematococca
See fungal pages for seq
CYP559C2 Fusarium verticillioides
95% to CYP559C2 Fusarium oxysporum ortholog
See fungal pages for seq
CYP559D1 Mycosphaerella graminicola
42% to CYP559B1 Magnaporthe grisea, 41% to 559A1, 39% to 559C1
See fungal pages for seq
CYP559E1 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_70615
45% to CYP559D1 Mycosphaerella graminicola
See fungal pages for seq
CYP559F1 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_130046 revised at N-term
45% to CYP559D1 Mycosphaerella graminicola
41% to CYP559E1 Mycosphaerella fijiensis
See fungal pages for seq
CYP559G1 Metarhizium anisopliae var. acridum Ma102
CYP559G1 Metarhizium anisopliae var. anisopliae Ma23
CYP560A1 Neurospora crassa
GenEMBL WGS section AABX01000445.1
100% match to XM_331965.1 mRNA prediction
See fungal pages for seq
CYP560A1 Neurospora discreta
JGI gene model estExt_fgenesh3_kg.C_80010
93% to CYP560A1 N. crassa
See fungal pages for seq
see fungal pages for details on these sequences
CYP561A1 Magnaporthe grisea
MG00301.4 39% to 65B1 AACU01001402 cont2.70
See fungal pages for seq
CYP561B1 Magnaporthe grisea
MG09637.4 probable polyketide synthase AACU01001669 cont2.1850
See fungal pages for seq
CYP561C1 Magnaporthe grisea
MG00059.4 37% to several families AACU01001358 cont2.16
See fungal pages for seq
CYP561C2 Magnaporthe grisea
MG03825.4 poor match 53% to MG00059.4 AACU01001030 cont2.747
See fungal pages for seq
CYP561C3 Magnaporthe grisea
MG02329.4 poor match 54% to MG00059.4 AACU01000455 cont2.461
See fungal pages for seq
CYP561D1 Fusarium graminearum
FG01740.1 AACM01000092 FGcontig1.92_scaffold1
See fungal pages for seq
CYP561D2P Fusarium oxysporum
pseudogene 51% to CYP561D1 Fusarium graminearum, & = frameshift
See fungal pages for seq
CYP561E1 Fusarium oxysporum
39% to CYP561C3
See fungal pages for seq
CYP561F1 Metarhizium anisopliae var. acridum Ma102
CYP561F1 Metarhizium anisopliae var. anisopliae Ma23
CYP562A1 Magnaporthe grisea
MG05390.4 poor match 41% to MG10954.4
AACU01000502 cont2.991
See fungal pages for seq
CYP563A1 Magnaporthe grisea
MG07593.4 37% to 65A1
AACU01000919 cont2.1406
See fungal pages for seq
CYP563A2 Botrytis cinerea = Botryotinia fuckeliana
GenEMBL AJ851088
join(852..944,995..1157,1224..1300,1351..1597,1658..2661)
aba2 gene (note: CYP527D1 = aba1 gene)
57% to 563A1 in the CYP53 clan part A
MLLSIKDLSEKYIMLLDVKDLSTLKTTVAVLVTVALIAQVLWKI
FFHPLSAFPGPWFNRISEIPGSWVIATGKQHSYYRKLHEKYGPVVRVAPNELSFIGDR
AWDDIYGVQKKGPNFEKSPIFIGAVSPLDGQTGISLAPNEAHTRQRRALAHVFSNTAL
LQQEEIMRSHVDKLVGQLKKTIAENRPINFSNWYTYTTFDMMGDLCFAEPFGCLDQGG
ATEWSTSVINVFKSAAWDQSIRRVAGVNTWLQKLMVKLLIPSKAANWRKVHFQNSREK
TLRRLADGNREHKDFIYHILKNKEAKNSLSETEIILNMVLLISAGTETTASLLTGWTY
FICTHPEVYKRLTDEIRGRFNSEQDITWETVKDLPYLHATLSEALRLYSPAPANQQRI
VPPGGSVIDGHFVPGKTTVAVAPWAAINSSLNFKDPQKFIPERWLGDERFVNDKLNAS
QPFSLGPRGCIGKNLSFFEMRLITSRLLWNFDVSLVTTGEHGETNKLWDMDGAGKYMK
VYQTWNKPDMWVMLKEVPR
CYP563A3 Metarhizium anisopliae var. anisopliae Ma23
CYP563B1 Magnaporthe grisea
Magnaporthe grisea AACU01000984 cont2.1481 MG07982.4 C-TERM EXON
AACU01000985 cont2.1482 N-TERM PART (3/4) RUNS OFF END
See fungal pages for seq
CYP563C1 Mycosphaerella graminicola
50% to CYP563A2 Botrytis cinerea, 45% to 563B1 Magnaporthe grisea
See fungal pages for seq
CYP563D1 Mycosphaerella graminicola
42% to CYP563C1 Mgr027, 42% to 563A2
See fungal pages for seq
CYP564A1 Magnaporthe grisea
MG07550.4 40% to 65B1 AACU01000913 cont2.1400
See fungal pages for seq
CYP565A1 Magnaporthe grisea
MG07497.4 poor match 51% to MG03433.4
AACU01000908 cont2.1394
See fungal pages for seq
CYP565B1 Magnaporthe grisea
MG03433.4 poor match 51% to MG07497.4
AACU01000709 cont2.676
See fungal pages for seq
CYP566A1 Magnaporthe grisea
MG01947.4 poor match. first exon is best guess
AACU01000379.1 cont2.368 revised 7/18/07
See fungal pages for seq
CYP566B1 Fusarium graminearum
FG04590.1 AACM01000193 FGcontig1.193_scaffold2
AACM02000109.1 47% to 566A1 revised 7/18/07
See fungal pages for seq
CYP566C1 Aspergillus nidulans
AN2610.1 38% to 566A1 53 clan
revised 7/18/07 NW_101284.1, 79% to 566C2 N. fischeri,
79% to 566C2 A. fumigatus
MTLIESSPAQFTLVACSL (0)
GVAFLVLIVVYSYFFHPLARVPGPWTGAVFP (0)
309588 FWSISTLYRRRLNPDLAELHKIY (1) 309535
309472 GPVVRVGPNQLSFATIEAQKMIYNAKPTNNGSDEH
FGRDGTLQDVLLSMILGAPNIGSLSNRAEHKKMRK
RLLPGFTSNTIFEQEPLLRLHVDQLLHRLAQDAGLINLTSHFSRFLWDLI
GDFSFGEPLVPEKH (1)
ELRTDKLKSMVEIYQGCFPLLEAINHVVPEINAVIRLAFRLVPPATLRAVLPTATLRG (2)
CVDRQDGRSDFLTHIMGDKSRDPTELEL
SYDEVHSNATVLM (2)
IAGYKTTETSLSALFYRILSTPGVLKNLQSELFSNFQ
SIDGITGRKLLSLPYLNGCIYESLRLAPPVAGKFASRRSPGAVIQGFYVP
PGTEVFTETYTMQRSPLYWYAPDEYHPERWLKQSEGSPYAQDVHEAFKPF
SSGPRACLGREMALQTLRLTTALLAYRFDMEMVNEDQFVWEQDTESRMVY
SQYQIKAVVQEHLT*
CYP566C2 Aspergillus fumigatus Af293
GenEMBL XP_750865.1 also EAL88827.1 NZ_AAHF01000006.1
89% to 566C2 N. fischeri, 79% to 566C1
MGAQQFKAMSAISPEQVAIMACSL (0)
GTGLLVSVVIYNYFFHPLARVPGPWTGAIFP (0)
FWTMSSLYRRTLNPDLAELHKRY (1)
GPIVRVGPNQLSFATVEAQKMIYNAKPTHTGSDELFGREG
TLQDVLLSMILGAANIGSLSNRAEHKKMRKRLQPGFTSKALFEQESLLRLHMDRLLERLAQDTGVIDLT
EYFSTFLWDLIGDLSFGEPLVREKH (1) 1072139
1072086 AALHTDTLRSLVALYQGCFPILEAINYAVPQIEGVLRLAMQLVPTATLRAVLPSATFRD (2) 1071910
1071773 CIDRQDGRSDFITHITGDKSRNPTELELSYEELHSNATVIL (2) 1071651
IAGYKTTETSLSALFYRLLSTPGVLKKLQSELFRNFPSIDEITGKKLLSLPYLNGCVNES
LRLTPPVAGKFASRRSPGAIIEGFYVPKGTEVFTETYTMQRSPQYWHAPDEYRPERWVERGEGSPYAQDV
HEAFKPFSSGPRACLGREMALQTLRLTTALLVYRFHMKIVDEKRFVWEQDTDSRMIYSQYQIKAILQDRLT*1070978
CYP566C2 Neosartorya fischeri NRRL 181
NZ_AAKE03000024.1, XM_001258096, 89% to 566C2, 79% to 566C1
Name revised from CYP566C3
189543 MDAQHLMTMSGISLEQVAIMGCSL (0) 189469
GTGLLVSMIIYNYFFHPLARVPGPCTGAIFP (0)
FWSMSSLYRRRLNPDLAELHKKY (1) 189182
189121 GPIVRVGPNQLSFATVEAQKMIYNAKP
THTGSDELFGRDGTLQDVLLSMILGAANIGSLSNRAEHKKMRKRLQPGFTSKALFEQESL
LRMHMDRLLQGLAQDTGVIDLTEYFSRFLWDLIGDLSFGEPLVPEKH (1) 188720
188664 GRRTDTLRSLVGVYQGCFPILEAINYAVPQIEGVLKLALQLVPPATLRAVLPSATFRD (2) 188491
CINRQDGRSDFLTHIMGDK 188299
188298 SSNPTELELSYDELHSNATVLM (2)
IAGYKTTETSLSALFY 188119
188118 RLLSTPGVLEKLQTELFSNFQSIDEITGKKLLSLPYLNGCVNESLRLTPAVAGKFASRRS 187939
187938 PGAIIEGFYVPSGTEVYTETYTMQRSPQYWHAPDEYRPERWFERGEGSPYAQDVHEAFKP 187759
187758 FSSGPRACLGREMALQTLRLTAALLVYRFHLKIVNEDRFVWEQDTDSRMIYSKYHIKAIV 187579
187578 QERLT* 187561
CYP567A1 Magnaporthe grisea
MG03819.4 poor match defective KYG seq motif
like CYP65s possible pseudogene? AACU01001030 cont2.747
See fungal pages for seq
CYP567B1 Fusarium graminearum
FG10695.1 AACM01000446 FGcontig1.446_scaffold7
See fungal pages for seq
CYP567B2 Fusarium oxysporum
85% to CYP567B1,
This seq is missing in F. graminearum
See fungal pages for seq
CYP567B2 Fusarium verticillioides
81% to CYP567B2 Fusarium oxysporum probable ortholog
See fungal pages for seq
CYP567C1 Aspergillus nidulans
AN1737.1 47% to 567B1 53 clan
See fungal pages for seq
CYP567D1 Aspergillus nidulans
AN3281.1
41% to 567B1 53 clan
revised 7/19/07 89% to A. clavatus CYP567D3
MSASWVDEPSSLLGIFEVVFVL (0)
KRHPNGSELQTLVYVSTRILYNIYFHPLAAFPGPLLARASM (0)
AWRIYHSMGGRFHRAIDEQHRRY (1)
GPVFRVSPNELSFASVASWKDIYGHRAT
GKPPLIKSKFYEIYGAGFGSLCIGSERDPEKHTRMKKSLSPAFSLRSLGD
QEVIVSQCVDRFVSRMGEPELNAGGLNMTKWYEMVAFDILGEL (1)
AFGESFHSIED (1)
GKPHFWSSLIEDHLYFITVADNFRHFPVVALIAKLLSPFLDSIRKKHTGYTRNKVAQ (2)
RIRSSSPRKDFMANLIGKVESNEMSREELTAHASTLV (2)
IAGGETVATFLAATTFYLLRDD
AVYQKLKAEIRGQFNTYEEITCATAQNLPYLQAVISEGLRIYPPGSQGFP
RISPGASIDGIWIPAG (0)
AEVYTSAWTVTHDEANFHDPHTFKPERWIDPDCADIKEASQPFSLGPRACLGRN (2)
VAYMEINLILARLIWTYDMELVNKSMDWESESSLHVMWSKPELKVRFRQARP*
CYP567D2 Aspergillus oryzae
GenEMBL BAE64652.1, AP007171.1
99% to CYP567D2 Aspergillus flavus
59% to 567D1, some errors
14 P450 genes and 2 pseudogenes on this contig
MDRVVWLGLAVA (0)
286366 LTALYWVHLVIYNVFFHPLASFPGPFWARASF (0)
IWRMWHTSTGRVHRAIEFQHNLH (1)
GDIVRISPNELSFASVESWKAIYQPKSAPLVKSEFYEIYGSGFNSLCIGSE
RNPETHSRMRKSLAAAFSTKALLEQEDIIQGCVNDFIEGIRSQTTVNFTKWFEMLAFDILGEMAFGESFHCIEN (1)
SKSHFWCDMIEEHLYFITILDNLRRYPLIAAIGKTILPHLTVSVRNKHTNYSRRKVA
HRLQSSSPRADFMSRLIAKVEDEEMEMEELTAHASTLV
IAGGETVATFLAAVTYHLLSTPN
AYQKLRDEIRARYNHLSEITSTTALQLPYLQAVISEGLRIYPPGSQGFPRNTPPQGIVVKGTYVPGNVEV
YTSAWTVTHDARYFHDPYTFKPERWLDPNCTDNKDASQPFSLGPRGCLGRNFAIVEMSLILCKLHFQFDA
ELVNPFQEWESASQLHVMWWKPDLPVRFIPCTRDH
CYP567D2 Aspergillus flavus
AAIH02000253.1
Gene model revised
MDRVVWLGLAVA(0)
LTALYWIHLAIYNVFFHPLASFPGPFWARASF (0)
IWRMWHTSTGRVHRAIEFQHKLH (1)
GDIVRISPNELSFASVESWKAIYQPKSAPLVKSEFYEIYGSGFNSLCIGSERNPETHSRMRKSLAAAFS
TKALLEQEDIIQGCVNDFIEGIRSQTTVNVTKWFEMLAFDILGEMAFGESFHCIEN (1)
SKSHFWCDMIEEHLYFITILDNLRRYPLIAA
IGKTILPHLTVSVRNKHTNYSRR
KVAHRLQSSSPRADFMSRLIAKVEDEEMEMEELTAHASTLV
IAGGETVATFLAAVTYHLLSTPNAYQKLRDEIRARYNHLSEITSTTALQL
PYLQAVISEGLRIYPPGSQGFPRNTPPQGIVVKGTYVPGN
VEVYTSAWTVTHDARYFHDPYTFKPERWLDPNCTDNKDASQPFSLGPRGCLGRN
FAIVEMSLILCKLHFQFDAELVNPFQEWESASQLHVMWWKPDLPVRFIPCTRDH*
CYP567D3 Aspergillus clavatus NRRL 1
XM_001273850.1
89% to A. nidulans CYP567D1
MSASWGYEPTSWLDIFTVVFVL (0)
ERHANGTELQILVYVSTQSLYNIYFHPLAGFPGPLVARASL (0)
AWRIYHSMGGRFHRAIDEQHRRYGPVFRVSPNELSFASVASWKDIYCHRATGQLPLIKSKFYDIY
GAGFGSLCIGSERDPDKHTRMKKSLSPAFSLRSLGDQEAILSQCVDRFVSRMGEPELN
AGGLNMTKWYEMVAFDILGELSFGESFHSIEDGKPHFWSSLVKDHLYFITVADNLRHF
PVVALIAKLLSPFLNGIRKKHTGYTRDKAARRIGSSSARKDFMANLIGKLESNEMDRE
ELTAHASTLVIAGGETVATFLAATTFYLLRNDAAYQNLKAEIRGQFNTYAEITSARAQ
ALPYLQAVISEGLRIYPPGSQGFPRVSPGASIDGIWVPAGAEVYTSAWTVTHNEANFH
DPHTFKPERWIDPDCADIKEASQPFSLGTQACLGRNVAYMEINLILARLIWMYDMETV
NKSMDWESESSLHVMWSKPDLKVHFRQARP
CYP567D4 Penicillum citrinum
BD294644 patent seq
7438-9250 between orf19 and orf17
50% to CYP567D3 (possible ortholog)
MDTWGGIGWVNYSGI
7432 VLIYITVTVIYNLYLHPLSGFPGPFWARSSLVCAVPNQLQDPVL
7580 MENLPFYGWSISPRHRPTTQKIRSGPSICTGPELY 7684
RARVVLTTTAGHVVRISPNELSFASVESWKAIYGHQVSGK 7788
7789 PVPIKSQFYEIYGAGFTSLCIGSERDPKKHGRMRKLLSAAFATKSLVEQEVIVAQAIDLF 7968
7969 IDQLGRKGGPETSGLDLTKWYEMAAFDILGEMAFGESFNCIKS 8097
8185 DHLYFITLIDNLRRIPLLVRITRLLFPSNLAVRNRNSEYSRGQVA 8319
8373 LTRRLSKPTARKDFLTTMVKHFEDGNLEKEELTAHVSTLVYA 8498
8559 TTFRIAGGETIATFLGAVTYHLLQSQVCHEKLKNEIRGHFAKSEDINATEARKLPYLQAV 8738
8739 IDEGLRIYPPGSQGFPRVSTGMLIGSTWVPPGVCTPIPHLAVSHE 8873
8897 EIYTSAWTVTHSEEYFSEPMKFKPDRWLDQGSTDVKEASQPFSLGPRGCLGQ 9052
9107 SFAMMEINLILAKMFWRYDLELLDPNLDWEGQSHMHVMWWKPELPVRFFERQA* 9268
CYP567E1 Aspergillus nidulans
AN3275.1
53 clan
revised 7/19/07
MVPYGTCETMDHFRGQPALVLIGASALVGIITWIARLLIRAFVSHPLAHFPGPRLSALSN (0)
LNYSWSYMGGRQPYDILNLHAEY (1)
GSVVRVAPNELSFNTAQSWKDIYAPRKGRATFIKSDFYDGGNFADQASSI
VSERDPARHSAMRKFLSAAFSDRSLREQEGLVTRVIDDFIDQVGQRGNSKDGVDMTMWTNL
LTFDIIGEL (1)
AVVLESMGQAGLSDFLKRFPIIGRVFLKLNPRWLNKLMDGAIKHQTYTIDLVKR (2)
RIQQKTNRKDFMSYLLLERNSSQISDIQLAAHASDFV (2)
ATLKEDHSIAGSETTATCLATVIYYVGRNPRILKTLQEEVRSAFRNYEEI
NGQSTSSLKYLHAVCLEALRIFPPLALALPRVVPEGGEMIDGHFVPEK (0)
TIVSTNPLAASMDPANFDTPWAFCPERWIRLSEKDQLEASQPFSMGSRSCLGRG (2)
LAWLELRLTLAKLYYRYDLKLVDDELDWHRDAAMHLLWVKPKLMTQVLPRAK*
CYP567E2 Aspergillus clavatus NRRL 1
XM_001273844.1, revised
1 MDQFKGQPAWVLIGVSGLMGIMIWIARLLIQAFVSHPLAHFPGPRLSALSNLNYSWAYMG 180
181 GRQPYDILNLHAKYGPVVRVAPNELSFNTPQSWKDIYAPRKGRPTFIKSDFYDGGNFADQ 360
361 ASSVVSERDPAKHRAMRKFLAAAFSERSLREQEGLVTQVIDDFIDQVGQRGNSKEGVDMT 540
541 MWTNLLTFDIIGQL ()
AFGESFHGLETGNLHFWIAVVTESMGQAGLSDFLKRFPIIGHIFLK 720
721 LNPRWLNKLMDGAIKHQTYTIDLVKRRIQQKTNRKDFMSHLLAERNASQISDIQLAAHAS 900
901 DFVIAGSETTATCLATVIYYVGRNPRILKALQEEVRSAFGRPEEINGQSTSS 1056
1057 LKYLHAVCLEALRIFPPLALGLPRVVPEGGEMIDGYFVPAKTIVSTNPFAASLDPANFDA 1236
1237 PWVFCPERWLRLSAEDQLEASQPFSMGSRSCLGQGLAWLELRLTLAKLYYWYDLKLVDDE 1416
1417 LEWHGDVAMHLLWVKPKLMTQVTPRAK* 1500
CYP567E3 Penicillium citrinum
BD294642 PAT 04-NOV-2005
DNAs related to the biosynthesis of ML-236B (compactin)
MEGFGSFLGIAMPLLVAFILKLGIWRVYFDQLSKFPGPGLSALTNVPYSMSYLSGRQPWE
MLSLHKKYGSVVRVSPTELSFSTAQSWRDIYGTQRGRAGFIKSSFYDGGNFADKAHSIVS
ERDPEKHSAMRRFLSTAFSDRSLREQEGLITSTIDKFVQKVGEVGSHPQGVDLTNWFNLL
TFDIIGDLAFGESFGGSLYIGKTHPWISVVLESMGQASLSDTIQRFPWMGRLYMRLNPEW
ARRLIAGSIKHESNTMDLVKRRIASKSPRSDFMSYLLRERSEFDQEVSDTQLAAHASDFV
IAGSETTATTLLVVAYYLSRYPEITRKLQKEVRSAFDSYEEINGSSTARLRYLHVICLEA
MRMVPPLPLGLPRVVPKGGAMVDGHFVIVSTNPLAASLDPKNFENPWTFDPDRWLQDGKE
QFGEASQPFSLGSRSCLGRSLAWLEMRVTLAKLHFSYDFTPVNENIDLQQDLRMHLLWKK
PELRFRVSPRK
CYP567E4 Podospora anserina DSM 980
NW_001914833 XM_001903508.1
join(290518..290576,290629..290705,290761..291144,
291257..291437,291504..291975)
P450 adjacent to terpene cyclase
49% to 567E1
MSTSIPFPSSLVPCTAPLVTQQIPHCLWFLGGRQPYKILELHNR
YGPVVRTAPNDLSFNTAQSWKDIYGSRQGHQAFVKSAFYDGGSFASRGVGSIVSERNV
DAHAQMRRYLSHAFSDRSLAEQEDIIARTMDIWVESLLKKGSRKEGIEMGKSFRIMTF
DIIGELAFGENFK (1)
ALNQGALADTLKRFPTLAWLAQGLLQKKIWELT
EDTKKNENFAIDMINRRIHRDELSRKDFMTHILQRRGSAQVSDLQLAAHASDFALAGS
ETTGTALSAIMYYLLRTPQVMLKLQKEIRGSFKTYSEICFRSTIGLPYLDAVILEGLR
MYPPVPLGLPRVVPDGGDTVDGHFLPAGS VVVYTHPVAASLSSANFKDPQAFKPDRWLDEHQGDIREASQ (0)
PFSLGTRACMGRKY (0)
MRTALAKVLWKYDLELVNTSLDWHRDSEMHTLWCKPALW
VRLRVLKE*
CYP567F1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_19000024
Necha1/scaffold_19:59238-60876
47% to 567B1
See fungal pages for seq
CYP567F2 Fusarium oxysporum
59% to 567F1
See fungal pages for seq
CYP567F2 Fusarium verticillioides
92% to CYP567F2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP567F3 Fusarium oxysporum
59% to CYP576F1
See fungal pages for seq
CYP567G1 Phaeosphaeria nodorum SN15
XM_001795181.1
102355-104120
45% to CYP567E1
102355 MMITALSWFSAYSVQTL
102406 SLCALIVFVANKVWKHLRHPLREFPGPRLAAWTDIPYCYWLLGGRQPFVLLQLHEKYGP 582
583 VVRIAPNELSFNTAASWKDIYGYRPGHRTFVKGEFYDGAAFVKSHATRSLINTKDPTEHG 762
763 KMRRYLANAFSDKSLREQESLVAQEVDKLVEKLGEAGLAKDGTDLQRWLNMATFDITGSLSF (1) 945
EQTTDDPQMARHPTV
AFILRAILTLSFVDTVRRFPWLDT
VARIAMPGRIK (1)
AQLHHASTKRQ
1267 LTVPERRIDKPSNRPDILTRIIDKKDEAGISDIQIAAHAADLL (2)
TMLTFHRTAGSDS 1446
1447 TNTAMGTVFYYLLKRSDIMQRLQAEIRSSVESYNEITALSTNNLPFLIAVIREAMRIYPP 1626
1627 VPLALPRIVPEGGDTIDGRFVPAG (0)
TGVSTHPFAACLDAKNFEDP 1806
1807 WIFRPERWLGKSEQNVREASQPFSLGTRGCIGQ 1905
1959 LAWIEMRTIVAKVIYAYDLKWLNPVMDWHRESQMHILWHKPQLMVRVVARQRT* 104120
CYP567H1 Metarhizium anisopliae var. anisopliae Ma23
CYP568A1 Magnaporthe grisea
MG07507.4 poor match AACU01000909 cont2.1395
See fungal pages for seq
CYP570A1 Magnaporthe grisea
MG03392.4 40% to CYP527A1 39% to 527C1
AACU01000700 cont2.665
See fungal pages for seq
CYP570A2 Metarhizium anisopliae var. acridum Ma102
CYP570A2 Metarhizium anisopliae var. anisopliae Ma23
CYP570A3 Grosmannia clavigera
CYP570B1 Magnaporthe grisea
MG01544.4 40% to 527C1, 40% to 535A1
AACU01000068 cont2.284
See fungal pages for seq
CYP570B2 Grosmannia clavigera
CYP570C1 Fusarium graminearum
AACM01000122.1 added C-term gc boundary after YVE
See fungal pages for seq
CYP570C2 Fusarium graminearum
FG02929.1 AACM01000143 FGcontig1.143_scaffold2
See fungal pages for seq
CYP570C3 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.7.150.1
Necha1/scaffold_7:1454491-1456289
86% to 570C1 probable ortholog
See fungal pages for seq
CYP570C4 Fusarium oxysporum
84% to CYP570C2
FOXG_14304 Supercontig 24: 19205-19551 (-) strand same seq
FOXG_14867 Supercontig_25: 302853-303199 (-) strand
FOXG_14868 Supercontig 25: 303463-304548 (-) strand
Supercontig_25 302737-304548, joined the two models above
See fungal pages for seq
CYP570C5P Fusarium oxysporum
Supercontig_23 457233-458956 (-) strand
Not found in Fungal genome database
One stop codon, possible pseudogene
See fungal pages for seq
CYP570C5P Fusarium verticillioides
99% to CYP570C5 Fusarium oxysporum = ortholog, only 1 aa diff
both species have stop codons in the same
place, both are in ther EXXR motif
See fungal pages for seq
CYP570C6 Fusarium oxysporum
Supercontig_2 5000713-5002479 (+) strand
Not found in Fungal genome database
See fungal pages for seq
CYP570C7 Fusarium oxysporum
Supercontig_13
88% to 570C1
See fungal pages for seq
CYP570C7 Fusarium verticillioides
90% to CYP570C7 Fusarium oxysporum = ortholog
Note: possible mutation TGA to CGA at normal stop codon extends gene
Also one frameshift = & in first exon, possible pseudogene
See fungal pages for seq
CYP570C8 Metarhizium anisopliae var. acridum Ma102
CYP570C8 Metarhizium anisopliae var. anisopliae Ma23
CYP570D1 Fusarium graminearum
AACM01000470.1
See fungal pages for seq
CYP570D2P Nectria haematococca (Fusarium solani group)
JGI gene model gw1.28.270.1
Necha1/scaffold_28:406101-407808
67% to 570D1 probable ortholog
See fungal pages for seq
CYP570D3 Nectria haematococca
JGI gene model fgenesh1_pg.sca_33_chr6_1_0000031|Necha2
97% TO 570D2P W/O Stops
MSAGQGLSPGLLREAFVALSPGTVILTAVIGLVVLFLADSLRTWYRLSHVPGPFWAGFSKAWMVRQSLKGTQPYAIQAAN
EKYGSLVRIGPNELATDDPKLLRRMMASRSPYSRGPWYNALRFEPGKDNLFSMRDDDAHAKLRNKMAAGYSGKENESLER
TVDTHIARLVDLIETKYLSTSRDYRPTDFAQKIQYFTLDVISDLAFGQPFGYVDQDDDVFDFIKITRSFFPVTLVIANIP
SLVSLLHSRLFRGLLPKESDKFGFGAFIGVANKKVAERFAPNATQHSDMLGSFIRHGLTQEEASRESLLNVVAGSDTSAT
TIRVIMLSLLSNPVAYRNLQKEIDDAIKAGKISSPVTDAEARKLPYLQAAIQEGLRMKAPAAGPLFKTVPKQGDTIDGKF
IPGGTQIGTSPFSIYHSKKIFGNDAALFVPERWLEAEPEQVEGMSEVVNLVFSSGKYQCLGKPVALMELNKIFVELLRRF
DFAMVRPERPLHIMNAGIWLIEDFPLRISRRDSSPDA*
CYP570D4 Fusarium oxysporum
82% to CYP570D3
See fungal pages for seq
CYP570D4 Fusarium verticillioides
94% to CYP570D4 Fusarium oxysporum
See fungal pages for seq
CYP570E1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.4.199.1
Necha1/scaffold_4:1300784-1302553
42% to 570D1
See fungal pages for seq
CYP570E2 Fusarium oxysporum
78% to CYP570E1 Nectria haematococca
See fungal pages for seq
CYP570E2 Fusarium verticillioides
93% to CYP570E2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP570F1 Mycosphaerella graminicola
42% to CYP570C1, 41% to 570D1,
41% to 570B1, (borderline member of CYP570)
See fungal pages for seq
CYP570G1 Mycosphaerella graminicola
42% to 570C3, 39% to 570D3, 41% to 570A1, 39% to 527D1
The two families CYP570 and CYP527 may have some overlap
See fungal pages for seq
CYP570G2 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_260099
71% to CYP570G1 Mycosphaerella graminicola
See fungal pages for seq
CYP570H1 Mycosphaerella graminicola
44% to CYP570C1 new N-term from JGI model
fgenesh1_pg.C_chr_1001460|Mycgr3
See fungal pages for seq
CYP570J1 Histoplasma capsulatum G217B
48% to CYP570A1 Magnaporthe grisea
See fungal pages for seq
CYP570K1 Aspergillus clavatus
49% to CYP570C1 Fusarium graminearum, 47% to CYP570D3 Nectria
See fungal pages for seq
CYP570L1P Mycosphaerella fijiensis
JGI gene model e_gw1.17.140.1
40% to CYP570F1 Mycosphaerella graminicola
See fungal pages for seq
CYP571A1X name changed to CYP535A1
CYP572A1 Magnaporthe grisea
MG04345.4 poor match AACU01001098 cont2.822
See fungal pages for seq
CYP573A1 Magnaporthe grisea
MG05215.4 poor match AACU01000797 cont2.962
See fungal pages for seq
CYP573A2 Fusarium graminearum
FG03008.1 AACM01000145
FGcontig1.145_scaffold2, C-term revised
See fungal pages for seq
CYP573A3 Aspergillus nidulans
AN7773.1 57% to 573A2 53 clan
See fungal pages for seq
CYP573A4 Nectria haematococca (Fusarium solani group)
JGI gen model e_gw1.23.293.1
Necha1/scaffold_23:206165-207796
78% to 573A2 probable ortholog
See fungal pages for seq
CYP573A5 Aspergillus oryzae
GenEMBL AP007157.1a (first P450 of 8 on this accession)
BAE58632.1
75% to 573A3 probable ortholog
79% to CYP573A6 Aspergillus fumigatus
complement(join(116142..116234,116333..117206,
117277..117401,117462..117649,117710..117944))
revised 3/17/2009
Supercontig 8: 116142-117944 (-) strand
MVLAGEDLVAMFTVTHVILALGAYVALRFAYQIVYYRFFHPLSVFPG
PFWGSVTRLWIAWHNLRETEVPTVYALTKKY (1)
GPVVRITPTLLLVSDPTKLPDIYHRNA ()
DKTGHYITGSFGETESLFNIRSHKTHAAFRKHIAGP (0)
YSFSNVTRMEPLVDARIDDWLNKLDETFASTGAKFDFAWWAV ()
YVAYDVISEIGFGAPFGFIEQGKDVGGLIQGFHDGLPAFGLLARLHPFTSWMKTTFMKKY
LVAKPEDNTGIGVLMRFRDRLIEQRLREIAEGKDVGRVDLLQTFIDARTEDGKPLDMDYL
KAEVLLVLLAGADTTGTVFQSLVNHLLVNQEVYERMMEEIDTASRKGLIPETIPQYDAIQ
EHLPYYVACVRETLRLNPPAPNIFPRYVSEPGIELFGKFAPAGTEVTGNPWIMHRDTALF
GEDAEEFRPERWLDPEKAKLYNKYIFTFGYGTRVCLGRDIAMEELFKGPLQ (0)
FFRRYTPSIATDKPSARFEVKGGIGYWRDMWVSINRRPAVKPL*
CYP573A5 Aspergillus flavus
99% to CYP573A5 Aspergillus oryzae, only 1 aa diff
Note: end is n a sequence gap
See fungal pages for seq
CYP573A6 Aspergillus fumigatus Af293
XP_748848.1 also EAL86810.1
68% to 573A3 95% to CYP573A6 Neosartorya fischeri
revised 3/12/2009
MGLREEILARLTLSHVVLGLVAYVLLKFVYQIVYYHFFHPLSVFPGPFWGGVTRLWIAWHNLRETELPTVYALTKKY (1)
GPVVRITPTLLLVSDPTKLPDIYHRNADKTGHYITGSFGETESLFNMRSHKTHAAFRKHLAGP (0)
YSFTNVKKMEPLVDIRIQHWIDKLNEKFAQTGEIFDFSWWAVYMAYDIISEIGFGAPFGFVEQGQDVGGLIQGFHD
LPAF
GLLARLHPFTSWMKTTFMKKYLVATPQDDSGIGVLMRFRDRLIDQRFRELETKKDIGRIDLLQTFIEART
EDGSPLDMEYLKAEVLLVLLAGADTTGTVFQALVHFLLTHRDAYRRLMEEIDAATAQGLISDPVPQYDEI
VEHLPYYVACVRETLRLNPPAPNIFPRYVSEPGMDLYGKFAPAGTEISGNPWIMQRDKKLYGEDAEEFKP
ERWLDAERAKRYNKYSFTFGYGARVCLGRDIAMMELYKGPLQ ()
FFRRYHVQTVTDKPKARFVIKGGVGFYRDVWVTIDRRLPQKA
CYP573A6 Neosartorya fischeri
95% to CYP573A6 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP573A7 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_11000284|Aspni1
77% to CYP573A3
See fungal pages for seq
CYP573A8 Fusarium oxysporum
86% to CYP573A2 Fusarium graminearum
See fungal pages for seq
CYP573A8 Fusarium verticillioides
97% to CYP573A8 Fusarium oxysporum
See fungal pages for seq
CYP573A9 Aspergillus clavatus
76% to CYP573A3
See fungal pages for seq
CYP573A10 Aspergillus terreus
78% to CYP573A5
See fungal pages for seq
CYP573B1 Mycosphaerella graminicola
42% to CYP573A7 A. niger, 43% TO 573A2
See fungal pages for seq
CYP574A1 Magnaporthe grisea
MG05854.4 poor match AACU01000833 cont2.1101
See fungal pages for seq
CYP574B1 Grosmannia clavigera
CYP575A1 Magnaporthe grisea
MG10343.4 poor match AACU01001708 cont2.1991\
See fungal pages for seq
CYP576A1 Magnaporthe grisea
MG09057.4 69% to CYP576A2 AACU02000558
See fungal pages for seq
CYP576A2 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000365.1
69% to 576A1
43011 MYIFIIYILFVAIAASQVFKRIKAFRSPLREVPGPWYAPLTTLHLQYLFSTGNIWK 42844
42843 YVEKGHKCYGPIMRVGPRQVWISDKDAMKQILVKQDLPKVAMYAEISRDRASPGLFGEI (2) 42667
42610 RHEPHRRLKRFLSPAFTVAYVDNLEVHFQKIVRDLLNKYQSKVVSSAASERGFETDFM 42437
42436 EDLHNVALDI (2) 42407
42357 MGECSFGKGFGQTNPESKGEDGVDERIWKSIPRSIFDGLSKRYQ (0) 42226
42155 TVYIKKLIRFFVMDIKFDWPAEMIA (0)
41990 TSGTERQDLLQHLLEQGKRPDTGVTMNTRDITDQMAEILLAGSETTSGTLACLFLEL 41826
41825 ARNPVVYNKLLESLPSASLADDIVSSKTVRTESQYEYLEACIKENLRLHPIASEMGRRT 41649
41648 GTEWVNLMGYDLPPHTVVSASYRALHLNEEYWPQAQRFWPERFLAKDKRGDAPAAD (2)
MDAYYPFSGGKHSCIGIN (2)
FAWSEMRIVA 41289
41288 ASILSRFRLFEVSNQEVDFRQYITMQFATGEWKVILEPRQVEMS* 41154
CYP576A3 Aspergillus terreus NIH2624
GenEMBL AAJN01000022.1
Possible AC boundary before RHDPH (intron 1)
60% to 576A2, 59% to 576A1
65914 MGRLVEQGIVHPYYSFILLIIFLLCVSYIIGVVKAIVSPLSRIPGPWYAPLTTLHLNYAFATGKIWKIVEKG
HQEYGSIMRLGPRQVWVSDMEAMRTILITADLPKVTMYAEISRDRSSPGLFGEI (2) 65537
65481 RHDPHKRLKRFLSPAFTVSYVDKLEPLFTECLKDLIVKYSDAFSSRRFETFTQPA
TMDLMDDLHSLALDI (2) 65272
65224 MGECSFGRGFGYTNPQKETTFGIDEKIWSGIPSAIFKGMAQRYQ (0) 65093
65040 MVYFKRLLRKIGVDIKFDWPDSMIA (0) 64960
64856 KNLGPDLLQHLIDEGEKPDSGMKMVPRDVIDQMSEVLLAGSETTSGTIGCFFLEVLRNPQVKARL 64677
64676 LEALPVLLPNDSIITSKAVRTDSQYEYLEACIKETLRLHPIASEMGRRTLNQSIELIGFS 64497
64496 IPPHTFVCASYRDLHRNPAYWPDPLRFWPERWLQNRPPDVP 64374
LTAYYPFSAGKHSCIGKN (2) 64250
64153 FAWAEIRMVTANLLSRFEFIEVPAQDIDYRQYITMQFANGSWKA FLKPRYESRAEFFTI* 63974
CYP576A4 Aspergillus niger
JGI gene model e_gw1.20.142.1|Aspni1
68% to CYP576A3
See fungal pages for seq
CYP576B1 Mycosphaerella graminicola
52% to 576A1
See fungal pages for seq
CYP577A1 Magnaporthe grisea
See fungal pages for seq
CYP577A2 Fusarium graminearum
AACM01000316.1
Gibberella zeae PH-1 revised (formerly 577B1)
See fungal pages for seq
CYP577A3 Nectria haematococca (Fusarium solani group)
JGI gene model estExt_Genewise1.C_270019
Necha1/scaffold_27:156564-158470
64% to 577A2 probable ortholog
See fungal pages for seq
CYP577A4 Aspergillus oryzae
GenEMBL AP007157.1g (seventh P450 of 8 on this accession)
BAE58995.1
53% to 577A2 probable ortholog
join(1148972..1150341,1150393..1150552)
1148972 MTITLVAIATGIVAFILYYICWSLFSSPLARIPGPKSFALTKWRLAYEDYKGTRTRKIHALHERY 1149166
1149167 GPVVRIGPNEVAFNSLSALRAIYGAGSGFERTNFYSMFAIYGRKNMFSFNTVKQHAERKK 1149346
1149347 LFAHAYAKSAMLKGINASMIETKVRKYMEFLEREGRSQDIFTTLHYFSLDNITEFLYGD 1149523
1149524 FGKTACLDGIEEDRALLHDILATGSRTLSWLTVHHPKLTAWLYSRTGFLGCVARQFYPMQ 1149703
1149704 RPTPYTSIKLHATKAFQGFADASVAEKAKQSSLISKLWKHHRSMKDGGLDNLDIASECAD 1149883
1149884 QLDGGIDTTSDTLMFTIWSLSRPEHWGFQQKLIDEVRSISEHDLNPEGIPRVEAADKLPY 1150063
1150064 VEAVIKETLRLFAPLPASEPRSSPEATTIDGYLIPARTVVSISPYTLHRNAEVFKNPLEF 1150243
1150244 NPDRWLDPSQDLTEMNRFFWAFSSGGRMCIGMH (2)
1150394 LAMAEMTTFVAALYRKYTTEPRGGFGTISPGITSRFEVFYDEGCSDMR (0) 1150537
EHQCQIEFKLQ*
CYP577A4 Aspergillus flavus
99% to CYP577A4 Aspergillus oryzae
See fungal pages for seq
CYP577A5 Gibberella moniliformis
GenEMBL AAIM01003330
GC boundary at CVGM
2400 MAILPIAAAVLAVVLFIKHIFLDPLILSPLRHVPGPKSFAATKWRLAYEDWKGTRTRTIF 2579
2580 KLHQLYGPVVRIGPHEVSFNSLSALRTIYGPGSRYGRTTFYRMFDVYGEQNLFTFHSPKE 2759
2760 HGDRKKLLSHAYSKSVVLKPPTAKMVERRVRQYLDLIEAEPENISEIFSTLHYYSLDNIT 2939
2940 AFVYGKYGQTAAIRGSKIHRELIADILHPSRRKLSWSIVHLKTLTQWLYRQSGLMGQLVK 3119
3120 PVLPMQQPTTYTGIRGYALRAFEAFRADVEKITHSE (1)
DEHVS 3293
3294 IVENLWQHHESQKPGGLRDLQMASECADHFLAGIDTTSDTLMFLVWALSLPGNEKYQEKL 3473
3474 REEVMAISGDGLNQWGNPRAEASDRCTYINAVIKETLRLYAPLPSTEPRSIDIDSVIDGY 3653
3654 SIPGNTVVGMSPWIMHRNEKVFKDPLVFNPDRWLGPDAAELNRWFWGFSSGGRMCVGM (2)3827
LAMAEMTTLTATMYRQFRTTIAPGFEDTTPAITARVETFYDDRFPK (0)
ESKCLIKFTKLKE*
CYP577A6 Mycosphaerella graminicola
55% to CYP577A3 Nectria haematococca
See fungal pages for seq
CYP577A7 Fusarium oxysporum
97% to CYP577A5 Gibberella moniliformis
See fungal pages for seq
CYP577A7 Fusarium verticillioides
98% to CYP577A7 Fusarium oxysporum
See fungal pages for seq
CYP577A8 Aspergillus clavatus
56% TO CYP577A2 Fusarium graminearum
See fungal pages for seq
CYP577A9 Aspergillus terreus
54% to CYP577A8
See fungal pages for seq
CYP577A10 Aspergillus terreus
70% to CYP577A8, 56% to CYP577A9
See fungal pages for seq
CYP577A11 Mycosphaerella fijiensis
JGI gene model e_gw1.6.418.1
59% to CYP577A6 Mgr082 Mycosphaerella graminicola
See fungal pages for seq
CYP577A12 Grosmannia clavigera
CYP578A1 Magnaporthe grisea
MG04605.4 poor match AACU01001135 cont2.866
See fungal pages for seq
CYP578A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.24.56.1
Necha1/scaffold_24:249201-250960
53% to 578A1 probable ortholog
See fungal pages for seq
CYP578A3 Fusarium oxysporum
64% to CYP578A1
See fungal pages for seq
CYP578A3 Fusarium verticillioides
92% to CYP578A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP578B1 Aspergillus nidulans
AN1087.2 AACD01000016
42% to 578A1 53 clan
AACD01000016.1 revised near heme signature
MFTHTAIFTLSFLLTVSFLLFIYLIHPLFLSRLSKLNIPNAHFTSPLSSY
WINSIRHAGLETVTIQALHAKHGPVVRLSPNELSVNSLHGLRVIYTGAFE
KHALYRDLFLNFHTENLVGMLGNKEHARQKRMLSRVYSKSYLQESEDMRV
ISAVILSTRLLPILQRIAENGETVNVLPLFQAVGMDFTSAYLLGVQNGTS
FLFDLPGWQRWLEEYEKFKHLSLNERADGFIERWCLDLCRQTQTESSSSD
AISTKPVVYNALRHGLEKSPDSRPSDLAIASELLDHLIAGHETSGITFTY
MMWELSHCPNLQDELRAELLLLQPSLKYPFPSGGGNGSFPHPSSVDNLPL
LDAIVRETLRLHAPASSPLPRVTPDTPGGTSIDGFDGIPGGITVSSSAYT
LHRIEEVYPQPTEWLPQRWLDPGSGKKHDMRRLWWPFGSGGRMCLGSNFALQ (1)
EIKLVTAAVYTNYTTAVVDDEGIEQDLADFISLPKGRKLVLRFDPINRA*
CYP578B2 Aspergillus fumigatus Af293
GenEMBL XP_748713.1 also EAL86675.1
65% to 578B1
MFLLTIVAVSSFLVLLLYKILISPYFLSPLSKIPNAHFTAPISDYWIERKRRSGEEVLTIYNLHREHGPV
VRLGPNELSVNSLGGLHVIYTGAFEKHSFYRDTFVNFLTDNLVGMLPNDSHARQKRMLSKIYSKSYLHES
VDLRNASSIILSQRLLPVLKNAAEKGEAINVLPLFQAVGMDFTSAFLFGTANSTTFLFDLPGWKRWLVEY
ERFKTLSGKERYLGFIERWCLSLCSRVQSNEHPNDVPVATNPVVYSQLRQSLEKHPDQRPLDLALASELL
DHLVAGHETSGITFVYMMWELSKRPRLQAELRQELLTLSPSLRYPLVELGDGSLPLLPSPAAIDSLPLLD
AVVRETLRVHSPAPAPLPRITPSSSEGIAIEGYDRIPGGVKVSSSSYTLHRISEVYPQPFEWLPERWLDP
GPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYSNYTTSIVDDEGIEQDYAFISLPKGRKLML
KFTPVKL
CYP578B2 Neosartorya fischeri NRRL 181
DS027697, NFIA_006220
join(1665966..1667316,1667397..1667539)
94% to CYP578B2 Aspergillus fumigatus = ortholog, 66% to 578B1
name revised from CYP578B4
See fungal pages for seq
MFLLTIVAVSSFLVLLLYKFLICPYFLSPLSKIPNAHFTAPISD
YWIERKRRSGEEVLTIYDLHREHGPVVRLGPNELSVNSLGGLHVIYTGAFEKHSFYRD
AFVNFLTDNLVGMLPNGSHARQKRMLSKIYSKSYLHESVDLRNISSIILSQRLLPILK
RVAEKGEAINVLPLFQAVGMDFTSAFLFGTANSTTFLFDLPGWERWLVEYERFKYLSV
KERYLGFIESWCLSLCSRMQSNEHPNDVPVATNPVVYSQLRQSLEKHPDQRPLDLALA
SELLDHLVAGHETSGITFVYMMWELSKRPQLQAKLRQELLTLSPSLRYPFVELSNDSL
PLLPSPAAIDSLPLLDAIVRETLRVHSPAPAPLPRVTPSSPEGIAIEGYDRIPGGVKV
SSSSYTLHRISGVYPQPFEWLPERWLDPGPGKIHDMRRLFWPFGSGGRMCLGSNFALQ
EIKLVMAAVYTNYTTSIVDDEGIEQDYAFISLPKGRKLMLRFTPVKL
CYP578B3 Aspergillus oryzae
GenEMBL BAE66519.1
62% to 578B1
MTSATAIAIGILLAAFVYKYLVHPYCLSPISSVPNAHFTSPISNRWIEKQRNAGKEVLTIYNLHQKLGPV
VRLGPDELSVNSLSGLKTIYTGAFEKHSFYSDVFINFQTPNLVGMIHNNPHARQKRMLSRIYSKSYLQES
RDLRDISKIILSQRLFPILRRVAKSGEAINVLPLFQAVGMDFTSSYLFGTKNSTTYIFHLPEWQQWLEEY
EKFKYMSVQDRYMGFIESWCLSLCRKVENNDQPNDVPIATNAVVYNQLRQSLEKDPDSRPLELAIASEVL
DHLVAGHETSGITFTYMMWELSQHPELQAELRRELLTLTPNLRSLPISDNAVDLPSLPSPSAIDALPLLD
AVLRETLRLHSPAPAPLPRVTPASPTGVSIEGYHNLPAGVRVSSSSYSLHRIEEVYPQSSDWLPERWLKP
EPGKIHDMRRLFWPFGSGGRMCLGSNFALQEIKLVMAAVYTNFTTSIVDDEGIEQDHAFISLPTGRKLML
RFTPIKEA
CYP578B3 Aspergillus flavus
100% to CYP578B3 Aspergillus oryzae
See fungal pages for seq
CYP578B5 Aspergillus niger
JGI gene model e_gw1.3.1489.1|Aspni1
56% to CYP578B3
See fungal pages for seq
CYP578B6 Aspergillus clavatus
75% to CYP578B2
See fungal pages for seq
CYP578B7 Aspergillus terreus
70% to 578B3
See fungal pages for seq
CYP578C1 Aspergillus nidulans
AACD01000007, AN0459.2 revised 7/18/07
MEVPVFAWIVPIMLGLTLLYEFVIYPAFLSPLSKLPNAHWTAPISPAWILWKRFRGQNNRT
IHAAHERLGSIVRLAPSEISINCVDGGIKSVYTGGFDKHEWYPRVFGSFG (2)
TVSMFT
MTGSKAHSTRKRMLSNIYSKSYLQSSRHLQLISKTIIFDRLLPILQAAAS
SKTDTDVHDLNQGLTMDFVSAYLFGLANGTNFLQNAEYRREMLRLYQCRK
PYEFYHQEVPNILALLKKIGIRLIPKWCDDANRILDSWGLELCDKAEASV
ASSDLSVEPVVYKHLKQAISKQAPLKIDDQKLYADYLEQQRLDIACEMYD
HLTAGHETSAVVLTYLMWELSQHIEVQKDLHKELLTLQPRIAPRCLSGHA
ELPSPKSIDSLPFLEAILTETLRLHASIPGIQPRVTP
TPTCTLVGYDNIPPNTRVNAQAYSLHRNPEVFPDPETWEPKRWL
KDCNKPSELEERKRWFWAFGSGGRMCVGSNLALQ
KMKLVIAAIYTNFRTTIVNDDGIEAIDAYTVKPKGEKLILRFEYI*
CYP578C2 Aspergillus oryzae RIB40
GenEMBL AP007155
71% to 578C1
not predicted in Genbank protein section
MAGSPIVAISAIVLTITLLYKCIVYPVFLSPLSKIPNAHWTAPISPAWMLWKRFRSQNNR
TIQAAHERLGPIVRLSPSEISINCVEGGIKTVYTGGFEKHEWYPRVFGSLG (2)
TVSMFTMISSKPHSVRKRMLSNIYSKSYLQSSPHMRLISESILFDRLLPIIQEAVSSD
APIEVHDLNQGLTIDFVSAYLFGLANGTNWLQDAPFRRRMLHYYQGRKPYEFYHQEVPNL
VSWTKSLGIRLIPRWCDEANEMLDAWCLDLCDKAEQCLQSTEVSVEPVVYKQLQQAMIKQ
SSQKENTDESLKQQRLDIACELYDQLTAGFETSAVALTYLFWELSRHPDVQEELRA
ELLTLEPKILFPRSSASRGLPQAKAVDSLPLLEAIVTETLRLHAPIPGIQPRVTPYPSC
TLAGYSDIPANIRVNAQAYSLHRNPDVYPDPETWQPKRWLKGVNSDSDLEERRRWFWAFG
SGGRMCVGSNLALQ (1)
EIKLVTAAIYSNYRTSIVDDDNIEPIDAYTVKPRGDKLVLKFEAA*
>CYP578C2 Aspergillus flavus NRRL3357
AAIH01000684.1 100% TO A. oryzae
1413 MAGSPIVAISAIVLTITLLYKCIVYPVFLSPLSKIPNAHWTAPISPAWMLWKRFRSQNNR 1592
1593 TIQAAHERLGPIVRLSPSEISINCVEGGIKTVYTGGFEKHEWYPRVFGSLG (2) 1745
1816 TVSMFTMISSKPHSVRKRMLSNIYSKSYLQSSPHMRLISESILFDRLLPIIQEAVSSDAP 1995
1996 IEVHDLNQGLTIDFVSAYLFGLANGTNWLQDAPFRRRMLHYYQGRKPYEFYHQEVPNLVS 2175
2176 WTKSLGIRLIPRWCDEANEMLDAWCLDLCDKAEQCLQSTEVSVEPVVYKQLQQAMIKQSS 2355
2356 QKENTDESLKQQRLDIACELYDQLTAGFETSAVALTYLFWELSRHPDVQEELRAELLTLE 2535
2536 PKILFPRSSASRGLPQAKAVDSLPLLEAIVTETLRLHAPIPGIQPRVTPYPSCTLAGYSD 2715
2716 IPANIRVNAQAYSLHRNPDVYPDPETWQPKRWLKGVNSDSDLEERRRWFWAFGSGGRMCV 2895
2896 GSNLALQ (1) 2916
2975 EIKLVTAAIYSNYRTSIVDDDNIEPIDAYTVKPRGDKLVLKFEAA* 3112
CYP578C3 Aspergillus fumigatus Af293
GenEMBL AAHF01000007.1
74% to 578C1, 43% to CYP578D1, 46% to 578A2
1250155 MVVSIYTSLSIVILLLFVAYKAIVYPVFLSPLAKIPNAHWSAPVSPAWILWKRFRSQNNSTIHAAHE 1250355
1250356 RLGPIVRLGPSEISINCVEGGIKTVYSGGFEKHEWYPRVFGSFG (2)
1250548 TVSMFTMTGSKDHSVRKRMLSNIYSKSFLQSSPHMRLISRTIVYDRLLPILYDAAT 1250715
1250716 SSRPVDVHDLNQGLTMDFVSAYLYGVTNGTNFLQDAPYRQRMLHLYQSRKPFEFYHQEVP 1250895
1250896 NLLSWTKSLGIRLIPRYCDQANEILDSWGLGLCDKAEESLKSNRLEDEPAVYKHLKQM 1251069
1251070 ILKHLPENKNDVEYARILEQQRLDIACEMYDHLTAGHETSAVALTYLLWELSKRPELQDA 1251249
1251250 LRAELSTLEPMVIFPRPSESAELPPAKSIDSLPLLEAIVTETLRLHAPIPGIQPRVTPY 1251426
1251427 PSCTLAGYNNIPPKTRVNAQAYSLHRNPEVFPDPETWEPKRWLKDVNTPSELEERRRWFW 1251606
1251607 AFGSGGRMCVGSNLALQEMKLVVAAVYTNFKTSIVSDDNMEAIDAYTVKPTGESLILRFELVE* 1251848
CYP578C3 Neosartorya fischeri
96% to CYP578C3 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP578C4 Aspergillus terreus NIH2624
GenEMBL AAJN01000108.1
58% to 578C1, 34% to CYP578-un1
MAVSAFTVVALVSLGLFVLYRVIIHPAFI
17000 SPLSKIPNAHWTAPVSPVWILWKRYTSQNNRTIQAAHEKHGPIVRLSPNEISINCVENGI 16821
16820 KSVYTGGFEKHDWYPLGFGSL (1)
GHRTVSMFTMTGSKPHSTRKRM 16641
16640 MSNIYSKSFLQSSPHMRLISENIVFSRLLPIFQDAASSGKHLEMHDINQGVTMDFVSAYL 16461
16460 FGLANGTRFLQDEAYRKKMLHLYHSRKPFEFFNQEVPNLLSWTKALGIRLIPRWCDDA 16287
16286 NDILDRWNLELCDKAEASVGSTELDAEPVVYKQLKQAMLKHTSKEDNQNS 16137
16136 VPDTPEKQRIEIACELYDQLTAGFETSAVALTYLFWELSQHPELQTKLREELLTLDPSIR 15957
15956 YPATSKILPSAKSVDSLPLLDAIVTETLRLHAPIPGIQPRVTPYPSCNLAGYTGIP 15789
15788 ANTRVNAQAYSLHRNPEVFPEPETWQPERWLKDGNSSAELEERKRWFWAFGSGGRMCVGS 15609
15608 NLALQ (1)
EIKLVIASVFTNYRTSIVDDDGIEAIDAYTVKPRSEKLVLKIEVA*
CYP578C5 Aspergillus clavatus NRRL 1
NZ_AAKD03000006.1, 80% to 578C3
415154 MGVSTVTSLSIVSVFLFIAYKTIIYPAFLSPLSKIPNAHWSASVSPAWILWKRFRSQNNR 415333
415334 TIQAAHERLGPIVRLSPSEISVNCVEGGIKTIYTGGFEKHDWYPRVFGSFG (2) 415486
415548 TVSMFTMTGSKDHSVRKRMISNIYSKSFLQSSPHMRIISKTMIYDRLLPILYEAATSDTP 415727
415728 VDVHDLNQGLTMDFVSAYLYGLKNATNFLQDTSYRQRMIYLYQCRKPFEFYHQEVPNLIS 415907
415908 WAKSVGIRLIPRWCDQANEILDTWALGLCDKAEACLSSTKLEDEPTVYRQLRQTISKQLP 416087
416088 AKDDPESYAQNPKQQRLEIACELYDHLTAGHETSAVALTYLFWELSKHPELQKALREELS 416267
416268 TLDPKIVYPPPSASAELPSAKSIDSLPLLEAIVTETLRLHAPIPGIQPRVTPSPSCTLAG 416447
416448 YKDIPADTRVNAQAYSLHRNPEVFPEPENWEPKRWLKGINSPSELDERRRWFWAFGSGGR 416627
416628 MCVGSNLALQ (1) 416657
416708 EMKLTVAAIYTNFQTSVISDDNMEAIDAYTVKPRGEKLVLKFQTI* 416845
CYP578C6 Aspergillus niger
JGI gene model e_gw1.1.562.1|Aspni1
75% to CYP578C5
See fungal pages for seq
CYP578C7 Uncinocarpus reesii
61% to CYP578C2 Aspergillus oryzae
See fungal pages for seq
CYP578C8 Coccidioides immitis
78% to CYP578C7 Uncinocarpus reesii
See fungal pages for seq
CYP578C9P Histoplasma capsulatum G217B
pseudogene
ABBT01000030.1 Ajellomyces capsulatus G217B 99592-98639
51% to CYP578C7
See fungal pages for seq
CYP578D1 Nectria haematococca (Fusarium solani group)
JGI gene modle e_gw1.19.155.1
Necha1/scaffold_19:640595-642276
38% to 578A1 Magnaporthe grisea, 49% to 587E1
in CYP53 clan (part D)
See fungal pages for seq
CYP578D2 Fusarium oxysporum
87% to CYP578D1
See fungal pages for seq
CYP578E1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.53.20.1
Necha1/scaffold_53:74141-75808
48% to CYP578D1, 46% to CYP578C3, 39% to 578A2
in CYP53 clan (part D)
See fungal pages for seq
CYP578E2 Grosmannia clavigera
CYP578F1 Aspergillus niger
JGI gene model e_gw1.1.426.1|Aspni1
46% to CYP578C4
See fungal pages for seq
CYP578G1 Mycosphaerella graminicola
42% to CYP578C4 Aspergillus terreus, 43% to 578A2
See fungal pages for seq
CYP578G2 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pm.C_260019
54% to CYP578G1 Mgr041 Mycosphaerella graminicola
one frameshift = &, possible seq error
See fungal pages for seq
CYP578H1 Uncinocarpus reesii
38% to CYP578C3 Aspergillus fumigatus
See fungal pages for seq
CYP578H2 Coccidioides immitis
81% to CYP578H1 Uncinocarpus reesii
See fungal pages for seq
CYP578J1 Mycosphaerella fijiensis
JGI gene model gw1.9.589.1
39% to CYP578G1 Mycosphaerella graminicola
32/33 top hits are ALL CYP578 SEQS.
See fungal pages for seq
CYP578K1 Metarhizium anisopliae var. acridum Ma102
CYP578K1 Metarhizium anisopliae var. anisopliae Ma23
CYP578-un1 Aspergillus oryzae
BAE55033.1 AP007150.1
29% to 578C1, probable pseudogene, last exon may be wrong
MTQWIALLLVAICG
YLALRLRSSSLSKIPAAHWSARFSPIWILWKRYTGKELHTLVDAHQKHGSIVLVGPQD
LSVSCYQDGIRRVYDSGYPKPAPFYSMFNYYR ()
QQNAFTSLDRSEHGLRRRRTAALYSKSAL
1613568 MQSQHLRDITRSITYDRLLPKLNSVAQGNGRIDGLDLSYCICVDYLSSFIFGYSNGTNYLSQPKSAIDVW
RFHYENLMCQESFFVQETPSLYKLLRYISIDLLPRKYTESADFLGRWMSDMASKADRATDRKRSTGLPLA
LEDEPVVYDMAKEAVRKDSPHLSEGDQRKQVASEMFDHIC (?)
Missing I-helix motif here, 7aa
LVLGYAFWYLAQHPDAQQRIQTELNSQGID
MRSRETVTNSSKRPRAVELDSLPYLRAVIDECLRMRPTSTPLPRITPSNRKVSVAGIDGIPPGTRINTFQ 1614560
WFVHRDPQKWDNAHDWNPDRWLTRGNTDNKNEREDVLWAFAS
GPRMCLGNNWTYY (1?)
LTTLNSTAMQHILATICSSFNFTALPREENQCWPGSPEDELPIRVCLRN*
CYP578-un1 Aspergillus flavus
99% to CYP578-un1 Aspergillus oryzae
See fungal pages for seq
CYP579X name changed to CYP58
CYP580A1X name changed to CYP542B1
CYP581A1 Magnaporthe grisea
MG02094.4 poor match AACU01000401 cont2.392
See fungal pages for seq
CYP581A2 Gibberella moniliformis 7600
GenEMBL AAIM01003085.1
64% to 581A1
ERNVEKYVARSDPDMLTLLMQTGHF
77 SHQDLVEQTVHFFAAATETVAGSTCWAIHLLSRHPDIQDRLRAEIREHITSPRSDVSQSQ 256
257 LHSLKYLNAVTNEVLRYHSINTLLWREPTQDITLAGEPIPKGTKIVFSPWALNRDPA 427
428 HWGPDARLFNPSRWLDNPSGGADHAYSFLTFGGGPRRCVGEQYARDQLSCFVASLVG 598
599 RYKFTPVDLQNGSDEGREIGDDFALTLFKILSGWKLNVEVVPGW* 733
CYP581A3 Fusarium oxysporum
91% to CYP581A2
See fungal pages for seq
CYP581A3 Fusarium verticillioides
94% to CYP581A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP581A4P Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_12000008
45% to CYP581A1 Magnaporthe grisea
N-term not found
See fungal pages for seq
CYP582A1 Magnaporthe grisea
MG04911.4 poor match AACU01000762 cont2.921
See fungal pages for seq
CYP582B1 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000073.1
39% to 618A1, 41% to 582A1
198750 MYLETCAALSLAELCMLMLMHGVPSMYNVVCSYLVLFSLQYASINLYYTFIFPFY 198586
198585 VSSLRYMPGPKNHHFFIGHALNQFRANGPYELYLSWSRQWPTAPFIRYISFANTETLLVN 198406
198405 SLRAHQEVLSTKCYSFVKPPFFARIVGEVTGMGLVFAEGEDHKRQRKMLN (1?)
GIFSTPNMKKLLPVVQRHGKRLTETIDQRIGSESSAVVE (1)
198045 VVSLFSKATLDIIGLITLGKELDCFTAKPTFHECYDLIFNQSSLSAIITAVNTYIPL 197875
197874 RSWLPLEANRSFVTANDEVKRILRQQIRLRQKEIATARTSVKKSSLPISRDVLMYLLEA 197698
197697 PPSRQQQWTEDELLGY (0)
LLNFMSA (1)
197535 GHETSATTLTWAVHVLSTRPDIQTRLRNEIMTLPSCGEPDYTQLEGLRYLHNFCREVLRVYAP 197347
197296 AVMIWRQAAEAVIIENTYIPAGTNVIVSPQVSQSHPEIWGSSATAFEPDRWDSLPPESAS 197117
197116 PYAFQAFSSGPRVCIGKGLAMLEFKSLLVDIVRKYTFEAVEGKLVLENYLTL 196961
196960 RPKGGFRVRFKIAGEDIAQRAD*196891
CYP582C1 Grosmannia clavigera
CYP583A1 Magnaporthe grisea
MG05787.4 poor match AACU01000820 cont2.1083
See fungal pages for seq
CYP584A1 Magnaporthe grisea
MG08956.4 44% to 52A1 40% to 52F1 AACU01001733 cont2.1681
See fungal pages for seq
CYP584A2 Magnaporthe grisea
MG05908.4 40% to 52F1 AACU01000839 cont2.1108
See fungal pages for seq
CYP584B1 Magnaporthe grisea
MG08494.4 42% to 52F2 46% to 52E1 AACU01001266 cont2.1600
See fungal pages for seq
CYP584C1 Magnaporthe grisea
MG03821.4 42% to CYP52F3 AACU01001030 cont2.747
See fungal pages for seq
CYP584D1 Fusarium graminearum
FG08320.1 AACM01000333 FGcontig1.333_scaffold5
See fungal pages for seq
CYP584D2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_1000851
Necha1/scaffold_1:2763714-2765329
79% to 584D1 Fusarium graminearum probable ortholog
See fungal pages for seq
CYP584D4 Fusarium oxysporum
80% to CYP584D2 Nectria haematococca
bad ag boundary in EXXR motif = gg
See fungal pages for seq
CYP584D4 Fusarium verticillioides
93% to CYP584D4 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP584E1 Aspergillus nidulans
AN9384.1
See fungal pages for seq
CYP584E2 Aspergillus fumigatus Af293
GenEMBL XP_749919.1 also EAL87881.1
64% to 584E1
MTSNYSISLVAGAIAVFVYTLSVLRRKWTQYRFARAHNCQAPPRLASKDPLFGLDTIYATVQNVKEHKFL
ERAQARFDAVGHTIQTRRLLQTIIFTRDPQNIKTILSLRFKDYALGHRYKTFGPLLGHGIFTTDGEHWAQ
SRAMIRPNFVREQVADLAIFEAQMADLLELIPNDGRTVDLQDLFFSYTIDSATEFLFGQSVQSLKKRRSG
GRDAHAEDDFASAFNYAQHAIATRIRLGPLAAFYRDRKVERCNRVCHALVEQFVDKALEVRAQGGRVDEK
TLEDGDGEKKPRYVFLHGLAQQTGDRRRIRDEVMNVLLAGRDTTASLLSNLFFMLAKHPRIWARLRDEVA
PLNGRPPTYEQLRNLTYVKYCLNESLRLHPVVPGNARFAITDTVLPVGGGPDGQSPVFVPKGGIVTYSVW
SMHRREDIYGPDANEFRPERWADLRPGWEYLPFNGGPRICVGQQYALTEAGYVTVRLAQQFAVLESRDPG
PWEENLTLTLCSRNGTKVSLRN
CYP584E2 Neosartorya fischeri
95% to CYP584E2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP584E3 Aspergillus fumigatus Af293
GenEMBL XP_747767.1
54% to 584E1
MHLILHPKTLILLLAVLVTIVCISIRRFLARRQFARQHGCQPVARSLNKDPFLGLDTIPETLRAASQHRI
LERSVELFRLYGNTFTVKELHKYAILTIEPENIKTILSLNFKDYGLSHRLQPFKPLLGEGIFDTDGAHWA
SSRALIRPSFTRGQVADLTALEDLMQDLFALLPRDGQTVVDLQELFFRYTIDSATEFLFGQSVGTLRKTP
SELGFAQAFHYAQKAIITRGMLGPLAVFYRDRKADECNRVCRAFVQRFVDDAFRAAENNGEKTPDGTKRQ
KRIFSHELAARTSDKRRVLDELMNVLVAGRDTTASLLGNLFFVLAKKPEIWEKLRAEVACLQGRTPTYDE
LRSLRYVQCCVNESLRLHPVVPRNERQAVRDTVLPLGGGSDGLSPVFVPKGTIVSYNVYVMHRRPGLYGP
DAEEFRPERWEDGKLQPRWGYLPFNGGPRICIGQRYALTEVSYVLVRMAQEFRVLESRDPGPWEESLALT
LCSRNGTRVCLVSG
CYP584E3 Neosartorya fischeri
87% to CYP584E3 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP584E4 Aspergillus oryzae
GenEMBL BAE62566.1
SHORT MISSING N-TERM
79% TO 584E2, 73% TO 584E1, 55% to 584G1
revised 3/20/2009
MIMNSSHYPVALLAGAVVFLVYTVTALQRKYIQYRIARANNCQPV
(deletion 87 aa))
IFTTDGDHWAQSRAMIRPNFVKDQVAHLDIFEELMADLLALIPTD
GTTVDLQDLFFCYTIDSATEFLFGHSVQSLKKRLSGVKLDDNDFASSFNYAQDAIAKNTRLGPLRHFFRD
TKAEHCNQVCHELVEQFVEKALKYRANYDEEKAATDDDKKQRYLFLQGLAQQTGDPKRIRDELMNVLLAG
RDTTASLLSNMFFMLAKNPHIWNKLREEVASLEGRAPTYEQLRNLTYLKYCMNESLRLHPVVPSNARFAI
NDTVLPVGGGPDGNAPVFVPKGSIVAYSVYSMHRREDFYGPDANEYRPERWADLRPSWEYLPFNGGPRIC
VGQQYALTEAGYVTVRLAQQFSVLESRDPGPWEENLTLTLCSRNGTKVALRH
CYP584E4 Aspergillus flavus
99% to CYP584E4 Aspergillus oryzae
73% to CYP584E2 Neosartorya fischeri
See fungal pages for seq
CYP584E5 Aspergillus oryzae
GenEMBL BAE65988.1
60% to 584E4, 51% TO 584E1
MELLPKLVILLLAALGIASVSIRRFLNRRQFARRCGCQPVARSFSKDPFLGLDTIPGTIRAIRQHRVLGR
SCEIFRAYGNTFTVKELHQSAIVTIEPENIQAVLSLNFKDYTLRHRLELFMPLLGRGIFNTDGQHWASSR
ALIRPSFAREQVANLSLLERLMQDLFVLLPRDSTTVDLQELFFRYTIDSATDLLFGQSVGALKKSQSGLA
FADALQYALKAIPVRDMLGPLNAVYRDRKTDECNRICRDFVQQYVEEAVYAAGPKKEEKESRTTETKRRY
ILSHELASRTSDKQRMVDELINVLLAGRDTTGSLLGNLFFMLAKNPVIWAKLRAEVAVLQNRPPTYEELR
GLRYVQCCVNESLRLHPVVPTNKRKAMRDTVLPRGGGNDGLSPVFVPAGTLVGYNIYAMHRRTDFYGPDA
KEFRPERWEDGKLQPRWGYLPFNGGPRICLGQRYALTEASYVLVRMAQEFRGLESRDPGSWEEGLVLTVC
PRNGTKVGLIP
CYP584E5 Aspergillus flavus
99% to CYP584E5 Aspergillus oryzae
See fungal pages for seq
CYP584E6 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_19000013|Aspni1
67% to CYP584E2
See fungal pages for seq
CYP584E7 Aspergillus niger
JGI gene model estExt_fgenesh1_pm.C_10613|Aspni1
67% to CYP584E2
See fungal pages for seq
CYP584E8 Aspergillus niger
JGI gene model estExt_fgenesh1_pm.C_40266|Aspni1
76% to CYP584E5
See fungal pages for seq
CYP584E9 Mycosphaerella graminicola
61% TO CYP584E3 Aspergillus fumigatus
See fungal pages for seq
CYP584E10 Aspergillus clavatus
75% to CYP584E2
See fungal pages for seq
CYP584E11P Aspergillus clavatus
pseudogene ~70% to 584E3
See fungal pages for seq
CYP584E12 Aspergillus terreus
77% to CYP584E6
See fungal pages for seq
CYP584E13 Aspergillus terreus
63% to CYP584E12
See fungal pages for seq
CYP584E14 Metarhizium anisopliae var. acridum Ma102
CYP584E14 Metarhizium anisopliae var. anisopliae Ma23
CYP584F1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_53000004
Necha1/scaffold_53:9312-10650
47% to 584C1, 52% to 584E1, 46% to 584D1, 50% to 584C1,
48% to 584B1, 51% to 584A1
See fungal pages for seq
CYP584G1 Aspergillus oryzae
GenEMBL BAE59590.1
55% to CYP584E4, 49% TO 52H1, 44% TO 584B1
47% TO 584E1 49% TO 584E2
MAVSLSFLTYLFLIVAGVYLARKISRAVQIRQFKKRHGCLPPPRDHHKDPVLGLDEVRSMLRVFREDYLM
EYTLEKYRRHGNTFATSVLGDDDIFTAEPENIKTILAVKFKQFDLGETRRRTFHPLLGDGIFAADGPQWE
HSRTLLRPSFTRTQIAATDLHERHIQRLISRIPRDGSTVDLQELFFNLTLDTATEFLFGESVESLRLGSS
AGSSSFAHHFNVAQDEIAFSMVIAPFDQLIFRPRFRESVREARGYVGNFVKKAIEYRHSLDAEKHAGDTT
DSQSRYVFLEELAKETDNPSDITDQILNILLAGRDTTASLLSMVFYNLARRPDIWDLLRSEVATLDGKCP
SFEELKQLKYLSWVINETLRLYPVVPSNSRTANEDTFLPVGGGPDGKSPVFVAKGQRVAYDVYVMHRRHD
IFGPDAEEFRPERWETIRPGWGYLPFNGGPRICLGQQFALTEASYTTVRIVQSFKEITSRDPEPYRERLA
LTLASRHGTKVAMVPA
CYP584G1 Aspergillus flavus
99% to CYP584G1 Aspergillus oryzae
See fungal pages for seq
CYP584G2 Neosartorya fischeri
56% to CYP584G1
Note: this seq has no ortholog in A. fumigatus
See fungal pages for seq
CYP584H1 Aspergillus niger
JGI gene model e_gw1.19.73.1|Aspni1
44% to CYP584E2
See fungal pages for seq
CYP584J1 Mycosphaerella graminicola
51% to CYP584E2 Aspergillus fumigatus (yellow region is long)
41% to 548E9
See fungal pages for seq
CYP584J2 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_90431
67% to CYP584J1 Mycosphaerella graminicola
See fungal pages for seq
CYP584K1 Uncinocarpus reesii
47% to CYP584G1, middle region similar to EST from Coccidioides
posadasii GH403863.1
See fungal pages for seq
CYP584K2 Coccidioides immitis
80% to CYP584K1
See fungal pages for seq
CYP584L1 Uncinocarpus reesii
49% to CYP584G1, 45% to CYP584K1
See fungal pages for seq
CYP584L2 Coccidioides immitis
76% to CYP584L1, shortened the N-term
See fungal pages for seq
CYP584L3 Histoplasma capsulatum G217B
ABBT01000202.1 Ajellomyces capsulatus G217B
64% to CYP584L1
See fungal pages for seq
CYP584M1 Aspergillus clavatus
44% to CYP584E2
See fungal pages for seq
CYP584N1 Mycosphaerella fijiensis
JGI gene model gw1.8.206.1 revised at N-term
44% to CYP584E12 Aspergillus terreus
44% to CYP584E10 Aspergillus clavatus
See fungal pages for seq
CYP584P1 Metarhizium anisopliae var. acridum Ma102
CYP584P1 Metarhizium anisopliae var. anisopliae Ma23
CYP584Q1 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-8
49% to CYP584E12 Aspergillus terreus ATEG_02893.1
46% to CYP584E2_Neosartorya_fischeri NFIA_022940
CYP585A1 Magnaporthe grisea
MG10071.4 38% to 52F5 AACU01001328 cont2.1928
See fungal pages for seq
CYP585A2 Alternaria solani
Alt2 BAD83681 65% to 585A1 Mg
PKS for alternapyrone is next to three P450s called alt1, 2, 3
Chem Biol. 2005 Dec;12(12):1301-9.
1 MQTHLLILAA VVLLIIHIVN NFLIKPLQTL LKSRRLGCGP VPFEPTRWPL DIDTIRRSLK
61 ADKEQRTPDF VAGRFETMGR YTWGLSLLGT SNLITAEPRN VQALLATQFD DFIMGTARRT
121 NLKTALGRSI FAVDGKAWHR ARETMRPIFS RENVSRLELL EEHVQTMLQI IETKDEGLTT
181 DANDRAWSAP VSLAVLLPRL TMDSATELFL GQSTHSLKKA LARQQQKSGN EEHDADSFDH
241 AFERMLAILG TRMRLRSLYW LYGNKELQKC INALHAFVDS AIDAADQARK SGSSQLRYDF
301 LETLRTRCSD RAEVREQVLG LLAAGRDTTA SLTAWVFYCL VRNPRVYKKL RDTVLAEFGP
361 YSTNPGQKIT FEKLKGCTYL QHVLNETLRL HSVVPFNSRC AARDTTLPVG GGPDGSMPVF
421 VPKGTEVNFS THVLHRRKDL WGEDADEFVP ERWEKKRPGM TWQYVPFNGG PRICIGQQFA
481 LTEAGYVLVR MVQRYDVIEG LDIDVERDWH NFTVVCSPGS PVARDAAVMC RLRVAVE
CYP585A3P Fusarium oxysporum
59% to CYP585A1, stop codon, frameshift = &, no start Met
See fungal pages for seq
CYP585B1 Magnaporthe grisea
MG08947.4 42% to 52F5 AACU01001732 cont2.1680
See fungal pages for seq
CYP586A1 Magnaporthe grisea
MG09179.4 poor match AACU01000638 cont2.1755
See fungal pages for seq
CYP586B1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.24.71.1
Necha1/scaffold_24:469714-471122
46% to 586A1 Fusarium graminearum
See fungal pages for seq
CYP586C1 Aspergillus fumigatus
GenEMBL XM_743428.1 Predicted mRNA, end probably wrong
AAHF01000010 revised
47% to 586B1
MNFADMFLILSVIATLQLLAFWLLNKLDYYRIKQFAAWPQPKPSRIWGHMKDLNAFISRGEPNRHIGK (2)
EDYVFAEIKAHLGNPPLYLLDARP
MQHPLGIVCSHEIAEQVSRSSKQFPYGLPKTPTLQDYKYL VGPHSILTSE
GEEWKSLRKRFNPGFAPQHILTLLPRILDKTVPFFETLDRYAESGEEFSLAETCTNLTFDII (1?)
GAVTMDEDLGAQL
PLDKQSEMVRLYHELTASYHQKSSVRAKPSNPLVIWQQYKLARKLNAIIKNHIKRKFA
ELKEASSDEKKSRSVLALSLQGIEKLDAHVLDQTCDQLKTFLFAGHDTTSIVLQWAFY
ELSRTPRVLESISRELDDVFGPDPSPAVVRDKLLAPNGGELLSKLPYTTAVIKEILRV
YPSSGTGRLVPEGSDVYIQLPDGRSLCIDGVLMYNCETLIHRDETVYGESKDDFLPER
WLGDSGADRIPSSAWRPFERGPRSCIGQGLATIEAQVILACAVRQYEFVKIGLGEVAR
DNAGEPILGPQGQYEVKSKLFNV (1)
MTAKPVDGMIMKVKLSSGGRKEL*
CYP586C1 Neosartorya fischeri NRRL 181
DS027697
join(701574..701711,701768..701954,702008..702981,
703037..703117)
92% to 586C1 = ORTHOLOG
51% to 586B1, 48% to 586A1
NAME REVISED FROM CYP586C2
Seq revised
MGIVCSHEVAEQVARSSKQFPYGMPKTPTLQAYKYLLGPHSILT
SEGEEWKSLRKRFNPGFAPQHLLTLLPCILDKTVPFFETLDRYAQSGEefslaetctn
ltfDIIGAVTMDEDLGAQLPLDKQSEMVRLYHELAASYYRKSSVRAKALNPLLIWQQY
TLARTLNAIIKNHIKRKFAELKEASTDEKKSRSVLALSLQGIEHLDAHVLDQTCDQLK
TFLFAGHDTTSILLQWAFYELSRTPRVLESIRRELDDVFGPDPSPAVVRDKLLAPNGG
ELLSKLQYTTAVIKEILRVYPSSGTGRLVPEGSDAYIQLPDGRSLCIDGILMYNCETL
IHRDETVYGESKDDFFPERWLGDAGADRIPSSAWRPFERGPRSCIGQGLVTIEAQVIL
ACAVRRYEFVKIGLGEVARDSAGEPILDPQGQYEVKSKLFNTMQVTAKPVDGMIMKVK
LSSGGRKEL
CYP586C3 Aspergillus niger
JGI gene model e_gw1.3.1357.1|Aspni1
63% to CYP586C2
See fungal pages for seq
CYP586C4 Neosartorya fischeri
56% TO CYP586C2 Neosartorya fischeri
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP586C5 Aspergillus terreus
62% to CYP586C3 Aspergillus niger
See fungal pages for seq
CYP586C6P Aspergillus clavatus
~50% to CYP586C3
See fungal pages for seq
CYP586D1 Aspergillus niger
JGI gene model estExt_Genewise1.C_70085|Aspni1
44% to 586B1
See fungal pages for seq
CYP586E1 Histoplasma capsulatum G217B
ABBT01000222.1 Ajellomyces capsulatus G217B
45% to 586C3
See fungal pages for seq
CYP586F1 Metarhizium anisopliae var. acridum Ma102
CYP586F1 Metarhizium anisopliae var. anisopliae Ma23
CYP586G1 Metarhizium anisopliae var. acridum Ma102
CYP587A1 Magnaporthe grisea
MG10009.4 AACU01001316 cont2.1914
See fungal pages for seq
CYP587B1 Fusarium graminearum
FG04249.1 AACM01000185 FGcontig1.185_scaffold2
See fungal pages for seq
CYP587B2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.18.184.1
Necha1/scaffold_18:122860-124804
53% to 587B1, 41% to 587A1
See fungal pages for seq
CYP587B3 Gibberella moniliformis
GenEMBL AAIM01002228.1
58% to 587B2
4962 MWLLGLQDDGASLLTRLLRFSGVILVALLVHAFRKGYRVRKKFQALKDQGI (0) 5114
5167 PIMKHSMILGHLEVIGKLVSTLPSDAHGDYLMLKIQENWRELFPQCTKCPPVAYIDTWPF 5346
5347 TAPMVISLNAHVSAQFTQEHSLPKAYEQKHVLYPLTKNRDLASMEGPEWKVWRKRLSPAF 5526
5527 SIQNINSRLPDILEEVEDFANVLKSKAGKNGEWGEVFPLGDATANLTLDVIIRLFL (2)5694
5762 NIRFHEQWGKSSPVCAALLDTISRMYFFVNPANFIQYCNPWRHFKLWQNYRTLVKSFTPV 5941
5942 LQERMNKLQQDRTAKGKTLVDLIVQALDAERAEQKGAGQDDKDQLNMELDADFLEMAIG 6118
6119 QINTFLFAGFDTSAATIAWLFRLLSEYPDVLAKLREEHDAVLGPNAWGVAGVIRENPQLL 6298
6299 NQLPYTLAVLRESMRYHTNVGSMRRGEPGFFLVGPPGSDPGFEGKKLPTEDFIVWDGTYA 6478
6479 IHRDPEIWHRAWEFLPERFLVTDPEDPLYPPPNGWRSFEAGPRVCIGQHLATLEMKLAMV 6658
6659 LVARCFDIECAWEEWDQIN(2) 6715
6779 GTTNSEKARPTVWDDRCYQVGTDSPPRVKDGMPVHVRTRGL* 6904
CYP587B3 Fusarium oxysporum (temp 587B5)
94% to CYP587B3 Gibberella moniliformis
See fungal pages for seq
CYP587B4 Aspergillus terreus
GenEMBL AAJN01000219.1
56% to 587B2
5121 MGLLSNFQNHDSSYLLLQSVTALLVTASAYGLYRGYQVRSMFQSLKKQGI (0) 5002
4919 PLMPHSMIFGHLEVIGKLMSRIPSDAHGDYMMVLIQENWKELFPGCSKCPPVLYIDLWPF 4740
4739 APPMLISINPDTSAQCTQDYSLPKAYQQKRTLYPLTRNRDVSSMEGAEWKVWRKRLNPGF 4560
4559 SIQNITSRISDILEEVEVFVGVLEARAGNDGAWGEVFPLENATTNLAMDVILRFFL (2)4392
4329 NKRFHQQTGPRSPITVALLDTISRMYFYVNIFNFLSYISPWRHFKLWLNYRTLFNSLSPF 4150
4149 LTERINEIQKNSQVTNKTLIDLLVKAMDEEKGTNGAAGDLSTNTDFLETAIGQI 3988
3987 TTFLFAGHDTTASTICWLFRLLEQHPDILSKLRAEHDAILGPDPSQAAAALRANPQLLNA 3808
3807 LTYTNAVLKESTRVHTNVGTMRRGEPGFFLTGPPGSGPECEGKQMPTDGFVVWDGNFAIH 3628
3627 RSPDVWPRPNKFIPERFLVTDENDPLHPPKNAWRFFELGPRGCIGQHLAMVEIKLVMALV 3448
3447 VRRFDIECAWDEWDSKR (2) 3397
3356 NFKGPQNMVWGDRCYQVGGDSPPHVKDGMPVHVRVR 3236
CYP587C1 Metarhizium anisopliae var. anisopliae Ma23
CYP587D1 Grosmannia clavigera
CYP588A1X name changed to CYP534B1
CYP588B1X name changed to CYP534C1
CYP589A1 Magnaporthe grisea
MG08234.b 2 fused P450s poor match to second half
AACU01000307 cont2.1540
See fungal pages for seq
CYP590A1 Magnaporthe grisea
MG08795.4 poor match AACU01001208 cont2.1657
See fungal pages for seq
CYP590A2 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000245.1
52% to 590A1 Magnaporthe grisea
128907 MGLLLIGIVAILLIWIMSHLRIFIRNYNAARATGLPIIICPYDPDS (0)
VVFTFISEPLRPLLKPILPASIFAVFDATCWGWEFHDK 129266
129267 GAAHEKFGDAFIMVTTGHNRLVCADPAMSQSVLARRKDFHHPELSKKTMGVLGPNLVT (0) 129440
SRDESWSRQRRIIAPTFNERISLDV 129626
129627 WKEGVQQASALVDHVLSSSTLSQSMTLSTSPAADKSSDSLPGLRAIAINVLTRVAYGRHT 129806
129807 PFSIASSYRDATKALTYVDGIALVVDLLLVAAFIPAGILRLPFMPQLSKKLGQAMVKLPD 129986
129987 LTVDMLDQERKRISSADSKEFQNTIMTTLVRLSDQGREQDDDQGSSGK 130130
130131 SVATGGNKQYLTEEEIAGNLFIFTAAGFDTTSNTMSYAICLLAAYPEWQAWIQAEIDVVL 130310
130311 GAGDHEQISLEDYTAIFPKLTRCLAVMFETLRVYPAVSLLIRTVETNQTIFPSSSKS 130481
130482 DSFILQAPCAVHVNIMALHTSRSTWGADTLDFKPARWFPEGQDSMYVPPRGTFMP 130646
130647 WSSGPRNCPGQKMSQVEFVSVVMTLFGKCSVEPVAEKGQTVKQARERLLGLLQDSQPVLT 130826
130827 LQINKPREVKLKWTRR* 130877
CYP591A1 Magnaporthe grisea
MG03811.4 poor match AACU01001028 cont2.745
See fungal pages for seq
CYP592A1 Magnaporthe grisea
MG07488.4 poor match AACU01000906 cont2.1392
See fungal pages for seq
CYP593A1 Magnaporthe grisea
MG02292.4 poor match AACU01000444 cont2.449
See fungal pages for seq
CYP593-un Magnaporthe grisea
MG09380.4 poor match AACU01001225.1 cont2.1796
Pseudogene
See fungal pages for seq
CYP595A1 Magnaporthe grisea
MG09156.4 35% to 68D1 AACU01001649 cont2.1746
See fungal pages for seq
CYP595B1 Aspergillus oryzae
GenEMBL BAE58469.1
46% to 595A1
MFGQIFSSVFAWTLIAILAGLYRFTTKQRPIFPVVNDYRGDFFRRKAYREYNQNAKKLIVDGLAKHGSPI
TLRVPDGLKIVLPSALSEWVKTNRDLDHQELIREEYFAGFPGFEAQDTLHAPDGMLIKLLRTNLSQNEEI
VPTVNRHIGPALQHYWGDSGIWHTIDWEDDTTGIISRAAASIFVGPEKAADDEWQTVVQAYVREYFAAVS
ELHTWRASLRPIVQWFLPHASACRRLLHQSRAIMQEVVRKREREAQAAEDQGLVAPRYNDVLAWTMQVPD
NKHPAGDIQLALAMAALFTTTELFKQILINIARHPELVEPLRKEIKTSLLGHGLGLTALAKMELLDSVMK
ESQRQIPVTVGLERKVIRDTSLPDGTKLPKGSHIMVDATDMWNPEVHVNPEVFDGYRFLKRRHAGDKASQ
FVQSSREHIVFGGGRHICPGRFFAGTELKLCLAHILLKYDIRLKEGYYPQPMVLGVYAIVDPMTQLEVRR
REHTEDLVF
CYP595B1 Aspergillus flavus
99% to CYP595B1 Aspergillus oryzae
See fungal pages for seq
CYP595B2 Fusarium oxysporum
55% to CYP595B1
See fungal pages for seq
CYP595B2 Fusarium verticillioides
90% to CYP595B2 Fusarium oxysporum
See fungal pages for seq
CYP595B3 Aspergillus terreus
72% to CYP595B1 Aspergillus flavus
See fungal pages for seq
CYP595C1 Mycosphaerella fijiensis
JGI gene model e_gw1.7.216.1
47% to CYP595B3 Aspergillus terreus
See fungal pages for seq
CYP596A1 Magnaporthe grisea
MG10351.4 39% to 68A1 AACU01001708 cont2.1991
See fungal pages for seq
CYP596B1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_19000057
Necha1/scaffold_19:141600-144731
43% to 596A1, 40% to 68A1, 38% to 68J1,
41% to 68B1, 41% to 68D1, 39% to 68L1
See fungal pages for seq
CYP596C1 Mycosphaerella graminicola
JGI gene model e_gw1.7.728.1|Mycgr3
47% to CYP596B1 Nectria haematococca, 43% to 596A1 N-term from JGI model
See fungal pages for seq
CYP596D1 Mycosphaerella fijiensis
JGI gene model gw1.2.702.1
42% to CYP596C1 Mycosphaerella graminicola
41% to CYP596B1 Nectria haematococca
See fungal pages for seq
CYP597A1 Magnaporthe grisea
MG01700.4 36% to 68D1 less to other 68s AACU01000096 cont2.318
See fungal pages for seq
CYP598A1 Magnaporthe grisea
MG10345.4 poor match AACU01001708 cont2.1991
See fungal pages for seq
CYP598B1 Mycosphaerella graminicola
JGI gene model e_gw1.9.207.1|Mycgr3
55% to Mgr073, 44% to 598A1, 39% to 68L2 N-term from JGI model
See fungal pages for seq
CYP598B2 Mycosphaerella graminicola
55% to Mgr069, 41% to CYP598A1 Magnaporthe grisea, 41% to 68D2
See fungal pages for seq
CYP598B3 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_110219 revised at N-term
53% to CYP598B1 Mycosphaerella graminicola
49% to CYP598B2 Mycosphaerella graminicola
See fungal pages for seq
CYP598C1 Mycosphaerella fijiensis
JGI gene model e_gw1.29.34.1
38% to CYP598B3 Mycosphaerella fijiensis
38% to CYP598B1 Mycosphaerella graminicola
37% to CYP598B2 Mycosphaerella graminicola
See fungal pages for seq
CYP598D1 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_10000124
49% to CYP598B3 Mycosphaerella fijiensis
See fungal pages for seq
CYP599A1 Magnaporthe grisea
MG01950.4 34% to CYP54A1 38% to MG08459.4
AACU01000379 cont2.368
See fungal pages for seq
CYP599B1 Magnaporthe grisea
MG08459.4 poor match 38% to MG01950.4
AACU01001260 cont2.1594
See fungal pages for seq
CYP601A1 Magnaporthe grisea
MG00238.4 31% to 54A1 poor match AACU01001391 cont2.57
See fungal pages for seq
CYP602A1 Magnaporthe grisea
MG09198.4 poor match AACU01000639.1 cont2.1756
See fungal pages for seq
CYP602B1 Fusarium graminearum
FG01868.1 AACM01000100 FGcontig1.100_scaffold1
See fungal pages for seq
CYP602B2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.13.286.1
Necha1/scaffold_13:161330-162748
78% to 602B1 probable ortholog
See fungal pages for seq
CYP602B3 Fusarium oxysporum
84% to 602B1, one frameshift
See fungal pages for seq
CYP602B3 Fusarium verticillioides
97% to CYP602B3 Fusarium oxysporum
See fungal pages for seq
CYP602B4 Grosmannia clavigera
CYP603A1 Magnaporthe grisea
MG08385.4 poor match about 40% to MG08379.4
AACU01000341 cont2.1578
See fungal pages for seq
CYP603B1 Magnaporthe grisea
MG08379.4 poor match about 40% to MG08385.4
AACU01000340 cont2.1577
See fungal pages for seq
CYP603B2 Metarhizium anisopliae var. anisopliae Ma23
CYP603C1 Aspergillus clavatus
51% to CYP603B1
See fungal pages for seq
CYP604A1 Magnaporthe grisea
MG02272.4 poor match AACU01000440 cont2.445
See fungal pages for seq
CYP605A1 Magnaporthe grisea
MG08387.4 poor match AACU01000342 cont2.1579
See fungal pages for seq
CYP605B1 Magnaporthe grisea
MG08378.4 poor match AACU01000340 cont2.1577
See fungal pages for seq
CYP605B2 Aspergillus clavatus
53% to CYP605B1
See fungal pages for seq
CYP605B3 Metarhizium anisopliae var. anisopliae Ma23
CYP606A1 Magnaporthe grisea
MG04349.4 poor match 58% to MG03104.4 AACU01001098 cont2.822
See fungal pages for seq
CYP606A2P Magnaporthe grisea
MG03104.4 (version4) poor match 58% to MG04349.4
AACU01001602 cont2.617
See fungal pages for seq
CYP606A3P Aspergillus terreus
53% to CYP606A2P, 50% to CYP606B1
possible first exon followed by a frameshift (&) and deletion
of most of the P450 sequence
See fungal pages for seq
CYP606B1 Fusarium graminearum
FG11282.1 AACM01000464 FGcontig1.464_scaffold9
See fungal pages for seq
CYP606B2 Fusarium oxysporum
76% to CYP606B1
See fungal pages for seq
CYP606B2P Fusarium verticillioides
90% to CYP606B2 Fusarium oxysporum = ortholog,
frameshift and 5 aa deletion
See fungal pages for seq
CYP606C1 Aspergillus clavatus
43% to CYP606B1
See fungal pages for seq
CYP607A1 Magnaporthe grisea
MG07247.4 poor match AACU01000236 cont2.1347
See fungal pages for seq
CYP607B1 Metarhizium anisopliae var. anisopliae Ma23
CYP608A1 Magnaporthe grisea
MG10356.4 poor match AACU01001708 cont2.1991
See fungal pages for seq
CYP608A2 Uncinocarpus reesii
68% to CYP608A1
See fungal pages for seq
CYP608A3 Aspergillus terreus NIH2624 XM_001218190
75% to CYP608A2 Uncinocarpus reesii
See fungal pages for seq
CYP609A1 Magnaporthe grisea
MG07210.4 poor match AACU01000230 cont2.1339
See fungal pages for seq
CYP610A1 Magnaporthe grisea
MG01865.4 29% to 533A1 poor match AACU01000128 cont2.354
See fungal pages for seq
CYP611A1 Magnaporthe grisea
MG10355.4 poor match AACU01001708 cont2.1991
See fungal pages for seq
CYP611A2 Uncinocarpus reesii
57% to CYP611A1 Magnaporthe grisea, missing N- and C-terms
See fungal pages for seq
CYP611B1 Metarhizium anisopliae var. anisopliae Ma23
CYP612A1 Magnaporthe grisea
MG10862.4 P450 part poor match AACU01000368 cont2.2095
See fungal pages for seq
CYP613A1 Magnaporthe grisea
MG07743.4 poor match
AACU01000945 cont2.1439
See fungal pages for seq
CYP613B1 Aspergillus fumigatus Af293
GenEMBL XP_750856.1 also AY838877
GliC in the gliotoxin biosynthetic gene cluster
39% to 613A1
MAFTLTILVPCMVLALVAARPVLYWVLSVVIDAFLRWKYPLPHHAGSKPMPRARYTWPNGQGTEKFFNGR
SAARQWRQRWGPIYQIWSGWCPEIVLTTPTHAVQFFRNSHRHTKAVNNDSGWLFGEVLGVCVGLLSGTDW
KRVRQQVEDGFSRPTAARYTGDLVFLAREYLQNTLLASSEQSLENKGIIHVEPAKTLQFYPFLSVAQILF
GRLSPMQRTQLTTLAPLREELFKEVIRGGINRLSIAPWFKSRGVRLLNEFQTQWEQFVEDAYHAAVKRNQ
SPRPLVIGLWEAYQAGTISKRECLQTLDESLYANLDVTTHALSWNVLLLAENGEAQTELRQEVLSALQSE
ASESYERYIDRDDTFLAACILESARLRPILPFSNPESAPEDLYVDGYLIPAN (0)
TNVIVDAQAINIDNPYWVNGTQYNPRRFFSLNKSDVRHNMWRFGFGPRQCLGKHIGERMLKAIVAEIIRQ
YVISISADSALKNDLQEDSWVGLPATRIQCVPVGREVEKN
CYP613B1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000024.1
95% to 613B1 Aspergillus fumigatus,
name changed from CYP613B2
MAYALTILVPCLVLALVAARPVLYWVLSVVVD (0)
AFLRWKYPLPHHAGSKPMPRARYT
WPNGQGTEKFFNGRSAAKQWRQQWGPIYQIWSGWSPEI (2)
VLTTPTHAVQFFRNSHRHTKAVNNDSGWLFGEVLGVCVGL
LSGSDWKRVRQQVEDGFSRPTAARYTADLVTLAREYLQSTLLTSSEQSVEKKGIIHVEPA
KTLQFYPFLSVAQILFGRLSPMQRTQLTTLAPLREELFKEVIRGGINRLSIAPWFGSRGV
RLLNEFQTQWERFVEDAYHTAVKRNQSPRPLVIGLWEAYQAGTISKRE (0)
CLQTLDESLYANLDVTTHA
LSWNVLLLAENGEAQTELRQEVLSALQSEASESYERYIDRDDTFLAACVLESARLRPIL (1)
PFSNPESAPEDLYVDGYLIPAN (0)
160249 TNVIVDAQAINIDNPFWVNGTQYNPRRFFSLNKSD (0)
VRHNMWRF 160428
GFGPRQCLG 160455
KHIGERMLKAIVAEIIRQYVVSISADSALEKNVLQEDSWVGLPATRIQCVPVGRE
VEKN*
CYP613C1 Aspergillus oryzae
GenEMBL BAE56604.1, AP007154.1
72% to 613C2, 51% to 613A1, 50% to 613D1, 39% to 613B2
MLWILVAVVVIVGISSPFTRRITIEILSTILD (0)
90386 RYLRSRFPIFSVDGSRTLPTCPYKWPNGQGDVAKFLQGIENRDLWEKEHGQ
IYRIWSGMKSEVVLTQPSHLQAVFRDSNKHSKAENNNSGYL MSELLGQCVGLVSRERWRTLRAVTEIPFQ
HDKMPSYLELIQRHTRHHFDRLLASGDLRQERIHPAQDLKMLPFWVVAEIFYGECDAEMKTELQQLCVLR
EDLFKRMIQGGIVRWQWSKYLPTATNRALAEFQRRWRAFNQRAYDRACQQQRILPIVLMIEAAREGSTSV
EQIYQTIDEALFANLDVTTGGISWNLVFFAAHSDIQERVRQEVLSATDHDAYLLSSSTLLAACISESARL
KPLAAFTVPQSAPTDRIIGGYNIPAGTNLVVDTYALNIRNGFWGADSQCYRPDRFLEHRATELRYQYWRF
GFGPRQCMGRYVADLVIRTLLAHLVAHYELGWVEPDPGKNSTWQRDLESWITIPDLQLRCVQRRND
CYP613C1 Aspergillus flavus
99% to CYP613C1 Aspergillus oryzae
See fungal pages for seq
CYP613C2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000041.1
note: this sequence is upstream of the pseudogene CYP-un3
72% to 613C1, 49% to 613A1
MPWIILALPVLVLVTLLPRKVTNSIFSAIID (0)
24668 KYLRWRYPIRSIDGTHTLPTCPYQWPNGQGDVGKFLQGIENRDAWEKEHG
KIYRIWSGMKPEV (2)
VLTQPHHVQSVFRDSNKHSKAENNNSGYLMSELLGQCVGLISQEPWRHLRAVAEVPFQHD
KAPAYVQLVLRHIRQHFSSLHVHGDLQQGRIHPAQDLKMLPFWIVAEIFYGEIDIAMREE
LQQLCLIREQLFRRMIQGGLVRWRWSRYVPSATNRELTDFKSRFRRFNQQAYQHACNQNK
WSLPIVSMTEAAQSGKVSLEQIYQTIDEALFANLDVTTGGISWNLVFLAAHPEIQNRVRD
EAQTATACEAYLLSSSTLLAACVLESARLKPLAAFTVAQSAPTDRTVEGYCIPAGTNIVV
DTYALNIHNEFWGTDSQSYRPDRFLKHRATELRYQYWRFGFGPCQCMGRYVADLVIRALL
AHLVENYTMGILDGDEDKWKRDSESWITLPDMQLKCEPRDVPMTKL* 23208
CYP613C3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_11000488|Aspni1
53% to CYP613C1
See fungal pages for seq
CYP613D1 Aspergillus oryzae
GenEMBL BAE58578.1 AP007155.1
50% TO 613C1, 47% to 613A1, 48% to 613C2
MGFSIQHGLTKPEILYPFLFGIFAVASLCIATLLFPASFSAASRVISWVLS (0)
4127460 IYLELKNPIRHTETGRNIPGPSYVWPNGQGDIEKYVQGRSRSEQWQRKYGNVYRIWAGMTPEV 4127272
4127213 VLTRPEQLHAVFKDSDKHTKATNSDSGYF
MSRILGQCLGLMAGPRWKLLKGTAAPPFMHPTAVRSIGRIQEHVRAHFHDLETNGNLREGRIHPVQDLKM
LPFFIVAEANYGSLTPAMKSELDSLAPARENLMKFVLFGGLARFNISRFFPTEANRQLRRFRSQWRAFNR
AAYERAREKHPSAMVVQMYDAVHKGVLTEEQVAQTMDETLYANLDVTTGGLSWNLVFLAANPACQARLHE
EISALTPAEEEGYISRNGTYLAACVLESSRLRPALPFTIPQSAPTERVVDGYRIPAGTNYVVDTWGLNVR
DEFWAPDNSTYRPERFLNSSNTDLRYHFWRFGFGPRQCIGRYTADVVIRAILLHLVKHYELQMLEEGDFT
QDPECWITHPDLQVKPN
CYP613D1 Aspergillus flavus
99% to CYP613D1 Aspergillus oryzae
See fungal pages for seq
CYP613E1 Mycosphaerella graminicola
48% to 613C2
See fungal pages for seq
CYP613F1 Neosartorya fischeri
42% to CYP613C2
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP613G1 Aspergillus terreus
50% to CYP613C2
See fungal pages for seq
CYP613H1 Metarhizium anisopliae var. acridum Ma102
CYP614A1 Fusarium graminearum
FG02113.1 AACM01000111 FGcontig1.111_scaffold1
See fungal pages for seq
CYP614A2 Fusarium oxysporum
91% to CYP614A1
See fungal pages for seq
CYP614A2 Fusarium verticillioides
94% to CYP614A2 Fusarium oxysporum
See fungal pages for seq
CYP615A1 Fusarium graminearum
FG08183.1 AACM01000329 FGcontig1.329_scaffold5
See fungal pages for seq
CYP615A2 Fusarium oxysporum
88% to CYP615A1
See fungal pages for seq
CYP616A1 Fusarium graminearum
FG09671.1 AACM01000401 FGcontig1.401_scaffold6
See fungal pages for seq
CYP616A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.5.226.1
Necha1/scaffold_5:198240-199706
72% to 616A1, no introns probable ortholog
See fungal pages for seq
CYP616A3 Fusarium oxysporum
74% to CYP616A1
See fungal pages for seq
CYP616A3 Fusarium verticillioides
90% to CYP616A3 Fusarium oxysporum = ortholog,
possible gc boundary at VEY
See fungal pages for seq
CYP617A1 Fusarium graminearum
FG01048.1 AACM01000052 FGcontig1.52_scaffold1
See fungal pages for seq
CYP617A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.2.235.1
Necha1/scaffold_2:1188558-1190265
73% to 617A1, probable ortholog
See fungal pages for seq
CYP617A3 Fusarium oxysporum
85% to CYP617A1
See fungal pages for seq
CYP617A3 Fusarium verticillioides
96% to CYP617A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP617A4 Metarhizium anisopliae var. acridum Ma102
CYP617A5 Metarhizium anisopliae var. acridum Ma102
CYP617A5 Metarhizium anisopliae var. anisopliae Ma23
CYP617A6 Grosmannia clavigera
CYP617B1 Fusarium graminearum
FG02118.1 AACM01000111 FGcontig1.111_scaffold1
See fungal pages for seq
CYP617B2 Fusarium oxysporum
87% to 617B1
See fungal pages for seq
CYP617B2 Fusarium verticillioides
95% to CYP617B2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP617B2X Aspergillus nidulans
Name changed to CYP617D1
CYP617C1 Fusarium graminearum
FG10461.1 AACM01000435 FGcontig1.435_scaffold7
See fungal pages for seq
CYP617D1 Aspergillus nidulans
AN1884.1 38% to 547A1 46% to 617A1 547 clan
Name changed, formerly CYP617B2
See fungal pages for seq
CYP617D2 Aspergillus fumigatus Af293
GenEMBL XP_749561.1
61% to 617D1
MTVKIPWPAVYLAIAASVYMRPQYAILDSLTATFVVLSLAVTSFRIIYAFVLYPKFFTPIKHIPTPSNWS
WLTGNTSSYLIESPFEEMIEWAYKVPNNGLIRYYIFGNLERVLLTNPKALSELLVTKVYEFPKPQLVRQS
LARVTGKHGVLLVEGDEHKRQRKNLMPAFSYRHIKNLYPIFWSKSIEMVKLIEKDLHSRADAKDNIVRVS
EWASRATLDIIGVAGMDHDFGSLHDSNNELTKHYRRLLEEPPLAMRIIFVLGVLFGSVGVVESLPLKRNR
EIRESSLYIRDVARQMIRKKEAKMKSQASAETGTDIVSVALESGAFTEEELVDQMMTFLAAGHETTSTAL
QWSVYALCKHPDVQTRLREEVRTHLPPISPEHPEPLSAATLDSLPYLNAFCNEVFRFHPSVPGTVRDAAK
DTTLLGYPIPKGTRILVSPEVINHSKELWGPDADQFNVERWLGSGRANTGGASSNYSFLTFLHGPRSCIG
QGFAKAELACLVAAIVGRFQMELKDADAKLEVRRSATVAPKDGVLARFTPLEGW
CYP617D2 Neosartorya fischeri
95% to CYP617D2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP617D3 Aspergillus fumigatus Af293
GenEMBL XP_754149.1
55% to 617D1
MGPIHNYFGVVCLGIAASVYFRPECALYGSRIATFAVLLTGIAISKLLYQLFIYPQFVTPLKHFPAPPNR
HWLTGNTGSLLVDTPHALMKEWAKTIPNDGILRYYIVGNMERLTVTSPAVLREILVSKAYEFAKPLVIQQ
TLRRVLGNGILIAEGEEHKFQRKNLKPAFAYRHVKDLYSVFWSKGTEMTKLIRNDLQSRKAPDDNTIQVR
TWASRSSLDIIGLAGMGRDFGSLQDPENSLSRSYEMIFATPGLGTKILFILGMLLGNTTWLAKLPTKQNR
LIDTGCRNIRDATRRMIREQKAKMEDPNAAAEVDIISVAMRSGNFDDDNLVDQLMTFLGAGHETTAGALQ
WAIYALCKHPDVQSRLREEVRANLPPIHGENPGPIDAATIDSLPYLNAVCNEVIRFHPSVPNTVRVALND
TTLMGHPIPKGTQVVISPELVNHMPALWGPDAERFNPDRWMGPGKANTGGAASNYAFLSFLHGPRSCIGQ
VFAKAELACLLAAVVGSFAFELKSPDAPLEVREGATIAPKDGVLAKFTPVEGW
CYP617D3 Neosartorya fischeri NRRL 181
NZ_AAKE03000007, NFIA_062490
93% to 617D3 Aspergillus fumigatus = ortholog
54% to 617D1, 46% to 617A1
19kb from PKS 51% to chr 6 Nectria PKS
name changed from CYP617D5, revised seq 3/11/2009
MGPIRNYSGVLCLGIAAGVYFSPECAIYGSRIATIAVLITGITISK
87863 LLYQLFIYPQFVTPLKHFPAPP (0) 87798
87742 KRHWLTGNTGSLLVDTPHALMKEWAKTIPNDGILRYYIVGNMERLTITSPAVLSEILVSKAY 87557
87556 DFAKPLVIQQTLRRVLGNGILIAEGEEHK (0) 87470
87411 FQRKNLKPAFAYRHVKDLYPVFWSKGTEMARLIRKDLQSRKAPDDNTIQVRTWASRSSLDI 87229
87228 IGLAGMGRDFGSLQDPENSLSQSYEMIFATPGLGTKILFILGMLLGNTTWLAKLPTKQNK 87049
87048 LIDTGCRNIRDATRRMIREQKVKMEDPNAEAEVDIISVAMRSGNFDDDNLVDQLMTFLGA 86869
86868 GHETTAGALQWAIYALCKHPDVQARLRDEVRANLPPINVENPGLIDAATIDSLQYLNAVC 86689
86688 NEVIRFHPSVPNTVRVALKDTTLMGHPIPKGTQVVISPELVNHMPALWGLDAEQFNPDRW 86509
86508 MGPGKANTGGAASNYAFLSFLHGPRSCIGQVFAKAELACLLAAVVGSFEFE 86356
86355 LKYPDAPLEVREGATIAPKDGVLAKFTALEGW* 86257
CYP617D4 Aspergillus oryzae
GenEMBL BAE57429.1
53% to 617D1, 63% to 617D2, 54% to 617D3
MMGLPWATVYIVIAGYAIAKSTFGNFILLSILVSLLKVFYNWVLYPDFFTPIKKIPSPPGRSWITGNSDT
VFLEAPYEHMRKWLENVPNDGLIRYYVSINLERILPVGPRALKEILVTKSYDFPKPEFIRASLKRLAGEH
GLLLVEGDDHKKSKKNLLPAFAYRHVKEMYPIFWSKSIEMVRVMDEDLRKKADPTDNVLRMGAYASRAAL
DIVGVAGMDHDFQSLRDPNNKLVRTYQNLMSEPPLYMKIIFLLTLLLGDPAVVHDLPLERNRSIERSSET
IRDVARQMIRQKRAKWESGSSTAEDIDIVSVALRSGNFTEEELVDQMMTFLGAGHETTSTALQWCVYVLC
KHPDVQTRLREEIRANLPPISTENPQPPAATDIDNLPYLNAVCNEVLRYHPSVPATIRCASRDTTIIGEP
IPKGTLFLIAPEIIGKSKELWGPDADKFNPERWLGPGRANNGGADSNYANLTFLHGPRSCIGQGFAKAEL
ACMVAVVVGKYHMELKNPNAPLEIRQQATVCPKDGVLAKFTNIEGW
CYP617D4 Aspergillus flavus
100% to CYP617D4 Aspergillus oryzae
See fungal pages for seq
CYP617D6 Aspergillus niger
JGI gene model e_gw1.4.269.1|Aspni1
61% to CYP617D2
See fungal pages for seq
CYP617D7 Aspergillus clavatus
77% TO CYP617D5
See fungal pages for seq
CYP617D8 Aspergillus clavatus
78% TO CYP617D2
See fungal pages for seq
CYP617D9 Aspergillus terreus
64% to CYP617D4
See fungal pages for seq
CYP617D10 Grosmannia clavigera
CYP617E1 Aspergillus fumigatus Af293
GenEMBL XP_753139.1 also EAL91101.1
45% to 617C1, 36% to 617A2
MISFLGLWLCTVTLASGGIFHQALAGGEHTALHFQVLGAHVVAFVAFAVYW
MILYPRYFTPFGNIPTPSRRRILTGNYPVLFPDNAWVPLRELAETTPNDGLLRIYSALSGEALLVTSPPA
IRDMLTVNAFDFTHQDLVKIAIRRFTGSNLERTQLHRKNMMPAFTVPHVRKLTSIFWAKAQEMVRCMSNE
LRADSFARIDFREYMSRATLNNIGLAGMGHDFQTLKQPDTDLRSHHRKLILDPTRVFSWVGLLSRYFDMR
LLMRVPLKKLIEISQSAKYLRELTTAVIQGRREQLVVAENNRGKDIITVALAGGVFDEHHLVDHVMTFLT
AGHESTATAFEWTMYELGRRPEMQSRLRDELRATIGTDLAAVNFGLRVQNLPYLNAFCSEVLRCYPFSPI
IVKVAQKETMLIGQRIPKGTVVLYSAEVSNHDKTLWGPDADKFDPERWMGAKKAKSGGASSNYAMLTFGA
GPRNCIGANFARATLECLVAAVLSTFEIELANPDTAGRLKFGQTKKSAEGIYGRLKFVQPVEV
CYP617E2 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_100429|Aspni1
80% to CYP617E1
See fungal pages for seq
CYP617E3 Aspergillus clavatus
77% to CYP617E2
See fungal pages for seq
CYP617F1 Gibberella moniliformis (also Fusarium verticillioides)
AF155773.4
fumonisin biosynthetic gene cluster,
FUM15
46% to 617A1, 43% to 617B1, 42% to 617D2, 37% to 617C1, 32% to 617E1
possible GC boundary after GNRE to remove short intron before heme
signature (lower case seq)
MRGLNNIAVALALSAIWSFGLDLGRHGTSGSSLLLALFRTLCKA
YPFVVISHFVWSAIIWPTFFSPLRQLPNVPSDGWLSKETLRLVSEPRGVPQSDWINSL
SNRPVDLARYRSFLGFERLLIISPKALAEVLTTKSYDFRKPGLIVSELKQATGMGVLL
AEGSEHKSQRKALQTAFNYRHIKNLYPVFWDVAGEFATVLEKQIPTGTPRTSDTTAVI
DIVDWASRATLDIIGRAGMGQGFDAIQNDDSRLHQAYRMIFEPSRGAIFLALLRLIFP
ERLVNWLPLRRNKRMRHGIQVIRSKCQELIRERKEKIKRQKAGVDNSGNDILTVALLN
GVFTDEQLIDQLMTFLAAGHETTATALTWAIYILCKQPEVQNRLREEIRMHFPNPKGW
PRSERPSSNTLQQAIDFKLPYLNVVCLEVMRYFAPIPLTMREATCDTTILHTFVPAGT
RIILAPRVTNRDSALWGPDANNFNPDRWLSPKNGNRE (0)
ateqskfkignqkrdstaapevtqeevrgrte
ARSNYADLTFLHGPRSCIGQSFARVEFAILLATLIANFEFQIEDESL
LDERNISISRGATSRIVGGLKVRVRPIAVV
CYP617F2 Aspergillus niger
JGI gene model e_gw1.1.329.1|Aspni1
54% to 617F1
See fungal pages for seq
CYP617G1 Mycosphaerella graminicola
50% to CYP617A1 Fusarium graminearum
See fungal pages for seq
CYP617G2 Mycosphaerella fijiensis
JGI gene model e_gw1.1.212.1
61% to CYP617G1 Mycosphaerella graminicola
See fungal pages for seq
CYP617G3 Metarhizium anisopliae var. acridum Ma102
CYP617G3 Metarhizium anisopliae var. anisopliae Ma23
CYP617H1 Uncinocarpus reesii
48% to CYP617D3
See fungal pages for seq
CYP617J1 Fusarium oxysporum
51% to 617A1
See fungal pages for seq
CYP617J1 Fusarium verticillioides
90% to CYP617J1 Fusarium oxysporum
See fungal pages for seq
CYP617K1 Aspergillus clavatus
50% to 617D2 Aspergillus fumigatus
See fungal pages for seq
CYP617L1 Aspergillus clavatus
47% to CYP617A1 Fusarium graminearum
See fungal pages for seq
CYP617M1 Metarhizium anisopliae var. acridum Ma102
CYP617M1 Metarhizium anisopliae var. anisopliae Ma23
CYP617N1 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-6
50% TO CYP617A1 Fusarium graminearum
CYP617-un1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_21000071
Necha1/scaffold_21:299839-300774
pseudogene possibly derived from CYP617A2
37% to 617A2 mid region aa167-258, 33% to 617C1
36% to CYP5070A1 Aspergillus oryzae
See fungal pages for seq
CYP618A1 Fusarium graminearum
FG03961.1 AACM01000168 FGcontig1.168_scaffold2
See fungal pages for seq
CYP618A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.35.9.1
Necha1/scaffold_35:311438-313183
63% to 618A1, probable ortholog
See fungal pages for seq
CYP618A3 Fusarium oxysporum
73% to CYP618A1
See fungal pages for seq
CYP618A3 Fusarium verticillioides
87% to CYP618A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP619A1 Fusarium graminearum
FG09086.1 AACM01000370 FGcontig1.370_scaffold6
See fungal pages for seq
CYP619B1 Aspergillus nidulans
AACD01000084
See fungal pages for seq
CYP619B2 Aspergillus nidulans
AACD01000105
See fungal pages for seq
CYP619C1 Aspergillus terreus
CH476602
This P450 is two genes away from MSAS polyketide synthase
6-methyl-salicylic acid synthase used in patulin synthesis
patulin is a mycotoxin sometimes found in apple juice.
