A new human CYP family CYP39A is now represented by a complete sequence. This was assembled over several days by using every trick in the book to find all the pieces. I suspect this will be an important P450, with an ancient history, probably acting on sterols. The gene is also found as ESTs in… Read More
A new human P450 has been found named CYP26B1 that is 44% identical to 26A1 from mouse and humans. The sequence was found in genomic DNA AC007002. The reference is in press. Nelson, D.R. (1999) A second CYP26 P450 in humans and zebrafish: CYP26B1. Archives of Biochemistry and Biophysics in press.
The server has been upgraded from an ancient Quadra 650 circa 1994 to a PowerMac 7100. This is not new, but it is a step up from the old Quadra. You should notice some improvements in speed. If you have any trouble accessing any part of this site let me know so I can check… Read More
A new tree of the CYP81 family is posted under the trees button. This does not contain all CYP81 sequences, but it has all the subfamilies represented.
Soybean has a large number (86) of P450 containing ESTs. I have collected these, and incorporated them in a list with 22 full length soybean P450s. This is a new format that uses the Entrez Nucleotide query output for each entry. These have been modified to include my own annotation and translations to make them… Read More
7938 new Arabidopsis ESTs were deposited in Genbank on Sept. 8. I have looked at them by Blast searches over the weekend and I found 57 that contain P450 sequences. 47 of these are close or exact matches to known P450s from Arabidopsis (96% or better identity). Nine ESTs are new sequences that range from… Read More
On Sept. 8, 1999 Genome Systems, Inc., a wholly owned subsidiary of Incyte Pharmaceuticals, Inc. deposited 7938 Arabidopsis mRNA sequences into Genbank. These ESTs run from AI992384-AI999813 and from AW004082-AW004589. This is about 4 – 4.5Mb of sequence. Currently, these cannot be searched for P450 genes by BLAST. It may take a day to update… Read More
The Cytochrome P450 homepage has a new look. A table has replaced the 15 gif images that used to serve as buttons. This should shorten loading time and improve the feel of the page. It will also allow addition of new buttons for different species as time goes on. (There are many soybean ESTs, and… Read More
A tomato EST project has generated more than 26,000 ESTs, with 8616 deposited in March, 11789 in June, and 5394 in July 1999. These have now been searched for P450 containing sequences. There are 235 P450 coding tomato ESTs. These sort into 58 contigs, that include 5 complete genes (CYP51, 73A24, 76A6, 88B1 and 707A4)… Read More
A new 68 sequence tree with the CYP4 family is given. This has 63 4 Family sequences, and 5 additional sequences. The 48 family and the CYP4P subfamily are at a boundary between the insect cluster and other animal CYP4 members. On earlier versions of this tree they fell outside the 4 cluster. Here they… Read More
