The C. elegans genome is now nearing completion. I have just done a comprehensive search of C. elegans for P450s and named all the new sequences. There are 80 genes for P450s in C. elegans. Some of them are in large clusters with 10-13 genes, some of which are probably in operons. A small number… Read More
I have searched for new cytochrome P450s in Arabidopsis and find 37 full length P450s that are new or that complete fragments from ESTs. There are also 38 new ESTs for Arabidopsis P450s. New Arabidopsis sequences There is a new file with the protein sequences of public Arabidopsis P450s FASTA Arabidopsis sequences
The crystal structure of CYP55A1 has appeared in Nature Structural Biology volume 4, number 10, October 1997 pp. 827-832. This enzyme is a nitric oxide reductase. The source is fungal (Fusarium oxysporum), though the protein is soluble and falls in phylogenetic trees in the 105 family. This probably represents a lateral gene transfer from a… Read More
On naming P450s, problems and approaches The four tables of the P450 database (plants, animals, bacteria and lower eukaryotes) are under construction. It may take a while to get the data entered that will make these tables useful. If you have additional suggestions, let me know.
The Arabidopsis data listed for Arabidopsis families and Arabidopsis ESTs has been updated. .
I have revised the genes per species data listed here
Francis Durst has asked me to post an announcement and web link for the IVth International Symposium on Cytochrome P450 Biodiversity and Biotechnology to be held in Strasbourg, France July 12-17 1998. I wouldn’t want to miss this one. Jump to Strasbourg
The new C. elegans sequences have been assigned names with 17 members in the CYP33 family and 9 members in the CYP35 family.
I received permission to put the C. elegans translations on my webpage. To see the sequences that are presented in the same order as the list below click here .
*** Note The CYP1B1 gene has been linked to primary congenital glaucoma**** See April 97 Human Molecular Genetics