51% identical to CYP619B2, 39% to CYP619A1
MSKWAKQYGGIFSLKRFRNTTIVLTDWKIMKELVDKKSTNFSHR
PPSKVADLITRGNHILMMQYGETWRTMRKLIHQYLMESQCEKEHWKVQEAEAAQMLHD
FLVDPENHMKHPKRYSNSITMSLVFGIRAKSVNDEYMTRLYSLMEKWSLVLETGATPP
VDSWPLLQWIPERFMGYWRRRATEVGDLMTGLYTEVLHVIENRRKAGIYKDSLMDRVL
DKKDKYRFDEHQLAFLGGTLMEGGSDTSSSLILAIVQAMTQYPEVQKKAHAEIDSVIG
TDRSPAWSDFRKLPYINMMIKEAHRWRPVLPLGVVHGLATDDSYNGMHLPKHSTVILN
VWGMHMDPDRFENPDAFIPERYANFPELAPHYAALADGAARDHFGYGAGRRICPGIHL
AERNLFIAVAKLLWAFEFKNNPAGKNDASAETGSSQGFMHCVKDYDAIVTVRGEERRQ
TILRELEQAQTVFAKYD
CYP619C2 Aspergillus clavatus
EU678354
Olivier Puel
Submitted to nomenclature committee April 28, 2008
65% to CYP619C2
MDFTQVPPSYILGVLLSSTSILFCLKYLLRSGYRPPELPSGPTT
VPLFGNELQVPKADAHFQFTKWAKQYGGMFSLKRYMNTTIVITDRKLMKSLLDKKSNI
YSHRPASLVSHLITQSDHLLVMQYGEEWRMLRKIIHQYFMEPNCEREHWKVQEAEAKQ
MLHDFLTMPEDHMLHPKRYSNSITNSLVFGIRTATVHDEYMDELFYLMDKWSLVQELG
ATPPVDSFGLLRILPQWMLGNWKNRAVEVGDLMQALYSKVLDQVRARRQRGVYRDSFM
DRVLDNLEKTPLTENQLRFLGGVLMEGGSDTSSSLILTIIQAMTKYPEVQAKAHAQID
AVVGSERSPSWSDFAQLPYINMIIKESHRWRPVSPLGVPHAVAEDDRVNNTLIPKGST
IVLNVWGMHHDPDRWSEPEHFQPDRFADYPALASTYAASGEWDKRDHYGYGAGRRICP
GIHLAERNLFIGVAKLLWAFEFSEPLGSRSDISAESGASQGFLHCPKDYGCAIRLRAP
EKRETIMREFEEAQGVFSRFD
CYP619C3 Aspergillus clavatus
EU678353
Olivier Puel
Submitted to nomenclature committee April 28, 2008
55% to CYP619C1
MEPMLLLILVAAVVLLFVRWAFVYGHRTSNMPKGPPTLPFIGNI
HQIPTQYTHIKFTEWAAKYGGLYMLKVGNGNMAVVTDRRLVKEVVDRKSGIYSHRPHS
FVSHELITKGNHLLVMHYGDQWRTFRRLIHQHLMESMVDSQHVKIVNAEAIQLVRDYL
VDPEHHMAHPKRFSNSITNSIVFGIRTADRNGSNMKRLYKLMEEWSEIMETGATPPVD
LFPWMKMLPQWMFSNYVNRAKAIGVQMETLYTDILNKVIKRRNGGQNLGTFMDRVLDG
QEKNDLPWHQLAFIGGVLMEGGSDTSSSLTIAIVQALILNPAVQKKAHAEIDAVVGSD
RSPVWEDLEKLPYINMIIKEGHRWRPILPLCFPHALGEDDWVDGKLLPKGTVVVINTW
GMHMDPSQPDDPAAFIPERYANHPQLAPEYAAGKWENRDHYGYGVGRRICPGIHLAER
NMFLAIAKLLWAFEFQRGGGKIDSDPVTGYHNGFLYCAKDYPCRPVVRNKTIRATIER
EFATATKEVFSQFTEG
CYP619D1 Aspergillus niger
JGI gene model gw1.16.300.1|Aspni1
50% to CYP619B2
See fungal pages for seq
CYP619E1 Metarhizium anisopliae var. acridum Ma102
CYP619E1 Metarhizium anisopliae var. anisopliae Ma23
CYP620A1 Fusarium graminearum
FG02837.1 AACM01000142 FGcontig1.142_scaffold2
See fungal pages for seq
CYP620A2 Fusarium oxysporum
76% to CYP620A1 Fusarium graminearum
See fungal pages for seq
CYP620A2 Fusarium verticillioides
84% to CYP620A2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP620B1 Fusarium graminearum
FG03700.1 AACM01000161 FGcontig1.161_scaffold2
See fungal pages for seq
CYP620B2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_19000072
Necha1/scaffold_19:183528-185225
56% to 620B1 Fusarium graminearum probable ortholog
See fungal pages for seq
CYP620B3 Fusarium oxysporum
82% to CYP620B1 Fusarium graminearum
See fungal pages for seq
CYP620B3 Fusarium verticillioides
97% to CYP620B3 Fusarium oxysporum
See fungal pages for seq
CYP620C1 Fusarium graminearum
AACM01000001.1
See fungal pages for seq
CYP620C2 Gibberella moniliformis = Fusarium verticillioides
GenEMBL AAIM01003167.1, DR662816.1 EST
50% to 620D1, 51% to 620B1, 54% to 620B2
2136 MLSAVLILVGVALTILYIRTKPRKNLPPGPKPLPILGNVKDMPDGTIPEYQHWIKFK 2306
2307 DLYGSISHVSVLGQSLIILHDRQAANAILEKTSTKTSGRPQFVFGNEMCGYNQILPFKPY 2486
2487 GKLLKQHRKLVHQQLGTKTAASRFRDVLDVESRRLLLRILETPEKLFEHIQT (2) 2642
2695 EASAIILKMTYGYSLEPRKPDPLALLIEQMMHNFSLAFVPMSWPVDVLPILRYLPESLPGM 2877
2878 SFKRIAREWNANMRMVVDVPYTFVKRQIAKQSNRPSYVSSLIKQHDDDMDEETDAAIKQT 3057
AAVMYAGGSDTTVSAICGFVLAMLLFPEVQRKAQQEIDSVVGTERLPQFEDRDNLPYVDALTKESL
RWIPVAPMGAVHTADEDIHYKDFVIPKGASLLPATWWFLHDPEIYSDPTSFDPDRYLEPR
NEPHPNFASFGFGRRVCPGRFLADESLFISISRLLAAFEIKKAVDGRGNEIEPQISVTPG
LISHIRDFPYDIEPRSEKYAAMMRQVEDDHPWEQADATFLNMDGSLESEKV*
CYP620C2 Fusarium oxysporum (temp CYP620C3)
83% to CYP620C2 Gibberella moniliformis
See fungal pages for seq
CYP620C3 Metarhizium anisopliae var. anisopliae Ma23
CYP620D1 Aspergillus nidulans
AN3394.1 47% to 620B1 64 clan
See fungal pages for seq
CYP620D2 Histoplasma capsulatum G217B
ABBT01000228.1 Ajellomyces capsulatus G217B
73% to CYP620D1 but N-term is not detected
HCB07277.1 (fusion to another protein)
Upper part of fusion protein seq is
alpha 1,2-mannosyltransferase (deleted)
See fungal pages for seq
CYP620E1 Aspergillus nidulans
AN1601.1
43% to CYP64A1 64 clan
65% TO 620H3 name needs revision 620H3 = 620E4
revised 7/18/07
MAPTAILITVPLGLLLYLLFIRPSIAKKQKAPLPPGPPPKPLIGNLRDLP
SPDQKNWVHFLQHRDLYGPISSLTVFGQTIVILNDARVAFDLLEKRSNIY
SSRPRMVFAGEMVGWEHILAMQPYSDMFRAYRKAMHRVLGTKNVIAQFNE
LQDVEARRFLLRVLEKPGDLVQHIR (2)
TETGAVILKIA
YGYDIEPHGKDPLVALANESLANFAVAGTPGAWIVDTIPF
MKYLPSWFPG
TGFKRTAASWKQTLLTTIEKPYRLVLKQLESGKYPDSYLSNLLEETKGRP
LSADEEQVIKWTAGSLYTGGADTT
TVSTLSCFFLAMALYPDVQRKAQEE
LDTVLGSAKLPTFGDRARLPYIEAIVKEALRWHPVAPMGIPHMSTEDDIY
EGYLIPKNSLIMPNIWAFTHDASHYKDPATFNPSRFLGDTPEPDPSTLTF
GFGRRICPGRLLADSSIFLTIAQSLAVFEISSAGEDAAKAEFLPGVISHP
VPYRLDIRPRSKGHEDLVKRIAAESPFGEGGAKELEEIVV*
CYP620E2X Aspergillus oryzae
GenEMBL AP007164.1b, BAE62129.1
second P450 of six on this accession
renamed CY620H4
CYP620E3 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_24000005
Necha1/scaffold_24:11514-13534
51% to 620E1, 43% to 620A1 Fusarium graminearum
43% to CYP64A1 Aspergillus flavus
48% to CYP5037B1 Lentinula edodes (Shiitake mushroom)
[overlap of families, may need revision]
See fungal pages for seq
CYP620E4P Fusarium oxysporum
64% to 620E3, end badly frameshifted
See fungal pages for seq
CYP620E4P Fusarium verticillioides
84% to CYP620E4P Fusarium oxysporum = ortholog
See fungal pages for seq
CYP620E5 Aspergillus oryzae
GenEMBL BAE55186.1
55% to 620H1, 56% to 620H4 65% to 620E1
formerly CYP620H3
revised 3/17/2009
MPLPTLGSVLLGLAFLYFVKLVLLRKKTLAPLPPGPKPKPIIGNLRDLPRPGQQEWTHWLKFKELYGPIS
SVSMFGQTIVILNDHQAAFDLMEKRSAIYSSRPRLVFAAEIVGWEDVITLQGYTNRFRSYRKAMHRVLGT
KELMSRFNPLQDVEVRRFLLRILQKPDELIQHIKTEVGAVILKIAYGYNIEPHGRDPLIDLVNDSMENFS
AVVKPGTWLVDVIPLLKYLPTWFPGAGFKRTGYEWRKTLLATIEKPYQLVKQHMRQGSYPPSYLARLLEQ
IDGEPTAEEELVSKWTAGALYAGGADT
TASSLSSFFLAMALYPEVQRKAQKEIDRVVGPNKLPTFED
RDTLPYIDAMVKETLRWHPVGPMGVAHLVTEDDIYEGYLIPKGALILPNIWGFTHDPKIYRDPETFRPER
FLGDNPELDPHTLAFGFGRRICPGRLLADATIFLTIAQSLTVFNFSKPEGEGDLKAEFLPGVISHPAPYR
LEITPRSAAHEALIRSVEVEHPWEESHAKELEKVEC
CYP620E5 Aspergillus flavus
99% to CYP620E5 Aspergillus oryzae
See fungal pages for seq
CYP620E6 Aspergillus clavatus
63% to 620E5, 61% to 620E1 (subfams 620E overlaps with 620H)
See fungal pages for seq
CYP620E7 Aspergillus terreus
55% to CYP620E5
See fungal pages for seq
CYP620E8 Aspergillus terreus
72% to CYP620E5
See fungal pages for seq
CYP620F1 Aspergillus fumigatus Af293
GenEMBL XP_747154.1
O-methylsterigmatocystin oxidoreductase predicted
46% to 620D1, 48% to 620B1, 44% to 620C2, 38% to 620A1, 38% to 620E1
MAYELSTLQLSCVAFVAFMAVLVFRTRTRNLKQNVPPGPRPLPIIGNFFDLPPKGQPEYLHWFKHKDAYG
PVSSINVMGTTLVIFHDKDAAHAVMGKKAQKTSARPQLNFAQLCGFENFLITHQYNDKYRLHRKMVHQEI
GTKGLSAGFRPIQEQESIRFILQTFNRPDDILQHLKTLAAAIVLKITYGYSIERKGQDPLVELIEHAMEN
LSQAFVPLAWAVDSVPAIKYLPDWFPGMSYRKTARKWRAINEAAAELPYDFVKRQMAHKAHQPSYVSNLL
EKHMIKSEDNKINVSAADEEAIKWTAVSLYAAGSDSTVAIIHSVICGLVMFPEVVTRAQEEIDRVVGSDR
LPNFDDRTNLPYVDGIIKEAWRWNPVGPMGLTHKSEEDLVCGEYLIPKGSYLLPSLWWFLNDPKEYPEPR
VFKPERYMEPFNHPDPSEIAFGYGRRSCAGRYFADASVYITVVQLLAVFNVRKARDDQGNEIPVTLQAIP
GMVNRPAPFQFKVEPRSQHHIDLLRRIESEQIPEVSHASLLKPSTV
CYP620F2P Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pm.C_10155
62% to CYP620F1
See fungal pages for seq
CYP620F3 Metarhizium anisopliae var. anisopliae Ma23
CYP620G1 Aspergillus oryzae
GenEMBL BAE59625.1
52% TO 620H3, 48% to 620H4, 46% to 620E1
MMYTLSTLVFLAGILGLYVLLNSKAPRAPLPPGPKGLPIIGSVGSDLPRGGRDWEHWLKHKELYGPISSI
TTAGHTHIILNDANVATELLEKRSARYSSRPRLVMANELSGSDIFVTTQNEHAIVRALRKRILSQLRSEE
VLLSFYPQVDTLIRRFLLRTLQKPEELIGNIKTGIGGVILKVVYGYTVEFHDRDPLVDLVGETAVAFGRI
NQPTGYLVDSIPAPLSVKYLPSWFPGAGFKKEAREYRRGFDTLLNWPFTFARRQMEEGNYEPSFVSRLIE
QRGSLLSLEEEVKIKHAAAAVYQAGYDTTASTITSFFLAMALFPAAQHKAQEEIDRVVGARLPTPEDRGK
LPYVNALINEVLRWNPVAQIGIMHAATEDDIYEGYLIPKGAPIVPNIWAIAHDPDVYSDSMSFKPERFLA
SDGHTPERDPHTLVFGFGRRICPGRPLTDFNNFLTIARSLAVFQVQKATKDGKEIDPIVDYQGGIIGHLS
PFEVSIRPRSAEHEALIRSIEVEDSISRGDSAALESVRV
CYP620G1 Aspergillus flavus
98% to CYP620G1 Aspergillus oryzae
See fungal pages for seq
CYP620G2P Aspergillus niger
JGI gene model gw1.10.879.1|Aspni1
60% to CYP620G1 partial C-term seq Pseudogene
See fungal pages for seq
CYP620H1 Aspergillus oryzae
GenEMBL BAE60302.1
69% to 620H2, 53% to 620H4, 49% to 620E3,
48% to 620G1
MMLVVSLLLGLTGLYIIRWTLGERKTLKRLPPGPTSKPVIGNLLDLPSPGTPDWLHWLKHKELYGPISSV
TIFGQTIVILNDRQTVIDLMEKRSGLHSSRPQLPIAEITDWDDTLGLIPYNSRFRAYRKALHQEMGTPAS
ILKYHDIIDMETHRLLFRILENPEDLVQHIRKEAGSIILRVGYGYVTEPHARDPLVDLVDKAMEDFSQLV
LPGAWLVNFIPMLKYLPSWFPGNGWQETAKAYKKRVTAMRDVPYTFVQRQIKKQNHVPSYVSSLLEQGNV
EPGSEEEIVAKWSAQSLYGGGAETSVSSLACFFQAMVLNPNVQKRAQEEIDRVVGTSRLPDMSDRENLPY
INAVVKEVLRWHPVTPLGVTHAASEDDTYNGYFIPKGSILVSNIWAIAHDPELYHDATEFKPERFLGVNG
RTPEYDPHLLSFGFGRRICPGQHLAAANLYLAIARSLAVFDITHLVKNGKEVPVTPEFTTGIISHPAPFE
LSIRVRSPEHEKLIRAVEKSYPWEKSHAEELQLKI
CYP620H1 Aspergillus flavus
99% to CYP620H1 Aspergillus oryzae
See fungal pages for seq
CYP620H2 Aspergillus oryzae
GenEMBL BAE61267.1
69% to 620H1, 49% to 620H4
MLVLVSLVLCLTGFCLLQWALKERKIVKGLPPGPRPKPIIGNLLDLPPPGALDWLHWLKHKELYGPISSV
TIFGQTIIIINGHRVANELMEKRSGVHSSRPHVPIAELAGWQYTLGFIPYDSRLRAYRRALHQEMGNATS
ISKYHNILDMETHRLLFRILKTPDCLMQHLRKEAGSIILRITYGYITEPEAYDPLIDLVDKAMEDFAQVI
LPGGWLVNFIPMLKYLPSWFPGCDWQRRAKAFKQRAKAMTDIPYAFVKQQHEQQKHIPSYVSRLLEQNNI
KLGSEEELVVKWSAQSIYGGGAETSVSVFACFFQVMALHLNVQKKAQEEIDRVVGASRLPDLSDCKNLPY
INAVVKEVLRWHPVAPMGVAHASSKEDIYHRYVIPKGAILVPNIWAMAHDPDFYHNAMDFEPERFLKSGR
NEQNPEYDPHQFIFGFGRRTCPGQHLVSANLSLGVARVLAVFNITNAVRDGKKVPISPEFSPGVISRPAP
FELSIQVRNAECKRLIEAVGMKFPWEESHAEALAQLRI
CYP620H2 Aspergillus flavus
99% to CYP620H2 Aspergillus oryzae
See fungal pages for seq
CYP620H4 Aspergillus oryzae
GenEMBL AP007164.1b, BAE62129.1
second P450 of six on this accession
complement(join(1111497..1111884,1111943..1112214,
1112271..1112515,1112568..1112719,1112780..1112971,1113193..1113425))
53% to CYP620E3, 50% to 620E1,53% to 620H1,
56% to 620H3, 49% to 620H2, 47% to 620G1
formerly CY620E2
MASLHLASIAIGVLTAYLLTKLLTFKKPPAPLPPGPPPKPIIGN
LKDLPQNGERDWEHWLKHKELY (1)
GPISSITVLGQTFIILNDQKLAVELLEQRSKWHSDRPKMFFAAEM (2)
SGCGGILGLIPYSDRSRAIRKAMN
KEIGSKVAVSRFNALQEAETRRFLLRVLEAPEELRNHIRTEAGAVVLKLAYGYTVEPH
KQDPLVDLADVSMYYFSLVCRYGAWVVDVFPSLRFLPSWFPGTEFKRIGQRSKEAFDN
FGGKPYNFVKHQMSQGTHHPSYLSSILESEEIEPGSEKEYVTKWSAASIYAGGADTTV
STMASFFLAMALYPEAQRKAQEEIDRVVGNSRLPTFADRDNLPYINATVKEVLRWHPV
VPNNLPHLSTHDDMCQGYFIPKGSIVISNIWGFAHDPDVFHDPMTFKPERYLGDNPEP
DSHRISFGFGRRICPGRVMADAAIYLNIAQSLAAFNIGKKVVDGKEVEPRVEFQAALI
SHPEPYDVSIKPRSSVHEELIRAVEEEYPWEKSHADELVNIKV
CYP620H4 Aspergillus flavus
99% to CYP620H4 Aspergillus oryzae
See fungal pages for seq
CYP620H5 Aspergillus niger
JGI gene model e_gw1.10.144.1|Aspni1
59% to CYP620H4
See fungal pages for seq
CYP620H6 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_4000144|Aspni1
60% to CYP620H1, 41% to CYP64A1
See fungal pages for seq
CYP620H7 Aspergillus niger
JGI gene model e_gw1.1.1438.1|Aspni1
53% to CYP620H1
See fungal pages for seq
CYP620H8 Aspergillus niger
JGI gene model e_gw1.6.1233.1|Aspni1
54% to CYP620H3
See fungal pages for seq
CYP620H9 Aspergillus oryzae
GenEMBL BAE60640.1
58% to 620H7, 56% to CYP620H5
revised 3/18/2009
formerly CYP620J1
revised 3/18/2009
MSYMVLGLAIGVIFLYFIRSFLARTKSFAPLPPGPRPKPIIGNLWDLPPQGTRDWLHWLKHKDLY
GPVSSVTVFGQTIIILNEARLAYELLEKRSAIHSSRPSCTFAHM
AGYGDIMTILEYSERLRT
TRKVAHQQIGSNKAISRFSHIQDAEVCRYLLRMLRDPGNWLEHIKKQVETGAVILKITYGYTVEPHGRDP
LVDLAEDAVGKFSLAMVPGAWLVDSIPI (1)
LRHLPSWAPGGGCTRAAEGFQTAARNLGNVPYA
FTKQQMTQGSNVPSIISYYLESENIQ
PGSEEEHLVKWATATLYGGGADTTVSTMMCFFLTMALYPHVQRKAQEEIDRVVGATRLPGFEDRGNLPYI
DALLKEALRWHPIVPMGVAHMAMEDDMLEGYRIPKGAAILSNIW
AFTHDPNEYHDPMTFKPERFLSDNGHTPERDPHLLAFGFGRRVCPGRNLADSNLWLTIARTLAAFNIAKPIRDGKEVD
IQPEFQAGLISHPEPFDVDIKLRSAGHHELILAGEKQYPWEESHAEELRRAIAVL
CYP620H9 Aspergillus flavus
57% to CYP620H7, 98% to CYP620J1 Aspergillus oryzae
See fungal pages for seq
CYP620H10 Aspergillus oryzae
GenEMBL BAE64937.1, AP007171.1
51% to 620H4, 51% to 620H3, 43% to 620E1
14 P450 genes and 2 pseudogenes on this contig
revised 3/18/209, formerly CYP620K1
MESILLFLTISLVGLYLVGSHLSKKHSLGHLPPGPPRKPIIGNLTDLPSHDVCDWEYWLKHKDLY
GPISSLSIFGDNIVILNDARFARDILEKRSSIWSSRPSWNFGKM
AGWNKILGTLAYSDPSFKDMRKAIGHQIGSKTAASRFN
AVQDLEVRRFLLRVLEDPDNLLQHIRK ()
EAGAIVLKIAYGYTIEPHGHDPLVDLADEAMATFGLAILP
GTWVVDFIPILKHVPTWFPGAQFARMAKQFRKSAAAFSDVPYAFVKRRLAQRDFEPSFLAGLIRKNEEQP
GPGSYEETVIKWAAASFYGGGSDTTVSTMSSFFLVMAQYPHVQRKAQAGIDCVVGPDRLPSFQDRENLPY
IYAMVKEILRWHPVLPMGTAHASVMDDTYEGYTFPKGTLMVPNVW (2)
AFTHDPSTYPDPHTF
KPERFLSYEGHEPEANPYYLVFGFGRRVCPGRTLADANLYISIAQSVAAFTITKPIRDGKEVDLRAEYQS
GAISHPVPYNVTITPRSPRYEELIRAVETEHPWEKSHSEELRLV
CYP620H10 Aspergillus flavus
99% to CYP620H10 Aspergillus oryzae
56% to CYP620H5, 57% to CYP620H9
See fungal pages for seq
CYP620H11 Aspergillus terreus
58% to CYP620H5
See fungal pages for seq
CYP620H12 Aspergillus carbonarius
FD661712.1 EST
81% to CYP620H5
TFAGGADTTVSSISSFFLAMALFPEVQRKAQEELDAVVGTNRLPQYEDREQLPYINALVKEVL
RWHPVVPMSLAHTPIKDDTIEGYSIPKGATVLANIWELVKQSN
CYP620L1 Fusarium oxysporum
51% to CYP620E3 Nectria haematococca
See fungal pages for seq
CYP620L1 Fusarium verticillioides
87% to CYP620L1 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP620M1 Mycosphaerella fijiensis
JGI gene model e_gw1.22.354.1 revised
45% to CYP620E1 Aspergillus nidulans
44% to CYP620H5 Aspergillus niger
See fungal pages for seq
CYP620N1 Metarhizium anisopliae var. acridum Ma102
CYP620N1 Metarhizium anisopliae var. anisopliae Ma23
CYP620P1 Metarhizium anisopliae var. acridum Ma102
CYP620P1 Metarhizium anisopliae var. anisopliae Ma23
CYP620Q1 Metarhizium anisopliae var. acridum Ma102
CYP620Q1 Metarhizium anisopliae var. anisopliae Ma23
CYP621A1 Fusarium graminearum
NW_059885.1 72462-74811 (-) strand
Locus tag FG05113.1
AACM01000205 FGcontig1.205_scaffold3
I propose a 1 nucleotide MICRO exon agggt for the joint At PK/G/TVV
This is needed to preserve the length and seq in this joint
The phase (1) and phase (2) boundaries do not fit otherwise.
See fungal pages for seq
CYP621A2 Nectria haematococca (Fusarium solani group)
Gene model e_gw1.5.1476.1 at JGI, Necha1/scaffold_5:782235-784633
66% to 621A1 , 79% to AAIM01001458 Gibberella moniliformis
I propose a 1 nucleotide MICRO exon agggt for the joint At PK/G/TVV
This is needed to preserve the length and seq in this joint
The phase (1) and phase (2) boundaries do not fit otherwise.
See fungal pages for seq
CYP621A3 Gibberella moniliformis = Fusarium verticillioides
GenEMBL AAIM01001458 5016-7344
79% to 621A2 probable ortholog
I propose a 1 nucleotide MICRO exon agggt for the joint At PK/G/TVV
This is needed to preserve the length and seq in this joint
The phase (1) and phase (2) boundaries do not fit otherwise.
See fungal pages for seq
CYP621A3 Fusarium oxysporum
AAHX01000542 41682-44101 (+) strand
93% to CYP621A3 Gibberella moniliformis
I propose a 1 nucleotide MICRO exon agggt for the joint At PK/G/TVV
This is needed to preserve the length and seq in this joint
The phase (1) and phase (2) boundaries do not fit otherwise.
See fungal pages for seq
CYP621B1 Aspergillus clavatus
42% to CYP621A3
Supercontig 76: 1359064-1360557 (-) strand no introns
See fungal pages for seq
CYP621C1 Metarhizium anisopliae var. acridum Ma102
CYP621C1 Metarhizium anisopliae var. anisopliae Ma23
CYP621C2 Grosmannia clavigera
CYP621D1 Grosmannia clavigera
CYP622A1 Fusarium graminearum
FG08187.1 AACM01000329 FGcontig1.329_scaffold5
See fungal pages for seq
CYP622A2 Fusarium oxysporum
84% to CYP622A1
See fungal pages for seq
CYP623A1 Fusarium graminearum
FG02117.1 AACM01000111 FGcontig1.111_scaffold1
See fungal pages for seq
CYP623A2 Fusarium oxysporum
82% to CYP623A1
See fungal pages for seq
CYP623A2 Fusarium verticillioides
93% to CYP623A2 Fusarium oxysporum
See fungal pages for seq
CYP623B1 Fusarium graminearum
FG09195.1 AACM01000371 FGcontig1.371_scaffold6
See fungal pages for seq
CYP623B2 Aspergillus nidulans
AN3497.1 53% to 623B1 54 clan
See fungal pages for seq
CYP623B3 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.12.604.1
Necha1/scaffold_12:172258-173956
60% to 620B1 Fusarium graminearum probable ortholog
See fungal pages for seq
CYP623B4 Gibberella moniliformis = Fusarium verticillioides
Genomic seq = AAIM02000051.1 PKS ortholog to PGL1 starting at 437510
There is a CYP623B4 seq at 468-470k 72% to 623B1
94% to 623B4 Fusarium oxysporum
470403 MPYTAE
470385 LGLLARVVSPLGIASIVVIGVIAIYVIDKLTSVPYPPDIPLIREQKGARRFSLRTRWAYL 470206
470205 TDCQALFYEAYHE (0) 470167
470120 YLKKGKPVVIPGFGVRIEVLLPHSQMKGVLNQPEDVLDMEQAFAEVDQVRWSLGHEKYV 469944
469943 VDAWQGLVVKYDLNRAIEIIANNMKDELHEVFDEQFGTDTENWRRIDLTKTVKMIVAQAA 469764
469763 SRFTVGLPLC(2?)
RNKEYLNLALEMNDLFIMNAGLTG (1?) 469584
469583 GTLFGQIVNTKVNKMKKWIMPLLKHRFDRINNHPDEPQPQDQVQMMINYALRHRQHEVND 469404
469403 MESLARRVVAQNFGSIHNTQIQIVNLILNVLGSDAEFNTIATLRDEMDRILGTDDSVNWT 469224
469223 KSGIQAMTRADSVARESIRLCSFGGRAVFRKVMVDDFKTEDGHHVPKGSIISFMGHPAQT 469044
469043 DNEFYEDGLKYDPFRFSRIRETAASRDETAPPVTFVTTSPEFLTFGHGKHACPGRFLIDF 468864
468863 EMKMILAYALRNYDIKLADEYEGKRPPNYWIAEANNPPSGVQIMVKRRERK* 468708
CYP623B4 Fusarium oxysporum
AAXH01000338.1 cont2.338,
PKS ortholog to PGL1
This is the next contig after cont2.337 which has a pks seq at the end
About 31kb away
CYP623B5 = 73% to 623B1 probable pigment modification of pks product
Formerly CYP623B5, 94% to 623B4 Gibberella moniliformis
33080 MSSSAELGLLARLPSLASPLGIASIVVIGVIAIYVIEKLIGVPYPPDIPLIREPKGARR 32904
32903 FSLRTRWAYLTDCQALFYEAYHE (0?) 32835
32788 YLKKGKPVVIPGFGVRIEVYLPQSQMKGVLNQPEDVLDMEQAFAEVDQVRWSLGHDKYV 32612
32611 VDAWQGLVVKYDLNRAIEIIANNMKDELHEVFDEQFGTDTENWKRIDLTKTVKMIVAQAA 32432
32431 SRFTVGLPL (1) 32405
32355 CRNKEYLQLALETNDLFIMNAGLTG
GTLFGQIVKTKVNKMKKWIIPLLK 32179
32178 HRFDRINNHPDEPQPQDQVQMMINYALRHRQHEVNDMESLARRVVAQNFGSIHNTQIQVV 31999
31998 NLFLNVLGSDAEFNTIATLRDEMDRILGTDDSVNWTKGGIQAMTRADSVARESIRLCSFG 31819
31818 GRAVFRKVMIDDFKTEDGHHVPKGSIISFMGHPAQTDNELYEDGLKYDPFRFSRVRETAA 31639
31638 NRDEKAPPVTFVTTSPEFLTFGHGKHACPGRFLIDFEMKMILAYALRNYDIKFADEYEGK 31459
31458 RPPNYWIAEANNPPSGVQIMVKRRERT* 31375
CYP623C1 Beauveria bassiana
AM409327
Chembiochem. 2007 Jan 11;8(3):289-297
Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus
Beauveria bassiana. Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey
AM, Lazarus CM, Simpson TJ.
Gene name tens2
MALFQAMSMVAQLGYYEKVAGVLGFLSIALLFWKLNHKPFYPAL
PLAGEPPQRRWFSLSNRLRYYNDCAALFDEAYHTAYAKKGKAVLVPSMGVHTAMIMPE
SAMNWAMSQPDDSLSIKKAFSELNQTKYSLGHGRYWEDPWQLDLVKAHLSSILQNLIP
QLNEELAAAFSKHLGTDAENWKEIELEVIMRRIIAQATSRFIVGLPLCRDDGYLDLSY
KVILGMVTTIWATLPFPDLIRAITGPIASWQTRRNIARIQEYLEPLYQERISILESRD
GPESDPEPQDLFMMMLRFAQKKRPDEYANLGIMTRRVCAANFVAMHQSTVSVTNLILN
IIGSDAEFNTTATLRDEITQVMRGTDAKSWTKDTFTRMRKCDSVAREAMRLNFPLGTR
GSMRAVLKDGLESPEGIKLQKGTTISWLASCAQVDADRFDNPQKFDPFRFSRASKDDD
DDGKSTSSHAKDAFVTTSPQYLPFGHGKHACPGRFMVDLMFKILLAQLLTHYDLGWPE
DYQGKQPPSVWQGELSEPPPGARILVKRRKV
CYP623D1 Histoplasma capsulatum
45% to CYP623B3
See fungal pages for seq
CYP623E1 Neosartorya fischeri
51% to CYP623B2, 46% to 623B4
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP623E1 Aspergillus terreus NIH2624
AAJN01000124.1
93% to CYP623E1 = ortholog
See fungal pages for seq
CYP624A1P Fusarium graminearum
AACM01000117.1 Gibberella zeae PH-1 revised
See fungal pages for seq
CYP624A2 Fusarium oxysporum
80% to CYP624A1P Fusarium graminearum
See fungal pages for seq
CYP624B1 Grosmannia clavigera
CYP625A1 Fusarium graminearum
FG10991.1 AACM01000457 FGcontig1.457_scaffold8
See fungal pages for seq
CYP626A1 Fusarium graminearum
FG11465.1 AACM01000467 FGcontig1.467_scaffold9
See fungal pages for seq
CYP626A2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_58000026
Necha1/scaffold_58:57207-58707
59% to 626A1 Fusarium graminearum probable ortholog
See fungal pages for seq
CYP626A3 Fusarium oxysporum
67% to CYP626A1 Fusarium graminearum
See fungal pages for seq
CYP626A3 Fusarium verticillioides
90% to CYP626A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP627A1 Fusarium graminearum
FG07804.1 AACM01000320 FGcontig1.320_scaffold4
See fungal pages for seq
CYP627A2 Fusarium sporotrichioides
GenEMBL AY226098
Brown,D.W., Proctor,R.H., Dyer,R.B. and Plattner,R.D.
Characterization of a fusarium 2-gene cluster involved in
trichothecene C-8 modification
J. Agric. Food Chem. 51 (27), 7936-7944 (2003)
gene="P450B"
94% to CYP627A1
MWSSKPLHDNLAQVASSFPPEVSETLSNLTLTQGFLAFLVLFII
VPRVFELLRNIFSPVSRIPGPLINKLSPWPLEIATFKGKSHLFARALHQKYGPIVVLA
PNMISVGDANEIKRIIQNEDWVKSEAIYGNFRQDPHRPTLLAFTEKKAYSRRKRMLSS
MFGIRYIRSLEPLMKSCVDAGVAHLDKLCENSNNSTVINLQHFIHGLAIDTIGATTFG
GSFNVVENGSHPLPSRLKAGMKISAVMQLISWIKYIPFLPKRDPYIEEFTFKIVDKRR
KESGDVKHQDLLQHLVDVSDDSPGSEFRTSDVQDESVILLAAGSETTANAELFTIMQL
LKHPHVMKKLVEEVDKWYPPSEPDRETECAYSQAGMTYLQACIDETMRLIPGQATGSP
RDASKQETVLGYGIPKGTTVFPNTQEAHLDSDNWKNPDKFVPERWLDIYSQNQTSSVP
YWPFSAGSRVCVGKHFAFQEMHISLTTLLRKFSFEYVPGQDETTVFRIAQQLQANSYD
VKVKRRSV
CYP627A3 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.8.77.1
Necha1/scaffold_8:382363-383945
69% to 627A1 Fusarium graminearum probable ortholog
See fungal pages for seq
CYP627A4 Fusarium verticillioides
83% to CYP627A2 Fusarium sporotrichioides
not found in the F. oxysporum genome
See fungal pages for seq
CYP627A5 Metarhizium anisopliae var. anisopliae Ma23
CYP628A1 Fusarium graminearum
FG03086.1 AACM01000147 FGcontig1.147_scaffold2
See fungal pages for seq
CYP628A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.35.73.1
Necha1/scaffold_35:40906-42850
53% to 628A1 Fusarium graminearum probable ortholog
See fungal pages for seq
CYP628A3P Fusarium oxysporum
51% to 628A2, 48% to 628M1, pseudogene
See fungal pages for seq
CYP628A3P Fusarium verticillioides
83% to CYP628A3P Fusarium oxysporum
See fungal pages for seq
CYP628A4 Fusarium oxysporum
62% to CYP628A1
See fungal pages for seq
CYP628A4 Fusarium verticillioides
86% to CYP628A4 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP628B1 Gibberella moniliformis 7600 = Fusarium verticillioides
GenEMBL AAIM01002625.1
47% to 628A1
same contig as CYP5055A2 about 16kb apart
7029 MITLSNIQLESLSALCCVALCGVATHLAIFRIGEWDVAVHRIIASFSLIYASIFGLLAYYGDFERQ
6851 SLLNAWYIASELLAAFIAGLYGSMVLYRFFFHPLRQFPGPTFAPLSALCAISMSMKKFHM 6672
6671 FLEVQKLHKTYGDFIRL (1) 6618
6558 GPSEISVASPSAVATIYQNSSPCKKGPWYNVFVPTISLHATRDRQEHTLRRKVWDRGL SAK (1) 6376
AMRDYEPRIEKYTGLLMNQLQQRCGRPVDITDWCGFYGF 6205
6204 DVMGDLAFGKSFNMLNDGVKHYYMELTQMSTLWGSPIGRASWLYLLVKDIPILNRQIVQFLK 6019
6018 WLRKHVDQRTK (0) 5986
5933 NEPHLPDLFSWLLGAYKEQSVHTKQDDLNLLGDAHLIVVAGS (2)
5756 DTTSTTMTCALFELARHPQVYQKLQNEVDEFMKQGDSPHSHSALAKLKYLQAIIDETMRL 5577
5576 YPAIPSGLQRITPPQGLQIDGTFIPGNTIIQTPTYTLNR (1)
DERCFVRPNDFIPERWTTQPDLVRDASAFAPFSI (1)
GRYSCAGKQLGLLE 5217
5216 VRHVLAQIASKFNIRLAPNQTVEAFQEGLADGFTLLCPKLEMVFEARVS* 5067
CYP628B1 Fusarium oxysporum (temp CYP628B2)
80% to CYP628B1
See fungal pages for seq
CYP628B2 Grosmannia clavigera
CYP628C1 Aspergillus oryzae
GenEMBL AP007162 also BAE61392.1
47% to 628A1, 45% to 628B1
MDTLWVLAFSSGVATHLLLYRSGEWDIKAPSIVKIYTLLGATLVYLERADLL
DGFPVSTRPKWGIAVILYHIFGVYAS
MLFYRAFWHRLCGFPGPFLARLSNFYVTSLSAKRLHLYEEVQKLHQQYGDYVRLGPTELS
IADPQAVKALYSGQAKVTKGPWYTVLEPRVSLQMSRDKKEHARRRKVWDQGFSSK (1) 891591
891531 ALRDYEPRVSHYARQLLEAVR
KNVGKPMDMAKW
FNYYSFDVMGDLSFGKSFNMLAGGQDTYFSTQLHADMKSIGLFSHLTWLFPFFKRIPILNKDYLKFWDWV
GGRVEERIK (0)
891143 NEPDRPDVFSWILDAFQNGPKTKQDHLDLHGDAYLIIVAGS (2) 891021
890959 DTTAATLTNLFFHLAADHTWQAKLQEELDALPDLTQEKVTNVKLLDALINETLRLH
PAVPSGTQRLTPPEGLQIGDKYIPGDVMVCIPTHTLFRDERAFVRPDEFLPQRWMTQPELVKDASVFIPF
NAGPYSCVGKQLALMELRRVTAEILTRYDVEFAQGQTTEDFLDGKRDTFTLVTAPLKLVFRER
CYP628C1 Aspergillus flavus
98% to CYP628C1 Aspergillus oryzae
See fungal pages for seq
CYP628D1 Aspergillus niger
JGI gene model gw1.4.1072.1|Aspni1
36% to CYP628B1, 38% to gw1.13.785.1s, 39% to CYP628C1
C-term is short
See fungal pages for seq
CYP628E1 Histoplasma capsulatum G217B
ABBT01000077.1 Ajellomyces capsulatus G217B
43% to CYP628D1
C-term seemed too long so removed a possible intron
See fungal pages for seq
CYP628F1 Fusarium oxysporum
51% to CYP628C1 Aspergillus oryzae
See fungal pages for seq
CYP628F1 Fusarium verticillioides
91% to CYP628F1 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP628G1 Fusarium oxysporum
no gene model
66% to CYP628G1, 47% to CYP628F1
upstream = NmrA family transcriptional regulator
See fungal pages for seq
CYP628G1 Fusarium verticillioides (temp CYP628G2)
66% to CYP628G1, 51% to CYP628A3P Fusarium oxysporum
See fungal pages for seq
CYP628H1 Aspergillus terreus
46% to CYP628A2
See fungal pages for seq
CYP628J1 Metarhizium anisopliae var. acridum Ma102
CYP628J1 Metarhizium anisopliae var. anisopliae Ma23
CYP628K1 Grosmannia clavigera
CYP629A1 Fusarium graminearum
FG11424.1 AACM01000467 FGcontig1.467_scaffold9
AACM02000392.1 Gibberella zeae
See fungal pages for seq
CYP629A2 Histoplasma capsulatum
ABBT01000202.1 Ajellomyces capsulatus G217B
58% to CYP629A1
See fungal pages for seq
CYP629B1 Fusarium oxysporum
45% to CYP629A1 Fusarium graminearum
supercontig_36 275364-279696 region
See fungal pages for seq
CYP629C1 Metarhizium anisopliae var. anisopliae Ma23
CYP630A1 Fusarium graminearum
FG00012.1 AACM01000001 FGcontig1.1_scaffold1
See fungal pages for seq
CYP630A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.26.42.1
Necha1/scaffold_26:302810-304387
59% to 630A1 Fusarium graminearum probable ortholog
genome annotation in progress
This gene is six genes from a PKS gene
It is probably part of a toxin biosynthesis gene cluser
hydroxylating the PKS product.
See fungal pages for seq
CYP630A3 Aspergillus oryzae
GenEMBL AP007164.1a, BAE62007.1
CDS complement(738572..740134) no introns
First P450 of six on this accession
62% to 630A2
MPGIYVLAAAGALALGVGYVVILPIIHYFYDPKGFRKYPNFAPLAGITDLPYCYLSSCGYRSKDLYEAHK
NAPILRIGPNNLSFGRIGAVKDIYGHNTPCIKDIKYAMTWGSHTHLFDVIDKADHAAKRKRMSSAFAIKN
SERWEHKVANVTGRLVKALDAHCTLPLLPGQTEPQAADVTLDYNKWINLFTIEAINLIALSSTLGLLEKG
SDEVTAQRKDGTTYPARYRKSQDSTAHAQSLFVWDYKYFHWLSRLSKLVPKYRQMWKDGEPWGDVIYHQA
VTRLQRYQSGEKLDDFFSSLMEDKAGHPNNLEWGEIVAEVGAIINAGADTTAIALTQVLDILIRHPKYLQ
RLREEVDSTLDADEVVAPYDKVKNLPFLRACLDEALRLIPPTSAGLPRRTPPEGAQILNEWIPGDTSVSM
TSYSAHRDPEIFPVPEEYNPDRWMDLDNRKRMEPYFVPFSTGARGCLGRNITYLEQTVVLATLVHRYDFA
VPANWKLGRFEAFNLIMGEMPMKIWRREKA
CYP630A3 Aspergillus flavus
98% to CYP630A3 Aspergillus oryzae
See fungal pages for seq
CYP630A4 Fusarium oxysporum
85% to CYP630A1
Supercontig_19 936278-937336 (-) strand
Supercontig 19: 932834-933337 (-) strand
C-terminal half 3000 bp away with no good boundary, possible pseudogene
See fungal pages for seq
CYP630A4 Fusarium verticillioides
96% to CYP630A4 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP630B1 Fusarium graminearum
AACM01000338.1
See fungal pages for seq
CYP630B2 Aspergillus nidulans
AN5837.1
60% to 630B1 53 clan
revised 7/19/07
MITLTYAAITGLLVLVYFVIWPVFEYFRDPKGLRRYPNMSIFSGISAIP
FMLMASRKFRSKELQELHKKHPVLRTGPNSLSYGDVRAIKDIYGHNTRCG
KDPSYIVSAGSHYHLADVIDRADHSRKRKVLSSAYALKNLETWEHKVSDK
IARLVKHFDSVCTAPLPAGQEEPDPADLTVDFRAWTNFFSLDAIVDIGLS
EKLGFLDQGHDMCTAERKDGTTYRASLRDALYPNARKQSLLLWNYDWYPI
INRWVNIIPYFAKMQKSSDTWEDIVWHHAMQRRRRYEAGEKLEDFFSALM
EDKAGHPLGLEWGEVCAEINIMMNAGSVTTAIAITNVMYQLLRNPQCLAT
LREEIDSVYDSEDEVVASYDKVKHLPYLRACLDESLRIFPPTSHGLPRET
PPEGMEILGQWVPGKTSVSMSAYVAHRDETVFPEAYLYKPERWLGEEGKA
LQPYFVAFSAGARSCIGRNISYLEQTVILATLVRR
YEFALPSKDWELQREETMNLILGGMPVKVWRRQLDGDA
CYP630B3P Aspergillus nidulans
AN2191.1 55% to 630B1pseudogene
See fungal pages for seq
CYP630B4 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.1.300.1
Necha1/scaffold_1:1594762-1596339
84% to CYP630B1 no introns probable ortholog
See fungal pages for seq
CYP630B5 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.52.31.1
Necha1/scaffold_52:135577-137148
65% to CYP630B1
See fungal pages for seq
CYP630B6 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.20.309.1
Necha1/scaffold_20:354486-356086
60% to CYP630B1
See fungal pages for seq
CYP630B7 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_50000029
Necha1/scaffold_50:99287-100920
58% to CYP630B1
See fungal pages for seq
CYP630B8P Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_30000003
Necha1/scaffold_30:23907-24329
55% to CYP630B7
See fungal pages for seq
CYP630B9 Aspergillus fumigatus
GenEMBL XP_755127.1
61% to CYP630B1 FG
MWSLFTIAPYACILGLLLFVYFIAYPFVEYIRDPKGLRRYPNFHPFSGMSAIPFMVLASRGFRSMELLNL
HRKHPVLRTGPNTLSYGDVRAIKDIYGHNTKCIKDPSYIVTAGTHYHLADVVDKPDHARKRKVLSSAYAL
KNLETWEYKVSDKLERLIAHFDRVCTKPPSAAVAEGKAAPDPADLTVDFRAWTNFFTLDAIADIGLSEKL
GFLDSGSDVCTAERKDGTTYEVHLREALYPTARKQSLILWNYEWYPVLNKLVNIIPFFRRMQRSSDNWEN
IVWRRASQRLRRYEAGEKLDDFFQALMEDKNGHPNNLEWGEIVAEVNIMMNAGSVTTAIAIANVMYQLLK
NPRCLAKLREEVDAVLDEEDIIAPYDKVKHLPYLRACLDESLRIFPPTSHGLPRQTPPEGMEILGQWVPG
NTSVSISALVAHRDESVFPQADQYIPERWLGEEGKALQPYFVAFSAGARSCIGRNISYLEQTKAIATLVH
RYEFALPHPGWELKRLETMNLILGDMPVKVWRRQT
CYP630B9 Neosartorya fischeri
97% to CYP630B9 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP630B10 Aspergillus fumigatus Af293
GenEMBL XP_748668.1 also EAL86630.1
46% to 630B2 with errors
closer to 54% if gaps removed, needs revision
MLGMMLLLGLLARLFFRFVIWAIFVYLRDPKGLRKYPLMHPLSGISDIPFMLESMRGFRSATLLQLHYGQ
GHPVIRLGPNALSFAGGQAIPAIYGHNTPATKDRQYLNAAGSHFHLADVVDKKEHARKRKVLASAFAAKH
LEDWEYKVADKVQRLMQRFDQHLAQMPDDPLDYRSWTNLFTIDSLCDTLIVAPTVSFRDCLYATFHIVGD
LVWSYEWYHVVSWLLQRVSAHDIFAALMEDPAGNPQDLEWGEVLAEISLAISGSSSTSNSIASTMQLLIE
HPEKMRKLQEEVDSVMATQLEDSPDGDTPTVASYDQIKSLPYLRAVIDESLRLYPPISHGLPRETPKEGM
MIMDQWVPGNTTVSVSAYVAHRDPAVFDQPESFVPERWLGEQGRALQTRFIAFSAGARGCIGRPISYLQA
SILLANLVHQYDFEMWDPKWKPSRRETMNLIMGPMPPGGFSGEGG
CYP630B11 Aspergillus oryzae
GenEMBL BAE66547.1
59% to 630B2
MYSLLLIVTLHFLLIYYIIIPIINYFRDPKGLRKYPNLTFVSGISDLPLIYYSHKGIRSRVLFEAHKKHP
VLRIGPNKLSYADPVAIKDIYGHGTKCTKDVFYSALSGSHYHLADVVDKEDHARKRKVLSNAYAIKNLEG
WEYKVADMTQRIIKAFDERCTSPLPKGRNPDPQDLTIDYRMWTNLYTIAAIANIGLSEDIRFLDQGNDII
SSEAKDGTVKKVHFRDCLYANASATSTLVWAYDWYEALVRVSKLVSSTYRQKWKLAEDWDGIVNNRATTR
WKRYEKGEKLDDFFSALMEDKAGAPNNLEWGEIVAEVSIMMNAGSDTTGISLNNVMLLLLKNPHCLEKLR
EEIDGVLEDDEVIAPYDKVKHLPYLRACLDENMRMYPPVSFHVPRRTPQEGTMIRGEFVAGNTSVGISAY
VVHRNEDIFPDPDTYKPERWLGDKGRDLQPYFVAFSAGARGCIGRNISYLEQTVLLASLVHRFEFALPSP
SWEPVRHETTNFNSGPMPLKVWRRASRVYEDN
CYP630B11 Aspergillus flavus
100% to CYP630B11 Aspergillus oryzae
See fungal pages for seq
CYP630B12 Aspergillus oryzae
GenEMBL BAE65338.1, AP007171.1
57% to 630B11, 75% TO 630B13, 77% to 630B2
14 P450 genes and 2 pseudogenes on this contig
MWSALSIAPYALVLGLFSLLYFVVFPWVEYIRDPKGLRKYPNMNPFSGMSAVPFMLLASRGFRSKELQEL
HRTKPVIRTGPNMLSYGDVRAIKDIYGHNTKCIKDPSYIVTAGTHYHLADVVDKPDHARKRKVLSSAYAL
KNLETWEHKVSDKVEKVVAHFDKVCTAPPSAAVAAGKMAPDPKDLTVDFRAWTNFFTLDAIADIGLSEKL
GFLDSGSDVCIAERKDGSTYEVNLREALYPTARKQSLILWNYEWYPVLNKMVNIIPFFNRMQNSSDNWDN
IVWRRSMNRLRRYEAGEKLEDFFQAMMEDKNGRANNLEWGEIVAEMNIMMNAGSVTTAIAIANVMYQLLR
NPQSLKKLQEEIDAVLDADEIVAPYDKVKHLPYLRACLDESLRIFPPTSHGLPRETPPEGMEILGEWVPG
NTSVSMSAYVAHRDESVFPKADQYIPERWLGEEGKALQPYLIAFSAGARSCIGRNISYLEQTKILATLVH
RYDFALPYPGWELKRLETMNLILGDMPVKVWRRNVQEA
CYP630B12 Aspergillus flavus
100% to CYP630B12 Aspergillus oryzae
See fungal pages for seq
CYP630B13 Aspergillus oryzae
BAE63103.1
75% TO 630B12, 62% to 630B7
MLSLVLVAPYAAVGGLCTLLYFFVFPFIEYIRDPKGLRKYPNLHPISGMSVLPFMFMASRGARSQELSEL
HKKSPVIRTGPNTLSYGDVRAIKDIYGHNTKASKDPSYIVSAGTHYHLADVVDRADHARKRKVLSSAYAL
KNLETWEYKVSDKIERLVKHLDKCCTAAPVSGGRAFVPSSEDLTVDIRAWINFFTLDAMADIGLSEKLGF
LDKGNDICVAERKDGSTFECGLRDALYPLAIKQCMVLWNYEWFPIINKLVDVFPYFRNLQKKGDAWEHII
WRRSSERLRRYEAGEKLNDFFQALMEDKNGRPNNLEFGEIAAEVNIMMNAGTVTTAIAITNVLYQLIRHP
EAMAKLREEIDGVLGPDEIVASYDTVKHLPYLRACLDESLRILPPTPHGLPRQTPPEGMEILGEWVPGNT
LVSISAYVAHHDESVFPQPHKFIPERFLGEAGKELGPYFITFSAGARSCIGRNISYLEQTKALATLVHRY
DFALPYPDWEPKRFESMNHILGEMPIKIWRRSFDG
CYP630B13 Aspergillus flavus
99% to CYP630B13 Aspergillus oryzae
See fungal pages for seq
CYP630B14 Aspergillus niger
fgenesh1_pm.C_scaffold_20000049|Aspni1
77% to CYP630B11
See fungal pages for seq
CYP630B15 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_9000258|Aspni1
88% to CYP630B12
See fungal pages for seq
CYP630B16 Fusarium oxysporum
90% to CYP630B4 Nectria haematococca
See fungal pages for seq
CYP630B17 Fusarium oxysporum
81% to CYP630B7 Nectria haematococca
See fungal pages for seq
CYP630B17 Fusarium verticillioides
95% to CYP630B17 Fusarium oxysporum
See fungal pages for seq
CYP630B18 Grosmannia clavigera
CYP630C1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.19.274.1
Necha1/scaffold_19:134969-136557
46% to CYP630B1
See fungal pages for seq
CYP630D1 Aspergillus oryzae
GenEMBL BAE60571.1
43% to 630B2, 48% to 630C1, 44% to 630B5, 43% to 630A3
MALEKLFIVVFLCFALRPLLLYFYDSKKLRKYPNQNFLSGVTNLASIRERQRKFRTRELYLQHQKHPIIR
VAPNMLSFRDVKAIKDIYGFGSPCQKHEIYKLQNSEGHMNILNVIDREDHNRKRRMLSHAFSTKNLESWE
FKITDKVEKLVAQFDRRAHPPAWKNEPSQQNNTTVDVRYWLNLFTVDAIADIALSERLGMLESGSDVVKV
GGPGEEDSAHRFIEDMHEAARVKSKIIGTLDWYYVLKQVSSFLSSRCRSQWDCGGNVGQIVEHLAGKRLR
RHEDGENIDDFLSCLINDKAGKSRNLDIGELKAETSILLDAGSETTAIALTHLLYYLIKNPDCFVKLRKE
VSGAIAGDKVAPYAKVKSLPYLKACIEESLRLSPPLPRGLERVTPAAGAYIMGEFIPGNVGVSVPAYVAH
RDPDLFPEPEAFLPERWFNNENIGKMRDAFIPFSAGGRACIGRNITMIEQQILIATLVHRYDFSLASPDW
TLQNEEAFNLWPVELPVKIWERDLEA
CYP630D1 Aspergillus flavus
98% to CYP630D1 Aspergillus oryzae
See fungal pages for seq
CYP630D2P Aspergillus oryzae
GenEMBL BAE62696.1, AP007166.1
Downstream from CYP551A2 (BAE62699.1) (145541-147583)
note: two other genes between these
This gene is a pseudogene missing the top half
39% TO 630D1, 37% to 630B1
136724 VQTTEYYRSLQEHGKDGCFDNTIFDSVLRSFAEIQEGSNLTKVQTEKLVDEAFAI
MFAGSDTTAFSLTITLVYLCKYPEKIVKLRREVQCLRDFKVQDIQLATISQMPYLDAVIREANRLSSPLS
TVLPREVPSTGCVISGHFLPKGTVVGFHLDDINRNPKFFPEPNDFIPERWSGEEGKKLQRWFVPFSKGSR
RCIGMDFAFVEMKLAVAAIISRFEIWLDNPNVTLNSREMFVKIPEDDLRIRLRAITV
135844
CYP630D2P Aspergillus flavus NRRL3357
GenEMBL AAIH01000541.1 pseudogene
same gene as Aspergillus oryzae BAE62696.1,
97% identical
runs off the end
418 VQTTEYSRSLQEHGKDGCFDSTIFDSVLRSFAEIQEGSNLKVQTENLVDEAFAI
MFAGSDTTALSLTITLVYLCKYPEKMVKLRREVQCLRDFKVQDIQLATISQMPYL (0)
DAVIREANRLSSPLSTVLPREVPSTGCVISGHFLPKG (0)
TVVGFHLDDINRNPKFFPEPNDFIPERWSGEEGKKLQRWFVPFSKGSRRCIGMDFAF
VEMKLAVAAIISRFEIWLDNPNVTLNSREMFVKIPEDDLRIRLRAITV* 1301
CYP630D3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_2000776|Aspni1
54% to CYP630D1
See fungal pages for seq
CYP630D4 Neosartorya fischeri
57% to CYP630D1
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP630E1 Uncinocarpus reesii
51% to CYP630B14 A. niger, added back part of heme region
See fungal pages for seq
CYP631A1 Fusarium graminearum
FG10329.1 AACM01000425 FGcontig1.425_scaffold7
See fungal pages for seq
CYP631B1 Aspergillus nidulans
AN3225.1
38% to 631A1 53 clan
revised 7/19/07
MDHPHPSTFSL
GLSQILVCLALLYAAIHILSV
YRRLCHISGPFWARIS
NLPRVWWVNTSRAHEIHQQLHEKYGDVVRFGPNMVSLRNPTWIPTVYPTR
MGVKKSDFYRTLAPYTPSGALPAVFSSRDEEVHRGLRGPIASLYSMSKVL
PLEVFVDRTIDVLVRQLDGRFAGAGETFDLASWLQFFAFDVMGTLTFSKR
YGFLEKGMDVHGMLDTIWRFLKGAAPFTQIPWVDEIWNKNVLATKLKGAT
GVSILGIVGKFVSQRQEESKAGKIDGTADRDMLSLFMEIQKNNQLPPWYV
TAWTFSNITAGSDSAAVVMRTVFYNLLSHPSTLQKLRSELLSAGPLTQPY
PSWKDVCNLPYLDACILEALRLHPPFCLPFERIVPQGGMVLGDTYFPEGT
VVGMSPWVVNRHKPTFGEDSDVWNPERWMVSKELKSKREAAVLTFGAGRR
VCLGRHIAILELKKIVPALVLRYDFELIDPERFTTENFWFFRQRGMDVRV
KKRMQAEAGI*
CYP631B2 Aspergillus oryzae
GenEMBL BAE65443.1
52% to 631B1, 43% to 631A1
MRRALHVAQVRGLATGQCRPRVQASRSIIRPREEPFRSSVMLILLGLLCLYTGLYVARTYWRLRHFPGPL
VARFTDLGRLWWVKTSRSHHHHMGLHSRYGQYVRLGPNMISISDPDAIPLVYPIRPGVPKSDFYRSMMPY
TRKGRSLPLVFNTRDEDLHKRLKTPIAHLYSLSNILTFEAFVDQVLEILFRQFEERFVPDQAPFNLGNWL
QYFAFDVMGTMSFSRRYGFLEKGRDDTGLLSAIWAFMKAAAPVTQMPWVDLVWNKNPFIALFRATPAQPI
LNVVLSRINDRRNELYSTTSTPEKVNERDFLSRFMHIQSNSDTIPPWAVTAWSFSNVIAGSDTTAVAMKT
LWY
NLLLHPATMHRLRKELVQAQQQSKLSHPFPAWNEISGLPYLNACVNEALRIHPPFCLPFERIVPAEGMTIGD
HFFPGGTVIGMNPWVINRHRPTFGEDADAWRPERWLEDPARTRQMEN
TLLSFGAGRRVCLGKNIALLELKKLTSALVLHYE
LEIVNPEKFQSQNFFFFKQEGLYAAVKRRSAGSPELYPDDAVPH
CYP631B2 Aspergillus flavus
100% to CYP631B2 Aspergillus oryzae
See fungal pages for seq
CYP631B3P Aspergillus oryzae
GenEMBL BAE56559.1, AP007152.1
52% TO 631B2, 56% to 631B1
pseudogene
24632 NLLTHPATLQALSSELITANLTLPYPKWNEVCDLPYLDACIQEAVRLHPPF
ALVLGRVVPAGGVTVLN
HYLPEGTLVGGNPYVVNRHAETFGPDVEEWRPERWLEGEGRKRLEQS (0) 24285
FDAGRRVCLGKYIGILELKRLVPFLVLKYD (0)
MKIIDPERFSVENGFFFKQRGFYCNITRRKEGSDRDKADPK*
CYP631B3P Aspergillus flavus
100% to CYP631B3P Aspergillus oryzae
See fungal pages for seq
CYP631B4 Talaromyces stipitatus
GenEMBL ABAS01000029.1, XP_002339966.1
61% to 631B1, 44% to CYP5077A1 note this might be misnamed
MDSMNIFPGYRQADSIVFIAVGSILGLSL
285172 LHLLRTYWRLRYIPGPFLARFTNLQRVYWVKTTRAHEIHQQMHEKYGNVVRFGPNMVSLG 284993
284992 DPALIPSLYPIRPGFPK (0)
SDFYRSLMPYTRKGGSLPAV 284813
284812 FNTRDENLHKVIKTPIAPLFSLSNILPLEVFVNRVLEVLFQQLDTRFVSSGDTFDLADWL 284633
284632 QYFAFDVMGTLTFSKR 284585
YGFLEHGRDVNNMLLTIWTYMSNCAP (0)
MTQIPWFDVVWNKNAFITLFRRASGLSILGHVGELIA
DRRQRRNTPSAVSDEKASDRDMLSRFFELQEKDSKIPRW (2)
AVTAWAFSNVIAGSDSTAVTMRTTWFGLLSHPETLKTL
RKELLDQDSKLEGGITRPFPAWKDICNLAYLDACVNEAVRLHPPFCLPFERVVPSGGLTIGGTYFPAGTVVGM
SPWVINRHRPTFGHDAESWRPERWMVPEEHRRKLEQSVLT (0)
FGAGRRVCLGKHIAMLEIKKLTAALALNYE (0)
FDLLDPKRFKVENGWFFRQYGMDVKARKATVWEEDKKQ*
CYP631B5 Penicillium brevicompactum
HQ731031.1
Bjarne Gram Hansen
Submitted to nomenclature committee Jan. 18, 2011
56% to CYP631B1
myciphenolic acid biosynthesis gene cluster
fusion to another sequence at C-term (mpaD + mpaE).
CYP631C1 Metarhizium anisopliae var. anisopliae Ma23
CYP631C1 Metarhizium anisopliae var. acridum Mac04556
CYP631C2 Phaeosphaeria nodorum SN15
XP_001797041.1 hypothetical protein SNOG_06679
AAGI01000142.1 Phaeosphaeria nodorum SN15 cont1.142 39344-38051
gc boundary at LTYE
56% to CYP631C1 Metarhizium anisopliae var. acridum Mac04556
39717 MDRNVLVLDFGMAGGVAVVAVVLIVAFVTAHTARTWWRLRHIPGP 39583
39582 FLASITDLYRMNWVKTTRAHLKLQQCHERYGKLVRIGPNTVSFSDPVAIPEVYPMRAGMPK (0) 39400
39338 SDFYVTLRPYTSGQALHAVFNTTEESILKQIKPPIAPLFNISSAATLEPLVDEVLECIRGRFDERFVG
TGQIFDMGQWLQFFAFDVMGTMTFSKRYGFLDKGRDVGGMLGAIVDFMRTAAP (0) 38976
38923 MTQSPLLDKLLRKNVVVDTLRQYIRPTASLTILSFVGQAIKEKKEKMESKTSKSE
GQIDFLTRYIELQKHNPSIPPWAPTAWTFSNVIAGSDSVGTCMRTMLYHLLAYPNTFDRLYKELLAAKTS
RPFPSYSEVRELPYLEACVQEAIRVHPPFALPLERVVPDGGMTVLGYFLPGGTVIGGSPYVVNRDTSMFG
EDAEFWRPERWLGGDAAHKRSLEASMLT (0) 38255
38199 FGAGRRICLGRHVGILEIKKLIAFLVLTYE (0) 38110
38061 IRLVDRERFEVENLWFFFQRGFFAQIQKRNVE* 37963
CYP632A1 Fusarium graminearum
FG03264.1 AACM01000150 FGcontig1.150_scaffold2
See fungal pages for seq
CYP632A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.80.13.1
Necha1/scaffold_80:8615-10329
70% to CYP632A1
See fungal pages for seq
CYP632B1 Mycosphaerella graminicola
JGI gene model e_gw1.6.392.1|Mycgr3
39% to 632A1, 40% 632A2, next best hit is 30%
to 5078A4 yedllow from JGI model
See fungal pages for seq
CYP633A1 Fusarium graminearum
FG03796.1 AACM01000164 FGcontig1.164_scaffold2
See fungal pages for seq
CYP633A2 Nectria haematococca (Fusarium solani group)
fgenesh1_pg.scaffold_48000021
Necha1/scaffold_48:55055-56793
55% to CYP633A1
See fungal pages for seq
CYP633B1 Fusarium graminearum
FG08207.1 AACM01000329 FGcontig1.329_scaffold5
See fungal pages for seq
CYP633C1 Metarhizium anisopliae var. anisopliae Ma23
CYP634A1 Fusarium graminearum
FG02872.1 AACM01000142 FGcontig1.142_scaffold2
See fungal pages for seq
CYP634A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.26.228.1
Necha1/scaffold_26:232434-234178
64% to CYP634A1 probable ortholog
See fungal pages for seq
CYP634A3P Fusarium oxysporum
75% to 634A1, pseudogene fragment, no upstream P450 seq.
See fungal pages for seq
CYP634A5 Fusarium oxysporum
75% to CYP634A1
See fungal pages for seq
CYP634A5 Fusarium verticillioides
93% to CYP634A5 Fusarium oxysporum
See fungal pages for seq
CYP635A1 Fusarium graminearum
AACM01000329 FGcontig1.329_scaffold5
See fungal pages for seq
CYP635A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.25.117.1
52% to CYP635A1 probable ortholog
See fungal pages for seq
CYP635B1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_35000113
Necha1/scaffold_35:263720-265404
46% to CYP635A1 probable ortholog
See fungal pages for seq
CYP636A1 Fusarium graminearum
AACM01000111 FGcontig1.111_scaffold1
See fungal pages for seq
CYP636A2 Fusarium oxysporum
86% to 636A1
See fungal pages for seq
CYP636A2 Fusarium verticillioides
92% to CYP636A2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP637A1 Fusarium graminearum
AACM01000159 FGcontig1.159_scaffold2
See fungal pages for seq
CYP637A2 Fusarium oxysporum
78% to CYP637A1
See fungal pages for seq
CYP637A2 Fusarium verticillioides
97% to CYP637A2 Fusarium oxysporum = ortholog, C-term is extended
See fungal pages for seq
CYP637B1 Metarhizium anisopliae var. acridum Ma102
CYP638A1 Fusarium graminearum
AACM01000111 FGcontig1.111_scaffold1
See fungal pages for seq
CYP638A2 Fusarium oxysporum
77% to CYP638A1, one frameshift
See fungal pages for seq
CYP638A2 Fusarium verticillioides
94% to CYP638A2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP638B1 Histoplasma capsulatum G217B
ABBT01000036.1 Ajellomyces capsulatus G217B
38% to CYP638A1, ony 25% to next best hit
See fungal pages for seq
CYP637C1 Grosmannia clavigera
CYP639A1 Fusarium graminearum
AACM01000166 FGcontig1.166_scaffold2
See fungal pages for seq
CYP639A2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_25000008
Necha1/scaffold_25:22167-24012
64% to CYP639A1 probable ortholog
See fungal pages for seq
CYP639A3 Fusarium oxysporum
69% to CYP639A1 Fusarium graminearum
See fungal pages for seq
CYP639A3 Fusarium verticillioides
90% to CYP639A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP640A1 Fusarium graminearum
AACM01000459 FGcontig1.459_scaffold8
See fungal pages for seq
CYP640B1 Fusarium oxysporum
47% to CYP640A1
See fungal pages for seq
CYP640B1P Fusarium verticillioides
68% to CYP640B1 Fusarium oxysporum
no gene model, supercontig 19 373448 - 373945 region
See fungal pages for seq
CYP641A1 Fusarium graminearum
AACM01000454 FGcontig1.454_scaffold8
See fungal pages for seq
CYP641A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.11.569.1
Necha1/scaffold_11:397275-399029
64% to CYP641A1 probable ortholog
See fungal pages for seq
CYP641A3 Fusarium oxysporum
84% to CYP641A1 Fusarium graminearum
See fungal pages for seq
CYP641A3 Fusarium verticillioides
93% to CYP641A3 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP642A1 Fusarium graminearum
AACM01000081 FGcontig1.81_scaffold1
See fungal pages for seq
CYP642A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.47.68.1
Necha1/scaffold_47:131858-133483
56% to CYP642A1 probable ortholog
See fungal pages for seq
CYP642A3 Fusarium oxysporum
85% to CYP642A1
See fungal pages for seq
CYP642A3 Fusarium verticillioides
94% to CYP642A3 Fusarium oxysporum ortholog
See fungal pages for seq
CYP642A4 confidential basidiomycete
CYP643A1 Fusarium graminearum
AACM01000117 FGcontig1.117_scaffold1
See fungal pages for seq
CYP643A2 Fusarium graminearum
AACM01000091 FGcontig1.91_scaffold1
See fungal pages for seq
CYP643A3P Fusarium oxysporum
71% to CYP643A1 Fusarium graminearum
See fungal pages for seq
CYP643A4 Fusarium oxysporum
67% to CYP643A2
See fungal pages for seq
CYP643B1 Fusarium graminearum
AACM01000196 FGcontig1.196_scaffold3
See fungal pages for seq
CYP643B2 Fusarium verticillioides
70% to CYP643B1, not found in the F. oxysporum genome
See fungal pages for seq
CYP643C1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_4000279|Aspni1
44% to CYP643B1
See fungal pages for seq
CYP643C2 Aspergillus oryzae
Supercontig 6: 919868-921806 (+) strand
See fungal pages for seq
CYP643C2 Aspergillus flavus
60% to CYP643C1 Aspergillus niger
99% to CYP6343C2 Aspergillus oryzae
See fungal pages for seq
CYP643D1 Neosartorya fischeri
43% to CYP643C1
Note: this seq has no ortholog in A. fumigatus
See fungal pages for seq
CYP643E1 Neosartorya fischeri
52% TO CYP643C1
NOTE: THIS SEQ DOES NOT HAVE AN ORTHOLOG IN A. FUMIGATUS
See fungal pages for seq
CYP644A1 Fusarium graminearum
AACM01000444 FGcontig1.444_scaffold7
See fungal pages for seq
CYP645A1 Fusarium graminearum
AACM01000005 FGcontig1.5_scaffold1
the second part after the heme signature resmbles a
phthalate 4,5-dioxygenase reductase subunit
See fungal pages for seq
CYP645A2 Fusarium oxysporum
60% to CYP645A1, this seq. has a C-term extension
the second part after the heme signature resmbles a
phthalate 4,5-dioxygenase reductase subunit
See fungal pages for seq
CYP645A2P Fusarium verticillioides
85% to CYP645A2 Fusarium oxysporum
no gene model, no introns
the second part after the heme signature resmbles a
phthalate 4,5-dioxygenase reductase subunit
See fungal pages for seq
CYP646A1 Aspergillus nidulans
AN2596.2 AACD01000043
Revised 7/18/07
this gene may have a frameshift & rather than an intron as shown below
based on comparison to other sequences
This may be a pseudogene
MLLELDVSLFSMAALVGTLVCIVVKLFETSPVPKDIPWV
LKKQNVLRRAAERFIGVNPISFIQEGYEK (0)
YSKNQQPFVMPSVNEGDEVVLPREHSNLVLFAKES
EYSFKAHISDFFQLKYTSWPLAFAEKYDFFVKLVSKDLTETLKSDAIAEA
LANEARACLSDIWGEDEDNWVEVPLYSAME
KSAA 261319 & 261317 RLINVLAIGPGNS
HDTSLLNAMTNCSNAIVFGANVIKAFPSFLHG (2)
IVGPIVGLVNRWQERVFHTRMKPLIEARIKTQREAVDKAALQENLKAQGSLLDMLINAGLRSKW
PVEVETMWLAYRIFMINFPGVHTSGISATSALLDILSFPSEEGLIDMLQAEIQNIAAS
SCGKWTAAELEQASLLDSAIKESLRFNGINALSPTRM (0)
VVAPEGTTLPNGLFLPYGTKI
GIPQYAVHRDSDLYPNPDQYNPYRFYTPGASPAQLRESSMTNTSESYVVFGHGRRQCP
GRWIFAHIFKLLIAEMLLKYEIKPFPTRPKIH (1)
RWGRFQLPPLTTKLTVRRRKDTA*
CYP646A2 Aspergillus fumigatus
GenEMBL AAHF01000014
join(572205..572288,572338..572670,572727..573086)
locus_tag="Afu8g00960" second P450 of 8 on this accession
revised 7/18/07
80% to 646A1 Aspergillus nidulans
MLLNISAFALSTTGVLCMLLCLVVKLFETSPVPKNIPWVLSKKGFFGRAAERFLGVNPIGFIQEGYQQ (0)
YSKNQQPFVMPSVNEGDEVILPKEHSNAVLFAKESEYSFKAHISDFFQLKYTSWPLAFAERYDFFVKL
VSKDLTETLKSKAVAESLAEEARSCLSEFWGEDTDNWVEVPLYSFME
KVAARMVNVMAIGPGSS
HDTTLLGAMTNCSNAIVFGANVIKAFPSFVHP (2)
IIGPIVGLVNRWQERVFHARMKPIIEAKIKEQKEADDPQSLQERLKANGSLLDLLIQAGLRSKW
PVERETMWLAYRIFMLNFPGVHTSGISATSALLDILSYPTEEGLMDMLQAEIEQIAAN
SDGSWSAADLERASLLESAIKESLRFNGINALSPTRK (0)
VVAPEGAFLPNGVFLPYGTKI
GIPQYAVHRDSDLYPNPNEYNPYRFYKENATPEERRQNLMTNTSDTYLVFGHGRRQCP
GRWLFAHIFKLLIAEMLLKYEIKPFAARPKIH (1)
RAGWGRFQLPPLSVKITVRRKKNPVAVCNQFST*
CYP646A2 Neosartorya fischeri NRRL 181
XM_001261718
92% to CYP646A2 = ortholog
See fungal pages for seq
CYP646A3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_3000278|Aspni1
66% to CYP646A2
See fungal pages for seq
CYP646A4 Aspergillus clavatus
82% to CYP646A2, 79% to CYP646A1
See fungal pages for seq
CYP647A1 Aspergillus nidulans
37% to 623B1 54 clan
See fungal pages for seq
CYP648A1 Aspergillus nidulans
poor match 54 clan
See fungal pages for seq
CYP649A1 Aspergillus nidulans
32% to 503A1 54 clan
See fungal pages for seq
CYP650A1 Aspergillus nidulans
AN9251.1
40% to 54 clan
revised 7/19/07
MIIFNISALGPPKPMLQFVGRELVETSRATMLRLPIDSAMHPFSTLPNHE
LGLYIMWMMSAVFVIFKLLAPAKCDIPTVNGRRRFEIGQYQARRRFSVDG
RGIILNGLQMARVFRVVSQKGPKIILGPEYANEVKSHPACNADVFIAKEF
HAHVSGFEVLRPQQVMKDAIRLRLTRSIGALMKPISAETALILESQWGNS
NCWHELDLNFTIA
SLVSRVSAVMFVGEELGRDQKWLSIVTNYSSDMFVADLDLCKWPEALR
PIATYFLPSCGKLRRHIREAALMLYPILSEGYSAHQNKQNFLDWLEEIAG
DRKYNPVLAQLSLAAAAIDTTSDLIIKTLTDICRFRDSQKLQEDLREEMV
RVLRADGWEKSAMYNLKLLDSVLKETQRVKPVVVFGMGRYVTEQITLHDG
TVISKGETINVVNTRIWDPAVYPNPLEWDPYRF
VRRRDSGDHAAHLVSPTPDHMGFGLGKHSCPGRFFAATKIKIILCHILLK
YDVKIPDEEISTVISSG
NFLFPDSTLRISVRRRQDNLTIWD*
CYP650B1 Aspergillus nidulans
40% to 68a1 54 clan
See fungal pages for seq
CYP651A1 Aspergillus nidulans
AN9253.1
34% to 68D1 54 clan
revised 7/19/07
MLQETISLTPLGQPLIAGFVVVSAVLYLLYNTQQWRPNNLPLLNDGGPFD
FLQVTAVNRFRRDARRLIKSGFDS
MRTDVGVELFASPEYADQFRNHPSLKVFPFTAKMHHGHLPGFELCRSQPV
EDRILIESVRTQLAQSLGKLIQPLASDIGEAISDRWPSESGWQEIVLGSV
VERTIAQGTSSVYCLDEAWPEFVVKMEMALGMASAALSAWPVMLRRIVAK
FLPECLELYRIMKSGRELMSRDMRRRTALQASTGEEPLNFFEWFKEASHG
EEYDELILNLRIAFASMHGLCDHLVKILLRLSEDPQLVSDLRKEVIQVYE
THGWSKTALYHLKLMDSAFKEVQRVDPILFVGRVAVADVTLKDGLIIQKG
QSIRISGHTMWDEDKYPDAAHFDPYRFYRLRQAPGQENTAQFTSPTSDHL
GFGYGGRACPGRFFAAAVLKISLCHVLMKYDIKPANGETGQHVWEFAAAI
NANMTAKVLVRRRQPEIQI*
CYP652A1 Aspergillus nidulans
37% to 68D1 54 clan
See fungal pages for seq
CYP653A1 Aspergillus nidulans
33% to 503A1 54 clan
See fungal pages for seq
CYP653A2 Aspergillus fumigatus Af293
GenEMBL XP_748033.1 also EAL85995.1
47% to 653A1 with errors, 56% to last 366 aa
removed intron seq
MHLASFSLLTSITLHHYCAHNTPITLHNIDQLLNGTSLAQRRILRLSSAKLSVMADQVLELPCWPFALLL
SSSLYFFHYPPGETSAEIPTVRFSRFLPGFINRLMFIFVAPYLIKYGYEKYRDQPYRILKADGDLLVLPP
KYLPEIRHLPPSKLSGVDAQFENILGKYTNVLIDSNLPVKTVHKGLTPAI
GRVLPRLLDELQFAFQVEVPDCDDRWVPVNLYDMILGLVTRATSRVIVGKNICRNSQWLETVTSYTVNL
GVTVILLRPFPNFMRPLVAKVLPSVKKLRTQLRFVQNELFIPMILARREAEINGPAYQKPDDFLQWMMDL
AEDDFDKDPANISQMLLIVMALAVVHTSSMLMTHAIYDLMIRPEYIEPLREEIRGTLKDGWDKVTQASFA
SQRRLDSFMRESQRFNPTGELSTHRMVMETMVLSDGLVLEKGTHICFPSKPMGMDDSIIEDALTFRGFRW
CEDPEARSTSLVSISPSNMHFGYGRQACPGRFFAANTNKAILGRLIADYEFKFEGDNNKRPRNLTLGEQI
MPNMHTKILLKKRAFV
CYP653A2 Neosartorya fischeri
95% to CYP653A2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP653A3 Aspergillus clavatus
76% to CYP653A2
See fungal pages for seq
CYP653B1 Aspergillus oryzae
GenEMBL BAE61541.1
46% to 653A1, 51% to 653A2,
MDYMDYLKEMGLAWHWVPIFVGLLAFYFIMERSTANASRTSLPIVKHFKLLPPFFNRILYVVKAPFLIYY
GYEKYKSKPFRILKLDGDLVVLPQKYLEEVGGLHSRQASLVGAKYKNILGGCTNILINSELPARTVSEKL
NPVLDRQIPRLLFELHHAFSAVVPYCEGRYVPINLYHMILKLVTHSTSRIIIGQRLCRSEQWINTITKCT
YDVRIAVKQLQLVPRFLRRLVAPFLPSVQRLETQLRWIAEQLILPMIQHRRRRELNDPSYKKQEDFLQWM
MDLADNDLDRDPMNLAYGLMITMALAVVQTSTMLITHAMYDLMVHPEYLEPLREEIHETLTNGWIRASLS
DFGAQRRLDSFLHESQRLNPPSEVSAQRVLGRPLTLSDGVTLPKGTHVCFPSGPMSRDPTVVPDPLTFDG
FRWCKDLNAPDGSLTDVSPANLHFGFGGQACHGRFFGAVIAKAVMSRLLAEYDLKFEEGQSGRPENIVNG
EQIMPSISTKVLIKKKNVDI
CYP653B1 Aspergillus flavus
99% to CYP653B1 Aspergillus oryzae
revised
MDYMDYLKEMGLARHWVPIFVGLLAFYFIMERSTANASRTSLPIVKHFKLLPPFFNRILYVVKAPFLIYYGYEKYKSKPF
RILKLDGDLVVLPQKYLEEVGGLHSRQASLVGAKYK (0)
NILGGCTNILINSELPARTVSEKLNPVL (1)
DRQIPRLL
FELHHAFSAVVPYCEGRYVPINLYHMILKLVTHSTSRIIIGQRLCRSEQWINTITKCTYDVRIAVKQLQLVPRFLRRLAA
PFLPSVQRLETQLRWIAEQLILPMIQHRRRRELNDPSYKKQEDFLQWMMDLADNDLDRDPMNLAYGLMITMALAVVQTST
MLITHAMYDLMVHPEYLEPLREEIHETLTNGWIRASLSDFGAQRRLDSFLHESQRLNPPSEVSAQRVLGRPLTLSDGVTL
PKGTHVCFPSGPMSRDPTVVPDPLTFDGFRWCKDLNAPDGSLTDVSPANLHFGFGGQACHGRFFGAVIAKAVMSRLLAEY
DLKFEEGQSGRPENIVNGEQIMPSISTKVLIKKKNVDI*
CYP653C1 Aspergillus oryzae
GenEMBL BAE65194.1, AP007171.1
40% to 653A1 45% to 653A2, 41% to 653B1
63% to CYP653C2 from an indole-diterpene gene cluster
note the other P450 in this cluster is CYP698A1
The ortholog of 698A1/paxQ (698A2) is 4 genes upstream of this gene
14 P450 genes and 2 pseudogenes on this contig
1897240 MDKLTATLAKVNYPSEVENGSMLLVVTLVILFLWFIIPSPVKRSNVSVPTVTLFNPYLPEFLSRVWFNST
AATVIYKGYRQHKDRAFRLLKPDGDIIVLSNKYVEELRQLPLTTLNALEAVFEDHVGKYTTILNDSHLHT
EVIQKRLTPAISRFIPRIIDELDHGFAVEMPECEDKWALIRPYEVFLRLVARAGARVFVGPEICRTEKWL
TASIDFTKNIFMTITLLRPIPSFLHPIIGPMLPSSRSLDTQLRYVQDELLGPEIVKRRQRQASGDPDYEK
PDDFLQWMIDLAQNDKEGDPGNIAHRLLGLTSMAVVHTSAMSITHGLYDLITMSQWLEPLRQEIQEAMPD
WKSSSYSSLVSLRRLDSFLKESQRFNPPGELSFHRVVKKDLVFSDGLRLPKGTHICMASGPIGMDTKYVS
DPTTFDAFRYVDGDKAQSQFVHTSATSMHFGLGRYACPGRFFATFVLKAILSRFLVEYEFRFGPDQVGRP
KNMLLGDKIVPNTSVDVYVRKRTGSRSTA 1899076
CYP653C1 Aspergillus flavus
98% to CYP653C1 Aspergillus oryzae
See fungal pages for seq
CYP653C2 Penicillium paxilli
GenEMBL AF279808
paxP gene
part of an indole-diterpene gene cluster, also includes CYP698A1
MDLSDFHISTPLRYFHEEASLLWKLGVFAVLVYFLLPKPTYKTN
VKVPTVKYMGPWMPEILSRIFFNSHAPTVIYKGYEKFKTSAFKVVKPDGDLVVLSTRY
AEELRQMPSTTLNALEATFTDHVGGYTTILTDSHLHTETIQKKLTPAIGRLIPRMISE
LDHAFEVEFPTCDDQFASINPYTVFLRLVARVGARIFIGDELCREEKWLQASIDYTKN
IFLTIALMRPMPGFLHPIVGRILPSSRSLKDQLSYIQQDLLGPVIKERRRLEASSDSE
YKKPDDFLQWMMDLAQNENESHPDNLSHRLLGITSMAVVHTSAMSMTHILYDLLTMPD
LIEPLRDEIRNEIKDWNKATQADLSRLIIMDSFLKESQRLNPPGDLSFHRVVKKDLTL
SDGLFLPKGTHICMAAGPISKDPDVVSDPDTFDAFRFVKQRTATSGFVSTGPNNMHFG
LGRYACPGRFFAAFVIKLILSRFLMDYDFKFETEHKERPKNLLIGDKIVPNVATPILI
KRRATKA
CYP653D1 Aspergillus terreus
50% to CYP653A3 Aspergillus clavatus
See fungal pages for seq
CYP653E1 Metarhizium anisopliae var. acridum Ma102
CYP654A1 Aspergillus nidulans
AN3274.1
35% to 512A1 54 clan
revised 7/18/07
MILKLIPVTGGAALLLQASALLSFAWLLLAWASRRRRNRLIPGVYVAGLKSGKVPLSQARQAFIHGCA
DLMLEGYQKTQGGLFYVPSPAGERLMIPTKYLDELKN
AANEEVDFTASFSEMFEGRYTTIGQKWHLHPDVVKKSLNANLELIMPDVY
DEIVHAYRSLLTPSHDWQPVRMSEIFTQIISRASNRMLGGKALSRNRDWT
DTSINFTTDTWLASQQLKRYPAWLRPVIQHLLPEMGRVRRHFTVARQVIC
PIVQKRSESDNDTKKPLDLLQMLWEGAEPVDQTPEFMAYTALAISFAAIR
TSSSVPTHLLYDLCARPEYIAPLREEIESVLREEGSIFTKAALNKLLKLD
SFMKESQRFNPLSLLTFGRVIQSDRILHDGLVIPKGTIIGVPAHAISQDG
DFYPSPSTFSPFRFVPSAPGEKTAGFVTTNASSSLSWGYGKHACSGRFFA
ANEIKLIMAYFLLNYDFQFAGGRTERPANYTFELQNMPDETVEVLVRRRK
DGNL*
CYP654A2 Aspergillus clavatus
XM_01273842 note stop codon in genomic seq AAKD03000032.1
1 MILELSPVTGGAALLLQASALLSLALLLLSRVSGRGRNRLIPGVYVTGLNGGKVPLSQAR 180
181 QNFIHGCADLMLEGYQKTKGGLFYVPSPAGERLMIPTKYLDELKNAANEEVDFTASFSEM 360
361 FEGKYTTIGQKWHLHPNVVKQSLNTSLGMVIPAAAAAESSDYFYATSHNRANRADYARYW 540
541 QPVRMADIFTQIISRASNRMLGGKALSRNRNWTDTSINFTTDTWLASQQLKRYPAWLRPI 720
721 LQHVLPEMSRVRRHFTVARQFICPIVQERSESEKGTIKPLDLLQMLWDGAGPADQTPEFM 900
901 AYTALAISFAAIRTSSSVPTHLLYDLCAQPEYIAPLREEIESVLCEEGSLLTKTALSKLV 1080
1081 KLDSLMKESQRFNPLSLLTFGRVIRSDRILHDGLVVPKDTIIGVPVHAISQDADFYPSPS 1260
1261 TFSPFRFVPSTPGEKTAGFVTTNASSSLSWGYGKHACSGRFFAAN 1395
*IKLIMAYFLLNYDFQFAGDRTERPANYSFELQNMPDETVEVLVRRRKDRDL* 187174
CYP654B1 Aspergillus oryzae
GenEMBL BAE64653.1
40% to 654A1 just upstream of CYP682B2
286826 MDLFPRDYLFAGLAVFIFWWIIDHSRHKQRYIRNVPIVGGKANLKRNRQKFVTNSLQILRTGYEE (0) 287020
287082 NNDELFYVPTPIGERLIIPGRYLEELKSADMAVVDFQATFLE (0) 287207
MFEGAYTTLGTHSRLLPQVVRAQLNQYLPDVLPEIQFKVALQIHREIPFNAITECFAKSDWTVINVTELM
AVLVARVSSRMFGGPALSQNREWIEASLRFAHDGFNAAQKLKMWPDTLKFIGQHFIPEVRSIKNTYKIAE
RAIIPLLDEREVDKSKKAHDLLTWMYDQAQGAEKDKKFIAGTLLKVSFAAYHTSAAAPTQLLFDIAAMPE
HIAPLLGEYLSAPRDNNQNISVKGFAQMVKLDSIMKESQRFNPLLLLTFERIIKRDFTLSDGVVIPANTW
IGCAAQAIGMDRKLYPDPDTFDAFRFVAKEEATATSTSVPATKAHYTSANPGSMAFGYGQHACPGRFFAM
MEIKAIIGEILSRFEMRLADGEMRPPSVTFETQHLPHPAGKVLFKRRRCT
CYP654B1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000140.1
99% to CYP654B1 Aspergillus oryzae
MDLFPRDYLFAGLAVFIFWWIIDHSRHKQRYIRNVPIVGGKANLK
RNRQEFVTNSLQILRTGYEE (0)
NNGELFYVPTPIGERLIIPGRYLEELKSADMAVVDFQATFLE (0)
4806 MFEGAYTTLGTHSRLLPQVVRAQLNQYL (2)
PDVLPEIQ (1)
FKVALQIHREIPFNAITECFAKSDWTVINVTELMAVLVARVSSRMFGGPAL 5162
5163 SQNREWIEASLRFAHDGFNAAQKLKMWPDTLKFIGQHFIPEVRSIKNTYKLAERAIIPLL 5342
5343 DEREVDKSKKAHDLLTWMYDQAQGAEKDKKFIAGTLLKVSFAAYHTSAAAPTQLLFDIAA 5522
5523 MPEHIAPLLEEYLSAPRDNNQNISVKGFAQMVKLDSIMKESQRFNPLLL (1) 5669
5722 LTFERIIKRDFTLSDGVVIPANTWIGCAAQAIGMDRKLYPDPDTFDAFRFVAKEEATAT 5898
5899 STSVPATKAHYTSANPGSMAFGYGQHACPGRFFAMMEIKAIIGEILSRFEMRLADGEMRP 6078
6079 PSVTFETQHLPHPAGKVLFKRRRRT 6153
CYP654C1 Grosmannia clavigera
CYP655A1 Aspergillus nidulans
33% to 52F1 52 clan
aspyridone biosynthesis
Nature Chemical Biology 3, 213-217 (2007)
doi:10.1038/nchembio869
Genomics-driven discovery of PKS-NRPS hybrid metabolites from
Aspergillus nidulans. Sebastian Bergmann, Julia Schumann, Kirstin
Scherlach, Corinna Lange, Axel A Brakhage, and Christian Hertweck
See fungal pages for seq
CYP655A2P Aspergillus oryzae
GenEMBL BAE65179.1, AP007171.1
pseudogene
60% to 655A1 partial C-term seq
14 P450 genes and 2 pseudogenes on this contig
1863432 QGDVVQVNNNVMHRD
KDVWGEDADEFKSERWFGLRPYWDFVPHSGGPRRYPAQLLVTTEASYVVARFCQRSKAVENRDVNGYIPI
MRAGPVDSNGVKIAVTPV* 1863121
CYP655A2P Aspergillus flavus
Supercontig 5: 1921861-1922169 -
95% to CYP655A2P Aspergillus oryzae
QSDVVQVNKNVMHRDKDVWGEDADEFKSERWFGLRPYWDFVPHSGGPRHYPAQLLVTTEA
NYVVARFCQRSKAVENRDVNGYVPIMRAGPVDSNGVKIAVTPV
CYP655A3 Neosartorya fischeri NRRL 181
DS027697
join(287915..288538,288596..289115,289183..289287,
289332..289600)
88% to CYP655A1
adjacent to a PKS similar to FUSS polyketide synthase FusA
FusA is used in Fusarin C biosynthesis
Note: this seq does not have an ortholog in A. fumigatus
MMSLATTLSKESLQTLLQHATFLDGIKFVFSAFVIYSCCIIAVD
WIVYEWKRKAHGCGKIPRYPHRDPFFGFDVVLGMAKALRNDYFLVWLNKVHENLPKTF
LVNFVGTRFIYTIEPENMKSMSAINWQDFAVGPMRRNNKATAPFADKGVNTVDGHEWE
FSRFLIKPFFKRETFTDTTRLAIHVDRIFGLLPADGETVNIQPLIQRWFLDVTTESLF
GESIESLVYPERAPICWAMVDVLRGLRLRLQWYKYIWLFRHQAWLDAVDVVHKYLNAH
IDRTYKELDEYKRQGKDPETADRKDLLWYIASNLQDKDALRSQLCLIFVPNNDTTSIF
ISHILWNLARHPEIYEKCRQEVLAVGDAELTFSVLRNMKYLIAILNETHRLFPNGVTQ
VRKCIRDTTLPVGGGPDGKQPIFVHRDIWGPDAEEFRPERWENLRPYWNFVPFGGGPR
RCPAQMLVTAEASYFLARLMRVYKRIEARDSNPYVGVMRVGPSNKTGVQIALFKD
CYP655A4 Uncinocarpus reesii
58% TO CYP655A1 Aspergillus nidulans
See fungal pages for seq
CYP655B1 Aspergillus oryzae
GenEMBL BAE56825.1, AP007154.1
49% to 655A1 C-term in gene model is wrong, revised
MNNAISEPRITPSLRPSPKMQAPTLTSASAEGSDTTAHGCGGCTHFACQPIIMFTLTEYFIAACVWLVLY
KVGNLLWNRHH
YFKQQKARGCGEIKHYRHRDPILGLDFVYTLSKAFKEHRWLPWQQELFAAQGVKTFQAN
FLGSRAIYTSESENMKAMSTTYWREFGLEPLRRGSGAADPVAGPGVSTVDGPMWDFSRNIIKPYFTRDGY
SNLARLEVFVNRLLDLVPTDGSTFDMQPLLQRWFLDTSSEFLFGKTVDSLTHPENVKVAKAMVDTMRGIR
VRLTMSKLMFLHRDPVWMENVKIVRDFVDERIDASLTQLQDVKSGKGTSCTENQPDGRTDLLWDMVQQLQ
DKEALRGQIMAVFIPSNDTTSILISNAIYALARHPHVYQTLREEVLALGDQEITFEKLRG
717492 LRYLRYVINE (1)
717406 THRLYPNGIQMVRIALEDTTLPVGGGPDQSQPIF
717304 IQKGDIVHANRYLMHRDPDNWGPDAEVFRPERWGDVRPLWKFVPFGGGPRICPAHVLVDT 717125
717124 EASYVLLRFVQRFRTLEPRDERPYKAIMRIGPSNLHGVNVAVKTA* 716987
CYP655B1 Aspergillus flavus
100% to CYP655B1 Aspergillus oryzae
See fungal pages for seq
CYP655B2 Fusarium oxysporum
59% to CYP655B1
See fungal pages for seq
CYP655B3P Neosartorya fischeri
51% to CYP655B2
NFIA_045730, NFIA_045740 join
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP655C1 Beauveria bassiana
AM409327
Chembiochem. 2007 Jan 11;8(3):289-297
Biosynthesis of the 2-Pyridone Tenellin in the Insect Pathogenic Fungus
Beauveria bassiana. Eley KL, Halo LM, Song Z, Powles H, Cox RJ, Bailey
AM, Lazarus CM, Simpson TJ.
Gene name tens1, 52% identical to CYP655A1
44% to 655B1
MLPLLDSVSLPYLILSACLSVILLRRFLAHDKGGSKSIAQGCLP
EPRLRQWDPIFGFGIVISQARALRGHRYLEWLRDLHASMPHTKTFSANYGGYRWIFSI
EPEILKAVYATNLQNFGVEPIRQHPPGFQPFAHKGVSTSDGDDWSFSRTLIKPFFERS
VYISTDRIKPFADKFMTLLPDDGETFDIQPLLQRWFLDITSEFIFGKSQDSMTHADRA
EVTWAMADVLRGGRQRAQTHRILWAFNWDWWFEAVEKVHGFLNPYIRSTLKELEERQQ
RIKDGLPVDEERTDLLWSMATMLPDEEELRSQVCLIFVPNNDTTSMFIGHCLYFLARN
SNAWKRLRDEVDAVGDAPITFEMLRNMKYLNGILNETHRLIPNNVTQVRAALSDVVLP
LGGGPNGKAPLDVRKGDIVSVTKTVMYRDPEQWGPDANEYRPERWDGMRGGWHFLPYG
GGPRRCPAQMMVQNESAYMLFRLAQKYSTIVARDPEPFRARMRIGPSSMHGVKIAFYK
CYP655C1 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-2
100% to CYP655C1 AM409327
CYP655C2 Fusarium oxysporum
55% to CYP6455C1
See fungal pages for seq
CYP655D1 Fusarium oxysporum
43% to CYP655C1 Beauveria bassiana
See fungal pages for seq
CYP655D1 Fusarium verticillioides
96% to CYP655D1 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP656A1 Aspergillus nidulans
AN6321.1
related to CYP52 52 clan
MSAVLLGKRYVSTPDPENIKAVLATKFVDFDLGERNAAFRPLLETGVFTQ
DGREWERSRALLRPIFNRAQALPDLLLIEEHVQSRLYRIPRGYDIVNLQQ
LVRDLTLDSAFIHFLA (1)
GRPAKIAGSRRGDFDAEPFSHAFDEARSYLQVRANLGPFRGLVKNTKFVD
DVIVHAAVDEFVYEALEQRRSPAHENRGKLGRGCGN
ESESEGWYDLLSKVADTVSDGVQIRSQLLHVLLAARDT
TARLLSSVFYMLARHPSVWRKLEREVLVEFGLATQGDGKCPLPTYTQLRE
MKYVRAVLNE (1)
ALRLLPPVPTNIRCATQHTFLPRGGGVDGCQPIFVAKKAIVHYS (?)
AEQFRPERW (2)
VPLRRGWGFLPFSGGPRICLGQQKALTEAVYVVVRMVQTFCDIEARDERPWREQMG
LVLSSYYGVKVGLKSRNGGS*
CYP657A1 Aspergillus nidulans
AN5137.1
similar to CYP8 27% to 641A1 cyp7 clan
revised 7/18/07
MNTIQGAYDGLQPKTLVLAAIYILICV
IIFTRILTGLQSYKKTDTAQPRRPRTAPYWIPWFGHSLSFARNHIEFLEN
TRHRLNETVFAIVMSGAKHNVVMSPSMIKSVLTFRGVTTAPLVQHVSRNI
LGDRGVFQKLNPSDRHVFVHNVPNQFMHEPSLSQTSGAAARFIERETPNL
VTFSAAPIDQMLWERPGDVTVIEGKGQQVCEVDFFALIRYFVGTVTTTSL
FGQAILDTFPTLLQDVWSVDDQFATLSMGPPRYLTPGISAAYMARDRLLD
ALAIFHQALLLWDEGKDLGMEFRDLRDLEDVSEPIKNRARMAKDMGLTPQ
ESAPAHLALLWAMNGNSPNIVFYHLLHLYANPTLLEDLRKEIAPFVKVSR
PTREETGFPILEAPRLSIDIDKLCDSCELLKASFYETLRLDSAGLSFRQL
TADLTITESEEEASKAGRLTPESYSLKNGELVIIPHGVIHNDPTHFSNPD
QFDPLRFIRTDPQSGQKYAKSETMTPFGGGMPACKGRAFAEKKILALSAA
IISLWQITPAEGKKFKIPEHRISSAAFLPKNDIRVRMSPRYPS*
CYP657B1 Aspergillus fumigatus Af293
XP_750481.1 also EAL88443.1
51% to 657A1
MDDVREWIWPILLAILLSSCLATRIITGLKSWPDKRIDARLPRSVRVVPYWLPWLGHSIPFGWDHIDFVR
RARDYMNEAVFGIILGGLKHDVVVSPSLTKAILASRGTSSNALINYALEKVGGDQGAIRSLSATDHHIIH
HNIPNLLMREPFLTEASKVAKDITEREAPNLVTFCRSMVDQAPWERRSEAEVTDGQEKLMAEVNLFALVR
NFVGHISTSVLMGQAFLEAFPDLLDDMWTFDNRFPVMALGAPRWLPLPGLSAAYAARDRILDALAAYHQA
FVSWDEGNDPGVKFRDLDDVSESMKQRIRKFKELGLSPRSSAPGHLSLFWALNANSPNVVFWNILRIYSD
PALLEEVRKEIAPFVKVYRPSREETGLPFQEPVKVSLDPDELFRSCPLLKASFYETMRLDSAGLSFREVT
SDLTVTESPEDAAAASLAEPRTYRIKKGGNIVMAHGMVQRDPRLFSNPEQFDPLRFVVTDPDTGARKADM
HTIYPFGAGVSGCKGRALAERMNLLFTAAIISTWDIEPASGKALTVPGHRPSSGAYLPKDDIRVRLRMRV
CYP657B1 Neosartorya fischeri
94% to CYP657B1 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP657B2 Aspergillus oryzae
GenEMBL BAE61082.1
52% to 657A1, 60% to 657B1
MGKDGLSTDGLIQNAWSGSSELVWPLLATVLVLCCIATRIISGFQSRVDSKTEQPQSVKTLPYWFPWLGH
SLSFVWDHVSFTEKSRDYMNASVFGSYMGGTKHNTIVSPSMIKSIMQSKATTSAPLVNRALKAFGDDLGS
LRDLNTTDYQVFHHKLPNLLMREPFITEASETTIQLLKREVPNFVTFCRSVVDQTLWERGSDVEVVDDNG
DKPACEANLFDLVRGFIGNITTTTLMGQAILEAFPSLLDDLWVLDNRFPLLAIGVPRWAPLPGVPAAYAA
RDRILNSLAAYQQAFLQWDDGIDPGVKFRDLEDVSEPLKQRIRTSKNLGLSPRSSAPGHLSLLWAMNVNS
SNIAFWYLVRLYNDPTLLEEIRKEISPYVKAHRPSREETGFPFEEPPRISLNLKGLLDSCPLLKASFYET
LRLDSADMSFRKLTSDLTITESNEDVTNSDRTKPHSYKVYKGESLILHHGVLQNDSRCFSNPSQFDPLRF
IITDPETGEKKANMHTIHPFGGGMSGCKGRTFAERQLLAFTAAMIVMWDIEPMDGSHFTVPRHRQSSGAY
LPKNDIRGKTLWNVNNHGVVVFIRGGRHYLAPPMADRDLSFCITCRIYIVQNIHI
CYP657B2 Aspergillus flavus
99% to CYP657B2 Aspergillus oryzae
See fungal pages for seq
CYP657B3 Aspergillus clavatus
72% to CYP657B1
See fungal pages for seq
CYP657B4 Aspergillus terreus
61% to 657B2
See fungal pages for seq
CYP657B5 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_50091|Aspni1
Supercontig 5: 118325-119770 (+) strand
60% to CYP657B1, no introns
CYP657C1P Uncinocarpus reesii
40% to CYP657B1
model is missing the heme signature
See fungal pages for seq
CYP657C2 Coccidioides immitis
66% TO CYP657C1P, HEME SIGNATURE IS MISSING
note C is found adjacent to the AG pair in the I-helix
This may sub for a Thr that points to the heme. Cys on the other side
of the heme?
