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Phylogentic trees of selected P450 groups

What’s New Jan. 2, 2002

There is a tree with 60 human 47 Fugu and 8 other fish sequences.

What’s New Jan. 19, 2000

I have posted a 4 family tree with 89 sequences, including the new Drosophila sequences in the 4 family and in the 18 clan. A second tree covering the remaining sequences including the 6, 9, 12 and 28 families is also here.

This page holds phylogenetic trees of P450s from different groups of sequences.

This image is a phylogenetic tree of 43 sequences.
They are single members of subfamilies from the top half of the P450 tree.
The sequences are from top to bottom: 2C9, 2H1,2E1,2F1,2G1rat,2A6,2Q1
2B6,2M1,2N1,2P1,2Jer1,2D6,2K1,2L1,18,1A1trout,1A1human1,1A2chick,
1B1human,17,21,71A1,71C1,71B1,83,84,76A1,76B1,75A1,80,
82,73A1,81A2,78A1,79,77A2,89,85,90,87,88 and 86A1
Note: The last five sequences naturally fall in the lowerhalf of the tree.
They are included here, because they are plant sequences. See the single
family member tree for a more accurate placement of these sequences.

This image is a phylogenetic tree of 57 sequences.
They are single members of subfamilies from the bottom half of the P450 tree.
The sequences are from top to bottom: 13,3A3,4H1,5A1,9C1,15,9B1,9A1,6A1,
6C1,6B1,6D1,4A11,4B1,4F2,4L1,4K1,4D1,4E1,4C1,4M1,4J1,4G1,4P1,102,
118,110,72A1,24,4N1,27,10,11A1,11B1,12,52A1,52D1,52B1,52E1,52C1,
14A1,53,57A1,60A1,60B1,62,58,56,59,19,61,51,8,7A,7B,54,74
Note: This tree does not include the 85, 86, 87, 88, and 90 plant families that were
included in the upper half of the tree.See the single family member tree for a more
accurate placement of these sequences.

This image is a phylogenetic tree of 55 sequences.
They represent single members of P450 families, not including the bacterial
cam-like sequences.
The sequences are from top to bottom: 2C9,18,1A1,17,21,14,71A1,84,83,75A1,
76A2,80,82,73A1,81A1,78A1,79,77A2,89,13,3A3,5A1,6A1,15,9A1,
4A11,102,118,52A1,110,72A1,56,24,27,10,11A1,12,85,90,87,88,53,57A1,
60A1,62,58,59,86A1,19,61,51,54,7A,8,74.

This image is a phylogenetic tree of 30 bacterial cam-like
P450s. The CYP102, CYP110 and CYP118 (Eukaryote-like) are not included.
The sequences are from top top bottom: 105A1,105D,105B,105A2,55A1,55A2,
55A3,105C,105E,107G,107D,107E,107F,107A,107B,107C,112,114,113A,
113B,106A1,106A2,109,111,108,101,116,103,104,117.