14 complete or almost complete P450s have been assembled from the genomic and EST sequence data at Jena, Baylor College of Medicine, Genbank and the Japanese Project. Many of the dicty P450s have a short N-terminal exon that is still unidentified. There are now 439 sequence fragments that have been assembled into 64 contigs. In… Read More
The current count of human P450s stands at 53 genes plus one candidate 2A gene that is partial. There are 22 pseudogenes. I have dropped some of the 2D pseudogenes from this count since there appears to be only 1 2D6 gene and 2 pseudogenes. The others are various alleles of these three formed by… Read More
A new human P450 has been found on AC010383.2 that looks like a fungal P450 from Agaricus bisporus (mushroom). I wonder if it might be a fungal contamination of the library? I have pieced part of it together, but it is still not complete. The two short introns are not like a human gene. Contig… Read More
A consideration of the effect of genome duplications on P450 evolution in vertebrates is given Where did all the P450s go?