See fungal pages for seq
CYP657D1 Histoplasma capsulatum G217B
ABBT01000229.1 Ajellomyces capsulatus G217B
43% to CYP657C1P
See fungal pages for seq
CYP658A1 Aspergillus nidulans
poor match 26% to 640A1 7 clan?
See fungal pages for seq
CYP659A1 Aspergillus nidulans
AN3349.1
poor match 25% to 640A1
lower half 7 clan, revised 7/19/07
MDILDVASSELYTLVRSLVTSPVCQGVLFSLLT
WRLWRFTISPTLQPEDPKEAPYWIPCI (2?)
NQLGNTREPFALTLAGKTMYIIADPKDAAEL
IRNSHSLSTLTTELYTRMGIPQAVIERLFTVYPDAPFNARSNARPVHATD
AMIEMYRAHLSPGAQLDEFLERDVTKRILNAFAKIPGLFNK ()
GIVGAYYGDLIFSLNPGFIAQFMVWEKVNWKLLFGLPSFLSGDMLAARKGLVDGFVAYF
ALPRAERGHENYWVKGVEDSLRWLNVSNEDIARIFMLQTWA ()
ILGNMYKMTFWLVAHILHDAALVNAITAEVRPA(0)
IEIDHHYLSEQCPKLDSLFSEVLRLTLTAPMARDVSETTTVGGRRLREGNRVL (0)
VLYRQLHLDRAT
WGPTPQTLQPDRFLIDSGLKSSIAYRPWGAGKHICPGRFLARSAVFTFVA
YLLAGFEVRLRETGTGKSTRSAFPMADMSRPSPGIANIADGEDVLISVIRRDRSS*
CYP659B1 Talaromyces stipitatus ATCC 10500
ABAS01000005.1 50% TO CYP659A1
MSSSKFFSLLAPTTDDLSSFFFPSFSIAIGLLLC
WRIWRFSIRPLLHPDDPKELPYWIPCEKSSQSCNRK (0?)
272214 NGSSKEPFAITMAGKPIYLLTNPKDIAETYRHEDTLSMDMVVKDLYSRTGISMDKVNRLFIANPES 272411
272412 PHNKGLPRPLHYIDISMEYFRWELSPGESLDRFVNEAAIPAILKAFDFD (1) 272558
GVVDIYYGPALWKINPDFVHSFMMWERVNWKYIFQLPGFLSKDMLEAKRDLVDTFVTYFE
MDRTERDCGNLFVNSVEDTLREAGMGNEEIGRIFFLHSWA
ILGNMYKTAFWIIAHLVYNPSLLEAIRIEVTPAI
EVDHQYLSKDCILLDSLYADVL
RATMSSPMVRDITETTTIGGKKLRKGNRIM (0)
VSYRQLHLNTDVWGPTPELVQPDRFLRDKSLKTNNSYRPWGGGSTLCPGRFFAKKTIFTF
ISVLLVRYSAIHIKEETVGDNKGGRKPAFPRADFSKPIPGIVSPMMGDDISLILRESD*
CYP660A1 Aspergillus nidulans
35% to 636A1 cyp7 clan
See fungal pages for seq
CYP660A2 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_22000016|Aspni1
53% to CYP660A1
See fungal pages for seq
CYP660A3P Aspergillus terreus
51% to CYP660A2 Aspergillus niger
See fungal pages for seq
CYP660A4 Aspergillus terreus
66% to CYP660A2 Aspergillus niger with one frameshift
See fungal pages for seq
CYP660B1 Aspergillus fumigatus Af293
GenEMBL XP_747896.1
43% to 660A1
MDNLSLVVGTLILIAGSALMLRLRHDPREPPVVHNGIPFIGHMIGFVRHGIDYYALQSAKHGLEAFTMDV
LFTKIYVITTPTLVMATRRHHRAMSFEPAITGAARRVTGLKGRGFELLSEKRPGGENLHGAVVNAMRPAL
EGAGLDRMNEKVIGYLLRSVDDLPTAAPFDFHAWCRAALTLSSTDAVYGPLNPYRSKELQDAFWDFEENL
ALLLMDVVQRVTARTAWKARRRLVAAFLDYYRAGGHLDSSQLTYARWETQQKGGATLEDIARLETAAALG
TLSNTVPAMFWFMFNIFSRPELLNEVRDEVARRAVQVDAQGVHTVDLAEIKEKCPLLMSAFQETLRLRSN
TVPIRVIFEDMILDDRYLLKKGGILQMPAHAINRDRTIWGSDADDYDPRRFVKINQSDSRKKANGFLSFG
TSPHVCPGRHFATGEILALIAMLVLRYDIVPAGGVWKEPRTSKSAITSSTGPPAEEFKVLATARKEYEGV
EWAFRVTEGKGKYGLIIG
CYP660B1 Neosartorya fischeri
94% to CYP660B1 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP660B2 Aspergillus clavatus
69% to CYP660B1
See fungal pages for seq
CYP660C1 Aspergillus oryzae
GenEMBL BAE63219.1
61% TO 660C2, 40% to 660A1, 47% to 660B1
revised 3/19/2009
MSDILSIIGLTLLVAFLTSVVFFVQRRKLDPREPPLASSAIPLVGHLASFLYYGLEYFAIAS (2)
RKNRLPAFTMDMLYTKVYIIASPE
LVSAVRRSRNAMSFGPLFANVAENGGGINGRGMQLLRDKEYGGQGVGQQTADSMHPALLGSGLDQMNGKMIAVLKTIIDELASQPDNVVDLYEWCSHAVTVASTDAVYGPLNPYRSESNRRAFWAI ESNL
SLLMMNVVPWITARKPWKGREQLTQAFIQYYQADGHLDSSQLAYTRWKVQHEAGAAIEDIARLEALTALG
ILSNTVPTCFYFLFDIFSRPDLLGKIRDEILDGAFSVDSAGVHTLDLADIRERCPIFVSTFQETLRTRSN
SGQLRVVQKDTLLDDHLLVKAGSIILMPAAVINKHPSVWGADAGTYDPERFSKIDPAQKRSKASGFMSFG
SSPHICPGRHFASGEILALVAMILVRFDVRPVRGTWVEPKGNTKAVAASLPPAVEKVEVKFSETSKFAGV
KWEFRLTPGKGTFGLITG
CYP660C1 Aspergillus flavus
99% to CYP660C1 Aspergillus oryzae
See fungal pages for seq
CYP660C2 Aspergillus oryzae
GenEMBL BAE56717.1, AP007154.1
61% TO 660C1, 38% to 660A1, 56% to 660B1
revised 3/19/2009
382760 MSGSTTIVGLSVVAILASLLFTQRAKLDPREPPLVSSTIPLVGHLISFLIYGIGYFAT 382587
382586 ES (2)
GKHSLPIFTMSILKQRVYIIASPDLLPSVRQNRSTMSF 382413
382412 NPLFTAMAQRAGGIQKPGLQLLREEELGGQGLAKKTVEVMRPALLGNKLDHLNEQMIHAL 382233
382232 KHIVHQVASSPTLPFDLYEWCSDALTVASTDAIYGPLNPYKSEAIRKAFW (2)
DFESNLSLLLVDTLPWLTCRKAWKGREQLVQAFIQFYQADGHLSASSLAYSRWKAQQEAGASLEDIA
RLEILTGIGILSNTVPSCFWLLFDILSRPELLSAIQDEIHQNALSIDSTGTHTLDLADIRGKCPTLLSSF
QETLRTRSNSGQVRVIYQDTLLNDRWLLKAGSTLLIPAPSINKNNSTWGSDAGDFDSQRFTKIAHQTHKK
SKASGFLSFGLSPHICAGRHFATGEILALVALLLVRYDIRPIQGSWTEPKTNAKAVAASLPPAAEKFMVT
AVERPEYKGLEWRTTVTPGKGTYGLIIGLDIYLQLSSVGEEMRRG
CYP660C2 Aspergillus flavus
97% to CYP660C2 Aspergillus oryzae
See fungal pages for seq
CYP660D1 Mycosphaerella graminicola
JGI gene model estExt_fgenesh1_pm.C_chr_10897|Mycgr3
42% to 660A1 A. nidulans
44% to CYP660A2
See fungal pages for seq
CYP660E1 Coccidioides immitis
41% to CYP660B1, 38% to CYP660C1, 38% to CYP660A2, 36% to 660D1
See fungal pages for seq
CYP661A1 Aspergillus nidulans
30% to CYP56A1 547 clan = 56 clan?
See fungal pages for seq
CYP661B1 Aspergillus fumigatus
GenEMBL XM_742987
38% to CYP661A1
shortened at N-term
MILYYLASIPLAIICYLAWYLHVPWDLPSLPRIPFYVSILGLWSSMGQDEIYERWLRKP
LEAHGAVLIWFAGRWSILVTRPDLLTDMFRNEDLYAKAGSQKKIPWSVIATLVGDNII
NSHGDTWKLYTGIMKPGLQKKNFDTAPLLLKSRRFVDEILAEQNSAGRGTGILVNTFV
QQWAVDVMGMSFLDLDLQSLEKPHGTVRLEAIQSVIKLMLFRPLFFNFPDLDQFAWLI
KSRQRAYEIMHEFGDTLMATVLGRIDSDREKGIKPAEEMVVHMLVDAYRDGRLTEKQF
KDNLKIVFLTAHENAQQLVNSMFWEIGKNNEVQTRLRAEILSTNTTTPTSEVVNALPY
LTAVVYELLRLYPPVSQLINRVTVRPAMLGNEIPIPAGTFVGWNAYGVHVNPAIWGPD
ANEFKPERWGRTVGEMHARFRRETVRGTYIPFNAHSRKCLGQGFVLLQMKILLFEVLR
RIEWTVDPGYRLKMTPVSYFLESGRKSTDA
CYP661B1 Neosartorya fischeri
98% to CYP661B1 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP661B2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000007.1
gc boundary After GKNT?
82% to CYP661B1
575568 MSLFYIFAVPLSLIILYLAWYLHVPWNLPRLPRIPFYVSILGLWSDMGQDEIYER 575732
575733 WLRAPLEKHGAVLIWFAGRWSILVTRPDLLTDMFRNEDLYAKAGSQKKIPWSVIATLVGD 575912
575913 NIINSHGDTWKLYTSIMKPGLQKKTFDSRPLLVKSRRFVDKILEDQATAGKQGILVNAY 576089
576090 VQKWAVDVMGVSFLDMDLQ (0) 576146
576245 SLEKPHGAVRLESIQSVIKMTLFRPLFFNFPDLDQFAWLLSSRKRAYEIMHEFGDTLAD 576421
576422 KVLAQMDDATAKGQKPEEEQVVHMLVAAYRDGRLTQKQFKDNLKIVFLTAHENAQQLVNS 576601
576602 MFWEIGKNT (0) 576628
576739 EVQTRLRAEILATGTSNPTADIVNPLPYLTSVIYELMRLYPPVSQLINRVTTAPAMLGGQ 576918
576919 IPIPARTFVGWNSYGVHVNPQVWGADAQEFVPERWGSTVSEMHARFRRETVRGTYIPFNA 577098
577099 HSRKCLGQAFVLLQMKILMFELLRRVEWRVDPGYKLKMTPVS 577224
SHSSFCFVFFYYVACEV* 577278
CYP661C1 Histoplasma capsulatum G217B
47% to CYP661B1
See fungal pages for seq
CYP662A1 Aspergillus nidulans
AN9210.1
33% to 59B1 59 clan
revised 7/19/07
MLALLLVLVALTSYFLVRMRQQRGMFRNLPGPPHHAIWGHFLIMRDIASS
LPPDATPQLFAHLMRQRYGLGDFFYLDLWPLAPPQLVIAHPELATQIVHK
MNLPKESAVMQKWTGPILGEKSMVSANGHDWFIARKSFTPGFQPRKLQQH
IPHIVDETQAFADILREHFHMNDIFKMEDLVARMIFNISAGVILGIKCNA
QRDDDEFLELFRKQAALAPQDFWSRYLYDVSPRRYYRKWSNGRALDRYVG
RLVDQRVVSGPAANPDQKTKYYAIDDAIATSRTLNKNIPHTSSLDKYTRD
MLITSVKTLIFAGHDTSASTLCYTFAAISKHPQVLNTLRKEHNALFGTDP
SAAADLLRDDPNLVNNLPYTLAVIKEALRLWPPTGISLRRGQPDQTLFAE
GKEWPTYPFAVLVNNCATMRREDLFKDAERFYPERHLVNDPTDPYFVPRD
AWRPFEKGPRMCLGQTLALMQLKIALVMTVRTFDFEIVYEEGTFMYQVLD
VTAKPSLGLPTRVKLVE*
CYP662A2 Neosartorya fischeri NRRL 181
NZ_AAKE03000038.1
89% to CYP662A1 Aspergillus nidulans
Note: this seq does not have an ortholog in A. fumigatus
MLALLLVLVALASYFLVRLRQQRSMFK
NLPGPPHHAIWGHFLVMREIASTLPPDATPQLFAHLMRQRYGLGDFFYLDLWPLAPPQLV
IAHPELATQIVHKMNLPKESAVMQKWTGPILGEKSMVSANGHDWFIARKSFTPGFQPRKL
LQHVPNIVDEALAFADVLREHALKDDIFKMEDLGARMIFNISAWVIL (2)
GIKCNAQRGDDEFLELFRKQAALAPQDFWSRYLYDVSPRRHYQKWSNGR
ALDRYVGRLVDKRVVSGPTAVPSEKARYYAIDDAIATSRTLNKSIPPTTALDKYTRD
116369 MLIASVKTLIFAGHDTSASTLC (0)
116479 YTYAALSKHPQVLHTLREEHTTLFGTDPSAAANLLRNDPSLVNNLPYTLAVIKEALRLWP 116658
116659 PTGVSLRRGQPDQTLLADGKEWPTYPFAVLVNNCATMRREDLFKDAERFYPERHLVTDPS 116838
116839 DPYFVPAKAWRPFEKGPRMCLGQTLALMQLKIALVMTVRTFDFEIVYKDGTFMYQVLDVT 117018
117019 AKPSLGLPTRVRLTE* 117066
CYP662A2 Aspergillus terreus NIH2624
AAJN01000191.1
90% to CYP662A2 Neosartorya fischeri = ortholog
See fungal pages for seq
CYP662A3 Aspergillus terreus
52% to CYP662A2
See fungal pages for seq
CYP663A1 Aspergillus nidulans
35% to 546B1 64 clan
See fungal pages for seq
CYP663A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.12.597.1
Necha1/scaffold_12:54695-56385
80% to CYP663A1 probable ortholog
See fungal pages for seq
CYP663B1 Aspergillus niger
JGI gene model e_gw1.10.193.1|Aspni1
43% to CYP663A1
See fungal pages for seq
CYP663B2 Aspergillus clavatus
60% to 663B1
See fungal pages for seq
CYP663B3P Aspergillus oryzae
Supercontig 6: 3781646-3782486 (+) strand
See fungal pages for seq
CYP663B3P Aspergillus flavus
95% to CYP663B3P Aspergillus oryzae
See fungal pages for seq
CYP663B4 Aspergillus terreus
64% to CYP663B2
See fungal pages for seq
CYP663C1 Mycosphaerella fijiensis
JGI gene model gw1.8.660.1 revised N-term
50% to CYP663B4 Aspergillus terreus
See fungal pages for seq
CYP663D1 Metarhizium anisopliae var. acridum Ma102
CYP664A1 Aspergillus nidulans
AN9222.1
37% to 530A1 66 clan
revised 7/18/07
MTMAALDVFNVPYSVPLLGSTVVILIGFIAIKALRVGSRPKGLPPG
PPTEFIWGNTKQIDLFYPQYQYRKWAQQYGPVYTVMLGDTAHVVVSGLRD
VRDIFIKQGASSQNRPPSRFQLLMRDGFFPGLNNGEKWRQSRRMWQAVLN
NSAAKQYLPYQELETRQLLFDLLRAPTEWRDHIERYSNSVAMTMVNGRRI
IDAADPRVKETIQDLYDLAETGVRGAFLDSWPFLWKLPEWMFPVCRQARK
IAAKHREYIWRNYSDVAKRTSQGEVLPSVNHAIQEKLKQGWPGVSEIEGA
EIGHHLLTGTTDTTASTLINWVAAMCLHPEAQKKAQEEIDRVVGPNRLPT
DADAANLPYVQQVIQEAQRWITAVPLSLPRAANAPVHWGKYTIPEETGLI
MNSHALHNDPDIFPEPDKFKPERWEGKPNASSNGDAQLLFTFGAGRRVCP
GQHLAERSLFLVISHWLWGFDTLQATDDDKNKIPIDKDDLRPGFIVCLNP
FPAKITPRTAQHRELIERIWKEELEVSLDESQQWKATPEGIARLLERVGK
*
CYP664A2 Uncinocarpus reesii
58% to CYP664A1 Aspergillus nidulans
See fungal pages for seq
CYP664A3 Coccidioides immitis
66% to CYP664A2
See fungal pages for seq
CYP665A1 Aspergillus nidulans
35% to 530A2 66 clan
See fungal pages for seq
CYP666A1 Aspergillus nidulans
AN1748.1 poor match 534 clan, revised 7/18/07
MLVFTIPLATALIYITHSAFSFLSNLYLVCKTCPSLPRVLFPVSEVNLLY
LALFESRWFNHIRRYWLPTSIADYIADAAFRGRWDVKDRLARKYGGFYLF
VAPGLISCHVGDAEVVSQVVKERKGFVKPVKHLEAFEMYGRNVLTSEGSE
WAYHHRYSASAFSDKNNGLVWQESAIQAQEMLAYWEKKFNASNGSDRFTV
PDVREDILKLSLNIICSAGFGVRLPYRPATSATAERDKDSAEDLFRDAAT
PASGYHFTFRGVMEYMNRSMMSVFIANGILPKWIPRMLVPFFKTDFAAHE
DLKKYLHALIEVTENSEHERHNLLGRLVAARREEQSVRCSGSGPGLSNAE
ILGNTYIFSLAGHETTATTMRFALPLLAIHQDVQDRLYKELEEALRDQPA
NPAEWEYSTVFPRLVTPLC (0?)
IMLETLRLYPPVVSIPKMTTTHMAEITYKGERHCLPPNVRVNLNANVLHY
SEAYWGPDADSFDPRRWDKRNAGSFLARNASARGLSGPGLESPNVHKPVR
GAFIPFSDGLRACMGRKFAQVEFIATLAVIFHRYRVTLVRVGQETEDDAR
KRVEKALRQSSTLITLALGGVVPLAFVRRTGVAAEDDA*
CYP666A2 Aspergillus oryzae RIB40
GenEMBL AP007151.1, BAE56143.1
50% to CYP666A1
join(3144893..3145283,3145344..3145394,3145416..3146254,
3146318..3146493,3146532..3146865)
model wrong, frameshift at 3146521
3144893 MLGIILFSLFISYTAYLGLCFLRHWSLARKIGLPYVSFPISSHN
ILFLSLFETRFVPYVINTWLSPKLADFIYGSAFKTRWAARDRLHRRYGGVYMLITPSV
STCMVCDASVASQICMSRHGFPKPIKQY (1) 3145283
GALEMYGPNIVT (0)
3145445 SEGSQWAHLRRHTATPFNERNSALVWEETIRQTKEMVQYWEDEYSRSSSASEFILTDTRED
ILKFTLNIICSVGYGVKLPFRPGLENSTESAEGLFKDAITPLPGYHFTFRSAMEYLNK
HITSMFIANGLLPKGIPRSVLPFFKKDFDAFDDIGRYLRALVSTAETKETLSQNLIDG
LVRSKQKIDKDQGLDPELTEDEILGNLFVFTIAGHETTAVSLRFALVLLALNQDAQEY
LYEGIREATYDEPRNPVEWDYRRVYPKLVSPLCVM (0)
LETLRMYPPVSGIPRWTGDSAVN
ITYHNQPYLLPPHVYVNVNASGLHYSEEYWGPDAAV FDPKRWDKR 3146521
3146521 NTRSFLAKNKEGGLSGPGLEYDTIHK
PVRGSYIPFSDGFRSCIGKKFAQVEFVVAMAIIFREYRVMLAKSNERETEDDLRRRAE
KALGESTAFITLSMRDEVPLLFQKRCVSKA* 3146865
CYP666A2 Aspergillus flavus
99% to CYP666A2 Aspergillus oryzae
51% to CYP666A1 Aspergillus nidulans
See fungal pages for seq
CYP666B1 Aspergillus fumigatus Af293
GenEMBL XM_741694.1, AAHF01000015.1
44% to 666A1, 48% to 666A2
gene model wrong, correct with genomic DNA from AAHF01000015.1
revised at VM boundary 3/11/2009
MIWSSVLLGLAGLYAFDYFRRLFNNIR
82 LAQRTGLPYTVLPFAGNSLQVKILLSIRWLPYIINHWLPGWLADIINDETYDYRWTVKDR 261
262 RAKKLGKMYMVVTAENIVCHIADASLVTQICNARQSFPKPIWQY (1)
ELLNLYGPNLLT (0)
CEDQAWAHHRRHTAPTFNEKNSALVWEESIRQMTEMLHHWQVAGTSEKLHGFVVASTRGDLLK 543
544 FSLNVLCGAGFGVKLPFKQLPQESTNDPNDVFKDTEKPPEGFSFTFRSAVAYMNLRIMTV 723
724 VLATMVIPKWIPRALMPWLKSDFEAHRDLEAYLRKLISMGKAEKTADKPDNSQNLVQGLL 903
904 MSRNKEAASGSSKGIGLTDLEIIGNMHIFTIAGHETTATSLRFTLLLLALHQDVQDWL 1077
1078 YEGVLEAAHGEPKDVAQWDYHRMFPKLITPLCVM (0)
LEVLRLYPPVVTVPKSTSETPSPLTY 1257
1258 QGKQYVLPPRVNINLNTNCLHYSEQYWGPDVAIFYPQRWDARNQNSFLAKNASTQGLAGP 1437
1438 GLEFPTVHKPVRGAFIPFSDGFRACLGKKFAQVEFIAALSALSRNYKVELADDSPEGRND 1617
1618 AERVLRESTSVLTLSMREDVPIRFQRRKD* 1707
CYP666B1 Neosartorya fischeri
93% to CYP666B1 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP666B2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_12000110|Aspni1
59% to CYP666B1
See fungal pages for seq
CYP666B3 Aspergillus clavatus
71% to CYP666B1
See fungal pages for seq
CYP666B4 Aspergillus terreus
59% to CYP666B1
See fungal pages for seq
CYP667A1 Aspergillus nidulans
29% to 589A1, 534 clan?
See fungal pages for seq
CYP667A2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000032.1
91% to 667A1, one in frame stop codon
178399 MLPLLSSAFTILAALFLYKVIRLAHNVRLARKTGLPYTITPLLETEVLALLFNPLLRYLY 178220
178219 RGYLDRGKGWPRWCRFFVKDWAWEDKRQAHDDLGDLFLCVSPEGIICYSADATMGRDVLS 178040
178039 RRNTFTKPRDKY (1) 178004
177920 KILEPYGMNVATAEGKTYQFHVRITAPPFGDLSGVNSLVWRETIHQTKRLTEAWAKSPPI 177741
177740 EIQKDVNALTLAIISLAGFGRRLEWSKDGENEGIPAGYQLSFLHALQDTLHFMVPILLFP 177561
177560 RWVLIIILNKAALAHAQLDRYLRDIIRDQRAKLSADINHADKESRGNLLTAVVRASMVFD 177381
177380 SEPPSAKSSRLSGERRQGFTEDETMGNIFIYLLA (1)
177209 GYETTANAIIYGLAVLALHQDIQDQVIEEIDSAHARAQSANRSELTYEDDFEFLEYTYGFMYE 177021
177020 TFRLFPGVTLITKMIHQSERIITQGPDGTPKSYDLPAGTRVYLNAPAVHYHPKY*PEPYK 176841
176840 LDPNRWRSSQGEKHVVASDKTRQMKGTLLTFSDGSRACLGRKFAQAEYVAFFATLLRQYR 176661
176660 VSLAPGSDPAVVERDLFGKSAGTITLAPLGNVRLRIQPR* 176541
CYP667A3 Penicillium citrinum
BD294641 PAT 04-NOV-2005
DNAs related to the biosynthesis of ML-236B (compactin)
MAFGPYVAYGALALAAYKIAKLFFFVFQARKTGLPHVLTPFLETEVIAFLLTPILRTVYH
AHLDKETGWPRWCRFIVKDWSWEDKRRAHEEYGDVFLVVSPEGIICYSADAAMGWDVMNR
RKDFTKPRDKYKILEPYGPNVATAEGGTYRFHVRVTASSFNDQSGVNDLVMSETIHQTQQ
LCKLWVKGAAPELQAGVNSLTLAVISLAGFGQRLDVGGKSKKGIKVPQEAKMSFLHAISD
TTKYMVSILLLPGWLLKLTPLRKAHFAHQALDYYLRQLIRDKRKQLVQDINHQDGTSNRG
NLLTAVLRASLTDGDLAKAGGARKDAFTEEETMGNLFIYLLAGYETTANAIMYGLFLLAL
HPEIQEKVICEVDRVWAEANASGRESLSYQHDFDKFYESFRLFPGVTLITKIANGDQPVH
VSNSSGVTTTHILSSGIRVYLSAPGVHYHPRYWPEPNKINPQRWMQNFSNESSGKRVVAA
DRSRQMKGTLLTFSDGARACLGRRFAQAEYIAFFAAFLKGHRVKIRPDHDRQTVWRDIYL
KSAGQITLAPLDTTGLVIERR
CYP668A1X Aspergillus nidulans
Discontinued name see CYP548G2P pseudogene
CYP669A1P Aspergillus nidulans FGSC A4
GenEMBL AACD01000002.1
revised sequence 7/18/07
AN0008.2 poor match 53 clan
may be a pseudogene of the CYP670 family
34% to 670A1, 29% to 628A1,
37% to AL115607.1 Botrytis cinerea partial seq
since this is a probable pseudogene and it matches 62% to CYP669A2P
after MDGPSN, the N-terminal may not be real but it matches
pretty well to an mRNA called an oxidoreductase.
It may be best to exclude the first four lines up to DSPG
WKGHPFTPVVNIVPAFISSLLAFSLSTSQFAKTYRPFKNAPSSLVNHT
VKFAGSSAVHGSHRVSILSSA
SSGSVSGSAPNLLVNAV*TMPGLSA
AAKTDGFSAAIHAMNLVSANLDVMYPDSPG (2)
MDGPSNRNIRSDWYDLLHPQVSSIFTRDRILHQKRRQLWTKALSST(1)
SIQLYTRRILSKIYALES
14773 LIATAADEGKPVLINEVMYWFAFDSVGDFAFSEDFGMLRNEGWHDVIWMFRSALALLGPF 14594
14593 SPAIWMPRLAFSYIPGLWRVKWWFNMLEFCDRCMEQRMK (0)
14416 KTPKESNIASWFLKDHKVHRQNAWLSGDTATLVVAGR
DTNAPTLVHLFYFLARYPEHTEKIW*
ELVSVNAEDPVALAKLPHLNGVINESMRLLPAVL 14054
14053 TFGSRTTQPEGLTVEGTFIPGGVKISAPRYTIGR (1)13952
13871 LKSAFAETHEFIPEWWYSRPDLVKDRRAFAPFGV (1)
GSTSCVGK 13692
13691 SLALAQIRLVTAALVSKYKFQFTPGMGSGEAVEGEMREQLTAQPGHCYLNFIRHVGQE* 13515
CYP669A2P Talaromyces stipitatus ATCC 10500
ABAS01000028.1
frameshift after NIFVY, stop in N-term, pseudogene or seq errors?
62% to CYP669A1P from MDGPGNNN TO THE END
257826 MFRKEVFAIALGILAHRIVFIH
GE*HLRAPSVVVIHLVLGLLIFTREVTLKHDRYNELLLHAMILPSCYLTSLFLSIAMYGL
FFHRLRHFPGPRLVALTKLWHVWKCRDSRGHLVLEEWHQQYGTFVRT (1)
GPEEITIFHPAAHEAMDG
257309 PGNNNVRLDWYDLLYPHISSIFTRDRDLHNARRKMWEHALSRT (1) 257181
ALLYGYYQRILRKVKTPESLVADQYYRPININELMYWFAFDSMGDFAFSEDIGMMRNKAWQKNIFVY
RSATALLGSLSPAIWIARLGFAFIPGLWRVRDWFQMLAFCDQCMEQRMKKEVENRDIASW
FIDDYVLCEKTNPNQHRWLSGDTATLVIAGS (2)
DTTAPSLSVVFYFLALYPDHAEKVYAELLTVNRTDQNALARLPHLNGTINESMRLLLAVL
TFGYRVTPPEGLTIEGTFIPGSTKICTPRYSIGR (1)
LECAYEQPNDFIPERWYRRCELIKDKRAFAPFGV (1)
GRTACVGKHLAMVQIPSVVTSLVSQYRIEFAPGENNGEAVERDMKDQLTARPGKFHLLFMPR*
CYP669A3 Aspergillus niger
JGI gene model e_gw1.4.1307.1|Aspni1
65% to CYP669A1P
See fungal pages for seq
CYP669B1 Phaeosphaeria nodorum SN15
AAGI01000217.1
46% TO CYP669A2P, 45% to CYP669A1P
221162 MAIVPFCLGVIMHLGIFIRGEWHLQAPHIVLGHVLVFTLLLVKQLVSGISTWYGVALPFVV 221344
221345 YLCGLLGSMAVYRLFFHRLRSFPGPRLAVLSKLWHVWLCRDSKNHLVLESWRQKYGT 221515
221516 FVRT (1)
GPSEITIFHPAGLEWLDGPQNRNARSDWYDLLHPSV 221692
221693 QVFSRDPAIQVARRKVWDKAMSLS (1) 221764
AVKQYYQRIKNHVLELESIISAQNSKPIIMNDLLYRMTFNVLKDIGFGQANEEVEDGAS
KLGGSLTIIGPTNPAPWILRMAFALFPGVWNIPHWFKFLEMTQGI (0)
PESVDIASFFLEDAQRKEADMISREAVGGDCGVILLAGS (2)
TSGPSLILLFYCLARWPEHAEKIRQELRNVDYNDMAALSALPHLTATINESLRLYPA
GPTFGSRVTGPEGLNCDGVFIPGGTKVVAPRWSTGR (1)
LEEAYEAAHEFIPERWYSKPELVKDKRAFAPFSM (1)
GRNSCGGKKVAMSQMRLAVAVLVSKYSIRFAPGTTDEMSVENDMRDQLTPLPGDLKLVFEKLE*
CYP670A1 Aspergillus nidulans
29% to 67A1 34% to 628A1 53 clan
See fungal pages for seq
CYP670A2 Coccidioides immitis
85% to CYP670A1
See fungal pages for seq
CYP670B1X Aspergillus nidulans
Renamed CYP5076A1
CYP671A1 Aspergillus nidulans
AACD01000150
See fungal pages for seq
CYP671B1 Aspergillus nidulans
AACD01000104
See fungal pages for seq
CYP671B2P Aspergillus oryzae RIB40
GenEMBL AP007157.1f, BAE58815.1 revised
Join(618168..618393,618483..618641,618711..619251,
619318..619721,619797..620050)
sixth P450 out of 8 on this accession, one stop codon
55% to CYP671B1
MDFISFLHQENFKEVLETDLLQLGVS
AALLGVLLHITIFRTSFCVENHIYNLLGLYATVVLFLFYAYFTITVLSL
MQALGRVALLTTLFNTSLNTSISIYRLFVHRLHPFPGPFACKLT
RFYSAFLAAKNIQYNVELKRLHKQYGDFVRT (1)
GPR*ISILRNTALPLSYGPQTGCRRSTWYGHVDVDDTK
ICMALSHDFNDHRRRRRAWDRAFSIISLSVYEPRVIAQAKKLMAQVEANQGKPLDATT
WSMLFTFDIMGDIGFGKNFGNLTTGKAHPAISAIRDNMRVIAVVSHLPWLLNMLGKIP
GAAAGYQGFFKWCTDQVETKRK (0)
SWDHDEYPQDII
SWILKAFIDNDVSAPPSEPALHDDSRVVVIAGSDTTALALASIIYFLAKHPQILQKLQ
AELDNAMPNGPRSWTYDKAKTICYIDDIIHESLRLRPSVSGGGYRVTPAEGLQIDEVF
IPGDVNVFVPQQLIQTDERYYKFSKEFIPERWGEKKVEWGTDKAPYFLFSLGIYGCVG
KNLAMLSLRVAVSTLAQRYDIRFRTGDILERCIGYIHHFSAAFASCVSPKEIVNTTPF
LRLLQVFFILHISGVKVRT
CYP671B2P Aspergillus flavus
98% to CYP671B2 Aspergillus oryzae
stop codon is conserved in both
See fungal pages for seq
CYP671B3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_9000394|Aspni1
65% to CYP671B1
See fungal pages for seq
CYP671C1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_25000016
Necha1/scaffold_25:46690-48703
45% to CYP671A1, 43% to 671B1 A. nidulans in CYP53 clan
N-term 46% to CF878446.1 tric078xn06.b1 T.reesei mycelial culture
See fungal pages for seq
CYP671D1 Trichoderma reesei
GenEMBL CF878446.1 tric078xn06.b1 T.reesei mycelial culture
CB906402.1 EST
46% to 671C1 (N-term to C-helix)
FSIIYADSCAPTVGGFLVNHKHLLEVLK
MEEALEFFIIDLSSSWRVTTCVSLLAGIASHHLVFRPYEIDTYIWQLIFIYIASMATVFA
TYIHKRGYQVIPASLWTFFIASVYNCSVIASILVYRALFHPLRHFPGPFLAGLSRFYAMG
RMIHSRKGFEDIQGLHQEYGDIVRVGPQELSINRLSVIRAIYGAHAQTTRPPWYAQMSRH
AAXSSLVNTRDVAMHKMRKKVWERALG
CYP671E1 Aspergillus niger
JGI gene model gw1.5.1493.1|Aspni1
43% to 671C1
See fungal pages for seq
CYP672A1 Aspergillus nidulans
31% to 567B1 53 clan
See fungal pages for seq
CYP672A2 Aspergillus fumigatus Af293
GenEMBL XP_751418.1 also EAL89380.1
67% to 672A1
MVLVAMSLPSGPFPELAYPVIPFPVLA VFLVPCLVLLAIRLAPKGPVIKGVPGSFVDLYLCG (0)
IGTKLAFLSGRSTYRFHSLHQSYGNIVRFAPGQATTNTVKALR
QIYSTGTGKGAAFLKTSFYRNISRRNIFTAADPVYHASVRKLFGPSFTPGSMHAHAGVIRECILRLHEVI
RDKLETHNTISLNELLYCHSVDTVSEVLLGKPLGCLKRGKPYFWTEQLPRIFYWATIRDQFEGSGIPTAI
KWLLRRFLRKGIRLRAEQARMRLINEQLHAPHTRRDIMVEVMERSGGSELPEDEIAENFSAIMLAGFHTT
QNALCAVIYLVLTHPEAHVKLVQELQTAFASADDISGDVAAQLPYLNAVITEALRLYPPVPLGGPRVSPG
AYVDGVYIPAGTEICTSLFALHHNPEYFSSPYEFLPERWTEPGSTDRKEAVQPFLIGSRACIAKYFAKQM
LQLTLAGFFLEFEAEHVGKVRDWQRQSRCYAFWDVPDLQVKLRKRLID
CYP672A2 Neosartorya fischeri
94% to CYP672A2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP672A3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_20000080|Aspni1
75% to CYP672A2
See fungal pages for seq
CYP672A4 Aspergillus oryzae
Supercontig 18: 1723786-1724196 (-) strand
See fungal pages for seq
CYP672A4 Aspergillus flavus
79% to CYP672A2 Neosartorya fischeri
99% to CYP672A4 Aspergillus oryzae
See fungal pages for seq
CYP673A1 Aspergillus nidulans
29% to 57a1 53 clan
See fungal pages for seq
CYP673B1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.10.303.1
Necha1/scaffold_10:98331-99989
46% to 673A1 Aspergillus nidulans
See fungal pages for seq
CYP673B2 Fusarium oxysporum
58% to CYP673B1 Nectria haematococca
See fungal pages for seq
CYP673B3 Fusarium verticillioides
86% to CYP673B2, possible ortholog
See fungal pages for seq
CYP673C1 Aspergillus oryzae
GenEMBL BAE61747.1
43% to 673B1, 37% to 673A1
MTLLQNIVSETPLAAGSALLTAIIVAYVIYQRYLHPLAKYPGPFLASITDLWQVHQFLSLQQPYNLTALH
ERYGPIVRYGPDKLSITHESAVPTIYQKSAKSMPKTEFYDAYGAAHPNVFGMRDEVMHSVRRRHMSHSFS
LSYIKEMEEYLDLNIRILKDKIRYHSEIGEVFALKKALHYYMIDVLGELAFSRSFGVQEADDESRIPPVI
EHSLLAAVTGAWPTMTMTLKRWLPYMPHAGLRRLFAGRKACADLASSSVQRRLRDLNDGESSVGVQNRKD
ILTNLIKAKHPETGERLTQTDLETEAFGFIIAGTHTTSATSTLLFYHLLHNPDFMRKCTEEIDSNLPSLG
PSETAYSITAAEASLPFLRNCIRENFRITPVFTMPLARRITDPAGVTIEGEHLPQGTSVAVCNHAFHHNP
VVWGEDHNIFNPNRWNDPNVGAKARLLMHFGLGGRQCIGKAVATTNIYKLLSTLLKEFTFELADEQERVD
VDKGLYKGRIPKLFSVGISDLQGPLLVRARVR
CYP673C1 Aspergillus flavus
99% to CYP673C1 Aspergillus oryzae
See fungal pages for seq
CYP673C2 Aspergillus niger
JGI gene model e_gw1.1.1529.1|Aspni1
70% to CYP673C1
See fungal pages for seq
CYP673D1 Mycosphaerella graminicola
49% to 673A1, 47% to 673B1, 39% to 673C2
See fungal pages for seq
CYP674A1 Aspergillus nidulans
32% to 532A 53 clan
See fungal pages for seq
CYP675A1 Aspergillus nidulans
AACD01000079
See fungal pages for seq
CYP675A2 Aspergillus oryzae
GenEMBL BAE55129.1
63% to 675A1
revised 3/23/2009
MDLLRLRDRSLLGQGALVAFVTYWAVWIIYTRWFHPLAKFPGPFWASVTRAWTLLHVLHGDAEKRQMKLHAKY (1)
GSVVRIAPNELVTSEPEAIQTLYGARSFTAK (0)
TDFYFAFRPPW (1)
ARFPDHFSSEGGKQHGERRRIVSHVYTMTSILQSEKYIEKCIAVWLEKLGQMADRKESFDLWIWTRMYAYD
VIGELYFSKMFGFLQAGHDHLGYIDATEDLVPIQFLAANMPTYVRGLFMLTGILFPKVRRALRALGDLTD
ATNAMLKDRLAAIQSDSEDKPQRHDILGKLLEISQKRGKELDFVLDDIKMESFGAFFAGSETTALTLSGI
LYHILRNRSVYEKLTAEIDTAVQCNQLSTPHISYNDAIKLPYLTACIREGIRMHPITGVSFPRHAPSSGC
TIGGYYIPPNARIGVNPGVMHFNKTVFGEDADQFRPDRWIDGDVSKMDRYIMQFGMGARTCLGKNISMCE
IYKAIPELLKFYTFELAGDEDMQTTSYWLYKPVAIDVNVRRR
CYP675A2 Aspergillus flavus
97% to CYP675A2 Aspergillus oryzae
See fungal pages for seq
CYP675A3 Aspergillus terreus
58% to CYP675A2 Aspergillus oryzae
See fungal pages for seq
CYP675B1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.22.151.1
Necha1/scaffold_22:515970-517756
49% to CYP675A1
See fungal pages for seq
CYP675C1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.27.138.1
Necha1/scaffold_27:47233-48946
46% to CYP675B1, 42% to 675A1
See fungal pages for seq
CYP675C2 Fusarium verticillioides
57% to CYP675C1 Nectria haematococca
no F. oxysporum ortholog found
See fungal pages for seq
CYP675D1 Fusarium oxysporum
42% to CYP675C1, 42% to 675C2
See fungal pages for seq
CYP675E1 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_160602
42% to CYP675B1 Nectria haematococca
42% to CYP675C2 Fusarium verticillioides
39% to CYP675A1 Aspergillus nidulans
See fungal pages for seq
CYP676A1 Aspergillus nidulans
36% to 629A1 53 clan
See fungal pages for seq
CYP676A2 Aspergillus niger
XP_001399153.1
JGI gene model gw1.2.1506.1|Aspni1
62% to CYP676A1, revised 2/10/2009
See fungal pages for seq
CYP676A3 Aspergillus clavatus
73% to CYP676A2, 63% to CYP676A1
See fungal pages for seq
CYP677A1 Aspergillus nidulans FGSC A4
AACD01000158.1 revised
MDAYTSLLALAGALISYSLSYVCYTFYWHPLARFPGPPLAALTRFYRAYI
DISWKHSFVHHLGELHKKY (1)
GDIIRIGPNE (0)
LHFRSPAAYLEIFNPANRWDKEERLYHSFGEDRSSFG
YLRYAEAKERKDILSRRFSRKAVQDAQKIVEGI (0)
VLDLCKTLGQNSEEAVDLFYAFRCMSVDVIT (1)
YLCFANSVNAVHAPKYESPLLLAMDASMTVFPAFKHFGFYKEMIMNC
PPKLSKILSPATAGLVDLQTLLKAQIEDLTSDPSQLEKLPHNTTIYHELLRP
EAYRTKTQPSKGSLYEESQALMFGGADTTGMTLMHGCFYILQEKSRGIYE
RLKTELVEAWPSLDGAAPTWEELEKLPYLTAVIKESLRMSPGVASPLPRV
VPKSGAVITKTHIPGGTIVSQSSHFVHTNPDIFEDPHSFIPERWLGEKGK
SLDKWLLAFSRGPRSCLGQQLAWAELYLTYAHVFRKFDLQIDPSR (2)
SPNELKWKDTFLAHYLGPHLKAKLTPVIS*
CYP677A2 Coccidioides immitis RS
GenEMBL AAEC02000027.1
64% to 677A1
1175231 MKPFVLTEFGFQSHWILLAALYLAGWAVYQGIK
1175330 TLYWHPLAKFPGPRIGALTRLYKTYVECVAQGSFVHLLEEHHARY (1)
GDIVRVGPNE (0)
LHFSNPATYLEIYNPSNRWDK 1175686
1175687 EESLYHSFGEDRSSFGFLTYKEAKERKDVLNRMLSRKAILGSQGIVQEK (0)1175833
1175898 VVELCKSFERKKNSTVNLFYAFRCMSIDVIT (1)
YLCFGSSVDAIN 1176077
1176078 APDHQAPIIIAMDASLPVFVRFKHSAFYKSMIVNCPPAISKIVSPLTAGLVDLQQ (0) 1176242
1176296 LLKGQIKEMTEDPSTLEKLPHSRTVFHELLRPEAYKSRTVPCADSLYEEAQALMFGGADT 1176475
1176476 TGTTLMHGTFYILKQPEVYRRLKEEIHAVWPNLNTLPDLTDLEKLPYL (0)
1176476 TAALKESLRMSPGVASALPRIVPPSGAKISGQFIPGG (0) 1176790
1176862 TVVGMSSHFVHRSETVFEKPNEFIPDRWLGDKGSQ 1176966
1176967 LDKWLFSFSHGPRSCLGQN (2) 1177023
1177088 LAWAELYFCFAHLYRKFDIEMDPSS (2)
PRDLQWRDRFL 1177267
1177268 PEYIGPHLKAKITPVAS* 1177321
CYP677B1 Mycosphaerella graminicola
47% to CYP677A1 Aspergillus nidulans
See fungal pages for seq
CYP677B2P Mycosphaerella fijiensis
synt_with_mycgr.14__52
58% TO CYP677B1
See fungal pages for seq
CYP677C1 Aspergillus terreus
48% to CYP677A2
See fungal pages for seq
CYP678A1 Aspergillus nidulans
poor match 53 clan
See fungal pages for seq
CYP678A2 Aspergillus clavatus
59% to CYP678A1 Aspergillus nidulans
See fungal pages for seq
CYP678A3 Neosartorya fischeri
58% to CYP678A2 Aspergillus clavatus
Note: this seq has no ortholog in A. fumigatus
See fungal pages for seq
CYP679A1 Aspergillus nidulans
AACD01000170.1
See fungal pages for seq
CYP680A1 Aspergillus nidulans
AACD01000006.1
See fungal pages for seq
CYP680A2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_2000610
Necha1/scaffold_2:1945379-1947146
49% to CYP680A1
See fungal pages for seq
CYP680A3 Aspergillus niger
JGI gene model e_gw1.1.1307.1|Aspni1
63% to CYP680A1
See fungal pages for seq
CYP680A4 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_71000001|Aspni1
67% to CYP680A1 aa 316-512 seq gap upstream
See fungal pages for seq
CYP680A5 Aspergillus clavatus
AAKD03000006.1 895518-893676 (-) strand
63% to 680A1
See fungal pages for seq
CYP680A6 Aspergillus terreus
67% to CYP680A5
See fungal pages for seq
CYP681A1 Aspergillus nidulans
34% to 551A1 53 clan
See fungal pages for seq
CYP682A1 Aspergillus nidulans FGSC A4
AACD01000135.1 revised 7/19/07
MAILWSYLFSSYAVIIGLVTSVYLLGLGIYRLFLHPLAKFPGPKYAALGR
WHEAYYDIYLSGKLIFWIEEQHKKYGPVVRIAPDELHILDADLWETIYTK
AGRVDKYDRMSSRFGNDTSVLATIPDSLHRVRRGALNPFFSRQRILGLQD
IIRQKLNIFIKRVEEYKALNAPMPINRGFLAFSEDVIMQYCFGHDYAALN
KRGWAPTLHDPIVNVTLAGNTALHFPIVPKIMNVLPQSWIAKLDPVYVPI
FQMQRIREIKDSLTGESPKIDKQTVFSDLIQGDLPASEKADRRLQDEAQL
VIGAGLATTGWALTVGTFYLLSNPKVLARLRRELDEAIPARNPENPSGAL
EWAELEKLPYLTGVIKEAVRLSHSTTSRNVRRLPKPITYKDWVIPPRTPV
SMTIPFLHLDEDIYPEPKSFIPERWLDNPKTKNGAPLERYFVGFGKGTRSCLGLN (2)
LAWCELYLVFAAFFRFFDFELYETDFSDIELQHDFFLPFPKWDSKGVRVFVKERSA*
CYP682A2 Coccidioides immitis
64% to CYP682A1 Aspergillus nidulans
See fungal pages for seq
CYP682B1 Aspergillus nidulans
AACD01000150.1
See fungal pages for seq
CYP682B2 Aspergillus oryzae
GenEMBL BAE64654.1
56% to 682B1
MTLISLSLLALSLWIIIRVLVIIYRLAWHPLARFPGPKFAAATSAYEFYFDAIKGGQYTFEIGHMHKKYG
PIVRISPHELHINDPGFIEELYPGPGKPRDKYAYATGQFGIPDVCSLVLTPYDLSSVFGAVSHDLHRMRR
GALSPFFSKAAVTKLEPVIYSAVDKLISRIEEVVESTGFVDLTMAFSCMTTDIVTQYAFAESSRFLENPD
FTPNFHEAILAGTRMGSWARHFPILFPVLRSIPIDILSRMSPETGVFLRWQESMRKKVSEIWQDQSALPV
KDKNVSPFGSTIFHELFHSDMPDSEKHPGRMWQEGQIVIGAGTETTAWTLTATTFFILDNPNILSKLRKE
LAATMPNRYEKPSCRELEALPYLIIIQEGLRLSFGVATRLQRINSEAPMIFRQKKTNDTIEEKVWEIPTG
TPVGMTAALVHLNPELFPDPHEFRPERWLDQDGQLHRGLDKYILSFSRGSRQCIGINLAYSELYMGIGIL
IRRLGDRMQLFETDRTDVDMVEDCFVPVPRRESNGVRVRLSAQ
CYP682B2 Aspergillus flavus
AAIH02000253.1
12469 MTLISLSLLALSLWIIIRVLVIIYRL
12547 AWHPLARFPGPKFAAATSAYEFYFDAIKGGQYTFEIGHMHKKY 12419
12363 GPIVRISPHELHINDPGFIEELYPGPGKPRDKYAYATGQFG
IPDVCSLVLTPYDLS
SVFGAVSHDLHRMRRGALSPFFSK 12019
12018 AAVTKLEPVIYSAVDKLISRIEEVVESTGFVDLTMAFSCMTTDIVTQYAFAESSRFLENP 11839
11838 DFTPNFHEAILAGTRMGSWARHFPILFPVLRSIPI 11734
11657 DILSRMSPETGVFLRWQE
11533 SMKKKVSEIWQDQSALPVKDKNVSPFGSTIFHELFHSDIPDSEKHPGRMWQEGQIVIG 11360
LTATTFFILDNPNILSKLRKELAATMPNRYEKPSCRELEALPYLI 11136
IQEGLRLSFGVATRLQRINSKAPMIFRQKKTNDTIEEKVWEIPTGTPV 10925
10924 GMTAVLVHLNPELFPDPHEFRPERWFDQDGQLHRGLDKYILSFSRGSRQCIGI 10766
10707 NLAYSELYMGIGILIRRLGDRMQLFETDRTDVDMVEDCFVPVPRRESNGVRVRLSA* 10537
CYP682B3 Uncinocarpus reesii
53% to CYP682B1, mid region has some questions remaining
See fungal pages for seq
CYP682B4 Coccidioides immitis
70% TO CYP682B3
See fungal pages for seq
CYP682C1 Aspergillus nidulans
AN6787.1
34% to 579A1 35% to 58A1 53 clan
revised 7/19/07
MELLRLLLDHPYAVAGAAVSVYIASIVIYRLYLSPIAHFPGPRLAALTVM
YEFYWEAIRHGKFTFHIGELHKKY
GPIVRISPTELHVNDPEYYEVIYSRDSPRNKYPYYQRTFNAPYAL
ITAEDHYRHRLLRSQLNPFFSIQRIRQLEPTLKALVDKLCRRLEELKGTG
QPIDIEYPLTCYTTDVITDYTMGEGGYHYLDEPDFIPQWQHMLCGTAKTL
VFIRPIAFLLPVLVAMPEALTAWLNPGMELFFAFQHRCRKRIAEITKRHR
ENGPLETKDGRQNLFDNVLNSNLPEQEKSEARLAQDMQVFVSAGAETTAK
AMSYIMFYLHNEPALLQRLKDELAPLGNDPSLVQLEQLPYLTSVMLEGLR
LSYGVTARLPRIAPYNALKYKDWTIPPGTPISMSCLLMHHDESIFPDSYR
FNPDRWMDPTERKHLEKYMVAFSRGSRMCIGMHLAR
SEILLVISSLLRRLNFELYETTVEDVRVAHDIFIPFVKLDSKGVRFLIK*
CYP682C2 Aspergillus fumigatus Af293
GenEMBL XP_748206.1 also EAL86168.1
69% to 682C1
MELFRLLLSHPVSSAVALGAVYLLWVVLDRLYLSPIAGFPGPKLAALTHLYEFYWDTICCGQFTFQIGRL
HEKYGPIVRISPTELHINDPDYYEVLYSRDSPRNKYEYYQKTLNAPLALLNTIDHHLHRQLRAQLNPFFS
STRIRRQEPAIKALVNKLCRRLDELKNTGQPLNIEHALTCYTTDVITDYSMGDGYHYLDAPDFIPQWHGT
LNGTAKTMVFIRPVAWALPLLLALPEAVTAWLNPGMELFFDFQRRCRKMIKRIVAAHNEKGNQGVQNEGF
VNIFDDILRSNLPAKNKSETRLAQEMQVLVSAGAETTAKAITYILFYLLNDPETMAKLKAELETVGEDPA
LVQLEQLPYLTGVMLEGIRLSYGVSARLPRIAPYNALKFRDWTIPPGVPVSMSCLLMHHNETVFPDSHRF
KPERWLDPAERKRLEKYMVAFSKGSRQCIGMHLAKAEILLAVSTLLRRMDLELYETTVEDVAIKHDIFIP
FPRMDSKGVRVLIKG
CYP682C2 Neosartorya fischeri
97% to CYP682C2 Aspergillus fumigatus = ortholog
See fungal pages for seq
CYP682C3 Aspergillus clavatus
82% to CYP682C2
See fungal pages for seq
CYP682C4 Aspergillus terreus
78% to CYP682C1 Aspergillus nidulans
See fungal pages for seq
CYP682D1 Aspergillus nidulans
CYP682D2 Aspergillus oryzae
GenEMBL BAE55187.1
68% to 682D1
MVHPSVLVEALVMFRPIAQFLLFPPFCMFQFLFQPWIIALAGAGYLISLAVYRLWLSPLAKFPGPKLAAL
TLWYELYYDIYCEGQYTFQIIRMHEKYGPIVRISPWELHISDPDYYEVLYSRDSPRNKYEYYTRQFGLTK
TAMATVDHYHHRLLRSNMNPYFAMTRIRKLEPLIQGLVDKLCDRLREFKGTGTPVALQYPFTCFATDVVT
DYTMGAGFHYLDEPDFVPRWSRTLSGVAKSGVYIKPFPWLIKVFNALPESWLSWLNPEMDLTFHFQRRCR
EVIASIMEEQNANGYDKVKSQFSHPTFFHDVLNSNLPPEEKSPERLWQEVQVVVGAGAETTGKALTWTMF
YLLHSPDKLQKLREELNQLDPDRTATLLDFEKMPYLTSVILEGLRLSYGLSTRLQRVAPDRALQFREWSI
PAGTPVGMSSTLMHHDERIFPDSHKFIPERWLDLEQRKHLEKYMVAFTKGSRQCIGMNLARSEILLALPK
VLRELDFELYETTLEDVTLAHDMFLPFPKMDSKGVRVLIK
CYP682D2 Aspergillus flavus
99% to CYP682D2 Aspergillus oryzae
See fungal pages for seq
CYP682D3 Uncinocarpus reesii
67% to CYP682D2 Aspergillus oryzae
See fungal pages for seq
CYP682D4 Coccidioides immitis
81% to CYP682D3 Uncinocarpus reesii
See fungal pages for seq
CYP682D5P Aspergillus oryzae
50% to CYP682D4 N-term part, 100% to CYP682D5P Aspergillus flavus
See fungal pages for seq
CYP682D5P Aspergillus flavus
50% to CYP682D4 N-term part
See fungal pages for seq
CYP682D6 Aspergillus terreus
63% to 682D2
See fungal pages for seq
CYP682E1 Aspergillus nidulans FGSC A4
AACD01000079.1 revised 7/18/07
MLSLDLVFSFPAWALLLVLTLLYTLYLA
TTRLLLSPIR
HIPGPTLAALSFWPEFYYDVVQRGQYFRQIDKMHQTYGPLVRINPFEIHI
QDPSFYPVLYTGPTRRRHKWLWAARMFGNNTSAFATVRHEHHRLRRSALN
PLFSKSAIQRLTPHLQHTLARLCSRLDGFAFTRQDVDLGIGLTAFAADVI
TEYCFGQSLELIGKDNFGKEWIDMVSAPSELGHLVKQCPWILVVCKWAPKALVRALLPGVALLFQIQE (0)
RMSAQIQPLVDRAAAVDKPA
DPLTVFDFLLSSTLPQHEKTVDRLKGEGQTLIGAGTLTTGNALKTIIFHVLNDPDI
FRKLRAEVDGALENMDILSMSDTAYLERLPYLSACIKEGLRISYGVTHRL
QLIAEEPLIYSGVTIPAGTPVGMTSIFMHDNPVVFPQPREFRPERWFEAD
FETVQAMNRHFVPFSKGSRMCLGMNLAYAEIYLVLAVLFRRYEISLSGVT
REDIEMAHDFFDPAPKEGARGLIVQLQKRG*
CYP682F1 Aspergillus niger
XM_001397274
43% to 682C2, 42% to 682D2, 41% to 682D1
35% to cytochrome P450 Myrothecium roridum tri4 gene CYP58A2
60% to DQ054596 mid region fragment of Aspergillus ochraceus in
ochratoxin synthesis
MSIDTLLYTSLAVGAVYLASVALYELYWSPLAHIPGPKLAACTR
LYEFFYDVVCGGQYTFKIADLHKQYGPIIRISPREIHIHDPNYYETLYATNSPRNKDP
WFTAHFGVDESAFSTLDYRLHRSRRAMIAPFFAKARMDGAQPLIKANLAKLIRHLDAH
ASSQSVLKVEVAYNSFTGDVITGYTSYRSFEYLETTDMVPIWSETVRNLVESGMLSRH
LPGFFPLLAWAGSRCIAAVYPKLLPVIAFRMKCAQEVNFMWTNSEEGKKEAIQSGCSE
PALFPELVSRASSAPDITEERLLHEFITIVAAGTETTAHTMTVCTFHIAHNQSILDKL
REELDNRFHSNADMDLQTLEQLPYLTGIIYEGLRLSYGLSHRLQRISPIDPLKYKDIA
IPPNTPVGMSSALMHHDESIFPQSHEFIPERWTDPNDRRRLNKYMVSFSKGSRQCIGM
NLAFAELYLGIATLFRRYDMKLHDTTLDDVQLHGDKMLPRAKNGSKGVRVTLRRAQSVG
CYP682F2 Aspergillus ochraceus
DQ054596
P450 in the ochratoxin biosynthesis pathway
60% to CYP682F1 (mid region)
EVQRIQSLIQSKLQKLNTRLSEYAHSGEPLKVDVAFNCFTADII
TSYTSFRAFNYLDDPEMVPIWSETIKNLVEIGMIARHLPGFFPLLASMGMKWVKRVYP
KLLPVIAFRMKCAQEVNFMWENEEEAKLDFEKNRLSQEPALFQEMVAKAPDT
CYP682G1 Aspergillus niger
JGI Gene model e_gw1.2.437.1|Aspni1
44% to CYP682B1
See fungal pages for seq
CYP682H1 Mycosphaerella graminicola
44% to CYP682B1 N-term from JGI model e_gw1.2.1462.1|Mycgr3
See fungal pages for seq
CYP682J1 Uncinocarpus reesii
40% CYP682B1 Aspergillus nidulans
top hits are all CYP682s and CYP58s
See fungal pages for seq
CYP682J2 Coccidioides immitis
85% to CYP682J1 Uncinocarpus reesii
See fungal pages for seq
CYP682K1 Uncinocarpus reesii
44% to 682D2, 46% to 682D1
See fungal pages for seq
CYP682K2 Coccidioides immitis
68% to CYP682K1
See fungal pages for seq
CYP682K3 Histoplasma capsulatum G217B
60% to CYP682K1 Uncinocarpus reesii
See fungal pages for seq
CYP682L1P Coccidioides immitis
pseudogene
44% to CYP682A1 Aspergillus nidulans
45% to CYP5095A2 A. niger
See fungal pages for seq
CYP682M1 Fusarium oxysporum
42% to CYP682H1
See fungal pages for seq
CYP682N1 Aspergillus clavatus
39% to CYP682M1, 42% to CYP682G1, 41% to CYP58E1
some overlap between CYP58 and CYP682 families
See fungal pages for seq
CYP682P1 Metarhizium anisopliae var. anisopliae Ma23
CYP682Q1 Metarhizium anisopliae var. anisopliae Ma23
CYP682-un1 Aspergillus oryzae
pseudogene 99% to CYP682-un1 Aspergillus flavus
See fungal pages for seq
CYP682-un1 Aspergillus flavus
pseudogene 47% to CYP682H1
See fungal pages for seq
CYP682-un2 Aspergillus terreus
41% to CYP682C2 Neosartorya fischeri C-term fragment
See fungal pages for seq
CYP682-un3 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_32000094
45% to CYP682A1 Aspergillus nidulans
45% to CYP682L1P Coccidioides immitis
See fungal pages for seq
CYP683A1 Aspergillus nidulans
poor match 53 clan
See fungal pages for seq
CYP684A1 Aspergillus nidulans
AACD01000005.1
See fungal pages for seq
CYP684A2 Aspergillus oryzae
GenEMBL AP007164.1e, BAE62328.1
51% to 684B1
Fifth P450 of six on this accession
CDS complement(join(1693125..1693300,1693352..1693428,
1693479..1694095,1694146..1694531,1694582..1694720,
1694773..1694844))
MDSGFIRDNIPAIASIAVLVYVLSV (0)
VYRSQRSHLSYLP
GPWYTKFTDLPLRYKVVTGQRPRYVHALHDKY (1)
GPVVRIGPDEVDVSDISGAREIHRIGSGFLKS
PWYSLLNRKDTQSIFTTTDPKFHNAHRRLLSSPMSELSLKSMEPLIDARVRLTIQKMQ
EEMKTRGVADVYKWWFFMATDIIGEITFGESFRMLEKGK (0)
KNQYVKDIEMISVIGGIRA
SFPILVKLATLLPLPIFKEVNASGNRVFGYATESINRYKRLLAENPENPKPTVFTKLY
NAGEEGLPDNEIRDDAQSFIVAGSDTTANTLTYLVWAVCRDPQIKKKLVDELAEIRDD
FTDEDLRSLPYLNQVINEALRLYPAVPSALPRSVPPKGTTMGGHWIPGGSTVSTQLYS
LHRDPVAYPDPEK (2)
FEPSRWASPTKLMKDAFMPFGAGSRN (1)
CIGLHLAKIELRLATGYFFRYFPNAKLSSKYDFNDNDMEQMLFFLMSPKGKRCLLEV
CYP684A2 Aspergillus flavus
100% to CYP684A2 Aspergillus oryzae
See fungal pages for seq
CYP684A3 Aspergillus niger
JGI gene model e_gw1.8.1151.1|Aspni1
66% to CYP684A2
See fungal pages for seq
CYP684A4 Aspergillus terreus
53% to CYP684A2 Aspergillus flavus
See fungal pages for seq
CYP684A5P Aspergillus terreus
54% to CYP684A2
50% to CYP684A4 Aspergillus terreus
See fungal pages for seq
CYP684A6 Aspergillus terreus
54% to CYP684A2
See fungal pages for seq
CYP684B1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_8000032
Necha1/scaffold_8:72793-74540
39% to 62B1 Fusarium graminearum, 40% to CYP5040A1
51% to Aspergillus oryzae 684A2 (in CYP53 clan part D)
See fungal pages for seq
CYP684B2 Fusarium oxysporum
68% to CYP684B1 Nectria haematococca
See fungal pages for seq
CYP684B2 Fusarium verticillioides
86% to CYP684B2 Fusarium oxysporum = ortholog
See fungal pages for seq
CYP684C1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_11000386|Aspni1
44% to CYP684A2
See fungal pages for seq
CYP684D1 Mycosphaerella fijiensis
JGI gene model e_gw1.8.467.1
43% to CYP684A2 Aspergillus oryzae
See fungal pages for seq
CYP684E1 Metarhizium anisopliae var. acridum Ma102
CYP684E1 Metarhizium anisopliae var. anisopliae Ma23
CYP684F1 Metarhizium anisopliae var. anisopliae Ma23
CYP684G1 Cryphonectria parasitica
CYP684H1 Cryphonectria parasitica
CYP684J1 Cryphonectria parasitica
CYP684K1 Botrytis pseudocinerea
No accession number
Saad Azeddine
Submitted to nomencalture committee July 5, 2012
53% to CYP684A2 Aspergillus oryzae
52% to CYP684B2 Fusarium verticilliodes
CYP685A1 Aspergillus nidulans
28% to 613A1 613 clan
aspyridone biosynthesis
Nature Chemical Biology 3, 213-217 (2007)
doi:10.1038/nchembio869
Genomics-driven discovery of PKS-NRPS hybrid metabolites from
Aspergillus nidulans. Sebastian Bergmann, Julia Schumann, Kirstin
Scherlach, Corinna Lange, Axel A Brakhage, and Christian Hertweck
See fungal pages for seq
CYP685A2 Neosartorya fischeri
85% to CYP685A1 Aspergillus nidulans
By comparison to 685A1 with no intron at PSSK/LRYG a gc boundary is
predicted
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP686A1P Aspergillus nidulans
GenEMBL AACD01000154 AN8510.2
Revised sequence, now a pseudogene
pseudogene two stops and two frameshifts
33% to 613A1 613 clan? Similar to CYP5082 family
MAAVQFPIEADPQWPSNGTSPVQSLPGPFNTRF*ELFHHDQPQPPRI
PILALTARYRAVDRKRSLTGPDYVWPFGNFRHMFAESRALSHKW
RKEYGDIYRIWTGFYSEV (2)
VISTPADIATFYSDSASHKKTLALRSN*VVNKLLGACVGFTNGX
RWKRNRKAFDPLLANNVAVKHNSRSHQEAAEFVSSIATTRVDG
GSNEETMIIKAAGSFLPFTLNETTSIFFGPLTDEEKIELWDVCL
AFMGIVDTALLKG
PFRWGLGYWMLSREKYQSAKAYLARWEAFLMRTSQARKDQTDLPITR
LWRDVEVGNLSKDE (0)
LLQTLTESTVFNLEPTSHALIMTIFLISDNQAFQDNLVAELDANRSAITRYLGRKDTLL
HYALLEAVRLQPVL (1)
PFTLPEAASVDKGLGGYLIPKG (0)
TSVIADSYGINVRNPFWGPDATSYRPSRFTTLTPAEIHRNLSMFWFGARKCLGQFFA
KQVRAVVFNLFDRYKVTCSDYSGIAPGINVDKTEYVDRFGLEFLL*
CYP687A1 Aspergillus nidulans
AN9335.1 revised 7/18/07
47% to 223A1 Novosphingobium aromaticivorans bacteria
PROBABLE LATERAL GENE TRANSFER FROM BACTERIA
MEGVVTMTEARTQSNVSVSDFSLVTDN
NPEKIYAQFAELRSRCPVARTADNGGFYLLTRYEDIKNAASNTEIFISSV
KAVIPSDPRGIRRPPLNTDPPAHTPYRTALDRTLRPKRLRRLEPVLREHA
EREFAKLVAKGGGDICGDFAAIFAAWVETTWLNLEDGTAPMLANTAAAWV
NAWRRQDAKETSEQSEKLYLIARELFADRRVSPRDPEQDPASSLLQERDT
NGQPLKDELLIGALRQSLVVGMVAPPLLFGNICNHLSRDKELQNRLRSNP
SLIPAAIEEFVRLYVPYRGFCRTPSRDVELCGRTIPAKSPITMTYAAANR
DPSIFSQPDEFILHRPNITSHLGFGRGRHRCAGMPLARMALQIGLVVILQ
QSSDFEVNGPLQYAGMPEMGISSCPLRITPRDSVEPLRQT*
CYP687A2 Chaetomium globosum
XM_001226406.1 NZ_AAFU01001127.1
60% to 687A1
MAAAKTITCPFMATKLLSQERIDTSPAVISDNVDEILKEYDILR
EACPVAYTNQYGGYWLMTRYDDIKAAALDSDTFISSVRAVIPSDPRGLRRPPLNFDAP
NHTPYRTALDRTLKPARIKRLAEPLERHAEELLLPLLKKGEGDICTEFAAQFAAWVET
EWLNLARDTAPRLASTASAWVNAWRQRDGEKTTHFSTQLYDIARAVLADRRENPRDPE
EDPASSLLLERDSRGEPLEEIHLVGCIRQSLVVGMVAPPLMLGGICNHLSKNQELQQR
LRDDPTLIPAAIEEFVRLFSPYRGFARTVSKETVIHGQTIKPGIPITLTYSAANRDPA
VFDSPHEFILNRPNIAMHMGFGRGRHRCVGQPLAKL (2)
9538 ALQTALKTLLSKTTKFEVNGEMQFSRMPEMGIISCPLTFKIE* 9666
CYP687A3P Aspergillus flavus
Note first part is CYP687A like (65%),
Second part is CYP645A like (39%)
See fungal pages for seq
CYP687A3P Aspergillus oryzae
Supercontig 25: 1280400-1280807 (-) strand
51% to CYP687A3P Aspergillus flavus (best match in A. oryzae)
See fungal pages for seq
See Paramecium page for details on these sequences
CYP688A1 Paramecium tetrauralia
CYP689A1 Paramecium tetrauralia
CYP690A1 Paramecium tetrauralia
CYP690A2 Paramecium tetrauralia
CYP691A1 Paramecium tetrauralia
CYP691A2 Paramecium tetrauralia
CYP692A1 Paramecium tetrauralia
CYP692B1 Paramecium tetrauralia
CYP692B2P Paramecium tetrauralia
CYP693A1 Paramecium tetrauralia
CYP693A2 Paramecium tetrauralia
CYP694A1 Paramecium tetrauralia
CYP694B1 Paramecium tetrauralia
CYP694C1 Paramecium tetrauralia
CYP694C2 Paramecium tetrauralia
CYP694C3 Paramecium tetrauralia
CYP694C4 Paramecium tetrauralia
CYP694C5 Paramecium tetrauralia
CYP695A1 Paramecium tetrauralia
CYP696A1 Paramecium tetrauralia
CYP696B1 Paramecium tetrauralia
CYP696C1 Paramecium tetrauralia
CYP697A1 Heterobasidion annosum (white rot basidiomycete fungal pathogen of conifers)
AY827553
Magnus Karlsson
Submitted to nomenclature committee on April 23, 2004
38% to CYP64 sequences, in CYP64 clan of fungal P450s
CYP698A1 Penicillium paxilli
GenEMBL AF279808
Young,C., McMillan,L., Telfer,E. and Scott,B.
Molecular cloning and genetic analysis of an indole-diterpene gene
cluster from Penicillium paxilli
Mol. Microbiol. 39 (3), 754-764 (2001)
Gene name PaxQ
note TG boundary at intron 1 not AG
MDFVLSALQRDSWGIAAIILVSIWALHSFHRSRKLQ (0)
IPVPYVGKCGILGPWISALQWESKARELVQEGYEK ()
HGNFAFKVALLNRWEVCICNEDMIREYKNLMDNQFSAIAVTSE ()
LFQIKWTAPGTEEGAHKISIPLLGKALTWQRNRSAAQNDPYFSEFV
EEFLYAWKEEVPVPENGDYELPCFETGARVVAHLTARSLVGYPLCRNPEIVNLFTDYG
SAVPTSGFFIAMFPEIMKP
FVANFCSAPRISKRLQAILLEEFAKR
REEGGIEST ()
DIMGWLRNWTDQNEPGVYGDLEITSSIIATIFGAIHTTTQ ()
VLVHCLFELATRPEYVEPLRVEIQSA
LEEHGGWVKEGIEGMVKLDSFIKECQRFNPLDAG
SLARRATKDFTFKNGLTIPE ()
GTFVFAPNGPILFDDTLYPEARQFDGYRFYNLGQKTGKPQDFRFAATNQKYLQFGDGRH ()
TCPGRWMASDEIRLMLAHILMNYDIATKDNKGRPENWIFKKILFPDMKAVVILKARK
SVSA
CYP698A2 Aspergillus oryzae
GenEMBL BAE65190.1 AP007171.1
61% to CYP698A1 with some assembly errors
698A1 is from an indole-diterpene gene cluster
note the other P450 in this cluster is CYP653C2
The ortholog of 653C2/paxP (653C1) is 4 genes downstream of this gene
14 P450 genes and 2 pseudogenes on this contig
probable GC boundary after VTAE
frameshift after VETIL
1893711 MSRLLERTLDRFTGLLEYQPTYPFAAPTWVYLVGAILIQQLATRWYRYYKSW (0)
VNVPVVGGHGIIGSWIAAFWWTARARSLVNEGYQK (0)
HGDFAFQVSTPTRWEVFICNDEMVREYRNFTDERFSANAVTAE ()
LFEAKYTVPGAAEGVHKVPVPIVAKALTWQRTRAATKTDPYFEEFVKELQHAFDAETKFENED
WNDLCCFATGTRIVAHLTAKSLVGYPLSRDTELINLFAEYGNAVPTSGFFIAMFPQILKP (2)
FAAKFCSAPKISARLDRIVMDELRKREANPRSEPQ (0)
DITDWIMFWSRTYPGTYTDQDIARSVVSAVFGAIHTTTQ (0)
VLVHCLMDLAIRPEYIHPLREEVETIL
IGDNQQWTKEGLESMEKLDSFVKECQRFNPLDA (1)
GSLARRATKDFTFSKGLHIPE
GTFVFTPNSPVLFDEKHYPDAQQFDGYRFYRLGRVTGRPLEYKFIAANLKYLQFGDGRHIC (2)
PGRFMAADEIRLLLAHILVNYDIRPKDDGERPPNWTF
KKILFPDMKGMVQLKRRSINISQPN* 1891669
CYP698A2 Aspergillus flavus
AM921700
97% to CYP698A2 Aspergillus oryzae = ortholog
complement(join(11445..11634,11697..11940,11996..12176,
12236..12352,12397..12508,12562..12929,13003..13119,
13172..13276,13329..13484))
gene="atmQ"
function="aflatrem biosynthesis"
See fungal pages for seq
CYP698A2 Aspergillus flavus
98% to CYP698A2 Aspergillus oryzae
59% to CYP698A1
See fungal pages for seq
CYP698B1 Metarhizium anisopliae var. acridum Ma102
CYP698B1 Metarhizium anisopliae var. anisopliae Ma23
CYP699A1 Agaricus bisporus (mushroom)
GenEMBL AJ312129
Eastwood,D.C., Kingsnorth,C.S., Jones,H.E. and Burton,K.S.
Genes with increased transcript levels following harvest of the
sporophore of Agaricus bisporus have multiple physiological roles
Unpublished
cyp gene for cytochrome P450, exons 1-11.
MPILSLARDILFISLCGLIYRIFRNRRNRLLPLPPGLLRWPILG
NALSMPLTYAHIYYKHLGNKLGSKFIYLEAVGQPFLIINDYRVAKDLLEERSAIYSRP
QFPMSTEVIGLKRFFLLMPYGDIWRNHRRVFRQYFDPKYLPRDQEKQLNFIRKSLLPN
LFIAPEEAHEHVANCIGGFILSIVYGLPVKTRHDRLVRFAEKTFNDLAASTAPGKYLV
NIIPQLQYLPDWFPGTEFKRVALKTAEELDKLREEPYQAVLIAMVGHVVQNCLVSDNV
EKLRNAPDFEDRIVDVKEVARTIFGAGFETTTGVIMTFVLAMLLNNDVQLQAQSEIDA
VLGPERLPTFSDLSDLPYFSAVIKEVLRWNPIGPIGIPHATTNEDEYDGYYIPKDCIV
VSNIYAMLHDENIFPDPEKFDPGRFMKNGTTINDDLLNPIDVVFGFGRRVCPGSHLAM
SMLEITAASILCLFDILPALDAQGKPIDVVPEFTPASITSHPLPFKFNVSPRKGKDVE
GLLSEYMNVEYA
CYP699A2 Agaricus bisporus
partial mRNA for cytochrome P450 (cyp gene).
AJ271708
84% to 699A1, 42% to CYP502 Coprinus cinereus AB013443
ENVEKLCNAPDFDDRIAEVKEVARAVFAAGFESTTGNIMTFILA
MLKNHDVQRQAQSEIDSVLGIERLPTFSDLSDLPYFSAVIKEVLRWNPPVPIGVPHLT
TDEDVYDGYYIPKSCIVMSNIYAMLQDETVFPDPEKFDPGRFIKNGDMVNDELLNPKD
VIFGFGRRVCPGSHLAISMLEITAASILCLFDILPALDTQGKPIDVVPEFTPASITSH
PLPFKFTFSPRKGKDVEGLLSEFMNVEYA
CYP710C1 Trypanosoma cruzi (Chagas disease organism)
gnl|TIGR_5693|1047053506945
72% to Leishmania major seq
AA675972.1 AA556134.1, AA676046.1, AW330298.1, AA958228.1
AAHK01000113.1 34105..35622
XM_813889.1
note: not found yet in T. brucei, T. congolense or T. vivax
79% to CL844622.1 Leishmania donovani
37% to 710A1 Arab.
Member of the CYP61/CYP710 clan
Possible C-22 sterol desaturase
MTVISNVLGVQIPYLAEVAAIMLIAHGLAYLLTMFYFARKHKFS
IPGPKFVTPLLGGLVMMMKDPYTFWEKQRRYCPSGYSWLSILNQFTVFVTRADLCHKI
FATNSENTLTLQLHPNGRIILGDNNIAFQCGPRHKALRASFLNLFATKALSLYLPIQE
RLIREHLAEWVKKYPFEGKPEEMRGHIRELNCKTSQTVFVGEHLLDPEEFTRNYNIIT
VGFLSLPLYFPGTALYKAVQARKKVVDELKAAVIRSKARMSLPDAEAHCVLDFWSATI
LETLKACEDEGVDPPPFASDDAMAETLLDFLFASQDASTASLVMITATMADRPDVLER
VRQEQTKLCAGDEPLTFDLVQEMTFTRQCVLEQLRLFPPAPMVPMKAHSDFVIDGHYT
VPKGSLIIPSLVGACREGFPNPDVYDPDRMGSERQEDRKFAKQFIPFGVGPHRCVGYN
YAINHLTVYLALVARLAEWRRTRTPNSDKVIYLPTLYPHDCLCTWRHREGLKAGK*
CYP710C1 Leishmania major
LM30.1.Contig3 L. major Friedlin chromosome 30
this seq is 51% identical to Chlamydomonas CYP710B1
52% to Choanoflagellate P450 CYP710D1
78627 MAAFSRLLGVQLPYVMEVVIFLALAYATAYVLTNIMFASIHKFKMAGPLTAIPVLGGVVGMIRDPYSFWERQR 78845
78846 QYEPHGYSWMAILTQFVVFVTRADLCHKIFATNGEDTLTLQLHPNGKLILGDNNIAFQSG 79025
79026 PGHKALRSSFMNLFTTKALSLYLPIQERLIHEHLSRWVRDYPWGGKPEEMRTHIRELN 79199
79200 CETSQTVFLGEHLHNHTEFTHNYNIITRGFLSAPLYLPGTPLYKAVQARKLTM 79358
79359 VELQAAVRRSKARMAKPDAEPHCLLDFWTATVLEKIKEAEEEGGDAPAYSSDHAMADTIL 79538
79539 DFLFASQDASTASLTMITATMADHPEILERVRKEQARLRPNNEPLTYDLVQEMTFT 79706
79707 RQCVMEQLRLFPPAPMVPMKVHGDFQLDEKTVVRKGSMIIPSLVACCREGFTNPDTYD 79880
79881 PDRMGPERQEDRKFAKQFIPFGVGPHRCVGYNYAINHLTVYLALIAHHVEWQRTRTPD 80054
80055 SDKILYLPTLYPHDCLQTWRYREGIEPTAEKV* 80153
CYP710C1 Leishmania infantum
Contig2309 ortholog to CYP710C1 of L. major (10 aa diffs)
430 MAAFSRLLGVQLPYVVEVVIFLALAYATAYVLTSIMFARIHKFKMAGPLTAIPVLGGVVT 251
250 MIRDPYSFWERQRQYEPHGYSWMAILTQFVVFVTRADLCHKIFTTNGEDTLTLQLHPNGK 71
70 LILGDNNIAFQSGPGHKALRSSF 2 (amino acid 143)
141 aa gap
Contig3659 starting at amino acid 285
3 EEGGDAPAYSSDHAMADTILDFLFASQDASTASLTMITATMADHPEILERVRKEQARLRP 182
183 NNEPLTYELVQEMTFTRQCVMEQLRLFPPAPMVPMKVHSDFQLDEKTVVPKGSMIIPSLV 362
363 ACCREGFTNPDTYDPDRMGPERQEDRKFAKQFIPFGVGPHRCVGYNYAINHLTVYLALIA 542
543 HHVRWQRTRTPDSDKILYLPTLYPHDCLQTWRYREGMEPKAEKV 674
CYP710C1v1 Leishmania donovani
GenEMBL EF405865
93% identical to CYP710C1 of L. major
There is a second fragment from L. donovani named CYP710C1
but it is short. I don't think there are really two different
genes, so these may be alelles or the GSS seq could have errors
MAAFSRLLGVQLPYAVEVVIFLALAYATAYVLTSIMFARTHKFK
MAGPLTAIPVFGGVVTMIRDPYVFWERQRQYEPHGYSWMAILTQFVVFVTRADLCHKI
FTTNGEDTLTLQLHPNGKLILGDNSTAFQSGPGHKALRSSFMNLFTTKALSLYLPIQE
RLIHEHMSRWVRDFPWGGKPEEMRMHICELNCETSQTVFLGEHLHNRTEFTHNYNIIT
RGFLSAPLYLPGTSLYKAVQARKLTMVELQAAVRRSKARMTKPDTEPHCLLDFWTATV
LEKIEEAEEEGGDAPAYSSDHAMADTILDFLFASQAALTASMTMITATMADRPEILER
ARKEQARLRPNNEPLTYDLVQEMMFTRQCVMEQLRLFPPAPMVPMKVHSDFQLDEKTV
VPKGSMIIPSLLACCREGFTNPDTYDPDRMGPERQEDRKFAKQFIPFGVGPHRCVGYN
YAINHLTVYLALVAHHVDWQRTRTPDSDKILYLPTLYPHDCLHTWRYREGMEPKAEEKA
CYP710C1v2 Leishmania donovani
GenEMBL CL844622.1 (GSS section)
one aa diff to L. infantum CYP710C1
79% to CYP710B1 T. cruzi
9 amino acid differences to EF405865
3 SDHAMADTILDFLFASQDASTASLTMITATMADHPEILERVRKEQARLRPNNEPLTYEL 179
180 VQEMTFTRQCVMEQLRLFPPAPMVPMKVHSDFQLDEKTVVPXGSMIISSLVACCREGFTX 359
360 PDTXDPDRMGPERQEDRKFAKQFIPFGVGPHRCVG 464
466 YNYAINHLTV 495
CYP710D1 Monosiga ovata (choanoflagellate, single celled ancestor to animals)
GenEMBL CO435081, EC169877.1 EC166517.1 ESTs partial sequence
53% to XM_813889.1 Trypanosoma cruzi 710C1, 43% to 710A1
46% to 710A7, 56% to 710B1
note: seq ortholog not found in Monosiga brevicola at JGI
LGEHNIAFKHGPSHKALRKSFLNLFTRKALGVYLGIQERLVREHLATWKLVDEPTEFRLK
VRDLNLLTSQTVFIGPYLRSDEERVTFCNNYLLMTEGFLSFPIAFPGSGLWKAINARHAI
VDKLVAAARESKARMAAGADPECLLDFWSQRILEEIAEAKPGDEPAEHWSDWEMGNTMMD
FLFASQDASTASLTWTAAFMSERPDVLAKVQAEQKALRPNDEPLTYDMVEQLVYTRAVIK
EILRFRPPAVMVPAIAMVDFPLTD TCVAPKGSL
VVPSIWAACMQGFPHPEVFDPDRMGPERQEDVQYRDNFLTFGVGPHMCVGREYAINH
CYP710D2 Acanthamoeba castellanii
CW932844 GSS seq
56% to 710D1
KACSCARSHVDTSQSVFIGPYLSGDERKEFAKNYMMMNEGFLAFPLCIPGTALYRAVQAR
KKVVATLTTCAKLSKDRMSKGVEPECLLDFWMEKTVAEIQEAKAAGAPAPPHSSDHEVAC
TTLDFLFASQDASTASLVWTCGLALTGNPDVLAKVRAEQLKLRPNDDPLTTDVLGDMPYT
NQVVMELLRYRPPATLVPHIALKDFQLTDNVNVPEGSLVVPSVWGACHQGYTNPNTFDPD
RFSQERGEDRKYGKNFLTFGSGPHYCLGKQYAINHLMSFLSIMSINVDMNRHRTPESETI
VYGPTIFPADGVIADMKEKKYY*
CYP710E1 Euglena gracilis
GenEMBL EC680997.1, EC678269.1, EC667970.1
48% to 710B1 N-term part
MEWVAQASQRSTAGGKLSDIVLQILQGHPLKTAVACCCALVFWDQFKTWRVTRG
ITGPSWSWPFLGGLMHMVRDPYQFWERQKEWSRSKGLNISWNVLAGKLIFFVTDTAQIRH
VLHNNSPNDYVLKLHPSAEGILGKTNIAFMVGAEHKRLRSTFIELFTRKAMSVYVRAQDK
IIRKWLAEWSELKEPTEFRDLVRMANLQTSQLVFAEPYLGSEADREKFSEAYLDLT
EGFLGVPLWIPGTKVWKAR
See Tetrahymena page for details on these sequences
CYP5001A1 Tetrahymena thermophila
CYP5002A1 Tetrahymena thermophila
CYP5003A1 Tetrahymena thermophila
CYP5004A1 Tetrahymena thermophila
CYP5005A1 Tetrahymena thermophila
CYP5005A2 Tetrahymena thermophila
CYP5005A3 Tetrahymena thermophila
CYP5005A4 Tetrahymena thermophila
CYP5005A5P Tetrahymena thermophila
CYP5005A6 Tetrahymena thermophila
CYP5005A7P Tetrahymena thermophila
CYP5005A8 Tetrahymena thermophila
CYP5005A9 Tetrahymena thermophila
CYP5005A10 Tetrahymena thermophila
CYP5005A11P Tetrahymena thermophila
CYP5005A12P Tetrahymena thermophila
CYP5005A13P Tetrahymena thermophila
CYP5005A14 Tetrahymena thermophila
CYP5005A15 Tetrahymena thermophila
CYP5005A16 Tetrahymena thermophila
CYP5005A17 Tetrahymena thermophila
CYP5005A18 Tetrahymena thermophila
CYP5005A19 Tetrahymena thermophila
CYP5005A20 Tetrahymena thermophila
CYP5006A1 Tetrahymena thermophila
CYP5007A1 Tetrahymena thermophila
CYP5007B1 Tetrahymena thermophila
CYP5007C1 Tetrahymena thermophila
CYP5008A1 Tetrahymena thermophila
CYP5008A2 Tetrahymena thermophila
CYP5009A1 Tetrahymena thermophila
CYP5010A1 Tetrahymena thermophila
CYP5010A2 Tetrahymena thermophila
CYP5010A3 Tetrahymena thermophila
CYP5010A4 Tetrahymena thermophila
CYP5010A5 Tetrahymena thermophila
CYP5010B1 Tetrahymena thermophila
CYP5010C1 Tetrahymena thermophila
CYP5010C2 Tetrahymena thermophila
CYP5011A1 Tetrahymena thermophila
CYP5012A1 Tetrahymena thermophila
CYP5012A2 Tetrahymena thermophila
CYP5013A1 Tetrahymena thermophila
CYP5013B1 Tetrahymena thermophila
CYP5013C1 Tetrahymena thermophila
CYP5013C2 Tetrahymena thermophila
CYP5013D1 Tetrahymena thermophila
CYP5013E1 Tetrahymena thermophila
See the stramenopiles pages for these sequences
CYP5014A1 Phytophthora sojae
CYP5014B1 Phytophthora ramorum
CYP5014B1 Phytophthora sojae
CYP5014C1 Phytophthora ramorum
CYP5014C1 Phytophthora sojae
CYP5014D1 Phytophthora ramorum
CYP5014D1 Phytophthora sojae
CYP5014D2 Phytophthora ramorum
CYP5014D2 Phytophthora sojae
CYP5014D3 Phytophthora ramorum
CYP5014D3 Phytophthora sojae
CYP5014E1 Phytophthora ramorum
CYP5014E2 Phytophthora sojae
CYP5014E3P Phytophthora sojae
CYP5014F1 Phytophthora ramorum
CYP5014F1 Phytophthora sojae
CYP5014F2 Phytophthora ramorum
CYP5014F2 Phytophthora sojae
CYP5014G1 Phytophthora ramorum
CYP5014G1 Phytophthora sojae
CYP5014H1 Phytophthora ramorum
CYP5014H1 Phytophthora sojae
CYP5014J1 Phytophthora sojae
CYP5014K1 Phytophthora ramorum
CYP5014K1 Phytophthora sojae
CYP5014_un1 Phytophthora sojae
CYP5014_un2 Phytophthora sojae
CYP5014_un3 Phytophthora sojae
CYP5015A1 Phytophthora ramorum
CYP5015A1 Phytophthora sojae
CYP5015B1 Phytophthora ramorum
CYP5015B1 Phytophthora sojae
CYP5015C1 Phytophthora ramorum
CYP5015C1 Phytophthora sojae
CYP5015C2P Phytophthora sojae
CYP5015D1 Phytophthora ramorum
CYP5015D1 Phytophthora sojae
CYP5015E1 Phytophthora ramorum
CYP5015E2 Phytophthora ramorum
CYP5015E3 Phytophthora ramorum
CYP5015E4 Phytophthora sojae
CYP5015E5P Phytophthora sojae
CYP5015E6 Phytophthora sojae
CYP5015E7 Phytophthora sojae
CYP5015F1 Phytophthora ramorum
CYP5015F1 Phytophthora sojae
CYP5015F2 Phytophthora ramorum
CYP5015F2 Phytophthora sojae
CYP5015G1 Phytophthora ramorum
CYP5015G1 Phytophthora sojae
CYP5015G2 Phytophthora ramorum
CYP5015G2 Phytophthora sojae
CYP5015G3 Phytophthora sojae
CYP5015G4 Phytophthora sojae
CYP5015G5 Phytophthora sojae
CYP5015G6 Phytophthora sojae
CYP5015G7P Phytophthora sojae
CYP5015G8P Phytophthora ramorum
CYP5015G9P Phytophthora ramorum
CYP5016A1 Phytophthora ramorum
CYP5016A1 Phytophthora sojae
CYP5017A1 Phytophthora ramorum
CYP5017A2 Phytophthora sojae
CYP5017A3 Phytophthora sojae
CYP5018A1 Thalassiosira pseudonana
CYP5019A1 Thalassiosira pseudonana
CYP5020A1 Thalassiosira pseudonana
CYP5021A1 Thalassiosira pseudonana
CYP5022A1 Thalassiosira pseudonana
CYP5023A1 Thalassiosira pseudonana
CYP5024A1 Thalassiosira pseudonana
Please see the Ustilago maydis page for these sequences and five more
CYP5025A1 Ustilago maydis
GenEMBL XM_404078.1
in the CYP52 clan 39% to 557A1
See fungal pages for seq
CYP5025A2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.3.736.1
59% to CYP5025A1 Ustilago maydis
See fungal pages for seq
CYP5025B1 Ustilago maydis
GenEMBL XM_404088.1
in the CYP52 clan 38% to 557A1 if some inserts removed, 42% to 557B1
See fungal pages for seq
CYP5026A1 Ustilago maydis
GenEMBL XM_399338.1
in the CYP52 clan 45% to CYP5026B1 36% to 557A1
See fungal pages for seq
CYP5026B1 Ustilago maydis
GenEMBL XM_399478.1
in the CYP52 clan 45% to CYP5026A1
See fungal pages for seq
CYP5027A1 Ustilago maydis
GenEMBL XM_401724.1
37% to 530A1 with some insertions deleted
in the CYP64 clan clusters with CYP664, CYP665, CYP530 and CYP619
See fungal pages for seq
CYP5027B1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B2v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B2v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027B3v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B3v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027B4v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B4v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027B5P Postia placenta (brown rot basidiomycete fungi)
CYP5027B6v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B6v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027B6v3 Postia placenta (brown rot basidiomycete fungi)
CYP5027B7v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B7v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027B8v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B8v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027B9v1 Postia placenta (brown rot basidiomycete fungi)
CYP5027B9v2 Postia placenta (brown rot basidiomycete fungi)
CYP5027C1 Postia placenta (brown rot basidiomycete fungi)
CYP5028A1 Ustilago maydis
GenEMBL XM_399810.1
37% to 532D1 in the CYP53 clan part B
MTTAPHTGIVESSVVATLAKILLTPLSGWPSMLQLLTGSFVLLFGWIVYNLAISPLSRYPGPLSARLGIPFWRFWHSLQGDYAPALYSLHRKHGDVVRIGPTHLSFADPTAMNSIYSLSDGVSSKFRKSNFYRSFQVFKAHPSIFSERDPHQHSKRRRAVASAYSMNSLVKLEEYVEDVTELLLKRLDELVETNSVVEGGGTSEKTKTKAVRLDPWFHYFAMDVVGELAFGQSFNLLHRGKDDERFLTGVLNLSQWGAVAGCMPLLSSLILWLFPRITGQPGGSVIGDKTTSRIQTRYAEVQDNGGVASRPDMLTKFMEARDPDTKEKYSMKQVLFSASSVMSAGSDTTATSLTIFFGYLLEHPACYAKLRQEINEAIQAGHLISPVKYAKGAQLEYLQACIKEALRLSPPISMDLPRYVPAGGALIGKNPHVIPAGTTVGISPYVLHRQPEAFGADAEMFRPERWLEGGEEGRKAMERFNMTFGGGSRACIGKNISLMELSKTIPEILLRYDIKKPAVSTHLHTTPSNAKQPFFQGKSAWFLEAHVSHHRFHNFE
CYP5029A1 Ustilago maydis
GenEMBL XM_403406.1
38% to 65M1 C-term in the 53 clan part A
clusters with CYP671, CYP628, CYP670 on trees
See fungal pages for seq
CYP5030A1 Ustilago maydis
GenEMBL XM_404074.1
43% to 576A1 C-term in the CYP53 clan
clusters with 576A1 on trees
MAKLSRLDPCSRIAVYVERTHGLLLEVQQPSNTKRLDLLASLNPHLNAPPSAAKMLNETIFGRQVADVREHGLFGRPFWLNALYAFLLYSAFLGYKSYFLHKTSRIPGPWHLHWTMLPALFYYVRGTQWRYVDKLHEKYGPLFRLGSRQIYVSDKDAIRQLLAKENLPKVNWYASLSRDPKTAGMFTTVNKEYHRSRRRLMSPAFAVEFTRQLEPFLVDATTKLFEGYHQRVQKASDPFKPLLFNVYEDLACLAMDILGETAFGVSFNLVACRDDPGADRKFADINKLLAKYLHDGGIRFFCRPFDKYMKRDLNVYKLTNPLVDARFAETEARRAAAGDAAEQVETREDILQYLVDASLEMQKGQKEKLTRTHVRDQCVELLIAGGETTSNTITYILKALLENPAKLAKLYETIEPEPLDDAVPGFTQLPETPYLDACIQEGMRMYPVTSELGRRTGKEPTVVLGHVIPPRTAISASLRALHYSPKYWASPNRYWPERFLPADSIHSASDPAPAADMEAFMPFGCGPRNCIGSKFAWHEMRMVLHTLLARYTISAVEATDKVDFRQFVTFQLAKPEYRIAVTPRMALKA
CYP5031A1 Ustilago maydis
GenEMBL XM_401804.1
clusters in the 56/547 clan
with CYP616, CYP617, CYP618, CYP582, CYP547
See fungal pages for seq
CYP5032A1 Ustilago maydis
GenEMBL XM_403279.1
clusters in the 56/547 clan
with CYP616, CYP617, CYP618, CYP582, CYP547
See fungal pages for seq
CYP5033A1 Ustilago maydis
GenEMBL XM_399595.1
36% to CYP5034A1 37% to white rot Scaffold_7 C-term (not named)
MAISTSSRLVIHQDVLSWLQHRPFASAFTLLVVYITYKLAIKPILFPSPYRHLPRPERASYILGQRI
VEANGLTYIDASTNQRVKVSGPGEVCKHYARTLDTSVFVFPEPFGGETLFISDPFALNAILADVDKF
QSDLLRTTIIEFIVGKGIVARFGDAHRKQRKLMAPAFTPAHIKGLTPIFAKYAQLMCHKIALADDES
VDFAEYLDCTMLDIIGEAGFGYRCSALERGRGGSELSSAFNSVNQAAIDFGPARAIHLGLSAMLYPR
ASIWPLSEANRRIAKVNRVMDRITMQIVREAKSRVEKEGEDLGDKKDLLSLLIKSNLDARIGERMTD
KEISGQIQTFMFAGYETSSVTTSWTLYFLARHPEVQNKLRNILTATLSERKGIPLEELDVSTLEYDD
VWCQDLEYFDWILAETLRLCPPLSGNDRQAMQDSVLPLMTPVKMTNGENVSQLMVKKGSRLTIGIKT
VNCDRKLFGDDADEFRPERFAELPQRHAEAKLPPYATYSFFGGPKSCIGSKFALTEMKVIIIAVLSR
FQLSPEP GVTIKQHQALIVRPRVETSTGGPAAGMPLRIKRLPHQVSV
CYP5034A1 Ustilago maydis
GenEMBL XM_397817.1
36% to CYP5033A1
See fungal pages for seq
CYP5035A1 Phanerochaete chrysosporium (white rot fungus)
AY866400.1
Jagjit Yadav
Submitted to nomenclature committee July 15, 2005
Clone name PFF-9, JGI gene model pc.12.112.1
Also called PC-hn-2
Same as scaffold_9 in the whiterot sequence files
60% to CYP5035A2, 58% to CYP5035A4
MADTSLLSRRLKSFFDPQGSPTLLSLPDSFVHLIFKRWEPMKLPIVAFLLFLVPACLSLL
FASHLSLTKGLATAFATFYTVLVSSIVIYRISPFHPLARYPGPLAAKITKWWHAYHVHTG
KQHLYVRRLHDQYGDIVRIGPNDVSIRDASCISSGLGSQGLPKGPMWDGRFMYSPIPAMV
GARDHAYHMQRRRPWNRAFSATALKEYEPLIYGRVHQLVSALADRQGQVVDIAKWIGYFT
YDFMGDMVYGGWTEMLRDGKDEDGLWDVVHRGLEDVSAVYGEVPWVSYYASMLPNVGKDL
KRMRKMAFDRAKQRYDSGSKARDLFYYLSNEDGAEKVTPPRPIVVSDGVLALIAGSDTTA
IVTATILYSLLCNPTTYHRLQQEVDKFYPRGEDPLNPKHYKDMHYLEATINEGLRLFPAT
PSGTQRAPAPGKGDRLIGKYYIPEGTATKFHFWSIQRDPRNFSHPDTFWPERWLVAEGLE
HADEPLTHNANAFVPFSFGPYNCVGKNVAMQEMRMLLCHLMHTLDLRFPEGYVPRAFEDA
LEDQFGFKVGELPVIVQRRE
CYP5035A2 Phanerochaete chrysosporium (white rot fungus)
No accession number
Same as scaffold_69a in the whiterot sequence files
JGI gene model ug.97.52.1
60% to CYP5035A1
MGSDAQLPVLSPRDAFAIIVLSAVGAHLVFKRWEPKKLRVVTFLLFLVPACLSTLLLPHF
GTALGLTVGFLTYWTALTLSIVFYRVGPLHPLYQYPGPLPAKISKWWHVWHVQQGKQHLY
LQQLHDKYGDIVRIGPNEVSIRDPACITPVLGAQGMPKSDMFLGRNMWPETAPLIGYRDP
AEHMKRRKPWNRAFSSASVKEFEPIIQHRVHQLVEALSDRQGQVVDLAEWISFFTYDFMG
DMVFGGWTEMMRDGADKGGLWDLLRRGLTVSALWGEVPWVSYYAKKLPWTAQDNKAMRVM
AFSRTEQRYASGSASKDLFYYLSNEDGSEKVSPPRNIVIGDGLLALVAGSDTTATVVANT
MYELLRHPAAYRRLQEEVDKFYPRGEDSLDPKHIKDMHYLEAVINEGLRMYPAVPSGSVR
APEVGKGGKIAGPYYIPEGTQTRIHFWSVQRDARNFSFPETFWPERWLIAEGIEPAPAGE
KLVHNPNAFTPFSFGPYNCVGKNIALAEMKQLLCHLVHKLDVRFADGVDPDAFDRASEDR
FIYVVGELPVVVERRD
CYP5035A3 Phanerochaete chrysosporium (white rot fungus)
No accession number
Same as scaffold_249a in the whiterot sequence files
JGI gene model ug.53.54.1
56% to CYP5035A1
MAGDLSTRDALGIIVVSALGTHAIFKRWEIKHILVVSTLLLFLPAALSTLLIPHLGSFKG
IAAGFSVYFITLLSSITLYRISPFHPLAHYPGPLLPKISKIYHIAKVSSGKQHLYLQELH
NQYGDIVRFGPNEVSIRDASCIMPVLGAQGMPKGPMWQGRHFWTEVHTLIGFRDPKAHQR
RRRPWNRAFNTAAMKEYTPLMQNRVRELGDALVARQGQVVDLAEWIGFFTYDFMGDMVFG
GWTNMVREGGDRERLWEVVKSGLKIEFIYDNIPWLSYYTRNIPGAGNAELRAMAIGQTEK
RYSRTSTSKDLFYYLANGAEKEDPPKHTVVVDGGLALVAGSDTTSSVLSSIFYCLLRHPD
TYDRLQAEVDKFYPPGEDSLDPSHLSDMNYLEAVISEGLRLFPAVPSGSQRAPEIGTGGK
LVGPYYIPEGTQTRIHFWSVHRDPRYFSRPEAFWPDRWLIAEGLQAHAAGDEPFVHNPNA
WTPFSFGPSNCVGKNLALQEMRMVLVHLMHRLIVRLADGWDPAQYEREMEDRFVFSIGRL
PVVVERRD
CYP5035A4 Phanerochaete chrysosporium (white rot fungus)
JGI gene model ug.53.86.1
Same as scaffold_249b in the whiterot sequence files
58% to CYP5035A1
MAAREAILIIALFAVVSTISHVIFRQWEVMHCSVVLGLLVVIPAVLSTPLVSDFGIPCGL
ALGFTTYFAVLLLSITLYRISPFHPIARYPGPLLAKISKIYHVSKIWSGKQHLYLQRLHE
KYGDIVRIGPNELSIRDVSCITPALGAQGMPKGPMFNGRHLWPETHSLIGFRDPKEHQRR
RRPWNRAFNTASVKEFNPIIQARVQELGDAFAAREGQVVDLAEWIGFFTYDFMGDMVFGG
WTHMVREGADHNGLWQLIKSGMKVSFVYEHIPWLSYYVKKLPGAGSDLKMMRAMAFGQTE
KRYATTTTTRDLFYYLTNEDGSEKVDPPKAVVISDGALALIAGSDTTSTVLTSTFYCLLR
NPETYKRLQEEVDMFYPAGEGSLDPKHLPEMHYLEAGLRLFPAVPSGTQRAPEVGKGGKA
IGPYYIPEGTQTRLHFWSIHRDPRNFSHPEMFWPDRWLIAEGLQECVGEKLVHNPNAWLP
FSFGPSNCVGKNLAMQEMRMLVCHLVQRFNFRFADGYDPAQYERDWQDRFVVMIGQLPVTIERRA
CYP5035A5 Phanerochaete chrysosporium (white rot fungus)
JGI gene model pc.1.6.1
Same as scaffold_141 in the whiterot sequence files
57% to CYP5035A1
MPSGILGQLQSLPAKLTAQDATLVAHVIFKIWEPMQARIVSLLVIIAPLLLSTLFIPHYG
TVSGVFRSFAIYLTTLVSSIVVYRLSPWHPLARYPGPLLAKVTKLYHALMVSKGKQHVYI
KALHDQYGDIVRIGPNEVSIRDAACIQPLMGAQGLAKGPSWSGRSMFPPISPLIGIRDPA
EHARRRRPWNRAFNTNGIKEFMPTIQTRVQQLAEHLGERHGQALDLAEWFSFFTYDFMGD
MIFGGWTEMMRDGGDLQGLWTRVKAGLQHAGMVPEHVPWVAYYAKKIPSVVRKVSEMRGM
GISRAKMRYQQGSTSKDLFYYLSNEDGSEKVTPPPEVVTSDGALALVAGSDTTSSVLSNL
FYCLLRDPVSYKRLQEEVDKFYPPGENSLDPRHINNMPFLEAVINEAMRLYPVVPSGSQR
SPEIGKGGRAVGPYYIPEGNQARVHFWSVFRDSRNFSHPETFWPDRWLIAEGLQESPEKI
THNANAFVPFSFGPANCVGKNLAIQEMRLAVTHLMHKLNFRFADGFNPDEWDSQIQDVTV
MQLGKLMVVVERRD
CYP5035A6 Phanerochaete chrysosporium (white rot fungus)
JGI gene models pc.42.19.1 and genewise.42.13.1
HLIYKRWEPLRLSVTLTLLMGVPAALSVLLIPHLGLLRGALATFSLYLSTLISSIVAYRL
SPWHPLARYPGPLPARVTQLWHTWQAHKGQQHLYLKQMHDKYGDVVRMGPNEISIRDADC
IVPLYGPHGLPKGPSAGRQMHPQELSLIGYRDPARHSVRRKPWARGLGTAAVREYMPALR
SRVSQLVDALGARSGHPVDLAEWIAFFAYVFVSDCSLSXLANCQSGMTLWATWRECHGAG
AVFEQVPWLAYYAKMLPAISQRILKMRKLTVRHATRRYNSGSFSRDLFHYLSGEDLPEGS
ARPPQHIVAADGLLAVVAGSDTTASALSNLFYCIMRHRDVYKRLQQEVDQFSPLGDDSLD
PQHLNNMPYLNAVINETLRYLPSVLSGSQRAPLIGGGGVSVGPYYVPEGNQVRVHFYSVH
RDPRYFSDPDRFWPERWLIADDRQPSSEKIVHDDRAFIPFSYGPSNCVGKGLALQQMKST
VCHVMAKLEMRFADGYDPDTWEEQVQDEGVMIV
CYP5035A7 Phanerochaete chrysosporium (white rot fungus)
JGI gene models gw.54.12.1 and genewise.54.12.1
KSVHLIFKRYEPMHILVVSTLLLLLPAILTVPLIDQLGIAKGFLVAFATYFATLLSSITL
YRISPFHPLARYPGPIIAKVSKIYHVAQVWSGKQHLYLQRLHDRYGDIVRFGGFSTCSLR
GPNEVSIRDVSCIAPMLGTQGMPKGPGKHCWPEIHTLIGCSDIKEHQRRRRPWNRAFSTA
AMKEYNPIIQKRLQELGDALAARQGEVVNLADWISFFTHVPWLSYYTRNIPGATNDEFRG
MVFGQTVKRYACTGTTKDLFYYLNEDGAEKEDPPKPIVVVDGAVALIAGSDTTSTVLAST
FYCLLRNADTYKRLQAEVDRFYPPGADSLAPDHLPEMHYLEAEALRLFPAVPSGSQRTPE
RGSGGKTIGPSYIPEGTQTRIHFWSVHRDPRNFSRPETFWPDRWLIADGLQKDEGVEFVH
NPNAWIPFSLGPANCVGKNLALQEMRMVLVHLLHRFSFRFAGDYNPEQYEWDIEDRFVVA
VGRLPVIVERR
CYP5035B1 Phanerochaete chrysosporium (white rot fungus)
No accession number
Same as scaffold_247a in the whiterot sequence files
84% to CYP5035B2
MGTEYVLPLLRTNILKLPTNMTRNDALLAVGGAAV
LCHLIFKKWEPTYIPAVVTLLLVVPLGLSALLVPHYGQLLAPLVALATYHTILLTSIALY
RLSPWHPLAQYPGPLPAKLSKWWMVWQERDCKQHLYIKQLHDRYGDIVRIGPNELSIRNV
DAVAPLMGTNGLPKGPS
LRGQGLEPPITGLIAIRDPAEHARRRRPWTRAFSTA
ALKEYEPILVKRISQLCEQLASQKGTLDLATWFSWFTYDFMGDMV
RFGGGSEMLAHGDQDGIWTMFKEGGE
GQMMYHHIPWLAHYAKRLPMSPALKKMRGFALGRTAERYKKGASTKDLFYYL
SNEDGVEKTPPPAAQVISDGVLATIAASDTTSTTLSNAFWNILRHPHYY
KRLQAEVDKFYPVGENAFDTKHHSKMTFLDAVL
NETLRMYPVLPSGSQRAPFPGNGDRVVGP
YYIPDGTQARIHFWSLQRDPRYFSHPDTFWPERWLIAEGLEPAPAGEKFVHNPNAFIPFS
FGPSNCVGKNLAQMEMRMVFCYLLQNLDFELDKSWNPAERENATEDQFVLLMRSPVQVTVRRRV*
CYP5035B2 Phanerochaete chrysosporium (white rot fungus)
JGI gene model pc.54.66.1
Same as scaffold_144 in the whiterot sequence files
84% to CYP5035B1
MGSEVAMQLLRANISKPFPRLDQNDALAVVVGAALVVCHLIFKHLEPTYIPAVLFLLVLV
PLYLSALLLPHFGPLLAPVIAFTTYHTSLLTSIGLYRISPWHPLAKYPGPLPAKLSKWWM
VWKERDCKQHFYLEDLHKRYGDVVRIGPNELSICNVDAVLPLMGPDGLTKGPCSTIGQGL
EQPIPSLVSIRDPAEHARRRRPWTRAFSTAALKEYEPILAKRISELCEQLAQQKGSLNLA
TWISWFTYDVMGDLVFGGGNEMLATGDQDGIWAMFEKSGEGQMVYHHVPWLAHYAKRLPM
SPALKKMREFALGRALERYKRGAVTKDLFYYLSNEDGSEKIPPPPAQVIGDGVLATVAAS
DTTSTTIANTFWHILRYPHYYKRVQAEVDKYYPPGESAFDTKHHNKMTFLEAVIHETLRL
YPVLPSGSQRSPVPGKGDRVVGPYYLPDGTQARVHTWSLHRDPRYFSRPDTFWPERWLIA
EGLEPAPAGEPFVHNANAFIPFSFGPANCVGKNLAYLEMRMVFCHLLQNLDFELDKRWNP
AERSRSAEDQFVLYMRCPLPVTVRRRV
CYP5035B3 Phanerochaete chrysosporium (white rot fungus)
JGI gene model pc.92.54.1
PFF_271
MGAGYVPQLPRSYALTSFTGTSQTHALTPVIGAALITHLNFKRWEPLNLPIVIFLPLVAP
LGLSALFAPGPSYGSLVAPFITLFLYHAILLASIALYRISPWHDLYHYPGPLPAKPSKWW
MVWKERHGKQHLYVKALHDRYGDVVRTGPNEISIRDVAAVVPLMGTKGLPKGTAPWGEPI
VPSVVPLIGIRDSVEHARLRRSWARAFTAGALKGYEPVLTARITQLIAKLGSQTGEXIDL
ALVLSYFSYDFMGDMLYYGGGSELLAEGDNDGVWALGQMTCHHLPWLAKYKDLLPASPGL
QKMRSVALQRTMARYKNGGLGKDLFYHLSNEDSAEKTSPPTEQLVSDGVLAVFTASDTIA
TVLSNVFWSILRFPRYYEQLQAEVDKFYPARADAFDTAHYGEMVWLDAITNEALRLYPIV
PSGSQRAPAPGDGARVVGPYVIPAGTNARVHTWSLQRDPRCFSRPDAFWPERWLAAAGLG
DSEATCEGPEGAAGAAEDFVHDARAFEPYFVGPLDCIGRALAQLELRMVLCALLQRLAFA
PARGDPLERERTLQDQFVVMMRGPVMVSVSWRA
CYP5035C1 Phanerochaete chrysosporium (white rot fungus)
JGI gene model ug.43.44.1
MSAVLNSLSPTESVLAVVTCALATHLVFNRFEPTELPVVAAALVGLPAVLSALLVGHFGL
LAGAALAFATFHATLAASIVLYRLSPFHPLARYPGPLPARITRWYWARVACGGRQHLELK
RLHDVYGDIVRIGPNELSFRDISVVQPMMGAQGMPKGPMWDGRTFKPPILPLVGMRDVAD
HTRRRRPWIRAFTPAALKEYEPVVAKRGAQLIEILAQKKHTDFVHWIHLFTFDIMSDALF
GGNPGAEMMSHEDKDGIMHSMKTGFEAGQLFEHIPWLGYWMRHFPQLATATKQYRAMCFQ
RGMQRYQDGSSQKDLFYYLVNEDGAEKQTPDKATVIADSALAIIAGSDTTASVFSNMVYC
LLKNPHAYKRLRAEVDEFYPPEENSLDPKHHSKMPYLEAVINETLRLYPVVPSGSQRAPE
LGTGGTLMGTHYIPENTSVRVHFWSVHRDPRNFSQPESFLPERWLAAEGLEAPPAGLSGA
PQDADSAAARGTFVHNANAYMPFSFGPWNCVGKALALLELRCVATHMMQRLDVRFADGWD
PAEWDAAMEDKFVIKTGRLPVVVERRF
CYP5035D1 Phanerochaete chrysosporium (white rot fungus)
JGI gene model ug.50.50.1
MITVNRPSTQDSVIATVACAIIVYFVCKRWEPWRLAVVVPLTMLPPLVLSLPLAASVGFL
NAVITTSSTFASALVAMLTFYRLSPLHPLSQFPGPLQCKISGFWMAWIVSRGKRHVYIQS
LHEKYGDYVRIGPNEVSINDPTAIPQILGSYGWPKASGMSGRALHQDPLPLISLLDDAEH
SRRRKSWNRAFSSAAVREYQPVVAQRATQLVQALQEQRSVVDLSQWMRLPSDIAFVNLHD
FLYSFGGGTEMLREGDKAGLWQLLKDGMSTAVPFEHVPWLSHYILHFPALIRSLTDLRAL
AFGRSKLRYERGSTTKDLFYYLVNEDHADAEMPPMKVVISDAVLAIVAGSDTTAVTLSNI
FYYLISHPDTYRRLQEEVDKYYPPGEDALNPKHYVKMSYLDAVLNEAMRLYPALPSGSMR
TPAKGSGGQVVGQRFIPEGTQVRVHPYTIQRDPRNFSYPNRFWAERWMIASGNQSHHEKI
AHNPDALIPFSTGPRNCVGKNLALLEMKMVTCHVTQRLSLCFADGWDPSRWWDDLEDVFV
SRMGQLPVIVRSR
CYP5035E1 Phanerochaete chrysosporium (white rot fungus)
JGI gene models pc.97.5.1 and genewise.97.3.1
MQAAHLVFNRWEPTNIAVVAALLLGVPCAAASLLFSGRGFVPRLALTAALYYACLGTSVV
LYRLSPWHPLARYPGPWLLKTSKLWMVRRVKRGGQWRYIRELHQRFGDVVRIGGPNELSF
CDAAMVVPVLGTQGLPKGPGLIALRDPLEHQRRRRTWNRAFKPAALQEYLPLIQKRTAQL
LDALSKCEEQDVVDLGRWIRFCKYAHMPWLAQFTKHIPRVAAKLKELRAAARSRAAARYK
AGANRKDLFYYLVGDSNEDGGEKEQPTEDVILSDALLAIIAGSDTTSTILTSAVYCLLTH
PDVHKRLVEEVDKFYPPGADWCNTEHHADMHYLNANETLRLFPVLRDGSLRAPWVGHGDR
ALGPSSFIPEGTQVRVHTYSLQRDPRCFSQPDTFWPERWLVAGGLQHAEPGFVHEPGAFL
PFSRGPSDCVGKGLALQDMRIVLCALLQHLELAPPRNRPFDEWKAEVDRRFADSSAVLPV
SVRVRRRV
CYP5035F1 Postia placenta (brown rot basidiomycete fungi)
CYP5035F2 Postia placenta (brown rot basidiomycete fungi)
CYP5035F3v1 Postia placenta (brown rot basidiomycete fungi)
CYP5035F3v2 Postia placenta (brown rot basidiomycete fungi)
CYP5035G1 confidential basidiomycete
CYP5035H1 confidential basidiomycete
CYP5035J1 confidential basidiomycete
CYP5035J2 confidential basidiomycete
CYP5035K1 confidential basidiomycete
CYP5035L1 confidential basidiomycete
CYP5035L2 confidential basidiomycete
CYP5035M1 confidential basidiomycete
CYP5035M2 confidential basidiomycete
CYP5035N1 confidential basidiomycete
CYP5035P1 confidential basidiomycete
CYP5035Q1 confidential basidiomycete
CYP5035Q2P confidential basidiomycete
CYP5035R1 confidential basidiomycete
CYP5035S1 confidential basidiomycete
CYP5035T1 confidential basidiomycete
CYP5035U1 confidential basidiomycete
CYP5036A1 Phanerochaete chrysosporium (white rot fungus)
JGI gene model pc.15.127.1
Jagjit Yadav
Submitted to nomenclature committee July 15, 2005
Clone name PFF-57, PC-hn-1
Same as scaffold_57 in the whiterot sequence files
68% to CYP5036A2, 58% to CYP5036A3
MDALDPRIAIPIVYFIYKKYEPSSPRSAFFLLLALPGVLAVALRVCERFNSYATAVPTVY
LAYWSLLSTFVVAYRISPFHPLARYPGPLLCKISKGWLAYVAGKGGKAHLYVQDLHMRYG
EVVRIGPNELSITHQDFTRVVLGAKGLPRGPYYDSRQHEAGMSLDGMRDQALHAIRRRPW
ARGMNTAAMKYYEELIRNTLSDLIAGLKQRTNRPVDISEWTNYFGFDFMGQMAFTRDYGM
LKNGYDKEGLLDLIEHAMQDSAWISHITWSIPFLRYVPGASKYWDQMKAVGERAVADRVA
LGSNHRDLFHYLMDEDGHEAVRPTKALVAVDGQLAIIAGGDTTATTLSHIVYFLLRYPIY
LDRLRKEIDETFPDGADSTLDFTKQTNMPFLNACINEALRLYPPVLAGLQRRVEPGTGGK
MIGPYFVPEETQVSLFAYSIHRDPQHFSPLTNTFWPDRWLSQEKYTLPSGDVISADEVVT
NRDVFIPFSQGPMVCAGKNVALTEMRSVMCALLQHFDLKIADQSFLDSWEDKIEETFTTK
RGTLPVILSLRA
CYP5036A2 Phanerochaete chrysosporium (white rot fungus)
JGI gene model ug.170.56.1
Same as scaffold_284 in the whiterot sequence files
68% to CYP5036A1
MFFPLDSWVAVPVTSAVTYFIYKTLEPSSPVSVLLLLGIAPGALSWTLYGGSGSVIAHIF
TVYVSYWALLVTYTIAYRLSPFHPLARYPGPLLCRISKAWLAYIVATSGKMHLYIQNLHM
RYGDVVRIGPNEVSVTHRDFIGVIGPKGLPKGPYYETRAHKAGTSLNAIRDQALHSVRRR
PWARGMNSAAMKYYEELVEETVGDLVASLKRRTTKAIDFSEWMTYFGFDFMGHMAFTHDY
GLLKNGYDKEGLTPLIEHAMQDVAWVSHVPWSIDYLRHIPGVYKHWLRIKALGVQTVRKR
IALGSTRRDLFYHLMDEDNRERVKPDINVVAIDGQLAIIAGGDTTATALSHLFYCLLRHP
QYLERLRKEIDDAVPIACGSFKLDFSKLPAMPFLNAFINETLRLYPPVLSGLQRRVEAGT
GGRFIGPHFIPEQTQVSFSAYTIHRDPRYFSPLTDTFWPDRWLVQEQYVLPSGGVIPAAE
VVTDRDVFFPFSQGPTVCAGKTLALTEIRSVACALLQTFDISNADEASFDAWEDNLEEMF
TTKRSTLPVFLSLRT
CYP5036A3 Phanerochaete chrysosporium (white rot fungus)
JGI gene model ug.128.46.1
Same as scaffold_78 in the whiterot sequence files
58% to CYP5036A1
MSAIFAASSTTYIIFKRFEYSKPVPALVLLIGVPMTLASVLRDHFAGLATAMCATAAVHW
VLLTLFVAAYRISPFHPLARYPGPLPCKLSKCWMAYLAGSGGKTHVYIDRLHRLYGDVVR
IGPNELSVRHKDACTTVLGAKGLPRGPYYDTREHDNGVSLDGIRDPALHAVRRRPWARAM
NSASTQYFEELIQHTVSDLTGGLKERAGESIDLTEWMSFFFSYDYNMLKEGRDTQGLRRM
IDQSLVDLRWISHIPWSIPYLKMIPGASKNWDDMKAAGDKVARHRVSLGSSRPDLFHHLR
DEEGHEAVRPQLEVVSVDGALAIIAGADTAATTLAHFWMFMLRHPACFERLRKEVDATFA
RDDGPDFVKQARMPYLNACLNETLRLFPPVLAGLQRRVGRGTGGRMIGTHFIPEDTQVSL
VAYTVHRNPDCFSPFPDTFWPDRWLTQETYTLPTGEVIPSSDVLTRRDAFMAFSQGPMAC
AGKNVALAEMRAAVCAVVQRFDLVLAYERALDEWEEVLQECFVSKLGKLPVQVVPRN
CYP5036B1 Phanerochaete chrysosporium (white rot fungus)
JGI gene model genewise.22.99.1
MALLQLAQDVFRRSHPASACYALYHKYLNKPVHPLYHFCLLLVVPAALLALLQAIHRISV
AQECGYALFYWLVMASATVVYRISPFHPLANYPGPLAAKISKLYLAYLTAKGRAHEDVRA
LHSKYGDVVRIGPNELSFNRSDAIQTIYADKTMPKGPYYVARTNLAGVVQLDGVRDFKEH
ARRRRPWNKAMNSAAIKSYEPIVSSTASQLLGQLSKRIHNDVNISDWMSFYGFDFMGRMV
FGREWGMLEEGRDVNDYWHTMDKCLTIVSWSSQIPWSVPIIRLMKPPPEVLKMQKISDDS
AMARLTSEGSGVKDLYYYLLNEDDSSKSELTRDECISEGVLAIVAGSDTAATALTHLCYY
LLTHPDSLQRLRQEIEEAYPTLGSELDDLSRQAEMPYLNACINETLRLLPPVLTGLQRSV
TAGSGAIIAGYFVPEGVDVSVHHYSVHRNLQDFSPIPDTFWPDRWLEQDAYVLPDGDVIG
KGEVRTNRGAFMPFSVGPQQCAGKNLAMVELRAVACGLFRRFDLSLSERMNICDYEKGLR
DAYTTVRGPLYVKLKPRKE
CYP5036C1 Phanerochaete chrysosporium (white rot fungus)
JGI gene models ug.36.48.1 and genewise2nd.119.1.1
old scaf154
47% t0 5036B1, 45% to 5036A1, 46% to 5036A2, 45% to 5036A3
MVDRVDPRLILGSSSLVSVACYLIYKHSEPNNIPAHAALLLGVPALLVHQLGTHWSILQQ
GGAFVAYWALILAFTGLYRLSPIHPLARYPGPTLGKLSKIYLSYLSARGDIYRVIKGWHD
KYGDVVRIGPNELSFRHVDALQPIMGTKYTVKGPYYDTRTTPEQITQMDGIRDYSVHGQR
RKPWLRAMSSAGLKGFEPIVKMKALELVEELSKKVGEIIDMSEWMNLFGFDFMGHLAFGR
EFGLLKSGNDHDDMIRTVEDGVYGAGVISHIPWIAFLVHFPPAMKGLRAMQQMAATFARE
RTQKGSTTKDIYYFLTEDEGAAQSGATHDEVIADGMLALIAGSDTTSIALSHVCYFLLRH
PACAARLRAEVDRAFPPGEDVLDFARHADMPYLNACINEALRLLPPGLGGLQRMVRRGTG
GAMIGPHFVPEDTKLSVHLFSLMRDAREFAPLPDAFWPERWLAQDTYVLPTGDAVSKEHV
TTNRAAFIPFSVGPQNCAGKALALVELRAVTCALVSKFELHKPKDYDLDQWEGDLLDLYI
SIRGKLPVILQARQGR
CYP5037A1 Phanerochaete chrysosporium (white rot fungus)
JGI gene model gx.1.22.1
Jagjit Yadav
Submitted to nomenclature committee July 18, 2005
Clone name PFF-164b also PC-ln-1
Same as scaffold_164b in the whiterot sequence files
41% to CYP5037B1
PPGPPGLPFVGNAYQIPHDKQWLRFDEWIRRYGDLVHISVMGQPTVIIGSAQTASELLDA
RGSIYSDRPQAVMAGELVGWDQGLGYAPGPHSPRFREFRRLFQQFMGPRAAQDSSMLAAQ
EKSATRLLSRLLSTPEEFITHVRQVTGALILYLTYGYEVDEDGFKDPLVNIAEEAMLGFA
RASDPGAYLVDTMPWLKYIPEWFPGASFKQDVKAMRQARERLYDVPYNFVQKAMAEGPVP
RSFVSTYVEEKATPAFADEELIKAAAASLYSGGADTTPSSLASFILAMTLHPDVQRRAQV
ELDSVIGESWQRLPTFADRPNLPYIDAIVLEVLRWHPAVPLGLAHRLSQDDVYRGYYFSQ
GTVFWANIWTMLHDEIIFPDPSRFMPERYLDEHGRLKSMSRFEDPAVIGFGFGRRICPGM
HFAHNSIFIAIARMLYVFNFTKAVDKNGNEITPEVEYSGFISHPSPFVCSISPRSIAAAELVVQ
CYP5037A2 confidential basidiomycete
CYP5037B1 Lentinula edodes (Shiitake mushroom)
GenEMBL AB116638
Hirano,T., Sato,T. and Enei,H.
