I have posted a sequence alignment of all 57 human P450 proteins. This includes 53 probable functional genes and 4 pseudogenes (2G1P, 2G2P, 2T2P and 2T3P) This alignment is assembled from previous alignments I had with addition of new sequences. The alignment could be improved, so watch the version date. I am preparing a second… Read More
The Pseudomonas aeruginosa genome is complete but not published. The sequence is available on a server and it contains three P450 genes. The sequences of these have been posted in the file of bacterial P450 sequences as CYP107S1, CYP168A1 and CYP169A1.
48 New bacterial P450s have been named in an attempt to catch up on the long neglected bacterial section of the nomenclature. I have posted a fasta file of the public bacterial sequences under the bacteria button on the homepage. This is not all the bacterial P450s but it is a good start.
I have posted the talk I gave at Stresa Italy at the MDO2000 meeting on July 10. This talk includes the slides that I used, and a few comments on things that have changed since July 10. GO TO TALK
14 complete or almost complete P450s have been assembled from the genomic and EST sequence data at Jena, Baylor College of Medicine, Genbank and the Japanese Project. Many of the dicty P450s have a short N-terminal exon that is still unidentified. There are now 439 sequence fragments that have been assembled into 64 contigs. In… Read More
The current count of human P450s stands at 53 genes plus one candidate 2A gene that is partial. There are 22 pseudogenes. I have dropped some of the 2D pseudogenes from this count since there appears to be only 1 2D6 gene and 2 pseudogenes. The others are various alleles of these three formed by… Read More
A new human P450 has been found on AC010383.2 that looks like a fungal P450 from Agaricus bisporus (mushroom). I wonder if it might be a fungal contamination of the library? I have pieced part of it together, but it is still not complete. The two short introns are not like a human gene. Contig… Read More
A consideration of the effect of genome duplications on P450 evolution in vertebrates is given Where did all the P450s go?
Searches for P450s in the human genomic DNA sequences being deposited in Genbank have identified several new human P450s. These include the five shown below and others. One is 43% identical to CYP27A1 and has been named CYP27C1. See the human section of the homepage for detailed PDF tables sorted by chromosome, CYP name or… Read More
The Plant P450 Database has exceeded 500 sequence entries. The database has been updated to include the latest information on which sequences are still confidential and which have become public. Many new sequences have been added since the last revision in August 99. Please note that slightly more than half of these sequences are from… Read More