Click here!Click here!These pages change frequently. Oct. 21, 2014
The sequence guru at work
David Nelson dnelson@uthsc.edu
My phone is (901) 448-8303 My FAX is (901) 448-7360
will be held in Woods Hole, Massachusetts, USA Oct. 3-7, 2010. A Link to the website
will be held in Nice, France June 8-12, 2008. A Link to the website
will be held July 6 to 10, 2008, at Saratoga Springs, NY, USA. A Link to the website
was held in Swansea, Wales UK July 23-27 2006. A Link to the website
Will be held 3-7 September 2006, Budapest Hungary. A Link to the website
I have counted the number of named cytochrome P450s as of May 28, 2006.
There are Animals = 2255, Plants = 1918, Bacteria = 629, Fungi = 1001,
Lower eukaryotes = 205 sequences named. That is a total of 6008 different sequences.
for a list of these sequences see P450 Stats Page
A BLAST server has been set up on a RedHat Linux machine to allow blast
searching of selected P450 sets. There are 27 P450 sets to choose from. Only BLASTP or BLASTX work since this is a protein database. The server address is
http://blast.uthsc.edu/ GO THERE NOW
THE CRYSTAL STRUCTURE OF CYP3A4, THE MOST PROLIFIC HUMAN DRUG METABOLISING
P450, HAS BEEN SOLVED BY ASTEX.
SEE THE
ASTEX PRESS RELEASE
A table of P450 accession numbers, (60k)
This is a list of all known cytochrome P450 accession numbers from PIR 44 (4/12/95)
SwissProt 31 (3/20/95) and GenBank 89 (6/9/95).
.
The following list is a
familycount, (2k) This is a brief listing of the breakdownof the 477 sequences in the alignment, how many families, subfamilies, how many
plant familes, mammalian families etc.
.
The number of genes in a given species is listed
here last modified Dec. 3, 1998.
The distribution of P450s in each family between major biological classes (mammals,
fish, birds ) is given
here (3k).
A midwest P450 Symposium server
.
.
Kirill Degtiarenko has also set up a cytochrome P450 WWW server in Trieste, Italy.
This server has features not included here, such as hyperlinks to the database
entries for Genbank and SwissProt accession numbers. He has some bibliographic
information that is different from the file maintained here. Some additional types of
sequences are also included, such as NADPH cytochrome P450 reductases and
NO synthases. To connect to Kirill's server click
here.The larger files of the alignments, the bibliography and the accession number table
will be posted on Kirill Degtiarenko's server to help those having difficulty in down-
loading these files from the UK and Europe. I can see from the usage log that many
of you have not been able to get these larger files intact.
.
.
MIPS (Martinsreid Institute for Protein Sequences) has a server that has sorted families
and superfamilies of proteins. These families are listed with their member's PIR
accession numbers, and alignments made by pileup can be obtained for the families.
The superfamily number for P450s is 0027.0 and this can be connected directly by
clicking
here.The accession number table in my server has all the PIR accession numbers in the
MIPS server, but they are hyperlinked there, so you can get the sequence entry
directly. The URL for the more general section of this server is
http://www.mips.biochem.mpg.de/www/programs/classification.html
to go there now click
here..
For an equivalency table of the MIPS family numbers and the P450 nomenclature click
here.
For an obituary of Ryo Sato by Ron Estabrook click here
.