Isolation of Genes Specifically Expressed in the Fruit Body of the
Edible Basidiomycete Lentinula edodes
Biosci. Biotechnol. Biochem. 68 (2), 468-472 (2004)
Clone name cypfb
41% to CYP5037A1
CYP5037B2 Phanerochaete chrysosporium
AADS01000003.1, JGI gene model ug.1.25.1
scaffold_164c 54% to 5037B1, GC boundary at PIGPL
19304 MIRPLTLLDIALATLAVVLLKTIIARSKQRARY
19403 PPGPKGLPVIGNVLQMPKDREWLTFAQWGEQF (1)
GNIVYLSLLGQP 19582
19583 MIILNSAKDAVALLDKRSSIYSDRPILYMGGELIGWKYILGLTPYGDRFREYRRLMAKFI 19762
19763 GGKTQVERHFPVMEQEATSFLKRILRRPDDLGANIRT (2)19873
19930 HAGAIILKLAYGYTIREDEDPFVTLADRAMAQFTEATTPGAFLVDVFPLLRHMPAW 20097
20098 FPGASFKRTAQEWSDTLNSMADVPHAFVKEQM (0) 20193
AKDTEVPSFTSELLRDEKLQEG 20308
20309 QEFNIKWSAASLYA (1) 20350
GAADT (0)
20465 TVSSIHTFFLTMLLFPHVQKRAQAEIDSVVGTDRLPTFEDRAKLPYVEGVLKEVLRWHPIGPL (1) 20653
GLPHRLAQDDSYEGHLFPKGAIVIANIW(2)
20847 KCLHDPDVYPNPSDFDPTRHLSENGRSPQPDPRDYCFGFGRR (2)
ICP (1)
21085 GLHLADTSIWITCATVLAAFNIENVVENGRVIDIVPEYTSGTIR (2) 21219
21280 HPKPFRCSIKPRSTRAEALIFSD* 21351
CYP5037B3 Phanerochaete chrysosporium
AADS01000003.1, JGI gene model pc.1.248.1
Scaffold_164d 5 P450s on this sequence
12364 MPSALSLLDFAFAALGLIIVKAFLSRTRRQGPYPPGPKGLTIVGNALEMPTSREWLTFSEWGGRY (1) 12170
12115 GDIIYLSLLGQPMVILNSAKHAIALLDKRSNIYSDRPVLVMGGEMIGWKYTLALTPYGQR 11936
11935 FREYRRFIAKLIGGPTQMQTHLPLEEHETRRFLKRLLNEPERVADHIRK (2) 11789
11728 TAGCIILKLSHGYDVREGHDPIVDLVDTATEQFSLATSPGAFLVDVFPLLRYVPAWVP 11555
11554 GARFQKTAREWRKVLERMADEPHDFVKQRM 11465
11412 AENTNVPNYTSELLQNERLDGDKEFNIKWSAASLYS (1) 11305
11252 GGADTTVSAIYSFFLAMTLFPHVAKRAQMEVDAVVGSDRLPTCEDRPNLPYVEALVKEVF 11073
11072 RWNPVAPL (1) 11049
10999 GLPHRLIEDDIYEGYFIPKGSFVIPNIW 10916
HILHDPNHYPNPFEFDPTRFLSDEGRTPQPDPRDYCFGFGRR (2) 10740
10688 RICPGLHLADVSVFLSCAMVLATFDISKAVENGKVIEPEVEYTSGTIR (2) 10545
10488 HPKPFKCTIKPRSTKAEALILSADD* 10411
CYP5037B4 Phanerochaete chrysosporium
AADS01000003.1, JGI gene model ug.1.26.1
Scaffold_164e 5 P450s on this sequence
9887 MSTPLTYLVLLSAILTVVLIRTAIARRKRWARLPPGPKGLPIVGNVLQMPKSQEWLTFSR 9708
9707 WAEQY (1) 9693
9638 GDIVYLNILGQPLIILNSAEDAVALLDKGGSIYANRPILAMGGELVGWNRTLALTQYGER 9459
9458 FREYRRLIARFIGGKAQMARHLPLVERETRRLLQRILNNPEDLAGNIRK (2)
TAGAIILTLS 9222
9221 HGYRIREDDDPVVAHVGRALEQFTEASTPGAFLVDVFPILRHVPAWLPGASFKATAKRWG 9042
9041 ETLEQMADVPHNYVKEQM (0)
8939 ASNKDIPNFTSELLRDEKLGDIDSKEFNIKWAAASMYS (1) 8826
GGADT (0)
TVSSIHSFVLAMVLHPHVQRRAQAEIDAIIGPERLPTFEDRAALPYVEALFK 8540
8539 EVLRWNPVGPL 8507
8455 GLPHRLSQDDVYKGYLLPKGSIIIANIW 8372
8313 xxLRDHNLYPNPSDFDPTRHLPKNTEAASQPDPRNYCFGFGRR (2) 8191
8062 GQHLADASVWLACATMLATFDIENLVASDGTVIGVEPEYTSGTVR (2) 7928
7870 HPKPFKCSIKPRSALANALINAGMPE* 7790
CYP5037B5v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037B5v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037C1 Phanerochaete chrysosporium
JGI gene models pc.2.111.1 amd genewise2nd.2.36.1
Short model, needs more work
MTSTNILLISHGHRVKDSNDRFLKLSDAVTDEFSEAVAPGAFLVDQFPLLRHLPSWVPGT
AWRKTAEKYRRHVADAVAEPFAFVKQQMAAGTAIPSFVSRNLDDGAAPSPDHEHTVKYAA
MALGCADAADAAWQTASALTSLFLAMTLYPEVQRRAQAELDGVVGTDRLPTFEDRDRLPY
ITAICAEVLRWMPVGPLGLPHRLTEDDVYEGYALPKGTIFFVNNWKLLHDPDTYRDPMAF
MPERFLGAAPELDPSKIAFGYGRRICPGILVAEATIFITVAATLAAFSIRPAQNGGAPSL
PPVRQTSGIISHPAPFQCDVVPRSKKAEALVVAAVENR
CYP5037D1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037D1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E2v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E2Pv2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E3v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E3v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E4v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E4v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E5v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E5v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E6P Postia placenta (brown rot basidiomycete fungi)
CYP5037E7 Postia placenta (brown rot basidiomycete fungi)
CYP5037E8v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E8v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E9v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E9v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E10 Postia placenta (brown rot basidiomycete fungi)
CYP5037E11v1 Postia placenta (brown rot basidiomycete fungi)
CYP5037E11v2 Postia placenta (brown rot basidiomycete fungi)
CYP5037E12 Postia placenta (brown rot basidiomycete fungi)
CYP5037F1P confidential basidiomycete
CYP5037F2 confidential basidiomycete
CYP5037F3 confidential basidiomycete
CYP5037F4 confidential basidiomycete
CYP5037G1 confidential basidiomycete
CYP5037H1 confidential basidiomycete
CYP5037-un1 Phanerochaete chrysosporium
JGI gene model genewise.25.75.1
pseudogene
scaffold_11 (1449124 bp) : 785586:787348 (1763 bp) (-) strand
32% TO 5037B3, C-term half = 40% to 5037B2
X = frameshift
MLLRIWSRSQSFHPNVSALLFVTTRACHLMSC
RLPLPPGPRARWYGTIGMPTKSQWLNCHGRKCTVRYGSHYDAPGLLMYFHIVENPMVV
LDTAGTVNDLFEKRGTSYSSRPVTTMVNELYAYAQYSLGGYSLAH (?)
WRKHRHLFHQHFNTSAMHVSRPVVLREAHTFLHNVSRTPVDDWSIVFGGH (2)
ADAIVTMLSYGHQIAPEGEMYVDTRTRLSQ (0)
AYLLLLLAKTRTSL
IYDVVKHVPAWFPGAAFKKQALQWREANRMMLNVPLEKVQ
67 amino acid deletion here
QIDRIFASDKLPTF
ADREDLX
YVDCIVWEYLRWNP (1)
VTPLGLPCQVTEDDTYCGX
YIPKGATIVSNTWY (0)
MYPYLLLFDPDRFADASRNASLGIHELPNAAFER (2)
MCPGRVLAFETI
WITIATTLAGFHLSEPRDEHNEVIQLDTPNTPKLLS (2)
HPKPHQCAVSPRSERALFLVVESLDG*
CYP5038A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.1.1095.1
Necha1/scaffold_1:4194871-4196497
41% to 532G1 new family in 53 clan, close to CYP532 sequences
see fungal pages for seq.
CYP5039A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.30.150.1
Necha1/scaffold_30:313862-315492
33% to 58A1, 38% to CYP58E1 in the CYP53 clan (part C)
see fungal pages for seq.
CYP5040A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_24000105
Necha1/scaffold_24:251478-253220
41% to CYP62B2, 39% to CYP62B1, 39% to 62C1 and 32% to 62A1
in CYP53 clan (part D), probably a new family close to CYP62
see fungal pages for seq.
CYP5040A2 Fusarium oxysporum
74% to CYP5040A1
see fungal pages for seq.
CYP5040A2 Fusarium verticillioides
91% to CYP5040A2 Fusarium oxysporum
see fungal pages for seq.
CYP5041A1 name changed to CYP684B1
CYP5041A2 name changed to CYP684A2
CYP5042A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_37000024
Necha1/scaffold_37:64074-65768
63% to 5042A2 Aspergillus oryzae
47% to 5042B1 Aspergillus oryzae
see fungal pages for seq.
CYP5042A2 Aspergillus oryzae
GenEMBL AP007164.1d, BAE62162.1
Fourth P450 of six on this accession
CDS join(1201326..1201574,1201624..1202814,1202863..1203015)
63% to CYP5042A1
MGASIHAHISAAANESPITAAFVSIAACLGLIFLIIQEIFKPVG
KRRSPQGKKWKLPPGPQGVPIFGSLLYLQKVREDEEHRIHKDLAKYGEMTTLHLGSKT
WILLNSKRVVSEIIAKRGSLTNGRSPMPIASGIVSRDGRSLLLPPAQWMEKRRVMHSL
LSGTAMKQYGSWQELESTQMLAEYLFQPERWYRHHYRYANSVVHRIALGERLVKSGKE
LAELQDVVTHFVGSIGTSLVDWFPELDKLPRMLQPWRKHWEKLGDWNEEVYKSWWIPA
REKVENGTAPPSWVRDVLLHPDTKFTGNDQEAMYVALQLLEAGSDTTREALNIFAMAA
LCFPDKFQKAREEVDSQCSTTKNFRLPGIDDLGNMPYICAMIKELLRWRPIFSFTPDH
VLTSDMEFEGYNFPAGVGFVINEIPVCNECEDPEDFKPERWLDGHETDAAHGLWQFGG
GRRICVGYRLAFQGLFINVARLVFCYNYEAAGPYDSKRLNHHKTVEPFPVKVTPRSEQ
HTSLILEEGARLGVLEDAKRLI
CYP5042A2 Aspergillus flavus
100% to CYP5042A2 Aspergillus oryzae
see fungal pages for seq.
CYP5042A3 Fusarium oxysporum f. sp. lycopersici 4286 chromosome 13 cont2.710,
AAXH01000710
86% to CYP5042A1 Nectria
revised
MISQITPYLSYAFERVPAASFLALSLCLAVLLLVVVAKYFEPVGKRRLRDGRKSHL 901
PPGPPGLPIIGSLHKLKEARGDPDHKYVSFLLSTVERLCRLSLLQLRELATYGEMTTVHL 1081
GSKTWIFLNSSRVVSEIIAKRGSATNTRSPMPISSGIVSRDGRSLILPQEAWME 1243
RRRVMHSLLNGTSLKQYGEWQELESTQMMAEYLFKPHLWYKHHYRYANSVIHRIALGERL 1423
GKSTQELADLQNCVTFFVGSIGSSIIDWFPDLARLPKFLQVWRSHWEALGKWN 1582
HDVYRSWWDPVRKQVENGTAPPSFVRDVLLNEETRYKGDDQDCMYLAMQLIEAG 1744
SDTTREALNIMVMAMLEYPEPFRKARADVDSICGVGEQARLPVLSDMDNLRFICAIAKEV 1924
LRWRPIFILTPDHVASQDIEFEGYLFPAGTGFTINEVPVGNEFEKPEAFYPERW 2086
MDGHEMDISHGLWQFGGGRRICVGYRLAQRSLFLNIARLVQCVDFKP (0) 2227
DGPYNAKILNLESVDEPFPVKSTIRSEAYEALIIKEATESWCFGGRAHGPGATIMMLFIVHTLVS
SLTRLE*
CYP5042A4 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_8000113|Aspni1
82% to CYP5042A2
see fungal pages for seq.
CYP5042A5P Neosartorya fischeri
59% to CYP5042A3
Note: this seq does not have an ortholog in A. fumigatus
CYP5042B1P Aspergillus oryzae RIB40
GenEMBL AP007157.1h, BAE59001.1
complement(join(1170838..1170975,1171028..1172102,
1172148..1172220,1172254..1172488))
revised to match to 5042A1 and 5042A2 but stop codon encountered
MTQLSIETFVVFTAFGLLWLSYEYFRPGSILSRFASMRSKLPPG
PPGLPIFGNMFQFTRARDAGLWGPFVSPGFLPSAASLRQYGPMTTLHMGFQTWVVLNGP
*VATDIINKHGKITS
ERPDMPIAGDLVSHGLRTVIRPTAAWTEGRRVMHHLLSGSVLRIYGNWQEIESLQML
SAYLREPKHWYAHHYRYSIAVLYRLVMGENLSKTQDELNDYQKVTMEITLSSLNSMVD
FFPRLDRWIPIYLQWWRPYWAKMGDFHHSVFKSWWDPIRDAVRQGTANPGFVRDTLLH
PDMRYKGTEEEAMYLATSVIAAGSDNTRMALNTFIMAMISHPETMARARQQLDAVCIN
EDGTLRLPGMADFDRLPYLAAMVKEVLRWRPTTPVTPQHQLTEDLEYEGYRFPKGTCF
VVNGIALGQVCDNPDQFDPSRWLDGNEGNIVHNLWAFGGGRRICVGYRVAQQALYVAI
ARIIFCFDLCADGPIDTRKLNHFHIHNEPFPVRVTVRSAKHEFLIKEEAEKASTAF
CYP5042B1P Aspergillus flavus
99% to CYP5042B1 Aspergillus oryzae
Same stop codon as in oryzae
see fungal pages for seq.
CYP5043A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.32.163.1
Necha1/scaffold_32:163700-165597
40% to 532C1, treat as new family in CYP53 clan close to CYP532
see fungal pages for seq.
CYP5043B1 Mycosphaerella graminicola
44% to CYP5043A1 Nectria haematococca,
40% to CYP5078A6 Neosartorya fischeri
see fungal pages for seq.
CYP5043B2 Aspergillus terreus
57% to CYP5043B1
see fungal pages for seq.
CYP5043C1 Fusarium oxysporum
46% to CYP5043A1
see fungal pages for seq.
CYP5044A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_14000115
Necha1/scaffold_14:293544-295186
32% to 532C1 new family, best matches are all CYP532, in CYP53 clan
see fungal pages for seq.
CYP5045A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_43000032
Necha1/scaffold_43:94104-96134
32% to 548A3 new family in CYP53 clan
see fungal pages for seq.
CYP5046A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.13.299.1
Necha1/scaffold_13:1007168-1008783
38% to 530A2, 40% to e_gw1.14.490.1, 39% to 530A1
59% to CYP5046A2
in the 64 clan
see fungal pages for seq.
CYP5046A2 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000373.1
MIQNVSLSPVLLKLSLLFISPVLLLLTAYFFIVPNVIK (0)
24919 DPRRRKLPPGPKGLPFVGNMLDLADTELVRDKAIAWRKQYGEIFYTKIGGTDYVW 25083
25084 LSSPKVVKDLMDKKSGIYSSRAPAPLAQDVASAGRRQLFMPYGARWRSIRKHSHDLLNLR 25263
25264 SSVKYQPVQDFESKYLLQELMESPDDFILINRRYSASVIMLVTYGYRIPSWNDPLIQRIY 25443
25444 AMLDRFTKMTAPGAHAIDSFPSLASLPQWMLGNWRSHGQRVFEQDSQLNLDLWNRLKRET 25623
25624 DAGTAKDCFTKTFYLKDPAKSGIDDLSAAYTCGGLIEAGSETTGTTLNNFVLCMLLNPEV 25803
25804 QKKAQEELDRVVGPDRLPTWEDEESLPYVRGVIKEVLRWRPVNKFGMPHATSEDDWYEGY 25983
25984 FIPKGSVAVLNWW (2)
AIHRDPELWPNPDAFDPSRYLNHSASAADY 26163
26164 INASDPKTRDHFAYGAGRRVCPGVHVAERSLYINIARVLWGFNLRKKIGKDGQVIEVTEK 26343
26344 MAPGFFSVPENYECDIRPRSAKHAEIMKKQWAEAEKEGLNF* 26469
CYP5046B1 Trichoderma reesei QM941
GenEMBL AAIL01000816.1 4
runs off end, missing last exon
47% to CYP5046A1, 51% to CYP5046A2
MSLLAKIALITPLVGSQNSPYSSHVQSNETFQILWLAYKLWTR
206456 DPRMKHLPPGPQGLPIIGNMLDMADTDKMMTLAKDWADQYGDVFYTKVGLQYFIWLSSP 206632
206633 TAVKDLMDKRGSIYSSRAASPMINMVSNQERLNFLPYGEKWRTLRNILHSALNLETSTS 206809
206810 YKPVQDFESKQALWEILHAKDDTEFSDINRRYSTSTIMTITYGQRVPHLSDPLYQDILKI 206989
206990 VRHFSLATAPGGWMIDTLPMLADIVPEWLLQNWKTVARQWYEEDSRIYLRMYHKLMNDIE 207169
207170 NGTAPDCFLKDMAREKIEKSLISDVTAAFAAGALIEAGSDATTTALNNVILACLLYPEVV 207349
207350 AGAHEELDRVVGSDRMPDFSDEPNLPYIRGIAKETLRWRASTKIGTCHSTTQDDWYKGFF 207529
207530 IPKGAVIVLNWW (2) 207565
CYP5047A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_2000584
Necha1/scaffold_2:1870053-1871983
37% to 619A1, 68% to AAKE02000009.1 Neosartorya fischeri
in CYP64 clan
Neosartorya fischeri CYP5047A2 has an insertion between
PDRY and HEME not seen in this seq.
see fungal pages for seq.
CYP5047A2 Neosartorya fischeri
GenEMBL AAKE02000009.1
Note: this seq does not have an ortholog in A. fumigatus
49868 MSLLSTLLQVPGGAPAVSPILLLTGVL
49948 LVAGIWRLLQIGKRDPRMPKGPPTVPILGNFHQIPSTGLFAR (2)50073
50146 FGEWAKEYGPVFSLKFGPTNIIVLCDRKAVHELLDKRGAIYSDRPPSYVGRLLTQGDHIALE 50329
50330 QMDPVWREKRKVISHNFSPKNLDEKHFLVQEAE (2) 50428
50485 GLILLNDLLRDTEGFYNHVRRYTASVASALAFGHRGPTFESFWGH (0) 50613
50687 AVYDVMDRWTEAMEAGANPPVDEYPILRLIPKRFAYWKRRAVAAGTVFDTTWGKARQIVDE 50869
50870 RRARGDKRDCIIDRLLDEYNQKGWPMSQHAFNNLVGEVVEGAADTTAAQILTLILAFA 51043
51044 MHPHVQEAARREIDAICPPDKPPKWSDFQQLPYINMIVKEGMRWRPV (2)51184
51261 AVTALPHRVRQ (1) 51293
51364 DDWYEGMLIPKDSTVFIATWAIHHNEQIYKDHDVFDPDRYKDHPKLANDYAGSPDW SNRD 51543
51544 KYNPSPLCLKTSSPV
SLHHYGYGAGRRLCPGVHFAERNMWRIAAKLLWAYEFAEPIDPRT 51723
51724 GKTIPLDPNSYNDGILHAPLPYKVRITPRSKQHEETIKKGLQEALDFLSKWN* 51882
CYP5047A3P Fusarium oxysporum
(+) strand 57% TO CYP5047A1 Nectria haematococca
see fungal pages for seq.
CYP5047A4P Fusarium oxysporum
(-) strand 62% TO CYP5047A1 Nectria haematococca
see fungal pages for seq.
CYP5047A4P Fusarium verticillioides
89% to CYP5047A4P Fusarium oxysporum = ortholog
see fungal pages for seq.
CYP5047B1 Grosmannia clavigera
CYP5048A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_43000028
Necha1/scaffold_43:79608-81418
31% to 503B1 in 54 clan
see fungal pages for seq.
CYP5049A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.23.313.1
Necha1/scaffold_23:325069-326664
in the CYP59 clan
see fungal pages for seq.
CYP5049A2 Gibberella zeae = Fusarium graminearum
GenEMBL AACM01000320.1
49% to CYP5049A1
252033 MSVSEFKAPGLLMTILSAT
251976 ALLIAVLYRGYRTRRFYRDL (0)
PSPPHSWLLGHISILKNIALSMP 251797
251796 RNSMPQLYYTEIAHRYKHEGIFYLDLWPIGPSLVIITDPKLIEQAHIPRPMVPHPFTNTS 251617
251616 MAPIAGDDIIPTKSGTEWKKLRNDMSPAFSYTYAHNMVGVIVNESKLLRGKLDELSATGQ 251437
251436 VFSMEELLNKTIFGTVSRHLLNDESYAQKAGRQDLADMRELIDLAREESDPRIAYNPLVQ 251257
251256 IPRRMKRYIIRRRLEASLFGVIYKRLETLVSGGIVPSRQTPTSVLDLILREH
AELAKRENKEGRCNFANLSKFEEKQLLT (2)
IRGLSLGGHTTTTTILS (0)
YLFMLLSKAPHIVDKMHQEHIQQLGPNPQATLLKNPDILSK 250729
250728 LPHTEAVIKETLRLYSVGSGLKLGPPGATVYHQGRHLPIDNNLIIVTNAHGIHYDPNIYS 250549
250548 QPIDFRPERWLSQNKAHPRPGYFRPFGGDGRWCPGQNIAMCMLKVIVVMTIGDYVFECAD 250369
250368 LKPNLKPGTLHTDVDVVFGDIAFQQLLLEGRPRDGMMMTVRKRVQDLTLT*250216
CYP5049A3 Fusarium oxysporum
52% to CYP5049A2
see fungal pages for seq.
CYP5049A3P Fusarium verticillioides
76% to CYP5049A3 Fusarium oxysporum = ortholog
see fungal pages for seq.
CYP5050A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_13000347
Necha1/scaffold_13:996526-998270
45% to CYP5050B1
36% to 5046A1, part of a P450 gene cluster, in the CYP64 clan
36% to 530A1, 41% to CYP5069A1 Aspergillus fumigatus
see fungal pages for seq.
CYP5050B1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.19.97.1
Necha1/scaffold_19:553881-555574
45% to CYP5050A1
see fungal pages for seq.
CYP5051A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_8000422
Necha1/scaffold_8:1042988-1044138
intron 3 begins with gc boundary
29% to 573A3 in 53 clan part B
see fungal pages for seq.
CYP5052A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.70.16.1
Necha1/scaffold_70:45730-47558
new family 44% to CYP5052C1 Aspergillus fumigatus
48% to 5052B1 in the CYP64 clan
see fungal pages for seq.
CYP5052B1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.142.24.1
Necha1/scaffold_142:12270-13802
48% CYP5052A1
see fungal pages for seq.
CYP5052B2P Nectria haematococca (Fusarium solani group)
JGI gene model gw1.36.29.1
Necha1/scaffold_36:100410-101927
88% to CYP5052B1
50% to CYP5052A1
Note probable pseudogene. 3 stop codons and 2 frameshifts
see fungal pages for seq.
CYP5052B3 Fusarium oxysporum
84% to CYP5052B1 Nectria haematococca
see fungal pages for seq.
CYP5052C1 Aspergillus fumigatus
GenEMBL XM_749573
MSDPNTTAVRPVPRVGFATIVLGLIVLGILRWAYACYKWNQKYK
LPARVPGIPILGNSLQVPAVQQGPWAKDLAAKYGEM (2)
FTCQFGGSTWVFLNSSRVVKDLLEKRAAIYNSRPPFPMTQDIISRGGRIVLMPYGER
WRLVRRVMHQILSVTNQPMFQPFQDLESRQLFWDYLHKPDRWFAANGRYANSVIMSVV
FGRRSLLDDPDVAELFETIELFLAEQQPGGESGGCVPGAGELAPVLAVVAAAGRSGFS
RRPSSRQTGTTNPRRYEAKMLRGEFLASKEITQMDEVTKLFVFGSLMEAGSDTSRVTL
GQIIAGAITYPDWVTRAREQLDRVCGAHAERLPGWDDRPRLPYITAVVKEGFRWRPNI
AEIGAPTVLIKDDEYEGSRFPKGTVFTWNAWAIALSPDEYEQPERFWPDRFLNEDLEN
ALKGHGAFGP(1)
GRRVCAGWKVGETNVWIAIARLLYCFDF
HPVPGQPIDTMRIPQLAGNAASFAARVSVRSPAHAELIRRECAEAVKTQY
CYP5052C2 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.15.527.1
Necha1/scaffold_15:823081-824500
53% to CYP5052C1 Aspergillus fumigatus
47% to CYP5052A1
see fungal pages for seq.
CYP5053A1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.7.200.1
Necha1/scaffold_7:1738381-1740021
42% to 546A2 M. grisea, 40% to 546A1, 35% to 546B1 in the CYP64 clan
37% to 546B2, 55% to CYP5053A2 Phaeosphaeria nodorum
see fungal pages for seq.
CYP5053A2 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000022.1
304178 MLLDRLGYEANT
304142 FYYAATACLVLATVVVFVDYGRMLLLRRKLPPGPFPFPIVGNHYQISKDRPWLQWAEWAE 303963
303962 YYNNPMTTIWVGREHRIIVQDAWVASDLLEKRADIFSSRPRFVVMGDLVDATTTNQTTLV 303783
303782 YGDRWRIHRKLM (0) 303747
303691 HGVVGTQAVRGYREAQANESKILTRDLMMKPDDFVMSI (?) 303578
303576 ERYSVSLTSIIGWGRRIKKTNDEVAQLALAVMEAVNYIVPGLYLMEAIPILSKLPSFIYS 303397
303396 TPSKIKAGANLFSKYFYFLTQEGAKVDGPTFAANLIEAQPKMNLSNKEVSGLAANLIGG 303220
303219 GVDTTSSTMLSFILAMAYFPDVQKKVQAEFDAVVGHDRSPNWDDVDKRLPYLVATVKEVL 303040
303039 RWRTVTILAGIPHANTVDFEYRGYHIPAGTNITGNMWAIHRNPRDFPDPDVLRPERFLNG 302860
302859 LEKPYPNQRGSNPFGWGRRQCSGQPLAEQGLYYSLARIAWAFNIQPGLDKH (0?) 302707
302636 GNEVKLDIFAYTNTENMRPEPFEVRFSPRTPKIQDMILSEAMIASEDLSIYDWETK 302469
302468 VTIKDALQDA* 302436
CYP5053A3 Mycosphaerella fijiensis
58% to CYP5053A1 Nectria haematococca
see fungal pages for seq.
CYP5053B1 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.28.146.1
Necha1/scaffold_28:468415-469853
49% to CYP5053A1, 44% to CYP5053A
see fungal pages for seq.
CYP5053C1 Aspergillus oryzae
GenEMBL BAE64935.1, AP007171.1
45% to CYP5053A1, 44% to 5053A2, 39% tp 5053B1
14 P450 genes and 2 pseudogenes on this contig
revised 3/24/2009 added N-term. Probable gc boundary after HFQM
MIVERVEQLFALIQGQRILSHPGWSHVNFATLIPPVVVILGLALIVDYGYMIYLHFQM (0)
PPGPFPLPMIGNTHLLPDQKPWIYFEQLAKEYNTP
MVTFWTGRRPTIWICDAWAADELLNKRAAIYASRPRMVVFSELGAGQSNMVN MYYGDRWRLHRKLTHMGV
GLQQVRNYRGFQNDESKVVALDLLREPREYVSHFERYATSVVSIIGFGRRVSAYTDPIITEVVAVMQRAA
ELNVPGKSFPMLMESFP (1)
FLAKFPNWMAPWKHGLGNGQGRGRPFFYALAEEA
ASGPEAKQCYARKLFEEVPKHNLTKMEI
SSLAGNLFGAGSDTSSSTLVTFVLACCAFPETLPKAWEELDRVVGPHRSPTFEDESDLPYV
RAFVKEVLRWRSVAIIGGQPHAPIKDDRYK (0)
GWLIPRNTWVQGNVWAIHHHEREFPEPDRFNPERYFEESPVHRPFPVDKGYMTFGWGRRV
CSGQGLAEQGTFITIARLLWGFDIRKALDRHGNEVPVDIFDFT
NGLNMRPNSFECRITPCNQEIRSTIEREGLQALQDLSQYDGETKYRMSTYYNPEKL
CYP5053C1 Aspergillus flavus
98% to CYP5053C1 Aspergillus oryzae
see fungal pages for seq.
CYP5053C1 Aspergillus terreus
82% to 5053C1 Aspergillus flavus
see fungal pages for seq.
CYP5053C2 Mycosphaerella fijiensis
JGI gene model e_gw1.14.529.1
68% to CYP5053C1 Aspergillus terreus
see fungal pages for seq.
CYP5054A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_18000233
Necha1/scaffold_18:681283-683153
38% to CYP504E1, 38% to 504A1, 36% to 504A2,
only 30% to 504B2 in CYP64 clan
see fungal pages for seq.
CYP5054A2 Aspergillus niger
JGI gene model e_gw1.6.818.1|Aspni1
63% to CYP5054A1
see fungal pages for seq.
CYP5054A3 Grosmannia clavigera
CYP5055A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_187000002
Necha1/scaffold_187:6622-8491
new family, in CYP53 clan
see fungal pages for seq.
CYP5055A2 Gibberella moniliformis 7600
GenEMBL AAIM01002625.1
AAIM01002626.1 = N-term exon 1
59% to CYP5055A1 runs off the end
Missing exons 2 and 3
same contig as CYP628B1 about 16.5 kb apart
also Fusarium verticillioides FVEG_04314 revised
MLLDIHTSIFRIAV
322 LTLCALLVLKVAVSIIYNFFFHPLSKYPGPPLARISRLWSRIGNFQGRKSERIHEAHVRY 143
142 GSVVRVGPNKLSFSTPTAVQAIYTSNDFTKEESFY (0) 38
RAKRIFHENHLFSFR (2)
DAEAHKTRRKNFSRGFSQSSMLDFEPHVSSKIKALLNQWATRANDGPIDVYPWCHWLGFDVI (1)
24778 YHLMFDEDPGSVPRGQPHQVMRYIKAWKPTYIY (0)
KEFLPQMEQYGVYVPGTIGGYFRDVRTWKK (0)
YALKLIEEIRQKDSHTPFLRNVLSA 24419
24418 EKSGDAAQPLTNSELAEECMGGM (2) 24350
FGGSGTTANTFVYILWACLKQPNVVAKLRSELLQA 24178
24177 FPEPGLVPDYQ (0)
AVINETLRRYPTIVARSPRTAN 23998
23997 NDTVIDGIPVPKG (0)
TIVGTQNFTMHRNEDAFPSPEDFIPERWLA 23818
23817 ADGKETLKASWTPFSVGSRRCIGIN (2) 23743
23692 LAQMELSKLTAAFFLRFDARVDEAMTEEDMRMYDTSNAGPAGARLFVHMREV* 23534
CYP5055A3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_2000945|Aspni1
56% to CYP5055A1
see fungal pages for seq.
CYP5056A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.7.522.1
Necha1/scaffold_7:284482-286156
34% to CYP665A1 in CYP64 clan
37% to gw1.271.3.1
see fungal pages for seq.
CYP5057A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_19000220
Necha1/scaffold_19:595776-597672
39% to AAGI01000353.1 Phaeosphaeria nodorum, in CYP53 clan
see fungal pages for seq.
CYP5057B1 Phaeosphaeria nodorum
GenEMBL AAGI01000353.1
frameshift at 42065
40782 MATTLLHRDSLSHFGVVGLAFLLSVCYVTFF (0) 40874
40948 LVRRLLLSPIRTVPGPLRARLSQWPMIIQGLKGRRIY (0) 41058
41114 ELERLHRKYGSIVRIGPNEVSVADWRHMRAIYSNPKTVIKDPAFYDGVRMIGKHNIFQMTQVRPHLL (0) 41314
41355 HAARRKLSSPPYALSSITRLDPLIQKNADNLVNRLILGVSSSASGTVDAYELC 41513
41514 ALFSLETMCQAAFAKKFDKADGPEGSLELLRSLEGSALRFLPQSLFPFLGSTGLGIKLPG 41693
41694 FIGDAYRCHQIWEQQSRKMVDHFLEKSSADDKYLLSPVATGIDTFLDRRLSHEELIE 41864
41865 EAMGYMFAGSGTTSSTLTYLLYAISLPENLDIQERLREAVQKLPADDVTTIRQDPYVNAV 42044
42045 IKETFRL 42065
42067 FPTIVSTLPRLLLEPLQLDEYRLPAGTIVGMQNWMHHRDPVVFPNPDQFLPDRWLVPN 42240
42241 ASSHAMESSLTPFSIGRRNCIGQNLAWEELYIAVGAIMRAGLKLCLGPEMQPWEM 42405
42406 EIVDRFNIAPKGQRLMLHVTRD* 42474
CYP5057B2 Gibberella moniliformis 7600
GenEMBL AAIM01002904.1
55% to CYP5057B1, 40% to CYP5057A1
5687 MSGLFDNILGLSREALLAVLSVSLCLVYVSIK (0)
5540 IVGRLLFSPLRHVPGPSSTKLSGAAVWLSTIQGRRVY (0) 5430
5370 KLEELHKKYGPIVRTGPNEVSISDWRHLRTIYLNNKGMIKNPDFYEAATFVGKDNIFQMI (2) 5191
5102 NVQQHAARRKMSSPPYSLQSVALLDPLIKGNARRLAQRLKSGTSSPVDAYTFCGLF 4935
4934 SLEVICQAGFAKDFSNDTNGAAALKLLQAMDGSALTLLFDGALPFVARFDIGTKLPGAIG 4755
4754 DSYLKREYWRKKSYEMVDHFLEKSADDEKYLLTPLATGVDGYLGRKLTHEELVEEAM 4584
4583 GYMFAGSGTTSSTLTYLLYELSKPENAAIQERLRTEVLAISDDDIVAIRNNAYINAVI 4410
4409 KETLRAHPTIISTIHRLLTEPLTLGQYTLPSGTVIGMQTWLHHRDTSVFPDPEKFIPE 4236
4235 RWLNETPEMKSALTPFSLGKRNCIGQNLAWQELYWSVSEVMRSGSRFRVAEE 4080
4079 MKDWEMEMEDRFNIAPRGRRLMLTVSQVN* 3990
CYP5057B2 Fusarium oxysporum (temp 5057B3)
91% to CYP5057B2 Gibberella moniliformis
see fungal pages for seq.
CYP5058A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_24000015
Necha1/scaffold_24:34924-36641
31% to 543A1 , 30% to 502A1
see fungal pages for seq.
CYP5058A2 Aspergillus fumigatus Af293
GenEMBL XM_742056.1 also AAHF01000014
54% to CYP5058A1
Gene prediction has wrong N-term (first exon)
complement(join(661025..661409,661471..662275,
662337..662700,662860..662895))
locus_tag="Afu8g00560 fifth P450 of 8 on this accession
MIISSYHLLWLALVAFILQYVAGIVSTRQRRQGAKVPPGPKG(1) 86
139 GWPFLGSAPALAAVDTNGIIGIFKSWAEQYGSITQFSAMGDKQVILTEDKDARELFV 309
310 RRGIKYSDRGAPHAVEYISMKQNPGFRPKDDGWRRQRSMIQSAINITSINKYQSLMDDEA 489
490 TFTVNALLQSPDSFHGEFLRYSYSVLTSSLLGFSVRSPSDPFIHHNETFTAELMNSFRPD 669
670 CFPSNVFPVLRKLPMWLLPSLRTMERLRKEYVGEMWAFRRKIEKLVKEGSATECIYKHFL 849
850 LHRDQYNVTEEESVHTFQAMIDGGTRSPHNNLLTFLFLMMEFPEWQKKLQEEVDRVVGRD 1029
1030 RMPSYRDIPNLPTVRAIVKETVRYRSIVAEMGIGHCLQTDDIYKGYFFEKGTVFNAIFAS 1209
1210 ILMDKDTYPDGKLFNPARWLEPSYPTYKEPLTTYPNCQGFPAFGYGRRACPGVDFAERTL 1389
1390 VIMFAKLGWTMNIRWPRDEDGNELREELQYEPVPAPRPLKFGCRLEARDADRAKIVEE 1563
1564 AAKHLKLQ* 1590
CYP5058A3 Aspergillus clavatus
AAKD03000007.1
91% to CYP5058A2
see fungal pages for seq.
CYP5058A4 Metarhizium anisopliae var. anisopliae Ma23
CYP5059A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_6000721
Necha1/scaffold_6:2168361-2170789
33% to CYP559C1, 31% to 559B1, 30% TO 559A1, in CYP54 clan
see fungal pages for seq.
CYP5059A2 Fusarium virguliforme
GenEMBL CG810696.1 genomic survey sequence
70% to CYP5059A1, first two exons only
696 MYSIWIFLAAVVVWRLYTAYGHLSKVPKGVPWADTSKFTPYLFSQMNNIRNTAAAIDEGYQK (0) 511
461 YSKNGTLCALALPFSRPEILIPQKLIQWATTQPNKVLSPTPVQHEVIAVDYTFLDSSVGK 282
281 GNVAYDILRIQLNRHLPKLIPEIMQELAGQIDETFGFDTEWKEVQAFLLVREVMAKATAR 102
101 LILGDTL (1) 81
CYP5059A3 Neosartorya fischeri NRRL 181
GenEMBL AAKE02006477.1 55% to fgenesh1_pg.scaffold_6000721
AAKE02001791.1 65% to fgenesh1_pg.scaffold_6000721
about 60% to CYP5059A1 Middle region not in database
627 MFPLIILMLGAVAWRMYTSIKHLSTIPKEVPWVGRTGTFSTYLSSQIQAIRNTPSAINEAYNK (0) 815
862 YNKNGAICAIPLPFSRPEILVPRSFVRWMLSQGDAILSPLPVQNEIVGPKYVFLNPSVHG 1041
1042 DYAVYNVLRAKLNRQLPMLIPAIMEELAARVDQFWGMDTDWREVQSHPLVRNVVGRVSGR 1221
1222 IILGSPL (1)
2 ALKETLRLRTSIKALAMQVTAPSGITLDGGKLRLPQGSRLSVSSWGIHHDEEIYPSASTF 181
182 DAFRFSRPREGGETADANAATNGNDNKHLMVSASETYLPFGMGRHSCPGRYFAAIELKLL 361
362 LAYLAVNYDIKLAGERPAFVSIGHFPIPPLNGKLMIRRKRGTAVGMDDPTGV* 520
CYP5059A4P Gibberella zeae PH-1
GenEMBL AACM01000113.1
note new Pseudogene not in Fusarium graminearum collection
2807 EIDKNLSQCSLAIMPSAIGIDIFPPFMQPIAAHLTCFLYDSLLDVRTEDLGCPIHVDAIE 2628
2627 IDNEISKTQPQNDIMTWHIKEALRKKESR 2541
2512 IASRIFATTMAALEAVTLAVAHALFCVGSSNSSAQIWRALEEEARHILHRPINQDSVD*L 2333
2332 HFADAAIKEHLRLQTAIKALTVQVMHPTGITIKDIGVYQRQGAHISVLA*GIHHDEYIYP 2153
2152 NAYTYDTFRFAPQRRNACNSEGSDDEYLMTTPSEKYLSFGFGKHVCPGRQFA 1997
CYP5060A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_24000138
Necha1/scaffold_24:351790-353582
29% to 609A1 Magnaporthe, micro exon 11 bp at heme region
see fungal pages for seq.
CYP5061A1P Nectria haematococca (Fusarium solani group)
JGI gene model gw1.14.57.1
Necha1/scaffold_14:171902-173237
38% to 68A1 missing N-term, two stop codons,
39% to 68D1, 39% to 68L1 42% to CYP5061B1, 44% to 5061B3
possible pseudogene of CYP68 related genes
cannot find N-terminal with any confidence, first exon may be missing
see fungal pages for seq.
CYP5061B1 Aspergillus terreus NIH2624
GenEMBLAAJN01000160.1
16164 MTVILDVLDTHHLVQ
GIAVALLLVFVSSFYGDLADGIPYRNIPLVGRSRWEISNKKAKQRFVSSAKELMAQGFSQ (0)
GRTVFQLMFAQSATIVLHPKYVNEIKNNPSLNFDEANKK (0?)
SFFGSKIPGFEPFDGIDKEGILLEVINKKLTHTL (1)
GQLTIPLSRETATVLSEKLPKSG (1)
16898 EWQSFTFAQEIPHIVARLSSLVFLGQKICRNQEWLNVSVNYTIDAFLAARDLRLWPSVTR 17077
17078 RIVHWFLPSAKRLRHHTVVATEIIQAEIQKRELIRTGKLPEEDPPRTHADALDWFAEVA 17254
17255 AGRPFNVIRSQIGLSLAAIHTTSNLLTNIMYDLTAYPEHIQPLRDEIKAIVDEDGMLKK 17431
17432 TSLTKMKRMDSVMKETQRLNGAGI (1) 17491
17569 AFLNRIAMDEVILSDGTRIPKGASITVSAHHMRDESIYPDAQTYRGFRFYDKRQEAGN 17742
17743 EHRFQFVTTSPEHLGFGHGIHACPGRFFAANEVKILLAHLLLKYDWKFAEDVGAGRPPNI 17922
17923 MHGVENICNPTIKLLYKARQPEVDLAALGEGAE* 18024
CYP5061B2 Aspergillus fumigatus A1163
ABDB01000053.1
Aspergillus fumigatus Af293
Also on GenEMBL XP_750704.1 from genomic seq AAHF01000006.1 chr 6
42% to 68L2,
91% to CYP5061B2 Neosartorya fischeri = ortholog
Note: CYP5061B4 was part of this sequence and the two are now combined
see fungal pages for seq.
CYP5061B2 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000017.1
70% to CYP5061B1
530186 MALISELLQSPYFLQGIAVSLLLVVVSNFYRKLVDGFPYRNIPLVGRSRWEITNSKAKER 530007
530006 FVASAKALFAQGFSQ (0)
GKTVFQMMFSHSPMIVLHPRYMDEIKSHPHLTFDEANRK (0?) 529794
529750 AFFGAKLPGFEPFGLDKEGIALDVINKKLTHTL (1)
GSLTISLSRESAAVLKETLPPKSD (1)
EWQSLVFAQEIPYIVARLSSLVFMGEK 529394
529393 VCRDKEWLHVSVNYTIDAFGAARDLRLWPSITQSLVHWFLPSTRRVRKHISVAKKIVQKE 529214
529213 IEKRELIRQGKLLEYSPLKPDDALDWFREVAAGRPYDMTKSQISLSLAAIHTTSNLLTN 529037
529036 VMYDLIAYQEYIQPLRDEIVAVVKEEGCLKKTSLTKLKLMDSFMKETQRLNPVSI (1) 528872
528819 ASLQRYALADITLSDGTFIPKGAMLVISAHTMNDESIYPHADTFDGYRFYNKRKVPGNEH 528640
528639 RYQFVTTSNEHFAFGHGLHACPGRFFAANEVKILLIHLLMKYDWKFAEDRGRPQSLMH 528466
528465 GTEIICDPNVKLLYKARTPEIDLSKLGELPTDSPSV* 528355
CYP5061B2 Aspergillus flavus
100% to CYP5061B2 Neosartorya fischeri
no oryzae ortholog is found
see fungal pages for seq.
CYP5061B3 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000005.1
78% to CYP5061B2, 73% to CYP5061B1, 44% to CYP5061A1P
591865 MALISELLESRYLLQGIALAFFLVIVSHFYQELADGYPYRNIPLVGRSRWELSNGKAKDR 592044
592045 FVKSAKELMAQGFSQ (0)
592170 GRTVFQLMFTHTPMIVLHPKFIDEIKSHPHLNFDEANKK (0)
592344 AFFGSKIPGFEPFEGLDKDHILLDVINKKLTHTL (1) 592445
592496 GNLTIPLSQETAAVVKETMPPRTD (1)
EWQPLMFAREIPYLVAR 592675
592676 LSSLVFLGEKICRDKEWLNVSVNYTTDAFIGARALRLWPTITRPVVHWFLPSTRRVRKHI 592855
592856 RVAKKIVQDEIQKRELIRQGKLPAEDPPRTHADALDWFREVAAGRPFDETRNQIGLSLAA 593035
593036 IHTTSNLLTNVMYDLVAYQEYIQPLRDEIRAVMEEDGSLRKTSLTKLKLMDSVMKESQRM 593215
593216 NPVSI (1)
AFLQRLAKADLTLSDGTYIPKGATLIVSAHAMRDE 593395
593396 SIYPDANQYDGYRFYNKRQEPGNEHRFQFVTTSPEHFGFGHGIHACPGRFFASNEVKILL 593575
593576 IHLLMKYDWKFAEDKGRPQGFMHGTEIICDPRVKFLYKARTPEIDLSSLGEGLAA* 593743
CYP5061B5 Aspergillus oryzae
GenEMBL BAE57341.1
73% to 5061B1, 45% to 68D1, 41% to 68L1
68% to 5061B4
MPVLATFLESHYFFQGIAVALALIFVSNFYRELADGLPYRKIPLVGRSRWEISNTKAKKLFVTSAKDLMV
QGFSQGRTVFQAMFTAGPTIVLHPRYVDELKNHPHLDFGEAVRKSFFGATIPGFEPFNNQTKEDIVIEVI
NKKLTHTLGQLTIPLSKETAAVLTDKLPGSDEWKPFTFAQEIPHMVARLSSLVFLGEKICRNETWLDVSV
NYTIDAFNAARELRDLPAVARPFIHWFMPSMQKLRHHRKVAAEIVQQEIIKRDMIREGKLPEENPPRTHA
DALDWFREVAAGRPCDETVSQIGLSVAAIHTTSNMLTNVMYDLTAHPEYIQPLRDEIKAIVEQDGILKKT
SLTKMKLMDSVMKESQRTNPVSIAFFNRIATEAVVLSDGTSIPKGANVVVSAHVMEDESIYPNAKVYDGF
RFYNKRQVPGNEHRYQFVTTSPEHLGFGHGMHACPGRFFANNEIKILLAHLLLKYDWKFADRVDRPKSFL
HGTEIICDPTVKLLYKSRQPEVDLSALGEGTTD
CYP5061B5 Aspergillus flavus
99% to CYP5061B5 Aspergillus oryzae
see fungal pages for seq.
CYP5061B6 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_4000153|Aspni1
73% to CYP5061B1
see fungal pages for seq.
CYP5061B7 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_15000297|Aspni1
52% to CYP5061B3
see fungal pages for seq.
CYP5062A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_7000468
Necha1/scaffold_7:1339234-1341197
59% to 5062A2
see fungal pages for seq.
CYP5062A2 Botryotinia fuckeliana B05.10
GenEMBL AAID01003245.1
59% to CYP5062A1,
posible GC boundary at intron 7 after VRIL
MPLPLSLLAECTAFVLVGLCLI (0)
10810 RIAREYFSPLSSIPNAGVCAPYSRLLWAFPTEFRGRITLDLPKLHQKL (1)
10614 GPLVRIGPNEVSFYSMEMYDAVHKVNSRFKKDPRVYGEFVQGGSPALFSIT (2)
10447 DPVEHSKRRRLMGQLFNRSQMHKLEGLMLHHIEGFVQNIASSRDGVDLL 10268
10267 PVCRALEADIM (1)
SDFSFGHTIGALDAYFQGAELDMIAKNDQKATWMPL (0)
LTSFPGLCNTCERTEQIVSSITGYRTPYSKAMLDFHQ (0) 9908
WAERSWRTALSNNASQEKSTSPFPNLVQTMVNSNLPSSTA 9733
9732 LSEATENLGPGTDTTSATLAHILWALGSNPGFQEDLFQDLVTVSFATDMTTLEGIPRLRA 9553
9552 CVKEGIRWTSAATAMLPRLAPEGGAEFYGHFLPENVRIL (0) 9436
9377 TVISSSPVWYLHDPVAFPRPKDFDPYRWLTSDGQNIRDDPLRDKFYIPFSKGANI 9213
9212 CMGAH (2)
FAYLELFLSISQVIRNFRVQTHPWSQPRSYPDEAKGSSPGVFQPVELPNRREWVAAVPTERLMVALEPRL* 8922
CYP5062A3 Grosmannia clavigera
CYP5063A1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.8.270.1
Necha1/scaffold_8:576949-578514
35% to 663A1 Aspergillus nidulans, no introns
see fungal pages for seq.
CYP5063A2 Aspergillus fumigatus
GenEMBL BX649605.1
56% to CYP5063A1
44210 MAATSVVAVIVIGLLTVLYISRKNGKKTDKVLLKLPLIGDLHSSPIEKPLANWDSWAQQN 44389
44390 GPIAVPKLFGIIPIVVLNSYEAATELFNRRSQWYSNRPPSVSMEMITGAPPGRSRFTLMH 44569
44570 DYDDHLKLHHRILSPSLGALAAPKYQPLMELEAKQLLHDLVKALQHSPDGATISTNTIYP 44749
44750 LLERTQSSVILALHYGLRIPHPDERILHQVIDIQVQVTHLAANPALPDLIPALRHLPAIL 44929
44930 SPWKRAADRLYAAQVDLYMRLFHHGRDAAGWNATKQALSTAAKYAPASSSSSSSSSSSSS 45109
45110 SSQIPDLDLAFTLATSIQGGMETSPRQLLWLFIAALHQPSFVTRAHAVLDEVVGRDRLPR 45289
45290 FSDRAQLAFIDAVAHELFRWRPIAPGSIPRRADRDDEFQGVKINKGVTIMANAWGIGRDE 45469
45470 QVFDPALGDLQEFVPERWLRAGEAGEERLRSDLPLPVFGQGRRICQGRRVAVDGTFLQV 45646
45647 ASLLWAFDVAMVDDGAGPVDPWEMVVVGFMTMPKERRFKLKPRGDWVLDVIKREWETAEK 45826
45827 SLDKVMGTNDVE* 45865
CYP5063A2 Neosartorya fischeri
93% to CYP5063A2 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5063A3 Aspergillus niger
JGI gene model e_gw1.8.180.1|Aspni1
70% to CYP5063A2
see fungal pages for seq.
CYP5063A4 Fusarium verticillioides
55% to CYP5063A3 Aspergillus niger
no introns, not found in the F. oxysporum genome
see fungal pages for seq.
CYP5063A5 Aspergillus clavatus
76% to CYP5063A2
see fungal pages for seq.
CYP5063A6 Aspergillus terreus
79% to CYP5063A2
see fungal pages for seq.
CYP5064A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_14000017
Necha1/scaffold_14:53762-55160
top half of gene 48% to AP007159.1 Aspergillus oryzae
There is a sequence gap after IIKAW
49% to CYP5064A2
see fungal pages for seq.
CYP5064A2 Aspergillus oryzae RIB40 = Aspergillus flavus
GenEMBL AP007159.1, BAE59846.1
join(1096818..1097070,1097124..1097466,1097500..1098547)
This gene seems to have an AT boundary instead of GT at intron 3
49% to CYP5064A1 partial seq.
1096818 MDFGGILLHLEARSMATVLIAGLLVYWVGSAIFLAVVHPLAKFP
GPKLAAASDWWLVYHEWFLGKSLTDILFDLHQNY (1) 1097052
GPVVRYGPYR (0)
LHFSSMQAYSDIYNVKSKWDKDPEVYKAIVDTSSAFGLRNYH
EAKERRDLIWPFYSRQSVQRMQKAINRQ (0)
1097494 ISFLVDQLDKQNQEGKLSNMS
MAFRCLAQDIMADICLGKSFGTLEERDFGSPLIHALDEGLESYVLMKSFPTLRNILYS
ISAMVTLPGEAEFATYGTIVADHVTRGIQQPDTIPPNTMLGFLVPTSSNTAKEAPQPK
LSQGHMTEELQTFVIGAGETVASAMVQGLSGILQSPDLYKNVYEEIVQVW PETDGPVP
PIEVLEKLPLLTAVIKEALRLTHGVVTPLARVISAGGACIDGHHVPGGTSVGTSHVFI
HMSSDYYDAPDEFRPERWLGSSSDKHLVAFSKGPRGCMGINLAWCQLYLVLATLVRTV
QMEYPADLNDIKIKWKDCFQPLYYGRPLQVRCTRAEGHS* 1098547
CYP5064A2 Aspergillus flavus
GenEMBL AAIH01000146.1 = AP007159.1 Aspergillus oryzae
only 1 aa diff to CYP5064A2 of Aspergillus oryzae
20049 MDFGGILLHLEA
20013 RSMATVLIAGLLVYWVGSAIFLAVLHPLAKFPGPKLAAASDWWLVYHEWFLGKSLTDILF 19834
19833 DLHQNY (1) 19807
19730 GPVVRYGPYR (0) 19701
19642 LHFSSMQAYSDIYNVKSKWDKDPEVYKAIVDTSSAFGLRNYHEAKERRDLIWPFYSRQSV 19463
19462 QRMQKAINRQ (0)
ISFLVDQLDKQNQEGKLSNMSMAFRCLAQD 19283
19282 IMADICLGKSFGTLEERDFGSPLIHALDEGLESYVLMKSFPTLRNILYSISAMVTLPGEA 19103
19102 EFATYGTIVADHVTRGIQQPDTIPPNTMLGFLVPTSSNTAKEAPQPKLSQGHMTEEL 18932
18931 QTFVIGAGETVASAMVQGLSGILQSPDLYKNVYEEIVQVWPETDGPVPPIE
VLEKLPLLTAVIKEALRLTHGVVTPLARVISAGGACIDGHHVPGGTSVGTSHVFIHMSSD
YYDAPDEFRPERWLGSSSDKHLVAFSKGPRGCMGINLAWCQLYLVLATLVRTVQMEYPAD
LNDIKIKWKDCFQPLYYGRPLQVRCTRAEGHS* 18320
CYP5065A1 Fusarium graminearum
AACM01000442 FGcontig1.442_scaffold7
name changed to CYP5065A1 formerly CYP546B1
see fungal pages for seq.
CYP5065A2 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.229.8.1
Necha1/scaffold_229:6813-8646
86% to 546B1 probable ortholog
genome annotation in progress
name changed to CYP5065A2 formerly CYP546B2
see fungal pages for seq.
CYP5065A3 Fusarium oxysporum
90% to CYP5065A1
see fungal pages for seq.
CYP5065A3 Fusarium verticillioides
96% to CYP5065A3 Fusarium oxysporum = ortholog
see fungal pages for seq.
CYP5065B1 confidential basidiomycete
CYP5066A1 Aspergillus fumigatus
GenEMBL AAHF01000014
no introns
756944..758524
locus_tag="Afu8g00220" seventh P450 of 8 on this accession
89% to 5066A2 in CYP64 clan
Note: CYP5066A and CYP5067A are close in Aspergillus fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA dioxygenase
they are probably working in a pathway.
MERLPLSPAVLFLIIVLPILYLWIRYTAPARPHGKHLSLPPGPP
RLPKIGNLHQVPRQIPWKKYKEWSDTYGPIMSVQLADTIAVVFSSWDLIKNHIERRNT
IYSSRPSVPFFLHATGGLNASILPYGPEWKLQRAIRSSVLKPSMTVKYRDVQHVETTQ
LLHELLSTNDFPVCLRRCIASVFLTVAYGERCVDHAGLEAIDRLEELNRAIALHAEAL
FSGAAGILTQLVLPKALVDRLPVRWKKDADMLHNRLTADLVARTRAALVRPGWNWVKE
FSMKDGIGSGDGDGEQGSKVELKRLAYMVGSLYEASMAASQALRVIILAGLLHPDATR
RMHDELDAVVGTGRLPDFHDAAQLPYTQAFIKEAMRWRSLTPMGSPRATSDEDECRGY
HIPCGATVLVNVWAINHDEAIFLDPFAFQPERWIENPDLPQLMYGMGQRACPGRHMGQ
DSLFLATARLFWAFDMALPDGADPIDQERFLDSGTTLAAFLPDFEVRFTPRSEKYQEV
IENSMAVLPDVLSISATP*
CYP5066A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000012.1
89% to CYP5066A1 no introns in CYP64 clan
Note: CYP5066A1 and CYP5067A1 are close in Aspergillus fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA dioxygenase
they are probably working in a pathway.
28112 MERLPLSPAVLFLTITLPILYFWILHTSPARHHGKQLPLPPGPPRLPKIGNLHQVPRQIP 27933
27932 WKKYKEWSDTYGPIMSVQLANTIAVVFSSWDLIKTHVERRNTIYSSRPSVPFFLHATGGL 27753
27752 NASILPYGPEWKLQRAIRSSVLKPSMTIKYRDVQSMETTQLLHELLSTNDFSVCLRRCIA 27573
27572 SVFLTVAYGERCADHAGLEAIDRLEELNRAIALHAEALFSGAAGILAQLVLPQALVDRLP 27393
27392 VRWKKDADILHNRLTADLVARTRAALARPGWNWVKAFAIKEGTGSGEGDGEQGREVGLKR 27213
27212 LAYMVGSLYEASMAASQALRVIILAGILYPDATRRMHDELDAVVGKDRLPDFNDAAQLPY 27033
27032 TQAFIKEAMRWRSLTPMGSPRATSDEDECRGYHIPRGATVLVNVWAINHDEGVFLDPFTF 26853
26852 KPERWIENPDLPQLLYGMGQRACPGRHMGQDSLFLGTARLFWAFDMALPDGAEAIDQERF 26673
26672 LDSGTTLAAFLPDFEVRFTPRSEKHREVIENSVVVSSDVSSVTVAT* 26532
CYP5066B1 Uncinocarpus reesii
43% to CYP5066A2
see fungal pages for seq.
CYP5067A1 Aspergillus fumigatus
GenEMBL AAHF01000014
most like CYP68 family, may be a subfamily of CYP68
join(752285..752491,752557..752673,752735..752834,
752888..752956,753007..753597,753667..754008,
754032..754078) model revised at intron 4
locus_tag="Afu8g00240" sixth P450 of 8 on this accession
37% to 68A1 Gibberella fujikuroi, best hits all CYP68
Note: CYP5066A4 and CYP5067A1 are close in Aspergillus fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA dioxygenase
they are probably working in a pathway.
METLDAIQLPYLGVVGASLIVILGIILLFPLGSDPFITINQHPRDLFQTKAKQQFEYNAAALLNEGLQT (0)
GHSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDP (0)
VLLVDLPGLESMFQGSLHNQVPPMAVRALNKEL (1)
VHLTPSLSEEAMNCLQTRWTDS TGTC(0)
TEWHGVSIPETVLALIAQMTTRALLGPELCRNPEWLDIAKSFTTNRAIAVAAVQS
WPSFLQPVIHWFLPPCRALRRQIQCARNIILPALERERRAYCSDQPTKREFSNLVFID
QYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIEPLREEVVSVVGNHG
LHRHSLRKLTLMESVMKETQRLEPAVI (1)
IGMFRLAKEKVTLKDGTVVPKGTNIAFANDL
RFDPEMYLEPETFDGYRFQRMREDPAKIDLAPFTKTRMSHLAFGHGKHACPGRFLACD
EAKLILCHILLNYDIRAVEGSPPEL (1)
PGSWGNDVGEKTAGD*
CYP5067A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000012.1
92% to CYP5067A1
Note: CYP5066A2 and CYP5067A2 are close in Aspergillus fumigatus
and Neosartorya fischeri, separated by a phytanoyl-CoA dioxygenase
they are probably working in a pathway.
33060 METFDAIQLPYPGVVGASLLVILGIILLFPLDTGHFISINQHPWDFFQTKAKQEFEYNAA 32881
32880 ALLNEGLQT (0)
32788 GRSAFRLVTNMVTYLILKDQYAEEIKNDSRFGAHEAVDP (0)
VLLVDLPGLETMFQGSLHNQVPPMAVRALNKEL (1) 32512
VHLTPFLSEEAMNCLQTRWTDSAGTC (0)
TEWHDVSIPETVLALIAQMTTRALLGPALCRNPEWLDIAKSFTTNRAIAV 32193
32192 AAVQSWPSFLQPVIHWFLSPCRALRRQIQCARNILLPVLERERRSYRSDQPTKREFSNLA 32013
32012 FIDQYAKGARYDATMAQLRIIAVAFQTTSDLVEKVIARLCKHPELIQPLREEVVSVVGKN 31833
31832 GLHSHSLRKLTLMESVMKETQRLEPAVI (1)
IGMFRLAKE 31653
31652 KVTLKDGTVIPKGTNIAFANDLRFDPEMYPEPETFDGYRFQRMREDPEKIDLTPFTKTRM 31473
31472 SHLAFGHGKHACPGRFLACDEAKLILCHILLKYEIRAVEGSPPEL (1) 31338
31314 AGSWGNDVGEKAAGE* 31267
CYP5067A2 Aspergillus terreus
52% to CYP5067A1
see fungal pages for seq.
CYP5068A1 Aspergillus fumigatus
GenEMBL AAHF01000014
complement(618220..619713) no introns
locus_tag="Afu8g00740" fourth P450 of 8 on this accession
CYP65% to CYP5068A2
32% to 663A1 A. nidulans in the CYP64 clan
MELVAPTLLAIVLVCCCLHLLRSQ
ASRLPLPPGPTLLSRPFPEK
DIATTFQKWNQRYGPVISFRVGSRTFVVLGTRQAAQDLLEKRGSIYSSRPPSVWMEKY
LNKGLAAAFMPYGHEWRLNRRLHGSLLSAHHTNAYRSLQDIQSKQLLHDFLSTNDFSH
CFHQYTSNVMFTLVYGKGRGKDDNDHRRLEQINELAGFVLQGASFWTFLMDLFPILDY
VPRIFWKWRTEAARLHDRTMVVYRECCEEALTAECWHWSKEVTQKPDIMQLPWDNVCY
SLGELYVAGIHTTKMVLELCVMVSILYPDVVCKAQQELDSMVGADRLPSFDDMERLPF
INAIISELLRWRPISPIAVPHAAIQDDEYMGYFIPKGATVIANQFGMNMDDAFFYDPS
SFHPERYVENPDLPVSAFGFGRRACPGHRLARSSLFIVISRLLWAFHITSANKEPLTE
ESSPAAVKATFRVRSPHRQKIIERDWALAEKDERIVLSQIESRIRGK*
CYP5068A1 Neosartorya fischeri
92% to CYP5068A1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5068A2 Aspergillus oryzae RIB40
GenEMBL AP007155.1, BAE57974.1
complement(2295650..2297146) CYP65% to CYP5068A1
MELIIGLCLLAPLLFLYTPLRRFIGLN
2297065 ASELPLPPGPTLLSGPFPEKDIAKTFQKWNKKYGPIVSAKIGAQQFIILGSRRAAQDLLE 2296886
2296885 RRASIYSSRPASKFLDKYLHKGLASAFMPYGAQWRLHRRLGSSLLSERASTAYRQLQDFE 2296706
2296705 SKRLLHEFLSTNDFSEAFLSYTSDIMFTLVYGKGRGKDDSDHKMLYQINEMATFVLQKAS 2296526
2296525 FGTILLDLFPMLDWLPHCFLTWRKKAEELHYKTKEVYTECGNIALGGDCWNWSHEVSQRS 2296346
2296345 EAKELPWEDVCYALGELYVAGIHTTKMVLEILIMVCVLHKEVKQKAQAELDSVVGEDRLP 2296166
2296165 SPDDLEKLPYIRAIVSELLRWRPISPIGVPHAVIQDDEYMGYRIPAGATVVANQFGMNMD 2295986
2295985 EATFDNPAAFNPDRYLNNPDLPVSAFGFGRRICPGHRLARGSLLIVTSRLLWAYDITSAQ 2295806
2295805 GDADLGDEYSPSSVKAVFQPRSVKHEQVIKKEWEESDKDEKRILERIRDRI* 2295650
CYP5068A2 Aspergillus flavus
100% to CYP5068A2 Aspergillus oryzae
see fungal pages for seq.
CYP5068A3 Aspergillus clavatus
72% to CYP5068A1
see fungal pages for seq.
CYP5068B1 Aspergillus oryzae
GenEMBL BAE63024.1
39% to CYP5068A2, 41% to 5068A1
MVSYEWCLDSFNPFGITRNSLCFFFLVALCLCWSSSAWSSKQQRLPPGPPALPVIGNLHQMPRRNRWRAL
QRWHKLYGPIISLRLGQRIAISLGTHKVARELLELRGNNYSSRPRFVVAGDYVSEGLHSILLPYGNQWRI
HHRIQRELLTNHRTQAYRYLQDIESKQIVYDMLKSSDFVGHFRRYTSSVMFTLAYGKRLESPGRHEIAEA
SKITENISLAADQAKNMIVEVYPVLDYIPRCFAPWKRIGTRLHAQTVQFFEQQMLEGLRSPAWNWSKHII
ALNETKDLSNKEIVYILGALYEAGSETTATVLQIFVLASVLHPECIGHAQLELDESVGNDRMPTFEDMPR
LPYLNAFIKEVLRWRPIAPLGIPHAPSKIGEFMGYSIPEGATIFPNNWTLDLDDAVFRDPYAFKPERWLE
DPNLPLSTFGFGRRACPGKQMAENSLYIAIARLIWGYNFHHAYENGLRVELDPWDMKEGVVSPPATFSAV
LSVRSSVHQRLIELEWDSAEKDVNGILGQIESLMGSRAAAQKDSSA
CYP5068C1 Aspergillus niger
JGI gene model e_gw1.19.56.1|Aspni1
40% to CYP5068B1
see fungal pages for seq.
CYP5069A1 Aspergillus fumigatus Af293
GenEMBL XM_741366
41% to 5050A1 but only 34% to 5050B1, keep in a separate family.
O-methylsterigmatocystin oxidoreductase (ANNOTATION IN GENBANK ENTRY)
MDPFKAIDLPLPPHFVAALGRPTVLVGFACVFLFSQLLVWTAKY
SRKKSKGLADIPGPSGWPIIGIGLDLPARPRKLLNSWANQFGDTFKVRVGWYNWVFFN
HPDAVKEVFDRQAAVTSGKPPLPIAQEYCLRGDGVLPMTYNAKWKRLHAFLKQLLNAK
ASAAFIPSQEFEIKQLLWDLSHEAGKNSTDFYMHIRRMTFSIVMTSAYGLRIPQWDCQ
EVRDVYGNMRMLSIILSPGVFWIDVFPPLNWLPRFLFPSWPKAKFMAQKMHANKMRHW
NNLKERIALGNAPDCFAKDLMESNYRDYGLEEETVSWLASAVPEAGAETTASALNGMI
RYLAMFPEAQARAHEEVTRILGDGRMATLADEPQMPYIKAVIKETLRLCPVATTGLRR
MADGDVKYRDYVIPKGTILLANLNALHWDPERFPDPFSFKPERYLNHPHRSAVYAAGG
DIMARDHFTFGAGRRICPGIHLAENGLFLAVSNLIWAYEFKLPLDEKGNEIPLDISDE
GFMEGAIRVPKQYTVRILERNPARSRLIRESWEQAQKDGYILRGVHVDADGGVRGSAK
VKA*
CYP5069A1 Neosartorya fischeri
98% to CYP5069A1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5069A2 Aspergillus oryzae
GenEMBL BAE60165.1
76% to 5069A1
MDLYKAVVLDLHLSPGLISAIHKPTVLVGIACALFFSQLLFWTAKYSHKKTKGLADLPGPSGWPLIGMGL
DLPVRPRELLNRWAAQYGDVFKVRVGWYNWVFFNSPDAVKEVFDRQAAVTSGKPPLPIAQDYCLRGDGVL
PMTYNAKWKRLHAFLKQLLSAKASAAFIPSQEFEIKQLLADLSHEAGKNSTDFYMHIRRMTFSIVMTSAY
GLRIPKWDCQEVRDVYGNMRMLSIILSPGMFWID VFPPLNWLPRFLFPLWPKAKFMAN*MHSNK
MRHWDNLKDRITAGN
APDCFAKDLIESNHRD*GLEEETVSWL
ASAVPEAGPETTASALNGLIRYLAMFPDAQARAHDEVTRVLGDTRMATLADEPNMP YIRAVIKETL
RLCPVATTGLRRMADGDVHYRDHLIPKGTILLANLNTLHWDPERFPHPFHFKPERYLNHLHRSAVYAAGGDILARDNFFGAR
RICPGIHLAENGLFLAVANITWAYEFKLPLDDQGEEIPLDITDEGFMEGAIRVPKQYTVRILERNAARSR
LIRSEWDQAQQAGYVLRGSHVDVNGGVGGGSKTAAS
CYP5069A2P Aspergillus flavus
98% to CYP5069A2 Aspergillus oryzae
see fungal pages for seq.
CYP5070A1 Aspergillus oryzae RIB40
GenEMBL AP007157.1e, BAE58765.1
480458..482071 no introns
in the CYP56/547 clan about 33% to CYP617A1
MALFTFRLLPLVCTASIAIYVLSRFMHFETKSTGALTYSITFII
YLLYWLYIYPYHLSPLRHVPTVPGCPLWGHVFEIFNAEIGAVQQKWHKTHGPIVRYFY
PFGKEILSVVDNSALKHILVEASYNYEKTASNRKFLSRLFGEGILTAGGKVHAQQRKA
LNPAFSISAIKALAPAFWDYSCSMSSYWEQDIKESSDDSVSLDISDWASRATLDIIVA
VGFGAKIDTLHNSTAPLIEAFRTVFRFDAVAKLLAVLHILFPIVRYLPIKENREVDAA
KRTLFEFASGLIQEKEANINSTGNNILSQLVRGDRKPQAAGEDIFSRVICDQIATFLG
VGQDTSATWLSWTLHLLSKHQHMQVKLREEIRSHFPFLFRGATHEKIDFTEVDVDRLP
YLNNVCRESLRFIPPIPFVSREAARDERLGEYFIPKGTVIHIPINTIHRMPEYWGPNS
NAFDPDRWNCLPASYTNNAFLPFTQGPRGCIGRKFADTEVKTILCCLLSKFQFSPDPA
VQDPEELKRYRIVQKSQYGIRLKVSKLDG
CYP5070A1 Aspergillus flavus
99% to CYP5070A1 Aspergillus oryzae
see fungal pages for seq.
CYP5071A1 Fusarium graminearum (Gibberella zeae PH-1)
GenEMBL AACM01000117.1
52362-54017 (+) strand one intron
renamed, formerly CYP59B1
CYP5072A1X Ustialgo maydis
GenEMBL XM_757513
Same seq as CYP5030A1
CYP5073A1 Aspergillus nidulans
Name revised formerly CYP68M1
see fungal pages for seq.
CYP5074A1 Aspergillus fumigatus
GenEMBL AAHF01000006.1
40% to CYP68D2, 41% to 68A1, 42% to 68L1
may be a CYP68 new subfamily or a new family close to CYP68
join(2240366..2240617,2240858..2240960,2241166..2241768,
2241834..2242254,2243095..2243299,2243359..2243572,
2243792..2244367,2244427..2244655,2244889..2244922)
locus_tag="Afu6g13940"
gene model is wrong, two genes fused, missing exons
Part of a toxin biosynthesis cluster with another P450 CYP5281A1
and a PKS
43% to CYP68L2
MDSLALGSNWAGGVAIVLFLAPLALHLVSSY
LFPSTSTVINSGRAWDIFRTTAKKRFRSDAARLLQ NGFEK (0)
2240686 SPDAFRILTDNGPLLVLSPRYAREVRSDDRLSLDHFIAS (0) 2240802
2240858 EFHPDIPGFEPFKLILDPRNPLNTILKTSLTQAL (1) 2240959
AYMTEDLSVEVADALSTALTDDS (1)
EWHEISPCQTALKLVAQMASKAFIGPEKCRDPKWHNVIITYT
HNVYRAAQALHFWPKFLRPIVARFLPACQTLQAQIAEAREILEPLVAQRRADRACRAA
QGKPVPSRADVIDWLEDSHGDQPYDPVAAQLLLSFAAIHGTSNLLAQALMDLCTAPDL
IRDIRAEITSVLGDAGLTRAALYRLKLMDSALKESQRLAPNRL (1)
LSMGRIAQSDMHLSDGLRIPRGTTLMVSAHAMWEPQIYPDPRRYD
GYRFYKLRQVPGQEGQHQLVSATEKHMGFGYGKHACPGRFFAAAEIKVALCHILL
KYDLEHRGGGPPPRVWSQGIHLFPDPTARIRVRRRKEEISL*
CYP5074A1 Neosartorya fischeri
93% to CYP5074A1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5075A1 Aspergillus oryzae RIB40
GenEMBL AP007174.1, BAE65911.1
35% to CYP614A1 in the CYP534 clan
join(1244215..1244596,1244662..1245434,1245493..1245996)
1244215 MLLLLLETLALAYVAWSLVAMEINYRRACAMKIPLVRLCIDPQNLLWVILEPH 1244373
1244374 LWPWLDRLPINWGNFGRYSRRGWYFADRGESHRRYGPIWALVTPKEIYINVADSEAIHD 1244550
1244551 IFQRRTDFIRPVEQY (1) 1244595
1244661 TVLEVYGPCISTANTTDWPRHRKVLATPFNESVMSFVWDESVEQTRQMIDIWASPDLDKISS 1244846
1244847 VAKDTRTLSLNVLAAIGFRKSYPFRSGNGNSHREQSDSVSYRDALQTVLDNAILLMIMPR 1245026
1245027 RLLSLSFAPESWQQLAKAATDFKQHMVRMLDEEVQALNEGKAGSGGLMTSFVRAMNLKQ 1245203
1245204 EDARSKGLTTDEIFGNIFVINFAGHDTTANTLSFGLLLLAAYPEVQDWVAEELLLLTNTK 1245383
1245384 GQYADLFPKLNRCRAVM (0) 1245434
1245493 LETLRLYPPIPSLPKWTNDQAQPLKVGDRTIMIPPKVGINPSLLTMHIDPQHWEDPLEWK 1245672
1245673 PSRWITPTKLVRAISIEDEQLITPVRCTYFPWSDGPQNCPGNKFSQVEFVAVIASLFRHH 1245852
1245853 RISPVANAGETFQQTRERVLATTRDVDLQLLLRMKDAERVHLKCRRV* 1245996
CYP5075A1 Aspergillus flavus
99% to CYP5075A1 Aspergillus oryzae
see fungal pages for seq.
CYP5075A2 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_90633|Aspni1
72% to CYP5075A1
see fungal pages for seq.
CYP5075B1 Aspergillus oryzae
GenEMBL BAE58484.1
42% to CYP5075A1 missing C-term
revised 3/19/2009
MLLIIAVALLGWTLYSVFCLVGNIRRIQKIGIPYHVIPCSPVNPLWILLEPLIFFILGLLPFEFGRIKHY
GRRTWQFTDKAQSHMRMGDAWAIATPNEIFVYICDADAITDIIARRADFVRPIELFTLLNVFGPNVATTE
GADWQRHRKIVAAPFNESLNSFVWREALTQAQSMLTTRATAGPSGGLGTDTRTLALNVLAATGFKRSTRF
QSAQEAQSEDPRSYAQSLKTVMLNTFLIMLIPPSVLKFPIFPSWCRRAGEAVEDFKQHMLNMFNTEKTLL
DQGKPGTGTLMSSFVRESTVDPKSNKTVLTLDEILGNIYVINFAGHDTTAGSLTYVLFLLAAYPNIQEWI
AEEIRTVFPNPDRDTWDYKEAFPRLKRCLAVV (0)
LETVRLYPPILALPKSVAPQSTSLRLPESNRTIVLPKGTVVL
PSLLAAQTHPKYWPDEPTTWNPRRWIETSNPTDATTSTPEDHLAGEEIMEPRAGSYFPWS
AGVQNCAGRKFAQVEIVAAMAAWFREYRVRPVREDGEDFEKAQA
RILESTNDSYQLLVMQMRDPDSAKFVWEQVE*
CYP5075B1 Aspergillus flavus
99% to CYP5075B1 Aspergillus oryzae
see fungal pages for seq.
CYP5075C1 Metarhizium anisopliae var. acridum Ma102
CYP5075C1 Metarhizium anisopliae var. anisopliae Ma23
CYP5076A1 Aspergillus nidulans
formerly CYP670B1
MALSLNAAVVLAGVISHIAYFKQGEHHLYGFFYLKLLLTAMSTATVMLSY
VQGAPWRVALSTVLKLLSAYLFGIYTSLLVYRLLLHPLNRFPGPFPARIS
TVWTSTQLKSNNMHLTLLHYHRKYGPFVRIGSSDLSIAHPDALGPIYGTH
SRCIKGANYELSAPATALQLMRDPEEHHARRRVWSGAFSDRLLRGYEVRI
RKYREKLLDRLSEMSSRKEPVDVTKWFNLYSFDVMGDLSFGRGFEALERG
EEHWAMRLLMATQNFVGLNLPAWAFVLMIRIPGASMDFWRFLEFCGERLL
DRFKNDPEIPDISSSLFVPLKDRNVEDLTIEEKNLLYGDSRLIVIAGSTS
DTTAGTLSAIFYELVQHPEHITKLRDELEPHHLGNDNPKKTEFLHSKIAQ
LDHLNGVINEALRLYPAVPSSLQRKTPPEGVVVDGTYIPGDMHVVCPLYT
IGRSEIAYDHPEDFIPERWYSKPELVRHKGAFAPFSLGHFNCIGRPLALM
NLRVTLAQLIMEFDVKFAPGEDGKQFLADAKDNFVMYFGKLELAFTRRER
QKE*
CYP5076A2 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_200209|Aspni1
51% to CYP5076A1 (ferricrocin hydroxylase?, check for NRPS neighbor)
see fungal pages for seq.
CYP5076A3 Aspergillus terreus
57% to CYP5076A1
see fungal pages for seq.
CYP5076B1 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000168.1
formerly CYP670C1
41% to 670B1, 37% to 670A1 no introns
122339 MRLAHGGTAVVAGITAHLVYFHRGEHFGNGARYLSAFGFGVTILAGVRYTGENAGGYFECLAWALTM 122139
122138 AAYFLLGLYGSTLVYRLIFHPLNRFPGPLAARISDLWLCTQLGGHDMHHLSERLSKRYGE 121959
121958 FVRIGSSTLMLTHPKAVAAIYGPGSPCRKGTFYDLEQPNRGIATRDESLHAGRRR 121794
121793 VWSRGFGDKALRTYEPRVAAYVHMLLGRLADARGKPVDMARLAEAFAFDTMGDLGLGAD 121617
121616 FGMLRQARTHEAVEQLVQGMTIMGRRLPMWLMRLLIDVAQALVPTAATTGFLG 121458
121457 FCHHHLDRFMADPRRSERPSLMAPLLSHYEKQNIADRDLSILRNDCRFIIIAGSDT 121290
121289 VAATLTFAFFYLAKHPGHVTRLREELFPLRAADGTFSHQRIFDAPHLNAVINETLRLHPP 121110
121109 ASTIPRVTPPQGLVVADTFIPGDMTVFSSQYALGRSEAIYSKASDFIPERWCSRPDLIK 120933
120932 DGSAYAPFSIGHHSCLGRPLALMEMRLVLAETLSRFDIAFAPGFDANHFLQHVHDCMSWH 120753
120752 IGKLGLTFTAIE* 120714
CYP5076C1 Aspergillus oryzae RIB40
GenEMBL AP007151.1, BAE55487.1
formerly CYP5066A3
complement(join(1085860..1086053,1086107..1086208,
1086271..1086569,1086625..1086746,1086798..1087521,
1087687..1087712))
locus_tag="AO090005000422"
MDIKEKPTLYAFA
1087673 LGILIHILYFRIGEHHLYPARYIYGYFGSFIGVAAFLYLVEELPVHSASYRSLYL 1087509
1087508 IFTHLLGLYSSLVLYRLLYHPLRHFPGPFLSRVSVFWLSVQLRHKTLYRKLADLHNEYGD 1087329
1087328 FVRVGPSDLSIIHPKAVNTIYGFKSACTKSAWYDSSAPLRSLHSHRNRAAHDKHRRTWTP 1087149
1087148 GFTDRALHGYEKRIQVYRQKLINQIKSMEDSKPLNINTLFTWYGYDVMGDLAFGQSFDM 1086972
1086971 LVKSESHWAILMIHSMLKPMEYLMPIWFFRLLLSIPGTTKAFWKFNEYWGQLFKMRMA (0)1086798
TKQEIPDISACLLEPLKGRAPTPDEFNVLLGDASLIINAG (2) 1086627
1086568 DTTATTLTTIIYELARRPGEVQKLRTELVSCTTDPNGEYTQESLAILKHLNGVINETLRI 1086389
1086388 HSPVPSYIPRKTPPEGINIDGTHVPGNMNVSCPQWVIGR (2) 1086272
1086209 SESVYQNAQNFIPERWYLYPKMIKERSAFAPFTT (1) 1086108
1086054 GPYTCVGKPLALMNIRATIARLITTFDMELPPGDDGRALERSMREHFSI 1085908
YMAKDIQVHFQKRAI*
CYP5076C1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000263
Formerly CYP5066A3
99% to CYP5076C1 only 2 aa diffs
5507 MDIKEKPTLYAFALGILIHILYFRIGEHHLYPARYIYGYFGSFIGVAAFLYLVEELPVHS 5686
5687 ASYRSLYLIFTHLLGLYSSLVLYRLLYHPLRHFPGPFLSRVSVFWLSVQLRHKTLYRKLA 5866
5867 DLHNEYGDFVRVGPSDLSIIHPKAVNTIYGFKSACTKSAWYDSSAPLRSLHSHRNRAAHD 6046
6047 KHRRTWTPGFTDRALHGYEKRIQVYRQKLINQIKSMEDSKPVNINTLFTWYGYDVMGDLA 6226
6227 FGQSFDMLVKSESHWAILMIHSMLKPMEYLMPIWFFRLLLSIPGTTKAFWKFNEYWGQLFKMRMA (0) 6421
6473 TKQEIPDISACLLEPLKGRAPTPDEFNVLLGDASLIINAG (2)6592
6651 DTTATTLTTIIYELARRPGEVQKLRTELISCTTDPNGEYTQESLAILKH 6797
6798 LNGVINETLRIHSPVPSYIPRKTPPEGINIDGTHVPGNMNVSCPQWVIGR (1) 6946
7010 SESVYQNAQNFIPERWYLYPKMIKERSAFAPFTT (1) 7111
7165 GPYTCVGKPLALMNIRATIARLITTFDMELPPGDDGRALERSMREHFSIYMAKDIQVHFQKRAI* 7359
CYP5076C2 Aspergillus fumigatus
GenEMBL AAHF01000014
Formerly CYP5066A4
join(762752..763720,763784..763905,763978..764276,
764348..764487), gene model missing last exon
end of this predicted seq is wrong, replace with last exon
locus_tag="Afu8g00190" eighth P450 of 8 on this accession
51% to CYP5076C1, 43% to CYP5076A1, 34% to 670A1
MMPSVMKCGYLATAGLIGICTHLSYFRYGEHHLY
PWRYVRFHLCLTMGVAALLYAKKPPQYTLCSMDLVKDVSLLMATYLVGLFASLLLYRT
LFHPLRQIRGPWAAKISSFWLSFRLRRGPSFRILHELHEEYGPVVRVGPSEVSIIHPE
AVRMIYGPNSRCSKNTFYDNGHPMMSLHSYRDRIAHDQRRRVWSAGFGDRALRGYEQR
MRVYRQKLFQRLEARAVAESAINISQWFNFYSYDTMGDLAFARSFDMLDASRNHWAVD
MLMHGMIGYRYLFPSWFFRLLATMPSLSSDWHKFIGFATDTMLRRVGEQVDVPDIFAS
LLAPLNGREPTEDERNMLMGDAMLIITAGSDTTATSLTSIVYELARHLDEVDKLRAEL
DPIEADSDGEYQHDTLAKLPHLNGFINETLRLHPPIPGVIPRKTPPEGIHVKDVFIPG
NMTVFSPQWSMGRSEAAYIDPEIFNPERWYKHMDLVKDPSAFAPFSI (1)
GPYSCIGKPLALMNIRTTVARLIMSFDVRFPEGEDGIRWMDAADEHFAMGIHQMPVVLTRRH*
CYP5076C2 Neosartorya fischeri
92% to 5076C2 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5076C3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_5000548|Aspni1
57% to CYP5076C1
CYP5076D1 Aspergillus fumigatus Af293
GenEMBL XP_751878.1
52% to CYP5076A1An, 48% to 5076C1, 46% to 5076C2, 42% to 5076B1
note: duplication of KLR seq is missing in Neosartorya fischeri
MDSYVLIAIAGVLSHVVYFRRGEHQLYSHIYLVLFVISAAVVTVLVHYSYILVYLASLYTSILVYRLLLH
PLRSFPGPLAARVSGLWYIHPKHNAYLSLQALHSQYGPIVRTGPSDLSIIYPSAVPAIYGAQSACTKGPW
YDLSYPSRPLQHCRNAKEHHARRRTWTPAFSDRMVRGYEQRIQTYQQQLIAQLTARQTVDIRKWIYLYTF
DVMGDLSFGRSFDCLAAGHEHPGITLLNAALRNIGLFLPPWLHLILLKIPWLTRDWWAFQSFCSERLHAR
MRMDLPIPDISASLLAPLHGRAPTPEERLMLDGDARLIVVGGSDTTAVSLCGALYELARHPEQLRKLRKL
REEVEPFVDAAGDVRGADIALLEHLNGVINEALRMYPAVSSGLQRKTPPEGIQVEGVHIPGEMTVYCPQY
VLGRSELCYARPDEFIPERWYKYPGLIKDRSAFAPFSLGPYSCVGRPLALLNMRTTIAKLVTTFDMGFAP
GEDGKAFKQQAQDNFVLYMGPLHLTFARREGNWRRRSDG
CYP5076D1 Neosartorya fischeri
93% to CYP5076D1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5076D2 Aspergillus clavatus
AAKD03000015.1
61% to 5076D1
see fungal pages for seq.
CYP5076E1 Aspergillus niger
JGI gene model fgenesh1_pm.C_scaffold_3000040|Aspni1
44% to CYP5076C2
see fungal pages for seq.
CYP5076F1 Aspergillus terreus
49% to CYP5076C1
see fungal pages for seq.
CYP5077A1 Aspergillus nidulans
GenEMBL AACD01000108.1
Formerly = CYP532E1
revised to remove some intron seq
MAILVRLFFALFVVSVYFFRVRLRLSHIPGPFLASLTNINRRQWVTTGRA
HTIHTELHRQYGKVVRAGPNTVFVSDPAAIPAIYRFNEPYQK (0) SEFYDALMPYVRGKSIPDVFATRDEHIHRTMKQPIAAIYSMSNL
VSFEPYVKSTIEYFFSRLDSLFVETGKVCNFGLWLHLFASDVMGEITFSR
RLGFLETGGDMENVMANNWKFFVQAAPATQMPWLDYFWKRNPLLPGSVKP
NKVIEFGVARIQERLHL
SEKHPDHVNSRDFLSRFIAAKEKNSQIGPDAIM
TWANSNIQAGSDTTAILLSALFYHLLKNPTSLAALCTEIDAAAKRGCLSS
ILTWKETRDLPYLDACVKEAARLHPPISLPLERVIPESGTVIGGFKIPGG
TRVAMNPWAVHRDRDVFGADADTWRPERWLEGEEKAKTLYNSLLTFGGGH
RSCLGKNISYLEIYKLVPSILLRYEIGLAEPEKEWHLENRCCWTKLGTIR
LVSRFLG
CYP5077A2 Coccidioides immitis
56% to CYP5077A1 Aspergillus nidulans
see fungal pages for seq.
CYP5077B1 Aspergillus terreus
49% to CYP5077A1
see fungal pages for seq.
CYP5078A1 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_24000135
Necha1/scaffold_24:345480-347594
57% to CYP5078A2 probable ortholog
see fungal pages for seq.
formerly CYP532C3
CYP5078A2 Fusarium graminearum
formerly CYP532C1
see fungal pages for seq.
CYP5078A3 Aspergillus nidulans
formerly CYP532C2
see fungal pages for seq.
CYP5078A4 Aspergillus fumigatus Af293
GenEMBL XP_748665.1 also EAL86627.1
72% to 5078A3
MEVSILSLFKAYAAYVTVAVVLLRLITNRFRRGLAGIPGPTIAKWTRLWKLHSVWKGNHHTTAIDLHRKY
GPLVRIGPKHVSVGDPSAIPIIYGLNKGFTK
TGFYPIQCISWNKRPQMNLFSTRDEMFHREQKRPVANAYSMTSLLELEPAVDSCT
EIFINQLARFANSKKPVDLGMWLQYYAFDVVGEFTFAKKLGFLQEGKDVDGMIEAIQGMLVYASVCGQIP
EAHPLLLGNPLFPIFMPSMETWNQVLNFTLKAINSRASLQRDGELDAEKPEAGKDMLSRWMAIHLSDPEK
LTTRDVIVHLSTNVFAGSDTTAIALRAVFYFLLRNPSVLAKLNAEIDNADREGKLSTPISYRETMNHLPY
LQAVLKESMRLHPSVGLILEREVPKGGVTICDRHFPGGTIVGINAWVLHRDARVFPDPDKFIPERWIDSD
PQHLKKMDQSFFAFGAGSRTCIGKNISLIEMHKIIPQLLREFEIRLHSPEKEWKTKNVWFVQQEGLVCDL
VCRRDAKCYH
CYP5078A4 Neosartorya fischeri NRRL 181
DS027697
complement(join(1475691..1476929,1476977..1477279))
93% to CYP5078A4 = ortholog, 75% to 5078A1
note name changed from CYP5078A6
MEVSILSSFKAYAAYVVIAVVVLRLITNRFRRSLAGIPGPAIAK
WTRLWKLHSVWKGDHHTTAIDLHRKYGPLVRIGPKHVSVGDPSAIPIIYGLNKGFTKT
GFYPIQCISWNKKPQMNLFSTRDEMFHREQKRPVANAYSMTSLLELESAVDSCTEIFI
NQLARFANSKKSVDLGMWLQYYAFDVVGEFTFAKKLGFLQEGKDVDGMIEAIQGMLVY
ASVCGQIPEAHPLLLGNPLFPIFMPSMETWNQVLNFTLKAINSRASLQRDGELDAEKP
EAGKDMLSRWMAIHVSDPEKLTTRDVIVHLSTNVFAGSDTTAIALRAVFYLLLRNPSV
LAKLNAEIDNADREGKLSHPISYRESMNHLPYLQAVLKEAMRLHPSVGLILEREVPKG
GVTICDRHFPDGTIVGINAWVLHRDARVFPDPDKFIPERWIDSDPQHLKKMEQSFFAF
GAGSRTCIGKNISLIEMHKIIPQLLREFEIRLHSPEKEWKTKNVWFVQQEGLVCDLVR
RRDVK
CYP5078A5 Aspergillus oryzae
GenEMBL BAE65602.1
66% to CYP5078A3
MIDAASVVILIIGLIVARLVTNRFRLSGIPGPSLAAYTRLWKLYNAWKGDHHHTEIALHRKYGSLVRIGP
RHISVSDPKAIPIIYGVNKGFTKTAFYPIQSISWDKKPQMNLFSTRDELFHRDRKRPIASAYSMTSILEM
EPAVDSYTELFLSQIRKMVEEKAPIDLGMWLQYYAFDVVGELSFAQKLGFLEKGEDVDNMIEAIRGMLTY
AMICGQIPEAHKVLLGNPLFPILLPQMETWDQVVVFTLKAINRRASLQRDGDLGKDEIDEAIGGKDMMSR
WLAIHNADPTRLSTRDLMVHLSANVFAGSDTTAIALRSILYHLICHPDKMAKVRAEIDTADQEGKLSNPI
SYQESNTHLPYFGAVMKEAMRLHPSVGGNLERHVPPQGVTICGHYIPGGTNVGINPWVVHRDPIVFPQPD
SFIPERWLDSTPEQLKEMEKAFLNFGAGSRSCIGKAISLMEMRKILPQLLREFDIHLHQNKSWKTRNVWF
VQQEEFICDLTPRVRS
CYP5078A5 Aspergillus flavus
99% to CYP5078A5 Aspergillus oryzae
see fungal pages for seq.
CYP5078A6P Aspergillus clavatus
AAKD03000012.1
pseudogene 74-85% to CYP5078A4
see fungal pages for seq.
