Alignments of various collections of P450s
protein sequences. Currently, this includes 429 sequences (31 more than in Sept.)
Some sequence fragments have been eliminated because complete sequences replaced
them. Several ESTs were combined into a single sequence. My current confidential
alignment has 504 sequences, but there are more not yet entered. In addition to the
alignments, the latest bibliographic information on the sequences is provided as well as
accession numbers from GenBank, SwissProt and PIR (Protein Information Resource).
These files have been created and are being maintained by David Nelson
at The University of Tennessee, Memphis, College of Medicine,
Dept. of Biochemistry. Comments can be made to Dnelson@utmem1.utmem.edu.
These alignments have a fixed length. If a sequence has an insertion that will not fit
in the alignment as it is here, the insertion has been left out. This is most common
just before the I-helix region.
An alignment of 192 P450 sequences,(160k)
This file has the first 192 sequences of the 429 sequence alignment.
This includes the CYP2 family, CYP1, CYP17, CYP21 and plant families
71-80, 82, 83, 88, 90 and 92. There are 90 members in family 2 and 62 plant
sequences (some are PCR fragments).Last updated April 19, 1996.
An alignment of 237 more P450 sequences,(186k)
This file has sequences from 193-429. This file includes insect and bacterial
sequences. The families in this section of the alignment are CYP families 3, 4,
5, 6, 7, 8, 9, 10, 11, 13, 14, 16, 19, 22, 23, 24, 25, 27, 51, 52, 53, 55,
56, 57, 58, 59, 60, 61, 62, 72, 74, 101-119. Last updated April 19, 1996.