This section houses alignments of all publicly available Cytochrome P450 protein sequences. Currently, this includes 429 sequences (31 more than in Sept.) Some sequence fragments have been eliminated because complete sequences replaced them. Several ESTs were combined into a single sequence. My current confidential alignment has 504 sequences, but there are more not yet entered. In addition to the alignments, the latest bibliographic information on the sequences is provided as well as accession numbers from GenBank, SwissProt and PIR (Protein Information Resource). These files have been created and are being maintained by David Nelson at The University of Tennessee, Memphis, College of Medicine, Dept. of Biochemistry. Comments can be made to Dnelson@utmem1.uthsc.edu. These alignments have a fixed length. If a sequence has an insertion that will not fit in the alignment as it is here, the insertion has been left out. This is most common just before the I-helix region.
This file has the first 192 sequences of the 429 sequence alignment.
This includes the CYP2 family, CYP1, CYP17, CYP21 and plant families
71-80, 82, 83, 88, 90 and 92. There are 90 members in family 2 and 62 plant
sequences (some are PCR fragments).Last updated April 19, 1996.
An alignment of 237 more P450 sequences,(186k)
This file has sequences from 193-429. This file includes insect and bacterial
sequences. The families in this section of the alignment are CYP families 3, 4,
5, 6, 7, 8, 9, 10, 11, 13, 14, 16, 19, 22, 23, 24, 25, 27, 51, 52, 53, 55,
56, 57, 58, 59, 60, 61, 62, 72, 74, 101-119. Last updated April 19, 1996.
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