CYP5078A7 Mycosphaerella graminicola
64% to CYP5078A2 Fusarium graminearum
see fungal pages for seq.
CYP5078A8 Fusarium verticillioides
77% to CYP5078A2 Fusarium graminearum
not found in the F. oxysporum genome
see fungal pages for seq.
CYP5078A9 Aspergillus terreus
73% to 5078A4
see fungal pages for seq.
CYP5078B1 Mycosphaerella graminicola
46% to CYP5078A4 Aspergillus fumigatus
N-term from JGI model e_gw1.1.657.1|Mycgr3
see fungal pages for seq.
CYP5078B2 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_12420
63% to CYP5078B1 Mycosphaerella graminicola
53% to CYP5078A1
C-term is from EST, this region is gapped in the genomic seq.
see fungal pages for seq.
CYP5078C1 Histoplasma capsulatum G217B
44% to CYP5078A3, 41% to CYP5078B1
see fungal pages for seq.
CYP5078C2 Aspergillus terreus
57% to CYP5078C1 Histoplasma capsulatum
see fungal pages for seq.
CYP5078D1P Mycosphaerella fijiensis
JGI gene model gw1.2.1437.1
47% to CYP5078B2 Mycosphaerella fijiensis
see fungal pages for seq.
CYP5079A1X Ustilago maydis
GenEMBL XM_753249
named CYP5079A1 by accident
same as CYP5028A1, use earlier name
CYP5080A1 Fusarium graminearum
AACM01000150 FGcontig1.150_scaffold2
formerly CYP532B1
see fungal pages for seq.
CYP5080A2 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_7000447
Necha1/scaffold_7:1257355-1258984
75% to CYP5080A1 probable ortholog
see fungal pages for seq.
formerly CYP532B4
CYP5080A3 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_234000002 short at
55aa gap near C-term
Necha1/scaffold_234:7436-8694
54% to CYP5080A1, 59% to 5080A2
see fungal pages for seq.
formerly CYP532B5
CYP5080A4 Fusarium graminearum
AACM01000323 FGcontig1.323_scaffold5
formerly CYP532B2
see fungal pages for seq.
CYP5080A5 Nectria haematococca (Fusarium solani group)
JGI gene model fgenesh1_pg.scaffold_9000319
Necha1/scaffold_9:1041947-1043927
52% to CYP5080A4 possible ortholog
see fungal pages for seq.
formerly CYP532B3
CYP5080A6 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.1.1091.1
Necha1/scaffold_1:3107512-3109250
50% to CYP5080A1
see fungal pages for seq.
formerly CYP532B6
CYP5080A7 Fusarium oxysporum
80% to CYP5080A2
see fungal pages for seq.
CYP5080A8 Fusarium oxysporum
58% to CYP5080A2
see fungal pages for seq.
CYP5080B1 Aspergillus nidulans
40% to 532A1 49% to 532B1 53 clan
formerly CYP532F1
see fungal pages for seq.
CYP5080B2 Aspergillus oryzae = CYP5080B2
GenEMBL AP007164.1f, BAE62337.1
sixth P450 of six on this accession
CDS join(1717617..1717983,1718066..1718266,1718322..1719073,
1719123..1719320)
52% to CYP5080A2
72% to CYP5080B1
formerly CYP532F2
MYILLLLPVLIVSYHVLHLIYITLTTKSLLSVPGPFIARLTKLWYFDRVRRGHFEEDNVRLHERYGPVVR
IAPDHYSISDRAAVKLVYGTGTKFTKSAWYEGWKHPSPERWTLFPDRDVRRHAETRKRFSGLYSMSSLVH
YEEFVDHCADIFSQRLTEYAQREGSLNLGHWFQCYAFDVIGEITFGKRFGFLDQGDDIEGTIAALQKTMV
YSTLIGIYPEWHPRLFELLSHFSWSGAGGRTYIMRYVQEKIRRHSEPAKRDPEQGTLQTQDFLEKMILAR
DKDPEKVTDYHLFMMGLSNVIAGSDTTAISLSSIMYHLLHYPAVLEKLRREVDDFTAQGRCSARVTFKES
QEMPYFQAVMKEALRMHSATGLPLWRVVPAGGAEISGYYFPEGTTVGINTWVAHYDEEIYPDAKKFRPER
WIEAEADPERLKIMNEMYMPFGLGSRTCLGKHISILEMSKMIPRLIRDFDFTTTSQKWSTENYWFVKPTD
FVVKVRRRTSSAKQA
CYP5080B2 Aspergillus flavus
100% to CYP5080B2 Aspergillus oryzae
see fungal pages for seq.
CYP5080B3 Aspergillus fumigatus Af293
GenEMBL XP_753882.1 also EAL91844.1
71% to CYP5080B2, revised at C-term 3/12/2009
MFLIIVIPIVILLYPFLSTLYTTLRTRSLRRIPGPFLTRLTKLWYFYRVRAGHFETDNIALHRRYGPVVR
IAPDHYSISGSAAIKTVYGTGSKFTKSAWYEGWKHPDPNQWTLFPDRNIKRHAETRKRFSSLYSMTSLVH
YEAFVDRCADLFCMRLREFAARGEEFNLGHWFQCYAFDVIGDITYGQRFGFLDRGEDIEGTIAALQRLMT
YSTLVGIYPEWHPRLFGPLSRFSWSGAAGRAYIVRFVQEKIRGLSVKADPGQVERGPLATQNFVEKMMLA
RDKDPEKVTDYHVFMMGLSNVIAGSDTTAISLSAIMYHLLRYPAVMEKLRREIDAFAADGKCSDSVTFRE
SQEMPYFQAVIKEALRMHSATGLPLWRVVPDGGVEINGYFFPAGTVVGINTWVAHYDEEVFPDATTFRPE
RWIEAESNPEKLRAMNEMYMP (0)
FGLGTRTCLGKHISILEMSKLIPRIVRDFDFSTRNENWETENRWFVKPTNFTVRVKQRPVAGGTKVTA*
CYP5080B3 Neosartorya fischeri
95% to CYP5080B3 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5080B4 Aspergillus terreus
80% to CYP5080B2
see fungal pages for seq.
CYP5080B5 Metarhizium anisopliae var. acridum Ma102
CYP5080B5 Metarhizium anisopliae var. anisopliae Ma23
CYP5080C1 Nectria haematococca (Fusarium solani group)
JGI gene model e_gw1.6.751.1 with modifications from gw1.6.1186.1
Necha1/scaffold_6:2410473-2412365
44% to CYP5080A4, 62% to 5080C2
see fungal pages for seq.
formerly CYP532G1
CYP5080C2 Nectria haematococca (Fusarium solani group)
JGI gene model gw1.13.252.1 short on N-term and C-term
Necha1/scaffold_13:992678-994370
62% to CYP5080C1
see fungal pages for seq.
formerly CYP532G2
CYP5080D1 Aspergillus nidulans
formerly CYP532D1
AN5553.1
43% to 532B2 53 clan
revised 7/19/07
MLSSLLSLPAILSFFLALCIIQLVRSLAKSPYGSIPGPALARFTNAWYLW
QMRRGDFHRTNIKLHQQNGPVVRIAPEYFSISDPSAVKPVYGHGTKFIKS
EWYKAWNVTPDPDQTNLFSEQVSQRHAENRRKVASMYSMSSLVAYEPYVD
NCIAVFKQRLNEISVQGKTVDMAHWLQCYAFDVIGEITFGSRFGFLDAGN
DVGGVMKSIEDGLAASSYLGLYPWIYPFYLRVLGYLRQGLSYMNEFSLLH
IQETRAAMKGSHKDLPSYMAVKLVQAQTENPHRISDWDILATVGANVGAG
SDTTAISLSSTLYHLYRNPGCLAKLREEIESAGIGTVIPAFKSTQEMLYL
QAVLKEALRVHPGTGFPLFRVVPKGGQVLAGQFFPGGVNVGINSWVLHYD
TNIYGADASIFRPERWLEADEEQLKTMEQNYMPFGIGSRTCLGKNISLLE
MGKLIPVLVRDYDFDIQGEGDLEARNRW
FVKPVDFWIKVTKK
CYP5080D2P Aspergillus niger
gw1.11.656.1|Aspni1
52% to CYP5080D1, frameshift and deletion before PERW
see fungal pages for seq.
CYP5080D3 Aspergillus clavatus
61% to CYP5080D1
see fungal pages for seq.
CYP5080E1 Aspergillus oryzae
GenEMBL BAE63486.1
42% to CYP5080B1, 41% to 57A3, 42% to 57B2
42% to 5038A1, 43% to CYP5080C2, 43% to 5080C1
in the CYP53 clan part B
MNDERIVLTQDKGQSYTAQLLYLIVAGYIAHTVYYAYWGPTARIQGPWLARFTRLWELLKVSKGHFEQVN
IDLHKKYGPIVRISPNTFSISDPSAIKQIYLGRTTLMKSKFYEPFGDPLDPNLFSETDIKKHAQSRKAVA
HLYSMSFLVTYEGSADRCNVQLCAKLRDFARHRTAFDVPTWMQFYAHDVIGEITFGEPFGMMAKGQDEHG
IADSIDETIAYASRMAVIPELHRWVSWFGRVAHLKTPFHNIQKYILEQIDSRSGSDSVGIDFLKKLLTLR
EDDKITQLDIEKTVGNNIMAGADTTAISLSAVIYSLLKNPGTETKLREDIDTLAAAGKLSNPVTFEQARH
MPYLQACIKEALRVHPAVGRPLLRVVSPEGLTIAGQYFPGRFQGNSRYQCLVAHYNEDIFGRDATTFRPE
RWLESDKEKLSVMEQSLLAFGAGVRTCIGKNLSMLEMSKVIPELYRQFEFELSESEGAWMTWNNWFVKPA
FECYVRLREGV
CYP5080E1 Aspergillus flavus
98% to CYP5080E1 Aspergillus oryzae
see fungal pages for seq.
CYP5080F1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_7000061|Aspni1
50% to CYP5080D1
see fungal pages for seq.
CYP5080G1 Mycosphaerella graminicola
48% to CYP5080B2 Aspergillus oryzae, top 13 hits are CYP5080s
see fungal pages for seq.
CYP5080G2P Mycosphaerella fijiensis
JGI gene model fgenesh1_pm.C_scaffold_27000021
53% to CYP5080G1 Mycosphaerella graminicola
see fungal pages for seq.
CYP5080H1 Mycosphaerella graminicola
JGI model estExt_Genewise1Plus.C_chr_31342|Mycgr3
44% to CYP5080B2 Aspergillus oryzae,
44% to CYP57B2 Nectria haematococca, these two families overlap
see fungal pages for seq.
CYP5080J1 Coccidioides immitis
52% to CYP5080B2 Aspergillus oryzae
see fungal pages for seq.
CYP5080K1 Fusarium oxysporum
49% to CYP5080J1 Coccidioides immitis
see fungal pages for seq.
CYP5080L1P Fusarium oxysporum
47% to CYP5080C1, EXXR motif missing
see fungal pages for seq.
CYP5080L1 Fusarium verticillioides
88% to CYP5080L1P Fusarium oxysporum = ortholog
CYP5080M1 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_22000072
46% to CYP5080J1 Coccidioides immitis
43% to CYP5080L1 Fusarium verticillioides
see fungal pages for seq.
CYP5081A1 Aspergillus fumigatus Af293
GenEMBL XP_751355.1 also EAL89317.1
50% to CYP5081B1, 46% to CYP5081C1, 43% to CYP5081D1
MRTYAIRPVSNRLPGPIEPKKHRRDRDNSTTGSLYNALIHPVQGEKTITSTMIRVAEFQPFLNTISVLQV
LAAIFIGALTYRLIDAFFLSPLRSIPGPLLARLTTKRANVDTFSGKVTQTVDKDVARYGDVYVYKPRAVC
INHPDDIRAVLGSQEFRKAAFFDIFNDGNTPNIVSLREPELANRRRRQLGPFFNYAYLGRAEPLILQHGY
QAIRTKWDALIQANSGRPTEVNYRTDTQLVTFDIMSALAFGRNFNAISRGSSSIMKWAGLIMEMLESPAV
LALLSLLPFSLIMRPWKIMYRELAAFSSDAVDMRKQLLAEDSTEKPLDMLQAFIDAEDPESKIKMSPHEV
QAESIMMMLAGSETTSSAIMWTFHLLLLYPETLRRAVHEVRSAFSLNHLVTYKDVRSSLPYVEACVYEAL
RHSPTTAGLTPRISHSTGITLQGYYIPPGTEIYVNLRSPSMHPSLWDDPARFNPDRFLDSDNNKRLLFTF
SYGPRNCLGRNLAWVEMLTIVANVLKDYDIALTEDSLFGPHCTDENGLPVLMPAKCFIASFPAKPERDCR
MVITRRMAGVKACAREYSPC
CYP5081A1 Neosartorya fischeri
97% to CYP5081A1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5081A2 Metarhizium anisopliae var. anisopliae Ma23
CYP5081B1 Aspergillus fumigatus Af293
GenEMBL XP_751354.1 also EAL89316.1
50% to CYP5081A1, 50% to CYP5081C1, 43% to CYP5081D1
MALPIILCLAVILWTSWRLLDALFLSPLHRVPGPVLARLTPLRAIYARLPSRVIPAALADFHSYGDIYLS
KPRTITISHPRDVRAILASSEFQKIDVYHGLNDPVMANIVTFSDPKLASRRRRQIGPYFNPSYLAKMEEL
ILRCGCRAVADKWGRLIAQQGHGPQKSVKVNYRHDLQLATFDIMSALAFGRWLDSLKEEGESVAIVEWIM
ATAVYIGVRINFRLLMVFPFSRLVRRWTRAYAEFVQFSKHAVASRKELLAQGCQKPVDLLQAFIDAEDPD
SKVKMTTVEVQAESVGMQLAGSETTAASLTWAVHLFTLYPEYYRIAVDEVRGQFGPNHLITYADCSRLVF
LEAFVYEMLRYTPITSSFMPRVSFTKGTTLQGHYIPPGTEIAFNLIAMNNREDVWEEPERFLPDRFLKDP
DLKRSVFAFSYGTRSCIGRHLAWMEMMTILANLLKDYDWSLPEDSLYGPHHVDEKGIPIRMPSKCHIVFA
PTHPDRDCQLVISRPKT
CYP5081B1 Neosartorya fischeri
95% to CYP5081B1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5081B2 Metarhizium anisopliae var. anisopliae Ma23
CYP5081C1 Aspergillus fumigatus Af293
GenEMBL XP_751350.1 also EAL89312.1
50% to CYP5081B1, 46% to CYP5081A1, 45% to CYP5081D1
MVEILRFIPLVLLLTLTWRITYELFFSPLRHIPGSLLARLSSKYSILKRVLSDGPQSVQADYQYYGNIYV
HRPNGVSISHPDDIRTVLLSPEFRKTKVYEMLDIEGHASIFTTRDPAQASRRRRQIGPYLNHGYLGRMEG
LIMKYSVLAIKRKWDRLLEESGGQQVTVNYRDHKQYATFDTIGALAFGREFNALTNDDRTVIRWIEATGL
YLGIRKNFPLLKLWPFSRVLRQYRERYERFIAYSKESVTRRKNLLSTVGERPMDLLQAFIDAEDPENPHV
KMTADEVMTESIAMQLAGSESTSFVTSWVIHLLTLYPQHLAKVTEEIRSQFSPSHLITFAECRDKLPYLE
ACVYETLRYSPITSGFLPRISYTKGLTIQGHYIPPGVEIAINLHGAHINKDVWTNPHLYDPTRFLGDDQA
KRNVFAFSYGHRNCIGRNLAMMEIMIIIANILKEYDIALPEDSVHGPWNVDALGRPRIMPTRSALFTTPK
YPERDCRLVVSRRQ
CYP5081C1 Neosartorya fischeri
95% to CYP5081C1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5081C2 Metarhizium anisopliae var. anisopliae Ma23
CYP5081D1 Aspergillus fumigatus Af293
GenEMBL XP_751352.1 also EAL89314.1
45% to CYP5081C1, 43% to CYP5081B1, 43% to CYP5081A1
MQKACRGHRTAIFRILISLFPFTTLCSSLVGPETQSLHDTMAVATLISILFAVLALRLCYLLIHALFLSP
LRHIPAPFMARVTSKRPLWHLLTGKAEIAARQDYSTFGDIYLCKPNTVYLCDPHDACTVLSSHAFRKTDM
YRVFEYEGIPNVSTFTDPAQAQRRRRQLHPFFNNAYLTQMEPVMLKYGIQALKARWDAQLARHKKVEVNY
RFDTQLAMFDITGALVFGREFHALETSNLVYTKWVNNTLSYMLVSHYFPWVKRVPLSWLVRGLKQSYDDL
VAFSQESIAIRQADLQAGRPKPADLLQALLDAEDPDSKAPMTAREVQAESIAMLVGGSESTSSVISWVIH
FLLLYPEHLQAVVAETRANFPADHTITFNESKANLPYLEACIYETLRCIPTASTSFPRVSDQAIILKGYY
IPAGTEIATNKCAAHLHQPSWQDPDRFYPPRFLNQETYHETRRNMLSFAYGTRFCIGRNLAWAVMMVTLA
NLFKDYEVELPEDSRFGPTIVDAAGRPKIMPTKMGVATMPADPERDCRMVLSVRITE
CYP5081D1 Neosartorya fischeri
95% to CYP5081D1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5082A1 Aspergillus fumigatus Af293
GenEMBL EAL92287.1 also AAHF01000002.1
94% to Neosartorya fischeri CYP5082A2
86% to Aspergillus terreus CYP5082A3,
44% to Leptosphaeria maculans CYP5082B1
35% to CYP686A1P
MDSAQPTKLDFLTVPATPFSIGGLASIVVLVTVVIGPKAVIDTVLN (0)
SYLSLVHRIPAADGKKYMSGPAYTFPNGQMVDKFLAARTRSWEWEEKYGKTYRIWAASIPEV (2)
633544 VITDPKDVEVLYQQSTDHNKAPQANAGWLLTQLLGSGLGLINGTRWSTLRKTLDPMFSHR 633723
633724 AALQYLRDSLDAGAQDYVAGIHQFAKADGQVQTADGKVMVINATQALQRYPFFEVASMFY 633903
633904 GKMSEAEHERLWDLGRRYSEVFAAIVSGGIHRSKLTRY 634017
LNTKAWNNARDYQKAWRDFNREIYTARKMTAPDTPIVALTEAAERGELTPNE (0)
VTDTIAESTFANLD
IVTHVISSCIILLADSPEVQNDLLQEMEKNKADRENYITRKDTLLHYCLLESLRLRPVL (1)
SFTFPENPPREKILGNFVVPKDTTIIVDAFAINIRNPFWGPDNRAYRPSRFAGIKQSQLRYNLATFGYGP
RKCLGQHIADKIVKAVVYHLFSKYRVSLMPMQAVEGDFKVDKTSWVALYDVDLKLEPRES*
CYP5082A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000007.1
94% to CYP5082A1 Aspergillus fumigatus = ortholog
name revised from CYP5082A2
MDSAQPTKLDFLAVPVTPFSIGVLASIVVLVAVLIGPKVVIDTILN (0)
GYLSLVHRIPAANGKKYMSGPAYTFPNGQMVDKFLAARTRSWEWEEKYGKTYRIWAASIPEV (2)
602792 VITDPKDVEVLYQQSTDHNKAPQANAGWLLTQLLGSGLGLINGTRWTTLRKTLDPMFSHR 602971
602972 TALRYFRDSLDAGAQDYVAGIHRFAKADGQMQNADGKGIIINATQALQRYPFFEVASMFY 603151
603152 GKMSEGEQERLWDLGRRYSEVFAAVVSGGIHRSKLTRY 603265
LNTKAWNNARDYQKA
WLDFNREIYTARKMTAPDTPIVVLTEAAERGELTPNE (0)
VTDTIAESTFANLDIVTHVISSCIILLADSPEVQNDLIQEMEKNKADREDYITRKDTLLHYCL
LESLRLRPVL (1)
TFTFPENPPREKILGNFVIPKDTTIIVDAFAINIRNPFWGPDNRAYRPSRFAGIKQSQ (0)
LRYNLATFGYGPRKCLGQHIADKIIKAVVYHMFSKYRVSLMP
MQAVEGDFKVDKTSWVALYDVDLKLEPRES*
CYP5082A3 Aspergillus terreus NIH2624
GenEMBL AAJN01000207.1
MDHAQPTKLGFLAVPAAPYSIGILVFVLVVLAAIGPWAVVDSILN (0)
CYLSFVHRIPAADGKKYISGPAYTFPNGQMVDKFLDARTKSWEWEEKYGKTYRIWAASIPEV (2)
337559 VITDPKDVETLYQQSTDHNKAPQANAGWLLTQLLGSGLGLINGTRWTSLRKTLDPMFSHR 337380
337379 TSLQYFSDSLDAGAENYVAGIHQFAKADQVCADGKSIILNATQALQRYPFFEVASMFY 337206
337205 GKMSEEEQERLWVLGRRYSEVFAAIVSGGIHRSKLTRY 337092
LNTKAWNNARDYQTAWREFNREIYKRRKLTAS
EAPIVVLTEAAERGELTYNE (0)
VTDTIAESTFANLDIVTHVISSCIILLADAPEVQKDLLQEMNRNKADRKAYITRKDTLLHYCLLESLRLRPVL (1)
SFTFPENPPREKVLGNFVIPKDTTVIVDAFAINIR
NPFWGPDNRAYRPQRFAGIKQNQ (0)
LRYNLATFGYGPRKCLGQHIADKIIKAVVYHLFTHYKVSLQPMQAIEGDFKVDKTSWVGL
YDVDLKLDPRGPCVDKVDV*
CYP5082B1 Leptosphaeria maculans
GenEMBL AY553235.1
sirodesmin biosynthetic gene cluster, SirC gene
note: a second P450 SirB exists in this gene cluster
Sir B = CYP5093A1
MESIVYETQPLLRGMVVGTIMLLC
37766 YRYGLALSILQVKHPLAMINFVQSLLIQMKLYLNFMYRITNEKGKPLRGPEFSWPDGQT 37590
37589 VEKFLQGGQKSFSWQAYGPLYRIWTVFRPEV (2)
VITRPEDV 37413
37412 KAFFFDSHTHQKAASSNAGWLFSQILGDCLGLINGERWSRVRHAFDPFFTRKISAQRLPH 37233
37232 IMAAGEGYVNEVHQYDLGGKQAASTINLNAVDAFQRFPFFYVAEIIYGPLGITERVE 37062
37061 LWKLAETHTNIFRRLVQGGIHRYKATKFLSTSAYKETAHFVAAWRQFTLELAQKQLREGR 36882
36881 TSPLTDLMAEVEDGKVTLNE (0)
36745 VLHTIDESLFANLDVTTHVLTWAIVLLGNHPDVQELVRSEIKANTNDLETYMNRKDTLL 36569
36568 HYSLLESLRVRPLL (1) 36527
36474 AFTIPESAQEDKVLSGYRVPKN (0)
TDVVVDVNALHLRNPFWG 36301
36300 ADRMQYRPQRFQVLSKAE (0)
IRYNLSTFGFGPRKCLGQHMAEN 36121
36120 MIKAILVPLLRQFRFKLLADQYKNGEYKVDKTNWVTLSDVNLEMERVPSGGS* 35962
CYP5083A1 Aspergillus fumigatus Af293
GenEMBL XP_754165.1 also EAL92127.1
AAHF01000002.1
MEAVIV (0)
205012 ASGLCVAYAVYYVYSDALAEVPGPRFAKICP (0) 205089
SWLIRVLWSNKLNQGIREQHQKHGKPSMPFPSTSFTRSDKLTEHKGDVVRLGPSELSFCSLSAH
DTIYNTNSTSFITYGSFQSAVEGLCPPGVTFVSHHSPAEQKELRRVFQPAIRLAVAGGMEAHHKRRFSEL
VAGLNIKPGVPICVNLTGLLERLEWDLIGDLGLGYSVPDRLKDNWNSQKTHQNLIGVAFALGSFLLSRRG
LKMLVDSFGPFWIPKYLDPAHLIDVALKQRAEGKSTFVSQAIPYKNEKYPHLTKQMSSNVTGLIYAAFET
SESSTRAILCALMRDPVRYRNLQQEIRSKFSASKPITDSQLVGLPYLTACINEGLRLWPGLNGQFTSRVS
TGAVVDGVYVPPGCLVSADLYTLQRHPRYWHDPDTFKPERWLDPKNPDEMRAFRPFSAGPRSCPGRQIAL
QKLRLTLAKFMFLFDMQFVNPQFEWDRDVPSGLLWSSVEVMVRMTLLEPPVEPAEAVETAEAVEA
CYP5083A1 Neosartorya fischeri NRRL 181
NZ_AAKE03000007, NFIA_062670 revised
95% to CYP5083A1 Aspergillus fumigatus = ortholog
~30 kb from PKS, 96% to 5083A1 probable ortholog
NAME REVISIED FOM CYP5083A2
MEAVIV (0)
ASGLCVAYAVYYVYSDALAEVPGPGFAKLCP (0)
SWLIRVLWSNKLNQGIREQHQKHGKPS
MPFSSNSFDRSDKLTGDKGDVVRLGPSELSFCSLSAHDTIYNTNSTSFITYGSFQSAVEGLCPPGVTFVSHHSPAEQKEL
RRVFQPAIRLAVAGGMEAHHERRFNELVAGLNIKPGVPICVNLTGLLEKLEWDLIGDLGLGYSVPDRLK
137863 DNWTSQKAHQNLIGVAFALGSFLLSRRGLKVLVDSFGPFWIPKYLDPAHLFDV 138021
138022 ALKQ
RAEGKSTFVSQAIPYKNEKYPYLTKQMSSNVTGLI
138244 YAAFETSESSTRAILCALMRDPVRYRTLQQEIRSNFSA 138357
138358 SKPITDSQLVGLPYLTACINEGLRLWPGLNGQFTSRVSTGAVVDGVYVPPG (0) 138510
138606 CLVSADLYTLQRHPRYWHDPDIFKPERWLDPKNPDEMRAFRPFSAGPRSCPGRQ 138767
138768 IALQKLRLTLAKFMFLFD 138821
MHFVNPHFEWDRDVPSGLLWSSVEVMVRMTLLEPPVEAVEAAEAVEA
CYP5083A3 Aspergillus clavatus
AAKD03000004.1
59% to CYP5083A1
see fungal pages for seq.
CYP5084A1X Aspergillus fumigatus Af293
GenEMBL XP_751310.1 also EAL89272.1
Gene modle short needs revision
Name changed to CYP5121A2
MSLTNGCFCGFAIDSLRIRRYPVELYPAKHTPRPVACGSGRRRSASLTPPSSSGWMPPALKGRSDHRIYL
DEQTDDGPQHHDEIKNLVLNFLRAIRRQHTMKLTVFRNFATDIVGRMFVGDLGDDRAAPIGTRSNHIDRC
RFTTSLDHIMFKSPVAKLKRKRNKGLRWISCAGTYSRWNDASIVDVLPETGRKTILQAETREYDGPYDSL
IVNGADCMAAAFVSMFRHLFKCPTAMFQLQDEVDNAFRNLTISDVLHQETELHALPFLDAVMKESMRLAM
KFDYRRAVPAGGLAVLGHYVPERTVVQFHSEALRNNRTTFGEDVSDFRPQRWLQADLDQWQRTRMEEALL
FLRPNIPNSAEARAAWLELKRAAALIIWKFDLHPLNYEEVFIQDAVSPEQEYEIMVNFTPRMH
CYP5085A1 Aspergillus fumigatus Af293
GenEMBL XP_750862.1 also EAL88824.1
GenPept AAW03300.1 GliF
Gardiner,D.M. and Howlett,B.J.
Bioinformatic and expression analysis of the putative gliotoxin
biosynthetic gene cluster of Aspergillus fumigatus
FEMS Microbiol. Lett. 248 (2), 241-248 (2005)
MDQVYLPQSVRTAVAVSFGVGLLYWVYRLLLQKTKSLKALDLPVLQSVGDQDIVKTLEEGHAKYPDTPFA
LGVPGQQLVVLPVSEIDTVKALPENQLSIKKHHYNQFLGEYSYMGTKADEFDDAMRYLLVRNTPAVLASF
TAEIDYAMSTVLQVPPNSWTRVKPRSIMPKVATILSGRAFVGLPLSREPDWIESNVNYTQDVSRAWMVLR
FYPHWIRPLVAPFLREVKTLEQNKALIGRKIAKLLADQEAQKLSPAQEKIPGGDMIDWFKSRYQAQGKTA
TAQQLTRDQLLATFASIYNLSNALTYVMFDLAANPAAVDELREELDQVLGPNVGAESIDKTALPRLIKLD
SFVRESQRLSPTSLVNIPRIVTDPNGLRLKTGHVIPPGYLVMVRAQPINQSPTLYPNPERFDAFRFARLR
QQGGANENRWQHTSTGADNINFGHGIWACPGRFFASAEIKVVVAYVIRHYDLRLIEGRPHPKPKYGGLAI
FPDAGAEVELKPRV
CYP5085A1 Neosartorya fischeri
96% to CYP5085A1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5085A2 Fusarium verticillioides
53% to CYP5085B1 Mycosphaerella graminicola
54% to CYP5085A1 Aspergillus fumigatus
not found in the F. oxysporum genome
see fungal pages for seq.
CYP5085B1 Mycosphaerella graminicola
51% to CYP5085A1 Aspergillus fumigatus
see fungal pages for seq.
CYP5085B2 Aspergillus terreus
55% to CYP5085B1
see fungal pages for seq.
CYP5086A1 Aspergillus fumigatus Af293
GenEMBL XP_749878.1 also EAL87840.1
missing first half of gene
54% to 5086B1
note the end of CYP65AA1 is only 11 bp from the stop codon
on the opposite strand
FLRPLVYRLIPDVQRVYQHNARARQLVGSIVKQREKDEATIPGYTKPNDAIEWIW
DLVPNEDKKNYGYQGIAQLAIAAVSVRRTSQLLTNIVLNLIAYPEYVPILKEEIENVLAS
CDGQWTLDSMSKLEKLDSFMKESLRFDTPLT (1)
ATFQRKAVQRITLSDGTVLQPGTLALAPCNAIAFDPNIYPNPEQFDELRFYKLRHQNDSK
ANNIIYFTAASKTQVQFGGGRHACPGRWFAAHLIKMVLA &
AILFKYDLKFRTGEERPKTWLFQTINTPDPKGKILVRTAQHV*
CYP5086A1 Aspergillus clavatus
54% to CYP5086A1, 38% to CYP602B1
see fungal pages for seq.
CYP5087A1 Aspergillus fumigatus Af293
GenEMBL XP_748328.1 also EAL86290.1, AAHF01000011.1
alkane hydroxylase predicted
missing C-term
MYTALGLAVFTALFHYTIVLAINHYRTREILSQLVKAHNCCPPKTERPWDILGLVKIYSSTKHLLNETAL
SNVSALFKCYGDTYASRILTQRVYFTCDPRNIRHVLINRFSDFDASDVRAHLFAPITPHGIFAVDGAEWK
EARSLYADIFSATRKIFDLQLQEDGFQGLIKQIPRGQAMDLAPLFLKLVLDVNSAFAMGTGLDTLKQDQS
LEKKEVAEALMYAKKIMARDGFLGPLHYLLSRKDFYAACETVKAYVEKVVRKEMTAREYQKQSNAATVDD
ERQKRTQSLLSRILDNTNDVHAVRDAVVTILIAGTDSVASMLSTTFYLLARHERVYAKLRQEILDTIGTE
PPTYDNIRKATYLRYVFNEAMRVYPPVPFNARTANRDTYLPAGGGPDGQSGVLIRKGQRVIFASWGSHRS
TRSFGADALEFRPERWEGLKSESLGYIPFSAGPRVCLG (1)
QQYALLEASYATIRIIQTFERLENRDVRPWTEKIGLNLSNKNGVLVELVH* 1196659
CYP5087A2 Aspergillus clavatus
AAKD03000001.1
94% to CYP5087A1
see fungal pages for seq.
CYP5087B1 Aspergillus oryzae
GenEMBL BAE63940.1
41% to CYP5087A1
MSPRGKMVQPIETPRQAFLAHPLTVILVGIILSLLVRRLLWNLKQRELERLHGCERLHNEGGCLRYDFLG
IAKAIKLGFHFRRRTSLPYTNALFKRYGETYASNVLGYRLIFTCSAENIKHLLSTAFADFDSSPLRKPLF
QPITPDGIFTLDGPGWKKSRDQLRSRLSNLRKIVDLNQCERHFQAFLQHVPPNGQAFDVQACAFALALDM
QTLFSLGESVDALSFCQSREKKQFLEDLLFVKEKIVQDGFRGPLRYLYPKRRFLHCCKRARRYVIAHVSR
QLTGCSSMSEKAEGAQPTNAEEE
VSLLADQALSILLANDSMSTTLSGLFFCLSQDERVVKKLTASILDTV
GLEPPTWGQLGTLHYVRWVLQEAMRLFPAVVFNARVANKNSTLPTGGGTNGNSPVLIRKGEIVVFSTWAR
HRLGKDFGENPDEFYPERWEHLSGDMIGFIPFNKGPRACPGQH YAMIVLTYIVARIFQTFSTVSNYDTRE
WTERISMTLENENRVLIGLS
CYP5087B1 Aspergillus flavus
99% to CYP5087B1 Aspergillus oryzae
see fungal pages for seq.
CYP5087B2 Aspergillus niger
JGI gene model e_gw1.3.514.1|Aspni1
71% to CYP5087B1
see fungal pages for seq.
CYP5088A1X Aspergillus fumigatus Af293
XP_752004.1 also EAL89966.1
Internal fragment, needs revision
44% to 68L1 A.nidulans mid region aa 183-260
similar to CYP5067A1 and CYP68 family
renamed CYP68L5P
CYP5089A1 Aspergillus fumigatus
GenEMBL XP_752692.1 also CAF32039.1
MVDVFVLRQLGVRDMVTLNCRMADERQGITDAINVSQSSQCTDLVGFQVGPCHLFSSRWHSGSDLSAERT
SIPRDIMSLAIILFALTLAAFIARVVYRCYFHPLARYPGPWFAHISNAWRLVAFFSGQHHLMEQRLHARY
GRVVRVAPNWLSFSTLEDFEAIYGFNKAIEKDEFYDFGRDRGSRPESIFAAKTETSHRVKKKKVVSPALT
STRITSYKPIIDKHVGILLTRLPSQSKGPLPEAKNNGTTAVNMAPIVHQCTLDAMLELVFGPRLSEHPYS
DTPAGEGVCSNLRIMTKMAWSFSLWPAFGWLMNTRPVNAMLRRPTYSKQGELTGMAGLMGVAMPRLLRNP
QQVVASSQPSIVKGWLEVPPDDATRMTPAEVASEASNLIIAGPGSTAAALTAVIFYLGTKDGQGWQERIR
EQIRASQSHDLGPSSLELQAVIKETLRLSAPFPTAFPRVIRPGAEMAIPSLAAPLPVGTTVSANTFVLGR
SRELWGNDADRWEPRRWLGSEQHRREMETKFVAFSKGSRSCIGRELALLLLAQAVIGIVQQWKFRSRGQL
QGKSFLEMQYDECWIKFEPLDLSLSA
CYP5089A1P Neosartorya fischeri
91% to CYP5089A1 Aspergillus fumigatus = ortholog
see fungal pages for seq.
CYP5089A2 Aspergillus oryzae
GenEMBL BAE60720.1
57% to CYP5089A1
MVSSTAFIVVQVALAALAAHVIYQCYFHPLARYPGPFLARFTNLWRLFTFFGGQHHLSEQHLHDKYGHVV
RVAPNWLSFSDLHDFDAIYGFNKSVEKDDFYLFGRPRDNRVPSVFALKTDADHRQRKRKVVGPALTTAKI
TRYESVVTKHVDLFFTRADAASASRQDGEMAAVNLAPLAHRFTMDVMLELIYGPDVVSHPYTDSATGADM
CSAMRKLVKMAWSFSLCPSYGWIMNSRLISGVLRTLTTSKQGGPTGMMALMTSSHTMIFRRPEQVSLPGQ
PGIVKSWLDIPLDDSSRMTQDEVFSEAVNLVFAGPGSVAAALTAMVYQLGTQEGQLWQEKLRKEADVEAP
PFSLELQAVVKETLRHCASFPTAFPRVIRRGAETIVSTLPAPLPIGTTVSANSYILGRSRKIWGHDADQW
LPQRWLGDESQRREMEAKLVAFSKGSRGCVGKELAWLVLAKAVMAIIRRWKFVSVGELRGKSYLEMQYDD
CWIEYEELA
CYP5089A2 Aspergillus flavus
99% to CYP5089A2 Aspergillus oryzae
see fungal pages for seq.
CYP5089A3 Aspergillus niger
JGI gene model e_gw1.3.357.1|Aspni1
57% to CYP5089A2
see fungal pages for seq.
CYP5089A4 Aspergillus clavatus
71% to CYP5089A1
see fungal pages for seq.
CYP5090A1 Aspergillus fumigatus Af293
XP_755776.1 also EAL93738.1
complement(join(AAHF01000001.1:1906434..1907040
AAHF01000001.1:1907095..1907853,
AAHF01000001.1:1908125..1908255))
Revised at N-term
MLSDAVSAAIDWTGQGISWVKQEYPALTVAVTSACVLVLWRIWR
FTILPSFHPNDPKELPYCIP (1)
WHGAAFFSNSNALLSRAR (2)
NYFNNIQDPFALSIANSLIYVITKPQ
DVAEAYRNTDTLSFNEFVQAMMRACGNTESCVKTMYKPLPKDKPGFPNPHGKPLATLARQMHIHQLYPGD
NLDFLEKQFLDWVEPRLTLDALRRECPYAIQSGPPAVTKDDGIVLPLMQWCSDYFTRAGQRAYFGPALDG
IDPKLPQTFIVFDELSWQVLYQYPEFLAGKMKSARNAIQRALKKYIQLPQESRQGDAWFTKAMENEMRAL
GISEDDIATMLVTIYWGINTNTRKAAFWLLTYILHYGPEHYVDIIRQETLPAFLPDKSIPDLNYLHDNCP
HLDAMWNETIRLSAYSASVRFVTSDTIIGGKILRKGNRLMIPYRQLHFDESIFGVDYPVEEFRHERFMQK
GRNLTRSDNWRPFGGGTTQCPGRYVAKRFVLLFVAMLLRRFDVELVTTRIPAAEEGKPVLGIMSIKDGED
VLVRVRPR
CYP5090A1 Neosartorya fischeri NRRL 181
XM_001260900
96% to CYP5090A1 A. fumigatus, ortholog
Revised at N-term
MLSDAVSAAIDWTGQGISWVNQEYPALTVAVTSACVLVL
WRIWRFTILPSYHPNDPKELPYWIP (1)
WHGAAFFSNSNALLSRAR (2)
NYYNNIQDPFALTIANSL
IYVITKPQDVAEAYRNTDTLSFNDFVQAMMRACGNTESCVKTMYKPLSKDKPGFPNPH
GKPLATLARQMHIHQLYPGDNLDFLEKQFLDWVEPRLTLDALKRECPYAIQSDLPAGK
KDDGIVLPLMQWCSDYFTRAGQRAYFGPALHGIDPKLPQTFIVFDELSWQVLYQYPEF
LAGEMKSARNAIQRALKKYIQLPQETRQGDAWFTKAMENEMRALGISEDDIATMLVTI
YWGINTNTRKAAFWLLTYILHYGPQHYIDIIRQETLPAFSSDKSIPDLDYLHDNCPHL
DAMWNETIRLSAYSASVRFVTSDTIIGGKILRKGNRLMIPYRQLHFDESIFGVDYPVE
EFRHERFMQKGRNLTRSDNWRPFGGGTTQCPGRYVAKRFVLLFVAMLLRRFDVELVTK
RIPAAEEGKPVLGIMSIKDGEDVLVRVRPR
CYP5090B1 Metarhizium anisopliae var. acridum Ma102
CYP5090B1 Metarhizium anisopliae var. anisopliae Ma23
CYP5090C1 Metarhizium anisopliae var. anisopliae Ma23
CYP5091A1 Aspergillus fumigatus Af293
GenEMBL XP_755777.1 also EAL93739.1
join(AAHF01000001.1:1908934..1909376,
AAHF01000001.1:1909470..1909557,
AAHF01000001.1:1909606..1909750,
AAHF01000001.1:1910034..1910304,
AAHF01000001.1:1910386..1910566)
revised
1908580 MLEILVTFLIFCFRRIRGLWYLARGPEIIDRAYIA 1908684
AEGKPFRIYTPSNDHLLVTSKEHIAELVNAPLQNLSLHAVAKE (0)
ILQPKYT
MFGFEWHNQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGSPQLCLIPSDCS
RLRALQTVPYDQANGHQGQLLRLLRGGTWYDYPWHVRHRQAHCVAAQNPEFTAAALEFPQRVILAAEILR
ITPSFLR (2)
RTLFRYLKPIVEKRLAARANSPRSLQEDAP (0)
MDCMQWLIDTSPRKIPWTPTRMVGEIVAVWFGS
VHQLAM (0) 1909749
1909815 TTTYAIEDLCLHSDYVEPLRAEIQQYLEGPCRRRVAEMPLLDSFVRESIRCTNSDA (1) 1909961
1910033 LTVRRKALTPFMFSDGLEVAEGDWVCIPQRAMMRDRIRYQNPQAFDGFRFARANK
QLRAGDVSLDVPENSPLTMTDVSVDWPIWGLGKTACPGRFYAATILKLIMVCILEKWECRLENPKSQRWR
TWRSSVVPREGTVVMFRRKEEALTG
CYP5091A1 Neosartorya fischeri NRRL 181
GenEMBL NW_001509762.1
Also called CYP5126A1
ortholog, 92% to A. fumigatus XP_755777 revised
MLEILVTFLIFCFRRIRGLWYLARGPEIIDKAYIA (0)
AEGKPFKISTPSNDHLLVTSNEHIAELVNAPLQNLSLHAVAKE (0)
ILQPKYTMFGFEWQDQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGPP 530
531 QSCLIPSDCSRIRALQIVLYDQANGHQGQQLCLLRGGTWYDYPWHVRHRQAYCVAAQNPE 710
711 FTAAALEFPQRVILAAEILRITPGFLR 794
5164664 RTLFRYLEPVVEKRLATRANSTRSMQEDAP (0)
MDCMQWLIDTSPRK 5164843
5164844 IQWTTTRMVGEIIAVWFGSVHQLAM (0)
TTTYAIEDLCLHSDYVEPLRAEVQQYLAGSCRRRVAEMPLLDSFVRESIRCTNSDA (1)
ITVRRKALTPFVFSNGLEVAEGNWVCIPQRAMMRDRIRYRNPQAFDGFRFARANKQLRA 5165393
1626 GDVSLDVPENSPLTMTDVSVDWPIWGLGNTAS (2)
PG 1806 RFYAATILKLIMVCILEKWECRLEDPKSQRWRTWRSSIVPREGTVVLFKRKEEALTG 1976
CYP5092A1 Aspergillus fumigatus Af293
GenEMBL XP_756135.1 also EAL94097.1
Gene model is short needs revision, missing C-term
complement(join(2910619..2911240,2911273..2911511,
2911803..2911958))
84 kb from pksb too far to be in the gene cluster
1 MLLLTFTLPV VTLLLAHIIR SWFRLRHIPG PFWAKITDLW REHHYIKGDY GDRPMAPYFA
61 IPSLLGMESA MDQIQQELED QICRRVTIDV VLWMRLFSLE SLHWIAFSNK LGYLSEGKDT
121 DGILSILQSK FIGLAGQLCG WIHRTTLRFH FPKSCTGTAV APSQRKASHR DLLAHFMDAS
181 QKNPETLEER GVLGATISTI FAGTDTTGTS LTFFMYYLIK HPAALARLQE ELDSAVRSGN
241 LSYPPKWVEV STLKYLQAVF KETLRLHSTA RMSLYRVVGP EGLDLCGERL PSGTNLGCFG
301 YTAHRNEPIY GRDAALFRPE RWIEASNDTL LSMERASL
CYP5092A2P Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_3000010|Aspni1
41% to CYP5092A1 aa 241-396
MAKQAPEEYNQVGVLGATLTIIGAGSGTTEYLLAFLLRSI V*CPRIKQRLRNELRLAISEGRLPQLPEWAEVSKLQYLGTIVREGLRL
HTPVQSTMNRVIGPGGLDLCSRWIHAGTTVGCFLQAFHLNKDVYGTDAREFGPKRWVEVLEEHVKSMERGGFWFGSGKHV
CLGQHVARMGITKLVASIFMRLENALFMMIGPKKVPEVSPGASLQMSPSVSSRLW*
CYP5093A1 Leptosphaeria maculans
GenEMBL AY553235.1
sirodesmin biosynthetic gene cluster, SirB gene
note: a second P450 SirC exists in this gene cluster
Sir C = CYP5082B1
MSTLQDFQIAPAILHRVTVRDASAILFCTLLTVFLFISQGTVRG
VKRVGKSRLRTLVTGETPLRFDLEKYGYLGYQQFSKKANKPFLVKIYGLDHYVLPVKY
LDSLKTVDHHRLSFAQSLNDF ()
26242 LNVDASLGDLVTHSDMEIAVVTKHLNPRL ()
TTLTPVLVDEANFAFEKELGKLE ()
TWKTVNALFLSAFLTNRTSGRVLVGDLCRDDNYLHAMMKYTES
VFSSGVAFNGIPLGPFRKIVYYLGARQHRRDLDNAAALVLPEIKRRMAAQAEDPNCRK
ENDAIQWNLDLPLASPKEGLPLRHAHRVLHLSFAATGTVAILITHMIYNVLMYPEYLE
PLREEVMACTKAHGGWTEKAMNEMWKLDSFIRETLRVQPPSVFTAYRTVKNQPFTFPD
GFTLPVGSRITFPTLPVGLDPENYESASEFDGFRFFRKREEARLAKKAYNWGATKIDS
SFLPFGYGNQACPGRFFGVRKTKILFGKLINDYDFSWAEPRSARPENIVIEGQILVNP
TPEIKIKSRVAAGM
CYP5093A2 Aspergillus oryzae
GenEMBL BAE63236.1
75% to 5093A3, 35% to 546B1 Fg, 36% to 546A2 Mg
MDYIHSLPSNPALGLSCCIIFILLAIVLHDVYMWKCLPPGPPPIPLIGNKFQIPSKHPWIKFEEWSNVYG
PIYTIWLGRRPTVVISDPSIASELLEKRSTKYSTRPRFVTMGEIYWDMASILVQPYGKEWLIRRRLLHSA
LTPRALDNYTPLQEAESSRLCYQLLESAHEWEPLFDRLASSIVFAVSYGHRVDSAQSPVIKQRLDFMQYA
SSLNVPGAHLVESFPVLKHLPDWIAPWKAEIKRRGRLEAEANMTLVRVVQQDVESAKESPGAEPLFNSLT
KQLLETRDSDPTAFPLSERDFSYIPASLFGAGSDTTSSTLCSAMLAIVTNPRTMEVAQLELDSVVGRDRL
PTFEDIPNLPYLRAFSKEVLRWRPVAVLGGTPHACSEDDYYRGYYIPQGTVMLGNSWAINMNPKYYPNPD
QFNPLRFLDMDPHLLPYLPKEYTASAEQEKGSGHPSKLGHSSFGWGRRICPGADLATNTLLITLSRLLWC
FDIRPIPGQTYDTLDYTNGFNIRPRSLHLSLQVRSDQHRQVIERGYEVATKFLERLSPFDERMQGNS
CYP5093A2 Aspergillus flavus
98% to CYP5093A2 Aspergillus oryzae
see fungal pages for seq.
CYP5093A3 Aspergillus terreus NIH2624
GenEMBL AAJN01000232.1
75% to 5093A2 no introns, 36% to 546B1, 35% to 546A2
49905 MEHLRTLLSSTLVWGAGCGILLIVLGILVHDVILWKRLPPGPPPFPLIGNKLHVPSKHPW 49726
49725 IRFRDWSKIYGPIYTIWFGRRPTVVISDPTVAAELLEKRSTKYSTRPRFVTMGEIYWDMA 49546
49545 SILVQPYGKEWLVRRKLLHSALTPRALDNYKPLQQAESARLCYQLLQHADRWEALFDRLT 49366
49365 ASIVFAIAYGHRVDDFRSPVVRQRLEFMQYSSSLNVPGAYLVESFPILKDLPDWMAPWKA 49186
49185 EIKRRGRIEAEANMNLVRVVQRDIESANEAPGTAHIFNSLTKQLLEIRGQDPASFPLTDR 49006
49005 DFSYIPASLFGAGSDTTASTLCSAMLAIVTTPMVLEMAQAELDSVVGYDRLPTFEDMRNL 48826
48825 PYLRAFCKEVLRWRPVAVLGGTPHACSEDDFYNGYYIPKGTVILGNSWAINLNPEYYPNP 48646
48645 DHFNPLRFLDVEPHSLSYLSEQYLSSTKQEKGTSHPSKLGHSSFGWGRRICPGADLATNT 48466
48465 LLITLSRLLWCFDIRPVPGRTYDTLDYSSGFNIRPRNLHVKIKVRSDHHGGVVEREYGDA 48286
48285 SEFLETLPPFEDSLPEHSPIKM* 48217
CYP5093A4 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000340.1
60% to 5093A2, no introns, 39% to 546A2, 37% to 546B1
MPLESVFKL
211788 PAYIWASLIFAIPLVALLHDVWVWFRMPPGPTPIPFLGNKHQLPKSKPWIQFQEWSKTYG 211967
211968 PIFTIWIGRKPTIVISDPIIAVDLMEKRSTKYSSRPRMVAMGEILWDGASILVQPYGKEW 212147
212148 STRRKLLHQALTPKALRLYKPVQTAEASRLCSQLLETPANWEKLLERFTSSIVFSVAYGH 212327
212328 RIDSLNADVIYQRFKFMHVAASLNVPGKYQVESFPILKHVPDVLAPWKAKIKAQGREEAA 212507
212508 ANMALVDVVRNDMARAKTRGEDIPDSLCKLLLEMKETEHIPLSDRDFSYIPASLFG 212675
212676 AGSDTTASTLCTAFLALVTHPETLQAAHSELDAVVGTNRSPTFDDEKDLPYLRALVKEVL 212855
212856 RWRPVAVLGGTPHASTEDDYYEGYYIPAGTTVLGNSWAINLNEEYYPNPHLFDPMRFLDS 213035
213036 ALSEKLKAPTGLTGKAHPAKTGHSSFGWGRRICPGAGLAENSLIIALAKILWT 213194
213195 FDILPVKGVKYDTFAYTEGFNIRPKSFRCEIRIRSEVHRKVLEEDFKSAEGVLERFTPFG 213374
213375 E* 213380
CYP5093A5 Mycosphaerella fijiensis
JGI gene model e_gw1.21.282.1
66% to CYP5093A4 Phaeosphaeria nodorum
see fungal pages for seq.
CYP5093B1 Aspergillus oryzae
GenEMBL BAE56598.1, AP007154.1
45% to CYP5093A1
83% to CYP5093B2
revised
81343 MASESSIPLYDCLIIGGGIAGLSSALSLVRTLHTAVVFDEGIHRNDQAPHLATVPTWDSQDPKRFRDAAK
LNILSKYSTVEFANVKLEKFNKALGKPFLTKVFGHDYVVLPSKYFDDIKRASPQSLSFFQALSDGLNMEA
SVGHLYASTTEIDVVVKHLNPRLTQLTPLLCDEAEYAIEREVGALPDWKKFNVSNLIAAIVHRTTNRILV
GKELCRNEEYLAITTKFSRSLFISGIFWNFVRLGPLRKLVAWLTIGLHLRDRNAAAKVLLPHVLARRQEK
EAGVDVATKYPDALQWTIDTAPSFPGDDEPLHQVYHMLHLTFAASSASGVGVTQCLLNVLAYPEYLEPLR
DEISTVVARHGGWTDKALSQMALLDSFIRETMRLHPAGS (1)
LTVARTVMDDHFRFHDGLTLPKGTNIIAPALAIHYDP
DNYEDAHRFDGFRFARYRQKQGENHRWLASTIDQKFLQFGYGNHACPGRFYAIRKIKLVLAKLIMDYDFK
WAQPRPVHDRPEDFAIEAQLVAAPDAEILIRSRNLSN 78253
CYP5093B1 Aspergillus flavus
99% to CYP5093B1 Aspergillus oryzae
see fungal pages for seq.
CYP5093B2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000026.1
82% to CYP5093B1
revised
366479 MASEQVPLYDCLIIGGGIAGLSAALSLVRTLHSAVVFDEGLHRNDDSPHLATIPTWDSH 366303
366302 EPKTFREEAKLNILTKYSTVEFADVKLEK (0) 366216
365065 VNKALGKPFITKVFGHDYVVLPSKYLDDIKRASPKSLSFFQALSD 364931
364878 GLNMEASVGHLYASTTEIDVVVKHLNPRL (1)
364727 NKLTPLLFDEAEYAIRKEIGPATEWKSFNVSNLIGAIVHRTGNRILVGPELCRDEAYLAAT 364545
364544 TRFSRSLFLHGIFWNFVRLGPFRKLIARLTIGLHLRDRDAAARMLLPHIHSRRQEKASGV 364365
364364 DVAAKYPDALQWTLETPSSFPGDDDPLHQAYQMLHLTFAASSASGVGVTQCLLNVLAYPE 364185
364184 YLGPLREEIKTVVARHSGWTDKALSQMALLDSFIRETMRLHPAGS (1)
LTVARTVMDDQFRFHDGLTLPKGANIIAPALAIHHDPENYTDGSKFDGFRFARYR 363825
363824 QKQGDSHRWLASTIDPKFLQ (2)
363709 FGYGNHACPGRFYAIRKIKLVLGKLLMDYEFQWATPRSVNSRPEDLAIEAQLMVAPDTE 363533
363532 VLIRSCRA* 363506
CYP5094A1 Aspergillus oryzae
GenEMBL BAE64919.1, AP007171.1
36% to 681A1 in CYP53 clan part C
14 P450 genes and 2 pseudogenes on this contig
MASLTGAAAVLLAFILAYSTALTIYRLFFHPLARFPGPRLAAATKWYEFYFDIIKSPGGQFFKELSRMHD
VYGPIVRVNPDEIHVRDAAWFEVLYAPNPTKRNKYRPSAEMAGLTLGIHGTVDHDLHRRRRMAIAPMFNK
QSILSAEHLIKQHIDELTDVFESYLGTNNPINLQTTFLAYTTDVLYHYMFDTDAGYQRDSGAAQQWRHSM
DAVAQATPFLKQFPSLLSRVALIPLPMLIWVLKRIQPDVAGLLGTHQLMASIVSKYMASKPEEDQDELIA
TKAVKPRTLFHAIEASSLPPHEKAPTRLAQEGLTVLFAGGETGSRLLAHTVYHLLKNPEILEKVRKEILD
AAGDSNQLPDMKALEALPWLTASVRESLRLRAATTSRLPLVTEKPLAYADWVIPPNTPVSMSHGDILHNE
DIFPDPMKFMPSRWFNASPQQNRLFVPFGKGTRMCVGMNFAYCEIYMSLAVILARFDLELYDTRWERDVH
YTRDCFLGEPDPASPGIRVKVVADHKTFTRS
CYP5094A2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000032.1
77% to 5094A1, 35% to 681A1
260809 MTSSLPIPLQVLNLG
260854 LSFIFAYLTSIIIYRLYFHPLARFPGPKLAAATKWYEFYFDIVKRPGGQFFQELNRMHEIY (1) 261036
GPIVRVNPDEIHIRDPSWFDVLYAPNPTKRNKYWPSAEMAGLTLG (1) 261228
261296 THGTINHDRHRRRRMANAPMFNKRSILSTQGLIKQHIDELVEVFASKSGTDEPVDLQTTFL 261478
261479 AYTTDVIYHYMFDTDAGYQRDPKVARKWRHSMEAVAQATPFLKQFPNLLSNLLRIPLPIL 261658
261659 IWVLKRVQSDVAGLLETHQ (0)
LMAKIVSKYMATKATEAQSETDEE 261838
261839 SKKVKPRTLFHAIERSSLPPDEKQPPRLAQEGLTVLFAGGETGSRFLAHTVYHLLCNPDI 262018
262019 LDKVKKEILDAAGESNEVPDVRTLEGLPWL (0) 262108
262165 TASVRESLRLRAATTSRLPLVVEQEMVYQNWVIPAN (0)
262345 TPISMSHPDILHNDSIFPEPLRFRPARWFTATEQQNRLFVPFGKGTRMCVGMD (2) 262503
262562 FAYSEMYLSLAAILPRFDMELYETDWERDVQYSRDCFLGEPDPRSPGMRVKVVAD 262726
262727 NKAFALTETAMVS* 262738
CYP5095A1 Aspergillus oryzae
GenEMBL BAE66500.1
44% to CYP5095B1
41% to 682D2, 36% to 551A1, 34% to 551A2, 38% to 682D1
note 682D1 probably has a small intron after the KYG
MGFTQDLVSVIRPSIESPLAFCATTVVAVALYVLVLGVYRITLHPLAKFPGPKLAAFTQWYETYYEFFKS
PGGQYLFHYRKLHEKYGPIIRLSPFEIHIQDSSFFEEMYSQSLPWDKPKELEHRFGNANGLFPTHKHEVH
RHRRAALNPYFSKRAINNAVPMMQEQITKLCDRLRREYQGTGKVFRLDWMMGCIASDIIVRYCVDRGYDF
FEAPDFKSPFIQALFDLLDGVHMITQFPWVATLFNSLPQGLVETLQPGMKSVHHFHKEMADQVAHILSNK
EKRNGSEQTNVFNALLDSDLPPEELTLTRLQQEAFTVIGAGFDTTRYALSVAGFHIINTPSIYQRLREEL
KTAIPDPSNMPSLTDLEQLPWLTACIQECVRMSYGVSQRAFRISDHITLTYKNYVIPPGTVVSMDNYSVA
HDEEIFPESFTFKPERWLGDPLAPDGKKLTRYLVSFGKGTRSCLGINLAYAEMYLTIANVFRNFDFELFE
TDRSSVDCYRDMFLPHVKLGSQGVRVKIN
CYP5095A1 Aspergillus flavus
99% to CYP5095A1 Aspergillus oryzae
see fungal pages for seq.
CYP5095A2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_15000164|Aspni1
67% to CYP5095A1
see fungal pages for seq.
CYP5095B1 Aspergillus nidulans FGSC A4
GenEMBL AACD01000118.1
AN10887.3 Resulted from split of AN7082.2
44% to 5095A1, 39% to 682B1
73084 MTMIDLNPDLSFTAKSVALLLFIALGL
73115 LYTTIQVVYRLYLSPLSRFPGPRLAAATGWYEAYFELVHKGGGQFLFEIRRMHEVY (1) 73282
GPIVRINPFELHIADPAYYSTLYTSTLNLDKASHIQHRFNAPTAAF 73474
73475 STPEHALHRRRRAAISPFFAKRRIDEQAPMIQSHVNVICHRLSEEYAGTGKVLCVNELYG 73654
73655 SYVTGVIMTYAFNRCPRFLEEEDFVSAFGKSIQGLKEFVHWAQQFPCLPRILQNVPPVLM 73834
73835 GALFPAMQASLVFQE (0) 73879
73939 EMRMQAHAVLSGHGQKGTIFHDLLASDLPRSELTLPRLKDEAMSIVGAGIETTK 74100
74101 MASVVTTFHILQNPRILQKLQDELDSAIPDPTAPPSLSVLENLPFLAACIKEGIRLGYGA 74280
74281 TGRSPRISRTESLRYGAWSIPVGVMVSMDSYHMHHDESVFPDSYAFVPERWLDGARGPDG 74460
74461 TGSLNKYLASFSRGTRMCVGINLAYAEITIVLARLFRGFVMELYQTTRKDVDCYRDLVGM 74640
74641 EVVRGSRGVRVKVVGRRE* 74697
CYP5095C1 Mycosphaerella graminicola
42% to CYP5095A2, 39% to 5095A1, 38% to 5095B1, 33% to 682B1
see fungal pages for seq.
CYP5095D1 Mycosphaerella graminicola
41% to CYP5095A1 Aspergillus oryzae, 39% to 5095B1,
35% to 682B1
see fungal pages for seq.
CYP5095E1 Mycosphaerella graminicola
41% to CYP5095A1 Aspergillus oryzae (borderline member)
40% to CYP5095A2, 39% to CYP5095B1, 37% to CYP5095C1
see fungal pages for seq.
CYP5095F1 Mycosphaerella fijiensis
JGI gene model e_gw1.7.701.1
45% to CYP5095E1 Mycosphaerella graminicola
see fungal pages for seq.
CYP5096A1 Aspergillus oryzae
GenEMBL BAE61439.1
in the CYP53 clan part C
39% to 682D2 but only 33% to 551A2, 32% TO 5095A1, 36% to 5095B1
MMPTFFQAVCSTCIALAIYTASLAIYRLFLSPLAKFPGPTLAALTGWYEVFFDVLLGGQFMWEIERLHGK
YGPIVRINPHELHIKDPDYYNTLYAGPTRRRDKYLWFLSVGAPTSTFATPESDHHRLRRGMLSPFLSKQA
VRDLEGVIKAKLDLLCEHMKKAMRSGEAVELHAYFVSFAVDVVSTCAFGESGCFEELRRERLDDRWKNVV
TGAFGKLLLTRHFPWLVVVFRFLPVWATALLTPVVRHIDYMEKGVENQMQHVYAMNKDGVKENGIFSQLM
HNLKLPLKERVLYRLADDAKFLMVAGIDAPSQVLAITMFHVLRSPLVCRELREELQDKTAHSRDELCLNT
LEKLPYLTAVIKEGLRVSAVVTSRLPRIAPEETLEFRGWKIPPGTPVSMSSHFILRDPAIFPDPLVFQPE
RWLKQSTTGSSLDRYLVPFSKGSQGCLGPNMAHAWLYLALATLLQRFEFSLFETTEENIRTVRDCFNGQT
KPGQNNIRVKVLTEFI
CYP5096A1 Aspergillus flavus
99% to CYP5096A1 Aspergillus oryzae
see fungal pages for seq.
CYP5096B1 Aspergillus niger
JGI gene model e_gw1.2.1500.1|Aspni1
47% to CYP5096A1
see fungal pages for seq.
CYP5097A1 Aspergillus oryzae
GenEMBL BAE60821.1
MDLTLHLILFLCFWACYLLFEKQLQQRSPLPPGPTPLPIIGNILQFKRKQAVWETISQWSDQYGPIMSFK
VASRTIIVLSTNQAIRDVLEKTPVNSSRPRFIGVNENLTRSMMPIFLPISDKWKAIHRVQLSLVNSRSAK
GIAEIQLLTAKQHLFNMLENANYDIADHINRFTSNVVSTVLFGTNIGSVSQAKSNGKFGLADQFIASICV
EHALVDLFPILEHIPGVARLGASKGNAWFESIRQQYTEDIQRAINSPTWSMIKAAHQQKIGGMSEDAFRM
WNVEMEFALGMTSSMMIANLVAMAVSHSHEFRQVQSEIDRVVGPERLPTADDLAHLPRLHAFVKEGIRVA
PIVPFSVPHAAVEENEYMGYRIPVDAIILPNQWHINREPKYFEDPAEFKPQRWIDNPNLPGPALVGYGIR
ICPGRQTANNGLLIVLALMAWGFDLNHAGGVKEPPNVLETLIMKLPTSSIRYSCRSSVHRDLIQKEWLAS
DDDPSSILNTLGSSLGF
CYP5097A1 Aspergillus flavus
99% to CYP5097A1 Aspergillus oryzae
see fungal pages for seq.
CYP5098A1 Aspergillus oryzae
GenEMBL BAE60012.1
MGLILAFAVILLSTCWFLWYSRKAVFDRLPPGPRPLPFLKSRQELRQTRQWEALDDLHRQYGPLVGMTWG
GRPAVLIGKREIAKDLFGKRGSIYSSRARLVMGLDIMTGGDHVFFLPYGPKWKKLSRIQATFLNRPAVKH
YRPLQELESLHTLQDLLHSDDYEACFSRFQASLTHALAYGTRLHSATDPQLTELENIARTFISAATNSHW
MVDSFPILKYVPACLAPWKRFGQQIHAQTVSLFQGKMAVAEHTRSWNWVKHIRALKHTSGVTDHEMVYVI
GSIYQAGVGIITATLRLFIMACVLHPEAVKAAQDELDRVVGSDRLPTLNDLGHLPYVEAFVKEVLRWRPL
VLAATHSVTQDDDYRGYRIPRHAVILSNQWAMDMDREVWDSPEQFRPDRWMSDRKRMPSAFGLGQRMCAG
QYMAMESLLIMASRMLWAFTFEHAWEGGKRVEIDSWAFHEESLFLVPKPYRARIQPRDPHRLHVIQSTWQ
AAEKDIDPLLDQIGREIHTASA
CYP5098B1 Aspergillus niger
JGI gene model gw1.3.1436.1|Aspni1
51% to CYP5098A1
see fungal pages for seq.
CYP5099A1 Aspergillus oryzae
GenEMBL BAE56799.1
MEHHTWALFVDKLDYKAVFGLLLTIIIAVVTTQILHVYTKCCPGIPSIPFHISVYDAYRRVSEIGFHNSR
LRPVLETHGAVNIWNSGQWAVLVTKPEYVVRILRNERVVAKGGFYGKVPHSTLAGLFGENIIDSHGELWK
QFTGVMKPGIQRPHSISSLKVASSKLIATFKREQQHAPSDRGVVIDDIIERWAIDVFGESFFDVDFGALN
GGTVRAQDALLAILWNLGGHLIHHFPMFERIGWPLRPTRPHCFSMIRELEEALIDITEKLKYPETPPDRF
EKVIYRLKRARDDGLMTDFHYRSNLKMMFFAGHENVKFAFIATLWELSQNPQMQEKLYREIAAHIASSSD
GDDLKSLPYLTAVLAETLRLYPPVSQLINRKTLEPVYLGNGITIPQGMWVGWTAYGVHTDPNTWGPTAHE
YQPERWGDDVHAIQRAISQQQVRGSYIPFNAWTRSCIGSEFALLQLRVTLYEIVRHFEITSAPDYRYSIK
VIWSCAFLLRHRIYGRCSRVYGSSEGGC
CYP5099A1 Aspergillus flavus
99% TO CYP5099A1 Aspergillus oryzae
see fungal pages for seq.
CYP5100A1 Aspergillus oryzae
GenEMBL BAE65915.1, AP007174.1
29% to 639A1 very poor match to other P450s
C-term on BAE65915 gene model is not a P450 seq = MFS transporter
1252988 MPAISLSLIGIGVVAVGTVWALWALTRKLQVPNNYPNAPRSLPYSIPFLKSTIPFVLDGLNLFRQAS (2) 1253188
1253239 LYCQDRWPLRVDLLNGEVYIVQGAKNIASIFSTPGLTVTQAYGIALKHCFGMEQKAVDAYLADTSGSWHRPIP
GSQTPWHGRVSYHTHENLVRGLLGAGLDPTTERIERLLLASLEGAVSRTSEWTYGMDLTEFFETHLGSAI
LQALYGPLLVTKNSDFNRNLWRYDKQIMRLAKRLSSWLIPEAYRLRDELLGAIMRWHQQATLLSETIPSC
ERTSGGEADPYWGSAMMRERNKMLLSIEGQDAKSVASTDLGFIWA (2)
SVTNVVPSTMTLCTHMYRDHSLVEN
IRLAALNCIRPGATLRFDLNKLGKQPLLLSMYAETLRFGVQIHIPRCSPHQPLSVAGVTIPPDKMIFINT
SLAHTDESVWNTRNGEHPLDTFWAQRFLIDPKDEGSGPTRKECSQPLESTPRGEYKRMDGQGSSSGQFTL
EGLDGSWIPYG (1) 1254606
1254672 GGQHACPGRILAKRIILLASSMMATMFDIELLAPNSLQFGSPRFGFGVRKPSAQVPFRI
RRRKSVSQDPFIC* 1254893
CYP5100A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000177.1
98% to CYP5100A1 Aspergillus oryzae
22528 MPAFSLSLIGIGVVAVGTVWALWALTRKLQVPNNYPNAPRSLPYSIPFLKSTIPFVLDGL 22707
22708 NLFRQAS (2) 22728
22785 LYCQDRWPLRVDLLNGEVYIVQGAKNIASIFSTPGLTVTQAYGIALKHCFGMEQKAVD 22958
22959 AYLADTSGSWHRPIPGSQTPWHGRVSYHTHENLVQGLLGAGLDPTTERIERLLLASLEGA 23138
23139 VSRTSEWTYGMDLTEFFETHLGSAILQALYGPLLVTKNSDFNRNLWRYDKQIMRLAKRLP 23318
23319 SWLIPEAYRLRDELLGAIMRWHQQATLLSETIPSCERTSGGEADPYWGSAMMRERNKMLL 23498
23499 SIEGQDAKSVASTDLGFIWA (2)
SVTNVVPSTMALCTHMYRDH 23678
23679 SLVENIRLAALNCIRPGATLRFDLNKLGKQPLLLSMYAETLRFGVQIHIPRCSPHQPLSV 23858
23859 AGVTIPPDKMIFINTSLAHTDKSVWNTRNGEYPLDTFWAQRFLIDPKDEGSGPTRKECSQ 24038
24039 PLESTPRGEYKRMDGQGSSSGQFTLEGLDGSWIPYG (1) 24146
24215 GGQHACPGRILAKRIILLASSMMATMFDIELLAPNSSLQFGSPRFGFGVRKPSAQVPFRI 24394
24395 RRRKPVNQDPFTC* 24436
CYP5100A2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_9000313|Aspni1
61% to CYP5100A1
see fungal pages for seq.
CYP5101A1 Aspergillus oryzae
GenEMBL BAE65910.1, AP007174.1
first exon may be wrong
MGRSRSTDWR ()
NSSALFARAKKEFRHKLCALRIAGQDMVMVTTAAQIAAIDKDSPTFAFEPFVDLVYDEIA
TVSRESKPLLWRTPAEGYKSLFPSAKQMTAAHTGIHLLHKQLTQPDAMHRFMTNSLVHVNNTLQWDSFYN
TSVLAATADVKVVSLECLCRDVIIDAQLTSFFGPRILEIEPDIRSFLKAWDSISWKVSYRLPSFLAKHAT
QLRDHLIEVLVKYYAFPAEERPGSVSFVNDVYDDYKQAGIPDRDIAGIVFTILWGLNSNVNAISYWMIAH
LMNNPTVVNEIREEIAPMMRALDSSPTIDGTILADVSKDPLLNSCPIMNSTFNETLRFTATGSSFRETTR
DTTMDGRRIPKGTKNIIPQRTQMMHSAAFGPDPETFDCYRFYRNKSLLRKVEFRGFGGGTTLCSGRVVGR
HQVLAYLALLFWRYDLEVIGPDQEVLGVRGKGFPRLDEAKPSLGPGKPIDGDDQILRLTRRNV
CYP5101A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000177.1
99% to CYP5101A1 Aspergillus oryzae
12856 MGRSRSTDWR ()
NSSALFARAKKEFRHKLCALRIAGQDMVMVTTAAQ 12677
12676 IAAIDKDSPTFAFEPFVDLVYDEIATVSRESKPLLWRTPAEGYKSLFPSAKQMTAAHTGI 12497
12496 HLLHKQLTQPDAMHEFMTNSLVHVNNTLQWDSFYNTSVLAATADVKVVSLECLCRDVIID 12317
12316 AQLTSFFGPRILEIEPNIRSFLKAWDSISWKVSYRLPSFLAKHATQLRDHLIEVLVKYYA 12137
12136 FPAEERPGSVSFVNDVYDDYKQAGIPDRDIAGIVFTILWG () 12017
11949 LNSNVNAISYWMIAHLMNNPTVVNEIREEIAPMMRALDSSPTIDGTILADVSKDPLLNSC 11770
11769 PIMNSTFNETLRFTATGSSFRETTRDTTLDGRRIPKGTKIIIPQRTQMMHSAAFGPDPET 11590
11589 FDCYRFYRNKSLLRKVEFRGFGGGTTLCSGRVVGRHQVLAYLALLFWRYDLEVIGPDQEV 11410
11409 LGVRGKGFPRLDEAKPSLGPGKPIDGDDQILRLTRRNV 11296
CYP5101A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02005071.1
98% to CYP5101A1 Aspergillus oryzae
runs off the end
this seq does not show up in the Broad comparative blast server
17 QQMTAAHTGIHLLHKQLTQPDAMHEFMTNSLVHVNNTLQWDSFYNTSVLAATADVKVVSL 196
197 ECLCRDVIIDAQLTSFFGPRILEIEPNIRSFLKAWDSISWKVSYRLPSFLAKHATQLRDH 376
377 LIEVLVKYYAFPAEERPGSVSFVNDVYDDYKQAGIPDRDIAGIVFTILWG 526
594 LNSNVNAISYWMIAHLMNNPTVVNEIREEIAPMMRALDSSPTIDGTILADVSKDPLLNSC 773
774 PIMNSTFNETLRFTATGSSFRETTRDTTLDGRRIPKGTKIIIPQRTQMMHSAAFGPDPET 953
954 FDCYRFYRNKSLLRKVEFRGFGGGTTLCSGRVVGRHQVLAYLALLFWRYDLEVIGPDQEV 1133
1134 LGVRGKGFPRLDEAKPSLGPGKPIDGDDQILRLTRRNV 1247
CYP5101A2 Talaromyces stipitatus ATCC 10500
ABAS01000018.1
73% to CYP5101A1 Aspergillus flavus
N-term not identified
see fungal pages for seq.
CYP5102A1 Aspergillus oryzae
GenEMBL BAE65870.1 AP007174.1
heme signature very altered only C is conserved
EST EY425739.1 confirms N-term
EST EY432141.1 confirms C-term
Revised 3/15/2009
1128173 MVVCVITVLILGFLASVRALCNYTRLSTVPGPLFTGLSDLWRTYARSTSDYGCSLAGLH
MKYGKVVRLGPRSISVSDPTAIFPVYNGRPSER (0) 1128448
PIFEHGDRIVFTQGSFTKSADIESSLMSKVDRRRSLDSAMR
1128625 YEGIIDQAANNLITSLRQRPLVRLTTLLQGFATEFINRLVLEESATQVMPFSAQGASCHW 1128804
1128805 YNRTGKWLKLPMIEYVLLRSPAARLKRRRGISFVPRKVQGGINGSQSSRAMNDGGISYNI 1128984
1128985 SLPRSYSNADGAYACIAMAFVSTFSSLLKHENVMTRLRSEIDTAFSKGLLSDPPRWQELG 1129164
1129165 KLRYLDAVIKESMRQLPSLGYNREVVTPPEGAIVAGYYIPPGTMMELHSEALRDDPGIYG 1129344
1129345 EDVHTYRPARWLTADLRQRWAMNQNLQQLSTSINDCPKVRVTWLELKKIVVLILLKFN (0) 1129518
LQLVRPGEGPIPSERSDQGLPPSMAYCTPRNH*
CYP5102A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000069.1
99% to CYP5102A1 Aspergillus oryzae
revised
27804 MVVCVITVLILGFLAFVRALCNYTRLSTVPGPLFTGLSDLWRTYARSTSDYGCSLAGLHM 27625
27624 KYGKVVRLGPRSISVSDPTAIFPVYNGRPSER (0) 27529
PIFEHGDRIVFTQGSFTKSTDIESSLMSKVDRRRSLESAMR
YEGIIDQAANNLITSLRQR 27296
27295 PLVRLTTLLQGFATEFINRLVLEESATQVMPFSAQGASCHWYNRTGKWLKLPMIEYALLR 27116
27115 SPAARLKRRRGISFVPRKVQGGINGSQSSRAMNDGGISYNISFPRSYSNADGAYACIAMA 26936
26935 FVSTFSSLLKHENVMTRLRSEIDTAFSKGLLSDPPRWQELGKLRYLDAVIKESMRQLPSL 26756
26755 GYNREVVTPPEGAIVAGYYIPPGTMMELHSEALRDDPGIYGEDVHTYRPARWLTADPRQR 26576
26575 WAMNQNLQQLSTSINDCPKVRVTWLELKKIVVLILLKFN (0)
LQLVRPGEGPIPSERSDQGSPPSMAYCTPRNH*
CYP5103A1P Aspergillus oryzae
GenEMBL BAE65635.1 AP007171.1
removed some seq
14 P450 genes and 2 pseudogenes on this contig
46% to AAGI01000167.1 Phaeosphaeria nodorum
37% to 54A1, 38% to 54B1, 39% to 54C1
revised 3/19/2009 & = frameshift
MEVQYILGILHNLDLAIWAVLIFIAFVLVTQAHYKAQLAKLPTFETDKGNEKWRRTYSDSARMLYQEGHKK (0)
FKDQAWIMPTSDGRKNVVVPGRLLSE
LSKLPETVLSFPTAINKVLEVKYTKVAPDEPFAPYCIK
ADLNPALSRLNPIIYREVENALEDEIPQCEDWTPVFIYRKLLNTVAKVSGRIFVGAELSHNKDYLDTAIN
YTIELGNAVQAVKQMKPWLRPFLAWKLPEVQQLNK
REEMAIRFLEPIIQARREASKDPD &
YQKPDDMLQWFLNRSEDYKVHS &
RRIVKMQLLVIFAGIHNTTVTATNVLYNLAVSPEYMQPLREEICKAISDNDGTLTSRALQQVEKLDSF
MKETIRFYP QNSLPSRAKR GQYIPPGTSIEAPLQAIYQDDSNYPDSDTFAGFRFYKIRQGGGATVHARNQ
FVTSNEQNLVFGYGKHACPGRFLAAAEIKMIVSKILLTYGFKNADNWTERYSNYEVGRL
NMPERAIPLLFRKTTAQDSSL
CYP5103A1P Aspergillus flavus
93% to CYP5103A1 Aspergillus oryzae
see fungal pages for seq.
CYP5103B1 Phaeosphaeria nodorum SN15
GenEMBL AAGI01000167.1
46% to CYP5103A1, 41% to 54A1 some gaps in seq
4489 MDVEKLAGLAYTFQTITIASLVFVVLTYAPKLMRRLQLAKLPSMPGKDYATS 4334
4333 ARKLYKEGHQKV (?) 4298
4170 SIGEHSVVVPPHFLPELRKLPDDVLSFAAAIDN (0) 4072
4025 VMETKFTGVDSEDSNTVHTIKSDLTPALPRLNQAVCTEVDAAMREALPSCEDWTEVDIN 3849
3848 DKLLDIISKVSGRVFVGPDLCHDPEYLELGRNYTVYLMEALFAIKRTRPWLKSFVGHRLP 3669
3668 EVKRLRDVEKKAIKFVQPIVRERLEAEKSDPNWQKPDDMMQWLINRYNKDGHVSVEHIAK 3489
3488 CQLGLILAASHTTTMTTTNILYTLVSTPEYVEPLREEIRNAMHGNGGSITTRALQEMVKL 3309
3308 DSYMKEVLRLYPAG (?)
3165 GQYLPPGATVQVPTAAIYTDSENYPDPDTFDGFRHSKLREGGTATDHSRNQFVTTNETNL 2986
2985 GFGYGRHACPGRFFAANEIKMIVARLILNYDMKMPGDATERYPNVDIGRSCIPCPGKTLM 2806
2805 FKRV* 2791
CYP5104A1P Aspergillus oryzae
GenEMBL BAE64914.1 AP007171.1
pseudogene just upstream of CYP5117A1 about 800bp, missing C-term
14 P450 genes and 2 pseudogenes on this contig
revised
MQQNMIIPSFWTGTAIIGLVACAYVSYQCLLSPLARFPGPFAAKLSKGWRAYKTANGQWHRKLVDLHRKY
GHVVRIAPNELSVGDPSSFRKIYSPAEAGNGFNKAACYSVVQGNRPFDLTGERNEKVHSEQRKLVATAYS
MSSMVHFESKVNVVIETVIHKLEARCRKTIDLGHWLQMWAFEPTRPLLNSLKPDVIGSVSFSQPFGYVES
GDDEGVFKRIQNAMGSAAWLMHAGWLFRLHQKLIPICGNWLAVNDRNGYFFQVACREVSGRINRGGDDKD
IIGQLLETQKIKPQLKDLDISFMMTSNVFAGSDSTSIAFQSIFYLLLTHPAAHDRLMRELREREEKGELS
DPVSFQEAESWPYLQAIIYEAMRLYAPAAFVLDRVVPPEGMMIEDKFVPGNTVVGSSAWVIHRNPEIWGP
DVDTFR
PERWLDDRKDEY (1)
KRYFFAFGGGSRTCIGK (1)
NISWLEIGK (0)
LVPTLLRHFEMRLENGAVLKEEFC (2)
ALVFLKGLKVHISRRRV*
CYP5104A2P Aspergillus terreus NIH2624
GenEMBL AAJN01000022.1
probable pseudogene 54% to CYP5104A1P
revised
MKLLALLLDSSAIATLLLA
68053 VTTGYVVYQVFFSPLAAFPGPFWAKVTYWYWAWRSMRGQAHRDLVNLHQRYGSVVRLGPD 68232
68233 YL (2) 68238
68297 ERGKSKSFQEIYS (?)
PEEAGGKFRKSAVHDTVTGTRPFDLLAQRDE 68476
68477 KIHSGQRRLVASAYTMDSIVYLEPMVDSLIVSTMEKLSTLPGDIDLGGWIQLFAF () 68641
68712 DVIGAISFSRPSGFIEAGDDGGIFRRMQNSLSSISWLMYVDWFYSLYQRLMPVIGNWLAA 68891
68892 NDRNGHFFNFARQEITARKDRAGNTKDMASQLFAVQHTKTELDDTNIAFMMASNVLAGSD 69071
69072 TTSTSARAVIYLLLKNPKSLQRLLDETEERKSDGRLSYPVKFQEAESWPYLQAVMYEAMR 69251
69252 LYPAVGRNLDRDVPAGGLRIGDHWVPEG (0)
TMVGSTAWAIHRIPEIWGPDVEDFRPERWL 69479
DEE*VGDL (1)
KRYFFAFGGGSRTCIGR (1) 69613
NISWLEISK (0)
FVPTLFMRFDVDLVPGTALEEFCG (2)
ALVFLSGPDVQLKLRPDFFNTAVKASTAT*
CYP5104A3 Aspergillus niger
JGI gene model e_gw1.9.635.1|Aspni1
58% to CYP5104A2P
see fungal pages for seq.
CYP5104A4 Hypocrea lixii
AJ896070 EST for C-term of CYP5104A
57% to CYP5104A1P Aspergillus oryzae
AAALELVDPPGCRNSAPARVLSKLRAELEERRAAGSLSRIVTFQEAEASPYLQAVMHEAS
RVFSPTGFNASRDVPKEGMMINGVFVPGGTVVGSNAWVIHRLPEVWGVDFEEFRPERWLE
RESSGELKRFFFAFGGGTRTCIGRNISWLEIGKLVATLVMRYDFQLVDEANITESYSGLV
FMKGLKVQLKSREA*
CYP5104B1 Aspergillus niger
JGI gene model e_gw1.3.2127.1|Aspni1
47% to CYP5104A2P
see fungal pages for seq.
CYP5104B2 Coccidioides immitis
53% to CYP5104B1
see fungal pages for seq.
CYP5104B3 Metarhizium anisopliae var. anisopliae Ma23
CYP5105A1 Aspergillus oryzae
GenEMBL BAE64645.1, AP007171.1
36% to 682B1 missing PKG motif, frameshift at YIL/PGT,
this restores the PKG motif, possible pseudogene
262325 MTLFQVVETSFILLALWTSVEAIRRLFSHSLSHIPGPRLAALTWWYEFYYDAVQSGQYVFKIQELHKQY (1) 262531
262599 GPIIRITPDEVHINDVGYLDTIYAPSMTRLDKYDYQLRTLRVPGGVGTTADYYLHRIRREALPPFFSKRNV
LWLESVITEKVNQLCGLIAKHAATETPVNLSDAFYGFSNY (2) 262931
VVNNFLFAHQTDVLADEQEAARLRHNSHEL
LKGINMNKHFPWIPDILEALPQLLTRPTMPPGLIDMLELFD (0)
RVRAELITIITRISSNTSGEKESINTGAK
GSVYESVLDSPNLPASEKALLRLEQEGALLTLAGTESPAQTLNIIFYHLLANPSLLTKLREELATLPTLS
TWTQLEQLPYLSAIIEEGNRLSFGVTARTARIQHTPITYTPSAYVTTPDPTHKSYIL 263721
263721 PGTPVSITTLSAHTAESVFPDPYAFLPERWLGD
EGRERRKFQLTFSRGGRKCLGIELARAELYLVTAALVRKFDLVLWETDERDVSFEHDYHVAMPRDGSRGV
RVVARIRGGLALSRDRLTTK 264089
CYP5105A1P Aspergillus flavus NRRL3357
GenEMBL AAIH01000184.1
pseudogene with 4 stops, 96% to 5105A1
38647 MTLFQVVETSFILLAL*TSVEAIRRLFSHSLSHIPGHRLAAFTWWYEFYYDAVQSGQYVF 38826
38827 KIQELHKQY (1) 38853
38921 GPIIRVTPDEVHINDVGYLDTIYAPSMTRLDKYDYQLRTLRVPGGVGTTADYYLHRIRRE 39100
39101 ALPPFFSKRNVLWLESVITEKVNQLCGLIAKHAATKTPVNL*DAFYGFSND (2) 39250
39309 VVNNF*FAHQTDVLADEQEAARLRHNSHELLKGINMNKHFPWIPDILEALPQLLTRPTMP 39488
39489 PGLIDMLELFD (0)
RVRAELTTIITRISSNTSGEKESINTGAKGS 39668
39669 VYESVLDSPNLPASEKALLRLEQEGALLTLAGTESPAQTLNIIFYHLLANPALLAKLREE 39848
39849 LATLPTLSTWTQLEQLPYLSAIIEEGNRLSFGVTARTARIQHTPITYTPSAYVTTPDPTH 40028
40029 KSYILPPGTPVSITTLSAHTAELVFLDPYAFLPERWLGDEGRERRKFQLAFSRGGRKCL 40205
40206 GVELARAELYLVTAALVRKFDLVLWETDERDVSFEHDYHVAMPRDGSTGVRVVARIR*GL 40385
40386 ALSRDRLTTK 40415
CYP5105A2P Botryotinia fuckeliana B05.10
GenEMBL AAID01002562.1
pseudogene 61% to CYP5105A1, 36% to 682B1
frameshift at KIQ, also after PIMP, one stop, runs off the end
1431 MAFAQLLGTGIILSLILTIAEATRRLYFHPLAHIPGPKLAALTWWYESYFDVIQPGQYVF 1252
1251 KIQ
NLHKQY (1)
GPILRNTPDELHIQDVGFLDTVYAPSASPRNKY 1072
1071 EYQLRTLRIPGGVRTTARYDLHKKRRAALSPFFSKRNVLHLEPLINKKVEQLYQMIDKHA 892
891 KEQSPAN*SDLLFAFSND (2)
VVTNFLFNHQVDVLSDETRAVELRH 712
711 NSHQLLMGININKHLPSIPDFSESLSLSISKPIMP
PGLIDMHAPFD (0)
519 RVRTELTDIMSSKPSEVSSEKLLGPTKKESVFASILDSAILPPTEKTLLRLQQEG 355
354 SLSVLAGTESPAQTLKIIFYHLLTNPAIIAKLRAELDTAPTPTSWATLEHLPYLSAVIDE 175
174 GNHLSFGVTARTARIADEQLTYTPSSHVTSTTNKGTFYKIPTGTPISITTLSAHTAET 1
CYP5105A3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_8000274|Aspni1
66% to CYP5105A1
see fungal pages for seq.
CYP5105B1 Mycosphaerella graminicola
43% to CYP5105A1 Aspergillus oryzae, 40% to 5105A3,
only 34% to 682A1 (next closest family)
see fungal pages for seq.
CYP5106A1 Aspergillus oryzae
GenEMBL BAE64452.1, BAE64451.1, AP007170.1
137250 MSFASALILVVAIWCIYVGWPWYRNWKQAKALHVPIVISPISTS
GAALQSLRYILDRDILPTWITRLAFVRLIQRNSRFQEKFAVHAEYGKLFILVTPATCE
LYVADVDAAKQVLSRWRDFPKPSSLLGMIFPERNA (1) 137663
GADWQRHRKLTARAFNEKLHEAVWAESTRNATKV
137909 MTKWNNTKPVYSTRSDMMALSLAVLFKACLNIDGDDKDDTRILAGDVAACQWHLDVVLKGISNPMALGRG
FEGIKKLKRSHKALGELLTEFVEARTIRPKLSAHADLLSSILAPTDHRGLSSDEVTGNLFLFMFAGHETT
ANALIYIIHLMAIFPAWQDWALEEIDQLSHNRADGEEVPSYSQILPQTQRLRAIL (0)
YETLRLYGPVPTLVRQTDPQAQTLVLPEQEVIIPKDTPVNVNTIALHTDPKQWGPDPLAWR
PDRWILQPCDSSLQKVSNELLKYLFAWGDGPRLCPGQRFSQIEVFAVLICFFKS
HRVELVPSRDQTMDQARSHALSLIQNSKVGLTLQMPDAESVGLRWVGR*
CYP5106A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000668.1
only one amino acid difference
see fungal pages for seq.
CYP5107A1 Aspergillus oryzae
GenEMBL BAE63455.1 AP007167.1
42% to 5107B1
601589 MIGEQYTSIITGFKSALAVSCIAVSLFLLSPWIAYARLPSSIKSPIKAKGPLSALRACLNEISAGAKTST
RGYELY (0)
SKKGQSFAMLNINFRPQVILPPEHVRWLVTQPEDILSHAKASDDADALGYIWPLFDASALHSFS
KVLQIDLTRNVTQTEKDVLEEVQHIMDELVGQTESWKEVNMVQAFERIMYQATQRVYVGLPLCRDSTYMG
YVKGYARSLGTAMVFAAQLTPWPLRQVTALLAGLPVYYYVLRVRSYLSPLFKERMERLKEKGGTQDDNLE
GEPRNLITWMSNGVLSGVGPKSISPSEMVTWLGIL (?)
602662 ALLPTDNLWTTCTNVLLDLLSSESEHAYLHTIREE
ARTVFASSKESGKPVSHGLHHIDSAIRESLRMNSLSPRSLHRQVVRRGGVVLPDGQKVPTGTWLCVLSGN
IQRDEDYYEDAQTYKPFRFVPKLTEAGGDKAPLLPLTNEKYLTFGYGRHAC (2) PGRWFSFQVMKIVIAYILA
NYDIQPLEKRPDNIVFADLNIPHLSHIIRIKRMT 603339
CYP5107A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000006.1
only one amino acid difference
complement (71337-73087)
see fungal pages for seq.
CYP5071B1P Aspergillus oryzae
GenEMBL BAE63454.1
heme signature incomplete
only 679bp from CYP5107A1 pointing away from each other
42% to 5107A1
one stop codon, possible pseudogene or seq error.
600910 MQIADMAASTTAQILVVSLGLLIFVLLCPWFGYLRLPSSMRWWPSIPSGPLSALRLSLKEYSGSRSSENG
YKAFSKKAEPFAICNPSFYPQVLLPPEQIPWLLSQPENVLSHEKANEDVHALPFLAPAFDNYDHLELIRA
IRTDLTRNIPNTEDAFLDELRHTTNEVLGAPGDNAWKEVNLTVALDSIIFGICLRLFFGVSLSRNRTFVY
YVKIFTRVTGAMMLFVSQLVPWPLKPVVGIVAGFPIYYYWVRLIIYLYPTFKERIQCLRTKKETPPADMV
TWMVDLAISQNPTRKVHISSLIVRLTLININVRLTRSSKVFLPVDVLIAMTDNFFLDLLSSDPDRKYYNA
LRQEAEAAFTNRDKTQPISQSMPYMESTIRESLRLSPLSDRMLSRRVVHKGGITLPDGQFLPRGTWLAVA
AVGVHRDERTYEDPDEYRPFRFLSEDTETKEAKAMLVPVTSEKFLAFGHGRHSC (2) 599384
599313 PGR*FAAHAMKLIIGYILVNYDIEP
LEKRPVNSVVGQTIIPQLDVKIRVRRRE 599155
CYP5107B1 Aspergillus flavus
99% to CYP5107B1 Aspergillus oryzae
see fungal pages for seq.
CYP5108A1 Aspergillus oryzae
GenEMBL BAE63248.1, AP007166.1
all the best hits are CYP51
but at low 20% range, revised at N-term
1834519 MLEALLFRPSLLSFISAWLGTLGLALLLFSSRRASTKLPPRANGGIYFI
SDILVFLASPVQFVKQATGKHGSVFRIDCLVKQIFYLRGQKWNRFFLEMK
EDTWSFSGGI (0)
1834137
GMFLNKAANPGYFTHGRNLLGSINRGVNRSAALQSYGRLAGEEAHKSLQHWSQMPDVEIFESISRFVHRVI
VRCMMGEDFYDHHVDELYDLLQQMESLVGHPFNLLLPSWVPHLPGRQLAQARNRFAEIFRERLAARQLES
DVWRDSLDYINYTLNDPRTAQLADYYPSHHVVLMFAAHTSTVASIAWTIVE (0)
1833514 LLRHPIYQEEIRESLATMSDIHQCAPLLACLREEG
RRYSGVHMFRTTKQPVSLEGSDYTVPEKSVVLISPYLTHHDPAIYPEPHEYQP
HRWLLPDGRLNPWNGSKEAAFLQFGAGNHRCPGENFAAIIAREFLAALLMKYEIEWGRDGAPADLSRLDF
TKVGSPWLEGDAAVRIRPRVFGS 1832966
CYP5108A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000996.1
99% (4 aa diffs) to CYP5108A1 Aspergillus oryzae
6424 MLEALLFRPSLLSFIAAWLGTLGLALLLFSSRRASTKLPPRANGGIYFISDILVFLASPV 6603
6604 QFVKQATGKHGSVFRIDCLVKQIFYLRGQKWNRFFLEMKEDTWSFSGGI 6750
6806 GMFLNKAANPGYFTHGRNLLGSINRGVNRSAALQSYGRLAGEEAHKSLQHWSQMPDVEIF 6985
6986 ESISRFVHRVIVRCMMGEDFYDHHVDELYDLLQQMESLVGHPFNLLLPSWVPHLPGRQLA 7165
7166 QARNRFAEIFRERLAARQLESDVWRDSLDYINYTLNDPRTAQLADYYPSHHVVLMFAAHT 7345
7346 STVASIAWTIVE (0)
LLRHPIYQEEIRESLATTSDIHQCAPLLACLREEG
7540 RRYSGVHMFRTTKRPVSLEGSDYTVPEKSVVLISPYLTHHDPAIYPEPHEYQPHRWLLPD 7719
7720 GRLNPWNGSKEAAFLQFGAGNHRCPGENFAAIIAREFLAALLMKYAIEWGRDGAPADLSR 7899
7900 LDFTKVGSPWLEGDAAVRIRPRVFGS 7977
CYP5108A2 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_10000032|Aspni1
57% to CYP5108A1
see fungal pages for seq.
CYP5108A3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_4000032|Aspni1
54% to CYP5108A1
see fungal pages for seq.
CYP5108B1 Aspergillus terreus NIH2624
GenEMBL AAJN01000021.1
43% to CYP5108A1
MLTQELQAIYANNAGFLITSL
70767 LAFALLALAVRSFLRSEKIPLVSAGLPILGNLQKYSLDPVGFIASATRLHGECFAVPML 70943
70944 FGRTIWLRSPQLNKEYLETRE (0)
DVWSFGDGMGLFLNKIVIPGYF 71123
71124 SHLRSMVGSLSRGISRKATLEYYAQVADEETAKAVDGWTCKSEAEKSVALFEEISFLVHK 71303
71304 IIVRCLMGQDFYDHHVRELYDLLRTMEANVGSIWHTVLPGWVAHGPARRLWRCRQRVQEI 71483
71484 FDFRLRERERSPEEWKKRLDYISYTLQDPATAHLSRFYGAHHTLLMFAAHTSTVASISWI 71663
71664 LLE (0) 71672
LLRSPHRLQRLREELATHALEQSPFLDALVKETG
71834 RHYSGNSDVRWARKPKTLRTEVASVPESRITIPEGTIVSISPYLTHHDPATWDNADTYLP 72013
72014 ERWLADPDLAKKMNEGGQLRYIPFGAGSHRCPGEKMAILIAKIAVARIVQSCDLAWGEGS 72193
72194 SENTLGGLDFSKVGSPWLKGDVQVRFQ 72274
CYP5108C1 Metarhizium anisopliae var. acridum Ma102
CYP5108C1 Metarhizium anisopliae var. anisopliae Ma23
CYP5109A1 Aspergillus oryzae
GenEMBL BAE63087.1, AP007166.1
36% to 573A2
revised 3/15/2009
1411903 MSPFIFAVTLTFAILALGILRRRYFHPLSRFPGPFLGSVTSLYQTYWHVHPNKTLHDTELHKKYGPIVRY
SPNGLIVNDPALLPVIYNRRANKTDFYAPVFDTHSTFTRKDYREHVASRKAISHAYSVTNTRLFEPQVDG
ILSELISLLSESATEKRLVDIMEYGS (2)
WFTYDVTSLFVCGKPFGFVEKRTDVKGLIQNKNKVLFIIFIMTIQEN
LSWIVRNTRLGRRYLMPHPTDQSGLGVVMAERDRIVDAVIDNDGKVKRHLLVKGSLLSSLMEILGTEGCP
LSLVDVKAEIFFAMLAGSSVTPSQLARVIFHISRNFKVQEKLYEELVAAEQDGRIPPLSAIISDEQAHRL
PFLSACIREAQRYAPTMSQLPRYAPEGTGLELHEQYVPPGTSVSTSPWIIGRNKDLYGEDANSFRPERWL
EASPEEERRWDHFSFHFGYGARKCLANNFGLMQLYKVAAEVFRRFEVKVEGSNEDTVSGGPPASARFRFD
RRARSWS 1413728
CYP5109A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01001109.1
4670-6495, only 3 aa diffs
see fungal pages for seq.
CYP5110A1 Aspergillus oryzae
GenEMBL BAE58993.1 AP007157.1
gene model revised
1141014 MAIQSTLEMCHLAESGVYLILVTFGVGLLFGLIVLTSDYLDGWLRRRALGDIPFVDEGSN 1140835
1140834 MSACLRWWSRKFDCDKEYAEAYKQ (0) 1140763
1140699 YSKTGKPYATRLKNNDHGIVLPLNSTKEWRTLPHDQLSFLHALSE (0) 1140565
1140509 FADLYMHTNITDRTPLHAVHYCNNTKTL (1)
SRFNRLMVDATDRALPLIVGKDTES (1)
EWKRANAFHTILSLCSTVAMSVLLGPEFSMDTSLIQTIM
MYNTAIMPSCAK
RTSYPRILRPFVWRLSPLCRAVKSDLLKTKIKLIPEIKHRIDIARSKKWWLEEGPMSLLDGLIETAFEKG
CLSRSSDRGDDDQQVALLAEEIIFYHFELSMPVVFFIIFAVYVIMNNKEYLTPLREEISEALKLSGGSFT
LDTLNHAPKLASFVKETCRLYDISCCN (2)
FRRVMKPIHLESINLSLKPGTIIMAPGRDVHLDPDYYDNPTTFNGYRFYD
ASRGTCTPHISTTSPTFLTFSHGISACPARVLATQITRTIFIMFLLKFDVELAHEEMPAYGFANGPAYLP
NPSVMIRVRPCQKDVLGV 1139078
CYP5110A1 Aspergillus flavus
97% to CYP5110A1 Aspergillus oryzae
see fungal pages for seq.
CYP5110A2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000022.1
55% to CYP5110A1
MAVQASSSIHHLADLGTSAALTGVVLVLLCGLLIVISDYLDGWQQRRALKGIPIVDEG
SYMRPLLRWKRFDAAKEYARAYHL (0)
YSKNGQPYATRLQNDDYGIVMPLNSAKEWRALPHEELSFLHALAE (0)
FVDMNLYSDVTDRTPIQAVHSCNNTQSL (1)
NHLNKLLVRNIDNVLPSIFKQPTQD (1)
165619 KWLEVNTFQTIMSLCSTVTMSLLLGPDTPYDPVLHHHVSSFGAAIMESCYGRTAYPRILR 165798
165799 PFAWRFSPQCRGLRTHLSMARARLIPEVARRVAAARKANIEVKDSRPTSLLDALIEAALE 165978
165979 NGSLNRDGICTNEKAQLQILADDLLFFHFELSKPTTVNIVFQMYAIMNHREYMSPLREEI 166158
166159 TKALELTNGEWTVETLKYAPKLESFTKETFRLYDISPCN (2) 166275
166335 FRRVMKPVTLKSIDLSLRPGTILVSPCRDIHQDPDFYENPMTFDGYRFYDTNSNACTPRV 166514
166515 ATTSLTFLSFSHGTGSCPARVLASQICRTIFIKFLVEYDVELANKKMPAYGFTNGPVFLP 166694
166695 NPEVMMRIRPRGNGMQ* 166745
CYP5110A3 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_22000006|Aspni1
71% to CYP5110A2
see fungal pages for seq.
CYP5111A1 Aspergillus oryzae
GenEMBL BAE58483.1, AP007155.1
Note: a 6 bp micro exon matches known mRNA EY432550.1
3848877 MLQDLIATLASGAQMYWASSGVWMRVVLTVSAIWIFWRIWRFTILPLFRPNEPVELPYWIP (1)
YF (1)
GHAGAFFKDSHQLIRTAL (2)
KRFGTLEPFSMIIAGDRYYVITSPEDTRPFFADVKAMTTDGFLDRALL
AFGCAPERLHTLWQRNTPTKVNPKGKNLIHLTQDLFKHDLVPGPTLNVLLERYQGALDELLSWDRLVGAY
PSLVSTQTEAISLYDICADFIANANQIVLFDRALLAIDPDMAVEMRTFTDELWKLVHRSRLVDTTEVTRI
LRQYSSAFKSYLQLPPEARPNETPVIRTLLETYAELGIHEDDRAAMLVMICWAGDANAYKAAYWVLAYIL
YDPQLREIIRQETAPAVGPDGKLDWPYLAKRCPRLSSIYHEVLRLTKRDVIVRQVVRDTALAGKRLRKDS
IAVIPTCQLHDNPDTYGADAASFNPDRFLKQPGLAQTTFFPYGGGRHYCPGRYFVEMEIYGLVALMLNRY
EMDLAWAAPFPRRDESLVTLGISRPVPGDDLHVTLNWKEGNKN 3850672
CYP5111A1 Aspergillus flavus
100% to CYP5111A1 Aspergillus oryzae
see fungal pages for seq.
CYP5112A1 Aspergillus oryzae
GenEMBL BAE57727.1, AP007155.1
35% to 551A1, 34% to 551B1, 32% to 551A2
1498000 MNTSLDSSTALGFYITLTVVTISVAYVSILALCRLFLSPIAVFPGPPLARLTYLTQWYYDWVKDGQYYLQ
IEEMHKKYGPIVRVTPGELHIRDSNFHSKLYVTGAVRKSDSYHRFTQGTGFEDITFPLLSHDRHRALRGQ
VSRLFTRAGVRQHESRIVARIHVLSQRMCGFMSNGKPVNLHDAFSSLAAGMYNAISVIFHEEPTDYLGDP
EFNTAWYNTLKMGTATIPLLTQLPWLARVISAPVARYILERATPWRIFDDKSRRQMLKSKSRPTIASSDR
SNATVFDNLFKDNLFYTMNEQTFTRSAQ (0) 1496760
LIQQGAVHNVSLSLAMTIYCLLCQPDEQEKLTRELESSFSKYPERSPSFSELESLPHLSACIKEGLR ()
LSVGALVGIPRVSPDVDLVFDTYTIPKG ()
TPVSMTPHWMHMDPDVFPNPNSFDPSRWSSTLTEPEKLSLMGRYFVPFGKGSRSCIG ()
TRLAYLLLYQTLAHLFRPGAPRLLLHETDISDVTPVRGFLFSL
PKKDSKGLRVILVNDSESTNRM* 1495794
CYP5112A1P Aspergillus flavus
97% to CYP5112A1 Aspergillus oryzae
NTSLDSSTALGFYITLTVVTISVAYVSILA
TPVSMTPH*MHMDPDVFPNPNSFEPSRWSSTLTEPEKLSLMGRYFVPFGKGSRSCI
GTRLAYLLLYQTLAHLFRPGAPRLLLHETDISDVTPVRGFLFSL
PKEDSKGLRVIL
CYP5113A1 Aspergillus oryzae
GenEMBL BAE62292.1 AP007164.1
Revised model
only top part = P450 C-term,
36% to 584E1, 36% to 584A1 , 35% to 584B1
35% to 584C1, 40% to 584E5, 38% to 584G1, 32% to 584D1,
32% to 584D2, 41% to 584E3
revised, gc boundary at CVG
MTAETGFVPTVFSLPSESAYSWVW
AVSAGLVAIFVLYLTQGIARRRFAYAHGCQAPPRYAHRDPILGLDSLRDSMQAR
KSDRYFRREQQLHQAYGNTFMSLLLGSWMVNTIEPKNLEVLFSTKFADYEVGFRRRNAFA
PLFGKSIFQSDGTRWQTLRSQLQLCFSRVQTSQLGLLESHCQRLLAALPSDNQKFDLALF
LHRFAADVSTDFLFGESINSLENPQNLDGGALKAFADTHSTCELRWLLGSMSWIWP
QRTFMKNVRLTHRFIQRYVDAALEREVTPPGKASDQQNEQRILFIDQLRQRTQDPIALR
DELTTLYFAGTDAPAALLINLFFVFSKRPDVWDRVRSEVQSLGGKAPDLQQLKGLRYVQD
CIREC (1)
LRLYPPQ
1582777 PSNSRVAVRDTVLPTGGGPDGGSPVLVPKGMMVHLSVYALHHRKDLWGEDADEFRPERWSYEKQTW (0) 1582974
1583043 KYIPFLGGPRNCVG (1) 1583087
MDFGLNEVAYAVVRMAQNFQTITSVDPDEWVEGSSIALESKNGVKVVMCRDA*
CYP5113A1 Aspergillus flavus
99% to CYP5113A1 Aspergillus oryzae
see fungal pages for seq.
CYP5114A1 Aspergillus oryzae
GenEMBL BAE63475.1, AP007167.1
33% to 548D2, 33% to 548E2, 35% to 548F1, 37% to 548G1,
38% to 548A6, 41% to CYP548H1
657999 MELPIRYCLGISLAVAGVAFCLYQMFFHPLAKYPGPTLAKFTAARAAYCAWKDDVHLDIWLCRKKYGPII
RYVPNHLCFDTVTGLKDIYLSGKDLRKDKIMGKASFVPNLLTIMDRKEHARHRRLIGIGFSQSAMKSVNE
RLLHHVKSFYHVAYNAGLPDEANGWSHPLTMSDLCSYLTFNVMADFIYGKSYDLIHCPDYRHLLEHIEES
NLRTGVLLYCPQLYIGRLDRKLFPRASTGNKTIHSFINQIIQERKSENGVGQSIYEQLGTQRKSTDHPLT
PEEIRSEAMLLTIAGNDTTSTALCAALFYLGKNLHAYEKLAAEIRTKFSVVDGIGQDETLRNCHYLHACT
YESLRMSPPVGSSMWREVGPGGTSIDGEFIPCGYGVGTGIYSIHHNPKYFPRPHDFIPERWLSEKDGFIC
KEQADIPFAAYILFSAGTRACLGRHLAITELLTTIAALVLLYDFRISHTENGELGCGHALGRHGRTNPGE
FQLYHRVTSGKEGPILQLRPRKGN 656192
CYP5114A1 Aspergillus flavus
100% to CYP5114A1 Aspergillus oryzae
see fungal pages for seq.
CYP5115A1X Phaeosphaeria nodorum SN15
GenEMBL AAGI01000308.1
Name changed to CYP548K1
CYP5116A1 Aspergillus oryzae
GenEMBL BAE54596.1 AP007150.1
This P450 is unlike any other, very low seq similarity
240943
MSLFLVIVVVLLLFLSSPLHRLVHIGLKKPVSPNIDPETYRRIIEGKGLYQEVHNQLNARQSRAIPNKRL
RAVFGIENALTTDNEIHAKRFLRQVKGLINLSPTSWESLSGLVRSAARRSIDGA
MANSPDKPRVMLTNLV
QVLVLRVVLSVLFRMETEALEVPDHDLLRLAEAINDAWTSSKDKTHLVSFQDNISLQNSLKTVF
PHLNCLDPQGNPLNLVIPGFETMWRIVLRLFIEISYTSGLYHPEWRGIMTTFAIAPTKDEFERRNGKQNLSAEMLV
NEALRLYPPTKRVYRAFLPVGSDTVEVLNADIEKAQTATHIWGSDAEVFAPGRWGALTPQQKLAFF
PFGSKPFVCPAQAAFGPRAIALVVGALLVELGGEWSLCVGAECTEALVPGVRLSNQRTEYRDLCLARAGPV 242193
CYP5116A1 Aspergillus flavus
99% to CYP5116A1 Aspergillus oryzae
see fungal pages for seq.
CYP5116B1 Aspergillus nidulans FGSC A4
GenEMBL AACD01000061.1
New, not in known collection
37% to 5116A1
363827 MTARSMASTVSLYLILFVLFVLFYRRCYRSSKKPAEFRTTAECRAIIDGSQFPDARKNQLTRL 363639
363638 EARALPNQPLIGAFGIKNAFTTGNEAEAKDFVENVRRLIEVSAVDWHGLAGALQCMLESI 363459
363458 IEENRDGARVKVSLTPTVQALVLRESFWILFQMGEDAHLEFKQLADLGKITNS 363300
363299 TWVRMKEERALEFKDNIVLQACLTAVFANHKTDINILDPGSNPLKLILPSFETVWRIVL 363123
363122 RLFIVLHCHDNEDYKRALLEFVRDPTLTQFRLRPDNAVSVEFLVKEALRLYPPTRR 362955
362954 IRRAFQFPGSSPNNQISNIGRANVEACHLNEEVWGPDALEFMPARWSKMSSVQRRSFLAF 362775
362774 GGPPFLCPASHAFGPMVIGLLAGVMLDVFGKMNGYGKEWVLGSDDERDMSEVHSRERLRN 362595
362594 ERDAYGGLFLDLYSRRIDVSS*
CYP5116C1 Trichophyton rubrum CHUV862.00
GenEMBL AJ883817.1 AJ883817 cDNA
45% to CYP5116B1, 45% TO CYP5116A1
STSTRHSSHHKCGTS
913 VVLTXFYAXLQTDVDKTQYKDVLKLAEDINRIWISSKSPDEEKRSSYQSETPFHDTLKAI 734
733 FPNTQISSPASNPLNLILPSFETMWRIVLRTFLEINFLTGNRSPEFKQVLVEFFHNPTKE 554
553 QFNQELSPGVSASNVISEALRLFPPTRRVHRHFQGLSSNERTLFAADIEACHRNLRVWG 377
376 SDALKFVPGRWNCLNEQQKSSFMPFGSKPFLCPAKPVFGPRMIALLVGALLCHYTENWEL 197
SSVSGKYGINMVAEGEYLDRDACAQLYLVRDIRV*
CYP5117A1 Aspergillus oryzae
GenEMBL BAE64915.1, AP007171.1
40% to 65E1
14 P450 genes and 2 pseudogenes on this contig
MNSISALFSAGGFQWILLSLSLAFIVVYSLFYLAVGLYNLYFHPLARYPGPLLGRASSLWYARSLARGTV
AQDTLKLHEKYGDVVRIAPDELSFIQPENWSAIYGHQLGKDYRELIKDPRYHDTVKPTPTILTGDWDEHT
FYRKILSNSFSEKSLKDQEHILHHFVDLFVQRLKETSAEGTRELNMTDQWNYLTFDVIGFLTYGEEFHCL
TSSKLHDWIEAMLCVAILMSLGQAARHLPFPFDKIYKQWAIPSNVKRQVALHRDLTEVAIPHIPIQYASA
YRLNSRKGDIPYSVLKEHANILTIGGSETTATLLAGATFHLGKNPPVLQKLATEIRTTFVNDGEITVARL
SECKYLLATVEECLRIYPPSPANHTRMVPKEGIVLNDQHIPGGIGVGMPMYAAFRASSNFTYPDRFAPER
WLGDPMYSKDKKGALQPFSFGPRNCLGRHLAYQEIKLALAKLVYHFDLELNPKCGDWDEQKNFTFWVKPP
LWVNLHPVKS
CYP5117A2P Aspergillus clavatus
Pseudogene fragment
63% to 5117A1
(+) strand I-helix to EXXR motif
adjacent to a CYP68Q seq on the (-) strand
GATFYLATNTAIFPKLASEIRGTFASDEEITVARASKCNYLAATIEECLRMYPPT
CYP5118A1X Aspergillus oryzae
GenEMBL BAE63025.1
39% to 65S2
renamed CYP65AZ1
MFVLPTTFMSVSHGIYQLLFLALLATAWRIYSNRFRHPLSHYPGPFFWTISRLPYAVTYAQGTLHRRVRQ
LHDVYGDVVRVAPDELSYRTEQAWKDIHGYSRNFPKDMRFYQTSKNKAPSVVIAPDGVHGRQKRSILRAF
SERAMKSHEHLLRPFVDSLIQKLQHASTSTEGGAVDLTEWYNYIMFDFMAHELFGQSLGCLENGVNHPWV
DMLFGSIKVWAFLSQSKYFPNLSWIIKTAVRLFCRDLLNHRSKKLGCIASKIPEGEGSDSSLPTFNSFLR
ANKGPHSTLSTEEVLSNHSFMMMAGSETTATLLSGCTFFLLKHPQVYKKLTSEIRNRFSSSTEMTFSSLA
NMAYLRAVLQEALRMYPPLPLGMPRVVPPGGAIISGQFVPEKTSVAVASWATYQSSSNFNTPQMFLPERW
LDTGPGDNDVKGAMQPFSVGPRACPGKNLAFGEASLILARLIWEFDLELSPQCSSWAYQRAYIIWDKGPL
LIKLTPRI
CYP5119A1 Aspergillus oryzae
GenEMBL BAE60008.1
35% to 5068A1, 34% to 5068A2
39% to 5068B1
MLPTLPNIAGRINTMATFLLPVAIGTIILLFLYGKYVTSTLIPGPPTLPLIGNLHQLPSDDRRHVLAQWH
KKHGPIISLKFGWSSVVILGNIAVTKELFGKRSLKYGSRPRMVMARDCMTKQMQTSTLPWGEKWKIHNRI
QLSLVGGPKIRSYQSLLDIESCKVLYQLLSTESLVTCFNRFKFNIIYTLAYGKDPDQNESDFHEILELAD
HFTQTLTNATWVVDLFPILNCLPRRLAPWKAVGDDFHRRAMGWFRRNSEAAVKSNSWNWTKHVQFNEDTG
NLSVSEMQYLIGVLFEAGVDSTATVLHFFVLACTLYPDAVTKARQELDKVVGSARLPTPKDLPQLPYVKA
FIQEVLRWRPITAEGLPHFTLEDDKYQGYDIPKGSTVIFNYWSGHMDEDTYQHADQFCPERWIERPDLPL
GVFGYGRRACAGRRLALMSLETLIPKLLWAFDFRSPAGTDHGKSRDPGTEHQGALIKPRSFPVSWHPVSN
DRRLIIERLFQERDKDLDTVLDDIGKAFERY
CYP5120A1 Aspergillus terreus NIH2624
GenEMBL AAJN01000022.1
36% to CYP5102A1
this p450 belongs to a group of sequences without
Cys at heme region CYP5102, CYP5120, CYP5121 families
Not included in the Cytochrome P450 database in Korea 3/24/2009
33059 MVTLAIVVLFVLIASIRLLYNHVRLNTIPGPVLAGLSSFWLHAQPSSQLPNSLLQLHE 33232
33233 KYGTIVRIGPDLVSVSNPATIVLIYTRRSRNR (0) 33328
33462 YEGLVDPALRNLVHTLRRYQTLDLASFLHFFAADFLSRLTTLHPAGANNA 33611
33612 RRHEPTERGLPGFFAECLLLRGPISRLKRQHGCPFICREVRSHFTGQPTSISSRTLFK 33785
33786 SEDHPSPMEEHLDCIAKTFVSTFRFLLKYPAVMRKLRREIVAAHNHNNLSPLPLW 33950
33951 SELGELKYLQAVMKESLRLSHVHRVHEVKSPAGGVTVSGYYVPQGTTIRCHPLVVHNNA 34127
34128 QIYGDRPQVFDPERWLNNDLQRQKCMTECLMLFQQHVFENPTIYAAWWELKKAIVVVLMW 34307
34308 FN (0)
LELCTAYEAAQDSGTGSNPPVVVRFIPRS*
CYP5120B1 Aspergillus nidulans FGSC A4
GenEMBL AACD01000093.1 new not in known set
this p450 belongs to a group of sequences without
Cys at heme region CYP5102, CYP5120, CYP5121 families
weakly similar to CYP532
38% to CYP5120A1
MVAWA
214086 VLLLAVVAATLLHLLYNYSRLKSVSGPILAAFTDAWRANAQRSSSSSEYGRLLKELHRKY 213907
213906 GVAVRLGPGFVSLSEVGDITRVYHTLLQDE (0)
213711 YESAADTAMRNLVHTVRRCRTVDMTTLLHFFADEVNTRLFWSACA 213577
213576 PSAASSASSRTHRIQPSFSFFATIEELVLRGPVALLKRERLSCYCLSGDVSAKIYGNE 213403
213402 LVLPTGPSATRKLAISAPDGLILAASIQIITKAFVSVFFFLLNNPLIMRRLR 213247
213246 QEIESIPRFRNRTKLPSSRDLGGLYYLDAVFKETMRLVILQSQPMEVRVTFESLYISSKH 213067
213066 VPRGTVLSWHPHVVLTNDAIYENNLYVFRPERWLTPNRQRQTLMEASLLPFMVCRIHYPK 212887
212886 LEAAWLLLKKTVVVLLREFCD (0) 212824
INLTQTEGQTVADGMELPPWSMVVDFIPRPATAEEYVGQLL*
CYP5121A1 Neosartorya fischeri NRRL 181
GenEMBL AAKE02000008.1
42% to AAKD02000042.1 Aspergillus clavatus
this p450 belongs to a group of sequences without
Cys at heme region CYP5102, CYP5120, CYP5121 families
1210404 MAVFAALLLLLCVFGGILWNYTRLNTIPGPLLAGLSDIWSQCLKSSPRYAYRLQRLHRKY 1210583
1210584 GEVVRIGPKTVSVTDPSNIFWLDAACPQRSK (0) 1210676
1210852 DLVLDFLKAIRKQRTMKLTVFRDFATDIVGRMFVGDLEDDRAAPMRTGSNQMDRCRFTTS 1211031
1211032 LDHIMFKNPVAKLKRKRNKSLRWVSCAVTHSRWDDASIFEVLPETGRKTFLQ 1211187
1211188 AETREYGGPYASLIVKGADCMVAAFVSVFRHLLKCPTAMSQLQHEVDNAFRNLTLSD 1211358
1211359 ILQQETELHALSFLDAVIKESMRLALRFDYLRDVPAGGLAVLGHYLPEGTVVQFHSEA 1211532
1211533 LRNNRTIFGEDVSDFRPQRWLQADLDQWQRKQMEALLFLRPNMPNSAKARAAWLELKRA 1211709
1211710 AALIILKFD (0) 1211736
1211784 LRPLNYEEVFIQDAVSREQEYEILVNFTPRMH* 1211882
CYP5121A1 Aspergillus fumigatus Af293
GenEMBL AAHF01000006.1
85% to CYP5121A1
this p450 belongs to a group of sequences without
Cys at heme region CYP5102, CYP5120, CYP5121 families
Name changed from CYP5121A2
2336635 MAVFAALLLILCVFGGILWNYTRLNTLPGPLLAVLSDIWSQCFKLSPGYAYRLERLH 2336805
2336806 RKYGEVVRIGPKTVSVSD 2336859
PSIVFWLDAACPQRSK (0)
NLVL
2337098 NFLRAIRRQHTMKLTVFRNFATDIVGRMFVGDLGDDRAAPIGTRSNHIDRCRFTTSLD 2337271
2337272 HIMFKSPVAKLKRKRNKGLRWISCAGTYSRWNDASIVDVLPETGRKTILQAETRE 2337436
2337437 YDGPYDSLIVNGADCMAAAFVSMFRHLFKCPTAMFQLQDEVDNAFRNLTISDVLHQET 2337610
2337611 ELHALPFLDAVMKESMRLAMKFDYRRAVPAGGLAVLGHYVPERTVVQFHSEALRNNRT 2337784
2337785 TFGEDVSDFRPQRWLQADLDQWQRTRMEEALLFLRPNIPNSAEARAAWLELKRAAALIIW 2337964
2337965 KFD (0)
2338021 LHPLNYEEVFIQDAVSPEQEYEIMVNFTPRMH* 2338119
CYP5121B1 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000042.1
42% to AAKE02000008.1 Neosartorya fischeri
this p450 belongs to a group of sequences without
Cys at heme region CYP5102, CYP5120, CYP5121 families
MAAFG
82938 ILLSAVLVLGGVLLRNYVSLNTVRGPLLAGISNLWREFLQSAPEYGRRLESLHRKY 83105
83106 GQVVRVGPNTVSVSDPSLVAWIDLSDRGTVN (0) 83162
QLTSTFLRAVRKQRTINLAVFKLFAADIVQHM 83430
83431 CSNDIIQPRASQVPFATDPFIPTESSYVSSFLNSLLLKCPIAMLKHKRNGCLPI 83592
83593 CGFVPESVKRPNAYQPVAGEYQRSGNVSLVAIGVECMEATFASVFYFLSTH 83745
83746 PATLSRIKREIDTIFSMASFSEVLHQTKSYALPYVEAVMKETLRHVMIFDYQHQVPPG 83919
83920 GVMVGEYDLPQGTVIQYHADTIRHNSTTYGEDSALFRPERWLLADTTERKRMEEGLIPLR 84099
84100 ICFRNDSQTRAAWRSLKMIIALVISKFD (0) 84183
LQLSCEETPDNTSSTMSCNVLVTFAPRLP*
CYP5122A1 Trypanosoma brucei
GenEMBL XM_819043
N-term to I-helix about 41% identical to
Chlamydomonas CYP745A1
MAVITNTSSLNGGFVSGSFMFLNDIFLYYSTSDLIWVGFMSMLMFIIMLWLSNVVVPAIR
MDRYLANIPRAPGGLPVLGHALELLEGSPSSKMASWSLRPWKAKRENTVAVTKAGTNRIV
AFTVFSQRVVYINEPALIKRVLLSNQRNYTKDIASSYKHFMCLLGNGLVTAEGHKWRKGR
LMLSHSLRIDILEDMPEMTMRAVGRIMEKLRTVGSGVPFLDLNEEFRHLTLQVIGETVLS
LSAEETDRIFPTLYLPIVHECNRRVWEPWRAFMFFSDGFRERRRCLKRLNAVICDIIQER
WRQRNEGSQKDVMSLCLSQVDALDNNMLLQLRDDVKTLLLAGHETSAALLTWATYEVICH
PEIRDKVVEEAKALFDP AHCDRTMETPEGVWGIPSASAVRSSLRWTPAVLRETLRKHSVV
PLVMRVAVNNDKWPASETGLDKDVVIPAGCSVAVGIEGVHQRPDIWEDPGSFNPERFLDV
AIPNDTNSPPTGEKYEKRIDPYAFIPFIN GPRNCLGQHLSMMETQVALAYLFLNWDLQLH
GAVSQSDTEINKELQQEVGRPHKFLIPIVPGNGLKVVGHPRPRY*
CYP5122A1 Trypanosoma cruzi
gnl|TIGR_5693|1047053509719
63% to T. brucei CYP5122A1
MGILIVIWALILYYFFLFLRGFIMDRHLRNIPEAPGRIPVVGHALILMGGS
PWRKMADWSLDSFSHADSNKKKDT
PRTSRLVRFNVLYQRVVYINDPLLLKRVLLTNQRNYAKDVETSYKHFLCLLGTGLVTAEG
EHWKKGRLLLSHAMRIDVLEEVPKMTIKAVGRVMDQIAAIDDKNPFVDLNEAFRHMTLQV
IGETTLSLEPEETDRIFPALYLPVVHECNRRVWEPWRAVMPFLEGFQERRRCLKELNHVI
CELILKRWEDRHKPHKRDIISLCISQIDKMDNAMVVQLRDDVKTILLAGHETSAALLTWA
TYEVISRPDACEKIVEEARVLFDPARCEEKVVTPEGKTWGIPTASDVRNTLRWSPACLRE
TLRKHSVVPLVMRRALKNDVWPASITGLDGDVTIPAGCSVAVGIQAVHRRPDIWPDPDAF
RPERFLDVKLENNFTTPNHEAYKDTVDPYAFIPFINGPRNCLGQHLSLMETEVALAYLFL
NWDLRFYGADAGATDVEKRLFQEEVGRPHVFMFPIVPQNGLKVVGTPRI*
CYP5122A1 Trypanosoma congolense
Sanger Center congo1115f09.q1k, congo1308e11.q1k,
congo940a06.q1k, congo1493e04.q1k
73% to T. brucei CYP5122A1
MLLFTGLLSEWGLQPQRALFSIDFLSYCKSSFLELYGLSCDKVSRLRSETFLLVCIT
ALAVLLVLYWLYNVVFPALAADRHLAHVPRPPGGLPVFGHAFALLEGYPSSKMAAWSLRP
GAASVAEGSGSPRANRIVTFNVFNQRVVYINEPALIKRVLLTNQRNYSKDIASSYKHF
MCLLGNGLVTAEGQKWRKGRIMLSHSLRIDILEDIPTMTMSAVERMMAKLRAVGTEAPFL
DLNEEFRHMTLQVIGQTVLSLRPDETDCIFPTLYLPIVHECNRRVW
EPWRTFMFFSEGFRNRRACLKQLDKVICDIIEKRWAERGVSGKGDVMSLCL
SQIDKLDKHMLLQLRDDVKTLLLAGHETSAALLTWATYEVLCHPEIKEKIVAEAKALFDP SHCSKT
LETPQGTWGIPSALDVKKKLRWTPAVL
RETLRRHSVVPLVMRVALNNDRWSAAETGLDEDIVIPAGCSVAVGIEAVHNRPDIWPDPDAFVPER
FLGVDIPNDTNSQPGDHFEKSVDPYAFIPFINGPRNCLGQHLSMMEAQVALAYLLLNWE
LRLYGTTAGSNGSRVAEQDVQREFGLSHRFLIPIVPANGLKVTGVPRSRS*
CYP5122A1 Trypanosoma vivax
Contig4157
70% to CYP5122A1 T. brucei from the MDR seq.
Some similarity to Chlamydomonas CYP745A1
MSSTDQFTLLVAHAIGDFFANSTNKSLLLSSVLTVALLALLWWVLFAFLPGLV
MDRHLMHVPQVRGRLPFFGHALLLL
EGSPTSKMAAWSLDPLRREGGKRENGEKINRLVTFNVFSQRVVYINEPALLKRVLLTNQR
NYIKDIPSSYKHFMCLLGSGLVTAEGDKWRKGRLMLSHSLRIDILEDIPEMAVKATGRIL
DKMPTTTGGPSFIDLNEEFRHMTLQVIGETVLSLTPEETDRIFPTLYLPIVHECNRLVWE
PWRSLLPFSEGARQRRSCLKKLNRVICNIIRERWKARSETGKRDVMSLCMSQIDSLTSGM
VAQLRDDVKTLLLAGHETSAALLTWATYEVICHPEVRDKIVEEARVLFDPVRCERTVVTP
YGTWGIPTASDVRALLRWTPATLRETLRKHSVVPLVMRLAKKNDTWPASETGLERDITIP
AGCSVAVGIEAVHHRPDIWPDSDMFRPERFLDVDTANSHASGRSVDGGRSIDPYAFLPFINGPRNCLGQH
LSMMETQVSLAFLFLNCDLRLCDVDATGGHRDALELQHEVGQPHAFLIPIVPRNGLKVHA
VPAAPRPCVQTTATV*
CYP5122A1 Leishmania donovani
GenEMBL DQ267494
Mehta,A. and Shaha,C.
59% to 5122A1 T. Brucei, 57% to T. cruzi,
55% to T. vivax, 56% to T. congolense
apparent ortholog of these Trypanosoma sequences
MVFDTDFLFVNRSQMAANALQSYIVAALHNAAAKLPSSVQPYAM
VLTREDMVSTTLATAIATAVILYTVIAVVLPVLRMDFYLSKLPTIKHGIPFLGHALLL
AGPSPWSKMSNWSLYPEKNLPQKKKGVDGSKTSRLVTFNVAGMRVIYINEPRLLRRVL
LTHQRNYRKALAAAYKHFMCLLGTGLVTSEDEQWKKGRLLLSHALRIDILDSVPEMAM
KAVDRILLKLDAVNAKNPSVDLNEEYRHMTLQVISESALSLSAEESDRIFPALYLPIV
HECNKRVWAPWRAYMPFLHGSRVRNHCLSELNKVLRDIICRRWEQRNDSKYTAKPDIL
ALCISQIDRIDEKMIVGLIDDVKTILLAGHETSAALLTFATYEVLRHPEIRQRVLEEA
TRLFDPARCTRTVQTRYGPRGVPSVNDVRDLVWTPAVLRETLRRHSVVPLVMRYAAKD
DVWPAEDTGLDADVRIPAGCTIAVGIEGVHNNPDVWNKPEVFDPTRFIDAEIANDTNY
LNRSTKDVKFAKKIHPYAFIPFINGPRNCLGQHLSMIETQVALSYMMLNYDLTIYRDP
SYKGDVAAYEDAVGRHHDFIIPQVPHDGLKVWGTPNKLFM
CYP5122A1 Leishmania donovani chagasi
GenEMBL CV661378.1 EST
95% to CYP5122A1 Leishmania donovani
PEMPMKAVDRILLKLDAVDAKNPSVDLNEEYRHMTLQVISESALSLSAEESDRIFPALYL
PIVHECNKRVWAPWRAYMPFLQGSRVRNHCLSELNKVLRNIICRRWEQRNDSNCTGKPDI
LALCISQIDRMDEKMIVGLIDDVKTILLAGHETSAALLTFATYEVLRHPEIRQKILEEAT
RLFDPARCTRTVQTRYGPRGVPAVNDVRDLVWTPAVLRETLRRHSVVP
CYP5122A1 Leishmania major strain Friedlin
GenEMBL CP000079.1, also XM_842870.1
chromosome 27
94% to CYP5122A1 Leishmania donovani
MVFDTDFFVVNCSQMAANVLQSYIVAALHSAATQLPSSVQPYAM
MLTREDMVSTTLATAIATAVILYTVITVVLPVLRMDFYLSKLPTIKNSIPFLGHALLL
AGPSPWSKMSNWSLYPEKNLPQKKKSVDGPQTSRLVTYNVAGMRVIYINEPRLLRRVL
LTHQRNYRKALAAAYKHFMCLLGTGLVTSEDEQWKKGRLLLSHAMRIDILDSVPEMAM
KAVDRILLKLDAVDAKNPSVDLNEEYRHMTLQVISESALSLSAEESDRIFPALYLPIV
HECNKRVWAPWRAYMPFLHGSRMRNRCLSELNKVLRDIICRRWEQRNDSNYTAKPDIL
ALCISQIDRIDEKMIVGLIDDVKTILLAGHETSAALLTFATYEVLRHPEIRQKILEEA
TRLFDPARCTCTVQTRYGPRGVPALNDVRSLVWTPAVLRETLRRHSVVPLVMRYAAKD
DVWPAADTGLDADVRIPAGCTIAVGIEGVHNNPDVWNKPEVFDPTRFIDAEIANDTNY
LNQSTKDVKFAKKIDPYAFIPFINGPRNCLGQHLSMIETQVALAYMVLSYDLTIYRDP
SYKGDVAAYEDAVGRHHDFIIPQVPHDGLKVWGTPNKLFM
CYP5123A1 Leishmania major
GenEMBL AQ850658.1 AQ849103.1 partial
Complete seq on LM34.1.Contig35 L. major Friedlin chromosome 34
CYP4-like, C-term is 37% to CYP4C25 of Anopheles
145491 MTPTVSPVQAAAAIATVGFLAYATTRMLQALYSAPPNIPEPAIP
PNSEDGLVWSVIKRVLYRHFYVVRKGDPLKTLQRWCVEFDYKPFVMKIFFRPHVVLSSPV
DIEHVLLRADTKFYKDTGYDIVRIVVGRVGLLAVGNKAQHAVHRRILMPIFRSQNIRGVA
NEIIRMHALRMMGGLFHLIQCGGEQDAVVNLSDHVFRMALSAIGEAAFRASRSESLRVRG
HFDVMMKMSRVNYFC
146208 PYLKSSAQRNARNTLKEMSVELLDKNMQINQIGTRRCVMDALIDELYVHFSMDDV 146372
146373 LDHVVTFLFAGHDTVSHTLEFLFALLGTNTEVQERLYEALEDLMPSICTCPTVQELME 146546
146547 CDYLVAIVKEVLRMYPAAPIIYRDAAEDVYLPGSAVVIPKGMTVVITLSALQRNTHVYGD 146726
146727 DVDVFRPERWLGEEGEALRKRCGRCGYIPFSCGKRSCIGQELGYLELLVVTALMGRHLK 146903
146904 MELVGKFPEARYNITIAVSHSVSMRITARDGIPVSEVYERIANVLDLNDEDAGSARNVTRGV* 147092
CYP5123A1 Leishmania infantum
Contig2424 Leishmania infantum
97% to L. major, 13 aa diffs, ortholog
1504 MAPTVSPVQAAAAIATVGYLAYATTRMLQALYSAPPNMPEPAIPPNSEDGLVWSVVKRVL 1325
1324 YRHFYVVRKGDPLKTLQRWCAEFDYKPFVMKIFFRPHVVLSSPVDIEHVLLRADTKFYKD 1145
1144 TGYDIVRIVVGRVGLLAVGNKAQHAIHRRILMPIFRSQNIRGVANEIIRMHALRMMGGLF 965
964 DLIQCGGEQDAVVNLSDHVFRMALSAIGEAAFRASRGESLRVRGHFDVMMRMSRVNYFCP 785
784 YLKSSAQRNARNTLKEMCVELLDKNMQINQIGTRRCVMDALIDELYVHFSMDDVLDHVVT 605
604 FLFAGHDTVSHTLEFLFALLGTNTEVQERLYEALEDLMPSICTCPTVQELMECDYLVAIV 425
424 KEVLRMYPAAPIIYRDAAEDVYLPGPAVVIPKGMTVVITLSALQRNTHVYGDDVDVFRPE 245
244 RWLGEEGEALRKRCGRCGYIPFSCGKRSCIGQELGYLELLVVTALLGRHLKMELVGEFPE 65
64 ARYNITIAVSHSVSMRITARD 2 (missing 32 aa)
CYP5123A1 Leishmania braziliensis
GenEMBL BX538392 BX543712 BX544215 BX543549
86% to L. major CYP5123A1
MIPITLPVKATAVVATVGALTYATMRALQAVYSAPPNMPEPAIPPNPEDGPLWSVVKRIL
YRHFYVVRKGDPLKTLQRWCTEFEYKPFVMKIFFRPHVVLSCPGDIEHVLLRADTKFYKD
TGYDIVRIVVGRVGLVA
(65 aa gap)
ALSAIGEAAFRASRSESLRVRTHFNAMMKMSRMNYFCPYLKSAAQRNARKILREMSVGLL
DKNMQMNQIGARRCVMDALIDELYVHFSMEDVLDHVVNFLFAGHDTASHTMEFLFALLGA
NKEVQDRLYEALEDLMPSICTCPTVEELMECDYLVAVVKEVLRMYPAAPIIIRDAAEDVYLPESRVVIP
KGMTVVITLFSLQRNTHVYGDDVDVFRPERWLYEEGEALRKRCGRCGYIPFSCGKRSCIGQEFGYL
HPLIVTALLVRHLKMELVGKFPEARYNITLVMSHPVSMRITAR
DGISVSQIPGRIAN (19 aa missing at end)
CYP5123A1 Leishmania donovani
GenEMBL EF405866
93% identical to CYP5123A1 of L. major
MTPTASPVKAAAAIATVGLLTYATTRMMQAVYSAPPKMPEPAIP
PNSEDGLVWSVIKRVLYRHFYVVRKGDPLKTLQRWCAEFDYKPFVMKIFLRTHVVLSS
PVDIEHVLLRADTKFYKNTGYDIVCIVVGRVGLLAVGNKTQHAMHRRILMPIFRSQNI
RGVANEIVRMHALRMMGGLFDLIQCGGEQDAVVNLSDHVFRMALSAIGEAAFRASRSE
SLRVRSHFDVMMKMSRLNYFCPYLKSSAQRNARKILKEMSVELLDKNMQINQIGTRQC
VMDALIDELYAHFSMDDVLDHVVTFLFAGHDTVSHTLEFLFALLGTNTEVQERLYEAL
EDLMPSICTCPTVQELMECDYLVAVVKEVLRMYPAAPIIYRDAAEDVYLPGSGVVIPK
GMTVVIALSALQRNTHVYGDDVDVFRPERWLGEEGEALRKRCGRCGYIPFSCGKRSCI
GQEFGYLELLVVTALLVRHLKMELVGKFPEARYNITIAVSHSVSMRISARDGIPVSEV
YERIANVLDLNDEDAESPRNMTQAAGGERRCREGAVRR
CYP5124A1 Toxoplasma gondii Alveolata; Apicomplexa
GenEMBL CB302460 CD216983 CN122383.1 CF268313.1 (ESTs)
AAQM01000094.1 (genomic, in GSS section)
Cannot identify N-terminal from the genomic sequence
Whole seq now known from mRNA, but confidential
SSGHLALT (?)
PKRDETGVLPYSTVDAMMTTSRFHKENYELLFLPTDSSGAACTASHRALVRQYKSVVNA ()
TPVILTQMLDETNQYALLPIIL ()
AAEDSVTRRGLMADEIRDTASLLLLAAENTALPIVWALYELAKDPL ()
LQERIYTATRMEDLTLVDSTDHLVSHLGEVLNVFLESLRFYALPILSRSASKAIHL ()
KSVDFSIPAGTVILVDNYSLTRDEVLWGQDANVFNPDRFVGRIWQQAPWL
PFGFGTRKCLGERLAVAHAVIFLAFIVRHFALDLDVNSMPPE()
PMERQFLTPDKPVMLRFKPRA*
CYP5124A2 Neospora caninum Liverpool (alveolate)
FR823392.1
complete genome, chromosome XI Length=6081843
Eukaryota; Alveolata; Apicomplexa; Coccidia; Eucoccidiorida;
Eimeriorina; Sarcocystidae; Neospora
79% to CYP5124A1 Toxoplasma gondii
4604488 MSELTAGSDMFSAIPAGVQQVIRNVVFWGATDETAQKWR (2) 4604372
4603939 LRVLGVGAVAVAGAASWVYLIYPFLQHMKVRNLPQPGTSTWLNGDKKELEK (2) 4603787
4603451 HVKGGEKRRYFSRLRQTVGPNCFIRLPLQFSLASLTKNPFGLLFVTSDWNVIQELTTQSGSL (0) 4603266
4602869 VRNPEWVQAFEVISDSVIATDSEQTARFHRRILSTFTTHTAANGTMKPLMDLLDLLRR (0) 4602696
4602215 DLVALNDTRAVDALQLTRLAMFDLWLNLLTGRQGHHALTASGHLALT (0)
4601788 PNRIETGALPYSTVEAIMTMTRFHKENYELLFLPTDSSAVTSTAAHKALVQQYKAVVNA (2) 4601612
4601444 APVILTQMLDEKNQQALLPRIL (0) 4601379
4600792 AAEDSVTRRGLAADEIRDSAALLFLASENTALPIVWALYELAKDQA (0) 4600661
4600427 LQQRIHTATRVEDLTVIDSTDQLISRLGEVLNLFLEALRFYALPILSRSASSPIQL (0) 4600260
4599739 KSADLTIPAGTVVLVDNYSLTRDETLWGQDANVFNPDRFSGKIWQQAPWLPFGFGSRKCI 4599560
4599559 GERVAVTHAVLFLAVVVRYFALELDTNSMPPE 4599464 (2)
4599006 PVERQFLTPDKPVMLRFRPRV* 4598941
CYP5125A1 Aspergillus nidulans
Genome gene number AN8437.3, 34% to XP_755777.1 Aspergillus fumigatus
34% to Chaetomium globosum XM_001227760,
34% to NW_001509762.1 Neosartorya fischeri
MEITAYFCGALLLLLWYRVCARQSVDKTQVQLRQNIIL (0)
VKNTPYAIPTPEAYQVHFSSATHIKQLIQAPDTHLSLHALAKD (0)
MFQPTHTMDGLAVDDCMSANGT
IHQRALQAELRSHLPALTQPLSECIARTLTKEVSQASGSLAAVGDGWRALQLFPLAKRLVVSANALTFFGPEVSSNPIFL
NAALEYPEHMMQTAEILRLLPS (2)
ALTVLLDTLIPIIERRLYEHQSRPEQAEARVPRDCIQFFVNAV
KHKKQLDKWHAQRIVQVLLGIWFASVHQPAMCLFYALDDLCLHPEYVVPLREKISQAVQ (0)
IDISTLPLLDAFLKESARLHPTDSISVRRKALRPFTFSDGTSLAKGDVACIPLQPALQNPESYANPLTFNPHR (2)
FLKDKMTSTYIRSSRSRFTDADVAFPIWGLGKHACPGRHYASLLLKLVLAHVLLRYEIKLPDRNRRSEKRS
FYWRSAIVPRSGAVLYFRERGSCTE*
CYP5126A1X Aspergillus fumigatus Af293
GenEMBL XP_755777.1
Same as CYP5091A1, use earlier name
1908580 MLEILVTFLIFCFRRIRGLWYLARGPEIIDRAYIA 1908684
AEGKPFRIYTPSNDHLLVTSKEHIAELVNAPLQNLSLHAVAKE (0)
ILQPKYTMFGFEWHNQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGSPQLCLIPSDCS
RLRALQTVPYDQANGHQGQLLRLLRGGTWYDYPWHVRHRQAHCVAAQNPEFTAAALEFPQRVILAAEILR
ITPSFLR (2)
RTLFRYLKPIVEKRLAARANSPRSLQEDAP (0)
MDCMQWLIDTSPRKIPWTPTRMVGEIVAVWFGS
VHQLAM (0) 1909749
1909815 TTTYAIEDLCLHSDYVEPLRAEIQQYLEGPCRRRVAEMPLLDSFVRESIRCTNSDA (1) 1909961
1910033 LTVRRKALTPFMFSDGLEVAEGDWVCIPQRAMMRDRIRYQNPQAFDGFRFARANK
QLRAGDVSLDVPENSPLTMTDVSVDWPIWGLGKTAC (2)
PGRFYAATILKLIMVCILEKWECRLENPKSQRWR
TWRSSVVPREGTVVMFRRKEEALTG
CYP5126A1X Neosartorya fischeri NRRL 181
GenEMBL NW_001509762.1
ortholog, 92% to A. fumigatus XP_755777 revised
Same as CYP5091A1, use earlier name
MLEILVTFLIFCFRRIRGLWYLARGPEIIDKAYIA (0)
AEGKPFKISTPSNDHLLVTSNEHIAELVNAPLQNLSLHAVAKE (0)
ILQPKYTMFGFEWQDQRGVEGTGFVRALRSRLTAHLPILMPELQRIVETAIADELVAPGSDGKWGPP 530
531 QSCLIPSDCSRIRALQIVLYDQANGHQGQQLCLLRGGTWYDYPWHVRHRQAYCVAAQNPE 710
711 FTAAALEFPQRVILAAEILRITPGFLR 794
5164664 RTLFRYLEPVVEKRLATRANSTRSMQEDAP (0)
MDCMQWLIDTSPRK 5164843
5164844 IQWTTTRMVGEIIAVWFGSVHQLAM (0)
TTTYAIEDLCLHSDYVEPLRAEVQQYLAGSCRRRVAEMPLLDSFVRESIRCTNSDA (1)
ITVRRKALTPFVFSNGLEVAEGNWVCIPQRAMMRDRIRYRNPQAFDGFRFARANK QLRA 5165393
1626 GDVSLDVPENSPLTMTDVSVDWPIWGLGNTAS (2)
PG 1806 RFYAATILKLIMVCILEKWECRLEDPKSQRWRTWRSSIVPREGTVVLFKRKEEALTG 1976
CYP5127A1 Chaetomium globosum CBS 148.51 (CHGG_09834)
GenEMBL XM_001227760 (my version is a revised sequence)
34% to CYP5125A1 A. nidulans,
36% to XP_755777.1 Aspergillus fumigatus
36% to NW_001509762.1 Neosartorya fischeri
MNTMNNTIAVKALGLQQTWPPASLLRVNPLAAVVVAGMLALLCLQACTSGNKLL (0)
ANGEPYEVLAPDGRYVFVSSPKYIKEMDSAPDTVLSLQAAAKQ
MLQPIHTMHAFNWFDRRGTEGVGFVKALRTMLTNNLPAVLPDLSTIIRT
RFESLHEAHPKINGVTQSPVYVMNVKLVVLSNAVSFFGKDL (1)
AKNEAFMESALTYIEETFVCAEIVRLLPKFMSP (2)
ILGRLMRRRLKSQDVVYNTLLAVTEQRCLERDMKNLGQDVPYH
ADCIQWIMETSPRAKPWTPMRIVHELMAIWFGSVHAVHT (0)
TITFAIHDLCLHPEYVEPMRQELLAGYADFEKTGLGLPLMDSFIKESARITPVEA (1)
QSTRRAALRPFTFSDGTKLNVGDWGC
TPVKAMMHDAEFYPEPLQFNGFRFADPAIVQAAGDHFKTPQPKPSKLTDCSSTYHVWG
TGRMACPGRYYATAVMKVILGQIIMNYHCELLNREESRCVTWRSTMLPKHSTKVVFTRRAD
CYP5128A1 Aspergillus nidulans
Genome gene AN1703.3
Changed from AN1703.2; change type is EVIDENCE_CHANGED
Too short at C-term, N-term is wrong, revised
66% to Aspergillus terreus CYP5128A2
50% to AAID01000197.1 Botryotinia fuckeliana B05.10 cont1.197 CYP5128B2
46% to AAGI01000270.1 Phaeosphaeria nodorum SN15 cont1.270 CYP5128B1
43% to AAGT01000426.1 Sclerotinia sclerotiorum CYP5128B3P
40% to AAIL01000498.1 Trichoderma reesei CYP5128C1
MSLIVLFIVILLSLIIRALYLLYR
HPLSSVPGPKLAACTSLWLAYHTYIGDECSTLFALHQRYGPVLRIAPNDVDI
ASGDAIEPIYLARGGFPKTPVYSKFDIDGHSTIFSTLTLPERASRAKAVAPLFSTASIRNSQERLLEVVDDFVDRLRQGA
QSGRPVNVLGLARAMAIDAVSAYLFQERYGALDENAEVMSASLFVDAYVGVGAFFNFVCGRVGEFLVGLVEYLTQLSGTA
KSFTAIDDYTSRLVRQAVPKSGSYQIRLLERVSLRQTQIEIKDVCFAGTDSTGMDVATIIWYLAKYPEKYIKLRTALENN
PPDGDPLSTPYLRAVIREGLRLSWANPTRLPRSVPAGGWKYKSYSFPEGTSVGISAWQLHQEESIFPNPLSFDPERWLEP
NVTDDMLNNFFAFGKGTRACIAQNLGTAEVTLAIWKVVEKDMLRGAR (0)
ILQWFNSRVKGEEILVQWIDR*
CYP5128A2 Aspergillus terreus
GenEMBL XP_001210824.1, EAU39384.1
66% to AN1703.3 CYP5128A1
49% to AAGI01000270.1 Phaeosphaeria nodorum CYP5128B1
47% to AAID01000197.1 Botryotinia fuckeliana CYP5128B2
42% to AAGT01000426.1 Sclerotinia sclerotiorum CYP5128B3P
40% to AAIL01000498.1 Trichoderma reesei CYP5128C1
49% to AAIM02000125.1 Gibberella moniliformis partial seq CYP5128C3P
VDKEIQ may be an intron
1 MYKSLLERGP VVLGGFLLVL IAFCVCKSIY RVYF HPLSHV PGPKLAAATS LWLAYHTFIG
61 DECTTVSELH KRYGPVLRVA PNDIDIADGE AIEPIYLAHG GFPKTRAYSK FDIDGHTTIF
121 SSLTLSERAT RAKAVAPLFS TASIRQSEQA LGVVFDDFVA RTRREAQTGR PVNVLNATRC
181 MAIDAVSMYL FQKRYGAIDE GSKTMSASPF VDAYVGVGAF FNLAHGKISD ALMRFIDRWN
241 TTQATETAFQ LMDAYTSQLV KTAVPKSGSY QSRLLEREIS EELSQIELKD VCFAGTDSTG
301 MNMATIMWNL AKHPDVYARL RQELQDSAAR DEDLTSCAYL RGVVREALRL SWANPTRLPR
361 AVPSGGWRFK DYFFPAGTSV GVAGFQLHQD EEVFPEAQRF RPERWLQPTD AMLNNFFAFG
421 KGTRACIAQN LGTAELVWAT IKVVQADLLR GARI
VDKEIQ
ILEWFNSRVK GEKILIQFDVQS
CYP5128A3 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_70180|Aspni1
69% to CYP5128A2
see fungal pages for seq.
CYP5128B1 Phaeosphaeria nodorum SN15 cont1.270
GenEMBL AAGI01000270.1 (WGS section)
67% to AAID01000197.1 Botryotinia fuckeliana CYP5128B2
60% to AAGT01000426.1 Sclerotinia sclerotiorum CYP5128B3P
47% to AN1703.3 CYP5128A1
49% to A. terreus CYP5128A2
44% to AAIL01000498.1 Trichoderma reesei CYP5128C1
52% to AAIM02000125.1 Gibberella moniliformis partial seq CYP5128C3P
30% to 532C2
VEIYE = intron?
MLTILLTPLALLLVRSLYRIFAHPLSHIQGP
LLPKITSLWLHYHAYIGDEASVIHELHAYYGPLVRVSPNEVDISDADAIQPIYVSKGGFP
KADCYANFDIDGHKTIFSTTDHDHRAARAKAVMPLFSTKALRENESAIWACVDRMIERLK
SESKSKRPVNVLNLTRSLAVDAVSTHLFRENYDGVSEQGPTLSVSAFVDAFVAVGRFFYL
PNVLFVWLEWAITKWQADRETDDSMTLVDKFVSNLVANTTPKSLTYPGRLLAVGISDSEV
KAQCKDLVFAGTDSTGMNLATIMRSLAVYPDKYERLKKEVDENIARGSDAQEVQALPYLN
AVVKEALRISMANPTRLPHVVPAGGWTFKEFCFPATSIVGCSGYELHFNAKIFPDPTAFV
PERWLEPTEEMSKYWFAFGAGSRACIARNLATLELQFATERLARSGVLDGAKAVQDK
VEIYE
WFNSKVKGEKIELMWG*
CYP5128B2 Botryotinia fuckeliana B05.10 cont1.197
GenEMBL AAID01000197.1 (WGS section)
75% to AAGT01000426.1 Sclerotinia sclerotiorum
67% to P. nodorum AAGI01000270,
47% to A. terreus,
50% to AN1703
42% to AAIL01000498.1 Trichoderma reesei
50% to AAIM02000125.1 Gibberella moniliformis partial seq
MALLEQVSGLLTTNPLIVLVTITTLSLLFRSTYRCTLHPLSHIPGPLLPKL
TSLWLHYHAYIGDEASCIHRLHNQYGPIVRVSPSEIDIADADAIAPIYISKGGFPKAPCY
ANFDVDGHKTIFSTTDAEFRAPRAKAVMPLFSTKSIRDNEVALYGCVENMVGRMKEDAEG
GAPVNCLNLARSLALDAISTHLFSENYNGTSEKGERLSASAFVDAFVAVGRFFYLPNAVF
IWLSWFVEKLVMDSHTENSIKLVDQFVENLVESTPKESNNYPGRLLNTGFSKSEVKSSCK
DLMFAGTDSTGMNMATILRYLVLCPEK (2)
YEILRTEIMGNANSTTKQEIQALPYLSAVVKEGLRISMANPTRLPHVVPIGGWTFKSVY
FPAGSIVGCSAYELHFNQDVFPNPHEFEPERWLEG
13108 NITPEANKYWFAFGAGSRACIARNLATVELYMAVEKVVESDVLRGAR (0)
IFEWFNSSVKGEKLELIWNRNEKR* 13345
CYP5128B3P Sclerotinia sclerotiorum 1980 cont1.426 pseudogene
GenEMBL AAGT01000426.1 (WGS section)
75% to AAID01000197.1 Botryotinia fuckeliana
60% to P. nodorum AAGI01000270
47% to Gibberella moniliformis
43% to AN1703
42% to A. terreus
1680 LLENPRSQKTTDPLTILLTTLTLFLLL
1598 STYHCTLL
1573 PLPHIPGTFLPKLTSL*LHYHAYTGNEASTIHKLHAQHDAIIRVSLSEIDIADADAITPI 1394
1393 YITKGRFPKAPCYANFNVDRYKTIFSTTDVEFRAARAKAVMSLFSTKCINLRDNEIALYR 1214
1213 CVNNMVRRMREEAKE*KQLNCLNLTWSLA
1127 LDAISVHLFLENYNGTLEKGERLSASAFVGAFFAVGRLF 1011
FYLPSTVFVWLSWFMEKLVMDSHTQNSIKLADQPVDNLVES
888 TPKQSQNYPRRLLNIKSEVKAHCKDLIFAGTDSTNMNLATIFRQLFLCLEK 736
YEILCA*IMENVNS 632
621 K*EIQTLPYLDLSAVVKEDLCISMANPTRLPHVVPTGGWTFKSVYFPARTIIGCSAYELH 442
441 FNAEVFPNPYEFQSERWLEGNV 376
6194 TAEANEYWFAFGAGSRACIARNLAMVELLTAIEKVVENDVLRGAR (0)
IFEWFNSSFKGEKMELICS* 5979
CYP5128C1 Trichoderma reesei QM9414 Treesei_Cont498
GenEMBL AAIL01000498.1 (WGS section)
63% to AAIM02000125.1 Gibberella moniliformis partial seq
48% to AAJI01000647.1 Ajellomyces capsulatus partial seq
44% to AAGI01000270.1 Phaeosphaeria nodorum
42% to AAID01000197.1 Botryotinia fuckeliana
40% to Aspergillus terreus
MAAHATVTANLLASLSPLTIGLSVVSILLLKAAHGLTTDRLRHIPGPLIARLTPIWYWYIV
WRGIECRAIAVLHKKYGPVVRIAPNEIDISDGAAVAPIYIDNGGFLKHPAYRNFDINGFP
TIFSVTDHAHRAVRAKAVAPLFAQQAINNSKPAMRRIIDTTLSGLERRKSLANGKPVDLL
DLFRCMAMDVMTEYLVGECFHSVGSKRLSVAGFVDGFVAAGRFFYLPTRLFTLFEYCASR
LNKSQALITASIDTVQSFATKVVDDSIARGEKATYQGRLLKAGISREEAIAQVIDIMFAG
TDGMARVLAVFCWHMARAPEK (2)
YDRARKEILQYPDTDARSLPYLSGAVKEAARLALANPTRLARIVPSGGLKVPGLP
SIPAGTSVGIGAYALHLNPDVFPTPYDFLPERWLEC
22767 TPEMLRDSFYFGKGSRQCIARNFASAIVWWGAEALVRNRVLDGAKP
IVEWFNSKQVGENIELTWQ* 22552
CYP5128C2 Histoplasma capsulatum Nam1 teleomorph: Ajellomyces capsulatus
Supercontig 1: 6516655-6517422 (+), cont1.647
GenEMBL AAJI01000647.1 (WGS section)
48% to AAIL01000498.1 Trichoderma reesei, runs off the end
39% to AAGI01000270.1| Phaeosphaeria nodorum
40% to AAID01000197.1 Botryotinia fuckeliana
41% to AN1703.3
38% to Aspergillus terreus
3 aa diffs to CYP5128C4, 5128C5, 5128C6
5 aa diffs to CYP5128C2
MATGIVATAHNAFPSPPSIPI
14069 STTVVVVVVVVPVVLLLVKLHTDSLRYIPGPLIARLTPLWLWTLTHRGIECRLAAL 14236
14237 HSRYGPAVRIAPNEVDLSDAAALYPLCAKNGGCAKNPVYANYDIDGFATIFSAVDPVQRA 14416
14417 AKAAAVAPLFAQRAIVEGRELGARRAVAHGAPIDVLDLFRYLAIDVVS 14560
14561 LYLFGESFGGLGSKAPLAAMPFVDAFAAGGRFFYVPGWLFRHVDHWAGKFEKGARSIAAS 14740
14741 TAVVKEFAARV 14773
CYP5128C2 Histoplasma capsulatum G186AR teleomorph: Ajellomyces capsulatus
Supercontig 4: 1885071- 1886719 +
MATGILATALHAFPSPLSIPISATVVVVVVVPAVLLLVKLHT
DPLRHIPGPLIARLTPLWLWTLTHRGIECRTLAALHSRHGPAVRIAPNEVDLSDGAALYP
LYAKNGGCAKNPVYANYDIDGFATIFSAVDAVQRATRARAVAPLFAQRAIVEGRPTMQAV
VDAAVAELGARRAVAHGAPIDVLDLFRCLAIDVVSLYLFGESFGGLGSKAPLAATPFVDA
FAAGGRFFYVPGWLLRHVDHWAGKFEKGPGSIAASTAVVKEFAARVVDRSIAGEKAGVAQ
TSTYQGRLLRAGISREETIAQVLDVMFAGTDGIAMTMSVLCWNLARLPD (2)
RYTRARHELLNNPSPLNGQSLPYLTAI
VKESLRLSMANPTRLPRIVGAEGLHVPGLPTLPAGTSVGLGAYVLHHDPAVFPQPREFMP
ERWLACTPEMLRNSVPFGVGARMCIARNLAVAVLRWT
AEALIRADVLGKNNNIHDGGVGD
GVRGVVQDGIEIMEWFNAKVVAGKIEIY*
CYP5128C2 Histoplasma capsulatum H143 teleomorph: Ajellomyces capsulatus
Supercontig 4: 1916858-1918502 +
MATGILATALHAFPSPLYIPISATVVVVVVPAVLLLLKLHTDPL
RHIPGPLIARLTPLWLWTLTHRGIECRTLAALHSRHGPAVRIAPNEVDLSDGAALYPLYA
KNGGCAKNPVYANYDIDGFATIFSAVDPMQRAARARAVVPLFAQRAIVEGRPTMQAVVDA
AVAELGARRAVAHGAPIDVLDLFRCLAIDVVSLYLFGESFGGLGSKAPLAATPFVDAFAA
GGRFFYVPGWLLRHVDHWAGKFEKGAGSIAASTAVVKEFAARVVDRSISGEKAGVAQTST
YQGRLLRAGISREETIAQVLDVIFAGTDGIAMTMSVLCWNLARLPDR (2)
YARARHELLNNPSPLNGQSLPYLTAIVKESLRLSMANPTRLPR
IVGAEGLHVPGLPTLPAGTSVGLGAYVLHHDPAVFPQPREFMPERWLACTPEMLRNSIPF
GVGARMCIARNLAVAVLQWTAEALIRADVLGKNNNIHDGGVGDGVRGVVQDGIEIMEWFN
AKVVAGKIEIY*
CYP5128C2 Histoplasma capsulatum H88 teleomorph: Ajellomyces capsulatus
Supercontig 2: 3175396- 3177043 +
MATGILATALHAFPSPLYIPISATVVVVVVVPAVLLLLKLHTDP
LRHIPGPLIARLTPLWLWTLTHRGIECRTLAALHSRHGPAVRIAPNEVDLSDGAALYPLY
AKNGGCAKNPVYANYDIDGFATIFSAVDPMQRAARARAVVPLFAQRAIVEGRPTMQAVVD
AAVAELGARRAVAHGAPIDVLDLFRCLAIDVVSLYLFGESFGGLGSKAPLAATPFVDAFA
AGGRFFYVPGWLLRHVDHWAGKFEKGAGSIAASTAVVKEFAARVVDRSISGEKAGVAQTS
TYQGRLLRAGISREETIAQVLDVIFAGTDGIAMTMSVLCWNLARLPR (2)
YARARHELLNNPSPLNGQSLPYLTAIVKESLRLSMANPTRLPR
IVGAEGLHVPGLPTLPAGASVGLGAYVLHHDPAVFPQPREFMPERWLACTPEMLRNSIPF
GVGARMCIARNLAVAVLQWTAEALIRADVLGKNNNIHDGGVGDGVRGVVQDGIEIMEWFN
AKVVAGKIEIY
CYP5128C3P Gibberella moniliformis 7600 chromosome 9 cont3.125
GenEMBL AAIM02000125.1 (WGS section)
probable pseudogene,
63% to AAIL01000498.1 Trichoderma reesei
49% to Aspergillus terreus
50% to AAID01000197.1 Botryotinia fuckeliana
52% to AAGI01000270.1| Phaeosphaeria nodorum
44% to AN1703.3
47% to Sclerotinia sclerotiorum
43% to AAGI01000142.1 Phaeosphaeria nodorum
VKSPLCWNLAQLPKK
YDRIYKEVIENTELDAQSLPYLTRVV
KESLRLSMANPNRFPRIVPPGGMQVPV
LPNIPAGTSVGAGAFMLHHNPEVFPEPHQFMPERWL
463566 NPSQEMLRDSFYFGDGSRQCIARNLVSAGLWWAAEALIRSDVLRGAKV (0)
IVEWFNAKIVGEKI 463769
ELRCE
CYP5128D1 Mycosphaerella graminicola
JGI gene model e_gw1.7.775.1|Mycgr3
43% to CYP5128B1 Phaeosphaeria nodorum
44% to CYP5128B2 Botryotinia fuckeliana
see fungal pages for seq.
CYP5128E1 Grosmannia clavigera
CYP5129A1 Phaeosphaeria nodorum SN15 cont1.142
GenEMBL AAGI01000142.1 (WGS section) 53447-54947 (+) strand
no small intron, frameshift after LLAA
37% to AAGI01000270.1 Phaeosphaeria nodorum
34% to Trichoderma reesei
34% to AAID01000197.1 Botryotinia fuckeliana
53447 MAFGTLLTLVACALFFRSLARIFVHPLRHVPGPIFA
STSSLFLYTICYLGVEGRVIRSLHHRYRSDVLRVGPNSVSIADSSALHDIYVSGGGFPKD
SRYSNFNLGPIVSIFSSTDTIYRDRRAKAVASLFAPNRLRSACEHDQVIGISVSRFIHLI
QEHKKERISFDLVDICARLSIDVVTEYLLGEPYGGFREIDHLSPRDQQYHKLSANPFIFA
IVAFSRFSLLPKWLFTRVYSLSTRLASDDEVKQSFRKLDSFISGVMSRLEDRPDHKADQT
YQSRLLAA
GIDPSEVAAQCKAVTFAGADSTA
VILTTIIFHLIVNPSICRILIAQLEAHQKASTGPLDPETVPYLRAVVKEGLRLGMANPTR
LTRVVPPSTALNVEGYAIPAGTVVGCAAYTLHHDPNVFPEPFEFKPERWIENRYDRNPLRLKMEM
54744 NMMPFGVGLRGCIGKNLAMRQLYETISAVCSTDTGLLEGARIKQQHIEVIEWFNGEIKGHRLDVHWE* 54947
CYP5129B1 Talaromyces stipitatus ATCC 10500
XP_002339964
44% to CYP5129A1
1 MALLQNLLTT VSKMSSWTLL LSIIGLFPVC LALYRLFLHP LSHIPGPWFA CISSAFLHII
61 CYQGTESRVF AHYHRKYKSP VLRIAPNSVS VSDGAALHTI YVAGGGLPKD SRYRNFRIEG
121 HETIFSSINP AFRDLRAKAV LPLFAPSRIR TSGENNGAIQ QSVEKFVALL EKEKQEACQG
181 RGNHHRVDIL DLTSKLSIDI LTGYLFDKVY GGLNEHDNNN KMNIGSSVPK HKRLSATPFV
241 LAIVAFSRFS LLPNWIFTIV FSIWFRVAMR ETDLVVSLGK VESFMNELMA ETETQLGRPG
301 VSMEETRSQC KGVMFAGADS TALVQSTILF HLIQQPAVLT RLKAEVEGTT PSTELQSLPY
361 LRAVFREGLR LALTNPTRMT RIVTTPDAKG INVSGFHLPP GTIVGAAPYI FHLNEEVFPD
421 PLKFQPERWL EEKRDGPGES QLRALRDRDT FPFGLGGRIC LGRNLATYQV LSTTKAIVQS
481 GVLEGARTCQ ERIEMIGWFN AEIKEHHLEI EWNS
CYP5130A1P Aspergillus terreus
CH476602
This P450 is six genes away from MSAS polyketide synthase
6-methyl-salicylic acid synthase used in patulin synthesis
patulin is a mycotoxin sometimes found in apple juice.
32% to CYP65S1
see fungal pages for seq.
CYP5131A1 Alternaria alternata
AB179766
AF-toxin biosynthesis gene cluster (Aft9-1,
Aft10-1, Aft11-1, Aft12-1, AftR-2, Aft3-2), complete cds.
31% to CYP548A2
This P450 is 2 genes from a PKS gene that is
47% identical to a PKS on chr 3 of Nectria haematococca
That PKS has no annoated P450s near it
MTYEKPDLKRTKATVSFKRIYLHRASEFPGPWLCQCSSIMAQYH
AWRGDLPRYLHVLHEKYGDFVRYAPNHVSIRHCDVWEDVYGFQRNVSKYDTTYSPFRL
APDFTSTWNTSNVDVHKSRRKLLNKLFSEQHLDDYGTLITVQVDEFMRQILEALPKDK
DVMAGPINFAYKSDVVAREIITSLVSGQTYGFQSGDAKSASLLADISKFERKLYLLGF
APWLKMLPSFKPTLALAQWIVQSSKQGLASGSKNTLVAKMLAARDEEKDVEFSRNDVI
ADARFFLLGGSVTSSSALSATLFFLLHHPVEMQELYDELRGIFPTYEDIKADAQLMRC
KRLRAVFEESMRLAPPVPTLLPRLVGPGGIKACGRYVPEGVVIGAPCWAISRDKRYFD
KPNVFKPDRWLADSSDPVALEKMLLATRASQPFSYGPRACPGRALAFRENGLLLAKLV
YAFEMEPVQDKSIVEESLTGICDGLVFNQLDTVGAHEVELMVRYRLRLDGKTKRRVSG
N
CYP5132A1 Botrytis cinerea = Botryotinia fuckeliana
AL115607.1 CNS01CJJ also = AAID01001229.1
30% to 670A1 36% to AACD01000002 Aspergillus nidulans new family
8628 MALIPGHYLIAAAVSGIAAHLCAFIHGDWHLHIPQVIFTHCAGYALLLLRLRYQELSIIDSIQASTVLSA 8419
8418 CYLLFLFTSIIVYRVFFHRLRNFPGPRLAAATKLWSIWETRDSRNHLLMQRLFEQYGPIVRT (1) 8233
8167 APNELTVFHPEGVELVKGGKNGTDQYNEKGVWYDLIHPKTSVVFNRNPSENAVRRRP 7997
7996 WDRAVSPAS (1) 7970
7916 SLRSYAANIVAPAAEVLEFVSNAQGEPVNINELMTGLIFDFMSVIVFGEVSSKTDAEEQIS 7734
7733 TLRRLKGALILLAPCGDSVWPALFAFNFLQFLKPVKSRLGLVESCRARMLKRMN (0) 7572
7512 KKTSTVDVSGFFLKDFHDSAGETSLEKRENA 7421
7420 LLGNTISALVAGSDTARAAMIGIFYFLCKNPGNADEIYEELKDVDEKDSTVLA 7262
7261 GKPILNGFIKEALRVAPPSMTGLARIIGPQGLWIDNTFIPPGAQVTAPYYNSHR (1)
LPSAFQDPTEFIAERWTSRPDLIKDKRAYAPWGA (1)
6886 GQHICPGKALANVELRYVTALFVKTFKIKFAPGHDPEKFWTDMLDQVTMQPGEV 6725
6724 WCVFEPRN* 6698
CYP5133A1 Fusarium oxysporum
AAHX01000914 32% to 639A1 new family
MAFLLLPILLLLLGTIYTRLQSRPHSHNDDSTKSPPQPSWGLQGLGHLLSLTLQPESFLTRLTY (0?)
23671 IYLAMPGKQIEGLFRRSSSLVPTPSLFDALTIFFGLSGRDIHIFNHDR 23528
23527 ISAYEASVGFYTDHPDVSRRIMEHQRQDFAHYLQGRNLVFVMERFKKNLASELSAASEIG 23348
23347 HDWGRIPDLFSFLSNLILRANVEALYGEHLLRICPTFCQDFWNFYKAFPNISKGLPRWL 23171
23170 VPSSYQARDEMHKNFDRWRTWCSENYNWDNDGLRDIEYEPIWGTQYVRKMIQRHEALGLS 22991
22990 NNGVAVVMLGYFF
22847 YSAMANTVPAALWMIVHILLDASLLRRVRHQISFAFQSTEVGEQPDIKVLMKDPLLNSIY 22668
22667 YETLRLRVASTVGRTCLDDQLCLAGGWKVKAGVPVMFTGWLAGLDVSCWNTGQDLSSGKP 22488
22487 QHPLEAFWAERFLDCPGSSSISGPAKKKRVQPARESPQRPTTHMGTEDERSRASVAGLRG 22308
22307 HFFPFGGGAFRCPGETLAKQVIFASVAMVLQSYDLRLIDPEEARKIEPGHRELPFGLHSF 22128
22127 DRPVPVEICKLSET* 22083
CYP5133A1 Fusarium oxysporum
97% to CYP5133A1 on AAHX01000914 (10 aa diffs)
see fungal pages for seq.
CYP5133B1 Glomerella graminicola
ET530821.1, ET595126.1, ET586230.1, ET611727.1
ET452524.1 GSS sequences
ET517409.1 may be the C-term but not connected
47% to CYP5133A1
MKVQSHVLSLSTPLSTILYVLPGEG
VRSLFRASKDLVPVPGIFDALTVFFGLTPADHHVFNHEHISAFEAKKDKRYSTFHEDPSR
RIMELQRHDFITFLHGENLRVVMDEFSLNL
NVSISSFSCSTIRAGNLPDLYVFLRDSIFRAEVEAL
YGKHMFAICPSLCEDFWAFYEAFPVISRGSPRWLYPAQYLSRDKMLHNLDKWRRWCNSSS
HQEDEELGNSVSSPIWGTQYVKNMVRRYEGLEFSDVGVSSVLLGFLFV (2)
TTANSIPAAVWMILHILLDKPLVSRLRQELLKESKAKDAPINYTALLSAPLLNSVYRET
LRLHIAGSIGRKAFSEGARLRGGSLSALQSGTTSLSANWLGGLDESVWNIGREIDGRTE
YPVESFWAERFLEYPDDPASGPLRK
LGGGAWRCPGEAMAKNTILVTAFLLLKELDVEIIDPVDAAKASSQHRTIPFGTHAFDRKV
PIRCWKRSQV*
CYP5134A1 Gibberella moniliformis 7600
AAIM02000130
53kb from a PKS
Not highly similar to any known P450, 36% to 526E1, new family
Also = Fusarium verticillioides
MFSPTPQTLSIIIVVFILTTL
83381 LIRRALLPKPIPGIVYREANAKKVLGNAWELLQWKKKHGEMFGYLANLAVELNEPVFQI 83205
83204 FVHPLGKPWVIVADNREAFDILSRRTPKEFDRSRFLRSLFMPLVPEFHFHMPTGDRWK 83031
83030 AHRKLVADTMSPAFLGGVAGPQMWKSTMKLIDLWRVKERLAKGRPFSVSTDIRKAAFEII 82851
82850 WAATFGFDSGSTSAQTELLETLPEFTNLPDMDHEVHFPVAPDPPVFKAGLALNDAMNIG 82674
82673 VQSLVPGLHLWLAYNLMPSLRAARSLKEAVIQDMIKQAINKFSNQTDLNWEDQGNLKR 82500
82499 HMKSAVDIVIAREIDSARKEGRTPELMSRTVQDELFSFMLAGNEIFTLTAWTLKFLTTH 82323
82322 QNVQKKVRDELREQCSAAVERGDAPTVSEIMSARLPYFEAMIEESTRCGSVTQTNIRTTM 82143
82142 QEVNILGHMVPKHTEILMLNNGPGSFMPSLSVDEEKRSESSKGTAGKIGQWNVKGMRDFD 81963
81962 PERWLVKDEEGRLTFNPNAGPRHSFGAGPRACF (1) 81864
81813 GRKWAALEVKIMMALIVWHFNLEPTPKPLSSFKPFPGVAHRPEMIYLRLSNV*
CYP5134A1 Fusarium oxysporum (temp 5134A2)
95% to CYP5134A1 Gibberella moniliformis
see fungal pages for seq.
CYP5134B1P Neosartorya fischeri
43% to CYP5134A1 Fusarium oxysporum, 40% to CYP526G1
one stop codon and a small deletion, probable pseudogene
Note: this seq does not have an ortholog in A. fumigatus
see fungal pages for seq.
CYP5135A1 Phomopsis amygdali
AB272062
PaFS gene for fusicoccadiene synthase
And related P450
For fusicoccin synthesis
Only about 34% to CYP65 members, 42% to 65AB1 Aspergillus oryzae
9629 MSPQAVNSLEKTCNLLNLQVLGLTLLFSK
9542 LFYNAYLHPLRKFPGPLLARLSRLYYSYYRSTGQLEWKTLELHKKYGSVVRIAPN 9378
9324 LVSFNAGTAWDDIYGHTTKRRSGRRLQKEAFFYLGAVAPNGEKNLGASSDEDHSRIRGV 9148
9147 LSSAFSEKAVFAQEDLLMRHIGFMVERIRSLNGIPTDAVRWLHHCTFDITTDLSLGA 8977
8976 SAKTLACDEWSPLAHLMFEGIKEGITAVEILRFAPFKYQAFSLLIKAFGKARLEAFQAAI 8797
8796 NQAHIRMAQATTDKEDKKPDFMSHIIKANKTSKALTPSEITANVALLLDVGSETTASLL 8620
8619 AGCLFYLTKTPHILEKLTSMIRKDFQTPQEINSKNLAQNSYLTAVLNEALRIYPPVAGA 8443
8442 TPRVTPPEGSQ (1)
IDGRYVPGNISVAVNQVAMNRSPKNFTNPDQF 8263
8262 VPGRWLGDGCFPDDQLQLCQPFSHGPRACLGRN (2) 8164
8108 LAWAEMRLIMGHLLWNFDVELSSESENWNSQKTWFIWDKPDLMIRFKSREGQ* 7950
CYP5135B1 Mycosphaerella fijiensis
JGI gene model e_gw1.2.701.1
50% to CYP5135A1 Phomopsis amygdali
see fungal pages for seq.
CYP5136A1 Phanerochaete chrysosporium
JGI gene models none
Clone name PFF_311a (my old scaffold 311a)
MSSLLVLVAISLALSQLIRFYRWLFHHSISYLRGPVADSFILGNVREFTYQESVGDLDFR
YMNEYGTAWRMKSILGSDVLMICDPKALQHVLHKSGYHYPKNTEARIGSFNVTGRSILWA
PNGDIHSRHRKIMNPAFTAQQLRSFLPLFRRGSNKMCQLWKDEVLAQAPTGMTIAVNQWL
ARTTLDVIGEAAFDFSFGALDDADNEVSKAYHNMLFADSLLYPSAWSTIFRGLWRFIPDQ
LLSYVRYLPTREYTRFRYTLNIINKVSKSLIDQKSEDLLSGDKSSKDVMSVLVRANSSEN
PRSQLSEEEMVSQMATLTLAGHETTANTITWLLYELAKHPEYQQKMREEIAVKRAEINAR
GDADFTMDDLESMQYLHAALKETLRYHPIVYHLAREASKDDVIPLAYPVTTIKGETVSEI
PIAAGQIIMPNIAAYNRLPQVWGDDAHEWNPLRFIDDSPEVQVRLGMFGNLMSFFAGVRG
CIGWRFSLIEMQAIVADLVENFQFSIPPEKPEIIRVPAGIMGPMVKGKMHEGLQMPLHVTPL
CYP5136A2 Phanerochaete chrysosporium
JGI gene model pc.142.11.1
MAAAALLIICWLVVNLRRLLTHNSIRHLRGPPSASTLFGNVTDTLYQASVGDVEFRWLKE
YGGAWRLRGLLGANILALADPKALQHVLQKSGYNYPKTRQLSVTLFNLTGRSILWAPTGE
IHARHRKVMNPAFSVPQLRSFIPLFRQSAKKLTQIWKDQVNAGHPDGVTLPVDRWLARAT
LDIIGEAAFDFDFGALDNTENEVSKAYHRMFADSQLYPSVWNLLFQATWSLLPEPLLYYI
RYLPTREYKTYRSTLSVMDKIAAQLIEERTREFGAGDPDKSRKDVMSVLVRANMSENPST
RLSDEEMRSQMFAMTLAGHETTANTVTWMLWELAKHPDIQEQLRQEIAEKRMEVTANGSY
EFALDDLESMPLLQAVIKETLRYHPISSFLWRVAAKDDVIPLEKPIVTTTGETITEIPVA
AGQVIMPSLCSYNRLAHVWGEDAHDWNPMRFLQGDTEKQTKVGMLSNLITFSAGVRSCIG
WRFSVLEMQAIVVELVENFRFSLPDNKPEIIRAPTMTMGPMVKGKLHEGFQMPLRVVPV
CYP5136A3 Phanerochaete chrysosporium
JGI gene model pc.16.161.1
MAVIDYTLHASSPLVLLACTVCVAVLAFRWYSSSTHGSIAHIRGPPVKNPILGNIRDFSY
QENVGDLDFAYMKEYGTAWRLKSSLGKSVLMVADPKALQHIFHKSGYLYPKTTPSTVRSF
LVTGKSILWAPDGNTHSRHRKIMNPAFSAPQLRSFLTLFRKSSSKLCQLWRDEISPEGST
VLVNKWLARTTLDVIGEAAFDFDFGAMQDNQNELSVAYDNMFTDATLHTSPWNAIFEALW
DYIPDGILKQVQHIPTREYARFKQTLGVFAKYSKRLIAQKSADLVSDTHSKDVMSVLVRA
NAAEDAGRKLNDEEMVSQMSALTLAGHETTANTISWLLYELAKHPDFQEKMHAEIVAKRA
EIVARGDEDFTMEDLESLEYLQAAIKETLRYHPIAFHLNRMASQDDVLPLAYPVMTTAGE
KVTEIPVRKGQAIMPNLAAYNRIPEIWGADAHEWNPMRYIENRTDAQVRVGMYANLMTFS
AGVRGCIGWRFSLIEMQAIISDLVENFRFGLPKDRPEVLRVPAAVMAPMIKGRMEEGAKL
PLHVTVY
CYP5136A4 Phanerochaete chrysosporium
JGI gene model pc.16.153.1
SGACVLCLAWLAYRWYRWTTRLNISYIRGPPVKSWILGGNVRDFAFQENVGDLDFKYVQE
YGLVWRMQQPLGAQVLMVADPKGDIHARHRKAMNPAFNNAQLRSYYPCFRRTSSKVCQLW
KDQILSQGPNGATIRVDRWMARAALDIIGEAAFDFDFGALDDSANELSAAYHNMLSADST
LRPSAAQAVFQGLWTHAPLRVLERVRHLPLRDIARFQHAMRVFNTYAARLMARGAAGAAH
GRDVMSVLGTAHANASADPRTRLSAEEVRAQMCALTFAGHETTANTTTWLLWELARHPPA
HQDSVRADTVRRRAHVAARGDADFGVEDLDALPCLEAAIRETLRCHCIVFHLNRVASQDD
VIPLSRPLTTATGKTVTEIPVAAGQVVMPNIAVYNRTRTKWDPTRFLDGRVDNPEVRLGV
YGNLRTFAGGVRGCIGRHRMIEMQAIVADLIGHFRFSIPDDKPEIVRAPSMLMAPMIKGK
EHEGSQMPLHV
CYP5136A5 Phanerochaete chrysosporium
JGI gene model pc.14.209.1
MFHGYLSATFQAQRRPGNIKDFTYQQNVGDLDFQWVKQFGRVWRMQSPFGTDILALADPK
AMQHCFHKADDQYNKRVESTVGSRMMMGKGLVWASGTTHERQRKIMSPAFTTAQIRSFLP
FFRAGAAKKWRDELFNHSTDGAAVPVNKWFSRATLDILGETAFDFNFGAVDDKDNEVTLA
FHTMLFANSCLRPPKWDLLFKRIWYFLPNPLLELVQYVPTKEQNRFRRCRLVVEKVSQQL
IQEKREALLAEAKSSRDIFSVLVRANVSENPNSRLSDEELIAQMGTLVLAGHVTTATTLS
WMLYELARRQDYQDKMREEIVAARARLQERGQQDFSMEDLENMHYVSSCLKETLRFHPPV
YHLFRQANTDDVIPLEQPVRTTSGKYVTEIPVAAGQQVLFSVCAYQRLPEVWGEDAGIWN
PMRFIDGNVDKQSKLGLYSNLMTFSAGSRGCLGWRFTIVETLAIIVELLEHFKFEPTEDT
AKVIRVPTGIMSAFTAGKEREGPQMLLKVVPIL
CYP5136B1 confidential basidiomycete
CYP5136C1 confidential basidiomycete
CYP5136D1 confidential basidiomycete
CYP5136D2 confidential basidiomycete
CYP5136D3 confidential basidiomycete
CYP5136D4 confidential basidiomycete
CYP5136D5 confidential basidiomycete
CYP5137A1 Phanerochaete chrysosporium
JGI gene model pc.5.122.1
(SEQ ON OPP STRAND FROM THIS MODEL #)
MNNLTAALILVALALWFACRRFTRTTLRDIPGPKPVSFWLGNLEQYFLGQAGEGDFHLQE
RYGRIARLHGSIGGEYLWISDPNALRYIFQTSGYRYAKQPERRALSRLHSGHGLVWADGE
VHKRQRKVMLPAFGAPESKALLPHFARAAEAVSVKWKDILTTAPSLSKELNVSTWLSRAT
MDAIGEAAFDYHFGALENTDTDIVRAYNNLMPIVFGAPTADAIFKRDALRIFRSSRIVEW
IYDRQRNPAVEKARECEELTLKIARELVENKAEALEQGKGSKDIFSLLVKANMTEDAKSR
LSEEEMYAEMRTILFAGHETTSTTISWVLLELARHLPVQERLREEILAHKRGGELSATDL
DGMPFLQAVVREALRLHPVLNQTFRQAEQNDVLPLAHPLTDRTGTVLTALPISKGTRVIL
SIAAYNRDTELWGSDAHAFDPDRWLDGRVKKVQTLGMYGNLLTFAAGVRGCIGWRFAVYE
IQTFLVELLANFEFRPTEDLKRLRREPCGVMVPTLEGDRGTVQLPLRVSLLDHKI
CYP5137A2 Phanerochaete chrysosporium
JGI gene model none
temp name PFF_88
MHDIFPLAVLLGALLWIVRRILSRSSIRDICGPEPESFWLGNLKQFFMRQAGEGDFELQE
RYGRIARLHGSIGGEYLWVADPKALQHIYQASGYNYAKQPERRALSRLHSGHGLVWAEGE
VHRRQRKIMLPAFGAPESKALLPHFIHIAESLSMRWKDILLASRDFAKELDVTEWLSRAT
MDAIGEAAFDCQFGALDNGGSEVLRAYNDLLPMVLGVPTTDGIWKRDAMRIFNSSAIVEW
IHDRQTNDVLQRARECEQMVMKVAKELVSSKAEALVQGKGSRAYFSLLVKANAAEDAASR
LSDEEMYAEMRTSSLAGHETTAMALSWALLELAQHPEVQSRLREEVRGCKRGEELSAAVL
DSMPYLQAVLREVLRVHPPAIHNFRQAVRDDVLPLAHPITTKSGSVLTELPIQKGTRLIL
SIAAYNRDPDLWGSDPHMFDPDRWLDGRVKKGQVVGMYGNLLSFSAGVRGCIGWRFAIYE
MQAFLVELVSNFEFGPTEDLKRLRREPCGVVAPMLEGEQGVQLPLRVSLANYDV
CYP5137A3 Postia placenta (brown rot basidiomycete fungi)
CYP5137A4v1 Postia placenta (brown rot basidiomycete fungi)
CYP5137A4v2 Postia placenta (brown rot basidiomycete fungi)
CYP5137A5 confidential basidiomycete
CYP5137B1 Postia placenta (brown rot basidiomycete fungi)
CYP5137B2 Postia placenta (brown rot basidiomycete fungi)
CYP5137B3 Postia placenta (brown rot basidiomycete fungi)
CYP5137B4 Postia placenta (brown rot basidiomycete fungi)
CYP5138A1 Phanerochaete chrysosporium
JGI gene model pc.65.27.1
MPLLSAVPAAALPLLGAALYVLWTFLALLVRQARSPLRHLRGPPSPSFLVGNLREMHDQE
NTALFARWEHRYGSTFVYHGFLGGARLLTTDPVAVAHILAHGYDFPKPEFIRDALASMAA
GHEGLLVVEGEDHRRQVRASPAFATPHIKSLSPIIWSKATQLRDVWIDLASSPSLTPAAT
PPGTKVDVLAWLARATLDVIGEAGFGYAFNSVRAAACPGDAAEDELARAFAVIFSTARKF
RLITVLQVWFPFLRRFVSIPPRCFLALPLKSSLSSDPSQQLSTNAMLCQIATFLAAGHET
SASALSWALYALARAPACQHTLRRELRALTLPADPSAADLQAVLALPYLDAVVRETLRVH
APVTSTMRVAAHDAAVPVGTPFRDAHGAQHAAIRLRAGDIVTLPLQAMNKWGADAACFRP
ERWLAHGDAPREPRGLWGGVMTFGTGVVANGNRSCIGYRFAVNDVVTRPCVKSEPHLGNQ
MPLRLRRVAVEETVGDSSGDGAPRTVS
CYP5138A2 Postia placenta (brown rot basidiomycete fungi)
CYP5138A3 confidential basidiomycete
CYP5139A1 Phanerochaete chrysosporium
JGI gene model gx.38.22.1
MGYPLAVYAVGALVALIVYSVGPTVWHVLTSPLRHLPGPPNDSLLWGNMAAIQNEEISVP
QARWVKQYGHTISYRGVFGMWRLWTVDTRALNHILTHHLIYQRPLPSRYQLSRLVGPGVL
VTEEERHKHQRRVMNPAFGPAQVRELTEIFTEKANEMRDVWYNEITKAGGASAQVDALSW
LSRATLDIIGRAGFGYDFEALTGASNELNQAFSTLFARPIARHRFFARIGMQLIEQRKAA
ILAEKGKDVERKDLTGRDLLTLLIRANMATDIPEDQRLSDEEVLAQVPTFIVAGHETTST
ATTWALFSLAQMPEIQRKLRNEMLTIDTDTPSMDQLNSLPYLDAVIRETLRFHSPVPVTT
REAMADDVIPLGTPTVDRYGRTIDHINIKKGDLVFVPILAINRSKEIWGEDVDDRPERFE
NVPEAASTVPGVWGNVLSFLGGPRACIGYRFSLVDIVTRPVMTGPDGKTRGALPLIIRPYRP
CYP5139B1 Cryptococcus neoformans var. neoformans B-3501A chromosome 6
AAEY01000032
CNBF3400
EAL20013.1
42% to CYP5139A1 Phanerochaete chrysosporium
see fungal pages for seq.
CYP5139B1 Cryptococcus gattii
CNBG_1699 Transcript 1 Broad Institute
91% to CYP5139B1 Cryptococcus neoformans var. neoformans B-3501A
MELFKTLHLETSQFFSNCIQPSPVACIALYTFTGVTILLFTIYLWLWPFQYATLHFRNLP
GPPSDSWFWGVVPTLIKSPPSVPHSMWTDEYGPTIRYRVALGAQRFLTIDPTALNYILSH
IDLFPKPSRVRKALSDLLGNGLLTAEGYTHKKQRKALNPSFSPAAIRGMVPVFYDKAYEL
KAKLLGIISDDETEQASPTPCIKEDEVEGGKKIDVMKYLGKTTLDVIGIVGFSYDFKALS
EPHNELSEAYSKMFQASMDANFWDFLRGAIPLVNKLPNKRATEIAARKAVTLRIGKKIVE
DKKREVMSAHSEGLEKREDIGNDLLSILIKANMASDVKPEQKLSDEEVLDQITTFMLAGN
ETSSTALTWILYSLTQHPECQERLREEVLAVADDRPSLETLNSLPYMDAVIRETLRLNAP
APGTLREAKQDTVIPLSMPVTGRDGKQINSVRINKGTVVFIPILTVNTSPAIWGPDARDF
NPDRHLKTASNSFGGANMHVPGVWGNMLSFLGGARNCIGYKLALAEISTILFVLMRSFEF
QELKSKPEVEKKASVVMRPRIKGEESAGLQMPLMVKPL*
CYP5139B1 Cryptococcus neoformans serotype A
94% to CYP5139B1
see fungal pages for seq.
name revised from CYP5139B2 since it is an ortholog
CYP5139C1 Sporobolomyces roseus
JGI gene model estExt_fgenesh1_pg.C_10483 gene model revised
39% to CYP5139B1 Cryptococcus neoformans
see fungal pages for seq.
CYP5139D1 Postia placenta (brown rot basidiomycete fungi)
CYP5139D2 Postia placenta (brown rot basidiomycete fungi)
CYP5139D3v1 Postia placenta (brown rot basidiomycete fungi)
CYP5139D3v2 Postia placenta (brown rot basidiomycete fungi)
CYP5139D4 Postia placenta (brown rot basidiomycete fungi)
CYP5139D5v1 Postia placenta (brown rot basidiomycete fungi)
CYP5139D5v2 Postia placenta (brown rot basidiomycete fungi)
CYP5139D6 Postia placenta (brown rot basidiomycete fungi)
CYP5139D7v1 Postia placenta (brown rot basidiomycete fungi)
CYP5139D7v2 Postia placenta (brown rot basidiomycete fungi)
CYP5139D8 Postia placenta (brown rot basidiomycete fungi)
CYP5139G1 confidential basidiomycete
CYP5139G2 confidential basidiomycete
CYP5139H1 confidential basidiomycete
CYP5139H2 confidential basidiomycete
CYP5139H3 confidential basidiomycete
CYP5139H4 confidential basidiomycete
CYP5139H5 confidential basidiomycete
CYP5140A1 Phanerochaete chrysosporium
JGI gene model pc.96.21.1
MNASSIDFFPRNLATSPVFSAKPFLLALSLISTYLVSVAFYRLFFSPLASIPGPWYAAVS
DLWITTHVLRMQQCRVVQDLFDTYGPIVRIGPNKVAFCDAGTMRSVYCVHKFDKSAYYKS
LLTNNNDHAMTTLPHAEHAIRKKTYAPHYTPANLALFQPELNDLALKLTDILSIRSSSVD
VLDLFRHLMVDVIACTVFGSRSGSLDNWNKGVRDPLSIAVYDFPKRGIMVRLCLSSPVTA
SDNHIRSGAQCLLGPGSFIAGVDTSSTSLSYMFWELSRRRDVMQRLQAEIDEIMPDPRVI
PDATVLNRSEYLNAFVKECEYACHPCPAEILRDPIALHFDMMGYALPPGTIVATQAWSMH
RDEDVFPSAETFLPERWLVDPHADREVEEERLARMHLHLVPFGVGTRQCGGQNLAHLMIR
IVVAVVVRNCEVRADVRETNERSMSMRDAFVSPLLWLLLGSERS
CYP5140A2 Postia placenta (brown rot basidiomycete fungi)
CYP5140A3 confidential basidiomycete
CYP5141A1 Phanerochaete chrysosporium
JGI gene model pc.181.9.1
MISDTFALAISSGLSLFLCLKAFIDYRAGLRSINHSYLPGFRALISSFGILGLFFKEPKR
GLWGGRRRFWLRKHLDFEEAGVDIISHIAFLPSVSTYLLLADAAAIKEVTGHRARFPKPT
YKTLRIFGGNVLASEGEEWKRHRKVVGPAFSEHNNRLVWNETVKIVNDLFANVWGSQSEV
YVDNVVQSVTLPMALYVISIAGFGKRALWQADGNLPPGHKLSFQDALHILGTDLWIKAAT
PTLLMNWAPTTRIANVKLAFDEVKQYMLELIQERRNSEKRDERYDLFSSLLDANDLNEDG
NGNVTLTNDELLGNIFIFMLAGHETTAHTLAFTFGLLALHPDYQETVYQQIKSIVPDNRP
PMYEEMNSLTECMAYETLRLFPPTATIPKIAAEDTYLVTIDRAGNRVVVPVPCGTALHLN
VIALHHNPRYWDNPSAFKPERFRGDWPRDAFIPFSTGSRSCIGRRFFETESIAILTMILS
RYKIELRNDPRFADETYEERWQRVLRVKDGLTPA
CYP5141A2 Phanerochaete chrysosporium
JGI gene model gx.37.18.1
MFSNTFALAITSGLLLSCLKAYMDYRAALRSINYHPGSCALIPSFGMLGLLFKEPRRGLW
GGWRRFWRRKYLDFQEAGVDIISHIAFVPSVTTYLVLADAAAIKEVTGHRARFPKPSYEF
FRIFGGNIIASEGDEWKRHRKIAAPAFSEHNNRLVWNETVKIVCGFFENVWGSQAEVYVD
DVVQSLTLPMALHVISIAGFGKQTVWRADGTLPPKHKLSFQDALHVVSTDLWIKFVMPTM
LLDLAPTKRIAKVKLAFEEVEQYMLELIQERRDAEKRDERHDLFSNLLDANDSDENGDGS
VKLTDEELLGNIFIFMLAGHETTAHTLAFTFGLLALHSDYQEKVHQQIKSIMPDNRLPTY
EEMHLFTECTAVFYETLRLFPPVTTIPKISAEDTSLVTTDRAGNRVVVPVPCGTSLHLSV
VALHYNPRYWDDPYAFKPERFHGDWPREAFIPFSAGARSCLGRRFFETEGIAILTMILSR
YKIELKDDPRYAHETYEERWQRVLDVKDGLTTT
CYP5141A3 Phanerochaete chrysosporium
JGI gene model none
temp name PFF_77b
MNSVLVILLSTILLLCLKTYVDLRTALRAVNYHPGFKSFISCFGVFGFAFKEPRRGLIGG
SLRFWHRKHLDFDEAGVDVIHHVSFFPRVSTCLILADPAVIKEVTSHRALFPKPLYHELR
LWGGNIIASEGDEWKRHRKVGAPAFSEPNNRLVWNETVKIMVDLFDNVWGSQDTIIVDHV
VDAFTLPVALFVISVAGFGKNASWQSDLLPPSGHKLSFKDAIHVVSVDMFIQVVTPTFLW
KLAPTKRIADVKLGFEELEKYMLEMVEERRNAPKKEERYDLFSSLLDASDSDADGGARLT
DRELLGNIFIFLLAGHETTAHSLAFTFGLLAMHQDYQEKLYQHVKSVIPDGRLPTYEEMN
KLTECMAVFYETLRLFPPVVGVPKVVAENTTLVATDFTGKRRAIPVAAGSDIHISILALH
YNPRCWDEPHAFKPERFHGNWPRDAFLPFMAGPRACLGRRFFETEGIAILTMLVSRYKIE
LKDEPAFAHETYEERWDRLFTVKQGITLA
CYP5141A4 Phanerochaete chrysosporium
JGI gene model pc.181.12.1
MGTLAWVVLSFCLFYCVQKYLEFRAVVRSIHDHPGFRTLLPPYGIFGFLFKRPIPGITRG
GMSQWRGKYRDFEAFGMDIISATSVIPTARNAFLVADPAAIKEITSSRTRFPKPVAQYRV
LTFFGANIVTAEGDEWKRFRKITAPAFSERNNRLVWDETVKIMLDLFENEWAGKDTVVVD
HAVEVTLPWIALFVIGVAGFGRKMTWQEDSKLPPGHQLSFKEALHYVSTAVFVKLATPAW
LLTWAPTERMRRTNLAFKELEQYMLEMIQTRRNSEKKEERYDLFSNLLDASEDGSDGHAR
LADEELLGNIFIFLLAGHETTAHTLAFTFGLLALYPEQQDKLYKHIKHVIPDGRIPAYEE
MNLLHESIAVFYETLRLFPPVTGIPKVAAEDTTLVTTDHSGNKVVVPVTKGTGISLHVPG
LHYNPRYWDDPYEFKPERFHGDWPRDAFLPFSSGARSCLGRRFFETEGIAILTMLVSRYK
IEVKEEPEFAGETFEQRKERILAARGGLTLTYVCSPPHLRNLLNLPLR
CYP5141A5 Postia placenta (brown rot basidiomycete fungi)
CYP5141A6 Postia placenta (brown rot basidiomycete fungi)
CYP5141B1 Phanerochaete chrysosporium
JGI gene model pc.37.84.1
MQQHLLFAAGLICLFLVKRCIEYRRAIRAIHNYPGVRAVLSNSSGLGYLCKRSIPGLAVG
GARLWVKRYSDFCRYGADIVSCVAVLPRTEILLFVADPAAIKEISSDKTRFSKPTELYEL
VNIFGRNIVTTEGDEWKRHRKIVAPAFSERNCELVWEETLHVMIGLFNDVWGSDSIITLD
NAFDITMPISLFVVAASAFGRRIPWTEGGLAPPGHHMSFKEALHIVSTGTVIKAVLPKWL
LNLGPSQYIREVRDAFREMEAYMREMVTENMLDDTKSRRDLFSSLVHAGQDSPGQEALLT
DAELLGNVFMFLLAGHETAASTLCFALGLLALHKDEQDKLYDHIRFTLGEKDVPAYSDLT
SLSYCSAVLYETLRLFPPVIGIPKKATEDTVLSTVDRDGNHIAVPVPVGSSVAIHVPGVH
YNPRYWKDPAAFRPSRFFGNWPRDAFLPFGAGSRACIGRRFFETEAITALTMLVVRYEIS
VTDEPQFRDETAEQRRERVLSATQELTLT
CYP5141C1 Phanerochaete chrysosporium
JGI gene model pc.81.19.1
MASRLLVLLAALVLFALRAFARFRRAVHAVSYVSSALRSVNHPGYRTLLNTLGPIENFFP
RIPGVAPGAFHMWKRKHRDFEEHGWDVITY
VAAFIGSSTNFYVADADVIK ()
EITTHRSRFPKPIEQYKVLTFFGGNIVASEGEHWKRYRKIAAPAFSE ()
RNNKLVWDETRLIMQDLFTNVWGERAEIYVDHAVDITLP ()
IALFVIGVAGFGRRIPWQDEDVVPAGHTMTFK ()
TALHTVSENVFTRLLIPDWLLRAAPTARLARIRDAFAELEQYMREMIRARRERPAREERH
DLFSSLLDASKDADVRLQDSELIGNMFIFMLAGHETTAHTLCYMLAMLAMHPEVQDKMYE
SIRGVTQNGRLPEYEDMRSLSYCEAVLYETLRMFPPVNSIPKSVAEDTAITITNADGERT
TVPMPKGSSISIHTPGLHYNPRYWPDPHTFRPERFLAADWPRDAFLPFSAGPRACLGRRR
FSETESVAAAAMLVLRYRIAVADEPRFAGEGARARFERVTASRPGVTMTCVFCAPLWVVV
GTDELCCRPTRVPLVFRRR
CYP5141C2P Phanerochaete chrysosporium
JGI gene models pc.167.26.1
genewise.20.89.1 [whiterot1:25284]
pseudogene FRAGMENT
91% TO 5141C1
VAAFIGSNTNFYVADADIIK (0)
EITTHRSRLPKPIEQYKVLTFFGGNIVASVGEHWKRYRKIAAPTFSE (0)
RNNKLVWDETRLTMQDLFTNVWGRHAKIHVDHAVDITLP (0)
VAGFGRRIPWQDEDVVPAGHTMTFK ()
TALHTVSENVFTRLLILD
CYP5141C3P Phanerochaete chrysosporium
JGI gene model pc.67.69.1
pseudogene FRAGMENT
84% TO 5141C1
VASFIGSNANFYVADADVIM (0)
GNTTHGSRFPKSIEQYKILTFFGGNIVASEGEHWKRSRKIAAPAFSE (0)
RNNKLVWDETRLILQDLFTHVWGKRAEIHVDYAVDITLL (0)
IALFVVGVTCFGRRIPWQNEDVVPAGHTMT*LK (0)
TVLHTVSENVFMRLLIPD
CYP5141D1 Phanerochaete chrysosporium
JGI gene model pc.81.21.1
MLLILWALLAAVVYHAAARLVRLRRLLVKIRFHPGQRAATSIYGAATFLFPWRIPNLTPG
ANLLFDEKHALLARHGLDVVTSVSTHPMRAVFVVADPAVLRDMAAARSRYPKPVELYGSL
SLYGPNIVASENDAWKRYRRICSPSFSERNNKLVWEETVRVVTELFDTWEGRQEIDMEDA
LTMTLSITLFVISSAGFGKPITWKGGDERPEGYAMSFKDVIYHMSTGVFIKIATPQWLLN
LGLTEKMRNTNVAFKELGMYMSDMIRERRESQQREDRGDLFNGLLDAGEEDEKLKLTDEE
LMGNIFIFLIAGHETTGHTLCYALALLALYPDEQEKLYQHIRTLCPAGELPVYDDLRNYT
YALAVLYETLRMFPSVVGIPKVASEDTCVQTMNDAGQLVEVFIPEGSDIVFDTPGLHYNP
KYWTDPYTFSPSRFMAPDWPRDAFLPFSGGPRACLGRRFARFAEIESIAVLVLFVSQYTI
HLKEDPKYAGETEQQRRERVLKSVPGLTLT
CYP5141E1 Postia placenta (brown rot basidiomycete fungi)
CYP5141E2 Postia placenta (brown rot basidiomycete fungi)
CYP5141F1 confidential basidiomycete
CYP5141F2 confidential basidiomycete
CYP5142A1 Phanerochaete chrysosporium
JGI gene model ug.79.41.1
MDDVNLFIRARTLLDSVLVLILTSIGYAVANAVYNVYFHPLSKFPGPRMAAASRWWKTYV
EVYRDESIVDRLFHLHEKYGNVVRIAPDELHFSDPAVYNAIYSPKSRWNKDPLMYAPFGF
GSHRSMFSTVEYQPAKKRRDLAAPHFSRKSVLNLQGVIQAGVSNLCDAMAQRAAEGKPTD
IYSAFRCLNFDNVTSYCFGWSLHMVRSPDFSAEPVQNMQDMHSSYQVWKHFLWLRTPMRL
LLSVLGKRPMPYFRVIMEQVDGYLERPEELDNAPHSLIFHSLMDPAQSTKLDKQSVVEEA
NLLIIAGTDTISNASALGTLFLLSDGGYMRDKLQAELKAIWPRLDDKPSLEVLESSAPYL
KAACKESLRLSHGVMSPLLRVVPSQGATLGGHFVSGGTKVGICNAFVHLNPALFPDPHVF
RPERWPEPGAESLDTWLVAFSKGPRSCIGINLGWCELYMNLANLFRRFDLKLDHRVQVLFLGGS
CYP5142A2 Phanerochaete chrysosporium
JGI gene model pc.79.57.1
MNVWARVSEGWTALEVILVALLTSIGYVVTTALYNIYFHPLSKFPGPKLAASSWLWKAYV
EVIKGESILDRLSKLHEEYGPVVRIAPDELHFNDPAVYNEIYTARSRWNKDDVMYAPFGK
DTSIFTTREFREAKKRRDLSAPHFSRKTVLSLQGLIQEGIDEFCEVITKRDADSKTTDIF
RAFRCLDFDNVSSFCFGWSEHAIQAPDFNSAAVEELQHSNKDFQFWKHFLRLPLPVLLLA
SRIKNQIATYIDKPEELDKTPHPTVFHVLMDSSHGTRLSATAMAEEASLFLIAGTDTTSN
ASALGTIFALSDNGYMRNKLKEELKSVWPRLEDKPSLEVLESLPYLKAVCKESLRLSHGA
MSPLMRVVPQQGAVLGGHFVPGGTKVGMAHTFVHFNPTLFPEPHTFRPERWLEPGAEALD
TWNVAFSKGPRSCLGIKSLAWCELYMNIAHIFRRPVRPYDLWHRDCFLPYLDGVDLLVYATPSTD
CYP5142A3 Phanerochaete chrysosporium
JGI gene model pc.24.27.1
MDVVRQALEGRTTKEYAGLALLAFAAYVVANIIYNLYFHPLAKFPGPRAAAASRWWKAYV
EVYKGESIVDRLFELHAEYGDVVRITPDELHFSDPKVYNEIYNTRSRWDKDGEMYAPFGG
NSTMFTALRYHDAKKRRDLTASLFSRKSVLSLQGSIQEGLDELCDIISARSAAGKTTDLF
RAFRCLNLDNVTSFCFGWSLHTVRAPDFRAPPLEEVQNSHGGYQFWKHLMLFRAVLLPKL
KEQVDALVARPDELEAAPHPIIFHSLIDPAHGAKLSAQELMEEANMFIVAGIDTTSNATG
AGVIGVLSNPSTYDKLKTELRTAWPRLDEKPTVEVFESLPYLKAVCKEALRLSHGITSPM
LRIVPPQGATLAERFVPGGTQVGVSHLFVHLNPTLFPDPHAFRPERWLEPGAESLDTWLV
AFSKGPRSCLGINLGWCELYLNIANLFRRFDLKLEGRAKAFLDGPRARASGDWKDCFLPC
FEGPDMLIHTTPVAD
CYP5142B1 Phanerochaete chrysosporium
JGI gene model ug.20.42.1
MLNLSLDSSSVLSLVWTASPWLLLSWILYTVLMAVYNLHFHPLAKFPGPKMAAASEWWLA
YVEVIKQESLSKKLWELHEQYGANATQLHFSKPAAYNEIYNVKNRWDRDMKLYHIFADEV
STLTIPDYARAKKRRDLTTFLFLARILLRQLDTVCENIDKHIKEGKPVSIFKAFRCAAAD
VICTMCFARSMNATSEPGFNAQVVTAIHAAFPVIMVFKHFPLLQTLSRMVPPLLLSSLRP
ELNGLMKMRKMLTDQVKEVKAHPEILKESQQVTIYHELLKDPKNIPSDTSLRDEAVLYVT
AGMDTSSDTLTLATINVLSRPDVHARLMHELVEAWPHLEDAPPRYEQLEKLPYLTAVLKE
SLRLSHGVVQPMTRVVPREGAYISGHFIPGGSIVGMSSIFVHWNEEIFADARAFKPERWL
DPEADLDPWLVAFSKGPRSCLGVNLGWCELYMSIAAIFRRYELKLNGIG
CYP5142C1 Phanerochaete chrysosporium
JGI gene model pc.20.56.1
MLRLLVDNGLVSALARYGPAMLISIIVWTLGRVVYNLYFHPLAKYPGPRMAAATEWWQAW
LEIFKAESLSLTLLELHAKHGGDIVRIGPNELHFSRPSAYHEIYTSKNKWAKNPAFYRYI
VSPTESTFSTCEYDKAKKRRDITLPIFSRKSILGMQHLVQECIDSMCENIDKHISEKKSV
NILRAFRCCALDAVTSLCFARNTRATSEPEFRAPIEVAMDFSLPLTPVLKHFPMVQVVMS
WLPPDVLLWADARLGGFVQLRKMLDAQVEEILRDPDVLASAEHPTIYHAFLAHAPTPSVA
ELRDEALVYVHAGTDTSSDALAVGTLNVLGRPAVLARLRAELDTVWPRLDERPRYEALEA
LPYLTAVVKESLRCSHGVVHPMTRIVPRGGARISGAHIPAGTIVAESNIFVHWNADVFPE
PHEFRPERWLEGKTPSGESLDNWLVPFSKGPRSCIGINLGYCEIYMTFANLFRRYDLSLD
GVKPSDWKWRDCYLPHYLGPEMKVVATPRLS
CYP5142D1 Phanerochaete chrysosporium
JGI gene model ug.43.40.1
MAGQLMAHSLDVLSTMFTLLSLYAITRCIYNLYLHPLSRFPGPKLAAATTWWRAIGEVFM
WENLTDKLVELHNTYGPCEIVRIGPNELHFSRPSVYHEIHNPRNKWNKDPAVYNVFADTE
STVSICNYEAAKRRREMTLPLFSRRSIVDAHDLIRSCLDKMCTNIDSIASSGEPVHFFRA
FRCFALDAISLMCFGVSPEASLAPHFRSTLDGAMHVALHDALLVKQFPLLKYLMAYSPQW
LVTYTRPALRSYFEMRRVRLSLPTLRQLVYLRSTIAAERSSAGSQEGTPLSEPVLRDEAF
VFVNAGADTVSNAITVGVLNVVDNRDVYTKLKHELRCAWPNLKVSPRWEELERLPYLRAV
VKESLRMVIGVVHPMTRIVPPQGAVLCDMFIPGGTSVGISHYFLHHNEDVFPQPRTFKPE
RWLARESDKEHMLVSFSRGPHSCLGVNMAYCELYLAFAYFFRRYDVELNGVRYVHVSSRETELTN
CYP5142E1 Phanerochaete chrysosporium
JGI gene model pc.167.13.1
MDSWLSWHGVAAAVVAAALLLVVYRVYFHPLAKFPGPKLAAATHWYSAYYEVWRDGALVE
HLQELHKQYGPVVRITPDEACISYTDIYVRGTRFTKDPGFYGFMHGDRSSFWMLDPQKSK
ARRDVLLPLFSRRAVLSLEDVVQKKVRALVTAVLTQGADDTSVNMHRAYRSATLDTILAY
AFAQERGMLDVPGFAHPLVREFERAFPLALILKHLPWLHRVSTAVRAVKYMLVRTDPDDI
VRDTAAQIDGLLADPDRLAELPHETVFHRFLAPHAKGAGGEPPSRRDIVDEAINIFAAGS
DSTGHTCAMGTAFVLAYPEVHKRLVRELEEAWPDRDAEIRLAQLEKLPYLTAVIKESLRM
SHGVVMPLPRVVRPNEAIIDGISVPAGAVVGMGATFMHYNPEVFPQPYTFDPDRWLQPDV
SRLEQHLVPFSKGLRSCIGLTLAWCEMYLVFGYIFRLLDMQLDNMTLEDIKVKYHFTPTV
REKDMLRCMVRARES
CYP5143A1 Phanerochaete chrysosporium
JGI gene model gx.20.61.1
IILIILATISYRLSPLHPLARYPGPILDKSTSLRLAYLAFIGQRAQYVTELHERYGKIVR
IGPNKLSINSLDVVHPIYGSSQAYDKSESYRPGLSAEGSIFFARKKELMRDGDPEGVVES
GHKAILMFETYCDSFGEVPALFDILSVLPTGEAYQLVEKRAATHLKDRIKVHPHDGWDMC
SFFLAQREGHNYPPMNEVDLNANTVVAFEAGGDTTAGFIIITMFHLLRYRQAYDKLKEEL
DGAFPTGSVSVEEYSHLAELPYLGAVINEGLRLGAAFPSFPRVVPKGGAMLAGEFIPEGT
MVGVPIYTQHYSPDNFWPEPREFRPERWFEDGLGPGTITRQAAFMPFQFGPFGCPGKALG
LRLMSVVISNLLVLSYDLSFPPDFDPEAFLNGWINTRTNIFRIPLRVEAKRRPW
CYP5143A2 Phanerochaete chrysosporium
JGI gene model pc.20.120.1
temp name PFF_33b
MFNSFGPAHVLLPPLALSVIIAVAAYRLSPLHPLAHFPGSWVDKVTSLRVAYFALTGHRA
EHVTSLHDKYGVVVRIGPNRVSINSSDVIYPIYASPQAFDRAASYRPGLIHDGSLLFSRK
RHWDGALKDRVDQLIDCIARRQDLRGVVDLGEFMRNGDPHNICRSAKDSIVLFEVYSSSL
GEIPALFDIASVLPVTAEYRKVERHFQKHINERMQIKSHSDWDFCSFFMAQREDAQYPPL
SKPDLNADAMVAFEAGGDTLAGFLSIIIFYILKHQPVYQKLRAELEQAFPLGEIAQDQYA
SLTEIPYLVAVINEGLRLGANFAGFQRVVPQGGAVLAGQFIPAGTVVGVPAHLQHIHPDN
FWPTPLEFRPERWFKDGLGPGTITRQSAFMAFQFGPFGCVGKTFAYRQLNVVLSRLLLAY
DLTFALDFDSKAFVEGWLNIRTTIFNYPLKVQASRRQW
CYP5144A1 Phanerochaete chrysosporium
JGI gene model ug.24.32.1
revised 8/15/2007 at I-helix micro exon, also removed one
small intron after AGVYL and added a micro exon VDVIPA
MELPAHTKYLLACLAFAIFVLLHSKRRRPRYPPGQRGLPLVGNLWDIPTEYAWVKYREIG
AQLGSDIIHFEVLGSHYVVLNSDKAVKEVLEKRSHNSSDRPQTVMLQELTGWHRNWALLE
YGDYWKDLRRIFSQYFRPSAVPQYHSKQTKAVRRFLNLLLNSPDDFTKHIRYLAASAILD
VVYGFDVRPGDPRIELVERGVHTLTDISAGVYL (1)
VDVIPA (1)
LKYIPAWFPGASFKRKAAGWKVLVDAVYEVPYSQYKDAMREGTAKPC
2461961 FAGTLLSEANPDGDLDETFRCLTGTAYV (1)
GGADT (0)
2462165 VSSTLLTFMLAVTMFPETQDPAHEELDRVLGRKRLPDIRDRDDLPYITAM 2462314
LHEVLRWHPVAPLTLPHRLTADDEYEGYHIPAGAVVFGNAWAILHDPATYGDPDVYAPAR
YLTADGRALRADVPYPLEGFGFGRRVCPGRPFAHDILWLALAHVLAVFRVGRARDAHECE
VPPRGVFTPGLISVPEPFGCRFVPRFPGAEELIRQSAMPE
CYP5144A2 Phanerochaete chrysosporium
JGI gene model ug.24.29.1
revised 8/15/2007 at I-helix micro exon and at VDVFPI,
AND KQSIMVNEL, AILRDED
MEDTSRSLVGPSLWAVFALGLLFAFCLRRQPRYPPGPRGLPIVGNVFDIPMNVGWKVFRD
VSRCFESDVIHYEALGSHLVVVNGAKAAKELFERRANNYSDR (2)
KQSIMVNEL (2)
TGWHRNWGQLEYGDRWRQHRRLFHQHFRPMAVSQYHPRQVKGVRVLLRALSESPEDFQRH
IRFMAGATIMEIVYAYDAQPGDPRIKLVEDAVDTLTFVVNAGVYL (1)
VDVFPI (1)
LKYVPNWFPGASFKRQAAEWKKLVDALYEQPYQEFKATVKEGN
2465265 AKPCFAATLLSSVENDEDIENLEELFMGLTGTAFV (1) 2465369
AGSDT (0)
2465493 TIASLNVFILAVTIFPEAQRSAQEEIDRVLERKRLPTMEDKVLLP 2465627
HVTALVHETLRWHPPLPLAAPHRVIEDDEYEGYFIPAGTTIIGNAW (2)
AILRDEDLFPDGDSFKPERWLNEAGALRDDLPYPMETFGFGRRICPGRHFANDVLWLAIA
NILTVFSIERALGEDGQPIVPEAKFSPRLISK
PEPFKCAFKHRFSGAEDMIRLAAIVEE
CYP5144A3 Phanerochaete chrysosporium
JGI gene model genewise2nd.24.5.1
REVISED AT PRSVMLHEL 8/16/2007
MELPPVPHPLIAYLCAGLLLAGLVVTRLRRRRHYPPGPKGLPLIGNLFDIPTDYAWKIYR
AFGDQYGSDIIHFEIFGTHLVILNSAKAARDLFEKRSSIYSDRPRSVMLHEL
TRWGRSFGFMQHGDEWREHRRLFNMHFRPSAIAQYHAKQKSAVCTLLRSLLDAPEQFREH
VHFMAGDVIMGIVYGFDVQPGDSRLQLVEKAVMTLNQIVNAGVYL (1)
VDVIPA (1)
LKYIPAWFPGAGFKRHAAEWKKLVDDMFEIPYRESMKSLQEGKCESSFAASLLAQLEGQE
SPDNIERIAMDVLGTTYVAGSDTIITATSTFLLAMILHPEVQITVQAELDALLEGARLPN
ISDKAALPSVTAVLQEVLRWNPGLPLVPHRVVADDEYKGYHIPAGAAVIGNTWAMLHDET
TYPDPEPFKPQRFLNEDGTLNADVPYPTDVFGHGRRMCPGRHFAHDMLWLTIASILTVYK
VERDVDEDGQEITPTASFTSRVPTPFRCRFTPRSASAESLIRSSGVSTE
CYP5144A4 Phanerochaete chrysosporium
JGI gene models pc.24.8.1 an gx.24.6.1
revised at micro exon 8/15/2007
ADDED KQQSVMIHEL AND REVISED LAST INTRON BOUNDARY 8/16/2007
NOTE THIS GENE IS COMBINED WITH CYP5144A5 IN JGI BROWSER (e_gww2.1.398.1)
MEQSTLHILPYLCASIPVLVCLLVLRLRRPHYPPGPKGLPLVGNLFDVPLSHGW
VAYRELAKQYGSDVIHLEILGSHIVIINSAKAARDLFDKRSNIYSDKQQSVMIHELTGWHRN
WGFMAYGDYWRKHRRLFHRHFRPAAVPQYHSAQAKGVHNLLKLLMRSPERFREHIRF (2)
2473972 MAGSTILDVVYALDVQPGDSRIELVERAVHTSTEIVAAGVYL (1) 2474097
VDLFPI (1)
2474217 LKHIPSWVPGAAFHRKAAAWKALVDRMYEEPYNQFKASM 2474333
KDGNAKACLTASLLMEAESTHQLDAIEDILISVTGTAYGAGTDTAVASLNTFMLGITMFP
HTQLAAQDELDRITARQRLPTMEDRENLPHVTAILQEVLRWNPAAPLGLPHRTVRSDEYN
GYFIPQGATIIGNSWAMLHDEAIYPDPGSFKPERFLTEDSTLRSDVPYPIEAFGFGRRIC
PGRYFAHDLLWLTIAGILAVFRIERARDEQGDEIVPAGDFSPRFIS (2)
SPEPFQCRIVPRFAGAEALIHGTGLLG*
CYP5144A5 Phanerochaete chrysosporium
JGI gene models pc.24.9.1(genewise2nd.24.7.1
NOTE THIS GENE IS COMBINED WITH CYP5144A5 IN JGI BROWSER (e_gww2.1.398.1)
MEWSLSLGYALLGLGIMWVVKYAQRPRRRYPPGPKGIPILGNVFNIPLENSWISFDQWSR
QYASDIVHVEALGKHVYVVNSARAAKELFDGRANVYSDKEQSVMMLELCGWSRSWAMLPY
GNYWREHHRLFHQHFRPQSMVRYHEKQRRGARRLLQLLLDTPEDYEKHMRYAAGSTILDV
VYSFDVQPNDPRIELVEAALGTANDLMHAGIYL (1)
VDIFPL (1)
LKHIPTWFPGAQFKRLAAKYKRLVDNMYTVPYSQLKASVKLGTAQPCLVASLLSEADEHV
TPERDEIFMNLAGTTYAGGTDTIVIALSIFILAMILHPEQQVAVQKEIDRVVGRDRLPEL
ADRESLPRVTAVIQEVLRWHSPLPLATPHRATSDDEYNGYYIKAGSVVIGNAWAMLHNEN
VYPDPASFKSERFLTPDGKLRDDVPFPIEAFGFGRRICPGRHFALDSLFLLVSHILAVFT
IEHAVDADGHIIPVEPEFEPQAFSPPKPFKAQFKLRFLAAEDLIDGSALE
CYP5144A6 Phanerochaete chrysosporium
JGI gene model pc.24.10.1 revised at micro exons 8/16/2007
MLTALSCVFAEALAVWAVSSWTRPRHEYPPGPKGLPFLGNMFDIPMKYGWVTFANWSRLY
GSDIVHVQALGKHIYVINSAKVAKDLFDGRPHIYSDK (2)
EQSVMTQEL (2)
SGWKRAWALSPYDDEWREYRKLFHQHFRPSAVQQYHHKQTKAVRRLLQLLLDTPEDFLAH
LRYAAGSSLLDVVYSVDALPGDLRITLVEKAVHTFAKLLETGVYL (1)
VDVAPI (1)
LKHIPAWFPGADFKRQAAEYRQLVDDMFKVPYQQFKDAWRRGTAQPCFAASLLTDADPLD
GSEHEELFINLTGTTYAAGSDTTVAAMSTFMLAMALHPEVQRWVQEELDRVVGRGRLPEM
ADQPALLRVMATVHEVLRWHPPLPLATPHRAMADDVYAGFTIPAGSIVLGNSWAILHDDK
TYTNPHTFDPRRFVGPNAQPFPEVVFGHGRRECPGRHFALDILFLAVAHVLSVFAIERVD
NSDPGIGDIQGLFTPHVLSYPKPFKASFKPRFPGVESLVRTAALSEI
CYP5144A7 Phanerochaete chrysosporium
JGI gene model pc.24.11.1
This is hybrid with genewise2nd.24.9.1|whiterot1 in second half
(GENE IS SPLIT IN GENOME VIEWER)
MSRFLYDYSTLLYLCAGITFVVLITLSSRPRRRYPPGPKGLPIVGNLFDVPTDHGWKRYQ
EIGKEYGSDIVHFQVFGSHIVVVNTAKAARELLDKRSNIYSDKQRSVMIHELTGWHRNFS
LMPYGEGWRTRRRLFHQHFRPMAVPQYHTRQLKAVHGLVQSLFEAPQNYKEHIRFMAGSA
ILDIIFAFDIQPGDPRIEIVEKGVQTATEFMCSGVYL (1)
VDVFPI (1)
LKYLPSWFPGAGFKRQAAKWKALVDDMHEIPYYQFKQTMREGKAKPCFASTLLSSAAEND
KDSLESLDEIFMSLTGTAYVAGSDTTISALNTFVLAMTMFPETQAAAQEELDRVLGRKRL
PDFDDRDSMPYLTAMVYELLRWHSVLPLGLPHRTLADDEYNGYFIPAGTVIVGNCWGMLH
DDDLFPDPDIFRPERFLNADGTLNSDAHFPIETFGFGRRICPGRYFAQDLLWLTIANVLA
ACSIERVVDEKGFEVRPTGDMTPRVLSMPEPFECNIRPRFSGAEALVRSACLND
CYP5144A8 Phanerochaete chrysosporium
JGI gene model genewise2nd.24.9.1 = Scaffold_205i
fgenesh1_pg.C_scaffold_1000787 [Phchr1:787]
revised at micro exon 8/15/2007
AND AT QQTVMIHEL
MEALASRITVYLCAGVVLVYVFSRVFKRRPHYPPGPRGLPIIGNLLDVPSLYGWIAYKNL
GDQCGSDIVHLEVLGSHYVVLNSAKAARDLLDKRSNNYSDR (2)
QQTVMIHEL (2)
TGLERGLGMLPYGDYWRLHRRLTQQHFRAAAVPQYHARQAKVVRKLLHSLLDSPERFMDH
IRFMAGAIILDIVYALDVHPGDHMIEVVETAMGRINEIINAGVFL (1)
VDVIPV (1)
LKYLPSWFPGAGFKRRAAAWKVDIAPMFEAPYERFKQSLGGTTRPSFAGNLLSRVQNEEE
LSQLEDVFMNITGTAYGAGSDTTLATLTGFVLAMTIFPEKQLAAHAELDKVLERKRLPEV
EDMQYLPSITALVYEVLRWNPAAPLGIPHQTIVDDEYNGYFIPAGTVVIGNAWAMLRDPN
TYPDPDTFKPERFLAKDGSLRDDVPYPTEAFGHGRRICVGRHFAQDVLWIAIAHILTVFR
IERAVDEDGREIVPVPDYTPHFVTMPKPFKCRFTPRFPGAEGLIRSAADASNE
CYP5144A9 Phanerochaete chrysosporium
JGI gene model pc.83.7.1 revised at micro exon 8/15/2007,
revised at RQSTMMLDEL and EFTARIVS 8/16/2007, EST = DV758101.1
MAVLLAAGYYILSVAVFILLYNASRRRQRLPPGPKGLPLIGNLFDVPNDYAWLRYKELGQ
QYGSDIVHMQALGNHILVLNSMKAAVEILDKRADISSDRQSTMMLDEL
SGLGRAWTQLGHNDSWRIHRRLFHQHFRPSAISQYHTKQTKAIHRMLSFLRESPAQYMDH
IRFMAGSMILDVVYTLDVQPGDYRIKLAEMVAHVSTEVFTAGVWM (1)
VDMIPM (1)
LRHLPTWFPGAGFKIQAAKWKTTVDRSYDIPYEQFKASMHEGGGEPCLASALLSSAEDVE
ELERMDKVFSSLTGTAYIAGTDTTVSTLASFVLAMTIFPEAQLAAQAEIDRVLGGTRLPD
INDKANLPQVTAILYETLRWNPVLPLALPHRTTADTSYDGYYIPAGTVVLGNSWAILQDE
TLFPEPQLFKPERYLNGDGSLNSSAHYPIETFGFGRRICPGRYFAQDAVWLAIAHILAVF
KIERARDGDGKEIVPTPEFTARIVS (2)
MPKPFECKFKVRSPQAESLIESAALGG
CYP5144A10 Phanerochaete chrysosporium
JGI gene model pc.83.8.1 revised at micro exons 8/16/2007
MALLVYFCAGLVPVLLLVLGLRKRPRYPPGPRGVPIFGNIFDVPMKYAWLEYVKYGQQYKSDIVHFQVLGQHIVVLNSLQAVGDLLDKQSSIYSDR (2)
VPSVMLNEL (2)
TGWSRSWVQMEYGDQWRMHRRLMHQHFRSTMIPQYHPKQTKAVRRLIQSLLEQPEHFMEHVHFLSGSLILDVVFSFDVRPGDAILALAERAVDTTKAIIAAGVWL (1)
VDVVPI (1)
LKYIPSWFPGAGFKRIAAKWKTDVNKMFDVPYAKFKDSMREGSATPCFASALLSGAEDDNGGVIDNQDEVFISLTGTAYVAGSDTLSDALSTFLLAMIAFPEKQRAAHEALDCVLERKRLPGVEDRDALPHITALAYEVLRWHPVVPLSIPHRTTADSYYKGYYIPAGSTIFPNSWAILHDEALYPEPHLFRPERFLNEDGSLHAHARDPIEAFGYGRRICPGRHFAHDALWLAIAHILAVFKIERALDVDGNEIEPKLDFMPHFLSMPKPFKCRFTPRFPDAANLALSASSDY
CYP5144A11 Phanerochaete chrysosporium
JGI gene model ug.83.30.1 revised at micro exons
and after EXXR motif 8/16/2007
GC boundary at HIRY, added C-term
MGWTLCLYALLGLTGLWVAARVRRPRQRYPPGPTGLPVLGNVFDVPLENGWLVFDQWARQYDSDVVHAEALGRHIYVVNSAKAARELFDGRPHVYSDK (2)
DQSVMLLEL (2)
SGWWRSWVMLPYGDYWKEHRRLFHQHFRPQSLPQYHEKQAKAARRLVRLLLDSPQDYAKHIRY (2)
ATGSSILNVVYSFDAQPGDPRLELVEAAMGTANELMHTGVYL (1)
VDIFPV (1)
LKHLPMWFPGAHFKRQAARYKRLVDDMFEIPYAQLKSSMQEGTIEPCFAAALLSEAEDSASPERDDMFMNLAGTAYAAGTDTIMMTLLTFILAMVLHPEEQAAVQEEIDRVVGRDRLPGLADRESLPRVTAVIQEVLRWHPPLPLA
TPHRAASDDEYNGYHIPAGALVLGNCWAMLHDARVYPDPDVFRPGRFLAAGGDAPRADVPLPAEAFGFGRRICPGRHFALDSLFLFVAHLLAAFRIEHAVDAEGNVVPVVAAFEPQAFR (2)
SPPKPFKARFTLRYCGAENLVRGGVRAG*
CYP5144A12 Phanerochaete chrysosporium
JGI gene model pc.16.82.1 revised at micro exon
fgenesh1_pg.C_scaffold_8000230 [Phchr1:5055],
and added one exon before it. 8/15/2007
added N-term 8/16/2007
added RTHSVMLNELSGWAE and WYTPFPLG and C-term exon 8/16/2007
MELWFDFPSVVTYVLAA
VSCASLLILHTRRRPRYPPGPKGLPIVGNLLDVPTHNAWIKYKQLGKKYGSDIIHFEVFG
SHIVVLNSTTVARDILEKRSQISSD
RTHSVMLNELSGWAE
ERNFGFMRYGDGWRRQRRLFQQHFRRKAVTQYHAIQSKSVHSLLNALLDRPERFIANLRF (2)
MAGSMILRIVYGTDIQPGDSRLTLVEKAVGTLVEVMNAGVFL (1)
VDVFPI (1)
LKHIPSWMPGAGFKRKAAEWKVLVDDMYEVPYNVGTLSIFFLAMTIFPSVQVAAQEEIDR
VLGRKRLPSIEDRNALPRTTAIVYEVLRWYTPFPLGVPHRTIADDEYNGYFIPAGTTIIA
NAWYAMLHDEERYPNLETFIPERFLNKDGSLRSDACIPLEPFGFGRRICPGRYFAEDIVW
LAIASILSVFRVEPPVDEHGEPLKQTATFGTRFLS (2)
PAPFKCCFTLRYPEAEGLIRASATSTA*
CYP5144A13 Phanerochaete chrysosporium
JGI gene model pc.16.83.1 = GX.16.34.1 (USE THIS MODEL)
= SCAFFOLD 4e
fgenesh1_pg.C_scaffold_8000229 [Phchr1:5054] ver2,
ESTs = DV761651.1, DV753979.1
revised at micro exon 8/15/2007,
revised at AHSIMLNELS and C-term 8/16/2007
REVISED SEQ = 50% TO CYP5144A8, IT SITS NEXT TO 5144A12
MTTLALASSLTYLFAGVLLVCLFVSYARKRPRYPPGPKGLPLIRNLLDIPADYPWITYRD
LAEKYNSDILHFEVFGSHLVVLNSAEATRQILEKQSSITSDRAHSIMLNELSGWDTDRTV
TFMEYGESWRRHRKLFQEHFRQQAIPRYHHAQTKGVNRLLKSLLDTPEKFSAHIRFMSAY
TITEVVFGKEVGPDDPSIEVVDDGMHTLNELLNAGVFL (1)
VDIFPL (1)
LRYVPSWFPGASFKRLAGKWKKAVDDMYTIPYNNYKATLGEGDANTCLLATAMADKVD
QDDARVVDHDLMCLAGTTFGAGYDTTATALGIFIMVMAVHPEAQISIHEELDRVLHRDRL
PTMEDRKELPRTTALMYETFRWHLPLPLG
VPHQTTAAIHYNGYFIPQGANIVANSWAILRDEGLYPDPETFKPERWLDADGSLRDDMRF
PVEMFGYGRRICVGRHFAEDIVWLAIASILSVYKIEPPVDENGTVRALEADFTPRLFSAP
KPFKCRFTPRFPGAEGLIRASL*
CYP5144A14P Phanerochaete chrysosporium
JGI gene model pc.24.16.1 = gx.24.13.1
PSEUDOGENE MISSING C-TERM
revised at micro exons 8/16/2007
MPDCTTIGYLLASVALAYALASRHPRSSRYPPGPRGLPLLGNLFDMPRKHSWTKHQELSK
TYESDVIHYQVLGLHIMALNSGEAVRDLLNKRSTIYSDR (2)
QETVMLHEL (2)
TGWHRNWALMRYGDAWKERRRHFHEHFRPQAVSQYNFKQVKAARILLNSLLESPRAFSEH
IRFMASSLILDIVYALDVRPDDPEARRVERALETLAEISASVFM (1)
VDLIPV (1)
LKYLPSWFPGAGSKRQASIWKNIVDEMFETAYQVCKNSAQHEYVRPCFTTALLSEVSDPA
NMKEMDEIFMSLAGTTYI (1)
GGSDT (0)
CYP5144A15P Phanerochaete chrysosporium
JGI gene model pc.24.17.1 PSEUDOGENE
64% TO 5144A1
IT APPEARS THAT 5144A14P AND 5144A15P WERE PARTS OF A SINGLE
GENE DISRUPTED BY A TRANSPOSON CONTAINING A RETROVIRUS-
RELATED POL POLYPROTEIN THAT NOW LIES BETWEEN THEM
AQSAARSSTASTEQINATLNTWMLAMTLFPDTQVAVQDELDMVLGRKHLPSIEDRDSLPR
VTAMLHEVLRWHPVGPMGVPHRLTVDDEYRGYHIPAGTIVMINAWAILHDESVYPEPDIF
RPERYLDSDGRLRTDMPYPVEGFGAGRRLCPGRHFAHDMLWLAIAHVLTVFRIERAVDED
GREIVPEAKFEPWLIRCASLCVGVPCTAHLAVSPPEPFQCQTKLRFPEAEGLVHLAAMDE
CYP5144A16 Phanerochaete chrysosporium
JGI gene model e_gww2.1.906.1 [Phchr1:132380]
NEW SEQ 2588519-2588442 REGION (-) STRAND SCAF_1
68% TO 5144A5 AA 311-336
MEGIPILSYVTLGLVTVWTILSLRKPRRRYPPGPKGLPVLGNV
FDIPLENGWLIFDKWARQY (1)
GSDIVHVEALGKHIYVINSAKVAREIFDGRPHNYSDK (2)
EQSTMLLEL (2)
SGWGRSWVMFPYGDYWRQHRRLFHQHFRAQSIPQYHQKQAAAA
RRLLQLLLDTPADFAKHIRY (2)
ATGSSIVDVVYSFDTPPGDPRLEIVEAAMGTASELLHSGIYL (1)
VDVFPI (1)
LKYVPAGFPGAQFKRKAAHYNKLVKDMFTIPYTQVKTAM
KEGSVQPCFTTALLSESDDLDTPERDKIFQSLVGTAYAAGTDTLMISMLTFMLAMVLHPE
AQTAAQNEIDSVVGRDRLPGMTDRDSLPRVTALIQEVLRWHCPMPLATPHRAIVNDEYNG
YHIAAGSVVIGNAWAMLHDEDVYPDPHSFKPDRFLTTDGRLRDDIPFPIEAFGFGRRICP
GRYFAMDALFLFVSHVLAVFRIEHSVDAHGNVVGVEAEFQPQGFRCA*
CYP5144A17P Phanerochaete chrysosporium
JGI gene model gx.24.12.1 PSEUDOGENE
49% to CYP5144A15P, 57% TO 5144A5
scaffold_1:2496394-2495844 (-) strand
2496394 IADREPLPPVTA 2496356
2496230 HTPRYERRHSGYYMSAGLLVIGDTWY (0) 2496153
2496068 RFLMAERALRTDVTFPIEVFGYSRRICLGRQFAKDVLFLAISNILAIFTI
EKAVDEHSGSIEVQNAFLPHAIRCA 2495844
CYP5144A18 Phanerochaete chrysosporium
JGI gene model fgenesh1_pg.C_scaffold_1000782 [Phchr1:782]
same as Scaffold_205c gene model complete,
revised at micro exons VDLIPI (1)
and PQTVMLHEL 8/16/2007, 62% to 5144A1
GC boundary at PGLIR
MESLTLRNCASAFLAG
LLVLACGLVLRPRRRPRYPPGPKGLPLVGNMLDIPTEYAWERYYELGKEY
GSDVLFFRVLGSHFLVLNSAAAANELLEKRANVYSDR (2)
PQTVMLHEL (2)
TGWDQNWAFWEYGEGWKQARKMFHQHFRPSAAPQYHLKQ
TKAARRFVKLLLESPASFAQHAR
FLAGSAILDAVYAFDVQADDPRIALVERGVHTLVEISRGVFL
VDLIPI (1)
LKYIPSWFPGAGFKRQAAQWKDAVDATYSDPYRQFKTLL
RNGQAEPCVAASLLSSSGDEPSGALDDLLKSVAGTAYV
GGSDT
VSATLTTFILAMTMFPDAQAAAHAQLDEVLKRTRLPEMADRAALPYITAILYEVLR
WQPAGPL
GLPRRLMADDEYRGWHIPAGTVVLPNIW
AMSHDPGTHAVPAQFVPARYLAADGTLREDVPCPADVFGFGRRVCPGRPFAQDVLWLAI
AHVLSVFRMEGPMGERGEIRHSRLFTPGLIR (2)
LPEPFACSFRPRFPGAENLVDAGVVG*
CYP5144B1 Phanerochaete chrysosporium
JGI gene models pc.23.12.1 and
e_gww2.8.230.1 [Phchr1:138753]
revised at micro exon AND PHAPIVSTIL 8/16/2007
MLDTTPFTLALLTVGAVCLLGLIKGASRRRRLPPGPKGVPLLGNIFDAPKEHEWRTFKEW
GRTYESDVVHFGILGTHYVVLNSAWAALDLMDKRSHNYSDN (2)
PHAPIVSTIL (2)
TGWDRNWGFMKYGDYWRAHRRMFHQHFRPNAVSAYHSTSQQAVRELLRLLYAKPEHFKEH
IQHMTGYNIIKLMFGVAVSPEDDPILARMENALRILGKIANPGVYL (1)
VDSFPL (1)
LRFIPSWVPGAKFKRDAEAWKPVIDKTYTQVYEEIKTSYANGSPVPCLVTEMLEDVLKVD
NEAYRDMLEDVIINGGGTAYVAAYDTSSSVLSTFVLAMLLYPDVQRTAQEELDQIVGPDR
LPTMEDQPSLPYVTALATEVLRWRPALPIGVAHKSVVDDEYRGYHIPGGSVIIPNVQAIL
HDEGSFPDPDTFNPRRFLDSEGQQLEELTGIVSAAFGFGRRICPGRYFAKDVVWLTIASV
LSTFNIEKHFNEAGNAVEPSGEYTPGIISYPAPFKAAFKPRSESAVELVR
CYP5144C1 Phanerochaete chrysosporium
JGI gene models ug.83.31.1 revised at micro exons 8/16/2007
fgenesh1_pg.C_scaffold_1000766 [Phchr1:766]
MFSALVLSLLLAAALFLRFRRKRYPLPPGPKGLPIIGNARDIPKSFPWYTYDRWSREYNS
EIIYLRLVGTDVIVINSEKAANELLNKRSTIYSDR (2)
EHMTMLLDL (2)
VGWGGRNFAFAHYGDLWRAHRRLFHQYFHPGAVPAYHAKSTLEVRRLLPRLLSHPDDFMQ
SIRTMTGAIILGITFGMELQPENDPFVALAEEALHAMAQVGNVGSYI (1)
VDYLPW (1)
LQYLPSWAPGAAFKRQAAKWNKIVLEMYEKPFQTIKQALARGEAPPSILTSMLETLDPEE
DNAARESDMRHVTGTAYTAGADTTVSSLGTFILAMLLHPEVQRRAQEEIDRVVGSDRFPE
YDDRDSLPYITAIMKETLRWRQVTPLAVPHRLRVDDEYNGYHLPAGSVVVGNSWAMLHDE
ERYPNSDLFDPTRFLTPDGELDPDAPGPELAAFGFGRRICPGRYFAMDSMWIAMAHILAT
VNIEKAVDDAGNILEPSGEYTYPVPFKVAFKPRSAAADALIQGGTPLA
CYP5144C2 Phanerochaete chrysosporium
JGI gene models pc.83.19.1 revised at micro exon 8/15/2007
fgenesh1_pg.C_scaffold_1000761 [Phchr1:761]
REVISED EXXR REGION AND PSHTLLVTV, and E*LTYAKWSREC (1)
Added C-term
8/16/2007 Note: there is a stop codon in a conserved region,
possible pseudogene
MDIPVPYAFIVVGALVLFFRLRKKPRFPPGPKGLPIVGNALDLPKAR
E*LTYAKWSREC (1)
GSDIIHLRFFGTHVFVLNSVKVVNELMVKRSAIYSDR (2)
PSHTLLVTV (2)
TGWQRNFTFVDLGDHWKARARMFQQNLGTSTISKHRPKLIEGNRKLLLNLLLSPDDFMKH
IRYLSGSSILGIIYGIEVQQDHDPFVETAEKALQCLAAVINAGSYA (1)
VNYVPI (1)
LRFLPTWAPGAQFKRDAAEWYKYVTALIDGPYTYVKESLANGENNTSIVGTLLQELSDDE
KRSEQEDTIREAFGTAYTGGVDTTYSSVNSFILAMLKYPDVQRKAQEELDRVIGRDRLPS
FDDRDALPYITAIVKETLRWGLVAPLAAPHQLRVDDEYEGYFLPAGSVIIGNAWAILNDE
KRYPHPESFIPERYLTTDGTLDSSAPDPMEACFGFGRRMCLGRYFAFDSLWIAVASLAAA
FHMEKAVDESGLVIEPSGEYTSGTAC (2)
YPLPFKAVFRPRHEGVVALIKADVSESDSL*
CYP5144C3 Phanerochaete chrysosporium
JGI gene models pc.20.52.1 revised at micro exons 8/16/2007
MDDIVLVLLVACAVALYARTKRTRYRLPPGPKGLPILGNTYDIPAKYEWLAYEKWSRDFG
SDIICLKFVGTPVIVLNSIQAINDLLEKRSSIYSDR (2)
PVTVMAYEM (2)
VGLDRNFGFVPYGDVWREHRHLFHQYFRLDMVPKYHDRMLKHSKDLLQRLLVSPDRLMEH
LRFSVAGASILNISYGIDVQPENDHYIAVADEAIHALAVTGNAGSYL (1)
VDYLPL (1)
LRYIPAWVPGAKFKRDAANWWEKTRLMIDEPFNYAKQRMAQGKGMDCVTAVMLSAIGEDQ
DREHQELLIKQVLSVSYIGGADTTVSALATFVLAMMQNPKMQRIAQADIDRVVGGERLPS
VEDRDSLPYVTAIVKEALRWRPVIPLAVPHRVTVDDEYKGYHIPAGSIIVGNVWAVLHDE
TRYPNPDVFDPTRFLTSDGQLDNNAPDPAEACFGFGRRICAGRYFALDAVWLSVACILAT
FDIAKPLDENGNPIEPSGEYTTGLLSHPVPFKVSFKPRSAAAEALVREPISRDL
CYP5144C4 Phanerochaete chrysosporium
JGI gene models gx.20.26.1 revised at micro exons 8/16/2007
MDYLGISILLVAALALHYFLRKKRYRLPPGPKGLPILGNALDIPAKHEWLAYAKWGQECG
SDIIYLNLAGTPVVVLNSAKAAKDLLEKRSSIYSDR (2)
PVTVMAHEL (2)
IGLGRNFGLKPYGDTWREHRRLVHQHFRTENVPRYHEFTSKQIGRLLLHLLEDPSNFVRH
LRIMAGASILRICYGIDVQPDNDHYLSVADEAIESIAATGNAGSYL (1)
VDSLPI (1)
LRYLPSWAPGAQFKRDAAKWKEKVDRMIAEPFDYAKRYMASTEGAATDYIAGLLLSAMDP
GRDKTQQEIAIRDSLWAAYVGGADTSVSALATFTLAMVLYPDVQQTAQAELDRVLGKDTL
PTIEDRDSLPYVTAVVKETLRWHPVTPLAVPHKVTTDDEYRGYHIPARSIVVGNVWAILH
DPDRYPNPESFEPSRYLTSDGLLDPAAPDPTEACFGFGRRICPGRHLAYDTIWTGIASIL
SSFDISPPLDEQGKPVNPSEEYTTGMLSHPVPFRANFKARSENVEALIRRITLCE
CYP5144C5 Phanerochaete chrysosporium
JGI gene model pc.20.54.1 revised at micro exon 8/15/2007
and EIMVMCHEM
MQTVVLAILFVFAIALPIYSRRKRYRLPPGPRGLPIIGNILDIPAGREWLTYAKWSREYG
SDIIYLNMAGTPVYVLNSIQATTDLLEKRSSTYSDR (2)
EIMVMCHEI (2)
VGWGKNFAFQPYGDFWREHRRMFHQHFHPEAVTKHHVHILKQAKDLLQRLLVDPDDFMQH
LRFMAGAAILRVSYGINVQPENDHYIGIAERAIHSLALTGNAGSYL (1)
VDNLPI (1)
LKYLPSWAPGARFKRDGEIWRREVDQMFSEPFELVKRQMVGADGEPPDCVTASLLTTLDE
RKDRPREELEIAVKQAVGTSYVGGADTTVSSVATFILAMLQFPDVQRTAQAEIDRVVGST
RLPTIEERGSLPYVTAVMKETLRWNQVTPLAVPHKVTVDDEYKGYFIQAGSIVIGNSWAV
LHDETRYPNPEAFDPTRFLTPDGKLNPSAPDPVEAAFGFGRRICPGRHFAMDAIWMNLAF
ILATFNIEKPLDEAGRPIEPSGLYTPGLLSHPEPFRVKFIPRSKAAEALIRETMFYD
CYP5144C6 Phanerochaete chrysosporium
JGI gene model pc.20.55.1 revised at micro exon 8/16/2007
and VVTTMAHEM
MENITFAVLFVLLLAVPLFFKRQRYRFPPGPKSLPLIGSVLEFPVQSSWLTYQRWGRELA
SDIIYLNVLGKHIYVLNSAQAVSDLLEKRSGTYSDR (2)
VVTTMAHEM (2)
VGWDKNFALQPYGEFWREHRKAFHQQFQPDMVPRYHVHMYKQAKDLVRRLIAEPNALKQH
LRYMAGALILRVSYGIDAEPNDDHYFEIIEQAVYSLTEVANTGAYL (1)
VDFLPF (1)
VKYVPSWMPGAQFKRDATEWAPQVNQMFDEPFDVVKRALAEGNAPDSVCAALLSELDPRK
DRAHQETVIKQAVGTAYIGGADTTVSTLSTFVLAMMTHPDVQRTAQEHIDRVTGGDRLPT
IEDRDALSYVTAIIKEALRWRPVLPMAVPHITTADDEYRGYHIPKGSIVMGNAWAVLHDE
ARYANPDAFDPTRFLTPAGTLDKDAPDALEAAFGYGRRVCAGLHFALDSMWVNVACVLAT
LDIRKPVDEHGVPVEPSMAYTTGLLEQPEPFAVVFKPRSQAAEALIYEGHDD
CYP5144C7 Phanerochaete chrysosporium
JGI gene models pc.142.5.1 , e_gww2.9.179.1
revised at micro exon 8/15/2007
revised at RLHSTMLHDY 8/16/2007, ESTs = DV760024.1, DV759090.1
revised region after EVLR WRPVAPL
MDTLLLAGLVAVAVVAAGCLAHSRRQRFPPGPKGLPLLQNLLDVPRHRPQWEAYRDWGLK
YNSDIVHLRLFGVSFVIVNTADAVTELFSRRSSVYSDR (2)
LHSTMLHDY (2)
IGWEKAIVMKNYGEDWREHSRLFHQSFQPKVIQEYYPRLYEEARKLLPRLLKGDDFVASL
RVMTASAILGVTFGMEINDSNDPYVTIADRAIQSLVEAGMPGSYM (1)
VEYIPL (1)
MRYIPSWAPGGKFKRDAAEWRTLVSDMFTKPFEHIKSAIRHGVARPSIATSLLMGLDDKQ
DNARREHVIRNVTGTAYVGAADTTVAALRTFILAMVMHPAIQKAAQAELDRVVGRDCLPT
FADREHLPYLTAIQYEVLR (2)
WRPVAPL (1)
GFPRRANADDEYHGYHIPKDAIVLGNIWAILHDPARYRDPAAFDPARWLTPDGALRADAG
DAMLAFGFGRRICPGRHYAVANMWINMAYMLAAFDIAPPRDAAGRAVPPAGEHTTGLLTY
PKPFGAVFTPRSAAALRLIVADADD
CYP5144C8 Phanerochaete chrysosporium
JGI gene models genewise.35.22.1 = GX.35.9.1
revised at micro exons 8/16/2007
e_gww2.4.188.1
MGVLILCAIAILAALLCYHHFRARRFRLPPGPKGLPIVGNVLDVPKDGPGWLTYERWSHE
YGSDVIYLNLLGSSIVILNSSKATTDLLDKRSPIYSDR (2)
QRLTVLHDF (2)
VKGDRAFAFLGYGDEWRQHRGIFHKYFHGQAVHNFRPKMLEEARKVLVRLQSTDDYDRCF
RVMSAASILGVTFGMDIEDINDPYVVLAEEAINYVLSAAIPGSFV (1)
VDSLPL (1)
LKYLPAWAPGAGFKCKGAEWHDLVSRMILTPFETLKQKMAEGTAKPCIATAIVQKLEESK
GGDAQRETQIAQYVTGTAYTAAADTTVSSLCTFILAMVLNPEVQALAQEEIDRVIGTTSL
PDYTYRDSLPYVSAIMYEVLRWRPVAPLGVPHRLMEDDEYEGYHIPGGSLVVGNIWAITH
DPVRYLNPDAFDPTRWLTTDGQLGDVTDALVAFGFGRRVCPGRHYALEALWITLVHVLAA
YRIEPPVDAHGRARPPSGEYLPGFIAFPAPFKAVFKPRSPVALGLIQTALG
CYP5144D1 Phanerochaete chrysosporium
JGI gene models pc.24.13.1 and genewise2nd.24.10.1
revised at micro exons 8/16/2007
MLDRSVLLPCLVGIVAAIIIVSRRGRERYRFPPGPKPLPLIGNLLDAPTDLGWYTYAKWA
RQYHSDIIHFEVFGQHFYILNSVRVAKDLLERRSQVYADR (2)
QQSVMVQEL (2)
TGWHRVFSMKAYGESWRQQRRLFHQHFRQQAIPEYHAELTNGARMLLRSFLESPNHFLEH
IRHISGGTILAVLYGIDVDNYSAERMESIEKAIEIVTEIADGGVYL (1)
VDFIPL (1)
LKYLPTWFPGAGFKRRAAEWRVHVETMFEAPYGDVKRDMKLGKAKPCVATKLMSAFGDKA
EDPEIEELLICVTGTAYAASDTIVFAMIAFVRAMMVFPEVQCKAQQELDRVVGRDRLPVI
SDQASLPYLAAVTKELLRWHPITPIAVPHKSTTDDWYDGYYVAAGSIVIANVWAMFRDEE
RYPDPEAFRPERFLTAEGTLDPAVPDPVEVFGFGRRMCAGRHYVDAALFLAIAHVLHALT
IEKPRDARIPVVDPPPGYALSRLFWAPEPFEADIKPRFEGVERLMQMSSLHSF
CYP5144D2 Phanerochaete chrysosporium
JGI gene model pc.24.14.1
revised at micro exon 8/15/2007 and at QLSVMACEL
MLSSTILVFSSVCTLAAIVAIVRRFGGKRRHHFPPGPKGLPIVGNLFDVPTNFGWYTFAK
WAQQYNSDIIHFEVLGKHFYVLHSAALAKELFERRSQTYSDR (2)
QLSVMACEL (2)
TGWHRVLTLTPYGEYWRQYRRLFHEHFRAQVIPQYEDKMLTSARNLLRLLLETPDRFLRH
IRHASGRTMLDIVYALDTEAHNNAVILESVEKAIEIFAEVAEGGAYL (1)
VDHIPI (1)
LKYLPAWFPGASFKRQAAAWRVHVDTMYEAPYQDVNRRLLAGKAKPCITTSLISAFSDKC
EDPDVEESLISFAGTTYAGSDTSVFKMTIFMRAMLLFPEVQVKAQEELDRVVGRDRLPEL
ADKDSLPYISALYKELLRWHPLFPLAFPHKSTVDDWLDGYFIPAGSLIIGNAWATLHDEE
RYPDPEAFRPERFLSDDGKLDPSVPDPVEAFGYGRRICPGRHYADASLFLYIAHILFAFT
IRKPLDERGNVIEPPPGVPEPFKASIKPRFEGVEELIQLSTQLATSD
CYP5144D3 Phanerochaete chrysosporium
JGI gene models pc.24.18.1
e_gww2.1.419.1 [Phchr1:133291] ver2
revised at micro exons 8/16/2007
MFDNGVTIALLLIGVTLLVAEALKKRHRFPPGPKGLPIIGNLLDVPKDYHWLTYTAWSRQFDSDIIHLEALGQHYFVISSVDVAKDIFEGRSQLYSDR (2)
PQTVMLHEL (2)
TGWERNFAMMAYGDSWRRHRRLFHQHFRLQNVPAYHDQIAKGARNLAQLLLQTPDKFGRHIRHVVGAVILDIMYGIEVAPDDDERMEHLERAVHIFMELGQAGGFL (1)
VDFIPA (1)
LKYLPTWFPGAAFKRQAMEWKPQVDAMYEISYNEVKDSMQRDQAKPCITSALLTACWDDLDQSNMEETLIGVTGTGYAGSDTSVFALNAFVLAMMLFPDVQRKAQEELDRVVGRERLPSADDRDSLPYISAVIKELLRWHPITPTAAPHKSIADDYYNGYFIPAGSIVIGNTWAMLHNEERYPDPEAFKPERFLTPEGTLDPHVPDPAEGFGFGRRICPGRHFAQASLFLNISNVLATCMIEKPVDEFGNVVEPTRECTSRFFWALKPFEAKITPRFEGVENLVQTMSTYTN
CYP5144D4 Phanerochaete chrysosporium
JGI gene models e_gww2.1.429.1 [Phchr1:132914]
Scaffold_252d seq next to CYP5144D5
55% to CYP5144D5
revised at HETVMARDL 8/16.2007, added C-term
MQSNALVIACLVAGLLAVARASRKSRQRRYPPGPNGLPILKNLFDIPRTYSWLTYEAWGREYNSDVV
HFEALGLHFVVLNSTEAAKELLEGRSHIYSDR (2)
HETVMARDL (2)
TGWHRHWGIMAYGDAWRQRRRLFHQHFRP
QAVPQYHEPMVRSARTLLQLLLESPDDWMRHVHHVSGGTVLKVLYAVDVDPHDDEGMDVV
DKALQIFMKLPEPFV (1)
VNFIPP (1)
LKHLPAWFPGAGFKRRAMEWKVHVDRMFEEPYHKIKVAAVTRPCIATSLLSAAWEDLEN
PDVEEQLISVLGTAY
GEYNLALEQTIFSVYSFVIAMMLYPDVQRKAQEELDQVVGRDRLPEIADRESLPY
FSAVLKEVFRWHPVTPIAAPHKSLEDDWYKGYFIPAGTIVFGNTWAILHEESRYAEPDVL
RPERFLTPAGTLDPAVPDPDEVFGYGRRICPGRYFVQDALFLYASHLLAAFTLSKFVDDEGHVEEP (2)
RLTCIFVTLRIPRAFKANIKPRYEGAERLVQMAFTSAS*
CYP5144D5 Phanerochaete chrysosporium
JGI gene models GX.24.18.1
temp name PFF_252c revised at micro exon 8/15/2007
revised at HKTVMLHEL 8/16.2007, EST = DV762757.1
MSDSTLLAVGLIFGLLVLARVSRKRPRFPPGPKGLPIVGNLFGIPRDHSWLTYAEWGRLY
ISNIVHFEALGQHFFVLNDEKITKEIFEGRSQIYSDR
HKTVMLHEL
TGWHRNWAFTPYGESWRQNRRLFHQFFRAQAIPDYHDHMAKGARGLVQLLLQTPENWMRH
IRHASGSTVLDAVYAMDVDPNDNERLEGVERAVETLVEIAEAGGYL (1)
VDFIPA (1)
LKHIPTWFPGAGFKRQAMAWKRDIDALFERPYHEVKSAMGCRIFSEQRGKARSCVTSSLM
SMFSEKLGDPDVEETIMGIAGTSY (1)
AGSDTTVFTMFAFVQAMLLYPNVQRKAQEELDRVVGRDRLPEVADRQSLPYVSAIVKEIL
RWNPILPAAVYHKSLADDWYEGYFIPAGSIVIGNTWAVLNDAERYPDPEPFKPERFLTAD
GQLDSQVPDPVEVFGYGRRVCAGRHFAQTALFLYIAHVLALFTIDNPLDESGHVIKPRRD
CLTRLVPKPFKAKFKPRFTGVEELVHMSSIPTQ
CYP5144E1 Phanerochaete chrysosporium
JGI gene models pc.8.2.1 (genewise.8.1.1)
REVISED AT PRMPMLLDL 8/16/2007
fgenesh1_pg.C_scaffold_17000192
ADDED N-TERM AND COMPLETED C-TERM revised seq at EXXR
MGDTLALNGGIVLAVIVACSIALLLFQRRPHLP
LPPGPKRWPVVGNAFRFPKEREWLTFMRWSREFGALXDLLYYEMWGRPFVVINSHRAAVE
LFERKSALYADR (2)
PRMPMLLDL (2)
CGWAWDLAFMPYDETWKLARKLFTQHFRAGAAGRYRDEETRCARELLADILRDDTQLFEH
ARVTFGKLIMSVTYGIDVRSADDKYITNAQKALYAITATGNVGTYLVDSIPLLKYIPEWF
PGAKFQREAREWREAAEAMSQRPVEDVKIAMAEGTARPSVLRSLLEDYGETMSAQEAYAI
LSATGTAYEAAASETTWSATLTVVLAMLLFPEIQERAHAELDRVVGMDRFPVFEDQPSLP
YITAICKE (0)
ALRWRTPLPL (1)
AVMHRVTQDDVYNGCHIPGGATVVLNSWAILFDPDQYPNPEPFAPERFLAPSGELAPDVP
EPTAAFGYGRRACAGTAMALDTLWIVVASLLWAFDIRRAVDEMGNEIDVAGEYTFGVVCY
PAPFRCALRPRSEGIRSLISLPE*
CYP5144F1 Phanerochaete chrysosporium
JGI gene models pc.240.2.1, e_gww2.5.175.1 [Phchr1:131322]
REVISED AT PEMPMLNDL AND MICRO EXON 8/16/2007
MVSAVLQGLAGLVIILLVRWAARQRQDRKQGPHPPGPPGLPLLGNLLDMPDNPSWMTYIR
WSEKYNSDILRLNVLGSNIIIVNSLDAANDLLDKRSAIYSDR (2)
PEMPMLNDL (2)
CGFGWNVAFRRYDDTWRNGRRVFQHELGPQVVKRFRALEEHATHQLLRNLLREPAEFMGH
LRHMSAFEILRIAYGIEVTGREDPYVDTAEHAVGAVVATCSPGSYLVNIMPFLKHIPEWV
PGAKFKQDAKVWRRYVTELRDKPFSVVKERILRGDAPDCAAKSLLESLESGEDTAGYTED
DIKYALGSMYA (1)
GGSDT (0)
TVSALGSFILGTVLDPAIQARAHADLDRVCPGRLPTFDDQPELPYIDAIVKEALRWNPVLP
IDVAHCSIADDVYRGYFIPKGSLVLANSWAILHDEAAYADPLRFHPDRFMAGDALDGRVRE
PDAAFGFGRRICPGRYMAYDAIWIAVACMLAVFRIDKAKDAQGREITPSGEYNVGFAYPKP
FPCDIRPRSSAHEALIRATAEDA
CYP5144G1 Phanerochaete chrysosporium
JGI gene models pc.119.17.1 , gww2.5.320.1 [Phchr1:40563] ver2
revised TVCSISYEL and I-helix region 8/16/2007
MSSLLRVADAVLLCAALTIIYKLCLRQAKPSRLPYPPGPPGYPLIGHLSGPEGPGGRSWV
TFRDWSLQYGSDVIHLNMAGTHLIVLNTLGACSDLLEKRSTIYSDR (2)
TVCSISYEL (2)
CGLGWSFGLQRYGPEWRDGRKCFESQFNAHAVRKYRPALSREVSRFLHNLCTDPVAWEYH
VHHMAGALIMSVGYAIDVQAKDDPYLNAAEHAGECVQKTLVPGAFLVDILPFLKYLPDWF
PGVGFKQKARSWRKSIMYIRDAPYDVTKKRVVSAVVPDCVAKDLMEKMVNNAKDPVYMER
VARSAVGSMYL (1)
AGADT (0)
THSVLSACVLTLVLNPNFLPRAQASIDEVCQGRLPDFSDYEALPHVHAIVREAMRWNPVV
ALNLPHRCTTDDIYEGHLIPAGSIVIANIWAILHDPAVYPDPESCNPMRYLRCSPDGTVT
LDPAVPNPADVAFGFGRRICPGRFMGYQTVWLALARMLAAFDIQCATDADGVPIVPRGEY
DRPKPFECSIKPRSAAHAALVMQDVDAGEL
CYP5144H1 Phanerochaete chrysosporium
JGI gene models ug.119.22.1, gww2.5.193.1
REVISED AT FGFTMLREL, FGF END DOES NOT HAVE AN AG BOUNDARY
POSSIBLE FRAMESHIFT IN THIS REGION MIGHT CREATE PRLTMLREL
COMPARE TO LENTINULA EST EB011290.1 WITH PRMTMLNEL
REVISED MICRO EXON REGION AT I-HELIX
MASTSQTAFNAALGAACLVYLFAKIYWFVAAGRNLHGLKKLPGPRGWPFVGYLKAAERPA
WLTYWRWSDEYDSDVVTFDVLGTTVVILNSLKAATELLEARSAIYSDR (2)
FGFTMLREL (2)
VGFDWNITVSEYGPYWRDSRRAFAHAFHPHAVARYRPAELKATHQFLRDLLNEPEDFHGR
IRYLAGRQILHIAYGLEIRDRADPWITAAEHGVEIAVKCIIPGSYLVDLIPILKYVPEWF
PGAGFKRQARIWKKEVTSIADAPLAAMEACDSLPDDSAAKPLLERMLDSPDDPAYARHVL
RGTLASMYI (1)
AGADT (0)
TTSTLATFFHALSRHPAVLYEAQRAVDRVCAGRLPTFADYDALPYIHALLRECLRWRPVV
PLNFAHRASKEDVYEGYRIPAGALVLANNWAIMHDPAAYTDPEDFNPRRFLRARAGAGAN
GSGADDSLELDPGVRDPGVAAFGFGRRACPGRYMAYESLWIVMASVLTVFDVLPAEGDEG
EVEYTDGFLSTPKPFRCTIRPRSAAHAKLVYLALELDA
CYP5144J1 Phanerochaete chrysosporium
JGI gene models genewise.24.21.1 = scaf252b = pc.24.20.1
= genewise2nd.24.19.1
46% to CYP205b (CYP5144A2), revised at micro exons 8/16/2007
added N-term
MWVVTCTCAAILYMVLVGLRKRHRFPPGPKGLPLIGNVLNAPAGSSAP
MVYQQWSKLFGSNIIHLKIFGTHFFVLNDAKTASDLLEKRSANYSGR (2)
SQTVMLFDL(2)
TGWDRDWGLLDYGDSWKKHRHVHHRYFHPKVLEAYHPRMEKGVQMLLQLLHRSPADFNAHLRF
2537737 MTGHIIISIVYGIETKSADHPYIGLAEEGVKAFSATAVPGRFL (1) 2537865
VDSLPF (1)
2538014 LKHIPAWFPGADFKRQAALWKKDVDAMYETPFNDIKAAI 2538130
RRGETNTSIVGAALAELEGQADTEEAENIIMNVAGTAYPTASDTTIITLEFFILAMLQHP
EVQRRAQADLERVVGNARLPSIHDQALLPYITAIMHETLRWRPPFRTVSLPRKSLHDDEY
EGYHIPAGSIMIANEWAILHDEARYPNPEEFDPSRFLNTDGSIDHTVPEPVEPFGHGRRL
CPGRHFAMDVIWLTIANILHVYSIEKAVDQSGNVVEPSGKCIDGLLSAPEPFQAVFRPRS
DAAIALLRSID
CYP5144K1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5144K1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5144L1 Postia placenta (brown rot basidiomycete fungi)
CYP5144L2 confidential basidiomycete
CYP5144M1 Postia placenta (brown rot basidiomycete fungi)
CYP5144N1 confidential basidiomycete
CYP5144N2 confidential basidiomycete
CYP5144N3P confidential basidiomycete
CYP5144N4P confidential basidiomycete
CYP5144-un1 Phanerochaete chrysosporium
JGI gene models none
temp name PFF_45b pseudogene
PGPQGLPILRSLFHAPAQFQQLAFQDWGHRYIVLNCAQPASDLSDNRSTVYSDKGGWDRN
MGPLAHSAYWREHRRLAPHHFKDHVR
FTTAATPGMYL (1)
VDSFPM (1)
LRHIPAWLPGAQFKRAAARWRSIVEEVFDSGNPEPCLAACLPTSHRDREDTLMLENVVIN
TSGTAYAAASGTTTTTLLAFILTTMLYPDVQKAVRQELDSVVGQGRLPEMADRNALSSIP
ALMKECLRWRPPLPLGVPHRSTAEDERGRRIQVPAGSTAIGNAWXXXXXXXXYSDPEAVK
PWRFFDAAGFGYGRRVCPGRHCLLDFVWLATANVLVVCSIEEPFDGQWDTVEPSEQHTTG
TIIFLAPFEAVFKXXXXAHVECVR
CYP5145A1 Phanerochaete chrysosporium
JGI gene model ug.82.21.1
ESTs = DV765434.1, DV765432.1, DV759462.1, DV757969.1
MFYPPLVAVDVVFALLALYLIVRFLQKDRTLPFPPGPKPLPLIGNLLDMPSTYQWVTFAD
WHDRYGDISSVTVLGQRIVILNSLDAAVELLEKRSAIYSSRPYMRMAGEILLWARTLVLS
TYPGELFRDIRRFLHRYIGSRGQLERVAPFYELIETSTQDFLQRTLADPVRFVEHIRKNA
GAIILNMTYGYKVQEGYDPLVDLVDRAVDGFVAASTPGSYYVDIFPALQWIPSWFPGAGW
KRRAEAWRADTQAMCDVPFEFAKQERLHGDNNSKNFVSDNLASMETAQQEHHLKMAAGSL
YSGGADTTVSAITTFFLAMTLYPEVQKRAQEELDAVIGTDRLPTLDDRERLPYTRALVSE
VLRWNPIGPLGVPHVSTEDDVYRGYFLPKGSMFIANIWCVPPSTYTYSEPLRFKPERYLG
EQPEMDPRCAVFGFGRRICPGACLNLAEASIFAVSAMALAVFDISKAVEDGVEITPKVEY
TTGTISHPQPFKCSIKPRSKKAEELIRG
CYP5145A2 Phanerochaete chrysosporium
JGI gene models pc.82.61.1 and genewise2nd.82.23.1
revised near RYG 8/16/2007
MPSTHITALDIAVAIFALYIIRRLLQRGRTLPLPPGPRPLPLIGNLLDAPSAYHWETFAE
WNTRYGDVSSITILGQRMVILNSLDAAIDLLEKKSSIYSDRPVMPMAGEILLWSQTLVLS
PYPSDRFRDIRRYLHRYVGSRGQLERVAQTHQLIEDETRGFLQQTLRNPLQFIAHIRKTA
GAIILNMGYGYQVKEGHDPLVDLVDRAVNGFVAASTPGSFLVDIIPALRWVPAWFPGAGW
KRKALTWRADTRATCDVPFEFAKQEALRGSTSNNFVSANIQDIENAEQEYHLKMAAASLY
SGGADTTVSAITTFFLAMTLYPEVQKRAQQELDAVLGAGRLPTLDDREQLPYTRALVSEV
FRWNPIGPLGVPHVSTEDDEYRGYFLPKGSIFIANIWYILRDPHTYTEPLRFKPERFLGE
QPEQDPRAAVFGFGRRICPGACNARVA
CYP5145A3 Phanerochaete chrysosporium
JGI gene model pc.11.258.1
scaf5 partial seq
54% to gx.82.23.1 (5145A2)
MQACLLEVFAHFPPVMAVLLVVLLLILTLFVLVTRKSSRHYPPGPRPLPLLGNIHNAPAQ
RQWKTFAAWKSTYGDVISLTIFGQRIVVLNSLESAIDLLEKRSAVYSDRPRMVMVGELLG
WAQQLVFAPYGEHFRNMRKILHKYLGARGQLDKIEPYHEIIEAATAKFLVRALRDDSDFH
LEHNVHMTSGTINLRIGYGHNIAEGDDELVQMMDDALVGFNRAAVPGAFLVDIIPALKWV
PTWCPGTSWKRQAQEWKDLFVRMTEGPYAMAQQQAERGGHDNIVSMSLSEDMSPEDHYDL
KMAVGSLYGGGTDTTVAIILSFILAMTLHPEAQKKAQKEIDALTNGERLPVIRDREELPY
VRALISEVLRWNPLVPLGVPHRAIADDVYRGYFIPEGSTIVVNMWQLAQDPEVYADPEVF
KPERFLGPDSERDIRTFVFGFGRRICPGLNLAEASTFAICARILAVFEIGKVVEDGKRIT
PDFAFRDGAVRFV
CYP5146A1 Phanerochaete chrysosporium
JGI gene models pc.59.8.1 ,
fgenesh1_pg.C_scaffold_1000663 [Phchr1:663]
Phchr1/scaffold_1:2066931-2069520
MDPATVAVAVVCALAVMHVLTRRARTRLPYPPGPPEDPIIGHLRQMPNNDEAAEVWYRWA
KQYGDVMSLNVLGKRLVILSSEEAATELLEKRSSKYADRPRFPIFERIGWKDMVLLMPYG
PYHKTLRKMIQVPFEKDKAFQFRDIQERATSIMLHNFLADPKGIEHHTHCRYVVSIIVEI
VFGHRILSEDDEHLKIADVFVKIQHEASQPSLLDVSPLFAKLPSWFPGAWFVKYIEDTKA
ILSHAIHHPVSIVQEQLASGIAKPSFVADELERLIKAGQLTPQNKYDVSIAAHMIFGGGT
ETTWNTLTTFIACMLLNPEAQRKAQEEIDKVVGHGRLPDFTDRDSLPYVECVVKETMRWH
PVAPVAVPHKATEDDVYRGMYIPKGAIVIANARSITWDERRFHDPHAFKPERFLPRPLGA
GEDFVQGAVYGWGRRICPGRHLAGDMVWIAIARVLAVFDIQKARDADGNAIEPNIEFTTA
VHPKPFPCELRPRSEKAASLIKESYELHSID
CYP5146A2 Phanerochaete chrysosporium
JGI gene models pc.59.23.1(gw.59.18.1)
gww2.1.504.1 [Phchr1:38849]
Phchr1/scaffold_1:2095089-2097090 adjacent to 5146A4
MGFLTALLLVFVLLCVALVRAVRRRRARPPYPPGPPADPLIGHIRIMPSTDNAHEVFHDW
AQQYGDVMSLDVLGTRYVILNSAEAATDLLEKRNSKYADRPTFPMYERVGWKDTLVFLPY
GPYFRKQRKMLQLPLEKERVTDFRHIEEQETCVMLYNILSDPDNTDAFVHRRYTTAVTME
LAYGHRVVSNDDEYLKAADMVIDVLRSVTRPSLLDVSPIFEYLPAWFPGAWFVKCIKEIK
PVVLREIQHPVSVVQQELMAGTAKPSFVSQQLEDLSRENGLSQEDLYTVSMVAHQIFGGS
ETGWHTIMTFIACMLTNPDVQRKGQEELDSVVGRGRLPDFTDRDSLPYIDCIVKETMRWQ
PVVPLSVPHKAMEDDEYRGMHIPKGATIIPNARGITWDERHFHEPRTYKPERFLPRPQGA
GEVFPQGAVFGWGRRLCPGRYLADDVVWLAIARILAVFDIQKAVDADGNVVEPHIEFTTV
LTSHPKPFPCSLRPRSEKAAELVRQAYDMHMANVAV
CYP5146A3 Phanerochaete chrysosporium
JGI gene models pc.59.24.1(ug.59.33.1) gww2.1.413.1 [Phchr1:38101]
Phchr1/scaffold_1:2097942-2100000
MGFLTALLLALVLLCAIWVRAVRRRRGRLPYPPGPPADPLIGHIRIMPSTDVAHEVFHGW
AQQYGDVMSFSVLGTRYVILNSAEAATDLLEKRNSKYADRPTFPMYERVGWKDALVFLPY
GSYFRKQRKMVQLPFEKEKVTDFRHIEEQESCVMLYNIFSDPDNRDAFVHRRYTTGVTME
LTYGHRVVSDEDEYLKAADMIIDVLRSVTRPSLLDVSPLFEKLPAWFPGAWFVKCIKKTK
PVVLREIQRPVSVVQQKLMAGTAKSSFVSQHLEELSREKGLSEEDLYTVSMAAHQVFGGT
ETAWHTIMTFIACMLTNPDVQRKGQEELDRVVGSGRLPDFTDRDSLPYVDCIVKETMRWQ
PVVPLSVPHRAMEDDEYRGMYIPKGATIIPNARGITWDERHFHEPRTFKPERFLPMPQGA
GEVFPQSAVYGWGRRICPGRYFADDMVWLAVARILAVFDIRKAVDADGNVVEPRIEFATV
LSHPKPFPCSLQPRSEKAAELIRQAYEMHMANVEA
CYP5146A4 Phanerochaete chrysosporium
JGI gene models genewise.59.20.1
e_gww2.1.326.1 [Phchr1:133267]
Phchr1/scaffold_1:2102681-2104782
MGPTAFVAILLCAVLLVQAVRRRRTPLPYPPGPPADPLIGHLRIMPDTSTAPEVWHSWSR
KYGDVMSLSILGKRVVILNSEEAVTELFEKRGAKYADRPSYPLYERVGWKDALILLPYGT
YYRKLRKMLQLPFEKDKAPNYRHIQEQEACVLLHNFLRDPSSVESPIHRRYTAAIIIEIA
FGHRVLSDDDEHLKAADMFVEVQHGAGRPSLLDVSPIFEKLPSWFPGAWHVRYIKEKRPM
ILHAIQHPVSVIRQQLVDGTANPSFVSQQLNDLIREGGLTPENQYDLSIVAHMIFGGGSE
TTWNTLTTFIACMLMNPEVQRKGQEELDRVVGRGRLPDFTDRDSLPYIECVMKETMRWHP
VAPLAMPRRAIEDDEYHGMYIPKGAMVIANISLTWDERRFHDARSFKPERFLPKPEGAGE
VLPPSFAFGWGRRICPGRYLADDVVWIAVARILATLDIRKPKAADGSIIEPRIEFEAALT
SHPKPFPCEIRPRSDKAAELIKQAYDMHMASVET
CYP5146B1 Phanerochaete chrysosporium
JGI gene models pc.59.19.1 , e_gww2.1.427.1 [Phchr1:132579]
Phchr1/scaffold_1:2085390-2087317
MLVLLGFVSLVLFLVYRRSVRASRGRLPPGPPADPIIGHMRVFPRANHGEVFHQWSKQYG
DVLHLDVLGKSIIVLNSQEAANDLLDKRSANYSDRPEFPAFNLLGWDSMLVFLRYGPAFL
RQRRLMQQPLTRTGVVVFRPVQLQQCHVLLKNLLASPKDFDAHLRRRFASAITLEMTYGH
KVSSDDDAYLDIADKVNVVLTKMSKAAILDLFPRAKHLPSWFPGAWFIRYANDHRHLIWE
MASKPFEQVEQQLAAGTAQPSFVSMHLEEMHRQNTHDADNVSALKTAAAHMWTGGEETST
LLIFVLAAVRNRDAVRRAQAELDRVLGPGRLPTFEDMDALPYVEAFIKETIRFHSALPLG
IPHRAMADDVYRDMLIPKDATVLVNSTALARDPAAYSTPERFWPERFLPPHSEPPPVGLG
FGWGRRVCPGRHLAEASLWIVVASMLAAFDIAPVQDAHGRDAPPELRFTQAITFSEDSHP
EPFECSITPRSEKVAQLIMQL
CYP5146C1 Phanerochaete chrysosporium
JGI gene models pc.175.6.1 (genewise2nd.175.5.1)
scaffold_6:685560-687500 region MMPYILGVTLLLLTVIVLRVLRARASRAAPYPPGPPAYPVIGSVGPFPAHEPHLGLAELA
KKYGDVMYFEIFGKPLVVLSSLEAASDLLEKRSAIYSSRPRFAVHEMIGWTDMVSFLPYG
EQFNKQRKFFLHTFSKQGCLVFRSSQVAQTHLLLKNILQCPTRYIEYLRRFSTAVIMEIA
YGHKVSSEDDPYVKIAEDTNNVLMAAGHSLALVDFLPWLRHLPAWFPGNWFARVAQESRP
VIQRMRNFPFDQVVQQMASGTASPSFVSMQIEELERDGGASPENLHILKIAASQMYGAGA
ETTWSTIMNVIAFLLLHPTAQRKAQDELDSVLRGERMPDFDDRKSLPYLDALLLEVMRLQ
PTAPLGVPHSSTTDDIYRGMFIPKDSIVLTNTTYALAMDDRVYRNPTEFRPERFLPPHAE
PNPNGIVFGWGRRICPGRYLADTSVWIVMASFLTVFEIVPERDRNGQDIIPEIQWCSAPF
PCVIRPRSEKEVKLVSRL
CYP5147A1 Phanerochaete chrysosporium
JGI gene model ug.50.27.1
MPLLLVDIAALVAGLVLLFMLDSWRRKGQHLPPGPPGLPFLGNILQIPRKKEFIVFRDLG
NIYGDIVTLRVPGQIFVILNSRKAVADLLDARSQIYSDRPRTIMCKDLIGWDGSVVLSNN
TPRFRDCRKLLRKGLGPSAVQSFIPFLNRQSAFYLENLQKRPEAFVDIFKRNAAAISMKI
AYGYDGIQDDEELYGIGAMANHYFAETAVVGVWPVDMLPILRHVPQWFPFAYFKKYAAQA
KPIVLESVNRPFEETKRHMKRGTAGGSFTSMLLEDAKGDPETEDCIKWSGTGIFLGQMDT
TTSALSWFFLSMVLHPEVQAKAQAEIDKVVGNERLPRFEDKESLPYVSAVMQEVFRWHPV
VPMIPHALSKDDEYRGYFIPAKTSLIGNIWAIMHDESLYPDAEDFRPERFTEDGAPDCLN
VAFGFGRRVCPGILIAQAHVFVSIATTLATFNITKARDAQGNIIEPVVEDTPGAINFPQP
FKVSLEPRSAAAADLIRRSAEHSKTLPERLEIFSLDA
CYP5147A2 Phanerochaete chrysosporium
JGI gene model ug.50.57.1
this seq matches an unannotated region scaf 50 178-179kb
ug.50.57 is from the first 5 kb of this scaffold,
about 170 kb away from this seq.
this matches my scaffold_15f. The ug # is wrong.
MLDVGATAAAGLLLVFLLGLGLMKTQHLPPGPRGLPLLGNVLQIPRRLPHVAFRDMGHKY
GGDIVTLRVPGYNLLVLNSRQAIYDLLDSRSAVYSDRPQGTIYRKLLRKGLGASAVQSFI
PFLNRQSALYLENLQSRPEAFVEITKRNAAAISMKIAYGYDGIADDEELYRLAHQTTIYF
AETAVLGAWPVDMFPILRFIPSWFPLAYFRRYAARARPVVVECINKPFEETKRHMRLGSA
GASFTSMLLGDANGDPDTEDYIKWSSAAIFLGQMDTTTAVLSWFYLAMALHPEVQAKAQA
EIDQVVGNERLPHIEDRDSLPYVCAVMREVFRWHPVANLVPHATDKDDHYRDYFVPAQTV
AIANVWAVLHDEDVYHDADKFIPERFSEEGAPDSLEIAFGFGRRACPGKVVGQAHVFASI
ATVLATFNITKARDAQGNVIEPEVMDTPGAVNTPQPFKVNIEPRSEAAVDLIRRSAEHSR
TLPERLEIFSLDA
CYP5147A3 Phanerochaete chrysosporium
JGI gene model pc.16.140.1
MLLFAAVSTVLALLLASVLTKARRKARNLPPGPKPLPFIGNAHQIPPENEWIKFKEWGDE
YGDLVKIKIPGSMLYIVNKRKVVDELFEARSAVYCSRPNFIMASLSGWDHSIPTLPYGQR
LRESRKLLKKGTSPAAVKTYHPYINRDLPFFLENMLSTPDKFVEHYNRNAARIALKIAYG
YEGITEDERIIQGGVKAMEVFSATAVPGVWAVDTFPFLRHLPSWAPFSSFKGFAERCKRI
TDEALNTPFYEVKQRLEKGTADGSFTSVMLSTEKLDPETEEIIKWCATGIFTGQFDTTTA
TLSWFTMAMAKYPDVQEKAQAEIDRVVGRDRLPEVGDRDSLPYTWAILQETMRWHPTVAL
VPHTAIQDDTYGGYFVPAGTTVIANVWAMMHDENVYHDADKFMPERFYEEGAPDSLSVVF
GFGRRICPGLVVAQTHMFVTIASILATLNISKARDNAGNVIEPREDAKSGVINFPKPFQV
SITPRSDAAVQLIRRSVEHSKTLPDKLELFSP
CYP5147A4 Phanerochaete chrysosporium
JGI gene model pc.16.141.1
IFTAVLAVTVVSLLTRRKNGRHVPPGPKPLPFIGNALQIPPQHEWIKFKEWYGPRLRESR
KMLKKGMGPAAVKTYYPYINREVPFFLENMLRKPDSFVEHLKIAYGYEGVTEDEKIIRGG
VDAMEVFSAVAAPGVWVVKYVPSWFPFAKFKKFAERGKKITDEALDTPFYEVKRRVTTAT
LSWFTLAMAKYPEVQKKAQAEIDRVIGKDRLPEVGDRDSLPYVWAIMQETFRWHPTITMS
GYVPHTAIQDDEYRGYFIPSGTTLMANIWRERRSWPISGACPLRLMFEVIYHVHRGILHD
EKLYHDADKFIPERFCDEGAPDSLSVAFGFGRRRRVCPGLVIAQTHVFVTMASMLATFNI
TKARDSTGAVIEPREDAKSGVIPKPFVVSITPRSDEAVTLIRRSV
CYP5147B1 Phanerochaete chrysosporium
JGI gene model pc.50.95.1
MLLQVLAAIAALFVLSGLLNSRRRNMHVPPGPKALPLLGNVLDIPKKDVHVTFRDWANIY
GKDLMKVEMPGETLYVISNKKVMVDLFEARSAIYSSKPTMTMADSSGFKNSIPLLPYNAR
LKTSRRLLKQGLSPAAVRSYFPYINNRTALFLEALLKDPDDFVRHFTRTAAHTALKIAYG
YEGVTEDHHLLHTAIETMEIFATVVNPGRWLVDTLPILDRIPVSFPFANFKRVQEESRPV
VFETVSKPFEEVKKHLAEGTADGSFSSYLLQSEKPDPETEDCIRWAATSIFLGQFDTTTA
TLSWFTHAMVKFPEVQKKAQEEIDRVIGNDRLPEIQDRDSLPYVNAIMKEIFRWQPIISM
LPRSVVQDDEYNGYFVPAGTYLLANIWAVLHDPEVYPEPEKFMPERHLKEGVPNPLDVTF
GFGRRVCPGMQVAQSQTFGTMAAMLATLHLKPQKDEHGRDIIPETRTVDGLIRFPVPFKC
AFVPRSEAALKLIERGAEHARSVPDRLERWSD
CYP5147C1 Phanerochaete chrysosporium
JGI gene model pc.50.96.1
MVQASDTLLSVVVCAALITLTSFLLSGYRKRNAHLPPGPKPLPIIGNLHQLPDLKADRAV
AFRDMSLAYGSDILCVKVPGMLMYILNSKESMFDILVTRSAKSSSKPPQVMADEXLSGWK
YTVPSLPYGQRIKTSRRLLHKGLGPSAVQSYIPYLERESAFFLEKLLDQQDAYKKHVTHT
AARIALKIAYGYEGVTDDAHLIDTAVKAMNIFCVTATPGIWLVDSLPFLQHMPSWFPGTG
FKKQASQWSQTVLYAINHPFEELKRQMAAGTAGASFAGRLLEVEDLSDPEVEDCIKHCST
GIFAGQFDTTTAVMSWFAVVMAFYPEIQKKAQDEINKVVGHERMPVVADRDSLPYVNAIL
KELLRWRPVLPLIAHSVNEEDEYKGYYVPKDTVILANVWAVLHDESNYDEPEKYKPERFL
RDGILDPSVLDPATLAFGFGRRICPGMHIGQTLLFILMSRTLQNFDIAPAKDAHGREIAI
DTSAVPGLIGFPKPFKVSLVPRSNAHATHIRHAAEHARSLPDKLAIFEL
CYP5148A1 Phanerochaete chrysosporium
JGI gene model pc.79.37.1
RWAKTFGPLYSMWIGNQLFVVISDPQIVKDLVITNGAIFSSRKDMYVKSQIIFRGRGITT
TPYGDTWRKHRRLASQFLGNRVVSGYLSGLEYEVQDMLCGLLTDGQAGFVPVSPQAYLGR
LALNNIMTIVFGTRTGSIDDPFIHHWLTLSREFMNCTGPVSNWVDFVPFXCMAKFLLDVK
DKERLDDLDIILLCCGFLVGGVESTAAIKQWFAAHISVLPEVQAQAQMELDRVVGRDRLP
QAEDAKDLPYVRAIVKEIERVHNPFWLGTPHMSTEDFSYRGYKIPKDTAVILNTYTMHHD
SQRYPNPEKFDPDRYIDDERSSAESAKLADPYQRDHWTFGAGRRICPAIALAEHEIFLSV
AGLLWAFDMRQLSDAPIDLKEYDGLSGRSPVPFCIRLVPRHERVAAVVGASCHTATCRNG
CYP5148A2 Phanerochaete chrysosporium
JGI gene model ug.50.57.1|whiterot1
= pc.50.1.1 + pc.50.2.1 (This is the correct ug number)
TFVLLVAGILYIVLPFFFRKNLVDKNGNSIPPGPLLRLPYLPDYPERTLHAWAQKFGPLY
SFFIGNQLYVVVSDANVARELLVNNGAIFSSRKQYFTKNQTILRGRAITASPYGETWRQH
RKIAAQLLTPKAIQSYNNVLDYEARIMIRSMYKESMQGAVPINPAHYTGRYTLNNMLTIS
FAMRTESTQDPLIQRILAMAMEFNDLTGPFSNLVDFIEPLQWLPTKTHARAAKLHDDFIE
VYGSMVMAVKERMDAGENVPHCLAKVLIEGQQQEKLDWEDVCMLSAAFALGGVHSVSGLR
WFLALIGKHPDIQARAHHELDAVVGRDRWPMAEDEKDLPFIRAIIKEVLRVHAPFWNATP
HSSTEDFVYNGMYIPKGAAVILNCFTLHHNEARYPDPYVFPHCASYCLCANAMERDHWSF
GAGRRICPGINVAERILFLAISRLLWAFTVH
CYP5148B1 Aspergillus clavatus
47% to CYP5148A2
see fungal pages for seq
CYP5148B2P Aspergillus oryzae
even the stop codon and frameshift are conserved
see fungal pages for seq
CYP5148B2P Aspergillus flavus
100% to CYP5148B2P Aspergillus oryzae
see fungal pages for seq
CYP5148B3 Metarhizium anisopliae var. acridum Ma102
CYP5148B3 Metarhizium anisopliae var. anisopliae Ma23
CYP5148B4v1 Postia placenta (brown rot basidiomycete fungi)
CYP5148B4v2 Postia placenta (brown rot basidiomycete fungi)
CYP5148B5 confidential basidiomycete
CYP5148B6 confidential basidiomycete
CYP5148B7 confidential basidiomycete
CYP5148B8P confidential basidiomycete
CYP5148C1P confidential basidiomycete
CYP5149A1 Phanerochaete chrysosporium
JGI gene model gx.62.25.1
MORE COMPLETE VERSION OF pc.62.64.1
SEAYLPPGPPALPFVGNLFQLPRKSVPRTFATMSQQYGPLYY
MRVINRHFVIVNDLDLARILFDKRGAIYSHRPRLPMAQEVVKRDTMLFMNYGPEFRKSRK
LVSTFLNQRNASKYWPAQEIESLKFVLAVQRNPSDWLKLTRWTATSLVIRLLYGIEVQDK
DDALVGLAEDFARLTTETTEPGRWLVDAFPILRHVPAWLPGAGFKRWAKRAKARMDEFAT
LPYVMAKDKIEKGDITPCWTAEKLLETTEPLTEQDEKEIRHTATSMYSGTNAMVATFILL
MLHYPEVQKKAQEEIDSVTGGTWVPGMRDRERFPYINCLVKELFRFSPAVPLVPHSLHED
DVVEGYLIPKGSWVMANMWAFMHDEARYPDPETFTPERFEARPGVEPQDDPLDIVFGFGR
RACPGYLLGVASVYLNIVHLLFAFDIAPVKDAAGASVLPPIEFSDGHVA
HAKPFECDMRERSAERIALIEHTA
CYP5149B1 Postia placenta (brown rot basidiomycete fungi)
CYP5150A1 Phanerochaete chrysosporium
JGI gene model pc.24.95.1
POSSIBLE GC BOUNDARY AT ETMRL
scaffold_1 (3273479 bp) : 2653416:2656338 (2923 bp)
MAFSLPLISATVLLWVLWKVFRNYVVSSPLDNIPGPPRSSFWS (1)
GDSAIMYQRHGWSFHDNISEKYGPVSTTHTLLG (0)
ARGLYVYDQPKALNSIMITDQDSYEEPAWLLQ (2)
SSHAIFGPAVFIAQ (1)
GEQHRRQRRVLNPVFSGAHMRHMAPVFYDVAHR (0)
LRx (frameshift)
AVSAQIHDPASSEIDVLEWTSRAALELIGQGGLGCSLDPL
VADSNNDFGTALKTLI (2)
PLISGLHFYRMLMPYITPFVPLSVRRLFMRWVPHKNAQ
QLRAATEDLWALSRQIYEEKLAAVAKGDNDEVFEGQDLISIL (1)
IRSNTAAAAEDRLPEEEIIAQVA (2)
GLILAATDTTSSALARILHILAERQDIQDKVRAELVEAAGEGEDI
PYDQLVNLPWLDAICRETMRL (2)
HPPANIVNRE (2)
ARTDVIMPLSEPVQGRDGTLIHEIAVPKGTLVTISVRGCN
RNKAIWGEDALEWKPERWLKSLPETVSGAHIPGVYAH (2)
MTFIGGARACL (2)
GFRFAQLEM (1)
KVVLAVMLRSFRFQLSDKEVYWNFAGVVFPSIGRDGKTASMPMKIETL*
CYP5150A2 Phanerochaete chrysosporium
JGI gene model fgenesh1_pg.C_scaffold_2000178 [Phchr1:1200]
= gx.121.14.1 LOCATED ON VER 2 SCAFF 2, 527-529KB
58% TO CYP5150A4, 53% TO CYP5150A1, 51% TO CYP5150A5
55% to CYP5150A3, 49% to CYP5150B1
MTSAPLLAFGAALIAIIWTLFQGYLVKSPLDNIPGPERSSFWLGNHGDIFNRHAWNFHDR
ARQLFGPVFRFWGPFASRGLFVYDPKALNSIIVKDQLIYEESRWFISWNKYAFGLGLLST
LGEHHRKQRKLLNPVFSINHMRHMAPIFYQTTHRLRTAITAELEASSADVDVLNWMGRLA
LELIGQGGLGYSFDTLVAHTHNEFGDAIKGYVPAILNVIILRNIIYPYMDEYIPAKVRRF
ILDILPFRSVRRIQKIIDDMHSHSRRIFNEKKAALEKGDG
AVLHQVGEGKDIMSILLKANMEASDEDRLPEDELIGQMT (2)
TLVFAATDTTSNALSRILELLAKNQ
DVQDKMRTELIAASPDGEDIPYDTLVALPYMDAVCRETLRLHPPVNMMSRETREDVMMPL
SEPIQGVNGETISEIFVPKDTSVIVSIRACNRNKAIWGEDADEWKPERWLSPLPEAVGNA
HVPGVYSHLMTFLGGGRACM (2)
GFKFSQLEM (1)
KVVLAVMLRTFKFFPGKNEIYWNMGGVNYPTAGKDSNKACMYLRLERIAS*
CYP5150A3 Phanerochaete chrysosporium
JGI gene model pc.153.5.1 LOCATED ON VER 2 SCAFF 2
scaffold_2 (3043971 bp) : 1623404:1625693 (-) strand
(whole gene range)
57% to CYP5150A4, 56% to CYP5150A2, 51% to CYP5150A5, 51% to CYP5150A1,
47% to CYP5150B1
MVPPSTFVLCALGGWVFWKLFRGYFTRSPLDNIPGPRRASLLK (1)
GNAHQLFNRHAWGFHERISQEYGQVVKFHAPFG (0)
GRGLYVFDPKALYHMIVKDIATFDEPRWFLQ (2)
MADFTFGPGLFSTS (1)
GQQHRKHRRVLNPVFSINHMRNLAPLFYTVAHRLRDGLSTQLTTSTGGE
VEILGWMGRAALELVGQGGFCHSFDQLDKNVPNAYRDVLKEVM (2)
PSQIALHFWRILLPYAVEYVPARIRRFLAPW
LPHPVMQKYRNICITMDEQARAI
YHAKKVALEQGDKLVEHQACEGRDILSVL (1)
VTANKQESVEDRLSEEEVIALIS (2)
TLAFFAATDTTSNAMARILHLLAEHQHVQDKMRLELFEAGM
DGEDIPYDRLVELPYLDAVCRETLRL (2)
YPPVLFMNRE (2)
TRQDAVLPLSKPIQGLDGDVLTEIMVPKGTLLMVSIVACNRNKALWGEDVLEWKPERWLS
PLPESIREAHVPGVYSHL (2)
LTFLGGGRACM (2)
GSKFAQLEM (1)
KVLLCTLLRSYRFMPGTKGVYWNVGAISYPTPNEIDEKAAMYLTMDHIQAPQ*
CYP5150A4 Phanerochaete chrysosporium
JGI gene models genewise.95.20.1
fgenesh1_pg.C_scaffold_2000729 [Phchr1:1751] = gw.95.20.1
scaffold_2(3043971 bp):2185130:2187482 (2353 bp)
whole gene range
57% TO CYP5150A3, 55% TO CYP5150A5, 54% TO CYP5150A1,
51% TO CYP5150B1, 58% TO CYP5150A2,
MATTTHGLALYALCGLCVWALWRVLRAYVVKSPLDNVPGPERTSFLK (1)
GNTHQIFSRHGLDYLQELGERYGQVVRYYAPLG (0)
ARGLYVFDPKALNHIVVKDQAIYEEPRWFIR (2)
LNRLLFGPGLLSTL (1)
GDHHRKQRKLLNPVFSINHMRHMTPIFYNVVHD (0)
LRDAVAEQVKDTPT
EVNVLDWMLRTALELVGQGGLGYSFDALSAQKRNVYGEALKELL (2)
PTVFALHFWRVLLPYVGAVVPAWVCRAAAPFLPHAAMQKLRRVV
GAMDAHSRRIYEMKKGLLEKGDAAVVHQVSEGRDILSIL (1)
MKANREVDEEDRLPEDEIIAQMS (2)
TLVFAATDTTSNALARIFQLLAEHPDVQDRLRAELT
DAAPDGADIPYDALVVLPYLDAVCRETLRL (2)
HPPASFMNRE (2)
ARADAVLPLAEPLRGADGAPITEIAVPRGTPLIIAIRASNRN
SALWGADALAWRPERWLAPLPDALAKAHVPGIYANL (2)
MTFLGGGRACM (2)
GFKFSQLEM (1)
KVVLAVMLRSFRFLPGDKEIYWNLAPVAYPTVG
KTSTKSELYLKLEPLKT*
CYP5150A5 Phanerochaete chrysosporium
JGI gene model pc.10.108.1
AADS01000067.1
54% TO CYP5150A1
scaffold_8 (1906386 bp) : 331157:333480 (2324 bp)
whole gene range
MGPLQLVLVATAA
5407 WALWRLFRHYILRSPLDNIPGPASSSFIY (1) 5499
5550 GNLKEMFNRHGWGFHDTIIRQYGPIATVHSMLG (0) 5648
5713 ARALYVYDPKALNHIILKDQYTYDEPGWFLE (2) 5787
WHRMIFGPTLIATT (1)
5936 GAHHRKQRKLLNAIFSIARMRDTAPIFYNVAHR (0)
LRDAISADLN
6116 QGSGEINMIEWFSRAALELAGRGGVAYSFDALEANSENSEF
GMTVKQYR (2)
6345 PTTIALHFWRILSPYASLYIPRVVRLALGRLVPHKDLQ 6443
RIQMIAHAISAQSKKIYDFRMAAFQRGDEDAVREISEGRDVLSYI (1)
IRAGLNSEEERLPEEEILAHMS
6752 SGLILGATDTTSNALARTFQLLAEHQDVQDKMRAELA
DAAPDGEDIPYDQLVHLPLLDAVCRETLRL (2)
NPPIGLLARE (2)
7091 ARDDIVLPFLQPVHGRDGSLINEVPVPKGSTVFISVRACN
RNPLIWGEDAAEWKPERWLQPTPKSLSEARVPGVYANQ (2) 7312
7377 MTFLGGDRACL (2)
GFKFSQLEM (1)
KVVLAVLL 7556
7557 RSFRFLPCNKDVYWNLAGITYPTLGKDSDKLELPIKLEIIGGQY* 7676
CYP5150B1 Phanerochaete chrysosporium
JGI gene model fgenesh1_pg.C_scaffold_2000954 [Phchr1:1976]
= gx.66.11.1
LOCATED ON VER 2 SCAFF 2, 2927193
51% TO CYP5150A4, 45% TO CYP5150A1, 44% TO CYP5150A5
49% to CYP5150A2, 47% to CYP5150A3
MSLFALAIPWVACGLVLMLVYRLVRDYVVSSSLEDVQGPTPRSLIY (1)
GNLPELQNRGAWPFLDHLTNDYDRVVRMRGMFG (0)
KRILWVADPKALHHIVVKDQDIYEEAPSAITF (2)
GRKLGMGPGLLSTL (1)
GDHHRRQRKLLNPVFSIAHLRRVTPVFYEVMNR (0)
LSKGIEKQLDTTSNNEVDLLAWMGRAALELIGQGGFG
HSFDPLVEQTPNPYADAVKSLV (2)
PAITGLIFYRMVIHLVDPLVEACAAHPALGAFIKRWFW
LVPNARMQHVKTIFDVLHDTSTAIYTEKKIALDSDDPELKMRVLEGRDLM (1)
SVMLRENMNADAADRLPEREIIAQIT (2)
TFIFAGTDTTSNALARILHLLCLHPDVQEKLRAEIIEARAQNGGGDLDYDALVALPYLEAVCRETLRL (2)
YAPVPFVSRQ (2)
ARSDALLPLSAPLTLRDGSRVSALHVPQGTSVLVAIHSVNRSAALWGADAHVWRPERW
LEKLPDAVAEARVPGVYSNL (2)
MTFIGGGRACM (2)
GFKFSQLEM (1)
EVVLATLLSSFRFSLCDGKNADIVWNRAGIAYPTVGNDGGHPSLPLRVERLKC*
CYP5150C1 Trametes versicolor
GenEMBL EB077269.1 cDNA clone
52% TO CYP5150A2, 50% TO CYP5150B1
SHVMAQVLQLLSEHPDAQAKVRREILEAGDGYIPYEKLHSLPYLDAICKETLRMYPPTPI
VLREAFRDTTLPLSQPMRGSDGSMLSHIPIPKGTNVLVGVRACNRNKALWGEDAEEWKPE
RWLAPLPKAVEDASIPGVYSNLMTFVGGGRSCVGFTFSQLEMKVVLSSLLANFTFQLSEK
PIFWHISAITFPSAAKDSLKPEMWLKVGRYTGEAA*
CYP5150D1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D3a Postia placenta (brown rot basidiomycete fungi)
CYP5150D3b Postia placenta (brown rot basidiomycete fungi)
CYP5150D4 Postia placenta (brown rot basidiomycete fungi)
CYP5150D5 Postia placenta (brown rot basidiomycete fungi)
CYP5150D6 Postia placenta (brown rot basidiomycete fungi)
CYP5150D7 Postia placenta (brown rot basidiomycete fungi)
CYP5150D8 Postia placenta (brown rot basidiomycete fungi)
CYP5150D9 Postia placenta (brown rot basidiomycete fungi)
CYP5150D10 Postia placenta (brown rot basidiomycete fungi)
CYP5150D11v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D11v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D12v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D12v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D13v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D13v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D14v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D14v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D15v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D16v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D16v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D16v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D17v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150D17v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150D18 Postia placenta (brown rot basidiomycete fungi)
CYP5150D19 Postia placenta (brown rot basidiomycete fungi)
CYP5150D20 Postia placenta (brown rot basidiomycete fungi)
CYP5150D21 Postia placenta (brown rot basidiomycete fungi)
CYP5150D22 Postia placenta (brown rot basidiomycete fungi)
CYP5150D23 confidential basidiomycete
CYP5150D24 confidential basidiomycete
CYP5150D25 confidential basidiomycete
CYP5150D26P confidential basidiomycete
CYP5150D27 confidential basidiomycete
CYP5150D28 confidential basidiomycete
CYP5150D29 confidential basidiomycete
CYP5150E1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5150E1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5150E2 confidential basidiomycete
CYP5150F1 Postia placenta (brown rot basidiomycete fungi)
CYP5150G1 confidential basidiomycete
CYP5150H1P confidential basidiomycete
CYP5150J1 confidential basidiomycete
CYP5150J2 confidential basidiomycete
CYP5150J3 confidential basidiomycete
CYP5150J4 confidential basidiomycete
CYP5150J5 confidential basidiomycete
CYP5150J6 confidential basidiomycete
CYP5150J7 confidential basidiomycete
CYP5150J8 confidential basidiomycete
CYP5150J9 confidential basidiomycete
CYP5150J10 confidential basidiomycete
CYP5150K1 confidential basidiomycete
CYP5150K2 confidential basidiomycete
CYP5150K3 confidential basidiomycete
CYP5150L1 confidential basidiomycete
CYP5150L2 confidential basidiomycete
CYP5150L3 confidential basidiomycete
CYP5150L4 confidential basidiomycete
CYP5150L5 confidential basidiomycete
CYP5150L6 confidential basidiomycete
CYP5150L7 confidential basidiomycete
CYP5150L8 confidential basidiomycete
CYP5150L9 confidential basidiomycete
CYP5150M1 confidential basidiomycete
CYP5150M2 confidential basidiomycete
CYP5150M3 confidential basidiomycete
CYP5150M4 confidential basidiomycete
CYP5150M5 confidential basidiomycete
CYP5150M6P confidential basidiomycete
CYP5150M7 confidential basidiomycete
CYP5150N1P confidential basidiomycete
CYP5151A1 Phanerochaete chrysosporium
JGI gene model pc.8.82.1 (model # is not right
pc.8.80.1 is correct (-) strand)
C-term is 37% to CYP5033A1 Ustilago maydis 30% overall
Phanerochaete chrysosporium cDNA clone DV765344
MESFTLAALSLTTACAAALVAYLLYLCV
VYPLRNPIRQLPGPPSKWFLELRHMYMTMD (2)
PRRSPHTAAEFVEKYGRNVYIRGPVPWDQRLFTLDPVTMNHVLQHT
AIYEKPWPSRRLISGLIGAGMLSAEGQMHKRQRR
VATPAFSLNEMRALIPLVFSKGT
ELQKKWMEIMRDAGVKPGQ
GHVVNVCSWA
SRATFDVMGSAGFDYEFNAIQNEDNELLRAYVDMF
ETAVSKQKAGLRSVLVMYLPIIDKIF (0)
159857 PNETTRFVSKCQTVIERVAGTLIQEKKRKMADAAVKGQVY 159738
159737 QGKDLLSLMRKY (1) 159702
159661 VKSNSAVDLPPDQRLS159572
DQDLLNNINTFMFAGTDTTSLALTWTLYVLALYPHVQDRLRAELLS
VAPIAPIDTLTPEE
VQSLYAEIAALPFLENVIRETLRLIPPVHSSIREATRDDVV
PVSAPLKRTTPNGRVVEEQVHQIVVPKGTFIHVPIEGFNLDKGL
WGETAWKFD (2)
PDRWDNLPETIKELPGLYQHTLTFSAGPR (0)
ACIGMRMSVIELKSFLFTLVTNFKFAPDPTQKIGKANV (2)
ILTRPYVAGKQNEGSALPLIVTPYVREDAS*
CYP5151A2 Coprinopsis cinerea strain okayama7#130
GenEMBL AACS01000049.1
WHOLE PREDICTED SEQ 55% TO PHANEROCHAETE CYP5151A1
MNPILLSGLAAASTVLTWVVYRVVIEPRFNPLLKLAGPPSPGLF
GTNLAPVLSPTVSPRLHEVYAENYGRSMRIRGVGPWDERLLTLDPVSVAYVLKNSTIY
EKPWQSRALITSLIGCGMLAAEGQVHKRQRRVGTPAFSIQNLRGIVPLVFKKGTELKD
KWMEMIETTGEVRGSDEKEKSMVVDVCHWVSRATFDVIGVAGFDYQFNAIQNESNELF
NAYKEMFEIAISQGDGIITLISIYAPWIHKIFPNQVSRTVERCQEVIRRVAGQIIQEK
KRKIAEGEASGKPYQGRDLLSLLLKSNVAVDLPEDQRISDEDILNNVNTFMFAGSDTS
SLTLTWTLWLLANNPEIQDRLRAELLAAIPDTELTADISSLNEDEIQTLYGIIAELPL
LNNVTRESIRLIPPVHSSIRVATQDDEIPTRYPVKLADGTIDTKQSVKIAKGSFVHVA
VEGFNLDKEFWGADAWDFNPDRWDDQPETARQLPGLYNNTLTFSAGPR(0)
3476 SCIGMRFSMIEIKTFLYILVTRFVFKPTKDKIIKSNV 3586
3642 VLTRPYISGKYREGSQLPLIVTPYIPSAEH 3731
CYP5151A3 Postia placenta (brown rot basidiomycete fungi)
CYP5151B1 Trametes versicolor
GenEMBL EB072414.1 cDNA clone mRNA sequence.
45% to CYP5151A1
PNELNAAFQEVFNPGANFTIFTILKNVFPALDIFPDERAKRLDHAQDVMRRIGLQLIEEK
KAQIAREMSEGKSGGVERKDVQGRDLLTLLMKANMATDIPDNQRLSDEDVLAQVPTFLVA
GHETTSTATMWCLYALTQAPDVQKKLRDELFTLQTEAPTMDELSSLPYLDAVVRETLRIH
APVPTTMRVATKDDVIPVSEPFVDRRGKVQDSIHISKGSPIIIPVLSLNRSTELWGADAL
EFRPERWINPPETISSIPGVWGHILSFLAGPRACIGYRFSLVEMKALLFELVRAFEFE
CYP5152A1 Phanerochaete chrysosporium
JGI gene model pc.24.121.1
65% TO CYP5152A2, 42% TO CYP530A1 N. crassa
NOTE: 5144C1 IS AT 2402616-2402515 REGION SCAF_1
5144A6 IS 2479233-2479132 REGION (-) STRAND SCAF_1
THIS SEQ IS AT 2699101-2698997 (-) STRAND SCAF_1
CYP5152A2 IS AT 2713991-2713887 REGION (-) STRAND SCAF_1
same as model fgenesh1_pg.C_scaffold_1000845 [Phchr1:845]
N-term is in a seq gap possible frameshift after FSFK
FKFAQLTEMYGPVFSFKQGTRVVCVVGRHQ (0)
AAVEIMQKH GADLADRPRSIAAGELLSGGKRTLLVGAGDRLRKLRK (2)
ALHSHLQPSVAVQYRPMQLKHALNVILDILRDPEHHIDHARR (2)
YAASVVMT
MTYGKTEPTYYTDPEVQEILLHGTRLGSVIPLDYHKVDRFPILKHVPFVTSTLRQWHKEELALFS
DLVDGARARL (0)
RDGAPPSFATYLIDQQQQFGLSDDEIAYLAGSMFGAGSDTSATAIAFVIMAAATHPKAQAEVQAQ
LDSVVGRDR (1)
VPSFDDESLLPLVTAFYLEAYRWRPVSYG (1)
GFAHKATADIRW (0)
GEYVIPADAIVIGNHWSIARDPDVFPEPEEFRPSRWLDESGKLREDLSSF
NFGFGRR (2)
VCVGQHVANN (2)
SLFINTALILWAFSVGEDPAQPIDTMAFTDTANVRVHPFKAVYEPRIPRLREVVETYLD*
CYP5152A2 Phanerochaete chrysosporium
JGI gene models pc.24.126.1 and
fgenesh1_pg.C_scaffold_1000848 [Phchr1:848]
35% to CYP5065A2
TATAIS exon IS AT 2713991-2713887 REGION (-) STRAND SCAF_1
possible GC boundary at PISWG
MATGLLADVLARVQVPALALLFALLLLRAALRIVQRQRVPLPPGPPG
RWFEPGPKAPLRYAELAKTYGPVFAFRRGGQLVCIINSYK (0)
DAVEIMQKRGADLADRPDFIAAGDFLSGGMRTLLVGAGERVRRLRRC
RALHSQLQPTAAVQHKPVQFRAALDLVLDVLHDPADHLNHTKR (2)
FAASLILTMTYGKTTPTRYSDAEVREINVHTTRLGTVVPAGLHAVDRHPVLR
HVPPATATLRRWHREELALFTRMVDGVRKDV (0)
HVARPSFTTYLLEHQEEYGLSDDELAYLAGSMFGAGSDS (0)
TATAISFVMMAAATHPQAQAQVQAQLDSVVGRDR (1)
VPTFDDEKLLPLVVAFYLETFRWRPISWG (1)
GFAHRATSDIVWNDYVIPAGATVFGNHWAIGHDETVFSDPDVFRPSRW
LDEAGKLRDDISPFTYGFGRR (2)
VCVGQHVANN (2)
SLFINTALLLWAFNIREDPKVSIDTMGFTDSGTVRVLPFHV
QFHPRIEHLREIVESSMPEDVYSAA*
CYP5152A3v1 Postia placenta (brown rot basidiomycete fungi)
CYP5152A3v2 Postia placenta (brown rot basidiomycete fungi)
CYP5152A4 Postia placenta (brown rot basidiomycete fungi)
CYP5152B1 Puccinia graminis f. sp. tritici
45% TO CYP5152A2
MMELIPATMRLIHNEIVQNFRIIFSLFICILSPVILSKITHRRRRLPLPPGPKSYPFIGYSFGPYHWRQMEKITKEYGPV
SSVRLGNNKLLVIVGRVEPALALLEGRSSIYCDRPQLEMAGNIMSGGLRTLCLPYGDRWKRFRR (2)
VLHSQLDTKAATSF (0)
YQPIQERASRQLILDI
LERPKDFTEALTRYAASVIIKITYGKLTPIHHSDDEVVQVIKTLTRFSKAARIGAHAVDRFPWLRYIPGWVAQGRKWHQE
ELNLFSSQVDGVRREMNIPGKRDSCFASYMLERQKEFSLSDNEAAYLAGSLFGAGSDTTAVMVLAAALAIVIFAAACHPE
EVKKVQEELGSVVGNGRMPTFDDYFELPLVTAFVCETFRWRPASAAGFMHATVKDDVYEGHFIPAGSWVVGNHWSIHRDE
SVFPDPDKFDLMRWLTIDDKTGKTVLRQDMRHFAYGFGRRRCAGITIADRTFEDATNSRPKPFEVDFVPRVPDLRRAIE
MSAC
CYP5152B2 confidential basidiomycete
CYP5153A1 Phanerochaete chrysosporium
JGI gene models gx.27.66.1 = pc.27.122
fgenesh1_pg.C_scaffold_1000958
Phchr1/scaffold_1:3068242-3069378
32% TO CYP5116B1 Aspergillus nidulans
The unbroken reading frame starting with FNMYQ is
preceded by a conserved non-p450 seq upstream that
probably ends 460 bp before FNMYQ. The true P450 N-terminal
must reside in between or this is a pseudogene missing the
true N-terminal. The two short exons shown below are my best
guess for the N-terminal, but they do not resemble other
P450s, and the total length is only 443 aa, a little short,
so the pseudogene alternative may be correct.
MVHDSGGAIFDTAGPALVR (1)
RTITVYPSDSLVQRGIQTNLELILKHIYTCEVSPIHPHLAPLHQ (0)
FNMYQTIVWYFTAVLFLLGAVVARARKRPVTSSLERIQLTDLRDIRELLAPISTSLPIL
LEQRSVPNARLVRAFGITNTFVSSSVDVHATFSREARALIAGNDWDRFAQCAQLAVDKCI
EERTDAGTVMRYDTLMQNAALLSILMGLFEVALDDVPIADLGVVARGINDLWKLSKTADT
LPPHMLPEINTRLRAWLPAHQNPVDLIIPAFETMWRVVATTVAYTHADPLAHAVLETFLA
DPTSTAFASARSGTPSVDALVTEAIRLHPPTSRISRHVVSNSTKGAVLVADVGALHRDPT
IWGADAEVFNPLRHQQRTPTQEKALLGFGAGRVMCVASRWAPHAAGIIVA
SISERIGREIQVREGKAKGGRDWDGWFVECI*
CYP5154A1 Phanerochaete chrysosporium
JGI gene models gx.18.4.1
temp name PFF_258a
63% TO CYP5154A2P, C-term 38% to 5141A4
Scaf_6 ver2 (-) strand 503798-505808
505808 MQDLGYLPGLRSLVTPMSPLGFALPPSQYNPGRDWQW 505728
505655 VYRDAGTETISAIPYVFGPP (1) 505596
LAKQVVSTKGQ (2)
505458 ILRLLCSLWGPNIFAANGEEWRKHRRIINPAFSNAT (2) 505363
FASVWEQTSRVFDEMEVGEGWAGKHTVNLPVVNGLTNK (0)
505139 LALILISTCGFGNPLKWQFTNSASGGMSFEKALSIVSSNHI
ALLLIPDWMYRLPNK (2) 504972
IRELKTAVDRMNLFMRELIEKRRAEMAQKAPERTDILSAMIK (2)
504735 LSWLSRFDNDCDKVGNTFLLLSAGH (1) 504661
504611 DTVAHTLDAAFALLALHQDFQEEVYQELLEVMPTEADFV 504494
504443 TYENSARLVKTRACFLEASRMFRI (2) 504372
SGFMLIRDTAEDVVLQNVGPNNDDVLPLKRGTRVVVDMIGL (1)
504143 HHNPRIFPDPEAFKPERWYNAHENDMSMFSFGARA (1) 504042
503989 CIGRKFAVAEGICFLAKLLRRWRVEPLAKEGETKEQWKQRVV
RGVVVLNLGIGEVPVRLVRRNC* 503798
CYP5154A2P Phanerochaete chrysosporium
JGI gene models gx.18.4.1
temp name PFF_258b
This one is looking like a pseudogene, no EXXR motif,
No N-term Met
Scaf_6 ver2 (+) strand 509278-511252
62% to PFF_258a in overlapping regions
509278 YLPGIRSLVSPMSALGASIPTSRWNPGRHWQW 509373
509448 VYRDAGTETIAAVPYLFGPPII 509513
509662 GPNIFAANGGEWKKHRRVINPAFSQET 509742
509963 LALILISTCGFSNPLSWQ 510016
510040 MPFADALWIVSTRIIARLLLPRWVYWLP 510123
510371 DYNMHQLGDTFLLLTAGHGT 510430
510478 MLALHPDFQEECYREILKVMHTNDDFV 510558
510606 TFGNSTHLIKTRSCFLEASSLYRM 510686
510727 AAGEILVQDVAEDTILRGAAPDGGDPPVPRETPIVVDMLGLR 510852
510906 DHNPKLYSDPEKFLPERWYNTHENDRTMFSIGAQA (1) 511010
511067 CLGRHFALVEGTCFLARLLRIWRVVPLLRPG
ETVEQWRAKIGVEALFNFGIGNVPLKFVRR* 511252
CYP5155A1 Phanerochaete chrysosporium
JGI gene models fgenesh1_pg.C_scaffold_7000377 [Phchr1:4564]
Same gene as pc.81.7.1
whole seq is 40% to CYP5150A4
REMOVED POSSIBLE SHORT INTRON SEQ VKAAKNKYLEDGRSTASTWE
MAVGLPEVVLAAIFAYLLYRETWGKKTALSDVAGPPRESWMK (1)
GNTQRLFRDALDYNLWLSRTYGTAVKMYSLY (1)
ALYLSDPLALHHVFVKDQNSFDVSDAFIH (2)
NLLMFGEGLTGTL (1)
GEQHKKQRKMLNPVFSVSNLRELLPVIQPIANKMASVFVEQIPAD (1)
AREIDVMPWLSRGAQEYMSQACFGWTFNALDLNKRNTYSEAARKYT (2)
PAALRVSWLRPYLPFIVRTIPLTLRTKMLDWYPGSDMKDFLYILDVM
HQTSKRIFEQKKKALDSTVLEKADAETSERSEGDLGP (0)
GKDIMSILLK
ANASSNEADRMTDSEMIGQMSTLLFAGFETTTYAISRILWVLASHPDAQARIRSE (0)
DVSLSYDDLMALPYLDAVIKETLRVYPPSSVHFRVALQNTTLPLQYPVKSVNDTPITTIPVEKGT
QILVSIIASNHNTNVWGPDASEWKPERWLNSDDKAVPKATTDSAKYPGVYSGMMTFLGGPRGCIGFKFSE
MEAKQVLATLLPRLHFALPSAVDEQGRRKEVYWMMSGPQIPVVRPPFGDGMTAQVPLDVRLVREEDFAYG
FEDEDLIKL*
CYP5156A1 Phanerochaete chrysosporium
JGI gene models gx.17.28.1
fgenesh1_pg.C_scaffold_7000309 [Phchr1:4496]
34% TO CYP602B1 Fusarium graminearum
scaffold_7 (2051558 bp) : 939436:940306 region
N-TERM in model SEEMS TOO LONG. Remove it.
29% to 609A1
MYPLGLLTIVQHFETRDAALKLAIALPSIVLLALLFSWVSARKDQD
EGPPFLPLSIWETVWPFFTSRHDFLRRGFELTRHPAFRFKLLQ (0)
HTVVVVSQEHARADFFACRGLDIHEGFKVLSGA (0)
IPMLPGVTSDLQTRRINLIHRRLAAAQGGDHLQR (1)
LVPFIVQDIRQGFCSWGSTESLIDPFTRIPA (0)
LLFQTTVRCLGSHELADDGATVARLLSLYDTLDRSTTPLSVLLPWLP
SPSMLAKLRASKQVYDIVDGAIRARVASGVSRDDTLQILLDHGDEKMVIVG (0)
FIMGLLVAGARSTGTT (1)
ASWIVTFLAGHPEWRRKVREEIHALLSLYAATTAHCANDPAELLATVPLEAFEQCMP
ATDAVIRETLRIAQPHTAMRRNVGPDTYIAGTRIPSGAYVVYPFSDIHLDPRLYPD
PWRFDPSRPESKSNIGYVGWGG (1)
GRTVCLGQRIAKLQIKLVLSMFLLHYDFDLVDQDEHPLGNVPR
PNWNDHLTCKPPSGSCLVRLAKQ*
CYP5156A2 Gloeophyllum trabeum
GenEMBL EB008493.1, EB007318.1 ESTs
61% TO CYP5156A1
LADIPLSAWEGSTPVLDAVIRETLRLAQPHTAMRRNVGPDLVIDGKTVPSGAYVVY
PFSDVHLDADIYPDPWRFDPGRPADAKRAHAWVGWGGGKTVCLGQRLAKLEMKIIA
AMFLVGFDYAVVDKAGKPADPLPKPNWNDALMCRPEAGSCYVK
YERAASSTSSSSSSSPSSPSSPL*
CYP5156A3 Postia placenta (brown rot basidiomycete fungi)
CYP5156A4 confidential basidiomycete
CYP5156B1 Lentinula edodes
GenEMBL EB016637.1 EST
50% to CYP5156A1 N-TERM ONLY
MPYSVGLQAAGAALLSAGLPVLFTTAIIVLLLIISINSSLQKDVADAPARLPI
YSFFTIIPFFRRRFDFLNWGFQATGQSTFQFDLLRNKVIVVSGESARQAFFTAKGLDLTE
GFKILSGAIPMVRGVTSDLQTKRISLIHKRLAAVQKNEQLSMLIRPMLEDSRRLMESWGN
SGCFDPFDNIYELVFQLTVRSLSCTEISDDPCLVSRLKKLYDTLDVGTTPATVLLPWLPT
PAMVKKLWATKEIYDIVVAAITAR
CYP5156C1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_15000299|Aspni1
34% to CYP4F11 aa 375-490 52% to 5156A2 frameshift after TTNY
see fungal pages for sequence
CYP5157A1 Phanerochaete chrysosporium
JGI gene models genewise.21.71.1
fgenesh1_pg.C_scaffold_9000353 [Phchr1:5749]
scaffold_9 (1898532 bp) : 1276291:1276784 (494 bp)
Phchr1/scaffold_9:1276084-1278363
30% to 608A1 Magnaporthe grisea over 412 aa
MSLLPPLTNLASGHISFFLGIPRGELFLLFLPFVVLIAFVLFKRIIQATKRKHASTRPL
CVLVSTDRPIDQLPPYHYRPTSKRFATMDLLSALRGREREYTKYVFADDKSLSFEEGAA
TILNLRFLLKIRGGRFYKDVDKLITSGIIPRIEAITNKIYPIFMRHARRLVEDGQKNNG
CVDFFAHTNHSIAESMLTVVMGEVGIYENLSWFSRTFPRLSKFSRLRDGLSDNGCPRLR
LLFGTLIYRYFFVLGPYVWRELRNNKFEPLARSEKEHDANESVLRYLGRMFAREDGTVS
AVDTCWCMCLMLSLIFASVHQTAVVAVWVMYELASRPTYIPAIREELLAVAELQADGSH
YLSYDSLRNARLLDSFIREVMRLKGDTLGVCRQTVQDTPMGQYVIPKGHLVIPMASLSH
RSREYHGQDAEVFDGFRWVERNLPAVMVGPTYFPFGMNRWACPGRVLAVSEMKMIALTI
LALADPTLEGGKYTVVDPLNTTSVQPAGKLYLTPLARPLI*
CYP5158A1 Phanerochaete chrysosporium
JGI gene models none
39% to 5037B2, 36% to 5037B3, 36% to 5144A5
scaffold_2 2356566-2358785
2356566 MLTSQVSIAKLTTLPTSYYA
2356626 LLATIALLALLFARRTQQPTPPGPRGLPIIGNVAELSGGFEWIRFGTTLRKQF (1) 2356784
GDVLGFKVLNNRILVLNTAKAAKEFMDKRASKYSSRPVLTVIGELMGLDQ (0)
AMPLIPYGAEWRACRKLEHVALNQSAVKQYRPVIEHHAAQLALDILQEPDKFLTHTRL (2)
IILAVTYGLSARVTATE (0)
YISLAEEVMRIVTIYLRPFAHLCDVMPV (1)
LKHLPSWIPFRREAEYGRRLFESFVSTPYERTKQAF (0)
AKGDAEPSLIRDILASMPQDSLTPEVEHRVKWTAGFALLA (1)
SGGES (0)
2357970 TFGTIGVFMMAMALHPDKQARAQEEVDSAVGTDRLPTMDDKARLPYVYAVVQEA 2358131
2358132 MRWHPMLPL (1) 2358158
2358208 SLPRRAEVDDEYDGYYIAKDTTVCANLW (2) 2358291
2358346 AMGMEPNVKYPPEQFIPERFLDAEHPTPNPNTWAFGFGRR (2) 2358465
ICPGKALAEESLFVLMSTLLAMFEICAPPEGIKPEFESRVVR (2)
2358702 LPKPFKCIFRLRSPEKADMLRAVVATQ* 2358785
CYP5158A2P Phanerochaete chrysosporium
JGI gene models gx.89.1.1 pseudogene
92% to CYP5158A1
scaffold_2 2396927-2398113
2396927 MLTSQVLIAKLTALPTSCYA
2396987 LLATAALLALLSARRTQQPTPPGPCELPIIGNVAELSGGFEWTRFGTTLRKQF (1) 2397145
GDVLGF
large deletion here, missing 6 exons
SGGES (0)
2397300 TFGTIGVFMMAMALHPDKQARAQEEIDSAVGTDRLPTMDDKARLPYVYAVVQEA 2397461
2397462 MRWHPMLPL 2397488
2397541 LPRRAEVDDEYDGYHIAKDTTVCANLWY 2397624
2397685 MEPNVKYPPEQFIPERFLDAEHPTPNPNTWAFGFGRR 2397795
2397854 ICPGKALAEESLLVLMSTLLAMFEICAPPEGIKPEFESRVVR 2397979
2398033 LPKSFKCIFRLRSPEKADPPRAIAAAQ 2398113
CYP5158B1 Postia placenta (brown rot basidiomycete fungi)
CYP5158B2 Postia placenta (brown rot basidiomycete fungi)
CYP5158B3 confidential basidiomycete
CYP5159A1 Coprinopsis cinerea strain okayama7#130,
GenEMBL AACS01000290 REGION: 167200..168432
39% TO CYP5153A1
MLDWQSTSIVIAAFLLASLLCLIAISLNQESAVGHSSLGGIRQL
FSPDGADVGTLLADRARPNQRLVRAFGITNTFVSPHPSVHRSFVTAARSLLSRANKRG
WGTFRDISTQAIHVELSLARSGSVNYGIFIQAVTLRVILVGLLGANVPMEDFSPDDIY
TAASHINKLWSLSKDPSPIPSHLLPELNDALRRLLPDITTFPNPVDIVIPAWETFWRV
VATTVAYSHNSKAITQLFLDFYAYPTDNAFREANADANISPKNVVEESMRLQPPSKHI
ARKTIRPSLSKLPKPIANLLVRFLPRISWVKHYADVQAVLRSPAIWGSNSLEFNPWRH
NQDPSSTLPSRAEALGYIFGGGNLRCIGSSWAPVAAAVVASAVFDAVDRGVCSIVPGR
AVGGRNGWEDWSVTDTKN
CYP5160A1 Phaeodactylum tricornutum (diatom)
CT887000.1
estExt_fgenesh1_pg.C_chr_100123|Phatr2 (at JGI)
45% to CYP5160B1 in Ectocarpus siliculosus
MNILFSKPDWFRVLLLSALALRCRPVEAVPGQTLVHLVQDTLYNLRNEDNSNLVYSSIVAFLLMVLLQRFYRHRAMLCYG
MPVMTHPPQGRPWPFLGHALNFLSYRPWDLLMSWHNLYGPIVCFDLLGSTMFSLASPSLLKLVLQSKIQSVKKDISNTMK
HFIVILGTGIVTSENQSWIKQRLKMSHPLRVEVLEMIPRQTLLAVQRWMTKLDAACETQESVEVGSSLRHLTLQVISGTF
LSLSAEESDSTFAKMYLPIVDESNLRVWHPYRAYLFMLPVFWKYLWNVHNLNRYVSHLIRVRWLVRQQERINGGSVRTQD
ILDGVLKAHEKEFPHQMNLPEMAVRQFRDEMKTFMLAGHETSAAMMTWTLYELLANTALMQRVSEEGASLFARNVDWSRA
GADELPSNDQLKHLILSEACLRESLRKYSVVPIVARRTVEDLYLEDGKYFIPKGSSFLINIQAIHHDPNLWPNPMRFDPD
RFVDGEIVPYTFLPFIAGPRNCLGQHLALLESKMVISLLAQRYIFSLGEGATLEVDDWENDKDPRHRFMVPVVPKEELKV
TVQRK*
CYP5160B1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
45% to Phaeodactylum CYP5160A1 probable ortholog
Ectocarpus sctg_25 976310-968389
CYP5161A1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
46% to CYP5161B1
Ectocarpus sctg_193 165935-174483
CYP5161B1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAA2YH16FM1.SCF, LQ0AAB82YO01FM1.SCF
LQ0AAB56YO08FM1.SCF, LQ0AAB52YG02FM1.SCF
LQ0AAB89YF12FM1.SCF, LQ0AAB84YD09FM1.SCF
LQ0AAB68YD07FM1.SCF, LQ0AAB80YM13FM1.SCF
LQ0AAB76YH20FM1.SCF, LQ0AAA22YB02FM1.SCF
LQ0AAB79YP24FM1.SCF, LQ0AAB82YG03FM1.SCF
46% to CYP5161A1
Ectocarpus sctg_10 809434-798741
CYP5162A1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAB94YO15FM1.SCF, LQ0AAB94YO15RM1.SCF
LQ0AAA19YP10FM1.SCF, LQ0AAB47YF02FM1.SCF
LQ0AAB15YK11FM1.SCF, LQ0AAB9YA01FM1.SCF
LQ0AAB46YP02FM1.SCF
some similarity to CYP5021A1 from diatoms
(2 phase 0 GC) boundaries confirmed by ESTs
Ectocarpus sctg_362 85804-78355
CYP5163A1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAB4YG18FM1.SCF, LQ0AAB5YG18FM1.SCF
62% to CYP5163A2 (+) strand
Ectocarpus sctg_471 54372-59195
CYP5163A2 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAA20YH19FM1.SCF, LQ0AAA7YM05FM1.SCF
LQ0AAB47YN20FM1.SCF, LQ0AAB14YC16FM1.SCF
LQ0AAB82YE22FM1.SCF, LQ0AAB83YE22FM1.SCF
62% to CYP5163A1 (-) strand
Ectocarpus sctg_471 76672-68528
CYP5164A1P Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
This duplicated gene may be a pseudogene of CYP5164A2
There is no start Met and the first exon has a frameshift
There are no ESTs for this gene but several for CYP5164A2.
76% to CYP5164A2, note: heme signature is aberrant
cannot determine the first exon
Ectocarpus sctg_60 429421-434903
CYP5164A2 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAB84YE20FM1.SCF, LQ0AAB49YL03FM1.SCF
LQ0AAB63YM09FM1.SCF
52% to CYP5164B1
76% to CYP5164A1, note: heme signature is aberrant
cannot determine the first exon
Ectocarpus sctg_60 447096-442032
CYP5164B1 Ectocarpus siliculosus (brown algae)
Genoscope Ectocarpus siliculosus brown algae project
ESTs LQ0AAB83YG11FM1.SCF, LQ0AAB64YL01FM1.SCF
LQ0AAB3YN10FM1.SCF
52% to CYP5164A2
cannot determine the first exon
Ectocarpus sctg_111 487670-501540
CYP5165A1 Phaeodactylum tricornutum (diatom)
estExt_fgenesh1_pg.C_chr_20220|Phatr2 (at JGI)
71% to CYP5165A2
this gene model was automatically generated at JGI
I have not checked it, but the high similarity to CYP5165A2
acts as a built in check.
MILYVDEASNLDPWWQTTALAIVVLGIAYAFTRRRSFQRKDGKQYPPYAPIGLLRTILSMSGPRAPSFMLEMSRLLKCSV
FRVRLPIPGTPMVVAVGEPILTKLILTESRMKPASVYKPFESVTKGPSIFTETDETTWKHARKGVAPAFSSQHIRRMNTI
CAAHTERWIQERLVPSIANNAVLDIATEMVDLTVTVICESAFEYNPSKEEMTMFLSELDLALREFSFKQSANPLRKFFNG
VLPSARRAKVASDRLQRFVFKVMDHYRSLKHHETEDTVIGRIMNNDKYKNDEARAADLLTFLVAGHDTTGYSLAWILLHL
AQHPHEQKILREKLQATPREEWAQSAGLRSVVQEGMRLSPVAAMGSVRQLAEDIVSPTDPTIVLPKGAIVFLPQILACRN
PDVFDSPDEFQPSRWDEPSELQRAAIIPFSLGPRNCVGQRLAVAELHSVIASVCAKYTFTVEDEGTSDYFLTYKPVGALL
KATHVPNQ*
CYP5165A2 Phaeodactylum tricornutum (diatom)
estExt_fgenesh1_pg.C_chr_20219|Phatr2 (at JGI)
71% to CYP5165A1
this gene model was automatically generated at JGI
I have not checked it, but the high similarity to CYP5165A2
acts as a built in check.
MVFLNGQYDQGDWWQSFALAAVTLGLLFIFLTKGRSEGKDGKQYPPYAPAGLWETALSVSGSQAPSFMIQMARELNCSVF
RMRLPIFGTPMVVAVGEPLLTKAVLTDSGSIKPAVIYKAFHNVTKGPNIFSETNLVLWKHARRGVSPAFSTQHVQRMNSI
CAQQTERWIKERLVPAIENETAFDIAQAMRDLTVSVLCEAAFEYDPTEEDMRTFLFETETAMREFSFKQSANPMRQWFAW
VLPEVRRARLATDRMQAFGFKVMNHYRSLKHHETEDTVIGRIMNNDKYKNDAARAADILTLLVAGHDTTGYSLAWILLNL
AQHPHEQTILREELQTMPKEERAQCQAVRNVIQEGMRISPVAAVSSVREIAKDIVSPSDPTIILPKGSIVFLPQILACRN
PDVFDAPDEFLPSRWNNPSELQRTAVIPFILGSRNCVGQRLAIAEIHSVIARLCTDFEFFVEDEGTSEYFLTYKPVGALL
KARRVQK*
CYP5166A1 Phaeodactylum tricornutum (diatom)
phatr1_ua_kg.chr_5000041|Phatr2 (at JGI)
this gene model was automatically generated at JGI
I have not checked it, it may have some errors
MSLSKQRIPKEDIPVPLRQWNTFHWELNILSAVALYGVYEFVIPATHRTLAHVVLGLLALDATRYYYSRGTLAGVPYTLP
LVTILAMLARPVRFWTELAHIALQSVDGLCANQLVGNFMVFVTDPALCREIMTGEADYGIYAHPNAMWLFGEKNLIYIAS
EPHKAIRAILTPALFSKNALGLYAMHQERVVRQYLAKFVEICQQPGKDAHIDALVSFRTMAAASSQEAFLGPYLNDDLRH
HLEQDIVTFTMGFLSFPFPYLGGLRRAIQAKNRIEATVHDVIPKARAWVQAGNEPRCLLEFWSLAIQNAAKEQNVSAQDV
PGCQDDDVARTVLDFLFAAQDATNSALTYSLDVLGGHRNVLQSMRNEVDAECGDGPIHAKAHAADSLVYVAKVANQMLHH
KPPVPMIPHICKRNVTLAGHALKKGTVVIPSITYSARVGGGSLEFNPLRDDADAQFVKTVTFGAGQHKCPGRKYAESLLN
VFMAVLAQEYDFERVADQRPGVDDFIYFPTVFPTDTRFVIQKRVKATE*
CYP5167A1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_3000005|Aspni1
38% to CYP5068B1
see fungal pages for sequence
CYP5168A1 Aspergillus niger
JGI gene model gw1.13.785.1|Aspni1
36% to CYP670A1, 38% to gw1.4.1072.1, AM270073.1, REVISED 2/10/2009
see fungal pages for sequence
CYP5168A2 Aspergillus clavatus
54% to CYP5168A1
see fungal pages for sequence
CYP5169A1 Aspergillus niger
JGI gene model e_gw1.18.102.1|Aspni1
37% to 630B11
see fungal pages for sequence
CYP5170A1v1 Aspergillus niger
JGI gene model estExt_GeneWisePlus.C_30253|Aspni1 revised
40% to CYP5102A1 aa 98-492
see fungal pages for sequence
CYP5170A1v2 Aspergillus niger CBS 513.88
XM_001390853.1
93% to estExt_GeneWisePlus.C_30253 (allele)
see fungal pages for sequence
CYP5171A1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_4000449|Aspni1
37% to CYP590A1
see fungal pages for sequence
CYP5171A2P Coccidioides immitis
pseudogene fragment (C-term)
54% to CYP5171A1
see fungal pages for sequence
CYP5171B1 Histoplasma capsulatum G217B
47% to CYP5171A1
see fungal pages for sequence
CYP5172A1 Aspergillus niger
JGI gene model e_gw1.9.995.1|Aspni1
37% to CYP5112A1
see fungal pages for sequence
CYP5173A1 Aspergillus niger
JGI gene model e_gw1.6.1215.1|Aspni1
38% to CYP526A2
see fungal pages for sequence
CYP5174A1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_5000290|Aspni1
34% to CYP578C1
see fungal pages for sequence
CYP5174A2 Uncinocarpus reesii
83% TO CYP5174A1 A. niger
see fungal pages for sequence
CYP5175A5 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_2000360|Aspni1
34% to CYP54B1 aa 171-515, 44% to gw1.4.1134.1
see fungal pages for sequence
CYP5175B1 Aspergillus niger
JGI gene model gw1.4.1134.1|Aspni1
36% to CYP54C1 aa 275-516, 44% to fgenesh1_pg.C_scaffold_2000360
see fungal pages for sequence
CYP5176A1 Aspergillus niger
JGI gene model e_gw1.4.1066.1|Aspni1
32% to 671A1
see fungal pages for sequence
CYP5177A1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_6000319|Aspni1
35% to CYP5116A1
see fungal pages for sequence
CYP5178A1 Aspergillus niger
JGI gene model e_gw1.16.101.1|Aspni1
31% to CYP680A1
see fungal pages for sequence
CYP5179A1 Aspergillus niger
JGI gene model gw1.5.246.1|Aspni1
29% to CYP547C2
boundary between first and second exon not clear
see fungal pages for sequence
CYP5179B1 Aspergillus terreus
41% to CYP5179A1 Aspergillus niger
see fungal pages for sequence
CYP5180A1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_9000194|Aspni1
28% to CYP5125A1
see fungal pages for sequence
CYP5181A1 Aspergillus niger
JGI gene model estExt_fgenesh1_pg.C_100184|Aspni1
31% to CYP534C1
see fungal pages for sequence
CYP5182A1 Aspergillus niger
JGI gene model fgenesh1_pg.C_scaffold_11000427|Aspni1
33% to CYP609A1
see fungal pages for sequence
CYP5183A1 Aspergillus niger
JGI gene model e_gw1.7.1018.1|Aspni1
34% to CYP660A1
see fungal pages for sequence
CYP5184A1 Aspergillus niger
JGI gene model gw1.4.1747.1|Aspni1
32% to CYP640A1
see fungal pages for sequence
CYP5185A1 Aspergillus niger
JGI gene model gw1.1.1982.1|Aspni1
45% to CYP5083A1 aa 298-455
see fungal pages for sequence
CYP5186A1 Penicillium citrinum
BD294644 patent seq orf16
10500-12300 (+) region MFS transporter (orf17)
13160-15000 (-) region = P450 (orf16) 32% TO CYP660A1
METIGLNITLLSLKTWIAIAVVAFALARFVLWPSGDPK
EPFYVPARLPLLGHAINIYNKGSRYFVEIG (2)
SKKYKLPIYSLPVPGGRVYVVNTPELLTSVDRNPKAIAFGPIAAMVIERLSGSKGRAA 1293
SALREDVTGPNSANGYMNAVLKQIHHTLAPGPLLEKVTDAVITDLNDSIGGLQHKETTIH 1113
LLEWFRHNFSMSSTNAIYGPKNPFKDPKVENGFW 1011
FDYAVSNLLITPKASWTTPQGDKGRSD 869
AWNGFIDYFRQGGHNEGSEMAKQRYEVAIAKGIPIDDIGRLEVTMIIGVLTNTVPAGFWM 689
TYYIWSTPGLLDELRGELDKIIIRETQPDGRPKLTLRSADIKQDCPLLYATMQETLRMRT 509
CGISSRIVTEDIVLNDQYLVKKDSVMELPNNIIHSAEDLWGPTVCQFNNKRFIK-GHPDY 332
RVPKNGFRPFGGGVSLCAGRHQATSQLLSALGFLVAAFDISPTKGAWDFPGAHGHTIAAA 152
MDSPDHDVQVKLQPRQGYEDAVWTLKP*
CYP5187A1 Mycosphaerella graminicola
38% to 65L1, all top hits are to CYP65 sequences,
but low 30% range for many
see fungal pages for sequence
CYP5188A1 Mycosphaerella graminicola
38% to CYP65F1 Magnaporthe grisea, all the top hits are CYP65 members
see fungal pages for sequence
CYP5188A2 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_11000257
65% to CYP5188A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5189A1 Mycosphaerella graminicola
JGI gene model gw1.13.670.1|Mycgr3
This seq is like no other P450 except at the low 20% range
This seq is 45% to CYP5189B
see fungal pages for sequence
CYP5189B1 Hypocrea lixii cDNA AJ894250.1
(anamorph: Trichoderma harzianum)
WIPRAAGLYPARTFRTTQKKYKDSPYTLLMGGVKFHVFGSPSAATHVFARSRTYAYEPV
TMSMLENGLDLPVADRVHFQIGLDRANSSDNEKGFVLQNHNVWLRYLSGEPLDDLM*LFT
REFHQVLEQYVDMKTRDWQTVDLYEVLRKVIFDTSVVTFFGPRLAQIWGPTMWEDFCLFN
NATYIGVRTNLAYVLQPRAGRARERMLRAFEEWLSHQSEGDWPDK
CYP5190A1 Mycosphaerella graminicola
JGI gene model fgenesh1_pg.C_chr_4000706|Mycgr3
32% to CYP5116A1 Aspergillus oryzae
CYP5190B1 Mycosphaerella fijiensis
JGI gene model e_gw1.6.477.1
41% to CYP5190A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5191A1 Mycosphaerella graminicola
32% TO CYP559B1 Magnaporthe grisea
C-term from JGI model e_gw1.1.632.1|Mycgr3 revised
see fungal pages for sequence
CYP5191A2P Mycosphaerella fijiensis
JGI gene model e_gw1.41.26.1
46% to CYP5191A1 Mycosphaerella graminicola
45% to CYP5195A1 Mycosphaerella graminicola
note this match is to the bottom part only
There may be some overlap in the CYP5191 and CYP5195 families
see fungal pages for sequence
CYP5192A1 Mycosphaerella graminicola
34% to CYP59D1 new family
see fungal pages for sequence
CYP5192B1 Mycosphaerella fijiensis
JGI gene model gw1.15.75.1
48% to CYP5192A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5193A1 Mycosphaerella graminicola
35% to CYP609A1 Magnaporthe grisea
see fungal pages for sequence
CYP5194A1 Mycosphaerella graminicola
38% to CYP570C1 Fusarium graminearum
38% to 527C1
see fungal pages for sequence
CYP5194A2 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1Plus.C_150125
59% to CYP5194A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5195A1 Mycosphaerella graminicola
31% to CYP606B1 Fusarium graminearum
40% to CYP5191A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5195A2 Mycosphaerella fijiensis
JGI gene model e_gw1.34.29.1
51% to CYP5195A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5195B1 Mycosphaerella fijiensis
JGI gene model e_gw1.8.136.1
44% to CYP5195A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5196A1 Mycosphaerella graminicola
41% to CYP5076A2, 39% to 5076E1, 41% to 628C1 (may be a new family)
52% to CYP5196A2
see fungal pages for sequence
CYP5196A2 Mycosphaerella graminicola
52% to CYP5196A1, 44% to CYP5196B1, 38% to CYP5076A2
see fungal pages for sequence
CYP5196A3 Mycosphaerella fijiensis
JGI gene model e_gw1.9.877.1
63% to CYP5196A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5196A4 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1Plus.C_21242
74% to CYP5196A2 Mycosphaerella graminicola
see fungal pages for sequence
CYP5196B1 Mycosphaerella graminicola
39% to 5076D1 38% to 628A2 (may be a new family) 44% to CYP5196A2
see fungal pages for sequence
CYP5196C1 Mycosphaerella fijiensis
JGI gene model e_gw1.29.250.1
47% to CYP5196B1 Mycosphaerella graminicola
42% to CYP5196A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5196D1P Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_9000123
47% to CYP5196C1 Mycosphaerella fijiensis
see fungal pages for sequence
CYP5197A1 Mycosphaerella graminicola
JGI gene model e_gw.3.299.1 revised
33% to CYP5044A1 (new family)
see fungal pages for sequence
CYP5197A2P Mycosphaerella fijiensis
JGI gene model gw1.17.231.1 revised,
missing the N-term about 216 aa
49% to CYP5197A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5198A1 Mycosphaerella graminicola
37% to 547B1, top 8 hits are all CYP547 members
(new family related to CYP547)
see fungal pages for sequence
CYP5199A1 Mycosphaerella graminicola
35% to CYP65G1
see fungal pages for sequence
CYP5199A2 Mycosphaerella fijiensis
JGI gene model gw1.8.141.1
68% to CYP5199A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5200A1 Mycosphaerella graminicola
40% to 596B1, 42% to 596C1, 39% to 68D1, 41% to 68D2
see fungal pages for sequence
CYP5201A1 Mycosphaerella graminicola
38% to CYP657B1 Aspergillus fumigatus
see fungal pages for sequence
CYP5201A2 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_50542
61% to CYP5201A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5201B1 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1Plus.C_130099
46% to CYP5201A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5202A1 Mycosphaerella graminicola
JGI gene model estExt_Genewise1Plus.C_chr_21393|Mycgr3
37% to CYP52G3 Aspergillus oryzae (new family?) C-term from JGI model
N-term from the genome seq
see fungal pages for sequence
CYP5203A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
36% to CYP5025A1, 35% to 544A1 in the CYP52 clan
70% to CYP5203A2
P450-16_var1
see fungal pages for sequence
CYP5203A2 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
70% to CYP5203A1 in the CYP52 clan
P450-17_var1
see fungal pages for sequence
CYP5203A3 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
70% to CYP5203A4 in the CYP52 clan
P450-41_var1
see fungal pages for sequence
CYP5203A4 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
56% to CYP5203A2 in the CYP52 clan, 35% to CYP5025A1
P450-21
see fungal pages for sequence
CYP5203A5 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
65% to CYP5203A2 in the CYP52 clan
P450-43_var1
see fungal pages for sequence
CYP5203A6 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.66.9.1
73% to CYP5203A2 Rhizopus oryzae
see fungal pages for sequence
CYP5203A7 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_550057
57% to CYP5203A5 Rhizopus oryzae
57% to CYP5203A6
see fungal pages for sequence
CYP5203A8 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.39.12.1
63% to CYP5203A6 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5203A9 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.37__72
63% to CYP5203A5 Rhizopus oryzae
see fungal pages for sequence
CYP5203A10 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_310060
79% to CYP5203A7 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5203A11 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_Genewise1Plus.C_310065
60% to CYP5203A6 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5204A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
26% to 512G2, 26% to 512B1, 27% to 512G1, 24% to 54A1
possibly in CYP54 clan
P450-2
see fungal pages for sequence
CYP5204B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.1__581
47% to CYP5204A1 Rhizopus oryzae
see fungal pages for sequence
CYP5205A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
33% to CYP505A15 A. niger, 31% to CYP505D6 in the CYP505 clan
P450-27
see fungal pages for sequence
CYP5205A2 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
79% to P450-27 in CYP505 clan
P450-50
see fungal pages for sequence
CYP5205A3 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.15.208.1 short model
JGI gene model fgeneshPB_pg.15__173 (best model)
60% to CYP5205A2 Rhizopus oryzae
in the CYP505 clan
see fungal pages for sequence
CYP5205A4 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.15.206.1 short model
JGI gene model fgeneshPB_pg.15__167 (best model)
88% to CYP5205A3 Phycomyces blakesleeanus
in the CYP505 clan
see fungal pages for sequence
CYP5206A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
27% to CYP5148A2, 28% to CYP5050A1, 28% to CYP5046A2
24% to CYP504C1, in the CYP64 clan
60% to P450-38, 60% to P450-19, 60% to P450-18_var1,
53% to P450-48, 49% to P450-47, 56% to P450-5
P450-3
see fungal pages for sequence
CYP5206A2 Rhizopus oryzae
94% to P450-3 with some variations in the CYP64 clan
P450-23
see fungal pages for sequence
CYP5206A3 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
83% to P450-5, but P450-5 has an insert before I-helix
P450-18_var1
see fungal pages for sequence
CYP5206A4 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina
EST = EE007880.1 in CYP64 clan)
59% to C-term part of P450-3, 54% if yellow is deleted
(missing in EST EE008707.1 from P450 38
remove MQNRNLIFCEPNTILFQSG it is intron seq not found in EST EE007880.1
83% to CYP5206A3
P450-5
see fungal pages for sequence
CYP5206A5 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
77% to P450-18_var1 in CYP64 clan
P450-19
see fungal pages for sequence
CYP5206A6 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
61% to P450-18_var1 in CYP64 clan
P450-38
see fungal pages for sequence
CYP5206A7 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
52% to P450-38 in CYP64 clan added green at I-helix intron boundary
P450-47
see fungal pages for sequence
CYP5206A8 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
92% to P450-47 in CYP64 clan added green at I-helix intron boundary
52% to P450-38
P450-48
see fungal pages for sequence
CYP5206B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model gw1.3.485.1 revised
39% to CYP5206A6 Rhizopus oryzae
joined with fgeneshPB_pg.3__834 = N-term part
aa boundary between TDII and YLAD
see fungal pages for sequence
CYP5206C1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.10__160
46% to CYP5206B1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206C2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model gw1.1.533.1
75% to CYP5206C1
see fungal pages for sequence
CYP5206D1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_Genewise1.C_260073
51% to CYP5206C1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206E1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.53__1
48% to CYP5206C1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206F1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_180202
42% to CYP5206D1
see fungal pages for sequence
CYP5206G1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_210147
48% to CYP5206B1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206H1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_180113
45% to CYP5206D1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206J1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.2__921
46% to CYP5206F1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206J2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_Genewise1Plus.C_100002
85% to CYP5206J1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206K1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_Genewise1Plus.C_10687
47% to CYP5206C1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206L1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.6__211
also JGI gene model e_gw1.6.253.1 (join)
44% to CYP5206D1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206M1P Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model gw1.15.127.1 revised
47% to CYP5206K1 Phycomyces blakesleeanus
region in yellow does not match well and requires a frameshift
possible pseudogene
see fungal pages for sequence
CYP5206N1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.25.82.1
48% to CYP5206K1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5206P1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.6.211.1
52% to CYP5206C1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5207A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
56% to P450-20b, 55% to P450-37_var1, 52% to P450-35_var1,
47% to P450-9
35-36% to P450-3, 30% to CYP5050A1, 29% to CYP5069A1
28% to CYP665A1, in the CYP64 clan
P450-4_var1
see fungal pages for sequence
CYP5207A2 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
56% to P450-4_var1 in the CYP64 clan
P450-20b
see fungal pages for sequence
CYP5207A3 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
66% to P450-20b in the CYP64 clan 29% to CYP5069A1
P450-35_var1
see fungal pages for sequence
CYP5207A4 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
69% to P450-35_var1, yellow is an insertion YKIEKMTNERTRAINIKQT
in the CYP64 clan 29% to CYP5069A1
P450-37_var1
see fungal pages for sequence
CYP5207B1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
~45% to P450-4 with a gap in seq, Seq 4 is longer here
in CYP64 clan
P450-9
see fungal pages for sequence
CYP5208A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
35% to CYP5046A1, 32% to CYP5046A2 in the CYP64 clan
P450-44
see fungal pages for sequence
CYP5208B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.1__894
49% to CYP5208A1 Rhizopus oryzae
see fungal pages for sequence
CYP5208C1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_Genewise1Plus.C_60392
46% to CYP5208B1 Rhizopus oryzae
see fungal pages for sequence
CYP5209A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
24% to CYP5093A2, poor match to all P450s
25% to CYP504A5, 25% to 620B1
yellow region too long VSLMKEDKTGKK remove as intron
possible 64 clan
P450-6
see fungal pages for sequence
CYP5209B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_20032
42% to CYP5209A1
see fungal pages for sequence
CYP5210A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
33% to many different families CYP5070A1, CYP617D2, CYP547B2
new family in the CYP56 clan
P450-1
see fungal pages for sequence
CYP5210A2 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
90% to P450-1
This seq has a frameshift near the PERF motif, in CYP56 clan
P450-11
see fungal pages for sequence
CYP5210A3 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
73% to P450-1 in the CYP56 clan
P450-13
see fungal pages for sequence
CYP5210A4 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
100% to P450-13
P450-14
see fungal pages for sequence
CYP5210A5 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
60% to P450-13, 59% to P450-1, in the CYP56 clan, 34% to CYP5070A1
P450-26
see fungal pages for sequence
CYP5210A6 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.4.106.1
56% to CYP5210A5 Rhizopus oryzae
see fungal pages for sequence
CYP5211A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
28% to CYP547C3, 29% to 547C1 in the CYP56 clan
P450-25_var1
see fungal pages for sequence
CYP5211A2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.14__230
62% to CYP5211A1 P450-25_var1 Rhizopus oryzae
see fungal pages for sequence
CYP5212A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
35% to CYP509B1 in the CYP56 clan
P450-45
see fungal pages for sequence
CYP5213A1 Rhizopus oryzae (Zygomycete fungus, Mucoromycotina)
26% to CYP512B2, 25% to CYP512B1 in the CYP54 clan
P450-28
see fungal pages for sequence
CYP5215A1 Cryptococcus neoformans var. neoformans B-3501A chromosome 2
AAEY01000006
CNBB0620
EAL22841.1
CF712065.1 = mRNA yellow is an insertion
32% to AAEY01000032, 32% to CYP5151A1
see fungal pages for sequence
CYP5215A2 Cryptococcus neoformans serotype A
88% to CYP5215A1
see fungal pages for sequence
CYP5215A3P Cryptococcus gattii
CNBG_5445 Transcript 1 Broad Institute
80% to CYP5215A1 Cryptococcus neoformans var. neoformans B-3501A
gene model revised. This is a pseudogene
MMPEQLSLHLPTTIESMFALTVFALLWLLRVFVYKPFKSPLKEVSCPPGGTGSQGHIAEILDLQGTKVHDWIKAYG
TTFIVRGPFGVHHRIFSIDPRALNHVLKHTNIYTKSDLLRDLVRRYMEGGLIVGE
GEGEGHKVQRKVSQKLFSMGGPKSMGQVVQDKSNQ
RDILPNLCEDPTVSNP*PPVNPTLSTGS
REVDVYSTASRCIFDLVGSVGVDHQFGSLGNWEGSGGKLFQKYERMQLLCPGAMGF
RMLLSLTWPLIDKIWPSENIKRVNDAMGSLQKFAKEMMTERRLELSIIGSKKGDVPDRKG
LLTLMLRHNMAQKINAADSLQDHEISGQLSTFLFAGSETTAGTISFGLYDLTCHPDIQSR
LRTEILECGDNLPFDQIDELPYLDAVVKEIMRINPSLPGTVRQAQKDDIIPLAKPVTLTN
GKVVTDIHIRKGQLVHVPIEHLHTLEHIWGPAA*EFDPSRFFSSPQSSAFS &
QPTLGSHSAATSSARRDAVPSYVPEGPGIWPNFMTFIDGPRRCIGYKLAVMEIRTIIFTL
VGDFEIELMKGQHILRWNM (2)
MSNRPFVANTSWSKGSRLPLHFKLYKGGGQYEESVEFVSS*
CYP5216A1 Cryptococcus neoformans var. neoformans B-3501A chromosome 3
AAEY01000013
CNBC2600
EAL22122.1
34% to CYP63A4 Phanerochaete chrysosporium
see fungal pages for sequence
CYP5216A2 Cryptococcus neoformans serotype A
90% to CYP5216A1
see fungal pages for sequence
CYP5216A3 Cryptococcus gattii
CNBG_3491 Transcript 1 Broad Institute
85% to CYP5216A1 Cryptococcus neoformans var. neoformans B-3501A
85% to CYP5216A2 Cryptococcus neoformans serotype A
MKGGRFLLPALFKTLILPPLIAALFTHHFPSLSLSLTALIYLISLPALYVFRSYVSLVTS
SRRAAALGAVDIPRVKGAWPLNIDVLLNWAKSGTEEEVGRMMVLMGRQYGGTYNTRVLGE
DQIISSDPKVIKHVLIDDFDNFVKGQKFKDRAQNFLGDGIFNSDGDGWKFHRSLMRPFFH
PMYISPLHFTVNIQAFFNSLPLYGKAFDMQACIGQLALELAIMWLCGEDMSADASNVERT
DEWRKAKREIGWAMTEAQKVVGKRVKIGTVWPLFEITHDPLERPMKVIRAFFRPIISQAL
NRKRQRCKSDDQEDAYMIDRLVEATDDVKLVEDQLINVLLASRDTLASLLIFSVYAIALH
PDIAARLKNEIFSVASRESEVTKDTIRQLRYSRAFINEVLRLFPPVPLNIRRTLRPSLLP
TTSHLVYMPANTSIILATILMQRDPAVWGEDALVFNPDRWLAGGLGKQRENFASWNLGPR
MCLGQPFALTITHTFLVYFFRHIAHVGTLVGQNTTIQLALDAQPPKSLLPKEWMTSEGSD
GRTRGGRDRVWIVADVVLAIKGGLWVRFGAENTE*
CYP5217A1 Candida albicans SC5314
32% TO CYP537A1 N. crassa, orf19_3105
see fungal pages for sequence
CYP5217A1 Candida dublinensis
93% to CYP5217A1 Candida albicans (ortholog)
cdub_11-g19.1
see fungal pages for sequence
CYP5217A2 Candida lusitaniae
50% to CYP5217A1 Candida albicans (probable ortholog)
see fungal pages for sequence
CYP5217A3 Candida parapsilosis
56% to CYP5217A1 Candida dublinensis
see fungal pages for sequence
CYP5217A4 Candida guilliermondii
51% to CYP5217A2 Candida lusitaniae, yellow seems too long
54% to CYP5217A1 Candida dublinensis with yellow removed
see fungal pages for sequence
CYP5217A5 Debaryomyces hansenii
CAG85742.1
51% to CYP5217A1 Candida dublinensis
see fungal pages for sequence
CYP5217A6 Lodderomyces elongisporus
57% to CYP5217A3 Candida parapsilosis
see fungal pages for sequence
CYP5217A7 Pichia stipitis
JGI model e_gww1.7.1.292.1
57% to CYP5217A2 Candida lusitaniae
see fungal pages for sequence
CYP5218A1 Malassezia globosa
37% to CYP5031A1,
see fungal pages for sequence
CYP5219A1 Malassezia globosa
29% to CYP5218A1 Malassezia globosa
see fungal pages for sequence
CYP5220A1 Malassezia globosa
39% to CYP5046A2 Phaeosphaeria nodorum,
38% to CYP530A3 Aspergillus nidulans
identical sequences are on the same contig 9kb apart
see fungal pages for sequence
CYP5220A2 Malassezia globosa
39% to CYP5046A2 Phaeosphaeria nodorum,
38% to CYP530A3 Aspergillus nidulans
identical sequences are on the same contig 9kb apart
see fungal pages for sequence
CYP5221A1 Sporobolomyces roseus
43% to CYP5025A1 Ustilago maydis, e_gw1.5.259.1
43% to CYP557A1 AY316198 Rhodotorula sp
N-term added back from the genomic seq
see fungal pages for sequence
CYP5221B1 Puccinia graminis f. sp. Tritici
42% to CYP5221A1, 40% to CYP5025A1 Ustilago maydis
THIS FAMILY HAS THREE MICRO EXONS
see fungal pages for sequence
CYP5221B2 Puccinia graminis f. sp. Tritici
63% to CYP5221B1
see fungal pages for sequence
CYP5221B3 Puccinia graminis f. sp. Tritici
69% TO CYP5221B2
see fungal pages for sequence
CYP5221B4 Puccinia graminis f. sp. Tritici
51% to CYP5221B3, 52% to CYP5221B1, gc boundary at KKIK
see fungal pages for sequence
CYP5221B5 Puccinia graminis f. sp. Tritici
55% to CYP5221B3
see fungal pages for sequence
CYP5221B6 Puccinia graminis f. sp. Tritici
60% to CYP5221B2
see fungal pages for sequence
CYP5221B7 Puccinia graminis f. sp. Tritici
64% to CYP5221B5
see fungal pages for sequence
CYP5221C1 Puccinia graminis f. sp. Tritici
46% to CYP5221B1
see fungal pages for sequence
CYP5222A1 Sporobolomyces roseus
JGI model estExt_fgenesh1_pg.C_20096
24% to CYP634A1
see fungal pages for sequence
CYP5223A1 Yarrowia lipolytica
CAG79538.1
38% to CYP5217A1 Candida albicans
see fungal pages for sequence
CYP5224A1 Batrachochytrium dendrobatidis JEL423 (chytrid)
only 25% to CYP617D6 Aspergillus niger
26% to CYP509A1 Cunninghamella elegans
N-term part only, up to I-helix, added the rest from genomic seq
Supercontig 3 1051607 - 1053730 (-) strand
see fungal pages for sequence
CYP5224A2 Batrachochytrium dendrobatidis JEL423 (chytrid)
51% to CYP5224A1
see fungal pages for sequence
CYP5225A1 Batrachochytrium dendrobatidis JEL423 (chytrid)
frameshift at &, first exon is a guess.
see fungal pages for sequence
CYP5226A1 Batrachochytrium dendrobatidis JEL423
26% to CYP5224A1, heme signature is not correct, no CYS
see fungal pages for sequence
CYP5227A1 Batrachochytrium dendrobatidis JEL423
35% to CYP5224A1 Batrachochytrium dendrobatidis
see fungal pages for sequence
CYP5227A2 Batrachochytrium dendrobatidis JEL423
59% to CYP5227A1 Batrachochytrium dendrobatidis
35% to CYP5224A1 Batrachochytrium
see fungal pages for sequence
CYP5228A1 Batrachochytrium dendrobatidis JEL423
32% to CYP534D1 Mycosphaerella graminicola\
see fungal pages for sequence
CYP5229A1 Batrachochytrium dendrobatidis JEL423 (chytrid)
23% to CYP5225A1 no heme signature.
see fungal pages for sequence
CYP5230A1 Puccinia graminis f. sp. tritici
26% to CYP526F1, N-term seems long
see fungal pages for sequence
CYP5230A2 Puccinia graminis f. sp. Tritici
97% to CYP5230A1
see fungal pages for sequence
CYP5231A1 Puccinia graminis f. sp. Tritici
38% to CYP5093A4 Phaeosphaeria nodorum,
37% to CYP5065A1 Nectria haematococca
see fungal pages for sequence
CYP5232A1 Puccinia graminis f. sp. Tritici
very poor match to other sequences
seems long in the middle region
see fungal pages for sequence
CYP5233A1 Puccinia graminis f. sp. Tritici
35% to CYP63A2 Phanerochaete chrysosporium
see fungal pages for sequence
CYP5234A1 Uncinocarpus reesii
32% to CYP577A3 Nectria haematococca
see fungal pages for sequence
CYP5234A2 Coccidioides immitis
69% to CYP5234A1
see fungal pages for sequence
CYP5234B1 Histoplasma capsulatum G217B
ABBT01000117.1 Ajellomyces capsulatus G217B
45% to CYP5234A1
see fungal pages for sequence
CYP5235A1 Uncinocarpus reesii
39% to CYP570A1, 37% to CYP570B1, 34% to CYP570F1
see fungal pages for sequence
CYP5235A2 Coccidioides immitis
74% to CYP5235A1 Uncinocarpus reesii
see fungal pages for sequence
CYP5235A3P Aspergillus clavatus
AKD03000007.1
mid region is 54% to CYP5235A2
see fungal pages for sequence
CYP5235A4 Neosartorya fischeri
59% to CYP5235A2
Note: this seq has no ortholog in A. fumigatus
see fungal pages for sequence
CYP5235A4 Aspergillus terreus NIH2624
AAJN01000135.1
93% to CYP5235A4 Neosartorya fischeri
see fungal pages for sequence
CYP5235A5 Metarhizium anisopliae var. anisopliae Ma23
CYP5236A1 Uncinocarpus reesii
36% to CYP625A1
see fungal pages for sequence
CYP5236A2 Coccidioides immitis
77% to CYP5236A1 Uncinocarpus reesii
see fungal pages for sequence
CYP5237A1 Uncinocarpus reesii
38% to CYP685A1, 31% to CYP613E1
see fungal pages for sequence
CYP5238A1 Uncinocarpus reesii
31% TO CYP559D1, MISSING C-TERM (ADDED BACK FROM GENOMIC SEQ)
32% TO CYP5195A1
see fungal pages for sequence
CYP5239A1 Uncinocarpus reesii
38% to 578C2
see fungal pages for sequence
CYP5240A1 Uncinocarpus reesii
28% to CYP639A1 Fusarium graminearum
see fungal pages for sequence
CYP5240A2 Coccidioides immitis
71% to CYP5240A1 Uncinocarpus reesii
see fungal pages for sequence
CYP5240B1 Histoplasma capsulatum G217B
40% to CYP5240A2 Coccidioides immitis
39% to CYP5240A1 Uncinocarpus reesii
ABBT01000077.1 Ajellomyces capsulatus G217B
see fungal pages for sequence
CYP5241A1 Coccidioides immitis
EST GH380914.1, GH380913.1
Very poor match to known P450s, only one intron
see fungal pages for sequence
CYP5241A1 Coccidioides posadasii Silveira
GH435524.1, GH435523.1 ESTs, ortholog to immitis seq
96% to CYP5241A1 Coccidioides immitis
see fungal pages for sequence
CYP5242A1 Coccidioides immitis
34% to CYP5237A1 Uncinocarpus reesii
EST GH381634.1, GH381633.1
see fungal pages for sequence
CYP5243A1 Coccidioides immitis
EST GH367762.1
31% to CYP590A1 Magnaporthe grisea
see fungal pages for sequence
CYP5244A1 Coccidioides immitis
37% to CYP596A1
see fungal pages for sequence
CYP5245A1 Histoplasma capsulatum H88
Supercontig 1: 6824213-6826226 -
ABRJ01000082.1 Ajellomyces capsulatus H88 118177-116161
see fungal pages for sequence
CYP5245A1 Histoplasma capsulatum H143
Supercontig 2: 2329560- 2331651 +
see fungal pages for sequence
CYP5245A1 Histoplasma capsulatum G186AR
Supercontig 3: 1482810-1484825 -
42% to 623B2, 35% to 623A1\
see fungal pages for sequence
CYP5245A1 Histoplasma capsulatum Nam1
Supercontig 5: 1478881-1480888 +
C-term has many frameshifts
see fungal pages for sequence
CYP5246A1P Histoplasma capsulatum G217B
ABBT01000025.1 Ajellomyces capsulatus G217B
see fungal pages for sequence
CYP5246A1P Histoplasma capsulatum G217B
ABBT01000049.1 Ajellomyces capsulatus G217B
XM_001935421.1
The downstream PORTION OF THIS FUSION PROTEIN
resembles siroheme synthase
35% to CYP5049A1
see fungal pages for sequence
CYP5247A1P Histoplasma capsulatum G217B
38% to CYP587B4 Aspergillus terreus
see fungal pages for sequence
CYP5248A1P Histoplasma capsulatum G217B
31% to CYP660A2
see fungal pages for sequence
CYP5249A1P Histoplasma capsulatum G217B
36% to CYP5183A1 A. niger
see fungal pages for sequence
CYP5250A1 Histoplasma capsulatum G217B
ABBT01000198.1 Ajellomyces capsulatus G217B
37% to CYP582A1 Magnaporthe grisea
see fungal pages for sequence
CYP5251A1 Kluyveromyces lactis
29% to CYP613B1
see fungal pages for sequence
CYP5252A1 Kluyveromyces lactis
28% to CYP578G1 (only a partial seq)
see fungal pages for sequence
CYP5253A1 Mimivirus
called Cyp51 by David Lamb, best hits are CYP51 but only at 23%
one of only two viral P450s
1 MLFELSIGAI IGFLTLYLLK RFNESKNFIT PDNLKKIPIV EGAVPVLGHG PAFSKDIMQF
61 MKNCYKKYGS VFQLKIFRTN MVVLCDRKLS EEFFKSREND MSLYDVLNRL FFGLAFSDKP
121 DSLEFIIKMV KKTITIRYDD FAPKIMDEAQ RLTKIMRESH SGKKLDMIPE IIKFVSRTSA
181 RCFIAMDIDD EFYDALNKFT NLLNKIVVLT YFVPHWLLNA TLNRFMLRKY RMRMTKLLEN
241 EIEKYRTDLN KSDSLLFRKC VDHIDPETGA TLTNQDIGDI VVCLLYVSSE NTSLLATNCL
301 IDLTLNPKYW DLIKSECSAM IALGDYKNLF KAPLLNSIVM ESARLNSHVF ALARKPKTVN
361 RIGDYFVADN VDTISLCEPA LMKFEIASDV YANPNSYDPV RFMAPRNEPK DSGHVMNWGK
421 GVHECPGKQF AIYEVKAAIA YIVTNFERFE FNHNDLKINY FSPSAMCEKN ISVEFIPSQQ
481 NIHNIVYKDR TYIVEHIKCN ETSAWLIYNA LDRQQQREYY QYTYEISTDS QEHKLIEKAG
541 PHKPFPIAYD KLVYTGQSNC MTPTKWYDFA SDIWELLTEN YAELGFPIYD DKIRNFVPNS
601 FYGQLYSVES IMPTHRDQHV DYGLSISIGS NCEFVIEDKT ILLPSGSVLI GDFSKISHSV
661 SKIFHEKPDH LSDFEFFNRV RFSAQIRSID PDVQPLMTTQ EFLDMISEY
CYP5254A1 Mimivirus
one of only two viral P450s
1 MVLSDILFSI YEHREKSPVF SWFAYLLRIL DWIIQFLSFG LIPSIGGDLY DLVDNGLFKF
61 VLDRNIQKKQ NQLYDKFRLG TVKMCLVFDG ELTKKLLLDN SIRRGGLYNL LTKFFGKGIF
121 TSNIHSRWMK QRKAIFKLFS PQNLIQITPE LTTSMFEELD RLITIKKDLD LVTVLSLIGL
181 VGFCKVIFGV DVTDMSEELI EPLNDLLIYI NGAVEPVLIT ADPSYRRFIT NKKFVHNWMR
241 KLIDKARKSE NCFEIMRQQL DDIGSDDETE LIEFILSVVL GGHETTARLM LGIIYSVCHN
301 KEIIEKLNNE TDEYPKGDYI NLKKRPYLNN IIKEGTRLFP PVWLLSREAK NDTTIDNHFF
361 KKGTQFLISP LIILRDYNVW GSNAEKFDPE RFSNMDPKSK ASKLYIPFIV GSEDCPGKKF
421 AILESAIVVS KLFKEYEITV LKHKLNPMSA GTFRLSDKLP VSIKKLKN
CYP5255A1 Fusarium oxysporum
30% to CYP606B1
see fungal pages for sequence
CYP5255A1 Fusarium verticilloides (temp 5255A2)
Supercontig 2: 646261-647922 (-) strand
87% to CYP5255A1
see fungal pages for sequence
CYP5256A1 Fusarium oxysporum
31% to CYP65AU1 Coccidioides immitis
see fungal pages for sequence
CYP5256A2 Talaromyces stipitatus ATCC 10500
ABAS01000009.1
66% to CYP5256A1 Fusarium oxysporum
see fungal pages for sequence
CYP5257A1 Fusarium oxysporum
EST CK615609.1
34% to CYP627A2 Fusarium sporotrichioides
see fungal pages for sequence
CYP5258A1 Fusarium oxysporum
35% to CYP65AB1, 37% to CYP562A1
see fungal pages for sequence
CYP5258B1 Verticillium dahliae VdLs.17
ABJE01000519.1
44% to CYP5258A1, 42% to CYP562A1 Magnaporthe grisea
45572 MEVKYVSSTEGPSSTTTLPWVPVAGVIAGT (0)
45428 VVLYVILTGVYNIWFHPLRAYPGPWWLVANRLPYTLSVLRGTATRRAKALHEQYGHVVRI 45249
45248 NPDTLSFTSGEAWR (1)
45138 DIYGSQSRCNPGIPKDPYFYMQHQGPANI (0)
STLNDDDHHRLRRV 44962
44961 QLNAFSPKALASHEVHVRRHASGLVSQLRSSADAKTDVDMFLRLELLVTDIISKLVLG 44788
44787 ESFCLLEKDDPQPGHFGVFSVLRNHTYAREMMHWPSIFRRAVVRFMTKRPATPNQTM 44617
44616 WMTRKATQKRFQQEGDEYDYISCMQRGSPKLR (2)
MSEDEI 44437
44436 RVSTTAFVIAGSET (1)
TATAIAATMYLLCKNPRVYSAL 44257
44256 THSIRSDFPLESDMTMPRLVQHEQLNNVLQEALRLYPPVPDNLFRRTADNASLVMGKVLP 44077
44076 PDTSVTMNVWAANTSALNFHRPDEMLPDRWSSSRPKEFEGDDRGVFNPFGVGPKDCLGKG (2) 43897
43832 LAWMEMRIVVAYLVWHFQFELTPESEAWMDGQKVFMFWEKPPLRVKVMKR* 43680
CYP5259A1 Fusarium oxysporum
36% to CYP530A11, most similar to pseudogene CYP530A6P, 52% to C-term
see fungal pages for sequence
CYP5259A1 Fusarium verticilloides
Supercontig 14: 11152-13123 (-) strand
92% to CYP5259A1 = ortholog
see fungal pages for sequence
CYP5260A1 Fusarium oxysporum
33% to CYP5095A1 Aspergillus oryzae, 34% to 682D3 Uncinocarpus reesii
see fungal pages for sequence
CYP5260A1 Fusarium verticilloides
Supercontig 15: 1333668-1335368 (+) strand
91% to CYP5260A1 = ortholog
see fungal pages for sequence
CYP5261A1 Fusarium oxysporum
35% to CYP630D1 Aspergillus oryzae
see fungal pages for sequence
CYP5261A1 Fusarium verticilloides
Supercontig 11: 1036601-1038275 (+) strand
86% to CYP5261A1 = ortholog
see fungal pages for sequence
CYP5262A1 Fusarium oxysporum
34% to CYP625A1 Fusarium graminearum
see fungal pages for sequence
CYP5262A1 Fusarium verticilloides
Supercontig 18: 139667-141223 (-) strand
86% to CYP5262A1, no introns, probable ortholog
see fungal pages for sequence
CYP5262A2 Fusarium verticilloides
63% to CYP5262A1 Fusarium verticilloides
not found in the F. oxysporum genome
see fungal pages for sequence
CYP5262A3 Neosartorya fischeri
56% to CYP5262A2 Fusarium verticilloides
Note: this seq does not have an ortholog in A. fumigatus
see fungal pages for sequence
CYP5262A4 Metarhizium anisopliae var. acridum Ma102
CYP5262A4 Metarhizium anisopliae var. anisopliae Ma23
CYP5263A1P Fusarium oxysporum
45% to CYP639A3, 41% to CYP5100A1 Aspergillus flavus
C-term pseudogene fragment, no upstream P450 sequence is found
see fungal pages for sequence
CYP5263A2 Botryotinia fuckeliana B05.10
XM_001549031
47% to CYP5263A1P in C-term part only
weakly similar to CYP639 family mainly in the C-term part
MKLLDNLYLYEGWKAMAFSACLLPFLVSYLVTTIKSVIAVRSKN
NDKSPAIDPSADFIFGNLLAFSFDTRGYMAHLIERFGPHVPVRIRVASDSFYFVSGPE
YILKLFRGSRDLTAIPAMAAIVERIFGAPPEASSVLLDDNTGTSPKPLLDSNPLPGDQ
RYHHISHHAYTDNLTGVRLAEVVARFLTNLGTELDKIGVVGGPLKGIPRFFIPDAYRI
RDKMVKSILEWHRSAEAHLDHSDKELDKTSWEPYYGSRLFRNRARHLSKINGFGDQAR
AANDLGLIWGANSNSIPAIAWCILDIICRPDLLSQVQAELASIEKLHPTANFDQRMPD
LLSNLLLQSIYCEELRLRNAAALQRSTVSSNFKLGPWKFPKEAMILASIWFAGHDKNV
WNEGANGEHDVDSFWPERFILYPNNPYSGPRKSDSGKHPSEKIAKPKLTTDTVSGSWI
PYGGGQQICPGRFYAKQESIGSIAMFLSKFEIELTGNKNPEPDFKYFSLGVLPPKGKF
PARLRRRLGKVAE*
CYP5264A1P Fusarium oxysporum
36% to CYP633A1 Fusarium graminearum
note CYP561E1 is about 3000bp downstream
PERF in green, no heme signature, probable pseudogene
see fungal pages for sequence
CYP5265A1 Fusarium oxysporum
39% to CYP609A1 Magnaporthe grisea,
39% to CYP5193A1 Mycosphaerella graminicola
see fungal pages for sequence
CYP5266A1 Fusarium oxysporum
no gene model
Supercontig 19: 668959-670705 (-) strand, frameshift
see fungal pages for sequence
CYP5266A1 Fusarium verticillioides
28% to CYP5195A1 Mycosphaerella graminicola
Supercontig 19: 108020-109773 (+) strand, & = frameshifts
97% to CYP5266A1 Fusarium oxysporum = ortholog
see fungal pages for sequence
CYP5266A1 Gibberella moniliformis 7600 chromosome 4
AAIM02000163.1 EST DR645966.1 Gibberella moniliformis
97% to CYP5266A1 Fusarium oxysporum = ortholog
see fungal pages for sequence
CYP5266B1 Penicillium marneffei ATCC 18224
XM_002149609
48% to CYP5266A1 Gibberella moniliformis
this genbank predicted mRNA seq has a missing region at the EXXR motif
due to a frameshift and removal of an intron that is incorrect
MAEGYTQIFQSGPLLMVMASLITGLAWLFYLIQPALLASFSAKY
GSFRWVDGSPGFLEFIELSCKCVFHAGELFTVAYKLLKTANGLLLIPFPHSPTGFLLL
LPKELIAEYARQPESIVSFHTYVRNAMHAKYSLFGDNVLDNNIQKPIVYRELFQKLPD
KMDMMNEELVMAINDGVTANLDSHGEISINMWDTATAILSRASNRIIAGHPLCRNQEY
LDAAVHYAVSMFSLAVYLRFIPPFLRPLLASLVRRPLSRDRDIVAKHAIPVIEERMKM
IEEAEIKGVEPKLPNDLLSAALKVARKDSNSKLEYTPMMMVNRILAFNFLQSYSNTLT
VTNAVYDLTSLPQAEFDRTVTDTRAELSWELRRPNAWSHDFVN &
MDSFIRESLRANPIGEVELERTIT
SKDGFTFSNGLHVPHGAILAAPLKAIQQDPANYPGGFNPRRASEDLIRPTVTTITPVF
LNFGLGRPACPGRWFAVNMQKLTLSHLLLEYDFQRVDARPPGVRKGTLVEPCGRSKIT
LKRRIVVDQ*
CYP5266B2 Talaromyces stipitatus ATCC 10500
ABAS01000014.1
81% to CYP5266B1, 50% to CYP5266A1 Fusarium oxysporum
513492 MEEKHIQIFQSA
513504 PLLIGLAALTTVLAWFFHLIKPALLATFSRKYSSFKWVEERRGFFGFIRLSYKCVFHAKE 513683
513684 LFTVAYEK (0) 513707
513766 LRNTASEVF
513793 LVPFPHSSTGFLLLLPKELIAEFARQPESIISFHTYVRNAMHAQYSLFGDNVLDNNIQKP 513972
513973 IVYRELYQKLPDKMQMMNEELVLAIKDVLDAKLNEKGEISINMWDTATAILSRASNRIIA 514152
514153 GDPLCRNQEYLDAAVHYAISMFSLAVYLRFIPPFLRP (2)
514315 LLAPLV 514332
514333 RRPLSRDRDIVAKHAIPVIEERMKMIEDAEIKGNKPKVP (0) 514449
514521 NDLLSAALKVARKDPNSKLEYTPMMMVNRLLAFNFLQSYSNTLTMTNAVYDLISLPPEEF 5147
514701 ERTVTDIREELTRELKRPDAWSHDFVNRLVVMDSFIRESLRANPIGEVGLERIVTRENGF 514880
514881 TFSNGLHVPRGAIIAAPLKAIQQDSANYPGGFNPRRALEDPTHPTVTTISPVFLNFGLGR 515060
515061 PACPGRWFAVNMQKLALGHLLLEYDFQRVEVRPLGVRKVTLVEPCERSKIVLRRRSVG* 515237
CYP5266B3 Ajellomyces dermatitidis ER-3 cont1.288
ACBT01000288.1
64% to CYP5266B1 Penicillium marneffei, N-term not clear
447023 IAGWLSQPWHVFLLQAVAGTFLITFAACLVHLLEPALLASFSPKYDGFTWVTGERGLGNF 447202
447203 FSVAYDCVFDAGSLFKVAYQK (0) 447265
VRNTGSE
447352 IFLTPFPHSNTGFMMLLPRQFIAEYARQPEAIVSFNKYVRDVMHPKYSLFGANILDNNLQ 447531
447532 KPIVYRELYQKLGNKIEMMSTELVGALNDVLLPQLDENGEMKINMWDTATKFLSRTSNRI 447711
447712 ISGYPLCRNQD & 447744
447744 YLDATVHYAVNMFSRAVYIRFIPRFLRP (2)
LLAPLVRRSLSRD 447923
447924 RKIVAKHAVPIIKERMRILETAEGKGIEADLP (0) 448019
448072 NDLLSQAIVAARREKHSYIEYDPMQIVSRLLAFNFLQSYSNTLIMTNCIYDLISLPKG 448257
448258 VFEETVADLCEEINRELAKGDPWSYDYIKRLDVMDSFIRKSLRANPIGEVGLERTIMSKE 448437
448438 GFTFSNGLHVPQGTTLAAPLKAIQRDKDNYPSGFDPKRSLRDPAKPKITTSSPEFLNFGL 448617
448618 GHPACPGRWFAASLQKLAFSHLLLEYDFVRVDQRPPGVRKVTLVEPCGRSLITLRKRKAT* 448800
CYP5267A1 Fusarium verticillioides, Gibberella moniliformis
33% to CYP596B1 Nectria haematococca
not in F. oxysporum genome
see fungal pages for sequence
CYP5268A1P Fusarium verticillioides
38% to CYP592A1 Magnaporthe grisea, pseudogene not
found in F. oxysporum
see fungal pages for sequence
CYP5268A2 Aspergillus terreus
69% to CYP5268A1P
see fungal pages for sequence
CYP5269A1 Fusarium verticillioides
37% to CYP53A15 Cochliobolus lunatus, not found in F. oxysporum
see fungal pages for sequence
CYP5269A2 Aspergillus terreus NIH2624
XM_001213125.1
60% to CYP5269A1 Fusarium verticillioides
see fungal pages for sequence
CYP5269A3 Grosmannia clavigera
CYP5269B1 Grosmannia clavigera
CYP5270A1P Fusarium oxysporum
Supercontig 8: 131065-131663 (-) strand
No gene model, 85% to CYP5270A1 Fusarium verticillioides
see fungal pages for sequence
CYP5270A1 Fusarium verticillioides
only 32% to CYP684B1 Nectria haematococca
see fungal pages for sequence
CYP5271A1 Fusarium verticillioides
only 30% to CYP511A1 Botrytis cinerea,
not found in the F. oxysporum genome
see fungal pages for sequence
CYP5271A2 Fusarium verticillioides
54% to CYP5271A1 Fusarium verticillioides
not found in the F. oxysporum genome
see fungal pages for sequence
CYP5272A1 Aspergillus clavatus
32% to CYP526G1 Fusarium verticilloides
see fungal pages for sequence
CYP5272A2 Microsporum canis CBS 113480
ABVF01000250.1
84% to CYP5272A1
24684 MDILSLNYQLSIGIGLLAFILYFGFKRAYPRPYPGIPYNVASARKIWGDSTGLLEDIKIT 24863
24864 QDPAKYIFHQSRNLGSPVIQMFLAPFSNPTIVIDDVREVKDILSNRTLEFDRARRTQDAY 25043
25044 RSLLPHCSLVKLTGPAFKNQRRFWEGVTGTPFLRRVAEPKMYRCALGLIDLLRAQAKMAG 25223
25224 GRPFYCFDGFDVAAFELIWELVFGTKVDGIKGALSKVLSVTSDTVQPPSIDSAAQIPVIQ 25403
25404 KPDMCEAVSFFISTVAKSLQSVVSQKWSLWYLRQQPVYKRKLAFKESTIDGLIEATRAKL 25583
25584 AGLSADQLMEVEETSAVVTGVRRQLLAQMRQGQPINVPFPALIQAEIHDELFMILVA () 25754
25823 GHETKAVLLSWAVKFLIANPGKQEKLRKALVDALPKGSNGEQPSSKAIMSTSIPYLEAYM 26002
26003 EESMRAANTSPRLVRRTTTDTQVLGYPIPKGVTVLLNPYVGTKPLDIPEHMRSETCRGSK 26182
26183 DNFESYWDINGMDEFHPERWLSEDGSFNLRKFPRLGFSAGPRMCY () 26320
26415 GRNLALMEFRLNLVLLVLNFKFEPLPKGLDSMESQQRLFRMPRQCYVRLSPL* 26573
CYP5272B1 Neurospora discreta
JGI gene model estExt_Genewise1Plus.C_21110, removed two sequences
41% to CYP5272A1 Aspergillus clavatus
See fungal pages for seq
CYP5272C1 Metarhizium anisopliae var. acridum Ma102
CYP5272C1 Metarhizium anisopliae var. anisopliae Ma23
CYP5273A1 Aspergillus clavatus
34% to CYP531D2
see fungal pages for sequence
CYP5274A1P Aspergillus clavatus
pseudogene
25% to CYP639A3 Fusarium oxysporum
(+) strand
see fungal pages for sequence
CYP5275A1P Aspergillus clavatus
50% to CYP5100A2 A. niger
no gene model but adjacent to CYP5274A1P on opposite strand
only 33% to CYP5274A1P Aspergillus clavatus
(-) strand
RLCPGRHFAKRKMILTADIMVTLFDGEILADVRTLRMDMRGFGFGTLGVDGPVPVRIRRRKINE*
CYP5276A1 Aspergillus clavatus
31% to CYP503B1 Aspergillus nidulans
possible gc boundary at KVWPF, N-term region not well supported
see fungal pages for sequence
CYP5277A1 Aspergillus clavatus
35% to CYP5068B1
see fungal pages for sequence
CYP5278A1 Neosartorya fischeri, Aspergillus fischeri
AAKE03000027.1
33% to CYP636A1, 76% to CYP5278A2
Note: this seq does not have an ortholog in A. fumigatus
see fungal pages for sequence
CYP5278A2 Penicillium chrysogenum Wisconsin 54-1255
AM920436
76% to CYP5278A1
MNLIPLLVLSIILYGVLRLLEVRKCKITTSEPPIVYSRIPIVGHALGLFRYGVSYYRML
REQTNLPILTVFLGLQKVYVVTSPALISQINRRQKVIDSNPPFLTVVMGKLFSFH
KNDLAELLRNPNETGSLRRDTRTAEHSLLERGAAPLLEIFTGMMQEMVIQLNTLASN
GPVTIRLEGWLRETITMCTAKAVFGPNNPFAQDPSLMQDFWVFESGLKGLTMGIFPE
LTASGPARARRRLVQAFHRFVQGEFIARGETCELLRQVEDIAHQHNRGSDYLARYYL
GIFSAFLLNTVPVTFWTISHILQRADLLARIRTELDDVARESVSTNGIRKRYLDVAS
IRERCPLFLSTFQEILRYVGASTSTLLVHDDVWLDGTYLLTKGSLVQIPATAIHSDP
KIWGPDATTFDPERFLKAAPNQVHPSASRTFGGGGTLCPGRHLASDEVLEVTALFLS
TFKVGFEAESGRPRRDETGMLSAIKPKDDLLLRLTRYPAMGNVVWGA
CYP5279A1P Neosartorya fischeri, Aspergillus fischeri
C-term pseudogene fragment, the sequence immediately upstream has \
strong similarity to C-3 hydroxysteroid dehydrogenase. This suggests a
sterol biosynthetic gene cluster that has degraded.
Note: this seq has no ortholog in A. fumigatus
see fungal pages for sequence
CYP5280A1P Neosartorya fischeri
most like CYP630 (33-39%), 37% to CYP630D4 Neosartorya fischeri
one stop codon, possible pseudogene
Note: this seq has no ortholog in A. fumigatus
see fungal pages for sequence
CYP5281A1 Neosartorya fischeri
39% to CYP68L3, 38% to CYP5067A2,
93% to CYP5281A1 Aspergillus fumigatus = ortholog
see fungal pages for sequence
CYP5281A1 Aspergillus fumigatus Af293
AAHF01000006.1
93% to CYP5281A1 = ortholog, 40% to CYP5067A2
Part of a toxin biosynthesis cluster with another
P450 CYP5074A1 and a PKS
see fungal pages for sequence
CYP5282A1 Neosartorya fischeri
49% to CYP5282B1 Talaromyces stipitatus
30% to CYP609A1 Magnaporthe grisea
note: this seq. has no ortholog in Aspergillus fumigatus
see fungal pages for sequence
CYP5282B1 Talaromyces stipitatus ATCC 10500
ABAS01000032.1
49% to CYP5281A1
196721 MDFNAQNFQSPVTISLAGLLATLISLLAYMSYSPPIDKRSPAFTSDTVPFIGSWRFFTQKL (2) 196873
196929 PFWRNSMALSKTGNFSFWLGKNHVVGVSGEASRKMYLESRSLHLIKGITLIGHGPDFIDGR 197111
197112 STVIHNIWKSAYTNDRTYATRRLLDLQKSEHLVKRLPRVTRDARLAFEEMPNNATGVM 197285
197286 NPTKVCYRLVVMQGSRLICSNEIADDPQQLNRLVRYVSTLQSTSSLHLLAFPWLSYFSVS 197465
197466 YWKRRWGRNGITQIVKPIVNRRMRKGAPRFDDSLQFLIESGDSKDYITNFLISMLFIVAA 197645
197646 NAGVLSGAMLNIVAHHPKWQEKIYDEIKAAAAIHSKNSNAPLVDQLDSIPLGAWETSFPS 197825
197826 IDLCYKEAIRMWVAFPMGRFNDTHSPIPIPGTNEVIPPGSFACYNTLDVHYNEKLYPDPM 198005
198006 KWDPERFLERREEYKKEAYG (1) 198065
198151 YMGWGAGRHPCTGMRWAKLQQNIILAYALALYKWSGCDEHGDPNPHFAQPTTALNELAPRL 198333
198334 PQGLWCKYVPRENV* 198378
CYP5282B2 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_70410
56% to CYP5282B1 Talaromyces stipitatus
see fungal pages for sequence
CYP5282B3 Metarhizium anisopliae var. anisopliae Ma23
CYP5282C1 Penicillium marneffei ATCC 18224
ABAR01000002.1
49% to CYP5282B1, 44% to CYP5282A1
MTMNVTLPTRM
1300609 VSLDPEFYQSPVTIGLGTILAAILSLFAFVSYTPRVDKRVPKFTSDTYPFIGAANFMWRKG (2) 1300427
1300366 QFLKDSFKESKTGHFSFWVGKKHVVGVSGEAGRKAFLEGP 1300250
1300249 GLDFVQGSGLRGVGLRKLTPIPEIFKPNFHNGRSYFLRRLIDMQKSEVLRNHLARL 1300082
1300081 TSDTRKIFQSALAKDTTGVTNPAITCARIVYTHDMLLFCCQEIADDTKIFEELFEMYNTM 1299902
1299901 QAASSFKAVFFPWIPSTDTRKRAERLKYLQDLFDPVVDRRMRGITPRQEDGLQFMIDS 1299728
1299727 GDKKANIADFFVSIIFIAPTNSRILMGQMLHNMASHQEWQEKVHAEIKAAAKAHAKNPNA 1299548
1299547 PLVEQLDSLPLDVWETSFPTLDICFKEAIRMWVVFSMMRKNIGSTPIELPGSNEVIPAGS 1299368
1299367 YAIYNTAEIHLNPELYPEPTKYKPERWLPGNDYYKKVTYG (1) 1299248
1299183 FLGWGDGRHPCPGKRWAKLQSTITVAYALAGWKWMSIDD 1299067
GIANKSSSDGGHGTVLSGKLLKFVSRDE*
CYP5282D1 Grosmannia clavigera
CYP5283A1P Aspergillus fumigatus
Supercontig 3: 828806-829117 (+)
~68% to CYP5283A1 Neosartorya fischeri at the N-term
probable ortholog to CYP5283A1 Neosartorya fischeri in rapid decay
see fungal pages for sequence
CYP5283A1 Neosartorya fischeri
35% to CYP5074A1
see fungal pages for sequence
CYP5284A1P Aspergillus oryzae
Supercontig 20: 496256-497391 (-)
97% to CYP5284A1 Aspergillus flavus
see fungal pages for sequence
CYP5284A1 Aspergillus flavus
31% to CYP5157A1, similar to N-term of CYP608A2
see fungal pages for sequence
CYP5285A1 Aspergillus oryzae
GenEMBL BAE56589.1
98% to CYP-un2 Aspergillus flavus
begins supercontig_5 61728-63540 (-) strand
213 bp from CYP65AB1 head to head arrangement
formerly CYP-un2
see fungal pages for sequence
CYP5285A1 Aspergillus flavus NRRL3357
GenEMBL AAIH01000268.1
98% to CYP-un2 Aspergillus oryzae
Supercontig 8: 71207-73019 (-) strand,
216 bp from CYP65AB1 head to head arrangement
formerly CYP-un2, suspected gc boundary at SSFQ
see fungal pages for sequence
CYP5285A2 Aspergillus clavatus NRRL 1
GenEMBL AAKD02000041.1
pseudogene, 70% to CYP5285A1, 33% to 654A1, 28% to 503A1
Supercontig 80: 639186-639335 -
formerly CYP-un3
see fungal pages for sequence
CYP5286A1 Aspergillus oryzae
EST EY428112.1 N-term
98% to CYP5286A1 Aspergillus flavus
see fungal pages for sequence
CYP5286A1 Aspergillus flavus
EST CO136609 confirms the C-term
40% to CYP685A2, 42% to CYP5237A1
98% to CYP5286A1 Aspergillus oryzae
see fungal pages for sequence
CYP5287A1 Aspergillus flavus
33% to 617D8
Note: there is no ortholog of this gene in A. oryzae
see fungal pages for sequence
CYP5288A1 Aspergillus flavus
38% to CYP52G6 Aspergillus niger
Missing N-term (about 8 aa) in a seq gap
note: there is no ortholog of this gene in A. oryzae
see fungal pages for sequence
CYP5289A1 Aspergillus oryzae
Supercontig 13: 1279061-1280977 (-) strand
see fungal pages for sequence
CYP5289A1 Aspergillus flavus
34% to CYP5110A1 Aspergillus oryzae
93% to CYP5289A1 Aspergillus oryzae
see fungal pages for sequence
CYP5290A1 Aspergillus terreus
33% to CYP5055A1 Nectria haematococca
Note: does not match any other Aspergillus P450 at the family level
see fungal pages for sequence
CYP5291A1 Aspergillus terreus
37% to CYP512G2
see fungal pages for sequence
CYP5292A1 Aspergillus terreus
35% to CYP58M2
see fungal pages for sequence
CYP5292B1 Metarhizium anisopliae var. anisopliae Ma23
CYP5293A1 Aspergillus terreus
42% to CYP5286A1 Aspergillus flavus
43% to CYP5237A1 Uncinocarpus reesii
41% to CYP685A2 Neosartorya fischeri
see fungal pages for sequence
CYP5293A2 Aspergillus terreus
62% to CYP5293A1 Aspergillus terreus
see fungal pages for sequence
CYP5294A1 Aspergillus terreus
34% to CYP5068B1
see fungal pages for sequence
CYP5295A1 Aspergillus terreus
41% to CYP5069A1 Neosartorya fischeri
42% to CYP5050A1 Nectria haematococca
see fungal pages for sequence
CYP5296A1 Aspergillus terreus
35% to CYP5049A1 Nectria haematococca
see fungal pages for sequence
CYP5297A1 Aspergillus terreus
see fungal pages for sequence
CYP5298A1 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_30530
34% to CYP596A1 Magnaporthe grisea
see fungal pages for sequence
CYP5298B1 Mycosphaerella fijiensis
JGI gene model gw1.3.810.1
38% TO CYP5298A1 Mycosphaerella fijiensis
36% TO CYP596B1 Nectria haematococca
see fungal pages for sequence
CYP5299A1 Mycosphaerella fijiensis
JGI gene model e_gw1.6.409.1
31% to CYP5107A1 Aspergillus flavus
see fungal pages for sequence
CYP5299A2P Mycosphaerella graminicola
JGI gene model e_gw.7.555.1
45% to CYP5299A1 Mycosphaerella fijiensis
see fungal pages for sequence
CYP5300A1 Mycosphaerella fijiensis
JGI gene model e_gw1.2.689.1
37% to CYP68L6 Aspergillus terreus
36% to CYP68D1 N. crassa
see fungal pages for sequence
CYP5301A1 Mycosphaerella fijiensis
JGI gene model estExt_fgenesh1_pg.C_130049
38% to CYP5265A1 Fusarium oxysporum
33% to CYP609A1 Magnaporthe grisea
see fungal pages for sequence
CYP5301A2P Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_71000004 revised
46% to CYP5301A1 Mycosphaerella fijiensis
see fungal pages for sequence
CYP5302A1 Mycosphaerella fijiensis
JGI gene model e_gw1.13.371.1
32% to CYP611A2 Uncinocarpus reesii
see fungal pages for sequence
CYP5303A1 Mycosphaerella fijiensis
JGI gene model fgenesh1_pm.C_scaffold_9000099
36% to CYP5128B1 Phaeosphaeria nodorum
see fungal pages for sequence
CYP5304A1 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1Plus.C_210305
31% to CYP5104B1 Aspergillus niger
see fungal pages for sequence
CYP5305A1P Mycosphaerella fijiensis
JGI gene model e_gw1.29.27.1
40% to CYP5243A1 Coccidioides immitis
seq. is short where the XXX are but there is no intron seq there so the
length cannot be made any longer. I suspect this may be a pseudogene.
see fungal pages for sequence
CYP5306A1 Mycosphaerella fijiensis
JGI gene model gw1.9.152.1 revised at N-term
32% to CYP52G2 Aspergillus fumigatus
see fungal pages for sequence
CYP5307A1 Mycosphaerella fijiensis
35% to CYP583A1 Magnaporthe grisea
JGI gene model fgenesh1_pm.C_scaffold_1000175
see fungal pages for sequence
CYP5308A1 Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_9000171
33% to CYP504A13
see fungal pages for sequence
CYP5309A1 Mycosphaerella fijiensis
JGI gene model synt_with_mycgr.5__2
note: EXXR (ECIR) and PERF (PARW) motifs are
present but no heme Cys is found
gene model has long C-term, probably incorrectly fused two genes
seems to be missing some seq where the XXX are shown
see fungal pages for sequence
CYP5310A1P Mycosphaerella fijiensis
JGI gene model fgenesh1_pg.C_scaffold_1001253
28% TO CYP642A2, 28% TO CYP660B1
see fungal pages for sequence
CYP5311A1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.33__108
35% to CYP5213A1 Rhizopus oryzae
see fungal pages for sequence
CYP5311A2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.45__88
81% to CYP5311A1
see fungal pages for sequence
CYP5311A3 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model e_gw1.10.197.1
55% to CYP5311A1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5312A1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_150247
28% to CYP5311A1 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5313A1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.2__19 revised with gc boundary after PLLNN
55% to CYP5313A2 Phycomyces blakesleeanus
33% to CYP576A3 Aspergillus terreus
see fungal pages for sequence
CYP5313A2 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.5__74\
56% to CYP5313A3 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5313A3 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.14__210
56% to CYP5313A2 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5313A4 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model fgeneshPB_pg.2__20
55% to CYP5313A2 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5313B1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_50177
46% to CYP5313A2 Phycomyces blakesleeanus
see fungal pages for sequence
CYP5314A1 Phycomyces blakesleeanus (Zygomycete fungus, Mucoromycotina)
JGI gene model estExt_fgeneshPB_pg.C_130264
29% to CYP530A11 Fusarium oxysporum
see fungal pages for sequence
CYP5315A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5316A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5317A1 Metarhizium anisopliae var. acridum Ma102
CYP5317A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5318A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5319A1 Metarhizium anisopliae var. acridum Ma102
CYP5320A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5321A1 Metarhizium anisopliae var. acridum Ma102
CYP5321A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5322A1 Metarhizium anisopliae var. acridum Ma102
CYP5323A1 Metarhizium anisopliae var. acridum Ma102
CYP5323A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5324A1 Metarhizium anisopliae var. acridum Ma102
CYP5325A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5326A1 Metarhizium anisopliae var. acridum Ma102
CYP5327A1 Metarhizium anisopliae var. acridum Ma102
CYP5327B1 Metarhizium anisopliae var. anisopliae Ma23
CYP5328A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5329A1 Metarhizium anisopliae var. acridum Ma102
CYP5329A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5329A2 Metarhizium anisopliae var. anisopliae Ma23
CYP5330A1 Metarhizium anisopliae var. acridum Ma102
CYP5330A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5331A1 Metarhizium anisopliae var. acridum Ma102
CYP5331A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5332A1 Metarhizium anisopliae var. acridum Ma102
CYP5333A1 Metarhizium anisopliae var. acridum Ma102
CYP5333A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5334A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5335A1 Metarhizium anisopliae var. acridum Ma102
CYP5335A1 Metarhizium anisopliae var. anisopliae Ma23
CYP5336A1 Metarhizium anisopliae var. anisopliae Ma23
CYP6001C17 Metarhizium anisopliae var. acridum Ma102
CYP6001C17 Metarhizium anisopliae var. anisopliae Ma23
CYP6002A7 Metarhizium anisopliae var. acridum Ma102
CYP6003A1 Metarhizium anisopliae var. acridum Ma102
CYP6003A1 Metarhizium anisopliae var. anisopliae Ma23
CYP6004A3 Metarhizium anisopliae var. anisopliae Ma23
CYP5337A1 Beauveria bassiana (an entomopathogenic fungus, Pezizomycotina)
No accession number
Nicolas Pedrini, Nemat O. Keyhani
Submitted to nomenclature committee Dec. 3, 2009
Clone name P450-3
36% TO CYP52G2 Aspergillus fumigatus
CYP5338A1 Grosmannia clavigera
CYP5339A1 Postia placenta (brown rot basidiomycete fungi)
CYP5339B1 Postia placenta (brown rot basidiomycete fungi)
CYP5340A1 Postia placenta (brown rot basidiomycete fungi)
CYP5340A2 confidential basidiomycete
CYP5340A3 confidential basidiomycete
CYP5341A1 Postia placenta (brown rot basidiomycete fungi)
CYP5341A2 Postia placenta (brown rot basidiomycete fungi)
CYP5341A3 confidential basidiomycete
CYP5341B1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5341B1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5341B2 confidential basidiomycete
CYP5342A1 Postia placenta (brown rot basidiomycete fungi)
CYP5343A1 Postia placenta (brown rot basidiomycete fungi)
CYP5344A1 Postia placenta (brown rot basidiomycete fungi)
CYP5341B1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5341B1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5344B2 Postia placenta (brown rot basidiomycete fungi)
CYP5345A1 Postia placenta (brown rot basidiomycete fungi)
CYP5346A1 Postia placenta (brown rot basidiomycete fungi)
CYP5347A1 Postia placenta (brown rot basidiomycete fungi)
CYP5347A2 confidential basidiomycete
CYP5347B1 Postia placenta (brown rot basidiomycete fungi)
CYP5348A1 Postia placenta (brown rot basidiomycete fungi)
CYP5348A2 Postia placenta (brown rot basidiomycete fungi)
CYP5348A3 Postia placenta (brown rot basidiomycete fungi)
CYP5348B1 Postia placenta (brown rot basidiomycete fungi)
CYP5348B2 Postia placenta (brown rot basidiomycete fungi)
CYP5348C1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348C1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348C2 Postia placenta (brown rot basidiomycete fungi)
CYP5348C3 Postia placenta (brown rot basidiomycete fungi)
CYP5348C4 Postia placenta (brown rot basidiomycete fungi)
CYP5348D1 Postia placenta (brown rot basidiomycete fungi)
CYP5348E1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348E1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348F1 Postia placenta (brown rot basidiomycete fungi)
CYP5348G1 Postia placenta (brown rot basidiomycete fungi)
CYP5348H1 Postia placenta (brown rot basidiomycete fungi)
CYP5348J1 Postia placenta (brown rot basidiomycete fungi)
CYP5348J2 Postia placenta (brown rot basidiomycete fungi)
CYP5348J3 Postia placenta (brown rot basidiomycete fungi)
CYP5348J4 Postia placenta (brown rot basidiomycete fungi)
CYP5348J5 Postia placenta (brown rot basidiomycete fungi)
CYP5348J6 Postia placenta (brown rot basidiomycete fungi)
CYP5348J7 Postia placenta (brown rot basidiomycete fungi)
CYP5348K1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348K1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348L1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348L1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348M1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348M1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348M1v3 Postia placenta (brown rot basidiomycete fungi)
CYP5348N1 Postia placenta (brown rot basidiomycete fungi)
CYP5348N2v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348N2v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348N3 Postia placenta (brown rot basidiomycete fungi)
CYP5348N4 confidential basidiomycete
CYP5348N5 confidential basidiomycete
CYP5348P1 Postia placenta (brown rot basidiomycete fungi)
CYP5348Q1 Postia placenta (brown rot basidiomycete fungi)
CYP5348Q2 Postia placenta (brown rot basidiomycete fungi)
CYP5348R1 Postia placenta (brown rot basidiomycete fungi)
CYP5348S1 Postia placenta (brown rot basidiomycete fungi)
CYP5348T1 Postia placenta (brown rot basidiomycete fungi)
CYP5348T2v1 Postia placenta (brown rot basidiomycete fungi)
CYP5348T2v2 Postia placenta (brown rot basidiomycete fungi)
CYP5348T3P Postia placenta (brown rot basidiomycete fungi)
CYP5348U1 confidential basidiomycete
CYP5349A1 Postia placenta (brown rot basidiomycete fungi)
CYP5349A2 Postia placenta (brown rot basidiomycete fungi)
CYP5349A3 confidential basidiomycete
CYP5350A1 Postia placenta (brown rot basidiomycete fungi)
CYP5350B1 Postia placenta (brown rot basidiomycete fungi)
CYP5350B2v1 Postia placenta (brown rot basidiomycete fungi)
CYP5350B2v2 Postia placenta (brown rot basidiomycete fungi)
CYP5350B3v1 Postia placenta (brown rot basidiomycete fungi)
CYP5350B3v2 Postia placenta (brown rot basidiomycete fungi)
CYP5350B4 Postia placenta (brown rot basidiomycete fungi)
CYP5350B5 Postia placenta (brown rot basidiomycete fungi)
CYP5350B6 Postia placenta (brown rot basidiomycete fungi)
CYP5350B7 Postia placenta (brown rot basidiomycete fungi)
CYP5350B8 Postia placenta (brown rot basidiomycete fungi)
CYP5350B9 Postia placenta (brown rot basidiomycete fungi)
CYP5350B10 Postia placenta (brown rot basidiomycete fungi)
CYP5351A1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5351A1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5351A3 confidential basidiomycete
CYP5352A1 Postia placenta (brown rot basidiomycete fungi)
CYP5353A1 Postia placenta (brown rot basidiomycete fungi)
CYP5354A1 Postia placenta (brown rot basidiomycete fungi)
CYP5354A2 Postia placenta (brown rot basidiomycete fungi)
CYP5355A1v1 Postia placenta (brown rot basidiomycete fungi)
CYP5355A1v2 Postia placenta (brown rot basidiomycete fungi)
CYP5356A1 Postia placenta (brown rot basidiomycete fungi)
CYP5357A1 confidential basidiomycete
CYP5357B1 confidential basidiomycete
CYP5358A1 confidential basidiomycete
CYP5359A1 confidential basidiomycete
CYP5359A2 confidential basidiomycete
CYP5359A3 confidential basidiomycete
CYP5359A4 confidential basidiomycete
CYP5359A5 confidential basidiomycete
CYP5359A6 confidential basidiomycete
CYP5359A7 confidential basidiomycete
CYP5359B1 confidential basidiomycete
CYP5359C1 confidential basidiomycete
CYP5359D1 confidential basidiomycete
CYP5359E1 confidential basidiomycete
CYP5359F1 confidential basidiomycete
CYP5359G1 confidential basidiomycete
CYP5359H1 confidential basidiomycete
CYP5359J1 confidential basidiomycete
CYP5359J2P confidential basidiomycete
CYP5359K1 confidential basidiomycete
CYP5359L1 confidential basidiomycete
CYP5359L2 confidential basidiomycete
CYP5359L3 confidential basidiomycete
CYP5359M1 confidential basidiomycete
CYP5359M2 confidential basidiomycete
CYP5359M3P confidential basidiomycete
CYP5359N1 confidential basidiomycete
CYP5359P1 confidential basidiomycete
CYP5359Q1 confidential basidiomycete
CYP5359R1 confidential basidiomycete
CYP5359S1 confidential basidiomycete
CYP5359T1 confidential basidiomycete
CYP5359T2P confidential basidiomycete
CYP5359U1 confidential basidiomycete
CYP5359U2 confidential basidiomycete
CYP5359U3 confidential basidiomycete
CYP5359U4 confidential basidiomycete
CYP5359V1 confidential basidiomycete
CYP5359V2 confidential basidiomycete
CYP5359V3 confidential basidiomycete
CYP5359W1 confidential basidiomycete
CYP5359W2 confidential basidiomycete
CYP5359X1 confidential basidiomycete
CYP5359Y1 confidential basidiomycete
CYP5359Y2 confidential basidiomycete
CYP5359Y3 confidential basidiomycete
CYP5359Y4 confidential basidiomycete
CYP5359Y5 confidential basidiomycete
CYP5359Y6P confidential basidiomycete
CYP5359Z1 confidential basidiomycete
CYP5359Z2 confidential basidiomycete
CYP5359Z3 confidential basidiomycete
CYP5359Z4P confidential basidiomycete
CYP5359Z5 confidential basidiomycete
CYP5359Z6 confidential basidiomycete
CYP5360A1 confidential basidiomycete
CYP5361A1 confidential basidiomycete
CYP5362A1 confidential basidiomycete
CYP5363A1 confidential basidiomycete
CYP5364A1 confidential basidiomycete
CYP5364B1 confidential basidiomycete
CYP5364B2 confidential basidiomycete
CYP5365A1 confidential basidiomycete
CYP5366A1 confidential basidiomycete
Note the following families are unusual CYP fusion proteins.
I have assigned them a block of names to keep them together.
Right now that block is reserved from CYP6001 to CYP6009.
Currently there are 4 families.
CYP6001A1 Emericella nidulans (Aspergillus nidulans)
AY502073
fusion with diooxygenase, P450 (C-term) part may act
like a hydroperoxide isomerase
fatty acid oxygenase (ppoA) gene
see fungal pages for sequence
CYP6001A1 Aspergillus oryzae
Supercontig 6: 3114893-3118488 (-) strand
99% only 1 aa diff to CYP6001A1 Aspergillus flavus
see fungal pages for sequence
CYP6001A1 Aspergillus flavus NRRL3357
EQ963473
fusion with diooxygenase, P450 (C-term)
part may act like a hydroperoxide isomerase
fatty acid oxygenase PpoA, putative
Name revised from CYP6001A2
see fungal pages for sequence
CYP6001A1 Aspergillus clavatus NRRL 1
XM_001271947
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
fatty acid oxygenase PpoA, putative
Name revised from 6001A3
see fungal pages for sequence
CYP6001A1 Aspergillus fumigatus Af293
XP_751750.1 SAME AS EAL89712.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
fatty acid oxygenase PpoA
fatty acid oxygenase PpoA
Name revised from CYP6001A5
see fungal pages for sequence
CYP6001A1 Neosartorya fischeri NRRL 181
XM_001266940, same seq as DS027685
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
Neosartorya fischeri NRRL 181 XP_001266941.1
96% to CYP6001A1 Aspergillus fumigatus = ortholog
Name revised from 6001A4
see fungal pages for sequence
CYP6001A1 Aspergillus terreus
Supercontig 5: 1242713-1246265 (-) strand
79% to CYP6001A1 Aspergillus oryzae
see fungal pages for sequence
CYP6001A1 Aspergillus niger
Supercontig 17: 397517-401111 (+) strand
76% to CYP6001A1 Aspergillus oryzae
see fungal pages for sequence
CYP6001A2 Coccidioides immitis RS
XM_001247707.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
linoleate diol synthase
Name revised from CYP6001A6
see fungal pages for sequence
CYP6001A3 Pyrenophora tritici-repentis Pt-1C-BFP
XM_001936500.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
linoleate diol synthase
Name revised from CYP6001A7
see fungal pages for sequence
MSATEEAKAAWDSHVDTRTGIEPPKAADASEISTLRSAIGAPFR
AAAGLIGAVTAPVPDQTGDGSKIPPEEKASLYKKIEGGLRDMSHLGIENIGSLLEIQK
EKMLGSYTDDKTYLMEGLIRTAAALPDGSKTRDAVTANFLSQLWNDLQHPPQSYLGTK
YQYRSADGSNNSLVNPQVGAAGTPYARTVKPITMQTPARPDPGVIFDSIMTRKHAELH
PNRISSMLFYLASIIIHDCFRTSHEDYSISMTSSYLDLSPLYGSNQAEQDMMRTGKDG
KIKPDCFSESRLLFFPPGVGALLIMFGRFHNYTVENLAEINEQGRFTKPSAEVPKSTG
DVEVDKKTQEKYDAAWKKYDNDLFQTGRLITCGLYVNTILIDYVRTILDLNRTDSNWQ
LNPRSEVEGLPMGIGNQVSAEFNLVYRWHSTVSDRDEKWTQEMWEGIFGEDCDPKSIG
KHEFLGRLNEVYKKTDRDPSKREFAGLKRNEDGTFPDQGLVDILTSSIEDCANSFGPN
RVPSVFRAIEVLGIEQARSWNLGSLNEFRKHFKLEPHKTFEDITSDKYVQEQLKHLYD
TPDKVEIYPGMVVEDAKKPMAPGSGLCTNYTISRAVLSDAVALVRGDRFYTQDYNPRT
LTNWGYNLADSDIGIDNGCVFYKLFLRALPQHFKYNSVYAHYPLTVPSAMQIALTDLK
KDHLYDFSKPVATPHPHIVKEYKLATQIMKDQTNFKVVWGRAMEYIMGPTAADFMLAG
DGPKNTASRQMMSKALYISDWDKEVRTYYTLKMQQLLQEKAAKIADFNQVDIIRDVGN
LAHVHFCSELFMLPLKTDDRPYGIFTEAELYLIMSSVFALIFFDADPASSFPLHVKAR
KATQILGTIVEKNVAAIAKSGILSSIIQTIWPHESVLKSYGVHMIKRLLETGMEPKQL
VWGHILGTAGGMVSNQGQLFAQTLEYYILGAGQKHWPAIQALAAQDGEEAFETLMHYT
MEAGRLNGETGVIRAVAHPTPLTTADGTTTTLSPGSTVFVKLRSASHDPAVFPNPDEV
DITRPLDSYIHLGYGPHQCLGLPMTRVALTTMLKEVAKLKNLRPAKGPQGKIHKVEKR
MEKVAEEEYVYHAYLTENWDMYFPFPCALKLCWDD
CYP6001A4 Mycosphaerella graminicola
55% to CYP6001A3 Pyrenophora tritici-repentis
see fungal pages for sequence
CYP6001A5 Mycosphaerella fijiensis
JGI gene model estExt_Genewise1.C_11811
70% to CYP6001A4 Mycosphaerella graminicola
see fungal pages for sequence
CYP6001C1 Emericella nidulans, Aspergillus nidulans
AY613780.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
FATTY ACID OXYGENASE PpoC (Afu3g12120)
see fungal pages for sequence
CYP6001C2 Aspergillus fumigatus Af293
XP_754409.1 SAME as EAL92371.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
fatty acid oxygenase PpoC
95% to CYP6001C2 Neosartorya fischeri = ortholog
see fungal pages for sequence
CYP6001C2 Neosartorya fischeri
Supercontig 574: 1021375-1025419 +
82% to CYP6001C11 Aspergillus clavatus
see fungal pages for sequence
CYP6001C3 Ajellomyces capsulatus NAm1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
see fungal pages for sequence
CYP6001C4 Aspergillus fumigatus
EU020167
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
PpoC-like
Revised N-term
see fungal pages for sequence
CYP6001C4 Neosartorya fischeri
95% to CYP6001C4 Aspergillus fumigatus = ortholog
see fungal pages for sequence
CYP6001C5 Botryotinia fuckeliana B05.10
XM_001557594.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
MEQPHQGGPARRLTLGVPKKSTSGNASSNPQVFEGPDHSVKRAG
IVGTLESLGKVISTANRPLNTETGDGSYDTKQEQSGLLDDLKALRIKDLETLQMTMKQ
ELGSSNLADDKTMLMEKLIQLVANLPGTSKTRVKLTEVLVDELWGSLEHPPASMLGDK
YNYRQADGSFNNIRFPDIGKAGTAYARSVTPKIVQPNPKPDPGLIFDTIMSRENGGFK
PHPNNISSMLYYIASIIIHDCFRTSHEDFNISMTSSYLDLSPLYGSNQDEQNNMRTLK
DGELKPDCFSEKRLLGFPPGVGCILIMFNRFHNYVVKQLATINENGRFTPPKDNLPDD
KKQAAWKKYDNDLFQTGRLITCGLYINIILLDYLRTIVGLNRVNSTWTLDPRIEMERN
SKPGTEAGVGNQCAAEFNLVYRWHSCISQRDEKWSEDLYMKIFGKSYKEVTMQELLIG
LGKLEAMTPEDPLQRDFAGMKRGTDGKLNDDDLVNELTASIEDLAGSSGANNVPAVLR
AVEILGMEQARAWKCATLNEFRKHFGLIPHEKFSDINSDPAVYEKLKVLFDEPDLVEL
YAGLVCEDAKKPMDPGVGIGPTYTISRSILSDAVTLVRGDRFYTTDYHPANLTNWGVT
EVKYDLNVNQGCVFYKLFIRAFPNHFSYNSIYAHYPLTIPSENKKIMEKLGRADDYSW
DKPVKVPERKNIVTFDGVKSVLTNAEVFGVDNWRRGLAYLMGKPGANFMLAGDGDFFA
ERRNQMKECLYQDKWHESVKNYYESIVPRLLKRWSYNIGGTTNQVDVIRDIDNSAHVH
FAANVFHLPLKTEENPKGVYTEHELYMVLAVIFIVIFFGDVDPAKTFSLRAAGLPVTQ
DLGQLVEQNVNFISKTSLVSGIVDTFMEENNALKDYGVHMVRHLLKAGLGVHETVWSQ
ILPTAGAMVANQAQVFGQVLDFYLGDGKEHLPEINRLAKLNTAEADDILLHYLLEGIR
MYGTFGAYRTCHQNITINDGSRKVECKPGDSVFVSFVSLAQDPKIYPDPKTVRLDRPV
DSYLVYGVGSHACLGGEASRVALTAMLKCIGRLDNLRRASGPQGEMKKVPREGGFYVY
MDKMMGSEFPFPTTMKICWDGGLNEPVPVVEKGKGKKNGA
CYP6001C6 Podospora anserina DSM 980
XM_001904176.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
see fungal pages for sequence
MSDYNGNGHKASNGTGVTALNGSSSSHGSSSAHQSREGMELVAS
QAKPRPTPLDLKPTGANRAGVANAFERYGQVMQSSVAPLPNQHGADTFSRSKKWGKLR
DDVKQLRLADYKTLLGVVKAKVKGEKIKDDKTMAMEKVIQLVSNLPSNSKTRTELTNS
FLSELWYTLEHPPSMYVGEKFQYRQADGSYNNVMFPQLGAAGTSYSRSVAANVVRQGA
LPDPNLIFESVMKRTEYTEHPNNVSSILWYWASIIIHDLFWTDYRDMSKSKTSSYLDL
SPLYGSNQDMQDTIRTFKDGKIKPDCFADKRLLGMPPGVGVFLIMFNRVHNHVAENLA
RINEDGRFSPPSPNLEGEKKEAAWKKYDNDLFQHARLITSGLYINITLLDYVRNIVNL
NRVDTTWTLDPRVETGINVDTKEGAERGTGNVCSAEFNLCYRWHSCISAKDDKWIQDF
YYDLFKKPGKDLSIHELIMGFGKFEGMIPDDPAERPFNKFQRGPDGKFNDDDLVNCIS
DAIEDPAGSFGARNVPESMRAVEILGIIQGRRWNVAGLNEFRKHFGLKPYEKFEDINS
DPGVAESLRRLYDHPDFVELYPGLVAEERKEPMVPGVGIAPTYTISRVVLSDAVCLVR
GDRHYTIDYTPRNLTNWGFNEVQYDLNINHGCVFYKLFLRAFPNHFKYNSVYAHYPMV
TPSENSKILKDLKRAHLFDFSRPGRIATPTEVTSYDGAQRIFAAEDKFKSTWNAGVAG
IRAKASPELSGDAAVHDRHRTTASRSLFTPELGTQIKAFYESLTDKLLTTKSYTLVPG
SKFADLVRDIANIVPTHFAASVFGLPLTTKENRKGIYTEHELYAVLQIIASALFVDSE
PVKLFPVVEAAKTVAGQLGTLVDKTVKSPKAAKNSVLNTFGVNFIKELKKAGLATHDI
TWNHVLPTAAALASSQGELFTQAVDYYLSPEGAAHVADITAIASQPSSSQNDALLLGY
VLEGIRLSGSARSHFEATTAGTVTASNGTELQIQPGSKVTINSSTASRDAAYFPEPET
VNPRRPLDKYIHFDAGPHAFLGKEISQIALTEMFRALFKRKNVRRAPGPQGELKKVPR
ADGNGVDYLREDWGALTPFPVTMKVMWDEV
CYP6001C7 Neurospora crassa OR74A
XM_954756.2
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
see fungal pages for sequence
CYP6001C7 Neurospora discreta
JGI gene model estExt_Genewise1.C_90088
92% to CYP6001C7 N. crassa
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
See fungal pages for seq
CYP6001C8 Nectria haematococca
JGI gene model e_gw1.11.503.1 [Necha1:49009]
Necha1/scaffold_11:165096-168594
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
Note the YRKAE seq is near the end of the PpoC like gene in A. nidulans
The P450 motif is later, like it is added on at the end.
CYP6001C8 Fusarium oxysporum
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
ortholog to CYP6001C8 Nectria haematococca
name revised from CYP6001C9
See fungal pages for seq
CYP6001C8 Fusarium verticillioides
98% to CYP6001C8 Fusarium oxysporum = ortholog
Name revised from CYP6001C9
See fungal pages for seq
CYP6001C10 Fusarium graminearum
AACM01000456 FGcontig1.456_scaffold8
88% to CYP6001C8 Fusarium verticillioides
very poor match 39% to FG02668.1
linoleate diol synthase a modified P450 fused to a dioxygenase
See fungal pages for seq
CYP6001C11 Aspergillus clavatus
81% to CYP6001C2 Aspergillus fumigatus
See fungal pages for seq
CYP6001C12 Aspergillus oryzae
Supercontig 6: 2075682-2079724 (-) strand
100% to CYP6001C Aspergillus flavus
See fungal pages for seq
CYP6001C12 Aspergillus flavus
69% to CYP6001C1 Aspergillus nidulans
See fungal pages for seq
CYP6001C13 Aspergillus oryzae
Supercontig 26: 1555206-1559023 (-) strand
See fungal pages for seq
CYP6001C13 Aspergillus flavus
74% to CYP6001C4 Neosartorya fischeri
99% to CYP6001C13 Aspergillus oryzae
See fungal pages for seq
CYP6001C14 Aspergillus terreus
64% to CYP6001C13 Aspergillus oryzae
See fungal pages for seq
CYP6001C15 Aspergillus niger CBS 513.88
72% to CYP6001C12 Aspergillus oryzae
See fungal pages for seq
CYP6001C16 Aspergillus terreus
78% to CYP6001C12 Aspergillus oryzae
See fungal pages for seq
CYP6002A1 Emericella nidulans (Aspergillus nidulans)
AY940146
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
PpoB
See fungal pages for seq
CYP6002A2 Fusarium oxysporum
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
See fungal pages for seq
CYP6002A3 Aspergillus clavatus
42% to CYP6001A2 (over full length)
up to 71% to 6002A1 in parts
See fungal pages for seq
CYP6002A4 Neosartorya fischeri
71% to CYP6002A3 Aspergillus clavatus
Note: this seq does not have an ortholog in A. fumigatus
See fungal pages for seq
CYP6002A5 Aspergillus terreus
65% to CYP6002A4 Neosartorya fischeri
See fungal pages for seq
CYP6002A6 Mycosphaerella graminicola
52% to CYP6002A4 Neosartorya fischeri
See fungal pages for seq
CYP6003A1 Gibberella zeae (Fusqarium graminearum)
XP_382844
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
87% to CYP6003A2 Fusarium verticillioides
See fungal pages for seq
CYP6003A1 Fusarium oxysporum
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
Ortholog to CYP6003A1 Gibberella zeae
Name revised from CYP6003A2
See fungal pages for seq
CYP6003A1 Fusarium verticillioides
98% to CYP6003A2 Fusarium oxysporum ortholog
Name revised from CYP6003A2
See fungal pages for seq
CYP6003A1 Nectria haematococca (Fusarium solani f. batatas)
JGI gene model estExt_Genewise1Plus.C_sca_20_chr6_4_01131
84% to CYP6003A2 Fusarium oxysporum = ortholog
name revised from CYP6003A2
See fungal pages for seq
CYP6003B1 Aspergillus oryzae RIB40
XM_001727759.1 revised 3/17/2009
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
See fungal pages for seq
CYP6003B1 Aspergillus flavus
99% to CYP6003B1 Aspergillus oryzae
See fungal pages for seq
CYP6003B2 Aspergillus terreus NIH2624
XM_001211214.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
See fungal pages for seq
CYP6003B3 Aspergillus niger CBS 513.88
XM_001395183.1
fusion with diooxygenase, P450 (C-term) part
may act like a hydroperoxide isomerase
See fungal pages for seq
CYP6003B4 Mycosphaerella graminicola MgPOSS40860
51% to CYP6003B2 Aspergillus terreus
See fungal pages for seq
CYP6004A1 Mycosphaerella graminicola
only 33% to CYP6001C16 Aspergillus terreus, no heme signature
See fungal pages for seq
CYP6004A2 Mycosphaerella fijiensis
JGI gene model e_gw1.1.1178.1
65% to CYP6004A1
32% to CYP6001A1
See fungal pages for seq
CYP6005A1 confidential basidiomycete
CYP6005B1 confidential basidiomycete
Unnamed pieces Nov. 1 2006
CYPXXXX Euglena gracilis (Euglenozoa)
GENEMBL EC678170.1, EC682131.1, EC679294.1, EC677985.1 ESTs
N-term
MALGRGLLVRLLPAGLVVLASAGWLFHRRQKAKARTAPPRAPYTPWQLLQLFQ
GPCWPETLLLLCREMATPVFRVRRLPWGDIYVADDWQLAQRIFHDKETDKPKGIRVINAI
TGGRPSLFTALTRSAEWQAHRRHVAPA
FRTKVLGAQTPALRAKLGDFYAILAEHAARGTPVDMDDLLMYLTLDFISLSAFDYDLCAL
REQSSEGRRFLQSTSFVLAEMTKRVFEPLRRWKFWLPEAHRLKADTQWMKELSLRILRAY
RAAHPADAIATDDRILAHLIRDSQYPDEEARAADVTMFLVAGHDTTAHTLAWTLYELSQ
CYPxxxx Diplonema papillatum (Euglenozoa)
GenEMBL EC844159
39% to 704B2 C-term, possible 86 clan member
DGGRIREQTVTNDQTLTGLFLQHAQDDPELVGKGKVGLKTFVRDMILNFVIVGRDTTGAA
LTSCVEFLVEPENAHWQAALHKEALACFGDNAVSEALTFDDVEGKSPVSEAVFMEALRLH
PSVPGNKKMCDVDTTFPSGLAVPKGVFVGWITYAMNRNTRVWGPDAAAFQPQRWIKADGA
ITTEFDDYMYPTFNAGPRLCLGKNMAILE
Monosiga brevicola (choanoflagellate, single celled siste group to all animals)
From JGI site estExt_fgenesh1_pg.C_170105 [Monbr1:37875]
Note: the JGI prediction has another protein fused upstream to the P450 part
36% to 4A7 rabbit
MLEYATTAIWTALAIILVRWIVKTVISIRAIEKLPGPKFKFPLGTLYAHPTPVEHVKLIKR
LSAENPTSGFRFWLGPVQAVCVLNHPQAVRAILEDEPPKAPMLYRYIQPWLGEHSLLTLEGERWKNMRRL
LTPAFHLHILHHYAPVIVDASSIIIEKFLNHAKTKPEEDYDVFSDYALLTLDVICRAAFSHEGDPQRNPE
DKYAVSIGQIAESIIARAINPKMMFDGVYYRSKEGKEFQELLDYVHDHADNLIDKRAKEIEGLTLDDIGR
TRPGGRTLLDFLDILLTTQDENGQRLSKEAIRHQCDTFLFAGHDTTSSCLSWLSYLLSVNPEAQEKCRKE
IFDAFGDEAPTYEDVQKKIPYLTCCIKEALRMYPPIPGVARKLTKPVNVGSTVLQPGTTAAVGILALHYN
PTLWEEPTKFKPERFETGVKHDSYSFLPFSIGRRNCIGQNLALNEIRLAMCQILRKVVILPSAEKDYEPQ
PMSQIVLRSENGVRMRFKAYEE*
CYP like 4V
Monosiga brevicola (choanoflagellate, single celled siste group to all animals)
From JGI estExt_fgenesh2_pg.C_170049 [Monbr1:33214]
MAAAAANQAMDLAHQGLDWAFHRVVLQAATILPPWLLRHVPANWQALTPAKLAVVTPAAFIVARIVMHQL
HQLRIKFALRNVQRAPQWLPIVGHTWALLIGTPWDVFHSWFETTGADLLKANVMGENSLLVYKPRHLRQI
MNSKLHNYPKDVDFAFKTFMDILGSGLVSSNGALWKKQRTLLSHALRIDILEETMPVAKRAIDRLSEKLE
AIRGTGEYIEIAEEFRVLTLQVIGELILSLSPEESSRVFPDLYLPIMEEANRRVWEPYRAYIPTPGWFHY
NRTLHELNNYLCNLIRKRWADRQAAVAAGTNEDDKDILEVIMADIDPATWGEGTVLQLRDEIKTFIMAGH
ETSAAMMTWACYELHRHPEVREKFIQEAQAVFGTGIAADAEGADKFTKTPLPANEQLKGLQYTMNVLKET
LRFYSLVPVVARVTVEDDVLDGHVVPAGTRILISLRSAHDNPETWKDPMTYRPERFDEPFDLYAFMPFIQ
GPRNCLGQHLALLEARIVMALLMLRFKLTPRDESCGERHPSIVPVCPKNGMWVRVD*
Monosiga brevicola (choanoflagellate, single celled sister group to all animals)
From JGI estExt_fgenesh1_pg.C_280109 [Monbr1:38613]
MWMAVALVVVAGVVLVPLLLLYPFLPDLRQWHRVRQVYNARFGAFVLWFAYEPNVVLTRPEDIKQLLTDN
DLNYTRDNSSFALFNRFIGQSIINANGEEWRRQHRILYKAFSPDKLVGFRSTFANRGERLAHSLLELSQA
EGSVKLGHWLGKMTLSVIIETAFGNTLRPDEQDLMAQEFIYMTNEFTNFAHQIPVLRHVLTDTQRLETGF
ERLYGLVDQAVARRRSGEQDDGQIKLIDLILEANGEEDDRSRLDDAAMRDNLLLLLAAGTETTATTLGWL
LYELAVNPKVFRPARFAPGGEVEQNPFQYFPFGKGRRYCLGKYFAIAELQVVVSHLLRRLDMEYLGDRAT
MRVVYKPPVLHASDDLPMRFFARRTSRRGSKLVEAV*
Unidentified fragments from birds, fish and mammals
rat
PIR S39762 (12 amino acids)
Ohishi, N., Imaoka, S., Suzuki, T. and Funae, Y.
Characterization of two P-450 isozymes placed in the rat
CYP2D subfamily.
Biochim. Biophys. Acta 1158, 227-236 (1993)
rat
PIR S39763 (10 amino acids)
Ohishi, N., Imaoka, S., Suzuki, T. and Funae, Y.
Characterization of two P-450 isozymes placed in the rat
CYP2D subfamily.
Biochim. Biophys. Acta 1158, 227-236 (1993)
rat
PIR A61597 (8 amino acids)
Shimeno, H., Toda, A., Ogata, S. and Nagamatsu, A.
Purification and aminopyrine monooxygenase activity of liver
microsomal cytochrome P-450 from alloxan-induced diabetic rats.
Drug Metab. Dispos. 19, 291-297 (1991)
rat
PIR B61597 (14 amino acids)
Shimeno, H., Toda, A., Ogata, S. and Nagamatsu, A.
Purification and aminopyrine monooxygenase activity of liver
microsomal cytochrome P-450 from alloxan-induced diabetic rats.
Drug Metab. Dispos. 19, 291-297 (1991)
rat
PIR E41425 (16 amino acids)
Imaoka, S., Kamataki, T. and Funae, Y.
Purification and characterization of six cytochromes P-450
from hepatic microsomes of immature female rats.
J. Biochem. 102, 843-851 (1987)
rat
PIR C60822 (20 amino acids)
Amelizad, Z., Narbonne, J.F., Wolf, C.R., Robertson, L.W. and
Oesch, F.
Effect of nutritional imbalances on cytochrome P-450 isozymes
in rat liver.
Biochem. Pharmacol. 37, 3245-3249 (1988)
rabbit
PIR A45103 (15 amino acids)
Ishida, H., Noshiro, M., Okuda, K. and Coon, M.J.
Purification and characterization of 7
alpha-hydroxy-4-cholesten-3-one 12 alpha-hydroxylase.
J. Biol. Chem. 267, 21319-21323 (1992)
This is a P450 involved in bile acid synthesis and it may be a new
mammalian family.
pig
PIR S15850 (9 amino acids)
Bergman, T. and Postlind, H.
Characterization of mitochondrial cytochromes P-450 from pig
kidney and liver catalysing 26-hydroxylation of
25-hydroxyvitamin D(3) and C(27) steroids.
Biochem. J. 276, 427-432 (1991)
pig
PIR S17048 (10 amino acids)
Sono, H., Sonoda, Y. and Sato, Y.
Purification and characterization of cytochrome P-450(14DM)
(lanosterol 14-alpha-demethylase) from pig liver
microsomes.
Biochim. Biophys. Acta 1078, 388-394 (1991)
May be N-terminal of pig CYP51 see rat CYP51 (missing N-terminal)
Chicken
PIR S29135 (28 amino acids) PIR S29136 (28 amino acids)
PIR S29137 (16 amnio acids) PIR S29138 (30 amino acids)
Gupta, R.P., Lapadula, D.M. and Abou-Donia, M.B.
Purification and characterization of cytochrome P450 isozymes
from beta-naphthoflavone-induced adult hen liver.
Arch. Biochem. Biophys. 282, 170-182 (1990)
chicken
PIR A44107 (25 amino acids)
Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
Beta-naphthoflavone induction of a cytochrome P-450
arachidonic acid epoxygenase in chick embryo liver distinct
from the aryl hydrocarbon hydroxylase and from
phenobarbital-induced arachidonate epoxygenase.
J. Biol. Chem. 267, 19503-19512 (1992)
PIR A61056 (19 amino acids)
Gupta, R.P., Lapadula, D.M. and Abou-Donia, M.B.
Purification and characterization of cytochrome P-450
isozymes from phenobarbital-induced adult hen liver.
Comp. Biochem. Physiol. 96C, 163-176 (1990)
chicken
PIR B61056 (19 amino acids)
Gupta, R.P., Lapadula, D.M. and Abou-Donia, M.B.
Purification and characterization of cytochrome P-450
isozymes from phenobarbital-induced adult hen liver.
Comp. Biochem. Physiol. 96C, 163-176 (1990)
chicken
PIR B44107 (26 amino acids)
Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
Beta-naphthoflavone induction of a cytochrome P-450
arachidonic acid epoxygenase in chick embryo liver distinct
from the aryl hydrocarbon hydroxylase and from
phenobarbital-induced arachidonate epoxygenase.
J. Biol. Chem. 267, 19503-19512 (1992)
chicken
PIR C44107 (26 amino acids)
Nakai, K., Ward, A.M., Gannon, M. and Rifkind, A.B.
Beta-naphthoflavone induction of a cytochrome P-450
arachidonic acid epoxygenase in chick embryo liver distinct
from the aryl hydrocarbon hydroxylase and from
phenobarbital-induced arachidonate epoxygenase.
J. Biol. Chem. 267, 19503-19512 (1992)
Oncorhynchus mykiss (trout)
GenEMBL T23107 (310bp)
Gong,Z.
unpublished (1994)
Note: 45.1% identical to 52A10, with similarity to other 52 family
Members